PharMolix/UniProtQA huggingface dataset:
Protein: CAPR1_RAT
Sequence: MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPIVEDQVAEAEPEPTEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWAVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHAAEQRPQKEPIDQIQATISLNTEQTTASSSLPAASQPQVFQAGASKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQSQYQASYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQSTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRSSFSNTPNSGYTQSQFNAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
What is the function of this protein?
mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:15858068, PubMed:20516077).  Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity).  Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity).  In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity).  Binds directly and selectively to MYC and CCND2 mRNAs (By similarity).  In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).
What are the official names of this protein?
Caprin-1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored protein p137, GPI-p137, p137GPI, RNA granule protein 105.
What is the protein family that this protein belongs to?
Belongs to the caprin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, dendrite. Cell projection, lamellipodium. Note=Associated with RNA granules (By similarity). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity).
Protein: LOLD_LEGPA
Sequence: MNDIILTSQKLYKSYHDGTSRVEVLKGVDLAITKGDRIAIIGPSGSGKSTLLHLLGGLDKPTSGLITLGKVDWQKINEKQRCQLRNQQLGFVYQFHHLLPEFTALENVMMPLLLAGMAVKDAEEKAINMLEQVGLKPRLAHKPAQLSGGERQRVAIARALVHQPHCVLADEPTGNLDEATASKVFDLMLELNKKMNTALVIVTHDQRIAERMDRVLVLHEGSLYARE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YBEY_XANOR
Sequence: MTKGPIRLDVAVSYALPRAGLPSAVSFRKWVAAALKGRIREADLAVRLVDEKEGCSLNHHYRGKDYATNVLSFPAELPEGLPKGIKMPLLGDLVICAPVVAREAAEQGKSLAAHYAHLTVHGTLHLLGWDHDDDKEADAMEQLEREILADLGIDDPYAGEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_ACIET
Sequence: MARLQEIYRDKIAPELVKQFGYTSPMQVPRLTKITLNMGVSEAVADKKIMDNAVADLTKIAGQKPVVTKAKKAIAGFKIREGQAIGCMVTLRGAQMYEFLDRFVTIALPRVRDFRGISGRAFDGRGNYNIGVKEQIIFPEIEYDKVDALRGLNISITTTAKTDEEAKALLTAFRFPFKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NUOK_ECOK1
Sequence: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_OLEA2
Sequence: MTQEFNYGTGRRKTATARTRLYSGTGKIVVNGRPYDEYFPRKSLQMIIRQPLALTKNVESFDIHVNVQGGGVRGQAEAVRHGISRALLEVDVEMRSSLKRAGFLTRDARKKERKKYGQRAARARFQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: TRPB_RUEST
Sequence: MAEDLINSFMNGPDENGRFGIFGGRFVSETLMPLILSLEEEYEKAKVDPDFWAEMDDLWKNYVGRPSPLYFAERLTNHLGGAKVYMKRDELNHTGAHKVNNVLGQILLARRMGKTRIIAETGAGQHGVATATVCAKFGLKCVVYMGAHDVRRQAPNVFRMRLLGAEVIPVTSGRGTLKDAMNDALRDWVTNVRDTFYCIGTVAGPHPYPAMVRDFQSVIGKEVRWQLAEQEGEGRLPDTVIAAIGGGSNAMGLFHPFLDDPSVNIIGVEAGGKGVDEKMEHCASLTGGRPGVLHGNRTYLLQDDDGQILEGFSISAGLDYPGIGPEHAWLHETGRAQYVSITDKEALEAFQLSCAMEGIIPALEPSHALAHVTKIAPELPKDHIIVMNMCGRGDKDIFTVARHLGFDMSDTEEGRDLEE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HBB_PERCR
Sequence: VHLTDAEKALVTGLWGKVKPDELGGEALGRLLGVYPWTQRFFDSFGDLSSASALMSNAKVKAHGKKVLDSFSEGLKHLDNLKGTFASLSELHCDKLHVDPENFKLLGNMLVLVMAHHLGKDFTPAAQAAYQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TRPC1_MOUSE
Sequence: MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
What is the function of this protein?
Thought to form a receptor-activated non-selective calcium permeant cation channel.  Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.  Seems to be also activated by intracellular calcium store depletion.
What are the official names of this protein?
Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1, mTrp1, Trp-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SURE_THEGJ
Sequence: MRILLTNDDGIYSNGLRAAVKALSELGEVYVVAPLFQRSASGRAMTLHRPIRAKRVDVPGARIAYGIDGTPTDCVIFAIARFGSFDLAVSGINLGENLSTEITVSGTASAAIEASTHGIPSIAVSLEVDWKKTLGEGEGVDFSVSAHFLRRIAGAVLERGLPEGVDMLNVNVPSDATEDTKMAITRLARKRYSPTVEERIDPKGNPYYWIVGRLVQDFEPGTDAYALKVERKVSVTPINIDMTARVDFEKLKNVLFGESLQTGRTY
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TZ72_CHIGU
Sequence: MKTVLHIAIFSAVVVAICGVRQNYGNVRYNYTELPNGEYCYIPRRRCDTTEQCCKPYDTINNFAACGKAWPEDKKRKVNKCYICDNELTLCTR
What is the function of this protein?
Probable neurotoxin with ion channel impairing activity.
What are the official names of this protein?
U36-theraphotoxin-Cg1a, U36-TRTX-Cg1a, Jingzhaotoxin-72, JZTX-72.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 27 (Jztx-72) family. ICK-72 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LTOR4_PONAB
Sequence: MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR4, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR4 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RS12_CUPMC
Sequence: MPTINQLVRKPRVSEVIKSKSPALENCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGSLDLQGVKDRRQARSKYGAKRPKAA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: URED_RHIEC
Sequence: MTIVATATRPQRAEGRGHLAAKLLDGRTRIRELYQEGAAKIRLPNTFDASMEAVIINTAGGLTGGDRMDWSVVAGAGTKIDVTTQACEKIYKASAGVAEVTTRIEAGAGARVDWLPQETILFDRAALFRRLDVDLDESAEFLAVEAVLLGRKAMGETVDTGLFRDRWRIRRSGRLIHAEELRFSEGVAALSARQAVLGGQVAFATLLYAGPLAEAYLGRVRSLLEGAMGGASAWGDKLVVRLAAADGFTLRKILIPVISVLRNGAPVPKVWNL
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAA_DICNV
Sequence: MSYFTREKHELTAATPWEKTVAKMLSPFNRFMNSANGSGILLVFLTIVALVFANTSCREWYERVLNQQLLVQMGSFKIDMTIHYWINDALMTLFFLMVGLEIKYEMKVGRLASLKRAVLPIFAALGGMIVPALIYFSFNSQGETVSGWGIPMATDIAFAIAILLLLKGKVSPSLTAVLVALAIVDDLGAVIVIAIFYTDNLAWSPLIAAFLCFAVLLLLNRGGIRALWAYIAIGSLMWVFMLFSGVHATVAGVLTALATPMNAVYSPTEFSTQARQLLDEFDAHPDSKTQVAHSRELNDLLQQLSTGIQKTQTPLQRLEHILNTPVYFLIVPLFVLFNAGVHVELNNLNALLHSPVLKGVFFGLVFGKLIGVVSAIMICVKLKIAALPADATFKQVLGIGMLAGIGFTMSIFVSELAFSGQAQHLAEAKITILAASLTAATLGYCWLRFITGAAKAETGTSVSQ
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZPR3_ARATH
Sequence: MERLNSKLFVENCYIMKENERLRKKAELLNQENQQLLFQLKQKLSKTKNSNNGSNNDNKSSSASGQS
What is the function of this protein?
Competitive inhibitor of the HD-ZIPIII transcription factors in shoot apical meristem (SAM) development.  Acts by forming non-functional heterodimers.  Part of a negative feedback loop.  Involved in SAM development and lateral organ patterning.  Essential for proper functioning of stem cells in the SAM.
What are the official names of this protein?
Protein LITTLE ZIPPER 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECB_RHIWR
Sequence: MSEETGAADTLTNGEDHLPQVALIAQYVKDLSFENPSAPGIYQAPEQPKIDVQFNIGSQQAGEDVYEVALKIEIKATQGDLTAYAVELVYAGLFGIRNVPEEHLPPFLLAEAPRLLFPFARRVAADAIRDGNFPSLVLEPIDFGALYMQQAEQQTALAESQPAGEA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_CHLL3
Sequence: MPTHTRSAELFEKAKKFIPGGVNSPVRAFKSVGGNPIFMAKGQGAYMTDVDGNTYLDYVGSWGPFILGSMHPRITAALEHTLTKIGTSFGTPIEMEIEIAELLTKIVPSIEMVRMVNSGTEATMSAVRLARGCTGRDKIIKFEGCYHGHGDSFLIKAGSGALTLGAPDSPGVTKGTAEDTLNAKYNDIKSVELLVAENKGNIAAIIIEPVAGNTGVIPAKKEFLQALRDLCDREGIVLIFDEVMCGFRVALGGAQELYGITPDLTTMGKIIGGGLPVGAFGGKRSLMENVAPLGGVYQAGTLSGNPLALTAGIETLKILMEENPYPELDRKGAFLEAGFRDNMQKLGLNFVQNRVGSMACLFFTETPVESYDSAITADTEKFGKYFSSMLEQGIYLAPSQFEAMFTSTMHTDADLEKTVKANYVALQAATK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_ANAPZ
Sequence: MLAIVDVGNTNIKFTLYVDGEFSESWYISTYHERTASELYAILRVLASQANINIHHLVGAAVSSVFPAVNGSITEMFKSFFNIVPVFITSAHASLLGINICLAQNTIGSDRLADIVAARTLYPDRDLLVIDMGTITVFNLVNKNGDLYGQVLSPGLACLVKSVRLCTAALPQVCVNKPTTKVISDATASSLESGLYWGYLSMVEGVIQRILKEESGKSLQTVATGGASNFFRDTTHVLSIDKLLTTKGILQIYRKLIENEEGR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPMT_SHEHH
Sequence: MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGHDVLGCELNELAVQQFYRENALAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAFYDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQAELNGPPFAVSDDWVQANLSQDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2525_BACAN
Sequence: MAEITIPLRDVIEVTEDATYAGVEVTSAIRIGTAYGTTDRILIKTVKQNYVLFTTNKVSILNAINA
What are the official names of this protein?
UPF0457 protein BA_2525/GBAA_2525/BAS2348.
What is the protein family that this protein belongs to?
Belongs to the UPF0457 family.
Protein: CBIA_LEPIN
Sequence: MNIKIPRIVIGGTGSGVGKTTIALALTQILRKKGLKVATFKCGPDYLDPTYHSRASQKICHNLDGWLMGKESVLNTFYQACHNVDIVIIEGMMGLFDGHSPNSEIGSTAEIAKWLASPVLVVLDTRGMARTVSAILKGLKIFDPDLNLAGAFANFTGSPSHIQLLKDASTEVPILGGLCKHSEQTFPERHLGLYSASEENVSEEKFNFWGEEGEKSLEVNSILEIANSAPEISIPVSNINTTLKRCKIGIAMDSAFHFYYEENLMRLRQAGAELVFFSPLSDSKLTDVDGLYFGGGYPEVFAPTLSKNKSLLNYIQDLSYKNIPIYAECGGLMYLSKGIKLVEGEFFPMLGLISATSIMEKKLKALGYVEVTTKKETIFGEVGLRFRGHQFRYSDLELDESNPIELVYNLRKRKSDQVSEEGYSKNSILASYIHAHWASNPNLAEGFVQSCLRK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Cobyrinate a,c-diamide synthase, Cobyrinic acid a,c-diamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: RISB_HISS2
Sequence: MKVLEGIVTAPNAKIAVVIARFNSFINESLLEGALDALKRIGQVKDENITLVRVPGAYELPLIARRLADSKKYDAIVALGTVIRGGTAHFEYVAGEASSGLGQVAMQAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALVALEMVNLLAQIDKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: METN_PASMU
Sequence: MIKLEKISKIFDVSGKKLTALDNVSLHVPKGQICGVIGASGAGKSTLIRCVNLLETPSSGAVIVDGKDLTQLKNADLVHERRHIGMIFQHFNLLTSRTVFGNIALPLELENTPKEKIHQKVNELLALVGLTDKKDAYPSNLSGGQKQRVAIARALASEPKVLLCDEATSALDPATTQSILTLLKEINRTLGITILLITHEMEVVKRICDHVAVIDKGRLIEQGSVSEIFSNPQTQLAKEFIRSTFHISLPEEYMEKLTETPRNATSWPIVKFEFTGRTVDAPVLSQASKMFGVDLSILTSQIDYAGGVKFGFVIAEMEGDDEAITRTKTYLMEHNVKVEVLGYV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GDF3_MOUSE
Sequence: MQPYQRLLALGFLLLTLPWGQTSEFQDSDLLQFLGLEKAPSPHRFQPVPRVLRKIIRAREAAAASGASQDLCYVKELGVRGNLLQLLPDQGFFLNTQKPFQDGSCLQKVLYFNLSAIKEKAKLTMAQLTLDLGPRSYYNLRPELVVALSVVQDRGVWGRSHPKVGRLLFLRSVPGPQGQLQFNLQGALKDWSSNRLKNLDLHLEILVKEDRYSRVTVQPENPCDRLLRSLHASLLVVTLNPKHCHPSSRKRRAAISVPKGFCRNFCHRHQLFINFQDLGWHKWVIAPKGFMANYCHGECPFSMTTYLNSSNYAFMQALMHMADPKVPKAVCVPTKLSPISMLYQDSDKNVILRHYEDMVVDECGCG
What is the function of this protein?
Growth factor involved in early embryonic development and adipose-tissue homeostasis.  During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (PubMed:16368929, PubMed:17936261).  Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto.
What are the official names of this protein?
Growth/differentiation factor 3, GDF-3, VG-1-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Mainly accumulated in the cytoplasm.
Protein: RL31_FINM2
Sequence: MKKDLHPEYHEATVTCASCGNTFKVGSTKENINVEVCSQCHPFYTGRQRFVEHGGRVEKFKKKYNMD
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TIAS_STAMF
Sequence: MKETIVHMGFDDIDTPFGGCTTHFVASILVKWVKDRRIKLIDYPNLIRLNPGVPWKTRGNGAVVLRFKVKNYDEAIKLLEEAYDEALEYLGKYHHPQHHPVIGMYIGGLSERIKWIGWKAVHDLIPLDLMHRVLEKEKNKIIYKLLRKDKKRGLIGVFSAIGYRMTNTDYTYELIAYRSEEYIDKPRQVNAESVKYMDKVFHNDTILNYDYETNRPLITPHGGDPVLLGIRGEYPDVLIKAYNMVKINEPVPIRLIYRTNQHTDAHLRRINNLGEAFIYRGVRVRVWVASIPKRIMGGHVIFKVTDGRRFIDVAAYEPTGKLRRIAEKLRPGDEVEVMGIVRPQSSKHGPTINLEKLHIIMVKPLIKLENPRCPRCGARMKSAGRGKGYKCPKCGYRDPNAKKIVRVIKRDLEPGWYEPSPRAFKHLMKPLKRFGKEKNHYPEEIEPSNFIWYNNMLLK
What is the function of this protein?
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
What are the official names of this protein?
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS, tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the TiaS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL1B_FELCA
Sequence: MAPVPELTSEMMAYYSDENDLFFEADGPEKMKGSLQNLSHSFLGDEGIQLQISHQPDNKSLRHAVSVIVAMEKLKKISFACSQPLQDEDLKSLFCCIFEEEPIICDTWDDGFVCDAAIQSQDYTFRDISQKSLVLSGSYELRALHLNGQNMNQQVVFRMSFVHGEENSKKIPVVLCIKKNNLYLSCVMKDGKPTLQLEMLDPKVYPKKKMEKRFVFNKTEIKGNVEFESSQFPNWYISTSQAEEMPVFLGNTKGGQDITDFIMESAS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.