PharMolix/UniProtQA huggingface dataset:
Protein: DABA_RHOCS
Sequence: MLMTATGSPFLTAETIIVAADRAARAIPPLWPLASSVAVNPFIGQAGDTLPTAAARLRRAAGIALTMPRSWYAERLRSGEIAEGDLQAAFDAAPAELRPKTLAALKQAAHAQGTRPPALPTVAELARDLDSIDWPGIVNDRIGHWASGYFDQGQALWATAQAQRAYAAWRTVATHDLTPEIAGLAGFAQNVADAPADAEAALVRCVTRLGLSGAALESYFHRLLMTLGGWGQIARYRLWQAELTGNTDASVVDLLAIRLTWEAALLRQYGAALEPQWQAAIAAYARPVAATLEDGVDAILQEAAERAAQRRLHSLLSETPSALAAPGRPALQMAFCIDVRSEVFRRALESLDPGIRTLGFAGFFGLGIGHRRFGSDVVEARLPVLLRPGVFTCSGEATPAIDKADLTARITARAKRAWGRFKLAAISSFAFVEAAGPIYVGRLLRDGLALPRPSAPNDPAPRPADDLGFDTRLGMAANVLRAMSLTEGFARLVLLAGHGASVVNNPHASALHCGACGGYSGEVNARLLAALLNDRDVRAGLASQGIRIPDDTVFLGALHDTTTDEVTVYAADHPSVAHAGDLERARRWLTSAGVLARGERALRLPRAARSQDIPHRARDWAELRPEWALAGCQAFVAAPRERTAGRDLEGRAFLHDYDWRRDKGFGVLELILTAPVVVASWISLQYYGSVVAPDVFGAGNKLLHNVTGGIGVVEGNGGLLRSGLPWQSVHDGEQLAHEPLRLSVLIEAPREAIAGILERHPGVRTLFDNRWLHLFALDDEGHMAWRYTGDLRWENCSRDAASGRIPLRELA
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DTD_ALKOO
Sequence: MRAVVQRISEGKVVVDDAVTGAIKKGLLVFLGVTKEDTMEDVQYMAEKIVNLRIFEDQEEKMNLSVKDVGGKILAVSQFTLLGDCRKGRRPSFTEAARPETADKLYEAFIEQCEKLDIKVEKGVFQAHMMVHLVNDGPVTMLIDSKKVF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBJ_LOLPR
Sequence: MADTTGRIPLWLIGTVTGIPVIGLVGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SPCS3_DICDI
Sequence: MHSLSQRANTIVCFGGIVLVGVLLLNVLSRAFFSDHVDVDIKLNEIHRFNTQRNFEYSFISIDLDANLEPLFNWNTKMLFLYVTAEYRTKQNVLSQVVVWDHILTEKSKANIHEKRLSKYPIINQGLGLKNNTIKLTFNYNVVPISGILTRHQVGTSEFKFPTTYMKEAY
What is the function of this protein?
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the SPCS3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RL25_TRIV2
Sequence: MALTVETKKRPEGSKPKALRRSGFIPANLYGHNGRESISLVVDAKVVERLLKAAAVKKTEIELNIPELEWTGKTVLQEVQIHPAKGTPYHISFLATAKG
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: EFTS_CLONN
Sequence: MVTAKMVKELRERTGAGMMDCKKALTETDGDMEKAVEFLREKGLAAAAKKAGRVAAEGLVTTYLSEDNKTAVALEVNCETDFVSINESFVEFTNSIAKQIATSDVKDVEELLESKYIADENVTVKEALTALIAKIGENMNIRRFEKLTIDNGVINGYVHGEGRIGVLVELGCEKESDILMPLAKDIAMQVAAANPLFLDETSVDEEALDKEREIYRAQALNEGKPEKIVEKMVEGRVKKYLKEVCLIDQVWVKNSDYTIKKLLEEKSKEVGSPITLCKFVRFERGEGLEKKEENFAEEVQRQMNQK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHE_WIGBR
Sequence: MKIKNKSMVYWSCRRGMLELDIIINNFFKKEFDFLSNKEKIFFVNMLSYDDIYLYKCLIFNYEPKNKKIKKIIKLIKRSSFSFS
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIAO1_DROPE
Sequence: MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRVWSLSGNTWSTKTILSDGHKRTIREIRWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNAHTQDVKRVVWHPTKDILASASYDNTIKMFAESQLDSDWDCTATLSSHTSTVWSIDFDAEGDRLVSCSDDKTLKIWRAYHPGNDAGIATPDKQSVWKCVCTLSGQHSRAIYDVSWCKLTGLIATGCGDDGIRIFKETSDSKRDEPTFEQLTAEETAHEQDVNAVEWNPAVAGQLISCSDDGTIKIWKVAD
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein Ciao1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: ISCA_ECO7I
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFTNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RL16_EHRRG
Sequence: MFIPKKTKYKKDFKGRISGNAKGGYTLAFGTYGLKSLEPGRLTSKQVESARRSISRTLKRVGKVWIRVFCHTPVSKKPMDVRMGKGKGSIEMWVCKVKPGKILFEISGVSLNLAKEALQKSQAKLPVKCKFISDEL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HEM1_CLONN
Sequence: MNLAVIGINYNNTPIDIREKVSFSKSQKYKACTYLIKKGISEIIIVSTCNRSEIYICSDEIDSHINEVVNFYKIFFNVESVNEYIFIKKDKEAVSHIYNVSAGLDSMILGEDQILGQVKEALRYSMENKFSRKVLNKLFREAITSAKKIKSELKISETPISMVYIAIKLLEKNIGTLKGKKACIIGAGDMGRLALKHLINEELEEIFVANRTYNNVIDLLKEFPKIKLIDYEKKYEILDNVDILITATAAPHLIIKKEQLQNIKQELYIMDLALPRDVEKSAGDIENIHLYDVDDFKNISDSNKIKREELSLIAKDSIDSYVNEFNQWMKSLKVDNTIKDLNNRCRDIKDEYLGYITKKIDLNERDKEILEKMLFGALKKVVKEPILNLKELKDEDEINKYIKSVNELFKF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: HEM3_RICB8
Sequence: MINSIRIGTRKSKLALTQTNLVIEQIKQHFPNINCEIVEITTSGDLIQNKPLYDIGGKALFLKEIEQALLNKKVDLAVHSLKDVPGIIPKDLSIEAVLEREDSRDVFVCLTHKSIEELPKNAVIGTSSVRRKLCVQRMRPDLEIIVFRGNVDSRINKLINKEVDATILAYAGLKRLNAFNPEYCHLIEHSQMLPCIGQGVIAIEIRKDDHDMIEICKQINHLPTFELIKPERALLEYLDANCRTPIGAYSKYLDNGDIQTDFMLGNLDGSKIAFHTEISNPKTSKESGIKAAKVMLLSLS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NDUS2_PYLLI
Sequence: MALKKKEFNKKLKHFTINFGPQHPAAHGVLRLILELNGEVVQRADPHIGLLHRGTEKLIEAKTYFQALPYFDRLDYVSMMCQEHTYALSVENLLQVSIPRRAQFIRVLFAEITRILNHLLAVGCHAMDVGAMTPFLWAFEEREKLMEFYERVSGARMHASYFRPGGVSQDISVGLVDDIFAFVAQFGQRLDEIEEMLTDNRIWQERLVDIGVVSAQEAIDWGFSGVMLRGSGIRWDLRKNEPYEIYSDLNFQGVVGKTGDCYDRYLARVEEMRQSLSIIYQCLNKMPRGSVKIDDAKISPPSRSEVKQSMESLIHHFKLYTEGVFVPAGETYTATEAPKGEFGVYLVSKGSSRPYRCKIKAPGFSHLQGLNFMACSHMLADVVTIIGTQDIVFGEVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  Component of the iron-sulfur (IP) fragment of the enzyme.  Component of the iron-sulfur (IP) fragment of the enzyme.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 49 kDa subunit, NADH dehydrogenase subunit 7.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MOAE_CERS4
Sequence: MRVLVQAEPFEFGAEAQTFADGAAGAGAIVTFTGLVRDLSGALEAMEIEHYPGMTERAIAAIAEEARQRWHLIDALVIHRHGRLGPSEPIMMVATAAAHRAEAFAAAEFLMDYLKSRAPFWKKEVTAGGADWVAAKEADEAALGRW
What is the function of this protein?
Converts molybdopterin precursor Z into molybdopterin.  This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group.  The sulfur is provided by MoaD (By similarity).
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the MoaE family.
Protein: RPOC_VESOH
Sequence: MRDLLKIHKLEQKEQDFDAIRVGLASPEKIRSWSYGEVKKPETINYRTFKPEREGLFCAKVFGPMKDFECLCGKYKRMKFRNVVCEKCGVEVTYSKVRRERMGHIELAAPVAHIWYLKSLPSRLGLLMDMTLKDIERVLYFEAFLVTDPGSTPLVHKQLLTEEMYFDALDEYGDDEFEAKMGAEAIQDVLSDMKLEVEAANLREDSLNTKSQTKLKKYNKRLKLVNSLIQSGNKPEWMVLKVLPILPSDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLARLLELDAPEIIVRNEKRMLQEAVDSLIDNGRRGRAVMGNNRRPLKSISDMIKGKQGRFRQNLLGKRVDYSGRSVIVCGPYLKLHQCGLPKKMALELFKPFIYNRLQTKGLASTIKAAKKMVESESPEVWDILERVVHQHPVLLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCGAFNADFDGDQMAVHVPLSEEAQLEARTLMLASNNVLHLASGEPIIVPSQDVILGLYYMTREMINQKGEGLIFVNATEALNAYESDSVTLHAKVKLRIQDYHKVNGKFEPSAKRIVDTTVGRAIFSRILPNGLSFNLINEAISKKVVSNLIHVCYRTQELKQTVMFADQMMYMGFQYSTKSGISFCSNDMIIPDSKAKMIEQAEIQVKDIQEQFSKGVVTDGERYNKVIDIWSRTSEKVAKAMMDEIGFENFTDVDGKIQKLASFNSVYMMADSGARGSPAQMRQLSGMRGLMAKPDGSIIETPITSNFREGLNNMQYFISTHGARKGLADTALKTANSGYLTRRLVDVGQDLVITENDCGTDNGLIMKAVIDGGNIVQTLGTATLGRVTAEDVLMPDSIEIFLEKGHLVSLDDSDKINELGIESIKVRSSITCDTRYGVCSSCYGNDMARGHKIGVGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASASTAVSSINVNTDGIAHFENLKSITNENNDLVVISRSSEVTIRNNKGQEVERYKIPYGAIVHVQEGGAVTAKDKISDWDPHTHPIISEQAGRVIFVDFVEGMTVNKNTDPLTGLTFFEMIDEAERSTAAKGLKPLIKMVEENDSEVVLSTHYLPSTVKINLDDNQVIAAGGVLAKIPKDLSKTSDITGGLPRVADLFEARKAKDHSILAEATGVISFGNSTKSKDRLIITSSEGKATEMMIHKWSQINVFDGETIEKGDVISDGPSNPHDILRLLGVEALANYVVREVQNVYRLQGVNISDKHIEVIVKQMLRKVEILDAGDSSFVNGETAEYGRVIEMNYQLEAQGKDLINYQRLLMGITKASLATESFISAASFQETTRVLTEASTTGRVDTLQGLKENVIVGRLIPAGTGFKHHQVRRAQYVESITTQTVDAQQALSDQLKEAEEQT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RBR2_ORYSJ
Sequence: MASQPPAAVEARLADLCKELGVDEGVAGEAAAVLEEGKGALLASPSFGSKSPEDAEKLCFAFVLYCVSKLKETKAGSSGVRLWEILKGCKLKYDDFFKESQRLASRIDQVLGSRYGSDWEARLELKQLENLVNLLADASRFYCKAFNELFLSPSTDQEPGSTTNIPDYIRFGWLLFLILRSKSPELFKDLVSCIHGLVAILAILLIHVPAKFRSFTIEGSSHLIKQTEKGVDLLPSLCHNYHTSEDRLKEMMGKSYKVIEVFFSRKAINASEFKTVNLDKIDTDGLMYFKDLVDDEIFQSNLEKLEKLSSTTGCQGELDLEMFLTSNDYVLNAENSSGSSANFGCSKRVFETLASPTKTIKNMLAAPSSPSSPANGGSIKIVQMTPVTSAMTTAKWLRDVISSLPDKPSSKLEEFLSSCDTDLTSDVVKRVSIILEAIFPTKSIDRGTSIGLNCANAFDIPWAEARKMEASKLYYRVLEAICRAESQNNNVNNLTPLLSNERFHRCLIACSAELVLATHKTVIMMFPAVLESTGLTAFDLSKIIENFVRHEETLPRELKRHLNSLEEQLLESMSWEKGSSLYNSLVVARPSLSTEINSLGLLAEPMPSLDGIVARQSIHPDGLPPTPSKRWPSAGPDGNCYPQSPKRLCTESRNSLVERNSQTPPPKQSQTGLSILKAKYHPLQATFASPTVSNPVSGNEKCAVVGVQIFFSKILKLAAIRIRNLCERLRHEELTVSVYNIFKQILDQQTALFFNRHVDQIILCCLYGVAKVSQLSLTFKEIVNNYKREPQCKPEVFRSIFVGSTNRNGGFGSRHVDIIVFYNQVFVPTVKPLLVALMPSSTRPEDKRNTNSQIPGSPKSSPFSNLPDMSPKKVSSSHNVYVSPLRQTKMDALLSPSSRSFYACIGESTQAFQSPSKDLAAINSRLNYPTRRINTRINFDMVSDSVVAGSLGQPNGGSASSDPAAAFSPLSKKSKTDS
What is the function of this protein?
Regulator of biological processes that recruits a histone deacetylase to control gene transcription.  May play a role in the entry into mitosis, negatively regulating the cell proliferation.  Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication (By similarity).
What are the official names of this protein?
Retinoblastoma-related protein 2, OsRBR2.
What is the protein family that this protein belongs to?
Belongs to the retinoblastoma protein (RB) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATE2_BOVIN
Sequence: MALSDVDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSTLRNQARLKVLRARNDLISELLNDAKLRLSRIVTDPEFYQGLLDKLVLQGLLRLLEPVVIVRCRPQDHFLVEAAVQRAIPQYTAVSHRCVEVQVDKEVQLATDTTGGVEVYSSDQRIMVSNTLESRLDLLSQQKMPEIRKALFGANANRKFFV
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
What are the official names of this protein?
V-type proton ATPase subunit E 2, V-ATPase subunit E 2, Vacuolar proton pump subunit E 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: STS1_CLAL4
Sequence: MSTPAFSLRNPENHARCAKPLRKRKLSPPQIDTPRSFSPSRQKRAKTTKILGQSLPVHRIIETLDRNALQSLLQQVAAANPQVAQSIVDLAPKPDTKDALAVMRAKFDAITAHLPYKCSAESDYSYTRVKPYLCEFLSTLSDFILNMLPPLEVDLQPACTILDAITEMIHKLPNFSNSEFQYTRAMAYDQLSTSWQILLDAADERLLVRVEAEMGLSRRLQKHNELSGGKLTQAVESAGRGQSPLLGGLITVDYSSFRH
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TDRD1_DANRE
Sequence: MNPAFAQPMMRPNLPLRRPATGPSSLSPRGPAPAIYEERLLASDVLDGPKIDTMRKDISQNCGDVLSSPQTAVSMMGQVVKLCNYCSHQGNLRCTRCKKTCYCSVACQTQDWIAHRHVCKPSIPEVTSEKPKESKAVPYANGLGGTQAKEISVDAQPKRIYRRDLHKKVVSKGSEIKGTVIDLRNPGMFSIHCQCEEMIESLKKITQQLQKTYCSSFAQEYKPEVGELCAVKFSLDQNWYRAEIQAVDVARKTAGVFYIDFGNEENVALDHIRPLSENIDAVPPFALQCCIAGVKPLTGSWTGECCIAVRQLIAGKSLTFTVLDIMNDGDLLAVDSLVSTLGKHVSTFLIDQSYAIKEDVPVKTQTEHSISSLLTASFENFKRFSGGKNENSEARPPEPLTQGVGDSFTAVVTHLQSPSEILCQKLENASIIQQLQMNLRVHCSNTAASDDFRPAPGTVCCSLFSEDNQWYRAKVLAYSSEDRVCVGYIDFGNSEEVELNRLRPISKELLALATQAIPCSLAGIKSLTDTWSDEAVLMLKHLVCNRFIRVEILGKKDGRALVSMIDESSDPQASVTELLVNMGFAAIESVETKKNEPDPATSTEIPLSQPVVEKLEWTGAELPFDGQKVELVISTLKSLDEFYCYNYSKTDEHTLTEMSFELMKHCESERAPFTPIVGEPCCALFTGDARWYRAMVLEVCGEGKARVCFVDYGNSCEVDAAHLKAITQSLLKLPFQAIRCWLAGVEPVEGQWKKEAMLRFQALCAGQPLSGKVLSITEKGYGMELESAGQTVASVLISEHLAKPYGQVRQPPQIQPAKPASQIEDLPSLKPIDQNPSVEEPLKVSSKGAATTPEDLPVSSGCFPLNWKTLELSCSGTFQPRVAAVISPSLFYIMNPGQVNVEGLKAVMTDVAKYCSKQPVPNQCHPLPGASCCAQFSGDKNWYRAVVLEVTTKHAHVIYSDYGNMETVPLSSILPITKELLQHPFQIVRCALTGKEHFPVVWPTEVLELFGIQLSGGVLASFQGFDGTSNLLTLTQQSGQSDRDINSIILGALQKGQIKPSSKLPANVNEEKKDVEQKQTQPISSNKAVEQTLSTNVEKPALDDQTLPLSVSLKHEEPENMSKTKTAEECTSTPDTVSSIESSHAAQSCCCQELKQKMDRIEELVLLLVKQVGSR
What is the function of this protein?
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Required for the localization of Piwi proteins to the meiotic nuage.  Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway.  May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TDRD1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: SZRD1_PONAB
Sequence: MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSSPNSTSRPTLPVKSLAQREAEYAEARKRILGSASPEEEREKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR
What are the official names of this protein?
SUZ domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SZRD1 family.
Protein: TRUB_MYCSJ
Sequence: MSGAGVGGGIVIVDKPAGMTSHDVVGRCRRIFGTRKVGHAGTLDPMATGVLVVGIDRATKLLGLLTATDKSYEATIRLGQTTTTEDAEGDVVETTPATGITDEQIGHAVAALRGEIDQVPSAVSAIKVGGQRAYKLAREGQTVELAARRVRIDRFEVLAIRRVDGFVDVDVAVDCSSGTYIRALARDVGVTLGVGGHLTLLRRTRVGRFGLDEAYPLDALADEPRLSHSLDEACLLSFPRRDLTPAEAESTRHGRALAPAGIDGVYAAAAPDGSVLALLEDGPQRTKSVVVLRPATL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: IFT56_HUMAN
Sequence: MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQSEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMIRIMKKWAKENRVSI
What is the function of this protein?
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium.  Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly.  Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU.  Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components.  Not required for IFT complex A ciliary localization or function.  Essential for maintaining proper microtubule organization within the ciliary axoneme.
What are the official names of this protein?
Intraflagellar transport protein 56, Tetratricopeptide repeat protein 26, TPR repeat protein 26.
What is the protein family that this protein belongs to?
Belongs to the IFT56 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Localizes at the base to the ciliary transition zone.
Protein: OTC_RHOBA
Sequence: MMRHLLTLFDLTPQELRQILATAQTLKAKLKQGERPAILERYTLALLFEKPSLRTRVSFETGMNHLGGSSLFLGDDVGWGKRESPSDFTRVLGQFVDAVACRAKSHERVEQLAEYNAVPIINSLTDLCHPCQAIADVLTLLENFGEVKGRHMVFVGDGNNVSRSLALACAMLNIQFTLARPDGYELDQPWLDRILAKYPNAKMNQTADPIAAVQSADAIYTDVWTSMGQEAESIARRAAFKNFQVNEQLLEAAPKTARVLHCLPAVRGEEITDAVMDGPQSDVIEQAGNRMHAQKALMIQLLRPEWIAENIRV
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_RICPR
Sequence: MARIASVNIPDNKRLVVSLTYIYGLGSTMAAEICNKAKISKDKKVKVLTDQELISLRNIIENEYKVEGDLKREVTLNIKKKKDIRCYQGLRHIRKLPVRGQNTHSNARTRKGKAIAIAGKKKTVK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.