PharMolix/UniProtQA huggingface dataset:
Protein: OFT36_ARATH
Sequence: MERNSSDDEEDHQHLIPQNDTRIRHREDSVSSNATTIGGNQRSAFQIDDILHRVQHRGKISLNKRYVIVFVSLIISIGLLFLLTDPRELFAANFSSFKLDPLSNRVKESELRALYLLRQQQLALLSLWNGTLVNPSLNQSENALGSSVLFEDVKSAVSKQISLNKEIQEVLLSPHRSSNYSGGTDVDSVNFSYNRCRKVDQKLSDRKTVEWKPRSDKFLFAICLSGQMSNHLICLEKHMFFAALLDRVLVIPSSKFDYQYDRVIDIERINTCLGRNVVVAFDQFKEKAKKNHFRIDRFICYFSSPQLCYVDEEHIKKLKGLGISIDGKLEAPWSEDIKKPSKRTVQDVQMKFKSDDDVIAIGDVFYADMEQDWVMQPGGPINHKCKTLIEPSKLILLTAQRFIQTFLGKNFIALHFRRHGFLKFCNAKSPSCFYPIPQAAECIARIVERSNGAVIYLSTDAAESETSLLQSLVVVDGKIVPLVKRPPRNSAEKWDALLYRHGIEDDSQVDAMLDKTICAMSSVFIGASGSTFTEDILRLRKDWGTSSTCDEYLCRGEEPNFIAEDE
What are the official names of this protein?
O-fucosyltransferase 36, O-FucT-36, O-fucosyltransferase family protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase GT106 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NO66_AEDAE
Sequence: MSAVSSIFDTPIPSAAKSSPSGSNKRPLAQNGHHSGEKQSKKSKKASKKQLIDLLVQEHARELSQNDSSASTVSTPKKKKKKNASASDINTSASKNVNAAKKKPKEGLKINLQNSKKKRKNFEVLNSSQQHADDALVETSFNGESLKNNSNHSTPVSKKPKKKNKQMPHPLAGTPNLAIKQEPQTPKANGMQRTSAQDSIVVGREKFAWVIHPTPVEDFMINYWEKKPLLIQRKNPSYYSNLLSRAKIDEMLRQNNIEYTKNIDVTSYREGQRETHNPDGRVLPPDMWSFYEEGCSIRMLNPQTYLPGVYEMNVKLQEFFHCMTGANFYLTPPNSQGFAPHYDDIEAFVLQVEGRKHWKLYSPREPAEMLARVSSPNFTQEEIGTPILEVVLEPGDLLYFPRGIIHQASTVPGHHSLHVTMSVYQKNCWADLLELFFPHALAQAAETHFDLRRGIPLNLHQHFGIVHSDSETPARKQLISHIKSLVDKVFSEDAIDSAVDQLAKRFQHDALPPLISNTEQSTTVYGSSFSHNPDGTVSLRVPFTENSTVRLLRCNVLRLVSEEEKLRIYYHTDNSREYHEYEPNFLEIDQDAALGVELLVKMYPHPVAIRDLPVEDKIEFAKSLWEKGLIVVHGQ
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FK105_ARATH
Sequence: MDSEAEPPQEKKKPNSCPSFLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVERLYLGTHEDVLHVCLQLPDRRLPSWFSLWTKPDQTLTNDIGKKKKSTRNTLLVPIPSSYSPRVPMFIGEIGSELYAISKHNTPSSVMWVRDKTSIYAWRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTDPGAELRVSSIIGMAVSEGKIYVKNSYVKDYVYDPEEDKWDVVASSFMIERKCEIENVLYRFSRQSCSWYDTKHKEWRDIKGLATLNRRRRSSILEVAKYGDKVLILWEIFAKPFYQNKSIWCAVIALEKRKIDEIWGKVKWASIVLTVPRSYVFLRCEVKPV
What are the official names of this protein?
Putative F-box/kelch-repeat protein At4g39756.
Protein: H2B_CAPAN
Sequence: MAPKAAAGKKPAEKKPVEEKKAEEVPAEKKPKAGKKLPKDAGRPDKKKKRAKKSIETYKIYIFKVLKQVHPDIGISSKSMGIMNSFINDIFEKLAQESSRLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B, CaH2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: H2B2_MAIZE
Sequence: MAPKAEKKPAAKKPAEEEPAAEKAPAGKKPKAEKRVPAGKSAGKEGGEGKRGRKKGKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAAEAAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MIAA_STRM5
Sequence: MGIDQRPLAIAVMGPTASGKTATAIALARQLDGEIVSVDSALVYRHLDIGSAKPDAAERAQAPHHLLDLRDPWQTYSAAEFAADASRVVVDIVARGKMPILAGGTGLYFRALLQGLSPMPEADPAMRAALAAEAAERGWAALHAELAQIDPAAATRIHATDPQRIQRALEVYRLTGTPITEWQRRPGVAPLPVRTLKLILAPHDRAVLHQRIEARFDAMLAQGFLDEVRALRAMPEMAAVEAPLDLPAVRAVGYRQAWEYLDGEGDAARFRDKAIFATRQLAKRQLTWLRGELDARWFDPHIDQERLAGAVSTFVAR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: WHY2_ARATH
Sequence: MMKQARSLLSRSLCDQSKSLFEASTLRGFASWSNSSTPGRGFPGKDAAKPSGRLFAPYSIFKGKAALSVEPVLPSFTEIDSGNLRIDRRGSLMMTFMPAIGERKYDWEKKQKFALSPTEVGSLISMGSKDSSEFFHDPSMKSSNAGQVRKSLSVKPHADGSGYFISLSVNNSILKTNDYFVVPVTKAEFAVMKTAFSFALPHIMGWNRLTGHVNTEALPSRNVSHLKTEPQLELEWDK
What is the function of this protein?
Single-stranded DNA-binding protein that associates with mitochondrial DNA and may play a role in the regulation of the gene expression machinery.  Seems also to be required to prevent break-induced DNA rearrangements in the mitochondrial genome.  Can bind to melt double-stranded DNA in vivo.
What are the official names of this protein?
Single-stranded DNA-binding protein WHY2, mitochondrial, Protein WHIRLY 2, AtWHY2.
What is the protein family that this protein belongs to?
Belongs to the Whirly family.
Protein: YCOBA_PROFR
Sequence: MSALLAAHDLVAGFPDRPRVLDTVNLAIGRGTRLALLGANGSGKTTLLSCLAGSLKPTGGAVERDGAPIDWGRKGLREHRRHVQMVLQDPDDQLFSADVSQDVSFGPMNLGLEPDEVHARVREALTLLGADHLAERATHQLSYGERKRVATAGAVAMRPDVLMLDEPTAGLDPLGVHQMRDALDRLTDAGTTIVMATHDVALALDWADEVAIVCDATVHQGAPEALLSDADLVARSHLDTPWPLALAAALGLSARPRNLDEAVAALAPALGEFAATHDAAASVPGSDDTTNTDEETR
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein in cobA 5'region.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ADA2_XENLA
Sequence: MACVSHWLLLLSLASATLSRPLWSERNGLIEMENSIRLGGNIILTPSEATANQKLMTVKGAEFKEAESTGLFPPSMHFFKARPLIQQSHVFSILHQMPKGGALHLHDFAILSVDWLVKNASYMADCYMCLTRDGGVRFLFAKPAPVGMLPPGCSEWILLETYRKKLGDVTEFDKGLIRNLTLLTDSPEPHIPSQDEIWRRFEGAFITASGLICYAPVFKEYFYESLRELYEDNIQYLEMRAMLPPVYELDGTVHDQFWSMAIYRDMANKFVGAHPDFLGAKIIYTVHRHEDLAQVTEAVHLAMKLMEAFPEIMAGFDLVGQEDAGHSLYQLSDALNIPSKLGVKLPYFFHAGETNWQGKDVDENVLDALLLNTTRIGHGYALLKHPVARNLSLELNVPLEICPISNQVLLLVSDLRNHPAAVLMAEGHPLVVSSDDPSIFGAQGISYDFYEMFMGIGGAKADLRTLKKLAENSIKYSALSKEGKEKLTEIWQKKWDKFIKDLAMNWKKEL
What is the function of this protein?
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses.  Stimulates cell proliferation.
What are the official names of this protein?
Adenosine deaminase 2, Cat eye syndrome critical region protein 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: G1092_BACTN
Sequence: MEDSPTQSHVLQLAHPPIPIVRIGIIGLGNRGLLTLQRYLQIEGTEIKALSEIREGNLNKAQLILKEAKHPEATGYTGPGGWRKMCECNDLDLIFICTDWLTHTPMATYAMECGKHVAIEVPAAMNIAECWQLVDTAEKTRRHCIMLENCCYDPFALTTLEMARQGVLGEIMHVEGAYIHDLRSMYFAEESEGGYHNHWGKRYSIEHTGNPYPTHGLGPACQILDIHRNDRMEYLVSMSTHQAGMSEYARKRFGENSPEARQKYKLGDVNTTLIHTAKGKTIMLQYNVSTPRPYSRLQTVCGTLGFAQKYPVPCIALDSHGDTPLEGEALETVLTRYKHPFSATIGEEAHRKGLPNEMNYVMDYRLIYCLRNGLPLDMDVYDAAEWSCITELSEKSVLNGSIPVEIPDFTRGVWKKHKH
What is the function of this protein?
Glycosidase.
What are the official names of this protein?
Glycosyl hydrolase family 109 protein 2.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
Protein: RPOA_PSEPI
Sequence: MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGEIEGTCITRAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPIDFCIDLQIKRDRGYQTELRKNYQDGSYPIDAVSMPVRNVNYSIFSCGNGNEKHEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHAEEEGTSFEENKNRFTPPLFTFQKRLTNLKKNKKGIPLNCIFIDQLELTSRTYNCLKRANIHTLLDLLSKTEEDLLRIDSFRMEDRKHIWDTLEKHLPIDLLKNKLSF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RNH2_HYDCU
Sequence: MTDPQIHLDLMPHGIADEFIVGVDEVGRGPLVGDVVAAAVILPKGCELLLKDSKKLSESKRELIAHQIQQEAIDFCIATASPDEIDSLNILHATMLAMKRAVEGLNNPIKKVLVDGNRCPNVPYECEAIVKGDGKVPVISAASILAKVHRDQQMQVLHEAYPEYGFDAHKGYPTKLHLEKLSQHGLIPGYRRSFKPVKNILQLLEKI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_BACAN
Sequence: MAQVQYYGTGRRKSSVARVRLVSGEGRVIINGRDFENYIPFAALREVVKQPLVATETLGNYDVLVNVNGGGYTGQAGAIRHGISRALLKADPEYRLTLKRAGLLTRDARMKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MT2A_ARATH
Sequence: MSCCGGNCGCGSGCKCGNGCGGCKMYPDLGFSGETTTTETFVLGVAPAMKNQYEASGESNNAENDACKCGSDCKCDPCTCK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable).  Functions as metal chelator of copper (Cu) and zinc (Zn) (PubMed:18287486).  Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves.  The mobilization of Cu from internal sources is important for seed development (PubMed:24635746).
What are the official names of this protein?
Metallothionein-like protein 2A, MT-2A, MT-K, MT-1G.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: HBB_CHLME
Sequence: VHWTAEEKQLITGLWGKVNVADCGAEALARLLIVYPWTQRFFASFGNLSSPTAISGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFTKDFTPDCQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ATPO_SCHPO
Sequence: MNHIFRRSIPITARLPSLGIRSLATATASAHPPVQLYGLDGSYASSLYTAAVKESKLDNVEKALNKLSGVLQQRPEFEQYISSPWLTREDKKILVSSLTQMTGNEPLLKNFYNVLLDNHRLYLLTRIQKQFSTLMRAKRGEIEVKITSATPLDSKILSRLESRIAKSKYGKGKLLVSNKVTPSIIGGLIVEIGDNILDVSVGSRLNNLNKLLSEPI
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
What are the official names of this protein?
ATP synthase subunit 5, mitochondrial, ATP synthase chain 5, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: DHPS_STRP6
Sequence: MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAALDAGVPKNNIWIDPGFGFAKSVQQNMELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLSQLM
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: AROC_SACD2
Sequence: MSGNTFGKLFTVTTFGESHGLALGAIIDGCPPGIELSEEDLQLDLDRRKPGTSRYTTQRKEADQVKILSGVFEGKTTGTPIGLLIENTDQRSKDYGKIKDQFRPAHADYTYMQKYGIRDYRGGGRSSARETAMRVAAGAVAKKVLANLWGIKIRGYLSQLGPIKAELLDWNEVEQNPFFCPDKSKVPEMEAYMQALNKEGNSVGAKITVVAENMIPGLGEPVFDRIDADLAHALMGINAVKGVEIGAGFACVAQKGTEHRDEITPEGFKSNQAGGVLGGISTGQDLIASLALKPTSSLRIPGQSVDIEGNPVEVITTGRHDPCVGIRATPIAEAMMALVILDHALRNRGQNGHVQSGVPIIPGSIPGQIGS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PLPHP_AQUAE
Sequence: MNACERLSRVLERIQKACERAGRGENCAKLLGASKTVPPEVIREFYNCGLKVYGENRVQEFLKKYEALKDLDLEWHFIGRLQTNKVKYLMGKVVLIHSLDRKNLADEIQKRAFKNNIVQDVLIEVNVGGEETKGGVEPENLKELFEYTLELPNVKVLGLMTIPPYLENPEDVRPYFRKLRELRDELQREYNVALPHLSMGMSHDFEVAIEEGATIVRIGTLLFGERKY
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Protein: HIS1_CANGA
Sequence: MDFVNHLNDRLLFAVPKKGRLYEKTKQLLNGSDIKFNRSNRLDIALCTTLPIALIFLPAADIPTFVGEGKCDLGITGLDQVKESGIEEIDLLMDLGFGGCKLQVQVPEKDRKYTDPKQLVGKTIVSSFVKLSRDYFQQLEEEVLGKPVDKLSTKIKYVGGSVEASCALGVGDAIVDLVESGETMRAAGLIDIATVLETSAYLIQARRPQQDKSREELIEVIKSRIQGVLTAQRYVCCSYNTPEGNLKELLKVTPGRRAPTISKLDDDGWVAVNSMIERKRKADIMDELKRKGASDIMVFEISNCRV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_THET2
Sequence: MLRGMKVVLTTGNPGKVRELKEGLAPLGWTLLTLADFALRMPKEEGATFLENALLKAAYVAKATGLPALADDSGLEVYALGGEPGVYSARYGGRATDRERNVYLLERMRHLKGEERKARFVAVLVLAYPDGHAEAYEGSVEGVILEAPRGEGGFGYDPLFYVPEAGKTFAEMGLEEKARYSHRGKALRALLEAYKDGPPPREVSKLE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: HEM3_GEOMG
Sequence: MAPKQLRIGTRASQLALWQANWVKGELEKRYPGMAVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISRGVKFADLPQGARIGTSALRRQAQILKVRPDLQMVVIRGNVETRIRKLTDENLDAVILAAAGLNRLGFADQVSEYLPVELSLPAIGQGALGIECRLDDETIKDTIAFFNHPDTAHAVRAERALLWRCEGGCQVPIAAHGQVSGDTLTLTGFVASVDGTRSVKDTISGPVTECEKLGIALAEKLLADGAHEILAEVYQREVAREKEIPV
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: Y1854_MYCBO
Sequence: MAESDRLLGGYDPNAGYSAHAGAQPQRIPVPSLLRALLSEHLDAGYAAVAAERERAAAPRCWQARAVSWMWQALAATLVAAVFAAAVAQARSVAPGVRAAQQLLVASVRSTQAAATTLAQRRSTLSAKVDDVRRIVLADDAEGQRLLARLDVLSLAAASAPVVGPGLTVTVTDPGASPNLSDVSKQRVSGSQQIILDRDLQLVVNSLWESGAEAISIDGVRIGPNVTIRQAGGAILVDNNPTSSPYTILAVGPPHAMQDVFDRSAGLYRLRLLETSYGVGVSVNVGDGLALPAGATRDVKFAKQIGP
What are the official names of this protein?
UPF0749 protein Mb1854.
What is the protein family that this protein belongs to?
Belongs to the UPF0749 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL18_LARHH
Sequence: MDKKQARLRRARKTRARIAELKMARLSVHRTNCHIYAQIIDETGSRVLAQASTLEAEVKKELANGGNAGAAALIGKRIAEKAKAAGVEKVAFDRSGFQYHGRIKALADAARENGLAF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DEF_BACFR
Sequence: MILPIYVYGQPVLRQVAEDITVDYPNLKELIENMFETMDHADGVGLAAPQIGLPIRVVVINLDVLSEDYPEYKDFRKAYINAHIDVVEGEEVSMEEGCLSLPGIHESVKRGSKIHVRYMDENFVEHNEVVEGFLARVMQHEFDHLDGKMFIDHISPLRKQMIKGKLNTMLKGKARSSYKMKQVK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LUXS_YERPS
Sequence: MPLLDSFTVDHTIMKAPAVRVAKTMKTPHGDEITVFDLRFCVPNKEVMPEKGIHTLEHLFAGFMRDHLNGDGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMADVLKVTDQRKIPELNEYQCGTYHMHSLEEAQSIAKDILDRDVRINHNEELALPKEKLTELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: CINAL_SHESR
Sequence: MMKLEMICTGEEVLSGQIVDTNAAWFASTMMEHGIEIQRRVTVGDRLEDLIAVFQERSLHADVILVNGGLGPTSDDMSAEAMAKAKGESLVENREWRQHLEDWFTRNNREMPVSNLKQAMLPESAVMVDNPVGTACGFRVKLNRAWLFFTPGVPFELKHMVKEQFIPFIREEFDLDAKVALKKLLTIGHGESSLADKIEPLELPEGITIGYRSSMPHIEIKIFARGEKAIALLPRVTGHIKMVLGTAVVAEDKATLAEEIHAKLLNSGLTLSVAESCTGGMITSQLVDFPGSSSYLQHGLVTYSNESKVRVLGVNPATLDDHGAVSIPTVEEMAKGARAILDSDFALATSGIAGPDGGTEEKPVGTVAIALATRSGVYSQMIKLPRRSRDLVRSLSAAVAYDMLRRELLTEAVIVDYQSIGRFSK
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: GH_EHV4
Sequence: MSQPYLKIAILVAATIVSAIPVWTTPVSTSPPQQTKLHYVGNGTWVHNNTFNVTRYDRITMEPVYNNNLSSTTFFVAISERNFRTVNTPLGASVFWILKSALNPPKHQPCIANVPEPGDPRGPCVNSTVSLFFNDNLEPFLMTKNLLEFEVLPDNYITGWTFERSKTVATKGNPVGVVLSPPRTSPDVNNTIRDDGTPKQHLSIIDEHTTFVLDLQNFTKTLTYISPFAAVWPITAFHAGITVMGCDTTQAIAYLGNGFMGLQISSVNNPPLEMIVAPNDVRARIVNRLPPRRRLEPPGPYAGPIYKVYVLSDGNFYLGHGMSKISREVAAYPEESLDYRYHLSLANLDTLAMLAELSSGKSKDVSYYLYRIIARLAVATFSLAEVIRLSDYMLLQEAIDVDINLRLIVPLVMKYAAGGTADSSYTSSDVAMDQFEVAQAQIEKIVADINIENELRKPMYEHRSLLKSVYAYSRKPLPNAVSFANRLITAMYKEAIKDRITWNSTMREVLFFAVGAAAGSHVILTDGPDLGLHAHKDSSMFLSLNRNILLLCTAMCTASHAVSAGVKLEEVMAGLIAGGVQFSLLEVFSPCMASARFDLAEEEHVLDLLSVIPPRLYTDLNTGLEDDGTTIHSYGRSANGILNSRIAYNFDAVRVFTPELASCSTKLPKVLVVLPLASNRSYVITRTAPNIGLTYSLDGVNIAKPIVISYITYGNCQVSRATIRSVYLDHPGHTQSCVYCGSVFMRYMASGAIMDLIYIDDKDVELQLVAGENSTIPAFNPKLYTPSMNALLMFPNGTVTLMSAFASYSAFKIPSTYLWASIGGLLLAILILYVIVKMLCGGVINNDYSLLLNSE
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).