PharMolix/UniProtQA huggingface dataset:
Protein: BRE1_KLULA
Sequence: MNDHFVKRPKLELSDPSEPLTQKDVIAFQKEALFRCLNKWRVKANQLVEENEVLAAGLSKTTESVSGCCSSIVVLARSVVEDCSDEQDKRFLQQLINTEDEHTLTQIISNNSARICELILKTSGSNISDNIGRLQELESLTLTLQKLLKSSENKLKKATEYYENIIAQYDRQDSESVSRVFNTADDDSNVKKEKQSSTGASSVNDESNDNSDKSQSNKESAVSQAHHEIEINDLNTQISVLEATVKELTEWKNQNERELSELRQTVASNKSALSNNQLQSNSQHQPDASVTNEKISSLTKQNEQLQQINEGYLTKFQQLSADREIFNNKLTSEFNLAQETLKKHNASLEKDLVRIRTIRDELLAKVSLLEAQKTKSEMLEDLEKSLNIQQEQLQKFESRSSENASQDALMKELQDLEKAFREVSHLSNKKYAAYLNQESVLSKLTVEKTKASEKYFAAMRSKDAIMIENKNLSKNLNKSNELIVQLKDLEKTLQQKIVNVHMQLSLSQENEKRVKESNKETSMKIVELTSENNKLKKSTERLESETRNLIGTKTELESKIKDKDIENKQLKIKVSSAEAKSKKLYKTLLSNGGDNGALAEELENFRTIIYCSLCSKNWKNTALKTCGHVFCDVCCKERLAARMRKCPTCNKPFSSNDLLSIHL
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1, RING-type E3 ubiquitin transferase BRE1.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURI_CUPPJ
Sequence: MPNVNPAPIGVFDSGLGGLSVLREIRALLPHESLLYLADSKYAPYGEKPEAFVQARTLQACEWLLAQGCKALVIACNTATGHAVELLRQTLPVPIIGVEPGLKPAAAASQSKVVGVLATANTLKSGKFARLLASLDGESRFICEAGLGLVPLIEQGDIDGPDIRGRLDNYLTPMLEAGADTLVLGCTHYPFLSDTIRDMVGNQLTLVDTGSAIARQLARKLVEHDLAVAPGAVPQDRFVSTKDAAHLRQMAAALLHIETQAETVAIEPAPAF
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: PA2IA_ODOIS
Sequence: MFTLKKSLLLLFFLGTISLSLCEQERSAEDEGEVIEEEVKRGFMDTAKNVAKNVAVTLLDKLKCKITGGC
What is the function of this protein?
Has antimicrobial activity against Gram-negative bacterium E. coli ATCC 8739 (MIC=100 ug), against Gram positive bacteria S. aureus ATCC 6538 (MIC=25 ug), methicillin-resistant S. aureus ATCC 43300 (MIC=100 ug), B. subtilis ATCC 6633 (MIC=12. 5 ug) and against fungus C. albicans ATCC 90028 (MIC=100 ug).
What are the official names of this protein?
Palustrin-2ISa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1795_LACLN
Sequence: MKNNSVKIVVATGIGAALFVIIGWLINIPTPIPNTSIQLQYAVLALFSALFGPLAGFLIGFIGHALKDSFLYGAPWWTWVLGSGLMGLFLGFGVKRESLTQGIFGNKEIIRFNIVQFLANVVVWGLIAPIGDILVYSEPANKVFTQGVVAGLVNALTIAVAGTLLLKLYAATRTKSGTLDKE
What are the official names of this protein?
UPF0397 protein LLNZ_01795, ORF6.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIGI_SPHSK
Sequence: MTNDERILSWNETPSKPRYTPPPGAIDAHCHVFGPMAQFPFSPKAKYLPRDAGPDMLFALRDHLGFARNVIVQASCHGTDNAATLDAIARAQGKARGIAVVDPAIDEAELAALHEGGMRGIRFNFLKRLVDDAPKDKFLEVAGRLPAGWHVVIYFEADILEELRPFMDAIPVPIVIDHMGRPDVRQGPDGADMKAFRRLLDSREDIWFKATCPDRLDPAGPPWDDFARSVAPLVADYADRVIWGTDWPHPNMQDAIPDDGLVVDMIPRIAPTPELQHKMLVTNPMRLYWSEEM
What is the function of this protein?
Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway (PubMed:9864312).  Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA) (PubMed:29658701, PubMed:22475079).  The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions (PubMed:22475079).  Also catalyzes the reverse reaction (PubMed:22475079, PubMed:9864312).  Is essential for the growth of Sphingobium sp.  SYK-6 on vanillate but is not responsible for the growth of this strain on syringate (PubMed:9864312).
What are the official names of this protein?
2-pyrone-4,6-dicarboxylate hydrolase, PDC hydrolase, 2-pyrone-4,6-dicarboxylate lactonase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. PDC hydrolase family.
Protein: B3GT5_ARATH
Sequence: MKHNNKVSKRLTMTWVPLLCISCFFLGAIFTSKLRSASSDSGSQLILQHRRDQELKIVTQDYAHEKKKSQDNDVMEEVLKTHKAIESLDKSVSMLQKQLSATHSPQQIVNVSATNSSTEGNQKNKVFMVIGINTAFSSRKRRDSLRETWMPQGEKLEKLEKEKGIVVKFMIGHSSTPNSMLDKEIDSEDAQYNDFFRLDHVEGYYNLSAKTKSFFSSAVAKWDAEFYVKIDDDVHVNLGTLASTLASHRSKPRVYIGCMKSGPVLTKKTAKYREPEFWKFGEEGNKYFRHATGQIYAISKDLATYISNNQPILHKYANEDVTLGSWFIGLEVEQIDDRNFCCGTPPDCEMRAEAGEMCVATFDWKCSGVCRSVDRMWMVHVMCGEGSKAVWDANLKLS
What is the function of this protein?
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue.
What are the official names of this protein?
Probable beta-1,3-galactosyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: FTHC_YEAST
Sequence: MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ
What is the function of this protein?
Only enzyme known to utilize 5-formyltetrahydrofolate (folinic acid) as substrate.  Contributes to tetrahydrofolate metabolism in an alternative way of folate biosynthesis.  May regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
What are the official names of this protein?
5-formyltetrahydrofolate cyclo-ligase, 5,10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase.
What is the protein family that this protein belongs to?
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TUSB_ECOLI
Sequence: MLHTLHRSPWLTDFAALLRLLSEGDELLLLQDGVTAAVDGNRYLESLRNAPIKVYALNEDLIARGLTGQISNDIILIDYTDFVRLTVKHPSQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL7_PIG
Sequence: MFHVSFRYIFGIPPLILVLLPVASSDCDIEGKDGGVYQNVLMVSIDDLDRMIDFDSNCLNNEPNFLKKHSCDDNKEASFLYRAARKLKQFIKMNISEEFNHHLSTVSQGTLTLFNCTSKVKGRKPPSLGEAQLTKNLEENKSLKEQKRQGDLCFLKILLQKIKTCWNKILRGAKEY
What is the function of this protein?
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors.  It is important for proliferation during certain stages of B-cell maturation.
What are the official names of this protein?
Interleukin-7, IL-7.
What is the protein family that this protein belongs to?
Belongs to the IL-7/IL-9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_LEPBJ
Sequence: MNSSSIQRKILVTSALPYANGPIHLGHVLEGIQTDIWVRFQKAIGNECYFFCADDTHGTPVMLAARKEKITPEQLIERVGQEHYTDLTSFGINYDNYDSTHSKANQEISKDIYLKLKEKGHISKRSIEQAYCEKDRMFLPDRFIKGTCPNCNSKNQYGDNCEVCGATYNPKDLIDSHCTLCGTPPVVKNSDHIFFKLGNFHKKTEQSNVDFDLQSWIETSEAVSESEGVKKKLKEWFDAGLQDWDISRDGPYFGFEIPSEKNKYFYVWLDAPVGYMASSKNFFEKNFPNEPNKFDSFWKDKNSEIVHFIGKDILYFHTLFWPAMLEGSGYRSPSKIHVHGFIGVNGEKMSKSRGTFIKAKTFAKFLDAEHLRFYLAAKLGPGMDDIDLSFDDFVNKVNADLVGNLINSVSRVSTTILDTLDRTLGTVSEEGLALLEEILTQPVKTGTRDDSIQNIIKTAYEQRNYAKVMREITRLGDRVNRYVNDNAPWKLIKENPEKAREIVTAVLNASRFLAIYLYPVVPKISEQIYKLLNLKGSPEFKDLDKSRILEKTKINPYEMITKRVDEKAIKVMLEENKQSEHPKKEEIPKSSNKEEGIEISIEELSKVELRVGEIVEAKPVEGADKLVNVKVDLGELGIKNVFAGIKIAYQPENLKGLKVVVVANLKPRKMKFGISEAMLLASGEGESLSLFVPHKDAKPGDRLK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SALNS
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFDGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWRQVELNPFFCPDADKLDALDELMRALKKEGDSIGAKVTVMASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGEGFNVVALRGSQNRDEITAQGFQSNHAGGILGGISSGQHIVAHMALKPTSSITVPGRTINRAGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQNADVKTEIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: DBH_RICCN
Sequence: MNKTEFIAFMTDHGHNHKHASHKTLTKAEAEKALNLVLDSVISAIKSHHNINITGFGSFEIHHRKAREGRNPKTGAKMKIDAYNQPTFRAGRKMKEACN
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: EAT1_ORYSJ
Sequence: MIVGAGYFEDSHDQSLMAGSLIHDSNQAPASSENTSIDLQKFKVHPYSTEALSNTANLAEAARAINHLQHQLEIDLEQEVPPVETANWDPAICTIPDHIINHQFSEDPQNILVEQQIQQYDSALYPNGVYTPAPDLLNLMQCTMAPAFPATTSVFGDTTLNGTNYLDLNGELTGVAAVPDSGSGLMFASDSALQLGYHGTQSHLIKDICHSLPQNYGLFPSEDERDVIIGVGSGDLFQEIDDRQFDSVLECRRGKGEFGKGKGKANFATERERREQLNVKFRTLRMLFPNPTKNDRASIVGDAIEYIDELNRTVKELKILVEQKRHGNNRRKVLKLDQEAAADGESSSMRPVRDDQDNQLHGAIRSSWVQRRSKECHVDVRIVDDEVNIKLTEKKKANSLLHAAKVLDEFQLELIHVVGGIIGDHHIFMFNTKVSEGSAVYACAVAKKLLQAVDVQHQALDIFN
What is the function of this protein?
Transcription factor involved in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development (PubMed:23519457, PubMed:23385589).  Interacts with TDR and promote tapetal PCD by regulating the expression of RTS, and the two lipid-transfer proteins C4 and C6, which function in microspore development (PubMed:23519457).  Acts downstream from and interacts with TDR in the regulation of tapetal PCD.  Regulates directly the aspartic protease AP25 and AP37 during tapetal PCD (PubMed:23385589).  May not target the cysteine protease CP1 (PubMed:23519457, PubMed:23385589).
What are the official names of this protein?
Transcription factor EAT1, Basic helix-loop-helix protein 141, OsbHLH141, Protein DELAYED TAPETUM DEGENERATION, Protein ETERNAL TAPETUM 1.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
Protein: NUG2_ARATH
Sequence: MVKKEKKANVSGKPKHSLDANRADGKKKTTETRSKSTVNRLKMYKTRPKRNAGGKILSNEYQSKELPNSRIAPDRRWFGNTRVVNQKELEYFREELQTKMSSNYNVILKERKLPMSLLTDNKKQSRVHLLDMEPFQDAFGRKTKRKRPKLVASDYEALVKKAAESQDAFEEKNGAGPSGEGGEEEDGFRDLVRHTMFEKGQSKRIWGELYKVIDSSDVIVQVIDARDPQGTRCHHLEKTLKEHHKHKHMILLLNKCDLVPAWATKGWLRVLSKEYPTLAFHASVNKSFGKGSLLSVLRQFARLKSDKQAISVGFVGYPNVGKSSVINTLRTKNVCKVAPIPGETKVWQYITLTKRIFLIDCPGVVYQSRDTETDIVLKGVVRVTNLEDASEHIGEVLRRVKKEHLQRAYKIKDWEDDHDFLLQLCKSSGKLLKGGEPDLMTGAKMILHDWQRGRIPFFVPPPKLDNVASESEVIVPGIDKEAIADNSQAAAALKAIAGIMSTQQQKDVPVQRDFYDEKDLKDDKKAKESTETDAENGTDAEEDEDAVSEDGVESDSDADEDAVSENDEEDESDSAE
What is the function of this protein?
GTPase involved in pre-60S ribosomal subunit maturation.
What are the official names of this protein?
Nuclear/nucleolar GTPase 2, AtNug2, DAR GTPase 5.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus.
Protein: TILS_LEGPA
Sequence: MTRPLLSPEWVARLKQFKKLIVGFSGGLDSTVLLHVLASTPPLSNQLLAVHINHGISGNSLNWQRHCEQLCLDLGIAFIAKAIEFDRSANVEEAARNARYDFFSSLLEDNDCLVLGHHLDDQAETVLLQLFRGAGVDGLAAMQECSNLGAGQLARPFLTCPRVELEHYARIHELKWIEDESNQDTKYSRNYLRHRVMPLLLEKWPGVAGNISRAATHCQQAKANLEVLAIKDCPDLLNATDHLLIEPIKGLEFERITNVLKFWLKKNRIQLPSSKTFHRIIHEIIFAKLDAMPTVSWNQIQVRRFQQHLYLLKADQINLPKAIKWQQFPASLTYPDADIKLSAVKAQKGLMIPKDAQIEIRFRKGGEEIYWHGQTKHLKKLFQEWQIPPWVRDRVPLVYINDQLACVVGYAVSDLFFTTNPLEAWSIVNNS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENDON_BPT5
Sequence: MATNTKYKRDAISIMRDGIKSRYSKDGCCAICGSSEDLELHHYHTISQLIKKFAKELQLDFTDENIVLSNREAFYKKYEHELVRDVVTLCQHHHQLLHKVYTKEPPLFSANKQKAWVQKQKDKIQNPQEKTQVKTETKSGFARFL
What is the function of this protein?
Endonuclease responsible for the single-chain interruptions (nicks) located at specific positions in the minus strand of the viral genome.
What are the official names of this protein?
Nicking endonuclease.
Protein: TADA_STRP8
Sequence: MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKNS
What is the function of this protein?
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
What are the official names of this protein?
tRNA-specific adenosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: TXM3A_DINQU
Sequence: MKLSALSIIFGMILVMTIMYTKAEAEAEAEADADADAKAEAEAFWGTLAKWALKAIPAAMGMKQNK
What is the function of this protein?
May have antimicrobial properties, like most ant linear peptides (Probable).  In addition, when tested in vitro on the parasite Trypanosoma cruzi (responsible of the Chagas disease), shows only a weak reduction of the number of the trypomastigote forms.  Has no activity on the epimastigote forms.  Its activity on the amastigote form has not been tested (PubMed:28976889).
What are the official names of this protein?
M-poneratoxin-Dq3a, M-PONTX-Dq3a, Dinoponeratoxin, DnTx, Peptide sDq-2561, U-poneritoxin(01)-Dq6a, PONTX(01)-Dq6, U-PONTX(01)-Dq6a.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family. Ponericin-W subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YUC6_ARATH
Sequence: MDFCWKREMEGKLAHDHRGMTSPRRICVVTGPVIVGAGPSGLATAACLKERGITSVLLERSNCIASLWQLKTYDRLHLHLPKQFCELPIIPFPGDFPTYPTKQQFIEYLEDYARRFDIKPEFNQTVESAAFDENLGMWRVTSVGEEGTTEYVCRWLVAATGENAEPVVPRFEGMDKFAAAGVVKHTCHYKTGGDFAGKRVLVVGCGNSGMEVCLDLCNFGAQPSLVVRDAVHVLPREMLGTSTFGLSMFLLKWLPIRLVDRFLLVVSRFILGDTTLLGLNRPRLGPLELKNISGKTPVLDVGTLAKIKTGDIKVCSGIRRLKRHEVEFDNGKTERFDAIILATGYKSNVPSWLKENKMFSKKDGFPIQEFPEGWRGECGLYAVGFTKRGISGASMDAKRIAEDIHKCWKQDEQVKKI
What is the function of this protein?
Involved in auxin biosynthesis via the indole-3-pyruvic acid (IPA) pathway.  Also able to convert in vitro phenyl pyruvate (PPA) to phenyl acetic acid (PAA).  Required for the formation of floral organs and vascular tissues.  Belongs to the set of redundant YUCCA genes probably responsible for auxin biosynthesis in shoots.
What are the official names of this protein?
Indole-3-pyruvate monooxygenase YUCCA6, Flavin-containing monooxygenase YUCCA6, Protein HYPERTALL1.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1474_HAEIN
Sequence: MLIVQNLQTNILKSISFSIEKSECLSVVGESGSGKTTLLNAIAGYIDYSGSILWNNQVLENNPPWKRNFRYLNQRLYLFPHKTVRGNLILANPSASDAEQQILLSELKIDHLINRYPHQLSGGEQQRVALARALIYRPDLLLLDEPFSSLDWSSRKDIWKVLKNLIQTNEITTILVTHEPKEAEYFSGKQIQLYQGQLI
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein HI_1474.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: IF2P_METAC
Sequence: MREVLYMTDKKNLRTPIVCVMGHVDHGKTTLLDKIRGTAIVSGEAGAITQHIGATEVPIDVIVNKLGDPKLRDRFMVPGLLFIDTPGHHAFTTLRSRGGALADLAIVVVDINEGFKPQTYESLQILKRFKTPFVVVANKIDRIGGWASQKDMPFAATFKKQSPDVQGRLETKLYEVIGELYNQGFAAERYDRVTNFQKTLGVVPASAVTGEGIPDVLMVLLGLAQKFLEANLQYSAKNPGVGTVLEVKEEKGLGATLDVILYDGTLKKGDTVVIGSLGEPIQTKVRALLKPRELSEIRYESKFKQVSEVTAAAGVKISAPGLDGALAGSPIRVATEETLGEIVAQVKSEIDEVRIDTGSVGVMIKADTLGSLEALVHEFQKDEVPIRKAEVGDISHRDAVEASTVEDPLYSVLIGFNVKVHPDARDFLQESTVKVFTSDVIYRLVEDYQKYVKEQQELAEKKIFETIIRPGKFKILPGCVFRQSKPAVVGVRVLGGVVRTNADVMLENGNVVGKIKGLQSEGENIPSAKVGKEVAMAIEGATVGRQIKEEDVLYINVPERHAKVLEHEIYDSLSTDEKETLDIFLTLKRKNNPFWAK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: TYSY_LACPL
Sequence: MLEDSYLQLARTILEHGTYKDDRTGTGTYSVFGYQMRFDLSQGFPLLTTKKVPFGLIKSELLWFLHGDTNIQYLLQHHNHIWDEWAFKNWVTSADYDGPDMTNFEHRRLDDPDFAPIYQAQMQTFDDQILTDDAFAAKYGNLGDVYGAQWRHWQTRQGKTIDQIANVIEMIKTHPDSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDVFLGVPFNIASYALLTHLIAKETGLAVGEFVHTLGDAHIYTNHVEQVKTQLTRQPRPAPQLTLSGAHDSIFDYQMSDIKLSGYDPAPAIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCC_EDWTA
Sequence: MSSTDSVVAGQAKVSTWRKTDTRWVLGLFGTAIGAGVLFFPISAGIGGLLPIIFMLILAFPIAFFCHRALARLCLSGRSISDNITDTVDQHFGHVGGVVITFLYFFAICPLLWIYGVTITNTFIAFWQHQLLLPAINRGVVALAILLVMAFFIYFGKDLMVKVMGYLVFPFITCLVLISLSLIPYWTSDIFTSFDMHSLSLFGSHGILVTVWLGIAIMVFSFNFSPIVSSFVVSKREEYEADFGREYTEQKCAKIISRASVLMVVVVMFFAFSCLFTLSPQDMAQAKQQNIPILSYLANHFSSLGSGKSTYATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLIIKFGYHGEKSQAPMKKLNMISMVIIMGSTWVIAYINPNILDLIGAMGAPIIAALLCLLPMYAVWRVPALAKYKGKASNYFVTIIGLLTILNIVYQLM
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGC_IDILO
Sequence: MQYTAAQSQSVAIIGASGYVGVELTRLVQQHPALSLLGCYVSEHSSDAGSLLSDLHPQYAHLVKLSLQGLSSQKKELIKSSADTVFLCTDHGVSVELAPEFLAAGLKVIDLSGGFRLNATEDYPSFYGFEHQQDSWLQQAVYGLAEWYPQEIAAAQLVAVPGCYPTAALMALLPVKQAGLLSCNKIIINAVSGVTGAGRKAALTSHGAELSLQAYGLFEHRHTPEIAQQLQHEVLFTPHLAQFPRGILATVYAELNDDVSDADLDKAYQCYADQPLVRFEKQARPAIKNVVQQPFVDIGWHRQGNQLIAFSAIDNLLKGAASQAIQCVNLQLGLALEEGLL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_PLAFA
Sequence: MGIKGLTKFIADAAPNAIKEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANATSNQNKNKNNSKRGYILTEINLEQVLKGLNLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEPQIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLIVEETKKEQTLPARKGKKRPTAGDKNKQKAVKRKIEQANANGHHKMKEENKSVDNEKNEDGIKSVDNEKNEDGIKSVDDEKNLDDEKNLDDEKNKDDEKKSLDNFSSNLFDSDKESESGNIIKNEKQNMDDEKINDNLPSLFGDHSRIRHTENKDNISDINNNNNNNNNNSSSNNNNISNNHFNSVSSNSTFNSSTKLKSEDTLKSNSPLKEDSPNSYNNIKNNNHTININSQINNHKEPISNNNLNNINNSTEIKKKNTLFLLPFCPKDVTNVKKKKYTQRC
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RRF_YERPN
Sequence: MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVEDSRTLALTVFDRSLSAAVEKAIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAEAEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKKVDAALAVKEAELMDF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_DEHMC
Sequence: MPKMKTRKTAAKRFHVTGTGKIMRSKGMKSHLRRNKSARVLRQFDEMSQVAGVDRARIQKLIPYGVS
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.