PharMolix/UniProtQA huggingface dataset:
Protein: ATZA_PSESD
Sequence: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL
What is the function of this protein?
Hydrolytically dechlorinates atrazine to hydroxyatrazine.  Dechlorinates also simazine, and desethylatrazine but is not active with terbutylazine or desethyldesisopropylatrazine (PubMed:8759853).  Has no deaminase activity with melamine (PubMed:8759853, PubMed:22768133).
What are the official names of this protein?
Atrazine chlorohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO1_SOLTU
Sequence: AQAAPVPRPVXLSKKTDSF
What is the function of this protein?
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: BUB3_SCHPO
Sequence: MNFSKTLLKNSKDGISSVIFSPSVKNELIAGCWDGSLLHYQISENPELLGKYDLSSPILSLEYTDEKTALVGNLDGTVTTLDLNTRNHEFLGNHGKGVSCISKLRLENCFISGSWDKSFRVWDVRVKQPVEGQDIGKKIFASSSRDNILVLGCSERENLVYDIRNLKLPFQRRPSSFKYMTRSVCCNQNFEGFVSSSIEGRTSVEYINPSQEAQSKNFTFKCHRQIQKDYDIVYPVNDLKFHPIHQTLATAGGDGVVAFWDIQVRKRLRVLNPSKINISSISFNVDGSMLAIATCAQEEAAGNIYVHALESNFAAPKLKS
What is the function of this protein?
Involved in cell cycle checkpoint enforcement.  Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function.
What are the official names of this protein?
Mitotic checkpoint protein bub3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BUB3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Associates with kinetochores and centromeres during the early stages of mitosis.
Protein: RGRF2_MOUSE
Sequence: MQKSVRYNEGHALYLAMLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHDGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIATNQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSSPTTTTHSPAASPPPHTAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHCSVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPRLPA
What is the function of this protein?
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP.  Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.  Functions in synaptic plasticity by contributing to the induction of long term potentiation.
What are the official names of this protein?
Ras-specific guanine nucleotide-releasing factor 2, Ras-GRF2, Ras guanine nucleotide exchange factor 2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity).
Protein: RK20_CHLVU
Sequence: MTRVKRGNVARKRRKQVLNLASGFRGSSSRLFRTAQQQTMKALSYSYRDRQQKKREFCGLWVTRLNAAARLYGLNYTNFRHNLKKAGIQLNRKVLSQVALRDKQAFEQLILLVKD
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL9_BURCH
Sequence: MQIILLEKVANLGNLGDIVKVKDGYARNFLIPNRKARRATKEAIAEFEVRRAELEKIAAEKLAASQAVGEKLNGQSFEITQKSGVDGRLFGSVTNGDVAELLKKAGYEVEKLQVRMPEGPLKMIGEHNVQVALHTDVVVDVTINVIGDHA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: COBT_SALSV
Sequence: MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLEALAVQLAGMPGLNGTPQVGEKAMLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVDMRVARGCGNIAVGPAMSRSQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: LACR_STAEQ
Sequence: MNKYDRLDEITKLVNKRGSVRTNEIVEDLNVSDMTVRRDLAELEEKGVLTKIHGGARSNSAFQYKEMSHQEKHTRFIEEKRFIAKNAVDLIEDGDTIFLGPGTTVQKLAEEINHYSLTIITNCLPVFNILIKKQTLHFRVYLLGGEMRDLTEAFVGEMTNQLLSQLRFSKMFFSSNGVKDGLAMTSSIEEAYTQQIALSHSLEKYLLIDSSKIGKDDFSSFCELRELNAVLTDNNDLEKKEKIESYVEVIS
What is the function of this protein?
Repressor of the lactose catabolism operon.  Galactose-6-phosphate is the inducer (By similarity).
What are the official names of this protein?
Lactose phosphotransferase system repressor.
Protein: TRHO_NEOSM
Sequence: MEKFTLVTFYHFVQLENYEDMRDELLSCCIEKGLKGTVLLALEGINGSVAGHDGEIRDFLDFVRRDERLRGLEWKESYTNFQPFQEMKVRLKKEIVALGCAELENMEICETGEYVEPEDWSSLIAREDVKTIDTRNLYETKLGRFKYSIDPETINFRDFQEWVRKWIEKDNVSMEQKIAMYCTGGVRCEKSTAYMKRIGFKNVYQLKGGIINYFLKTKNKDGAWVGDCFVFDDRVAVNVDLEPIQLKCLECSCVVNTDDLKNIPRGRVLCSGCGQNTTRFS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TKT_MYCTU
Sequence: MTTLEEISALTRPRHPDYWTEIDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGKAHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWARREPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGSADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPRLSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDAGGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAVLPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFREYGFTAEAVAAAAERALDN
What is the function of this protein?
Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate.  Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: GPR_CLOAB
Sequence: MNSVRTDLAVEAREMYCEKTENGDNGVRVDTKRIEDIEITTVDVLNDKGEERIRKQKGTYITLDIPKVTLYDSEDIEEISKVFADELSKIISKAKLDSSMTVLVVGLGNWNITPDSLGPKVIGKLMVTRHLKKYIPDSIDEGIRPVCAVAPGVLGITGMETGEIIRGIVQNIKPDLIVCIDALAARKMGRVNSTIQIGNTGISPGSGVGNMRMELSQKTLGVPVIAVGVPTVVDAATMANDTIDIVIEKMKGEVSEDSKFYSLLKAIDTEEKSQLIYEVLNPYVGDLLVTPKEVDMIMETLSKIIASGINIALQPALELSEINKYVN
What is the function of this protein?
Initiates the rapid degradation of small, acid-soluble proteins during spore germination.
What are the official names of this protein?
Germination protease, GPR endopeptidase, Germination proteinase, Spore protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase A25 family.
Protein: HSLV_STAHJ
Sequence: MSKTSLHATTIYAVRHNGEAAMAGDGQVTLGEQVIMKQTARKVRRLYEGKVLAGFAGSVADAFTLFEKFETKLQQFSGNLERAAVELAQEWRGDKQLRQLEAMLIVMDKDAILVVSGTGEVIAPDDDLIAIGSGGNYALSAGRALKRHASQLSAKEMAYESLKVASDICVFTNDNIIVETL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_ECO57
Sequence: MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKEGTEEPWYVVDKDVENNILIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDDDRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPC_CROS8
Sequence: MAMLRPALTLLVFLTILTGGVYPLATTVLGQWWFKDQAEGSLIRQHDEVRGSRLIGQAFSEAKYFQGRPSATAEAPYNPMASGGSNLAASNPALDKEVQARVQALRAANPDARAAVPVELVTASASGLDYGITPDAAFWQAPRVAQARGISEAEVGRLIRENTDAPLAGFLGQPVVNVLKLNMALDALQP
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PSBI_PROM9
Sequence: MLALKISVYTIVFFFVGIFLFGFLASDPTRTPNRKDLESPQD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: AROC_YERPE
Sequence: MAGNSIGQFFRVTTFGESHGIALGCIIDGVPPGIPITEADIQLDLDRRRPGTSRYTTQRRELDQVRILSGVFEGVTTGTSIGLMIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGVRDYRGGGRSSARETAMRVAAGAIAKKYLAQKFGVQVRGYLAQMGDVSCDLLDWDLVEQNPFFCPDASKLEPLDALMRELKKAGDSIGAKITVVAENVPVGLGEPVFDRLDADLAHALMSINAVKGVEIGDGFAVVTKRGSENRDEITPQGFQSNHAGGILGGISSGQPVVAHIALKPTSSIMVPGQTINRQGEAVEMVTRGRHDPCVGIRAVPIAEAMMAIVLMDHLLRQRAQCGDVASDVPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: CREA_ASPAC
Sequence: MPPPASSVDFSNLLNPQSNPTESTPSSPATPVDSSKGPSTPSSAQSTSSMASSVSLLPPLMKGSRPATEEVRQDLPRPYKCPLCDRAFHRLEHQTRHIRTHTGEKPHACQFPGCTKRFSRSDELTRHSRIHNNPNSRRSNKAQHLAAAAAAAAGQENAMPNNAGALMPPPSKPMTRSAPVSQVGSPDISPPHSFSNYANHMRSNLGPYARNTERASSGMDINLLATAASQVERDDHFSFHAGPRNHHLFSSSRHHGSGRLPSLSAYAITHNMSRSHSHEEDDSYSHRVKRSRPNSPNSTAPSSPTFSHDLLSPTPDHTPLATPAHSPRLRPLGSSDLHLPSIRHLSLHHTPALAPMEPQPEGPSYYSPSQSHGPSITDIMSKPDGTQRKLPVPQVPKVAVQDMLNPGSGFSSVTSSTANSVAGGDLADRAF
What is the function of this protein?
Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter.  Also plays a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
What are the official names of this protein?
DNA-binding protein creA, Carbon catabolite repressor A.
What is the protein family that this protein belongs to?
Belongs to the creA/MIG C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TNR25_HUMAN
Sequence: MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
What is the function of this protein?
Receptor for TNFSF12/APO3L/TWEAK.  Interacts directly with the adapter TRADD.  Mediates activation of NF-kappa-B and induces apoptosis.  May play a role in regulating lymphocyte homeostasis.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, LARD, Protein WSL, Protein WSL-1.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. SUBCELLULAR LOCATION: [Isoform 4]: Secreted. SUBCELLULAR LOCATION: [Isoform 5]: Secreted. SUBCELLULAR LOCATION: [Isoform 6]: Secreted. SUBCELLULAR LOCATION: [Isoform 7]: Secreted. SUBCELLULAR LOCATION: [Isoform 8]: Secreted. SUBCELLULAR LOCATION: [Isoform 10]: Secreted. SUBCELLULAR LOCATION: [Isoform 12]: Secreted.
Protein: ENO_VEREI
Sequence: MSAIVDIVGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIEMRDGDPRRYQGKGVLKAVEHVNTEISEAVLGLDASEQAFLDKTLIDLDGTENKSRLGANAMLAVSMAVARAAAEESGLPLYRYLGGMGSVQLPVPMMNVINGGAHANNSLDLQEFMIIPVGAPNFREALRWGAEVFHALKKIIHDLGMSTAVGDEGGFAPSVENHEAAIRLILQAITAAGYSAGEQIALGLDCAASEFYQDGLYVLHGEGGLKLSAPQWIDMLAAWVDKYPIISIEDGMHEGDQDGWKQLSERLRDKVQLVGDDLFVTNTRLLQQGIDQRIANSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDCTIADIAVGTNAGQIKTGSLSRSDRIAKYNQLLRIEEDLGEVAQYPGRAAFRHLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: H2AV_CHICK
Sequence: MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  May be involved in the formation of constitutive heterochromatin.  May be required for chromosome segregation during cell division (By similarity).
What are the official names of this protein?
Histone H2A.V, H2A.F/Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
Protein: HISZ_BURO1
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADITPQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLGHAGVLAALLARDAQAAERGESLYDALSGKDVPLLNELTDDLGADTRAALRALPNLYGDASVLAEARTRLPVLPEITRALDDLAQLASQAKGVEVAIDLADLRGYAYHSGAMFSAYIDGVPNAIARGGRYDHVGQAYGRSRPATGFSLDLRELARISPVEARGTAILAPWAQDDALGAAVAALRDAGEVVIQALPGHDHVLDEFACDRSLVERNGAWVVEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
Protein: TERB_ASPTN
Sequence: MKVDMHQAEQWPSQRLLGSRAPQSNDNELSWTSVLNSEEDPWLYDQILFGRRTFPVAGYVAIAGECMRQLSDSKLEFFSTKDLSIGSSLVFDPDDKLELHTTLRPQRLDEENRQWYEIEIASRNGGQSTALCTGLVAREVLDTQILPDLTRHGDSNWPVSPDYWYDMVADRGIEYGASQRGLNDISVDFTENKASATILPALDTTDSVAHPVFIDHCLQLSMVAACKGQGRLLADLSVVTSIQHLVVSNNAWSKLRVNSVVTPGRLQNLTCNFSAVNENGLPILSGQCNITPIPDLERQSDGKLFSFINWATDSTFHNLNQSLAPFQSDLDSTVALERLALLYALRSEDIGAQSQPYSKKILKKIGTKRKGRFGLVPDVSPFVGCGPSGRAELIKLLKAQISGTELSSLGHALERCLTENTPFSGSNRERQLLLDQLHPLIRNSGTLCESLRLLAYKNPKMNVLELGSGRKDSSNLVLKALRTQFDEQLYSSYLSASASLDATTGPKESSRTNGHVQPLVFDAEKSIEEQGLKAGSYDLIIITDVAALGSNAALGAKSLKRLIRPQGHVLLLEGVPEPEWLLVLKDYLTKESPEASTGSKTKSSFEDVSAALTKNGFVFEDPDNKLTSAPKVFARLKQPVPETSSEITVVGPTYHLPLIREVEKTFGDHNIKCVKSTMDDDIPPGRDIMVFVDFDEPYVYNITEAELSKFVKLVSGMKGKMIWVTPSAQIYCKNPNSSLILGLMRTMRSEFKKDITTVELDPKRTMNVSLSKSLLQIYEGLSRRGKSKDLDPDYEYAIVDGVIKTPRLQWTTAEAEYAHLASLRAEQDSGPQSCHMAATVRFRPDCCYLLVGGLGGLGRMISAWMVENGARHIIFFSRSAKEGPETTPFFDRLRAQGCTVTPFVGSVTNLPDVEEAIKQATAPVAGVIQMSAVMRVRIFAFDPEPLLTGIEG
What is the function of this protein?
6-hydroxymellein synthase; part of the gene cluster that mediates the biosynthesis of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities (PubMed:24816227).  The first step in the pathway is performed by the polyketide synthase terA that produces 4-hydroxy-6-methylpyranon (4-HMP), orsellinic acid (OA), and 2,3-dehydro-6-hydroxymellein (2,3-dehydro-6-HM) by condensing acetyl-CoA with two, three, or four malonyl-CoA units, respectively (PubMed:24816227).  4-HMP and OA are not pathway intermediates, but are rather shunt or side products (PubMed:24816227).  2,3-dehydro-6-HM is further converted to 6-hydroxymellein (6-HM) by the 6-hydroxymellein synthase terB (PubMed:24816227).  The monooxygenases terC and terD, the multicopper oxidase terE and the Kelch-like protein terF are then involved in the transformation of 6-HM to terrein (PubMed:24816227).  Even if they are co-regulated with the other terrein cluster genes, terH and terI seem to be dispensable for terrein production; whereas one or both of the 2 transporters terG and terJ are probably required for efficient secretion of metabolites (PubMed:24816227).
What are the official names of this protein?
6-hydroxymellein synthase terB, Terrein biosynthesis cluster protein terB.
Protein: SYN_GEOSL
Sequence: MNERIRIREILAGTPAGTEVIVKGWVRTSRVGKGVAFLAVNDGSCLASLQVVAEPGLANYHELRGIGTGAAVAVRGIVAESPAAGQAVELHATKVVVVGGADEQYPLQKKRHTFEYLRTIAHLRPRSNTFGAVFRVRSSLAQAVHRFFAERGFLYVHTPIITTSDCEGAGELFRVTTLDPSAPPMADGAVDFSQDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAAEFWMIEPEMAFADLRDDAALAEDFFRYLCRHVLDNCAEDMAFFNEHVDRGLLARVEQVAGSSFAMMEYGVAIEHLKRAAVPFEYPVEWGLDLQTEHERYLTEQVVGGPVFVVNYPQEIKAFYMRRNDDGRTVAAMDLLVPKVGEIIGGSQREERYDLLESRMREGGIAPESLWWYLDSRRWGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_CYAPA
Sequence: MTFDYTNSFYNYDQYNNKKFDIVVLKPLKEEEIEYYLMQSLDALRINKAVVFNFEHIDYPLAQRILDSLAGATYALGGDKTCIREKLYFFVPKTVKLQAPNNETPSFF
What is the function of this protein?
May act as a cell division protein.
What are the official names of this protein?
Cell division protein sepF homolog.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Plastid, cyanelle.