PharMolix/UniProtQA huggingface dataset:
Protein: PLCD4_BOVIN
Sequence: MAYLLQGRLPINQDLLLMQKGTMMRKVRSKSWKKLRFFRLQDDGMTVWHARQAGGRAKPSFSISDVDTVREDHESELLRNLAEEFPLEQGFTIVFHGRRSNLDLVANSVQEAQTWMQGLQLLVGFVTNMDQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQEYAFQLFQTADTSQSGTLEGEEFVEFYKSLTQRPEVQELFEKFSSDGQKLTLLEFVDFLQEEQKEGERASDLALELIDRYEPSESGKLRHVLSMDGFLGYLCSKDGDIFNPTCHPLYQDMTQPLNHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPSGEPIVYHGHTLTSRIPFKDVVAAIGQYAFQTSDYPVILSLENHCSWEQQEIIVRHLTEILGDQLLTTALDGQPPTQLPSPEDLRGKILVKGKKLMLEEEEEEPEAELEAEQEARLDLEAQLESEPQDLSPRSEDKKKVVMCPLLCRPLCCQIMAQAPISKPGLLLFPKQKPKAILCPALSALVVYLKAVTFYSFTHSREHYHFYETSSFSETKAKSLIKEAGDEFVQHNAWQLSRVYPSGLRTDSSNYNPQEFWNAGCQMVAMNMQTAGLEMDLCDGLFRQNAGCGYVLKPDFLRDAQSSFHPERPISPFKAQTLIIQVISGQQLPKVDNTKEQSIVDPLVRVEIFGVRPDTTRQETSYVENNGFNPYWGQTLCFRILVPELALLRFVVKDYDWKSRNDFIGQYTLPWSCMQQGYRHIHLLSKDGLSLHPASIFVHICTQEVSEEAES
What is the function of this protein?
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).  DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores.  Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction.  May play a role in cell growth.  Modulates the liver regeneration in cooperation with nuclear PKC.  Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4, PLC-85, Phosphoinositide phospholipase C-delta-4, Phospholipase C-delta-2, PLC-delta-2, Phospholipase C-delta-4, PLC-delta-4.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Protein: NEP2_NEPGR
Sequence: MASPLYSVVLGLAIVSAIVAPTSSTSRGTLLHHGQKRPQPGLRVDLEQVDSGKNLTKYELIKRAIKRGERRMRSINAMLQSSSGIETPVYAGDGEYLMNVAIGTPDSSFSAIMDTGSDLIWTQCEPCTQCFSQPTPIFNPQDSSSFSTLPCESQYCQDLPSETCNNNECQYTYGYGDGSTTQGYMATETFTFETSSVPNIAFGCGEDNQGFGQGNGAGLIGMGWGPLSLPSQLGVGQFSYCMTSYGSSSPSTLALGSAASGVPEGSPSTTLIHSSLNPTYYYITLQGITVGGDNLGIPSSTFQLQDDGTGGMIIDSGTTLTYLPQDAYNAVAQAFTDQINLPTVDESSSGLSTCFQQPSDGSTVQVPEISMQFDGGVLNLGEQNILISPAEGVICLAMGSSSQLGISIFGNIQQQETQVLYDLQNLAVSFVPTQCGAS
What is the function of this protein?
Extracellular proteinase found in the pitcher fluid of carnivorous plants.  Digest prey for nitrogen uptake.
What are the official names of this protein?
Aspartic proteinase nepenthesin-2, Nepenthesin-II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACEB_YARLI
Sequence: MLRTRFINSVNSARAMSRNINTLSQFPYPTLQQEESFFKSQVEDIEKWWASPRYEGIKRPYTAEKVAIHRGTLPQTYASSVQAEKLFNIFTERGKQGLPVHTTGSVDPVQMTQSAPHQEVVYISGWACSSLLTTTNEVSPDFGDYPYDTVPNQVDRIFRAQGLHDKKAWHEWMSLSHEERVKRDQEGKGRIDYLRPIIADADTGHGGLSAVMKLAKLFAERGAAAIHLEDQLHGGKKCGHLAGKVIVPTGSHISRLNATRMQWDIMGCSNLVIARTDSESAKLLSSAADPSDHEYILGVVKPIKPLAEVLLTAEANGATADMVNKLELEWTKEAEMMTYDEAVQRALTEAGKSDKIEEYLTKAKGKSNFEARQIADELAGKHIFFDWDAPKTREGHYHVQCGIEPAIKRALAFAPYADLIWLETKTPDLAQAQAFAKRIREKFPGKWLVYNLSPSFNWSAHGYSDEQLKSFVWDLAKSGFVMQLISLAGLHSNAVATHELSTRFKTEGMKAYVDLVQRKEKELGCDVLTHQKWSGANYLDSIISTVQSGSSGTSSTGGDSTENQF
What is the function of this protein?
Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA.
What are the official names of this protein?
2-methylisocitrate lyase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SERP2_BOVIN
Sequence: MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM
What is the function of this protein?
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum.  May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).
What are the official names of this protein?
Stress-associated endoplasmic reticulum protein 2, Ribosome-associated membrane protein RAMP4-2.
What is the protein family that this protein belongs to?
Belongs to the RAMP4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: MURG_PROMT
Sequence: MPRLLIAASGTGGHIYPALSFADSLSNSWEIVWLGVPHRLEVELVPEKYNLIKLKVGGLQGNSFRKLFNLCKLLFASVQVSVLLRQKKINVIFTTGGYISAPSILGAKMAGIPVLLHESNAIPGKVTRLLGRFCDHVALGIPSASEYLQRCRTSFTGTPVRTEFLLEKSLPSWVPLGEGVLIVVMGGSQGAIKMNEMVRKILPCLIEKGCRVVHLTGKNDCFYRNRDQEKNHPNLVVRDFSDEIPALLRNADLAISRSGAGAICELMVTKTPSILIPFPSSTDQHQELNAAYMARFGGAIIVNQHDPEKNILKNIVSNLLDSNSLREMKLNMNNHDYSYPEKKIFEIIHSIS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GUN1_HYPJE
Sequence: MAPSVTLPLTTAILAIARLVAAQQPGTSTPEVHPKLTTYKCTKSGGCVAQDTSVVLDWNYRWMHDANYNSCTVNGGVNTTLCPDEATCGKNCFIEGVDYAASGVTTSGSSLTMNQYMPSSSGGYSSVSPRLYLLDSDGEYVMLKLNGQELSFDVDLSALPCGENGSLYLSQMDENGGANQYNTAGANYGSGYCDAQCPVQTWRNGTLNTSHQGFCCNEMDILEGNSRANALTPHSCTATACDSAGCGFNPYGSGYKSYYGPGDTVDTSKTFTIITQFNTDNGSPSGNLVSITRKYQQNGVDIPSAQPGGDTISSCPSASAYGGLATMGKALSSGMVLVFSIWNDNSQYMNWLDSGNAGPCSSTEGNPSNILANNPNTHVVFSNIRWGDIGSTTNSTAPPPPPASSTTFSTTRRSSTTSSSPSCTQTHWGQCGGIGYSGCKTCTSGTTCQYSNDYYSQCL
What is the function of this protein?
Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose (PubMed:2948877).  The degradation of cellulose involves an interplay between different cellulolytic enzymes.  Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs).  The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain.  Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).
What are the official names of this protein?
Endoglucanase EG-1, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU3_PSEU2
Sequence: MSKQILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHGVPLADETLERARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASSLKPEIVAGLDIMIVRELTGGIYFGAPRGTRVLDNGERQAYDTLPYSESEIRRIAKVGFDMAMVRGKKLCSVDKANVLASSQLWREIVEQVARDYPEVELSHMYVDNAAMQLVRAPKQFDVIVTDNLFGDILSDQASMLTGSIGMLPSASLDTANKGMYEPCHGSAPDIAGKGIANPLATILSVSMMLRYSFNLTDAADAIEKAVSLVLDQGIRTGDIWSEGKVKVGTQEMGDAVVAALRNL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANK_SALEP
Sequence: MTTLAIDIGGTKLAAALIDKNLRISQRRELPTPASKTPDALREALKALVEPLRAEARQVAIASTGIIQEGMLLALNPHNLGGLLHFPLVQTLETIAGLPTLAVNDAQAAAWAEYHALPDDIRDMVFITVSTGVGGGVVCDGKLLTGKGGLAGHLGHTLADPHGPVCGCGRVGCVEAIASGRGMAAAARDDLAGCDAKTLFIRAGEGHQQARHLVSQSAQVIARMIADVKATTDCQCVVIGGSVGLAEGYLEQVRAFLMQEPAPYHVALSAARYRHDAGLLGAALLAQGDTL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: COAT_PHMV
Sequence: MDSSEVVKVKQASIPAPGSILSQPNTEQSPAIVLPFQFEATTFGTAETAAQVSLQTADPITKLTAPYRHAQIVECKAILTPTDLAVSNPLTVYLAWVPANSPATPTQILRVYGGQSFVLGGAISAAKTIEVPLNLDSVNRMLKDSVTYTDTPKLLAYSRAPTNPSKIPTASIQISGRIRLSKPMLIAN
What are the official names of this protein?
Coat protein, Virion protein.
What is the protein family that this protein belongs to?
Belongs to the tymoviruses coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: TSAD_NEIMA
Sequence: MLVLGIESSCDETGVALYDTERGLRAHCLHTQMAMHAEYGGVVPELASRDHIRRLVPLTEGCLAQAGASYGDIDAVAFTQGPGLGGALLAGSSYANALALALDKPVIPVHHLEGHLLSPLLAEEKPDFPFVALLVSGGHTQIMAVRGIGDYALLGESVDDAAGEAFDKTAKLLGLPYPGGAKLSELAESGRPEAFVFPRPMIHSDDLQMSFSGLKTAVLTAVEKVRAENGADDIPEQTRNDICRAFQDAVVDVLAAKVKKALLQTGFRTVVVAGGVGANRKLRETFGNMTVQIPTPKGKPKHPSEKVSVFFPPTAYCTDNGAMIAFAGAMHLGKGREVGAFNVRPRWPLSEIVR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1AK_HETMG
Sequence: MKSQMIAAVLLIAFCLCVVVTARMELQDVEDMENGFQKRRTCKDLIPVSECTDIRCRTSMKYRLNLCRKTCGSC
What is the function of this protein?
Inhibits voltage-gated potassium channels (Kv1. 2/KCNA2) and facilitates acetylcholine release at the avian neuromuscular junction (PubMed:9298966).  Inhibits Kv1. 1/KCNA1 and Kv1. 3/KCNA3 with high potency (By similarity).
What are the official names of this protein?
Kappa-stichotoxin-Hmg1a, Kappa-SHTX-Hmg1a, Potassium channel toxin HmK.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1a subfamily.
Protein: PYRF_RHIPU
Sequence: MNTFKTYADRAARHPNGCAKALFELMERKQTNLSIAADVTTKKELLHIADACGPYICILKTHIDIIDDFDEDLVAQLCELAKKHDFLLFEDRKFADIGNTVKHQYGKGVYKIASWAHITNAHTVPGEGIITGLREVGLPLGRGLLLLAEMSSKGALTKGSYTTESVEMARRNQDFVFGFIAQHKMNEKDDEDFVVMAPGVGLDVKGDGLGQQYRTPYQVIVESGCDVIIVGRGIYGNPDQIEFQAKRYKEAGWNAYLERVQKH
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: SYY_CHLTR
Sequence: MQQLIDNLKKRGILDNSSAGLESLTVPVSAYLGFDPTAPSLHIGHWIGICFLRRLAAYGITPVALVGGATGMIGDPSGKSVERSLLDQAQVLDNSKKIAAALASYLPGIRIVNNADWLGSLSMVDFLRDVGKHFRLGSMLAKDVVKQRVYSEEGISYTEFSYLLLQSYDFAHLFKEHNVVLQCGGSDQWGNITSGIDYIRRRGLGQAYGLTYPLLTDSKGKKIGKTESGTIWLDPALTPPYELFQYFLRLPDQEISKVMRTLTLLDNEEIFALDERLTSDPQAVKKYIAEVIVKDVHGSEGLAQAQAATESFFASKGKSITEAELVALVESGVGVKVARADLIGKRWLDIVVELGFCSSRGQARRLIQQRGLYINQEPLADEQSILDGTQLCFDRYVLLSQGKRKKQVIDLN
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_BRUSU
Sequence: MEQRLEIEQFICRSDNYGVLIHDPESALTATIDAPDAYAIEAALERRGWTLDFIFTTHHHLDHVEGNEPLKEKFGVSIIGPEAEKAKIPGIDRTVKGGDEFTFGLFKVKVISTPGHTAGGISYYLPDAKVVFTGDTLFALGCGRLFEGTPATMFHSLEKLVALPGDTALYCGHEYTQNNARFALTIDPDNSALKERAKEIARLRAHERMTLPSTIALEMATNPFLRWHDRTIRARLGLQDAPDEAVFAEIRKRKDMF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: LPFS_SHIFL
Sequence: MRNLQPNMSRWAFFAKSVGTWNKSSCRS
What are the official names of this protein?
Putative fruR/shl operon leader peptide.
Protein: RS3_SYNY3
Sequence: MGQKIHPVGFRLGITKDHKSCWYADPKRYPELLQEDHKIRQYIEKTLNNAGISDIRIERKAEQIELGIHTARPGVVVGRGGSGIEQLREGLQKLLGSARQIRVNVIEVPNADADAALMAEYIGQQLERRVSFRRVVRQALQRAERAEVKGIKIQVSGRLNGAEIARTEWVREGRVPLHTLRADIDYAYRTALTTYGILGIKVWIFKGEVIPGQEAAIVAPPSQPRRKSRRQQFDDRSQDG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CUA1A_TENMO
Sequence: GLVGAPATLSTAPIAYGGYGGYGAYGGSLLRAAPIARVASPLAYAAPVARVAAPLAYAAPYARAAVAAPVAVAKTVVADEYDPNPQYSFGYDVQDGLTGDSKNQVESRSGDVVQGSYSLVDPDGTRRTVEYTADPINGFNAVVHREPLVAKAVVAAPAIAKVHAPLAYSGGYLH
What is the function of this protein?
Component of the cuticle of the larva of Tenebrio molitor.
What are the official names of this protein?
Larval cuticle protein A1A, TM-LCP A1A, TM-A1A.
Protein: CVFB_STAAM
Sequence: MALDKDIVGSIEFLEVVGLQGSTYLLKGPNGENVKLNQSEMNDDDELEVGEEYSFFIYPNRSGELFATQNMPDITKDKYDFAKVLKTDRDGARIDVGLPREVLVPWEDLPKVKSLWPQPGDHLLVTLRIDRENHMYGRLASESVVENMFTPVHDDNLKNEVIEAKPYRVLRIGSFLLSESGYKIFVHESERKAEPRLGESVQVRIIGHNDKGELNGSFLPLAHERLDDDGQVIFDLLVEYDGELPFWDKSSPEAIKEVFNMSKGSFKRAIGHLYKQKIINIETGKITLTKKGWSRIDSKE
What is the function of this protein?
Contributes to the expression of virulence factors and to pathogenicity.  Involved in the production of hemolysin, DNase, protease and protein A (By similarity).
What are the official names of this protein?
Conserved virulence factor B.
What is the protein family that this protein belongs to?
Belongs to the CvfB family.
Protein: APAG_CITK8
Sequence: MINSPRVCIQVQSVYIEAQSSPDDERYVFAYTVTIRNLGRAPVQLLGRYWLITNGHGRETEVQGEGVVGVQPHIAPGEEYQYTSGAVIETPLGTMQGHYEMIDEKGVAFTIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: MTFA_SALG2
Sequence: MIKWPWKAQEITQNEDWPWDDALAIPLLVNLTAQEQARLIALAERFLQQKRLVALQGFELDSLKSARIALIFCLPILELGIEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHSQRVVQAGQSWQQGPIILNWLDIQDSFDASGFNLIIHEVAHKLDMRNGDRASGIPFIPLRDVAGWEHDLHAAMNNIQDEIDLVGESAASIDAYAATDPAECFAVLSEYFFSAPELFAPRFPALWQRFCQFYRQDPSQRLRVSAAEGDYGEESEH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCA_SALDC
Sequence: MKTDTSTFLAQQIVRLRRRDQIRRLMQRDKTPLAILFMAAVVGTLTGLVGVAFEKAVSWVQNMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPEAAGGGFNLIPIAAAGNFSVGLLLFIFIARVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHLEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQAAKNQNAPAGENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUT_CROS5
Sequence: MQIKIIKLKEKAIIPKYEHDNDSGLDLVSTETVEIPSGESKLVKTGISIELPPNTEAQIRPRSGLALKHQITVLNTPGTIDEGYRGEIGVILINHGKRSFKVTEGMRIAQMVIAPVIRVKIQEVEQLSDTIRGQGGFGSTGV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: MALB_MALAU
Sequence: MPSQSPYHALSRYFSFPNRDHQAWWTGKGPLLGNMLADAGYPEQQQYQYLTLFNLHLIPALGPSESHGAGIDGAEWKSLLSGSGKLEFSMTYRKSAVSLRIAFEPTSLLAGTKKDVFNKRRTQQLLGDLERLDIDIDTVLYHPLFDTLVVSDEEEAALQNAGTVIPDSSRTQQLLALNLIEGNVRADLYVYPYVKALATGTASSTLLWAAVKKIDRYNRFRDALSILKGYFETYPSSTTNPMFLSSDLAAPRNAFCRLFFSETNFSWERVQHLWTLGGTLSDKPTLKGLELAKILWDILGISTAPASPDSFPLLFTFELRPEQPYLRQKLGIPVSGLTESAIANACVAFFERLGWDDHAASYRTNLSAY
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353, PubMed:31548667, PubMed:28777910).  The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading (PubMed:23213353, PubMed:31548667).  This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE (PubMed:31548667).  The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway (PubMed:31548667).  Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2. 2. 2]diazaoctane ring of premalbrancheamid (PubMed:31548667).  Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide (PubMed:31548667, PubMed:28777910).  MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C (PubMed:28777910).  Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D (PubMed:28777910).
What are the official names of this protein?
Prenyltransferase malB, Malbrancheamide biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: NADA_PECAS
Sequence: MNILFDSNETIYPFPPKPRPLSVDAKQHYRSRIKTLLRERNAVMVAHYYTDPEIQALAEETGGCVADSLEMARFGSTHSASTLLVAGVRFMGETAKILNPEKTILMPTLEAECSLDLGCPIDAFSRFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGSYVQKQTGADVLCWQGACIVHDEFKTQALQRMKILYPDAAILVHPESPQSVVEMADAVGSTSQLIQAAKTLPQRELIVATDRGIFYKMQQACPEKTLLEAPTAGEGATCRSCAHCPWMAMNGLEAIANGLEQGGHAHEIHVDAALREGALIPLNRMLDFAASLKLRVKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPAC_STRSY
Sequence: MSKFLVFGHQNPDTDAIASSYGWAHLEREVFGRDAEAVVLGTPNEETAFALDYFGVTAPRVVESAKAEGVSQVILTDHNEFQQSIADIKEVEVAAVIDHHRVANFETANPLYMRLEPVGSASSIVYRAFKENGVIPPKEVAGLLLSGLISDTLLLKSPTTHVTDPQVAAELAEIAGVNLEEYGLALLKAGTNLASKSAEELIDIDAKTFGLNGNDVRVAQVNTVDIAEVLERQAEIEAAMTAASVANGYSDFVLMITDIVNSNSEILALGSNMDKVEAAFNFKLENNHAFLAGAVSRKKQVVPQLTDAFNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_PSYIN
Sequence: MNINATLLGQAIAFAVFVWFCMKYVWPPLLAAIEDRQKKISDGLTQAERAGKDLELAQAKASEKLKEAKVQAAEIIEQANKRRNQIVEAAKTEAETERQKIIAQGEAEVEVDRNRVREELRLKVSALAIAGAEKIIKRSIDKEANSDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LST82_ARATH
Sequence: MFENKPDDSPVYLATASHDQTIRLWQARTGRCYFSFRYPDLHVNRLELTPEKGKLVAACNPHIRLFDLRSYNPHIPVRNFVSHTKNVMAVGFQYTGHMMYSGSEDGSVKIWDLRVRECQREFRSVSPVNTVVLHPNQTELISGDQNGNIRVWDLRADLCSCELVPEVGTPIRSLTVMWDGTMVVAANDRGTCYVWRSLCERQTMTEFEPLHKLQAHNSHILKCLLSPGNNRYLATASSDKTVKIWNLDGFKLEKVLTGHERWVWDCDFSMDGEYLVTASSDTTARLWSMRAGKEEMVYQAHRKATVCCTLLRD
What is the function of this protein?
Probable non-functional protein.
What are the official names of this protein?
Non-functional target of rapamycin complex subunit LST8-2, TORC subunit LST8 homolog 2, Lethal with SEC13 protein 8 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LST8 family.
Protein: RRFM_RAT
Sequence: MALGIRCFRLLHPAFSSYLADLSRPVSEVPMKTVRGRQRDHIQYSAHPAVPVRQFATKKAKAKGKGQPQARVNINTALVEDIISLEEVDEDMKSVMEALKDNFNKTLNIRTAPGSLDHITVVTADGKLALNQIGQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPKVTREHREMLVKLAKQNTNKAKENLRKVRTNAMNKLKKSKDKTSEDTIRLIEKQISQMADDTVAELDRHLAAKTKELLG
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
What are the official names of this protein?
Ribosome-recycling factor, mitochondrial, RRF, Ribosome-releasing factor, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NFUA_TERTT
Sequence: MLNVTITDSAQTYLRELLEKQACEGIGIRMFVSNPGTPQAETCIAYCRPGEAEEADHVMELSGFNAYFEDRSVPFLDEAKVDYAPDKMGGQLTIRAPNSKMPKISDDSPIEDKINYVLYNEVNPGLASHGGNVSLERLTDDGMAILRFGGGCQGCSAVDMTLKQGVEKTLMERIPELAGVRDVTDHSDKSNAYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.