PharMolix/UniProtQA huggingface dataset:
Protein: YU82_HATHI
Sequence: MSGHSKWHNIQAKKSKVDAKRGKIFTKIGKEIAIAAKNGGPNPDANPKLRDVIAKAKANNMPKDSIERAIKKAAGELAGVNYEEILYEGYGPDGIAVLVQALTDNKNRSAGNVRHAFSKHGGNLGSTGCVSFMFQTKGQIVIEKNDELDEEELMMMALECGAEDFQSEDEVYIITTSPEDFGSVRETLEEKGLEFLEAEVKSIPDTYTVIDENTAGKFQKMLDVLEDDEDVQDVYHNAEFPEGWEE
What are the official names of this protein?
Probable transcriptional regulatory protein ORF2U.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_CAMJR
Sequence: MIQSFTRLAVADNSGAKELMCIKVLGGSKRRYATVGDVIVASVKKALPNGKVKKGQVVKAVIVRTKKEIHRDNGSLIRFDENAAVILDNKREPIGTRIFGPVGREVRYGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: GPMA_XYLF2
Sequence: MTRKLVLLRHGQSQWNSMNRFTGWVDIGLTEQGHQEATMAGHLMKKEGLEFDVAHTSLLKRAIHTLQDALKALDQDWLPIYKSWRLNERHYGALQGLDKIDTAAKHGEEQVNIWRRSYDIQPPPIDLDDPSHPMRDRRYAALDRKVLPVRESLKNTLERVLPYWNDAIAPQLNDNKTVLISAHGNSLRALYKYLNKESDEKILNVNIPTGIPLLFELSDTLQVVSYRYLGDPDAAQRAAEMVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: SYL_SALTO
Sequence: MTEAAAPASDIPPFRYTADLADEIERRWQDTWEREGTFHAPNPTGPLADPEHPRAGAEKLYVLDMFPYPSGAGLHVGHPLGYIGTDCFARYQRMAGRNVLHAMGFDAFGLPAEQYAVQTGTHPRTTTEANIARYKAQLRRLGLAHDERRSVATIDADFYRWTQWVFLQIYNAWYDSSAKRARPIAELVAEFSGGSRRTPDGRPWGELTDAERRAVVDQHRLAYVSQAPVNWCPGLGTVLANEEVTADGRSERGNFPVFKRNLKQWMMRITAYGDRLLDDLEKLDWPEPIKLMQRNWIGRSTGAHIEFPTSAPDSDAEGEPRISVFTTRPDTIFGATYLVLAPEHDLVDTLVPTAWPAGVPQAWTGGQASPREAVAGYRKVAAAKTDLERQAETKEKTGVFIGSYATNPVTGAQIPIFIADYVLAGYGTGAIMAVPGQDERDWAFAEVFDLPIVRTVQPAEGFAGKAYTGDGLAINSATPERGLDLNGLGVAEAKARTIAWLEAGGHGSGAVTYRLRDWLFSRQRYWGEPFPIVYDETGAAIALPEELLPVELPEVDDFAPRTFDPSDAESNPETPLSRRRDWVEVELDLGDGPKRYTRETNVMPQWAGSCWYELRYLDPTNGDRFVDPEAERYWMGPRGEGDCGGTDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSFEPFRKLFNQGYIQAYAYTDARGAYVPAEEVVERSGTYYLGDVQVNREYGKMGKSLRNVVTPDEMCAAYGADTFRVYEMSMGPLEVSRPWETRAVVGSFRFLQRVWRAIVDERSGASRVVDVPADEATRRLLHRIVDGVRGDMEAMRFNTTIAKLIELTNALTRLPETPREVAEPLVLMLAPFAPHVAEELWRRMGHETSLTYADFPVADPALLVAESVTYPVQVNGKVRGRIEVPADAGQETVRAAALEAVAASLAGKEPRKVIVVPGRMVSVVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_LEPIC
Sequence: MISPAKINLGLEIPFKRLDGFHEIRSVFLKISWGDDIEIEPASNGVFELFSNNEIILEKRKLYDQVSERGDIKNNILYKTFIKARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFSWCPFFTSDEMFVLAAEIGSDVPFFLGEGHAFVTGKGEILEEIEVHHGQGILALTPQVMNTSEMYSLLKKPLQESASQKNGNTLSKNLISILKNGDWSSLQGRLWNDFEPVAFQLHPELGVLKDKFLEFGSSYCSLTGSGSSMYGLVQGLEIQEELLQRLRQEFSNLTFVRFNF
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MATK_ROSRU
Sequence: MEEFQGYLELYRSQQHDFLYPLIFREYIYALAHDRGLNRSVLLDNVGYDKKSSLLIIKRLISRMYQQNHFLISVNDSNQNKFFGYNKNLYSQIISEGFAVIVEIPFSLRLVSSLKETETVKSYNLRSIHSIFPFFEDKFPHLNYASDVLIPYPIHLEILVQTLRYCVKDPSSLHLLRLFLHEYYNWNTLITPKKSIFAKSNQRLFLLLYNSYVCEYESILLFLRNQSNHLRLTSFGILFERIRFYEKIKYPVEEVFANDFPATLWFFKDPFIQYVRYQGKSILASKDTPLLMNKWKYYLVHFWQCHFYVWFQPGRIHINQLSKHSFDFLGYLSSIRPNISVVRSQLLENSFLMDNAMKKLDTLFPIIPMIGSLAKVKFCNTSGHPISKSSWADSSDSDIIDRFVRIGGNLSHYYSGSSKKKSLYRIKYILRLSCVKTLARKHKSTVRTFLKRLGPKLLDEFFTEEEQIFSLLFPRTSSTLKRFYRGRIWYLDILCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CH10_RHILW
Sequence: MASTNFRPLHDRVVVRRVESEAKTKGGIIIPDTAKEKPQEGEIVAVGSGARDESGKVVALDVKAGDRILFGKWSGTEVKIDGEDLLIMKEADIMGIIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODC_STRHE
Sequence: IVAVLHSSEGVAGTITFIADSQIPLTGPNSI
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAVN1_HUMAN
Sequence: MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPEEDAAALELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRRGSSPDVHALLEITEESDAVLVDKSDSD
What is the function of this protein?
Plays an important role in caveolae formation and organization.  Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876).  Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1).  Essential for normal oligomerization of CAV1.  Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop.  Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876).  The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity).
What are the official names of this protein?
Caveolae-associated protein 1, Cavin-1, Polymerase I and transcript release factor.
What is the protein family that this protein belongs to?
Belongs to the CAVIN family.
What are the subcellular locations of this protein?
Membrane, caveola. Cell membrane. Microsome. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity).
Protein: LIVJ_ECO57
Sequence: MNIKGKALLAGCIALAFSNMALAEDIKVAVVGAMSGPVAQYGDQEFTGAEQAVADINAKGGIKGNKLQIVKYDDACDPKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTARGYQLILRTTGLDSDQGPTAAKYILEKVKPQRIAIVHDKQQYGEGLARAVQDGLKKGNANVVFFDGITAGEKDFSTLVARLKKENIDFVYYGGYHPEMGQILRQARAAGLKTQFMGPEGVANVSLSNIAGESAEGLLVTKPKNYDQVPANKPIVDAIKAKKQDPSGAFVWTTYAALQSLQAGLNQSDDPAEIAKYLKANSVDTVMGPLTWDEKGDLKGFEFGVFDWHANGTATDAK
What is the function of this protein?
This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.
What are the official names of this protein?
Leu/Ile/Val-binding protein, LIV-BP.
What is the protein family that this protein belongs to?
Belongs to the leucine-binding protein family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RECF_CORJK
Sequence: MYVSNLRLSNYRSWEELDLQLSPGITIFSGPNGHGKTNIVEALGYLAHLSSHRVNSDAALVRRGEEIANISATAVNNGRELTAHLAIRARGSNRAHINRAAMNSQRDLLGVVRTTLFSPEDLALIRGEPEQRRHFLDAIMVARYPRLAAVKADYDKALRQRNALLRQSAFALRLVVGAPKGASHNLSEDIKADAESALATLDVWDSQLAALGAQIMSARVQIVHDLAPHLQQTYQSLAPQSRPAHMSYTSTIDVELADLGIRLGVSEPNQPTALLSPEIAEATLLQAFANKRPQEVERGTTLLGPHRDDVNLILGHQPAKGYASHGESWSFALSLRLAAFFMQRGDGVEPVVILDDVFAELDSSRRQHLVDLISSAEQVLITAAVDEDIPEALRDVAKIYTIDELKNSALSTAERAVKDGEADGD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BL1S5_CAEEL
Sequence: MATIPSVVREITLVGEQIFDHTQVVRAEIDRFVERFERNERHREFDGILRASHALVESSETPVEGLFDMGKMEHMTQCVDDITKKLQTLVEPKYQKEHDVYLEKVKEDQKKYVDVCREQAMNKMRSMTAHR
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S5 family.
Protein: AQPS_RHIME
Sequence: MQEFDLTRRCVAEALGTGLLVAAVVGSGIMADALTADDALALVANTIATGAILVVLVTILGPLSGAHFNPAVSLVFALSGRLTRRDCAAYVIAQVAGAIAGTALAHLMFDLPPLDMSMKVRTGPAQWLSEGVAAFGLVATILAGIRFHREAVPWLVGLYITAAYWFTASTSFANPAVALARSFTNTFSGIRPGDLPGFVIAELLGAVCALALMRWLLQPARPIIRQTSPETAP
What is the function of this protein?
Involved in resistance to arsenic.  Facilitates efflux of arsenite [As(III)].  Arsenate [As(V)] enters the cell through phosphate transport systems and is reduced to arsenite by the arsenate reductase ArsC.  Internally generated arsenite flows out of the cell by downhill movement through AqpS (PubMed:16199569).  Can also transport the highly toxic methylarsenite [MAs(III)] and the relatively non-toxic methylarsenate [MAs(V)].  May be a component of an methylarsenite resistance pathway in which methylarsenite enters cells via AqpS, is oxidized by ArsH to methylarsenate, which exits the cells via AqpS.  This pathway may confer a selective advantage for R. melliloti to grow in the presence of environmental methylarsenicals (PubMed:33418223).
What are the official names of this protein?
Aquaglyceroporin AqpS.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPE_ECO55
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKVVEALMARNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: RFA2_SCHPO
Sequence: MAYDAFGKPGYGPDFNSAFSPGMGGGAGFNEYDQSSQPSVDRQQGAGNKLRPVTIKQILNASQVHADAEFKIDGVEVGQVTFVGVLRNIHAQTTNTTYQIEDGTGMIEVRHWEHIDALSELATDTYVRVYGNIKIFSGKIYIASQYIRTIKDHNEVHFHFLEAIAVHLHFTQKANAVNGANAPGYGTSNALGYNNISSNGAANSLEQKLAEYSLTPAQMTVMQAIHSAPETNEGVHVRQLAQSVGPGIDLTAVTDFLQQEGIIYTTIDENHFKSVLQDQ
What is the function of this protein?
Binds to single-stranded sequences.
What are the official names of this protein?
Replication factor A protein 2, Single-stranded DNA-binding protein P30 subunit.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPI_COFAR
Sequence: MNVLANTLKGLYDVSGVEVGQHFYWQIGGFQVHGQVLITSWVVIAILLGSAAIAVRDPQTIPTGGQNFFEYVLEFIRDVSKTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGITKKGLSYFGKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RT16_MOUSE
Sequence: MVQLTTIFCKAYHGGHLTIRLALGGCTNRPFYRIVAAHNKCPRDGRFVEQLGSYDPLPNSHGEKLVALNLDRIRHWIGCGAHLSKPMEKLLGLSGFFPLHPMMITNAERLRRRRAREVLLASQKAESEAKETEAS
What are the official names of this protein?
28S ribosomal protein S16, mitochondrial, MRP-S16, S16mt.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RRS1_YEAST
Sequence: MSAEDYKNLPVTVEKPIPVVYDLGNLAAFDSNVLDKNDLDSSNARREEKIKSLTRDNVQLLINQLLSLPMKTTTESVGGTGGQSSVMTLLQLPDPTTDLPREKPLPKAKAMTKWEKFAAKKGIKPKERAGKMIYDEASGEWVPKWGYKGANKKLDDQWLVEVDDKVKGTDNELIDPRTLNRAERKRLVKKNEKQQRRNMKNAL
What is the function of this protein?
Required for ribosome biogenesis.
What are the official names of this protein?
Regulator of ribosome biosynthesis.
What is the protein family that this protein belongs to?
Belongs to the RRS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL14E_PYRAR
Sequence: MVKVIDIGRVVVKVLGREAGRKAVVVDVVDENYVLITGPKTLTGVKRRRVNINHIEPTDKKVEIKRGASDEEVIKAVEAAGLVEYMRERVKPKMLGLTKAEVK
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: SNX12_HUMAN
Sequence: MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKVRQ
What is the function of this protein?
May be involved in several stages of intracellular trafficking.
What are the official names of this protein?
Sorting nexin-12.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
Protein: PYRC_CALS4
Sequence: MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHTHLRQPGFEEKETIRTGTESAAAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGIMKRVMTYGKMYDLLMITHCEDKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVELIRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMAPFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARILGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPYHGMKLKGVVEYTIVEGQIRYQKNKKFEKVEI
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: COX1_BUTBU
Sequence: MTFINRWLFSTNHKDIGTLYLIFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNMAHAGASVDLAIFSLHLAGVSSILGAINFITTAINMKPPALSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKVFSWLATLHGGTIKWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIALHDAYYVVAHFHYVLSMGAVFAILAGFTHWFPLLTGFTLHPTWAKAHFGVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTLSSIGSLISMTAVIMLMFIIWEAFASKRKILQPELTTTNVEWIHGCPPPYHTFEEPAFVQVQE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FLOA_BACSU
Sequence: MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIFTLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRANIELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANIERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEILSIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKVVEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  FloA and FloT function is partially redundant; double deletions have marked synthetic phenotypes (PubMed:20713508, PubMed:22753055, PubMed:25909364, PubMed:27362352).  Flotillins are thought to be important factors in membrane fluidity, especially during periods of rapid growth in rich media (Probable).  Whether specific proteins are associated with FMMs is controversial; in one study FloT rafts have been shown to include proteins involved in adaptation to stationary phase, while FloA-FloT rafts include proteins involved in differentation including sporulation, biofilm formation and DNA uptake competence (PubMed:25909364).  Another (more finely resolved) study only showed association of NfeD2 with FloT rafts of all the proteins examined (PubMed:27362352).  Involved in spatial organization of membranes, perhaps recruiting proteins to specific membrane regions (PubMed:23651456).  Simultaneous overexpression of both FloA and FloT leads to defects in cell division and differentiation, in part caused by stabilization of FtsH and its subsequent increased ability to degrade proteins.  Cells make more biofilm, are about half as long, have less EzrA and more frequent Z-rings (PubMed:24222488).
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Note=Present in detergent-resistant membrane (DRM) fractions, approximately 6 dynamic foci per cell; sometimes colocalizes with FloT in DRMs (PubMed:20713508, PubMed:22882210, PubMed:23651456). Found in discrete, highly mobile foci, rarely colocalizes with FloT (PubMed:22753055). At the septa colocalizes with FloT and FtsH (PubMed:22882210). Careful analysis gives an average of 13 FloA and 6 FloT foci per cell; FloA foci are smaller that FloT foci (PubMed:25909364). Another study shows FloA and FloT foci are similar in size, forming membrane assemblies of 85-110 nm, but FloA are more mobile than FloT foci. This study found no evidence of colocalization of FloA with FloT (PubMed:27362352).
Protein: RSMA_THET8
Sequence: MSKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGALTRALLEAGAEVTAIEKDLRLRPVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPYHIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAYGVLTLRVAHHAVAERLFDLPPGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEALRALGLPPRVRAEELDLEAFRRLREGLEGAV
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIN1_HUMAN
Sequence: MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE
What is the function of this protein?
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation.  Can affect Ras signaling at different levels.  First, by competing with RAF1 protein for binding to activated Ras.  Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling.  Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
What are the official names of this protein?
Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1.
What is the protein family that this protein belongs to?
Belongs to the RIN (Ras interaction/interference) family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.