PharMolix/UniProtQA huggingface dataset:
Protein: NMNA2_RAT
Sequence: MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQHENTQPIYQNSNVPTKPTAAKILGKVGESLGRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADADRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG
What is the function of this protein?
Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity).  Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).  Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP.  Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency.  Cannot use triazofurin monophosphate (TrMP) as substrate.  Also catalyzes the reverse reaction, i. e.  the pyrophosphorolytic cleavage of NAD(+).  For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively.  Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+).  Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (By similarity).
What are the official names of this protein?
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon. Note=Delivered to axons with Golgi- derived cytoplasmic vesicles.
Protein: NADK_BURCJ
Sequence: MKTGNQFNTVALVGRSNTPGIAEPLATLADSIATLGFEVVFEGDTAREIGIAGYPALTPAEIGARADVAIVLGGDGTMLGIGRQLAPYRTPLIGINHGRLGFITDIAASDMQALVPVMLAGKFEREERSLLEARIVRDGEPIYHALAFNDVVVNRSGFSGMVELRASVDGRYMYNQRSDGLIVATPTGSTAYALSSAGPILHPQLAGIVLVPIAPHALSNRPIVLPDDSKIAIQIVGGRDVNVNFDMQSFTSLELNDTIEVRRSKHTVPFLHPIGYSYYTTLRKKLHWNEHASNEDDKAS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFL8_MOUSE
Sequence: MEPGLQQAGSCGAPSPDPAMQVQPGSVASPWRSTRPWRSTSRSYFYLSTTALVCLVVAVAIILVLVVQKKDSTPNTTEKAPLKGGNCSEDLFCTLKSTPSKKSWAYLQVSKHLNNTKLSWNEDGTIHGLIYQDGNLIVQFPGLYFIVCQLQFLVQCSNHSVDLTLQLLINSKIKKQTLVTVCESGVQSKNIYQNLSQFLLHYLQVNSTISVRVDNFQYVDTNTFPLDNVLSVFLYSSSD
What is the function of this protein?
Cytokine that binds to TNFRSF8/CD30.  Induces proliferation of T-cells.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 8, CD30 ligand, CD30-L.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: CYOB_BUCAI
Sequence: MFGKLTFDAIPYHEPIIMITYIAIILIALCIASTITYYKKWKYLWYEWFTTVDHKKISIMYGILAFVMLFRGFVDAILMRTQQVVASAGFKGFLPPHHYDQIFTAHGVIMIFFVAMPLVIGLMNLVIPLQIGARDVAFPFLNNLSFWLNVSSAVLLTLSLGIGEFAQTGWLAYPPLSGIKYSSGVGVDYWIWSLQISGVGTTLTGINFLVTILKMRAPGMSFFKMPVFTWTSLCTNILIVISFPVLTVTLVLLTLDRYFNFHFFTNDLGGNAMMYVNLIWIWGHPEVYILVLPVFGVFSEVVATFSKKRLFGYVSLVWATLSITILSFIVWLHHFFTMGAGADVNTFFGITTMIIAIPTGVKIFNWLFTIYQGRVHMHSSILWTLGFLVTFSIGGMTGVLLSVPPADFVLHNSLFLVAHFHNVIIGGVVFGCFAGINYWFPKLFGFVLNEIWGKRAFWFWIIGFFLAFIPLYFLGLMGMTRRLSQNIDSEFHMLLCIAAIGACFIGIGIICQVIQFFISIKERRHNLDLTGDPWDGRTLEWSTSSPAPLYNFAIIPKVEDRDDFWRNKEGQHYNKLINSINYHDIHMPKNTGLGFMISIFSLFFGFSAVWHITWLCILSFLAIIISLFINSLNEDTEYTISAEEIKKIEHQYWKNIQKAGLK
What is the function of this protein?
Cytochrome bo(3) ubiquinol oxidase is the terminal enzyme in the aerobic respiratory chain.  Catalyzes the four-electron reduction of O2 to water, using a ubiquinol as a membrane soluble electron donor for molecular oxygen reduction.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron and generating a proton motive force.  All the redox centers of this enzyme complex are located within the largest subunit, subunit I.  Protons are probably pumped via D- and K- channels found in this subunit.
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 1, Cytochrome o ubiquinol oxidase subunit 1, Cytochrome o subunit 1, Oxidase bo(3) subunit 1, Ubiquinol oxidase polypeptide I, Ubiquinol oxidase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEMA_INBBK
Sequence: MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPNCLNCTDLDVALARPMCIGTIPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAERAPGGPYRLGTSGSCPNVTSKSGFFATMAWAVPRDNKTATNPLTVEVPYICTKGEDQITVWGFHSDNKNQMNKLYGDSNPQKFTSSVNGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: EFTU2_ECOHS
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLS
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WZZB_SHIFL
Sequence: MRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSDLQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDIEKLKFDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK
What is the function of this protein?
Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS).  Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules.
What are the official names of this protein?
Chain length determinant protein, Polysaccharide antigen chain regulator.
What is the protein family that this protein belongs to?
Belongs to the WzzB/Cld/Rol family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PT122_LACK1
Sequence: MIPTFRIQIRRYLNTEVKRRLYAQCLNRDFDSLLAEVKGIPVSEMEESFVTLYLMKSAQFGHVPSLDYLWHKYVMRHHMIMVNPSLLCDIGNIALQEGKLFIPEQLSSHFMKFYGSNNEYEQYRYELLRIQVESFAKGTMEKTSFREKWKVFLQDLDHTVERDFQFSVRDFPHLTQALSGTDRELLLKMLFSEGKISVCNNSSLPMLLNMILLQEEFELEFKIKLFQNFYTIHRHLNYEDTVTILFKNCKGNGYRSIELMEFVRGNKITTPHLAYKYFLQSIIDSEYYFKAYDYMDLVKKYDGLLEQLRQQE
What is the function of this protein?
Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3).  PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA (By similarity).
What are the official names of this protein?
Protein PET122, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: ALC_BPT4
Sequence: MDLQLITTEMVVEAYGDTTDGISVFKGNRRVGYITGLKKDLAKQVKRKTTIKEYRNRRLEQARDMLPDAVEEMKVFLENQLAKYDCEVFINQTQPNVHINSCKCYIIVNPLTGKHRLGISNPNRSASDMAEDVEACFKISKSPAEHHILINGLSQDDIVEVIKTLCM
What is the function of this protein?
Participates in the host transcription shutoff by causing premature termination of transcription from host DNA.  Acts as a site-specific termination factor that abolishes transcript elongation on cytosine-containing DNA but not on the 5-hydroxymethyl cytosine present in the viral DNA.  Therefore inhibits as well transcription from other phages that contain cytosine in their DNA.
What are the official names of this protein?
Protein alc, Protein unf.
Protein: RS16_DESVM
Sequence: MSVKLRLARMGNKKRAFYRIVAVNSAARRDGRPLEFLGFYNPMVNPAEVKIDTAKVQKWLDQGAEPTDTVRTLLKKQAG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: APD3_ARATH
Sequence: MGSIRGDLQPLFVMPPPPLDEDCDDIFNSDESSWGLLSLSCFGIIMGLWFFASVCLIFGVYGSETVWLGPNSSILVKPSSIFVKSIKVKELDFSKPGLQLYGFNGQSTPSGYFVNWTESRVLSVSQNSYKGWPYYLNRGTHMNISYNILPKGSAVRLVITEGSQVIGMPFFYRSSLKDIAFRDTAWSWNLIQGSGMIQLDISKSKGYYLTVANLKRKDIEVELDIDVKAVLYDTKQTSYNCSFSNGECSFKMNERYPVENYAVVTSPALGQGVSIDDEWYIELSYQPRLIAYGSFTGVLLSFMLVAIHFCNKLKCCGGEGFLSGDDSVRTCLLADKGDNDCCNDVEASNKSLCAICFDAPRDCCFLPCGHCVSCYQCGTKIKRTKGRCPICRKKMIHVKRIYTA
What is the function of this protein?
Involved in pollen mitosis II (PMII) regulation during male gametogenesis.
What are the official names of this protein?
E3 ubiquitin-protein ligase APD3, Protein ABERRANT POLLEN DEVELOPMENT 3.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein. Vacuole membrane; Multi- pass membrane protein.
Protein: ENY2_TAEGU
Sequence: MNKDAQMRATINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKDVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Transcription and mRNA export factor ENY2, Enhancer of yellow 2 transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: DPO3X_MYCGE
Sequence: MHQVFYQKYRPINFKQTLGQESIRKILVNAINRDKLPNGYIFSGERGTGKTTFAKIIAKAINCLNWDQIDVCNSCDVCKSINTNSAIDIVEIDAASKNGINDIRELVENVFNHPFTFKKKVYILDEAHMLTTQSWGGLLKTLEESPPYVLFIFTTTEFNKIPLTILSRCQSFFFKKITSDLILERLNDIAKKEKIKIEKDALIKIADLSQGSLRDGLSLLDQISNFSDSEKISITDVEKTFNIVDRNAKFTFIKAVLSGDIKEAFNLLDDFESNGLNFTYFLRELFALTVNLYAYAKLKNINVLDSTEKTMIETLNFEKQHYAFLIKAIEENTNFGLSQLTLIDRLKAIVISYNEFFNQKPLTISSPSNEKSLHLETEYLEKKKIKKSNHKQDQKHFSLFEKSFIDKSEKTPKNDEVTNNKFLDTSKLNLANIALAINAFNDNKWINHFQNLLSVFQTKFNDKDKQNNLSYFNNFIDKYSARDIVKATKIVKASSFGIVILFEDQKIAMRLWKEAIEEGNVQATIFQIFNQNLFLASFSEHQYKTTITEETKNQKYQTEVLNLTQLENLAKPFLKEKKRSLSQKMVDKYFKGLFEEK
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III subunit gamma/tau.
What is the protein family that this protein belongs to?
Belongs to the DnaX/STICHEL family.
Protein: FATE_BACAN
Sequence: MIKIDNVKKFYTDKVKIGPLDIEIPKAGFTSLIGPNGAGKSTTLLMIGRLLDMDEGQIQVANMDVSESKSKDLAKVLTILRQENHFVTRLTVRQLVGFGRFPYSKGRLTKEDEVIISKYIDFLDLTNLENRYLDELSGGQRQRAYVAMVLCQETEYVLLDEPLNNLDVARSVQMMEHLRRAANEFGRTILTVMHDINFAAKYSDKICAMKDGQIAAFGTVEEVMDSTLLTDIFETRIEIIKGPYGPIAVY
What is the function of this protein?
Part of an ABC transporter complex involved in ferric-petrobactin uptake.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Petrobactin import ATP-binding protein FatE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METR_ECOLI
Sequence: MIEVKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQALQACNEPQQTRLRIAIECHSCIQWLTPALENFHKNWPQVEMDFKSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDYEVRLVLAPDHPLAAKTRITPEDLASETLLIYPVQRSRLDVWRHFLQPAGVSPSLKSVDNTLLLIQMVAARMGIAALPHWVVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARNHACDHLPFVKSAERPTYDAPTVRPGSPARL
What is the function of this protein?
Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes.  MetR is also a negative regulator of its own expression.  Binds homocysteine as an inducer.
What are the official names of this protein?
HTH-type transcriptional regulator MetR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_ANAMF
Sequence: MRYCRLGVSSMRPKLKVRGQYIKDLSFENPNSPKVFLMISKSPPEISISVNVSSASLPVKPTEGEQAAADLYEVTLQVNIESVVEKVPAFLCELKYCGVFSLEEKAEEQVVKEALLITAPGVLFPFVREVIAKMTASAGFPPLMLDVIDFEAMYASQLGGDDGKNKQANKSGGAA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_CHLPN
Sequence: MPQKVLITSALPYANGPLHFGHIAGVYLPADVYARFRRLLGDDVLYICGSDEFGIAITLNADREGLGYQEYVDMYHKLHKDTFEKLGFALDFFSRTTNPFHAELVQDFYSQLKASGLIENRISEQLYSEQEQRFLADRYVEGTCPRCGFDHARGDECQSCGADYEAIDLIDPKSKISGVELVKKETEHSYFLLDRMKDALLSFIQGCYLPDHVRKFVVDYIEHVRSRAITRDLSWGIPVPDFPGKVFYVWFDAPIGYISGTMEWAASQGNPDEWKRFWLEDGVEYVQFIGKDNLPFHSVVFPAMELGQKLDYKKVDALVVSEFYLLEGRQFSKSEGNYVDMDKFLSSYSLDKLRYVLAATAPETSDSEFTFLDFKTRCNSELVGKFGNFINRVLAFAEKNHYDKLSYHSVVLEDSDRAFLEEVRQLVRDAEKCYREYSLRKATSVIMSLAALGNVYFNQQAPWKLLKEGTRERVEAILFCACYCQKLLALISYPIIPESAVAIWEMISPKSLENCNLDTMYARDLWKEEILDVINEEFHLKSPRLLFTTVE
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFE_SHEDO
Sequence: MSQYQEIAKQGLWHNNPGLVQLLGLCPLLAVTATVTNALGLGFATLLVLVGSNMLVSLVRDYVPKEIRIPVFVMIIAALVTSVQLLINAYAYGLYLSLGIFLPLIVTNCVIIGRAEAFASRNNLAHSAFDGLMMGIGFTCVLVVLGAGRELLGQGTLFEGADLLLGDWAKALVMQVWQVDTPFLLALLPPGAFIGMGLLIAGKNVIDARLKARQPKTQAEPVARVRITKVS
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMC_BURPS
Sequence: MTDRIVPATLVFREDGTVVSPLYGDIYHSAAGALAQADHVFIRGNGLPERWRHERAFTIIETGFGTGCNFLATWAAWRADPSHCERLHFVSVEKHPFAREDLRRAAAHIVAYTTITTITPIAPLVDELANAWPALTPGVHRLEFDDGRITLTLVFGDALDVLPNLALRAHAFYLDGFAPSKNADLWSPAIFKSLAKLADERATFATYTSSGAVKRALDEAGFAYRKVDGFAGKRAMLVGEFAPRWRVRRHEPPRAFSTDRRDAIVIGAGLAGCAVVERLAARGWHVTLIERRERIASEASGNPAGVFHPMIARDDNLAARLSRAGFLHALHRWRALERAGHAFSRSTHGLVQLATSDDEFERMRESIDALGVPAELASALSRDDARALLRTDVAHGGWLFAQGGSISPAALAAAQCAAAGDRLSRIVGVEIARLERGGDGRWRALDASGATIAQASVVVVANAADAARIAGLRHAPTQRVRGQLTLLPPGSAPAVPLPVIGDGYVVPLANGVTLTGATYEPDDTDATPREAGHRENLERLERLLPAFSANALDAGALAGRVGFRCVASDRLPLVGELGDEAAAAREAAALTGARLRDVPRATGLYGAFGYGSRGLVWAALGAELIAAQIDGEPWPLERELAEAIDPARFLVRALRHGRVA
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7A_THEGJ
Sequence: MAKPSYVKFEVPQELAEKALEAVEIARDTGRIRKGTNETTKAVERGQAKLVIIAEDVDPEEIVAHLPPLCEEKEIPYIYVPSKKELGAAAGLEVAAASVAIIEPGKARELVEDIAMKVKELMK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INS1_KATPE
Sequence: ISSQHLCGSHLVEALNLVCGDRGFFYNPRGIVEQCCHRPCSIFELENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).
What are the official names of this protein?
Insulin-1.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SLYX_VIBCM
Sequence: MSLTQLQERIEDLECKLAFQEQTIETLNDALTQQQLLLSKMQDQMKYVVGKVKNMDTSTLADPAHETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: ISPE_MICAN
Sequence: MHSYTLLAPAKINLYLEIVGDRPDGFHELVMVMQTVALCDRITLRPNGLQEFRLFCHHPLVPQDSSNLAHRAATLMAKEFPRLFANYGGIDITIEKYIPVAAGLAGGSTNAAAVLVGIDLIWELGLTRPELETLAARLGSDTSFCVTGGTVICTGRGEILDPIAPLTGLWVILAKYDHLSVSTPWAYQSYRQKFQDTYLSSPEDFHHRRQQVSSGALVQAIAQKKPAAIGKFIHNDLEKVVLPEFPLVAELRQVLGDLGGLGTMMSGSGPTVFTLCSSQEVAETIVKEAREILVAPDLQFWIAPITDTGIQVT
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MEF2B_HUMAN
Sequence: MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPSPIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASSEKTQQ
What is the function of this protein?
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes.  Activates transcription via this element.  May be involved in muscle-specific and/or growth factor-related transcription.
What are the official names of this protein?
Myocyte-specific enhancer factor 2B, RSRFR2, Serum response factor-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the MEF2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLPK_STRZP
Sequence: MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAIVWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYARDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQMDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEIDD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: Y954_STRGC
Sequence: MPEKEMKLVIVTGMSGAGKTVAIQSFEDLGYFTIDNIPPTLVPKFLQLLETTNDIDKLALVVDMRSRSFFAEIQNVLDQVENNLEIDFKILFLDAADKELVARYKETRRSHPLAADGRILDGIKLERELLAPLKNLSQNVVDTTDLTPRELRKTISEQFSDQSQQQSFRVEVMSFGFKYGLPLDADLVFDVRFLPNPYYQPELRNQTGLDKPVFDYVMNHEESTEFYQHLLNLIEPILPGYKKEGKSVLTIAVGCTGGQHRSVAFAQRLADDLAKNWPVNCSHRDKDRRKETVNRS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein SGO_0954.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.