PharMolix/UniProtQA huggingface dataset:
Protein: ENV_SMRVH
Sequence: MLCILILLLHPRLCPVTKGGLGKPSGDIYTALFGAPCDCKGGTQTNNYATPTYTQVTDCGDKNAYLTYDTNWNGVSSPKWLCVRKPPSIPVINGRPGPCPSECTNNIKSQMHSSCYSSFSQCTQGNNTYFTAILQRTKSTSETNPVTSGLQPHGVLQAGCDGTVGKSVCWNQQAPIHVSDGGGPQDAVRELYVQKQIELVIQSQFPKLSYHPLARSKPRGPDIDAQMLDILSATHQALNISNPSLAQNCWLCLNQGTSMPLAFPVNISSFNASQNNCTPSLPFRVQPMPSQVYPCFFKGAQNNSFDIPVGVANFVNCSSSSNHSEALCPGPGQAFVCGNNLAFTALPANWTGSCVLAALLPDIDIISGDDPVPIPTFDYIAGRQKRAVTLIPLLVGLGVSTAVATGTAGLGVAVQSYTKLSHQLINDVQALSSTINDLQDQLDSLAEVVLQNRRGLDLLTAEQGGICLALQERCCFYANKSGIVRDKIKNLQEDLEKRRKALADNLFLTGLNGLLPYLLPFLGPLFAIILFFSFAPWILRRVTALIRDQLNSLLGKPIQIHYHQLATRDLEYGRL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: NPY_TORMA
Sequence: MQTNMKFWLGVFTFAFCMLICIGTFADAYPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRYGKRSSPEALMMTDLMLRENAESFPKYRYDEPFMW
What is the function of this protein?
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
What are the official names of this protein?
Pro-neuropeptide Y.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPCHC_COLHI
Sequence: MAATKDRQLFRHLLRLSRFDRYNPLFTTFAGLWSTLLAGGAKMAEQRSDMSVATVFQQCALCFVASYLFCGAGMVWNDWIDRDIDANVARTKERPLASGKVTATEAMVWMVLQAALSWGVLEVMLDGKDVAKHFIPVAAASVLYPFGKRSLARMLGIYPQYILAFTIAWPAVIGRAAIYGQYESYAETLRQCLPLCTMVFFWTIYLNTAYSYQDVVDDRKLGVNSFYNIAGKHIHLLLVALVSPILVCLPIYLFELHSLWLWLSWMGVWTASLAQQLVQFDPKQPASGGSIHRSNFILGIWTILACVVQVFLTGSA
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable).  The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).
What are the official names of this protein?
Polyprenyl transferase dpchC, Diterpenoid pyrone biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RHMA_ECOUT
Sequence: MNALLTNPFKERLRKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASHPVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTADQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRVKGSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: RL33_HAES1
Sequence: MAAKGAREKIRLVSTAETGHFYTTTKNKRNMPEKMEIKKFDPVVRKHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RGRF1_MOUSE
Sequence: MQKAIRLNDGHVVTLGLLAQKDGTRKGYLSKRSADNPKWQTKWFALLQNLLFYFESDSSPRPSGLYLLEGSICKRAPSPKRGTSSKESGEKQQHYFTVNFSNDSQKTLELRTEDAKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKTEVTITNLIKDNDRIQSSNKAGSADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLMQMSLSEKSKSSRGRLGSLSTKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLDEPENLDDEAKGAGPEIEHLEFKIGVEPKDSLPFTVILVASTRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHNAKLLYGDAPKSPRASRKFSSPPPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGCSSDSYANIHSPISPFGKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSASRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQERKAAANIIRTLTLEETTEQHSMLEEVILMTEGVKTEPFENHPALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPKLPT
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP.
What are the official names of this protein?
Ras-specific guanine nucleotide-releasing factor 1, Ras-GRF1, CDC25Mm, Guanine nucleotide-releasing protein, GNRP, Ras-specific nucleotide exchange factor CDC25.
Protein: RPRMB_DANRE
Sequence: MNSTGFNDTDSALFSNTSFLSCCNVSSVVTDSGFVSAALDERSVFIMRTVQIAVMCVLALTVVFGIFFLGCNLLIKSEGMINFLVTDRRPSKDVEAVIVGSY
What is the function of this protein?
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle.
What are the official names of this protein?
Protein reprimo B.
What is the protein family that this protein belongs to?
Belongs to the reprimo family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein.
Protein: TRMD_BURM9
Sequence: MDEATQSAIQFDVVTLFPEMFRALTDWGITSRAVKQGRFGLRTWNPRDFTTDNYRTVDDRPYGGGPGMVMLAKPLEAAIGAAKAAQAAQGVATSRVVMMSPQGAPLTHERVARMAAEPGVVLLCGRYEAIDQRLIDRCVDEELSLGDFVLSGGELPAMALMDAVVRLLPGVLNDAQSAVQDSFADGLLDCPHYTRPEEYEGVRVPDVLLGGHHAEIERWRRQEALRNTIAKRPDLIARARREKLLSRADEAWLASLAKEAKQAS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_ECOSM
Sequence: MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKHLGRYVQKQTGADILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAVGSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQAIAEALEQEGSNHEVHVDERLRERALVPLNRMLEFAATLRG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC2_THEVB
Sequence: MTEKKPIFFNRIIDKKGLRDLIAWSFSNFGTARTAEMADKIKDLGFHYATRAGVSISVDDLLVPPKKQELLEAAEKEIKTAQERYSRGEITEVERFQKVIDTWNSTNEELKNEVVRHFRNTDVLNSVYMMAFSGARGNLSQVRQLVGMRGLMANPQGEIIDLPIKTNFREGLTVTEYIISSYGARKGLVDTALRTADSGYLTRRLVDVSQDVIIREEDCETERGITLRSMTVGDKVLALQDRLLGRVVLNDVRHPQTGEVLVAKNQAISADLAKKIVDAGIEEVVVRSPLTCEATGSVCRLCYGWSLAHARLVDMGEAVGIIAAQSIGEPGTQLTMRTFHTGGVFTGEVARQERAPFAGTVEYGKKLRVRPYRTRHGDDAFIVETAGKLVVKGGQQRQEFDLSQGSIVLVADGETVAAGQLLAEVAQAARSVRKATEKVTKDVASDLAGQVKFVNLDAEEKRDRQGTTTRIAPKGGLIWVLSGEVYNLPPGAEPVVKNGDRIEAGAVLAETTVKTEHGGVVRLPEQQDSKGGREVEIITASVMLDKAKVLKETQQGREHYIIETATGQRFSLKAAPGTKVANGQVVAELIDDRYHTTTGGILKYADIEVAKKGKAKQGYEVLKGGTLLWIPEETHEVNKDISLLMVEDNQYVEAGTEVVKDIFCQNSGVVEVIQKNDILREIIIKPGELHLVDDPEAARLKHGTLARPGEEVLPGLVVDTLSQVDYLEDTPEGPAILLRPVQEFSVPDEPSVPSQDSSDGSGQSIRLRAVQRLPYKHDERVKSVDGVDLLRTQLVLEIGSEAPQLAADIEIVTDEVDPEAQRLQLVILESLIIRRDIAADQTQGSTFTSLLVKDGDHIGPGAVIARTDIKAKQAGEVQGIVRSGESVRRILVVTDSDRLRVETNGAKPTVKVGDLVRPGDELAKGVTAPETAAVMAVADDHVILRLARPYLVSPGAVLQIEEGDLVQRGDNLALLVFERAKTGDIIQGLPRIEELLEARHPKEKCVLAVRPGTCQVTYNSDDSVEIKVIEEDGTIQEYPVLPGQNPLVVDGQKVNLADPLTDGPVDPHDILSIYFEYYKPQGLLKAAQTSLEKVQSFLVNEVQSVYLSQGIEIADKHIEVIVRQMTSKVRIDDAGDTILLSGELMTLRQAEQANEPMALTGGAPAQYTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIEGKSDWLRGLKENVIIGRLIPAGTGFNSYEESSNGDEEWEEGEDRLGQTHVISPEPESPKMTVNVTADLGEDVLIDDETAPHVIEKITGGARDFEFASSDVEEDELTEEDDDYGDEEEEDAF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: AI2_DEBHA
Sequence: MKQMSYVTRWLYSTSHKDIGMTYLGFGMLSAMMGTGMSVMMRMELSNGNSQFFHGNNQAFNVMMSGHALLMMFFFIMPVWMGAFGNFFLPMLMGAADMAFARLNNISFWCLPPALVCMVCSVLMEQGAGTGFTTYPPLSSMSAHSGPSVDLAMFAMHLTSMSSLLGAMNFMVTVLNMRTMGLHMVNMPLFAWAMFLTAMLLLLSLPVLTAAVTLLLMDRNFNTGFYEVGAGGDPVTYEHLFWFFGQWWPTNYVNNLEYCAMCWETYNKMYFIMLLITMYMSTNLLANMVKMLMTNRSNQQVTKNRMNKPHALRGDTSPKVRHKMFMNTMSKKSHALRRDTSLFSFPKNDKVRHMYDMNSKRYKSYLMGTSETTSTKSLKEMNMPSQRTGNPAITGTNLKENKNTMENSFNQWLAGLMDGDGCFGITQNKYTNCEMTVALEDEKTLRIIQNKFGGSMKLRSGAKAIRYRLHNQKGMINTMNAINGNMRHSKRLVQLHKVCSLLNMPVLEPMILTKNNSWLTGFFDADGTMNFSFKSSCHSAGGYTSKGKVSNHPQLTISVTNKYLQDVLPFKEMLGGNIYFDKSQNGYYKWSMQSKKDILNFVDYIKLNPSKTVKLNRMLLCNLYYDLKDLKSYMLNDNNMLQNKAWIKFENKWNKKF
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded endonuclease aI2.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Multi-pass membrane protein.
Protein: LOLD_BRUME
Sequence: MAAEIILRLERIGRAYKEADRELIILNDADFTLRRGEMVALVAPSGAGKSTLLHTAGLLERPDSGDVVLDGRSCSKLSDDERTAVRRNDVGFVYQFHHLLPEFSALENVMLPQMIRGLSRKAAAERAQQLLEYMKIGKRASHRPAELSGGEQQRVAIARAVANAPLVLLADEPTGNLDPTTSSYVFGALEALVRQSGLAALIATHNHELARRMDRRVTLKDGRVVDL
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL15_EXISA
Sequence: MKLHELKPTPGSRHERNRVGRGMATGNGKTSGRGHKGQKARSGGGVRPGFEGGQNPLYRRLPKRGFNNPTRKEYAVVSLDTLNRFEAGTEVTPELLIETGVVSSAKDGIKVLANGKLETKLTVKANKFSGAAKEAIEAAGGTVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RUVB_MYCBT
Sequence: MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQPGLFE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL28_PROM1
Sequence: MSRVCQLTGTRANNGMSVSHSHIRTKKLQQANLQQRRLWWEEENKWINIRVTTRALKTIQKKGLGKYAKSLGVDLNKL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RS26_STENO
Sequence: MPSKRRNNGRNKKNKGHADTVRCTNCGRVVSKDKAIKRFQQRNMVDASSKRDIQENYAYAQSDFTMPKIYVKLSYCVSCAIHARIVRVRSVEDRRHRYTTKLRQHVRPEAQTGNASLPLALLPKI
What are the official names of this protein?
40S ribosomal protein S26.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS26 family.
Protein: PGK_CORGL
Sequence: MAVKTLKDLLDEGVDGRHVIVRSDFNVPLNDDREITDKGRIIASLPTLKALSEGGAKVIVMAHLGRPKGEVNEKYSLAPVAEALSDELGQYVALAADVVGEDAHERANGLTEGDILLLENVRFDPRETSKDEAERTAFAQELAALAADNGAFVSDGFGVVHRAQTSVYDIAKLLPHYAGGLVETEISVLEKIAESPEAPYVVVLGGSKVSDKIGVIEALAAKADKIIVGGGMCYTFLAAQGHNVQQSLLQEEMKATCTDLLARFGDKIVLPVDLVAASEFNKDAEKQIVDLDSIPEGWMSLDIGPESVKNFGEVLSTAKTIFWNGPMGVFEFAAFSEGTRGIAQAIIDATAGNDAFSVVGGGDSAASVRVLGLNEDGFSHISTGGGASLEYLEGKELPGVAILAQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_PSYCK
Sequence: MSTAQSPIQTDVQHVPAKTTKSIKLVDEAQAKTNLLGMTQAQLADYFKSIGEKPFRSTQVIKWIYQQGVTDFEQMTNLSKSLRDKLSANACVIPPKVIHRQYSDDGTRKWVFEVTGGSLVETVLIPADDSKLNGRKTLCVSSQVGCALDCSFCSTGKQGFERDLTAAEILGQLWVANASYMTDENDSLENVDHSLWENNVTNVVMMGMGEPLLNYRPVVSSMELMLSDHAYGLSKRRVTLSTSGVVPKMYELAQELDVALAISLHAPNDELRNELVPINKKYPLEQLMAAARNYVFDVNPRHKKHVTIEYVMLDGVNDSNEHAEQLVALLGNLPSKINLIPFNPFPHANYDKSSNNRIHAFSNILSEAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRSAAWQQSIKDRENS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_CHLRE
Sequence: MEALVYTFLLVGTLGIIFFSIFFRDPPRMIK
What is the function of this protein?
Seems to play a role in the dimerization of PSII (By similarity).  Essential to maintain photosynthetic activity under adverse growth conditions.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: RAS1_DROAN
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKMNKPNRRFKCKML
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells.  During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
What are the official names of this protein?
Ras-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: NLAL2_ARATH
Sequence: MRPPRGGGSFRGRGGRDNGGRGRGRGRGRGRFGGGNYDEGPPSEVVEVATFLHACEGDAVFKLSNVKIPHFNAPIYLQNKTQIGRVDEIFGPINESLFSIKMREGIVATSYSQGDKFFISPEKLLPLSRFLPQPKGQSGGRGEGRVPPRGRGPPRGRGNFRGRGAPRGASRGFQPRGGPRGGFRGRGRA
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the GAR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: G1PDH_METLZ
Sequence: MEAKNNRILKDKTFDKSRWIQMPRDVIAGHDALLQLPNVITDLGVTGPLLLLSGKTTLQTVGLEVLRLLEDRQVTSAVVGEITYEEIARVEDLAQNIGAVLIIAVGGGRVIDTAKVVSYNLDIQFISVPTAASHDGIASSRASIMTADGNVSVAAHPPLAIVADTGIIAGAPHRLMAAGYADMVANYTAVMDWDLSKSKTGEQVSEYAMTLSMITAELMVENAEKIKAFDENAAWIVVKALFASGVAMSIAGSSRPASGGEHKFAHMLERLVPGKVLHGEACGVGTIISMIMHEGDWKKIRNSLRLIGAPTTPKDLGISDEIVIEAILRAKEIRPERYTIFDEDITREQAECLVARLYEE
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_XYLFM
Sequence: MRHQKSGRKFNRTDAHRGAMFSNMVASLFKYQLIKTTLPKAKELRRVAEPLITLAKVDSVANRRLAFARLRNKEAVGILFSNLGPRYITRPGGYIRLLKCGFRHGDNAPMAYVEMLERPIIAEEVT
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: IXTPA_BACCZ
Sequence: MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADSLSRQLNAIVIADDSGLIVDALNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKARFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGYDPIFYVEEYKKAMAELSSDEKNAISHRGRALRKLEEKIPEWFLGE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: ATPB2_LISMO
Sequence: MSKGQVIQVMGPVVDVKFEGGNLPEIYNALVIEYKSDAEEAPTSQLTLEVAIQLGDDVVRTIAMASTDGVQRGMEVIDTGSPITVPVGTVTLGRVFNVLGNTIDLDEPLPSDIKRNKIHREAPTFDQLATTTEILETGIKVVDLLAPYLKGGKIGLFGGAGVGKTVLIQELIHNIAQEHGGISVFAGVGERTREGNDLYFEMKDSGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDEEHQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERKLTEQGIYPAVDPLASTSRALSPDIVGEEHYAVATEVQRLLQRYKELQDIIAILGMDELSDEDKQSVSRARRVQFFLSQNFHVAEQFTGQKGSYVPVKETVKGFKDLLAGKYDHIPEDAFRSVGRIEDVLEKAKDMGVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 2, ATP synthase F1 sector subunit beta 2, F-ATPase subunit beta 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYW_PSEAE
Sequence: MTTRILTGITPTGTPHLGNYAGAIRPAILASRRSDVDSFYFLADYHALIKCDDPARIQRSRLEIAATWLAGGLDVERATFYRQSDIPEIPELTWLLTCVSAKGLLNRAHAYKAAVDRNVEAGEDPDAGVTMGLYSYPVLMAADILMFNAHKIPVGRDQVQHVEMARDIGQRFNHLFGNGREFFVLPEAVIEENVATLPGLDGRKMSKSYDNTIPLFSPSRQLKDAIARIVTDSRAPGEPKDPDSSHLFLLYSAFASAEQVAAFRQELLEGLAWGEAKQRLFQLLDNELGEARERYQALIAKPDDIEDILLAGAAKARRIATPFIAELREAVGLRSLREPLKSAESGKKKAAKAARLVSFRDDDGSFRFRLLDAAGEQLLLSRAFADGKAAGAVSKRLLAGETADLRAEGNAFGLWLDGEAVAQSPAFADAAARDAAIERTREALAPQE
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.