PharMolix/UniProtQA huggingface dataset:
Protein: GCSH_STRCO
Sequence: MSNPQQLRYSKEHEWLSGAEDGVSTVGITEHAANALGDVVFVQLPEVGDSVTAGETCGELESTKSVSDLYSPVSGEITEVNEDVVNDPSLVNSAPFEGGWLFKVRITDEPADLLSADEYTAFAGA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SMOX_MOUSE
Sequence: MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNMTQEFFRHGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPPHVIQLGKPVRCIHWDQASAHPRGPEIEPRGEGDHNHDTGEGGQSGENPQQGRWDEDEPWPVVVECEDCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP
What is the function of this protein?
Flavoenzyme which catalyzes the oxidation of spermine to spermidine.  Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions.  Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.  May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
What are the official names of this protein?
Spermine oxidase, Polyamine oxidase 1, PAO-1, PAOh1.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Protein: YLK5_CAEEL
Sequence: MDRGGGSIRNCRLAQKWDDSFRPIATSIHGGPEKGHMESNPVLNIHVPFFTDCAAAPAIKLSTVVLST
What are the official names of this protein?
Uncharacterized protein D1044.5.
Protein: RL25_BORBR
Sequence: MKFNATARSVQGSSASRRLRRAGRVPAIVYGGTAAPLNIELDHNEIYHALRKEEFHASILNMVIEGGKTEEVLLRSVQWHAYKPQVMHVDFQRVDANQALHTKVPLHFINAEVSPAVKLSGAIISHVLTELDITCLPALLPQFIEVNLGDLLGGGSIHLADIKLPKGVTFNAHGGDTNPLIAAAVVKGGGAADEGDAAAEQPAA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: YD426_YEAST
Sequence: MYIYIYIYVYAICNTMRDGNAFYRASSICNFASFQFFRHSLIHALKLAAKSFKIFPMVKLIWLYVCIKLLYDELLISSMSDIQIDRQSFNLDKSWFNCLICLDLSCSVNCLISNLLRFIVGVDVL
What are the official names of this protein?
Putative uncharacterized protein YDR426C.
Protein: NADK_CHLCH
Sequence: MNFGIVVNISREQALHLARTLATWFDERHIGYMFETLSGSTLGLGPSAPIEELNCHCDVFISLGGDGTLLFTSHHAVTKPVIGINVGYLGFLAEFTQSEMFAAVEKVLSGNYSLHTRSQLEATAFMDGVSHQFRALNDAVLEKGTYPRIPAFIIKLDGELLSAYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVISDDKVIEISVDAPDGEFPLNCDGSLKKMLAPHECITIKKSPVAINLVANEKRNYGEILRTKLLWGREHDGCCS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP72_DROME
Sequence: MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD
What are the official names of this protein?
Major heat shock 70 kDa protein Ba, Heat shock protein 70Ba, HSP70-87C1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: SYR_XYLFA
Sequence: MKAPLRALICQGIEALRSNGTLPTNTLPPDFVVERPKTRKHGDFATNVAMLLSKATGSNPRLLAQTLVAALPTSADIARIEIAGPGFINFHLHPVAYQRETINVLKQDNDYGRNLSGQSRTVGVEYVSANPTGPLHVGHGRAAAIGDCLARLLEANGWNVKREFYYNDAGVQIENLVRSVQARARGLKPGDAFWPTDAYNGEYIADIAKAYLAGDSINMVDTIITSTKNVDDTAAIHHFAVNYLRNEQNHDLAAFNVDFDIYFLESSLYKDGKVEETVQKLINSGHTYEEGGALWLKSTHFGDDKDRVMRKSDGSYTYFVPDIAYHLSKWQRGYERAITELGADHHGSLARVHAGLQALEIGIPPGWPEYVLHQMVTVMRGGEEVKLSKRSGGYVTLRDLIEETSTDATRWFLIARKPDSQLTFDIDLARQKSNDNPVFYVQYAYARVCSLMHQAHEKNLNYDQTSGMASLDQLSDNTSLCLMIEISRYPEIVQIACELLEPHLIAQYLRELAHAFHTWYHNTPVLVENAVERNAKLTLACATRQVLANGLNLLGVGTPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHSA3_XENLA
Sequence: MRLLGCFFLIFLTWGSARAQGEYCHGWLDSAGNYQAGFQCPEDFDTADANICCGSCALRYCCAAADARLEQGSCTNHRELEKSGVSAQPVYVPFLIVGSIFIAFIIVGSLVAVYCCTCLRPKQTSQQPMRFTLRSYPPETLPMILTSGNLRTPSRQSSTATSSTSTGGSVRRLSSSRADPGYLVSSPPPPYSSAHSIHLNPSSTFLVSNQYFPYPLQPEAIANKSCPDFRQS
What is the function of this protein?
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both fgf and wnt signaling.  Regulates head and somite developmen.  Inhibits both wnt and fgf signaling through the regulation of protein maturation and cell surface transportation of their receptors within the endoplasmic reticulum.
What are the official names of this protein?
Protein shisa-3.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: HLYS2_HYDVD
Sequence: MGKELLTFSDLTWLDSSPDTVRSAFTRQYGTTPDGIALNSEGYFGYHSPPITEQYGRPCYKQTGETKITLQDLAPPTDAILGNSIARNRGDSPITLTVSVEGKWSDSTSWSTSTETGVKMSSEFGVEGAFKMGGEFSLTVSVGKSGSSSVEKTSTSSVQVTVPPRSKVVVSMVGIMKKEKVFFEVPVTVDGSFGANFPSTVQGHYFWFMDARSCLNKTSGVIKGTIDHANVFDVSVEVGPSEPL
What is the function of this protein?
Induces an immediate fast muscle contraction followed by flaccid paralysis when injected into blowfly larvae.  Has strong cytolytic activity against insect Sf9 cells and human HeLa cells, weak activity against human JAR cells, and no activity against human HEK293 cells.  Binds to erythrocyte membranes and has hemolytic activity, probably mediated by oligomerization and pore formation.
What are the official names of this protein?
Hydralysin-2.
What is the protein family that this protein belongs to?
Belongs to the hydralysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AL221_ARATH
Sequence: MPFWWPLIVLAFAYAICKFLLMLIPPNVPSIDVDASDVLAHGKDTEENSFIYIPPRGRSQQSDKKVQCYEPATMKYLGYFPALSPTEVEERVTLSRKAQKTWAQSSFKLRRQFLRILLKYIIEHQELICEVSSRDTGKTMVDASLGEIMTTCEKITWLLSEGERWLKPESRSSGRAMLHKVSRVEFHPLGVIGAIVPWNYPFHNIFNPMLAAVFSGNGIVIKVSEHASWSGCFYFRIIQAALAAVGAPENLVDVITGFAETGEALVSSVDKMIFVGSTAVGKMIMRNAAETLTPVTLELGGKDAFIICEDADVSHVAQVAVRGTLQSSGQNCAGAERFYVHKDIYTAFIGQVTKIVKSVSAGPPLTGRYDMGAICLQEHSEHLQSLVNDALDKGAEIAVRGSFGHLGEDAVDQYFPPTVLINVNHNMKIMKEEAFGPIMPIMQFSTDEEVIKLANDSRYALGCAVFSGSKHRAKQIASQIQCGVAAINDFASNYMCQSLPFGGVKDSGFGRFAGIEGLRACCLVKSVVEDRFWPLIKTKIPKPIQYPVAENAFEFQEALVETLYGLNIWDRLRSLIDVLKFLTDQSSNVSRTRKSH
What are the official names of this protein?
Aldehyde dehydrogenase 22A1, Novel aldehyde dehydrogenase family 22 member A1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y041_OSHVF
Sequence: MTNMILLSAVFLSLAILETHCANHISTGISTAGEVEIRCVSDNYVKKIMAYNRDRLSDATISIIQNYKQGPYGCDGVAQSSVISGAAKEKRINTPECITTGRIGGLIVRLKSKPKEEDLGKWECYFTDLTDNVDSKTLTDVLTKYNLPNSGYFNADGTPNDFTTELKVLDYDDVTKDVIMGCKLSTDLGTPPTMSDKQPYRSVHLTGDDRYYAEGDLYSRTSFSSTPYDCTGIPQNTNKYLYNCFNVAPNEYRSAAHRPPPFIALTAPSTPSNIILDNVAEKHAFTKHFFFPAEDKAVVDLRGKNVVISPLAVSDYTQIKMKYLSVQNAVFSPPEELINKLGEVLLKELSTATKFEIVNVDNNFAPTIPGDPYKMVMIADQSCVSGVNKNVIYTGLCKKSSSMSVITMTYFSSLDCDKTSHYAYIFYTGNEPREVEILPAGIQEAVGTPPDVTASNIPENSGGNDCESTTAQDVAEKLFGHLQTVCPTIPLCQMPSTVRTVITDGECAQRPFICNNRALVEYHVPLTELTSGSPFANDWSCTAVDKQSPMKTWHKGLRTELACGLGDLKQKYIDNSLPLIVKQGEDSYKVVCSTPPSLCTDNGLTPPRLNKDDKTYTKEELMAPDDYACTDHFDRVEVKKSYELIQDHFGCEYKLYCKITPHNVRCYITNFPQCQTPAYISGTIGSDTIPNTALTPESLSVMFIKGGLVSTTSLDLSIWTIKGIKLAQFTTAADLPDACELAANNIQVTHNMDFTSAGKTVTFTCINKLPLDNTCDISAGHSKDTRYKLEISNDGSNWVALAESTLAIDGSGVKTLTSTFSKEGGIFAEGDGVFSFLFYSLNDDAIRTMYTDRSNIQARCVKMFDSSSSTSTIKAVDYISYDTYRKSLVPKEPTVTTTTESPPPPTTTTRQIHSKEDFDRVKKELGEKLYHVLFFMGVLTVSVAGGVIILSFIGCLIMRKMEDAPQKTKYSV
What are the official names of this protein?
Uncharacterized protein ORF41.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: PPK4_CELBM
Sequence: DHMSHDVYSPRL
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Pyrokinin-4, Cel-PK-4, YXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMN6_YERPY
Sequence: MVTNVGEQLKKQPVLRGGGFTFKQFFVAHDRCAMKVGTDGVLLGAWVPVLHARRVLDIGCGSGLIALMIAQRSLPQVQIDGVELEPAAAQQASSNVELSPWAERIHIHQQDIHQFAENHPHQYDLIVSNPPYFAPAIACRDEARDTARYTGSLTHDTLLNCAEKLITEDGMFCVVLPHELGIEFARLAGQQGWFVRCQVDIRDRPGKPLHRMLLTLSRQAGETVYQHLALRQSEGVYSPEFCQLISDFYLNY
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEN18_PENRB
Sequence: MKGFLSLTLLPLLVAASPVAVNSIHNDAAPILSSMTSKDIPDSYIVVFKKHVDPSSASAHQSWLQEVHTAHTGRMELKKRSLFGFDFEAFMGLKHTFHIAGSLLGYAGHFHEDVIEQIRRHPDVDYIEKDSEVRTMSEGSVEKNAPWGLARISHRESLSFGNFNKYLYAEEGGEGVDAYVIDTGANVKHVDFEGRANWGKTIPQGDADEDGNGHGTHCSGTIAGKKFGVAKKANVYAVKVLRSNGSGTMSDVVKGVEWAAEAHIKKSKKGDKKFKGSVANMSLGGGSSRTLDLAVNAAVDAGIHFAVAAGNDNADACNYSPAAAEKAITVGASTLADERAYFSNYGKCTDIFAPGLNILSTWVGSDHATNTISGTSMASPHIAGLLAYYVSLAPAKDSAYAVADVTPKQLKAALISVATEGTLTDIPSDTPNLLAWNGGGSANYTKILADGGYKAHNAETTVEDRIGIIIDSAEKAFHKELGAIYSEIKDAVSV
What is the function of this protein?
Serine protease.
What are the official names of this protein?
Subtilisin-like serine protease Pen ch 18.0101, Allergen Pen n 18, Vacuolar serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: ATPF_COFAR
Sequence: MKNVTDSFLSLGHWPFAGSFGFFNTDILSTNLINLSVVLGVLIFFGKGVCASCLLSDLLDNRKQRILNTIRNSEELRGGAIEQLEKARTRLRKVEMEADQFRVNGYSEIEREKLNLINSIYKTLEQLENYKNETIQFEQQRTINQVRQRVFQQALQGALGTLNSCLNNELHLRTISANIGILGSIKEKTD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: APOB_CHICK
Sequence: IPGLSEKYTGEELYLMTTEKAAKTADICLSKLQEYFDALIAAISELEVRVPASETILRGRNVLDQIKEMLKHLQEKIRQTFVTLQEADFAGKLNRLKQVVQKTFQKAGNMVRSLQSKNFEDIKVQMQQLYKDAMASDYAHKLRSLAENVKKYISQIKNFSQKTLQKLSENLQQLVLYIKALREEYFDPTTLGWSVKYYEVEDKVLGLLKNLMDTLVIWYNEYAKDLSDLVTRLTDQVRELVENYRQEYYDLITDVEGKGRQKVMELSSAAQEKIRYWSAVAKRKINEHNRQVKAKLQEIYGQLSDSQEKLINVAKMLIDLTVEKYSTFMKYIFELLRWFEQATADSIKPYIAVREGELRIDVPFDWEYINQMPQKSREALRNKVELTRALIQQGVEQGTRKWEEMQAFIDEQLATEQLSFQQIVENIQKRMKT
What is the function of this protein?
Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL.  It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
What are the official names of this protein?
Apolipoprotein B.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Lipid droplet.
Protein: MUTL_PSEFS
Sequence: MNSGSRIELLSPRLANQIAAGEVVERPASVIKELLENSIDSGAKRIDVDVEQGGVKLLRVRDDGSGISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFNTPARRKFLKAEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVSAICGAGFLEQALPIEIERNGLRLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFVLFFEVDPSVVDVNVHPTKHEVRFRDGRMVHDFLYGTLHRTLGDVRPDDQLSAPIVTAVVRPSGPEAGEFGPQGEMSLAANLLQSPQPQPSYTAPGSGSGAGYQYQYTPRPQSAVPVAEAQAAYREFFAPLPGAEPGAPVALPEGGGDIPPLGYALAQLKGIYILAENAHGLVLVDMHAAHERIMYERLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHHSVFQKLGFELQRLGPETLAIRQIPALLKQAEANRLVADVLADLMEYGTSDRIQAHINELLGTMACHGAIRANRRLALPEMNGLLRDMENTERSGQCNHGRPTWTQMGLDDLDKLFLRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: YCF20_GUITH
Sequence: MRLFFYNLLTILFGFFLSTLLSTILSQTGDWSILAASILVATIELINKNKYKKKPLIIGLVLTI
What are the official names of this protein?
Uncharacterized protein ycf20.
What is the protein family that this protein belongs to?
Belongs to the ycf20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y950_LYSSC
Sequence: MANEFKVCDECQAVNLKTLIPKLKEIDPDATIEIGCHSYCGPGRKKTFTFVNSRPVAALTEEELMEKVLTKLKNK
What are the official names of this protein?
UPF0741 protein Bsph_0950.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: DVL10_ARATH
Sequence: MCLFMSNSSLPTKPNRKTRFGDRCLLMAKQQRTRLYILRRCVSMLLCWHDHSISD
What is the function of this protein?
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
What are the official names of this protein?
Small polypeptide DEVIL 10, Small polypeptide ROTUNDIFOLIA LIKE 12, Small polypeptide ROT-FOUR-LIKE 12.
What is the protein family that this protein belongs to?
Belongs to the DVL/RTFL small polypeptides family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YIPF5_MOUSE
Sequence: MSGFDNLNSGFYQTSYSIDEQSQQSYDYGGSGGPYSKQYAGCDYSQQGRFVPPDMMQPQQTYTGQIYQPTQAYPPTTPQPFYGDSFEEEPPLLEELGINFDHIWQKTLTVLHPLRAADGSIMNETDLAGPVVFCLAFGATLLLAGKIQFGYVYGISAIGCLGMFCLLNLMSMTGVSFGCVASVLGYCLLPMILLSSFAVVFSLQGMVGILLTATIIGWCSFSASKIFISALAMDGQQLLVAYPCALLYGVFALISVF
What is the function of this protein?
Plays a role in transport between endoplasmic reticulum and Golgi.  In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.
What are the official names of this protein?
Protein YIPF5, YIP1 family member 5, YPT-interacting protein 1 A.
What is the protein family that this protein belongs to?
Belongs to the YIP1 family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched at the endoplasmic reticulum exit sites (PubMed:15254263). Incorporated into COPII coated vesicles (By similarity).
Protein: RPIB_MYCTO
Sequence: MSGMRVYLGADHAGYELKQRIIEHLKQTGHEPIDCGALRYDADDDYPAFCIAAATRTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVQTAALAREHNNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAQRHQRRIDILAEYERTHEAPPVPGAPA
What is the function of this protein?
Catalyzes the interconversion of ribulose-5-P and ribose-5-P.
What are the official names of this protein?
Ribose-5-phosphate isomerase B, Phosphoriboisomerase B.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: BIOW_BACA1
Sequence: MREEKFYSVRMRASKNGSHEVGGKHLSGGERLTTYENMIHTVNALLEKGIYHSRGKPDFMKIQFECIDEPIQLVNPLHIETHEVESAEKGQVLARKLLEKAGIQKKMIDLAYEQIPECSGLRGAILFDIHSGKRIDQRKERGVRVSRMDWPDTNFDKWTKCYQMPRNSRIKEALVLATKVSEHPATIAELCWSDDPDYITGYVASKKLGYQRITKLKEYGNESGCRIFFVDGLRDLETYIDYLEKQPVFIQWEEENDA
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: DPO4_STRP6
Sequence: MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGDQIRRIFKRYTDVVEPMSIDEAYLDVTNNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKFLAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKARGISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLDL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_DINSH
Sequence: MTQITPQPGIMDIALYEGGASKVDGLDTVIKLSSNENPLGPSPAAIAAYKAAAGELHRYPSTDHAGLRGAIAEVYGLDPERIICGAGSDEIIAFLCQAYVGPGDEVIHTEHGFAMYRISTLAAGGTPVEVPERERVTDVDAILAGVTDRTRLVFIANPNNPTGTMIGGNALARLADGLPEGCLLVLDGAYAEYVPDYDAGKALVESRENVVMTRTFSKIYGLGALRVGWGYGPRHVIDVLNRVRGPFNLSTGALAAAEAAVRDRAYTETCRAENAKWRGWLASELAALGIPSDTSSANFVLARFASPEEAGACDDFLKARGIIVRRVSGYKLPAALRMTVGDAEGCRALVDAVAAFKAQAA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: UBIB_AERS4
Sequence: MTPKEFKRLYRIITILLEQGIDELVPARYQPWPGRLARRSLFWLKKKQPDLSRGARIRLAFEALGPIFIKFGQMLSTRRDLLPPDIAEELAMLQDRVPPFCGQAARLKIEESLGCPVETLFDDFDETPLASASIAQVHTGRLKENGREIVIKVIRPDIEPVIEADLRLMQTLARLVARFVPQSARLRPIEVVEEYRKTILDELNLMREAANAIQLRRNFTGSDALYVPEVFTEHCREHVLVMERIYGIPVSDIPALEANGTNMKLLAERGVEVFFTQVFRDSFFHADMHPGNIFVSYEHPDNPLWIGIDCGIVGTLNREDKRYLAENFLAFFNRDYRRVAELHVESGWVPPDTKVDEFEFAIRTVLEPIFEKPLSEISFGHVLLNLFNTARRFNMAVQPQLVLLQKTLLYVEGLGRQLYPQLDLWQTAKPYLENWMHEQVGPKAVWNAIKEKAPFWAEKLPELPELVYETLRQTRHQQRHFDQMFADFRRHSRRQGQARYLLGVGASLLLVGVFLLTQKQHIEWGQISLAGAGLCWLLGWFKARSH
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TGFR2_RAT
Sequence: MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSVNSDLMAGDNSGAVKLPQLCKFCDVTLSTCDNQKSCMSNCSVTSICEKPQEVCVAVWRKNDKNITLETVCHDPKFTYHGFTLEDATSPTCVMKEKKRAGETFFMCSCNTEECNDYIIFNEEYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIAIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTEMGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPDRLSGRSCSQEKIPEDGSLNTTK
What is the function of this protein?
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.  Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2.  Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.  The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes.  This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.  Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
What are the official names of this protein?
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft.
Protein: SYA_RHIME
Sequence: MSGVNEIRSMFLDYFRKNGHEIVSSSPLVPRNDPTLMFTNAGMVQFKNVFTGLEQRPYSTAATAQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKERAIELAWNLITKEYGLDAKRLLVTVYHTDDEAFGLWKKIAGLSDDRIIRIATSDNFWAMGDTGPCGPCSEIFYDHGDHIWGGPPGSAEEDGDRFIEIWNLVFMQYEQITKEERVDLPRPSIDTGMGLERVAAVLQGQHDNYDIDLFRALIAASEEATGVKAEGDRRASHRVIADHLRSSAFLIADGVLPSNEGRGYVLRRIMRRAMRHAQLLGARDPLMWKLLPALVGQMGRAYPELVRAEALISETLKLEETRFRKTLERGLNLLAEASADLSEGDQFNGETAFKLYDTYGFPLDLTQDALRAKGIGVDTDAFTAAMQRQKAEARANWAGSGEAATETIWFELRDKHGATDFLGYDTESAEGVILAIVKDGAVVESAAKGENVQLVLNQTPFYGESGGQVGDTGVITTETGKLTVTDTQKRGEGLFVHYCTVEEGSVKTGEAAALTVDHARRARLRANHSATHLLHEALREVLGTHVAQKGSLVAPERLRFDVSHPKPMTAEELKIVEEMANEIIVQNTPVVTRLMSVDDAIAEGAMALFGEKYGDEVRVVSMGQGLRGSKAGKPYSVELCGGTHVSATGDIGLVRVVSESAVGAGVRRVEALTGEAARAYLGEQDERVKTLAAALKVQPADVLGRVEALLDERRKLERELTEAKKKLALAGDGQNGSGDAARDIGGVRFLGRVVSGVEPKDLKSLADDGKKSLGSGVVAFVGVSGDGKASAVVAVTDDLTSKVSAVDLVRVASAALGGKGGGGRPDMAQAGGPDGGRAAEAIEAVAGALAG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.