PharMolix/UniProtQA huggingface dataset:
Protein: MRAZ_BURMA
Sequence: MFQGASALTLDAKGRMSVPSRYREALQGQAEGRVTVTKHPDGCLLLFPRPEWEVFRAKIAALPMDAHWWRRIFLGNAMDVDLDSAGRILVSPELRMAAGLEKEVMLLGMGSHFELWDAQTYTAKEQAAMAQGMPEALKNFTF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PPK1_BURA4
Sequence: MSVRYPLLNRELGILGFNERVLAQAADPQVPLLERLRFICITSSNLDEFFEVRMAGLQEQIRDNPGALTPDGMSLQHAYDLVVERAQRLVHRQYTMLHETVLPALEQEGIYFHAADTWNDEQLEWARRYFLDELLPVLTPIGLDPAHPFPRVLNKSLNFVVELEGRDAFGRQAVMGIVQAPRALPRVVRMPQALSGFEHGFVLLSTFMQRFVGELFPQLVVKSCNQFRITRNSELFVDEDEITNLRVALQGELPARHLGNAVRLEVSADTPAHIVRRLLEESLLDEKDCYRVAGSVNLVRLMQIPDLVDRPDLKFAPFTASIPPVIANAPAMFDAIDDGDILLHHPYESFQPVLELLQQAAKDPSVVAIKQTIYRTGTDSPLMDALMAAARNGKEVTVVVELLARFDEETNINWASQLEAVGAHVVYGVVGHKCHAKMMLIVRRVVESGKATLRRYVHLGTGNYHPRTARLYTDFGLMTADQKICEDVHHVFQQLTGIGGELTLHELWQSPFTLHPRIIESIRAEIDNARAGKRARVVAKMNALLEPTVIAALYEASQAGVKVDLIVRGVCALKPGVPGLSENITVRSIVGRFLEHHRIYYFHADGAEEVYLSSADWMDRNLFRRVEVAFPIRERKLKRRVIAEGLSVCLGDNQSAWLMQSDGHYRRRRAGKTLRNAQLGLLAKFCS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: METK_GLOC7
Sequence: MTRRYLFTSESVTEGHPDKICDQISDTILDALLSQDPYSRVAAEVVVNTGLVLITGEITSKAQVNYVDLARQKIAEIGYTDSNNGFSANSCAVLVALDEQSPDISQGVTKAQERREQLSDDELDHIGAGDQGLMFGFACNETPELMPMPISLAHRIARRLAAVRKTGELPYLRPDGKTQVSVIYEDGKPVGIDTILISTQHTETLGQITDNAAIQKTIKDALWQAVVTPSFGDIEIKPDNNTKFLVNPTGKFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRHVAKNIVAAGLADKCEVQVSYAIGVARPVSIMIETFGTGKVSEEKLLEFVKEHFELRPAGIIQAYNLRHIPQERGRFYQDVAAYGHFGRTDLDLPWEKTDKVALLKDAFSQPAIVAG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIR4_SALTY
Sequence: MKLSRISAINWNKIQDDKDLEVWNRLTSNFWLPEKVPLSNDIPAWQTLSAAEQQLTIRVFTGLTLLDTIQNIAGAPSLMADAITPHEEAVLSNISFMEAVHARSYSSIFSTLCQTKEVDAAYAWSEENPPLQRKAQIILAHYVSDEPLKKKIASVFLESFLFYSGFWLPMYFSSRGKLTNTADLIRLIIRDEAVHGYYIGYKYQIALQKLSAIEREELKLFALDLLMELYDNEIRYTEALYAETGWVNDVKAFLCYNANKALMNLGYEALFPPEMADVNPAILAALSPNADENHDFFSGSGSSYVMGKTVETEDEDWNF
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.  R2F contains the tyrosyl radical required for catalysis.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase 2 subunit beta, R2F protein, Ribonucleotide reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: UP23_PSEMZ
Sequence: MQVNLRCSE
What are the official names of this protein?
Unknown protein 23.
Protein: LEPA_BORGP
Sequence: MSISIRKKNFCIIAHIDHGKSTLADRFIQKAKIISDRDFKSQMLDSMEIERERGITIKSQVVTITYKSNDGDCYELNFVDTPGHVDFSYEVSRAISSCEGALLLIDASQGIQAQTVSNFYMAFEHDLEIIPVINKIDLPNANIDFVKKQIKNDLGLNEEIAISISAKNGIGIDDLLEAICKHVPSPRGSIKDPLRALIFDSHYDSYRGVVVHFRIFEGQIKTGDKIRLMHTNSEHLIEEIGVFKISLERKDRLEAGDVGYFIAGIKNISDVKIGDTVTLCDCPALSPLEGFKEVKPVVFSSVYPVDANQYDDLLKAMDRLKLNDASLTFEKDSSSALGHGFKCGFLGLLHLEVIQERIEREFDLNVILTSPSVRYKIIPKKGESYFIESPEQFHGNEAIEGVLEPYIRANIIVPTEFLGNIMSVCLLKRGVQTSLIYLDTKRVELIYKMPLSEILFDFYDKIKSVSRGYASFDYELLDYEYTDLVRLDILVNGDRVDALSQLVFKDSAKTKAIGICKKLKDEIARQQFKIAIQGAIGSNVIARETISPVRKDVTAKCYGGDITRKRKLLEKQKEGKKRMKMVGNVEIPQRAFLAVLKSNDN
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LOL1_ARATH
Sequence: MPVPLAPYPTPPAPALAPSYNTPPANGSTSGQSQLVCSGCRNLLMYPVGATSVCCAVCNAVTAVPPPGTEMAQLVCGGCHTLLMYIRGATSVQCSCCHTVNLALEANQVAHVNCGNCMMLLMYQYGARSVKCAVCNFVTSVGGSTSTTDSKFNN
What is the function of this protein?
Positive regulator of reactive oxygen-induced cell death.  May be involved in the repression of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade.  LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death.
What are the official names of this protein?
Protein LOL1, Protein LSD ONE LIKE 1, AtLOL1, Putative zinc finger LOL1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MBF1_ASHGO
Sequence: MSSDWDTNTVIGQRVRTGGSGPRQQVARTQGQINAARRAGLVLSVDKKYASSNTKANNEGQRLTMVDRETDIVKPKKLDPSVGRAIAKGRGDKGMTQKDLATRINEKPTVINDYEAGRAIPNQQILAKMERALGVKLRGKGIGEPLGGPKKK
What is the function of this protein?
Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.
What are the official names of this protein?
Multiprotein-bridging factor 1.
What is the protein family that this protein belongs to?
Belongs to the MBF1 family.
Protein: MDTI_ENT38
Sequence: MQQFEWIHAAWLAFAIVLEIIANVFLKFSDGFRRKWFGLLSIAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWVLFGQRLNRKGWIGLVLLLAGMVMIKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MLTC_MANSM
Sequence: MKLKKFLVLLLIPFLYACSSDRSGNYDDAFAKDTNGLDLLTGQFSQNIDQIWGVNELLVASRKDYVKYTDSYYTRSHISFEEGQITIETLADANRLHSAIVHTLLMGSDAKGIDLFASGDVPISSRPFLVGQVVDNFGRQINNIDVANSFASYLLQNRLQSRRLSNGRTVQFVSIQMIANHVNVRARKYLSLVRQASRRYGIDESLILGIMQTESSFNPYAISYANAMGLMQVVPHTAGRDIFKLKGRSGQPSKSYLFDPANNIDAGVSYLWILKNEYLAGITNPTSMRYAMISAYNSGAGAVLRVFDSDQEYAINIINRMQPEQVYRILTTVHPSSQARNYLLKVDKAQRSYRRAR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: HEM1_GEOMG
Sequence: MNIVVVGLSHKTASVDIREKVAFAPTQMEKPLRALLAIEDIAEAVIVSTCNRVEVYISTRDIAGGMARIKRFLADYHGISPEILEPHLYAHHGEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEFKTSGIILNRFLHKAFSVAKRVRTETKIASSAVSVSFAAVELARKIFGNLSDKTVMLIGAGEMCELAAKHFINNGVRGVMVTNRTYERAVKLAEEFEGKPVSFDDLFDQLHKADIVLSSTGATQFIIKPKDVEEVIRRRKLKPMFFIDIAVPRDIDPKVNDVENVYLYDMDDLQGVVASNLQQRAEEAKKAEAIIDEEIGQFHKWLSNLEVTPTIVALRSKFEETRKAELEKTLASWKDLPPDGAKRLEALTTAIVNKLLHPPTATLKRVGQGGRTDLYVDALRTLFELQTGESEAEELGELEE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: SECG_STAAM
Sequence: MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
What is the function of this protein?
Involved in protein export.  Participates in an early event of protein translocation (By similarity).
What are the official names of this protein?
Probable protein-export membrane protein SecG.
What is the protein family that this protein belongs to?
Belongs to the SecG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CP2L1_PANAR
Sequence: MLTGALLLLLLVVIVYLLDKKPSGLPPGIWGWPLVGRMPSRSKHLADQVKQLRKKYGDIITWRIGTRVNVFLCNFKLVKTALSKFECSDRPDFYTFKLFGEGNDVGVVFSNGVMWQTHRRFILRQLRDLGMGKSRLEAAIQHEAACLVQELKKHTDQPMPLPKSINLAVLNVIWKLVADHRYSLQDQEGQYFTQLLTTTTDNMQGFALNLFNYLPWLLMITPDFVKNWMGVRVLRDGVCELKDYMKTFIKEHQATLDPSNPKDLLDAYLIDLQERKEDPLSTMNIETVRAVIMDLFGAGTETTSTMIRWTILYLMKYPEVQAKIQREIDAAVPRGTLPSLEHKDKLAYFEATIHEVHRIVSLVPLGVSHYTNQDTELAGYRLPKGTVVMSHLECCHRDPSYWEKPNEFYPEHFLDDQGKFVKREHLVNFSVGRRVCVGESLARMELFVFLSAILQNFTFSAPKGEVLHTEKDPQQMLFSFPKPYQVIIRERE
What is the function of this protein?
Efficient in catalyzing the monooxygenation of benzphetamine, aminopyrine, benzo(a)pyrene, progesterone, and testosterone.
What are the official names of this protein?
Cytochrome P450 2L1, CYPIIL1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: ZN830_XENTR
Sequence: MADAGKKKLVQQEELRRLMKAKQRRSCSKKRIESPLAKYNSLGHLLCVVCNIQIKSELLWPAHILGKQHKEKVAELKGSKANISSPSNKVQLHHIMKRKGSEPENQESKRIKGTEDQPTALKTKLPEGFFETEETSSAKHAAEKAPSLKLLAGDYEDDDEVEGEEYENVNEASTSLQKPAEIPLPPPTSSADRLPADFFESKMPLVSHSGSVLKADIQEKIVERKDNTAEALPEGFFDDPEADAKVRKVDAPKDQMDKEWEEFQKEIRQVNSVSDAIVAEEDEEGRLDRQIDEIDEQIECYRRVEHLRDLKDTLQDAKMEVLKSKSSKKWQEEIGSDDEETLPSLLYKNWRDKGAFL
What is the function of this protein?
May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity.
What are the official names of this protein?
Zinc finger protein 830, Coiled-coil domain-containing protein 16.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Nucleus speckle. Note=Excluded from nucleolus.
Protein: RK33_PHYPA
Sequence: MAKNKDVRVTITLECTNNCAQNNEKKKLGVSRYTTQKNRRNTPTRLELKKFCSYCNKHTIHKEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROC_TROW8
Sequence: MLRWFTAGESHGMELVAILEGLPAGIPVSLEHIGNELSRRRLGFGRSARQKFEKDLVTLSAGVLHGSTLGSPVAIRITNSEWGKWEKIMTPEVPCKSDMSDAKRAQGLYKPRPGHADLVGMQKYGFQNSRLVLERASARETAARVACGAVAKAFLQQLDIFILSHVKQIGSIKIDYEQGAYPRFCDLEAIDSSPVRCFDKNTSEKMKDELHRIKRCGDTLGGVFEVLAYGLPPGLGSYVHWDRRLDAMLSAAIMSIQAVKAVEIGDGLAISALPGSEAHDQIVLESGLLTRMSNHSGGVEGGVTTGSALRISGSMKPISTVPRALKTVDISTRQPANADHQRSDICAVPAAAVVGESMVALTISCAILDKFGGDSLCEIKRNFSGYLNSIPKNLMSVIER
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: OLHYD_MACCJ
Sequence: MYYSNGNYEAFARPKKPEGVDNKSAYLVGSGLASLAAASFLIRDGQMKGENIHILEELDLPGGSLDGILNPERGYIMRGGREMENHFECLWDLFRSVPSLEVEDASVLDEFYWLNKEDPNYSKCRVIENRGQRLESDGKMTLTKKANKEIIQLCLMKEEQLNDVKISDVFSKDFLDSNFWIYWKTMFAFEPWHSAMEMRRYLMRFIHHIGGLADFSALKFTKFNQFESLVMPLIEHLKAKNVTFEYGVTVKNIQVECSKESKVAKAIDIVRRGNEESIPLTENDLVFVTNGSITESTTYGDNDTPAPPTSKPGGAWQLWENLSTQCEEFGNPAKFYKDLPEKSWFVSATATTNNKEVIDYIQKICKRDPLSGRTVTGGIVTVDDSNWQLSFTLNRQQQFKNQPDDQVSVWIYALYSDERGERTNKTIVECSGKEICEEWLYHMGVPEEKISALAAECNTIPSYMPYITAYFMPRKEGDRPLVVPHGSKNIAFIGNFAETERDTVFTTEYSVRTAMEAVYKLLEVDRGVPEVFASVYDVRILLHALSVLNDGKKLDEIDMPFYERLVEKRLLKKASGTFIEELLEEANLI
What is the function of this protein?
Catalyzes the hydration of oleate at its cis-9-double bond to yield 10-hydroxyoctadecanoate.  Cannot catalyze the reverse reaction.  Is not active with saturated fatty acids and trans-, cis-5-, cis-6-, cis-8-, cis-11-, cis-13-, cis-14-, and cis-15-double bond unsaturated fatty acids as substrate; is only active on cis-9- and/or cis-12-double bond of unsaturated fatty acids without any trans-configurations, producing 10-hydroxy and 10,13-dihydroxy fatty acids.  The hydration of unsaturated fatty acids is suggested to be a detoxification mechanism and a survival strategy for living in fatty acid-rich environments.
What are the official names of this protein?
Oleate hydratase, Fatty acid double bond hydratase, Fatty acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the oleate hydratase family.
Protein: RL36_BACCR
Sequence: MKVRPSVKPICEKCKVIRRRGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RIBB_METTH
Sequence: MEIVIMIQEALKALRRGEIVLVFDADNRERETDMIVAAEKIKPEHIRIMRNDAGGLICVPVSWENSEKLGIPYMTDIMEEASGRYPVLGKLSPHDIPYDEKSAFSITVNHRKTFTGITDNDRALTIGELAGICRDDRHESFGDLFRSPGHVTLLRAADGHVLRRGGHTEMSIALMEMAGLTGVAVCCEMMDDRTGNSLSTEDAMKYAREHDLIFMSGAELIESYMEFRS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: ATP5H_HUMAN
Sequence: MAGRKLALKTIDWVAFAEIIPQNQKAIASSLKSWNETLTSRLAALPENPPAIDWAYYKANVAKAGLVDDFEKKFNALKVPVPEDKYTAQVDAEEKEDVKSCAEWVSLSKARIVEYEKEMEKMKNLIPFDQMTIEDLNEAFPETKLDKKKYPYWPHQPIENL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
What are the official names of this protein?
ATP synthase subunit d, mitochondrial, ATPase subunit d, ATP synthase peripheral stalk subunit d.
What is the protein family that this protein belongs to?
Belongs to the ATPase d subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: RPOZ_PHOLL
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQLQTGGKDPLVAEENDKVTVIALREVEEGLINGKILDVRERQEQQEQEAAEMQAVSAIAESRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: METE_LISMO
Sequence: MVKAISSNLGYPRLGEKREWKRALEKFWNGAISEEELLAETKALRLHALKKQQEKGIDLIPVGDFSFYDQVLDTSVTFGIIPKRFQHDGGKVSLNTYFDIARGKSDAVASEMTKWFNTNYHYIVPELADADPKVLDNRALYYYEEAKKELGIEGKPVLVGPVTYLKLGKGNDAENFEALLDKFIPAYVEILKELERAGAKWVQIDEPYLATSFDKSEIKLFEKVYQAFQTAVPNLKIELQTYFESLDYYEEVVNLPVAAIGIDFVHDHGDSLEALKAHGFPEDKYLAAGVIDGRNVWRSDLDAKLSLLTEIADYVTDGKLIVQPSNSLLHVPVTKLSEPDLDEVILGGLSFADQKLDEIAILTKALTDGAESVTAELEDARAAVTALNESSHRNNLEVQEAIANLGNVRVDRELPFAERIKLQHAWLNLPLFPTTTIGSFPQSPEVRKTRADWLKGNITDAEYNAFIEKETARWIKIQEELDIDVLVHGEFERTDMVEYFGQKLAGFQATKFGWVQSYGSRAVRPPLIYGDVAFTEEITVKESVYAQSLTKRPVKGMLTAPVTIINWSFVRDDVPESVVANQVGLALRKEVEALERNGIKVIQVDEPALREGLPLKQARWEKYLNDAVYSFKLTTASVQNDTQIHTHMCYSDFDDIIDTISALDADVISIETSRSHGEIISTFEEVTYDKEIGLGVYDIHSPRVPTVTEIQDNIRRALRAIDAKQFWINPDCGLKTRKEPETIAALQDMIKATKEVRAEYQVLEK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: PHOB_SHIFL
Sequence: MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIKMQGLSLNPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF
What is the function of this protein?
This protein is a positive regulator for the phosphate regulon.  Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
What are the official names of this protein?
Phosphate regulon transcriptional regulatory protein PhoB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IR75A_DROSE
Sequence: MQLVQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAEQFMKPIHPILVYHQFVQMRGVLNWSHLELNYMGHTQPTLAIYVDIKCDQAQDLLEEASREQIYNQHYHWLLVGNQSELEFNDLFALFNISIDADVSYVKEQIQDNNDSVAYAVYDVYNNGKIIGGQLNVTGSHEMSCDPFKCRRTRYLSSLQKRSKYGNREQLTDVVLRVATVVTXRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLYCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTASPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMQQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAEQGVLRVKANPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEKLLYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCEAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRPLTIHP
What is the function of this protein?
Olfactory receptor for propionic, butyric and 2-oxopentanoic acids.
What are the official names of this protein?
Ionotropic receptor 75a.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein: CLPS_GLOVI
Sequence: MSTETLERKSVQRKPMPLYKVLLHNDDHTPMNYVIEVLMKTIPKMQPSKARKIMLEAHNGGVAVVIVCALEHAEFYSESLNRHNLTSTYEPDC
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: GET4_MOUSE
Sequence: MAAAAAMAEQEGARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHAEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVDVADELLENLAKVFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKNSALVVFTTYTQKHPSIEDGPPFVQPLLNFIWFLLLAVDGGKLAVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEEGEESQDDSSPIELD
What is the function of this protein?
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.  The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.  Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum.  Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome.  Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum.  The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome.  It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
What are the official names of this protein?
Golgi to ER traffic protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the GET4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CANB1_BOVIN
Sequence: MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
What is the function of this protein?
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.  Confers calcium sensitivity.
What are the official names of this protein?
Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.