PharMolix/UniProtQA huggingface dataset:
Protein: ENO_PLAFG
Sequence: MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKNINEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAANKVSLYKYLAQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSLVKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNACNALPLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLLRIEESLGNNAVFAGEKFRLQLN
What is the function of this protein?
Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity).  In addition to glycolysis, involved in various processes such as parasite development and invasion (By similarity).  Plays an essential role during ookinete invasion of the mosquito vector midgut by mediating the interaction of the ookinete with the midgut epithelium and, further, by binding to mammalian host plasminogen in the blood meal, whose conversion to active plasmin promotes the invasion process (By similarity).
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell surface. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole. Note=Partially localizes to the nucleus in rings and trophozoites. Localization to the nucleus and food vacuole is higher in early and mid-stage trophozoites compared to the late- stage trophozoites and schizonts (By similarity). In the nucleus, localizes to heterochromatin region (By similarity). In rings, nuclear localization is dependent on the actin cytoskeleton (By similarity). Localizes to the cell surface of merozoites (By similarity). In gametocytes, predominantly localizes to the actin cytoskeleton (By similarity). In the trophozoite food vacuole, colocalizes with hemozoin, a product of heme detoxification (By similarity). In sporozoites, localizes to punctate structures beneath the cell membrane (By similarity). Localizes to the cell surface of ookinetes, especially on the apical pellicle complex that is involved in invasion (By similarity). When phosphorylated at Thr-339, localizes to the cytoskeleton (By similarity). When phosphorylated at Ser-42, localizes to the cytoplasm (By similarity). When ubiquitinated at Lys-138, acetylated at Lys-133 and Lys-375 and phosphorylated at Tyr-139, localizes to the food vacuole (By similarity). When triubiquitinated at Lys-138, appears to colocalize with hemozoin in the food vacuole (By similarity).
Protein: FLHC_GALCS
Sequence: MAIKTVLGEAQQIKIATDLIVLGARLQVLQEETSLSRERLLKLYKEVRGESPSKGMLPYSTDWFISWQPNIHSSLFMGIYQFMIKNAGVDGVHALISAYRLYLDQVQGIEGGEVVLSITRAWFLVRFFKAGMMQLITCRECSGKFVTHTNELHNNYVCGICHPPARAGKTNAKARLLAGHAE
What is the function of this protein?
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhC.
What is the protein family that this protein belongs to?
Belongs to the FlhC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGA_HALH5
Sequence: MAEKPLRPLAEGELSIDQVKEQLVELGKKRGVLTYAEITEKLAPYDQDSDQMDEFFEYLGEQGVEILNDNEEVPSLQQVEKEEEEFDLNDLSVPPGVKINDPVRMYLKEIGRVPLLTAEEEIELATRIEQGDEEAKRRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLIKAVEKFDYNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVQRQLLQDLGREPSPEEVAEEMDLTPEKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDQDALAPSDAAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-43, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
Protein: CYB_MICSM
Sequence: MTNIRKTHPLMKIMNSSFIDLPAPSNISSWWNFGSLLGACLAIQIITGLFLAMHYTADTATAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGVYYGSFTLYETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIISALVLVHLLFLHETGSNNPLGTSSESDKIPFHPYYTIKDLLGLMFLLLTLTILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAIIPVLQTAKQRTMMFRPLSQIMFWILTADLFTLTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLIENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VCX1_YEAST
Sequence: MDATTPLLTVANSHPARNPKHTAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACASLLIPAAFRATLPHGKEDHFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNWLEGVMSLAMYILIAMAFFYYPDEKTLDSIGNSL
What is the function of this protein?
Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane.  Involved also in manganese ion homeostasis via its uptake into the vacuole.
What are the official names of this protein?
Vacuolar calcium ion transporter, High copy number undoes manganese protein 1, Manganese resistance 1 protein, Vacuolar Ca(2+)/H(+) exchanger.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: DLTC_STRPZ
Sequence: MSIEETVIELFDRLFMEDVSEMMDEDLFDAGVLDSLGTVELIVELESTFNIKVPISEFGRDDWNTVTKIVQGVEELQHA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_CHRSD
Sequence: MPDRSLPPAQRALFDALLDHGLSEWVARLPAQLADGLDRKRFGDLPAWEKAVAKLPTLPEARDVALDSDSVRVDLALTESQQRQCENLLRKLMPWRKGPYTLGGIHIDTEWRSDWKWQRVAPHLSPLEGRRVLDVGGGNGYHGWRMVGAGAAFVLIVDPSPRFYYQFQAVRHFVGDADGWRTHFLPVGIEAVPPKLEAFDTTFSMGVLYHRPSPLEHLMQLRDTLRPGGELVLETLVVEGDANTVFMPGERYAAMPNVYFLPSSKALAHWLERCGFEDVRVVDEAPTSLAEQRSTEWMTFHSLADFLDPEDATLTLEGYPAPRRAVLVARKPE
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: LDB2_MOUSE
Sequence: MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTTNSAGSKKKTPAASLSLATQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENAPPQASQ
What is the function of this protein?
Regulates the transcriptional activity of LIM-containing proteins such as LHX3 or PITX1.
What are the official names of this protein?
LIM domain-binding protein 2, LDB-2, Carboxyl-terminal LIM domain-binding protein 1, CLIM-1, LIM domain-binding factor CLIM1.
What is the protein family that this protein belongs to?
Belongs to the LDB family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with SLK at leading edges (PubMed:19675209).
Protein: IGF1_ONCMY
Sequence: MSSGHFFQWHLCDVFKSAMCCVSCTHTLSLLLCVLTLTSAATGAGPETLCGAELVDTLQFVCGERGFYFSKPTGYGPSSRRSHNRGIVDECCFQSCELRRLEMYCAPVKSGKAARSVRAQRHTDMPRTPKVSTAVQSVDRGTERRTAQHPDKTKPKKEVHQKNSSRGNTGGRNYRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LSPA_BORHD
Sequence: MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFSIGANINSSLKNLFFLVIPIIILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPLGVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYDLFAKNKSTDL
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECA_LACLS
Sequence: MATKKKTNFDDITKKYGAERDKALADALALIEKDFGKGSLMRLGEAANQKVSVVSSGSLALDIALGAGGYPKGRIVEIYGPESSGKTTVALHAVAAVQKEGGIAAFIDAENALDPEYAKALGVNIDELLLSQPDYGEQGLQIAEKLITSGAVDLVVIDSVAALVPKAEIDGEIGDSSVGLQARMMSQAMRKLAGHINKTKTTAIFINQLREKVGVMFGSPETTPGGRALKFYASVRLDVRGSTKIEEGSGDNKTQIGKITKIKVVKNKVAPPFKVALVDIMFGEGISSTGELLNIAVEEGIIKKSGAWFAYNDEKIGQGAEKAKNYLKEHQDVFDEIDHKVRAAHGLLDDSEVAETEEETTASKTKAKAKKEEKAVETEEIELELED
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_CAMC1
Sequence: MIQSFTRLAVADNSGAKELMCIKVLGGSKRRYATLGDIIVCSVKKALPNGKIKKGQVVKAVVVRTKREVQRDNGSLIRFDENAAVILDSKKEPVGTRIFGPVGREVRYANFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RL13_VESOH
Sequence: MKTFSAKARDVKRDWLLIDADGKTLGRLATKIASCLRGKHKPEYTPHTDIGDYIVVINASKIKVTGNKFEDKIYYHHTGYVGNLKSIAFKDLQTKNPETIINKAVKGMLPKGPLGRDMFKKMKVFVDSEHTHGAQQPKVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ISU1_YARLI
Sequence: MMFNRITRSAGLLARARPTTTAVMSPMTPLAISRRGYHEKVLDHYNNPRNVGSMNKNDEDVGTGLVGAPACGDVMKLQIRVDDNGVIQDVKFKTFGCGSAIASSSYVTELVRGKSLAEAGKIKNTVIAKELSLPPVKLHCSMLAEDAIKSAISDYNSKRKTKNPTLGAEAAETPAAATATA
What is the function of this protein?
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.  First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1.  In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins.  Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.
What are the official names of this protein?
Iron sulfur cluster assembly protein 1, mitochondrial, Iron sulfur cluster scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VL2_HPV20
Sequence: MARAKRVKRDSATNIYRTCKQAGTCPPDVINKVESTTIADKILQYGSAGVFFGGLGISTGKGTGGTTGYVPLGEGPSVRVGGTPTVIRPALVPDTIGPSDIIPVDTLNPVEPSTSSIVPLTESTGPDLLPGEVETIAEIHPGPSRPPTDTPVTSTTSGSSAVLEVAPEPTPPARVRVSRTQYHNPSFQIITESTPTLGESSLADHIVVTSGSGGQAIGGMTPELIELQDFPSRYSFEIEEPTPPRRTSTPMQRLQNVFRRRGGLTNRRLVQQVPVDNPLFLTQPSRLVRFQFDNPVFEEEVTQIFEQDLDTFNEPPDRDFLDVQSLGRPQYSETPAGYVRVSRAGQRRTIRTRSGAQIGSQVHFYRDLSSIDTEDPIELQLLGQHSGDATIVQGPVESTFVDINVDENPLSEISAYSDDLLLDEANEDFSGSQLVVGGRRSTSTYTVPHFETTRSSSYYVQDTKGYYVAYPEDRDVSKDIIYPNPDLPVVIIHTYDTSGDFYLHPSLTKRLKRKRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: MNMG_BURP0
Sequence: MLYPTEFDVIVVGGGHAGTEAALASARMGAKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRVLYKQAIRRRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGVRFRARAVVLTAGTFLDGKIHVGLNHYTGGRAGDPAAVSLSSRLKELNLPQGRLKTGTPPRIDGRTIDFSKLDEQPGDLDPIPVFSFLGRAEQHPQQLPCWVTHTNERTHDIIRSGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKDSHQIFLEPEGLTTNEFYPNGISTSLPFDVQLALVHSMRGLEQAHILRPGYAIEYDYFDPRALKSSLETKAIGGLFFAGQINGTTGYEEAAAQGLLAGINAGRYAQEKDAWCPRRDQAYLGVLVDDLVTRGVSEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGVVDDVRWDAFNRKRDAVSRETERLRTTWVTPKTLPADEATALLGKPIDHEYSLAELLRRPGVSYDGVCGLRGGECGPSEPLAEDELLLAQIKEQIEIGIKYQGYIERQAGEIERNGANENTRLPDGIDYTEVRGLSFEVSQKLNQFRPETIGQASRISGMTPAAISLLMVHLKKRGLGRRKGADSVPGADVQADNTAAQQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FA24A_HUMAN
Sequence: MAKMFDLRTKIMIGIGSSLLVAAMVLLSVVFCLYFKVAKALKAAKDPDAVAVKNHNPDKVCWATNSQAKATTMESCPSLQCCEGCRMHASSDSLPPCCCDINEGL
What are the official names of this protein?
Protein FAM24A.
What is the protein family that this protein belongs to?
Belongs to the FAM24 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_MYCSS
Sequence: MASTADFKNGLVLQIDGQLWQIVEFQHVKPGKGPAFVRTKLKNVVSGKVVDKTYNAGVKVETATVDRRDATYLYRDGSDFVFMDSEDYEQHPLPESLVGRAADFLLESMPVQIAFHDGVPLYLELPVTVELLVASTEPGLQGDRSSAGTKPATMETGAEIQVPLFINTGDKLKVDSRDGSYLGRVNA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAA_FRATN
Sequence: MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREIIVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLGILALLGTRVPAKLKLLVITIAIFDDIAAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFRENDKDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIILGLFVGKQLGIFSILAVFKKLKWFKLGESFSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ODP2_NEUCR
Sequence: MIVPVLSRQALRHASVARVALPSLTRWYASYPPHTVVKMPALSPTMTSGGIGAWQKKPGDKIEPGEVLVEIETDKAQMDFEFQEEGVLAKILKDSGEKDVAVGNPIAILVEEGTDVNAFKDFTLKDAGGETSPAVPKDEPKNESTASAPTPAPTPAPEPENTSFTGRFQTALEREPNALPAAKRLAREKGIDLRNVKGSGPGGKITEEDVKKALASAPAAGAAAAAYTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQALNSSADGRYKLSVNDFLIKAMGIASKRVPTVNSSWRDGVIRQFETVDVSVAVATPNGLITPIVKGVEGKGLESISAAVKELAKKARDGKLKPEEYQGGSISISNMGMNPAVQSFTAIINPPQAAILAVGAPQKVAVPVENEDGTTGVSWDEQIIVTASFDHKVVDGAVGAEWIRELKKVIENPLELLL
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, MRP3, Pyruvate dehydrogenase complex component E2, PDC-E2, PDCE2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NADA_CLOAB
Sequence: MDQNLKEQILELKRQKNAIILAHYYQRPEVQEIADFIGDSYNLSKIAKENDADTIVFCGVKFMAESAKVLSPQKKVLLPQPKAGCPMADMADAEGLAALKAKHPNAKVVSYINSSVEVKALCDTCCTSSNAAKIVKRIDSDEIIFLPDKNLGSYVQEMVPEKNIILWDGFCKVHNMIIPTDIEEMKNKYGDMKILAHPECWKPVRDMADFIGSTGAMIDYAEKDTTSDKYLVVTETGIMYKMQERVPNKTFYPLRSMVCVNMKATHLEDVYNSLVNSTFEINIEENLRQKALTSLENMLILGR
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP27_MOUSE
Sequence: MCKDYVYDIDIEQIAKEEQGEALKLQASTSTEVSQQQCSVPGLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKVASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSLNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMKKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKETRVNGQLQLPTNSANNENKYSLFAVVNHQGTLESGHYTSFIRHHRDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEPEPEKVKEMTPQAY
What is the function of this protein?
Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008).  Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (By similarity).  Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (By similarity).  Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008).  Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (PubMed:27013495).  By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (PubMed:27013495).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 27, Deubiquitinating enzyme 27, Ubiquitin thioesterase 27, Ubiquitin-specific-processing protease 27, X-linked ubiquitin carboxyl-terminal hydrolase 27.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RS4E_THEKO
Sequence: MARKGPKRHLKRLAAPTSWYIHRKAYKWAVRPSPGPHSMKTSIPLIYIVRDYLGYAKTAREARKILNEGKILVDGRVRKDYKFPVGIMDVVSIPETGEHYRVLPNRIGKLILHPISEEEAKLKPFRINNKRMVKGAKVQLNLHDGSNHLVSLAEKDAYKTSYTVIMQVPERQIVKVLPFEVGAYVFVTQGKNVARKGKIVEVRQFPMGWPDVVTIEDENGELFDTLKEYAFVIGKDKPEISLP
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.