PharMolix/UniProtQA huggingface dataset:
Protein: FOXA2_HUMAN
Sequence: MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASPLAADTSYYQGVYSRPIMNSS
What is the function of this protein?
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.  Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites.  Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).  In embryonic development is required for notochord formation.  Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles.  Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc.  Interacts with the cis-acting regulatory regions of these genes.  Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis.  Involved in regulation of fat metabolism.  Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
What are the official names of this protein?
Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Protein: ISPE_IDILO
Sequence: MAVNILTLPAPAKLNLFLHIIGRRSDGYHNLQTVFQFLDYADTLKFYTAADDKFDLIDHDSHIPRDENLVWKALTALRKTYEEKGITQLPGCSIELIKRLPQGAGLGGGSSNAATALVGLNQLWGSHLNSTELQAIGRKLGADVPVFIHGHACFAEGIGDVFTNITPPTPWYLVVKPNVSISTAALFSHPKLERNCSPVTADNWQQQKVANVFEPVVCDLHTEVAMLRRALLEYAPTRLTGSGACLFSTFETRQAAKEAQQQVPKELCSFIAQGQNRSPLIQTLTQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ZAPB_SERP5
Sequence: MSFEVFEKLESKVQQAIDTITLLQMEIEELKDKNNTLSQEVQAASGNHESLVRENQQLKEEQHVWQDRLRALLGKMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: BIOD_STAES
Sequence: MNIFVTGTNTDIGKTYVTKYLYKALRTRGYRVCIFKPFQTEEIGGGRYPDLEIYKNECDLDYDVTSLYTFKDPVSPHLAFKIERHQQLNHQTMIDKLESLKAQFDMILIEGAGGIAVPIYEYSDHFYMTTDLIKDTSDFIVSVLPSKLGAINDAIVHQKYIDHQELPPNVLIMNNYTDSAIEQDNLHTIEKLIHKSVYTLGHQATQESFSEAFIQRIIGGSNG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLPA_YERPE
Sequence: MRKEWLWVGIASVLLSACIDQPPAPQQQVQQTYSGPVEEIGGAEPRYEPFNPNVNQDYKVNGQSYRIIKDPQNFSQIGLASSYGEEARGNTTATGEIFDPNALTAAHPTLPIPSYVRVTNVSNGRQIVVRVNDRGPYTPGRVIDLSRAAADRLNISNNTKVKIDFINVAPDGSLSGPGMVGTTIAKQSYALPSRPDLTSSGMGTPMQQDAPATGAAVQAIDNSQLSGTDATQPVASQSSGFLRAPTPVPAGVLESSEPVIDSAPVTPPVVANPGPVTTTPTSSAISGGYVVQVGALSDAQRAQSWQQSLSQRFGVPGKVSNSGSIYRVQLGPFSHRQQAVDLQQRLSNEAQQQSFIVAAP
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA, Rare lipoprotein A.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: IXTPA_GEOSL
Sequence: MTRLVVATRNKGKLREIAAILDGLPFTLLSLEDFPDFPEVEEDGKTFEENALKKASVAANITGLPALADDSGLVVDALDGKPGVYSARYSGENASDEANNAKLLSELESVPYEERTAAFRCTIALCSPGGKRYTFSGELHGVILDSPRGTGGFGYDPLFFVSEKGATMAELPLEAKNAVSHRGRALALLKDHLGWQGIE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: APT_ACIET
Sequence: MTALSVNDYLRQHIRTVPDWPAPGVQFRDITPLLQNPKVFRVLIDAFVHRYMDRALRPDVVAGLDARGFILGAVVAYELNVGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVQPGDRVLLIDDLIATGGTMMAGKKLLEKLGATVMEGAAIVDLPELGGSARLRASGLPLYTLVDFSGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ALBFT
Sequence: MYNRNILIEQTDPEIFAAIAAENARQEQHIELIASENYASPAVMAAQGTQLTNKYAEGYPGKRYYGGCEFVDIAEQLAIDRVKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMERKAHESKPKLIIAGASAYSLRIDFARFAKVAKDVGAIFMVDMAHYAGLIAAGIYPNPVPHADVVTSTTHKSLRGPRGGIILMKAQHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALQPEFKVYQQQVLTNARVVAETLVSRGLRIVSGRTESHVMLVDLRSKSITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKDEEARITANLIADVLDNPRDSANIDAVRAKVNALTKRFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GDF8_GORGO
Sequence: MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_MARPO
Sequence: MLNLRIMAPNRIVWNSDIQEIILSTNSGQIGILPNHASVLTALDIGIVKIRLNDQWSTMALMGGFAMIDNNNLTILVNDAEKASEIDYQEAQETFQKAKTNLEEAEGNKKKEIEALLVFKRAKARLEAINMASKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL13_AQUAE
Sequence: MKTYRIKPEEVERKWWVVDATGKTLGRLASEIAKILRGKHKPYYQPDVDCGDFVIVINAEKIRVTGKKLEQKKYYWHSRYPGGLKERTLKWMLENKPEEVIRLAVKRMLPKNRLGHRMLKKLKVYRGPEHPHQAQKPQPLEVKA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: KPYK_METJA
Sequence: MVGMMRKTKILVTLGPSLENKLDKAINLIDGVRFNMSHATTDYCEKFLNILEKNNIAKVMDLKGIKIRIKEVKLKNKILKMGEKVVIGEDIKLNYNIDTIEEGHFILINDGKIKLRVVEKTDKIIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFGDRVCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKEIGKGIYLITLGHPIGQKKTNTIKVESI
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
Protein: RT18C_HUMAN
Sequence: MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQLLSQFVSPFTGCIYGRHITGLCGKKQKEITKAIKRAQIMGFMPVTYKDPAYLKDPKVCNIRYRE
What are the official names of this protein?
28S ribosomal protein S18c, mitochondrial, MRP-S18-c, Mrps18-c, S18mt-c, 28S ribosomal protein S18-1, mitochondrial, MRP-S18-1, Mitochondrial small ribosomal subunit protein bS18c, Mitochondrial small ribosomal subunit protein bS18m.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MTND_NEUCR
Sequence: MKAYFYDNLPGDQRLPHDSGKEVTVAELEKVGVLYFRFPDVEGVNTLAAERGYKNRDEIIVSPEKMGAIYETKVRQFFDEHLHEDEEIRYIRDGAGYFDVRNEGDEWIRIKLVKDDLIILPAGIYHRFTTDDTNYIQAMRLFKEEPKWTPLNRTEGLDENPYRQEYVTQFLKAQAEQA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: METXS_BURVG
Sequence: MESIGIVAPQTMHFAEPLRLQSGSVIGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGIYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSDDPSTGQPYGARFPVVTVEDWVHAQARVADAFGIDRFAAVMGGSLGGMQALAWSLMYPDRVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGNYYAHGVKPKRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFSFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFDGNLTAALAHTQAKYLIASFSTDWRFAPARSREIVKALLDNKRTVSYAEIDAPHGHDAFLLDDARYHNLIRAYYERIANEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPE_CHLTR
Sequence: MREEAMKKQGVLVAPSIMGADLACIGREARNIEESGADLIHIDVMDGHFVPNITFGPGVVAAINRSTELFLEVHAMIYTPFEFVEAFVKAGADRIIVHFEAAENIKEIISYIQKCGVQAGVAFSPETSIEFVTSFIPLCDVILLMSVHPGFCGQKFIPDTIERIQFVKQAIQVLGREGSCLIEVDGGIDKESARACREAGADILVAASYFFEKDSINMKEKVLLLQGEEHGAK
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
Protein: RL33_BUCAP
Sequence: MAKKNREKIKMISSAGTGHYYTTTKNKRNTPDKLKLKKYDPIIRKHILYNEGKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: COF_CROS8
Sequence: MARLGAFDMDGTLLMPDHQLGEATQMALHRLHQRGVTLAFATGRHLLEMRQMLQKIALEAFLITGNGTRIHAPSGELLFAEDLSPQVAEAVLHGYWDTSASLHVFNDSGWLTDNDDPALLDAHAWSGFRYQLTDLKRLPAHQVTKICFVADHDALCELRVKLCQTLGSQAHICFSALDCLEVLPPGCNKGAALQALSQHLGITMADCMAFGDAMNDREMLSLAGKGLIMGNAMPQLLAELPHLPVIGHCSRQAVAHYLTHWLDHPHLDYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: Y118_BORBU
Sequence: MYILFSVLALSFIIFIHELGHFLFAKLFKVKVEVFSVGIGPSILKFKINNTEYRLSPILLGGYCKLKGFDHLEKELKANKELEADKDSLFGISHFKKILIYFAGPLFNLIFSFIVFIFISMAGVIYFDYSSRVSILNKDSLLKDKFRDGDVILKVNDKKIKYFSDLRKFIPEEKSTVMFDVLREKENITFKETVSLQDFLKEIGPWADLVIADVVSNSPAKIAGMKPGDEIISIDNVILKNKRDLDYFLKNLNSDVVEIKFSRNGEIFSSKLVFHDKNKMIGIYFSPPLKRVVKVENVSSAIKNSFFKVVSALQDILYSIFLLMTNFLNASKSVSGPVGIVGILSSSYSLGILYWINSISFLSLILAGMNLFFIVIPIFDGGQIFISFIELLRGKRFKAKTIYSFYSFGIFFGLFLFGLGLFNDLKGLLNIFN
What are the official names of this protein?
Putative zinc metalloprotease BB_0118.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL29_UREPA
Sequence: MSSIAQDLRKKDSLELEKIVIELKAKLLELRFAAANGEAEKLHTAKEIRKTIARALTILNERELAEKLNNKEANK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: LTOR5_NEMVE
Sequence: MEKDLESHVDDVMSEHGVVGVMCTDDQGLSLIAKGTANPATAGFVQNLAESARKLYPDSEQQPVICLESDACNLLIKSQNKVTIAVHKVPS
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR5 homolog, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR5 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome.
Protein: PSBJ_TETOB
Sequence: MSNTGTTGRIPLWLIGTFVGTAALGILAIFFYGSYVGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HLDD_YERE8
Sequence: MIIVTGGAGFIGSNIVKALNNIGYKDILVVDNLKDGTKFVNLVDLDIADYMDKEDFVASIVAGDDMGDIDAIFHEGACSSTTEWDGKYMMDNNYQYSKDILHFCLDRGIPFLYASSAATYGGRTDNFIEDRQYEQPLNVYGYSKFLFDQYVREILPQADSQICGFRYFNVYGPREGHKGSMASVAFHLNNQINAGENPKLFSGSENFKRDFIYVGDVADVNLWFWQNGVSGIFNCGTGRAESFQAVADAVVDFHQSGPVEYIEFPEKLKGRYQAYTQADLTNLRAAGYDKPFKTVAEGVKEYLTWLNRSV
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: RS5_LEGPH
Sequence: MSFDELPKSDGYQEKLVSVTRTAKVVKGGRVFGFAVLVVVGDGKGKVGFGRGKAREVPIAIQKAMDQAKKNMVYIPLSGTTIFHEITWNYGASKVFMKPASEGTGIIAGGAMRAVLEVLGVQNILAKSIGSTNPSNIVRATIGALTHIGTPDYVAAKRGKTVEEVMAG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: IMDH_KORCO
Sequence: MRIDRFEFAFTFNDVILLPGKTEIEPSNVDLTTRIGNIALSIPILSSPMDTVTEEEMSIAMARMGGLGILHRNCSVEEQVNMAKAVKRAESFIIRDVITVSPEDSVEEARRLMREHGISGLPVIVGRKLVGIVTRRDVYFAENGSLLVKDIMTKDPITVGPEITPQEARKIMARYKIEKLPVVSESGELIGLVTAKDVFYRESHPFATRDEEGRLRVGAAISPFDIDRAKTLAPYVDVLVTDVAHFHNENVISATKRIIDEVGVPVIAGNIGTYEAAEEAITRLDIIGLRVGIGSGSICTTGEVTGVAAPTLYAVASASEAVRKYSKDVAVIADGGIRGPGEAAKAFAMGADAVMLGYALAGTKEAPGSTMMIGGKMYKIYRGMGSPSARSKRFAMDRYSKPSKDIAEGIEGLVPYRGDVTTVVDRFVAGLKAAFGYVGAANISEMKSKARVALISHSGMSEIAPHDVKPLEKISD
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: P4KG7_ARATH
Sequence: MSRNLDSPVQTQMAVAVFKTPLTGASKMEGKQHHKHQHLQRQSSGRRVFVQTETGCVLGMELDRSDNVHTVKRRLQIALNFPTEESSLTYGDMVLTNDLSAVRNDSPLLLKRNFMHRSSSTPCLSPTGRDLQQKDRSGPIEILGHSDCFSIVKHMVKDIVKAMKMGVEPLPVHSGLGGAYYFRNKRGESVAIVKPTDEEPFAPNNPKGFVGKALGQPGLKSSVRVGETGFREVAAYLLDYGRFANVPPTALVKITHSVFNVNDGVKGNKPREKKLVSKIASFQKFVAHDFDASDHGTSSFPVTSVHRIGILDIRIFNTDRHGGNLLVKKLDGVGMFGQVELIPIDHGLCLPETLEDPYFEWIHWPQASLPFSDEEVDYIQSLDPVKDCDMLRRELPMIREACLRVLVLCTIFLKEASAYGLCLAEIGEMMTREFRPGEEEPSELEVVCIEAKRSVTERDVFSPRSDVVGEAEFQFDLDCDDLESVYSSKIQLTDDYFTKNPFSNGRSSLGKLEESIKEEEEDEEEEEDKTENTVPMIIMKDSFFSSAAFHDKAPSLSKLSTSMKNTHLSDTTRKNPKPLTRGKSENTSSGHKSANEQLPVSASFVKVADMKEDEWVLFLERFQELLGPAFAKRKTATLSKRQRLGTSCQF
What is the function of this protein?
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity).  Undergoes autophosphorylation and phosphorylates serine/threonine residues of protein substrates (PubMed:17880284).
What are the official names of this protein?
Phosphatidylinositol 4-kinase gamma 7, AtPI4Kgamma7, PI-4Kgamma7, PI4K gamma 7, Ubiquitin-like domain kinase gamma 7, UbDK gamma 7.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
Protein: PXPA_STAAC
Sequence: MRVDLNCDLGEAFGNYSFGGDHQIIPLITSANVACGFHAGDENVMNETVKLAKAHNVAVGAHPGLPDLKGFGRRNIDISNDEIYNLMIYQLGALQGFCRIHQVKINHVKPHGALYQMGAKDREIANVIAQAVYDFDPSLVLVGLANSYLISEAKNVGLITASEVFADRRYEDDGQLVSRKESDAVITDTDEALKQVLKMVKENKVISKNNKEVTLQADTICVHGDGEHALLFVSKIREILMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: CONV_CANCT
Sequence: ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNSTHETNALHFVFNQFSKDQKDLILQGDATTGTDGNLELTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFDATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN
What is the function of this protein?
D-mannose/D-glucose-binding lectin which binds alpha-methyl-D-mannoside, D-mannose and D-glucose in that order (PubMed:24519628, PubMed:27737777).  Also binds to serum fetuin and ovalbumin (PubMed:24519628).  Has hemagglutinating activity towards rabbit erythrocytes (PubMed:24519628).  Is not toxic towards larvae of the brine shrimp Artemia (PubMed:24519628).  Induces relaxation in rat endothelized aorta (PubMed:24519628).  Shows a transient edematogenic effect in rat (PubMed:27737777).
What are the official names of this protein?
Concanavalin V, ConV.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: KRR1_DROGR
Sequence: MSDSETEETTKQSTEPVDNAWSLKIPTFKAEDNPHGMVEESSFATLFPKYREKYLKEVWPLVQQTVAEHHLRAELDLIEGSMVVKTTRKTWDPYIIIKSRDMIKLMARSVPFEQAKRVLQDETGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVAALGPYKGLQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPQLANEDWSRFLPKFKNKNISKRKQPKSRKPKGEYTPFPPAQPESKIDKQLASGEYFLNKEQKQAKRQQERVAKQAEAAKKQDERRNKDFMPPTEDSPEQNRKRPSEASKVDVKALKAKLLKANKQK
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.  Binds to RNA.  Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development (By similarity).
What are the official names of this protein?
KRR1 small subunit processome component homolog, KRR-R motif-containing protein 1, Protein dribble.
What is the protein family that this protein belongs to?
Belongs to the KRR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.