PharMolix/UniProtQA huggingface dataset:
Protein: HPRK_STRPQ
Sequence: MPVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: UBA3_HUMAN
Sequence: MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
What is the function of this protein?
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme.  E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP.  E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.  Down-regulates steroid receptor activity.  Necessary for cell cycle progression.
What are the official names of this protein?
NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
Protein: THIC_RHORT
Sequence: MTAPFLSSLSPTSPLASATAPFPGSRKVYARPADAPHLRVPFREIILSDPGEAPVRVADPSGPYSDPEATIDLRQGLARHRASWASARGNSTVTAGRPAPSEGDFEAFPLTYAPLRRRDETPFTQLEYARAGVITDEMIYVATRENLGRDSAVAGACARLAGGEAFGAALPAHVTPEFVRAEIAAGRAIIPANINHPELEPTIIGRNFLVKVNANIGNSALGSSIEDEVAKLVWAIRWGADTVMDLSTGKAIHATREWILRNSPVPIGTVPLYQALEKVGGDATRLDWAVFEDTLIEQCEQGVDYFTIHAGVRLAHIPLTASRTTGIVSRGGSILAKWCLSHHRENFLYERFADICAILRRYDVAFSLGDGLRPGSVADANDAAQFAELDTLGALTAVAWEHGCQVMVEGPGHVPMHKIKANMDRQLATCGEAPFYTLGPLTTDIAPGHDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPDRADVKAGVIAYKLAAHAADIAKGHPAAQLRDDAISRARFDFRWSDQFNLGLDPEGARAFHDETLPHAAHKTAHFCSMCGPKFCSMKISHDIRDGALEGADALTQAGLDQMSATFRASGGEVHLDAQALDALAWEGKPAR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: YIDD_PASMU
Sequence: MAKTHSLSSKILIGLIRVYQVVISPLIGPRCRFTPTCSCYGIEAVKTHGAIKGSWLTLKRILKCHPLNAGGYDPVPPKINNKKEKK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4IN_SINFN
Sequence: MPSHCRERLPFALHFFAVAYGASLWILGSHGLAAANPACSARDDLSANMTISWTEIRAGCDAERTAYREQNPVGSSWFANAGNGFTGAPYLLQRVLPDLAPEIWGRNDENFGRFGFFPDPDDKSRPLPLGLGIASTAGRPLDAGGNPLGEIDFAKPGLDVVTLACGPHWTGTDAGWTGGRRGCAEHEDGRAQVAGCLLANGDSLLLHP
What are the official names of this protein?
Uncharacterized protein y4iN.
Protein: GATB_RHOCS
Sequence: MAYLIQGETGEWEIVIGLEVHAQVISNAKLFSGAATAFGAAPNSQVSFVDAAFPGMLPVINEVCVEQAVKTGLGLKAQINLRSVFDRKNYFYADLPAGYQISQFQQPVVGNGTIVLDLADGSTREVGIERLHLEIDAGKSLHDQHPSKTYVDLNRAGVALMEIVSKPDMRSPEEAAAYLRKLRTILRYLGTCDGNMEEGSMRCDVNVSVRKVGQPYGTRTETKNVNSIRYVQQAIEYEAQRQVELIEGGGTVVQETRLWDPNKGETRSMRSKEEAHDYRYFPDPDLLPLEIEQSWVDRIKETLPELPDDKKARFMADYGLSAYDAGILVAERARADFYETVAKGRDPKLAANYVIGDLLGALNKTGRDITESPIAADDLGGLIDLVTDGTISGRIAKDVFAEMLETGEKPSLIVEKKGLRQVTDTGAIDKAIDEVMAANADKVAEFRSGKEKLFGFFVGQVMRATQGKANPALVNEILATKLKG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DI194_ORYSJ
Sequence: MDSDHWISRLMAAKRQYALQRAQNHHHATATATATAASHSHLDRYGYDDVEPEDEVRPDFPCPYCYEDHDITSLCAHLEDEHPFESKVVACPVCSARISKDLLDHITLQHSYLFRLQRHHRLRRVAVPSNHALSLGGRDLQETYLKVLLGNSSRSSGTNAASSVTDSLLSSLVLNLSSSEAEDTAKFSALAVVENNWFKRTLPSKTWKASSDSNLSQEERERRRRRAAVRSSFVQHLLVSTLFDD
What are the official names of this protein?
Protein DEHYDRATION-INDUCED 19 homolog 4, OsDi19-4.
What is the protein family that this protein belongs to?
Belongs to the Di19 family.
Protein: MENG_MYCTA
Sequence: MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGDATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RS15_BORA1
Sequence: MSVADIKKAEIVSQFQRAQGDTGSPEVQVALLTARINELTGHFKEHAKDHHSRRGLLRMVSRRRKLLDYLKGRNPDSYRALIEKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL10_CHLTE
Sequence: MMKRDTKEQIAQEIAEKFQKSQGFYFTEFQGLDVQKMSQLRLEFRKAGIEYRVVKNTLIKKALKDAADVDKLAAGLKNTTAVAFAYDDPIAPAKIIKKFSKDNEALKFKMASIDGQVFGSDSLPQLSEMLSKTENIGRLAGLLNNMVASVPMVMNAVMRNLVSVIDQVGKLEK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y881_VIBCH
Sequence: MKIWVDADACPKVIRETLIRAAERTGVECTFVANHLIPLPKRDNIRALQVSSGFDIADNEIVRRTEAGDLVITADIPLADEVISKGGLALNPRGELYTKETIKARLNIRDFMDTMRASGIQTGGPAALSQTERREFANHLDRILAKRTG
What are the official names of this protein?
UPF0178 protein VC_0881.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: LFTR_NOSS1
Sequence: MQYDIASIIQGYAQGYFLMADDNDCLGWYGSRDRTLIPLDERFRYPKSLQRVLNQERFTVAINRDFAAVVAGCANRESTWISQELQEIYRLLYQTGYAYSFETWQGEELAGGILGIVIGGAFIGESMFYRIPEGSKVAMVKLVERLRQREFVMFDAQMMNPHLERFGAYRIKDKEYKTLLEKALLSPSTLI
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUD_ECOUT
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLLGETVDFNGKHIHVRGAKLLFPPIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEHVRAKAAAHGRKIRFGVRLHVIVRETNDEAWQAAERLISRLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVANDFIPRNVAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: ADDA_ALKMQ
Sequence: MKNWTTEQQAAIDARGSNLLISAAAGSGKTAVLVERIIQIILKDKIDIDRLLIVTFTNAAAGEMRERIAGAIMEEMERKTEQEAHLRRQINLLNRASITTIHSFCIDVVRRHFHIIDVDPGFRIGDITETSIMRLEALEELFEEEYQGAHETFFRLVEAFGGTKEDRPLQDLVLKVYGFIQSQPYPEVWLKEKVGDFSLSIEDFDESLWIKTIKSRIEIQLKGAMDLLNNALSIAQEPGGPEVYEEAILSDLGQISELYDSLTLPITSFYEHLNHINHARLKPSKESDPVLKEESKNLRDKAKGIIKDIKDNIFTVSPEAYVEDLNKLHPLMDYLYQLVTGFTSRYAQKKADRGIVDFNDLEHYGLEILANELVAQEYQQRFEYIFVDEYQDSNIVQETLIQSIKRKDNLFMVGDVKQSIYRFRLADPSLFIEKYETFGEKEGDINRRIDLAKNFRSRGEVLAGVNYLFKYIMSKELGEIGYDHRAALYQGASFESIKEPSIEVNLIEKNMEIDEDIEEELQELADIEVEARIIAKRIKDLLNEEIYDEKNEVYRRLEFKDIVVLLRTTKNWAQSFLEAFIREGIPAYADANTGYFEAIEVGMFLNLLKVIDNKRQDIPLISVMRSPIGEFTTAELIDIRINDKNGTYYDAIEKYIEKNEDALKDKLVSFIEKLNKWGNEARYIKIDQFIWKLLMDTGFYYYVGAMPGGLQRQANLRILFDRASQFEKTSIKGLFNFIKFIEKLQGSKGDMGAAKILGENDNVVRIMSIHKSKGLEFPVVIAAGMGKNFNLRDTSADVLLHKDLGLGPKFVDSNLRTYRDSIAKLAMKDQIKIESLSEEMRILYVAFTRPKDKLIIVGSLRKIDRLVTNWNQADNIYSLMNAKSYLDWIGAALIKHPHGEVLRELGDFEFNELKYKAEDSKWTVNILGRQAVVLEEHEKRLKEEEYKEKLTHFNREDFSPHRHTEHKEEIDNRLNWQYPYPQATVIPSKLSVSDIKKANMGEMDSIVHQIPTLVKTPKFMEGKKALTAAERGTIIHFVLQHLALNQVGSEEEISQQIDLMVARELITEEEAQVVNVGKIVNYFKSEIGKRMLGAEKVYRESPFIIEKSAKDVIHGLSENLEEKLLVQGVIDCYFEEMDGLVLVDYKNDIVLNGDTASIMTRYDVQLMMYAEALERITGKQVKETYLYLFDVDQGVKR
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: PPR3A_HUMAN
Sequence: MEPSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQPSRRGSDSSEDIYLDTPSSGTRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKEDLMQQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVPNSCDGETDQFSFKIVLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKEQEPEPVKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNFENPKNTDTYIPTIICSHEDKEDLEASNRNVKDVNREHDEHNEKELELMINQHLIRTRSTASRDERNTFSTDPVNFPNKAEGLEKKQIHGEICTDLFQRSLSPSSSAESSVKGDFYCNEKYSSGDDCTHQPSEETTSNMGEIKPSLGDTSSDELVQLHTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKKHEGGAKNIEVKDLGCLRRDFHSDTSACLKESTEEGSSKEDYYGNGKDDEEQRIYLGVNEKQRKNFQTILHDQERKMGNPKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPRTNLSWEEAVLTPEHHHLTSEGSALGGITGQVCSSRTGNVLRNDYLFQVEEKSGGINSEDQDNSPQHKQSWNVLESQGKSRENKTNITEHIKGQTDCEDVWGKRDNTRSLKATTEELFTCQETVCCELSSLADHGITEKAEAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRNDDSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKEETMSMYNPRKTHDREKCGTGNITSVEESSWVITEYQKATSKLDLQLGMLPTDKTVFSENRDLRQVQELSKKTDSDAIVHSAFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENAVTTMASQPISTKSENICNSTREIQGIEKHPYPESKPEEVSRSSGIVTSGSRKERCIGQIFQTEEYSVEKSLGPMILINKPLENMEEARHENEGLVSSGQSLYTSGEKESDSSASTSLPVEESQAQGNESLFSKYTNSKIPYFLLFLIFLITVYHYDLMIGLTFYVLSLSWLSWEEGRQKESVKKK
What is the function of this protein?
Seems to act as a glycogen-targeting subunit for PP1.  PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.  Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3A, Protein phosphatase 1 glycogen-associated regulatory subunit, Protein phosphatase type-1 glycogen targeting subunit, RG1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PNP_LEIXX
Sequence: MEGPEITFAEAMLDNGRFGARTVRFETGRIAQQAQGAVAAYLDEETMLLSATSASKHPKDNFDFFPLTVDVEERSYAAGKIPGSFFRREGRPSTEAILVCRLIDRPLRPSFVDGLRNEVQIVVTVLSIAPDEFYDALAINAASASTQISGLPFSGPIAGVRLALIPGNGAHEDQWVAFPKASQLEEAVFDLIVVGRVLTNEDGTEGDVAIMMVEAEATEGSWNLIQGGAVKPNEEVVAQGLEAAKPFIRQLVGAQAALAKQSAKAIADYPVFLPYSQETYDSVAALAYDELVNVYQIADKVERQNADDALKERVKAALAEKAQAGALDAEALTQFSAAYKSVSKVVMRGRVLREGVRIDGRGLTDIRPLDAEVQIIPRVHGSAVFQRGETQILGVTTLNMLKMEQQIDSLSPVTKKRYLHHYNFPPYSTGETGRVGSPKRREIGHGFLAERALVPVLPSREEFPYAIRQVSEALSSNGSTSMGSVCASTLSLLNAGVPLRAPVAGIAMGLISDVIDGETRYAALTDILGAEDALGDMDFKVAGTSEFVTAIQLDTKLDGIPSSVLASALKQAKDARTTILSVLDAAIDAPDEMAPTAPRVISVQIPVDKIGELIGPKGKTINAIQDETGADISIDEDGTVYIGAVDGPSAEAARAQVNVIANPTNPEVGEQFLGTVVKNAAFGAFVSLLPGKDGLLHISEVRKLAGGKRVESVDDVLSIGQKILVEITKIDDRGKLSLAPVLADEAETHGHDAASEGPTEG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_CARPA
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DUS29_HUMAN
Sequence: MTSGEVKTSLKNAYSSAKRLSPKMEEEGEEEDYCTPGAFELERLFWKGSPQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQRRRSQRQDGEEEDGREL
What is the function of this protein?
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (PubMed:17498703).  Involved in the modulation of intracellular signaling cascades.  In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity).  Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity).
What are the official names of this protein?
Dual specificity phosphatase 29, Dual specificity phosphatase 27, Dual specificity phosphatase DUPD1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VATE2_MOUSE
Sequence: MALTDIDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMDYFEKKEKQIEQQKKIQLSTMRNQARITVLRARDNLILELLKDAKMRLSRIVSDEEIYQDLLDKLVLQALLRLLEPVMIVRCRPQDLHLVESAVLRAIPQYMRLCQKHLEVQVDQTEHLPSNAAGGVEVYSSDQKIKVSNTLESRLNLAAMQKMPEIRGILFGDNTSRKFFT
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
What are the official names of this protein?
V-type proton ATPase subunit E 2, V-ATPase subunit E 2, Vacuolar proton pump subunit E 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: ARNF_KLEP3
Sequence: MGFLWALFSVGLVSAAQLLLRSAMVALPPLTDIVAFLQHLLHFQPGTVGLFFGLLGYLLSMVCWYFALHRLPLSKAYALLSLSYILVWAAAIWLPGWHEPFYWQSLLGVTIIVAGVLTIFWPVKRR
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADRC_PENRW
Sequence: MAPDEGDQAMSLQEEKPAYPSLSTTSSAELLHGAPLNDNERLDILQTAEHAMHRGSPKVDPHIWTNVTSHFSDSSTIDGRQRDILFERLTVRGKGSPFQIQQTILSALLYPLAYPIKRLVKLVGKKESHDGPGTILRGLNGIVCSGELLLVLGRPGSGCSTFLKSLCGYLEGLDVDTASEIQYKGVPFTTMMEKYRGDVVYNQEANHHFPNLTVGQTLEFAAHARAPHNRAGNQRGDQCQWRGKKESQVSLALFSLGGERTEGKAMRTDTVGMNSIAETVLSRASIVAWDNSTRGLDAATAVDFVRALRTSAKLSGSCHALAVYQASETLYNTFDQLILLYEGREIYFGSRERAVPYFESMGWKRPPQQVSADFLTAITNPGERQPQVGMEHAVPRTSLEFEAYWKSSPEHAELQRSMQQYKQKTPLDISEEIKLDEVKRLEQSTHARPSSPYLLSVPMQIRLCIVRAWQRTRNDIPGLVSSAVAQIVVSLIIGSLFYNIPQTTAGLGQRGSVLFLAVLTNALISLLEINTLYSQRLIVEKQAAYAFVRPFTEAIAGVIVDFPVKLFRCALSAIIIYFLANLRREASHFFIYILFQLTAVMTMATMFRTLATVTRTIGQAMSLAGVIIICVAVYTGFTVPQFDMPPWFAWIRWVNPIFYAFEAIVANEFHGRHFECVEYIPSLSFQEGLSFTCSYVGSVPGERYVSGDAYIAGSYDYSYDHVWRNYGILVAFLVFFYVLYFWLTELIPGTTPTHEVLIFRRGDAHPKLSRSDLESGEQPRPLQELKSLAPPAHPSMAEQKDTLSWNGVCYDIPVKGGEKRLLDDVSGWVKPGSLTALMGVSGAGKTTLMNVLARRMTIGVVTGDMLVNGHEPDASFSRKTGYVQQQDLHVETCTIREALRFSAALRQPQSVSTEEKYKFVEEVIQLLGMEDFAEAVIGNPGDGLNTEQRKLLSIGVELAANPQLLIFLDEPTSGLDSRSSWAICKFMRKLADNGQPVLATIHQPSAVLFEQFDRLLFLAKGGKTVYFGDVGHQARTVLEYLEKNGARQCGPTENPAEYMLEVIGGGTQGQSTPIDWVHAWKNSSENTQVLEELDSLVSSPSNAIPADPCKLSEFAMPLAVQFHHVMKRDLQQYYRQPEYILAKFGAGIFCGLFIGFSFWSSDNSSQGFQNVLFSLFLLCTIFSTLVNQIMPKFLSRRALYELRERPAKTYSWTVFILCQILVELPWQTLLGICTWASFYFSVYGDDQSPQRQVLILLFTVQFFLFASTFAQFVIAAVPNLVLGSMMATFTFLLCLLFNGIMQPPSALPRFWIFMNRVSPLTYYVGGISATALHGRPIHCSNRELRVFDPPQGQTCGQYLAEYLKTAQGTLHNPLSSDRCQYCPLRVADQYLAARDISWHDRWRNFGVFSVYIIFNIIGAIGLYYLVRVLPYAMKNRTQKSPT
What is the function of this protein?
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the meroterpenoid compound andrastin A, a promising antitumoral compound (Ref. 2).  Is required for the production of andrastin A but does not have a significant role in its secretion (By similarity).
What are the official names of this protein?
ABC-type transporter adrC, Andrastin A biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ADEC_SYNFM
Sequence: MKWDTGRMARIIEAAQGKRVVDLCIRRCRLVNVLSGSIDTVDLAIHEGFVAGWGSYRAAREIDADGMYVCPGFIDGHIHIESTLLAPAQFCAAAVPQGTAAVVADPHEIANVLGLSGIRYFLEASEGLPLDFFFNLPSCVPATPLETSGAALRAPDLDALLPHERLIGLAEMMNFPGVLSGFPDVIDKLLLFQARRIDGHAPQLGDLGLNAYVAAGITSDHECTTLEEAREKLAKGMTVMIREGGQSRDLAALLPAVDEHTWPRCCFVSDDVHPDGLLREGHMNVIVNRAMSLGMAPVRALSLAALTPARHFRLDRRGALAPGYHADFSMSPTLNPWQPERVFKAGVEVARDGRLLLDLGNGNGVAAPPSPMHITRLLAEDLVVPAQPGLLRIIGVREGTLLTRKIVLPPKIHEGAAVADLDRDILKLAVYNRYVPDRPPAVAFVQGLGLKEGAIATTVAHDSHNLIVAGASDADILHVVDAVRKSGGGMAAGRTGAEVDVLALPIAGLMSDQPVERVAERLEQLQGRARAAGSGLRNPFMALSFLALPVIPELKLTDLGLIDVSTFSPVSLFETS
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: BSLA_BACSU
Sequence: MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRTQSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNALRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFYAEASIDVAKRSTPPTQPCGCN
What is the function of this protein?
Involved in biofilm formation (PubMed:18978066, PubMed:21742882).  Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm (PubMed:22571672, PubMed:23904481).  The layer is stable and capable of resistance to high mechanical force compression (PubMed:28701036).  Required for complex colony architecture (PubMed:18978066).  May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix (PubMed:21742882).
What are the official names of this protein?
Biofilm-surface layer protein A, ORF-1.
What is the protein family that this protein belongs to?
Belongs to the BslA/BslB family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Note=Localizes to the biofilm matrix (PubMed:22571672, PubMed:23904481). Forms a distinct layer at biofilm surfaces (PubMed:23904481). Localization to the matrix is exopolysaccharide-dependent (PubMed:22571672).
Protein: HXD12_MOUSE
Sequence: MCERSLYRAGYVGSLLNLQSPDSFYFSNLRANGSQLAALPPISYPRSALPWATTPASCTPAQPATASAFGGFSQPYLTGSGPIGLQSPGAKDGPEDQVKFYTPDAPTASEERSRTRPPFAPESSLVHSALKGTKYDYAGVGRTAPGSATLLQGAPCASSFKEDTKGPLNLNMAVQVAGVASCLRSSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVQREQALALY
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D12, Homeobox protein Hox-4.7, Homeobox protein Hox-5.6.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.