PharMolix/UniProtQA huggingface dataset:
Protein: PKG1_ADES1
Sequence: MSGAADGTVPVGEDTHQEDSGERECEQRPVHSGREATGESDPALERPDHGERHGPEPRFPSFSVRPEAAQPPPSRTIARESFLGRFITDCLKWKNDVVKIDPNICKDPFPSDDEIFGNIGSHSTLLRELHECAYRYQKAVNASHPLLQRDGSLKTLNYGVQPFIVTVYGPTGSGKSQFLRNVISSKMIDPPPETVFFVTPEKGTVTNEEKLSWEAQCAEGVYNSKCVPITKTFQPAFVNLSFSEAVDEENLSIDSPNNVFVQAAKKGPICIIIDECMNQLGACRSISSFFHALPSKIFGRFPACTGYTVLVVLHNMNPRSDRGNIKDLKIQSKCHIISPQLESQQVSRFIKNFSFGFPTPLVSVIKDIVDHAKMHSKFSWLVYCSVPVRESFRWSYYSPEDQLTPLYVDLQAVMYEACHNIRRVFCKRLYSRVSYANKRKWYD
What is the function of this protein?
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP).  Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery.  The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase.  May be the protein that pumps DNA into the capsid powered by ATP hydrolysis.  Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence.  Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication.  DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
What are the official names of this protein?
Packaging protein 1, Packaging protein IVa2.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae packaging protein 1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus, host nucleoplasm. Host nucleus, host nucleolus. Note=Located at a unique vertex of the capsid. Present in about 6-8 copies per virion.
Protein: PAP1_CWPXG
Sequence: MNRNPDQNTLPNITLKIIETYLGRVPSVNEYHMLKLQARNIQKITVFNKDIFVSLVKKNKKRFFSDVDTSASEIKDRILSYFSKQTQTYNIGKLFTIIELQSVLVTTYTDILGVLTIKAPNVISSKISYNVTSMEELARDMLNSMNVAVIDKAKVMGRHNVSSLVKNVNKLMEEYLRRHNKSCICYGSYSLYLINPNIRYGDIDILQTNSRTFLIDLAFLIKFITGNNIILSKIPYLRNYMVIKDENDNHIIDSFNIRQDTMNVVPKIFIDNIYIVDPTFQLLNMIKMFSQIDRLEDLSKDPEKFNARMATMLEYVRYTHGIVFDGKRNNMPMKCIIDENNRIVTVTTKDYFSFKKCLVYLDENVLSSDILDLNADTSCDFESVTNSVYLIHDNIMYTYFSNTILLSDKGKVHEISARGLCAHILLYQMLTSGEYKQCLSDLLNSMMNRDKIPIYSHTERDKKPGRHGFINIEKDIIVF
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.
What are the official names of this protein?
Poly(A) polymerase catalytic subunit, Poly(A) polymerase large subunit, PAP-L.
What is the protein family that this protein belongs to?
Belongs to the poxviridae poly(A) polymerase catalytic subunit family.
Protein: RS4_AQUAE
Sequence: MGRYIGPWVKLDRRFGVVVSGKKSAPKILARRNYPPGQHGRKYGRRKKLTEYGLRLMEKQKLKFLYGGLREKQFKKYFDMASKSKENTGEMLLQYLERRLDNVVYRLGFASTRRQARQLVAHGHVLVNGKKVNIPSYLVEPGDVIEIKEKSRDIPFIKENLENVDPRSIPSWLELDKDNFRGRVVRLPENVQEYLEIPINLQYIVEFYSKV
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RS15_ACIBY
Sequence: MALTNADRAEIIAKFARAENDTGSPEVQVALLTAQINDLQGHFKAHKHDHHSRRGLIRMVNQRRKLLDYLNGKDHERYTALIGALGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ENOPH_DROSE
Sequence: MSSGERVAKVVLVDIEGTTTSISFVHDVLFPYAKQNVEKFLRDFWKEDDIKHIVQDLQQVPKFADYKALLSAPPTEVDIELIAGFVRYLIDQDLKVTPMKTLQGLIWAQGYANGELKGHVYEDVPAAFEAWRAAGLRIAVYSSGSVAAQKLIFGHSLAGNLQPHLSAYFDTHVGHKQEQQSYENIAKQLKEDPKQILFLTDIPGEAAAACSAGLQAIILQRPGNAALADDQKASFELIPDFKPLHNLKLPINKSQA
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SRDB_NEUCR
Sequence: MSTSGPITEFPAPGLRDPFRYITGHDAEGNAVFVQTDNGDHRAVMLGGAAAQNIIYSAGSNPIELTGNVDLEFAKNRPSLHIPNGVCVRMIDFAPGCKSNMHRALCMGIGTVCEGEVELTLGSGEKRILRPGDVSINRGAMHQWRNTSDEKPARMLYTLLDIKPLIVNGKQLDFDMGYLMKEYAEYDEGEGDKKAE
What is the function of this protein?
Cupin-domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040).  The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040).  SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040).  The polyketide chain is then reductively released as an aldehyde (PubMed:30908040).  The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040).  This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040).  The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040).  This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
What are the official names of this protein?
Cupin-domain-containing oxidoreductase srdB, Sordarial biosynthesis cluster protein srdB.
What is the protein family that this protein belongs to?
Belongs to the virC family.
Protein: RT07_BETVU
Sequence: MGGLDSEQKQLIKKLVNFHMKEGKRTKVRAIVYQTFHRLARTEGDVIKLMIDAVENIKPICKVEKVRVAGTIYDVPGIVARDRQQTLAIRWILEAAFKRRISYRISLEKCLFDEILDAYRKRGISRKKRENLHGLASANRSFAHFRWW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 18S rRNA where it nucleates assembly of the head domain of the small subunit.
What are the official names of this protein?
Ribosomal protein S7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DEN6B_MOUSE
Sequence: MEVPVGPGPRQAGGGLGATRSSSSGRAARTAEMPWARFSAWLECVCVVTFDLELGQALELVYPSDFRLTDKEKSSICYLAFPDSHSGCLGDTQFSFRMRQCGGQRSLWQVDDRSYNNKAPLALQREPAHYLGYVYFRQVKDSSVKRGYFQKSLVLVSRLPFVRLFQSLLSLIAPEYFEKLAPCLEAVCNEIDQWPAPVPGQTLNLPIMGVVIQVRIPSRVDKLESSPPKQCDQENLLPAPVVLTSVHELDLFRCFRPVLTHVQTLWELMLLGEPLVVLAPSPDVSSELVLALTSCLQPLKFCCDFRPYFTIHDSEFKELTTRTQAPPNVVLGVTNPFFIKTLQHWPHVLRIGEPKMSGDLPKQVKLKKPSRLKTLDTKPGLYTSYTAHLHRDKALLKRLLKGVQKKRPWDVQSALLRRHLLELTQSFIIPLEHYMASLMPLQKNITPWKSPPQICPFRQDDFLRSLEHAGPQLTCILKGDWLGLYRRFFKSPHFDGWYRQRHKEMAQKLEALHLEAICEANIEAWMKDKSEVEVVDLVLKLREKLVRAQGHQLPVKEVTLQRAQLYIDTVIGSLPKDLQAVLCPP
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for RAB14.  Also has some, lesser GEF activity towards RAB35 (By similarity).
What are the official names of this protein?
Protein DENND6B, DENN domain-containing protein 6B.
What is the protein family that this protein belongs to?
Belongs to the DENND6 family.
What are the subcellular locations of this protein?
Recycling endosome. Cytoplasm.
Protein: GRP23_ARATH
Sequence: MGLISGKVCVFIFVFALVAEFSFGNVEVNDDKHFFHKPRPFLHKPRPFLHKHGIYKKGFGKGLGGGGGLGGGGGLGGGGGLGGGGGLGGGGGLGGGGGLGGGSGLGGGGGLGGGSGLGGGGGLGGGGGGGLGGGGGLGGGAGGGYGGGAGGGLGGGGGIGGGGGFGGGGGGGFGGGAGGGFGKGIGGGGGLGGGYVGGGHH
What are the official names of this protein?
Glycine-rich protein 23, AtGRP23.
Protein: TTCA_LEGPC
Sequence: MSSNPSSVEKKLLHYTGKAIADFNMIRHGDRVMVCLSGGKDSFTLLTILNQLRIKSGNKFEIFAFTLDQAQPGWNDACLRQWLAEKSIPHEILTRDTYSIVKEKIPEGKTYCSLCSRLRRGIIYRYAEENGFNKIALGHHRDDLIRTLMMSILYNGDIRSMPPKLLSDNKKHIVIRPLCYVQEKDIITFASEQAFPIIPCNLCGSQENLMRKKVASLIDQLAIENPKVPSNMLHALQSLKPSQLMDQNFWNFKNLEDGLETAQSVQCEEVFNAQEFEFEDEKI
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_MYCS5
Sequence: MRKLGIDFGLSRIGFAISDESNSFSLALENFDYDGSYEKIIQKIQLFLDEYKIDKFIIGYPLNSRGEKTKTCLLIDEFIIHLEKNFDQKIKLINESYSSRKASEILHQANIKNKKQKDKKDMLAAKIILQDYLDLYK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPR_BACC4
Sequence: MKSGEKDYSVKEAMIFSQRIAQLSKALWKCVEKDWQQWIKPYDLNINEHHILTIAYHLKGASISEIAKFGVMHVSTAFNFSKKLEERGYLVFSKKEDDKRNTYIEITDKGEELLLRLMEEYDPENNSVFNGALALRNFYGKFPENIELIAILRNIYGQDFIDIFEKSLEDIEENFTESDQKLVKK
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: REP_CLVN
Sequence: MRTPRFRVQAKNVFLTYPNCSIPKEHLLSFIQTLSLPSNPKFIKICRELHQNGEPHLHALIQFEGKITITNNRLFDCVHPSCSTNFHPNIQGAKSSSDVKSYLDKDGDTVEWGQFQIDGRSARGGQQSANDAYAKALNSGSKSEALNVIRELVPKDFVLQFHNLNSNLDRIFQEPPAPYVSPFPCSSFDQVPDELEEWVADNVRDSAARPWRPNSIVIEGDSRTGKTIWARSLGPHNYLCGHLDLSPKVFNNDAWYNVIDDVDPHYLKHFKEFMGSQRDWQSNTKYGKPVQIKGGIPTIFLCNPGPTSSYKEFLDEEKQEALKAWALKNAIFITLTEPLYSGSNQSQSQTIQEASHPA
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep, 40.4 kDa protein, Protein AC1, Protein AL1.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: LEU1_HAES1
Sequence: MQNNIIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSAGDFESVQTIARHIKNSRVCALSRAMDKDIDIAADALKVAEAFRIHTFIATSALHVEAKLRRTFDDVVEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGFCLPTEYGNIINQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQNDYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAFVQVELDGKKISQVSNGGNGPVDAVYNAILAITDMDITMLHYNLTAKGEGAEALGQVDIVVEHKGRRFHGVGLATDIVESSARALIHAINAIYRANKVADLKSHKISQ
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: C2_BCTVC
Sequence: MENHVSLKVVSPALYYAIQDLRAHTNNFLKNQKMKPLSPGHYIIQPSANSKVRSLITKQQHPRKVTLPCNCHFTIHHECNRGFSHRGTYYSPSGNKFRGIRECTESTVYETPMVREIRANLSTEDTNPIQLQPPESVESSQVLDRANDNRIEQDIDWTPFLEGLEKETRDILG
What is the function of this protein?
Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway.  Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense.  Determines pathogenicity.
What are the official names of this protein?
Protein C2, Protein L2.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae transcriptional activator protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: DF241_ARATH
Sequence: MRYTTSFIVFCFLIFLQTNLVKGRTIRICDRKVEGNGTCGPNSNNICLDEFWKNPPSPRLAKSLEGCTCEPRGKRPKFKGLSHVCWCCWSYNSSNPAG
What are the official names of this protein?
Defensin-like protein 241, S locus cysteine-rich-like protein 19, Protein SCRL19, SCR-like protein 19.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: FMP33_YEAST
Sequence: MLYTRLLRHNSQFTKFSGTSPNLGSKPLFSKGNLYTSLLVTTLYGTGLACLYLESNSLNKSKEQEDPHAIAEDDIVNIVHDAPNRIFKPALDTYQEKELDLQKSDLHKVLHSLTYSDVSQFSIVWGFLIQLSSLIGNSTLGKKSILYKGSVVSVLGFPPLIYMALKLRMKQLEKAGVRFE
What are the official names of this protein?
Mitochondrial membrane protein FMP33.
Protein: LUXS_DEIGD
Sequence: MANVESFDLDHTKVQAPYVRLAGVKTTPRGDQISKYDLRLLQPNRGAIEPAALHTLEHLLAGYLRDHLQNVVDVSPMGCRTGLYLAVIGEPDEEGVLQAFEAALRDTATHDRPIPGVSELECGNYRDHDLQAARQYARDALTQGLKVQKTILLQR
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PRMA_STAS1
Sequence: MNWTEVAIVANHEVSPIITNLLEDYGSNGVVIEDSEDLTHDFEDKYGEIYALNAEDYPTQGVRVKAYFNEIKYTKDFQEKLIQSLKDIESLDLDLFSFDEQTIREQDWENEWKHYFHPFRASEKFTIVPSWETYQQEDDSELCIELDPGMAFGTGDHPTTSMCLKAIEAYVKSSDSVIDVGTGSGILSIAAHLLGVKRIKALDVDEMAVRVAKENFQKNNCEYAIEAVPGNLLKEETEKFDVVIANILAHIIEEMIDDAYNTLNKDGYFITSGIIEEKHEAIVEHMKRSGFEIVSINHDNSWVCIVGQKVSD
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_BACAC
Sequence: MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EUTC_ECO5E
Sequence: MDQKQIEEIVRSVMASMGQTAPAPSEAKCATTTCAAPVTSESCALDLGSAEAKVWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTLALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RF1_MYCA1
Sequence: MTQPVQTIDVLLAEHADLERRLSDPDLHSNPDEARKAGRRFARLAPIVGTYRKLMAAREDLETARELAADDDSFTAEVADLESRVAQLDTQLTDMLAPRDSHDADDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWTVTVLDEITSDLGGYKDATLSIRSKGDSADGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVAEVQIDESDLRIDVFRSSGKGGQGVNTTDSAVRITHLPTGVVVTCQNERSQLQNKARALQVLAARLQAMAEEQASAEASADRASQIRTVDRSERIRTYNFPENRITDHRIGFKAHNLDQVLDGDLDALFDALAAADKQSRLQQA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_STAAW
Sequence: MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFNNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLLNTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RAVA_ECOLI
Sequence: MAHPHLLAERISRLSSSLEKGLYERSHAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFQNARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTSGYLPEAEIVFLDEIWKAGPAILNTLLTAINERQFRNGAHVEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKANFRSMLTSQQDENDNPVPDALQVTDEEYERWQKEIGEITLPDHVFELIFMLRQQLDKLPDAPYVSDRRWKKAIRLLQASAFFSGRSAVAPVDLILLKDCLWYDAQSLNLIQQQIDVLMTGHAWQQQGMLTRLGAIVQRHLQLQQQQSDKTALTVIRLGGIFSRRQQYQLPVNVTASTLTLLLQKPLKLHDMEVVHISFERSALEQWLSKGGEIRGKLNGIGFAQKLNLEVDSAQHLVVRDVSLQGSTLALPGSSAEGLPGEIKQQLEELESDWRKQHALFSEQQKCLFIPGDWLGRIEASLQDVGAQIRQAQQC
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYR_MYCTU
Sequence: MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: S72L3_HUMAN
Sequence: MLSSPLRVAVVCVSNVNRSMEAHSILRRKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKQMYNDLLRKDRERYTRNGILHILGRNERIKPGPERFQECTDSFDVIFTCEESVYDTVVEDLCSREQQTFQPVHVINMDIQDTLEDATLGAFLICEICQCLQQSDDIEDNLEELLLQMEEKAGKSFLHTVCFY
What is the function of this protein?
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.  Plays a role in RNA processing and termination.
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 3, RNA polymerase II subunit A C-terminal domain phosphatase SSU72L3, CTD phosphatase SSU72L3.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
Protein: MKROS_HUMAN
Sequence: MHCAEAGKALIKFNHCEKYIYSFSVPQCCPLCQQDLGSRKLEDAPVSIANPFTNGHQEKCSFLLRPTQGTFLREYDGRSDLHVGITNTNGVVYNYSAHGVQRDGEGWEESISIPLLQPNMYGMMEQWDKYLEDFSTSGAWLPHRYEDNHHNCYSYALTFINCVLMAEGRQQLDKGEFTEKYVVPRTRLASKFITLYRAIREHGFYVTDCPQQQAQPPEGGGLC
What are the official names of this protein?
MKRN2 opposite strand protein, MKRN2 antisense RNA 1, MKRN2 antisense gene protein 1.
Protein: TIG_AZOSB
Sequence: MQTTQEIQTSQNPLERRIDMSLAVADIDKAVEARLKQMARSVKMPGFRPGKVPLKIVEQTYGPQARSEAIGAAVERAFGEKVREQNLRVAGYPRIEPKEAGSEGALEFSAVFEVYPEVVVGDLSAQSIEQPTLVVGDAEVDKTIDVLRKQRTTFEAAARPTQDGDRVTIDFAGRKDGELFEGGQATDFPFVIGAGSMLKDFETAVVGLGVGETKTFDMTFPEDYHAKHLAGQPVQFEVTLKSVEAPKLPEVDSDFAKALGVADGNVDKLREEVKGNLEREVKRRIQAKVKEQAMDALLAVTPIEVPKALVESEATQLAENAKRDLAARGMNTKDIPVQPAWFGDQAMRRVKLGLIMAEVVKGNELHAKPEQIRGLVEEMAQSYEDPSELVRWYYAQPDRLAQAEAVVIEDNVVAWVLSKAQTSEKSIAFDDLMGNAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: OAT_BACC3
Sequence: MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTARRWAYDVKKVEANRAEIIVCEDNFHGRTMGAVSMSSNEEYKRGFGPMLPGIIVIPYGDLEALKAAITPNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGRTGKVFACDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAGLLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase, OAT, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_KORVE
Sequence: MPRTRKKVEVKVAPKGAKLQLKWIRSAIQAPVKHKLVIKGLGFTRLNQVIVREDSPSIRGMVAKVPHLVEIVQQ
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.