PharMolix/UniProtQA huggingface dataset:
Protein: CDC27_BOVIN
Sequence: MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNSCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTSSVIDVPPTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Cell division cycle protein 27 homolog.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: TREZ_MYCTO
Sequence: MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADARYGYLLDDDPTVLPDPRSARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYELHIGTFTTAGTFDAAIEKLDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPYGGPDGLVRFIDACHARRLGVLIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAGADSDEVRHYIIDCALRWMRDFHADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLGRPLSLIAETDRNDPRLITRPSHGGYGITAQWNDDIHHAIHTAVSGERQGYYADFGSLATLAYTLRNGYFHAGTYSSFRRRRHGRALDTSAIPATRLLAYTCTHDQVGNRALGDRPSQYLTGGQLAIKAALTLGSPYTAMLFMGEEWGASSPFQFFCSHPEPELAHSTVAGRKEEFAEHGWAADDIPDPQDPQTFQRCKLNWAEAGSGEHARLHRFYRDLIALRHNEADLADPWLDHLMVDYDEQQRWVVMRRGQLMIACNLGAEPTCVPVSGELVLAWESPIIGDNSTELAAYSLAILRAAEPA
What is the function of this protein?
Is involved in the biosynthesis of trehalose but not in that of capsular glucan and glycogen.
What are the official names of this protein?
Malto-oligosyltrehalose trehalohydrolase, MTHase, 4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase, Maltooligosyl trehalose trehalohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_CHLCV
Sequence: MSKETFQRNKPHINIGTIGHVDHGKTTLTAAITRALSAEGLANFCDYSSIDNTPEEKARGITINASHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSATDGAMPQTKEHILLARQVGVPYIVVFLNKIDMISQEDAELVDLVEMELSELLEEKGYKGCPIIRGSALKALEGDASYVEKIRELMQAVDDNIPTPEREVDKPFLMPIEDVFSISGRGTVVTGRIERGIVKVGDKVQIVGLRDTRETIVTGVEMFRKELPEGQAGENVGLLLRGIGKNDVERGMVICQPNSVKSHTQFKGAVYILQKEEGGRHKPFFTGYRPQFFFRTTDVTGVVTLPEGTEMVMPGDNVEFEVQLISPVALEEGMRFAIREGGRTIGAGTISKIIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGFZ_YERE8
Sequence: MANNTPFAAQPLLTSSELPLTLISLDDWALVTLTGADRVKYLQGQVTADIDALPTDQHVLCAHCDAKGKMWSNLRLFYRGEGLAFIERRSVLDNQLSELKKYAVFSKVVIAAQPDAVLLGVAGTQAKAVLAEVFAELPNADHPVVQQGDSTLLYFSLPAERFLLVTDTEQAQQLVEKLADRAQFNNSKQWLALDIEAGFPIIDTDSSAQFIPQATNIQALNGISFSKGCYTGQEMVARAKYRGANKRALYWLAGSANRAPAVGEDLEWQLGENWRRTGSVLAAITLSDGTVWVQAVLNNDLAADSVLRVRDDAESVLTIQPLPYSLTEDK
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIO_ERYPA
Sequence: MLVVFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWHKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: CAPSP_ADECC
Sequence: MEFPSSPPPSYETVMAQVPSILAPLVPPRYKGATEGRNSIRYSQLPPLFDTTKLYLIDNKSSDIQALNYQNDHSNFLTTVVQNANYTPMEASTQSIQLDERSRWGGDFRSILHMNMPNVTEYMFSNSFKAYLPATADASGKVLTYEWYTLTIPEGNYSEVMLLDLLNNAVVENYLAHGRQHNVKEEDIGLKFDTRNFYLGFDPETELVMPGFYTNEAFHPDIILSPGCAVDFTHSRLNNFLGIRKRLPYQEGFIIKWEDLQGGNIPALLDLEIYNPDTPGDNITPLLQDSKARSYHVGEDPSAGSTFTSYRSWFLAYNYGPVDGIKSKTVLVAPDITCGVEQIYWSLPDMAVDPVTFTSSHNPSSYPVVGTELLPLLPRSFYNGSSVYSQLLQESTAQTHVFNRFPENAILKRPPAPTIISISENVPALSNHGTLPLKNNIPGVQRVTITDARRRVCPYVYKSLGVVVPRVLSSKTF
What is the function of this protein?
Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid.  Involved in virus secondary attachment to host cell after initial attachment by the fiber protein, and in endocytosis of virions.  As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
What are the official names of this protein?
Penton protein, CP-P, Penton base protein, Protein III.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae penton family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Located at each vertex of the virion.
Protein: BACD1_BOVIN
Sequence: MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission.  The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission.
What are the official names of this protein?
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1, BTB/POZ domain-containing protein KCTD13.
What is the protein family that this protein belongs to?
Belongs to the BACURD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FTSB_HAEIG
Sequence: MRLLILILLSVLVLFQYNFWFGSNGFLDYRQNAEKIKENQAENEKLSQRNQRINAEIQGLTKGFEAIEERARMQHGLVKENEVFYHIVKESK
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: GLMU_SALPB
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADLKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLHCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_FRATH
Sequence: MNISNIKIMLLGSGELGKEFIIAAQRLGIHTIAVDRYKNAPAMQVAHESYVIDMLNSDALEQLILAKNPTYIVPEIEAINTDSLVKLEAHNFNIIPCAKATKLTMDRQGIRALAVQQLNLQTSKFAFANSEQEYLDVIQSIGLPFVIKPVMSSSGKGQSIVKEHNEIKKAWDYAQNGSRGHAKGVIVEQFIDFDYEITLLTVRHKDGTSFCDPIGHIQKDGDYRFSWQPHTMPDTALAKSQEIAKEITDALGGYGVFGVELFIKGDEVFFNEVSPRPHDTGMVTLISQNINEFELHLRAIVGLPIPDIQTLQPSASAAILLEGDTANASICGIDKALADANVDIRIFSKKEIHGKRRMGVVLAKAQNTHIALETSKQALAHIHLTK
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: CLPP1_BACCZ
Sequence: MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1618_CLOPE
Sequence: MEEKQIMAFRDEEGNKVEFEVVAKIYLGEKNKKEYIVLSPVEGNGDEADDFVFRVDKVNDSVEYNLVEDDEEFRLVKKEYKKLLY
What are the official names of this protein?
UPF0473 protein CPE1618.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: RLME_ZYMMO
Sequence: MKTPGHQRVKTARRRTAASTRWLERQLNDPYVQKAQAEGYRSRAAFKLIELDERFSLLKNARRIIDLGIAPGGWSQVARKKAPQAKIVGIDLLEAAPIEGVTIFQNDFTDPEAQKKLIEALGGAADLVLSDMAANTIGHAQTDHLRTMALVEEAAVFASETLREGGSFVAKVLAGGADKDLVALLKRLFGQVKHAKPPASRRESSEWYVIAQNFRGEAYQG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSIB_SHIFL
Sequence: MARAVHRSGLVALGIATALMASCAFAAKDVVVAVGSNFTTLDPYDANDTLSQAVAKSFYQGLFGLDKEMKLKNVLAESYTVSDDGITYTVKLREGIKFQDGTDFNAVAVKANLDRASDPANHLKRYNLYKNIAKTEAIDPTTVKITLKQPFSAFINILAHPATAMISPTALEKYGKEIGFHPVGTGPYELDTWNQTDFVKVKKFAGYWQPGLPKLDSITWRPVADNNTRAAMLQTGEAQFAFPIPYEQATLLEKNKNIELMASPSIMQRYISMNVTQKPFDNPKVREALNYAINRPALVKVAFAGYATPATGVVPPSIAYAQSYKPWPYDPVKARELLKEAGYPNGFSTTLWSSHNHSTAQKVLQFTQQQLAQVGIKAQVTAMDAGQRAAEVEGKGQKESGVRMFYTGWSASTGEADWALSPLFASQNWPPTLFNTAFYSNKQVDDFLAQALKTNDPAEKTRLYKAAQDIIWQESPWIPLVVEKLVSAHSKNLTGFWIMPDTGFSFEDADLQ
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Binds glutathione.
What are the official names of this protein?
Glutathione-binding protein GsiB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PLK2_RAT
Sequence: MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQSQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPPTTFAKSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQNEEYLLTYINEDRISTTFRLTTLLMSGCSLELKHRMEYALNMLLQRCN
What is the function of this protein?
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition.  Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains.  Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1.  Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome.  Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity.  Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression.  Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively.  Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
What are the official names of this protein?
Serine/threonine-protein kinase PLK2, Polo-like kinase 2, PLK-2, Serine/threonine-protein kinase SNK, Serum-inducible kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Protein: RL18A_SULIK
Sequence: MSEIKFYLVKGSALFGESHYPEKRKFVKIVRALNEKQAIEYIYSYFGSKNKIKRYNIKIEQISEIKEEEIPDRRIRELAKIDKIIM
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: COXX_STAES
Sequence: MNKDQTLSHTTGRVSFKELQQIIKMGLVQGNLIPAFAGAWLAIVMTNHSFLSSIPQILLMLVGSTLIMGGACALNNYYDQDIDRIMPSKQGRPTVNDRISDRNLLMLSFGMMLIGEACLFLLNIPSGVLGLIGIVGYVSYYSIWSKRHTTWNTVVGSFPGAVPPLIGWVAIDGSLSLAAVALFLVVFCWQPIHFYALAIKRSDEYALANIPMLPSVKGFKRTRVSMFIWLVLLLPLPFLLSNLGVTFVVIATLLNLGWLALGFTTFRKESNQTKWATQMFVYSLNYLVVFFALVVVVSLIKMI
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACCA_STAA8
Sequence: MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYIE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2B2_BOTJR
Sequence: MRTLWIMAVLLVGVEGDLWQFGQMILKETGKLPFPYYTTYGCYCGWGGQGQPKDATDRCCFVHDCCYGKLTNCKPKTDRYSYSRENGVIICGEGTPCEKQICECDKAAAVCFRENLRTYKKRYMAYPDVLCKKPAEKC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows low enzymatic activity even tough it conserves the catalytic residues (PubMed:9619591).  Shows a strong myotoxic activity and induces indirect hemolysis, anticoagulant properties, and cytotoxic activities (PubMed:11018293).  In vivo, it induces muscle necrosis, accompanied by polymorphonuclear cell infiltration, and edema in the mouse paw (PubMed:1660822, PubMed:11018293).  It exerts its function even in the absence of extracellular calcium, indicating it is not a calcium-dependent enzyme (PubMed:20878713).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog bothropstoxin-II, Bothropstoxin II, BthTX-II, BtxtxII, svPLA2 homolog, BJU-PLA2, BJUPLA2, BOJU-II, Myotoxic phospholipase A2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCA_CELJU
Sequence: MNLNYLDFEQPIAELEGKIEELQLVGNSSDVNLADEVAKLREKSTKLTETIYSKLTAWDIVKVARHPQRPYASDYISRVFTEFDELHGDRHFGDDKAIIGGVGRLDGKPVMVIGEEKGRSVHEKVMRNFGMPRPEGYRKALRLMEMAERFKLPVLTLIDTPGAYPGIDSEERGISESIAQNLAVMSRLRTPIVCTVIGEGSSGGALAIGVGDHLNMLQYSTYFVISPEGCANIIWKTVAKAPEAAQAMGVTSKVLQDLGIVDETIPEPLGGAHRNVDEMARKLQERLVEQVEQLSREPIDALLERRYQRLMSYGN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLUE_ECO57
Sequence: MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREATE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase E, rRNA pseudouridylate synthase E, rRNA-uridine isomerase E.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: IRAD_ECO57
Sequence: MMRQSLQAVLPEISGNKTSLLRKSVCSDLLTLFNSPHSTLPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.