Protein: VERA_PENPO
Sequence: MTPEPIAIIGTGCKFPGSASSPSRLWDLLRNPKTVASEPPSTRFDNRSFYDPDPSHPGTTNTKESYFLSEDIRLFDSAFFNISASEAEGIDPQQRLLLETVYESLEIAGQRLEALQGSSTGIFCGVMGNDWEHRVGFDDKAIPRYAATGLARNNIANRVSYFFDWHGPSLVVDTACSSSLVALHQAVTALRQGECSVAVAAGTNLLLHPNIYISTSNLQMLSPNGRGRMWDAKADGYARGEGIGALVLKCLSDAIADGDPIECVIRATGVNQDGRTMGLTMPSSKAQLALIESTYAQAGLDPKTRPEDRCQYFEAHGTGTLAGDPQEASAIYKSFFGDSSQHVSDNDPLYVGSIKTVVGHTEGTAGIAGVIKASLSIQHGTIFPNLLFDELNPELQRFTPRLKVPTETMPWPTLAPNIPRRVSVNSFGFGGTNAHAILESYDIECDENWNGIPPQISNPIVLPFLFSAASARSLGTMLSNYEEYLRSNPKIHLMDLAWTLMKRRSMLAYRVVLCAPTIEVLIIKIREELELRKINNPSTITAQPPSGQKRILGIFTGQGAQWPQMGLDLVTHTSEGRQLFEEMHQSLLSLPIELQPTFSLFDELAAAQPMSRLHEAVLSQPLCAALQIILVNFLTAVGISFETVVGHSSGEIAAAYSAGILSASDCIRVAYLRGRVAGLAGAPNGQPGAMLAVGLSFATANLLCLEPGLQGRVHVAASNSPSSVTLSGDQDAIHEVEQRLQVEGKFARMLRVDTAYHSHHMQPCAKPYLLDMDAAQVKLGLQMNTRWYSSVHDAQEINLDEHGQSLTGEYWKNNMVSPVLFSAALLAALTSDGGPPDVIVEIGPHPALKGPAQQTISDALPSAGGSEIPYIGLSNRGASGIESLANAIGLLCAHLGPNSIDLARYFSLFDHKYTPKVVRGLPAYPFDHRQRHWFETRKLKNHLHNGGLLHPLLGSLEADTADGEWRWRHYLRREELEWLDGHQIQSRTVFPATGYIAMALEAAGIFAAGQSMRLVQIQRLSIDQAITFSDESSTGIETLFRLSGLQSQGDQVTGTFNCHANIGGRLVNCASGKLLICWGNPETSMLPSQTPPAADAGAVDIKDFYQSLAKLGYNYTGAFQGITSLARQKDMSTGQIINMGQLSHESSLLFHPVMMDTSLQMLLGALGAPGDGSLYTLMVPTGIERVTINPAFCGPKGAKAAGRTLFADAFITQLDTDGCSGAVEVFTQEGNGMVQMEGVHISPLGPPDRQRQPFSEIAWGPLTPDAGLHSYPYPADLMNHTLLMEQISLINIKQVVDQLTDKDRSGLDWHRSRVVAWMEHVLAMTRTGKHPTCRSEWLDGTQEDIEVLLERLAPSVTGLLAGVVGANMLRFLRGETSMLEEARKDDVLSRFYKEDPESKTMNDRLGDLVGQIAFRYPRMKILEIGAGSGSATKSILERIGSSYHSYTFTDISPGFFEEAKQQFAEHQDHFIYQVLNVEKDPSKQGFEDDSYDLVIAANVLHATKSMKDTMTNVRRLLKPGGYLGLMEVTNTSTIGISFCVGGFEGWWAGEGDGRVWGPMLNASNWENVLQDTGFGGIDTITTLGDARLSAYSVLVSQAVDDRMKVLRQPLSPAHQLKDTAGELVIVGGEKDQTVSLVEEVAHLLEPFFARIVPVQTLELLKGVNISPYATVLSLVDMDGPCFEYLSQSRLQGLQALTVAARKMLWVTTGRECDSPHLGMSKGWLKCLSYEHPEAQYQYLNITDDSTEESTLIAATLMRLVRTDEGNDYSLSSRTSATEPELRFQNGTMSIPRLRASPELNDRYVAGQQLVHKPVNLLESTVRMLPSAKGHYALHLEDKSLVSSHRADIDTELVRIRTRYSTIQAVRVGKDDVFLHLVLGEQEHSHRRLLAYSKDHASIITTPMSWCCDLPDAVRPEFENSFLQATLAAVLARVLVQQATPGSVLWAHEASGVLQQAIRIHAVASGVRPHFTTSSQSLPMEGVSFIHPLVTSRKLVGYLPQDVSVAACFEVEEQGDEGIFSRIKSLLPQCVTVEDTHSLWRTSQQLPEHGNVHHRHLGESLNVASAMAIQFVTSDPTQPVDVKGLSALPPTPRTPKADCIVKWTGSQNEALNVQVKTASQTLTLSSQKTYLLVGMTGDLGRSICHWLITKGARHVVLTSRSPKVDPHWIQEMSKLGANVVPMQLDVSNRESLLHVCDKIQKYHPRIGGVVNGALVLNDCAFDEMPLETMQATFAAKVDGSILLDELFRGDLDFFILMGSLTGIVGNWNQSAYSAATGFQSNLIHQRRARNIVGSIIQPGIITSVGYISRKGSGLAQHVSNTVGSLLLSERDLHEVFAEAILAGHPETSRNPEIVAGMPMANPVTQPDIIWYRNPLCWDFVDYRIQSSSANHAGDGNTCSMKARLESAASMSEAAEIVAAGLADKVRSKFNLASDIALTQDTQLSDLGIDSLVAVDLRSWFVRELSVEIPMLQILSGSSLRALTADSVSKLPPTLLPGILSRDQDFKDVSGLTSPPEVPSDASRSSVSSGMDEIVTPESPSFDQVYRIAGDEMELTKPHQRPIPTPQL
What is the function of this protein?
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of the neurotoxin verrucosidin, a methylated alpha-pyrone polyketide that inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases (PubMed:34093475).  The carbon backbone of verrucosidin is synthesized by the HR-PKS verA, and further modified by the other verrucodidin cluster enzymes (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase verA, HR-PKS verA, Cluster 4 protein A, Verrucosidin biosynthesis cluster protein A.