PharMolix/UniProtQA huggingface dataset:
Protein: LYST1_DICDI
Sequence: MVSSIKDMLKYDEGEKLEMYKDTEGYYTIGIGHLITRIKERNAAILSLEEKIGHKVKMDSKNEPIITSSESEALFEKDLSVATKSIESNPTLSTIYKNLDNIRKMAIINMVFQMGVNNVLTFKMSLKLIEEKKWAEAAKEMKNSTWNHQTPNRSNRVISVIETGTLNAYK
What are the official names of this protein?
Probable T4-type lysozyme 1, Muramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
Protein: RIBBA_RHOE4
Sequence: MTRFDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLDGDDCDRLGLPPMYATNQDKHGTAYTVTVDAREGIGTGISASDRAATMRLLANPESGANDFTRPGHVVPLRAKEGGVLRRPGHTEAAVDLARMADLRPAGVICEIVSQKDEGAMAQTDELRVFADEHNLALISIADLIAWRRKHEKHVLRIAEARIPTRHGEFTAVGYTSIYDEVEHVALVRGDIAGPDGDGSDVLVRVHSECLTGDVFGSLRCDCGPQLDAALDMVAQEGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGSDTVDANLELGLPADARDYGIGAQILVDLGISSMRLLTNNPAKRVGLDGYGLQITDRVPMPLRANAENLTYLRTKRDRMGHDLIGLDEYEANQNTAQPGTAL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: RUVB_OCEIH
Sequence: MDDRMIDGELQDQDVEIELSLRPSTLSQYIGQDKVKENLTIFIQAAKMREEPLDHVLLYGPPGLGKTTLASIISYEMGVQFRSTSGPAIERAGDLAAILSSLEPGDVLFIDEVHRLPRSVEEVLYAAMEDFFIDIVIGTGPSARSVRIDLPPFTLVGATTRAGLLSAPLRDRFGVLSRLEYYEIKDLCNIVERTADIFNMPISSEAAIEVARRSRGTPRIANRLLKRVRDISQVKGEEEISLESTKQALEMLQVDDAGLDHVDHKLLTGIIEGFSGGPVGLDTIAATIGEESQTIEEVYEPFLLQLGFIQRTPRGRVITSKAYDHLGIKRTGED
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CCZ1_XENTR
Sequence: MAYAVQDKRFAPSLLSFFIYNPKFGPREGEEEKKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFNPTKPAKSLHTQKNRQFFHEPEEGFWMVMVVKNPLAEKQKEGKTVLEYQEDELLDKVYSSVLQQCYRMYKLFNGTFSRAMEVGQVELLKDRLEKFFHRYLQTLHLHSCDLLDVFGGISFFPLDKMTYLKIQSFINRIEESLNIVKYTVFLYNDQLIWSGLEQEDMRILYKYLTTTLFPRYTEPELAGRDSPIRPEMPGNLQHYGRFLTGPLNLSDPEVKFRFPKIFVNTEDSYEELYLIVYKAMSASVCFMIDASVQLTVDFCRKLDSLVGPQLTVLASDICEQFNINRRISGSEKEPQFKFIYFNHMNLAEKSTIHLRKTPSMSLTSVQPELMKILGDINGDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNSNLIEVNEEIKKLCATQFSNIFFLD
What are the official names of this protein?
Vacuolar fusion protein CCZ1 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCZ1 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: AROC_STRMK
Sequence: MSSNSFGKLFTVTTFGESHGPAIGCVIDGCPPGLALDAAEFGHDLQRRATGKSRHTSARREADEVEILSGVYEGLTTGTPIALLIRNTDQRSKDYANIGQQFRPGHADYSYWHKYGIRDPRGGGRSSARETTMRVAAGVVAKKWLAERFGVTVRGYLSQLGDITPAGFDWSAVEDNPFFWPHAAQVPELEAYMDALRKSGDSVGARVDVVADNVPPGWGEPIYGKLDGELAAALMSINAVKGVEIGDGFASAAQKGTEHRDLLTPQGFASNHAGGILGGISTGQPVVASMVLKPTSSLRLPGPSLDTAGNVVEVVTTGRHDPCVGIRATPIAEAMVAMVLMDQALRHRAQCGDVGTITPRIPGQIDG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ARAA_ECOK1
Sequence: MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: QUEF_PSEA8
Sequence: MQHPAEHSPLGKTSEYVSSYTPSLLFPISRTAKWAELGLSAETLPYRGVDIWNCYELSWLTPAGKPVVAIGEFSIPADSPNIIESKSFKLYLNSLNQSAFDSREALRAVLQKDLSAAAGAPVGVRLRSLDEVAEEGIGRLPGRCIDELDIAVDGYEQPRPELLRCDAGRIVEEQLYSHLLKSNCPVTGQPDWGTLVVDYRGPALDPASLLAYLVSFRQHQDFHEQCVERIFLDLQRLLQPQALSVYARYVRRGGLDINPYRSLAEVAPDNRRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_RHIWR
Sequence: MRVDLFDFDLPPENIALRPASPRDSARMLLVEGSEGALADRHVSDLPGLLRVGDCLVFNDTRVIPAQLEGRRGEARIGATLHKREGLRQWRAFVRNAKRVRTGDRIDFGAGVSAIAAERGEDGSILLDFEGDEPVELLLERAGTMPLPPYIAGKRPTDDRDRDDYQTMFAREKGAVAAPTAALHFTPRLMEALAAAGIASETLTLHVGAGTFLPVKADDTDDHRMHAEWGRIDAATADHLNAIRAAGGRVIAVGTTSLRLLESATGEDGVIRPFDGDTAIFITPGYRFRAIDGLMTNFHLPKSTLFMLVSALMGRDRMQAAYAHAIAEGYRFYSYGDSSLLLPG
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JAP_RHIAP
Sequence: MKVLRCLVCSFYIIVSLITTMTIGTPSMPAINTQTLYLAGHSSKLFERNVGCVKTRYLNQTGDWVTRSLIYVFTFDTEPWVTQAGAFQVKWEPYSPLLRVKASDYVRDNLGAKPDYFIRTYDNDFLLLSDLKEVRSTCSLWVTLKYVDRIPETINRTFYTICPDPVPVPFDERCYP
What is the function of this protein?
Salivary tick protein that modulates host immune response.  This protein blocks dendritic cell (DC) differentiation from monocytes (PubMed:23825947).  In addition, it inhibits up-regulation of costimulatory molecules and pro-inflammatory cytokines in response to stimuli and promotes up-regulation of co-inhibitory molecules and the anti-inflammatory cytokine interleukin-10 (PubMed:23825947).  It has a pocket to accomodate cholesterol, which may have immune-modulatory roles, either directly or through interactions with the host gut microbiota (Probable).
What are the official names of this protein?
Japanin, 18 kDa immune-modulatory lipocalin, Cholesterol binding protein.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: GLGB_STRA5
Sequence: MSNKDELYTFGIGENFHLQNYLGVHSENGSFCFRVWAPNAENVQVIGDFTDWRNRPLQMNKNQAGVWEANSLDAREGDLYKYLVTRKGGQVVEKIDPMAVYMERRPGTASVIKVLRNKKWEDGLWMGRRKRLGFQKRPINIYEVHAGSWKKDDFGHPMTFSQLKDYLIPYLVEMNYTHVEFMPLMAHPLDMSWGYQLMGYFAFEHTYGTPEEFQDFVEACHKNNIGVLVDWVPGHFIQNDDALAYFDGTATYEYQNHDRAHNYRWGALNFDLGKNQVQSFLISSALFWIEHYHIDGIRVDAVSNMLYLDYDEGPWEANQFGDNRNLEGYHFLRKLNKVIKERHPNVMMIAEESTASTPITKDLESGGLGFDFKWNMGWMNDILRFYEEDPLYRQYDFNLVTFSFMYIFNENFVLAFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNLYAYQMCHPGKKLLFMGSEFGQFLEWKYNDQLEWENLNDDMNQKMQRYTKQLNQFYKDHKCLWRIDDSFDGLEIIDADNKSETVLSFIRKDDKGDLLLCVFNMTPVERPNFTIGVPQAGIYEEVLNTEMEEFGGVWKNHNPVTKTQVATWKDYDHTLSFTLPALGASVWRIKRRLRK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: TYPH_YERE8
Sequence: MFLAQEIIRKKRDGQALSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGPMVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDSAFRKIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYQLSEDLAKAIVGVANGAGCKTTALLTDMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAQNDADARAKLQAVLDNGKAAEIFGRMVAAQKGPSDFVERYDSYLPAAMLSKPVFAERSGIITAMDTRALGMAVVSLGGGRRRATDPIDYSVGLTEMARLGASVDGQQPLAVIHANNEDDWQQAADAVRAAITLGQKAAEETPVVYRRITE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: CYB_SCHCO
Sequence: MRLLKSNSLLRLVNSYLVDSPQPGNLSYMWNFGSLLAVCLVIQILTGCFLAMHYTAHVDLAFNSVEHIMRDVNNGWLIRYTHANVASFFFIFVYCHIARGLYYGSFKEPRTLTWSIGVIILILMMAIAFLGYVLPFGQMSLWGATVITNLMSAIPVYGQDIVELIWGGFSVSNATLNRFFSLHYILPFLLAALAVAHMIALHVHGSGNPNGLNAGDDRFPMHPYFIFKDLVTIFAFLLVLSIFVCFYPNALGHSDNYIPANPMVTPASIVPEWYLLPFYAILRSIPNKLLGVIAMFGSLLILLVLPLTDLSRVRGNQFRPLMKLSFWFFVVDFIILMWIGAEHPASPYLEVGQIATAFYFAWFVFIVPAVGLFENTMADINKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: 6PGD_STAAC
Sequence: MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFVNSLEKPRKILLMVQAGKATDATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAAKAKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMKLDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKELNGPKASFDGDKKDFLEKIRKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQDALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: PSAL_GRATL
Sequence: MSDFIQSYNNDPFLGNLSTPVSTSTFTKGLLNNLPAYRRGLSPLLRGLEIGMAHGYFLVGPFDKLGPLRNTDVALLSGFLSAVGLIIILTVCLSMYGNVSFDKDDAKDLLQTTEGWGQFTAGFLVGAVGGSGFAYLLLANIPVLQNLGLS
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: FLAV_BUCBP
Sequence: MESIGIFFGSDTGNTENVAKLIHKYIGTNISSIHDIANTNKKDIELFNILIFGVSTWYYGELQCDWDDFLPTLKKINFNNKIIALFGCGDQEDYSEYFCDGIGILYNVIRLSKNVRFIGSWTSKGYSFECSKALDKNKNFLGLVIDEDRQPEQSNQRIIQWTKKIKTELNSLLN
What is the function of this protein?
Low-potential electron donor to a number of redox enzymes.
What are the official names of this protein?
Flavodoxin.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family.
Protein: MDTC_ECOLU
Sequence: MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWGLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPHDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y048_AFV2P
Sequence: MRKAIVCFTIDANEKSLLSQLAERENKSLSQYVREIVLDRMIEELNEN
What are the official names of this protein?
Uncharacterized protein ORF48.
Protein: DCTN4_MOUSE
Sequence: MASLLQSERVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSQHTIHVVDKYSLGTRLQRPRAGASISTLAGLSLREGEDQKEVKIEPAQAVAEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDLQPVSASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECDEGDPDNINSTAKVVVPPKELILAGKDAAAEYDELAEPQDFQDDPDIVAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPVEEGDQGTEVIWLTQHVELSFGPLLP
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Dynactin subunit 4, Dynactin subunit p62.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (PubMed:19109891).
Protein: SYT_LEUMM
Sequence: MAEISLTFPDGAIKKFDEGIKPIGVAESISKSLAKKSVSGKINGSYIGMNDVITESGDFQLITTSDSEALDLLRHSASHLLAQALKRIPKFANIHFGVGPFIENGFYYDTDNGAGNQVSIEDFPEIEAIMHKIVKEDLPILSREITRDEALEIFADDPYKVELVNDLPVDEKITIAVQGDHIELDKGGLVPSTGWIKHFKLTSVAGAYWRGDSSNPMMQRVYGTAFWKAADVEAEIARREEAKERDHRVIGRDLDLFFTSQEVGSGLPVWLPNGATIRRQVERYITDKELSNGYQHVYTPVLSNLNLYKTSGHWDHYREDMFPPMDMGDGEFLELRPMNCPSHIMVFNHKPRSYRELPMRIAELGMMHRYEKSGALTGLSRVREMTLNDGHTFVEPEKLEEEFKSILTMMMGVYRDFNIKDYRFRLSYRDPKNTEKYFDDDEMWEKSQKQLKTAMDDLGLDYFEAEGEAAFYGPKLDVQTKTALGNEETLSTIQLDFLLPERFDLKYIGRDGLDNHRPVMLHRGIVGTMERFTAYLIEMYKGAFPTWLSPLQVQIIPVNLGAHGNYANAVQQKLQDAGLRANVETKDAKMGYLIREAQTNKIPYTLVLGDSEVNSNTVTVRKYGDTKTVTMSYDEFQYLILSDVSNYSRETE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF52_HHV8P
Sequence: MAAPRGRPKKDLTMEDLTAKISQLTVENRELRKALGSTADPRDRPLTATEKEAQLTATVGALSAAAAKKIEARVRTIFSKVVTQKQVDDALKGLSLRIDVCMSDGGTAKPPPGANNRRRRGASTTRAGVDD
What is the function of this protein?
Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA (PubMed:26320998, PubMed:34015248, PubMed:34387695).  Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells (PubMed:34015248, PubMed:34387695).  DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (PubMed:34015248, PubMed:34387695).  Targets also the HDP-RNP complex composed of DNA-PK subunits and paraspeckle proteins (PubMed:28712728).  This complex is a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway (PubMed:28712728).
What are the official names of this protein?
Tegument protein ORF52, Kaposi's sarcoma-associated herpesvirus inhibitor of cGAS, KicGAS.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae BLRF2 family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion tegument.
Protein: RR4_SISST
Sequence: RFKKIRRLGALPGLTNKRPRSGSDLKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPRDIITTKDKQRSKALIQNSIASSPHEELPNHLTIDLFQYKGLVNQIIDSKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS21_CHLTB
Sequence: MPSVKVRVGEPIDRALRILKKKIDKEGILKTSKSHRFYDKPSVKKRAKSKAAAKYRGR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ASB18_HUMAN
Sequence: MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSAQLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 18, ASB-18.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
Protein: MNMG_LEPCP
Sequence: MLYPQEFDVIVVGGGHAGTEAALAAARMGCDTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDESGIQFRILNSSKGPAVRATRAQADRILYKAAIRQRLENQPHLWLFQQAVDDLMVEGDRVVGAVTQVGIRFRARTVVLTAGTFLDGKIHVGLNNYPAGRAGDPPAVSLSARLKELKLPQGRLKTGTPPRIDGRSIDFSKLIEQPGDGVAAADGTPASSPMPVFSFLGSAAQHPRQMPCWITNTNQRTHDILRTGFDRSPMFTGVIEGVGPRYCPSIEDKINRFADKNSHQIFLEPEGLTTNEYYPNGISTSLPFDIQLAAVRTMLGMENAYILRPGYAIEYDYFDPRELKTSFESKAIGGLFFAGQINGTTGYEEAAAQGLYAGANAALQAQGNPPLSFGRDQAYLGVLVDDLITKGVTEPYRMFTSRAEFRLQLREDNADMRLTEIGRSVGLVDDVRWDAFNRKRDAVSRETERLKSTWVHPAILPAADSERLFGKALEHEYNLADLMRRPGISYDTVAEALTIARPGNYVSRETLNSQLGADLAAAVIEQLEIAIKYAGYIDKQNEDVQRAAHYEHLRLPDELDYAQVTALSFEVRQKLTKHRPETLGQASRISGVTPAALSLLLIHLKRGRFKGFTGNDKVAAGPISADAVNTDINDNPAHAATDAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_BARHE
Sequence: MSENNNDKITVKRTLTLKRSVLETSTVKQNFSHGRTKAVVVETKRRKITRTDEKAETPQPITKPHVAPQRSRPRFEDAKPNEPTAKSNLSSAEIEARLRALEEAHIQERIIREQAEEEARRAKEREESLRQTIQKTEIDETPQEEEEPTLQTQTPSLSPAQSQIEPINIPITPKNTTVIEKRKADETKEDDRNSRRTNLAKSEVRAPKVLKGADEKRRGKITLNSALDEEGSARGRSMAAMRRRQEKFKRAQNQEPKEKISREVILPETITIQELAQRMTERSVDVIKFLMKQGQMMKPGDVIDADVAELIAVEFGHTVKRVLESDVEEGIFNIADNPQKMQLRPPVVTIMGHVDHGKTSLLDAIRKANVVSGEAGGITQHIGAYQVEKNGQKITFIDTPGHAAFTAMRARGARVTDIAVLVVAADDSVMPQTIESINHAKAAGVPIIVAINKIDKPTANAQKVRTELLHHEVFVETMGGETLEVEVSAKTGQNLDKLLEAILLQAEILDLKADPQRTAEGVVIEAKLDRGRGSVATVLVQKGTLHPSDIIVAGNEWGRVRALIDDHGRHVKEAVPSTPIEILGMQGTPQAGDRFAVVTHEAKAREIAEYRQRLARDKAVARQTGSRGSLEQMMSKLQTTGVKEFPLIIKGDVQGSIEAIASALEKLGNEEVRARIVHSAAGGITESDISLAEASHSAVIGFNVRANKQARDCAKTQGIEIRYYNIIYDLVDDIKAAMSGLRSPEQRETFLGNAEILEVFNITKIGKVAGCLVTEGKIERGAGVRLIRDNIVIHEGKLKTLKRFKDEVNEVQSGQECGIAFENYEDIRTGDIIETFHIEHINRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_SALRD
Sequence: MAHKKAMGSTENTRDSNPSYLGVKSYGGEHVHAGSIIVRQRGTKFHPGHNVGRGSDDTLFAKDHGVVKFARSGGDRKYVHVVPEEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.