PharMolix/UniProtQA huggingface dataset:
Protein: NKD1_HUMAN
Sequence: MGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIGRSTRELVGDVLRDTLSEEEEDDFRLEVALPPEKTDGLGSGDEKKMERVSEPCPGSKKQLKFEELQCDVSMEEDSRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKMLRVKLTVAPDGSQSKRSVLVNQADLQSARPRAETKPTEDLRSWEKKQRAPLRFQGDSRLEQSGCYHHCVDENIERRNHYLDLAGIENYTSQFGPGSPSVAQKSELPPRTSNPTRSRSHEPEAIHIPHRKPQGVDPASFHFLDTPIAKVSELQQRLRGTQDGSKHFVRSPKAQGKSVGVGHVARGARNKPPLGPAIPAVSPSAHLAASPALLPSLAPLGHKKHKHRAKESQQGCRGLQAPLASGGPVLGREHLRELPALVVYESQAGQPVQRHEHHHHHEHHHHYHHFYQT
What is the function of this protein?
Cell autonomous antagonist of the canonical Wnt signaling pathway.  May activate a second Wnt signaling pathway that controls planar cell polarity.
What are the official names of this protein?
Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1.
What is the protein family that this protein belongs to?
Belongs to the NKD family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm.
Protein: CAPP_MARN8
Sequence: MTELHPDLRENVRLLGDLLGQSILRFPGQDCYDRIEEIRAAAKADRRQESGSGQRLVKLLGQLSDDELLPVTRAFNQFLNLANLAEQYHGIRRKQGHPSDLMVESLGEVFDRLKSGGIDPQELHRKVADLRIEFVLTAHPTEVARRTLILKYDEMSDCLSRLDHDDLMPGEREEIVDRLSLLIAEAWHTDEIRHERPTAVDEAKWGFAVIENSLWQALPKFLRSLDTSLSEATGQGLPLQVSPIRIASWMGGDRDGNPNVTHEVTREVFLLGRWMAADLYLRDIQALRAELSMWQASDELRAEVGDSREPYRQVLAQLRERLIKTREWAEASVKGEPADDSGILFENEDLTGPLELCYRSLMECGLETIANGPLLDTIRRAHTFGLPLIRLDIRQEASRHAEAVAEMVNYLGLGDYLSWSEQERQAFLVKELKGRRPLVPRNWQPSEPVREVLATCEVVAGQTPEALGSYVISMASKPSDVLNVILLLREAGMAFPMRVVPLFETLDDLKGAPDSMAALYEVDWYREYCSGRQEVMIGYSDSSKDAGQLMAAWAQYQAQEKLTEVANRYGVHLTLFHGRGGTVGRGGGPANRAILSQPPGSVNGSFRITEQGEMIRFKFGLPRLAVQSLTLYTTAVIEATLAPPPVPKDEWREVMDWLTERSLRSYREVVRENPDFVPYFRQVTPETALGKLALGSRPARRKATGGVESLRAIPWIFAWTQMRLMLPSWLGSDVALEQAAQADRLPELREMMQGWPFFRTYVDMLEMVLAKADLRIASYYEQTLVEDEHLLALGQSLRQRLQGCIERLLELKQQQTLLEQEPVFAHSMKVRNPYTDPLHYLQAELLRRDRESEGAGKVPELVERALKVTMAGISAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: CA198_HUMAN
Sequence: MASMAAAIAASRSAVMSGNRPLDDRERKRFTYFSSLSPMARKIMQDKEKIREKYGPEWARLPPAQQDEIIDRCLVGPRAPAPRDPGDSEELTRFPGLRGPTGQKVVRFGDEDLTWQDEHSAPFSWETKSQMEFSISALSIQEPSNGTAASEPRPLSKASQGSQALKSSQGSRSSSLDALGPTRKEEEASFWKINAERSRGEGPEAEFQSLTPSQIKSMEKGEKVLPPCYRQEPAPKDREAKVERPSTLRQEQRPLPNVSTERERPQPVQAFSSALHEAAPSQLEGKLPSPDVRQDDGEDTLFSEPKFAQVSSSNVVLKTGFDFLDNW
What are the official names of this protein?
Uncharacterized protein C1orf198.
Protein: DAPF_METM6
Sequence: MKFTKMHGLGNDYIYVDAISQKIENPNEISRFVSDRHFGIGSDGLVLILPSDLADFKMRMFNSDGSEAEMCGNAIRCVGKFVYDKKMTDKSTITIETLAGIKVLEMTIENDKVVLVKVDMGEPILKAETIPVLSEKHPVIDEEITAKDYCYNFTCVSIGNPHAITYIENVEEFPLEKIGPLFEIHEKFPRKTNVEFVELIDDSTVKMRVWERGAGETLACGTGACAVLVASVLKGYVGRKATVKLLGGDLTIEWNESDNHIYMTGPATTVFEGEIDI
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHMA2_MYCTU
Sequence: MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase 2.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: CYSC2_BACSU
Sequence: MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLANAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMILTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTGIDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Probable adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: PETG_LOTJA
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACHE_XENLA
Sequence: MESGVRILSLLILLHNSLASESEESRLIKHLFTSYDQKARPSKGLDDVVPVTLKLTLTNLIDLNEKEETLTTNVWVQIAWNDDRLVWNVTDYGGIGFVPVPHDIMWLPDIVLENNIDGNFEVAYYANVLVYNTGYIYWLPPAIFRSTCNIEITYFPFDWQNCSLVFRSKTYSANEIDLQLVTDDETGLPFDQVDIDREAFTENGEWAIMHRPARKILNPKYSKEDLRYQEIVFNLIIQRKPLFYIINIIVPCVLISFLVVLVYFLPAKAGGQKCTVSISVLLAQTVFLFLIAQMVPETSLSVPLIGKYLMFVMFVSTLIVLSCVIVLNVSLRSPSTHNLSTKVKHMLLEVLPQFLHLRVEPCDEGEETPRERRRSSLGIMLKAEEYVLKKPRSELMFERQRERHGMRREPDGYRADGFDVGVTTTLYRNLAQCAPEIKDCVDACNFITQNTKEQNRTGSEMENWILIGKVLDVLCFWVALPLFVLGTLAIFLMGHFNTAPEHPF
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: GLNA1_METMA
Sequence: MVQMKKCTTKEDVLEAVKERDVKFIRTQFTDTLGIIKSWAIPAEQLEEAFENGVMFDGSSIQGFTRIEESDMKLALDPSTFRILPWRPATGAVARILGDVYLPDGNPFKGDPRYVLKTAIKEAEKMGFSMNVGPELEFFLFKLDANGNPTTELTDQGGYFDFAPLDRAQDVRRDIDYALEHMGFQIEASHHEVAPSQHEIDFRFGDVLCTADNVVTFKYVVKSIAYHKGYYASFMPKPLFGVNGSGMHSNQSLFKDGKNVFYDPDTPTKLSQDAMYYIGGLLKHIREFTAVTNPVVNSYKRLVPGYEAPVYISWSAQNRSSLIRIPATRGNGTRIELRCPDPACNPYLAFALMLRAGLEGIKNKIDPGEPTNVNIFHLSDKEREERGIRSLPADLKEAIDEMKGSKFVKEALGEHVFSHYLCAKEMEWDEYKAVVHPWELSRYLSML
What is the function of this protein?
Probably involved in nitrogen metabolism via ammonium assimilation.  Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD53_BOVIN
Sequence: MGMSSLKLLKFVLFFFNLIFWFCGCCILGLGIYLLIHSKFGVLFHNLPSLTLGNVLVIVGSVIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTLAILLFVYEQKLKEYVAEGLTESIQRYNSDNSTKAAWDSIQSFLQCCGVNGTSDWTSGPPASCPKGSAVKGCYIQAKQWFHSNFLYIGITTICVCVIQVLGMSFALTLNCQIDKTSQVLGL
What is the function of this protein?
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion.  May be involved in growth regulation in hematopoietic cells (By similarity).
What are the official names of this protein?
Leukocyte surface antigen CD53, Cell surface glycoprotein CD53.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
Protein: XPP2_HUMAN
Sequence: MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV
What is the function of this protein?
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.  May play a role in the metabolism of the vasodilator bradykinin.
What are the official names of this protein?
Xaa-Pro aminopeptidase 2, Aminoacylproline aminopeptidase, Membrane-bound aminopeptidase P, Membrane-bound APP, Membrane-bound AmP, mAmP, X-Pro aminopeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: DEOD_BACCE
Sequence: MSVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFTGEETTSEERQTTFNEMIEIALDAAIQQ
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: HEM1_CANGA
Sequence: MFRPVLKVRPSFSYPYSIVSSRSVRLASTATANANTAAATSTVAAHGTQETPFDFEGHFESELAKKRLDKSYRYFNNINRLAKEFPLAHRQLEDDKVTVWCSNDYLALSKNPQVLDAMRKTIDKYGAGAGGTRNIAGHNIPTMRLEAELAALHKKEGALVFSSCYVANDAVISLLGQKVKDLVIFSDELNHASMIVGIKHANRPKHIFRHNDLAQLEEMLQMYPKSTPKLIAFESVYSMAGSVADINKICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFEAHRVAGIATPPQGDNGRLRTVMDRVDMITGTLGKSFGTVGGYVAASSKLIDWVRSYAPGFIFTTTLPPAVMAGAAEAIRFQRSHLNLRQDQQRHTAYVKKGLHDLGIPVIPNPSHIVPVLIGNPDLAKQASDILMEKHRIYVQAINFPTVSRGTERLRITPTPGHTNDLSDILIAAVDDVFNELQLPRIRDWEMQGGLLGVGDKNFVPEPNLWTEEQLSFSNEDLNSNVFEPVIDQLEVSSGVKL
What is the function of this protein?
Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
What are the official names of this protein?
5-aminolevulinate synthase, mitochondrial, 5-aminolevulinic acid synthase, Delta-ALA synthase, Delta-aminolevulinate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MURG_THEFY
Sequence: MRVVLAGGGTAGHVEPALALADALRRINPDTQVLCLGTKRGLEQRLVPMRGYELAEIPAVPLPRKLTPQLLSVPGRLANAISTAAKHLDRVQADILVGFGGYVATPGYLAARSRRIPIVVHEANPLPGLANRLGARLTPHVFTGHPHTEIRNGRYIGIPLRTRISNLDRLAVGDKARSKFGLRPDLPTLLIFGGSQGAQAINQAAFDSAEDFYQAGIQVLHVVGPKNADGPEDRTRGGVPYVVVPYVDEMELAYAAADIAMCRSGALTCAELTAVGLPAVFVPLAIGNGEQRLNAEPIVQAGGGLMVANSELSRDWIREHLIPLLTDTDRIVAMSEAAARLGRRDADMALAREVIAIARGERPTPEMPIDYSEESGDTR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YHAM_SALTY
Sequence: MFESKINPLWQSFILAVQEEVKPALGCTEPISLALAAAAAAAELNGTVERIDAWVSPNLMKNGMGVTVPGTGMVGLPIAAALGALGGDAKAGLEVLKDASAKAVADAKAMLAAGHVAVMLQEPCNDILFSRAKVYSGDSWACVTIVGDHTNIVRIETDKGVVFTQADNAQEEEKTSPLGVLSHTSLEEILAFVNAVPFDAIRFILDAARLNGALSQEGLRGSWGLHIGSTLAKQCDRGLLAKDLSTAILIRTSAASDARMGGATLPAMSNSGSGNQGITATVPVMVVAEHVGADDERLARALMLSHLSAIYIHHQLPRLSALCAATTAAMGAAAGMAWLIDGRYDTIAMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHNVEQSISNLCSLACRSMQQTDKQIIEIMASKAH
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: Y2129_PSYWF
Sequence: MSANESVVTADLKPRVPSTGSVDVLIVSGRSGSGKTSVLNILEDLGYYVIDNMPLSLLSDAAHKLTEDGGITNLALGVDIRTLKADSASFSAIYDTLLNSYGPDKVRIMYVTAQESVLVARFAATRRVHPLMAVNDYEIKNLPSAIIKETETLRPISGNADITIDTSQLNIHQLKELVREYVGADNQITVNVLSFGFKYGVPIDADFVFDVRILPNPHWEPQLRVKTGKDTEVAAFFANFPQVEEMKQDIYRYLDRWLPEFLHNNRHTVTVAVGCTGGKHRSVFLAESLYSMLSESLPREIKVMVKHREKAHWKA
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PsycPRwf_2129.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RS15_CAMHC
Sequence: MALDTAQKAQIVAKFARKEKDTGSSEVQIALLSARIDSITEHMQNNPKDFSSRLGLLKLVGQRKRLMKYLKSTNYGAYSKLVNELNLKDK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ROBO3_HUMAN
Sequence: MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQKRREEPR
What is the function of this protein?
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity).  In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity).  Required for hindbrain axon midline crossing (PubMed:15105459).
What are the official names of this protein?
Roundabout homolog 3, Roundabout-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ROBO family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: RS29_LYSTE
Sequence: MGFENIWFSHPRKYGQGSRSCRSCANKHGIIRKYGLNICRQCFREYASDIGFKKLD
What are the official names of this protein?
40S ribosomal protein S29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: Y077_OSHVF
Sequence: MMRKYLILLILLPALAVGIIPDVTTTVGDMVDTSYLIVNCRADIGTQELPPTKLELSSDKIKFTATDLSSTSTQACERSIVVTKTGLNILRVAGVDEFGYTAEAIDENKYIASCVINDEDKINRVLRIKITHPAMFDYTEWVCKTTASDGVETTARGGIDTGAILFDFENSDMELRTNGMKKDKKTLPMTFDCLIDGPFKTVIKQEIYGHKLPLFGVDMVLKKGNGDTSRIRGELFGRNKIDIDETPPLDDFTIRKESDLCGDTTRLKEITLAATNNNEFAANNIVIFLNTGFTNDDNSRTNYHNDQKKENAVLDPYRELLKTECFGRHTKTMVTTPINQLQHDTQCFRYDFIGSAQFISDNGHILAGVNKLSLHGGLINPTEEYDLTLNWEEDMDFQTERILLEMPSKIGAIYTGVRTGMPLRVVIPTHNLISDLYKEVAEAMVSFNRMEIKMLKLDQNKIAEVSCNSHKPFFYKAIVIMQKGCWIDTIDAPSRCLNTDDNRAFKVVTIEDYTFYLRRKIHSQYRDAVYGRDMDYRCMGSYYYCFSDYRRYNKLRDMVVVEQPIDTKLTNTILAASNAKYSSECVQDNVENLVQADFNVKGYTDGIADNLITHINTDLNMGSTMARKFPIAEITNSDVKCHCGQVVNTCNRYSFTNAINTLGTIYQPNTFPLVLTGSNNRESTMWCESMGFRSPIKKAKIMAANFACGGSTTPFIDFSDDLLNYLPTPIFTTVKDLTAAPEKRYIIECKDIPTACLSESSISINIIMDWIYDPPKTQSELGLDSEPEATGKTYKSKRVIWQKTNGPIFGGEFKIERASFYTNAFTNQPELYKNTVLPEDELFDYISDGYTHTFFKTYFPENEIKPTSATCSYGKINILKTATITDFSSWITTDKQVLCTGSNYQYNVKRIGNKIFTTDVTWPNDCPSVDNVKIELLSNNEADLLYSVVCSSQGTAIIDGLKTITYSEDPIPMDSHMDGNVAYCIPTDNGIKVVLATNLRDEYVNSLKLRTGYQINELSINQIDTAQVDTLGQGCITPPRHYPIDIAVDSTGIPQSFVFDCTIPEYLQSSMDTNPATCTSFPEVETVKLVIVYSGVFSSSVKHTIAMRGRTKGPCSGLANTECELLPQVNGLDKGIRYTIKDIYFSNLFKNTPGLSVRAYCTLPNIAETNTVTKELSKTMTRIKLRVPQNAPPETPHYDTEYMYKGVNRFYYYMSYTVLGVVVITILTMSIILCLKFRVKMKLSRQQMTSTGEGQQMLYIHAEV
What are the official names of this protein?
Uncharacterized protein ORF77.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: RL13_YERPY
Sequence: MKTFTAKPETVKRDWYVVDASGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNAEKVAVTGNKRTDKIYYHHTGFVGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGTEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PYRG2_MOUSE
Sequence: MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVDGNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGICLGMQLAVIEFARNCLNLKDANSTEFEPNTPVPLVIDMPEHNPGDLGGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIVELTSHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYSDGYSDASDDSFPEAKLAELDLN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).
What are the official names of this protein?
CTP synthase 2, CTP synthetase 2, CTPsH, UTP--ammonia ligase 2.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CS13A_LEPBD
Sequence: MKVTKVGGISHKKYTSEGRLVKSESEENRTDERLSALLNMRLDMYIKNPSSTETKENQKRIGKLKKFFSNKMVYLKDNTLSLKNGKKENIDREYSETDILESDVRDKKNFAVLKKIYLNENVNSEELEVFRNDIKKKLNKINSLKYSFEKNKANYQKINENNIEKVEGKSKRNIIYDYYRESAKRDAYVSNVKEAFDKLYKEEDIAKLVLEIENLTKLEKYKIREFYHEIIGRKNDKENFAKIIYEEIQNVNNMKELIEKVPDMSELKKSQVFYKYYLDKEELNDKNIKYAFCHFVEIEMSQLLKNYVYKRLSNISNDKIKRIFEYQNLKKLIENKLLNKLDTYVRNCGKYNYYLQDGEIATSDFIARNRQNEAFLRNIIGVSSVAYFSLRNILETENENDITGRMRGKTVKNNKGEEKYVSGEVDKIYNENKKNEVKENLKMFYSYDFNMDNKNEIEDFFANIDEAISSIRHGIVHFNLELEGKDIFAFKNIAPSEISKKMFQNEINEKKLKLKIFRQLNSANVFRYLEKYKILNYLKRTRFEFVNKNIPFVPSFTKLYSRIDDLKNSLGIYWKTPKTNDDNKTKEIIDAQIYLLKNIYYGEFLNYFMSNNGNFFEISKEIIELNKNDKRNLKTGFYKLQKFEDIQEKIPKEYLANIQSLYMINAGNQDEEEKDTYIDFIQKIFLKGFMTYLANNGRLSLIYIGSDEETNTSLAEKKQEFDKFLKKYEQNNNIKIPYEINEFLREIKLGNILKYTERLNMFYLILKLLNHKELTNLKGSLEKYQSANKEEAFSDQLELINLLNLDNNRVTEDFELEADEIGKFLDFNGNKVKDNKELKKFDTNKIYFDGENIIKHRAFYNIKKYGMLNLLEKIADKAGYKISIEELKKYSNKKNEIEKNHKMQENLHRKYARPRKDEKFTDEDYESYKQAIENIEEYTHLKNKVEFNELNLLQGLLLRILHRLVGYTSIWERDLRFRLKGEFPENQYIEEIFNFENKKNVKYKGGQIVEKYIKFYKELHQNDEVKINKYSSANIKVLKQEKKDLYIRNYIAHFNYIPHAEISLLEVLENLRKLLSYDRKLKNAVMKSVVDILKEYGFVATFKIGADKKIGIQTLESEKIVHLKNLKKKKLMTDRNSEELCKLVKIMFEYKMEEKKSEN
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements (spacer sequences) and target invading nucleic acids.  Unlike many single-component effectors, this CRISPR-Cas system targets RNA (PubMed:27669025).  CRISPR clusters are transcribed from pre-CRISPR RNA (crRNA) and processed into crRNA by this protein (PubMed:27669025, PubMed:28475872, PubMed:28757251).  pre-crRNA processing yields a 5'-OH and probably a 2',3'-cyclic phosphate (PubMed:27669025).  Also cleaves pre-crRNA from several other type VI-A CRISPR systems (PubMed:28475872).  Cleaves linear target ssRNA in a crRNA-dependent fashion, preferentially before U residues (PubMed:27669025, PubMed:28475872).  Cleavage of target ssRNA is about 80-fold faster than pre-crRNA processing and uses a different active site (PubMed:27669025).  Binding a viable target RNA target activates this protein for non-specific RNA degradation in vitro (called collateral RNA degradation) (PubMed:27669025, PubMed:28475872, PubMed:28757251).  Activation occurs with 10 fM target RNA (PubMed:28475872).  crRNA maturation is not essential for activation of RNA degradation, but lack of mature crRNA (due to mutagenesis) decreases activation levels (PubMed:28475872).  This system has a 3' protospacer flanking site in the target RNA (PFS), which is C and unavailable to base pair with crRNA (PFS is equivalent to PAM, the protospacer adjacent motif) (PubMed:28757251).
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas13a, CRISPR-associated endoribonuclease C2c2, EndoRNase, LbuC2c2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas13a family.
Protein: TCPB_BRUMB
Sequence: MSSYSSNIDRLQREIARLKADDSREMSKEKQAQSKAHKAQQAISSAKSLSTQKSKMSELERATRDGAAIGKKRADIAKKIADKAKQLSSYQAKQFKADEQAVKKVAQEQKRLSDERTKHEAFIKQSLSSMRTTASATMEAEEEYDFFISHASEDKEAFVQDLVAALRDLGAKIFYDAYTLKVGDSLRRKIDQGLANSKFGIVVLSEHFFSKQWPARELDGLTAMEIGGQTRILPIWHKVSYDEVRRFSPSLADKVALNTSLKSVEEIAKELHSLI
What is the function of this protein?
Virulence factor that interferes with host Toll-like receptor 2 (TLR2) and TLR4 signaling, resulting in the reduction of dendritic cell maturation, inhibition of pro-inflammatory cytokine secretion and impaired NF-kappa-B activation in macrophages.  Binds host lipids.  Has NAD(+) hydrolase (NADase) activity, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR (probably 2'cADPR).
What are the official names of this protein?
Probable 2' cyclic ADP-D-ribose synthase TcpB, 2'cADPR synthase TcpB, Brucella TIR-containing protein 1, Btp1, NAD(+) hydrolase TcpB, TIR domain-containing protein in Brucella, TcpB.