PharMolix/UniProtQA huggingface dataset:
Protein: CXL17_MOUSE
Sequence: MKLLASPFLLLLPVMLMSMVFSSPNPGVARSHGDQHLAPRRWLLEGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRACQQFLKRCHLASFALPL
What is the function of this protein?
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:24973458).  Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774).  Acts as an anti-inflammatory in the stomach.  May play a role in the innate defense against infections.  Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.
What are the official names of this protein?
C-X-C motif chemokine 17, 6-Cys CXCL17, 13.6 kDa protein, VEGF coregulated chemokine 1.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_NITST
Sequence: MAVKTYQAGVTEYRQSYWQPDYAPLDTDLLACFKITPQPGVDREEAAVAVAAESSCGTWTTVWTDLLTDLDYYKGRAYRLEDVPGDDTCFYAFIAYPIDLFEEGSVVNVFTSLVGNVFGFKAVRALRLEDLRFPIAYVKTCGGPPNGIQVERDKLNKYGRLLLGCTIKPKLGLSAKNYGRACYEALRGGLDFTKDDENINSQPFMRWRDRFDFVMEAVQKAEQETGERKGHYLNVTAPTPEEMYKRAEHAKEIGAPIIMHDYLAGGLCANAGLANWCRNNGMLPHVHRAMHAVLDRNPHHGIHFRVLTKILRLSGGDHLHTGTVVGKLEGDRASTLGWIDLLRESFVPEDRSRGIFFDQDWGSMPGAFAVASGGIHVWHMPALVAIFGDDSVLQFGGGTLGHPWGNAAGAHANRVALEACVQARNEGRQIEKEGREILTAAAQHSPELKIAMETWKEIKFEFETMDKLAIANK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: FSQG_ASPFU
Sequence: MSNASDHVDVLIIGAGPAGLTTANSFNGSNCRVRLIDWKPAPLETGRADGLKSISLEVLDSFGIGDRVLNDCQPCEEIVLWNPGKDGVIARTMTIPDKVEELGQIERVMVENLYRHKTVQVNWNTQPVRLHIAPVTKDEPEAHPLTITVQNKETLGQETIRAKYVVGADGAHSWLRKYLNIGFSGDVTDSTWGVMNLVPKTDFPDIRKVFVVHSRAGTVMGVPREDKLVRLYISMDGGNRHTSIDAKSITAENLLQAARAILAPYRLDAARIPWWSAYCVGQRVADEFARHNRIFLAGDAVHTHSPKAGQGMNTSIQDGYNIGWKLRYCLEQKASPALLSTYQTERRPIAQALIDFDRKYLESFTRRDITHQEFLEAYLAGQRFTTGIQIQYPPSLIVTAKHLHAPSHPLATNLAPGKRLPDFQMVNQSDAVPIQAYHRFTSDGRFRLLVFPGDISQALAFGRFSRLGDWLTSHLPPSSGLEIITIHGARRADVELMDLHPAFRPWSDEEGWNYWTVYADDDSYHKGHGHVYERCGISKEDGVLVLLRPDGYISLIASFDETHELIDFFDGLQSGPRTVPQPERRANL
What is the function of this protein?
Phenol 2-monooxygenase; part of the gene cluster that mediates the biosynthesis of the isoquinoline alkaloids fumisoquin A, fumisoquin B and fumisoquin C; as well as small amounts of fumipyrrole as a shunt metabolite (PubMed:25582336, PubMed:27065235).  The products of the cluster lead to a brown coloration and are important for growth and conidiation (PubMed:25582336).  The nonribosomal peptide synthetase-like protein fsqF, which lacks a canonical condensation domain, is required for addition of a serine-derived dehydroalanine moiety to activated tyrosine but is not essential for the subsequent steps leading to isoquinoline formation (PubMed:27065235).  A different enzyme, most likely the ATP-grasp enzyme fsqD, is responsible for activation of tyrosine (Probable).  Three additional enzymes encoded by the fsq cluster, the N-methyltransferase fsqC, the phenol 2-monooxygenase fsqG and the FAD-dependent oxidase fsqB, catalyze the formation of the isoquinoline ring system in the fumisoquins (PubMed:27065235, PubMed:30194285).  FsqB converts the fspF thiolation domain-bound (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl into isoquinoline (PubMed:27065235, PubMed:30194285).  The cyclization most likely proceeds via a two-step mechanism, beginning with FAD-dependent oxidation of the methyl group to an iminium species followed by electrophilic attack on the deprotonated phenol (Probable).
What are the official names of this protein?
Phenol 2-monooxygenase fsqG, Fumipyrrole biosynthesis protein F, Fumisoquins biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: J_BPCHP
Sequence: MVRRRRLRRRISRRIFRRTVARVGRRRRSFRGGIRF
What is the function of this protein?
Mediates ssDNA packaging into virion, it locates to the internal surface of the capsid.  Additionally, plays a role in viral attachment to the host cell (By similarity).
What are the official names of this protein?
DNA binding protein ORF8.
What is the protein family that this protein belongs to?
Belongs to the microviridae J protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: SYDND_WOLSU
Sequence: MYVLRTHLCTQLGEGNIGEEVILCGWCNTYRDHGGVIFIDLRDKSGIIQLVSDPDDSPKAHENARVVRDEFVLIAKGKVRARGTGLENPKLATGKIEVILEELIIENRSLTPPITIGDESVGEDLRLKYRFLDLRNPKAYDTFRLRSKAAIAARNSLDGMGFLEVETPILTKATPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMISGFDRYFQIAKCFRDEDLRADRQPEFTQIDVEMSFCDQEDVMGVAEKLLGDIFSACGHTIPEHFPHLTYDRAMEEYGSDKPDLRFEMPLVEVIDLFGDSNNEIFAKIAQDSKKNRFKALKVKGGDLFFTRKTLGVLEEFVKKFGAAGLAYIQVKEEGLKGPLVKFMSERSLSLLLERLNPEVGDIIFFGAGEKKSVWDYMGRLRLEVAKQMGLIDPNQLCFLWVVNFPMFEKDEGKVKALHHPFTMPKNLDCEDVEEISSIAYDVVLNGVELGGGSIRIHQEAIQKRVFDLLGIAPEEAQEKFDFLLEALKFGAPPHGGFAIGFDRLIMLLTQSPSIRDVIAFPKTQKATCPLTSAPSPVSSEQLKELHIRIKEKTQTH
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBB1_LUPAL
Sequence: SLASKPCCDSCLCTRSIPPQCRCTDIGETCHSACKSCICTRSFPPQCRCSDITHFCYKPCTSS
What is the function of this protein?
Inhibits trypsin stoichiometrically at the molar ratio of 1:2, with a dissociation constant of 4. 2 nM.  Does not inhibit chymotrypsin.
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor, LaBBI.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: NADK_CHLAD
Sequence: MLERVAVLYNPLSDASIKLSRELTDWLIARGIKTRRGVSQEFRDQPQLVADCDLMIALGGDGTVLRAARLCFPHNIPVLPVALGHLSFMAEIGPEEVYSGCEQIMNGGGWFDERTLVRAQLWRNGQKLGQHTALNEVVISRSDISRIVNVHVTIDDSPLTTYHADGVIVATATGSTAYALAAGGPIVDPRSQALVLVPIAAHLTNIPSMVLHEDAVVTMQLRSRHHALLAVDGRENIDLIEGDEVVVRRSPQVCTFVRLRPSNQFYTQLVARLRRS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_HAHCH
Sequence: MAREFSRLDRVAEQIQKELAQLIQRELKDPRLGMVTVNSVKVSKDLSYADVYVTVLNLKDVEDDGDASKASLKVLESAAGFLRSELGRAIKLRVMPQLRFHYDASVSNAQRLGALIQKARAKDSSASDSSDDSHN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HVM48_MOUSE
Sequence: MGWSYIILFLVATATDVHSQVQLQQPGAELVKPGASVQLSCKASGHTFTNYWIHWVKQRPGQGLEWIGEINPNDGRSNYNEKFKNKATLTVDKSSSTAYMQLSSLTPEEFAVYYCARSDGYYDWFVYWGQGTLVTFSA
What are the official names of this protein?
Ig heavy chain V region TEPC 1017.
Protein: ORF2_TTVZ1
Sequence: MGDWFMQGSPPDFAVQEDRWLKAVESCHQLFCSCSSAWDHLRNILQTRGYWPQGPPPYRSEPHTEHSRPPPPKKRRPWCGGDGGGDAGAGPSGVAGTAAGGAGGDGAVGPVEEDDPTVADLIAAMEEDER
What are the official names of this protein?
Uncharacterized ORF2 protein.
Protein: CEMA_ACOCL
Sequence: MPKKKGFTPLPYLASIVFLPWWVSLSFNKSLEPWVTNWWNTRQSETFLNDIQERNVLERFIELEELFLLDEMLKENPETRMKNLRIGIHNETIQLVKTDNEYHLHTILHFSTNIICFAILSVYSILGNEELVILNSWVQEFLYNLSDTIKAFSILLVTDLWIGFHSPHGWELMIGSVYNDFGLAHNEQIISGLVSTFPVILDTIVKYWIFHYLNRVSPSLVVIYHSMND
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: XERC1_RALSO
Sequence: MPPSAPDDDRDAPAPPHPQIGAYLDALKFERKLSQHTLASYARELAVLQQLGARFAAGIDLMRLQPHHIRRMMAQLHGGGLSGRSIARALSAWRGWYQWLALRDAAVTANPVDGIRAPKSPKRLPKALSVEQAVALMEQLPGDDPEAVRDRAVNELFYSCGLRLSELVGLDLRHAQAGDYASASWLDLEAREVTVLGKGNKRRTVPVGSKAAEALAAWLAVRPQLAQPDAAPEDAHALFLSARGKRLAQRQIQTRMKRNAIAAGVPADVHPHVLRHSFATHMLQSSGDLRAVQELLGHASIASTQVYTSLDFQHLAKIYDQAHPRAKKK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids (By similarity).
What are the official names of this protein?
Tyrosine recombinase XerC 1.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP4_ROTCU
Sequence: MASLIYRQLLTNSYTVNLSDEIQEIGSTKTQNITINPGPFAQTGYAPVNWGPGETNDSTTIEPVLDGPYQPTSFNPPVGYWMLLSPTAPGVVVEGTNNTDRWLATILIEPNVTSQQRTYTIFGVQEQITVENTSQTQWRFVDVSKTTQNGSYSQYSPLLSTPKLYAVMKYGGRIHTYSGQTPNATTGYYSATNYDSVNMTTFCDFYIIPRSEESKCTEYINNGLPPIQNTRNIIPLALSARNVRSLKAQSNEDIVVSKTSLWKEMQYNRDITIRFKFANSIVKSGGLGYKWSEISFKPANYQYTYMRDGEEVTAHTTCSVNGMNDFSFNGGSLPTDLLISRYEVIKENSYVYIDYWDDSQAFRNMVYVRSLAANLNSVICAGGHYNFALPVGQWPYMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLAVEEPSFAIMRTRVSGLYGLPAANPNNGREYYEIAGRFSLISLIPSNDNYQTPIANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSIATNVMKKFKKSSLASSVSTLTDSLSDAASSLSRGSSIRSVGSSVSAWTDVSTQITDVSSSVSSISTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDKSIQISPNTLPDIVTEASEKFIPNRAYRVINNDEVFEASTDGRFFAYRVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGIGKQQAFNLLRSDPKVLREFINQNNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: HIS4_MYCA9
Sequence: MSLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRGSNRELLAQVVGELDVKVELSGGIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARHGERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRAQGCSRYVVTDVTKDGTLTGPNLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIAAVS
What is the function of this protein?
Involved in both the histidine and tryptophan biosynthetic pathways.
What are the official names of this protein?
Phosphoribosyl isomerase A, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, N-(5'-phosphoribosyl)anthranilate isomerase, PRAI, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_BURO1
Sequence: MTDTLFDRADIDALLAGRHPDPFACLGPHRHDDQIVVRALLPGAERVRALSPDGAELGTLACVDRAGCFAGTIAHDGGAPHYLLSIDWPDAHQVTDDAYAFGTLLDEAALARFSAGDPEAVLDCLGATPVRIDDTDGVRFAVWAPSAQRVSVVGDFNAWDGRRHPMRLRRPSGVWELFVPGIGAGERYKYELCAADGRVLPHKADPCARATEAPPRTASVVADVAALHAFAWHDDGWMHARPRHDDRYRVPWSIYEVHPESWQRIPEQMDRSATWDELAERLIPYVKGMGFTHVEFMPIAEYPFGGSWGYQPLAQFAPSARFGPVEGFARFVDRAHAAGIGVLVDWVPAHFPNDAHGLAQFDGSALYEHADPREGMHPDWNTCVFNVGRTEVSAFLVASALAWARRYHVDGIRVDAVASMLYRDYSRKEGEWVPNVYGGRENLESVAFLRRLNDTLHGDAAPAGVVTVAEESTAWPGVTAPTADGGLGFDFKWNMGWMHDTLAYLHEDPIHRRYHHDRMTFGLVYAFSERFVLPLSHDEVVHGKGSLVAKMPGDAWQRLATLRAYFGFMWAHPGKKLLFMGSEFAQWSEFAHDATPHWDLLDAPAHRGVQRLVRDLNRAYAAEPALHALDCHAAGFAWLIGDDRDNSVFAFARRDDTGRLVVAVCNFTPVPRAGYRLGLPAPGHWRELMNTDAASYGGANAGNDGAVWAEAVPAHGEAWSASLRLPPLATLWLTPA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: UBIG_ECO57
Sequence: MNAEKSPVNHNVDHEEIAKFEAVASRWWDLEGEFKPLHRINPLRLSYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQNK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone-8 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: DACA_ECOLI
Sequence: MNTIFSARIMKRLALTTALCTAFISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADFAAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNSSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFHHWFG
What is the function of this protein?
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
What are the official names of this protein?
D-alanyl-D-alanine carboxypeptidase DacA, DD-carboxypeptidase, DD-peptidase, Beta-lactamase, Penicillin-binding protein 5, PBP-5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S11 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=N-terminal lies in the periplasmic space.
Protein: OTAD_ASPNC
Sequence: MEIPHKATVLVIGGGPGGSYTASALAREGIDIVLLEADVFPRFIDLDETFVNYGFVRKNASHGSLADTDFILQPGADTFAWNVVRSECDDLMFKHASNSGARAFDGVKVTAIEFDPLDESAIDDHPGRPVSASWKAKDGRTGSISFDYLVDASGRAGIASTKYLKSRTYNSYLKNVASWGYWRGATPYGVGTSVEGQPYFEALQDGSGWVWFIPLHNGTTSVGVVMNQELATQKKKSSTVTSSRAFYLESVEGARVISQLLQPANLDGEIKQASDWSYNASSYGSPYLRIVGDAGAFIDPYFSSGVHLAVSGGLSAAVSIAASIRGDCPEHTAWQWHSQGVANRYGRFLLVVLGATKQIRARDSPVLNSEGQDGFDDAFAVIRPVIQGTADVQGKVSAREVLDAVTFSTNAVRPSAGGQNVVLEESSRSLRSQVEQEMGDVANSLAKAYKDTDVYEGLMARLERGSLGLKAVGVMG
What is the function of this protein?
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of ochratoxin A (OTA), a mycotoxin composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenylalanine, and demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties (PubMed:27667988, PubMed:33391201).  OtaD chlorinates ochratoxin B (OTB) at the C-5 position to form OTA (By similarity).  The pathway begins with the highly reducing polyketide synthase otaA that catalyzes the formation of the isocoumarin group during the initial stages of biosynthesis, starting from one acetate and 4 malonate units, to originate the characteristic pentaketide skeleton 7-methylmellein (7-MM) of the OTA molecule.  The newly identified cyclase otaY might be involved in the polyketide cyclization reaction during the initial steps of the OTA biosynthesis.  7-MM is then oxidized into 7-carboxymellein (also called ochratoxin beta) by the cytochrome P450 monooxygenase otaC.  The NRPS encoded by the otaB gene is involved in the linking of phenylalanine to the dihydroisocoumarin ring.  The reaction catalyzed by NRPS results in the production of ochratoxin B (OTB), which is the non-chlorinated analog of OTA and which subsequently serves as the substrate of the halogenase otaD for chlorination activity to form the final molecular structure of OTA, containing a chlorine atom in the C-5 position of the molecule (PubMed:27667988, PubMed:33391201) (Probable).
What are the official names of this protein?
Flavin-dependent halogenase otaD, Ochratoxin biosynthesis cluster protein 5, Ochratoxin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: G3PB_ARATH
Sequence: MATHAALAVSRIPVTQRLQSKSAIHSFPAQCSSKRLEVAEFSGLRMSSIGGEASFFDAVAAQIIPKAVTTSTPVRGETVAKLKVAINGFGRIGRNFLRCWHGRKDSPLEVVVLNDSGGVKNASHLLKYDSMLGTFKAEVKIVDNETISVDGKLIKVVSNRDPLKLPWAELGIDIVIEGTGVFVDGPGAGKHIQAGASKVIITAPAKGADIPTYVMGVNEQDYGHDVANIISNASCTTNCLAPFAKVLDEEFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVSLVLPQLKGKLNGIALRVPTPNVSVVDLVINVEKKGLTAEDVNEAFRKAANGPMKGILDVCDAPLVSVDFRCSDVSTTIDSSLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAHLVASKWPGAEAVGSGDPLEDFCKTNPADEECKVYD
What is the function of this protein?
Involved in the photosynthetic reductive pentose phosphate pathway (Calvin-Benson cycle).  Catalyzes the reduction of 1,3-diphosphoglycerate by NADPH (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic, NADP-dependent glyceraldehydephosphate dehydrogenase B.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast stroma.
Protein: RPOA_VIBA3
Sequence: MQGSVTEFLKPRLVDIEQINTTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIEGVLHEYSTKEGVQEDILEILLNLKGLAVRVAEGKDEVFITLNKSGSGPVVAGDITHDGDVEIANPEHVICHLTDDNAEIAMRIKVERGRGYVPASARIHTEEDERPIGRLLVDATYSPVDKIAYAVEAARVEQRTDLDKLVIDMETNGTLEPEEAIRRAATILAEQLDAFVDLRDVRVPEEKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIAED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: KV3AJ_MOUSE
Sequence: DIVLTQSPASLAVSLGQRATISCRASKSVSTSGYSYMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPLTFGAGTKLELK
What are the official names of this protein?
Ig kappa chain V-III region PC 7175.
Protein: COAA_PECAS
Sequence: MSNRDQSLATPYLQFNRSQWAALRDSVPLTLTEEEIVKLKGINEDLSLDEVAEIYLPLSRLLNFYINSNLRRQAVLEQFLGTDGQKIPYIIGIAGSVAVGKSTTARVLQALLSRWPEHRSVELITTDGFLHPNKVLKERDLMKKKGFPQSYDMHSLVKFVSDIKSGTHQVTAPTYSHLTYDIVPNNNKVLEQPDILILEGLNVLQSGMDYPHDPHRVFVSDFVDFSIYVDAPETLLQPWYINRFLKFRQGAFSNPNSYFHNYAKLTEEEAVGIASQLWKEINGLNLKENILPTRERASLIMTKSANHAVECVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_PROHU
Sequence: MIPGEIRVNQALGDIELNAGRETKIIQVANHGDRPVQVGSHYHVYEVNEALKFEREETLGFRLNIPAGMAVRFEPGQCRTVELVAFDGKREIYGFHGKVMGKLESENK
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0572_MYCTU
Sequence: MGEHAIKRHMRQRKPTKHPLAQKRGARILVFTDDPRRSVLIVPGCHLDSMRREKNAYYFQDGNALVGMVVSGGTVEYDADDRTYVVQLTDGRHTTESSFEHSSPSRSPQSDDL
What are the official names of this protein?
Uncharacterized protein Rv0572c.
Protein: RECA_BORPE
Sequence: MDDKTSKAAAAEKAKALAAALSQIEKQFGKGSIMRYGDNEVEHDIQVVSTGSLGLDIALGVGGLPRGRVIEVYGPESSGKTTLTLQVIAEMQKLGGTCAFVDAEHALDVQYASKLGVNLTDLLISQPDTGEQALEITDALVRSGSVDLIVIDSVAALVPKAEIEGEMGDSLPGLQARLMSQALRKLTATIKRTNCMVIFINQIRMKIGVMFGNPETTTGGNALKFYSSVRLDIRRIGAIKKGDEVVGNETRVKVVKNKVAPPFKQAEFDIMYGSGISREGEIIDLGVQANVVDKSGAWYSYSGNRIGQGKDNVREYLKEHKEMAIEIENKVRENQGIVSRAATFPASEAEDGE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.