PharMolix/UniProtQA huggingface dataset:
Protein: BRPF3_HUMAN
Sequence: MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL
What is the function of this protein?
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226).  Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551).  Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653).
What are the official names of this protein?
Bromodomain and PHD finger-containing protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: STX5_SCOVN
Sequence: AQTVRXDIPHHEXYAAGG
What are the official names of this protein?
Scolopendra 5924.74 Da toxin.
What is the protein family that this protein belongs to?
Belongs to the scolopendra toxin 5 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_BIFLO
Sequence: MVDIIDKALRMGEGHQLKKLENVAKAVNALEDEISALSDEDLKAQTPKFKQEIENGKSLDEIMPEAFATVREVSKRTLGQRHFDVQLMGGAALHWGNIAEMKTGEGKTLVATLPTYLNALEGRGVHVVTVNDYLASYQSELMGRIYRFLGMNVGCIITEQKPPERRKQYNADITYGTNNEFGFDYLRDNMAWEKADLVQRGHHYAIVDEVDSILIDEARTPLIISGPAEGDVTRWYRQFAKLVLKLTRDEDYDVDEKKKVVGILDPGITKVEDFLGIDNLYEPANTALIGYLNNAIKAKELFLRDKDYVVTQGEVLIVDEHTGRILPGRRYNEGLHQAIEAKEGVEVKAENQTFATITLQNYFRMYDKLAGMTGTAETEAAEFMNTYKLGVLPIKTNKPMIRKDQDDLIYRTKKEKLAAIVKDVAKRHAKGQPVLLGTASVESSEVVSTLLDVAKIPHQVLNAKQHEKEAAVVAVAGRKGAVTVATNMAGRGTDIMLGGNVEFLADAKLKSEGYSPEDTPEEYEKRWPGTLNEIKAQVKDEHEEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLEDDLMRLFNTQLVAQVMAKGMEEGQPIEAKSVTKGVRTAQKAVESRNYEIRKNVLKYDDVMNKQRTVIYSERQAVLKGEDIHKDILRFISDTVESYIKGANKGSEKPKDWDWEGLFKALNTVIPTKVDEDEVRKIVGGLKGAKAVEAVRDLIVEDARQQYGEMEETIGETGLRDLERRVVLAVLDRKWREHLYEMDYLKDGIGLRGMGQRDPLVEYQREGYQMYNSMIEAIKEETVQLLFHIDIKQVATTDEAVDEVEETAESADTIAVASGPDENGESVVEAAEGEVEEEDEDTDAKQAIAESAAASGAGESTLPVAGPAPISHAEGKVPVSKRPKSEELKTPWADGRTFPGTGKNAPCPCGSGRKYKMCHGQNEK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: TBA4_ARATH
Sequence: MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVSILLDNEAIYDICRRSLSIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAFHEQLSVAEITNSAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVGTIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGGDDEDDEGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-4 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TOS2_YEAST
Sequence: MFSHYRYKENSCQKREAIPDKSRVSLTFLQKRTDSSNVTVAVAVAVPIGAIIIVLSVVLIVVYRRCKKEPSMQDFDPNFEGDLYYLPKMDSSMNSANSDSNATEKRFIYGGYDDFLQPSIENSQSFKDYVRRINEHAPSAYNIASLASQNNSKLSVPSKHIDLSNKISFESLENSELIVSPQHSNTGQDCDQRCDSTSNPDVNEKSSHNNDNRLKSNYTSRSGLEPQCSREEEENIDRIRSIYNIYFEKSNSTIRSSVTSSIRRDSKLNIATRKSVNMSSQDNPNDTTLIEQSHFGSTTVQEIDSSSSANEEYEDATDYLQVPAPQENKNIASSVYSEVATREKVIPESSLSLTFPPPNGLSTRITSSIYSDTVAKDHIHSAKAPVRALSEGSGQSNLTSAQQYSTYFIDHCNQSNDDNYYYNYPLPLEHPQNYENIGDLPTPTQFIYSTSSHSLTSFKGRPKPPKTLKHVPTARLNGTALNPMDHPEMFYSSPTKIPSTSLTKQFCTPLPYQLRQSVVMTNPSELSMKPRYKPAGSLRNLIKAQYLPGNSSTTTSSSLSQPPSTLSNAINFRVSGLLDDTDILQPPSVGEILPFKASTEDLRKQLGTSHNYEITPYENVHV
What is the function of this protein?
Seems to be involved in the anchoring of CDC24 to the membrane of polarized growth sites.
What are the official names of this protein?
Protein TOS2, Target of SBF 2.
What is the protein family that this protein belongs to?
Belongs to the SKG6/TOS2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Bud membrane; Single-pass membrane protein.
Protein: RCAF1_HUMAN
Sequence: MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWEDKDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVCVADSFTTGHLDHLLHCHPL
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522).  Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522).  In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960).
What are the official names of this protein?
GEL complex subunit OPTI, Obligate partner of TMCO1 insertase, Rab5-interacting protein, RIP5, Respirasome Complex Assembly Factor 1.
What is the protein family that this protein belongs to?
Belongs to the EMC6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ENO_SOLM1
Sequence: MSTIAAVWAREILDSRGNPTVEVEVTLESGASGRAAVPSGASTGSREALEMRDQDASRYAGKGVTKAVENVQGELADTVIGMDALQQVAIDNLMIDTDGTENKSRLGANAILGVSLAVCRAASNFLGLPLYQYIGGINSKVLPVPMMNIINGGAHAPNNLDIQEFMIIPLGARTFADALRMGAETFHTLKKILAADGHMTAVGDEGGFAPNLKSHDEAFKYIIKAIEESGYRPGSEISLAIDAAASEFYKNGKYVLTGENLSLSSTEMVDYLGGFVERYPLISIEDGLAESDWPGWKTLTLNLGERIQLVGDDIFVTNPDILAEGIDQGVANSILIKLNQIGTVTETLDTIEMAKQAAYTTVVSHRSGETEDSFIADLSVAVNAGQIKTGSLCRSDRLAKYNQLLRIEEELEDMAIYYGPVMAGQWYEEEPEGDEE
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: LACG_LEPBD
Sequence: MSKKLPEDFIFGGATAAYQAEGAIKIDGKGPVAWDKFLEENYWYTAEPASDFYHQYPVDLKLCEEFGINGIRISIAWSRIFPNGYGEVNPKGVEFYHKLFAECKKRKVEPFVTLHHFDTPEVLHSNGDFLNRENIEHFVNYAKFCFEEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIKYDFEKLFQSHHNMVLAHAKAVNLFKKNGYHGEIGMVCALPTKYPYDPNNPKDVRAAELDDIIHNKFILDATFKGEYSKNTMEGVNHILQVNGGKLDLREEDFEELKAAKDLNDFLGINYYMSDWMAEYDGETEIIHNATGNKGSSKYQIKGVGQRKANESIPRTDWDWIIYPQGLYDQISRVKKDYPNYKKIYITENGLGYKDVFEDNTVYDDARIDYIRQHLEVISDAIKDGANVKGYFLWSLMDVFSWSNGYEKRYGLFYVDFETQKRYPKKSAYWYKKVSETKEV
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: WT1_RAT
Sequence: MGSDVRDLNALLPAVSSLGGGGGCGLPVSGARQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPSIRNQGYSTVTFDGAPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGMAAGSSSSVKWTEGQSNHGTGYESENHTTPILCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTKLHVAL
What is the function of this protein?
Transcription factor that plays an important role in cellular development and cell survival.  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'.  Regulates the expression of numerous target genes, including EPO.  Plays an essential role for development of the urogenital system.  It has a tumor suppressor as well as an oncogenic role in tumor formation.  Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors.  Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing.  Isoform 1 has lower affinity for DNA, and can bind RNA.
What are the official names of this protein?
Wilms tumor protein homolog.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus speckle. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus speckle. Note=Shuttles between nucleus and cytoplasm.
Protein: PFKA_LEIDO
Sequence: METRHHLNTKMVPSYQAPLSKVTAADLTVERLPGCKYMNPSKKHILREEYRDKVKHIMYDPRPQEDLDAEYPVSCNKLVCELAAARKHLHFNPSETSIGIVTCGGICPGLNDVIRSITLTGIISYRVKRVVGFRYGYWGLSKEGSKTAIELSRSDVRQIHRFGGTILGSSRGPQNPKEMVDTLVRMKINILFTVGGDGTQRGALTIYEEAKRPGENIAVFGVPKTIDNDLAFSHRTFGFQTAVEQAVNAVRAAYAEAVSLNYGVGIVKLMGRESGFIAAQTTVASAQANICLIPENPLPKETVMRLIERRLQQSRNCVIVVAEGFGQDWETGTGGHDASGNKKLVDIGFILKKEVESWLRANKEKFPQGTVKYIDPSYMIRACPPSSNDALFCTNLATLAVHEAMAGATGCIISMRYNNYILVPIKAATSVRRVVSLRGALWRQVREITVGLSDDVQQWNEQDLRRHLESLNVERERIIARLASKV
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
What are the subcellular locations of this protein?
Glycosome.
Protein: TNFA_MACFA
Sequence: MSTESMIQDVELAEEALPRKTAGPQGSRRCWFLSLFSFLLVAGAATLFCLLHFGVIGPQREEFPKDPSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALVANGVELTDNQLVVPSEGLYLIYSQVLFKGQGCPSNHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINLPDYLDFAESGQVYFGIIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: RS2_FINM2
Sequence: MSVVSMKSLLEAGVHFGHQTRRWNPKMSKFIFTERNGIYIIDLQKTVKQIDDAYNYVRDIVADGGEVLFVGTKKQAQEAIETEAKRCGQHFVSQRWLGGMLTNYKTIKTRINRLHKLYEMEEDGTFDLLPKKEVSQLEREREKLEKNLGGIRKMNKMPSVLFVVDPKKEYIAVHEAKILGIPVVGIVDTNCDPDELDIAIPGNDDAIRAVKLLTSTIADAVIEANQGREDSEDVYSETENDTEETDEELVSEEDLKEFVENSEEESDEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: THII_BACAA
Sequence: MMTYEYILVRYGEMTTKGKNRSKFVSTLKDNVKFKLKKFPNIKIDATHDRMYIQLNGEDHEAVSERLKDVFGIHKFNLAMKVPSELEDIKKGALAAFLQVKGDVKTFKITVHRSYKHFPMRTMELLPEIGGHILENTEDITVDVHNPDVNVRVEIRSGYSYIMCDERMGAGGLPVGVGGKVMVLLSGGIDSPVAAYLTMKRGVSVEAVHFHSPPFTSERAKQKVIDLAQELTKYCKRVTLHLVPFTEVQKTINKEIPSSYSMTVMRRMMMRITERIAEERNALAITTGESLGQVASQTLDSMHTINEVTNYPVIRPLITMDKLEIIKIAEEIGTYDISIRPYEDCCTVFTPASPATKPKREKANRFEAKYDFTPLIDEAVANKETMVLQTVEVVAEEEKFEELF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH3_DROME
Sequence: MSIYHDEVEIEDFEYDEEEEMYYYPCPCGDRFQISKEELIEGEEVATCPSCSLVIKVIYDPEMFKAEEDEESALNEKLGDLKLEKN
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph1 and Dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising Dph3 and a NADH-dependent reductase.  Acts as an electron donor to reduce the Fe-S cluster in Dph1-Dph2 keeping the [4Fe-4S] clusters in the active and reduced state.  Restores iron to Dph1-Dph2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM.  Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex.  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
What are the official names of this protein?
Diphthamide biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
Protein: EUTB_ECOLI
Sequence: MKLKTTLFGNVYQFKDVKEVLAKANELRSGDVLAGVAAASSQERVAAKQVLSEMTVADIRNNPVIAYEDDCVTRLIQDDVNETAYNQIKNWSISELREYVLSDETSVDDIAFTRKGLTSEVVAAVAKICSNADLIYGAKKMPVIKKANTTIGIPGTFSARLQPNDTRDDVQSIAAQIYEGLSFGVGDAVIGVNPVTDDVENLSRVLDTIYGVIDKFNIPTQGCVLAHVTTQIEAIRRGAPGGLIFQSICGSEKGLKEFGVELAMLDEARAVGAEFNRIAGENCLYFETGQGSALSAGANFGADQVTMEARNYGLARHYDPFIVNTVVGFIGPEYLYNDRQIIRAGLEDHFMGKLSGISMGCDCCYTNHADADQNLNENLMILLATAGCNYIMGMPLGDDIMLNYQTTAFHDTATVRQLLNLRPSPEFERWLESMGIMANGRLTKRAGDPSLFF
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds (PubMed:19762342).  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.  It is spontaneously inactivated by its substrate and reactivated by EutA (PubMed:15466038).
What are the official names of this protein?
Ethanolamine ammonia-lyase large subunit, EAL large subunit, Ethanolamine ammonia-lyase alpha subunit, Ethanolamine ammonia-lyase heavy chain, Ethanolamine deaminase large subunit.
What is the protein family that this protein belongs to?
Belongs to the EutB family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: ARND_SERP5
Sequence: MKKVGLRVDVDTFSGTREGVPQLLELFDKYNIQASFFFSVGPDNMGRHLWRLLRPKFLWKMLRSNAASLYGWDILLAGTAWPGRNIARALGPLMKLTAQAGHEVGLHAWDHQGWQAKVGRWSEAQLMQQVQLGVDALANSTGQPVKCSAVAGWRADTRVLEVKQRFGFHYNSDCRGTHPFRPVLSDGRLGTVQIPVTLPTFDEVIGSEVSMNDFNDYILREIENDRGVPVYTIHTEVEGMSQAAMFEQLLLRAQRQGIEFCPLSALLPQDLASLPLGRVERAPFPGREGWLGCQTDVKDDS
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: LPXK_METNO
Sequence: MRAPGFWWSVPTALPARLLAPLGRLYGGQVARRMARPGASAPLPVICVGNVTLGGAGKTPTALALAGLLREIGHEPAFLSRGYGGRLPGPVRVDPAQHGAAEVGDEPLLLARAAPTIVARDRPAGAALCAAADATAIIMDDGLQNPSLRKDWSIAVFDAGVGIGNGLAFPAGPLRAPLAAQWPHIDAVLIIGEGPAGEPVAADAVRRGLPVIRAQLRPEPGAAAALAGRPVLAFAGIGRPDKFFESLRAAGAEIRATRAFPDHHAYRAADLAGLERLARREGLTLVTTEKDRVRLPAAAPVTVLPVSLHFSEPDAALLRARLAALGPAPPDPRTRPD
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: DPOLX_ASFM2
Sequence: MLTLIQGKKIVNYLRSRLAFEYNGQLIKILSKNIVAVGSLRREEKMLNDVDLLIIVPEKKCLKHVLPNIRIKGLSFSVKVCGERKCVLFIEWEKKTYQLDLFTALAEEKPYAIFHFTGPVSYLIRIRAALKKKNYKLNQYGLFKNQTLVPLKITTEKELIKELGFTYRIPKKRL
What is the function of this protein?
Error-prone polymerase lacking a proofreading 3'-5' exonuclease which catalyzes the gap-filling reaction during the DNA repair process (By similarity).  Specifically binds intermediates in the single-nucleotide base-excision repair process (By similarity).  Also catalyzes DNA polymerization with low nucleotide-insertion fidelity (By similarity).  Probably acts as a strategic DNA mutase, which gives rise to a rapid emergence of variants (By similarity).  Generates mismatched G-G pairs, in that case, the polymerase first binds the deoxynucleotide followed by mismatch formation (By similarity).  Together with the viral DNA ligase, fills the single nucleotide gaps generated by the AP endonuclease (Probable).  Binds DNA with high affinity via the helix alphaE (By similarity).
What are the official names of this protein?
Repair DNA polymerase X, Pol X.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-X family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with viral nucleoid.
Protein: RLMH_MALP2
Sequence: MKIKIICFGKIKDKNITALINEYLSKINHFTNLTIVELSEEKINNENSIGEIEEALKKESKKLIPYLENSFNVLLDIKGVQMDSIKFANSINQNLIISKDINFYIGSSHGISESIKNKFNLKLSFSELTFNHQIFRLILLEQIYRAFSILNNTKYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOW_STAAR
Sequence: MYSIKMRSSNQDIHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIKQIKALQIIEDDKANLQHLTQKCGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGHRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYILFLESTPKQVVYETV
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: KAD_TREDE
Sequence: MNCIFLGPPGAGKGTLAFEVSKSYKIPHISTGDLFRAAIKEQTDLGKKVKAVIDSGALVSDDLTIALVKERLERDDTKKGFILDGFPRTIAQADALEDIVKIDSVINFDISDDEVIKRLSGRRVCSSCGQSFHIEFVKPKKEGICDSCSGDLMIRPDDKIEAIQKRLETYRNQTAPLIDYYTKKDLIVNIDARPASEKVLASFKVKFPH
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOT13_KLULA
Sequence: MEKAQIYGKLVDKESRCEHWHGPLDVIALRFKCCNGYYACYECHQELVPHVTERYNINDETVPLVICGVCKLEMSFAAYSDSLQCPNCRSQFNPGCKLHYDMYFMKDDEPENLR
What is the function of this protein?
Required for the assembly or recycling of the small Tim proteins in the mitochondrial intermembrane, thereby participating in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.
What are the official names of this protein?
Helper of Tim protein 13.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion membrane; Peripheral membrane protein.