PharMolix/UniProtQA huggingface dataset:
Protein: SSPA_DICDI
Sequence: MEKIKKQNNIGSYSSDKDGEYKKFRFSKTSIRGFLLKEYEREVPIIVKIQSYRNKFLDFYFKMASILGEEVFFILALPISTWCVATQLGVELCVVLALTIGGGNILKNTFTLPRPPPNIVWTNTAHQKDHGLPSTHTASAFGLTFYFLIYTYFLFPTIGESFNISLLSMFFIVLFWSTSVMFSRLYNGHHTPMDVIAGLIVAITSILATTYQLRYFIEGMVLSETFLFGPMLYIAILSAILFFHPQANTGPTPAYPETGLVCGASLGSLISLWLHAQHPCPLMNQELLLLEANYDSIVSTIHSIPLLLHGSRILIGLVLVGIAKVFSKKFFFFAYDLVIRANTNNEQSQPITTVSFDPNKKIIVTPTIEAFSKLFVYTCVSFTIVSMPYLFYYLNIQTSADVTRYY
What is the function of this protein?
Has enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P.  Regulates intracellular and extracellular S1P levels (By similarity).
What are the official names of this protein?
Probable sphingosine-1-phosphate phosphatase, SPPase.
What is the protein family that this protein belongs to?
Belongs to the type 2 lipid phosphate phosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DNAA_MYCS2
Sequence: MTADPDPPFVAVWNSVVAELNGDVNGDRQGDPSLPVLTPQQRAWLKLVKPLVIAEGFALLSVPTPFVQNEIERHLREPIVTALSRKLGQRVELGVRIATPTDEPEDAPDSFADSPAPASVPAGPADADEIDDDRDARVNAQESWPKYFSRPEPDTSSDDSNAVNLNRRYTFDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKASFKRSYRDIDILLVDDIQFIEGKEGIQEEFFHTFNTLHNSNKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTRIDRSLAEVVLRDLIADATTMQISTAAIMAVTAEYFETTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFDHVKELTTRIRQRAKR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_BURO0
Sequence: MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPRNFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAQVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMADTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIYTSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: POLS_EEVVT
Sequence: MFPFQPMYPMQPMPYRNPFAAPRRPWFPRTDPFLAMQVQELTRSMANLTFKQRRDAPPEGPSAKKPKKEASQKQKGGGQGKKKKNQGKKKAKTGPPNPKAQNGNKKKTNKKPGKRQRMVMKLESDKTFPIMLEGKINGYACVVGGKLFRPMHVEGKIDNDVLAALKTKKASKYDLEYADVPQNMRADTFKYTHEKPQGYYSWHHGAVQYENGRFTVPKGVGAKGDSGRPILDNQGRVVAIVLGGVNEGSRTALSVVMWNEKGVTVKYTPENCEQWSLVTTMCLLANVTFPCAQPPICYDRKPAETLAMLSVNVDNPGYDELLEAAVKCPGRKRRSTEELFKEYKLTRPYMARCIRCAVGSCHSPIAIEAVKSDGHDGYVRLQTSSQYGLDSSGNLKGRTMRYDMHGTIKEIPLHQVSLHTSRPCHIVDGHGYFLLARCPAGDSITMEFKKDSVTHSCSVPYEVKFNPVGRELYTHPPEHGVEQACQVYAHDAQNRGAYVEMHLPGSEVDSSLVSLSGSSVTVTPPVGTSALVECECGGTKISETINKTKQFSQCTKKEQCRAYRLQNDKWVYNSDKLPKAAGATLKGKLHVPFLLADGKCTVPLAPEPMITFGFRSVSLKLHPKNPTYLTTRQLADEPHYTHELISEPAVRNFTVTEKGWEFVWGNHPPKRFWAQETAPGNPHGLPHEVITHYYHRYPMSTILGLSICAAIATVSVAASTWLFCRSRVACLTPYRLTPNARIPFCLAVLCCARTARAETTWESLDHLWNNNQQMFWIQLLIPLAALIVVTRLLRCVCCVVPFLVMAGAAAGAYEHATTMPSQAGISYNTIVNRAGYAPLPISITPTKIKLIPTVNLEYVTCHYKTGMDSPAIKCCGSQECTPTYRPDEQCKVFTGVYPFMWGGAYCFCDTENTQVSKAYVMKSDDCLADHAEAYKAHTASVQAFLNITVGEHSIVTTVYVNGETPVNFNGVKLTAGPLSTAWTPFDRKIVQYAGEIYNYDFPEYGAGQPGAFGDIQSRTVSSSDLYANTNLVLQRPKAGAIHVPYTQAPSGFEQWKKDKAPSLKFTAPFGCEIYTNPIRAENCAVGSIPLAFDIPDALFTRVSETPTLSAAECTLNECVYSSDFGGIATVKYSASKSGKCAVHVPSGTATLKEAAVELTEQGSATIHFSTANIHPEFRLQICTSYVTCKGDCHPPKDHIVTHPQYHAQTFTAAVSKTAWTWLTSLLGGSAVIIIIGLVLATIVAMYVLTNQKHN
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to cell receptor LDLRAD3 and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits (PubMed:34646020, PubMed:34646021).  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group (By similarity).
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: CHRC1_MOUSE
Sequence: MADAAVGKEKCGDQRLVSLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQYLATCSYRHGSGKAKKALTYSDLASTAEDSETLQFLADILPKKILASKYLKMLKEKREEEEDNEDDGSDLGEALA
What is the function of this protein?
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.  Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).
What are the official names of this protein?
Chromatin accessibility complex protein 1, CHRAC-1, DNA polymerase epsilon subunit p15, NF-YC-like protein, YC-like protein 1, YCL1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL35_TROWT
Sequence: MVPKQKTHSGAKKRFKLTGSGSVSRARAGMRHNFEHRSSRVTRRLTGRQFVSDADSKLARKLLGK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ISCS_CLOBJ
Sequence: MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWALKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTEDTAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVNFSFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLDA1_SPUBR
Sequence: MAKTLLHGTLHVTIFEVDHLKAGSVVVFSESLRRTLRKPLVLAKGTPKIYASIDLDKARVGRTRMIENEPNNPKWNESFHIYCGHPSTNVIFTVKDDNPIGATLIGRAYLPVHELLEGEEVDKWVEILDEDKNPISEGSKIHVKLQYFDITQDRNWAHGIRSSKFPGVPYTFFSQRPGCRISLYQDAHVPDNFVPKIPLSGGKFYEPHRCWEDVFDAITNAKHFIYITGWSVYTEFALIRDTRRPKPGGDIMLGELLKKKADEGVRVLMLVWDDRTSVGLLKKDGLMATHDQETEEYFRDSNVHCVLCLRNPDDGGGIIQGLTISTIFTHHQKIVVVDSEMPTSGSENRRVVSFVGGIDLCDGRYDTPFHSLFRTLDTAHHDDFHQPNFEGAAITKGGPREPWHDIHSRLEGPVAWDVLFNFEQRWRKQGGKDILLNLRELQDVIIPPSPVTFPDDDETWNVQLFRSIDEGAAFFFPQTPEEAAKAGLVSGKENIIVRSIQDAYIHAIRGPKISFILKISIFLEALLAGIQRILKMRTSVLCILIPKELSLKIVSKIEAGKRFTVYVVLPMWPEGIPESGSVQAILDWQRRTMEMMYKDIIQALQANGIEEDPRNYLTFFCLGNREVKRDGEYEPSEKPDPDTDYSRAQESRRFMIYVHAKMMIVDDEYIIIGSANINQRSMDGAKDSEIAMGAYQPHHLATREPARGQIHGFRMSLWYEHLGMLDDTLALPESVDCVQKVNTVADKYWDLYSSETLENDLPGHLLRYPIAVASEGNVTELPGTEFFPDTKARVLGAKSDFLPPILTT
What is the function of this protein?
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.  Plays an important role in various cellular processes.
What are the official names of this protein?
Phospholipase D alpha 1, PLD alpha 1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D 1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. C2-PLD subfamily.
Protein: GET1_AJECH
Sequence: MPSLLITALFLNVIIYVINTVGAATVDGLLWLLYIQLPTGTSQIAREQRHMKREVVQLKHEMSSTSSQDEFAKWAKLRRRHDKALEAYEAKNNELTQSKSTFDITIKIARWAATSGLMLFLQFWYSKTPIFTLPPGWIPWQVQWVLSFPRAPMGTVSIQIWSGACATVVALVGDAMKASLAYVSKPKIDRIKLGATMEGKEGKKRQ
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein GET1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ASPD_METM6
Sequence: MLKIGVVGCGAIASLITKALMSDRLNKAEVLAFYDGNLEKAEKLAMETGADFCRSLDELVSKDLDLIVECASVTAVEDTVIKSLNNGKDVIIMSVGALADKDLFLKLYKLAEKLGRKIYIPSGAIAGIDAVKSGSLGKISDVTLTTTKPVHGLKSALEEQGLNTDEIKEPKVVFEGTVFEAISKFPQNINVSVVLSLASRYPAKVKIIADPNAVVNRHEILVKGSIGTIKTCVENNPCRDNPKTSALAAYSVIRLIKDLSEPVRIGT
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: RL11_THEM4
Sequence: MAKKVVAQVRLQLEAGKATPAPPVGPALGQRGVNLMEFCKKFNAATADKAGMIIPVIITVYEDRSFTFITKTPPASFLLKKAAKLNSGSQEPKRKIVGKVTREQIKEIAEIKKEDLNANDIEAAMKIIEGTAKSMGIEVVD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: NHAA_RHILO
Sequence: MQDLKQRPVSVFREFLDSEAAGGIILMVAAALALIVANSPLAETYFSVLHAYLGPLSVSHWVNDGLMAVFFLLVGLEIKREMLDGQLSTWPRRVLPGIAAAGGMLVPALVYVFINRNNSAALSGWAIPTATDIAFALGVLSLLGSRVPASLKVFLTALAIIDDLGAVIIIAIFYTSGLSLAYLGAAFAVIAALVVLNRMRVMTLLPYLVLGAILWVLVLKSGVHATLAGVALALTIPLERSAGVGHDLDHSPLHRLEHGLHKIVPFFVIPIFGFANAGVSLAGLSLGALIEPLTLGVAAGLVVGKLVGVFGSSALAIRLGLADLPAHTGWSHMIGISLLCGIGFTMSLFIGLLAFASDVALQDAVKVGILAGSFVAAILGAAVLLMAPAAGVAEEETE
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COPG2_XENTR
Sequence: MIKKFDKKDEESGIGSNPFQHLEKSAVLQEARLFNETPINPRRCLHILTKILYLLNQGEHFGTMEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMANISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDATMLQGIERYMKQAIVDKVSSVSSSALVSSLHMTKISYDVVKRWINEAQEAASSDNIMVQYHALGLLYNLRKNDRLAVSKMLNKFTKSGLKSPFAYCMLIRIASRLLEESEEGHNSPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISTFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIIEENPDSKESGLAHLCEFIEDCEHTVLATKILHLLGREGPKTPTPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNEPLLPSVLVLLQRCMMDSDDEVRDRATFYFNVLNQNQLALNTAYIFNGLTVSVFGMEKALHQYTLEPSEKPFDMKTVPLATVPFLEQKTDLAPIATKQPEKMVPVRQDIFQDQLAAIPEFKNLGPLFKSSEPVQLTEAETEYFVRCIKHVFPNHIVFQFDCTNTLNDQLLEKVTVQMEPSEAYEVVHYVPAPSLPYNQPGISYTLVRLPDDDPTAVSCTFSCTMKFVVRDCDPQTGVPDDEGYSDEYVLEDLEVTLSDHIQKILKPNFGAAWEEIGDTYEKEETFALTTTKSLEEAVNNIIKFLGMQPCERSDKVPENKNSHVLYLSGVYRGGHDVLVRSRLALADGVTMQVTVRSQDETPANVILVSVG
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit gamma-2, Gamma-2-coat protein, Gamma-2-COP.
What is the protein family that this protein belongs to?
Belongs to the COPG family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NCB5R_NEOFI
Sequence: MSALSSENINGVYIPSALLIFGTFIVKKEFVPYAVALTAILAGLKLFTGGSKPRKVLNPTEFQEFVLKEKTDISHNVCIYRFALPRPADILGLPIGQHISLAATIEGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLKIGDTMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMLQIIKAVIRNRPRNGGNDTTKLDLIFANVNPDDILLKEELDKLAAEDPDFNIYYVLNNPPQGWTGGVGFVTPEMIKEHLPAPASDVKILLCGPPPMISAMKKATESLGYTKARPVSKLEDQVFCF
What is the function of this protein?
NADH-dependent reductase for dph3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1.  By reducing dph3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: CLP1L_PONAB
Sequence: MWSGRSSFTSLVVGVFVVYVVHTCWVMYGIVYTRPCSGDANCIQPYLARRPKLQLSVYTTTRSHLGAENNIDLVLNVEDFDVESKFERTVNVSVPKKTRNNGTLYAYIFLHHAGVLPWHDGKQVHLVSPLTTYMVPKPEEINLLTGESDTQQIEAEKKPTSALDEPVSHWRPRLALNVMADNFVFDGSSLPADVHRYMKMIQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKVSLGRLRFWIHMQDAVYSLQQFGFSEKDADEVKGIFVDTNLYFLALTFFVAAFHLLFDFLAFKNDISFWKKKKSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLVPAGVGAAIELWKVKKALKMTILWRGLMPEFELGTYSESERKTEEYDTQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVNGVYAFGFLFMLPQLFVNYKLKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVFLVYLYQRWLYPVDKRRVNEFGESYEEKAARAPHTD
What is the function of this protein?
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI).  GPI is a lipid glycoconjugate involved in post-translational modification of proteins.  Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
What are the official names of this protein?
Lipid scramblase CLPTM1L, Cisplatin resistance-related protein 9, CRR9p, Cleft lip and palate transmembrane protein 1-like protein, CLPTM1-like protein.
What is the protein family that this protein belongs to?
Belongs to the CLPTM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DPO3_OCEIH
Sequence: MDISKKEKLKLLLEQIRMPDNEIEAHFSNSYLDKVEVHKADKKWHFYINIDHVLPFQTYQLFHHSLKESFASIAEVSLTLSAENRHCPEGDIQIYWKHFIAQTSLSPAYRDLVLDQAPEVSNNKIMLTARNEAEASALKKRLEAKFHDFCLSIGSLPYTLEVEVKTNTEAMQEFRDKKALEDQQLVMKTVQEKEKRDKDKSVPDQQPLAIGYKIQDEPITMDQIIDEERRITVQGYVFDAEVRELRSGRSLLIIKATDYTDSIQIKMFSKGDEDAAKFASVKKGMWVKARGSIQTDMYTNELAMMAKDIHEIHVSQRMDDASEDKKRVELHTHTTMSQMDAVVSPEALVEQAAKWGHKAIAITDHAGVQGFPDAHNAGKKHGVKVLYGVEANLVDDGVPIAYNEADRNLYEDTFVVFDVETTGLSAVYDTIIELAAVKIKGGEIVDRFESFANPHHALSQTTIDLTGITDDMVNDAPEVADVLKDFHTWMGNDILVAHNASFDMGFLNQGFQRIDYEKASNPVVDTLELARFLLPELRNHRLNTLCKHLDIELTQHHRAIYDAEATGYLLWKLVQRLVEKEISNHLELNNHMGENNAYQRSRPYHCTLIAQTEEGLKNLYKLVSRAHIDFFYRVPRLPRSVLQKHREGILVGTACDKGEVFETMMQKSEEEAEQVADFYDYIEVQPPENYTHLIEKDLVQNESQILDILRKLVNLGDKMKKTVVATGNVHYLHEHDKQYRQILIGSQAGNPLSRHKLPDTPFRTTTEMINCFHFLGEKKANEIVVDNTQKLTDSIEEISPVKDGLFTPNIEGAEQEMRDLCYNKAKEVYGEPVPQIVVDRLEKELESIIGNGFAVIYLISQKLVKKSLDDGYLVGSRGSVGSSFVATMTEITEVNPLVPHYVCKHCHHHEFFTDGSVASGFDLPDKDCPGCGKGLTKDGQDIPFETFLGFKGDKVPDIDLNFSGDYQPRAHNYTKELFGIDNVYRAGTIGTVAEKTAYGYVKGYASDNQFVYKNAEVDRLVQGCTGVKRTTGQHPGGIIVVPSDKEIYDFTPIQFPADDRNSEWRTTHFDFHSIHDNLLKLDILGHDDPTVIRMLQDLSGMDPKNIPTDDEEVMKIFSGTESLGVTPEQINCKTGTLGVPEFGTKFVRQMLEDTKPKTFAELLIISGLSHGTDVWLGNAQELINDGICQLPDVIGCRDDIMVYLMHKGLDPSMAFTIMEFVRKGKGLKDEWIDEMKKHAVPDWYIESCKKIKYMFPKAHAAAYVLMAVRIAYFKVHHPILFYAAYFTVRADDFELDTMIKGSDAIRKRIEEITVKGNDASPKEKNLLTVLEISLEMCERGFSFKKVDLYQSSATDFIVEGDSLLPPFNAVDGLGTNAALNIVKAREEGEFLSKEDLRERSKISKTVLEYLDNHGCLEGMEDKNQLSLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_ACTSZ
Sequence: MNNNIIHYTLDTLGLRCPEPVMLVRKQIRHMQNGEMLLVIADDPATTRDIPGFCQFMEHTLVRAEMERPPFRYWVKKGK
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_BURP6
Sequence: MDIKRTVLWVIFFMSAVMLFDNWQRSHGRPSMFFPNVTQTNTASNATNGNGASGANAAAAANALPAAATGAAPATTAPAAQAQLVRFSTDVYNGEIDTRGGTLAKLTLTKAGDGKQPDLSVTLFDHTANHTYLARTGLLGGDFPNHNDVYAQVAGPTSLAADQNTLKLSFESPVKGGVKVVKTYTFTRGSYVIGVDTKIENVGAAPVTPSVYMELVRDNSSVETPMFSHTFLGPAVYTDQKHFQKITFGDIDKNKADYVTSADNGWIAMVQHYFASAWIPQSGAKRDIYVEKIDPTLYRVGVKQPVAAIAPGQSADVSARLFAGPEEERMLEGIAPGLELVKDYGWVTIIAKPLFWLLEKIHGFVGNWGWAIVLLTLLIKAVFFPLSAASYKSMARMKEITPRMQALRERFKSDPQKMNAALMELYKTEKVNPFGGCLPVVIQIPVFISLYWVLLASVEMRGAPWVLWIHDLSQRDPYFILPVLMAVSMFVQTKLNPTPPDPVQAKMMMFMPIAFSVMFFFFPAGLVLYYVVNNVLSIAQQYYITRTLGGAAAKKKAS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCLC_PSEPU
Sequence: MLSRLSIRLVVWLGCVGLSLLAVTASAADYPSKPIRWIVPFPPGGAIDMVSRVLAQRVSETLGQPVTVENRPGSGGIIGSAEVARSPADGYTLLVNSTGLAVDKWFYPNVAYDARKAFAPVALLATIPSVLVVPADSPYKDARSLLAYAKANPGKVSFASAGMGTSIHLAAALLAAQAGVDLLHVPYKGSTPAAADLIAGRLSMMVDSITAQQSFIKSGRVRALGVTSLQPAPSLPGIPPLAQAADQPNFEVLTWFGLFVPSRTSPDIVKVLNTAMNEALKTPEVQKALADIGASAQGGTSQALGVLWDNEIDRWGQLIVHHRLNTNEL
What are the official names of this protein?
UPF0065 protein in clcB-clcD intergenic region.
What is the protein family that this protein belongs to?
Belongs to the UPF0065 (bug) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YJJB_YERE8
Sequence: MVMSLLWALLQDMVLAAIPALGFAMVFNVPMRALRYCALLGALGHGSRMLMIHFGMDIEPASLLASIMIGMIGINWSRWLLAHPKVFTVAAVIPMFPGISAYTAMISVVEISHLGYSEVLMSTMVTNFLKASFIVGSLSIGLSLPGLWLYRKRPGV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: M1249_ASFB7
Sequence: MEEVITIAQIVHRGTDILSLNNEEIEALVDEIYSTLKGSNDIKNIRLIDFLFTLKDFVNHVRAEQSKLPDLSMPMEAYIRQLLVDPDVVPIVSEKKKELRVRPSTRKEIFLINGTHLAVPAEAPIEIYGLKLRLKSFSPQCFMRMAEIGSFSPETLGYVASGANLTNFIRVFMKCVDQETWKKNGEGVVVTTKENIIQFTHQYIELYKFLRSGGHSWLINRLAEEMVHRKLDREDQGSHISNIVETEEIEPEENIKRVIFFLKELSTMYSVSPVFTSGYMPLLYDLYRAGYLEVLWNPVEQKFLQHAEQREKEQMILQQVDMKLTEVITQARQYFKIMEEKIGRVQSDAIREILTMEGKVDDPNSILQEVIKACGKQEAELITTEYLNIKKQWELQEKNACAHLKLVKQLRSGLQYAELLKVLESIRVLYKEKNNTTNWNLCKACGFKLLCPHVDMLIQLQAAEASYDTMRTKLMKFSGINKEKENNQGLIYSYFCKICGEELAHFIQEDRTADVGVIGDLNSKLRIFIWQETMKACTFIHFGKLVDVKQFANIAVNVCLPLVYSIENIKKEEDYDPLTQLYAVIYIYAYILNLIYSSQKNKEFLTITIHGMKADSSLNAYVTFLLEKMMQQYSGIINQLSEITDQWIANNFREAFKKIIHQNGLQGLSVQDDTKVLLTEILLGPMYDYAATVARIDGSIPMHKPRTPKEAEYEFKTVIGRTPAELLSQKEFYDKIYTSKYRPDFTQLARLNDIYFQEESLRVWWGGRDEEKTSTLIYLRAYELFLKYLQNAPNFNSELAEFKTYENAYGEQKALLAQQGFYNIFDPNTGRADQRTRLFEYKRLPISTLYDERGLPHKWTIYVYKAVDSSQKPAEIEVTRKDVIKKIDNHYALADLRCSVCHVLQHEVGQLNIKKVQTALKASLEFNTFYAFYESRCPKGGLHDFQDKKCVKCGLFTYIIYDHLSQPELVHDYYNNYKDQYDKEKMSIRSIQIKKDMTTPSSETQPKPPQEPWTFDYGKIIKTAKILDISPAVIEAIGAMEGRSYADIREGQGAPPPPTSMDDPRLMAVDSAVRIFLYNYNCLRHVSTFNKPPMHVERLVKHLSYEEKEDLEKVLPNVVNEYHTTFKHLRVTDPASALLYSIEFLCVSFLTLYEIKEPSWVVNIVREFALTELNTIIQSEKLLSKPGAFNFMIFGEDFVCSGEDSSMDDISAYSSPGLFGEDIIDRLDDPFSIEDVDISLDVLDNLAPQ
What is the function of this protein?
Together with the penton and the other minor capsid proteins (p17, p49), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid (PubMed:31624094).  In addition, blocks IFN-beta transactivation mediated by the cGAS-STING pathway and regulates the transcriptional activity of IFN-beta.  Mechanistically, suppresses the phosphorylation of host key adapter protein TBK1 and degrades host IRF3 in the cyltoplasm (PubMed:35853521).
What are the official names of this protein?
Minor capsid protein M1249L, pM1249L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus M1249L family.
What are the subcellular locations of this protein?
Virion.
Protein: RPR2_SCHPO
Sequence: MSTKSKDQHARVSYLYQASQLLFRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKNPSIDRVLWICKKCAFKKRFSDKSC
What is the function of this protein?
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein subunit rpr2, RNA-processing protein rpr2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.