PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_KINRD
Sequence: MEGPLLAASLPASAPNSTYIGNQSPRTVSGRYSFGKIHEPLEVPDLLALQTDSFDWLLGNKRWQDRVEASTNGGLAVPTTSGLEEIFEEISPIEDFSGSMSLSFRDHRFEPPKYSLDDCKERDLTYSAPLFVTAEFINGNTGEIKSQTVFMGDFPLMTDRGTFVINGTERVVVSQLVRSPGIYFERVPDKTSDRDTWTAKIIPSRGAWLEFEIDKRDTVGVRVDRKRKQSVTVLMKALGWSESQIREEFADYESMISTLEKDHTSGVEDALLDIYRKLRPGEPPTQEAARNLLDNLYFNPKRYDLAKVGRYKVNKKLGTEEPLSDSVLSVDDIVRTIKYLVKLHAGEVTMPGVKNGQPVDVRVEVDDIDHFGNRRLRSVGELIQNQVRTGLSRMERVVRERMTTQDVEAITPQTLINIRPVVASIKEFFGTSQLSQFMDQTNPLAGLTHKRRLSALGPGGLSRERAGMEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSSYGRINPFGFIETPYRKIVDGVVSDEVEYLTADEEDAFVIAQANAPLDADSRFAEARVLVRAKGGETEFVPRDEVDYMDVAARQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVKSEAPLIGTGMEFRAAVDAGDVVVATKAGVATDVSADMITTSNDDGTSTTYKVAKFRRSNHGTAYNQQVVINEGDRVEVGTVLADGPSTDGGEMALGRNLMVAFMPWEGHNYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVAEEVLADLDERGIIRIGAEVRDGDLLVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGETGTVIGVKVFDRDEGDELPPGVNQLVRVYVANKRKITDGDKLAGRHGNKGVISKILPVEDMPFLEDGTPVDVILNPLGVPSRMNVGQVLELHLGWIASRGWKIEGQPDWAKLIPEEIREAPAGSRIATPVFDGAREEEITGLLSSTIPTRDGDRLVGGDGKARLFDGRSGEPFPDPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYALQELLTIKSDDVLGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQSLCLNVEVLSSDGMAIEMRDSDEDVFRAAEELGIDLARREPSSVEEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RL3_RICBR
Sequence: MRTGIIAQKVGMTSVFNNNGKRVPLTLVKVDDCQVVGHKIAEKHGYNALVIGIKDKKISRVTKPMKQVFANAKVSPKTKLKEFRISEDNFIDIAASLEVDHFTAGQFIDVTATTIGKGFAGSMKRHNFRGLEASHGVSISHRSHGSTGQRQDPGKVFKGKKMAGHMGCSQVTIQNLKIFAIDKEQGLIMIQGSIPGHKGSYISIKDAIKKISITA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PGXC_ASPNC
Sequence: MSVFKASFLFLLSSSLVHGVPHSSRASRSQQCVVPSKYQASNGMADDSVAVSQAFAQCATDSVIIFEEGVNYNIFQPITATNLSNVEIRMHGNLHLPQNITAVQNIVSDGTSTWFTLEGPKVDWIGPEDVNNGWIDSYGQPWWDANPAGSSGIDNRPHLMSFKSSQATMKYFRSRKPIAWNVKLHGQDITVSHAIIDATSTGSFPFNTDGFDVEGTNIQITDSIMYNGDDAIAVGADSHDTLFTRNTIGYQTHGMSIGSLGKDPTDFANISNIRFDDVTVVDGLYAARFKSWSGGTGLVKNVTWNNIRVFNVTFPIFVTQSYSDQGASRSGTVNASSAVMMEDFTWSDFAGSINTYQPGDGSCVSDPCWYNVGLPNLKHTEALIIECHTAQSCKNFVTDNIQLYPQVLEPASVICMNATAALNPDLGFTCKNGTYSPLSN
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase C, Galacturan 1,4-alpha-galacturonidase C, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLD_PSYWF
Sequence: MNDATATRLDGKALAKQIETELSQRVAAVIKKTGRTPILATILVGDDPASATYVRMKGNACKRVGMESIRVEMPASTTTEQLLAKIDELNNNPDVHGILLQHPVPEQIDERACFDAIDLNKDVDGVTSLGFGRMSMGEPAYGSCTPQGIMYLLERYFLKNGIEFAGKNAVVVGRSAILGKPMAQMLLNANCTVTICHSKTQNLEEHVGRADILVGAVGVPELIKKDWIKPGAIVVDAGFHPTEDGGVGDIELKGIESIAAAYTPVPGGVGPMTINTLIRQTVEAAEKAAQA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PURA_POLAQ
Sequence: MSSKQQAQGRNVVVIGTQWGDEGKGKVVDWLTDHAQAVVRFQGGHNAGHTLIIGDKKTILRLIPSGIMHKDVICYIGNGVVLSPEALFKEIGELEAAGLDVQSRLKISEATTLILPYHVAIDHAREKKRGEAKIGTTGRGIGPAYEDKVARRALRVQDLFYPEKFAEQLRENLEYHNFMLTNYYGAEPVNYEKTLAEAMSYAERLKPMVVDVSSALYAAEQAGQNLLFEGAQGTLLDIDHGTYPYVTSSNCVAGNAAAGSGVGPDSLQYILGITKAYCTRVGAGPFPSELYDHDNPARQDPIGVRLAEVGKEFGSVTGRPRRTGWLDAAALKRSIQINGLSGLCITKLDVLDGLETIRLCVGYNLDGKKLDVLPRGAESVARCEPIYEDFPGWKGTTFGIREWEKLPVEAQNFLRRIEEVAGKPIAMVSTGPERDETILLQHPFQD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_OPITP
Sequence: MPLKLTRRQYAEMFGPTVGDRVRLADTDLLVEVERDLIAEGGGYGNEIKFGGGKVIRDGMGQSPTARDADSLDLIITNALILDSRLGVIKADLGIKHGLIVGIGHGGNPGIQSGLGSTFVDPRTGKKNPMIVGAATEVIAGEGCIVTAGGIDTHIHFICPQQIEEAISSGITTMLGGGTGPATGTFATTCTPGAWNLRRMIEAAEAYPMNLGFLAKGNCGTPAPLREQVLAGAIGLKLHEDWGTTPAAIDVCLGVADEFDVQVAIHTDTLNEAGFVEATIRAFKGRTIHTFHSEGAGGGHAPDIIRVCGEPNVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLDTKIPEDVAFAESRIRPETIAAEDCLHDLGAISIMSSDSQAMGRVGEVIIRTWQTAHKMKQQFGALAGGAHPAADNFRALRYLAKYTINPAIAQGIAHVVGSLEVGKLADLVLFKPALFGVKPELVLKGGFIAWANMGDPNASIPTPQPTFYRPQFGAAGRALTSTSLTFVSQAALDHGTFRDAGLARRLEPVKHCRRIGKRDMVLNDALPHIEVDPETYTVKADGRVLTCEPARELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4651_RALSO
Sequence: MPVVRVSWFEGKDAKAKKAVAAEITDSIVKHAGTDPKYIYVIFEDIKPSDWAGAGRLYGEEPGTP
What are the official names of this protein?
Probable tautomerase RSp1151.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: SDU1_SCHPO
Sequence: MKVYINVYDLMPDSPVNKLAWTLGLGIYHTGLVLEGKEYAFGAHEIPGSTGVFATMPRPPLEGCRWRCSIALPNCTLPKPDVDRILIRLSQEFTGLSYSLLERNCNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTITNALLQHGQKNTSDVDDSSDSSSDVDEETLIVSKSKKAHKDIPKFSAPPPSADLNNLITDSLP
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
DeSI-like protein sdu1, Meiotically up-regulated gene 67 protein.
What is the protein family that this protein belongs to?
Belongs to the DeSI family.
Protein: SPEE_SALEP
Sequence: MAENTMWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVETITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFTLVIDDGVNFVNQTHQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEALDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSSEIIQARFHAAGLKCRYYNPAIHAAAFALPQYLHDALSAQ
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOVO_ANSCA
Sequence: VATVDCSDYPKPACTVEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: NDHI_LAYHE
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTIFNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: NADE_STAAM
Sequence: MSKLQDVIVQEMKVKKRIDSAEEIMELKQFIKNYVQSHSFIKSLVLGISGGQDSTLVGKLVQMSVNELREEGIDCTFIAVKLPYGVQKDADEVDQALRFIEPDEIVTVNIKPAVDQSVQSLKEAGIVLTDFQKGNEKARERMKVQFSIASNRQGIVVGTDHSAENITGFYTKYGDGAADIAPIFGLNKRQGRQLLAYLGAPKELYEKTPTADLEDDKPQLPDEDALGVTYEAIDNYLEGKPVTPEEQKVIENHYIRNAHKRELAYTRYTWPKS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RECR_RUEST
Sequence: MAAQDNSDIEALIALMAKLPGLGPRSARRAVLHLIRKRALVLTPLADAMSRVAETARECLNCGNVGTSDICALCEDETRANGELCVVEDVADLWAMERAGVFKGRYHVLGGTLSALDAIGPEDLRIPRLVDRVSTEGVSEVILALNATIDGQTTAHYIADQLSGRVKLTSLAQGVPIGGELDYLDDGTISAALRARKEI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: MVP_SBWMN
Sequence: MGSQDVKGDSYESVYNKILDMQSEPGGANDLRTNRQRSFNIENRYVEKALTQPGVVTKMQDAWTNWTKTNKEEGTPYNMSYSCVLLNVIPTVPMGYAGTVEVSLLDSGLSPLENVIPDQTQMMELGKGPHVMCFFMHYSIPLNDKGRAVKLAFKIDAEMASKGMSVMNVYSYWTQRQGHLSAYSEPQRSTISKLMLGYDKSLKMKTRNDVRRFVGRSLSLHNQEQSVPALLPGQINVMKENVPLYRKESVIDLTREEREKAAQLEMLRKTREVHTQRSAEEMKRRQAELAKDTQRKLAEEAKAVTEKRKNMAGVNSSNIKFGNFDSV
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.
What are the official names of this protein?
Movement protein, 37 kDa protein, Cell-to-cell transport protein.
What are the subcellular locations of this protein?
Host cell wall. Host cytoplasm.
Protein: ULAC_ECOL6
Sequence: MKLRDSLAENKSIRLQAEANTWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFSLVTLKKPLEFNHEDNDPVDILITMAAVDANTHQEVGIMQIVNLFEDEENFDRLRACRTEQEVLDLIDRTNAAA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II UlaABC PTS system is involved in ascorbate transport.
What are the official names of this protein?
Ascorbate-specific PTS system EIIA component, Ascorbate-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_SHEFN
Sequence: MKGQILREMHVLKAIEPEFEIQRRIAFIKATLSEAHSKTLVLGISGGVDSSLAGRLCQLAVNSLNQEKASDEYQFIAVRLPYHVQQDEAEAQLACQFIQPSKQVTVNVHDGVVGIHNATLKGLTAAGLSSTDAGKTDFLKGNVKARMRMIVQYDIAGAMGGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRLLAAHLGAPEILVKKAPTADLEDNKPQLEDEVALGLTYDQIDDFLEGKDVAKSVEDKLVSIYKRTQHKRKPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: G3P_METBU
Sequence: MTKVKVAINGYGTIGKRVADAVALQDDMEIIGIAKTRPNFETVMAKDKGFNVYTLADRVGAMEKEGIEVSGTVEEMIKAADVVVDCTPGKVGATNKDLYEKAGIKAIWQGGEAHTLTGCSFNAETNYDEALGKDFVRVVSCNTTGLCRVLSPLDKEFGVKKARVTLLRRAADPGDIKTGPINAIVPNPIKLPSHHGPDVKTVIPNIDIATTAVKLPTTLMHLHTINLELEKECTAEDVESVLAEQSRVRFVGQGITSTAEIMELAKDLGRSRGDMWENCIWNESITMYEGELYFFQAIHQESDVIPENIDAIRAMMELESDASRSIEITNKTMGI
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_LEPIN
Sequence: MNSSSNEKNKDLNRKNFSSKTDSSNNKAVVLLSGGLDSTTCLYQAIADGKEIQALSFDYGQRHKIELSYAKKVTRKLGIPHTIQKLKPELFLGSSLTQKSLHVPKNSLRKEEIPNTYVPGRNILFLSFAVSLAEGTGSDSIYIGVNSMDYSGYPDCRPEFIKMFEMAIQLGTKKGSQGPSIKILTPLQNLSKKEIVLLGNQLKVPFHLTFSCYDPKNGKACGKCDACLLRKKGFQETGVSEK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: JAMM1_HALVD
Sequence: MTSSRLSLAADARDSILSHAREGAAGDPPAEVCGVLAGDSDARTVTAAHPVSNVAAEPRVAYELDPEETVSILEAIESAGDDAVGFYHSHPESDPVPSATDRERASWPGYVYLICSPDGRMTAHEWTGDEFRELSVAVE
What is the function of this protein?
Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked).  Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification.  Functions as a specific and not a general protease since it is unable to hydrolyze a variety of unmodified proteins otherwise hydrolyzed by proteinase K.
What are the official names of this protein?
Desampylase, HvJAMM1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67B family.
Protein: Y1229_STACT
Sequence: MNNYDKTMRFNLDDVPKENVKSVLTNVYNTLKERGYDPVNQIVGYLLSGDPAYIPRHNEARNQIRRIDRDEIMEELVSNYLNASKDN
What are the official names of this protein?
UPF0297 protein Sca_1229.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: NR2C1_PONAB
Sequence: MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDNSSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFVNIHPSGVKTESTVLMTSDKAESCQGDLSTLASVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMHTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPGLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNIRIDSVIPHILKMEPGQYSKTSSL
What is the function of this protein?
Orphan nuclear receptor.  Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism.  Primarily repressor of a broad range of genes including ESR1 and RARB.  Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription.  Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences.  Also activator of OCT4 gene expression.  Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation.  Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 2 group C member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all- trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation.
Protein: HEMA_I80A7
Sequence: QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGRDCTLIDALLGDPHCDVFQDETWDLFVERSNAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPASGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTNLYVQASGGVTVSTRRSQQTIIPNIGSRPWVRGQSGRISIYWTVVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNADVLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDIYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: TRPB_SALA4
Sequence: MTTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEFQAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMFADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGRADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKMMREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RR3_STIHE
Sequence: MGQKIHPYGYRVGITQPHSARWFANTYQYPQYVFEDFLLRQSLFKNLPVENLPRKRTEDKSETKLVQIKIERLIRNTIKIKLYVTSPENASELFEHEALTKSPKKDFGTTNSNKRNLQTNLESKKDRNTLRLNIQKRLLNKKLLQLQILKLQNMQSKLVTMKNLLDGSQNTNKKVFSSSVFVQKNETETIVNNYPFYLNNIAINYSIGKTLIEGIKDCLNMNLDGKKKVKYLFYFLQLKKQLSKTLLYQLDVYQKVEKQKLVNFTGLNKSEEQISAFQNTINLRLFKLKALSLKWTNHSRHLTNVLVSIQSKLTLELETLVSKLDQNKTNLNQKCATLINILKFKYMLRKNNFNKLELFVLNQKIEEIKLKWFQSLTIAGTVQAETDSQSDFYSSKKILLELNMISCEKQKMLTLLTKFKFSLNFYNTHLEKTKRIILAGLFLLSKFGWKKEIFNGLNTFLSQSVLIIKKLETHLGKNYKILQERIIVKINHMTILESTIKQNLNLLQILKIAQDHNTNRDKIKVSQLYKNLFKVFYLTSLSSTPAFHETLTNKTFLYDLVSESLDKYALLISQKVINLNSSLICYSEEKTTQIPVYNDKFLNILTREYLSNLIRLFKNDSINYYKSKALYQFSLALLNQRYKLNKIIEMKIKNLLLQIKPEEKTKNTFLVSIRDLNISLKSNTLFIKQLETWLTLLKKKLTENTATNRYLLQARIHKINCYLKKIIPVKITENNLVSTIEKNFIFVNYNILKQKLLAELLQMQQTIILAKKEEWEKEESLSFPPSTSFFTKTNISIGNLNQTLQILQNRILDLQGRFNQENQQKTAGKTVNTDLSPILQVENKTNVSKTLQLKTTLQQLLKTNYENSFIVLQTRRQVYNSIINRLGGHRKFGKSRAGEKENIWKNPYETAEYLDFKLKKVNNSTDTNSLTTLLETIKQKIYERKPIKLMYTRKQKFLAKKTIKKKLKHFLVLMALKNNYTNLSSLKNIYDVKTFAKLCENLTNLQTMPKVSVIELVKVHQPKQYAVCLANFVVENLEKRFSFRSTMKRASEQAMSTANVKGIKIQISGRLNGAEIARTEWLRDGVVPLQTLRANIDYSYKTAKTIYGILGVKVWLFKDTPANMNS
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS7_BACCR
Sequence: MPRKGPVAKRDVLPDPMYNSKLVTRLINKMMVDGKKGKSQTILYNAFDIVNERTGKEPMEVFEQALKNIMPVLEVRARRVGGANYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEERLANEILDAANNAGASVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: IKKB_BOVIN
Sequence: MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEMDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCFKALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLALIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRNLPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQGFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSHPCQLMSQPCTAPDSLPEAAEKSEDLVAEAHTLCTQLENALQDTMKEQDQSLRSLDWSWLQSEEEEQQSLERAS
What is the function of this protein?
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses.  Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues.  These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome.  In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.  In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.  IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs.  Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.  Also phosphorylates other substrates including NCOA3, BCL10 and IRS1.  Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity).  Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).  Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (By similarity).
What are the official names of this protein?
Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, Serine/threonine protein kinase IKBKB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.