PharMolix/UniProtQA huggingface dataset:
Protein: BOR4_ARATH
Sequence: MEEERVDSSKRLFRGIVADLRGRALCYKEDWVAGLRSGFGILAPTTYIFFASALPVIAFGEQLSRDTEGALSTVETLASTALCGVIHSILGGQPLLILGVAEPTVLMYVYLYNFAIGRPELGKQLYLAWAAWVCVWTALLLFVMAILNTADIINRFTRVAGELFGMLISVLFIQQAIKGMVSEFGMPKDEDSKLEKYKFEWLYTNGLLGLIFTFGLLYTALKSRKARSWRYGTGWYRSFIADYGVPLMVVVWTALSFSTPSKLPSGVPRRLFSPLPWDSPSLSHWTVIKDMGKVSPGYIFAAFIPALMIAGLYFFDHSVASQLAQQKEFNLKKPSAYHYDILLLGFMTLICGLLGLPPSNGVLPQSPMHTKSLAVLKRQLIRRKMVKTAKESIRKRETSSQVYENMQEVFIEMDKSPLAQTDPSVIIELQDLKEAVMKSNDEEREGDEESGFDPEKHLDAYLPVRVNEQRVSNLLQSLLVAGAVLAMPAIKLIPTSILWGYFAYMAIDSLPGNQFFERLTLLFVPTSRRFKVLEGAHASFVEKVPYKSMAAFTLLQIFYFGLCYGVTWIPVAGIMFPVPFFLLIAIRQYILPKLFNPAHLRELDAAEYEEIPGTPRNPLELSFRSNDSKRGVQEGDAEILDELTTSRGELKVRTLNLNEDKGNQIYPKEKVKAGDGDMSTTRE
What is the function of this protein?
Efflux-type boron transporter polarly localized in roots.  Boron is essential for maintaining the integrity of plants cell walls.
What are the official names of this protein?
Boron transporter 4.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31.3) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: MUTL_RICTY
Sequence: MTIKFLSESTINRIAAGEVIERPASVVKELVENAVDGGSTKIDIILERAGKNLIIVSDDGIGMTDKELEIAVERHTTSKLNESDFLNIHTFGFRGEALPSIAAISKMLITSKKREADKAFQIKLIGGNKQQITVSVHNEGTKIEIRDLFFATPARLKFLKSDRTELAASLDIVKKIALAHPKISFNLIHNSKNLLKLKGQNKDFETNLKQRIIDVIGDVFIKNASYINFKTPDFSICGYTSIPTYSRASSEDQFLFINNRPIKDKLLQVALRVAYQDYLARDRYALCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNILIEAIKNALTNKSQVTVTTTDAIELFKNPLVNKQPPINKAINVNSKASEYISFNFNRNTVCQKLTLQSDKIEQEVGKCIEHDNQSYKQYKFGIAKAQLHTTYIISQTEDSIVIIDQHAVYERLGYEKIKYCLKNGELVKQRLLIPEIVELSSGEKADYLYENRDKLFKLSLTIEKFGEKSIIVTEVPNLLRDVNVQKLIQDLADHLSDFSKNIALKELIEHVIKIYICHYSIRAVRKLSVDEMNSLLRQMENMSFSAQCNHNRPTYIELKLKDIERLFRL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: HCBT1_DIACA
Sequence: MSIQIKQSTMVRPAEETPNKSLWLSNIDMILRTPYSHTGAVLIYKQPDNNEDNIHPSSSMYFDANILIEALSKALVPFYPMAGRLKINGDRYEIDCNAEGALFVEAESSHVLEDFGDFRPNDELHRVMVPTCDYSKGISSFPLLMVQLTRFRCGGVSIGFAQHHHVCDGMAHFEFNNSWARIAKGLLPALEPVHDRYLHLRPRNPPQIKYSHSQFEPFVPSLPNELLDGKTNKSQTLFILSREQINTLKQKLDLSNNTTRLSTYEVVAAHVWRSVSKARGLSDHEEIKLIMPVDGRSRINNPSLPKGYCGNVVFLAVCTATVGDLSCNPLTDTAGKVQEALKGLDDDYLRSAIDHTESKPGLPVPYMGSPEKTLYPNVLVNSWGRIPYQAMDFGWGSPTFFGISNIFYDGQCFLIPSRDGDGSMTLAINLFSSHLSRFKKYFYDF
What is the function of this protein?
Catalyzes the formation of N-benzoylanthranilate, in the course of methoxydianthramide B, a phytoalexin.  Phytoalexins are produced in response to infection by parasites, and are essential for the expression of disease resistance.
What are the official names of this protein?
Anthranilate N-benzoyltransferase protein 1, Anthranilate N-hydroxycinnamoyl/benzoyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: RS17_STRP4
Sequence: MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKKYKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PX11B_PONAB
Sequence: MDAWVRFSAQSQARERLCRAAQYACSLLGHVLQRHGASPELQKQIRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPGGHLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP
What is the function of this protein?
Involved in peroxisomal proliferation.  May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane.  Promotes membrane protrusion and elongation on the peroxisomal surface.
What are the official names of this protein?
Peroxisomal membrane protein 11B, Peroxin-11B, Peroxisomal biogenesis factor 11B, Protein PEX11 homolog beta, PEX11-beta.
What is the protein family that this protein belongs to?
Belongs to the peroxin-11 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: EX7L_DESAP
Sequence: MAREMRIVSVRELTGYIKERLESDPFLAHVWVRGEVSACTRHPSGHLYFFLKDEAARIRVVMFRSQVSRLGVPLENGTTVVVRGYLGVYERNGEYQLYAQGAEAEGAGKLHAALERLKEKLQREGLFDPARKRALPALPDTVGVVTSPVGAALKDILTIMRRRWPPARVLLAPVSVQGETAPYEIAQAIRALNGAGGVDVIIVGRGGGAPEELAAFNTEVVARAIFESRIPVVSAVGHEKDVTVADLVADWRAPTPSAAAEAVVPDQRAVRERLAAVESRLGRAVRHRLAVYRVRLEALRQRPVMASPGVLCRRRREVVRSLEERLGGAIGRRTGEGRSRLAVLSGRLEALSPLQVLARGYSICRRADGRIVRDADGVSPGERVIIWLHAGGLSCLVEETFPSRNP
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTH_ENT38
Sequence: MSRVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQFVQQGLGVFGGAIADRFGAKPMIVTGMLLRAAGFATMGIAHDPWLLWFSCFLSGLGGTLFDPPRTALVVKLIRPRQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAALFILCAAFNAWLLPAWKLSTVKAPVREGLGRVMADKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMTLSMMPIGLVSSVQQLFVLICTFYIGSIIAEPARETLGAGLADPRARGSYMGFSRLGLALGGALGYAGGGWLFDSGKAMNQSELPWVMLGVVGFITLIALWWQFSPKRSASGMLEPGA
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENGB_SHESA
Sequence: MTESHIDFRRAKFLISAPDIAHLDQYLPGDVGVEIAFAGRSNAGKSSALNALTEQKNLARTSKTPGRTQLINVFELDAQRRLVDLPGYGFAQVPLAMKLKWQQSLGEYLQKRACLSGVVVLMDIRHPLKDLDMQMIEWAVASEIPVLALLTKSDKLAQSAKMKTVNEVRKALVEFGDWVQVEPFSALKGTGKPKVLSILNEWCHPQWLADELENQDDAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: Y236_MYCPN
Sequence: MDKLINKPQPLTSDISTSGFIYFAVVFVAIMGYLLFKNLLFLFFFKRYPKNTPKIGVGNITTIAMIIAVAVSIVLVLMALAGGLAAALFRGYPGFRVTLELILVKISGLLFGPIVGIFSAATIDFLTVIFSGGVFNVGYVLGAILTGMIAGILREVLISTALLHNRNLSDFAYLVLSIGMVIAAFLITQFFVLGISNNLKEIKGDEEFRLKFNAPSIVFELSLTQYANILLYFTIAIVIAMLVLYIVWLVKQRHLSFEHSRFFYRSYKHANHQFTLFVLTKENWFYLILNVITLASTSLLMINIAFIPIFDTQTTGQTYEFWLLARLLFAPVIFLLDIIVIYPILLLLTPLMLKGFKTAVSKNQRKTLKQSFTDLQSVVLPIINKRKHQQLRQEELKRLARATHFDLTEGEMEKLLVEFKTITQSFDRVMNIDTTSVEPMYAPFNTSPTPLRKDKVIVEKHPEKLLANCKEMSVGFVKV
What are the official names of this protein?
Uncharacterized protein MG098 homolog.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GatC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KGUA_GEOMG
Sequence: MKREGVLYIISAPSGAGKTTLCKEIIDIFPHLRHSVSYTTRQPRAGEVHGKDYYFISMDEFRSMVDKGEFAEWAEVHGNCYGTSIRTLEECRITGIDLILDIDIQGARQLKERYEGGVYIFILPPSYEELRRRLNGRSSDSDDVISRRIDAAAGEIRESRWYDYIIVNDQFSRAVEELKSVVVAERCRTFRVLETVTERFDMG
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP6_YEAST
Sequence: MERPSFLDQEPPAGYVPGIGRGATGFSTKEKQVVSNDDKGRRIPKRYRENLNNHLQSQPKDDEDDEAANVFKTLELKLAQKKKKRANEKDDDNSVDSSNVKRQFADLKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGNVDLNKLTEEREKLLQSQIDENLAQLTKNASNPIQVNKPNAATDALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKLAVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFRKILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNSNLTCQAIVYAILEWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPCDTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDTRQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKKCSRYGDTWVWLFRTYARLGKDTVDLYNMFDQCEPTYGPEWIAASKNVKMQYCTPREILLRLMNDK
What is the function of this protein?
Participates in pre-mRNA splicing.  Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: YRRC_CAEEL
Sequence: MGSTYSEWNQRATLWLQSKMGRRARIGLLAATVVGYPIGSILINGPFVNFTFPKRYSVEPLPEHLVPIADQEYGRFLDRESRIPKDAVVSVQIQRSMTNSDETVASGSLGVRTGLNLAVPMYSRFKNAQEALDYFKSQNPEGMDFLGERVPIRWDSEIAEEFTDCYAFSDNAHHFLFLRDLYAYDGYASLAQRSISWATWTTFSSIFTYWIHNSSRIMGGSAASFAIAYPILLGAAWYANKQWHLLYRYLTDIHADAEAARASFEHAEGGKEYYWKMLKRNRIMRDIKPSLWNQITATGDIRGIATPIITRYDHLKDVNEEDDELKAVIGMDD
What are the official names of this protein?
Uncharacterized protein R144.12.
Protein: CTNS_ARATH
Sequence: MASWNSIPLEISYEIVGWIAFASWSISFYPQLILNFRRRSVVGLNFDFVMLNLTKHSSYMIYNVCLYFSPVIQKQYFDTYGDKEMIPVAANDVAFSIHAVVMTAVTLFQIFIYERGPQKVSRLAIGIVVVVWGFAAICFFIALPTHSWLWLISIFNSIQVFMTCVKYIPQAKMNFTRKSTVGWSIGNILLDFTGGLANYLQMVIQSIDQNSWKNFYGNMGKTLLSLISIFFDILFMFQHYVLYPEKKVSKSPETGEESNEPLIDSSHEHV
What is the function of this protein?
Thought to transport cystine out of lysosomes.
What are the official names of this protein?
Cystinosin homolog.
What is the protein family that this protein belongs to?
Belongs to the cystinosin (TC 2.A.43.1) family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: REGB_CERSP
Sequence: MILGPDGILNRDTRGDWWRLRTLILLRWMAVAGQLAAIVVTDWYLGVRLPMGLCFMAVGASVIANVIATFVFPQNRRLTEFQALMILLFDLTQLSFLLFLTGGLTNPFALLILAPVTISGVALDVRTTVILGAIAIGLLTFTAYFHLPLILADGSSLSVPRMFEFGFWLAIVIGILFLGLYSRRVAIEIRSMSDALLATQMALDREQKLTDLGGVVAAAAHELGTPLATIKLVSSELAEELSEQPALRDDADVIREQADRCRDILRSMGRAGKDDLQMRQGPLGEVLREAAEPHVGRGKRVEFDLYPSRGGDERQPVILRRPEVIHGVRNLIQNAVDFARSTVWIDGEWTGDRIAIRIVDDGEGYPPAIIGRIGDPFVRQRRAEESQSRRPGYEGMGLGLFIAKTLLERSGAELSFANAADPFLRSHERPERCGAIVEVIWPVDRLVVVRNAPLGENVLIQT
What is the function of this protein?
Member of the two-component regulatory system RegB/RegA.  Involved in the positive regulation of photosynthesis gene expression in response to anaerobiosis.  Also involved in positive regulation of the cbbI and cbbII Calvin cycle CO2 fixation operons, as well as in regulation of expression of genes involved in alternative CO2 fixation pathways.  Phosphorylates RegA/PrrA.
What are the official names of this protein?
Sensor histidine kinase RegB, Protein PrrB.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNH2_RICAE
Sequence: MEVDLLHFEKKYHNCIVAGIDEAGRGPLAGPVVASAVIVDNANIITGIKDSKKLSKKKRELLYEQITSNYVWATAIISHTEIDDINILEATKKACSIAVANLSLEPEIVLVDGNMQFKDERFVSIINGDNLSLSIAAASIVAKVTRDRLMLDLSAEFPQYLWHKNSGYGTKEHIEAINIYGLSPYHRRSFRCC
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMP2_SCHPO
Sequence: MSQQLSFNASSAKPDKSFSNYFWGANDEGYHALLSRFSDVKHINEELRSFYHERANIEEDYAKRMAKLSRTTFSSLETGCLKESVQVMKAEVDNMAKSHLQISQLLQDDVENAFTRYAASLKDKKKMIVSGIEKVHKDKLSKHQALVKAQDKYHYLCKKVNYYVSQQNMLFGKELEKNNAKLNKTQNAITASSSDYQSAVAAVRDSYARWTNEWRSTCDKLQDIEEERRHFLKSVMWTFTLLISRSCFNDDQACERIRKNLEQCSVSQDVLEFIDAKSTGTGIPQPPKFYDYYKGEVPDDSVELVQANFQRAQTKIENDNMPLNRPYVLSATARNESSFENTLPNTPSAIQSLTTVSSNSSQNGRSSPKKSFLSKFKLTSRPSTPNVGNTAPDALSSPRNDSPLTSAADEQMKHLSLQEEPKQNPTPAAPGAFPNSNTLPPRYNELGSLPSPNSVSFTEDSRPNVNTPSRRQQIQEEFGSVLQMENRAVSPVYDSRKNGSRSSFTLRKSRSPKRPSSSLSQNASRLPRSLTPGNLEPNYDFGVRVDPASGTAPTDDEPYTDRDSSFVDDTINTKATGNTSNRLSLPAYPTDGGDTSIDNPTSTDGQRILGYVSALYDYDAAIPEEISFRKGDTIAVLKLYEDGWWEGFVVGEDDHNRGQFPSNFVREIEV
What is the function of this protein?
Required for normal septation.  Involved in the disassembly of the medial ring during septation.
What are the official names of this protein?
Septation protein imp2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associates with the medial ring during septation.
Protein: RS21_ERWT9
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: SLX1_BOVIN
Sequence: MGPGCFFGVYLLYCLNPRHRGRVYVGFTVNPARRVQQHNGGRKKGGAWRTSGRGPWEMVLIVHGFPSAVAALRFEWAWQHPQASRRLTHVGRRLRGEATFAFHLRVLAHMLRAPPWVRLPLTLRWLRADFRQDLCPPPPPHMPLAFGPPPPRAPPPRSQAGPSDDMGFEPQQDVDVRCTLCARALQDEESPLCCPHPGCSLRAHVICLAEEFLQEEPGQLLPLEGACPGCKNSLLWGDLIWLCRMGTEEDEEDSELEEEHWTDMLKT
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.  Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs).  Resolves HJs by generating two pairs of ligatable, nicked duplex products.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1, GIY-YIG domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAN_SULIA
Sequence: MSGDFDTIRDASSSDEVQLVRLLEEKIKSLQIEIENLRKELNYYKAEMEKMLSPPLIEAVVLDVLPDGRVLVRSSSGPNLVVNVASHIDQKLIKPGVSVALNQRGSTILEVLPQKEDPIVKTMEIVEKPNVTYSEIGGLEEQIKELREVVELPLKKPEIFREIGVEPPKGVLLYGPPGTGKTMLAKAVATESNAVFIHVVASEFAQKFVGEGARIVRELFEMAKRKAPSIIFIDEIDAIGAKRIDIGTSGEREIQRTLMQLLAELDGFNPLDNVKIIAATNRIDILDPALLRPGRFDRIIEVPLPDFRGRTEIFNIYLKKMKVEDNINLELLSQLSEGFSGADIKNVCVEAAYMAIRDGRNKVTMKDLVDAITKINVKRNNMESMKERREKYS
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_THESQ
Sequence: MRIVFVGTPEFAAEILEHLIKNGFNVVGVVTQPDKPRGRGRKVEPTPVKVVAEKHRVPFIQPESINKKEALEFLRSVGPDVIIVASYGKILGEKVLSLPSLGCYNIHPSLLPKYRGASPIQRVLENGEERTGVTIYKMVRELDAGPIALQREISIDPFETFDQLEKRLIELSKEMSIEFLEKLKVGDIELKEQDHSRATYAPMIKKEDLIVDFSKDAESVKNKIRAYDSRPGARAFLGNDEVKLFGVTAIDSSGDEPGLIHYIDREGAWIGTGKGMVKVKYLQLPGKKKLTFWELRNGRLIEEGMKLEGRYES
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SSRP_ONYPE
Sequence: MKTIITNKKAFYDYSLEKKKYQAGIKLLGSEVKSIRIGKINLLNSYIHIKNEEAFIVNMTILKYPFSCCLAYDENRTKKLLLQKHEIIQIKNKIKTEKLSVIPLKVYFNKNLVKLEIALSKGKKQHDKRNALKDFDAKLRIQKTLKNFNQKQ
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LPXK_DINSH
Sequence: MRPPGFWHAPPDALGWRARALAPLGALYAAATARRVARPPAHRPGIPVICVGNINAGGTGKTPTVIALQMILAARGIAAHVVSRGYGGRLEGPVAVDPRRHDAAEVGDEPLLLAAFGPTWVARDRAAGARAAEGAGAQAILLDDGFQNPTLAKDLSLVVVDAQRGFGNGRVIPAGPLREPVARGLARADLLLTIGPPAAQARFDALWGPATVTLPHLRGALTPLQTGMRWEGLRAVAFAGIGHPQKFFDTLQDQGVILCATHPLDDHQPLDARLITRLLADAKAQGAQLVTTEKDAVRLPAELRGQVLSLPVRLALADDTALTAALDTLFPNATRRL
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: GASR_MOUSE
Sequence: MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
What is the function of this protein?
Receptor for gastrin and cholecystokinin.  The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity.  This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PA_I80A6
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETVEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIIKPHERGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLKQYDSDEPETRSLASWIQSEFNKACELTDSSWIELDEIGEDIAPIEHIASIRRNYFTAEVSHCRATEYIMKGVDINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: UVRB_MYCLE
Sequence: MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELRGMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVELAVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITDSMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFEGRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.