PharMolix/UniProtQA huggingface dataset:
Protein: DLTC_BACC7
Sequence: MAEFKEQVLDILEEVCENDIVKENLDVQLFEEGILDSFAVVSLLVEFQERLDIEVSISDFDRDEWATPNMVIKKLEEIR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_LACSA
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSSAL
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEU3_HAEI8
Sequence: MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEAAMKRNKKVTSVDKANVLQSSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMGTLITQAI
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_SALDC
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPILPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_SALG2
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKTRLGANPVPLQLAIGAEEGFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLANEWHQNLIESAAEASEELMEKYLGGEELTEEEIKQALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKTARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPENPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPRS_MOUSE
Sequence: MEGSNGSPRMSTEQENTEMHLIECMLKHFKIQKVAISNAIRSTFPFLESLRDREFITGKMYEDLLDSCRSLVPVDKVIYRALEELEKKFDMTVLCKLFNEVNMEKYPDLNLLRRSFECGAKPALKTMNSSSEHCNISDWLRLEATLKASVYMVAFSITTSLTIVIIAIVSQSLQLRKECFNPFVYGLHNRDLQSKLYPWLCCQKKLLP
What are the official names of this protein?
Component of Sp100-rs.
Protein: PETN_PROM3
Sequence: MLFTLAWASLAAVFSFSIAMVVWGRNGDGSLNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: DYRK2_DROME
Sequence: MLDRCEMPIQLDNEKLRRDVRLSGSRLDLPQLCNGSRRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTATIATTTHHHHHHGGQQQQQSSSGASTMAMSHSQSTGDVSDRAIFGRA
What is the function of this protein?
In vitro; can phosphorylate exogenous substrates on Ser and Thr residues.  May have a physiological role in development being involved in cellular growth and differentiation.
What are the official names of this protein?
Dual specificity tyrosine-phosphorylation-regulated kinase 2, Protein smell impaired at 35A, dDyrk2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_CLAM3
Sequence: MAAIEAVNAREILDSRGNPTVEVEVLLEDGTFTRAAVPSGASTGAFEAYELRDGDAGRYLGKGVQKAVAAVVDEIGPAIQDLDAADQRIIDATMIELDGTENKSRLGANALLGVSLAVAKAAADSAELPLYRYLGGPNAHTLPVPMLNVINGGSHADTNVDIQEFMLLPVGASTFSEGLRWGVETYHALKSLLKKKGLSTGLGDEGGFAPNLDSNRAALDLLMEAIDAAGFTAGKQIALGLDVASSEFYSDGAYTFEGQKVDAAHLTAYFADLVASYPLITIEDPLDEDDWAGYDHFTAELGAKVQIVGDDLFVTNPKRLADGITRGVANSILVKVNQIGTLTETLDAVSLAQRSGYTTVLSHRSGETEDTTIADLAVAVDAGQIKTGAPARSERVAKYNQLLRIEQDLGAAAVYAGRSAFPRFQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DISA_CLOB1
Sequence: MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: DUT_BURCJ
Sequence: MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDEFTESDRGEGGFGSTGRH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ARFF_DICDI
Sequence: MLSEFFNNITSFFVNIFSLFEGKRNIRILMIGLDGAGKSTLLYKLKFGDVIRTIPTIGFNVEIIEYKNLSMNVWDIGGQNNIRALWRQYDQRTDVFIFVVDSTDRERFDEVKQEIKNIIEQNKNESSNASLLIFANKQDMLNPITPAELVNSLDLNSLTNKKWHVQPCSAVRGDGIYEGFDWIVSNSSGK
What is the function of this protein?
GTP-binding protein that may be involved in protein trafficking.  May modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
What are the official names of this protein?
ADP-ribosylation factor F.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: CITG_ECOSM
Sequence: MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLNGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMATNGDTNVASRGGEGGLRWLQREAQTLLNNGGIRTPADLDYLRQFDRECIERNLSPGGSADLLIITWFLAQI
What is the function of this protein?
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
What are the official names of this protein?
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: K1586_HUMAN
Sequence: MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKESTNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMKMKIFKNIIEENAKICIIIDEASTVSKKTTLVIYLQCTIQSAPAPVMLFVALKELVSTIAECIVNTLLTTLNDCGFTNEYLKANLIAFCSDGANTILGRKSGVATKLLENFPEIIIWNCLNHRLQLSLDDSISEIKQINHLKIFIDKIYSIYHQPNKNQTKLLGTVAKELETEIIKIGRVMGPRWAACSLQAATAVWHAYPILYMHFSHSYSGLAKRLANINFLQDLALMIDILEEFSVLSTALQSRSTNIKKAQKLIKRTIRALENLKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNALPRSILLDNIIQHMNLRLLSDRNHEDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCKILKYEVDLNDFREFVNNNIKSNNVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTRVRNSLTIDHVSDLMTINLLGKELADWDATPFVKSWSNCNHRLATDTRVRQKSTKVFHENQLAIWNLK
What is the function of this protein?
E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).
What are the official names of this protein?
E3 SUMO-protein ligase KIAA1586, E3 SUMO-protein transferase KIAA1586.
Protein: COAD_CLOP1
Sequence: MRVGVYPGSFDPITKGHLDLIERAASKFDKVIVAVLININKKGMFSIEERVNLIEKCVAKYNNVEVKSFNGLLIDFVRKEKADVIIKGLRSVTDFEYEFQMALMNRELANEVETVFMVTSPNYSYISSSAIKQVASFNGEIKNFVPKEIVEDLEERISSLRGEG
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QVR_DROER
Sequence: MWTQRNAVGNWLLVLTAVIGFLTFIWIPQTSAECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR
What is the function of this protein?
Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation.  Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability (By similarity).
What are the official names of this protein?
Protein quiver, Protein sleepless.
What is the protein family that this protein belongs to?
Belongs to the quiver family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: KCC2_SCHPO
Sequence: MSILAGFKNLLKHSKSSKGRSNASKSVDVSVNRDVAAYTELAAKNVNAGGDEEIRVANYPGLEKYQLIENLGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNVVNLFDFVETEDFYHLVMELAEGGELFHQIVNFTYFSENLARHIIIQVAEAVKHLHDVCGIVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKLDEGMFLEGIGAGGIGRILIADFGFSKVVWNSKTATPCGTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGFPPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQFFQHPWIKGESKMPENFTYKPKLHGTPGGPKLSLPRSLVSKGEIDIPTTPIKSATHPLLSSYSEPKTPGVSSVHEAMGVAYDIRRLNHLGFSPEQLSKKSMNTGSIKELILDEETTTDDDDYIISSFPLNDTLGSEGKDPFSLNLKESSLYSRRSAKRVN
What is the function of this protein?
Has a role in the regulation of G2/M transition during the mitotic cell cycle.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II, CAM kinase II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Barrier septum. Forespore membrane. Ascus epiplasm.
Protein: MSRB_YERPG
Sequence: MAKELNPTENIEKLSDIQRYVTQERGTEAPFTGKLLHNKRDGVYQCLCCHQPLFISESKFDSGCGWPSFYQPIDADSIRYIDDYSHNMHRIEIRCGNCDAHLGHVFPDGPQPTGERYCINSASLNFVDDQNGEQTAG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: BR2_PELPV
Sequence: GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
What is the function of this protein?
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity.
What are the official names of this protein?
Brevinin-2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL24_BACC2
Sequence: MHVKKGDKVQVITGKDKGKQGVILVAFPKQNRVIVEGVNIVKKHSKPSQLNPQGGIITKEAPIHVSNVMILDPKTGEPTRVGFKVEDGKKVRIAKKSGELLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: BDNF_CHISR
Sequence: SCMKAAPMKEVSIRGQGSLAYPGLRTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQPSKENKDADLYSTRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSFVRALTMDNKKRIGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS2_MYCAP
Sequence: MENENLKVEQATTAENNMAEKADDSKASKEVKPTIVSREKLLEAGTYFGHKKSMWNPKMKEFLYPQSKRGMHMINTNVTLQRLEFAYNILNKFVAKNPRTTFIFVGTKKQAKDTIKDNALRTGSFYVSERWLGGTLTNASTIFKRVKVMEELEAQAAKKFQGYTKKEGLIKQKELDKLHKNLDGIRKMQSLPSFMIVADPNVDAIAVKEARSKGVKVIGILDSNSNPDAVDFGIPANDDSAKSITLIMTILADAIATARGGKAKFAYQGDDKVILPEFKTDKTLNPRFMNQRRSFEQNSAEGVKTVEKTTTSTEVAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: KU70_CRYNJ
Sequence: MSSYYNKGDAPSWEALDQDGLDDVIDTSEPSAVAEDPGNYQPGNYVFQTLRTINAEEMKRLVKLMQTAKEQYEAQDDDETVETTEPEILRKTFPPIEESHEMNIANVIQTCNFLFRDGGTQLRGNKRVFWITDNDMPPGMNNRQPARTSYGDLTTYGVTAETFFIDRPDHRFNPNIFWNDILDREAIDYNDDQPDPEGLSSLADLMKDLVIKTSPKRTHFHVPLKLGKDGEIVIGVSGCSMVSEQGKGASRYVKMRGQVVEEVQSKTEYTSAKSLNSGQWGSNPIKVLGFQAASQLRFQDNLKHPFFIYPNEEEYTGSTRTFAALLNSCLKYNRHALALCRLRSNHVPEFCVLIPQEEKTSSNGQEYPPGFHLIILPYKDSIRPPPKKVAEFLQSPPIATDEQINAMKAVIKRTRFKAAAYRPEIYPNPSLAYHYDQLQALAFEEDWDPEDPAKQALDKTMPLYGGMHSRAGEFMEEFNKEIENDERAVEKLAAPTKRGKAEKETTVNEWDLRNIPDMWKKGTLSQLSILARLRLRRRPFTGQNQKGGYHRRRIRTSFHK
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit Ku70.
What is the protein family that this protein belongs to?
Belongs to the ku70 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: DAPE_CAMHC
Sequence: MRHFDSMEILNELLKFQSITPDDDGAFNYISMILNDFEEINIDKNGVKNVIFRKTFGPGVHICFAGHIDVVKPGIGWDSDPFDPLQKDGFIYARGAQDMKSAVASMICAVSGVQNFNGTISLLLTSDEEGDAVFGTREALKFLQSRGELPDFAVVGEPTCETVFGDTIKVGRRGSINGILRINGIQGHVAYPNKCVNPVHILASKFANFAGHDFDNGNDFFEPSKLVVVDIRGGMQVCNVTPSDVSVMFNVRNSNLTDANDIKNFINDLYKDCDFDLNLKVSSNPFLTDKNSKIVQKLSQSVQKISGVCPVFTTGGGTSDARYFAEFNVDVAEFGVINDRLHAVNERVSVNEVQKLTEIYKDLIENF
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: EPMA_EDWI9
Sequence: MSDMASWQPSAPVANLLKRASILSTIRRFFSDRGVLEVDTPSMSQATVTDVHLVPFQTHFVGPGVAQGMMLYLMTSPEYHMKRLLAAGSGPIYQLCRSFRNEESGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLECESAETLSYQQAFIRHLDVDPLSADKTQLREVAAKLDLSNVADNEEDRDTLLQLLFAFGVEPHIGKERPVFVYHFPASQASLAQISTEDHRVAERFEVYYRGVELANGFHELTDAAEQRQRFEQDNRKRAAAGLPQQPIDEHLLAALEHGMPDSSGVALGVDRLIMLALSAERLSEVIAFSVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: ATPE1_SYNC1
Sequence: MAQKLKLEMVTPAAQVLIEEVDEIAAPGSLGQFGVLPGHTPLLTTLQVGEFSYRKGSDVYYLAVNWGYVEVAEDRVLVLVETAETQDHIDLARAKAALGRAEARLRELTPADKEYHNMQAALQRAMVRIQVAGRGGRG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain 1, ATP synthase F1 sector epsilon subunit 1, F-ATPase epsilon subunit 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DNAJ_HISS2
Sequence: MAKRDYYEILGVQKGADDKEIKRAYKRLAMKYHPDRTKGDKESEEKFKEINEAYEVLADKEKRAMYDQYGHAAFEQGGGAGGFGGFSGADFGDIFGDMFGDIFGGGRSRQRVVRGEDLRYDIEISLEEAVKSCKKDIQINTLVHCGTCHGSGAEAGSKIESCPTCHGAGRVRRQQSFFVTEQTCPHCHGTGKKIEKPCHTCHGEGRVHKTQNLTVTIPMGVDTGNQLRLAGKGAAGENGAPAGDLYVVIHVKKHHIFERDGNNLYCEVPISFTMAALGGEVEIPTLDGRLKVKIPAETQTGKLLRLRGKGITSRGYAGDLICEIVIETPIKLNEEQKELLRKLEESLEGKTLQRPKSSGFLDGVKKFFDNLGK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP4_SCHPO
Sequence: MSDDRFAEDEIIQQRRKRRLEILKKYQQTGNGHSDLSIPEKKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDSPSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSFADMQDNWDDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRNRNQTFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMVFEMLSLNLRDILKKFGRNVGLSIKAVRLYAYQMFMALDLLKQCNVIHSDIKPDNMLVNEKRNILKICDLGSASDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILFPGRTNNQMLRYMMECKGKFSHKMLKRSQFLNDHFDADFNFIQIDHDPITNQETRKPVKFSKPTKDIRSRLKEVPTSTDEEFIIRQELMDLLEKCLELNPEKRVPPEVALKHPFFIKK
What is the function of this protein?
Has a role in pre-mRNA splicing and is essential for growth.  Phosphorylates srp1.
What are the official names of this protein?
Serine/threonine-protein kinase prp4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.