PharMolix/UniProtQA huggingface dataset:
Protein: GME75_PESMI
Sequence: MNGQKDVVQVSEAWQTLSTYLPPVTADRDYWWQLTGRHVAALVEAAGYPIEKQYEALIFHYHWTVPYMGPAPKADGTPATWKSLLGLDGSPIEYSWKWNTTRSEPDVRYVTEPIGQHPGSHLDPLNQHALRELLQRFSKNMPSSDMNMSWVNHFFARLYDHDNTRYIQEAAAGSSRSTATSVQLGTEFLRRGIGFKTYFFPRKLGQVDDISISQYGASMSQLDVDETSWDARKALVEFLETNPEGKSLRPFSLAVDNVAPSQSRLKWYFHTLHTSIDSVREIMTLGGRINGIDKQLEELEDLIRVVAGLASDFPTNAEIPLPKKSDVYDQSAKDNFGELEDVLTGYLYYFDIAPGQGKLPEVKWFIPSRHYGPNDRELASALGAWMEARGRGAYNEPYMKMLHTLSAHRGLGDGKGLQTFISCLFKPSGDLDITTYLGAEAFHPGRVAKMAKPNGRSPRATLRRGDD
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
Prenyltransferase GME11375, Dibenzodioxocinones biosynthesis cluster protein GME11375.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: RS6_PECAS
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTATITGAQGTIHRLEDWGRRQLAYPINKLHKAHYVLLNVEAPQEAIDELETNFRFNDAVIRSMVMRVKHAVTEASPMVKAKDERRERREDFAEAGDDVEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MFNA_METPE
Sequence: MLNKGLAEEELFSFLSKKREEDLCHSHILSSMCTVPHPIAVKAHLMFMETNLGDPGLFPGTASLERLLIERLGDLFHHREAGGYATSGGTESNIQALRIAKAQKKVDKPNVVIPETSHFSFKKACDILGIQMKTVPADRSMRTDISEVSDAIDKNTIALVGIAGSTEYGMVDDIGALATIAEEEDLYLHVDAAFGGLVIPFLPNPPAFDFALPGVSSIAVDPHKMGMSTLPAGALLVREPQMLGLLNIDTPYLTVKQEYTLAGTRPGASVAGALAVLDYMGRDGMEAVVAGCMKNTSRLIRGMETLGFPRAVTPDVNVATFITNHPAPKNWVVSQTRRGHMRIICMPHVTADMIEQFLIDIGE
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis.  Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
What are the official names of this protein?
Probable L-tyrosine/L-aspartate decarboxylase, TDC/ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: ADHX_HUMAN
Sequence: MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI
What is the function of this protein?
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164).  Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420).  Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).  Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142).
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase 5, Alcohol dehydrogenase class chi chain, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3886_MYCA9
Sequence: MARRDGDSWEITESVGTTALGVASARDAETRSPNPLISDPYAGHFLAAAGDGAWNAYRFDGEPPAALVEAEPRLVERIDAMRSYVACRTKFFDDFFGDASTSGIRQAVILASGLDARAWRLDWPRDAVLFELDLPRVLAFKAETLDKQGATPRIRHVPVAVDLRDDWPAALRAGGFDVGRPAAWIAEGLLPYLPPAAQDLLFERIDTLSAPGSRIAVENFGEDFFNPETLARQRERGQAFRRVAEEMQGQDIPDVADLWYLEERTDAGEFLAGRGWRVTSETAVALLGRHGRDIPADLPDATPNSAFLFAQKAD
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAB_3886c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: HTYA_ASPRU
Sequence: MSTICAGGQTLESKYGGRAPPQIQLPDRQWPSKKLTESPIWLSTDLRDGNQALPNPMTTSQKWQMFRLLVDIGFKQIEVSFPCASDTEYTFTRALVETPGAVPDDVSLEVMTPCRKETLVRAVESLKGAKKAILFTYLATSDNYRETILQRSEAETLEHVRDCIEYARAITKEDPEARQTEWSLGFGMEDFANARPDAALRLAEVIQAAWQPSRENPVILGLASSVEAATVNIFADQVEYFSRHLSSRETVCISIHTHNDRGGAAAAAELACLAGGDRVEGCLFGNGERAGNLDLVTAAMNCFTQGMETGLDFSNLPEIRRVYESITQLPVHPRTPYSGDYYFRAFSGAHQDAIRKGLQKRAANSSKSPWKVPYLPLDPADLGVSFDNVIGVNSQSGKGGVAWLIQNGLALSIPTQLAASFSHVVKEQSVAQERGLAAEEICALFADRYDLRDSPSGRVVREHGYIAAFQHPGCALELEDVTEQAARAAGILTRGLDFLLRCTRAASHPLGGPDDSNLTVAFVQCAVTEKAEEAWGIGIGFSQDSAIDRALLSVMNRHYQPTPIRAPLATNDSVIPRPEPIRGG
What is the function of this protein?
Isopropyl malate synthase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630).  L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630).  This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630).  Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630).  The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630).
What are the official names of this protein?
Isopropyl malate synthase htyA, L-homotyrosine biosynthetic cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: CP4FB_HUMAN
Sequence: MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531).  Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081).  Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531).  Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081).  Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545).
What are the official names of this protein?
Cytochrome P450 4F11, CYPIVF11, 3-hydroxy fatty acids omega-hydroxylase CYP4F11, Docosahexaenoic acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, Phylloquinone omega-hydroxylase CYP4F11.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Protein: NUOM_ECO57
Sequence: MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLALSLQLWLQGGYSLTQSAGIPQWQSEFDMPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKEIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQASGLVMLIAILALVFVHYNATGVWTFNYEELLNTPMSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWSKMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQVVPVITVISTFGLVFASVYSLAMLHRAYFGKAKSQIASQELPGMSLRELFMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWFVNSVTTTRP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit M, NADH dehydrogenase I subunit M, NDH-1 subunit M, NUO13.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KCY_MYCGA
Sequence: MTKQINSQQIAIDGPAGSGKSTVAKLVAQRLGFDYLSTGKIFRAFYYLIKENNWSIDQLISNFNKYECAFNGDQVVINKENISQLLNDPTISKGASEIAQDPKIRAYALSLQQDYANKKPVVMDGRDITSVVLPNAILKVFLTASAQQRAIRRIKQLNLELNKATLEQFTNEIQQRDDNDTNRKLAPLMIVKDAIVIDSDQLSIEQVVDKIISLYKQRLGVNYA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLHD_ECO24
Sequence: MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEK8_MOUSE
Sequence: MEKYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSCCHGNTLLAVRSVTDEPVPP
What is the function of this protein?
Required for renal tubular integrity.  May regulate local cytoskeletal structure in kidney tubule epithelial cells.  May regulate ciliary biogenesis through targeting of proteins to the cilia.  Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
What are the official names of this protein?
Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
Protein: RRP1_MOUSE
Sequence: MVPGVPLPPEIQLAQRLAGNEQVTRDRALRKLRKYIEARSQRATGGFTPDELLKVWKGLFYCMWMQDKPLQQEELGRTIAQLVHAFHTTEAQHQFLKAFWQTMIREWVGIDRLRLDKFYMLMRMVLSESLKAVKARGWDERQIEQLLELLTTEILNPDSQAPSGVKSHFLEIFLEELAKVGAAELTADQNLQFIDPFCQIAARTKDSQVLHKIIQSIFQTIVEQAPLAIEDIMNELDTQSGEGEASDGDDGEASDGDDGEASDDDDGEASDGGDGDVADSDDSDGADDDDGDVSDGDGGDNDEGDSNKSSEGEQDLQDTPPKKLPAGTAHRAGPEADKEQAWDDEENAGPVLQFDYEALANRLFKLASRQSTPSQNRKRLYKVIQKLRELAGGTFPEDDVPEKAYKKMLEGRRERKKKKKRLPKPQPQNKEAGSEAESSSADPGPGRKRKRNRKTDEKAGQGGPPGKRRKPGARAKGAGAQQPKKRIQSSQSAE
What is the function of this protein?
Plays a critical role in the generation of 28S rRNA.
What are the official names of this protein?
Ribosomal RNA processing protein 1 homolog A, Novel nuclear protein 1, NNP-1, Nucleolar protein Nop52, RRP1-like protein.
What is the protein family that this protein belongs to?
Belongs to the RRP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RS2_PARD8
Sequence: MSRVNFDQLLEAGVHFGHLKRKWNPAMAPYIFMERNGIHIIDLYKTVAKVDEAAEVMKNLAKQGKKVLFVATKKQAKQVVADKAASVGMPYVIERWPGGMLTNFPTIRKAIKKMATIDKMTKDGTFDNLSKREKLQITRQRAKLEKTLGSIVDLTRLPSALFVVDVMKEHIAVREANRLGIPVFGMVDTNSNPNNIDYVIPANDDATKSVEVILGAICEAMNEGLQERKAEKIDAEAAEEAPKRERKAKAAVKKERTKKEDDDALNANVAGKFAKDEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: THIC_MYCBO
Sequence: MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: AROB_CAMJJ
Sequence: MQVEVKLKENAYKVYIDELEELEFDSKVFILSNPKISGLHLKTLLSKIKAKEIFIATVKDGEEYKNLSTMEEILNQMFNSKLDRKSVLISFGGGVISDMGGFAASIYQRGIDFINIPTTLLACVDAAVGGKTGVNNNFGKNLIGTFYQPKAVYCESSFLKTLSFRELAAGMAEFIKMAAMFDDSILDFIEKIDEKSFLNATCENEIFTQIIARSIELKSRVVEQDEKESGLRMLLNYGHTFAHVIENFTDYKLYLHGEAVAIGMVMANQLALNLGLLDKMQSQKIKDILLKFGLPISYKINNVDEFYEAFFMDKKSSNKKINFVLASPLGKGFIKGDISKEDIIATLREFQ
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATP_VIBCH
Sequence: MKYQQLENLECGWKWQYLINKWKDGEPVTRYIDKSEIEAAVQKLRAIEHEPTHVLSWIEEHMSSELDNKLKQAIRAKRKRHFNAEQIHTRKKSIDLDYRVWEKLSLKANELGCTLSDAIEYLLSEASRSEKASKTVNSLKEDLSRLLAE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAB23_CAEEL
Sequence: MPKEQYMCQLCANHGIFNQPKKGHKQKCPYRTCPCSLCALNTKRRALDQIERQLKHTNEPMTGQTATSMASPTPECPLSPTTPKMTPHTPTSGKDTFRNSISSSNMAFTVQLPATITKKELKLLRRDDTPLQNSLERPFPRSIDEAIETIKKEKMSSIFHSAEMLAVGESATSLI
What is the function of this protein?
Probable transcription factor that plays a role in the development of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays, by negatively regulating the activity of the transcription factor ast-1 (PubMed:22069471, PubMed:12231628).  Involved in male mating behavior, probably as a result of a role in the differentiation of male-specific diagonal muscles (PubMed:12231628, PubMed:22069471).  Required for development of the male proctodeum (PubMed:12231628).  May be dispensable in hermaphrodites (PubMed:12231628).
What are the official names of this protein?
DM domain-containing protein mab-23.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPT_OCEIH
Sequence: MSIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIVKTAVNANVKVLTLYTFSTENWKRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFNAVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHAVKQIVQKTKASELDVEQLDESYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALMEYQQRKRRYGGI
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RIR1_BHV1C
Sequence: MASDAFMQTACPADAAEQLEAEHAEWAQLGCGAVPPPPAAASRPSRAAVAAYVGEVVDRMRAQSRADERVYVKCGQLVHLRVRARSVPLDDWLTSAELALVSEVAEPVRANRAFVEVSLRYFELTEYATLRALGLQSALKYEEMYLAKLEGGAIESMGQFFVRIAATAATWTMREPAFGRALVGEGATWCAVFNAYLTALYRQLVVPATPIMLFAGRARGSLASCYLLNPQVSSSTEAVEAITTEVARILLNRGGIGISFQSFDRAVSRDCKRGIMGALKLLDSMAMAINSDSERPTGICVYLEPWHCDVRAVLNMRGLLARDESTRCDNLFSCLWVPDLLFDRYLAHLEGREGVVWTLFDDRASHLSRLHGPAFTAEYERLEREGLGVETVPVQDLAFLIVRSIVMTGSPFVMFKDACNRHYHMDTAGDALTGSNLCTEIVQRASPDAHGVCNLASVNLPRCVREGEGGALAFDFAALSTAAATAAIFVNAMMLGGQYPTEKAARGVARHRSLGIGFQGLHTLLLELGMDMLSPAARRLNVEIAERLLLAVMATSATLCEYGCAPFEDFARSKFARGLMPFDGYEGVVLSLPRAWARLREKVARHGLYNAQFVALMPTVSSSQVTEGSEGFSPVFTNMFSKVTMSGELLRPNLPLMRALRKHFTREASRLGAVRALDREQWSVAAALGDLAPGHPLAKFKTAFEYDQERLIDLCADRAPFVDQSQSMSLFVTEPMDGKVPASQIMNLLVYAYKKGLKTGLYYCKIRKATNNGVFTGGDLVCSGCHL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, R1, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: SUCC_SHEON
Sequence: MNLHEYQAKSLFAEYGLPVSEGFACDTAQEAVEAAGRIGGNLWVVKCQVHAGGRGKAGGVKVTGDKEEIRAFAEYWLGKNLVTYQTDEKGQPVAKILVESCTDIANELYLGAVVDRATRRVVFMASTEGGVEIEKVAEETPELIHKAIIDPLTGPQPFQARDLGFKLGLNPTQMKQFTKIFMGLATMFVDHDFALLEINPLVITTEGNLHCLDGKIGIDGNALFRQPKIKAMHDPSQDDAREAHAAMFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDSNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGTNAELGREVLAKSGLDIIAANSLTDAAELVVKAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: LPXD_XYLF2
Sequence: MPIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIVLHADDVKAASGAVLIAKDPYVTFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGAFVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTLISRVRLGKRVRIHPGAVLGGEGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHNCRIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGEYSSGTPLTDNRTWRKNAVRFKQLDMLVRRMMAVSKEKA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: PG035_VAR67
Sequence: MRTLLIRYILWRNDGDPSYYNDDFEKLMLLDELVDDSDVCTLIKNMRMTLSDGPLLDRLNQPVNNVEDVKRMIAISAKVARDIGERPEIRWEESFTILFRMIETYFDDLMIDLYGEK
What is the function of this protein?
Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
What are the official names of this protein?
Protein OPG035, Protein N1.
What is the protein family that this protein belongs to?
Belongs to the poxviridae OPG035 family.