PharMolix/UniProtQA huggingface dataset:
Protein: RL1_STRS7
Sequence: MAKKSKQMRAALEKVDSTKAYSVEEAVALAKETNFAKFDASVEVAYNLNIDVRKADQQIRGAMVLPNGTGKTQRVLVFARGAKAEEAKAAGADFVGEDDLVAKINGGWLDFDVVIATPDMMAIVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQAIIGKVSFDADKLVENFKAFHEVMVKAKPATAKGTYMTNVSITTTQGVGIKVDPSSF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RL28_ANAD2
Sequence: MARRCEICGKGPLVGNTVSHANNKNKTRSLPNLRSVRANLAGEIRHIRVCTRCLKAGKVVKAGRGRPTASAQA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: HLDE_EDWI9
Sequence: MKVTLPDFRRAQVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVETIEERPGGAANVAMNIASLGASARLVGLTGVDDAARALSTRLDEVHVECDFVAIPAQPTITKLRVLSRNQQLIRLDFEEGFGGVDPGPILARIRQALPQVGAVILSDYAKGALASVQAMICLARDAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGRCHSEQEIVDRGLALMERFDLTALLVTRSEQGMTLLQRGIAPLHMPTQAQEVYDVTGAGDTVIGMLAASIAAGASLDEACFLANAAAGVVVGKLGTSTVSPIELENAIRGRADTGFGVMTQEELKTAVLQARQRGEKVVMTNGVFDILHAGHVSYLANARRLGDRLIVAVNSDASTSRLKGPERPVNPLVQRMLVLAALEAVDWVIPFEEDTPQRIIAEILPDLLVKGGDYKPEEIAGGKEVIAAGGEVRVLNFEDGCSTSNIINIIRQGQND
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: CIA2A_MOUSE
Sequence: MERVSGLLSWTLSRVLWLSGFSEHGAAWQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVTESCVEVQEINEDDYLVIIKFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD
What is the function of this protein?
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004).  As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004).  May play a role in chromosome segregation through establishment of sister chromatid cohesion.  May induce apoptosis in collaboration with APAF1 (PubMed:25716227).
What are the official names of this protein?
Cytosolic iron-sulfur assembly component 2A, MIP18 family protein FAM96A.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST6B1_MOUSE
Sequence: MADKSKFIDYIDDALEKSKETTLSQLFLTYQGIPYPVTMCTQETFRALDAFEARSDDVLLASYPKCGSNWILHIVSELIFAVSKKKYACPEFPVLECGDAEKYQRMKLFPSPRILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDDENVKFILYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAIGPFLFRKGEVGDWKRLFNETQNQEMDERFKECLAGTSLGDKLKYEAYCLA
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine.  Involved in the metabolism of thyroxine.
What are the official names of this protein?
Sulfotransferase 6B1, ST6B1, Thyroxine sulfotransferase.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NHAA_SALPB
Sequence: MKHLHRFFSSDASGGIILIIAAALAMLMANMGATSGWYHDFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIGLEVKRELMQGSLASLRQAAFPVIAAIGGMIVPALLYLAFNYSDPVTREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIVIIALFYTSDLSIVSLGVAAFAIAVLALLNLCGVRRTGVYILVGAVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPAKRLEHVLHPWVAYLILPLFAFANAGVSLQGVTIDGLTSMLPLGIIAGLLIGKPLGISLFCWLALRFKLAHLPQGTTYQQIMAVGILCGIGFTMSIFIASLAFGNVDPELINWAKLGILIGSLLSAVVGYSWLRARLNAPA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UL63_HCMVA
Sequence: ISHQYHERPIALYTNLVILGQPPEKPTRDRAGAARTSRPIPPPVGDLHLFGKKLISLYVTYIYYTLCTPNCRCCIRRKNSPYLYRLNFCLIDTCLELCPPTFSLCITKICVSQKILRCLKTGETCVWVL
What are the official names of this protein?
Uncharacterized protein UL63.
Protein: SYFB_SYNSC
Sequence: MRVSISWLKQLVQVNESVDDLSERLSMAGFEVDDVDDLSARAQGVVVGNVLEREKHPNADKLSVCKVDVGAQAPIQIVCGASNVRSGIHVPVAMVGATLPAVGLTIKAGELRGVASNGMICSLTELGLTEQSDGIAILDELDESLPPNGSPVAPLLGLDDTVLELAITANRPDGLSMVGIAREVAALTGGSLSLPELDLDPSTSPLTTELDGCFYTITRIEGVDGSKPSPTWLQQRLERGGVNSVNAVVDVTNLVMLEQGQPLHAFDADALEQLTGQPVDAKSFAVRSARDGEIFVGLDDQKRTLDSRVQVVTCHDRPVAVAGVMGSLESGVTASTRNIWLESALFAPPRVRHSARALGLRTDASSRFEKGLPVEMTLPCSARASALLSQEFSCSESGRWVGGSGPAEAGPVLLRRSALHQLLGPLDAADGPEDLDDTSIENCLTALGCQLSAHEQGWEVMAPPSRRQDLQREVDLIEEVARLVGFDRFGAHLPDPLEPGALTPRQQAERRLRQLFCATGLQEVTTLSLVPASEQEQRIAISNPLLADTSHLRTNLWEEHLQICVRNLKASQRGCSVFEIGNTYSGSPEAVSQKAVLAGVICGDRRLSTWATSGKPQAPDYFQARGVLTRVMEALQLELSDRRLTDDARLHPGRAATLVLEGRPLGCFGQLHPAMAEELDLPEATYLFELDLARLLDAATRSNRWTPSFKPYPTVPFSERDLAVIVDRSSAATDLIQAIRKAGKPLLEQVELVDRFEGEQLGDNKVSQAFRLRYRGKNETLTDDKIQPVHDKVRAALSKQFQAELRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBD_PLAOC
Sequence: MTIALGRFTKDENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RRP5_SCHPO
Sequence: MAGNKRKRSNASEGSDSQGNERISSLSANEATQDFPRGGASSLTPLEYKEAVLEAKKDFMESASGTAELSKKTRPKKKGSKKSSKSELDNEENLKVHIQSLRYKNITPGSLILGQIAQINTLDLAVSLPNCLTGYVPITNISDKLSDRLDSIDNHAEDNAATEEEDGLNQIPDLMDLYKVGQWVRVSVTALGSENTTKTGKRHIELSLKPQDANGSAPEAADFVAGSMIQAVVSSIEDHGIVFDIGINNYTGFLSKKHINDFPFVEGQSLLCSVISKEDRIFHLSLTATSTKALEVMPSVQAILPGDYINVLVTDIKESGVIAKYMGVVDVTSDIYHSSPVKGEDLEDKFQLAKSVPARVLFVIPGDPPKIAVSFLPHVLTFNFATPNTPHPDQLDIGFIVNAAKVTYVSSSLGVFCDVGVPEISGFAHISRLSDKKVAGISPNSGPYKVDSTHEARIINYSYVDNLYILSFQQSVLNQQFLRIEDIEVGQFVDGTIAKLIPQGIVVTISEGINGLVPSTHMADIALQFPERRFKVGSSVKCRVLSTNVLRKRVLLTLKKSLLNTDLPLIYDYEQATPGTQTVGTLARIFEDGAIVEFYNSVRAFLPVSEMSEAYIRDAREHFKVGQTLSVTIVSCDPENRKMRVGCREQSWDAKRLERFENIKAGSVLSGIVLQKTEDSVIVDLGDKVTGVITLGQLCDGDLNKCSKVMNKLRASTKLAEVLVLRKDTSKKLISLSLKKSLVEAAKENRMPINITDLKEGIKYFGFVRNATTFGVFVEFCDGLVALVPKAYISEEYVPVPSAVYKPQQSVTCVCLSVELSQEKAFMSFKPLAQKQEKAVEFMESKYDIDNPVDETIKKTYDYVAGKITWAVVTSAKASQLNVDLAANVHGRVDVSEVFDNFGEIVDPNKPLKRFHKGDKIRVRVLGIHDSRNHKFLPISHRVSPKQFLELSVRPSILNMEPFSMKEPQFKKGDEVTGFVNNVSKECVWVSLTPSVNGRIPILDLTTDVKELNSLQKHFFLGKAIKCYVVNAEDSITLSAIGPLQGFENLTPGSRLVGKVTNVNEAGAILQLPGHMSGRVSRIDMFDDYDILPETKFTRNNLVGVCVLSVDVPNRKVALSARNSRTQSQPVEIKDKEINSVDDLKIGDICRGFVCNVANQGLFVTIGHNLIARVKIGELFDTFIKDWKPHFHVNQLVKGSIVGIDNDSKRIEMSLKQSKIKDSSEITKTFADIAVGSNLDGTVVKVGDYGVLIRIDGTDNIVGLCHKSEIADAVVLNISKLYSSGDKVRAHVLDVDSEKRRIALGLKSSYFDSDSDISMSDNEEDVEMRSEDQSDTSESEVGSKDDVQSEEVENLESAGDEDEEEEPSALQANGFDWTDGSTVFDKLADDTEDSEDEEDEEPKRKKSKSDRFDDEEKDLDEIPSTAADFERQLLSSPNSSLLWISYMAYHLNLNELQEAREVGKRALSTINYREEDEKLNVWMALLNLEVAYGTEDSLKEVFKEACAYCDALIVYEKLCGILIKGGKVDLADEYMQLMLKNFKQVPSVWIQYATFLLNNDKAEKAHGLLERSLQSLPKSEHVGIIEKFAILEFKNGDPERGRTIFEGLLSSYPKRLDLWNVLIDMEMKQDDPSIVRRLFQRLLALNLSTKKAKFAFKKWLAYEKNIGDDEGAEQVKRRAIEYVSESHSEN
What is the function of this protein?
Involved in the biogenesis of rRNA.  Required for the formation of 18S and 5. 8S rRNA (By similarity).
What are the official names of this protein?
rRNA biogenesis protein rrp5, Ribosomal RNA-processing protein 5, U3 small nucleolar RNA-associated protein rrp5, U3 snoRNA-associated protein rrp5.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BAMA_SALNS
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGNTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVQVSGNLAGHSAEIEKLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNTLRAGLGYVHNSLSNMEPQVAMWRYLASMGQYPSTNDQDNSFSTDDFTFNYGWTYNKLDRGYFPTEGTRINLTGKVTIPGSDNEYYKATLDTATYVPIDNDHKWVILGRTRFGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYYPYNPKNYDADEDYDCATQDGAKDMCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RL19_CLOB8
Sequence: MNEIIRAIEAEQIRTDLPKFAIGDTIKVYVKIQEGNKERVQMFEGTVIKKQNGGLRETFTVRRVAYGTGVERTFPMNAPIIDKIEIARKGKVRRAKLYYLRDRVGKSAKVKELLTR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: HAUS2_HUMAN
Sequence: MAAANPWDPASAPNGAGLVLGHFIASGMVNQEMLNMSKKTVSCFVNFTRLQQITNIQAEIYQKNLEIELLKLEKDTADVVHPFFLAQKCHTLQSMNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHLETIRNIPHLAANLKKMNQALAKMDILVTETEELAENILKWRKQQNEVSSCIPKILAEESYLYKHDIIMPPLPFTSKVHVQTINAK
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 2, Centrosomal protein of 27 kDa, Cep27.
What is the protein family that this protein belongs to?
Belongs to the HAUS2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein: YBEY_GRAFK
Sequence: MEKGEINFFSENDFVLNREQDYRNWIEKAIESENKYIGDISFIFCDDEYLHKINLEYLAHDTYTDIISFDNTLGNTLQGDIYISTERVQENANSFNTEFDEELKRVLIHGILHFCGFKDKTEREQELMRRKEEEKIALFHVEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOT1_COCIM
Sequence: MSFFDHLQKKGVGAIQAQKVQIRKVERKPSKVVSSSSSSSIAKPQRRLDTVSKPVAARRSASSASKPARHPQPRSRPPSRKRNTIEPTLFGSSEESDTDVSLDLRITKRARVSSSVEPDLHRRVRDTDAFSDGEAAFDMIHAADIISSKKSLGFNNAFGIEDGPIIVELQYPGAPQKERYQLVVPRDNDGFKPLDDIVQVLEIVSQNYISEEHLALFEDESNGLLRRLRRALSNTSLTDFLDGVKSYNETIQRLHQDGSISRHLDSKHALALPLVERILTQVYSRTVSPRVDSLRQYENGSDNVYGELLPRLVSKIFAETRLKSDQVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACDLAELQEKEFKTRCRLWGLQPGQTHLKRGDFLEVDSVGKILQKADVVLINNQAFTPELNHKLVNYFLDMKEGCQIVSLKSFVPAGHRIQSRNLNSPINLLSVKQKQYWSDSVSWTNAAGTYFIATKDSSRLKAFLESST
What is the function of this protein?
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3.  This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks.  Nucleosomes are preferred as substrate compared to free histone.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone H3-K79 methyltransferase, H3-K79-HMTase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NIP12_ARATH
Sequence: MAEISGNGGDARDGAVVVNLKEEDEQQQQQQAIHKPLKKQDSLLSISVPFLQKLMAEVLGTYFLIFAGCAAVAVNTQHDKAVTLPGIAIVWGLTVMVLVYSLGHISGAHFNPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDQDVCSGKHDVFVGTLPSGSNLQSFVIEFIITFYLMFVISGVATDNRAIGELAGLAVGSTVLLNVIIAGPVSGASMNPGRSLGPAMVYSCYRGLWIYIVSPIVGAVSGAWVYNMVRYTDKPLREITKSGSFLKTVRNGSSR
What is the function of this protein?
Water channel probably required to promote glycerol permeability and water transport across cell membranes.
What are the official names of this protein?
Aquaporin NIP1-2, NOD26-like intrinsic protein 1-2, AtNIP1;2, Nodulin-26-like major intrinsic protein 2, NodLikeMip2, Protein NLM2.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FBL25_ARATH
Sequence: MEEEDHATFAVGNPSHRFDRPLIRRSSDSISNLPDEILHHILSFIPETNLVIRTSVLSKRWRHVWSKTPHLSFEWLMVSPKLINKTLASYTASKITSFHLCTSYSYEAGHVHSSIEFAMSHNVDNLSLAFSSFPPCNKFPDFFYTSSSLKRVELRSASLTPSCIVSWTSLRDLSLTRCNLSDKSFLKILSGCPILESLSLKFCESLKYLDLSKSLRLTRLEIERRSCFREPMQSMQIVAPHIHYLRLRDSEAHCTFLV
What are the official names of this protein?
F-box/LRR-repeat protein 25.
Protein: VGR1C_PSEAE
Sequence: MAIGQPFATALGCTIIWRAAGALFGPPAAGDYQGRFPMLFSQHTRLVHVDSPLGPEVLQLQRLEGREELGRLFSHELELVSSNPALPLDALLGKPMSLALELPGGSRRYFHGIVARCSQGAGAGQFASYQVTLRPWLWLLTRTSDCRIFQNQKVPDIIKQVFRDLGFSDFEDALSRSYREWEYCVQYRETSFDFVSRLMEQEGIYYWFRHEKKRHILVLSDAYGAHHSPAGYTSVPYYPPSLGHRERDHFFDWHMAREVQPGSLSLNDYDFQRPGTRLEVRSNVGRAHAAADYPLYDYPGEYVQSQDGEHYARTRIEAIQTQYERVRLRGCARGIGAGHLFHLSNYPRLDQNREYLVVGAEYRVVQELYETGNGGGGAQFESELDCIDAGQAFRPLPSTPVPVVRGPQTAVVVGPKGEEIWTDQYGRVKVHFHWDRHDQSNENSSCWMRVSQAWAGKNWGSIQIPRIGQEVIVSFLEGDPDRPIITGRVYNAEQTVPYELPANATQSGTKSRSSKGGTPANFNEIRMEDKKGAEQLFIHAERNQDIEVENDESHWVGHDRTKTIDHDETVHVKHDRTETVDNNETITVHANRSKTVDRNETVRIGMNKTETILMASLQNVGMGRMENVGLGYSLNVGMMMNTVVGLNQSTQVMKKKTLSVGDSYEVSVGGSDDGSKITLDGQSITLGSQRIELTADREILLRCGQSTIRLTPGEIEILSPNVDINC
What is the function of this protein?
Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869).  Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity (PubMed:24794869).
What are the official names of this protein?
Type VI secretion system spike protein VgrG1c.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPE_PSESM
Sequence: MVEAQLVLPAPAKLNLMLHILGRRPDGYHELQTLFQFLDYGDELGFALRQDGVIRLQTDVPGVAHDSNLIVKAARALQKQSGCTLGMDIWLEKRLPMGGGIGGGSSDAATTLLGLNHLWQLGWDEDRLAQLGLTLGADVPVFVRGHAAFAEGVGEILTPVDPEEPWYLVLVPQVAVSTAEIFSDPLLTRDTAPIKVRPVPKGNSRNDCKAAVERRYPEVRNALNLLGKFTEAKLTGTGSCVFGAFPNKAEADKVSALLTETLTGFVAKGSNISMLHRKLQIL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RSMC_ECODH
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSRQMGDNARFSLVATADDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDAEKFWGEYSVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIUH_ECO57
Sequence: MLKRYLVLSVVTAAFSLPSLVYAAQQNILSVHILNQQTGKPAADVTVTLEKKADNGWLQLNTAKTDKDGRIKALWPEQTATTGDYRVVFKTGDYFKKQNLESFFPEIPVEFHINKVNEHYHVPLLLSQYGYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase, Transthyretin-like protein, TLP.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: O52B4_HUMAN
Sequence: MPTVNHSGTSHTVFHLLGIPGLQDQHMWISIPFFISYVTALLGNSLLIFIILTKRSLHEPMYLFLCMLAGADIVLSTCTIPQALAIFWFRAGDISLDRCITQLFFIHSTFISESGILLVMAFDHYIAICYPLRYTTILTNALIKKICVTVSLRSYGTIFPIIFLLKRLTFCQNNIIPHTFCEHIGLAKYACNDIRINIWYGFSILMSTVVLDVVLIFISYMLILHAVFHMPSPDACHKALNTFGSHVCIIILFYGSGIFTILTQRFGRHIPPCIHIPLANVCILAPPMLNPIIYGIKTKQIQEQVVQFLFIKQK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 52B4, Olfactory receptor OR11-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VATC_PYRFU
Sequence: MEISTITMILDTTLVAVFAWVAYKTGSLIWKYTPYSYPNARIRAMEARLLSDQRLLELAESKELENFVVNLEDSDYGKRLSELKSYSVEEIEKALDLSFVDTILLFQKIMPKRVRGFFEVMLEEWDVRNIVNVVKAKITGLPAQDFVIPVGKILNKVKAMVEAKTMEEILVILEGTEYEEPVRKLILKEINLPEFEHLMYSLHYQKLLNYVNSRKGEEKVILSEFVSSLIDSKNISLILRAKASGINAEKLKIMLIPGGSISRNVLEAMISAEDPLMALTELEKTKYAEVVKNSREAVEKGDISTVEKQLRRYIQQRMKEQSQFYPLSVAVALSYMLQKENEIRKLKAIVRLIADRVRPERIKEIVGEVT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit C, V-ATPase subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: ATPD_PELTS
Sequence: MLRGAVAVRYAEALYEIASREKVLPKYKSMVDRVEEELKAVDKVIRENSDLQKLLYHPRITAEEKKDLLQKLFKGKISDVTANFLALLVDRRRETFFGEIVAEFVKLANAGRNIITAQVTSAVELNDQEKGDLNRILVRLTGKKVKTSYAVDPSLIGGVVVRMGDKIIDGSLKTRLASLKERLLAIS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRIM5_CHLTN
Sequence: MASGILVNVKEEVTCPICLELLTEPLSLPCGHSFCQACITANHKESMLYKEEERSCPVCRISYQPENIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADTREEKASWKIQIDYDKTNVSADFEQLREILDWEESNELQNLEKEEEDILKSLTKSETEMVQQTQYMRELISDLEHRLQGSMMELLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLKGMLDMFRELTDVRRYWVDVTLAPNNISHAVIAEDKRQVSYQNPQIMYQAPGSLFGSLTNFNYYTGVRGSQSITSGKLTNFNYCTGVLGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDATYNIEQNENYQPKYGYWVIGLQEGDKYSVFQDGSSHTPFAPFIVPLSVIICPDRVGVFVDYEACTVSFFNITNHGFLIYKFSQCSFSKPVFPYLNPRKCTVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Restricts infection by human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV-mac) and N-tropic murine leukemia viruse (N-MLV) (PubMed:22291694).  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity).
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: UPPP_LEPIN
Sequence: MNPYLNAFLRSIIEAITEFLPVSSTGHLFLFSSFFPFYGENVEFDDLFDIFIQSGAILSVLFLYREKFKSQIVSSFRYILKQNSDSEGFHFLIQICIGAFPILIAGFIAKKFLDTIKARPDLLEILSGAWIFGGVLILVAEWYFHQRPEEKKSIGFKDSILIGIFQCMALIPGMSRSAATIITARFLGKDTKSSAEFSFFLAVPVLLAAGIYKLIKYRSILNGNTIPVLMFGFLVSFLLCTLVIRWFLRYIQKHSFSVFGVYRILLGVGVLVLTKLI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.