PharMolix/UniProtQA huggingface dataset:
Protein: RL5_MACFA
Sequence: MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHKLPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs.  It also couples ribosome biogenesis to p53/TP53 activation.  As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.
Protein: ACOX_CANGA
Sequence: MTKLSTVDPNASVLNPQRFIQRERENCSIDIDQVNTFLESDPRSRDLTHLIVDQLVNDPIIKADSATYDQTKLTQREVTVKKIARMALYMEQDIKTVRKHFRDTDLLKSLQDFGDTTTPPLTNKDLAIFDKRLSLVANMDPQLSTRIGVHLGLFGNCIKGNGTDEQIKYWLQTRGAILIKGIYGCFAMTELGHGSNVAQLQTTATYDQESDTFIINTPDLAATKWWIGGAAHSATHTACYARLLVNGKDYGVKTFVVPLRDPSSLQLMPGIAIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVHRNPGATPTVEVDPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIATRYAVGRQQFADKPGQPEKQLIDYPLHQYRVLPQIVIPYIISPAAFSLLNFYYSTLDELYAASSKNDKRALVVVSQKLKNLFIDSASLKATNTWLVAQLIDELRQTCGGHGYSGYNAFGKGYNDWVVQCTWEGDNNILSLTSAKSILKKFVDSATKGKYNKELDKRSFRYLDPQFIRKVFTSSSENKLDDLYDYTNIWAVALLKLLRHIAKQVDSTKDLDGASKLLVLVSKFHALYVMLNTYYEKLNSPTDSYVTCPKTKEQLWNVYKLFSLYFIDKHAGEFQQFKILSPDQISQVVQPRLLKLLPEIRKECISLTDSFKWPDGMLNAPIGYYDGDIYHNYFNEVVKNNPVEKDGAGIPPYHELLANMLTRGDEFARLGGANNAEILSKLTK
What are the official names of this protein?
Acyl-coenzyme A oxidase, Acyl-CoA oxidase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: SKI2_ARATH
Sequence: MNKVEAGNELGFRVGFSGHGGHLRVEPFYTAERDDALNSLPDFVSPPAFAKETKESIKKHIEEKYLIPRLEPDQFSAEKAENQWDFDWFSRVKMPLQPSLPRSVVVPTWELPFRRQKEDTENGAWEPKSVEVDLSEQMYGDQDSGFFPRMVGPPKDFLRGSVNNRPFRPGGLEDSQSSERVLPEGVSSGQWVQELLNGGPAQTVPPSFKQSLDLGDLMPYPQTWSVYEDHSSHGNASDENSSKLSIQFDDLFKKAWEEDTFSELEGDDHTAGSESPKAEAEPDAKASISNEVSKGLETDVTVLDEILSSAKTAIMSEEAVTGSSDKQLRKEGWATKGDSQDIADRFYELVPDMAIEFPFELDNFQKEAICCLEKGESVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGLLTGDVSIRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINFVLLSATVPNTFEFADWIGRTKQKEIRVTGTTKRPVPLEHCLFYSGELYKVCENEVFLSKGIKDAKDSQKKKNSNAVSVAPKQQMGSSAHQDGSKSQKHEAHSRGKQNKHSSVKDVGKSSYSGNSQNNGAFRRSAASNWLLLINKLSKMSLLPVVVFCFSKNYCDRCADALTGTDLTSSSEKSEIRVFCDKAFSRLKGSDRNLPQVLRLQSLLHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDALRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKTGTVVVMCRDEVPDESDLRRVIVGSATRLESQFRLTYIMILHLLRVEELKVEDMLKRSFAEFHAQKKLPEKQQLLMIKRSLPTKHIECIKGEPAIEDYYDMYMEANEYNNKMSEAVMQSPYAQSFLVQGRVVVMKSGMGIDNLLGIVLKGPSNTNRQYVVLVIKSEIPPPEKNMVSIGKKSSDPSQGYFIAPKSKRGFEEEFYTKPSSRKGPVVIKIELPYHGVAAGVGYEVKGFDNKEFLCICDSKIKIDQVRLLEDGNKAAFSQTVQQLLDLKSDGNKFPPALDPVKDLKLKDAELVETYYKWTNLLQKMSMNKCHGCVKLEEHMKLAREIKKHKTDLKDLEFQMSDEALLQMPAFQGRIDVLKNIGCIDDDLVVQIKGRVACEMNSGEELICTVCLFENQFEELEPEEAVAIMSAFVFQQKNTSAPTLTPKLAKAKQRLYDTAIRLGELQAQYNLQIDPEEYAQENLKFGLVEVVYEWAKGTPFAEICELTDVPEGLIVRTIVRLDETCREFKNAAAIMGNSALHKKMDAASNAIKRDIVFAASLYVTGV
What is the function of this protein?
Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:22511887).  Involved in the regulation of potassium deprivation stress response (PubMed:21535471).
What are the official names of this protein?
DExH-box ATP-dependent RNA helicase DExH11, AtHELPS, Protein SKI2 homolog, AtSKI2.
What is the protein family that this protein belongs to?
Belongs to the DExH box helicase family. SKI2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_SALTY
Sequence: MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPDLYEGDGELRVRVSFDKDKRTLTIADNGVGMNRDEVIDHLGTIAKSGTKSFLESMGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGDKPENGVFWESAGEGEYTVADITKNDRGTEITLHLREGEDEFLDDWRVRSIISKYSDHIALPVEIEKREEKDGETVISWEKINKAQALWTRNKSEIKDDEYNEFYKHIAHDFTDPLTWSHNRVEGKQEYTSLLYIPSQAPWDLWNRDHKHGLKLYVQRVFIMDDAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSTVTRNLRSALTKRVLQMLEKLAKDDAEKYQTFWKQFGLVLKEGPAEDHANQEAIAKLLRFASTHTDSSAQTVSLEDYVSRMKEGQEKIYYITADSYAAAKNSPHLELLRKKGIEVLLLSDRIDEWMMNYLTEFDGKAFQSVAKADESIEKLADEVDENAKEAEKALEPFVERVKTLLGDRVKDVRLTHRLTDTPAIVTTDADEMSTQMAKLFAAAGQSVPEVKYIFELNPDHVLVKRTADTKDEAQFKEWVELLLDQALFAERGTLEDPNQFIRRMNQLLVS
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_NEPOL
Sequence: MPVGVPKVPYRLPGESAPQWVDLYNRLYRQRLLFMGQELGDELSNQLCGIMIYLFAEDPSIPLFMYINSPGGSVTSGLGVFDIATVMMQDVTTICVGIAASMASLVLSGGSTGQRLALPHARMMIHQPEGGSRGQASDVMYESSEVERLRDIVVDCYVERTHQSRETIIIDLNRDLFMSPRQARSYGLIDAVALPAVKEEYTGFSMFS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: LACS6_ARATH
Sequence: MDSSSSSSSAAARRRINAIHSHLVTSSRSSPLLRSNPTAGEFCLDNGYSVVLPEKLNTGSWNVYRSAKSPFKLVSRFPDHPDIATLHDNFEHAVHDFRDYKYLGTRVRVDGTVGDYKWMTYGEAGTARTALGSGLVHHGIPMGSSVGIYFINRPEWLIVDHACSSYSYVSVPLYDTLGPDAVKFIVNHATVQAIFCVAETLNSLLSCLSEMPSVRLVVVVGGLIESLPSLPSSSGVKVVSYSVLLNQGRSNPQRFFPPKPDDVATICYTSGTTGTPKGVVLTHANLIANVAGSSFSVKFFSSDVYISYLPLAHIYERANQILTVYFGVAVGFYQGDNMKLLDDLAALRPTVFSSVPRLYNRIYAGIINAVKTSGGLKERLFNAAYNAKKQALLNGKSASPIWDRLVFNKIKDRLGGRVRFMTSGASPLSPEVMEFLKVCFGGRVTEGYGMTETSCVISGMDEGDNLTGHVGSPNPACEVKLVDVPEMNYTSADQPHPRGEICVRGPIIFTGYYKDEIQTKEVIDEDGWLHTGDIGLWLPGGRLKIIDRKKNIFKLAQGEYIAPEKIENVYAKCKFVGQCFIYGDSFNSSLVAVVSVDPDVLKSWAASEGIKGGDLRELCNNPRVKAAVLSDMDTVGREAQLRGFEFAKAVTLVLEPFTLENGLLTPTFKIKRPQAKEYFAEAITNMYKELGASDPSANRGL
What is the function of this protein?
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (Probable).  Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate as substrates (PubMed:12177484, PubMed:12366803).  Can use myristate and linolenate as substrates (PubMed:12366803).  May play a regulatory role both in fatty acid import into glyoxysomes and in fatty acid beta-oxidation (PubMed:12481085).  Functions redundantly with LACS7 in lipid mobilization for beta-oxidation during seed germination, which is essential for postgerminative growth and seedling establishment (PubMed:14742880, PubMed:16844736).
What are the official names of this protein?
Long chain acyl-CoA synthetase 6, peroxisomal, AtLACS6.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome. Glyoxysome membrane; Peripheral membrane protein.
Protein: RL9_DEHMB
Sequence: MKVVFLKDVPGRGKTGDIKEVNDGYARNYLIPNKLAMPASAAVKSEIAAKQAAEERRKAKAEAEMVELAKNLDGAKVNLKAKTGAKDKLYGQITTTVIAAEIEKQTGKTIDKRKLELAEPIRQLGNYEVVIRFNKDLSSKINLAVTAEENT
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: MCM10_SCHPO
Sequence: MHDPFIAEENDLDLEEKRLQRQLNEIQEKKRLRSAQKEASSENAEVIQVPRSPPQQVRVLTVSSPSKLKSPKRLILGIDKGKTGKDVSLGKGPRGPLPKPFHERLAEARNQERKRSDKLKTMKKNRKQSFQRKRNILEDGKSEEEKFPMKCDEIDPYSRQAIVIRYISDEVAKENIGGNQVYLIHQLLKLVRAPKFEAPEVDNYVVMGIVASNSGTRETVNGNKYCMLTLTDLKWQLECFLFGKAFERYWKIQSGTVIALLNPEVLKPKNPDIGRFSLKLDSEYDVLLEIGRSKHLGYCSSRRKSGELCKHWLDKRAGDVCEYHVDLAVQRSMSTRTEFASSMATMHEPRARREKRFRGQGFQGYFAGEKYSAIPNAVAGLYDAEDAVQTERERKERYKKQRAQAEREREILVRLSKRCCASSSSSSNSNNLSTGMSMRTLGHQYLNLQGSGVKNLHDKGNPTALSKDSEIDSSTKKPSVLASFNASIMNPKSSLPSFSNSAILGTNDAASGTPVPQDTTSTKVSPAVVFTSSPRIFSPQSLRKIGFDPTHSADASTTHSTATGLSRSGSLKNIKFRYEFTESDDEDDLEIVP
What is the function of this protein?
Required for DNA synthesis.  Required for entry into or completion of S phase.  Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation.  May play a role as key coordinator in assembling the replication fork.  Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41.  Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex.  May recruit the DNA polymerase alpha:primase complex to replication origins and is required to maintain it on chromatin independently of sna41.  May have primase activity.  Binds to single-stranded DNA.
What are the official names of this protein?
DNA replication licensing factor mcm10, Cdc23 protein, Minichromosome maintenance protein 10.
What is the protein family that this protein belongs to?
Belongs to the MCM10 family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: CLPX1_METCA
Sequence: MNEDRKNRESGKLLYCSFCGKSQHEVRKLIAGPAVFVCDECVELCNDIIREDLQGSEAGGVEGLPKPKEMKAILDQYVIGQDKAKRILSVAVYNHYKRLKARTFRNDVELAKSNVLLIGPTGSGKTLLAETLARVLDVPFTIADATTLTEAGYVGEDVENIIQKLLLACDYDVEKAEQGIVYIDEIDKISRKADSPSITRDVSGEGVQQALLKLMEGTVASVPPQGGRKHPQQEFLQVNTANILFICGGAFAGLDKTIRSRSERSGIGFSAEVKSKEENTNVGEILAGVEAEDLIRYGLIPEFIGRLPVVATLEELDEAALVRILIEPKNALVKQYARLFEMEGCELEILPEALGAIARRAMERKTGARGLRTIIEHALLDTMYELPSAEDVGKVVVDAKVIRGETEPHRVYRSVERQRVSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX 1.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RS10_STRT1
Sequence: MANKKIRIRLKAYEHRTLDTAAGKIVENATRTGATVAGPVPLSTERSLYTIIRATHKYKDSREQFEMRTHKRLIDIINPTQKTVDALMKLDLPSGVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: Y778_STAAN
Sequence: MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYVEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
What are the official names of this protein?
UPF0051 protein SA0778.
What is the protein family that this protein belongs to?
Belongs to the UPF0051 (ycf24) family.
Protein: ZNT4_BOVIN
Sequence: MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEVGDEGLSRFNKLRVVVADDGSEAPERPANGAHSALQADDDSLLDQDLPLTNSQLSLKADPCDNCSKQRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMKYEINGDIMLITAAIGVAVNVIMGFLLNQSGHHHAHSHSLPSNSPTTGPRCGHNQGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYRIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVHSVEDLNIWSLTSGKPTAIVHIQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVNRTCANCQSSSS
What is the function of this protein?
Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (By similarity).  Controls zinc deposition in milk (By similarity).
What are the official names of this protein?
Probable proton-coupled zinc antiporter SLC30A4, Solute carrier family 30 member 4, Zinc transporter 4, ZnT-4.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Note=Enriched in vesicles within the basal region of epithelial cells.
Protein: EFTU_STRS2
Sequence: MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSVNQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDLLSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPVEDVFSITGRGTVASGRIDRGTVRVNDEIEIVGLQEEKSKAVVTGVEMFRKQLDEGLAGDNVGVLLRGVQRDEIERGQVISKPGSINPHTKFKGEVYILTKEEGGRHTPFFDNYRPQFYFRTTDVTGSIKLPEGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGMVTEIEA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQA4_CAEEL
Sequence: MTKKAKRNIVHKRFDSIVKGSQDTKKYRGLELTNGLRVLLVSDSKTRVSAVALDVKVGHLMDPWELPGLAHFCEHMLFLGTAKYPSEREYFKYLAANNGDSNAYTDTDHTNYSFEVRSEKLYGALDRFAQFFLDPQFTESATEREVCAVNCEYLDKVNEDFWRCLQVERSLSKPGHDYSKFAIGNKKTLLEDPRTKGIEPRDVLLDFYKNWYSSDIMTCCIVGKESLDVLESYLGSFKFDAIKNTRKERKIWKDSPFGPDQLAKRIEIVPIQNTGQVSIKFPFPDLNGEFLSQPGDYIAHLIGHEGPGSLLSELKRLGWVISLEADNHTIASGFGVFSVTMDLSTEGLEHVDDVIQLVFNFIGFLKSSGPQKWIHDELAELNAVDFRFDDVKHTMEKASILAECLHPKIRKNFETALKTSHHAFNLPEKNEYIPSKFDQKPREPVKSGYPRLISEDEWIQVWFKQDNEYNSPKQGIMFALTTPLVAKKSKNVVAFKSLDTIIEETYNARLAGLECQFESSSSGVQIRVFGYDEKQSLFAKHLVNRMANFQVNRLCFDISFESLKRTLTNHAFSQPHDLSAHFIDLLVVDNIWSKEQLLAVCDSVTLEDVHGFAIKMLQAFHMELFVHGNSTEKDTLQLSKELSDILKSVAPNSRPLKRDEHNPHRELQLINGHEHVYRHFQKTHDVGCVEVAFQIGVQSTYNNSVNKLLNELIKNPAYTILRTNEALGYNVSTESRLNDGNVYLHVIVQGPESADHVLERIEVFLESAREEIVAMPQEDFDYQVWAMFKENPPTLSQCFSMFWSEIHSRQYNFGRNKEVRGISKRITKEEVINFFDRKIRKGGAERRKLALGLWKK
What are the official names of this protein?
Putative zinc protease C28F5.4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
Protein: PNPT1_PONAB
Sequence: MAACRYCCSCLRLRPLSDGPFCLPGRDRALTQLLVRALWSSTGSRAVAVDLGNRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLSDIPWNGPVGAVRIGIIDGECVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKHTHKLAMERLYAVFTDYEHDKVSRDEAVNKIRLDTEEQLKEKFPQADPYEIIESFNVVAKEVFRNIILNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESNGSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRTSRKENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSALHEARDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIRHPTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSSNSQ
What is the function of this protein?
RNA-binding protein implicated in numerous RNA metabolic processes.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction.  Mitochondrial intermembrane factor with RNA-processing exoribonulease activity.  Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner.  Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity).  Required for correct processing and polyadenylation of mitochondrial mRNAs.  Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix.  Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels.  In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells.  Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially.  Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs.  Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA (By similarity).
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase 1, mitochondrial, Polynucleotide phosphorylase 1, PNPase 1.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion matrix. Mitochondrion intermembrane space; Peripheral membrane protein.
Protein: HTPG_ALBFT
Sequence: MTKQTLSFQAEVAQLLHLVTHSLYSNKEIFLRELISNASDACDKLRYEAINDSGLYEDAPTLEVRVSFDPAAKTLTISDNGIGMSAQEAIDHLGTIAKSGTKDFVSKLSGDQKADSQLIGQFGVGFYSGFIVADKITVESRRAGMKASEGVRWISGGAGDFEVETIERAARGTSVILHLRDDAMDYCSAWKLKSIINKYSDHISLPILMEKEEWKDGELINPSDEKGGRQPGGMVKTGEWETVNKGNAIWARAKKDITPEQYTEFYKQISHDFEAPLAYTHNRVEGSTEYTQLLYLPSKAPMDLFNREKSAGVKLYVKRVFIMDDAEALLPTYLRFVKGVVDSADLPLNVSRELLQESRDVKAIREGCTKRVLGMLEDLAKHDKLPAPSADGGTDTTAGVSDVLSEEDKANEGKYSKFYAEFGAVLKEGLGEDYANKDRLAKLLRFASSSTDTVSVSFADYKARMKEGQEAIYYITADTPAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLQEFDGTPLQSVAKGAVDLGKLQDEAEKKAAEEAAETFKPLLAKLKEALKDKAEDVRVTTRLVDSPACLVVQDHGMSTQLARMLKQAGQAAPDVKPVLEVNAEHPLVKKLDGSVHFNDLAHILFDQALLAEGGLPADPAAYVKRVNALLV
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_CUPNH
Sequence: MITPQEALTRCIEHREIFHDEMLHLMRQIMQGQISPVMAAAILTGLRVKKETIGEISAAAQVMREFANKVPVADRENFVDIVGTGGDGSHTFNISTASMFVAAAAGAKIAKHGNRGVSSKSGSADVLEALGVNIMLTPEQVGQCIEETGIGFMFAPTHHPAMKNVAPIRKEMGVRTIFNILGPLTNPADAPNILMGVFHPDLVGIQVRVMQRLGAKHAIVVYGKDGMDEVSLGAATLVGELKDGEVREYEIHPEDFGLQMISNRGLKVADATESKEMLLEALTNVPGTPREIVSLNAGTALYAANVADSVEDGIRRAREAIASGAAQEKLDQFVRATQQFK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TLE3_RAT
Sequence: MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
What is the function of this protein?
Transcriptional corepressor that binds to a number of transcription factors.  Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling.  The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
What are the official names of this protein?
Transducin-like enhancer protein 3, rTLE3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat Groucho/TLE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_CICAR
Sequence: DLKAGGKNKKTKRTSPKSNDIYLKLLVKLYRFLVRRTDSNFNAVILKRLFMSKVNRPPLSLSRLIKYMQGKEGKIGVVVGAVTDDIRVYDVPTIKVTALKFTETARARIQKAGGECLTFDQLALRLPLTDTVLLRGPKNAREAVKHFGPAPGVPHSHTKPYVRSKGRKFEKARGRRKSRGFRV
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
Protein: PSUT_ECOLI
Sequence: MDIMRSVVGMVVLLAIAFLLSVNKKSISLRTVGAALLLQIAIGGIMLYFPPGKWAVEQAALGVHKVMSYSDAGSAFIFGSLVGPKMDVLFDGAGFIFAFRVLPAIIFVTALISLLYYIGVMGLLIRILGSIFQKALNISKIESFVAVTTIFLGQNEIPAIVKPFIDRMNRNELFTAICSGMASIAGSMMIGYAGMGVPIDYLLAASLMAIPGGILFARILSPATEPSQVTFENLSFSETPPKSFIEAAASGAMTGLKIAAGVATVVMAFVAIIALINGIIGGIGGWFGFANASLESIFGYVLAPLAWIMGVDWSDANLAGSLIGQKLAINEFVAYLSFSPYLQTGGTLEVKTIAIISFALCGFANFGSIGVVVGAFSAISPKRAPEIAQLGLRALAAATLSNLMSATIAGFFIGLA
What is the function of this protein?
Could be involved in pseudouridine transport.
What are the official names of this protein?
Putative pseudouridine transporter.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOD_LEPIC
Sequence: MENLQSMPEVQKIISLGKANGEVSYDDINEILPDKILNSEKIDDFFTLLHEMGIEIVEEYTRNTLEPASTLVPKDDSKPARKKKESSASTSGSEDPIKLYLREIGKVSLISGETEVFLAKRIEKGEKIIEETILSSSILRANYIKLLPKIRSKKIKVYDLIRVDKMYALNAEEAHKLEELFFKNILVIQEQEKVLQEAVSKIRKYSETSKKYKEFKEKIDASTEIIHNAIRELGVSQKEIQKISQKIKSMVFRIKEIDRHFLKIKAQYGQDVRDIKAFNRFIEKNEKLDDIEVKMGVNIDEVREVIKDIRNNERKLRRMEQEAGSTVQEIKDWGEKIIKGEREISQAKKELVKANLRLVVSIAKRYANRGMHFFDLIQEGNIGLIKAVDKFEYKKGYKFSTYATWWIRQAITRAISDQARTIRVPVHMIEQVNKVIRETRLFIQEFGRDPNNEEIAERLGWPVQKVKMVKNVAREPISLEIPVGSEEDSELGDFIPDTEVETPVNAAASSILAEQIRQVLHTLPAREQKVIRMRFGLDDGYPQTLEEVGYQFKVTRERIRQIEAKALRRLRHPSRSKKLKDYIDG
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor RpoD, Sigma-70.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.