PharMolix/UniProtQA huggingface dataset:
Protein: UPPP1_BACC1
Sequence: MEQFYYILKYLILGLFQGLTEPIPISSSGHLVLAQHLLGLKIEGFSFELLVNSASLLAVLLIYRNDLIRLTKNGLSYIFTRAEDAKSDFFFIIYLVIATIPAGVIGVLFKDYIDQYLKGVKMVGISLLITAVGLWIIRNLRGRKNDGDLSMKDAIIVGLAQACALIPGISRSGATIVAAMLLGMKQETALRFSFLLYIPVSLGGLLLSITDIAKDPNLDTLFVPYIVAFIATFIMTYISLKWFMNIMAKGNLKYFSFYCIIVGVLTLIFL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLO2_CITK8
Sequence: MNLNSIPAFQDNYIWVLSNNEGRCLIVDPGEAAPVLNAIKEKNWQPEAIFLTHHHHDHVGGVKELLQHFPHVVVYGPAETQDKGTTRVVKDGDSALVLGHEFSIFATPGHTLGHICYFSHPYLFCGDTLFSGGCGRLFEGTASQMYQSLKKISALPDDTLICCAHEYTLANMKFALSILPHDSFINEYYRKVNELRAKNQITLPVILKNERKNNIFLRTEDPDLINEINKETKLQQPEERFAWLRSKKDSF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: NRDR_YERPS
Sequence: MHCPFCAAVDTKVIDSRLVSDGSQVRRRRQCLDCNERFTTFEVAELVLPRVIKSDEVREPFNEEKLRRGMLKALEKRPVSSDDVETAISHIKSQLRATGEREVPTKMVGNLVMEALKRLDKVAYIRFASVYRSFEDVREFGEEIARLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PAR32_YEAST
Sequence: MATFNPQNEMENQARVQEYKVSTGRGGAGNIHKSMSKPSPVLLPLKSNSKTVANNNNNGSNQEKVPRFAIGRGGAGNIFHDPHLTRSAQQLDSNDNINYNDVINDIDDYISPITSDMVDEGGSNPVTNTRSRISATRSHQSLHATTSSPNNNAPIVVGRGGAGNIFFNKKKVASNGGNEEDEIRGGNIEDEDTINANEDNLFVVTSNGNALAAIKSTSKKPKNKLKGKSAPEKFAIGRGGAGNIISPKSSRNTINHNLNDDDEDKFNLKDDNGKEKKKKKKKKSGFFSSLKTMFN
What is the function of this protein?
Involved in resistance to cisplatin.
What are the official names of this protein?
Protein PAR32, Protein phosphorylated after rapamycin 32.
Protein: MNMC_VEREI
Sequence: MTQRGEVPDFLHGCGLPAAWAGLPQWRILETGFGFGLNFLATWAAWRADPHRPVLLHFVATEAQPVSAADLLRAGSARPGLAPLAQELSRQWWGLLPGLHRLRFDDGHVLLTLCLGDWQAQLRQQRQQLTVDSVYLHDLPQDWRPQRHPAPAGLPGLPGLKAVAACCRRGTRLASRCSTVRDALVQCGFTLHPAPGSDAQRDMLHAVYQPHWQPRTMRPAAAPATPGECMVIGGGIAGAATAASLARRGWQLRVLDQAAAPAAGASGLPAGIFAPHVSADDNLLSRLSRSGVRSTLEQARWRLREGLDWSHCGVLEHRADASPGLPARWSDGPGADGRQSAAHAALGALAQSGLPANASVCWHPQAGWIRPARLVAALLAQPGIRWQGACRVARLRRVQAPGAGPTAWQALDAQGRVLAQAPTVVIAAGAGSLELLEHRWPLQPVRGQVSWGLHGDPAAPLLPFPVNGHGHLVPRFPLGDDAQGPCAWVMGATFERGVEQMPPAPADVQAAHASHWARLQTLLPRMAPPLESAFAAARADAGLAASARAAQSWAAVRCTAPDRLPIVGPVDAAALPGLWVCSAMGARGLTLALLCGELLAARLQGEPLPIEHRLAKALDSGRM
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity).
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_METAC
Sequence: MSFLTNFLLGLGLAMDAFAVSMSSGTTIRPFRVSDALKLAVFFGSFQAMMPVLGWIGGSTVSSFVSDYAPWIAFLLLAFIGCKMIYEALYGDQDGKVNSLNYSVLFLLAVATSIDALAVGMSFAFLGTPILEPVIIIGCVTFVMSFCGAILGYRLGHFFEHEVEILGGLILIGLGGKILAEHMLWI
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PRMA_STAA1
Sequence: MNWTELSIIINHEAVELATNILENHGSNGVVIEDSDDLINQPEDKYGEIYALKKEDYPDKGVRLKAYFNEMTYDDKLRQQIKDELLNLDELDQHNIQFSEQIIAETDWENEWKNYFHPFRASKKFTIVPSWETYAKEADEELCIELDPGMAFGTGDHPTTSMCLKAIETYVLPQHSVIDVGTGSGILSIASHLIGVKRIKALDIDEMAVSVAKENFRRNHCETLIEAVPGNLLKDETEKFDIVIANILAHIIDEMIEDAYNTLNEGGYFITSGIIKEKYEGIQSHMERVGFKIISEQHDNGWVCLVGQKVSE
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM88B_BOVIN
Sequence: MSDQERETEEDEGGDPSDTAPMLPQRLPDHQASDLMSPGWASLAARGLGTLLFQGWALARLLLHLLLPAAVFLLVLLPAAAVVYLGFLCHSRVHPAPRPACRALLSDRGSAAVIVLGFLSLPPLLVLASAARARLARRLHSLLPPPTWSPGPHRQSDGEKQLCAWV
What are the official names of this protein?
Transmembrane protein 88B.
What is the protein family that this protein belongs to?
Belongs to the TMEM88 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TSGA_ECO8A
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFLLMVLAVAGLMFSHSLALFSAAMFILGVVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMIAAFLLARSIEWYWVYACIGLVYVAIFILTFGCEFPALGKHAPKTDAPVEKEKWGIGVLFLSVAALCYILGQLGFISWVPEYAKGLGMSLNDAGTLVSNFWMSYMVGMWAFSFILRFFDLQRILTVLAGLAAILMYVFNTGTPAHMAWSILALGFFSSAIYTTIITLGSQQTKVPSPKLVNFVLTCGTIGTMLTFVVTGPIVEHSGPQAALLTANGLYAVVFVMCFLLGFVSRHRQHNTLTSH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_CLOB8
Sequence: MKKKVLVGMSGGVDSSVAAYLLKQQGYDVIGATMQIWQHDEEFEEREGGCCSLSAVDDARRVCDKLDIPFYVLNFRDYFKEKVIDKFVQEYIDGKTPNPCIECNKHLKFDELLRRARGIGADYVATGHYAKIEKRDDRYLLIRSDDDRKDQTYALYNFTQDQLEHTLMPCGDYEKTKIREIAKEIGLAVHNKKDSEEICFISDNNHGKYISEAEPNRVKPGNFVDKSGNILGKHKGIVYYTIGQRKGLGLSLGRPVFVTNINAKTNEVVLGSEDDIFKTELIATDVNFIPFDKLEKEIEVTAKIRYSARPAEATLIPLPNGRVKVIFKEKQRAITKGQSVVFYDDEIVVGGGIIESII
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4P_SCHPO
Sequence: MTAKMLHLVRYKFPSLEPASLFLIPGSFLQERFRRDILHRAVIYEADNDRQGTASSKRRNEITCSGRKLYRQKGTGHARVGDASSPIRRGGAKSHGPKPRDFSTKLQTQVYNLAMRIALSTRFINNELTILENPINLSQPKTRILLEVLKQHKLGHEYGKALFVLNDNYFEDESLKNNNLLLASRQLGYHCSFIPVGEFQVRDALKFGKLFIDSEAMSLIVEKFAQRNTLSDMDQPASLTAYVDANSSSFTKSKPEPSLSL
What are the official names of this protein?
54S ribosomal protein yml6, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS11_PICTO
Sequence: MNKTGIAHIYASQNNTIILVTDPTGAETIAKSSGGMVVKNDRDEASPYAAMRAADMVSEKLREREITDLIIRVRAPGGSKSKIPGPGAQSAIRALSRAGFKILRIEEVTPIPHDGTKKKGGRRGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: SL_CROVE
Sequence: DLPSGWSSYEGH
What is the function of this protein?
Inhibits coagulant activity in human plasma, possibly by interfering with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example) (Ref. 1).  Does not show fibrinogen-clotting activity and does not inhibit ADP-induced platelet aggregation (Ref. 1).  Also does not show hemorrhagic activity in mice (Ref. 1).
What are the official names of this protein?
Snaclec uracolectin.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOH_PROMI
Sequence: MTQEMQSLALVPQGSIEAYIRAANSYPMLTAEEEKELAERLHYEGDLEAAKTLILSHLRFVIHVARSYSGYGLPQADLIQEGNIGLMKAVRHFNPEVGVRLVSFAVHWIKAEIHEYVLRNWRIVKVATTKSQRKLFFNLRKNKKRLGWFNQDEVELVAKELGVSESDVREMESRMSAQDMAFDMSADDSDDPHPVAPVLFLEDKSSDFADGIEEDNWDNHAADRLTLAIKTLDERSQDIIRARWLEDDNKSTLQELADKYGVSAERVRQLEKNAMKKLRLAIED
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is involved in regulation of expression of heat shock genes.
What are the official names of this protein?
RNA polymerase sigma factor RpoH, RNA polymerase sigma-32 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_CLOBA
Sequence: MSLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDISIYINSPGGSITAGMAIYDTMQYIKPDVSTICVGMAASMGAFLLSSGAKGKRYALPNAEIMIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQPLEVIEADVERDNFMTADEAKAYGLVDKVITKNGTGKDK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SHELP
Sequence: MAKIINVIGREIMDSRGNPTVEAEVHLDGGFVGMAAAPSGASTGSREALELRDGDKSRYMGKGVLTAVANINGQIRDALMGKDATAQAELDQIMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGMPLYAHIAELNGTPGQYSMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKSFREALRMGAEIFHNLKKVLQEKGLNTAVGDEGGFAPNLASNADALAVIKVAVEKAGYKLGEDVTLALDCAASEFYKDGQYDLSGEGKVFDSNGFSDFLKSLTEEYPIVSIEDGLDESDWDGWAYQTQILGDKIQLVGDDLFVTNTKILSRGIENKIANSILIKFNQIGSLTETLAAIRMAKDAGYTVVISHRSGETEDATIADLAVATAAGQIKTGSLCRSDRVAKYNQLLRIEEQLGEKAPYKGRSEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ATPA_ECO55
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPLDHDGFSAVEAIAPGVIERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSFEAALLAYVDRDHAPLMQEINQTGGYNDEIEGKLKGILDSFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SOMA_SHEEP
Sequence: MMAAGPRTSLLLAFTLLCLPWTQVVGAFPAMSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSPK_ALKCK
Sequence: MRNKAKGFPNPISFNGNKANNADEHASKRPDGTTRDRPQERMRSSNHFNSL
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: Y741_RHIME
Sequence: MLYYALVFLIVAIIAGVLGFGGIAGASAGIAQVLFFLFLIFLVISLVAGLIRRT
What are the official names of this protein?
UPF0391 membrane protein R00741.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOZ_NITWN
Sequence: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSQLTIDRDNDKNPVVALREIAEQTISPEDMREELVHSLQKFVEVDEPESDTVPLIGSAGASVDADDTEVAVERMTEEELLKGLEGLAPPEEQPEEDE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ASSY_ACTSZ
Sequence: MSNTILQNLPEGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYNAIPKKAMAYGAENARLIDCRTQLAQEGIAAIQCGAFHISTGGVTYFNTTPLGRAVTGTMLVAAMKEDDVNIWGDGSTFKGNDIERFYRYGLLTNPNLKIYKPWLDDQFIDELGGRFEMSQFLIANGFDYKMSVEKAYSTDSNMLGATHEAKDLEDLSTGINIVKPIMGVAFWDESVEIKPEVVTVRFEEGVPVELNGKRFDDVVELFMEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIAYERLLTGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQALMLRESSQRWVAKAITGEVKLELRRGNDYSILDTVSPNLTYEAERLSMEKVEDAPFDPIDRIGQLTMRNLDVTDTRNKLGVYSKAGLLTAGQDAVVPQLDKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSP_ADE02
Sequence: MQRAAMYEEGPPPSYESVVSAAPVAAALGSPFDAPLDPPFVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLVDNKSTDVASLNYQNDHSNFLTTVIQNNDYSPGEASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTNKFKARVMVSRSLTKDKQVELKYEWVEFTLPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKFDTRNFRLGFDPVTGLVMPGVYTNEAFHPDIILLPGCGVDFTHSRLSNLLGIRKRQPFQEGFRITYDDLEGGNIPALLDVDAYQASLKDDTEQGGDGAGGGNNSGSGAEENSNAAAAAMQPVEDMNDHAIRGDTFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKPVIKPLTEDSKKRSYNLISNDSTFTQYRSWYLAYNYGDPQTGIRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTSQISNFPVVGAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVSENVPALTDHGTLPLRNSIGGVQRVTITDARRRTCPYVYKALGIVSPRVLSSRTF
What is the function of this protein?
Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid.  Involved in virus secondary attachment to host cell after initial attachment by the fiber protein.  Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions.  Mediates initial virus attachment to CXADR-negative cells.  Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus.  As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
What are the official names of this protein?
Penton protein, CP-P, Penton base protein, Protein III.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae penton family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Located at each vertex of the virion. Present in 60 copies per virion.
Protein: KU_ACTMD
Sequence: MRATWRGSVTVGLVSFPVRLTPVRQERGVRLHQVHRVDGGRVRHRRVCELCGEELEAADLARGHDSGAGVVLVEDEELAGLRALPSRAVEVVQFSPAGQVDPVLLGRAYYLEPEEPGTGSYSVLREVLERGGLVGIARVPLRGREVVAVVRPRGGVLVLQVLVWAEEVREPDFVVPVAVSGERELGLAASLVGAMTEDFDPAAFPDAYSAGLTRVVADKLAGQRLERQERQRREAGEVRQADETDEAAETEVPEVDIPASRAPGETGGELLAALRRSLERLRGGRR
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: AMPA_METSV
Sequence: MELIKEIETSRNSSVLLKAIFEGDDAPTLLVKKQSQITEYLKENVAYVYLGKKSEFGYKDAYEFARDLAENCARSYQLDLTTFVTEKLCIKGVVDAFTKGINFSAFQYYNLKTFTKRVNENSLSFYLENISQDVLNVFKKALILVDAQNFARNLGVTPPNELNSEQLAEIIRKDFKKYHNLKVKVLERKQIELLGMDLLLSVNKGSVYEPRVVIIEYKGNPSSQEKTVLVGKGITFDSGGYSLKPPKFMLGMKYDMSGSAIVAAVMKAIAQLKPNKNVSAIMCITDNRINGDASLPDSVYTSMSGKTVEVNNTDAEGRLVLADRLYYGATKLNATRLIDTATLTGTMLTALGQTYSGIYATSCKIWHQFEDAAKIAHEKVWRMPLHEDFNKTNKESLVADLNNYSNNEKSDCNTAAMFLKEFTNNVPYIHCDVAGTADKKGMGLGILVSTFVEFGKSQQRNCESCECDEQKCETKNCNIEESTTKIVKAKKSTAKKATTKKTTTRKTASKTKSTKSKARK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_RIPO1
Sequence: MKVRASVKKMCEKCRVIRRRGRVMVICSNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RING2_PONAB
Sequence: MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLEPDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation.  H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.  May be involved in the initiation of both imprinted and random X inactivation.  Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.  E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4.  Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.  Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers.  Association with the chromosomal DNA is cell-cycle dependent.  In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.  Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase RING2, RING finger protein 1B, RING1b, RING finger protein 2, RING-type E3 ubiquitin transferase RING2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells.
Protein: CFA36_XENTR
Sequence: MASDTEWVLESVLGFVSGPVWTVPVLEFMEQKCSVFDDEEENKLSYTEIHNEYKELVETLLTQHLNEVGISEEQFQEACTAPLAHSATLKTILQPVLAVEDFKIFKAMMVQKNIELQLQAIRIIQERNGVLPDCLQHGRDIISDLEQQEMKLVSEALRLSKEEYEREQLRRSAKELNLTLGEHSENKQSSGSERTPNNTELPVKTQKEEKQPVNMLESPYKEVSIKLKEMSNTEAAEAWLEQARKEAGILSSVTNLSQAEKEQLQKRAEYLRRRREELLAKKQESKKMAQNSEEHEEKATCSKQEMTEEEKKSLQRRKRLAEKLKEEVILSCEKSGSAS
What are the official names of this protein?
Cilia- and flagella-associated protein 36, Coiled-coil domain-containing protein 104.
What is the protein family that this protein belongs to?
Belongs to the CFAP36 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium, flagellum.
Protein: TRPE_VIBPA
Sequence: MRLCTAGRLKQLQGGLVNKAIEIKKLGQLEVLKASVPYTQDPTRLFHTICENKTDSLLLESAEIDSKQNLKSLLIVDSAVRIVCYGHTVSFHALTENGKNLLTHVNQNVRGEVASQFDGETLTLEFIQPCDTIDEDSRLREASSFDALRLVQHSFDLSSQDKHAIFLGGLFAYDLVANFEPLGDAVATNQCPDYVFYVAETLLVVDHQTESCQLQATLFVDGSQKAALESRIEDIRAQCTSPKRLPDATQVANITAQPSVPDQDFCQIVRDLKEFVVKGDIFQVVPSRRFTLPCPSPLAAYKELKQSNPSPYMFYMQDELFTLFGASPESALKYETDTNQIEIYPIAGTRRRGKRPNGEIDFDLDSRIELELRSDKKENAEHMMLVDLARNDVARISQAGTRHVADLLKVDRYSHVMHLVSRVVGQLRDDLDALHAYQACMNMGTLTGAPKIRAMQLIRDVEGARRGSYGGAVGYLTGEGTLDTCIVIRSAYVENGIAQVQAGAGVVFDSDPQAEADETRGKAQAVISAIQAAHSQPANKE
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.