PharMolix/UniProtQA huggingface dataset:
Protein: SBT4F_ARATH
Sequence: MVSNQRVRLFMLCFCLVNNAVIAATEDENVERKPYIVYMGEATENSLVEAAENHHNLLMTVIGDESKARELKIYSYGKNINGFVARLFPHEAEKLSREEGVVSVFKNTQRQLHTTRSWDFLGLVESKYKRSVGIESNIIVGVLDTGIDVESPSFNDKGVGPPPAKWKGKCVTGNNFTRCNNKVIGAKYFHIQSEGLPDGEGDTAADHDGHGTHTSSTIAGVSVSSASLFGIANGTARGGVPSARIAAYKVCWDSGCTDMDMLAAFDEAISDGVDIISISIGGASLPFFEDPIAIGAFHAMKRGILTTCSAGNNGPGLFTVSNLAPWVMTVAANSLDRKFETVVKLGNGLTASGISLNGFNPRKKMYPLTSGSLASNLSAGGYGEPSTCEPGTLGEDKVMGKVVYCEAGREEGGNGGQGQDHVVRSLKGAGVIVQLLEPTDMATSTLIAGSYVFFEDGTKITEYINSTKNPQAVIFKTKTTKMLAPSISSFSARGPQRISPNILKPDISAPGLNILAAYSKLASVTGYPDDNRRTLFSIMSGTSMACPHAAAAAAYVKSFHPDWSPAAIKSALMTTATPMRIKGNEAELSYGSGQINPRRAIHPGLVYDITEDAYLRFLCKEGYNSTSIGLLTGDNSNNTTKKEYNCENIKRGLGSDGLNYPSLHKQVNSTEAKVSEVFYRTVTNVGYGPSTYVARVWAPKGLRVEVVPKVMSFERPKEKRNFKVVIDGVWDETMKGIVSASVEWDDSRGHLVRSPILLFRSDNDYR
What are the official names of this protein?
Subtilisin-like protease SBT4.15, Subtilase subfamily 4 member 15, AtSBT4.15.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NTA_SELEF
Sequence: DCLGWMAGCDFNDNKCCAGYVCKKHPWCRYDL
What is the function of this protein?
Voltage-gated sodium channel Nav1. 7/SCN9A inhibitor.
What are the official names of this protein?
Mu-theraphotoxin-Se1a, Mu-TRTX-Se1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF3_PSET1
Sequence: MAEQNLLSEINKRRTFAIISHPDAGKTTITEKVLLFGQAIQKAGTVKGRGSNQHAKSDWMDMEKERGISVTTSVMQFPYKNALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRTTPIVTFMNKCDRDIRDPMELLDEVETELKIACAPITWPIGSGKGFKGVYHIHNDEAVLYKTGQGHKIQDVRTIKGIDNPELVDAIGDDLAAQLRDELELVIGASNEFDLELFLAGELSPVYFGTALGNFGVDHVLDGLTKWAPTPLPRETEDRQVVATEENFTGFVFKIQANMDPKHRDRIAFMRIVSGKYSQGMKMNHVRIGKQVSISDAVTFMAGDRERAGDAFAGDIIGLHNHGTIQIGDTFTQGEKLKFSGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLINNDLIVGAVGVLQFDVVVARLKAEYNVDAIYEGVNVNTARWVSSDDVKKFEDFKRKCESNLALDGGDNLTYIAPSRVNLNLSVERYPEVTFSHTREN
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSOSC_HALNC
Sequence: MAAVTGIALGMIETRGLVPAIEAADAMTKAAEVRLVGRQFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARVHSEVENILPKAPEA
What is the function of this protein?
Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein.  CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb.  The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices.  CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.
What are the official names of this protein?
Carboxysome shell protein CsoS1C.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Protein: ANMK_ECOL5
Sequence: MKSGRFIGVMSGTSLDGVDVVLATIDEHRVAQLASLSWPIPVSLKQAVLDICQGQQLTLSQFGQLDTQLGRLFADAVNALLKEQNLQARDIVAIGCHGQTVWHEPTGVAPHTLQIGDNNQIVARTGITVVGDFRRRDIALGGQGAPLVPAFHHALLAHPTERRMVLNIGGIANLSLLITGQPVGGYDTGPGNMLMDAWIWRQAGKPYDKDAEWARAGKVILPLLQNMLCDPYFSQPAPKSTGREYFNYGWLERHLRHFPGGDPRDVQATLAELTAVTISEQVLLSGGCERLMVCGGGSRNPLLMARLAALLPGTEVTTTDAVGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGASQETVLGAIFPANP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RS20_THIDA
Sequence: MANSAQARKRARQASAQRDHNMSQRSELRTAIKKVRKAIEAGDKAAAQAVYQSSVSVIDSIADKQIIHKNKAARHKSRLSLAVKGMA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL15_ALTMD
Sequence: MRLNTISPAEGSKPTGKRSGRGIGSGLGKTGGVGHKGQKSRSGGRVKPGFEGGQMPIQRRLPKFGFTSRKSFVTDQVTLAEIAKVDGDTASLETLKAAGLVKKEIQFVKVVKSGEVSRAVTVSGLKVTKGAKEAIEAAGGKVEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL23_BIFA0
Sequence: MVAIHKPAHDIILKPVVSEKSYALSDMGQYTFVVAPNANKVQIKQAIEEIFKVKVTNVNTLNRAGKRTRTRTGYGRRVNQKRAIVTVAEGQSIDIFGN
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: YIAA_SHIFL
Sequence: MDNKISTYSPAFSIVSWIALVGGIVTYLLGLWNAEMQLNEKGYYFAVLVLGLFSAASYQKTVRDKYEGIPTTSIYYMTCLTVFIISVALLMVGLWNATLLLSEKGFYGLAFFLSLFGAVAVQKNIRDAGINPPKETQVTQEEYSE
What are the official names of this protein?
Inner membrane protein YiaA.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIBF_GEOTN
Sequence: MKVHEANQGLTLPGSVVAIGAFDGVHQGHQAVLRQAVERSRQLGVESVAYTIDPPPRCRFQGSRMLTTLQEKLDRFAVLGLNHAVVAHFDERYAARRVDAFIRELTALNPREVIVGQDFRFGRNREGDVALLRRHFPVRIVQTVCCADGQRISSTRIRELIERGEWEQSTVLLGWPLSS
What is the function of this protein?
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
What are the official names of this protein?
Putative bifunctional riboflavin kinase/FMN adenylyltransferase, Putative riboflavin biosynthesis protein RibF.
What is the protein family that this protein belongs to?
Belongs to the RibF family.
Protein: TRM10_THEKO
Sequence: MKTLADVFREALKEKGISSIGTLSKRFRKSKNKLQDIAIEIVHGKGAVFRVPEKTAVAWDLNGNRVDGSYYAYAPLCMREKFEPVLTPEELREKLPDWPYFIIDLYHWDKHTQKEKGKICLQVNQSYGLLRDYFTGSELAVTWANEEFREMFHGPLDRITTYGGPTSEFLKENGINEVVLLDPWAEEVLSEKDFDVKAFIIGGIVDTGGNKKKTTPKIGEELESAGIKVRRRKIVLRGDVVGVPDRINRILGIILKMMVEGKSMDEAVYEMQEPLHARWRLRKELPKRATRYMVEGKVYRVVEKELFDEYSKWLKIRWEDFVKVLRELDLVALERKRIHHLNKISNARIINGKLHRVILLKRAAMLCYNC
What is the function of this protein?
Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA.
What are the official names of this protein?
tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_BACSU
Sequence: MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase, General stress protein 38, GSP38, Spore outgrowth factor B, Sporulation protein OutB.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: ECI1_RAT
Sequence: MALAAARRVLLQAGSRLGRRGAVDGARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLEKLKQKKG
What is the function of this protein?
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
What are the official names of this protein?
Enoyl-CoA delta isomerase 1, mitochondrial, MECI, 3,2-trans-enoyl-CoA isomerase, Delta(3),Delta(2)-enoyl-CoA isomerase, D3,D2-enoyl-CoA isomerase, Dodecenoyl-CoA isomerase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CRCB_BURCH
Sequence: MFYSIVAIFVGAGLGALLRWFLSLALNAFFPAVPLGTLASNLIGGYVIGVAAVVFTVRVGLPPEWRLFVITGFLGGLTTFSTYSVEVMTHALEGEFGWALAVAALHLTGSFALTALGMWTARAWLAAA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EI3F2_DROVI
Sequence: MSISNYKLQTKVRLQPLVLFQIIAAYERRPKTAKMAVGTLLGRRDRCNDIIEITNSYTVQHKEQQIGEMEQFKLDTQYASEMFELNQITYPQEKIIGWYSTGKSLSRSAAALHAYYSRECGDVQPLHLLVDTTLRGGHLSTRLYCGVTMGVPGGTRGLLFTLLPLLKLNTDGDESVALRLMQKQALHPTKQLGRMLPELVHVMEATRELEQKLELVMRYINDVLARKRRPDNSIGRALHDALTSVPLLDAESFRLMFNANVRNMLMSITLSTMIKTQMELSEKLSYLPDH
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F-2, eIF3f-2, Eukaryotic translation initiation factor 3 subunit 5-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESA1_DEBHA
Sequence: MSVGEDKSGTATPQHNTSIRITDDEERSDEKKFTDDDIITGCKLYVSKDGEYRLAEILQDHMKKGKKVFYVHYQEFNKRLDEWISADRIDFTRALISPQVKVDKKDDKKEGKSKTSKKSKSKNGKTGSKSVTSTPQPNEDTAPGTPRNDDEMDLDNLNVQGLKRPGEEVSREDEIKKLRTSGSMTQNHSEVARVRNLSSVILGEHIIEPWYFSPYPIELTEEDEIYICDFTLAYFGSLKQFERFRTKCSMKHPPGNEIYRDSKVSFWEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYIMTVKSSQGHHVVGYFSKEKESADGYNVACILTLPCYQKMGFGKLLIQFSYMLSNVENKVGSPEKPLSDLGLLSYRAFWTDTLVKLLVERNNPHLFKKNNPQLLTEASSKDSSVSPPPGGRQSANIQNGNTPSSDITIDEISSITCMTTTDILHTLTALQILRYYKGQHIIVITDHVMAMYDKLVKKIKDKKKHELDPSKLSWTPPAFTANQLRFGW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: FRDD_HAEDU
Sequence: MNKQDPKRSNEPPVWLMFSAGGTISAICFPVLILILGILLPLGLIPMDNIIVFAHTWLGKLVILAVTIFPMWAGMHRVHHGLHDLKIHLPASGWLFYGLSTLYSIVVLFAVIAL
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOC_AYWBP
Sequence: MSDNRLFTSVETLNLSSPVLEKLKLSGINTLEDFNTFTLEELRLLLQEAFLEVLPILKNFALPRNLQNLDLSEAVINILTELGMEDFQDLLQTKMAVLTKSFETNPLAFQKLNDLFKLYNHFPSISSDKEYGSRDYDYFKIRLAAPEEIRQWSYGEVTSYETINYRTYKPEISGLFCQKIFGPVVDFQCACSKKQVSIKSQFCNKCGVEFTETKVRRERMGHIELQTPIVHTWYLNSSPSRLAILLNIKTKQLEEIVYYVSYVVIDPGKTEFKPKEIITETQYSEALYEFGNTFVALTGAEAVKKLLENLNLEKTIKVLRKSLSENSKQKRESIIKRLEIIESFHQSDNKPEWMVMDVIPVLPPGLRPMVPLDGGRFATTEVNDLYRRILNRNNRLKKQMLQKAPRLIIKNEKRMLQEAVDALFDNTKTSKKNVNNVEKNRPLKSLSEMLRGKQGRFRQNLLGKRVDYSGRSVIIVGPDLEMHQCGVPREMAIILFKPFILKKLQETKGIDKKNANTIYEKMNEEVWNALEEVVKEHPVLLNRAPTLHRLGIQAFDPKLIDGKAIRLHPLVTPAFNADFDGDQMAIYVPLSLEAQAEARLLMLVSNNILDPKNGNPVVTPSQDMVLGNYYLTIEEKKDRTINSYDSAQRTAEHQFKHRNEGTFFADINEAKTAYQNKEIHLHTRIFIKPQTINLSFTEEQRQKYLMTTLGKLIFNDILPPSFPYINEPTQFNLDVKTPDAYFLPPGTNPKQFLKKLPTPKPFNKKFLSMIIACFFKQMKITETSKMLDHIKNLGFKYSTIAGITVSFADINTYSNKQELLQEVETRNIQIETWHKDGFLTDAERRRLVINEWKTIRDEIQEGLMKEFKQDNHIFMMSESGARGSVSNFTQLAGMRGLMNNPKGEIIEVPVKASFREGLKVSEFFISTHGARKGSTDTALKTAESGYLTRRLVDVTQDIVVIKEDCNSDRGFIVEAMMSDGKEIVSLKKRIMGRFASCDICHPKTNTLIVARNELIIESKAQEIITAKIKKVPIRSILTCNCEYGICAKDYGVNLATNKLVEIGEAVGVIAAQSIGEPGTQLTMRTFHTGGVASASDITQGLPRIEELFEVRKPKGKALISELKGKIKKIDKIRSQNPEIVITEENDPDTEHRYILEPNVDILVSKNNIVYPGQKLTSGSVDLKELLRVAGTTEVQKYILEEVQKVYRAQNVYISDKHIEIIIHQMFKQILIIDEGDTHLLPGTEITINKFKKANLKMLEEKKRLAVGRPIILGITRSSLRSDSLLSAASFQETTKILIDAAIKGKTDHLYGLKENVIIGGLIPAGTGILETTLFKYPKEPATTSELTKKTNQN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: NUOE_AQUAE
Sequence: MFKTEFEFPEELKTKLQEHINYFPKKRQAILLCLHEIQNYYGYIPPESLKPLADMLELPLNHVEGVVAFYDMFDREDKAKYRIRVCVSIVCHLMGTNKLLKALENILGIKPGEVTPDGKFKIVPVQCLGACSEAPVFMVNDDEYKFESEVQLNEILSRYT
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit E, NADH dehydrogenase I subunit E, NDH-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the complex I 24 kDa subunit family.
Protein: TIG_ERWT9
Sequence: MQVSVETTQGLGRRVTITVDKDVIENAVKSELVSVAKKVRIDGFRKGKVPMTVVAQRYGASVRQDVLGDLMQRNFVDAIIKEKINPAGSPQYVPGEYKIGEDFTFSAEFEVYPEVELQGLDAIEVEKPVVEVTEADVDTMLETLRKQQATWKETDAAATAEDRATIDFSGSVDGEEFEGGKASDFVLAMGQGRMIPGFEEGVVGHKAGETFTIDVNFPEDYHAENLKGKAAKFDIVLKKVEERELPELTEEFIKRFGVEAGSLDGLRAEVRKNMQRELKGAVRNRVKTQAIDGLVKANDIDVPAALVDGEIDVLKRQAAQRFGGDEKQALELPRELFEEQAKRRVVVGLLLGEVIRTHELKADETRVNALIEEMASAYEDPSEVIEFYSKNNELMNNMRNVALEEQAVEAVLEKAKVTEKATNFQELMNQTATA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RZOR_ECOLI
Sequence: MRKLKMMLCVMMLPLVVVGCTSKQSVSQCVKPPPPPAWIMQPPPDWQTPLNGIISPSGNDW
What is the function of this protein?
Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit.  The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity).
What are the official names of this protein?
Prophage outer membrane lipoprotein RzoR, o-spanin, Outer membrane lipoprotein Rz1 from lambdoid prophage Rac, Spanin from lambdoid prophage Rac, outer membrane subunit.
What is the protein family that this protein belongs to?
Belongs to the lambdalikevirus o-spanin family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: TREF_ECOSM
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKG6_BPPRD
Sequence: MDTEEIKEEMQEAAEAAIENAVETAELETAAIKAEGAAAAAEQSAEQAAVMAATLAASVEANAAQQIAEHSEQVQTQEEKISWLENQVMAMASNLQMMQEAVTALTVSQSLTPEPSPVPAVEVEAMPEAVTVEILPESAGDQQEAEPVPSVGDQQETAPRKRFRAI
What is the function of this protein?
Together with the packaging ATPase P9, forms the external part of the portal vertex that is embeded in the capsid and which plays critical roles in genome packaging and genome ejection.  Both proteins multimerize as a single ring-shaped heterdodecamer arranged around a central channel.
What are the official names of this protein?
Packaging efficiency factor P6.
What are the subcellular locations of this protein?
Virion. Note=Localizes at the unique vertex of the capsid, which extends to the internal membrane via two small integral membrane proteins, P20 and P22. Packaging efficiency factor P6 attaches to the virion via these proteins and is, in turn, necessary for the attachment of DNA packaging protein P9 to the capsid.
Protein: LPXC_PSESM
Sequence: MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDTTLSTTLVNGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLEEQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDFDHPVFRDRTQSASVDFSSTSFVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRALIEQTDAWEVVTFEDASTAPISYMRPVAAV
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: GRAR_STAAE
Sequence: MQILLVEDDNTLFQELKKELEQWDFNVAGIEDFGKVMDTFESFNPEIVILDVQLPKYDGFYWCRKMREVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFYTNVLIAKLQAIYRRVYEFTAEEKRTLTWQDAVVDLSKDSIQKGDQTIFLSKTEMIILEILITKKNQIVSRDTIITALWDDEAFVSDNTLTVNVNRLRKKLSEISMDSAIETKVGKGYMAHE
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Response regulator protein GraR, Glycopeptide resistance-associated protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCA_ECODH
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFTNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: PAN1_HALSA
Sequence: MTDTVEDVELPYDDSASQQDKLEALEEQLSTLEEENEEMRDRLLDANAENNKYQQKLERLSHENKKLKQSPLFIATVQELTDEGAVIKQHGNNQEALTEVTDELRATLEPGSRVAVNNSLSVVRQLDDEADVRARVMEVDDSPDVGYEDIGGLDDQLREVRETVELPMKDPGLFETVGINPPSGVLLHGPPGTGKTLMAKAVASQTDASFIKMAGSELVHKFIGEGAKLVRDLFQVARDHEPAVVFIDEIDAIASKRTDSKTSGDAEVQRTMMQLLSEMDGFDERGDIRIIAATNRFDMLDRAILRPGRFDRLIEVPHPNVGGREKIFRIHTRAMNVADSVDFGELAADTGDLSGADVKAICTEAGMFAIRDDRTEVRMQDFQSAREKLDQDSEPAAATDVSRTFA
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase 1, PAN 1, Proteasomal ATPase 1, Proteasome regulatory ATPase 1, Proteasome regulatory particle 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.