PharMolix/UniProtQA huggingface dataset:
Protein: SIM20_MOUSE
Sequence: MAAARNLRTALIFGGFISMVGAAFYPIYFRPLMRLEEYQKEQAVNRAGIVQEDVQPPGLKVWSDPFGRK
What is the function of this protein?
Peptide involved in a broad spectrum of regulatory functions (PubMed:25687846, PubMed:26505917, PubMed:27268078).  Is a ligand for GPR173 (By similarity).  As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:27268078).  More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (PubMed:27268078).  Plays a protective role in memory retention through activation of GNRHR (PubMed:26505917).  Regulates the secretion of AVP by hypothalamic neurons (By similarity).  Plays a role in the transduction of the itch sensation (PubMed:26415767).  Induces anxiolytic effects, reducing behavior associated with anxiety (PubMed:25687846).  Regulates food intake as well as satiation and satiety by increasing Nucb2 expression in neurons (By similarity).  In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929).  It also increases the production of estradiol (E2) (PubMed:30933929).  In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (By similarity).  It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity).  Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651).  In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055).
What are the official names of this protein?
Small integral membrane protein 20, Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa, MITRAC7.
What are the subcellular locations of this protein?
[Small integral membrane protein 20]: Mitochondrion inner membrane; Single- pass membrane protein. SUBCELLULAR LOCATION: [Phoenixin-14]: Secreted. SUBCELLULAR LOCATION: [Phoenixin-20]: Secreted.
Protein: KHDR3_MOUSE
Sequence: MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEGKEEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSAADYYDYGHGLSEDAYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY
What is the function of this protein?
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.  Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro (PubMed:19457263).  Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity).  Binds poly(A).  RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:15471878).  Involved in splice site selection of vascular endothelial growth factor (By similarity).  In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity).  Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members.  High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion.  Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects (PubMed:22196734, PubMed:23637638, PubMed:24469635, PubMed:27174676).  Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay (PubMed:25505328).  Can bind FABP9 mRNA (PubMed:19916944).  May play a role as a negative regulator of cell growth.  Inhibits cell proliferation.
What are the official names of this protein?
KH domain-containing, RNA-binding, signal transduction-associated protein 3, RNA-binding protein Etoile, Sam68-like mammalian protein 2, SLM-2.
What is the protein family that this protein belongs to?
Belongs to the KHDRBS family.
What are the subcellular locations of this protein?
Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
Protein: HEM1_ORYSI
Sequence: MMASTTSATAAGGAFAAAKTRAGSSAAGGGACARVAAGGRRRSGVVVRCDAGVEAQAQAQAVAKAASVAALEQFKISADRYMKERSSIAVIGLSVHTAPVEMREKLAVAEELWPRAISELTSLNHIEEAAVLSTCNRMEIYVVALSWNRGIREVVDWMSKKSGIPASELREHLFMLRDSDATRHLFEVSAGLDSLVLGEGQILAQVKQVVRSGQNSGGLGKNIDRMFKDAITAGKRVRCETNISSGAVSVSSAAVELALMKLPKSECLSARMLLIGAGKMGKLVVKHLIAKGCKKVVVVNRSVERVDAIREEMKDIEIVYRPLTEMYEAAAEADVVFTSTASETPLFTKEHAEALPAISDAMGGVRLFVDISVPRNVSACVSEVGHARVYNVDDLKEVVEANKEDRLRKAMEAQTIITQELKRFEAWRDSLETVPTIKKLRSYADRIRASELEKCLQKIGEDSLTKKMRRSIEELSTGIVNKLLHGPLQHLRCDGSDSRTLDETLENMHALNRMFSLDTEKAIIEQKIKAKVEKSQN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, chloroplastic, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KTHY_VIBVY
Sequence: MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHPGEHLHDMTELLLLYAARVQLVENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMKNLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEKMDISFFERTRQRYLELAKSDASIVTINAEQSIEQVANDIRSALNLWLEQLQD
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: YQGF_CUPPJ
Sequence: MPDGVGRELPRDGTVLAFDYGEKKIGVALGNFVTRHATALTILPNVSVEGRFQAVGELIREWTPVQLVVGMPVNPEGGEQPSMRLARRFGNQLNGRYSLPVEWVDERYSSRMAAMGGARRGELDAEAARIILQQYFDQLPL
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_ACTP7
Sequence: MTVSTFNRTWAKVIVNALLRYGVKHFCIAPGSRSTPLTLEALQLQQNQQAQCHSHFDERGLGFFALGIAKVTNDPVAIIVTSGTAVANLYPAVIEASLTHHKLIVLSADRPPELIGCGANQAIPQQGIFADYPIAGVNLPKPAEHYNAGWLVATIEQACVTQSQQGGVIHINAPFAEPLYEADENAIGTHPWLKPIQSWLINPQTKWINSQTIQSEVSMHENWDYWRTKRGVIVVGKLPVEQGIGIKAWAETLGWCLITDVQSCVDANLPYADIWLSNNTVHQRLLQADIVIQFGGQIVSKRVNKFLEAFKGEFWQVDEYSDYLNPFAHHQTRFVAKAHHFLRVHPPLRQKPWLLEPLALSQFCAGFIEQQVGGSLNEASLAHHIEEVLATSGNLFIGNSLFVRLVDALCKLPEGYPVYTNRGASGIDGLIATMAGVAKGSGQPTVGVIGDISALHDLNSVSLLNKISHPCILFVINNSGGAIFDMLPVEAQAKEQFYRLSHNYEFAPIATMFGIEYIRPFTWADLKAKLKLAYGRKGVTIVEIKVNDQDGSNLYKSLVKQISQAEIA
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RAC9_GOSHI
Sequence: MNTSRFIKCVTVGDGAVGKTCMLISYTSNTFPTDYVPTVFDNFSANVVVDGSTVNLGLWDTAGQEDYNRLRPLSYRGADVFLLAFSLISRASYENVHKKWIPELRHYAPNVPIVLVGTKLDLRDDKQFLSDNPGAISITTSQGEELKKMIGAVTYIECSSKTQQNVKAVFDVAIKIALRPPKPKRKPIKRRSCAFL
What is the function of this protein?
Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.
What are the official names of this protein?
Rac-like GTP-binding protein RAC9.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with the membrane when activated.
Protein: FABZ_RICPU
Sequence: MIIDITEIMDWIPHRYPFLLVDRVLKIDPNKSITGIKNVTVNEPQFTGHFPARPVMPGVLMVEAMAQLAAILVAKSLGSTKNKEVFLMTIENAKFRRIVQPGDTMHIHAVIDQQRANVWKFSSTVTVEGEIAAESKFTAMIKDKT
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCV_RALSO
Sequence: MAKKNAIQDFSGEIGIAALVVAVVALMVLPLPTMLIDALLGLNITLSVVLLMVTMYIPSATSLSAFPSLLLFTTLLRLSLNIASTKSILLHADAGHIIESFGKLVVGGNLVVGLVVFLIITTVQFIVIAKGSERVAEVGARFTLDAMPGKQMSIDADLRAGHLSPEEARKRRALLAMESQLHGGMDGAMKFVKGDAIAGLVITLVNILAGIVIGITYHNMTAGEAANRFAVLSIGDAMVSQIPSLLISVAAGVMITRVSDEEQAHKQSSLGMEIVRQLSTSARAMFTASALLMGFALVPGFPSFLFVALATLIFVFGYTLRNRAKEGDGDEGDALPALLREGSKGKAPTIAEQAPSFTVPVGVRLGAELAKGLDVPALDTAFQQGRHALAEALGLPFPGIAIWKADALQPDSYEVRVHDIPGEPVAVPDGHLLIPDLPEALRAQAVEAAGLPNHPAPHWIAPAHVAQDAALSATGQRVERVIADHVVHVLRRSAHLFVGLQETQWMLERVTTDYPGLVAEAQKAVPAQRIADVLRRLLEEQVPIRNMRAILESLVVWGPKEKDTLMLVEYVRGDLGRQIAHQATGGTRQMPAILLDLSVEQTVRQAIKPTPAGNFLTLDPQQVEAIIMRLRGIMQGNPVETPSALAIVTSMDIRRYVRRMIEPHLQALNVYSFQELGGYVDLRPVGKLVL
What is the function of this protein?
Involved in the secretion of PopA, a proteinaceous elicitor of the hypersensitivity response in plants.
What are the official names of this protein?
Hypersensitivity response secretion protein HrcV.
What is the protein family that this protein belongs to?
Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADH1A_MACMU
Sequence: MSTAGKVIKCKAAVLWEVMKPFSIEDVEVAPPKAYEVRIKMVTVGICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVEPGDKVIPLALPQCGKCRICKTPERNYCLKNDVSNPRGTLQDGTSRFTCRGKPIHHFLGVSTFSQYTVVDENAVAKIDAASPMEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAVYGGFKSKEDIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLRSGKSIRTILTF
What is the function of this protein?
Alcohol dehydrogenase.  Oxidizes primary as well as secondary alcohols.  Ethanol is a very poor substrate.
What are the official names of this protein?
Alcohol dehydrogenase 1A, Alcohol dehydrogenase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG8_CANAL
Sequence: MAKKKSTGPQPSLSSSPNGRAKVTAETITTTTTTTTDTTNSYSLLNIWVISLALKILLFIGYHSTDFDVHRNWLAITNKLPISQWYIENTSQWTLDYPPFFAYFEYLLSLLVPRFVANDGCLDIVEIGQYGLPTIYFQRLTVIISELVLFYALQTIVKTSPTLSAKRRMYVATASLALSPGLILIDHIHFQYNGMMYGILLLCINSARLQQYLSCGFWFSVLLCFKHIYLYLAPAVFIFLLRGYCLKFYWNKRKNFFINIFNFIQWINLFKLGSIVILVFIIAFGPFYNVLPQLISRLFPFSRGLTHAYWAPNIWAVYSFLDRILIQIYKKIPMSKYPLLKIFQFDPNSLNNDQLLKTSTRGIVGDIEFFILPNITPKLTFLLTLFYQIMALIPLFIQPTYRRFVGALTLCGYASFLFGWHVHEKAILLVIFPMTLLVARDQKLLTPFNLLVSCGYGSLFPLIFTCNEWLIKVVYTYTWYIIFYFNFRKVVRPSKNNIIGNGIGNGNGKGGGIILDRMVNLYILLFNVVVIITSLFDLFKHKYPVLQNFEFLNLMIYSVYCAIGIISSWNGFCWLYFIDDGIWNQDQ
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PPT1_SCHPO
Sequence: MAKEALELKNEANKFLKEGHIVQAIDLYTKAIELDSTNAILYSNRSLAHLKSEDYGLAINDASKAIECDPEYAKAYFRRATAHIAIFQPKEAVGDFRKALALAPSDPAARKKLRECEQLVKRIRFQEAIHNTEPPSPLANINIEDMDIPSDYDGVILEKQITKEFVEDMKERFCQGKKLPLKFAYSILRDLKELLEKTPSLIDIPVKGDETLVICGDTHGQYFDLLNIFKLHGPPSPTNKYLFNGDFVDRGSWSTEVAFTLYAYKLLYPDAVFINRGNHETDDMNKVYGFEGECRSKYNERTFNIFSETFSLLPLGSLISDSYLVVHGGLFSDDNVTLDQLRNIDRFSKKQPGQSGLMMEMLWTDPQPAPGRGPSKRGVGLQFGPDVSKRFCEANGLKAVIRSHEVRDQGYEVEHDGYCITVFSAPNYCDSTGNLGAVIKVKEDMELDFHQFEAVPHPNIRPMAYANGLLSGM
What is the function of this protein?
Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90.  Dephosphorylation positively regulates the Hsp90 chaperone machinery (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase T, PPT.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYC_SALAR
Sequence: MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHQDFDALNILRPDSEPRATHHIQEIIEITRTLIEKGHAYVADNGDVMFDVPTDPTYGQLSRQDLEQLQAGARVDVVDVKRNPMDFVLWKMSKEGEPSWPSPWGEGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGEYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDKSAAPAGGEAFEARFVEAMNDDFNTPEAYSVLFDMAREVNRLKSEDMTAANAMASHLRKISGVLGLLEQEPDAFLQSGAQADDGEVAEIEALIQQRLDARKAKDWAAADAARDRLTEMGIILEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL4_CANLF
Sequence: MGLTSQLIPTLVCLLALTSTFVHGHNFNITIKEIIKMLNILTARNDSCMELTVKDVFTAPKNTSDKEIFCRAATVLRQIYTHNCSNRYLRGLYRNLSSMANKTCSMNEIKKSTLKDFLERLKVIMQKKYYRH
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GST8_CAEEL
Sequence: MVHYKLSYFPIRGAGEVIRQIFVYAGQSFEDHRISIEEWAAVKPTTPFGQLPLLEVDGKVLPQSHSIARFLARQFGINGKCAWEEAQVNSIADQFKDYRNEVRPYVMVKMGFAEGDLDALSKDVFLPGFKKHYGFIYNFLKTAGSGYLVGDSLTFVDLLIAQHTADILSTDPALLEEFPQFKAHQEKVHSNANIKKWLETRPETQF
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Probable glutathione S-transferase 8, GST class-sigma.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Sigma family.
Protein: DEOC_PROMH
Sequence: MTDLTAAARLALSLMDLTTLNDDDTDEKVTKLCHQAKSPEGNTAAICIYPRFIPLARKVLREQGTPEIRIATVTNFPHGNDDLDIALAETNAALAYGADEVDVVFPYRALMAGNEQIGFDIVKACKDACAKAGALLKVIIETGELKDPALIRKASEISIKAGADFIKTSTGKVPVNATLESAELMLQVIHDMGVGKEVGFKPAGGVRTAEEAAQYLALANRIMGDNWVDARHFRFGASSLLGNLLATLGHGEQKSSSGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_TOLAT
Sequence: MKQLLDFIPLIIFFTVYKLHDIYAATGALMATTLLQMIVVWVMYKKLERSHWITLVLVLGFGAMTLFFHNEAFIKWKVTVLYAAFGSALWISQFLFRKPLIKKMLGKEMSLPDAVWNRINFSWGLFFWMVGALNVYIAFYLPTEIWVDFKVFGVLGLMLVSTLLTGIYIYRYLPTNNQQDKE
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YPR71_YEAST
Sequence: MQNGTEDKSNIPARSNDDVLPPLAVRLTMKVMRLIFIGKMFAYSFVPFPPFKLLTFDNTVGWFVAYSAIVSIWGFAVWMERGYRHKINLLPPRCTKIRCSRCNTRIRSPNWFKYKNWLYFFLLYVSLTTSNLIIQLASFMTEMSRRGISVPGTKDPGKRDYLGLIIPMRFIGAFIHYMTANLFKEYYLHNGPLEKNDRPSTDEKTSENETL
What are the official names of this protein?
Uncharacterized membrane protein YPR071W.
Protein: UBE3D_BOVIN
Sequence: MAAVAAEARVFLEVRRRLQSALLILGDSKEGGLPMAVSVTPSSLRMQSPGGCTELRLPAGVRLAPSTCRGLQHVPGDGLHLRLHARAESRPELISVFNQSSQDQECCTFYCQSCGEVIIRDRMLLRVLPLPGDNWGALVDEWCCHPDPFANKPLHPRENDCFTGDCFYLVNLKSDLWQPRPEGAPVETHHLSSENHLKLKPKANTKVICKRCKVMLGETVSSETTKFYMTEIIILPSERNFPIIPRSQFVQSVLAQCVVELSSARSTFRFTIQGHDDKVYILLWLLNSDSLVIESLGQYTNIKKFPVLEDVLKPDSNSACNAVKVLYQPCIKSRNAELSSLWENDLSVHSLTLPSTTCLELLLILSKSNATLPPSLRCMNSFQVAFLKM
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
What are the official names of this protein?
E3 ubiquitin-protein ligase E3D, HECT-type E3 ubiquitin transferase E3D, UbcH10-binding protein with a HECT-like domain, Ubiquitin-conjugating enzyme E2C-binding protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_HYDS0
Sequence: MKNDIFLKSLKKEPIARYPVWLMRQAGRYLPEYRAIRQKYKSFLDFCKNVEDAAIVSLQPVDILGVDAVIMFSDILVLLEPMGIKVSFEAGEGPVLDHNFDFKNLKSQGISGDLSYVFELLKVLKEKSPVPVIGFCGAPFTLASYVIEKESSRDFTKTKVFMYENQKDFHILMEKLSEALVEYIDHQIKSGADVIQIFDSWSMSLSRFAYKEYVYDYNAFIIKSIKQKHPNTPIIYFFRGSSSHIEDAVDLGADALSVDWSVCINDVCKRYPDLVFQGNLEPQILLLDKENIRKHVEEFVMCIPRDTAFVVNLGHGITPDVSKDNVKYFVECVKEVSYGKRNLFKKC
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_RHORT
Sequence: MKVLFVTSEAYPLVKTGGLGDVAGALPAALRDIGVDARILLPAYPDAMRRARLTGKTVPLGNPLGVGETRLLEGTMPDTGCPLWLLDCPAMYERTGGPYMMYSGVDWPDNFRRFALLSKVAAMIGTAGDLMDWRPDVLHGHDWQTGLVPAYLNAWGARRPPFLFSIHNMEYRGLFGPEILDLIGLPRSQFSINGLEFHGLVSTLKAGIVYAQAVATVSPSYAAEIKTPVGGQGLEGLLQARAGDLSGILNGIDSNAWNPQTDPYLAAPIDGADPAPGKRINKDMLKRRMGLDADGDRPLFGLVSRFVAQKGIDLVVAALPGMIAGGAQVAILGAGDTGLEAALNDIVGRYPGAAAVHVGYDEHLAHLIEGAADFLLVPSRFEPCGLTQLYALRYGTIPVVRRTGGLADSVSHLDDGPNGTGIVFDHALPDALEWAIGRAMTLYRDKATLNKVRQRGMSQDFSWKRSAKEYLRVYGSMVGGDVHRP
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: FTSB_ESCF3
Sequence: MGKLTLLLLAILVWLQYSLWFGKNGIHDYSRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTKPGETFYRLVPDASKRAQTAGQNNR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: VPC31_MYCTO
Sequence: MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity).
What are the official names of this protein?
Ribonuclease VapC31, RNase VapC31, Toxin VapC31.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: TIG_BUCAP
Sequence: MKFFIEKNKKNTDRVTINIPKKIVSNELIREFIEINKKTKINGFRKGKTPIKIIQEKYGNRVYYDVFNQLMQKFFYEFIKKEKIKIIGLPKYVMHENEDQKEYFKYSVNYEVYPKFEIKDVNLIKVEKIIVNIKDEDVKKNIEKTASYEKDIWNKVNRAIKTNDLVTINYCIYENNKKLDKFNVEKFKFIVSQNNFIPELNNKLINHFTNDVIFFKINFCKFHPEEELQGKDITFKIKILNVEEKQENIEIEKNIKTIKINKLSKLNYQTIKNNIIEKIKSLTQNHLQNQIIKQLIIKNPINIPPTLLREETNFLRNKFIKEYKEKQENILKKKYHTNLESKAKTRLHIKLIIEKIIRDNKISVNEEKVDLLIKKISLKYKKPLEIINIYKKNTMLRKTIKNIELEMQVMQFLIKKVKIIEKNWTLDEIMNYNWKNNEELFA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PLSY_BURL3
Sequence: MQILLAALVAYLIGSVSFAVVVSGAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWIAVWLARHLGLPDVAVAWVAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPVFDVFLFGTGHNPVAWAVLAMSVLLVWRHRGNISKLLAGQESRIGDKKKAAADGGAQDGGKA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.