PharMolix/UniProtQA huggingface dataset:
Protein: ATP6_HAEDU
Sequence: MAVNTAEYIGHHLSFLSSGDGFWAVHLDTLFFSLVAGVLFLVVFSRVAKNATTGVPGKLQCLVEMVVEWVDGLVKDNFHGPRHMIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIHYLRAVPTADISATLGMSICVFGLILFYTVKSKGFNGLAKEYTLHPFNHWAFIPVNFILETVTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITLQAFIFMMLTIVYLSIAYNKADH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA2_LEGPH
Sequence: MSEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFPGGVYGLALNLERDSVGAVILGDSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPIDGKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAMIPVGRGQRELIIGDRQTGKTAIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQYIAPYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSRLLERAARINADEVEKLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLDVDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLALAQFRELEAFSQFASDLDDATRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMRSTHAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PSBC_COFAR
Sequence: MKTLYSLRRFYHVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPGIIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRALVWSGEAYLSYSLGALSIFGFTACCFVWFNNTVYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFFFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TBB9_GOSHI
Sequence: MREILHIQGGQCGNQIGAKFWEVVCAEHGIDSTGRYGGDSELQLERINVYYNEASCGRFVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRTMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMVCAADPRHGRYLTASAVFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSTVCDIPPIGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESDMNDLVSEYQQYQDATADDEEYEEEEEYEAEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-9 chain, Beta-9-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PRR5_HUMAN
Sequence: MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV
What is the function of this protein?
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.  mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.  PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling.  May act as a tumor suppressor in breast cancer.
What are the official names of this protein?
Proline-rich protein 5, Protein observed with Rictor-1, Protor-1.
What is the protein family that this protein belongs to?
Belongs to the PROTOR family.
Protein: KDM2A_HUMAN
Sequence: MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.  Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'.  May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation.  Required to maintain the heterochromatic state.  Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere.  Required to sustain centromeric integrity and genomic stability, particularly during mitosis.  Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310).
What are the official names of this protein?
Lysine-specific demethylase 2A, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Chromosome. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597).
Protein: DPO4_ACIAD
Sequence: MRKIIHIDMDAFYASVELRERPELKTLPVVISSHHPRAVIAAASYPARVYGLRSAMPMGQARKLCPDLIIIEPNFDKYRAVSHQIHQIFQQHTHIIEPLSLDEAYLDVTENLNNLPSATDVAIQIRQQIWEQTSLTASAGVAPNKFLAKIASDWNKPNGLCVIKPHQVMQFIQNLPLKKIPGVGRVTQDKLQQLKLETLGDLQHIEEAVLIQHFGKYGKQLYLYAQGIDHRSVQAERVRQQISKETTFDQDLYLHECSSYWLMLAEKVWQSLQNKNLQARGVNIKLKNKHFQVFQHSKSFKRALQSLDEFKSVLALLLQEISLTLDDQYRLIGVGLYQLSPSASESQLTLW
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COOMT_COPJA
Sequence: MDTPNTFQNDDEIKAQAQVWKHMFGFAETIMLRSTVSLGIPDIIHNNGPVTLSQLVTHLPLKSTSIDRFHHFMRYLVHMQLFTISTDQITKEDKYELTPASKLLVHGHQKSLAPYVMLQTHPEEFSVWSHVINVLDGKKPYWESNDTSMYEKTEGDPEINEILNDAMTSHSTFMLPALVSGLMKENVLDGVASIVDVGGNSGVVAKGIVDAFPHVKCSVMDLNHVIERVIKNPKLDYVAGDMFTSIPNADAILLKSTLHNYEDDDCIKILNIAKEALPSTGGKVILVEIVVDTENLPLFTSARLSMGMDMMLMSGKERTKKEWEDLLRKANFTSHQVIPIMAIESIIVAYS
What is the function of this protein?
Catalyzes the conversion of tetrahydrocolumbamine to (S)-tetrahydropalmatine and of columbamine to palmatine, an isoquinoline alkaloid.
What are the official names of this protein?
Columbamine O-methyltransferase, CoOMT, Tetrahydrocolumbamine 2-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: CNDG2_XENLA
Sequence: MSKREAFLQATAKDSVEDFLSFIQLHKDVSDPFDLNELLQELSRKQKEELWEKLKTLLTEALVANPVERWQNIDDDSDDDMEVESSSDVKQTMCVIHGVTIAAAASLCVIDEDVCYETLLECAAILSGIVHALPKSESHITLAIRHLCEAWWEKGLQGKEEFGKTAFLLLLAKSLEVKCVVADIGRLWHLHQTLLSFDFNSEESHNVKDLLLQCFLSINHIKKEEGRRFLSFLFSWDVNFIKMIHGTIKNQLQCLPKSLMTHIADIYFRAWKKASGDVLQTIEQSCIQDFMHHGVHLPRNSPLHPKVREVLSYFHQQKLRQGVEEMLYNLYQPIIWRGLKARNSEVRSNAALLFVEAFPIRDPNLNHEDMDNEIQKQFEELFNLLEDPQPLVRSTGVLGVCKITAKYWEMIPPAILTDLLRKILGDLAADVSSADVRCSVFKCLPILLDNKLSHPLLENMLPALKFCLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICPMEQILARLEVDSRPVSRRIVNLLFNSFFPVNQQEEVWCERCVALIQMNPAAARKFYQYAYEHTAPTNIAKLMLTIRRCLNACINRTVPNEDTEDEDDDEGDGEGIVRGDSEKENKSVLENVLSTEDSASMASLLEIVVVLWRSIRKALDQNEEAKTYTISKFASVLPEYFKAFKEERCTVPLIILASFMPPAAVPTFSCSVLSKLRHLDSGADEQKYSTLIDCLCRWGQVGHVLELASEWLSESYPEKRGRKDSNRQVRIQDTMESKPALALDYIEYIMTHTMNRDCLLSLQTKKLNQLLKVLGLVKEVLFCYIKPSEAVTHNVNQDTALRAFSLYCRLSIHLQHKFSSEGRTYLSVLEDTGGWIESQVLPTLESNQDISEEPRNMCHQILKAYLTVCKDVLMVGLADSEFQAQLLQITLSVIQTEKCHNCLPMLFYVLKEITELCLAHKMSDASVECDEMLDAIQKAFHKSLETVARRLRKQREEALQLLQTIQLPLGEFVHTVQCWHTASKVLHRGTLSTLLAAVVVEISHSLRKITDLSELTPPSSISDLPPLSKCIMTIIVKSPSAVSSFLDELTECITLEEVEGILSLTAALYVAVVSSKRKQIPPAVKNTASAIYRKLKNFCEVTMDDAGSIERAVYESSMRILNEMLHPS
What is the function of this protein?
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
What are the official names of this protein?
Condensin-2 complex subunit G2, Chromosome-associated protein G2, Non-SMC condensin II complex subunit G2, XCAP-G2.
What are the subcellular locations of this protein?
Nucleus.
Protein: NHAP2_SALSV
Sequence: MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPFAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQKHETGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTALEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAVPALILSIWMIFFARPLSVFTGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWPVSRVGLDIHPDNPWEQFIYQLSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALGKLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAAPVVGDQVEFGGMIWTVAEKEDNVVRKIGVRVAEDEAE
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMJ_ACTPJ
Sequence: MTIQLINESSNTEKFQQICDKWRLVHDRSAILALVLTDERLELRKLDEPKLGAIAVNFVDGTMAHRRKFGGGRGEAVAKAVGIKGDYLPTIIDATAGLGRDAFVLASVGCKVLLVERNPIVAALLEDGLVRAYADPEIGAFMQERMILADVRDISLLDVAQQAADVVYLDPMYPHKQKSALVKKEMRVFQHLVGADLDSDNFFVPAKALARKRVVVKRPDYAPFLAEQKPDFSQTTKNHRFDVYLSHLKSA
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_CHLTE
Sequence: MSKKSGRNIKPGELNLKEKLVHINRTAKVVKGGKRFGFNAIVVVGDKEGHVGYGLGKANEVQDAIAKGVEDGKKNVIKVPIVKGTIPHPIVAKYGSAKVLMKPATPGTGLIAGGAVRAVLEMAGIHDILTKSLGSSNPHNVVKAAIKGLQNISDANDVAERRSKSLKEVFES
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: NPHP4_MOUSE
Sequence: MGDWHRAFTQNTLVPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDREGVGLLDSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADGGASSPTSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLPPSRSRVISNDGASFFSGGSLLIPGGPKRKRVVQAQRLADVDSELAAMLLTHTRAGQGPQAAGQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSLAPQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPLWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ
What is the function of this protein?
Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module.  Does not seem to be strictly required for ciliogenesis (By similarity).  Required for building functional cilia.  Involved in the organization of the subapical actin network in multiciliated epithelial cells.  Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity).  In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins.  Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity).  Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity).
What are the official names of this protein?
Nephrocystin-4, Nephroretinin.
What is the protein family that this protein belongs to?
Belongs to the NPHP4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:29899041). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions (PubMed:21565611). Localizes to the ciliary transition zone (PubMed:21565611).
Protein: GYRB_ORYSJ
Sequence: MGPLLRSSPPPRHLRLLLRRLLSTAAGRPSRLLPLPASSSARLLVRPRVAVAAAAAGAPLRRNGVAVRAFMASTAASEAMQEKRVAGEYTAANVQVLEALDGVRTRPGMYIGSTGSRGLHHLVYEILDNAVDEAQAGYATKVDVILHGDNSVSVTDNGRGIPTDIHPQTKKSCVETVLTLMHAGGKFGGSKSGYTVSGGLHGVGLSVVNALSEALEVTVWRDGKEYRQNYSRGKAITMLTSRTLSDESSSRQGTRIRFWPDKHIFTTTMDFDFNTIAGRIRELAFLNPELTIALTKEEDDLQVQHNEYCYAGGLVEYVKWLNTDKKSLHDPIAFRKEMDGITVDVSLQWCSDSYSDTVLGYANSIRTIDGGTHIDGLKTSLTRTINNFAKKSKTLKDKDISLSGEHVREGMTCIIAVKVPNPEFEGQTKTRLGNPEVRRIVEQSVQENLTEYLELHPDVLDSILSKSLNALKAALAAKRARELVRTKSVLKSSSLPGKLADCASSDPEESEIFIVEGDSAGGSAKQGRDRKFQAILPLRGKILNIERRDEAALYKNEEIQNLIVALGLGVKGEDFNKEALRYHKIVILTDADVDGAHIRTLLLTFFFRYQKALFDEGCIYVGVPPLYKVERGKQAHYCYDDADLKELVNTFPTNASYHIQRFKGLGEMMPAQLWETTMDPERRMLKQLKVEDAAEANVVFSSLMGTRVDVRKQLIQNAASMVNLEHLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B, chloroplastic/mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: MARH6_PONAB
Sequence: MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQRTHEAVAEGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVVFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation.  Promotes ubiquitination of DIO2, leading to its degradation.  Promotes ubiquitination of SQLE, leading to its degradation.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.  May cooperate with UBE2G1.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF6, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, RING-type E3 ubiquitin transferase MARCH6.
What is the protein family that this protein belongs to?
Belongs to the DOA10/MARCHF6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NACA_DEBHA
Sequence: MSIEEIPQGADVSILSKNEKKARELIKKLNLKQIKGITRVTFKQRGNLIYAIDQPDVFRSSAGTYVVFGEAKVDDMNKRIAEAQQQQAQQDALSKAAGETGEAGEEDKSQDAITADLEKASLNTNKIEEEEADDGEVDESGLDAKDIDIIVEQTQVSRAKAVKALRVHDGDMVNAIMELS
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD2 may also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: PYRF_MARN8
Sequence: MQNLNDPKIIVALDFPSQNPALALADQLDPAKCRLKVGKELFTRSGPDLVKALQSRGFDIFLDLKFHDIPNTTSAAVAAAAELGVWMVNVHASGGEKMMVACRERLESFGNDRPLLIAVTVLTSMSDEDLAGIGIASSAEAHVSRLATLTKNSGLDGVVCSAQEAPRLKAEQGSDFQLITPGIRPLTADKGDQQRIMTPTDALKAGSDYLVIGRPITQAPDPLAALESIHAEVVAV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: SPX1_ARATH
Sequence: MKFGKSLSNQIEQTLPEWQDKFLSYKELKKRLKLIGSKTADRPVKRLRLDEFSVGISKEEINFIQLLEDELEKFNNFFVEKEEEYIIRLKEFRDRIAKAKDSMEKMIKIRKEIVDFHGEMVLLENYSALNYTGLVKILKKYDKRTGDLMRLPFIQKVLQQPFYTTDLLFKLVKESEAMLDQIFPANETESEIIQAELSEHKFMESLHMKSTIAALRVLKEIRSGSSTVSVFSLPPLQLNGLDETWKKIPLLEQEAK
What is the function of this protein?
Plays a positive role in plant adaptation to phosphate starvation (PubMed:18315545).  Inhibits PHR1 DNA-binding activity in a Pi-dependent manner (PubMed:25271326).
What are the official names of this protein?
SPX domain-containing protein 1, Protein SPX DOMAIN GENE 1, AtSPX1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRF_BEII9
Sequence: MSAEFDISDLKRRMQGAIATLKHELGGLRTGRATASLLEPVHVDAYGQSLPLNQVATISVAEARMLSVQVWDKGMVGPVDKAIRDSNLGLSPTVEGQILRIRIPELNEQRRKEMAKVAHKYAEEAKVAVRHVRRDGIDTLKKLLKDKAIGEDDEKRHAAEIQKVTDQFVGEVDQALAAKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.