PharMolix/UniProtQA huggingface dataset:
Protein: PYRG2_BOVIN
Sequence: MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAMVPVDGHKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVPVLLEEQGIIKYFKERLDLPIGDSASSLLSKWRNMADRYERLQKTCSIALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEQTTEVEDPVKFHEAWQKLCKADGVLVPGGFGIRGTLGKLQAISWARSRKIPFLGVCLGMQLAVIEFARNCLNLKDADSTEFEPNARVPVVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRYEVNPSLISQLEQKDLSFVGQDVDGERMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLLQGCKLSSSDRYSDASDDSFSEPRLAELEIS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).
What are the official names of this protein?
CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SYGB_RICFE
Sequence: MSELLLELFSEEIPAFMQKNAEEGYLNIFTKIFEENEIFAKVQAFAGPRRITLYATHLPKVTLPKETEIKGPSIDAPEAAINGFCKAHNVSKLELSTKLINNQLYYFFVKKTEEREIKEILPEIIIEAINKYSWAKSMFWGDYKIKWIRPLRNILCIFDGEVLPLQFGHLTANNIAYGHRYRLTDNKKLEVTDFEDYKNKLSENHVILERTKREEIIKTGLLELANSRNLNIKEDNRLIEEVAGLSEFPVVLLGKIPQKFLELPKEVLISSMRTHQKYFCLFDKEGNFAQYFLFVSNGRFANAELVIKGNEKVLSARLSDALYFYKQDIAKTLESRLGKLEAVTFHAKLGNLREKVERVAKICSYTALDNTDLITAAKLCKSDLVSEMVGEFPDLQGIMGYYYAKHEGLGEEVAAAIKDHYKPQGLSDNVPGGNAALLALADKVDSLVGLMIAGEAPTGSGDPYALRRQALGIIRIILENKLELNLNDLIIFSLKLYGNSADKDLITSFFEERAKFYFKNDYDIALINAALDLNLVDTKFKLDSLKEFLVEDAGKQLLNAYKRASNIIDGQKITGLVDASLFSTQPEKELFEVMQKISPQVTSSISDKDYNKALNLLSFLLTPITSFFDNVLVNDPDPKIAENRLSLLHNICELFDKVAKFCRL
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSMB1_PROFL
Sequence: MRVFFSLIIFSFTLATCQGVCAPRPEHIDGEVATRICVDPNDRRKHLVVSKWNTAGCTICECFKGGLRCCLRHDAIPFRDGCESVLNQVTCEYEFYRLDDLSKRCDA
What is the function of this protein?
Shows an inhibitory effect toward the metalloproteinase brevilysin H6, but does not inhibit the metalloproteinases thermolysin, HR1A and HR1B.
What are the official names of this protein?
Small serum protein 1, SSP-1.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMF_SALA4
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQSFRRQVLWFTTLVSRGENLPPLYRALAEAGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDI_ECOL6
Sequence: MSQLVYFSSSSENTQRFIERLGLPAVRIPLNERERIQVDEPYILIVPSYGGGGTAGAVPRQVIRFLNDEHNRALLRGVIASGNRNFGEAYGRAGDVIARKCGVPWLYRFELMGTQSDIENVRKGVTEFWQRQPQNA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: RSMA_UREU1
Sequence: MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPGWGAITELLVQKTDTLVAIELDKRLYAHLKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAKVNTRGYNAFTVLVQLFCKTKILFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIYDIKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_AETGR
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: XYNA_THENE
Sequence: MRKKRRGFLNASTAVLVGILAGFLGVVLAATGALGFAVRESLLLKQFLFLSFEGNTDGASPFGKDVVVTASQDVAADGEYSLKVENRTSVWDGVEIDLTGKVNTGTDYLLSFHVYQTSDSPQLFSVLARTEDEKGERYKILADKVVVPNYWKEILVPFSPTFEGTPAKFSLIITSPKKTDFVFYVDNVQVLTPKEAGPKVVYETSFEKGIGDWQPRGSDVKISISPKVAHSGKKSLFVSNRQKGWHGAQISLKGILKTGKTYAFEAWVYQESGQDQTIIMTMQRKYSSDSSTKYEWIKAATVPSGQWVQLSGTYTIPAGVTVEDLTLYFESQNPTLEFYVDDVKVVDTTSAEIKLEMNPEEEIPALKDVLKDYFRVGVALPSKVFINQKDIALISKHSNSSTAENEMKPDSLLAGIENGKLKFRFETADKYIEFAQQNGMVVRGHTLVWHNQTPEWFFKDENGNLLSKEEMTERLREYIHTVVGHFKGKVYAWDVVNEAVDPNQPDGLRRSTWYQIMGPDYIELAFKFAREADPNAKLFYNDYNTFEPKKRDIIYNLVKSLKEKGLIDGIGMQCHISLATDIRQIEEAIKKFSTIPGIEIHITELDISVYRDSTSNYSEAPRTALIEQAHKMAQLFKIFKKYSNVITNVTFWGLKDDYSWRATRRNDWPLIFDKDYQAKLAYWAIVAPEVLPPLPKESKISEGEAVVVGMMDDSYMMSKPIEIYDEEGNVKATIRAIWKDSTIYVYGEVQDATKKPAEDGVAIFINPNNERTPYLQPDDTYVVLWTNWKSEVNREDVEVKKFVGPGFRRYSFEMSITIPGVEFKKDSYIGFDVAVIDDGKWYSWSDTTNSQKTNTMNYGTLKLEGVMVATAKYGTPVIDGEIDDIWNTTEEIETKSVAMGSLEKNATAKVRVLWDEENLYVLAIVKDPVLNKDNSNPWEQDSVEIFIDENNHKTGYYEDDDAQFRVNYMNEQSFGTGASAARFKTAVKLIEGGYIVEAAIKWKTIKPSPNTVIGFNVQVNDANEKGQRVGIISWSDPTNNSWRDPSKFGNLRLIK
What are the official names of this protein?
Endo-1,4-beta-xylanase A, Xylanase A, 1,4-beta-D-xylan xylanohydrolase A, Endoxylanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
Protein: RS19_BART1
Sequence: MVRSVWKGPFVDGYLLGKAEKVRASGRNEVIKIWSRRSTILPQFVGLTFGVYNGNKHIPVSVSEEMVGHKFGEFAPTRTYYGHGADKKAKRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: YNFB_ECOL5
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQRAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVIIP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: TRPB_PYRAR
Sequence: MVDRWYNIAADLPAVLAPPKDPDEGESRIGLLTRILPSALIDQEFSAERWITVPEEVRDAYRRVGRPTPLLRAEGLERALGTGVRIYYKYEGVLPVGSHKLNTALAQAYYAKADGAVEVATETGAGQWGMAVSLAAALFGLKAVVFMTRSSYNSKRQRLTFMRTYGATVYPSPSEVTEAGRRHYRPDHPGSLGIAISEAVEYVLSGEKRHYLPGSVLEFVLMHQTVIGLEAVRQLPEEPDAAVACVGGGSNFAGFTYPMIGMKLRGEGFDKTRFVAVEAEAAPKLTKGEYKYDFPDAVGILPMIKMYTLGHDYVPPPVHAAGLRYHGAAPSLSLLRKLGIVEPLSYPQEEVMKAAVLFARTEGIVPAPESAHAIRAVLDLAKKLPRGSVIAFNLSGHGLLDSDAYEKFL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CVP7_PIMHY
Sequence: MSKVFVIILVALMVAISIASAHRPPPNPRCLPGHSKCKYEPKKNSCCLGFQCTERNQCELVYPGHHGKPCGKDNLLGCILPPPTFKPRPCGKYNLKGCKPIRPRPHPHH
What are the official names of this protein?
Cysteine-rich venom protein 7, cvp7.
Protein: LOLB_YERE8
Sequence: MPQRKISFYRLLPLATLLLAACSTTPPSGPATSPTSPQWRQHEQQLRQLSQFQTRGAFAYLSEKQKVYARFFWQQTAPERYRLLLTNPLGSTELELVVQPGVTQLTDNQGKRHVSNDPQEMIQKLTGMSIPLESLRQWILGLPGDTTDFTLDDKYRLKQLTYQQDGVTWVVDYQEYNTQVTPALPSRMELSQGGQRIKLKMDNWTVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: NUOK_PHEZH
Sequence: MTIGLAHYLAVAAILFTIGVFGIFVNRKNIIVILMSIELILLAVNINLVAFSVYLGDVVGQIFAMFVLTVAAAEAAVGLAILVTFFRNRGDISVDDASMMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYSG2_SERP5
Sequence: MDYLPIFCQLQHKACLLVGGGEIAERKARLLLDAGAALTVNACSFTPQFHEWAALGRLTLAAGEFSAELLAEKWLVIAATDRVEVNALVYQCANQQRVFCNVVDDPKRASFIMPSIIDRSPIMVAVSSGGKAPVLARLLREKLEAVLPQHLGKLAQLGGSLRQRVKKHFSDIGSRRRFWEKLFAHDRLAQSLANNDVALAERQIEQLFSHQPQECGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDEIMTLVRRDAERIFVGKRAGHHCVPQEQINQILLQQAQLGKRVVRLKGGDPFIFGRGGEELETLADANIPFSVVPGITAASGCSAYSGIPLTHRDHAQSVRLVTGHAKSDGGLDWSTLAAGQQTLVFYMGLTQAADIQRQLIAHGMPAATPVALVENGTSCRQRVIEGELSQLGTLALQAASPSLIIVGSVVSLRSKLNWFSSQEPSQPLAQMA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: CU054_HUMAN
Sequence: MLAKGAEEGRSGGPRPAITLPGSLHFTCDLKTSPYCLTRAELMEHLPLRVAVHSMSPCHRSCFCGELKRGHPWNTPQVSSFPSSTTSLSHSCTTSHLDCSQQVESGSK
What are the official names of this protein?
Uncharacterized protein encoded by LINC01548.
Protein: CYSD_PSESM
Sequence: MVDKLTHLKQLEAESIHIIREVAAEFDNPVMLYSIGKDSAVMLHLARKAFFPGKLPFPVMHVDTRWKFQEMYRFRDQMVEEMGLDLITHINPDGVAQGINPFTHGSAKHTDIMKTEGLKQALDKHGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNVYNGNVNKGESIRVFPLSNWTELDIWQYIYLEGIPIVPLYFAAERDVIEKNGTLIMIDDERILEHLTDEEKSRIVKKKVRFRTLGCYPLTGAVESEATSLTDIIQEMLLTRTSERQGRVIDHDGAGSMEEKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: LFTR_RHORT
Sequence: MISITPEILVRAYASGVFPMARAHDDPQLYWIDPDERGVLPLDGLHVSRSLRKVLRHCPFTVTIDTVFVEVLKQCAAPVPGRDETWINAEIEHLFTDLFDLGLGHSVECWQGDQLVGGLYGLAMGGVFFGESMFSRVDNASKVALCHLVARLKRGGFRLLDTQFTTNHLRSMGAVEIARPLYHARLGNALQVMGDFTVDVPDVLAALDTPSGY
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAA_KLEP7
Sequence: MTIFDNYEVWFVIGSQHLYGPEALRQVTKHAEHVVNSLNAEAKLPCKLVLKPLGTTPDEITHICRDANYDDKCAGLVVWLHTFSPAKMWINGLTILNKPLLQFHTQYNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHSVVTGHWQDKEAHQRIGGWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDISALVDEYESSYRLTPAAQVHGDKRQNVLDAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFDNGNDLVLGSHMLEVCPTIATAEKPILDVQPLGIGGKADPARLIFNTQTGPAIVASLIDLGDRFRLLVNTIETVPTPHDLPKLPVANALWKAQPDLRTASEAWIIAGGAHHTVFSHALNLDDMRQFAELHDIELTVIDNDTRLPSFKDALRWNEVYYGSKR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: AROB_XANOP
Sequence: MTLPRSSRSVAVDGAQPYTITIAPGLLADDARLARHVRGRHALLLSDSQVAPHYAAGVRAALLSARPDLQIGELVIAAGEASKTLDTFGSAITALAELGATRDACVFALGGGVVGDLAGFAAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNLVGAFHPPRAVLADTDTLRTLPARELRAGLAEVIKYGAIRDPLFFQWLHAERHALLDSDPAALAQAIARSCEHKAEIVARDPLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSATLGMSDAQDTEALRALLHDFELPTDIPPGLPPEALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVEEAAVLKILAG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_HUMAN
Sequence: MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:23636399).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
40S ribosomal protein S9, Small ribosomal subunit protein uS4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: ATPG_STRE4
Sequence: MAGSLSEIKAKIISTEKTSKITSAMRMVSSAKLVKSEQAARDFQIYASKIRQITTDLLKSDLTTGSDNPMLVSRPVKKTGYIVITSDKGLVGGYNSKILKSIMDMIQEYHAAGDYEIISIGSIGSDFFKARGMNVAFELRGLADQPSFDQVGRIISQSVGMFVNEIFDELYVCYNHHVNSLTSQVRVQRMLPISDLVAEEAAEEGVTGFELEPNRHVILEQLLPQFTESLIYGAIIDAKTAEHAAGMTAMQTATDNAKHVINDLTIQYNRARQAAITQEITEIVAGANALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: IL6_LAMGL
Sequence: MNSLSTSTFSPVAFSLGLLLVMATAFPTPVPLGEDFKDGTTSKRPFTSPDKTEELIKYILGRISAMRKEMCEKYDKCENSKEALSENNLNLPKMTEKDGCFQSGFNQETCLMRITIGLLEFQIYLDYLQNYYEGDKGNTEAVQISTKALIQLLRQKVKQPEEVSTPNPITGSSLLNKLQTENQWMKNTKMILILRSLEDFLQFSLRAVRIM
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF.  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis.  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ANMK_SALPB
Sequence: MKSGRFIGVMSGTSLDGVDVVLAAIDETMVAQQASLTWPIPVHLKKGILDICQGQPLTLSQLGQLDTQLGRLFAQAVNALLAQQRLQPRDIVAIGCHGQTVWHEPTGEAPHTLQIGDNNHIVAHTGITVVGDFRRRDIALGGQGAPLVPAFHHALLGHPTEKRMVLNIGGIANLSLLFPGQAVRGYDTGPGNMLMDAWIWRQCAQPYDKDAAWAKEGQVILPLLQKMLRDPYFAASAPKSTGREYFNYGWLERHLTAFPGADARDVQATLAELTAVSIAQQVLLNGGCERLMVCGGGSRNPLVMARLAALLPGIEVSTTDKAGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGATEASVLGAIYPANPITQS
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PYRF_BARBA
Sequence: GVVDDNSNRERLIVGLDVPNIKQAEKLVTQLGDEVSFYKIGYQLAFSGGMDFVQDLIQARKKVFFDMKLLDIDHTVARAVENIAKLGVSMLTLHAYPTVMKAAVAAAKGSDLCLLGVTVLTSMDEADLHNAGYKDSPKKLAFKRAEQAREAGMGGIVSSALEAAALRKVIGSDMALVTPGIRPMGSDKGDQKRVMAPRQALDSGASHLVVARPIIQADDPLVATKKILAEMADGC
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: FAN1_CAEEL
Sequence: MKKAKKEKKEKIIKPDGPINFNRSIMAAFEKQSRGKICPLCETKFSLASYKSHMNTCNVADDDEEIEVIATYTRDEAILMRAGPEIILGDASFSDKSENPTKRRKTDEREVPSEDDIVPEVPGPSGIVKNHEMPSESLDVTEISENIEKVIKKSPEWINHRRRSSRLLQNSQKDQADNANKEDPVKKETATISEVLQAIERFEQRVSGPEQTWPYYIKITIKIMKRVISTEKFDGTFYADDFWLPSDIITFYRFVELLSEGAKCLLVRLFIRKPAWYNLEKLEQKYPEIPNIKEAVSELAKGHFIDDDSSMKTLDEALQISDVVALKNVTKKFKLDGTKNRQELIQSLRKFAQSQQSIFGGTGNVEKSILKSLKQELGPCVRVRGGFVDLFKCLFTIYCPVTTNSANVIDNPSTTNVYQDLLYLMLSVANGTVQFPAPNPCPIIASFYKNRNMLQDYMISKSLEIAIVSQMSNGNLDAALDLAIDAKEFIEQMSDDDKRYYESLEIHERKFTSIWVFTRCCGHASSILERQKKYGMAVEWQKDLLITNKDIQSYCIDSRGIWWDRMLLNLDSHLKEKKECAKMIQIALQDPSILEKELLMIQDRALKLKEMPADFVTPINIGNPEKKTITANVITKSLGDGRINRFMIRDHETDDDVECSVEEVTRRHYLENEGFSTGVHDEGSTWHTLFGLFFYDVIFATDESVESTWLSELQDCPSDLSNTLYSKRKEKFEDRFVWLEEAEQELIEENIRKIWDLKHNETNRECSWKQFPMGAEDCVSFFQCIPRPALILILRRLAENYRNSRSGFPDLTLWNPETKRVAVVEVKGPGDRLSTKQRLWLAIFADSGIRAEVCHVAAQNSRLLV
What is the function of this protein?
Nuclease required for the repair of DNA interstrand cross-links (ICL).  Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
What are the official names of this protein?
Fanconi-associated nuclease 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the FAN1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENV10_YEAST
Sequence: MAGKAGRKQASSNAKIIQGLYKQVSLFLGMAIVRLFISRKVTIGQWIKLVALNVPMFVALYIIVLSGKPKYDGNRVVKQGIDLNDNTNLISYFFDLIYLSLFGNIGIIAFRTFKFWWCLLLCPIYAGYKLYGLKNMFMPGAQQTQADNRSKNANEGQSKSKRQMKRERRGETDSKIKYKYR
What is the function of this protein?
Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum.  SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431).  Involved in vacuolar processing and morphology (PubMed:21912603).
What are the official names of this protein?
SRP-independent targeting protein 2, Late endosome and vacuole interface protein 10.
What is the protein family that this protein belongs to?
Belongs to the TMEM208 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL13_SHEB8
Sequence: MKTFTATPETVTRDWFVVDADGKTLGRIATEIAIRLRGKHKPEYTPHVDTGDYIIVVNAEKVTVTGNKAKGKTYYSHSGFPGGIKQISFEKLQAQKPEMIIEKAVKGMLPKGPLGRAMFRKLKVYAGAEHNHTAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ACKA_MYCMM
Sequence: MSASRPNRVVLVLNSGSSSLKFQLVEPDSGMSRATGNIERIGEESSSVPDHDAALRRVFEILAEDDIDLQSCGLVAVGHRVVHGGKDFYEPTLLNDAVIGKLDELSPLAPLHNPPAVLCIRVARALLPDVPHIAVFDTAFFHQLPPAAATYAIDRELADVWKIRRYGFHGTSHEYVSQQAAEFLGKPIGDLNQIVLHLGNGASASAVAGGRPVETSMGLTPLEGLVMGTRSGDLDPGVIGYLWRTAKLGVDEIESMLNHRSGMLGLAGERDFRRLRAMIDDGDPAAELAYDVFIHRLRKYVGAYLAVLGHTDVVSFTAGIGEHDAAVRRDTLAGMAELGISLDERRNACPSGGARRISADDSPVTVLVIPTNEELAIARHCCSVLVAV
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.