PharMolix/UniProtQA huggingface dataset:
Protein: DLTA_BACC3
Sequence: MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAAAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTSTPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMYQSSIPMTPNGKVDRKKLLSEVTA
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CY550_SYNP2
Sequence: MNKILGIDPLKKFIFGISAFVLLFWQLNVGAANATALREVDRTVNLNETETVVLSDQQVAKGERIFINTCSTCHNSGRTKSNPNVTLSLVDLEGAEPRRDNILAMVDYLKNPTSYDGELDLSQLHPNTVRADIWSSMRNLNEEDLQNVSGYVLVQAQVRGVAWGGGKTVN
What is the function of this protein?
Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.
What are the official names of this protein?
Cytochrome c-550, Cytochrome c550, Low-potential cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PsbV subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: SYS_BACC3
Sequence: MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMHRDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGKTVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAM50_SCHPO
Sequence: MSGHTDADEIHEILRNSTTGLVHLKDYQRVKQNIVEKREKHALSTTSTKIKKRKDALSKKVKQGIKVNKGKLSFGEDEELENDDLPLKKVEKKMFMGKDPSADTSFLPDAEREIRENAKRAEYRKQWLKEQEQIREKEILIPFIYYDGTSTTYHVRTRLKDSVGHFLADMKQQIPFLKRILDMDKFLLVQSDLIIPHHHELYYFYINKVQGRDGLLFDFDKLSCSSPEMVATTQLPSQCIPHLVQKSYYLQNRHVFPCVHWEVFDSRKDYSLEKHATDPNAALFYRPS
What are the official names of this protein?
FAM50 family protein C1020.12c.
What is the protein family that this protein belongs to?
Belongs to the FAM50 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DB118_MACFA
Sequence: MKLLLLALPILVLLPQVIPAYGGEKKCWNRSGHCRKQCKDGEAVKETCKNHRACCVPSNEDHRRVPTTSPTPLSDSTPGIIDNILTIRFTTDYFEISSKKDMVEESEAGQGTQTSPPNVHHTS
What is the function of this protein?
Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E. coli and S. typhimurium, and Gram-positive bacteria, such as S. aureus and B. subtilis (By similarity).  Inhibits cell adhesion of E. coli on intestinal epithelial enterocytes (By similarity).  Causes rapid permeabilization of both the outer and inner membrane of E. coli, leading to morphological alterations on the bacterial surface (By similarity).  Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (By similarity).  May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (By similarity).
What are the official names of this protein?
Defensin beta 118, Beta-defensin 118.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPIA_ACTP7
Sequence: MTQQEMKKIAAQAALQFVKPDTIVGVGSGSTVNCFIDALASMKDQIKGAVAASKASEERLRAIGIEVFNANEVSELDVYIDGADEITPQGAMIKGGGAALTREKIVSSLAKKFVCIVDGSKQVDVLGTTFPLPVEVIPMARSYVARQLVALGGSPEYREGVVTDNGNVILDVHNFHIIEPLKMEHTINNIAGVVTNGIFAQRYANVTIVGTPEGAKIIE
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CLPX_SALTI
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRTHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLTGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIANRVETGSGIGFGATVKAKSDKASEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALVQILKEPKNALTKQYQALFNLEGVDLEFRDEALNAIARKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIAGQSKPLLIYGKPEAQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TFR1_CHICK
Sequence: MDHARAALSNLFSVEPMSYTRFSIARQTDGDNSHVEMKLSADDEEGGDIERPEHMHVSMAQPQRNGKRLCFLVIAAVLLLLIGFLIGYLSYRGRIELAARCQDGSGGCEITPTASYLVDGEGTVEEEIQGPPVIFWPELKAMLSKKLSAKNLVDNLRWRVGVDSFEAGEAEDTNMATYIHEEFRNFLDKVWNDEHYIKLQVRGSTKNQVSISINGKEEILETPDAIVAYSESGSVSGKPVYVNYGLKKDFEIIQKVVASLNGTIVIVRAGKITLAEKVANAKEAGAAGVLMYVDSLMYGITDTLIPFGHAHLGTGDPYTPGFPSFNHTQFPPVESSGLPHIAVQTISSSAAARLFSKMDGDTCSEGWKGAIHSCKVTTKQESQIMVKLDVNNSMKDRKILNIFGAIQGFEEPDRYVVIGAQRDSWGPGVAKAGTGTAILLELARVISDIVKNEGYKPRRSIIFASWSAGDYGAVGATEWLEGYSAMLHAKAFTYISLDAPVLGASHVKISASPLLYMLLGSIMKGVKNPAAVSESLYNRLGPDWVKAVVPLGLDNAAFPFLAYSGIPVLSFGFYNKDEEYRFLDTKGDTLENLRKIDNLDALLAAAAEVAGQAALRLTHDHELFLDIGRYSEELLAYQEEFLPYIKEVRELGLTLDWLFFARGDFQRAVTALRRDIANSDGENRVIRRALNDRMMKVEYDFLSPYLSPKDVPFRHIFFGKGPHTLRSLVEHLQLLKTNRSSVDLNLLREQLALATWTIKGAANALGGDIWETDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: NCRK_ARATH
Sequence: MKMRVETALAILLVLISIQQCYGGVSNYTCTCFSSGNRSDILESNCSTSCNCRPDRDQWVCLCPANGFPVIAIGGSNSSCFTSCNCSAGATKSSKKQYLSRKLVIVILLFCGVLISLAFLASMICYICRKDKFSGQTPSVSSDRESSWHSSANLINRKSSVSQSKISISSSVAGCFFQNASLFCVSKPETIHGAIFQFSYTELEQATNKFSSNSVIGHGGSSCVYRGQLKDGKTAAIKRLNTPKGDDTDTLFSTEVELLSRLHHYHVVPLIGYCSEFHGKHAERLLVFEYMSYGSLRDCLDGELGEKMTWNIRISVALGAARGLEYLHEAAAPRILHRDVKSTNILLDENWHAKITDLGMAKCLSSDGLQSGSSSPTTGLQGTFGYFAPEYAIAGCASQMSDVFSFGVVLLELITGRKPIQKPSNNKGEESLVIWAVPRLQDSKRVIEELPDPRLNGKFAEEEMQIMAYLAKECLLLDPESRPTMREVVQILSTITPDTSSRRRNFPINYLFQSNEKKKESKVGWSRGGSKSGQEEETVDLTEPRFESFCLPNVKPVLLEPSAHI
What are the official names of this protein?
Receptor-like serine/threonine-protein kinase NCRK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane. Endosome.
Protein: HPCL1_PIG
Sequence: MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRSEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDPSIVRLLQCDPSSASQF
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
What are the official names of this protein?
Hippocalcin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: SYGA_AGRFC
Sequence: MNPKRSFQALILTLHNYWADKGCAVLQPYDMEVGAGTFHPATTLRALGPKPWKAAYVQPSRRPSDGRYGENPNRLQHYYQYQVILKPNPSNLQELYLGSLKAIGLDPLLHDVRFVEDDWESPTLGAWGLGWECWCDGMEVSQFTYFQQVCGIECSPVAGELTYGLERLAMYVQGVDNVYDLNFNGREGEEKISYGDVFLQAEQEYSRHNFEFADTSMLHRHFIDAEKECLALLAAGAPGDNDNQRLHKCVFPAYDQCIKASHIFNLLNARGVISVTERERYIARVRDLAKACGEAFLLTDAGGLNWNRAA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB2_RHOPA
Sequence: MSVALAGSPATNSAQYEPLRVMIVDDSVVIRGLISRWVEAEPDMVVAASLRTGLDAVNQLERVKPDVAVLDIEMPELDGISALPQLLAKKRDLVVIMASTLTRRNAEISFKALSLGAADYIPKPETTREPQAADIFKHDLLQKIRSLGGRVRRRAVPGVAAPAIAREPHPAPLPHPAVATPTVASQAALVKRSFGPTAPRVLLIGSSTGGPQALMSMVADIGPVIDRFPVLITQHMPPTFTTILAEHLARASRRPAHEGIEGEAIKPGNIYLAPGGKHMRVAKQGGNPVIALDDGPPVNFCKPAVDPLFMSAIEVWQGGILAVVLTGMGSDGMRGGKDIVAAGGSVIAQDEASSVVWGMPGAVANAGVCAAVLPLNQIGPKVVRLFAGDRS
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase of group 2 operon.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_PSEF5
Sequence: MSTPSAPANPKVGFVSLGCPKALVDSERILTQLRMEGYDVVSTYQDADVVVVNTCGFIDSAKAESLEVIGEAIKENGKVIVTGCMGVEEGNIRDVHPSVLAVTGPQQYEQVVNAVHEVVPPKQDHNPLIDLVPPQGIKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGDVLDEAQRLVKSGVKELLVISQDTSAYGVDVKYRTGFWNGAPVKTRMTELCEALSTLGVWVRLHYVYPYPHVDELIPLMAAGKILPYLDIPFQHASPKVLKAMKRPAFEDKTLARIKNWREICPELIIRSTFIVGFPGETEEDFQYLLNWLTEAQLDRVGCFQYSPVEGAPANDLDLEVVPDEVKQDRWERFMAHQQEISSARLQQRIGKEIEVLIDEVDENGAVGRCFFDAPEIDGNVFIDGAGDLKPGDKVWCRVTDADEYDLWAETL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_HAEIE
Sequence: MSEIKLNYHKTHFLTSAPNIRSIPEDTGIEIAFAGRSNAGKSTALNALTNQKNLARTSKTPGRTQLINLFEVEPNYKLVDLPGYGYAAVPEQMKIQWQKSLGEYLQKRECLSGLVVLMDIRHPLKDLDQQMIEWAVSADLPILLLLTKADKLSQSARSKQVKMVREAILPFQGDIQVEAFSAQNKIGIDKLAAKLDFWFSPLFAK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: GHC1_BOVIN
Sequence: MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYTSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRYQLSKDGQQLTLFKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRLAAQRKILSAQAQLSGQGSAQPSVEAPATPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSIVYFPLFANLNELGRPASGEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGINEDTYSGFLDCARKILQNEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAETLLGLPRVQP
What is the function of this protein?
Mitochondrial glutamate/H(+) symporter.  Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity).  Plays a role in the control of glucose-stimulated insulin secretion (By similarity).
What are the official names of this protein?
Mitochondrial glutamate carrier 1, GC-1, Glutamate/H(+) symporter 1, Solute carrier family 25 member 22.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MRAZ_XANAC
Sequence: MFQGETAITVDDKGRMAVPTAYRDLVARVSGNRLVLTYNPFEAGCLWLYAEKEWERVRDDVMSKPNTQRVVRTLQQKLVGSSAVLELDANGRLSIPASHRNAVGIEKKAVLLGMGDKFELWSEQAHRALIQQTLSDGDLGDELLDLRL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RV203_MYCTU
Sequence: MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAASEVARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLHALSQPLTDLSTRCSLPISGLQAIGLMQAVQGARR
What is the function of this protein?
Part of a heme-iron acquisition system.  Acts by binding heme and delivering it to the membrane proteins MmpL3 and MmpL11.  Can use free heme or heme from host hemoglobin.
What are the official names of this protein?
Heme-binding protein Rv0203.
What are the subcellular locations of this protein?
Secreted.
Protein: NUSB_BURP0
Sequence: MKKSARRQSRELATQGLYQWLLSNAAPGEIDAQLRGALGYDKADKTLLDTILHGVIREHATLAEAISPSLDRPIDQLSPVERAVLLIATYELTHQIETPYRVIINEAVELAKTFGGSDGYKYVNGVLDKLAVKLRPAETQARRGA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: Y3874_MYCTO
Sequence: MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDAAGDGIWSMYTNRTLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLATADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATLRQHGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPARAQDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAAKLVETEISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPELLARYGRSIPHSGEDSIPPNLFVSAQRATS
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MT3874.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: COX2_TAMSO
Sequence: MAYPFELGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINDPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTSDLSPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATLTSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFENWSSSML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACR3_CORGL
Sequence: MTNSTQTRAKPARISFLDKYIPLWIILAMAFGLFLGRSVSGLSGFLGAMEVGGISLPIALGLLVMMYPPLAKVRYDKTKQIATDKHLMGVSLILNWVVGPALMFALAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDMSCGDREATAVLVAINSVFQVAMFGALGWFYLQVLPSWLGLPTTTAQFSFWSIVTSVLVFLGIPLLAGVFSRIIGEKIKGREWYEQKFLPAISPFALIGLLYTIVLLFSLQGDQIVSQPWAVVRLAIPLVIYFVGMFFISLIASKLSGMNYAKSASVSFTAAGNNFELAIAVSIGTFGATSAQAMAGTIGPLIEIPVLVGLVYAMLWLGPKLFPNDPTLPSSARSTSQIINS
What is the function of this protein?
Catalyzes the proton motive force-dependent arsenite efflux from the cell.  Probably functions as an arsenite/H(+) antiporter.  Does not transport antimonite.
What are the official names of this protein?
Arsenical-resistance protein Acr3.
What is the protein family that this protein belongs to?
Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AI3_USTMA
Sequence: MVLEQYFLLLPEFNLNTIRVSNNPSGSAAKPLFMYNRDGSICYYKSTKQVDFVRTFGIHKVTFMKHLEQGTYYLNKYLFSMEELPNAEQSDMTVEQVATMLDIDRVTNNKNKTLVSFSVAVTLINIETKEEHKFPSLGTAVKFLKNGSYPADQRTLVKRINTNIPYHGFTCHKY
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded DNA endonuclease aI3.
What is the protein family that this protein belongs to?
To endonucleases of group I introns of fungi and phage.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SEP15_MOUSE
Sequence: MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFASEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
What is the function of this protein?
May be involved in redox reactions associated with the formation of disulfide bonds (By similarity).  May contribute to the quality control of protein folding in the endoplasmic reticulum.  May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).
What are the official names of this protein?
Selenoprotein F, 15 kDa selenoprotein.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein M/F family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
Protein: RL6_SALAI
Sequence: MSRIGRKSIPVPAGVDVTIDGQTVKVKGPKGELSHTLAEPITVERAEDGQLNVARPNDERKAKELHGLSRTLVANMIVGVTEGYRKSLEIAGTGYRVTAKGKDLEFALGFSHPVTVVAPEGITFSVEKPTLFHVAGINKQLVGEVAANIRKIRPPEPYKGKGVKYQGEVIRRKAGKAGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: MADS1_VITVI
Sequence: MGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRLYEYANNSVRTTIERYKKVCSDSSNTGSVSEANAQFYQQEASKLRRQIRDIQNLNRHILGEALSSLNFKELKNLETRLEKGISRIRSKKNELLFAEIEYMQKREIELQNSNLFLRAQIAENERAQQQMNLMPGSQYESVPQQPYDSQNLLPVNLLDPNHHYSRHDQTALQLV
What is the function of this protein?
Probable transcription factor involved in flower development.
What are the official names of this protein?
Agamous-like MADS-box protein MADS1, Agamous homolog 1, VvAG1, VviAG1, MADS-box protein 1, Vvmads1.
What are the subcellular locations of this protein?
Nucleus.
Protein: URED_CYTH3
Sequence: MVKDTTHSILEISTIHGKSSVTGSKIFRPLKIFALEKNKACHLVFSNYGGGFVEGDSIDLTIDCKADTVSAFSSQANTRIYRSEHGKTCKQTITGTVGENALVVFMGDPVVPHQKSIFEQHLFWKLEKNAVLLVIDWFEAGRILNGERFAFDSFFTELKIESNGVPIVWDRFKMDPSQNNMNSPGAFLDHSSYINIFLAGDENLTRVKSIETQLRFLAAQYFHEHIENKSESLIRIGSAVKVNEQVFMIRCSAKNNDLLQPFVKALAEHMSDKELLGFNPFEGRN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACIR_BOVIN
Sequence: MEVDVNGESRSALTTLPLPVAEASSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGAEESKGEAVPSLRSKQLDVGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT
What is the function of this protein?
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages.  The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis.  May play also a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B.  May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells.
What are the official names of this protein?
Macrophage immunometabolism regulator.
What is the protein family that this protein belongs to?
Belongs to the UNC119-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm.