PharMolix/UniProtQA huggingface dataset:
Protein: MZT1_PICSI
Sequence: MDRTAAQNARESLDLAFSISNFLQTGLDRHTLSILIALCEHGVNPEALAAVVKELRREAAALHQHQDQS
What is the function of this protein?
Required for gamma-tubulin complex recruitment to the microtubule organizing centers (MTOCs).
What are the official names of this protein?
Mitotic-spindle organizing protein 1, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1.
What is the protein family that this protein belongs to?
Belongs to the MOZART1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle.
Protein: S35G5_HUMAN
Sequence: MAGSHPYFNLPDSTHPSPPSAPPSLRWHQRCQPSGATNGLLVALLGGGLPAGFVGPLSRMAYQGSNLPSLELLICRCLFHLPIALLLKLRGDPLLGPPDIRGWACFCALLNVLSIGCAYSAVQVVPAGNAATVRKGSSTVCSAVLTLCLESQGLGGYEWCGLLGSILGLIIILGPGLWTLQEGTTGVYTTLGYVQAFLGGLALSLGLLVYRSLHFPSCLPTVAFLSGLVGLLGCVPGLFVLQTPVLPSDLLSWSCVGAEGILALVSFTCVGYAVTKAHPALVCAVLHSEVVVALILQYYMLHETVALSDIMGAGVVLGSIAIITARNLSCERTGKVEE
What are the official names of this protein?
Solute carrier family 35 member G5, Acyl-malonyl-condensing enzyme 1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SLC35G solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: I1BF_CONRA
Sequence: GHVPCGKDGRKCGYHADCCNCCLSGICKPSTSWTGCSTSTFN
What is the function of this protein?
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels.  Produces general excitatory symptoms (By similarity).
What are the official names of this protein?
Iota-conotoxin-like R11.15.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYC_XYLFA
Sequence: MSLHLYNTLHRRVEPFEPLDPACPTMYVCGPTVYNYVHIGNARGPVVFGVLAALLRRRYGALRYARNITDVDDKINTAAQEQGVPISAITERFCAAYREDMKKLGVEPPDIEPEATAHMPQIIAMIEQLIERQHAYVAMEHVLFAVNSFADYGQLSRRDPEEMLAGARVEIAPYKRDPSDFVLWKPSSDQLPGWDSPWGRGRPGWHIECSAMAAAHLGETIDIHAGGIDLQFPHHENEIAQSRCAHGSSTFARVWMHNGMLNFEGAKMSKSLGNIETVHGLVAKHPPEALRYALLSAHYRKPLDWSEALIAQSVRTLNRLYGTLRDLAAYPAHPFIPGNIEAALDDDLNTPQALAELATLANEARIQLADTTHHAAAEVTAALTRLKAELLGAGLALGLLQQTPEAWFSQGTNESDETHIQALIDARGAAKQARDFVRADAIRAQLAAEGIVLEDTPHGVRWMKQHT
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPFR7_XENRU
Sequence: GLASFLGKALKAGLKIGAHLLGGAPQQ
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Caerulein precursor fragment R7, CPF-R7.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_SYNWW
Sequence: MKLDRKDLLGLRDLSREETELILNTAIPMKDVICRDIKKVPTLRGKALVTVFYENSTRTRTSFELAGKYLSADTVNLSVSTSSVQKGESLRDTIKTIEVMGFDLMVMRHAMSGTPHYVARNTRMRVINAGDGANEHPTQALLDMYTIKEKKGTLESLKVAIVGDILHSRVARSNIYGLSKFGCDIRVVGPATLMPPGIEKLGVKSYYSLDEAINGVDVINILRIQRERQVSGLFPSLDEYAQLYMLSPQTLARAKDDVLVLHPGPINRGVEISSELADSAQALINEQVTNGVAIRMALLFLMMGGGRDEITY
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TBA3_MOUSE
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-3 chain, Alpha-tubulin 3/7, Alpha-tubulin isotype M-alpha-3/7, Tubulin alpha-3/alpha-7 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OLCF_PENCN
Sequence: MMGVLEDQVIIVTGAASGIGMATAIAALREGARVFGVDIAPQPATLKENNKFRYAQCDLAVESSIDSVVSNCLEVFEGRIDALFNIAGVMDHHGSVDTVTDSDWDRCIAINLTAPLKLMRAVIPTMRAHKRGNIINMSSRAGVSGAAAGVAYTASKHGLIGLSKNVAWRFKGDNIRCNVVCPGGVATGIISNMDPSQFDHEALDTIKPILGAVYSNRPEGYTQMLPEEVAETVIFLASDQSARINGAVLPVDDAWSTI
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of 15-deoxyoxalicine B (PubMed:30090271).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase olcI (PubMed:30090271).  Nicotinyl-CoA is then a substrate of polyketide synthase olcA to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase olcH to yield geranylgeranyl-HPPO (PubMed:30090271).  Geranylgeranyl pyrophosphate is provided by the cluster-specific geranylgeranyl pyrophosphate synthase olcC (PubMed:30090271).  The FAD-dependent monooxygenase olcE catalyzes the epoxidation of geranylgeranyl-HPPO and the terpene cyclase olcD catalyzes the cyclization of the terpenoid component, resulting in the formation of the tricyclic terpene moiety seen in predecaturin E (PubMed:30090271).  The cytochrome P450 monooxygenase then catalyzes the allylic oxidation of predecaturin E, which is followed by spirocylization with concomitant loss of one molecule of water to form decaturin E (PubMed:30090271).  Decaturin E is the substrate of the cytochrome P450 monooxygenase olcJ which hydroxylates it at the C-29 position to form decaturin F (PubMed:30090271).  The short-chain dehydrogenase/reductase olcF may catalyze the oxidation of decaturin F to generate the 29-hydroxyl-27-one intermediate, and subsequent hemiacetal formation probably leads to the formation of decaturin C (Probable).  The dioxygenase olcK may be a peroxisomal enzyme that catalyzes the hydroxylation of decaturin C into decaturin A once decaturin C is shuttled into the peroxisome by the MFS transporter olcL (Probable).  Finally the cytochrome P450 monooxygenase olcB catalyzes the oxidative rearrangement to yield 15-deoxyoxalicine B (PubMed:30090271).  In the absence of olcJ, decaturin E may be shunted to a pathway in which it is oxidized to a ketone, possibly by olcF, to form decaturin D, which undergoes further allylic oxidation to yield decaturin G (PubMed:30090271).  Moreover, in the absence of oclK or oclL, oclB can convert decaturin C into 15-deoxyoxalicine A (PubMed:30090271).
What are the official names of this protein?
Short-chain dehydrogenase/reductase olcF, 15-deoxyoxalicine B biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: YBBV_ECOLI
Sequence: MNRPAILKKKAAKDVASVLKIIFLFYLFLIARLKQRYSIREIKRDLWNIRENYSSNAAIAKIYCRKRKASGPGKHLTILPYGWVRFITFPIM
What are the official names of this protein?
Uncharacterized protein YbbV.
Protein: HISX_COREF
Sequence: MLNVTDLRGHTPSKSDIRRALPRGGTDVVSVLPIVEPVVDDVQNRGAEAALDYGEKFDHIRPASVRVPAEVLKAAEDTLDPRVREAIEESIRRVRKVHADQKPREHTTELAPGGTVTERFLPIDRVGLYVPGGNAVYPSSVIMNAVPAQEAGVGTLVVASPPQADHGGWPHPTILAACSILGVDEVWAVGGAQAVALLAFGDDSADLEPVDIITGPGNIFVTAAKRLVRGVVGTDSEAGPTEIAILADDTANPVNVAYDLISQAEHDVMAASVLITDSEQLARDVNREIEARYAITRNADRVAEALRGKQSGIVLVDDIEVGIAVADQYAAEHLEVHTANAREVSERISNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGTARFSAGLSTHTFLRPVNLIEYDEAALKDISEVVINFADAEDLPAHGEAIRARFETLPTTTADTTDTPDATA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: GATB_ASPCL
Sequence: MLQQWLRQSPAAAGLLRCSRYRGPQAALLQLSPQRAPTYHAIRSLQTSAAESQERIPLRKQLKQGAKGLKAQKRQRRESEEASRQTWELTVGIEIHAQLNTETKLFSRASTSSTDTPNSNVALFDLAFPGSQPEFQAATLLPALRAAIALNCDIQPISRFDRKHYFYQDQPAGYQITQYYEPFARNGYIDLFKHDGIAPEDGDHVRIGIKQVQLEQDTAKSQEYPPSTQLLDFNRVSHPLIEIITMPQIHTPATAAACVRKIQSVLQSCSAVTTGMELGGLRADVNVSIRRRDEAPGTHQYGGIGGLGQRTEIKNLSSFKAVEDAIIAEKNRQIAVLESGGVIEGETRGWTIGSTETRKLRGKEGEVDYRYMPDPDLPPLYIGEDLVSGLRQALPTPPDELIELLAGSDYGLPIEDAKPLIELDDGARLEYYQDVVEILRSLQQDQDAKSRTILARVAGNWVLHEFGGLWTKADLAWDAHRVPPQTLAQIIDQLQRKRITGATAKQVLVMIFDGDRRSLPQLLEEENLLLRPLSREEYIALAETAMSQNPQMVEQIRSKNQLGKLGWFVGQMMRMGEKGRVEAQKADEILRELILGQSGSQP
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, Glu-AdT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HEMH_AQUAE
Sequence: MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELMGGKSPQYEQTLEQAKALQERLGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYPQYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLYIKAWAEQIKQSVEKPEEYHFLFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVIRNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISALEDLVKNEV
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPM2_ARATH
Sequence: MELADRAVGLLLSSISLSIFTYYTFWVIILPFVDSDHFIHKYFLPQDYAILVPVFAGIALLSLISVFIGMVMLKSKKKKA
What is the function of this protein?
Regulates the biosynthesis of dolichol phosphate-mannose.  Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPMS1.
What are the official names of this protein?
Dolichol-phosphate mannose synthase subunit 2, DPM synthase subunit 2, Dol-P-Man synthase1, Dolichol phosphate-mannose biosynthesis regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the DPM2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=May serve as regulatory subunit and membrane anchor for DPMS1.
Protein: O165_CONAE
Sequence: MKLTCVLIVAVLFLTACQLIAADDSRDLKRFSRRKMRDGMLNTKNTKRQCLPPLSLCTMDDDECCDDCILFLCLVTS
What are the official names of this protein?
Conotoxin ArMKLT2-022.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SLE1_STAS1
Sequence: MRKKIIATVIGTSALAAVTWTNADAATTYKVKSGDSLWSIANKYNMSVAKLKSLNNLTSNVIFPNQSLKVSGSTSSSTSSNTSTGSTYTVKSGDTLSGIAAKYGTTYQKIMSLNGLSNFNIYPGQKLKVSGAASSSSSNTSGNTSSGSTTTYTVKSGDSLSAIAAKYGTTYQKIMSLNGLTNFNIYPGQKLKVSGKASTGGSGSSSTGSAGYKTPVFNHSNLYDWGQCTWHVFNKRAQIGKGISTYWWNANNWDTAAAADGYTIDRKATVGSILQSDMGYYGHVAFVESVNANGSITISEMNYSASPGIVTYRTIPASQVSSYVYIH
What is the function of this protein?
Peptidoglycan hydrolase involved in the splitting of the septum during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase sle1.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: MYO1_ASHGO
Sequence: MAIIKRGVRQKTQPPAKRTTNIKKATFDSGKKKEVGVSDLTLLSKISDEHINENLKRRFENGSIYTYIGHVLISVNPFRDLGIYTDQVLETYKGRNRLEVPPHVFAIAEAMYYNLKAYNENQCVIISGESGAGKTEAAKRIMQYIAAASSSHEASIGRIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIRFNAQFEPCAGQITNYLLEKQRVVGQIKNERNFHIFYQFSKGASDRYRKTYGVQLPEQYVYTSASGCTSVDTIDDLNDYEATLEAMNVIGLSQAEQDEIFRLLSAILWIGNVTFMEDDEGNAKIADTSITDFVAYLLQVDAGLLVKSLVERTIETTHGMRRGSIYNVPLNIVQATAVRDALAKAIYNNLFEWIVDRVNVSLQALPGAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQEEYAKEQIQWTPIKYFDNKVVCELIEAKRPPGIFAALNDSVATAHADSNAADQAFAQRLNLFTSNPHFELRSSKFVIKHYAGDVTYDIGGMTDKNKDQLQRDLVELLNSTSNTFLATIFPDTGDKDSKRRPPTAGDKIIRSANELVDTLSKAQPSYIRTIKPNQTKSPLDYDDRQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPQCSYAGDYTWQGNTLDAVNLILRDTSIPVTEYQLGVTKVFIKTPETLFALENMRDKYWHNMASRIQRAWRRFLQRRIDSAIRIQRAIREMKHGNQFEQLRDYGNKLLGGRKERRAMSLLGYRAFLGDYLSCNELKSKGAFVKRKAGINDHVVFSINGQALHSKFGRSAQRLPKTFILTPSHFYIIGKTLVNNQLTYAVDYKIDVRQIVYVSLTNLQDDWVGIFVSNSTQPDPLINTYFKTELITHLKKLNNRIEIKIGPTIEYQKKPGKIHAVKSQINENAPPLGDIYKSSTIMVRRGRPGNCSQRKKPLSTRLPDTYTTRETGYKNAGHPTNIRQVQEPTHISHSQQHTSSNLGFVYSLNPSAVNHPRPVPSGSVGTTSTPPKQAASAAQAAYNPHKLGGNMDNSSAAYGNASALPNSAPSQAPKPASRPVPKPAPRPGPKPGPKPGPKPGPKPAPKPMPRPAKSVENSVPRPNAIEQGKTAPPPPPPPPPPPAAVPSEPVYEAAFDFPGSGSPNEFPLKKGDRIYVTRQEPSGWSLAKALDGSKEGWVPTAYIVESKAAFSQLEQPVASSAPLGNSGVATREAGTTSAATAAASAATPTAFSAGLADALAARANKMRHEDSGSDDNADDDW
What is the function of this protein?
Type-I myosin implicated in the organization of the actin cytoskeleton.  Required for proper actin cytoskeleton polarization.  At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly.  Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).
What are the official names of this protein?
Myosin-1, Class I unconventional myosin, Type I myosin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.
Protein: TIG_STAEQ
Sequence: MTATWEKKEGNEGVLTVTVPAEKVNKALDQAFKKVVKQINVPGFRKGKVPRPIFEQRFGVEALYQDAVDILLPEAYGEAIEETEINPVAQPEVNVTQIEKGKDFIFEATVTVEPEVKLGDYKGLEIEKQETDLSDEELQESIDHSLSHLAEMVVKEDGAVENGDTVNIDFSGSVDGEEFDGGQAEGYDLEIGSGSFIPGFEEQIEGMKTGDEKDVVVTFPEEYHAEELAGKEATFKTKVNEIKFKDVPELNDEIANELDSDAENVDEYKENLRKRLSEQKATEAENTEKEEAINKATENASIDIPEAMINTELDRMIQEFGQRIQQQGLDLQTYYQISGQNEEQLRDQMKDDAEQRVKTNLTLTAIADEENIEVSDEDIDKELEKMSEQFNISVEDIKSTLGNTDIVKNDVRIQKVIDLLRDNAKYVEATKED
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RNC_STAAB
Sequence: MSKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_PROM2
Sequence: MAHKKGTGSTRNGRDSNSKRLGVKAYGGEKVTAGSILIRQRGTSFLPGINVGKGKDDTLFALKEGTVSFESIKRNLRNRKRVNIVI
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CYSP_TRYCR
Sequence: MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
What is the function of this protein?
The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
What are the official names of this protein?
Cruzipain, Cruzaine, Major cysteine proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: SLD1_ARATH
Sequence: MAEETEKKYITNEDLKKHNKSGDLWIAIQGKVYNVSDWIKTHPGGDTVILNLVGQDVTDAFIAFHPGTAWHHLDHLFTGYHIRDFQVSEVSRDYRRMAAEFRKLGLFENKGHVTLYTLAFVAAMFLGVLYGVLACTSVFAHQIAAALLGLLWIQSAYIGHDSGHYVIMSNKSYNRFAQLLSGNCLTGISIAWWKWTHNAHHLACNSLDYDPDLQHIPVFAVSTKFFSSLTSRFYDRKLTFDPVARFLVSYQHFTYYPVMCFGRINLFIQTFLLLFSKREVPDRALNFAGILVFWTWFPLLVSCLPNWPERFFFVFTSFTVTALQHIQFTLNHFAADVYVGPPTGSDWFEKQAAGTIDISCRSYMDWFFGGLQFQLEHHLFPRLPRCHLRKVSPVVQELCKKHNLPYRSMSWFEANVLTINTLKTAAYQARDVANPVVKNLVWEALNTHG
What is the function of this protein?
Plays a major role as delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides with or without a hydroxy group at the 4-position.  The enzyme produces both the 8E and 8Z isomers (in a 4:1 ratio).  This structural modification contributes to the quantitative partitioning of ceramides between the two major sphingolipid classes, glucosylceramides and glycosylinositolphosphoryl ceramides.  Sphingolipids are important membrane components involved in environmental stress responses, such as resistance to chilling, and act as cell signaling molecules.
What are the official names of this protein?
Delta(8)-fatty-acid desaturase 1, Delta(8)-sphingolipid desaturase 1, Sphingoid long-chain base desaturase 1, Sphingoid LCB desaturase 1, Sphingolipid 8-(E/Z)-desaturase 1.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PB1F2_I03A0
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPSSTRLMDHYLRIMSPVGMHKQIVYWKQWLSLKNPTQGSLRTRVLKRWKLFNKQEWIN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: RS20_SYNY3
Sequence: MANIKSALKRIEIAERNRLQNKSYKSAIKTLMKKTFQSVEAYASDPNPEKLDTINTSMAAAFSKIDKAVKCKVIHKNNAARKKARLAKALQSALPAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: TDH_YERPY
Sequence: MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFNIGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMSGAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFPIDEFQQGFDAMRSGKSGKVVLSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_STAES
Sequence: MFKFNEDEENLKCSFCGKDQDQVKKLVAGSGVYICNECIELCSEIVEEELAQNTSEGFTELPTPKEIMDHLNEYVIGQEKAKKSLAVAVYNHYKRIQQLGPNEDDVELQKSNIALIGPTGSGKTLLAQTLAKTLNVPFAIADATSLTEAGYVGDDVENILLRLIQAADFDIDKAEKGIIYVDEIDKIARKSENTSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPNQELIQIDTTNILFILGGAFDGIDEVIKRRLGEKVIGFASNEADKYDEEALLEQIRPEDLQSYGLIPEFIGRVPIVANLETLDVAALKNILTQPKNALVKQYTKMLELDNVELEFSEEALSAISEKAIERKTGARGLRSIIEEALIDIMYDVPSSENVSKVVITEQTINEEIEPELYDDEGNLINKNKTSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: BETA_RHILO
Sequence: MLEADFVIIGSGSAGSAMAYRLSEDGKHSVIVIEFGGSDIGPLIQMPSALSIPLNMSLYDWGFASEPEPHLGGRVLATPRGKVIGGSSSINGMVYVRGHARDFDHWAEEGATGWGFADVLPYFKRMEDNDGGEDGWRGHGGPLHVQRGSRKNPLYGAFVEAGRQAGFELTDDYNGSKQEGFGPMEQTISGGRRWSAASAYLKPALKRKNVSLVKGFARRVIIENQRAIGVEIEAHKQIQVVKARREVIVAASSINSPKILMLSGIGPAEHLRENGIAVVADRPGVGRNLQDHMELYIQQESTKPITLNSVLNPFSKALIGAQWLFFKSGLGATNHFEAAAFVRSRAGVDYPDIQYHFIPAAVRYDGKAAAKSHGFQAHVGPMRSKSRGSVTLRSPDPKAKPVIRFNYMSHPDDWTEFRHCIRLTREIFGQSAFDAFRGQEISPGSHVQSDDDLDVFIRDHAESAYHPCGTCKMGRADDVTSVVDPECRVIGVDGLRVADSSIFPRVTNGNLNAPSIMTGEKASDHILGRTPLAPSNQEPWINPRWQVSDR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: BCRR_ENTFL
Sequence: MEFNEKLQQLRTGKNLTQEQLAEQLYVSRTAISKWESGKGYPNMESLKCISKFFSVTIDELLSGEELITLAETENRSNLKKIYNYIYGILDMMAVAFIFLPLYGNSVGGYVYAVNLLSFTATTPFNLAVYWSAFAALIIIGIGKIISTHLDKEKWGGIATKCSLTITALAVCFFAAAREPYITVLVFLLLIGKIFVWIKQMGMK
What is the function of this protein?
Functions as both a membrane-bound sensor and transducer of bacitracin availability to activates transcription of the bcrABD operon in the presence of bacitracin (PubMed:15388429, PubMed:18227063, PubMed:30777814).  Binds specifically to two inverted repeat sequences on the bcrABD promoter, irrespective of bacitracin concentration (PubMed:18227063).
What are the official names of this protein?
HTH-type transcriptional activator BcrR.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.