PharMolix/UniProtQA huggingface dataset:
Protein: IGM_HUMAN
Sequence: QVTLTESGPALVKPKQPLTLTCTFSGFSLSTSRMRVSWIRRPPGKALEWLARIDDDDKFYWSTSLRTRLSISKNDSKNQVVLIMINVNPVDTATYYCARVVNSVMAGYYYYYMDVWGKGTTVTVSSGSASAPTLFPLVSCENSNPSSTVAVGCLAQDFLPDSITFSWKYNQSQKISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVCKWVQHPNGNKQKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQVWSLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGESMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTREENGAVKTHTNISESHPNATFSAVGEASICEDDDWSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGEPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGQTYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY
What is the function of this protein?
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).  IgM antibodies play an important role in primary defense mechanisms.  They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions.  The membrane-bound form is found in the majority of normal B cells alongside with IgD.  Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases.  It may cause death of cells by apoptosis.  It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer.  After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (, PubMed:16895553).
What are the official names of this protein?
Immunoglobulin mu heavy chain, Immunoglobulin mu heavy chain OU.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: GLGA_HAEIN
Sequence: MKILHVCSELYPLLKTGGLADVLGALPQAQNQIGLDARFLLPAYPAITTGIPNTQVVAEFDNFAGHVVLRYGEYNGVGIYLIDAPHLYGREGNPYHDAYYNDYGDNYKRFALLGWVGAELATGLDSWWRAEVVHAHDWHAGLCVAYLFNKGKPAKSVFTIHNLAYQGQFSYHHLYEIGLPTGMFHVEGLELFGQISYLKSGLFYSDASTAVSPTYAQEITTPEFAYGLQGLLSGLKAQGRLVGILNGVDENIWHPNVDQYIPHHYKLKYMAGKKKNKAELQAYFNLPQDESALAFVMVTRLTEQKGVDLLIESADEIVKQGGQLMILGSGAPHLEQGIRELAERYPQNIAVKIGYDEALSHLMVAGGDVILVPSRFEPCGLTQLYGLQYGTLPLVRKTGGLADTVVDSTSESIKARTATGFVFESATPEALRHCLQRAFALWQKPRAWAMVRTDAMEQDFSWRKAAEQYRTLYERL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RAC6_ARATH
Sequence: MSASRFIKCVTVGDGAVGKTCLLISYTSNTFPTDYVPTVFDNFSANVVVNGATVNLGLWDTAGQEDYNRLRPLSYRGADVFILAFSLISKASYENVSKKWIPELKHYAPGVPIVLVGTKLDLRDDKQFFIDHPGAVPITTVQGEELKKLIGAPAYIECSSKSQENVKGVFDAAIRVVLQPPKQKKKKNKAQKACSIL
What is the function of this protein?
Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.
What are the official names of this protein?
Rac-like GTP-binding protein ARAC6, GTPase protein ROP5.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with the membrane when activated.
Protein: Y2292_SHESA
Sequence: MIFYLHGFDATSPGNHEKMRQLQFIDPDVRLISYSTLHPKHDMQHLLKEVAKQMQYCADPAPLMVGVGLGAYWAERIGFLNGLKSVLINPNLHPEETMQGKIDRPEEYADIANKCVSEFRLKNTHRAMCILSRVDEVLDSEATAEALKPYYTIEWDETQAHKFPQLAAHLPKIKAFKLS
What are the official names of this protein?
UPF0227 protein Shewana3_2292.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: DEOB_SALEP
Sequence: MKRAFIMVLDSFGIGATEDADRFGDVGSDTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLVKAHEGSTGKIAAGMDGNADVIGAYAWAHELSSGKDTPSGHWEIAGVPVLFDWGYFSDHENSFPQELLDKLVKRANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTEGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKQGHVVSVGKIADIYANCGITKKVKATGLDALFDATLKEMKEAGDKTIVFTNFVDFDSSWGHRRDIAGYAAGLELFDRRLPELMELVGEDDILILTADHGCDPSWTGTDHTREHIPVLIYGPKVKPGSLGHRETFADIGQTLATYFGTSPMDYGKNML
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR468_MIMIV
Sequence: MEDLVCVSNHNICIHISVNILFIDIYITILMSKQESDNVFWIYDPMILFRDGNYLKIFPTKDMTQIQVLNALTRLCIYLAIIFVLVSAISGYAYVPIIFILIIIVIYFFNNNKNSVQTEMFDDNYPNTNNSDNIDNTDNIMNKQNYKKISDYNPYMNLTLNDIGSGNDDLEANLVELPKDSNRKFYTTSSTTNPNKQEDFMKWIYDLPETCKENQACCLRHEDVRFKRHNPDIDSPTPNS
What are the official names of this protein?
Uncharacterized protein R468.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HSP1_SMILE
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: U2QL1_DROME
Sequence: MSSRSKERVVTAFRKIFHKSSNNNNNNNNNHNNNINNNNNNDKVDGATGSSPNINNNNNNNNNNNNHDGAAAPSSAGGVAVAGGAVGSSGSSGAAKNAVVRMAAEQAVWDSPGKRRRQDHKVAPTTERQLVAAPDHTIRTRRLMKEYREMERLQAKNDAVFTVELVNDSLFEWHVRLHVIDPDSPLARDMAEMGVPAILLHLSFPDNFPFAPPFMRVVEPHIEKGYVMEGGAICMELLTPRGWASAYTVEAVIMQFAASVVKGQGRIARKPKSTKEFTRRQAEESFRSLVKTHEKYGWVTPALSDG
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2Q-like protein CG4502, E2Q-like ubiquitin-conjugating enzyme CG4502.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: RL5_HELHP
Sequence: MFALREKYKNEIISQLKSELNMSNPMLLPKLEKIVISVGAGDYAKDSKIMQNIADTISLIAGQKAVITLAKKSVAGFKMREGMPMGVKVTLRGKMMYNFLEKLIVIALPRVKDFRGLKRNGFDGRGNYSFGLNEQLMFPEVVYDDIMVTHGMNITIVTSTHSDKEAFKLLELLGMPFAKGR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y482_METM7
Sequence: MKFFQEKISIKETNILLKVDNPKFFKIAKNTIINERFNLENYILRNPIFLTSYSPVEVLDNAPKIVKLMAEAGFNADVGPMAAVAGTFSQLIVENLIENDCKNAISENGGDICLKCEMDTTVGLYAGNSSLSGSLGFKLKKEKIKNGYGICTSSGTVGHSVSLGNADSVTVFSKSASIADAAATSIGNFAVGNNVDAINKCLEKAENIPKIDGVFVCMGEHAGKIGKIPQFIKTDKKEGLGNVFEMF
What are the official names of this protein?
UPF0280 protein MmarC7_0482.
What is the protein family that this protein belongs to?
Belongs to the UPF0280 family.
Protein: OPA66_NEIGO
Sequence: AGEGNGRGPYVQADLAYAYEHITHDYPKPTDPSKGKLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNDSKYSVSIKNLQRRTSNGNRRDRKTENQENGSFHAVSSLGLSAVYDFKLNDKFKPYIGARVAYGHVRHSIDSTKKTTEFLTTAGARGTDPTVSSPYKNTQDAHQESNSIRRVGLGVIAGVGFDITPNLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
What is the function of this protein?
Implicated in a number of adherence functions.  OPA proteins are implicated in pathogenesis and are subject to phase variation.
What are the official names of this protein?
Opacity protein opA66.
What is the protein family that this protein belongs to?
Belongs to the opacity porin family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RNF17_MACFA
Sequence: MAAEPSKTGPSRSAYQRMGRKSQHWGAADIQCTRCGRRVSRASGHHCELQCGHAFCELCLLMTEECTTIVCPDCEVATAVNTRQGCYAMAGYVKEDSVMEKRQPKTIKNCSQDFKKTADQLTTGLERSASTHRTVLNSSSVMLDTNTAEEIDEALTTAHHNFEQLSIAGKALEHMQKQTIEERERVTEVVEKQFDQLLAFFDSRKKKYNNKKGLSCYDTYPPLEKKKVDMSVVTNEAPPPPLQPETNDVHLEAKIFQPQKDVVATASSKTIAVLPQMGSSPDVIIEEIIEDNMETCSTDDLGETPRYPKKPLQKNSSVPFGSKAGSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIFVNSIKNGMWCRGTITELIPIEGKNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHSAKQHIALNDLCLILRKSEPYIEGLLKDIQPLAQPCSLKDIVPQNSNEGWEEEAKVEFLKMVNNKAVSMKVFREEDGVLIVDLQKPPPNKISSDMPVSLRDALVFMELAKFKSQSLRSHFEKNTTLHYHPPILPKEMTDVSVTVCHINSPGDFYLQLIEGLDFLFLLKTIEEFYKNEAGENLEILCPVQDQVCVAKFEDGIWYRAKVIGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLTAPEKAIKCKLAYIEPYKRTMQWSKEAKEKFEDKAQDKFMTCSIIKILEDNVLLVELFDSLGVPEMTTTSINDQLVKEGLASYEIGYILKDNSQKHIEVWDPSPEEIISNEVHNLNPVSAKSLPNENFQSLYNKELPVHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLQENLKTMGRLSLECSLVDIRPAGGSDKWTATACDCLSLYLTGAVATIILQVDSEENNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRERRINKLDNSHSLSEKSLEVPLEQEDSVVTNCIKTNFDPDKKTADIISEQKVSEFQEEILEPRTARGYKPPAIPNMKVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQLLSKREVDIHIMELPKNPWEKLSIHLYFDGMSLSYFMAYYKYCTSEHTEEMLKEKPRSDHDRKYEEEQWEIRFEELLSSETDTPLLPPYLSSSLPSPGELCAVQVKHVVSPNEVYICLDSIETCNHSNQHSDTDDSGVSGESESESLDEALQRVNKKVEALPPLTDFRTEMPCLAEYDDGLWYRAKIVSIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPPHLMRYPARAIKVLLAGFKPPLRDLGETRIPYCPKWSMEALWAMIDCLQGKQLYAVSMAPAPEQIVTLYDEEQHPVHMPLVEMGLADKDE
What is the function of this protein?
Seems to be involved in regulation of transcriptional activity of MYC.  In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers.  Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm.  May be involved in spermiogenesis (By similarity).
What are the official names of this protein?
RING finger protein 17.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity).
Protein: RLMKL_YERP3
Sequence: MNSLFASTARGLEELLKSELEALGAHDCKIVQGGVHFQGDDRLMYQSLLWSRLASRILLPLNEFKVYSDLDLYLGVQAIDWPSIFGVDKTFAVHFSGVNDEIRNSQYGALKVKDAIVDSFTRKMDQRPTVAKQQPDIRVNVFLQRDMASVALDLSGEGLHQRGYRDLTGQAPLKENLAAAIIQRSGWQPGTPMVDPMCGSGTLLIEAAMMASDRAPGLHRGHWGFTAWNAFNEALWRELTTEAQVRARRGLLETSSRFFGSDIDRRVIEMARANARRAGVAELITFNANDISKLVNPLPEGPVGTVISNPPYGERLESEPALIALHNMFGRMMKTAFGGWRLSLFSASPELLSCLQLRADREFKAKNGPLDCVQKNYQLTANPQGAGGALVAEDYANRLRKNVKKLDKWAKQQGIECYRLYDADLPDYNVAVDRYGSKVVVQEYAPPKTIDPQKARQRLFDVINATLAVLELPSNQLVLKTRERQKGKNQYEKLAQKGEFLLVSEYNAKLWVNLTDYLDTGLFLDHRIARQMLGKMSQGKDFLNLFAYTGTASVHAGLGGARSTTTVDMSRTYLEWAEKNLRANGLTGQQHRLIQADCLSWLSNTDEQFDVIFIDPPTFSNSKRMETTFDVQRDHLVLMKELKRLLRRKGTIMFSNNKRGFQMDLAGIAALGLEAKEITALTQSEDFARNRQIHNCWLVTHSQEEK
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B2CL2_MOUSE
Sequence: MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
What is the function of this protein?
Promotes cell survival.  Blocks dexamethasone-induced apoptosis.  Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
What are the official names of this protein?
Bcl-2-like protein 2, Bcl2-L-2, Apoptosis regulator Bcl-W, c98.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane (By similarity).
Protein: RUVA_SHIB3
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDASSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: YNZG_BACSU
Sequence: MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKSAVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS
What are the official names of this protein?
UPF0457 protein YnzG.
What is the protein family that this protein belongs to?
Belongs to the UPF0457 family.
Protein: ASSY_ECO7I
Sequence: MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAD27_ORYSJ
Sequence: MGRGKIVIRRIDNSTSRQVTFSKRRNGIFKKAKELAILCDAEVGLMIFSSTGRLYEYSSTSMKSVIDRYGKSKDEQQAVANPNSELKFWQREAASLRQQLHNLQENHRQLMGEDLSGLNVKELQSLENQLEISLRSVRTKKDHVLIDEIHELNRKGSLVHQENMELYKKISLIRQENAELYKKIYETEGPSEVNRDSPTPYNFAVIEKTNVPVQLGLSTLPQHSDAEQSTAPKLGLQLNP
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
MADS-box transcription factor 27, OsMADS27, RMADS218.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL17_FRATO
Sequence: MRHRKQGRKFGRTSSHRKAMFKNMSASLINHELIKTTLPKAKELRTIVEPLVTLAKREHKLRQELDTNSNEFKAQSVALRRQAFDFLRNKAAVTKLFEEFGARYAERAGGYTRILKCGYRFGDKAPMAFIELVDRPQVEEAADEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: LNT_BORBU
Sequence: MKTRCFCLAAFSGILTTLAIPNEIKETGYSILGFVAYVPLFIALNKLEDKKALMGLTVFYFIIANSLQNFWLGFFHAFGWITFIGVIIGYIPYSLTLGYFLYYSLKSFKNKTMSITMLFTFYDYSRSIGFLAYPWGLAAFTVNNFNNLIQIADIFGVFFVSFAVYFLNSGIADFLIHKNKTNLLNIAFPTLLITASFTYGMIKKIELKNLLAKEIDSLNIAAIQLNTDPWLPGNDKKGIRDSIEITEQALKENPKIEFVIWSEGVLTYPFSKEDQHFKSSDLHNELKNFIKEHKIPFAIGAPSNLDKAIGIQQNSIYMVEPNLNITNIYSKIFLVPFAEKIPFYEYKFVRNFFLKNFRILGQIEGNKIEILKLKKFKFAPLICYDDAFPELSRFYKTQGANILVNFSNDSWSKTNSAEWQHFVVAKFRSIENGIKTIRATNSGITATINEYGETIKKLETFKKGYLLSTVKLSPTFTTIYEKIGDSFIHILVMMFLITTLRFQFMEDKNQLLSSSVVKIKV
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18_BARHE
Sequence: MVSSKDIIQRRARRVRRRIKMVSGNRLRLSIYRSNQNIYAQIIDDLRGCTLVSASTLDGDLKKSLKSGSDKEAAFAVGKLIAERAKKAGVNEVVFDRGAYVYHGRVKALAEAAREGGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PLSY_BACSU
Sequence: MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNAFRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGGKAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYLLIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBQ_SYNJB
Sequence: MSCSGRSLMVVGTSSHVGKTLLVTALCRILKKAGKRVAPFKAQNMSLNAYVTPDGKEIAYAQALQAWAAGIPPAVEMNPILLKPQGNLTSQIVLNGVAVGTYRAGEYYERWFAPAWQAVKEALARLQKQYDWILCEGAGSPAEVNLKHRDLANMRVALHLGSPTWLVADIDRGGALAHVVGTLQLLEPEERALIRGIVINKFRGSRELLQPGLDWLENYTGIPVVGVLPWVDWVLPQEDSMGIAANPLLWEDRRDRAGGQALREGRLEIAVVRLPQVANFSDFDPLLAEPTVHLRWVHPGQSLGSPDVVILPGSKTTLNDLFALQKTGLAEQLRQYSGHIVGICGGLQMLGETIADPEGWEGIAGTYSGLGFLPLTTVLQPTKVTQQVQTQSRWPALAPIQGYEIHQGSTQADPSGCLPLFDRENLGWRDPTGRIWGSYLHGLFDNHLWRRQWLNWLRRQKGWDPLPELEGHYAQQREQLLERLADLWQPHLDLGLLME
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: YHAM_GEOSW
Sequence: MAKGIVHYEVGEQVDVYLLIKSVTKGIASNGKPFLTLILQDKTGDIEAKLWDVSPEDESVYVPESIVKVLGDIHNYRGKMQLKIRSIRLAHEGDAVRVSDFLETAPMKREDMMEKITEYIFAMQNPNIQRITRYLLKKYEQKFFDYPAATKNHHEFISGLAYHVVSMLELAKALVNLYPSLNRDLLYAGVILHDLGKVIELSGPVSASYTLEGKLLGHIPIMVGEISKAAEHLGISGEEIVVLQHMVLSHHGKAEWGSPKPPMVKEAEILHYIDNLDAKMNMIDRALEKVKPGEFTERIYALENRSFYKPIFSSVLMQERGGTS
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: GLYAT_PONAB
Sequence: MMLPLQGAQMLQVLEKSLRRSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCPQEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAVIKSFKVKQTQRILYMAAETAKELAPFLLKSKILSPSGGKPKAINQEMFKLSSMDVTHAQLVSKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLHGLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL
What is the function of this protein?
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently.  Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
What are the official names of this protein?
Glycine N-acyltransferase, Acyl-CoA:glycine N-acyltransferase, AAc, Aralkyl acyl-CoA N-acyltransferase, Aralkyl acyl-CoA:amino acid N-acyltransferase, Benzoyl-coenzyme A:glycine N-acyltransferase, Glycine N-benzoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycine N-acyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CYTM1_HUMAN
Sequence: MNQENPPPYPGPGPTAPYPPYPPQPMGPGPMGGPYPPPQGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDELGPSTCLTACWTALCCCCLWDMLT
What are the official names of this protein?
Cysteine-rich and transmembrane domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CYSTM1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PA_I96A3
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVEPEDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDSLKLSIEDPNHEGEGIPLYDAIKCMRTFFGWKEPSVVKPHGKGINPNYLLSWKQVLAELQDIESEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDDCKDISDLKQYDSDEPELRSFSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIVKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENRSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.