PharMolix/UniProtQA huggingface dataset:
Protein: PURA_PARBP
Sequence: MVTIVLGAQFGDEGKGKITDLLSQSATLCCRAAGGHNAGHTIVHDDITYDFHILPSGLISPDCINLVGTGTVVHVPSFFKELDALKAKGLKDADKRIFISDRAQVCFDLHSVVDGLEEAILAGKKVGTTGKGIGPCYSDKASRRGVRIGEVLEKGVVESKLRALEAGYRRQFGELKYDLEDEVKRFHEYRTKLQPYVVDQMAFMHKHRSSPSVLVEGANALLLDIDHGTYPYVTSSCTGLGGAIQGLTLNPTSIKSIVGVVKAYSTRVGSGPFPTEQNNAVGEKLQRAGREFGVTTGRRRRCGWLDMVMCRYSNAINHYTVINLTKLDILDDFDEIKVAVAYQLDGKLLESFPAQADVLDKVEVKYVTLPGWKSNTMGATKWEHLPTNAQRYVEFIEREMGGVPIRWIGTGPARNHMIERI
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOL_TUHV1
Sequence: MSTVTFFNPYLCGPRKPRAPSAGEGGAEGAAAARARAASAPFLQIVPRGCLYDGERGLLKHNCALAPRMFFRDRPYVLSKDLVWPTLPPPAVPASTTERAPRAPAPSADLLFHMYDQAETVVSADSKELIHPGYRHRITPCGVVLRLFGRTADGASLCVNVFGQDAYFYCRYGDAQSLHDRLYRLSDTLELAPVFHVRVRRVQRCSIYGYGTRPFADLYLVACGNWHVLKKMGQCLLDEGVEVFEVGVSPLTRFLLDKKIPSFGWCRLRRWHARPAHGRLSTAELEVDCEVADVRGVDDVAWPLYRCLSFDIECLSGGGAFPVAENLDDVVIQISCVCYPVGGTEEQRAAFPVAERHLFTLGPCAPIPGVLVYEFPSEFELLCGFFTFFGRYAPEFVTGYNINNFDWRYLLTRAERVYRWPVAEYTRLRFGGRFCAYVPGGGGRQPGFRTAQTKVLITGTVVLDLYPVCMAKVSAPDYKLNTVCELYLGRQKEDLSYKELPRAFLSGDAGRARVGRYCVQDAVLVKELFEKLNYHYEAAAVARLARISLRKVIFEGQQIRIYTCLLEEAAARQMVVPTFRSGAQRGAATGAGGGGGEETTYQGATVFEPTVGYHHAPVAVFDFASLYPSIIMAHNLCYSTWLRDDPGTPARPPETPARPPETPAAGPSGAAHAGGVPGATFRTPFRTPAGVPAAAAGGVGAGPPGGGAVSSASVGGRAAVSPSETPAEREPEPAPEDVFVVHVGQGVSYRFVRENVRASILSELLRRWLAQRRAVREAMRECEDETRRLLLDKEQLALKVTCNAFYGFTGFSQGMLPCLPVAASITTIGRDMLSRTSAYIEAHFAEPAFLARFFEPGDLPRADEPPPTVRVIYGDTDSVFVRFGGVRAGAIVARGEDLAAAVTEALFTEPVKLEFEKLFVALMMICKKRYIGRVFGSDALVMKGVDLVRKTACRFVKTVVRDVVELVFRDAAVAEAATRMSELTLEEMRRVGVPAGFHVLLQRLARARDDLFSGRVETAALVLSSVLSQDVSRYKQLNLPHLAVIRRLAARSEELPSVGDRVSYVLTAGPPDGRANAPNYELAEDPDYVAAHRVPIHAAKYFEQVVKAVTNTLYPVFPRGVVRRDRFLADLVPKRVYLGDEFKRHARPVEEEVCESERGGSGLLSSLDSSR
What are the official names of this protein?
DNA polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RS17_ECO81
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: YUBO_CAEEL
Sequence: MSYGPQLPAFLMKGQIKENEVDDEAEEGAPQVYGPVIPGMEEPKNEKEKHDDQEETSVFGPSIPKEVREKLQNVENPAEDDEEDEEFPSQSYGPSIPSNFRPTVGPSIPGTFGDDSDEDIGPMPVAKGDEEKEAIDRAYRMVLQKEAEDDEKNFQPKREEWMTSVPKKLGNFGLGARTFKKGTTSERDASWEDAPGAKKRRNEETRSARSVGIAAADARQAAIVAEKTSGPSLLEIHQKKRDEKVKDAGYAQGERRPFDREKDMEVRGLKPGGSKEAVDRMKEFADRFANSKDQRFL
What are the official names of this protein?
Uncharacterized protein F26A3.7.
Protein: ALR_SODGM
Sequence: MPRPIVAKVDSAVLASNLSIVRRHAPQAQVWSVVKANGYGHGLNTVWQGLQQTDGFALLDLHEAVVLREKGWRGPILLLEGFFQPADLAVIDRYRLTTVVHSDWQIEALRRMTPRAPLDIYLKLNSGMNRLGFSERALPGAWQSLNALKHVATLTLMSHFAYADMPEGVEGQMAVVARAGEGLTGPRCLANSAATLWHPATHGQWVRPGIILYGASPSGNWQDIAASGLRPVMTLQSELIAVQSVPAGGRIGYGGRHRVSETHRVGVVACGYADGYPRHAPTGTPILVDGVRTSTLGAVSMDMLMVDLQLCPKARIGSAVELWGDHVKIDEVAASAGTLGYELMSALAPRVTVQIR
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: SYI_BRUAB
Sequence: MTDTTKIDYSKTLYLPQTEFPMRAGLPQREPLFVQRWEEMNLYKKLREQAKDRPLYVLHDGPPYANGNIHIGHALNKILKDVITRSFQMRGYNSNYVPGWDCHGLPIEWKIEEKYRAAGKNKDEVPINEFRKECREFASNWIKVQTEEFKRLAILGDFENPYTTMNFHAEARIAGELLKFAASGQLYRGSKPVMWSVVERTALAEAEVEYHDIESDMIWVKFPVAGEVATENDLSGSAVVIWTTTPWTIPGNRAVSYSSRIEYGLFEITEAENDFGPRPGERLVFADKLVEECCAKAKLQFKRLRSVSAEELGKIVLDHPLKGFGGGYEFVVPMLDGDHVTDDAGTGFVHTAPSHGREDFEAWMDNARQLEARGIDPNIPFPVGDDGFYTKDAPGFGPDREGGPARVIDDNGKKGDANKVVIEQLIAADKLFARGRLKHSYPHSWRSKKPVIFRNTPQWFVYMDKNLGDGTTLRSRALKAIDETRFVPAAGQTRLRSMIEGRPDWVLSRQRAWGVPICVFVDEEGNILQDDAVNKRIMDAFEKEGADAWFADGARERFLGARAGEGWTQVRDILDVWFDSGSTHTFTLEDRPDLKWPADVYLEGSDQHRGWFHSSLLESCGTRGRAPYNAVVTHGFTMDEHGKKMSKSLGNTVTPQDVIKESGADILRLWVMTTDYWEDQRLGKSIIQTNIDAYRKLRNTIRWMLGTLAHDEGENVAYADLPELERLMLHRLTELDELVRSGYDTFDFKRIARALVDFMNVELSAFYFDIRKDALYCDAPSSIRRKAALQTVREIFVRLTTWLAPMLPFTMEEAWLDRYPQSVSIHAEQFRPTPAEWRDDVLAEKWRKVRAVRRVVTGALELERADKRIGSSLEAAPVVYIADKSLSDSLEGLDFAEICITSGISVSDAAAPEGAFTLGDVKGVAVVPERAKGEKCARSWRYTTDVGADPEFPEVSARDAAALRELQALGKL
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IP2A_SOLTU
Sequence: SEGSPENRICTNNCAGYKGCNYNCDTNIASYKSVCEGEFDPKCLR
What is the function of this protein?
Inhibits trypsin strongly and chymotrypsin temporarily.
What are the official names of this protein?
Proteinase inhibitor IIA.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I20 (potato type II proteinase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZN420_BOVIN
Sequence: MAQRSVMFRDVAIDFSQEEWDCLDSAQRDLYRDVMLENYSNLVSLDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDYLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 420.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHLB_SHEB8
Sequence: MSETHLSTQRFADLPLHPEVKQALAENGFEFCTPIQALSLPVLLQSKDIAGQAQTGTGKTMAFLVATFNHLLSTPVPEGRLINQPRAIIMAPTRELAIQIAKDAILLAKHTHLKVGIVYGGESYDVQRKVLDQGVDILIGTTGRIIDYVRQGIIGLNSIQAVVLDEADRMFDLGFIKDIRFLFRRMPEANQRLNMLFSATLSMKVQELAYDHMNEPVKVEIAPEEKTSKNIKEEIFYPSQEEKMRLLLTLIEEDWPEKAIVFSNTKHSCETLWSWLEGDGHRVGLLTGDVPQKKRIRILEQFTSGQLDILVATDVAARGLHISDVSHVYNYDLPDDCEDYVHRIGRTGRAGNKGMSISFACEEYALNLPAIESYINHSIPVSNYDSEALLADIPTPAKIHRKHPSGTRNLRDRSGASRPGAQRSGARPPRHDRTRRHS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOMR_ECOLI
Sequence: MRNRWFSVMVGPSVRVNEWFSAYAMAGMAYSRVSTFSGDYLRVTDNKGRCE
What are the official names of this protein?
Putative protein LomR.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family.
Protein: INT12_DANRE
Sequence: MAGTVSLELDPIFLKGLGYLHSKSKDSAEKLKALLDESLARGSDSIYRNSIKEAEVSKVSLPKMTKQDSKSSSSSSASSSITTTSSSKSSTSEKSKKESEKRTLEKIRVDPGEGVEPPKKPRLEKQDSHSSPIAFQTKDIPIPDFTDIDETNADDFAMEMGLACVVCRQMTVTSGNQLVECQECHNLYHQECHKPQVTDKDVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPALATTVPLLKDPLVKKAELKPKPETTGSFQAFKRTEVKATAASGNSSSSSSSSSSLPPGLTGWAAFTKATSNVGPSSTKLSTSQSGNSKTSPAASGSKPVGLSALANVKPALATKPSGGSSAGSGNGNNGSGTVPLKAPPPLTLGKQVLSRSASGDSLGKMTVTGSLSPGAAPSSSLGGNGGSGGNGAGNGGNSAGSSSSSGNNNNNGAKASADGKAPTSQESQLNAMKRLQMVKKKAAQKKLKK
What is the function of this protein?
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 12, Int12.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_XANCP
Sequence: MPQVTMRQMLEAGVHFGHQTRYWNPKLAPYIFGARGKIHIINLEKTVPLFNDAMNFLSSIAQKRGTVLFLGTKRSARESIKEEAERCNMPFMTQRWLGGTLTNFRTVKQSVARLKELEAAETDGTFEKLVKHEVLGLRREREKLDASLGGIKEMNRLPDAIFVIDIGHEDIAIKEAKKLGIPVIAVVDTNYDPALVDYAIPGNDDAIRAVQLYARAAADAVLEGKAAAPNSASVREEEFSAEAGDEGKGRRAPAKKATEKKADAPAAAPEAPAAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ALKB8_HUMAN
Sequence: MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKPLSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYDQGNWCVILQKA
What is the function of this protein?
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898).  Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323).  Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323).  Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950).  Required for normal survival after DNA damage (PubMed:20308323).  May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
What are the official names of this protein?
Alkylated DNA repair protein alkB homolog 8, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein: RIMO_ALTMD
Sequence: MTVETFDPNKVANKTTTLETPVKVLSDNQSSQQGVGSRIGFVSLGCPKNLVDSERILTQLRTEGYDVVPTYNDADLVIVNTCGFIDAAVEESLDTIGEALKENGKVIVTGCLGVKEDEIRELHPNVLAITGPHAYETVVEQVHEHLPKPQHNPFADLIPDHGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPVGNVLDEAKRLKEAGVKELLVISQDTSAYGVDVKHRTGFWNGMPVKTHMQQLCEQLGEMGIWVRLHYVYPYPHVDDLIPLMNDGKILPYLDIPFQHANKRILRLMKRPGSAERVLERVKKWREQCPSLVIRSTFIVGFPGETEEEFEELLDFLREAQLDRVGAFAYSPVEGARANDLPDPVPEDIKQERLARFMEVQGEISAARLKARIGNEYQVVIDSVDAEGAVGRTYADAPEVDGLVHLNGVYDVKPGDRVWAEVIHANEHDVWAVLSEDQDDEEAHATEGAE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VMAT2_HUMAN
Sequence: MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
What is the function of this protein?
Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles.  Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis.  Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473).  Regulates the transvesicular monoaminergic gradient that determines the quantal size.  Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity).  Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity).  Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity).
What are the official names of this protein?
Synaptic vesicular amine transporter, Monoamine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Vesicular transporter family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: PTAS_BORBU
Sequence: MLYSFYKVFCLKDYVFKKARIFVKENKLKANIVFPESSDSRVLKAAIVILQKNLADSIILIGKKDTVINSLKEFSNCNDILGRIEVVDPNSFPDIEMYLDEYWSLQKLKGVTKQSLKTQVLDEITFAMLMVRFGYAKSCVCGAVSTSAKVLSNALRIIPKLEGVKIISSFMIMDTLCTARNVDFCFGHNGILFFADCSVVVNPNSLELAEIALQSAKSFKDILNAKPKVALLSFSTKGSSSAKETEKVKNALNIVRNKESDLLIDGELQLDSAIIKDVAEKKCRESLVAGSANVLIFPNLDAGNIGYKLVERFAFAKAYGPFLQGFSKPISDLSRGCSVDEIVFASALMISI
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y089_MYCSS
Sequence: MRRQEAGTSSLATRVGPEVLTTAAVASVTGCDDPLAAVLLGRPKVIEVLQRSAELIDRVPALAAAHHQIADYHAMRSRFFDAYLADAAAEGIRQCVVLAAGLDTRAFRLPWPDGMTVFEIDQPTVLRYKENALTAHGARPAADWHPVGVESDMPWPRRLWESGFNHNEPTIWLAEGLLPLPDATQDALISEIDGLSAAGSRIAFDDVLGMCSGRSDAPGWLTSRGWWTDVVEARHLPELSGRRDDDAQSYTAHAALVTAEKIA
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mmcs_0089.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: CDC73_CHICK
Sequence: MADVLSVLRQYNTQKKEIVVKGDEVIFGEFSWPKNVKTNYVIWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLAYLNGETSTSSSIDRSAPLEIGLQRSTQVKRAADEILAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFAKNIFAILQSVKAREEGRAPEQRPAPNTAPTDPTLRNKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTTVSVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
What is the function of this protein?
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways.  May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.  Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II.  PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
What are the official names of this protein?
Parafibromin, Cell division cycle protein 73 homolog.
What is the protein family that this protein belongs to?
Belongs to the CDC73 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: P5CR2_RAT
Sequence: MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEMDLPTVSALRKMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKRE
What is the function of this protein?
Housekeeping enzyme that catalyzes the last step in proline biosynthesis.  In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+).  Can utilize both NAD and NADP.  Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity).  Involved in cellular response to oxidative stress (By similarity).
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: PTH_RICRS
Sequence: MLLVIGLGNPGKEYQYTRHNVGFIAIEKIANQYNSSFSTKKKFNCEIAETISYGQKIIFIKPTTYMNLSGKSVISVKTYYNIYPAKSFVIHDDIDLETGRVKFKTGGGNGGHNGLKSIDGVIGNNYNRIRIGVGRPQNNQDLADYVLNHFSKPEYKTVMQAIDRITSNFGLILENKLEEFKNKMA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_RICTY
Sequence: MHQTNFGFNKVDYTKKQWLVNNIFSRVADKYDLMNDLMSIGLHRLWKNEFIMQIPNLNSNILDVASGSGDIALQLAKKAKARGNNISLILSDINEEMLNNAKKKSIDLNLFQNMKFIVANAEELPFLDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPMGKFICLEFSKVKEGILKDFYKFYSFTIIPSIGQIIARNKEAYEYLVESIALFPSQDDFRIMIKASGFEEVHYKNLSGGIVAIHSAYKI
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: KAD_MARN8
Sequence: MRIIMLGAPGAGKGTQAQFITERFEIPQISTGDMLRAAVKAESELGLQVKEVMASGGLVSDDIIIALIEERIQQPDCKNGFLLDGFPRTIPQAEALKDQGIAIDYVVEISVEDEEIVSRLSGRRVHEGSGRIYHVKYDPPKVEGKDDETGEALIQREDDKEETVRKRLKIYHEQTAPLVGFYQSWAEKAPADAPRYVRVEGVGSLDSIRDQILSQLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHR_BOSIN
Sequence: MDLWQLLLTLAVAGSSDAFSGSEATPAFLVRASQSLQILYPVLETNSSGNPKFTKCRSPELETFSCHWTDGANHSLQSPGSVQMFYIRRDIQEWKECPDYVSAGENSCYFNSSYTSVWTPYCIKLTSNGGIVDHKCFSVEDIVQPDPPVGLNWTLLNISLTEIHADILVKWEPPPNTDVKMGWIILEYELHYKELNETQWKMMDPLMVTSVPMYSLRLDKEYEVRVRTRQRNTEKYGKFSEVLLITFPQMNPSACEEDFQFPWFLIIMFGILGLAVTLFLLIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPANQQPSVIHVEENKPRPLLIGGTESTHQAVHHQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTSCQANFIVDNAYFCEVDAKKYIALAPHVEAESHVEPSFNQEDIYITTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP
What is the function of this protein?
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
What are the official names of this protein?
Growth hormone receptor, GH receptor, Somatotropin receptor.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH.
Protein: TRUB_LIMRD
Sequence: MDGIIPLYKERGMTSFACVSRLRQILKTKKIGHSGTLDPGVAGVLPICVGNATKVVDYLMQSGKQYQGELLIGFATTTQDLDGDKIEEKVVADEIPTSEILSAMNSLTGTIIQIPPMYSAVKVNGKKLYEYARAGETVERPKRQVTISKFELLSSKYDKKNKQQRIRFNVECSKGTYIRTLVVDLARKLGYPGVMSLLTRLKSGGFTLDQTLSLDDVRDAVATQTLQQYLYPLDYALKDYPQLTIQVAQWKKVQNGGWLSPSELNTSEKEIVLSFDGQVKALYHFDPKNKMYKPTKMFAVN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: STKLU_ARATH
Sequence: MASDQRDTDFSAESPDLEEDGGGGGGGRGGGETESDEDVVIPEPNEAEDDDHDPDPDPEYEDLNSPSMISRAPATKSSSGTVTVALPAGSAVPVASIPSDSDQKWHRMTEIVHQRPPIDDSRRLFQRLWTDEDEIELLRGFLDYITNHRGNSSHPPDTAPFYEQIKSKLQLEFNKNQLVEKLRRLKKKYRNVMSKFSSGKEVFFKSPHDQATFDISRKIWNQTGKIIGFEDNNVMDLEETNHVNNANGSSGFNVSVIGNANVDVDSENGLEKKVTISRKRSRSRIGKIDEDKPVLAPCDGVIPNAVNLNENVAVGCDFGDGRNLGVLIEETVKNCVSPMIKEMMNSTTGMMMAATGGFPGGGAHALGVLSPMLMPSMNLGFGGKGVGDERWRRQQILELEVYSRRLELVQEQIRATVNELKTMPNGG
What are the official names of this protein?
Probable transcription factor At5g28040, Storekeeper-like protein At5g28040.
What is the protein family that this protein belongs to?
Belongs to the GeBP family.
Protein: ASTE_SHIFL
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSVRHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.