PharMolix/UniProtQA huggingface dataset:
Protein: RIMP_YERPY
Sequence: MSTLEQKLTEIISAPVEALGYELVGIEFIRGRQSTLRIYIDSDDGITVDACADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPMFTAEHYTRYLGEEVTLVLRMAMQNRRKWQGIIKAVDGEMITVTVDGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPEC_ECOLI
Sequence: MFRSLFLAAALMAFTPLAANAGEITLLPSIKLQIGDRDHYGNYWDGGHWRDRDYWHRNYEWRKNRWWRHDNGYHRGWDKRKAYERGYREGWRDRDDHRGKGRGHGHRH
What are the official names of this protein?
Uncharacterized protein YpeC.
What is the protein family that this protein belongs to?
To E.coli YaaX.
Protein: CNIH2_ARATH
Sequence: MRGVTETDKLANGIFHLVCLADLEFDYINPYDSASRINSVVLPEFIVQGVLCVFYLLTGHWFMTLLCLPYLYYNFHLYSKRQHLVDVTEIFNLLNWEKKKRLFKLAYIVLNLFLTIFWMIYSALDDYED
What are the official names of this protein?
Probable protein cornichon homolog 2.
What is the protein family that this protein belongs to?
Belongs to the cornichon family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FIS_CITK8
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: S1PBP_XENTR
Sequence: MKAAYDCRATKRACSDRKVLILGTNWANPQSGTMEKITISIVNDKATGNKRNIEEEADESPPPKKLRSAVFLCSTPSSAPHCSRDVDVFDEFDDTILERSEDESDSPLHMTLVQIEELLEGDSDYAAEPPGWEEESDTVLQELAVPNADGSQRNIVEFRNLNSPLVEEQSDSSHTLTEETVCSQDTSNYAAMAPSPCWSSISTAEQNGEAGDNVLSVCPITSPVLHKNEVNRGSVQDCSEVCNDSDICSTLSSSHLPGDLKVVDEISEDSDIPFDGDIDELLTLSPGDTTSEDEDNKITSESTPASSELESVPLVHSHTEAIYKTPSSLQCPVTFTASTDPSNLSQLSVSSVTAINGQNNSNKVPLPPSDTAPGPQLPADPCSQSSKVLKVEPKENKVIKETGFEQGEKSCAAPLDHTVKENLGQTSKEQVVVSIGCKKKVKPSQLQQKKLGTLPTKPQAACRPQISNAELEKNRNIYRDRVMMHLEVHNIPGEPNYELATLLNETSRENPTWQHPSDYTRRNYYVRKQPVPCSLNDWVMRNGGPAIERFHGLPCTFQRSPMPGVLPTGPS
What are the official names of this protein?
S100P-binding protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: KPBB_DROME
Sequence: MRDVPKSLGLSVTTPGGSSGAPDSGRHNSLEEINLDQFLKTSNYEDTVKQLDIYYGIVKRQLLRYQSPITGLFPVMSTDQVVGSVRDSVYCASAVWSLYQAYRRIDDDRGKSYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCVSLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIGMAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAFASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFIAMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPDGDGSYMRAPSQSLFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQGTATDLVVQIVLIAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSKVYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHMRDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEHLDFMNQSDLTDNENAFSQINHEYIGYQSLTDVPKALTYVEEKISVAHFDTKPTPDIINALRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVDSISPFITTVLVNGKELTVGIIGQKETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGRLIATNPSMFRGILKIRIGWVLEAMRIYLQISGQQSIDVDNLSPFQVRILLQKVLTVSEWAVEEKLTTLQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIVATILNRNPELHFKQALDLDGILAEAFAMYCKDNNIQHQPKPEHEQTKNEDLKAFYSLPYSETTGYLARAAVNKVLQGGIFSTNEEDVQLDGDRLHDDNCKVS
What is the function of this protein?
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.  The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity).
What are the official names of this protein?
Probable phosphorylase b kinase regulatory subunit beta, Phosphorylase kinase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the phosphorylase b kinase regulatory chain family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RL5_LACDA
Sequence: MANSFATKYNEEIVPALTKKFNYTSSMQVPKIDKIVLNMGVGDAVANAKNLDEAVEELTLISGQKPMITKAKKSIANFRLREGMSIGAKVTLRGDRMYDFLSKLINVSLPRVRDFRGVSTRSFDGRGNYTLGVKEQLIFPEIDFDKVNRTRGLDIVIVTTAQTDEEARELLTQFGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CP1A2_CANLF
Sequence: MALSQMATGLLLASTIFCLILWVVKAWQPRLPKGLKSPPGPWGWPLLGNVLTLGKSPHLALSRLSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGDDFKGRPDLYSLSLITDSQSMSFSPDSGPVWAAGRRLAQNALNTFSIASDPASSCSCYLEEHVSKEAEALLSRLQEQMAEVGRFDPYNQVLLSVANVIGAMCFGHHFSQRSEEMLPLLMSSSDFVETVSSGNPLDFFPILQYMPNSALQRFKNFNQTFVQSLQKIVQEHYQDFDERSVQDITGALLKHNEKSSRASDGHIPQEKIVNLINDIFGAGFDTVTTAISWSLMYLVANPEIQRQIQKELDTVIGRARQPRLSDRPQLPLMEAFILEIFRHTSFVPFTIPHSTTKDTTLKGFYIPKECCVFINQWQVNHDQQVWGDPFAFRPERFLTADGTTINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQRLEFSVPAGVKVDLTPIYGLTMKHTRCEHVQARPRFSIK
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2.  Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis.  May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer.  Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).  Plays a role in the oxidative metabolism of xenobiotics.  Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.  Metabolizes caffeine via N3-demethylation.
What are the official names of this protein?
Cytochrome P450 1A2, CYPIA2, Cholesterol 25-hydroxylase, Cytochrome P450-D2, DAH2, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: KDSA_SALEP
Sequence: MKQKVVNIGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDRGANFGYDNLVVDMLGFSVMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVKSFDELDTEN
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_BACHK
Sequence: MNEMTHRTKTRPVKVGNLTIGGNNELIIQSMTTTKTHDVEATVAEIKRLEEAGCQVVRVAVPDERAANAIADIKKQINIPLVADIHFDYRLALKAIEGGIDKVRINPGNIGRRHKVEAVVNAAKERGIPIRIGVNAGSLERHILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAARAFDYPLHLGITESGTLFAGTVKSAAGLGAILNKGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISTLQVPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGQVVRKVPEEIMVEELKKEIDVIAAEMAAEREKEKETQEQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HIS6_CORGL
Sequence: MGVAIRVIPCLDVDNGRVVKGVNFENLRDAGDPVELAKRYDEEGADELTFLDVTASKHGRGTMLDVVRRTADQVFIPLTVGGGVRSEEDVDQLLRAGADKVSVNTSAIARPELLSELSKRFGAQCIVLSVDARRVPEGGTPQPSGFEVTTHGGSKSAELDAIEWAKRGEELGVGEILLNSMDGDGTKNGFDLELLEKVRAAVSIPVIASGGAGKAEHFPPAVAAGANAVLAATIFHFREVTIAEVKGAIKDAGFEVRK
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL1A2_HUMAN
Sequence: MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
What is the function of this protein?
Converts retinaldehyde to retinoic acid (PubMed:29240402, PubMed:33565183).  Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal.  Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal.  Displays complete lack of activity with citral (By similarity).
What are the official names of this protein?
Retinal dehydrogenase 2, RALDH 2, RalDH2, Aldehyde dehydrogenase family 1 member A2, Retinaldehyde-specific dehydrogenase type 2, RALDH(II).
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_THEKO
Sequence: MGEFDREELTIIRKFEHIEHCLKRNVQAHVTNGFEDVHFVHMSLPEIDKDEIDLSVEFLGRKFDYPIFIAGMTGGTKGSQLAGRINKTLAKAAQELNIPMGVGSQRAMIRKPETWESYYVRDVAPDVFLVGNLGAPQFSETIRERYGLEEALKAVETIQADALAIHMNPLQESVQPEGDTQYRGVLKALAELKAEFPYPIIAKETGAGVSMEVAVRLESIGIDAIDVGGLGGTSWSGVEYYRAKDEIGKDLALRFWDWGIKTAISVAEVRYATELPIIATGGMRDGIAMAKALAMGATFAGVALPLLKPAVKGDVEGVIKILRRYIEEIRNAMFLVGARNVEELRKVPLVITGFTREWLEQRIDLPSYLRNRGI
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I12R2_HUMAN
Sequence: MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML
What is the function of this protein?
Receptor for interleukin-12.  This subunit is the signaling component coupling to the JAK2/STAT4 pathway.  Promotes the proliferation of T-cells as well as NK cells.  Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
What are the official names of this protein?
Interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FMA2_DICNO
Sequence: MKSLQKGFTLIELMIVVAIIGILAAFAIPAYNDYIARTQVSEGVSLADGLKIRIADNLQDGDCVTKGDSSTGEVGNEDKGKYALATILGTPAQNLSELKAEDPNGCQVKIEYGKGTSGGSVSALINNTELVLAQLANGSYKKESSTVKDKFLPKALKENK
What is the function of this protein?
Major component of the type IV fimbriae that plays an essential role in twitching motility, natural transformation, and protease secretion.
What are the official names of this protein?
Type IV major fimbrial protein FimA, Pilin, Serogroup C2.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: HSCB_VIBC3
Sequence: MNYFELFGLPIQFELDGSLLSSQFRALQKRFHPDNFATASERDRLMAVQQAAQINDAYQTLKDPLRRAEYLLSLQGIEMNAEQQTLQDPMFLMEQMELREELESVTACADPEAALVAFDTKVTAMQRHYLAQLQGQLAQSEWLAAADQIRKLKFIAKLKNEVERVEDQLLG
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: CHIQ_TOBAC
Sequence: MEFSGSPMALFCCVFFLFLTGSLAQGIGSIVTSDLFNEMLKNRNDGRCPANGFYTYDAFIAAANSFPGFGTTGDDTARRKEIAAFFGQTSHETTGGSLSAEPFTGGYCFVRQNDQSDRYYGRGPIQLTNRNNYEKAGTAIGQELVNNPDLVATDATISFKTAIWFWMTPQDNKPSSHDVIIGRWTPSAADQAANRVPGYGVITNIINGGIECGIGRNDAVEDRIGYYRRYCGMLNVAPGENLDCYNQRNFGQG
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Acidic endochitinase Q, Pathogenesis-related protein Q, PR-Q.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Extracellular fluid from leaves.
Protein: RGA_DROME
Sequence: MANLNFQQPPRSIANAALAGRTTGGFGGSSLAGHVTPTSGMFQTDFANSYPGTANYGQAPQQQQQQQQQPQLSPNRNAQLSVGGPAISSGNRNANLFGQRQFVERRAMQGLGSGPMSNMGNFMQTGRGGYGTGGGGGGPLNNFHVFGGGGGSDTSTPALLDPTEFPSLTNARGQNDQTLPQSNPLQPPGSKPYGNFFTSFGMVKQPTSEQSEFTMSNEDFPALPGTQNSDGTTNAVGSVAGTGGSGGASTENHLDGTEKPMNSIVVSGSASGSSGSNVGVVGGNGLGAVGSGIGGLAVGGGGGAGSSGGGGVGGNAASGVVGGSHVGLVGSNSGIGGVNSVPNSNAMMGVGGGLGSGSGSSGSGAGGEHLNDNSSNDKLVKSGVQTSPDGKVTNIPATMVNNQFGMVGLLTFIRAAETDPNLVTLSLGTDLTGLGLNLNSQESLHTTFAGPFVAQPCRAQDVEFNVPPEYLINFAIRDKLTAPVLKKLQEDLLFFLFYTNIGDMMQLMAAAELHSREWRYHVEEKIWITRIPGIDQYEKNGTKERGTFYYFDAQSWKRLSKVFQIDPEKLDKCPNISAFMNGQSV
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20504953, PubMed:23303381).  Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23303381).  Essential for viability (PubMed:9475742).  Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes (PubMed:9475742).  Plays a role in germline stem cell differentiation in the ovaries (PubMed:29887366).
What are the official names of this protein?
Regulator of gene activity, Protein regena, CCR4-NOT transcription complex subunit 2 homolog, CNOT2, Not2.
What is the protein family that this protein belongs to?
Belongs to the CNOT2/3/5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGO_YERPP
Sequence: MLAVYLHGFILSAAMILPLGPQNVFVMNQGIKRQHHLMSASLCALSDIILICAGIFGGSALLSRSPLLLALVTWGGVAFLMWYGWGALMAAWRGDGVASSATSVTQGRWRILVTLLAVTWLNPHVYLDTFVVLGSLGGQLLPDIRPWFALGAVTASIVWFFALALLAAWLSPWLNRPVAQRIINLFVGGVMGFIAFQLARQGFGL
What is the function of this protein?
Involved in the export of arginine.  Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
What are the official names of this protein?
Arginine exporter protein ArgO.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPIP2_HUMAN
Sequence: MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ
What is the function of this protein?
Binds to F-actin.  May be involved in regulation of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Proline-serine-threonine phosphatase-interacting protein 2, PEST phosphatase-interacting protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: YIDC_CHLP8
Sequence: MDRNSVIGFSLIAVIMIVWLQFMKPEQKTMLDPVPPSREMVQKDAAENAPASAAPETAAESLGSFAKASTGTEQIITVDNDLFTAELSSKGATLKSMVLKKHLDVNGKPFNLISEKNKGALSMLFLSNDGKRIDTRDLYFRSLDTKKSETVTGKEKLSVSFVLDVDASRSMQVTYTFTGDSYVIDYDLKLNGFGSTLAGNEYQLDWDGGLVYSEKDTADESHNAISSAYLGGGLLKLDAKDSKKRYQEEESGKAEWVAVRNKYFVAAMIPERETEGVFLQGTKKDGVDFENYTAALKMMIPAGQNSVTDRYRLYVGPLDYNTVRSLHVDLEKIMDFGWDWLTRPFAEYLILPIFNWMNKYVTNYGLIIIIFAFLIKTVTWPLSLASTKSMKKMSALQPMMKEIQEKYKNDPAKLQSELGRIYKEAGVNPLGGCLPTVIQMPLLFAMFYVFRSSIQLRQHGFLWVKDLSVPDSILDFGFKLPLYGDHIALMPILMAVTVFFQQKITPTTQTNDQMKIMIWMFPAMMLLFFNNMPSGLALYYLMFNVFSIAQQAYINATVSDEDKAAAAMQVAASASPSKGAKKGGKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EIF3G_DANRE
Sequence: MPSIEFDDSKPSWADQVEEEGDEGSLPSPKETVKGNIKTVTEYKIDDDGQKFKIIRTFKIETRKASKAVARRKNWKKFGNSEYDAPGPNVATTTVSDDVFMTFISSKEDLNAQDQDEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKAAEPEPAQPVQNKTGKYVPPSLRDGGTRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKNTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSNN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G, eIF3g, Eukaryotic translation initiation factor 3 RNA-binding subunit, eIF-3 RNA-binding subunit, Eukaryotic translation initiation factor 3 subunit 4.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_STRM5
Sequence: MTNPFDSAGSKAPPKPFTVSEGRREVRSFVLRQGRFTPAQQRAFDERWPRFGIDYNGQPRDLDATFGRPAHKVLEIGFGNGAAMRFAAQHDPSRDYIGIEVHAPGVGRLLNALADDNADHVRLYHHDAVEVLQNEIADGALDEVRIYFPDPWHKKRHNKRRLLQPAFAELIVRKLRPGGRLHCATDWEDYAEQMWDVLDATAGLVNRAGPRGSVPRPDWRPQTHFETRGQKLGHGVWDLLYDRT
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MUTS_LACLS
Sequence: MAEKISPGMQQYLDIKQDYPDAFLLFRMGDFYELFYEDAVNAAQILELTLTSRNKNSENPIPMAGVPHHAATEYIDKLVDLGYKVAVAEQMEDPKKAVGIVKRAVTQVITPGTTIDTANSVDNNFLVAIDFKAKRYALSYMDLSTGEFKVTELSEFSAVVGGIASLKAREIVVGFPLDEAQVKVFERQMNLLISEQFEIPENLLIELSGLTALENQAASKLLAYVKETQMRDLSHLQEVEHYEIKDFLQLDFATKSSLELTANKRENKKHGTLYWLLDETKTAMGTRMLRSWIDRPLVSNSAIQKRMEIVQVFLDHFFERSDLIEALKGVYDLERLASRVSFGKAVPVDFLQLANSLSNVPAIKNILEVLDETSLNELRSQLDEIPELSGLINSAISENASRTITEGGIIKKGYNVQLDKYREALENGTSWIAKLEADEKAKTGISTLRIDYNRKDGYYFHITQSQLNSVPEHFYRKATLKNSERFGSQELTEIEEIMLEAREKSSSLEYDLFMGLRAETEQYIGRLQALAKTIAEIDCLQSLSVVAEKQGYIRPTLTEGSRIVEIKGGRHAVVEAVMGAQEYVPNDIELPEQTDIQLITGPNMSGKSTYMRQFALTVIMAQIGSFVPAKTANLPIFDAIFTRIGASDNLISGESTFMVEMSEANHAIQKATSRSLIIFDELGRGTATYDGMALAQAIIEYVHEYIGAKTLFATHYHELTDLDKELDHLDNVHVATLEQNGNVTFLHKITDGPADKSYGIHVAKIAGLPQTLLERADLILQKLENKPLPAKKIADEQEQLSLFDFAENSSEIIEKIKGQNVDNMTAREALNFLWELKDSL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ATPB_LEUMM
Sequence: MSTGKVVQVIGPVVDIAFEAGQQVPDINNALVIDKGNGQSLTVEVSLALGDGVVRTIAMDSTDGLQRGMGVVDTGNPIEVPVGEATLGRVFNVLGEPVDNNGAIASDVRRSSIHRDAPKYDELTSSTEILETGIKVIDLLAPYVRGGKIGLFGGAGVGKTVLIQELIHNIAQGHNGISVFTGVGERTREGNDMYHEMEESGVLKQTAMVYGQMNEPPGARMRVALTGLTMAENFRDNEGKDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAVYVPADDYTDPAPATTFAHLDATTNLERALTQQGIYPAVDPLASTSSALDPQIVGQEHYEVATEVQRTLQRYRELQDIISILGMDELSDEEKTTVNRARRIQFFLSQPFSVAETFTGINGEYVPVAETVRSFKEILDGKYDDLPEDAFRNVGAIEQVVEKAKTMAQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.