PharMolix/UniProtQA huggingface dataset:
Protein: PRX4_PENRW
Sequence: MIPRWQPASIALLLHLDTLRCHHVSVRPPRATMTSLSIKEEDIPRLDGKVVVISGGASGIGLAAANIFARAGAKIFLFDRNPPDSGEAPENSTFIKADVTSWAELKAAFAQAGHVDIAVANAGVSEEQPYFEDTFDEQGELKEPGFAVVDVNFKGTVMFTKLAVSYMRKQGKGGSVVITASATGYAPEQNLPVYSAIKSGLVGLVRSLRSTLPRFDISINAVAPAATITKLLPMDIAGPLMAAGLPVSSAHMVGLAVVYSAVARQPRMVETYGKENMLDLESKWNGRTILTLGEHYTELEEKLADLRPVWFGWRNTDLTKKQQATADFR
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase prx9 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699) (By similarity).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase prx11 (By similarity).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:24239699).  The cytochrome P450 monooxygenase prx8 also plays a role in this step (By similarity).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:24239699).
What are the official names of this protein?
Short-chain dehydrogenase/reductase prx4, PR-toxin biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TAL_METFK
Sequence: MANLFDQLKEFTTIVADTGDVEAIKSVKPYDATTNPSLLLKASTIPQYAPLIDEAIAYAKSQSGDKAQQIEDAADKLAVLIGLEILKHIPGKISTEVDARLSFDTEAMVQKGRKLIKLYEDAGIAKDRVLIKLASTWEGIKAGEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKAKTGETYTAETDPGVQSVRKIYAYYKEHGYKTVVMGASFRNTGEIIALAGCDRLTVSPNLLEELKATEGKLERVLVDNGVTKQRPPLLTEKEFRFDLNEDAMATEKLAEGIRGFVVDQNKLEKALAEKL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEX1_PARBP
Sequence: MGFSGSRAWSKWLTICLAITHPFSVTAKSAADYYVHSLPGQPEGPLLKMHAGHIEISPETSGNLFFWHFENRHIADKPRTVVWLNGGPGCSSEDGALMEIGPYRLIDKETLNYTEGSWDEFANLLFVDQPVGTGFSYGSTEHYVHELDEMASQFVTFLEKWFEIFPHYEPDDLYFAGESYAGQYIPYIARAVLDRNKKQDVQANNRIWNLKGLLIGNGWISPQHQYPAYLPYVYQEGVVQAGTQEANLIEAKAAKCMKELNVEDTTGTVHIPDCEDILQAILDYTHKGKRCINMYDIRLTDDYSACGMNWPPDLRDIQPYLRRKDVVKALHINEEKQTGWTECAGAVGSSLKARNSKPAVELLPGLLEEGLPILLFSGQKDLICNHVGTEDMIKNMKWSGGTGFELSPGVWAPRQDWTFEGEPAGIYQQARNLTYVLFYNASHMVPFDYPRRSRDMLDKFLGVDITHIGGDPADSRIDGEKGPTTSVGAHPNSTAAAEREKEKLNTAAWKAYYKSGEVALVIVAIAAFAWGIFIWRSRRKHQSSGYRSIYPMLGLNSTGSLGQISHKHSRRNGDIEAADFDETELDDQPSQAFLSRSSRDGDAYAVGEESSDEEDGASDGQQPMFDQSRGEEGRS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: AROC_CAMLR
Sequence: MNSFGIRFKFTSFGESHGQAIGCVIDGMPAGVKFDFDFLQEMLDKRKPGQNKFSTPRKEEDKAQVLSGVFEGYTTGTPISVLVYNENTRSKDYEKDVFRPAHADFTYYHKYGIRDYRGGGRASARESIARVAAGALAQMLLKEFDIEIMSGVFGVGSIDSKLSNDEFDFNCAKNSEVYALDKNLEQSFKDEILKAKKAKDSIGARVFTRVKNPIKGLGEPLYDKLDSKLAHAIMGVNAVKAIEIGSGIQSSYMYGSQNNDELKDGVFLSNHSGGILGGISNGGFIDIKTYFKPTPSIFLPQQTQNIQGENIIRELKGRHDPCVGIRGSIVVNAMVAICMADALLLNASSNLQNLQRVYGKNK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ATG5_SCHPO
Sequence: MNVDNNKGNIPELLWNGTISVRIDYEGNSLAYLANVPRQSYFAQILPNVQRLLAPSIPLSECWLDYNGVPLKWHWPVGLLFDLLTVFDPDTPRAPVLWRIQLRSGLFPTTKILQMETMDTFRTYFFNCLKESDYVRNGSSSGIIALSKAETDTYWNAILNHDYYDFRPIAIKILFSKSKFIPLKIYLGANAPIIQTSAPLGSSLGEFLNKRLPDLFPSCDKFLIVKPVIHGITIFLQSVLDELNRDFCYIDGFLHIVLMKV
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).  Has a role in meiosis and sporulation.
What are the official names of this protein?
Autophagy protein 5, Meiotically up-regulated gene 77 protein.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: DNAK_SULNB
Sequence: MGKVLGIDLGTTNSAMAVYTNGEAAIIANKEGKNTTPSIVAFTDKGEVLVGESAKRQAVTNPEKTIYSIKRIMGLMCEEEKANEAKERLPYHIIDRNGACAIEVAGKTYTPQEISAKVLMKMKEDAEAYLGETVTDAVITVPAYFNDAQRKATKEAGTIAGLNVLRIINEPTSAALAYGLDKKEAEQIVVYDLGGGTFDVTALETGDGVVEVLATGGDAFLGGDDFDNRIIDYVADEFKSESGIDIKADVMALQRVKDAAEAAKKELSSATETEINLPFITADASGPKHLVTKITRAKFESLIGDLVAKTIKTIEAVLKDAGLSKNDVKEVVMVGGSTRVPLVQEEVKKFFNKELNKSVNPDEVVALGAAIQGGVLAGDVKDVLLLDVTPLSLGIETLGGVMTKVIEKGTTIPAKKSQIFSTAEDNQPAVSIHVLQGEREFAKDNKSLGMFELRDIPAAPRGVPQIEVTFDIDANGILTVSAVDKGTGKSQEIKITGSSGLSDEEIEKMVQDAEAHKAEDEKRKAVVEAKNQADALIHQTKKSLDDLGENFDANEKAGIEAAIADLETVLKDDNATKEQIDEKVKALTEKSHKLAEAAYAKEQGGQQGAADAGKKADDDDVIDAEVE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FIBA_CERNI
Sequence: ADGSDPASSEFLAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_ALCBS
Sequence: MSEYSIFTSESVSEGHPDKMADQISDAILDAIIKDDPHARVAVETMVKTGMAVVAGEVRTNTYVELEDIVRQVILDIGYDSSEKGFDGASCAVLNGIGKQSADIAIGVDEAEEKEMGAGDQGLMFGFATDETDTLMPAPVYYSHRLVERQAKLRKNSTLPWLRPDAKSQVTLRYDNGKPVAVDAVVLSTQHSPDIKLADLREAVMEEIIKPVLPEEWLHKDTLYHVNPTGIFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLASKCEIQVSYAIGVAEPTSISVNTFGTGKISDSAIVDLVREHFDLRPRGIIEMLDLRKPIYRPTASYGHFGREGFSWEKTDKTEALKAAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTP25_AJEDR
Sequence: MVAPRGRDAEDEVELIDELSSGSDDDDEEDKKTSKPYNTLLQLFNAGQDTNGPARKRRKVEHSSKKTEVQIKEPEELDDEADLSESEIEDDEEDEDAEGIAVDEGEAEDSGDEDDATDPFETHFSNVDSSLLLQQINVISTKGWKTHKNELPGKFRLVLSHPDTGGDAVQLPPPAHGLQSLKLKQKLANHAGDHIAKFESLTSGLVPYIFGYQDLLFGARTLSNSAKFRDLYCLHVLNHILKTRDRVLKNNSRSQKEPDQDLELRDQGFTRPKVLIILPTRQACVRVVESITKLYHAEQQENKSRFYDTFSAADDKSWEDKPDDFRELFGGNDDDMFRLGLKFTRKTIKYFSQFYNSDIILASPLGLRMVMDKEDGKKQDFDFLSSIEVAVVDQADALLMQNWEHIEYVFSHLNLQPKESHGCDFSRVRNWYLDGQAKYVRQTLVFSSFITPEINALFSSQMHNTAGKVKVTPTYEGAILDIPLPVPVKQTFSRFNSTSPVKDPDDRFKYFTSAVLSSLVRSSTGSGGKPHASGTLIFIPSYLDFVRVRNYLATSSQTENLSFGAISEYTSVRDVARARTHFFSGRHSALLYTERTHHFRRYQIRGVKRVIMYGVPENPVFWGEIVGFLGLDPAGTAEAAEGGVRALFSKWDALKMERIVGTKRLGNMLMEKGGDTFSFV
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL24_ACAM1
Sequence: MAKKKSTAKRYKMHVKKGDTVQVIAGKDKAKVGEVIDVLPKLSQVVVEGVNMKTKHVKPRSESESGQISTVEFPIHSSNVMLYSNKENVASRVCYTFDDSGRKVRMLKKTGEIID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RBS_OLILU
Sequence: MRLTQGAFSYLPDLTDAQIIKQIDYCLSRGWSVGVEWTDDPHPRNAYWELWGLPLFDVKDSSAILYEVNECRRLNPEGYIKLVAFNAARGTESSASAFIVQRPKSEPGFYLERTEAEGRMIRYTIHSYAVARNPEGSRY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COG6_CHAGB
Sequence: MSSSSGPLSPQSTTATSSLAAKAANPLSSKVTTVLSSSYADTEFREALALLDERGVQNTAETRRQLRLDLQKEVIDSNGEIIDEFAKVAEQLRRIGTTIGRLNETFNEMKTQIGSAQKTTSSTLIEASQLMIQRRQVEQKQALLGAFNTNFVLSEDETAALTLTSEPVDDLFFAVLAKAKRISKDCEILLGFENQTLGLEIMEQTSKNLNLGFQKLYKWVQREFKTLNLENPQIGSSIRHALRVLAERPSLFQNCLDFLAEAREHVLSNSFHTALTGSSPSGIEDQSVKPIELVAHDTLRYVGDMLAWAHSAAVGEREALEGLFIGEGDEIAKGIQAGRDNEIWRLVAEDGEVSDTFDAVETLNELVDRDLSGAARLLRQRVEQVIQTNEETILAYKLANLLNFYKSTFSRLLSVGSALVETLGALESEALRQFRSLARDHVAAIQGDFQHTPADLRPPEFLLGALEQLAAIMKTYETSFTSSSDREEEFEPVLAEAFDPFISGSANMAKPLRAPSNSIFLINCLLTAERSLSRFDFTQRRAARLQAQIQEERARLVETQYRFFRGESGLDSLIVQLEPLGESKEDIQKALLLESLQSPALSQASQKLDDFLPSALMDAMENLKNLQDSRLVQSITEEAAEKFCVDFEHVEEMLILVDEATEQKQNEQDDIQGPRTLFPRTSGEIRVLLS
What is the function of this protein?
Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking.  COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: CM3B_CONCN
Sequence: QGCCGEPNLCFTRWCRNNARCCRQQ
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  This synthetic toxin blocks slightly but irreversibly tetrodotoxin-resistant VGSCs.
What are the official names of this protein?
Mu-conotoxin CnIIIB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: K1143_HUMAN
Sequence: MSKRNQVSYVRPAEPAFLARFKERVGYREGPTVETKRIQPQPPDEDGDHSDKEDEQPQVVVLKKGDLSVEEVMKIKAEIKAAKADEEPTPADGRIIYRKPVKHPSDEKYSGLTASSKKKKPNEDEVNQDSVKKNSQKQIKNSSLLSFDNEDENE
What are the official names of this protein?
Uncharacterized protein KIAA1143.
Protein: RHO_PSEFC
Sequence: MNLTELKQKPITDLLQLAEEMGIENMARSRKQDVIFSLLKKHAKSGEEISGDGVLEILQDGFGFLRSADASYLAGPDDIYVSPSQIRRFNLRTGDTIVGKIRPPKEGERYFALLKVDTINFDRPENAKNKILFENLTPLFPTVRMKMEAGNGSTEDLTGRVIDLCAPIGKGQRGLIVAPPKAGKTIMLQNIAANIARNNPEVHLIVLLIDERPEEVTEMQRTVRGEVVASTFDEPPTRHVQVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVIPSSGKVLTGGVDAHALEKPKRFFGAARNIEEGGSLTIIATALVETGSKMDEVIYEEFKGTGNMELPLDRRIAEKRVFPAININRSGTRREELLTADDELQRMWILRKLLHPMDEVAAIEFLIDKLKTTKTNDEFFLSMKRK
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: KRI1_YEAST
Sequence: MPRKKSAAKRAREQAKKEAAVPATDTATIKTSETSATTVKPAIEASKSYVPSEDEEEDEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTDKLLDPKVKFFEDPESAAAKLANREGKHKPIYLKDYHRMNILSGDALKEDDEEYEHATVDGKQSFVSQQREEKTQLLNEIKSAFSDEENEESSGDEDDGFLKKKEPSTKKEGKNLPDPTVNEENFLEEFVNQQAWIPKKGDKVISLDLNNNEEDDEEFEDAAEKFENAYNFRYEDPNAAEIISYARSQATLRRSDDSSRRRKREEKRKIKEQIKAEKETALQKKKTKKLNKLTDILEQLTKEYGAEINADMVKKITDTLLKNDFKEEEWDNVVAELFNEEFYQQEGKPTWNEDDEIMGDFYADADGDDQTEEGEVEKEQKEEDEEEGPKRKKSKKEEKLQKKKEKRKVNELVENALEQNKLALIEEVEKEEEERKSRSRTKEEQDLKFRYREVSPESFGLTAREIFAADDTDLNEFIGLKKFAPYRSKELRAKDKRKVMKARRLREWRKKTFKNENGLAPVEAEAGEKDEDTILIPVEKASKSKHKRGHSHKHKGHQKK
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA.
What are the official names of this protein?
Protein KRI1, KRR1-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the KRI1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TRMB_STRCO
Sequence: MSDSHHTPEAASASLRHVRAKGEPRFPDGPKADPAGSHFERRIRSFQPRRSRVTAGQADALQRLWPLWGLDIDGRRVVDLAELFGNARPVVLEIGFGMGETTARMAAADPDTNILAADVHTPGQGNLLGLAERQELPNIRVANGDAIILLREMLAPGSLAGLRVYFPDPWPKKRHHKRRLIQPEFLTLAATRLAPGAVVHCATDWEPYAEQMLDVLTAHPDFENTVPGGGFAPRPEHRPLTRFEGQGLDKGHVVNDLLFRRVQHKEPPPNG
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: LCTL_HUMAN
Sequence: MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVTEIVVPTVCSLCVLITAVLLMLLLRRQS
What is the function of this protein?
Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
What are the official names of this protein?
Lactase-like protein, Klotho/lactase-phlorizin hydrolase-related protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: VF407_ASFM2
Sequence: MEDTTFLEGANLAGITTLMNNLHINEQANLEELEKQVMGKQQSFPTDHFDEELNGLAKSLGINFNDPEFSLDSAHSVISKKPSGGGSIRGDLCRHSMRGDKISHEKIHSGIRRDSVCSDSVCSDSIRSGSVRGSSMHDGSTCDGSACDGSVRSGRTRRGPARSSSSRHDRIHGYSLSTHRKKYAESEASQKTVISKRDRKNHYAESEYSEKSIKPSTKQVDRLINHLRSNGDPNSFYKKEHDYDRKTKLVKLERINMLLTYLTNEQISTDGIKIPTIDSSMQEIDDAIEMLTLRNVGIRYSSIAEEILIGLARGLEIVFDGTREIPFLNYRPDYTGLHNTFMIKLFKMRYETSQVVGNLVQNMSPLSKICLELGPSLLLYPALIRTKHKASEDLYNLLQKGPEDPFTAYNEIHETLKKNNK
What are the official names of this protein?
Uncharacterized protein B407L, pB407L, Protein L09BBL.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B407L family.
Protein: GPD2_ZYGRO
Sequence: MAATDRLNQTSDILSHSMKKTDTSMSIVTAENPYKVAVVGSGNWGTTIAKVVAENTKEKPELFQGRVDMWVFEEQIDGTPLTQIINTKHQNVKYLPNIDLPGNLVANPDLISTTKDADVIVFNVPHQFLGRIVSQMKGQIKPDARAISCLKGFEVGPKGVQLLSDYVTQELGIQCGALSGANLAPEVAKEHWSETTVAYQVPDDFKGEGKDIDHRVLKQLFHRPYFHVNVIDDVAGISIAGALKNVVALGCGFVTGLGWGNNAAAAIQRVGLGEIIKFGRMFFPESKVETYYQESAGVADLITTCSGGRNVRVATEMAKTGKSGEQVEKDILNGQSAQGLITAKEVHQWLESSGHTEEYPLFEAVYQITYENVPMKELPSMIEELDIVE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, ZrGPD2.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUB_ECOHS
Sequence: MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGVSGSADLSQFPIALVQRVEYIRGPRSAVYGSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQAQTDNDGFLSKTLYGALEHNFTDAWSGFVRGYGYDNRTNYDAYYSPGSPLLDTRKLYSQSWDAGLRYNGELIKSQLITSYSHSKDYNYDPHFGRYDSSATLDEMKQYTVQWANNVIVGHGSIGAGVDWQKQTTTPGTGYVENGYDQRNTGIYLTGLQQVGDFTFEGAARSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQLYGFYGNPNLDPEKSKQWEGAFEGLTAGVNWRISGYRNDVSDLIDYDDHTLKYYNEGKARIKGVEATANFDTGPLTHTVSYDYVDARNAITDTPLLRRAKQQVKYQLDWQLYDFDWGITYQYLGTRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: CLPC_STAAS
Sequence: MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDHVGTLHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGNPEMSNKNAQASKSNNTPTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKDKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIQQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPVQVDEPSVVDTVAILKGLRDRYEAHHRINISDEAIEAAVKLSNRYVSDRFLPDKAIDLIDEASSKVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEAKNEWKNAQNGMSTSLSEEDIAEVIAGWTGIPLTKINETESEKLLSLEDTLHERVIGQKDAVNSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGDDDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRTVDFRNTIIIMTSNVGAQELQDQRFAGFGGSSDGQDYETIRKTMLKELKNSFRPEFLNRVDDIIVFHKLTKEELKEIVTMMVNKLTNRLSEQNINIIVTDKAKDKIAEEGYDPEYGARPLIRAIQKTIEDNLSELILDGNQIEGKKVTVDHDGKEFKYDIAEQTSETKTPSQA
What is the function of this protein?
Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: GLTJ_ECOLI
Sequence: MSIDWNWGIFLQQAPFGNTTYLGWIWSGFQVTIALSICAWIIAFLVGSFFGILRTVPNRFLSGLGTLYVELFRNVPLIVQFFTWYLVIPELLPEKIGMWFKAELDPNIQFFLSSMLCLGLFTAARVCEQVRAAIQSLPRGQKNAALAMGLTLPQAYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMTLVERKVRLPGNMGGK
What is the function of this protein?
(Microbial infection) Probably transports the toxic C-terminal region of CdiA from P. luminescens strain TTO1 across the inner membrane to the cytoplasm, where CdiA has a toxic effect.  Toxin transport is strain-specific, mutations in this gene do not confer resistance to several other tested CdiA toxins.
What are the official names of this protein?
Glutamate/aspartate import permease protein GltJ.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UXAC_BACFN
Sequence: MKNFMDKNFLLQTETAQELYHNHAAKMPIIDYHCHLNPQMVADDYRFKSLTEIWLGGDHYKWRAMRSNGVDECFCTGKETSDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKVLNPKTAREIYDECNEKLSSQEYSARGMMRRYHVETVCTTDDPIDSLEYHIRTRESGFEIKMLPTWRPDKVMAVEVPSDFRTYIEKLSEISEITISDYNDMILALRKRHDYFAEQGCKLSDHGIEEFYAEDYTEGEIKTIFNKIYGGSELTKEEVLKFKSAMLIVLGEMDWEKGWTQQFHYGAIRNNNSRMFKQLGPDTGFDSIGEFATAKAMSKFLDRLNSKGKLTKTILYNLNPCANEVIATMIGNFQDGSIPGKIQFGSGWWFLDQKDGMERQLNALSLLGLLSRFVGMLTDSRSFLSYPRHEYFRRTLCNLLGCDVENGEIPLSEMERVCQMVEDISYFNAKNFFHF
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.