PharMolix/UniProtQA huggingface dataset:
Protein: PFDA_PYRCJ
Sequence: MSLSRQDIQRLLEEYQLLNDLLASLQAQHATVSELVEELSTALDGVRLLKSEGGERLVHIGAGIFVGGVFEGREVLTPLGAGYYAFLDLENAERIVKERLEEYSKVKTSLEENIEKLTERALQIRQVLERLGLR
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha, GimC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_BACTN
Sequence: MSKKALLMILDGWGLGDQKKDDVIFNTPTPYWDYLMNNYPHSQLQASGENVGLPDGQMGNSEVGHLNIGAGRVVYQDLVKINRACADNSILQNPEIVSAFSYAKENGKSVHFMGLTSNGGVHSSMVHLFKLCDISKEYGIDNTFIHCFMDGRDTDPKSGKGFIEELSAHCEKSAGKIASIIGRYYAMDRDKRWERVKEAYDLLVNGQGKKATDMVQAMQESYDEGVTDEFIKPIVNANCDGTIKEGDVVIFFNYRNDRAKELTVVLTQQDMPEAGMHTIPGLQYYCMTPYDASFKGVHILFDKENVANTLGEYIASKGLNQLHIAETEKYAHVTFFFNGGRETPFDNEDRILVPSPKVATYDLKPEMSAYEVKDKLVDAINENKYDFIVVNFANGDMVGHTGIYEAIEKAVVAVDACVKDVIEAAKAQDYEAIIIADHGNADRALNEDGTPNTAHSLNPVPCVYVTGNKAAKVEDGRLADVAPTILKIMGLEAPADMNGQILIK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: ETR1_SOLLC
Sequence: MGSLLRMNRLLSSIVESCNCIIDPQLPADDLLMKYQYISDFFIALAYFSIPVELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFNMHTRNVAIVMTTPKALTALVSCITALMLVHIIPDLLSVKTRELFLKKKAAQLDREMGIIRTQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLALEECALWMPTRTGLELQLSYTLRHQNPVGLTVPIQLPVINQVFGTNHVVKISPNSPVARLRPAGKYMPGEVVAVRVPLLHLSNFQINDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRARDLLMEQNVALDLARREAEMAVRARNDFLAVMNHEMRTPMHAIIALSSLLQETDLTPEQRLMVETILKSSNLLATLINDVLDLSRLEDGSLQLDIGTFNLHALFREVHSLIKPIASVKKLFVTLSLSSDLPEYVIGDEKRLMQILLNVVGNAVKFSKEGNVSISAFVAKSDSLRDPRAPEFFAVPSENHFYLRVQIKDTGIGITPQDIPNLFSKFTQSQALATTNSGGTGLGLAICKRFVNLMEGHIWIESEGLGKGSTAIFIIKLGIPGRANESKLPFVTKLPANHTQMSFQGLKVLVMDENGVSRMVTKGLLTHLGCDVTTVGSRDECLRVVTHEHKVVIMDVSMQGIDCYEVAVVIHERFGKRHGRPLIVALTGNTDRVTKENCMRVGMDGVILKPVSVYKMRSVLSELLEHGVVLES
What is the function of this protein?
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
What are the official names of this protein?
Ethylene receptor 1, LeETR1.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LISC_ARATH
Sequence: MMHHCSITKPTFSISISTQKLHHHSSKFLNLGFRIRCESGDVSSPLRTKAVSLSSEMEDSSSLKKSLMELEGKKSEPYPGGMPKMGPFTGRDPNVKKPAWLRQKAPQGERFQEVKESLSRLNLNTVCEEAQCPNIGECWNGGGDGVATATIMVLGDTCTRGCRFCAVKTSRNPPPPDPMEPENTAKAIASWGVDYIVITSVDRDDIPDGGSGHFAQTVKAMKRHKPDIMIECLTSDFRGDLEAVDTLVHSGLDVFAHNVETVKRLQRLVRDPRAGYEQSMSVLKHAKISKPGMITKTSIMLGLGETDEELKEAMADLRAIDVDILTLGQYLQPTPLHLTVKEYVTPEKFDFWKTYGESIGFRYVASGPLVRSSYRAGELFVKTMVKESYSKSLS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (PubMed:12062419) (By similarity).  Together with LIP2P and LIP2P2 is essential for de novo plastidial protein lipoylation during seed development (PubMed:23581459).
What are the official names of this protein?
Lipoyl synthase, chloroplastic, Lipoate synthase, LS, Lip-syn, Lipoate synthase, plastidial, LIP1p, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IGW2_HETFR
Sequence: VISGFYPDSVQVSWKKDRVDQSGVVLHSKQRNDSTFETVSYLTVPVVEWTTGDVYTCEVSHTGSRFNDRISMRYQKGGTVNLPVPGGNTPCTCPPSSCSGCMPKLVYQTDLNVTLENGGQLQYNCHQQACKIK
What are the official names of this protein?
IgW chain C region, secreted form 2.
What are the subcellular locations of this protein?
Secreted.
Protein: ECFA1_STAA3
Sequence: MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPYDEMHRRVSEALKQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTATEIFDNAEELTRIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS9_CLOBB
Sequence: MAKVQYMGTGRRKKSVARVRLVPGNGKVVINKREIETFFGLETLRVIVNQPLVLTGTKDKFDVLVNVHGGGFTGQAGAIRHGITRALVKSDETLRPELKKAGFLTRDPRMKERKKYGLKKARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MIAA_CHLTE
Sequence: MNTKPVLVILGPTASGKTELAFRIARQTGGEIISADSRQIYRGMDIGTAKPPRWMLDEVKHHFIDKKEIGEPFSAGDFAEQAAEKIRELHQRGITPVVAGGSTLYLEGLLKGFAELPPADPEIRAQLTRELERHGAEALYRRLEALDPEQAKTLDPTKTQRLIRSLEIIEISGTTVTALQSKTPGPPTGINFTVIGLDLPRELLYERINQRTSAMIQAGLEAEARYLFDKFRDEWRSKNLNALATVGYRELFEHFEELHDLDTAVSLIAQHTRNYAKRQLTFFRNRLDVEWVKAPLDEAEIEALVEFFSTRQDDSVPHSPIAIAKKQNA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PRMA_DESAL
Sequence: MQWMEIKIVFDAAEPELAQEMVSYLVMEHGAEGLEMTTPGETGMVQDGSGSSVPDSKEHSVTAFLPLDDLFEGRKADLTRALDDLKGSVLTDYSVHFSKQDDQPWETAWKAHFHPIEIGESLVIKPSWEDYENPEKRMLIELDPGMAFGTGTHPTTAVCLEMIETECLKKAPERFLDVGTGSGILMIGAYKLGARKVFGCDNDMDALEAAAKNLKGNQVHEGDFGLWLGDLLAGIVEGAFDMVAANITAEANVMLIPGLPRIMAPGSIFIASGIMAEKKDLVLEALDACRFSVERVQETGGWVGIAARMP
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGTL1_BRUO2
Sequence: MSLEGIGFGYRERAPYASNPAFSRGRLVPEPESPTRTPFQRDRDRIIHSTAFRRLKHKTQVFIAHEGDHYRTRLTHTIEVAQIARALARALRLDEDLAEAVALVHDFGHTPFGHTGEDALNERMENFGGFDHNAQSLRIVTKLEHRYADFDGLNLSWETLEGLVKHNGPLLGPYAAHPDIPVPQPILDFNARYDLELSRFASLEAQCAAIADDIAYNAHDIDDGLRAGLLTLESLDEVPLAKRLLDIVRTRYPNLDPVRTGHELVRRQITIMVEDVIEEAQRRLASARPGTMEDVHNQPRALVGFSDAMRAEEKVLKRFLFKNLYFHESVVVRRHAADRIVQDLFDACFTDPSLMPDEWRLGCEALDKAALARRVADYLAGMTDNYAVREHRRLFDRTPDLA
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: RLMN_YERPS
Sequence: MSEQLLTASTPIDAAPLSDNTVQTTAPATSKINLLDLNRQQMREFFAEMGEKPFRADQVMKWMYHYCYDDFEQMTDINKGLRAKLQRVAEIRAPEVAEEQRSVDGTIKWAIKVGDQQVETVYIPEADRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIIGSLKSTGTRPITNVVMMGMGEPLLNLNNVVPAMDIMMDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPTDDIRDEIVPINRKYNIETFLAAVRRYLDKSKANGGRVTVEYVMLDHINDSTEQAHQLAECLKDTPCKINLIPWNPFPGAPYGRSSNSRVDRFSKVLMEYGFTTIVRKTRGDDIDAACGQLAGEVIDRTKRTLKKKMAGEPIAIKTV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHB_MYCLB
Sequence: MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVQVVTCTLGEEGEVIGDRWAELTVDHADQLGGYRIFELTEALRALGVSAPIYLGGAGRWRDSGMRGTAPRRRQRFIDADENEAVGALVAIIRELRPHVVVTYDPHGGYGHPDHVHTHFITAAAVASSGVAAGLEVGADEYPGKPWKVPKFYWSVFALSAFEAGMNALQGKDLRPEWTIPPREEFYFGYSDKDIDAVVEATSDVWAAKTAALTAHATQVVVGPTGRACALSNNMVMPIFAQEHYVLAAGSAGNRDERGWETDLLAGLCLDGFDAR
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: Y2859_ENTFA
Sequence: MPFVHVELIEGRTEEQLTNMVKDITEAVSKNAGAPKENIHVIVNELKKDRYAQGGEWKK
What are the official names of this protein?
Probable tautomerase EF_2859.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: SYFA_METRJ
Sequence: MTDLDTLERDLLAQVGAASDEAALDAVRVAALGKKGSVSDLLKTLGSMTPEERKERGPLINGLRDRVQGAVTARKTELAEAALEARLASERVDVTLPVREAPEVRGRIHPISQVIDEITAIFADMGFAVAEGPDIETDELNFTALNFPPGHPAREMHDTFFLAPDRDGKRKVLRTHTSPVQVRTMRAQTPPIRVIIPGRTYRHDSDQTHTPMFHQVEGLVIDTSANIANLKWVLEEFCKAFFEVDGVKMRFRPSFFPFTEPSAEVDIQCSRKGGEIRFGEGDDWLEILGCGMVHPNVLRNCGLDPDAVQGFAFGVGIDRIAMLKYGMPDLRPFFEADVRWLDHYGFRPLDVPSLVGGLTA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOOK_BRAFL
Sequence: MDKTELCECLVQWLQTFNLNAPHKTVEDLGDGVAMSEALCQIAPDYFSESWFGKIKQDAGENWRLRMSNLKKVLTGVLDYYSEVLGQQINDFTLPDVTSIAENYDVEEMGRLLQLILGCAVNCDRKQEYIQNIMGMEEAVQHAVMNAIQELMNKEAPASPGVLPEVEKQLRDTMEELNEVRAAKEEIAQRCHELDMQVQQLMEENTLMKVEKDELSDKVNQVDGYEDTSTPAGRRYIQLTHQVEQLQEETYRLETGRDEYRLKCEEMEKEILDLAGKNEELMALAAETQLLKDEMDILRQSAEKTSKYEQTIETYKKKLEDLADLRRTVEQLQEETYRLETGLSHCELRKANTLRSQLDMYKKQVQELHGKVSEETKRADKAEFELKRSTEKLDTVQKEKQRIVNERDTLKETNEELHCMQLQQGKAMLYSTGSLAGIGSNVESPVGSPIPEVVPPEIKEKLIRLQHENKMLKLKAEGSDDERLAVSQAMLDDAQARTNELETENRLANQRILELQGQLEDMQTEQEEVGSPAKDQDSVALRKKLEEHMEKLKDADSQLQKKKEYIDNLEPKVSSSAEKIQQLQEMLNKKDDDMKAMEERYKRYLEKAKSVIRTLDPKQNQSSTPEVQALKNQLTEKERLIDHLERDHEKAKLTREQEEKLIVSAWYNMGAQLHRKAVEGRLANGGPMQGGQSFLARQRQATSRRTTVSTTHPGHARSVNFVN
What is the function of this protein?
May function to promote vesicle trafficking and/or fusion.  May act to link a number of membrane-bound organelles to the cytoskeleton (By similarity).
What are the official names of this protein?
Protein Hook homolog.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MTNN_PROMH
Sequence: MRVGVIGAMEQEVKLLREQIENCEIVSRGGCEIYTGKINGVDVALLKSGIGKVAAAIGTTLLLEHFRPDVVINTGSAGGLDAKLNVGDIVVSTEVRYHDADVTAFGYEPGQMAQCPPAFIADPKLVNIAQECIGSLKLNAVRGLICSGDAFINGAEPLARIRRTFPEVVAVEMESTAIGHVCHQFDTPFVVVRAISDVADKESHLSFDEFLSVAAQQSSLMVTTMLDKLKTETQF
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: LRRC2_MOUSE
Sequence: MGHKVVVFDISVVRALWETRVKKHKAWQKKEAERLEKSALEKIKEEWDFVAQCRRKGVPQAEYCKNGFVDTSTRLLEKIERNSVSRQSARVKDRDKRRSPFVFELSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPPELGDCEHLERLDCSGNLDLMDLPFELSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNNLSDLPQDIDRLEELQGFLLYKNKLTYLPQAMLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDNPIDKTGCQDTEDTVESERDRQHFDKEFMKAYIEDLKEREAVPSYTTKVSFSLQL
What are the official names of this protein?
Leucine-rich repeat-containing protein 2.
Protein: LOLB_VIBA3
Sequence: MSKLRKITSLIFLTIIMVGCSSIPEQPTSVEWQSHQNRLLQIENYQASGKLAYISPEQRQSLNFIWKHSPNQSQLRLTTFLGQTALNLTIDSLGAKVVTYDDQVFTHASASVLVEQLTGLQIPIDHLPQWFLGIPDQADSYQLNSTNTLESLSKQVSSQLWTLNFANYRNTEMQSKQLSDKDNVKVETIPLPTRLSFKQDENKINIVVSKWTLKK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: KDUD_BACSU
Sequence: MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSHTSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREKAEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYTASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGRWGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR
What is the function of this protein?
Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH.
What are the official names of this protein?
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase, 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxygluconate oxidoreductase, KDG oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NU1M_PARTE
Sequence: MLIYSIVLMLVVTLIIASITLLERKLLSLVQRRVGPNFVGYKGRLQYLADALKLFLKGVAIPSGANSFFFVAMPSLAGAVCYTFWMNSIWGPSLSMFDVEYNIVYASLLSILFGLCVMLTGYFSKNKYSVMAGLRAAILMLNLEIFLGIVFLNVCFLVESFSFAAFAVYQEIFWLIFLFFFLLSNILLVFLLEVNRTPFDLAEAESELVTGYTTEYGGFYFALFYLGEYFHLFFFSCLISVVFFGSWELLKPFLFLHNYTV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KS6A6_HUMAN
Sequence: MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
What is the function of this protein?
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
What are the official names of this protein?
Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, 90 kDa ribosomal protein S6 kinase 6, p90-RSK 6, p90RSK6, Ribosomal S6 kinase 4, RSK-4, pp90RSK4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.
Protein: PNP_ACIBY
Sequence: MSMFNIVRKEFQFGQHQVVLETGRVARQANTVLITMGGVTVLVAVVAAPTAKAGQDFFPLTVNYQEKQYAAGRIPGGYGKREGRASEAETLISRLIDRPIRPLFPEGYYNEIQVTATVVSSDKTMEADIAAMLGTSAALAIAGTPFRGPIGAARVGLINGEYVLNPNFEQMAQSDLDLVVAGTESAVLMVESEAKELSEDQMLGAVLFGHDEMQIAIQAINEFAAAAGAKPSDWVAPAHNEELRAKLKEAFEAKISEAYTIAVKQDRYAALDALHAEAVAQFVPEEDVDGIADEVDYLFEDLKYRTVRDNILSGKPRIDGRDTKTVRALDVQVGVLERAHGSALFTRGETQALVTTTLGNTRDALMVDTLAGTKTDNFMLHYNFPAYSVGETGRESGPKRREIGHGRLARRGVQAVLPAADRFPYVIRIVSDITESNGSSSMASVCGASLSLMDAGVPLKAPVAGIAMGLVKEGERFAVLSDILGDEDHLGDMDFKVAGSANGITALQMDIKIEGITEEIMEVALNQAFAGRMHILNEMNKVISRARPEISMHAPTFEVITINPDKIRDVIGKGGATIRQITEETKAAIDIEDNGTVRVFGETKAAAKAAIAKIQAITAEVEPGKIYDGKVIRIVEFGAFVNIMPGTDGLLHISQISNERIANVTDVLKEGQEVKVQVQDVDNRGRIKLTMKDIEQA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSK_STRR6
Sequence: MANKNTSTTRRRPSKAELERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGLLIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWSVYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGEILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPSLQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFRELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQVKFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRGDMLFKPIDENHPVRLQGSFISDDDVERIVNFIKTQADADYDESFDPGEVSENEGEFSDGDAGGDPLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEIAGVIGPAEGTKPRKVLQQ
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity).  Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination.
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: HCN1_HUMAN
Sequence: MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
What is the function of this protein?
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084).  Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).  May mediate responses to sour stimuli.
What are the official names of this protein?
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel HCN family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTFB1_ECOLI
Sequence: MSKKLIALCACPMGLAHTFMAAQALEEAAVEAGYEVKIETQGADGIQNRLTAQDIAEATIIIHSVAVTPEDNERFESRDVYEITLQDAIKNAAGIIKEIEEMIASEQQ
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II FryABC PTS system is involved in fructose transport.
What are the official names of this protein?
PTS system fructose-like EIIB component 1, Fructose-like phosphotransferase enzyme IIB component 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_THET2
Sequence: MIPEGTRFLLPPEARLKAEVVGKLQHLFRRHGYEPVELPALELYDPDHPLAERAFKLVDKTGEVLALRSEFTTLLAKLLRAHLGEGAHRFQYAGPLWLREADAELGRLREYTQVGLELLGATGPLADAEVLELAFAALEALGVQGEVEVGLPSLVGEVLKASGLPEALQRRAQQAIHRKNLPELKGLLAESPVPEEARKVLLALPDLYGGREVLKEARGLPLPPKAQEALAQLERTLDLLGRPVLLDLGMARRYEYYSGIFFRAYTPGFGLPLLGGGRYDGALFPKAAGFALGVERLLEALRLPKEEEPPEVLALDLKALRRFARERRTELFHGEDPVAYARRRGIPFLARGEELFRVEEA
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.