PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_BREBN
Sequence: MIDFVEGTLSYLDSEYIVIETGGIGYRLFCPNPYQFVRYEGNKTKLFTHHHVREDAILLYGFATRDERDLFRKLLDVSGIGPKGGLAILAAATPEQLVMAVQQENVTYLTKFPGIGKKTAQRIILDLKDKLVGYTPSAILTVAAGDLTAGEQAVSALNEALDALTALGYSDGELQKIRNTLSEKSKEGDGVEKLIKQGLALLMRG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PMIP1_CRYNB
Sequence: MLRLPRITRRALSSGALAPHFDRPLPPPPPAPPAPLCALPPLTAPDALAPLTRRTVRHADALVARIAAAPAHPDPAELRRVVKNLDRLSDVLCGVIDMCELVRNVHPDPHWVAAAEKTYETLCSFMNQLNTSTGLYDALVATVSHTFPGNPLSPAELRVAQTFLSDFERSGIQLPPGVRAKFVRHSDNILSLGRTFLSFAAAGPSADTPIEIPEPEVLLAGLSSKFVASLPRKKRKGPALLAPGSWEAQMIGRYADNEEARRLVYIGSMREDKDRVYVLETMLKERAELAHVLGKETWADVALSDKMAKTPQNVLQFLTSLATHHRPSAAADVAALQRLKALSTVSRTSSQLPTVHAWDRDHYAEQYAASLLPNGSLPSITPYFSVGTAMSGLSHMLSRLYGISFKPVSVAHGEVWHPSVRRLDVMDEHGKRIGVIYCDLFSRPGKPSAGAAHYTVRCSRRVDDDPSEGDGLPPGWDQHLGKGMEVQGEALHGKEGKYQLPIVVLTTDFGTVEESGPALLGWNDLETLFHEMGHAIHSMIGQTEFHNVSGTRCATDFVELPSILMEHFISSPAVLSTFATHYTTNEPLPIPLIQAHLQLDQSLKALETHSQILMALLDQKYHSIKHGEQLDSTRVWNELQSQVGVIPPVRGTAWQTQFGHLYGYGATYYSYLFDRAIAGKIWSSLFARGRTGPAAANHDPAAAEDILSREGGEAFKEKVLKWGGGRDPWEMVGDVIGGAEGEQVAKGDEKAMELVGRWMIK
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase 1, MIP 1, Octapeptidyl aminopeptidase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DNAK_BEII9
Sequence: MGKVIGIDLGTTNSCVAVMEGTTPKVIENAEGARTTPSIVAFTDDGERLVGQPAKRQGVTNPERTFFAIKRLIGRTFEDPMTKKDIGLVPYKITKAPNGDAWVEADGKPYSPSQISAFILQKMKETAESYLGQPVSQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKGSGTIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDTRLVEYLADEFKKENGIDLKKDKLALQRLKEAAEKAKIELSSATQTEINLPYITADATGPKHLALKLTRAKFEALVDDLIQKTVEPCRKALKDAGLSAGEVDEVVLVGGMTRMPKVQEIVKQFFGKEPHKGVNPDEVVAIGAAVQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQVFSTAEDNQTAVTIRVFQGEREMAADNKLLGQFDLVGIPGAPRGVPQIEVTFDIDANGIVNVTAKDKATNKEQQIRIQASGGLSEADIDKMVKEAEQHAAEDKVRRELVDAKNHGEAIIHSTEKSLAEFGTKVAESDKSTIDAAIAALKTELAGENLEGIKAKTDALVQASMKLGEAMYKAGAEGGESAEAPKDDVIDADFKEVGPDDHKKSA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: URH1_YEAST
Sequence: MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG
What is the function of this protein?
Also acts on cytidine.
What are the official names of this protein?
Uridine nucleosidase, Uridine ribohydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FLGH_SHEON
Sequence: MARYLLLAAALLLTACSSTPKKPIADDPFYAPVYPEAPPTKIAATGSIYQDSQAASLYSDIRAHKVGDIITIVLKEATQAKKSAGNQIKKGSDMTLDPVYAGGSNLSLGGIPLDLRYKDSMNTKRESDADQSNSLDGSISANIMQVLNNGNLVVRGEKWISINNGDEFIRVTGIVRSQDIKPDNTIDSTRMANARIQYSGTGTFAEAQKVGWLSQFFMSDWWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: SYS_MALP2
Sequence: MINKSIIRNDFKTLETSLKNRNSKLDISSLKDLDKKQSELLLIIESCNKKRNEISKSIGIYIGKKDNKKVDELKKEMESIKNTLETTNEELKTISAKVDDILLSIPNIPDSSVPIGKSEDENVEIKKWGTPTKFDFNHKAHWDLITDLDIGDFERATKVTGSRFFIYKGLGSKLMRALQMLTLDINTSNGYLEMSLPVIVNSASLTSTGQLPKFKEDLFALENSDYYLSPTLEVQLTNYYRNEILEESALPMKFTASSLNFRSEAGSAGKDTRGIIRQHQFYKTELVNLVHPEKSYQALEEMTLNAESILEALELPYRRILLCTGDMGFSSSKTYDIEVWLPSYNSYKEISSCSNCLDFQARRSMIRFKNSKTNKNELVHTLNGSSLALDRLFAAVVENYQNKDGSITIPKALVKYMGIDSIKKTK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C3H10_ORYSJ
Sequence: MAYETSSDHQLAAAAEFLAALQVHLAGAEASSPTWGGRCAYDEDFMMYEFKVRRCPRSRAHEWTSCPYAHPGEAARRRDPSHVTYTGEPCPDFRVAARAACPRGSGCPFAHGTFETWLHPSRYRTRPCRSGMLCARPVCFFAHNDKELRIVGDDAAAATPSPRSPFTTSEDSPPPSPMDMKQIVLAMQQMDARKATRSVAPKTDMLQQELEEDAPELGWVSDLLM
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 10, OsC3H10.
Protein: HEM6_LEGPH
Sequence: MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSP_PLAKH
Sequence: MKNFILLAVSSILLVDLLPTHFEHNVDLSRAINVNGVSFNNVDTSSLGAQQVRQSASRGRGLGEKPKEGADKEKKKEKGKEKEEEPKKPNENKLKQPNEGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANAGQPQAQGDGANVPRQGRNGGGAPAGGNEGNKQAGKGQGQNNQGANAPNEKVVNDYLHKIRSSVTTEWTPCSVTCGNGVRIRRKAHAGNKKAEDLTMDDLEVEACVMDKCAGIFNVVSNSLGLVILLVLALFN
What is the function of this protein?
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
What are the official names of this protein?
Circumsporozoite protein, CS.
What is the protein family that this protein belongs to?
Belongs to the plasmodium circumsporozoite protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Protein: LEU3_CUPPJ
Sequence: MKIAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGHPLPENTLKLAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVAGLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEIRRIAHVAFQAAAKRGKKLCSVDKANVLETFQFWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVIVTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSAAMMLRYSLNKAEQADRIENAVKKVLAQGYRTGDILTPGCKQVGTREMGEAVLAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_BAEIN
Sequence: FGSLLGICLLTQIITGLLLAMHYTADTSLAFTSVAHTCRNVQFGWLIRNLHANGASFFFICIYFHIGRGIYYGSYLNKETWNIGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSTKDILGFALMFILLVSLALFSPNSLGDPENFTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLLPLLHTSKQRSMTFRPLSQILFWALVANLLILTWVGS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YHIT_HELPJ
Sequence: MNVFEKIIQGEIPCSKILENERFLSFYDINPKAKVHALVIPKQSIQDFNGITPELMAQMTSFIFEVVEKLGIKEKGYKLLTNVGKNAGQEVMHLHFHILSGDKH
What are the official names of this protein?
Uncharacterized HIT-like protein jhp_0977.
Protein: FATB2_CUPVI
Sequence: TAASSAFFPVPSADTSSRPGKLGNGPSSFSPLKPKSIPNGGLQVKASASAPPKINGSSVGLKSGGLKTHDDAPSAPPPRTFINQLPDWSMLLAAITTAFLAAEKQWMMLDRKPKRLDMLEDPFGLGRVVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKTAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRREIEPHFVDSAPVIEDDDRKLPKLDEKSADSIRKGLTPRWNDLDVNQHVNNAKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGYGSQFQHLLRLEDGGEIVKGRTEWRPKNAGINGVVPSEESSPGDYS
What is the function of this protein?
Plays an essential role in chain termination during de novo fatty acid synthesis (Probable).  Possesses thioesterase activity for medium chain acyl-ACPs.  Substrate preference is 14:0 > 16:0 > 16:1 (PubMed:21831316, PubMed:29491418, PubMed:30409825).
What are the official names of this protein?
Acyl-[acyl-carrier-protein] hydrolase FATB2, chloroplastic, CvFatB2, Myristoyl-[acyl-carrier-protein] thioesterase, Palmitoyl-[acyl-carrier-protein] thioesterase.
What is the protein family that this protein belongs to?
Belongs to the acyl-ACP thioesterase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IMA6_DANRE
Sequence: MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPPGDESMLECPIQDPDVSSTVPVSGEGVITQDVIQMIFSEDPDQQLIATQKFRKLLSKEPNPPIDEVIGTPGVVNRFVEFLRRSDNCTLQFEAAWALTNIASGTFQHTKVVIETGAVPIFIELLNSEYEDVQEQAVWALGNIAGDNAECRDYVLNCGILPSLQQLLAKSNRLTTTRNAVWALSNLCRGKNPPPDFAKVSPCLSVLSRLLFSSDPDVLADACWALSYLSDGPNDKIQTVIDSGVCRRLVELLMHSDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIKKEACWTVSNITAGNRAQIQAVIDSNVFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLNTIKPMCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEEDASIVPQVDQNQGQYIFQQSEGPMEGFQL
What is the function of this protein?
Functions in nuclear protein import.
What are the official names of this protein?
Importin subunit alpha-6, Karyopherin subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPC_AERHH
Sequence: MCIQPNDNWQWHYDAHDDRLMLDLSDRMIFATEYKGRQLVPSSFTTQPFCVDDAALYYQLMDRVAELEWSVPHQVQLVLNAIAVSRFYKPLMPQSWFFGETHPAIIPETGALVCMGTPHGKGEFLVIEAGEQASVCLNLTDDLILTTSKTLPRFGVIKVMNNRMSPRPVAQAQYRQVS
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_SHIF8
Sequence: MNTLPEQYANTALSTLPGQPQNPCAWPRDELTVCGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPFDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPQARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: Y2368_YERPN
Sequence: MSVTDLVLVVFIALLLIYAIYDEFIMNMMKGKTRLQVHLKRKNKLDCMIFVGLIGILIYNNVMAHGAPLTTYLLVGLALVAVYISYIRWPKLLFKNTGFFYANTFIEYSRIKSMNLSEDGILVIDLEQRRLLIQVKKLDDLEKIYNFFIENQS
What are the official names of this protein?
UPF0266 membrane protein YPN_2368.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS2_CHESB
Sequence: MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKALIAESADLVYHWLVVLKIAGVRLDEVMLELESRTGRSGIAEKESRGKPPESAA
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMIP_MOUSE
Sequence: MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRRLVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLAAVLTPEERATRAGLGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDSNLRSQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGRDLEVQEDLLTIINLTHHFSVGALMSAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQPLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYLREISEELQISKVFAAAAFERICTFEGKLSSLQRHMEEVNLTDFPAFSIIVDELKQQFKEDQKIFDPDRYQMVISRLQKDFERHFKDLRFIKKDLELFSNPFSFKPEYAPISVRVELTKLQANTDLWNEYRVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFAYLTRNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS
What are the official names of this protein?
EPM2A-interacting protein 1, Laforin-interacting protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: MPPO_STRHY
Sequence: MLTLHLQDDDVAAIDAVADELSRRYDSVESTEFQAESRLYADELPRRVRRALHEYRSTEKSGILVVTGLPVDDSALGATPADRRHKPVPSTSLRQDIAFYLIANLLGDPIGWATQQDGFIMHDVYPVQGFEHEQIGWGSEETLTWHTEDAFHPLRTDYLGLMCLRNPDGVETTACDIADVEIDDETRETLSQERFRILPDDAHRIHGKAPGDESARESALRERSRQRVASALESPDPVAVLFGDRDDPYLRIDPHYMQGVQGETEQRALETIGAAIDDAMSGVVLSPGDIVFIDNYRVVHGRKPFRARFDGTDRWLRRLNIARDLRKSREARLAATTRVIY
What is the function of this protein?
Hydroxylates the beta carbon of free L-enduracididine to produce (3S)-3-hydroxy-L-enduracididine in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of antibiotic mannopeptimycin.
What are the official names of this protein?
Enduracididine beta-hydroxylase, Mannopeptimycin biosynthesis protein O.
What is the protein family that this protein belongs to?
Belongs to the clavaminate synthase family.
Protein: OLA1_RAT
Sequence: MPPKKGGDGLKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQCHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLLLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKSDPGALVIPFSGALELKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYDDFKDEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQSKKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP.
What are the official names of this protein?
Obg-like ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.
Protein: FOLD_PROA2
Sequence: MMLIDGKKVSTDLKNELKTRVEELKAKAGCVPGLTVIIVGEDPASQVYVRNKAKSCKETGMNSTVIELPAETTQEELLGKIEALNQDPDVHGILVQQPLPSHIEEYAVTMAIDPAKDVDGFHPENVGQMVLGNLDKCFISCTPFGILELLRRYDIETRGKHCVVVGRSNIVGKPMANLMLQKLRETNCTVTVCHSATQNMPELTRQADILIAAIGRANFITREMVKPGAVVIDVGINRIEDPSRKSGFRLAGDVDFDNVAEMASAITPVPGGVGPMTIAMLLKNTLQSFARSHNL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CSN6_MOUSE
Sequence: MAAAAAAGANGSGGSSGMEVDAAVPSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).  Has some glucocorticoid receptor-responsive activity (By similarity).  Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 6, SGN6, Signalosome subunit 6, JAB1-containing signalosome subunit 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GALM_HUMAN
Sequence: MASVTRAVFGELPSGGGTVEKFQLQSDLLRVDIISWGCTITALEVKDRQGRASDVVLGFAELEGYLQKQPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEPNSLHGGVRGFDKVLWTPRVLSNGVQFSRISPDGEEGYPGELKVWVTYTLDGGELIVNYRAQASQATPVNLTNHSYFNLAGQASPNINDHEVTIEADTYLPVDETLIPTGEVAPVQGTAFDLRKPVELGKHLQDFHLNGFDHNFCLKGSKEKHFCARVHHAASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQPRFPPVLLRPGEEYDHTTWFKFSVA
What is the function of this protein?
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898).  Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973).  Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898).  Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898).
What are the official names of this protein?
Galactose mutarotase, Aldose 1-epimerase.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCT2B_MOUSE
Sequence: MAHQNQHQDTIDSTEVEVWDSRTAQEVNKSLYPPAVDSPFTLNTHLSAWRWACTIILGTVLVPVRVSCIVFLLILLWPVAVLSAINLPTQPTKPIRRWRKHLIKSALVFLFRLGFFFAGFLVKVKGKKATREEAPIFVSAPHSTFFDAIAVVVAGLPSVVSDSQLARVPLAGKCILVTQPVLVKREDPNSRKTTRNEILRRVKSKMKWPQILIFPEGLCTNRSCLVTFKLGAFSPGVPVQPVLLRYPNSLDTVTWTWNGFSGFQVCMLTLSQLFTRVEVEFMPVYIPSEEEKKDPILFANTVRIKMANALKLPVTDHSLEDCKLMISAGALQLPMEAGLVEFTKISQKLKLDWDNIHKHLDQYASFAVSSKGGKIGIEAFSRYLKLPISEPLRQLFSLFDRNQDGTIDFREYVIGLTVLCNPSNTEKILQMSFKLFDLDEDGYVTERELTTMLQAAFGVPDLDVSTLFQQMAGKDSDQVSYRTFRRFALKHPAYAKLFHSYIDLQAAYIYSLPREV
What is the function of this protein?
Probable acetyltransferase.
What are the official names of this protein?
Lysophosphatidylcholine acyltransferase 2B, Acyltransferase-like 1-B.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.