PharMolix/UniProtQA huggingface dataset:
Protein: MSP2_MYCSO
Sequence: MRLTYLPLFAGIAIQSASALPDFFKSSVLKPRRTNSLLINPDAQPDLPTAQQASTAAASVGLNLTDIQGDILIGMKKNKEMFFFFSIADATAFKSHLDSAILPLITSTQQLLTVATQPTTAVNLAFSQTGLNALGLASQGLGDSLFASGQFSGAESLGDPGTSNWVQAFAGTGIHGVFLLASDTIDNVNAELSQIQSILGTSITEAYRLQGEARPDDQQGHEHFGFMDGISNPAIDGFSTALPGQAVLSPGLFLLAEDGDGSSSSRPSWAKDGSLLAFRQLQQRVPEFNKFLADNAALTQGNADLLGARMMGRWKSGAPVDLAPTADDVDLANDPQRNNNFNFTHPDFTETTDQTHCPFSAHIRKTNPRSDFNPLNTANHIIRAGIPYGPEVTDAEASSNTSSTDASLERGLAFVAYQSNIGNGFAFIQQNWVDNANFFFGKTTPPGIDPIIGSNAAQNNFAPNSPRPVSGLDPTDSTTIVTLNTDFVVSRGGEYFFSPSLSAIQNTLSV
What is the function of this protein?
Peroxidase capable of degrading beta-carotene.
What are the official names of this protein?
Peroxidase 2, MsP2.
What is the protein family that this protein belongs to?
Belongs to the DyP-type peroxidase family.
Protein: WAG1_ARATH
Sequence: MEDDGYYLDTDLDLSFTSTATDRTFTSSSARSSLARSSLTLSFNDRLSTATTPSTTTSSAATTLHHRRYDPHWTSIRAATTLSSDGRLHLRHFKLVRHLGTGNLGRVFLCHLRDCPNPTGFALKVIDRDVLTAKKISHVETEAEILSLLDHPFLPTLYARIDASHYTCLLIDYCPNGDLHSLLRKQPNNRLPISPVRFFAAEVLVALEYLHALGIVYRDLKPENILIREDGHIMLSDFDLCFKADVVPTFRSRRFRRTSSSPRKTRRGGGCFSTEVEYEREEIVAEFAAEPVTAFSKSCVGTHEYLAPELVAGNGHGSGVDWWAFGIFLYEMLYGTTPFKGGTKEQTLRNIVSNDDVAFTLEEEGMVEAKDLIEKLLVKDPRKRLGCARGAQDIKRHEFFEGIKWPLIRNYKPPEIRGLVKKTKAHAGHVTAAVTPRRNKWLWWALSHLLRSKSLSKSSSKIQSNNNYYHYVGKKL
What is the function of this protein?
Serine/threonine-protein kinase involved in the regulation of auxin signaling.  Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing PIN-mediated polar auxin transport.  Phosphorylates conserved serine residues in the PIN auxin efflux carriers.  Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis.  Acts as suppressors of root waving.
What are the official names of this protein?
Serine/threonine-protein kinase WAG1, Protein kinase 3, AtPK3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: COSA_ARATH
Sequence: MNVDEEIQKLEEEIHRLGSRQTDGSYKVTFGVLFNDDRCANIFEALVGTLRAAKKRKIVAFEGELLLQGVHDKVEITLRPTPPPPQAAAATAASS
What are the official names of this protein?
Costars family protein At4g33640.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: VSM5_TRYBR
Sequence: MIGKAFIILSLLNELPTPTAAQAAQGGALGKDVWLPLAKFTATAAKIPGRAAKLLQDRSAQIVNLMKLQVQADICLNKAASEVSALGWQALAVAIAADIGSLQSLQQQRSEEAIAAAAAAEFARGHAAEFFKVAAAVQSAANSGCLTTNNKGGAAGSVINGFSTLGTAEQPAIGATSTAHVGDDITAITTTGFSDLAATDGIRTDSLTADTNCVLFKGGSDGPLTTANFGQSIPFAGGYLTRNPTANTASSADGTDFVSNPEDSKIAGIKVYRDAHAAAAKIRTAATFGSTFTDFKKLDQAKKSVHLRAAVKNIILGKPDGSVDDLSGEIDTKINQVFGEDQETFHSRFWDQLTKVKVEKAASGQEETTLDAITSFAALSRARTYYSTKVIKGLRDKISSLEIKNSKTEVKVTDADCNKHQSKDKCAAPCKWNENTTDINKKCSLDPVKATEQQAAQTAGAGEGAAGTTTDKCKDKKKDDCKSPDCKWEGETCKDSSILLNKQFALMVSAAFVALLF
What is the function of this protein?
VSG forms a coat on the surface of the parasite.  The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
What are the official names of this protein?
Variant surface glycoprotein MVAT5, VSG.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=A soluble form is released from ruptured cells by the action of a PI-PLC.
Protein: MQNC_HALH5
Sequence: MSIDGILERAVNGERLSMEDAVKLYESDEVEKMGAAANQIMLKWHPEPITTFVIGRNVNYTNFCDTYCRFCAFYRAPGHKEGYVLDDEVILKKIQETIDVGGTEILMQGGTNPDLTIDYYTDLLRNIKERFPNIWMHSFSPAEVWKIAEVSSMSVEEVLRELHEAGLDSMPGGGAEILTEETRLRVSRLKITWEQWINAMKATKKVGMHGTATMVIGFGESFEERALHLQRVRDAQDETECFTAFISWLFQPENTGMYKTKKLTPRDYLKNVAISRLFLDNIPNFQSSWVTMGPEVGKLSLQYGCNDFGSTMIEENVVSAAGTTHKVNTNKILQLIREAGKIPAQRTTSYEIIRTFEDKEAAEKDFVMQN
What is the function of this protein?
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
What are the official names of this protein?
Cyclic dehypoxanthine futalosine synthase, Cyclic DHFL synthase, Dehypoxanthine futalosine cyclase, DHFL cyclase, Menaquinone biosynthetic enzyme MqnC.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MqnC family.
Protein: RL9_MYCTU
Sequence: MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ISPH_BAUCH
Sequence: MRILLANPRGFCAGVERAINIVEKVIAIYGPPIYVRHELVHNSYVVNTLRNQGVVFIEQIHEVPDGAVIIFSAHGVSKAIRKEVQSRNLTIFDATCPLVTKVHMEVARASHKGIETILIGHYGHPEVEGTIGQYNNTDGGIYLVESLEDVWQLKVKNKNNLCFITQTTFSVDKSSAIIDALRQRFPFIKGPHKQDICYATTNRQEAVRNLTMATDIVLVVGSKNSSNSNRLVELAQQTGKPAYLIDCASDIKENWLQGINIIGVTAGASAPNILVLQVILKLQSFGAESAEELRGYEEKMIFDLPRNLHVVNK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: MURD_HAEIG
Sequence: MNAYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKNPTGIDKLPQNIPLHTGSLNQEWLLESDMIVISPGLAVKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDCELYVLELSSFQLETTYSLKAAAVTVLNVTEDHMDRYMDLEDYRQAKLRIHHNAKVGVLNNEDRLTFGENENQAKHTVSFAENSADYWLKTENGKQYLMVKDEVILPCEEATLVGRHNYMNILAATALAQAIGINLDSIRTALRHFKGLDHRFQLVHQANGIRWINDSKATNVGSTVAALAGLYIEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGAQLAKFSSQSYLFETMEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQYSV
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP2_ARCFU
Sequence: MKGLPPSLRSRKRYIAFRIIAEKKIDERSLSRALSEKMLSLFGECFAASGLRLEAFDGERGIVRCYREALDKVMVALTLMTHVGGVRVIPLTLGVSGTIKRCKRKYLEV
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_RHOPA
Sequence: MREPGFWHRPPSLVSRLLLPIAAIYGNIAAARMQKAGTTVGVPVLCVGNYHMGGAGKTPTTLALVALLREFGETPVVLSRGYGGRLQGPVQVDPSRHSAADIGDEPLMMARRVPVVVARDRTDGAALACALGATVILMDDGFQNPALTKDASLIVVDSHRSIGNGSVFPAGPLRAPLPLQVARTDALVVVGDGTAADGLAQQITTKGGVVLRARLVPEPASVEALRGRRVLAFAGIGDPARFVATLRDSGVEVVEQRAFADHHPFTAEELAELAAAAKRDGLTLVTTEKDLARIGGAQQALGVEIVPFAVTLAFGDEAKLRLFLLDRLNGARAAKLAGRR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MACB1_YERPS
Sequence: MAALLELEGIRRSYQSGEEIVDVLQDVSLTINAGELVAIIGASGSGKSTLMNILGCLDKPSAGIYRVAGQNVDELDDDALAALRREHFGFIFQRYHLLPHLSAAHNVEVPAVYAGLGKHERRERANMLLTRLGLGDRVSYQPNQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSSVEVMAILKQLQQQGHTVIIVTHDPTVAAQAERVIEIKDGRIMADSGSKNEPVVAAAELMSLTPAAPSWQQLVGRFREALLMAWRAMSANKMRTALTMLGIIIGIASVVSILVVGDAAKQLVLADIRAIGTNTIDIYPGKDFGDDDPSTRQALVHDDMAALKAQSYVSAVSPSIGGSMRLRFGNIDVAASVLGVSDEYFRVFGMAMEQGAPITREQVERQAQTVVIDLNTQRRLFPHMKDVVGQVILVGNMPATVVGVVAEKKSMFGSNKALRVWVPYSTMANRLMGRSYFDSITIRIKEGYSSKEAEQQLVRLLTLRHGKKDIFTYNMDSLLQTAEKTTQTMQLFLTLVAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARSSDVMQQFLIEAVLVCLIGGALGISLSFAIGLIVEMFLPNWRIAFPPMALFSAFLCSTVIGVVFGYLPARSAARLNPIDALARE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FOLD_SPICI
Sequence: MDKTKIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGVTCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGFTPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLLINASATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDEDNNLCGDIDFHNVFSKVKMITPVPGGVGPMTIAALLENILYFYQLNQKI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL7_RHIME
Sequence: MADLAKIVEDLSSLTVLEAAELSKLLEEKWGVSAAAPVAVAAAGGAAGAAAPVEEEKTEFDVILTDAGANKINVIKEVRAITGLGLKEAKDLVEGAPKAVKEAVSKAEAADLKKKLEDAGAKVDVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: MUB6_ARATH
Sequence: MAGEEDWIELKFRLADGTDIGPSKYNQSMTVSSLKEKLISQWPKDKENTPKTVNDMKLINAGKILENNRTLAESRLPVCELPGMIITMHIVLRLPTLDKKSEKLQNDPPMKNRCVCTIL
What is the function of this protein?
May serve as docking site to facilitate the association of other proteins to the plasma membrane.
What are the official names of this protein?
Membrane-anchored ubiquitin-fold protein 6, AtMUB6, Membrane-anchored ub-fold protein 6.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RLMN_SHESW
Sequence: MSEKKINLLDLDRKAMRALFADLGEKPFRADQLMKWIYHFGVSDFEEMTNINKVLRQKLAARCEIVAPEISSFQKSTDGTIKFAIHVGEGQEVETVYIPEDDRATLCVSSQVGCALECTFCSTAQQGFNRNLTVSEIVGQIWRVSHFLGFAKDTGDRPITNVVMMGMGEPLLNLANVIPAMDIMLDDFGFSLSKRRVTLSTSGVVPALDKLGDALDVALAVSIHAPNDELRDILVPVNKKYPLQEFLAGIRRYIAKSNANRGRVTVEYVMLDHINDSTEQAHELAKLMKDTPCKVNLIPFNPYPGSPYGRSSNSRIDRFSKVLMEYGLTVIVRKTRGDDIDAACGQLAGDIRDRTKRLAKKRMQENQISVTMN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_SALPA
Sequence: MHFTATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGLGILASKFVLEWNHWIAFVLLIFLGGRMIIEGIRGGSDEDETPLRRHSFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMIGRFIGPMLGKRAEILGGVVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPIS_PROMH
Sequence: MRHPLVMGNWKLNGSIHMVHELIAALRKEISGVAGCDVAIAPPTVYLCQARHEIGGSRIALGAQDTGVNLSGAFTGETSPEMLKNVDVKYVIIGHSERRTYHKESDEFIAQKFGVLKELGLTPVLCIGETEAENEAGKTQEVCARQIDAILNAHGAQAFKDAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAIAEQVIIQYGGSVNDKNAAELFSQPDIDGALVGGASLKADAFAVIVKAAAEAKAKK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_ECO57
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKAVEALMARNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: RIBA_VIBVU
Sequence: MAEVRARVDFKVGAKSNIDAEILSFRGLKTDKEHVAVIFKSADVTQEVPLVRMHSECLTGDVFHSSRCDCGEQLEETINRMGESGGIILYLRQEGRGIGLYNKIDAYRLQSEGMNTYEANNHLGFDDDLRDFTEAAQMLEALGIKQIRLVTNNPKKIRELSEYGIEIVEVVNTSAHIKEGNESYLKAKVSHGKHHLKV
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: RECO_ACIF5
Sequence: MTTEPGDRAWVLHHYPYGDTSLIVELFTRTQGRLGVLAKGARRARSALARIEAGRPLWVRWLGRGELPVLAQAEELGPFLPLNPLQNLSLFYVNELLLRLTQRRDPFPDLFQVYEETIDALCSEPGEGWYLRRFERRLLENLGWAPDLAHCAECGRSPDAASSEHWLYQAAHGVFCRAHAPDAAVAIEAAALVWLRGAMQTRSMPVWNSSLRRCLEQELLVHLGGRPLESRRLLTAYLRRTQPAMTIQKREEHSE
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: PYRH_CARHZ
Sequence: MPSPKYKRVVLKLSGEALAGEKGYGIDPEVVNSIAGQIAEIIKEFGIQVAVVVGGGNIWRGLSGSAKGMDRATADYMGMLATVINSLALQDALEKLGIDTRVQTAIEMRQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKRVDGVYDSDPLKNPNAQKFDELEYIEVLNRGLGVMDSTATSLCMDNNIPLIVFNLEVPGNIKRVILGENIGTIVGGERK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_RHOCA
Sequence: MGVMTGSNTAAVDMDVAAAALNRDLQDKGFLLTTAEDIINWARNGSLHWMTFGLACCAVEMMHTAMPRYDVERYGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPSAEALMYGILQLQRKIRRTGTLVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TSN12_BOVIN
Sequence: MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGSLLVIFCVELACGVWTYEQEIMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMMALKNDTTQHLPCHSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
What is the function of this protein?
Regulator of cell surface receptor signal transduction.  Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction.  Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs.  Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1).  Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP.  Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP).  Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity).
What are the official names of this protein?
Tetraspanin-12, Tspan-12.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUFP_RICCO
Sequence: MATDLSSSSTLLLSRNCKTPPFYHTTNSLSLSKTHHLYASRNAVVSRLRLLCQTTGSTQSTPTSGVSDLQFAAQVGQHRLSKVPISNIRNFCIIAHIDHGKSTLADKLLQVTGTVQQREMKEQFLDNMDLERERGITIKLQAARMRYVYENKPYCLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKIDLPGSEPDRVIQEIEEVIGLDCSNAIRCSAKEGIGIIDILNAIVERIPSPRNTAEMPLRTLIFDSYYDPYRGVIVYFRVLDGSIKKGDRIYFMASKKDYFADEIGVLSPNQMQVEELYAGEVGYLSASIRSVADARVGDTITHYNRRAQSSLPGYKEATPMVFCGLFPVDADQFPEVRDALEKLQLNDAALKFEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYNLSLITTAPSVVYRVNCVDGDTVECSNPSLLPEPGKRRSIEEPLVKIEMLTPKDYIGPLMELAQDRRGEFKEMRFITNSRASITYELPLAEMVGDFFDQLKSRSKGYASMEYTFIGYKESDLIKLEIQINGDPVEPLATIVHKDKAYPVGRALTQKLKELIPRQMFKVPIQACIGSKVIASEALPAIRKDVLAKCYGGDISRKKKLLKKQAEGKKRMKAIGKVDVPQEAFMAVLKLEKKPWSYKYKMSVNC
What is the function of this protein?
Promotes chloroplast protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
What are the official names of this protein?
Translation factor GUF1 homolog, chloroplastic, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYT_ECO45
Sequence: MPVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN_NASOF
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MEPCE_HUMAN
Sequence: MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGASQQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSSYELVATPHNTSKGFQRPVYLFHKARSPSH
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425).  Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375).  The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838).  In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723).  MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723).
What are the official names of this protein?
7SK snRNA methylphosphate capping enzyme, MePCE, Bicoid-interacting protein 3 homolog, Bin3 homolog.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.