PharMolix/UniProtQA huggingface dataset:
Protein: PLSY_THEM4
Sequence: MEYIYSIFIGYFFGAIPFSFFIAKLKGIDIRKTGSGNVGGTNVLRNAGAFYGALAFFFDIFKAYIAVFLVKGFGIKFMLIAGTMAVLGHCYSIFLKFKGGKGVASTFGVFLAVYPWSGLVFFGVWLFIVAVTKYVSLASMIGLIFASIFVFFAGKDFWVIFLALSLFSILRHKDNIQRLINGNERKTDVIGYFFGKGKKN
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPG3_YEAST
Sequence: MICYFLVVTINFLKEKTTICHYFVNIFSLFLFLFVFVFVFIFVYFFYVILFYRFCSLFTYFPANSIWYYLSIINIFFPLCFFLYENFTGRNRRKCSLFCLTLIKITYTSPNHGFMVTGKEKFEKLRD
What is the function of this protein?
Required for survival during stationary phase.
What are the official names of this protein?
Stationary phase protein 3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: D3_CNPV
Sequence: MDIVTDKNIGSNFLADSNNRIYILIGDTDNVIDKYLVSILGKIEFYYVYEITVEDSKLINTFVTSNLLCPIKNKFNIKIYHDYKKVIGSCILNVDGKFTRYKDPSKLHVYVFCYRYNNCLNTCTMVKCHELLYPEKEIIVDGYKINDMSFFYTNPEIIKQHTDIKDYETLYKNIFLRRELNRVILGKPSDLIETLKEIVTINSEDIWKVIVSNDIFDSRDVIKLINFDYDREDFLSFVRAWYSNQLNNCKEDNNKIEKVYEIVRNSI
What is the function of this protein?
Late protein which is part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions (By similarity).
What are the official names of this protein?
27 kDa core protein.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae D3 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: RL25_CALS4
Sequence: MQAITLEAVKRETGKSAARRLKNQGYVPAIMYGKDMTENIPLAVEYTKLQKLLQKYGRNVLLNVVVNGTTHTALIKEIQEDTLKGKIIHVDFQRVSMYEEIEATVPLRFEGIGLIESKGGIVQHQLWELTVESLPDKIPQEIVVDLSHLEIGDTLFVKDIPVPEGVKVLDDPEEIVVSILVPKEAGEEEEEEGEGTAEG
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: HACL2_DANRE
Sequence: MDISMYLGCSLGAALGGVIFASYKLGLLYQLFHKTERQSPRHGGESVAEVLRSHGVKFVFTLVGGHISPILVACEKLGIRIVDTRHEATAVFAADAVARLSGTVGVAAVTAGPGLTNTVTAVKNAQMAESPLLLIGGAAATLLQGRGALQDIDQMSLFKPLCKFCASVRTVREIVPTVRKALAIAQSGTPGPVFIEFPIDTLYPYHVVEKEFAPKNTPKGLMGKIIAWYLKNHLSNLFAGAWESRDLSPLPVHIPHATDDQVQRCVELVSRAKKPVILLGSQATLPPTPADDIRKALESLGIPCFLGGMSRGLLGKNSPLHIRQNRRDALKDADLVLLAGTVCDFRLSYGRVLNRRSKIIAVNRDKSQLLKNSDMFWKPTVAIQGDAGSFLLNLSKALKGHRCPEEWPQSLKEGDNVKEKANRAKADEKTERHLNPLSVLHRVDELLAEDSIIVADGGDFVGSAAYIMRPRGPLCWLDPGAFGTLGVGGGFALGAKLCRPESEVWIVYGDGSLGYTVAEFDTFTRHKTPVIALVGNDACWSQISREQVPMLGSNVACGLAFTDYHVVADGYGGKGYLIGREDESQLEDIIKKAQKECKEGKAVLLNVLIGKTNFREGSISV
What is the function of this protein?
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.
What are the official names of this protein?
2-hydroxyacyl-CoA lyase 2, Acetolactate synthase-like protein, IlvB-like protein.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: VFR_PSEAE
Sequence: MVAITHTPKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGTR
What is the function of this protein?
Global cAMP-dependent transcriptional regulator that controls virulence gene expression by distinct cAMP-dependent and -independent mechanisms, which allow to fine tune its virulence program in response to specific host cues or environments (PubMed:20494996).  Controls the expression of many regulatory targets including type II, type III and type IV secretion systems, flagellar-mediated motility, and quorum sensing systems (PubMed:9190808, PubMed:12057955, PubMed:26929300, PubMed:30761117).  Transcriptional control is exerted by binding to a well-characterized consensus site (5'-ANWWTGNGAWNYAGWTCACAT) within target promoters (PubMed:17159200, PubMed:20494996, PubMed:26929300).  Directly binds to the toxA upstream region to regulate exotoxin A production, to the lasR gene promoter to activate the las quorum-sensing system or to the exsA promoter to regulate type III secretion system (PubMed:9190808, PubMed:12057955, PubMed:19389782).  Autoregulates as well its own expression (PubMed:20494996).
What are the official names of this protein?
cAMP-activated global transcriptional regulator Vfr.
Protein: TCP8_ARATH
Sequence: MDLSDIRNNNNDTAAVATGGGARQLVDASLSIVPRSTPPEDSTLATTSSTATATTTKRSTKDRHTKVDGRGRRIRMPALCAARVFQLTRELGHKSDGETIEWLLQQAEPAIVAATGTGTIPANFSTLSVSLRSSGSTLSAPPSKSVPLYGALGLTHHQYDEQGGGGVFAAHTSPLLGFHHQLQHHQNQNQNQDPVETIPEGENFSRKRYRSVDLSKENDDRKQNENKSLKESETSGPTAAPMWAVAPPSRSGAGNTFWMLPVPTTAGNQMESSSNNNTAAGHRAPPMWPFVNSAGGGAGGGGGAATHFMAGTGFSFPMDQYRGSPLQLGSFLAQPQPTQNLGLSMPDSNLGMLAALNSAYSRGGNANANAEQANNAVEHQEKQQQSDHDDDSREENSNSSE
What is the function of this protein?
Can specifically bind site II elements in the promoter region of PP438/PNM1.
What are the official names of this protein?
Transcription factor TCP8.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADB2_RALSO
Sequence: MTSGQSKHEIRDMKFDVLVVGEGLAALTLLLHLPPSLKIGVISRNKYDEPSSYWAQGGISAVFSTDDDHDKHIRDTLLAGDGLCDEAAVRQIVCEGGDVLRWLIDQGVPFTREDGEIHLTREGGHSERRVAHVDDMTGRGIMRALQAKVAQLPNVIWIRQYEAVELLSDGQAVSGVIAESLADGEVTVFSAPTVVLAAGGLTGLYQYATNPHASKGEAIAMAWRAGATIENLEFVQFHPTAFQIEGRVISLITEAVRGEGGLLYNVANERFMPGYSSQQELAPRDVVARAIYSEMQAHGTSHVWLDITHQGTAFVEQHFPNLVEITRAHGCDLSQHRVPVSPAAHYTCGGIGADVAGRTNIEGLYAIGEVANCGLHGANRLASNSLLECVVMGKACAQSVTDTAGSASRLRLTLPERIETPFHPNLLADLRAILWNHAGIVRSNTGLEIGLQNMAQLQERHASVLPYGQALRAQNIFDAAHLVLLSAAARKESRGGHFNKDHADKAEAQTTQIPGVPVNFWAAGENASHAAQLAAA
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase 2, LASPO 2, Quinolinate synthase B 2.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_METTL
Sequence: MSLMDPLANALNHISNCEGVGKSVAYVKPASKLIGRVLNVMQDHGYIGNFEYIEDGRAGIYKVELIGQINKCGAVKPRYAVKKQEFEKFEKRYLPAKGFGLLIVSTPKGLMTHDEAKNQGLGGRLISYVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TIG_DESRM
Sequence: MKATAERIEKNTVLLEIEVEQERVDQALNQAYKKVVKQVNVPGFRKGKAPRKMVERFVGTETLFGEAVEIIIPDAYMEALKETATEPIDQPKIDIVQGEAGKALIFKATVEVKPEVTLGEYKGLEVTKASSEVTDEDVEKELARLQDRHAKLVTLEEGEIKKDDITLIDFTGYVDGEAFEGGHAENYSLTVGSGTFIPGFEEQLLGVKLGEEKEVNVTFPEEYHAENLAGKPATFKVKINEIKRKELASLDDEFAKDVSEFDTLDELKSDIRKKLMEVAERTAKSSVENGAVEAAVEKATVEIPQAMISQKVEEMLNSMGQRLAQQGINLDQYFQYTNTSMDDMRQRMRPDAEKNVKNELVLDAIAKVENITATAEETNEEIQKIAEYVKQDAEIVRKTLELQGELGHINQDIARRKVVQFLVENAKVVEGTKED
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RIMK_PSEFS
Sequence: MKIAVLSRNPRLYSTRRLVEAGVERGHEMVVIDTLRAYMNIASHKPQIHYRGKPLEGFDAVIPRIGASVTFYGCAVLRQFEMMGVFPLNESVAIARSRDKLRSLQLLSRRGIGLPVTGFAHSPDDIPDLIDMVNGAPLVIKVLEGTQGIGVVLCETATAAESVIEAFMGLKQNIMVQEYIKEAGGADIRCFVVGDKVIAAMKRQAKPGEFRSNLHRGGSASLIKITPEERMTALRAAKVMGLSVAGVDILRSNHGPLVMEVNSSPGLEGIETTTGKNVAGIIIEHLEKNGGPNMTRTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: DCDB_LEPIC
Sequence: MILTGKEIQKRIGNDIVITPYSEKQLNPNSYNLRLHEELLVYTELPLDMKKPNPAEKLVIPESGLLLKPGILYLGRTLESTETHNLVPMLEGRSSIGRLGMLVHVTAGFGDVGFKGFWTLEISVIQPLIVYPGVEVCQIFYHTLEGQITEYTSGKYQANRGIQTSMLYKDFEK
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TRPA_STAAW
Sequence: MTKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTLNN
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: KBAZ_ECOLX
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKASALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLEDVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.  Is involved in the catabolism of N-acetylgalactosamine and D-galactosamine.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: RNFE_YERPB
Sequence: MSEAKKLLAQGLWKNNSALVQLLGLCPLLAVSSTATNALGLGLATTLVLVCTNTAVSALRRWVPSEIRIPIYVMIIASVVSTVQMLINAYAFGLYQSLGIFIPLIVTNCIVIGRAEAYAAKNPVGLSALDGFAMGMGATCALFVLGALREILGNGTLFDGADMLLGSWATVLRIDILHLDTPFLLAMLPPGAFIGLGLLLAGKYVIDEKMKARKANTRVNVPQLQDGDAEKAL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RISB_CLOBM
Sequence: MKIYEGRLTAEGLKVGIIVSRFNEFITSKLLAGSIDCLKRHGAKEDNIEVCWVPGAFEIPVIAKKMASKGKYDAVICLGAVIRGATPHFDYVSSEVSKGVAHVSLDKEVPVIFGVLTTDTIEQAIERAGTKAGNKGYDAAMSAIEMSNLMKVLD
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: AFTD_MYCTU
Sequence: MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFLARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFWGLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILALRGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWLLAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNATAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLASPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAFAHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAATPTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFGAPVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLRLDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAPGDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGDPATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTLRFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQLRHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLTVPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAWTAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQVGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAPADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALPAGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRVLVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLAIGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGTALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALISVSVVAASVVATSESRGQDRMQ
What is the function of this protein?
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
What are the official names of this protein?
Alpha-(1->3)-arabinofuranosyltransferase, Arabinofuranan 3-O-arabinosyltransferase.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DAPE_GLUOX
Sequence: MTGSTFPTDPVALARDLLRCQSVTPADGGAQALLAGVLEGMGFETFHLPFGPADVPTPNLYARLGKGHPALCFAGHTDVVPPGEGWAHDPFAAVIEGDRLYGRGIADMKGGVACFVAAVARRLEQGPLKGSVSLLITGDEEGPAHFGTKPVIEWLAERGELPDFCVLGEPTNPQALGDVIKIGRRGSMNAVVTVHGTQGHVAYPHLADNPVHRLLAAFSELTARELDAGSEWFDPSSLQVTSIDVGNGATNIIPGSAVGRLNIRFNDLHTGAALTAWIEDVVRRHAPQADVQVSISGEAFLTQPGDAVTCLSEAVRSVTGRTPRLDTGGGTSDARFISQYCEVAEFGLVGATMHKRDENVELGTLEDLTRIYLAFMEGYGL
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ILVC_PSEAE
Sequence: MRVFYDKDCDLSIIQGKKVAIIGYGSQGHAHACNLKDSGVDVTVGLRSGSATVAKAEAHGLKVADVKTAVAAADVVMILTPDEFQGRLYKEEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYACGVGGGRTGIIETTFKDETETDLFGEQAVLCGGCVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINAESRAAMRNALKRIQDGEYAKMFITEGAANYPSMTAYRRNNAAHPIEQIGEKLRAMMPWIAANKIVDKSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MINC_AQUAE
Sequence: MIEIKGKTLPVIQIKIKEKGNIDKLLKELKEKLSHNIFKGSLIILENPEVLKPEERKKVEEILKEFSRGFIEGKKEGKEKREESRLLIIERTLRAGQRIEHRGDILILGDVNKDAEVLAGGNIIVMGKLRGVAKAGLIGDHSAVIVALKMEPQLLQIGKKKAIMSEADRNSPGYPEVAKIEGEDIVLEPIEGAERWLKLLL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization (By similarity).
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: GLYA_ECOL6
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_STAAC
Sequence: MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRFQEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQIHNIFEFGTDHGAVLVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGHLNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAVWLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLAEEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLIETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_SYNEL
Sequence: MKHFFKSLTLAIALAASVLFWSPQAQAYPFYAQQGYESPREATGRIVCANCHLAAKPIQVEVPQAVTPDSVFEAVVKIPYDTSVQQVLGDGSKGGLNVGAVLMLPEGFKIAPPDRLPEELQAKTSGIYYQPYSDDQQNIILVGPLPGEQYQEIVFPILAPNPGTDKSIHFGKYAVHAGGNRGRGQVYPNGEKSNNNVFTAPIAGTITSITPNPDGSTAVVITPENGEAVTETVPAGPELIVREGQTVVAGAALTNNPNVGGFGQKDTEIVLQDPNRIKWLLVFFAAITLSQILLVLKKKQVEKVQAAEMSF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS13_SHEDO
Sequence: MARIAGINIPDQKHTVIALTAIFGIGRTRARAICASTAIAETAKIKELSEAQIDILREEVAKYSVEGDLRREISMNIKRLMDLGCYRGLRHRRSLPLRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: COX2_UROCA
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAAILVLIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNELKPGDLRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGANHSFMPIVLEMVPLKHFENWSASMV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURE_TRIV2
Sequence: MKLRELLATVDSVENLPPVLADTEVKGIKTNSHACGAGDLFIGMPGTRVDGGEFWPSAIASGAIAAIVSPQAVEKNPPSDEAVVISSNNMTKACAAIAAAFYGYPGQKLKLVGVTGTNGKTTTTHLIEFFLTKAQLSTALMGTLYTRWPGFEQTATHTTPFAVELQQQLAQAVNAGCEFGVMEVSSHALAQGRVLGCPFEVGVFSNLTQDHLDYHSDMEDYFAAKALLFSPDYLKGRAIINADDTYGQRLIKALSPEKVWSYSVNDSSADLWMSDLSYEPNGVTGTIHTPEGDVSFRSPLVGQYNLENLLASVGAVLHLGLDLQLIANAIPEFPGVPGRMERVQINPDQDISVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDRTKRPKMGKIAAELADLAFVTSDNPRTEDPEKILDDILAGIPDTVQPTVIGDRAIAIRTAILQAQPGDGVLLAGKGHEDYQILGTEKIHFDDREHARAALTEREKL
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.