PharMolix/UniProtQA huggingface dataset:
Protein: ISG15_HUMAN
Sequence: MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTEPGGRS
What is the function of this protein?
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein.  ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein (PubMed:33727702).  Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6.  Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses (PubMed:33727702).  Can also isgylate: EIF2AK2/PKR which results in its activation, RIGI which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling.  Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus.  Restricts HIV-1 and ebola virus via disruption of viral budding.  Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells.  Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40.  ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication.  The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity.  The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055).
What are the official names of this protein?
Ubiquitin-like protein ISG15, Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, IP17, Ubiquitin cross-reactive protein, hUCRP.
Protein: GUAA_LACAC
Sequence: MAKNLEDFDKIIVLDFGSQYNQLITRRIRDFGIYSELLPHDLSIEKIKEMNPKGIIFSGGPNSVYDDGALKVDPEIFKLGIPILGICYGMQLMSYDLGGKVERAENKEYGRANITVEDPDSALFKGLPTKQYVWMSHGDLVTQAPEGFEVTASSKNCPIAAIANPDKKFYGIQFHAEVRNSEYGLDILKHFAFDVCGAVANWTMADFIDMQVDEIRKEVGDKKVILGLSGGVDSSVTATLLHKAIGDQLTAIFVDHGMLRKDEGDQVMKALNKDLGVNIIRVNAQERFLNKLKGVTDPEQKRKIIGKEFIEVFNEEAKKLKDVDFLAQGTLYTDVIESGTNTAQTIKSHHNVGGLPEDMNFKLIEPLRKLFKDEVRELGEKLGIPHDLVWRQPFPGPGLGIRVLGEVTEDKLKIVRESDAILREEIKKAGLQEKIWQYFTVLPGIRSVGVMGDGRTYDYTIGIRAVTSIDGMTADFAQIPWDVLGHISDRIVNEVDNVNRIVYDVTSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: LEO1_PONAB
Sequence: MADMEDLFGSDADSEAERRDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKVHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDGEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEEDD
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  Involved in polyadenylation of mRNA precursors.  Connects PAF1C to Wnt signaling (By similarity).
What are the official names of this protein?
RNA polymerase-associated protein LEO1.
What is the protein family that this protein belongs to?
Belongs to the LEO1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_STRPI
Sequence: MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGIKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYISEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYILITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGAGNPEAISNRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQIAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVASLILTTEAVVANKPEPVAPAPAMDPSMMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_PHOVI
Sequence: MFMINIISLIIPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYGLLQPIADAVKLFTKEPLRPLTSSTTMFIMAPILALALALTMWVPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMNGSFTLSTLIITQEHLWLIFPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFLAEYANIIMMNIFTTLLFFGAFHNPYMPELYVINFTVKTLALTILFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVTLPITSASIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS11_GLUOX
Sequence: MAKAAAPRIRKKERKNIISGVAHVLSTFNNTMITISDAQGNAIAWSSSGAQGFKGSRKSTPYAAQVAAEDAGRKAREHGMETLEIEVSGPGSGRESALRALQAVGFNITSIRDMTPVPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: H4_ASPFU
Sequence: MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: AMZA_SULIL
Sequence: MTEMKILIVTLTYIEKSIIDEIVNNLSSYGLEVDILFDSRKYLPISAFNWERLQYDAEKVLSFLKSKYDFNYDSIIFLADSDGYIDGYNFVFGLTIDNFAIIFLNRLREEFYNRKPDLELFMKRVVKEVTHEAGHTLGLGHCNTIGCVMNFSNTVEDVDKKQARFCKNCIYKIENLSKYLQRK
What is the function of this protein?
Probable zinc metalloprotease whose natural substrate is unknown.
What are the official names of this protein?
Archaemetzincin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M54 family.
Protein: LACG_STRP3
Sequence: MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECHKRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKYPFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDFAALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDVPKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVKKHLEVISDAISDGVNVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKKVAETQVIE
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: KDSA_RICCK
Sequence: MQKVVKLHNIKIGNDLPFILIAGPCQIEGQDHALFMAEKLVKLTSKLDIPFIYKSSFDKANRTSINGVRGLGIEKGLEVLSKVKAEFDCPIVTDVHSESQCTETARVVDILQIPAFLCRQTDLLQAAAKTGKIVKVKKGQFLAPWDMKNVQTKLKAFGAENILFTERGTCFGYNNLVSDMRSLAIMAKLNVPVIFDATHSVQQPGGLGDSTGGERKYVELLAKAATTVGIAGMYMEVHQDPDNAPSDGPCMIKLDNLESILIKLKKYDKITKEK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLEE_ECO27
Sequence: MINPVTNTQGVSPINTKYAEHVVKNIYPKIKHDYFNESPNIYDKKYISGITRGVAELKQEEFVNEKARRFSYMKTMYSVCPEAFEPISRNEASTPEGSWLTVISGKRPMGQFSVDSLYNPDLHALCELPDICCKIFPKENNDFLYIVVVYRNDSPLGEQRANRFIELYNIKRDIMQELNYELPELKAVKSEMIIAREMGEIFSYMPGEIDSYMKYINNKLSKIE
What is the function of this protein?
Cysteine methyltransferase effector that inhibits host cell NF-kappa-B activation by preventing nuclear translocation of host protein RELA/p65 (PubMed:20126447, PubMed:20485572, PubMed:22158122, PubMed:25412445, PubMed:27445336).  Acts by mediating cysteine methylation of host proteins TAB2 and TAB3: methylation of a conserved cysteine residue of the RanBP2-type zinc finger (NZF) of TAB2 and TAB3 disrupts zinc-binding, thereby inactivating the ubiquitin chain-binding activity of TAB2 and TAB3, leading to NF-kappa-B inactivation (PubMed:22158122, PubMed:25412445, PubMed:27445336).  Also mediates cysteine methylation of host protein ZRANB3, inactivating its ability to bind ubiquitin chains (PubMed:25412445).
What are the official names of this protein?
Cysteine S-methyltransferase NleE, Effector protein NleE, Non-LEE-encoded type III effector E.
What is the protein family that this protein belongs to?
Belongs to the NleE/OspZ family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Secreted via the type III secretion system (TTSS) (PubMed:17984206). Localizes in the nucleus of the infected cells (PubMed:17984206).
Protein: Y1050_PYRFU
Sequence: MLNVTKGKEIRIEVRFADNFIKRFLGLMFRKPRYVLIFVLPLETRINASVHGLFMREAIDVIFLNSNKEVVDLTVLKPWRFYVPKRPAKYIVEGPRGIIEALSVEVGDRLEWNRMI
What are the official names of this protein?
UPF0127 protein PF1050.
What is the protein family that this protein belongs to?
Belongs to the UPF0127 family.
Protein: Y3337_DICDI
Sequence: MENNNNNNINKTNTPNNSFSPIKNRIEHFERMSSSPNISIPLSQKEYYCSPKKNISLNNINHNINYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCIVGESNIINNNKDDYNSNNNSTINYNIVRESNSNNNSNNSNININNNSNNNFEKEKIIENNKEYINSDFDSISNNDNNNYNNNNIFIFEKIEYNKEEIDCVIAINSDIESNKNDENDDNYKNHNYEIIIVGENNNSKEDCNSSNNSYDNDSNSNSDISTSVNCNSINNNDTIDKNNSTNIIKSIENNNKNNYNKNNNKNNIKSIFENILIKVFTIIDKESSKLIQGLKIENKLKSQLSYLEEDYIYQTVLAILQTKVLQVIFNDVFPNSNIYNDNENNNNNNNNNNNNNNNNNNNNNNINNYIVEESNNNISVIDNNNNSDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKSNNYIVEESNNNSVIDNNNSVIDNNNNINNNSNNNNNNNNNNNNNNNNSEQNFTYNEKKIQNPIIRCIRNLREIRIKKIPKNIHVDLFQDYRNIQIIHNQFPELFTDSINDCYKIFHHFCLTYSGPDVKQFLCEFSKIGVISCSDENENSSLYYAIENKVNGLQLVCEMVCNGLINIEMAKKTNKHGHSILCKCINLKNIPILKLLISFGFDHFEICQNCKNTDQDIQDIFDDIYFSMAYFSTIPDSVNGKLIKTNIALLTELIYSQEKLKLLFKVANAPVPTEIEKAVNKFIFKMDDYKTKYNLKKNEIESIEKVGIIDKSQLSDFSIIGEGGFSTVHKATYINLQNTITPVAIKSFKNYDDDSFERIYKEVSVHQSLQGENILKLIGVSKLKFGLSIIIEKCDMDLKNFISCNQINLDLFFILSTQMVNSVSQVHNHYPEAEINVYHRDIKLENWLIKTIDGNHTVFISDFGLSRSNTESNGCTLQQIRGTNLHIAPECYKGFLFSSQSDIFSVGISLYQLAYKLVYGKFVHPYHEYQIADEPENLNIIQNTGLIPTIPPNLPSRLKRLLFLMMSKMPERRPSIKECIEEIQKCKEEYESDRTKWDTEISVHEDYSLLNEQMINQYHYIKSDVLDYIRDFDLNQNPHDNYVQELESFDYSSYFIKCKSFNEDR
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0283337.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: C149B_DANRE
Sequence: MANQLRERHQGLKKKYRELIDGDPSLPPEKRNQVNLAQLLRDSREHNKQLSEELKELKQRLAEVHGDNKLLRMTIAKQRLGDEEVGTRHFPAHEREDLVQQLERAREQTEALEQSLKAATDELQDVRAERNVYQEKAHRLNLEINHILGSHENRILDIDALCMENRYLHERLMQLQEEVSLLKSNVMKYKSALESKKNCKVYGKSNSSALTGVLSAKQVQELLLSEENGCSLPVTSQSISDLKSLATALLETIHEKNMVIRHQRQTNKILGNRVAELERKLKTLEVSGLWSLPGITYNVSLGLGRRKAVIVLSDSQHVQSTTEQSVHLTPEAMVADEEIVTGEEVTEDTGLSADFSQDECQAGAVELNQNSDYFTHTYSVSATPQVSTPAENIQPVESMQSKTLALCDSERSACTAERSEQHDEDLQSGGHQSMSTEASLKALEEQAVENDNFSGDCESQGALEDSQPVTSETSGSFDCISGSESCTAEQQTERSIEEETEHASLNTSPPEQTSPHQECPSS
What are the official names of this protein?
Coiled-coil domain-containing protein 149-B.
What is the protein family that this protein belongs to?
Belongs to the CCDC149 family.
Protein: HIS6_DESVV
Sequence: MLSKRIIPCLDVRAGRLTKGVKFEGNVDIGDPVATARRYYEEGADEIVFYDITASHEDRGIFLDVVERVASEIFIPFSVGGGINTVDDMRAVLMAGAEKVSVNSGAVKTPDIISQGAAAFGSQAIVVGMDVKQVEKSATIPSGYEIVIHGGRKYMGMDAIEWAKTCESLGAGELCVNSIDADGTKDGYELTLTRMISDAVTIPVIASGGAGSPEHMYDALTRGGASAALIASIVHYGTYTIPDLKRRISGMGAKMRMVW
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_LEPBP
Sequence: MIITVCKGKIHRAVVTEAELHYEGSLTVDQDLMDMAGMKPYEQVSVVNVNNGARFETYLIVGERGSGTICLNGAAARLGMKGDKVIIITYGQVEEKDLPNDYQPKVVFVDENNRPKKA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLY18_SOLLC
Sequence: MSTLFFTFSLLLLAPLLVISSIQDPELVVQDVHRSINASLTRRNLGYLSCGSGNPIDRLLAMQPQLGKKSPAFSYCAIGFGKNAIGGKNGRIYVVTDSGNDDPVNPKPGTLRHAVIQDEPLWIIFKRDMVIQLKQELVMNSYKTIDGRGASVHISGGPCITIHHTSNIIIHGINIHDCKQSGNGNIRDSPNHSGWWDVSDGDGISIFGGKNIWVDHCSLSNCHDGLIDAIHGSTAITISNNYFTHHDKVMLLGHSDSFTQDKGMQVTVAFNHFGEGLVQRMPRCRHGYFHVVNNDYTHWEMYAIGGSAAPTINSQGNRFLAPNEKYRKEVTKHEDAPESQWRSWNWRSEGDLMLNGAYFRQTGAGASSSSTYARASSLSARPSSLVGSITTNAGPVNCKKGSRC
What is the function of this protein?
May have a role in the development of the transmitting tissue of the style and/or in the events related to pollination such as some aspect in the facilitation of compatible pollen tube growth.
What are the official names of this protein?
Probable pectate lyase P18, Style development-specific protein 9612.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IRS4_SCHPO
Sequence: MDAIHPVSLRNSKRHPLLHSERNLSRRAVSPSISRSFFQHSNGSFPLFQNHRKSLPSAIYKSVDPYVDANPLDPLAAAKASFADFPEQDDSQSSTSPLSSKYHTKKNKQIFVEDSRRGGAASNAAAIAAKKSGYYERTSTRKRSLTVPTPRTSFPHHPRSRRFSLKNAAIATSYHKFKPLSSNSLSSSGMHFSASKQAFNSPLLQTFSPSPSVSPFSNPAVEKLKTSASKQAAEAQSLREFDFFTPTPEPSDKNLEKLKNGASKQASESQSLKNMESLSLARSSPILTSEKLKNGASKQAIESPPFRASEPLPSSNIIPNPAMERLKNGASKLAIESQPFKSAEPLSSAIPLPNPMSEKMRNGASKQAIMAQSSKINPLPPLTASISDPSFEKLKNTASKQAIESQSLMNSGPELLEPSISDPMLEKMKTDAGKQTVESLSLKSSDATIPKPSVSDLGVEKLKNDASKCAVESQSLMINDPSVSSTSFYNPNMEKLKNGAIKQAIEHQALNAAILNKTQLPYFHQSSSELPISASKRAALSQQTESASKSSSNISEMCDSHPPSNFSISASQQASKDRFSEATSSIDLDLSPGRSLSLASSKLSVKEAGARVYNRSVATPVMTPSNPFEISKSASQLASIAQVPVSEPAKTSEVNLKKSLSLASSKLSFQEAGTSLKEKTANVQHSPEVLNDRSLASLSASRHADAISSKSKQHTEIAQPAFNTTGTVLMKTKSNLSDSALSTPQHSDSVLFDITSKAARLASTCAKTDLHRKPRRKHKSFTLENYFGHNAEDESPQSDEVESQTPPSGYSENDIGGTDIYPFALQGAALAAAKDFSRREASLSDSQSAASMDMLPMKKKLSHSSASSTRSIKSLLTNANQKHIHSSINETDDIPTMAAHIVATGQKNKEKAPSFSNDQALDHLLGSAHKRIPSNKTEWSSSSLHIPSHNSFSDIHHRKIAAHAAAITAASEKLTPSIEETSYSSSKAHDASLSAATLVANKDKLIHAPTPQVLAPVLPKVSLPHRHSVSLGQIRGESEVEGDVFYDAPSDKEDLGSSNAPLDVPHGANRSSMDEVNGSKYDYSDGILDGSGQYTDSDMSDDENSLKDSQSSVLSFSAVPTKVLKFKLRDVLGSEYSPSPQLLASSSDVSGSSSAVRAAMKADKIFPAVHENPPPLKTKQSIAKPSPHTLRVPQKKHKHFYHRDDGKYKSGTNLRKSETVDLPQFFIDENRRKLYEGLWAANKGYLLSKSEYSKPNDLICNIVVRELWSRSGAPTSVLAKIYDLVDRHHTGVLGRDEFIVGMFLIDQYLKGRKLPLKVPDSVWLSSKRMGDMLWRLEKLQKKTDNKKPFFKKKKKKRKHLKKFFDFNTTAKVNEGAMTD
What is the function of this protein?
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway.  Involved in rDNA silencing (By similarity).
What are the official names of this protein?
Increased rDNA silencing protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the IRS4 family.
Protein: YRN5_CAEEL
Sequence: MELLSLAILSSFFAVANQCAATSPVTSPTTTTTEASVTTTIATSTSTTTVTTTTTVVTAACATCTTAQIGIITGNDGDMTPTSAITTDASGCSVITYTCERTPNVETDIVLITFYSDSQTPTDVGTENGVGTANVVMNCVNGEWVKDGIVINDVECQIIT
What are the official names of this protein?
Uncharacterized protein R07B1.5.
Protein: GRM2_MOUSE
Sequence: MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Signaling inhibits adenylate cyclase activity.  May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
What are the official names of this protein?
Metabotropic glutamate receptor 2, mGluR2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite.
Protein: YFBU_ECOLC
Sequence: MEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMEMYHALHVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: HEM3_SALPK
Sequence: MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEGGCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ARAB_SALPB
Sequence: MAIAIGLDFGSDSVRALAVDCATGDEIATSVEWYPRWQEGRYCDGPNNQFRHHPRDYMESMEAALKAVLAQLSAAQRANVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEADEITRLCHKPGKVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQAAVSWIELCDWVPALLSGTTRPQDIRRGRCSAGHKTLWHESWGGLPPASFFDELDPCINRHLRYPLFSETFTADLPVGTLCAEWAQRLDLPESVVISGGAFDCHMGAVGAGAQSNTLVKVIGTSTCDILIADKQSVGDRAVKGICGQVDGSVVPNFIGLEAGQSAFGDIYAWFSRVLSWPLEQLAAQHPELKTQINASQKQLLPALTDAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPALFGGLVASTAFGARAIQECFTDQGIAVNNVMALGGIARKNQVIMQVCCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPAAQQSMASAVERTLRPHPEQAQRFEQLYRRYQQWALSAEQHYLPTAAPAPTTPANQAILTH
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: HST4_YEAST
Sequence: MKQKFVLPITPPSTAEKKPQTENRCNENLKPRRLLPQLKKSVRNRKPRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVLGDCQHVTSLL
What is the function of this protein?
NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
What are the official names of this protein?
NAD-dependent histone deacetylase HST4, Homologous to SIR2 protein 4, Regulatory protein SIR2 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.