PharMolix/UniProtQA huggingface dataset:
Protein: IXTPA_PSEAE
Sequence: MIKLEQLVLASHNAGKLKELQAMLGASVKVRSIGEFSQVEPEETGLSFVENAILKARNAARLSGLPALADDSGLAVDFLGGAPGIYSARYADGRGDAANNAKLLEAMKDVPDAERGAQFVSVLALVRHADDPLPILCEGIWEGRILREARGAHGFGYDPLFWVPERDCSSAELAPEEKNRLSHRARAMALLKQRLGL
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: OPCA_SYNE7
Sequence: MTTATPLLSLQKPTPIALAEIEESLSQLWANQQHSGAGALVSRAATFSIVVYEPEEFQQILAALGLYHGHLDGLHGPMTRAAIAQAQTQFGLPSTGRPDSATFKALRQAYQALKHSPSLTNQDLRGAVLSNVIATQNPCRIVSLCPTLEGDRPISAEVSAYCPITSAKQASLICCEAVTLRGSQAEMEAIGTFVSELLLPGLPRYVWWKATPNPEQLLFQQLANSCNCMIFDSSYFSDPEAEFLRFQDLIDQETYIADLNWHRLAAWQELTAAAFDPPERRDGLLEVDQLVIDYEKGNPAQALMYMGWIASRLGWQPVSYRCEGGEYDLRQIEFRTEDDRMVKVELAGIPVGDPGLVLGDLIALRLTSENPDADCCTILCSETTGCMRMEAGGGAQSCRTEQVAPPSNETSESLLAMQMQRWGRDALYEESLAVIAVALRQRTHA
What is the function of this protein?
May be involved in the functional assembly of glucose 6-phosphate dehydrogenase.
What are the official names of this protein?
Putative OxPP cycle protein OpcA.
Protein: SPEE_XANOM
Sequence: MSTNDNWYIEHFQPTGSAIGFRISGKLDEVQSLFQKIEIYQTTDWGKLMLIDGAVMLTSRDNFFYHEMISHPALFTHPTPKRVVIIGGGDCGTLREVLKHPGVESATQCDIDEQVTRMSEKYFPELCDSNHDARAELLFDDGVAYMANCPAGSVDIVIVDSTDPVGPAEGLFNKAFYESCFKALKDDGLLVQQSESPLALLDLIKEMRTEMGKAGFQSFKTLPFPQPCYPTGWWSVTMASKQAKADFAFRQGAAQAKGFETLYYTAHLHTGVLVAPPFVAKALGE
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFLA_STAES
Sequence: MLKGHLHSVESMGTVDGPGLRYILFTQGCLLRCLYCHNPDTWKINEPSREVTVDEMVNEILPYKPYFEASGGGVTVSGGEPLLQMPFLEQLFKELKANGVHTCIDTSAGCVNDTPAFNRHFDELQKHTDLILLDIKHIDNDKHIKLTGKPNTHILKFARKLSDMKQPVWIRHVLVPGISDDKEDLIKLGEFINSLDNVEKFEILPYHQLGVHKWKNLGIPYQLENVEPPDDEAVKEAYRYVNFNGKIPVTL
What is the function of this protein?
Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
What are the official names of this protein?
Pyruvate formate-lyase-activating enzyme, PFL-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_SALPK
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRGELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: END8_ECODH
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKPYQSQLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTGEEPQTTRVLRVKLQTADKTILLYSASDIEMLTPEQLTTHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLEIPRFSYATRGQVDENKHHGALFRFKVFHRDGEPCERCGSIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RL1_SHEPC
Sequence: MAKLTKRMRVIREKVDGTKLYEINDAVALLKELATAKFVESVDVAVNLGIDPRKSDQNVRGATVLPHGTGRDVRVAVFTQGANAEAAKAAGAELVGMDDLAEQIKAGEMNFDVVIASPDAMRVVGMLGQILGPRGLMPNPKTGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFTPVQLKENLEALISALKKAKPAVAKGVYVKKVSISTTMGAGVAVDQATLDTAN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CBID_BURCH
Sequence: MRDETPEQPAPLRFGYTTGSCATATSLAAARLLLAGQADDAVEIVLPKGQRVMMRLEFCRATADGAEAGTIKDAGDDPDVTHGALIFARVALAAAPGVRFHAGPGVGTVTRAGLTLPVGEPAINPVPRQMMTTHLEALAAEHGYAGGFDVTIGVEGGEALALKTMNPRLGIVGGLSILGTTGIVRPFSCSAYIASIHQGIDVARANGIAHIAACTGNASEDAMRAHYQLPDMALIEMGDFAGAVLKHLRRAPVARLSMCGGFGKLSKLAAGHLDLHSRHSSIDLPLLAQWAAEAGANEALQAAMRAANTSQEALKLAQADGVPLGDLVCAHALRVARDIVPPSVAVEMFAIDRQGRFVGAAR
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: BAG5_RAT
Sequence: MDMGNQHPSISRLQEIQREVKSIEQQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQDTERLLKELEQNANHPHRIEIKNIFQEAQALVKEKTVPFYSGSNCVTSEFEEAIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQEIIEDCVRKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLMADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADNTHAFDLGQNHSIIKIENVLKRMREMKNELLQAQSPPELYLRSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYLDLKEALEKRKLFPCEETPPHKAVWNVLGNLSEIQGEVLSFGGNRTDKNYIRLEELLTKQLLTLDAVDPLGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY
What is the function of this protein?
Co-chaperone for HSP/HSP70 proteins.  It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity).  Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity).  Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (PubMed:15603737).
What are the official names of this protein?
BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5.
Protein: PROB_GEOSW
Sequence: MKKQRVVVKIGSSSLTDAKGALCHEKLFDHVESIAYMKQLGHEVILITSGAVAAGFGPLGYPSRPTTTAGKQAAAAVGQGLLMQGYISAFKQFGITTGQILLTREDFYSRERFHNLFSTITTLLACGVLPIINENDSVSVEELTFGDNDMLSALVSGFLHADALIILTDINGLYDDNPKTNPKAKKYAFLPNITDEMIEAAGGSGSAVGTGGMKSKLLAAQKALSFGVSVFVGTGAGKEKLCDILEGKGDGTYIGAPFHGHMQMRKQWIAYHAPVAGKIEIDEGAETALLQRGKSLLPAGVTAVYGNFSAMDVVEVVNRKGAVIGRGQVYYSASDLEQIKGLSSNEARKYSINHRPEVIHRDNWVSLRKESVVK
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA_ACTPJ
Sequence: MNNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSN
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_METAC
Sequence: MSQSKPDTGNEIETQKQELIAALKACGAVRYGDFTLSSGKKSKYYIDIKKASTDPKTLKIIARQAALRVKEMGVGTVAGVELGGVPLATAVSLETGLPLLIVRKSVKEYGTKSRFVGDLRPEDRLVMLEDVTTSGGSVRDAIKVVRETGACVKYVITVVDREEGAKEKLKEADAELVPLVTASDLLK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PLSY4_DEHM1
Sequence: MPLLFVLLSYLLGTFPSAYLAGYLSTDRDIRLMGDHNMGAQNAYRCLGRGWGLAVFVFDLAKGSLAITLALAAGLSPGWVMFCGLAAVLGHNWPVWLGFRGGRGEATAIGVMLLIATQPMLIMGGLGLLVLLFTSSVIAASAVMFGLLWLAVILYGLPGGVVAYSIGLPVVVGLTHFIRSRKNRL
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 4, Acyl-PO4 G3P acyltransferase 4, Acyl-phosphate--glycerol-3-phosphate acyltransferase 4, G3P acyltransferase 4, GPAT 4, Lysophosphatidic acid synthase 4, LPA synthase 4.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TREB_MAGO7
Sequence: MSEAPQARRVGSVDDHSVYDDAKTYYTSEERHNNSRSGPRQRTYSQNSLLGQMERLGLKEPFRRGSHDESNHNRRFLIQVDPTLESLKSQEDTDGNMQITIEDNGPKVLTLRTAGSNGHNRFDIRGTYMLSNLLQELTLAQEYGRKQVILDEARLNENPVNRLSRLIRDHFWDALTRRIDASSIEVAAKDPKDWTDDPRPRIYVPKGAPEQLEYYKKLAADKPDIRLDVVELPETITPEYVVGINKAPGLLAVDMEETVDPKTGERVMSGRPFVVPGGRFNELYGWDSYMESLGLLVNDKVYLAKSMVLNFCFCIKHYGKILNATRSYYLCRSQPPFLTDMALRVYDKIRHEPDATEFLRTAILAAIKEYHSVWVAEPRLDPVTGLSRYRPEGTGVPPETEADHFLHILEPYYKKHNMTFKEFVEAYNFGRIREPELDKYFLHDRAVRESGHDTSYRLEGVCADLATVDLNTLLFKYETDIARTIRNVFGDKLVIPAEYCVGSLQPGQVETSAIWDRRSKRRKLAIDKYLWNEEAGMYFDYDTAKRQQCNYESCTTFWALWAGVASPKQAAIMVTRALPKFEAYGGLLSGTEESRGQIGLDRPNRQWDYPYGWAPQQMLAWTGLYRYSFTEEAERLAYKWLFMITKAFSDFNGVVVEKYDVTRPVDPHRVDAEYGNQGLGFKGVAKEGFGWVNASYIYGLQIINAHMRRALGTLTPYDTFIKALEDNRNRALSEMV
What is the function of this protein?
Hydrolyzes intracellular trehalose to glucose (By similarity).  Plays a role in pathogenicity, specifically in proliferation of invasive hyphae in rice blast disease (PubMed:12514128).
What are the official names of this protein?
Cytosolic neutral trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCN2_DROME
Sequence: MVYFGDRQRDRNRDRSNQKVERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADKSNTENGNHA
What is the function of this protein?
Voltage-gated chloride channel.  Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
What are the official names of this protein?
Chloride channel protein 2, ClC-2, DmClC-2, Chloride channel-a.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y2880_XANCP
Sequence: MSVALTTLLLFVATAVAELVGCYLPYLWLRKGGSVWLLLPAALSLAVFVWLLTLHPAASGRVYAAYGGVYIATALLWLWWVDRVTPTRWDLLGAGCCLLGMAIIMFSPRSG
What are the official names of this protein?
UPF0060 membrane protein XCC2880.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEF_ACTSZ
Sequence: MNRYDNSLSGLKLGQKTEYNAKYDRTLLQPVPRRLNRDDLGISAQQPFNQGADIWTAYEISWLNPKGLPQIAIADAEIDFRSENLVESKSFKLYLNSFNQTKFASPAEVQDTIRRDLQDCVQGEVKVRLNSVAFYTHQPIHELSGEIIDNQDIEISDYGFNAELLTNCTCDVQVEETLVSHLLKSNCLITGQPDWGTLQIRYAGNRIDREKLLRYIVSFRQHNEFHEQCVERIFCDILHYAEPEKLTVYARYTRRGGLDINPFRSNFEPVPGNFRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRBP2_HUMAN
Sequence: MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS
What is the function of this protein?
Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062).  Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').  Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:7903453, PubMed:12177166).  Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062).
What are the official names of this protein?
Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2.
What is the protein family that this protein belongs to?
Belongs to the SREBP family.
What are the subcellular locations of this protein?
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus. Note=Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import.
Protein: Y2234_OCEIH
Sequence: MAKMTTIKMKRLLEDRLKNPEYRIVYKRDDDALRIEWRDSGQGMTVSLPNLITKYNNRGDIAIQEMEEHIIEALKIMNETHHLQGMEKHIFPVLRSPSFPIETKAGKKLIYKDHTAETRVFYALDLGKSYRLIDEELLKEEEWTLDRLDEIASFNVRSLSHEVKKDQVADNDFYFLATQDGYDASRILNEAFLEEMKANAQGELTVAVPHQDVLIIADIQNKMGYDILAQMTMKFFAEGRIPITSLSFVYEDRKLEPIFILAKNKPEK
What are the official names of this protein?
UPF0354 protein OB2234.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: PSAB_CAPBU
Sequence: MALRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFETWVQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGALGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSALSLIGGWLHLQPKWKPRVSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGENVRWNNFLNVLPHPQGLGPLFTGQWSLYAQNPDSSSHLFGTSQGSGTAILTLLGGFHPQTQSLWLTDMAHHHLAIAILFLIAGHMYRTNFGIGHSIKDLLEAHIPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTSYGFDVLLSSTSGPAFNAGRSIWLPGWLNAINESSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWKDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS2_LISMC
Sequence: MPVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAFNFMREVASDNGTILFVGTKKQAQESVRDEAIRSGQYFVNHRWLGGTLTNFETIQKRIQHLKKIERMEADGTFEVLPKKEVVLLKKEQEKLERFLGGIKDMKGLPDALFIVDPRKERIAVAEARKLHIPIIGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAIIEVNQGEELTEAEVAPVEEKATEETTEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NDK_CERS1
Sequence: MAIERTLSIIKPDATRRNLTGKINAKFEEAGLRIVAQKRIHLSLAQAQKFYGVHKDRPFFGELTEFMASEPVVVQVLEGEGAIAKNREVMGATNPANADAGTIRKEFALSVGENSVHGSDAPETAAEEIAFFFSGLELVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYM45_MELRA
Sequence: MESNKMVVGVLLIAAFALPALALFERDVITHETIEAVLKKSTPNSNTMLQEDAINALTGKTLISQTILEETLLKNGVVGGSIPCGESCVYIPCISSLLGCSCKSKVCYKNSLALPTLEKDVITPEALEAVLKSNGGAIVNTKTIISNAIFEETLLNNANHVLGGIPCAESCVYIPCLTSAIGCSCKSKVCYRNSLALN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotides mra4/mra5.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: HEM3_CLOAB
Sequence: MKLTIATRKSKLAQVQTELIINVLKDKYGISSEKLLMETLGDKILDKSLADIGGKGLFIKDIERILLEDKADAAVHSMKDVPFEVPDMFEIAAVTLRVDVRDVFVSRDGTHFKDLKNGAVIGTSSNRRAAQLKMLRDDIKVVPIRGNVQTRIRKMGEEKLDGIILAAAGLKRLNMENIITDYFSVEEMIPAVGQGALGVEIKKENKNRDLFRKLDNKNSRMCVEAERSFMRTLNGDCHSTIGAYAEIVNGQMNVLGFYEIDGRRVKKDVSGNIEDYMSLGKTLAEKILEDK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: 4HYPE_SHELP
Sequence: MLKGTFFCVDAHTCGNPVRLVTSGHPDLKGRTMSEKRQDFLAQYDWIRKALMFEPRGHDMMSGAFLYPPCSDNADAAILFIETSGCLPMCGHGTIGTITAALESGLLTPKMPGQLTIDVPAGQIKVQYQQTGAKVDWVKIFNVPAYLAHKDVVLDIPGLGPLKIDVSYGGNYYAIVDPQANFPGLRHWSAGDILRWSPIVREVAHRELNCVHPDDPTVNGVSHVLWTGDTISEGSNGANAVFYGDKAIDRSPCGTGTSARLAQLYSRGELKVGDEYTHESIIGSQFVGRIEAATKVGAFDAIMPSIKGWARITGHNAITVDDNDPYAFGFQVV
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate.  Displays no proline racemase activity.
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: GLMU_BART1
Sequence: MVRSCLSIVLSAGEGTRMKSPLPKVLHKIAGLPLICHVLKQIELAESSQVAVVVGCGGQEVTHVVQSFVKDVMIFEQKERLGTAHAVLSARFALQKGVDDILIVFGDTPLIQQESLHQMRAQLADGADVVFAGFHTQDPTGYGRLLEKNGQLIAIVEEKDASEEEKKISFCNGGILAMRGKHALSLLEKVDNNNMKKEYYLTDIASLASREGLDVRVVEVPFENIVGINNCLELSRADSLWQKRKARDLMLSGVTLLKPETVYFSYDTEIEPGVVIEPNVYFGLGVKVQSGAVIRAFSYLEGAVVGQDAQIGPYARLRPGTELAKSVKVGNFCEVKQAKVGESSKINHLSYIGDAEIGAHTNIGAGTITCNYDGFNKYKTVIGDHAFVGSNTALVSPLVIGDGSYVASGSVITENIPMNSMAFGRARQVIKEGYATKFRARLLEKNLSENKQKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.