PharMolix/UniProtQA huggingface dataset:
Protein: KAD2_BOVIN
Sequence: MAPNVPAAEPVPESPKGVRAVLLGPPGAGKGTQAPKLAKNFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVLELIEKNLETPPCKNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRITGRLIHPQSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNKKALKIRLEAYHTQTTPLVEYYSKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.  Plays a key role in hematopoiesis.
What are the official names of this protein?
Adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: RL36_RICM5
Sequence: MKVVSSLKSLKKRDKDCQIVQRRGKIFVINKKNKRFKAKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LUXC1_PHOLE
Sequence: MIKKIPLIIGGEVQDTSEHDVRELTLNNNTVNVPIITDKDAESITSLKIENKLNINQIVNFLYTVGQKWKSENYSRRLTYIRDLVKFMGYSPEMAKLEANWISMILCSKSALYDIVENDLSSRHIVDEWLPQGDCYVKALPKGKSIHLLAGNVPLSGVTSILRAILTKNECIIKTSSADPFTATALASSFIDTDANHPITRSMSVMYWSHNEDITIPQKIMNCADVVVAWGGNDAIKWATKHSPAHVDILKFGPKKSISIVDNPTDIKAAAIGVAHDICFYDQQACFSTQDIYYMGDKLDVFFDELTKQLNIYKVILPKGDQSFDEKGAFSLTERECLFAKYKVQKGEEQAWLLTQSPAGTFGNQPLSRSAYIHHVNDISEITPYIQNDITQTVSITPWEASFKYRDTLASHGAERIIESGMNNIFRVGGAHDGMRPLQRLVKYISHERPSTYTTKDVAVKIEQTRYLEEDKFLVFVP
What is the function of this protein?
LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
What are the official names of this protein?
Long-chain acyl-protein thioester reductase 1, Acyl-CoA reductase 1.
What is the protein family that this protein belongs to?
Belongs to the LuxC family.
Protein: NU1M_CHOCR
Sequence: MFLLSLLIKIITIILPLLVAVAYMTLAERKVMAAIQRRKGPNIVGVFGLLQPLADGLKLFVKETILPSSANIIIFILAPILTFLLALVSWCVIPLGEGMVYSDINIGVLYILAISSLGVYGIITSGWASNSKYAFLGALRSAAQMVSYEVSIGLILINVLLCSGSLNFTEIVLAQQSIWFVIPLFPIFIMFYISILAETNRAPFDLPEAEAELVAGYNVEYSAMGFALFFLGEYANMILMCSLTTILFFGGWLPPFNLTILYWISPTVWFGLKTTFLLFGFIWIRSSFPRYRYDQLMRLGWKILLPLSLAWVFLISGILLSFNWLP
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL17_STAAE
Sequence: MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PQQD_PSEA7
Sequence: MSLPSLDSVPVLRRGFRFQFEPAQDCHVLLYPEGMVKLNDSAGEILKLVDGRRDVAAIVAALRERFPEVPGIDEDILTFLEVAHAQFWIELQ
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: RS8_ALKOO
Sequence: MTMTDPIADMLTRIRNGNMAKHETIDIPASNMKKEIANILLEEGFIKGFDVIEDGKQGIIRMQLKYGKNKEKVITGIKKISKPGLRVYAKKDEIPRVLGGLGIAIISTSRGIITDKVARKEGVGGEVIAYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ORP1C_ARATH
Sequence: MHPFCCVTTVSDHSPSMPPLPEPQPPLPNYAADFGSARSEPIITRSASQSYNHSGQFNNNLIHSLSFNHHQSDVTDRLGQRVLALPAAVREPPVDVKINDIVGNGIAGILYKWVNYGRGWRPRWFVLQDGVLSYYKIHGPDKIFVSPETEKGSKVIGDESARMISRHNRRGGSSSSCQLRRKPFGEVHLKVSSVRESRSDDKRFSIFTGTKRLHLRAETREDRTTWVEALQAVKDMFPRMSNSELMAPTNNLAMSTEKIRLRLIEEGVSELAIQDCEQIMKSEFSALQSQLVLLKQKQWLLIDTLRQLETEKVDLENTVVDESQRQADNGCSGELRHEKFSEGTATESDDDNERGDAAEEEFDEEENTFFDTRDFLSSSSFKSSGSGFRTSSFSSDEDGFESEDDIDPSIKSIGCNYPRVKRRKNLPDPVEKEKSVSLWSMIKDNIGKDLTKVCLPVYFNEPLSSLQKCFEDLEYSYLLDRAFEYGKRGNSLMRILNVAAFAVSGYASTEGRICKPFNPLLGETYEADYPDKGLRFFSEKVSHHPMVVACHCDGTGWKFWGDSNLRSKFWGRSIQLDPVGVLTLQFDDGEILQWSKVTTSIYNLILGKLYCDHYGTMRIEGSAEYSCKLKFKEQSIIDRNPHQVHGIVQNKSGKTVATMFGKWDESIHFVTGDCSGKGKLSEDMSGAQLLWKRSKPPGNATKYNLTRFAITLNELTPGLKERLPPTDSRLRPDQRYLENGEFEMANTEKLRLEQRQRQARKMQERGWKPRWFMKEKGSESYRYKGGYWEAREDGSWVDCPDIFGHIDSDQQMIE
What is the function of this protein?
May be involved in the transport of sterols.
What are the official names of this protein?
Oxysterol-binding protein-related protein 1C, OSBP-related protein 1C.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: ZCH24_HUMAN
Sequence: MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASPYGSLNNIADGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 24.
Protein: YIDD_SHEB5
Sequence: MAQTQSPLQWLATTLIRGYQVFISPILGPRCRFNPTCSHYAIEAIKVHGTAKGCWFALKRILKCHPLHPGGSDPVPPKNDRCNK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLYA_PYRHO
Sequence: MTYREYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPKQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPVSGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDFESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVVSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLIDKEDPKKVRKDVYYFRLEYQKVYYSFDYGLPMKE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_SHESM
Sequence: MGGQVRVAIVGAGGRMGRTLIESAYHQEHIRLGAAIERPGSSLVGVDAGELAGVGKLNVLVMDSLDYATDDFDVLIDFTAPEASIVHLDWCVRHKKAMVIGTTGFNHAQKEQINAFAEQTPVVMAPNMSVGVNLMWKLLELAAEVMGDYTDIEIIEGHHRHKKDAPSGTALKMGEVIAKTLGRDLEKCAVYGREGITGERDRETIGFATVRAGDLVGEHTAMFADIGERLEITHKASSRMTFANGAMRAAHWLVEQKPGLYDMQQVLGLN
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_MYCUA
Sequence: MSVHGRVAPGQVAGTARQRSEPGTGTWRSRVLGTVLAYLALTKPRVIELLLVTAIPAMLLADRGAVHPLIIANTLIGGMMAAAGANTLNCVADADIDKVMNRTARRPLARAAVPTRSALIFGLALTVISFFWLWLSANLLSGLLALATVAFYVFIYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTGTLAWPALAMFAIIFFWTPPHTWALAMRYKDDYKEAGVPMLPAVATERQVTKQILIYTWLTVLATLALTPAAGWLYAAVAAVAGAWFLTMAHQLYAGVRAGEAVKPLRLFLQSNNYLALVFCALAVDSAIGLPTLLG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOB_PORPU
Sequence: MVQRISLKNKLLPDLVEIQRDSFKWFLLEGLTEVLEFFPNISDPTSRLELQLFGKEYKIKFPRYSVRQAKSRDRTYSAQIYVPAKLTRKDIDLPSKDQNKTIKSLDLSSNHLQFSAEKQIKNKKYKKRLVFIGDLPIMTNRGTFIVSGTERVIINQIIRSPGIYYKQDIDKNGKQIYSASLISNRGSWLKFEIDPKGEIWIRIDKTHKVNAYIFLRAIGLNKNEIQKGLSKYAFLISASQSYSVKELAKEIGKNDIEEVTDEEALLIVYSKLRPNEPATVPVAKQMLYSRFFDPKRYDLGEVGRYKINKKLGLNIPKTFRVLSPQDILSSIDYLINIKDKNSGNLDDIDHLGNRRVRSVGELLQNQFRVGLNRLERIIRERMMICDIDSLSLSNLINPKPLIASVREFFGSSQLSQFMDQTNPVAELTHKRRISALGPGGFNKDRAGFAVRDLHPSHYGRICPIETPEGPNAGLIGSLATCARVNIFGFIETPFYPVHNGQVDYSNNPIYLTADEEDDFRVAPGDVKVNVQNYIEGDIIPVRYRQEFVTTIPNQVDYIAISPIQVISAATSLIPFLEHDDANRALMGSNMQRQAVPLLYPEKPIIGTGLETKIARDSGMVVISRTSGCVNYVSANKIGIQDNNGRTVLYRLKKYYRSNQDTCINQRPIVWVGEKIVVGQTLADGASTDCGEIALGRNILVAYMPWEGYNYEDAFLISERLVYEDVYTSIHIEKYEVECRQTKLGPEEITREIPNVSDHSLKDLDRNGIVVCGSWVEAGDILVGKITPKGEADQLPEGKLLRAIFGEKARDVRDTSLRLPNAAKGRVVNVRVFTRQKGDELPPGTNAMIRVYVAQKRKIQVGDKMAGRHGNKGIISRILPKQDMPYLCDGTPVDIVLNPLGVPSRMNVGQVFECLLGLAGGYLDKRFKIIPFDEMYGAEASRALVNRKLQEASILTKNKWIFNDQHPGKMQVFDGRTGEPFDNPVTIGRAYMLKLVHLVDDKIHARSTGPYSLVTQQPLGGRAQHGGQRLGEMEVWALEAFGAAYTLQELLTVKSDDMQARNEALNAIVKGKPIPKPGTPESFKVLMRELQSLGLDIAVHKLKLFENGQRRTVEVDLMSDSKEDRVARSNYEVLPVDDFEQFLY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CCM1_YEAS1
Sequence: MYMARCGPKNNVLCFPFQLSFLFSKRLINKRFKYTLQTEDEKNMMGSLSKNKIITPEDVEFKLAQLREFSNTLKERIHNTKSVNSDGHQSNSIAPISEDSRNVNVTKISSVPNEEKSKNLSDLIHSSFLEKMDHLVPKVIRERVADDDILAKNLFDRSHSNWAPVIDRLYVSEKRFMDIDSREFSVWLNGTVKYLPFHSILHLDEMLLEQINGDVVKFNTHMYECIFNNLGNLKPTNFNQDGTNDKVILKMKELLERYDKALKITEERINKKEGFPSKVPKMTQAILNNCLKYSTKCSSFHDMDYFITKFRDDYGITPNKQNLTTVIQFYSRKEMTKQAWNTFDTMKFLSTKHFPDICTYNTMLRICEKERNFPKALDLFQEIQDHNIKPTTNTYIMMARVLASSSSNAVVSEGKSDSLRLLGWKYLHELEDKNLYRHKKDDLNLFLAMMALAAFDGDIELSRALYYLFIAKKYKTLCANWKGNILVDQDTIWKSTLMPEMLNYLMLAYARFDPRNLPVLSGYEKGIELRRKFLREFDSSMRLDDTDKLVKFKLPFLPISDLNSEAQVLAESNAIWSFNLENGGTRNTLTSSNEAALEDIKKYRQLLDSFAQEAEDFNEFKFKVMYEVTKMQRESINVNVFNKISLHTYLSIPINLKQQKEFLRRLTFFTFQQHEFEAVIKRLYEGYRNIPSSHTRDQNSISTEAISVSKPETTEDLNLIMHDIWYITCLRHKIMMDTTLYELVMKAAIEFQNEDLAKKVWNDRGKFRTTVPFLKMDQRIRIAKDQKFAHLMVEFFTKQGKYSDAIAIILSSKNRFNWTYSMVRNLHKALEEIEDRNSVEILLDVVNKKSHAKALKWEEQELNM
What is the function of this protein?
RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts.  Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).
What are the official names of this protein?
Mitochondrial group I intron splicing factor CCM1, COB and COX1 mRNA maturation protein 1, Required for respiratory growth protein 2.
What is the protein family that this protein belongs to?
Belongs to the CCM1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IRAD_SHIBS
Sequence: MMRQSLQAVLPEISGNKTSLLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEAR_MOUSE
Sequence: MNALYVTTVPKGYSSLSKCNHNEQDTAYRLWLCTHNHWTAPSGMRLQPLTSLGSKEMKSRWNWGSITCIICFTCVGSQLSMSSSKASNFSGPLQLYQRGIGHITNSYKRPQAPAWPCLSSGTMGRSH
What is the function of this protein?
Dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 v in a highly specific manner (PubMed:16293765).  Also binds the signal peptide of VEGFA (PubMed:16293765).  May play a role in angiogenesis with a significant role in cardiovascular and neural development (PubMed:16293765).
What are the official names of this protein?
Dual endothelin-1/angiotensin II receptor, Dear, Dual endothelin-1/VEGFsp receptor, DEspR protein, FBXW7 antisense RNA 1 homolog.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ENGB_HAEIN
Sequence: MSEIKLNYHKTHFLTSAPNIRSIPEDTGIEIAFAGRSNAGKSTALNALTNQKNLARTSKTPGRTQLINLFEVEPNCKLVDLPGYGYAAVPEQMKIQWQKSLGEYLQKRECLAGLVVLMDIRHPLKDLDQQMIEWAVSANLPVLLLLTKADKLSQSARSKQVKMVREAILPFQGDIQVEAFSAQNKIGIDKLAVKLDFWFSPLFAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: OBG_LEPBL
Sequence: MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGTGGNVIIRPNLSMYTLDKYLSKRKFKAEAGFPGVGDNCSGKKGEDLILFVPLGTQIYDEETGDLLFDFVTDTQEFVVARGGRGGKGNTHFKSSTNQTPRFAQPGEEGEYKFLRLSLKLLADVGIVGLPNAGKSTLISKITDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERVKGILYLFDASSLDIEEDLKMLRNELFTYNPELLNRPYLIVLNKIDIWDDPEFTKDIISKIIHLGKVIAISADKETNLEKLLEAMDEAFFKDEIEKVLKSTKELKSVSLNESDILGSFENSREIKE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3058_RHIE6
Sequence: MTLDDDLNRIAEQEKELSFDAFDLTTAWQLGKLLQELATERCLGVAIDVTLHSMPVFYAALPGVTPDNVNWVRRKRNMVFRYFRSSYASGLKLKKDGKTVEDNGLSGDDYAPHGGSFPINVKGTGCIGAVTVSGLPQRDDHNLVVEALALMLAKDLDTLRLAPL
What are the official names of this protein?
UPF0303 protein RHECIAT_CH0003058.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: KCNA7_MOUSE
Sequence: MLFLPADTGHPTGVAAASGPHVRSPVARAVRAMEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPVRRSRFYDGARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVSFYGLGAAALARLREDEGCAVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDDPGLAPVAAATGPFLARLNGSSPMPGAPPRQPFNDPFFVVETLCICWFSFELLVRLVACPSKAVFFKNVMNLIDFVAILPYFVALGTELARQRGVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDTHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMYSHVDTQPCGTLEGKANGGLVDSEVPELLPPLWPPAGKHMVTEV
What is the function of this protein?
Mediates the voltage-dependent potassium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.  Channels formed by isoform 1 inactivate faster than channels formed by isoform 2.
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 7, Voltage-gated potassium channel subunit Kv1.7.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THI4_ASPOR
Sequence: MSPPAAIYEPTVAATGLKGKVVVSETAPVEGASQTKLLDHFGGKWDEFKFAPIRESQVSRAMTRRYFEDLDKYAESDVVIVGAGSCGLSTAYVLAKARPDLKIAIVEASVSPGGGAWLGGQLFSAMVMRRPAEVFLNELGVPYEEDANPNYVVVKHASLFTSTLMSKVLSFPNVKLFNATAVEDLITRPTENGNPQIAGVVVNWTLVTLHHDDHSCMDPNTINAPVIISTTGHDGPFGAFCAKRLVSMGSVDKLGGMRGLDMNSAEDAIVKNTREVTKGLIIGGMELSEIDGFNRMGPTFGAMVLSGVKAAEEALKVFDERQRECAE
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase, Pyrithiamine resistance protein, Thiazole biosynthetic enzyme.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SNIP1_RAT
Sequence: MKAGKSERERSSRRRHRSGDALATVVVKQERLSPEPVAHRRPDAPAASPPPPAAESGSAGHRGSRARGASRSPAKKKSKSSGRRSKSPRTKRSRSPHYSTVKVKQEREDHPRRGREDRQHRELSEQEHRRARNSERDRHRGHARQRRSSDERPVSGQGRDRDSQILQAQEEERDFNNARRREHRQQNESAGAEAQEVIPRPAGNKNKEVPVKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSELDRKEDEDEEEEEEMVSDSS
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding.  Involved in the microRNA (miRNA) biogenesis.  May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
What are the official names of this protein?
Smad nuclear interacting protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: EIF3I_BOTFB
Sequence: MRPILLQGHERALTQIRYNRDGDIIFSTAKDQHICAWYAHNGERLGTYHGHQGAIWTVDVDPTTTIIASGAADNTVRLWDVKTGKCLKTWDFNTAVKRVEFNEDATQLLAVTEQRMGFLGTIVVLDINLDVNGPQSDDRALTITCAESKATVAGWSYMSKYIIAGHEDGSVSQYDAKTGELLFNTQVHEPDLQVTDLQWSPDRTYFITASKDKTAKLVNARDLEVMKTYVTDTPLNSASITPKKDFVILGGGQAAMDVTTTSARQGKFEARFYHKIFEEEIGRVRGHFGPLNTVAVDPNGKGYASGGEDGYVRVHQFDKGYFDFTYEVERQARQQ
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 39 kDa subunit homolog, eIF-3 39 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_STAA9
Sequence: MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_SHEON
Sequence: MAKTSMKAREAKRAQLVAKFAEKRAALKVIIASPASSDEDRWDAVLKLQALPRDSSASRQRNRCNQTGRPHGFLRKFGLSRIKLREATMRGEVPGLRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: VASP1_VIPAA
Sequence: VIGGDECNINEHPFLVALHTARXXRFYCAGTLINQEWVLTAARCDRXXXXXILGVHSKXXXXXXXXXXXXXXXXXXXXXXTYTRWDKDIMLIRLKRXXXXXXXXXXXXXXXXXXXXXXXXXIMGWGTITTTKVTYPDVPHCADINMFDYSVCQKXXXKLPEKSRTLCAGILQGGIDSCKGISGGPLICNGEIQGIVSYGK
What is the function of this protein?
Snake venom serine protease active on several blood coagulation enzymes.  It completely cleaves fibrinogen Aalpha chain (FGA) after 120 minutes, partially cleaves Bbeta chain (FGB) (overnight) and has no activity on gamma chain.  It does not release fibrinopeptides A and/or B exclusively, since the enzyme does not provoke fibrin polymerisation.  It also degrades fibrin as efficiently as plasmin, and exhibits potent ability to cleave plasminogen and prothrombin, as well as heavy chain of factor X (F10).  In vitro, it cleaves insulin B-chain (at positions His38-Leu39, Ala40-Leu41 and Tyr16-Leu17).
What are the official names of this protein?
Snake venom serine protease VaSP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAY_ECOHS
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.