PharMolix/UniProtQA huggingface dataset:
Protein: BICC1_MOUSE
Sequence: MASQSEPGYLAAAQSDPGSNSERSTDSPVAGSEDDLVAAAPLLHSPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEDTGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGILQPVPDPNTPSIQHISQTYSVSVSFKQRSRMYGATVTVRGSQNNTNAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNVKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEDIEVDPQVIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSATPNSLLNALNTSVSPLQSSSSGTPSPTLWAPPIANTASATGFSTIPHLMLPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKNISASINGHVQPANMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGCNDAFVEVGMPRSPSHSGNAGDLKQMLGASKVSCAKRQTVELLQGTKNSHLHGTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQKSERARLASQPTYVHMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSSLSLSRSSSREHLASGSESDNWRDRNGIGPMGHSEFSAPIGSPKRKQNKSREHYLSSSNYMDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELSKNRRKLFEPPNASCTSFLEGGASGRLPRQYHSDIASVSGRW
What is the function of this protein?
Putative RNA-binding protein.  May be involved in regulating gene expression during embryonic development.
What are the official names of this protein?
Protein bicaudal C homolog 1, Bic-C.
What is the protein family that this protein belongs to?
Belongs to the BicC family.
Protein: FADI_SALSV
Sequence: MRQALPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPADAIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKALARVLVDVNKARTTRQRLTLFSRLRLRDLLPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWAEGKLAEEVMTTYVPPYKNPFAEDNNIRGTSTLADYAKLRPAFDRKHGSVTAANSTPLTDGAAAVILMTESRAKELGLHPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMADLTLFDMHEAFAAQTLANLQLLGSERFAREVLGRAQATGEVDDAKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STC2_STAAU
Sequence: MKKQIISLGALAVASSLFTWDNKADAIVTKDYSKESRVNENSKYGTLISDWYLKGRLTSLESQFINALDILETYHYGEKEYKDAKDKLMTRILGEDQYLLERKKVQYEEYKKLYQKYKEENPTSKGLKLKTFDQYTIEDLTMREYNELTESLKSAVKDFEKDVEKIENQHHDLKPFTDEMEEKATSRVDDLANKAYSVYFAFVRDTQHKTEALELKAKVDLVLGDEDKPHRISNERIEKEMIKDLESIIEDFFIETGLNKPGNITSYDSSKHHYKNHSEGFEALVKETREAVANADESWKTKTVKKYGESETKSPVVKEENKVEDPQSPKFDNQQEVKTTAGKAEETTQPVAQPLVKIPQGTITGEIVKGPEYPTMENKTLQGEIVQGPDFPTMEQSGPSLSDNYTQPTTPNPILEGLEGSSSKLEIKPQGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRDAGTGIREYNDGTFGYEARPRFNKPSETNAYNVTTNQDGTVSYGARPTQNKASETNAYNVTTHANGQVSYGARPTQKKPSETNAYNVTTHANGQVSYGARPTYNKPSETNAYNVTTHGNGQVSYGARPTYKKPSKTNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHGNGQVSYGARPTYNKPSKTNAYNVTTHADGTATYGPRVTK
What is the function of this protein?
Staphylocoagulase is an extracellular protein which specifically forms a complex with human prothrombin.  This complex named staphylothrombin can clot fibrinogen without any proteolytic cleavage of prothrombin.
What are the official names of this protein?
Staphylocoagulase.
What is the protein family that this protein belongs to?
Belongs to the staphylocoagulase family.
Protein: GRPE_NITEC
Sequence: MQEPHNQEPIEEQKLSEMEDTLEKQHSGASTENTERAEEGVVIPDLEQQLKEAEIRAAEHHDAWLRAKAETENIRKRAQTDIANAHKYAIDNFATQLLAVMDSLDAALAVENSTIESLKDGVELTRKQLAAVFEKFNIHTINPQGEKFDPHQHEAMCTVESDIPPNTVTQVMQKGYVLHERVIRPAMVAVSKAKST
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCAI_ECOLI
Sequence: MKITTVGVCIISGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQDAIVEITATDGMTTHYGQITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQHQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAFAALLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVTFITVPLILAAMVVHLSGPLILEQGLWFLADRSLALLFWGLKSLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLPAMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPHQGQTTVNFSAQGWRISSLREQILPRWYHQWFGVPVDNG
What are the official names of this protein?
Uncharacterized protein YcaI.
What is the protein family that this protein belongs to?
To B.subtilis ComEC, N.gonorrhoeae ComA, and H.influenzae Rec2.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU1_SHIF8
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: CLPX_AZOC5
Sequence: MSKTGGSDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREESKSSLVKSRDGIPTPKEIRKVLDDYVIGQDHAKKVLSVAVHNHYKRLNHATKHGDVELAKSNIMLIGPTGSGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDKIISSRSKGGTSIGFGAKVAPVEERRPGELFREVEPEDLLKYGLIPEFIGRLPVLATLNDLDEAALKQILAEPKNALVKQYQRLFEMENVDLTIHEEALGAIARKAIERKTGARGLRSIMEGILLDTMFDLPGLEGVEEVVISKEVVEQNARPLYIYADRVGDAGASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: Y2035_DEIRA
Sequence: MFLLRPPTPAQVAAFVARSREQAPSYAETGWSLDGRTPDWARSGRHRVRVGEGEACWERAKAALRGGQMFQDWVLRPHGEASTPLSRQGATVVLLVRHFGPWGRRKWGLYSLMTNRVLYLVDEPDRYGFGYGTLPGHLVRGEERFLLERDAGGAVWFDLTTFSRAALPFSRFAQPLVGAAQRRGARHYARMLVRAAGC
What are the official names of this protein?
UPF0548 protein DR_2035.
What is the protein family that this protein belongs to?
Belongs to the UPF0548 family.
Protein: Y6506_BACAN
Sequence: MNNLSKILSGALVLSLSFNGIWAYNTTKEFDKKDKKYRVTVSEKEKQIGDLKVKLEQKDKKINEGGAGENKKEGNSTLDLQNKYREVANQFVHAYLDYSVQNKGERRNNLLKITDKKVVDIVAPNTDDLGDPNFKSHVNKAAIYINSEGDVSKKCTALLDIEYTIEGLENKQTTINSVVKITLEKQGEEIKVVEYNPYPVKR
What are the official names of this protein?
Uncharacterized protein pXO2-07/BXB0006/GBAA_pXO2_0006.
Protein: OR1E1_HUMAN
Sequence: MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPMYLFLSNLSFSDLCFSSVTIPKLLQNMQNQDPSIPYADCLTQMYFFLLFGDLESFLLVAMAYDRYVAICFPLHYTAIMSPMLCLALVALSWVLTTFHAMLHTLLMARLCFCADNVIPHFFCDMSALLKLAFSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSILKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCSSANSSTLKDTVMAMMYTVVTPMLNPFIYSLRNRDMKGALSRVIHQKKTFFSL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1E1, Olfactory receptor 13-66, OR13-66, Olfactory receptor 17-2/17-32, OR17-2, OR17-32, Olfactory receptor 1E5, Olfactory receptor 1E6, Olfactory receptor 5-85, OR5-85, Olfactory receptor OR17-18, Olfactory receptor-like protein HGMP07I.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNFD_HAEDU
Sequence: MFKMVSSPHTHGTNLTAKFMLWVIVAMLPALIVQIAFFGTGVVIQLAIALSMAIVIEIVVAKLRHKSTTFYLADLAGVVTATILAMAIPPYAPYWVVMIGMIVALLLAKHCYGGLGQNLFNPAMVAYAFLLISFPVQMTSWLPSFELLAEPPTFKDAWLLIFKGVTSDGFTSRQLLSGIDGIAQATPLDSAKTSIAKLGFDGVIQSPIFSGIFARGWLQLNLAFLAGGLFLLYKRIIHWQIPVAMLVVFSVLSALTDLVTMHTHLNVLSQLFSGAMMFGAFFIATDPVSASITPKGKLIFGGLIGLLAYLIRYYGSYPDAIAFAVLLANLCVPLIDHYTQPRLYGTHK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAND_ENTFA
Sequence: MKVTMLKGKIHRAKVEQAELDYVGSITVDMDLLEAAGIYEYEKVQIVDVNNGNRFETYTIAGERGTGMICLNGAAARCVSTGDKIILMAYCELNENEVKDHRPKVVFVDDNNKVERVTSYEKHGRLSDIIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NYLC_FLASK
Sequence: MNTTPVHALTDIDGGIAVDPAPRLAGPPVFGGPGNDAFDLAPVRSTGREMLRFDFPGVSIGAAHYEEGPTGATVIHIPAGARTAVDARGGAVGLSGGYDFNHAICLAGGAGYGLEAGAGVSDALLERLEHRTGFAELQLVSSAVIYDFSARSTAVYPDKALGRAALEFAVPGEFPQGRAGAGMSASAGKVDWDRTEITGQGAAFRRLGDVRILAVVVPNPVGVIVDRAGTVVRGNYDAQTGVRRHPVFDYQEAFAEQVPPVTEAGNTTISAIVTNVRMSPVELNQFAKQVHSSMHRGIQPFHTDMDGDTLFAVTTDEIDLPTTPGSSRGRLSVNATALGAIASEVMWDAVLEAGK
What is the function of this protein?
Involved in the degradation of nylon-6 oligomers (PubMed:8285701, PubMed:17827307).  Degrades cyclic and linear oligomers of 6-aminohexanoate (Ahx) with a degree of polymerization greater than three by an endo-type mode (PubMed:8285701, PubMed:17827307).  Cannot use Ahx cyclic dimer or the Ahx linear dimer (PubMed:17827307).
What are the official names of this protein?
6-aminohexanoate-oligomer endohydrolase, 6-aminohexanoate oligomer hydrolase, Ahx endo-type-oligomer hydrolase, Nylon hydrolase, Nylon oligomer-degrading enzyme EIII, Nylonase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S58 family.
Protein: RL17_SHEB9
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTVAKAKELRRVVEPLITLAKSDSVANRRLAFARTRDAEVVGKLFTELGPRYQERPGGYTRILKCGLRAGDKAPMAYIELVGRPEAAQAVDVEAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: NQRE_PSET1
Sequence: MEHYISLFVKAVFIENLALSFFLGMCTFLAVSKKVTTSIGLGVAVIVVLGISVPVNNLVYHAVLAPGSLTWLGYPDADLSFLRFLTFIGVIAALVQILEMALDKFFPALYNALGIFLPLITVNCAIFGAVSFMVERNYNFGESVVYGIGAGVGWALAITLLAGIREKMKYSDVPDGLRGLGITFITVGLMALGFMSFSGISL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH10_TETHA
Sequence: MLKPLGDRVLIEVSEEEEKTVGGIVLASTAQEKPQTGKVVAVGPGRTLDNGELATVPVNVGDTVLFEKYAGSEVKYDGQDYMIFSAKDLVAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNF59_SCHPO
Sequence: MEEEDITLEHSDDLNKEESGESNRVNIEEPEHHDNSNKESTNLDDLNMLEEPKYHDNSNKESTNLDDLNMLEEPEHHDNSKKESTNLDDSNMLEEPKHHDNSNKESTNLDDLNMSEEPKHHDSSNKESTNLDNSNMDESENQKNFKIEEPKPSGDFRNEGPKQCDDSKIEKPELHVNSKIEEPIHRIDSEHNEPEYHTESKNEESEHNTKSIREEPIHHVDSKNEEPVYSKIPEKMGDEFSENSLSKSDSAVKQEGNLLIHPNNSLKDTAPSKCKEPPVDEALSKKEISDDIAQITSVTPITEKIEDKDKYISEVIDTYGKLADGFEYRAKTFCLEGRGKVLYMLGTECSRLLGFKDSYFMFHKTPSLRKVLTTQSERDQMVEMGLLASNFRFRQLSIVPARQMFLAFGARILMKGTIDPESHKALIEKNISWADDEYYHMDVMANGSTRSSSVKLELKSMDNQNSPSPFQGKDILTLAQGASFYNSKVMRTRNLRKEARLSYYTKLRGVNRSVS
What is the function of this protein?
Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
SWI/SNF global transcription activator complex subunit snf59.
What is the protein family that this protein belongs to?
Belongs to the RSC7/SWP82 family. SWP82 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: METE2_ORYSJ
Sequence: MASHIVGYPRMGPKRELKFALESFWDGKSSAEDLEKVATDLRASIWKQMADAGIKYIPSNTFSYYDQVLDTTAMLGAVPERYSWTGGEIGFSTYFSMARGNATVPAMEMTKWFDTNYHFIVPELGPNTKFSYSSHKAVNEYKEAKALGVDTVPVLVGPVSYLLLSKPAKGVEKSFALLSLLSSILPVYKEVIAELKAAGATWIQFDEPTLVLDLDSHQLAAFSAAYTELESALSGLNVLIETYFADIPAESYKTLTSLNSVTAYGFDLIRGSKTLDLVKSAGFPSGKYLFAGVVDGRNIWADDLAASLTTLESLEAIVGKDKLVVSTSCSLMHTAVDLVNETKLDSEIKSWLAFAAQKVVEVNALAKALAGQKDEAYFAANTAAQASRRSSPRVTNEEVQKAAAALRGSDHRRATNVSARLDAQQKKLNLPVLPTTTIGSFPQTVELRRVRREYKAKKISEDEYVSAIKEEISKVVKIQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPIIYGDVSRPNAMTVFWSKMAQSMTSRPMKGMLTGPVTILNWSFVRNDQPRFETCYQIALAIKKEVEDLEAGGIQVIQIDEAALREGLPLRKAEHAFYLDWAVHSFRITNCGVQDTTQIHTHMCYSNFNDIIHSIINMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTEEIADRINKMLAVLDTNILWVNPDCGLKTRKYTEVKPALTNMVLAAKLIRTQLASAK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2, Cobalamin-independent methionine synthase 2.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: DIB1_CANGA
Sequence: MEFLYNLHSGWHVDQAIVTEEERLVVVRFGRTADRECMLMDEMLASVAEKVRNFVAIYLCDIDEVPDFNDMYELNDNMCLMFFYKNKHMMCDFGTGNNNKMNFLPDDKQELIDIMETIFRGARKNKGIVVSPYDYNHKRPSD
What is the function of this protein?
Essential role in pre-mRNA splicing.  Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis (By similarity).
What are the official names of this protein?
Spliceosomal protein DIB1.
What is the protein family that this protein belongs to?
Belongs to the DIM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCAP_RSVM
Sequence: MGTNKPATLADLQKAINDISKDALSYLTAHKADVVTFAGQIEYAGYDAATLIGILKDKGGDTLAKDMTMCITMRYVRGTGFVRDVTKKVKVAAGSTEASTLVSRYGIVSSVGTNANAITLGRLAQLFPNVSHEVVRQISGVKMAVDSSDLGLTGCDNLLWDYVPQYIKLESETAPYCSTHSLSHILFVVHIIHSFQITKKTMPEGKKKERGLTKDIDMMKYTTGLLVITCKSKNLSDKKKEEGRKKVLDEFITNGKVKTTIFDALAGMSVNTISTYGNQTRLYLAQQSKLMKILAENTSKTATEVSGLVKEFFEDEAEGADD
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC), and serves as template for viral transcription and replication (By similarity).
What are the official names of this protein?
Nucleoprotein, Coat protein, CP, Nucleocapsid protein, Protein N, Protein pc3.
What is the protein family that this protein belongs to?
Belongs to the tenuiviruses nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: WIPI2_RAT
Sequence: MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLVTQTYGTAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.  Involved in an early step of the formation of preautophagosomal structures.  Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases.  Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P.  Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 2, WIPI-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P.
Protein: ABAH1_SOLLC
Sequence: MVNYFEIFLYISMFVLGYLSYYFCFGKNNNSSSKKNAYKLPPGSMGWPYIGETLQLYSQDPNAFFINRQRRFGEIFKTKILGCPCVMLASPEAARFVLVNQANLFKPTYPKSKENLIGQSAIFFHQGDYHNHLRKLVQAPLNPESIRNQIPYIEELSISALNSWVGGHVVNTYHEMKKFSFEVGILAIFGHLDGHVKEELKKNYSIVDKGYNSFPINLPGTLYRKALQARKKLGKILSEIIREMKEKKTLEKGLLSCFLNAKEEKGFLVLNEDQIADNIIGVLFAAQDTTASVLTWIIKYLHDNPKLLECVKAEQKVIWQSNEQENHGLTWTQTRKMPITSRVVLETLRMASIISFAFREAVADVEYKGYLIPKGWKVMPLFRNIHHNPEFFPDPQKFDPSRFENAPKPNTFMPFGSGVHACPGNELAKLEILIMTHHLVTKFRWEVVGSGSGIQYGPFPVPLGGLAARFWKTTST
What is the function of this protein?
Involved in the oxidative degradation of abscisic acid, especially in pollinated ovaries.
What are the official names of this protein?
Abscisic acid 8'-hydroxylase CYP707A1, ABA 8'-hydroxylase CYP707A1, SlCYP707A1, Cytochrome P450 707A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ISPD_PROMS
Sequence: MHFLIPAAGSGSRMKAGKNKLLIDLEGESLIYWTLKSVLSANSTNWVGIIGQPKDKNLLLNSAKDFAQKVHWINGGDTRQQSVFNGLEALPKDAKKVLIHDGARCLINPELIDLCAKQLDENEAVILATKVTDTIKIVDKEGFIKETPDRNYLWAAQTPQGFLVDRLKKAHKMAIDKKWKVTDDASLFEILNWKVKIIEGTYSNIKITSPIDLKIAKLFVKNP
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: EFG_PETMO
Sequence: MKERLYPIEKIRNIGIVAHIDAGKTTTTERILFYTGTKHKLGNVDEGTTETDWMEQEKERGITITSAATSAFWKDHRINIIDTPGHVDFTVEVERSLRVLDGAIAVFDAQVGVEPQSETVWRQADRYRVPRIAFMNKMDKIGANFFNAIQTMKDKLGANPIALQVPIGSEAEFEGVVDLLTMEALYWTDENGQIIEKRSIPSNLIDFCESKREDLIAAVAEVDENIMELYIEEEEIPVDKLKEAIRTSTIQSKIVPVLCGSAFKNKGVQPLLDAVIDYLPSPLDMPPVKAFDGTTGEFVKDILPFEDGDFFALAFKIMADPFIGKLTFARVYSGTLNKGSYVVNTTKNKTERVSRLVFLHADKREEVDYIRAGDIVGLIGLKDTSTGDTLSDKECNLVLEKLEFPEPVISVSIEPETKDDEAKLGKALNALTEEDPSLRSYVDHDTGETILSGMGELHLEIIIDRIKREYKVNVKVGQPRVAYKETIKLPSEAEGKYIRQTGGRGQYGHVKLRVEPLPLNSEKEFEFVDKIVGGVIPREYIPAIENGVKESMQDGVLLGYPMVAIRVEVFDGSYHEVDSSEMAFKIAASMAFKDAIKKAKPVLLEPVMKVDVTTPEEYMGDIIADLSSRRGRIESFENVGGTNTRVVHAQVPLSELFGYATIMRSLSQGRATSSIQFSHYEEVPEQVTQKLLSRE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VGF_VACCW
Sequence: MSMKYLMLLFAAMIIRSFADSGNAIETTSPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSENPNTTTSYIPSPGIMLVLVGIIIITCCLLSVYRFTRRTKLPIQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.  This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells.  Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival.  The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo.
What are the official names of this protein?
Pro-Viral epidermal growth factor, Pro-VGF.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
What are the subcellular locations of this protein?
[Pro-vaccinia growth factor]: Host membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Vaccinia growth factor]: Secreted.