PharMolix/UniProtQA huggingface dataset:
Protein: COX2_GALVR
Sequence: MAHPLQLGLQDASSPIMEELLYFHDHALMIVFLISSLVLYTISLMLTTKLMHTSTMNAQMVETMWTILPAVILTSIALPSLRILYMTDEINNPLLTIKAMGHQWYWSYEYTDYTDLNFDSYMTPTLDLKPGELRLLEVDNRTVLPMETPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLSATRPGLFYGQCSEICGSNHSFMPIVLELVPLKHFETWSTLTS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS13_MALP2
Sequence: MARILGVDIPNNKRVVISLTYIFGIGKSRSQEILSKAKIDENKKVSALSEEELATIRKIASEYVIEGDLRREVAMNIKRLMEIGSYRGIRHRRNLPVRGQRTKCNARTRKGPRKTVANKKIETK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ATPD_MYCGE
Sequence: MINAQAFGTALFQLSEEQKQVKKIYEECHFFLKLMRNFKDGSLSFLLNSYTLTKPDKIRLVDKLFKNHFCQVFVDFLKVIILKGYFTLVEQAIKYFFDNVESQKHIQFIKIITAFELSSKQLNKIIAIMEKRFKTKVVYKTEIDRSLISGIRIESSSHLFEKNVRDELKRIMAHFI
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction (By similarity).
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TGT_STRSV
Sequence: MSTSPIQYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKQMGSGIILANTYHLWLRPGDELIARAGGLHTFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHSRPHDQGLFGIVQGAGFEDLRRQSAQDLVSMDFPGYSIGGLAVGESHEEMNAVLDFTTPMLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSEGRLVVKNAQFEEDFTPLDHDCDCYTCSNYTRAYIRHLLKADETFGIRLTSYHNLYFLVNLMKKVRQAIMDDNLLEFREDFIERYGYNKSSRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: KAE1_PYRAR
Sequence: MLVLGVESTAHTISLGLVKDGDVLGQVGKTYVPPSGLGIHPREAADHHSQMAPQLLSHLLYRHGVRLSDVDVVAYAAGPGLGPALRVGAVLARAIAIKLGVPIVPVHHGIAHIEIARYATKSCDPLVVLISGGHTVIAGYSDRRYRIFGETLDVAIGNAIDMFAREAGLGFPGVPAVERCGESADRLVEFPMPIVGQDMSYAGLTTYALKLLKEGVPLSVICKSLVEAAYYMLAEVTERALAFTRKSELVVAGGVARSRRLREILSQVGAYHGAEVKVVPDEYAGDNGAMIALTGYYAYKRGVYTTPEESFVRQRWRLDAVDVPWFWDLCNR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1, tRNA threonylcarbamoyladenosine biosynthesis protein Kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_VIBCH
Sequence: MSKRTFQPSVLKRKRTHGFRARMATANGRKVLNARRAKGRKRLSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: IMDH_HELPJ
Sequence: MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIGLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDALVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYYG
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: NUSB_CHLT2
Sequence: MSVMASDKACAPVRASRPFPKQKLRELVLQALYALEIDPEGEDSLVSLLMTEASVSKKNAAYALMFCRAIRANQPDLDALLDATIRTTTLARLTIIERNILRMMLFEHQQNQDCCPVPVAVLIAETTRLIKKFSYSEGSSLILAVLGSIFDHPAPALDTPLEPTSMCG
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: MIAA_MYCTO
Sequence: MRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRGMDIGTAKLPVSERRGIPHHQLDVLDVTETATVARYQRAAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPATDPSVRARWERRLAEVGVDRLHAELARRDPAAAAAILPTDARRTVRALEVVELTGQPFAASAPRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGLVEEVRTLLRNGLREGVTASRALGYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQRSWFRRDHRVHWLDAGVASSPDRARLVDDAVRLWRHVT
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GLPX_HAEIN
Sequence: MNRALAIEFSRVTEAAALAAYTWLGRGDKNAADDAAVKAMRYMLNLIHMDAEIVIGEGEIDEAPMLYVGEKVGSGLGELVSIAVDPIDGTHMTAMGQSNAISVLAAGGKNTFLKAPDMYMEKLVVGSNVKGIIDLNLPLEQNLRRIASKLGKSLSDLTVMVLAKPRHDAVIKQIHNLGAKVLAIPDGDVAGSVLCCLPDAEVDLLYGIGGAPEGVAAAAAIRALGGDMQARLIPRNEVKSDTEENKKIAANEIQRCAALGVKVNEVLKLEDLVRDDNLVFTATGITNGDLLKGISRKGNLASTETILIRGKSRTIRKIQSIHYLDDLYKILNI
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate.
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 2, FBPase class 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_BUCUL
Sequence: ASGLMARKQMEQLIKNCDEFNISLYDINNPNQGIVHVIAPEKGMTLPGMIIVCGDSHTSTHGAFGALSFGIGTSEVEHVLATQTLKQQRFKNMKIEIIGDVPQFVTAKDIILFVIGRLGSSGGTGYVIEFCGNVIKKMSMEERMTVCNMAIEMGAKSGIIAPDEITYSYLREKIYSPYGLFWKKSIDYWKTLKSDKDAFFDKCFTIDVSNLAPQVTRGTNPDQVTSINEKIPNYNKFHSIVQKNSAKSACKYMGLKEGTYLTDIFIDKVFIGSCTNARIEDLRSASTILKNRKIANNVKAIVVPGSGSVKQQAEMEGLDKIFINAGFEWRLPGCSMCLGMNNDRLNVGERCASHSNRNFEGRQGRGGRT
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: DAM_BPT1
Sequence: MKDFNDIETIDFAETGCSFTREAIASGGYYQALKTPTCKEISGRRYKGTNTPDAVRDLWSTPREVIAYLEGRYGKYDLDAAASEENKVCEKFYSQETNCLKRWWGKNKHVWLNPPYSRPDIFVKKAIEQMEHNNQIDMLLPADNSTAWFTEARQNAAEIIWIEADLTEDIDGNEYARSGRLAFISGETGKAVDGNNKGSVIFIMRELKEGEVQQTHYIPITSICPSVKNKRAKVRKVD
What is the function of this protein?
Methyltransferase that methylates adenine residues in the dsDNA sequence 5'-GATC-3' (PubMed:2180941, PubMed:3312202).  May prevent degradation of viral DNA by the host restriction-modification antiviral defense system (PubMed:376871).
What are the official names of this protein?
DNA N-6-adenine-methyltransferase, DAM, Orphan methyltransferase M.EcoT1Dam, M.EcoT1Dam.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: CIDA2_BACCR
Sequence: MKYVTLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLILFLLLSTRVLPLKWFELGAEKLIVFLPLFLIPSTTGLMEYGSFLFSKESIIFLLVVASTVVTLIVSGYISQLLITTKK
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidA 2.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. CidA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7L_STAEQ
Sequence: MTEYLSVSALTKYIKYKFDQDPHLQSVLIKGELSNFKKHSSGHLYFNVKDKESVISGMMFKGNASKLGFEPKEGDEVLIEARVSVYERRGNYQIYVNKMQLDGIGNLYQKLELLKKKLKKEGYFDQSNKKLIPKYPKKIAVLTASTGAAIRDIHSTINNRYPLVEQIQISTLVQGTQARQDIIEKIQYADSLDVDTIIVGRGGGSIEDLWNFNEEDVVKTIFNCQTPIISAVGHETDFTLSDFVADVRAATPTQAAVIATPDQYELLQQIKQYEYTLSRYIKQYIEHQKKQLNHISSYYKFKQPSLLYDQQIQKRDELERQLNHLLNTKVEKSKHHLKLLQQSFNFKNLNQQITQEKQSIYQLHSRLSKIMSNNITNLKTVLKNKLESLNNLSPTNTMLRGYAIVNKDNEVVTSTHKLNENDQISLTMKDGSVDATVKKVRCNDE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_ECOSM
Sequence: MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNLIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVEVKLHDERLSTVEARSGLFEQGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_XANAC
Sequence: MHCDVLWHNAQLMTLDAAAGGLGIVDDGIVACRHGHIVYAGAAAQAPALQPDTAHDCQRRWISPGLIDCHTHLVYAGNRANEFEQRLRGASYADIAAAGGGIVATVRATRAADDAALLAASLPRLDAMLAEGVTTLEIKSGYGLALDDEIKQLRVARQLGAQRKVEVVPTFLGAHAVPPGEQAQPYIDQVCTQMIPAIAAQGLAEAVDVFCEHLAFSQAQAEQVFIAAQAHGLRIKIHAEQLSNQHGAELAARYGALSADHIEYLDQHGVAAMAAAGTVAVLLPGAFYFTRDTQLPPIAALRTAGVPLALATDCNPGTSPLTSPLLAMNMAATLFRMTVDECIAGFTREAARALGRSERLGQLRAGMDCDLAIWNIDAPADLVYRMGFNPLHARVWRGHPC
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF1A_MOUSE
Sequence: MSQASKRKHVVQEVLGEHMVPSDHQQIVKVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKNHVRSLQKEGHWPEAFSEVAEKQNNMNRESQPELPAEPQLSGEGSSSEDDSDLFVNTNHRQYHESEEESEEDEEEEEEAA
What is the function of this protein?
Plays a role into cellular response to oxidative stress.  Decreases cell proliferation (By similarity).
What are the official names of this protein?
Probable RNA-binding protein EIF1AD, Eukaryotic translation initiation factor 1A domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the EIF1AD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TF2B_ORYSJ
Sequence: MSDSFCPDCKKHTEVAFDHSAGDTVCTECGLVLEAHSVDETSEWRTFANESSDNDPVRVGGPTNPLLTDGGLSTVIAKPNGAQGEFLSSSLGRWQNRGSNPDRSLILAFRTIANMADRLGLVATIKDRANEIYKKVEDLKSIRGRNQDAILAACLYIACRQEDRPRTVKEICSVANGATKKEIGRAKEFIVKQLEVEMGQSMEMGTIHAGDFLRRFCSTLGMNNQAVKAAQEAVQRSEELDIRRSPISIAAAVIYMITQLSDDKKPLKDISLATGVAEGTIRNSYKDLYPYASRLIPNTYAKEEDLKNLCTP
What is the function of this protein?
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
Transcription initiation factor IIB, General transcription factor TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DCLK_DROME
Sequence: MELEKVKINSLHCNDAVLSSLQASPSATSPQSVPSKANVVTEASIIEKTNQPHNVQEDNNYNRDCDSPESSSSEQDKELDDLRNLHSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSACLSNTPTADHIKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIYNLCGKKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTAEDFKLEAEEQRAINVIRKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIGNKGNECTTYKR
What are the official names of this protein?
Serine/threonine-protein kinase CG17528, Doublecortin-like and CAM kinase-like protein, Protein Pk1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: CO9_TAKRU
Sequence: MRTEAALQLGFCALCVMLALLGEGMGRELPDPPAVNCVWSRWAPWSSCDPCTNTRRRSRGVEVFGQFAGIACQGSVGDREYCITNAKCNLPPPRECSDSEFQCESGSCIKLRLKCNGDYDCEDGSDEDCEPLRKTCPPTVLDTNEQGRTAGYGINILGADPRMNPFNNDFFNGRCDKVRNPNTLQLDRLPWNIGVLNYQTLVEETASREIYEDSYSLLREMLKEMSIKVDAGLSFKFKSTEPSMSNNSLKLDASLEYEKKTMIKDVSELTNIKNKSFMRVKGRLQLSTYRMRSHQLQVADEFVAHVKSLPLEYEKGIYYAFLEDYGTHYTKNGKSGGEYELVYVLNQDTIKAKNLTERKIQECLKIGIEAEFATTSVQDGKAHAKLNKCDDVTTKSQGDVEGKAVVDNVMTSVKGGSLESAVTMRAKLNKEGVMDIATYQNWARTIASAPALINSEPEPIYMLIPTDIPGANSRIANLKQATADYVAEYNVCKCRPCHNGGTLALLDGKCICMCSNLFEGLGCQNFKGDKARVPAARPAVTQEGNWSCWSSWSNCQGQKRSRTRYCNTEGVLGAECRGEIRSEEYC
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C9 is the pore-forming subunit of the MAC.
What are the official names of this protein?
Complement component C9.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Protein: RPO6_SULIM
Sequence: MGLERDGILSQDLHFNEVFVSLWQNKLTRYEIARVISARALQLAMGAPALIDINNISLTDVISIAEEEFKRGVLPITIRRRLPNGKIILLSLRKS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_PSYWF
Sequence: MTTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHGLFDLDITCKGDTYIDDHHSIEDTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVVDISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWMTVHLDNLKGKNSHHQIECTFKAFARALRMACEYDERALNTLPSTKEAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSR_BACSU
Sequence: MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLNYYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELKKELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVKLAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQSMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFPPLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED
What is the function of this protein?
Transcriptional repressor for the ribose rbsDACBK operon.
What are the official names of this protein?
Ribose operon repressor.
Protein: SET_DROME
Sequence: MSSVPKRAKLDGAPADGNTSAAAGNNEEESEALEQIDACQNEIDALNEKASEEILKVEQKYNKLRKPCYEKRSELVKRIPNFWVTSFINHPQVSGILDEEEEECLHALNKLEVEEFEDIKSGYRINFHFDENPYFENKVLTKEFHLNSAAASENGDWPASTSTPIKWKEGKNLLKLLLTKPYGNKKKRNSEYKTFFDWFSDNTDPVNDEIAELIKDDLWPNPLQYYLVPDIEVEPEDEEDNEDNDEEAFDDEDGEDGEGEEEEEDEDDK
What are the official names of this protein?
Protein SET.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
Protein: COBT_PSEPK
Sequence: MTQAWWRDACQPLDNAAMDQARARQQQLTKPAGSLGQLEALAIQLAGLQGLERPTLDQVAITIFAGDHGVVEEGISAYPQAVTGQMLRNFVGGGAAISVLARQLQASLDVVDLGTIDAQLELPGVRHLRLGTGTANFARQPAMTENQLQAALQAGRDSAQRAAEQGAQLFIGGEMGIGNTTAAAALASVLLGCPASELSGPGTGLDNAGVQHKAEVIERALRLHGLRAEDPLQALACVGGFEIAALAGAYLGCAQAGVTVLVDGFICSVAALVAVRLNPQCRAWLLFAHQGAEPGHKTLLAALQAEPLLALGLRLGEGSGAALAVPLLRLACALHGQMATFAEAAVADRPA
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RF2_YERE8
Sequence: MFEINPVKNRIQDLSDRTAVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEEIVTTIDQLDQGMDDVTGLLELAIEADDEETFNEAVAELDILDGKLGQLEFRRMFSGEYDSANCYLDLQAGSGGTEAQDWASMLLRMYLRWAEAKGFKTEIIEESDGDVAGLKSATIKIIGDYAFGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRASGAGGQHVNKTESAVRITHIPTNIVTQCQNDRSQHKNKDQAMKQLKAKLYEFEMQKKNADKQMLEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGDLDKFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_VIBPA
Sequence: MSTDLQHIRIGLTNNHPCSYLPERQERVAVALDAELHTEQNYQLLMANGFRRSGDTIYKPHCERCHACQPIRISIPDFVLSRSQKRLLSKAKSLRWEMKTEMDAEWFELYSRYICKRHKNGTMYPPKRDEFSRFAQTTWLTTLFLHIYDESNQLLGVAVTDVMAQCSSAFYTFFEPDYPLSLGTLAVLYQVNYCQQNNEQWLYLGYQIDECPAMNYKTRFQRHQRLVNQRWQG
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_LEUMM
Sequence: MAKETYVRTKPHVNIGTIGHVDHGKTTLTAAISKVLAEKQGVDATDFAEIDNAPEEKERGITINTSHIEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVDYLVVFLNKTDLVDDEELVELVEMEVRELLSEYDFPGDDIPVLKGSALKALEGDPEQVKVIEELMDTVDSYIPEPARETDKPFLMPVEDVFTITGRGTVASGRVDRGVLTTGTEIEIVGLKDEVQKTTVTGIEMFRKTLEEAQAGDNIGALLRGVDRSNIERGQVLAKPGSIKTHKKFKAEVYVLTKEEGGRHTPFFTNYRPQFYFHTTDVTGVVELPAGVEMVMPGDQVTFEIELISPVAIEQGLKFTVREGGHTVGAGTVTDIED
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.