PharMolix/UniProtQA huggingface dataset:
Protein: ABA4_BOTFU
Sequence: MSSQPFTNKVIALTGSASGIGLETAKLLASRGARLSLADIQEDKLKELQAXXESEYHVDVITTKVDVRKFGEVEAWINKTIDNFGKLDGSANLAGVAPESIGLKGIVEQDLDEWEFVLGVNLTGTMNSLKAQLKVMANNGSIVNASSIRGLTGAAKNASYSSAKHGIIGLTRTAAKEVGGKGIRVNAICPGRISTPMLKTAENSIGLHLQPGSANYPPIALGRDGEAKEVAQLVAFLLSDESTYISGADISIDGGWRC
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses (PubMed:15240257, PubMed:16820452).  The first step of the pathway catalyzes the reaction from farnesyl diphosphate to alpha-ionylideneethane performed by the alpha-ionylideneethane synthase aba3 via a three-step reaction mechanism involving 2 neutral intermediates, beta-farnesene and allofarnesene (PubMed:30226766).  The cytochrome P450 monooxygenase aba1 might then be involved in the conversion of alpha-ionylideneethane to alpha-ionylideneacetic acid (Probable).  Alpha-ionylideneacetic acid is further converted to abscisic acid in 2 steps involving the cytochrome P450 monooxygenase aba2 and the short-chain dehydrogenase/reductase aba4, via the intermediates 1'-deoxy-ABA or 1',4'-trans-diol-ABA, depending on the order of action of these 2 enzymes (Probable).  Aba2 is responsible for the hydroxylation of carbon atom C-1' and aba4 might be involved in the oxidation of the C-4' carbon atom (PubMed:16820452).
What are the official names of this protein?
Short-chain dehydrogenase/reductase aba4, Abscisic acid biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: H4_CAEEL
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PYRE_METST
Sequence: MTDYKNKLINLLKENNVIKFGKFTLSSGRESDYYVDMKKAITEPEILDCVAHLITNEIEHDNIDKIAGPALGAVPIATATSLISKKPMLMIRKAKKTYGTSKQIEGELLENDDVVIVEDVTTTGGSLLKAINVIEDNGGNIVKAFVIVDREEGAQETFKENNIEFTPLLTISEFKKYL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RPOC2_SOYBN
Sequence: MAERANLVFHNKVIGGTAIKRLISRLIDHFGMAYTSHILDQVKTLGFRQATDTSISLGIDDLLTIPSKGWLVQDAEQQSLILEQHHHYGNVHAVEKLRQSIEIWYATSEYFRQEMNPNFRMTDPFNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIQGISVNTQNGMMPERIWIQTLIGRVLADDIYRGSRCIAVRNQDIGIGLINRFKTLQTQPISIRTPFTCRNTSWICRLCYGQSPTHGHLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEQVRAPYNGKIQFNEDLVHPTRTRHGHPAFLCYIDLYVTIESGDIIHNVTIPPKSFLLVQNNQYVKSEQVIAEIRAGTYTFNLKEKVRKHVYSDLEGEMHWSTDVYHASEFRYSNVHILPKTSHLWILSGKSYRSGSVSFSIRKDQDQMNIHYLSTGERDFCNLLASKKKVRHKLFRFNPSDKKERRISDYSIFNQIISIDHCHFTHPTIFHDTTDLLAKRRRNRLIIPFQFQSIQERDKELMLASSISIEIPINGIFRRNSILAYFDDPQYRTQSSGITKYRTIGINSIFKKEDFLIEYQGVKEFKTKYQIKVDQFFFIPEEVHILPESSSIMVRNNSIVEVDTLITLNIRSRVRGLVRLEKKKKKIELKIFSGDIYFPGEMDKISRHSAVLIPPRTVKKNSKEKKMKNWIYVQWITITKKKYFVLVRPVILYEIADRINLVKLFPQDMFQERDNLELKVINYILSGNGKSIRGISDTSIQLVRTCLVLNWDQDKKFSSIENAHASFVEISIKGLVRYFLRIDLVKSHISYIRKRNNPPGSRFILDNESDRTTINPFFSIDSREKIQQSLSKNHGTIRMLLNRNEKCRSLIILSSSNCFQIRSFNHGKYYNGIKEGINQIQRDAMIPIKNSLGPLGIAPQVAHFDFYRLITHNQISIIKNGQLDKLKETFQVFQYYFLDENERIYKPDLCSNIILNPFYLNWHFLHHNYCEKTFTIMSLGQFICENVCIVQTKNAPHLKSGQILTVQMDSVGIRSANPYLATPGATVHGHYGEILSEGDILVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISMNLEKRVDTWNGRITKILGIPWGFLIGAELTIAQSRISLVNKIQKVYRSQGVHIHNRHIEIIVRQITSKVLVSEDGMSNVFLPGELIGLLRAERAGRSLEEAICYRVLLLGITKTSLNTQSFISEASFQETARVLSKAALRGRIDWLKGLKENVVLGGMIPVGTGFKRIMNRSKQRQYNKMTSETKKKNLFEGEMRDILFHHREFFFFVSKNLCDTSQQSSI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS2_LISMH
Sequence: MLNDLYEEIKLRKEQPKEGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNDKQELIAEVSDLTYHLLVLLAEKNIPLAAIQTELKNREGKLSTTRDRKEINDL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERN1_MOUSE
Sequence: MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPVIPYAL
What is the function of this protein?
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11850408, PubMed:25164867).  In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP.  Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:25164867).  The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11850408, PubMed:25164867).  The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11850408, PubMed:25164867).  Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: GATA_RICAH
Sequence: MTELNKLTVADSIKGLKNKDFTSKELVNAHITQIEKHRNLNAYVTETFDLALKQAEAADQNYAQNQPRTLEGIPFAAKDLFCTKGIRTTACSNILKNFVPNYESSVTQNIFDKGGVMLGKTNMDEFAMGSANITSCFGNVISPWKANDDNADLVPGGSSGGSAAAVSGFMASAALGSDTGGSVRQPASFTGLVGFKPTYGRCSRYGMVSFASSLDQAGIFTRSVLDSSIMLEAMMGFDAKDSTSIKAEVPELQSAIGSSMKNIKIGVPLNLGEGGIEPDVMKIWQDTIELLKNAGAEIVDIILPHAKYGVAVYYVIAPAEASSNLSRYDGVRYGLRVERENMTLDEMYEMTRSAGFGEEVKRRIMIGTYVLSSNCMDAYYLKAQKVRRLVANDFNNAFEKVDAIVLPAAPTEAFKIAEKQNDPTIMYLNDLFTIPASLAGLPCASIPAGLSARGLPLGMQIIGKQLDEYNVLKVASTIESGVKHIKFEPAGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: EFP_FRATT
Sequence: MASYSTNEFKGGLKVLIDGNPMVIVENEFVKPGKGQAFNRVKLKNLLNDRVVEKTFKSGESVEAADVEELTTVYSYFDGDSYVFMHPETFEQYMVSEEALGETKKWLKDQDEYQVILFNGQPISIIAANFVNLEIIETDPGLKGDTAGTGGKPATLSTGAVVRVPLFVQTGEIIKVDTRTSTYVSRVKD
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DENR_DICDI
Sequence: MSDTESSTPSQPIVVVEYCKICSLPTEYCEYGPSAKQCLKENGPHPNNNKNTASGKDSSNTTATTTTTDTTTTTTTSTENTEEKLKDLKIVDDSKEVSHVDAGKSESKEATGEEKEKEKVSKKKKEVKPQIIIEVNQRNKRKHVTKITGLELYGIKLSDAAKVMAKKFSCGCSVVKSISNPNSEDIDIQGDFGEELVDLIEEKYPTVPLSEIYFLEDKKKVKAR
What are the official names of this protein?
Density-regulated protein homolog.
What is the protein family that this protein belongs to?
Belongs to the DENR family.
Protein: TRL33_ARATH
Sequence: MRKQESEGANLEFESKSNDNGNVKIAPNDQSFLTILDDIKSSKSPAVINYGASWCGVCSQILPAFRKLSNSFSKLKFVYADIDECPETTRHIRYTPTFQFYRDGEKVDEMFGAGEQRLHDRLWLHS
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Thioredoxin-like 3-3.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: TSAD_ANAPZ
Sequence: MGEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLVKKAMSNSGLKFDDLSSIAVTAGPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVARMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDDSLGEAFDKVARMLGLGYPGGPAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASFQECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPPRELCTDNGIMVAWAGVENFRKGNAVASLGFAPRARWTMESIS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPB_SHESM
Sequence: MTPQLILASTSVFRQALLQKLGLAFGSCNPDIDESPMTNESAQDLVLRLAKAKAKAGATHFPHGLIIGSDQVAVIDGKIIGKPLNRENAIKQLSQASGKVITFYTGLALYDAKTGEVTAQVEPFTVHFRQLTAAQIVAYVDKEQPFYCAGSFKSEGLGIALFTRLEGRDPNTLIGLPLILLTEMLLNHGIDVLAD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_HALWD
Sequence: MSAPNQNTLWARTFVSELAASGVDTVCISPGSRSTPLTVAFDRHDSIETFSHLDERSAAYFALGRARRTGSVTPVVCTSGTAAANYHPAVIEASQARVPLLVLTADRPPELHDSGANQTVDQTKLYGDAVRWFHDIGEPEPTARKLRSLRTTAARSIMTATDTPAGPVHLNFPFRKPLEPTPVPGDIPDDLSEESITGRDGAFVESTTGNRVLDENSVNRIAQSLSTSRGLIVVGPMTIPGVDPEAVAAFAHASGFPVLADPLSGIRYGGLTRTTPIIGGYDGYLTSELWDQWPDPDVVLRFGASPTSKPLRQYLESTSPTQYLVDPAGEWREATFTATDIVVADPTQLLWQLSRALNTPGSSTWRQRWIEADKAHTDVLANTDSSAHQSLAATNSDSSTDDIIENTDEEGSNESDRWFCEGRILSDVMTAAPDPATIFVSNSMPVRDLDRFGSPTTQNRTVLGNRGASGIDGIISTALGAGSALATTEHLIAITGDLAYYHDMNGLAALERCDVTATIVLINNDGGGIFHKLPIESYDPPFTTQFVTPHGLDFEPTEDIYDLSFARVRGTDRDGFHTAFTEATTTTGSHVIEVVTDSESSHRVREQLHDRVIKRILDN
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SSRP_PROMA
Sequence: MSKARNNKKSKLSKAKSNRRLAENRYARHQYEILEDIEAGIELLGTEVKSIRAGNVNLRDGFCLIREGSLLLHNVHISPFNNAGSFFNHEPLRVRKLLAHRKEINKLETQVNRKGLTLVPLNIFLKGSWIKITIGLGKGRKLHDKRENEKRKQSEREVKSALARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ILVC_DELAS
Sequence: MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNESGVKVVVGLRKGGASWDKVAKAGLTVAEVDDAVKSADLVMILLPDENIPEVYNNNVAPNIKQGATLAFAHGFNIHYNQVVPRADLDVIMVAPKGPGHTVRSEYLKGGGVPSLIAVYQDKSGKARDLALSYAMANGGGKGGIIETNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGTEVINDKSREAMRAALKRIQTGEYAKMFIQEGRTNYPSMTARRRMNADHAIEKVGGQLRAMMPWISKNKLVDQSRN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PYRI_PYRCJ
Sequence: MSKELIVSKIENGTVIDHIPAGRALMVLRVLGITGREGLRIALVMNVDSRKLGKKDIVKIEGRELTPEEVNIISAVAPTATINIVKNFEVIKKFKVSPPEVIRGRFKCRNPMCITNAPREPVVPTFYLVKREPPLFVCAYCGRYHELSDLI
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: ERF1_DICDI
Sequence: MSAVDDQQNADKQVEQWKIKKLIKNLEAARGNGTSMISLIIRPGDQIAKVNKMLAEEYGTASNIKSRVNRLSVLGAITSAQQRLKLYTKVPDNGLVIYCGTMVTDEGKEKPVRIDIEPFKPINTSLYLCDNKFHTAPLGELLESDEKFGFIVVDGNGALFGLLCGSTRTVLHKITVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVSELATQFYVTNDKPNVSGLILAGSADFKTELGTSDMFDQRLREKIIKIVDVSYGGDNGFNQAIELSGEVLSSVKFIQEKKLISQFFEEIAQDTGKYCFGIADTLKALDLGAAHTLIVWESLETIRYLLRLPTGEEKVIFLNKDQNKDASVFKDKESGLDYEIVEEMPIVEWFANNYKNFGASLEFVTNKSQEGSQFCKGFGGLGGLLRYQVDFAQLNDFDNPDENEYDDSDSDF
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA2_BACSU
Sequence: MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDVVSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_MYCUA
Sequence: MAHKKGASSSRNGRDSAAHRLGVKRFGGQVVKAGEILVRQRGTKFHPGVNVGRGGDDTLFAKAAGAVEFGIKRGRKTINIVEPATQDA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SLMA_VIBCH
Sequence: MAGNKKINRREEILQALAEMLESNEGASRITTAKLAKQVGVSEAALYRHFPSKARMFEGLIEFIEESLMSRINRIFDEEKDTLNRIRLVMQLLLAFAERNPGLTRILSGHALMFENERLRDRINQLFERIETSLRQILRERKLREGKSFPVDENILAAQLLGQVEGSLNRFVRSDFKYLPTANFDEYWALLSAQIK
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HCMA_AQUTE
Sequence: MTWLEPQIKSQLQSERKDWEANEVGAFLKKAPERKEQFHTIGDFPVQRTYTAADIADTPLEDIGLPGRYPFTRGPYPTMYRSRTWTMRQIAGFGTGEDTNKRFKYLIAQGQTGISTDFDMPTLMGYDSDHPMSDGEVGREGVAIDTLADMEALLADIDLEKISVSFTINPSAWILLAMYVALGEKRGYDLNKLSGTVQADILKEYMAQKEYIYPIAPSVRIVRDIITYSAKNLKRYNPINISGYHISEAGSSPLQEAAFTLANLITYVNEVTKTGMHVDEFAPRLAFFFVSQGDFFEEVAKFRALRRCYAKIMKERFGARNPESMRLRFHCQTAAATLTKPQYMVNVVRTSLQALSAVLGGAQSLHTNGYDEAFAIPTEDAMKMALRTQQIIAEESGVADVIDPLGGSYYVEALTTEYEKKIFEILEEVEKRGGTIKLIEQGWFQKQIADFAYETALRKQSGQKPVIGVNRFVENEEDVKIEIHPYDNTTAERQISRTRRVRAERDEAKVQAMLDQLVAVAKDESQNLMPLTIELVKAGATMGDIVEKLKGIWGTYRETPVF
What is the function of this protein?
Together with HcmB, catalyzes the isomerization of 2-hydroxyisobutyryl-CoA and 3-hydroxybutyryl-CoA.  Is specific for 2-hydroxyisobutyryl-CoA and (S)-3-hydroxybutyryl-CoA, and shows only very low activity with (R)-3-hydroxybutyryl-CoA, isobutyryl-CoA and butyryl-CoA (PubMed:22433853, PubMed:25720495).  In vitro, can isomerize pivalyl-CoA and isovaleryl-CoA, with much lower efficiency (PubMed:25720495).  Plays a central role in the degradation of substrates bearing a tert-butyl moiety, such as the fuel oxygenate methyl tert-butyl ether (MTBE) and its metabolites (PubMed:22433853).
What are the official names of this protein?
2-hydroxyisobutanoyl-CoA mutase large subunit, 2-hydroxyisobutyryl-CoA mutase large subunit, HCM large subunit.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA mutase large subunit family.
Protein: DRB2_ARATH
Sequence: MYKNQLQELAQRSCFNLPSYTCIREGPDHAPRFKATVNFNGEIFESPQYCSTLRQAEHSAAEVALNALSNRGPSHSLAARILDETGVYKNLLQEIAQRVGAPLPRYTTFRSGLGHQPVFTGTVELAGITFTGDPAKNKKQAEKNAAMAAWSSLKQLAKETSSSMPEPENIDELEQVIIARALINYRIKENIGTGSSSSAPVPFAKKFFMQNLRPTSPQPSPATTSRILPFICPKQPSRSSRSSLAATSGIDRIMAAALESRSYQRPQQRFANPPYVPMRQFRSQCHGMAPPVTIRTAVPVFSAPPMPPPPCTNNTQLPSSVYVPSLMRTAPPVRIAPPVTIRTAVPVFASAPPVRIRTAVKPTVEAGETRISSVQEKESIPVLPDSLEIGVEGSTITITDCEKTASKETERAEFKDSSKGEPETARERLENLKI
What is the function of this protein?
Binds double-stranded RNA.  May be involved in RNA-mediated silencing.
What are the official names of this protein?
Double-stranded RNA-binding protein 2, dsRNA-binding protein 2, AtDRB2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_PSEPW
Sequence: MKAFTQHTGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPYQDNSKRPLNQEFVLNHERYQGASVLLARENFGCGSSREHAPWALDEYGFRSVIAPSFADIFFNNSFKNGLLPIILSDEEVEELFKQVEANPGYQLTIDLQAQAVTRPDGKVLHFEIDAFRKHCLLNGLDDIGLTLQDGEAIKAFEGKHRAAQPWLFRDA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RS13_WOLPM
Sequence: MARIAGINIPVRKCVPFALTYIYGIGIATANVICHACEVDKRKRVSELRDEDIEKISGFIRQNYVIEGELRKEVAMNIKSLVEMGCYRGVRHRKGLPVRGQRTHTNAKTRKGRSRLPIAGKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.