PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_STRPJ
Sequence: MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELESLISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLVTGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQTSAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PPP6_MOUSE
Sequence: MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
What is the function of this protein?
Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:32474700).  PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (By similarity).  N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D13 During mitosis, regulates spindle positioning (By similarity).  Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity).  Acts as a regulator of innate immunity by mediating dephosphorylation CGAS, STING1 and RIGI (PubMed:32474700).  Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (By similarity).  Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700).  CGAS dephosphorylation at 'Ser-420' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700).
What are the official names of this protein?
Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: Y1689_LYSSC
Sequence: MLSKEKINRINELSAKAKNGQLTDEEAKERTALRKEYLDTFRATMRDTIENVKVVDAEGNDVTPEKVRQAKKNKFLN
What are the official names of this protein?
UPF0291 protein Bsph_1689.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_CHLT3
Sequence: MKLHIFKSKIHRATVTNADLYYEGSITIDMDLVDLAGMMPNEKVQVVNNNNGARFETYIIRGKRGSGTIQLNGAAARLASIGDEIIIITYAEMEPEEAKDYKPTVVLVDKKNRPKKIFQLGEETTPEEAPSLEQRN
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHA_PSECP
Sequence: MALIRRVALLSLHTSPMEQPGSGDAGGMNVYIRELASALAEAGVEVEIFTRATSASQPAVEHPDPGVCVHNVLAGPTKKIPKEELPGLLHSMVEEIEQIRRRQPHGRYDVIHSHYWVSGIAGLELSELWGVPLVHTMHTMAKVKNLLLESGEQPEPRRREVGEHRIVDGAARLIANTSSEAAELVSHYGADYDRIDIAPPGVDLATFTPAFRTKARRDHGVDPGTFHLLFAGRIQRLKGPQVLVKAAALLRQRRPDIDLRLTILGELSGNKEFNLRKLVADAEMDDVVTQLPPVTAPELAAWFRAADVVVMPSFSESFGLVALEAQACGTPVVATRVGGLSRAIFHGRTGLLVDGHHAADWADAFEALYDDPATRVDMGRAAAIRAQNSGWSRTAAITLESYHAAVDRHVGHLVPAVPVT
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: NTPPA_LEPBJ
Sequence: MIVLRSRSPRRKYVLESLDLDFRIEPEDIDESSLKNEHPLEYLKRICLSKLGTRSKDEFLISCDTIVVQENSILQKPKNFLEAVEMLERLSGKTHKVASGLGIYYKGLERFAFEFSQVHFRSWNHKQIREYVEKYSPFDKAGSYGVQDKEGPVRSFDGSYTNILGFPIRTFFQYHEFWKKYLKGN
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE2A_ORYSJ
Sequence: MERGEGRRGDCSVQVRKKRTRRKSDGPDSIAETIKWWKEQNQKLQEENSSRKAPAKGSKKGCMAGKGGPENSNCAYRGVRQRTWGKWVAEIREPNRGRRLWLGSFPTALEAAHAYDEAARAMYGPTARVNFADNSTDANSGCTSAPSLMMSNGPATIPSDEKDELESPPFIVANGPAVLYQPDKKDVLERVVPEVQDVKTEGSNGLKRVCQERKNMEVCESEGIVLHKEVNISYDYFNVHEVVEMIIVELSADQKTEVHEEYQEGDDGFSLFSY
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3' of the cis-acting dehydration-responsive element (DRE).  Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription.
What are the official names of this protein?
Dehydration-responsive element-binding protein 2A, OsDREB2A.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCA_HALSA
Sequence: MTDAAAVIERVRQRVDPTPAERRALAAAASRLTERAEAAIAELPVAADVVQVGSTARGTWVAGDRDIDLFVRFPSDLPREQLETYGTTVGAAVLPDGHEEYAEHPYVTGTFEGYAVDLVPCYDVAAATEIKSAVDRTPFHTTYLQEHLDDGLAADVRLCKQFLKGIGVYGSDLRTQGFSGYLCELLVVEYGGFEAMLAAIEDWQPPVVIDPAAHQQASFDDPLVVVDPTDPERNVAAVVSAANVATVQHHARRFRATPSEDAFTPASPAPLDAAALRSHIDRRDTTPLAVVLDAPDVVADQLYPQLYRSRDGVVRGLREHGFDVVRAAAWADERAVVFVELASAELPAVERHVGPPVSVGTHAERFYETYADDDGVYGPFVDDDGRYVVERDRDVRTAGGFARTELGTVALGARIESRVASGDYDVYVGDAVVEALLPEFESELAAYVDPKA
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: SECA2_STAAE
Sequence: MKHKLDVTINELRLKSIRKIVKRINTWSDEVKSYSDDALKQKTIEFKERLASGVDTLDTLLPEAYAVAREASWRVLGMYPKEVQLIGAIVLHEGNIAEMQTGEGKTLTATMPLYLNALSGKGTYLITTNDYLAKRDFEEMQPLYEWLGLTASLGFVDIVDYEYQKGEKRNIYEHDIIYTTNGRLGFDYLIDNLADSAEGKFLPQLNYGIIDEVDSIILDAAQTPLVISGAPRLQSNLFHIVKEFVDTLIEDVHFKMKKTKKEIWLLNQGIEAAQSYFNVEDLYSEQAMVLVRNINLALRAQYLFESNVDYFVYNGDIVLIDRITGRMLPGTKLQAGLHQAIEAKEGMEVSTDKSVMATITFQNLFKLFESFSGMTATGKLGESEFFDLYSKIVVQVPTDKAIQRIDEPDKVFRSVDEKNIAMIHDIVELHETGRPVLLITRTAEAAEYFSKVLFQMDIPNNLLIAQNVAKEAQMIAEAGQIGSMTVATSMAGRGTDIKLGEGVEALGGLAVIIHEHMENSRVDRQLRGRSGRQGDPGSSCIYISLDDYLVKRWSDSNLAENNQLYSLDAQRLSQSNLFNRKVKQIVVKAQRISEEQGVKAREMANEFEKSISIQRDLVYEERNRVLEIDDAENQDFKALAKDVFEMFVNEEKVLTKSRVVEYIYQNLSFQFNKDVACVNFKDKQAVVTFLLEQFEKQLALNRKNMQSAYYYNIFVQKVFLKAIDSCWLEQVDYLQQLKASVNQRQNGQRNAIFEYHRVALDSFEVMTRNIKKRMVKNICQSMITFDKEGMPVIHFP
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: RISB_MOOTA
Sequence: MPNIMEGQLEGRGLKFGIVVSRFNEFITSRLLDGALDALNRHGADPGAIDIAWVPGAFEIPLTAQKMAARGYDAVICLGAVIRGATPHFEYVAAEVTKGIAQVSLNSGVPVIYGLITADNIEQAIERAGTKAGNKGFDAAMTAMEMANLFKVMAR
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: NU3M_PERMA
Sequence: MNMLTALLVNITLSMLLIIVAFWLPQLNLYTEKANPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQMYNIDIMMLTAFILVSVLALGLAYEWLQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DEOC_YERPP
Sequence: MTTNYAHYIDHTLLAMDATEAQIIKLCEEAKQHHFYAVCVNSGYVPVAAQQLAGSSVKVCSVIGFPLGAGLTAAKAFEAQAAINAGAQEIDMVINVGWLKSGKIADVKADIKAVRDNCAATPLKVILETCLLSDEQIVQVCEMCRELDVAFVKTSTGFSTGGAKEEHVKLMRATVGPVMGVKASGAVRDRATAETMIQAGATRIGTSSGVAIVSGQQAAASGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR3_MACRS
Sequence: NYDKNFLRF
What are the official names of this protein?
FMRFamide-like neuropeptide FLP3, NYDKNFLRF-amide.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: OMPA_KLEAE
Sequence: MKKTAIAIAVALAGFATVAQAAPKDNTWYAGGKLGWSQFHDTGWYNSNLNNNGPTHESQLGAGAFGGYQVNPYLGFEMGYDWLGRMPYKGVKVNGAFSSQAVQLTAKLGYPITDDLDIYTRLGGMVWRADSSNSIAGDNHDTGVSPVFAGGVEWAMTRDIATRLEYQWVNNIGDAGTVGVRPDNGMLSVGVSYRFGQEDNAPVVAPAPAPAPEVTTKTFTLKSDVLFNFNKATLKPEGQQALDQLYTQLSNMDPKDGSAVVLGYTDRIGSEQYNQKLSEKRAQSVVDYLVAKGIPANKISARGMGESDPVTGNTCDNVKARAALIDCLAPDRRVAIEVKGYKDVVTQPQA
What is the function of this protein?
Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
What are the official names of this protein?
Outer membrane protein A, Outer membrane porin A.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: MOAC_BEII9
Sequence: MSSLTHLTSHGEAVMVDVSDKAETERVAIAEARVVMRMETLELALSGNAEKGDVVATARIAGIMAAKKTHELIPLCHPLLLTKVGVDLEPDPSLPGFRVQALAKVKGQTGVEMEALTAVSVACLTLYDMLKAVDRFMRIEGIGLLEKQGGKSGSWKREKE
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: NUOH_PSYA2
Sequence: MQVTRIIPDVPSFLASMMTFDTWSILFMVVQSLVIFLVVVIVAAMMIIYERRMLALWQDRYGPNRVGPFGSLQLVADMLKIFFKEDWTPNFTDKFMFTLAPAVAMFTALASFAIIPISPTLGVADWDIGILFFFAMAGIAVYAVLFGGWASANKFSLLGGLRSAAQTISYEVFLGLSLMGVVALTGSFNLRAIVEAQADGWYIIPQFFGFLTFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYSGMKFGMFFIGEYVNVVLISALMTCLFFGGWLAPFNLDIPFIPPAFWFMIKTLFFMTMFILARGSLMRPRYDQVMNFGWKVCLPVTLINLLVTAAVILIFSPTL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_PSEAB
Sequence: MSESAPTPRRERVIVGMSGGVDSSVSALLLLQQGYQVEGLFMKNWDEDDGTEYCTAREDLADAQAVCDRIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYALMLGADLIATGHYVRRRDRDGRTELLKGLDPNKDQSYFLHAVGGEQIARSLFPVGELEKPEVRAIAEKHGLATAKKKDSTGICFIGERRFTDFLKQYLPAQPGDIETTEGKVIGRHSGLMYHTIGQRQGLGIGGLKEAGDDPWYVLGKDLQRNVLLVGQGNDHPLLFSRALLASRIYWVNPVELERPRRLRAKVRYRQSDQDCVLEKTAEGYRAVFDEPQRAVTPGQSVVFYDGDVCLGGGVIETAEAWDFGGRP
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPE_SHESA
Sequence: MTINALLLSSSRVGDTPYLSHALPFIKPLTANAQKWIFIPYAGVSMSYDTYLASVVAGLSELRLDISGIHQHPDPRQAIKDADGILIGGGNTFHLLHELYKYDLVHLIREEVQNGKPYIGWSAGSNVSGLSIRTTNDMPIIEPPSFTALNIVPFQLNPHYSNYRAPGHNGETRAQRLLEFTRVDPITPVVGIVEGSALWRQGDTLSLLGDNPAYLFCGEQQEIPIPVGSDLSHLLK
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIF1A_RAT
Sequence: MEGAGGENEKKKMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKAPDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTSSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKDSQPQCIVCVNYVVSGIIQHDLIFSLQQTESVLKPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYNDVMFPSSNEKLNINLAMSPLPASETPKPLRSSADPALNQEVALKLESSPESLGLSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSAQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSPSPPSVSTVTGFQQTQLQKPTITVTAATATTATTTDESKAVTKDNIEDIKILIASPPSTQVPQEMTTAKASAYSGTHSRTASPDRAGKRVIEKTDKAHPRSLNLSVTLNQRNTVPEEELNPRTIALQNAQRKRKMEHDGSLFQAAGIGTLLQQPGDRAPTMSLSWKRVKGYISSEQDGMEQKTIFLIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
What is the function of this protein?
Functions as a master transcriptional regulator of the adaptive response to hypoxia.  Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.  Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity).  Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).  Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300.  Activity is enhanced by interaction with NCOA1 and/or NCOA2.  Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.  Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity).
Protein: S41A1_DANRE
Sequence: MVLWLKDQDKLSDMSTGTERIEMKKEGVPPAYHHSNGSVHPVILPDSPEEVPQTPGEYELTEVTSLPDCGDQENERPDMVVLDCRANAKGQREEDALLENASQSNESDDTSTDQSPVPPAPLKETSFSIGLQVLIPFLLAGFGTVAAGMVLDIVQHWTVFTEVTEVFILVPALLGLKGNLEMTLASRLSTAANIGQMDTAKDMWKMIMGNLALIQVQATVVGFLASIAAVIFGWIPEGNFRMGHAILLCASSVATAFIASLALGLIMIGVIIASRKVGINPDNVATPIAASLGDLITLSLLAGISTGLYKELEFNNYANPMVCAFFVALTPIWVLIARRIPSTREVLYSGWEPVIIAMAISSVGGLILDKTVSNPNFAGMAVFTPVINGVGGNLVAVQASRISTYLHMNALPIVEPNPAPRKCPTPWGTFFGSGVNSRSAKVLFLLVAPGHLVFLYTINSMRGGHTTLTYIFIAFYLAAALLQVIILLYLADWMVNWMWRRGMDPDNFSIPYLTALGDLLGTGFLALCFHILWLIGDRDTDVGD
What is the function of this protein?
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (By similarity).  Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (By similarity).
What are the official names of this protein?
Solute carrier family 41 member 1.
What is the protein family that this protein belongs to?
Belongs to the SLC41A transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: HIS7_BURTA
Sequence: MRVAEVVRNTSETQIRVKIDLDGTGRQKLATGVPFLDHMLDQIARHGLVDLDIEAHGDTHIDDHHTVEDVGITLGQAVAKAVGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQLETVFKAFGRALRMAVELDERAAGQIPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXCR2_RABIT
Sequence: MQEFTWENYSYEDFFGDFSNYSYSTDLPPTLLDSAPCRSESLETNSYVVLITYILVFLLSLLGNSLVMLVILYSRSTCSVTDVYLLNLAIADLLFATTLPIWAASKVHGWTFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTMIQKRHLVKFICLSMWGVSLILSLPILLFRNAIFPPNSSPVCYEDMGNSTAKWRMVLRILPQTFGFILPLLVMLFCYVFTLRTLFQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLTDTLMRTHVIQETCERRNDIDRALDATEILGFLHSCLNPIIYAFIGQKFRYGLLKILAAHGLISKEFLAKESRPSFVASSSGNTSTTL
What is the function of this protein?
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor.  Binding of IL-8 to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.  Binds to IL-8 with high affinity.  Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
What are the official names of this protein?
C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_BRASB
Sequence: MRILCTNDDGIHAPGLKVIEEIARALSDDVWIVAPELDQSGVSHSLSLNDPLRLREVGPRHFAVRGTPTDCVIMGARHILGAKLPDLVLSGVNKGRNVAEDVVYSGTIAGALEGTILGLPSFALSQEFSIATRDKPSWDTALKFGPQIVRKVLEAGVPRNTVINVNFPACAPDEVKGLVVTRQGKRNLGFLKVDERRDGRGNPYFWIGFDRAAALDVPDEGTDLAALAARYVSVTPLRLDRTDEAFSGKLTTILG
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH_LEPCP
Sequence: MKKIKCALIGPGNIGTDLLAKLQRSAVLEPVWMVGIDPESDGLKRAREMGIKTTSDGVDGLIPHMKADGVQIVFDATSAYVHAENSRKVNEQGALMIDLTPAAIGPFCVPPVNLKAHVGSGEMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSRSVGPGTRKNIDEFTRTTAGAVEKVGGARKGKAIIVINPAEPPLMMRDTVHCLTETEPDQAAITASVHAMLAEVQKYVPGYRLVNGPVFDGNRVSVFLEVEGLGDYLPKYAGNLDIMTAAAARTAEMFAEEILKGELVLQPTAVAA
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.