PharMolix/UniProtQA huggingface dataset:
Protein: PYRG_HALSA
Sequence: MPTETEYDPSLGSKFVFVTGGVMSGLGKGITAASLGRLLSNAGFDVTAVKIDPYLNVDAGTMNPYQHGEVYVLDDGGEVDLDLGNYERFLDEDMTSDHNVTTGKVYQDVIERERSGDYLGKTVQIIPHVTDDIKRRVREAAEGSDVCLVEVGGTVGDIEGMPFLEALRQFSHEQDDEDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCEDRLDPDVREKIALFCDVPMDAVFSNPDVEDIYHVPLTVEEEGLDQYVMEQFDMVEDALPAAQRSTEWRDLVTRERTGEVDIALVGKYALEDAYMSIHEALKHASLEAGVEVNVLWVDSEKMHDHHERRIADADGIVVAGGFGSRGTAGKIDAIQHAREHDVPFLGLCLGFQLAVVEYARNVLGMTGAHSAEIDEDTEYPVIDLLPEQYDLEDLGGTMRLGAHETAIEPGTLAHDLYGATSCTERHRHRYEVNPEYIDDLTADGLTFSGEAGNRMEIVEHDDHPFFFGTQFHPEYRSRPTRASPPFVGLLDAVLERADVAPAGSDADVEVTN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y2135_DICDI
Sequence: MFKFSIPLLLFIFLFFSCINSITHIRVGAFYPPPAHLQPQSGFIWEFLGTRNPDKSNEKLPERILSGSSGSCSSCSISSSNGSSSRSSKQ
What are the official names of this protein?
Putative uncharacterized protein DDB_G0293808.
Protein: AROK_CERS4
Sequence: MKVGAEVRRRGNREDGRQVMARLKKTVVMVGMMGAGKTAVGSALARGLNVPFLDSDEEIERAANRTIAEIFARDGEPFFREKESQVLARLLRGSPCVLSTGGGAFMAEGNRRMIREQGVSVWLKADLDVLWHRVRHKATRPLLRTPNPRETLRALLEARDPVYAQADLAVESGEGTVEQMAVRVREALATRPDVLETDE
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARBH_ASFWA
Sequence: MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSAQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDIYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI
What is the function of this protein?
Suppresses apoptosis in host cell to promote the viral replication (By similarity).  Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family (By similarity).  Inhibits autophagy by interacting with host Beclin 1 (BECN1) (By similarity).
What are the official names of this protein?
Apoptosis regulator Bcl-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Host mitochondrion. Host endoplasmic reticulum.
Protein: Y1261_RUBXD
Sequence: MVQEMLGGTRITYLGHATFRLTTPGGENILIDPFLADNPQTPEELKQVGDLDTILVTHGHFDHFADAIPVARQTGATVVANFEISSYVQSQGIENSMPLNKGGTARVGGVKVTGTNAFHASSIQTEDGSTIYGGEPMGFVVEFESGFKVYHAGDTAVFGDMRLIGELYGPDLALLPIGDRVVMSPFEAAHAARLLGVRHVVPMHYGTFPFLPGTPEEFERHARELGLELEIHVMKPGEELGS
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Rxyl_1261.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: ABCG2_DICDI
Sequence: MAPPEIGNDEIPLQEFGQKSFAADNTIGGMQSISYDNSGAPMGLYKEKKGMYVTARNLSMSIGTEKKGDKRNILSDLNFFLKPGSMVLILGSPGCGKTSVMKALANQLHSETVSGSLLFNGKAANKSTHHRDVAYVVQGDHHMAPFTVRETFKFSADLQMSEGTSEEEKNARVDYILKTLDLTRQQDTVVGNEFLRGVSGGQKKRVTIGVEMVKDAGLFLMDEPSTGLDSTTTLELMKHFRELSNVNQVSSLVALLQPGVEVTKLFDFLMIMNAGHMVYFGPMSDAISYFEGLGFKLPKHHNPAEFFQEIVDEPELYFEGEGEPPLRGAEEFANAYKNSAMFQSIVNDLDNTQPDLTFCKDSSHLPKYPTPLSYQIRLASIRAFKMLISSQVAVRMRIIKSIVMGLILGSLFYGLDLNQTDGNNRSGLIFFSLLFIVFSGMGAIAILFEQREVFYIQKDGKYYKTFAFFLSLIFSEIPIALLETVVFCVLVYWMCGLQANAEKFIYFLLMNFVGDLAFQSFFKMVSAFAPNATLASVIAPAALAPFILFSGFMAPKRSIGGWWIWIYWISPIKYAFEGLMSNEHHGLIYSCDDSETIPPRNTPNFELPYPRGSGNSSICQITRGDQFLDQLGMPQNNWFKWIDLLIVFAFGALFSFGMYFFLKNVHVDHRASDPKNDKRSKKASKRSKKIKDSKVDIKENRMVKAQKEIPIGCYMQWKDLVYEVDVKKDGKNQRLRLLNEINGYVKPGMLLALMGPSGAGKSTLLDVLANRKTGGHTKGQILINGQERTKYFTRLSAYVEQFDVLPPTQTVKEAILFSAKTRLPSDMPNEEKIKFVENIIETLNLLKIQNKQIGHGEEGLSLSQRKRVNIGVELASDPQLLFLDEPTSGLDSSAALKVMNLIKKIASSGRSIICTIHQPSTSIFKQFDHLLLLKRGGETVYFGPTGDKSADLLGYFENHGLICDPLKNPADFILDVTDDVIETTLDGKPHQFHPVQQYKESQLNSDLLAKIDAGVMPVGTPVPEFHGVYSSSYQTQFVELGKRSWLAQVRRVQNIRTRLMRSLFLGVVLGTLFVRMEETQENIYNRVSILFFSLMFGGMSGMSSIPIVNMERGVFYREQASGMYSIPIYLFTFIVTDLPWVFLSAIIYTVPMYFISGLRLDPNGAPFFYHSFISFTTYFNFSMLAMVFATVLPTDEIAHALGGVALSISSLFAGFMIPPASIAKGWHWFYQLDPTTYPLAIVMINEFQDLEFHCTSSESVTIPNVLTVNGTYIDVGPICPITNGNQILQRYEMKPEDKYKFLAVIFGYSVFFFICIFIALKFIRHQTK
What is the function of this protein?
Required for endocytosis and endosomal pH regulation.
What are the official names of this protein?
ABC transporter G family member 2, ABC transporter ABCG.2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Note=Associated with the endosome/lysosome system.
Protein: HSCB_RICRO
Sequence: MQNYFQLLGLPQEYNINLKILEKQYFAMQVKYHPDKAKTLQEKEQNLITAAELNNAYSTLKDALKRAEYMLLLQNINLNDEKTRSLLSPLELSIFWDEMEIIENTILFSDLEKIKDKYELMKKLEIDALKQAFEEQNLSDATIKTSKLKYIGTLLHKLQEKIKSCK
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: SYC_PYRAB
Sequence: MGIKVYNTLTRKKEELKPLRDGEVRMYVCGPTVYDYPHLGHARTYIAFDVIRRYLEHRGFTVLMVMNFTDIDDKIIKRAQETGEDPGKLAERFIKVFLEDMNALKVKPADIYPRVTEHIDDIIEFIKKLKEKGYAYEGSDGVYFEVQKFKDYGKLSGVKIEELRKGARVEPGEGKKNPEDFALWKKAKPGEPKWDSPWGEGRPGWHIECSVMSSKYLGESFDIHGGGNDLIFPHHENEIAQSEACFGHEWVRYWLHTGFVMVKGEKMSKSLGNFVTVRELLQRYSPEVIRLFVLQKHYRSPLDYTEEGLQHAKNNLERLYNTLENIRIAMRNAELSYKWSEKDFEAYEAIREARKKFYDAMDDDFNTAEALKAVFEVSNAINKYILEVDKPKESILRKALEFFKVVSEVFGIFEDYFKEEKKGEEEKLIELLVEVRKQLRKEKRFDLADKIREELRKLGIQLEDKGQETVWKRVKVS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEAB_ECOLI
Sequence: MTEPHVAVLSQVQQFLDRQHGLYIDGRPGPAQSEKRLAIFDPATGQEIASTADANEADVDNAVMSAWRAFVSRRWAGRLPAERERILLRFADLVEQHSEELAQLETLEQGKSIAISRAFEVGCTLNWMRYTAGLTTKIAGKTLDLSIPLPQGARYQAWTRKEPVGVVAGIVPWNFPLMIGMWKVMPALAAGCSIVIKPSETTPLTMLRVAELASEAGIPDGVFNVVTGSGAVCGAALTSHPHVAKISFTGSTATGKGIARTAADHLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYIEAPLFDTLVSGFEQAVKSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRGSNGPAGEGYYVAPTLVVNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTASVWTQNLSQALEYSDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKSVCVRY
What is the function of this protein?
Acts almost equally well on phenylacetaldehyde, 4-hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde.
What are the official names of this protein?
Phenylacetaldehyde dehydrogenase, PAD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ATPF_MANSM
Sequence: MNLNATLIGQLIAFALFTWFCVKFVWPPIIKAIEERQSSIANALASAEKAKQDQADSQAAVEQEILAAKEEAQKIIDLANKRRNDILEEVKTEAENLKATIIAQGHAEVEAERKRVQEELRVKVASLAIAGAEKIVGRTVDEAANNDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y545_STRPZ
Sequence: MSDKHINLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALVPKFLELIEQTNENRRVALVVDMRSRLFFKEINSTLDSIESNPSIDFRILFLDATDGELVSRYKETRRSHPLAADGRVLDGIRLERELLSPLKSMSQHVVDTTKLTPRQLRKTISDQFSEGSNQASFRIEVMSFGFKYGLPLDADLVFDVRFLPNPYYQVELREKTGLDEDVFNYVMSHPESEVFYKHLLNLIVPILPAYQKEGKSVLTVAIGCTGGQHRSVAFAHCLAESLATDWSVNESHRDQNRRKETVNRS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Spy49_0545.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PYRG_THEVB
Sequence: MTKYVFVTGGVVSSIGKGIVAASLGRLLKSRQYSVSILKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTDTPMSRLNSVTTGSIYQAVINKERRGDYMGGTVQVIPHITNEIKERILRVAKDKNPDVVIIEIGGTVGDIESLPFLEAIRQFRTEVGRHHVLFMHVTLVPWIPSAGEMKTKPTQHSVKELRSIGIQPDILICRCDRPLVPGIKEKLSQFCDVPVECVIPSPDAKSIYEVPLLLEREGLATQVLNLLNLEQRQPDLSQWQALVERLYGSHRPLEVAIVGKYVRLSDAYLSVVEALRHSAIALDQELRIRWVNSEELVENGVETALSNVGAIVVPGGFGIRGVEGKIAAIQYAREQGIPFLGLCLGMQCAVIEWARHIAGLENANSAEFDANTPHPVIHLLPEQQDIVDLGGTMRLGLYACRLAPHSLAEKLYGETVIYERHRHRYEFNNAYRNLFLETGYQITGTSPDGRLVEIIEYPAHPFFIAVQFHPEFRSRPNAPHPLFYGLLAAAAKNSNRDHPQLVPSF
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ACCD_ECOUT
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXON_RHIME
Sequence: MDRVRTVRKAVIPVAGNGTRFLPATKAVPKEMLTIVDRPVVQYAVDEARQAGIEHIVFVTSRNKQVIEDHFDDAPELISSLSRSGKSAQISELEAMLPAAGSVSFTRQQAPLGLGHAVWCARDLIGDEPFALLLPDMVSFGARGCVAGLMDLYHEVGGNVVGVEQCAPEEASKYGIVGKGETVRHGFSVTEMVEKPAAGKAPSNYYLNGRYILQPEIFSILAHQTRGAGNEIQLTDGMLTLSQSQSFHAHPYEGRTFDCGSKQGFIEANVAFALARADIGDIVFESVRDMVLSHESRIRAA
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: TRPD_LEPBL
Sequence: MEPRAIVLKLIEHKHISVEEAEFFMNRVMKGEVSEILLSSFVTAMRAKGESVDEVLGCTLALRKNALKPKTVFPFDLLDTCGTGGDGQGTINVSTLSAITLASLGVKVAKHGNRSVSSHTGSSDILARLGYQTEATQEEVEAHLISRGFTFLFAPMWHPSMKYAGSVRKELGFRTVFNMIGPLSNPFSPQFQIIGVYQPELTELFIKVLQYLGLKRALVCHSRDGLDEFSIFQTTDYTLLENEVISRHSFDPRTLGFSSLKREEVYADSSEHAEVLARRVLNSEPIAGTHAVALNAGAGLFVMGKVKTIEQGYKIAWEALLSGKTRKYFEDLISKE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: KAD_PELUB
Sequence: MNIILFGPPGAGKGTQAQSIVKKHNYFQLSTGNLLRDEVKSKTDLGVDIEKLISNGKFVSDEIVNTLLRQSLTNLKYRDRIIFDGYPRNVEQAINLEVLLNEFNQTIGHTIFLNVSRDIIEKRIMGRMTCEKCNMTLNEYFNKEQIELHPCGVEHLKKRKDDNLEIVISRYDTYMSSTKPVLEFYSKNSNFTEIDGAGEIDQITNKINEILKV
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORNE_PLAOR
Sequence: IYVRPTKDELLYCGEFRELGQPDKKCRCDGKPCTVGRCNFARGDNDDKCI
What is the function of this protein?
Potent inhibitor of fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex.  May prevent blood from clotting during either feeding and/or storage of ingested blood.
What are the official names of this protein?
Ornatin-E.
What is the protein family that this protein belongs to?
Belongs to the ornatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HDEB_SHIFL
Sequence: MNISSLRKAFIFMGAVAALSLVNAQSALAANESAKDMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEYCKKNPQKNLYTFKNQASNDLPN
What is the function of this protein?
Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach.  Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.
What are the official names of this protein?
Acid stress chaperone HdeB.
What is the protein family that this protein belongs to?
Belongs to the HdeB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y1066_LISMH
Sequence: MDSKDQTMFYNFGDDSIEEDVKKLMKQVYVALEEKGYNPVNQIVGYLLSGDPAYIPRHKDARSMIRRLERDEIIEELVKAYLKNNEIGEK
What are the official names of this protein?
UPF0297 protein LMHCC_1066.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: PGK_AROAE
Sequence: MNVKKLADLDVAGKRVFIRADLNVPQDEAGNIVEDTRIRASLPSIRYCLERSATVMVTSHLGRPTEGECRAEDTLAPIAVRLGELLGKPVRLIRDWVEGGFEVRAGEVVLLENCRCNKGEKKDNEELAKKMAALCDIYVNDAFGTAHRAEATTHGIARFAPVACAGMLMGAEIDALTKATENPARPLVAIVGGAKVSTKLTILKTLAEKVDQLIVGGGIANTFLLASGKRIGESLAEPELVKEAQAIMDMMKARGAEVPLPVDVVVADEVSALARANRIPVDEVGPHDRILDVGPKSSAKLAEIIAHAGTIVWNGPVGVFEHNQFAGGTKMMASAIAHSEAFCIAGGGDTLAAIAKFHIAQDIGYISTGGGAFLEFLEGKKLPAIAALEARFAD
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDC1_MOUSE
Sequence: MESTQVIDWDAEEEEETELSSGSLGYSVEPIGQLRLFSGTHGPERDFPLYLGKNVVGRSPDCSVALPFPSISKQHAVIEISAWNKAPILQDCGSLNGTQIVKPPRVLPPGVSHRLRDQELILFADFPCQYHRLDVPPPLVPRSLLTIEKTPRIRIESQNSRVLLAADSEEEGDFPSGRCVANGQRNTASPSATVVPESDEEVSSPAPSVPGPSSPFGLGSDTDEEQGQQPGVEESSLADSSGAAGEAEQPEANGTTAGIQAQPTEHKLKDTKVKKEAGRAGVSDGSVLERSPTLGEDSDTEVDEDHKPGFADSETDVEEERIPVTPPVAPVKKNQVLLAVGIGDPEAPGVAHLQDCLAGSGTDVEDKTALDVPLERNHTPMVINSDTDEEEEEEEEVSAALTLAHLKERGIGLWSRDPGAEEVKSQPQVLVEQSQSASGRDSDTDVEEESSGRKREIIPDSPMDVDEALTVTQPESQPPRRPNDADEYMDMSSPGSHLVVNQASFAVVGKTRAQVEEEVPGPSVILGEKHQVPLEGAQPPEEAWETAVQEGSSSPEAAASVRPSQQPVAEDAGTECATAVSEQESTLEVRSQSGSPAAPVEQVVIHTDTSGDPTLPQREGAQTPTGREREAHVGRTKSAKECCDAEPEDLCLPATQCFVEGESQHPEAVQSLENEPTQLFPCTLPQEPGPSHLSLQTPGADTLDVPWEVLATQPFCLREQSETSELHEAHGSQPSLPREPPGHQHLVHTSPVHTELLRIEGREIQTVEKAMGIPKEMADRMTPEREPLEREIRGRTENSERDVIGEELIQGTKDREPKKVLARDSQRKEADKDLEGNRESLEVEIEMSKDSQKRERKVEKPEPKREWEPADLEVTPDRGVTEEGSHDQKGQIASLTLKPGVGVKDLEGLASAPIITGSQADGGKGDPLSPGRQQRGRLSCQTTPAGKASRGDPEPPDHCLFSSVPEASTQSLLTSQSQKQSTPQPLFSTSSSEIPLPESLHTKPNVRPRRSSRMTPSPHSSAALKPNTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPVDPELQPSTSTEQPVIPKLTSQVTEGRVQMPEPLLTGPEIQSPTSTEQSVTPDRKPRATRGRPSKSPNKTPEPLISTGPELQPPTSIEQPVIPKPTSRVTRGRPRKSSVRTPESVVSTGPELQPLTSIEQPVIPEPRATRGRPSKSSIKTPESVVPTGPELQPLTSAKQPVTPNLTSRASRGRSSKSIRTPEPVVQTGPEFHPSTSTEQPDTREPSSQARTRRSAVKTPEASVPTTPELQPFTSKKQPAPKPTALVTQGRTYKPSTEDCESVGPVAPDFEPSTSTDHLVTPKVTDQSLTLQSSPLSASPVSSTPDLKPPVPIAQPVTPEPIPQANHQRKRRAAGKQGSRTVPLGHKSYSALSEPEPQSSASQSSGASEADSPRQKRPRRQASQKTVVIKEEPVETEVKEEPQETAIPTPEKRKRDHAEEVTQGKPTRSRRTKPNQETAPKVLFTGVMDSRGERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCALGKGIPILSLNWLYQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLCRARERRLLEDYEIHVTPGVQPPPPQMGEIISCCGGTFLPSMPHSYKLHRVIITCTEDLPRCAIPSRLGLPLLSPEFLLTGVLKQEATPEAFVLSNLEMSST
What is the function of this protein?
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle.  May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX.  Also required for downstream events subsequent to the recruitment of these proteins.  These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis.  ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
What are the official names of this protein?
Mediator of DNA damage checkpoint protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks (By similarity).
Protein: MUSC_HUMAN
Sequence: MSTGSVSDPEEMELRGLQREYPVPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGSAEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNLTWPFVVSGRPDSDTKEVSAANRLCGTTA
What is the function of this protein?
Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47.  May play a role in regulating antigen-dependent B-cell differentiation.
What are the official names of this protein?
Musculin, Activated B-cell factor 1, ABF-1, Class A basic helix-loop-helix protein 22, bHLHa22.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUCL3_MOUSE
Sequence: MAQPTSGLYSTFGFFICLLFFPASWEAGANTFQELQKTGEPPKFDHLLPLTQGLTHRASSDQKTSRQHPPDLPEATATQKAKNQCNTTRLVKPVHTPLDNAKAADYGNTTVRHEMPPASEKDLSSQGKHLMARNERSADDPRSTTSENGSDGKRLTSAPRRNTSCMPSTRRTSLTTKSGMRASPMGASASLRTTSQKPTTFHVSELIRQSSSPVYATETPRTSYNTLKTLTTSGPEHHTIPFASDKSVQITTEHIKEATSASEITRTQSTFTKYEGKTSPASESSSQAQVLPIKHHTTSASENTIPVSAKSTPSTEKATKPTASPTVFQRKTIVATKTVRATRTSERTPVFLETTQPAKATEDKSSTVPSHVHKTETMHQGTVGSLTSRTNLGLSTSEAHYPQQSTHSLPGGLHAAGETGENNSFPVWAIVIVILMAVIILLVFIGLILLVSCASRARHVLTQNSEEPEPQPEDKGSRNSYPVYLMEQQNLNLNQIPSPP
What is the function of this protein?
May modulate NF-kappaB signaling and play a role in cell growth.
What are the official names of this protein?
Mucin-like protein 3, Diffuse panbronchiolitis critical region protein 1 homolog.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: E4PD_SHEPA
Sequence: MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEPDPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVLISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTINVTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKSRT
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_NEIMA
Sequence: MDISDFDFTLPEHLIAQHPPEVRGSSHLLVALPDMPLQDRVFGDLPDYVEAGDVLVFNNTKVMKARLFGQKDSGGRIEALIERVLDSHTALAHIRSSKSPKPGMGLVFEGGIRAVMVGREGELFCLRFEGGETVYELLEQNGHLPLPPYIERAADADDDSRYQTVYAKYQGAVAAPTAGLHFTEELLRRLKDKGAVTAEVTLHVGAGTFQPVRVDKIEEHKMHSEWFEVPSETAAAVEAAKARGNKVWAVGTTSMRALESAARATGRLKAGQGDTDIFITPGYRFNVADRLVTNFHLPKSTLLMLVSAFSGMGHIRAAYRYAVEREYRFFSYGDAMVLGRNEGVVR
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PSEU2
Sequence: MENLDALVSQALEAVQSAEDINALEQIRVHYLGKKGELTQVMKTLGNLPAEERPQVGALINVAKERVTEVLNARKASFEQAELTARLAAECIDVTLPGRGQTSGGLHPITRTLERIEQFFTHIGYGIAEGPEVEDDYHNFEALNIPGHHPARSMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRSDSDITHSPMFHQIEGLLVDRDINFADLKGTIEEFLRVFFEKELAVRFRPSYFPFTEPSAEVDMECVMCSGKGCRVCKQTGWLEVMGCGMVHPNVLRMSGIDPEEFQGFAFGMGVERLAMLRYGVNDLRLFFDNDLRFLAQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHH_DANRE
Sequence: MRLSTAAALLTGFILAFSPAYDGCGPGRGYGKRRTPRKLTPLAYKQFSPNVAEKTLGASGRYEGKVTPSSERFKELTPNYNPDIIFKDEENTGADRMMTQRCKDKLNSLAISVMNLWPGVRLRVTEGWDEDGLHSEESLHYEGRAVDITTSDRDRNKYRMLARLAVEAGFDWVYYESKGHVHCSVKSEHSVAAKTGGCFPGRALVTMKDGSHRQIRDLQAGDLVLASEGSDGTGDLIYSEVLTFLDRRPITQKHFYVIRTEDGASVSLTAAHLLFMRVGNCSNRGEPKPGAVRTIFASDAQVGQCLLLGKLRKRFSQITHVGVREDQGLYPPLTAHGTVVVNDVLTSCYAAVNRQRLAHWAFAPLRLLYSWTGPDQVLKNGLHWYSQVLIGLGKLLLDSELFHPLALEATER
What is the function of this protein?
The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).  In the notochord, induces somite patterning and muscle pioneer differentiation (PubMed:8684485).
What are the official names of this protein?
Indian hedgehog B protein, IHHB, Echidna hedgehog protein, EHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Indian hedgehog B protein N-product]: Cell membrane; Lipid-anchor. Note=The N-product remains associated with the cell surface. SUBCELLULAR LOCATION: [Indian hedgehog B protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Note=Co-localizes with HHAT in the ER and Golgi membrane.
Protein: Y695_METJA
Sequence: MNLWEFRFGKSFLFIPNFIMKVLAFEELALFDIFDSLINVKINIYENGIECGFSFYKWDEFKGYKIEDKYIRLISKFPLIIRLIFVRDIYLRYDEELEGIIEKHLRQK
What are the official names of this protein?
Uncharacterized protein MJ0695.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0803.
Protein: ARNC_ECOUT
Sequence: MFEIHPVKKVSVVIPVYNEQESLPELIRRTTAACESLGKEYEILLIDDGSSDNSAHMLVEASQAEGSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.