PharMolix/UniProtQA huggingface dataset:
Protein: CP3A7_HUMAN
Sequence: MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:9555064, PubMed:17178770).  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:14559847, PubMed:12865317).  Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772).  Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064).
What are the official names of this protein?
Cytochrome P450 3A7, CYPIIIA7, Cytochrome P450-HFLA, P450HLp2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: ACEK_PARPJ
Sequence: MNHFPKLLSSQIGFDLAQTMLEGFDRHYRIFRDAAIHAKTLFEKGDWHGLQKLARDRITSYDERVDECVELLEDEYDAEKIDSEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHRSYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGLAATLERIVTNFQLEPQFEDLTRDVGCVMQAIHDAFGAFDEAPNFQIHVLSSLFYRNKSAYIVGRIINGDLLLPFAVPLRHVKPGVLALDTVLLKREQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDNFPPPKETTRAQIQSKYQLVKRHDRLGRMADTLEYSSVALPRSRLDDALVRELEKEVPSLLEYEGENLVIRHMYIERRMVPLNLFLQNGNDEDVEHGIKEYGNAVKELMQANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRVRRSFMQHHADFFDPALWQRHKDHLLKGELPDFFPYDDSARFCNCYPERFADAAGRASPEPDAPADARSVRVA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEA_FUSO4
Sequence: MATPSSIPAEPKRDVINRIHRVTRENRSLWYQMTVLQQPERARACGSGSKANSDRRPVDPPPVVELRIIEGPSVEEGKDITFDYNANFFLYASLEHARPLARGRVNTPAAGNPPILTGVPASGMAYLDRPTEAGYFIFPDLSVRHEGLYILTFSLFETTKEERDYDLEPADGDLPPGVDYRMEIKTEPFSVYSAKKFPGLMESTQLSKTVADQGCRVRIRRDVRMRKRESKPGAGNSNSGGNGFERREEDFSRRRTITPASEDPHSIRNRSHSNSSEHRTPYTDASRRPSMVDSYPPPPPPPPPSYEPAPSASRHLDFGDSSAAQYPTPRQYAHQPGLQITPGPPNGSYAPTAQSPYSKTDVPYGYVNRNIPPSCPSPAPSLKHELYDRRQSTSTYVPPSPSVYSTEGHHRRDSRPSYPPTPVAAPHPRPMHSQTSLPALKIDQLVSPVSPLPPIEPQTGPAPELPPINVGGKRKHESVFAQSTRPLHNGQRQVDPHYGRSHRGYSPDHDQGWYSRADGQISSVQFNRYYDE
What is the function of this protein?
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity).  The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity).  Controls the biosynthetic gene cluster for beauvericin, a depsipeptide mycotoxin that functions as a virulence determinant (PubMed:23106229).  Regulates also chromatin structure and transcription of siderophore biosynthetic genes and is required for infection of tomato plants (PubMed:23106229).  Governs expression of nitrate metabolism genes (PubMed:24240057).
What are the official names of this protein?
Developmental and secondary metabolism regulator veA, Velvet complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VeA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enriched in the nucleus in the dark (By similarity).
Protein: NO66_BRAFL
Sequence: MAQNIPTKRQSAFGVFVKSKVKGPTIQQTGATKTPKTPSKIRRLSIRKSTRKIKHALKGKSGSQPVAAHKDMPVTQNTGQGEEGVKLKGYKMKTSPARVQEPQRTGSPEENSIGKGNIKTNIKGSQNVQAGQKFQERIATQHPQKRKPFGIEDSDDKTPVKRVRSDTAKSVQSPAKAVDVGEVEDSTEEAEKMFEWLIHPVKKEKFFSELWEKKPLLVKRHLESYNDGWFSTEDLTKILHENDIQFGRNLDVTTYEGGQRETHNPPGRANPAVVWDYYQNGCSVRLLNPQTYSQGVWRLCSTLQEYFSSMVGANIYLTPPGTQGFAPHYDDIEAFVLQLEGNFSQEEIGEAILDVTLEPGDLLYFPRGTIHQASALPDTHSLHITVSTCQRNTWGDLMEKLVPAALTMAFSEDVEFRQALPRDYLDYMGLANADLDDPRRKAFLETLQSLLSRLVNYVPVDAGVDQKAVEFMRDCLPPVFTKNERACSIYGCRTRLEKGRVVGSVDLKTSTPVKLIRKGAARLVMEGEQVFLYHVLENARVYHGAELQPIEVPPEAAPAIEYLMHSYPEYVTVDSFPLDHQQDKIDLAMLMFEKGIIIAQEPASVDN
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.  Also catalyzes the hydroxylation of 60S ribosomal protein L8 (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y479_GEOKA
Sequence: MSIKYSSKINKIRTFALSLIFIGVIVMYLGLFFRTSPVIMTLFMLFGMLFLVASGIVYFWIGTLSTRAVQVVCPSCGKVTKMLGRVDLCMFCREPLTLDRELEGKEFDEKYNKKRKS
What are the official names of this protein?
UPF0295 protein GK0479.
What is the protein family that this protein belongs to?
Belongs to the UPF0295 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMT_GLOVI
Sequence: MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPVFQPDRLRKDLEVLAHLEALQADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAAPVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDEDITGEQLLAQLAHLGAGLLLETLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRLRLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGCRLMPGESLGL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: AIM6_ZYGRC
Sequence: MNGVKSWTVTLVFYFLILAVLIANLDGSSSLFGIIPKRANSSQKPPHLHLQQLGITGSRLLRFFQDNLLEFEGASSLPGDEQPGISLYYDSFKKYLYDAPHGPPRPLECNPDKSIVAKLTKDVQPIPVHSHNDYWRDLPLFQGIAHGAISTEADVWIYPKPTNADTPEDEYILAVGHNEVFLDPVHRTLDGLYTGPLADMLDQVNCVEGHKSGVFYDSPEDTLFFYIDFKSQETHLLYKLLMDKYLKPLMDKGYLTYFDLESKKLVWNQITVILTGDFPKDLGVIDNGENGYYNDNKRYAFQEANILEPTALEPNASVVSTSSLSNLLEKCGYNERSILSQGQMDNSLTKCIKSLISQSHEAGLRTRIWGVPNWPVSFATNLWHQQVENLGVDLLNVDNLDLAQSIF
What are the official names of this protein?
Altered inheritance of mitochondria protein 6.
What is the protein family that this protein belongs to?
Belongs to the AIM6 family.
Protein: SSRP_BACC0
Sequence: MPKGSGKVIAQNKKAFHDYFIEETYEAGLVLQGTEIKSIRAGRVNLKDAFARVHNGEVWVHNMHISTYEQGNRFNHDPLRTRKLLLHKKEIEKLAGASKETGYALVPVRIYLKNGFAKMALGLAKGKKQYDKRHDLKEKEAKREIARAFRDRQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PHNW_BACAN
Sequence: MTENHYLLLTPGPLTTTKTVKEVMLYDWCTWDVEYNTMVQKVRAKLVSLATKEEEKYTTVLMQGSGTFSVEAVIGSVIPKNGKLLVCTNGAYGKRIVQMAEMLHIDVVVSQTEEWEPTNIVEVEKILQQDKEITHIAVVHCETTTGIINPIVDVCKLGKQYGKVTLVDAMSSFGGIEIDIAELQIDFLISSANKCIQGVPGFGFVIAQRDELLKCKGQARSLSLDLYDQWETMENQNGKWRFTSPTHVVHAFYQALLELEKEGGVRARYNRYYNNQKLLVNRMGEIGFKPLVNEKYQSPIITSFIYPEGNFEFQQLYNELKRYGFVIYPGKISKVDTFRIGNIGDVHEEDINRLVDSIAKGVVIG
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: YP191_YEAST
Sequence: MDLSFTTKSVKINGQNHRILLQNENGPCALLALANILILSPDHTRFSNELIRLVNKGSQISLKELIEVLADIALQVTDKPSTDISELLSLLPRLHEGLNINPEFNGSFENTKEMSIFRLFNVDVVHGWVINSFINENIDEKLSHYSYESAQRILTQAADINCGISQDENSDEVLRDAMHLGLFLNESPTQLTAFGLLRLREKLLHNKFSILFRNDHFSTLFKYEDRLYTLVTDFGYKNCKDIVWQSLDSVDGSCDAFFAGNFSAAEVNGQQLSTDIERDFGTGNLLLEEIQQIENDKELAKQLQEQEQERVTKFEAKRKIHSHKKNSEIHAPVKKDKFKRRSSLLNAKASEKEKSECVVM
What is the function of this protein?
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins.  Has endodeubiquitinase activity.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MIY1, Deubiquitinating enzyme MIY1.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPFCB_CUTAK
Sequence: MTANPYAAPTDPLAPYSAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRFGGVSPINDATDVFVNAIGNELRRHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVVTSAYASYSGCRQYREEIATALAHAGITDMQVDKVPPFNEAPGFIRANAEALMQAFMRIPPTPLEATRVVFVTHSIPDSMQDASGAGQPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLAYCSRSGRPSDPWLEPDIIDHLRSLPEQGVQSVVVAPIGFVADHMEVVNDLDYEAAEAAKESGLAFTRAATAGTHSAFIADLAGLILSQAAAARGEGGNLTSWPAPCVAGCCRRYPDAQDIPAVSGGDVESVAAGADVVDAEPGGVDFVPSGSASAVDRPGPEAVELETPPSPYNPLTKETPMSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALPAEDDERRRLVEGSDEWAGQSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRASGLGRHLEPVWSNVGVHRPAEFNKSHLPSCFAGIAPRRWAAFYPFIRSKEWYLLPAADRSRMLREHGIVGAASSDVKASTLAAFALGDYEWILALEGDDLARIVDVMKDLRYVEARRYVDVDTPFFTGERVSPVVWADRQMRA
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:25646457).  Catalyzes the insertion of ferrous iron into coproporphyrin III to form coproheme III (By similarity).  Also catalyzes the decarboxylation of coproheme III to heme b (protoheme IX), the last step of the pathway (By similarity).
What are the official names of this protein?
Coproporphyrin-dependent heme b biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ChdC family.
Protein: NDHI_TOBAC
Sequence: MLPMITEFINYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTISNLPQIKNE
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SYN_BACHK
Sequence: MENTLVKSLYRDTDKYAGQTVQVSGWIRNLRDSKAFGFIELNDGSFFKSVQIVFDTELDNFKEIAKLPLSSSVKVEGKVIATPGAKQPFEIKAEKIDIEGLSDSDYPLQKKRHTFEYLRTIAHLRPRTNAFSATFRVRSIAAFAIHQFFQERGFVHVHTPIITGSDTEGAGEMFRVTTQDLNNVPKDEDGQVDESKDFFGKETNLTVSGQLNAEAYALAFRDVYTFGPTFRAENSNTTRHAAEFWMVEPEIAFAELGDVMNLTEDMLKYAMKYVLEHAPEEMEFFNSFVDKTVLERMNNVINSDFGRITYTEAIKVLQESGADFKYPVEWGIDLQTEHERYLSEEIFKRPVFVTDYPKDIKAFYMRLNDDGKTVAATDLLVPGIGELIGGSQREERMDVLVDRIKELGMNEEDYWWYLELRKYGGTKHAGFGLGFERFLMYITGMANIRDVIPFPRTPGSSEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_OCEIH
Sequence: MLFVLDVGNTNTVLGVFDQGELTHHWRIKTDRYKTEDEFGMLIHSLFQHKKLSFEDIKGVIISSVVPPILFALEKMSRDYFHLDAVVIGKTSYQTFLNMNYPNPQEIGADRIVNAVAATEEYGSPLIIIDFGTATTYCYIDEDTAYAGGIITPGINISMEALYSNASKLPKIEIQKPETVIGSTTVDAMTSGVFYGYIGQVDGLVKRIKDEKGTNPTVIATGGLAKLIAHESASIDIVEPYLTLKGLHLIYQKNN
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR329_MIMIV
Sequence: MSVSDIISKSLIEYDSTTPTIQYLIENTYFEGYKTNSDTERSRLKFIHKDTNKVLFETEIETLAIYYDKLNIWSWSWSQVGLYNSENYLAKEMLLYALKLGYDMSYIKSIITTSRGVIRDPIQVDINLAIGSGIIKQPYIYPYVYEVEKRKLYYYIILLNKQELDKLSKKLNKQSNE
What are the official names of this protein?
Uncharacterized protein R329.
Protein: MEND_SHISS
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHSGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLILIVVNNNGGQIFSLLPTPKSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETALADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RS5_PSET1
Sequence: MANVEAKQQQPDLAEKLIAVNRVSKVVKGGRIFSFTALTVVGDGAGKVGFGYGKAREVPAAIQKAMEKARRNMINVDLNGNTLQHPVKGRHAGSQVFMKPASEGTGIIAGGAMRAVLEVTGVQNVLSKCYGSTNPINVVRATISALENMNSPQSIAAKRGLRIDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: THIG_MYCS2
Sequence: MADSVLRIGGREFGSRLIMGTGGAPNLSVLEEALIASGTELTTVAMRRVDAETGTGVLDLLNRLGIAALPNTAGCRGAAEAVLTAQLAREALGTDMVKLEVIADERTLLPDAVELVKAAEQLVDDGFTVLPYTNDDPVLARRLEDIGCAAVMPLGSPIGTGLGISNPHNIEMIVAAAGVPVVLDAGIGTASDAALAMELGCDAVLLATAVTRASDPPTMAAAMASAVTAGHLARQAGRIPKRFWAQASSPAL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_RHOPB
Sequence: MFKVRVIPCLDVKDGRVVKGINFVDLRDAGDPVEAAIAYDAAGADELCFLDITATHENRGIMLDVVRRTAEACFMPLTVGGGVRTVDDIKVLLRSGADKVSINSAAVSRREFVKEAAEKFGDQCIVVAIDAKRVKRGGGGERWEIFTHGGRNSTGIDAIEYAQEVVSLGAGEILLTSMDRDGTRQGFDIPLTSAIADSVHVPVIASGGVGTLDHLVDGIRNGHATAVLAASIFHFGEFTIRQAKDHMVRAGLPMRLDP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_ALISL
Sequence: MTTDIKQLELKISDLECQMAFQEQTIDELNDALSQQQLLITNMQVQMKFVVGKMKTMDTSSMADASEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: TRMB_PARXL
Sequence: MIHDPNDAGLPDQLPTPSSEAENSPAGDTTPPEEALHRRRIRSFVTRAGRVSTGQRRAMDELGPRFVVPFAPQQPDWNSVFGREAPRVLEIGFGMGATTAEIASHRPDEDFLGVEVHEPGVGALLKLMGEQNLSNIRIIQHDAVEVLEQMIAPDSLDGVHIFFPDPWHKARHHKRRLIQPKFVALLVSRLKPGAYLHCATDWQNYAEQMLEVLGAEPSLKNTADGYAPRPEYRPVTKFERRGLRLGHGVWDLVFRKRGAG
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RPOA_CAUSK
Sequence: MIERNWNELIRPEKPQIETGADATRKARIVAEPLERGFGVTLGNALRRVLLSSLQGAAVTAIQIDGVVHEFSSLEGVREDVVDIVLNIKQLAVRMHAEGPKRMTLRATGPGVVTAGQIETPSDIEILNPDHVLCTLDDGASVRMEFTVNTGKGYVPADKNRPEDAPIGLIAVDALYSPVKRVAYRVEPTRQGQSLDYDKLILEVETNGAVTPVDAVAYAARILQDQLQIFITFEEPKAKTADEAKPELPFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLAGMGLHLGMDVPNWPPENIEDLAKKFEDQI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RL16_TROW8
Sequence: MMLIPKKVKFRKQHRPNRKGMSGCGTRIVFGDYGIQALSRAYVTNRQVESARIAMTRHIRRGGRVWINIYPDRPLTKKPAETRMGSGKGSPEYWVANIRPGRIMFEVSGVSESLAKEALMRAIHKLPLRARIVERQEFDDAGL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: H3_ASPCL
Sequence: MARTKQTARKSTGGKAPRKQLASKAARKAAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CI085_RAT
Sequence: MSSQKGNVTRSRPQKHQNTFTFKNDKFDKSVQTKKINAKLHDGVCQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACKLEVCAKCGKEEEIVIPFNKEPEPSENTESEGSNHRRSCKRKEDSDEDLDAESDSEGEDEDTQA
What are the official names of this protein?
Uncharacterized protein C9orf85 homolog.
Protein: EXOS8_BOVIN
Sequence: MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNVGSIGTADGSALVKLGNTTVICGIKAEFGAPPTDAPDKGYVVPNVDLSPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISSGKLAWVLYCDLICLNHDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSCLNIRTHPVATSFAVFDDTLLIVDPTEEEEHLATGTLTVVMDEEGRLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVFKSMKPK
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  EXOSC8 binds to ARE-containing RNAs (By similarity).
What are the official names of this protein?
Exosome complex component RRP43, Exosome component 8, Ribosomal RNA-processing protein 43.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus.