PharMolix/UniProtQA huggingface dataset:
Protein: PRM2_RATFU
Sequence: MVRYRMRSPSEGPHQGPGQDHEREEQGQGQELSPERVEDYGRTHRGHHRHRRCSRKRLHRIHKRRRSCRRRRRHSCCHRRRHRRGCRRSRRRRRCKCRKCRRHCH
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-2, Sperm histone P2, Sperm protamine P2.
What is the protein family that this protein belongs to?
Belongs to the protamine P2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FDHE_SALPA
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNVYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEANDQGKPPLDIHVLPRDKHWQKLLHSLIAELKPEMNGPALAVIENLEKASEQELEQMASALFASDFASVSSDKAPFIWAALSLYWAQMASLIPGKARAEYGEARQYCPVCGSMPVSSMVQIDTTQGLRYLHCNLCETEWHVVRVKCSNCEQSRDLHYWSLENEQAAVKAESCGDCGTYLKILYQEKDPKVEAVADDLASLVLDARMEQEGFARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_SACEN
Sequence: MPTIQQLVRKGRQDKVAKTKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSADTQGVKNRKQARSRYGAKKEKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y2743_CLOBJ
Sequence: MEEIVEMSLLLDFYGSLLTEKQNKIMDLYYNNDYSLKEISELTNTSRQAVHDIVKRCHKALLQYEEKLHMMERFINLENSKEKLLNMLNKVTKENIKEIDHIKKYIIDNI
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein CLM_2743.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: MIAA_SHEPC
Sequence: MLPKVLFLMGPTASGKTALALELAENHNCEIISVDSALIYRGMDIGSAKPSMEELARGPHRLIDIRDPSESYSAADFRADALAEIAQIIRMGKTPLLVGGTMMYFKALLEGLSPLPSADDAIRADIQAEADVKGWETLHDQLRDIDPVSAERIHPNDPQRLSRALEVYRISGKSLTELTQTKSAPLPYDVVQFAIAPRERKVLHDLIAQRFRIMLQQGFIDEVTQLKARGDLHLDLPSMRCVGYRQCWQHLDGEFDYDTMVEKAVAATRQLAKRQLTWLRSWPELNWLESGAEGNLVTLMRHCR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PRSA_STRSV
Sequence: MKKKIFAGAVTLLSVAVLAACSNSEGKDIVTMKGNTITVNEFYDQVKNNGAAQQVLLQMAIKDIFEEKYGKDVKDKDVKDAFEKSKTAYGTAFAQVLAQNGLTEDAYKEQIRTNMLVEYAVKKAAEKELTDENYKSAFENYTPEVTAQIIKVDSEDKGKEVLEKAKAEGADFSQIAKENSTDAATKEKGGEIKFDSGSTDVPDAVKKAAFALEENGVSDLVTVPDSQYSASYYIVKLVKKSEKSSNWKDYKDKLKKIIIAQKEKDTSFIQSVVAKELKDANIKVKDSAFQSVFAQYIETTGSSTSSSSAASSSKTSESSSAAESSSKEASSSAAE
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: IHFB_SERP5
Sequence: MTKSELIERLAGQQSHVPAKAVEDAVKEMLEHMAATLADGERIEIRGFGSFSLHYRAPRVGRNPKTGDKVELDGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ECFA1_MESHJ
Sequence: MIKVSDVCFSYTNNMDQLVLKNINVVFEKGKYYAILGHNGSGKSTFSKILSGIFKPQKGSIEVDGVLLNKENLTKIRKKIGIIFQNPDNQFVGATVEDDIAFSLENINEDPKKMSQIIANLAAKVQMESYLDREPQFLSGGQKQKVAIASVLALNPEIIIFDEITSMLDPRGKYDVVKILDDLRKDKTKTLISITHNMNEAILADEIIVFANGGIIAQGDPKLILNDKNIIEKAKIDSPFIYKISSALKLVSPTYDENELLEQLWKLKQKTS
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CYMEF_MELDN
Sequence: GLPICGETCFFGKCNTPKCTCINPICYKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide mden-F.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family.
Protein: Y1469_HAEIN
Sequence: MESITVFSAGSFCYALQELSDIFRQIHHIEIKAFCGPAGILRQQIEQGNRGDIFISANPGNVLQLADSKKIYQKLTIAFNQLALTTLNLEHFRHKSIFELLFDRSFLGVKNVSKY
What are the official names of this protein?
Uncharacterized protein HI_1469.
Protein: DDL_CUPNH
Sequence: MSFVAHPNIDPKSLGKVGVLLGGRSAEREISLMSGNGVLAALQSRGVDAHGFDPGLQSVAELAAAGFDRVFIALHGRYGEDGTIQGLLEQLGVPYTGSGVLASAMAMDKQATKRLWMTYGLATPRFAMLHADTDFDAVAADLGLPLIVKPAREGSSIGLTKVTAADQMRAAFEKAAALDNDVIAETFIDGAELTCPIVGEGDSAEALPVIRIVAPEANYDYQNKYFTDDTQYLCPSGLDPEVEREVRALAVQSYRVLGCRGWARADLMLRADGKPFLLEMNTSPGMTGHSLVPMAARAVGISYEDFVMQVVAAATLDLHPNEHWKPE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTDC1_XENLA
Sequence: MSTLLLVEAFYGGSHKQLMDLIKEEVEGCILYTLPAKKWHWRARTAALYFMQAILPSDTYRVLFTSSVLNLAELVALRPDLGKLKKILYFHENQLIYPVQKSQERDFQYGYNQILSCLVADTVVFNSAFNMESFLTSIKTFLKKIPDHRPKNLEEIIRPKCRVLYFPINFPDIRQYLPEHKCIPHNLVDKSSSDISYCPKTSIQTGRMSVEFSDHQIQCSIDESSAEQEKTTVSEKNNCEGVDHVILHSQSTLAGDIHQEKPLHIVWPHRWEHDKDPETFFKVLLKLKEKELTFHLSVLGETFTDVPDIFSEARITLGSSVLHWGYLASKDDYLQALCMADVVVSTAKHEFFGVAMLEAVHCGCYPLCPKSLVYPEIFPAVYLYSSPEQLLRKLEDFCKRPDIVRRHRFQGETERFSWAALRGEFRSLLDAEPREDL
What are the official names of this protein?
Glycosyltransferase-like domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: PAXM_PENPX
Sequence: MEKAEFQVIIVGGSIGGLTLAHCLHRAGIKHVVLEKASDPAPQIGASIGILPNGARVLDQLQLYDQVEEHIEPLSKATIGLPDGFNFSSSYPKIIDQRFGFPIAFLDRQKMLEILYKGYPDPSKIRLGQRVTSIESLDDGVLITTTTGHVYRGDLLVGADGVHSIVRREIWKARGIARRVSKIKQDSSKLTVEFRCIFGISSAMPGLKLGEQVNALFDGLTIVTIHGKDGRIYWFVIQKLGKKYVYPDSPRYTSHETSIAAEEIRDVKFYENITFGELWDKRETSSMTALEENTFKVWHHGRCVLLGDSVHKMTPNVGQGANMAIEDAAALANLLRKMRISSGPYFPTSSQMEFLLQKYRDLRYERVNTIYQSSRFLVRFQVRDGIIYSLLSRYWAPYAGDLPADMASKTIADGTMCDFLPTPKRSGGGWEKYSKQGRSWSYLTQLMIYLFGLTIVYTSLTMMFDLEGALKFYFLQV
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005, PubMed:16494875).  PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005, PubMed:16494875).  Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005, PubMed:16494875).  Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005).  Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005).
What are the official names of this protein?
FAD-dependent monooxygenase paxM, Paxilline synthesis protein M.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UNG_MONPV
Sequence: MNSVTISHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDHQFEKDRSFEIINVLLELDNKTPINWAQGFIY
What is the function of this protein?
Plays an essential role in viral replication as a component of the DNA polymerase processivity factor.  Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Protein: SYDND_THEPX
Sequence: MGEQLNGLKRTHMCGELTVEDVDKYVVVMGWVQRRRDHGGLVFIDLRDRTGIVQVVFSNEVSSEAFEKVQSVRSEYVLAIEGKVVKRSPENVNPKISTGEIEIYANTLKILSKSETPPFPIEDRSNVSEAVRLKYRYLDLRRPSMQKNLMTRFKITKVVRDFLNKNGFIEIETPLLIKSTPEGARDYLVPSRIYPGKFYALPQSPQIFKQLLMISGFDKYYQIAKCLRDEDLRADRQPEFTQIDIEMSFVEVEDVLKINEKMIAEIFKETLGIDVPIPFKRLSYQESMERFGTDKPDLRFGMELKDLSDIVAQSEFNVFKTALKNNGSVRGINVKGAASMPRRQLDELVEFAKTYGAKGLLWIQVFEKEVKSPATKFLSEEEMKKILERLEAEAGDLLLIVADKDEIVFDTLAHLRLELGKRFNLIDENKYEFVWIVDFPLLEYDEGEKRYVAKHHPFTAPKDEDIELLEKEPLKVRAKAYDIVLNGTEIGGGSIRIHDTELQKRMFKVLGFSEEKAWERFGFLMEAFKYGAPPHGGIAYGLDRLAMIITGSDTIRDVIAFPKTQNAVCLMTDAPSEVSEEQLKELHIKVDL
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWC24_NEUCR
Sequence: MADTEQPPTAPTAPEPTTATPTAPIAPVAIFKKRGAKGKANLRKRPASPPPAAKDSDDDSSDFESSEDEATGQRIKRRKKNHHSAAVMASSRDHNASTNSGVTKEEQIRSNTIYEADRDAALRLDATKQDATKGSNWFDEDNEKEDLSVGNLLGRTRTMMKTKKKVGGEDDAVQNSEREPDGTYRGLANQASYIQKNPNAPNRKVGPIKAPSNIRTITITDMAPDVCKDYKQTGFCGFGDNCKFLHAREDYAHGWQLDKEWENVTKGKKNLQGTVVASADRRNKPKNTAEEEEDADAAEEALLENIPFACIICRGPYSNSPVVTRCGHYFCEACALKRYRKDPSCAACGSGTNGVFNAAKRLAKLLEKKKARAERLRREARERGEEVSEEEDEGEDEGEGAEGSD
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor cwc-24.
What is the protein family that this protein belongs to?
Belongs to the CWC24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_ACTP7
Sequence: MAAKIRQNDEVIVLTGKDKGKRGKVTQVLPNGKVIVEGVKIITKHEKPVPALGKAGGLVKKEAAIDASNIAIFNPKTNKADRVGFRFEDGKKVRFFKSNNEII
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PYRD_BAUCH
Sequence: MLYPLIRQFLFQLDPEKAHELTIQQLKRIAGTPLEYLVRQSVPTKAVTCMGIAFKNPLGLAAGLDKNGECIDALGAMGFGFIEVGTVTPHAQIGNEKPRLFRLTKAYGLINRMGFNNKGVDNLVNNIQKSHFGGVLGINIGKNKDTPIEQGKDDYLICMEKVYPYANYIAVNISSPNTPQLTTLQSGEILDDLLRAIKDKQAKLQEYHHKYVPIAVKITPDMTESELIQMADLLVQHKIDGIIATNTTTSRELVHGLDHSSQSGGLSGRPLQLMSTEVIRILSSKLQGKLPIIGVGGIDSLISAREKMAAGATLIQIYSSFIFHGPRLIKDIISDL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPOA_PHAAO
Sequence: MVREDVVGSTRTLQWKCVESRVDSKRLYYGRFVLSPLMKGQADTIGIAIRRALLGEIEGTCITRATSENVLHEYSTIAGIEESVHEILLNLKDIVLRSNLYGVRNASICVRGPKYITAQDIISPPSVEIVDTTQHIANLTEPINLCIELQIKRDRGYRMKSTNDSHDGSYPIDIVSMPVRNANHSIHSYGNGNEKQEILFIEIWTNGSLTPKEALYEASRNLIDLLIPFLHAEEEDMNFKENENRWNLPPFSFQDKFTNFKKNKKGIPLTCIFIDQSELSSRTYNCLKRSNIHTLLDLLSHSQEDLMKMEYFRTEDVKQILSTVQKHFAINLLNKKL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACDH2_CUPMC
Sequence: MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGIDGLLAMPEFGEIRIAFDATSAGAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLDAPNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKSAGPGTRDNIDEFTETTSRAIESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRLKQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERVAQALGNHHALSAAS
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: CLPX_CROS8
Sequence: MTDKRKDSSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRSHLDDYVIGQEKAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIANRVETGSGIGFGATVKGKSQKATEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLNELSEDALIQILKEPKNALTKQYQALFNLEGVELEFRDEALEAIAKKAMSRKTGARGLRSIVEAALLETMYDLPSMEEVEKVVIDESVIAGQSEPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TSGA_ECOL5
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFLLMVLAVAGLMFSHSLALFSAAMFILGVVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMIAAFLLARSIEWYWVYACIGLVYVAIFILTFGCEFPALGKHAPKTDAPVEKEKWGIGVLFLSVAALCYILGQLGFISWVPEYAKGLGMSLNDAGTLVSNFWMSYMVGMWAFSFILRFFDLQRILTVLAGLAAILMYVFNTGTPAYMAWSILALGFFSSAIYTTIITLGSQQTKVPSPKLVNFVLTCGTIGTMLTFVVTGPIVEHSGPQAALLTANGLYAVVFVMCFLLGFVSRHRQHNTLTSH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ST1A1_HUMAN
Sequence: MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe.  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Displays broad substrate specificity for small phenolic compounds.  Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621).  Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity).  Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase 1, HAST1/HAST2, Phenol sulfotransferase 1, Phenol-sulfating phenol sulfotransferase 1, P-PST 1, ST1A3, Thermostable phenol sulfotransferase, Ts-PST.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_ENTCL
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELAGVTGCAVAIAPPDMYLDLAKHAADGSHIILGAQNVDVNLSGAFTGETSAEMLKDIGAKYIIIGHSERRTYHKESDEFIAKKFAVLKEQGLIPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKVAEQVIIQYGGSVNASNAAELFTQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR36_RAT
Sequence: MYKGETLFSIPELYPRRKQFVGQSSTRLDQCGLRLGMWYWKDETKSLEFRSFTPAVELKEKGKKGKAVHFAEMDGTASERLTDKRFVPRDEKSAKTLEKRGQQGNVTLDDVKFVALLSLQDTEMQRVCSFTTFMRNKSLDSFLMALLYYLSYYLERLSMEKKPQSYMVGLVEKKEIELVMSKLEDAQKYLAQKYCKLVLGVGMADKHHMNCGKDKISDTQKDWKFFESFYTFCTCIAWIVFRRQYLKEIEEEVGRLFRTNMFNIPRRKREDEESGGEKKRMTLVQFRRMMAKRPAIKKAMDMRSPVLSTLLPSLREKAQHIAEKKYVAGIKLQPRVEKDITNLESVVMPVVGILGEPRNLFNPHTLLPLESEENGKTSGRNSSIVERNNTSIQNTLNLVMSKLTSQNSFPK
What is the function of this protein?
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 36.
Protein: Y1856_MYCBO
Sequence: MSENRPEPVAAETSAATTARHSQADAGAHDAVRRGRHELPADHPRSKVGPLRRTRLTEILRGGRSRLVFGTLAILLCLVLGVAIVTQVRQTDSGDSLETARPADLLVLLDSLRQREATLNAEVIDLQNTLNALQASGNTDQAALESAQARLAALSILVGAVGATGPGVMITIDDPGPGVAPEVMIDVINELRAAGAEAIQINDAHRSVRVGVDTWVVGVPGSLTVDTKVLSPPYSILAIGDPPTLAAAMNIPGGAQDGVKRVGGRMVVQQADRVDVTALRQPKQHQYAQPVK
What are the official names of this protein?
UPF0749 protein Mb1856.
What is the protein family that this protein belongs to?
Belongs to the UPF0749 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIAS_CALMQ
Sequence: MITWVGIDDTDTYDKGCTTYVMYNMLKEFLKTKGEWRIITYPRLIRLNPNVPFKTRGNAAVSVGLNVDDPREALELAEWAVDAYSHKIGKTSPGIVVSISNNEHWIYWKALSDVIPLNAAVKWMSKLGVIYRGGRGVIGALASVMADLSQDSTLELLAYSESTPKPSIPIDLVKKLNDSTTPLTFENVSGDYVLIQPHGNDPVIFGIRGDSPYHIIHFASMLINEVDVEPRWLIYLTNQATGHHLNSIMNKPYTTGYVEGSVNEVRLVQGGNIEIRVNSTHVFSYRHYGFKSIDKATYLIAYGGFKPGVNSLDLYMEGGVALMLNNIVKNPRCPRCGSNLESTGRVGLLKCPKCGLITGLPRLMNYTSEFTLEEPREAEVRHLHKPTARIGLEGLVNVFNRPSLWII
What is the function of this protein?
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
What are the official names of this protein?
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS, tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the TiaS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDRP_THET8
Sequence: MKRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAYRYTAEAMTEAVVQGLEPRAMDHEALHRVARNLARQMRRVQAYEAHLQTGELRARIARYLLFLADTPLSARDRQGIYVTVSHEEIADATASIRESVSKVLADLRREGLIATAYRRVYLLDLAALEREAGSALEAA
What is the function of this protein?
Activates transcription.  Positively regulates PcrtB promoter upstream of the crtB operon in a cAMP-independent manner.  Regulated genes include genes encoding DNA photolyase, phytoene synthase and cytochrome P450 monooxygenase, which are involved in carotenoid biosynthesis.  Positively regulates the light-inducible gene cluster in the megaplasmid in a cAMP-independent manner.
What are the official names of this protein?
Transcriptional regulator LdrP, Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein LdrP, CRP/FNR superfamily protein LdrP, Light induced transcription regulator-dependent regulatory protein, LitR-dependent regulatory protein, LdrP.
Protein: CYGB_RAT
Sequence: MEKVPGDMEIERRERNEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILDVIAEEFANDFPVETQKAWTKLRGLIYSHVTAAYKEVGWVQQVPNTTTLPATLPSSGP
What is the function of this protein?
May have a protective function during conditions of oxidative stress.  May be involved in intracellular oxygen storage or transfer.  Plays a role in the development of liver fibrosis.  Has a peroxidase activity.
What are the official names of this protein?
Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_SYNJB
Sequence: MDTRAKDPASRPRLLVAASGTGGHIFPALAVAEQLPDWQIEWLGVPDRMEGKLVRERYPLHRVVMSGWQGSPLHRLQALAQLARATLQVRRLLMSGRFDIVLTTGGYIAAPAILAARSLGVPVLLHESNWIPGKVTRWLGRFCQVVALGMAETAEHLPGVAAQVVGTPVRAEFYTPQPFPADLPIPDGDPLIVVMGGSQGARGLNRMVATCAPAWLEAGAWIVHLTGGSEAQDPEARIPSHPRYRPFPFRRDVAALLQRANFAISRAGAMSLAELLTTATPAILIPYPFAAEDHQYQNALAFVGRGGGVVMRESEENLDLLRQTVLTWLAQPQVVAQMAARLQAAAPPNASKVLARLLQEIRQSSAR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.