PharMolix/UniProtQA huggingface dataset:
Protein: UTP25_AJECG
Sequence: MAAPRGKGSRSSNSRGTRGARGKRQRGGRPAFETSRVEKNNDDGSSGSDAEAESPPIDELSSDSDDDYDADGEEKKMDKPYNTLLQLFNTSQDTNGPARKRRKVDHNSKKTEIQVEEQDELHDEADLSEPEITDDDEIEDLADVAAEEVEAGDSGDENDNSSSLSLNIKAISSKGWLSHKSELPGRFRLMFSHPDTGGDTVQLPAPIHGLQSLKLKQKLALHAGDHITKFDSLASGLAPSIFGYHDLLFGARTLSNSARFRDLYCLHVLNHILKTRDRVLKNNSRSQKVPDQDLELRDQGFTRPKVLIILPTRQACVRVMESITKLYHAEQQENKTKFYDTFSAADDKSWENKPDDFRELFGGNDDDMFRLGLKFTRKTIKYFSHFYNSDMILASPLGLRMVMDKEDSKKQDFDFLSSIEVAIIDQADALLMQNWEHVEYVFSHLNLQPKESHGCDFSRVRNWYLDGQAKYVRQTLVFSSFITPEINALFSSQMQNTAGKLKITPTYAGAILDLPLPVPVKQTFSRFDSTSPVNDPENRFKYFTNAVLSPLVRSSTGGRGNPSASGTLIFIPSYLDFVRVRNYLATSSQTENLSFGAISEYTSVRDVARARTHFFSGRHSALLYTERTHHFRRYQIRGVKRVIMYGVPENPVFWAEIVGFLGLDPAGAAEAAEGGVRALFSKWDALKMERIVGTKSRMPRRNTFWSHQPPSFLLLE
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: 5NT3B_CHICK
Sequence: MVPELQKSTVRIQQPERVMGVIRAIKEQGCSKLQVISDFDMTLSRFGCNGRRCPTSHNILDNSHVISEDGKKKLKDLLHHYYPIEIDPNRTLEEKRPLMVEWWTRAHELLSQQKIQKGDIAQIVRESDVMLRDGFNELFDQLHKYSVPMFIFSAGVGDVLEEIIRQANVFYPNVNVVSNYMDFDDSGVLKCFKSPLIHTYNKNNSVLQGTAYFQQLSTRTSIILLGDSMGDLTMADGVPSVENILKIGFLNDKVEEQRGRYLDAYDIVLESDETLDVVNGILRYILMET
What is the function of this protein?
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate.  The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids.  Also has weak activity for CMP.  UMP and purine nucleotides are poor substrates (By similarity).
What are the official names of this protein?
7-methylguanosine phosphate-specific 5'-nucleotidase, 7-methylguanosine nucleotidase, Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidase III-like protein, cN-III-like protein, N(7)-methylguanylate 5'-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the pyrimidine 5'-nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2462_STAA3
Sequence: MSNMNQTIMDAFHFRHATKQFDPQKKVSKEDFETILESGRLSPSSLGLEPWKFVVIQDQALRDELKAHSWGAAKQLDTASHFVLIFARKNVTSRSPYVQHMLRDIKKYEAQTIPAVEQKFDAFQADFHISDNDQALYDWSSKQTYIALGNMMTTAALLGIDSCPMEGFSLDTVTDILANKGILDTEQFGLSVMVAFGYRQQEPPKNKTRQAYEDVIEWVGPKE
What are the official names of this protein?
Putative NAD(P)H nitroreductase SAUSA300_2462.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
Protein: RL16_BIFLO
Sequence: MLIPKRTKYRKQHRPVRSGMSKGGNEINFGDFAIQSLAPAYVTNRQIEAARIAMTRYIKRGGRVWITIFPDRPLTKHPLGARMGSGKGAPEFWIANVRPGRVMFEIGGVSEDIAKEALRRAIDKLPMKCRIIAREGGDI
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: COG2_CHIOP
Sequence: IVGGTEVTPGEIPYQLSFQD
What is the function of this protein?
This enzyme is a serine protease capable of degrading the native triple helix of collagen.
What are the official names of this protein?
Collagenolytic protease 35 kDa 2, Collagenolytic protease 35 kDa II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: PANB_STAAT
Sequence: MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYR1_THEVB
Sequence: MAITAAASRLGTSAFSDAPPVELRANWSEEDLETVIRAVYRQVLGNDYVMASERLVSAESLLRNGKITVREFVRAVAKSELYKEKFLYGNFQTRVIELNYKHLLGRAPYDESEVIFHLDLYENEGFDADIDSYIDSPEYTNSFGDWVVPYYRGFNTQPGQKTVGFNRIFRLYRGYANSDRAQAEGSMSRLARDLATNRANTVVPPSNSDTAFAYYTPSADVPPRACLGGSFGESGRVYRIEVAGIRQPGYPGVRRSSTAFLVPYEQLSAKMQQLQRTGARIISVNPA
What is the function of this protein?
Rod linker protein, associated with phycocyanin.  Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
What are the official names of this protein?
Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=This protein occurs in the rod, it is associated with phycocyanin.
Protein: CLPX_ACIF5
Sequence: MAGKHEGSGEKTLYCSFCGKSQHEVRKLIAGPSVFICDECIELCNDIVKDEILDDHSEAQDKLPKPMEIRKTLDDYVIGQDVAKKVLSVAVYNHYKRLEHGGKDNEVELDKSNILLIGPTGSGKTLLAQTLARLLNVPFAMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQTGIVYIDEIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTRHILFICGGAFAGLEKSVSARLEKGGMGFNAPLKRRDKEATAAMLMQNLEPEDLVRYGLIPEFVGRLPILALLEELDEEALISILTDPKNALVKQYQKLFALEGVTLEFRTEALRAIAKKALARKTGARGLRSILEQILLDTMYELPSMSGVKKVVVDAAVVESGTKPLLVYDDAAKVDMSHPA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LSRC_ECODH
Sequence: MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrC, AI-2 import system permease protein LsrC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFTU_MOUSE
Sequence: MAAATLLRATPRFSGLCASPTPFLQGRLRPLKAPASPFLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLAKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEQRDPELGVKSVQKLLDAVDTYIPVPTRDLDKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRVILPPGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTDVPAMTEEDKNIKWS
What is the function of this protein?
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.  Also plays a role in the regulation of autophagy and innate immunity.  Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway.  In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
What are the official names of this protein?
Elongation factor Tu, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: INS_CHICK
Sequence: MALWIRSLPLLALLVFSGPGTSYAAANQHLCGSHLVEALYLVCGERGFFYSPKARRDVEQPLVSSPLRGEAGVLPFQQEEYEKVKRGIVEQCCHNTCSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSQ_HAEIN
Sequence: MLTLNEHLLNQVLLIAYQSGKHLQQFYQKQVHVELKEDNTPVTEADLFVSQFLTEKLTALFPNVPVLSEENCHISFEERKNWKEYWLIDPLDGTQQFINRTDQFSVLITLVRKNKPVLSVIHAPILSTTYYAMCDFGTFKKQLDQVKKLTKNTTNFDRPLRIAVGATTSQEKVRSILPKDFPCEFVVVGSSSLKSGLVAEGAVDCYVRLGQTGEWDTAGAEVLLGETHGAIFDSHFEPLTYNQRETLINPHFVMVGDQSFDWRSIFQFN
What is the function of this protein?
Converts adenosine-3',5'-bisphosphate (PAP) to AMP.
What are the official names of this protein?
3'(2'),5'-bisphosphate nucleotidase CysQ, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily. CysQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CYMC5_MELCT
Sequence: GVIPCGESCVFIPCISSVVGCTCKNKVCYRD
What is the function of this protein?
Probably participates in a plant defense mechanism (Potential).  Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (By similarity).
What are the official names of this protein?
Cyclotide mech-5.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: SYR_LISMC
Sequence: MNVMQENQIKLIEHIKQGVVQAVGLEEAEVPEILLEVPKDKKHGDYSTNIAMQLARVAKKAPRQIAESIVPELKKDNKLIKEVEIAGPGFINFYLDNAYLTDLVPVILTEDKKYGESDFGKGEKFQIEFVSANPTGDLHLGHARGAAIGDSLANIMKMAGFDVSREYYINDAGNQINNLVLSAEARYFEALGLDSEFPEDGYRGADIISLGKDLAAKYGDKYVHTSEEERRSVFRVDALAFETGKLRADLEEFRVSFDEWFSETSLYEENKVLPALERLRENGYIYEQDGATWLRTTDFEDDKDRVLIKSDGSYTYFLPDIAYHLNKLERGFDVLIDIWGADHHGYIPRMRAAIEALGYSPNQLEVEIIQLVHLFEDGVQVKMSKRTGKSVTMRDLIEEVGLDATRYFFAMRSSDTHMNFDMSLAKSTSNDNPVYYVQYAHARISSILRSGKEQGLEVTKDADMSLLQTEAEYDLLKVLGEFADVVAEAATKRAPHRIVRYLNDLASSFHRFYNSNKVLDMDNLEVTKARLALIKTAQITLRNGLTLLGVSAPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y966_TREPA
Sequence: MIARRMLCARPWGPSCVVCALCGALAALVPAVGAQEQAVPAPGTPAPPAHTASEAVPPAPEPRAEGEQPSPLVPTALPVPGGAVAARAAPGTVGPRLWEQLLQWRVQHGDEHQAPQMAYEIAANNYDIALVKSIVDLRMGTGHIHHNLNGNGAGGMANGTPTLSPYVHLFFPTYQNLSLKADIAIKTNTPSADVTALFGMDLYSKVRRQHQLQVRRARNSMLDAFAAHLRGQHAAREAFLAELDELLSAYSTLLEAQVTEQECTRLVRTMRIQRYQAHSVKLRSATLKHARAERVARRARKTFTALYQDFVRKCGAFEGNDPETFMLHLAQVVPQEPVSSTALLSVENDWEFLKNREDLETQAEARAVDAISYGFNVESGVGSEGKSLKRILANVRMDFPGGGFWLGLNLPYPQWSRVEVKFRLTWDPLSIKYQELSRQTLQLHERLSALKLQDAYEASERKVLGLRHTAESLGWEQEAALTELNILRRSAQTHQKWLERGAIGAHQHARAQHAYLQALITLAKINIKILKFNLETASSFRPVL
What are the official names of this protein?
Uncharacterized protein TP_0966.
What is the protein family that this protein belongs to?
Belongs to the TP096X family.
Protein: GUAA_STRZP
Sequence: MSNISTDLQDVEKIIVLDYGSQYNQLISRRIRDIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: LEUC_BURP0
Sequence: MAQTLYDKLWNSHVVHTEEDGTALLYIDRQLLHEVTSPQAFEGLKLAQRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGRIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTVEYLKGRPFVPTGAEWDQAVEYWKTFRSDEGAQFDRVVELDAAQIVPQVTWGTSPEMVTSIDGRVPDPEREKDPVKRDAMERALAYMALAPNTPIEAIKVDKIFIGSCTNARIEDIRAAAYVVKKLNRRVAPNVRLAMVVPGSGLVKAQAEREGLDKVFTEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAIEGHFVDIRRLG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ARGJ_COREF
Sequence: MAQTGITAPKGFVASATTAGIKPSGKPDMALVVNQGPEYTAAAVFTRNRVIASPVKVSRENVADGQLKAVLYNAGNANACNGTQGDADARESVNTLATKLGLAPEDIGVCSTGLIGELLPMDKVTAGIEALTAEGALGDNGAAAAQAIMTTDTVDKETVVFADGWTVGAMGKGVGMMAPSLATMLVCLTTDASITPAMARIALAKATAVTFETLDIDGSTSTNDTVFLLASGASGVKPTQDELNDAVFAACSDLAEQMQADAEGVTKRVSVTVTGTTTDEMAINAARTIARDNLFKCAMFGSDPNWGRVLAAVGMADADMDPDHIAVYFNDQAVCLDSTGAPGAREVDLSGADIAVRVDLGAGGEGQATVRTTDLSYSYVEINSAYST
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_DINSH
Sequence: MSHNAIRPWRNIYRRKSRQIHVGPVPIGGDAPIAVQTMTNTLTTDIPGTIAQVQAAADAGADIVRVSVPDVDSSRALKEIVRESPVPIVADIHFHYKRGIEAAEAGAACLRINPGNIGDEKRVKEVIKAARDNNCSMRIGVNAGSLEKHLLDKYAEPCPEAMVESALDHIKILQDNDFHEFKISCKASDVFLSAAAYQALADATDAPLHLGITEAGGLMSGTIKSAIGLGNLLWMGIGDTIRVSLSADPVEEIKVGYDILKSLGLRHRGVNVISCPSCARQGFDVIKTVEALEQRLEHIKTPMSLSIIGCVVNGPGEALMTDVGFTGGGAGSGMVYLAGKQSHKMSNEQMIDHIVEQVEKRAAELDAIEAAEAAQDAAREPAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ATPF2_SYNS9
Sequence: MTWLLLAEAGVPEGGLFDLDATLPLMAVQVVLLTFLLNALFFRPVGKVVEDREGFISTSRADAKQKLAQVERLEADLAEQLKGARQAVQSVIVDAEQEVDGLYREALAQAEAEANRTKEESRRGIEAERESARAQLKGKVDQLSTTIIDRLLAA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: GCH1_PHYBL
Sequence: EDHDEMVIVKDVDIFSLCEHHKVPSTGKISIGYIPNRRVVGLSKLARIAEMFSRRLQVQERLTKQVATALMEILQPQGVAVVVECSHLCMVMRG
What is the function of this protein?
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SEPP1_PONAB
Sequence: MWRSLGLALALCLLPLGGTESQDQSSLCKQPPAWSIRDQGPMLNSNGSVTVVALLQASUYLCILQASKLEDLRVKLKKEGYSNISHIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAVKIAYCEKKCGYCSLTTLKDEDFCKSVSLATVDKTVEAPSPHYHHEHHHNHRHQHLGSSELSENQQPGAPDAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPGSEDIQDLQKKLCRKRCINQLLCKLPKDSELAPRSCCCHCRHLIFEKTGSAITUQCKENLPSLCSUQGLRAEENITESCQURLPPPAUQISQQLIPTEASTSURUKNQAKKUEUPSN
What is the function of this protein?
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium.  May supply selenium to tissues such as brain and testis (By similarity).
What are the official names of this protein?
Selenoprotein P, SeP.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein P family.
What are the subcellular locations of this protein?
Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.
Protein: HISZ_SYNE7
Sequence: MVHQPPAGTRDLLPQDVTQKRWIESRLQQVFQQWGYQRIITPTLERLDTLVAGGAVQRSAVIQVQSDEESGLGLRPELTASIARAAVTRLAGSSLPLRLYYLANVFRPAFQGDRLQQRELFQAGVELLGVGGTLADAEVLHVLADALAELGFGQPPLGSWHLVVGEASLTRSLLQPFPKDLREKVRQAIAQLDRVTLESLPLESQLRDRALLLHDLRGQPDQVFAKLQQLTLTPLEQTLRDRLAQLVELYNASAGPQDSPLLLDLSLLRSFDYYTGIVFEVVYETPTGPWVLAQGGRYDRLLDVYDPQAAGQPGIGFSCNIENLQQVLLAANRLPHRPPAIDQLVIPVDSEAYGAALAEAQRLQRQDQLRVELYLDSDRRPEVVQAFAQRRRIGRIVWVSSGSAPQSEAVAVAERATTTC
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSR3_METAC
Sequence: MMNPTNSRDVPLYIYHAGQCDPKKCTGRKMARFELARLYDKISRLPRSAILLDPMAEKALSPADDPKKGIIVLDCSWEEVERVFPELEKLNLEHRALPYMLAGNPVNFGRPFKLNSAEAFAAALYILGYKEQAEKVMSKFNWGHSFLELNREPLDEYATAKNSSEIVEIQSHYI
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LKTA_PASSP
Sequence: MGKLANISTNLKNSLQSGLHKTGQSLNQAGQSLKAGAKKLILYIPKDYEYDSGRGNGLQDLVKAAEDLGIEVQREERNGIATAQNSLSTIQNILGFSERGVVLSAPQLDKLLQKYKISKAPGSSENVAKNLGNAQTLLSGIQSILGSVMAGMDLDEILKNKGSELDLAKAGLELTNSLIENIANSVQTLDTFSEQISQLGTKLQNVKGLGTLGDKLKNFSGFSKAGLGLEVISGLLSGATAALVLADKNASTDRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSNTGPVSALIASTVALAISPLAFAGIADKFNNAKALESYAERFKKLGYEGDSLLAEYQRGTGTIDASVTAVNTALAAISGGVSAAAAGSLVGAPIALLVSGITGIISTILQYSKQAMFEHVANKIHDKIVDWEKKHNGKNYFENGYDSRYLADLQDNMRQLQNLNKELQAERVIRITQQQWDNNIGNLAGISRLGEKVMSGKAYADAFEEGKLIKADTFVQLDSATGVINTSKSDNVKTQHILFRTPLLTPGVENRERIQTGKYEYITKLNINRVDSWKITDGATNSTFDLTNVVQRIGIELDHADNVTKTKETKIIANLGDGNDDVFIGSGTTEVDGGNGLDRVHYSRGDYGALTIDATNESVQGSYTVKRFVETGKALHEVTATQSVLVGSREEKIEYRHSNNTQHAGYYTTDTLKSVEEIIGTSRNDIFKGSKFDDAFHGGDGVDNIDGNAGNDRLFGGKGFDIIDGGDGDDFIDGGQGDDILHGGKGNDILCTVKGGNDSISDSGGNDRLSFADSNLKDLTFEKVNHHLMITNVKKEKVTIQNWFREADYAKTVHNYQATADEKIEEIIGRQGERITSKQIDELIEKGKGKIDQSELERIAESSALLKESKFASNSLNKLVSSAGAFASSNDNRVGLGVPTSLYEHTQSVQFVRAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin kills both BL-3 and pig leukocytes and is not hemolytic.
What are the official names of this protein?
Leukotoxin, PlLkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: RM16_CHOCR
Sequence: MVIIKKTHNSFSLKHRHCNHTLKFGRLGLKILSFSKITENQFNLIERLSLKFLKNLSGNKKLIKIWSLVPFNLTLTKLSSEARMGKGKGAVYSRAFFLRPGSILFEFEGVSKHQLTQISSILRKKTSFRIVEVQLPSK
What are the official names of this protein?
60S ribosomal protein L16, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL16_RHIE6
Sequence: MLQPKRTKYRKQFKGRIKGVAKGGSDLAFGEFGLKAQEPNRVNAREIEAARRAITRYMKRAGRVWIRVFPDVPVTAKPTEVRMGKGKGSVEYWACKVKPGRMMFEIDGVSEEIAREALRLGSAKLSVKTRFVQRIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: P14_ASFWA
Sequence: MADFNSPIQYLKEDSRDRTSIGSLEYDENADTMIPSFAAGLEEFEPIPDFDPTTSTSLYSQLTHNMEKIAEEEDNNFLHDTREFTSLVPDEADNKPEDDEESGAKPKKKKHLFPKLSSHKSK
What is the function of this protein?
Structural protein required for transport of intracellular particles from the assembly sites to the plasma membrane (By similarity).  Binds to both ssDNA and dsDNA (By similarity).  Suppressed the activation of the cGAS/STING pathway by interfering with the recruitment of IRF3 to TBK1, which in turn suppresses IRF3 phosphorylation, decreasing interferon production (By similarity).
What are the official names of this protein?
Structural protein p14.5.
What is the protein family that this protein belongs to?
Belongs to the asfivirus structural protein p14.5 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes at the surface of the intracellular virion.
Protein: RS14Z_LIMRD
Sequence: MAKKSMIAKCNRPAKFSSREYTRCARCGRPHSVYRKFHLCRICLRELAHKGQIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: DAPD_ECODH
Sequence: MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.