PharMolix/UniProtQA huggingface dataset:
Protein: BESA_BACSU
Sequence: MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPSTPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSARHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIFGHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINILLAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALRFALHPDGPHLSMG
What is the function of this protein?
Catalyzes the hydrolysis of the trilactone cycle of ferri-bacillibactin (ferri-BB) complex, leading to the formation of bacillibactin monomers and to cytosolic iron release, thus making iron available for metabolic use.  Can also hydrolyze bacillibactin (BB), however the catalytic efficiency for ferri-BB hydrolysis is much higher than for BB.
What are the official names of this protein?
Ferri-bacillibactin esterase BesA, Bacillibactin trilactone hydrolase.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHPB_HALH5
Sequence: MTKRRVSGKTVEEAVEQAIIELGTTRERITYTVVEEPKSGLFGILGSKPAVIEVVVKPDPVDRAKAFLEELLQEMDMEVEVTIEKDPATVLFNISGEQDLGTLIGKRGQTLDSLQYLVNLVANKEEGEFIRIKLDAENYRARRKEALVQLAERLASKALRTKRPVSLEPMSAHERKIIHTALQELGDVETYSEGQGIGRHVVIAPKR
What is the function of this protein?
A probable RNA chaperone.  Forms a complex with KhpA which binds to cellular RNA and controls its expression.  Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
What are the official names of this protein?
RNA-binding protein KhpB, RNA-binding protein EloR.
What is the protein family that this protein belongs to?
Belongs to the KhpB RNA-binding protein family.
Protein: MSCL_SALTY
Sequence: MSFIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAFTLREAQGDIPAVVMHYGVFIQNVFDFVIVAFAIFVAIKLINRLNRKKAEEPAAPPAPSKEEVLLGEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CPSF6_MOUSE
Sequence: MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQSPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGGSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery.  Plays a role in mRNA export.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 6.
What is the protein family that this protein belongs to?
Belongs to the RRM CPSF6/7 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs). Distribution in speckles and paraspeckles varies during the cell cycle. Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules. Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status.
Protein: ATPF_PEA
Sequence: MQNITDGSFGFDTDILATNLINLSAVLGVLIFFGKGVLSDLLDNRKQRILRTIRNSEELRETAIEQLEKARARLRKVEMEADRFRVNGYAEIEREKLNLINSIYTSLEQFENDKNKTIHFEQQRAINQVQQSVLQQALQGALGTLNSCLNNELHLRTIGATIGMFGSMKAKK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS4_SULIM
Sequence: MGDPKKSRKKWESPGHPWIKERIGYEQELLGKYGLRNKREIWIAQSIIRKFRHQARSLLALPPAERAVREKQLVGKLLKMGLLKRETATVDDILSLTEQDLLERRLQTIVYKKGLANTTYQARQLIIHGHIAVNGKRVTSPGYIVNVDEENLIDYYVTSSFKSRPPVMAQQEGGEAGVKQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: 463L_IIV6
Sequence: MNHFVYLMDKYGNPYSFSLKPKYYKTLVLSGGAMRGVYLLGALNGLKIKINKISTFIGISSGSIICFLLSIGYTPYEIFISLLKYDNLLTINLDKLYSGDTRNEGGLFSSENIFKHLETQMRLKEISRSITFKEHFEKTGKILIVMAFNITKCKEDIFTYETTPDMEILNSLKLSARIPIIFGPIKYNNNFYIDGGVWNNFPIDIAIKYHNKKNKKKSDWIIAVTTLFSTYKQNIHQWYKFSNINIVMVNDTPDLNPSLVSSDLEKLTMFNKGEEKASLIKKQNIRRNSI
What is the function of this protein?
Probable lipid hydrolase.
What are the official names of this protein?
Probable lipid hydrolase 463L.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: QUEF_MACCJ
Sequence: MSGRQKEELQDITLLGNQNNKYLYEYDKTILESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFAAIYISYIPNIKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPGTKYEEMASYRLMNHDLYPETITNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_LARHH
Sequence: MNDNKAWSGRFAEPVAELVKTYTASVDFDRRMAEFDIQGSLAHAQMLTRAGVLSETDLDAIRSGMHTILEDIRAGRFEWSVDLEDVHMNVEKRLTDRIGDAGKRLHTGRSRNDQVATGIRLYLRDAIDRIVGFVRGLQAALLDLAEPNAATVMPGFTHLQVAQPVTFGHHLLAYVEMLGRDAERMQDCRKRVNRLPLGAAALAGTTYPIDRHYTAELLGFDDVCHNSLDAVSDRDFAIEFTAAASLVMTHLSRLSEELILWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELVRGKAGRVTGHLMALLMLMKAQPLAYNKDNQEDKEPLFDTVDTLIDTLRIYADMMRGITVRPEAMRAAVLQGFATATDLADYLVKKGVPFRDSHEIVARTVKLAEVQGCDIADLPLDELREFSELIEADVYDVLTPEGSLAQRNHVGGTAPEQVREQIARWRQRLAHA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTT1_DROER
Sequence: MADFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGDQLKPEFVKINPQHTVPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQEYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNRWYENAKKVTPGWEENWAGCLEFKKYFE
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Has DDT dehydrochlorinase activity (By similarity).
What are the official names of this protein?
Glutathione S-transferase 1-1, DDT-dehydrochlorinase, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: RS7_TREPR
Sequence: MARKCGAVKLRSCCDPLFEAPEVGRLVNLVMVSGKKTVAARIVYTALAMLSPDRRRSYELLMQALHNIKPSAEIRTRRMGGASYRVPAEICSKRRMSLALRWLKSAAMRRRERYAHVRLYNEILDALSRRGGAVRQRDEVHRLAHANRAFSHSRRG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS20_CLOBB
Sequence: MANIKSAKKRIKVTETKTLNNRMIKSALKTVIKKFEAAVAGNNVEEAKTVFVAVTKSLDVAASKGVVHKNMAARKKSRLAAKLNAMA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RNH_NITOC
Sequence: MTEIVEIFTDGACRGNPGPGGWGALLCYQGREKTLSGAESKTTNNRMELMAAIRALETLKRPCRVHLTTDSQYLRQGITCWLSNWKRRGWKTANRQPVKNIDLWQRLDQVAAQHRIEWFWVRGHEGHPGNERADALARSAITNGEEK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAE_SALA4
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETSVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: HS3SA_MOUSE
Sequence: MAPSGPTGAQPSPAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCPPGSGPVAGVPGRGVPAGPRELAMWPAGAPRKRLLQLRQRRRRGRSGPGDSSDQEEQSPGLAAAPGGSGAGSSVAEAQPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLEGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIGLYAKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLKRIITDKHFYFNQTKGFPCLKKAEGSGKPHCLGKTKGRAHPTIAREVLRQLRDFYRPFNRKFYQMTGRDFGWDG
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate.  Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2.  Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).
What are the official names of this protein?
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, Heparan sulfate 3-O-sulfotransferase 3A1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: ISPD_BURMA
Sequence: MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAIRRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: SYT_AERHH
Sequence: MPIITLPDGSQRQFAHAVSVMDVAADIGPGLAKACIAGRVNGELVDACELIEADASLAIITAKDEEGLDILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDIDLDRTLTDEDLAALEERMLALAAKDYDVIKKKVSWQEARDVFEARGETYKVEILDQNIARDDQPGLYHHEEYIDMCRGPHVPNMRHCHHFKLQKMSGAYWRGDSNNKMLQRIYGTAWADKKQLKSYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFIRGKLKEYDYQEVKGPFMMDRVLWERSGHWEKYAQAMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIMEEVSACIRMVYDVYGTFGFENIVVKLSTRPEQRIGSDEAWDRAEAALAEALVLNGLKYDLQPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDFALPGRLGATYVGEDNERHVPVMIHRAILGSLERFIGILTEEYAGLFPTWLAPTQAVVMNITDNQADYAVKVAKALNDAGLRAKADLRNEKIGFKIREHTLKRVPFMLVCGDKEVEAGKIAVRTRKGADLGTYPVEELIALLTQEVQTRGQKKVEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_ERWT9
Sequence: MHDTFKHTTVLLDEAVNGLNIKSDGIYIDGTFGRGGHSRLILSQLGEHGRLYAIDRDPQAIAAAAEITDPRFTIIHGPFSALAEYAEERGLKGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLLKAEESDIAFVLKTFGEERFAKRIARAIVERNREQPMTRTKELADVIYAATPVKDKFKHPATRSFQAIRIWVNSELEEIEQALKGALSALTAGGRLSIISFHSLEDRIVKRFMREQSRGPQIPHGLPMTEAQLSSLGGRQLKALGKMMPGESEVADNPRARSSVLRIAERTAS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED21_ASHGO
Sequence: MTDRLTQLQQCLDQIVEQFGSAITYVDRNHDFEPHNELEDKLSDPQATIAAAEDFDRNIDELTTDMILKTRQIIKLIDSLPGVDVSAEEQLSRIDSLQKKLIQVEGEKIEAIKRKESLTKDIEELINEFTEGIANSRRLNKA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KPRS_VIBPA
Sequence: MPDMKLFAGNATPELAQRIADRLYISLGDASVSRFSDGEVAVQINENVRGSDVFIIQSTCAPTNDNLMELVVMIDAMRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMQSRGLDNPVVVSPDLGGVVRARATAKALGDIDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERGAKRVFAYATHAVFSGNAADNIKNSVLDQVIVTDSISLSKEMAATGKVTTLSLSRMLAEAIRRISNEESISAMFN
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNJ5_BOVIN
Sequence: MAGDSRNAMNQDMEIGVTPRDPKKIPKQARDYIPIATDRTRLLSEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYIRGDLDHVGDREWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIVLLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISLRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIICHEINEKSPFWEMSRAQLTQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYHPSPPLPGGCVGAELGAEAEQEGEEEPEGLSGSQETKDSA
What is the function of this protein?
This potassium channel is controlled by G proteins.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  This receptor plays a crucial role in regulating the heartbeat. Can be blocked by external barium.
What are the official names of this protein?
G protein-activated inward rectifier potassium channel 4, GIRK-4, Cardiac inward rectifier, Heart KATP channel, Inward rectifier K(+) channel Kir3.4, KATP-1, Potassium channel, inwardly rectifying subfamily J member 5.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: FOLD_PSELT
Sequence: MIIDCRSISKEIDEETLKLLTICKTKPKLVSFTINPDSGTISYLKSQQKKARSLGIEYETRVLDSVDDLKSDILNASKDSSVHGIFVSHPLPAGINEMEIAKLVDPEKDIEGRNPLNMGYLIYGKEDFAPCTATAVVRILTSVTSVTGKQVVIIGRSTTVGQPAAIMLLRRDRSATVTVCHSKTRDIPSITKKADIIIVAVGKAGFLKKDMVKEEAVVIDVGINILDGKIAGDVEQSVQEIAYLTPVPGGVGLVTTSVLMNRVAKNASRGDSN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PFL_STRMU
Sequence: MATVKTNTDVFEKAWEGFKGTDWKDRASISRFVQDNYTPYDGDESFLAGPTERSLHIKKVVEETKAHYEETRFPMDTRITSIADIPAGYIDKENELIFGIQNDELFKLNFMPKGGIRMAETALKEHGYEPDPAVHEIFTKYATTVNDGIFRAYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNSIAEIDEESIRLREEINLQYQALGEVVRLGDLYGLDVRKPAMNVKEAIQWINIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDELYSGDPTFITTSMAGMGADGRHRVTKMDYRFLNTLDNIGNAPEPNLTVLWSSKLPYPFRHYCMSMSHKHSSIQYEGVTTMAKEGYGEMSCISCCVSPLDPENEDRRHNLQYFGARVNVLKALLTGLNGGYDDVHKDYKVFDVEPIRDEVLDFETVKANFEKALDWLTDTYVDAMNIIHYMTDKYNYEAVQMAFLPTRVKANMGFGICGFSNTVDSLSAIKYATVKPIRDEDGYIYDYETVGNFPRYGEDDDRVDSIAEWLLEAFHTRLARHKLYKDSEATVSLLTITSNVAYSKQTGNSPVHKGVYLNEDGSVNLSKVEFFSPGANPSNKASGGWLQNLNSLKKLDFAHANDGISLTTQVSPKALGKTFDEQVANLVTILDGYFEGGGQHVNLNVMDLKDVYDKIMNGEDVIVRISGYCVNTKYLTKEQKTELTQRVFHEVLSMDDAATDLVNNK
What are the official names of this protein?
Formate acetyltransferase, Pyruvate formate-lyase.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3252_HALH5
Sequence: MEVREIRKQLEEKLNRPEWTLSYDHKEAKLRIEDKELKKGMTIALKPLLAKVERLGDRAISEMVHYVQTGMAAFKKQTTIKGNEKRIFPVIRATSFPEENRDGHRLLFDEHTAETRVYYSLDLGDSYTLLHEQQLSREEMSAKEIREMALFNLRSLSEPLKADKVAGNTFYFLNSNDGYDASRILNESLLEKMSQKVEGQLAVAAPHQDVLIFADIVNERGYDVLAQVTMQFYAQGRIPITALPFLYENGELEPTFILAQRKPKE
What are the official names of this protein?
UPF0354 protein BH3252.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: POTA_PASMU
Sequence: MESSVQNKPIIELRSITKSYGDKTIIENFNLTINNGEFLTILGPSGCGKTTVLRLLAGLEELDSGNIILDGEDITHVPAEQRHVNTVFQSYALFPHMTIFENVAFGLRMQKVPNEEIKPRVLEALRMVQLEEYAYSKPAQLSGGQQQRIAIARAVVNKPKVLLLDESLSALDYKLRKQMQNELKALQRKLGITFIFVTHDQEEALTMSDRIIVLRKGHIQQDGSPREIYEEPKNLFVAKFIGEINIFNATVLTRVDEKRVRANVEGRVCDIYTNLDVVAEQKLKVLLRPEDILIEELDENQSSKAIIGHVADRNYKGMTLESNITLDHNGMTVLVSEFFNEDDPNIDHSLGQKVALTWHEGWEVVLSDEE
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LANA_BLAHA
Sequence: MRNDVLTLTNPMEENELEQILGGGNGVLKTISHECNMNTWQFLFTCC
What is the function of this protein?
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria.  The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.  Ruminococcin A is a broad spectrum bacteriocin exhibiting activity against a wide range of pathogenic clostridia and B. longum (By similarity).
What are the official names of this protein?
Ruminococcin-A.
What is the protein family that this protein belongs to?
Belongs to the type A lantibiotic family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNY_MYCGA
Sequence: MITISILLMYLIVGLLTALTVLIFVFILLKFYEFRFFKQTETYQRELEQEILKINNQEELEEKLKEHYLFQSNHKVFTKRDLREIRNFFIAVLSDKILLENKNKLLSNEIIEKKKENEELKTKLDAKKVEEKITLLKEMNLTHEEAKKRLLEEYRGYVRNDLDKMVKEEEKAANDKKNAITNELNKLLINAMGNVSLLTETVRMNTVKTIKYEYVDVDPIKVKKVTDDFFGKIIGKEARNKKYIERLFNVEIIIKPESSRISISSFNTIKLEVAYNALNKIIEAVNDQGTHVLDESLIRKSWYGALNEFSAEAKRIGEETLKELGLYESAFIPTKEISEFIGRLKFRGSNTQNVLTHSIEAAQIAESIADQLNLNKEKAKVCALLHDIGKAIDKESVSSEGKWKNLKYAANDHVSAGVEIAQYYKFDIDIIDAINCHHGRKKIYEKSKNFYAKITKIADFLSAARPGVRFVKDNDIERRFDTISNILTKYVDEKIISTYKILKNGYNINLMINPDITESEYSQLTLDLKKDIESDKELSKYPITITYVQNITRSETTNAIAHAKKTVEIYSEDKAELVNDEELSTVEFLDEDI
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.