PharMolix/UniProtQA huggingface dataset:
Protein: RPOA_BORGP
Sequence: MPVEKFLKDFTIPEKIEFLKSQDDGSYGKFTIYPFERGFGVTIGNTLRRVLLSSIEGYAITAMRIQSNNKDSSSKVVSSEFDLIPGVSEDTLEVIANIKNIHLKLGEGEQRKIISFSVSGKDTKVLKASHFERDGVEVFNRDLVIATLSQDVNLDLEFQINYGRGYVSSEQNSKYLEEVNVIALDSIFSPIEKVSYSVEDTRVGQRSDYDKLVMEIWTTGVISAKDAIKKAASIIREFLFPLIDFEDNINTSFEKSKSESSNLLDMSIEKLDLSVRSLNCLAKENVRTLGELISKNAEELSKARNFGKKSLEEIIEKLSSYQLFLGMSKEDALFVLSKNVKISE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MURA_SALA4
Sequence: MDKFRVQGPTTLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDASQVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHITGLEQLGATIKLEEGYVKASVEGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLVTLGAKIAGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKILCRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGARAEIESNTVICHGVETLSGAQVMATDLRASASLVLAGCIAEGTTIVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_CHAVU
Sequence: MSPQTETKTSAGFKAGVKDYRLTYYTPEYKTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEAIYKSQAETGEIKGHYLNATAGTCEEMLKRAQCARELGMPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVLDRQKNHGMHFRVLAKALRLSGGDHVHSGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGVYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREAAKWSPELAAACEVWKEIKFEFETIDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFGM_NEOFI
Sequence: MRCPSLARLPHRALSGLTKSPVRLQSQNFLYQRCASTAALRSPIAGPAYQSVFNRHNLQRRNASAATAAAVLEAAASNPDGLSQEAIIDNLDPAEAIRLSRLRNIGIAAHIDSGKTTCTERVLFYTGRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATFCDWVKKGDDGKEEKYHINLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMRRYNVPRISFVNKMDRMGANPFKAVEQINTKLKIPAAAVQVPIGAEDEFEGVVDLIRMKSLYNEGPSGENIVIKDEIPEKVKSVVEERRRMLIETLADVDDEIAELFLEETEPTEQQLKAAIRRATIGLKFTPVFMGSALANKSVQPMLDGVIDYLPNPSEVENLALDRKRDEASVKLVPYNSQPFVGLAFKLEESNFGQLTYIRVYQGTLRKGANVFNARNNKKVKVPRIVRMHSNEMEEVSEIGAGEICAVFGVDCASGDTFTDGQLGYTMTSMFVPEPVISLSIKPKNNKDSANFSKAMARFQREDPTFRVSYNAESEETLISGMGELHLDIYIERMRREYRVDCVTGPPQVAYRETIGNRVEFDHLLKKQSGGPGEYARVVGWMEPTGKLEDNKFEEQIVGGSISEKFLFACEKGFNLACEKGPLIGHKVLGTRMVINDGATHMTDSSEMSFKNATQQAFRKAFMESNPSVLEPMMKIVVTAPGEFQGDVISLLNKRNATINDTETGVDEFTVYADCSLNGMFGFSTHLRAATQGKGEFTMEFSHYEKAQPQLQKELIQKYLKAQADRHKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TORD_SALNS
Sequence: MIKQPALAQEQYACVYAWLALLFFREVDDEGLIQLQSAEIADWLALLKRQPALAASVALLEQKIAALSLRQDAQLELAADFCGLFLMTDKKSALPYASQYPQQEPGMIKHLLLEAGMEVNDDFKEPTDHLAIYLELLSHLHFSLGESFQQRRMNKLRQKTLSSLLEWLPEFTNNCLKHDPYGFYAALSQLLLAIVRFDDGKEDLSIVAAE
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_STRT1
Sequence: MMTQMKTSSDEMKVAIIANGKPQSRRVASKLFNAFRDDPDFYLTKKNPDVLISIGGDGMLLSAFHMYEKELARVRFVGIHTGHLGFYTDYLDSEVDQLIETLRKDSGAKISYPLLNVKLTLADGRSFTSIALNEAAIKRNEKTMAADVCLNDVLFESFRGDGLSVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSPLIVPKHEKITVYPTRMGSYTLSVDNKTYINRNVKKVEFSIDQRKISFVASASHTSFWERVRESFIGDMEE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_RHOJR
Sequence: MTERTLVLIKPDAVARGYVGEILGRIERKGLTISALDLRTAPGDIAAAHYAEHEGRPFYPGLLEFITGGPLVAAVLEGPRAIAAFRQLAGGTDPVEKAVPGTIRGDFGLEAQENLVHGSDSVESAEREIALWFPHLAAN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAE2_BDEBA
Sequence: MTNKALIPSQNSRLPAKPRPRAKGFVELLGRSNFSFLQGASSPEEMVSQAVEFGYDGMALCDLNGLYGVVRGFQTIQSPSLFTASPQVKENFHYLIGSELTLTDESSVVLIPMNKQGYSHLCEILTLGKRQAAKGFSKLSLEQIEKYNQGLLCLALPPWTDERYEKLEKIFDNRLYLPLWRDLTWESQEFCRQGFALEEKYKAQLFVTQRPFMHSPERKPLFDVLTCTLHHTTLAEAKNKLIQNSERCLKSLEDISWLWQDRLDLVEKTVEISARVTFSLNEIRYRYPASSLPSGMTPTEYMRHLTLKGAESRYPEGIPDKALKQIEHELELIKDLQYEDYFLTLKEICDFASERKILYQGRGSAANSVVCFCLGLTAIDPVKMDLLFERFLSRERREPPDIDIDFEHSRREEVIQHIYEKYNERHAAMVCTVIRYRSRMAIRETAKVFGMPLAKINAMIKFMGRDGMKRLLDPAVAADFGMEPGPWKMFMALAQQLHGFPRHLGIHTGGFLITQDPITEMVPVEKATMNGRYVIQWNKDDVDFLRLMKIDVLSLGMLTCLRKCFDLLRDVKGRDYSLATLPADDKPTYDMICRAETVGVFQIESRAQMNTLPRMQPRNFYDLVIEIALIRPGPLQGGMVHPFLKLRQNPPKEIKYAHPALEPILKKTMGIPIFQEQVMKMVVAVADFTPGEADELRRVMSSAWKRKATMGGIEQRLRTGFARHGISSEYADQIFKTIEGFANYGFPESHSASFALLTYASCYLKCHYPDVFACGLLNSQPMGFYAPRTIIAEAQRNGVVVAPLDVQKSDYDYTIEKTAAGDLLRVGLRSIYGIPEVLIRRIEDSRKEEGLYIDLADFIRRTQLPRSVLLKLAAAGAFESFNSNVRELIWNLESLSLDQQSFLWGHPKEQFELGEDDDEPEHLPFESNWDRLRREYDSKGYSVESHPMSVLRTYLHSKSEALREKRFVPYFSSEDLKRMKTKTKVRVAGLVAITQRPPTAKGMCFITLEDEFGFVNIVIHPEIYQKDRTTIYTRSLLEIHGQVEKVGAITNIRAERILPLG
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGD_STAAS
Sequence: MKQYKAYLIDLDGTMYMGTDEIDGAKQFIDYLNVKGIPHLYVTNNSTKTPEQVTEKLREMHIDAKPEEVVTSALATADYISEQSPGASVYMLGGSGLNTALTEAGLVIKNDEHVDYVVIGLDEQVTYEKLAIATLGVRNGATFISTNPDVSIPKERGLLPGNGAITSVVSVSTGVSPQFIGKPEPIIMVKALEILGLDKSEVAMVGDLYDTDIMSGINVGMDTIHVQTGVSTLEDVQNKNVPPTYSFKDLNEAIAELEK
What is the function of this protein?
Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
What are the official names of this protein?
Acid sugar phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. NagD family.
Protein: PKP3_ARATH
Sequence: MAAYGQISSGMTVDPQVLSSSRNIGVSLSPLRRTLIGAGVRSTSISLRQCSLSVRSIKISEDSRKPKAYAENGAFDVGVLDSSSYRLADSRTSSNDSRRKTKIVCTIGPSSSSREMIWKLAEAGMNVARLNMSHGDHASHQITIDLVKEYNSLFVDKAIAIMLDTKGPEVRSGDVPQPIFLEEGQEFNFTIKRGVSLKDTVSVNYDDFVNDVEVGDILLVDGGMMSLAVKSKTSDLVKCVVIDGGELQSRRHLNVRGKSATLPSITDKDWEDIKFGVDNQVDFYAVSFVKDAKVVHELKNYLKTCSADISVIVKIESADSIKNLPSIISACDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSIHKPVIVATNMLESMINHPTPTRAEVSDIAIAVREGADAIMLSGETAHGKFPLKAVNVMHTVALRTEASLPVRTSASRTTAYKGHMGQMFAFHASIMANTLSSPLIVFTRTGSMAVLLSHYRPSATIFAFTNQRRIMQRLALYQGVMPIYMEFSDDAEDTYARSLKLLQDENMLKEGQHVTLVQSGSQPIWREESTHLIQVRKIKIGG
What is the function of this protein?
Required for plastidial pyruvate kinase activity.
What are the official names of this protein?
Plastidial pyruvate kinase 3, chloroplastic, PKp3, Pyruvate kinase I, Pyruvate kinase isozyme B2, chloroplastic, PKP-BETA2, Plastidic pyruvate kinase beta subunit 2.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: NR4A2_BOVIN
Sequence: MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFTDLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
What is the function of this protein?
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.  It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 4 group A member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.
Protein: CODY_GEOTN
Sequence: MNLLEKTRKINAMLQKAAGRPVNFKEMAETLCDVIEANVFVVSRRGKLLGFAIKQSIENERMKRMLEERQFPEEYTRNLFNITETSPNIDINSEYTAFPVENRDLFKTGLTTIVPINGGGERLGTLILSRLDREFDNDDLILAEYGATVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGTEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNDKFLTELEKLKSN
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHYM_FELCA
Sequence: SEITRVPLHKGKSLRKALKEHGLLEBFDKVSNEPLADFLDSEYFGKIYIGTPPZ
What is the function of this protein?
Chymosin is synthesized in the mucosa of the stomach.  The enzyme hydrolyzes casein to paracasein.
What are the official names of this protein?
Chymosin.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
Protein: HISZ_PROMP
Sequence: MSDIKEFNLIDVRNNSSIVNDLNNVYKLWGYEEISPSFINNLETIKGREVIDGDELIGIVSNSSLCLRPEMTTSIVKLTSTRLLNKKRPIRLFNSGIVFNKKQSYKNTYKFQENLQSGIELISYDTQYPEIEVINILFDAIDNINLIDSCNLTLLVSTTKIMDLILFNYKNNNYEEIKKCMVNLDHESLDKLNIDNNDKAILKELLFTRGEPAIILKKLKNIYGNNNVIEELDCLFNTLSKISKKYNIKIQLDPTYQPHLNLYAGIVFQLICDNKNVKTIIAKGGRYDELVRYFNPNEKIINGIGFTISIDNLRELIVEKSQTKKKVLLLFKNSYLLDKGINEQKALQKKGIITILYLNPCNDNSKANILMKEHNCTEIQWIK
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_HERA2
Sequence: MFMQKFRAAATSNRSTLCIGLDPDLARLPEHLPRDAAGIVQFNQAIIEATSDLVCAYKPNMAFYEALGSAGWLALKQTIASIPSHIPVLLDAKRGDIGSTAQAYASAAFDELGVDAITLSPYMGYDSLQPFLERADKTCFILCRTSNPGGDDVQNLLLDNGEPLFLKIAELVAKRWNSNHNCGLVVGATYPAEIATIHQRYPELPLLVPGVGSQGGDIEEVLAAAGEQAIINVSRSVLYASGGSSFAEAARKVAQAFLVPKQALNHP
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: HSLU_SINMW
Sequence: MSSFSPREIVSELDRYIIGQKDAKRAVAIALRNRWRRQQLSDELRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIVRDLVEVGISLVREKRRAEVKAKAHQNAEERVLDALVGTTASPATRDSFRKKLRANELDDKEIEVDVAETGNPGGAFEIPGMPGANIGVLNLSEMFGKALGGRTRKIKTTVKDSYALLVNDESDKLLDNEQIQREAVASAENDGIVFLDEIDKIATREGGIGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFIASGAFHVAKPSDLLPELQGRLPIRVELRALTKEDFRRILTETEASLIRQYKALLETEGVTLDFTEDAIDALAEVAVQLNSNVENIGARRLQTVMERVLDDVSFNAPDRGGQGVTIDADYVRVHVGDLAANTDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_MARN8
Sequence: MKEGIHPKYEDITATCSCGNVIKTRSTIGHDLQLDVCSQCHPFYTGKQKVMDTGGRIDRFQKRFGSRIGGKKG
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MUTS_LEUMM
Sequence: MAKVAETPMMVQYHEIKSQYPDAFVFYRLGDFYELFEDDAVLGAKLLELTLTARNKNSENPVPMAGIPHHAAQNYIDILVDQGHKVAIVEQMEDPATAKGMVKRDVVQLITPGTKLNSGMGNDKQNNYLAAVLPRDNRYFLSYIDLSTGELKTTTLKRFSDVIDELSSLEVKEIVLLKDDETTELGIANKLAERGLVISTQSDVNVNATVSFLTQPLVHENEAQVTTILLNYIFDTQRRNLDHIIPAQNYERLAYLKFNQDTRTNLDLVKNARTKKKAGSLLGLIDETKTAMGGRLLKQWLLRPLRDTEDINERLDVIEAFQNEFFVRGALQDHLKSVYDLERLAARAAMGTMNARELVQLKRSLSAIPGMKSVLSSSQGILNHASQRLEDMSDLAGLIDEAIVDDPPISIREGDIINDGFDSKIDEYRNVLSQNQKWLAQLESDERAATGINSLKVKYNKNFGFFIEVSRANVSKLEEGRYERKQTLTNAERFVTPELKEHERLINEAQLKRTEREYELFITIRERVKANISRLQKLARQVAQLDVLASLADVADNNRFVRPTFTDDNIINIKQGRHPVVEAILEAGEFVANDVNLDQNTAMQLITGPNMAGKSTYMRELALIVILGQMGSFVPAESAVLPIFDQIFTRIGANDDMAMGQSTFMVEMAEANLALQEASAHSLILFDELGRGTATYDGMALAQAIIEYLDAHVHAKTLFSTHYHELTALADKHENIKNVHVGAVEDESGELHFLHQIQQGPADKSYGIHVAALAGLPDELIANATTILSGLENQEALVPEPKASGLSEQVALFNVSDVDPKTETLFQKLDSINISTMTPLEALNVLAELQKLRK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: KDSB_PHOLL
Sequence: MFTVIIPARFASTRLPGKPLADIHGKPMIVRVMERAKRSGAGRVIVATDNHDVVDAVVAAGGEACLTNENHHSGTERLAEVINKYQFSDDEIIVNVQGDEPLIPEEIIKQVAENLAGCKAGMATLAVQIHDAEEAFNPNAVKVVMDKQGYALYFSRATIPWERGRFIQSRETIGDNFLRHIGIYAYRAGFIRRYVQWEPSPLEQIEMLEQLRVLWYGEKIHVGIALKAPGVGVDTPEDLAAIRKVFTEI
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN5_CAEEL
Sequence: MEVDNVKPSSSVPQRNWEKENNVQNVDSIFEYNNKQQVEIRNAKPWDKDPHYFKQIKISAIALLKMTMHAKRGGNLEIMGLLQGRIDANSFIILDVFALPVEGTETRVNAQAQAYEYMTVYSEMCDTEGRKEKVVGWYHSHPGYGCWLSGIDVSTQTLNQKFQEPWVAIVIDPLRTMSAGKVDIGAFRTYPEGYRPPDDVPSEYQSIPLAKIEDFGVHCKRYYSLDVSFFKSQLDAHILTSLWNSYWISTLSSSPLFSNVEFLNNQIQDINQKLSAVDKKLQLNDRSVDGHEALMKVVTDAKAVGDELETGRISHLVKQLLFARQAGGGCGCSHASAGSPMDIAVATEPEKAGPSPSAPEPAVEMADA
What is the function of this protein?
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins.  It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity).  The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo.  Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.  May stabilize glh-1 protein levels by antagonizing kgb-1 (PubMed:17699606).
What are the official names of this protein?
COP9 signalosome complex subunit 5, Signalosome subunit 5, JAB1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNH2_LACLA
Sequence: MGQTIKEIKATLAKLTDLSAKEFLEYEADERAGVQAALKSRKKQILAELAEEARLEQMLEFEKELYGQEIQLIAGIDEVGRGPLAGPVVTAAVILPKNCKIRGLNDSKKVPKSKHHAILSEIQEKALAIGIGIVDAEKIDEVNIYEATKIAMIQAVSKLSVKPEHLLIDAMVLDFPIAQTKIIHGDARSASIAAASIVAKVTRDEMMKEFALEFPEYDFEHNAGYGTAKHLEALTKYGITRIHRKSYEPIKTMVNFKS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_FRATW
Sequence: MSKENKTTDFGFTQVPWEEKQKKVAGVFHSVAAKYDLMNDLMSFGIHRIWKKQTIAKSGVHKGDNVLDLAGGTGDLAYKFCQMVGQQGKVILSDINSSMLEVGKEKLTNKGCVGNIEYVQANAECLPFPDNYFDCITISFGLRNVTDKDKALASMCRVLKPGGRLLVLEFSKPIIPLLSKVYDEYSFKALPFLGKIITQDAESYKYLAESIRKHPDQQTLKQMMYDAGFDNVEYQNMTGGIVALHIGYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: OPRM_PSEAE
Sequence: MKRSFLSLAVAAVVLSGCSLIPDYQRPEAPVAAAYPQGQAYGQNTGAAAVPAADIGWREFFRDPQLQQLIGVALENNRDLRVAALNVEAFRAQYRIQRADLFPRIGVDGSGTRQRLPGDLSTTGSPAISSQYGVTLGTTAWELDLFGRLRSLRDQALEQYLATEQAQRSAQTTLVASVATAYLTLKADQAQLQLTKDTLGTYQKSFDLTQRSYDVGVASALDLRQAQTAVEGARATLAQYTRLVAQDQNALVLLLGSGIPANLPQGLGLDQTLLTEVPAGLPSDLLQRRPDILEAEHQLMAANASIGAARAAFFPSISLTANAGTMSRQLSGLFDAGSGSWLFQPSINLPIFTAGSLRASLDYAKIQKDINVAQYEKAIQTAFQEVADGLAARGTFTEQLQAQRDLVKASDEYYQLADKRYRTGVDNYLTLLDAQRSLFTAQQQLITDRLNQLTSEVNLYKALGGGWNQQTVTQQQTAKKEDPQA
What is the function of this protein?
The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux.  It is thought that the MexB subunit is a proton antiporter.
What are the official names of this protein?
Outer membrane protein OprM.
What is the protein family that this protein belongs to?
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18-Gly mutant is reported to be periplasmically located, in another (PubMed:11114896) the same protein is reported to be located in the outer membrane.