PharMolix/UniProtQA huggingface dataset:
Protein: EAF7_SCHPO
Sequence: MSSRGTRSSTAAEQKRQEDVNKESNMNDSVTEWSVLEETLLLKAICRGLRPVGIEKNFYMIGILREIRDGCKRSTIKAQDVWNKLGTLYNLKEFEELEAPGNEEVKAKEKRIKSPDVKDFKLPKDILKVKEKSEKPLETSQKVEIETVETKPGEPEVKQETNLQKEKKESKVKLESKEEKISRNLRSSSRSISPVTEQPQSPKIQPVIPEKKEKSEKKESSMTLRKRSVSPSSQNTARSPKRMATEPIEPASSPAASNQAIRRSSRSRRPPT
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Probable chromatin modification-related protein eaf7.
What is the protein family that this protein belongs to?
Belongs to the EAF7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TYSY_ROSDO
Sequence: MQQYHDALRTILECGEESTDRTGTGTISYFGMQMRYPLSDGFPLVTTKKLHLRSIFHELLWFLSGDTNIRYLQDNGVSIWDEWADENGDLGPVYGHQWRAFSALSPTEEVKDGEPLYLGRGVDQVTNLIDMIKSSPDSRRMIVSAWNPADVPRMALPPCHALWQVRVLNGRMHLQLYQRSADMFLGVPFNIASYSLLLVMLAHVTGYEPGDFVHTLGDAHIYSNHMDQVNLQLTRTPKPLPTLRINRQVSSIFDFRYEDFEVIGYDPDPAIRAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_STAA9
Sequence: MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_ECOUT
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_XYLF2
Sequence: MRLSEFHLHTTKEIPADAELVSHRLMLRAGMIRKLASGLYTWSPLGLRVLRKVEAIVRDEMNRAGAVEMLLPTIQPRELWEESERWEKFGSQLLKIKDRKQAEYCYSPTAEEAVTDYVRQELTSYKQLPVNLYQIQTKFRDEIRPRFGVMRAREFVMKDAYSFHLNDADLVREYENMRATYTRIFTRLGLEFRAVQADSGAIGGDASQEFHVIADSGEDVLAFSTGSDYAANIEAAIAATPGPRLTANETLQKVSTPTQKRCEDVAALLDIPLQRVVKSIAVMTDSGFFLALLRGDHTLNDIKLSKLPGLANFRLANEVEIARHLGSEPGFLGPVCPGMPIRIIADCEVAVMADFVVGANEVGFHLVGVNWGRDLPEPEVVADIRNVIEGDRAVDGGKICIARGIEVGHVFQLGRKYAEAMKATVLDEYGKAVTMTMGCYGIGVSRIVAAAIEQNHDVAGIIWPAPIAPWQVAVCVINPKKDPVITAAAEMLLAELQSADVDTVLDDRGLRPGVMFADMELIGIPHRIVVSERGLAAGTYEYRARRTAMVENLDKTTLLTRIKA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSBW_BACCQ
Sequence: MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYKEDVGEIAIVFGLYEDRLEIMVADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLINTLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYNSY
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: KDPA_YERP3
Sequence: MAASGFLLIASFMVVLFVLSRPLGGFLARLIEGEPFSALQKVEAGLWRCSGVKNAEMNGWQYALAILCFNLLGIVLLFVLLMAQGSLPLNPEHLPGMSWHLALNTAVSFVTNTNWQAYSGENTLSYLSQMAGLTVQNFLSAATGIAVAFALIRAFARHSATTLGNAWVDLVRITLYVLLPIALIIALIFVSQGVLQNLDGYLHITTLEGVQQTLPMGPVASQEAIKVLGTNGGGFFGANSAHPFENPTAFSNFVQMLAIFLIPCALCFAFGQVVGDNRQGHALIWAMSLIFIVAVVVVMYAELAGNPHLSPLGADSNSNMEGKESRFGILATSLYAVVTTAASCGAVNAMHDSFTALGGMIPLWLMQIGEVVFGGVGSGLYGMLLFVLLTVFIAGLMIGRTPEYLGKKIDVFDMKMTALAILVTPTIVLLGTALALCTEAGRAGILNPGAHGFSEVLYALSSAANNNGSAFAGLSVNTPFYNLLLAAAMFIGRFGVILPVLAIASSLVAKKRQPAGNGTLPTGGPLFIGLLIGTVLLVGALTFIPALALGPVAEHLQVWLAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS4_ROSS1
Sequence: MARYRGPVGKVSRRLGIGITDKGQRILAKRPFPPGQHGPSARRRQVSDYGLQLLEKQKARYVYGVLERQFRRIFEKAQRFPGETGAYLFILLERRLDNVVYRLGFATTRAQARQLVSHGHITVNGRKTNIPSYTVRVGETIAVRPESRRRTYFKNLIDSGALARHKTPDWLRLNPADLSGEVVAMPRREDAEPGINEQLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RR7_CHLVU
Sequence: MSRRRTQKKRIVMPDPVYDSRLVELLVRQLMREGKKSLAYRICYESMNRVADATQQDPLVIVEQAIRNATPLVEVKARRIGGSTYQVPLEVASERGTALAIRWILSVCRKKTGRPMAAKLTAELLDAAKNSGLAVRKRDEIHKMADANKAFAKYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MRP9_HUMAN
Sequence: MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL
What is the function of this protein?
Probable transporter, its substrate specificity is unknown.
What are the official names of this protein?
ATP-binding cassette sub-family C member 12, Multidrug resistance-associated protein 9.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PUR9_PROMM
Sequence: MAPIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEILGGRVKTLHPRVHGGILAMRGDPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETAIENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSDGVDDQLRRELALEAFEHTAAYDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKELSTNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALDADRVSAFGGIVALNGLVDATTARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPGAIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSPNAEENADLTFAWRLVRHVRSNAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHGICAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: Y4UA_SINFN
Sequence: MEKCSHESGRHSAENDGKYDITGSTATNVVDGFTMVAVGDVIVSRALANGHHPGFSEIVELLRAADVTFGNMETLIFDIRSFNGTPQAEYGGAYHVSLPEIGPDLKAMGFNIMGRANNHSLDWGVEGMRETSRILDESGIIHAGVGESRAQASAARLLETARGRVALLSCATSFTPMSRACDPAGEAPARPGVNALRLERSVVVEPDMLESLRKIRDALPNPGPKHDDREMLVLAGTTYRTGKDVGYTYAANTRDLADILRNVRRGKQYSDFCIFTNHAHEPGNWSEEPADFEQALARKLIDAGADAYVGHGPHRLRGIEIYKRRPIFYSLGNFFYDDLRTPVGADMYDVYDKDPQVDTDAEVTAAEETMGYPTAAGFIGALAEPVYYESVVAVSRFEENQLAELRLYPIELGYSKRLANRGVPSLAPRPQAISILERLQRLSEPFGTRITIEDRVGLIRL
What is the function of this protein?
Could be involved in the biosynthesis of a cell wall component.
What are the official names of this protein?
Uncharacterized protein y4uA.
What is the protein family that this protein belongs to?
Belongs to the CapA family.
Protein: ANM7_MOUSE
Sequence: MKVFCGRANPTTGSLEWLEEDEHYDYHQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRCLVAHHDDYCVWYSLQRTSPDENDSAYQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYAQALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDSTISTGLINPAEDKGDCCWNPHCKQAVYFLSTTLDLRVPLNGPRSVSYVVEFHPLTGDITMEFRLADTLS
What is the function of this protein?
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA.  Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles.  Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s.  Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites.  May also play a role in embryonic stem cell (ESC) pluripotency.  Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity).
What are the official names of this protein?
Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: KHSE_ESCF3
Sequence: MVRVYAPASSANMSVGFDVLGAAVTPIDGSLLGDVVGVEAADSFSLQNLGRFASKLPSKPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEYCGKPLNDTRLLAIMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPLLAAKLMKDVIAEPYRERLLPGFSQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVAEWLAKNYLQNQEGFVHICRLDTAGARVLE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_NITHX
Sequence: MIASVVTRFAPSPTGFLHIGGARTALFNWLYARKHGGKMLLRIEDTDRARSTTAAIEAILDGLKWLGIDWDDDVVYQFSRVARHRDIAEQLLAEGKAYRCYATPEELAEMREKARAEGRAKLYDGRWRDRDPSEAPPDLKPTIRLKAPLSGETVIEDQVQGRVVWQNENLDDLVLLRGDGTPTYMLAVVVDDHDMGVTHIIRGDDHLINAARQKQIYDTLGWALPTMAHIPLIHGPDGSKLSKRHGALGVDAYRAMGYLPAALRNYLVRLGWSHGDQEIFSTQEMIDAFDLSAIGRSAARFDFAKLENLNGHYIRNCDDHVLVDLFQDALDYVPRGADLKPKLNDATRAQLLRAMPGLKERAKTLIELIDSARFIFADRPLTLDAKAIPLLTSETRALIGRLRTTLETVTSWSAQTTEAAMRTFAEQNNLKLGAIAQPLRIALTGRTTSPGIFDVLAVLGKETCLARLDDQSSP
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSEP_SALTY
Sequence: MLSILWNLAAFIIALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRYGTEYVIALIPLGGYVKMLDERAEPVAPELRRHAFNNKTVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVIGEITPNSIAAQAQIAPGTELKAVDGIETPDWDAVRLQLVSKIGDQQTTVSVAPFGSDQRQDKTLDLRHWAFEPDKQDPVSSLGIRPRGPQIEPVLSEVQANSAASKAGLQAGDRIVKVDGQPLTQWMKFVTFVRDNPGKPLALEIERQGSALSLTLTPDTKSVNGKAEGFAGVVPKIIPLPEEYKTIRQYGPFSAILEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAQGAGMSAEFGVIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL
What is the function of this protein?
A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA.  Part of a regulated intramembrane proteolysis (RIP) cascade.  Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA.  This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA (By similarity).
What are the official names of this protein?
Regulator of sigma E protease, S2P endopeptidase, Site-2 protease RseP, S2P protease RseP, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_ACTPJ
Sequence: MATINQLVRKPRVKKVVKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRIRLTNGFEVTSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGALDCAGVKDRKQGRSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: NU1M_COTJA
Sequence: MTLSTLTSLMIMTLSYMIPILIAVAFLTLVERKILSYMQARKGPNIVGPFGLLQPIADGVKLFIKEPIRPSTSSPFLFILTPILALLLALTIWTPLPLPFPMTDLNLGLLFLLAMSSLTVYSLLWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSTIMLSGNYTLSTLSITQEPMYLIFSSWPLTMMWYISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFLAEYANIMLMNTLTITLFLNPSFLSPPSELFSITLATKVLLLSSSFLWIRASYPRFRYDQLMHLLWKNFLPLTLAMCLWHTSMPISYAGLPPA
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DPO3_MYCPU
Sequence: MQESFLNFCQEINFDIPEYLKNTKIANPYHDEEKSFFSCEIDFLETPKFEDFKSFYLKTKNFLNQLVKEQKLLFKIENIFYEKSEIKKYLDWIAEHFFKNFDFKNTFRIDDLKVNLDGKIFLTAHSKHSFDLYKDFVEFANKKMQSFGFENFLLKLELNQIEITNNQPLVSSINSQVKTQASSENQSFKKSNFYNKKRHIQLSLKELIKTQEMFVSVVGMVFKKEIITTNSKTKIFKISITDFQEATRAQKFSYLEKDQEIFDSIQINDWVNVCGEIQLEKMSLKQFIKIEKIEKIRSPIKDRQDNEKEKRIELSFRSKMSTMDGILSPLDIVKQAKKFNHSSIAILDHNSVQAFPDFHNLTYKDKDFKVIYGMTLSVISKRNKIFVEPLKDKFFDYKILDQEYVVYDIETTGLSPMLNELIQFGASVIKNGRIIETHHFFIKPKSKLDSFTTKLTGITQEHLEKGYELQEALEKISSIFKARIMVAHNAAFDHNFLKQKFIDNNIEFEEMISIDTLNLAKVLNPIYRSYRLGEVASKLSVVYDPSIAHRADYDSSVLTNIFILQMSHLKEKGINLFKELNSLSSEKFYSKMFAKDISIIAKNQAGLKELFKINSDVLTKYYFANPKMFWEDIKRSKNLLIGSGGLNSPLIDKLLFSTQEDVLNEIDKYDYIEIPSPNNFSHFWTTKFSDQQIKIQLQKLIKWAKEKNKIIVAIGEPRYNEKWQKIIHEIYINSTGIENSLHPLFIIKKDMDTFYPEQIYKTTNEMKQEFSFLYDPELIEEIVVKNPNLISSQIEKIQVIKDKLYTPKFDDSHIKLKKLVYENAWKKYGKNLPEIIEQRIEKELTPILNYGFDVIYWISSILVQKSLSDGYLVGSRGSIGSSLVATLSGITEVNPLAPHYICSKCQYFELVKDPMTNSGFDLDDKKCPKCNSFLDKDGQTIPFETFLGFKADKVPDIDLNFSGEYQGKIHDEVKRLFGSKHTFRAGTISTVAEKTAYGYIKKYLETASLDYSDNFVDFLTEKSTGVKRTTGQHPGGIIIIPKEFDVEDFTPVNFPANDTESSWKTTHFDFHAIHDNVLKLDILGHDDPTALKMLEKLTGVNVKDIPKKDEKIISIFTSPKALGISSEEILGEKTGALGIPEFGTNFVRQMLSEAKPKTFADLVSISGLSHGTDVWINNAHYIIQSLGKTLDQVISCRDDIMVDLIKKGVPIDLSFTIMEQVRKGKGLSLEQKRKLIEHGIENWYIESMEKIKYMFPKAHATAYVLMAWRVAFYKVYYPLEYYATYFSTRTEFFDIEIMSKDKLTLESKIKELAYRENLRNDNQLTTKEKNTLPTLYIANEMKARGFNIQNINLKISLANDWIIDKNSKSLIPPFNVIDGLGETLAQKIVDSRNEKEFLSVEDFINRTGINSTLVEKFKSMGIFEQIPETNQIFLI
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAN33_PROMM
Sequence: MSEEQLKAFIAKVQGDSSLQEQLKAEGADVVAIAKAAGFTIKQQDLNAAASELSDEELEAASGGGDTGIQAVLHTAGCYGGTKMCRA
What is the function of this protein?
Lanthionine-containing peptide (lantipeptide) with unknown function (Probable).  Does not show antibiotic activity against Lactococcus lactis 117 and Bacillus subtilis 6633 bacteria (By similarity).  Organisms that produce this peptide live in oligotrophic environments at very dilute concentrations, suggesting this peptide is not secreted to influence other bacteria (Probable).
What are the official names of this protein?
Lantipeptide prochlorosin 3.3, Lantipeptide Pcn3.3.
What are the subcellular locations of this protein?
Secreted.
Protein: RS21_SHEWM
Sequence: MPIIKVRDNEPFDVALRRFKRSCEKAGILADVRAREFYEKPTTARKRAKAAAVKRLAKKLSRENARRVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CYB_MICTW
Sequence: MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTATAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGVYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMAFMILTLFFPDILGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALMPLLHTSKQRTLTFRPITQTMYWILVADLLILTWIGGQPVEYPFITIGQTASIAYFAIIVIFMPIAGMIENNILDLD
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUP37_DROME
Sequence: MRSVIEPDHSIQLNEAIYCYDICTNDFAYNLIAVAFRKHLSLLLVGLPEESGEFGYTRLQDMDLGEKEQRSVSALAFSPDTSLNCTPNNVTLCAANGSQLKLYRTDLGQFTSLQVLRGHGDYVNDVSWVCDGELLASVSDDFTCRFWTTTGGGENVITFGLSSAGMSVKSHPEDPNKVLVAEKKGIIHLYNVTLKQTVISVESPKFPLMSADWAHSNRLFITSLAGGDVVTWDLNRPYVPADVKQVHEDCGRVVRFAPGSSEMVIAMVIGLTLKVFAAKSTVPLLEASLKSYGGMAWHQRLPYISAVSDRKLLFWKVQMK
What is the function of this protein?
(Microbial infection) Required for optimal replication of E. chaffeensis.
What are the official names of this protein?
Nucleoporin Nup37, 37 kDa nucleoporin.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex.
Protein: TPMT_SHEPA
Sequence: MQPSFWHDKWDAQQVGFHLSAVNPLLVKYWPQLELDANAQVFVPLCGKSLDMCFLAEQGHEVLGCELNELAVQQFYRENELAFDISTLAEHQRFHTEQVTIYQGDIFSLDAAEMPNTQAFYDRAALIAWPEEMRSAYARQLAKLVPANSTGLLITLDYPQAELNGPPFAVSDDWVQANLATDFEIERLSSEDVLSENPRFVNKQVSWLTESVYKLIRKG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.