PharMolix/UniProtQA huggingface dataset:
Protein: OVOS_MOUSE
Sequence: MVPTILLSALLLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTLEYDGSSTTIFDQPVDEGNFYACADFKVSQMSSEQLAFVALLVQGNTLKISERRSVAIAAEENATFVQTDTPVHKPGDTVHFRVVTLNIWLKPVDDLYPLITVQDPQSNVIFQWINVTTFRNITQLSFQLTPEPILGDYTIVIKTQSGTTVMDHFTVNRDVLPKFEVELTAPETITIADSQFQMVTCAKYTYGQPVQGKAQIKVCRELFSPAHCESNENEICEQFTVQLKDGCASHIINTKVFQLDRSGLFMTLNVNEVVTESGTGVQMSKTHSVFITSVLGTVSFENMDPFYRRGITYFGTLKFSGPNNTPLVDKLLQLELDGKPVGNYTTDENGEARFSINTSEIFGAQISLKAVYVRPRSCHRSSWLSPEYLDAYFSASRFYSQTSSFTKIILEPKQLPCDQEKMFSVLYSLNPEAYKEASDVTFFYLVMVRGGISRSGQKQVRVQAWNGNFSFPISINADLAPSADLFVYTLHPSGEIVADNVRLQIEKCFKNKVSINFSRDKDLPGSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEMTPESVYFTLPYIHQYGYFYNGLNLDDQQAEPCIPQKDLFYNGLYYTPTGNIWDGDLSNLLSNMGLKIFTNLHYRKPEVCSSQENQPLLRTFDHPNERIMMYGGGAPPSSAFHDSVDSISHAKVAIKETVRTNFPRTWIWNLVSVDSSGTANVSFLVPDTITQWEASAFCVNGNAGFGISPKVSLQISQPFFVEVTSPFSVVRSEQSDMVVTVFNYLTTCVEISVQLEASENYEASINTQRNTDSEVLQAGEQKTYVWTIIPKTLGKVNVTVVATSKQSRACPNDASKEQDVHWKDTVVKTMLVEAEGIEKEATQSFLICPKGTKASKQTLLELPSNVVEGSVRSFVTIVGDILGVAMQNLESLLQMPYGCGEQNIAQLASDVYILDYLKATDQLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQSNQEGSTWLSALSFKTVEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRRDEKHVDTAQEGREGDQEDIALTAYVVGVFLEVGLNASFPALRNGLYCLEEAFSNGVTNGYTQAILAYVFALAGKEQQAKSLLSILDKSATKTNNMIYWERDEKPETDNSPSFIPSALSGETEKTCYVLLAVLSQDTQDLDYASKIVQWLAQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQNTITLSSEESEEVFYVNRNKRLLVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPLPKEASGFSLSVKTGKSNSSDEFQTKFELTVTLTYTGARESSVTVLVDVKMLSGFTPVVSSTEELKFNSQVTKTDIKNGHVLFYLENVPKEATSLTFSIEQTNHVANIQPAPVTVYSYEKGEYAFDSYNINSISDSQ
What is the function of this protein?
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.
What are the official names of this protein?
Ovostatin homolog.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL19_MYCSJ
Sequence: MNTLDFVDQSSLRDDIPAFGPGDTVNVHVKVIEGSKERIQVFKGVVIRRQGGGIRETFTVRKESYGVGVERTFPVHSPNIDHIDVVTRGDVRRAKLYYLRELRGKKAKIKEKR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: FTHS_STAAW
Sequence: MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKVQGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: GLO2_VIBPA
Sequence: MLEIKSIPAFNDNYIWLIQNSDKRCAVVDPGDAQPVLDYLQANELTLEAILVTHHHNDHIGGVPDLVRAFPHVTVVGPKAEPIPTLTTPMEEGDKLELFGEIFLVLGLPGHTLGHIGYVGDSKLFCGDVLFSAGCGRIFEGTPEQMFESLSKIAALPEETQVFCAHEYTASNVAFALAVEPDNEQLRQYRDDVNRLRALNIPTLPTTLRKEKWINPFLRTTNPDVVKSVANRIKNSDPCSVFTALREWKNEF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: GUR3_CAEEL
Sequence: MTITASNTLEFKWTSPRSSRSSFRTTTDAEQKISIDMSNTYCDQVLGPLYSYMMVLGLNHTHSSARNTMFKWPLTIYNYLTLAILTAATIRRISQIKQKSATNEEKDAAFHVLNPTFVLTLCHALLMFSGLAAGFLLLKLQKQREKMYHVLDQGLGRNRNEEHDSHHFKLNKLFISISFSFAAALSFVQIATKMRYLDLPDTPDLINRKIYFVILEGYVIFIASSCISLVAILFFQLCRILQFSIGQLIEEMVPKEKEECPLPEQSLQQIHDVQIHYQEISNAKLYIEQNFSFSLFYTYGCCIPLTCLLGYIAFRNGIQADMAETFSVAIWLTNTMLALMLFSIPAFMIAEEGDKLLTASFKMYHETLCEERDLLVLSQMSFLSFQMHATKLTLTAGNFFMMNRKIMISLFSAIFTYFLILVQFDAEKERAGECNNQSRVLIVQPPV
What is the function of this protein?
Chemoreceptor involved in light-induced avoidance behavior (PubMed:25640076).  Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076).  Involved in circadian rhythms, probably by acting as a light sensor (PubMed:27849618).  In contrast to lite-1, does not act as a photoreceptor (PubMed:27863243).
What are the official names of this protein?
Gustatory receptor family protein 3.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AKH_DAUCA
Sequence: SLSSAISPSSYAAIAAAYSARTPIFNKKKTAAVLSPLSLFHQSPSLSKTGIFLHRGRKESSSKFYIAASVTTAVPSLDDSVEKVHLPRGAMWSIHKFGGTCVGSSERIRNVAEIVVEDDSERKLVVVSAMSKVTDMMYDLIYKAQSRDDSYESALDAVMEKHKLTAFDLLDEDDLARFLTRLQHDVITLKAMLRAIYIAGHATESFSDFVVGHGELWSAQLLSFVIRKNGGDCNWMDTRDVLVVNPAGSNQVDPDYLESEKRLEKWFSSNQCQTIVATGFIASTPQNIPTTLKRDGSDFSAAIMGALLRAGQVTIWTDVNGVYSADPRKVSEAVVLKTLSYQEAWEMSYFGANVLHPRTINPVMRYDIPIVIRNIFNLSAPGTMICRESVGETEDGLKLESHVKGFATIDNLALINVEGTGMAGVPGTATAIFGAVKDVGANVIMISQASSEHSICFAVPESEVKAVAKALEARFRQALDAGRLSQVANNPNCSILATVGQKMASTPGVSATLFNALAKANINVRAIAQGCTEYNITVVLSREDCVRALKAVHSRFYLSRTTIAVGIVGPGLIGATLLDQLRDQAAILKENSKIDLRVMGITGSRTMLLSETGIDLSRWREVQKEKGQTAGLEKFVQHVRGNHFIPSTVIVDCTADSEVASHYHDWLCRGIHVITPNKKANSGPLDQYLKLRALQRRSYTHYFYEATVVAGLPIITTLQGLLETGDKILRIEGIFSGTLSYIFNNFKSTTPFSEVVSEAKAAGYTEPDPRDDLAGTDVARKVIILARGSGLKLELSDIPVQSLVPEPLRGIASAEEFLLQLPQFDSDMTRKREDAENAGEVLRYVGVVDAVNQKGVVELKRYKKEHPFAQLSGSDNINAFTTERYNKQPPIIRGPGAGAEVTAGGVFSDILRLASYLGAPS
What are the official names of this protein?
Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic, AK-HD, AK-HSDH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the homoserine dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FMT_STRMU
Sequence: MTKLIFMGTPDFSATVLKGLLEDSHYHVLAVVTQPDRAVGRKKEIKMTPVKQLALEHGLKVYQPEKLSGSSEMVELMNLGADGIVTAAFGQFLPMILINSVDFAVNVHASLLPKYRGGAPIHYAIINGDKKAGVTIMEMVKEMDAGDMIAKASTPITDADDVGTMFEKLAIIGRDLLLQTLPGYLSGKIEPQAQDDSQATFSPNISSQEEKIDWSKSARDIFNQVRGMNPWPVAHTLLDGKRFKIYAVEVVNGAGNPGEIIEKTKKALIVAANQDALSLKLVQPAGKPKMSITDFLNGLGQKLKVGDYFGK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: Y1297_ARCFU
Sequence: MSDKKGEEITLRVAEAFYRDVGRGVARIDPAVMEKYGLQSGDIIEIIGKSTVPAIVWPSYPEDRGTGIIRIDGSIRSNAGVGIDDKVRIRKVTAKPAEKVTLAPTEPVRLMGGEAYLLRLLEGRPVIKGQKIRVEVFGHTLTFVITATRPSGVVVVTRNTAIELKEKPAEEVKRAVPDVTYEDIGGLKRELRLVREMIELPLKHPELFQRLGIEPPKGVLLYGPPGTGKTLIAKAVANEVDAHFIPISGPEIMSKYYGESEQRLREIFEEAKENAPSIIFIDEIDSIAPKREEVTGEVERRVVAQLLALMDGLEARGDVIVIAATNRPDAIDPALRRPGRFDREIEIGVPDKEGRKEILEIHTRKMPLAEDVDLEELAELTNGFVGADLEALCKEAAMHALRRVLPEIDIEAEEIPAEVIENLKVTREDFMEALKNIEPSAMREVLVEVPNVKWEDIGGLEHAKQELMEAVEWPLKYPEVFRAANIKPPRGILLFGPPGTGKTLLAKAVANESNANFISVKGPELLSKWVGESEKHVREMFRKARQVAPCVIFFDEIDSLAPRRGGIGDSHVTERVVSQLLTELDGLEELKDVVVIAATNRPDMIDPALLRPGRLERHIYIPPPDKKARVEIFKIHLRGKPLADDVNIEELAEKTEGYSGADIEAVCREAGMLAIRELIKPGMTREEAKEAAKKLKITKKHFEEALKKVRPSLTKEDVEKYEKLIEDFHRMYA
What are the official names of this protein?
Cell division cycle protein 48 homolog AF_1297.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. CDC48 subfamily.
Protein: VPP1_SCHPO
Sequence: MSPSLFRSEEVSLVQLYLPTESARPIMSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYLHSEIDLNGIHVPDHNLPPSYESVLESSTIEDIIERITRLEARVRQLVESSQLLEARYLQQLEFANVLTKADAFFSKSGNTVDPLRNNYETSSIFSGEDDTTAPLIENALELGTTGTFDSEETSPQMNTTLDFVSGIIPTVKFQFLERILWRTLRGNLFIHQVRADDSLIHGAEKNEEKTIFLVIAHGTQILLRIRKISESLGATLFPVEEDAPGRTSQIQQANVSISDLNAVLENTRSALYTELTFIAEHISAWEAVLHKDKTVFQVMNLFNYDQNHKCLIAEGWCPTANLPMVQKTLRNISDLTDSQAPTILNVVHTSEQPPTYFRVNKFTEGFQSIIDSYGIATYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMASVALMFVLYEKTLGAKKDLDEIVGMVFYGRYIVLLMGLFSMYVGFVYNDLFSKPMSIFSSRWVWPVKSEEAIARAVQVGTYPIGIDPTWHSADNNLLFMNSYKMKLSIILGVIHMTFCLFLSLSNYRFFKRKLDIYAVFVPSLIFLEAIFGYLVITIVYKWCIDWKAKDLQPPSLLNMLILMFLSPGTLEDQLYPGQKYLQVGLVIAALICVPWLLIVKPFVLWRRHSNEENKYQSLNSDLPNVDEADALMAVDSQEKQAEPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLWALSLAHNQLSSVLWNMTLANGFRMTGIVGSIFVVILFGFWFIATCVVLVAMEGTSAMLHSLRLHWVEGMSKHFEGEGYAFTPFTFKVTAE
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit a, V-ATPase a subunit, Vacuolar ATPase 91 kDa subunit, Vacuolar proton pump a subunit, Vacuolar proton translocating ATPase subunit a.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase 116 kDa subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: UPPP_KOCRD
Sequence: MNWIEAIILGLVQGLTEFLPVSSSAHLRIVGEFLPHGGDPGAAFTAITQLGTETAVILFFWRDIVRIIKQWALSLTGRVDRKDPDARMGWFIILGSFPIAVLGLLLQDVIETQFRSLWITATMLIVFGLFLAVADHVGKQERHLEDLDVKHAVGYGFAQALALIPGVSRSGGTITAGLLMGYTRAAAARYAFLLAIPAVFSSGLYELYKVLAGKVPAGIYTMGQTAVATVIAFAVGYLIIGWFMHYISERSYSLFVWYRILLGAAVFVLLGTGILTA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCNL1_HUMAN
Sequence: MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
What is the function of this protein?
Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954).  Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859).  Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.  Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483).  Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
What are the official names of this protein?
DCN1-like protein 1, DCNL1, DCUN1 domain-containing protein 1, Defective in cullin neddylation protein 1-like protein 1, Squamous cell carcinoma-related oncogene.
Protein: PNP_PARDP
Sequence: MFDEVKKSIQWGQETLTLETGKVARQADGSVIATLGETSVMANVTFAKEPKPGQDFFPLTVHYQEKYYAAGKIPGGFFKREARPSEKETLTARLIDRPIRPLFVPGFKHEVLVMCTVLSHDLVNDPDIVAMIAASAALTISGVPFMGPIAAARVGFADGEYVLNPEVQDMDHLRLNPEQRLDLVVAGTRDAVMMVESEAYELTEAEMLGAVKFGHEAMQPVIDLIIDLAEAAAKEPFEFASPDYSALYARVKSLGEADMRAAYAIHDKGERRDAIEVAKAKVLAGLSEEELLDPNLGSALKKLESGILRGGIIDGRPRIDGRDNKTVRPIDCEVGFLPRTHGSSLFTRGETQALVVTTLGTGDDEQIIDALHGNSRSNFLLHYNFPPYSVGEVGRVGSPGRREIGHGKLAWRALQAVLPAPTDFPYTIRVVSEITESNGSSSMASVCGGSLSMMDAGVPLKAPVAGVAMGLILEEDGRWAVLTDILGDEDHLGDMDFKVAGTENGITSLQMDIKVAGITPEIMEQALAQAKDGRLHILGEMSKALSEGRREFSAHAPRIETMTIPTDKIREVIGSGGKVIREIVETSGAKVDISDDGTIKIASANADSIKKAYDMIYSIVAEPEEGKIYVGKVVKLVDFGAFVNFFGKRDGLVHVSQIAGKRLNHPNEVLKEGQEVKVKLLGFDDRGKVRLGMKMVDQETGEEIAPEKKEETAEG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_ATRBE
Sequence: MLGDGNEGISTIPGFNQIQFEGFCRFIDQGLTEELYKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKNSRDMQEQTIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWGGRSELEIDRKARIWARVSRKQKISILVLSSAMGLNLREILENVCYPEIFLSFLSDKERKKIGSKENAILEFYQQFACVSGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRRLNLDIPQNNTFLLPRDILAAADHLIGLKFGMGALDDMNHLKNKRIRSVADLLQDQFGLALVRLENVVRGTICGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTASFRIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARIGHWGSLESPFYEISERSTGVRMLYLSPGRDEYYMVAAGNSLALNRDIQEEQVVPARYRQEFLTIAWEQVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQAALDSGALAIAEREGRVVYTNTDKILLAGNGDILSIPLVIYQRSNKNTCMHQKLQVPRGKCIKKGQILADGAATVGGELALGKNVLVAYMPWEGYNSEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPEKVTNEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQVVKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWIQKRGGSSYNPETIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRSVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGNPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRAKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPNPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YEZB_BACSU
Sequence: MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFLLGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK
What are the official names of this protein?
Uncharacterized protein YezB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ2_NOCFA
Sequence: MRWQRLAEEVREHQFRYYVRDAPIISDGEFDALLRELQELEDRHPDLRTPDSPTQLVGGGFATDFTPVDHLERMLSLDNVFDVDELRAWAARVEAETGPDLHYLCEVKIDGVALNLVYERGKLVRAATRGDGRTGEDVTLNARTIEDVPGELSAGGEFPVPELLEVRGEVYLRLADFEALNAAIVAEGKPPYANPRNTAAGSLRQKDPAVTARRRLRMICHGLGRIEGYTPASQFEAYRALSAWGLPVSEHTRRVRGIDAVIERVAYWGEHRHDIEHEIDGQVIKVDETSLQRRLGATSRAPRWAIAYKYPPEEATTKLRAIEVNVGRTGRVTPFAVMEPVVIAGSTVAMATLHNASEVKRKGVLIGDTVTIRKAGDVIPEVLGPVVDARTGAEREFVMPTHCPECGTELAPEKEGDADIRCPNQRSCPAQLRERVYHVAGRSAFDIEALGYEAAIDLLQSGAIGDEGDLFDLDEARLLTTSLFTNKNGSLSANGKRLLENLDAAKDRPLWRVLVGLSIRHVGPTAARALAAEFGSMERIEQASVDELAATDGVGPTIAAAVAEWFTVDWHRAIVAKWRAAGVRMVDERDESIERTLEGLSIVVTGSLQGFSRDGAKEAILARGGKAAGSVSKKTAFVVVGDAPGAKAAKAEELGVPILDEEGFVRLLAEGPAAVAAEEPESG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase 2, Polydeoxyribonucleotide synthase [NAD(+)] 2.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: A70A_DROMA
Sequence: MKTLSLFLVLVCLLGLVQSWEWPWNRKPTKYPIPSPNPRDKWCRLNLGPAWGGRC
What is the function of this protein?
Represses female sexual receptivity and stimulates oviposition.
What are the official names of this protein?
Accessory gland-specific peptide 70A, Paragonial peptide B, Sex peptide, SP.
What are the subcellular locations of this protein?
Secreted.
Protein: SLMA_SALPB
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKNTSTRLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDENLLASQLLAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PAFA_MYCTO
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSETTTMLKVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQREYYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQPPQTTRARLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.  PafA is required to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: CYSI_TOLAT
Sequence: MSEQKLSDNERLKAESNFLRGTIELDLKNDLTGGFTGDNFQLIRLHGMYQQDDRDIRAERAQQKLEPLHNVMLRARMPGGIITPEQWLGIDKFAHDHTMYGSIRLTTRQTFQFHGVLKPNIKMMHQTLNKYGIDSIATAGDVNRNVLCTSNPVESELHQEAYEWAKKISEHLLPKTRAYAEIWLDGEKLGPDEEPILGSTYLPRKFKTTVVIPPHNDIDVHANDLNFVAIAEDGKLVGFNVLVGGGLAMTHGNKETFPRKADDFGFIRKEDTLKFAEAVVTTQRDWGNRVNRQNAKTKYTLERVGVDAFKAEVEKRTGIKFEESRPYVFTSRGDRFGWVEGIDGKQHLTLFIENGRILDFPGKPLKTGLAEIAKIHKGDFRMTANQNLIIAGVPKKDKAKIEKIARAHGLIDDAITEQRKNSMACVALPTCPLAMAEAERFLPAFTTQIEAVMAKHGLADDHVIFRVTGCPNGCGRAMLAEIGLVGKAMDRYNFYIGGNREGTRIPRQYRENITSAEILKEIDALLGRWAKERNENEGFGDFVIRAGIVKPVVDSAKDFYAA
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: RL31_PSEA8
Sequence: MKADIHPTYEAIEATCSCGNVIKTRSTLCKPIHLDVCSECHPFYTGKQKVLDTGGRIDRFKQRFGVFGATK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: GREA_RHOPT
Sequence: MVEKIPMTASGYAALSDELKHRQSVDRPRIIEHIAEARSHGDLSENAEYHAAKEEQSHNEGRINELEDKLARADIIDVSKLSGDTVKFGATVTLIDEDTEKKAVWQIVGEAEADAKKGKISITSPLARALIGKKAGSSVEVVAPGGAKAYEIAKVEWR
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RPOZ_HERAR
Sequence: MARITIEDCLKQIPNRFQLTLCATYRARQLLQGHTPKVDAKDKPTVIALREIAAGHVGIEMLKKVPS
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PA2HI_TRIST
Sequence: MRTLWIMAVLLVVVEGSLVQLGKMIFQETGKNPATSYGLYGCNCGPGGRRKPKDATDRCCFLHKCCYKKLTDCDPIKDSYSYSWVNKAIVCGGDDPHLKEMCECDKAMAICFRENLDTYDKKKKINLKLFCKKTSEQC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:12959640).  It shows myotoxic and weak anticoagulant activities (PubMed:12959640).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog CTs-K49a, svPLA2 homolog, PLA2-III.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL14_THEMA
Sequence: MIQQETYLNVADNSGAKKLRVIRVIGGFHKKYGTVGDIVVCSVREAIPNSDVKKGDVVRAVIVRTKKEIRRNDGTYIRFDDNAAVLIDKFNAPRGTRIFGPVARELREKGFMKIVSLAPEVW
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.