PharMolix/UniProtQA huggingface dataset:
Protein: KIF2C_CRIGR
Sequence: MESLPARLFPGLSIKIQRSNGLIHSANISTVNVEKSCVSVEWIEGGNTKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTVPKQKRRSVNSKIPAPKEGLRSRSTRMSTVPEVRIATQENEMEVELPVATNSRKQFSVATGLPRPSCPAMTELPLSMVSEEAEEQVHPTRSTSSANPARRKSCIVKEMEKMKNKREEKRAQNSEIRIKRAQEYDSSFPNWEFARMIKEFRVTIECHPLTLTDPTEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLFVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNTSKGIYAMASRDVFLLKSQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSKQQVQVVGLQEYLVNCADDVIKMLNMGSACRTSGQTFANSNSSRSHACFQILLRAKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGLSGEQPIQMETEEMEASSNGTSLAVNFKEEEELSSQMSSFNEAMSQIRELEERAMEELREIIQQGPGWLELSEMTDQPDYDLETFVNKAESALTQQTKHFSALREVIKALRVAMQLEEQASKQMNSKKRHQ
What is the function of this protein?
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (By similarity).  Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:14960279).  Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity).
What are the official names of this protein?
Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, through interaction with MTUS2/TIP150 and MAPRE1 (PubMed:19543227). Association with microtubule plus ends is also mediated by interaction with KIF18B (By similarity). Centromeric localization requires the presence of BUB1 and SGO2 (By similarity).
Protein: ASA1_YARLI
Sequence: MDLSGAPVPVALLRGHTHPVTSLRFYNAFLVSGDESGWVFWWSLVTRRPLAIWKAHHEAILSLVWMDETHLLTQGRDDKLYVWRLELDAQGKSGLSVKPPSSLVADDPTDYPKPWLTYSLTVNSLNFCQVAWVNGLLAKPDLDSSDKVELLEWTDGAFRVVWNDIYPRLNGIKTGIVMDLNIMNKKLIVGYEGGAVAVFDISDRNRYTPVLNYYVVSHVQPVLSVRAHPTKKEFVSSSADSLIVKHPIKDQVVPEEEMEEPEPAKNSERPPSPKIVEVEDSPELEPPKNVVRGFDVPGLELEEGIEVKEEEKPESKPLDAVNVRHSGLSSLQLDSDGDLIMTAGWDGKVRLFTYDDISKVSVFHEREGVGCVAFSTPTTSDTANPRLAKALTTRWIAVGGKDGKIELYTIQQGNEKTLGEGRSKYIRH
What is the function of this protein?
Component of the ASTRA complex involved in chromatin remodeling.
What are the official names of this protein?
ASTRA-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ASA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_SALAR
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PDXA_THISH
Sequence: MTTTPRIAITPGEPAGIGPDLVVAVAQVPCAAQRVVLSDPALLRERARLLGLPLEIRPFDPQTPAAPDPAGCLTVMAHALNAPVRPGHLDTANARHVLATLESAVAGCLDGRFDALVTGPVHKGIINDAGIPFTGHTEFLAERSGAPTPVMLLAAGALRVALATTHLPLRAVADAITPAGLEHVLRVLNQDLKTKFAISEPRILVCGLNPHAGEGGHLGREEIEVIGPVLERLRTQGLHLIGPLPADTLFTPRHLEHADAILAMYHDQGLPVLKHAGFGRAVNITLGLPLIRTSVDHGTALELAGSGRAEAGSFMEAERLAIEMARSAHGL
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBN_CITK8
Sequence: MELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQHQMLNTAFNPGKLDRIFISHLHGDHLFGLPGLLCSRSMAGNAQPLTIYGPKGIREFTETALRLSGSWTDYPLEIVEITAGEILNDGLRKVTAFALEHPLECYGYRIEEHDKPGALDASALKAAGVKPGPLFQDLKAGKTVTLNDGRVINGADFLAPATPGKSVAIFGDTAPCASAITLAKGVDVMVHEATLDTSMEEKANSRGHSSTRQAAQLAHNAEVGQLIITHVSSRYDDRGCQRLLAECQAIFPATALAHDFAVFTV
What is the function of this protein?
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
What are the official names of this protein?
Ribonuclease BN, RNase BN, Ribonuclease Z homolog, RNase Z homolog.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family. RNase BN subfamily.
Protein: MCRB_METFE
Sequence: MPKYEDKVDLYDDRGNLVEEQVPIEALSPLRNTAIKKIIHDIKRTVAVNLEGIENALRSAKVGGSGCHIPGRELDVDVIDNAEAIAEKAKEMIQVEEGDDTVVELLHDGKRALVKVPSSRLESAAEYSVAPLVTASAFIQSIIDVCDISIYDANMVKAAVLGRYPQSVEYVGGNIATMLDIPQKLEGPGYALRNILVNHIVAATLKNTLQAVALSSILEHTAMFEMGDAVGKFERLHLLGLAYQGLNADNLLYDLVKANGKDGTVGSVVEDVVERAKEDGVIKVEKELNGYKVYGTDDLALWNAYAAAGLVAATIVNQGAARAAQGVSSTILYDNDIIEFERGLPGVDFGRAEGTAVGFSFFSHSIYGGGGPGIFNGNHIVTRHSKGFAIPCVAAAMALDAGTQMFSPELTSGLIKDVFSKVDEFREPLKYVVELQPK
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase subunit beta, Coenzyme-B sulfoethylthiotransferase beta.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPH_NICSY
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GLTX_GLYTI
Sequence: GGCYQSCEPHTLKCGSVSFEAKCKSGWSCYPVTDNIASNACDRFKSCQDRWATVKETDAPCTSCVPGFQLTSRGYCSQDLNECNRNNGGCTNGKCINTEGSYHCDCDRGYLATSSRTKCEGVECEPLTLANGKVQSNKGSWIFGSRALFTCDDQARSVLDGPSYITCNLDAAGLTASWSGTSPTCQNDDEHDRFAEVFHLRFHGKKLDGVSLVTGLSPRSTAYRCHKDSTCQGIMTRAEEFEVSATGLTVYDGGVLTKTLGQSRADGDALTDDASMDIYTKVDVSSAAASSYQDVLDAMVGTSLGCYTTSSMASWEDYTLDDGRATTCNQICLQAGYDYFGIQASDKCWCGQKPPVEKVGDGECSTVCVNQANILCGSATTANIYQVYRDRSLGFCYTGNLGTETVPSAKTKDECVTVCRGQGYYTANIRNSGECFCDNSLPGGPRVDPTKCDEDGSGHSTVYMTNPAYFMSNDQGAQINPMTTRMYDDTGSVTGMTTGLFQRLPGLRIFTSDRLVLYSAEEVQFHDVQNDYADTCGEIKRIDGESDRSGDLILHFFHFRLSQLAKHTSDRASRVYIYAQKVVIDCDIQVQFSLMIRATKIVVSTGKVFKILVGSESSQIEMDVDDVKNNGPPRNLQQMKDSLQCARMLAQSWDDTEKQKLAFNILHEMTSPTAGNEAQRSVQTMASALKLQLEGMFKNDIHHVPSYSAAYFTYLMKADSDIVNAYAARLNALEVITTSRDDFLNYTQELEKIHQDTSIAQAKKRFDETMKLYKKEDLVYTKLQAAYDTALTNLRGVIPTFRKSIEAQEDHLRFKALLSFLELGVAAMDPAAVASVSKGFYDDVTDIAASSIWGIDQVVTNIDSFTDVMTNNLNEMMSEVKPYDGTKYAYEIEKVANMHVFVEEWRNFQVEVNNILGDDTVSALGGAGDYGRNLVKLTNIGMALTNAMINRAEKTRDAAQKRTTWDLLVEQGRRTTEVIKGFKAANSERAAANSVVAEQIRDITSEINGDLANFCEAYFFEKLEPCPKSTQPRFGGDLLSVQLSISRAEREAASLGLDGSPVSREVTITNTDASEDCIDVTQCPVTVFKRDRAFSYEVPIDNFDLSDWDKYRVKEIEVKAIGATPDRTETDLKLFVRSSGSFSGKSGGTHYNFLTDDFFCVYEYDINSPIDAPPESASGRCTVYARGSKKDMTRYATPYAAWMIEVD
What is the function of this protein?
Potent venom presynaptic neurotoxin that promotes a long-lasting increase in spontaneous neurotransmitter release at the peripheral and central synapses by selective activation of Cav2. 2/CACNA1B (N-type) channels (PubMed:12485994).  In addition, it drastically enhances synaptic-vesicle recycling, an effect that is prevented by the Cav2. 2-specific inhibitor conotoxin-MVIIA (PubMed:20215402).  It activates Cav2. 2/CACNA1B by shifting the current-voltage relationship of channels towards more hyperpolarized potentiels in a reversible manner (PubMed:12485994).  May have two separate sites of action on Cav2. 2: one high affinity linked to changes in gating properties, and a second low affinity that results in block of current activity (PubMed:12485994).
What are the official names of this protein?
Glycerotoxin paralog 1, GLTx paralog 1.
Protein: PPE21_MYCTO
Sequence: MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAATVHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVALSLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANTGSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPGSGNTGTLNWGSGNIGSYNLGGGNLGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSGNLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNIGFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNSATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISGFVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH
What are the official names of this protein?
Uncharacterized PPE family protein PPE21.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MAL2_BOVIN
Sequence: MSAGGAPVPPPPNPAMSFPAPRVTLPAGPDILRTYSGAFVCLEIVFGGLVWILVASSNVPLPLLQGWVMFVSVTAFVCSLLFLGVFLSGVVTQINANWNFLDFAYHFTVFVFYFGAFLLEAATTSLHDLRCNRTMTVQPLLSDNQYNINVAATIFAFVTTACYGCSLGLALRRWRP
What is the function of this protein?
Member of the machinery of polarized transport.  Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity).
What are the official names of this protein?
Protein MAL2.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface (By similarity).
Protein: ULAE_MYCPN
Sequence: MLVIHFKPYNNLKMSFTSTENKHLLGVYEKAINNKFAWKDKIAIAKQASFDFIELSIDESDARLQRLDWSDTEINQLHNELQAQTFCLNSMCLSAHRRFPLGSKNKTTVQQGLTIFEKACVLARKLGIRIIQLAAYDVYYEPHDTETERNFITNMRKVAELAQKYAVTIAFEVMDTPFAGTIVRCLNLIKRIGKANILLYPDIGNLSQFSTAVFDEIALGQDKIVGFHFKDTLPKQFKEVPFGTGTAQFEAALKAIHQYVPTVPILIEMWSKNDPAESTVQNVAQLKQAKQFYEQQWDLALKRVK
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization (By similarity).
What are the official names of this protein?
Probable L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: ATG4_ASPCL
Sequence: MNSVDIGRYKRIINYLWDPEPRNDLPDEPIWCLGIRYPPNHRGWKTQDQDGSAQGQYEQKTIPTEKANEHQWPEEFLDDVESRIWITYRSNFTPIPKPPNQEANPAMTLTVHLRSQLMDSQGFTSDTGWGCMIRSGQSLLANAMLILLLGRDWRRGTEAGKEAQLLHQFADHPEAPFSIHRFVQHGAEFCNKYPGEWFGPSATARCIQALVAQQGSSELRVYITDDTADIYEDKFARIAQAEHGDFIPTLILVGTRLGIDHVTPAYWDALKEALQLPQSVGIAGGRPSASHYFIGVHGQYLFYLDPHHTRPASLHQDVNDTLTHEEVNTYHTRRLRRIHIKDMDPSMLIGFIIRSREDWTDWKTRILSGRGNSIVHILSEDTANHQARKEAIDEVEALDD
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease atg4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: CID13_SCHPO
Sequence: MDNANCVGGCKFETRSFQYRRRIPYSLGADPLPPVHPLSLKNLVDIDTDLISSQLYELYDSIILNDSGLERRYAFVQKLEQILKKEFPYKNIKTSLFGSTQSLLASNASDIDLCIITDPPQCAPTTCEVSAAFARNGLKKVVCISTAKVPIVKVWDSELQLSCDCNINKTISTLNTRLMRSYVLCDPRVRPLIVMIKYWAKRRCLNDAAEGGTLTSYTISCMVINFLQKRDPPILPSLQMLPHLQDSSTMTDGLDVSFFDDPDLVHGFGDKNEESLGILFVEFFRFFGYLFDYEHFVLSIRHGTFLSKRAKGWQFQLNNFLCVEEPFHTSRNLANTADEITMKGIQLEFRRVFRLLAYNCNVDDACSQFTFPSLTDTSFMDDYVNELQLEIVPGFSHGRDSSDTSCTESPPEPSHFAWAFDPYNATASPYYNQNINSSIDYSSIYSNDVPAIPPNVPYTFVDPYTYACYINNNSYLPPSYMDFYTWYNSPYPKSSHHFDERHGGDRHEKNLSNSRRYSRNKFHKKKQSSGPFQYYPDAFSFTPTDNNSPPSNSSSSEVVSPVSLHSEPVLSTVQAFKS
What is the function of this protein?
Polymerase that creates the 3' poly(A) tail of suc22 mRNA.
What are the official names of this protein?
Poly(A) RNA polymerase cid13, PAP, Caffeine-induced death protein 13, Polynucleotide adenylyltransferase cid13.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEIG1_XENLA
Sequence: MSASEAKPKSMTRAKQWSDEIENLYRFQTAGYRDEVEYRHVKQVEMVDRWPETGFVKKLQRKDNTFYYYNKKRECEEKEVNKVKVYAY
What is the function of this protein?
Essential for spermiogenesis.
What are the official names of this protein?
Meiosis expressed gene 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the MEIG1 family.
Protein: NUP40_SCHPO
Sequence: MSFGGSGSITNRSTLKPLSVDDLRSPSPQKEYRGFRTSVSNIPQEKKFVPSHLSHFGSSQQRRFAPEVSSPLAEPYESSSSFRLSLSSPPSSKFGGPSFGTPKPFLHTNRLGTGSLIEDAPPTQSIYDFSSSRQINALNVGQSSSPFSPVSEKVYDPSFTMSGAPQDSNTSVIVFGFPPELTNQVIAEFSRFGTIISENSLTASSAGFTPSKGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSPAEAKEHVPKTLRNSNKDLEMTDASSSETSMSIPVHADAHFQSQSGLGKKVIVQHKNDIFKSSQKHQPRNWLFHYLFGFGSTEPIDEEEKSKTASDNTSLQTSLFGKIVQVVLHTLFGF
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
What are the official names of this protein?
Nucleoporin nup40, Nuclear pore protein nup40.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
Protein: OMPB_RICTY
Sequence: MAQKPNFLKKIISAGLVTASTATIVAGFSGVAMGAVMQYNRTTNAAATTVDGAGFDQTGAGVNLPVATNSVITANSNNAITFNTPNGNLNSLFLDTANTLAVTINENTTLGFVTNVTKQGNFFNFTIGAGKSLTITGHGITAQQAATTKSAQNVVSKVNAGAAINDNDLSGVGSIDFTAAPSVLEFNLINPTTQEAPLTLGDNAKIVNGANGILNITNGFVKVSDKTFAGIKTINIGDNQGLMFNTTPDAANALNLQGGGNTINFNGRDGTGKLVLVSKNGNATEFNVTGSLGGNLKGVIEFDTTAAAGKLIANGGAANAVIGTDNGAGRAAGFIVSVDNGNAATISGQVYAKDIVIQSANAGGQVTFEHLVDVGLGGKTNFKTADSKVIITENASFGSTDFGNLAVQIVVPNNKILTGNFIGDAKNNGNTAGVITFNANGTLVSGNTDPNIVVTNIKAIEVEGAGIVQLSGIHGAELRLGNAGSIFKLADGTVINGPVNQNPLVNNNALAAGSIQLDGSAIITGDIGNGAVNAALQDITLANDASKILTLSGANIIGANAGGAIHFQANGGTIQLTSTQNNILVDFDLDVTTDQTGVVDASSLTNNQTLTINGSIGTIGANTKTLGRFNVGSSKTILNAGDVAINELVMENDGSVHLTHNTYLITKTINAANQGKIIVAADPINTDTALADGTNLGSAESPLSNIHFATKAANGDSILHIGKGVNLYANNITTTDANVGSLHFRSGGTSIVSGTVGGQQGLKLNNLILDNGTTVKFLGDITFNGGTKIEGKSILQISSNYITDHIESADNTGTLEFVNTDPITVTLNKQGAYFGVLKQVMVSGPGNIAFNEIGNGVAHAIAVDSISFENASLGASLFLLSGTPLDVLTIKSTVGNGTVDNFNAPILVVSGIDSMINNGQVIGDQKNIIALSLGSDNSITVNSNTLYAGIRTTKTNQGTVTLSGGIPNNPGTIYGLGLENGDPKLKQVTFTTDYNNLGSIIATNVTINDDVTLTTGGIAGTDFDGKITLGSINGNANVKFVDRTFSHPTSMIVSTKANQGTVTYLGNALVGNIGSSDIPVASVRFTGNDSGVGLQGNIHSQNIDFGTYNLTILNSDVILGGGTTAINGEIDLLTNNLIFANGTSTWGNNTSLSTTLNVSNGNVGQIVIAEGAQVNATTTGTTTIKIQDNANANFSGTQTYTLIQGGARFNGTLGAPNFDVTGNNIFVKYELIRDANQDYVLTRTNDVLNVVTTAVGNSAIANAPGVHQNIAICLESTDTAAYNNMLLAKDSSDVATFIGAIATDTGAAVATVNLNDTQKTQDLLGNRLGALRYLSNSETADVGGSETGAVSSGDEAIDQVSYGVWAKPFYNIAEQDKKGGLAGYKAKTAGVVVGLDTLANDNLMIGAAIGITKTDIKHQDYKKGDKTDIKGLSFSLYGAQQLVKNFFAQGSAIFTLNKVKSKSQRYFFDANGKMNKQIAAGNYDNITFGGNLMFGYDYNALQGVLVTPMAGLSYLKSSNENYKETGTTVANKRIHSKFSDRIDLIVGAKVTGSAMNINDIVIYPEIHSFVVHKVNGKLSKAQSMLDGQTAPFISQPDRTAKTSYNIGLSANIRSDAKMEYGIGYDFNAASKYTAHQGTLKVRINF
What is the function of this protein?
The 32 kDa beta peptide may serve as a membrane anchor.
What are the official names of this protein?
Outer membrane protein B, 168 kDa surface-layer protein, Cell surface antigen 5, Sca5, Surface protein antigen, rOmp B, rOmpB.
What is the protein family that this protein belongs to?
Belongs to the rickettsiae OmpA/OmpB family.
What are the subcellular locations of this protein?
[Outer membrane protein B]: Periplasm. SUBCELLULAR LOCATION: [120 kDa surface-exposed protein]: Secreted. Cell surface. Note=Surface exposed. This bacterium is covered by a S-layer with hexagonal symmetry. SUBCELLULAR LOCATION: [32 kDa beta peptide]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Protein: RUVB_CAUVN
Sequence: MTRVISGEPQHGDLAPADRALRPQTLAEFVGQEQAKGNLRVFIEAAKGRGEALDHVLLFGPPGLGKTTLAQIVARELGVNFRATSGPVLNKPGDLAAILTNLEANDVLFIDEIHRLSSNVEEILYPAMEDHVLDLVIGEGPSARSIRIDLAPFTLVAATTRAGMLATPLRDRFGIPIRLEFYTPAELRHVLQHAARKMGAPLTDDGADEIAKRARGTPRVAGRLLRRVRDFATADGADRIDRKAAAMALARLEVDESGLDSLDRRYLRAMIENYGGGPVGVETIAYAIAEARDAVEDVIEPYLMQQGFIQRTPRGRMACGKAYLHLGLTPPAAPPGQAQGALFDEG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NUOH_RICBR
Sequence: MIELFFEYIFPLIIIALKVVAITIPLILCVAYLTYAERRVIGLMQLRRGPNVVGPFGLLQPIADAVKLLFKEPIIPTNADKILFVLAPMITFILSLIGWAVIPFAKGVVLADINVGVLYILAISSLSVYGIIIAGWASNSKYAFLGAIRSSAQMISYEVSMGLVIITVLLTTGTLNLSQIVEAQRTMPWWIDLMLMPMGVVFFISVLAETNRLPFDLPEAESELVAGYNVEYSSMGFALFFLGEYANMILVSAMTTTFFLGGYLPPFNISWLDCIPGFFWFVFKVGFLLFCFLWIRATLPRYRYDQLMRLGWKVFLPLTLFWVVLVSSVLIYTDHLPNV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NCAP_IBVM
Sequence: MASGKATGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKANKLNIPPPKFEGSGVPDNENLKSSQQHGYWRRQATFKPGKGGRKPVPDAWYFYYTGTGPAANLNWGDSQDGIVWVAGKGADTKFRSNQGTRDSDKFDQYPLRFSDGGPDGNFRWDFIPLNGGRSGRSTAASSAASSRAPSREVSRGRRSGSEDDLIARAARIIQDQQKKGSRITKAKADEMAHRRYCKRTIPPNYKVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVPSSHACLFGSRVTPKLQPDGLHLKFEFTTVVPRDDPQFDNYVKICDQCVDGVGTRPKDDEPRPKSRSSSRPATRGNSPAPRQQRPKKEKKPKKHDDEVDKALTSDEERNNAQLEFYDEPKVINWGDAALGENEL
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the gammacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: RL19_PARP8
Sequence: MNLIAKLEQEEIERALAGKTIPEFAPGDTVIVSVNVVEGNRKRVQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRAAQA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.