PharMolix/UniProtQA huggingface dataset:
Protein: 5HT2B_RAT
Sequence: MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1505525, PubMed:1331748).  Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:22525520).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:1505525, PubMed:1331748).  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity).  Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity.  Plays a role in the regulation of behavior, including impulsive behavior.  Required for normal proliferation of embryonic cardiac myocytes and normal heart development.  Protects cardiomyocytes against apoptosis.  Plays a role in the adaptation of pulmonary arteries to chronic hypoxia.  Plays a role in vasoconstriction.  Required for normal osteoblast function and proliferation, and for maintaining normal bone density.  Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).  May play a role in the perception of pain (PubMed:22525520).
What are the official names of this protein?
5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, 5-HT-2F, Serotonin receptor 2B, Stomach fundus serotonin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Synapse, synaptosome.
Protein: Y1428_METMA
Sequence: MSKINGKIAVFTVFLVLVVVYGYMQAPTNREVKIDSFLIQFENGTTEPEVKAILENYNMTLNYSIDCNSDNGGYKYYIKVDKDDMPDVVKDGLKKDKNWTDSGSPSFTKGDYVIYPVTEQAIHDKNFLEILKRHNIQVKTFVWCLVSYRDNSTRYDVLGKNCITEKDANRITNELEMNENVLIVMPEYICY
What are the official names of this protein?
UPF0228 protein MM_1428.
What is the protein family that this protein belongs to?
Belongs to the UPF0228 family.
Protein: DDL_BUCAP
Sequence: MKKKIAVLLGGNSSERKISIKSGYAILQSLLRSGFNAYAIDTRDFPIMQLKKQGFDSAYIALHGTGGEDGSIQGILEYLNIPYTGSGIMSSAISLDKWRTKLLWKSLSLRVLPDIYLQKKDISKYTYSYILKKILKLKFPVVIKPNNAGSSIGITIVNHPDLLIDSINLAFNYSNNIIIEKFLKGTEYTVSILNKKVLPPIKIITKNNFYDYSSKYIESSTEYICPSGLNYQKEEELKKIVEIAWNSLGCKGCGRIDAILDNKDKFWLLEINTIPGMTHRSLVPMAAKSIGISFDELILKILKINK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODM_MYCSC
Sequence: LHHSKHHATYVKGVNDAVAKLQEARANDDHAAIFLNEKNLAFHLGGHVNHSIWWKNLSPDGGDKPTGELAAAIDDAFGSFDKFRAQFSAAANGLQGSGWAVLGYDTLGSRLLTFQLYDQQANVPLGIIPLLQVDMWEHAFYLQYKNVKADYVKAFWNVVNWAE
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: FADI_KLEP3
Sequence: MSQALPLITRQGDRIAIVRGLRTPFARQATVFHGVPAVDLGKMVVGEMLARSDIPADVIEQLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLFSRLRPRDLLPVPPAVAEYSTGLRMGDTAEQMAKSWGITREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQDNNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLTPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASERFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMIVEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_THETH
Sequence: MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAATMDFMEQERERGITITAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQVAYRETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGVIPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_NITOC
Sequence: MLNFNIFLVGPMGSGKTTIGRYLARITGKNFYDSDREIESRTGVSIPVIFEIEGESGFRQRECKIIAELVQLNNIVLATGGGAVLAAENRRELSQRGIVVYLYAPPKQLYRRTSHDNNRPLLRTGNPLERLKCLLKERDPLYREVADVIIKTGKQPVKAVANEVLRQLRQYKGGAPQRKSFVHVKSNKGA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMDE_VEIPA
Sequence: MSNATTTNGKAPSQDVVAVIVGALAAMGYSADQIAHIRPIVSYNWKMEGRLRGNR
What is the function of this protein?
Subunit of the sodium ion pump methylmalonyl-CoA decarboxylase, which converts the chemical energy of a decarboxylation reaction into an electrochemical gradient of Na(+) ions across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis (PubMed:7070502, PubMed:6852015, PubMed:3609308, PubMed:2920730, PubMed:1991479, PubMed:7601825).  The epsilon subunit seems not important for the catalysis of either decarboxylation or Na(+) transport, but it improves binding of the alpha subunit and plays an important role in stabilizing the methylmalonyl-CoA-decarboxylase enzyme complex (PubMed:7601825).  Can also convert malonyl-CoA into acetyl-CoA (PubMed:6852015, PubMed:2920730).
What are the official names of this protein?
Methylmalonyl-CoA decarboxylase subunit epsilon.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MDEP_STAAS
Sequence: MIVNYLKHKFYNLLTTMVVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
What is the function of this protein?
Involved in multidrug efflux.
What are the official names of this protein?
Multidrug resistance efflux pump SepA, Antiseptic resistance protein SepA, Staphylococcal efflux pump A.
What is the protein family that this protein belongs to?
Belongs to the multidrug resistance efflux pump SepA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STRT1_DROME
Sequence: MSNMDPSDVRSTAQLILANARQGNSAYNMQYDMSRAHSINLITEDFLAGYMQDGRMSVVRRFFCLFVTFDLVFVSLLWLICIVINGDNIFTAFHKQIVEYTIYKSLFDVVAVAICRFLVLIFFYAILYINHWSIIALSTSGSCLFLISKVFVFDWLDSKQQVFEVILIITSFILAWGEAWFLDCRVIPQERHAQHYFRTMTSNDRTPMEQPAILIEQERPPQSVTDFYSLMDTARHSDEEDELDDEYTQMGLDCLRKAYEIIESSDWKVEKVNQKGDTIHSTQRDKIGKIYKLTARIKYPAKALMEDLFYRIEDCPKWNPALLESKIVRKINSYTDITYQVSVGGGGGMVKSRDFVNLRSCRLFYNGQICDDDETAQLSSDDGNSSLNRSCEGSVSTISDGDSNTPLLPSSVSSCKATFPTSSKGAAMPFDTLGNSLGAKSLGPIVNFDEEPPPLDQDEFEDAKDKVDGEANNMTKPNVPSVGKTKDRVWVTSAVSVQYAAVPPSPKYTRGQNIVSGFAFREIVGKSDSCIVEWVLCLDLKGYIPRYVLDAALTSSMTDYISNLRKHVNELRQKGRGRAPRTH
What is the function of this protein?
May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis.
What are the official names of this protein?
Steroidogenic acute regulatory protein-like.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GALC_MOUSE
Sequence: MANSQPKASQQRQAKVMTAAAGSASRVAVPLLLCALLVPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSEILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYELDENYFRGYEWWLMKEAKKRNPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYYVVRWILGAKHYHDLDIDYIGIWNERPFDANYIKELRKMLDYQGLQRVRIIASDNLWEPISSSLLLDQELWKVVDVIGAHYPGTYTVWNAKMSGKKLWSSEDFSTINSNVGAGCWSRILNQNYINGNMTSTIAWNLVASYYEELPYGRSGLMTAQEPWSGHYVVASPIWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHQHSMCIRPYLPYYNVSHQLATFTLKGSLREIQELQVWYTKLGTPQQRLHFKQLDTLWLLDGSGSFTLELEEDEIFTLTTLTTGRKGSYPPPPSSKPFPTNYKDDFNVEYPLFSEAPNFADQTGVFEYYMNNEDREHRFTLRQVLNQRPITWAADASSTISVIGDHHWTNMTVQCDVYIETPRSGGVFIAGRVNKGGILIRSATGVFFWIFANGSYRVTADLGGWITYASGHADVTAKRWYTLTLGIKGYFAFGMLNGTILWKNVRVKYPGHGWAAIGTHTFEFAQFDNFRVEAAR
What is the function of this protein?
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8769874, PubMed:10861297).  Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity).
What are the official names of this protein?
Galactocerebrosidase, GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 59 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RIMP_COXB1
Sequence: MSQARTLHRLIAPAVEALGFELVGCELFRRGATTILQVFVDKPGGIGLDECAKVSRQISAVLDVEDPIRGRYTLEVSSPGLERPLYTANHYRRFIGNKAKIRLREPREGQRQFRGMIVAVDNEEQVTLQLDNKILKVPLGEIEKANLIADFEG
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_VIBCM
Sequence: MAAILRYQLELFLLAVSFFSRIPVPVSLPYSSERMNQAGRYFALVGLLLGAICALVYSLATQLFSTNISVFLTMVLSLLLTGAFHEDGLADMADGVGGGMTAERRLEIMKDSRIGTYGSSALIMVLLGKYLLLTELADLTSLVPVWLLAYTLSRAVAASLIRNTPYVSDTDSSKSKPLAQQLSGTDVAVLSLTALATLLYFSWQFIGVMIAASLIFRQIFRQWLIRRLGGFTGDCLGAAQQLMEILIYLILLAFLQHEVMI
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_LIMF3
Sequence: MNLVLMGLPGAGKGTQAQLIVKDFDIPHISTGDIFRAAIKNQTPMGVEAKKFIDKGELVPDEVTNGIVQERLAQDDTKDGFMLDGFPRNLAQADALNAMLVDSDRQLDAVINIHVRPEVLVERLSGRFICRNCGTTYHRLYNPTKVEGTCDVCGGHDFYQRDDDKPETVKNRLDVNIKLNTPLIDFYKKQGVLYTIDGEQDIDKVYQAVKEVLTNL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBPB_ECOLI
Sequence: MRNFDLSPLMRQWIGFDKLANALQNAGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLEIQLEGTRLSVKGTPEQPKEEKKWLHQGLMNQPFSLSFTLAENMEVSGATFVNGLLHIDLIRNEPEPIAAQRIAISERPALNS
What is the function of this protein?
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpB, 16 kDa heat shock protein B.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LNT_SYNY3
Sequence: MGLATAPLGWTYVAWFGQIPLWIWIFRANTTRLNFTQLKQFLISRSLTAIAWGGGFYGVALFWITGVHPLTWLGVPWLASLAIAAFCWLAITAWGVVLVFVWLLAMAVWEVTTARTKVNSTFKKYLFILWGTASWCGLETLWSHSILWWSPVAYTQSPSQLHFLQWGAIGGPALLSAFIVAVNGFLALGLIDFLDGKTVNKNKQNWHYFLIAILIWLFCQGGGWLLYQKPLADTPEEKINVGIIQGNIPNQIKFNSEGWQRAIAGYTEGYKKLTEQGAEIVLTPEGALPYLWETVVAKSGFYQAILQTQVPVWLGAYGTKGDGYTNSLLTVDGQGKLLGRYDKFKLVPLGEYIPLSNVFGQLIQRLSPLKEQLLPGDRPQVLPTPFGPAAVVICYESAFPDLLRSQLLQGGEFILSSANNAHYSDTMAAQHHALDVMRAIEGDRWLARATNTGLSAIINPRGKTLWLSAMNQYEIHAAPIYRRRGLILYSRWGDWVVFLLLVVSAIAWLYQIVFPLNQR
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLMU_AFIC5
Sequence: MTDRSSLTLVLAAGEGTRMRSSRPKVLHEVAGRSLLANVLLAAPAGKQDRLAVVVGPDHQAVADEARKLRPEAQMFVQSERKGTAHAVLAAREAIAGGADDLLVVFGDTPLVTAETFARLQAALTGDVAIVVLGFRAKDPAGYGRLLVQGNELIAIREQADASEAERKVDLCNAGMMAFAGKSALTILERIGNANSKGEYYLTDAIGIAREMGLRAAVIETDEDEVRGINTKAQLAEAETVMQARLRRQAMEAGVTLVAPETVFLSADTTFGRDVVIEPFVVIGPGVSIDDGAVIHSFSHVTQSSIGKKVSIGPYARIRPGTSLGEGVRIGNFVETKAAVLESGVKVNHLSYVGDAHVGTNANIGAGTIMCNYDGFDKHRTEVGAGAFVGSNSSLVAPVKIGAGSYIGSGSVITREVPEDALVVERNEQVTRPGWAKRYRERKAEMKKPKT
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_IDILO
Sequence: MATQTLNLDVVSAEDKLFSGVVQTVQVTGSEGELGIYPGHAPLLTKIKPGMVRYVSEAGDEELLYVAGGVLEVQPGHVIVLADVAVRGDELDLQEAEAAKKRAEEAIADSGSDVTYAEAIAELSRALAQIDIIRKLKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PHS_MYCLB
Sequence: MTVLTDEQVDAALLDLNDWKHTDGALCRSIKFPTFLAGIDAVCRVAEHAETKDHHPDIDIRYRTVTFILVTHYADGITKKDITMARDIDRLIGD
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RNH_JANMA
Sequence: MDKIDIYSDGACKGNPGRGGWGALLVMGEREKEIFGGELDTTNNRMELKAVIEALNLLTRPCEVVVHTDSQYVQKGISEWIHGWKARGWKTAAKAPVKNVDLWQALDAAQARHKIEWRWVRGHNGHAGNERADALANRGVEVAA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_IDILO
Sequence: MGKKRSVSSQRWLKEHFDDQFVQKAQKKGLRSRAVFKLEEIQKRDKLIKKGQTVVDLGAAPGGWSQYVADYFNGDGQIIACDILAMDPIAGVDFLQGDFREESVLEALLERIGGKNVDVVLSDMAPNMSGNGTVDQARSMYLVELALDMCHQVLKPGGSFAVKVFQGQGFESFLKDVRAAFNDVKTRKPESSRARSREVYLVATDYKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_CLOAB
Sequence: MLKGRSLIDPMDFTVDELEEIFKLADDIIACPKEYMHAAEGKILATLFYEPSTRTRFSFETAMLRLGGQVVGFSEPNSSSVSKGETIADTIRVVSCYADIAAMRHPKEGAPKVASMYSSIPVINAGDGGHQHPTQTLTDLLTMRRTKKRLSNLTIGMCGDLKFGRTVHSLIKAMSRYDNNKIVLISPDELKVPEYIKKEILDKNNIEYKEAKRIEDVIEELDVLYMTRVQKERFFNEEDYIRLKDSYILNENKLKTAKKDMIILHPLPRVNEISYEVDNDERAYYFKQAKNGMYVRMALMAKLMGVL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ADEC_SHEHH
Sequence: MSNLMDKHTQKIDPQSLQHMLSVLRLEQLGDLKLTNVSLLDLINGEVIPGPILIDKGHIIAVGQEVDLLAAVRVVDCHGQIAVPGFIDAHMHVESSTMTPFEFERTTLPLGTTSIVCDPHELVNVMGRQGIDWFLRCSETMHQNMFVQISSCVPAVAGLDINGSDFSLDEMAAYREHKHVLGLAEVMDYPAVINGEQAMQDKLTTFNNLNLDGHSPLLSGLSLSAYVACGIQNCHETTNVEEGKEKLAKGMAVIMREGSVAKNLDALAPLITDFSSPYCLLCTDDRNPHEIANEGHINFMVKRLIQQHDIPAYLAYRVASWSAAKHFGLRRLGLIAPGYRADINLVSTLDAVDIQRVLIAGEFVDELTLESELEAKLEASSPPLHNTVKHRPITEAELTIPLKEGEYRVIGVVKDELLTNHLVCHFDGQHFAEPGVNKLAVIERYGHQLPPALSLVKGFDIEQGAIATSVGHDSHNIVVIGADEKSMAHAVNHLLEIGGGFCVVQQGEVTADLMLPLGGIMSLERSEKIAEQISDLKTAVKAIGVSLSEPFVQMSFLSLPVIPSLKMTVKGLFDVDQFKFVSLRVDS
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: CD051_RAT
Sequence: MSHFLYLAPEIQLPFSPLTSTEFELIRRKARELWQNEARWSTSSVTTYSGSYREKQLDEASCHRLAQRFGQPHFEYKPAPLPGGSAYNALPGQAGSQEAADGKGRLPDITSPSQDSTLNIKHKVAHQSWSSGTSRPTCLAYRPRHLSPSSKPKRPGFELLMSYRNRGRKLLRQLQRQWDYENKLGSSDDSDTDRFSSVTSGSSRRKFK
What are the official names of this protein?
Uncharacterized protein C4orf51 homolog.
Protein: DXR_LAWIP
Sequence: MFTYITSLPSPEWEKSFPRTISILGSTGSIGTNALDVIKSHKELFHIVALGGGKNVQLLAKQAIQWKPDYLAVQDETSKEALIPLLPINYKPSIFVGQQGYVKLASLPEVTTVLSAQVGAAGLHGTVAAAKNGKVICLANKETLVLAGKLIKNLCLQSGAVILPVDSEHNAIFQALYTRNPKTVQNIILTASGGPFRNKKYEFLKNVTPEQAINHPNWKMGTKISVDSATMINKGLEIIEAHYLYGLPSEQIKIVVHPQSYVHSLVEFTDHSLMAHLGTADMRMPIAHCLAWPNYLNVGVEPFVLSKIGTLTFEEPDLDSFPCINLARDALVAGTSAQIILNAANEVAVDAFLKKQIGFMDIPILISKALEADSTPEPTTLESIEALDQQTRHTISQWIEVH
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: ESTB_ASPFU
Sequence: MGDRPTPVPLPNSEQFYLENDRGEPYLIQVSWPLHWEDKQTGRGPLPIIYIVDGNALFLTATEAAWRRAAASHFAGGGIIVAIGYPLKGKLYDARRRSFDLTPPTACAPVGYGGADVFLDFIENSVRPAVQARFPQVSLAREALYGHSYGGLLALHALFTRPQSFDCYIASSPSIWWNSLCILHEAKAFVETKKVSHDQSPSLMVSWGSWEQHPPRWADELLDHYEARKRTAAELRMADNALDLCAMLHGCSRLHALIKTEYEGEDHTSVMSCSVSRGLTMFFEDWPFHQSG
What is the function of this protein?
Displays specific TAFC esterase activity but does not hydrolyze fusarinine C, which has the same core structure as TAFC (PubMed:17586718).  Hydrolysis optimizes but is not essential for TAFC-mediated iron uptake (PubMed:17586718). Both extra- and intracellular siderophores have been shown to be crucial for the virulence (PubMed:17586718).  Subsequent to chelation of iron and uptake, FsC and TAFC are hydrolyzed and the iron is transferred to the metabolism or to the intracellular siderophore ferricrocin (FC) for transport and storage of iron (PubMed:17586718).  Hydrolyzes both TAFC and DF-TAFC with equal efficiencies, suggesting that its function might not be restricted to the release of iron from the siderophore but might also include the degradation of the iron-free chelator to protect cells (PubMed:17586718).
What are the official names of this protein?
Siderophore triacetylfusarinine C esterase.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2742_VIBCH
Sequence: MKLTHSFIKQQARLGLNFFRYLLARMNHDRVNVNAGYLAYITLLSMVPMLTVLLSILSSFALFANAGEVIQDFVITHFVPAAGEVVKTALIEFVANTGKMTAVGGAFLFVAAIMLISNIDKNLNYIWRVQQKRRAVFSFSMYWMILTLGPILVGASIAATSYITSLKILDNEALSGVYNLFLRWLPFVLSYCAFVGLYLLVPNKKVHWQHAMLGALIAAILFELSKKGFAAYITQFPSYQLIYGALAAIPILFVWVYLCWLIVLVGAEVTAALGEREHWSDSQDMLHFAPLPKNEKE
What are the official names of this protein?
UPF0761 membrane protein VC_2742.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROB_STRZP
Sequence: MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKVAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSAIIHPVSLEEMKDYLVK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.