PharMolix/UniProtQA huggingface dataset:
Protein: MTLD_STRPI
Sequence: MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVIQVTGLDDQELIEQIVEYI
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: ZCH18_DANRE
Sequence: MDTPESPTQSPQSPEEEEKGLSDNELLESPESPAEADKGVSDSELLNDDENEVPEHGGDSDSEDRDRQPAGREDPEELSDVEDYKLDREEREDIHQQEGALRVQEIAQKAIKSPEEEILETPRSPDPVSPAAEHERPFTPAEEERGDDDEEEEEDETTTKSGLGQAELEEEEDEEEERRRRRRAAMVVSDLKDESSVSRDLDEHELDYDEEVPEEPSAAAPEEDEPEKPAVGEDGEDEEEEDEEEEKRRKRKERKPILPPDNRDTPLRKSEDSREGGRRDSFRDKKKEEDDGEIDEGEIDDDDLEEGEVKDPMDRKIRPRPICRFFMKGSFVTMYGNVKFFFFKSYLVFLTGNCTWGMICRFIHPGVNDKGNYSLISKPDPFSPNGAPPGGAAGGGPHPLMPANPWGAPAVEELPPPPPPLDPPVESAWERGLRHAKEVLKKATIRKEQEPDFEEKRFTVTIGEDDRDFDKENDFFRERGGYRITREIRDAGSDPYGDPYYDYEMEAFWRGGQYENFRVQYTETPLPYYPDRERERDPRERHRERERERERDHRERERRQREREREREREREKDSRRRKDEWDRDRLKRDEKEGRPRERPLREPREKKDEKEKTLKPRSPTNMPPRGPMEPPTKKDMLSVTKRPDEWNDPWCRSKSPRRRPGFMGSPPRGRRRHRPSGSSVSLSNSSRSSSRSSSFTGSGSSRSRSRSRSSSMSSYSSHSSQHSSFSGSRSRSGSFSSSPSPSPSAQRNANKNKAEQPPAAAKGPPLKPGALPPPRRDKGPPKVMPSPSLPEQPGKPPKPITETVKPPNPRPPGRPPGPREPREPPNMREGRKKERQQHNPPRRRTVSGSVSGSSYSGSSSRSRSRSSSASASRSGSHKSRSLSVSSVSSVSSASSSSSSVRSADSDDMYADLASPVSSASSRSPTPGHPRKDRGPPRERGPNKERGKPPKKDEPFKDERKRVDPSGLPSKASSDMPRSGNRGHPMHPPPMGPPGGYGSHKDIKLTLLNKQQTDRSNRKRYFPSDKERPPSPLRKRMAMSPDGGRDRRMPGRPPMSPRMERPKGQGPRPMPSQGERKRPLSPPAKSSGKGPAAASAAKPPAPGAGSGSASGSAPGKPSSTLSRREELLKQLKAVEDAIARKRAKIPGK
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 18.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECR_PSESM
Sequence: MSFSPLIRQLIDAFRVLPGVGQKTAQRMALQLLERDRSGGSRLALALGQAMDGVGHCRLCRTLTEEELCPQCSDLRRNDTLLCVVEGPTDVYAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPQLMERISQQATFTEVILATNPTVEGEATAHYIAQLLHDKGLVASRIAHGVPLGGELDLVDGGTLAHSFAGRKPIAL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: CSTN3_HUMAN
Sequence: MTLLLLPLLLASLLASCSCNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGKKEEETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEEKNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSISHQVEAKKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLELTNTSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAATLIIVVCVGFLVLMVVLGLVRIHSLHRRVSGAGGPPGASSDPKDPDLFWDDSALTIIVNPMESYQNRQSCVTGAVGGQQEDEDSSDSEVADSPSSDERRIIETPPHRY
What is the function of this protein?
Adipose-specific isoform that plays a key role in adaptive thermogenesis.  Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization.  May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons.
What are the official names of this protein?
Calsyntenin-3, Alcadein-beta, Alc-beta.
What is the protein family that this protein belongs to?
Belongs to the calsyntenin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Postsynapse. Cell projection, dendrite. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.
Protein: GAJA_BACC6
Sequence: MKFSNITIKNFRNFEKVNINLDNKNVIFGMNDIGKTNFLYALRFLLDKEIRKFGFNKSDYHKHDTSKKIEIILTLDLSNYEKDEDTKKLISVVKGARTSANADVFYIALESKYDDKELYGNIILKWGSELDNLIDIPGRGNINALDNVFKVIYINPLVDLDKLFAQNKKYIFEESQGNESDEGILNNIKSLTDQVNQQIGEMTIIKGFQQEITSEYRSLKKEEVSIELKSEMAIKGFFSDIIPYIKKDGDSNYYPTSGDGRRKMLSYSIYNYLAKKKYEDKIVIYLIEEPEISLHRSMQIALSKQLFEQSTYKYFFLSTHSPELLYEMDNTRLIRVHSTEKVVCSSHMYNVEEAYGSVKKKLNKALSSALFAERVLLIEGPSEKILFEKVLDEVEPEYELNGGFLLEVGGTYFNHYVCTLNDLGITHIIKTDNDLKSKKGKKGVYELLGLNRCLNLLGRENLDEITIDIPEDIKGKKKKERLNERKKEIFKQYKNEVGEFLGERIYLSEIDLENDLYSAIGESMKRIFENEDPVHYLQKSKLFNMVELVNNLSTKDCFDVFEHEKFACLKELVGSDRG
What is the function of this protein?
Component of antiviral defense system Gabija type I, composed of GajA and GajB.  Expression of Gabija type I in B. subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14, SpBeta and SBSphiC (PubMed:29371424).  An endonuclease that nicks double-stranded DNA within the sequence 5'-TNNNCGGGNNA-3' in the absence of nucleotides (NTP, dNTP and NDPs), cleaving after C-1.  Has no detected ATPase activity.  Expression of Gabija type I in E. coli B (strain ATCC 11303) confers resistance to phage T7 (PubMed:33885789).  It is thought that this enzyme is strongly suppressed during physiological growth (in E. coli total nucleotide concentration is over 8. 7 mM in mid-log phase), but during viral replication, when nucleotides are rapidly consumed, it is de-suppressed and degrades target DNA (Probable).
What are the official names of this protein?
Endonuclease GajA, Gabija protein GajA, Nicking endonuclease GajA.
Protein: RK27_ARATH
Sequence: MAMATSMSLNLIGAFKGLSLSSTSSFLRGDLSFSPKTSFTVTLPLENLQAPIPLTIESAHKKGAGSTKNGRDSPGQRLGVKIYGDQVAKPGAIIVRQRGTKFHAGKNVGIGKDHTIFSLIDGLVKFEKFGPDRKKISVYPREIVPENPNSYRARKRENFRLQREKKKARRENYSYTLPTPELVLASASVDDAEANPEC
What are the official names of this protein?
50S ribosomal protein L27, chloroplastic, CL27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RK16_PORPU
Sequence: MLSPKKTKFRKQHRGRMKGSASKGNTIAFGDYALQATEPVWLTSRQIEATRRTITRYVRRGGKLWIRVFPDKPVTARPAETRMGSGKGAPEYWVAVIKPGHILFEITGVPQKTAQQAMKLASYKLPIKTKFIVRNTIES
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y997_STAEQ
Sequence: MVKNYSFYQFIMTVRGRKDDKGVFAEQIFEDLAFPKHEDDFNTLSEYIETHSEFTLPMSVFDDLYDDYTEWLKF
What are the official names of this protein?
UPF0346 protein SERP0997.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: RL22_CLOPP
Sequence: MKVKAVASQIPVTPRKVCLVVDLIRGQKIKEAEAILTLNSKSAAPIVLKLLKSAVANAVNNFNLNKDDLYVEEIFVNES
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: KAD_PSEPK
Sequence: MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTPLGLELKKVMDAGQLVSDELIISLVKERIAQPDCANGCLFDGFPRTIPQAEAMVAAGVDIDAVVEIAVDDEEIVGRMAGRRVHLASGRTYHIQYNPPKVEGKDDETGEDLIQRDDDKEETVRHRLSVYHSQTKPLVDFYQKLSAANGGKPKYSHIEGVGSVEAITAKVLAALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_MYCBO
Sequence: MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAYNAATENQRGNVIPVEITVYEDRSFTFTLKTPPAAKLLLKAAGVAKGSAEPHKTKVAKVTWDQVREIAETKKTDLNANDVDAAAKIIAGTARSMGITVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SYP_ACIC5
Sequence: MHRWSRLFVPTLREAPSDAEVASHKFLLRSGYIRQLGAGIYSYLLFGQRSINKIVGIVREEMDKIGQEFLLPAIHPADLWRESGRWTVMGDNMFRLKDRKGAELCLGMTHEEVMTDIARNELRSYKQLPQIWYQIQNKFRDEPRPRSGLLRVRQFLMKDSYSFDLNQAGLDKSYDLHDAAYRAIFTRCGLNFVVVEADSGAMGGSGSQEFMVYTDAGEDLIASCAKCGYAANMEKATSKLAPVEELAATGDGQPELISTPGQAAIADICKFLGMQPHSDIKCVAYMAEVPSEDGKTSTWEPVAAFLRGDHFVNETKLLAVVGATELRPMQAEELEKWMHGPAGYLGPVGLTPAKKLRDGSLNVVLDLGLEGRRNLVAGANKLDYHYRNVTPGRDFTWTVAADIRNAAEGEGCPVCGEPLKVAKAVEIGHIFKLGTKYTESMGARVLDENGKEVMPVMGCYGIGIERILTASIEQNNDANGFWLPRSIAPFDVVVTITNMADETLRQAGEALAAQLEAAGYDVLLDDREERAGVKFKDADLVGIPYRFNVGKKTLEGKTELVTRATASSQDVALDAAVEALKALTA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KNAP1_MALDO
Sequence: MEDYNNQMDHESSGGRGNFLYASPNLGGNYGRAASDHQMGINTFHLQSSGGGGGGGSGDQCNFQSPGTHPINVKTEATTSQHGHPKFQYNNNNNNHHLVSSSRGHQPVVHQLQHNLDLQNDDHSLSSNEVEAIKAKIIAHPQYSNLVEAYMDCQRVGAPSDVVPRLSVARQEFEARQRSSGTSRETSKDPELDQFMEAYYDMLVKYREELTRPIQEAMDFMRRIETQLNMLGNNNNAPPLRIFSPSEDKCEGIGSSEDEQENSGGETEVPEIDPRAEDRELKNHLLRKYSGYLSSLKQELSKKKKKGKLPKEARQKLLSWWELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPSEDMQFMVMDGLHPQNAALYMDGHYTGDVHYRLGP
What is the function of this protein?
Probably binds to the DNA sequence 5'-TGAC-3'.
What are the official names of this protein?
Homeobox protein knotted-1-like 1, KNAP1.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL11_NITMU
Sequence: MAKKIVGYIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAATQKMEVGLPVPVVITAYADKSFTFTMKTTPATVLIKKAAGVGKGSAKPHTDKIGRLTRKQMEEIAQIKMPDLTAADMDAAVRTIAGSARSMGIEVEGA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PSBI_PAUCH
Sequence: MLALKISVYSVVFFFIGIFVFGFLASDPSRTPSRKDLED
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, organellar chromatophore thylakoid membrane; Single-pass membrane protein.
Protein: NMD3_PONAB
Sequence: MEYMTESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTVQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYHLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSAIHLIDPNTLQVADIDGSTFWSHPFNSLCHPKQLEEFIVMECSIVRDIKRAAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEGASMMT
What is the function of this protein?
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal export protein NMD3.
What is the protein family that this protein belongs to?
Belongs to the NMD3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.
Protein: PYRG_NITWN
Sequence: MARYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNLDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGRPATRQDNITTGRIYQDILTRERRGDYLGATIQVIPHVTNAIKAFILDGNDDHDFVLCEIGGTVGDIEGLPFFEAIRQLKNDLPRGHAIYVHLTLLPFIPSAGELKTKPTQHSVKELRSIGIQPDILLCRTDREIPAEERRKLGLFCNVRESAVIEARDADNIYAVPEVYHAAGLDDEVLAAFGIEPAAPPALKGWHDINERIRNPEGAVTIAIVGKYTGMKDAYKSLIEALSHGGIANKVKVNLDWIESEVFENEDAAPFLEHVDGILVPGGFGQRGAEGKIKAARFARERHVPYFGICFGMQMAVIEAARNLVGISDANSTEFGPTREPLVGLMTEWLRGSELEKRSKAGDLGGTMRLGAYPAMLKRGSRVSGIYGGAVEISERHRHRYEVNTAYKDRLEQHGLRFSGLSPDGVLPEIVEYQDHPWFIGVQYHPELKSRPFEPHPLFASFIQAAVVQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: S100B_MOUSE
Sequence: MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVAMVTTACHEFFEHE
What is the function of this protein?
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (By similarity).  Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (By similarity).  Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity).  Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (PubMed:2592414, PubMed:8202493).  Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (PubMed:31043739).  Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity).  Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity).  Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).  May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
What are the official names of this protein?
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL14_CALS4
Sequence: MIRPQTRLKVADNTGAKEIMCIRLLGGSNRKYSNVGDIIVASVKSATPGGVVKKGEVVKAVIVRTKKGIARKDGTYIRFDDNAAVIIRDDKQPRGTRIFGPVARELRDKDFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RS16_NITEC
Sequence: MVVVRLARGGAKKRPFYNMVVADSRRHRDGKFIERVGFYNPRATGGEESLRIQMDRLNHWQSQGAQLSSTVSRLVKQFGRQQKPA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: TYSY_STAA2
Sequence: MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN451_HUMAN
Sequence: MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPLRPVLEYIDLVSSDDEEPSTSYTDENIKRKDHIDYQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINCGTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQQYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDETSTQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAHLNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANSSPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLIFNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGKLWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGSEKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM
What is the function of this protein?
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494).  Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro).  Required for MCM4 sumoylation (By similarity).  Has no activity with SUMO1 (PubMed:26524493).  Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493).  Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling.  Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267).  Plays a role in regulating the transcription of AR targets (PubMed:18656483).
What are the official names of this protein?
E3 SUMO-protein ligase ZNF451, Coactivator for steroid receptors, E3 SUMO-protein transferase ZNF451, Zinc finger protein 451.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location.
Protein: LSRR_ECO24
Sequence: MTINDSAISEQGMCEEEQVARIAWFYYHDGLTQSEISDRLGLTRLKVSRLLEKGHQSGIIRVQINSRFEGCLEYETQLRRQFSLQHVRVIPGLADADVGGRLGIGAAHMLMSLLQPQQMLAIGFGEATMNTLQRLSGFISSQQIRLVTLSGGVGSYMTGIGQLNAACSVNIIPAPLRASSADIARTLKNENCVKDVLLAAQAADVAIVGIGAVSQQDDATIIRSGYISQGEQLMIGRKGAVGDILGYFFDAKGDVVTDIKIHNELIGLPLSSLKTIPVRVGVAGGENKAEAIAAAMKGGYINALVTDQDTAAAILRS
What is the function of this protein?
Regulates transcription of many different genes.  In the absence of autoinducer 2 (AI-2), represses transcription of the lsr operon and its own transcription.  In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes (By similarity).
What are the official names of this protein?
Transcriptional regulator LsrR.
What is the protein family that this protein belongs to?
Belongs to the SorC transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_STAA2
Sequence: MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPR_BACSU
Sequence: MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDFMEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS
What is the function of this protein?
Negative regulator of protease production and sporulation.  Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation.  Acts with SinR as a corepressor of epr expression.  Binds to non-m6A-5-methylated 5'-GACGAG-3' sites, tested with scpA; when the target is methylated by DnmA, this repressor no longer binds and transcription is up-regulated (PubMed:32324221).
What are the official names of this protein?
DNA-binding transcriptional repressor ScoC, HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.