PharMolix/UniProtQA huggingface dataset:
Protein: PROA_CERS4
Sequence: MDGTDVTMLMREIGVRARAAAAELAFAEPSRKEEALNAAAEAMLARSDEILEANGRDLAFGAEKGLTPAMMDRLKLDAARIDGIVEGLRAVAGQPDPVGQVIAEWDRPSGLHIRRVRTPLGVVGVIYESRPNVTADAGALCLKSGNAVILRGGSESFHSSGAIHAALQDGLRQAGLPVDAIQRVPTRDRAAVAEMLRMVEHIDVIVPRGGKGLVGLVQAEARVPVFAHLEGICHVYADGEADLEKARRVVLNAKTRRTGICGSAECLLIDRAFLAKHGPVLIEDLLKAGVEVRAEGELAQVPGTVPAQPEDFGREFLDMIIAAKVVDGVDEAIAHIRRYGSSHTESILTENDATAERFFRRLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHARGPVGAEQLTSFKYLVTGDGTIRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SASA_PROMP
Sequence: MNEKKELKLILVAARNHLSRGDLKLLLSYLESDDCEFEISLQISEPTEQPELLELHRLVAIPALIKVSPAPKQIFAGSNIFVQLQTWLPRWKQEGVTKDLGINLQPSKIDSIRTQKEFLLEEELLVLRQENETLTKRIESQERLLRMVAHELRTPLTAATLAIQSQKLGQIDIKKLQDVIKRRLEEIELLSQDLLEVGTTKWEALFNPQKIDLGNISAEAILELEKFWRLRKIEIDTDIPSDLPSVYADQRRMRQVFLNLIENALKFSENSGRIKITLIHKTNQWVEITICDKGAGIPVSEQKRIFLDRVRLPQTSEGTSGFGIGLSVCRRIVEVHGGRIWVVSEVGEGSCFHFTVPVWQGQNKDQQHLTKG
What is the function of this protein?
Member of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression.  One of several clock output pathways.  Participates in the Kai clock protein complex, the main circadian regulator in cyanobacteria, via its interaction with KaiC.  KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it.  In addition to its output function, recruits fold-shifted KaiB (KaiB(fs)) to KaiC to cooperatively form the KaiB(6):KaiC(6) complex (independent of SasA kinase activity).  Required for robustness of the circadian rhythm of gene expression and is involved in clock output, also required for adaptation to light/dark cycles.
What are the official names of this protein?
Adaptive-response sensory-kinase SasA, Sensor histidine kinase SasA.
Protein: LPOB_PECCP
Sequence: MKKYLGVILAALVLTGCPSRPPEPTEPPATIEPVEPQVPTTPTLPPGESVPQPPKIQTLNWEASINPLVAQMLQADGVTPGSILLVDSVKNNTNGSLPIAKATGALYSALSSGKAFTLVPREQLAAAKQTLGLSVDDSLGSRSKAIGLARYVSAQYVLYSDVSGDVKSPQIDMQLMLVQTGEIVWSGNGAVQH
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
What are the official names of this protein?
Penicillin-binding protein activator LpoB, PBP activator LpoB.
What is the protein family that this protein belongs to?
Belongs to the LpoB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: P3H1_STRSQ
Sequence: MRSHILGRIELDQERLGRDLEYLATVPTVEEEYDEFSNGFWKNIPLYNASGGSEDRLYRDLEGSPAQPTKHAEQVPYLNEIITTVYNGERLQMARTRNLKNAVVIPHRDFVELDRELDQYFRTHLMLEDSPLAFHSDDDTVIHMRAGEIWFLDAAAVHSAVNFAEFSRQSLCVDLAFDGAFDEKEAFADATVYAPNLSPDVRERKPFTKEREAGILALSGVIGRENFRDILFLLSKVHYTYDVHPGETFEWLVSVSKGAGDDKMVEKAERIRDFAIGARALGERFSLTTW
What is the function of this protein?
Dioxygenase that catalyzes the 2-oxoglutarate-dependent selective hydroxylation of free L-proline to cis-3-hydroxy-L-proline (cis-3-Hyp).  D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, and 3,4-dehydro-DL-proline are not substrates.
What are the official names of this protein?
L-proline cis-3-hydroxylase 1, P3H 1, Proline 3-hydroxylase 1, Proline 3-hydroxylase type I.
What is the protein family that this protein belongs to?
Belongs to the L-proline cis-4-/cis-3-hydroxylase family.
Protein: HIS7_DESVV
Sequence: MQTVARKASVERVTNETTIALTLTIEGEGNVRVTTGFGMLDHMLTLTAFWAGFDLDLTCNGDMHIDAHHTAEDVALCLGQALATALDDRKGIARVGFARVPMDEALAEVTLDISGRPWLEWRGDEYLPPVIAGEEKDLWREFHKAFASAARMNLHVSYLYGKNGHHLLESASKGLGLALRQAVRRDRQTVLSTKGSLD
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOE_LACLM
Sequence: MKITALEGQKISELSMIEVAHALLEQNGKEMQFSEIIRAIQDYLEKSDDEIKASISRFYTEINTDGSFIPLGNNVWALRSWYAIDEIDEEVIALDEIEDEEEEEKPAKKRKKVNAFGIEDEIDPEDEEGTKETTEEDMSYDTQAEDEDKDDVAAYDAELAEVELDNVDEEVDIEVEDDEDDSDDTDED
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: GYRA_TREPA
Sequence: MEEISTPEGGVLVPISIETEVKRAYIDYSMSVIVSRALPDVRDGLKPVHRRILYAMEEKGLRFSGPTRKCAKIVGDVLGSFHPHGDASVYDALVRLGQDFSLRYPVIHPQGNFGTIGGDPPAAYRYTEAKMARIAESMVEDIKKETVSFVPNFDDSDVEPTVLPGRFPFLLANGSSGIAVGMTTNMPPHNLREIAAAISAYIENPNLSIQELCDCINGPDFPTGGIIFGKNGIRQSYETGRGKIVVRARFTIETDSKGRDTIIFTEVPYQVNTTMLVMRIGELARAKVIEGIANVNDETSDRTGLRIVVELKKGTPAQVVLNHLFAKTPLQSSFNVINLALVEGRPRMLTLKDLVRYFVEHRVDVVTRRAHFELRKAQERIHLVRALIRALDAIDKIITLIRHSQNTELAKQRLREQFDFDNVQAQAIVDMQMKRLTGLEVESLRTELKDLTELISSLEELLTSPQKVLGVVKKETRDIADMFGDDRRTDIVSNEIEYLDVEDFIQKEEMVILISHLGYIKRVPVSAYRNQNRGGKGSSSANLAAHDFISQIFTASTHDYVMFVTSRGRAYWLKVYGIPESGRANRGSHIKSLLMVATDEEITAIVSLREFSNKSYVFMATARGVVKKVTTDNFVNAKTRGIIALKLSGGDTLVSAVLVQDEDEVMLITRQGKALRMSGREVREMGRNSSGVIGIKLTSEDLVAGVLRVSEQRKVLIMTENGYGKRVSFSEFSVHGRGTAGQKIYTQTDRKGAIIGALAVLDTDECMCITGQGKTIRVDVCAISVLGRGAQGVRVLDIEPSDLVVGLSCVMQG
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_FRATM
Sequence: MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPDLSKKQKLQSLVTDVEVLVGESGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILLANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDNHDKKCLPEIDKIILTASGGPFRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVLIHPQSVTHSMVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREACFERFEALKIVFNNLQNKNYAANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNFENPKNIEEVFEIDRKTREYVDSVLG
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NU1M_HYACU
Sequence: MKSLIVALAIVLAVAFMTLAERKLMGSIQRRLGPNHVGFLGLLQPFADGIKLILKETVLPLEANHWLFVLAPFLSFYLALLNWLVIPLAKGVVLMDMDLSILLILAISSLGVYAIIYTGWSANSKYTLLGSLRSTAQMVSYEIAMSLLVLTVVYMGATLNLTELAYLNSGTVLLWSLWPMAMIGFVAALAETNRAPFDLPEAESELVAGFMTEHSAISFTFLFLGEYANIITISTVLNLMFLGFYNPLVIYLFIWIRATLPRLRFDQLLRLGWQYLLPFLIGFLMIQPSTLFVLDLF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COX2_ALOPA
Sequence: MAHPAQLGLQNATSPIMEELIAFHDHALMIIFLISSLVLYVISLMLTTKLTHTSTMNAQEIEMIWTILPAIILIMIALPSLRILYMTDEFNKPYLTLKAIGHQWYWSYEYSDYEDLAFDSYITPTYFLEPGEFRLLEVDNRTTLPMEADIRMLISSQDVLHSWAVPSLGVKADAIPGRLNQVMLASMRPGLFYGQCSEICGSNHSFMPIVLEFIYFQDFEVWASYLYIVSL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYW_TREPA
Sequence: MLRVLTGDRPTGRLHLGHYAGSLGTRLRIQSEHECFFIIADLHTLTTRHGRAQLAELPALVRELVLDYLACGIDAQRAVIYLQSAVPEVTELAFIFANLVTVPRLQRIPSLKEMAQAANLSELPFGLLGYPVLQAADILLARAHLVPVGKDNESHVELTREVAKRFNRLYGEVFPLPRALLSDCATLVGTDGQAKMSKSLGNAIFLSDDEETVRRKVRAMYTDPARTRADIPGRVEGNPVFAYHDAFNPNTDEVAHFKERYRAGRVGDTEVKDALARALNTFLEPIRARRAQLEQQPAYLARVLEEGCARMRAEARKTMQRVKEAMGLSARPLVHLP
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPOP_MOUSE
Sequence: METLCPPPRLAVPASPRGSPCSPTPLKPRRGTPEFSPLCLRALAFCALAKPRPSSLGLGPGELAPRTPVLLGPPASPCTGGWAADGLKHLGGQAGRPSDVSSPAREDADVAVCPGGGEEEEGGGGFPHFGAGSCAPPGRCPAPLRPQDSPTNPAWSPPRPARGLDAASSPPLEPGSPPPSPPAGLSPEPAPSEQPVPASEAPGGGDPAPTAPEAPALSPSTADAAPDPPRDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGAAKKRRRPAPPPPSVQPRRPVPTLPTSSTFSLLDCFPCPPALVVEENGDLGPASSLRLQGDAKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL
What is the function of this protein?
Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226).  Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex (PubMed:27863225, PubMed:27863226).  Interaction with USP7 promotes deubiquitination of H2B at promoter sites (PubMed:27863226).  Acts as a regulator of neuronal differentiation (PubMed:23180766).
What are the official names of this protein?
Elongin BC and Polycomb repressive complex 2-associated protein, Embryonic stem cell-specific PRC2 subunit p48, ES cell-specific PRC2 subunit p48, esPRC2p48.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs) (PubMed:27863226).
Protein: SSG1_SORBI
Sequence: MSTLATSQLVATHAGLGVPDASMFRRGGVQGLRAAARASAAAGDALSMRTSACPAPRQQPAARRGGRGGRFPSLVVCATAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVVSPRYDQYKDAWDTSVVSEIKMGDGYETVRFFHCYKRGVDRVFIDHPLFLERVWGKTEEKIYGPDAGTDYKDNQLRFSLLCQAALEAPRILSLNNNPYFSGPYGEDVVFVCNDWHTGPLSCYLKSNYQSNGIYKDAKTAFCIHNISYQGRFAFSDFPELNLPERFKSSFDFIDGYEKPVEGRKINWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYIAVKYDVSTAVEAKALNKEALQAEVGLPVDRKIPLVAFIGRLEEQKGPDVMAAAIPLLMEEDIQIVLLGTGKKKFERMLMSAEEKYPDKVRAVVKFNAALAHHIMAGADLLAVTSRFEPCGLIQLQGMRYGTPCACASTGGLVDTIIEGKTGFHMGRLSVDCNVVEPADVKKVATTLKRAIKVVGTPAYEEMVKNCMIQDLSWKGPAKNWENVLLSLGVAGGEPGIEGEEIAPLAKENVAAP
What are the official names of this protein?
Granule-bound starch synthase 1, chloroplastic/amyloplastic, Granule-bound starch synthase I, GBSS-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Amyloplast or chloroplast, granule-bound.
Protein: 11014_ASFK5
Sequence: MKVLLGLLLGYSVLIHAYELPDLPRTQHPPKSELSYWCTYVPQCDFCWDCQDGICKNKITGSRFINSNHSIVNCRVFRDSKTQSCLYEISSKMPNHFNMECSHPRPYTGNEIFMKPWGGG
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 110-14L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
Protein: METE_BURA4
Sequence: MVTTHNLGFPRIGAQRELKFGLERYWKGESSRDELKALGAELRERHWNDQRDLDLAPIGDFSFYDQVLDMSFTLGNLPKRVQGFHGDVLDNYFRVARGRSAQAADEHATCCGGVSAGEMTKWFDTNYHYIVPEFHADTNFSLDPSCLLQQLAEARALGVAGKPVILGPVTYLWLGKAKDDSDRLALLPKLLPVYGALLDTLTAQGVEWVQIDEPILVTELDAEWRQALRTAYAALETRRIKVLLATYFGALGDNLTLAASLPVDGLHVDAINARDEVDALVRELPADRVLSVGAINGRNIWKTDLNATLDWLEPLAKQLGERLWIAPSCSLLHVPVDLASEQKLDPEIRSWLAFALQKLDELNVLATALNEGRDKVADALAANAAAIDSRRRSPRVNNPAVKAALARIDAQLGNRASPYTQRAPKQSARLNLPAFPTTTIGSFPQTADIRQARRQFKSGALDEAGYRAAMQAEIERSVREQESLELDVLVHGEAERNDMVEYFGEQLDGYAFSQFGWVQSYGSRCVKPPILFGDISRPKAMTVEWITYAQSLTNKPMKGMLTGPVTILNWSFVRDDQPRSVSCYQLALAIRDEVLDLEKAGVRVIQIDEAALREGLPLRRAQWGEYLKWAVEAFRITANGVQDDTQIHTHMCYSEFNDIIASIADMDADVITIETSRSDMELLDAFDSFRYPNEIGPGVYDIHSPNIPTQDHIVGLMKKAAERIPAERLWVNPDCGLKTRQWAEVIPALTNMVAAAKTLRNQVQ
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: AROG_AMYME
Sequence: MIDRLVRDSRGPVTERNPPHMSLSAGPAEISEGLDNQRTLGVSPLISPALLRQELPVDAAIAKTVAHGRSSAVDILHGDDDRLIVVVGPCSVHDPAAALDYAHRLAEHAAGVRDELHVIMRVYFEKPRTTLGWKGLINDPDLDGSYAVNKGLRMARKLLLDISALGLPVGCEFLDPITPQFIADTVSWGSIGARTAASQVHRQ
What is the function of this protein?
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: RL11_SULNB
Sequence: MAKKIAEKFKMMIPAGSANPSPPVGPALGQRGVNIMEFCKAFNEKTKDKMGFKIPVIVTVYVDKSFTFETKQPPASDLILKAAGIKKGTDNPILNKVGSITKAKLDEVIDQKIADLNTNDREAAAKILAGTCRSMGIEIVD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PHS_SCHPO
Sequence: MNTSARLLALVSKSKNNWILQQGDTKLFKSFRFKNFIEAWGFMSCVALRAQQLNHHPEWTNVYNKVDITLTTHDTKGLTEKDLKLAEFIDTLAKDN
What is the function of this protein?
Has a role in spore wall formation.
What are the official names of this protein?
Pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Overlapping meiotic transcript 2, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
What are the subcellular locations of this protein?
Spore wall. Note=Inner spore wall.
Protein: NDBT_LYCMC
Sequence: MTFITLTIGLSLRTIFLIFIFLPPPHLLARTTSLTRRQTRKTTIKVFVFILPFYQTPNW
What are the official names of this protein?
Venom protein 27.7.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: P20L1_BOVIN
Sequence: MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKAQHPLSWCCPSDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGNKPRTSANSNKDKEKDERKWFKVPSKKEETSTSITTPEVEKKEDLPTSSETFVGLHVENVPKMVFPQPESTLTNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDYNETAPMLEQVLHSL
What is the function of this protein?
Is a negative regulator of proteosomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (By similarity).  Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity).
What are the official names of this protein?
PHD finger protein 20-like protein 1.
Protein: SEC11_YEAS2
Sequence: MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Secretory protein 11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: ATL_STAAN
Sequence: MAKKFNYKLPSMVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTEQAKAEVKNPTQNISGTQVYQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATTNNTQPVAKSTSTTAPKTNTNVTNAGYSLVDDEDDNSEHQINPELIKSAAKPAALETQYKAAAPKAKTEATPKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEEDYTSYFPKYAYRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIETAPTDYLSWGVGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEYDGNGTVWTHYAVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQFTTTPTTPSKPTTPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAVSKTATLGNQKFYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKSGTKLYTVPWGTSKQVAGSVSGSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPIPKPSTPTTNNKLTVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKFYLVKDYNSPTLIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSGTGNQTFKATKQQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTKPQTTQTVSKIAQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTSHNIPLGWFNVKDLNVQNLGKEVKTTQKYTVNKSNNGLSMVPWGTKNQVILTGNNIAQGTFNATKQVSVGKDVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYYVTPNSDTAKYSLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQTGMTLNQVAQIQAGLQYKPQVQRVPGKWTDANFNDVKHAMDTKRLAQDPALKYQFLRLDQPQNISIDKINQFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGADVVNNKVVTNSNTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVKAGQNTLYKMRWNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK
What is the function of this protein?
Endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure.  One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.  Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells.  Acts as an autolysin in penicillin-induced lysis (By similarity).
What are the official names of this protein?
Bifunctional autolysin.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted, and then anchored on the cell surface at the peripheral cell wall above the completed septum (septal region), for the next cell division cycle.
Protein: DCR2_YEAST
Sequence: MIRLPRLYQRYLLYLVVFVVIALFYFLQAPRVEEHIGFDLALPISHVDNLWFQNKGLEGFSNDDKLVVNIGYDECFHIGRFYEGCFNRHELKSTLTDGHQYLQRKRIHKDLRGSFGRRWFGKSEYLYYDVLYPALVDYFGSNLEKLNVEAVTGISKYPKDKSLPFMDVSITFEPISIELLQKRSYISDINILFGVDCIQPIANWTLQKEFPLVKYRYSEPAYLTYKFVGTRPVDTGAQRLQETDEGKFKIVQLADLHLGVGESECIDEYPKHEACKADPKTETFVQQVLDIEKPQLVVFTGDQIMGDRSIQDSETVLLKAVAPVIARKIPWAMVWGNHDDEGSLTRWQLSEIASVLPYSLFKFSPHDTHDNTFGVGNYIYQIFSNNDTEVPVGTLYFLDSHKYSTVGKIYPGYDWIKESQWKYIEDYHDVNLKFKTGLSMAFFHIPLPEYLNIESKTHPGEKNPLIGMYKEGVTAPKYNSEGITTLDRLSVDVVSCGHDHCNDYCLRDDSTPNKIWLCYGGGGGEGGYAGYGGTERRIRIYEINVNENNIHTWKRLNGSPKEIFDFQSMLDGNSPESV
What is the function of this protein?
Required for cell cycle progression.  Has a role in the completion of START.
What are the official names of this protein?
Phosphatase DCR2, Dosage-dependent cell cycle regulator 2.
Protein: TBPB_NEIMB
Sequence: MNNPLVNQAAMVLPVFLLSACLGGGGSFDLDSVDTEAPRPAPKYQDVFSEKPQAQKDQGGYGFAMRLKRRNWYPQAKEDEVKLDESDWEATGLPDEPKELPKRQKSVIEKVETDSDNNIYSSPYLKPSNHQNGNTGNGINQPKNQAKDYENFKYVYSGWFYKHAKREFNLKVEPKSAKNGDDGYIFYHGKEPSRQLPASGKITYKGVWHFATDTKKGQKFREIIQPSKSQGDRYSGFSGDDGEEYSNKNKSTLTDGQEGYGFTSNLEVDFHNKKLTGKLIRNNANTDNNQATTTQYYSLEAQVTGNRFNGKATATDKPQQNSETKEHPFVSDSSSLSGGFFGPQGEELGFRFLSDDQKVAVVGSAKTKDKPANGNTAAASGGTDAAASNGAAGTSSENGKLTTVLDAVELKLGDKEVQKLDNFSNAAQLVVDGIMIPLLPEASESGNNQANQGTNGGTAFTRKFDHTPESDKKDAQAGTQTNGAQTASNTAGDTNGKTKTYEVEVCCSNLNYLKYGMLTRKNSKSAMQAGESSSQADAKTEQVEQSMFLQGERTDEKEIPSEQNIVYRGSWYGYIANDKSTSWSGNASNATSGNRAEFTVNFADKKITGTLTADNRQEATFTIDGNIKDNGFEGTAKTAESGFDLDQSNTTRTPKAYITDAKVQGGFYGPKAEELGGWFAYPGDKQTKNATNASGNSSATVVFGAKRQQPVR
What is the function of this protein?
Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host.  Acts as a TF receptor and is required for TF utilization.  Involved in the initial capture of TF.  Helps select only those TF molecules that can be used as an iron source and concentrates them on the cell surface, maintaining the iron-loaded status of the TF C-terminal lobe until its delivery to TbpA.
What are the official names of this protein?
Transferrin-binding protein B, TbpB, Surface lipoprotein TbpB, Transferrin-binding protein 2, TBP-2.
What is the protein family that this protein belongs to?
Belongs to the TbpB family. Isotype II subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Cell surface. Note=Requires Slam1 for surface expression in E.coli.