PharMolix/UniProtQA huggingface dataset:
Protein: ATRF2_STAAR
Sequence: MTEKEKMLAEKWYDANFDQDLINERARAKDICFELNHTKPSDKNKRKELIDELFQTTTDNVSISIPFDTDYGWNVKLGKNVYVNTNCYFMDGGQITIGDNVFIGPNCGFYTATHPLNFHHRNEGFEKAGPINIGSNTWFGGHVAVLPGVTIGEGSVIGAGSVVTKDIPPHSLAVGNPCKVVRKIDNEVPSEALNDETLN
What are the official names of this protein?
Putative acetyltransferase SAR2635.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: CH10_DINSH
Sequence: MAFTPLHDRVLVRRVESEEKTAGGLIIPDSAKEKPAEGLVIAVGAGAKDDDGDRIPMDVKEGDKILFGKWSGTEVTVDGEELLIMKESDILGIITDEAAAKAA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBB1_SOYBN
Sequence: MVVLKVCLVLLFLVGGTTSANLRLSKLGLLMKSDHQHSNDDESSKPCCDQCACTKSNPPQCRCSDMRLNSCHSACKSCICALSYPAQCFCVDITDFCYEPCKPSEDDKEN
What is the function of this protein?
Inhibitor of trypsin and of chymotrypsin.
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor, BBI.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: DAPB_HAEDU
Sequence: MLRIAIVGAGGRMGRNLIQAVQQTEGLSLMAAFEREGSSLIGTDVGELVGISPLGITISACLAEKTADFDVLIDFTRPEATLEYLKFCLANDKKIVIGTTGFDENGKQAIKQASQKIAIVFASNYSVGVNLVFKLLEKAAKVMGNYCDIEIIEAHHKHKVDAPSGTALSMGEHIAKTLGRDLKTDAVFERYGIMDERQTNQIGFATIRAGDIVGEHSVWFVDEGERVEISHKATSRMTFAKGAVCAAQWLANQPQGLFDMTNVLALDQL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YP159_YEAST
Sequence: MATLDFTTKPLALVIYMSVVLLLMVGVPLLFSS
What are the official names of this protein?
Uncharacterized protein YPR159C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLNB_SHIFL
Sequence: MKKIDAIIKPFKLDDVREALAEVGITGMTVTEVKGFGRQKGHTELYRGAEYMVDFLPKVKIEIVVPDDIVDTCVDTIIRTAQTGKIGDGKIFVFDVARVIRIRTGEEDDAAI
What is the function of this protein?
P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA.  When P-II is uridylylated to P-II-UMP, these events are reversed.  When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II 1.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: DDL_THEP1
Sequence: MRVALLMGGVSREREISLRSGERVKKALEKLGYEYTVFDVKEDFLKEVDQLKSFDVVFNVLHGTFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLATYRFLKDIVEIPDFIEIREFMETSPLGYPCVVKPRREGSSIGVFICESDEEFQHALKEDLPRYGSVIVQKYIPGREMTVSILETEKGFEVLPILELRPKRRFYDYVAKYTKGETEFILPAPLNPSEERLVKETALKAFVEAGCRGFGRVDGIFSNGRFYFLEINTVPGLTETSDLPASAKAGGIEFEELVEIILKSAFLKGEVRA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPGP_AERPE
Sequence: MEARPCSGVIFTDLDNTLVGPGGEAGEAGEVYLEALDLGYRVVPVTSKSIYEIVELWDSIGVPPGERIALAESGGAIYGPRGSLARPTGFNSEVGLEYTALGKPLASIDALLDSLAETCGAVRLSKADATEAQLITGLPRERAALAARREYLEVIWSRSQECLDTILSTALRYRELTYVHRAPRTVQIAAHRGKGMAIDAALQEPLLRPCAKVVVTAGDSSHDIPIIERGMLAFRVDYNRDWSRLVKPIYMVIPYEAPKAWTMLIETVKTRSNTPSL
What is the function of this protein?
Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG).
What are the official names of this protein?
Mannosyl-3-phosphoglycerate phosphatase, MPGP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MPGP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DFFB_BOVIN
Sequence: MSAVLRKPKTFKLRSLHSEKKFGVAGRSCEEVLRKGCQRLQLPIPGSRLCLYEDGTELTGDYFWSAPDNSELVLLTAGQTWQGFVSDISRFLSVFQEPHAGVIQAARQLLWDERAPLRQKLLADLLGTVSENIAAETRAEDPPWFEGLESRFRSKSGYLRYSCESRIRSYLREVTSGASLVGAEAREEYLRLVGSMQQKLQAAQYNSSYFDRGAKAGRRLCTPEGWFSCQGPFDVDDCTSRHSINPYSNRESRVLFSTWNLDHVIEKKRVVVPALAAAVHDAEGREVDWEYFYRLLFTLENLKLVHIACHKKTTHKLHCDPSRVYCTPAAPRRKRHARHRL
What is the function of this protein?
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis.  Degrades naked DNA and induces apoptotic morphology (By similarity).
What are the official names of this protein?
DNA fragmentation factor subunit beta.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RP54_BRADU
Sequence: MALTQRLEFRQSQSLVMSPQLMQAIKLLQLSNLDLMTFVEEELECNPLLERASDDAAGAEAPTEVDQVSGDQLAEAQVRDARDGAMTTYTEWGGGGSGDEDYNLEAFVASETTLSDHLAEQLSVAFTAPAQRMIGQYLIDLVDEAGYLPPDLGQAAERLGATQEDVEHVLAVLQEFDPPGVCARNLRECLAIQLRELDRYDPAMQALVEHLDLLAKRDIASLRKLCGVDDEDIADMIDELRRLSPKPGMKFGSARLQTMVPDVYVRPAPDGGWHVELNSDTLPRVLVNQTYYSKLSKKIGKDVDKSYFNDALQNATWLVRALDQRARTILKVATEIVRQQDGFFTLGVAHLRPLNLKAVAEAIQMHESTVSRVTANKYMATNRGTFELKYFFTASIPSADGGEAHSAEAVRHRIKQLIESEEPSAVLSDDAIVERLRVSGIDIARRTVAKYREAMRIRSSVQRRRDNMWSTMNSRASGGTGLDK
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the nitrogen fixation genes.
What are the official names of this protein?
RNA polymerase sigma-54 factor 1.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: PSAB_SORBI
Sequence: MELRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFESWIQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGAAGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSTLSLIGGWLHLQPKWKPSLSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPGSRGEYVRWNNFLDVLPYPQGLGPLLTGQWNLYAQNPDSSNHLFGTTQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFIFLIAGHMYRTNFGIGHSIKDLLEAHTPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTTYGFDILLSSTNGPAFNAGRNIWLPGWLNAVNENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: RL23_SYNS9
Sequence: MTERFQSRLADVIRRPLITEKATRALELNQYTFEVDHRAAKPDIKAAIEQLFDVKVTGISTMNPPRRSRRMGRFAGKRAQVKKAVVRLAEGNSIQLFPES
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MNME_STAA3
Sequence: MDLDTITSISTPMGEGAIGIVRLSGPQAVEIADKLYKGKHLLNDVPSHTINYGHIIDPESKEVIEEVMVSVLRAPKTFTREDIIEINCHGGILTINRVLELTMTYGARMAEPGEFTKRAFLNGRIDLSQAEAVMDFIRSKTDRASKVAMNQIEGRLSDLIKKQRQSILEILAQVEVNIDYPEYDDVEDATTEFLLEQSKEIKQEINRLLDTGAQGKIMREGLSTVIVGKPNVGKSSMLNNLIQDNKAIVTEVAGTTRDVLEEYVNVRGVPLRLVDTAGIRETEDIVEKIGVERSRKALSQADLILFVLNNNEALTQEDYTLYEVVKNEDVIVIVNKMDLEQNIDINEVKDMIGDTPLIQTSMLKQEGIDELEIQIRDLFFGGEVQNQDMTYVSNSRHISLLKQARQTIQDAIDAAESGVPMDMVQIDLTRTWEILGEIIGETASDELIDQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUB1_HUMAN
Sequence: MAQKKYLQAKLTQFLREDRIQLWKPPYTDENKKVGLALKDLAKQYSDRLECCENEVEKVIEEIRCKAIERGTGNDNYRTTGIATIEVFLPPRLKKDRKNLLETRLHITGRELRSKIAETFGLQENYIKIVINKKQLQLGKTLEEQGVAHNVKAMVLELKQSEEDARKNFQLEEEEQNEAKLKEKQIQRTKRGLEILAKRAAETVVDPEMTPYLDIANQTGRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALPCLLDADKYFCECCRELLDTVDNYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQKCFKNCYGENHQRLVHIKGNCGKEKVLFLRLYLLQGIRNYHSGNDVEAYEYLNKARQLFKELYIDPSKVDNLLQLGFTAQEARLGLRACDGNVDHAATHITNRREELAQIRKEEKEKKRRRLENIRFLKGMGYSTHAAQQVLHAASGNLDEALKILLSNPQMWWLNDSNPETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNGGSLPPELPLSPEDSLSPPATSPSDSAGTSSASTDEDMETEAVNEILEDIPEHEEDYLDSTLEDEEIIIAEYLSYVENRKSATKKN
What is the function of this protein?
Specific down-regulator of the NEDD8 conjugation system.  Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation.  Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
What are the official names of this protein?
NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly nuclear.
Protein: Y6459_MYXXD
Sequence: MNLKSLSLQELEAALAPLSPSPAAVRKVFAAVFAHGAQSVEDVASARQVPRRVGDHLRAHAEMPKLAIVERRRADDGFVKYLFDSPLGGRIEAVRIPIFDEKYVICVSSQVGCALACDFCMTGKLGFKRNLQTWEILDQVLQVREEADRPVRGVVFMGMGEPLLNYKETLRAADILRHPAGFSIAGEAITFSTAGHVPAIRRYVREGHPYRLAFSVTSAIAEKRAKVLPIEKTHPLPELIAAIREYSEVRRERAMIAYVAISGFNMGREDAEALKVAFEGIRIKVDLIDVTDPTGKYLPPTPEELSAFRDHLQILKSPVARRYSGGKEIGAACGTLAATQYGGTVMPRPAEAPPSTTP
What are the official names of this protein?
Probable RNA methyltransferase MXAN_6459.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_BACCQ
Sequence: MSQSLIVALDFPGKQDVEQFLRHFEGEELFVKVGMELFYKEGPAIITYLKEKGHKIFLDLKLHDIPNTVKSAMRSLASLDVDMVNVHAAGGNSMMKAAIEGLEEGKQEGKERPICIAVTQLTSTSEAMMKKEIGIEKTLEEAVAHYAKLTKESGLDGVVCSTLEVPKLREVCGDGFVTVTPGIRLASDDVNDQVRVATPKRARELGSSYIVVGRSITKAENPLEAYKTVKQQWEGVTV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: Y1767_STRU0
Sequence: MLIYLIPTAKEMSQNHTRFPATFPKKSYPILDVLANLSVKDLSKAYRISEDASQKEWLRIQALYNHTAPTYPAYKLFNGLMYRYLKRDSLSPKEEDYLKNHVYITSALYGIIPASFPIAEHRLDFQTKIKIGQQSLKHFWREDYNQFIDANQTYVSLLSSEFEDVFSTDQRQMWISTQFLEEKNGLLKSHSTISKKARGAFLTACIAKQCQSISDLKTLDFIGFSFSPELSTNHKFVYIKKEA
What are the official names of this protein?
UPF0246 protein SUB1767.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RECA_RHOCS
Sequence: MSAASLRLVDTPMDKQKALDAALGQIERAFGKGSIMKLGAREAMAETEAISTGSLGLDIALGIGGLPRGRIVEIYGPESSGKTTLALHAIAEAQKAGGTCAFVDAEHALDPAYARKLGVDVDELLISQPDAGEQALEIADTLVRSGAIDVLVVDSVAALVPRAELEGEMGDSHVGLHARLMSQALRKLTGSISKSRCLVIFINQIRLKIGVMFGNPETTTGGNALKFYASIRLDIRRIGAIKDRDNVVGNQTRVKVVKNKMAPPFRVVEFDIMYGEGVSKVGELLDLGIQAGVVEKSGAWFSYDGQRIGQGRENAKTFLRNNAAVAEAIEAKVRANAGLVASAMMGAPESDGDAASPD
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_BURA4
Sequence: MSASPQSRPTTIACLLGPTASGKTAAALALAARRPIEIVSIDSALVYRDMDIGTAKPTRDERARVPHHLIDIIDPADAYSAAEFRADALRLIGEIAARGRTPLLAGGTMLYYKALTQGLNDLPTADPAVRAELDADAARDGWPALHARLAQVDPATAARLAPNDSQRIQRALEVFLLSGQPMSVLLAAPRRADDEAAAYRFVPVALEPSDRAVLHARIAQRFDAMLDAGFIDEVERLRRREDLHPDLPSMRCVGYRQAWEFLDGDTDYRTMRDKGIFATRQLCKRQITWLRALPERIVVDCVAPDATARALDTLERVLDDHLPA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SYH_NOSP7
Sequence: MAKGDKINFSTPSGFPEFLPSEKRLELYLLDIIRRVFESYGFTPIETPAVERLEVLQAKGNQGDNIIYGIDPILPPNRQAEKDKSGETGKDKSGETGSEARALKFDQTVPLAAYIARHLNELIFPFARYQTDMVFRGERAKDGRFRQFRQCDIDVVARRELSLLYDAQMPAIITEIFEAINIGDFLIRINNRKVLTGFFKSVGITEDKIKSCINIVDNLEKIGESKVKQELEKEGVSGEQTQKIIDFIKIDGSVDEVLDKLKHLTLNLPETEQLSLGISELETVIAGVRNLGVTENRFCIDLSIARGLDYYTGTVYETTLLGHEALGSICSGGRYEELVGVFLGEKMPGVGISIGLTRLISRLLKAGILSTLAATPAQVMVVNMQEDLMPTYLKVSQHLRQAGINVITNFDKRPLGKQFQLADKQGIQFCVIIGSEEAAAQKSSLKDLKSGEQVEVLLVNLAEEVKRRLS
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NARP_ECOLI
Sequence: MPEATPFQVMIVDDHPLMRRGVRQLLELDPGSEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ
What is the function of this protein?
This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.
What are the official names of this protein?
Nitrate/nitrite response regulator protein NarP.
Protein: GCH1_RUMCH
Sequence: MSIDRKKVEEHIRGLLVAIGENPDREGLKETPSRVAQMYQEVFEGISYTNDEIAEMFNKTFEEDLVIPKDNKEIVLVKDIDIFSYCEHHMALMYNMKVAVAYIPNDKILGLSKIARIADMVGKRLQLQERIGSDIAEIMQKITDSEDVAVIVEGQHACMTTRGIKNTGSRTTTTTLRGAFKTDTNLTNRLMMLYK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: MOR2A_MOUSE
Sequence: MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNTAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVETDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPIEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSRLLQPTEAPRKPANPPIKTVPRPTPPVHTPPLSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVSDEEEAEEEAEKRRERCKRGKLAVKEEKKEANELSDSAGEDHPAELRKAQKDKGLHVEVRVNREWYTGRVTAVEVGKNAVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVARQAVALPEPSTSDGLPIEPDTTATSPSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD
What is the function of this protein?
Essential for epigenetic silencing by the HUSH complex.  Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity).  Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365).  Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression.  During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity).  During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity).
What are the official names of this protein?
ATPase MORC2A, MORC family CW-type zinc finger protein 2A, Zinc finger CW-type coiled-coil domain protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Chromosome. Nucleus matrix. Note=Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin.
Protein: CCT12_ORYSJ
Sequence: MDGESQTSKLSCEHMYSWYFTREELEKFSPSRKDGITEIMESEIRQLYCSFIRDVGIRLKLPQMTIATAIMFCHRFYLYQSLAKNGWQTIATVCIFLASKVEDTPCPLDQVIRVAYGTMYRRDPATARRIHQKDVFEKQKALILTGERLVLTTVRFDFNIQHPYRPLLDAMEKLGISQKEVKQVAWNFVNDWLKTTLCLQYKPQYIAAGSLYLAAKFQNVKLPVHGGHVWWHQFDVAPKPLEAVLQQMREMVHMKAKLFAHPSPAKQKEVLFEGMLLISNSPDSVLTQSSLSVSSSSPEIGDPNDHLQVDSSQDIVHIEDRSKSYPERNLSNLTADMNNPGKTHNKESLDQALKIKHGGLISCNQQIPLDAIAKIDSSTAKCVEQNIGICCSSSNTFNGKILNPFSISQRSGDKTKLCSEGGSSLTDVDSKSTQSVEPPTTICNHTSDSLNVDSLCSDQRLANSTAGTTEKASFVLPVQIKVDHLCVERKKVDVARIKDLLMKRKRRRERQGRCIPSVDLSEEAWIERELESGIVFKKVDHVVASYDLSDEGWIERELESGIVIGQKNDQPVSLDGLTEDDWIERELESGIIVEPGPAGKKLKSKLLSEGHEIMNSRWEINGKSMQNQVT
What are the official names of this protein?
Cyclin-T1-2, CycT1;2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin T subfamily.
Protein: PAG15_CANLF
Sequence: MGLRRGPCPAALLPGGFLFLLLLADPALLAGRRPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKRTESYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVDWGYIRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKNKYIQAFVALGAPWGGVAKTLRVLASGDNNRIPVIRPLKIREQQRSAVSTSWLLPYNYTWSPEKIFVHTPTANYTLRDYHQFFQDIGFKDGWLMRQDTEGLVEAMVPPGVPLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLQSALQCQAWRGHQEHQVSLQALPGSEHIEMLANATTLAYLKRVLLGP
What is the function of this protein?
Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796).  Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796).  Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines.  Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity).  Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity).  Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress.  Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity).  At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
What are the official names of this protein?
Phospholipase A2 group XV, 1-O-acylceramide synthase, ACS, LCAT-like lysophospholipase, LLPL, Lysophospholipase 3, Lysosomal phospholipase A and acyltransferase, Lysosomal phospholipase A2, LPLA2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Membrane; Peripheral membrane protein.
Protein: FLOA_THEPX
Sequence: MTEFIFLLVVIGLIFVFLSVILSFIPLGLWISALAAGVKIGIFTLVGMRLRRVPPDKIVKPLIKAIKAGQDVEINKLEAHYLAGGNVDKVIDALIAAQRANISLEFERAAAIDLAGRDVLHAVQMSVNPKVIETPVVAAVAKDGIEVKVKARVTVRANIDRLVGGAGEETIIARVGEGIVTTVGSSNSHKEVLENPDSISRTVLNKGLDAGTAFEILSIDIADVDVGRNIGARLQIDQAEADKRIAQAKAEERRAMAVAREQEMKAMVQEMRAKVVEAEAEVPKAMAEALRTGKIGVMDYYNMRNVIADTMMRESFSKLGQERQQEEKE
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: HGT1_CANAL
Sequence: MSSKIERIFSGPALKINTYLDKLPKIYNVFFIASISTIAGMMFGFDISSMSAFIGAEHYMRYFNSPGSDIQGFITSSMALGSFFGSIASSFVSEPFGRRLSLLTCAFFWMVGAAIQSSVQNRAQLIIGRIISGIGVGFGSAVAPVYGAELAPRKIRGLIGGMFQFFVTLGIMIMFYLSFGLGHINGVASFRIAWGLQIVPGLCLFLGCFFIPESPRWLAKQGQWEAAEEIVAKIQAHGDRENPDVLIEISEIKDQLLLEESSKQIGYATLFTKKYIQRTFTAIFAQIWQQLTGMNVMMYYIVYIFQMAGYSGNSNLVASSIQYVINTCVTVPALYFIDKVGRRPLLIGGATMMMAFQFGLAGILGQYSIPWPDSGNDSVNIRIPEDNKSASKGAIACCYLFVASFAFTWGVGIWVYCAEIWGDNRVAQRGNAISTSANWILNFAIAMYTPTGFKNISWKTYIIYGVFCFAMATHVYFGFPETKGKRLEEIGQMWEERVPAWRSRSWQPTVPIASDAELARKMEVEHEEDKLMNEDSNSESRENQA
What is the function of this protein?
High-affinity glucose transporter (PubMed:10612724, PubMed:12187386).  Acts as a multifunctional complement-evasion molecule that causes down-regulation of complement activation by acquisition of human complement factors FH and C4BP (PubMed:21844307).  Functions also as a human immunodeficiency virus (HIV) receptor via binding the viral gp160 protein (PubMed:21844307).  Modulates hyphae formation (PubMed:21844307).
What are the official names of this protein?
High-affinity glucose transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CB076_PONAB
Sequence: MAPEEVTITVRLIRSFEHRNFKPVVYHGVNLDQTVKEFIIFLKQDVPLRTSLPPPFRNYKYDTLKIIHQAHKSKTNELVLSLEDDDRLLLKEDSTLKAAGIASETEIAFFCEEDYKNYKANPISSW
What are the official names of this protein?
UPF0538 protein C2orf76 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0538 family.