PharMolix/UniProtQA huggingface dataset:
Protein: SYP_LIMRD
Sequence: MKQSKVLIPTKKEAPSDAEALSHKMMIRAGYIYQVSAGVWSYLPLAYRVIRKVENIIRDEMDKAGAVEMLMPGLLPADLWKESGRYESYGDNLFKLKDRRDRDFILGPTHEETFTEVLRDSIKSYKKLPLVVYQLQDKFRDEDRPRYGILRGKEFEMLDGYSFSADQEGLDEAYNNQAKAYRNIFDRIGLNYKVILADSGTMGGKNSQEFSAPAEVGEDIIAYTDGDYAANIEKAESKFTGVQQTAVPAPIEKKATPGAHTVYEAAESLDLDPNQVIKSMLYIAKMSEDEYQPVLVLMRGDDEVNEAKVINALDCEELELATEEDAEKYLNAHPGSLGPVGVGEEVKILADNYVKVLVNMACGANEDGYHYVNANIDRDFRVDQFGDFRNVKEGEIAPDGQPLKFTPGIEIGHIFKLGTHYSSKLGAQVLDSNGRLTDVIMGSYGIGVTRLLSAVAEQNADENGLVWPDSIAPFDVHVIPVNAKKEDQMAMADKIDQQLTEAGYEVLVDDRKERAGVKFADSDLIGIPIRVTVGKKAQDGIVEIKIRKTGETVEVKQEELVNTVGILLKQLNEEKNK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDPK9_ARATH
Sequence: MGNCFAKNHGLMKPQQNGNTTRSVEVGVTNQDPPSYTPQARTTQQPEKPGSVNSQPPPWRAAAAAPGLSPKTTTKSNSILENAFEDVKLFYTLGKELGRGQFGVTYLCTENSTGKKYACKSISKKKLVTKADKDDMRREIQIMQHLSGQPNIVEFKGAYEDEKAVNLVMELCAGGELFDRIIAKGHYTERAAASVCRQIVNVVKICHFMGVLHRDLKPENFLLSSKDEKALIKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLRRRYGKEVDIWSAGIILYILLSGVPPFWAETEKGIFDAILEGHIDFESQPWPSISSSAKDLVRRMLTADPKRRISAADVLQHPWLREGGEASDKPIDSAVLSRMKQFRAMNKLKKLALKVIAENIDTEEIQGLKAMFANIDTDNSGTITYEELKEGLAKLGSKLTEAEVKQLMDAADVDGNGSIDYIEFITATMHRHRLESNENLYKAFQHFDKDSSGYITIDELESALKEYGMGDDATIKEVLSDVDSDNDGRINYEEFCAMMRSGNPQQQQPRLF
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase 9, Calmodulin-domain protein kinase CDPK isoform 9.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ARGB_LACLM
Sequence: MRDSQNTAQTLTESLKYFLKYRDQTVVIKYGGNAMIDEKVKESILKDILLLKTVGIKVVLVHGGGPAIGELLEKYEQKSQFVQGLRVTDKKTAQLALTALAGKVNKSLVQDIIRLGGNAIGVSGIDGKLIEAKPISEDLGYVGEITAIHPEIIERINQTDAVPVIASAGIGLDGEIYNVNADTAASRIAGALSAEQFILLSDVRGLYGNFPDEESFIDEINLTNLEKLVKEKKITDGMIPKIEAIKYAMFEGLGQAVLLDGRVPHALLLELFTDKGQGTMINH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_PSEA6
Sequence: MALLQIAEPGLSAAPHQRKLAVGIDLGTTNSLVATVRSGQAETLGDNNNQHLLPSVVSYTAEQVVVGEQAKHDASLDPANTIVSVKRFLGRSLNDIRRSYPDLPYDFDESNPNSPLLNVTGRQVNPVEVSSEILTTLRLRAEQSLGEELSGAVVTVPAYFDDAQRQGTKDAAQLAGLKVLRLLNEPTAAAIAYGLDTAQEGVIAVYDLGGGTFDISILRLSKGVFEVLATGGDSALGGDDFDHMIVKHFRQQLGLEGALSKRLHRVLLDKAKFAKESLSDNDTVTVDFADDEQKLLSLSISRETFQGLIADLTKSTLRACRRALKDAELEKDEVLEVVMVGGSTRVPYVREQVGEFFGRTPLTSIDPDKVVAIGASIQADILVGNKPDGEMLLLDVLPLSLGLETMGGLVEKVIHRNTTIPVAKAQEFTTFKDGQTAMMIHVLQGERELVDDCRSLAKFTLHGIPPMAAGAAHIRVTFQVDADGLLNVMAMEKSSGVQAEIQVKPSYGLDESQISDMLKASMQNATGDMQARMLKEQQVEAARVHEALQAALNADGAELLSAAEIGTIQASLEVLDIAGKNDDIDAIKQAISAADAASQIFAEKRMDHSIKKALAGHTVDSI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: KISS1_MACMU
Sequence: SVENSRPTGQQLESLDLSAPWEQSLPCTERKPSATARLSRRGASLSSPAESSGSPQRRGLSAPSSRQIPAPQGAVLVQREKDLPNYNW
What is the function of this protein?
Metastasis suppressor protein.  May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.  Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.  The receptor is essential for normal gonadotropin-released hormone physiology and for puberty.  The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
What are the official names of this protein?
Metastasis-suppressor KiSS-1, Kisspeptin-1.
What is the protein family that this protein belongs to?
Belongs to the KISS1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27_CELJU
Sequence: MAHKKGVGSSRNGRDSEAKRLGVKAFGGELVSGGSIIVRQRGTKFHAGENTGLGKDHTIYAKVDGRVKFEVKGAFGRQYVSIIPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PANB_ACISJ
Sequence: MTDSPTAGTPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVADAAGVECILVGDSLGMVCQGLPSTVGVTLEHMAYHTASVARGLHRVQGTAWLIADLPYGSYAESREQALRSACQLMQAGAHMVKLEGGGWTAPTVQFLVERGVPVCAHLGLTPQTVHALGGYRVQGKGDQAAQQLRRQALELQDAGAAMLVLEMVPTPLARDLTQALPRCHTIGIGAGSGTAGQVLVMHDMLGINLGKNPKFVHDFMRDAGSVRGAIEAYVQAVKQGRFPDDALHAWN
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLA10_CHLRE
Sequence: MPPAGGGSESVKVVVRCRPLNGKEKADGRSRIVDMDVDAGQVKVRNPKADASEPPKAFTFDQVYDWNCQQRDVFDITARPLIDSCIEGYNGTIFAYGQTGTGKSHTMEGKDEPPELRGLIPNTFRYVFEIIARDSGTKEFLVRSSYLEIYNEEVRDLLGKDHSKKMELKESPDRGVYVKDLSQFVCKNYEEMNKVLLAGKDNRQVGATLMNQDSSRSHSIFTITIECIEKLESAAAQKPGAKKDDSNHVRVGKLNLVDLAGSERQDKTGATGDRLKEGIKINLSLTALGNVISALVDGKSGHIPYRDSKLTRLLQDSLGGNTKTVMVANIGPADWNYDETMSTLRYANRAKNIQNKPKINEDPKDAMLRQFQEEIKKLKEQLAARAAGGGGPITMPSGGGSPTQKIVERTEEVDPDIDAIKAQMRAELEAKMKSDISTEALDKAREEAEAAAKKQLQAIIDDQGKTEAQKKAARDALKKQAEEARAIAGAIEKEKQEKAVLESRIKEMEGKIVVGGVNMLEKVDELKQKSEDIKREAAIRKRQEEEAKRRLEELQAAQVDADAKFASLDEEINVKSRQLKKLFEKYQGKKGELADLQEQFQREREGMLEDYRILTQQIKLKNLIIACFIPPDYQDKIMQHCHWQDYDSSWNIDCIAYAGNAVRTNQELQAQEDKEHDAAAENERLKNCFFSYEQFEAAGAGSKQGGGGGGGGGGAARPGSSAGRAVGSAARRTGGKAGGKDITDIGSLRDSVNWGDDDDKKKGAIPKAKGLVKDTVDPRLRASKLK
What is the function of this protein?
Probably involved in flagellar assembly and maintenance.  May play a role in flagellar synthesis.
What are the official names of this protein?
Kinesin-like protein FLA10, Protein KHP1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATM1_ASHGO
Sequence: MFRLLRFSPSRYYPRSMAPVRWSTHPYHVTAPRMWGTRMPLQLQASLRPNNAVEKGISGDVKVAGAMVKPAASGGESAKSKTPTVSELKILKDLFRYIWPRGDRKVKTRVLIALGLLLGSKLLNVQVPFFFKSTVDSMNIEWGDVGTALPIAVTLTVLSYGAARFGAVLFVELRNAVFSNVAQSAITKVSLQTFQHLMKLDLGWHLSRQTGGLTRAMDRGCKGISYVLSAMVFHIIPITFEISMVCGILTYQFGASFAAITFSTMLLYSIFTFRTTAWRTRFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYHTSLMKYRDSQIKVSQSLAFLNTGQNLIFTTALTAMMYMACNGVMQGSLTVGDLVLINQLVFQLSVPLNFLGSVYRDLKQSLIDMESLFKLQKNQVTIKNSPNAQNLPIHKPLDIRFENVTFGYDPERRILNNVSFTIPAGMKTAIVGPSGSGKSTILKLVFRFYEPEQGRILVGGTDIRDLDLLSLRKAIGVVPQDTPLFNDTIWENVKFGNISSSDDEILRAIEKAQLTKLLQNLPKGASTVVGERGLMISGGEKQRLAIARVLLKDAPLMFFDEATSALDTHTEQALLHTIQQNFSSNSKTSVYVAHRLRTIADADKIIVLEQGSVREEGTHSSLLASQGSLYRGLWDIQENLTLPERPEQSTGSQHA
What is the function of this protein?
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity).  Hydrolyzes ATP (By similarity).  Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).
What are the official names of this protein?
Iron-sulfur clusters transporter ATM1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YON8_SCHPO
Sequence: MLLPSIPSCSFSFVVFVSVLLQTCFSFQLTPLSPKNYPPGASIDTTVNTISPFIGDGRGSDIFNYEYYDERFHFCRPENIAKQSESLGSVLFGDRLYNSPIEIKMLENQDCVPLCASIIPSSDVSFIRDLISKNYVVNWNIDNLPVATYLEGTNSKNYSLSPGFPLGKNTEKGVILFNHYDIVIEYHTTSSDQHRVVGAYVKPVSKESTLVDGNPVCSSSSNPQYLPEGADLTLVTSYSVSWKYSDTPWATRWDKYMHIESRQIRWIFIIHSAIIDTFLIFVVSIILYRTLNRDINKYNSAFVDQEDVQEDFGWKLVHGDVFRPPRRPMLFSILLGTGAQLLFMSSGIVLFAIFGIVAPSRRGSLATATVALFIISGFVSGYVSALSYKLMQGMLRKRNLLLTPFVVPGFMLAAALFFNMVFWSKSSSSTVPFSSWLLLIFLYLLFTVPLSFVGSLIGFRSREFVPPVRTNQIPRQIPSHSIWLSSFPSAIIGGSIPFLVILIELFSILDSLWFHPLYFMFGFSFFCFGILVTTCIMVSIITVYFQLCSENYNWWWRSFITPGFCGIYVFIFSVFYWFFKISSSSLATAVLYFGYSLLISVLVFFLCGSVGFFGAFLFVNKIYASIKID
What are the official names of this protein?
Transmembrane 9 superfamily protein C1105.08.
What is the protein family that this protein belongs to?
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: CAIC_SALCH
Sequence: MDIVGGQNLRQMWDDLAGVYGDKTALIFESCEGIVRQFSYASLNEEINRTANLFYSLGIRKGDRVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLGEESAWILQNSQVSLLVTSVQFYPMYREIRQDNSTPLNHICLIGEQLPADDGVSHFSQLQARQSATLCYTPALSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQIALRDDDVYMTVMPAFHIDCQCTAAMPAFSAGSTFVLLEKYSARAFWDQVRRYQATVTECIPMMIRTLMVQPAAPTDRQHHLREVMFYLNLSAQEKDAFTERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFSYEAEIRDDQNRPLPAGEIGEICIKGIPGKTIFKEYYMQPEATAGALEPEGWLHTGDSGYQDEDGYFYFVDRRCNMIKRGGENVSCVELENIISAHPKIQDIVVVGIKDAIRDEAIKAFIVLNEGETLSEAEFFSFCENNMAKFKVPSFMEIRTDLPRNCSGKIIKKNLK
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CHEB_SALCH
Sequence: MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYSEMIAEKVRTAARARIAAHKPMAAPATLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPAVIITQHMPPGFTRSFAERLNKLCQISVKEAEDGERVLPGHAYIAPGDKHMELARSGANYQIKIHDGPPVNRHRPSVDVLFHSVAKHAGRNAVGVILTGMGNDGAAGMLAMYQAGAWTIAQNEASCVVFGMPREAINMGGVSEVVDLSQVSQQMLAKISAGQAIRI
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXE03_LYCSI
Sequence: MNSKVFVVLLLLALSTCVLSEKYCPTPRNTSCKKMNIRNNCCRDSDCTSNAFCCAEPCGNFCHKASDKPGGRRVDPNASCKTGYVYW
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
U14-lycotoxin-Ls1b, Toxin-like structure LSTX-N3.
What is the protein family that this protein belongs to?
Belongs to the venom protein 11 family. 01 (wap-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MAM1_SCHPO
Sequence: MHIHSDLSLPQFEHASIDPPSYSPQKSSFEEKKHNFSITNKSLETLRSQESPCSTTFPVSDRKDALLNIPTVVDDEFQHTEELAGVSSWSDFFYLFHFSDIPLIFGTLIFTCLSAALEPLMTWTTGKVFDALSQYATSQITLGKMISLINFNSLLITIFGLASCVFSFGVRFLWQYLSAIAGKRARSLCFHVLSSKSSTFYSLTESKSGLVNSVDRCIQFYEKSISLPMFHIAENLAISLSCLIISFRYSWSLTLVVLASYPIIILVVGFINSFLSSAYEKDRKSSEKAASILEKSISAIQTVIFHSMQDTEYRYFADACSTSSKSFLRFSFLDAFQGGVSQFFLYSVFFQGLWFGNHLATTKRVNVGQVVTVFGSCLSVASSLQQILPAIPDLIKGKFSSHFIKTLCESHDPIEAAKRSAAKIKSISFERGFRFDNVSFAYPSRDENLFSLINVSVFIPFGELVHIIGPSGSGKSTFISLLLRYFSPTYGNIYLDDFPLEEIDEHVLGSTITLVCQQPVIFDMTIRENIIMRNENASESDFEEVCRLALVDEFALTFDQSYDTPCKEASLSGGQQQRIALARALLRDTEILILDEPTSALDPITKNLVMDAIRAHRKGKTTLVITHDMSQINNDELVLVIDKGHLIQRCARKELVLFEDFENNVSIDEKVLKEEADNPFILPNEESLLEKYWINYNESFSQLSRESLFTSLESPFTDIESPTIVSRRKIVEQRKLRMEKESFQETNVDQTFHLFDDKEHACSLTLIFKSIWKVKKLRWFFLLGLLTSLIQGASVPIFAYVISKCLNLFMQIDPSIGVAFWSSMVLVVAAGSGASYFFSHYIFSISAKIWCDHYRLLAVKVLFTQDQAWFDQIENYPLVLSKILVNNISDMRNMISSLIEEVFIAFTMAIIGIAWSFATGWRLAAVLVAVSPILCLTSRMFSYIYVSTERMCQDVVISTTSILHKTIVNLDTIKGYSVLSFFRENHKNSLRKSWEAFKRRAFWTSLGFAINNSLLYFVRALLFYCSSIFISKEFYTVEQMVQVLSLATFTLLMASTCIMSLPNVSASRIATSRVLKLSSLKPGNLHKSGYLKFPLVGKIEFDGVSFAYPDSERNHLALNNVSLSIEAREKVAIVGISGSGKSTLVELLRKTYPSEDIYIDGYPLTNIDTNWLLKKVAIVDQKPHLLGSTILESLLYGVDRDINSVMDALDKTYMTEVIQNLPNGLDTPLLEFSKNFSGGQIQRLAFARALLRNPRLLILDECTSALDSKSSLLLEKTIQNLSCTVLIITHQPSLMKLADRIIVMDSGIVKESGSFDELMNRHTHFWKLIHRGEWIE
What is the function of this protein?
Required in S. pombe M (minus) cells for production of M-factor pheromone.  Involved in the transport of the farnesyl-derivation of the M-factor pheromone.
What are the official names of this protein?
Mating factor M secretion protein mam1, Multiple drug resistance protein homolog, P-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CAH_BACSU
Sequence: MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDLQPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEMVNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRALEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVALEQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPSTVFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG
What is the function of this protein?
Esterase that removed acetyl groups from a number of O-acetylated small substrates, such as acetylated xylose, short xylooligosaccharides and cephalosporin C.  Has no activity towards polymeric acetylated xylan.  Cannot cleave amide linkages.
What are the official names of this protein?
Cephalosporin-C deacetylase, Acetylxylan esterase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate esterase 7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROF3_CAEEL
Sequence: MSWSDIINNNLIGSGNVSKAAILGFDGAVWAKSDNFNISVEEAVAAGKAFTSLDALLGTGLRLEGQKFLVLNADNDRIIGKQGGSGFFIYKTIQAVIISIYEKGLQPEMCSKTTGALADYFRSIKY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG.  Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
What are the official names of this protein?
Profilin-3.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PAN3_CAEEL
Sequence: MQPGEGYHYDSGPNNAVHPHQLPAGSRLNQYLANNNRQGPSFGPGTPINVNAPVFVPKHQQPQPAQVAAPPPMVNQFAQLSIHDVPHQMIPFGQINGPPTFGPGQHMNHRASHHHQSPQMAQQPPTLQQSAYDRYQLENRGGTTYFYTEPTEAGPDDEQYTEAEAPDGSILVNTPGAFGYNAPLPISHMARFRGKANANLQTQFISPEIRMELINRQLAYDTKADSAIIGDIPHSVEHFSNLVPLEIAGIQSQTTYKAFSCRDGNYYCLRRIHGNRIQHPGKQTHLVEQWKKLVHGNVVPLREVLINCRAFDDSSLIFAYDYYPLAGTLMEKHFDTKSGTFFDPNNGFRISSPMNVSMPISGTGAHETLIWSYIIQIAAALRAIHSSGLACRTLDLNKIITYGNKIMISFCGIQDVLDPDPTTIQQQQNEDLNMFGNLIVALATGRANGWRKDLYQQLKKFIEDTYSMDLRNVIGFLHNNSTRKTINEIMPMIGGRFFTVMENMQAKTDVLEAELSREMENGRLFRLVAKMNTVLERVEHGTDDAWSETGDRFMLKLFRDYVFHQVTDQGKAWLDMAHIVQCLNKLDCGSQEKIEMVSRSGDTQIIIDYATLKRCLDKSFRDLLGTNMMLHR
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP).  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.  Within the PAN complex, may positively regulate fertility (PubMed:23843623).
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: RS14_STUS1
Sequence: MAKQSMKNRELKRQRTVAKFAQKRAALKAIIASPESTPEARWEAQVALQKQPRDASASRLRNRCRLTGRPHGVYRKFGLARNMLRQAAMRGDVPGLVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ACVR1_BOVIN
Sequence: MVDGVMILPVLVMIAFPFPSMEDEKPKVNPKLYMCVCEGLSCGDEAHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
What is the function of this protein?
Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation.  As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B.  Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain.  In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal.  In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.  Besides canonical SMAD signaling, can activate non-canonical signaling pathways.
What are the official names of this protein?
Activin receptor type-1, Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PURQ_ENTFA
Sequence: MKLAVIVFPGSNCDADLLWAVKEVMGIDAEFVRHDATSLAKFDGVLLPGGFSYGDYLRCGAIARFSPIINEVIRFATEGKMVFGTCNGFQILTEIGLLPGTLLRNDSLRFICKSVPLKVNTHTKFTSEYPENVSIHLPVAHGEGNYYCDEKTLKELKEKNQIVFTYQEKVNGSLANIAGICNEQGNVLGMMPHPERAMEELLGSTDGRSFFASIIKNFGKELSQ
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNQ3_BOVIN
Sequence: MGLKARRPAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFREYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLDPAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGSNNKERFRTAFRMKAYAFWQSSEDAGTGDPTAEDRGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQRGAAFTYPSQQSPRNEPYVARPSTSETEDQSMMGKFVKVERQVHDMGKKLDFLVDMHLQHMERLQVHVAGFSPSKGASSPAEAEQKEDRRDADLKTIICNYSETGAPDAPYSFHQVPVDKVGPYGFFAHDPVNLPLGGPSSGKGHATPYAERPTVLPILTLLDSRGSYRSQVELHGPCSDRVSPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYAFGPSGGSSWMREKRYLAEGETDTDTEPFTPSGSLPLSSTGDGISDSIWTPSGKPT
What is the function of this protein?
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.  Therefore, it is important in the regulation of neuronal excitability.  KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+).  Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation.
What are the official names of this protein?
Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.