PharMolix/UniProtQA huggingface dataset:
Protein: SAM9L_MOUSE
Sequence: MSGQVTQPKLIKDWTKEHVRKWVTEDLNIVEKYAQILFKEEVTGMVLQELTEEDLREMGLPRGPALLIKRMYNKLISSPESHNQDSRELNDKKLSTKEQQTKTKNEEENSVSSNSDHGLRETGQNEEQEPSLTKENMLGDVVTKDMEDNKPKPEQMSCTPYPFDSFCDVKQYIEHSILRVAETGPLNLIDPIHEFKAFTNTKKATEEDIKMKFSNETFRFAAACMNSRTNGTIHFGVKDKPHGEIVGVQVTSKDIFVNHFNTMITKYFEDSEISEARACIREPRFVEVLLQNNTQSNRFVIEVDVIPRHSICQEKYFYIMMQSSTGKTWKQSKDTSLFVREGASSKNILGNPNQRDREFKKFLEDLKMWTASRKAAEEELRMVTKKESEGLKLSKLLTRHQGSLDESYYDWYILVTNTCAPTQLEHLEFIKEMKLFAVLDFDPYSHIKGVVKAYRESRIANLHLPSHYEEKTTIAEKISTLKLYEQPSWIFCNGRVDLSCQPLEPHLWQRDRASGVRRLISFLTDENIIVKGKVLVVFLLLSPIENQKDPLIETFCAFYQVFNGMDNMLCICVNSAIYQQWSDLLQVRLEIKDDLAKHSISTLNIELVNNTILKLKSVIQSSRRFLPSCGSSSVILEKMDEDIMSALEILCENECKDTDIEKDESQFLEFKKSREEHFYRGGRVSWWNFYFSSENYSSAFVKRDSFEELTTLIQQCADSPKPVFVKVINLYHHPGCGGTTLAMHVLWDLKQKFRCAVLKNKATDFVEIGEQVSKLMSYKATSHEDFIPVLLLVDDFEEQENAYILQNAINAFIAEKGLRYEKTLVIILNCMRSQNPDESAKLANSISLKYQLSPKEQRAFEAKLQEIEKEHKNCENFYSFMILKGNFDTTYIKNVVKNTLKDLDAKSRRAQLISYLALLNSYVTDSTISVSQCEIFLGITYTKKYGKPETVEKNMGTYSTLLIRTEVSDYGRYTGIRIIHPLIATHCLKELEMSYRMDKCQIALNMLEENVLYDSGLGRDKFKYDVQTLLLTRQRKEHGAETDTLFSPLIEELQNEETEKVLIAGSDRFPQNAFICQALARHFYIKEKNFSTALVWANLAKRKAPKNSYISDTLGQVYKSELNSGWEVAEKASKAFKESQNQSDSKDYGTEAWSPQNSQRRYDTFNTAGFFGEIEVGLDTIQLLQLTPLFHKENEISKESMAEFLSGKGTILSDPKGEYCVVLSKFTSLLQNLHSDLERCFHFFGDYMGFLKPRNTPKELTELLLSKKVSRCFKKYVELFCHLDTNLVQGKEDLLLQKENCRKRIQAWRADTFSGLLEYLNPNHKEANNIENIVGNYTFLLQDILNKQLSKVLTKDIQNFILANIILSCLKPSSKYILPFSTLKKKLREVLQIVGLTHSYPDPYFLACLLFWPENKELDEDSTLIEKYVSSLNRSFRRQYKHMCRSRQPSTLFYLGQKKGLNSLVHKAEIERYFSEVQDSNSFWHSGVVWEKREVKDLLRLLDGQAEGKLISLEYGTEAKIKIPVTSVYSAPLRSGRNIERVSFYLGFSIEGPLAYGIKVI
What is the function of this protein?
May be involved in endosome fusion.  Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
What are the official names of this protein?
Sterile alpha motif domain-containing protein 9-like, SAM domain-containing protein 9-like.
What are the subcellular locations of this protein?
Early endosome.
Protein: GON1_XENLA
Sequence: MKAFPTFALLFLVLLFSAHVSDAQHWSYGLRPGGKRDTESLQDMYHETPNEVALFPELERLECSVPQSRLNVLRGALMNWLEGENRKKI
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-1, Progonadoliberin I.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPG_STRAW
Sequence: MGAQLRVYKRRIRSVTATKKITKAMEMIAASRVVKAQRKVAASTPYATELTRAVTAVGTGSNTKHPLTTQAETVTRSAVLLLTSDRGLAGAFNSNAIKAAEQLTARLEAEGREVDTYIVGRRGAAHYNFRERKVTELWTGFTDEPTYADAKKVAGPLIEAIEKETADGGVDELHIVYTEFVSMMTQTAIDARLLPLSLEEVAEESSTQGEIRPLYDFEPSAEDVLDALLPRYVESRIYNALLQSAASKHAATRRAMKSATDNAGELINTLSRLANAARQAEITQEISEIVGGASALADATAGSDR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MRH4_ASPOR
Sequence: MSLAVRPPVCLLCRSGAPTLLPSSVSQVARSMATARLRRKVARMALSPDVAKSSINQKRSGKAKFGPWSGMNQTEAHIRGEPRSRSQAALRRSGEKAADTPRKSDSPLYKALKMQTTLAPVPYGRRTAVKSKIADITSFDHFPLLPVVRHSIFSQALPGLVDVTPTPIQRLAIPKLMEDSPDGKRGTKLEDGDPQYDQYLLAAETGSGKTLAYLLPLVDAVKRLEVEDKENERKEEERKAKEKEERLKNRAFDLEPEEPPLSNAGRPRVIILVPTSELVAQVGVKVKALAHTVKYRSGMISSNLTPRRIKSTLFNPDGIDILVSTPHLLASIAKTEPYVLSRVSHLVLDEADSLMDRSFLPTTTEIISKVAPSLRKLILCSATIPRSLDNLLRKRYPDIKRLTTPNLHAIPRRVQLGVVDIQKEPYRGNRNLACADVIWSIGKAGDSEPSEPFASYVGPNIKKILVFVNEREEADEVAQFLRSKGIDAQSLSRDSSARKQEEILAEFTESAPPPSPEEIMLAQKKRRQEDAIPFELPENHNKPENVRRLANTKVLVTTDLASRGIDTLPVKTVILYHVPHTTIDFIHRLGRLGRMNKRGRGIVLVGKKDRKDVVKEVREGMFRGQALI
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase mrh4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ZFAT_HUMAN
Sequence: METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNSSKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVLNLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEKVQKISGKEARQLSGAKKPIISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVFTSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEGRKEPEAPGEMPAPAVHLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDTSSAEAHAAPEKPPDMQHRSSVQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFSEDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETATEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGAETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL
What is the function of this protein?
May be involved in transcriptional regulation.  Overexpression causes down-regulation of a number of genes involved in the immune response.  Some genes are also up-regulated (By similarity).
What are the official names of this protein?
Zinc finger protein ZFAT, Zinc finger gene in AITD susceptibility region, Zinc finger protein 406.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: GDND_BACLD
Sequence: MEWICLIAAGILEMLGVTMMNQFHKDKRVRWIFLLIIGFAASFFLLSLAMETLPMGTAYAVWTGIGTVGGALVGILFYGEPKDGKRIFFIALILGSAVGLKLIS
What is the function of this protein?
Probably involved in guanidinium transport.
What are the official names of this protein?
Probable guanidinium efflux system subunit GdnD.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. YkkC/YkkD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QUEA_BRASO
Sequence: MRTDLFDFHLPPENIALRPASPREAARMLVVQGDGVLRDRTIGDLPDWLEPGDQLVVNDTKVIAAQLSGRRISRETEAKIEATLIKRLDGSRWQALVRPAKKLLAGDTIRFGNEGKVCLLGHLDATVEAKGEEGEVTLSFVFHGPALDQAIADLGRPPLPPYIAGKRPADEQDAQDYQTMFAAKEGAVAAPTAGLHFTPALEQRLRARGVGLQRVTLHVGAGTFLPVKVEDTEGHRMHAEWGSLTPETAAALNQAKAEGGRIVAVGTTSMRLLESAALPDGTIAPFEAETSIFITPGYRFRAVDILMTNFHLPRSTLFMLVSAFAGLETMQAAYAHAIESGYRFYSYGDACLLFRQPDERVVEP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHTB_VIBCH
Sequence: MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN
What is the function of this protein?
The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells.  It can bind five GM1 gangliosides.  It has no toxic activity by itself.
What are the official names of this protein?
Cholera enterotoxin subunit B, Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: AVLBB_WHEAT
Sequence: MKVFILALLALTATTAIAQLDTTCSQGFRQYQQQQQPGQRQLLEQMRPCVAFLQQQCRPLRMPFLQTQVEQLSSCQIDQYQCCQQLAQIPEQIRCHAIHNVVEAIMQQQSQQHRQERQQQAQHKSMRMLLETLYLMCNIYVPIQCQQQQQLGQQQQQQLQEQLTPCATFLQHQCSPVTVPFPQIRVDQPTSCQNVQHQCCRQLSQIPEQYRCQAIHNVAEAIRHQQPQQQCQGMYQPQQPAKLESIRMSLQALRSMCRIYIPVQCPAPTAYNIPMVATYTGGAC
What is the function of this protein?
Seed storage protein.  Might be integrated via inter-chain disulfide bonds within the glutenin polymer (By similarity).
What are the official names of this protein?
Avenin-like b11.
What is the protein family that this protein belongs to?
Belongs to the prolamin family.
Protein: RL20_STRSY
Sequence: MLEGGVVSRKRRKRILKLAKGYYGAKHLLFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVNDAAAFTALADAAKAKLAK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: LIPA_PYRAE
Sequence: MIPSWVSLRAGDYEKIINVRRALSRHGIYTVCEGAKCPNIFHCWGEGTATFMILGEVCTRACRFCAVRTGNPRGYVDWGEVDRLVEAVRELGLKYVVVTSVARDDLPDGGASVFAAVVKKLREVGCVVEVLVPDFGGSPASVKTVVSSGPDVFAHNVETVRRLTPLVRDRRAGYERSLSVLKYAKEFGAPLTKSGLMLGLGETFEEVVETLEDLRRADVDIVTIGQYIKPSGSPRHLNPVRYATPEEFAKIKEVAVSLGFKAVASGPLVRSSYKAYSLYREALKNIVYLG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_CORU7
Sequence: MARLAGVDLPREKRMEVALTYIFGIGPARSKELLEKTGISPDLRSKDLSDEQLAALRDVIENNWKVEGDLRREIQADIRRKIEIGSYQGLRHRRGLPVRGQRTKTNARTRKGPKKTIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CAND1_HUMAN
Sequence: MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
What is the function of this protein?
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.  Acts as a F-box protein exchange factor.  The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein.  Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
What are the official names of this protein?
Cullin-associated NEDD8-dissociated protein 1, Cullin-associated and neddylation-dissociated protein 1, TBP-interacting protein of 120 kDa A, TBP-interacting protein 120A, p120 CAND1.
What is the protein family that this protein belongs to?
Belongs to the CAND family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein: ADH1G_PAPHA
Sequence: MSTAGKVIKCKAAVLWEVKKPFSIEEVEVAPPKAHEVRIKMVAVGICRSDDHVVSGTLVTPLPAILGHEAAGIVEGVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCFKNDLSNPRGTMQDGTRRFTCGGKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGPAVKVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTIMASLLCCHEACGTSVIVGVPPDSQNLSINPVLLLTGRTWKGAIFGGFKSKESVPKLVSDFMAKKFSLDALITNVLPFEKINEGFDLLRSGKSIRTILMF
What is the function of this protein?
Alcohol dehydrogenase.  Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.
What are the official names of this protein?
Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_CLOBK
Sequence: MEKIKVALVSLGCDKNRIDSELMLYKLNEEAELVKNPKEAQVIIVNTCGFIETAKEESINTILQMASYKKTHNCKVLVVTGCLTQRYKGELKELIPEMDIMLGVNDYDKLLESIKVFLKSGEKSFYHKYSDTKINEGNRILTTPTYTAYVRIAEGCNNFCTYCAIPRIRGKYRSRKKENILKEVENLAKQGVKEIILIAQDTTMYGIDIYGKKVLHELLRDISKVEGVKWIRLLYCYPEEITKELIEEIKNNDKVCKYLDLPIQQISNSVLKRMGRKTTKETIINIIKKLRKEIEGITLRTSLIVGFPGETEGEFSELKEFVSDVKLDKLGVFKYSKEEGTSAALMEEQIDEEIKEKREEEIMILQQSISKDINKEKIGKIYEVIVEGIKEDMYYGRNYEMSPEIDGEIYFEKDENVRIGDIIKVKVTHSLEYDLIGVVYNELSK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VHL_HUMAN
Sequence: MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
What is the function of this protein?
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex.  Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions.  Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.  Ubiquitinates, in an oxygen-responsive manner, ADRB2.
What are the official names of this protein?
von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL.
What is the protein family that this protein belongs to?
Belongs to the VHL family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane- associated.
Protein: CYB_SPACY
Sequence: MTNIRKSHPLIKIINHSLIDLPAPSNISTWWNFGSLLGVCLMLQIVTGLFLAMHYTADTSTAFSSVTHICRDVNYGWLIRYLHANGASMFFILIYLHIGRGIYYGSFTLMETWNIGVVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGPNLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVMIHLLFLHETGSNNPSGLDSNSDKIPFHPYYTIKDTLGFMFMALTLTTLVLFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILILFPMLHLSKQRSMSFRPLSQCLLWILAANLTILTWIGGQPVEHPFITIGQLASVIYFFIILILMPTTSLMENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LSPA_PASMU
Sequence: MTKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLADHDGWQKYFFIVLAIAISLMLCYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVVDFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEPEQRTE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1679_HAEDU
Sequence: MIEHDDLALFRTAIKGTKKIKQDTFVPKTMPRKKVSEWRETQQQKDTEFFFSDEYEPLLKEENEKVKYLRADIDPYILKQLGRGDFQPDLFLDLHGLTRQKAKTELAALILACEREQVYCASIMTGYGTRTLKEQIPRWLVQHPKVIALHQAPKQWGGDAAILVLIEQPESLEKRLF
What are the official names of this protein?
UPF0115 protein HD_1679.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: KCJ16_MOUSE
Sequence: MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIAFHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYIPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCNSDTNTRRRSFSAVAVVSSCENPEETVLSPQDECKEMPYQKALLTLNRISMESQM
What is the function of this protein?
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  KCNJ16 may be involved in the regulation of fluid and pH balance.  In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
What are the official names of this protein?
Inward rectifier potassium channel 16, Inward rectifier K(+) channel Kir5.1, Potassium channel, inwardly rectifying subfamily J member 16.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Basolateral cell membrane. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10.
Protein: RAPZ_ECO57
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: NDHI_RIPO1
Sequence: MFNLLKQVSDYAKESIEAAKYIGQGLSVTFDHMRRRPVTVQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVDWEFNKAVKKKELKHYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELATYDRHELNYDNVALGRLPYKVTEDPMVTPLRELGYLPKGVLDPHDLPSGNQRSGKRPEEIIAESD
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: THIC_PSE14
Sequence: MSTTLKNAAHLSESAQVDSGSVQPFTRSQKIYVQGSRPDIRVPMREITLDVTPTDFGGEINAPVTVYDTSGPYTDPNVIIDVRKGLADVRSPWIDSRNDTERLAGLSSNFGQQRLSDAELTALRFAHVRNPRRANAGANVSQMHYARQGIITAEMEYVAIRENMKLQEARAAGLRTQQNAGHSFGASIPKEITAEFVREEIARGRAIIPANINHVELEPMIIGRNFLVKINGNIGNSALGSSIEEEVAKLTWGIRWGSDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVGGAAEDLTWELFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHQENFLYTHFEDICEIMKAYDVSFSLGDGLRPGSIADANDAAQFGELETLGELTKIAWKHDVQTMIEGPGHVPMQLIKENMDKQLECCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKDDVKTGIITYKIAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDTARSYHDETLPKDSAKVAHFCSMCGPKFCSMKITQEVREYAANQRIEAVDVDVAKGLAEQAERFKQEGSQLYKKV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.