PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_LISIN
Sequence: MNPEQFQMALAEKGIELSDDQMKQFHDYFKMLVEWNEKMNLTAITDEKEVYLKHFYDSISAAFYVDFTKFDTICDVGAGAGFPSLPIKICFPHLKVSIVDSLKKRMTFLDALAEKLGLTDVHFYHDRAETFGQNKAHREKYDLVTARAVARMSVLSELCMPLVKKGGSFLVMKAAQAEQELQTAEKAIKLFGGKVEEHFAFALPVEESERNIYVITKTKETPNKYPRKPGTPNKLPIE
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFCN_ECO81
Sequence: MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKISEVPVKRLIQEQADASHYFSDEFQPLLNTEGPVKYVRPDVSHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: RL15_RAT
Sequence: MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_STRU0
Sequence: MRFEPFLNQEEIRQLQEFEKNGSKAQKRTPEQIEAIYTNGQNILVSASAGSGKTFVMVERIIDKVLRGISIENMFISTFTVKAANELKERLEKKLREGILMTDDPEMKAYLNDQMQAIALADIGTMDAFTQKLLNEHGYLLGIPPKFRIMQDKSEQELLKNEIYKSLFENYMASDHSQVFLRLVKNFSGNRKDSKSFRDQVYKIYQFSQSTENPKQWLENNFLLAANQYQDYDDLPDETIDALLQSMKETAISLRDLTDLEEYGQMTKAGKPTAKYVKHLTMIEALNDWSMHFDSYYGKSQIGKLAQDLSALLPSGTDVTVAGQKYPIFKDIQSKISQFRHLATLLTYQPETLPLLLELQSFVIDFTEAYLEAKKSENAFEFTDITHFAIEILQNEEAIRKVYQSKYHEVMVDEYQDNNHMQECLLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNQKFKDYQENPENGKLILLKENFRSQSEVIDATNAVFSHLMDEAVGDILYDDNHYLKAGSDKQKIRYPENNCQVLIYDTDQKDNGEDEHDKEDERRTEGQETLSPGEVNILVKEIIRLHQEEAVPFSDITLLVSSRTRNDLLFKTFNQYDIPLVSDGGQENYLKSVEVMVMLDTLRSINNPLNDYALVALMRSPMFAFNEDQLARIALQDSQEGKVEHFYEKVLNSLSHQGQHAELITQELHDQLELFDQSLNAWRDYSRTHSLYELIWKIYNDRFYFDFVGLSPKAEQAQANLYALALRANQFEKTTFKGLTRFISMIDNILNTENDLADVDLAKPKEAVNVMTIHKSKGLEFKYVFILNCDKKFSMADIHSPLILSRQKGVGIKFLADVKKELNATQLPSVKLYLETLPYQINKKELKIATLSEQMRLLYVAMTRAEKKLYLIGKGSQEKLSQKFDTKREGQHLPKALRESITNFQDWLLAIHQVFDSKDLSFTIDFVTDNELGPESIGSISHQSNIMIDDLRDNRQSDSIARAIDMLNNVNQLNQKYEAAINLPTVRTPSQLKKFYQPIMDIDGVEILADKSQTPTTFELPQFSKAKQVTSSQVGSALHELMQRIKITSHVTEKDIQQASQLVDAEAEVMAKIDLHKVKSFFEATELGRLIQVHHDKLYREAPFAMLKTDPQSQEKFVIRGIVDGFLLLEDKIILFDYKTDHYKTPLEMKLKYQEQMALYAESLRKAYDISTIESYLILMGKERIEIVECS
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: MTNN_ACTP7
Sequence: MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVGTALLLELTKPDVIINTGSAGGLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAAFLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKIAQIRQDFPNVAAVEMEAAAIAQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: AADH2_SOLLC
Sequence: MAIPNIRIPCRQLFIDGEWREPLKKNRLPIINPANEEIIGYIPAATEEDVDMAVKAARSALRRDDWGSTTGAQRAKYLRAIAAKVLEKKPELATLETIDNGKPWFEAASDIDDVVACFEYYADLAEALDSKKQTEVKLHLDSFKTHVLREPLGVVGLITPWNYPLLMTTWKVAPALAAGCAAILKPSELASITSLELGEICREVGLPPGALSILTGLGHEAGSPLVSHPDVDKIAFTGSGPTGVKIMTAAAQLVKPVTLELGGKSPIVVFDDIHNLDTAVEWTLFGCFWTNGQICSATSRLIIQETIAPQFLARLLEWTKNIKISDPLEEDCKLGPVISRGQYEKILKFISTAKDEGATILYGGDRPEHLKKGYYIQPTIITDVDTSMEIWKEEVFGPVLCVKTFKIEEEAIELANDTKFGLGAAILSKDLERCERFTKAFQSGIVWINCSQPCFWQPPWGGKKRSGFGRELGEWSLENYLNIKQVTQYVTPDEPWAFYKSPSKL
What is the function of this protein?
Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:23408433).  Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable).  Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (PubMed:23408433).  Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively (PubMed:23408433).
What are the official names of this protein?
Aminoaldehyde dehydrogenase 2, SlAMADH2, 4-trimethylammoniobutyraldehyde dehydrogenase AMADH2, Aminobutyraldehyde dehydrogenase AMADH2, Gamma-guanidinobutyraldehyde dehydrogenase AMADH2.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CITG_ECOLU
Sequence: MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQSLTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI
What is the function of this protein?
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
What are the official names of this protein?
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: TPIS1_RHIEC
Sequence: MTPDVRPLVAGNWKMNGTRASLDQIKAIAEGVRPPLADKVEALICPPTTLLYVATALCTDSPLAIGAQDCHQKPSGAHTGDISAEMIADSFGTYVIVGHSERRTDHAETDHLVRAKAEAAFAAELTAIICIGETADERRAGQELDVIKRQLSASVPDAATAENTVIAYEPIWAIGTGVTPTSGDVEKAHAFMRAELVSRFGDEGRKMRLLYGGSVKPANAGELLGIANVDGALIGGASLKAADFLAIYRAYEALLA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COA3_ZYGRC
Sequence: MVLDPSRYQDHRTWKMTPGLIRARQPFFKKNMIGLAILAGVSAGIYTYTYSFLHKDNDFADVPIPPIDEKELEKLKKEYEQHKQERQ
What is the function of this protein?
Required for assembly of cytochrome c oxidase (complex IV).
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SPRT_PSEE4
Sequence: MPELLKQRVETCYQQAETFFKRPFPRPQVSFKLRGQKAGVAHLHENLLRFNLQLYRENQDDFLRQTVAHEVAHLVAHQLFGDKIQAHGEEWQLIMRGVYELPPNRCHNYEVQRRVATRYIYRCPCPESDFPFTAQRHKLVRQGRRYLCRRCREILVYSGETRVE
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NBP35_PHANO
Sequence: MAPSLEEPTQIDFNAPLKAAPKLVAPEPEHCPGPESQQAGTADNCAGCPNQAICASAPKGPDPDIPLITARLSSVKHKILVLSGKGGVGKSTFSTMLSHGFSANPDSTVGLMDTDICGPSIPKMMGVEEETIHTTADGWEPVWVSENLGVMSVQFMLPNRDDAVIWRGPKKNGLIKKFLMDVKWGELDFLIVDTPPGTSDEHLSVNSFLKASGVDGAVLVTTPQEVALLDVRKEIDFCRKASIPILGIVENMSGFVCPGCKHESQIFRASTGGARKLAKEENIPFLGAVPLDPRIGMACDYGESFLTAYPDSPACAAIRDVVRRVGVEMGLEADEVLPEE
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NBP35, Nucleotide-binding protein 35.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_BACLD
Sequence: MNFETVIGLEVHVELKTKSKIFSSSPTPFGAAANTQTSVIDLGYPGVLPVLNKEAVNFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGENGWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDYNRQGTPLVEIVSEPDIRTPEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSFAFVQKGLEHEEKRQAQVLLSGGVIQQETRRYDEASKTTILMRVKEGSDDYRYFPEPDLVELYIDDEWKQRVKDSIPELPDERRKRYIEELGLPAYDAKVLTLTKEMSDFFEAAVEKGADAKLASNWLMGEVSAYLNAQQKELADVELTPEGLAGLVKLIEKGTISSKIAKKVFKELIEKGGDAEKIVKEKGLVQISDEATLRKLVTEALDNNPQSIEDFKNGKDRAIGFLVGQIMKASKGQANPPMVNKLLLEEINKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RL30_YERP3
Sequence: MAKTIKVTQTKSSIGRLPKHKATLIGLGLRRIGHTVEREDTPAVRGMVNLVSYMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: AMIA_SALTY
Sequence: MSTFKLLKTLTSRRQVLKTGLAALTLSGMSHAVAKEETLKTSNGHSKPKTKKTGSKRLVMLDPGHGGIDTGAIGRNGSQEKHVVLAIAKNVRAILRNHGIDARLTRTGDTFIPLYDRVEIAHKHGADLFMSIHADGFTNPKAAGASVFALSNRGASSAMAKYLSERENRADEVAGKKATDRDHLLQQVLFDLVQTDTIKNSLTLGSHILKKIKPIHKLHSRTTEQAAFVVLKSPSIPSVLVETSFITNPEEERLLGTTAFRQKIATAIANGIISYFHWFDNQKAHTKKR
What is the function of this protein?
Cell-wall hydrolase involved in septum cleavage during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase AmiA.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL16_BORBR
Sequence: MLQPSRRKYRKEQKGRNTGLASRGTHVSFGEFGLKATGRGRLTARQIEAARRAINRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYWVAEIQPGKVLYEMEGVSEELAREAFRLAAAKLPISTTFVARHIGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ULK3_CHICK
Sequence: MAGGGCAPPRLDGFVLTERLGTGTYATVYKAYGKRDTREVVAVKCVSKRSLNRASVENLLTEIEILKTIRHPHIVELKDFQWDSDHIYLIMEFCAGGDLSRFIRMRRILPEKVARIFLQQLACALKFLHDHNISHLDLKPQNILLSTPENPQLKLADFGFAQYMSPWDEKHVLRGSPLYMAPEMVCRQQYDARVDLWSVGVILYEALFGRPPFASRSFAELEEKIRSDRAIELPSRPPLSPDCRDLLQRLLERDPLKRISFEEFFAHPFVDMEHMPGPESFCKATNLVVEAVKKDQEGDASAALSLYCKALEYFVPALHYESDARRKEAIRTKVGQYISRAEELKALVASKSKNLLQQGNPAREILKEMAKDKPRLCAALEMASVAVAREEEGKDDGDTLELYQQSLGELLLLLAAEPAGRRRELLHAEIQTLMARAEYLKDQIKMREAQSMGKEALADSVRSSCTLQ
What is the function of this protein?
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.
What are the official names of this protein?
Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD417_YEAST
Sequence: MLPLCLTFLSFFLSLGGSFKAVMTKEEADGTTEAAACLFWIFNWTVTLIPLNSLVALAISSPTFFGDKPNGPIFGAKAAEAPTSPPTALKYKYLTSFGSNFGGILTIDLSFYWALGVALTGSK
What are the official names of this protein?
Putative uncharacterized protein YDR417C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YTJA_SALSV
Sequence: MFRWGIIFLVIALIAAALGFGGLAGTAAGAAKIVFVVGIVLFLVSLFMGRKRP
What are the official names of this protein?
UPF0391 membrane protein YtjA.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MYG_MOUSE
Sequence: MGLSDGEWQLVLNVWGKVEADLAGHGQEVLIGLFKTHPETLDKFDKFKNLKSEEDMKGSEDLKKHGCTVLTALGTILKKKGQHAAEIQPLAQSHATKHKIPVKYLEFISEIIIEVLKKRHSGDFGADAQGAMSKALELFRNDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: Y2651_BACCN
Sequence: MASETVTNHQEKALALLQADAEKILRLIKVQMDHLTMPQCPLYEEVLDTQMFGLSREVDFAVRLDLISEEQGKEMLGELERELSALHEAFTNKK
What are the official names of this protein?
UPF0358 protein Bcer98_2651.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: NARFL_XENTR
Sequence: MASSFSGVLQLTDLDDFIGPSQECIKPIKVEKKAGRAAAKIQIEDDGSYVQINPEGAARKLEKAKITLNDCLACSGCVTSAETILITQQSHEELYKILKQNKTENPLEHKVVVVSVSPQSWASLAARFNLIMQDTAQKLTAFFKQLGVHHVFDTNFSRNFSLLESQREFIQRFKRQKEDKKSLPMLASACPGWICYAEKTHGSFILPYISSTKSPQQVMGSLVKSHFAKEKNLKPNQIYHVTVMPCYDKKLEASRPDFYNQEYETREVDCVITTGEVLRMLEQEGLSLSDVDPSPLDTLFGSAVQEEPVGHQGGGSGGYLEHVFRHAAQELFGVHVDTVVYKPLKNKDFQEVTLEQDGNVVLHFALAYGFRNIQNLVQKLKRGRCPYHYVEVMACPSGCLNGGGQIKAEGEGSKDLLQRVEDLYNTVRTERPEEREEVAQLYGDWLEDKDSAKARQALHTQYHAVEKINSGLTIKW
What is the function of this protein?
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor narfl, Nuclear prelamin A recognition factor-like protein.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: MIAA_ANAPZ
Sequence: MEKEIVVVTGPTASGKSAACDIIADDLNCRVINCDSKQIYHGVPILTDQPVSVRDIHKLYGYVAPTQNYSAGLWLQDVKREVQQAWDDNVLPVITGGSGMYINSLVNGISDIPAIDPEVRKTARNLLESLGNAAFYEALVARDSNAARLHHNNTHQILRAFEVLEQTGTSIFTWWERSPRIKPFENCEVLVLLPPRNKLYDKINRRFLTMMQTDAISEVKYLMSLNLPMHAPVMKAHGAPEIVQYLQGKIEFMEAVEIAQKNTRHYAKRQCTWFRTQLPCDTRFFSSQNEIIDHVLAQYASKYPRTHTRPCN
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RIMO_METPP
Sequence: MTQTADAASTALTSGDAASRNIPKIGFVSLGCPKALTDSELILTQLRAEGYDTSKSFAGADLVIVNTCGFIDDAVKESLDTIGEALAENGRVIVTGCLGAKAGEGGGNLVRQMHPSVLAVTGPHATQEVMDAVHVHVPKPHDPFVDLVPAYGVKLTPRHYAYLKISEGCNHRCSFCIIPSMRGDLVSRPIGDVLNEARALFESGVKELLVISQDTSAYGVDVKYRTGFWDGKPVKTRMTDLVERLGELAEPFGAWVRLHYVYPYPHVDEILPMMAGGRVLPYLDVPFQHAHPDVLKRMKRPANGEKNLERLQRWREACPQIVVRSTFIAGFPGETEAEFEHLLDFMREARIDRAGCFAYSPVEGASANALAGALPEAVREERRARFMAVAEAVSAEKLRERVGAEMQVLIDAAPALGKKGGRGRSYADAPEIDGVVHLLPPQKASKQLRVGEFTRARIVGTQGHDLVGQPL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTP_ROSDO
Sequence: MRLFTKIKGLAAVTCVAALASSAAFAQEMTLKLGHLANEQNAWHLAAVKFGEELSTLTDGRIAVEVFPNESLGKEIDLINGMQLGTVDMTITGESLQNWAPMAALLAVPYAYKSLEHMDEVASGEIGEQIKQQIIEKAQVRPIAFFARGPRNLTSQRPITSPADLDGMKMRVPNVPLFVDVWSALGASPTPMAFSEVFTSLQNGVIDGQENPLALIRSANFNEVQGYVNQTEHVRSWIYLTIAESTWAKLSEDDQNAVMQAAATAQEYERGLLLESLAEDRGYLESKGMTFVEVDGAAFQAAAKDAVLANVSEEIRPIVESLFSE
What is the function of this protein?
Solute-binding protein that binds L-galactonate and D-mannonate (in vitro) (PubMed:25540822).  Probably part of a tripartite ATP-independent periplasmic (TRAP) transport system that mediates solute transport into the cytoplasm.
What are the official names of this protein?
Solute-binding protein RD1_1052.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VCP_VACCC
Sequence: MKVESVTFLTLLGIGCVLSCCTIPSRPINMKFKNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYHLIGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWKPELPKCVR
What is the function of this protein?
Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation.  Binds C3b and C4b.
What are the official names of this protein?
Complement control protein C3, 28 kDa protein, Secretory protein 35, Protein C3, VCP.
What is the protein family that this protein belongs to?
Belongs to the receptors of complement activation (RCA) family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Anchored to the surface of the outermost membrane of EEV via its interaction with A56 protein (By similarity).
Protein: ARP2_ASPFU
Sequence: MVNTCTYLPLSGKVALVTGGGRGIGAGIALELARRGASVAINYGHSAKSAQEVVEAIQAIGRQAVAIQADLTCVPNIESLIQEVVRHFGRLDIVVSNSGMEKFKPLEETTLEDFNEVFNLNTRAQMFVARYAYDHIQPGGRVILMSSIAAGLGVPGHALYAGSKAAIEGFTRCLAADFGRKGCTVNAIAPAGVKSDMWRENAWRYAPGCDKSSSLEEIETALASGSPLKRCGVPEDIGKVVSFLASPDAEWVNGEFFSPPPCKGPLPGGDLEC
What is the function of this protein?
Hydroxynaphthalene reductase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:10515939, PubMed:19156203).  The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA (PubMed:10515939).  The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening (PubMed:10515939).  1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone (PubMed:10515939).  The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN (PubMed:10515939).  1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone (PubMed:10515939).  Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN (PubMed:10515939).  Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin (PubMed:10515939).  DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize (PubMed:26972005).  DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins (PubMed:19703288).  DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses (PubMed:19156203, PubMed:20145078, PubMed:21747802, PubMed:21573171, PubMed:24818666).  DHN-melanin protects also conidia against amoeba predation (PubMed:25684622).
What are the official names of this protein?
Hydroxynaphthalene reductase arp2, Conidial pigment biosynthesis oxidase arp2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endosome.
Protein: CDC23_YEAST
Sequence: MNDDSQDKIIHDIRIQLRKAATELSRWKLYGSSKWAAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKQMFEIPQNGFGLSETEYDLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGKFTDEMYRANKDGDGSGNEDINQSGHQRANLKMVSNEHESQSNISSILKEINTFLESYEIKIDDDEADLGLALLYYLRGVILKQEKNISKAMSSFLKSLSCYSFNWSCWLELMDCLQKVDDALLLNNYLYQNFQFKFSENLGSQRTIEFNIMIKFFKLKVFEELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQDPYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEELLEGIVTDETVKARLWLAIFEIKAGNYQLAYDYAMGVSSGTSQEIEEARMLARECRRHM
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition.  In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
What are the official names of this protein?
Anaphase-promoting complex subunit CDC23, Cell division control protein 23.
What is the protein family that this protein belongs to?
Belongs to the APC8/CDC23 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Protein: PG058_VACCW
Sequence: MKHRLYSEGLSISNDLNSIIGQQSTMDTDIEIDEDDIMELLNILTELGCDVDFDENFSDIADDILESLIEQDV
What are the official names of this protein?
Protein OPG058, Protein F14.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG058 family.