PharMolix/UniProtQA huggingface dataset:
Protein: SDHF3_MOUSE
Sequence: MPGKHVSRVRALYRRILLLHRALPPDLKALGDQYVKDEFRRHKTVGPGEAQRFLKEWETYAAVLWQQAEDSRQSSTGKACFGTSLPEEKLNDFRDEQIGQLQELMQEATKPNRQFSITESTKPQL
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.  May act together with SDHAF1.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 3, mitochondrial, SDH assembly factor 3, SDHAF3.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. SDHAF3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DCD_ECOLC
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDEGEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: CCA_LEVBA
Sequence: MQLEHLPEEFEMARPVLQTIEQAGYEAYFVGGSVRDTILGKEIHDVDIATSAYPDEIKHLFKRTVDTGIEHGTVMILDHGTGYETTTFRSESTYTDFRRPDQVTFVRSLAEDLKRRDFTINALAMKEDGTVIDLFDGLADLKHRQIRAVGDPQERFHEDALRMMRAVRFASQLNFTIVPETLAAMTSHAELLRKIAVERTQVELLKLLTGQAPQQGLTDLLTTGLWQYCPDFADHKVDLERLTAQLHQGASTDLTAWTLLTTSFGLETNAITTFLKHWKTANQTISAVQMTTKMAQHLLQGSLSTWQVYQCGEDQLMIANEAAVVLGATDRSRELVAQWQNLPIQTKKALAVTGRDLMQAGVQPGPQLGAILGDLEYQVVTGKLPNEKPALVAAVTD
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: DEFL_STAAR
Sequence: MAIKKLVPASHPILTKKAQAVIKFDDSLKRLLQDLEDTMYAQEAAGLCAPQINQSLQVAIIDMEMEGLLQLVNPKIISQSNETITDLEGSITLPDVYGEVTRSKMIVVESYDVNGNKVELTAHEDVARMILHIIDQMNGIPFTERADRILTDKEVEAYFIND
What are the official names of this protein?
Peptide deformylase-like, Polypeptide deformylase-like.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RISB_DESHY
Sequence: MMTYEGKLIAEGLKFGIVAARFNEFITNKLVGGALDALLRHGVAESDIEIAWVPGAFEIPLVAQKMAETKKYDAIICLGAVIRGATPHFDFVSAEVSKGVAHVGLETKLPVVFGVLTTDTIEQAIERAGTKAGNKGFDSAITAIETVNLLKMIQ
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: G6PI2_CLALE
Sequence: MATPALISETEAWKDLKAHLEGIKRTHLRELMGDTERCQSMMVEFDNIFLDYSRQQASPDTINKLYKLAEAAHLKQKIDRMYNGDHINSTENRSVLHVALRAPRNSAICSDGKNVVPDVWNVLDKIKDFSERVRNGSWVGATGKELKDVIAVGIGGSFLGPLFVHTALQTDPEASKNARGRELRFLANVDPIDAARNISGLNPETTLVVVVSKTFTTAETMLNARTLREWISSALGVAAVAKHMVAVSTNLPLVEKFGIDPNNAFAFWDWVGGRYSVCSAVGVLPLSLQYGFAVVEKFLQGAHNIDQHFSSAPFEKNIPVLLGLLSVWNVSFLGYPARAILPYSQALEKLAPHIQQVSMESNGKGVSIDGLPLPFESGEIDFGEPGTNGQHSFYQLIHQGRVIPCDFIGVVKSQQPVYLKGEVVNNHDELMSNFFAQPDALAYGKTPEELKKENVSEHLIPHKTFTGNRPCLSILLPTLDAYRIGQLLAIYEHRVAVQGFVWGINSFDQWGVELGKSLATQVRKQLHASRVKGEPVEEGFNFSTKTLLTRYLQATTDVPADPSTLLPNI
What are the official names of this protein?
Glucose-6-phosphate isomerase, cytosolic 2A, GPI, PGI3, PGI, Phosphoglucose isomerase, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_ACIAC
Sequence: MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLGTILMRSAGCCVNDVADRDFDRHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTNAATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIPMAFTAVGGAVPMLAAWLVLGNLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGLGWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HXK1_SPIOL
Sequence: MRKAAVGAAVVCTAAVCAAAAVLVRQRMKSSSKWGRVMAILKELDDNCGTPLGKLRQVADAMTVEMHAGLASEGASKLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVLRVKLGGKEKRVVEQEFDEVSIPPELMVGTSEQLFDYIAEALAKFVATESEGLHPEPNKQRELGFTFSFPVKQTSIASGTLIRWTKGFNIEDTVGEDVVAELTKAMLRKGVDMRVTALVNDTVGTLAGGRYYKEDVIAAVILGTGTNAAYVERASAIHKWHGPLPKSGEMVINMEWGNFRSSYLPLTEYDIALDEESLNPGEQIFEKMISGMYLGEIVRRVLYRMADEASLFGDTVPSKLKTPFILRTPDMSAMHHDTSPDLKVVASKLKDVLGIPNSSLKVRKIIVDVCDVIASRGACISAAGILGIIKKLGRDTLKQGENQKSVIALDGGLFEHYAKFRECMEDSLKELLGDEVAETIVIEHSNDGSGIGAALLAASHSQYLEEDES
What is the function of this protein?
Fructose and glucose phosphorylating enzyme.
What are the official names of this protein?
Hexokinase-1, SoHxK1.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Protein: ARMD3_DANRE
Sequence: MAQTEKKAGLLRRTSSSKKPLKEKVVLMYDEIFMKEDPTKNSPRFWDELFLMKVNLEYLEGKLESLDGDEFMKIKDNINSLFHHCVQALAEEHQIKVVNALQTLCALFRGVHQKNKSATGFDIINMLIGFDKAELRMKELMESLDSLLCGDGSESLKSLCLKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSDVSSRSQHGYDSVVLLALLVNYRKYESVNPYIVKLSIVDDEPTLDGLGMVIHHALTEYNRQYKEKEEENQGGFFSTLSSMVGSMFIADADEKLSVQTNEAILLALYEAVHLNRNFITVLAQSHPEIDMAATPATPVPASPTTPLGTTPPSLDLMNNPELPLDPNLQTSNLLITFLKYSSIVMQDTKDEHRLNSARLCLIILTCIAEDQYADAFLHDDNMNFRVNLHRMPMRHRKKAADKNIPCRPLVCAVLDLMVEFVVTHMMKEFPMDLYVRCVQIIHKLICYQKKCRVRLHYTWRELWSALINLLKFLLSNETGLLAKHNIFQLALQVVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQVFDNLYCMVLRVSTNAGQWKEPASKVTHALVNVRAIINHFNPKIESYAAVNHISQLSEDQVLEVVRSNYDTLTLKLQDGLDQFERYSEQPREAGFFKELVRSISLNVRKNVSLTTMSQDVLLKEFSSIS
What is the function of this protein?
May be involved in Golgi maintenance and protein secretion.
What are the official names of this protein?
Armadillo-like helical domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the ARMH3 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein. Cytoplasm.
Protein: YIDC_NEIMB
Sequence: MDFKRLTAFFAIALVIMIGWEKMFPTPKPVPAPQQAAQQQAVTASAEAALAPATPITVTTDTVQAVIDEKSGDLRRLTLLKYKATGDENKPFILFGDGKEYTYVAQSELLDAQGNNILKGIGFSAPKKQYSLEGDKVEVRLSAPETRGLKIDKVYTFTKGSYLVNVRFDIANGSGQTANLSADYRIVRDHSEPEGQGYFTHSYVGPVVYTPEGNFQKVSFSDLDDDAKSGKSEAEYIRKTPTGWLGMIEHHFMSTWILQPKGRQSVCAAGECNIDIKRRNDKLYSTSVSVPLAAIQNGAKAEASINLYAGPQTTSVIANIADNLQLAKDYGKVHWFASPLFWLLNQLHNIIGNWGWAIIVLTIIVKAVLYPLTNASYRSMAKMRAAAPKLQAIKEKYGDDRMAQQQAMMQLYTDEKINPLGGCLPMLLQIPVFIGLYWALFASVELRQAPWLGWITDLSRADPYYILPIIMAATMFAQTYLNPPPTDPMQAKMMKIMPLVFSVMFFFFPAGLVLYWVVNNLLTIAQQWHINRSIEKQRAQGEVVS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SELU_SHEPC
Sequence: MPSAIVAAEQYREIFLNQHPMMDVRAPIEFTRGAFPNSTNLPLMLDSEREKVGTCYKQFGQQAAIALGHSLVNGPIKQQRIEAWASYVKANPNAYLYCFRGGLRSQLTQQWLKEAGIEVPYIQGGYKAMRQYLIGVIEAAPTQQPLLSLSGMTGCGKTDFLLQRKEAVDLEGIANHRGSSFGKNIDPQPTQINFENQLAIALLRHQQDNHSCLLLEDESFLIGRSALPQSFYSAMQAAEILVLEEPDDTRLKRLRNEYVHKMYSGFCERLGLEAGFAAFSEYLLQSLMSIRKRLGGKQHQELQDLMQQALNQQISQNDTSLHLVWIHLLLHKYYDPMYQYQLQKKSERVLFKGSHQAMHEWLNNFKSTQ
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: KISHB_MOUSE
Sequence: MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKAAVIGTRLHAAVAIACIVMAFYVLFIK
What is the function of this protein?
Involved in the early part of the secretory pathway.
What are the official names of this protein?
Protein kish-B, Transmembrane protein 167B.
What is the protein family that this protein belongs to?
Belongs to the KISH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein.
Protein: ORR10_ORYSI
Sequence: MAVAIEAPFHVLAVDDSLPDRKLIERLLKTSSFQVTTVDSGSKALEFLGLHDHEDSPISTQSDQQEVGVNLIITDYCMPGMTGYDLLKKIKESSYLRDIPVVIMSSDNIPSRINRCLEEGADEFFLKPVRLSDMSKLKPHILKSRCKEHYQQEQHLQSNSESNNSSNPTSENSSSSTSTNSHKRKAVDEEILPHTIRPRHS
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ORR10, Type A response regulator 10, OsRR10.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
Protein: Y04G_BPT4
Sequence: MKQNKIEVYGIPDEVGRCPGCQSVTKLLKELNAPFTFYKVLTNNGKIEYDRPLIVSLAKRAGFTSLNIRYPVIFINDSRQKNIKHFKETLISLGYDRDIIED
What are the official names of this protein?
Uncharacterized 11.8 kDa protein in Gp55-nrdG intergenic region.
Protein: ATPG_UREPA
Sequence: MSLDAMKRKINSVQTTAKITNAMKLVATAKLKRQRDRLAAIKEYCHDYYDVIGLLLSVVDDVEFLKIPNAKDRTLYITINSTMGLAGSYNYNVNKLISKIVNETDITFTIGKKGHDFMRLSGRVDQVNTYLNLNDNDLTFDMSLQIAREALELYSQGEVNKICIIYTKFINAITFEVSVIDVLPFDKTALIKDHLAETIELAKDNIIFKPNKFELVKKILPTYIATVLYGSLIESKISENASRRNAMDAATKNAKALAENYKLIYNTLRQGKITREITEIVAGSDD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPS2_ARATH
Sequence: MDFISSLIVGCAQVLCESMNMAERRGHKTDLRQAITDLETAIGDLKAIRDDLTLRIQQDGLEGRSCSNRAREWLSAVQVTETKTALLLVRFRRREQRTRMRRRYLSCFGCADYKLCKKVSAILKSIGELRERSEAIKTDGGSIQVTCREIPIKSVVGNTTMMEQVLEFLSEEEERGIIGVYGPGGVGKTTLMQSINNELITKGHQYDVLIWVQMSREFGECTIQQAVGARLGLSWDEKETGENRALKIYRALRQKRFLLLLDDVWEEIDLEKTGVPRPDRENKCKVMFTTRSIALCNNMGAEYKLRVEFLEKKHAWELFCSKVWRKDLLESSSIRRLAEIIVSKCGGLPLALITLGGAMAHRETEEEWIHASEVLTRFPAEMKGMNYVFALLKFSYDNLESDLLRSCFLYCALFPEEHSIEIEQLVEYWVGEGFLTSSHGVNTIYKGYFLIGDLKAACLLETGDEKTQVKMHNVVRSFALWMASEQGTYKELILVEPSMGHTEAPKAENWRQALVISLLDNRIQTLPEKLICPKLTTLMLQQNSSLKKIPTGFFMHMPVLRVLDLSFTSITEIPLSIKYLVELYHLSMSGTKISVLPQELGNLRKLKHLDLQRTQFLQTIPRDAICWLSKLEVLNLYYSYAGWELQSFGEDEAEELGFADLEYLENLTTLGITVLSLETLKTLFEFGALHKHIQHLHVEECNELLYFNLPSLTNHGRNLRRLSIKSCHDLEYLVTPADFENDWLPSLEVLTLHSLHNLTRVWGNSVSQDCLRNIRCINISHCNKLKNVSWVQKLPKLEVIELFDCREIEELISEHESPSVEDPTLFPSLKTLRTRDLPELNSILPSRFSFQKVETLVITNCPRVKKLPFQERRTQMNLPTVYCEEKWWKALEKDQPNEELCYLPRFVPN
What is the function of this protein?
Disease resistance (R) protein that specifically recognizes the AvrRpt2 type III effector avirulence protein from Pseudomonas syringae.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.  Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is degraded by AvrRpt2.
What are the official names of this protein?
Disease resistance protein RPS2, Resistance to Pseudomonas syringae protein 2.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Not a peripheral membrane protein. Has the biochemical properties of an integral membrane protein without an obvious integral membrane primary structure.
Protein: IFF3_CANAL
Sequence: MQLFQNILVSIALLTQVVFAIEITENKVDRGTVTLNLSDITIYPGASWSIIDNAYTSFVGKLDVRDGAGLYISSTSHLLALQVSLTALLHSITNNGVVSFDSRISRTSSSYDLRGVSFTNNGEMYFAASGEFSSSTALTSASWTNTRLLSFYQNQRTSGTVSLGMPLGSITNNGQVCLNNQVYEQTTQIKGSGCFTANGDSTIYISNVLLAVSPKQNFYLTDKGSSMIVQAVSTTQTFNVYGFGEGNKIGLTIPLMGNLWNSAYAYDTTSGILTLRNLLLEQKFNIGTGYDPSKFQVVTDSGSGIPSTILGSVAYYGRVPERTLPKSCQIPCKPIPEAPGTTPTQYTTTITKTNTAGNTVTESGVVNVSTDKGGSWFTTTSMFPALSTAPSTATVFSSDTIMSTVEPDTTELASLTDIPIETSSVEELLSVMSNWEPSSAPTLSIETPVSSHHSSMQHSSFESSADINTVFSSESAFETASDYIVSTPSSISHSTMVPQSSVSALSVVSESLASAEPSFVVPSESFIFSASSAAPQPSSSTYSVSFTTQFETPSSAGPSLVTSVESNTELISSATQSSDIQTEFTSTWTTTNSDGSVVTESGIISQSGTSLTTLTTFQPATSLVVPPYSVIETEFTSTWTTTNSDSSVATESGVVSQSDTLLTTVTTFPPAPSAIVPEFTSPWKINTSIESSETLTVSASSYETVGESLAAATSSYLSSATVVVAPSESEINTSSSILNNEEIASAPVSDTTSIAEHHDGSLSMTTTEFVNSNSLPSSHSIVTATITSCNKSKCSESVVTYVSSVSCATITVGDSEKNSSIVGNNISSIVGDDVSNTQAITMATSTESATTLTSVSGAKPSVANDATNSVHTTDYTTATTGVQNGSSLSIPSDIPIEISDITPTDSSSSAVTISYENGSNKESIENIKYLTLVVFGLMMFM
What is the function of this protein?
GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
What are the official names of this protein?
Cell wall protein IFF3, Adhesin-like protein IFF3.
What is the protein family that this protein belongs to?
Belongs to the HYR1/IFF family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: HMDH1_GIBZE
Sequence: MASILLPKRFRGETAPAEKTTPSWASKRLTPIAQFISRLACSHPIHTVVLVAVLASTSYVGLLQESFFSTDLPTVGKADWSSLVEGSRVLRAGPETAWNWKAIEQDSIQHAGADADHLALLTLVFPDTHSAESSSTAPRSSHVPVPQNLSITPLPSTKNSFTAYSQDSILAYSLPYAEGPEFLAATQEIPSEDAVETETQHGREKKTWIMKAAKVNTQNSVVQWANNAWTEFLDLLKNAETLDIVIMFLGYIAMHLTFVSLFLSMRKLGSKFWLGICTLFSSVFAFLFGLIVTTKLGVPISVILLSEGLPFLVVTIGFEKNIVLTRAVMSHAIEHRRQIQNSKSGKGSPERSMQNVIQYAVQSAIKEKGFEIMRDYAIEIVILALGAASGVQGGLQHFCFLAAWTLFFDFILLFTFYTAILSIKLEINRIKRHVDMRMALEDDGVSRRVAENVAKSDGDWTRVKGDSSLFGRKSSSVPTFKVLMILGFIFVNIVNICSIPFRNPRSLSTIRTWASSLGGVVAPLSVDPFKVASNGLDAILAAAKSNNRPTLVTVLTPIKYELEYPSIHYALGSAINGNNAEYTDAFHHHFQGYGVGGRMVGGILKSLEDPVLSKWIVIALALSVALNGYLFNVARWGIKDPNVPEHNIDRNELARAQQFNDTGSATLPLGEYVPPTPMRTEPSTPAITDDEAEGLQMTKARSDKLPNRPNEELEKLLAEKRVKEMSDEELVSLSMRGKIPGYALEKTLGDFTRAVKIRRSIIARNRATSDLTHSLERSKLPFEKYNWERVFGACCENVIGYMPLPVGVAGPLVIDGQSYFIPMATTEGVLVASASRGCKAINAGGGAVTVLTADGMTRGPCVAFETLERAGAAKLWLDSEAGSDIMKKAFNSTSRFARLQSMKTALAGTNLYIRFKTTTGDAMGMNMISKGVEHALSVMSNEAGFDDMQIVSVSGNYCTDKKAAALNWIDGRGKGVVAEAIIPGDVVRSVLKSDVDALVELNISKNLIGSAMAGSVGGFNAHAANIVAAIFLATGQDPAQVVESANCITIMKNLRGALQISVSMPSLEVGTLGGGTILEPQSAMLDLLGVRGSHPTNPGDNSRRLARIIGASVLAGELSLCSALAAGHLVRAHMQHNRSAAPSRSTTPAPMTPVSFAMTNGPERSASTTSMSAAAIQRSKR
What is the function of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity).  HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity).  The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA.  The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1, HMG-CoA reductase 1, Ergosterol biosynthesis protein HMG1.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL28_ACIF2
Sequence: MSRVCKVTGKKPMAGNNVSHAHNKTRRRFLPNLQYHRFWVESENRWVRMRVSTKGIRTIDKKGIDVVLADLRAAGEKI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: BIG1_MOUSE
Sequence: MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKVETEKQSPPHGEAKAGSGTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMERERHRQQQHLLQSPVSHHEPESPHLRYLPPQTVDHINQEHEGDLEPQTHDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNDILYDGDYEEKPLDIVQSIVEEMVNIIVGDMGEGMAISASTEGNTGTVEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEISEVKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSLTGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMSVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPTSGEAEPPSPSAVSEKPLDAISQKSVDIHDSIQPRSSDNRQQAPLVSVSTVSEEVSKVKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCREALSYFLTLTSESHREAWTNLLLLFLTKVLKISDSRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGIVFQISQPPEQELGINRQ
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1 and ARF3.  Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP.  Involved in vesicular trafficking.  Required for the maintenance of Golgi structure; the function may be independent of its GEF activity.  Required for the maturaion of integrin beta-1 in the Golgi.  Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing.  Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.  Inhibits GAP activity of MYO9B probably through competitive RhoA binding.  The function in the nucleus remains to be determined (By similarity).
What are the official names of this protein?
Brefeldin A-inhibited guanine nucleotide-exchange protein 1, BIG1, Brefeldin A-inhibited GEP 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
Protein: DTD_PSEE4
Sequence: MKGLIQRVRGARVEVAGEIVGAIDNGLLALVAVEPEDTPEHADKLLHKLLNYRVFSDEQGKMNRSLKDIGGGLLLVSQFTLAADTRNGMRPSFSTAAPPALGAELFDYLLQRAQGQHPDVASGRFGADMQVHLVNDGPVTFMLQI
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_PROMM
Sequence: MASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWAEFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMAQQEFDAVVINDNLQVAVIELESLMGLSC
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PACK_BPCPT
Sequence: MRRAKLDKNATSNAVAYCSATGRHNLSATHASRLAFSVFSHPNVKAFLKSMEKETIDDMIMGRDELLSELTDIASTTIDDIVQIVHSSDNMMNVKRGRFIQDLSRSLLTT
What is the function of this protein?
This protein may possess the specific endonuclease activity required for cleavage at the pac site.
What are the official names of this protein?
Putative packaging signal terminase, PAC site terminase.
Protein: PA2CA_OXYSA
Sequence: NLLQFGYMIRCANGRSRPVW
What is the function of this protein?
Monomer (alpha chain): Snake venom phospholipase A2 (PLA2) that possesses a low level of presynaptic activity and the same high enzymatic activity than the heterotrimer.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 cannitoxin alpha chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.