PharMolix/UniProtQA huggingface dataset:
Protein: MED4_DANRE
Sequence: MAAAAADKSTKERLLSTLDDLEVLSRELIEMLALSRSQKLPPPGEDTLILELLIQRDKEFQELMQTALEQGRVHQEMQSLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGSISSKEIIKYAHRISASNAVCAPLNWVPGDPRRPYPTDLEMRSGMLGNMSNMSTNGVNGHLPGDALAAGRLPDVLTPQYPWQSTDVSMGILPPHHGNDFGLEPPGHNKENEDDVEAMSTDSSSSSSDSD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CADH2_OTOGA
Sequence: MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLSVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHSKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESPEIEEIVFPRQLTKHNGYLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAIITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTQAWNAVYRISGGDPAGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHSGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPGTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLAEMYGGGDD
What is the function of this protein?
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell.  Cadherins may thus contribute to the sorting of heterogeneous cell types.  Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence.  Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity).  Required for proper neurite branching.  Required for pre- and postsynaptic organization (By similarity).  CDH2 may be involved in neuronal recognition mechanism.  In hippocampal neurons, may regulate dendritic spine density.
What are the official names of this protein?
Cadherin-2, Neural cadherin, N-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (By similarity). Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes (By similarity).
Protein: PGP1A_ARATH
Sequence: MLSRSVASAVTPVSSSSLLPNSKPIFCLKTLSGYRSSSFCGGCIRKINHKPLRMTSSNITPRAMATQQLENADQLIDSVETFIFDCDGVIWKGDKLIEGVPETLDMLRAKGKRLVFVTNNSTKSRKQYGKKFETLGLNVNEEEIFASSFAAAAYLQSINFPKDKKVYVIGEEGILKELELAGFQYLGGPDDGKRQIELKPGFLMEHDHDVGAVVVGFDRYFNYYKIQYGTLCIRENPGCLFIATNRDAVTHLTDAQEWAGGGSMVGALVGSTQREPLVVGKPSTFMMDYLADKFGIQKSQICMVGDRLDTDILFGQNGGCKTLLVLSGVTSISMLESPENKIQPDFYTSKISDFLSPKAATV
What is the function of this protein?
Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction.
What are the official names of this protein?
Phosphoglycolate phosphatase 1A, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS7_SHEPW
Sequence: MPRRRVVGQRKILPDPKFNSELLAKFINVIMQDGKKSTAEKIIYKALDTASEKKGEDHLVILEAALDNVRPSVEVKSRRVGGSTYQVPCEVRPVRRNALAMRWLVEAARKRGEKSMALRLAGEMLDASENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: FGF5_BOVIN
Sequence: MSLSFLLLLFLSHLILSAWAQGEKRLAPKGQPGPAATERNPGGASSRRSSSSTATSSSSPASSSSAASRGGPGSSLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHVSTHFLPRFKQLEQPELSFTVTVPEKKKPPNPVKPKVPLSAPRRSPNTVKYRLKFRFG
What is the function of this protein?
Plays an important role in the regulation of cell proliferation and cell differentiation.  Required for normal regulation of the hair growth cycle.  Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
What are the official names of this protein?
Fibroblast growth factor 5, FGF-5.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL13_COXBN
Sequence: MATYMANAKTVSPRWLLVNAEGKTLGRLASRIAAILRGKHKAEFTPHVDAGDFVVVINVDKLKVTGNKTQDKQYHHHSGYPGGLKTINFADLQAKKPQRILELAIKGMLPKGPLGRQLYRKLKIYAGDQHPHQAQQPELIDL
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: O51B5_HUMAN
Sequence: MSSSGSSHPFLLTGFPGLEEAHHWISVFFLFMYISILFGNGTLLLLIKEDHNLHEPMYFFLAMLAATDLGLALTTMPTVLGVLWLDHREIGSAACFSQAYFIHSLSFLESGILLAMAYDRFIAICNPLRYTSVLTNTRVVKIGLGVLMRGFVSVVPPIRPLYFFLYCHSHVLSHAFCLHQDVIKLACADTTFNRLYPAVLVVFIFVLDYLIIFISYVLILKTVLSIASREERAKALITCVSHICCVLVFYVTVIGLSLIHRFGKQVPHIVHLIMSYAYFLFPPLMNPITYSVKTKQIQNAILHLFTTHRIGT
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 51B5, Odorant receptor HOR5'beta5, Olfactory receptor OR11-37.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSMC_SODGM
Sequence: MSALIPASEVILRHQDTFSDKQVVIAGDVQDLLPARLEARSVKVHTAWFHHRQTLARALGEQAVQFGLVADAALGGGCDTLIYYWPKNKPEALFQLTNLLSLLPLGCDVFVVGENRSGVRSAEPMLAAWCPLAKIDSARRCGLYHGELVQQPRFDAEAFWQSYQLEDVVIKTLPGVFSRDGLDNGSQLLLSTFDRPFQGHVADIGCGTGVLSAVLAKGAAGVQLTLSDAHAPALAASRATLAVNGLQGEVLAGDVYSAISGRFDMIISNPPFHDGMQTNLKAAETLIRGALNHLRIGGELRIVANAFLPYPDLLDAVFGNHQVLVQNGRFKVYQAIHQVKRSRDKGPKRR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_SYNY3
Sequence: MAFRPRKRFGQHWLNHEPTLQAIVAAADIQSGAPQSGSLRDRLLEIGPGMGVLTKQLLATGNPVVAVELDRDLCLKLRKKLGQRENFLLLEGDVLILDLNALLQDFPQFSPLNKVVANIPYNITSPILELLLGTIQKPRVPGFETIVLLVQKEIAERLTAQPSTKAYGALSVRMQYLARVDWIVDVPPKAFTPPPKVDSAVIRLTPYPVEQLPGDRRLLDQLLCLGFANRRKMLRNNLKGLIAPEQLTTLLEQLALPSTARAEDLSLEQWLELTNLLPTFLPPT
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA_I82A2
Sequence: TDSSWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTK
What is the function of this protein?
Implicated in endonuclease cleavage of capped RNA primers.  Displays an elongation factor activity in viral RNA synthesis.  Dispensable for viral transcription, but not replication.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
Protein: ARMC5_MOUSE
Sequence: MAAARPALTDSLSFCLAQLTAAAGEGPGGGKDPATNETPLGRALLALRTRHIKAAEGIERFRARGGLRPLLALLRRTAAAGPAPSQAASGSAPSSVASAGSTPGHAPAAESLLTPSLPMRLRKTLDLALSILANCCTEGACRAEVRRLGGILPLVTILQCVKTDSIQNRTARALGNLAMEPESCRDIHSAGAVPFLVESLTACQDSQCLQSIVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDPALTAALVRALLELSRGCSRACAEQLSLGGALGPLVSLASHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRSPGGSSSATQQPLVRAVCLLCREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVGFLYDTGALGKLQALGLVPLLARQLCGEAGEEEEEGIEAASWDFPEERTSGQAEGGSFRSLRLWLISEGYAAGPGDISPDWSPERCPMPEPSESVSPTPGQTSMSTPRTLRKPGRIPAATPEEPWGQEGPALLLLSRFSQAPDPSGALVTGPALCGLLAYVTGAPGPPNPRALRILARLTCNPACLEAFVRTYGAALLRAWLVLGVSPDDWPVPHARPVHRSQHRELGEMLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTLPFICRKPTLWRRLLLDQGGLRLLLTALTQPAPHPLFLFFAADSLSCLQGLVSPTASPVPLPALPLELDSPPPCLYEPLLGPAPAPAPDLHFVLDSGLQLPAQRAASAAASPFFRALLSGSFAEAQMDLVPLRGLSPGAAWPVLHHLHGCRGCGAALGPVPPPGQPLLGSKAEEALEAAGRFLLPALEEELEEAVGRIHLSPRGGPESVGEVFRLGRPRLAAHCARWTLEPGQCPRKRALALTGLVEAAGEEAGPLTEALLAVVMGIES
What is the function of this protein?
Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:28169274).  Negatively regulates adrenal cells survival.  Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity).
What are the official names of this protein?
Armadillo repeat-containing protein 5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBB2_WHEAT
Sequence: ATRPWKCCDRAICTKSFPPMCRCMDMVEQCAATCKKCGPATSDSSRRVCEDXY
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor II-4.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: ENO_SULIM
Sequence: MINRFSIEKVKGLEIIDSRGNPTIRVFVRTNDGVESFGDAPAGASKGTREAIEVRDENGLTVKRAVDIANYIIDPALHGIDVREQGIIDKILIDIDSTENKSKLGGNTIIATSIAALKTASKALGLEVFKYIAGPRLPKIPIPLLNIINGGLHAGNKLKIQEFIVLPIKFNTFKEAFFAAIEVYRNLKGLISERYGKIYTAVGDEGGFSPPLEETREALDLIYTSINNAGYQGKIYMGMDAAASDFYDPKKEKYIIDGKELNPNQLLEFYLDLAKEYPIVYLEDPFEENSFDMFGELQNKLNSTIVTGDDLYTTNIKYLKIGIEKRSTKGVIVKPNQVGTISETFEFTNLARRNSIKLVTSHRSGETEDNFIAEFAVGIESDFIKTGAPARGERTSKYNKLLEIENKFGLEYGGKYFYL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: IL17C_MOUSE
Sequence: MSLLLLGWLPTGMTHQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ
What is the function of this protein?
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner.  Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NFKB and MAPK pathways.  Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides.  May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model.  May also promote an inflammatory phenotype, such as skin in a psoriasis model.  Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.
What are the official names of this protein?
Interleukin-17C, Il-17c, Cytokine CX2.
What is the protein family that this protein belongs to?
Belongs to the IL-17 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RDRP_SMYEA
Sequence: MATRVASVFSSLTDVGIKAALQDEAYKRIKSNLREAEIINPYSVDARGAEALEELAIITNPHSIRLHTHAAAKSIENQMLNIVGHALPKEPVTFLFLKRGKLRYLSRGRIKDIFQNQEIEPRDVARYEHKTIVQKSLLLNTRVAYISDTLHFLRPRYIIDLFSQNVFLDVLYATVVLPVEASFKHPSQNPAIYTINYNYGGFQYLPGNHGGGAYSHEFEDLDWLKYGKFIYRWVDYRTDPISGKRVGTPKELVVTCQLVESLGANHLFIFKRGDLKTPRVRTFAKDKSVTFPDLFYPEEENANFPVDAELATKLFLYVKTLKTVTSQDVHGKLRQLLRSDELTRFSPMQLTHMVNYFMVVAHLDSCNDYSMLLGSSVWTQLTAPIQSKLRKLTEFFKGKSSFGKFCAALKWKTATYSLEVVDYVETRRDSFEPHPLDSLPDADDRDVNYDTDVSEDEADEKPAPKAPTSTPVPDTTPPASPAAPADAEYTQCWAAWDTVIRKHGFKGNQAQFDDDGNLITPIAEIKSLPKDSPRCAPELIKSLQEIARTPTLVEIDSKRSNAFGSDVKNGRIGMILKKQPNDWRLSFAAKCEHTSRKVHACVIHGAGGSGKSQRLQDWMRSLKKNSRECTVILPTAELRTDWVNKVPKQSLDTFKTWEKGLVQPPNRVVILDDYGKLPAGYPEALCANYPNIELLILTGDSRQSVHNEHNKQAATASLESNIEFWTQYCRFYVNATHRNVKRLANALGVYGERDEPLKVTCSSHVYDGWPVLAPGLLKAGNLAECGRRAFTYAGCQGLTAPRVQILLDNDTPLCSQRVMYTALSRAVNEIHFVNTGPSGDDFWTKLDCTPFLKTFLELSREIEIPEAKCQETAPAEATVKTHFPVENPNLVLEPYVEKMAEKFDRELYSKEYGYSNAIQTEDPVIQLFPHQQAKDDTLMWATIDQRLAITTKSENETEFALKKDIGDLLFINYHRAMKLPKNPIPFDKDLWQSCKNEVQKTYLSKDVGSIVNGVARQDPDFPINEIKLFLKSQWVKKVEKLGMVVKPGQTIASFAQAPVMLYGTMARYMRRMREVYQPSNIFINCEKTPADLDEWAKANWNFEGLAHSNDFTAFDQSQDGAMLQFEVIKAKFHNIPSDIINSYVELKTNAKVFLGVLKIMRLSGEGPTFDANTECSIAYHHTKYWVEPDVAQVYAGDDSAQDRTPVPRPSFNKIKDRLGLVSKPLTHRQVPGDFATFCGWIITPKGVIKDPLKLYASLQLAIRRGKSHEVALSYAHDAGLAYRLGDDLHSVLTFDEAHAHQCTVRDLVKLNKVEVLRPIWALD
What is the function of this protein?
RNA replication.  The central part of this protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA replication protein, 150 kDa protein, ORF1 protein.
What is the protein family that this protein belongs to?
Belongs to the potexvirus/carlavirus RNA replication protein family.
Protein: SPRTN_MOUSE
Sequence: MDEDLVVALRLQEEWDVQMARRAAAAREPVSLVDASWELVDPTPDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYEGRGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINQLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRQPYYGYVKRATNRAPSVHDYWWADHQKTCGGTYIKIKEPENYSKKGRGKTKADKQPASAVENKDKLCRGEAQLLIPFSGKGYVLGDASTCPSAGKLNTSYMVNEAKGLSSQDHSVSGLRLNSNAEVKCEQNCLPKKPHLVSPLPTASHQSVLSSYFPRVSVANQKAFRNVNGSPVKNGTTGDGTKRPASGGSQRKVPPSRASLRNTSKVTAPASATVTSAAGTSATISREESGSEDQFLNKRPRLEDRTALDTIKEQTQSGGDLRSSSQPTAASAPQSLSSQRRLVNCPVCQGVVVESQINEHLDRCLEGNKTNLRPRRV
What is the function of this protein?
DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:28199696, PubMed:27871365).  DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:28199696, PubMed:27871365).  Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis.  Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity).  Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs.  SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity).  Involved in recruitment of VCP/p97 to sites of DNA damage.  Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation.  Does not activate CHEK1 in response to DNA damage.  May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA.  Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity).
What are the official names of this protein?
DNA-dependent metalloprotease SPRTN, Protein with SprT-like domain at the N terminus, Spartan.
What is the protein family that this protein belongs to?
Belongs to the Spartan family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress following deubiquitination. CHEK1 stimulates recruitment to chromatin.
Protein: METAA_THESQ
Sequence: MPINVPSGLPAVKVLAKEGIFVMTEKRAIHQDIRPLEILILNLMPDKIKTEIQLLRLLGNTPLQVNVTLLYTETHKPKHTPIEHILKFYTTFSAVKDRKFDGFIITGAPVELLPFEEVDYWEELTEIMEWSRHNVYSTMFICWAAQAGLYYFYGIPKYELPQKLSGVYKHRVAKDSVLFRGHDDFFWAPHSRYTEVKKEDIDKVPELEILAESDEAGVYVVANKSERQIFVTGHPEYDRYTLRDEYYRDIGRNLKVPIPANYFPNDDPTKTPILTWWSHAHLFFSNWLNYCIYQKTPYRLEDIH
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M3K1_RAT
Sequence: MAAAAGDRASSSGFPGAAAASPEAGGGGGALQGSGAPAAGAGLLRETGSAGRERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMSNLAAELQGEGQAGSAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQAFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASGSSQPSISGDVVEAFCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEISAEFYPHIVSTDVSQAEPVEIRYKKLLSLLAFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPPLFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEVIQLGSEDTLDGQQDSSQALAPPRYPESSSLEHTAHVEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSATTEQPKPTVQTKGRPHSQCLNSSPLSPPQLMFPAISAPCSSAPSVPAGSVTDASKHRPRAFVPCKIPSASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRPPPSSNIHRAKASRPVPGSTSKLGDASKNSMTLDLNSASQCDDSFGSGSNSGSAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKANEPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
What is the function of this protein?
Component of a protein kinase signal transduction cascade (PubMed:11784851).  Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:11784851).  May phosphorylate the MAPK8/JNK1 kinase (By similarity).  Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:11784851).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: PRTT_ASPFU
Sequence: MMHIQTLRKITILDVQDKQRCLSTNQNVPDNVFQLIACWCYFPPFLSIAKIKPLIALKAGISENPVLIGCRRIKMAHCPYSEAMTRTTSVEDVKFEIPAWDNSNVDVADGSGRPESSTSGDTIRPKGRIRRSMTACNTCRKLKTRCDLDPRGHACRRCLSLRIECKLPETAERFQDNASMWSDATAAIPSIEERLISLERSMTEMTSMMRRMMDRSPSISGSSVSMLTRSGITDETASIEGSQSSSFAPRPIRLFQDLQSDFTGEANVLPADSRSLGDLFTKGIIDPKLSQKLIQLFVDHFGIWISVDNPSDIHNELRATDPLLYSTACLLASRYVPGIPLSVIHAMYLQIRHATVNVLWNKTPLKHETLQALALLALWPTAVQKETPMDSWLLSGISINHAIISFDFLNHAPSDLIVDNDMVAKLRVWNALCLTQLQSAIGNARPFHIQQRYLEHCPRLLEHPAATFEDGKIVAEIQLYLIALKLQNFSHRMRLGDFEYEEIERWKMEWAHLLKLSLWYCQLLLYRTAMRFHWESEHLISEILRNSRLILSKFLLVRFPNALAFPDQIYYIVGYAALNLCDFSPMDPLIDQVQTFLLHLSPNEDHIAYRFSYTITELKRRCATGPNPHNVVKGAFGDTRKLSMGQQIPFMNPLMDTMMGEYGGLEHLIPEVPPNSLPDMLTSVAGELQAFRTAIL
What is the function of this protein?
Transcription factor required for protein utilization and degradation.  Regulates transcription of major secreted proteases including a serine alkaline protease (alk1), a metalloprotease (mep), an aspergillopepsin (pep1), a sedolisin (sed2) and two dipeptidyl-peptidases (dppIV and dppV).  However, it is not a virulence determinant in leukopenic mice.
What are the official names of this protein?
Transcriptional activator of proteases prtT, Zn(2)-C6 zinc finger-containing protein prtT.
What is the protein family that this protein belongs to?
Belongs to the prtT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNPH_MYCUA
Sequence: MSKREDGRRDDELRPVVITRGFTENPAGSVLIEFGRTKVMCTASVTEGVSRWRKGSGLGWLTAEYAMLPSATHTRSDRESVKGRVGGRTQEISRLVGRSLRACIDLAALGENTIAVDCDVLQADGGTRTAAITGAYVALADAVNYLAAAGKLSDPRPLSCAIAAVSVGVVDGRVRVDLPYEEDSRAEVDMNVVATDTGTLVEVQGTGEGATFPRSTLDKLLDMALGACDTLFAAQCDALALPYPGVLPEGPPPSKAFGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: PHOU_AQUAE
Sequence: MKLFKELEETKEQVIKMAKLVQEAIDKATEALNKQNVELAEEVIKGDDTIDLLEVDIERRCIRMIALYQPEAGDLRMIMGIYKIVSDLERMGDEAENIAERAILLAEEPPLKPYVNINFMSEIVKEMVNDSVISFIQQDTLLAKKVIEKDDTVDELYHQLERELMTYVLEDPRNIKRAMHLSFVARHYERIADHAENVAEAAIYLSEGEIVKHQHIKEKGE
What is the function of this protein?
Plays a role in the regulation of phosphate uptake.  In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex (Probable).
What are the official names of this protein?
Phosphate-specific transport system accessory protein PhoU homolog, Pst system accessory protein PhoU homolog, PhoU-like phosphate uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the PhoU family.
What are the subcellular locations of this protein?
Cytoplasm.