PharMolix/UniProtQA huggingface dataset:
Protein: CH10_SALA4
Sequence: MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4MA_SINFN
Sequence: MSKAIRIARLTSATCEQIQARMLEACRQIASDHGLVIESAGWRGLEPGFSFEPAFRISIPAPDGKPLNLDREMFAVLAEQYGLEAADFEREFIAGGERFRITGIDPRRPKYPISVERIPDHRGFKFTADNVAMLLKAQAKP
What are the official names of this protein?
Uncharacterized protein y4mA.
Protein: VP7_ROTBU
Sequence: MYGIEYTTILIFLTSITLLNYILKSITRIMDYIIYRFLLIVVVLATMINAQNYGVNLPITGSMDTAYANSTQSEPFLTSTLCLYYPVEASNEIADTEWKDTLSQLFLTKGWPTGSVYFKEYTDIAAFSVEPQLYCDYNLVLMKYDSTQELDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTVKVCPLNTQTLGIGCLITNPDTFETVATTEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAIIQVGGANVLDITADPTTAPQTERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: TRHO_SHEB9
Sequence: MTKVVVCALYKFVSLPHFESIRAPLLAMMEQAEIKGTLLLASEGINGTVAGTQEAIEALLVWLNSQNGLDNIVHKLSFDDEMPFYRTKVKLKNEIVTMGVEGIDPLKVVGTYVKPQDWNALISDPDVILVDTRNDYEVQIGTFKNAVNPVTETFREFPEYVKQNLDPAKHKKVAMFCTGGIRCEKSTAYLKEQGFDEVYHLEGGILKYLEEVKAEESLWEGECFVFDNRVAVNHDLKKGQYDQCNACRMPITEAEKQSPAYVQGVSCPHCIDKISDEQRKRFVERERQVNLAKARNEAHIGSDVNQVIEARREKKEAQRRLAAEKNNAKKSQVL
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: YGL4_SCHPO
Sequence: MGFPLEKSEDEWKKELGPEKYRIMRQKGTEHPGAGRFTHQFPKQGVFVCAACKELLYKASTKFESHCGWPAFFDNLPGKVKRIEDNSYGMHRVEAVCANCGGHLGHIFKGEGYSNPTDERHCINSASLEFHNEATNDN
What are the official names of this protein?
Uncharacterized protein C216.04c.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FENR_DELAS
Sequence: MQDTSGTQPIQTDALVIGAGPAGLFQVFQLGLQGIRCHVVDALPHVGGQCAQLYGDKPIYDIPGIPVCTGHELVQLLQRQVAPMDAQLHLSQQVSQLQRMDDGRWLAQTTHGLELHARSVFIAAGVGAFVPKALKVPGVELLAAGQLHYHPADLEMVRGQTAIVHGGDEEAVAAAIACADRAQATYLLYRRDAFQASAVLLERLQELRDSGAIRVVIGQITQLHADAGQLRAVQWMDGEGQEHELAAQQLVVCLGISPRLGPVAEWGLAMERKQLLVNPATQATDAPGIYAIGDIVSYPGKHKLILCGFHEATMAAFAAAEYLQGEKPLLQYTTTSARLHAILGVSHPQA
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: IF2_SHEDO
Sequence: MADTSVQKLAAEVGKSVERLIEQFSEAGLKKGQADTVSETEKQQLLDYLKKQHGADKAPTKMTLQRKTVSTLSVPAGGGQSKDVKVEVRKKRTFVKRDDSELVDQAELEAKAKAEADAKAAAEAKQKADAEAQAKAAAEAKAKAEANKAKEKAPQAPAPKPKAELKAETPEAAAARAEAERIKATQEAVLTKKQKEEAAQAAEEAKKLAEVNSKRWAEEERLRLEAEKNGDHHVTTSKVARAAEDSSDMDDEKRGRRARNKPTNKKRGGKDARDGREKHMRNRSTAPQSMAHGFNKPVAAVSRDVRIGETVSVAELAHLMAVKATEIIKQMMKMGSMVTINQILDQETAQMVAEEMGHKVVLLRENELEEQVLGDRDDNVKLETRAPVVTIMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTSMRARGAKATDIVILVVAADDGVMPQTIEAIQHAKAGNVPLIVAVNKMDKPDADPERVKSELSQHGVMSDDWGGDNMFVHLSAKTGEGVDELLEGILLQSEVLELKAVREGMAAGVVIESQLDKGRGPVATVLVQSGTLRQGDIVLCGLMYGKIRAMKDENGNAITEAGPSIPVEILGLSGVPSAGDEATVVRDERKAREVALYRQGKFRDVKLARQQKSKLENMFANMEEGEVQELNIVLKADVQGSLEAICDSLTGLSTAEVKVNIIARGVGALTETDATLAAASNAIMVGFNVRADAQARKTIEAESVDLRYYSIIYNLIDEVRAAMTGMLAPEFKQQIIGLAEVRDVFKSPKIGAIAGCMVTEGIVKRSAPIRVLRDNVVIYEGELESLRRFKDDATEVRNGMECGIGVKNYNDVRVGDQIEVFETIEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRR_ORYSJ
Sequence: MDATTTAKRKRPAASDIADDAPTTVDEVSDAEVEEFYAILRRMRDATRRLGARPPPPRAPAWRPSFSWEDFADAPPKQAPPPPQQPADHERVAENATPPRRPAPGLDLNVEPPSDAPATPRSARAPA
What is the function of this protein?
Acts as negative regulator of disease resistance.  Acts on basal resistance, age-related resistance and resistance mediated by the LRR receptor kinase XA21.  Plants over-expressing NRR display enhanced susceptibility to the bacterial blight Xanthomonas oryzae pv.  oryzae (Xoo) (PubMed:16115061).  Binds to and represses NPR1/NH1-mediated transcriptional activation of LG2 in vitro (PubMed:22353606).
What are the official names of this protein?
Protein NEGATIVE REGULATOR OF RESISTANCE, NPR1-interactor.
What is the protein family that this protein belongs to?
Belongs to the NPR1-interactor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLNA1_PEA
Sequence: MSLSDLINLDLSGTTEKIIAEYIWIGGSGLDLRCKARTLPGPVTDPSELPKWNYDGSSTGQAPGQDSEVILYPQAIFKDPFRRGNHILVMCDAYSPAGEPIPTNKRHAAAKVFSHPDVVAEETWYGIEQEYTLLQKDINWPLGWPAGGYPGPQGPYYCSVGADKAFGRDVVEAHYKACLFAGINISGINGEVMPGQWEFQVGPSVGISAGDEIWVARYILERITEVAGVVLTFDPKPIKGDWNGAGAHTNYSTKSMREDGGYEIIKKAIEKLGKRLPEHISAYGEGNERRLTGKHETADINTFSWGVANRGASVRVGRDTEKEGKGYFEDRRPASNMDPYVVTSMIAETTILLKP
What are the official names of this protein?
Glutamine synthetase nodule isozyme, Cytosolic GS1, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_ECOLI
Sequence: MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR
What is the function of this protein?
In the E. coli 70S ribosome it has been modeled (PubMed:12809609) to contact the 23S rRNA of the 50S subunit forming part of bridge B4.  In the two 3. 5 A resolved ribosome structures (PubMed:16272117) there are minor differences between side-chain conformations.
What are the official names of this protein?
30S ribosomal protein S15, Small ribosomal subunit protein uS15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PGTS_PELAC
Sequence: MEQYYMVIDVAKCQDCNNCFMGCMDEHELNEWPGYTASMQRGHRWMNIERRERGTYPRNDINYRPTPCMHCENAPCVAKGNGAVYQREDGIVLIDPEKAKGKKELLDTCPYGVMYWNEEENVAQKCTMCAHLLDDESWAPKMPRCAHNCGSFVYEFLKTTPEAMAKKVEEEGLEVIKPELGTKPRVYYKNLYRFEKNYVTAGILVQGDCFEGAKVVLKSGGKEVASAETNFFGEFKFDALDNGEYTVEIDADGKSYSDTVVIDDKSVDLGFIKL
What is the function of this protein?
Isomerization of pyrogallol to phloroglucin.
What are the official names of this protein?
Pyrogallol hydroxytransferase small subunit, Transhydroxylase subunit beta.
Protein: NAGZ_HAEIN
Sequence: MSSLLIDLKGKELEQEEVELLSHPLVAGLILFTRNFENREQIQELIRSVRQRVKKPLLITVDQEGGRVQRFRDGFTMLPSMQAFQETLSATEQVSFAKEAGWQMAAEMIALDIDLSFAPVLDLGHECRAIGDRSFSSDVKSAVNLATAFIDGMHQAGMASTGKHFPGHGHVLADSHLETPYDDRTKEEIFSGDLQPFQQLISQNKLDAIMPAHVIYSQCDSQPASGSKYWLKEILRKKLNFQGTIFSDDLGMKGAGVMGNFVERSKKALNAGCDLLLLCNEREGVIQVLDNLKLTENQPHFMARQARLQSLFKRRVINWNDLISDQRWRLNYQKLADIQSRWLDIQAAKND
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP10_FDVS
Sequence: MTSISLTIAPDLIHCGVPQRLSDTIILNDKPKITLLSYFDNIFTEANIIKAPKEHSVQSTVNIYVKLELLKRLYDRLQSVDTSTLPYISQIKEALRSFLHNDIQYVFTRIPDSEIDGNYVGVTTHGLSLFANAKNDAEEIERVQIDTPTEGNLTLKPISADGVEVVLDDSYINAVSKVIGPDVHKLIDKCCKEFPAHVGTILEEVKYCLILGKLRLAGGYDYNCPSSTTDVTRYGDFDKFRIKMFNKLTRFYNVSLALVPCNKLKMQYIFDSESEKINGDRTFLDQAWPAITSFIETHDLATKVKTDDPDTYVLKEVKSCKINSSTKQATLVNLDGNKLEWYKNNIYNAKLEDGIVINRELYEKAADKSYIKYNVKVVFASYALQKIIDEKSDKSITVDTSAGEMTLDKYRAIANVLNSIWKRGKDMAIKYFDYIKMGIEKATHLSLNLMKKYNITLDDVVSFIEKGPGYLATLQKLNDYKLIAKIIICHILPTIIQCVYKSDPNSKIMNSTLITNAVNLIRQDTKRYESSTGRKDANLVTHDASSLPLIRIYKT
What are the official names of this protein?
Putative outer capsid protein p10.
What are the subcellular locations of this protein?
Virion.
Protein: NU5C_OLIPU
Sequence: MEHTYQYSWIIPFIPLPVPILLGVGLLLFPTATKNLRRMWTFLSIFLLSIVMIFSLYLSIQQIFLSCIHQNVWSWTINNEFSFEFGYFIDPLTSIMSILITTVGILVLIYSDNYMSHDQGYLRFFAYMGFFNTSMLGLVTSSNLIQVYFFWELVGMCSYLLIGFWFTRPIAANACQKAFVTNRVGDFGLLLGILGLYWITGSFEFQDLFEIFKNLILNNRVNLLFLTLCAFLLFVGPIAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFIVIPSIMYIISLIGIITVLLGATLALAQKDIKRGLAYSTMSQLGYMMLALGMGSYRSALFHLITHAYSKALLFLGSGSIIHSMEAIVGYSPDKSQNMILMGGLTKHVPITKTAFLIGTLSLCGIPPLACFWSKDEILNDSLLFSPIFAIIACSTAGLTAFYMFRIYLLTFEGHLNTFFLNYSGKKSSSFYSLSLWGKEEEKKLNKNFGLVPLLTMNNTKRASFFCNKTYKISNNVRNQIFITVENFGLNTKTFYYPHESDNTILFPMLILLLFTLFIGAIGIPFNQEGIDFDILSKLFTPSINLLHKNSQNFVDWYEFLRNATFSVSIAFFGIFIAYCLYKPFYSSLLNLTLLNSFQKMNSKRIRWEKLINFVYNWSYNRGYIDAFFKTSLIESIRRLAKQTNFFDKRIIDGITNGVGITSFFVGEVTKYIGGSRISSYLFLYLSYVLIFLMILLFFYFEKF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NIKB_STAA3
Sequence: MFIIKSMLYRLMQMIVVLFVISTLTFILMKLSPGNPVDKILHLDVAQVSTEQINATKDKLGLNDSLLVQWWHWMNHLLHFNLGKSFESKEPVTQILFNYAPITLLISFSTLVVSLCISIPLGIIAAKRFHKWTDKVIRVISTLSISLPAFFIGIILLFIVTNLMNIDSVILSQFILPVITLSLGMCAYIIRLVRSNLLMLLQSNIVQASRLRGMNERYILIHDLLKPTILPIIPLLGISLGSLIGGTVVIENLFDIPGIGYLLMDSIKSRDYPVIQGCVLFIGFFVVIINTIADLLTLLLDPKQRLQLGNPKIKTNTPLISESSDRHA
What is the function of this protein?
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Nickel import system permease protein NikB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATK_NICGU
Sequence: MEEIQRYLQPDRSQQHNFLYPLIFQEYIYALAHDHGLNRNRSILLENPSYNNKFSLLIVKRLITRMYQQNHFLISTNDSNKNSFLGCNKSLYSQMISEGFAFIVEIPFSLRLISSLSSFEGKKIFKSHNLRSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYWNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYQGKSILASKGTFLLMNKWKFYLVNFWQCHFYLCFPTGRIHINQLSNHSRDFMGYLSSVRLNPSMLRSQMLENSFLINNAIKKFDTLVPIIPLIGSLAKANFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCIHDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y681_RICCN
Sequence: MAGHSKFKNIQHRKGAQDKKRAKVFTKLIREIVTAAKTGSSNNPENNPRLRNALTAARSQNLPKERIDKAINSANDSSNNENYTEIRYEGYAPNGIAIIVEALTDNKNRTAAEVRSSFTKYGGSLGETGSVNYLFNHCGVIQYPINIASNKDILEAVIEAGGHDIISDDTTHTIYTDIENFSKVLEFLTGKYGIPEDSYIGWIPLNTIIIDDKEKAEKLLKLVEVLEESDDVQRVFGNYELSDDVYEIIQGEP
What are the official names of this protein?
Probable transcriptional regulatory protein RC0681.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA_SALPA
Sequence: MSFWVEVSLNTPAQLSLPLYLPDDETFASFWPGDNASLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECVAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDHASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: TRFE_PIG
Sequence: VAQKTVRWCTISNQEANKCSSFRENMSKAVKNGPLVSCVKKSSYLDCIKAIRDKEADAVTLDAGLVFEAGLAPYNLKPVVAEFYGQKDNPQTHYYAVAVVKKGSNFQWNQLQGKRSCHTGLGRSAGWIIPMGLLYDQLPEPRKPIEKAVASFFSSSCVPCADPVNFPKLCQQCAGKGAEKCACSNHEPYFGYAGAFNCLKEDAGDVAFVKHSTVLENLPDKADRDQYELLCRDNTRRPVDDYENCYLAQVPSHAVVARSVDGQEDSIWELLNQAQEHFGRDKSPDFQLFSSSHGKDLLFKDSANGFLKIPSKMDSSLYLGYQYVTALRNLREEISPDSSKNECKKVRWCAIGHEETQKCDAWSINSGGKIECVSAENTEDCIAKIVKGEADAMSLDGGYIYIAGKCGLVPVLAENYKTEGENCVNTPEKGYLAVAVVKKSSGPDLNWNNLKGKKSCHTAVDRTAGWNIPMGLLYNKINSCKFDQFFGEGCAPGSQRNSSLCALCIGSERAPGRECLANNHERYYGYTGAFRCLVEKGDVAFVKDQVVQQNTDGKNKDDWAKDLKQMDFELLCQNGAREPVDNAENCHLARAPNHAVVARDDKVTCVAEELLKQQAQFGRHVTDCSSSFCMFKSNTKDLLFRDDTQCLARVGKTTYESYLGADYITAVANLRKCSTSKLLEACTFHSAKNPRVETTT
What is the function of this protein?
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.  It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization.  Serum transferrin may also have a further role in stimulating cell proliferation.
What are the official names of this protein?
Serotransferrin, Transferrin, Beta-1 metal-binding globulin, Siderophilin.
What is the protein family that this protein belongs to?
Belongs to the transferrin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRTFA_HUMAN
Sequence: MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL
What is the function of this protein?
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645).  The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics.  MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex.  Activity is also regulated by filamentous actin (F-actin) in the nucleus.
What are the official names of this protein?
Myocardin-related transcription factor A, MRTF-A, MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (By similarity). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (By similarity). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (By similarity). Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear actin, which decreases nuclear G-actin pool, thereby promoting retention of MRTFA in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334).
Protein: FLGH_CAMJD
Sequence: MKKVLFYVLPFAFFGCSATVDPQISMKPPAYVEELAPKQSNNVESAPGSLFGKGDNPLFSDKKAMNVNDLVTVIIQESTTQSTQANKATSRTNTSNLDGGTLTGSSGVVASALDKVNAYSNIGFQTNSSNNYTGTGSQSRNESFNTTISTRVIKILSNGNYFIEGSRELLINGEKQIIQLSGVIRPYDIGQDNTIDSKYIADAKILYKTEGEVDRSTRKPWGSKVIEAIWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: RL6_HELP2
Sequence: MSRIGKRIIEIPSSVQASVEGSKLLFKNSKEKHELETHNRVKITLENNQLSFQPVGEDAQSRAYWGTYGALANNIVIGLSTGFSKTLEVNGVGYKVALGNKTLDLSLGFSHPVKYPIPAGIEMVVEKNTITIKGSDKQKVGQVAAEIRSFRPPEPYKGKGVKYSNEVIIRKAGKTAKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RIMK_AERHH
Sequence: MKIAILSREPNNYSTRRLVEVAQARGHQVEVLDTLRCYMNIASHNPSIHYEGRELESYDAVIPRIGASITFYGTAVLRQFEMMNTMALNSSVAISRSRDKLRAMQLLSRHGIGLPVTGYAHSTHDVPDLITMVGGAPLVVKLLEGTQGIGVVLCETQKAAESVIEAFIQTNNNILVQEYIREANGADIRCLVVNGKVVAAMRRQAQPGEFRSNLHRGGTAEAIKISPEERATAVQAAKIMGLDVAGVDILRSARGPLVLEVNSSPGLQGVEAASGKDVAGKIIEFLELKASRKHKPAE
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: MED10_CANGA
Sequence: MGSVKSSNPALEGLHEELGVMEEQIRSIIESFIELGVSVYDFPGTPEASQGMVTNLKRNVDRIFKLNQTSNDPQSALKDVNVPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRAKMHGMGMLRDSLAEKIKEQFPELKDDVENIVQRTNMKPTGQARVNSGTTNMTTTAEQSNVVNATAGDVGTNANTTESVEQNGI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GYAR_THEON
Sequence: MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEVFDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIARGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTLVNREVLNVRKPGFE
What are the official names of this protein?
Glyoxylate reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_FRATW
Sequence: MFQSLIAIDYGKARIGIASGQMITKTATPIGTVETYDGVPNWIELDKIIKRWNPSDIIIGLPLDTQNFETDITKSAKDFAKEVQQRYQRKVHLINEAYSTREARWRLEEVKSKKVSHIKVDALAACVILETWMSEN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_RHOP2
Sequence: MAADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSVAELSYEFVANMIRSTAGKEGLKFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLAMLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIEVISFFLKPVSHSVRLFANMLAGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYLNDAIHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.