PharMolix/UniProtQA huggingface dataset:
Protein: PEF1_XENLA
Sequence: MASYPYGQGYHGAAGQPPGAPQTNYYGGQQYGGGVQPAASYGRPAPGAPYGSPPSGGVYGHPVPGSAAPGAPGGPYGGQAPGGPYSVPGSTPYGSQQHGSYGQGAPAGNIPPGVDPEAFSWFQTVDTDHSGYISLKELKQALVNTNWSSFNDETCTMMMNMFDKSNSGRIDMFGFSALWRFIQQWRNLFQQYDRDRSGSINQGELHQALCQMGYQLSPQFVQIVMSRYAQRSAQPGLQLDRFIQICTQLQSMTEAFREKDTGQIGTAKLSYEDFITMTTTRLL
What is the function of this protein?
Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium.  Acts as a negative regulator of ER-Golgi transport (By similarity).
What are the official names of this protein?
Peflin, PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein.
Protein: LGT_AERHH
Sequence: MQHDGYWVFSQIDPVAFSLGPLSVRWYGLMYLFGFAFAMWLAGRRADAPNSGWTRNEVSDLLFYGFLGVILGGRVGYVLFYNFDMFLADPLYLFKIWTGGMSFHGGLIGVITAMVWFAHKTNRHFFTVADFVAPLIPFGLGVGRIGNFLNGELWGRVTDVPWAIIFPEAGPEPRHPSQLYQFALEGVVLFIILNLFWRKNPPRGAISGMFLLFYGLFRFLVEFVRQPDSQLGLYFQEISMGQILSTPMIIIGALMIWVAYKRPQLFGNSVKEAK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DTX1_HUMAN
Sequence: MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA
What is the function of this protein?
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).  Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.  Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context.  Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1.  Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation.  Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
What are the official names of this protein?
E3 ubiquitin-protein ligase DTX1, Protein deltex-1, Deltex1, hDTX1, RING-type E3 ubiquitin transferase DTX1.
What is the protein family that this protein belongs to?
Belongs to the Deltex family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Protein: HBBA_CAPHI
Sequence: MLTAEEKAAVTGFWGKVKVDEVGAEALGRLLVVYPWTQRFFEHFGDLSSADAVMNNAKVKAHGKKVLDSFSNGMKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVVVLARHHGSEFTPLLQAEFQKVVAGVANALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-A, Alanine beta-globin, Beta-A-globin, Hemoglobin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TAP51_BPT4
Sequence: MANIIRCKLPDGVHRFKPFTVEDYRDFLLVRNDIEHRSPQEQKEIITDLIDDYFGDYPKTWQPFIFLQVFVGSIGKTKSTVTFICPKCKKEKTVPFEIYQKELKDLVFDVANVKIKLKFPSEFYENKAKMITENIHSVQVDEIWYDWKEISESSQIELVDAIEIETLEKILDAMNPINLTLHMSCCNKYIKKYTDIVDVFKLLVNPDEIFTFYQINHTLVKSNYSLNSISKMIPAERGFVLKLIEKDKQ
What is the function of this protein?
Chaperone that is involved in the formation of the central hub of the baseplate.
What are the official names of this protein?
Baseplate hub assembly protein gp51, Gene product 51, gp51, Hub assembly chaperone gp51, Tail assembly protein gp51.
Protein: ACPS_MAGMM
Sequence: MIVGIGNDLVEIQRLTNMLNKGHGQRFLERCFTQQEQQLCNGRSTPQRACCYAKRFAAKEAVIKALGVGFRQGLWFTDIEVLPNQLGRPTVTLHGATAQWLACHHPGQVNIHLSLSDEKGLAIATALIECHPLAMAPS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCYIA_PANJA
Sequence: ADXQPGDSTDKLLAQKQDDV
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit Ia.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TRMB_SHESR
Sequence: MSEVTTAEFNEEGKYLRKIRSFVLREGRLTKGQAQAIETQWPTMGLDYSPTPLNLTEVFGREADTVLEIGFGMGASLVQMAQEAPEQNFIGIEVHKPGVGSCLSDAAAAGVTNLRVYHHDAMEVLEHAIADGSLARVQLFFPDPWHKKRHHKRRIVQAEFAELIRRKLKIGGVFHMATDWENYSEHMLEVMNAANGYKNQSADGTVVPRPDHRPLTKFEARGHRLGHGVWDLMFERIA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: OBG_BORBZ
Sequence: MYNFKDSVNITVVSGNGGSGCVSFLREKFNAKGGPDGGNGGSGGSVIFKVRENLSTLSFYKNGHVLCAENGKPGMGFKRSGANGKDLTLFVPPNTEVYNENDGTLLYRLKNLNDEFVVLKGGRGGLGNWNFKTSVRRVPRFAQPGESGNSLSVRLELFLVADIGLVGLPNAGKSSLLNRITSAKSRVANYPFTTKIPHLGMLRRSYDDLIIADIPGIIKGASFGVGLGTKFLKHIAKTKILALVIDISEANFLESYNILLNELKSYSHKLFNKKKIIIANKLDLDGSEKNFDCLIKALGKEKVVGISIYENRGIDELIKEFFILAKTF
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVB4
Sequence: MAARLCCQLDPARDVLCLRPVGAESRGRPFPGPLGALPPASPPVVPTDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHGNLPKVLHKRTLGLSAMSTTDLEAYFKDCVFNEWEELGEEVRLKVFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: SYK_YERPP
Sequence: MSEQKPQVAEQAQELNSELQARREKLAVLRGKGIAFPNDFRRENLSDQLHAEFDSKENEELEALNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDDLPEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDDMDKAVAIAESLGIKVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKEAGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_CAMLR
Sequence: MAVPKRRVSKTRAAKRRTHYKVTLPMPIKDKDGSYKMPHRVNPVTKEY
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: TPS8_COFAR
Sequence: MACTSNLSSLSKSWAVLDVPRGAPKATGLWLKRQFIFKTSRICMCMPTPTATQPIATPLIRDNESLLKYLRQPSVLPHEVDDSRKELLGRTRRQLRSTSEPLKAMNLIDTLQRLGLAYHFEDDMNAILSQLSSSGQSDGDLLTTALRFRLLRHNGHKIVQKFMDKNGKFKDSLKEDTMGLLSLYEASHLAANGEDILLEAMELTEAHLKQSLPSLPTQLARKVSSALELPRHRRMARLEARRYIQEYSEEIGHDPNLLELAKLDYNKVQSLHQMELTEISRWWKQLGLVDKLTFARDRPLECFLWTVGILPEPKYSNCRIELAKTIAILLVIDDIFDTHGTIDELVLFTNAIRRWDLEAMEGLPEYMRICYMALYNTTNEICYKILKENGWSVLPYLKATWIDMIEGFMLEASWYNNGQEPNMEEYVANGVTTAGAYMAMVHLFFLIGQGVTEENVKLLMKPYPKLFSCSGRILRLWDDLGTAKEEQERGDLASSIQLFMRENNITCDEEGRKRILQLIDNLWKDLNWELVSRDAMPLAIIKAAFNMARSSQVVYQHEEESYFSSVDNYVESLFFTPIIN
What is the function of this protein?
Monoterpene synthase (mono-TPS) involved in the biosynthesis of monoterpenes natural products, constituent of coffee beverage aroma.
What are the official names of this protein?
Putative monoterpene synthase 8.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsg subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACKMT_RAT
Sequence: MERGETPEEERQSGCVLPTSPESDSLKTSNWGFLITGVIGGALVTVYAVTTPFIAPALRKVCLPFVPATSRQVENVVKMLQHRRGPLVDIGSGDGRIVIAAAKAGFPAVGYELNPWLVWYSRYRAWREGVHGSAKFYISDLWKVTFAQYSNVVIFGVPQMMPQLEKKLEFELEDGARVIACRFPFPHWTPDHTTGEGIDTVWAYDMSACRTQGKRA
What is the function of this protein?
Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2.  Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (Probable).  Promotes chronic pain.  Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (By similarity).
What are the official names of this protein?
ATP synthase subunit C lysine N-methyltransferase, Protein N-lysine methyltransferase FAM173B.
What is the protein family that this protein belongs to?
Belongs to the ANT/ATPSC lysine N-methyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein. Note=Localizes to mitochondrial cristae.
Protein: COBS_BRUME
Sequence: MQRNGLIGDTIRSLGFLSRLPLPQGWFDNTDDSLPRNARAFPLAGGILGLLAGVALLIANAISLPPLAAALIAIGALAAMTGALHEDGLGDTADGFFGASTPDRRLDIMKDSRIGTFAALTLVIWTGVKASLLMAIIARAGAGYALLALIGTEAASRAGMLAFWHALPSARPGGLADSMGQPQWETVVCGCGLGLALLAIGFLPSGGMVALINALVLMTVVLFGFARLCMAKIGGRTGDTLGAAQQIGSLAALIGLVMAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRF_HAEDU
Sequence: MDNKIIVALDYETENEALNFIDQVDPSLCRLKVGKEMFTTLGAHFVKQLHDRKFDVFLDLKYHDIPNTVARAVRSAADLGVWMVDLHASGGLTMMEEAKKILEPYGKDAPLLIAVTVLTSMEDLDLLQIGINASPMEQVIRLSHLAKRAGLDGVVCSPQEVEVLRTHCGDDFKLVTPGIRPAGSDFGDQRRVMTPKQAIQTGADFLVIGRPITQAQEPLSILKAINASIA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TIM22_DROME
Sequence: MSVLPNAGNNESSVTAPKMFGDPDLDRMAMEYVGNMQRYRENIIIPKSNGPVKIKTNEEKFIETAVESCGFKCTMACVMGYGLGAALGLFSASVNPNMADPFANEKKQTAREVFREMRSTTHSYAKNFALIGCVFSAVECTIESHRGVTDWKNGTYAGGITGGLIGLRAGVKAGIIGGLGFAAFSTAIDYYMYSR
What is the function of this protein?
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel.  Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim22.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL5_STRP7
Sequence: MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEAVSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTTANTDEESRALLTGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: SYI_VIBC1
Sequence: MSEYKDTLNLPETGFPMRGNLANREPEMLKRWYKEDLYGEIRKAKKGKKSFVLHDGPPYANGDIHIGHALNKILKDIIIKSKTLSGFDAPYIPGWDCHGLPIELMVEKKVGKPGQKVTAAEFREKCREYAAGQVEGQKESFKRLGIMGEWDKPYRTMDFATEANIIRALGKIASKGHLLKGFKPVHWCTDCGSALAEAEVEYKDKVSPSIDVRFKAADEAALLSKFELTEGHEGQGDISIVIWTTTPWTLPANRAVCLRDDLEYVLIQTEGDNAERIIVAAELAKDVMDRAGIEHFHNLGFAKGADLELSQFQHPFYDFTVPAILGDHVTTDSGTGVVHTAPGHGQEDFAVGNKYNLEVANPVGSNGVYLPDTELFAGQHVFKANDAVVEVLKEKGALLHHHAYEHSYPHCWRHKTPIIFRATPQWFVSMDQAGLRAKALESIKNVEWMPEWGQSRIEGMIEGRPEWCISRQRTWGVPIALFVHKETAELHPNTLELIEKVAKLVEEKGIQAWWDVDAAELLGADADQYEKVLDTLDVWFDSGVTHFSVVDAREEYNGNSADLYLEGSDQHRGWFQSSLISSIAMKDEAPYKQVLTHGFVVDGHGRKMSKSIGNVVAPKDVTNKLGADILRLWVASTDYTGEVAVSDEILKRSADAYRRIRNTARFFLANLSGFNPETDIVPVEEMVALDRWAVGRALAAQEEIVKAYEEYNTHGVTQRLMQFCSIEMGSFYLDVIKDRQYTAKRGGNAQRSCQTALYYIVEALVRWMAPIMSFTADEIWNEMPGQRDKFVFTGEWFDGLFGLAEGEELNNEFWTEIQAVRGAVNKLLEDARKEKTIGGALQAEVTLFADDALAAKINKLEDELRFVLLTSAAKVKPLGEKTDAAQATDIEGLFVEVAAAEGEKCDRCWHHTPDVGTIEGHEKICGRCVSNVDGEGEVRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_YERPG
Sequence: MKIDLNADLGEGCANDQALLQLVSSANIACGFHAGDAQTMRQSVRWALEYGVAIGAHPSFPDRENFGRTAMQLPPETVYAQVVYQLGALAAIVQVEGGVMQHVKPHGMLYNQAAVDPLLADAIAQAVKAVDPSLRLVGLAGSELIRAGTRVGLVTRQEVFADRHYQPDGTLVPRSQPDALIESDELALSQTLAMVQQHQVQACDGSWVQVQADTVCVHGDGVQALAFARCLRDRFQQEGISVIAQ
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: NCAP_I68A4
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGTKVSPRGKLSTRGVQIASNENMDAMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPFDKPTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEMSFQGRGVFELSDEKAANPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CAV2_PONAB
Sequence: MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSGQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRSFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: DCUP_ACIB5
Sequence: MTTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKADLDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGSSKEFRFTKQMMYAQPEVLHALLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDGRRIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGSAASIEKAVKAMLDDAYANGEKTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNA5_MAIZE
Sequence: MASLTDLVNLDLSDCTDKIIAEYIWVGGSGIDLRSKARTVKGPITDPSQLPKWNYDGSSTGQAPGEDSEVILYPQAIFKDPFRKGNNILVMCDCYTPQGEPIPSNKRYKAATVFSHPDVAAEVPWYGIEQEYTLLQKDLSWPLGWPVGGYPGPQGPYYCAAGADKAFGRDVVDAHYKACLYAGINISGINGEVMPGQWEFQVGPSVGISAGDEIWVARYILERITEMAGIVLSLDPKPIKGDWNGAGAHTNYSTKSMREAGGYEVIKEAIEKLGRRHREHIAAYGEGNERRLTGRHETADINTFKWGVANRGASIRVGRDTEKEGKGYFEDRRPASNMDPYVVTGMIADTTILWKGN
What is the function of this protein?
Plays a role in the flow of nitrogen into nitrogenous organic compounds.
What are the official names of this protein?
Glutamine synthetase root isozyme 5, GS117, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_ECOSM
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.