PharMolix/UniProtQA huggingface dataset:
Protein: GFAP_MOUSE
Sequence: MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQKLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKDSKQEHKDVVM
What is the function of this protein?
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
What are the official names of this protein?
Glial fibrillary acidic protein, GFAP.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with intermediate filaments.
Protein: PRND_SHEEP
Sequence: MRKHLGGCWLAIVCVLLFSQLSSVKARGIKHRIKWNRKVLPSTSQVTEAHTAEIRPGAFIKQGRKLDINFGVEGNRYYEANYWQFPDGIHYNGCSEANVTKEKFVTSCINATQVANQEELSREKQDNKLYQRVLWQLIRELCSIKHCDFWLERGAGLQVTLDQPMMLCLLVFIWFIVK
What is the function of this protein?
Required for normal acrosome reaction and for normal male fertility (By similarity).  Can bind Cu(2+) (By similarity).
What are the official names of this protein?
Prion-like protein doppel, PrPLP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: COPB_SHIFL
Sequence: MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRLDILK
What is the function of this protein?
This protein is involved in the determination of copy number in gene replication.  It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity).
What are the official names of this protein?
Replication regulatory protein repA2, Protein CopB.
Protein: SC5AA_PIG
Sequence: MAADNSSSDPHAPGPQLSVADVVIVAVYFAVNMAVGVWSSCRASRNTVSGYFLAGRDMMWRPIGASLFASSEGSGLFVGLAGSGAAGGLAVAGFEWHATYVLLALAWVFVPIYISSEIVTMPEYIQKRYGGQRIRMYLSVLSLLLSIFTKISIDLYAGALFVHICLGWNFYLSTCLMLVITALYTIAGGLAAVIYTDALQTLIMVVGAVILTVKAFQQIGGYEQLAAAYAQAIPSKTISNTTCHLPRADAMHMFRDPATGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDVWRRLRPRAGERELLLVGRLVIVVLIGVSVAWIPVLQGSNSGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMVGLAVGAWRLVLEFLHPAPPCGHPDVRPALLRTVHYLHFAVALFVLSGAVVAAVSLLTPPPAGVQIENLTWWTLARDRPSGAKTGDGPASQKHAFWARVCSLNAVLLVCVNLFFYAYFA
What is the function of this protein?
Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1.  Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump.  Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (By similarity).  Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins.  Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (By similarity).
What are the official names of this protein?
Sodium/mannose cotransporter SLC5A10, Sodium/glucose cotransporter 5, Na(+)/glucose cotransporter 5, Solute carrier family 5 member 10.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ME53_NPVAC
Sequence: MNRFFRENNIFDAPRTGGKGRAKSLPAPAANSPPSPVRPPPKSNIKPPTRISPPKQPMCTSPAKPLEHSSIVSKKPVVNRKDGYFVPPEFGNKFEGLPAYSDKLDFKQERDLRMHFMSDLERDIMKATLKFSTNYIMGYINSKDMRMTGKFASRPVKYKKTMEHMSDSRCTTCNYRFKDNTREWFLYVVVHIEKPLDDPDRIDICCQKCYLYHNVPKTSYEIYPSINLVDLSYLARERFFYQYIFPVSLEHTTEVKELRIDDHNCKVFEIIRRIIRNHKEPNERIQTIDLSTTGGLVLRETYTNIVLQRYRSMCTRPDVVDDVNCFILQEPSEMMAALQDNRFSGIKGTVFATVKVKKFTQVLDGAITFPLKPTTNNYCKLCKKTKLYYKNPVLYCTKCGFTNVYHFPEYSKFMYYFEAIKSFEMHNEMIIYYDLKMYKKLINIVNNNV
What is the function of this protein?
May act as a packaging protein or as a structural component associated with intranuclear baculovirus virion assembly.
What are the official names of this protein?
Early 53 kDa protein, ME-53.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Host cell membrane. Note=Colocalizes with protein GP64.
Protein: ILVD_VESOH
Sequence: MCIPRKYSSQVVDGFERAPSRAMLYPIGFKKDDFSKPQVGIASTWSMVTPCNMHINKLADKAEKGINNAGGKGVIFNTITISDGISMGSEGMKYSLVSREVIADSIETVVGCQGFDGVVAIGGCDKNMPGCIIGLARLNRPSIFVYGGTIQPGKNRTDVVSVFEAVGRFSNHEIDEIELENIEKTAVTGAGSCGGMYTANTMASAIEALGMSLPNSSAQNAISDDKNNDCIQAGEAILTLLNKDIKPRDIMTMKAFENAITVIIALGGSTNAVLHLIAMANAAEVNLKIDDFTRIGKKVPVIADLKPSGKYMMSELVEIGGTLPLMKMLLDAGLLHGDCMTVTGKTLAKNLKNVQSYADSQEIIRALDNPIKKDSHLRILRGNLAINGAVAKITGKEGSSFKGTAKCFSHEEGALKAILNDQIKAGNVIVIRYEGPVGGPGMREMLAPTSAVMGKGLGGKIALITDGRFSGGTHGFVVGHITPEAFKGGVLAVVEDGDEIIIDAQNNVLELLVDQAIIDKRLSKWTQPKPNYTKGVLAKFAKLAKSASEGAVTD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: KS6AA_CHICK
Sequence: MPLAQLAEPWPNMELVQLDTENGQAAPEEGGNPPCKAKSDITWVEKDLVDSTDKGEGVVKEINITHHVKEGSEKADPSQFELLKVLGQGSFGKVFLVRKITPPDSNHLYAMKVLKKATLKVRDRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSAEAQSLLRALFKRNPANRLGSGPDGAEEIKRHPFYSTIDWNKLYRREIKPPFKPAVGQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDSKVKPAQPPLHSVVQQLHGKNIQFSDGYVVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDSLPQSQLNYQDVQLVKGAMAATYSALNSSKPSPQLKPIESSILAQRRVKKLPSTTL
What is the function of this protein?
Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription.
What are the official names of this protein?
Ribosomal protein S6 kinase 2 alpha, MAP kinase-activated protein kinase 1, MAPK-activated protein kinase 1, MAPKAP kinase 1, MAPKAPK-1, Ribosomal protein S6 kinase II alpha, S6KII-alpha, p90-RSK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Protein: RABP2_BOVIN
Sequence: MPNFSGNWKIIRSENFEDLLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKIGEEFEEQTVDGRPCKSLVKWESENKMVCEQRLLKGEGPKTSWTRELTNDGELILTMTADDIVCTRVYVRE
What is the function of this protein?
Transports retinoic acid to the nucleus.  Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity).
What are the official names of this protein?
Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Protein: TFE_ARCFU
Sequence: MKAETTTGVEELLNELVGRAAGEVGLILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRRDDETGWMEYYWRINYDKALDVLKRELEKTAKKLREKIEAETSTIYYICPNMCVKVSYNDAMELNFTCPRCGAMLDYLDCSKAIEKIEEEVRRIEEILESLDKNSG
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: COX1_MARPO
Sequence: MNNFAQRWLFSTNHKDIGTLYLIFGAIAGVMGTCFSVLIRMELAQPGNQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGSPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGCGSGWTVYPPLSGITSHSGGSVDLAIFSLHLSGVSSILGSINFITTIFNMRAPGLTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFIVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTVGGLTGIVLANSGVDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWIGKITGLQYPETLGQIHFWITFFGVNLTFFPMHFLGLAGMPRRIPDYPDAYAGWNAFSSFGSYVSVVGIFCFFVVVFLTLTSENKCAPSPWAVEQNSTTLEWMVPSPPAFHTFEELPAIKESI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UVRB_STRPM
Sequence: MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTIGEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDGRSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRREEFESHVHQIIYVSATPGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADKMTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGLISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEAAELLDFELAAQMRDLILELKLMD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MST2_DROHY
Sequence: MSLCRCSSICLRRPILRSFNFLNKYIDQSQHSGGLSSFQRLSFSNTGKNESTDDSNQIRCDADKTAADKKKQKQKEEEQAKIREYKRECLKVQKRVLAEEIRCSGEKDRILIQGMMKCLTDGMKKACTKIAKAKLIADKELAVQCAALSKKDKVKALLKKCEREKSKEKECNQNSPAEGDKDRTKKGKTKGKSGGGNKKRSTKENRAKKGKKLVKNRFTQKLEHCIKSEWADVCECRQNFTEDERKRLAASYKCMGTKIKSICRKRVIAEMCEAAGYVKSSEPKKKGKKKKNDEKKEKELEREILKEQAEEEAKIRGVVKEVKKKCKEKALKKKCKDLGRKMKEEAEKKKCAALAKKQKEEDEKKACKELAKKKKEADEKKKCEEAANKEKKAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEAAERKKCEELAKNIKKAAEKKKCKEAAKKEKEAAERKKCEELAKKIKKAAEKKKCEETAKKGKEVAERKKCEELAKKIKKAEIKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCEKAAKKRKEAAEKKKCEKSAKKRKEAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKEAAKKEKEAAEREKCGELAKKIKKAAEKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKEAAEKKKCEEAAKKEKEAAERKKCEELAKKIKKAAEKKKCKKLAKKKKAGEKNKLKKGNKKGKKALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKCEKTAKKRKEEAEKKKCEKTAKKRKEAAEKKKCEKAAKKRKEEAEKKKCEKTAKKRKETAEKKKCEKAAKKRKQAAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKELAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKKLAKKEKKAGEKNKLKKKAGKGKKKCKKLGKKSKRAAEKKKCAEAAKKEKEAATKKKCEERAKKQKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKRCEEAAKREKEAAEKKKCAEAAKKEKEATEKQKCAEAAKKEKEAAEKKKCAEAAKREKEAAQKKKCADLAKKEQEPAEMKKCEEAAKKEKEAAEKQKCAKAAKKEKEAAEKKKCAEAAKKEQEAAEKKKCAEAAKKEKEAEKKRKCEKAEKAAALKRQCAKLVIRAKEAALRKKCAIIAKKAKMAAEKKECEKLAKKAKEAIEWKKCAKLAKKKREAEKKKCAKLAKKEKEAAEKKKRCKDLAKNKKKGHKKKGRNENRKKRTDC
What is the function of this protein?
Possible structural role in the sperm tail.
What are the official names of this protein?
Axoneme-associated protein mst101(2).
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG_BURO0
Sequence: MNAPAPSSVRRTKKLPPLRVGIGGPVGSGKTTLLEMLCKAMRDRYDLVAITNDIYTKEDQRLLTVAGALPEERIMGVETGGCPHTAIREDASINLEAVDRMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLDVMASDTRKMRGERPYVMTNLKALDGVADVIAFIEKKGLLTV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
Protein: RUVB_SHEB5
Sequence: MIEADRLIQPQIQAQDESIDRAMRPKMLDEYTGQDHTRAQLKVFIQAAKNRNEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLESGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGALTSPLRARFGIPLRLEFYNIKDLSTIVTRSAQVMELDIDAEGAFEIARRSRGTPRIANRLLRRVRDYAQVKHDGAVTKFVAEHALDLLDVDSEGFDYMDRKLLLAIIDKFIGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATARAYQHFELIKPE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SP381_VANPO
Sequence: MAIRHVKRRYSESSESSSSDESVVDSTEISVDINDDDAVKPDNEESQLEGERDMATNDGMENNGCSDLSSDSEDSSSEESDEEPVFQRPIFIKRNQLAEVTDSNNQGNVLRRIEHENKVVEQNEEAKKQIATNYTTDKEILMKAMSLNDNDLIDPEGERLRWLERQKIRKEKYRKKLIDKQLELEEYEANKLLNRDIDKLEENTTTTTGEKDIPIKKSNRINNNKGDNEFKPKRVVNVTFKSLDDNETSAVANEDSEYSIL
What is the function of this protein?
Component of the spliceosome and rRNA processing machinery.  In association with the spliceosomal U4/U6. U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor SPP381.
What is the protein family that this protein belongs to?
Belongs to the SPP381 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS5_STAAW
Sequence: MIVIVDYGLGNISNVKRAIEHLGYEVVVSNTSKIIDQAETIILPGVGHFKDAMSEIKRLNLNAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGADIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAP22_PYRTR
Sequence: MAAKVADDVANLKLDDSNTKPASGAAENGDKPTGDAEHEDSDDDNEAEEGAPEAGEGAAKKKKKRKPRKKKKAGAAGAGGAKTQTAPPRVRIDEVFPNDSYPEGEIQEYVNENAYRTTNEEKRHLDRMNNDFLTEYRKGAEIHREVRQWAQKWIKPGMGLTEIAEGIEDSVRALTGHQGLGNGDAQIAGMGFPTGLSINHCAAHYTPNAGNKMVVNYEDVMKVDFGVHINGRIVDSAFTLTFDPVYDNLVNACKAATNAGIKEAGIDVRMSDIGAAIQEVMESYEVEIKGEMLPVKCIRNLNGHSIGHYTIHGGKTVPIVKGGDQTKMEEGETFAIETFGSTGKGYVRDDMETSHYAMKADAPKVALRVSSAKTLLNSITKNFGTLPFCRRYLDRMGHDKYLLGLNNLVSAGIVEAYPPLCDIKGSYTAQSEHTFVLRPTCKEVLSRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_NITWN
Sequence: MRVAPSGGPPHHHAMIRATPPKRRLKAGTINVAPSFMRERDLMECGVWPVAGCDEVGRGPLAGPVVAAAVVLDPNHIPKGIDDSKRLTAARREELFEEIVATASFAVACAPIERIDRDNILRASLWALARAVHALPDTPKHVFVDGRDRIDIACACEPVIGGDGLVLSIAAASIVAKVTRDRLMCKLARDCPGYGFETHKGYAVPGHLEALGRLGPSSHHRSFFAPVVAARERHRALLAGASASISETSATVAVEAVI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C18BA_PAEPP
Sequence: MNNNGNALSRTALTPTNNKVISGDLVTNGLPPIDNNIICSNGFMPINVTRKNPFRKRTTQEFIREWTEWKENSPSLFTAPIVGVVTSTLLEALKKQVQSRLLLLMTNLLFPNNSTSTMEEILRATEQYVQEQLDTVTWNRVSQELEGLKNNLRTFNDQIDDFLQNRVEISPTAMIDSINTMQQVFVNRLPQFQLSDYQLLLLPLFAQGATLHLTFIRDIIINAGEWNIPEAQLNTCKRYLKQYVAQYSNYALSTYEGAFRARFYPRATLENMLQFKTFMTLNVLDLVSIWSLLKYMNLYISTSANLYNIGDNKVNEGEYSISYWPFFNSYIQTKSNYVLSGVSGYAIRWYYLNTFFGEYIQDNLYNIIASYVGGVNGPKIGVQLSTTELDKQIKQQARAGMPTGLDDLSFNCTLRNPTTVPYFACNFQELTSSGTAGTGGFIRSDVFRSEDNICGLGTGYASAWTSYPDYYITNISATVQVDGINIDITPLCFGEDRAITSTHGVNKVIAVYNRKANIAGTNQNGTMIHQAPNDGTGFTVSPLHLASFTHPSEAHIQENYGNSGDSLRLTGPTTAITYMLSGDGRTIYKLVLRVSGVITRITAKVRGNSIGYLEYINTVDNNQGITDNGSKFQDFEFRPTITIDAQTPIVLEFSATSNFDLMNLIFIPYYDTPIY
What is the function of this protein?
Binds to the brush border membrane vesicles of scarab larvae and damages the gut wall somehow to allow the vegetative cells of P. popilliae to enter the hemolymph.
What are the official names of this protein?
Parasporal crystal protein Cry18Ba, 76 kDa crystal protein, Crystaline parasporal protoxin, Parasporal delta-endotoxin CryXVIIIB(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: QUEH_BORPE
Sequence: MSQLVRPTLELPAGRRKVLLHSCCAPCSGEVMEAMTASGIDYAIYFYNPNIHPVKEYEIRKNENIRFAEEHGIEFIDADYDMDNWFERVKGMENEPERGIRCTACFDMRFERTALYAHEHGFDTITSSLGISRWKDMNQINGCGERAAARYDDLVYWTYNWRKGGGSQRMIEISKRENFYQQEYCGCVYSLRDTNRHRRAQGRERIHLGVKFYGVEEKL
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase QueH, Queuosine biosynthesis protein QueH.
What is the protein family that this protein belongs to?
Belongs to the QueH family.
Protein: CXA1_HUMAN
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).  May play a role in cell growth inhibition through the regulation of NOV expression and localization.  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
Protein: RIMP_THEPX
Sequence: MSKIEQIAKDLVMPILEKNNFELVDVEYKKEGSHWYLRVYIDKEGGITLDDCQLVSEYLSDRLDEVDPIEHSYILEVSSPGLDRPLKKPRDFERNIGKEIEISLYTPIDKRKKFEGELIEFTGDKIIILYNGERKEFDMKNVSLVKPVIKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.