PharMolix/UniProtQA huggingface dataset:
Protein: CNI1_CAEEL
Sequence: MAFTFAAFCYLLALIAVGFCIFFAIYTVICVDELRTDYKNPIEQCRNLNQLILPEYIIHGTFTVLFIFSWQLISILANLPLAFYHIYTYAKRPVMSGPGIYDPTTILNRSTLSSTLRISWIKLAFYLVSFFYYLYAMIYTLVTSN
What is the function of this protein?
Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses.
What are the official names of this protein?
Protein cornichon homolog 1.
What is the protein family that this protein belongs to?
Belongs to the cornichon family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite.
Protein: MLC1_MACFA
Sequence: MTQEPFREELAYDRMPTLERGRQDPASYAPDTKPSDLQLSKRLPPCFSPKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIMSARSSEEYCKKKKGSMSDGTNILGEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSVMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQSGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ
What is the function of this protein?
Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
What are the official names of this protein?
Membrane protein MLC1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Protein: RL5_PSEF5
Sequence: MARLKEIYRKEIAPKLKEELKLSNVMEVPRVTKITLNMGLGEAIGDKKVIEHAVADLEKITGQKVVVTYARKSIAGFKVREGWPIGVKVTLRRERMYEFLDRLLSISLPRVRDFRGLNAKSFDGRGNYSMGVKEQIIFPEIDYDKIDALRGLDITLTTTAKNDDEGRALLRAFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: FCAMR_MOUSE
Sequence: MDQGAPAKPSEQKVPSLRTRWEILLLTLCLLHGSSMTPPHRRSHSRWLQAGSPQFRTHLYNVEAHTAPTPLCCWKNSLSGTNALRGPRLVTGNTGGAVTIHCHYAPSSVNRHQRKYWCRLGSPLWICHTVVSTNQYTHPDYRGRAALTDIPQSGLFVVRLLRLSLGDVGLYRCGIGDRNDMLFFSVNLTVSAGPSNTTYAAAPASGEPTTASPGAASSAGNGWTSGITQILEGSGSEWDRTVPTTGTSKTTSSANGRQTLRTARTMVPGTGSREEGSIRAAVPTPEGPSPKSRSMSSTTQGVWLWSTRNSVTPSVTTSEGRRQGTTPETDGPRDETDVRVSPEAPRKTTGTTRPSALISEHVTWETLQDKTEVSKQQMLHSLEELSPAPSAQTLNATCLEVASEEGRSIDGSLENTTEESSPPTPSQLSVAGPVWVSVKGPSMKSALMEGESHTRILTPVSTVLALLLIAALILLKRSLGRQRTSQKKERVPRITLIQMTHFLPDKLPDEGKNFQQSNLLPPQASLTVLENDPRP
What is the function of this protein?
Functions as a receptor for the Fc fragment of IgA and IgM.  Binds IgA and IgM with high affinity and mediates their endocytosis.  May function in the immune response to microbes mediated by IgA and IgM.
What are the official names of this protein?
High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor, Fc alpha/mu receptor, mFcamR.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CRTO_STAAE
Sequence: MKTMKKYIKTAFFCSMYWLIVQLNIANLGTRIPDKYFRQKYIIFKSFNFEKHGKFWNKWFYVRKWKHKILDGHQLNQNIYDQRHLMTINTDEIEKMIIETKRAELIHWISILPVIIFNKGPRLVKYINIFYAMIANVPIIIVQRYNRPRLTQLLRILKRKGERHD
What is the function of this protein?
Catalyzes the acylation of glycosyl-4,4'-diaponeurosporenoate, i. e.  the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12-methyltetradecanoic acid, to yield staphyloxanthin.  This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains.
What are the official names of this protein?
Glycosyl-4,4'-diaponeurosporenoate acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase CrtO family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: APOA1_ODORO
Sequence: MKAVVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDVVKDGGRDYVAQFEASALGKQLNLKLLDNWDTLSSTVAKLREQIGPVTQEFWDNLEKETEVLRQEMNKDLEEVKKKVQPYLDEFQSKWHEEVELYRQKVAPLGAELSEGARQKLQELQEKLSPLGEELRDRARTHVDALRAQLAPYSDQLRERLATRLQALKEGGGAALAEYHAKASEQLSVLREKAKPALEDLRQGLLPVLESFRTSLLAAVDEATKKLNAQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility.
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: XBP1_BOVIN
Sequence: MVVVAPAQSPAAGAPKVLLLSGQPAATGGAPAGRALPVMVPGQQGASPEGASGVPPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVTEEEAETKGNGAGLVAGSAESAALRLRAPLQQVQAQLSPLQNISPWTLMALTLQTLSLTSCWAFCSTWTQSCSSDVLPQSLPAWSSSQKWTQKDPVPYRPPLLHPWGRHQPSWKPLMN
What is the function of this protein?
Acts as a weak transcriptional factor.  Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress.  Binds to the ER stress response element (ERSE) upon ER stress.  Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences.  Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner.  Binds to the CDH5/VE-cadherin gene promoter region.
What are the official names of this protein?
X-box-binding protein 1, XBP-1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner. Colocalizes in the nucleus with SIRT1. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Shows no preferential localization to either the nucleus or the cytoplasm. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane.
Protein: GATD_PYRAE
Sequence: MYKKVRVVLENGDVFEGVMLPPTQFSDSDIVVLKLKNGYNVGFKKGRIKEIVELGEVQTAPLSAKPMPKIEGEKVWLLATGGTILSRVDYVTGGVYPTLSVDYLFEVLGGLEAPIEAEEVTAKFSEDMTPALWGVIAERVAEAFKKGARGVVVLHGTDTMQYTAAALAFAFKSAPGPIALVGAQRSSDRPSTDAVLNLKAAIAVTARAPFAESVVVMHKTSGDTVVAVHRGTRVRKMHTSRRDTFQSINTTPIAEYYPEKELLQVLTDVYKERGGLDYTAKFEEAVALVKFYPGMHPRLLEALLEVGMKGVVIEGTGFGHVGEGVLPAVKKLIDAGVIVAMTSQTLYGRVNLYVYRRGRELLSMGVIPLEDMLPETAYAKMSWALANFKREEVPRVLTTPIAYEMSPRSDPLVFGGL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: A7L3B_MOUSE
Sequence: MEEISLANLDTNKLEAIAQEIYVDLIEDSCLGFCFEVHRAVKCGYFYLEFADTGSVKDFGIQPVEDKGACRLPLCSLPGDPGDGPQTELQRSPPEFQ
What is the function of this protein?
By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22.  Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction.  Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3.  Affects protein expression levels of ENY2 and ATXN7L3.
What are the official names of this protein?
Ataxin-7-like protein 3B.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_VEREI
Sequence: MTTQQTVKIQLVRSPIGTKESHRATVRGLGLRKLNSVSQLQDTPEVRGMINKISYLLKVL
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RS7_HALH5
Sequence: MPRKGPVARRDVLPDPIYNSKLVTRLINRIMVDGKRGIAQKILYNAFELVRERSGKDPMEVFDQALKNIMPVLEVKARRVGGANYQVPVEVKPERRTTLGLRWLVNYSRLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GATB_THEPX
Sequence: MKYEAVIGLEVHAELLTESKIFCGCTTKFGGEPNTHVCPVCLGLPGTLPVLNKKVVEYAVRAGLALNCTIANFSKMDRKNYFYPDLPKAYQISQYDLPLCSNGYVEIEVDGKVKKIGIKRIHIEEDAGKLLHENTDGSLVDYNRAGVPLIEIVSEPDMSTPEEAYQYLTKLKSILEYTEVSDCKMQEGSLRVDTNVSVRPVGSTELGTKIELKNLNSFRAVQKALEYEIKRQIKVLEEGGTIVQETRRWNEAKGITEPMRTKEEAHDYRYFPEPDLVPIIVTDEWKEEIRKSLPEMPHRKRERFISEYGLPEYDAKIITSSKKIADFFEKCALEYDSPKAVSNWLMGEFSRLMNETGKEIDEVPVTPQMLVKLLKLIDNGVISGSIAKTVFEEMFGTGKEPEVIVEEKGLKQIANEDELREIIKKVIAENPKSVEDYKNGKEKAMGFLVGQVMKATKGKANPQLTNQILKEELSK
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: IHFA_MYXXA
Sequence: MTKADIIEGVYEKVGFSKKESAEIVELVFDTLKETLERGDKIKISGFGNFQVRQKKARVGRNPQTGKEIEISARRVLTFRPSQVLKSALNGEAPPEDHAEIDAREEAAADAAEARGEDFDEEGMEDMEG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.  It is necessary for normal cell growth and the production of carotenoids in response to light.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: GLND_HAEI8
Sequence: MLFSPTLSSPLTPSAVKIERENLKQFELENFSRYSIFELIENRCDFYDALLIQLWQEIELSEQLGIALIAVGGYGRREMFPLSDLDFLILVEQTPSPEIEEKITQFIQFLWDCGFEVGNSVRTLEQCESEGKQDITIATNLLEARFLAGNRPHFDALNELVKRADFWSKEDFFNAKVQEQIERYQRYHNTAYNLEPDIKYSPGGLRDLHLLYWVALRHSGALTLEAILQSGFIYPQEYQQLQESRAFLFKVRFALHLILKRYDNRLLFDRQIKVSELLGFRGEGNPAVEKMMKCFFQALHRISLISNLLIQHYRENVLPSNQDTVIDQLDDDFQLINQCLCLRNSFVFQEKPARILDLFFYLTQYEHANIHSDTLRQLQISLDQLSQKLCEIPAAREKFLRLFNQPNAIKRAFMPMHQYGVLTAYLPQWQAIEGLMQFDLFHIYTVDEHTLRVMLKLESFLSQESAQEHPIAHRIFSQLSDRTLLYIAALFHDIAKGRGGDHAELGAVDIADFAQLHGLDRREIDTLAWLVKSHLLMSITAQRRDIHDPEVVMNFAEAVQNQVRLDYLTCLTVADICATNGNLWNSWKRSLFASLYEFTGRQFSQGMKELLDYSEKSAENRKLAQQILMRDYSDITPISIEQLWARCPEDYFVRNTPKQIAWHTSLLVDFVEALLVKISNRFSLGGTEVFIYCQDQPHLFNKVVSTIGAKKFSIHDAQIITTQDGYVFDSFIITELNGELVEFDRRRELEQALTLALQSEKLPALSIVPNRQLQHFTVQTDVRFLQENKKEHTQMELVALDKAGLLAQVSQIFTELNLNLLNAKITTVGEKAEDFFILTNQFGQALDSQQREILRNVLYRNIG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: PROA_RHIL3
Sequence: MLDTVAPGPDIDVLMNDIGRKAKAAARPLGFASTEAKNSALNAMADAILANKAHILAENAKDLKDIEGTEMLASFVDRLTLNDKRVAEMAEGIRAIAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSDSRRSSQAIHACLVKGLKAAGLPEHAIQLVPVTDRAAVGAMLRGLDGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGLCHIYVDASADIEMAKKIIVNAKMRRTGICGAVETLLVDGAAIGTHLTPLLEALTDAGCEIRASPTVLKVAPGMKPATEEDWSTEYLDAIISVAVVDGISGAIAHIQTYSSNHTEAVIAEDPDVVARFFTEVDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVHGAGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3E_NEUCR
Sequence: MASTSPATTNGDVAPANYDLVLKLAPHLDRHMIFPLLEFNAGRLKEDETDKAREILAAKYALLKKTNMTDYVANLYCELEGLKEPPAEYAERRQKVFHQLEKYEQETAKITELLQRDDVVNNLRSDKVANLEFLKKEHDVTIDMVNALYDFGQLQYSCGNYADASELLYRFRVLSTDNDKVSYATWGRLACEILTMNWESAMEELQKVRESIDTRLANNPLAQLQHRTELVHWALFPLFNYDKAREPLLDLFFNAGFINTIQANSPWILRYLTVAVITNRGRAKNAGVHQKQMKDVVRIVKQEAYEYQDPITRFVHALCIDFDFEEAQQQLVLAEEVLRSDFFLLAHADDFVDSARHLIFESYCKIHARISLKDLSARLGLNNDDAEKWIVNLIRDTRLDAKIDYKEGTVVMNHPPSSVYQQVIERTKGGFFRTQVLTAAVAR
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISH1_SCHPO
Sequence: MRSRSVASLGVLLAIVFYIFTYGFSTYRKNDTSAVKTWLEEHSIPYGSRSSPSDFQQFISESYDSLVPNLDKWSGHNLNSWLGKKTESSYLDAISNKIRKTGRKLSGSVEDARDATQEAWESQKASLFESWSDSQLRAFLARHSPQFAAKEKKGILEKLSPASLRETAAKEYDALTSKLGNTGDWIYDTWSDNELRTWLHDVGVPISSHESTRSHLLRKLKNYISTKADEAQPSVEAVKGKASEKAKQAGEFVSDKAGDAKELVNEKSSEAGQYAGQKMEEGGELLQEISKRRGRFGNWWANSGLKAYFDAHGIPAYQPSPIDQFYAHLRRQYYLKTNGYQALKSKAYEEASNVADSASSIASNVASGATEAYQGAASGASRFTEGAKTAAESVTSAFEHNKDTATSKAKQMKGKAASLGSTASEKVGEAADYAAETASKVASKAASKVRETIDETIIERWQDSKLKEFLFLRGVPVPQRSTKDQLLDLVRKHFNKGAVPNWAAYFDTLSSKELSAWIKEYKKHYHGKLHPSKDREHLFQNACNIYRAIAEKADKSVLQSIQSKFPKATVPGYDSWSNEDLKSALKEYGDSIGKVFNRKDAIERLKRHDILFYGPVVADKAKSGVSGFLRRVASFMGFGTRDVAEIKLGENIQKVKDTASKASSAVSSAGDYVETNVKKAQRVL
What is the function of this protein?
Has a role in maintaining cell viability during stationary phase induced by stress response.  Activated by the spc1 MAPK pathway.
What are the official names of this protein?
Stress response protein ish1.
Protein: CLP1_CANAL
Sequence: MSIPGFGSAEKVNHTASSVTLTIPQSYEWRIEVPFNRILKFKVLTGIVEINGTELANNTEIQLSGTKTYLYSPVTDAVIEYVLVENKDDLSLVSASDEGFVEYLSDESNMDSILNLHMYLESKRQYTKDYNFSSSIDQQQSGPKVLIIGSKYSGKTTVSKILSAYANKMNNTPVLVNLQPRDGVFALPGSLTATPISDSFDVESCNGYGLTTTSGTLVHNPKQPIVKNFGMADFNDNVDFYKLLIEKLGIAVLSRLDQDLNIKNSGVIIDTPALTSKNFDIVESMVSNFLIDNIIVIGNERLAIELTKKFAYKSTQLNIIKLNKSSGCIEVEDRFIRLQQEQTIKEYFNGNFKTRLSPFKTDIELSGLKIYKNVLTKDLLSQMAFLPGGDDFEKDETNPEEDPEKKQLEKYYQAIEDPNSSNLENSIVAITHLPNNDKKLGKDLLNTSVLGYIHVSKFDDQKKRLKVLFPFPGVFPKNVLISTNIGYNE
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor CLP1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PMGE_MACFA
Sequence: MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYNITPPPIEESHPYYHEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTVLISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK
What is the function of this protein?
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG).  Also exhibits mutase (EC 5. 4. 2. 11) activity.
What are the official names of this protein?
Bisphosphoglycerate mutase, BPGM, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, BPG-dependent PGAM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: PENK_MESAU
Sequence: MARFLRLCTWLLVLGSCLLATVQAECSQDCAKCSYHLVSPGDINFLACTLECEGQMPSHKIWETCKDLLQVSKPEFPCDSINMFKDSNKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKKYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAREGRHQESTDNDDNMSKRYGGFMRGLKRSPQVEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEAESYSKEVPEIEKRYGGFMRF
What is the function of this protein?
Increases glutamate release in the striatum.
What are the official names of this protein?
Proenkephalin-A.
What is the protein family that this protein belongs to?
Belongs to the opioid neuropeptide precursor family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.
Protein: RL3_PSET1
Sequence: MALGLVGRKVGMTRIFTEDGVSIPVTVIEATPNRIAQIKSEATDGYNALQVTAGTKKASRVNKASAGHFAKAGVEAGRGLWEFRLNGGEGDFEVGAELTVELFNEINKVDVTGTSKGKGFQGGVKRWNFSMQDATHGNSLSHRAPGSIGQNQSPGKVFKGKKMAGHMGAERVTTQNLELVRVDAERNLLLVKGAVPGAIGGDVIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: DCR1B_RAT
Sequence: MNGVVIPQTPIAVDFWSLRRAGTARLFFLSHMHCDHTVGLSSTWARPLYCSPITAHLLHRRLQVSKQWIRALEIGESHVLLLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQEATQQIIQLIRQFPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHMEICHSAMLQWNQTHPTIAIFPTSRKIRSPHPSIYSIPYSDHSSYSELRAFVAALRPCQVVPIVREQPCGEFFQDSLSPRLSMPLIPHSVQQYMSSSSRKTNVFWQLERRLKRPRTQGVVFESPEEKADQVKVDRDSKKHKKESLSPWAGCLSRLCPHPLQARKQLFPDFCRKEGDEPVLFCDSNKMATVLTAPLELSVQLQPVDEFPFPETREEIGLGSPLWSGGGSGSPTRGKQSNGMGCGSPPTHISRTTHLTPESGGLALKYLLTPVDFLQAGFSSRNFDQQVEKHQRVQCNNPAVMNTVDDV
What is the function of this protein?
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase.  Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse.  Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways.  Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology.  Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation.  In case of spindle stress, involved in prophase checkpoint (By similarity).  Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity).  Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity).
What are the official names of this protein?
5' exonuclease Apollo, Beta-lactamase MBLAC2, DNA cross-link repair 1B protein, SNM1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome (By similarity).
Protein: PVK2_TYRGL
Sequence: SGLQFAVLDGQGFLPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
CAPA-Periviscerokinin-2, CAPA-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FABZ_BUCBP
Sequence: MYNSNITDITTLLPHRYPFLLIDRIIAYQKNFNILTIKNISYSEFCFTGHFYKNPVFPGVLILEAIAQSACLLVYKSFGMSYKNNLFYLTNIIDVKFKKKVIPGDQMLINVFVDKHHHRLIRFVGHVSVSKYIVCKATISCLLTNDVVSR
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.