PharMolix/UniProtQA huggingface dataset:
Protein: SECA_FUSNN
Sequence: MIGSLLKKIFGTKNDREIKALTKEVEKINALESEYEKLSDEDLKNKTNIFKERLKNGETLDDILVEAFATVREASKRVLGLRHYDVQLIGGMVLHQGKITEMKTGEGKTLVATCPVYLNALAGHGVHVITVNDYLAKRDRDQMSRLYGFLGLSSGVILNGLPTDQRKKSYNSDITYGTNSEFGFDYLRDNMVSSLDQKVQRELNFCIVDEVDSILIDEARTPLIISGAAEDKIKWYQISFQVVSMLNRSYETEKIKNIKEKKAMNIPDEKWGDYEVDEKSRVIVFTEKGVKRVEEILKIDNLYAPEYVELTHFLNQALKAKELFKRDRDYLVRDNGEVVIIDEFTGRAMEGRRYSDGLHQAIEAKEGVKIASENQTLATITLQNYFRMYKKLSGMTGTAETEATEFMHTYGLEVVVIPTNLPVIRKDDADLVYKTKKEKINSIIDRIQGLYEKGQPVLVGTISIKSSEELSELLKKRKIPHNVLNAKYHAKEAEIVAQAGRYKAVTIATNMAGRGTDIMLGGNPEFMALAEVDSRDDENFPEVFAKYQEQCANEKEQVLALGGLFILGTERHESRRIDNQLRGRSGRQGDPGESEFYLSLEDDLMRLFGSERVMIWMDRLKLPEGEPITHRMINSAIEKAQKKIEARNFGIRKNLLEFDDVMNKQRTAIYESRNEALAIDNLKDRILGMLQRNITEKVYEKFAPEMREDWDIDGLNEYLKDFYVYEERDDKAYLRSTKEEYIERIYNALVEQYNNKEAELGSDLMRKLEKHILFDVVDNRWRGHLKSLDALRESIYLRAYGQRDPVTEYKLISSQIFEEMIATIQEQATSFLFKVVVNTEPVKDEKNEIEADGLCPCGSGKPYEKCCGR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MAP22_ASPFN
Sequence: MGSKTFEGEGQRGGNDPSNSTSPNSAGGEPRGAHLSRDGDGSLGDGDGDDGADGDEKDGAVTTTPLTEQQPSSETTSKKKKRRKPKKKISALKQSSPPRVPLDDLFPTGQFPVGETHEYGSVVEGTARTTSEEVRYLSRNYLQDDSVLTDYRKAAEIHRQVRHWTQENVRPGQTLTEIAVGIEDGVRALLDNAGLETGQCLQSGMGFPTGLALNDCVAHYTPNPGQKDIVLQASDVMKVDFGVHINGWIVDSAFTMSFDPTYDNLLAAVKDATNTGIKNAGIDVRISDVSAAIQEAMESYEVEIGGKVFPVKPVRDISGHNINRYQIHGGKSIPFVKNSSQTKMEEGEIFAIETFGSTGRGSTVEGFGVYGYGKDPNAPKKVSSPLASARSLYKTINENFGSIVFCRRYLERLGVERYLAGMNSLVNNGIVEQYAPLMDMKGSYSAQFEHTILLRESCKEVVSRGNDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_BIFLO
Sequence: MISIIIQILLISVSVAMDAFAVSIGKGLTVSRVRVQDAVKSTLWFGGFQMLFPILGYFAASTFSKYVTQFDHWIIFALLVFIGGNMVHEAFEEDEENSKETAQFDWKHMLPLAVACSIDAFAVGVSLAFMFTKAHMAFAILSIGVVTGLFSAAGLHIGRAFGSRWQKPAQIAGGVVLILLGIKVLLEHLGVIAF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SMG8_DROPE
Sequence: MGLKDYYTWTFPNIPEHVAQELDQLGRSLVVVGVIGRSRCVLANKMRAFGMEPPVDHEPTDGQLQCYYKPGSSTLLLHFETTFDDAILGQQIDETMEQDGAPFDFDGFYERMKCRFVRMMLLALHVCHILVYVETGQTFDLSLVTIFQLMKFAREQHLMQFLPSLLKETPAGRLLGEKCRLCTPRILFLFENFTHEEGKTRECVSACEFQTEDSIYELLRHHQIITNSSSSSLLALPNNKQFVFYNAHDQLHADRLLQSIEFLNLDMRKLDVKEEEDDLEVLELAPFDGFVKSFGESFESTNYEEQQYKTEHTAWHFLQRHVQDALLGCFDEGSFKQVPQRGQLQLLNAQEWHDCIAELHKLLVSSAGTQESLNEIRNEDYQVFLQSFDESLNYEKKFWAHLCEIGLKMGIEAYKKAAPAIYGSSMHQQLLAEATLAFEEEGRGPPAEASIAKMTATCLRHWQDGRQQCEQLSLRSQPCTQPKEMPHDKHNSGVIHVSSCNCGRTQGRREDPFSLRQANYEFYEHMVKMCNLCVKVKQFKFPIFEPTNNEYRAAAFEVAFPLLHAGKNRLAQDAELDPDEEDEELPTGEREEQHITQSNGCSQPLSPTFGSDLNMSIAGFGVSLNESEPCFDQSSSSEAESTCSGTSSEESNNELVLQLKEPAKKHEESCDPDSIAPLPSMCLTSTTEYLPGLVHTLSKVGLLPLFPSWSLACVGPSSIYSHNTGLQEHFQSGFLSGANFLLPWDVQLRLVHASKHYHNSHQPHMSKKQQRYRKHGDRMVLKIFVGFEYECSRGHRFMMCRPDRVLRGGADIERDTCSKMVHTNMPLYYPCPCRSQNNYLAQLMRIHVVTPKAPVNIIVDPKVCMGKDKYTFTLGSMVPPRLSQSAYWILRLPYVYQGDDALIAPPEKLEPDDIMAGGYLLAGMFGIAETDPTLDLNDQGHLDTNELGTFTRI
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG8, Protein smg-8 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMG8 family.
Protein: GCS2_ECO24
Sequence: MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAAADHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKMGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: RS8_FLAPJ
Sequence: MYTDPIADYLTRVRNAAKANHKVVEIPASNMKKEITKILFDQGYILSYKFEDNAVQGSIKIALKYDKVTKESVIRDIQRISKPGLRKYSGSSTIPRILNGLGIAIVSTSKGLMTGKLAKQLNVGGEVICYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: EPMA_VIBC1
Sequence: MQTTWQPTASMEQLRQRAALITAIRQFFAERQVMEVDTPAMSHATVTDIHLHTFQTEFVGPGYADGSKLFFMTSPEFHMKRLLAAGSGCIYQINKAFRNEENGRHHNPEFTMLEWYRIGFDHHKLMDEMDDLLQLVLKCGAAERMTYQQAFIDVLGVCPLEGSMQELKVVAAKLGLSDIAEPEEDRDTLLQLLSSIGVEAKIGQQVPAFVYDFPASQAALAKINPQDIRVADRFEVYFKGIELANGFHELDNPKEQLARFEQDNAKRLDMGLKPQPIDYHLIGALEAGLPDCAGVALGVDRLIMLALGCDHIDQVTAFPFPIA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: PUR7_CAMJE
Sequence: MTKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCKISTEIFHLLEKNGIKTHLVEIISDTEQVVKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIELGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MEPA_STAAM
Sequence: MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMANKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLLIAESLCALAAMLIVYLLRDRLTVDTSELIEG
What is the function of this protein?
Multidrug resistance efflux protein.
What are the official names of this protein?
Multidrug export protein MepA.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHAD_ENTFA
Sequence: MNVLQAPFVEEMVKTTKNLYRLGWDERNGGNISYLLKEEEILPFLNPTQVLRKIPMKFDATKLAGKYFIVTGSGKYFKNVCDASSENLGILRVSENGQELELLWGLEDEAVPTSELPSHFMSHIARLAVDPENRIVMHNHASHLLAMSFTHELDEKVFTRTLWQMCTECLVVFPDGVGIIPWLVPGTNEIGVATAEKMKESRLVLWPQHGIYGTGRDMDEVFGLIETAEKAAEVYTYVCAQGGVRQTISDADLWRLAEAFGVTPKVGYLEEKVSKRRKL
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCA1_SOLLC
Sequence: MARQATKLIANLSKKLSSSNPHTRCSEQTVWIGAAPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVEEAKAETKANASVIYVPPPFAAAAIMEGLEAELDLIVCITEGIPQHDMVRVKAALKKQSRTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFIADPQTEGIVLIGEIGGTAEEDAAALIKESGTQKPVVAFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALKEAGVTVCESPAKIGVSMLEVFKQRGLV
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial, Succinyl-CoA synthetase subunit alpha-1, SCS-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MSCL_TOLAT
Sequence: MLGEFKKFAMRGNVVDMAVGIVIGAAFGSIVKSLVDDVLMPPIGLLLGGVDFSDFFVVLKEGVKAAAPYQTLAEAKAAGAVTLNFGLFVNAIISFTIVAFALFMIVKAMNKLRADEEVKPVTTKKCPHCCSEIALEATRCPHCTSEL
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THIM_MAIZE
Sequence: MDVGAKEEEMGQVWWGHRAWSLLSAVRARAPLVQCITNLVSMDIAANVLLAAGASPAMVHSLREVPDFTPRCDAVYVNVGTLSEDWLPSMRAAASAGRPWVLDPVAAAASGFRMKACLELLSLCPAVVRGNASEILALASRSTAASSNFKGVDSSHCSVDAIEAAKALALSSSAVVAVSGAVDFVTDGKQVISVSNGVPMMQKITATGCAVTALIAAFVAMEPSDAIVAAACALAIFGLVGEIGMESAKGPASLRMHLIDALYCLNEETVTSRVRISLRP
What is the function of this protein?
Thiazole kinase involved in thiamine salvage pathway.
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: ISCR_SHIB3
Sequence: MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRTQDAIDVKLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.
Protein: MOAA_SYNSC
Sequence: MSTSLPLADRLNRPIGVLRLSLTARCNLACPYCCPDVEEPPGLLTLEQQIRVIRVATRLGVQTLRLTGGEPLLSRRLLPLLEAVAQARRDRSDPMAGLQAVALTSNGVLLSEPMGRALRAAGLDRITISLDAAEGEAAARMAGLQGGAVAGERLVRQVQDGIAAAFAAGFDPSRGELKLNAVIQRGINDDQLLPLAALARQRGMELRLIEYMDVGNRNQWTLDQVLPAAQMVERINARWPLEPLGRPRGGTARRWRYGDGAGSIGVISSISEPFCGDCNRLRVTADGQAFTCLFSAEGTDLKPALASDLQLEQAMRQLWQRRQDRYSEERDPAAAASTHAEMAYLGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: ST3A1_RABIT
Sequence: MDNSRKYLLNFKGCNFERTLVDMKILEKLDDFEIRDDDVFVITYPKSGTVWTQQILSLIYFEGHRNRTEKWDTLDRVPFLEYNIRKVDIENRPSPRLFASHLPYYLAPKSLKNNKAKIIYVYRNPKDVLISFFHFSNMVVKLEASNTLENFMEKFLDGKVVGSIWFDHIRGWYEHKNDFNILFMMYEDMKKDLRSSILKISSFLEKDLSEEEVDAIVRQATFENMKFIPQANYNNILSNEIGRRHNEGAFLRKGAVGDWKHHMTVEQSERFDRIFQEEMKDFPLKFIWDLNDEANSNHSAK
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines (PTHP, aniline, 4-chloroaniline, 2-naphthylamine).
What are the official names of this protein?
Amine sulfotransferase, AST-RB1, Sulfotransferase 3A1, ST3A1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_BORPE
Sequence: MTIGLSVTNDVFARDILTVAQLNQAVGQLLERSIPSLWVRGEISNFTQAASGHWYFTLKDSRAAVRTVMFRSRAAQVGFVPRPGDQVEVRARVSLYEPRGDYQLQADGMRRAGVGNLYEAFLRLKAQLQDEGLFDPQRKRQPARLPRAIGVVTSLHAAALRDVLSALARRAPQVPVIIYPAPVQGADAAARLAARVAQANQRAEVDTLLLVRGGGSIEDLWSFNDEALAREVAASDIPVISGVGHETDFTIVDFVADLRAPTPTAAAELACVPRGDLLAALRHTAEWLARAQQRRLDQAAQRLDRAAAMLTSPAQRLAHQQERLNTLRHRLASAWRGPQGHRVARLDMLAQRLAHRRPDTGRAAERSAALLAQLGRAQARLAAARQARLDTLAAQLRALDPQHTLARGYAIVRDAAGAIVTDATRLAARDRIEIAVARGRIGADVTDIGTPDGTDGNPALRRG
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_CHLPB
Sequence: MAEQQDARVYSDRRHEMVEQLKRYGITNSKVLEAFNAVERHLFFDAAYRDFAYDDGAFSIGYGQTISQPYTVAYMTSMLVERCPSGKVLEIGTGSGYQAAILEYMGYSVYTVERIEALFRRSSLILGALGLTVHQILGDGTLGWEEEAPYSGIIVTAGAPEPPSALLGQLAEEGVLIIPIGDSTGQRMTVFTRRGEMFQREEFHTFAFVPLIGREGWREE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_LACLS
Sequence: MTVSFEKTSDTKGTLSFSIDQETIKTGLDKAFNKVKANISVPGFRKGKISRQMFNKMYGEEALFEEALNAVLPTAYDAAVKEAAIEPVAQPKIDVAKMEKGSDWELTAEVVVKPTITLGDYKDLTVEVDATKEVTDEEVETRLTNAQNNLAELVVKETAAENGDTVVIDFVGSVDGVEFEGGKGSNHSLELGSGQFIPGFEEQLVGTKSGETVEVKVTFPENYQAEDLAGKEALFVTTVNEVKAKELPELDDELAKDIDEEVETLEELKAKFRKELEESKSEAYDDAVETAAIEAAVANAEIKEIPEEMIHEEVHRAMNEFLGGMQQQGISPEMYFQITGTSEDDLHKQYEADADKRVRTNLVIEAIAAAESFTTSDEEVKAEIEDLAGQYNMPVEQVEKLLPVDMLKHDIAMKKAVEVIATTAKVK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RS5_PSYA2
Sequence: MARNDKNDKNEQTDGLVERLVTVDRVAKVVKGGRIFSFTALTVVGDGNGRVGFGRGKAREVPAAIQKALEAAKRNMITVELNDATLYHPIKARHGASKVYMQPASEGTGVIAGGAMRAVLEVAGVKDVLTKCYGSTNTANVVRATFNGLRDMSTPEKMAAKRGKSVDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DTD_HAES1
Sequence: MIALIQRVSHAKVEVGQNIVGQIGQGLLVLLGVEKDDDRSKADKLAEKVLNYRIFTDENGKMNLNLQQIGGEILIVSQFTLAADTQKGLRPSFSKGADPELAEKLYQYFSQKCAEKVRVANGQFAADMQVSLTNDGPVTFWLNV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LE194_HORVU
Sequence: MASGQQERSELDRMAREGETVVPGGTGGKTLEAQEHLAEGRSRGGQTRKEQLGEEGYREMGHKGGETRKEQLGEEGYREMGHKGGETRKEQLGEEGYREMGHKGGETRKEQMGEEGYREMGRKGGLSTMNESGGERAAREGIDIDESKFKTKS
What is the function of this protein?
Lea proteins are late embryonic proteins abundant in higher plant seed embryos.
What are the official names of this protein?
Late embryogenesis abundant protein B19.4.
What is the protein family that this protein belongs to?
Belongs to the small hydrophilic plant seed protein family.
Protein: PSN1_BOVIN
Sequence: MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDSRERHEHGNERRRRGNTESVSNGRAPSSSQQVVEQEEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVAQRALHSILNAVIMISVIVIMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAMDYISVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVSKNSNYNAQRPANSPVTTTGTESESQDPVTESDDGGFSEEWEAQRDSRLGPHHSTAESRSAVQDLSSSILASEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPVSITFGLIFYFATDYLVQPFMDQLAFHQFYI
What is the function of this protein?
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the presence of the other members of the gamma-secretase complex for protease activity.  Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.  Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin).  Under conditions of apoptosis or calcium influx, cleaves CDH1.  This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity).  Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).  Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity).  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis.  Involved in the regulation of neurite outgrowth (By similarity).  Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity.  It acts through the control of SYT7 presynaptic expression (By similarity).
What are the official names of this protein?
Presenilin-1, PS-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane; Multi-pass membrane protein. Cell projection, growth cone. Early endosome. Early endosome membrane; Multi-pass membrane protein. Cell projection, neuron projection. Cell projection, axon. Synapse. Note=Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. Colocalizes with UBQLN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes.
Protein: RL2_LIMF3
Sequence: MGIRKYKGTTNGRRNMNGYDFAEITKTTPEKSLLAPLKHTAGRNNAGKMTVRHRGGGTKRQYRIIDFKRIKDDVPATVKAIEYDPNRTANIALLGYADGTKSYILAPKGLKVGMTVQSGPDADIKVGNTLPLKNIPVGTVIHNIELKPGKGGQLTRSAGTSAQLLGKEEKYVLVRLSSGEVRMILAACRATIGSIGNDEHGLLVKGKAGRSRYAGQRPHVRGSVMNPNDHPHGGGEGKAPVGLPSPLSPWGKKTVGKKTRSHKARSNKFIVRGRKRGPHTR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.