PharMolix/UniProtQA huggingface dataset:
Protein: FPS_PANGI
Sequence: MSDLKTRFLEVYSVLKSELLNDPAFEFTDDSRQWVERMLDYNVPGGKLNRGLSVIDSYKLLKEGKELSDDEIFLSSALGWCIEWLQAYFLVLDDIMDSSHTRRGQPCWFRLPKVGMIAVNDGILLRNHIPRILKKHFRQKPYYVDLLDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLPIHRRIVQYKTAYYSFYLPVACALLMSGEDLEKHTNVKDILIEMGTYFQVQDDYLDCFGAPEVIGKIGTDIEDFKCSWLVVKALELSNEEQKKFLHENYGKDDPASVAKVKELYNTLKLQDVFAEYESKSYDKLIKFIEAHPSQAVQAVLKSFLGKIYKRQK
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).  Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:24933610, PubMed:27746309, PubMed:29378087).  Promotes the accumulation of ginsenosides (PubMed:24933610).
What are the official names of this protein?
Farnesyl pyrophosphate synthase, FPP synthase, PgFPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_MAGSA
Sequence: MSRIAKRFAKLKAENRAALVTFITAGDPDHATSQALLDGMPAAGADIIELGMPFTDPMADGPAIQLAAGRALAAGGSLRQTLEMVEAFRKTDAETPIILMGYYNPVYAWGAEKFAADAAKAGVDGLIIVDLPPEEADELVPFLRQAGIDFIVLTTPTSDDARLPVVLANASGFVYYVSIAGITGTASAAQSAIDEAVARIRRHTGLPVCVGFGIKDPAQAAEVARVADGAVVGSAIVSVLADNIGKPGAVSAPLALVKDLAAGVRGARN
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PANC_ALIF1
Sequence: MDIFSEILPLREQIKAWKREGKRIAFVPTMGNLHEGHLTLIRTAREHADIVVASIFVNPMQFNNADDLTNYPRTLDEDVEKLTAENVDLVFTPTPEIMYPEGLEKQTTVDVPVISTILEGASRPGHFKGVSTVVNKLFNIVQPDVACFGEKDFQQLALIRQMVIDMALDVEIVGVPTVREMDGLAMSSRNNLLTLNERQRAPVLARTMRWISSQMRGGRNDYLSLIEDASDQLRAADLQPDEIFIRDARTLQEPTEETTQAIILMAAFLGQVRLIDNLVVELAAASNDEEE
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB1F2_I00A1
Sequence: MGQEQGTPWIQSTGHISTQKEEDGQKIPKLEHRNSTQLMGHYQKTMNQVAMPKQIVY
What is the function of this protein?
May play an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm, host cytosol.
Protein: ATRF_ASPFU
Sequence: MADGSRLPESATSTTMETNTNEHAKVLSPDAETVPSSSMTATSSELSLDGRWGERDQGEPVSRRGAMEDFEEMRRELTQLSLRRTRSVGKDAHRLRSRASGRASQVHDEEKAIDEEDSTIDGDGDGYQGGFDLGEFLMGGHLERRTTTGEPAKKVGVLFKHLTVKGVETGASFVRTLPDAVVGTFGPDLYRIVCSFIPQLRFGKQPPVRELLHDFTGLVREGEMMLVLGRPGAGCSTFLKTIANDRGAFAGVEGEVRYGGLSAEEQLKHFRGEVNYNPEDDQHFPSLTVWQTLKFSLINKTKKHDKNSIPIIIDALLKMFGITHTKNTLVGNEYVRGVSGGERKRVSIAETLATKSSVVCWDNSTRGLDASTALDYAKSLRIMTDVSKRTTFVTLYQAGESIYELMDKVLVIDSGRMLYQGPANKAREYFVNLGFHCPEKSTTADFLTSICDPNARQFQPGREASTPKTPEELEAVFRNSETYKTICDEVASYEKKLQDTDQEDTRRFQKTVAQSKSRTVSKKSSYTVSFARQVLACVQREFWLLWGDKTSLYTKYFIIISNALIVSSLFYGESLDTSGAFSRGGALFFSILFLGWLQLTELMPAVTGRGIVARHKEYAFYRPSAVSIARVVMDFPAIFCMVVPFTIIMYFMTGLDVTASKFFIYFLFVYTTTFSITSLYRMFAALSPTIDDAVRFSGIALNILVIFVGYVIPKQGLIDGSIWFGWLFYVNPIAYSYEAVLTNEFSDRIMDCAPSQLVPQGPGVDPRYQGCALPGSELGRRGVSGSRYLEESFQFTRSHLWRNFGVVIAFTVLYLIVTVLAAEFLSFVGGGGGALVFKRSKRAKKLATQTTQGNDEEKVQDVGDKAALSRGEAMSASNGESFKRISSSDRIFTWSNVEYTVPYGNGTRKLLNGVNGYAKPGVMIALMGASGAGKTTLLNTLAQRQKMGVVTGDFLVDGRPLGADFQRGTGFCEQMDLHDNTSTIREALEFSALLRQDRNVSKQEKLDYVDQIIDLLELNDIQDAIIGSLNVEQKKRVTIGVELAAKPSLLLFLDEPTSGLDSQAAFSIVRFLKKLSLAGQAILCTIHQPSSMLIQQFDMILALNPGGNTFYFGPVGHDGGDVIKYFADRGVVCPPSKNVAEFILETAAKATTTKDGKKIDWNEEWRNSEQNQRVLDEIQQIREERSKIPVTETGSPYEFAASTMTQTLLLTKRIFRQYWRDPSYYYGKLFVSVIIGIFNGFTFWMLGNSIANMQDRMFSIFLIIMIPPVVLNSIVPKFYINRALWEAREYPSRIYGWFAFCTANIVCEIPMAIVSSLIYWLLWYYPVGFPTDSSTAGYVFLMSMLFFLFMSSWGQWICAFAPSFTVISNVLPFFFVMCNLFNGIVRPYRDYPVFWKYWMYYVNPVTWWLRGVISSIFPTVQIDCSPSETTHFNPPPGQTCANYAGNFITNIAKNGYLLNPDASADCQYCPYSNGAEYMATLNVHDGDKWRCFGIFLAFVIINWLLVYFFIYTVRVRGWSFGMGYLFGGMGLVIDKVKGVFKRKSEKA
What is the function of this protein?
Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility (PubMed:26933209, PubMed:28080217).  Confers resistance to fluconazole and voriconazole (PubMed:26933209).
What are the official names of this protein?
ABC multidrug transporter atrF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PP4P1_XENLA
Sequence: MADGERSPLLSDLGDGGGMGAAMGPGAPSPGSALPTAPPYGGPGPASNKPQGFPEFPAAHGSVITGEDPPPYSPLTSPESGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPQGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHAGPLSPEPQPVGVRVICGHCKNNFLWTEFSDRTLARCPHCRKVSSIGMRYPRKRCFCCFLLGVLLALAAAGLVGGTWTLAYKYGGIYASWAILLLLALACIGRGIYWACMRVSHPVQSFS
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
What are the official names of this protein?
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 1 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: PLAT1_HUMAN
Sequence: MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY
What is the function of this protein?
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625).  Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847).  Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860).  Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847).
What are the official names of this protein?
Phospholipase A and acyltransferase 1, HRAS-like suppressor 1, HRSL1, Phospholipid-metabolizing enzyme A-C1.
What is the protein family that this protein belongs to?
Belongs to the H-rev107 family.
What are the subcellular locations of this protein?
[Isoform 1]: Membrane; Single-pass membrane protein. Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm.
Protein: COQ9B_XENLA
Sequence: MLVLTQPFLLMPRKLWVSSALRSDDQKQPPFSSSSTHAETPEHAEEQYQQQQSPPRYTDQAGEESEDYESEEQLQQRILTAALQFVPDFGWSADAIAEGAKSLDMSAAAGGMFEDGGSELVLHFVTQCNLQLTELLEKEHKLVQLGTSEKKPTAQFLRDAVKARLRMHIPYIEQWPQALGMLLLPRNIPSSLKLLSAMVDDMWHYAGDQSTDVSWYTSRAVLTGIYNSTELVMLQDSSPDFEDTWKFLENRISEAMTMGNSMKQVASTGEAVIQGLMGAAVTLKNLTGLNQRR
What is the function of this protein?
Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.  Binds a phospholipid of at least 10 carbons in each acyl group.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ9-B, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFTU_NITEU
Sequence: MAKSKFERVKPHVNVGTIGHVDHGKTTLTAAITTILTKKFGGEAKSYDQIDSAPEERARGITINTSHVEYETDKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIIVFMNKADMVDDAELLELVEMEIRELLSNYDFPGDDTPIIIGSALKALEGDKSDIGEAAILKLAEALDSYIPEPERAIDGAFIMPVEDVFSISGRGTVVTGRVERGIVKVGDEIEIVGLKPTIKTVCTGVEMFRKLLDQGQAGDNVGILLRGTKREEVERGQVLAKPGSILPHTKFTAEIYVLSKEEGGRHTPFFAGYRPQFYFRTTDVTGSIELPAGVEMVMPGDNISVTVNLIAPIAMDEGLRFAIREGGRTVGAGVVAKVIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RASH_MOUSE
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
GTPase HRas, H-Ras-1, Transforming protein p21, c-H-ras, p21ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity).
Protein: CAPP_TOBAC
Sequence: MATRSLEKLASIDAQLRALVPGKVSEDDKLVEYDALLLDRFLDILQDLHGEDLKETVQECYELSAEYEGKHDPKKLEELGNVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRQKLKRGDFADENNATTESDIEETFKKLVGDLKKSPQEVFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDEALQREIQAAFRTDEIRRTAPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERLPYNAPLIQFSSWMGGDRDGNPRVTLEVTRDVCLLARMMAANLYYSQIEELMFELSMWRCNDDLRIRAAELYRSSRRDTKHYIEFWKTIPPSEPYRVILGDVRDKLYQTRERTRQMLAHGISDIPEDATYNNVEQFLEPLELCYRSLCECGDRPIADGSLLDFLRQVSTFGLSFVRLDIRQESDRHTDVLDAITQHLEIGSYREWSEERRQEWLLSELSGKRPLFGPDLPRTEEIADVLDTLHVIAELPSDCFGAYIISMATAPSDVLAVELLQRECHVKQPLRVVPLFEKLDDLESASAAVARLFSIEWYRNRINGKQEVMVGYSDSGKDAGRFSAAWQLYKAQEELIKVAKEHGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTIQGSLRVTVQGEVIEQSFGEEHLCFRTLQRFTAATLEHGMHPPVSPKPEWRALMDEIAVIATEKYRSIVFKEPRFVEYSALATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKYAIDKDIKNLRMFHEMYNEWPFFRVTIDLVEMVFAKGNPGIAALYDKLLVSEDLLPFGELLRSNYEETRSLLLQIAGHKDLLEGDPYLKQRLRLRDSYITTLNLLQAYTLKRIRDPNYHVTLRPHISKDYMESKSAAELVQLNPTSEYAPGLEDTLILTMKGIAAGLQNTG
What is the function of this protein?
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB1F2_I83A6
Sequence: MEREQDTPWTQSTEHTNIQKEENGQQTQKLERPNSTQSMDHYLKIMNQVDMHKQTAFWKQWLSLKNPTQESLKTRVLKRWKLFNKQGWTS
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: BPT_PSEP1
Sequence: MTELARLKFYATQPHSCSYLPEEQATTLFLDPSQPMDVHVYADLSEMGFRRSGDHLYRPHCQNCNACVPARIPAARFIPNRQQRRILKRNADLTVTAARPAFKEEYFELYRRYIETRHADGDMYPPSRDQFSTFLVRDLPFCWFYEFRLEGRLMAVAVCDLLPNGLSAVYTFYEPDEDRRSLGRFAILWQITEALRQNLEAVYLGYWIKNCKKMNYKTQYRPIELLINQRWVTLN
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMMA_BACSU
Sequence: MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKLEHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRIYSHEISAFG
What is the function of this protein?
Involved in the regulation of horizontal gene transfer through the integrative and conjugative element ICEBs1.  Required for degradation of the ICEBs1 repressor protein ImmR/YdcN.
What are the official names of this protein?
Metallopeptidase ImmA.
Protein: LEPA_LEPIN
Sequence: MSDKQQFIRNFSIIAHIDHGKSTLADRLLEIGQVTNDRTKKDQILDSMDIERERGITIKANNATFDYLAEDGNTYIMNLLDTPGHVDFTYEVSRSLKACEGVLLIVDASQGVEAQTLANLYLAMEQDLEILPVMNKIDLPAADVEKTKIQIEESLGLDPQKAVAISAKTGLNVKEVLEQITKQIPSPKGNSNAPLKALVYDSYFDPYMGVVIKIRIFDGRIKKGDRILMMSTGKDFTVNEVGINRINLTPKESLETGEVGYIIAGIKKVSDAKTGDTVTLFSNPTKESVPGYKEAKPMVFAGLFPINGEQFDELVDAIEKLKLNDAALVFEKESSIALGFGFRVGYLGLLHMEIVQERLEREFNLDLITTAPSVKYIIRSKNGEVEEIDNPSRFPEPITIESTEEPYVKATVITPNEYVGNIMSLAMDKRGIQLDTVYLTQDKVQLTYEIPLAELIFEFYDKLKSFTRGYASLDYEPSGYKASQLVKMDILVNGEPVDALSMIVHRSKAEQRGREIIEKLKDLIPRHQFMIPLQAAVGGKILARESISALRKNVTAKCYGGDITRKKKLLEKQKEGKKRMKQIGNVEIPQEAFLAVLKTS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HIS8_STAAW
Sequence: MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTEEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RL10_BRUME
Sequence: MDRAEKREFVAWLNGAFKESGSVVVAHYTGLTVAQMSDLRSKMRDAGGSVKVAKNRLAKIALQGTESEGIADLFTGQTVVAYANDPITAPKVAVEFAKANDKLVILGGAMGATTLNADGVKSLASLPSLDELRAKLVGMIQTPAQRLAVLTSAPAGQIARVIGAHARKNEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SUB2_PLAFA
Sequence: MLNIIYVVSLILIKFIFYKECNNNNNYYLSNIELYNYKLRKRNRILNNNINDRKSFLSDLEQNYKPLFDIYELSANFEKRRKELEKKTKGEENEIEKKKENDLEEKKENEIEKKKENDLEKEYNDVINLLELSLSSEYKELNADVSNNDNSGHEENNKHKLNKKNSSNYKNDKSLDELIKGAILKLKQNPNIKNKNMLDYDKIFKIIKEKLINKNLASNKIKGGDNEKLKEEKKQSDISTNVEVKKDIINDQLNKGIPTKIENKDDMINKESNKEDITNEGKSNSLNNLNTLNNDGNIITKVYDHYTIVTNSNDILNDISIDASDISKNSIGGINIPFNENDNSSFTHQRYIVLSNNGEKKYKIVLMTKNPKFMDMDGIYDEEEKKESLIELNQKVNKEENTNLYDGTGTLYYGKKSKKEKENTQQKGGNNPNVDINILNNNNNNNNNNNNNSNNNSNSMNDEEINYNNNNNKESPSMFRRFINFLSFSGNENETEDTLIYHNKNDNSYKNKKEGTGKNNDNNDPNNNNNKKILLNVDKLVDQYLLNLKNNHTSKQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVENWSFSSTYHTYEADYIKEQDSVYDRSPKKKYIKASKKLYNNKYSFLNKFLNIEPLILFAKKLNSKRSNIEKEILNFLPKELRDYSTWNLSIIRVFNAWFLAGYGNKNVKVCVVDSGADIKHVDLNGNLYIPEYNEKYEMTQDFYNFMVKNPTDASGHGTHVTGIIGGVANDLGVVGVAPNITLISLRFIDGKKYGGSFHAIKALNVCILNKAPIINASWGSSHFDVNLHLAVERLKYTLNGKGSVLIAASGNKSNDNDISPLYPATFTFPHVYSVASISRNFEISPFSNYGHKSVHILAPGHHIYSTIPNNSYKIFTGTSMAAPHVCGVSALVYSVCYNQGFIPQAEEVLDILTRTSIKIISTKKRTINDSLVNAEGAVLTTLLGGLWMQMDCYFVKFNLEKGKKKHIPVVFSAYKKGVYETDIVIAIIPIDGKSKIYGEIHIPIKIVTDVNIPNFQESPRRGKNYTIDSNEAQHDEVLSYICENALYNLYEYDSHYLLASVILFFLALLSIFVGMIYMKSRKHSDKKCSKNLMKSNYIPEMDDGMEETQQLQQERRQYFRELFGENLEKNYDQHFVQDFGQDFRQDFKLGSTPDLKQYSDIDLQNKIQQPERKTVKIIINNFEDRKKETKRRLLKGLNYDGENAKKHDFTNESISNSRKNFKFSNNTEMKKNTIKSEDVKIASDDNVNKAMNQLDDMFMK
What is the function of this protein?
Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite (PubMed:16322767).  May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion (By similarity).
What are the official names of this protein?
Subtilisin-like protease 2, Merozoite surface sheddase, MESH, PfSUB2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, microneme membrane; Single-pass type I membrane protein. Note=In mature schizonts, localizes to micronemes at the merozoite apical region (PubMed:10551362, PubMed:16322767). Immediately after schizont rupture, secreted from the micronemes to the merozoite surface where it redistributes in an actin- dependent manner to accumulate at the posterior end of newly released merozoites (PubMed:16322767).
Protein: HSLV_DESVH
Sequence: MELKGTTILAVRGAQGVTIAGDGQVTMGQSIVMKHSARKVRRLYNGRVVAGFAGSTADAFTLFEHFEAKLEEHRGNLVRAAVEMAKSWRKDKYLRRLEAMLLVADNEHILVLSGNGDVIEPDDGIAAIGSGGPYALAAARALARHTQLDAETIAREAMRIAGEICVFTNDHLTVESAETQA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRS20_SCHPO
Sequence: MTAYAAIIGTKDNPVYELEMGPINEKLDRSLNSHLNQFIVHSSLDIVDQLQWTSNAFYMKTIDQFHEMYISAYVTPSNMRFMLLHQNQSADNIKLFFQELHELYIKTLMSPFYQPNQPIRSQAFDLKVRSIARRYL
What is the function of this protein?
Component of the TRAPP I and TRAPP II complexes.  TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.  TRAPP II seems to play a role in intra-Golgi transport (By similarity).
What are the official names of this protein?
Transport protein particle 20 kDa subunit, TRAPP 20 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. Sedlin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein: ISPF_SALPK
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLMKAAK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: DRS3_AGASP
Sequence: MAFLKKSLFLVLFLGLVSLSMCEEEKRENEVEEEQEDDEQSELRRSLWSSIKDMAAAAGRAALNAVNGIVNPGEQ
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive and Gram-negative bacteria and fungi (PubMed:31671555, PubMed:31422479).  Has been tested against E. coli (MIC=47. 50-128 uM), S. aureus (MIC=189. 98-512 uM), K. pneumoniae (MIC>189. 98 uM) and C. albicans (MIC>189. 98 uM) (PubMed:31671555, PubMed:31422479).  Probably acts by disturbing membrane functions with its alpha-helical amphipathic structure (Probable).  May penetrate bacterial membranes, but stay at the mammalian membrane surface (Probable).  Shows a very weak hemolytic activity (PubMed:31671555).
What are the official names of this protein?
Dermaseptin-SP3, DRS-SP3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: MPP10_YEAST
Sequence: MSELFGVLKSNAGRIILKDPSATSKDVKAYIDSVINTCKNGSITKKAELDEITVDGLDANQVWWQVKLVLDSIDGDLIQGIQELKDVVTPSHNLSDGSTLNSSSGEESELEEAESVFKEKQMLSADVSEIEEQSNDSLSENDEEPSMDDEKTSAEAAREEFAEEKRISSGQDERHSSPDPYGINDKFFDLEKFNRDTLAAEDSNEASEGSEDEDIDYFQDMPSDDEEEEAIYYEDFFDKPTKEPVKKHSDVKDPKEDEELDEEEHDSAMDKVKLDLFADEEDEPNAEGVGEASDKNLSSFEKQQIEIRKQIEQLENEAVAEKKWSLKGEVKAKDRPEDALLTEELEFDRTAKPVPVITSEVTESLEDMIRRRIQDSNFDDLQRRTLLDITRKSQRPQFELSDVKSSKSLAEIYEDDYTRAEDESALSEELQKAHSEISELYANLVYKLDVLSSVHFVPKPASTSLEIRVETPTISMEDAQPLYMSNASSLAPQEIYNVGKAEKDGEIRLKNGVAMSKEELTREDKNRLRRALKRKRSKANLPNVNKRSKRNDVVDTLSKAKNITVINQKGEKKDVSGKTKKSRSGPDSTNIKL
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein MPP10, U3 snoRNA-associated protein MPP10, M phase phosphoprotein 10.
What is the protein family that this protein belongs to?
Belongs to the MPP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.