PharMolix/UniProtQA huggingface dataset:
Protein: FES1_NEUCR
Sequence: MDKNLNQLLKWSIEAQTAANAGQSYHSNGAPTPNNNSGPATGTGAVATSPAPQVTGSGPRPVDPEVLASLFGGPSEAELMKAAMEVITDPSPETTRENKLIAFDNFEQLIENLDNANLLEELSLWSPLISLLDHEDEDMRYHAAWCLGTAVQNNQKTQERLLAMGGVPKLVDLAMKEGESEKVRRKATYALSSAVRNYQPAMDVAADEMHKRGHEVLVNNGTKVDAADMDKVDEVIDVLRNKAKSA
What is the function of this protein?
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP.  Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
What are the official names of this protein?
Hsp70 nucleotide exchange factor fes-1.
What is the protein family that this protein belongs to?
Belongs to the FES1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_NITHX
Sequence: MTSSPIRILGIDPGLRRTGWGVLDIEGNRLMFVGCGSVETREQMALASRLLAIHEGLGRVLDEFRPAEAAIEQTFVNKDGVATLKLGQARGVAMLAPAMFGIVVAEYAPNQVKKTVVGAGHADKTQIQAMLKILLPKADPKSADAADALAIAITHAHHRGAAALRMKVAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CGS1_ARATH
Sequence: MAVSSFQCPTIFSSSSISGFQCRSDPDLVGSPVGGSSRRRVHASAGISSSFTGDAGLSSRILRFPPNFVRQLSIKARRNCSNIGVAQIVAAKWSNNPSSALPSAAAAAATSSASAVSSAASAAAASSAAAAPVAAAPPVVLKSVDEEVVVAEEGIREKIGSVQLTDSKHSFLSSDGSLTVHAGERLGRGIVTDAITTPVVNTSAYFFKKTAELIDFKEKRSVSFEYGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTDCYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIELVSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLVSEIRNLHHVLGGTLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPGLPSHPEHELAKRQMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQPAIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI
What is the function of this protein?
Catalyzes the first committed step of methionine (Met) biosynthesis.  Catalyzes the formation of L-cystathionine from homoserine esters and L-cysteine, via a gamma-replacement reaction.  Substrate preference for cystathionine synthesis is O-phospho-L-homoserine (OPH) > O(4)-succinyl-L-homoserine (OSH) >> O-acetyl-L-homoserine (OAH).  Is able, at extremely low rate, to catalyze a gamma-elimination of OPH in the absence of cysteine to produce inorganic phosphate (Pi), 2-oxobutanoate and ammonia.
What are the official names of this protein?
Cystathionine gamma-synthase 1, chloroplastic, AtCGS1, METHIONINE OVERACCUMULATION 1, O-succinylhomoserine (thiol)-lyase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ILL3_ORYSJ
Sequence: MSTTAATTLGRELLEAARAPEFAGWLRGLRRRIHQHPELAFQEHRTSALVRAELDALGVAYVWPVAQTGVVATVVGAAGPGPVFGLRADMDALPIQEMVEWEFKSLEDGKMHACGHDVHVAMLLGAAKLLQSRRDHFNGKVKLVFQPAEEGYAGGYYVLEEGAVDDVQGIFGMHVDAGLPAGVVASRPGPFLAGSARFTATINGKGGHAAAPHHAVDPIVAVSSAVLSLQQIVARETDPLQGAVVSVTTIKGGEAFNVIPESVTLGGTLRSMTTDGMSYLMKRIREVIEGQAAVNRCTAAVDFMEDKLPPYPATVNDEEMYAHAKAVAESMLGEANVKLSPQGMGAEDFGFYAQRIPAAFFGIGVGNDGGGMAETTTKNQLHSPHFVVDEEALPVGAAFHAAVAIEYLNKNASGPSA
What is the function of this protein?
Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA).
What are the official names of this protein?
IAA-amino acid hydrolase ILR1-like 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: CYBR1_HUMAN
Sequence: MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGGTEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM
What is the function of this protein?
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000).  Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000).  It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337).  May also act as a ferrireductase in airway epithelial cells (Probable).  May also function as a cupric transmembrane reductase (By similarity).
What are the official names of this protein?
Plasma membrane ascorbate-dependent reductase CYBRD1, Cytochrome b reductase 1, Duodenal cytochrome b, Ferric-chelate reductase 3.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border of duodenal cells.
Protein: GDH_AGRFC
Sequence: MRLNNKVALITGAARGIGLGFAQAFAAEGAKVIIADIDIARATTSAAAIGPAAKAVKLDVTDLAQIDAVVKAVDEEFGGIDILVNNAAIFDMAPINGITEESYERVFDINLKGPMFMMKAVSNVMIARARGGKIINMASQAGRRGEALVTLYCASKAAIISATQSAALALVKHGINVNAIAPGVVDGEHWEVVDAHFAKWEGLKPGEKKAAVAKSVPIGRFATPDDIKGLAVFLASADSDYILAQTYNVDGGNWMS
What is the function of this protein?
Involved in galactitol catabolism.  Catalyzes the oxidation of galactitol to D-tagatose.  Can also catalyze the oxidation of D-sorbitol to D-fructose.
What are the official names of this protein?
Galactitol 2-dehydrogenase, GDH, Sorbitol dehydrogenase, SorbD.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ANTIH_BPP2
Sequence: MKKLSLSLMLNVSLALMLALSLIYPQSVAVNFVAAWAILATVICVVAGGVGVYATEYVLERYGRELPPESLAVKIVTSLFLQPVPWRRRAAALVVVVATFISLVAAGWIFTALIYLVVSLFFRLIRKACRQRLEGREPCQG
What is the function of this protein?
Involved in lysis inhibition.  Interacts with and inhibits the holin thereby delaying the host cell lysis timing.
What are the official names of this protein?
Putative antiholin, Protein lysA.
What are the subcellular locations of this protein?
Host cell inner membrane; Multi- pass membrane protein.
Protein: NEUL_RAT
Sequence: MITLCLSTLRGLHRAGGSRLQLTMTLGKELASPLQAMSSYTAAGRNVLRWDLSPEQIKTRTEQLIAQTKQVYDTVGTIALKEVTYENCLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEHIRNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREFILSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNGS
What is the function of this protein?
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (PubMed:7836437).  Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343).
What are the official names of this protein?
Neurolysin, mitochondrial, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Cytoplasm, cytosol.
Protein: CISY_BAREL
Sequence: YIDGDKGILLYRGYPIDQLAEKGDFLESCYLLLYGELPTQQEKNDFDRCIMQHTMVHEQFSRFFHGFRRDSHPMAVMVACLGAMSAFYHDSIDITDPHQRMIASVRLISKVPTLAAMAYKYSIGQAFVYPRNDLSYAANFLRMCFAVPCEEYKINPVLARAMDQIFILHADHEQNASTSTVRLAGSSGANPFACIAAGVACLWGPAHGGANEACLKMLQEIGSIKRIPEFIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQKTCHEVLKELNIQDDPLLDIAIELEKIALSDEYFIEKKLYPNVDFYSGITLKALGFPTE
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: AROQ_PHEZH
Sequence: MSKPIYVLSGPNLNLLGTREPEIYGHQTLDDVRRLCEARAKSLGREIVFRQSNHEGELIDWIQEAREKACALVINPAGYGHTSVAILDALKAVGLPVVECHLSNPAARETFRRKTYVSLAATGVVSGFGAASYELAVEAAAGLAR
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: YBEY_SHESM
Sequence: MSLDLALDVQYATASDYLPSEEQFALWVKTAIGNSMEQAELTIRIVDSRESQMLNSTYRGKDKPTNVLSFPFEAPPEIELPLLGDLVICATVVENEAREQDKTLEAHWAHMVVHGCLHLLGYDHIEDEEAEEMESLETQLIESLGFTDPYKEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI19_ASHGO
Sequence: MKQDKRKYSGFVQSVGITCVLILIILWTLLPYPLLDPEKRLAEPQTTTESISLFLDELVELFPQRYWIICIQCMILMDMLFVYIGLPIFNQSVLTVRLDDLRTITDSKASVVMCESHAEFLTSYAHTETSGVYDLPITEVSRLLYGKARHKSD
What is the function of this protein?
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.  Involved in cell wall biosynthesis (By similarity).
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19.
What is the protein family that this protein belongs to?
Belongs to the GPI19 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LEPA_BRUMB
Sequence: MSTPLDHIRNFSIVAHIDHGKSTLADRLIQLTGGLDTREMKDQVLDSMDIERERGITIKAQTVRLSYKAKNGEDYVLNLIDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYQAIDNNHEIVVVLNKIDLPAAEPERVKQQIEEVIGIDASDAVEISAKTGLGIEDVLEAIVNKLPAPKEGDRNAPLKAMLVDSWYDSYLGVIVLVRVIDGVLKKGQTIRMMGTGAKYPVERTGVFTPKMVQVDDLGPGELGFITASIKEVADTRVGDTITEDRRPTENMLSGFKPAQPVVFCGLFPVDAADFEDLRGAMGKLRLNDASFSFEMETSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLITTAPSVVYRLNMTDGTHKELHNPADMPDVVKIASIEEPWIKATIMTPDDYLGAIMKLCQERRGIQIDLTYVGPRAMITYDLPLNEVVFDFYDRLKSISKGYASFDYNLSDYREGDLVKMSILVNEEPVDALSMLVHRSAAEKRGRALCEKLKELIPQHMFKIPIQAAIGGRIVARETISALRKDVTAKCYGGDVTRKRKLLEKQKESKKRMRQFGKVEIPQEAFIQALKMGDD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RECA_LISMC
Sequence: MNDRQAALDQALKQIEKQFGKGSIMKLGEHSDQNISTISSGSLALDIALGVGGYPRGRIIEVYGPESSGKTTVALHAIAEVQAQGGTAAFIDAEHALDPAYAKNLGVNIDELLLSQPDTGEQALEIAEALVRSGAVDMLVIDSVAALVPRAEIEGEMGDAHVGLQARLMSQALRKLSGVINKSKTIAIFINQIREKVGVMFGNPEITPGGRALKFYSTVRLEVRRAEQLKQGTDVMGNKTKIKVVKNKVAPPFRIAEVDIMYGEGISREGELVDMAAEVDVINKSGSWYSYKEERIGQGRENAKQYLKEHTDIRDEISKRVREEYEIDGSNKEPLDEGEETLSLLDDE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_ECOBW
Sequence: MAQIFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFGADVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMPLEGVKALTDFMVEFERRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCL1_NEOFI
Sequence: MTEQISLVDVSSSVSLKGEDSSNVALLRDLFINDVAASDPAESSADVHKDEHSSDNSDNDNEAVPKPNDFSQRRRIQNAQFEALLSKRTDADSNEAIDRAPIALSDDELSIAHLVEKQDLGNGMLDPREYQIELFERAKTQNTIAVLDTGSGKTLIAVLLLRHTILNELDNRANGKPHRVSFFLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWDKRTWDEHLQRNMVIVCTAEILNQCLLNSYVKMDQINLLIFDEAHHAKKDHPYARIIRDSYFKAQPSQRPRVFGMTASPIDTKGDITEAATRLETLLDSRIATTSKITLLREVVSRPIEKVWAYNRLESPFATELYKLMDTRYGNIKVLEGVYRFAWHASSELGKWCSDRAWWHALADDVLPKLEGNISKLVESNTLNAEHGAVFKDIIRIREASETVKNYSFADPELPGELSPKVQLLRMELSKHFSDTTGTKCIVFTQKRYTAKILNELFTVLNIPHLRPGVLIGVRPGDIGGMNVTFRQQFLALVKFRTGEINCLFATSVAEEGLDIPDCNLVVRFDLYRTLIQYVQSRGRARHCTSTYAIMVEKDNAEHEGRLKEIREAEKIMQRFCETLPEDRILHGNDHDLDSLLQEEEGRRTFTVKSTGAKLTYHSAIAILARYASSLQYEKETVPQVTYVVGHVSNAYVCEVILPEKSPIRGLTGSPAIRKAVAKQSAAFDTCLLLRKHRLLDDYFNSIYHRRLPAMRNAKLAITCKRTNEYDMLLKPSIWAKQRTTPIDKLYGIHISLLPSKPLSRDHRPILLLTREKLPEFPAFSIYLDEDVETKVLSYPLKHGLQISVDELQSLTTFTLRIFRDIFHKVYEHEVQKMPYWLAPAKALDGPGSGTNPRDWTDWDTVSFVHNNDEIPFTRDLNPDSLVNRFIFDNWDGRFRYFTVAVADTLQPSDPPPPSVPRRRHMNNIMNYTLSLSKNSRARFFSGCDWNQPVLQAELVRLRRNLLDKMTTQEKEMQTECFICAEPLRISAIPTSIVSTCLAFPAIISRLDSYLIALEACDELELVIRPDFALEAFTKDSDNTEEHRGQQIHFQRGMGKNYERLEFLGDCFLKMATSIALYTQNPDDDEFDYHVNRMCLICNKNLFNTAIKKQIYRYIRSRGFSRHIWYPDGLTLLHGKDHSKKLLSEGKHALGEKTIADVCEALIGASLLSGGPENRFDMATKAVTALVDSPSHRVSCWKEYITLYTMPKYQTEKPRGSEDDLARHVEEELGYHFTYPRLLASAITHPSLPSTWGYRVPCYQRLEFLGDSLLDMVCVEDLFRRFPDRDPQWLTEHKMAMVSNKFLGALSVKLGFHRRIMAFSNPLQAQITHYVEEIESAQAESRGAVDYWVVAKDPPKCLPDMVEAYLGAIFVDSKFDFQVIEVFFERQIKPFFEDMSIYDTFANKHPTTFLHNKLTNEYGCTNYCLKAGELPTIDGAPAGVLAAVIVHGNVISEARSSSSRYAKVKASEKALAVLDGLLPFEFCQKYHCGCKETQNSSSAVEIGTAI
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense response against viral infection and transposons (By similarity).
What are the official names of this protein?
Dicer-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: COX2_LASSP
Sequence: MNTWLLSLQNSNSPTYDMMIFFHDFTMMILIFITLLILFIMFTMINNNLINRFLLQGHFIELIWTITPMIILILIAIPSFKILYLTDEMFNNKITIKSVGHQWYWSYEYSDFLNIEFDSFMIPSNQLNPNEFRLLDTDNRCILPFNYPIRILTTSMDVIHSWTVPSLGIKMDSTPGRLNQSLLYMYRPGLYFGQCSEICGTNHSFMPIVIESTNFSYFKNWLKSFL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISPT_AQUAE
Sequence: MSLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFSTENWNRPKEEVKALFELMENYIRSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSKDFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFSQFLDLSCSPDPDLLIRTAGEKRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: PRMA_CAMHC
Sequence: MKKNYYEMEVSSKNASELFKNFSFELGVEAIEEKENSFIIRDEEDLQNLEFAFIEFQKALQKKFNTKIDLQISKSIKENADWIEKYQKSVEPIEVGKFYVRPSWKESKKELIDIIIDPAIAFGSGHHESTNMCLKLIDKYAKDGATALDVGCGSGILSIALKKIGLKVAACDTDIQAVDASIKNAQKNGVKIDKIWNGSIADANLAIRNMDGEILSENLNENKNFNQSFNKEFDFVIANIITDVILILQNELKNSVKSGGILIISGILEKYKNKILNVFSDMNNLEILQNGEWVSFVFKKG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_BIFLO
Sequence: MTYKLVLLRHGQSAWNKTNQFTGWVDVPLTEQGEAEAKRGGELLKEKNVLPDIVFTSLLRRAINTANIALDAADRLWIPVQRDWRLNERHYGALQGKNKTEIREEYGDEKFMLWRRSYATPPPEIDPNDQYAQNNDPRYAGDPVPEAECLANVVERVKPYFESAIEPELKAGKTVLIAAHGNSLRAIVKMLDNLSEEEIAKVNIPTAIPLLYELDENFKPIKPRGEYLDPEAAAAGAAAVAAQGQK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: UPP_SHIFL
Sequence: MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: SAMP_PIG
Sequence: MERLLLWVSVLASLPEAFAHRDLTGKVFVFPRESATDHVKLITKLEKPLQNFTLCFRAYSDLSRGYSLFSYNLQGKDNELLVFKHRIGEYSLYIGKTKVTFKVREVFPRPVHICTSWESSTGIAEFWINGEPLVKKGLRQGYSVGAYPRIVLGQEQDSYGGGFDKTQSFVGEIGDLYMWGSVLSPNEIRLVYQGLSFPHPTILDWQALNYEMNGYVVIKPRVWS
What are the official names of this protein?
Serum amyloid P-component, SAP.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSI_SODGM
Sequence: MSEQQPKAKFSDNERLKGESRFLRGTIAQDLQDGLTGGFNGDNFQLIRFHGMYQQDDRDLRAERAEEKLEPLINMMLRCRLPGGVITPQQWLGIDAFAAEQTLYGSIRLTTRQTFQFHGVLKPKLKGMHQLLHCLGLDSIATAGDVNRNVLCTSNPVESVLHRQAWEWAKKISEHLLPKTRAYAEIWLDGEKTETTDQEPILGPTYLPRKFKTTVVVPPLNDVDLHANDLNFVAISDNGQLVGFNVLVGGGLAMTHGDKSTYPRKASEFGFIALDDTLKIAEAVVTTQRDWGNRSNRKNAKTKYTLESEGVGAFREEVEVRAGVQFAPIRPYAFTERGDRFGWVKGIDNQWHLTLFIENGRILDYPDRTLKTGLAEIARRHKGDFRLTANQNLIIAGVDKKDKAAIEALARRHGLINDDATPQRKASMACVAFPTCPLAMAEAERFLPQFVSNVETIMSGHGLAEDEIILRVTGCSNGCGRAMLAEIGLVGKAIGRYNLYLGGDRIGTRIPRIYRENITEDEILSIIDDTAGRWARERQPQESYGDYLVRAGIVRPVVDSARDFYD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: OXYR_ECO57
Sequence: MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANRECVPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLLPALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV
What is the function of this protein?
Hydrogen peroxide sensor.  Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA.  OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence.  OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR.  Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability (By similarity).
What are the official names of this protein?
Hydrogen peroxide-inducible genes activator, Morphology and auto-aggregation control protein.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: ADEC_EDWI9
Sequence: MEDIHHKHTQSVSRSDMLRLLAVSRGDQPADLIIDNVFLLDLINGGTLPGPILISGDSIAGVGPAYAGTAALERIDAGGAIAVPGFIDAHLHIESSMMTPIAFESVTLPLGVTTIVCDPHEIVNVMGEKGLTWFLRCAEGAQQNQFIQISSCVPALAGTDINGAEFPLTAMLPYREHPHVLGLAEMMNFPGVIAGDEPTLDKLDAFRHLTLDGHSPMLSGKALNAYLAAGVENCHETLALEEGREKLALGMALMIREGSAARNLDTLAPLISEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIQRHHIAPHVAYRVASWSAARHFGLKRLGLIAPGKKADIVLLDNLEQVAIRQVFAGGKAIDAQQLLRSAAMRQLASCPPQHNTLRRAPLSAEDLTLPLTQDADYRAIQLIPNELITPARTVRWLGDGFDTPDVCRIAVMERYGQQRVPALGLLHNSGLSKGALAATVSHDSHNIVVIGHHPAEMALAVNQLIDDGGGLCVVADGQVVVHLPLPIAGLMSSRSAAEIADIIDALKQACRNCGMTLNEPFIQMAFLSLPVIPSLKLTSLGLYDVDHFRFTEVRIPEESA
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.