PharMolix/UniProtQA huggingface dataset:
Protein: RPOC1_SYNP2
Sequence: MKSQQEQHFDYVKIGIASPERVRQWGERTLPNGQTVGEVTKPETINYRTLKPEMDGLFCERIFGPAKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAAVTHVWYLKGIPSYLSILLDMALRDVEQIVYFNAYVVLDPGNATNLSYKQLLTEDQWLEIEEQLYSEDSQLEDVEVGIGAEAIERLLQELELEAVAEELREGIANSKGQKRAKLIKRLRVIDNFIATGARPEWMVLNSIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKIYQCGLPREMAIELFQPFVIQRLIKSTIVSNIKAAKKLIQRGDESVWDVLAEVITGHPVLLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSLEAQAEARLLMLACHNILSPATGKPIVAPSQDMVLGCYYLTAENPGAQRGAGRYFSSMDDALRAYEQGDVDLHAYVWLRYLGDVETNEADDRVLESETLEDGSILKIYRERKVRETAEGEMISQFIRTTPGRIIYNKTIQDALDLTERTLPEGLPV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: PTAK_PESFW
Sequence: MKSLFLTGLLSALTWASEFASYPDIPLDYLYTTEPVTPLPQGYPWGSKTANDSHPEEPTLTGVIRSYDFHIKAGQIAPDGYLKDVLLVNDQYPGPLIEANWGDTIQVTVHNDLEEGTALHWHAFLQKETPWQDGVPGITQCPIAPGACFTYTFVADSYGTSWYHSHYSAQYADGILGPIIVHGHPTVPYDIDLGPIMLSDLYHVPYTTVLEHLFDEDFAVVTKPANNNLINGRNSWNCTLKDLGDDTPCQSNAPLSEFRLTPGKKHRLRILNVGGSAIQKFSLDGHKLQVIAHDFVPVLPYEVEFLTLGVGQRADVIVEALANGTGTYTMRATIPPAPCANSVDHDATALVHYGNTTSTFSNSSSEAWPSFIEALGVCDGLPTEEITPWYAIPAPEAPATTQIINVTLAQNETGQYLFYMDNSSFRVNYNHPVLLLSNLGNNSYPDDPEWNVYNFGSNNSIRIVMYNNAIRTHPIHLHGHNFFVEAVGLGEWDGHVDHPENPVRRDTAMLPQGGYMVISFNADNPGAWPLHCHVAWHVSSGFYVTVLERPDEIAEYKIPSVVGQTCRDWWGYTNHTIVNQIDSGL
What is the function of this protein?
Oxydoreductase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702).  As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702).  The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702).  Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702).  Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702).  An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702).  PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702).  PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702).  Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702).  Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702).  PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulochrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
What are the official names of this protein?
Oxydoreductase ptaK, Pestheic acid biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
Protein: VM2AE_CROAT
Sequence: MIQVLLVTICLAAFPYQGSSIILESGNVNDYEVIYPRKVTALPKGAVQPKYEDTMQYELKVNGEPVVLHLEKNKGLFSKDYSETHYSFDGRKITTNPSVEDHCYYHGRIENDADSTASISACNGLKGHFKLQGEMYLIEPLKLSDSEAHAVFKLKNVEKEDEAPKMCGVTQNWESYEPIKKASDLNLNPEHQRYVELFIVVDHGMYTKYNGDSDKIRQRVHQMVNIMKESYTYMYIDILLAGIEIWSNGDLINVQPASPNTLNSFGEWRETDLLKRKSHDNAQLLTSIAFDEQIIGRAYIGGICDPKRSTGVVQDHSEINLRVAVTMTHELGHNLGIHHDTDSCSCGGYSCIMSPVISDEPSKYFSDCSYIQCWEFIMNQKPQCILKKPLRTDTVSTPVSGNELLEAGIECDCGSLENPCCYATTCKMRPGSQCAEGLCCDQCRFMKKGTVCRVSMVDRNDDTCTGQSADCPRNGLYG
What is the function of this protein?
Potent inhibitor of both collagen- (IC(50)=4 nM) and ADP-induced (IC(50)=8 nM) platelet aggregation.  May act by binding to the platelet receptor GPIIb/GPIIIa (ITGA2B/ITGB3).
What are the official names of this protein?
Zinc metalloproteinase/disintegrin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RB11A_DICDI
Sequence: MTSKGSQEEYDYLYKIVLIGDSGVGKSNLLSRFTRNEFSLETKSTIGVEFATRTIQTEGKTIKAQVWDTAGQERYRAITSAYYRGAVGALLVYDIAKQATYKSVERWILELRENADRNIEIMLVGNKSDLRHLREVSTDEAKEFSEKHKLTFIETSALDSSNVELAFQNILTQIYHIMSRPSHSTGPQTTIDSNTETIILPTTSEPPAAKSGCC
What is the function of this protein?
Required for normal contractile vacuole structure and function.  Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders.  These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles.
What are the official names of this protein?
Ras-related protein Rab-11A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Contractile vacuole membrane; Lipid-anchor; Cytoplasmic side.
Protein: TMC7_CHICK
Sequence: MSEFGAGAELPGWVTESRSRGEFFSPEESHAAAPAGFLQELPSYRSVLWRRAAAGDVQERWGNLRGIASAERREPQPDGGERGAIPLWELPFSIAEKRDSQQGDIKYSSGWNHWKRTSSKSWKKALKDIKELSSYMQLWRHDIHSIEGKFGTGIQSYFSFLRFLVLLNFLMFILMFSFVTLPAVISNYGIFNSSSTKISPNNTEPYCTVYTPSGNKGLVYFYTYLKDLLTGTGFLEVTVLFYGYYTIDAAWFSVLRYNLPLAYLLTTFAYLALSFVWIIKRSVERFRQHLVDDEDQFQSYCNKVFAGWDFCITDLNAARLKHRSLLYELQTNLEEERLKQKIAERTMKEKLQIYSLRIFINIIVIAVLSGCFYSIYRATVFSQENSSVSIRRNVMIANLLVQYLPSIVITSANFIAPQIFSFLIRFEDYSAAFEIRLTLIRCVFVRLANVGVLLFSLWSQIHCDNDQCKACGYDYELYPCWESAVGQEMYKLLIFDFMIIIAMTLFVDFPRKLLVTYCSWKLVQWWGLQEFGISDNVLEIIYGQTICWIGTFFSPLLPAIATIKYFIIFYIKKISLIHTRKPASRPIRASSSNFFFLAVLLIGLILAFVPLGVSIALISSSKACGPFRNFNTSWAIVPYTILEFPIGLQKFLYGIASEAFAVPFFVIACLFMFYFIALAGAHKRVVEQLREQLVTESRDKLFLLEKLSEAQKNSGKPQKARKLTSSWLLEPLDKG
What is the function of this protein?
Probable ion channel.
What are the official names of this protein?
Transmembrane channel-like protein 7.
What is the protein family that this protein belongs to?
Belongs to the TMC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NADE_PYRHO
Sequence: MRILDYDKVIERILEFIREKGNNGVVIGISGGVDSATVAYLATKALGKEKVLGLIMPYFENKDVEDAKLVAEKLGIGYKVINIKPIVDSFVENLELNLDRKGLGNIMSRTRMIMLYAHANSLGRIVLGTSNRSEFLTGYFTKWGDGASDYAPIINLYKTEVWEIAKRIGVPERIVKKKPSAGLWEGQTDEDELGISYNLLDEILWRMIDLKIGKEEIAKDLGIPLSLVERVEELIKKSEHKRRLPIGPSFEDLIVGP
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: B_BPCHP
Sequence: MKFRTIYDEERPAPVLECKDESLCLAYQCTETSIEKLVKLANQNPSYLHAFAGDPTRQPEYGECPSPLDYQDALEIVARGEEAFYSLPANIRVNFSNPMEFLSWLEDPANYDEVEKLGLLDPEKVQIRKSKLQKDQKEEVSSEEK
What is the function of this protein?
Participates in the assembly of the viral procapsid in the cytoplasm.  Released from the procapsid upon genome packaging, possibly through affinity displacement by the protein ORF8, or by proteolysis (By similarity).
What are the official names of this protein?
Internal scaffolding protein VP3, Protein VP3, VP3.
What is the protein family that this protein belongs to?
Belongs to the microviridae B protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: EDA40_ARATH
Sequence: MMNGLRRTFWSSIHKKKDNNRVDDSLDRQKPTTTSRFGFFSNPSTPRSETRPDSVTCSPTIPCQSWSATAISTPSPSLPASPKLQCDTSGDVTPTRNRSPLSFLSVSSSSSTPSSPKSPASFSLLKSKLCFTKVRILNRNNQVNIFKNNSKLTFLRLCYEQSSISSSKCGICLQSAKAGRGTAIFTAECSHTFHFPCVASRAGDRNLLSDCPVCGASWRETSLLPLSLSSSLHESGSESDSKIRESKNNNKSLRVYNDDEPLISSPISRTGFNTIPESNEDEEEEDNDDGEFKGFYVNTPSPLTTKKMLTDSVTGHVDVKLSSEAAIVAVGRGNETYSVLMKIKSPSLPTARRSPVDLVTVIDVSGGNIEMVKRAMRQVISSLRETDRLSMVSFSSSSKRLTPLRRMTANGRRLARRIVDDISGDGDGMSVNDAVKKAAKVIEDRRQKNLFTTIFVLTDRNRNSAHQAQLAQPDFVTSTRFSHLEIPTHTIWLGACNHALPEDVFAKRIKSLLSLSVQDLTLNLGLVSGSGQGKVTSVYSLSGRPVWLGSGLIRLGDMYGDEEREVLVELKSPSSSRSQRIMTVRSRHVDPTTQEIKNYEDRALMIPRPTTVRSSDPSIARLRNLHVSTRAVAESRRLVEVNDYSGAERMLTSARALLVQYGLSSSDSCLRGLEAELADLNRLRGRHVAVKSPEPVVQKSEPLTPTSAWRAAERLAKVAIMRKHMNRVSDLHGFENARF
What is the function of this protein?
Probable E3 ubiquitin-protein ligase involved in female gametophyte development.  Required for fusion of polar nuclei in the embryo sac.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase EDA40, Protein EMBRYO SAC DEVELOPMENT ARREST 40, RING-type E3 ubiquitin transferase EDA40.
Protein: ASNA_ECO81
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_RICM5
Sequence: MLNINFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIKVIPSVIKSGEVRYLIIAGLGNEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNSTETAKLFEIKKLIAEAVFFTRDISNEPSNIKTPQVYAERIVDILEPLGVDVDVIGEREMKNLGMGALLGVGQGSQNESKLVVMEYKGGSKDASTIALVGKGVIFDTGGISLKPSSNMHLMRYDMGGSAAVVGTIIAVAGQKLPINIVGVVGLVENMPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKCVIDVATLTGAITVALGNTYAGCFSNNDELADKLIKVGEEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPGAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALGPKGAVGYGVRLLEKFIKEYT
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_NATPD
Sequence: MGLYQLLKPALFQLDAETAHGLGHRVLDGIQGTPLERIVADYCTVVDPRLRVDAFGQTFPNPVGVAAGFDKNAEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMFRLAEDRALINRMGFNNDGADIVGERLAATDCRVPVGVNIGKSKSAANDDAEADYQYTYERVADGGDYFVVNVSSPNTPGLRELQSRDRLESILGTLQDDGASPLLVKLSPDLTDAAIEDAIEVVEDLGLDGIIATNTTTKRPASLHSDAADEEGGLSGAPITDESTDIVRFIAKRTDKPIVGVGGIDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDINRGLLKLLERDGFASVEDAVGVDI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: WNT2_OTOGA
Sequence: MNAPLCGIWLWLPLLLTWLTPEVSSSWWYMRATSGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGTAKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGSYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSRVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTPT
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).  Functions as upstream regulator of FGF10 expression.  Plays an important role in embryonic lung development.  May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: HEYL_HUMAN
Sequence: MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF
What is the function of this protein?
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).  Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).  Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif-like protein, hHeyL, Class B basic helix-loop-helix protein 33, bHLHb33, Hairy-related transcription factor 3, HRT-3, hHRT3.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UBIE_NEIMB
Sequence: MGGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKKGDKVLDIAGGTGDLSRGWAKRVGKEGEVWLTDINSSMLTVGRDRLLNEGMILPVSLADAEKLPFPDNYFNLVSVAFGLRNMTHKDAALKEMYRVLKPGGTLLVLEFSKIYKPLEGAYDFYSFKLLPVMGRLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALHKGVKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: TUSE_BUCBP
Sequence: MNYIPDWNEELAKKIAKSEFINMTPDHWEIIYIIRNFYLNFNLAPSIRILIKTLEKMKYNKKKCSSRYLLKLFPKNPIKQASKIAGVPKTNDCI
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Could accept sulfur from TusD (By similarity).
What are the official names of this protein?
Sulfurtransferase TusE, tRNA 2-thiouridine synthesizing protein E.
What is the protein family that this protein belongs to?
Belongs to the DsrC/TusE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PANLE
Sequence: MTNIRKSHPLVKIINHSFIDLPTPPNISAWWNFGSLLGVCLILQILTGLFLAMHYTPDTMTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLYMHVGRGMYYGSYTFSETWNIGIVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGADLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGMVSDSDKIPFHPYYTIKDILGLLVLILTLMLLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPALHTSKQRGLMFRPLSQCLFWFLVADLLTLTWIGGQPVEHPFITIGQLASILYFSILLILMPISGIIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PUR4_YERPS
Sequence: MEILRGSPALSAFRITKLLSRCQDAHLPVSDIYAEYVHFADVSAPLSADEHARLQRLLQYGPSLPEHPPAGRLLLVTPRPGTISPWSSKATDIAHNCGLSQILRLERGLAFSIQGPNLNEGQWKQLAALLHDRMMETVFTDLQQAEQLFSHHQPAPVQRVDILGQGRSALEQANIKLGLALAQDEIDYLLTAFTGLGRNPTDIELYMFAQANSEHCRHKIFNADWVIDGVAQPKTLFKMIKNTFEHTPDYVLSAYKDNAAVMEGSQVGRFYATAEKGIYDYHQEEAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEENFGKPDRIVTALDIMTEGPLGGAAFNNEFGRPALLGYFRTYEERVNSHNGIELRGYHKPIMLAGGLGNIRADHVQKGEITVGAKLVVLGGPSMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGEYNPILFIHDVGAGGLSNAMPELVNDGGRGGRFELRDILNDEPGMSPLEVWCNESQERYVLAVAPAQMALFDEICRRERAPYAVIGEATEEKHLLLNDRHFGNQPIDMPLDVLLGKTPKMLRDVTRLQAKGDALQRADISLAEAVKRIMHLPAVAEKTFLITIGDRTVTGMVTRDQMVGPWQIPVADCAVTSASLDSYYGEAMSLGERAPVALLDFAASARLAVGEALTNIAATQIGELKRIKLSANWMSAAGHPGEDAGLYDAVRAVGEELCPALEITIPVGKDSMSMKTRWQEGHEQREMTSPLSLVITAFARIEDVRRTVTPQLRTDKGDNALLLIDLGAGHNALGATALTQVYRQLGDKPADVRNVQQLAGFFNAMQRLVADQHLLAYHDRSDGGLLVTLAEMAFAGHCGVTVDIQSLGNDALAALFNEELGAVIQVRAEQRADVEKLLADHGLANCVHYLGRAVAGDTFDIRSGTDVVYSEKRSTLRLWWAETSWQMQRLRDNPDCADQEHQAKQDESDPGLNVKLTFDPAEDIAAPFILKQARPKVAVLREQGVNSHVEMAAAFHRAGFDAVDVHMSDLLAGRTDLQSFQTLVACGGFSYGDVLGAGEGWAKSILFNDRVRDEFEAFFHRPTTLALGVCNGCQMMSNLRELIPGAEHWPRFVRNLSDSFEARFSLVEVASSPSLFMQDMVGSRMPIAVSHGEGQVEVRDAAHLAALEQSHLVALRFVNNHGVVTEQYPANPNGSANGITAVTSVSGRATVMMPHPERVFRTVSNSWHPEEWGEDSPWMRMFRNARKQLG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YI21A_YEAST
Sequence: MFELIPRIILELYGCCWTPLGVLFGYTLFRNACQFQFLTFSQFTNKNTVTFFILYNRMPNITAHEIRHNYQVLAVDVCSTFAFAERLQC
What are the official names of this protein?
Putative uncharacterized protein YIL021C-A.
Protein: CTU1_DROPS
Sequence: MPINCKAKCGKAAALKRPKTGDALCKECFFAAFEAEIHHTITSSKLFRRGEKVAVAASGGKDSTVLAHVMKLLNERHDYGLELVLLSIDEGITGYRDDSLETVKQNRDDYKMPLKILSYEELYGWTMDRIVSQIGRSNNCTFCGVFRRQALDRGAKLLCVDSIATGHNADDIAETVLMNVLRGDTARLRRCTDIRTGGGEDSIPRVKPLKYSYEKEIVMYAHYKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSVIMDIIYSGEQLRFKDTAKNPVRGTCNRCGFISSQQPCKACVLLEGLNRGLPKLGIGKKSKGDRMIAKQDQELALRERANLVKNDF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4A_TRYCC
Sequence: MAQQGKVEPQDQDSFLDDQPGIRPIPSFDDMPLHQNLLRGIYSHGFEKPSSIQQRAIVPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNVLQGLVLSPTRELALQTAEVITRIGEFLAEGNSSFCATFVGGTRVQDDYRKLQAGSIVAVGTPGRVVDVTKRGAMRTEHLRVLVLDEADEMLSQGFAEQIYEIFRYLPKEIQVALFSATMPDDVLELTKKFMRDPTRILVKRESLTLEGIKQYFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWLAQQLNQSNHTVSCMHSEMPKQDREKVMSTFRNGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKESYLHRIGRGGRYGRKGVAINFVTQKDVEVLREIESHYHTQIDELPVDFAAYLGE
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Probable eukaryotic initiation factor 4A, eIF-4A, ATP-dependent RNA helicase eIF4A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: YBEY_LIMF3
Sequence: MELQLRDHTEGKLQPSQERLAEKALAQAAERLDVPEQAEMSLTFVLNPEIRELNRDYRGIDRATDVISFAIEDDDDLANLPAEIRAELPVELGDLVISIDKVTEQALFLNHSADRELGYLLVHGFLHLNGYDHEEPADEEKMFTLQEEILDGLGLSR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD3_MOUSE
Sequence: MKQEGSARRRGADKAKPPPGGEQEPPPPAPQDVEMKEEAAAGSGSTGEGDGKAAATEHSQRELDTVTLEDIKEHVRQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVHGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASAPLLPEVEAYLQLLMVIFLMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQTDGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit RPN3, 26S proteasome regulatory subunit S3, Proteasome subunit p58, Transplantation antigen P91A, Tum-P91A antigen.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S3 family.
Protein: PYRC_HELPJ
Sequence: MEITLFDPIDAHLHVRENALLKAVLEYSSEPFSAAVIMPNLSKPLIDTPITLEYEEEILKNSSNFKPLMSLYFNDGLTLEELQRAKNKGIKFLKLYPKGMTTNAQNGTSDLLGEKTLEVLENAQKLGFILCVHAEQAGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLDPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDSAPHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPSKKAHLSKKPFIVPTHTLCLNEKIAILRGGETLSWNLQEIA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.