PharMolix/UniProtQA huggingface dataset:
Protein: FOLD_BURCJ
Sequence: MTALLIDGNALSKTLRGQAAERAAALTARGHQPGLAVILVGENPASEVYVRNKIKACEDNGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLLDAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIESAERAAAAAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: NSUN4_MOUSE
Sequence: MAAPVLRCVRKLLKLVDFTPVPRRYRYKKKWATTEPQFTASRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDSVSAKLEQLSAKDFVSEAISHQKLEPESGLSPTPSLDCSPNLRCFTFSRGDVSRFPPARLGSLGLMDYYLMDAASLLPVLALGLQHGDTVLDLCAAPGGKTLALLQTGCCRNLAANDLSTSRTGRLQKVLHSYVPQDIREGNQVRVTSWDGRKWGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFQRSRKKERQMLPMLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYNIKVQVEDLSHFRKLFMDTFCFFPSCQVGELVIPNLMVNFGPMYFCKLHRLP
What is the function of this protein?
Involved in mitochondrial ribosome assembly.  5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA at position 911; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU).  Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled.  In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
What are the official names of this protein?
5-methylcytosine rRNA methyltransferase NSUN4, 5-methylcytosine tRNA methyltransferase NSUN4, NOL1/NOP2/Sun domain family member 4, Sperm head and tail associated protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NU2M_CHEPA
Sequence: MNPLIMSIIMSTIILGTLIVMTSSHWLMIWIGFEMNMLAIIPMLMKHHNPRSTEAATKYFFTQATASMLLMLAVIINLMYSGQWTGMKLFNPTASIIMTLALTMKLGLAPFHFWVPEVAQGIPLSSGLILLTWQKLAPLTVLYMISPAINLYLLLTMSMASIAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAILIYNPTMTLLNLVIYILMTTTMFMLLMINSSTTTLSLSHMWNKMPLITTITLVTLLSLGGLPPLTGFLPKWMIIQELTKNDSIILPTLMAITALLNLFFYMRITYATSLTMFPTTNNMKIKWQFENTKHLNLLTPMIVLSTLTLPLAPMMTILN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MNMG_SALEP
Sequence: MFYQDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVSRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRNNLDRSPMYAGVIEGIGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIHGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEMGRELGLVDDERWARFNEKLESIERERQRLKSTWVTPSAESADEVNAHLTTPLSREASGEDLLRRPEMTYAQLTSLAAFAPALEDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_STRA3
Sequence: MRIFEKAPAKLNLGLDIKGRCDDGYHELAMIMVSIDLNDYVTISELKEDCIVIDSDSSKMPLNNDNDVFKAADIIKNQYGINKGVHIRLEKSIPVCAGLGGGSTDAAATIRALNRLWNLQMDYDEMVAIGFKIGSDVPYCLGGGCSLVLGKGEIVKPLPTLRPCWIVLVKPDFGISTKSIFRDIDCKSISRVDIDLLKSAILSSDYQLMVKSMGNSLEDITITKNPVISTIKERMLNSGADVALMTGSGPTVFSMCSTEKKADRVFNSMKGFCKEVYKVRLLR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: TNR5_MOUSE
Sequence: MVSLPRLCALWGCLLTAVHLGQCVTCSDKQYLHDGQCCDLCQPGSRLTSHCTALEKTQCHPCDSGEFSAQWNREIRCHQHRHCEPNQGLRVKKEGTAESDTVCTCKEGQHCTSKDCEACAQHTPCIPGFGVMEMATETTDTVCHPCPVGFFSNQSSLFEKCYPWTSCEDKNLEVLQKGTSQTNVICGLKSRMRALLVIPVVMGILITIFGVFLYIKKVVKKPKDNEILPPAARRQDPQEMEDYPGHNTAAPVQETLHGCQPVTQEDGKESRISVQERQVTDSIALRPLV
What is the function of this protein?
Receptor for TNFSF5/CD40LG (By similarity).  Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor.
What are the subcellular locations of this protein?
[Isoform I]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform III]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform IV]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform V]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform II]: Secreted.
Protein: UREF_METFK
Sequence: MSKSRSLVRLLQLASPMLPVGAYSYSQGLEWGIESGEVHDLESAQAWIGDVLQVYQGGFELPVLSRCYRAWQRGDVEALNEWNAFYLAGRDNAEALAESRQMGYSLKRLLLEFEELSGAWATMLEALPNASFPALYAGISQAWEIEEQDALQAYAWSWLENQASAAMKAVPLGQVAGQKILLGVAGKIPVLVEAAIQMQDHEISNFCPALTIAGCRHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPYM_PONAB
Sequence: MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLLTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSGVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
What is the function of this protein?
Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.  The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production.  The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
What are the official names of this protein?
Pyruvate kinase PKM, Pyruvate kinase muscle isozyme.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLN11_HUMAN
Sequence: MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNSGGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKRKPKILEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVHFCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVEDKYVCSLTTEKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH
What is the function of this protein?
Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061).  Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061).  Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061).  Acts independently of ATR (PubMed:29395061).  Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900).  Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900).  Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900).  The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900).  Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).
What are the official names of this protein?
Schlafen family member 11.
What is the protein family that this protein belongs to?
Belongs to the Schlafen family. Subgroup III subfamily.
Protein: YBEY_LACDB
Sequence: MQGIDVSYSDEVGFLTKGDRDWEDWIMQLLLMAKKEIGKDNAQEMSINFVDEDRSQAINRDYRDKDRPTDVISFAIEDGDDGLDLAMFTQDPDFTEDIGDLFMCPSVIERHSKEYGTGFDREFGYTIVHGYLHLNCYDHIEPDEAKEMFGIQGKVLEEYGLPLYPDQLDEGRGK
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYFIP_DROPS
Sequence: MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATTHANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQRKAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEKHMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHFDSSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTTVKENPSDAENRITADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVIAMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSADWQKGYEPTDDPVSKGKKDPDGGFRIHVPRLNVGPSSTQLYMVRTMLESLTADKSGGKRTLRKDIDGNCLMQIETFHNTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCMVRHQHNEECKDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAHYALTVFRKQFLYDEVEAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHVQLLGRSIDLNKLVTQRINANMHKSIELAISRFEANDITGIVELEGLLEANRICHKLLSKYLALDNFDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSTQAIQREKPPQMSHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQFTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDTKTELFQSFREFGNCIIFCLLIEQALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIAREGDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPVRGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDRIRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISSSSHYQDPQKLRQSMNN
What is the function of this protein?
Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology.  Also required for formation of cell membrane protrusions and for bristle development (By similarity).
What are the official names of this protein?
Cytoplasmic FMR1-interacting protein, Specifically Rac1-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the CYFIP family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Accumulates in central axons and motor neuron terminals.
Protein: KLRA6_MOUSE
Sequence: MSEPEVTYSTVRLHKSSRLQKLVRHEETQGPREAGYRKCSVCWQLIVKALGILCFLLLITVAVLAVKIFQYGQHNQEIHETLNYHHNCSNMQSDFNLKEEMLTNRSIDSRPGNELLESLNREQNRGYSETKTDLDSSQDTGTGVKYWFCYRTKCYYFIMNKNTWSGCKQNCQHYSLPLVKIDDENELKFLQFQVIPDSYWIGLSYDKEKKEWAWIDNGQSKLDMKIRKMNFKPGGCVFLSKRRLEDTNCKNSHYCICGKKLDKFPH
What is the function of this protein?
Receptor on natural killer (NK) cells for class I MHC.
What are the official names of this protein?
Killer cell lectin-like receptor 6, Lymphocyte antigen 49f, Ly-49f, T-cell surface glycoprotein Ly-49F.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NP1L5_HUMAN
Sequence: MADSENQGPAEPSQAAAAAEAAAEEVMAEGGAQGGDCDSAAGDPDSAAGQMAEEPQTPAENAPKPKNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGEEEEEEEYEDDEEEGEDEEEEEAAAEAAAGAKHDDAHAEMPDDAKK
What are the official names of this protein?
Nucleosome assembly protein 1-like 5, Down-regulated in liver malignancy.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OSW1_YEAST
Sequence: MRAPPSPRKSKSGHFFYLYFRLCQLFSGRKLKRRWHVHKLHIHQYNTRWNLSPLSEIHIEDMINEPSGLCPGSSKKKPLLIARFPKGCQESPRVYVLQRNNLSRLKLSKRKYALRFYHNEIFGNNLKRKDGSIHKVEHQQCAETVRKIKKVTANHADVKIIFHDKNTIRSDKLGGRSNKMQTRPSVLEEDVEEEVSSVYIRFCDDHSLRVKDYHSLHRHSKKSSKEKRNNQEIGKSKLLGKLFEEETSRQNKGVEKKLDTIVIQKFQNYPIVSFSRVI
What is the function of this protein?
May be involved in a late step of spore wall assembly.
What are the official names of this protein?
Outer spore wall protein 1.
What are the subcellular locations of this protein?
Spore wall. Note=Predominantly at sites of spore-spore contact.
Protein: XYLT_CAEBR
Sequence: MVVVGGVNTNYRHYALVIVLFFFLNVYLLYSAQNSVQIRKDEGETREKFQTPKVPLVDPISTCEIVDELAKSAISRATSPGCKSKLQLEACQLKNGTFSESFPQSTCSNHQDALIDQRIGCFLDKKDARVLKEFEYKFPQSNSKSTCRKNCYKAGFLYYGLEFGLECFCGNDVANATEIDSGECRNYKCPGAEDEFCGGFNAVEIFRTDKLVMLKPKYLPPAENVSKPPIKILFLLQLNGRNERQVKRFLKSIYLPNHYYYIHVDKRQNYMYSEMAKIAEKVPNIHITSTRYSTIWGGASLLQMFQQVIRDSMEIEMFKDWDYIFNFSESDFPILPIQDFERLITEHQGKSFLASHGYNTGKFIQKQGFEFVFSECDQRMFRIGKREFPENLRIDGGSDWVGIHRDLAEYSISNEELPQKLRKTFESILLPLESFYHTLAFNSKFCDDLMMSNLRLTNWLRKQGCRCASLKQIVDWCGCSPLVFREDTKIKFEMQKAISKPTYFARKFDSMVDIEAIESAEQQSMSTSKIQMDHPTYHFAYANIFKFGIDEEKIAHRSLASFALNTIKSHEKMAKIVQIDALRAHHNAQIEIVMKVETQSGANFEFLIHRKSHVNLSTSGALEVDGYVLKDVVYGTKFEWKEEICREYMGFVTEKDTLHTRLEWSPTERVKKNDKTSPEIEFQYRNGPEKIDKSIVKPYDSVFGGQFDSWDVGKRLSNLSTCPDFFVDVFSPSSSESPLATLRFSVYTEQNVDCHVAYLRDFFEIVDFCTSETACGEKIWSMSYPDPKSDIQVGWDEEARILR
What is the function of this protein?
Catalyzes the first step in biosynthesis of glycosaminoglycan.  Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein.  Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
What are the official names of this protein?
Xylosyltransferase sqv-6, Peptide O-xylosyltransferase, Squashed vulva protein 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family. XylT subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SYA_CAUVC
Sequence: MPSLNEIRSTFLDYFGKADHAVTPSAPLVPQNDPTLLFVNAGMVPFKNVFTGAETPAHPRAASSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEQAILHAWTLLTAEFKLPKDKLLVTVYHTDDEAADLWKKIAGLGDDRIIRIPTSDNFWSMGDTGPCGPCSEIFFDHGPHIAGGPPGSPDEDGDRFIEIWNLVFMQFEQLAGGERISLPKPSIDTGMGLERIAAVLQGQHDNYDIDLFKALIAASVELTGVKAEGAQAPSHRVIADHLRSSSFLLADGVSPSNEGRGYVLRRIMRRAMRHAYLLGASEPLMHRLAPTLVREMGQAYPELRRAEALIVETLRQEEERFRTTLGRGMGLLDEATANLAAGGVLDGETAFKLYDTYGFPLDLTQDAVRAKGLTVDTDAFDAAMQKQREMARANWAGSGQQGAAAAWFSIKEKAGATDFVGYETTETTGVVKAIVVDGAEVESASAGQTVEVLLDRTSFYAESGGQAGDTGVIEAHGRESRVLDTQKQAGELHVHRVELASDLKVGDQVVASVDADRRNTTRSNHSAAHLVHAALHHVLGPHVAQKGQMVDGERMRFDFSHGGPLTAEELDRIEAEVNEVIRQNVPAETKEMAPQEAIEAGAVALFGEKYGDSVRVLTLGKSLADEAKAYSVELCGGTHVARTGDIALFKIVSEQGVAAGVRRIEALTGEAARRFLLDQAGVAKALADQFKTPVAEVATRVDALIADRKRLEKELAEAKKQLALGGGGAASGPEDVNGTALIARVLDGVGGKELRGVAEEFKKQLASGVVALVGTSDGKAAVTVAVTADLTGKFSAADLAKAAVIAMGGQGAGGKADFAQGGAPDDSKAEEGLAAVKALLAG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEX11_TITSE
Sequence: MKLSCGFLLILLVLSAMIATFSEVEAMKPSKPKCGLCRYRCCSGGCSSGKCVNGACDCSGRSDLNDELEKYQ
What is the function of this protein?
Potassium channel blocker.  At 3 uM, this toxin blocks voltage-independently voltage-gated potassium channels rKv1. 2/KCNA2 (25%), hKv1. 3/KCNA3 (27%), rKv4. 2/KCND2 (25%), Kv10. 1/KCNH1/EAG1 (15%), Kv11/hERG (12%), and Shaker-IR (10%).  On hKv1. 3/KCNA3, the IC(50) is 17. 1 +-3. 3 uM.
What are the official names of this protein?
Potassium channel toxin epsilon-KTx 1.1, Tityustoxin-11, Ts11, TsPep1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Epsilon-KTx 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NU2C2_ORYSA
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFQGSFIFPECILIFGLILLLMIDLTSDQKDRPWFYFISSTSLVISITALLFRWREEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVALECFSLCSYLLSGYTKRDLRSNEATMKYLLMGGASSSILVYGFSWLYGLSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGLGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVAALALATRILDIPFYFSSNEWHLLLEILAILSMILGNLLAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVLSIYYYLKIVKLLMTGRNQEITPYVRNYRRSPLRSNNSIELSMTVCVIASTILGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SSUB_YERPA
Sequence: MTTLTHIPQGTPITLESIGKRYGNRTVLDNLQLRITAGQFVAVVGRSGCGKSTLLRLLAGLEAASDGTLLSGNALLSHAKDETRLMFQEARLLPWKKVIDNVGLGLRGHWRDEALQVLDTVGLADRANEWPAALSGGQKQRVALARALIHRPRLLLLDEPLGALDALTRIEMQGLIERLWQQHGFTVLLVTHDVSEAIALADRVLLIEEGRIGLDLAIDLPRPRRKGSAKLAALEAEVLERVLSPPQGIEASRQGIKASRQGTATSRRVAN
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AP2L4_ARATH
Sequence: MASVSSSDQGPKTEAGCSGGGGGESSETVAASDQMLLYRGFKKAKKERGCTAKERISKMPPCTAGKRSSIYRGVTRHRWTGRYEAHLWDKSTWNQNQNKKGKQVYLGAYDDEEAAARAYDLAALKYWGPGTLINFPVTDYTRDLEEMQNLSREEYLASLRRYPFGRKSSGFSRGIAKYRGLQSRWDASASRMPGPEYFSNIHYGAGDDRGTEGDFLGSFCLERKIDLTGYIKWWGANKNRQPESSSKASEDANVEDAGTELKTLEHTSHATEPYKAPNLGVLCGTQRKEKEISSPSSSSALSILSQSPAFKSLEEKVLKIQESCNNENDENANRNIINMEKNNGKAIEKPVVSHGVALGGAAALSLQKSMYPLTSLLTAPLLTNYNTLDPLADPILWTPFLPSGSSLTSEVTKTETSCSTYSYLPQEK
What is the function of this protein?
Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
What are the official names of this protein?
AP2-like ethylene-responsive transcription factor At2g41710.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DEND3_MOUSE
Sequence: MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQELKHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAGQEEGKIAIWKVE
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) activating Rab12.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form.  Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939).  Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668).  Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330).  Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).
What are the official names of this protein?
DENN domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Note=Transiently recruited to membranes to activate Rab12.