PharMolix/UniProtQA huggingface dataset:
Protein: SYT_CYTH3
Sequence: MIKITLPDGSIREYEKGITSMGIALSISEGLARNVLAAKVNGEIWDASRAITSDSTVQLLTWNDTEGKSTFWHSSAHLLAEALEALYPGTKFGIGPAIETGFYYDVDFGDRAFSQDDFENIEKKVLELAKQKNAYIRKEISKKDAVAYFTDKQDPYKLDLLEGLSDGSITFYKQGAFTDLCRGPHIPDTGFIKAVKLMSVAGAYWRGDEKSKQLTRIYGVTFPKQQELKDYLTILEEAKKRDHRKLGKELELFAFSEKVGMGLPLWLPKGALLRERLENFLKKAQVRAGYQPVVTPHIGNKQLYVTSGHFDKYGKDSFQPIFTPHEGEQFLLKPMNCPHHCEIYKTKPRSYKDLPIRFAEFGTVYRYEQSGELHGLTRVRGFTQDDAHIFCRPDQVKEEFLKVIDLVLYVFKVLGFNDYTAQISLRDPENKDKYIGEDEQWQKAEQAIIEASAEKGLSTVTELGEAAFYGPKLDFMVKDALGRKWQLGTIQVDYQLPNRFELEYTGSDNQKHRPVMLHRAPFGSLERFIAVLIEHVAGNFPLWLSPDQIAILPISEKFNDYAQDVYDRLLVKDIRGFIDNRDEKIGKKIRDTEVKKVPFMLVIGEKEVNEGKIAIRKHGGEDLGSMLVEDFIQYFESEIAKQLAV
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_PYRAB
Sequence: MVNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_BURO1
Sequence: MKIHEYQGKEILRKFGVAVPRGKPAFSVDEAVKVAEELGGPVWVVKAQIHAGGRGKGGGVKVAKSIEQVREYANQILGMQLVTHQTGPEGQKVNRLMIEEGADIKQELYVSLVVDRISQKIVLMGSSEGGMDIEEVAEKHPELIHKVIVEPSTGLLDAQADDLAAKIGVPAASIPQARAILQGLYKAFWETDASLAEINPLNVSGDGKVTALDAKFNFDSNALFRHPEIVAYRDLDEEDPAEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPDLKAILVNIFGGIMRCDVIAEGVIAGSKAVNLNVPLVVRMKGTNEDLGKKMLADSGLPIISADSMEEAAQKVVAAAAGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: FL2_TOBAC
Sequence: MDPEAFSASLFKWDPRGAMPPPTRLLEAAVAPPPPPPALPPPQPLSAAYSIKTRELGGLEELFQAYGIRYYTAAKIAELGFTVNTLLDMKDEELDDMMNSLSQIFRWELLVGERYGIKAAIRAERRRLEEEELRRRGHLLSDGGTNALDALSQEGLSEEPVQQQEREAVGSGGGGTTWEVVAAAGGGRMKQRRRKKVVAAGREKRGGASAEEDEETEEGQEDDWNINDASGGISERQREHPFIVTEPGEVARGKKNGLDYLFHLYEQCRDFLIQVQNIAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDEEASNALRRAFKERGENVGAWRQACYKPLVAIAARQGWDIDTIFNAHPRLAIWYVPTKLRQLCHSERSNAAAAAASSSVSGGGGGGDHLPHF
What is the function of this protein?
Probable transcription factor that act to specify determinacy in the progenitor cells for both flowers and leaves.
What are the official names of this protein?
Floricaula/leafy homolog 2, NFL2.
What is the protein family that this protein belongs to?
Belongs to the FLO/LFY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRHE_PENBI
Sequence: MPTKGDYQPPKDGILSKLPESAVPYGELLRIHRPLGYYLNISPYVVGVAYTAAISPVTLPSTFLLGRLVILSLWGFCIRSAGCAWNDLIDMDIDRQVSRTKLRPLPRGAVSPSGAALLAAFMFGCGGSLLLLLPSQCAFEAAIVVFFALLYPFGKRFSDHPQLILTNIAWAIPMAMSSLDMSPLDFPIPTLAMSFSIASVIVMIDIVYACQDAEEDKKVGARSMAVRYMEITDQIAYGLFFSGTLSLLVGGILRGLGFPFLIFSVGGHFLGFLRFLRASLGKGAKSALVESQAKSSCLLATMLLVFGLCFEYCVRL
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
Polyprenyl transferase prhE, Paraherquonin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1999_STRSV
Sequence: MDLAKIGAETRQIVLDVLDKAALVEGDIFVLGLSSSEVVGGHIGQNSSLEVGQVIIKTILDILEEKGIFLAVQGCEHLNRALVVEKALADKKDLEIVNVLPTLHAGGGGQLAAFQYMKDPVEVEFIVAQAGLDIGDTAIGMHVKHVQIPIRPILKELGAAHVTALASRPKLIGGARAAYTEDKIRKG
What are the official names of this protein?
UPF0340 protein SSA_1999.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: TUSA_PROMH
Sequence: MNAQFDDATKTLDTLGLRCPEPVMLVRKTIRNMAQGETLLVIADDPATVRDIPGFCRFMEHDLLQQETQATPYRYLIRKKEGQL
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_CAMFF
Sequence: MISLKDAIKLSSSDIVKLRKNLKDKIKDNRQLGAYIEQLTNSDISDEYAGVPIAIKDNIQVKNWSITSCSKILQGYVAPYHATVVEKLLKAGLAPFGRTNMDEFAMGSTTESSFYGKTLNPLDHTRVPGGSSGGSAAAVSAGLAIAALGSDTGGSIRQPAAFCGCVGFKPTYGRVSRYGLGAYSSSLDQIGPITRSVEDAALLYDIIAGHDPKDSTSSNLENISTSDKLNSDRKLTIAVIKNYVDGASQDVKDSLYKVVDKLKEAGHNIIYKDLSNSKYDIAAYYIIATAEASANLSRYDGVRYGRRADSNSLGQMYSKTRGEGFGVEVQRRMLLGTFVLSSGYYDAYYIKAQKARAFIKLEYEEILNEADIMLMPVAPSVAYKFGELSDPLSAYLSDIYTIGVNLAGLPAITVPVQSDKNGLNISAQLIGGAWKEQDVLDAAFGLEKLVKGN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: PP185_ARATH
Sequence: MQSRALSRLRSYYKRSSVFPSSDNDRSVQLFNLVRSIYSSSSRPRVPQPEWLIGELCKVGKIAEARKLFDGLPERDVVTWTHVITGYIKLGDMREARELFDRVDSRKNVVTWTAMVSGYLRSKQLSIAEMLFQEMPERNVVSWNTMIDGYAQSGRIDKALELFDEMPERNIVSWNSMVKALVQRGRIDEAMNLFERMPRRDVVSWTAMVDGLAKNGKVDEARRLFDCMPERNIISWNAMITGYAQNNRIDEADQLFQVMPERDFASWNTMITGFIRNREMNKACGLFDRMPEKNVISWTTMITGYVENKENEEALNVFSKMLRDGSVKPNVGTYVSILSACSDLAGLVEGQQIHQLISKSVHQKNEIVTSALLNMYSKSGELIAARKMFDNGLVCQRDLISWNSMIAVYAHHGHGKEAIEMYNQMRKHGFKPSAVTYLNLLFACSHAGLVEKGMEFFKDLVRDESLPLREEHYTCLVDLCGRAGRLKDVTNFINCDDARLSRSFYGAILSACNVHNEVSIAKEVVKKVLETGSDDAGTYVLMSNIYAANGKREEAAEMRMKMKEKGLKKQPGCSWVKVGKQNHLFVVGDKSHPQFEALDSILSDLRNKMRKNKNVTSDAEEAEFLVI
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g35030, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: END4_VIBPA
Sequence: MTNMKNKFGNKLIGAHVSAAGGVDQAPLRAREIGANAFALFTKNQRQWVAKPLEAKTISAFKANCKMLGFGAEHILPHDSYLINLGAPEAEKLDKSRAAFIDEMERCNQLGLTLLNFHPGSHLKKVSEQECLATIAESINLAHKTVPDVVAVIENTAGQGTNLGWKFEHLAEIIEQVEDKDRVGVCIDTCHTFTAGYDLRTKEDCERTFAEFDRIVGMHYLRAMHLNDSKVEFASKVDRHHSLGKGEIGWDCFEYIAKDSRFDGIPLILETIDPDIWQQEINTLRQFHLAAINNQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: SYH_CERSK
Sequence: MAKDKASRRPRAETPKGFRDYFGADVTERKAMLDAVAEVYHRYGFDPLETSAVETVEALGKFLPDVDRPNEGVFGWQDEDGDWLALRYDLTAPLARVAAQFRNDLPSPYRRYAMGPVWRNEKPGPGRFRQFYQCDADTVGSASVAADAEICAMLSDALEVVGIPRGDYIVRVNNRKVLNGVMEVAGVLDPSDPAKFEAERGIVLRAIDKIDRLGKTGVRALLGAGRKDESGDFTKGAGLSDEQAEVVMGFMAAKRDTGAATAARLRELVGASTLGCEGVQELETIAELLDAQGYGPDRIVVDPSVVRGLGYYTGPVFEAELTFEILDEKGRKRQFGSVAGGGRYDDLVKRFTGQSVPATGVSIGVDRLLAALRAKGRAGAEAQGPVVVTVMDRDRMGDYMAMVGELRRAGLRAELYLGNPKNFGNQLKYADARKSPVAVIQGSDEATRGVVVLKDLVLGAQIAAGASLEEWKSRPAQVEVPRADLVRAVQDMLS
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_BURPS
Sequence: MSIKPPSALSELVEALRALPGVGPKSAQRIAYHLMQHDREGAERLGRSLLFATEHLRHCEKCNTFTEAQVCEVCSDPERDPALLCVVETPADQIMLEQTMTYRGLYFVLMGRLSPLDGIGPKEIHFDRLVRRASDGIVKEVVLATNFTNEGEATAHYLGQTLKARGLAVTRLARGVPVGGELEYVDAGTIARAMLDRRTL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: FBK35_ARATH
Sequence: MAMKKKISTSSIMPDWSQLPEELLHIISTHLEDHYFDAVHARSVCRSWRSTFPFPSSLLRQSYSLPAFPLESKDLCCTLEKVPLFLFRVLTPPDAADASSEYFLGGLGQDKSNDHVELPSPLQCSVKVNVPGTEPILMNMLDCQIIPLGHKYRLMIGCNPEEYSAAFLPLNEQGGGGEFVALLDCTDLFLVLRSTEMRWIRLEKPSTASCKELFTFRGRFYATFFNGDTFVIDPSSLEATPLTPHIDSNFLVPSGNEELFLVKTDFLRCRVSRLDEEAAEWVEVSDLGDRVLFLGGHLGNFYCSAKELPHGCGLTGDSILFTVGSRNVTYPYKYGVHTNKRKAEDNINCWRSSRENRVLFRNRYDPVLSFRVER
What are the official names of this protein?
F-box/kelch-repeat protein At2g24250.
Protein: MDHG_ORYSJ
Sequence: MEDAAAAARRMERLASHLRPPASQMEESPLLRGSNCRAKGAAPGFKVAILGASGGIGQPLALLMKMNPLVSVLHLYDVVNTPGVTADISHMNTGAVVRGFLGQPQLENALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLCEGIAKCCPNAIVNVISNPVNSTVPIAAEVFKKAGTYDPKRLLGVTTLDVVRANTFVAEVLGLDPRDVNVPVIGGHAGVTILPLLSQVNPPCSFTSEEISYLTTRIQNGGTEVVEAKAGAGSATLSMAYAASKFADACLRGLRGDAGIVECSFVASQVTELPFFASKVRLGRCGIEEILSLGPLNEFERAGLEKAKKELAESIQKGVAFINK
What are the official names of this protein?
Malate dehydrogenase, glyoxysomal.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: YGFB_PSEAE
Sequence: MSTQNSAYSAFSSLLAEAAMPVSPAELHGHLLGRVCAGAGFDEAAWQHAAAELLGGAPGERLKAALSGLLGMVRQDFSAGEVAVVMLLPDDETPLAQRTEALGQWCQGFLAGFGLTAREGSLTGEAEEVLQDMAAIAQVQGQLEDSEDGETDYMEVMEYLRVAPLLLFAECGKPLEPAPKPSLH
What are the official names of this protein?
UPF0149 protein PA5225.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: LEUD_CAMJ8
Sequence: MQKFIIHKGIACPLEYANIDTDQIIPKQFLLAVSKQGFGKHLFHDLRYLDDKESVLNMDFNLNKKEYQNSSILVSFENFGSGSSREHAPWALVDYGIRAIIAPSFADIFKNNALGNGLLTIELAKDEVLEIVDELKKSQDKNIEISLLEKRVFFKDKIFSFDLDDFHRICLLEGLDNIALTLKHEAQIKAYEKNSKSFLV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TILS_CHAVU
Sequence: MYNFINLIDRIDHILVERKLLLSKQKILIAVSGGQDSIFLLNLLLQLRFHWEWEIGIVNCDHMWNQFSQTASLYVSQLACQMNLNYYQCISPSFYRKEEKARSWRYKLFQRIAYLHDYTIIITAHTASDRVETLFYNLFKGSGLHGLHSLTWKRQIYKKRIHLVRPLLSTTRGELSQIFKQIQIPLYLDSTNLNVKIYRNRIRYQLLPYLRLFFNRNLDRSIAQFAEILHSESLFLETLTQILRNKIEIINKNQKILDIQFIRVIPFAIQRRIIKQFLEHQSIYSFDFCHIEKIRIISNIIIYKSDIYLPGGNRLTISKKYILLCSKISF
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, chloroplastic, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACV1B_HUMAN
Sequence: MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
What is the function of this protein?
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B).  Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.  Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals.  Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase.  The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B.  Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.  Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4.  This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.  Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.  ACVR1B also phosphorylates TDP2.
What are the official names of this protein?
Activin receptor type-1B, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SRY_SHEEP
Sequence: MNRTVQSYASAMFRVLKDDVYSPAVVQQQNTFAFGKTSSLCTDNHSANDQRERGENVRESSQNHVKRPMNAFIVWSRERRRKVALENPKLQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRKAKRPQKSLAADSSILCNQMDAETLHPFTYRDDCAKTTHSQMESQLSRSQSVIITNSLLQKEHHSSWTNLGHDRVTLASRISADFPFYQSLEPGLSCAYVQY
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: HIS6_METHJ
Sequence: MTLTRRIIPCLDIKDGRVVKGTNFLGLRDAGDPVELACRYNEQGADEVVFLDITASRENRGMIIDVIQRAADELFLPLTVGGGIRTLDDVQKTLRAGADKVSINTSAVQNPALISEAAQAFGTQCVVVAIDVKRRTSPEPGKTMIPLPDQSSCWYEVVTHGGSQPTGIDAIAWAKEAENRGAGEILLTSMETDGTKEGFDIPITSAISESVGIPVIASGGVGTFDHFYEGFVYGKADAALAASVFHYGEMTIADVKDYLSKKGIAIRPHTQ
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_SHIBS
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFHHSG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: HUTU_YERE8
Sequence: MTAQNRFRDTEIRASRGTKLTAKSWMTEAPLRMLMNNLDPEVAENPKELVVYGGIGRAARNWECYDKIVESLTHLNDDETLLIQSGKPVGVFKTHSNAPRVLIANSNLVPHWANWEHFNELDVKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDFDDALARIKKYTSAGKAVSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWSWEEYRRRAQSEPVLVVNAAKTSMAEHVEAMLAFHHMGIPTFDYGNNIRQMAQDMGVTHAFDFPGFVPAYIRPLFCRGVGPFRWAALSGDAEDIYKTDAKVKELIPDDEHLHHWLDMARERISFQGLPARICWVGLGQRAKLGLAFNEMVRTGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDDAAERIARVLHNDPATGVMRHADAGYDIAINCAQEQGLNLPMIAATQGRKA
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_JANMA
Sequence: MQDQDKYAEQAASIEDPVTAEAASATTPTLEEQLAASQLLVQELQDSFLRAKAEVENFRRRAQEDVTRAHKFAIEGFAEMLLPVKDSLEMALQVETPSVESLKEGVEMTLKQLNAAFEKNRLLEIKPQQGDKLDPMKHQAMSLVPADQEPNTVVNTLQKGYLIADRLLRPALVTVAQEK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_BRUO2
Sequence: MSEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFNGDVTIKWYEDGVTNVSYNCIDRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVFAGFSPEALAGRIVDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQEVASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTALRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYNVVGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQEGVADGNLCISDSWPGQMRTVYGDHKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHHSVSEAAVVGYPHPIKGQGIYCYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDESGALGDTSTLADPGVVDDLIENRQNKK
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.