PharMolix/UniProtQA huggingface dataset:
Protein: MURD_PROMM
Sequence: MARTVVVGLGRSGIGAARLLQAEGHQVTVLERSIEPHLQSLAADLRLQGIAVELGKPLELNSFIPLLDQLDAVVISPGIAWDHPTLTALRQRGIDIDGEMAVAWRSLSHLPWIAITGTNGKTTVTHLLNHVLESNGLRAPMGGNVGHAAAEVALKWRQPNAQRPDWLVMELSSYQIEAAPEIAPRMGIWTNLTPDHLERHGTLDAYRTIKRGLLERSEIRIFNGDDPDLRSQRSSWDKGLWVSSEGPGTANHRADFWIDAEGLVREPQGALFAASALAMPGQHNLQNLLLVTAAARQTGLPAKAIEASLRSFPGVPHRLEQLGHIQQMSVYNDSKATNYDAACVGLKAVPPPAVVLAGGQTKQGDASGWLKQLDQNACAVILFGAGASELQELIKTSGFSGELHCCSNLNAAVTLAIPLGVERQAACLLLSPACASFDQYQDFEARGEHFRSLISSHLTA
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_THESQ
Sequence: MKKEKKDYYEILGVPRDATQEEIKRAYKRLVKEWHPDRHPENRKEAEQRFKEIQEAYEVLSDPQKRAMYDRFGYVGEQPTYQETESGGFFDDIFREFENIFNRDIFDVFFGERPHQEERREYARRGEDIRYEIEVTLSDLINGAEIPVEYERYETCPRCGGTGVEPNAGYINCPSCGGTGRIREERRSFFGYFVSERTCERCGGTGKIPREYCHECGGSGRVLRKVRKTVKIPPNVEDGTQLRITGGGNAGYYGGPYGDLIVIVRVKPDPRFKKSGSDLVYDITIDYLQAILGTTVEVPLPEGGTTMLKIPPGTQPETVFRLKGKGLPNRYGRRGDLIVNVHVEIPKSLSREERKVLEELAKKRGVTID
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_INCGL
Sequence: AEKIKICLQKQANSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNSAFPRSADVSAKTADKFRSLSGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAIDCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQVTAEVAKNCNNSFLKNPALYTQEVNPSKQICGEENLAFFTLPTQFGTYECKLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNTGDTPTMQCDMLQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGLVTAVQSVWGKGRKSDYAVDQACLSTPGCMLIQKQKPYIGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGNDDLIIGLLFVAIVETGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRITHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITTPISLAALAISGIAICRTK
What is the function of this protein?
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.  Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase.  This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity).
What are the official names of this protein?
Hemagglutinin-esterase-fusion glycoprotein, HEF.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: PURA_THET8
Sequence: MPGIAIIGAQWGDEGKGKVVDVLAREADYVIRYQGGANAGHTVVAEGKVFKLNLLPSGVIHPHAVNVLGDGMVIDPFRFQEEVEGLRKEGFDPKILVSERAHLVLPHHKHVESRHNFVGTTGRGIGPAYSDRARRVGIRAGDLLDEATLRERVRRLLAEKPNSTREAGWDTEEKALADLHRMREILSPYIADTGSLLREAWRKGKRLLFEGAQATLLDLNYGTYPYVTSSHPTVGGILVGTGLSHKAITKVYGVAKAYTTRVGEGPFPTELQGELAHHLREKGGEYGTTTGRPRRVGWLDLVALRYACEVNGFDGLVLTKLDVLSGLEKVKVAVEYLDGARPGEASPEAVRYLELPGWGDLSHVKRREDLPANLLRYLELVEEHTGVPVVLFSTSPRREDTFGAVSWV
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_HALH5
Sequence: MSRIGNKPVEIPSGVTVTVNGADVTVKGPKGELKRTFNPEIVVKVEDNTVVVERPSDKKEHRALHGTTRSLISNMVEGVSKGFEKSLELVGVGYRAQKSGQKLVLNVGYSHPVEIVPEKGIEIEVPSNTKVTVKGIDKERVGAVASNIRSVRLPEPYKGKGIRYEGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL36_CORGL
Sequence: MKVRNSLRSLKNKPGAQVVRRRGKVYVINKKEPRFKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: TRPD_POLNS
Sequence: MSITPQEALQRCIEHRELFHDEMTAMMRLIMSGEMSPELVAGLLIALRTKKETVGEIAAAAQVMREFATSVQVDDRTHLVDVVGTGGDGAHTFNISTAAMFVAAGTGAKIAKHGNRSVSSKSGSADVLEALGVNLALSADQVAKCISTVGTGFMFAPNHHPAMKNVVPIRKQLGVRTIFNILGPLTNPADAKRILMGVFHPDLVGIQARVLQALGMEHALVVYGRGGLDEISLGGPTLVGELKDGVVREYEIHPKDFGLNTAPTNSFKVANAEESKKIVLDVLDGKPGPASDIVCLNAGATLYVAGIAKSIASGIALAKTAITSGAARQKLDTFVVTTQSK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: LMO4A_XENLA
Sequence: MVNNRSSESTTTAVSSNGSPPKACAGCGGKIGDRFLLYSMDRYWHTRCLKCSCCQAQLGEIGTSCYTKSGMILCRNDYIRLFGNSGACNACGQSIPASEMVMRAQGSVYHLKCFTCATCRNRLVPGDRFHYVNGTIFCEHDRPTGLLNGHLNPLQSNPLQGSPMLPDQKVC
What is the function of this protein?
Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation.  Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors.  At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary.
What are the official names of this protein?
LIM domain transcription factor LMO4-A, LIM domain only protein 4-A, LMO-4-A, Xlmo4.
Protein: CYC21_MAGML
Sequence: ADAPPPAFNQCKACHSIDAGKNGVGPSLSGAYGRKVGLAPNYKYSPAHLASGMTIDDAMLTKYLANPKETIPGNKMGAAFGGLKNPADVAAVIAYLKTVK
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2 iso-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
Protein: NQRD_PSEAE
Sequence: MMAAQPTIREVLFNPVFQNNPIGLQILGICSALAVTSNLKTATVMAIALTLVTGFSNLFISMIRRQIPSSIRMIVQMVIIASLVIVVDQVLKAYAYSLSKQLSVFVGLIITNCIVMGRAEAFAMANPPLVSFFDGIGNGLGYSAMLLVLGFVRELFGAGKLYGISVLPTVNDGGWYQPNGLLLLPPSAFFLIGLIIWALRTWKKDQVEAPTYKMAPQVSSKEAY
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF3_ECO27
Sequence: MKGGKRVQTARPNRINGEIRAQEVRLTGLEGEQLGIVSLREALEKAEEAGVDLVEISPNAEPPVCRIMDYGKFLYEKSKSSKEQKKKQKVIQVKEIKFRPGTDEGDYQVKLRSLIRFLEEGDKAKITLRFRGREMAHQQIGMEVLNRVKDDLQELAVVESFPTKIEGRQMIMVLAPKKKQ
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLF6_HUMAN
Sequence: MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL
What is the function of this protein?
Transcriptional activator (By similarity).  Binds a GC box motif.  Could play a role in B-cell growth and development.
What are the official names of this protein?
Krueppel-like factor 6, B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOC_HAEIN
Sequence: MGSLTSVDKSRIRQAFQKALNDYDRHALIQQKMTINLMAHLQDYLPNGSLDSVLELGCGSGMLSSLLQKQISADYWLFNDLCDVQTQLAEKLPQSFDFYCGDAEHFLFLQQFDLIASASAVQWFHQPDAFIAHCKTGLKTNGLLAVATFGEDNLKEVRQITNIGLNYPTLSQWQTWLAKDFELLWCEDFKVILDFDTPLDVLKHLKYTGVTATNQKNWTRKNLNGFIGDYLSAFGMPSGKVRLTYHPLFFIARYSHIENQ
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: MURG_TRIEI
Sequence: MGKGEFTFNLLCCYNREAETLTNKPVKLLIAASGTGGHLFPAIAIANQLKDYHIEWLGVPDRLETKLIPSQYPLHTISVEGFQQKLGIETLKVLSRLIGSILKVRHILKEGKFQGLFTTGGYIAAPAIIAARYLGLPVILHESNVLPGKVTRWFSRLCNVVAVGFEEGTKYLSFEKTVYLGTPVREEFLFPQSLDLPIPENVPVIVIVGGSQGAVAINQLVRKCIPAWVENGAWIIHQTGENDPNAFSLKHPQYFTLPFYHNMASLFQRANLVISRAGAGSLTELAVTHTPSILIPYPYAADNHQAYNAKIFSNQNAALVFTEGELTPEKLQTEVLELLQSSEKLEKMSLGAESLAVKDSHKKLAGLVHEILSH
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACHB_TETCF
Sequence: MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNNDGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NUOB_SINMW
Sequence: MELASGTTLVAPQPKGILDPATGKPIGSNDAFFGEINNELADKGFLVTSTDELITWARTGSLMWMTFGLACCAVEMMQMSMPRYDAERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPTAEALLYGVLLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TI214_CALFG
Sequence: MILKSFLLGNLLSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMEEGTEKEVSATTGFITGQLMIFISIYYAPLHLAMGRPYTITVLGLPYLLFHFFWKNHKHFFDYGSTNLNSMRNFSIQSIFLNNFIFQLLNHFVLPSSTLIRLVNISMFRCNNKTLFVISSFVGWLIGHILFMKWVGLILFWIQRNRSIRSNPLIRSNKYLVSELRNFLSRMVNIFLFITCVYYLGRIPSPILTKKLKETSETEEGEENEDETNVEIEKFSEAKETKQEQKGSFAEEDSSLGSEEREDPNKLYGKKRKGYQENWKFEILKDKDLFWFEKPIVTLLFDYKRWDRPLRYIKNDRFANAVRNEMSQYFFHKCPVDGKQKISFTYPPSLSIFFEMIEKHLSLCTTEKLSPEDLYNHWVYTNEKKRCNLNNEFINRIEALNKGSLSMHVLEKRTRLYNDKNEQECLPRMYDPFLNGPYRGTIKKVYSHSILDASTTSTEDSLRVVWINKIDDILPTNYQEFEEKMDPFNGESLSTDINHSLASTSELAGESPMDFRFNLKEGLVLPAEQKQRRFDSENPMKYLKFLFDAITTDTPNYKTIQTKSIGIEEIGKKVPRWSYKLTNDLQQQERENEEESTEDHAIRSRKSKRVVIYTDNDKNPNTPISTNGNQAEEVALIRYSQQSDFRRDLIKGSRRAQRRKTVTWEIFQANVHSPLFLDRIDKTFFFSFDISGTINLAFRNWTEKGSEFKTSNSDEKETKEKEKKREDKKEENERIAIAETWDTIIFAQAIRGIMLVTQSILRKYIVLPSLIIAKNLVRMLLFQFPEWYEDLKEWNREMHVKCTYNGVQLSETEFPKDWLTDGIQIKILFPFCLKPWHRSKLRPHHRDPMKKKGKKDNFCFLTVWGMETELPFGSSRKRPSFFEPILKELEKKIRKAKKKYFLVLSVLKEWFRKVSKEKTRWIRKIVLFIKKIIKEFAKVNSILLFGRKKVYESNENKKDSITIISNKILSEPTIRIRSMDWTNYSLTEKKMKDLADRTTTIRNQIERITKEKRTIFLTPDRNGSPNETSCDDKRSESQKHIWQISKRRSAWFIRKWRYFIKIFSERIYIDIFLCAINIPRVNAQLFFESTKKILDKYIYNDQRKKEGIDETNPNKLISISKKYFSNISNKKSRIYWDLSSLSQAYLFYKLSQTQVINKYRLKSVLQYRDLFLRDRIRDYLGTRGIFDSKFKKLPNSGMGEWKNWLRGHYQYNLSQTRWSRLVSKKWRDRVNQHRTIQNKDYKRDSYEKDQFIHYEKQNDSVVNSLPSQKEKFQKHYRYDLFSYKYINYGVNYGDSKDSYRSPLQVNEDRGIPYNYNTPKSESVFVLGGIALSDYLEEKYIIDRGKSRDKKYLEWKILNFCLRKNIDIEAWTNINKNTKIGTNDYQIIDKKNPFYLTTYQEINPLNPKSFFFGRMGMNQGMLYRPIANLEPWFFSEFVPLYDAYKIKPWIIPIKLLLFNFEGNETISENKNINGNKKGELPISSNQKDYLELENRNQEEKEEFGQGNLGSDTQNQQKDVEKDYAKSDIKKRGKKRQSKSNKGAELQFFLKRYLLFQLRWDDPLNQRMMNNVKVYCLLLRLINPREIAISSIQRGEMRLDVMLIQKDLTLTELIKRGILIIEPVRLSIKWDGQFIMYQTIGISLVHKNKHQTNRRYREKRYVDENYFDGSIAQHGKMLVNRAENDYDLLVPENILSPRRRRELRILISFNSGNRNVVDRNLVFFNGNNVKNFGQFLDEDKHIDTDINKFIQFKLFLWPNYRLEDLACINRYWFDTNNGSRFSMLRIHMYPPRFGIG
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: DEP1B_MOUSE
Sequence: MEHRVVGPGPYRATRLWNETVELFRARMPLRRHRCRFKSYEHCFTASEAVDWLHELLRNSQNFGPEVTRKQTVQLLGKFLKNHVIEDIKGKWGQEDFEDNRHLYRFPPSSPLKPYPKKPLYQRDVIKFPEWNDPPPGTSQENIPVRPIVMNSEMWFKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSTTLSYLQKILGLDSLEEVLNTKLVSSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNCTDWKQPMYLGFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLLPKEKTAIEAFQLCCLLLPPENRRKLQLLMRMMARICLNKEMPPLSDGFGTRTLMVQTFSRCILCSKDEVDLDELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQISPEEFEYQRAYGSQEPLAALLEEVIADDKLSSKEKKKKLKQFQKSYPEVYQERFPTPESEALLFPEKPKAKPQLFMWALRKPFQPFQRTRSFRM
What are the official names of this protein?
DEP domain-containing protein 1B.
Protein: ATP5I_BOVIN
Sequence: MVPPVQVSPLIKLGRYSALFLGMAYGAKRYNYLKPRAEEERRLAAEEKKKRDEQKRIERELAEAQEDTILK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane.
What are the official names of this protein?
ATP synthase subunit e, mitochondrial, ATPase subunit e, ATP synthase membrane subunit e.
What is the protein family that this protein belongs to?
Belongs to the ATPase e subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: MDTA_DICZ5
Sequence: MNAARLFRFLILLVVIAAAFFAWRYFRPSQSDSANEATTTQHASPQGQGQNRSGSGRRGSTAPPPVQAALSSSSSVPYYLSGLGTVTAANTVTVHSRVSGQLMAIHFQEGQQVKEGELLAEIDPRPFQVALIQAQGQLAKDQALLVNARQDLVRYQQLSKTNLVSGQQLDTQESLVRQYEATVKSDQGAVASAQLQLDYSRITAPFNGRVGLRQIDIGNYVTSTDNLLVLTQTHPIDVIFTVPESDIATVLKAQKSGQPVPVEAWDRGSQRILSQGRLLSMDNQIDATTGTIKLKARFDNTDDALFPNQFVNIKMKVDTLQNVVIAPSAAIQMGNEGHFIWVLNDKDQVSKHIITTGIQYGQQTVVSNGLNAGERVVTDGIDRLTEGARVEVLAPAAADSKSTAGAEKPQHEKSQHNAEKS
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CXA1_BOVIN
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVVAQTDGANVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHTTTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDHQNSKKLDAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.  May play a role in cell growth inhibition through the regulation of NOV expression and localization.  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43, Vascular smooth muscle connexin-43.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65.
Protein: QSEB_ECOLI
Sequence: MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK
What is the function of this protein?
Member of a two-component regulatory system QseB/QseC.  Activates the flagella regulon by activating transcription of FlhDC.  Currently it is not known whether this effect is direct or not.
What are the official names of this protein?
Transcriptional regulatory protein QseB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_WIGBR
Sequence: MKIRPLHDRVIIKRKEAESKSAGGIVLTGSAAGKSTRGKVLAVGNGRILDNGETKPLDVKIGDIVIFNDGYGVKVEKIDNDEVLIMSESDILAIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_SALAR
Sequence: METLAQHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.