PharMolix/UniProtQA huggingface dataset:
Protein: DNAK_NEIG1
Sequence: MAKVIGIDLGTTNSCLAISENGQTKVIENAEGARTTPSIIAYLDGGEILVGAPAKRQAVTNAKNTIYAAKRLIGHKFEDKEVQRDIESMPFEIIKADNGDAWVKAQGKELSPPQISAEVLRKMKEAAEAYLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAFGMDKGDNKDRKIAVYDLGGGTFDISIIEIANLDGDKQFEVLATNGDTFLGGEDFDQRLIDYIIDEFKKEQGIDLKQDVMALQRLKEAAEKAKIELSSGQQTEINLPYITMDATGPKHLAMKITRAKFESLVEDLIARSIEPCRTALKDAGLSTGDIDDVILVGGQSRMPKVQEAVKDFFGKEPRKDVNPDEAVAVGAAIQGEVLSGGRSDVLLLDVTPLSLGIETMGGVMTKLIQKNTTIPTKASQVFSTAEDNQSAVTIHVLQGERERASANKSLGQFNLGDIAPAPRGMPQIEVTFDIDANGILHVSAKDKGTGKAANITIQGSSGLSEEEIERMVKDAEANAEEDKKLTELVASRNQAEALIHSVKKSLADYGDKLDAAEKEKIEAALKEAEEAVKGDDKTAIDAKAEALGTASQKLGEMVYAQAQAEAQAGEGAQANASAKKDDDVVDADFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ACKA_BACCZ
Sequence: MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGLEDSIFTITVDGEKQKEITNIPDHAVAVNMLLKKLTENGIVKSLDEIGGIGHRVVHGGEKFADSVLITDEVLADIEELSDLAPLHNPANVVGIKAFQEVLPNVPAVAVFDTAFHQTMPESAFLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLESLSLLSCHLGNGASIAAVEGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPYIMEKTGQTVEEVVNVLNKKSGMLGLTGYSSDLRDIIAKEEEGDHRAKVALDVFVSRIHKYIGSYTARMKGVDAIIFTAGVGENSAIIRERVLEGLEYMGVYFDAKRNNVFGEEAFINFPHSPVKIIVIPTDEEVMIARDVLRLGNIG
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEST2_RAT
Sequence: MIAVLFLAILCLEVDSTAPTPDPSLDVEWNEWRTKHGKTYNMNEERLKRAVWEKNFKMIELHNWEYLEGRHDFTMAMNAFGDLTNIEFVKMMTGFQRQKIKKTHIFQDHQFLYVPKRVDWRQLGYVTPVKNQGHCASSWAFSATGSLEGQMFRKTERLIPLSEQNLLDCMGSNVTHGCSGGFMQYAFQYVKDNGGLATEESYPYRGQGRECRYHAENSAANVRDFVQIPGSEEALMKAVAKVGPISVAVDASHGSFQFYGSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSFWLVKNSWGEEWGMKGYMKLAKDWSNHCGIATYSTYPIV
What are the official names of this protein?
Testin-2, CMB-23.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_HAES1
Sequence: MKIILLGAPGAGKGTQAQFITNKFGIPQISTGDMLRAAIKAGSELGQKAKILMDMGQLVPDDLIISLVKERVAQEDCEKGFLLDGFPRTIPQADALKSVGISIDYVLEFDVPDEVIVERMSGRRVHPASGRTYHIVYNPPKVEDKDDITGEDLILRADDKPETVLDRLKIYHNTTKLLVDYYQAEAAQGNTKYFRLDGTQKVEEVSQELDKILS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_MARMS
Sequence: MAHQQQYIHGRYHASTSGEHFETINPATGEVIATVEHAGQAELDAAVESAKQGQKVWSAMSPVERGRILKKAAELLRENNEELARLEVLDTGKPLQEAIVVDIQTGADVIEYYAGLTDKIQGDYQDLGNGNFFYTRREPLGICAGIGAWNYPIQIAMWKSGPALAAGNAMIFKPSEETPLTALKLAEIFTEAGLPDGVFNVIQGDARTGQLITNHPDIDKVSFTGEVGTGKKVMAASAQSLKQVTMELGGKSPMIIFPDMPVDQAVSAAMLANFYTQGEVCTNGTRVFVHADMLDAFTKELKQRTEAMIIGDPMDMDTQVGALISKDHMQKVLGYIQAAKDAGATLLCGGYQVTENGLDKGAFVAPTVFTDCTDDMPQVRDEIFGPVMSVLSFTDEDEVIARANDTKLGLAAGVFTKDFARAHRVINQLQAGICWINSWGASPAEMPVGGYKQSGIGRENGIETLYHYTQNKSVFVDLNDIQSPY
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ATG17_NEUCR
Sequence: MASFHSHSPSPPAALSPDDAPQPRRPSRTSLHDAAAAAAPALSPESPGHELEDGADSSEFNADDVPVEVLVKHLLAAKQSLSSMTLVLRANDLATSARQMHQEFVILSAQTAFLRHGILQELHILHQLRRGMARAYDNGTRDFKHIIRTLDTADGRLEKIMQVLRKTTVENVFRQPGEEPKCLLDFVDPKIVEQVRDALKESIHELSAAKTSFDGDLLRFDTDLRTLTDAMAAAASLANPTTTTPDGYPPDQRSIPNLLSALSEGSHLMAEHLSSLTRHFDMCVTAVRTTEGGAALARRRAAEATSSDEDQAPVSISGVISAQESESGPSAFEPMDPLERQELLHVVMRDAAEVDDVVADIHNVLQQMEMDHASLHSLFSASRASHAATLTCFSMLEEVGARASSYVAAEAEFMQRWEDEKETIDENVSKMDELKKFYEGFLNAYGGLLLEVERRRAVEGKIDSIWRKAKEQVDKLVEADKREREHFRLEVGDYVPADLWGVVDRPLGRWAVVPLEDTREGSYEMEAHGEPENEGKVETAYERETEPSTPTPRKMPLNGPGSAGERPF
What is the function of this protein?
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation.  Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles.  Plays particularly a role in pexophagy and nucleophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 17.
What is the protein family that this protein belongs to?
Belongs to the ATG17 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: LRC14_HUMAN
Sequence: MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPGASTQPLCRKHALRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLDLSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYGNPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL
What is the function of this protein?
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.
What are the official names of this protein?
Leucine-rich repeat-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the PRAME family. LRRC14 subfamily.
Protein: NU1M_MOUSE
Sequence: MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYGILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGILFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSYSLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MTNN_SALTY
Sequence: MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLASTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: COMB_DEIDV
Sequence: MRLRVDLLPHGNYPDVVVVIDVLRATTTAVAYLERGADALLLTRTPEVALALRPEVGEAGENRPLVLGGERGGLPIPGFDFGNSPVEAAAQNFTGKTVVMNTTNGTDAAHVAAQTGKHILLASLTNAHAAARRARALATEEIAIVCAGTDARVSLEDVYAAGVLAEYLLALGGFSIDDGARIALTMRRNVGNPIEALSSSVHGERLGQLGLGEDVRYAAQVSTSTLVPVLVSGEDVPEGTLKFTAG
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: LIS1_CRYNB
Sequence: MAALSDRQKDELHRAMLAYLHAAGMHNAYAALQHDAALADVDPRDRAVGLLEKKWTSVIRLQKKVIDLENRNAALLAELAAAARPAAPGPFLPRPPPRHTLASHRAPVTRLAFHPTWTLLASASEDATVKLWDWEAGDMERTLKGHTKAVMDVDFDPRGGLMATCSSDLTLKLWDTANQYTNVKTLHGHDHSVSSVRFMPDGETLVSASRDKTIRVWQVSSGYCIKTFSGHAEWVREAVPSEDGRWLVSASNDQTSRIWDFSTGETKMELRGHEHVVECAVFAPVNAYPAIRELAGLKPPAPRDTRAKSPGVYAATGSRDKTIKLWDALSGQCLRTLVGHDNWIRALVFHPSGKYLLSASDDKTIKVWDLANGRCTKTIEAHSHFVTSMTWGRAVGASGGIEKVNGDASSKEPRRINVLATGSVDQTIKVWTP
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  Plays a central role in positioning the mitotic spindle at the bud neck during cell division.  Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles.
Protein: TAGH_STAAS
Sequence: MNVSVNIKNVTKEYRIYRTNKERMKDALIPKHKNKTFFALDDISLKAYEGDVIGLVGINGSGKSTLSNIIGGSLSPTVGKVDRNGEVSVIAISAGLSGQLTGIENIEFKMLCMGFKRKEIKAMTPKIIEFSELGEFIYQPVKKYSSGMRAKLGFSINITVNPDILVIDEALSVGDQTFAQKCLDKIYEFKEQNKTIFFVSHNLGQVRQFCTKIAWIEGGKLKDYGELDDVLPKYEAFLNDFKKKSKAEQKEFRNKLDESRFVIK
What is the function of this protein?
Part of the ABC transporter complex TagGH involved in teichoic acids export.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Teichoic acids export ATP-binding protein TagH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3.A.1.104.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SURE_CAUVC
Sequence: MRILLTNDDGIHAPGLQALEKIARALSDDVWICAPEYEQSGASRALTLADPIRVRKLDSRRFAVEGTPTDCVMMAVQHLIEGGRPDLVLSGVNRGQNIAEDVTLSGTVAGAIEGMAMGIPSIALSQSMNYFHDEIVAHWETAEAFAPGIIQRLLEVGWPADVVMNVNFPALPPESVKAVEVTRQGFRDGHMRHMDKRTDLRGRDYYWMGFTAKASQPAEGTDLRAVYEGRISVTPLHIDLTHNETVHTLKGVLGGAPPRKVGA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_YERPY
Sequence: MSTEHKQSLSAVTLAAIGVVYGDIGTSPLYTLRECFSGHYGFDVRPDVVFGFLSLIFWMLILVVSVKYLTYVMRADNAGEGGILTLMSLAGRNTSSRATSILVVLGLIGGSFFYGEVVITPAISVMSAIEGLEIAAPALDPYIVPCSIAVLTLLFVIQKHGTGSVGKLFAPVMLVWFLTLALLGLRSIIANPEVLAALNPKWAISFFVEYKSVSFFALGAVVLAITGVEALYADMGHFGKFPIRLAWFTVVLPSLVLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLILATLATVIASQAVISGVFSLTRQAVRLGYLPPMRIIHTSEMESGQIYIPVINWTLYLAVVLVIIGFERSSNLAAAYGIAVTGTMVITSILFCTVAWKNWHWNRFLVAFLLMVLLIIDIPMFSANVLKLFSGGWLPLSLGLVMFIIMTTWKSERFSLLRRMHEHSNSLEAMIASLEKSPPVRVPGTAVYMSRAMNVIPFALLHNLKHNKVLHERVVLLTMRTDDVPYVHNVERVTIEQLSPTFWRVVARYGWRETPNVAEIFHRCGLEGLSCQMMETSFFMSHESLILTKRPWHLFLRGKLFIALSRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AC4CH_VIBCH
Sequence: MSISTQITFFEFLTPLVASGQKTITIRDKSESHYVPGTRVEVFTLETQRKVCEIDILAVEPLKFDEINEFHAEQEAIELPKLKALIQEIYPNIDELYVITYQLAK
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: RS14Z_ANAD2
Sequence: MAKLSKMAQATRKLKFPVRQYNRCPLCGRPRAFLRKFQMCRICFRKRALQGEITGVIKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: HIS3_RENSM
Sequence: MPAQISSEDQQLSTKIAERLKRDEAGLVAAVVQQFDSKEVLMLGWMDDEALRRTLRSGRVTFFSRSRQEYWRKGDTSGHIQMVKAVALDCDGDALLISVDQHGPACHTGTRSCFDGRALPAFVEPVFVEPVA
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCXA_BUTOM
Sequence: VRDAYIAQNYNCVYDCARDAYCNDLCTKNGAKSGYCEWFGPHGDACWCIDLPNNVPIKVEGKCHRK
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Toxin Boma6a, Alpha-neurotoxin Bom alpha-6a.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TDH_PECCP
Sequence: MKALAKLRPEEGIWMVDSPTPELGHNDIMIKIRKSAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEIVAIGQEVNGFHIGDRVSGEGHITCGYCRNCRAGRRHLCRNAIGVGVNRPGSFAEYLVIPAYNAFRIPDNISDELAAIFDPFGNAVHTALSFDLVGEDVLIAGAGPIGMMAAAVCRHVGARNVVITDVNAYRLDLARKMGATRAVNVAEERLADVMIELGMTEGFDIGLEMSGAPSAFRAMLKAMNHGGRIAMLGIPHEPMSIDWGEVIFKGLFIKGIYGREMFETWYKMSALIQSGLDLSPIITHRFHIDEFQKGFDAMRSGQSGKVILNWDER
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHRL_CANLF
Sequence: MPSLGTMCSLLLFSVLWVDLAMAGSSFLSPEHQKLQQRKESKKPPAKLQPRALEGSLGPEDTSQVEEAEDELEIRFNAPFDVGIKLSGPQYHQHGQALGKFLQEVLWEDTNEALADE
What is the function of this protein?
Obestatin may be the ligand for GPR39.  May have an appetite-reducing effect resulting in decreased food intake.  May reduce gastric emptying activity and jejunal motility (By similarity).
What are the official names of this protein?
Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: P53_XENLA
Sequence: MEPSSETGMDPPLSQETFEDLWSLLPDPLQTVTCRLDNLSEFPDYPLAADMTVLQEGLMGNAVPTVTSCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACPGRDRRTEEDNYTKKRGLKPSGKRELAHPPSSEPPLPKKRLVVVDDDEEIFTLRIKGRSRYEMIKKLNDALELQESLDQQKVTIKCRKCRDEIKPKKGKKLLVKDEQPDSE
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VKTH7_BUNMU
Sequence: RQRHPDCDKPPDTKRCTGHNPAFYYNPRRKNCERFSYGGCGGNGNHFKTKQLCHCHCHEND
What is the function of this protein?
Beta-bungarotoxins are presynaptic neurotoxins of the venom.  The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and blocks voltage-gated potassium channels (Kv) (By similarity).
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B5-B chain, Beta-bungarotoxin B5 chain.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARAA_HERA2
Sequence: MLDLKQYEVWFITGSQHLYGPETLEQVAKHSQIIAAGLDQSSTIPVRVVFKPVLKTPDEIYNLVLEANAAKNCIGLVAWMHTFSPAKMWIAGLRSLQKPLAHLHTQFNSEIPWSEIDMDFMNLNQAAHGDREFGFIVSRMRLERKVIVGHWQDSEVHDRIAAWTRAAAAWHDAQGARFARFGDNMREVAVTEGDKVNAQMRLGYSVSGYGVGDLVRFVNEVSDADIDSTLQEYAEQYELAAGLQAGGEQHHSLREAARIELGLRYFLEHGNFKGFTTTFEDLHGLVQLPGLGPQRLMDRGYGFAGEGDWKTAALVRAMKVMSAGLNGGTSFMEDYTYHFGSNGMKVLGAHMLEICPSIAATKPRLEVHPLGIGGKADPVRMVFDAKTGPAVNASIVEMGNRLRLINSVVDAVETDQPLPKLPVARALWLPQPDLKTAAAAWIYAGGAHHTGFSFDLTSEHLADFAEIAGMEYLQIDRNTNVQQFKQELRWNDLYYHLAKGL
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: TRPA_CALS8
Sequence: MNLIDKKFEELKIKGKKAFIGYTTFGYPTKGETLDYIKLIYSYVDVLELGFPFSDPIADGEVIQRASVKALKEDIKLDHLFYSIEKFKKDKPIAIMLYANTVYKRGIEKFFKDCKDFGADAVIIPDISYEESAEFKAACRENGVHYIDLISISSIERAKMIAKTSKGFVYCVTRKGVTGFKGEIDKSIYELLSELKKVTSTPLAVGFGIKSKEDVLKLKEVADGIVIGSAIINKIDEGKEDLVSFLETIRSVL
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: ARPC2_MOUSE
Sequence: MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPEPGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNATARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
What is the function of this protein?
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility.  Seems to contact the mother actin filament.  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Synapse, synaptosome. Nucleus.
Protein: CSTP1_MACFA
Sequence: MLSPERLALPDYEYLAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFWRCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVIVPTSSSGQHRQRPALGEAGMLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHHGINQALGALPDKGDLMHDPAMDEELERLLAQVPGLVNSITASPEASCLPSRTPPRVGSPWRPLHHSRKVDGESDGSTEETDESET
What is the function of this protein?
Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly.  Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
What are the official names of this protein?
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1.
What is the protein family that this protein belongs to?
Belongs to the CSTPP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Protein: AROQ_RHOP5
Sequence: MPKTIYVLNGPNLNLLGTREPDVYGHATLADVERLCAETASGYGLAVDCRQSNHEGDLIDFIHDARATGAIGIVINPGGYTHTSIALHDALAAVQIPAVEVHVSNIHARESFRQHSFTAKAAFASLCGFGIDGYRLAISGLAAKLGITAKA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: QUEA_VIBVY
Sequence: MQVSDFHFDLPDELIARYPQSERTASRLLQLNGNTGAVKDGSFKDVLELVQAGDLVVFNNTRVIPARMFGRKESGGKLEVLVERMLDEKRFLAHVRSSKSPKPGTLVFLGEEDQYSAEMVARQDALFELHLKADKTILEVLEEIGHMPLPPYIDRPDEDADKERYQTVYNQKPGAVAAPTAGLHFDNQLLEQIKAKGAEFAYVTLHVGAGTFQPVKVDNILEHHMHSEYAEVPQEVVDAIKATKARGGRVIAVGTTSVRSLESAAQESLKNGTELMPFFGDTEIFIFPGYQYQLVDCLITNFHLPESTLIMLVSAFAGYDHTMNAYQHAVANQYRFFSYGDAMFIEKKTQ
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_BREBN
Sequence: MHVKKGDTVIVNAGKDKGKKGRVLAAYPKKERVLVEGINLVKKHSRPSQANPQGGIVTQEAAIHVSNVSLIDPKSGKATRIGYKVLDNGKKVRYAKKSGEVLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.