PharMolix/UniProtQA huggingface dataset:
Protein: UREG_BURA4
Sequence: MNAPALSPARRTKKLPPLRVGIGGPVGSGKTTLLEMLCKAMRERYDLVAITNDIYTKEDQRLLTVAGALPEERIMGVETGGCPHTAIREDASINLEAVDRMLSRFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLDVMASDTKKMRGERPYVMTNLKALEGVADVVAFIEKKGLLMV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMAD_ASPFU
Sequence: MADIAEQLIEKLQTLETSIFEGQDATRQKLALAARKLFHTLETKEEKTMRLAIEEPVMFSVLQALIDTGLFEGWAAAGGGERDVTELAKLSKRDVEPELLRHQLRLMAANHIILETANDRYAPTPYALAIGDKSTKVAPALRIRTDHVAPCAMHWPDFLAKTNYRKPRDDKASCYIDTFPEKKSFFERCSANPVHQESFSSFMDVWAKGKRPWPEFYDTQALLDGADLSNGSPFVVDVGGHHGIDLMRVAEKHPDLPAGSLVLEDLPDVVGAVHLTTDKIRTVAHDLFEEGVEQPIKGARAYFMHAVLHDWSDETSVKILRQIAAVMKPGYSKVLINDIVIPSTGASCYQAAMDCLVLQASANERTEAVWSKVIKDAGLKLVKYYPDGRGYESVIEAELP
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:24568283, PubMed:23488861).  Within the pathway, the O-methyltransferase af390-400 acts as a 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase that methyltes the hydroxylated position C-6 of 5-dehydro-6-demethoxy-6-hydroxyfumagillol to yield 5-keto-fumagillol (PubMed:24568283).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
O-methyltransferase af390-400, 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase, Fumagillin biosynthesis methyltransferase, Fma-MT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: PEPB_ECODH
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVVWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y207_ENCCU
Sequence: MNIAHISEPHEINEQHHIKNQLHWRTSFNCLAPLISIALPMLIHFIFEEDRFEENPFLRLITVLLPLSYSVIQYSALLHTNWKESTKPEDTTHKALHYILNLLLLTFVVISIFSITVFTLDKWDYAASFFYSIVLPSLLIPPVYLFSTSCSFISGQIGFRDTGTDIFIDILILICDIVNVVLVYKESEFLSVFCGLIPGQTGFTGTGTNILINTLVSVFDIVNRVLVYKESKYYLYSAIILFVFILIRILTEKHCPSGKNSLLTAPWRIAVFVSILILAILVFTLIVHVSIKVLNDHLNLPGELNSLRLPKADE
What are the official names of this protein?
UPF0328 protein ECU02_0070.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: NUOB_FRATN
Sequence: MGIGNENKGFITASADALINWVRTGSLWPVTTGLACCAVEMMHAGAARYDLDRFGIVFRPSPRQSDVLIVAGTLCNKMAPALRQVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALVYGIIQLQNKIIRKDTIARK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IBPA_SALTY
Sequence: MRNFDLSPLYRSAIGFDRLFNLLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIELERVIPEANKPRRIEIN
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YS014_HUMAN
Sequence: MPDASLGSLGITWCFLESPLEVSSGRFGLARLLGSQDHGDDPAERGRTATDAWGPSRWGQSPGNGGGYCDASPPSALAPGDRAWALPASPSSGAPASQHCCLEKAGTRTKASPVWGRDGNTWN
What are the official names of this protein?
Putative uncharacterized protein LOC400692.
Protein: ARSB_STAAN
Sequence: MTTLATLIFLVTLLFVLWQPKGLDIGITALTGAFIAVITGVVSFSDVFEVTGIVWNATLTFVSVILISLILDKVGLFEWSAIHMLHASKGNGLKMFVYIILLGAIVAAFFANDGAALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNIISADYFHVGFVRYFSRMIIPNLFSLLASIIVLWLYFRKAIPKTFDDNNIKHPKDAINDLKLFKISWIVLVILLFGYLISEFTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTILGMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGIIITIPVLFITLIGLYLTLIIF
What is the function of this protein?
Involved in arsenical resistance.  Thought to form the channel of an arsenite pump.
What are the official names of this protein?
Arsenical pump membrane protein, Arsenic efflux pump protein.
What is the protein family that this protein belongs to?
Belongs to the ArsB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUDL_SALPB
Sequence: MDTSRLTLDHFLSRFQLLRPQMTHETLNQRQAAVLIPVVRRPQPGLLLTQRAIHLRKHAGQVAFPGGAVDSTDASLIAAALREAQEEVAIPPQAVEVIGVLPPVDSVTGFQVTPVVGIIPPNLPWRASEDEVSAVFEMPLAQALQLGRYHPLDVYRRGNSHRVWLSWYEHYFVWGMTANILRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: SYT_ZYMMO
Sequence: MAEKIRITLIDNSEREVLQGTTTTQIAASISTSLAKKALAARFNGQMIDLSQPLLEDGRLEIITAENEAEALELVRHDYAHILAEAVQKLFPGTQITFGPVTDDGFYYDFAPKDRPFTEEDLPLIEAEMRKIIAQNNALVREVWERDKLISLWESQGEKFKAEWAKELPEGQELTIYRAGEWFDMCRGPHLPSTGKLDPKAFKLTRVSGAYWRGDQNNAMLSRIYGTGWLNAKQLKAHLERLEEAQKRDHRRLGQEMDLFHLQQEAQGSVFWHPNGYTIWLQLEAYLRRRMKNANYKEVKTPQLMDAALWEASGHWGKFRENMFVVPDEIPSTDPDKPVLSGKGNLMALKPMNCPAHIQIFKQGIRSYRELPLRMLEFGCCHRNEAHGALHGLMRVRQLTQDDAHIFCTAEQIVTETKDFVNLLDSIYRDLGFTSYAVKLSLRPELRAGDDELWDNAENGLRSALEQVGITDYEELPGEGAFYGPKLEFHLTDAIGRTWQCGTLQLDYVLPERLDASYVAEDGSRKRPVMLHRAIIGTFERFIGILIEHHAGRFPLWMAPVQAVVATIVSEADSFAESVVEKMKAAGLRVVSDIRNEKINYKIREHSLTKVPNILVVGKREAEEGKVAIRKLGSRDQIILSVDEAIALLLEEATPPDLK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNUA_BRUSU
Sequence: MKNLHSLFLASAFLAGFCGSSLAGEREGVVVSIKPLHSIVSAVMQGVGKPKLIVQGAGSEHVYSLKPSDAEAIEHAKVIFWAGPSMETFLDKPIDTLGEGAKVVALGDAKGLTKLKFREGGPFEAHDHGHGGSHEEEHDAHGSGDHDHAAEVAEEGHEHHHHGEYDLHFWLDPQNGKILAADIAKTLGESDPEHAAQYEKNAKAYGEKLDALTREVAAELKPVKDKPFIVFHDAYQYFENRFGMKAAGSITVSPEKAPGAARIQQIHDKIKSLGATCVFSEPQFEPKLVKTVVDGTKARTGVLDPLGAELKDGPDLYPQLIRNLANSLKDCLSK
What is the function of this protein?
Involved in the high-affinity zinc uptake transport system.  Required for survival and normal growth under low Zn (2+) concentrations.  Also required for virulence and intracellular growth in host cells (By similarity).
What are the official names of this protein?
High-affinity zinc uptake system protein ZnuA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL32_FRATH
Sequence: MAVQQVKKSRSKRDMRRSHDSLTNPTLSTDKSTGELHLRHHVSPNGFYKGRKVVDTKSED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: HOG1_CRYNJ
Sequence: MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDQLSGTSVAIKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTIASENTLRFVQSLPKREKVPFSTKFPNADPVSLDLLEKMLVFDPRTRISAAEGLAHEYLAPYHDPTDEPVAAEVFDWSFNDADLPVDTWKVMMYSEILDFHNLGDISQNEAEGPVTGEVPAAPAS
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes.  Also involved in response UV radiations and mediates the sensitivity to fludioxonil, an agricultural fungicide.
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.
Protein: NDK_XYLFA
Sequence: MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRDRPFFNALVEFMISGPVMIQVLESENAVARHRELLGATNPKDAALGTIRADFAESIEANAAHGSDSVENAAIEVAYFFAATEIILR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM138_HUMAN
Sequence: MLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQMLFVFQRLAAVLYCYFYKRTAVRLGDPHFYQDSLWLRKEFMQVRR
What is the function of this protein?
Required for ciliogenesis.
What are the official names of this protein?
Transmembrane protein 138.
What is the protein family that this protein belongs to?
Belongs to the TMEM138 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes to vesicles en route to the base of cilium.
Protein: ZNF14_MACFA
Sequence: MNSVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKKWEDQDIEDDHRNQGRNRRGHMVERLCESRKGSKCGETTSQMPNVNINKETSTGAKPHECSFCGKDFMHHSSLNRHMRSHIGQKPNEYQEYEKQPCKRKAVGKTFSYRHCVRKHERTHTGGKPYECKQCGKAFIYYQPFQRHERIHAGEKPYECKQCGKTFIYYQSFQKHAHTGKKPYECKQCGKTFICYQSFQRHERTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFQAHVITHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRMHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKAFRFSSSLQRHERTHSAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLCGKAFSFSSSLREHEKIHTGNKPFECKRCGKAFLRSSQIRLHERTHTGEKPYQCKQCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERSHTGEKPYECKQCGKAFISSSHFRLHERTHMGEKA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 14.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TUFT1_MOUSE
Sequence: MNGTRNWCTLVDVHPESQTAGSVDILRLTLQSELTGDELEHIAQKAGRKTYAMMPGHSSGHSLASELVESHDGHEEIIKVYLKGRSGDKMTHEKNIDQLKSEVQYIQEARNCLQKLREDISSKLDRSPGDPLRQQEIQVVLEKPNGFSQSPMTLYSSPPEVDPSMSEDVESLKKTVQELLVKLREAERRHQSDRVAFEVTLSRYQREAEQSNVALQREEDRVEQKAAEIEELQRRLLGMEAEHQALLVKVREGEMALEELRIKNADCQTEREKSAALEKEVAGFREKIHHLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQVSHGNFSTQARAKTENLGSVRISKPPSPKPMPLIRVVET
What is the function of this protein?
Involved in the mineralization and structural organization of enamel.
What are the official names of this protein?
Tuftelin.
What is the protein family that this protein belongs to?
Belongs to the tuftelin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites.
Protein: THII_STRPZ
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAITVRSDRDRTHVSLNGTDYQPIVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQNLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRMR_ECO24
Sequence: MPSTPEEKKKVLTRVRRIRGQIDALERSLEGDAECRAILQQIAAVRGAANGLMAEVLESHIRETFDRNDCYSREVSQSVDDTIELVRAYLK
What is the function of this protein?
Repressor of the frmRAB operon.
What are the official names of this protein?
Transcriptional repressor FrmR.
What is the protein family that this protein belongs to?
Belongs to the FrmR/RcnR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTRC_HUMAN
Sequence: MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWISSSTYKDRNEEYRRQFTHLPDTERLIADYACALQRDILLQGRLYLSENWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIVTESEKFFFTSFGARDRSYLSIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMENLSLSIEDVQPRSPGRSSLDDSGERDEKLSKSISFTSESISRVSETESFDGNSSKGGLGKEESQNEKQTKKSLLPTLEKKLTRVPSKSLDLNKNEYLSLDKSSTSDSVDEENVPEKDLHGRLFINRIFHISADRMFELLFTSSRFMQKFASSRNIIDVVSTPWTAELGGDQLRTMTYTIVLNSPLTGKCTAATEKQTLYKESREARFYLVDSEVLTHDVPYHDYFYTVNRYCIIRSSKQKCRLRVSTDLKYRKQPWGLVKSLIEKNSWSSLEDYFKQLESDLLIEESVLNQAIEDPGKLTGLRRRRRTFNRTAETVPKLSSQHSSGDVGLGAKGDITGKKKEMENYNVTLIVVMSIFVLLLVLLNVTLFLKLSKIEHAAQSFYRLRLQEEKSLNLASDMVSRAETIQKNKDQAHRLKGVLRDSIVMLEQLKSSLIMLQKTFDLLNKNKTGMAVES
What is the function of this protein?
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity).  Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity).  Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity).  In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity).  At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).
What are the official names of this protein?
Protein Aster-C, GRAM domain-containing protein 1C.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single- pass membrane protein. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS).
Protein: CLPX_FRATT
Sequence: MAKILYCSFCGKSQQEVKNIISGRDGNICNECVSKCAEKIRSTGSTSAEDISFEKLPKPVEIKKYLDDYIIGQDNAKKVLSVAVYNHYKRITSNLTKDDDTELKKSNVLLIGPTGSGKTLFAQTLAKLLNVPFAIADATTLTEAGYVGDDVENIIVRLLQNADFDVAKAQKGIIYIDEIDKIARKSESTSITRDVSGEGVQQALLKLIEGTVSSVPPKGGRKHPNQDMIQVDTSDILFICGGAFAGIEKVIKHRMDKVSIGFNSDVIQQKNSLDSDKLMQKIESEDLTRFGLIPELIGRLPIVTVLNELKEEDLVRILTEPKNALIKQYIKLFKFDNVNIEFTDQALVEIAKKAITKKTGARGLRTILENVLLEVMFHIPSSEDIEKVIINDKVILEQQEPILATKTQQQKQLKDII
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: UXAB_PECCP
Sequence: MQTLNRRNFPGRQHPDRVIQFGEGNFLRAFVDWQLDLLNEHTDLDAGIVIVRPIDSDFPPALDTQDGLYTTIIRGLNEQGEAVREPRLIRSVNREINVYRQFDEYLALAHDPNIRFVFSNTTEAGISYHADDSLSDAPPVSFPAKLTRLLYERFCHFDGAADKGWVLLPCELIDYNGVALKELVLRYAAQWKLTPTFTAWLNDHNTFCSTLVDRIVTGYPRAEVEALQQEMGYQDTFWDTAEHFYLFVIQGPQWLAEELRLNKLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAFLAGLDTVGESMDDALIGKFVEKTIAEEIVPVLDLPHDELTSFAQAVLSRFRNPFIQHQLLSISLNGMTKFRTRILPQLLTYRERHGELPARLTFALAALIAFYRGERSGEGDTLQTYPLQDDAHWLERYSTLWAGVKENTVSLAELVNVVLRDADHWEQDLTQVPGLAAQVTEQLQTIVERGMRAAVEGYC
What are the official names of this protein?
Altronate oxidoreductase, Tagaturonate dehydrogenase, Tagaturonate reductase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family. UxaB subfamily.
Protein: AZOR_YERPE
Sequence: MSKVLVLKSSILATSSQSNQLADFFVEQWQAAHAGDQITVRDLAAQPIPVLDGELVGALRPSGTALTPRQQEALALSDELIAELQANDVIVIAAPMYNFNIPTQLKNYFDMIARAGVTFRYTEKGPEGLVTGKRAIILTSRGGIHKDTPTDLVVPYLRLFLGFIGITDVEFVFAEGIAYGPEVATKAQADAKTLLAQVVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: MUTS_ACIB5
Sequence: MNSAEIMADLSNHTPMMQQYLKVKKDYQHALLFYRMGDFYELFFEDAHLAAKLLGITLTHRGKANGNPIPMAGVPYHSAEGYLARLVKAGRTVAICEQVGEVTGKGPVERKVVRILTPGTLTDDALLTSYQSSNLVALCIHQNQIGFALLDLSAGIFKVQQQDYKPEQLPIELARLMPSEILIDEDLVDPNIIEQIKKHLDCPVTKRPNVDFNLNNAQKTLCDQFSVSTLSGFGLDPLPLAKAAAAALIHYAKETQKTALPHIRSILLEQSSDFIALDPITRRNLEIIEPLFEHGTSLFQLVNDCQTAMGGRLLSRTLMQPVRDTALLDARLDAIEQLIQGYHESPVRLVLKEIGDIERVLSRVALGSARPRDLVQLRHACAQIPFLRNALAPVVQAKKSKLLGQLDQELGDFKSLHQHLMAAIVENPPVLLRDGNVIAEGYDAELDELRQIRDHAGQFLIDLEIKERERTGISTLKIGYNRVSGYYIELTRAQAEQAPADYIRRQTLKNAERYITPELKSFEDKVLSSESRALAREKALFEALLENLRENIAHLQMMSSAIAQIDVIANFAHQARLNNWARPEFTPETGIKIQGGRHPVVEALSKAPFTPNDTFLDVQHRMAIITGPNMGGKSTFMRQTALISLLAYCGSYVPARAAKLGPIDRIFTRIGSADDLSTGKSTFMVEMTETSQILHHATNQSLVLMDEVGRGTSTYDGLSLAWACVVDLTKRVKCLCLFATHYFELTELGSEPGIDNYHVTAQELNGNLILLHKVQQGPASQSHGLQVAKLAGIPANVIKEAQKRLRILEKQQQQHLQTSVQSDLFATLDSEVTPSTQVIEKVIEVEVSSPALDLLKQIEVDNLTPRQALEQLYELKAALNS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TRUB_STAA8
Sequence: MYNGILPVYKERGLTSHDVVFKLRKILKTKKIGHTGTLDPEVAGVLPVCIGNATRVSDYVMDMGKAYEATVSIGRSTTTEDQTGDTLETKGVHSADFNKDDIDRLLESFKGIIEQIPPMYSSVKVNGKKLYEYARNNETVERPKRKVNIKDIGRISELDFKENECHFKIRVICGKGTYIRTLATDIGVKLGFPAHMSKLTRIESGGFVLKDSLTLEQIKELHEQDSLQNKLFPLEYGLKGLPSIKIKDSHIKKRILNGQKFNKNEFDNKIKDQIVFIDDDSEKVLAIYMVHPTKESEIKPKKVFN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y007_SIFVH
Sequence: MVKMSIQLNEFQKKALQSFLMSDKNLLITAPTGTGKSFLAMLMAMETKSRVVYTVPLRALALQLNDDFHNKVAPLVNGYADSVALTSEVYEEDPENLEERVIFTTYEKADAIFRRHYPWTDRIETLIIDEIHNIGDKERGKAIENLIAYAMNEGIRIVAMSATIPDVNKIAEIIDAEIIKTDERPIPLYKAVKIGNKLYFEDGDVIELKEDFIKKMVRKNKVVMIFTSTRKKAEELYMIYDRKFQNKVAFFHAGLDAETKLRLLEETRQGKYNIIVSTTALSQGVNFPFYAVVFDDLKLPIIEYGRFTGWKQITPIEFDQICGRAGRPGYDEEGLCIIEATDIRQAEKLKRTYFNTSYGTITGHHVLEDFLLALISKYIYAKPDRIMEATKHTISFRNISEELVKEKLEELKNAKLIGEDGTGYFVTLYGRAVAESYFDVKDAITYHDVLTKNNVKEEEIINAILENENVLNASKGENVNIIFNSWIKGVDEKTIVKATKNMTLNDLNKLVQTLSWQTYGVYRITKALGKKELADKLRLLFLEIRYGVPASALALVQLPGIGRKRAIELMRNGIHNKTELCSQKEISKKIIGEKMVKVLCK
What are the official names of this protein?
Putative helicase 7.