PharMolix/UniProtQA huggingface dataset:
Protein: H2B3_CAEEL
Sequence: MAPPKPSAKGAKKAAKTVSKPKDGKKRKHARKESYSVYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIASEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2B 3.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PYRC_EHRCJ
Sequence: MYKQSWKLLGRGQDADFTVAYINARIIDPESKLDIIGSLLTKGDKIVDFGQDLFNNGIPSTIDEVVDCNNNILMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGVTTVVCQPNTIPTISSIITAKYIKMRALESAYVNIEFYASITKPDNSLSDMALLKEAGAVGFTDDGMPVMNSLTMRQALSYSSMLDTVVAQHAEDLNLSNNGHINEGTVSYELGLKGIPDISESIIVNRDIALMKNIKNVHYHILHVSSQDSLNIIKQAKNQGLKVTCEVTPHHLTLTEQDVITHGTLAKINPPLRTENDRLSMVEGLKNGIIDCIATDHAPHEVNTKELPLDTAAFGIVGLETMLPISLELYHNGTISLIDLLATLTYKPANIIKVPRGRIKKGFVADLIILDLNHEWTIDILKFASKSKNSPFHNRKVKGKVLRTIVSGKTTYTAVRNI
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: NANA_ARATH
Sequence: MYINTLFWKQNPTGDKKNQEEKMQKTLLSCLITTLLLITVADSMKDTSVRLKLAHRDTLLPKPLSRIEDVIGADQKRHSLISRKRNSTVGVKMDLGSGIDYGTAQYFTEIRVGTPAKKFRVVVDTGSELTWVNCRYRARGKDNRRVFRADESKSFKTVGCLTQTCKVDLMNLFSLTTCPTPSTPCSYDYRYADGSAAQGVFAKETITVGLTNGRMARLPGHLIGCSSSFTGQSFQGADGVLGLAFSDFSFTSTATSLYGAKFSYCLVDHLSNKNVSNYLIFGSSRSTKTAFRRTTPLDLTRIPPFYAINVIGISLGYDMLDIPSQVWDATSGGGTILDSGTSLTLLADAAYKQVVTGLARYLVELKRVKPEGVPIEYCFSFTSGFNVSKLPQLTFHLKGGARFEPHRKSYLVDAAPGVKCLGFVSAGTPATNVIGNIMQQNYLWEFDLMASTLSFAPSACT
What is the function of this protein?
Aspartic proteinase that can use azocasein as substrate and regulates endogenous sugar levels (e. g.  sucrose, glucose and fructose) by modulating starch accumulation and remobilization (PubMed:22987884).  Influences general morphology and development (PubMed:22987884).
What are the official names of this protein?
Aspartic proteinase NANA, chloroplast.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RECR_BIFA0
Sequence: MALAYDGAIQRLIDSFASLPGIGPKGAQRIAFYLLQAPDAESQRLVDAINEVKEKVRFCEVCGNVCESSPCTICSDPRRDHGTICVVEEPKDVMSIERTREYRGLYQVLGGAINPMANVGPSDLNIAQLLNRLHDGEVKEIIVALNPNIEGEATTTYLSRLLAPLDIKVTRLASGLPVGGDLEYADEITLSRALEGRREV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NDUS3_ACACA
Sequence: MGLNFFMSRKIYYIKLLTGLYKKFIKALIVKKNESNNAYLLVETANFYNLVFSLQRSSLTQFKVLNDVCIVDYPEKIDRFELSYNLSSIKYNFRIFIKTYTSAYVPSISTLFNSANWIERECWDMFGVFFTNHPDLRRILTDYGFEGFPLRKDFPLTGYIEIRYDDEKANIVYEPLELSQEYRLFNFTSPWEKIK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase subunit 9.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: AAMAT_AMAPL
Sequence: MSDINATRLPIWGIGCNPCVGDEVTALITRGEA
What is the function of this protein?
Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:24613547).
What are the official names of this protein?
Alpha-amanitin proprotein.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: TSN1_ARATH
Sequence: MATGAENQWLKGRVKAVTSGDCLVITALSHNRAGPPPEKTITFSSLMAPKMARRGGIDEPFAWESKEFLRKLCIGKEVAFKVDYKVEAIAGREFGSVFLGNENLAKLVVKTGWAKVREPGQQNQDKVSPYIKELLQLEELAKQEGYGRWSKVPGAAEASIRNLPPSAIGDSAGFDAMGLLAANKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGVQAPSMGRRTTNGSVVETVPDEPNGDVSAESRGPLTTAQRLAASAASSVEVSSDPFATEAKYFTEHRVLSRDVRIVLEGVDKFNNLIGSVHYSDGETVKDLGLELVENGLAKFVEWSANMMEEEAKKKLKAAELQCKKDKVKMWANYVPPATNSKAIHDQNFTGKVVEVVSGDCLIVADDAVPFGSPAAERRVCLSSIRSPKMGNPRREEKPAPYAREAREFLRQRLIGKQVIVQMEYSRKVTQGDGPTTSGAADRFMDFGSVFLPSAAKADSDEVTAPPAAAIAGSQPVGVNIAELVLVRGFGNVVRHRDFEERSNHYDALLAAEARALAGKKGIHSAKESPAMHITDLTVSAAKKAKDFLPSLQRIRRIPAVVEYVLSGHRFKLYIPKITCSIAFSFSGVRCPGRGEPYSEEAISVMRRRIMQRDVEIEVETVDRTGTFLGSMWESRTNVATVLLEAGLAKMQTSFGADRIAEAHLLEQAERSAKNQKLKIWENYVEGEEVSNGNTNTVETRQKETLKVVVTEVLGGGRFYVQSAGDQKIASIQNQLASLSIKDAPIIGSFNPKRGDIVLAQFSLDNSWNRAMIVTAPRAAVQSPDEKFEVFYIDYGNQETVPYSAIRPIDPSVSAAPGLAQLCRLAYIKVPSLEDDFGPEAGEYLHTVTLGSGKEFKAVIEERDTSGGKVKGQGTGTEFVVTLIAVDDEISVNAAMLQEGIARMEKRQKWGHKGKQAALDALEKFQEEARKSRIGIWQYGDIESDDEDTGPARKPAGGRR
What is the function of this protein?
Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress (PubMed:25736060).  Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e. g.  salt and heat) (PubMed:25736060).  Involved in gibberellic acid (GA) biosynthesis (PubMed:25205572).  Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway (PubMed:20484005).  Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA.  Binds GA20OX3 mRNA (PubMed:25205572).  May inhibit the degradation of mRNAs involved in stress adaptation (PubMed:26237081).
What are the official names of this protein?
Ribonuclease TUDOR 1, AtTudor1, TUDOR-SN protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Accumulates heterogeneously in the cytosol, in patches around the nucleus and in the cell periphery, and relocates transiently to a diffuse pattern in response to salt stress (PubMed:20484005). Accumulates in cytoplasmic stress granules (SGs) and processing bodies (PBs) in response to abiotic stresses (e.g. salt and heat) (PubMed:25205572, PubMed:25736060).
Protein: PRMA_VIBCH
Sequence: MPWIQIKLNATNDNAEAIGDMLMEETGAVSVTFLDAKDTPVFEPLPGETRLWGDTDVVALYEADMDTSLILQQIKASNMLAEGFAHKVEQVEDKDWEREWMDNFHPMQFGRRLWICPSWREVPDPQAVNVMLDPGLAFGTGTHPTTALCLEWLDNLDLSGKTVIDFGCGSGILAIAAIKLGAAKVIGIDIDPQALLASKDNAARNGVEDQIEVYLPKDQPEGLVADVVVANILAGPLRELSPIIKGLLKPGGQLAMSGILDTQAESVAEFYRDDLELDPIAEKSEWCRISGRKLG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_KARMG
Sequence: MESNNYINFFFKKKKYTKSVADVRNIYCSPRKLRLVADIIRNKKVEYSLFILKNIKNKGGGIIYKILLSVISNWKNYENNINNYNIYIEKVLINQGYQLKKIRPGPQGRGNKVRKRYSNLKIIINSKFNNYYGT
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: AC78_NPVAC
Sequence: MNLDVPYYRLGNHEKVEYIPLKLALNDDTASEPQQFSEPVHKMPINDMVGYDNTTSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQQYSDSIDTDSPFVFNKFD
What is the function of this protein?
Plays an essential role in budded virus production and occlusion body formation.
What are the official names of this protein?
Protein AC78.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Virion. Note=Envelope structural protein associated with both budded viruses (BV) and occlusion-derived viruses (ODV).
Protein: SPC98_YEAST
Sequence: MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRAKIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLIRLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKLFATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEASNGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR
What is the function of this protein?
Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB).  Probably part of the microtubule attachment site at the SPB.
What are the official names of this protein?
Spindle pole body component SPC98.
What is the protein family that this protein belongs to?
Belongs to the TUBGCP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: GMHA_AERS4
Sequence: MYQELIRNELTEAAGVLQAFLADEQNLKNIEAAAKLLADSFKQEGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYAGIAISDPSHLSCVSNDFGYDYVFSRYVEAVGRRGDVLLGISTSGNSGNILKAIEAAHAKGMKVIALTGKDGGKMAGLADVEIRVPHFGYADRIQEVHIKVIHILIQLVEKEMAK
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_MICAN
Sequence: MSKKNSQTSPQRQKMHVKKGDVVQVIAGSDKGKVGEILRALPQESTVVVKGVNIRTKHTKPQQEGESGQIVTYEAPIHSSKVMLYSEKKKIASRVGYTLTEDGRKVRILKKTGEIID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: THIG_PORPU
Sequence: MKPSFSLPHFVNDQLDQFKISDKSFSSRLMLGTGKYKNLQDAINSINVSGANIVTVAIRRAQNTKNLGRTNLIDGLDWSKLWILPNTAGCESAEEAVRIASLGQEIVKKLGQFDNNFIKLEVIPDSRYLLPDPIGTLKAAEYLINKGFVVMPYIGADPVLAKQLENIGCATVMPLASPIGSGKGLRNLLNLKIIIENAKIPVIIDAGIGTPSEAGKVMELGASAVLVNTAIARAKNSQTMARAMSLAVESGRLTYIAGRMPISEKAEPSSPILGISK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLYA_GEOSL
Sequence: MSILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRYYGGCHHVDVVENLAIERAKELFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLALEHKPKMIVVGASAYPRTIDFAAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCREEYAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRGFRLVSGGTDNHLMLVNLTGTELTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGTPAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRVNVLMKRFPLYAHRLS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_ECO8A
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PLSY_MYCPN
Sequence: MNAASAIALLIVFSLVIGYLMGSVMFADVFGKILNKDVRKLGSKNPGATNSIRVFGLKIGFLVGLCDALKGFLAFVFSFLIFSFWLQQYLNVNQYQKVYYLTYLSCFAATIGHIFPLYFKFKGGKAIATTGGSLLAISLWWFVICLVLWLLVTLITKYVSLASLVTFFILAIIILVPWLDYLYFFKPNPINAISYQNDWYIILFFVLWYWPLTIAVFWLHRKNIHRLLNKTENKVTQLN
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIAA_PARL1
Sequence: MSEPVGRAVLIAGPTASGKSGLALALAEKLGGEIVNADSMQLYREMRVLTARPSEEEEARVPHHLYGVTAASAPLSAGRWAVLAAEKMREIAARGRLPVVVGGTGLYFRALIEGLAPIPAIPDDVRAAVRAEVGDAGPHAHALLAEADPALAATIRPSDLQRIARGIEVARATGRPLSAWQQIPPEPLVSGTFAKIMLMPDRAWLQARCDRRFDLMLEEGALEEAAAMTALGLDPALPAAKALGLRPLMRHLAGEITLEEAAAAGKAETRAYAKRQETWLRTQMIAWKGFSTQHSESLNAEILSFIDDLGLTRS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: CRCB2_BACAN
Sequence: MIEALLVATGGFFGAITRFTISNWFKKRNKTSFPIATFLINITGAFLLGYIIGNGVTTGWQLLLGTGFMGAFTTFSTFKLESVQLLNRKNFSTFLLYLSATYIVGILFAFLGMKLGGI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYD_THEM4
Sequence: MYRTHNCGELRKKDVEKEVILSGWVDRIRDLGGIKFIILRDRYGKTQLVVNPNSPAYEISQELGREWVIQVYGKVLERPDETKTEMVTGEIEVEVNKIKVLSKSDVPPFYPGENVSEDLRLKYRYIDLRDERMQKNLIIRHKMAQAAREFLNKHDFLEVETPYLTKSTPEGARDFLVPSRLQKGKFYALPQSPQLFKQILMVSGFDRYYQFARCFRDEDLRADRQPEFTQIDIEMSFVKMDEILDLMESFARFVFGKVGIKLPEKFDRLSYEEAMELYGSDKPDRRYGMQLQDFTNYFVNTEFKVIKNVLERSGSVKGFITTIPISRKIASQFEEFVKQYGLGGLLWFKLDDEIVSPTAKFLKESYKKIVKEYNLDKGSVVLLAAHENREILNTALGALRLKVGKEYFNELEKVFDALWIVDFPFLEWNEEESRFEARHHPFTMPKNLEQKLEDIKAYAYDMILNGMEIGGGSIRIHDSEVQKRVFEIIGLTEEEANEKFGFFISALKYGVPPHGGIAFGFDRMVSIAANVASIRDVIAFPKTSSGICQLTGAPSTVEEKQLKELSIQIFKGGIENERNES
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIFH_TRISP
Sequence: MPIFTLNTNIKATDVPSDFLSSTSALVGNILSKPGSYVAVHINTDQQLSFGGSTKPAAFGTLMSIGGIEPSRNRDHSAKLFDHLNKKLGIPKNRMYIHFVNLNGDDVGWNGTTF
What is the function of this protein?
Tautomerization of the methyl ester of L-dopachrome.  Inhibits migration of human peripheral blood mononuclear cells.
What are the official names of this protein?
Macrophage migration inhibitory factor homolog, MIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase.
What is the protein family that this protein belongs to?
Belongs to the MIF family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by larvae into the host.
Protein: NFUA_ACTP2
Sequence: MEQQETIHISISEAAQTHFRRLLEQQEENTNIRIFVVNPGTPNAECGVSYCPPNAVEETDTQFEYNGFSAFVDEISLPFLDEAEIDYVTDPMGSQLTLKAPNAKMRKVADDAPFIERLDYVIQTQVNPQLASHGGRVTLIEVTEDKYAILQFGGGCNGCSMVDVTLKEGIEKQLLAMFPDELAGVKDVTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: Y1867_STAAM
Sequence: MVRESIPKEGENIKIQSYKHDGKIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDIILRRNVDILQQWIEQKKGPFAPDFIKVWKERYKKIRQY
What are the official names of this protein?
UPF0374 protein SAV1867.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: PHF6_BOVIN
Sequence: MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENQARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN
What is the function of this protein?
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
What are the official names of this protein?
PHD finger protein 6.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore. Note=Nuclear, it particularly localizes to the nucleolus.
Protein: TRPD_BORA1
Sequence: MTISATEALTRCIEHREIFHDEMLHLMRMLMRGEMSPQIASALLMGLRVKKETVGEITAAAQVMREFATPVVTPNPQDLLDMCGTGGDGSHTFNISTTAMFVAAAVGVPIAKHGNRSASSSSGSADVLEALGANLQLSPQAVAECIEATGIGFMFAPAHHGAMKNVAAVRKELGVRTIFNILGPLTNPAGAANQLMGVFHPDLVGIQVRVLERLGSRHVLVVHGKDGMDEASLGAATLVGELKNGVVREYEIHPEDYGLSMMSNRSIKVSNREQSRELVIEALDNVEGAARDIVALNAGLAIYAGNKADSIESALALAFEMIANGAARAKLEEFCAYTRKFAK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: MNMA_STRT1
Sequence: MTDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIDIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVVRDEDGIVHMLRGADNNKDQTYFLSQLSQEQLQKTMFPLGHLQKPEVREIAERAGLATAKKKDSTGICFIGEKNFKEFLSQYLPAQKGRMMTIDGRDMGEHNGLMYYTIGQRGGMGIGGQKGGDNAPWFVVGKDLSKNILYVGQGFHHESLMSTSLDASMIHFTRDMPEEFEMECTAKFRYRQPDSKVTVKVKGDKSEVIFAEPQRAITPGQAVVFYDGQECLGGGIIDQAYKDGKVCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_XANCP
Sequence: MSSYLFTSESVSEGHPDKIADQISDAVLDAILAQDKRARVACETMVKTGVAIVAGEVTTSAWIDLEALTRKVILDIGYNSSDVGFDGETCGVLNLIGKQSPDINQGVDRKNPEQQGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSALSWLRPDAKSQVTLRYEDGVATAIDAVVLSTHHDPGVKQKDLIEAVREEILKPVLPAKWLHKGTKFHINPTGKFVIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKIADELIEKLIRKHFDLRPFGIIQMLDLIHPMYQQTASYGHFGRKPKDFTYTDGTGAQHSATSFSWEKTDRAEALRAAAKLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_YERPN
Sequence: MSSKEQKTPNEQVSEEMENTAEQQVEATQETGECVDPRVAELEVQLSDALQRERESLLRAKAEVENIRRRTELDVEKAHKFALERFSSELLPVIDNLERALDTADKTNTELISMIEGVELTLKSLLDAVGKFGIEVVGETHVPFNPEVHQAMTMLESADHEPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.