PharMolix/UniProtQA huggingface dataset:
Protein: RNP4_THESM
Sequence: MSKKFSRRKEQREKKKIALERIDILFNLAERVFAYDKELANRYVEIALAVQQKAKVRMPRKWKRRYCKKCHSFLVPGVNARVRLRQKRMPHVVIKCLECGHIMRYPYLREKKERRKAKKQ
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRF6_ARATH
Sequence: MERRTRRVKFTENRTVTNVAATPSNGSPRLVRITVTDPFATDSSSDDDDNNNVTVVPRVKRYVKEIRFCQGESSSSTAARKGKHKEEESVVVEDDVSTSVKPKKYRGVRQRPWGKFAAEIRDPSSRTRIWLGTFVTAEEAAIAYDRAAIHLKGPKALTNFLTPPTPTPVIDLQTVSACDYGRDSRQSLHSPTSVLRFNVNEETEHEIEAIELSPERKSTVIKEEEESSAGLVFPDPYLLPDLSLAGECFWDTEIAPDLLFLDEETKIQSTLLPNTEVSKQGENETEDFEFGLIDDFESSPWDVDHFFDHHHHSFD
What is the function of this protein?
Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development.  Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor CRF6, Protein CYTOKININ RESPONSE FACTOR 6.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Protein: SPF30_XENTR
Sequence: MAEDLAKQLAGYKAQLQQVESALTANGENEDLLKLKKDLQEVIELTKDLLSSQPSETADDACDDMSASGSQSWKVGEKCMAVWSDDGQWYEAEIEEIDEENGTAAITFAGYGNAEVTSLLNLRPVEEGRKAKEDSGNLPMSKKEMIAAQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNKAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ
What is the function of this protein?
Involved in spliceosome assembly (By similarity).
What are the official names of this protein?
Survival of motor neuron-related-splicing factor 30, Survival motor neuron domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SMN family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.
Protein: SPED_PSEAE
Sequence: MKSKLKLHGFNNLTKTLSFNIYDICYAETPEDLQAYVQYIDEEYDAERLTQILTDVVDIIGANILNIARQDYDPQGASVTILISEQPVTPTDSQIEESPGPLPDTILAHLDKSHITVHTYPEIHPVDGIATFRVDIDVSTCGVISPLKALNYLIHQFDSDIVTVDYRVRGFTRDIEGRKHFIDHEINSIQNYLSDDTREAYQMTDVNVYQENLFHTKMLLKDFELENYLFGDATRTLSAEQREQVTERLKHEMLEIFYARNMPR
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: MIA40_SCHPO
Sequence: MFAKNLLFRFPKCIRINGYNNMRRSLLQRNGFQAGICRKFGTATKTDVWKGRFLPIVSGVAAASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: YQIH_ECOLI
Sequence: MRYLNTKNIIAAGVLLSCMSSIAWGAIIPDRTRIIMNESDKGEALKLTNQSKNLPYLAQTWIEDTKGNKSRDFIVTVPPMVRLNPSEQIQIRMITQEKIAQLPKDRETLFYFNVREIPPKTDKKNVMQVTMQHALKLFWRPKAIELEDDGVMTYEKVEIIRRNDGSIRFNNKMPYHVTLGYIGTNGVTMLPQTQSLMVTPFSYANTQFKNVPSTFQVGYINDFGGLSFYEINCPVVNNICNISVANRDQ
What is the function of this protein?
Could be required for the biogenesis of a putative fimbria.
What are the official names of this protein?
Uncharacterized fimbrial chaperone YqiH.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HPAC_ECOLX
Sequence: MQLDEQRLRFRDAMASLSAAVNIITTEGDAGQCGITATAVCSVTDTPPSLMVCINANSAMNPVFQGNGKLCVNVLNHEQELMARHFAGMTGMAMEERFSLSCWQKGPLAQPVLKGSLASLEGEIRDVQAIGTHLVYLVEIKNIILSAEGHGLIYFKRRFHPVMLEMEAAI
What is the function of this protein?
Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH.  Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion.
What are the official names of this protein?
4-hydroxyphenylacetate 3-monooxygenase reductase component, 4-HPA 3-monooxygenase small component, Flavin:NADH reductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
Protein: MTRA_METKA
Sequence: MPEKAEPAEGWPVVEGDYVVGDPEAPVHVVTLGSHIEEDILKAAGEDKVAIAGPCKTENIGIEKVIANVIANPNIRFGVLCGAEVTGHLTGQCFKAMYENGVDPDSGEIIGAEGAIPYLENIPEEAVERYRDQIVELVDLIDVEDVDEIVKAIEECVEKDPGAYEEGPMTISLEEEEEEELAEVAGMPVSAETVTVEYRINDVRVGVKSIGAMQRYMAGYLSGRTMGLLIGIISGMIFLFLPMVVLGGV
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit A, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A.
What is the protein family that this protein belongs to?
Belongs to the MtrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: LGT_DEIRA
Sequence: MPRRGPFLALFAGCVSRGASRSPPGHTLTRRPMDPVFLQIGNFTIAWYGVLMMLGIAAGYWLGLKLARERGLNADLFERMILWMLFWGFVGARLVFVLTSWHIFEGIPFPRVLLDIVNLRNGGISIHGGLIGGVLTLIYFARRYRLNFYQYADLAVPGVAFGIIGGRLGNIMNGTDTVGRVTGWPIGYHWPASARAFHEGMCRPNPNPDMDLSKYCHEVGGQIMMTAPVHFTQLYGVIIGIILAVASYFWLKSRVPGWAFWQFWLWYSILRAGWEETFRLNPLTIKTYLNQGLDAPGIGLWTDTQIFSVPLILVSLWMLWRLRQRRQVTVPTVPVQSQS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: G6PI_RIPO1
Sequence: MDKLQLWQRYQNWLYYHEGLGIYLDISRMRFDDPFVDRLKPKFDKAFQDMEALEAGAIANPDEGRMVGHYWLRAPELAPNDEARKEITEPLAAIADFVTKVHNTTIKPPTAEKFTDVLSIGIGGSALGPQFVAEALSSDFPPMAIHFIDNSDPAGIDRILTRLGDRLKSTLVIVTSKSGGTPETRNGMLEVKAAYEAKGLDFAPHAVAVTMPGSKMDQFAENWLARFPMQDWVGGRTSELSAVGLLPAALQGIDIQAMLAGAKEMDVATRVKDLKTNPAALLALAWYYSGNGKGEKDMVILPYKDSLLLFSRYLQQLVMESLGKETDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATFIEVLEDRQGESIELDPGITSGDYLSGFIQGTRQALYENNRDSVTITIPQVNPRIVGALIALYERTVSFYGSLVNVNAYHQPGVEAGKKMAASILSLQTEIQKVIKESVGSLDLVTLAEKAGDPEAVEAVYKIVRHLAANGRGVTLDGDLANPSSLKVSAG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RE107_YEAST
Sequence: MVARGRTDEISTDVSEANSEHSLMITETSSPFRSIFSHSGKVANAGALEESDKQILEWAGKLELESMELRENSDKLIKVLNENSKTLCKSLNKFNQLLEQDAATNGNVKTLIKDLASQIENQLDKVSTAMLSKGDEKKTKSDSSYRQVLVEEISRYNSKITRHVTNKQHETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHSLQTRQTALEMAFREKADHAYDRPDVSLNGTTLLHDMDEAHDKQRKKSVPPPRMMVTRSMKRRRSSSPTLSTSQNHNSEDNDDASHRLKRAARTIIPWEELRPDTLESEL
What is the function of this protein?
Essential for meiotic chromosome segregation.  MER1 and MER2 proteins must interact directly or indirectly.  MER1 might be responsible for regulating the MER2 gene and/or gene product.  MER2 is not required for mitosis and mitotic DNA repair mechanisms.  Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
What are the official names of this protein?
Recombination protein 107, Meiotic recombination protein 2.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to chromosomes.
Protein: TM204_MOUSE
Sequence: MTLQKLVATAVLVALVSLILNNAAAFTPNWVYQTLEDGRKRSVGLWKSCWLVDRGKGVTSPGTRTGQVDTHDCEVLGWGSESAGFQESRGTVKLQFDMMRACNLVATAALVVGQITFILGLTGLPLMSPESQCWEEAMAAAFQLASFVLVIGLVTFYRIGPYTNLSWSCYLNIGACLLATLAAAMLIWNILHRREDCMAPRVIVISRSLTARFRRGLDNDYVESPC
What is the function of this protein?
Can influence paracellular permeability.  Appears to be involved in cell-cell interactions through adherens (By similarity).
What are the official names of this protein?
Transmembrane protein 204, Claudin-like protein 24.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Co- localizes with the beta-catenin adherins.
Protein: SURE_BURP6
Sequence: MRILLSNDDGYLAPGLAALYEALRPLAEILVMAPEQNCSGASNSLTLSRPLSVSRSAATGFYYVNGTPTDSVHVALTGMLDTKPDLVVSGINNGQNMGDDTLYSGTVAAATEGIMFGVPAIAFSLVHKEWAHLGDAARVAAEIVRHYLDHPLPGQPLLNVNIPNLPYEELKGWRVTRLGKRHPSQPVIRQTNPRGEPIYWIGAAGDALDASEGTDFHATASGYVSITPLQLDLTHTQMLAATRDWARAGSGAS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_METKA
Sequence: MVRDKWKDKVWYTILAPDMFDNVEVGETPADDPEKVIGRVLETTLGDVLDDITKHHIKVFFRIYDVEGTTAYSKFEGHRLMRDYVRSLVRRGTSRIDGVIDVVTKDGYKVRVAGLAFTTRRAKTSQQRAIRKEMFKVIEENAKECDFDEFIRRCLSISEEESIPEQIKEAGRKIYPIRQAEIRKTEVLEEPNGLPPYEAVGDRATPELASY
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: SIAT2_RAT
Sequence: MKPHLKQWRQRMLFAIFVWGLLFLAIFIYFTNSNPAAPMPSSFSFLESRGLLPVQGKQRVIMGALQEPSLPRSLEPSKVLMDGHSASPFNSWPGDPQKGDQAQDGFDNGDEFFTSQVGRKSQSAFYPEEDNYFFVAGQPGLYHHRQGALGLPSPGESSWQSGPGQPKQEKLRHPRRGSLPEEAYDSDMLSTSMSRAFLYRLWKGTVSSKMLNPRLQKAMRYYMSFNKHGVRFSRRGRREARRTGPELLCEMRKRVRVRTLDGKEAPFSGLGWRPLVPGVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRLKYPTQPFYILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILVMMSMCQEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNTGTQADLHHKGKVVLPGFQTLRCPVTRPNNTNT
What is the function of this protein?
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.  Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
What are the official names of this protein?
Beta-galactoside alpha-2,6-sialyltransferase 2, Alpha 2,6-ST 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2, ST6Gal II, ST6GalII, Sialyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: L_RABVB
Sequence: MMIDPGEVYDDPIDLIESEAEPKGNPTIPNILRNSDYNLNSPLIEDPARLMLEWLKTGNRPLRMTLTDNCSRSHKVLKDYFKRVDLGSLKVGGAAAQSMISLWLYGAHSESNRSRKCINDLAQFYYKSSPIEKLLNCTLGNRGLKTPPEGVLSCLARVDYDKAFGRYLANIYSSYLFFHVITLYMNALDWDEEKTILALWRDITSIDTGKDLVKFKDQIWGLLIVTKDFVYSQSTGCLFDRNYTLMLKDLFLSRFNSLMILLSPPEPRYSDDLISQLCQLYIAGDQVLSMCGNSGYEVIKILEPYVVNSLVQRAEKFRPLIHSLGDFPTFIRDKVGQLEGTFGPSAKRFFKVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHLKKVIDKSYQECLASDLARRILRWGFDKYSKWYLDSRLLSRDHPLIPYIKTQTWPPRHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRGGPVPSEKVIITALSKPPVNPREFLKSIDLGGLPDEDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRVTGQGLLDYSRVTYAFRLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQRSWIYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLRQKGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSREGLLYELESISRNALSIYRAIEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRGNILVPESKRWARVSCISNDQIVNLANTMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGDNFLLAMSRIIYLDPSLGGVSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSNESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDEVENSEFREAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRTLEESFYNSETHGINRMTQTPQRVGRVWPCSSERADLLREISWGRKVVGTTVPHPSEMLGLIPKSSISCTCGAAGGGNPRISVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESINWFITRNSNRAQTLIRNIMSLTGPDFPLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGRNYDFMFQPLMLYAQTWTSELVQKDTRLKDSTFHWHLRCNKCIRPIDDMTLDTSQVFEFPDVSRRISRMVSGAVPHFRKLPDIRLRPGDFESLSGKEKSRHIGSAQGLLYSILVAIHDSGYNDGTIFPVNIYSKVSPRDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKVPAAYPTTMKEGNRSILCYLQHVLRYEREAITASPENDWLWIFSDFRSSKMTYLTLITYQSHLLLQRVDKNLSKSMRANLRQMSSLMRQVLGGHGEDTLESDEDIQRLLKDSLRRTRWVDQEVRHAARTMTGSYSPHRRVSRKAGCSEWVCSAQQVAVSTSANPAPASELDIRTLSRRLQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSLCLVVGDGSGGISRAVLNMFPDARLVFNSLLEVNDLMASGTHPLPPSAIMSGGDDIISRVIDFDSIWEKPSDLRNLTTWRYFQSVQEQVNMSYDLIICDAEVTDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPDYRAIQHLSRAFPAVTGFITQMTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFNCSSPKSEMQRARSLNYQDLVRGFPDEVISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVSIIIAIMIVFSNRVFNVSKPLTDPLFYPPFDPKILRHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNIYLSWSWSDDTSVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGSIEDLSGEIEKHLRGYNRWITLDDIRSRSSLLDYSCL
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
Large structural protein, Protein L, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviruses protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: ASTB_SHEAM
Sequence: MKHFEANFDGLVGPTHNYAGLSFGNVASQSNAAQVSNPKDAAKQGLKKAKALADMGMVQGMLAPQERPDIHTLRRVGFTGSDADVLSQAAKASPVLLQACASASSMWTANAATVSPSADSDDGKLHFTPANLVDKLHRSIEPVTTGNILKAIFTDERYFAHHQHLPEHPHFGDEGAANHTRLCHDYGQAGVEVFVYGRSVADLSRPAPVKYPARQTLEASQAVARLHQLSDDRTVYMQQNPDVIDQGVFHNDVIAVGNQNVLFYHEQAFLETQAKLAEIDKKMHGNMYFIEVPTAKVSVQDAVKSYLFNTQIITLSDGNMAIIAPTDCQENPAVHAYLNELVTLNTPIKAVHYFDVKQSMQNGGGPACLRLRVAMNETELAAVNPQVMMNDALFARLNQWVDKHYRDRLSTQDLADPQLLMESRTALDELTQIMKLGSVYQFQR
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: PYRG_BURP1
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVISVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVGKYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRRGTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPNTPERVVALITEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRFVPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQAALACQQTRAGAKA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: DEF1_CANAW
Sequence: MSTYRKTYKNQSKRFNNGNNSNSTSTELTNLVEMFPDWEADELQGLLSENDNSLEIVIDLIVNNKVSKWEPIKKEKHKKKEHKDDTTDSVTGNANGASNSGSSNSTTASGDRRLNNKAKASTSSRPPKRQQHPNAAHKKNEKTERSKASTVSTTTTSATSSVTKESVPPSNSWAAALSNDKPKKQETKSEASESIPSSNDGGDAETVPEVEQAETLEESHQEPENVEEPIESVSEQSQPENTKPVLKSAAIPEPKQGSWASAIAPKTKPKPKTVSKPVPQPEESKPEEHIPVQEEAQPVESVLEDKPAVEAVQPVQPPVEDEPVEAPAASSVAAVADASFSEPTASSIIDQQPQVVLPTTQQQVDSVGISFGSLSVDAGEPKEAAEVIQDETISEQVQPEQQQQSQQQPLQEQQRYGLYNQQPTQQRYQQNNYQQQGQYSKQQQQQLQQQNTSQPTQQQTTIRLLWSISTTTISSTNSSTRCSIWWLSWILL
What is the function of this protein?
Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II.  Also involved in telomere length regulation.  Binds DNA.
What are the official names of this protein?
RNA polymerase II degradation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: NANA_STAA3
Sequence: MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_PSYIN
Sequence: MDLKKLSGSELLIELEKLNCDLAIPWKIEDEKLSKTFKFKNFMQAFAFMTQSALYAEKKNHHPEWFNIYNKVVIQLTTHDVAGISFKDFDLAKKMESFIPHF
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: NDUA4_HUMAN
Sequence: MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPNDQYKFYSVNVDYSKLKKERPDF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:22902835).  NDUFA4 is required for complex IV maintenance (PubMed:22902835).
What are the official names of this protein?
Cytochrome c oxidase subunit NDUFA4, Complex I-MLRQ, CI-MLRQ, NADH-ubiquinone oxidoreductase MLRQ subunit.
What is the protein family that this protein belongs to?
Belongs to the complex IV NDUFA4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RS9_RHOPS
Sequence: MSETMQSLDQLSALKTTQPDAPTYTKKVDKQGRAYATGKRKDAVARVWIKPGAGKVTVNAREVEVYFARPVLRMMIQQPLVAAARAGQYDVICTVAGGGLSGQAGAVRHGISKALTNFEPELRGVLKKGGFLTRDSRVVERKKYGKAKARRSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: IXTPA_ACIB5
Sequence: MSTPHWFDQGSLVLASNNKGKVAEFEKLFEQLKLPVEIIPQGRLNIPDAIEDGLSFIENAIIKARHASKISGKPAMADDSGICVPVLGGAPGIYSARYAGEHGDDAANNAKLLNDLLPFRKNGEAIEGMFVCVLALVTHAEDPLPQIFQGIWHGEILEAPRGENGFGYDPLFWLPELQVSSAELSKEDKNKISHRGQAMQLFRESLQK
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: Y3042_BORPD
Sequence: MSHSAGPGAAQPATAAAPRQRTPWITRVGRVFRFAAQRADEEKLLQVASSLTFTTVLGIVPMLAVVLSLFTAFPVFQDFRLALEDFLANSLMPPAVSDNIMDYLNQFAYQASRLTAIGGAFLVVTSLLLIMTIDKTFNDIWHVTRQRPLPQRALVYWAVVTLGPVVAGASLWATSFLARESLGLVRDVPEIVSLAISFLPLILTGLGFAALFVVVPNRHVYWRDALVGGFGTAIVLELMKAAFAYYLTRFPTYTVIYGAFATLPIFLLWIYLSWLAVLFGATVAASAPLIRLGRWEINRSPGAPFIDALAVLRALHAAQGMRPAGRSASALAKRLHLHHDELNAVLEKLENLGLAARTAEQRWILACDPRSTTLEPVFDNFLLDRHQPRLRDDPQVVQAAAAVLGQDGGQAPTLEELAGLAHNTPVGLAAIVPLEAGKNSRRGPHAPGESSC
What are the official names of this protein?
UPF0761 membrane protein Bpet3042.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.