PharMolix/UniProtQA huggingface dataset:
Protein: ARGR_ECO27
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKELYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOBD_ECO24
Sequence: MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRVPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLVSTQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPOA_SOLLC
Sequence: MASLCSNSSSTSLKTPFTSSTTCLSSTPTASQLFLHGKRNKTFKVSCKVTNTNGNQDETNSVDRRNVLLGLGGLYGVANAIPLAASAAPTPPPDLSSCNKPKINATTEVPYFCCAPKPDDMSKVPYYKFPSVTKLRIRPPAHALDEAYIAKYNLAISRMKDLDKTQPDNPIGFKQQANIHCAYCNGGYSIDGKVLQVHNSWLFFPFHRWYLYFYERILGSLIDDPTFGLPFWNWDHPKGMRFPPMFDVPGTALYDERRGDQIHNGNGIDLGYFGDQVETTQLQLMTNNLTLMYRQLVTNSPCPLMSLVDLTLFGSTVEDAGTVENIPHSPVHIWVGTRRGSVLPVGKISNGEDMGNFYSAGLDPLFYCHHSNVDRMWNEWKATGGKRTDIQNKDWLNSEFFFYDENGNPFKVRVRDCLDTKKMGYDYHATATPWRNFKPKTKASAGKVNTGSIPPESQVFPLAKLDKAISFSINRPASSRTQQEKNAQEEVLTFNAIKYDNRDYIRFDVFLNVDNNVNANELDKAEFAGSYTSLPHVHRVGDPKHTATATLRLAITELLEDIGLEDEDTIAVTLVPKKGDISIGGVEIKLAIVKLVCVVNLLTLQLNKDRFCYDSVFVCWFVCLFFNFHV
What is the function of this protein?
Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
What are the official names of this protein?
Polyphenol oxidase A, chloroplastic, PPO, Catechol oxidase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: LDHA_LYCDA
Sequence: MSTKEKLISHVMKEEPVGSRSKVTVVGVGMVGMASAISVLLKDLCDELALVDVMEEKLKGEVMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCIIMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHLMGEKLNIHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQGLNPKMGVEGDSENWKAVHKQVVDGAYEVIRLKGYTSWAIGMSVADLVESIIKNLHKVHPVSTLVQGMHGVKDEVFMSIPCVLGNSGLTDVIHMTLKAEEEKQLVTSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_LIMF3
Sequence: MAKKRGKKYQDALKKVDSKKEYAVDDAVDLVKEIDFANFDATVEVAFNLNVDTKQADQQLRGAIVLPNGTGKDQTVIVFAKGENAKAAQEAGADFVGDQDLVEKIQDGWLDFDVAIATPDMMPQVGRLGRVLGPKGLMPNPKTGTVTMDVAKAVSDAKAGQVTYRTDRDGNVAVPFGKVSFDTAKLVENLKTIEDVVVKARPAAVRGTYIKHASIASTFGPSVTLDLTTF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: HIP6_ARATH
Sequence: MGEKKEETATKPQGEKKPTDGGITTVVMKLDMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNVDPVEVRDKVADKIKRPVELVSTVAPPKKETPPSSGGAEKKPSPAAEEKPAEKKPAAVEKPGEKKEEKKKEEGEKKASPPPPPKESTVVLKTKLHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGIIDVKQLTPYLNEKLKRTVEVVPAKKDDGAPVAAAAAAPAGGEKKDKVAGEKKEIKDVGEKKVDGGGEKKKEVAVGGGGGGGGGGGDGGAMDVKKSEYNGYGYPPQPMYYYPEGQVYGQQHYMMQGQSSQSYVQEPYSNQGYVQESYMNQGYGQGYGQEAPPPPYMNQQGYADPYGHMRAPELFSDENPNGCSVM
What is the function of this protein?
Heavy-metal-binding protein.  Involved in the maintenance of heavy metal homeostasis and/or in detoxification.
What are the official names of this protein?
Heavy metal-associated isoprenylated plant protein 6, AtHIP06, Cadmium induced protein CdI19.
What is the protein family that this protein belongs to?
Belongs to the HIPP family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: Y649_MYCPN
Sequence: MKISLSTSLFSIEQKVEYFNLNYQSLSDFSVVAKLNYTFTWYGNDFSIGFAPKKGEKLYFDLFFTFKASPNHPFAAENFKPDSEAIDFYVSFSWRLEGKDEVSKKLFELSVFGRARAFQIDDYKINLFSYLVYVIR
What are the official names of this protein?
Uncharacterized protein MPN_649.
What is the protein family that this protein belongs to?
Belongs to the MG439/MG440 family.
Protein: Y910_MYCVP
Sequence: MADNDRDGWDPASGVGLSATEGAAARAVVGRRKTPLVRDPFAEPLVCAVGVDSLTRLAQQSGVDGESGFAIPRMVDWIAARTRFFDDYFNAGQTDGIRQSVILGAGLDSRTYRLPWLPGATVYEIDQPGVVEFKNETMDRLQAQPLADRRPVAADLRGDWAPPLRIRGFDPSLPTMWSAEGLLPYLRAEDQMQVLDEISALSSKGSRLAADTVDDIGELAARIALSRGPRNPVAESDADLGGASSSHAVAQRLQSHGWLSNTRPAPQLFAAYAMPPLAEDQELYRKITVVTAMLR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mvan_0910.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: MTND_MOUSE
Sequence: MVQAWYMDESTADPRKPHRAQPDRPVSLEQLRTLGVLYWKLDADKYENDPELEKIRKMRNYSWMDIITICKDTLPNYEEKIKMFFEEHLHLDEEIRYILEGSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNRPADHFDARVQYMSFLEGTA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (PubMed:26858196).  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:26858196).  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (PubMed:26858196).  Also down-regulates cell migration mediated by MMP14 (By similarity).
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, MTCBP-1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Protein: SRRT_HUMAN
Sequence: MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation.  Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs.  Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex.  Involved in cell cycle progression at S phase.  Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.  Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal.  Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).
Protein: AFVD_ASPFN
Sequence: MQESLTSGSSASLNIHDKRFAALYELGGKITELFAKELISQSGLPWSSQEPLVVLDNACGTGAVSSVLHHTIGNDKKANWHLTCGDKSEDMLHYTRQKMLQEEWHNAEVKIVNAQDTRLPSAHFTHIFTAFAIWVCTLSAAITNLSGDLPAPSEKEIHGVYNVGWDEEASVRAKFEQAGFNDIKVRKVIKEYLVPVNQFVESCTILIPTIVNIFWTQDQRDQYESELPMAVHRYVEGKYGRDGMASMEAEAIIATGHKH
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C. hemipterus (Ref. 2, PubMed:26209694).
What are the official names of this protein?
Methyltransferase afvD, Aflavarin synthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: RS6_THEVB
Sequence: MITRNYETLYIIRPDVGEEQLEQTISQFRTFLEEQGATKLKVQNRGKRRFAYPIKKLREGYYILMTYTAPGTAIAPLERAMRLNENILRFMTIVLEEETETEDAEEENPVLARA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: TKTC1_ARATH
Sequence: MASTSSLALSQALLARAISHHGSDQRGSLPAFSGLKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYDSVQEEDLKQFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEVVDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTENVDQRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWEKALPTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHSPGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLPHLPGTSIEGVEKGGYTISDDSSGNKPDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSDEYKESVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFF
What is the function of this protein?
Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively (By similarity).  Could act as a stress sensor involved in adaptation process.
What are the official names of this protein?
Transketolase-1, chloroplastic, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: FAIM1_HUMAN
Sequence: MTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS
What is the function of this protein?
Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
What are the official names of this protein?
Fas apoptotic inhibitory molecule 1.
What is the protein family that this protein belongs to?
Belongs to the FAIM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_GEOSL
Sequence: MSQRGNRKTQVGVVVSDKMDKTVVVRVSHLVKHPVYNKYIKRSVKYKAHDTDNSCKTGDRVLIVETRPLSKDKRWKVRQIIDRVE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: NIP7_HUMAN
Sequence: MRPLTEEETRVMFEKIAKYIGENLQLLVDRPDGTYCFRLHNDRVYYVSEKIMKLAANISGDKLVSLGTCFGKFTKTHKFRLHVTALDYLAPYAKYKVWIKPGAEQSFLYGNHVLKSGLGRITENTSQYQGVVVYSMADIPLGFGVAAKSTQDCRKVDPMAIVVFHQADIGEYVRHEETLT
What is the function of this protein?
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
What are the official names of this protein?
60S ribosome subunit biogenesis protein NIP7 homolog, KD93, Nucleolar pre-rRNA processing protein NIP7.
What is the protein family that this protein belongs to?
Belongs to the NIP7 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RR7_CABCA
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPNIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DCW1_YEAST
Sequence: MLVNKVIGLLGVLFATRFTNAVELDLDNYESLQNATSLIAYGLMDYYTGNQYGKTVGMFSDPYYWWEAGGAWGCMLDYWFFMDNDTYNDEIIAAMIHQAGDDNDYIPLNQSTTEGNDDQAFWGIAAMTAAERNFTNPPENEPQWLYLAQAVFNTMALRWDADSCGGGLRWQIFVWNSGYDYKNTVSNGALFHIAARLARYTGNQTYVDWAEKVYEWMVGVNLISNGTYKYVYDGVSIDDNCTKVTSYQWTYNQGLLLAGSAYLYNFTGSDLWHTRTKEFLNASQVFFHDGIVYEAACQGPNSCNTDQRSFKAYFARFLGVTAQLVPETRNQIMSWLNTSAIAAAKSCSGGTDGHTCGLNWFNGTWDGMYGLGEQMSALEVMVNTRALDKPAPYTAENGGSSVGDGAAGTQAQPTNLAPLNITKGSKAGAGIITAVIGISIVACALWLVF
What is the function of this protein?
Required for normal synthesis of the cell wall.
What are the official names of this protein?
Mannan endo-1,6-alpha-mannosidase DCW1, Defective cell wall 1, Endo-alpha-1->6-D-mannanase DCW1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 76 family.
Protein: HDFR_ECOLC
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNALIRDLLKINVLDEVY
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: ENO_PELUB
Sequence: MSKILKIKARQVFDSRGNPTIEAEVYSKKLSASAICPSGASTGTYEAFEKRDDNNKKYLGKSVLGTVNLVNTKISKKLIGTNIHDQTRIDTILINLDGTRQKTNLGANAILAVSMAAKKLSAKIKNVPLYKTFLVKNNYKLPYPLMNIINGGAHANNGLRIQEFMIRPDKAKNFSEAMRICFVVINNLKKLIIKKGLSTSVGDEGGFAPMISNNEKALDLVVAAINKSGFKNGKDVSICLDVAANELMKKDKYSIHSKKFVSVDQSIKEYKKIINKYKIKSIEDPFGENDWMAWSKLMKNTNNVQIVGDDLYVTNLERLKKGFLNNSSNSILIKLNQIGTVSETLEVIKFAQIIGYKTIISHRSGDSEDTFIADLAVGTNSNQIKTGSLARSERVAKYNQLLRIEEELGKKASMSKIH
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: UVRB_ECO81
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHLLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_SAGMY
Sequence: VHLTGEEKSAVTTLWGKVNVEEVGGEALGRLLVVYPWTQRFFDSFGDLSSPDAVMNNPKVKAHGKKVLGAFSDGLAHLDNLKGTFAQLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FES1_ASHGO
Sequence: MDKLLHWSIANAQGDKEAAAKAGAPDPKLLQQLFGGGPDEPALMRDAMAVIMNPEATVDNKLVAFDNFEMLIENLDNANNIENMRLWAPLISILESEEEQLRECALSVVGTAVQNNEKSQSNFLKHDGAMKKIIELARKDSESEQVRTKAFYALSNIVRHNKDASALFVDNGGLEIMAPVLKHQNTGEKMKIRALALLTSVLTSLSADEKFSDRIREDKILEASLEHLAPSANPYLIDRVLNLLVLMKGSGAKFDTDELSKIRKSFASLYPVKDQLNEDDYNAVKEMLG
What is the function of this protein?
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP.  Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
What are the official names of this protein?
Hsp70 nucleotide exchange factor FES1.
What is the protein family that this protein belongs to?
Belongs to the FES1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_STAAE
Sequence: MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNADKQILERYKIGLKKG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 389L_IIV6
Sequence: MDLKDEFIQIIKKYSELSLKESENETKKYIQEVFNVSLSEVFIKEPSKQETLKQEPTQETNGCIYIFKKGKNIGQKCGSGKSKFCYKHKKNDLNIKVNQERNIKKPIPKPIPTNKIETGSVINQNWFIGTSIGKGGFGEIYSAAKFNDHGNYKDDDFSFAIKIEPKSNGPLFVEMHFYKRVIVEKEIEKFKLQKNIQYLGLPKYYGSGLYNDYRYIVMEKYDSNIDKLFRNGDLNSSTILQIGIQILNIVEYIHSKGYIHADIKGENILLKENDTSHIYLVDFGLCSRYSNIYQPDPKKAHNGTLKYTSRDSHQGVESRRGDLEILGYNMIEWSGGILPWQHLCKKSAGKKILNEVSESKIKYMNDLSLFFNKVQFNDTNLKNKLQTYFETIIKITFEELPPYQLLHNIFN
What are the official names of this protein?
Probable serine/threonine-protein kinase 389L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: BIOH_ECO8A
Sequence: MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPVEFCHLLVALKQRV
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDGC_PSEFS
Sequence: MWFKNLLIYRLTQDLPVDAEALEAAMATKLARPCASQELTTYGFVAPFGKGEDAPLVHVSGDFLLIAARKEERILPGSVVRDALKEKVEEIEAEQMRKVYKKERDQIKDEIIQAFLPRAFIRRSSTFAAIAPKQGLILVNSASPKRAEDLLSTLREVIGTLPVRPLTVKTAPTAIMTDWVTTQKPADDFFVLDECELRDTHEDGGIVRCKRQDLTSEEIQLHLTTGKVVTQLSLAWQDKLSFMLDDKMTVKRLKFEDLLQDQAEQDGGEEALGQLDASFTLMMLTFGDFLPALVEALGGEETPQGI
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL29_PROMA
Sequence: MAESEKLDVSKLTDIEIKEKIDVTRRELFDLRFQRATRQLNETHRFKKARVQLAQLLTAQGERSRSNT
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PROP_STAAN
Sequence: MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFLVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKN
What is the function of this protein?
May be a proton symporter involved in the uptake of osmolytes such as proline and glycine betaine.
What are the official names of this protein?
Putative proline/betaine transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSD_ECODH
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.