PharMolix/UniProtQA huggingface dataset:
Protein: METK_BACC1
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKDDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELIDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF385_ASFB7
Sequence: MDEIINKYQAVEKLFKEIQQGLAAYDQYKTLISEMMHYNNHIKQEYFNFLMIISPYLIRAHSGETLRNKVNNEIKRLILVENINTKISKTLVSVNFLLQKKLSTDGVKTKNMWCTNNPMLQVKTAHNLFKQLCDTQSKTQWVQTLKYKECKYCHTDMVFNTTQFGLQCPNCGCIQELMGTIFDETHFYNHDGQKAKSGIFNPNRHYRFWIEHILGRNPEQELGTKQDPCGTKVLQQLKKIIKRDNKCIALLTVENIRKMLKEINRTDLNNCVSLILRKLTGVGPPQISESILLRGEYIFTEAIKIREKVCKKGRINRNYYPYYIYKIFDAILPPNDTTNRRILQYIHLQGNDTLANNDSEWESICMELPEIKWKPTDRTHCVHFF
What are the official names of this protein?
Zinc finger protein B385R, pB385R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B385R family.
Protein: Y386_HELPY
Sequence: MSLENDSLEITYLGKRYKISLNNTFSDEMKRTLKERFHNQELNALELLKDYLHESCQNEYLHNELQKLLEKISSCSIT
What are the official names of this protein?
Uncharacterized protein HP_0386.
Protein: PROA_STRP3
Sequence: MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALYSNKALVKLIRQSLEESGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMATKIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQHTSHHSEAIITRDTKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKIHARGPMGLEALTSTKFYINGDGHIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_PSEPF
Sequence: MTDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQSAVMVEALAQAGLHHDQVAAIGITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLKRDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERARNGELLFGTVDSWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGIAGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYALEGAVFNGGSTVQWLRDELKIVNDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGERLKALRVDGGAVANNFLMQFQADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKLYKGWKKAVSRTRDWAREDAE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PRLA_LYSSX
Sequence: VNVLGGIEYSINNATLCSVGFSVRVFNYAEGAVRGLTQGNACMGRGDSGGSWFTLFERQYGL
What is the function of this protein?
Has bacteriolytic activity.
What are the official names of this protein?
Alpha-lytic protease L1, Alpha-lytic endopeptidase L1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPNP_SALHS
Sequence: MLQSNEYFSGKVKSIGFTSSSTGRASVGVMAEGEYTFGTAEPEEMTVVSGALKVLLPGTVEWKVYAAGEVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FOXA1_RAT
Sequence: MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGAALSPGGMGSMGAQPAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNACFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSGGGGSKGVPENRKDPSGPVNPSAESPIHRGVHGKASQLEGAPAPGPAASPQTLDHSGATATGGGSELKSPASSSAPPISSGPGGWICTPLSPTWLAPHESQLHLKGAPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGATLPASLPLGGASVATRSPIEPSALEPAYYQGVYSRPVLNTS
What is the function of this protein?
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.  Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites.  Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'.  Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs.  Involved in glucose homeostasis; activates the GCG promoter.  Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles.  Modulates the transcriptional activity of nuclear hormone receptors.  Is required for maximal gene activation mediated by AR in the prostate.  Negatively regulates AR transactivation via competition with coactivators such as NCOA2.  Is involved in ESR1-mediated transcription.  Involved in regulation of apoptosis.  Involved in cell cycle regulation.  Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc.  Interacts with the cis-acting regulatory regions of these genes.
What are the official names of this protein?
Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, Forkhead box protein A1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDE3_SCHPO
Sequence: MSNESIYSVLDLTQVIFEDRYLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQKLLPQNCPEGHAKMIPCLLAWNPDVRPTAKYCKEVFFPLPPSASKSNSVPQKISNPKVEQNLGFPISREDKKSTRRVGWLKKNLSEFVSSVKSVFPDSHGSQPHVKTEKPINAKESTGHLANPIASSNVPAISLKPGELHESVFFSENEQIDYLLTSIDYLPSYKPPSNGSNIAINAFNETVGDRIPSSKDILITEKIPFKKENEIRDSIVPSCSQPDESNKEGVASCLLLQKSGMEMTSVLEYSTPNPAEVQNICNDHAKFETSKSLHLSSP
What is the function of this protein?
Protein kinase which is essential for spore formation.
What are the official names of this protein?
Sporulation protein kinase mde3, Mei4-dependent protein 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: ARGR_HAES1
Sequence: MINEKADSLVNAFKELLSQESFGSQSEIVSALQQMGFTHVNQSKVSRMLTKFGAVRTRNTRMEMVYCLPNELSVPNTGSPLKNLVLDVDHNETLIVIKTSPGAAQLIARLLDSVGKSEGILGTIAGDDTIFVTPTTGNDIQVLITNIQKLFESSL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_BACCR
Sequence: MIIGIGIDIIELNRIEKMLDGKLKFMERILTENERNVAMELKGSRLTEFVAGRFAAKEAYSKAVGTGIGKEVSFLDIEVKNDERGKPILITSTEYIVHLSISHSKEFAVAQVVLESLSR
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_OLEA2
Sequence: MAARTKNGLTASASGMQSLLPHTLPHADPAGPRDSLYPAFFTGIDEAGRGCLAGPVVAAAVILPPAGAPAAPHIAAALSGLTDSKKLSEKRRLTLEPAIKSCAVRWGVGVVWPQVIDRINILQATYRAMSLAVRHLRGGGAAASMPAGLPPVFLAVDGDKTIPGQVLQAVTGLSVPQEAIVGGDGCVMAISAASVLAKTFRDRLMTALDKRYSGYGFATHKGYGTAAHIEAIRRLGPCRMHRLSFAKVKPAAAPHAADQNTLW
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDRG1_MOUSE
Sequence: MLSPEAERVLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDLSVSEDVMVCFGNMFIKMPHPKTKEMIQKDQEHLDKEIERLRSQLKVKVNRLFEAQGKPELKGFNLNPLSPDEVKALKVILKG
What is the function of this protein?
May play a role in chaperone-mediated protein folding.
What are the official names of this protein?
p53 and DNA damage-regulated protein 1.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_SHESM
Sequence: MKLPIYLDYAATTPVDPRVAEKMFQYMTMDGIFGNPASRSHRYGWQAEEAVDVARNQVAELINADHREIVFTSGATESNNLAIKGVAHFYNKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLEPEANGIIPMERLEAAMRDDTILVSIMHVNNEIGVIHDVDAIGELCRSKGIIFHMDAAQSAGKLPIDVQTTKVDLISISGHKMYGPKGIGALYVRRKPRIRLEAQMHGGGHERGMRSGTLATHQIVGLGEAAAIAKAEMATDNARIAKLRDKLWNGIKHIEETYVNGDMTHRVSGSLNVSFNYVEGESLMMALKDLAVSSGSACTSASLEPSYVLRALGLNDEMAHSSIRFSIGRFTTEEEIDHAIETITQSIDKLREMSPLWEMFKDGIDLNQVQWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHCY_LIOMA
Sequence: DEPDGVPTRQKQ
What is the function of this protein?
Does not function as a hemocyanin.
What are the official names of this protein?
Pseudohemocyanin.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
Protein: RNC_AZOC5
Sequence: MSETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVSHMLYAAFPKAEEGELSRRLAELVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILADVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRDPKTVLQEWAQARGLPPPVYRDVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAP10_BOVIN
Sequence: MASAVSERLFSLELLVDWVCLEAGLPQPPVVAEEEQKEEGEGASPPRPSRSLCPAVAFRLLDFPTLLIYPPAGPAAPAQESRPGLVSFRRGKSCLFRLQPATLHRLLLRTPLYTLLLQLPPGHPTPAPQLLGACSISLAAAVHKVLGFAAPGSSQSHRGSFPLCNRDGERIGDIALGYRLSDLGSSLLGHLERPVASPGGGVEGMEVQKSVEVSPQTWQENQQLQQPDSEPSPGDADKPLVDVKISRAGKDLKGRAFHSKADSDYTDSMENGKTNSDMCSKGSSERSVSPPNQEGTEVELETNIICPPPLYYTHLTQEKTPPKQGKITIEPQINASEEWDDGTFLKENVNPPTHTNPPEHTNSATGESCSVLINPASVQDTGASNQTTDHPPTEQNRINTIRQLPLLNALLVELSLLYNQPMANPTHIHPHLAWLYRTEDKKSPESSVKSTCKSESKKDKLSVGENEKSVSLQYKKNQTENLKKGKYFEKKGGAPQKRVSRGKLLYGLTNTLKLRLKQTNPDMLVEYEKKEQYKKMQTQMLGAKLRIPSSKVKILSFAELYQKPHELPKDKCLESDASFAENSNTSKQISVVVDDPSTTTETKLNCATEKTVDCDENRSNNGFLGEILSPANSVVSERFICTNTLEGKVFGRKSIQSPGVFQQVAVVDRTVVDKEIDDKQVKITGDDILTVDINEKNPSTSSCSESISELKYSDDFTSPCSSEDTSRILRACDSSPGTENPKNSQHTSTSSETRLSIRKNSSAKSSILSPPFSAGSPVLSHKRFPVSKTQDKSLEEASSSDFSSSQWTEEKENQRDQNSMHNSKVIKQDHDISAKPKTRTGCKSSEKSQSPRTSQVSSYLPSNLSELELNVLDCSTLDHFEEDCDDLGSLNISKQCKDICELVINKLPGYTV
What is the function of this protein?
Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
What are the official names of this protein?
Microtubule-associated protein 10, Microtubule regulator of 120 KDa.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs (By similarity).
Protein: MSHA2_CATAD
Sequence: MESLPRRVALLSVHTSPLHQPGTGDAGGMNVYIVELSRRLADLGIEVEIFTRATTGALPPAVDLAPGVLVRHVTAGPYEGLSKEDLPGQLCAFTSGVLRTEAMHEPGYYDLIHSHYWLSGQVGWLAKERWGVPLIHSMHTLGKVKNAALALGDDPEPTARLVGEDQVVDAADRLIANTDQEASELVRLYGADPGRVSTVNPGVDLDRFRPGDKRAARESVGLPPDAAVLLFVGRIQPLKAPDVLLRAAAELIAREPERREKLVVAVVGGPSGSGLAEPTHLHRLARRLGIADVVRFVKPVDQTRLADWYRAADIAVVPSYSESFGLVAIEAQACGTPVVAARVGGLATAVADGRSGTLVAGHDPGDYATAVAGLLDAPHRLADFGENAVEHAARFGWSATAAATADVYSRSIEDLRALRYRELCAGQ
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase 2, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase 2, GlcNAc-Ins-P N-acetylglucosaminyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: UBIE_SALNS
Sequence: MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMVGETGKVILADINDSMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: PRSA_CALS4
Sequence: MRRKIALFLALIFVGVSLVSCSSKKEAVSGDVVAVVNGEKITNAEYQQIFEQVKEQIESAPTYTKDIWNQDYQGKKFLDFVKENVLDSLVAQKLLVQEAKKKNITVTDKEVEEEYNKEKQFNSKVTKEQIREYLLIDKLLAEYTKDVKVTDEELKKYYDEHKESFEVMRARHILVADEKTAEDIYQRLMKGEDFAALAKEYSIDTATKDNGGDLGEFPHGVMVPEFEEAAFSLKLGEISKPVKTQYGYHIIKSEGITVKPFDEVKGTIESYLLNDKKNKVIKEKYDELVKASKIQKFPENIKVKVG
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DNLJ_CYAP4
Sequence: MSNLEHEAERVEMAAATTEIRQRVLELRQLVQRASYAYYVLDAPILEDVVYDQLYRELQDLETQYPELLTPDSPTQRVGEQPATQFVSVQHRIPLYSLENAFAVADMQAWQDRWQRQGQAIGEQSATLRSPEYVCELKIDGSALALTYENGVLVRGATRGDGVYGEDITANVRTIRSIPLRLDWPDPPPIVEVRGEAFLPLDVFHRLNQEREQAGESLFANPRNAAAGTLRQLDARIVAKRRLDFFAYTLHLPLASARSATQPAAAQQLDLLAVAQSDPAVAAQQLDLSSASQAESVTTHLPQTQWQSLELLQQIGFRVNPHRQLCPTLADVRQYYDHWNHGRLDLPYMTDGVVVKLNSLRLQEHLGFTQKFPRWAIAWKYEPEQAVTEVLNISVNVGRTGALTPVAELRPVQLAGTTVSRATLHNRDRLAELDLHIGDKVVIHKAGEIIPEILQVFPELRPADARPYQLPTHCPECGQPVVQPVDEAVTRCLNVSCPAIVRGAIVHWVGRDAMDIDGVGEKLVRQLVDRGLVNSVADLYRLTVAQLLTLERMGNKLAEKVVAAIAKSQSRPWSRVLYGLGIRHVGSVNAQVLTTAFPSVERLMAASAEDIEAVHGIGPEIAQSIVQWFQTPANHSLIEQLSAAGVQLAQDTVAVPPSQLPQPLAGKTFVLTGTLPTLSRDEARSMIGQAGGKVTDSVSKKTDFLVVGADAGSKLDKAGQLGIPCLSESQLLELLEET
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL4_DEIGD
Sequence: MAQINVIGQNGGRSIDLDLPEVNPHVLHEVVTWQLAGRRRGTASTKTRAEVSRSGKKMYSQKGTGNARHGDRSVPTFVGGGVAFGPKPRSYSYTLPRKVRQLGLAMALADRQQQGKLTAVDGFGLDGKTKSFVSWAKENGLDGSERVLIVTDDELTRRAARNVAWATVLPVAGLNVYDILRHERLVIDAVALEPAQELETVPAEGNVQEGAAL
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TIM17_NEUCR
Sequence: MDHTRDPCPWVILNDFGGAFAMGAIGGTIWHGIKGFRNSPYGERRIGAITAIKMRAPALGGNFGVWGGLFSTFDCAIKGLRNHKEDPWNSILAGFFTGGALAVRGGYKAARNGAIGCAVLLAVIEGVGIGFQKMLAGATKLEAPAPPPSNEKVLA
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim17.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HIS1_RHOPB
Sequence: MTTPFVLAVPSKGRLQENAEAFFARAGLTLSKLGGARDYRGTIAGLDNVEIAYLSASEIAAQLARGTVHLGITGEDLIRESIADADKKVALIEGLGFGGANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRNFFAAHGVVDYRIVESAGATEGAPAVGTAEMIVDITSSGATLVANGLKVLDDGVILRSQANLVASRAADWSADALETARVILDRIAARARANKYKEVRTRFAGCDASLLTEAHNRFGVVSPFGGPTSSGMITLHCPPAQLYALGSFLRDHGADTVSIASLDYVLDRENPLFAKLESFLRQ
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3_BACCR
Sequence: MLMSLTNEQQERFQILLQQLQIPDDLINQYLQGGGIERLVIDKANKSWHFDLQVPRILPTELYELLETKLKQSFSHIARTTFALETENKQFTEEEVRAYWPLCTERITFSPMFAYLKKQLPQVNGVKLLINVNNELESTALKKNVAKPVGDQYEVFGFPRFQLDTHIQQNTEEMQKFREQTQQEDRERVIQAMEEMAKKQAEESSVVYEGPITLGYLIKPDEEITPMREIQDEERRKTVQGYVFHVETKELRSGRTLLTLKITDYTDSIMIKMFSRDKEDIPMLQSLKKGMWVKARGSVQNDTFVRDLVMIANDINEITGPSRKDKAPEGEKRVELHLHTPMSQMDAVTPVSKLVAQAGKWGHEAIAVTDHAVAQSFPEAYSAGKKAGVKVIYGVEANLVNDGVPIAYNEAHRLLAEETYVVFDVETTGLSAVYDTVIELAAVKVKGGEIIDRFESFANPHQPLSATIIELTGITDDMLTDAPEVDEVFKKFEEWMGDHTLVAHNASFDMGFINVGFKKAGLEKTNNPVIDTLELARFLFPEMKNHRLNTMCKKLDIELTQHHRAIYDTEATGYLLVKMLKDVIEKGFEYHDQLNDSMGQGDAYKRGRPSHMTLLATSDVGLKNLYKLVSYSHLNYFYRVPRVPRSLLKKYREGILVGTACDKGEVFEAMMQKAPEEVEEIAQFYDYIEVMPPEVLRHLVERELVRDEGQLKTIISNLVKLGETLDKPVVATGNVHYLDPEDAMYRKILVSSQGGANPLNRHSLPPVHFRTTDEMLECFSFLGEDKAKEVVVTNTQKIASLIGDVHPVKDDLYTPKIEGADDETRDMSYKMARSIYGEELPEIVEARLEKELKSIIGHGFAVIYLISHKLVKKSLVDGYLVGSRGSVGSSFVATMMEITEVNPLPPHYVCPKCKQSEFFNDGSVGSGFDLPDKECPACNIPYVKDGHDIPFETFLGFKGDKVPDIDLNFSGEYQPRAHNYTKVLFGEDYVYRAGTIGTVAEKTAYGYVKGYANDHNLTIRNAEIDRLVAGCTGVKRTTGQHPGGIIVVPDYMDIFDFSPIQYPADSIGAEWRTTHFDFHSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFSGPESLGVTEEQINCKTGTLGIPEFGTKFVRQMLEETKPTTFSELVQISGLSHGTDVWLGNANELIYNGTCTLSEVIGCRDDIMVYLIYQGLDPSLAFKIMESVRKGKGVPEEWEEDMKNNNVPGWYIDSCKKIKYMFPKAHAAAYVLMAVRIAYFKVHFALLFYAAYFTVRADDFDVEAMAKGSASIRARIDEIAQKGLDAAPKEKSLLTVLEMTLEMCERGYSFQKVDLYRSHATEFIIDGDTLIPPFNAVPGLGTNAALSIVEARKNGDFLSKEDLQQRSKVSKTIIEYLDSQGCLGDLPDQNQLSLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHA_MYCTU
Sequence: MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQILFTFLHLAASRACTDALLDSGTTSIAYETVQTADGALPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA
What is the function of this protein?
Catalyzes the reversible reductive amination of pyruvate to L-alanine.  However, since the physiological environment of M. tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine.  May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
What are the official names of this protein?
Alanine dehydrogenase, 40 kDa antigen, TB43.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
What are the subcellular locations of this protein?
Secreted.
Protein: NU4C_DIOEL
Sequence: MTSYFPWLTIIVVLPIFAASSIFFLPHKGNKVFRWYTTCICLTELLLTTYVFCYHFQLDDQLIQLEEDLKCINIFDFHWRLGIDGLSIGPILLTGFITTLATLAAWPVTRNSRLFYLLMLVMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKKRLYSATKFILYTAGGSVFLLIGVLGMGLYGSNEPTLDFERLANQSYPVALEIIFYFGFLIAYAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHSLFSPWLVIVGTIQIIYAASTSFGQRNLKKRIACSSVSHMGFIIIGIGSITDTGLNGAILQILSHGFIGAALFFLSGTSCDRIRFVYLDEMGGISLPMPKIFTMFSSFSMASLALPGMSGFVAELVVFLGIITSPKYLLMPKILITFVMAIGMILTPIYLLSMSRQMFYGYKLFNVPNSFFVDSGPRELFVSICIFLPVIGIGIYPDCVFSLSVDKIEGILSNYFHR
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.