Protein: MALG_MALAU
Sequence: MSDDPLLSSPTEAICLNHSVTDLRLAAALKLSWTFLLAHYSGSSEIPLDIRLEYRYIDGSETNFEPFDATFEVDKKSLIEDSIGMIQNMLTPSTRPHSLSNGINSSQSDKHVPEAQVSFTFSSGSRPVLEKGATTRYAATVLELECLQGLKKEYLCRINFNRMMWNVEEATGILRQFRHIAQQIVSADVCATLSQINLMCESDIEQLKRWNSTVPDPVLACIHELFSEQAKKNPTATAVQTSEGSFDYGRLDELSSALACHLSSNGLTRGTPVPLLFDKSMWMVVATLAVLKAGATCVSICTGLPTKAIEDILEQTAAQLVLVSESQGLRLSETRTQVVSDKTMQIWHTMSGKPELPQSDPTDLACIIFTSGSTGKPKGIMLDHIALVTSIRNHGPSLGISSSSRALQFSSYAFDMSFYETYTTLLSGGCICIPSETERLNSLPQFICDHNVNWAFLTPSVLRDFHPSEFPSLRTLATGGEPVGADIANEWAGRLQLFNLWGPAEATICATGPILPGVWIPGTFGKAVGCIAWITQAENPDELVPIGAVGEVLIEGPVLAQGYSGDVEKTKASFIPFPKWRERFELTPRGRVLFRTGDLAQYNPDGTIRYVGRMGTVVKVGGQRVDIDAVEYALRRIDRSSHIAVEAVELEKETGQGPTLIAFLSSDMNGVSGSEKKRCCSIDPGSRSWEAWANIAIRLQDTLAGVLPRYMIPHLFIPVSTIPTTPSGKANKRQLQALVLGQSKAHLLQLCRQRSPDASYPEQHLTENETLLRLLVSDVLGIDRDHVAMNSRFFHLGGDSLAAVKLVALARQQGIQLKVEAILQSCSLREAAGTMISAGEKQKLQSKTSFAINKCDDKLGLLEEATVQCGISESDIEEIYPSTPLQEGLITVTSTFSASKPYVDKILFTLSATADLDRVRDAWNHVVAANDILRSRIILSPAGKAFNVVVRSEPSWQYYKTVQQYLENDNAQDMTFGKELITFNLIASHDQSASARSIGITIHHALYDNWTVSLLHKQAEDAYRGELVEPCSFSTFSHYVLQQSPDINKEFWRKQFLDLRAGTFPELPSSDYVPRANSSSQHLYKGQHQRRDFSMATNIQLAWALLLSLYTNSPDVVYGLVVNGRMAPMPGVGGLVGPTIATVPFRTTVERSMSVQAALEAIQKRVLSIVPFEQTGLQNIARMGEGPKTACNFQNLLVIQQDLEFKGEGIFCRRQNLVGAVNNFPGYGIILLCSATEHGWAFEILYSNSLIPETRARRILLQLDHLLRQLEVDPYRQLAQLELLCPSDKSKLTSWNTQLPIRVNACIPEVFGAQCLVRSERTAVSAWDGSLSYRELDRFSSIVARHLQAVGVGKGTITPILFEKSRWVVVAMLAVLKTGAAFVMLDTNQPLQRKQGICRAVRATTIATSASCAHESKVLANSIYVLDEASITKTDTNQFLPLVEVSPNDLAYVVFTSGSTGEPKGVLIEHASSCSASRAQAAKLGISPDSRVLQLSSYTFDSFAVEILASLLAGCCICIPSESESSNDIAGAVRRFSATWLCITPSVLGLTNPDEVPSLKTVVAVGESARPSQIRLWSTRVNFICGYGPSECSTGASAQLIRSAGSDPRIIGSGMGSCLWVAHTDDHNVLVPIGAIGELLIQGPIVGRGYMNSPEKTRAAFLESTAWIPEFRQVATERFYKTGDLVRQNEDGSIVYLGRKNREVKLRGQRLDLEEVENQLSAALEMDINIVAEVVKPKGVDSQPVLIAFFQVVADVELRSDNITFLELNPDIGLRLLDAEEKLRKILPPVMIPSVYLQVQRMPLTMSGKMNRQALRNKASTRTLSQLFSSGSVRHEDDYLTLQPHESTALFVCQAICGIMRDKIDDTKTLIAGKNVNLSRTGMDSIDAMMLARTISRHFGITLSIRAFLGSSVTVRDIARLIEGVKSEDNLSQFDLYAKYESIWEELRGVVRGLTPSDKPQLCDKTPAGMSVFLTGGTGFLGTHILRQILQDPRVELVTVLTRAESPAHALSKIVESAKIAQWWQESYRNRIDAWVGDLARPRLGLSDDHWARLCGYGEHKFTSIIHNGAAVHWGYDFEKLKPVNVMSTFWLLVSLFIAGPLVNFTYVSALLPECDGLTDREIALKTSDDGYSQTKYVSELLVKNFKEQLCNNPIAIVRPGLLIGSAEHGVANVGDYLWRVVSSAFSVGAYISEKGDAWIYIAAVDWVANQVIREALYESTTDLRIINVTDGLTVKEFWRAIQIASPRQLNALQSEDWLSLIRQQLDVTGKSHPLWPVISFLESSKGCLGFSHNLPPQAHSLSSMIITALIKNVRYLASLGLVSWTTTGSNCDHSVQQRIFRRVL
What is the function of this protein?
Nonribisomal peptide synthase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353, PubMed:31548667, PubMed:28777910).  The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading (PubMed:23213353, PubMed:31548667).  This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE (PubMed:31548667).  The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway (PubMed:31548667).  Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2. 2. 2]diazaoctane ring of premalbrancheamid (PubMed:31548667).  Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide (PubMed:31548667, PubMed:28777910).  MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C (PubMed:28777910).  Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D (PubMed:28777910).
What are the official names of this protein?
Nonribisomal peptide synthase malG, NRPS malG, Malbrancheamide biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.