PharMolix/UniProtQA huggingface dataset:
Protein: LON_AZOC5
Sequence: MVNTPVPGLGSCASRGLIAAPASIIRSRPGCDHAGECIVVCVGVFRKDWVMTSPKQRPPLVPGVAQTFPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLATQENASDDDPATDAIYRVGTLATVLQLLKLPDGTVKVLVEGVTRAQVVQYTDRADLYEAEAISLPDEVGDVVEAEALARSVVNEFENYVKLNKKVSPEVVGVVGQIEDHAKLADTIASHLAVKIPEKQAVLETVKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMKAIQKELGDEDGRDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNYLDWLLSIPWGIKSKVKKDLPFAQSVLDSDHYGLDKVKERIVEYLAVQSRANKLAGPILCLVGPPGVGKTSLGRSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAKKSNPLFLLDEIDKMGADFRGDPSAALLEVLDPEQNPTFNDHYLEVDYDLSNVMFVTTANTLNIPPALLDRMEVIRIAGYTEDEKAEISRKHLIPNALQKHGLSAKEWSIDDAALLQVIRRYTREAGVRNLEREISTLARKAVKELVISKKKSVKVTAKNLETFLGVPRFRYGEIEREDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISAAASYVRSRSVDFGIEPPLFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPVRRDVAMTGEITLRGRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNALEIIPVSRMDEVLHHALLRHPEPISWTEQPVSGAVVPDEDAAGVVAH
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TACD2_HUMAN
Sequence: MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL
What is the function of this protein?
May function as a growth factor receptor.
What are the official names of this protein?
Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1.
What is the protein family that this protein belongs to?
Belongs to the EPCAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SODC_SCHMA
Sequence: MKAVCVMTGTAGVKGVVKFTQETDNGPVHVHAEFSGLKAGKHGFHVHEFGDTTNGCTSAGAHFNPTKQEHGAPEDSIRHVGDLGNVVAGADGNAVYNATDKLISLNGSHSIIGRTMVIHENEDDLGRGGHELSKVTGNAGGRLACGVIGLAAE
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y264_METJA
Sequence: MHQVKSFLLLAIDGEKMVVVNVGSCIGCRRCERSCPINGITFNEFPIKCMHCDRNPCLYACPENAIERINNKVVVIKDKCVGCGLCALACPFGAIRIDGVAIKCNGCYKRDVEICKEVCPTGAINNLEEILNNKIQNTVNKFNKLYYLYANAK
What are the official names of this protein?
Uncharacterized protein MJ0264.
Protein: ENPP2_HUMAN
Sequence: MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYESEI
What is the function of this protein?
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767).  Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380).  Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380).  Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993).  Involved in several motility-related processes such as angiogenesis and neurite outgrowth.  Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573).  Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949).  May have a role in induction of parturition (PubMed:12176993).  Possible involvement in cell proliferation and adipose tissue development (Probable).  Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573).  Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252).  Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252).
What are the official names of this protein?
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y4RO_SINFN
Sequence: MPNVQSLAIIVTDPRLIISTWKDRCPAPLSSVGGMPILARLVSQLAQAGVQKTIVFALDGIGDVKRILNNRMKRMELVIRIMPTPGSGRLIDLATITEIAEFHGQVLVFTENAVIDPSLIQRLLRSSDRNITVVSRSERRRCLRLLGDIGGRLTAMLPGDSPIRESASADVSPVGIYKFDPALLRAIARIRPHRFNDDLEFFETALGLQRHQIYLMYADPQHVRRVNDATDLEAANFASSSSGDQFSILERLQAGNWRYPASEHILLCNHHFPPASVVDRLRERLQDLLYLQPSDQLDIIAKLSEMTDLPARNLAVGNGVGELIKALYGYLDPRIVIPTPTSAQYIDAVEPNKVSRFELPPENFDLDVEAFANFAKRRQASVAVLVNPNNPTGRLVPVQEIEWLASQLAIEKCRLVVDETFIEFSVAGKGNSVEKLLSVFPKMVILKSLGAIMGLGGAQIGYLASKDEQLTHGVRRRLPLGNINGIAEYLLWILPEFREEWEASFRRTRADVVSFSRMLDTIPELEVHPSQANYLFCRTPEAWPSAKHVATMLAKRYGVLVQNCENQCMKYGDRYLRLTVLPYEENRYLVSALRRINEELVEWSTQSKRAGTAYHLGC
What are the official names of this protein?
Uncharacterized protein y4rO.
What is the protein family that this protein belongs to?
To Rhizobium NGR234A y4qD.
Protein: TRPC3_HUMAN
Sequence: MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
What is the function of this protein?
Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376).  May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775).
What are the official names of this protein?
Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AA2BR_MOUSE
Sequence: MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRMELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGQAGAQSTLSLGL
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A2b.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VKT1_ANTAF
Sequence: APVNEDCLLPKKVGPCRAAVPRFYYNSDSGKCEGFTYGGCHANANNFKTKDECKNACH
What is the function of this protein?
Serine protease inhibitor that is strongly active against trypsin (1900 IU/mg) and moderately active against plasmin.  Also shows weak inhibition against chymotrypsin (70%), elastase (38%) and the metalloprotease thermolysin (14%).
What are the official names of this protein?
PI-actitoxin-Axm2a, PI-AITX-Axm2a, Kunitz-type protease inhibitor AXPI-I, AXAPI.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RL14_THETH
Sequence: MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRGAVKEGDVVKAVVVRTKKEVKRPDGSAIRFDDNAAVIINNQLEPRGTRVFGPVARELREKGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NDHH_SYNY3
Sequence: MTKIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAESRTNIMYVPYVSRWDYAAGMFNEAITVNAPEKLADIEVPKRAQYIRVIMLELNRIANHLLWLGPFMADVGAQTPFFYIFREREMIYDLWEAASGMRLINNNYFRVGGVAVDLPYGWNDKCEDFCDYFLPKVDEYEKLITNNPIFRRRVEGVGTVTREEAINWGLSGPMLRGSGVKWDLRKVDHYECYDELDWEVQYETAGDCFARYLVRIREMRESVKIIRQALKAMPGGPYENLEAKRLQEGKKSEWNDFQYQYIAKKVAPTFKIPAGEHYVRLESGKGELGIFIQGNDDVFPWRWKIRSADFNNLQILPHILKGVKVADIMAILGSIDIIMGSVDR
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase subunit H, NDH-1 subunit H, NDH-H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RLP7_DEBHA
Sequence: MAVLNSNPEILLRKRKNNDRKRLEKQEQARQRQLEQKKKNDQRSKKFVRAETLVSNYKSNELENKRIKHITKFEKQSQADKISQAKEDDESAKLLFIIRIPDHTKGLKVPSKARKVLHLLRLNRPNTGVFVKLTPATVPLLKLISPYIVAGKPSLNSIRKLFQKRACISVIDEETKEPRITKLDNNGVVEDKFGDDLGCICIEDLIHELATLGEHFKTVSNWILPFKLNAPVSGWGPQAKLAKLQYSNEHQRKISLAGDAKLNEIDIDQFIDEQN
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein RLP7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y4652_BACAC
Sequence: MDGFDKTMKFSIQDEKQSVHVNDVLLTVYDALQEKGYNPINQIVGYLLSGDPAYIPRHKDARSIIRKLERDELIEELVKSYLKHHREE
What are the official names of this protein?
UPF0297 protein BAMEG_4652.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RL9_ECOLU
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y409_STRZP
Sequence: MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVSWLVFTGSLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDFVKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRLTFDELNELAENFSEN
What are the official names of this protein?
UPF0398 protein SPP_0409.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: ODO2_STAAS
Sequence: MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLASEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQANDDNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEEKKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFMKDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFVRDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAAILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLLES
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: UPPP_KLEP7
Sequence: MSDIHSLLVAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTANTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGKPPAHEGQGSGRLSLIHILLGMIPAVVMGLIFHDTIKSLFNPVNVMYALIVGGVLLIAAEVLKPKQPRAVGIDDMTYRQAFVIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATVLDVYKSIGFLNMGDVPMFAVGFVMAFIVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFB_STRPQ
Sequence: MLVSYKWLKELVDIDVTPAALAEKMSTTGIEVEGIEVPAEGLSKLVVGHVLSCEDVPETHLHLCQVDTGDETPRQIVCGAPNVKAGIKVIVAVPGARIADNYKIKKGKIRGMESLGMICSLQELGLSDSIIPKEFSDGIQILPDEAVPGDAIFKYLDLDDHIIELSITPNRADALSMRGVAHEVAAIYGKSVSFPEKNLQESDKATSEAIEVAIASDNVLTYASRVVENVKVKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDYDKFEDHKIVTRAARQGESLVTLDGEKRELTTEDLVITVADKPVALAGVMGGQATEIDANSQTVVLEAAVFDGKSIRKTSGRLNLRSESSSRFEKGVNYATVLEALDFAAAMLQELAEGQVLSGHVQAGQLSTEPVEVSTNLDYVNVRLGTELTFADIQRIFNQLGFGLTGDETRFTVAVPRRRWDISIPADLVEEIARIYGYDKLPTTLPEAGGTAAELTPTQALRRKVRGLAEGLGLTEIISYALTTPEKAIEFAVAPSHLTELMWPMSVERSALRQNMVSGMLDTVAYNVARKQSNLALYEIGKIFEQEVNPKEDLPNEVNHFAFTICGLVAQKDFQTQAQAVDFYHAKGILDTLFANLNLKVQYVPTKDLANMHPGRTALILLDEQVIGFVGQVHPGTAKAYSIPETYVAELDMAALEAALPSDQTFAEITKFPAMTRDIALLLDREVSHQAIVTAIESAGVKRLTKIKLFDVYEGATIQAGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITKALTEQVGAEVR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_LIGS1
Sequence: MALDLRNYIASIENYPEEGIVFRDISPLMADGEAYRQATDRIVQFAKDKGVEMIVGPEARGFIVGCPVAYELGVGFAPARKKGKLPRETVKADYSLEYGTASLYMHKDAVKPGQKVLVTDDLLATGGTIGATIDLVEQLGGVVVGCAFIIELEDLHGRDKIKGYDTLALMKY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM23_MOUSE
Sequence: MTIQKTGCRGREAAEVVEQRRRSHHCDDRKQTLLALLILVLYLGMGISGSSWEVSGQTKDCNHFQNPVTPQGFEYQTKEPAEEPLRTLRKWLKINLHGFLEKLEKEVRELEQLVRDLEFWLDALLGDLRPEDPCFT
What are the official names of this protein?
Small integral membrane protein 23.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LABA_JATMU
Sequence: AGVWTVWGTI
What is the function of this protein?
Labaditin is an active peptide which inhibits the classical pathway of complement activation in vitro.  Activity seems to be based on an interaction with C1.
What are the official names of this protein?
Labaditin.
Protein: PLSY_CLOAB
Sequence: MIIVIITVMVSFLCGSIPTGYLITKKLSGIDVRTKGSGNIGSTNVKRVAGTKISMITQVMDILKGIIPVLLCMLIASKIKLPISTSMYLSIIVIAVILGHDYTPFLGFNGGKGVNTTVGAFFLLAPAAVLAGAVVYFVLRLFTKIVSIKSIAVGITMPIACIALRLPIEITVCAIIACGLLILRHKDNLIRLVNNEEK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KCY_HALH5
Sequence: MKKMNIAIDGPAGAGKSTVAKQVAQALSFLYIDTGAMYRALTYAAIEHHVSPDDEASLKSLLDSIEIKLVDEQSKTRVYVNNTDVTDQVRTEEVTKTVSLVSSHGQVRKEMVRQQRLLAEGTNCVLDGRDIGTYVLPNAELKFFLTATVEERARRRYEENIQKGFKQSLEQLIKDIASRDEFDSNRSFAPLRKAEDAIEIDTTSLSISEVTQTIIGYVKERV
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
Protein: MO4L1_HUMAN
Sequence: MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400.  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.  Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones.  Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC).  Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
What are the official names of this protein?
Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPAP_HHV6U
Sequence: MCWSFHLFFKAHKARVGARTSFLTEMERGSRDHHRDHRDHREHRETREPPTLAFHMKSWKTINKSLKAFAKLLKENTTVTFTPQPSIIIQSAKNHLVQKLTIQAECLFLSDTDRFLTKTINNHIPLFESFMNIISNPEVTKMYIQHDSDLYTRVLVTASDTCTQASVPCVHGQEVVRDTGRSPLRIDLDHSTVSDVLKWLSPVTKTKRSGKSDALMAHIIVQVNPPTIKFVTEMNELEFSNSNKVIFYDVKNMRFNLSAKNLQQALSMCAVIKTSCSLRTVAAKDCKLILTSKSTLLTVEAFLTQEQLKEESRFERMGKQDDGKGDRSHKNDDGSALASKQEMQYKITNYMVPAKNGTAGSSLFNEKEDSESDDSMHFDYSSNPNPKRQRCVV
What is the function of this protein?
Accessory subunit of the DNA polymerase that acts to increase the processivity of polymerization.
What are the official names of this protein?
DNA polymerase processivity factor, Phosphoprotein P41, PP41, Polymerase accessory protein, PAP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae polymerase accessory protein family.
Protein: CDPK4_PLAF7
Sequence: MGQEVSSVNNTKNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGEDTSDLDNAAIEYEVDQILNSIDLDQNGYIEYSEFLTVSIDRKLLLSTERLEKAFKLFDKDGSGKISANELAQLFGLSDVSSECWKTVLKEVDQNNDGEIDFKEFRDMLVKLCNY
What is the function of this protein?
Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141).  Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite.  During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5.  Involved in merosome egress from host hepatocytes, probably together with CDPK5.  During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor.  Required for cell cycle progression in the male gametocyte.  During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation.  For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively.  Together with CDPK1, regulates ookinete gliding in the mosquito host midgut (By similarity).
What are the official names of this protein?
Calcium-dependent protein kinase 4, PfCDPK4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor.