PharMolix/UniProtQA huggingface dataset:
Protein: MIAB_XYLFA
Sequence: MTGTSNIPTHGKEHKDAPALLPLPAPNPHHTHAAHPGNPSHDRPPSRGKLFIKTHGCQMNEYDSAKMADVLTTTEALELTDNPEEADIILINTCSIREKAQEKVFSQLGRWRALKTSGRDVIIGVGGCVASQEGEAIVKRAPYVDLVFGPQTLHRLPDMIRARREQNRPQVDIRFPEIEKFDHLPTPRAEGPSAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFEDVLTEIAHLATQGVREINLLGQNVNAYRGAMDPGPSNNTNPAPPPYADLGLLIRAIAQFESIGRIRFTTSHPLEFSDSLVEAYRDVPQLANHLHLPVQSGSDRILSAMKRGYTALEFKSKIRKLRAVRPDISISSDFIIGFPGESDTDFQKTMQLIEDIGFDQSFSFIYSRRPGTPASNLEDHTPDEIKRTRLEHLQKHINTYAADISKRMIGTVQTVLVEGPSKKNPNELTGKTENMRPVNFPGHPRLIGQFIDVHITEALSNSLRGRVHTN
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SALTI
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_KLEP7
Sequence: MSTYLIGDVHGCYDELIALLAQVEFDPRRDTLWLTGDLVARGPGSLEVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLKPLLEAPDADELLNWLRRQPLLQVDEEKKLVMAHAGITPQWDLETAQQCARDVEAVLSSDSYPFFLDAMYGDMPNHWSNELSGLARLRFISNAFTRMRYCFPNGQLDMYSKEAPEDAPAPLKPWFAIPGPVSNAYSIAFGHWASLEGRGTPEGIYALDTGCCWGGELTCLRWEDKQYFTQPSNRQKSLDEGEAVAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: FENR1_OCEIH
Sequence: MEVFDVTIVGGGPAGLYSAFYSGLREMKTKIIDYQAELGGKVHIYPEKVIWDIGGLTPMSGENVIKQMVEQAMTFDPTVVLNEKVESIDKNEMGLFQLHTASGEIHYSKTIIVAVGGGILHPKRLNLEGAEKYEVTNLNYKITSLQRYKDKRVIISGGGNSAVDWANELVDIAKSVYLTYRKDVLSGHEAQVTKLMKSSAECYFNCSITKLISENNQSIEHVELTNHESGDILALPIDEVIINHGYDRDIDLLDNSPSLGVEIKDGYFVAGSPNSESSVPGIYAAGDILHHEGKLHLIAGAFQDAANAVNQAKKYIDPMANNFAMVSSHNEMFKERNEKLKASAAASV
What are the official names of this protein?
Ferredoxin--NADP reductase 1, FNR 1, Fd-NADP(+) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: PANC_MYCBO
Sequence: MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALHEGHLALVRAAKRVPGSVVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEIAFTPTTAAMYPDGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQLVADFNLDVAVVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALTAAAHAATAGAQAALDAARAVLDAAPGVAVDYLELRDIGLGPMPLNGSGRLLVAARLGTTRLLDNIAIEIGTFAGTDRPDGYRAILESHWRN
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPH1_SOLLC
Sequence: AGDVIYIVR
What are the official names of this protein?
Purple acid phosphatase isozyme LeSAP1.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SCX5_CENNO
Sequence: MNSLLMITACLFLIGTVWAKEGYLVNKSTGCKYGCLLLGKNEGCDKECKAKNQGGSYGYCYAFGCWCEGLPESTPTYPLPNKSCSKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp. )), it provokes a reversible paralysis to insects (crickets (Achaeta spp. )), but is not toxic to mice.  At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes.
What are the official names of this protein?
Beta-toxin Cn5, CngtII.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AA3R_SHEEP
Sequence: MPVNSTAVSWTSVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLGVTIHFYSCLFMTCLMLIFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWNMKLSSADENLTFLPCRFRSVMRMDYMVYFSFFLWILVPLVVMCAIYFDIFYIIRNRLSQSFSGSRETGAFYGREFKTAKSLLLVLFLFALCWLPLSIINCILYFDGQVPQTVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVMCQPSKSMDPSTEQTSE
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGB_SHEON
Sequence: MTQAQTYFYDGSDVALLNGQYTDVFSLLGMHSINEGKALVVRCFLRNAQKVDVISLKDGRKVASLERVNEAGLFAGTLGRRIKPFLYALRVTYPLCELDIIDPYQFGSLLNREDLYLFGEGSSEQAYRFLGANWRQVDNVEGVHFCVWAPNAKRVSVVGDFNHWDDTRHVMRQHVANGLWEIFLPGVVEGSHYKFDLVYQNGERHAKSDPMATQMECAPHNASIVPKKQQHQWADTQWMDKRAATAWHRAPMSIYEVQLGSWRRKGEFGEQYFDYQDLIEQLIPYVKEQGFTHIELMPVSEYPFDGSWGYQPVGLYAPTYRFGDANGFKAFIDACHQAEIGVLLDWVAAHFPKDPHGLVRFDGTCLYEHEDPRKGTHPDWDTLIYNYGRGEVRSFLLSNACYWLREFHLDGLRLDAVSSMLYLDYSREPGQWLPNAYGGRENLEAIDFLQMLNQRLYQAIPGICMIAEESTAFAGVTKPTDSSGLGFGFKWNMGWMNDSLSYLGRDPIYRQYHHNQLTFSLMYAYSEQFMLSISHDEVVHGKGSLLHKIPGDDWQKFATLRAYYGFMWGHPGKKLLFMGSEFAQRDEWDHDHSLDWHLLAFEPHQGVQRWLRDLNQLYRQFPALSVLDYEPQGFRWLDCDNGRDSIFSFVRYGEGNDVPLVFVVNMTPTVHQGFRIGLPQGGDFCEYLNSDSYLYGGSNQGNGGKIIAQALPWQGMASSALITVPPLGCLILGPATENILRESAL
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: MASZ_PSEF5
Sequence: MTEHVQVGGLQVARVLFDFVNNEAIPGTGLTADSFWAGADKVIHDLAPKNKALLAKRDDFQARIDAWHQSRAGQAHDAVAYKAFLQDIGYLLPEAADFQATTQNVDEEIAHMAGPQLVVPVMNARFALNASNARWGSLYDALYGTDAISEADGAEKGKGYNKVRGDKVIAFARAFLDESAPLTAGSHVDSVSYKIVGGKLVVGLKGGSNSGLRNDAQLIGYQGDAAAPTAILLKHNGLHFEIQIDATSPVGQTDAAGVKDLLMEAALTTIMDCEDSVAAVDADDKVVIYRNWLGLMKGDLAEEVSKGGKSFTRTMNADREYTGVNGEPVKLHGRSLLFVRNVGHLMTIDAILDKDGNEVPEGILDGLVTSLASIHNLNGNTSRKNSRTGSMYIVKPKMHGPEEAAFTNELFGRIEEVLNLPRNTLKVGIMDEERRTTVNLKACIKAASERVVFINTGFLDRTGDEIHTSMEAGAMVRKADMKAEKWIGAYENWNVDIGLSTGLQGRAQIGKGMWAMPDLMAAMLEQKIAHPLAGANTAWVPSPTAAALHALHYHKVDVFARQAELAKRARASVDDILTIPLAVNPSWTPEQIKNELDNNAQGILGYVVRWIDQGVGCSKVPDINDVGLMEDRATLRISSQHIANWLRHGVVTQEQVLESLKRMAPVVDRQNASDPLYRPLAPDFDSNIAFQAALELVIEGTKQPNGYTEPVLHRRRREFKAKNGL
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LE05_BIOGL
Sequence: LEIADLAQYVVDLTAR
What is the function of this protein?
Binds and precipitates antigens of the parasite Echinostoma paraensei.
What are the official names of this protein?
Hemolymph 65 kDa lectin BG05.
What are the subcellular locations of this protein?
Secreted.
Protein: CPEB4_HUMAN
Sequence: MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN
What is the function of this protein?
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967).  RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967).  Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity).  Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195).  Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752).  Stimulates proliferation of melanocytes (PubMed:27857118).  In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein 4, CPE-BP4, CPE-binding protein 4, hCPEB-4.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.
Protein: ACUB_ASPA1
Sequence: MKIDVHHHFYPQAFREALEAAGGDPSGWYIPPWTLELDQEINATLNVTTTILSVTAPGPVIAKDPAAAASLARECNRSAAAIRDAAPAQYGFFASVPSLFDTALALEEIRYALDELHADGVTLFTRYGQGANYLGHEAFAPIWAELSRRQAVVFIHPTHPQDTALINRALPQPMFDYPHETGRTAMDLLTSGRLRQHRGCRVILSHAGGTLPYLIHRAATMLPCMPPDRNIGLSRDEILDTAREVFYFDTAISANEVTLSALARFAKPGHILFGSDFPNAPRDAIVRFTRFVEEEAAALPDGVTVEALKENALQLFPRLKRAEANGVPKI
What is the function of this protein?
6-methylsalicylic acid decarboxylase; part of the gene cluster that mediates the biosynthesis of aculins (PubMed:26374386).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) acuA via condensation of acetate and malonate units (PubMed:26374386).  The 6-methylsalicylic acid decarboxylase acuB then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol) (Probable).  These first reactions occur in the cytosol (By similarity).  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase acuC converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase acuD (Probable).  Gentisyl alcohol is further oxidized by the oxidoreductase acuE that probably catalyzes hydroxylation of the aromatic ring (Probable).  The aromatic system might then be opened by oxidation through a Baeyer-Villiger type of oxidation, which could be catalyzed by acuF, with the carboxylic acid at C-1 subsequently reduced to an aldehyde by acuG (Probable).  Subsequently, a hemiacetal is formed, before the dehydrogenase acuH would reduce the double bond between C-4 and C-6 (Probable).  Finally, keto-enol tautomerism results in formation of aculinic acid, which exists as two diastereomers (both R/S configurations at C-1) by non-enzymatic hemiacetal formation (Probable).  The carboxypeptidase acuI could be involved in the linking of aculinic acid to an aculene A moiety produced by the aculene biosynthesis cluster and which leads to the production of aculin A (Probable).  AcuI may also be involved in the attachment of proline to aculinic acid to form epi-aculins A and B (Probable).
What are the official names of this protein?
6-methylsalicylic acid decarboxylase acuB, Aculin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: DNLJ_RHOBA
Sequence: MPQDRFVASDSIASRVQQLVDEINRHNRLYYDDAAPEITDLQYDQLLAELTQLENDHPDLRRPDSPTQLVGGDVVDQLVQVPHRVPMLSIDNTYSREELAAAMERIEKSLEGESVAWTMEYKIDGVAGSIRYENGELTLALTRGNGQVGDDITHNVRTIRELPRSIADAALAHPEVAGGNVPEVLEVRGELYMTDADLADLNVRQTDAGHEPFKNTRNVTAGTIRLLDPKIAASRNIRFFCHGSGELVGVRASDHMTFLQHVQALGIPIAPDVVRFENKEDALQAIAKLELEMPDLPFEIDGIVFKVDSFEQREKLGVRSKSPRWVIAYKFERYEAITTLEAIDVQVGKTGTITPVAYLTPVDIADTTVSRASLHNADEIERLDVRVGDTVVVEKAGKIIPKVVRVEKHARTKPLPKFEFPTHCPQCDEVLTRDEGGVYIRCTNPACPAQLRQRLVYFGSRTGMDIDGLGEEVVDLLLQKELVENYADLYRLNVDELAELTWPRLRKGKGDEMIEVQFGRKNAESLVAGINESRTRGLARVLSSISIRHIGPRVAKLITAKFWNLDLLRSAKAEDLAAIHEIGDRIAESLVKFIHSESGSQTLSDLDAVGVTMSETEPVATPDEEANLPLAGKNIVATGTLQHYTRDEIKARIEELGGRAASSVSKKTDFLIAGEKAGSKLTKAESLGVEVLSEDDFRLRYETEAT
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NDHH_WHEAT
Sequence: MSLPLTRKDLMIVNMGPQHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEFLENIQIPQRASYIRVIMLELSRIASHLLWLGPFMADLGAQTPFFYIFRERELIYDLFEAATGMRMMHNYFRIGGVAADLPYGWIEKCLDFCDYFLRGVVEYQQLITQNPIFLERVEGVGFISGEEAVNWGLSGPMLRASGIQWDLRKVDPYESYNQFDWKVQWQKEGDSLARYLVRVGEMRESIKIIQQAVEKIPGGPYENLEVRRFKKEKNSEWNDFEYKFLGKKPSPNFELSRQELYVRVEAPKGELGIYLVGDDSLFPWRWKIRPPGFINLQILPQLVKKMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RN212_HUMAN
Sequence: MANWVFCNRCFQPPHRTSCFSLTNCGHVYCDACLGKGKKNECLICKAPCRTVLLSKHTDADIQAFFMSIDSLCKKYSRETSQILEFQEKHRKRLLAFYREKISRLEESLRKSVLQIEQLQSMRSSQQTAFSTIKSSVSTKPHGCLLPPHSSAPDRLESMEVDLSPSPIRKSEIAAGPARISMISPPQDGRMGPHLTASFCFIPWLTLSKPPVPGECVISRGSPCFCIDVCPHWLLLLAFSSGRHGELTNSKTLPIYAEVQRAVLFPFQQAEGTLDTFRTPAVSVVFPLCQFERKKSF
What is the function of this protein?
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes.  Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11.  May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites.  Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).
What are the official names of this protein?
Probable E3 SUMO-protein ligase RNF212, Probable E3 SUMO-protein transferase RNF212, RING finger protein 212.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).
Protein: Y1829_DICDI
Sequence: MPYYLSILNSIALFLIFPINIFLFIFHHNSWIQTFFLLFLIVFSIFLFSINIFELYLPKKRIITFIEELNNEYSNRLISFHINQEEDIVLLYPLPDHFYKNVPFPFFQIHQPIQQDQNQQLQEPLPGKQYQEQQKHETYTSIDFQPIIETNQYSEPLLSEIEEYTPIDLKEQI
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0281321.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THMS2_MOUSE
Sequence: MEPVPLQDFVSGLDPTSLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHVQLQKVVCEYPETGQTLELNPNFTGLFSPLTSLRSYRTLEDLVSAMPQNSTRWPIYFKSTQRIVTKASVVPEDQPLRLEAVEIHHGIRYARCVQVSKTKELLHLPLSQKGPFWRCKPSAPQTLHQILQDPALKDLTLSCPSLPWNSVILKPQYMLQAIMHMRSSIVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAGGGPFPLTTEILEVPEGPPVFLSPWVSFLRKGQRLCIYGPASPSWRVVASSKSRKVPRYFMLSGAYQGKLKRRPREFSTAYDLLGALQPGRPLRVVATKDCDGNEEENPDFSFLAVGDRLEVLRSGQVCGTKGQDIDVLVCQRLSEQSGEEEEDLEEIEDEAEDKEQILLPLYLSGSFVEEVNDSRRYNLVDLTAQYSLPCEVKVVTKDTRHPTDPLASFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEAEGQPAQVARPLSIAPVEELSEAFYYSLRKLPASESQAPPPRPPKSQGINKKQQNIQSCKESSVKPQVVEPQKSCPQPQLKAKTLEALPKNKSNVYSKISVHKKDRKPNPQTQNSVLSMKPKTSSSLGKHSTMESHLLPDPDMDDHDYEEI
What is the function of this protein?
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716).  Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (PubMed:27992403).
What are the official names of this protein?
Protein THEMIS2, Induced by contact to basement membrane 1 protein, Protein ICB-1, Thymocyte-expressed molecule involved in selection protein 2.
What is the protein family that this protein belongs to?
Belongs to the themis family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RSBV_STAAM
Sequence: MNLNIETTTQDKFYEVKVGGELDVYTVPELEEVLTPMRQDGTRDIYVNLENVSYMDSTGLGLFVGTLKALNQNDKELYILGVSDRIGRLFEITGLKDLMHVNEGTEVE
What is the function of this protein?
Positive regulator of sigma-B activity.  Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B.  When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
What are the official names of this protein?
Anti-sigma-B factor antagonist, Anti-anti-sigma-B factor.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor antagonist family.
Protein: RS20_TRIL1
Sequence: MAHHKSAIKRIKQNEKRNARNRHQKSTLKTYIKRVREAVESKDKEAAVAALQVAIPVIDKTATKGVIHKANASRSVSRLTKLVNTLG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SP5_MOUSE
Sequence: MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAAPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPAPAPDDLPWWSIPQSGAGPGSSGVPGTSLSSACAGPPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKRENPRDL
What is the function of this protein?
Binds to GC boxes promoters elements.  Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo.
What are the official names of this protein?
Transcription factor Sp5.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 5HT1B_MOUSE
Sequence: MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior.  Besides, plays a role in vasoconstriction of cerebral arteries.
What are the official names of this protein?
5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, Serotonin receptor 1B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.