PharMolix/UniProtQA huggingface dataset:
Protein: NU4LM_LIPVE
Sequence: MSLVHMNILLAFTMSLTGLLMYRSHLMSALLCLEGMMLSLFILMTITILNMHFTLASMTPIILLVFAACEAAVGLALLVKISNTYGTDHVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MASY_MYXXD
Sequence: MSDQAPSVKPPAFGPGVVVKGTWHPDYAEVLTPEALEFVAKLARNFGERRLALLERRKTVQAAWSKGARPHFLPETKAVREGDWTVAPLPADLQDRRVEITGPVDRKMVINALNSGANVFMADFEDANSPTWDNVVRGQINLRDAVRGTISFTAENGKHYALNPKRAVLFVRPRGWHLPERHIEIDGKPISGSLLDFGLFFFHNAREQLARGTGPYFYLPKMQSHLEARLWNDVFHLAQAELGIPRGTIKATVLIETLPAAFEMDEILYELREHSAGLNCGRWDYIFSFIKTLQSDTRVVLPDRGQVTMDKAFLNAYSQLLIQTCHRRNVHAMGGMAAFIPIKGDAAANDAVMDKVRADKLREVKNGHDGTWVAHPGLVEIARDIFDSHMKGPNQLSNKREDVKIGEAELLKVPSGTRTEEGLRHNIRVGIQYTAAWLGGLGCVPLYNLMEDAATAEISRAQVWQWIHHGASLEDGRKVTLTLFRDALGEEMGRLEKEGAKERYGAAHLERARVLFEQLSTAGTFEDFLTLPAYDALEAQR
What are the official names of this protein?
Malate synthase.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDB_ANOFW
Sequence: MNRLAVELPGLSLKNPIMPASGCFGFGREYAKFYDLSVLGAMMIKATTLEARFGNPTPRVAETPSGMLNAIGLQNPGVDYVLAEELPWLAQYDVPIIANVAGSTVEEYVEVAKRISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRAVKEVSDVPVYVKLSPNVTNIVAMAKAIEQAGADGLTMINTLVGMRIDVKTGKPILANGTGGLSGPAIKPIAIRMIYEVSQAVSLPIIGMGGIQSAEDVIEFFYAGASAVAIGTANFIDPYVCPNIIAELPALLDELGFDHISECTGRSWNNGQTVYCGA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPMT_PSEFS
Sequence: MEPKFWQERWARNQIGFHLPEVNPYLLRHWSHLSLADDAKVLVPLCGKSLDLMWLASHGLRVMGVELSEQAVETFFSEQSLTPHITRRGAFTVYQADLLEVWCGDFFALGAEDLADCTALYDRAALIALPPLMRAQYAEHLNTLLRPGCQGLLVTLDYDQTQKAGPPFAVTDDEVAVLFGLKWTLEVLEARDILGESWKFVQDGVTRLDERVYRLVMR
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_VIBC1
Sequence: MSRVCQVTGKRPVTGNNRSHARNATKRRFLPNLQTHRFWVESEKRFVKLRLSAKGMRIIDKKGIDTVLADMRARGENV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: EXFAB_CHICK
Sequence: MRTLALSLALALLCLLHTEAAATVPDRSEVAGKWYIVALASNTDFFLREKGKMKMVMARISFLGEDELEVSYAAPSPKGCRKWETTFKKTSDDGELYYSEEAEKTVEVLDTDYKSYAVIFATRVKDGRTLHMMRLYSRSREVSPTAMAIFRKLARERNYTDEMVAVLPSQEECSVDEV
What is the function of this protein?
Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid.  May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.
What are the official names of this protein?
Extracellular fatty acid-binding protein, Ex-FABP, Protein Ch21, Quiescence-specific protein, p20K.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AAPT2_ARATH
Sequence: MGYIGAHGVAALKKHKYSGVDHSYLAKYVLQPFWNRFVKIFPLWMPPNMITLMGFMFLLTSALLGYIYSPKLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALGCALETMAYGSTAMCGRDTFWFWVISAVPFFGATWEHYFTNTLTLPVVNGPTEGLALIYCGHFFTAIVGAEWWAQPFGKSIPLFSWVPFLNEMQMSRIILFSMIFFAVIPTLAINTSNVYKVVHSRNGSMLLALAMLYPLVTLIAGVLIWDYLSPIDLIRNYPHLVVLGTGLAFGFLVGRMILAHLCDEPKGLKTNMCMSLLYLPFALANALTARLNDGVPLVDEFWVLLGYCIFTLSLYAHFATSVIHEITTALGIYCFRITRKEA
What is the function of this protein?
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively.  Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
What are the official names of this protein?
Choline/ethanolaminephosphotransferase 2, Aminoalcohol phosphotransferase 2, AtAAPT2.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ALAA_MYCTO
Sequence: MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPVHQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRAVVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLARKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITGPKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWTKLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAPDHLRLVTLPWSRDLAAAIERLGNFLVSYRQ
What are the official names of this protein?
Alanine aminotransferase, Alanine transaminase, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_DESHY
Sequence: MGQKVNPKGLRVGIIRDWEGRWFADKNYLELLHEDLKVRKFVKTKLQQAGVPKVEIERAANRVKVSIHAAKPGIVIGRGGTEVENLRKQLEAMTGKQVAVNIVEVKKPELDAQLVAESVAQQLEKRVSFRRAMKQTVQRTMRQGGQGIKISCSGRLGGAEIARTEWYSEGKVPLHTLRADIDYGFAEANTTYGKIGVKVWIYKGEVLPAKKVAQVEGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: BAIP2_RAT
Sequence: MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKAFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAAQLMQQMANSNGSILPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGADSEDYNPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLALPPPDYGTSSRAFPSQTAGTFKQRPYSVAVPAFSQGLDDYGARSVSRNPFANVHLKPTVTNDRSAPLLS
What is the function of this protein?
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins.  Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling.  Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex.  Plays a role in neurite growth.  Acts syngeristically with ENAH to promote filipodia formation.  Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.  Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).
What are the official names of this protein?
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, Insulin receptor tyrosine kinase substrate protein p53.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity).
Protein: PROA_BACC7
Sequence: MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPEESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKIVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPALTSTKYIIRGNGQIRK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SI139_DICDI
Sequence: MTILGSISQIGSMKMGGSKSSFNGSSCGAGFGSNSSSSIISFFNPLLPVVAFISGTVTSITGLVAGALTGTVDGLGKGANTGILLGYTPNI
What are the official names of this protein?
Protein sigN139, SrfA-induced gene N-like protein 139.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: COMP_BOVIN
Sequence: MVLAAARVLLLTLAALGASGQGQMPLGGDLGPQMLRELQETNAALQDVRDLLRQQVKEITFLKNTVMECDACGMQPARTPKLTVRPLSQCSPGFCFPGVACTETANGARCGPCPEGFTGNGSHCADVNECTAHPCFPRVRCINTSPGFRCEACPPGFSGPTHEGVGLAFAKANKQVCTDINECETGQHNCVPNSVCVNTVGSFQCGPCQPGFVGDQASGCRRRPQRFCPDGTPSPCHEKADCVLERDGSRSCVCAVGWAGNGLICGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDQDGIGDACDPDADGDGVLNEKDNCPLVRNPDQRNTDGDKWGDACDNCRSQKNDDQKDTDKDGRGDACDDDIDGDRIRNPVDNCPKVPNSDQKDTDGDGVGDACDNCPQKSNADQRDVDHDFVGDACDSDQDQDGDGHQDSKDNCPTVPNSAQQDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDMDRDGVGDACQGDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVILDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYEAQRLLQA
What is the function of this protein?
Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin.  Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors.  Could play a role in the pathogenesis of osteoarthritis.  Potent suppressor of apoptosis in both primary chondrocytes and transformed cells.  Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity).  Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli.  Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
What are the official names of this protein?
Cartilage oligomeric matrix protein, COMP.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PYRH_SYNAS
Sequence: MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGGNIFRGVEANAKGMDRTSADYMGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFIQRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKADVIMKATKVDGVYDKDPVAYSDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTLVGD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_MYCA1
Sequence: MAMTTEVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAEVDLGNVARRLRKDIFELYGYNAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDNRGRPVRGLPAQVVGGSIADAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVSAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLIWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPDHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKIEGIPDTESAVTPDLLEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: SMBT1_RAT
Sequence: MNGEQQLDADLGSGVEVEEFSWEDYLEETGATTAPYASFKHVDICLQSGFAPGMKLEVALRKDPETYWVATVITACEQLLLLRYEGYGEDRKADFWCDIRRAGLYPIGWCQQNKKTLEAPEGIRDKVSDWSAFLQRTLTGACGPPVALLEGLRNGRNPLDLIAPGSRLECQDFRDSVSTWIVTVVENIGGRLKLQYEGLERHDGFEHWLYYLDPFLHHIGWAAQQGYELQPPLAIRHLKNEADWQEILARVKEEEPLPSYLFKDKQVIRTHEFSINMKLEAVDPWSPFGISPATIAKVFDDKYFLVEIDDLRPEDHARRSFVCHANSPGIFPVQWSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSVSEHQFKENMKLEAVNPLFPEEVSIATVTAVRGSYLWLQLEGSKKPVPEFIVSVESMNIFPLGWCETNGHPLSTPRRARGHKLRKIAVVQPEKQILSSRTVHEGLKNQLNSPHSVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLSCALKKTSKRRKRRKNIFVHKKKRSSASVDNTPVGSPQGSGGEDEDDADDGDDDSLTEGSTSEQQDELHEESEVSEKKSCSPSPTQSEMSTPLPPDTQTDKREAQTSSLSDGENKPPSPKEIRIEVDERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFAFYEQFAN
What is the function of this protein?
Histone-binding protein, which is part of various corepressor complexes.  Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription.  Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1.  Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes.  Part of the SLC complex in germ cells, where it may play a role during spermatogenesis (By similarity).
What are the official names of this protein?
Scm-like with four MBT domains protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: DLTC_STRP4
Sequence: MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVEIENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_LACP3
Sequence: MALSLRACILLLKEHHLLKSAAIQNTEDVDMTGIAYDSRKVSGPTLFFCKGDKFRPIYLSMAKDNGARTYVAEKPYVEGNGLNALIVRNITKAMAILSAAFFDYPQDDLFVIAYTGTKGKTTASYFTEAILNEARPRHIALFSTIDTVVGPEPDQRFKSNLTTPESLDLFRDMREAVENGMTHLVMEVSSQAYLRNRVFGLTYDVGFFLNITPDHIGPNEHPTFANYLHNKLQLLVNARKVVINAETEHFDQVYAAATTTTYPESIYLFASAGFRPKRDDIDIDFRFDSQEADVAESRFTLVPVTEKAAALNIGGHYSLALIGDFNESNATAAIIGAGLAGVDASAAVPGIAKVKIPGRMEHTKVAGHGAVYVDYAHNYASMKALLSFLKHAYKDPRLLVVVGSPGDKGVSRRPGFAKVLTEFATEAFLTTDDPGYEDPANIIEEIDSKIDHSKVKVHKVLDRKKAIAEAISDSGPNDIVVVAGKGADPYQKVRGVNTPWPTDMAVVKQVAKSLQEG
What is the function of this protein?
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramyl-tripeptide synthetase, UDP-MurNAc-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_SORMK
Sequence: MGIKQLFSIIKDEAPAAIKEGDIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMNEAGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATEGLEEAKETGTAEDVEKFSRRTVRVTREHNAECQKLLKLMGIPYIVAPTEAEAQCAVLARAGKVYAAASEDMDTLCFHTPILLRHLTFSEQRKEPIQEIHTDKVLEGLGMDRKQFVDLCILLGCDYLDPIPKVGPSTALKLIREHGTLEEVVEWMKADPKGRYQIPEDWPFEDARALFFEPDVRPADDPLCDFKWEKPDIEGLVQFLAHEKGFSEDRVRSASIKLQKNMQTSQQARIEGFFKVLPKTEEEKKAHKRKLEEQAEQKRKKVKEEKKEKAKLKAKPRGA
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NDHM_PROMP
Sequence: MEKMLLKSTTRHVRIFTADVINNDLVFHPNKLTLDLDPDNEFIWNEDSLKKVNQRFTELVQERAGKSLDDYELRKIGSEIEGLIKYLLQNGLLSYNPECRVMNYSMGLPKTKEVL
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COTL1_HUMAN
Sequence: MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE
What is the function of this protein?
Binds to F-actin in a calcium-independent manner.  Has no direct effect on actin depolymerization.  Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
What are the official names of this protein?
Coactosin-like protein.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Protein: YISX_BACSU
Sequence: MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGEDIERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVGMNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCELEGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV
What are the official names of this protein?
Uncharacterized protein YisX.
Protein: SUOX_MACFA
Sequence: MLLLHRAVVLRLQQACRLKSIPSRIYIQACSTNDSFRPQYPSLTFSGDNSSTRGWKVMGTLLGLGAVLAYQDHRCRAAQESTRIYTKEEVSSHTSPETGIWVALGSEVFDVTEFADLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYKVGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPDTYRLHIVGAPGGQSLSLSLDDLHNFPKYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCDVLAKAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAGVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWDTVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLQAPVPAGQKELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNAWHRVHVFVAP
What is the function of this protein?
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
What are the official names of this protein?
Sulfite oxidase, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: RLME_ANAMM
Sequence: MLAKKHGYRSRSAYKLIDIDCKFKLLQRGRYVLDLGSCPGGWAQVAAERVAEGGKAHVVAVDMAPMERIPNVDFVQCDVEHSPELLRAALQDRKFDVVLSDMAPKSCGHRQVDHANIINLCEMALDLAVEFLRSGGSFVTKILQGEYEQEFRRSLQYYFASVTYFKPKSSRSESSEIYLVGTKFKNPEHPYGNSEDAPSEC
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECA_MYCS2
Sequence: MLQYGAPVITATRETGMDSQVVLALSDTGAGVPLRELALVGLTAAIITYFATGWVRVLAIRFGAVAYPRERDVHVQPTPRMGGLAMYIGVASAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPIGGVGTIVLDQVSSILLTLALTVSIINAMNFVDGLDGLAAGLGLITALAICVFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLGAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMLVPALDTLLAIVRRTRAGRSPLSPDKMHLHHRLLQIGHSHRRAVLLIYLWVGIIAFGAASTIFFDPGQTAMVMGVAIVVAIVVTLIPLLRRGPDGAQEP
What is the function of this protein?
Involved in the biosynthesis of the disaccharide D-N-acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage.  Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc-pyrophosphoryl-decaprenyl (GlcNAc-PP-C50).
What are the official names of this protein?
Decaprenyl-phosphate N-acetylglucosaminephosphotransferase, Decaprenyl-phosphate GlcNAc-1-phosphate transferase, Decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase, UDP-GlcNAc:decaprenyl-phosphate GlcNAc-1-phosphate transferase, UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. WecA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUSD1_BOVIN
Sequence: MEPGSVENLCVVYRSHDFLVVNKHWDVRIDSKAWRETLTLQKQLRHRFPELADPDTYYGFRFCHQLDFSTSGALCVALNKAAAGSAYRCFKDRRVTKAYLALVRGHVQESRMTISYAIGKNSTEGRTHTMCIEGTQGCENPKPSLTELVVLEHGLYAGDPVSKVLLQPLTGRTHQLRVHCSALGHPIVGDLTYGHALGQEDQPFRMMLHAFYLRIPTSAECVEACTPDPFVPSLDACWSPHTLLQPLDELVQVLRAAPDPDPSEGGPGPCSPCTPLPGPGRPPPPPETEVQRASCLQWLSEWTLEPDN
What are the official names of this protein?
RNA pseudouridylate synthase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.