PharMolix/UniProtQA huggingface dataset:
Protein: NADE_XYLFA
Sequence: MSEFLRIAMAQFDFPVGAVAQNAERIIALIEQARDEHGADVVMFPELALSGYPPEDLLLRPGFLAHCQVAIERIAAATHGIVAVVGWPQSAGSVVYNVASVLCDGQVEQTYRKRELPNYAVFDERRYFEVDPNGSRCVFKVKGVPVGVLICEDLWFSEPLADTVCGGAELVLVPNASPYERGKHAQRDALLAERARETGAAIAYLNVVGGQDALVFDGASVVVDGHGRVHPAAAAFSDQWLVVDYMRSERRFVPLQWVAESEVSINALVWRAVVRGVQDYCRKNGFSKVWVGLSGGIDSALVLAIAVDALGADQVTAVRLPSRYTAELSNDLAAEQCHSLGVRLETVAIEPVFEGLLAALGPLFAGMAPDATEENLQSRSRGVILMALANKFGGLLLTTGNKSEYAVGYATIYGDMCGGYAPLKDIYKSQVFELAQWRNTVSDVLAIPPGVIHRPPSAELRAQQTDQDSLPPYEVLDGILSLYVDQEQSREDIIAAGYAAGVVDYVLNLVKINEWKRHQAAPGPKVSQRAFGRERRYPISNAYRG
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses L-glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing].
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: PARVB_HUMAN
Sequence: MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYKNVE
What is the function of this protein?
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6.  Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia.  Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
What are the official names of this protein?
Beta-parvin, Affixin.
What is the protein family that this protein belongs to?
Belongs to the parvin family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Protein: SAPR_STRPU
Sequence: MPPGPRGVASGKPVISGQDQKYTLADSSKDLEGIAHMAIVDSLSPLHISLSSLESAWNNLLNIASQEDYSIPELSIPKIDVKSILSCKPKYSPKYPVVLQYISDHYVQVQDHIANAKELTEGLKFVSQLIMYKKIDHDTLASVSKMLSNYLTDYASTISSLKSVVCQDQTAPSHPMDESYMDTPLSMILKGTMPTGAGVDKGFALGGGGVGKGFNLNGGGVGKGFDLNGGGVGKGFDLNGGGVGKGFDLNGGGVGKGFDLNGGGVGKGFALGGGGVGKGFSLTGGGVGREVEIKDW
What is the function of this protein?
Causes stimulation of sperm respiration and motility through intracellular alkalinization, transient elevations of cAMP, cGMP and calcium levels in sperm cells, and transient activation and subsequent inactivation of the membrane form of guanylate cyclase.
What are the official names of this protein?
Sperm-activating peptides.
Protein: RL18_SYNP6
Sequence: MKVSRRESTRRRHRRVRRTIVGTPARPRLSVFRSNNHIYAQVIDDAAGHTLAAASSLDPDLRQSLTSGGNQQASAAVGKLIAERAQAKGVTTVVFDRGGNLYHGRVKALAEAAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PUR5_SHIDS
Sequence: MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENTWKIGIIKASDSEQRVVIE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_SALPK
Sequence: MSGQQSSPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPINVFCAGRTDAGVHGTGQVVHFETTALRKDAAWTLGVNANLPGDIAVRWVKTVPDDFHARFSATARRYRYIIYNHRLRPAVLAKGVTHYYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLLEVGAHNQPESWIAELLAARDRTLAAATAKAEGLYLVAVDYPDRFDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: MDM10_NEUCR
Sequence: MREFMNYITNAFYGATGWNEDNKYNELNATSRELIDFPLPRGLRLTLSSLATPHFATSYQLGSVGVVDGSISYLHSSIPLTHIAAQSDKIPLPALLRCYRRLHDLRSPGQQHYILDADPLSGLPPPPQSARALLGAASDAAVAGGALDGGNTDQDLGIYTHSLLYGRLYLPKSLLEGMIIKRFTQALQVQVRAVSEQSLRNGGTILGLVQYDKGKYGLEGLYSTDGGLLGFRGLYNFGGDASSSTCDPWTPTPGENNNNNNNNNNNNNGNAQAGEKERIYGRFSVGGELYYGTLNKSGGMSLGARFATLPAHRGTPLTATLTINPLMGNINATYALLAREYCSLATRVDFNVYSYESEWAVGMELWSNRRPAGFLLGASPSNDFEPEPHPPRKKERSFQAKMEWRLDDPEPEPEPQPTPKTRKNDEYKGVLKARLDNNLRMGLLWEGRAKSLIFSIGTGIDLHKLGEPFRSLGLEVQYSS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the mdm12-mmm-1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component mdm10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: PIYH3_XYLFT
Sequence: MKKTVFNPALNRAAAILIGTLVGISGVVHASVDISSSPLHGGKDVPGNLAILASVEFPTLISVANLADTYTPGVRYVGYFDSNKCYKYHYSSRELDRYFYPVASPRPQANYGCNTTGGVWAGNFLNWAATQTIDPFRSALTGGYRVRDTVSETILEKAVMDRDSQENFPRRNVAGRNVLATLVPTQWNNFRIRIDGLGNRMRFTQFSSLWTDPLNTEGQPYDSSRHPLNRNDRGVYEVSVRVKVCDPSAGLESNCVAYPRGSYKPEGLIQEYSKRIRYSVFGYKNDHSYLIDGGVLRARQKFVGPQTHYPEQGKKTNSHAEWDPQTGILYDNPDPEDAAATTRRVGRTIANSGVINYLNKSGQMDTGRISKIYDPVSELYYTAYRYFKRLGNVPEYSVLTGSVNEKYQQADAFPVITDWDDPIRYACQSNVVLGIGDTHTNQDKNLPGNTNTMEEPSKPQTVRNDRSIDVVKRMAQIFRMEGMRQQDAMTSAVAPKFNFHRYNSAYIAALAYDAHTKDMRPDLEGDQLLTTHWVDVVEAGDYKIPISTNQYWLAAKYGGFQVPAGYDPDKTVNPLSEATWWTNGEYVNNDLKANAKRADNFYVAADAEKMVASLKHAFSRIVAEIKGAGTGLSSNSARLETGAVTYQAQFFSGTWRGDLIAYHVDKVTGALTPFWNANFPAWEQRVIKFANATTLQDFTKKNLGQTALASASAQQINYLRGDRSQEGNVPGKLRIRSGIMGDIVNSQPLYVGAPNGRLYTTANFTGASAYAAFAAQQANRVPVVYVGANDGMLHAFDANTGKEIFAFVPRAAMPKLLEYTDQNYGHQYYVDGELTAADIYDTKLGWRSVLVGTLGRGGKGLFALDVTDPSNIRLLWDKTSADIGGLGNTLSKPMIAQTSDGTWSVLLGNGPNSTADNAQLIVMNLLTGHAAQVPVSKTSNNGLSGVFPWSSQSNGITDRVYAGDLLGTLWRFTFSDNAWKVAPLFTATYQGKAQPISATPLGAIERSTGRMWIFFGTGRALSSHDMDNKEVQSWYGLIDQGTTIPGRTRLSQVQIVDEGVVNGYAVRTVSDPKNIGTDGWYMDLISPKSGKQGERMIVSNMFRGAALIGTTRIPDNSDICKLSGSGFVMAINPFTGGRLGQWFFDLNTGGGSGGALNGNPVSGVGVSSAPNSPVFTGNIMQIGADDGTVTSLKTPSSGGLNINRVSWREILRTE
What is the function of this protein?
One of the three PilY1 homologs of X. fastidiosa, which are involved in bacterial twitching motility as component of the filamentous type IV pili (T4P).
What are the official names of this protein?
Type IV pilus biogenesis factor PilY1 homolog PD_0023.
What is the protein family that this protein belongs to?
Belongs to the PilY1 family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: APOC3_RAT
Sequence: MQPRMLLIVALVALLASARADEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVASRGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP
What is the function of this protein?
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma.  Plays a multifaceted role in triglyceride homeostasis.  Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs).  Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.  Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
What are the official names of this protein?
Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_SYNJA
Sequence: MVWQRQHVLGLADFTPEEYQMVLQTSASFQEVLTRRLPKVPTLQGKVVVTLFFEPSTRTRSSFELAAKRLSADVLNFSPGTSSLSKGETLLDTARTFLAMGSDLLIVRHAQAGVPQQLAAEIDRRGSPVGVLNAGDGLHEHPTQGLLDLFTLCSHLDPRRPRLELLQGIKIAIVGDILHSRVARSDIYALVAAGAEVHLAGPPTLLPKDFAHFVPGHTLPVHWQLEPALEGARFVITLRLQQERMGEFLLPSLQEYHHFFGLTRQRLRLCHPDVKLLHPGPVNRGVELSSEVMEDPGLNLIEQQVTHGVAVRMALLYLMGGGRIPA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MSH5_CAEEL
Sequence: MSTRWRYYNSKRGNGFRGRGRGRGRGTSLTAVALPRDDNFHKGAQDGAYFKDMPMDPEQFRDETVLSLSFAQGMLGAAYYEQSSQLLKIMNDISEDLEFRFLKRLIDDVKPTLIIANRSQDLEFIKFLTTRYDPQEKIYEDGTTEEGTSEDTVPTWDSSLAYSTDETTAEKEEKEEDEDDDDEGLPAKLNKLPNNFFRMSRAIERLKAMAGSHDSSMTEEDKYIIIKMRFDIEAVNMIRSFGALLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQGRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISKEFPVESDLLREVSEIAVIAGSIINFAESKIQGRVTVMNGIDEELDEIRDTYENMPMVLTAIAKQEEARLGLPPYSNVACVYIPLVGFVLSVPRDYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSIIKLLSIASRIDVLISFGLIAAQNGWNCPALVDEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDNEKQLVEDMDVVLADEDGFMAAVESFVKRKKTSFCESSMRNVSEEIEKERSEASTPASKSRSTITARSNSVLSSRSMASVDQLSVLDALLPKKKKKKVTGSSMESSMSPDPFQEEDEGTEGEEDQISAPVSRPTLPSVQKYASEEEKQQSINSRHSFSTRTAIHIPTPIQMGEAGGVKRPRSTSTSSPGPSASKSVRTEVFKKTPNVKESQVLETPKQLSISSFLEPKFPSSEKDVISRVSERYLQSDPFKTPISDRRSQQSSRHSTPKNRSMNQSLIQSARDTPHETIRSSNEVNPEFFNIFNFPDDSILKSQDTYDPNVTPRSSSRRELRPDVSHSQNSQFGEVFSELGTQFSIFNSQQSFPGNSMGTTNPDCSIFDDFFANSQDGEKKIDSTKTSMPIVNSDNFIFKTPEPRSSEKQRSLLKNKGQASNSSISPSSLILGQLAFGDVDQTPRPRGDNPIEFQYDVVDDDDPIFEEKNCSAPVFEFLKSNDDEEDDEFLKSFLETEGSLHIDTSADETIDRSKRS
What is the function of this protein?
Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination.  Plays a role in promoting the crossover outcome of meiotic recombination events.  Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks.  Together with him-14 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114).
What are the official names of this protein?
MutS protein homolog 5.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Chromosome. Note=From mid-pachytene, co-localizes with cosa-1 and rmh-1 at crossover sites of early recombination intermediates (PubMed:29521627, PubMed:30379819). Co-localizes with brc-1 at crossover sites in mid-late pachytene nuclei (PubMed:30383754).
Protein: DNA2_XENLA
Sequence: MEPVSAECHLPPEDDLLEMMMEQSFTEPEEKSQDKPTRKIIPKTKLCKGVNNRYCVLHIKEVYAQREEKHLTITASQEGDDLELCILKDDWVALQIKPGDIIHLEGNCSVDNTWTISRDTGYLILYPDLLISGTSIANGIRCLRRSVLSEKFKVCDKGSRQMLNGTMLHDIFQRATTCGFTDSVLQELAHHTVHGPKYLKEMYQLKLNQADVMGEIQEYLPSLSKWATDFMTHPLNQQQINRTKSTAGDPTETTKVSEFLDIEENIWSPRFGLKGKIDVTARVKIHQKSKAHLKIMPLELKTGKESNSIEHRSQVVLYTLLSQERREDPEAGLLLYLKTGNMYTVPGNRLDRRELLKIRNELSYYLTNVLHKSDNGSKETTLASLPAMIADRQACKYCSQMRNCALYNRSVEQQTENCYIPPEMIPVVQKETEHLTEDHLQYFRLWYLMCTLEANSKDSKMGRKNIWMMSSSEREEDGQCIGNLIRTGHVQTISDVQYLHSFQRRSGSVPATNLASGDRVVVSGEERFLALSTGYIKEVKDENITCILDRSLVKLPEDLLFRLDHEEGGGGLEFHLGNLSRLMENSSVSEKLRKLIIDFSKPNFVQHLSSILPPDAKDIVASILRGLNKPQKQAMKRVLLSKDYTLIVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLKKFQVGFLRLGRTQKLHPDVQEFSEEEICKAKSIKSLSALEELYNSQPVVATTCMGVNHPIFTRRRFDFCIVDEASQISQPICLGPLFFADRFVLVGDHQQLPPLVKSAEARELGMSESLFKRLERNQEAVVQLTVQYRMNSKIMALSNKLVYEGRLECASDRVSNAVVQLPHIKTLLLELEFRESQESMWIKDVLEPSNPVCFLNTEKIPALETEEKGGISNWIEAKLVFHLTKLYLKAGCRPSDIGIIAPYRQQLKMISNYFNSLSASAVEVNTVDKYQGRDKSVIIVSFVRSNIDGKLGDLLKDWRRLNVALTRAKHKLIMLGCVPTLNRFDCLEQLICNLKTENQIYDLPEGAHEHFPV
What is the function of this protein?
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.  Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1.  Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.  Also involved in DNA replication checkpoint independently of Okazaki fragments processing (By similarity).  Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities.  While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.  According to various reports, the helicase activity is weak and its function remains largely unclear.  Helicase activity may promote the motion of dna2 on the flap, helping the nuclease function.
What are the official names of this protein?
DNA replication ATP-dependent helicase/nuclease DNA2, DNA replication ATP-dependent helicase-like homolog.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: FLRT2_RAT
Sequence: MGLQTAKWPSHGTFVLKFWLIMSLGLYSHVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIADGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTVSVPSPSRGSVPPAPAPSKLPTIPDWDGRERATPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHTMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
What is the function of this protein?
Functions in cell-cell adhesion, cell migration and axon guidance.  Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells.  May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D.  Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members.  Plays a role in fibroblast growth factor-mediated signaling cascades.  Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
What are the official names of this protein?
Leucine-rich repeat transmembrane protein FLRT2, Fibronectin-like domain-containing leucine-rich transmembrane protein 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Synapse, synaptosome. Cell junction, focal adhesion. Secreted, extracellular space, extracellular matrix. Microsome membrane. Secreted. Note=Proteolytic cleavage gives rise to a shedded ectodomain.
Protein: NMDE2_MOUSE
Sequence: MKPSAECCSPKFWLVLAVLAVSGSKARSQKSAPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVLADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGDKHGVVGGVPAPWEKNLTNVDWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVSSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMPAGESSFANKSSVTTAGHHHNNPGSGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKTRPDFRALVTNKPVVSALHGAVPGRFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
What is the function of this protein?
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.  Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:26912815).  Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365).  In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage.  Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836).  Contributes to neural pattern formation in the developing brain (PubMed:8789948).  Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948).
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Late endosome. Lysosome. Cytoplasm, cytoskeleton. Note=Co- localizes with the motor protein KIF17 along microtubules.
Protein: Y114_OSHVF
Sequence: MLSLNQLTEVMKVANKKREKFREMEHRFYHCCKKCSQAIGVFEENQETYKVVAMMCLDQVGIPVKTDTEKESTMLEFIRFFDNPRAAIKIPDRIVELTKEHMDDKEFLIDAVHNGRVKHSTVEMTKKKKADLLEVLMDPGKNNKKEDGDDPTLFFSINDMDQLLEGDDIIDMEEECEGDEDDVNAKGYDDLYDKKQKELYKKIETGMITVVRLHEMCNDLGIGDYFELILSATEFPCVICDLSILYEFRACFFDLINMSRMAASKVNLNRIKKPGKLFSKAIKNKTNAGCKPLVKGQFLGEKTELEITKRLDEVELTPKQLVDYSIFKCLGGGEDMMKTMAQLDKNNKMEDYGYNFFAEEISPPVLLRCMEGEWLDKFPFMRSIIDRIKDVALSHALPRKRIFCYINPRIMACECNIYETVRSRCLLGVKISLVNTMLKVMKRSQTKTILNQVSSICKEHGIAYEICNIHINKTMKEDKKIIKERLARKRSHPN
What are the official names of this protein?
Uncharacterized protein ORF114.
Protein: NQRC_CHLCV
Sequence: MSSEKPKPHLNKTWYVILFIFALSLFSSVFLSTVYYILAPFEERAAIFDRDQQMLTAAHVLDFSGKFQIYEEGSWQPAVYDKKSHLLKVADQHAPVVTSSVLDAYTQGFVRPLLADKLGQMFSFEEKNINVTEFIEKHQNGHFYQQPLLLFYVILANTEQARAMSAADVIKNPSVVRAIIIPISGFGLWGPIYGYLAVENNGDTVLGTAWYQQAETPGLGANIANPQWQKQFYGKKIFLQAAAGNTDFATTPLGLEVIKGSVQSAFGTTPKALSSIDGISGATLTCNGVTEAYAQSLAPYRNLLISFAKLNQRDHNGSK
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit C, Na(+)-NQR subunit C, Na(+)-translocating NQR subunit C, NQR complex subunit C, NQR-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the NqrC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CH60_SHIBS
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKLADLRGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKNDAADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.