PharMolix/UniProtQA huggingface dataset:
Protein: Y3623_ARATH
Sequence: MDCSICTTMPSILRPPRNTICGSCYEGARTTIALLKKLEGSKEDRHDKSNHNSTINNGSSISSSPLFSCEPQPLEKVIKWMKNMKETEEEQKKRIVFLSSFVSGFKEQLHADILLKPGDDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYAITLQELNSEQLQALLEFLYTGTLASDKLEKNVYALFIAADKYMIHYLQELCEQYMLSSLDISSVLNVLDVSDLGSSKTLKEACVGFVVRNMDDVVFSDKYEPFSQKNQHLCVEITRAFLMETRSKRRD
What is the function of this protein?
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB/POZ domain-containing protein At3g56230.
Protein: MNME_WOLWR
Sequence: MTNTNETIFALSTVFGKSGVAVIRISGNYALKALNHFHIKKEIKPRFATLVDLYDDSSQLIDNGIIIYFPAPNSFTGEDVIELQVHGSKAVIKIILEELSKVFVMAKPGEFSLRAFLNGKFDLTQIEGIADLIDAETKMQAKQAIKQISGELERLYSNWRQRLITIQSKIEAYIDFPEDIWAEKSELEKINNEVQSLVRLIQEHLNDNRRGERLREGLHIVITGEPNVGKSTLFNFLAKRDIAIVSEYAGTTRDILEAHIDIGGYPIILSDTAGIRESSDPIELEGISRAKKRSFEADLRIELFPFEQRPNINCNVVNSDTIYVLSKADDVINNHDIKINGIDLLPVSILKGIGTNKLISLIKEKAEEKFGHDRDTPVITRQRHRNHMQKALEHLQRFNIDNPIELISEDLRLAAFELGAVIGIIDVEEILSSVFSNFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_ACTSZ
Sequence: MSYPQEVDKRRTFAIISHPDAGKTTITEKVLLYGNAIQTAGSVKGKGSQAHAKSDWMEMEKQRGISITTSVMQFPYNDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTIKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVESVLKIHCAPITWPIGCGKLFKGVYHLYKDETYLYQSGQGSTIQEVRIIKGLDNPQLDAAVGADLAQQLREELELVQGASNEFDQELFIGGELTPVFFGTALGNFGVNHFLDGLTQWAPKPQARKADTRIVESAEEKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLKHVRIGKDVVISDALTFMAGDRTHAEQAYAGDIIGLHNHGTIQIGDTFTQGEDLKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLANNDLIVGAVGVLQFDVVVARLKTEYNVEAVYENVNVATARWVECADEKKFEEFKRKNEQNLALDGGDNLTYIAPTMVNLNLSQERYPDVTFFKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_THET8
Sequence: MRAVWVLGIDTSCDDTGVGLVRDGKVVVNLVASQVRLHEAFGGVVPELASREHLKALPLLVERALAEAGLRPKDLDLVAATRGPGLIGALLVGYTFAKGMAFALDRPFYAVHHLEGHIAAAWPEGLPPPFLALVASGGHTHLYEVLDLGRYRLLGATRDDAAGEAFDKVARLLGLGFPGGPEVERLAEEAEEAIPFPVPLRGQEGYDFSFSGLKTKALHLVEKGLPKAALAKGFQEAAIAHLAEVVLKAAKDTGHRVLLVAGGVAANRALQERFKEAGLEVHFPPRGLSQDNGAMIALAAWRRHQRGFPPSPLSLGATAYWPLEEA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMTK3_MOUSE
Sequence: MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPPWQPASAPPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPGPQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLERGDAVAGWGDHPALGCPHPPEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAKEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVSTEQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVPSRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLANGVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAPAPCEAALPQNGLEMAPGQLGPAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGRALGGVGTAPAGGPASAVDAKAGWVDNSRPLPPPPQPLGAQQRRPEPVPLKARPEVAQEEEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEEAAGSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN
What is the function of this protein?
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.  May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity).  Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).
What are the official names of this protein?
Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.
Protein: PDC2_PEA
Sequence: PVYISIGCNLPAIPHPTFSRDPVPFSLAPKLSNQMGLEAAVEAAAEFLNKAVKPVLVGGPKLRVAKASDAFVELADASGYALAVMPSAKGMVPEHHPHFIGTYWGAVSTAFCAEIVESADAYLFAGPIFNDYSSVGYSLLLKKEKAIIVMPDRVVIANGPAFGCVLMNDFLKALAKRLKHNNVAYENYHRIFVPDGTPLKSASKEPLRVNVMFQHIQKMLSSETAVIAETGDSWFNCQKLKLPEGCGYEFQMQYGSIGWSVGATLGYAQAVPEKRVIACIGDGSFQVTAQDVSTMLRCGQKTIIFLINNGGYTIEVEIHDGPYNVIKNWNYTGLVDAIHNGEGKCWTTKVFCEEELVEAIAKATGPKKDSLCFIEVIVHKDDTSKELLEWGSRVSAANSRPPNPQ
What are the official names of this protein?
Pyruvate decarboxylase 2, PDC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: HIS5_CHLTE
Sequence: MVFIADYGAGNLRSVHKAFDYLGIEAVVSDKASEMSRYDKVLIPGVGAFGPAMEALNRQGFDEAIREHIDKGRSVLGICLGMQLFLSESEEMGAYKGLDIVPGKVLRFTSSTDKIPQIGWNSVDYCKDSVLFRNVPDQSYFYFVHSYYCAPDEPESVAATTFFAGKKFCSAIEKNGIFAVQFHPEKSSEAGLQVLKNFAEF
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_MYCA9
Sequence: MTDLIRQDAAALAALIHSGEVSSVEVTRAHLDQIASTDETYRAFLHVAGEQALAAAKDVDDAIAAGSVPSGLAGVPLALKDVFTTRDMPTTCGSKILENWVPPYDATVTARLRGAGIPILGKTNMDEFAMGSSTENSAYGPTRNPWDVERVPGGSGGGSAAALAAFQAPLAIGTDTGGSIRQPAALTATVGVKPTYGTVSRFGLVACASSLDQGGPCARTVLDTALLHQVIAGHDPRDSTSVDEPVPDVVAAARAGASGDLKGVRVGVVTQLRGDGYQPGVMASFDAAVEQLTALGADVVEVSCPHFEYALPAYYLILPSEVSSNLARFDAMRYGMRVGDDGTHSAEEVMALTRAAGFGPEVKRRIMIGTYALSAGYYDAYYGRAQKVRTLIKRDLERAYEQVDVLVTPATPTTAFRLGEKVDDPLAMYQFDLCTLPLNLAGHCGMSVPSGLSADDGLPVGLQIMAPALADDRLYRVGAAYETARGALPAAL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: MURB_FRATT
Sequence: MSEYISLEQYNTYRIKSFAKYVYFPTNNQELLDIVNNHNKLFFLGNGSNVIFSKEYYDDVAFVIFTKKFNSFNIIDNYASVQAGVLLQDLAFATYNASLSGIETFYDVPASVGGALIMNAGAYGDEIYTCVKSVTILDLNTKQIKKYLKKDIEYGYRYSIFKYMKDICILSAEFEFEYKSKQEIKAKLDDIYSRRLSNLPQKPTAGSVFKRPQANMPVGIMVEQLGLKGKQIGDAQISPKHGGIIVNNGNATGQNILDLIEFIKQQILEHYNIELHEEQIVI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDNF_HUMAN
Sequence: MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRKFC
What is the function of this protein?
Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645).  Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645).  Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645).  May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645).  Also regulates extracellular matrix assembly and cell adhesiveness (By similarity).  Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
What are the official names of this protein?
Protein NDNF, Neuron-derived neurotrophic factor.
What are the subcellular locations of this protein?
Secreted.
Protein: FADI_IDILO
Sequence: MTAAQRLLTVNGERIAFVAGIRTPFAKQATDFHGIPAVDLGKMVVQELVNKTGIDGDWVEQLVFGQVVQMPEAPNIAREIVLGTSLPVGTDAYSVSRACATSFQSAVNIAEAMVAGHIRGGIAGGADSSSVLPIGVSKRMARALVDLNKAKTLGQRFSILKRLGFKDLLPVPPAVAEYSTGLSMGQTAEQMAKTHNISREDQDELTVRSHQKAHAAWEAGWLSDEVMTAYPEPYKKHLSRDNNIRGDSQIEKLAKLKPVFDRKHGSVTAANSTPLTDGASAVMMMTESRAKELGLPVLGYLRSYAFAALQVEEDMLMGPSYSTPVALDRAGMSLNDLDLIDMHEAFAAQTLANMKMFASDKFAQEKLGRDKAIGEIDMDKFNVLGGSIAYGHPFAATGTRMITQTLNELRRRGGGVGLTTACAAGGLGAAMIVETE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARFM_ARATH
Sequence: MENNGEMNAQPELSVDITKTYMYEKLWNICAGPLCVLPKPGEKVYYFPQGHIELIENSTRDELDHIRPIFDLPSKLRCRVVAIDRKVDKNTDEVYAQISLMPDTTEVMTHNTTMDTRRPIVYFFSKILTASDVSLSGGLIIPKQYAIECFPPLDMSQPISTQNLVAKDLYGQEWSFKHVFRGTPQRHMFTSGGGWSVFATTKRLIVGDIFVLLRGENGELRFGIRRAKHQQGHIPSSVISANCMQHGVIASVVNAFKTKCMFNVVYKPSSSQFVISYDKFVDAMNNNYIVGSRFRMQFEGKDFSEKRYDGTIIGVNDMSPHWKDSEWRSLKVQWDELSPFLRPNQVSPWDIEHLIPSSDISQSSLKKKKHWLQLNEIGATLSNLWTCQEIGQRSMNSPISVPEFSYPNAIEDSKFLSGLLLNHSLLAIPNENYNSDQMIQPRKEDITTEATTSCLLFGVDLTKVSKSKDSICPIESCKKSLPQDKKFDQTQPLRSPKEVQSTEFNFTRSRIKVHMQGVAISRAVDLTAMHGYNQLIQKLEELFDLKDELRTRNQWEIVFTNNEGAEMLVGDDPWPEFCNMAKRIFICSKEEIKKMKLKNKFFQPESKALTSSDVPPNVTDN
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Could act as transcriptional activator or repressor.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin response factor 13.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GNTX_ECOL6
Sequence: MLTVPGLCWLCRMPLALGHWGICSVCSRAARTDKTLCPQCGLPATHSHLPCGRCLQKPPPWQRLVTVADYAPPLSPLIHQLKFSRRSEIASALSRLLLLEVLHARRTTGLQLPDRIISVPLWQRRHWRRGFNQSDLLCQPLSRWLHCRWDSEAVTRTRATATQHFLSARLRKRNLKNAFRLELPVQGRHMVIVDDVVTTGSTVAEIAQLLLRNGAATVQVWCLCRTL
What is the function of this protein?
Could be involved in gluconate metabolism.
What are the official names of this protein?
DNA utilization protein YhgH, Protein GntX.
What is the protein family that this protein belongs to?
Belongs to the ComF/GntX family.
Protein: Y995_HAES1
Sequence: MTEKFKKLDPDTAIDIAYDIFLEMAGENLDPTDILLFNLQFEDHGGVEFVETADDWEQEIGVLIDPDEYAEVWVGLVNEQDEMDDIFAKFLISHKEEDREYHVVWKK
What are the official names of this protein?
UPF0263 protein HS_0995.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: PDE6A_CANLF
Sequence: MGEVTAEQVEKFLDSNIIFAKQYYNLRYRAKVISDMLGAKEAAVDFSNYHSLSSVEESEIIFDLLRDFQENLQAERCIFNVMKKLCFLLQADRMSLFMYRVRNGIAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVAHSKKIANVVNTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAVIMAVNKVDEPHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLAQFLGWSVLNPDTYESMNRLENRKDIFQDMVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQGELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDTKMKALEEEKQKQQTAKQGAAGDQPGGNPSPAGGAPASKSCCIQ
What is the function of this protein?
Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP.  This protein participates in processes of transmission and amplification of the visual signal.
What are the official names of this protein?
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium, photoreceptor outer segment.
Protein: CCL2_RAT
Sequence: MQVSVTLLGLLFTVAACSIHVLSQPDAVNAPLTCCYSFTGKMIPMSRLENYKRITSSRCPKEAVVFVTKLKREICADPNKEWVQKYIRKLDQNQVRSETTVFYKIASTLRTSAPLNVNLTHKSEANASTLFSTTTSSTSVEVTSMTEN
What is the function of this protein?
Acts as a ligand for C-C chemokine receptor CCR2 (By similarity).  Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity).  Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity).  Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).  Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
What are the official names of this protein?
C-C motif chemokine 2, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Small-inducible cytokine A2.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: YCF4_DRANE
Sequence: MSWRSESIWIEFITGSRKTSNFCWAFILFLGSLGFLLVGTSSYLGRNFISLFASQQIIFFPQGIVMSFYGIAGLFISCYLWCTILWNVGSGYDLFDRKEGIVRIFRWGFPGKSRRIFLRFLMKDIQSIRIEVKEGVSARRVLYMEIRGQGAIPLIRTDENFTTREIEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SIGS_STAAW
Sequence: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNFYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKLLNQRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKMSVKRKCQHNFN
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigS.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: HIS5_CERS4
Sequence: MLTVLVDYDSGNLHSAEKAFQRMATETGAGQVLVSDRPEDVARADRIVLPGDGAFPACRRALGSYGGLSEAIEEAVTRRARPFLGICIGMQMMATRGLEHEETPGFGWIAGEVVRIAPSDPHLKVPHMGWNDLTVDHPHPVLTGIETGDHAYFVHSYHFQVAHDAERLAHADYGADITAIVGRDTMVGTQFHPEKSQKTGLRLIANFLTWKP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN115_HUMAN
Sequence: MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGGSRIDNTTTTHFAELWGHLDHTMFFQDFRPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASASNRFSNDSQLHDRWTF
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes.  Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF115, RING finger protein 115, RING-type E3 ubiquitin transferase RNF115, Rab7-interacting RING finger protein, Rabring 7, Zinc finger protein 364.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes.
Protein: KKX11_CHEFU
Sequence: GHACYRNCWREGNDEETCKERCG
What is the function of this protein?
Shows weak blocking activity on voltage-gated potassium channels Kv10. 1/KCNH1/EAG1 (IC(50)=26 uM), Kv1. 2/KCNA2 (Kd=150 uM), Kv1. 3/KCNA3 (Kd=40 uM), Kv1. 6/KCNA3 (16. 6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329).  The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709).  Also shows a weak inhibitory activity on the plant pathogen F. culmorum growth (IC(50)=18. 8-37. 7 uM) (PubMed:27578329).
What are the official names of this protein?
Potassium channel toxin kappa-KTx 1.2, Kappa-hefutoxin 2, Kappa-HfTx2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PVK3_ELLSS
Sequence: GSSGMIPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-3, EllSp-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF1_CAMJJ
Sequence: MLASKLDPFLKRFEELNSLLSSSDILNDISKMTTLSKEQKNLEPIVLKAKEYLKTLDNIEENKALLNDPELGELAKEELKTLEELKPKLEEEIKILLLPKDPNDERNIFLEIRAGTGGDEASLFVGDLVKAYARYAENRGYKLEIVSSSEGSVGGFKEIIMLVKGTGAYSRLKYEGGTHRVQRVPQTESQGRVHTSAITVAVMPEVDDIEIEINPNDLKVDVMRSSGHGGQSVNTTDSAVRITHIPTGIVVVNQDGKSQHKNKESAMKVLKARLYEMQESERLAKESEARKSQVGSGDRSERIRTYNFPQNRISDHRINLTLYRLDAIMQDGLFDEIIEPLITHHQAQALQEQNL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUI1_PICTO
Sequence: MKDKNFTGIPKELQPWEGFDRNNEVVKISVDKRRYGKVVTLIEGIDPKVEDINEIAKSLKKKVASGGTVKDGKIIELQGDHRETARAQLESMGFKVQMV
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: UCRIA_CHLRE
Sequence: MAMLSSRRVAAPAKASAIRRSRVMPVVRAAAASSEVPDMNKRNIMNLILAGGAGLPITTLALGYGAFFVPPSSGGGGGGQAAKDALGNDIKAGEWLKTHLAGDRSLSQGLKGDPTYLIVTADSTIEKYGLNAVCTHLGCVVPWVAAENKFKCPCHGSQYNAEGKVVRGPAPLSLALAHCDVAESGLVTFSTWTETDFRTGLEPWWA
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, chloroplastic, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, Rieske iron-sulfur protein, ISP, RISP.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: PDXT_BACC1
Sequence: MVKIGVLGLQGAVREHVKSVEASGAEAVVVKRIEQLEEIDGLILPGGESTTMRRLIDKYAFMEPLRTFAKSGKPMFGTCAGMILLAKTLIGYDEAHIGAMDITVERNAFGRQKDSFEAALSIKGVGEDFVGVFIRAPYVVNVADNVEVLSTHGDRMVAVRQGPFLAASFHPELTDDHRVTAYFVEMVKEAKMKKVV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.