PharMolix/UniProtQA huggingface dataset:
Protein: CET1_CANGA
Sequence: MSEHHSKRALSLDDLVNHDENDKSKLQKLADNESSVRSDDNRPGAIENIVNGNNSNSDLNSNGVIEEDTDTDDDVGGEFTFDNGITFDYDKQDRFSPEKKRIQARKKDTSKTTPSISNESPSNSKESSVPVDPLSSNISATDRKDSSEEKPDLTGPELVKEPDTNEYKRPSIQSITNAEDTTYNDHKAAGMEKTSNKHSLPNILSDSIDETVTEEHKPKTETEQTITEYQQENKQKDNVNESNSEETHDIKNDNMNQVEKIFQEKTSTLSKKNSVKKDLELLNEISASSKPNKYKNTPIWAQKWKPTVKALQNIDTNDFKIDNSILDIIPDDDLTKSVQDWVYATLYSIDPDLRPFIELEMKFGVLLESKSPDRVNPPVSSQAVYTDMDAHLTPNVDETVFKELSKYIQSLSEITENAGKFNVIEAQTKDAVYRVGTSTQRPRFLRMSSDVKTGRIGAFIEKRHISQLLIYSPKDSYDVKLSINLELPVPENDPPEKYQHQTPVSERTKERVSYIHNDSCTRFDITKVQNHNKGIKSNDVEITHEIELEINTPALIKAFDNIMTDSKEYATLIRTFLNNGTIVRRKLSSLSYEIFEGQKKIQ
What is the function of this protein?
First step of mRNA capping.  Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
What are the official names of this protein?
mRNA-capping enzyme subunit beta, mRNA 5'-phosphatase, mRNA 5'-triphosphate monophosphatase.
What is the protein family that this protein belongs to?
Belongs to the fungal TPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYC_TACVF
Sequence: MGQFISFMQEIPIFLQEALNIALVAVSLICIVKGLVNLYRCGLFQLMVFLVLAGRSCSEETFKIGMHTKFQEVSLSLSALLTNQSHELPMLCLANKTHLYLKSGRSSFKINIDSVTVLTRSEVNLTSINLTRSIDVFVHSPKLGSCFESDEEWVVAWWIEAIGHRWDQDPGLLCRNKTKTEGKLIQINISRADGNVHYGWRLKNGLDHIYRGREEPCFEGEQCLIKIQPEDWPTDCKADHTNTFRFLSRSQKSIAVGRTLKAFFSWSLTDPLGNEAPGGYCLEKWMLVASELKCFGNTAIAKCNQNHDSEFCDMLRLFDYNKNAIKTLNEETKTRVNVLSHTINALISDNLLMKNKIRELMSVPYCNYTRFWYVNHTLSGQHSLPRCWMIRNNSYLNSSEFRNEWILESDFLISEMLGKEYSERQGRTPITLVDICFWSTVFFTSTLFLHLIGFPTHEHIRGEGCPLPHRLNSMGGCRCGKYLPLKKPTIWHRRH
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: IMDH_RHITR
Sequence: MARIIETSTGLDALTFDDVLLQPGHSEVMPGQTNIATRIAQDIELNVPILSAAMDTVTESRLAIAMAQAGGMGVIHRNLTPVQQAEEVRQVKKFESGMVVNPVTIGPDATLAEALSLDEGPRHFRASPVVEKSHRLVGILTNRDVRFASDPEQKIYELMTRENLVTVKDGVQQHEAKRLLHTHRIEKXLVVDADSRFVGLITVKDIEKSQLNPHASKDAQGRLRAAAAISVGDDGYERAERLIDAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAIMSAVQAAQDQNIPIIADGGIKFSGDLAKAIAAGASAAMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGXVPYKGPVSGVLHQLAGGLKAAMGYVGGADLKDFQERATFVRISGAGLRESHAHDVTITPRKARIIPAQAADR
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: NDB28_ANDMU
Sequence: MNKKTLLVIFFITMLIVDEVNSFKIGGFIKKLWRSKLAKKLRAKGRELLKDYANRVINGGPEEEAAVPAERRR
What is the function of this protein?
Amphipathic peptide that displays potent antimicrobial activities against a range of Gram-positive and Gram-negative planktonic bacteria with MIC values in the range 5 uM to 10 uM (Ref. 2).  In more details, it is active on Listeria ivanovii (MIC=5 uM), Staphylococcus epidermidis (MIC=10 uM), Salmonella enterica (MIC=5 uM), Pseudomonas aeruginosa (ATCC 27853) (MIC=5 uM), Acinetobacter baumannii (MIC=5 uM), Klebsiella pneumoniae (MIC=5 uM), Escherichia coli (MIC=7. 5 uM), Salmonella typhimurium (MIC=7. 5 uM), Pseudomonas aeruginosa (ATCC 9027) (MIC=10 uM) (Ref. 2).  Is also able to prevent P. aeruginosa biofilm formation while showing weak hemolytic activity towards human erythrocytes (Ref. 2).  Probably induces bacterial cell death through membrane permeabilization (Ref. 2).  Moreover, shows DNA-binding activities (Ref. 2).  Also exerts potent selective cytotoxic and antiproliferative activity against three different prostate cancer cell lines (IC(50)=4. 4-7. 8 uM), compared to non-tumorigenic cell lines (IC(50)=59. 7 uM in Vero and 62. 5 uM in HUVEC cells) (Ref. 1).  This peptide possibly exerts its cytotoxic activity through a necrotic mode of cell death (Ref. 1).
What are the official names of this protein?
Mauriporin, Non-disulfide-bridged peptide 2.8, NDBP-2.8.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: RL39_METMJ
Sequence: MSKLMKGRKIRLAKACEQNRRVPAWVMIKTNRAVASHPKRRNWRRSSLKV
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: GLMM_SHEON
Sequence: MSERKFFGTDGIRGKVGSGQMTPELALKLGWAAGRVLSRSGTKKVIIGKDTRISGYMFESALEAGLSAAGLNVMLMGPMPTPAVAYLTRTFRAEAGVVISASHNPYYDNGIKFFSTDGSKLDDNLELEIEAELEKPLVCVESHLLGKVSRIEDARGRYIEYCKGNFPADQTLTGLKIVVDCAHGATYHIAPAVFRELGAEVIAIGDKPNGVNINDKVGATSMAKICETVLAETADLGIALDGDGDRIMMVNSKGEVIDGDQILYILACDAKARGVLRGGVVGTLMSNLGLDLALQALDIPFARSKVGDRYVMELLKELDWRIGGENSGHILNLDHGTTGDGIVAGILVLAAMRRQNATLEQLTAPMEMLPQVLVNVRFEGEHDPLSSDKVKAAQAQVESELGVRGRVLLRKSGTEPLIRVMVEGDDHNTVLAHANLIADAVKSAS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: SYA_SHESA
Sequence: MYQTTAALRSAFLEFFRSNGHQVVDSSSLVPGNDPTLLFTNAGMNQFKDVFLGMDKRSYTRATTAQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEDAIRFGWTFLTEVLKLPKERLCVTVYQTDDEAFEIWNKKIGVAAENIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGRPGSPEEDGDRFIEIWNIVFMQYNRQASGEMLPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFRALIAKAAEIIGVTDLSNKSLRVIADHIRSCAFLVADGVMPSNEGRGYVLRRIIRRAVRHGNKLGATEAFFYKLVPTLIEVMGDAAKGLADTQVIVEKALKAEEEQFARTLERGLGILDSALNELQGDTLDGETVFKLYDTYGFPVDLTADVCRERNIIVDEAGFEVAMAEQRSRAQAAGNFGADYNAALKIDAETAFCGYSELTGNAKVTALYLNGESVSAISAGDDAVVVLDVTPFYAESGGQVGDKGVLVAQGIEFAVSDTQKFGQASGHKGTLTAGSLSVGQVLEAKVDKKLRHRTQLNHSVTHLLHAALRQVLGTHVTQKGSLVDPERLRFDFSHFEAVKPAELKQVEELVNTQIRRNHELKVAEMAIDEAKEKGAMALFGEKYDAQVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEGGIAAGVRRIEAVTGAAAMAYVAQQQAQLEEAAALLKGDTQSVVAKLKAQLDKMKQLEKDMQQLKDKLAAAASADLAGDAVVVNGVNVLIKKLEGVEAGALRGLQDELKQKLKSAVILLGVAQEGKVNLIAGVSNDLVGKVKAGELVAMVAAQVGGKGGGRPDMAQAGGSQPENLDAALSQVLPWITERLA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17E_HALMA
Sequence: MAIKPAYVKKTGTLLMERYPDAFGADFEHNKDVVEELTNIESKGVRNRIAGYVTRKMNNPVEA
What are the official names of this protein?
30S ribosomal protein S17e, Ribosomal protein HS26.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: MMP9_MOUSE
Sequence: MSPWQPLLLALLAFGCSSAAPYQRQPTFVVFPKDLKTSNLTDTQLAEAYLYRYGYTRAAQMMGEKQSLRPALLMLQKQLSLPQTGELDSQTLKAIRTPRCGVPDVGRFQTFKGLKWDHHNITYWIQNYSEDLPRDMIDDAFARAFAVWGEVAPLTFTRVYGPEADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGAGVQGDAHFDDDELWSLGKGVVIPTYYGNSNGAPCHFPFTFEGRSYSACTTDGRNDGTPWCSTTADYDKDGKFGFCPSERLYTEHGNGEGKPCVFPFIFEGRSYSACTTKGRSDGYRWCATTANYDQDKLYGFCPTRVDATVVGGNSAGELCVFPFVFLGKQYSSCTSDGRRDGRLWCATTSNFDTDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPLYSYLEGFPLNKDDIDGIQYLYGRGSKPDPRPPATTTTEPQPTAPPTMCPTIPPTAYPTVGPTVGPTGAPSPGPTSSPSPGPTGAPSPGPTAPPTAGSSEASTESLSPADNPCNVDVFDAIAEIQGALHFFKDGWYWKFLNHRGSPLQGPFLTARTWPALPATLDSAFEDPQTKRVFFFSGRQMWVYTGKTVLGPRSLDKLGLGPEVTHVSGLLPRRLGKALLFSKGRVWRFDLKSQKVDPQSVIRVDKEFSGVPWNSHDIFQYQDKAYFCHGKFFWRVSFQNEVNKVDHEVNQVDDVGYVTYDLLQCP
What is the function of this protein?
Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity).  Could play a role in bone osteoclastic resorption (PubMed:8132709).  Cleaves KiSS1 at a Gly-|-Leu bond (By similarity).  Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:23142597, PubMed:32883094).  Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments.  Degrades fibronectin but not laminin or Pz-peptide (By similarity).
What are the official names of this protein?
Matrix metalloproteinase-9, MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PSTB2_MYCBO
Sequence: MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NEF_HV1VI
Sequence: MGGKWSKSSIVGWPAVGERMRQTPTAAEGVGAVSRDLDRRGAITSSNTRTTNPDLAWLEAQEEEEVGFPVRPQVPVRPMTYKAAVDLSHFLKEKGGLEGLIYSKKRGDTLDLWVYHTQGYFPDWQNYTPGPGIRYPLTLGWCFKLVPVDPEEVEKANEGENNCLLHPMSQHGMEDEDREVLRWKFDSSLALRHIARERHPEFYQD
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: PYRB_BACC4
Sequence: MSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDVRHSRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVEREKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SCNAA_ONYTO
Sequence: MEFPIGSVGTTNFRRFTPESLAEIEKQIAAHGAAKKARAKHGERKGQDEKPRPQLDLKACNQLPRFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATWALWLFSPFNLIRRTAIKVSVHAWFSIFITITILFNCVCMTQNDLPEKIEYAFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIKRSTDPHNAYNFSSQMADNFYIKNGTTEPLLCGNGSDAGHCPSGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATIAEIEAKEKKFQEALEVLQKEQEVLAALGIDTTSLHSHNGSPLAPKNANERKHRIKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRASHSSVFHFRAPSQDVSFPDGITDDGVFHGDHESHRSSLLLARGAGQAGPLPRSPLASSPNPGPGHREEGQLTAPTGELTTGAPEDLALEAAGQKKNFLSAEYLNEPFRAQRAMSVVSIMTSVIEELEESKLRCPPCLINLAQKYLIWECCPKWMKFKMVLFELVTDPFAELTITLCIVVNTIFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNVFDCVIVTVSLLELSIAKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLGEDYGCRKDGTALWNEGQLRWHMCDFFHSFLVIFRILCGEWIENMWVCMQVSEKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARTQAFGQRASQAISSYFSSHCRLRWPKVGSQLGVKPSLTSSKAEHHITADAVNTAVGTSAKPALSGPKEDPRDFITDANVWVSVPIAEGESDLDELEEDIEQNSQSSWREESPKGQQDQLWQIQRCEDHQVPNSPGSGMSSEDLASYLGERWKSEATPQVPAEGVDDTSSSEGSTVDCPDPEEILKKIPELADDLEEPDDCFTEGCTRHCPCCKVSTSKFPWTTGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEQKPRVKSMLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILDYSDVASLKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCIDTSNNPFSVVNSTIVNNKSECRNQNHTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREINSQPQWEDNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDGQSEEKTKILGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIGSLVFSAILKSLESYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVVEEAGIDDMFNFQTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLSNNNTSKGNCGSPTVGIVFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRWKQEDISATVIQKAYRSYVLQRSLTLSNPLRVPRAEDDDAPLPGEGYVTFMANDSGRLPDKSETTSATSFPPSYDSVTRGLSDRVNISTSNSMHNEDEVTSKEGDSPGPQ
What is the function of this protein?
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient.  Plays a role in neuropathic pain mechanisms.
What are the official names of this protein?
Sodium channel protein type 10 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=It can be translocated to the cell membrane through association with S100A10.
Protein: ODC1_YEAST
Sequence: MTSIDNRPLPFIYQFTAGAIAGVSELLVMYPLDVVKTRMQLQVTTKGHPAVVAAKAAVDHYTGVMDCLTKIVKKEGFSHLYKGITSPILMEAPKRAIKFSGNDTFQTFYKKIFPTPNGEMTQKIAIYSGASAGAVEAFVVAPFELVKIRLQDVNSQFKTPIEVVKNSVVKGGVLSLFNGLEATIWRHVLWNAGYFGIIFQIRKLLPAAKTSTEKTRNDLIAGAIGGTVGCLLNTPFDVVKSRIQRSSGPLRKYNWSLPSVLLVYREEGFKALYKGFAPKVMRLAPGGGLLLVVFTNVMDFFREVKYGKKQ
What is the function of this protein?
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria.  Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate.  The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.
What are the official names of this protein?
Mitochondrial 2-oxodicarboxylate carrier 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPF_ALIF1
Sequence: MNATLLGQAIAFTLFVWFCMKYVWPPIMEAIEERQKKIADGLSAAERAAKDLDLAQANASDQLKEAKRAATEIIEQANKRKSQILDEAREEALVERQKILTQGEAELESERNRARDELRKQVATLAVIGAEKILERSIDVEAQKDILDNITAKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CLPX_SHIB3
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: Y867_MYCCT
Sequence: MTKYLFSDFDNTLRNSKVKNSLRIDQKDLDFIKEFQKNNKLIVSTGRPYKQLKEHLLNEYNLMPDYFIVNTGAMICDNKGRILYKKTIDNKIKIQLLNFLKTIVNQIDVIVFATSENESFLFHKNWSKDVEKFFFGLEKLNKTLDYLYDKDLLCLKIECSQETWNKIEDFINKNNLEVNITFNSINNRLFNEIHAFKVSKGQAIKGLQEKLDISSDDIIVAGDDYNDISMFEMFYKNSYMCKHKHNENIRNKARYLIDNIWEIKY
What are the official names of this protein?
Uncharacterized protein MCAP_0867, ORF R4.
Protein: LON_UREP2
Sequence: MKKPILISRAIVVLPYETTTIEVGRPKSIQAIDLAKQSSSKEIIIISQKDIDTDEVVNFDELYKVGTLVKIKSIIDNFDEGYSIEVEGLKAVYINNENDVIDAIEYEYEDVITNPILSNKDEIAINGINSEIFNIINKRSRHKNINFDNMHALISLEKEKFAYLAAATYINDYDNEISEKTIEDRINILLQPNLLLVHETILHLLFDQLVDKRVIEDEVEKTITDKINNNFQKQQREFYLREKLKVVKEQLGELSSREEDADKIRAKIEDLELPPNVKERALAELNRFENAMSSNESSVIKSYLDWLLDLPWTQQGVDNTDLMSVRTHLDDNHYGIEKVKERILEYLALRMRNPNLKGPIICLVGPPGVGKTSLVTSIAQALNKKFVKVSLGGVRDESEIRGHRKTYVGAMPGRIIKGMKKAGVINPLFLLDEIDKMTSDQRGDPAAAMLEVLDPEQNKNFSDNYIEEEYDLSKVMFMATANYYQQIPYALIDRLEVIELSSYTAIEKREIAKSHLLKRIFMDAKLNENELIFTDDALDFIINHYTKEAGVRELDRQLGHIVRKYIVETYKNKNNQSPLNLKVDEAMIIKYLGKIKFDFNKKEETTIPGIVNGMAYTAAGGDLLPIEVNHSTNGKGGNVTITGNLEKTMNESVSVALGFVKANADKYGIDTKKVSFKEIDIHVHVPSGGIPKDGPSAGIAITTAIISSLSQRPVRTTLSMTGEIMLRGNVGIIGGVKEKVISAYRAGVREIILPIDDERYLEDVPKYILDDIKIHLVKHYDEVYNIVFGEK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KNOX4_MAIZE
Sequence: ELKYQLLKKYSGYLSSLRQEFSKKKKKGKLPKEARQKLLHWWELHYKWPYPSETEKIALAEATGLDQKQINNWFINQRKRHWKPS
What is the function of this protein?
Probably binds to the DNA sequence 5'-TGAC-3'.
What are the official names of this protein?
Homeobox protein knotted-1-like 4.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCST_PYRAB
Sequence: MAKRVHLFDWHKEHAKKIEEFAGWEMPIWYSSIKEEHLAVRNAVGLFDVSHMGEIYFRGKDALKFLQYVTTNDISKPPAISGIYTLVLNERGAIKDETLIFNMGNNEYLMICDSDAFEKLYAWFTYLKKTIEQFTKLDLEIELKTYDIAMFAVQGPKARDLARDLFGIDINEMWWFQARWVELDGIKMLLSRSGYTGENGFEVYIEDANPYHPDESKRGEPEKALHVWERILEEGKKYGIKPAGLGARDTLRLEAGYTLYGNETKELQLLSTDIDEVTPLQANLEFAIYWDKDFIGKDALLKQKERGLGRKLVHFKMVDKGIPREGYKVYANGELIGEVTSGTLSPLLNVGIGIAFVKEEYAKPGIEIEVEIRGARKKAITVTPPFYDPKKYGLFRET
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Probable aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RUVA_STRU0
Sequence: MFDYIKGQLTKITAKYIVVEANGLGYIIYVANPYSFSDSVNQTLTIYLHQVIREDAHLLFGFHTENEKDVFLKLISVSGIGPMTALAIVAVDDNEGLVAAIDNSDIKYLMKFPKIGKKTAQQMILDLSGKFVTIPEGGQAQQMPKAKGNQQLDEAIEALLALGYKATELKKIRAFFEGTDDTAEQYIKSALKMLMKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: KLDC3_MOUSE
Sequence: MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYSLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons.  The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (By similarity).  May be involved in meiotic recombination process (PubMed:12606021).
What are the official names of this protein?
Kelch domain-containing protein 3, Testis intracellular mediator protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Also found in meiotic chromatin.