PharMolix/UniProtQA huggingface dataset:
Protein: NUOB2_RHOPB
Sequence: MSYTLQRPGEDISVEEHMARTSLFARLEDLVAWSRKNSLWPFNFGLSCCYVEQVTALTSVYDQARFGAEVIRASPRQADLLVVSGTVFHKMAAPLLRLYEQMRAPRWVISMGACANSGGMYDIYSVVQGVDSFLPVDVYIPGCPPRPEAVLDALIMLQQQVGSEHRPLGVTVGNSAGLGFDAPRRRDQRRDERMAQTLLDPPEKL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MURG_CHLL3
Sequence: MNILFAGGGTGGHLYPAVAMAAMLKEMVPGVELSFAGTASGIEAGEVPRLGYRLHLIPVRGLKRGRSLSALLSNIGVLTDFAASLFRAAALIRRERPDVVVGTGGFVSAPVLLAAQLLGRKTLIQEQNAFPGLTTRLLSILAREVHVAFREATGYLMKKRGVFLTGNPARSFPQRDSSIGREAFGFDPLLPTLLVFGGSRGARAINNAVLRHLGRLTAGSNLIWQTGALDFGRIEKEVSPGRNLWIGAYIEDMGSAYAAADLVLCRAGASSIAELTNLRKPSVLVPYPHATGDHQRHNARALSGPGAALMIEDRELENPEAIEGVIALLHDRERLQMMGAEAGRLSAPEAARILAGRIIDLAEEH
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HSP1_SMIVI
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: Y1546_PYRCJ
Sequence: MEIVPVGEESLGVRSMCLYVETRDLRILLDAGVSLAPRRFGLPPHPLELQRAREVREQILRLAAYADVVTISHYHRDHFTVPYPSQYMATDSETYKAVYGEKTVLAKSPHDLNWSQRRRHYGLAKALDGVATVVYADGGEWRFGTTVVRASGPLWHGPAGSKTGRVIAFAVSDGEETLAFIPDVEGPVEEEAVHFAEEVKPTVVVVGGPPTYLGWDLASAVSNLKRIVDLRPRLLVLAHHLLRDVQWREKVGEVLQYAERRGVEVATYAKLAGREEQLLEARRRELYGETGRGEEAGEEEE
What are the official names of this protein?
UPF0282 protein Pcal_1546.
What is the protein family that this protein belongs to?
Belongs to the UPF0282 family.
Protein: PLSB_ECOHS
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METK_BIFAA
Sequence: MAELKLISAESVTEGHPDKVCDQISDAILDDMLAQDPHSHVAVETCATVGQFFVFGEVTSEGYSDIQNIVRSVVRNIGYTSSRVGLDADSCGVTVSLTEQSPEINQGVARLSGEEESKASREQRYEAQGAGDQGVMFGYACDETDVLMPLPIHLAHRLAYRLAEVRKSGEVPHLRPDGKTQVTIEYDDDDHPVRLDTVLVSTQHDPEVDQAWLKEQLTEHVIRPVLDDVLADRVAHDEYRVLVNPTGSFILGGPAADAGLTGRKIIVDTYGGAAHHGGGAFSGKDPSKVDRSAAYAARWVAKNIVAAGLAHKVEVQVAYAIGVADPVSINVETYGTEIGVTREQIQQAVRKVFDLRPAAIIDELDLKRPIYSKTAAYGHFGREDADFTWEATNKVDELKEAIKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_DESDA
Sequence: MSAKEIFFDVKAREKLSRGVDKLANAVKVTLGPKGRNVAIEKSFGAPVITKDGVTVAKEIELSDKFENMGAQLVKEVASKTSDAAGDGTTTATILAQAIYREGVKLVAAGRNPMAIKRGIDKAVEGLITELANLAKPTRDQKEIAQIGTISANSDTTIGNIIAEAMAKVGKEGVITVEEAKGLETTMDVVEGMRFDRGYLSPYFVTNPEKMVCEMDNPYILCTEKKISSMKDMLPVLEQVAKVNRPLMIIAEDVEGEALATLVVNKLRGALQVVAVKAPGFGDRRKAMLQDIAVLTGGQVASDDTGSKLENMTLAELGTAKRIVIDKENTTVVDGAGKSEDIKARVKQIRAQIEDSTSDYDREKLQERLAKLVGGVAVVHVGAATEVEMKEKKDRVEDALNATRAAVEEGIVPGGGTALIRVAKVLCDIKPADDDELAGVNIIRRAIEEPLRQIALNAGFEGSIVVEKVREGKDGFGFNAATGEYEDLIKAGVIDPKKVTRTALQNAASVASLLLTTECAIAEKPEPKKDAAMPDMGGMGGMGGMGGMY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_VARPS
Sequence: MATFKKFNKDKRPKRNTQSLLFKRKRFCRFTVAGVEEIDYKDIDTLRDFISENGKIIPARLTGTRAIYQRQLNTAIKRARFLAMVPYSDQHRV
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL16_HAMD5
Sequence: MLQPKQTKFRKMHKGRNRGLANGTDVIFGHFGLKASGRCRLTARQIESARRAMTRCIKRQGKIWIRVFPDKPITQKPLEVRMGKGKGNVEYWVDLIQPGKVLFEMGDVSEEIAREAFKLAAAKLPVGTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: TM182_XENTR
Sequence: MKLSIGIFFGGLFGALGILIYLVAFGSDYWLLAKEIEKCSENQETGDNATHSVLLHHEGFFWRCWFNHAEEENSNTMENFWFTNQAPTKNCTHAYLSPFPQNRDNSNSTSYHSALVYRGFWNIFMLLGVVTAVIGGFLIICAAPFTNHRIYKAGGGLFITSGILFALVVVMHVFWVQSVSDIKGYTDTRQQDCSQFTVYVSFGWSFMLAPFGIFFCLFAGMLFLLVGHTIHVHTK
What is the function of this protein?
May negatively regulate myogenesis and skeletal muscle regeneration.
What are the official names of this protein?
Transmembrane protein 182.
What is the protein family that this protein belongs to?
Belongs to the TMEM182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRG_PELUB
Sequence: MARYIFVTGGVVSSLGKGLSSASLAYLLQSRGYKVRIRKLDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFSGVSAKKSDNITTGKIYSDVLRKERKGEYLGKTVQVIPHITDRIKQFIKHDSSKEDFVICEIGGIVGDIESLPFVEAIRQFANDVGKKNALFIHLTLVPYLKASDEIKTKPTQHSVKELRSIGIQPDIIICRSERPIPLDHRKKISLFCNVDIKNVIETVDVRTIYEAPMSFFKEKLDLQVLNYFKLKSKKPANLNPWKKITKIILHNKKQVNIAIIGKYVELKDAYKSLDEALTHGGIDNKVKVNLVRIDSEKLKISEIKKKLKNISGILIPGGFGKRGTDGKIEAIKHARLNKIPFLGICYGMQMAIIEFARNQLNLKNATSSEFDKKGLPIIGLINEWTKDGKKIKGTDKDLGGTMRLGSYDAKLKDNSKISKIYKSKLIKERHRHRYEVNIAFKDKFEKKGMIFSGLSPDNKLPEIIELKNHPWFIGVQFHPEFKSRPLAPHPLFSSFIKAAKNHK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PSB28_PROMM
Sequence: MANANKTAAIQFTRGVDEPVVPDIKLTRSSDGRTGRALFVFDQPEIMAPETWAGITGMFMIDEEGELVTREVNARFVNGKPSALEVTYIWKSEADFERFMRFAKRYAACNGLGYSQN
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACCA_GEOMG
Sequence: MASQYQLEFEKPVFELEQKIQELADIAGDNVELKTEVVKLEKKVDKMREVIFANLSRWQMVQVARHIDRPFTLDYLTHIFTDFVELHGDRLFGDDHAIVGGMAKLDGEPVMVIGHQKGRDTKEKVYRNFGMPNPEGYRKALRLMEMAERFRMPIITFVDTPGAYPGIGAEERGQAEAIARNLREMAALTVPIIVVITGEGGSGGALAIAVGDRVLMLEYSIYAVISPEGCAAILWSDGTKGAQAAEALKLTAPDLKELDVIDEIVKEPLGGAHRDHETMAKNLHEALARHLKELKALSVEQLVEGRYQKFRKMSRFAE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_GLUDA
Sequence: MVYSRQKAGMSETGSSFSGAEPFTLAVDGMGGDGGPEVVVAGLAIAADRHPGARVLLIGDEATLRQELARHPKAAAICTIRPANSAIPMDMKPTAALRVRDSSMRLSMDAVAQGEAQGVVSAGNSGAMLALAKIVVKTLPGVSRPAMAAISPTLKGDVVMLDLGANVACDWRNLVEFAVMGEAFAKAVLGLPAPTIGLLNVGSEELKGDEKLRQAADVLRNSSLAAQFHGFVEGHDITAGTTDVVVTDGFTGNVALKTGEGALKMAFVLLRQVFRSGLLAKLGYLLVRPGLERMREWLDPRRYNGAVFVGLNGVVVKSHGGTDAEGFASAVDVAMDMVTHRFNESIREQLSRLDTLAAMRSGAEKEHPAVAAVS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DAPE_SALTI
Sequence: MSCPVIELTQQLIRRPSLSPDDVGCQALMIERLRKIGFTIEHMDFGDTQNFWAWRGRGETLAFAGHTDVVPAGDVDRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPHHRGRLAFLITSDEEASAKNGTVKVVEALMARNERLDYCLVGEPSSTEIVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDRGNDFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKERVHALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAIEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: YEHX_ECOLI
Sequence: MIEFSHVSKLFGAQKAVNDLNLNFQEGSFSVLIGTSGSGKSTTLKMINRLVEHDSGEIRFAGEEIRSLPVLELRRRMGYAIQSIGLFPHWSVAQNIATVPQLQKWSRARIDDRIDELMALLGLESNLRERYPHQLSGGQQQRVGVARALAADPQVLLMDEPFGALDPVTRGALQQEMTRIHRLLGRTIVLVTHDIDEALRLAEHLVLMDHGEVVQQGNPLTMLTRPANDFVRQFFGRSELGVRLLSLRSVADYVRREERADGEALAEEMTLRDALSLFVARGCEVLPVVNMQGQPCGTLHFQDLLVEA
What is the function of this protein?
Part of an ABC transporter complex involved in low-affinity glycine betaine uptake.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Glycine betaine uptake system ATP-binding protein YehX.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: HRH1_PONPY
Sequence: MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFRQQISVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVQKHCQHRELINGSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDGEVDKLHCFPLDIVQMQTVAEGSSRDYVAINQSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
What is the function of this protein?
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
What are the official names of this protein?
Histamine H1 receptor, H1R, HH1R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LG3BP_MESAU
Sequence: MAFLWLFSLWLLVPGTQGTKDGDMRLVNGASANEGRVEIFYRGQWGTVCDNLWNILDANVVCRALGYENATQALGRAAFGPGRGPVMLDEVECTGTEPSLANCSSLGWLKSRCGHEKDAGVVCSNETGGVHILDLSGDLPNALGQIFDSQQGCDLFIQVTGQGHGDLTICAHKLILNTNPEAQALWQVVGSSVIMRVDAECMPVVRDFLRYFYSRRIEVTMSSVKCLHKLASAYGATQLQDYCGRLFATLLPQDPTFRTPLELYAYAQATRDSVLEDLCVQFLAWNFEPLTQAEAWLSVPTALLQALLSKSDLAVSSELDLLKAVDQWSMESSASHAEVERLLEQVRFPMVLPQELFELQFNLSLYEGHRELFQRKTMEALEFHTVPFRVLAKYRGLNLTEDTYQPRLYTSSTWSTLVTESSSRSRAAVQVYGYAQYYPYGYDSRRWYYPYQSFQTPQHPSFLFVDKLISWSATYLPTVQSCWNYGFSCTPEELPVLGLTKSSYSEPAIGYENKALMLCGGYSVVDVANFAGSKAPIPSALDTNSSKISSLFPCSSGAFSGFRVVIRPFYLTNSTDLD
What is the function of this protein?
Promotes integrin-mediated cell adhesion.  May stimulate host defense against viruses and tumor cells (By similarity).
What are the official names of this protein?
Galectin-3-binding protein, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Pancreas cancer-associated protein 4.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix.
Protein: GLHA_EQUAS
Sequence: MDYYRKHAAVILATLSVFLHILHSFPDGEFTTQDCPECKLKKNKYFSKLGVPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFIRVTLMGNIRLENHTQCYCSTCYHHKI
What is the function of this protein?
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH.  These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
What are the official names of this protein?
Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Follicle-stimulating hormone alpha chain, FSH-alpha, Follitropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Thyrotropin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit alpha family.
What are the subcellular locations of this protein?
Secreted.
Protein: EWS_HUMAN
Sequence: MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMDKGEHRQERRDRPY
What is the function of this protein?
Might normally function as a transcriptional repressor.  EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process.  They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex.  They may also contribute to an aberrant activation of the fusion protein target genes.
What are the official names of this protein?
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein.
What is the protein family that this protein belongs to?
Belongs to the RRM TET family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Protein: Y8505_DICDI
Sequence: MITPIGKNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0283527.
Protein: FDHE_HAEI8
Sequence: MSIKILSESEIKQVANSYQAPAVLFANPKNLYQRRAKRLRDLAQNHPLSDYLLFAADIVESQLSTLEKNPLPPQQLEQLNAIEPLNAKTFKRDSIWREYLTEILDEIKPKANEQIAATIEFLEKASSAELEEMANKLLAQEFNLVSSDKAVFIWAALSLYWLQAAQQIPHNSQVENAENLHHCPVCGSLPVASIVQIGTSQGLRYLHCNLCESEWNLVRAQCTNCNSHDKLEMWSLNEELALVRAETCGSCESYLKMMFQEKDPYVEPVADDLASIFLDIEMEEKGFARSGLNPFIFPAEDA
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITB6_RAT
Sequence: MGIELVCLFLLLLGRNDHVQGGCAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPENLLAKGCQLPFIENPVSQVEILQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCSNGILFPHQKKCSHMKVGDTASFNVSVSITNCEKRSRKLIIKPVGLGDTLEILVSAECDCDCQREVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSRRSCIECYLSADGQAQEECEDKCKATGATISEEEFSKDTSVPCSLQGENECLITFLITADNEGKTIIHNISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKVGLSSDG
What is the function of this protein?
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity).  It recognizes the sequence R-G-D in its ligands (By similarity).  ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).  Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
What are the official names of this protein?
Integrin beta-6.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
Protein: REP12_ECOLX
Sequence: MDKSSGELVTLTPNNNNTVQPVALMRLGVFVPTLKSLKNSKKNTLSRTDATEELTRLSLARAEGFDKVEITGPRLDMDNDFKTWVGIIHSFARHNVIGDKVELPFVEFAKLCGIPSSQSSRRLRERISPSLKRIAGTVISFSRTDEKHTREYITHLVQSAYYDTERDIVQLQADPRLFELYQFDRKVLLQLKAINALKRRESAQALYTFIESLPRDPAPISLARLRARLNLKSPVFSQNQTVRRAMEQLREIGYLDYTEIQRGRTKFFCIHYRRPRLKAPNDESKENPLQPSPAEKVSPEMAEKLALLEKLGITLDDLEKLFKSR
What is the function of this protein?
This protein is essential for plasmid replication; it is involved in copy control functions.  In vitro, binds to the DNA repeat units, BCDD'D'', EFG and HIJ (By similarity).
What are the official names of this protein?
RepFIB replication protein A.
What is the protein family that this protein belongs to?
Belongs to the initiator RepB protein family.
Protein: PHS_AERHH
Sequence: MSELASQQCEACRADAPKVSEQELNELMRLIPDWQPLVVKGELQLRREFTFRNFKEALAFTNRLGELAEAEFHHPAILTEWGKVTVSWWTHKIGGLHRNDFIMAARTDELLK
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: TRUA_LATSS
Sequence: MTQRYRVTVAYDGTDFAGFQVQPKQRTVQGTLEKALTKMSKGAYIQVYGSGRTDSGVHAMGQVVHFDYPSELPAKSMLRALNSLLPLDMEVVDSQLADDDFHARFSTVGKRYMYRVDLGHYTNPFKRRYTGHYPYPIDVERIKAALSDVMGTHDYTSFAAAGGVIKDKVRTIYEATVVYNEAENELIFEFHGNGFLYNMVRILVATLLEIGNGRRDVHDFLRLYEVKDRQQARSTAPASGLYLKEVYYK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GLMU_BRASO
Sequence: MTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGHDAVEKEAKRLCPDVAIFVQRERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFARLRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREHADASEAERAITLCNAGVMAMDGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAEAAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFSHVVQSKLGSNTLLGPFARLRPGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVGAHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPINIGARAYIGSGSVITRDVPDDALALERSPQTTKEGAAARFRNAKLRQTK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLA3_LACAI
Sequence: MDSLHSTMNQHVKGKHLSFEERVIIQLRLKDGYSLRAIARELNCSPSTISYEVKRGTVKLYHGKVKKYKATQGHDAYKAHRKNCGRKSDFLRKAQFMRYVHKHFFKDGWSLDVCSNRATAVGEF
What are the official names of this protein?
Uncharacterized 14.4 kDa protein in laf 3'region.