Protein: IBPA_HISS2
Sequence: MNKNCYKLIFSKTRGCLVPVAECITSAVDSGSSDSVVVSEKTDEEDRQGSIEDYRLSNVCLSVKTFLNPVSSALCLNWKSVSVLLLSMVAAPNFAQSAEEAAKAEKTPKLTEIQNGNDGIQLETKNQNIGVGAGTTENNHPTKLYKTENNVIVIDIAKPNDKGISDNRFQKFNIPNGAVFKNNKDQQRSELVGYLEGNKNLADKEAKVILNQVTGSELSQIKGALEILGTKADLVIANQHGINLNGVQTINAGRFVATTSKLIDPNKMEFDVTQGTVTIDVNGFATDNLPYLDIVAKKIEQKGTIGNKEKEKNKTSETEITFIAGKGKIKYNIENDGKTKLEVQKDSNTSQPSDKEEVAITGASTGAMHGKSIKLIVTEQGAGVKHDGIILSENDIKIESNKGDIDLGDKLQAKNEISLNNAKRITIANEITADKSITITADDVKLKNNKEASATEEAKLKGKGKLASKKVKVEAKKSLVLDDETKVVATDLELKSQTLTNQGRIYGNKVKIDTDKLVNKKEIYAEDNLDITTKGKTVTVSVNKDNKRKADVKEETVADLDVGFENTGTIESKSKAKLTFKDNTSFVSKGNKFIKAKDELTIDAQNVVISENDELQTTARLTINAAGNVVNNGLLASGKTLTINAKQGSIYNEKGILGAREQLTLSAKGNNKETEGNIINGADSLLHSEGKMELDAENTVYNLGNIFAKSDLTVKANELINDVKLSGSITKKSPYSVLNRYRRSDIASHGWHNNDYRLWINPIEFEKAEVKVEKAGLIRAEGNFKFEGKKGDNQQDATLTNHGVINVKNTFEAQNAKVVNNMKAYQANLLTEFFKQKQDITFNYQPRARLFLSALSGQAERKFNSLEELFDGLFSEQPITNSSSYYADNSQAVHLLEEIKSPTFQKAMTLVFGANWKNEDHKKLSQRWKEFKEKQDAHFDYRPTDKAKILAQRINGKIDELKNGSTGGFSESERITVGQHKFDLSKVEFRSEVNRKENLNNSNVDLSALSDLLSIPNLFVDNSVQLDKTVDKNIEIDEEDEFLLKPHTGEEPDLLNENELSENGKFLDKLLGEIGEKTYIREVSDDWERDPDEPDEPDYKTESRLETRDRFDTLPSEVQDKLRQKFNEYKEKAQQKRQAEALQAKTKNEQLQSDLETGYKEEEKRQAKNDLEKQAELQQLDQQEKEKLAKEKELQGKINEEKQQEALAKQKQEQQKQADAKAKIEEEKRLEEYRKELAKDHQIEEALSKNQFLKEVDDTRPKVETDPLYRTKLQYINQDEYFGSKYFLNKVGSSTDAGKKVAVIGDNYLEHQLITKSIEKKVDNHLALKYQVNDAQLVKKLIDNSYFESKELGLKVGEALTKEQQNQLKQDIVWYVKANINNKEVLLPQVYFANKTLRDAEKFKGLGDALIRANEINLKTRDVLNSGTISGKNIDIEAENKIKNRGDILSEESTRLVGHKGIDNTARSFVNGNGDVEVQRASIRTEGHLHLEADEDSDINSKGSDIKGKTGFVKARNFNTTDTHRTEHSVEKGRIFSKKGEILGYRKESTQKAISVGSNTEFDHVHFAIKNDVNQEGSKIKAKVVTGVVQGDYNTKAGRNAQQTERYIRLDQEYSSGHISGAGFTVSHERDSQNGEKTNIGGASSNTGTGFTLGGSFSETREKETSLTHTNSDLQVDHGILHVLKKAEIGGVDINKHKFTGKAVEEDEAKAEQQAKAKAAPDATDNAAQKEEPKFKVLSQSEVDDLMTEKSANDLFNKYKKVKEDEGFELSAKEITSNKQKDEYHLDSERSVLKFGIETEGHSAIADAVSHVAKEIVEAQRGVKQDGTVALQHISDVANIVTGELVGGSSKFGFERNYETNKVKETSDIRTKIAGNITLSAHGGNLQLKNVESDANSKLTLQAKRNVDILDGETTRESTERQSRQKFAFGINSGCSVMSGGCNGGVSGSVDGNESFTTEKSVTHNNSLLRAKNLKIAAGKDLNLISSNIKADHLDLNIKGKTNIVSKQDSFDRLYRGFDFSASAGAALSSSTLVKGNGSFGAGYTHEVENRKLLNQQAGIVANRITGQIKDLDLVAAHFINKDENSGFRVSGNVTSQQLNDSHHKDGGSVGVSVGINERGASSFNVRGGRAEQKHYDAVQKSVISGINLKDNNVTGEIVDDLSKAKTVTRDDVYASTQFNFEVADLVELGEKAKSKLQSKFSKAVNNDAEQPTTTRISSEDVVEMVDNPLYGSNADVRKLRTLDEVGEGYSTLGDQNANKGRKLPNGSDDIYSLLGKVKVSGDEPVYDKVSAEGAYDLLGDSNANKGRTLRNNSDDLYSTVGDANSDISRIRSNVYDEIAAGPYSLLGRTKAAEEHIYEQIGEGPYSLLGNGSAVRNRTLGGESNSTYSTVGDANSDISRIRSNVYDEIVAGPYSLLGKPKAAEEHIYEQIGEGPYSLLGNGSAVRNRTLGGESDSPYSTVGDANSDISRIRSNVYDEIVAGPYSLLGRTKAAEEHIYEQIGEGPYSLLGNGSAVRNRTLGGESDSPYSLLGGEGTRNKVLADTIESIYSTLSRPQASSNLEMVDNPLYDSVRRSASDQLPELPTVRNLLNSDTEAGNGTYSEITSRTRNANDPLPPLPNEFRTRLSQGADLADHVYDTIGSIYSVLSKPKASSNLEMVDNPLYGSVRRAAGDQLPELPTVKTLLNKVEEVGNEIYSEITSKTRSANDPLPALPNFRLTQEVDTADHIYADINDVVNRANKAKRDLPATPEATPKVAVDGGDYATIGEVSPLQPRASRQQGSSDYEEIPLPQETAPQKTSPVKRTSAEGEDGYATIAEVLQPRAAKGQVSDYETIPLDEPSQAAVRTERSAVEGDYAEITSPSIQPRSARGQSGGEEFEPFPSEFSSEPQSPKRALPAENAVVNELGNELKARLKSKEDQANPAKAEVSEPIYATLDKSPEGLARAKAKGDEAAAANPIVKTRVEDDVAPELPARPSNLSDSISNETIAENGQSVALGTPKSAVAESNRNNNGNQKLQSEGAEGVSPKTKSEDKSWFAKVKDFFFAKSNKSQAKEAKSEQETVSKPNYDSLEDDLNLKNLLALEDKRGSSFEENVLKNPEFLAEAREIAKKYIPEATIKQMGNSPEFDEILTEGAKKVEKRINDALTFKPSVDEFNEIQGLVKNIQKGSAVDDLNAQTLAITEALADTSKTIQRNPKLKEEVQGAIEEFLKSSQGKELTVEMIEKLNHGLRPDEGSDRLLYKKENLTKENAVFSSPQASKIQLNETVDFINQAIKQNVEPSVLAGLVYQRLIAYHPFAEGNGRMARVVVNKILLDAGYPPFTKFSSEFETQIIPQTKATAKSATSAEVVKEFLTELGKKSSPQEGGANNQNGQATSPVTLKSKDVSEVENTQSADSLTIKQPEQGKAGGQLPSVPKVETSVNEVAPLSSVPAELKDAAGGNKKAAEKSEGATGVEKEKTTLFQRVKQFFTGSKSGAKPVAGDETANKVNYQDLEDNLNLKGLISLEDDRNANFESNVLKNEKFLDEAREISKKSIPEATVKQMSHLPEFDDILTEGAKKVESRINKAITFRPSVEEFSEIQDLVKTLPKTKVIEDLSTKTNEITEALAATSKTIQRTPELKEQLKTAIEDFLQNSQGKPLTVQMIENLNHGLRPDEGEGRLLYKKENLTKENAVFSSPEAAKIQLAETVDFINRAKNEGIEPSVVGALVYQRLIAYHPFAEGNGRMARVIVNKILLDAGYPAFTKFSDEFEPQIIPQTKASTKSATSSEVVVEFLKELAKKGSKEDNEQNLEKTDRTSTDLTESAVENSAALSSGTVRSATVSETVTETEQAKAKPVSDLVSSKDLVEQQRTVLQRIQDQFQPLKVKSKIDAVRSSVEEFGGEVSFKFAQSKGEVYKEIVKHIETQNGVCESTCAHWIAKNVNPTDENFFNTLYEGGKKGHLKKETIDSIKKLQTEFINSGSATQQFKLTDSWLQEQGVVPKEKKVADFVRRDEVSGTVSKNDVSSLVKAILDTGDDTAGVKKISINLEGGSHTVSAAVDGSKVTFFDPNFGEMTFPTHQQFENWLKNAFWQKSGYAGKQEGRRFFNVVNYKKNN
What is the function of this protein?
Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific tyrosine residue of host Rho GTPases RhoA, Rac and Cdc42.  The resulting AMPylation inactivates Rho GTPases, thereby inhibiting actin assembly in infected cells.  Probably also acts as a cysteine protease, which may play a central role after invasion of host cell and in virulence.  Possible member (with IbpB) of a 2 partner secretion.  Probably able to bind bovine epithelial cells (host cells).  May participate in the formation of fibrils at the surface of the bacteria.
What are the official names of this protein?
Protein adenylyltransferase and cysteine protease IbpA, HMW IgBP, p120.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase C58 family.
What are the subcellular locations of this protein?
Secreted. Note=High molecular weight-immunoglobulin binding protein IbpA, and probably other shorter forms. SUBCELLULAR LOCATION: [Protein p76 IgBP]: Cell outer membrane; Peripheral membrane protein; Extracellular side.