PharMolix/UniProtQA huggingface dataset:
Protein: RON_MOUSE
Sequence: MGLPLPLLQSSLLLMLLLRLSAASTNLNWQCPRIPYAASRDFSVKYVVPSFSAGGRVQATAAYEDSTNSAVFVATRNHLHVLGPDLQFIENLTTGPIGNPGCQTCASCGPGPHGPPKDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPRGKALHLAAPACLFSANNNKPEACTDCVASPLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVYSFHSGDFVYFLTVQPISVTSPPSALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRRGAPEGTQPYPVLQAAHSAPVDAKLAVELSISEGQEVLFGVFVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSSSLLSRGLDFFQTPSFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTVDGRVLQVEIARSLNYLLYVSNFSLGSSGQPVHRDVSRLGNDLLFASGDQVFKVPIQGPGCRHFLTCWRCLRAQRFMGCGWCGDRCDRQKECPGSWQQDHCPPEISEFYPHSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQITVGQSPCRLLPKDSSSPRPGSLKEFIQELECELEPLVTQAVGTTNISLVITNMPAGKHFRVEGISVQEGFSFVEPVLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVNEEQILCVTPPGAGTARVPLHLQIGGAEVPGSWTFHYKEDPIVLDISPKCGYSGSHIMIHGQHLTSAWHFTLSFHDGQSTVESRCAGQFVEQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRFLPPPSPLRAGLVELKPEEHSVKVEYVGLGAVADCVTVNMTVGGEVCQHELRGDVVICPLPPSLQLGKDGVPLQVCVDGGCHILSQVVRSSPGRASQRILLIALLVLILLVAVLAVALIFNSRRRKKQLGAHSLSPTTLSDINDTASGAPNHEESSESRDGTSVPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVKQVVASLLGDHYVQLTAAYVNVGPRAVDDGSVPPEQVQPSPQHCRSTSKPRPLSEPPLPT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand.  Regulates many physiological processes including cell survival, migration and differentiation.  Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.  Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site.  Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages.  Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
What are the official names of this protein?
Macrophage-stimulating protein receptor, MSP receptor, Stem cell-derived tyrosine kinase, p185-Ron.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y619_CITBB
Sequence: MPSFDIVSKVDMQEVDNAINQTVKEIAQRYDFKGSKCEVTLEKENIKVLADDDFKLKAVIDILQSKFIKRNISPKSLQYGKAEQASGSMVRQIITLQVGISKEKAKEIGQVIKETKLKVQSQIQDDQLRVTGKNIDDLQEVIRVLKGKDLDIDMQFVNFRS
What are the official names of this protein?
UPF0234 protein Gbem_0619.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: CCD25_DICDI
Sequence: MVLYFKLIDPEYICYMGIDKFENEDLIKYGWPEDVWFHVNDLSSAHVYLRLRKGETWNDIPANILEECCQLVKQNSIQGCKEASVDIVYTPWANLKKTAGMEAGQVLYHNEREVKYVRNVRKDSKIINRIEKTREKREVDLMHERDSRDKSERHEKRKEQEEKRRAEKKAYEEKQKMEDIKKYTSIMKTDNMKFNKYNPTDEDDFM
What are the official names of this protein?
Coiled-coil domain-containing protein 25 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCDC25 family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: C7H23_PANGI
Sequence: MADKYGPIFSLQLGIHKTIVVSSWAVAKECFTTHDKVFLTRPKSLAGKHMGYDHSVFLFLAYGPYWRDTRKLLIVELLSNRRLDVLKHVRESEVNSFVREMYEQWISNGGGGSKAVVEMKERFGYLTMNVILRMVAGKRYSGTEVYSDEARRFQKALGDLLHLVVLSMVSDAVPLFGWIDALRGYTGEMKNTAKEIDHVLGRWLKEHRQKRETLSINESEHDFIHGMQSVMDGSQFTEHDTDKAI
What is the function of this protein?
Probable heme-thiolate monooxygenase.
What are the official names of this protein?
Cytochrome P450 CYP82H23.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RECR_LIMRD
Sequence: MIQYPEPLAKLIESYTKLPGIGQKTATRLAFYTLSMQEDDVTNFAKSLLSAKRDLHNCSICGNITEDDPCPICRDKTRDHSQILVVEQSQDVMAMERMHEYHGLYHVLHGVISPVAGTGPEDINITSLLKRLKKDDEVKEIIIATNASSDGELTAGYLAKLIKPAGIKVTRLAHGLSVGADIDYADEMTLFKAVQGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RECX_HAEDU
Sequence: MPKYTAVNYLIYLLSKRDYSEYDLRNKLIQKQYDTDEIEHAIQQAQLNNWQNDERYCASFIRYRSQQGIGPRRLKQELRLKGIKDYLISEQLQNTEIDWFSLAELLFEKKRPLDWNIKVKQKMWRFMLSRGFYNEHFSHLMDLEEVSKEYE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_PSEA8
Sequence: MPELPEVETTRRGIAPYLEGQRVERVIVRERRLRWPIPEDLDVRLSGQRIVSVERRAKYLLLGAEAGTLISHLGMSGSLRLVESGTPASRHEHVDIELASGMALRYTDPRRFGAMLWSLAPLEHELLRNLGPEPLTDAFAGQRLFELSRGRSMAVKPFIMDNAVVVGVGNIYASEALFAAGIDPRKPAGSISKARYLRLAEEIKRILAIAIERGGTTLRDFVGGDGQPGYFQQELFVYGRGGEFCKVCGSTLREIRLGQRASVYCPRCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PTSS2_DANRE
Sequence: MAKGEWKRSGADDLPLPGRSECEVFDDGTNTFFWRAHTVTVLFILTCALVYVTLLEETPHDTAYNTKRGIVASILVFLCFGVTQAKDGPFTRPHPAYWRFWLCVSVVYELFLIFILFQTVHDGRQFMKYIDPKLGVPLPERGYGGNCLIYDPGHPTDPFHNIWDKMDGFVPAHFLGWYIKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLGWLSMKPYQWQGLWNIPTYKGKIKRIAFQFTPYSWVKFEWRPASNLRRWLAVLGIIFMFLLAELNTFYLKFVMWMPPEHYLVLFRLVFFVNVGGVAMREIYDFMDDPKFHKKLGQQAWIVAAITVTEFLIVVKYDPNTIMLPIPFFITQCWILGIALILVWTLWRFFIRDITLRYKETRRRRQEVSSERDGSSSAPSGRSKLNGSMDSVRHRKS
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity).  Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity).  Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 2, PSS-2, PtdSer synthase 2, Serine-exchange enzyme II.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: MIS12_ARATH
Sequence: MEGSKSEAVFDSMNLNPQIFINEAINSVEDYVDQAFDFYARDASKSLKIKGSDKQKSQALSNGIARVRGLLLSVIDNRLKLWESYSLRFCFAVPDGFVLPKSEESSSVHQDGLYDLELDAELDSLRDKLNVVGKRSVELDSELQALERSSVSRERSLRLVNEALELYDESSMDEIFKEMTKMASELRASVERLKTRRMKASESAKVKRLKNHGKEFSAMTFDGKLEDLEKFQAELRKM
What is the function of this protein?
Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable).  May play a role in the modulation of centromere during meiosis (PubMed:21695238).
What are the official names of this protein?
Protein MIS12 homolog, Protein MINICHROMOSOME INSTABILITY 12, AtMIS12, Protein MIS12-LIKE.
What is the protein family that this protein belongs to?
Belongs to the mis12 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Note=Localizes at centromeric regions throughout the mitotic cell cycle. Co-localizes with CENH3 during the cell cycle, from interphase to anaphase (PubMed:16331414). Localized at centromeres in meiotic cells (PubMed:21695238).
Protein: YKIC_ECOLI
Sequence: MNYKAFTQIAIDLLSAKLCNCTQAIMTHIIASFLAFMFF
What are the official names of this protein?
Protein YkiC.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FOLD_BACC2
Sequence: MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIELPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELSKLADILIVAVGRPKMITADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLNVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PYF1_PENMO
Sequence: RARPRF
What is the function of this protein?
May act as a neurotransmitter, neuromodulator or neurohormone.
What are the official names of this protein?
Peptide tyrosine phenylalanine 1, Pem-PYF1.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: VP41_BPAPS
Sequence: MKTFTPRPYQHLIINHLLDIKRSNVWAGMGMGKTAATLTALENLYLSGSETKPTLVLAPLRVAQSTWPDEALKWSHLRNIEVQPIIGSAKARIAALKNTHASVFTVNYDNLVWLVDILGDTWPFGTIIADESTRLKSFRLRKGGKRTAALAKIAHKSVHRWVNLTGTPSPNGLMDLWGQAWFVDQGERLGRTYNAFTSRWFKRIQLPGQQWSRFEPLGFAHLQIPLALSDVTLSLDAADWFDIDEPIHNVINVELPAKARAHYHAMEKELFLELGESAIEALNAAAKTIKILQIASGAIYSDDNRNWTEIHDAKIQALESIVNESGGTPVLVAYHWKHDLERLLKAFPKGKNLDANPRTLTDWNNGKIPLLFAHPASCGHGLNLQDGGNILVFFSHWWDLEQYQQIIERIGPTRQAQAGHNRPVFIHHIVAKDTLDEVVMERRNSKRAIQDLLLEAMKRK
What are the official names of this protein?
Putative protein p41.
Protein: PLSY_STAAT
Sequence: MMIIVMLLLSYLIGAFPSGFVIGKLFFKKDIRQFGSGNTGATNSFRVLGRPAGFLVTFLDIFKGFITVFFPLWLQVHADGPISTFFTNGLIVGLFAILGHVYPVYLKFQGGKAVATSAGVVLGVNPILLLILAIIFFIVLKIFKYVSLASIVAAICCVIGSLIIQDYILLVVSFLVSIILIIRHRSNIARIFRGEEPKIKWM
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACEA_SOLLC
Sequence: MAASYSVPSMIMEEERRFEAEVAEVQAWWNTERFRLTKRAYSARDVVALRGTMRQSYASNELAQKLWRTLKTHQANGTASRTFGALDPVQVTMMAKHLDTIYVSGWQCSSTHTSTNEPGPDLADYPYDTVPNKVEHLFFAQQYHDRKQREARMSMCREERARTPFIDYLKPIIADGDTGFGGATATVKLCKLFVERGAAGVHIEDQSSVTKKCGHMAGKVLVAVSEHINRLVAARLQFDVMGTETVLVARTDAVAATLIQTNVDTRDHQFILGASNPNLKGKGLATHLSEAMAAGKTGPELQAIEDNWLGMAELKTFSQCVTDAIKKMNLAEYEKQRKLNEWMNHSSYEKCLSHEQAREVAERLGLPNLFWDWDLPRTREGFYRFQGSVEAAIVRGWAFAEYCDLVWMETSSPDMVECTKFSQGVKTLRPELMLAYNLSPSFNWDASGMNDNQMMDFIPRIAKLGYCWQFITLAGFHADALIVDTFAKDFARRGMLAYVEKIQREERSNGVDTLAHQKWSGANYYDRVLRTVQGGITSTAAMGKGVTEEQFEEKWTRTGATNLGDGSVVIAKARM
What is the function of this protein?
Involved in storage lipid mobilization during the growth of higher plant seedling.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratsysase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: MUTS2_GEOKA
Sequence: MQPKVLHTLEFDKVKEQLAEHASSPLGLEKIDALMPSSDLEEVAAWLDETDEAAAVLRLAGYVPLDGVVDIRPHLKRAAIGGTLSPQELLEVAATSAASRQMKRLIAGLYDEHGGLERLFRYADTLAEAPELEHDVRRSIDDHGEVLDAASDRLRSLRGQIRSVEARIREKLESIIRSPSAQKRLSDAIITIRNDRYVIPVKQEYRGAYGGIVHDQSASGATLFIEPQAVVELNNALREARAKEKQEIERILRELSAKVAEQAEPLARTVEALAALDFAFAKAKYARRLQAAKPAVNSRGYLRFLQARHPLLDQEKAVPNDIELGGDYTTIVITGPNTGGKTVTLKTIGLLTLMAQAGLFIPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIVDILRHVDGESLVLFDELGAGTDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYKLLIGIPGRSNAFDISRRLGLDERIIERAKAQVSAESHNVENMIASLERSKKQAEEDEARARAALEEAERLRAEWEQKWEELEEEKAERLAEATQKAADIIRAAEREAERIIQELRRLQKEKQAEVKEHELVEAKQRLAAAMPKVEKRKKAKKAASRHVFQPGDEVKVTSLNQKGYLIEKVSDDEWQVQLGILKMKIHERDLEYIGSAPAKDVTPIATVKGKDAHVSLELDLRGERYEDALIRLEKYLDDAVLAGYARVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGEANEGGTGVTIVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: Y085_NPVOP
Sequence: MQILLVVRLVLLWLGGLSAAALGITETAASAHFGTRIGWGKFEQDPNIYYNETQY
What are the official names of this protein?
Uncharacterized 6.1 kDa protein.
Protein: CYB_MACGD
Sequence: MAMNIRKTHPLIKIVNNSLIDLPTPSNISIWWNFGSLLGLCLIIQILTGLFLAMHYTADISSAFSSVAHICRDVNYGWLIRNTHANGASMFFICVYLHIARGFYYGSYLYKETWNIGVIILVLLMATAFVGYVLPWGQMSFWGATVITNLLSALPYIGDMLVQWIWGGFSVDNATLTRFFTFHFLLPFVIVALTMVHLLFLHETGSNNPIGLDSNMDKIPFHPYYSYKDLLGFFMLLLLITFLALFMPNLLGDTENFIPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSIFILLLVPMLHTSKQQSLIFRPITQILFWLLVANTIILTWIGGQPVEQPFIIIGQIASITYFSFFLILFPLAGWWENKMLKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HIR2_CANGA
Sequence: MRLLKYPLEGISGNVTSLVTIDAEYVVVCGSRGDIQVWHQQQLLDTAFDRCTLETLKPKYSFTFELKDDEDELVFAMGDRDCLYLGTEHSVYSYSGWLKALESGHTTLENKLIYTTVSQSIITDVKWDSLLDILFVLTDRPCKIHLFDTRSANKKEITSIALDKNSKPLTGVVDPSGAGTFTVLTSDRSIVVYHINRTGDYKEVKKLSQHVLVYPLHYKITMPPQADFLPIINSLKGSSGAAGSTATVLLNRNENYKVMSTLVPSASSNTKVLVHSPKMYEKANLKRGTISRYNLVATSTNTDGSIMIWNTKRGKPLFAPLNISDSAINDMIWSSNGLTLFAVSNDNVLYTFAFLQDDLGKTVPMEEIENIRQSNIIKEPLPIAYVITASDGLGDISTSKNQGLGVAADNSSNILSTDTNTNEKNLSTVNTTEPQTNSQSSSYNNKPESKLDSSKSEITSADSSDEKAKNLEARPIEAKSKKILNGKNLESKSSSVTTSDNIQKKVEDSKSNVSVTATEKKTKPDKKSIKSENGESKVNKAQNTISPKESNTTDNKSTTPDFKNPSYQVPKDLKRKPKEDALGNAVTKRAKKDLEPVDFLDTGLLLPNVAFSRVRLSTPLIRMNIDCTSSNDSKILLNIRNGSGNEQKPTIVKLLDKTVTPERTLFQDFIPKFVSLATSGDDFWACSSEDGTLYIFNDVGRKIIPPLTIGVPISFLEACGKYLLCVSSIGELYCWNIASSKLEFPVTTIFPLLSPSIRYSDDILTRAENITMCSVTNNGFPIATLSNGDGYMYDKNMETWLLVSDGWWAYGSQYWDSTNNSNLIPDSSTKPTEGQSSTEISKASIVTLLEKKTNNELTRKGRIKNLRRFARTILMKEGFENIEEIVTLSHLENKLLVTLRLEEQHEFKKLIKLYAVKLGELGYVDRLRDLFAWIISDSNDNGDLIPGINRKELVKTLLTACADLRSVQRVTIDYADMLGYLPNDIFFDCESQNDTGK
What is the function of this protein?
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
What are the official names of this protein?
Protein HIR2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAAA_LISM4
Sequence: MKVLVNNHLVEREDATVDIEDRGYQFGDGVYEVVRLYNGKFFTYNEHIDRLYASAAKIDLVIPYSKEELRELLEKLVAENNINTGNVYLQVTRGVQNPRNHVIPDDFPLEGVLTAAAREVPRNERQFVEGGTAITEEDVRWLRCDIKSLNLLGNILAKNKAHQQNALEAILHRGEQVTECSASNVSIIKDGVLWTHAADNLILNGITRQVIIDVAKKNGIPVKEADFTLTDLREADEVFISSTTIEITPITHIDGVQVADGKRGPITAQLHQYFVEEITRACGELEFAK
What is the function of this protein?
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine.  The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.  The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism.  This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components (By similarity).
What are the official names of this protein?
D-alanine aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, DAAT, D-aspartate aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: KDUI_HALH5
Sequence: MENRYATSPEDVKRYTTDKLRQEFLVESLFTPGEIQMVYTHFDRTVIGGAIPMKEPLALDAGDFLKTDYFLERREVGIINIGPKGKVIVDGDEYTLNKRDCLYIGLGKRDVSFHSEDSSNPARFYFVSALAHHEYPTKVLPIEEAVPTKLGSDAESNNRTIYKYIHSEGIQSCQLMMGMTLLEPNNMWNTMPAHIHDRRNEVYLYFDMEDDSRVFHFMGQPHETRHLVVKNEQAVISPPWSIHSGVGTANYTFIWAMAGENYTFTDMEFIKMEDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: CH602_NOSS1
Sequence: MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVASKTKDVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMIAQAVEKVTKDGVITVEESKSLTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVARLGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQKITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNATKAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAATGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFIT3_PANTR
Sequence: MSEVTKNSLEKILPQLKCHFTWNLFKEESVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYVWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNNPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKAPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDCAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
What is the function of this protein?
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication.  Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription.  Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27.  Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation.  IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels.  Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21.  Can negatively regulate the apoptotic effects of IFIT2 (By similarity).
What are the official names of this protein?
Interferon-induced protein with tetratricopeptide repeats 3, IFIT-3.
What is the protein family that this protein belongs to?
Belongs to the IFIT family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: RR8_ZYGCR
Sequence: MGNDTIGSMITCIRNGNLSKAKTVEVPATQITRSIANILLQEGYIANVRERQYNAIRMLVITLKYQTKTRKPHITIIKYISKPGLRVYSNHQDIPQFLGEMGIVILSTSKGIMMHREARAQKVGGEVLCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYS_BACCN
Sequence: MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQISMLKREKKDAEALILEMREVGEKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDDNVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTGSRFVFYKGAGARLERALISFMLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMHRDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELEKLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGKTVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STMN1_MOUSE
Sequence: MASSDIQVKELEKRASGQAFELILSPRSKESVPDFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD
What is the function of this protein?
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules.  Prevents assembly and promotes disassembly of microtubules.  Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity).  Involved in the control of the learned and innate fear.
What are the official names of this protein?
Stathmin, Leukemia-associated gene protein, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.