PharMolix/UniProtQA huggingface dataset:
Protein: CAPP_XANOR
Sequence: MNEYRSSLVFATPDLPLRDDVRRLGALVGDLLAEQVSAEFLDEIERVRTTAISRRESDAPPSTLSEQLTGREPRDAEALVRAFSTYFQVVNIAERVHRIRRRREYQRSGTDTPQPDGLHDALRRLKAQGVTLDELSQWLPRIDVEPVFTAHPTEAVRRALLEKEQLMVASLVDNLDGMRTPNERTSDAARFRMALTASWQTADSSPVRPTVGDEREHVGFYLTQVLYRVIPVMYETLEHAIEETYGSVPALPRLLRFGTWVGGDMDGNPNVDANTIAGTLDAQRRAVLDRYQKELWQLASLLSQSTTLVQVSPELMTQLERYRALLPDAAARSRPRHGDMPYRLLNDLMRARLQATLDDADGAYTAPSELEDDLQLILDSLQANKGLHAGWFAVRRLLWRVRSFGFHLARLDVRQESSVHARAVADALGQTDWDAQDATRRAAVLGPYACGQEALPRVQDEGNARLDAVFAALADARTRHGADALGSYIISMAHNRADVLTVLALARRGGLVDAAGAVPLDIVPLFETVDDLRGGTGTVQDLLADPVYRQHLAARGDTQMVMLGYSDSGKDGGIAASRWGLQRAQVELLEAAADLGVRLTFFHGRGGSIARGGGKTSRALDAAPRGSVDGRLRVTEQGEVIHRKYGIRALALRSLEQMTGAVLLSSLRPRAPEPREARWRPVMDLVAERSTVAYRAFVAAPEFMQYFRLATPIDVIERMTLGSRPSRRLGQDAALSNLRAIPWVFAWSQARAVIPGWYGVGSGLQAAVDAGHEDSLREMAQDWPFFRTFLDDVAMVLSKGDLNIAELFSRLSGDLHTRFFPLIRDELALTKGWVKALLQQQSLLQHDPRLALSIRLRNPYIDPISVLQVDLLQRWRATDGEDEALLRALVACVNGVSQGLQNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: WASP_MOUSE
Sequence: MNSGPGPVGGRPGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATTVVQLYLALPPGAEHWTMEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFADESEAQAFRALVQEKIQKRNQRQSGERRQLPPPPAPINEERRGGLPPVPPHPGGDHGGPSGGPLSLGLVTVDIQNPDITSSRYRGLPAPGPGPTDKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPCRGGGGGGGGGGGGGGGGGGQPLRPPVVGSNKGRSGPLPPVPMGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPPPPPLPGAGGPPAPPPPPPPPPPPPCPGSGPAPPPLPPTPVSGGSPAPGGGRGALLDQIRQGIQLNKTPGALENSVQQPPAQQSEGLVGALMHVMQKRSRVIHSSDEGEDQTGEDEEDDEWDD
What is the function of this protein?
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex.  Important for efficient actin polymerization.  Possible regulator of lymphocyte and platelet function.  Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.  In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
What are the official names of this protein?
Actin nucleation-promoting factor WAS, Wiskott-Aldrich syndrome protein homolog, WASp.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus.
Protein: Y335_CLOPS
Sequence: MRFVIVTGLSGAGKTEATRSLEDLGYFCVDNLPPKLIPKFAEACVQSEGKIDKIALVIDIRGGIFFDDLFESIEYLKANDFNYEILFLEASDEVLVKRFKETRRSHPLSPDGRIITGISEERMRLRELKDRADNIIDTSNYPIRNLREKINLLYGDGKPVEQNLSITVLSFGFKYGIPSDSDLVFDVRFIPNPFYIPELKPFSGEDEPVKNYVLAQEETKGFLSRLSDMAEFLIPNYIKEGKRQLIISIGCTGGRHRSVAIANALYKDLLCKNFHVTLEHRDINEDINRGDRKL
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein CPR_0335.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ANMK_RHOPA
Sequence: MMMTAIGLMSGTSLDGVDVALIKTDGRRVGALGPSGYRPYTETERSLLRQALAEAVQLTARDARPGVLAEAERAVTIAHAEAVAAFVAQNRLSPGSVDIVGFHGQTVLHRPAEKLTVQIGDAKALAKAIRIPVVCDFRAADVAAGGQGAPLVPVYHRALAQSLGRDGPIGVINVGGVSNVTYIDGTDTLIACDTGPGNALLDDFMFRTLGKPFDCEGRLASQGVIDQAWLTEALQHPFFAKPTPKSLDRNDFANLTLRDWSPADGAATLTAFTARAIAAVQPLLPKPPQSWIVTGGGARNLTLMRMLREALAPASVESADALGWSADAMEAQAFGFLATRGLKGLPLSYPATTGVAFPMTGGLLARP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RPOC2_SACHY
Sequence: MAERANLVFHNKEIDGTAIKRLISRLIDHFGMGYTSHILDQIKTLGFHQATTTSISLGIEDLLTIPSKGWLVQDAEQQSFLLEKHYYYGAVHAVEKLRQSVEIWYATSEYLKQEMNSNFRITDPSNPVYLMSFSGARGNASQVHQLVGMRGLMADPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTADAGYLTRRLVEVVQHIIVRRRDCGTIQGISVSPQNGMTEKLFVQTLIGRVLADDIYIGSRCIASRNQDIGIGLVNRFITAFRAQPFRAQPIYIRTPFTCRSTSWICQLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTADLIRSPSNGKIQFNEDLVHPTRTRHGQPAFLCYIDLHVTIQSQDILHSVNIPLKSLILVQNDQYVESEQVIAEIRAGMSTLHFKEKVQKHIYSESDGEMHWSTDVYHAPEYQYGNLRRLPKTSHLWILSVSMCRSSIASFSLHKDQDQMNTYSFSVDGRYIFDFSMANDQVSHRLLDTFGKKDREILDYLTPDRIVSNGHWNCFYPSILQDNSDLLAKKRRNRFVVPLQYHQEQEKERISCLGISMEIPFMGVLRRNTIFAYFDDPRYRKDKRGSGIVKFRYRTLEEEYRTQEEEYRTREEEYRTREEEYRTREEDSEDEYESPENKYRTREGEGEYEILEDEYRTLEDEYETLEDEYGILEDEYRTLEKDSEEEYGSLENKYRTREGEGEYEILEEDSEEEYGSSEDGSEKEYGTLEEDSEEDSEEDSEDEYGSPEENSILKKEGFIEHRGTKEFSLKYQKEVDRFFFILQELHILPRSSSLKVLDNSIIGVDTQLTKNTRSRLGGLVRVKRKKSHTELKIFSGDIHFPEEADKILGGSLIPPEREKKDSKESKKRKNWVYVQRKKILKSKEKYFVLVRPAVAYEMDEGRNLATLFPQDLLQEEDNLQLRLVNFISHENSKLTQRIYHTNSQFVRTCLVVNWEQEEKEGARASLVEVRTNDLIRDFLRIELVKSTISYTRRRYDRTSVGLIPNNRLDRNNTNSFYSKAKIQSLSQHQEVIGTLLNRNKEYPSLMILLASNCSRIGLFKNSKYPNAVKESNPRIPIRDIFGLLGVIVPSISNFSSSYYLLTHNQILLKKYLFLDNLKQTFQVLQGLKYSLIDENKRISNFDSNIMLEPFHLNWHFLHHDSWEETLAIIHLGQFICENLCLFKSHIKKSGQIFIVNMDSFVLRAAKPYLATIGATVHGHYGKILYKGDRLVTFIYEKSRSSDITQGLPKVEQIFEARSIDSLSPNLERRIEDWNERIPRILGVPWGFLIGAELTIAQSRISLVNKIQKVYRSQGVQIHNRHIEIIIRQVTSKVRVSEDGMSNVFLPGELIGLLRAERAGRALDESIYYRAILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGIIPVGTGFQKFVHRSPQDKNLYFEIQKKNLFASEMRDILFLHTELVSSDSDVTNNFYETSETPFTPIYTI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACPS_BRUME
Sequence: MIVGIGSDLIDIRRVEKTLERHGSRFRDRVFTEIEQRKSEGRKQRAASYAKRFAAKEACAKALGTGIAEGVFWRDMGVVNTPSGKPTMHLTGGAAKQLQKLLPAGTNAAIHLTITDDFPLAQAFVIIEALPVLE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_DESA1
Sequence: MSESGGMVKSVHVIPLKRVYFGRRMNRADRAIRLVRKYVARHFKDAEKIILDPELNKYIWSCGREKPPRRVVVEIRFNKNEKEARVFLKRVK
What are the official names of this protein?
50S ribosomal protein L31e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: EFTS_BACCZ
Sequence: MAITAQMVKELREKTGAGMMDCKKALTETNGDMEKAIDFLREKGIAKAAKKADRIAAEGLTFIETNGNDGLILELNSETDFVAKNEGFQTLIKELAAHLLANKPANVEEAMAQTMENGKKVEEHINEAIAKIGEKLTLRRFEIVSKTDADAFGAYLHMGGRIGVLTVLEGSTDEAAAKDVAMHIAAVNPKYIDRDAVTAEEVEHERQVLTQQALNEGKPEKIVAKMVEGRLGKFFEEICLLDQAFVKNPDMKVRQFVESKGGTLKGFVRYAVGEGIEKREDNFAEEVMNQVKGSN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFSA_ECOL5
Sequence: MEFSPPLQRATLIQRYKRFLADVITPDGRELTLHCPNTGAMTGCATPGDTVWYSTSDNTKRKYPHTWELTQSQSGAIICVNTLWANRLTKEAILNESISELAGYSSLKSEVKYGAERSRIDFMLQADSRPDCYIEVKSVTLAENEQGYFPDAVTERGQKHLRELMSVAAEGQRAVIFFAVLHSAITRFSPARHIDEKYAQLLSEAQQRGVEILAYKAELSAEGMALKKSLPVTL
What is the function of this protein?
Binds to DNA non-specifically.  Could be a regulatory factor involved in maltose metabolism.
What are the official names of this protein?
Sugar fermentation stimulation protein A.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: SHLB1_PONAB
Sequence: MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
What is the function of this protein?
May be required for normal outer mitochondrial membrane dynamics.  Required for coatomer-mediated retrograde transport in certain cells.  May recruit other proteins to membranes with high curvature.  May promote membrane fusion.  Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation.  Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy.  Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2).  Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation.  Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
What are the official names of this protein?
Endophilin-B1, SH3 domain-containing GRB2-like protein B1.
What is the protein family that this protein belongs to?
Belongs to the endophilin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody. Note=Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes.
Protein: RL10_METTL
Sequence: MITAESEHKIAPWKIEEVNKLKELLKNGQIVALVDMMEVPARQLQEIRDKIRGTMTLKMSRNTLIERAIKEVAEETGNPEFAKLADYIDKGAAIITTDMNPFKLYKTLEESKSPAPIKGGAVAPCDIEVKAGSTGMPPGPFLGELKSVGIPAAIEKGKIGIKEDKVVAKAGEVVSHKLAVVLSALGIKPVTVGLNLLAAYEDGVIYTPDVLKIDEEEFVQKIQDAYSKAFNLSVNAAIPTAQTIETLLQKAFANARAVSIESAFLTEKTTDDILGKAYSQMLAVAREVGDDALDDELKEKLSTAVVETKAEVEEAKEEEKEEKKEEAAPAAAGLGLLF
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ADEC_DEHMC
Sequence: MQTNLSQLIKVARGETEADLVLLNARVINVFNAEIEQANVAVFDGKIAGVGDYRHGKEVIDLKGAYLLPGLINGHTHVESSMLDIAQYARAVVSHGTLALITDLHEISNVCGKEGIDYVLDASADLPLSIFLQVPSCVPATHLETAGAEINSQDVADLLRLPNVTGLGEMMNFPGVLFGVPSVLDKIIAAAGKVLDGHAPGLSGKDLNAYISAGIHSDHECIHLAEAKEKLARGMYIMIREGSSEKNLAELLPLVTDQTYKRCLFVVDDRSCADLKSDGDIDAVVRKAIRLGLDPVRAIQLASINTAEYFHLQGHGAIAPGYLANMIVCQNLEQLDIDMVFHKGKLVAEKGQALFKPQSRIPKSLLNSIHIRPFDTKDLILKTIQPQIPVIEVIPGQIVTRRLDLKIPAENGVIKANTELDLLKIVVMERHHQSGNMGHGLIRGFGLKKGAIASSVAHDSHNVVAVGTNDADLYTAIKELERINGGIALAVDGQVTASVSLPVAGLLSTKPLEEVVTELEEINNQVAKLGCKLSAPFATLSFMALPVIPELRLTDLGLVDVKTFKLIPQET
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: NIR_ALCFA
Sequence: MAEQMQISRRTILAGAALAGALAPVLATTSAWGQGAVRKATAAEIAALPRQKVELVDPPFVHAHSQVAEGGPKVVEFTMVIEEKKIVIDDAGTEVHAMAFNGTVPGPLMVVHQDDYLELTLINPETNTLMHNIDFHAATGALGGGGLTEINPGEKTILRFKATKPGVFVYHCAPPGMVPWHVVSGMNGAIMVLPREGLHDGKGKALTYDKIYYVGEQDFYVPRDENGKYKKYEAPGDAYEDTVKVMRTLTPTHVVFNGAVGALTGDKAMTAAVGEKVLIVHSQANRDTRPHLIGGHGDYVWATGKFNTPPDVDQETWFIPGGAAGAAFYTFQQPGIYAYVNHNLIEAFELGAAAHFKVTGEWNDDLMTSVLAPSGT
What are the official names of this protein?
Copper-containing nitrite reductase, Cu-NIR.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NANB_ASPNN
Sequence: MRPSTTTLSLLVFLISSILLATTGKNSIIRYTYFPILLIICHLQLTNPPVNTASNIFDGSFEGTTLLNGLQQLNILVLTGVDVNDESGSSVFRRLKSALIYPFNARGVGTKYQIKNLPVLSSFICKEKQGESGLSSFLSSARYRFAIRQLAVSAWQYLLADIGFSLLKNIPTEKRLEYYGPEEEWMPQSLDQLRVRIEATLVFWVTLKAFAEIQSKIATALLTAVGVTSPHDWPPFFGSLREAYTLRGFWGKWWHQQLRWPLTSYSNFITRRVLKLTRSPLERYLNNALVFAQSGIVHVYFNWIKGVQDGDVGCMAFYISFVAGYFLEDHVQGLWRKAFDRTSAQESSLWLLERLVGALWVATFLTIVTPWWVYPFLRLSSSLKMPYSFVDVFGFQGALTVVFMGAAALRIGLNAEP
What is the function of this protein?
Acetyltransferase; part of the gene cluster that mediates the biosynthesis of the benzazepine alkaloid nanangelenin A which contains an unprecedented 3,4-dihydro-1-benzazepine-2,5-dione-N-prenyl-N-acetoxy-anthranilamide scaffold (PubMed:32182055).  The first step of nanangelenin biosynthesis is catalyzed by the indoleamine 2,3-dioxygenase nanC which produces N-formyl-kynurenine through the catabolism of tryptophan (PubMed:32182055).  The two-module NRPS nanA then utilizes anthranilate (Ant) and L-kynurenine (L-Kyn) to assemble the dipeptide product nanangelenin B (PubMed:32182055).  The first adenylation domain of nanA (A1) loads anthranilate onto the T1 domain, while A2 loads kynurenine, generated through spontaneous nonenzymatic deformylation of the nanC-supplied N-formyl-kynurenine (PubMed:32182055).  The peptide bond formation between the tethered amino acids is catalyzed by the first condensation domain (C1) between anthranilate's carbonyl carbon and kynurenine's aliphatic primary amine (PubMed:32182055).  The second C domain (C2) catalyzes the final cyclization event between the aromatic amine of kynurenine and the tethered carbonyl carbon, yielding nanangelenin B (PubMed:32182055).  The terminal T3 domain enhances the catalytic efficiency of C2, suggesting the T2-tethered Ant-L-Kyn is transferred to T3 prior to cyclization by C2 (PubMed:32182055).  Once released from nanA, nanangelenin B is then prenylated by the prenyltransferase nanD to form nanangelenin C (PubMed:32182055).  Nanangelenin C is then N-hydroxylated by the FAD-dependent monooxygenase nanF and further acetylated by the acetyltransferase nanB to yield nanangelenin F (PubMed:32182055).  Finally, the N-methyltransferase nanE methylates the amide nitrogen of 1-benzazepine to convert nanangelenin F into nanangelenin A (PubMed:32182055).  NanE is also able to methylate most of the intermediates of the pathway such as nanangelenin B and nanangelenin C to produce nanangelenin D and nanangelenin E, respectively (PubMed:32182055).
What are the official names of this protein?
Acetyltransferase nanB, Nanangelenin A biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the wax synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YIDD_GLOC7
Sequence: MKIVLIGLIRGYRTFISPLFPPSCRFQPTCSQYGIEAIERFGAIKGAWLTLGRILRCHPFHPGGYDPVPPVKPKK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GRPE_STRMU
Sequence: MSKKDKKEEIKEEVEATEPTTEESVEEVAEETSENKELQEALERAEDFENKYLRAHAEMQNIQRRANEERQSLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMVQESLIQALKEEGVEEVELENFDPNLHMAVQTLDADDDHPADSIAQVLQKGYQLHERLLRPAMVVVYN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y663_PYRAB
Sequence: MVLPLMICYRPIGIIHSPFKEPKDVPIQASAAKDIEGTVEVFPEFSEGLKDIEEFSHIILIYHFHRAKFKGLLVEPYMHEEKHGVFATRAPARPNPIGISVVRLVERKGNILRIRDVDILDGTPLLDIKPYVPEFDVRENVRIGWLEKNVHKLEKARDDGRFFSLNFNYIFPASLLEAPERAKL
What are the official names of this protein?
Probable S-adenosyl-L-methionine-binding protein PYRAB06630.
What is the protein family that this protein belongs to?
Belongs to the tRNA methyltransferase O family.
Protein: RPIA_KLEP7
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGITVFDLNSVDRLGIYVDGADEINGHMQMIKGGGAALTREKIIASVADKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGLEILDAIALENAINGIPGVVTVGLFANRGADVALIGTADGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CSHA_STRPN
Sequence: MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQAQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRSVYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQDIETLILDEADEMLNMGFLEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYYIRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQNKRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADETIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGNGFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNTLSEKQTGFVIRNKGDK
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_CAMHC
Sequence: MEILRTTDELRKFRAAVSQKVGFVPTMGALHAGHISLIKRCKDENEITIVSTFVNPTQFLAGEDLDKYPKNEAADIKICENLEVDAIFIPKADEFYEDDEPKISAPKSLSAILEGATRPGHFDGVLQVLNKLFNLTKPKNVYMGKKDAQQLTIVRNMVQNFFMDINVNACEIVRENDGLALSSRNIYLDEEQKMLALKLSRSLLKAKNLVDASETDINVIKTAMLKILEPLKVDYIAFVDRNFKEISKIEVGNSIILVAAYVDKTRLIDNIWL
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHL1_YARLI
Sequence: MENTKRREFSHPYTPYPIQVDFMEALYDCIESYKVGIFESPTGTGKTLSLICGSMTWLRKNKAQLAVSTASADENEPAWVLEQTIQLAREEFSRNREMLQKRLDKMRRKNMRARISYEQGFKRAKKAPEPVDDSQFLPEDYSEVIKPEVQRLLSALAPPVENDFQEPVKIIFASRTHSQLSQFVGQMQHTTFPPSSDLQDLESTKLISLGSRKQLCINPRVSHMNSVQAMNDACRDLREGKKGGCKYYKNPHDALGKVDINTFRDTTLAEILDIEDLYKLGKHTSTCPYYASRASIPASEVITVPYQILLSRSARKAIDLPVKNSIVIIDEAHNLLDTITSLHTMSITKSQVSSASSGLQKYQHKFQNRLNSGNRVNLGYLVNMLQALEVFFEKAQKFHKKETAPGTPVTTSSLFDGSTADLINVNRLEKYIDESKIVFKIESYLEHVNGETQEKSHSSSLVLSSVMEFLRQVNNPDSEGVLCFDGPTKLKYQLLDPSEPFKDIVENARCVVLAGGTMEPTGDYLEYLLPYLSQDQIKLFSCGHVIPPQNLSVQVIPNGPNYSFNFTFDKRNDEKMILDVAITLLVYSKIIPEGMVVFFPSYKYLEQVVAVWKKAKKDGKNIYEILNDQKRIFVESQHDSVEKTLSEYAEEVPKGAILLSVVGGKMSEGINFSDGLARAVFMIGLPFPNLMSAEIIAKRKYIEQSVSEKMKAKGVSAKEALEASKGAARDFYMNICLRAVNQSVGRAIRHANDYACIFLLDGRFGKPEIQKKLSKWMREGIREGSFKEALGEVQQFFASHEKN
What is the function of this protein?
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity).  May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity).  Has a specific role in chromosome segregation during meiosis II (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase CHL1, Chromosome loss protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRMFO_STRP7
Sequence: MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHKTDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGFSQMVTEKVVNHPLIEVVRDEITELPTDVITVVATGPLTSDALAEKIHALNNGDGFYFYDAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQTYRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEAIFPETTAIGSLAHYITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_BUCCC
Sequence: MKTTLYQKIFDSHLIYEDKNTTPIIYIDLHLIHEVTSPQAFDGLRLKKRLVRNPLKTFATMDHNVSTISRKISDSKKMAKIQMRTLIKNCKDFNIPLYDLKNINQGIVHVIGPEQGMTLPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVFATQTILQNRMKNMRISIYGNIKKNIFSKDIILNIINKIGTSGGTGYVVEFSGSVIKKMSMESRMTICNMAIEMGAKSGIIEPDAITYNYLKNKNFVPKNRSWKEYIRKWNNLKSGPKSFFEQDFSINISHISPQITWGTNPSQVIPINGKIPILKDIQDVNVREDTERSLEYMGLKPGTSLLNIPVDKVFIGSCTNSRIEDLRVVASVVQNKKISDNIEALIVPGSGLVKKQAEKEGLDKIFKNAGFQWRHAGCSMCLGMNEDQLKPYERCASTSNRNFEGRQGPKGRTHLMSPWLAAQTALYGKFVHIA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.