PharMolix/UniProtQA huggingface dataset:
Protein: INO1_WHEAT
Sequence: MFIESFKVESPNVKYTENEIHSVYDYETTEVVHENRNGTYQWVVKPKTVKYDFKTDTRVPKLGVMLVGWGGNNGSTLTAGVIANKEGISWATKDKVQQANYFGSLTQASSIRVGSYNGEEIYAPFKSLLPMVNPDDVVFGGWDISDMNLADAMARARVLDIDLQKQLRPYMEHMVPLPGIYDPDFIAANQGSRANSVIKGTKKEQVDQIIKDMREFKEKNKVDKLVVLWTANTERYSDVVVGLNDTMENLLASVEKNESEISPSTLYAIACVLEGIPFINGSPQNTFVPGLIELAISKNCLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVASNGILFEPGEHPDHVVVIKYVPYVGDSKRAMDEYTSEIFMGGKNTIVMHNTCEDSLLAAPIILDLVLLAELSTRIQFKAEGEGKFHSFHPVATILSYLTKAPLVPAGTPVVNALSKQRAMLENILRACVGLAPENNMILEYK
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_MYCSS
Sequence: MSAPTTAIDALLAEHADLERQLADPALHADAGKARKAGRRFAQLAPIVATYRKLEAARGDLEAARELGADDASFAAEVPELEATVDQLETQLSDLLAPRDPHDADDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWSVTILDETTSDLGGYKDATLSIRSKGDSADGVWSRLKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVEQVQIDESDLRIDVYRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKARAMQVLAARLQSLAEEQASADASADRASQIRTVDRSERIRTYNFPENRIADHRINFKAHNLDQVLDGDLDPLFDALAAADKQARLQSS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_ESOLU
Sequence: MVSSQEKMASISDIIQKDEDSGSEKTESQDKEHPRVLIPELCRLFYKLGWVTGTGGGISLRHGDQIYIAPSGVQKERLQPEDMFVCDVEERDICVPPAWKNLKKGQCTPLFMNAYTMRAAQAVIHTHSKAAVMATLFYPGKEFRITHQEMIKGIRKCTSGTNYRYDETLVVPIIENTPEEQDLKERMALAMEQYPESCAVLVRRHGVYVWGESWEKAKTMCECYDYLFDIAVKMKQCGLDPSAQPVEENLYYYVQQA
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).  Functions in the methionine salvage pathway.  May play a role in apoptosis.
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase, APAF1-interacting protein homolog.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABD12_RAT
Sequence: MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
What is the function of this protein?
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity).  Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity).  Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal.  Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways.  Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).
What are the official names of this protein?
Lysophosphatidylserine lipase ABHD12, 2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12.
What is the protein family that this protein belongs to?
Belongs to the serine esterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: B3A2_HORSE
Sequence: MSSAPRRPASGADSFRTPEPEILGPATAGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDTRRRKTPQGPGRKSRRRPGASPTGETPTIEEGEEDEDEASEAEGARAPTQPSPASTPSSVQFFLQEDDGADRKAERTSPSPPPPLPHQEAAPRATKGAQTGALVEEVMAVAGGTAGGDDGGASGRPLTKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSVQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRADVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLIGGVPETRLEVERERELSPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAVEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNDLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSVSNSSEADSGDNATWAGTRVTLGLGNGSSAGPAGQGRPRGQPNTALLSLVLMAGTFFIAFFLRKFKNGRFFPGRVRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSSFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDEREGVDEYNEMPMPV
What is the function of this protein?
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (By similarity).  Plays an important role in osteoclast differentiation and function (By similarity).  Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity).  Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell response (By similarity).
What are the official names of this protein?
Anion exchange protein 2, AE 2, Anion exchanger 2, Non-erythroid band 3-like protein, Solute carrier family 4 member 2.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NDT80_YEAST
Sequence: MNEMENTDPVLQDDLVSKYERELSTEQEEDTPVILTQLNEDGTTSNYFDKRKLKIAPRSTLQFKVGPPFELVRDYCPVVESHTGRTLDLRIIPRIDRGFDHIDEEWVGYKRNYFTLVSTFETANCDLDTFLKSSFDLLVEDSSVESRLRVQYFAIKIKAKNDDDDTEINLVQHTAKRDKGPQFCPSVCPLVPSPLPKHQIIREASNVRNITKMKKYDSTFYLHRDHVNYEEYGVDSLLFSYPEDSIQKVARYERVQFASSISVKKPSQQNKHFSLHVILGAVVDPDTFHGENPGIPYDELALKNGSKGMFVYLQEMKTPPLIIRGRSPSNYASSQRITVRTPSSVNSSQNSTKRKMPSMAQPLNESCLNARPSKRRSKVALGAPNSGASISPIKSRQSTPMEASKENEDPFFRPNKRVETLEHIQNKLGALKNQCPDSSLKYPSSSSRGMEGCLEKEDLVYSSSFSVNMKQIELKPARSFEHENIFKVGSLAFKKINELPHENYDITIEKKSMEQNYLRPEIGSRSECKTSYGNELSLSNISFSILPNSAENFHLETALFPATEEDVPRTFSRILETGSFQNYYQKMDAENADRVYSKGVKLIASGTLPSGIFNREELFEEDSFYKY
What is the function of this protein?
Transcription factor required for successful completion of meiosis and spore formation.  Gets activated after completion of meiotic recombination at the end of prophase I.  Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation.  Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.
What are the official names of this protein?
Meiosis-specific transcription factor NDT80.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOD5_MOUSE
Sequence: MAAAAAARAVPVSSGFRGLRRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQKMCQHHMISFVDPLVTSYTVVDFRNKATALIEDIFARDKIPIVVGGTNYYIESLLWKVLITTKPQEMGTGKVVDRKVELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLRFPNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRGFHRRYNLKNISENSQDYQHGIFQSIGFKEFHEYLTTEGKCTPETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPSVPPVYGLEVSDVSKWEESVLEPALNIVQSFIQGHKPTAMPVKMAYNESENKRSYHMCDLCDRIIIGDREWAAHLKSKSHLHQLKKRRRLDLDAVSATGSQSNSPDCDPERIEGESSGQHNQELKASV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:23289710).  Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (By similarity).  TRIT1 is therefore required for selenoprotein expression (PubMed:23289710).
What are the official names of this protein?
tRNA dimethylallyltransferase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, tRNA isopentenyltransferase, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
What are the subcellular locations of this protein?
[Isoform 1]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Protein: S2538_YEAS1
Sequence: MTEQATKPRNSSHLIGGFFGGLTSAVALQPLDLLKTRIQQDKKATLWKNLKEIDSPLQLWRGTLPSALRTSIGSALYLSCLNLMRSSLAKRRNAVPSLTNDSNIVYNKSSSLPRLTMYENLLTGAFARGLVGYITMPITVIKVRYESTLYNYSSLKEAITHIYTKEGLFGFFRGFGATCLRDAPYAGLYVLLYEKSKQLLPMVLPSRFIHYNPEGGFTTYTSTTVNTTSAVLSASLATTVTAPFDTIKTRMQLEPSKFTNSFNTFTSIVKNENVLKLFSGLSMRLARKALSAGIAWGIYEELVKRFM
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DERL3_HUMAN
Sequence: MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
What is the function of this protein?
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins.  May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome.  May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976).  May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).
What are the official names of this protein?
Derlin-3, Degradation in endoplasmic reticulum protein 3, DERtrin-3, Der1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SHUT_ADEG1
Sequence: MADKITREEKTIATLDLVLRVVVDAGNWDVFSKRLVRYTREQYGIELPEDIGDLPDTSEVSKVLLSHLGEDKAVLSAYRIAELTQPSEMDRAKVTEGGLAVLNASRDESEAQNPSNPEPESIESDAVEDLGVAAESDPSDDEPDPEPEYDHREADHDSDADSGYYSADGGRPGTPVDEEPQDDSPSSEETASTVIEEAQTSASNDSHDDDTHRDDGSASEEDLERDALVAPADPFPNLRKCFERQAMMLTGALKDAADTADPPETLSVDSVQRQLERFVFNPDRRVPAEHLEVRYNFYPPFLTPKAIASYHIFAVTASIPLSCKANRSGSDLLAKAKESTFFKRLPKWRLGIEIDDGLGTEVTAVTELEEAKMVPLKDDVSRLQWAKMRGEHIRFFSYPSLHMPPKISRMLMETLLQPFADENQKAEEALPCLSDEEVLAIVDPTGRLHGEDALKAVEKRRAAVTMAVRYTATLELMERVFREPSMVKKMQEVLHHTFHHGFVALVRETAKVNLSNYATFHGLTYNNPLNNCIMSKLLEGADKEDYVVDSIYLFLVLTWQTAMGMWQQAIDDMTIQMYTEVFTKNKYRLYSLPNPTAIGKAIVDILMDYDRLTEEMRKALPNFTCQSQITAFRHFLLERSNIPAVAAPFMPSDFVPLAYKQSPPLLWDQVYLLQLAFYLTKHGGYLWEAPEEEANNPSNRTYCPCNLCSPHRMPGHNAALHNEILAIGTFEIRSPDGKTFKLTPELWTNAYLDKFDAEDFHPFTVFHYPENASRFASTLKACVTQSPEILSLIRQIQESREEFLLTKGKGVYKDPNTGETISRQPRDTARAQHAGDGQALPAPGAYTTGGNRAETAPAGAVRLAPDYQDGQFPIAKVGPHYHGPKNVRREDQGYRGGPGGVRGEREVVLSRRAGGRRFGRRNTRQSGYNERANRYFGRGGGGSVRGQQGEHPTTSPSASEPPAPSRILARGTPPSPERRDRQEE
What is the function of this protein?
Protein that inhibits host translation while promoting late viral translation by ribosome shunting.  Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation.  Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell.  During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
What are the official names of this protein?
Shutoff protein, 100 kDa protein, p100K, 100K-chaperone protein, L4-100K, Shutoff protein 100K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae shutoff protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: METK_PSEPG
Sequence: MSEYSLFTSESVSEGHPDKIADQISDAVLDAIIAQDKYARVACETLVKTGVAIIAGEVTTSAWVDLEDLVRKVIIDIGYNSSDVGFDGATCAVMNIIGKQSVDIAQGVDRSKPEDQGAGDQGLMFGYASNETEVLMPAPICFSHRLVERQAEARKSGLLPWLRPDAKSQVTCRYENGKVVGIDAVVLSTQHNPEVSQKDLQEAVMELIVKHTLPAELLHKGTQYHINPTGNFIIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISINTFGTGKVSDDKIIQLVRECFDLRPYAITTMLDLLHPMYQETAAYGHFGRTPQQKTVGDDTFTTFTWERTDRAQSLRDAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIAO_ECOLI
Sequence: MKLRSVTYALFIAGLAAFSTSSLAAQSLRFGYETSQTDSQHIAAKKFNDLLQERTKGELKLKLFPDSTLGNAQAMISGVRGGTIDMEMSGSNNFAGLSPVMNLLDVPFLFRDTAHAHKTLDGKVGDDLKASLEGKGLKVLAYWENGWRDVTNSRAPVKTPADLKGLKIRTNNSPMNIAAFKVFGANPIPMPFAEVYTGLETRTIDAQEHPINVVWSAKFFEVQKFLSLTHHAYSPLLVVINKAKFDGLSPEFQQALVSSAQEAGNYQRKLVAEDQQKIIDGMKEAGVEVITDLDRKAFSDALGNQVRDMFVKDVPQGADLLKAVDEVQ
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate.  This protein specifically binds 2,3-diketo-L-gulonate.  Is not able to bind either L-ascorbate or dehydroascorbate.
What are the official names of this protein?
2,3-diketo-L-gulonate-binding periplasmic protein YiaO, 2,3-DKG-binding protein, Extracytoplasmic solute receptor protein YiaO.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRUD_SALTY
Sequence: MTEFDNLTWLHGKPQGSGLLKANPEDFVVVEDLGFTPDGEGEHILLRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDFSAFQLEGCKVLEYARHKRKLRLGALKGNAFTLVLREISDRRDVETRLQAIRDGGVPNYFGAQRFGIGGSNLQGALRWAQSNAPVRDRNKRSFWLSAARSALFNQIVHQRLKKPDFNQVVDGDALQLAGRGSWFVATSEELPELQRRVDEKELMITASLPGSGEWGTQRAALAFEQDAIAQETVLQSLLLREKVEASRRAMLLYPQQLSWNWWDDVTVELRFWLPAGSFATSVVRELINTMGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: SFTPD_RAT
Sequence: MLHFLSMLVLLVQPLGDLGAEMKTLSQRSITNTCTLVLCSPTENGLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLPGPRGPVGPKGENGSAGEPGPKGERGLVGPPGSPGISGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGAKGPAGPKGERGAPGEQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGAPGDRGIKGESGLPDSAALRQQMEALNGKLQRLEAAFSRYKKAALFPDGQSVGDKIFRAANSEEPFEDAKEMCRQAGGQLASPRSATENAAVQQLVTAHSKAAFLSMTDVGTEGKFTYPTGEALVYSNWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF
What is the function of this protein?
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins.  Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response.  May participate in the extracellular reorganization or turnover of pulmonary surfactant.  Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
What are the official names of this protein?
Pulmonary surfactant-associated protein D, PSP-D, SP-D, CP4, Lung surfactant protein D.
What is the protein family that this protein belongs to?
Belongs to the SFTPD family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Protein: RL30_BURMS
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DTD_PECCP
Sequence: MIALIQRVSSASVTVEGKVIGEIDKGLLILLGVEQGDDEQKATRLCERVLGYRIFGDDDGKMNLNVRQAGGNVLVVSQFTLVADTQRGMRPGFSRGAHPSEADRLYQYFVGQCREQGVHTETGQFAADMKVALVNDGPVTFWLQT
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOEB_ECOL6
Sequence: MKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation.  Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides.  YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity).
What are the official names of this protein?
Toxin YoeB, Putative endoribonuclease YoeB, Putative mRNA interferase Yoeb.
What is the protein family that this protein belongs to?
Belongs to the YoeB family.
Protein: HIS6_ROSS1
Sequence: MLKRRIIPCLDVKAGRVVKGVAFLNHRDAGDPVELAAAYDAGGADELVFYDITASSDERAIMVDVVERTAAQVFIPLTVGGGLRTVEDMYRMLRAGADKVSINTAAVLNPQLIEDGARRFGSQCIVLSIDARRVNASDEPPRWQVFTHTGRDPRPTGLDAIEWARRGVELGAGEIVINSMDEDGVGGGYDIDLLRAITEAVNVPVIASGGVGSPEHMYAGLVEGRADAVLAASIFHFGAYTIRDVKQYLAERGVPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_CLOB8
Sequence: MKAYKKEFINFMIECGVLTFGDFVTKSGRKTPFFVNTGNYQTGSQLRRLGEFYAEAIKENFADDYDVLFGPAYKGIPLSVTTSIALSSSFDIDVRYCSNRKEVKDHGDTGILLGSKLNDGDKVLIVEDVTTAGTSIYETMPILKSQADVNVKGLIISVDRMERGQGEQSALTEIREKFGFKTCAIVTMAEVIEYLYNKEINGTILITDEVKGRIDEYYKQYGAK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ERG6_DEBHA
Sequence: MPSAVQLAEKNHEKDSKFAKALHGESYKQTGLKALMSKARDASEVANDGYFKHWDGGVTKEDEDKRLSDYSNLTAHYYNLVTDFYEYGWGSSFHFSRYYTGEAFRQATARHEHFLAHKMQINENMKVLDVGCGVGGPAREICRFTDCSIVGLNNNDYQIERANHYARKYKLDDKLSFVKGDFMQMDFEAESFDAVYAIEATVHAPVLEGVYSEIYKVLKPGGVFGVYEWVMTDKYDDENEEHRKIAYGIEVGDGIPKMYKREVAEKALKSVGFEIEYEADLADKEDDIPWYYPLSGEWKYVQTLSDYFTIFRTSKVGRTITTEAVGLMEKLGLAPKGSKQVTNALEDAAVNLVEGGRQKLFTPMMLYVCRKPANEDI
What is the function of this protein?
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
What are the official names of this protein?
Sterol 24-C-methyltransferase, Delta(24)-sterol C-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: MATK_LATAP
Sequence: MKEYPVYLEQARSRQQDFLYPLLFREYIYGLAYSHNWNRSIFLENGGYDNKYSLLIVKRLITRMYQQNHLIISANDSTKNPFGGYNKNLDSQIISEGFAIVVEIPFLLQLSSSLEEGEILQSYQNLRSIHSIFPFLEDKLTYLNYVADIRIPYPIHLEILVQILRYWVKDVPFFHLLRLFLYHFCNRNSFITTKKSISTFSKSNPRLFLFLYNFYVCEYEYFFVFLRTQSSHLRFQYFSVFFERIFFDAKREHLVKVFSKDFSYTLTLFKDPNIHYVRYQGKCILTSKNAPFLMNKWKHYFIHLWQCFFDIWSQPRMININPLSEHSFQLLGYFLNVRLNRSVVRSQMLQNTFLIEIVIQKLDIIVPILPLIRSLANAKFCNIVGEPISKPVWADSSDFDIIDRFLRICRNLSHYYNGSSKKKSLYRIKYILRLSCIKTLACKHKSTVRAFLKRSGSEELLQEFFTEEEEILSLIFPRDSSTLQRLHRNRIWYLDIIFSNDLVHDE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ARF5_HUMAN
Sequence: MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAVLLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR
What is the function of this protein?
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
What are the official names of this protein?
ADP-ribosylation factor 5.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor.