PharMolix/UniProtQA huggingface dataset:
Protein: MEC_MYCTO
Sequence: MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDRPERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKLATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY
What is the function of this protein?
Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO.
What are the official names of this protein?
CysO-cysteine peptidase, Metallocarboxypeptidase Mec.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family.
Protein: YAK1_ARATH
Sequence: MDDIDSSDGAAAARAGEIGSIGVSTPWKPIQLVFKRYLPQNGSASKVHVAVKKPVVVRLTRDLVETYKICDPQFKYRGELNPKRYLTTPSVGVNNDGFDNVNYDLILAVNDDFCSSDSRQRYIVKDLLGHGTFGQVAKCWVPETNSFVAVKVIKNQLAYYQQALVEVSILTTLNKKYDPEDKNHIVRIYDYFLHQSHLCICFELLDMNLYELIKINQFRGLSLSIVKLFSKQILLGLALLKDAGIIHCDLKPENILLCASVKPTEIKIIDFGSACMEDKTVYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFPGGSEFDILRRMIEILGKQPPDYVLKEAKNTNKFFKCVGSVHNLGNGGTYGGLKSAYMALTGEEFEAREKKKPEIGKEYFNHKNLEEIVKSYPYKINLPEDDVVKETQIRLALIDFLKGLMEFDPAKRWSPFQAAKHPFITGEPFTCPYNPPPETPRVHVTQNIKVDHHPGEGHWFAAGLSPHVSGRTRIPMHNSPHFQMMPYSHANSYGSIGSYGSYNDGTIQDNSYGSYGGTGNMFAYYSPVNHPGLYMQNQGGVSMLGTSPDARRRVMQYPHGNGPNGLGTSPSAGNFAPLPLGTSPSQFTPNTNNQFLAGSPGHHGPTSPVRNSCHGSPLGKMAAFSQINRRMSAGYSGGSQSQDSSLSQAQGHGMDNFYQNEGYSGQFSGSPSRRQLDSGVKNRKQTQGGTTLSTGYSTHNNANSSLRSNMYNPSSTAHHLENPDTALSVPDPGDWDPNYSDDLLLEEDSADESSLANAFSRGMQLGSTDASSYSRRFNSNASTSSSNPTTQRRYAPNQAFSQVETGSPPSNDPHARFGQHIPGSQYIPHVSQNSPSRLGQQPPQRYNHGRPNAGRTMDRNHMNAQLPPSNTNSGGQQRSPRSSSYTNGVPWGRRTNNHVPNVPSTSHGRVDYGSIA
What is the function of this protein?
Dual specificity protein kinase that phosphorylates ANN1, ANN2 and CP29B at serine and threonine residues, and ANN1, ANN2 and ANN4 at tyrosine residues.  May regulate the phosphorylation status of annexin proteins (PubMed:26452715).  Acts as positive regulator in abscisic acid (ABA)-mediated regulation of postgermination growth and drought response.  May regulate the expression of ABA-responsive genes such as RD22, RD29A, LTI65/RD29B and RAB18 (PubMed:27264339).
What are the official names of this protein?
Dual specificity protein kinase YAK1 homolog, AtYAK1, Dual specificity tyrosine-phosphorylation-regulated kinase YAK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: UGT55_CAEEL
Sequence: MQLLTLPTLIFIFLNYGTPCLSLRILVYSPRMIPSHVAFVANIANLLGQRGHNVVVVDNVLRSDISNKLDLKVIEKVVKVETSANVAKLLADQSIPINFWSMRNEPEEQKKVMKQLGIIFLEQCKYLVSKEETVFNELKHLEFDFGIHEVFDICGIGIFEKLGIRKSVILSSTGMRDIVNEALGISSQLQDASILSDYGNSIPFYGIRRNLKFHSAWRNFFEVQSKTLEPLFETTSSFENLLRFSNLMFLNTHELADAHRPWSRRVHEIGGISFKFPMPLKNEYINLFNKYNSIILVSFGTTTPSFLMPEKYKNTLINTFQRFPDFLFIWKYEKDDEFTQKNKKGNVVFKKFLPQVDLLESRKIKLFITHGGQNSLLETFHSNTRTLITPLFGDQHRNAQIALENGLSHVLLKDQLANEELVYAAIKQGTESNKKLDDNLLKLSSNLKNAKQTSENLFLDTVESTYTDNLSPLNFEFYPKLYSSDQILLYLDSIAMFTLTLLTMILIRKFLL
What are the official names of this protein?
Putative UDP-glucuronosyltransferase ugt-55, UDPGT 55.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y793_PYRAR
Sequence: MKVGIVSWGAYIPKYRIRTEEVARIWGDDPLRIVDVYLVDEKSVEGIDEDAVTIAVEAARRAIRRAGIDPKKIGAVYAGTESKPYAVKPISSILVDALGLSNNVFAVDMEFACKAGSEGLVAAIGLVKAGQVEYGMTVGTDTSQGEPGEHLEYSASSGGVALIVGRDGVAAELEAVYSYVSDTPDFWRREGSPYPMHGEGFTGEPAYFRHIIGAAKGLMEKYGYKPSDFAYVVFHQPNGRFPVRAASMLNIPMEKIKPGIVVTHIGNTYNASALMGFAKVLDVAKPGDKILLVPFGSGAGSNAFVFTVTDVVQERQKTGVPTVEDMLRDKIYVDYAQYLKMRKMIKLFD
What are the official names of this protein?
UPF0219 protein Pars_0793.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. UPF0219 family.
Protein: RECF_HAHCH
Sequence: MGLSRIAFTNLRNISSLKLDTSARLLLFHGNNGSGKSSLLEGVYLLGRGASFRTKELDYAVSHLSDEMVCFGEAVNEDAGKSFRIGVSRQKTGKLTRVRINGESARTLSELAAALPILIVTPDTFGFINGGPGERRRFVDWGVFHVEHQFKVVWQNWRKLLLQRNKLLKSGNISRSELSAWDNQYVAYSDEISRYRDAYFAELKEILIESLKESSEQTRDIGDKLTITLSNGWYQNDVNHMDQLASSVESDVKKGFTTLGPHRADIKVKVGGVHAKEVLSRGQQKTLITHLYLSQLEILRRRTNQRPIVLIDDVGAELDTGNQVTLLTRMLEKGAQVFVTVLDKQQSEYLFGHFNQEYDTQMFHVEQGAVTKVHN
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBXG_BACSU
Sequence: MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVLLAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVGMSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTIILMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIGITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKIGITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGTIAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKHPFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRTQANLTKSEQAAE
What is the function of this protein?
Probable threonine transporter (PubMed:32743959).  Is also active as a minor serine permease (PubMed:32743959).
What are the official names of this protein?
Probable threonine/serine transporter YbxG.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYB6_SOLTU
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFPMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RECR_XANOM
Sequence: MSSLLEQLIEAFRVLPGVGQKSAQRMAYHVLEREREGGRRLATTLANAVEKVGHCVQCRDFTESEICTICASSSRDRQQLCVVESPADRLAIEHATGYRGLYFVLQGRLSPLDGIGPRELGLDRLGERLAAGEVTEMIIATNATVEGEATAHYLAQLARQHAVRPSRLAQGMPLGGELEYVDRGTLSHAFGTRSEVL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RBS_NEOHI
Sequence: MRVTQGTFSFLPDLTDEQINKQLAYIVSKGFSANVEYTDDPHPRNSYWELWGLPLFDVKDASAVMYEISSCRKAKPNYYIKVNAFDNTRGIESCVLSFIVNRPINEPGFLLQRQDFEGRTMKYSLHSYATEKPEGARY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PPAX_BACCZ
Sequence: MKINTVLFDLDGTLINTNELIISSFLHTLHTYYPNQYKREDVLPFIGPSLHDTFSKIDESKVEELITSYRQFNHDHHDELVEEYETVYETVQELKKQGYKVGIVTTKARQTVEMGLKLSKLDEFFDVVVTIDDVEHVKPHPEPLQKALQLLDAKPEEALMVGDNHHDIVGGQNAGTKTAAVSWTLKGRAYLEAYKPDFMLDKMSDLLPILSDMNRS
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: ZN219_MOUSE
Sequence: MEGSRPRILVGHLEPSPPAFDGELDLQRYSNGPGVSGTPGPGSPGMGAVGWSETRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQSSPAAEGLARPQVPSSSAFRCPFCKGKFRTSAERERHLHILHRPWKCSLCSFGSSQEEELLHHSLTAHGASERPLAATSTPEPPPPPQQEPRSALEPEPEPEPRPEPDREANPAPTPAPPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGSAPARAPQPPDLSLLAYEPLGPALLLAPAPAPAERREPPSLLGYLSVRAGEVRPNGEGADPGGGRSYGGFRPLPSALPNRARRHRTEEPEEEEEVVEAEEESWARGRSLGSLTSLHPNPGEGSGQPAPAAGTQARSTATQEENGLLVGGTRSEAGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSSAGPGPPPEPPPPSQRGSLQPQSGAKPTQASATWVEGTASTRPPSSSTGPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGAGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRQPRADTSPTYVRAPSGETPPSPPLEEEGSPGLSRSGEAGLGGQER
What is the function of this protein?
Transcriptional regulator (PubMed:20940257).  Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:20940257).  Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity).  Regulates SNCA expression in primary cortical neurons (By similarity).  Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (PubMed:20940257).  Plays a role in chondrocyte differentiation (PubMed:20940257).
What are the official names of this protein?
Zinc finger protein 219.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRCAM_RAT
Sequence: MQLKTMPKKKPLSAGRAPLFLFLCQMISALDVPLDPKLLDDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGSGTLVINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKERLEPIILRSGQSLVLPCRPPIGLPPAIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISLKVISVDELNDTIAANLSDTEFYGAKSSKERPPTFLTPEGNESHKEELRGNVLSLECIAEGLPTPVIYWIKEDGTLPVNRTFYRNFKKTLQIIHVSEADSGNYQCIAKNALGAVHHTISVTVKAAPYWIVAPHNLVLSPGENGTLICRANGNPKPRISWLTNGVPVEIALDDPSRKIDGDTIMFSNVQESSSAVYQCNASNKYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPMPTIEWFKGTKGSALHEDIYVLHDNGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTRFIKQPGYAVVQRGSKVSFECKVKHDHTLIPTILWLKDNGELPNDERFSVDKDHLVVSDVKDEDGGTYTCAANTTLDSVSASAVLRVVAPTPTPAPIYDVPNPPFDLELTNQLDKSVQLTWTPGDDNNSPITKFIIEYEDAMHEAGLWRHQAEVSGTQTTAQLKLSPYVNYSFRVMAENSIGRSVPSEASEQYLTKAAEPDQNPTAVEGLGTEPDNLVITWKPLNGFQSNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSVVNSTLAEAHWDPVPPKSVRGHLQGYRIYYWKAQSSSKRNRRHIEKKILTFQGSKTHGMLPGLQPYSHYVLNVRVVNGKGEGPASADRGFHTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYILKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSVGSGSQITEEAITTVDEGKKAGILPPDVGAGKAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV
What is the function of this protein?
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system.  Plays a role in neurite outgrowth in response to contactin binding.  Plays a role in mediating cell-cell contacts between Schwann cells and axons (By similarity).  Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons (PubMed:16039564).  Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons.  During development, nodes of Ranvier are formed by the fusion of two heminodes.  Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters.  Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
What are the official names of this protein?
Neuronal cell adhesion molecule, Nr-CAM, Ankyrin-binding cell adhesion molecule NrCAM, Neuronal surface protein Bravo, rBravo, NgCAM-related cell adhesion molecule, Ng-CAM-related.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted. Note=Localized to axonal membranes at the node of Ranvier of myelinated axons (PubMed:8947556).
Protein: KAD_SYNE7
Sequence: MARLIFLGPPGAGKGTQAVVVAEQLQLAHISTGELLRAAVTAQTPLGIEAKGYMDRGELVPDSLVLGLVRDRLQQPDTANGWILDGFPRNRSQAEALNLLLTEINQQVDRAVNLDVPDPVIIERMLARGRADDTESVIRRRLEVYREQTAPLIDFFRDRQQLLAIDGNSEVAAVTDRLVSALQVAA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_THIDA
Sequence: MKHAVKHIHFIGIGGVGMSGIAEVLLNLGYAVSGSDLADNAVTQRLAKLGARIHRGHAPSNIAGADAVVTSTAVQESNPEVVAAREKKIPIVPRALMLAELMRLRQGIAIAGTHGKTTTTSLVASILGEAGMDPTYVIGGKLTAAGTNARLGQGDFLVAEADESDASFLYLTPVIAIVTNIDADHMDTYGHDFDRLKTAFVDFCQRLPFYGMAVLCIDDANVREILPRITKPITTYGFDPAAQVRAVDTRFEHGQMRFTVKREGMADLDVTLNQPGLHNVLNALAAIAVATEVGASDAAIVKALAEFHGVGRRFQRYGEHPTKDGGCYWLIDDYGHHPVEMAATLAAARGAFPGRRLVLVFQPHRYSRTRDCFEDFVKVLSETDALVLTEVYPAGEAPIVAADGRALARAVRVAGKVEPVFVENVADVAATVRDLVQADDVVLVMGAGSIGQVAPALGERDAP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PSEWO
Sequence: MTNLRKTHPLLKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNHGWFLRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLAEWIWGGFAVDKATLTRFFAFHFILPFIITALAIVHLLFLHETGSNNPSGINPNSDKIPFHPYYTIKDALGLMLLLLVLLILALFSPDLLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTANQRSMMFRPISQTLFWILTANLITLTWIGGQPVEQPFIIIGQLASMLYFLLILVLMPTAGLFENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PKN1_BOVIN
Sequence: MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRNLGPVELVLRGSSRRLALLHQQLQELHAHVVLPDPAVGVHDAPQSPGTGDSACSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLHRALQACQLESQAAPDEAQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSARLAGPFPATHYSTLSKPAPLTGTLEVRVVGCRDLPETIPWNPSPSVGGPGTPDSRTPFLSRPARGLYSRTGSLSGRSSLKAEAENTNEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATATGTFSPGASPGPEARSTGDISVEKLNLGTETDSSPQKSPLGPPSSPSSLSSPIQATTTTPELPSETQETPGPTLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTNAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWDALLARRLPPPFVPTLAGRTDVSNFDEEFTGEAPTLSPPRDARPLTATEQAAFRDFDFVAGSC
What is the function of this protein?
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation.  Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.  Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization.  Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly.  Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.  Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus.  Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP.  Able to phosphorylate RPS6 in vitro.
What are the official names of this protein?
Serine/threonine-protein kinase N1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, Serine-threonine protein kinase N.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Protein: SAHH_COREF
Sequence: MAKVTDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRREYAEEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCNIFSTQDEAAAAIVVGDGTPEDPQGVPVFAWKGETLDEYWWCINQIFSWEGELPNMILDDGGDATMAVIRGREYEKAGVVPQPEANDSDEYIAFLGMLREVLAEEPDKWTRLADSIKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVRVTEADPINALQALMDGYSVVTVDEAIADADIVITATGNKDIISYEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVIRTTIKPQVDEFTFPNGKSIIVLSEGRLLNLGNATGHPSFVMSTSFADQTIAQIELFQNEGQYENQVYRLPKILDEKVARIHVEALGGKLTELTKEQAEYIGVDVAGPFKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9532_DICDI
Sequence: MGELFLLRNIKVAGSMSEQERDEVLEDDDDDEDNKSSQQERDEFVEDDDNNSIQSSPSCAQPLLTQYHDDGSTPLLIPERLQFPTSQNLTPRLIPERLQYPTSQNLTSIKRKTTRLRFGFGEISRVKKTIN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0276139.
Protein: YKNU_BACSU
Sequence: METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITIDEIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRLSFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTLVTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQISTFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELVAFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGDVHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGMITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQAHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTEHSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKKIYDLQYRDVKMINEPHEVG
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YknU.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRTP_STAAM
Sequence: MTKHIIVIGGGLGGISAAIRMAQSGYSVSLYEQNTHIGGKVNRHESDGFGFDLGPSILTMPYIFEKLFEYSKKQMSDYVTIKRLPHQWRSFFPDGTTIDLYEGIKETGQHNAILSKQDIEELQNYLNYTRRIDRITEKGYFNYGLDTLSQIIKFHGPLNALINYDYVHTMQQAIDKRISNPYLRQMLGYFIKYVGSSSYDAPAVLSMLFHMQQEQGLWYVEGGIHHLANALEKLAREEGVTIHTGARVDNIKTYQRRVTGVRLDTGEFVKADYIISNMEVIPTYKYLIHLDTQRLNKLEREFEPASSGYVMHLGVACQYPQLAHHNFFFTENAYLNYQQVFHEKVLPDDPTIYLVNTNKTDHTQAPVGYENIKVLPHIPYIQDQPFTTEDYAKFRDKILDKLEKMGLTDLRKHIIYEDVWTPEDIEKNYRSNRGAIYGVVADKKKNKGFKFPKESQYFENLYFVGGSVNPGGGMPMVTLSGQQVADKINAREAKNRK
What is the function of this protein?
Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress.  Catalyzes the oxidation of the terminal methyl side group of 4,4'-diaponeurosporene to form 4,4'-diaponeurosporen-4-al.  The C40 carotenoid lycopene is a poor substrate.
What are the official names of this protein?
4,4'-diaponeurosporene oxygenase, 4,4'-diaponeurosporene oxidase, Carotenoid oxidase, Diapocarotenal synthase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtP subfamily.
Protein: RL22_SHEPW
Sequence: MEVLAKHRFARTSPQKCRLVADQIRGLPVAKALEILTFSPKKAAVLVKKVLDSAIANAEHNEGADIDELRVGAIMIDEGPTMKRIMPRAKGRADRIIKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: AZOR_BEII9
Sequence: MKQILLIDVSPRGKDSASRSVADTLAARLTSLYPSAKLIRRDLAAQPLPHLDEITLRALSTRDAAEAERLKETARQSDQLTDELLESDLLVIATPMWNFGIPSVLKAWIDLVVRPGRTFQYADGEVLGLAKDKKAILVLASGGVFTEGPWRPWDFIEPYLRQILNFIGIVDVQTVRIEGMNIPELVVDAVPKANKAVAELVL
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RS7_PROM4
Sequence: MSRRNAAEKRPVLPDPQFNNRLATMMVARLMKHGKKSTAQRILSDAFGLINERTGSDPIELFETAVKNATPLVEVRARRVGGATYQVPMEVRQERGTAMALRWLVNFSRSRNGRSMAHKLAGELMDAANEAGNAVRKREETHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.