PharMolix/UniProtQA huggingface dataset:
Protein: GLMU_PARP8
Sequence: MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTAVAASDVQFALQEQQLGTGHAVQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDGYGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQKIAEINTGIVVMPTKRLDGWLSSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVADDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIGAGTRIDAYTHIEGAQVGAQAVLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHLSYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVGSDTQLVAPVRVGRGVTIAAGTTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR5B_MOUSE
Sequence: MATEHLPAERAQSLLSAPRREEEPQKPNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAALENDKTIKVWSSDC
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
What are the official names of this protein?
WD repeat-containing protein 5B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR5/wds family.
Protein: PYRD_BRUMB
Sequence: MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYSGLIYRGPGLPGEILRGLSTAIKYEGVSSIAELRDRDTKEWAARKLIS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS5_RHOOB
Sequence: MPGRQRRDGGSGPAGQNGPNTGDNRGGGDRRGGGRDDRRGGQSAEKSNHIERVVTINRVSKVVKGGRRFSFTALVIVGDGNGLVGVGYGKAKEVPAAIQKGVEEARKSFFRVPMIGSTITHPVQGEAAAGVVMLRPASPGTGVIAGGAVRAVLECAGIHDILSKSLGSDNAINVVHATVAALKGLQRPEEVAARRGLALEDVAPAGMLRARAQAGSVK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: NUSB_ECO57
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SMI19_MOUSE
Sequence: MAGSYGVMADDGSIDYTVHEAWNEATNVYLIVILVSFGLFMYAKRNKRKIMRIFSVPPTEGMLSEPSFYDTVSRIRLRQQVEAHPVSRKYEYQQPQSQADSVQLSLE
What are the official names of this protein?
Small integral membrane protein 19.
What is the protein family that this protein belongs to?
Belongs to the SMIM19 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AROA_BRUMB
Sequence: MSHSACPKPATARHSQALTGEIRIPGDKSISHRSFMFGGLASGKTRITGLLEGEDVINTGRAMQAMGARIRKEGDVWIINGVGNGCLLQPEAPLDFGNAGTGARLTMGLVGTYDMKTSFIGDASLSKRPMGRVLNPLREMGVQVEAAEGDRMPLTLIGPRTANPIAYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLQGFGADLTVETDKDGVRHIRIVGQGKLTGQTIDVPGDPSSTAFPLVAALLVEGSDVTIRNVLMNPTRTGLILTLQEMGADIEIIDPRLAGGEDVADLRVKASKLKGVVVPPERAPSMIDEYPVLAIAASFAEGETVMDGLDELRVKESDRLAAVARGLEANGVDCTEGEMSLTVRGRPGGKGLGGGTVATHLDHRIAMSFLVMGLASEKPVTVDDSTMIATSFPEFMGMMAGLGAKIAESGAE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PALC_YARLI
Sequence: MSISYTGQLPTTSPLSLTQLITSDRYQQVIENADAARARVREQLKHAKKTGATEANGDIMPVIKALEEYMPHITSIVDNEGVFRFTSQIITCWRLPFQSQSSMANKTPLHGLSFEYIMVLFTYALALATLANQYVARDKEDRWKHASAYISKARGVVDYLRQCRSFQIICNEPPASVPRDLSSATMSALSHMLCGASHMLILYKCDAETYLDGGAPSAGANSGGFSSSLLLRTAIFARDQFETASALLGEPVSKRKLVTSLVKEKSSKFSLSKKLHLRKDDGSPSLAPVSSFESNRDLSSTSSGTLDSLLSWLSRARGVAEGFVFKHMAIQAYENNQIGKAVGAAYAAILQLEDVKIPQKSALYIPVTHLKETLNRHHADYKADNDRLSFEPVPSPSELAQEWPSGRQVISAQKWTPQTSLDLGEDTSSSAPKYSGQGSYY
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator protein palC.
What is the protein family that this protein belongs to?
Belongs to the palC family.
Protein: FDHD_STAA2
Sequence: MNKDVSLGQPIVRYEDGKLFNTTDQYVTEFPLTIMVNGEEFATVICSPTNLEELVIGFLASEGAILKRDELKSVLIDDSKGFAHVELNKDLGDRFQYSTKRMIASCCGKSREFYFQNDAAIAKTSMSKITLTPIQIINMMTRLQSASHIYQETGGLHNAAISDGLTFFVHRQDIGRHNALDKLYGFCIQRHITVRDKVLIFSGRISSEILIKAAKIGVGVILSKSAPTTLAVTLANDLNITAVGFIRNGGFNIYSHPERIIDSEQ
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_BOTAB
Sequence: MPHHYILTLFGLLPVATNISTWWNFGSMLLTCLALQVLTGFFLAVHYTANINLAFSSIIHITRDVPFGWMMQNLHAIGASMFFICIYIHIARGLYYGSYLNKETWMSGITLLITLMATAFFGYVLPWGQMSFWAATVITNLLTAVPYLGTSLTTWLWGGFAINDPTLTRFFALHFILPFAIISLSSLHIILLHEEGSSNPLGTNPDIDKIPFHPYHSHKDLLLLTLMMLSLLIIVSFFPDIFNDPDNFSKANPLVTPQHIKPEWYFLFAYGILRSIPNKLGGALALVMSIMILFTIPFTHTAHLRPMTFRPFSQLMFWTLVSTFITITWAATKPVEPPFIVISQVTSTLYFTFFLLIPILGWTENKMMNTL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FGF8A_DANRE
Sequence: MRLIPSRLSYLFLHLFAFCYYAQVTIQSPPNFTQHVSEQSKVTDRVSRRLIRTYQLYSRTSGKHVQVLANKKINAMAEDGDVHAKLIVETDTFGSRVRIKGAETGFYICMNRRGKLIGKKNGLGKDCIFTEIVLENNYTALQNVKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPKGHQIAEHRPFDFINYPFNRRTKRTRYSGER
What is the function of this protein?
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity).  Required for Kupffer's vesicle ciliogenesis (PubMed:19164561).
What are the official names of this protein?
Fibroblast growth factor 8, FGF-8.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCME_CUPNH
Sequence: MTPRRRRLGLLLAALICVGIATTLVLNAFRSNLVFFFSPSQVAAHEAPVARSFRLGGLVAPGSIRREGDGMTIRFIVTDTARQVLVVYRGLLPDLFREGKGVVARGKLEADGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMAGTPQGARQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: COG8_BOVIN
Sequence: MAATATIPSSTTASATTTATAAALGEVEDEGLLASLFRDRFPEAQWRERPDVGRYLRELSGSGLERLRREPERLAEERAQLLQQTRDLAFANYKTFIRGAECTERIHRLFGDVEESLGRLLDRLPSLQQSCRNFVKEAEEISSNRRMNTLTLNRHTEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQQLRTNIQLPACLRVIGFLRQMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEHMVNESAIFHGWVLQKVSQFLQVLETDLNRGIGSRLDSLLGQCMYFGLSFSRVGADFRGQLVPVFQQVAISTFQKAIQEAVEKFQDEMNSYTLISTPAVLGSSALPAAAPVTQPGTLQPPMVLLDFPPLACFLNSILVAFNDLRLCCPVALAQEVTRALEDALDKVTKVILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGIPPTQLSKYGNLGHVNVSVVQEPLAFILPKREPVFCLDKELVPELPAPAPALPPNAPSPEPVTPVTPAVPDAGQEEVESAGPPQPDEPSAGI
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 8, COG complex subunit 8, Component of oligomeric Golgi complex 8.
What is the protein family that this protein belongs to?
Belongs to the COG8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: NDK_VEREI
Sequence: MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMVHLARPEAERFYAVHKERPFFKDLVEFMISGPVMVQVLEGENAVLKNRELMGATDPKKAQTGTIRADFADSIDANAVHGSDAAETAQAEVAFFFPGLNIYPR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_YEFV8
Sequence: MSGRKAQGKTLGVNMVRQGVRSLSNKIKQKTKQIGNRPGPSRGVQGFIFFFLFNVLTGRKITAHLKKLWRMLDPRQGLAVLKKVKRVVASLMRGLSSRKRRSYEVLTVQFLILGMLLMTGGVTLVRKSRWLLLNVTSEDLGKTFSVGTGNCTTNILEAKNWCPDSMEYNCPNLSPREEPDDIDCWCYGVENVRVAYGKCDSAGRSRRSRRAIDLPTHENHGLKTRQEKWMTGRMGERQLQKIERWLVRNPFFAVTALAIAYLVGSNMTQRVVIALLVLAVGPAYSAHCIGITDRDFIEGVHGGTWVSATLEQDKCVTVMAPDKPSLDISLETVAIDGPAEARKVCYSAVLTHVKINDKCPSTGEAHLAEENEGDHACKRTYSDRGWGNGCGLFGKGSIVACAKFTCAKSMSLFEVDQTKIQYVIRAQLHVGAKQENWNADIKTLKFDALSGSQEAEFTGYGKATLECQVQTAVDFSNSYIAEMEKESWIVDRQWAQDLTLPWQSGSGGVWREMHHLVEFEPPHAATIKVLALGNQEGSLKTALTGAMRVTKDTNGSNLYKLHGGHVSCRVKLSALTLKGTSYKMCTDKMSFVKNPTDTGHGTAVMQVKVPKGAPCRIPVMVADDLTASVNKGILVTVNPIASTNEDEVLIEVNPPFGDSYIIVGTGDSRLTYQWHKEGSSIGKLFTQTMKGAERLAVMGDAAWDFSSAGGFFTSVGKGIHMVFGSAFQGLFGGLSWITKVIMGAVLIWVGINMRNMTMSMSMILVGVIMMFLSLGVGADQGCAINFGKRELKCGDGVFIFRDSDDWLNKYSYYPEDPVKLASIVKASFEEGKCGLNSVDSLEHEMWRSRADEINAILEENEVDISVVVQDPKNIYQRGTHPFSRIRDGLQYGWKTWGKNLVFSPGRKNGSFIIDGKSRKECPFSNRVWNSLQIEEFGTGVFTTRVYMDAVFEYTMDCDGSILGAAVNGKKSAHGSPTFWMGSHEVNGTWMIHTLETLDYKECEWPLTHTIGTSVEESDMFMPRSIGGPVSSHNHIPGYKVQTNGPWMQVPLEVKREACPGTSVVVDGGCDGRGKSTRSTTDSGKIIPEWCCRSCTMPPVSFHGSDGCWYPMEIRPRKTHDNHLVRSWVTAGEVHAVPFGLVSMMIAMEVFLKKRQGPKQILVG
What is the function of this protein?
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Capsid protein C]: Virion. Host nucleus. Host cytoplasm, host perinuclear region. Host cytoplasm. SUBCELLULAR LOCATION: [Peptide pr]: Secreted. SUBCELLULAR LOCATION: [Small envelope protein M]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=ER membrane retention is mediated by the transmembrane domains. SUBCELLULAR LOCATION: [Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=ER membrane retention is mediated by the transmembrane domains. SUBCELLULAR LOCATION: [Non-structural protein 1]: Secreted. Host endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=Located in RE-derived vesicles hosting the replication complex. SUBCELLULAR LOCATION: [Non-structural protein 2A]: Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FOLCP_HALVD
Sequence: MEYHEAVNFLFDLRRFQVKPGTESIRRLLSHLGDPHEGVSFVQVAGSNGKGSTARMVDAMLRESGAHVGLYTSPHFDDVRERVRVDGRKIPKSALSAFVAEAKPYLVERAADGEPLTFFETVTALALWYFDRAGVDVAVLEVGMGGELDATSAVDPVASAVTNVSLEHTAVLGDTVAEIAKTKAAVAPADAPLVTGTTGEALSVIREEAGDVLTVGDADADSDADVRVSYGGRVNHQEAAVTVETDAETLDVRIPLLGAYQARNAGIAVSLARQVRPDIDAEAIHRGLRNAHWPGRFEVMGTEPTVVLDGAHNPDACAQVATVLDEFDYDDLHLVYGAMHDKDHGEMVGALPEVASVVTCKADISRGEDPEILSSVFERLNGPAVETGGAVAAALDRARARADPDDCVLVVGSLYVVAEARTTWTRAVVPKTHRTLDDARRTLDRANVADAAERSERARRAVNRTVHTRVQRRQARVLREELLSVGGDCAVSGHEFGGELVDVVLTGTLDQFERLTAALEDPPYALAGVAAEIRETLDIEAADAGEDDERGAGDASDAGHDDYPWNDGTAVMGILNVTPNSFHDGGEFYDIDDAVEQARAMVDAGVDIIDVGGESTRPGADEVPVDEEIRRVAPVIEAIADLDVLVSVDTRKAAVGAAALDAGADILNDVTGLEDPEMRFLAAERGAPVIVMHSIDAPVDPSREVDYDDVVEDVIDELTELVLLAEKAGIPRRNLIVDPGLGFGKSKAENFELLGRTDEFAALGCPILVGHSHKSMFSLVGEEPGDNLAATVAGTAIAADRGADIVRVHDVPENVAAVNVALASRDPNRFEADAERED
What is the function of this protein?
Can complement an H. volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB.
What are the official names of this protein?
Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DHPS family.
Protein: RS8_RUBXD
Sequence: MAVNDPIADMLTRIRNAVMAKHERVEIPHSKMKVEIARILKEEGYVRDYAVRGSGPQQRIVIELKYGPDGERAITGLRRMSRPGRRVYRKQKDIPRVLDGLGVAILSTSQGILTDHEARRKGVGGEVLCFVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HIS3_AROAE
Sequence: MSRPNSVRWLNEVQWDDQGLVPVIAQEAASGDVLMFAWMNREALQRTAETGEAIYWSRSRRRLWHKGEESGHIQKVLEIRLDCDSDVVLLKIEQIGGIACHTGRHSCFFQRYLADGSWETVDPVVKDPKDIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPP3_PONAB
Sequence: MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFASKAPVEEGFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAILEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSRAS
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala.  Also shows low activity towards peptides with Ala or Ser at the P1 position.  Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity.  May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
What are the official names of this protein?
Xaa-Pro aminopeptidase 3, X-Pro aminopeptidase 3, Aminopeptidase P3, APP3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation.
Protein: UBIE_BURP6
Sequence: MSKTHFGFETVEENEKAKKVAGVFHSVASNYDLMNDLMSAGLHRAWKAFTIAQANVRPGGKVLDIAAGTGDLTKAFAKAAGPTGEVWHTDINESMLRVGRDRLLDKGVVTPSLLCDAEKLPFPDNYFDVVTVAFGLRNMTHKDSALAEMRRVAKPGGRVMVLEFSKVWEPLKKAYDVYSFKVLPWLGDKFAKDADSYRYLAESIRMHPDQETLKTMMEQAGLDAVKYYNLSGGVVALHVGTKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: SECY_LACLC
Sequence: MFFKTLKEAFKVKDVRARILFTIFILFVFRLGAHITAPGVNVQNLQQVADLPFLSMMNLVSGNAMQNYSLFAMGVSPYITASIIVQLLQMDILPKFVEWSKQGEIGRRKLNQATRYITLVLAMAQSIGITAGFQAMSSLNIVQNPNWQSYLMIGVLLTTGSMVVTWMGEQINEKGFGSGVSVIIFAGIVSGIPSAIKSVYDEKFLNVRPSEIPMSWIFVIGLILSAIVIIYVTTFVQQAERKVPIQYTKLTQGAPTSSYLPLRVNPAGVIPVIFAGSITTAPATILQFLQRSQGSNVGWLSTLQNALSYTTWTGMLFYALLIVLFTFFYSFVQVNPEKMAENLQKQGSYIPSVRPGKGTEKYVSRLLMRLATVGSLFLGLISIIPIAAQNVWGLPKIVALGGTSLLILIQVAIQAVKQLEGYLLKRKYAGFMDNPLETK
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIG_CLOB8
Sequence: MKAKVEKIETNVIKLEIRVEAEKFDAALTKAYNKNKGRYNIPGFRKGKVPMAMVKKFYGVEVFYDDAVNFAIDESYPEALNAENIKPVDYPQVDIVELGEGKELVYTATVTTYPEVELGEYKGLDIKKPIYEVEDTEIDKQIKEMQEKNARIEVKTEGNIAKGDIAVIDFKGYIDGVAFEGGEGSDYSLEIGSGTFIDNFEEQLIGLAVGDKKEVNVTFPEAYGKEELNGKPAMFEVEIKSIKVKELPELDDEFAKDVSAVDTFAELKENLKKTLEKNNDEKAEREFEEAVITAVIENSKMDIPEVMVNKEIDAMMQDLEGRLKYQGLSLEQYMEFTGNTTEKMRDFMKENAERKVKADLVLEAIAKTEEIKATEEELNARALELGKIYGPKDPEKMAKILVKSQRNMIEKDIILENTLKFLKENCK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PUR8_BUCBP
Sequence: MIASPLFAISPIDGRYSSKVIKLRNIFSEYAFLKFRVTIELLWLKKISLLQEFKIVYNKDVLNCLDRIIDNFSKKDALEIKILEKKTNHDVKSIEYFLQKKIFKCLGNHDILGLVHFGCTSEDINNLAYALMLKVSRRDIILPLWNKIIFEIKKIALLHHNVPMLSRTHGQPATPSTIGKELINFAYRLERQLKQFKNIEILGKINGSTGNYNALHFSHSSVDWHKISQEFVTSLGLFWNPYTTQIEPHDFISEFFSCLARVNTILINFNRDIWGYISLQYFNQTPKLDEIGSSVMPHKINPIDFENSEGNLGLSNAIISHLIEKLPISRWQRDLSDSTVLRNVGTVIAYSIIAYDSIILGLKKLKVNTSRLLQDLNHHWEILAEPIQTVMRKYGINDTYNELKNITRGKRVTSDIILKYVNSLKIPRNEKEKLLQLTPENYLGLSSKLVKIFNNSSELK
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: COX3_SYNY3
Sequence: MTSPMGPTARDFWQNSRNSATIQRLIVSPMQTTALSSDLNSTYTPGEAHGHHGHPDLRMFGVVLFLVAESAIFLGLFTAYLIYRSVMPAWPPEGTPELELLLPGVNSIILISSSFVMHKGQAAIRNNDNAGLQKWFGITAAMGIIFLAGQMYEYFHLEMGLTTNLFASCFYVLTGFHGLHVTFGLLLILSVLWRSRQPGHYSRTSHFGVEAAELYWHFVDVVWIVLFILVYLL
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome aa3 subunit 3, Cytochrome c oxidase polypeptide III, Oxidase aa(3) subunit 3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAND_ACIET
Sequence: MYRTLLKSKIHRVKTTHCELHYEGSCAIDEDLLEAANICENEQVHIWNVDNGERFVTYAIKGQRGSGMISVNGSAARRACVGDLLIIAAFAQVAEADVAAHQPQLVFVNDQNRQVELRHHVPTQAL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDH5_ARATH
Sequence: MGTLGRAIHTVGNRIRGTAQAQARVGSLLQGSHHIEKHLSRHRTLITVAPNASVIGDVQINKGSFISYASVSRDLQYPRAMGMGQVRRFSEDVSHMPEMEDSDVLNAFKDLMAADWAELPSAVVKDAKTAISKNTDDKAGQEALKNVFRAAEAVEEFGGILTSIKMEIDDSIGMSGEGVKPLPNDITDALRTAYQRYAEYLDSFEPEEVYLKKKVEMELGTKMIHLKMRCSGLGSEWGKVTVLGTSGLSGSYVEQRA
What are the official names of this protein?
Succinate dehydrogenase subunit 5, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.