PharMolix/UniProtQA huggingface dataset:
Protein: VIF_HV1SC
Sequence: GVSIEWTKKRYSTQVDPDLADRLIHLYYFDCFSESAIRNAILGALVSGRCEYQAGHNKVGSLQYLALTALITPKKTKPPLPSVRKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of APOBEC3G.  Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions.  Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery.  Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1.  Binds viral RNA and affects the stability of viral nucleoprotein core.  May play a role in viral morphology.  Interacts with host ABCE1, which seems to be involved in lentiviruses capsid formation and displays RNase L inhibitor activity.  This interaction may play a role in protecting viral RNA from damage during viral assembly.  May interact with host SAT, which is a regulator of polyamine cell level.  This interaction may be relevant since polyamines affect viral RNA properties (By similarity).
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion (By similarity).
Protein: TRMFO_STRMU
Sequence: MSQSYINVVGAGLAGSEAAYQIAKRGIPVKLYEMRGVKRTPQHKTSNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRTGEAHRVPAGGAMAVDRSGYAQAVTAELENNPLIQVIRNEVTEIPDDAITVIATGPLTSDSLAKKIYKLNGGEGFYFYDAAAPIVDQSSIDMDKVYLKSRYDKGEAAYLNCPMTKEEFIRFYEALINAEEAPFNSFEREKYFEGCMPIEVMAKRGIKTLLYGPMKPVGLEYPQDYKGPRDGDYKAPYAVVQLRQDNAAGSLYNIVGFQTHLKWSEQKRVFSMIPGLEQAHFVRYGVMHRNSYIDSPNLLAPTFATCKNPNLFFAGQMTGVEGYVESAASGLVAGINAVRRFKDEEAVIFPQTTAIGALPYYITHTKSKHFQPMNINFGIIKDLGGPRIRDKKKRYEKIAERSLKDLQQFLTV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_ECO5E
Sequence: MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGSLTCLRWEDKQYFVQPSNRHKDLGEGEAVAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: CPFC_STAAR
Sequence: MTKKMGLLVVAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHKDGITEAITVVLAPHYSSFSVGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRDLYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIVDEIKSIF
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIA_SALTI
Sequence: MTTMDNTPQGELVLRTLAMPADTNANGDIFGGWLMSQMDIGGAILAKEIAHGRVVTVRVEGMTFLRPVAVGDVVCCYARCVKRGTTSISINIEVWVKKVASEPIGQRYKATEALFIYVAVDPDGKPRPLPVQG
What is the function of this protein?
Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.
What are the official names of this protein?
Acyl-CoA thioester hydrolase YciA.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
Protein: SYK_METJA
Sequence: MHWADVIAEKLIEERKADKYIVASGITPSGHIHVGNARETLTADAIYKGLINKGVEAELIFIADTYDPLRKLYPFLPKEFEQYIGMPLSEIPCPEGCCESYAEHFLRPYLESLDDLGVELTTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRANPLPDDWWPINIVCENCGKLKTKVIKYDSEKEEITYRCEICGFENTVKPYKGRAKLPWRVDWPARWSIFNVTIEPMGKDHAAAGGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTNIAHPEILRFLLLRSKPTKHIDFDLKKIPDLVDEYDRLEDFYFNNKDKDELSEEEQEKIRIYELSTPKIPETKPFVIPYRFCSIIAQLTYDEEKEDINMERVFEILRRNNYSIDDIDEFSMKKLKDRLLMARNWALKYGEKLVIISEDEAKEIYEKLKDKQKEWIKYFAEKLKTAEFDALNLHELIYQTAKELGLNPRDAFQASYMILLGKKYGPKLGAFLATLGKDFVIRRYSLFE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGR6_HUMAN
Sequence: MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  May act as a tumor suppressor.
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYG2_THEVB
Sequence: MTIPLLSYAPSSQNQRVAGYEVPNEETPWRYSLEDAVDQSDIDELIWAAYRQVFSEHVVLKSTRQPHLESQLANRAISVRDFIRGLAKSETFRRLVVETNSNYRLVEIALKRLLGRAPYNKQEELAWSIRIATDGWQKFVDTLVDSDEYTQNFGDNTVPYQRRRYKDRPFNLVTPRYSDYWRDKLENSRYKWGDIRNFLEMARSVKVTPVQFKPVSTANVQIPDTTRRDRPTVPASINPTASFPLR
What is the function of this protein?
Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
What are the official names of this protein?
Phycobilisome rod-core linker polypeptide CpcG2.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RAB7_NEUCR
Sequence: MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTREVLVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFDALDSWRDEFLIQASPRDPDNFPFVVLGNKIDMEESKRVISTKRAMTFCQSKGNIPYFETSAKEAINVEQAFEVIARNALMQEESEEFSGDFQDPINIHIENDRDGCAC
What is the function of this protein?
Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport.  They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane.  In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI).  In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion.
What are the official names of this protein?
Ypt/Rab-type GTPase Rab7, Guanine triphosphate binding protein 14.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: YJCK_BACSU
Sequence: MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYTVEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDKAHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNVKINGVWEDHQVLAILNPDDEQ
What is the function of this protein?
Acetylates the N-terminal alanine of ribosomal protein S5.
What are the official names of this protein?
Putative [ribosomal protein S5]-alanine N-acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. RimJ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_LISW6
Sequence: MEKSVNVIGAGLAGSEATWQLVKRGIKVDLYEMRPVKQTPAHHTDKFAELVCTNSLRANGLTNAVGVIKEEMRILDSIIIESADKASVPAGGALAVDRHEFSGYITEKVKNHPLVTVHTEEVTSIPDGPTIIATGPLTSPALAEEIKQLTGEDYLYFYDAAAPIIEKDSIDMDKVYLKSRYDKGEAAYLNCPMSEEEFKTFYEALVTAETAALKEFEKEVFFEGCMPIEVMAKRGIKTMLFGPLKPVGLEDPKTGKRPYAVLQLRQDDAAGTLYNMVGFQTHLKWGEQKRVFGLIPGLENAEIVRYGVMHRNTFINSPTVLEPTYQLKTRDDLFFAGQMTGVEGYVESAASGLAAGINAANFVQEKETIVFPAESAIGSLAHYITSASKKSFQPMNVNFGLFPELPSKIRAKQERNEKLAERALDAIKKVAEQV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOA2_DICDI
Sequence: MDSSLFSLKNSFGGFNDEELLRVQKIIEDLELTESIVSKEWVTFALQKKIAEDYSKHLDPFKVFLKKNIKKLKVQKTTEQIKEVAEEDPKMFENVEIEDIIFDTDSLVDESEIPKIKDEPSSSVDVSTARNKNNHNNNNNNNPSLPNKSMFKPTKQEMTNDNIKKVVIADDIGDFDFTTANQPIKQSNPTQLLNYKERKNIGGISYSMNNNEELKTDLSLREKKSCDLKGAGEEFYPIKYHRDTLEQRTKILKESVQSNNYTFPVSLDCQDDESIVRSVGRVWMYDQETILSKRFYLLGNERDSSSSGGSSGSASIFSLENNIPDYSMFSGQVVMAESKKIAGSHFYYTNKLYTPNPLPFFSQRKECGDINVMIASGPFDLQKSTPDYTPLDDLCNVVSNKKPHILFLMGPFIDESNVHIKKYSETFSELFNNLMKKLNDNIPSTTKVLIVPSLNDVDHEYIFPQPPYVPSVNLNSNILFVPNPFTLIINESFTIGITSSDIYNNLVSKAHFKNKHTPEDIFNMIINQNNYYPMHPAQAPISMRYLQHLNFPGFTPDILVVPKNSPIAAISNDVLCLGVPPIVGNKSTFGSYAELTVTKSKQSLAFDNNIPVSKRTIVNFKNI
What is the function of this protein?
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
What are the official names of this protein?
DNA polymerase alpha subunit B.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase alpha subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROA_CLOBA
Sequence: MGTFKIYPGKLKGEVKIPPSKSMAHRGVICAALGDGISKIRNINYSDDIRATINAMRSLGAIITKEDEYLHIIGIKSEKCKKNIELNRTIDCNESGSTLRFLVPISCIFEGSSRFIGKGNLGKRPLDTYYEIFDNQGIKYSYKKGKLDLRIQGILKYGEFKLRGDISSQFISGMLFTLPLLEGDSKIIITTELESKGYIDLTLSAMSDFGIEIINNNYREFIIKGNQTYKSIDYRIEGDYSQAAFFLVADALKSEVFINDLKLESLQGDKEVIEILERMNMKIKNIDNSLLGIPRENLEATIIDGSQCPDIIPVISLAASLCNGRTEIINVGRLRIKECDRLSAVASELNKLGANIIEKEDSLIIDGVKTLKGGVKVWSHKDHRIAMMLAIASTVCMEPIILEDYECISKSYPEFFDDFKALGGNFHEWNLGE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y611_MYCPN
Sequence: MLRVARLSRLALLSLTAVIFSGCANINLISAVGSSSVQPLLSKLSSHYVLNHNDKDNLVEISVQAGGSSAGVKAITKGLADIGNVSKNTKSYAEENKQLWMDKKLKTITLGKDAIAVIYKAPSEFKGKLVLTKDNLNDLYDLFAGSKSVDINKFVENGQTTKNSNHNLIGFPRTGGAFASGTAEAFLKFSGLTQTKTLDKDSKEILEGQRNYGPNARPTSETNIEAFNTFVTTLRQPNLYGMVYLSLGFVNNNMNLIKSEGFEVLKVKYDNNAVTPSSQAVSSNTYKWVRPLNSVVSLLPKQKTLPSIQRFFNWLLFSNNSEIKKIYDDFGVLELTADEKKKMFKTGNAEMSNIANFWVDDYSLNNQTFGAL
What are the official names of this protein?
Uncharacterized lipoprotein MG412 homolog.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ZAPD_SHIFL
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELNRQQRKLQTWIGVPGVDQSRIEALIQQLKAAVSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: SUMO_CAEEL
Sequence: MADDAAQAGDNAEYIKIKVVGQDSNEVHFRVKYGTSMAKLKKSYADRTGVAVNSLRFLFDGRRINDDDTPKTLEMEDDDVIEVYQEQLGGF
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825).  Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837).  Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625).  Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540).  Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704).  Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).  Plays a role in male tail tip morphogenesis (PubMed:21408209).  Plays a role in the mitochondrial stress response with its covalent attachment to transcription factors dve-1 and afts-1 negatively regulating the mitochondrial unfolded protein response (PubMed:30642431).
What are the official names of this protein?
Small ubiquitin-related modifier, SUMO, Ubiquitin-like protein SMT3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=At the first embryonic mitotic division, enriched in the nucleus and released to the cytoplasm when the nuclear envelope breaks down at the start of mitosis. During mitosis, localizes to the metaphase plate and to the centrosomal region. Also localizes to segregating chromosomes at the beginning of anaphase. At late anaphase and telophase, observed in the spindle midzone and in the two daughter nuclei.
Protein: MBOA5_DROME
Sequence: MAEFEEDLPHNGLMDGIASGVGVPVEALRLLLTILAGYPVAALYQKFISVIADKTVHHMFFAGCGAGLCYFNYGLDTYHSLIAILTTYFLVLLLRKKTQIFLAINFVFHMSYLLLGYFYTSSNDYDILWTMPHCILVLRMIGYGFDITDGLKEESELSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFVDGEFRQHEGNVEAGVRRFGAGAFYLIVCQVGLRYLPDSYFLTPEFAQVSFVKRIYLLGFWAKFSLYKYISCWLLTEGALICIGLTYKGEDKNGQPDWSGCSNVKLKLLETGNTMEHYVQSFNVNTNQWVGQYIYKRLKFLNNRTISYGAALGFLAVWHGYHSGYYMTFLMEYMVVSTEKQITRFYTKVVLPQWGHILNNSDIYKLLYFITLKSYNVVYMGWCLTAFVFLKYERWIVVYGAVSYYGFTFLVLWAAFYHTFNHFFRSSSRKLAGEDQKLQDSNTDKLVEEKKPEDKKSE
What is the function of this protein?
Acyltransferase that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids).  Highest activity with lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) producing phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), but also converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity).  Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA).  Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature.  Essential for fertility and viability together with Oysgedart (Oys).  Required for germ cells to migrate into the mesoderm.
What are the official names of this protein?
Lysophospholipid acyltransferase 5, LPLAT 5, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, Lysophosphatidylcholine acyltransferase, LPCAT, Lyso-PC acyltransferase, Lysophosphatidylserine acyltransferase, LPSAT, Lyso-PS acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 5, O-acyltransferase domain-containing protein 5, Protein nessy, Nes.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Protein: ANGT_MOUSE
Sequence: MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYHNKSTCAQLENPSVETLPESTFEPVPIQAKTSPVNEKTLHDQLVLAAEKLEDEDRKRAAQVAMIANFVGFRMYKMLNEAGSGASGAILSPPALFGTLVSFYLGSLDPTASQLQTLLDVPVKEGDCTSRLDGHKVLAALRAVQGLLVTQGGSSSQTPLLQSIMVGLFTAPGFRLKHSFVQSLALFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKMNLPLEGVSTDSTLLFNTYVHFQGTMRGFSQLPGVHEFWVDNSISVSVPMISGTGNFQHWSDAQNNFSVTCVPLGERATLLLIQPHCTSDLDRVEALIFRNDLLTWIENPPPRAIRLTLPQLEIRGSYNLQDLLAEDKLPTLLGAEANLSNIGDTNPRVGEVLNSILLELKAGEEEQPTTSVQQPGSPEALDVTLSSPFLFAIYEQDSGTLHFLGRVNNPQSVV
What is the function of this protein?
Is a ligand for the G-protein coupled receptor MAS1 (PubMed:12829792).  Has vasodilator and antidiuretic effects.  Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (PubMed:12829792, PubMed:18026570).
What are the official names of this protein?
Angiotensinogen, Serpin A8.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AB10I_ARATH
Sequence: MNGHCLFAASPPRLFPLRSISSSVSPSGSYRIKFSDNVAVECRNLCFSVSTRQGISVPILRDCSFRIPSGQLWMILGPNGCGKSTLLKILAGVVNPSSGTVFVEKPKNFVFQNPDHQVVMPTVEADVAFGLGKYHDMNQEEVKSRVIKALEAVGMRDYMQRPIQTLSGGQKQRIAIAGALAEACKVLLLDELTTFLDESDQMGVIKAVKDLINAKKGDVTALWVTHRLEELKYADGAVYMENGRVVRHGDAATISDFIKAKQSSYIDQIGS
What are the official names of this protein?
ABC transporter I family member 10, ABC transporter ABCI.10, AtABCI10, Non-intrinsic ABC protein 13, Protein EMBRYO DEFECTIVE 2751.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCI family.
Protein: RS15_XANP2
Sequence: MSITAERKQALIKDFGAKDGDTGSPEVQVAILTERITNLTGHFKSHHKDNHSRRGLLKLVSQRRSLLDYLKKKDEGRYKSLIERLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RPIA_COXB2
Sequence: MSKNELKKAAAMEAIQFVKNVNIVGVGTGSTVNYFIDALAEIKHQIEGAVASSVATENRLKEHRIPVVDLNSVSNVDVYVDGADEFNKHFYLTKGGGGALTREKIIAAAAKRFICIVDESKQVDVLGQFPLPIEVIPMARSFVAREIVKLKGDPVYRQGFTTDNGNVILDIHNLTILNPVELEAILNNIPGVIANGLFAQQPADDLLIGTPAGVQLHHRK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RL21_METS3
Sequence: MQRSRGFRSKSRRKMTKVVREGRSNPITNKLQKFEEGDLVHITINPSIQKGQPHPRFHGKTGKITDKKGKAYIVSLTDGNKAKELIIRPDHLKLQTSQ
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: DNAK_BARHE
Sequence: MAKVIGIDLGTTNSCVAVMDGKNAKVIENSEGARTTPSVVAFTDGGERLVGQPAKRQAVTNPEGTIFAVKRLIGRRFDDPMVEKDKALVPYKIVKGDNGDAWVEEAGKKYSPSQISAMILQKMKETAESYLGEKVEQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKDGKTIAVYDLGGGTFDISVLEIGDGVFEVKSTNGDTFLGGEDFDMRLVGYFADEFKKEQGIDLKNDKLALQRLKEAAEKAKIELSSSQQTEINLPFITADQSGPKHLTMKLTRAKFESLVDDLVKRTVEPCKAALKDAGLKAGEIDEVVLVGGMTRMPKIQEVVQSFFGKDPHKGVNPDEVVAMGAAIQGGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTKKSQVFSTADDNQNAVTIRVFQGEREMANDNKLLGQFDLVGIPPAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEHQIRIQASGGLSDADIEKMVKDAEEHAAEDKKRREGVEARNQAEALIHSTEKSLTEYGDKVSTEEKEQIETAISDLKSVLDSTDTEEVKAKMQKLAEVSMKLGQAMYEASQAATPNTETDTKSDDVVDADFEEINDKKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FOLD_STAA2
Sequence: MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEAKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPSLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.