PharMolix/UniProtQA huggingface dataset:
Protein: COX3_HELAN
Sequence: MIESQRHSYHLVDPSPWPISGSLGALATTVGGVMYMHSFQGGATLLSLGLIFILYTMFVWWRDVLRESTLEGHHTKVVQLGPRYGFILFIVSEVMFLFALFRASSHSSLAPTVEIGGIWPPKGIAVLDPREIPFLNTPIPLSSGAAVTWAHHAILAGKEKRAVYALVATVSLALVFTAFQGMEYYQAPSTISDSIYGSTFFLATGFHGFHVIIGTLFSIVCGIRQYLGHLTKEHHVGFEAAAWYWHFVDVVRLFPFVSIYWWGGI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GATB_CLOB1
Sequence: MDFEAVIGLEVHAELSTNTKIYCGCTTEFGGQPNTHVCPICLGLPGSLPQLNKRVVEYGIKAGLALNCSINKVCRMDRKNYFYPDCPKNYQITQDEVPICRDGYIEIELENGEKKKIGIERIHMEEDAGKLLHTNAGTLVDYNRAGVPLIEIVSRPDIRTPEEATKYLEKLKSILSSIEVSDCKMEQGSLRCDGNISVMPKGSEKFGVRSEIKNMNSFKALEKALSYEYDRHVEAVTKGEILEQETRRWDEANSVTVLMRSKEKANDYRYFPEGDLVTLNISDEWIEEVRKTIPELPHEKAERFVNEFGIPKYDAMVLTLTMDMAKFFEETALKSEDAKAASNWLMGDISRLMNEKAIEVKDLKFNPEQLAQLIKLINAGTISNNIGKKVLDDMFKSGKNPKDIVEEKGLVQNNDEGAILEVVKNIIENNPQSIEDFKNGKKRALGFLVGLVMKETKGKANPQIVNKLVSEEANKM
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: CCSA_JASNU
Sequence: MIFSTLEHILTHISFSIVSILVTIHLITFLVDEIRKLYDSFEKGMILAFFCITGLLVIRWIYSGHFPLSNLYESLMFLSWSLSLIHRVPYFKKNQKFLSTIIGPSAIFTQAFATSGLLTEIHESTILVPALQSEWLIMHVSMMILGYAALLCGSLLSVALLVIAVRKNKKSFFTSNPLFKLNGSFFFGEIEYMDERINVLQNTPNTSFFSTFFSTKNYYRSQFIQQLDYWSYRVISLGFLFLTIGILSGAVWANEAWGSYWSWDPKETWAFITWIVFAIFLHIRTNVKWKGTNSAIVASIGFLIIWICYFGVNLLGIGLHSYGSFTLTSN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YIIG_ECOLI
Sequence: MKRNLLSSAIIVAIMSLGLTGCDDKKAETETLPPANSQPAAPAPEAKPTEAPVAKAEAKPETPAQPVVDEQAVFDEKMDVYIKCYNKLQIPVQRSLARYADWLKDFKQGPTGEERTVYGIYGISESNLAECEKGVKSAVALTPALQPIDGVAVSYIDAAVALGNTINEMDKYYTQENYKDDAFAKGKTLHQTFLKNLEAFEPVAESYHAAIQEINDKRQLAELKNIEEREGKTFHYYSLAVMISAKQINNLISQDKFDAEAAMKKVSELETLVAQAKEADKGGMNFSFINSAGQYQLEAKKYVRRIRDKVPYSDWDKEQLQDANSSWMVEDSFPRALREYNEMVDDYNSLR
What are the official names of this protein?
Uncharacterized protein YiiG.
Protein: PYRD_DELAS
Sequence: MSLIPYALTRPFLFGMDPESAHDLTMNLMAKGQNTLLQQAWAQPMVSDPVELAGLKFPNRVGMAAGLDKNARCIDALAAMGFGFVEVGTVTPRPQPGNPKPRMFRIPERNALINRLGFNNEGLDAFLSNVKRSQARAQGKPMLLGLNIGKNATTPIEDATSDYLKALDGVYPHADYVTVNISSPNTKNLRALQSDEALDALLGAIAERREQLATQHGKRVPVFVKIAPDLDEEQVGVIAATLQRHGMDGVIATNTTISREAVKGLPYAQETGGLSGAPVLEASNQVIRQLRSALGSRYPIIGVGGILSGEDAVSKIRAGADVVQIYSGLIYRGPALVPETARAIAQLR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRC_NEIMA
Sequence: MQTLTIIRPDDMHLHLRDGDALKAVAPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDQATPALVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAHKFFLGTDSAPHAKSAKENACGCAGMFSAMTAIELYAEVFEKAGALDKLEAFASKNGARFYGIPENTDTITLVKQSQTVPASIPYGDGELVPMRAGGEIGWTVQY
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: RTC4_YEAS2
Sequence: MVGPGLGINRVRRKGVYSTKKGSGDNLLLMKRQGKHDIHDRESDDLSGHDAFSPSKKRGKIDSITEDEIEVKKLSTVATFDKLSRSFPNSEVQAAKNAALRGKEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDGKKLLLEAELSAVEDNQIFSSSFPEDKKLSLQSCLSSKEQIIKKLQVREEYMSKFKLPPMLFSDELLTEVEPFMPIVMDILEGKISSAYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNLSNKSCSSKTPNKHPKQQLNEKEYYYDPELRMLAYDLLEDTVEYGIIVADSDPIEQWEAAIEEDRLRELKLDVHNYSSRRWRLDTHD
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 4.
What is the protein family that this protein belongs to?
Belongs to the RTC4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRPF_STAAS
Sequence: MKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVMVNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKYKGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGYDLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RPPH_ACIB5
Sequence: MIDSEGFRPNVGIILANDDGQVLWAKRIGHNAWQFPQGGIQFGETPEQALFRELREEIGLLPEHVQIIAQTKGWLRYRLPHRYIRSDSDPVCIGQKQKWFLLKLTAPAKNIQLNLADPPEFDEWQWVSYWYPLGQVVNFKRDVYRKAMVELCTQLPVQQLP
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: SPRTL_BACAC
Sequence: MDEQEIQRLVEEVSLQYFGMPFLHKAMFNSRLRTTGGRYLLNTHNIELNYRYYEMYGKEELVGIVKHELCHYHLHITGRGYKHRDKDFRELLKAVDAPRFCKRMVNAEKEKRVYVYECMECLLQYVRRRQINTKRYVCGKCKGKLNLIKKTS
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_HYDCU
Sequence: MVVLDSVSTLRESIQKWRKAGLTIGFVPTMGNLHAGHLSLVKQARQKSDKVIVSIFVNPLQFGPDEDYDRYPRTFEADKALLQQHNADAVFCPSVDEMYPNGQAQTRVIAPEKMTSILEGAKRPGHFDGVTTVVAKLFNMVQPDIAILGQKDFQQFAVLQQMVEDLALSVELIRAPIVRDETGLALSSRNQYLTEIQRSVAPKLFVALQSIEMAIRSGNKNYSSLCQIATQQVLSDGFDAVDYIQVLNASSLEEPQQGDQALVIVAAAKLGQTRLLDNVLVSL
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFB2_KLULA
Sequence: MSLNLFKTTVNDYLEGLPEQVQSRLYESPATCLAIYRLLSPMAKFFIMSMLFQDHDVSLRDLDKWVKPDAKYQLQYSIKSMKSLNLIIEGESKQPLLIRLNPIFKKSFKNVLTGGEINNSFGDVADDDTNPVSTATLDQYSAEKWETILHYMVGTPNTNTPGGKVLDLLQHSGLMEEAEYGELKITNQGFQFLLQDVNAQMWTLLLQYLKMAESLQMDPVDVLNFIFMLGALQLGKAYKCDQLSNTQRTMLQDMRDYGLIYQNQSDYAKFYPTRLATLLTSDTKAFRSASVALDSVLNKANETTAVEGDSGQDETTERTQDGALIIETNFKLYSYSNSPLQIAILSLFVHLKSRFANMVTGQLTRESVRNALLNGITAEQIIAYLETHAHPRMRRLAEENLSKKLELDPTVKETLQVLPPTVVDQIRLWQLELDRIISYDGYLYTDFESYQEYQTVADYAKDIGVLLWQNEKKKMFFVSTEGNSQVLDFHRRNFDK
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB2, TFIIH subunit TFB2, RNA polymerase II transcription factor B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the TFB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TBCA_ARATH
Sequence: MATIRNLKIKTSTCKRIVKELHSYEKEVEREAAKTADMKDKGADPYDLKQQENVLGESRMMIPDCHKRLESALADLKSTLAELEETDEKEGPEIEDAKKTVADVEKQFPTEDA
What is the function of this protein?
Tubulin-folding protein involved in the control of the alpha-/beta-tubulin monomer balance.  Functions as a reservoir of bound and non-toxic beta-tubulin.  Required in the developing embryo.
What are the official names of this protein?
Tubulin-folding cofactor A, AtTFCA, CFA, Protein KIESEL, TCP1-chaperonin cofactor A, Tubulin-specific chaperone A.
What is the protein family that this protein belongs to?
Belongs to the TBCA family.
Protein: DEF11_ARATH
Sequence: MGKTISFSAIILVFLLVSTGLMKQGDAQAQKCEWECKLLPNFPCWLKGAGEGLCDNLCKYEGAISGVCVSDPHRCLCRNRKPGCS
What are the official names of this protein?
Defensin-like protein 11.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYNS_ASPTN
Sequence: MSLATLDISQHPNLPASAQTLFKAKADKKLSFEQIAQHIGRNEVAAAALFYGQAKASPEDIVKLSELLDIPTPLLEEQLSGFPDRGRSVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDQDGNNWAVITLRGKW
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: HBB1_GOBGI
Sequence: VEWTDKERAIITDIFSHMDYDDIGPKALSRCLIVYPWTQRHFSGFGNLYNAEAIIGNANVAAHGIKVLHGLDRGVKNMDNIAATYAELSTLHSEKLHVDPDNFKLLSDCITIVVAAKLGHAFTAETQGALQKFLAVVVSALGKQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LPXA_HELPY
Sequence: MSKIAKTAIISPKAEINKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFVGKNTEIFPFAVLGTQPQDLKYKGEYSELIIGEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVAHDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIAKGCMIAGKSALGKDVPPYCTVEGNRAFIRGLNRHRMRQLLESKDIDFIYALYKRLFRPIPSLRESAKLELEEHANNPFVKEICSFILESSRGVAYKSSEYSSEEKQEE
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUK1_CLOAB
Sequence: MYRLLIINPGSTSTKIGIYDDEKEIFEKTLRHSAEEIEKYNTIFDQFQFRKNVILDALKEANIEVSSLNAVVGRGGLLKPIVSGTYAVNQKMLEDLKVGVQGQHASNLGGIIANEIAKEINVPAYIVDPVVVDELDEVSRISGMADIPRKSIFHALNQKAVARRYAKEVGKKYEDLNLIVVHMGGGTSVGTHKDGRVIEVNNTLDGEGPFSPERSGGVPIGDLVRLCFSNKYTYEEVMKKINGKGGVVSYLNTIDFKAVVDKALEGDKKCALIYEAFTFQVAKEIGKCSTVLKGNVDAIILTGGIAYNEHVCNAIEDRVKFIAPVVRYGGEDELLALAEGGLRVLRGEEKAKEYK
What is the function of this protein?
Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.
What are the official names of this protein?
Butyrate kinase 1, BK 1, BKI.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFC4_SCHPO
Sequence: MSNAVSSSVFGEKNNSVAYELPWVEKYRPIVLDDIVGNEETIDRLKVIAKEGNMPHLVISGMPGIGKTTSILCLAHALLGPAYKEGVLELNASDERGIDVVRNRIKAFAQKKVILPPGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNQSNKIIEPIQSRCAILRYSRLTDQQVLQRLLNICKAEKVNYTDDGLAALIMTAEGDMRQAVNNLQSTVAGFGLVNGENVFRVADQPSPVAIHAMLTACQSGNIDVALEKLQGIWDLGFSAVDIVTNMFRVVKTMDSIPEFSRLEMLKEIGQTHMIILEGVQTLLQLSGLVCRLAKSQMKPESFII
What is the function of this protein?
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.
What are the official names of this protein?
Replication factor C subunit 4, Replication factor C4.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FYV8_ASHGO
Sequence: MPDKVNRRKSQRWVSVSKGNYDGADWDSDYSGEELESSPTRQHETICKLPELPKLNLGGSTEERGRPGSGDGLAPRGAAEEEAASSGRGAATPAHEVQTPRSGAAAQKFSLTSSSRSVSSMNKELDTLMDEISKEMTAGGSEPPLVETRQSPVDFNRVGVPALKPEGHLADDSSDSDGEDAAGGSSLSQSFEHLNMSLKTDTASGQAMPLSSPRGSSALPAGRDSLALKKGASPDRASEGSLSSRSEDLLAVDRTAGENTRLKTTNSSDDDTDSLPELITSDAKFRADGASGPARVVSSGVETVIHRAIAPEVAPRLRITSKTDLSYRYDTSSEDDSEAYSGIEDDYLSYQPSPNISDAATFHGHRSRTGSPARAPHPLVEQEEHIELPVISDDDSTSKSSVRDNYYSEESDNTTSQALVTQDNSSHDTIHDTIRERSFDKSTSGSVTHSIPVIKDDNEDWQNQLRQQSVHLGAWNPDTEGKRGAFLTQASPMSTNKGMCGSQDEETTGDDQQLAEPCNDDSDSVWEGFPSVGEYEDLQSVADIKTIYDNQTLYNVPGIITSSTSVPPLPSSMSELTSRQDTSILSESTSGSGLDSDSLMRVVEGQRHAPKPSMFKENFGQTPEVQVEHLVNSPVPSLDICALIEGPQSHSFKRDKLNSHIEDLNAYSSGAQTWIKYALKSTQSSSNITFDEYVISKHVQDAYAQAEEVSKKHSVTNAVNQNVSQLRKKVFSHSMKEGAKGLLSSIGKKKL
What is the function of this protein?
Involved in the resistance to unfolded protein response (UPR)-inducing agents.
What are the official names of this protein?
Protein FYV8.
What is the protein family that this protein belongs to?
Belongs to the FYV8 family.
Protein: METK_CLAMS
Sequence: MTDLRLFTSESVTEGHPDKICDQISDSILDALLTQDPSSRAAVETLVTTGLVHVAGEVTTSGYVDIPQIVRDRIRDIGYDSSEVGFDGSNCGVTVSIGAQSPDIAQGVDRSYESRSGSASTDAHDLQGAGDQGLMFGYASRDTPVFMPLPIYLAHRLAERLAAVRHSGELSYLRPDGKTQVTIGYEGLVPRTVDTVVLSTQHGPQVSQEDLRREVEEHVIRPVLAAAAEIGIELDSRDATLLINPTGKFEIGGPKGDAGLTGRKIIVDTYGGFSRHGGGAFSGKDPSKVDRSAAYAMRWVAKNAVAAGLADRLEVQVAYAIGKAAPVGLYVEAFGTAHVPEDRIVRAIRETFDLRPAAIVERLDLLRPIYAETAAYGHFGRELPDFTWEALDRVADLQSAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_RICCK
Sequence: MNPQLHNIILPIYMDYQATTPLDPRVMEAMLPYFTTKFGNPHSRSHSFGWEAENAVEEARSRVAKLIGADAKEIIFTSGATESNNLAIKGIAKFYGNKKNHIITVVSEHKCVLDACRHLEQEGIKITYLPINPNGIIDLEILKESITNQTMLVSVMAVNNEIGVIQPLKEIGKICRERGVFLHSDIAQGFGKIPINVNEFNIDLASISGHKIYGPKGVGALYVRKKPRIRVTPLINGGGQERGMRSGTLPTPLIVGLGMAAEIAYNEMEKDNKHVSYLFDRFLNNIKQKISEVYLNGDKDQRYKGNLNLSFAGVEGESIILAIKDLAVSSGSACTSASLEPSYVLRSMGIGEELAHTSIRFGIGKFTTEQEIDYAVDLICSKIDKLRELSPLWEMMQQGIDLKKIKWASH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRSA_ECODH
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEDDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: RL1_SHIDS
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: LHA6_RHOAC
Sequence: MYKLWLLFDPRRALVALSAFLFVLALIIHFIALSTDRFNWLEGKPAVKAA
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-880 alpha chain, Antenna pigment protein alpha chain.
What is the protein family that this protein belongs to?
Belongs to the antenna complex alpha subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: TGT_LARHH
Sequence: MLEFTLHKTSGHARRGTLRLNHGTIETPVFMPVGTYGAVKAMTPDRLDETGAQIILGNTFHLWLRPGLDVIGTFGGLHDFTGWHKPILTDSGGFQVFSLGDLRKITEEGVHFQSPINGDKLFLSPEKSMEIQTVLNSDIVMQLDECTPGQVDHATAKASMQMSLRWAERSRRAFDDYRNPNALFGIVQGNLYLDLREESLKGLTDIGFDGIAVGGLSVGEPKPEMYRVLREVGPMLPADKPHYLMGVGTPEDLVEGVANGIDMFDCVMPTRNARNGWLFTRWGDVKIKNARYKDDTRPLDEQCSCYTCRHFSRGYLHHLHRTGEITGAMLNTVHNLHYYQELMADMRAAIEADSFAGFQQEFHAQRARGA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: INT7_MOUSE
Sequence: MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRVFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDALLASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAVQDLKLLASKTPHTWSKENIQALCECALHTPYDSLKLGMLSVLSTLSGTIAIKHYFSVVPGNVGSSPRSSDLVKLAQECCYHSNRGIAAHGVRVLTNITVSCQEKDLLSLEQDAVFGLESLLVLCSQDDSPGAQSTVKSALSCMVKLAKGRPHLSRSVVDTLLTQLHSSQDAARILMCHCLAAIAMQLPVLGDGMLGDLVELYKVIGRSATDKQQELLVSLATVIFVASQKALSAEVKAVIKQQLESVSSGWTVYRIARQASRMGNHDMARELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEDSFSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYRDLYQASFDADSATLRNVELQQQSCLLIAHAIEALVLDPESASFQEYGSTGAAHADSEYERRMMSVYSRVLEEVESLNRKYAPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRSPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRRVQSVCLNVSSTLQSKSGQDYKIPIDSMTNEMEQRVEPHNDYFSTQFLLNFAVLGTHSITVESSVRDANGIVWKTGPRTTMFVKSLEDPYSQQIRLQQQAQQPLQPQPLPQPQPRSAYTRF
What is the function of this protein?
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.  Plays a role in DNA damage response (DDR) signaling during the S phase.  May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.
What are the official names of this protein?
Integrator complex subunit 7, Int7.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 7 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Protein: CYSC_SHIFL
Sequence: MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLSVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.