PharMolix/UniProtQA huggingface dataset:
Protein: RIMM_RHIE6
Sequence: MKEPMTKLENPVLMATIGGAQGLRGEVRAKAYTADPTALGDYGHLHSMDGRSFEILEIREMKNVVVVRFRGINDRNAAEALNGLELYIERDNLPDEELEDDEFYYADLEGLEARDDQGVSYGTVTGVFDFGAGDLLELKGPGKRPVLIPFSEASVLEIDLEAGTLLIDPLAAGLVDDPEELSKFTPDKPKKKK
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG55_BPML5
Sequence: MSILTTAEEIINGQRAQDYGDAKENHERIATLWGAYKRGVEFTPEDVAVMMILLKIARFMENGYHQDTVVDIAGYAGVLEKMQLPEDERYPKGPRQWDTLLDVPADVKTVTNATGVKWIYYPNGLHHTKVGKRRWSGGNASSHEERMRGPFTEVAE
What are the official names of this protein?
Gene 55 protein, Gp55.
Protein: RLMH_FERNB
Sequence: MKIELIVPGKLSKHLQPAFDYYVEKLNRFAKISVHFVELGGDLNTEDEKTILKKEAEHIKKRLKDRKFILLDLWGKELTSIEYARFLENTINKLSEIVFVIGGPLGIDDSLRENALAKISLSKMTFTHEMCVILFLEQTFRAFKILKNEKYHY
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5NT3B_RAT
Sequence: MAEEVSSLMKATVLMRQPGRVQEIVSALRRGGGDRLQVISDFDMTLSRFAYNGQRCPSSHNILDNSKIISEDCRKELTELFHHYYPIEIDPHRTIKEKLPHMVQWWSKAHSLLCQQRIQKFQIAQVVGESTAMLREGYKMFFDTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFSEDGFLKGFKGQLIHTYNKNSSVCENSSYFQQLRNKTNIILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILRQGDCVELQGS
What is the function of this protein?
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate.  The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids.  Also has weak activity for CMP.  UMP and purine nucleotides are poor substrates (By similarity).
What are the official names of this protein?
7-methylguanosine phosphate-specific 5'-nucleotidase, 7-methylguanosine nucleotidase, Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidase III-like protein, cN-III-like protein, N(7)-methylguanylate 5'-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the pyrimidine 5'-nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB1_RHOPS
Sequence: MTLPPAIPPTPADSMSVEEHMARSNLFTTLEDLTAWSRKHSLWPFNFGLSCCYVEQVTVLTPVYDQARFGAEVIRASPRQADLLVVSGTVFHKMAAPLLRLYEQMRAPRWVISMGACANSGGMYDIYSVVQGVDRFIPVDVYIPGCPPRPEAMLDALIMLQQQIGSERRPLGVTVGNTAGLGFDAPRRRDQRRDERMAQTLLDPPEKL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: 098R_FRG3G
Sequence: MLNYIHQLVKPQRICTFASVAWTAQCTRVSSIHWRAGKSFTFQNQPKWKSLAFWRAQKAWLHSHNG
What are the official names of this protein?
Uncharacterized protein 098R.
Protein: LIP3_MORS1
Sequence: MLLKRLGLAALFSLSMVGCTTAPNTLAVNTTQKIIQYERSKSDLEVKSLTLASGDKMVYAENDNVTGEPLLLIHGFGGNKDNFTRIADKLEGYHLIIPDLLGFGNSSKPMTADYRADAQATRLHELMQAKGLASNTHVGGNSMGGAISVAYAAKYPKEIKSLWLVDTAGFWSAGVPKSLEGATLENNPLLINSKEDFYKMYDFVMYKPPYIPKSVKAVFAQERINNKALDTKILEQIVTDNVEERAKIIAKYNIPTLVVWGDKDQVIKPETTELIKEIIPQAQVIMMNDVGHVPMVEAVKDTANDYKAFRDGLKK
What are the official names of this protein?
Lipase 3, Triacylglycerol lipase.
What is the protein family that this protein belongs to?
Belongs to the lipase/esterase LIP3/BchO family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DNAJ2_CUTAK
Sequence: MSTKDWAEKDYYKILGVSKDAKPEEIKKAFRKIARDNHPDSHPGDKAAEARFKEASEANDVLSNAKKRKEYDQARSLFGSAGGFRFPRGGAQTSVNVEDFLRTASNGDGFGDLFGNLFGASGGRRTASRSPRRGADVEGETTISFDDAVSGTTVTMDMVSQAPCQACRGTGARAGTVPRVCSTCQGSGMHASSAGGVFEMTEPCPDCHGRGMIVEDPCQVCHGSGRAKSTKSMQTRIPAGVEDGQRIRIKGKGSPGENGGKAGDLYVKVTVRPHEIFGRDGHNLTVTVPVTFPEATLGAEVEVPTLAGTTVRLRIPAGTPNGRTFRVRGRGVPRSDGSRGDLLATVEIAVPESLDDDARHVVERLRDSLPQATPRPWEVK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 2.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDT9_ARATH
Sequence: MAKLAEEMNPEGSRYQLLLSCPSGLSPSQVSVDFSKSHDRIPRQDPGLEDSISQVWEQRSQGNSSLFNGQKFRYGGYCLDDDDGSTNEVPHVCLRLGLTDYRTFVGTNLSSLWEKFLVTSEDDSVRCRHTSSPLGNGAVIETSDKKIIVLRRSNNVGEFPGHYVFPGGHPEPTAVGIDYHQLENNVQTGEVLNKKVTQEMFDSIICEVVEETGIPASSLSSPLFIGISRRELNVRPAMFFYLKCSHHSDDIQRLYSSAEDGFESTQLHTVSLDELKMMTSRMPGCHHGGFALYELMLQRLKNTKETSLIAT
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Nudix hydrolase 9, AtNUDT9.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: RBL_CUNLA
Sequence: VGFKAGVKDYRLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGXAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVPGEETQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFCFCAEALYKAQAETGEIKGHYLNATAGTSEEMMKRAVFARELGVPIVMHDYLTGGFTSNTSLAHYCRDNGLLLHIHRAMHAVIDRQRNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEVIREATKWSPELAAACEVWKEIKFEFD
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PMIP_COCIM
Sequence: MLKTLNRRSWTCRQCIRILRRNAETRRYFQGASAASPLCQHTVSSSTSDKARDDQTLRLIFDSEPFWREFSQPKSSTSKRTGLLQNQYLTGPDGFLQFAQVSLQKCQKIVAKVIAASTLEDYRGMVRDLDRLSDLLCRVIDMAEFMKLNHPSPQIQDAATQAYALMFEYMNVLNTTPELDAQLKRASADLNVTSHWSPEEKVAARVLLKDFSQSAIHLPPKDRQKFVALSNEISQLGPMFVTNRQPETDHVTVDKNKLRGMDPSLIQQLQRWRKVAVPMFGDIPRIALYSVHDEETRKEIYVTSRTSSKVQIRRLETLLQKRAELAKLAGFPSYAHMTLSDKMAKTPEAVVNFLEALNASNRGQVQDELSQLLALKQADVPSATQLQPWDHAYYVHQYSARHSRVRRSRESTLLPAFFSIGTVIQGLSRLFTRLYGIRLVPTETLPGEIWNPDVRRLDVVDESDRRLAVIYCDLFTRPYKSPNPTHFTLRGSREISQAEIAECADLSSSLHPNDGMATTIKPETNKLYQLPTVALICDFDQSESRSTPSLLNEHNLETLFHEMGHAVHSVLARTDLQTISGTRCATDFVELPSVIMENFATAPEVLALYARHWETNEPLPEHMVKSMELNRQSRVSMHGGMDNEVQILMALLDQAYHSSRPLEPNFDSTRIYHDVYSTHSSLPDPPGSRTSWQGYFAHLVGYGATYYSYLFDRAIANKVWSDVFKGGELSTNRDAGERFKNEVLRWGGGRDGWNCVAGLLGNNPANDNGKLAEGGEEAMREVGRWGLGLMGTSEL
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SARAF_PONAB
Sequence: MASACGPGAAGHCLLLGLHLFLLTAGPALGWNDPECMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWYSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLRGGSGSYSACSNSDTKTRTASGYGGTRRR
What is the function of this protein?
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling.  In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity).
What are the official names of this protein?
Store-operated calcium entry-associated regulatory factor, SARAF, SOCE-associated regulatory factor, Transmembrane protein 66.
What is the protein family that this protein belongs to?
Belongs to the SARAF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1- dependent manner following cytosolic Ca(2+) elevation.
Protein: COAX_JANSC
Sequence: MLLCIDCGNTNTVFSIWDGESWLCTMRTSTHHSRTADAYFTWFSTLLGHYGIDPQIDDVIISSTVPRVVFNLRVFCDRFFNLRPLVVGKPDCALPMEPRVDFGTGVGPDRLANAVGAFARHGGDCVVVDFGTATNFDVVAEDGAYVGGVIAPGVNLSLEALALGAAALPHVDITKPDAVIGTNTVACIQSGVFWGYVGLIEGITTRIKAEYGKPMKVIGTGGLAPLFAQGEVLFDTVEDDLTMYGLTVIHKYNKDKNPS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQ61_SCHPO
Sequence: MVTRRLSTNVHIDLQPIRQGILLPFHDRPAEMRDLAKCNDQFFRNVRDTISEPKFTQLMELWLEKSRAEVPDADFLMTTRNIMLSFPSNEEQGHQRSASHGSTSSATSTPKRLSISSMDPARIHLWRQFCNVVGYDMPTPGEQKEAPPSPAQEAIPESPVEEAIASDSDEEEEEEIKA
What are the official names of this protein?
Uncharacterized protein C191.01.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL31_RHOPA
Sequence: MKTEIHPDYHTITVVMTDGTEYQTRSTWGKEGDKLNLDIDPKSHPAWTGGTQQVLDRGGRVSRFQKKFSGFLKKD
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31, RRP-L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: HIS7_NITSB
Sequence: MIKIERQTKETDIVVELNVDGKGKSDIDTGIGFFDHMLESFAKHARFDVKVVCKGDIHVDFHHSVEDVGIVLGQAFYQSVFPVHNKERFGDAVIVMDESAVECAIDLSNRPFLVYEVDIDGTIGQFDAELIEEFFRAFVFNARITAHIIQKRGKNRHHLAEASFKALAVALRRALAEDKRAGMPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDK3_MOUSE
Sequence: MRLFYRLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPRVLDNFLNVLINIRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKSNRTF
What is the function of this protein?
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration.  Can also phosphorylate PDHA2.  Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet.  Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation.  Plays a role in the generation of reactive oxygen species (By similarity).
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL33_DESRM
Sequence: MRVGVTLACTECKRRNYTTAKNKKNDPNRIELKKYCKWCHTHTVHKETR
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: FADI_SALPK
Sequence: MRQALPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPADAIEQLVFGQVVQMPKAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKALARVLVDVNKARTTRQRLTLFSRLRLRDLLPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWAEGKLAEEVMTTYVPPYKNPFAEDNNIRGASTLADYAKLRPAFDRKHGSVTAANSTPLTDGAAAVILMTESRAKELGLHPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMADLTLFDMHEAFAAQTLANLQLLGSERFAREVLGRAQATGEVDDAKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_BURL3
Sequence: MSDVENQPFFNIQRVYLKDMSLEQPNSPAIFLEQDMPSVEVEVDVKADRLAESVFEVVVSGTVTAKVKDKVAFLIEAKQAGIFDIRNIPDEQLDPLVGIACPTILFPYLRSNIADAITRAGFPPIHLAEINFQALYEQRLAQLQQQAGAAAGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_HELPH
Sequence: MADIMDIKSILYTEKSLGLQEKGVLVVQTAQNVTKNQLKEVFKTYFGFEPLKINSLKQEGKVKRFRGKLGQRKSFKKFYVKVPEGASIAALGA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: BRXA_MAGSA
Sequence: MAEPRYKADIGGGSLKLPESRIIAGLLLEGVTEDQWRHAIEVENVLQRRSPGTAKRQSSLMRNRLETMGPELWQMVRDGSTQVAIQAVFAAAIKHSTLLGDFLDLVVRDQFRMFRPDLPRKMWDQYLEQCRNRDPLMPVWQDSTANKLADCVYRILVEVGYITDSKTYRLKSVRISGEVMSYLRENNEQYVIRCIQVSI
What is the function of this protein?
BREX systems (bacteriophage exclusion) provide immunity against bacteriophage.  Part of a type 1 BREX system which protects against dsDNA phage.  This system allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA.  Methylation of bacterial DNA by PglX guides self/non-self discrimination.
What are the official names of this protein?
BREX protein BrxA.
What is the protein family that this protein belongs to?
Belongs to the BrxA family.
Protein: CALC_PENDC
Sequence: MSEPQAPKKRAACDRCRTQKLRCLRVPDHPTDSCIRCARSRMECITSSSKRPGRPRNPNNARPQQSDPGPATCAETNPPLPAVDIPVQSLGTVDDWFNFGSLETDYEICSVPWDSVDSGFPMEGVTAAHSISSLSTPPPLVPSTTPTFLNTLATDTSVDEQFENEKCAQNEAEMLQPFGDNIDHGLHLSLLQRELSKQLFALNSMPWDMTKVMRITCLHDAEASASQVDSKYNSLAKIAKTSAEFAQLLCSIQTPIAGDGGSNVSKNASPLSSIHPRLSMADLLTILSCYMLTLSIYDSIFSRFTEQASHNPGAVNVVLQSAPKLYLGGIAVPPRLEMLSHLLCCLTSRQLRPIEMLLGLPDEYCIAWKRNGGSKEKQSGLFSGQSGQLLFSTLMRVETERAGEEKGGLGVIESLKETIRRIYEFD
What is the function of this protein?
Transcription activator that specifically regulates the expression of the gene cluster that mediates the biosynthesis of calbistrins and related compounds such as decumbenones.  Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells.  It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure.
What are the official names of this protein?
Transcriptional regulator calC, Calbistrin biosynthesis cluster protein C.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECR_METNO
Sequence: MPQAVAGPEIERLIQLLARMPGLGPRSARRAALQLIKKREALLAPLAEAMRVACERIVVCHECGNVDTSDPCTICRDHSRDPSILVVVEDVSDLWALERSGAVTARYHVLGGVLSALDGIRPENLNLSRLVERASVPEMREVILALNATVDGQTTAHYITELLAHLPVKVTKLAHGVPVGGELDYLDEGTLSAAIRQRTAF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: TOLB_DESVH
Sequence: MRHRSCFSLFAGLALVFCLAVGTAAAGPVQVDIYGPGQGSLNLAMAAPLGPTPGTPVSGMGVKLNGFINENLSFLPFLRLVDQRAILGGTVMQGYKSPDIDLKRFQLAGADLVVTAGWPQGDASGSFVELRVYEALSGKLVFGKAYSHVEDGLLPNVADRFCSDLMKALTGRGEFFKSTLAFVKHDGKNKRDVWLVKPVGRDLRKITNLPGEALSPSWSPDGRFVVFSHFDDRSHALGVWDRLTRQVQRIRFPGNTVIGPCFLPDNKVAVSLSSGRNPDIFLLNHLFKKERELEANPSINVSPSFDATGTKMAFTSSRMGGPQVFMKDMTTGQVTRISKTGSYNTEPSISPDGTLVAFTKMTDTGHRIFVYDMVTQSERQVSFGPGRDEQPSFAPDSYFLAFTSNRNGAQQIFLVTRHGGDPKRVPTGPGDASFARWGMIPE
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FADB_ESCF3
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLVEGAKAILRQAINGDLDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPQVEPARAVGDLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: INS_SHEEP
Sequence: MALWTRLVPLLALLALWAPAPAHAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCAGVCSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAU20_YEAST
Sequence: MVKLTSIAAGVAAIAAGASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGISPDQVTRMITGVPWYSTRLKPAISKALSKDGIYTIAN
What are the official names of this protein?
Seripauperin-20.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DAPF_ACIBT
Sequence: MLLEFTKMHGLGNDFMVVDLISQRAYLDTATIQRLADRHFGVGFDQLLIVEPPDVPEADFKYRIFNADGSEVEQCGNGVRCFARFVHERHLTNKTNITVQTKAGIVKPELGQNGWVRVNMGYPKFLPNEIPFVADEPEALYTLELANDQNISIDVVNMGNPHAVTIVPDVLTADVAGIGPQVELHKRFPERVNAGFMQVIDDKHVRLRVFERGVGETLACGTGACAAAVSGMRRGLLANSVEVELAGGKLQIEWQEGDVVWMTGPTTHVYDGRLDLRYFQG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_RHOOB
Sequence: MARVKRAVNAQKKRRSILEASSGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGDFRKLWITRINAAARANDITYNRLIQGLRLAEIEVDRKNLAELAVSDAAAFAGLVALAKAALPADVNAPAGEAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.