PharMolix/UniProtQA huggingface dataset:
Protein: CPSF5_RAT
Sequence: MSVVPPNRSQTGWPRGVNQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7.  Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing.  The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA.  Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function.  Binds to chromatin.  Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 5, Nucleoside diphosphate-linked moiety X motif 21, Nudix motif 21, Nudix hydrolase 21.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. CPSF5 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Protein: MIAB_MYCSJ
Sequence: MTQQAANALPPVARTYQVRTYGCQMNVHDSERLAGLLEDAGYRRAADGADADVVVFNTCAVRENADNKLYGNLSHLAPRKRSEPQMQIAVGGCLAQKDRDAVLRRAPWVDVVFGTHNIGSLPTLLERARHNRAAQVEIAEALQEFPSTLPAARESAYAGWVSISVGCNNTCTFCIVPSLRGKEVDRRPGDVLAEIQTLVDQGVLEVTLLGQNVNAYGVSFAADERLREDPRMWQSAPHRNRGAFAELLRACGRIDGLERVRFTSPHPAEFTDDVIEAMAETPNVCPALHMPLQSGSDRILRAMRRSYRAEKYLGIIDRVRAAIPDAAITTDLIVGFPGETEEDFQATLDVVAASRFSSAFTFQYSKRPGTPAADMPGQLPKAVVSERYQRLIELQERISLEENQAQVGRTLELLVATGEGRKDAATARLSGRARDGRLVHFAPGAAADEPLARRAFDQVRPGDVVTTTVTGAAPHHLIADGALLTHRRTRAGDAHAAGLRPRTGVGLGIPGVGAPAPAPVTTGCAL
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_HORSE
Sequence: VQLSGEEKAAVLALWDKVNEEEVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKVKAHGKKVLHSFGEGVHHLDNLKGTFAALSELHCDKLHVDPENFRLLGNVLVVVLARHFGKDFTPELQASYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SYK_STRPZ
Sequence: MSNQHIEELNDQQIVRREKMMALAEQGIDPFGKRFDRTANSAELKEKYADKTKEELHELNETAIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDSVGEDNYEIFKKADLGDFIGVEGEVMRTDMGELSIKATKLTHLSKSLRPLPEKFHGLTDIETIYRKRHLDLISNRESFDRFVTRSKMISEIRRYLDGLDFLEVETPVLHNEAGGAAARPFVTHHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADYLDIMNLTEGIIQHAAKAVKGDGPIDYQGTEIRINEPFKRVHMVDAIKEVTGVDFWPEMTVEEAIALAKEKQVPLEKHFTSVGHIINAFFEEFVEETLVQPTFVFGHPVEVSPLAKKNPEDTRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATGIDYDFVEALEYGMPPTGGLGIGIDRLCMLLTNTTTIRDVLLFPTMKP
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC1_PROMD
Sequence: EVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVSHVWYLKGIPSYVAILLDIPLRDVEQIVYFNCYVVLDVGDHKDLKYKQLLTEDEWLEIEDEVYAEDSTIENEPVVGIGAEALKQLLEDLDLNQIAEELREEITNSKGQKRAKLIKRIRVIDNFLATNAK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: K1C10_BOVIN
Sequence: MSVRYSSSKQYSSSRSGGGGGGGSSLRISSSKGSLGGGYSSGGFSGGSFSRGSSAGGCFGGSSSIYGGGLGSGFGGGYGSSFGGSYGGSFGGGYGGGGFGGGSFGGGSFGGGLGGGFGDGGLISGNQKITMQNLNDRLASYLDKVRALEESNYELEVKIKEWYEKYGNSRQREPRDYSKYYQTIDDLKNQIFNLTTDNANILIQVDNARLAADDFRLKYENEVTLRQSVEADINGLRRVLDELTLTKTDLEMQIESLTEELAYLKKNHEEEMRDLQNVSTGDVNVEMNAAPGVDLTELLNNMRSQYEQLAEKNRRDAEAWFNEKSKELTTEINSNLEQVSSHKSEITELRRTIQGLEIELQSQLALKQSLEASLAETEGRYCVQLSQIQSQISSLEEQLQQIRAETECQNAEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGSYGGGRGYGGSSGGGGGGYGGGSSSGGYGGGSSSGGGHGGSSGGSYGGGSSSGGGHGGGSSSGGHKSTTTGSVGESSSKGPRY
What is the function of this protein?
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).  Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 10, Cytokeratin VIB, Cytokeratin-10, CK-10, Cytokeratin-6B, Keratin-10, K10.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cell surface. Cytoplasm.
Protein: PSAK_GALSU
Sequence: MLIAVSTNIIFIVVNTICVILGKYSVQNKKNESYSIANINLAELLASMSLGHIISSATVLGLKSLNLIQ
What are the official names of this protein?
Photosystem I reaction center subunit PsaK, PSI-K, Photosystem I subunit X.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HNRH2_MOUSE
Sequence: MMLSTEGREGFVVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA
What is the function of this protein?
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.  Binds poly(RG) (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein H2, hnRNP H2, Heterogeneous nuclear ribonucleoprotein H', hnRNP H'.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: THIG_PROM1
Sequence: MQKTNKFLKIGTKEFKSRLLVGTGKYSSLEVMQKSLINTKCEIVTVAVRRVQGLEHGHKGLMESIDWKRIWMLPNTAGCSNAEEAIRIAKLGRELAKLAGQENNNFVKLEVIPDKKYLLPDPIGTLKAAEQLVKEGFTVLPYINSDPLIAKQLEEIGCATVMPLGSPIGSAQGIRNAANIAMIIAESRIPIIIDAGIGVPSEAAQALEMGADGVLINSAIALAENPILMAQAFSKATEAGRDGYLSGRLKENPLASPSSPLEGVISNN
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_LIMF3
Sequence: MLKPLGDRIVLKAQEEEQTVGGIVLASNAKNKPTTGVVVAVGQGRTLDNGQVVAVAVKEGDKVLFDKYAGNEVEYDGETYLVVHEKDLVAVVD
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_BARHE
Sequence: MVNLTIKREKKKIPRAFVVGTPIHHSKSPKIHNFWLKQYDLQGEYLAQEVTSEEFRDFLTSLKRRGFCGGNVTLPHKQEAFHLANYKDDVATMIGAVNTLWYEGDKLCGTNSDAYGFSANLDDSAPDWMGETALVFGAGGAARAILYALKKRGFERICLVNRTKQRAESLAEHFGKPVEVCDWYKAHEILYQADLIVNTTSVGMINSNEKESTSFFCDFHKTKTTALVTDIVYTPLVTPFLQRAKAHGLRTVDGLGMLLHQAVLGFERWFGIRPRVTKALRATILQDMGEKRG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: P2C13_ARATH
Sequence: MILSQTMVAEAEIRVLDVKCHISAPKDQKNFQIDEVRVSESVRAEISGSAETPRFGSGMSCVTTTIGESASDFIPTIRSGSFADIRSRETMEDEHICIDDLSAHLGSYNFSVPSAFYGVFDGHGGPEAAIFMKENLTRLFFQDAVFPEMPSIVDAFFLEELENSHRKAFALADLAMADETIVSGSCGTTALTALIIGRHLLVANAGDCRAVLCRRGVAVDMSFDHRSTYEPERRRIEDLGGYFEDGYLNGVLAVTRAIGDWELKNPFTDSSSPLISDPEIGQIILTEDDEFLILACDGIWDVLSSQNAVSNVRQGLRRHGDPRQCAMELGKEAARLQSSDNMTVIVICFSSVPSSPKQPQRRRLRFCVSDEARARLQAMLAGE
What are the official names of this protein?
Probable protein phosphatase 2C 13, AtPP2C13.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: LPTN_ECO57
Sequence: MNILHICVTSKWFNIDNKIVDHRP
What are the official names of this protein?
Tryptophanase operon leader peptide.
Protein: VP2_POVBA
Sequence: MGAALALLGDLVASVSEAAAATGFSVAEIAAGEAAAAIEVQIASLATVEGITTTSEAIAAIGLTPQTYAVIAGAPGAIAGFAALIQTVTGISSLAQVGYRFFSDWDHKVSTVGLYQQSGMALELFNPDEYYDILFPGVNTFVNNIQYLDPRHWGPSLFATISQALWHVIRDDIPAITSQELQRRTERFFRDSLARFLEETTWTIVNAPINFYNYIQDYYSNLSPIRPSMVRQVAEREGTHVNFGHTYSIDNADSIEEVTQRMDLRNKESVHSGEFIEKTIAPGGANQRTAPQWMLPLLLGLYGTVTPALEAYEDGPNQKKRRVSRGSSQKAKGTRASAKTTNKRRSRSSRS
What is the function of this protein?
Viroporin inducing perforation of cellular membranes to trigger virus progeny release.  Forms pores of 3 nm inner diameter.  VP4 is expressed about 24 hours after the late structural proteins and is not incorporated into the mature virion (By similarity).
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP4]: Host nucleus.
Protein: CWC25_MOUSE
Sequence: MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEREAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHRKHKHRSSSSGGSSSEDEQSQARSQKKMANSFPVLSKVPGYGLQVRDSDRNRGLQGSLGEQRAIKNNSRSRSSSPPRHASKKSTKEERPRDRRSRSPSRRSRSPRPSKPHTSKVNRKERDSPSPKKEAYQRRHASGYTRKLSAEELERKRQEMMENAKWREEERLNTLKRHAREDEREHRLERLDSRSGKFLHRMKLESASTSSLEDRVKRNIHSLQRTSVALEKNFMRR
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC25 homolog, Coiled-coil domain-containing protein 49, Spliceosome-associated protein homolog CWC25.
What is the protein family that this protein belongs to?
Belongs to the CWC25 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TOLB_SHEB8
Sequence: MRILAKWLALAVLLCTTPAKAALDIVITEGVDAARPIAVMPFVWQGPGAAPQAIADVVMSDLVRSGTFKPLDELGLPQRNIGTVAQFQANSWSSVGAEALVLGTVKPYGTDQYLVSFDLIDLVKAQNQALKGPVSATEFLMDSRQTVISAAQFRQYGHRISDIVYEKLTGIRGAFLTRISYVVVNHTQKAPYQLMVADYDGVNEQMLLRSPEPLMSPTWSPDGRRLAYVSFENKKAEIFVQDLYTQVRTKVSSFPGINGAPAFSPDGKSLAITLSKDGQPEIYIIDIATKAIKRITNHYAIDTEPSWYPDGKSLIFTSERGGRPQIYRVELSSGKVSRETFEGEWNLGGSITPDGRSMIFVNRTNGKFNIARMDLSTRFMQVLTSTRLDESPSVAPNGTMVIYGTTYQGKQVLAAVSTDGRFKARLPAGQGEVKSPSWSPFL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SEY1_PODAN
Sequence: MNGHFAAIGNGPTAKQYDHGIQVIDEDKSFNTNLNDYLTETHVAESGFNYHLISVFGSQSTGKSTLLNHLFGTQFSVMSETERRQTTKGIWLSKNKRDSANGSPMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDRQSQTRSLLFFVIRDFVGNTPLENLRTTLITDLSKIWSSISKPQGLEDSKIEDYFDFAFSALPHKIYQPEKFLAEVDRLGARFTTGHRSTKDQEFGGGVFLPEYHRRIPADGLSVYAGGVWDQIVNNKDLDLPTQQELLAQFRCDEIAREVLVGFDTVIAPLEEQQVEAIRLGKPAAVLADLGAQGAGAREKCIKAFETQASRYHKGVYTMKRGELESKIDTRLKALYQAQLTAAHKAGVAAFSEAVSGAVKAGQKAGGSYEFAEIVAKQKAKTLQIFKTEAKSLSIPGVAWSNFKPQYKLFEKELDEVSARLRKEEMRRLAIRVERWVRSRLGDAIGLEFNKLGSGRGGSVSPEGGEKPATEKDLWDRVWNAFIGIVKEAETRFAERAKSFEASPEEVEVGLWRLRRKSWVALREKIEEEVMESNILMKLRENFEDKFRYDEDGVPRIWRPTDDIEGIYTKARESTLGLVPLLSRFRLSETYAPPDLPAFIGVQPAGVEPEDEEDLLPIGGIDEEEGKSLEEETTVLGESKRQDLVVRFKKMADGVYVEAKRSAIGGITQVPLYFYVILLILGWNEILMVLRNPFLILLILVMGGGTYIAYSLNLLGPMMQMSNAAFNQAVDIGKDRLRDFLVNNETARQALAVPARQMGADISLDRLDSRGKKAQDISDDDDI
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: NAC20_ORYSI
Sequence: MGEQQQQVERQPDLPPGFRFHPTDEEIITFYLAPKVVDSRGFCVAAIGEVDLNKCEPWDLPGKAKMNGEKEWYFYCQKDRKYPTGMRTNRATEAGYWKATGKDKEIFRNHHMLIGMKKTLVFYKGRAPKGDKTNWVMHEYRLADASPPPPPSSAEPPRQDDWAVCRIFHKSSGIKKPVPVAPHQVPAAANYQQQQQMAMASAGIIQVPMQMQMPSMSDQLQMLDDFSTTASLSLMAPPSYSTLPAGFPLQINSGAHPQQFVGNPSMYYHQQQQMDMAGGGFVVSEPSSLVVSPQDAADQNNNAADISSMACTMDAAIWKY
What is the function of this protein?
Transcription factor that acts redundantly with NAC26 to regulate the expression of genes involved in the biosynthesis of starch and storage proteins in grain.  Directly binds to the promoters of starch synthase 1 (SS1), pullulanase (PUL), glutelin A1 (GLUA1), glutelins B4 and B5 (GLUB4 and GLUB5), alpha-globulin and 16 kDa prolamin, and activates their expression (By similarity).  Possesses transactivation activity in yeast (PubMed:27872632).
What are the official names of this protein?
NAC domain-containing protein 20, ONAC020, OsNAC20.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum.
Protein: ESYT1_HUMAN
Sequence: MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDLMDNKDKGSS
What is the function of this protein?
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).  Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels.  Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
What are the official names of this protein?
Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the extended synaptotagmin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200).
Protein: RL15_YERPE
Sequence: MRLNTLSPAEGAKHAPKRVGRGIGSGLGKTAGRGHKGQNSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAMITAEVRLSELALVEGDVIDLNTLKAANVVGIQMEFVKVILSGEVNRAVTLRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RS14Z_CHLAA
Sequence: MAKKSWIVRAQRPPKFSVRAYNRCKICGRSRAYIRKFGMCRICFREHALKGLIPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: TIG_SYNE7
Sequence: MSIKVTQEKLPASRVGLQIEVSGEQSRQVYERTLTRLSREVRFPGFRPGKVPRPVLIQRLGETALKANAIEDLVQQSLESAIAQESIPAIGNYQLSSDFETLVAAFQPGESFSFEASVDVQPTATLAQYTGLTVEVAEVPFDANRVDNVLAEQQKQMATLVPVEGRNAAIGDVAVIDFQGILVESGEEIPGGSGTDFQIEVEEDRFIPGFISGIVGMAIEETRTVDATFPETYAQEEVAGKAAQFTITLKELKTRDLPELDDAFAQEASQYETIEELKTALTERFQAEHESEVKASKRDAILTALADQLDVEIPESLLQREISAMINETASRLSGQGMDVRKLFTEEVLERLRENSKDEAEQRLRRTIALGELAKVTETQVDDEAVKARAAELLSNYPRPQEIDRDRLNTVVREELLEDKLLEWFEANNSVTFVAPKAAETEVDAASATVETTATETAEEAPEAPKAKKGKKKA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: GTR1_SCHPO
Sequence: MRKKVLLMGRSGSGKSSMRSIVFSNYVAKDTRRLGATIDIEHSHVRFLGNLVLNLWDCGGQEAFMENYLSAQRDHIFRNVQVLIYVFDVESREFERDLVTFRNCLEATVANSPQARVFCLIHKMDLVQEDLRDLVFEERKAILLETSKDLETTCLATSIWDETLFKAWSAIVYTLIPNTPTLESHLREFAKAAEAAEVILFERTTFLVISSYSSESNPATDAHRFEKISNIVKQFKLSCSKMQAQFTTFELRGGNFSAFIVPYTEDTYILVVIADPEIESAVTLMNIQSARRFIEASKSASDGIQLQP
What is the function of this protein?
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (By similarity).  Also required for TORC1 inactivation during nitrogen starvation (By similarity).
What are the official names of this protein?
GTP-binding protein gtr1.
What is the protein family that this protein belongs to?
Belongs to the GTR/RAG GTP-binding protein family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
Protein: Y3248_DICDI
Sequence: MGFKNVNNLEDDDDENYVGEDSNILNILDRIDTNISLAKNNIIQPLKTSKGDNKVEKPTDDGSNEEIKVPSSVYKKPDEPPLTTISSMYSTNTTSKPIPPNNNNNNNNNNSKITKLISNKKTETSTTKTETSNTNINPNSPPSVHGTKLIDLD
What are the official names of this protein?
Uncharacterized protein DDB_G0285189.
Protein: CF299_XENLA
Sequence: MEQSEAGSAADSIITQFNTYEDFLDSQITALDLHYLEDEELARQLVELGYRGSGEVLKRDEFEARKAAAEASRLSQRTQQKTLSSAGKDPKDNFLKALAMREEANRNGKMTSVIFIRDKNAHGQEVSGYIDFAHRLKTEDFEVYFSGKKKLLPRPTDLSFYNWESHVSTSNPSPNYQVIAETSSGLLFKNKRDRKILNVDPKASPGDNSTRTSIQTDIYIQAVIYDHITRRKS
What is the function of this protein?
May be involved in spermatogenesis.
What are the official names of this protein?
Cilia- and flagella-associated protein 299.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic.
Protein: RL14_SALHS
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CHPT1_MOUSE
Sequence: MAAGAGARPAPRWVKALGEPLSAAQLRRLEEHRYTAVGESLFEPPLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGTHPDWLFFCSFVGMFMFYCAHWQTYVSGVLRFGRVDVTEIQVALVIVFMLSTFGGATMWDYTIPILEIKLKIVPVLGVVGGLIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATNMFEKHPCLYTLMFGCVFAKVAQKLVIAHMTKSELYLQDTVFIGPGLLFLDQYFNNFIDEYVVLWIAMVISSFDMMIYFTSLCLQISRHLHLNIFKTSCQQAPEQVYKHID
What is the function of this protein?
Catalyzes phosphatidylcholine biosynthesis from CDP-choline.  It thereby plays a central role in the formation and maintenance of vesicular membranes.
What are the official names of this protein?
Cholinephosphotransferase 1, mCHPT1, Diabetic nephropathy-associated gene transcript 1, Diacylglycerol cholinephosphotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.