PharMolix/UniProtQA huggingface dataset:
Protein: CP4F1_RAT
Sequence: MSQLSLSWLGLGPEVAFPWQTLLLFGASWILAQILTQIYAAYRNFRRLRGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSLQKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLANDPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLTAGAQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives (PubMed:10486137, PubMed:14634044).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:14634044).  May play a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:10486137, PubMed:14634044).
What are the official names of this protein?
Cytochrome P450 4F1, CYPIVF1, Cytochrome P450-A3, Leukotriene-B4 20-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: TRMFO_MAGSA
Sequence: MTRTVHVIGGGLAGSEAAWQLAQADIPVILHEMRPVRTTPAHQTDGLAELVCSNSLRSDDADYNAVGLLHEEMRRAGSLILAQADAHKVPAGGALAVDRDGFSQGVQAALAGHPRITILREEVAGLPPEDWEQVVIATGPLTSPAMAEALRGMTGEDSLAFFDAIAPIVTKDSIDFGKAWFQSRYDKGTGSDYINCPLDREQYNTFIDALITGEKVDFHEWEKDTPYFEGCLPIEVMAERGKDTLAYGPMKPVGLTNPNGPKPFAVVQLRQDNALGTLYNLVGFQTKLRHGEQARIFRAIPGLENAEFARLGGLHRNTFINGPRVLDRTLRLKAQPRLRLAGQVTGCEGYVESSAIGLLAGLFAAAEALGRDMLRPPATTALGALLNHVTGDAEAETYQPMNINFGLFPPPPERDERGRRVKGRDRKKLYAQRAREALTPWLNTIRE
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_HELPY
Sequence: MAKEKFNRTKPHVNIGTIGHVDHGKTTLSAAISAVLSLKGLAEMKDYDNIDNAPEEKERGITIATSHIEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPHIVVFLNKQDMVDDQELLELVEMEVRELLSAYEFPGDDTPIVAGSALRALEEAKAGNVGEWGEKVLKLMAEVDAYIPTPERDTEKTFLMPVEDVFSIAGRGTVVTGRIERGVVKVGDEVEIVGIRPTQKTTVTGVEMFRKELEKGEAGDNVGVLLRGTKKEEVERGMVLCKPGSITPHKKFEGEIYVLSKEEGGRHTPFFTNYRPQFYVRTTDVTGSITLPEGVEMVMPGDNVKITVELISPVALELGTKFAIREGGRTVGAGVVSNIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_GEOSE
Sequence: MAQVQYYGTGRRKSSVARVRLVPGDGRIIVNKQDIREYIPTEALIEMVKQPLVLTETLGSYDVLVNVHGGGFAGQAGAIRHGIARALLQVDPEFRTVLKRAGLLTRDARVKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9, BS10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: PCKA_PSEU2
Sequence: MTQTNNAVYTDLSTDELVKEALARKEGVLSDTGALVVETGHRTGRSPVDRFIVEEPSTQDAIAWGPINRKFPAEKFDALWNRVGAYLAERERFVSHVHVGSDPAHYLPVKMTTETAWHNLFGRCLFINPEQYNPAGKDEWEIQNAPWFVCDPERDGTNSDGTVIINFAARKVLIAGMRYAGEMKKAMFSVQNFLLPASDVLPMHCAANMGEEGDVTLFFGLSGTGKTTLSADESRYLIGDDEHGWGEGVVFNIEGGCYAKCIDLSEKNEPVIWKAIQHGAVLENVVLDPVTKKADYADSSLTQNSRAAYPRELIEKRAPKNLGGEPNAVIFLTCDLTGVLPPVSILSEEQAAYHFLSGYTALVGSTEMGSGSGIKSTFSTCFGAPFFPRPAGEYAELLIKRIRGFKSKVYLVNTGWTGGGYGVGKRFNIPTTRGVIAAIQSGALIGAETEHLDTINLDVPKSVPGVDTGLLNPRNTWADKAAYDEAAKALAGLFVENFKKFDVSDAIKAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COCA1_BOVIN
Sequence: NQPGPPGPPGPPGSAGEPGPGGRPGFPGTPGMQGPQGERGLPGEXGERGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGDSGIR
What is the function of this protein?
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
What are the official names of this protein?
Collagen alpha-1(XII) chain.
What is the protein family that this protein belongs to?
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MLXIP_HUMAN
Sequence: MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDDSDTDEPSPPPASGAATPARAHASAAPPPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLVQDDDMLYWHKHGDGWKTPVPMEEDPLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDEQGCEHTSRTEDPFIQPTDFGPSEPPLSVPQPFLPVFTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRPPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLGHGTSSPPAPVSRLFPSTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKNRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHMKDMFDEYVKTRTLQNWKFWIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDPAQLPEQASKAVTRIGKRLGES
What is the function of this protein?
Binds DNA as a heterodimer with MLX and activates transcription.  Binds to the canonical E box sequence 5'-CACGTG-3'.  Plays a role in transcriptional activation of glycolytic target genes.  Involved in glucose-responsive gene regulation.
What are the official names of this protein?
MLX-interacting protein, Class E basic helix-loop-helix protein 36, bHLHe36, Transcriptional activator MondoA.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus.
Protein: RTCA_METTH
Sequence: MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISNGTLRGDELGSMELEFSPGRVTGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGGTDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEGGGRVHAIIEPSELRPITLEESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAEGNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRTCELTLHAETNIILSEKITGRRFRVEGERGGPATIEVL
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_RHOFR
Sequence: MEEFKRNLELDRSQQHDFIYPLIFQEYIYALAHDRGLNRSIFLENTGYENKSSLLIVKRLIIHLITQMYQQNHFLFSGNDSNQNKFLGYNTNLYSQMIFEGFAVVVEIPFYLRLLSFLEGKERVKSHNLRSIHSIFPFLEDKFSHLVYVLDILISHPIHLEIVIQTLRYWVKDASSLHLLRFFLHEYPIWNSLITPKKSSFSFSIRNQRFFLFLYNFHVCEYESIFVFLRNQSSHLRSISSETFLERISFYRKIELEVFTKDFKAIIWVFKEPFLHYVRYRGKAILASKGTSLLMNKWKYYLVNFWQCYFYMWSQPRRIHINQLSNHSLDFLGYLSTVRLKPLMVRSQMIENSFIIENASKKFDTLMPITPMIRSLSKAKFCNVLGHPMSKPVWAALSDSDIIERFGRIYRNLSHYYSGSLKKMSLYRIKYILRLSCARTLARKHKSTVRAFLKRLGVGLLEEFFTEEEQVFYLTFAKASSNSGELYQRRVWYLDIICINDLANYE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y2681_SHEPC
Sequence: MESLQNHFLIAMPSLDDTFFERSVIYLCEHDDKGAMGIVINKPLGIEVSSLLEQMDLPAEQVFADIAQNAQVLMGGPVSQDRGFVLHTSQPYWANSTDLGSGLMLTTSRDVLTAIGGKRSPDKFLVALGYAGWGKHQLEQELAENSWLTIPATNALLFDVKHEDRWPQASRSLGFDAWQVSAQAGHA
What are the official names of this protein?
UPF0301 protein Sputcn32_2681.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: SYFA_YERP3
Sequence: MPHLAELVAKAKAAVEDAQDIAALDLVRVEYLGKKGHLTLQMTSLRELPAEERPAAGAVINQAKQEVQEALNARKEKLESAVLNARLAAETIDVSLPGRRMENGGLHPVTRTIERIETFFGELGFSVESGPEIEDDYHNFDALNIPAHHPARADHDTFWFDATRLLRTQTSGVQIRTMQEQQPPIRIIVPGRVYRNDYDQTHTPMFHQMEGLIVDRDISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEIYSGFAFGMGMERLTMLRYGVTDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUB3_PSE14
Sequence: MTSLKQQPPHLLRGIPLAVRNLKKAFGTREVLKDIDLHIPAGQFVAIVGRSGCGKSTLLRLLAGLDKPTEGQLLAGSAPLDDAREDTRLMFQEARLLPWKKIIDNVGLGLSGDWRAQALEALEAVGLAERANEWPAALSGGQKQRVALARALIHKPRLLLLDEPLGALDALTRIEMQQLIEKLWHQYGFTVLLVTHDVSEAVAIADRVILIEEGQIGLDLLVDLPRPRVRGSHRLAALEAEVLNRVLALPGSPPDPEPFSPLPTQLRWAN
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ADD_VIBA3
Sequence: MDFLALPKIDLHCHLDGSVRPDTIIDLAKQYNIELPEDRDAVVQSLTVPEDCKNLDEYLACFSLPLQVMQTEEAIERISFELYEDAALENVKYLEVRFAPILHVNKGLSLDTIIASAVKGMKRAEEKYDIKGNYIMSVLRMFPKDSIKDVIDAGQPYLGKGVVAFDIAGGEKPGFCAEFPEYTQYALEKGYRITVHAGEQWHGQNVYDAVTMLDAERIGHGVHIQGNEDAYNIVKEKQVALETCPTSNVQTKCIHQFSDHPIAEFKKDGIVVTINTDNRTVSNTTMTNEVKRVCETFGLTKEDYVEIYKYSVESAFASDEVKQHLMGFVEQI
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: RECO_STAEQ
Sequence: MLMKQKGIIIKSVDYGESDKIITILNEYGAKIPLMARRAKKVKSGLQANTQLFVYGLFIYNKWRGMGTLNSVDVINQHYELQLDLFESSYASLCAETIDRSMEENEVSKYNYDLLQFVLSKINEGTPAQLMSVIVLLKNMSKFGFTASFDHCAITGIQDQSKLIAYSFKFDGAISESALYQDQHAFHLSNRTLYLLNILQQLPISKMNHLNIQQDILNEMSELLIMLYREYAGMFFKSQKLINQLNRLEKDSL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: NRDI_STAAE
Sequence: MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: APC2_DICDI
Sequence: MFQNKEQTESILVWEKIVSIFSIPSQNEILNFKQKSPNNIDNNLKQLFNFVKLYKLESLVLDWYFESIKKYFKSTLSNEFWKFFNNVNLAELDSSTTSGRQLKFINHQFALSINLLHKVFSFFKSNLFLFYELLFKKESYNFNFLIKKLQDLLITNIMHTTNQQTKYFNTILFMFFERDFISFTKSFYHSKKQILKDEEENNNNSKDLEFNDQQQEEEEEEEENEEESKSYIIMEMSFEDSITDINIKEDSFMDLCKKLQDLNFIVISEEIFTQILFKKVFEYIETRCKGVFEKSFLKSILEWADQVIFKWLAMILLSSTTTTKINNYNDIINNNDDDNDDDDDDENKENSLKIFNQWKKRLEFSIYENYSQQRISELFDMIVQYPDSLPSLEDLSICFQKIPIEKTMITNLKRVLHNRLLHPGANTSDIITQYISTIHAMDIIDPSGMVMEKVGKPIREYLSQREDTIRCIISSFTEESNEIYQELCNYDPQDNGGDDDSNNSLLAFGNCDLYVDEGDNFSSIDDFKFWIPNKIDGSSTTISIGNAKANNNNKKKKKKDTISHLVNIYDGIDLFINEYRSMLSDRLLSVVDFDLDKEIKNIELLKLRFGDSVLFNCEIMIKDMVDSKRLNLQIKNSQGVNNNNNNNNNNNNELKEFETLILSQLFWPTLKGDEFKYPKSIEKKMQIYSKEYERIKTPRQLIWKQHLGLVDLDLEIGNNIQSFQVSPIHATLIMLFESDDGDDDDEKELTLEYLSKQLEISKDLVKKKLIFWLNNQIIKETSHETYKINNKEKEEQKQRQQQIENDDQDESSSDDDDDDNNIVVEEEEEEKSTSAKEKEEQMRVVESFIIGMLINFKTLPLERIHSMLTMFNSELYTSTIHELKAFLSKLVNEEKIELVGNDFKIKK
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
What are the official names of this protein?
Anaphase-promoting complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEP7_ARTBC
Sequence: MRFSVVFAAIAALSSVVTAERGCGAIPHKGFATELMEAMDNARASSFSNTTAANVTINTYFHVITDGNKGQINNDTLQKQIEVLNKDYSGTGFSFKLVGSERTNNAGWASGNDDFGMKSSLRKGGYDSLNVYFVPMLREGLLGFCHFPTKNPGKRQLIMDGCVINSNTVPGGSAQNYDEGRTTTHEVGHFMGLYHVFNDNGGGCQQDGDMVDDTPVQSKPSSGCPKGKDSCPQQGVDSIHNYMDYSYDSCLNEFSPGQIQRMQMLWKQFRAGNSNRSPKAMKPIIPSYVSDPVM
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Plays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host (By similarity).
What are the official names of this protein?
Extracellular metalloprotease ARB_07495.
What is the protein family that this protein belongs to?
Belongs to the peptidase M43B family.
What are the subcellular locations of this protein?
Secreted.
Protein: UREG_BURM7
Sequence: MNAPRFAAPARRTKKLPPLRVGIGGPVGSGKTTLLEMLCKGMRERYDLVAITNDIYTKEDQRLLTIAGALPEARIMGVETGGCPHTAIREDASINLEAVERMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLEVMASDTRKMRGERPYVMCNLKALDGVADVIAFIENKGLLTV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRR1L_DROME
Sequence: MSNSGEDFQVVTRKKWMARKCLRRRDRHKSESDYLIDCPDVNVEKFQPRLENLCTEMCQSDYFLVAMEALQQQLEGIRKPLERIVCLGLGPFSRTYHALHQAAFVIGLHRHHKIREALYFDPVFRDSEKELIRLFDGCIMSKDCAGKHEATVPTLYYLPHCPYALMHNILWSNWKRETLPNVFLISNSFEMLTMTPRNQDDHITRIVEHCTETPLEDDYEHHNVFNDLSLHTFPQESLPGSNDEAFWTRCAPLKVNEDELITETETSLAALKLESE
What is the function of this protein?
Possible regulator involved in a circadian clock input pathway.
What are the official names of this protein?
SRR1-like protein.
What is the protein family that this protein belongs to?
Belongs to the SRR1 family.
Protein: PHS_BRUME
Sequence: MARNRLTESEMNEALRALDGWQKVDGREAITRSFKFKDFSTAFGFMAQAALYAEKLDHHPEWFNAYNRVDVTLATHSENGVTELDIKMARKMNAIAG
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: PEPQ_SALPK
Sequence: MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: COX2_CHOPI
Sequence: MATWSNFNLQNSASPLMEQIIFFHDHTLVILIMITILVGYLMISLFFNSYINRFLLEGQMIELIWTILPAITLIFIALPSLRLLYLLDELNNPLITLKSIGHQWYWSYEYSDFQNIQFDSYMIPINEMKNNNFRLLDVDNRIVLPMNNQIRILVTATDVIHSWTIPSLGVKVDANPGRLNQTNFFINRPGIFYGQCSEICGANHSFMPIVIESISIKNFINWINNYS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SKY_DROME
Sequence: MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIREHFGLPGTKNFIKTWTDRQFLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGFVGI
What is the function of this protein?
GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking (PubMed:21458671, PubMed:25422373, PubMed:27669036).  Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7 (PubMed:21458671, PubMed:25422373).  This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads to increased neurotransmission and eventually neurodegeneration (PubMed:21458671, PubMed:25422373, PubMed:27669036).  Preferentially binds phosphoinositides phosphorylated at the D5 position of the inositol ring, such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:27669036).  Binding to phosphoinositides and thus membrane-association, is required for its function in regulating the turnover of synaptic-vesicle proteins (PubMed:27669036).  It is therefore likely that it is recruited to vesicle membranes with high phosphoinositide content and thereby selectively prevents endolysosomal degradation of these vesicles (PubMed:27669036).
What are the official names of this protein?
GTPase-activating protein skywalker.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Detected at the synapses of neuromuscular junction boutons, where it displays co-localization with Rab35 (PubMed:21458671). Associates with certain types of membrane phosphoinositides such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:27669036).
Protein: MCMBP_ARATH
Sequence: MGGPAYDCLTNPLGAVRFSFVNALSSGYDPASSVGKDWGVVDLFRHYFSDESAISQVPILDSSSIKWVQPKTLVRFRGMIQDMLGNEFYAGAYKDDSTWRTNKYSDVSQFPEGSSTEIQVWERRLLYCVPVPGKNQWTECSSQELKNRFLDLTGQNREKRVRVDEEMTDSMDSSTLEAGRNGSPFKKMKVGEATSSASESQVPQTSGIPPATSADSLPCLVKIYDSPESDLKLNDVVEFLGVLTFDPIVMMDTDTLDENSDALSEAESVQMPSGKVPRLHCLIHRKLETQHFLHGSSLLPEPKSPQIFKEIRESLMKYLTGLLGNDHIAAQFLLLHLLSKVHGRVDNVAVGKLSLNLIHLNKESMSIFGTQLSGALKSLLPFTQSIPLTIEYLNTASFGPKKDYGINRLMPGVLQIADGTHLILDETELQPGTLNSVGVENANLLKNLLECQKVEYDFQYYKMEMATDVQMLIFSEGKSNIMPADLVLPLQPSQVNSLEVITPETAETWRCYLATCKSLSHSIGQELQQVVENDLVAARQTDRSLGSQDLSRLLTMARMMSVSYGETTLSLEHWQMVLELERLRKERLK
What is the function of this protein?
Associated component of the MCM complex that acts as a regulator of DNA replication.  Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin.  Required for sister chromatid cohesion.
What are the official names of this protein?
Mini-chromosome maintenance complex-binding protein, MCM-BP, MCM-binding protein, Protein E2F TARGET GENE 1.
What is the protein family that this protein belongs to?
Belongs to the MCMBP family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with the replisome complex.