PharMolix/UniProtQA huggingface dataset:
Protein: FUS_NDVM
Sequence: MASRSSTRIPAPLMLTIWIALALGCVRLTSSLDGRPLAAAGIVVTGDKAVNIYTSSQTGSIIIKLLPNMPKDKEACAKAPLEAYNRTLTTLLTPLGDSIRRIQESVTTSGGRRQRRFIGAIIGSVALGVATAAQITAASALIQANQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNNTTQELDCIKITHEVGVELNLYLTELTTVFGPQITSPALNQLTIQALYNLAGGNMDYLLTKLGLGNNQLSSLIGSGLITGNPILYDSQTQLLGIQVTLPSVGNLNNMRATYLETSSVSTTKGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRIVTFPMSPGIYSCLTGNTSACMYSKTEGALTTPYMTLKGSVIANCKMTTCRCADPPGIISQNYGEAVSLIDRHSCNVLSLDGITLRLSGEFDAAYQKNVSILNSQVIVTGNLDISTELGNANNSISNALNKLEESNSKLDKVNVRLTNTSALITYIVLTVISLVCGILSLVLACYLMHKQKAQQKTLLWLGNNTLDQMRATTKA
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: HSCB_AROAE
Sequence: MSIDLQQDFFALFGLPRRFRVDEAALEMAYHDLQGQVHPDRFAHLPDVEKRLSMQWATRVNEGFRTLRKPLPRAQYMLELAGVDAGLHTNTAMSSAFLMEQMEWREAVEEARAAGEGHELTQLHHRLRHHAREVFDELERTIDERHDFAAAAEIVRRLMFMEKIQHEIDDALEALET
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: DAPF_PHOLL
Sequence: MQFSKMHGLGNDFMVVDAVTQNVYFSPELICRLADRHTGVGFDQLLIVEAPYDPDMDFHYRIFNADGSEVAQCGNGARCFARFVRLKGLINKRDIKVSTQSGRMVLSITNDDQVCVNMGEPEFEPHHVPFRALRAEKTYILRVAERTVLCGVVSMGNPHCVIQVPDVETAEVDILGPALESHERFPERANIGFMQILNRGHIRLRVYERGVGETQACGSGACAAVAVGIQQQLLDNHVRVDLPGGSLFICWDGPGKPLYMTGPAMHVYDGTIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_MYCSS
Sequence: MGRFDDAGAQDAEPDDRDVSPALTVGEGDIDASLRPRSLGEFIGQPRVREQLQLVLEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELSSSLRVTSGPALERAGDLAAMLSNLVEGDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIHLGTEAGAEIARRSRGTPRIANRLLRRVRDYAEVRADGVITRDIAKAALEVYDVDELGLDRLDRAVLSALIRSFGGGPVGVSTLAVAVGEEPTTVEEVCEPFLVRAGMIARTPRGRVATASAWTHLGLTPPSGITGLGQTGLFD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ATPA_CHLSC
Sequence: MVTMRADEISNIIRERIEQYNREVKVVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEISAYESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQNVICVYVAIGQKASSVAQVVTTFQERGAMEYTIVVAEMADSPATLQYLAPYTGAALAEYFMYRERHTSIIYDDPSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSRLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIVTIYTGANGYLDSLEIGQVKKFLVQLRTYLKTNKPQFQEIISSTRTFTEQAEALLKEIIQEQIELFLLQEQT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PSBL_AGRST
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ECCB3_MYCTO
Sequence: MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTGWRFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAGSNAVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIGIPGAPERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQAVLVDSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPLTAPIIPDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLAAILRNNNSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSKPVGAATSSLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPDAPGAGSLFWVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPTLSRADALLAHDTLVPDSRPARPVSAEGGYR
What is the function of this protein?
An ATPase (By similarity).  Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
What are the official names of this protein?
ESX-3 secretion system ATPase EccB3, ESX conserved component B3, Type VII secretion system protein EccB3, T7SS protein EccB3.
What is the protein family that this protein belongs to?
Belongs to the EccB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MDM12_PENRW
Sequence: MSIEVDWAAATSGPDGEALAERIRSFVHDKFQEITLPRFIRSVQVHSFDFGTIAPDLEVKDICEPFADFYEEEADDADTSVASEELGHELHESPYEDDMTYNPTAHNLHSFSHHPYPGEGFQPSALRSPLGDHLNPHFMPRASTPGIPGGTSTLGYHMRSLGGLSGTQTPLAAVAGGTSFASGWSDSGMGVGPRSQAARPAGPHHLAEPDLDTTNSTSRPSTANTLPSHPSLGHSGSSGSNPHTSDPTDAPQPSIETSDDPAAEGHSLPIPPRMRERRPEDFQVLCHAKYAGDVRMSLTAEILLDYPMPSFVGLPLKLNVTGITFDGVAVVAYIRKRVHFCFLSAEDADALLGSEQSQGSQNPSDDGRPRSGGDQKDKELKRQGGLLQEIRVDSEIGRKEDGKQVLKNVGKVERFVLAQVRRIFEEELVYPSFWTFLV
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.  The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: HIS6_SHIF8
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVEEVQKRGAGEIVLNMMNQDGVCNGYDLKQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD11B_HUMAN
Sequence: MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
What is the function of this protein?
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis.  Involved in pre-mRNA splicing in a kinase activity-dependent manner.  Isoform 7 may act as a negative regulator of normal cell cycle progression.
What are the official names of this protein?
Cyclin-dependent kinase 11B, Cell division cycle 2-like protein kinase 1, CLK-1, Cell division protein kinase 11B, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L1, p58 CLK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1689_STRP3
Sequence: MLGIITFIIIFGILVIVHEFGHFYFAKKSGILVREFAIGMGPKIFSHVDQGGTLYTLRMLPLGGYVRMAGWGDDKTEIKTGTPASLTLNEQGFVKRINLSQSKLDPTSLPMHVTGYDLEDQLSITGLVLEETKTYKVAHDATIVEEDGTEIRIAPLDVQYQNASIGGRLITNFAGPMNNFILGIVVFILLVFLQGGMPDFSSNHVRVQENGAAAKAGLRDNDQIVAINGYKVNSWNDLTEAVNLATRDLGPSQTIKVTYKSHQRLKTVAVKPQKHAKTYTIGVKASLKTGFKDKLLGGLELAWSGAFTILNALKGLITGFSLNKLGGPVAMYDMSNQAAQNGLESVLSLMAMLSINLGIFNLIPIPALDGGKILMNIIEAIRRKPIKQETEAYITLAGVAIMVVLMIAVTWNDIMRVFF
What are the official names of this protein?
Putative zinc metalloprotease SpyM3_1689.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOG_RICCN
Sequence: MIKLNVDGSEIEVSEGSTVYQACTQAGKEIPHFCYHQRLKIAGNCRMCLVEMEKSPKPIASCAMPVSNGMVIHTDTPMVKKAREGVMEFLLINHPLDCPICDQGGECNLQDQAFRYGKGTNRFHENKRSIKDKYMGPLIKTAMTRCIQCTRCIRFASDIAGIEEIGAIHRGEHIEVTSYLEQTLDSEISGNMIDICPVGALNSKPYAFKARKWELKHTASIGVHDAEGSNIRIDSRGDEVMRILPRVNEEINEEWLSDKNRFSYDGLKYQRLDRPYIRKNGKLVEASWSEALKTVADKIKSVKPEKIVAIAGSLSSVEAMFMLKTLLQKLGSNNYSVNQFDYKLDTMQRGNYLFNTTIAGIEKADLCLLIGANPRQIAPVLNSRIGMRVRADSLKVARIGGGHNQTYKIQDLGSDIKIIEELAIGTHEFTKALKAAKYLMIIVGDGVYARDDGYAILSLIHKIVTEYNIMRDDWKGFNILHNHASIVGGLDIGFNTPIKLEELELAYLLGTDAIPFDKLKSTFIIYQGHHGDAGASSADVILPAAAYTEQSGIYVNLEGRPQIAEKAVSPVGVAKEDIEIIKELAGYLKIDIGMDNLQEVRVRLAKEYKVFASIDRIIENKFSKFSSKDKLSKEPITAEPINYYMTDVISKNSVTMAKCVEAKEARDEEVA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit G, NADH dehydrogenase I subunit G, NDH-1 subunit G.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
Protein: HEM1_RHOBA
Sequence: MTLKMIGCSHHDAAVEIREQLSFTENEINRTFELFGQRFADAELVLLSTCNRVELYGAGSNPASLQSDDLIDLVADCLNQSRDFVANHMIIREGREAVEHLFLVAASLDSMVVGEAQILSQVKQSYDLANDADRTGPITHGVFQAANRTAKRVQTETSIHRRRLSVPSVAIGEVVPEVFNRLQGKRVVLCGAGEMAEETLRYLKNGGANNLCVVNRSLDRAQKLADEFGADAESMDSLHDQIVQADLLIGTTSAEEPIVDASTFAALNAKRGGRIMLVLDLAVPRDFDPVIGDEPGVYLYQIDDLQAACNRNRREREKQWPKAKKIIDEEVDGFFQSLQQRATGPVIRRLRERADKVKAEELQRLFGKLNGSTDTAMQKEIEKSFDRLTNKLLHPPMASLRDDAADGHSRGLLEALRHLFNLGEDS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TXLC_CYRSC
Sequence: MKTSMFLTLTGLVLLFVVCYASESEEKEFPKELLSSIFAADSDFKVEERGCLGDKCDYNNGCCSGYVCSRTWKWCVLAGPWCR
What is the function of this protein?
Agglutinates erythrocytes.
What are the official names of this protein?
U5-theraphotoxin-Hs1c, U5-TRTX-Hs1c, Lectin SHL-1a1, Lectin SHL-Ia1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS13_ACIB3
Sequence: MARIAGVNIPDNKHAVISLTYIFGIGRHTAKNILAAVGITETTKIRELDDAQLDAIRAEVAKVPTEGDLRREISMNIKRLMDLGCYRGLRHRRSLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PTR2_YEAST
Sequence: MLNHPSQGSDDAQDEKQGDFPVIEEEKTQAVTLKDSYVSDDVANSTERYNLSPSPEDEDFEGPTEEEMQTLRHVGGKIPMRCWLIAIVELSERFSYYGLSAPFQNYMEYGPNDSPKGVLSLNSQGATGLSYFFQFWCYVTPVFGGYVADTFWGKYNTICCGTAIYIAGIFILFITSIPSVGNRDSAIGGFIAAIILIGIATGMIKANLSVLIADQLPKRKPSIKVLKSGERVIVDSNITLQNVFMFFYFMINVGSLSLMATTELEYHKGFWAAYLLPFCFFWIAVVTLIFGKKQYIQRPIGDKVIAKSFKVCWILTKNKFDFNAAKPSVHPEKNYPWNDKFVDEIKRALAACKVFIFYPIYWTQYGTMISSFITQASMMELHGIPNDFLQAFDSIALIIFIPIFEKFVYPFIRRYTPLKPITKIFFGFMFGSFAMTWAAVLQSFVYKAGPWYNEPLGHNTPNHVHVCWQIPAYVLISFSEIFASITGLEYAYSKAPASMKSFIMSIFLLTNAFGSAIGCALSPVTVDPKFTWLFTGLAVACFISGCLFWLCFRKYNDTEEEMNAMDYEEEDEFDLNPISAPKANDIEILEPMESLRSTTKY
What is the function of this protein?
Uptake of small peptides.
What are the official names of this protein?
Peptide transporter PTR2, Peptide permease PTR2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PANB_LEGPL
Sequence: MKIHDFKIKKQEQKKISMLTCYDYPSACIVAESNIDCVLVGDSVAMAVHGYPTTIMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKIQGKNSEQAETLLQQATTLEQAGCFAVVIECVPQDLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAFL_HUMAN
Sequence: MDNMSPRLRAFLSEPIGEKDVCWVDGISHELAINLVTKGINKAYILLGQFLLMHKNEAEFQRWLICCFGATECEAQQTSHCLKEWCACFL
What is the function of this protein?
May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
What are the official names of this protein?
Barrier-to-autointegration factor-like protein, BAF-L, Barrier-to-autointegration factor 2.
What is the protein family that this protein belongs to?
Belongs to the BAF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: THOC6_HUMAN
Sequence: MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF
What is the function of this protein?
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.  TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.  The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.  Plays a role in apoptosis negative control involved in brain development.
What are the official names of this protein?
THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58.
What is the protein family that this protein belongs to?
Belongs to the WD repeat THOC6 family.
Protein: RL22_BACCZ
Sequence: MQAKAVARTVRIAPRKVRLVVDLIRGKQVGEAIAILNHTPKTASPVVEKVLKSAIANAEHNYEMDINSLVVEKVFVDEGPTLKRFRPRAMGRASQINKRTSHITVVVSEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NS2_HRSV1
Sequence: MSTTNDNTTMQRLMITDMRPLSMESIITSLTKEIITHKFIYLINNECIVRKLDERQATFTFLVNYEMKLLHKVGSTIYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response.  Acts cooperatively with NS1 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3.  Interacts with the host cytoplasmic sensor of viral nucleic acids RIGI and prevents the interaction with its downstream partner MAVS.  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C.  The degradasome requires an intact mitochondrial MAVS.  Induces host SOCS1 expression.  Induces activation of NF-kappa-B.  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism promoting continued viral replication.
What are the official names of this protein?
Non-structural protein 2, NS2, Non-structural protein 1B.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 2 family.
What are the subcellular locations of this protein?
Host mitochondrion. Note=Most NS2 resides in the mitochondria as a heteromer with NS1.
Protein: MD31A_XENLA
Sequence: MAATMETDEQQRIRFQLELEFVQCLANPNYLNFLAQRGYFKDKPFVNYMKYLLYWKEPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRVRLQQALAEQQQQNNTSGK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31-A, Mediator complex subunit 31-A, Mediator complex subunit soh1-A.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COX19_CANAL
Sequence: MATGAPGGNFRTWTPTPPERGSFPLDHDGECKEYMTKYLTCMKFTENKNAPNCRILAKQYLKCRMDNQLMEKSDWDSLGLVNLPGENDVELDHHHHLNNNNTKADGKSGSSNSNQNLANTTNNNTGTSSGTK
What is the function of this protein?
Required for the assembly of mitochondrial cytochrome c oxidase.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX19.
What is the protein family that this protein belongs to?
Belongs to the COX19 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.