PharMolix/UniProtQA huggingface dataset:
Protein: PSBE_THAPS
Sequence: MSGGSTGERPFSDIITSVRYWIIHTITIPSLFVSGWLFISTGLAYDVFGTPRPNEYFTQDRQQVPLVNDRFSAKQELEDLTKGL
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VIF_HV112
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: HIS6_NEIMB
Sequence: MALAKRIIPCLDVKDGRVVKGVNFIGLRDAGDPVEAAKRYNGEGADELTFLDITASSDNRDTILHIIEEVAGQVFIPLTVGGGVRTVADIRRLLNAGADKVSINTAAVTRPDLIDEAAGFFGSQAIVAAVDAKAANPENTRWEIFTHGGRNPTGLDAVEWAVEMQKRGAGEILLTGMDRDGTKQGFNLPLTRAVAEAVDIPVIASGGVGNVRHLIEGITEGKADAVLAAGIFHFGEIAIREAKRAMREAGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_STRZJ
Sequence: MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSIGGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIRLTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: LDH1_PERPY
Sequence: MKQRNVNRVALIGAGSVGSSYAFALLNQSITEELVIIDLNENKAMGDAMDLNHGKVFAPNPTKTWYGTYSDCKDADIVCICAGANQKPGETRLDLVEKNLRIFKGIVEEIMASGFDGIFLIATNPVDILTYATWKFSGLPKERIIGSGTILDTGRFRFLLGEYFDIAPANVHAYIIGEHGDTELPVWSHADIGGISITELIKRNPEYTMKDLDELFINVRDAAYQIIEKKGATFYGIAMGLARITKAILNNENSVLTVSTYLDGEYGTEDVYMGVPAVVNRNGIREIVELTLNEQERQQFKHSANVLKEILAPNFKEQ
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1, L-lactate dehydrogenase P, L-LDH P.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL361_PSEA7
Sequence: MKVRASVKKLCRNCKIIRRDGIVRVICSAEPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: ELP3_MOUSE
Sequence: MRQKRKGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKMKTKTAAKYGLASQPRLVDIIAAVPPHYRKILIPKLKAKPVRTASGIAVVAVMCKPHRCPHISFTGNICIYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRSLHDALSGHTSNNIHEAIKYSERSFTKCVGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAACESFHLAKDSGFKVVTHMMPDLPNVGLERDIEQFIEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKMAVISGVGTRNYYRKIGYRLQGPYMVKMLK
What is the function of this protein?
Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).  May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (By similarity).  Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337).  Required for acetylation of GJA1 in the developing cerebral cortex (PubMed:28507509).
What are the official names of this protein?
Elongator complex protein 3, tRNA uridine(34) acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ELP3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LAC1_ARATH
Sequence: MENLGFLIISTFLLLFTTLLPYSSASTTRRFHFNVEWKKVTRLCHTKQLLTVNGQYPGPTVAVHEGDIVEIKVTNRIAHNTTIHWHGLRQYRTGWADGPAYITQCPIRSKQSYTYRFKVEDQRGTLLWHAHHSWQRASVYGAFIIYPRQPYPFSGSHIQSEIPIILGEWWNDDVDNVEKAMMKTGAGAKVSDAYTLNGLPGPLYPCSTKDTFTATVDAGKTYILRIINAALNNELFVAVANHTLTVVEVDAVYTKPVHTKAIMIAPGQTTTLLLRADQLSGGEFLIAATPYVTSVFPFNNSTTVGFIRYTGKTKPENSVNTRRRRRLTAMSTVVALPNMLDTKFATKFSDSIKSLGSAKYPCKVPTKIDKRVITTISLNLQDCPLNQTCDGYAGKRFFASMNNISFVRPPISILESYYKKQSKGVFSLDFPEKPPNRFDFTGVDPVSENMNTEFGTKLFEVEFGSRLEIVFQGTSFLNIENHPLHVHGHNFFVVGRGFGNFDPEKDPKRYNLVDPPERNTFAVPTGGWAAIRINADNPGVWFIHCHLEQHTSWGLAMGFIVKDGPLPSQTLLPPPHDLPQC
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Laccase-1, Benzenediol:oxygen oxidoreductase 1, Diphenol oxidase 1, Urishiol oxidase 1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: XPT_DEIRA
Sequence: MQSLVEAIKREGRVLPGGFLKVDGLVNHQLHPALTREMGETFARHFAPLAPTKVLTIEVSGIAPAIMTAAELGVPMVYARKKKPLTMSEQVYTAQSVSRTKGGTVDLFVSSEYLGPQDRVVVIDDFLASGGTLRSLSQIIADSGATLLGLGCVIEKEFEGGRQHLADLNVPIHTLANIVRMSEEEGIVVQAGR
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_SACSH
Sequence: MPDIVNRKVEHVEIAAFENVDGLSSSTFLNDVILVHQGFPGISFSEINTKTKFFRKEISVPVMVTGMTGGRNELGRINKIIAEVAEKFGIPMGVGSQRVAIEKAEARESFAIVRKVAPTIPIIANLGMPQLVKGYGLKEFQDAIQMIEADAIAVHLNPAQEVFQPEGEPEYQIYALEKLRDISKELSVPIIVKESGNGISMETAKLLYSYGIKNFDTSGQGGTNWIAIEMIRDIRRGNWKAESAKNFLDWGVPTAASIMEVRYSVPDSFLVGSGGIRSGLDAAKAIALGADIAGMALPVLKSAIEGKESLEQFFRKIIFELKAAMMLTGSKDVDALKKTSIVILGKLKEWAEYRGINLSIYEKVRKRE
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXAC_SALTY
Sequence: MATFMTEDFLLKNDIARTLYHKYAAPMPIYDFHCHLSPQEIADDRRFDNLGQIWLEGDHYKWRALRSAGVDESLITGKETSDYEKYMAWANTVPKTLGNPLYHWTHLELRRPFGITGTLFGPDTAESIWTQCNEKLATPAFSARGIMQQMNVRMVGTTDDPIDSLEYHRQIAADDSIDIEVAPSWRPDKVFKIELDGFVDYLRKLEAAADVSITRFDDLRQALTRRLDHFAACGCRASDHGIETLRFAPVPDDAQLDAILGKRLAGETLSELEIAQFTTAVLVWLGRQYAARGWVMQLHIGAIRNNNTRMFRLLGPDTGFDSIGDNNISWALSRLLDSMDVTNELPKTILYCLNPRDNEVLATMIGNFQGPGIAGKVQFGSGWWFNDQKDGMLRQLEQLSQMGLLSQFVGMLTDSRSFLSYTRHEYFRRILCNLLGQWAQDGEIPDDEAMLSRMVQDICFNNAQRYFTIK
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: TRUD_HISS2
Sequence: MNELAYLQTMPKQTALLKTHCADFVVKEQLGYEMSGDGEFVAVKVRKTDCNTLFVAEKLAHFAGIPAKNMGYAGLKDRKAITEQWFCLQMPGQPTPDFNQFQLDGVEILEVTRHNRKIRTGSLDGNHFEILLREAQEDADLKVRLENIKKNGFPNYFTEQRFGRDGHNLTQALRWAKGEINVKDRKKRSFYLSAARSEIFNLIVSARIRQGLHHKILVNDILQLSGSHSWFHADQKEDFNLLQQRLAQQDIQITAPLIGENVQIASDVENEIIAKHQELLYLMHQEKMKSARRPILMQAQHLSWSFIPEGLKLTFYLPAGSYATALVRELVNINE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: CHK1_ENCCU
Sequence: MPKYELQETLASGSTSKVKRAAAPGNAKCVVKVIRKKDVPLRVFLREVKIHRSLRHPNIVGFVDSYEDCHGYCIVMKLGCGEVGSMIRAGGGLDPLLAHFYFRQLVSAVEYLHGKCICHRDIKPENMLIDSAGNLLLSDFGFSTVFFHKGRRRRLRSPAGSLEYMAPEVFEGAYDGELADVWSCGVSLVVFLTGALPWDRAVESDERFSAFVSSRGGCQVPLSSIGDQAMGLVMRMTAKEDRRPSVSTVMKDPWVMQPNELLDESGLCRDSCRLFSLVPRQTGSALHFTQPGEVHKTPRTRPVSSQPRRAGSGDICRVYIGEESLRLALRRVCEALDGMVVSHRIAKEHVMFSTVDSRRSVLSGEVGVIRLDEGCCMTIRRAKGDPQEFKRFTRVLAESLGCNGRKCTILYNEI
What is the function of this protein?
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA.  May also negatively regulate cell cycle progression during unperturbed cell cycles (By similarity).
What are the official names of this protein?
Probable serine/threonine-protein kinase CHK1 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDK_PSYIN
Sequence: MPLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFYQPLIDFMTSGPMVVQVLQAENAINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSDSPASAAKEIAFFFSDDEICPPAAD
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4P1_MACFA
Sequence: MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity).  Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).  Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity).  Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity).  May play a role in the regulation of cellular cholesterol metabolism (By similarity).
What are the official names of this protein?
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 1 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: TLP12_ORYSJ
Sequence: MSFRSIVRDVRDSFGSLSRRSFEVRISGLPGLSGHHRGKSLGSLSELRDRPVVVDQSRWVGLPPELLRDVMKRLEEGESNWPSRKDVVACAAVCRTWREICKDIVQSPEICGKLTFPVSLKQPGPRDGLIQCFIKRDKSKLTYYLYLCLSPAVLSENGKFLLAAKRNRRATSTEYIISVDSKNISRSSNGYVGKMRSNFLGTKFVVYDTQPPYNAGSLMSCQHGSRRISSRRVSPKLPTGSYPIAHVKYELNVLGTRGPRRMQCTMHSIPASAVDPEGVVPGQPEQLLPGPFEESFRSTNTSSRFSFMDRSLDFSSSRFSEISGSANQQGEDDIPEAKERPLVLRNKVPRWHEQLQCWCLNFRGRVTVASVKNFQLIAAASSESSQLEQQQQQQQQNHASSSSSASDHGKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLTSFDTKLACE
What are the official names of this protein?
Tubby-like F-box protein 12, OsTLP12, Tubby-like F-box protein 2, OsTLP2.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
Protein: UREE_STAAN
Sequence: MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYGDILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVEDLLKSLGIPYVREDRKVNKAFRHIGHSHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_LIGS1
Sequence: MKMIEKYRGKKVLVLGLGKSGVNAAKLLKKLGAEVTVNDKNTPSDLTQVNELKNEGIEVITGSHPLELLENIDLMVKNPGIPYTNVLVSGAKDKGIKIITEPELAFEISDARFVGVTGTNGKTTTTTMISLMLNQGQTEGKAYVAGNIGVPASQVAQEATSKDTIVTELSSFQLLGITEYHPKVAVLTNIYEAHIDYHGTRENYVNAKMRIVMNQTEDDYFVVNWDNEEWQELSQRSKAKIVPFSRLGKSKDGAYVAGGYLFYKEDKIMPVDNIKVPGTHNVENALAAIAVAKIFGKSNEDIKEVLTTFSGVRHRTQYVTTLNGRKFYNDSKATNMEATEKALAGFNNPVVLLAGGLDRGFTFEKLEPSLKNKVHAMIVFGETADLMAKAGKEAGVEKIIKTKDAVSAVPEAYKVSNEGDVILLSPACASWDQWPTFEVRGDKFIEAVEKLTEELEEK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_SULIN
Sequence: MRLRHVVSSLDLTRDDYFRIFELADKFSNVKKLNYLSGKVVSLAFFEPSTRTAQSFHTAAIKLGADVIGFASEESTSIAKGENLADTIRMLNNYSNCIVMRHKFDGAALFASEISDIPIINAGDGKHEHPTQALIDLYTIYKVFGEIDGRTFGLLGDLKYARTVNSLLRALTRFKPKKVFLISPSQLKVRREILDGLNYPVIETENPYDVIQDIDVLYVTRIQKERFVDEVEYEKVKESYVVDLKLVNMMKKDGIILHPLPRVTEIDRKVDKTTNAKYFYQASLAVPVRMALFYEVLGERKDD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: NP04_HHV11
Sequence: MSNPQTTIAYSLCHARASLTSALPDAAQVVHVFEYGTRAIMVRGRERQDRLPRGGVVIQHTPIGLLVIIDCRAEFCAYRFIGRDSNQKLERGWDAHMYAYPFDSWVSSSRGESARSATAGILTVVWTADTIYITATIYGSPPEETPGAAHGVGAAPPPPTTACPGTAEFLQPTADLLVEVLREIQLSPALEYADKLLGS
What are the official names of this protein?
Nuclear protein UL4.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL4 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ABCA2_ASPFU
Sequence: MAMQPSYPAPFGAAAISSSAGQEVASTIRRQFTDADADRIVETPLGEKADSSDTAGPDSEDGIDQEGHDKITALARSLSQISQKSAGPTNTFLDPSSDPELDPNSDKFSSRKWMKNLLHIKTRDPDRYPRRTAGVSFRNLNAYGYGTAADYQADVANMWLKGFGWLRSILGCRNRVQIDILRNFEGFVRSGEMLVVLGRPGSGCSTFLKTIAGETHGLWLDEGTHIQYEGISWDEMHSRFRGEVIYQAETEIHFPQLTAGETLLFAAQARTPANRFPGVSREQYATHMRDVVMTMLGLSHTVNTRIGNEYIRGVSGGERKRVSIAETILCGCPLQCWDNSTRGLDSSTALEFVKNLRLSTDYTGSTAIVAIYQASQAIYDIFDKVIVLYEGRQIYFGKASDAKRFFIDMGFDCPDRQTTGDFLTSLTSPSERLVRKGYEALVPRTPDEFAARWRESAERQRLLADIEAFENESPLGGSKYKEFTVSRAAEKAKGTRAPSPYTLSYPMQIRLCLRRGFLRLKGDMSMTLATVIGNSIMAFIVSSVFYNLDQTTNSFFSRGALLFFAILLNAFASSLEILTLWQQRPIVEKHDKYALYHPSAEAISSMIVDLPSKFLVSVVFNLILYFMTNLRRTPGHFFVFYLFSVTITLTMSNIFRWIGAISRSMAQAMVPSSIFMMILVIYTGFTIPVRDMHPWFKWLNYLNPIGYAFESLMINEFSDRRFPCAQYVPAGPGYEDVPLSSKICSQKGAVAGQDYVDGDAFINTSYRYFSSHLWRNYGIILGFFFFFLAAYIICSELVRAKPSKGEILVFPRGKIPAFVKKSRRDGDLEGAPTFEKQQLDNAGHDSTAAIVKQTSIFHWQDVCYDIKVKGETRRILDHIDGWVKPGTLTALMGVTGAGKTSLLDVLANRVTMGVITGEMLVDGRMRDDSFQRKTGYVQQQDLHLETSTVREALIFSATLRQPASTPHKEKLAYVEEVIKMLNMEEYAEAVVGVLGEGLNVEQRKRLTIGVELAAKPALLCFFDEPTSGLDSQTAWSICTLMRKLADHGQAILCTIHQPSAILMQQFDRLLFLAKGGKTVYFGELGPNMETLIKYFENKGSSKCPKNANPAEWMLEVIGAAPGSHADQDWPEVWNNSPERAQVRAELARMKEELLQRPPPPRTKEYGEFAMPLWAQFLVCLQRMFQQYWRSPSYIYSKAATSIIPPLFIGFTFWREPTSLQGLQNQMFAIFMLLVIFPNLVQQMMPYFVTQRALYEVRERPSKAYSWKAFMLASILVELPWNILMAVPAYFCWYYPIGLYRNAYPTDSVTERGGTMFLLILIFMMFTSTFSSMIIAGIEQPETGGNIAQLLFSLCLIFNGVLASPSALPGFWIFMYRVSPFTYLVSAVLSVGLAGTSVKCSDIEILHVPPPQGQNCSSFLDAYVQMSHGRLLNPEATSDCQVCPVADTDTFLAQVSISYSDRWRNVGLLFVYIVFNIFAAIFLYWLIRVPKKRSRKIKEE
What is the function of this protein?
Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole.
What are the official names of this protein?
ABC multidrug transporter A-2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATP6_ASHGO
Sequence: MYLNNNNNMKYYINSPLEQFEIRDLLGLTSPMMDFSFINITNFGLYTMITLLVILTMNLMTNNYNKLVGSNWYLSQEMIYDTIMNMVKTQIGGKVWGYYFPLVYTFFITIFTMNLISMIPYSFAMTSHVVFVVSMSMIIWLGTTIIGFYTHGLKFFGLFLPTGTPLILVPLLVSIELLSYFARTISLGLRLSANIMAGHLLIVILGGLLFNLMAMNILTFLLGFLPMIAILGIVCLEFAITIIQAYVWCILMSSYLKDTIYLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CRTC3_XENLA
Sequence: MTATPANSGSNPRKFSEKIALHNQKQAEETRAFDELMSDLTVSRVQFQKLQQLRLAQTRAQYYGGSLPNVNQISSSPNDFQPSFHPMDNIRGMRHHGLVERVSRNRLHSSHHRPVEKHGRQCDSSPYGSVYLSPPPDNNWRRTNSDSALHTSASSSKLQDAFMGGNQAMLRAPKPPQRNPSLQDGEMNNFGEAFSYPTSMTEENMLNVTKPLPKQIWEAQKVQCITSRPRSCEVPGIKVFPSSDSNASLSHYQGSLNTGGSLPDLTNLHFPSPLPTPLDPDDTVYANINAENSSGLPAAMTHLGISNSQGIQNTCSNPSIQATMNNNVNNHTPPGRNNPTLHPSLRLSSLSNPSLPTSALGSSPRRRHTPVSPLTLTPGSESNRSISNQFSPTSPMDMLPNSQGVSMDRCPLSLPPLEPPPPYPLYTDQPQPQLHHTQQQMHESPESQNFQPPSPVPCPPLDLNLANSSLSGFFGDSFFDQQQPTKQGKYLWQQQEQYDMFGSPSSSLPNTNAFFDPNMNLQYSQASLMGLGGSHGSLQDSFHLRPNYLYSNYGGSVPNIILTDDSSNSLSKDISNAVAGVSELGFDADNTFQFDDELKLGPLSLDGLSMLSDPDMVLPDPSIEDSFRSDKL
What is the function of this protein?
Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.  Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation.  Enhances the interaction of creb1 with taf4.  Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.  Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity).
What are the official names of this protein?
CREB-regulated transcription coactivator 3, Transducer of regulated cAMP response element-binding protein 3, TORC-3, Transducer of CREB protein 3.
What is the protein family that this protein belongs to?
Belongs to the TORC family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.