PharMolix/UniProtQA huggingface dataset:
Protein: CLPT1_DANRE
Sequence: MAAQETQATQQSSVSNGEVSSNGAAASGQVAQTGATAQDPQQQQQQQPSAWQVIKGVLFRIFIIWAISSWFRRGPSTPDPNTPAGAPRVPSRNLFPKDTLMDLYVYISQSEIFTDFNNTEELFWYQQDLVYGEWTTGDSGDGCYEYYKELDLSESVKQNGSIYMHIYFTKSGFHPDPKRKGQYRRLSTVHATRMLNKYKRRKFLKTKNLLTGETEADPEMIKRAESHGPVEIISHWHPNLTINMVDDHTAWVKGSVPPPLDQHVKFDAVSGDYYPIVYFNDYWNLQKDYYPINDTLLNLPLRLTYCPLSLWRWQLYAAQSARSPWNFLGEDTYEQSDEDQDSVKVALLETNPYLLGLTIVVSIVHSIFEFLAFKNDIQFWNSRQSLEGLSVRSIIFGVFQSLVVLLYILDNETNFVVQVSVFIGLLIDFWKITKVMDVRLDRENRIAGIVPRLVFKDKSTYVESSTKIYDDMAFKYLSWLLYPLFGCYAVYSLLYVEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKMKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPMMYRIGCLRDDVVFFIYLYQRWIYRVDPNRVNEFGTSGVDHSKDSSAQPAAGETPAAITEKPEGEKKND
What is the function of this protein?
Involved in GABAergic but not glutamatergic transmission.  Binds and traps GABAA receptors in the endoplasmic reticulum (ER).  Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors.  Altered GABAergic signaling is one among many causes of cleft palate (By similarity).  Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity).  Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity).  May play a role in T-cell development (By similarity).
What are the official names of this protein?
Putative lipid scramblase CLPTM1, Cleft lip and palate transmembrane protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the CLPTM1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GREA_ROSCS
Sequence: MSDKPAYLTRDGRARLEAELEELVTKGRKEIAERINAAKELGDISESGEYEDAKNQQAHLEGRIREIKSILARAQIIDEENGSNHEVRIGSRVTVRIDGEHEEETWTIVGSTEAKPSEGKISNESPIGAALLGKRPSQQVTVETPSGTMKLTILNIQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRPO_PSEAE
Sequence: MSKVLIVDDHPAIRLAVRLLFERDGFTIVGEADNGAEALQVARKKSPDLAILDIGIPKIDGLEVIARLKSLKLDTKVLVLTRQNPAQFAPRCLQAGAMGFVSKRENLSELLLAAKAVLAGYIHFPTGALRSINQQSRDNEARMLESLSDREMTVLQYLANGNTNKAIAQQLFLSEKTVSTYKSRIMLKLNAHSLAGLIDFARRHELI
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Putative transcriptional regulator.
Protein: FUCA_METMP
Sequence: MDLTEFIKICRLLYDRKYVVGSGGNVSIRDGNLIYITPTGLSLGFLTKEDICIADLNGNIIKGKPTSELNMHLKIYQNKDSINAVVHTHSMYCTAFSALDKKLKLVTPEAEMVVKKIAYVDYFPCGSLELAENVSECIEDSIILKNHGIVTLGKDITEAYIKTEVLEEVAQLNYIMNNLK
What is the function of this protein?
Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde.  Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.
What are the official names of this protein?
L-fuculose phosphate aldolase, L-fuculose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: MDTG_ECOL5
Sequence: MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQISN
What is the function of this protein?
Confers resistance to fosfomycin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MMSF_MAGGM
Sequence: MVEAILRSTLGARTTVMAALSYLSVLCFVPLLVDRDDEFVYFHAKQGLVIWMWGVLALFALHVPVLGKWIFGFSSMGVLVFSLLGLVSVVFQRAWKLPVVSWVADRI
What is the function of this protein?
Plays a role in regulating magnetite crystal size; partially redundant function with MamF.
What are the official names of this protein?
Magnetosome protein MmsF.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamF/MmsF protein family.
What are the subcellular locations of this protein?
Magnetosome membrane; Multi-pass membrane protein.
Protein: NUOD_XANCP
Sequence: MSEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRDLPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQRTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: QUEG_FLAPJ
Sequence: MINNKSKYTNLIKSEAKRLGFLSCGISKAGFLEAEAPRLENWLNKQMNGQMSYMENHFDKRLNPTLLVDDAKSVISLLLNYYPSEIQNTNSYKISKYAYGQDYHFVIKEKLTALLHFIQTEIGEVSGRAFVDSAPVLDKAWAAKSGLGWIGKNSNLLTKQVGSFYFIAELIIDLDLEYDNPTTDHCGSCTACIDACPTDAIVAPYIVDGSKCISYFTIELKENIPTEMKGKFNDWAFGCDVCQDVCPWNKFSKPHNEPLFNPNPEVLSFTKKDWEEITEEIFKKTFKDSAVKRTKIGGLKRNINFLKD
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase, Queuosine biosynthesis protein QueG.
What is the protein family that this protein belongs to?
Belongs to the QueG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_PHAAO
Sequence: MSRYRGPRFKKIRRLGVLPGLTSKRPRSRSDLQTQLRFGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPLDIITTKDKERSKALIQNYLVSSPRGELPNHLTIDSLQYKGFVNQIIDSKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CML35_ARATH
Sequence: MKLAASLNRLSPKRLFRTKSKASVSRSEPSSFSSNASSSSSDGSYGNLKQGPTATPISVLPQNSGDFYTELVQAFKLIDRDDDGVVSRGDLAALISRLSHEPPSQEEVSLMLREVDGGDGGCISLEDLASRVAGTSGEGSVETEELREVFEIFDVDRNGKISAEELHRVFGVIGDERCTLEECMRMIATVDGNGDGFVCFDDFCRMMVPAMNDHHH
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML35, Calmodulin-like protein 1, Calmodulin-like protein 35.
Protein: VM33_BOTAT
Sequence: EQQRYLNATKYIKLVIVADNVMVRKYTHNLIDIRKRIFEIVNILSLIYLSMNINVALVGVDIWTNGDKINVTSAVEPTLASFGTWRERDLLNRKTHDNAQLLTGINLNGDTVGYAYIGSMCMPKQSVGIVQDHGKTYHLVAVTMAHELGHNLGMDHDRDSCTCLANSCIMSATISPSYQFSDCSQNDHLRYLISHTPQCILNEPLRTDIVSPEVCGNYLLEEGEECDCGPLWNCQNPCCNAATCKLTPGAQCAEGLCCYQCRFIKAGNVCRPPRSECDIAESCTGQSAHCPTDRFHRNGQPCLNNHGYCYNGNCPIMLYQCIALFGAGTTVAEDVCFNYNLDGQGFFYCRRENDRIFPCAKEDVKCGRLYCKVYNDNVHPCRYQYLDNGMVDHGTKCAVGKVCSNRQCVDVNTP
What is the function of this protein?
Snake venom zinc metalloprotease that induces apoptosis in vascular endothelial cells (VEC), without degrading the extracellular matrix (it cannot cleave collagen) or inhibiting adhesion of VEC.  Has also fibrinogenolytic and hemorrhagic activities (By similarity).
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like batroxstatin-3, Snake venom metalloprotease, SVMP, Vascular apoptosis-inducing protein-like, VAP-like.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_LACLM
Sequence: MGRSLKKGPFVDEHLMKKVEAQTNAERKSVIKTWSRRSTIFPNFVGLTIAVYDGRKHVPVYVQEDMVGHKLGEFAPTRTYRGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ISPF_CHLCH
Sequence: MRIGIGIDVHPFAAGRKLVIGGVYIPGHDGLDGHSDADVLLHAISDALLGAAALGDIGLHFPNTSAEFKDIDSMILLKHVGKLLAEHGYAPVNVDAMLLLEAPKIAPYIQQMRQNIADALGLQVGDVAVKATTNEKLGYIGRKEGAEAHAVCLIQGK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: FLGI_GLUOX
Sequence: MRFFTQSPFPLRTLTRRLTAFVCVGLLLLPGFTLAASVRIKDITDMEGVRSNQLIGYGLVVGLNGTGDRLTNTIFTRETLISMLNRLGVNIRDQETQLQTHDVAAVMVTADLPAFVHGGNRIDVTVSAAGDASSLTGGTLLVTPLMAADGEVYAVAQGSLATNAFSARGAAASITRNVPTSGHIANGGIVEREVPFDLSHRANLHLSLRNPDFTTASRIASIINRTFGPIAIVQDPRTVLLDLSNHDPVSTLSRIGDLLVTPDTPAKVVVDEASGTIIMGADVRISTVAVAQGNLTVQVTETPQVSQPGPFSGGQTAVVPRTNVKVDTGKTHHLAVVPGGTTLRELVSGLNALGVGPRDMISILQAIKADGALQAELEMR
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: Y184_CAMJJ
Sequence: MGVKAYLDGILGEDKACKFLKKQGFEILKRNFHSKFGEIDIIAKKDEILHFIEVKFTQNDYEVSERLDRKKLEKILKTIEFYHLKNGISSDFQIDLICIKNDVIQFCENISF
What are the official names of this protein?
UPF0102 protein CJJ81176_0184.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: ZUPT_SHIFL
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQLLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EHD2_ORYSI
Sequence: MLLSDLSSDQEATGSNSHGGGGGGDRMVVGSHGAAHVVLSNLFLPPAAAAAATMLLPAAPVMVRPAAMAAAQEPRAKKKRSLPGNPDPEAEVIALSPRALVATNRFVCEVCNKGFQRDQNLQLHRRGHNLPWKLRHRAAAVSAVTTAAPAPRKRVYVCPEPTCVHHDPARALGDLTGIKKHFSRKHGEKRWRCERCGKRYAVHSDWKAHVKNCGTREYRCDCGILFSRKDSLLTHRAFCDALAEESARLLAAANNSSSITTTTCNNSNISSNNNNNNINSISNSNNLLITSSSSSPPLFLPFSTTPAENPNPNQLLFLQQHQAAHHQLLLPQFQQPPSSPPAYFDHLAFGGGGGVITSSSCNDDNSSIAGDVMVAAGGDSVSFGLTSEGSVTMHAGDVGRRRLTRDFLGVDHDAGEVDELELDELPADLSTTAAACQGCNFAAATTVACCATDFTTGSRQYLGRLPPVNETWSHNF
What is the function of this protein?
Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock (By similarity).  Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1 (By similarity).  Seems to repress FTL11 expression (By similarity).  May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters (By similarity).
What are the official names of this protein?
Protein EARLY HEADING DATE 2, Protein RICE INDETERMINATE 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PEX12_CRILO
Sequence: MAEHGAHITTASVVDDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPAHYGFFWRWFDEIFTLLDFLLQQHYLSRTSASFSEHFYGLKRIVAGSSQQPQRPASAGLPKEHLWKSTMFLVLLPYLKVKLEKLASSLREEDEYSIHPPSSHWKRFYRAFLAAYPFVNMAWEGWFLTQQLRYILGKAEHHSPLLKLAGVRLGRLTAQDIQAIEHRLSEASVMQDPVRSVGEKIKLALKKAVGGIALSLSTGLSVGVFFLQFLDWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVLATSGYVFCYRCVFNYVRSHQACPITGYPTEVQHLIKLYSPEN
What is the function of this protein?
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity).  PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity).  When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Peroxisome assembly protein 12, Peroxin-12.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: RL1_ECOBW
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ATMA_ECO57
Sequence: MFKEIFTRLIRHLPSRLVHRDPLPGAQQTVNTVVPPSLSAHCLKMAVMPEEELWKTFDTHPEGLNQAEVESAREQHGENKLPAQQPSPWWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVINDKGENGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKAATTRQPEHSNPLECDTLCFMGTTVVSGTAQAMVIATGANTWFGQLAGRVSEQESEPNAFQQGISRVSMLLIRFMLVMAPVVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKHLDAIQNFGAMDILCTDKTGTLTQDKIVLENHTDISGKTSERVLHSAWLNSHYQTGLKNLLDTAVLEGTDEESARSLASRWQKIDEIPFDFERRRMSVVVAENTEHHQLVCKGALQEILNVCSQVRHNGEIVPLDDIMLRKIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEGYIAFLDPPKETTAPALKALKASGITVKILTGDSELVAAKVCHEVGLDAGEVVIGSDIETLSDDELANLAQRTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIQKPQRWNPADLGRFMIFFGPISSIFDILTFCLMWWVFHANTPETQTLFQSGWFVVGLLSQTLIVHMIRTRRVPFIQSCASWPLMIMTVIVMIVGIALPFSPLASYLQLQALPLSYFPWLVAILAGYMTLTQLVKGFYSRRYGWQ
What is the function of this protein?
Mediates magnesium influx to the cytosol.
What are the official names of this protein?
Magnesium-transporting ATPase, P-type 1, Mg(2+) transport ATPase, P-type 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MLO6_ARATH
Sequence: MADQVKEKTLEETSTWAVAVVCFVLLLISIVIEKLIHKIGSWFKKKNKKALYEALEKVKAELMLMGFISLLLTIGQGYISNICIPKNIAASMHPCSASEEARKYGKKDVPKEDEEENLRRKLLQLVDSLIPRRSLATKGYDKCAEKGKVAFVSAYGMHQLHIFIFVLAVCHVIYCIVTYALGKTKMRRWKKWEEETKTIEYQYSHDPERFRFARDTSFGRRHLSFWSKSTITLWIVCFFRQFFRSVTKVDYLTLRHGFIMAHLAPGSDARFDFRKYIQRSLEEDFKTIVEINPVIWFIAVLFLLTNTNGLNSYLWLPFIPFIVILIVGTKLQVIITKLGLRIQEKGDVVKGTPLVQPGDHFFWFGRPRFILFLIHLVLFTNAFQLAFFVWSTYEFGLKNCFHESRVDVIIRISIGLLVQILCSYVTLPLYALVTQMGSKMKPTVFNERVATALKSWHHTAKKNIKHGRTSESTTPFSSRPTTPTHGSSPIHLLRNAPHKRSRSVDESFANSFSPRNSDFDSWDPESQHETAETSNSNHRSRFGEEESEKKFVSSSVELPPGPGQIRTQHEISTISLRDFSFKR
What is the function of this protein?
May be involved in modulation of pathogen defense and leaf cell death.  Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
What are the official names of this protein?
MLO-like protein 6, AtMlo6.
What is the protein family that this protein belongs to?
Belongs to the MLO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DHH1_CHAGB
Sequence: MDRDVTNTKGLDFEDFGLKRDLLMGIFEAGFEKPSPIQEESIPVALVGRDILARAKNGTGKTAAFVIPALEKINPKVSKIQCLILVPTRELAMQTSQVCKTLGKHLGINVMVTTGGTGLRDDIVRLQDPVHIVVGTPGRILDLAGKQVADLSECPMFIMDEADKLLSIEFTPVIEQLLRFHPKDRQVMLFSATFPISVKDFSDKNMTSPYEINLMDELTLRGITQYYAYVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMAQQARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLINWDDRFNLYNIERDLGTEIQPIPQTIDKSLYVYENPESIPRPISNLKPAGIQQQQQLSIPSTAVGRLAGTGPPKRFWSVWPSRPRRVPRQSRPLWWPPWRTFPRLPARAGWAPELRRPARWPCAGPKPADIPCSAGLGLSLSHLFGALGGVLTIAISSPP
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHH1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: PYRB_ALKMQ
Sequence: MSLKGRHLIDPNQLSLAELDNIITLGLEIYRNPNHYREICKGKILGTLFYEPSTRTRLSFESAMLRMGGTVLGFSDANTSSAKKGESIADTIRVLDDYADLLVMRHPREGAPLLASQYATVPIVNGGDGGHQHPTQTLTDLITIHHNKGKIENLKVAFCGDLLFGRTVHSLLKTLSRFPNMEFVFISPSELKIPKHLKDEVIKSNNVEIVETTFLEKHMSEIDILYMTRIQKERFFNEEEYVKLKDSYILDLQKLRNAKEDLLIMHPLPRVNEIHPEVDTDTRAKYFEQAKLGVYVRMALMALQLGVIESC
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: HEM3_FRAT1
Sequence: MKQITIASRESKLALWQTNFVKNRIQLELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NUCG_MOUSE
Sequence: MRALRAGLTLALGAGLGAAAEHWRRREGKAPGLLGRVPLLPVVAADLPALPGGPAGGTGELAKYGLPGVAQLRSRESYVLSYDPRTRGALWVLEQLRPERLRGDGDRSACDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQRAMDDTFYLSNVAPQVPHLNQNAWNNLERYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRSYVMPNAPVDETIPLERFLVPIESIERASGLLFVPNILARAGNLKAITAGSK
What is the function of this protein?
Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512, PubMed:32095813).  The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (PubMed:32095813).  Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (PubMed:32095813).  Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512).  Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107).  GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (By similarity).  Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (By similarity).
What are the official names of this protein?
Endonuclease G, mitochondrial, Endo G.
What is the protein family that this protein belongs to?
Belongs to the DNA/RNA non-specific endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TORD_ECO57
Sequence: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLTAAVDELENRVATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPTDHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALRQWLPEFVARCHQYDSFGFYAALSQLLLVLVEGDHQNR
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity).
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_LEGPH
Sequence: MTNKTWGGRFKKSLDSSVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQEIYSALEEIRTEIKQGQYSFNERDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQQAQPVTLGAYFNAYQCMFSRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIELCSVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYNKDMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQCSLNELLKGG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.