PharMolix/UniProtQA huggingface dataset:
Protein: TRUA_RHILW
Sequence: MPRFRMTVEYDGGPYVGWQRQENGPSVQGAIEAAVLSLTGETVSIRGAGRTDSGVHAMGQVIHADLSKAWSPYQLQNALNAHLRLAGERVSILDVEAVAEFFDARFSALRRHYLYRIVSRRAPLALEAGKAWWVPKVLDHEVMHAAAQRLVGRHDFSTFRAAHCQANSPVRTLDRLDVTRSGELIEIRATAQSFLHNQIRSFAGTLKLAGEGKWTPDDVEAALEARDRKACGPVAPPDGLYFLQVDYPDVIPDRRRPVTDADDGDNLS
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SOT6_ARATH
Sequence: MDEKKITMNVRNDELSEESKTLISSLPSDKNSTGVNVCKYQGCWYTPPILQGVLNFQKNFKPQDTDIIVASFPKCGTTWLKALTFALVRRSKHPSHDDHHPLLSDNPHVLSPSLEMYLYLCSENPDLTKFSSSSRLFSTHMPSHTLQEGLKGSTCKIVYMSRNVKDTLVSYWHFFCKKQTDDNIISSVEDTFEMFCRGVNFFGPFWDHVLSYWRGSLEDPNHVLFMKFEEMKEEPREQIKRLAEFLGCLFTKEEEESGLVDEIIDLCSLRNLSSLEINKTGKLHSTGRENKTFFRKGEVGDWKNYLTPEMENKIDMIIQEKLQNSGLKF
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor.
What are the official names of this protein?
Cytosolic sulfotransferase 6, AtSOT6, sulfotransferase 3b, AtST3b.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEM3B_HUMAN
Sequence: MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPLESRRKGRNRRTHAPEPRAERGPRSATHW
What is the function of this protein?
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
What are the official names of this protein?
Semaphorin-3B, Sema A(V), Semaphorin-V, Sema V.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
Protein: PPE22_MYCTU
Sequence: MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYAEMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPNTLLGLTSPLSSALTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEAAAAAPAAVGAAVGGTGPVSAGLGNAATIGKLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGNLLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG
What are the official names of this protein?
Uncharacterized PPE family protein PPE22.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: PYIT_MAGGR
Sequence: MEKAKDSLPTTGDPVPSQGTINPVDETGGSASDEKKAKKGCDFWFTFSSLVLTAFLSALEGSVVSTALPTIARALEASENYVWVVNVYYLSKYETWLTYLLRFSSAAFQPIYGQLADLWGRRWLTIGAVVIFTVGSGICGGATSIDMLIGGRAIQGLGSAGINMLVELILCDLLPLRERGQFFGIIFMFVILGSVIGPFLGGILVDRVSWRWVFYINIPFSGVCVVLLFFFLHIKNAGTGNFIDKVKRIDFFGNFLLAASVGSCLFALTYGDTRYPFSDTRIIVSLVLGLLGHVAFMFFEASPWCKEPVMPMVLFKNRTSAGAYIATFLQTLVSFWVLYFLPLYFQSTQLVSATRSGVMLLPFSVVYALSSLAGGALTTKLGRFRNIHFASFALMTIGMGTLTILNRSTSLAVIVVLEMIVALAIGVPTANLLTAIQAALPDELNALSTGTFAFLRSVGTIWGVSIPAAIFNNRFDQLLPELSDPTAVRALQRGGAYQQATSEFVDSFPSDVRDVIISIYERSLERVWQIGIVFAGVGFLVIFLERDLKLGTQKKTEDIEINDIPQTAADNSASRPNTINDTASQAPILKQRRSTNQERETV
What is the function of this protein?
MFS-type efflux transporter; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology (PubMed:31099577) (Probable).  Pyrichalasin H is indicated as the responsible agent for the genus-specific pathogenicity of M. grisea toward crabgrass (PubMed:31099577).  PyiT might be involved in the excretion of pyrichalasin H (Probable).
What are the official names of this protein?
MFS-type efflux transporter pyiT, Pyrichalasin H biosynthesis cluster protein T.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FBID_MYCRK
Sequence: MRCNGMSPVSVAQRNTGIWAVVPLKAPECAKTRLSGVLSHAARQALFFSMASHVIGTLRASPRIASLLVVTPSESTAEMARAAGAEILWGPPDEGMANACSRAMAHIAAAGGERVMFVPGDLPLLDGAAIDMLSRAPVDAIGMAPNRDGHGTNGLICRPGAIPLFFSGPSFSAHQNAARCAGIDVWIVRSREWALDVDLPADLEEFESSIKDAKRRVLCQI
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2R)-3-phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP.  It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420.  Can also use (2S)-2-phospholactate (2-PL), with lower turnover, and has weak activity with phosphoenolpyruvate (PEP).
What are the official names of this protein?
3-phospho-D-glycerate guanylyltransferase, 3PG guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: CRR14_ARATH
Sequence: MSSFCLSKHLILVPILVMMAQLLLIRNVLSLNMNNPYLYHKCSANQGEYKLGSLYKKSLDSGIQQLSKDNEVFRGGFVYMDHTDPNGTLRVYITFQCRGDIYGSHCRSCFATARAELFKRCPRDKAAIIWYDQCFLEFSSISTGGKINYDDNICIDTARARPNAKTHTGDDSVLEFLRLFENLTNIAVTKRNNFVKDVEKPALYAAGEKRFGNKKIYVMVQCTHDLTPRACVECVNHNVRQFQDCYEDKPVGLKKGARVLGRSCNFRFERYPFVNAKTSPNYLKF
What are the official names of this protein?
Putative cysteine-rich repeat secretory protein 14.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: BAT45_CAEEL
Sequence: MAAAHKVFELSHVFKDVSKIGDDESVCSPNEDYFGVPWKIVLRHKDEKMGVFLSCEKPSNNDAHCIVNVVYSVKLMSSSGVCYIKSDSKLFGEITEHGWVNFVNWNTMVDAFLIDDSIIIEVLVKTIFMSGLPKKSPKNFDESNKEFSDGIVVVKHQNFHILKKFLAFHCEYLEKLFFGDFKEAGKAEVTLKAISSTDFHYLLAVLYEDYAIDDDNVGGILRLASYLQVPIVIRKCEQFLIEGSGKPMEIRLDIAEKECLQNLKKHCLSKVGTADQIEAARAILPSDIPKRALKKFDESNKEFSDVIFVVEHNKFYVLKQILASHSSHFKKIFVENVDKREFTLADIDSNDFQNLVEVMYGVSFIDDLTVEGVLHLAHMYDRPFPMQKCVEFLIDLSEKSPKEKLKIAKAYQLKNLEKAALARINLPESIRAALSCDMAQMEVEVLKALMQKALFHLSDTKVHTETFF
What are the official names of this protein?
BTB and MATH domain-containing protein 45.
Protein: LACA_STRPJ
Sequence: MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLAVAAEVNKEEQNLGIVIDAYGAGSFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: PCP_ALECO
Sequence: DEIGDAAKKLGDASYAFAKEVDCNNGIFLQAPGKFQPLEALKXIXKHXV
What is the function of this protein?
Water-soluble antenna for capture of solar energy in the blue-green range.  Peridinin is an asymmetric carotenoid.
What are the official names of this protein?
Peridinin-chlorophyll a-binding protein, PCP.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: XYLA_RHOBA
Sequence: MTAFPDVPVIQYEGPQSDNPLAFRWYNPDEVIEGKTMKDHMRFSIVYWHTFRGTGADPFGPGTAVRPWDNGSESVENAQKRAVVAFELFTKLQAPYYAWHDRDVAPEGANLRETHANLDAVADVLEEQQKATGVKLLWGTANMFSNPRFMHGAATSCNADVFAYAGAQVKKALEVTKRLGGENYVFWGGREGYQNLYNTDMKRELDHLAKFFHMAVDYAKSIGFDGQFLIEPKPKEPTKHQYDSDAAACMNFLRAYDLDSHFKLNIETNHATLAGHTMMHELDYAGIQGGLGSIDANTGDLLLGWDTDQFPTDYYLTTQTMLMILKHGGIGTGGVNFDAKVRRESFEPIDLFHAHIGGMDAFAKGLKIAAAIRASGELADFVKNRYSTWDSGIGAKIEAGEVGFAELEAYMLEKGDVDANQSGRQEYLEHMINKYIDRV
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MG_HUMAN
Sequence: MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
What is the function of this protein?
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
What are the official names of this protein?
DNA-3-methyladenine glycosylase, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, ADPG, N-methylpurine-DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.
Protein: PDXS_PYRAB
Sequence: MDKLKIIMEKGTERLKRGFAKMVKGGVIMDVTNAEQARIAEEAGAVAVMALHKVPADIRKAGGVARMAPVEKIQEIMDAVTIPVMAKCRIGHEAEARILEALGVDMIDESEVLTPADPFFHIYKKKFTAPFVCGARNLGEAVRRIWEGAAMIRTKGEAGTGNIVEAVRHVRLVNENIRLIQRMTDEEIYGVAEKFAEPYLRLAFSVKEISGLPKRVLENEPIYEGFTYREIVEGIYKILLEIKKLGRLPVVNFAAGGVATPADAALMMAMGMDGVFVGSGIFKSSNPPKMARAIVEAVNHWDEPDVLAEISREIGEPMRGQAIEELQVRMEERGV
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: ACEK_PSEA6
Sequence: MNNTHSSVLNKVAYLILHGFDKSYRWHSRITRDAQQRFEQALWQETQKAVKERIAIYERTLADAVGEIYQQVFPHQENNQFWFDLKTRYQKILSDHPQYELAETFYNSVLGRIFKHQKINDEMMFIMPTRCYLAGLQRHLVVHSFDTSGTVRRMLEDIFSQYHFDIAFQDMQRDLQHLDGALRARLNREQLASVHTVEMLKPVFYRSKSAYLIGRICMPDETLPFVIPLSIAEAETSGEKHKIVVEALLTERQDLSVVFSFARAYFMADTQHPAEVVAFLHELLPHKKKFELYIALGLYKHGKTVFYRNFLAHLEESNDQFSIAPGIRGLVMAVFHLPSYGVVFKIIKDEFPESKKITRQHVKDCYKLVKMTDRVGRMADTHEYVNFRLPRHRVEQALVDELLDCCASSIELTDEEVIIKHLYIERKMTPLNIFLEQQPDPALITSALNDLGLCIKQIAAAHIFAGDMLHKNFGITRGGRVIFYDYDEICYLTEREFRTLPKSDDPYAIDTLSVGPTDVFPEQFEHFIVGKKHLKQELKALHGEIMTAEYWQHMQAQSLKGDVPDFIPYNQAKRFVN
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_FUSNN
Sequence: MEKIGNDYHIPVLYYETLDNLVINPDGTYIDCTLGGGSHSEGILERLSDKGLLISIDQDTNAIEYSKKRLEKFGSKWKVFKGNFENIDTIAYMAGVDKVDGILMDIGVSSKQLDDPDRGFSYRYDVKLDMRMNTDQKISAYDVVNTYSEEQLSKIIFEYGEERHARKIAKLIVEERKSSPIEKTSDLITLIKRAYPERASKHPAKKTFQAIRIEVNRELEVLENAMSKAVELLKVGGRLAIITFHSLEDRIVKNKFKDLATACKCPKDIPICVCGGVKKFEIITKKPIIPIDDELKNNNRAHSSKLRILERIFD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_XYLF2
Sequence: MSIGKNVARLRRAKSTRLHIRKLGVPRLSVLRTGRHLYAQIFTADGSKVIAAANTLQSQVKGGLKNGKNSLAAIKVGKLIAERARAVGVDRIAFDRSGYLYHGRIKILADAARDAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: BETI_BURO0
Sequence: MPKVGMREIRRAQLIDATLRSIDEAGLPGTTLASVAQRANISTGIVSHYFGDKDGLLEATMRHVLRDLWSATTRRRVAARKDPRSRLRAVVAANFDDTQVSAPVMKTWLAFWSQSMHDPMLKRLQHVNTRRLHSNLCAEFAKALPLAKAREAASGLAALIDGLWLRGALAGGPIDTRAALKLAHDYIDLLLASD
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: VP40_EBORR
Sequence: MRRGVLPTAPPAYNDIAYPMSILPTRPSVIVNETKSDVLAVPGADVPSNSMRPVADDNIDHSSHTPSGVASAFILEATVNVISGTKVLMKQIPIWLPLGVADQKIYSFDSTTAAIMLASYTVTHFGKISNPLVRVNRLGPGIPDHPLRLLRLGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATWTDETPAGAVNALRPGLSLHPKLRPILLPGKTGKKGHASDLTSPDKIQTIMNAIPDLKIVPIDPTKNIVGIEVPELLVQRLTGKKPQPKNGQPIIPVLLPKYVGLDPISPGDLTMVITQDCDSCHSPASHPYHMDKQNSYQ
What is the function of this protein?
Plays an essential role virus particle assembly and budding.  Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101.  The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding.  May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).
What are the official names of this protein?
Matrix protein VP40, Ebola VP40, eVP40, Membrane-associated protein VP40.
What is the protein family that this protein belongs to?
Belongs to the filoviridae matrix protein VP40 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Protein: THIK_ECOBW
Sequence: MPFRSNNPITRDELLSRFFPQYHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPQSAFLRQYRALSQLPACIAPKPHLYLRDWMVVDYLPGAVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRMLKRLRKAREPRPLRLSPLHMDVHAGNLVHSASGLKLIDWEYAGDGDIALELAAVWVENTEQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQTGDQQFIRLADDTWRQLLIKQ
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: TMM81_MOUSE
Sequence: MKTGAIVFILRSLLSITYLPLVLMTLDIPEELQKAVGRVIVNATGCSVTCGLGYKEETECEVGPDGVRRNCTFQRLECVTNWICGMLHFTIVHGKTFELNCLSSDILEKGQEAFRFTWRLARGIISTNDELFRPFRANSPFIGFKPAYEYNAGTYRCDVQLLKNLKFVKRLYFGLRVLPPKLVNLNFQQSLTEDQKLIDKGWEVNLDNGSKPHLPVWQRKVTSALGIGIVAGVVGGVLVSVAVFKALGGTDGSGGRTRL
What are the official names of this protein?
Transmembrane protein 81.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HEMA_CWPXG
Sequence: MARLPILLLLISLVYSTPSPQTSKKIGDDATLSCNRNNTTDYVVMSAWYKEPNSIILLAAKSDVLYFDNYTKDKISYDSPYDDLVTTITIKSLTARDAGTYVCAFFMTSTTNDTDKVDYEEYSTELIVNTDSESTIDIILSGSTHSPETSSEKPDYIDNSNCSSVFEIATPEPITDNEEDHTDVTYTSENINTVSTTSRESTTDETPEPITDKEEDHTVTDTVSYTTVSTSSGIVTTKSTTDDADLYDTYNDNDTVPPTTVGGSTTSISNYKTKDFVEIFGITALIILSAVAIFCITYYICNKRSRKYKTENKV
What is the function of this protein?
Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane.  The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation.  Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack.
What are the official names of this protein?
Protein OPG185, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG185 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single- pass type I membrane protein. Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Component of the outermost membrane of EEV.
Protein: YEBF_SALTY
Sequence: MNKRGALLSLLFLSASVSAFAASTESKSVKFPQCEGLDAAGIAASVKRDYQQNRIVRWADDQKKVGQADPVAWVNVQDVVGQNDKWTVPLTVRGKSADIHYQVIVDCKAGKAEYKPR
What are the official names of this protein?
Protein YebF.
What is the protein family that this protein belongs to?
Belongs to the YebF family.
What are the subcellular locations of this protein?
Secreted.
Protein: SLY41_YEAST
Sequence: MIQTQSTAIKRRNSVHKNLFDPSLYQIPEPPRGGFQHQKKEYSKETFSNQVFGYDITSLKKRFTQLFPSNIQGYLPEVDLRITIICSIWYVTSSISSNLSKAILRTFNHPIALTELQFLVSAVLCVGFASIVNLFRLPRLKHTKFSKALNSFPDGILPEYLDGNFRSSILHKFLVPSKLVLMTTFPMGIFQFIGHITSHKAVSMIPVSLVHSVKALSPIITVGYYKFFEHRYYNSMTYYTLLLLIFGVMTTCWSTHGSKRASDNKSGSSLIGLLFAFISMIIFVAQNIFAKNILTIRRKVGILPSSSTDDVTSKEGQPSLDKTRFSPLQVDKITILFYCSCIGFSLTLLPFLTGELMHGGSVINDLTLETVALVAIHGIAHFFQAMLAFQLIGLLSSINYSVANIMKRIVVISVALFWETKLNFFQVFGVILTIAGLYGYDKWGLSKKDGRQA
What is the function of this protein?
Able to suppress the functional loss of YPT1.  May form a channel.  Protein SLY41 is not essential for cell viability.  The SLY41 gene is a multicopy suppressor.
What are the official names of this protein?
Uncharacterized transporter SLY41.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZAPB_ECOLI
Sequence: MTMSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQNAQHQREELERENNHLKEQQNGWQERLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern.
Protein: ARPIN_MOUSE
Sequence: MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRLKTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEWDD
What is the function of this protein?
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors.  Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex.  Involved in steering cell migration by controlling its directional persistence (By similarity).
What are the official names of this protein?
Arpin, Arp2/3 inhibition protein.
What is the protein family that this protein belongs to?
Belongs to the Arpin family.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamellipodium tip.
Protein: IL23A_CAVPO
Sequence: MLGSTAVMLLLLLPWTAQTRAVSGSSNPSWTQCQQLSQKLCTLAWSAHPSVGHVEPPREEADEETTDYVPHILCGDGCDPQGLKDNSQFCLQRIYQGLVFYQNLLGSDIFTGEPPLFPDGPVSQLHASLLGLSQLLQPEVHQWEPQIPSLSPNQPWQRLLLRIKILRSFQAFVAVAARVFGHGAATLTP
What is the function of this protein?
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity.  Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4.  This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A.  In turn, participates in the early and effective intracellular bacterial clearance.  Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
What are the official names of this protein?
Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted upon association with IL12B.
Protein: HFQ_BACAC
Sequence: MKQSINIQDQFLNQLRKENTFVTLYLLNGFQLRGLIKGFDNFTVLLETEGKQQLIYKHAISTFVPQKNVSIELE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: DYL1_HUMAN
Sequence: MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
What is the function of this protein?
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules.  Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
What are the official names of this protein?
Dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, DLC8, Dynein light chain LC8-type 1, Protein inhibitor of neuronal nitric oxide synthase, PIN.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Protein: NEUO_ECOK1
Sequence: MLRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSFSVDDNGSGNVFVCGDLVNSKENKVQFNGNNNKLIIEDDVECRWLTVIFRGDNNYVRIHKNSKIKGDIVATKGSKVIIGRRTTIGAGFEVVTDKCNVTIGHDCMIARDVILRASDGHPIFDIHSKKRINWAKDIIISSYVWVGRNVSIMKGVSVGSGSVIGYGSIVTKDVPSMCAAAGNPAKIIKRNIIWARTDKAELISDDKRCSSYHAKLTQ
What is the function of this protein?
Catalyzes the O-acetylation of capsular polymeric sialic acid.  Shows high substrate specificity toward polymers of sialic acid that contains a large number of residues.
What are the official names of this protein?
Polysialic acid O-acetyltransferase, Capsule O-acetyl transferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.