PharMolix/UniProtQA huggingface dataset:
Protein: CO4A5_HUMAN
Sequence: MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGTLQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCMKRT
What is the function of this protein?
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
What are the official names of this protein?
Collagen alpha-5(IV) chain.
What is the protein family that this protein belongs to?
Belongs to the type IV collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: UBCP1_XENLA
Sequence: MTLSLIIKWGGQEFPLSALSEEDTVLDLKHSLKSLTGVLPERMKLLGLKYKGKPAENDVKLGVLRLKPNTKIMMMGTREESLEEMMAPPPDNDEVVNDFDIDEEVVEVENREENLAKISRRVKDYKVEVLNPPREGKKLLVLDVDYTLFDHRSCAETGQELMRPYLHEFLSSAYEDYDIVIWSATSMKWIEAKMKELGVTTNANYKITFMLDSAAMITVHTPRRGLVDVKPLGVIWGKYGEFYSKNNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELVKLSQYLKEIAQLDDLSELNHKHWERYLAKKQGQ
What is the function of this protein?
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity.  Recruited to the 19S regulatory particle of the 26S proteasome where it dephosphorylates 19S component psmc2 which impairs psmc2 ATPase activity and disrupts 26S proteasome assembly.  Has also been reported to stimulate the proteolytic activity of the 26S proteasome.
What are the official names of this protein?
Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with nuclear proteasomes.
Protein: VEGFA_BITGA
Sequence: MNFLLTWIHWGLAALLYFHNAKVLQAAPAQGDGERQQGEVIPFLKVYERSICRPVETMVDIFQEYPDEVEYIFKPSCVALMRCGGCCNDEALECVPTEMYNVTMEVMKLKPFQSQHIHPVSFQQHSKCECRPKKDIRNKDNHCEPCSERRKHLYKQDPLTCKCSCKAPDLRCKSKQLELNERTCRCERPRR
What is the function of this protein?
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.  Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.  Binds to heparan sulfate and heparin.
What are the official names of this protein?
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRMA_MANSM
Sequence: MAWVQIRLNSTNEKAETISDYLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMQQIVRLLRQEGHLDENTAYKIEQIEDKDWEREWMDNFHPMQFGKRLWICPSWREVPDPNAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLAGKTVIDFGCGSGILAIAALKLGAKEAIGIDIDPQAILASRNNAEQNGVADRLKLYLSEDKPANMKAEVVVANILAGPLKELYPVISELVKEKGNLGLSGILATQAESVCEAYQAKFDLDAVVEREEWCRITGKLK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLD_ASPOR
Sequence: MRFVSLAVGAALLGAAGASSISSNVGLLKANGVALGNWEAAYEKASAFVSGLTTDQKLALITGSNVESANGNFTPLYFLDGDMGLQDFYYVSAFSLSSALAMTWDRDAIYEQAKAVGSEFYNKGVQVVAGPTSQPLGRTPWGGRGVEGFGPDPYLNGLATGLTTKGYVDAGVIPGGKHFLLYEQETNRTSSFGSSGEGSPYSSNADDKTIHETYLWPFYDAVKNGAGAVMCAMTKVNGTMACENSDLLMKMLKTELGFPGMVWPDMNGQNSAKGSALGGEDYGSSSIWSTSTMESFLSNGTLSEARLNDMAIRNLIGYYYVNLDNGRQPTRQTTDVYVDVRANHSKLIRENGAKSMALLKNEGVLPLSKPHVMSIFGAHAGPIMGGPNSNVDVMGSGPTYQGHLATGSGSGMASMPYLITPYDALTNKAAQDGTVLRWVLNDTYSSGGGSSLVPSSTSSTAVEPSFENFATGSDICLVFINALAGEGADRTELYNADQDAMVNTVADNCNNTVAVVNTVGPRLLDQWIEHDNVTAVLYGSLLGQESGNSIVDLLYGDVNPSGRLVHTIAKNESDYNVGLCYTAQCNFTEGVYLDYRYFDAHNITPRYPFGHGLSYTTFHYSSLAIKAPSSITKAPKGNLTVGGPSDLWDVVGTVSARIANNGTLSGAEVPQLYLGFPDSADQPVRQLRGFDRVELSAGQEAVVTFNLRRRDISYWNLKTQQWMVAGGKYTVFVGGSSRDLRLNGTFFLWVGS
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase D, Beta-D-glucoside glucohydrolase D, Cellobiase D, Gentiobiase D.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR6_PONAB
Sequence: MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCGRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSAEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMCGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLVWSKLRASILNTWISLKQADKKIRECNL
What is the function of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
What are the official names of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PAICS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
Protein: MNMC_BURM1
Sequence: MPDRLVPATLAFRDDGTLVSPAYGDIYHSAAGAIAQANHVFVAGNGLPARWQQRRTFTIVETGFGTGCNFLATWAAWRDDPARCERLHFVSVEKHPFSREDLRRAAAHIVANTTISASVDALADAWPPLVPGLHRLEFDAGRVVLTLVFGDALERLPTLVARADAFYLDGFAPSKNADLWSIDVFRALARMADEHATFATYSSSGVVKRALDEAGFAYRKVDGFAGKRAMLVGEYAPRWRMRRHEPPRAWPNAAARRALVIGAGVAGCAVVERLAARGWNVTLIERHERIASEASGNPAGVFHPLMTRDDNVASRLTRAGFLYALARWRALEAGGHAFARSTHGMVHLAESADDFARMRDAFDALGAPSDYARLLDTDAARAYLNLPVAHGGLLFPHGGAVWPAALADAQCAAAGDRVQRLTRTEVARLERNGDEWHALDAHGRTLAQAPVVVLANAGDAVRLAGLRHVALQPVRGQLTLLPAASASPPPCPAIGDGYAVPLDDGTLLIGATFEPDDVDPAIRVAGHAENLERVRRLLPGLIGDVPALDTLRGRVAFRWVAGDRLPLIGPLADEAQAVANARALSGAKARDLPRMPGLYGAFGYGSRGLVWAALGAELIASQLDGEPWPIERELAEAVDPARFLIRALRARQVSAAD
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STPG3_MOUSE
Sequence: MNFDQKAVKFLANFYINGGKHWTRGPLSQKPLHPTQPSAAAVLWWDQELETAWDEMWHPKMKRSSSGFRLRIGAPNESTPISTGTLRELWLERRPPILMDLDVPGPAQYEVPNMSLREASPHPQYTIGRKYPVREGGGRRAWQTMWLQSESPFMQKTDFNRETKWPSPAEYTPLSQPAFPAFSFGDRHRSVVKMPESRFRPGMLRARGPCSYTPLLPTSKPSGEKRPSPNTYNILPGYRLQSTRSPAFSMSRSPAFASWVSSSGTPGPAAYYVEDCYNSRFPSSPGVVIQGVRRPKRHDTGPFCTL
What are the official names of this protein?
Protein STPG3, Sperm-tail PG-rich repeat-containing protein 3.
Protein: Y3888_SHEON
Sequence: MSGWYELSKSSNDQFKFVLKAGNGEVILTSELYTGKSGAMNGIESVQTNSPIEARYAKEVAKNDKPYFNLKAANHQIIGTSQMYSSTAARDNGIKSVMENGKTTTIKDLT
What are the official names of this protein?
UPF0339 protein SO_3888.
What is the protein family that this protein belongs to?
Belongs to the UPF0339 family. Duplicated subfamily.
Protein: SPT5_ACIAM
Sequence: MESKIRNYYAVKVTGGQEVSVGLMLEERAKTNNIPEIYSIIVPPGLKGYVIVEASGPHVVKLLIAGIRHVRGIAQGLVPKDHIVKMVSKKVTGPTIKEGDLVEVVSGPFRGMQAQVVKVTEGKGEVVLNILESAFPLQVTIPVDQVKPVKKT
What is the function of this protein?
Stimulates transcription elongation.
What are the official names of this protein?
Transcription elongation factor Spt5.
What is the protein family that this protein belongs to?
Belongs to the archaeal Spt5 family.
Protein: VATC_METBU
Sequence: MRLLQKFTRKSSLKQSGSSSNYAYVTARVRAMKSNLLPREVYPRLMNMGIDEITRFIEESQYKQDVDELARTYDGVDLFEHALNRNLAVTFTKLINISEGELNYLISEYLRKYDIWSIKTILRGKYCGASVEEINDSIVSAGQLSYPFLLSLSEKESYESIIDALSGTDYYPTLKEYDGTNLSDIENKLDKMYYTGLSTTVNNPKSNDSKLFSKFIRTEIDIKNLSTLFRLKNAGVEKDEIADLILEGGLHLSIKEIEKLLPLPFSEFVQSLEKYPYWEDISGIVKTEMDSLIELETQLTRSNIKSASSFSHVYPLSIVPIMDYILNKTNEVHNLRIILRGKAANLDEEIIRNQLVI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit C, V-ATPase subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: ILVC_SINMW
Sequence: MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEADGFKVMTVAEAAAWADLMMMATPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPKASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGNALDLALSYACGVGGGRSGIIETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAARFKGIRRVNDAHQIEEVGAKLRGMMPWIGKNKLVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ACL6B_BOVIN
Sequence: MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth.  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.  ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.  Essential for neuronal maturation and dendrite development (By similarity).
What are the official names of this protein?
Actin-like protein 6B, Actin-related protein Baf53b, ArpNalpha, BRG1-associated factor 53B, BAF53B.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRR_LEUCK
Sequence: MTNKEVLDNASLQRALTRITYEIIERNKGGQDLVLVGIKTRGEFLAHRIANRLEQLEGVKIPVMAIDITNFRDDVLNHDDSLGLNDEEKTNIADKNIVLIDDVLFTGRTIRAALDALIHIGRPNTIALAVLVDRGHRELPIRADFVGKNIPTAQNEKIKVLVQEIDGRDAVEIVH
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: HSP71_ORYLA
Sequence: MSAAKSVSIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPSNTVFDAKRLIGRRFDEPVVQADMKHWPFKVVSEGGKPKIQVDYKGENKTFFPEEISSMVLVKMKEIAEAYLGHKVSNAVITVPAYFNDSQRQATKDAGVIAGLNVQRIINEPTAAAIAYGLDKGKSGERNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFKRKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTSVTRARFEELCSDLFRGTLEPVEKALRDAKMDKGQIHDVVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAAVQAAILSGDTSGNVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQVFSTYADNQPGVLIQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGNENKITITNDKGRLSKEDIERMVQEAEKYKAEDEQQRDKIAAKNSLESLAFNLKSSAQDDSLKDKISQEDRKRVVEKCDETIAWLENNQLADKDEFQHKQKELEKVCNPIISKLYQGGMPSGSCREQARADSQGPTIEEVD
What are the official names of this protein?
Heat shock 70 kDa protein 1, HSP70-1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TUB2_LOPOL
Sequence: MARLMMTVGCLIFIVVLLDMMVPVSNTCPGYFGECGDGPEEGECCGMYNYCCKGRCLMLASCQKRRDAGRLLRSLKKLKLTTH
What is the function of this protein?
Acts as a neurotoxin by inhibiting voltage-gated potassium channels (Kv).
What are the official names of this protein?
Turripeptide Lol11.2, OL67.
What is the protein family that this protein belongs to?
Belongs to the conopeptide I2-like superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SRKA_ECOL6
Sequence: MNNSAFTFQTLHPDTIMDALFEHGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPERWTADQILEEHQFALQLVNDEVPVAAPVAFNGQTLLNHQGFYFAVFPSVGGRQFEADNIDQMEAVGRYLGRMHQTGRKQLFIHRPTIGLNEYLIEPRKLFEDATLIPSGLKAAFLKATDELIAAVTAHWREDFTVLRLHGDCHAGNILWRDGPMFVDLDDARNGPAVQDLWMLLNGDKAEQRMQLETIIEAYEEFSEFDTAEIGLIEPLRAMRLVYYLAWLMRRWADPAFPKNFPWLTGEDYWLRQTATFIEQAKVLQEPPLQLTPMY
What is the function of this protein?
A protein kinase that phosphorylates Ser and Thr residues.  Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species.  Probably involved in the extracytoplasmic stress response.
What are the official names of this protein?
Stress response kinase A, Serine/threonine-protein kinase SrkA.
What is the protein family that this protein belongs to?
Belongs to the SrkA/RdoA protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_DEHMB
Sequence: MPVTAIVGGQWGDEGKGKVVDMLAQEADYVVRFSGGDNAGHTVINPMGEFKLHIIPSGVFYPGVKCIIGNGVVINPDVFIRERNELISRGVNVSNVFISDRAHLVLPYHILLDGLEEEARGNKSLGTTRRGIGPAFVDKYARMGIRVGDLLLPEYLRERLEYVLECKNQILTKVYDAAPISLDEIYETCLKWGKELAPNIRETTHIIEEAISQDKKIIMEGAQGALLDPDFGTYPYGTSSSPLAAGGCLGIGIGPASVSATLGVFKAYSTRVGGGPMPTELLDKTGDTIRNEAHEYGTTTGRPRRIGWFDAVAGRFSCQINGMTTAIMTRLDIMDILPKISICTAYELNGKIIKYFPANSGELAKCKPIYEEMPGWLCSTKEVRNYDDLPEAAKAYICRIEKLIGCQMSAVCIGPSREQTIYK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYD_PASMU
Sequence: MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEVRVKPEEAYGEYNENMVQRVPKDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVDGNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCGGHHHDSDEEGHGCGCGSHHHHEHEHHAHDGCCGNGGCKH
What is the function of this protein?
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step.  This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity (By similarity).
What are the official names of this protein?
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD, PPIase, Metallochaperone SlyD.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHRA_SHIBS
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHWEDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_THEVO
Sequence: MDEISSMLDYLGIKSTEELFSDIPLSVRKKEIGIGSPLDEHLVLERARKYASLNSTEMLNFLGNGIYDRVIPEAVNYIISKSEFLDSYTPYQPEVSQGMLQSIFEYQSLISDLFKMDFTNASMYDGYSALGEAARMAYRINGKNKILIPESTYDSKLSVLKNYVWGLSMKIEKYKMNEEGKIDIDDLQSRIDGDTSAVVVENPNGYGVIDENVFRISEIKKESLLISYVDPISLGVLKPPGEYGSDIAIAEGQQLGIPMNFGGPLLGIMSFKADYVRKSPGRLIGESVDADGKRAFVMTLQTREQHIRRAKATSNICSNQALLTLAAGSYLSILGSSGLKKVALLTIKHSKNLAESLGNIGIEKVFDSISFSDTLFRIDKNVMLDLAKKGILGGIKLTSLIKDSKYSSGTFFTATEKTDNEKIKALVNALEVIM
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: TRMN6_SHESR
Sequence: MAFTFKQFHIDDLNCGMPVSTDGVILGAWAPLAEAKNILDIGAGSGLLSLMAAQRSQGQITAVELEEKAAAACRYNMTQSPWAKRCQLVHGDIQHVCQLAQYQGYFDHIICNPPYFEHGPKASEQHRAMARHTETLGFTPLLDAISQCLSFEGYASLILPIQSLARFKACLNDTALFLVREVWVKSVENKAANRALLLLSKTEVEPYQRTDLTIRGEDGNYTEQMIELTKDFYLKL
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FERM2_MOUSE
Sequence: MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLIMPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPVTSPEILAKMFKPQALLDKAKTNQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSREESSGTPAHQLNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPDQITTDVNPECLVSPRYLKKYKSKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV
What is the function of this protein?
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself.  Binds to membranes enriched in phosphoinositides.  Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes.  Required for the assembly of focal adhesions.  Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation.  Recruits FBLIM1 to focal adhesions.  Plays a role in the TGFB1 and integrin signaling pathways.  Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
What are the official names of this protein?
Fermitin family homolog 2, Kindlin-2, Pleckstrin homology domain-containing family C member 1.
What is the protein family that this protein belongs to?
Belongs to the kindlin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity).