PharMolix/UniProtQA huggingface dataset:
Protein: HFQ_XANOR
Sequence: MAKGQSLQDPFLNALRRERVPVSVYLVNGIKLQGTIESFDQFVVLLRNTVSQMVYKHAISTVVPARNVRVGPGGGYVQSNEGNQAEDDDVEQ
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: TTCA_SALSV
Sequence: MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSLEALRLDVIEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDH_ANADE
Sequence: MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPMVVGHEYVGRVERVGAEVEAFRPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPGSFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALSFDLVGEDVLVTGAGPIGVMAAAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAREDLRAVMSELGMREGFDVGLEMSGNGRAFRQLLEVMNHGGRIALLGIMPGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMVAMLQSGLDLSAVVTHRFSIDDFQQGFDVMRSGRSGKVVLDWGVAR
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_ONYPE
Sequence: MSLTNLFKLQSSLKPSGDQPQAIQKLVNNFKQGLQEQILLGATGTGKTFTIANIIQHLQQKTLVIAHNKTLAGQLYNELKAMFPNNRVEYFISYYDYYQPEAYVASSDTYIEKDSKINDEIDQLRHSAAGSLLNRDDVIVVASVSCIYGVGDLKDYQKSTLHLQIGDKYERQALINKLIELKYQRNEINFQRGTFRVRGDIIEIIASSSKEIGIRIIFFGNEIENIQNFDVLNGKAITNLKLITLFPASLYATNTQKLQEGIKRIRQELKEQINHFEKTNQLLAAQKIKMRTLHDLEMLEQIGNCNGVENYSRHLALKEKGEAPSTLIDFFGNEFLTIIDESHVTIPQIKGMYFGDFSRKTNLVNFGFRLPSALDNRPLKFHEFQAKMNKVIYLSATPGNYELTKKIPIVEQIIRPTFVLDPEIEIRPTHNQMDDLYFEIKHQTKNNQRILITTLTINMSEDLTAYLKNLCIKVAYLHSEIKSLQRLEILKDLRLGKYDCLVGVNLLREGLDLPEVALVAILDADKQGFLRNERSLIQTIGRAARNITGKAIMYADCISPAMQIAIEETYRRRKIQQQYNETMKVTPTALNKTILETISIKQKESAQNENENGKVKGQKKLQTHTNITAKNKEIKRLQKMMKEAAKTLDFEKAATLRDLILELEKKGKLK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_LISW6
Sequence: MFKHETVLLHETVDMLEVKPDGIYVDATLGGAGHSEYLLNKLNEQGHLFAFDQDQTAIDNAKMKLADYSDKVTFIKANFRYMKEALNERGIEAVDGILYDLGVSSPQLDERERGFSYHQDAALDMRMDQEQELTAKIVVNEWSYQDLIRIFFQYGEEKFSKQIAREIERRREVKPIETTGELVDIIKTAIPAPARRKGGHPGKRTFQAIRIAVNDELGAVEDSLEKALTLLKPGGRISVITFHSLEDRITKHLFQEATKGPELPPGLPVIPDEYKPDFKLATRKPIVPSEEELEQNNRARSAKLRVIEKIIK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_MYCSK
Sequence: MTAATHTKAQVLAAALPWLKQLHGKIVVVKYGGNAMTDDTLKAAFAADMVFLRNCGVHPVVVHGGGLQISAMLKRLGIPGDFRGGFRVTTPEVLDVARMVLFGQVGRELVGLINAHGPYAVGITGEDAHLFTAVRRDVVVDGVATDIGLVGDVEHVNTEAVRDLIAAGRIPVVSTIAPDANGVVHNINADTAAAALAAALSAEKLLMLTDIEGLYTDWPDRNSLVSQINTDELTELLPTLEAGMVPKIEACLRAVTEGVPSAHVIDGRVEHCVLVELFTDEGTGTKVVNP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXF_RHIEC
Sequence: MTAFSKHRWRGPVIRRPKTTFGAFLLLFWTWWALLAVFRAFPGIDIYFSQLFFLGTDCDATAAAGSICGGFPYRDSGNFDLLRTIFFRLPYVVAIVMAWKLIECYQQHGATFNAERARKLKVGLGALLIGPVLLVNVILKEHWGRPRPVQTDIFGGALHFVEAGSLAGKCVSNCSFVSGEAASAGWLFCLLLFVPKSLRYALVPPVAAISILTPAMRLSFGAHYLSDVTLGWLSSLVVFAALLALTESQQHQKNSEI
What is the function of this protein?
Probably removes the 4'-phosphate moiety from lipid A species.  Not seen to act on other membrane components, nor does it dephosphorylate the 1-phosphate group of lipid A and/or lipid A precursors.
What are the official names of this protein?
Lipid A 4'-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the lipid A LpxF 4'-phosphatase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCIB_MARMS
Sequence: MKILFDFLPIVIFFVVYKMTGNIIIATAILIPATIIQVGFTWFKNRTIEKMHLVSLALVVLLGGATVLLGDGDFIKWKPTIVNGLFAIAFLGSQFIGDKNIIQRMMGDKLDLPFKVWRTLNLAWVGFFIVSGVTNLYVAFSYSEEIWVDFKLFGLLGMTIVFIILQGIYLSSHLQNKE
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_ECOBW
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: IF2_MESH7
Sequence: MKKSQKRISNVSEIKAQLKTVETKVHNGVFLFSGIMTIAELAQKINVSVNQIITYFFHQAKMYNLNHSLSEDEIAEICLEFGLDFKKEVQIDASNFMEEVSILDQDKDLSPRPPIITVMGHVDHGKTTLLDYIRKTNIAKNEKGGITQHTGAYQVVFQGHIINFIDTPGHEAFTQMRARGAKVTDIIVLVVAADDGVMPQTKEAINHAAAANVPIIVFVNKMDKPNKDVDRIKNELSALNIVTEEWGGSNIFVYGSALTGQGIDTLFSSILLLAEILELKANKNRYPIGTVIEAKLHHNKGTIATLMVQNGTLMVRDFIVAGYQYGRIRSLENTNGQPIKFAPPGTPVIVTGLNYVPEAGDKFFGFHEEKFAKQLALEKKQSEKISKTKVQTKQQTKEKTLNIIVKADVAGIAQALHSTIEKLASKQVHIHILHSGVGIVNKADILLAQTSNSIIYAFNLQIPAAIKAQAKQAQVEIREHTIIYKIVDEIKKQVRGMREIRYELQQIGTAKIIAKFWFSKVGSIAGCSVLSGKFVENCKIELWRNSKLIHSGKIESLQRDKNPVKEVQVGNEFGTHIYKFNDIEIGDELKAFLDVEIEE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_STRP2
Sequence: MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSYFRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFIKITNERYPRLIITRQVKKDGSLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCFYYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGQDDKIIDDLKSKMAVAAQSMEFERAAEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNLFPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKKQLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGTSPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLIVIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEFFLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSLTKIKEASVDEIVEVGVPRVVAEAVQRKLNPQGEALSQVAEERVDYQTEGNHNEP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7A_DROME
Sequence: MVVKKPRPKKKPVTKKVAPAPLAVKKPVVKKVVNQLFEKRPKNFGIGQNVQPKRDLSRFVRWPKYIRVQRQKAVLQKRLKVPPPIHQFSQTLDKTTAVKLFKLLEKYRPESPLAKKLRLKKIAEAKAKGKDVEPKKKPSYVSAGTNTVTKLIEQKKAQLVVIAHDVDPLELVLFLPALCRKMGVPYCIVKGKARLGRLVRRKTCTTLALTTVDNNDKANFGKVLEAVKTNFNERHEEIRRHWGGGILGSKSLARISKLERAKARELAQKQG
What are the official names of this protein?
60S ribosomal protein L7a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
Protein: PHOQ_SALPA
Sequence: MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
What is the function of this protein?
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides.  In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG).  In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PAG and may lead to expression of some PRG (By similarity).
What are the official names of this protein?
Virulence sensor histidine kinase PhoQ, Sensor histidine protein kinase/phosphatase PhoQ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASSY_BUCBP
Sequence: MRNKNIKKVVLAYSGGLDTSAIIPWIKENYSSEVIAFVANVGQNQADLKDIEYKALKSGASQCIIKDLREEFIRDYVYPVLKSGALYEENYLLGTALARPIIAKSQVDLALKLKADGVCHGATGKGNDQVRFETAYVGLAPELKIIAPWREWSFKSRGELLSYLKEKNVKTTASIEKIYSKDENAWHVSTEGGVLEDLWNKPNQDCWTWTNDPKDAPNVPEIISIKIKNGSVIAVNNEFLSPFKCLEKLNLVGIKHGIGRIDVVENRLVGMKSRACYETPGGTILVNALRSLEQLVLDRDSYKWRQQIALEMSYVIYNGNWFSPFRKSLQAAATELATEIDGEVILELYKGTVTAIRKFSPNSLYSKEFATFDQDEVYRQSDADGFIKLYSLPSKIRAINKCMNKALMK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_METPB
Sequence: MDSIETHAKQLGRQTPLPASPEEAQLDRVPNPHADTDYLARFTVPEFTSLCPVTGQPDFATLVIDYVPDRWLVESKSLKLYLAAFRNHGAFHEDCTVGIGRRLADLLEPRWLRIGGYWYPRGGIPIDVFWQTGEPLKSVWLPDQGVAPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_BORBZ
Sequence: MLLDEIKNLNFLIMGLGLNGGGVALSRFLLKRGAKLVITDLKSETELALSIDALRDFEDQIRYVLGKHDVNDFKNADIVVKNPGVKPNNKYLKFAKRIETDISLFLMFNKNPIVAVTGTKGKSTLVSLLYQALKEKYPGVKLGGNIGVSPLSFFDQLDGKSPLILELSSWQLQSLENFNPIISIITNVYNDHQNYYLNFDDYIIDKSKIFVNQTSGIVIIQDQAYCKYFSKFKSKVRVILFSEFNPCDFDQDIFYCNEGKVYFNGNLIGSFSNSRAVFIIPKVITFFVSYYLNIDLNRTGQILSNFKGIEHRLEFVKSVQNVMFYNDTASTIPESTVLSVKSLKTKDNRINLIVGGTDKELDFLSFSKIADIVRTWILIRGSATVKIIKILEKSSIQYFLFDSLRDAVNYAFKISSPGDIVLFSPASASFELFNNEFDRGLQFKNLVNNLG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_STAES
Sequence: MNITLGYIDPVAFSLGPIQVRWYGIIIACGILLGYFIAQAALKQVGLHKDTLIDIIFYSAIVGFIVARIYFVTFQWPYYMNHLSEIPKIWHGGIAIHGGLIGGLISGIIVCKIKNLHPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEHLHLPDFIIRNMYIEGQYYHPTFLYESIWDVIGFVILITLRKRLKLGETFFGYLIWYSVGRFFVEAMRTDSLMLTSHIRVAQLVSVVLILISVIFVIYRRVKYQPIKYENSGPLTWPIKKAK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPF_SPIOL
Sequence: MKNVTDSFVFLGHWPSAGSFGFNTDILATNLINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELRGKAIEQLEKARARLKKVEMDADQFRVNGYSEIEREKMNLINSTYKTLEQFENYKNETIQFEQQKAINQVRQRVFQQALQGALGTLNSCLNNELHLRTINANIGMFGAMNEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SYI_PSEAB
Sequence: MTDYKATLNLPETAFPMKAGLPQREPETLKFWNDIGLYQKLRAIGGDRPKFVLHDGPPYANGSIHIGHAVNKILKDIIVRSKTLAGYDAPYVPGWDCHGLPIEHKVETTHGKNLPADKTRELCREYAAEQIEGQKADFIRLGVLGEWDNPYKTMNFANEANEIRALAEMVKQDFVFKGLKPVNWCFDCGSALAEAEVEYADKKSPTIDVGFPVADADKLAAAFGLAALDKPAQIVIWTTTPWTIPANQALNVHPEIDYALVDAGDRYLVLAEALVESCLARYQREGKVVATAKGEALELINFRHPFYERLSPVYLADYVALDAGTGIVHSSPAYGEDDFYTCKRYGMSNDDILSPVQSNGVYVDSLPFFGGQFIWKANPNVVAKLEEVGSLLAHETINHSYMHCWRHKTPLIYRATAQWFVGMDKQPRQGASLRERALEAITQTEFVPGWGQARLHGMIAGRPDWCISRQRNWGVPIPFFLHKASGELHPRTVELMEEVAQRVEKEGIEAWFKLDAAELLGEEAAQYDKINDTLDVWFDSGTTHWHVLRGSHRIGHASGPVADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRQLLTHGFTVDESGRKMSKSLGNTVVPQTVIDTLGADILRLWVASTDYSGEIAVSQQILQRSADAYRRIRNTTRFLLSNLNGFDAATDLLPPQEMLALDRWAVDRALLLQREIEEAYREYRFWNVYSKVHNFCVQELGGFYLDIIKDRQYTTGANSVARRSCQTALFHIAEALVRWIAPILAFTAEEVWKFLPGERAESVMLATWYDGLSELPADVTLNRQYWEQVMAVKAAVNKELENQRAAKAVGGNLQAEVTLYAEDALQAQLAKLGNELRFVLITSTATLAPLSAAPADAVDSEVAGLKLKVVKSTHAKCGRCWHHREDVGQHAAHPDLCGRCIENIEGSGEVRHYA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENTC3_STAAU
Sequence: MYKRLFISRVILIFALILVISTPNVLAESQPDPMPDDLHKSSEFTGTMGNMKYLYDDHYVSATKVKSVDKFLAHDLIYNISDKKLKNYDKVKTELLNEDLAKKYKDEVVDVYGSNYYVNCYFSSKDNVGKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELDIKARNFLINKKNLYEFNSSPYETGYIKFIENNGNTFWYDMMPAPGDKFDQSKYLMMYNDNKTVDSKSVKIEVHLTTKNG
What is the function of this protein?
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules.  In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:10229190, PubMed:28849041).  Causes also the intoxication staphylococcal food poisoning syndrome (By similarity).
What are the official names of this protein?
Enterotoxin type C-3, SEC3.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT4_RAT
Sequence: MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEKRDLNGNFPKTNPKAGSSSDLENVTPKLFPETEKEAVSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG
What is the function of this protein?
Synaptotagmin family member which does not bind Ca(2+) (PubMed:7993622).  Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A.  Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604).  Plays a role in dendrite formation by melanocytes (By similarity).
What are the official names of this protein?
Synaptotagmin-4, Synaptotagmin IV, SytIV.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
Protein: RL13_THEP1
Sequence: MARYFPVQKTTMIKPEEVERKWYVVDASGKVLGRLATRIAKILMGKHKPNYTPHVDTGDYVIVVNADKVVLTGKKLDQKVYYWHSGYPGGLKSLTARQMLEKHPERLIWLAVKRMLPKNRKGRKMLKRLKVYASPEHPHQAQKPEPIEL
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: DLTC_LISMH
Sequence: MAFRENVLEILEEITETDEVVQNTNIKLFDEGLLDSMATVQLLIEIEERLDITVPVSEFDRDEWATPEMIITQLEALK
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_STRS7
Sequence: MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGVSEDIRVKDLTSDQEDAIRREVDTIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SHSA5_RAT
Sequence: MGFGATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAPSYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQSTGPPAYHETLAGASQPPYNPAYMDPPKAVP
What is the function of this protein?
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
What are the official names of this protein?
Protein shisa-5, Scotin.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane.
Protein: KYNB_DEIGD
Sequence: MIDISRQLTPSHPNWPGDAPFRVKPGARIAQGDSVNTGELCTSTHTGTHVDAPWHYSETGARLEEVELNRYVGRCRVVTVRAEGGLIPAAALAGLPKRLPPRLLLHTGQPAHWTEFPEDFAALDPALIREAARRGVRLIGTDSPSVDPLTSKTLDAHHACLETDTLILEGLNLAEVPDGEYDLVCLPLPLAEVDGAPARAILLPAGTLPEGEG
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.