PharMolix/UniProtQA huggingface dataset:
Protein: EIF3E_MOUSE
Sequence: MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.  Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway.  May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e, Eukaryotic translation initiation factor 3 subunit 6, MMTV integration site 6, Mammary tumor-associated protein INT-6, Viral integration site protein INT-6, eIF-3 p48.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, PML body.
Protein: SWI5_RAT
Sequence: MIDEGEEVTEETLNSDIQKLKEKQDMLDKEISQLIAEGYRVIELEQHISLLHEYNDIKDVSQMLLGKLAVTRGVTTKELYPDFDLNPND
What is the function of this protein?
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
What are the official names of this protein?
DNA repair protein SWI5 homolog, Protein SAE3 homolog.
What is the protein family that this protein belongs to?
Belongs to the SWI5/SAE3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: APF11_GIBF5
Sequence: MGDISAATKAPAPPTPATPETNTTSSSSDTDVQHEPQIPSAASRNLVIFALGLAILVGVLDATIVATLVPTIADDFHSVDSSAWYGSAYLLVTGATQPIFGKIYSTFQSKLVFLSSVAILEVGSLVCALAKNSPTFIGGRAIAGLGAAGVISGGLIITALTTPLKQRPVYTAILGSLEGVGVIIGPIIGGQIASSIGWRWCFWINLPIGAVLCAILVFCLHPPKQTPEREQEQAGKTWTQKLAQLDLEGGLAIAGSITCLLLALEWGGTSYPWSDGRIIVLLVVFGVSLICVAVHQHWKGEAATFPTRLLKNRTFSMFLLCGLCFAGAQFTVLYYLPMWFQAVQGVSAAESGTRLLAMVVSVIVVSVIAGGSAGAVGYLPPFVFFATIFSSIGAGMLYTLHPSISKSKWIGYQILFGAGSGTGIQQAIVGVQVAVDHDDMAYATSAVMLVNTLAGSIFIAVSQTLFLGEMKRVTELIPNLDRHTLLSNFRSIRDKLDHQELDIAVNAYNRGITKAFLIGLVLCSITVLTWPLIRWIPLKKTEDPVKSERRNDPETLNAGNVA
What is the function of this protein?
Efflux pump; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475).
What are the official names of this protein?
Efflux pump apf11, Apicidin F synthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CETP_RABIT
Sequence: ACPKGASYEAGIVCRITKPALLVLNQETAKVVQTAFQRAGYPDVSGERAVMLLGRVKYGLHNLQISHLSIASSQVELVDAKTIDVAIQNVSVVFKGTLNYSYTSAWGLGINQSVDFEIDSAIDLQINTELTCDAGSVRTNAPDCYLAFHKLLLHLQGEREPGWLKQLFTNFISFTLKLILKRQVCNEINTISNIMADFVQTRAASILSDGDIGVDISVTGAPVITATYLESHHKGHFTHKNVSEAFPLRAFPPGLLGDSRMLYFWFSDQVLNSLARAAFQEGRLVLSLTGDEFKKVLETQGFDTNQEIFQELSRGLPTGQAQVAVHCLKVPKISCQNRGVVVSSSVAVTFRFPRPDGREAVAYRFEEDIITTVQASYSQKKLFLHLLDFQCVPASGRAGSSANLSVALRTEAKAVSNLTESRSESLQSSLRSLIATVGIPEVMSRLEVAFTALMNSKGLDLFEIINPEIITLDGCLLLQMDFGFPKHLLVDFLQSLS
What is the function of this protein?
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles.  Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641).  Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity).
What are the official names of this protein?
Cholesteryl ester transfer protein, Lipid transfer protein I.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in plasma.
Protein: FLIE_AGRFC
Sequence: MIDGIKQLGSLSLTRGASGVSSLTESLFGGEQQSTPAQQTGASFASVLGNVSMDAMNNLKKAEVASFEGIQGKANTREVVDAVLSAEQSLQTAIALRDKIVSAYLDITKMQI
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: ITPK4_ORYSI
Sequence: MAPELSSPSSSPRYTVGYALLPEKVSSVVRPSLVALAADRGVRLVAVDVSRPLAEQGPFDLLVHKMYDRGWRAQLEELAARHPGVPVVVDSPGAIDRLLDRATMLDVVSGLRTPVSVPPQVVVSDAAADADELLARAALRFPLIAKPLAVDGSAESHDMRLVYRRDGVLPLLRAPLVLQEFVNHGGVLFKVYVVGDRATCVRRSSLPDVPARRLLDLDAEPSVPFANISNQPLPPPDDDGGAADDDTPAAGFVDEVARGLRRGLGLHLFNFDMIRERSEEHGDRYFIIDINYFPGYAKMPGYEAALTDFFLEMLRGTRPVPEQLGPGSGLDMEARKLEPGLGIGLRELESGRAQA
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds.  Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase 4, Inositol 1,3,4-trisphosphate 5/6-kinase 4, Inositol-triphosphate 5/6-kinase 4, Ins(1,3,4)P(3) 5/6-kinase 4, OsITP5/6K-4, OsITPK4.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: FRDD_HAEIE
Sequence: MVDQNPKRSGEPPVWLMFGAGGTVSAIFFPVVILIIGLLLPFGLVDAHNLITFAYSWIGKLVILVLTIFPMWCGLHRIHHGMHDLKVHVPAGGFIFYGLATIYTVWVLFAVINL
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FIXA_ECO8A
Sequence: MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEAQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAVDAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: Y1552_HAEIN
Sequence: MKTKFYDYQGEHLILYFAGWGTPPDAVNHLILPENHDLLICYDYQDLNLDFDLSAYRHIRLVAWSMGVWVAERVLQGIRLKSATAVNGTGLPCDDSFGIPYAIFKGTLENLTENTRLKFERRICGDKASFERYQLFPARPFDEIHQELTALFAMIQQDKRIDLIHWANAWVSSRDKIFTPANQHQYWALRCAVQEIEGEHYVFSRFTHWSALWDH
What are the official names of this protein?
Uncharacterized protein HI_1552.
Protein: NMT2_BOVIN
Sequence: MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ
What is the function of this protein?
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.  Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'.  Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.
What are the official names of this protein?
Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Peptide N-myristoyltransferase 2, Type II N-myristoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NMT family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: SPT5_EMENI
Sequence: MSRNLMDQDFGSEEEDDDFNPAPAEESDNEEAHHDKTRKPDRDSDARNGSDDEGADEAGEEDEEENEEGGEGEGDEEEDEEEDEDDDDVSKPRKRRKGHGGLSAFIDYEAGVDEEEDEVEDEEEEEGYGLEQHPDDVLPAGAETDDRQHRRLDRERELAATLDAEKQAQLLKERYGRNRAAATDAVIVPKRLLLPSVDDPSIWGVRCKAGKEREVVFSIQKRIEDRPPGSRNPIKIISAFERGGAMSGYIYVEARRQADVMDALQDMSNVYPRTKMILVPVKEMPDLLRVQKSEELNPGGWVRIKRGKYMNDLAQIEEVETNGLAVTVRLVPRLDYGMNEDSGAPIMDPKRKRPGANPAVARPPQRLFSEAEAKKKHSKYLTATAGLGAKSWNYLGETYIDGFLIKDMKVQHLITKNVNPRLEEVTMFARDSENGTSNLDLASLAETLKNSTAEESYLPGDPVEVFKGEQQGLVGRTSSTRGDIVTILVTEGELAGQTIEAPVKTLRKRFREGDHVKVIGGSRYQDELGMVVQVRDDTVTLLSDMSMQEITVFSKDLRLSAETGVDGKLGMFDVHDLVQLDAATVACIVKVDRESLRVLDQNGSIRTILPSQVTNKITPRRDAVATDRNGAEIRHGDTVREVYGEQRSGVILHIHRSFLFIHNKAQAENAGIVVVRTTNVVTVSAKGGRPTGPDLSKMNPALMRNGAPGGMMAPPPSKTFGRDRLLGKTVLVKKGPFKGLLGIVKDTTDVQARVELHSKNKLVTIPKELLVVKDPVTGQTIDIGRGRGGPRVPQNSAAPSSGWQGGRTPMAAADSSRTPAWGAAMSSRTPAWSGAGLGSRTPAWKADGSRTAYGGAGSRTPAWNAGARTPYGGGFGSGSGNSDFDAFAAGSRTPAWGAASGSRTPAWSASANTTSRNDNKAYDAPTPGATYSAPTPGAYGGAPTPGLSAPTPGAWADSAPTPGAYNAPTPADFGEGSRPYDAPTPAMGGAAATPGAGAYGDTDDGAPRYEEGTPSP
What is the function of this protein?
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor spt5, Chromatin elongation factor spt5.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOT2_RAT
Sequence: MPSESSVKATAAPPPFPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINRFLDFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIYLLICNAINYRLLEKERKREKARRKKSASQASKEMEALSRSKQDDVTVKVSNTHNPPSDRDKESSI
What is the function of this protein?
Proton-coupled monocarboxylate symporter.  Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:10417314, PubMed:20695846).  Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPP24_CHICK
Sequence: MGKTPEDFERHTMRSLIFVLALSVFTCSGFPVYDYELPVTEEALNASIARINSQTWGPNLYGVVRSHVRHVDMWNSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCHQSTFSSESMSSEEMTYMLMTDPRKRGSSRSEAFSSRGRGHSNGDWRKPDYTSPGKVE
What is the function of this protein?
Could coordinate an aspect of bone turnover.
What are the official names of this protein?
Secreted phosphoprotein 24, Spp-24, Secreted phosphoprotein 2.
What is the protein family that this protein belongs to?
Belongs to the SPP2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNT_SHEON
Sequence: MSDICDANKLKHRFRGYFPVVIDVETAGFNSQTDALLEIAVTLLKMDDEGLLGIDKTLHFHIEPFEGANLEPEALAFNGIDPTNPLRGAVSEKDAFLEIFKAVKKAQKASDCHRSIIVAHNAAFDHGFVSKAIERCDLKRSPFHPFATFDTATLAGLAIGHTVLAKACIMAGIPFDNKEAHSALYDTERTAELFCYIVNRWKTLGGWPLLATSESEDMDSEE
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: CLD14_MOUSE
Sequence: MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPRDLQAARALMVISCLLSGMACACAVVGMKCTRCAKGTPAKTTFAVLGGALFLLAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYPPQSRAGATTTATAPAYRPPAAYKDNRAPSVTSAAHSGYRLNDYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-14.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: RR16_SORBI
Sequence: MVKLRLKRCGRKQQAIYRIVAIDVRSRREGRDLRKVGFYDPIKNQTCLNVPAILYFLEKGAQPTRTVYDILRKAEFFKDKERTLS
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TBL31_ARATH
Sequence: MSIQTTADSRMIQSIFQVVLVSLLVLGSVRWILDELKSKESRISKLYGFRQKEAVFVTKEDQLDESCNVFEGQWVWDNVSYPLYTEKSCPYLVKQTTCQRNGRPDSYYQNWRWKPSSCDLPRFNALKLLDVLRNKRLMFIGDSVQRSTFESMVCMVQSVIPEKKKSFHRIPPMKIFKAEEYNASIEYYWAPFIVESISDHATNHTVHKRLVKLDAIEKHSKSWEGVDVLVFESYVWWMHQPKINATYGDTSEVREYNVTTAYKMALETWAKWFKTKINSEKQKVFFTSMSPTHLWSWEWNPGSDGTCYDELYPIDKRSYWGTGSNQEIMKIVGDVLSRVGENVTFLNITQLSEYRKDGHTTVYGERRGKLLTKEQRADPKNYGDCIHWCLPGVPDTWNEILYAYLLRSHRNFF
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 31.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: GUAA_BRASO
Sequence: MTAPANNTPAAAATDTSVAALHDKILIVDFGSQVTQLIARRVREDGVYCEIVPFQKAEAAFRQMNPKAVILSGGPESVHEEGSPRAPQLIFESGVPVMGICYGQMTMAAQLGGTVEGGHHREFGRADVEVKTNSLLFDGVWQPGEQHQVWMSHGDRITQMPPGFSVAGVSPNAPFAVIQDEARKYYGLMFHPEVVHTPDGAKLIRNFVRNISGLGGDWTMHAFREEEIKKIRAQVGQGKVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLLRLNEAETVVDLFRHHYNIPLVHVDASKLFLGELAGVTDPEAKRKTIGRLFIDVFEAEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPARMNMKLVEPLRELFKDEVRVLGRELGLPDVFVGRHPFPGPGLAIRCPGEITTDKLDILRKADAIYIDEIRKAGLYDTIWQAFAVLLPVKTVGVMGDGRTYDYVVGLRAVTSTDGMTADFYPFDMKFLGNTATRIINEVKGVNRVVYDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PAND_BACAA
Sequence: MFRTMMRAKLHRATVTEANLNYVGSITIDEDLMDAVNIVENEKVQIVNNNNGARLETYVIKGERGSGVVCLNGAAARLVQPGDKVIIICYGLVAEENIHKQEPKIAVLDDDNQIIEMLGAEKAGTIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_BRUA4
Sequence: MSVTLALPSKGRLKEQTLAVLDKAGYKVILPDDSRNYRARVEGETDLDILFLSASEIARELGYGSVDLGVTGEDLVRETLAHSEERVAIEAELGFGHADVVVAVPEVWRDVTSMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGVILRSQACLVSARRARENARVTEVATRIRKGLGG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_STAHJ
Sequence: MLKPLGNRVIIERKEQEQTTKSGIVLTDSAKEKSNEGIVVAVGTGRVLDNGEKVAPEVKEGDRVVFQEYAGSEVKRGDKTYLILNVEDLLAIIED
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1264_HALSA
Sequence: MDCRVVVEAAVPVYDVQSTDEAVRIAISKTGEMLNPDLNYVEIEMGSRSCPHCGTDTEPAFVAADESLVALELSMTVFNVERDEHAARIARKEIGQRLANIPLAVLEVDTVTDDDTQESTGGDTETA
What are the official names of this protein?
UPF0212 protein VNG_1264C.
What is the protein family that this protein belongs to?
Belongs to the UPF0212 family.
Protein: PUR5_ANASK
Sequence: MSLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSGTDGVGTKLKVAFAADRHDTVGIDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVVKGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGCVDRPRIVDGTRVARGDVVIGIASSGLHSNGFSLARKALLDRYPLDHRFEALGGRTLADALLEPTRIYAKDVLALLEQVPVRAFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPVIFDLVEREGQVPRDEMYRTFNMGLGLVAVVAPGDEAAAHAALRARGLEAWTVGAIEAGGPGEATCEVVR
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAF3_HUMAN
Sequence: MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
What is the function of this protein?
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556).  In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081).  Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines.  Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768).  Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development.  Required for normal antibody isotype switching from IgM to IgG.  Plays a role T-cell dependent immune responses.  Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B.  Promotes ubiquitination and proteasomal degradation of MAP3K14.
What are the official names of this protein?
TNF receptor-associated factor 3, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1, RING-type E3 ubiquitin transferase TRAF3.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Co-localized to mitochondria with TRIM35 (PubMed:32562145).
Protein: PCKA_ECO45
Sequence: MRVNNGLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTKQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIENIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.