PharMolix/UniProtQA huggingface dataset:
Protein: YD415_YEAST
Sequence: MRIQSLFVLFNVAIIAWSYPYEPLRVLQVGENEVMEVPESEKLNLRRRGVKFFDVTKHTSFLPFFNKEEEPTVPTYNYPPEISNKEVVDDSIKNIDKGSMHKNLAKFTSFYTRYYKSDHGFESAEWLAATIANITKDIPQDTLTIEHFDHKEWKQYSIIVRVTGSTTPEDIIIIGSHQDSINLLLPSIMAAPGADDNGSGTVTNMEALRLYTENFLKRGFRPNNTVEFHFYSAEEGGLLGSLDVFTAYAKQKKHVRAMLQQDMTGYVSDPEDEHVGIVTDYTTPALTDFIKLIINSYLSIPYRDTQCGYACSDHGSATRNGFPGSFVIESEFKKTNKYIHSTMDTLDRLSLAHMAEHTKIVLGVIIELGSWSAW
What are the official names of this protein?
Probable aminopeptidase YDR415C.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
Protein: RBFA_ACTPJ
Sequence: MSREFKRSDRVAQELQKEIAVILQREVKDPRIGMVTVSDVEVSRDLAYAKIFVTFLFDNDQSVIEQGMKGLEKASPYIRSLVGKAMRLRIVPELRFIYDQSLVEGMRMSNLVSNVIKNDEAKHKEEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYR13_ECOLX
Sequence: MNPESVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTFEGDAFFPVLNAAEFEVVSSETIQGTITYTHSVYARRNG
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase type A13, Dihydrofolate reductase type XIII, DHFRXIII.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: SBT21_ARATH
Sequence: MDESSLVRFVFLLCLVSSSVFCLAESDQNATVSSAVYIVTLKDRPSVHFSGRESSDSKHSLTATSSQIYRTLNRSASIIRVHDSLLRNVLRKENYLKLYSYHYLINGFSAVLTRKQADRLAAREEVENVVLDFLVEKATTHTPQFLGLPRGAWLRDGGSEYAGEGVVIGFIDTGIDPTHPSFSDKISGHTYSVPPHFTGVCEVTIGFPPGSCNRKLIGARHFAESALSRGVLNSSQDDASPFDGEGHGTHTASVAAGNHGIPVVVAGHRLGNASGMAPRAHIAIYKALYKRFGGFAADIIAAIDQAAQDGVDIINLSITPNRRPPGIATFFNPIDMALLSAVKAGIFVVQAAGNTGPAPKSMSSFSPWIFTVGATSHDRVYSNSIILGNNVTIPGVGLASGTRIMHKLVLATHALRNGTTVMDAIYVGECQDSSSFDQKLVQGKILVCSYTVRFILGVSTIKQALLTAKNLTAAGLVFYIDPSATGFQMTSSPMDIPGILISSPQDSQALLRYYNSSLLRENGSGKIVGSASVAKIVGGMRPTYGITAPKVMYFSARGPDPEDDSFVDADIMKPNLVAPGNAIWGAWSPLGIGTNDFQGERFAMESGTSMSAPHVTGIAALIKQKFPHFTPAAIASALSTTASLSDRKGEHIMAQRTVLNPDISQSPATPFDMGSGFVNATAALDPGLIFDIGYNEYMKFLCGINGSSPVVLNYTGESCSSYNSSLAASDLNLPSVTIAKLVGTRAVLRWVTNIATTATNETYIVGWMAPDSVSVKVSPAKFTIGNGQTRVLSLVFRAMKNVSMASFGRIGLFGDRGHVVNIPVAVIYKIAV
What are the official names of this protein?
Subtilisin-like protease SBT2.1, Subtilase subfamily 2 member 1, AtSBT2.1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SAMP3_HALVD
Sequence: MELELRFFATFREVVGQKSIYWRVDDDATVGDVLRSLEAEYDGLAGRLIEDGEVKPHVNVLKNGREVVHLDGMATALDDGDAVSVFPPVAGG
What is the function of this protein?
Functions as a protein modifier covalently attached to lysine residues of substrate proteins.  The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP3 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins.  Seems to be able to form polymeric chains with itself at Lys-18, Lys-55 and Lys-62, similar to ubiquitin and other ubiquitin-like proteins.  SAMP3 appears not to serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes.  May regulate molybdenum cofactor (MoCo) biosynthesis by inhibiting the activity of MPT synthase MoaE under aerobic conditions, providing a hierarchy of oxygen use prior to that of alternative electron acceptors such as DMSO.
What are the official names of this protein?
Small archaeal modifier protein 3, SAMP3, Ubiquitin-like small archaeal modifier protein 3.
Protein: GSA_KORVE
Sequence: MSRKLDRSRELQKRAEALIPGGVNSPVRAFRAVGGEPPILVRGEGARVFDADGNGYIDYVLSWGPLILGHAFTPVINAIEKAAEKGTSFGASTPTEADLAEAVVHAMPAIEKIRFVSSGTEATMSAIRLARGFTGRKYIVKFEGCYHGHSDSLLVKAGSGVATLGIPGSAGVPDELAQLTLALPYNNVAAVEQAFTKFKGQIACVIVEPIVGNMGCVPPAADYLQALSDITKREGAVLIVDEVMTGFRVAYGGAQELYGLKPDLVTLGKIIGGGLPVAAYGGRKDIMDKIAPLGPVYQAGTLSGNPLAMAAGLAMLCHLRDNAMEIYPRLDQLSADLVNRVLDAAREAGVALTANRVGSMFTWFFTDKHVTDWDSAATCDTKQFGQFHGAMLDAGVWLPPAQFEAAFLSSAHTEQDIDDTVAAAREAFAIL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA_METM5
Sequence: MHELSYATSVLNAILDAVKQQEELGRKVIKVNDINLEIGDLTLLSVDQLQFVFEVISEDTVCKGAELKAEIVKPKIFCMDCEFEGNLDTKDELEVACPKCESRNVKLKGGKEFNIVNATIEFDDEE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: PUR9_SYNY3
Sequence: MARLALLSVSDKSGIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGGRVKTLHPRIHGGILARRDLPSDQADLEANDIRPLDLVVVNLYPFEQTIAKPGVTVAEAVEQIDIGGPAMIRATAKNFAHTTVLTNPNQYEAYLQALQEQGEIPLALRQQFAGEAFALTNAYDQAIANYFSGLSGDSANQFGLSGTLRQPLRYGENPHQSAGWYQTGREATGWAKAEKLQGKELSYNNLVDLEAARRIINEFDVREPAAVILKHTNPCGVALAPTLVEAYQKAFNADATSAFGGIVALNQPLDGPTAAAMVKTFLECIVAPGCDAEAQEILAKKNNLRVLILPDLATGPSQTIKAIAGGFLVQSADDEREDPSTWQVVTEKQPSGEELAELAFAWKVCKHVKSNAITITKNKTTLGVGAGQMNRVGSVEIALKQAGTEAQGACLASDAFFPFDDSVRTAAAAGITTIIQPGGSMRDQDSIQAANELGLVMIFTGVRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SALA_DROOR
Sequence: MKLLIALFVLVNAVIAQNGYGQGGQGPYGGQGGFGGYGGLGGQAGFGGQIGFNGQGGVGGQLGVGQGGVSPGQGGFAAQGPPNQYQPGYGSPVGSGHFHGGNPVDAGYIHGNHHEYPEHHGDHHREHHEHHGHHEHHGHHRH
What is the function of this protein?
Likely to be involved in the establishment of the head.
What are the official names of this protein?
Protein spalt-accessory.
What are the subcellular locations of this protein?
Secreted.
Protein: FUMD_ECOL6
Sequence: MGNRTKEDELYREMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTALANKRIQRSELEKQAMETVINALVK
What is the function of this protein?
In vitro catalyzes the addition of water to fumarate, forming malate.  Cannot catalyze the reverse reaction.  Cannot use the cis-isomer maleate as substrate.
What are the official names of this protein?
Fumarase D.
What is the protein family that this protein belongs to?
Belongs to the FumD family.
Protein: TSAD_SHESR
Sequence: MRVLGIETSCDETGIAVYDDKLGLLSHALYSQVKLHADYGGVVPELASRDHVRKIVPLIRQALKNANTEIADLDGIAYTKGPGLIGALLVGACVGRSLAFAWNKPAIGVHHMEGHLLAPMLEDDAPEFPFVALLVSGGHSMLVKVDGIGLYEVLGESVDDAAGEAFDKTAKLMGLDYPGGPRLAKLAAKGEPAGYQFPRPMTDRPGLDFSFSGLKTFTANTIAAEPDDEQTRANIARAFEEAVVDTLAIKCRRALKQTGYNRLVIAGGVSANTRLRETLAEMMTSIGGRVYYPRGEFCTDNGAMIAFAGLQRLKAGQQEDLAVKGQPRWPLDTLPPVA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_AROAE
Sequence: MTPLSAVATPTPAPAEAADSRFSNTFLRLKKKLERGVGKAIADFNMIGDGDTVMVCVSGGKDSYTLLSCLLALRERAPVDFRIIAMNLDQKQPGFPAEVLPAYFESIGVEYRIVTEDTYSIVKDKIPEGKTTCSLCSRLRRGIIYRVARELGATRIALGHHRDDMLETLFLNLFFGGKIKAMPPKLVSDNGEHVVIRPLAYCTEADIAKFARTMEFPIIPCNLCGSQENAQRKQIKTMLQGWAREHPGRIESIATALGQVVPSHLADASLFDFRNLTRDTLVAEGDIAFDRAELPPASAAVMPTVMQLTDHRTDGK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLP24_SCHPO
Sequence: MRVHTCYFCSGPVYPGHGIMFVRNDSKVFRFCRSKCHKNFKMKRNPRKVAWTKAYRKAHGKEMVYDTALAVTAARRNVPVRYDRNVIATTLNAMKRVSQVHAKRERLFYKKRLAGKRAQELQEAQKLIAQNVPQFTEPEGEVETAEVQEPQIVSDEEYTMEEEVAEPVKIPVLAKKRKNKKSRNSSSAMQMD
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  Ensures the docking of nog1 to pre-60S particles.  Activates and recruits ATPase afg2 to cytoplasmic pre-60S ribosomal particles.
What are the official names of this protein?
Ribosome biogenesis protein rlp24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: RUVC_DICTD
Sequence: MVVIGFDPGTAITGYGILNKGEDGISIIEYGALTTPSGWGIGRRLNYLFDQVSSLLDLYNPDVVVMENIFFNKNIKTAINIGQAQGVIILAAEQHQKEISILTPLEVKLSVVGYGRATKNQIQYMVKEILKLKDIPKPDDVADALALCISYIYKQEGC
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RSXC_ECOHS
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGRGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWADYRTRSREELIERIHQFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSNDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSANELGEPQEEQSCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAELQQTNDAATVADPRKTAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAKPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQTNAEPEEQVDPRKAAVAAAIARAQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NUOK_SULAA
Sequence: MVPYEYYVALSGLLMVLGFIGVIVRKNIIAMLISTELMLNAVNVAFVAFDMKLHDVVGQVFVFFILTIAAAEAAIGLGLIMAIYRMKKDVDVEKLTELKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TATD_CROS8
Sequence: MFDIGLNITSSQFDHDRDEMIARARAAGVSNMLFTGTSLEESEKACAFARRYEGCWSTAGVHPHDASTWNDESAARLRALAGEAQVVAIGECGLDFNRNFSTPAEQEHAFTEQLRLAAELALPVFLHCRDAHARFLALLDPWLDKLPGAVLHCFTGTEQEARETMARGLYLGITGWVCDERRGLELRALLPVIPADRLLLETDAPYLLPRDLAPRPKSRRNEPCWLPHILKQVAQWRGEDPAWLEATTDANAARLFLKNASPA
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_STRTD
Sequence: MANVKLFDQTGKEVSTVELNDAIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVEALSFAAPKTAEFANVLSALSIDSKVLVIVEEGNKFAELSARNLANVTVATPATASVLDIVNADKLLVTKEAISSIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: YOAI_ECOLI
Sequence: MNDQMFVETLIITSSFFAIAVVLVLSVLLIERTG
What are the official names of this protein?
Uncharacterized protein YoaI.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SLYX_MARN8
Sequence: MSKNSLEERLAELEMRLAFQDELINTLSDQVAKQEMDIRELWDAKKMLHKQLKDISPSNIRREEEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RL7_HELP2
Sequence: MAISKEEVLEYIGSLSVLELAELVKMFEEKFGVSATPTVVAGAAVAGGAAAESEEKTEFNVILADSGAEKIKVIKVVREITGLGLKEAKDATEKTPHVLKEGVNKEEAETIKKKLEEVGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y2055_SHEWM
Sequence: MNLSLHEARIIGCLLEKEVTTPDQYPLSLNSLTLACNQKSSRDPVMSMTESETQSAIDSLMKKRLVTDQTGFGSRVTKYKHRFCNTEFSDLQFSPAQFALICLLLLRGPQTPGELKSRSGRLHQFADLNEVENALLALAQREPSLVHQLPKEPGRRDSRFEELISDQVKGESVPISEHSRSQREAPSKRQDEMDELTLRVSQLELEVKTLKEALQDLLD
What are the official names of this protein?
UPF0502 protein Swoo_2055.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: CH60_STRPC
Sequence: MNMAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLKTNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAKITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNATRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVVIDKLKNSPAGTGFNAATGEWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMMGGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBHB_ASPFU
Sequence: MLASTFSYRMYKTALILAALLGSGQAQQVGTSQAEVHPSMTWQSCTAGGSCTTNNGKVVIDANWRWVHKVGDYTNCYTGNTWDTTICPDDATCASNCALEGANYESTYGVTASGNSLRLNFVTTSQQKNIGSRLYMMKDDSTYEMFKLLNQEFTFDVDVSNLPCGLNGALYFVAMDADGGMSKYPTNKAGAKYGTGYCDSQCPRDLKFINGQANVEGWQPSSNDANAGTGNHGSCCAEMDIWEANSISTAFTPHPCDTPGQVMCTGDACGGTYSSDRYGGTCDPDGCDFNSFRQGNKTFYGPGMTVDTKSKFTVVTQFITDDGTSSGTLKEIKRFYVQNGKVIPNSESTWTGVSGNSITTEYCTAQKSLFQDQNVFEKHGGLEGMGAALAQGMVLVMSLWDDHSANMLWLDSNYPTTASSTTPGVARGTCDISSGVPADVEANHPDAYVVYSNIKVGPIGSTFNSGGSNPGGGTTTTTTTQPTTTTTTAGNPGGTGVAQHYGQCGGIGWTGPTTCASPYTCQKLNDYYSQCL
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase B, Beta-glucancellobiohydrolase B, Exocellobiohydrolase B, Exoglucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIUH_MUSDO
Sequence: NKPSLSIVNPLDVLRQRLLLEIARRQMKENTRQVELNRAILKNV
What is the function of this protein?
Regulation of fluid secretion.  Stimulates primary urine secretion by Malpighian tubules and causes a dose-dependent stimulation of cAMP levels in the tubules.  May act as clearance peptide in that it may remove metabolic waste from the hemolymph.
What are the official names of this protein?
Diuretic hormone, DH, Diuretic peptide, DP.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATG4_KLULA
Sequence: MEFLSRISQHLGIVEDVDRDGTVFILGKEYAPLNNKSRTDVETDDSALESLINIVSLNPGLLSDVHSRVFFTYRTQFTPIRRNENGPSPINFTLFFRDNPINTLENALTDPDSFYSDIGWGCMIRTGQALLANAIQRVKLAREFRINASRIDDNELNLIRWFQDDVKYPLSLHNFVKAEEKISGMKPGQWFGPSATARSIKTLIEGFPLCGIKNCIISTQSADIYEDEVTRIFHKDRDANLLLLFAVRLGVDKINSLYWKDIFKILSSPYSVGIAGGKPSSSLYFFGYQNENLFYLDPHNTQQSSLMMDDLEFYRSCHGHKFNKLHISETDPSMLLGMLISGKNEWDQFHTYFRDSQIIQFLTTRPENDLYQSANMSVGSDSIHSLESDIQDTGEYVDVGTLVSGKQMSSPQPKDEEFEDVKCKSQRIIVCEDPADPEVEQVLVEDSSSC
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: RHLB_TOLAT
Sequence: MSKTHLTEITFAELGLEPQVLAGVEAKGFHNCTPIQAETIPLLLTGKNIAGQAQTGTGKTIAFLAGTFNYLLTHSASAERRQNQPRVLIMAPTRELAVQIYNDAVPMSESCGFKMGLAYGGDGYDKQLAVLQEGVDLLIGTTGRIIDYLKQGIIDLGAIQVVVLDEADRMFDLGFIKDIRFLFRRMPPPAQRLNMLFSATLSLRVQELAYEHMNEPQHIQIEPEQMTGQRIKEELFYPSNEDKMLLLLTLMEEDWPEKAIIFANTKHGCEDVHAWLQADGHRVGLLTGDVPQKKRLKILEDFTAGLLDVLVATDVAARGLHIPDVSHVFNYDLPDDAEDYVHRIGRTGRAGRSGHAISFACEDYAFNLPEIEEYTHHPIPVSKYDPSALLDDVTAPKRVVRHRLPVNRNMRDRQSTGRRRPGNKS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_GEOTN
Sequence: MTHIRFDYSKALAFFGEHELTYLRDAVKVAHHSLHEKTGVGNDFLGWLDWPVNYDKEEFARIKQAAKKIQSDSDVLLVIGIGGSYLGARAAIEMLHHSFYNALPKEKRSTPQIIFVGNNISSTYMKDVIDFLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEDKYGKEEARRRIYATTDRARGALRTLADEEGYETFVIPDDIGGRYSVLTAVGLLPIAASGADIDAMMEGAAKAREDFSRSELEENAAYQYAAIRNILYNKGKTIELLVNYEPALHYFAEWWKQLFGESEGKDQKGIYPASADFSTDLHSLGQYIQEGRRDLFETVLKLEEPRHELVIEAEESDLDGLNYLAGQTVDFVNTKAFEGTLLAHTDGGVPNLVVTLPKLDEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEELKDELEKRLK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFCN_ECO57
Sequence: MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKVSEVPVKRLIQEQVDASHYFSDEFQPLLNADGPVKYVRPGVDHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: ANFC3_TAKRU
Sequence: MSLNLPGYALFFILLVASSGAKPAPDLQILEPPLSSLEEQEEMQEEVQEKVQEQQEEVQEKVQEQQEEVQEQQEEVQEQQEEQQEEVQERGRGTGDVLLRAQLDSSTWALQKDDVLMRLFKDLLRTSKRSRSRYKKGGLRSCFGVRLARIGSFSGLGC
What is the function of this protein?
Exhibits natriuretic and vasodepressant activity.  Has cGMP-stimulating activity.  May help to regulate body fluid homeostasis in a variety of aquatic environments.
What are the official names of this protein?
C-type natriuretic peptide 3.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.