PharMolix/UniProtQA huggingface dataset:
Protein: Y090_METJA
Sequence: MMVMVELLSPANDLTCLKTAIDYGADAVYCGLKELNMRANAKNFTREELIEGIKYAHDNNKKVYLCTNTVVYENDLKKVEEILDFANSAEVDAVIVSDLGTMQLANELGLRVHASVQCNVTNSLTAKFYSKFAKRVILSRELTLNQIKEIRENLKKDKVDLELEGFVHGALCVAISGRCFLSSYLFGRHANCGDCLQPCRRKWKLINEHHDGTYEIVCEGKYLLSPKDLCMIEHIPELMEVFDSFKIEGRAKNADYVMRTTKIYREAIDSVLDGSYYDKLEYFKKELQKVYNRSYDTGFYFRDINKNHDFQYEIEGNASKYRKIEIGRVVNFYKKVSVAEIELWHDLKIGDTILIIGKTTGCVEEVVKSMQINHKDVEIAKKGERVGVKLNHLVREGDRVYLLKETI
What are the official names of this protein?
Uncharacterized protease MJ0090.
What is the protein family that this protein belongs to?
Belongs to the peptidase U32 family.
Protein: SSU72_ASPFU
Sequence: MAHDPRLSSAGTATPNPPPPPPPPPPEPSTTGTGETQAAEPSAPAQSSDSFKLKFCTVCASNQNRSMEAHLRLSTAPSPFPVISFGTGSLVRLPGPSITQPNVYNFNTTSYSQMYDELLAKDERLYRNNGLLNMLDRNRNLKWGPERFQDWVPGMPRVDHVSKGDKGALGTEGGTVDVIITCEERCWDAVVDDLMNKGAALNRPVHVFNVDIRDNHEEALVGGKAILELATRLNDAATQERKIHGAEGWENGNGEARRSFDERVPEILASWQEKWPNLPALWTLAWL
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Ssu72 is required for 3'-end formation of snoRNAs (By similarity).
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase ssu72, CTD phosphatase ssu72, Suppressor of SUA7 protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASPD_METBF
Sequence: MLKIGVIGCGFIGGQICRAIDKGVINAELYALSDSSESKVLELTTCLKRYSPASMTIEELLQNVDFVIESASQKAVRLIVPQALEAGRDVMVMSVGALADEELRKRLFRLAEQNNCKLYFPSGAVAGIDGINSASAAEILSVTLTTRKPPMGLAGAPHVEALGIELETIEKETLLFEGPASEAVKAFPANVNVAATISLAGIGFERTKVRVIADPTLSRNVHEITVEGEFGKLSTRVENLPSPENPKTSYLAALSAISTLKKILSPVQIGT
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: RL2_FRASN
Sequence: MGIRRYKPTTPGRRGSSVADFVEITRDHPEKSLVRPLHSKGGRNVHGRITTRHQGGGHKRAYRIIDFRRDKDGVPAKVAHIEYDPNRTARIALLHYVDGEKRYILAPVKLHQGDMVSSGVGADIKPGNALPLRNIPTGTVVHAIELRPGGGAKIARSAGASVQLVAKDGPYAQLRMPSGEIRNVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGRRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVNPKGRPEGRTRRTKKSSDALIVRRRKQNRRR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SEPF_BACC2
Sequence: MSWSKVKYFFFDTPEEKEAAQYGYEKEQTDMKKQQDPPEQQDVTFPKAQPKQNVVSIETAKQSSKVVLLEPRTYSEAQGIADHLKGRRAVVINLQRMSTDQAVRIVDFLSGTVYAIGGDIQKIGPKTFMCTPENVDIVGAISELFGEEEETNIKRW
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: GLSA_RHOPA
Sequence: MSNQLLDRVVAEIADEMAQRADRGEVASYIPELARVDPKAFGLAVIGADGHIAAAGDADVPFSIQSISKVFTLTLALGKAGDRLWRRVGREPSGSAFNSIVQLEHERGIPRNPFINAGAIAVTDLILSGHQPREALGEILRFMQFLAGDSSIAIDEAVAKSEQRTGFRNAALANYMKSFGVLDNPVEYTLGVYFHHCAIAMSCRQLAMAGRFLAHNGQNPSTGLNVVSSERARRINALMLTCGHYDGSGEFAYRVGLPGKSGVGGGILAVAPGRASIAVWAPGLDAAGNSHLGRVALEGLTKRMGWSIFGV
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: GLGA_PSEF5
Sequence: MISAVLDTQGDHPQQQAGDRAAPSVPVPGNKTVLPLARPNPNRKRVLFVTSEIADLVKTGGLGDVSAALPRAMAHLHDVRVLIPGYPQVLHSENPIHIIGELGGHAALPACKIGRMDMPDGLVIYVLICPELYEREGTPYGANNGRDWPDNHIRFARLGLAAADIAANLAQIHWCPDLVHAHDWPAGLAPAYMHWRGQRTPTLFTIHNLAYQGVVSLASCPELGIPEHALQQEGMEFYGKLSFLKAGMAYASHITTVSATYAQEITTPAFGCGLDGFLASKTQQGLLSGIPNGIDESWDAATDAHLLTPFSIGDWDGKAANAAHVRQMFGLDASSGPLFAVVSRLVYQKGLDLTEAVAEFIVQSGGQIAIIGRGEPEEEQSMRALARRFPGRIGVHIGFNETDARRMFAGSDFLLMPSRYEPCGLSQMYAQRFGSLPVARNTGGLADTIENGVTGFLFDESTVASYQEALTRAFKVFAYPALLNAMRCRAMAAPFNWCKAVEPYAELYEQLVAKALGQAARQ
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: GLYA_PELUB
Sequence: MSSEKNYLNENYKSFFDDSLSVTDPELHKAISDELKRQQQHIELIASENIVSQAVLEAQGSVLTNKYAEGYPGKRYYNGCEHVDVAENLAIERLKKIFDCKFANAQPHSGAQANGAVFLALLNPGDTFMGMSLNSGGHITHGLKISMSGKWFNPIGYDVDKESELIDYDNVEKLALEHKPKLIICGGSAYSRVIDFKRFREIADKVGAYLMVDMAHFSGLVAGKGYPNPCEHAHVVTSTTHKVFRSARGGIILTNHEDLAKKFNTAVFPGYQGGPLMHVIAGKAAGFLEALRPDFKDYIKSVLANAKILSETLKNNGFKIYSGGTDTHLMLVDLRPFNVKGNAAAESLSNANITCNKNGIPFDSEKPMITSGIRLGTQAATTRGFGLKEFEKVGELITKVVKGLSENPEDNGKIEEEVRNEVIDLTSNFPIYKNLK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ1_ARATH
Sequence: MRRFNWVLRHVQARRTFDSAIGLRQGSQKPLFERYIHATGINNSSARNYYDVLGVSPKATREEIKKSFHELAKKFHPDTNRNNPSAKRKFQEIREAYETLGNSERREEYDKLQYRNSDYVNNDGGDSERFRRAYQSNFSDTFHKIFSEIFENNQIKPDIRVELSLSLSEAAEGCTKRLSFDAYVFCDSCDGLGHPSDAAMSICPTCRGVGRVTIPPFTASCQTCKGTGHIIKEYCMSCRGSGIVEGTKTAELVIPGGVESEATITIVGAGNVSSRTSQPGNLYIKLKVANDSTFTRDGSDIYVDANISFTQAILGGKVVVPTLSGKIQLDIPKGTQPDQLLVLRGKGLPKQGFFVDHGDQYVRFRVNFPTEVNERQRAILEEFAKEEINNELSDSAEGSWLYQKLSTG
What is the function of this protein?
Plays a continuous role in plant development probably in the structural organization of compartments.
What are the official names of this protein?
Chaperone protein dnaJ 1, mitochondrial, AtDjB1, AtJ1.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family. B/II subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IFNB_MACFA
Sequence: MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSSFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQPQQFQKEDAALTIYEMLQNIYAIFRQDLSSTGWNETIVENLLANVYHQIDHLKTILEEKLEKEDFTRGKFVSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFFFINKLTGYLRN
What is the function of this protein?
Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.  Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity).  Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.  Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor.  Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss.  IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
What are the official names of this protein?
Interferon beta, IFN-beta.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_XANC5
Sequence: MTQTNGFDALHAHAQRLRGAAIPALLAAEPQRPTQYARQVGPLYFNFARQKYDRAALDALFAIARERDLAGAFQRLFRGEQVNVTEQRAALHTALRGDLTDAPVASEAYATAAEVRQRMGALIQQLEATEVTDIVSVGIGGSDLGPRLVADALRPVSGARFRVHFVSNVDGAAMQRTLATLDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLPMWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAVWNRNLLGSATHAVMTYDQRLALLPSYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGTDVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHVALMANVLAQTEALANGQDSSDPHRSYPGGRPSTVILLDALTPQALGGLISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLLPALKGEAADVADPVTRELLSKLRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_ACTPJ
Sequence: MKVSPRRRARECAVQALYSWYVSQNSVEEVELSFVTDQDMNGVDLPYFRKLLRGTVLYVEAIDNDLRPFLDRAEDEVDPIERTILRLSAYELKYELDVPYKVVINEGIEVAKVFGSDDSHKYINGILDKLAPALGRK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: ISPA_BUCAI
Sequence: MHFFHLYERYKHRINQKLFYTLNQLPFQKSSLLKAMKYSVFSGSKRLRSSLIYSTGDVFKVNITTLDVISTAIEFIHSYSLIHDDLPCMDNDNFRRGKISCHVKYGESTSLLAGDALQSLAFNILSNSFMPNVSNLKRIKMISELSYSIGSSGMCMGQNLDLEAEKKDVNLSELEIINLYKTSFLMRSAVRLVYFSSNNFSKSILSILDLFSISIGLAFQIQDDILDFKKDSVKTDNKKIIKKHTYPLIIGLDESRKKIKQLHKKSFLALNSLKKKISIPTY
What are the official names of this protein?
Farnesyl diphosphate synthase, FPP synthase, (2E,6E)-farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_COXB1
Sequence: MTHSKRWLEEHEKDPYVKRAKKEGYPSRAAYKLLEIHQKYKLFKPSMNVIDLGAAPGGWSQVAKDLVGPKGVVIAIDLLPIQSMLDVIFIQGDFNEPEIFNQLEAIVAKKTLTGQVDLVISDMAPNISGIKNVDQSRSLHLVELAWDCAQKLLARGGTFLVKVFQGPGVDRFLINLRPYFNQVKFLKPSASRSRSSEIYILAGEFLGYNQRV
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFPP_MYCS2
Sequence: MDIIPPRLKEPAYRIYEMRLRHELVRSKAQLPRHIAVLCDGNRRWARDAGYDDVSIGYRKGAAKIAEMLRWCQAAGIEMATIYLLSTENLQRDPDELTALIEIITDVVEEICAPYNKWSVRTVGDLELLGDEPARRLREAVESTTTKGANFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQLIEAVTVDGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTARHRRFGK
What is the function of this protein?
Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP).  Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.
What are the official names of this protein?
(2Z,6E)-farnesyl diphosphate synthase, Short-chain Z-isoprenyl diphosphate synthase, Z-FPP synthase, Z-FPPS, Z-Polyprenyl diphosphate synthase, Z-isoprenyl diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family. Z-FPP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: DAAA_LISMF
Sequence: MKVLVNNHLVEREDATVDIEDRGYQFGDGVYEVVRLYNGKFFTYNEHIDRLYASAAKIDLVIPYSKEELRALLEKLVAENNINTGNVYLQVTRGVQNPRNHVMPDDFPLEGVLTAAAREVPRNEQQFVQGGPVITEEDVRWLRCDIKSLNLLGNILAKNKAHQQNALEAVLHRGEQVTECSASNISIIKDGVLWTHAADNLILNGITRQVIIAVAKKNGIPVKEADFTLTDLREADEVFISSTTIEITPVTHIDGVQVADGKRGPITAKLHQYFVEEIVQACGELEFAK
What is the function of this protein?
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine.  The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.  The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism.  This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components (By similarity).
What are the official names of this protein?
D-alanine aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, DAAT, D-aspartate aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: BLH1_YEAS6
Sequence: MLPTSVSRSLYLKTFRSHLLRAPQIVLKRMSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTRLQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFELSQAYLFFYDKLEKANYFLDQIVSSADQDIDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPKDLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSIIVTLREQMQREIFRLMSLFMDIPPVQPNEQFTWEYVDKDKKIHTIKSTPLEFASKYAKLDPSTPVSLINDPRHPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKKTGVMDIELWNYPAIGYNLPQQKASRIRYHESLMTHAMLITGCHVDETSKLPLRYRVENSWGKDSGKDGLYVMTQKYFEEYCFQIVVDINELPKELASKFTSGKEEPIVLPIWDPMGALAK
What is the function of this protein?
The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells.  Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid.  Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin.  Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.  Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities (By similarity).
What are the official names of this protein?
Cysteine proteinase 1, mitochondrial, Bleomycin hydrolase, BLM hydrolase, Homocysteine-thiolactonase, HTLase, Hcy-thiolactonase, Leucine aminopeptidase 3, Y3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: DPO3_LISIN
Sequence: MTAKEEEKQERFQLLMTQIGLQDVTTYEEFTKDAKIEKLVADKKNKTWQFHLHVPQIFPAALFHMMDVGMKRAFSQIAETEMQIVPENQTINETLIQEYWNLIVEPIGKQSPMIGKLLMEQKPTFKEPHFIEVAVHNDMEEATIQQRFQAKIIENYGKAGFPRLAMKMHMLDQSETDEYKAFAQAKQEEDQKKAAEAVQVMQKRQAEGQNGSANAAPLTGPFQIGYKIKDDEEIKRLGDVYDEERRITVQGLIFATEIRELRSGRSLLQFKITDYTSSMIIKMFSRDNEDAAMFQNLKKGMWVKVRGSVQNDTFVRDLIMMAQDINEIAGVKRLDTAEEKRAELHLHSPMSQMDATSSVDSLFKQAADWGHKAIAITDHSVAQSFPEAYGAGQKYGLKVIFGIEANLIDDGVPIAYNDQHIALEDATYCVFDVETTGLSAVYDTIIELAGVKMKNGEIIDKFEAFIDPGHPLSATTINLTGITDDMVKGSDPIDVVLKQFREWSGDDILVAHNASFDMGFINTAYEKVGLEKAKNAVVDTLELARFLYPHFKNHRLNTLTKKFNIILEQHHRAVFDAEATAYLAWKLIKDAKEMHDIEFHDSLNDYMGEGDAYKRARPFHATIYAQTDVGLKNLFKLITMSNINYFYRVPRIPRSQLKKMREGLIIGTACSQGELFEAMMQKGMQAAEKVAEFYDFIEVQPKPVYAPLIERELVRDEKALEEILKNIVRVGEKTGKPVVATGNVHYKDPVDKIYRKILIHSQGGANPLNRAELPDVHFRSTDEMLKEFAFLGEEKAKEIVVTNSNLVVDWMDDLKPIKDELYTPKIDGAEDEVRNMSYGMAHQLYGEKLPEIVEARLEKELKSIIGHGFAVIYLISHKLVKKSLVDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYLCPNCKDSEFFDDGSVGSGFDLPDKDCPHCGTPYQKEGQDIPFETFLGFKGDKVPDIDLNFSGDYQPVAHAYTKEIFGEDYVFRAGTIGTVAEKTAFGYVRNYERDMNMTIRGAEVDRLVAGCTGVKRTTGQHPGGIIVIPDYMDVYDFTPVQFPADATDSEWKTTHFDFHSIHDNVLKLDILGHDDPTAIRMLQDLSGIDPKTIPTDDPDVMKLFGSTESLGVKPADIDSKTGTLGIPEFGTRFVRQMLEQTKPTTFSELVQISGLSHGTDVWLGNAEELIKNKTCELPDVIGCRDDIMVFLIYQGLESSLAFKIMESVRKGKGLTEEMEEAMIANKVPLWYIESCKKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLYFYATYFTVRADDFDLTSMVNGKEAVKATMKEVNDKGMEASTKEKNLLTVLEIANEMLARGFHFQKVDLYKSSADEFIIDGDSLIPPFNAIPSLGTNVAKQIVAARENGEFLSKEDLQQRGKVSKTIIQYMDDQGCLEGLPDQNQLSLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_ECOL5
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: EFTU_MYCA9
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPDLNEASAFDQIDNAPEEKARGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDMVDDEELLELVEMEVRELLSSQDFDGDNAPVVRVSALKALEGDAEWGKTVADLMDAVDESIPDPVRETEKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEDVEIVGIKDTTTKTTVTGVEMFRKLLDQGQAGDNVGLLVRGVKREDVERGQVVVKPGTTTPHTEFEGSVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTDISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_VIBA3
Sequence: MTAQNIDGKLISQTVRSEVAARVKARTQAGLRAPGLAVVLVGEDPASQVYVGSKRKACEEVGFVSKSYDLPATATEDELLTLVDQLNEDPEIDGILVQLPLPAGIDSTQVLERITPEKDVDGFHPYNVGRLAQRMPKLRSCTPKGIITLLDRYNIDLRGKHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLEGHVRQADVVVVAVGKPNFIPGAWIKKGAVVVDVGINRLESGKLVGDVEYDVAKESASFITPVPGGVGPMTVASLIENTMIACEQFHSK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CISH_HUMAN
Sequence: MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.  Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation.  May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS.
Protein: DIAA_ERWT9
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAALTVVQSLLNGNKILSCGNGTSSANAQHFAASMINRFETERPSLPAIALSADNVLLTAIGNDRLHEEIYAKQVRALGHTGDILLAISTRGNSRDIVKAVEAAVTRDMTIVALTGHDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQEV
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: RECN_AQUAE
Sequence: MLGRLYIQNFFFIRDVEVEFERGLNVITGETGTGKSMTISAIEFLMGKQGDYPEGTAVELELLGEEEIILRREVKKGRSRYYVNGKGASKSTVLELLEGKISLQGQNEFINLFREDFQRKLLDTFANLNDKVKELEKVYNSLRKKEQELFEFLRKKEELIQKKDYLEFRVREVEEIGISSEEYEELKNKANLINNLEKVKKAVGESLYKLLEGENSVYEILGEIRKNLAKVESYSGKFSELIEKIANLEEEVYELYNSLKEEMPEISEEEVNEINEKLFRIQRLEEKYKKSFPEILKEVEEIKEELSNLNSVDFKEEELREEVEKLREEYDKLAEEVSRDRRKKAEDLEERIEEILKELNLERAKLKVEIKESEPTKYGKDKIEFLFSSYGKDFKPLEEVASGGELSRLFLALSLILPASETYVFDEVDAGISGETSFKVAKFLKELSKKMQVIVITHSAPLCAAGDKNFKTEKKFLGDIPYIVVRELSEEEKVEEVARLMGMKSEKTLEGAKELVEAFK
What is the function of this protein?
May be involved in recombinational repair of damaged DNA.
What are the official names of this protein?
DNA repair protein RecN, Recombination protein N.
What is the protein family that this protein belongs to?
Belongs to the RecN family.
Protein: COPC_PSEUB
Sequence: MLLNRTSFVTLFAAGMLVSALAQAHPKLVSSTPAEGSEGAAPAKIELHFSENLVTQFSGAKLVMTAMPGMEHSPMAVKAAVSGGGDPKTMVITPASPLTAGTYKVDWRAVSSDTHPITGSVTFKVK
What is the function of this protein?
Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA.
What are the official names of this protein?
Copper resistance protein C.
What is the protein family that this protein belongs to?
Belongs to the CopC family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GCSH2_PSESM
Sequence: MSNIPAELRFAESHEWARLEADGTVTVGISDHAQEALGDVVFVELPEIGKVFAAGDVAGVVESVKAASDIYSPVAGEVVEVNEALGDSPESLNSEPYSAWIFKVKPASAEADLAKLLDAAGYKGAIGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein 2.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.