PharMolix/UniProtQA huggingface dataset:
Protein: ACBD5_XENLA
Sequence: MADTKPLHQTRFEAAVSVIQSLPKNGSFQPSNEMMLKFYSFYKQATLGPCNTARPGFWDPVGRYKWDAWNSLGDMSKEDAMIAYVDEMKKIIETMPVTDKVEELLQVIGPFYEIVEDKKHGRGSGVTSELGSVLTSTPNGKAVNGKAESSDSGAESDEEQAAAKEFKKEDEEDEEDETEHSEEEEKEVEQQPGHETSAESIVLNGLTKNSRVLITEEPTPLPTKCLSEPGDNVAIPEGEPDIQSAVINDSEADREEDCTEDMAAVQHLTSDSDSEIFCDSMEQFGQDEADHSLLLQDAMLNGDITENSAGGELKDGGEDGKQPGHGAQGKTWNGKSEHFSSRRERSLRMQPGGEGSRSGQIGSSGDGDGWGSDRGPIGNLNEQIAVVLMRLQEDMQNVLQRLHSLEVQTASQAQSLLRESNTQSVEKKPSGWPFGISPGTLALAVVWPFVVHWLMHVFLQKRRRKQT
What is the function of this protein?
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy.  Binds medium- and long-chain acyl-CoA esters (By similarity).
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG37 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: RIMM_PETMO
Sequence: MNSLSNLLDNKISVAKIVNSHGVHGEVKIVPFTNVKDVITNLEEVLLYNTSTRNFFFSKVLQVKPLNKFFVLNLRGIKDMDEAKKMIGYEVFIDKKDLPSLNSEEYYWYEILDSEVYYEDGEYVGKVEEIIQTGANDVISIKNLEDDKEVLIPMTDHYIIELKKEDKSIIVKKIEWYENGTNQAD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_KOSOT
Sequence: MKVIPLGERLLIKPIKEEKRTEGGIVLPDTAKEKPMKAEVIEIGKDVEDIDIKVGDKVIFSKYAGTEIKIDDEDYILIDQDDILAKVEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRG3_MOUSE
Sequence: MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTAPFFSSSTPGSRPPMPGAPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEHLKESQNGKNYSLKASSTKSESLMKSHVHLQNYSKADRHPVTALEKIMESSFSAPQSFPEVTSPDRGSQPIKHHSPGQRSGMLHRNTFRRAPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYVSNGLRTQQNASINMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSMGLEETCMQMPGISDVKSIKWCKNSYSADIVNASMPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDFELASMETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSVLTK
What is the function of this protein?
Direct ligand for the ERBB4 tyrosine kinase receptor.  Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor.  Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.
What are the official names of this protein?
Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3.
What is the protein family that this protein belongs to?
Belongs to the neuregulin family.
What are the subcellular locations of this protein?
[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. SUBCELLULAR LOCATION: [Neuregulin-3]: Secreted.
Protein: PLB1_CRYNH
Sequence: MSIATATFAFSLFATIAFAVPPETPRIELQAERGLGDKSYAPWQVDCPSNVTWIRNATTGLGSGERAYIEAREKLVQPVIEQMMAARGLETPPRTPNIGVALSGGGYRAMLTGLGGIMGMMNESTEASESETGGWLDGVSYWAGLSGGSWATGTFMSNGGQLPTNLLENLWNIDSNLVFPDDDKLSFYTELYTETNAKSDLGFPIQITDVWGLAIGSHVLPERYQLSNTPNLTFSSLPSVVSALGNASLPMPIIIAADRKRREAGELVIAENATVWEFTPYEFGSWAFGSQYKSPGAFTPIEYLGTSVDDGSPNGTCWKGFDQLSFVMGTSATLFNGAFLELNGTDSGLLTNLITAFLADLGEDQADISRIPNTFSNYNSGENPIYNLTYITLVDAGETNQNIPLEPLLVPTRDVDAIVAFDSSYDTDYIWPNGTALRTTYERAKVLAEHENTRVLMPEVPSMNGFVNGGYNSRPTFFGCNDTTTPLIIYVPSYPWSFAANTSTYQLSYENDEANEMLLNGMRSLTLNHSVPTWPTCFACALTDRSFMYTSENRSTTCQKCFDTWCWAGDDNTTEPATYEPVINSVPPWLVANNLSIGVADAPASNESTAGTASSGAAKADVSMGMVALAAGLGLML
What is the function of this protein?
Exhibits phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities.
What are the official names of this protein?
Phospholipase B, Lysophospholipase.
What is the protein family that this protein belongs to?
Belongs to the lysophospholipase family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Peripheral membrane protein. Note=Localizes to lipid rafts in the cell membrane prior to secretion.
Protein: A1KA1_LOXDE
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDDSANPEYTYHGVPCDCGRTCTKWEYFNEFLKGLRKATTPGDSKYHEKLVLVVFDLKTSSLYDNQASDAGKKLAKSLLQNYWNNGNNGGRAYIVLSIPNLAHYKLITGFKETLTSEGHPELMDKAGYDFSGNDEIGDVAKTYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVASRDSSNGYINKVYYWTVDKRATTRDALDAGVDGIMTNYPDVIADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LdSicTox-alphaIB1ai, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CARB_METLZ
Sequence: MPKNTSLKKVLLIGSGPIQIGQAAEFDYAGSQACKAVREEGIEVVLVNSNPATIQTDPETADKVYVEPLKADIIAEIIKKEKPDGILSGMGGQTGLNLTAELYELGALEGVQILGTPLEAIYHGEDRDLFKKLMLEIGEPIPKSFILTKIEQLDEAYEEVGLPAIIRPAYTLGGAGGGVANTKEELRTIVEHGLTKSRVHQVLIEESVKGWNEIEFEVMRDAADTCIIICGMENVDPMGVHTGESVVVAPILSLTSDEFGIMRRAAIKIIRALNVQGGCNIQFAFNNGDYRVIEVNPRVSRSSALASKATGYPIARVAAKVAIGLHLDEIMNTVTGCTPACFEPAVDYVVVKVSRWPFDKFKTADRTLTTSMKSTGEVMAIGRTVEEGFKKALRSLDTDIYRHTDLNEIRMILSRPTDERFPTLFDAFRLGMTVKEVYDLTQIEPFFLEKIQNVVDIELELRDHPTEELVKTSKKFGFSNAEIRELTGWNIYKIESLVGLPTYKMVDTCSAEFPAKTPYYYSTWEQECELTQSDRKKILILGSGAIRIGQGIEFDYCTVHAVKSLREEGIEVHILNNNPETVSTDFDTSDRLYFEPMQLEDVVNILRKGDYDGVMVQFGGQNSVNLAIPIQEEIKLFGLKTKVLGTSPDNMDVAEDRNRFSVLLDQNNIPSPANGSAYSEKEAYAIANKIGYPVLVRPSYVLGGRAMELVHDELELQTYIKEAVRVSNTHPVLIDRYLDNATELDVDAVSDGETVLIGGVMEHIEEAGVHSGDSACVIPTQTLTPEQIATVKDYTRKIALSLGVVGLINIQYAIHKGTVYVLEANPRASRTVPFVSKATGLPLAKIAAKLMLGKKLADLGYQEKEISHVAVKEVLLPFSRLPGVDPILGPEMKSTGEVIGIDYDFGRAFYKASQAADNTIPLKGNVFISVTNDQKTEILPIARKLYDLGFSLYGTEGTVKFLAQNDIPMNLVRKVQEGSPNILDMIRALDVHLLINTPGDKNARADHLQIMRASIDYSIPYITTIFGAEAAVQAIESMKTNTITVEPLSHYHS
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: DYL2_CAEEL
Sequence: MSEEKIEVKETDMEDPQRDMVISVVREAQRLYNIDKDVAAFVKEELDKKFGATWHVICGKCFGSRVSYEMGHFILLKCNKVNVMIYKCGY
What is the function of this protein?
Acts as one of several non-catalytic accessory components of a dynein complex.
What are the official names of this protein?
Probable dynein light chain 2, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y2020_AQUAE
Sequence: MPELQGKPLRFYLLRLTTTLPLTTYLNLWPRSLLPFSFTLWDPTTTGTEKRGLPRSYSQSERLCSSSLQKSSSELKSKIIMKKFFLFLVLPIFLFASPLKAVFDCAVGDLDWISLRLSLIKKTAEQLMEEGKSYRFVITIHSHCIKVVDADLKKFPESERRKIELIQSQLKTLKEMYSVDVKACQIAMNRGKIKKVPPFVETVPNSWITLIELQNKGFAFVPF
What are the official names of this protein?
Uncharacterized protein aq_2020.
Protein: REP7_FBNY1
Sequence: MPSIRATHWCFTLNFSGSIPEINWTADVQYSIWQHERVGHDHLQGYIQMNKHVTLKKMKELLPGAHLEMAKAPKKAIEYCQKKESAIAGPWEYGTWISSGSHKRKLMERFEDGPEEMKLEDPGLYRRCLSRVQMKKIRESCTWNFDLRPWQDELLKTIEQEPDDRTIIWVYGPHGGEGKSAFAKYLTLKEGWWYTAGGKATDMLYSYSLDPTCHVCIDIPRCTREEYINYSVIEQIKNRVIINTKYEPCTIRDDGHNVHVIVFCNFLPDVTRISEDRIKIINC
What is the function of this protein?
Initiates and terminates the replication only of its own subviral DNA molecule.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Para-Rep C7, Rep7, ATP-dependent helicase C7, Replication-associated protein of non-essential DNA C7.
What is the protein family that this protein belongs to?
Belongs to the nanoviridea/circoviridae replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CHDC_BACC1
Sequence: MSEATTTLDGWYCLHDLRSIDWAAWKTLSSDERGQAVSEFLNVVEKWNDVAATKKGSHAMYTVVGQKADIMLMILRPTMEELNEIETELNKTTLAEYMVPAYSYVSVVELSNYLPADEDPYQNPQILARLYPELPKANHICFYPMDKRRQGDDNWYMLPMEERKKMMYSHSKIGRQYAGKVRQVISGSVGFDDFEWGVTLFADDVLQFKKLIYEMRFDEVSARYGEFGTFFVGNILPDEKVEKFLHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: UVRB_CHLTA
Sequence: MGGGVLKQQFVLHAPFLPCGDQPEAIRRLSQGITDGVPAQVLLGTTGSGKTFTMANVIANVNVPTLVLAHNKTLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYGIGSPDNYSSMALTLEVGKEYPRSQLSSQLVRMHYQASSTPQRSAFRERGSVIDIFLAYESDLAVRLEFMNDTLISIEYVDPLTMIPSHTTSSITLYPGSHYVTPEAVREQAIRTIREELEQRMLFFEGRPVEQERLFQRTTHDIEMIKEIGFCKGIENYSRHFTGAAPGEPPTCLLDYFPDDFLLIIDESHQTLPQLRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFHRVIYVSATPGDLEIQESRGHIIEQIIRPTGIPDPLPEIRPAKGQIDDLLEEIRQRLRKDQEKILVISVTKKLAEDIAAFLAELGIAATYLHSGIETAERTQILTDLRLGNIDVLIGVNLLREGIDLPEVSLVAILDADKEGFLRSSASLIQFCGRAARNIHGKVICYADRITPSMDHMLKETERRRKIQLDYNQQHKITPQPIIKPILANPITKEAGQEETRLKMQSSKELEASIKTYEEAMYQAAQEFQFDEAVKYRDLMNAAKKQLLFQKGEEENGD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQAE_ECO57
Sequence: MGFWRIVITIILPPLGVLLGKGFGWAFIINILLTLLGYIPGLIHAFWVQTRD
What are the official names of this protein?
UPF0057 membrane protein YqaE.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SCO2B_MOUSE
Sequence: MAALRLLAWALPRGVSALRPRPALPHRLIRRYVSDRSGSVHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRACGTGVPAFYTPTGYGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVDRVIKGPKFEKRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSPNLKPMQQIKLDA
What is the function of this protein?
Key enzyme for ketone body catabolism.  Transfers the CoA moiety from succinate to acetoacetate.  Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).  Probably play and important roles in the energy metabolism of spermatozoa.
What are the official names of this protein?
Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial, 3-oxoacid CoA-transferase 2B, Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2, SCOT-t2.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RHAM_BACSU
Sequence: MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIFLDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFYLD
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORN_MYCUA
Sequence: MREELVWIDCEMTGLDLGPDKLIEIAALVTDADLNILGDGVDVVIHADDAALSSMVDVVADMHSRSGLTEEVRASTVDMATAEAMVLDYIGEHVKQPKTAPLAGNSIATDRSFIARDMPALDAFLHYRMIDVSSIKELCRRWYPRIYFGQPPKGLAHRALADIHESIRELQYYRRTAFVPQPGPTTSEITAVVADLQGVDDAPEATDSAQERPSG
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL10_MOUSE
Sequence: MAPRPLGPLVLALGGAAAVLGSVLFILWKAYFGRGRERRWDRGEAWWGADTARLPQWDEWEPEDEEDEPALEELEQREVLVLGLDGSGKSTFLRMLAGKPPVEGHVPTWGFNSVRLPTKNFEVDLLEIGGSQNLRFYWKEFVNEVDVLVFMVDSTDRLRLPWARQELQKLLDRDPDLPVVIVANKQDLSGAMNMVELQQELGLLASYNQREVFLLAASIAPAGSGFGEPGTVHIWKLLLQLLS
What are the official names of this protein?
ADP-ribosylation factor-like protein 10, ADP-ribosylation factor-like membrane-associated protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
Protein: VL2_BPV2
Sequence: MSARKRVKRANVYDLYRTCKQAGTCPPDVIPKVEGDTIADKILKLGGLAIYLGGLGIGTWSTGRVAAGGSPRYVPLRTSGSTTSLASVGSRAGAATGTRSSITGIPLDTLETIGALRPGAYEDTVLPEAPAIVTPDAVPADTGIDGLSIGTDSSTETLITLLEPEGPEDVAVLELQPLDHANWQVSNAVHQGSAYHAPLQLQSSIAETSGLENIFVGGAGLGDTGGENIELTFFGSPRTSTPRNLPQTARGILNWFSKRYYTQIPTEDPDVFSSQTFSNPLYDPEPAVLKGPSGRVGLSQVYRPDFIETRGGGQVGPQLHVRYSLSTITEDVEAIPIAVDEDTQGLAFIPLHEEPGDFEEIELDDLGEEHALLPKSYTAPIGSGVRRALIPGQGFSATRPTGVVTYGSPDMYPASPVGPDSTSPSLVIDDNTTTPIIIIDGHTVDLYSNNYSLHPSLLRKRKKRKHA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: SYA_GRAFK
Sequence: MKSQDIRKQFLEFFKSKSHTIVPSAPMVLKDDPTLMFTNAGMVQFKEFFLGNSVAKSNRVTDTQKCLRVSGKHNDLEEVGHDTYHHTMFEMLGNWSFGDYFKEEAISWAWELLTEVYKISPENLYVSVFEGSDDRDDLGLDTEALELWKKIVPEERIIYGNKKDNFWEMGDQGPCGPCSEIHIDIRSEEEKAKTPGRDLVNMDHPQVVEIWNLVFMQYNRKANGDLEELPAKHIDTGMGFERLCMVLQNTQSNYDTDVFTPLVGEIEEITGVTYGKSEENNIAMRVIADHVRAVAFSIADGQLPSNTGAGYVIRRILRRAIRYGFTFLNTKEPFIYKLVPVLSGQMGATFQELKSQQNLIENVIREEEASFLRTLDQGLILLENLMKESKDKTISGEKAFELYDTFGFPIDLTALILKENGYDLDEKGFEAELKKQKDRSREATAVSAGDWIELNPVDEESFVGYDKLEADAKIARYRKVESKKKGEMFQVVLNKTPFYPEGGGQVGDKGILMSSDGEVVDVVDTKKENNQIIHFTKNLPKNTEAEFKAIVNKTERYNTASNHTATHLLHQALRSILGTHVEQKGSMVQSGYLRFDFSHFSKVTGEELEKVENFVNARIREQLSLDEQRNISYQEAIDQGAIALFGEKYGDSVRAIRFGDSMELCGGIHVKNTSDIWHFKISGESAVASGIRRIEAITGEAAMKYFEEQTNILEEIKSGLKNSNDPVKAINNLQEENINLKRQIESLLKDKAKNLKSKLKHEVKSINGVNFLSKKVDLDAAGIKDLAFQLGEEIDDLFILFGAEQHGKALLSCYISKELVKGKDLNAGQIVRELGKYIQGGGGGQPFFATAGGKNPDGLNEALQKAESFIK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHPD_ECO8A
Sequence: MTKHTLEQLAADLRRAAEQGEAIAPLRDLLGIDNAEAAYAIQHINVQYDVVQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQARIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRAGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase, 2-hydroxypentadienoic acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: TERS_BPP22
Sequence: MAAPKGNRFWEARSSHGRNPKFESPEALWAACCEYFEWVEANPLWEMKAFSYQGEVIQEPIAKMRAMTITGLTLFIDVTLETWRTYRLREDLSEVVTRAEQVIYDQKFSGAAADLLNANIIARDLGLKEQSQVEDVTPDKGDRDKRRSRIKELFNRGTGRDS
What is the function of this protein?
The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit.  The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities.  Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine.  The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging).  Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
What are the official names of this protein?
Terminase, small subunit, DNA-packaging protein gp3.
What is the protein family that this protein belongs to?
Belongs to the P22likvirus small terminase family.
Protein: RL31_RHIL3
Sequence: MKAGIHPEYHMIKVVMTDGTEYETRSTWGSEGAVMNLEIDSKSHPAWTGGNQQLMDRGGRVSKFNKRFGGLGL
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TRPD_PSEP1
Sequence: MDIKNALSRIVGQLDLTTEEMREVMRQIMTGQCSEAQIGAFLMGMRMKSESIDEIVGAVSVMRELAEKVELQSLDGVVDIVGTGGDGANIFNVSTASSFVLAAAGCPVAKHGNRAVSGKSGSADLLEAAGIYLNLTPTQVARCIDSLGIGFMFAQSHHSAMKHAAGPRRELGLRTLFNMLGPLTNPAGVKHQVVGVFAQTLCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAELKNGEITEYWVEPEDLGMKSQSLHGLAVESPQASLELIRDALGRRKTENGQKAAEMIVLNAGAALYAADHAMSLKAGVELAHDVLHTGLAWEKLQELGAFTAVFKVENEA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: BCCIP_HUMAN
Sequence: MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV
What is the function of this protein?
During interphase, required for microtubule organizing and anchoring activities.  During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342).  Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342).  May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A.  May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.  May not be involved in non-homologous end joining (NHEJ).
What are the official names of this protein?
BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1.
What is the protein family that this protein belongs to?
Belongs to the BCP1 family.