PharMolix/UniProtQA huggingface dataset:
Protein: CLU_SCLS1
Sequence: MAATNEVIPTSENPSDVSGSSQKLATEETALANGVDHEEEDSGEAGGEVFQLTVVLPREPHKIPIIVSSQEAIHDVRQSIIELPGTFQYSCFHLEHKGERINDFVQISEVPGLTADSEIHLVEDPYTEKEARIHIVRVRELIGAAGDRTDTLNGIISGVSLLDSVTSAESTQNGTSTAPSHPMVGFDFQASGTLSTLLPKAQEPGPKTIKSISVSPWNPPPYHLRQKGHLLYLQVTTNEGEQFQITSHVSGFYVNKSSTGKFDPSPKSAPKAHSAHSLLALLGDLSPSFEDSFKRLQEYNNTKEPLATFQITNATPSNPWIVPSASAPLVAHQADITRTQENYLIAGIENSETLRDWNEEFQSTRELPKETVQDRVFRERLTSKLFADYNDAAARGAILVARGEIAPLNPTEGKDAQIFVYNNVFFSFGADGVGTFASEGGDEAARAAVGKDVMGVRMVNQLDIDGLFTPGTVVVDYLGKRIVGQSIVPGIFKQRDPGENQIDYGAVDGKDIVASDEKFVSVFEKLSKALKVKKHAVWDKDGKRHDLEGSIETKGLLGTDGRKYVLDLYRVTPLDITWMEEVGTALDSPKEADVASESAYPHRMTVIRPELVEAYWKVKMREWVNGELERKRQAQKTIEPTAEEKEPGAVAEASEASKSDEPTENGELAKKADESDKDAEPSKPAADQERIDIGDFKFALNPDAFSGQQPQTDEEKAEFAEDEQQVRLVCEFLRKTVLPELVNDLKEGDVGFPMDGQSLSRLLHKRGINIRYLGQVATLADGKRLESLRILAVQEMVSRAFKHVAGNYLRYLPIPLTSSCIAHLLNCLLGTDLNATPKPDVDEAMAALYPDADLKFKEVSPESLKRDIEAQILRRFRYTLDSTWTAAIKHLQLLREVSLKLGIQLEMKPYHFTKQSQTEAAAAPPTTNGEATKDAAPTGKSTNGKKKKKNAREGSPASITSVNASSPVTFNPDDILNTVPVIKEASPRSSLAEEALEAGRISLLQDQKKLGQELLLESLSLHEQIYGILHPEVARVYNSLSMLYYQLDEKEAAMELARKAVIVSERTLGVDNAETLLNYLNLGLIAHASGETKLALTYIKHALDLWKVVYGPNHPDSITTINNAAVMLQHLKEYHDSRTWFEASLKICEEVYGKHSINAATLLFQLAQALALDQDSKSAVNRMRESYNIFLTELGAEDKNTKEAEKWLEQLTQNAVSIAKHAKDVQARRNRAGIRVSPRVTLGQTQLQPQVGQTAEAAAGRDSRSSRGLDSRSIDELLKFIEGSDQANKNKKRPGRSNPKRRGGAAAAAGK
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Clustered mitochondria protein homolog, Protein TIF31 homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_SALPA
Sequence: MNFLAHLHLAHLADNSLSGNLLADFVRGNPATHYPPDVVEGIYMHRRIDVMTDNLPEAREAREWFRHETRRVAPITLDVMWDHFLSRHWTQISPDFPLQAFVGYAHAQVATILPDFPPRFVNLNDYLWSEKWLERYRDMDFIQNVLNGMANRRPRLDALRDSWYDLDAHYDALEERFWHFYPRMMAQAARKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: CDPAS_PYRCJ
Sequence: MNEIVQLFLLIWPPYVANGSAVLAARLRRRHPLDFGKNFLDGRRIFGDGKTFEGVAIGVSAGTLLGYAPNLAYSYLTLLDAFLLATAAIVGDLLGAFVKRRLCMPRGYPAFPLDQLDFLLMALLVYSLYRELHIPLLLAAVVLTPVIHRATNYAAYKLRLKKEPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_JANSC
Sequence: MRILITNDDGINAPGLDVLHTIATDIAGPGGEVWTVAPAFEQSGVGHCISYTHPTMISEFGPRRFAAEGSPADCVLAGLHDVLKDTPPDLILSGVNKGNNSAENTLYSGTIGAAIEAAIQGLPSIALSQYYGPGNISLDNPFEAASAHGADVIRKILAAPGAFESHPYKLFYNVNFPPVAAADVKGIRAVGQGFREGGTGMGMRADMAPNGRKFLWITGSPQNVPSGADTDATVNIDGYISVTPMRADLTAYDQLQSLKDAIE
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPP29_HUMAN
Sequence: MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL
What is the function of this protein?
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein subunit p29, hPOP4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CBPC3_BOVIN
Sequence: MSEDSEKEDYSDRTISDEDESDEDNFMKFVNEDIHQCALLTADSISDPFFPRTTQILLEYQLGRWVPRLRKPRDLYGVSSSGPLSPTRWPYHCEVIDEKIEHIDWTPSNPEPMYIPTGLEVEPLYANSKEETVVYLAEDAYKEPCFVYSRVGGNRTPLKQPVDNCDDTLMFEARFESGNLQKVVKVGEYEYQLTVRPDLFTNKHTQWYYFQVTNTQAGIVYRFTITNFTKPASLYNRGMRPLFYSEKEASAHNIGWQRIGDQIKYYRNNQGQDRHHHFSLTWTFQFPHSKDTCYFAHCYPYTYTNLQEYLSGINNDPVRSKFCKIRVLCHTIARNMVYILTITTPLKNSESRKRKAVILTARVHPGETNSSWIMKGFLDYILGNSSDAKLLRDTFVFKVVPMLNPDGVIVGNYRCSLAGRDLNRNYTSLLKESFPSVWYTRNMIRRLMEKREVILYCDLHGHSKKENIFMYGCDGSDRCKALYLQQRIFPLMLSKNCPDKFSFSSCKFNIQKSKEGTGRVVMWKMGIRNSFTMEATFCGSTLGNKRGTHFNTKDLESMGYHFCDSLLDYCDPDRTKYYQCLKELDEMEKHINLEKVIDDSDTSLKEITLDLETSSHASDSSESNDSQTDLLKLNSQIKTKKKQLKTKKERNSTIERHQNIREEEQEVCDKGHLVQRHKESDSDVTDTRPSISDDCIFDYFRRQLPNQGFFKILGLKFYCGYTHMISQTVIQKLSRDQQRCVLGTDKKNQETVQPRNNDLYGNCIKVTSLKCPLNKQTPIWTEKTRIPTEDLHHNLKSNMKECPSFQSKKADINWTDDEKRIYRDKNIAQTQEILQYLLPIMRSTKNVQTTQIKEVFNPRTSFQIQHQQKPSSNINIRKCSTSWTPPRNLPLISQRTLIVSTSKWLQPLDWKSSESSLPLGGPKKRRKYSRVKATKTKDMKAASSKWEMTPSSSEKDADKSLQAEGSSQQGTMQTAPHPTKTKGEQPKKKHGQPAFHLKLQRDT
What is the function of this protein?
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins.  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein.  Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate.  Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.  May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins.  Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins.
What are the official names of this protein?
Cytosolic carboxypeptidase 3, ATP/GTP-binding protein-like 3, Protein deglutamylase CCP3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PAFA_SALTO
Sequence: MERRIFGLETEYGVTCTYRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDSVADLVAHDRAGERILEGLLVDAEKRLHDEGIAGEIYLFKNNTDSAGNSYGCHENYLVSRHGEFGRLADVLIPFLVTRQLICGAGKVLQTPRGAVYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMNEVTTLLKVGAADIVLRMIESGVVMRDLTLENPIRAIREVSHDITGRRKVRLASGKEISALEIQQEYLAKATEFVERRGGDQTAKRVVELWGRVLSAVETGDLEPVAREIDWVTKLRLIERYQRKHDLPLSHPRVAQMDLAYHDLRRGRGLYGLLERRGQVDRAATDPEIFEAKETPPQTTRARLRGEFIRHAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRAYDERVERLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: PNP_GEOSM
Sequence: MVHTVQAECCGKTITIETGKIAKQASGAVMIKSGDTMVLVTAVAMKSAKEGQGFFPLTVNYQEKAYAGGRIPGSFFKREGRPSDNETLTCRLIDRPIRPLFPEGFLNDTQVMATVVSADKDNDPAILSMIGASAALMVSDCPFAGPIAGVKVGRVNGAFIANPTAEELEKSDLEIVIAASQEAILMVEGSAAEVSENDLLEAIFFGHAAVQPILAAQLELAKKVGTPKRVILAPVVNEELKARVAALAKEGMKQAVRIKTKVERHLAIDAITAETVAALAAEFEGSEKEVKGFIEDLEYDLVREHIIKDGQRIDGRDTKTIRAISTEVSLLPRAHGSALFTRGETQSIVAATLGTSVDEQRIDSLYGDSRKKFMLHYNFPPYSVGETSFRLAPGRREIGHGMLAERALQQVLPKHDDFPYTIRIVSDITESNGSSSMATVCGGSLSMMDAGIPIKAPVAGIAMGLIKEGDDFAILSDILGDEDHLGDMDFKVAGTAEGVTALQMDIKIGGVTREIMSAALAQAKAGRIHILGEMAKTIAASRGDLSAFAPRITTIWVKVDKIRDVIGSGGKNIRSVTEATGVSIDIDDTGKINIASTNKEACDLAIKMIRNLTAEAEEGKLYMGTVKKIMEFGAFVEIFPGTDGLVHVSELDTERVKNVSDILKEGDKVLVKCIGIDKQGKIKLSRKEALGQTFTE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUT2_YEAST
Sequence: MKPNNRTCDVITNKDESLPALLLPALNSYTCDDSLLKGQISSNGRYQPFGFSDCSLLPKRLNIQAGQGSMPVSSIQCADHSYSNWQKESEKTKLPKLGCPTEYTEYYKTVSSGETTDSAVVSSIATNRLKRKRQRDGPSCDSCRIKKIKCNATIIIFLQDRNLISSISSNLHYTLSQDDINQFRMKFFRKLPDVMGTYEVIKHLDKIVLFKACTSCSRRNQKNGKCLFSRGFTKSDMNVFPKINSKLKDKSIFEMTVDDYVAAGFQTL
What is the function of this protein?
Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway.  Involved in sterol uptake.
What are the official names of this protein?
Sterol uptake protein 2.
What is the protein family that this protein belongs to?
Belongs to the SUT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDC42_MOUSE
Sequence: MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:24352656).  In its active state binds to a variety of effector proteins to regulate cellular responses.  Involved in epithelial cell polarization processes.  Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase.  Regulates cell migration (By similarity).  In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections.  Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons (PubMed:25851601).  Facilitates filopodia formation upon DOCK11-activation (PubMed:22494997).  Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).  Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
What are the official names of this protein?
Cell division control protein 42 homolog, G25K GTP-binding protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Note=Localizes to spindle during prometaphase cells (By similarity). Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (By similarity). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome (By similarity). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (PubMed:22461490).
Protein: UD2A3_MOUSE
Sequence: MVSEKCVAAFFLLQLCWAGCGFCSKVLVWPCDMSHWLNLKTILEELGARGHEVTVLKYPSIIIDQSKRIPLHFENIPLLYEIETAENRLNEIANLAVNVIPNLSLWEAAKTLQDFFLQVTGDFESICRSVLYNQKFMDKLRDAQYDVVVIDPVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLPIPLSYVPVVMSELTDNMTFTERVKNMMFSLLFEYWLQQYDFAFWDQFYSETLGRPTTFCKTVGKADIWLIRTYWDVEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQSSGEHGVVVFSLGSMVKNLTEEKANLIASVLAQIPQKVLWRYSGKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLLCVVTLTFIITKFCLFVCQKLYMKESKKMGNRKKKN
What is the function of this protein?
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion.  They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
What are the official names of this protein?
UDP-glucuronosyltransferase 2A3, UDPGT 2A3.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RLUD_VIBVU
Sequence: MAQQIELTNTVKDSQLGQRLDQAIAELFADFSRSRLKEWLLDGKVTVDGNVVTKPRTKVMGGEVITVLAELEDEVRWEAQDIPLDIVYEDDDILVINKPRDFVVHPGAGTPDGTVLNALLFHCPEVAEVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVRALQKRNITREYEAIAIGRMTAGGKVDKPIGRHATKRTLMAVSPMGKPAVTHFRVAEHFREHTRIRLRLETGRTHQIRVHMSYLQHPLLGDAAYGGRARIPAGASEDVTAMIRNFDRQALHAVMLRFEHPITGEEMEFHAPVPDDMVELTETLRRDAQEHGLPDEY
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase D, 23S rRNA pseudouridine(1911/1915/1917) synthase, rRNA pseudouridylate synthase D, rRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: NADK_THEPX
Sequence: MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSDFIIALGGDGTILNVARLCAPFGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEKRMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAYVNNNYVDTYLADGVIIATPTGSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTDGQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_SALPC
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMTEAQKPDTASYRTFNDFFVRPLRDDVRPLNTDPNILVMPADGVISQLGRIEEDKILQAKGHNYSLEALLAGNYLMADKFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPEGEHEGSVALLKGQEMGRFKLGSTVINLFAPGKVNLIASLASLSVTKIGQPLATSTETFVAPEVEPAPLPADEIKAEHDASPLVDNKKDDT
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: H4_PEA
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PCRB_STAAS
Sequence: MYDIKKWRHIFKLDPAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVVFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHMYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: IF4E2_HUMAN
Sequence: MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKPRLNVP
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349).  Acts as a repressor of translation initiation (PubMed:22751931).  In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).  In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: HENMT_MOUSE
Sequence: MEMAESIPCNSVVGGNFKEVSPEKVIRFKPPLYKQRYQFVRDLVDRHEPKKVADLGCGDAKLLKLLKIYPCIQLLVGVDINEEKLHSNGHRLSPYLGEFVKPRDLDLTVTLYHGSVVERDSRLLGFDLITCIELIEHLDSDDLARFPDVVFGYLSPAMVVISTPNAEFNPLFPTVTLRDADHKFEWSRMEFQTWALHVANCYNYRVEFTGVGTPPAGSEHVGYCTQIGVFTKNGGKLSKPSVSQQCDQHVYKPVYTTSYPSLQQEKVLKFVLVGELLIQVDRLRLRYQRMLRDREKDRGPKPGDMDSCPAPHLLLGAVFTEAEKARIESSPKPFCEGEKFYIPLQRLLTYPKLHRLCADEDRVRSLIADSVCLSSDGSAVVVDLHNSWDYRPEEN
What is the function of this protein?
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.  This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation.  Stabilization of piRNAs is essential for gametogenesis.
What are the official names of this protein?
Small RNA 2'-O-methyltransferase, HEN1 methyltransferase homolog 1, mHEN1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. HEN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis.
Protein: RL3_CLOAB
Sequence: MKKGILGKKLGMTQIFNEEGKVVPVTVIEAGPCVVIQKKTSEKEGYDAIQVGFGTIREKLVNKPLKGHFAKGNVELKRFVKEFRLEDTSSYEVGAEIKADIFAAGEKVDVSGVSKGKGFQGTIRRWGAHRGPMSHGSKFHRAVGSMGGSSDPSRTFKSKKMPGHMGHVNTTVLNVEVAKVIPEKNLILIKGGVPGPNKSFVVIKNSVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: KATG_RHOP2
Sequence: MDAKTDDKDGGKCPFPHGGGRGRRNSDWWPEHLDISLLHRNSTLSDPMGKGFDYAREFESLDLDAVIKDLHALMTDSQDWWPADFGHYGGLMVRMAWHSAGTYRTTDGRGGAGAGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGNKISWADLYVLTGNVALESMGFKTFGFAGGRADTWEPEELFWGPEGSWLGDERYSGERELSDPLGAVQMGLIYVNPEGPNGNPDPVAAAKDIRETFARMAMNDEETVALIAGGHTFGKTHGAGDPSLIGAEPEGGALEDQGLGWKSSFGTGFGADAITGGPEVIWTQTPTQWSNHFFENLFGFEWELDKSPAGAKQWKAKGAEANIPDPFDPTKKRLPTMLTTDLSLRFDPAYEKISRRFLENPDQFADAFARAWFKLTHRDMGPKVRYRGKLVPKEDLIWQDPIPPVDHELVGDKDIAALKAKILGSGLSVSQLVSAAFASASTYRHSDKRGGANGARIRFAPQKDWEVNQPSDLAQVLSKLEAIQKEFNGAQTDGKKVSLADLIVLGGCAAVEKAAKDAGTDIQVPFTPGRMDALEEQTDADSFKVLEPRADGFRNFIGKRKQYMSPEESLVDRAQLLNLTAPEMTALLGGLRVLGGNVGHTTHGVFTERPEKLTNDFFVNLLDMKTAWSPSATTEVVYEGRDRKTGELRWTGTRVDLIFGSHSQLRALAEVYAQSDAQPKFARDFVAAWTKVMNADRFDIVAK
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: TRHO_PSEPW
Sequence: MTQPIVVAALYKFVTLEDYAELREPLLKAMLDNGVKGTLLLANEGINGTVSATREGIDGLLTWLRSDPRLVDVDHKESYCDEQPFYRTKVKLKKEIVTLGVPGVDPNNAVGTYVEPKDWNALISDPEVLLIDTRNDYEVAIGTFKGAIDPKTETFREFPEYIKANFDPSKHKKVAMFCTGGIRCEKASSYMLGEGFEAVYHLKGGILKYFEEVPQEESLWDGDCFVFDNRVTVRHDLTEGEYDQCHACRHPVNAQDRASEHYSPGVSCPHCWDSLSEKTRRSAIDRQKQIELAKARNLPHPIGYNYKAEA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RNH_XANAC
Sequence: MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCQIVLHTDSQYVRQGITEWMPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPRS_STAS1
Sequence: MLNNEYKNSALKIFSLKGNEPLAQEVADHVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSNPVNLHLMELLIMIDACRRASAANINIVVPYYGYARQDRKARSREPITAKLVANLIETAGADRMIALDLHAPQIQGFFDMPIDHLMGVPILAQYFKNETDIDPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPKPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKDVYACCTHPVLSGPAKERIENSAIKELVVTNSIQLDEKRKPENTKELSVAGLLAQAIIRVYERESVSVLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.