PharMolix/UniProtQA huggingface dataset:
Protein: AAEX_SALHS
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRMLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS17_YERE8
Sequence: MTDQIRTLQGRVVSDKMEKSMVVAIERVVKHPIYGKFIRRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAIL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RS3A_UNCRE
Sequence: MAVGKNKRLSKGKKGLKKRAQDPFSRKDEYLVKAPSTFATRDVGKTIVNRTVGLKNANDSLKGRIFEVSLADLQNDQAHSFRKIKLRVDEVQGKNCLTNFHGMDFTSDKLRSLVRKWQSLIEANVTVKTTDDYLVRLFAIAFTKRRSFQVKKTTYARSSQIRAIRKKMVEIIQREASTRTLTQLTKLVPEVIGREIEKATRGIYPLQNVHIRKVKLLKQPKFDIGALLALHGESSTDDKGQKVEREFKEQVLESV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_ROSS1
Sequence: MMNQDTLPNLYDLSLAEMERLMTAWGQPAYRARQIFRQLYVNLVDSPLAMTDLPLALRERLVAETRLAPLAPEQVHVADQGLTRKALFRLENGVLIESVLMIYPDRATVCVSTQAGCGMGCVFCATGTLGLLRNLSPGDIVAQVVWAAREMRRFAAERCISPSLAPPDDDSWWTPDTLEDQGSSEARSISVSRLSNIVFMGMGEPFANYDRWWRAVEILHDPRGLNMGARSMTVSTVGLIPGIRRLATETLPINLAISLHAPDDALRSALMPVNRRYPLAALLEATRDYLAATGRRVSFEYVLLQGKNDEPEHAAKLAALLHGEAGTTPLPLHLVHVNLIPWNPVPGMPLGRSERRRVLTFQRILRERGIACTVRVERGVSIAAACGQLAGARGLNVEC
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_MOOTA
Sequence: MRIEEFDYELPPGQIAQQPVEPRDASRLLVLHREGGFLEHRHFYDLPRYLHPGDVLVVNETKVIPARLWGYRAGTGAKIEVLLLTRQEGDTWETLVRPGRRVPVGAELIFGRGELQARVKGVTPAGGRIMEFSYQEGPWEALLERLGEMPLPPYIKEKPADPGRYQTVYAREEGSAAAPTAGLHFTPRLLKELREQGIEIASILLHVGLGTFRPVKVENIQEHVMHAEYYAVTPAAAATINAARARGHRVVAVGTTVVRTLETVATADGVIHAGSGWTDIFIYPGYRFKAIDSLITNFHLPRSTLLMLVSAFAGREKILDAYRVAVREGYRFYSFGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC61G_XENLA
Sequence: MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGS
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity).  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity).
What are the official names of this protein?
Protein transport protein Sec61 subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RHAB_ECOL6
Sequence: MTFRNCVAVDLGASSGRVMLARYERECRSLTLREIHRFNNGLHSQNGYVTWNVDSLESAIRLGLNKVCEEGIRIDSIGIDTWGVDFVLLDQQGQRVGLPVAYRDSRTNGLMAQAQQQLGKRDIYQRSGIQFLPFNTIYQLRALTEQQPELIPHIAHALLIPDYFSYRLTGKMNWEYTNATTTQLVNINSDDWDESLLAWSGANKAWFGRPTHPGNVIGHWICPQGNEIPVVAVASHDTASAVIASPLNGSRAAYLSSGTWSLMGFESQTPFTNDTALAANITNEGGAEGRYRVLKNIMGLWLLQRVLQERQINDLPALIAATQALPACRFIINPNDDRFINPDEMCSEIQAACRETAQPIPESDAELARCIFDSLALLYADVLHELAQLRGEDFSQLHIVGGGCQNTLLNQLCADACGIRVIAGPVEASTLGNIGIQLMTLDELNNVDDFRQVVSTTANLTTFTPNPDSEIAHYVAQIHSTRQTKELCA
What is the function of this protein?
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose).  Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
What are the official names of this protein?
Rhamnulokinase, RhaB, ATP:L-rhamnulose phosphotransferase, L-rhamnulose 1-kinase, Rhamnulose kinase.
What is the protein family that this protein belongs to?
Belongs to the rhamnulokinase family.
Protein: EFTU_PROM1
Sequence: MAREKFERNKPHVNIGTIGHVDHGKTTLTAAITKVLAKKGQAEAQDYAEIDGAPEERERGITINTAHVEYETDGRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGAMAQTKEHILLAKQVGVPALVVALNKCDMVDDEEMIELVEMEIRELLTSYDFPGDDIPVVQVSGLKAIEGEADWETKIDDLMTAVDASIPEPEREIDKPFLMAVEDVFSITGRGTVATGRIERGKVTVGEEVEIVGIRDTRLTTVTGVEMFRKLLDEGMAGDNVGLLLRGIQKEDIERGMVLVKKGSITPHTKFEGEVYVLKKEEGGRHTPFFAGYRPQFYIRTTDVTGQITAFTSDDGSNVEMVMPGDRIKMTGELIAPVAIEQGMRFAIREGGRTIGAGVVSKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_SHEFN
Sequence: MKFVDEANIRVEAGDGGSGCVSFRREKYVPDGGPDGGDGGDGGSVYLQANENLNTLIDYRFTRFHMAERGTNGRGRDCTGHGGSDLVLQVPVGTRAIDQETEESLGDLTVNGQKLLVAKGGFHGLGNTRFKSSTNRAPRQKTLGTPGEVRSIKLELLLLADVGLLGMPNAGKSTFIRSVSRATPKVADYPFTTLVPNLGVVNPRPGQSFVIADIPGLIEGAAEGAGLGIRFLKHLERCRMLLHIIDIEPIDGVDPVYSARAIVGELEKYSPKLAAKPRWLVFNKTDLLLDEEIQAKIDRIVKELDWQGDVYTMSAYNRTGTEELSIKMLDYIRSLPAIVEEITADADVEFKWDNYHSAEDENANENYDDDFDEDFDDDDYDVEVIYQR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1751_HELHP
Sequence: MNSRHKGTQAEDFACVFLRECGFEILERNFFARYGEIDIIALKDNVVHFIEVKSGESFEPIYNITPSKIKKLTKAIGFYLFTHKITQAYCLDALIIKNGECELIENITLC
What are the official names of this protein?
UPF0102 protein HH_1751.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: NANE_ECOSE
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: CISY_ACIAN
Sequence: MSEATGKKAVLHLDGKEIELPIYSGTLGPDVIDVKDVLASGHFTFDPGFMATASCESKITFIDGDKGILLHRGYPIDQLATQADYLETCYLLLNGELPTAEQKVEFDAKVRAHTMVHDQVSRFFNGFRRDAHPMAIMVGVVGALSAFYHNNLDIEDINHREITAIRLIAKIPTLAAWSYKYTVGQPFIYPRNDLNYAENFLHMMFATPADRDYKVNPVLARAMDRIFTLHADHEQNASTSTVRLAGSTGANPYACISAGISALWGPAHGGANEAVLKMLDEIGSVENVAEFMEKVKRKEVKLMGFGHRVYKNFDPRAKVMKQTCDEVLEALGINDPQLALAMELERIALNDPYFVERKLYPNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEMHSGPYKIGRPRQLYTGEVQRDIKR
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: CEP44_RAT
Sequence: MATGDLKRSLRKLEQVLRSLNYPNEVDYVGLMKGDTAASLPIISYSLTSYSPHVAELLMESNIELIAKNDVRFTDTVYKLLRDQFDYKPILTKKQFIQSGFAEWKIEIVCDILNCVMKKHKKLIGLDKNSSCQRKKSISEKPEPCSSREKCPAEAVGIDVTGRFMTSGKKKAVVIRHLYTEENVGVPEGTVTSTEVSEGCDELEEQSSDIRIPEAQAPEVKAELQDMCDNPELTALQIALAECQEKLKKLTWIEKRLECLEATTKGKVMVDEKAWNNILSRVTLLETEMLLSKKNESVEPNTTSEDSESVSGVDVVPYDKKYSVEGPASTCHSSGYSTVSSATVPRSSTINYCGLNNFSEETTMQKMERMKKMFEETAELLKCSSR
What is the function of this protein?
Centriole-enriched microtubule-binding protein involved in centriole biogenesis.  In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall.  Functions as a linker component that maintains centrosome cohesion.  Associates with CROCC and regulates its stability and localization to the centrosome.
What are the official names of this protein?
Centrosomal protein of 44 kDa, Cep44.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Localizes to the proximal end of mother and daughter centrioles.
Protein: YHAM_ALKCK
Sequence: MAKGIRHHRVGEAVDGYLLIKTATKQIASNSKPFLTLILGDHTGEIEAKLWGISPEDEATFVNKTIVHIQGDVIDYRGRLQLKIASIRPTSAMDGVHLNDFVRSAPLAPNDMLDEVNQYIFEIHNPHIQRITRFLLKKHQQAFLESPAATKNHHEFMSGLAFHVVSMLRIGKSLIELYPTLDKDLLYAGIILHDLGKVRELSGAIDTTYTLEGKLLGHISIMSNEIAQAAKELEIDGEEVLILQHLILSHHGKGEWGSPKTPVVREAEVLHLIDNIDAKINMMDRALERVQPGEFSERVMALDNRSFYKPSFHKKPIEL
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: NADK_RICFE
Sequence: MNINKIALIYNQNSKHLAIIEEIKKLYNYCKIEEAEAIIVIGGDGELLHNIHRYMNLNIPFYGVNLGSLGFLMNPLDTKNLLQNIHESTVSILNPLLMQAEDISGQIYTALAINEVSIFRKTNQAAKFRIDVNGIERMSELVADGALVATPAGSSAYNLSAGGPILPLDSNMLCLTPICSFRPRRWHGALLLSSATIKFEILNTNKRPVNATADFQEFNNITNVTVKSTKDKPIKLLFNKNHTLEDRIIKEQFGG
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATN1_MOUSE
Sequence: MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARIEEPSAPKASKQGRSEEISESESEETSAPKKTKTEQELPRPQSPSDLDSLDGRSINDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPPPPDSTPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPTHPQLYPGNASGGVLSGPPMGPKGGAAASSVGAPSGGKQHPPPTTPIPISSSGASGAPPAKPPSAPVGGGSLPSAPPPASFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSPHAMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSSSSSAAASSSSSSSSASQYPASQALPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANNNTHPGPFPPTGGQSTAHPAAPTHHHHQQQPQQQHHHGNSGPPPPGAYPHPLESSNSHHAHPYNMSPSLGSLRPYPPGPAHLPPPHGQVSYNQAGPNGPPVSSSNSSGSSSQASYSCSHPSSSQGPQGASYPFPPVPPVTTSSATLSTVIATVASSPAGYKTASPPGPPQYSKRAPSPGSYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYEPPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
What is the function of this protein?
Transcriptional corepressor.  Corepressor of MTG8 transcriptional repression.  Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity).  Recruits NR2E1 to repress transcription.  Promotes vascular smooth cell (VSMC) migration and orientation.
What are the official names of this protein?
Atrophin-1, Dentatorubral-pallidoluysian atrophy protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell junction. Nucleus. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity).
Protein: RIMM_SYNPW
Sequence: MTADDWLPVGKVVAVQGLKGELRVNPASDFPERFTEPGSRWLKARGQAPREIELTSGRQLPGKSVFVVRFAGVESRDAAEALVGQTLMVPADDRPELAEGEFHLLDLVGLEARLSADGDAIGTVKDLISGGNDLLVLERPDGRTLMIPFVEAIVPDVHLEQGWLRLTPPPGLLEL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4X_MOUSE
Sequence: MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
40S ribosomal protein S4, X isoform.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: D108B_PANTR
Sequence: RGKFKEICERPDGSCRDFCLETEIHVGRCLNSRPCCLPLGHQPRIESTTPKKD
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 108B, Beta-defensin 8, BD-8, DEFB-8, cBD-8, Defensin, beta 108, Defensin, beta 108B.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLU_EMENI
Sequence: MAQTNGEMEHSKESPEQITNGNNQEVVQEDDGAGGLFQISVKLPHEPYKIQVMVSSQEQVQDVRQSIVELPGTFQYTCFHLEFNGKRINDFVELSEVPGLQADSEIVLVEDPYTEKDARMHVVRLRELLGAAGDRVDTINGVNAGLSLHDSIAAEAGSEKSEKEHSLAKYDIPGSSSLKTILPRSEAPAPKTVKSISLSPWNPPPHHLRQKGHLLYLQVTTNEGEQFQITSHVSGFFVNKCSNSRFDPFPKTIPKKGSAHSLLNLISQLSPSFDAAFKELQESNNQKDLLTTFPFQNSIPSSPWLVAPPASNSLQTTKELPRETVQDRVFRERLTSKLFADYNEAAARGAVLVARGEVAPLNPTEAQDAQIFVYNNIFYSFGADGVGTFASEGGDEAARVAVGKDVLGIKAVNQLDINGLFTPGTIVVDYMGKRIVGQSIVPGIFKQREPGEHQIDYGGVEGKDVVATHPDFVPVFEKLSKALRIKKHPVWDKDNQRHDLEGSVETKGLLGTDGRKYVLDLYRVTPLDVAWNEEEDGDAYPHRMSVLRLELVESYWRAKMSQYVKAEVERRRAAKAEEAAKKEKSSEDTESKEEGSEEKSEEALDQERVDISGFSLALNPDVFSGQIPQTDEEKEQWAQDEKEVRDACDFLRSKVMPELIQDLHDGDVGFPMDGQSLSQLLHKRGINIRYLGKLATLAKEKGSRLEALSTLLVQEMVVRAFKHITNKYLRNVPAPFAASCVAHLLNCLLGADVNATPRAEIDSSLREIYPEGDFSFEKVTPEALRAEIEKQVTLRYRFNLESQWFNSLRHLQLLRDIAIKLGLQLAARDFVFTKAQAEGLKVLPVANGVNGTGQDEGSKKKKKNKNGDSGSPARSAAAEKPIVTFTPDDIVNIVPLVKDASPRSSLAEEALEAGRISLMQNQKQLGQELILESLSLHEQIYGILHPEVAKLYHQLSMLYYQTDEKDAAVELARKAVIVTERTLGVDSADTILSYLNLSLFEHASGNTKVALAYIKHAMDLWKIIFGSNHPDSITTMNNAAVMLQHLKQYSDSRKWFEASLSVCESLFGKQSINTATILFQLAQALALDQDSKAAVGKMRDAYNIFLSQLGPEDRNTKEAETWLEQLTQNAVSIAKHAKDIQARRLRRINMGTRTTLGTQIQPQVGQSTADVSAPSQASNSSIDSRNIDELLKFIEGGDTSSSRTKQKKRAAASNPKLRGSKKSSA
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Clustered mitochondria protein homolog, Protein TIF31 homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NARO_HALVD
Sequence: MNEGVHGEIHVADPSICRVSEASKETAVESVSRSVGATGDTAAVEFTAPSSAAIDDADEIFHHEQKTIYRVTHSFTEESRCACELIEGHGCPVRHLEADCGAVVLSFVAADLESFRDIVVNLKSAFDGVSLRRLTQSEPDSATGSLVFVDRDELTARQREVLETAHEMGYFEHPREANATEVAAALDINRSTFTEHLSAAQSKLLDTILDV
What is the function of this protein?
Activates transcription of the denitrifying genes (nitrate reductase narA and nitrite reductase nirK) under anaerobic conditions.
What are the official names of this protein?
Transcriptional regulator NarO, Bacterioopsin transcriptional activator, DNA-binding protein NarO.
Protein: AT132_MOUSE
Sequence: MSADSSLLMGSTPPSYGTLTTGTSIDPLSSSASSVRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEIKDKEGSSRQLFTVQVQTEAVVQGSLELPPQAQAEDGRSQAAVGVTPEGTWQDTSELHRQEEAKQVLRYYVLQGQRYVWMETQQAFCQVSLLDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEGPKPYCPETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLPLVPEPCHLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEGPAAGSAPGSQVLVVMRPPPGGPRQQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPSDFSQVLQSYTAAGYRVVALAGKPLPIAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEHLAVIHATHPEQGQPAALEFLPTESSAVMNGAKATGYPTVPEPQSCHLALSGSTFAVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVVFSLSGFQYLILAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGLILVPGLLQGPLGLRNIVDSSFKLLLLGLVAFNFVGAFMLESVLDQCLPACLRWLRPKRASKKQFKRLQQELAEHPWPTLPVGSVR
What is the function of this protein?
ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (By similarity).  Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (By similarity).  Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (By similarity).  Contributes to cellular zinc homeostasis (By similarity).  Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (By similarity).  Required for proper lysosomal and mitochondrial maintenance (By similarity).  Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822).  Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141).  Promotes secretion of exosomes as well as secretion of SCNA via exosomes (By similarity).  Plays a role in lipid homeostasis (By similarity).
What are the official names of this protein?
Polyamine-transporting ATPase 13A2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Protein: LIPT_BOVIN
Sequence: MLIPFSMKNCFQLLCNLKVPAAGFKNTVKSGLILQSISNDVYHNLAVEDWIHDHMNLEGKPVLFLWRNSPTVVIGRHQNPWQECNLNLMREEGVKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMENLKLVVRALKAVHPHLDVQATKRFDLLLDGQFKISGTASKIGRNAAYHHCTLLCGTDGTFLSSLLKSPYQGIRSNATASTPALVKNLMEKDPTLTCEVVINAVATEYATSHQIDNHIHLINPTDETVFPGINSKAIELQTWEWIYGKTPKFSVDTSFTVLHEQSHVEIKVFIDVKNGRIEVCNIEAPDHWLPLEICDQLNSSLIGSKFSPIETTVLTSILHRTYPGDDELHSKWNILCEKIKGIM
What is the function of this protein?
Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoyltransferase 1, mitochondrial, Lipoate biosynthesis protein, Lipoate-protein ligase, Lipoyl ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ACHB_BOVIN
Sequence: MTPGALLLLLLGVLGAHLAPGARGSEAEGRLREKLFSGYDSTVRPAREVGDRVWVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPEEHEGIDSLRISAESVWLPDVVLLNNNDGNFDVALDINVVVSSDGSMRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLSPEGQERQEVYIHEGTFIENGQWEIIHKPSRLIQPSVDPRGGGEGRREEVTFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLGLKRPKPERDQMQEPPSIAPRDSPGSGWGRGTDEYFIRKPPNDFLFPKPNRFQPELSAPDLRRFIDGPNRAVGLPPELREVVSSISYIARQLQEQEDHDVLKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYHLPPADPFP
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: COBQ_CUPPJ
Sequence: MVQGTTSDAGKSTVVAGLCRVLARAGMRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAARVEPHTDMNPVLLKPSSDTGAQIIIHGKARLDLDARAYHAYKPEAMKAVLASHERLTQAYDVVVVEGAGSPAEINLRDRDIANMGFAERVDCPVVLVADIDRGGVFAHLVGTLDCLSDSERARVTGFIINRFRGDISLLQPGLDWLEARTGKPVFGVLPYLHGLHLDAEDAIVGAQSAKRGTPDALLRVIVPVLPRISNHTDFDALRAHPQVDLRFIGPGMPVPPADLVILPGSKSVRADLDFLRANGWEPALRRHLRYGGKVIGICGGMQMLGRQIHDPAGHEGPAGSSAGFGWLDYETTLAPHKQLRRVSGRLADADREAAVSGYEIHMGVSTGSGLERPALWLDDENGTRRADGACSEDGQVLATYVHGVFDEPTACEGLLRWAGLDGAQGIDLAALREASIERLADTLASHLDLGAMFAPLRR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.