PharMolix/UniProtQA huggingface dataset:
Protein: ACN1_CAEEL
Sequence: MKFHILLLLLVGACLPVFTQEIKPKPELLPADEAPKDPEAVFSEGEPFELTDALDTPKNGSVPVPEPEPKPEPEPEPEPKPEPEPSPTPEPEPAIKFDNIESEDYGDVAETAASTQPDELNTEVIEQLVDTFLNTGSIASNKTNKGPVFANPVAQALVNSSNYWKTDNLQAPGSIKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVRSTSMQAKQFDMASVTDEKVMRQLGYVSFEGMSALAPSRFADYSQAQAALNRDSKDSTICDKDVPPPCALQKIDMDSIFRNEKDASRLQHLWVSYVTAIAKSKPSYNNIITISNEGAKLNGFANGGAMWRSAFDMSSKVHKAEFDLNKQIDKIYSTIQPFYQLLHAYMRRQLAGIYSNPVGLSKDGPIPAHLFGSLDGGDWSAHYEQTKPFEEESETPEAMLSAFNTQNYTTKKMFVTAYRYFKSAGFPHLPKSYWTSSIFARVWSKDMICHPAAALDMRAPNDFRVKACAQLGEPDFEQAHSLLVQTYYQYLYKDQSLLFREQASPVITDAIANAFAHLSTNPHYLYSQKLVPSEHLDIKDSVIINKLYKESLESFTKLPFTIAADNWRYELFDGTVPKNKLNDRWWEIRNKYEGVRSPQPYNTSNLDALIHNSVSQVHSPATRTLISYVLKFQILKALCPEGTILSEGCILSEDTTEKLRETMKLGSSITWLKALEMISGKGELDAQPLLEYYEPLINWLRNTNEIDQVVVGWDGEGTPFTVEEIPKTRQPGDGGNGLPSEDRVAFPGGECVNGQECLLDSHCNGTICVCNDGLYTLEIGNTFNCVPGNPADSGFGDGKGGLVIGLFNNEVTTPEPSAEPEPTAKTTTKMPPRVRAATSPFSLYLTVLLIIYFAL
What is the function of this protein?
Inactive as a metallopeptidase, due to a lack of active site residues (PubMed:14559923).  Required for larval molting, male tail development, and formation of adult alae (PubMed:14559923).  Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production (PubMed:28933985).  Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events (PubMed:28933985).  Might act downstream of the heterochronic protein lin-41 (PubMed:28933985).  Negative regulator of lifespan, heat and oxidative stress response and age-related degenerative changes like reduced pharyngeal pumping and decreased body movements (PubMed:26918946).  Lifespan restriction is dependent on the forkhead-type transcription factor daf-16 (PubMed:26918946).
What are the official names of this protein?
Inactive angiotensin-converting enzyme-related protein, ACE-like non-metallopeptidase protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
Protein: RS3_CHESB
Sequence: MGQKVNPIGLRLGINRTWDSRWFANTNEYGQLLHEDLKIRTYIENELKQAAISKVVIERPHKKCRVTIHSARPGLIIGKKGADIEKLRRKITQMTNAETHLNIVEVRKPEIDARLIAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCTGRLGGAEIARIEWYREGRVPLHTLRADIDYGTAEAKTAYGVCGVKVWVFKGEILEHDPMASERRAVEGAGDGGGQRRRENA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CYOE_YERPA
Sequence: MMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYP_BORBZ
Sequence: MSDFIASKEDDYSKWYLDIVQKAKLADYSPVKGCMVIMPYGYSIWSKIQSILDKKFKETGHENAYFPMLIPYSFLEREKDHIDGFSPEFAIIKDAGGESLAEPLVLRPTSETIIWNMYSKWIKSYRDLPLKINQWANVVRWEKRTRPFLRTTEFLWQEGHTAHATEEEALEETLLILDVYKRFIEDYLAIPVFCGKKSEKEKFAGAVSTYSIEALMQDKKALQAATSHYLGLNFAKAFDVKFQDKDGKMRHVFASSWGVSTRLIGALIMVHSDEKGLVLPPRIAPIEIIVIPIFKKEDEINKKILDYCDCVVDALKKAGFRVEIDKDVRSSPGFRFSSAEFKGIPIRLEVGINDVLLNSVTISRRDKDRKFKYQISLDSLVSKVKVELDLMQKDLFQRALNFRILNTKEIFRSSKDSYETFKAYVNDYSGFVLSCWCGSLNCENIIKNETKATIRCIPDDFKARDLTGMTCIYCSSKAKYFVLFAKSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_NITHX
Sequence: MADGTAANSSRRIFLIATEESGDRLGSSLMKVLRRRLDDAVRFEGVGGRSMAREGLVSLFPIEDLSIMGFAAVVKQLPMILRRIRETADAVIAAEPDMLVIIDSPDFTHRVARRVRARRPALPIVDYVSPSVWAWRPGRARAMRRYVDHVLALLPFEPEEYRRLAGPPCTYVGHPLIEQVGMLRPDAQERQRRDAPPPALLVLPGSRRSEIDHHMAVFGETLRTLQLDAGEMDVVLLTMPHLIEKVKAAVASWPLQPRIVVGEQGKQAAFRVARAALTKSGTVTLELALAGVPMVTAYRGGAVEAWIAQRVIRTSSVILANLVIGENVIPEFLQENCTPENLAPALREILTDSPLRRRQLKAFAKLDAIMATGQHSPSERAADIVLETMHASRGPE
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: ORC5_MOUSE
Sequence: MSHLESMVLCREAQVSTLQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHAFVNCVECFTSRLLLEQILNKLSHLNSSDAGCSTEMTCETFNDFVQLFKQVTSAEHLKDQTVYIVLDKAEYLRDMEANLLPGLLRLQELTDRNVTVIFLSEIIWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEAGERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDNTDPGQLKGLSAYTHMELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTIVGHEDQLNGPKYKCTVSLDFIRAIARMVNFDIIKYLYDFL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
What are the official names of this protein?
Origin recognition complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the ORC5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TMCAL_STRP6
Sequence: MTVTGIIAEFNPFHNGHKYLLETAEGLKIIAMSGNFMQRGEPALIDKWIRSEMALKNGADIVVELPFFVSVQSADYFAQGAIDILCQLGIQQLAFGTEDVIDYQKLIKVYEKKSKQMTAYLSTLEDTLSYPQKTQKMWEIFAGVKFSGQTPNHILGLSYAKASAGKHIQLCPIKRQGAAYHSKDKNHLLASASAIRQHLNDWDFISHSVPNAGLLINNPHMSWDHYFSFLKYQILNHSDLTSIFQVNDELASRIKKAIKVSQNIDHLVDTVATKRYTKARVRRILTYILVNAKEPTLPKGIHILGFTSKGQAHLKKLKKSRPLITRIGAETWDEMTQKADSIYQLGHQDIPEQSFGRIPIIIKNERLN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_BURCJ
Sequence: MSGLTHFDAAGHAHMVDVGGKQETQRIAIARGTIRMLPATFALIRDGKAKKGDVLGVARIAAIQGAKRTADLIPLCHPLALTRVAVDFELDDALPGVHCVVQVETFGRTGVEMEALTAVQVGLLTVYDMCKAVDRGMVITDVSVREKRGGKSGDWKAEDVAG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: LCNL1_HUMAN
Sequence: MVGVVSDDQDFLDSKDTMKMAVVLVTPLGNGDLALKFGYPTPHGGCQKMDTTFTEGAVPGQFSNPAMALSDIRVAFSDYQHFALLYLEMRKGGLRNQWLQLYGGRAAGRRPRHPRFGSGMSPLCLHQPFLHAEGGTAGSWCLWPRVPAPPCPSLPLFAPPAPSL
What are the official names of this protein?
Lipocalin-like 1 protein.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: CYA2_RHIME
Sequence: MRWRFSTLEIILLLLVVAGSGMAYAWVVYGGGGLIGATYALFMCMPILAFERHIIFRRLYRRIHGSPTPAFLLSSLAVYFIFVNVGYAAAGLLLHVAGVMRESRTDAMLPSLNVLVYALATSGPIIFVLRVRELLGRDVFLSLLTGRYRKPVQEERVFLFIDLAGSTSLAERFGDLRMQEYLGKLFAAMADPVLRYGGSIDDYVGDAAVITWPYDRAVADAACIRCVFDILEQIEADAHRWQKDYGEVPRLRAALHGGTIVAAEIGVDKHKITYFGDTVNTTARLEGLCRTLNRQVLISADLLRRLRPPVFVRAEDLGEHEVKGRGQKLAVLSLTAGSLSGDGATEPAGETVRSPAAEAFTSL
What is the function of this protein?
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
What are the official names of this protein?
Adenylate cyclase 2, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
Protein: NIFH2_RHOCA
Sequence: MTRKIAIYGKGGIGKSTTTQNTAAALAFFHEKNVFIHGCDPKADSTRLILGGLPQQTVMDTLRIEGAERVTVDKVVKTGFKDIRCVESGGPEPGVGCAGRGVITAIDLMEENEAYSEDLDFLFFDVLGDVVCGGFAMPIRDGKAEEVYIVASGEMMAIYAANNICKGLAKYARQSGVRLGGIICNSRNVDGEKEFLEEFTKAIGTKMIHFVPRDNIVQKAEFNKQTVTEFQPEANQAQEYRELGRKIIENEDFVIPKPLAMDELEAMVVKYGLMD
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein (component 2) and a component 1 which is either a molybdenum-iron protein, a vanadium-iron, or an iron-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 2, Nitrogenase Fe protein 2, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: MNMA_METS4
Sequence: MNSLDLPKAPQDTRVVVAMSGGVDSSVVAGLLRRQGYDVVGITLQLYDHGAATHRRGACCAGQDIHDARRAAETLGIPHYVLDYEDRFREAVIDRFAESYIHGETPIPCVECNRSIKFRDLLATALDLGADALATGHYVASRARPGGGRALYRALDPARDQSYFLYATTPEQLDVLRFPLGELPKDETRRLAREFGLAVADKPDSQDICFVPQGRYQDVIARLRPDAARPGEIVHLDGRTLGRHEGIIGFTVGQRRGLGLATGEPLYVVRLDPETARVVVGPREALATSVIRIAETNWLGDEPLADLDGMPVAVRVRSTREPRPAALRWNRALACAEVVLETPEDGVSPGQACAIYADDGPRARVLGGGTIQKVEAARREAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_STAHJ
Sequence: MLSDYKEKIKNKLSVVPFEPGCYLMKDRNDQVIYVGKAKRLRNRLRSYFTGAHDAKTTRLVGEIRNFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKHPKLIVTRTVKKGTGKYFGPYPNAYSAQETKKLLDRIYPFRKCDKMPDKLCLYYHIGQCMGPCVYDVDQQVYAQMTREISDFLNGEDKTILKNLEDRMMDASEKLDFERAKEYRDLIQHIHNLTKKQKIMSSDNTIRDVFGYNVSKGWMCIQVFFIRQGNLIQRDATMIPLQQQSEEEEFYTFIGQFYSLNQHILPKEVHVPKNLDKDMIQSVVDTKIVQPARGAKKEMVDLANHNAEVALENKFELIARDESRTIKAIEELGERMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKADKKGYRKYKIKTVDGPDDYKSMREVVRRRYTRVLNEGLPLPDLIIVDGGKGHMSGVLDVLENELGLDIPVAGLRKNDKHQTSELLYGPNAEVVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLQSVLDTVDGIGSKRKTSLLRTFGSIKKMKEASVVDLKKAGLPEKVALNLQQALSND
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_WIGBR
Sequence: MSKLLLGVNVDHVASLRNVRGGKFPDPVQLAILAEIAGADSITTHLREDNRHINEKDVICIKKSIQSRLNLEISTKKEMINKAINILPYSCCLVPENRQEITTESGIDVIKNKKYLKKVICKLKSLGIKVSLFVDPIKNQILSSSEINADCIEINTGKYSEQDKKENKEEINLIKLCAKYANKLGLEVHAGHGLNYFNVRSIVNIKEIKELNIGHSIISRSLIVGMQNAVKEMKDIIYSEKIKWQ
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFG_TRIEI
Sequence: MSRIVTYSPAYTIVPTYECFNNCSYCNFRSDPGKSSWLSLSEAEKQLLSLKNKGTIEILTLSGEVHPNSKYRKAWFQLIYKLCQLALSLGFLPHTNVGILTRSEMEELKQVNVSMGLMLEQITPKLLKIVHKNSPSKIPHLRLQQLEWAGELRIPFTTGLLLGIGETVTDWKDTLEAISNIHQKWGHIQEVIIQPYSPGSENKWVSDGFNVNLLPEVIAIANEVLPSNITLQIPPNLVKKPEILLACLENGARDLGGIGPFDEINPDYPHPHYQALIKVLESRGWQLTKRLPVYSKYDDWLPINLKNIVSEWRIKLSIY
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
What are the official names of this protein?
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, FO synthase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofG family.
Protein: APOA1_CHILA
Sequence: MKAVVLAVAVLFLTGSQARHFWQRDEPQTPWDRVKDFATVYVDAIKESGRDYVAQLETSVLGKHLNLKLLDNWDTLSTTFSKLRADLGPVTQEFWDNLEKDTEWLRQEMNKDLQEVKQKVQPYLDNFHKKMQEEMERYREKVGPLGTELREGARQKLQELQEKLTPLGEDLRDRAREHVDTLRTQLAPYSDDMRQRLTQRLEALRDSTTFADYQAKASEHLKTFSEKAKPALEDLRQGLLPVLESLKASILSSIDQATKQLTAQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility.
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: YT13_CAEEL
Sequence: MQVRWAPSDGSLGDYTYQQDMSSSDKLSADDVLNTLDKSNRHILTCILVCGLAWSPLAFTGLCPSFVVKASENSSFIGVADEFDLTGDASWLAESTTTFYMVGNMIGGMFIPPLADHYGRLPVFVATVLLMAVGGMISAFSTSIMMFCIMRMIHGIFYTAAGLAGWVLGYENTPLRLRFFTSVYFGVMWVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIRGPKGDISASDIVEDRDENGSSFKTLCREMWKHKMFIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLSLIAVSGGLLTLILPETLNTKLPSTIAETASRRQLIDDKSDSSSN
What are the official names of this protein?
Putative transporter B0252.3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TF2B_HUMAN
Sequence: MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL
What is the function of this protein?
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II).  Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682).  Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312).  Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352).  Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171).  Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841).  Modulates transcription start site selection (PubMed:10318856).  Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).
What are the official names of this protein?
Transcription initiation factor IIB, General transcription factor TFIIB, S300-II.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171).
Protein: G3P_METS5
Sequence: MIKVAVNGYGTIGKRVASAILAQPDMTLVGVSKTSPNYEAYQAQKMGINLYVTKESLKEFEEAGIKVKGVLEDMIKEADVVVDATPNGVGAQYKQVYSSMGKRALFQGGEKANVADVSFSALCNYDEAVDKRYVRVVSCNTTGLLRTLCTLNRVSKIAKVRGTIVRRAADPKEVKKGPINSLVPDPASIPSHHAKDVNTVLKDLDIVTMAVVAPTTLMHVHLLDVTVSSPVTKEDVLSVLSSTPRILLASGKSKVSSTAEIVEVARDMGRPRNDLYELVVFEDSVSVRGNEVFLMYAVHQESIVVPENVDAIRAVSGFADGRKSIEMTNASMGIGKGYLV
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM22_RAT
Sequence: MAAALLRELGALWVPNLRIWTTQMLRVLPQSCIHTSTSLDISRRWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLHIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPRPEAPRTAVDHAKEYIQQLRSRTIIHTL
What are the official names of this protein?
39S ribosomal protein L22, mitochondrial, L22mt, MRP-L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KNOX5_MAIZE
Sequence: ELKEMLLKKYSGCLSRLRSEFLKKRKKGKLPKDARSALMDWWNTHYRWPYPTEEDKVRLAAMTGLDPKQINNWFINQRKRHWKPS
What is the function of this protein?
Probably binds to the DNA sequence 5'-TGAC-3'.
What are the official names of this protein?
Homeobox protein knotted-1-like 5.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVC_MYCSS
Sequence: MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSREKVTEQGLEVDTPAEVAKWADVIMLLAPDTAQAEIFTNDIEPNLEDGNALFFGHGLNIHFGLIKPPANVTVGMVAPKGPGHLVRRQFVDGKGVPCLIAIDQDPKGEGQALALSYAAAIGGARAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDADTKERMRAILKDIQDGTFVKRLVANVEGGNKELEDLRKKNAEHPIEVTGKKLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: YB7A_SCHPO
Sequence: MRRSGTSLSRDLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKKPILEKVVEKVLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESEKKVREVFEEAKSLAPCLMFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKTDGKPVLVIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLSEASSRVVNTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVLGRDERCSNFSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSASTNDAD
What are the official names of this protein?
Uncharacterized AAA domain-containing protein C16E9.10c.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YM12_PARTE
Sequence: MKSLFYFFERINFLTADFLLKKIRIGADNLKDVSSLDLFFVHMHHRGVAVHNIFLFLLTYVPFFKRAVLGCYLKKKLFIDHDLKNKNYFKMKRANALFFKGDFLTSNNFLRASTTFYNSFFFFLIRNHVITKTTLNAIYFSKGSFKPAETSYYFNAYVLHFFKKNKVNDFIVFLNENKIKDYWAYLTTIYASPEAQNLKLIDPVGSLIEQSNSYADRLPTRRTLRKPAPTQSSMSRLCILLFSLTTPPLKKLRPPLSLRLHSCYP
What are the official names of this protein?
Uncharacterized mitochondrial protein ORF12.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CP512_ARATH
Sequence: MDWDYYTLLKTSVAIIIVFVVAKLITSSKSKKKTSVVPLPPVLQAWPPFIGSLIRFMKGPIVLLREEYPKLGSVFTVKLLHKNITFLIGPEVSSHFFNAYESELSQKEIYKFNVPTFGPGVVFDVDYPVRMEQFRFFSSALKVNN
What are the official names of this protein?
Putative sterol 14-demethylase-like protein, Cytochrome P450 51A1, Cytochrome P450 51G2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NADD_FLAJ1
Sequence: MKIGLYFGTYNPIHVGHLIIANHMAEFADLDQIWMVVTPHNPLKKKSTLLDDQQRLQMVYLATEDYTKIKPSDIEFKLPQPSYTVITLEHLKEKYPNHEFSLIMGEDNLKTLHKWRNYEVILENHDIYVYPRISDEPENVELKSHPKIHVIDAPIVEISSTFIRNSIKEGKNIQPLLPPKVWEYIDHNNFYKK
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: 1A1D_ACIAC
Sequence: MNLQKFPRHALTFGPTPIHPLKRLSAHLGGKVELYAKREDCNSGLAFGGNKTRKLEYLIPEAIEGGYDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQENWVNYSDAVYDRVGNIEMSRIMGADVRLDAAGFDIGIRPSWEQAMEDVRRAGGKPFPIPAGCSEHPRGGLGFVAFAEEVRQQEEELGFQFDYIVVCSVTGSTQAGMVVGFAADGRADRVIGIDASAKPEQTREQILRIARNTAELVELGREITDADVVLDTRYGGPEYGLPNEGTLEAIRLCARQEGMLTDPVYEGKSMHGMIDMVRNGEFPAGSRVLYAHLGGVPALNAYSFLFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.