PharMolix/UniProtQA huggingface dataset:
Protein: MED3_ASHGO
Sequence: MGSNIDGILRENLTLEELQEWLTSSEGNKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQLSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSETSERKFYPKETLGTAVEPVRPLASPSYRRPSNRSSADTPSSNAPTPSAAVVSGAALVAPQVKHQRRPRTNTAKRQPSVSASVVPSANSSGPATIPGATPLMLSGMSPLNMVASPLNGISPSRKPAQPHHQTTPSAALGMQPMQQKQMSIQAKATPSKSGTISSANLTPQSILNMSAFENSAGGVPNSAVPLNQNNNAIMGFPTDIDNIDLNALELGSLNMDLLG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 3, Mediator complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABA2_BOTFB
Sequence: MLLSIKDLSEKYIMLLDVKDLSTLKTTVAVLVTVALIAQVLWKIFFHPLSAFPGPWFNRISEIPGSWVIATGKQHSYYRKLHEKYGPVVRVAPNELSFIGDRAWDDIYGVQKKGPNFEKSPIFIGAVSPLDGQTGISLAPNEAHTRQRRALAHVFSNTALLQQEEIMRSHVDKLVGQLKKTIAENRPINFSNWYTYTTFDMMGDLCFAEPFGCLDQGGATEWSTSVINVFKSAAWDQSIRRVAGVNTWLQKLMVKLLIPSKAANWRKVHFQNSREKTLRRLADGNREHKDFIYHILKNKEAKNSLSETEIILNMVLLISAGTETTASLLTGWTYFICTHPEVYKRLTDEIRGRFNSEQDITWETVKDLPYLHATLSEALRLYSPAPANQQRIVPPGGSVIDGHFVPGKTTVAVAPWAAINSSLNFKDPQKFIPERWLGDERFVNDKLNASQPFSLGPRGCIGKNLSFFEMRLITSRLLWNFDVSLVTTGEHGETNKLWDMDGAGKYMKVYQTWNKPDMWVMLKEVPR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses (PubMed:15240257, PubMed:16820452).  The first step of the pathway catalyzes the reaction from farnesyl diphosphate to alpha-ionylideneethane performed by the alpha-ionylideneethane synthase aba3 via a three-step reaction mechanism involving 2 neutral intermediates, beta-farnesene and allofarnesene (PubMed:30226766).  The cytochrome P450 monooxygenase aba1 might then be involved in the conversion of alpha-ionylideneethane to alpha-ionylideneacetic acid (Probable).  Alpha-ionylideneacetic acid is further converted to abscisic acid in 2 steps involving the cytochrome P450 monooxygenase aba2 and the short-chain dehydrogenase/reductase aba4, via the intermediates 1'-deoxy-ABA or 1',4'-trans-diol-ABA, depending on the order of action of these 2 enzymes (Probable).  Aba2 is responsible for the hydroxylation of carbon atom C-1' and aba4 might be involved in the oxidation of the C-4' carbon atom (PubMed:16820452).
What are the official names of this protein?
Cytochrome P450 monooxygenase aba2, Abscisic acid biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YIDZ_ECOSE
Sequence: MKKSITTLDLNLLLCLQLLMQERSVTKAAKRMNVTPSAVSKSLAKLRAWFDDPLFVNSPLGLSPTPLMVSMEQNLAEWMQMSNLLLDKPHHQTPRGLKFELAAESPLMMIMLNALSKRIYQRYPQATIKLRNWDYDSLDAITRGEVDIGFSGRESHPRSRELLSSLPLAIDYEVLFSDVPCVWLRKDHPALHETWNLDTFLRYPHISICWEQSDTWALDNVLQELGRERTIAMSLPEFEQSLFMAAQPDNLLLATAPRYCQYYNQLHQLPLVALPLPFDESQQKKLEVPFTLLWHKRNSHNPKIVWLRETIKNLYASMA
What is the function of this protein?
Involved in anaerobic NO protection.
What are the official names of this protein?
HTH-type transcriptional regulator YidZ.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: HEMA_INBTE
Sequence: MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPNCLNCTDLDVALARPMCIGTIPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAERAPGGPYRLGTSGSCPNVTSRSGFFATMAWAVPRDNKTATNPLTVEVPYICTKGEDQITVWGFHSDNKIQMNKLYGDSNPQKFTSSANGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: AROC_ACIC5
Sequence: MLRFSTAGESHGESLIALVSGMPAGVPIDQDFVNRELWRRQQGYGRGGRMRIEQDTAHFLSGVRHGKTIGSPIAMEIENRDWKNWTEILPVETGDASKHKAVASPRPGHADLAGALKYDFAEARYVLERASARESTARVAAGAVAKSLLLELGIDVASHVVRVGNVEMERTATWAEIAALRELDEVMLGCVDAETEARMKAEVDRALLTKDTIGGVFEVVVHGAPAGIGTYANWDERLDGVLAQAVMSLQAVKAVEIGRGVTAAASMGSDVHDAIGYAAELPEGAHTRFTRERNNAGGIEGGISNGEDVVVRGYLKPISTLRQPLASVRFDTREETKAAYERSDVCVVPAAGVAAEAMVALAFGRLLLEKFGGDSLRELKRNYDGYLEQIRRF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: AIM14_PICGU
Sequence: MHNHPRHEGHLHTVNVKYGYVVFLLSIVHIVVVATVPRLRKVGSSSTRRSLPWLPQIVIWAILLAILGVWNIHEWSEHYNVSIKRFGRMAYCLLPFDILLAYKYWPLENYLQNLNLHKWMSRIIVVCSMIHGIGYFVKWFVEGTFFHHLFKIDNLLGVVVFAAAVVLLVVSVALFRRQSYRLFYVSHNITIGMFVVLILFHARPPVTLFVAICGLLLAILFFIKFQTYSATPVSLKEVPNSSLVLVSFPWPDHIATSFKPGSHVRINHSNRSWKSWVFASHPFTSATLPGTSETLDLVVKKGTFIFAKDTQYNLSSPYTSLSFDDNSISRFDQSVIICGGSGISLAIPVFKYLITKLDVTMIWCTRSKADLFVLRHYSLLDKVQVYITGNDSLSVEDESEGHGLMHETIELENLEESSKNSEATKQPEILRGRPDLNNVCASLETTPNSSCVISCGPRSLVKDCENWCRNHKIESVTEIYEM
What is the function of this protein?
Probable cell surface metalloreductase.  May be involved in iron or copper homeostasis (By similarity).
What are the official names of this protein?
Probable metalloreductase AIM14.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family. AIM14 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYH_PSEPW
Sequence: MSKSLQAIRGMNDILPEQSPLWRYFEGTVAGLLDTYGYSQIRTPIVEFTELFKRSIGEVTDIVEKEMYTFEDRNGDSLTLRPEGTAACVRAVLEHGITGNGQVQKLWYIGQMFRHERPQKGRYRQFHQIGVEVFNLDGPDIDAELIMLTWRLWGLLGIQDAVKLELNSLGTSEARARYRDALVEFLSARLEQLDEDSQRRLKSNPLRILDSKDPNTQAVLVGAPKLEDYLDEDSRVHFEGLKARLDAAGIPFVINTKLVRGLDYYSKTVFEWVTDKLGAQGTVCAGGRYDGLVEQMGGKPTTGVGFAMGIERLILLLETLGKVPASINRQIDVYLCAFGEQAELAGLRLSESLRDRLPGLRLAVNAGGGSFKSQFKKADKSGALFALILGDDELAKQEIGLKPLRGQGEQQNIAWDALAEHLETAIAQA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_AGRFC
Sequence: MSLTRKPLASHHRIVIKIGSALLVDRKSGLKKDWLDAICEDIAALKKNGADVQVVSSGAIALGRTVLGLPSGALKLEESQAAAAVGQIALARAWSESLSRHEIVAGQILLTLSDTEERRRYLNARATINQLLKIGAIPIINENDTVATTEIRYGDNDRLAARVATMTGADLLVLLSDIDGLYTAPPHLDPDAKFLETIADITPEIEAMAGGAASELSRGGMRTKIDAGKIATAAGCGMIIASGKTLNPLKAIENGARSSWFAPSGTPVTARKTWIAGQLQPAGEIHVDAGAEKALYAGKSLLPAGVRQVKGNFGRGDAIAIIGVEGREVARGLAGYDAEEARLIIGHKSNEIETILGYVGRAAMIHRDDLVMTGAAVKVKHAKKDEVHA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_BACTN
Sequence: MKYFEFTFHTSPCTETVNDVLAAVLGEAGFESFVESEGGLTAYIQQALCDENTIKNAITEFPLPDTEITYTYVEAEDKDWNEEWEKNFFQPIVIDNRCVIHSTFHKDVPQATYDIVINPQMAFGTGHHETTSLIIGELLDNELKDKSLLDMGCGTSILAILARMRGARPCIAIDIDEWCVRNSIENIELNHVDDIAVSQGDASSLVGKGPFDIIIANINRNILLNDMKQYVACMHPGSELYMSGFYVDDIPFIRREAEKNGLTFVHHKEKNRWAAVKFTY
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_CLOBB
Sequence: MNFNKKTIEDIQVKGKKVLVRCDFNVPLKDGVITDENRLNGALPTIKYLVENGAKVILCSHMGKPKGEPKPELSLAPVAKRLSELLGKEIKFAPDNTVVGENAKAAVAEMKDGDVVLLENTRYRKEETKNGEEFSKELASLAEIFVNDAFGTAHRAHCSTVGVTDYIDTAVCGYLIQKELKFLGNAVETPEKPFVAILGGAKVSDKIAVINNLLDKVDTIIIGGGMAYTFLKAQGYEIGTSLVEEDRLDYAKEMIAKAEEKSVKFLLPVDHRVAAEFKDVEATVTNDQNIPTGNMGLDIGPKTETVYANAIKDAKTVIWNGPMGVFEFENFNKGTIAVAKAMADSNATTIIGGGDSAAAVNILGFGDKMTHISTGGGASLEFLEGKVLPGISALND
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAA_SHIBS
Sequence: MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: PDXJ_PECAS
Sequence: MAELLLGVNIDHIATLRNARGTPYPDPVQAAFVAEQAGADGITVHLREDRRHITDRDVRILRETLQTRMNLEMAVTEEMLNIACEVKPHFCCLVPEKRQEVTTEGGLDVAGQQEKIDNAVARLSQANILVSLFIDADKRQIDAAVASGAAYIEIHTGAYADAPDDETRQHEFERIRDAATYAAAKGLKVNAGHGLTYHNVLPIAALPEMHELNIGHAIIGRAVISGLKDAVAEMKSLMREARR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTHR2_ARATH
Sequence: MKVIDKIQSLADEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEGGFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTVGWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAVTWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLVSLVENDYINGDIFAVFADL
What is the function of this protein?
The probable reversibility of the MTHFR reaction in plants suggests that they can metabolize the methyl group of 5,10-methylenetetrahydrofolate to serine, sugars and starch.
What are the official names of this protein?
Methylenetetrahydrofolate reductase (NADH) 2, AtMTHFR2.
What is the protein family that this protein belongs to?
Belongs to the methylenetetrahydrofolate reductase family.
Protein: LEU1_STACT
Sequence: MSHIQVFDTTLRDGEQTPGVSFSFDERLTIAKQLEKWGVDVIEAGFPASSQGSFDSVKAISETLTKTAVVGLARCKKSDIDAVYEATKDAKYPQLHVFIASSPIHLEHKLKMTQEELLENITENVSYGKSLFDVVQFSPEDATRTDLDFLVKCVQTAVDAGASIINIPDTVGFSYPSEFGNIFKVLIENVKSDHEVTYSAHCHDDLGLAVANSMAAIENGATRIEGAVNGIGERAGNTALEEVALGLYVRRDHYGIETNLKLDETKATSDLVASFAGIRVPRNKAIVGQNAFSHESGIHQDGFLKHPETYEIMTPQLVGIKSSELPLGKLSGKHAFAEKLKQLGYDITAEKQVELFKQFKSIADKKKNVSDHDVHALVQGHSHETNAAYQVETLQLQFVSEGVQSAVVVLKDHEGKEYPSAAIGTGSIVAVYNAVDQIFKAPSELLNYQITSVTEGSDAQAQVNVEIRIDGKTYYGIGVDHDVLLASCKAYVEANSNHLADTARKDGVVS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: NDPA_VIBC1
Sequence: MSLHLSNVILHQLCKNDQDELVVKLRPASLENDTSTENLVAELHRVFHSKAGKGFGSFQSDSEFQFWLQEMRKGERDFYDFSQISANRLKEELIKYPFADEGILVFAEYQSLATDYLFIGILPMNQSLKVTEGLDIDATDYLDITKMDIAARIDLSSYDTDRESNRYLSYIKGRVGRKVADFFLDFLQADVGLDTKQQNQVLMQAVEDFCADSKLEKQEANEYKKQVYNYCNEQIKSGDEVQISELSGELPPSQDGTSFMDFTKEQGYELEESFPGDRSTVRKLTKYVGAGGGLNISFDSLLLGERIFYDPETDTLTIKGTPPNLKDQLSRN
What are the official names of this protein?
Nucleoid-associated protein VIBHAR_03026.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RSMH_YERP3
Sequence: MVDNNKTVDNNYKHTSVLLDEAVKGLNIRDNGIYIDGTFGRGGHSRLILSQLGPEGRLIAIDRDPEAIEAAKQITDPRFSIVHGPFSDLAHYVRDLDLVGRIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPSRGLSAAEWLMKASADDIAWVLKTFGEERFAKRLAKAIVERNLTQPMTRTKELADLIANASPFRDKHKHPATRSFQAIRIYINSELEEIERALDGAHEVLAPEGRLSVISFHSLEDRIVKNFIRHHSRGPQVPAGLPLTEAQLRSMGGRTLKSVGKMMPGDAEIAENPRARSSVLRFAERIGE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_ALKEH
Sequence: MPRILGIDPGSRITGYGVVEGSGSAPRHVASGCVRLPTGPFPDRLRVLYRALSELLAQHRPEAAVVEQVFVSRNPDSALKLGQARGAAICACVNAGLPVAEYTPGEIKQALVGHGRAGKAQVGYMVRMLLRLDATPAEDAGDALAAALCHLHQADMQARLRRAGA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: KYNU_RAT
Sequence: MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.  Has a preference for the L-3-hydroxy form.  Also has cysteine-conjugate-beta-lyase activity.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MTLD_ASPOR
Sequence: MGKKAIQFGGGNIGRGFVAEFLHAAGYEVVFIDVMDSVINSLQQTPSYDVTEVSEEGESTKTITNYRAINSKTHEADVVQEIASADVVTCAVGPNILKFIAPVIAKGIDARTEERPVAVIACENAIGATDTLHGYIKQHTNPDRLETLSERARFANSAIDRIVPNQPPNSGLNVRIEKFYEWAVEKTPFGEWGHPDIPAIHWVDHLEPYIERKLFTVNTGHATTAYYAHKRGKKMIAEALEDPEIRETVHKVLEETASLIVSKHEISEQEQKEYVDKIVSRISNPYLEDNVERVGRAPLRKLSRKERFIGPASQLAERGQKFDALLGAIEMALRFQNVPGDEESSELARILKENSAEDATSQLTGLEKDHPLYSHVVERVSTVQQGSKSVL
What is the function of this protein?
Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase, M1PDH, MPD, MPDH.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: RUVB_BEII9
Sequence: MSKTPERLVTSEVRDEDMTEASLRPLTLADFTGQAAARQNLSVFIAAAKARREALDHVLFVGPPGLGKTTLAQIVARELGVNFRSTSGPVIAKAGDLAAQLTALEERDVLFIDEIHRLNPAVEEILYPAMEDFQLDLIIGEGPGARSVKIDLARFTLVGATTRAGLLTTPLRDRFGIPIRLEFYTIEELERIVLRGARVQGLALEKEGANEIAKRARGTPRIAGRLLRRVRDFAIVDGVESVTRTLADKALSLLDVDPIGLDQMDRRYLNVIALSFGGGPVGIETIAAALSEPRDAIEDIIEPYLIQQGFLQRTPRGRLLTPHAFRHLGLKEPVRETPQYGLFPDQSEED
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CR14_HORVU
Sequence: MAKSLAVALRATGGARVMRRAGREREGCSDTRCRCQRWRRRLQGFGLAAAGGNRYRNKHHYRPAGGDPWDPCYRPMIISTSCAGATRS
What are the official names of this protein?
Cold-regulated protein BLT14.
Protein: RL30_SORC5
Sequence: MKLRVRQKASNIGQVEHTRKIIKGLGLRGPGSEVVVANTPSFRGMVKKVLHLVEVEEVADGATSSKA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: BIOB_SYNS3
Sequence: MTEAVEVRHDWTRSEIEALLDLPLMDLLWRAQGVHRASNPGYHVQLASLLSVKTGGCEEDCAYCPQSMHHSSDVTGQPELQVAPVLERAKAAKQAGADRFCMGWAWREIRDGAPFEAMLQMVSGVRALGMEACVTAGMLTDGQAQRLAKAGLTAYNHNLDTSPEHYDKIITTRTFQERLETLERVRQAGVTLCCGGIIGMGETIGDRASMLQVLASINPHPESVPINALVAVEGTPLEELPPIDPIELVRMIAVTRILMPGSRVRLSAGREQLSKEAQILCLQAGADSIFYGETLLTTGNPAVEADRELLRTAGVQANWLSASEKLAA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RL17_SYNPW
Sequence: MRHQCRVPQLGRPADQRKAMLRGLTTQLIREGRVTTTKARAKALRDEAERMITLAKEGSLASRRRVLGYVYDKQLVHALFEKAPDRYSDRKGGYTRITRTVRRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SRP54_METAR
Sequence: MVLDNLGTSLKDALRKIANSGKIDKEVIDEVVKDIQRAMIQADVNVKLVMKLSSTIKNRALTEAPPAGMNSKEHVLRIVYTELVNIVGKATPVALQSQTIMMVGLQGSGKTTTSAKIARYFARKGLKPAVICADTYRPGAYDQLKQLCDKLGVGFYGEAGNKDAVAIVRNGLKEMAKYDVKIVDTAGRHALETDLIQEMKDIYGLTKFDHKLLVLDAAIGQQASEQARAFNDAIGITGVVITKLDGTAKGGGALSAVSDTNTSIAFIGVGETPDDMERFDPDGFISRLLGMGDLRALVERANEVLQKDDVNVEKMMQGKFTLNDMYDQLEAINKMGPLKQIMSMLPLGGLGGNITDDMYKMTQDKLKGYKVIMDSMTAAERDDPKLIGSSRIARVAHGSGKSPEEVRELLKYHKMMQKAMKGMKGGGPGGKMNMQKIMKQMGMK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: RL13_PARDP
Sequence: MKTYTAKPAEIEKKWILIDAEGVVLGRLASIVAMRLRGKHKPTFTPHMDMGDNVIIINADKVQMTGDKRDAKKYYWHTGHPGGIKHRTARQVLEGAHPERVVIKAVERMISRNKLGKQQMTNLRVYAGAEHPHEAQQPEVLDVKSMNAKNTRSA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RS9_SYNP2
Sequence: MNATATQDRPIYWGTGRRKASIARVRLVPGSGKVVVNNRSGEDYFNRIPGYLAVLKSPLETLGLESEYDILVNAHGGGLTGQADAVKLGVARALCELDPDNRQPLKIEGYLTRDPRCKERKKYGLHKARKAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.