PharMolix/UniProtQA huggingface dataset:
Protein: ACPS_BRADU
Sequence: MIIGIGSDLIDITRVGKVIERHGERFLDRIFTAAERAKAERRAKNEKMVVATYAKRFAAKEACSKALGTGIRRGVWWRDMGVVNLPGGRPTMQLTGGALARLQALTPDGFEARIDVSITDDWPLAQAFVIISAVPLAKS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB_HALMD
Sequence: MSKFPDLPGMKNLDANPYEPELASFDDMDADAGDGDAVAKTGTTTIGITTDGGVVIATDMRASLGGRFVSNKSVQKVEQIHPSAALTLVGSVGGAQSFIRTLRSESDLYEVRRGEPMSISALATLAGNFARGGPFFAINPILGGVDEEGSHVYSIDPAGGVMEDDYTVTGSGMQVAHGKLEDRYHDDLSMEEAEELAVEAVYAATERDTGSGNGVYVATVTGDGVDITGYDDFEGAR
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPED_YERE8
Sequence: MSKLKLHGFNNLTKSLSFCIYDICYAKTADDRDGYIAYIDEQYNANRLTEILTETCSIIGANILNIARQDYDPQGASVTILVSEEPVDPRDVDTSEHPGPLPSAVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTMDYRVRGFTRDINGVKHFIDHKINSIQNFMSDDMKSLYHMMDVNVYQENIFHTKMMLKDFDLKHYLFNAKPEELSAEERERITHLLYKEMQEIYYGRNVPEV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: RCC1_MESAU
Sequence: MPPKRIAKRRSPPEDAIPKSKKVKVSHRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVCLNQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDMPVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLKSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDKEQS
What is the function of this protein?
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis.  Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis.  Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (By similarity).  Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:2300055, PubMed:2022190).  Binds both to the nucleosomes and double-stranded DNA (By similarity).
What are the official names of this protein?
Regulator of chromosome condensation, Chromosome condensation protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Predominantly nuclear in interphase cells. Binds to mitotic chromosomes.
Protein: PDXB_PSEP1
Sequence: MLIVADENIPLLDAFFQGFGEIRRYPGRSLDAASVKDADILLVRSVTKVDRQLLEGSRVRFVGTCTIGTDHLDLDYFAEAGIRWSSAPGCNARGVVDYVLGSLLTLAELDGVALPERVYGVVGAGEVGGRLVRVLHGLGWKVLVCDPLRQAAEGGDYVSLETILQQCDVISLHTPLQRGGQHPTWHLLGQAQLAQLRPGAWLVNASRGPVVDNVALRELLLDREDVHAVLDVWEGEPQVDLTLADLCTLATPHIAGYSLDGRQRGTAQIYQALCRFLGVNEQVRLAELLPKPPLAQIELDASTDLSWALATLCRAVYDPRRDDADFRRSLSDDPQQQRAAFDQLRKQYPQRREIEGLAVRLHGEAPQLAQLVSALGGVLV
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL92_ALHV1
Sequence: MFERGDQGSMHQKRRGPGAHQCYFTKMITMATTFHTVDNIFVCTECKTYHVCDGGEDCYLVNMGEGLVCELTGRCAVNSVSFGNPRPMSPVIYPHHNTPGPNQFLDSVVQCVQRDVAIYLSSSSYEEVKDKVLLCQGELREEVADLIKTTFNHCQNIFQSAQCAYSLICSIYIHVIISVYSSKTVYGNLIFKCTKNKKFDSVAKSIRQAWMSILTTGDTFTTAVM
What are the official names of this protein?
Gene 31 protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
Protein: ATP6_HALGR
Sequence: MNENLFASFTTPTMMGLPIVILIVLFPSILFPSPDRLINNRLTSIQQWLIQLTSKQMLSIHNHKGQTWALMLISLILFIGSTNLLGLLPHSFTPTTQLSMNLGMAIPLWAGTVITGFRHKTKASLAHFLPQGTPLPLIPMLVIIETISLFIQPMALAVRLTANITAGHLLIHLIGGATLALMDISTTTAFITFIVLILLTILEFAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: H4_TIGCA
Sequence: MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CRCB_SOLUE
Sequence: MKYLLIALGGGTGSLARYLLGTAITSRVGARFPIGTMVVNVSGCFAIGLAMTLLTERLQPHPYWRLALVVGFLGGYTTFSSFEWETYAAVREGGFWIGLANVLGSVTLGYAAVWFGALLARR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYH_SALA4
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGAEVFGLQGPDIDAELIMLTARWWRALGIADHVSLELNSIGSLEARANYRDALVAFLEQHQETLDEDCKRRMYTNPLRVLDSKNPDVQALLNDAPALGDYLDDDSREHFAGLCKLLDAAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFIASPVVDIYLVAAGAQTQSAAMTLAERLRDEMPGVKLMTNHGGGNFKKQFARADKWGARIALVLGESEVADGTVVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CAMJR
Sequence: MKYTEIKDKTAAELATMLKEKKVLLFTLKQKLKTMQLTNPKEISQVKKDIARINTAINALR
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: HSP74_ANOAL
Sequence: MPSAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFSDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRKFDDPKIQADMKHWPFTVVNDGGKPKIRVEFKGERKTFAPEEISSMVLTKMKETAEAYLGQSVKNAVITVPAYFNDSQRQATKDAGAIAGLNVMRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRMVGHFVEEFKRKHKKDLSKNARALRRLRTACERAKRTLSSSTEATIEIDALMDGIDYYTKISRARFEELCSDLFRSTLQPVEKALSDAKMDKSSIHDIVLVGGSTRIPKVQSLLQNFFAGKSLNLSINPDEAVAYGAAVQAAILSGDKDDKIQDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQTQIFSTYADNQPGVSIQVFEGERAMTKDNNLLGQFDLSGIPPAPRGVPQIEVTFDLDANGILNVAAKEKSTGKEKNITIKNDKGRLSQADIDRMVSEAEKFREEDEKQRERISARNQLEAYCFNLKQSLDGEGASKLSDADRKTVQDRCEETLRWIDGNTMADKEEFEHKMQELTKACSPIMTKLHQQAAGGPSPSSCAQQAGGFGGRTGPTVEEVD
What are the official names of this protein?
Heat shock protein 70 B2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: WHIA_RHOOB
Sequence: MAMTAEVKDELSRLVVTHVSCRKAEVSSLLRFAGGLHIVGGRVVVEAEVDLGSTARRLRREIFDLFTYSADVHVLSAGGLRKSSRYIVRVAKEGEALARQTGLLDLRGRPVRGLPAQVVGGSVADAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGISAKAREVRGTDRVVIRDGEAIGALLTRMGAQDTRLVWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALDILGDEVPDHLAAAGHLRVEHRQASLEELGQLADPPMTKDAVAGRIRRLLSMADRKAKETGIPDTESAVTADLLDDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: BETI_BURCJ
Sequence: MPKVGMREIRRAQLIDATLRSIDEAGLPGTTLASVAQRANISTGIVSHYFGDKDGLLEATMRHVLRDLWSATTRRRVAARKDPRSRLRAVVAANFDDTQVSAPVMKTWLAFWSQSMHDPMLKRLQHVNTRRLHSNLCAEFAKALPRTKAREAASGLAALIDGLWLRGALAGGPIDTRAALKLAHDYIDLLLASD
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: APOA4_HUMAN
Sequence: MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
What is the function of this protein?
May have a role in chylomicrons and VLDL secretion and catabolism.  Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT.  Apoa-IV is a major component of HDL and chylomicrons.
What are the official names of this protein?
Apolipoprotein A-IV, Apo-AIV, ApoA-IV, Apolipoprotein A4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAJ_XYLFA
Sequence: MSKRDYYQVLGVPRTASEDDLKKAYRRCAMKYHPDRNPGDAAAEAAFKECKEAYEVLADTKKRKLYDTHGHAAFEHGVGGGNAPDMNDIFGDIFGNIFGGARASRRGADVGYMVELDLEEAVAGVERQIQIPTLVECTHCHGSGSEDGHVETCGTCRGSGQVRIQRGIFAMQQTCPHCGGRGVIIRNPCKVCNGAGRVEDHKTLSVKIPAGVDNGDRIRLSGEGEQGPEGVPPGDLYVEVRVREHPIFQRDGDDLHCEVPVRISQAALGDIVRVATLDGEAEIRIPAETQSGKLFRLRGKGVRSVRSRTEGDLYCRIVVETPVNLTAEQRKLLEQFEMTFAGEDARKHSPKSATFLDGVKSFWDRMTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOAH_ECO55
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: DPP11_POREA
Sequence: MNKRFFPTLLLAFVCSTLAYADGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCTGVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGLEVEIVDEITDVTAAVKKELERIKKPSGLEFLSPRYLSSLAPEIVGKKAASRPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAWPRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNAQGVKEGDFALIMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKINIMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIATTEEAVRAISKAIEGRQDLRMRQRYLLEGILMGIEMSNAPAADSDIADHWDDPARREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEKQPISIREGIAEYGSAKAYVEMIFDKSIYASRERFEEFMKNPDRDRLLRDPMSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDANLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKALYEAKNYGRYANSDGSMPVNFCATTHTTGGNSGSPVMNARGELIGLNFDRNWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQF
What is the function of this protein?
Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.  Shows a strict specificity for acidic residues (Asp or Glu) in the P1 position, and has a hydrophobic residue preference at the P2 position.  Is likely involved in amino acid metabolism and bacterial growth/survival of asaccharolytic P. endodontalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.
What are the official names of this protein?
Asp/Glu-specific dipeptidyl-peptidase, Dipeptidyl-peptidase 11, DPP11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S46 family.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Is observed in both cell- associated and soluble extracellular forms.
Protein: GR10B_DROME
Sequence: MRVGKLCRLALRFWMGLILVLGFSSHYYNPTRRRLVYSRILQTYDWLLMVINLGAFYLYYRYAMTYFLEGMFRRQGFVNQVSTCNVFQQLLMAVTGTWLHFLFERHVCQTYNELSRILKHDLKLKEHSRFYCLAFLAKVYNFFHNFNFALSAIMHWGLRPFNVWDLLANLYFVYNSLARDAILVAYVLLLLNLSEALRLNGQQEHDTYSDLMKQLRRRERLLRIGRRVHRMFAWLVAIALIYLVFFNTATIYLGYTMFIQKHDALGLRGRGLKMLLTVVSFLVILWDVVLLQVICEKLLAEENKICDCPEDVASSRTTYRQWEMSALRRAITRSSPENNVLGMFRMDMRCAFALISCSLSYGIIIIQIGYIPG
What is the function of this protein?
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
What are the official names of this protein?
Putative gustatory receptor 10b.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOB_BUCBP
Sequence: MKYTLTRVNISDDDQNYPREKKIQVSDPTKKYIQKNVFMGTLSKVLHNLVNWGRKNSLWPYNFGLSCCYVEMVTSFTSVHDISRFGSEVLRASPRQADFMVIAGTPFIKMVPIIQRLYDQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPVDVYIPGCPPRPEAYIHGLMLLQKSISKERRPLSWIIGEQGIYKANFNSEKKNLRKMRNLVKYSQDKN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDRP2_ARATH
Sequence: MNFISDQVKKLSSSTPEEPDHNKPVEGTETATRPATNAELMASAKVVAEAAQAAARNESDKLDKGKVAGASADILDAAEKYGKFDEKSSTGQYLDKAEKYLNDYESSHSTGAGGPPPPTSQAEPASQPEPAAKKDDEESGGGLGGYAKMAQGFLK
What is the function of this protein?
May be a negative regulator of the ABA signaling/synthesis pathway.
What are the official names of this protein?
Nodulin-related protein 2.
Protein: SECA_HYDCU
Sequence: MALNIFKKLFGSRNERLLKQYRKNVQQINALEEAFSQLSDDELKAKTDYFKSQISEGISLDRILPEAFAVVREAGKRVMGMRHYDTQLIGGMVLHEGKISEMRTGEGKTLVATLPAYLNALSGNGVHVITVNDYLAARDAEWMGQLYGFLGLTTGVVLSGQTSNEKQTAYNADITYGTNNEFGFDYLRDNMAIFAEERVMRGQNFAIVDEVDSILIDEARTPLIISGPAEDKSDLYQKMNPLVKGLEKGEEDLETKTSSGDYTIDEKSKQIHLTDEGHSKVEAMLVEVGLLEEGDSLYDAEHISLMKYVNASLRAHLLFEKNTDYIVQDNEVVIIDEFTGRKMSGRRWGDGLHQAVEAKEGVPIQAESQTYASITFQNYFRQYAKLSGMTGTADTEAGEFLSTYSLEVVVVPTNKIPQRNDLPDLVFLDIEGKLAAIVREVKEVVKTGQPILVGTASIELSEVLSSLFEKEGIPHSVLNAKQHEKEATIIAQAGRPGAVTIATNMAGRGTDIVLGGNLDMEIESLDNPTEAQIAQIKADWQIRHDEVVEKGGLMVIGSERHESRRIDNQLRGRSGRQGDPGVTRFYLSLDDDLMRRFASEKVKNMMRRLGMKSDEAIEHNMVTKSIERAQKQVERMHQDERANLLKFDNISNEQRKVVYAQRNELMEEENVSEIIDALRENVIETMMTGFIPPGSIEEQWNVAGLEKQLQEDLGLTFPISDWLQEDKGLFEEKLREKIIAEAKALYQNKMAVIDEKTRHHFEKEVLLRTIDKQWREHLNEMDYLRRWIHLKGFAQKDPFQEYRATAAEMFEAFLDEVMFETVQTLSMVQIQGADDVDAYEQQQIEERPQELEANHPAAKGISDAMNNAASDSETDSSDATYRRETPKVGRNDPCPCGSGKKYKQCCGKLN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: FOLD_LEVBA
Sequence: MTTIIDGKQIAKDLNAQTATRVAALKKRDIVPGLAVIVVGDDPASAIYVRNKHKKALKLGIKSVVRELPATTTQAELTQIVMAYNVDPTIHGILVQSPLPAGLDEQAIVAAIDPQKDVDGFHPLNVGRLFANLPGKYPVSCTPRGIMTMLATLPMHLRGKRAVVVGRSLIVGRPMAAMLLNADMTVSVAHVHTQHLSDLTRTADVLVVATGVTHLIKATDVKPGAVVIDVGMDRDENGKLTGDVDFDNVAPRVAAITPVPGGVGPMTIATLMQQTVDLCEWSEQRGNN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: NDHI_CAPBU
Sequence: MLPMITGFMNYGQQTLRAARYIGQGFMITLSHTNRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETNIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYEFSTYDRHELNYNQIALGRLPMSVIDDYTVRTILNSPQTKNGVNPLI
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ELO5_CAEEL
Sequence: MMDQILGTNFTYEGAKEVARGLEGFSAKLAVGYIATIFGLKYYMKDRKAFDLSTPLNIWNGILSTFSLLGFLFTFPTLLSVIRKDGFSHTYSHVSELYTDSTSGYWIFLWVISKIPELLDTVFIVLRKRPLIFMHWYHHALTGYYALVCYHEDAVHMVWVVWMNYIIHAFMYGYYLLKSLKVPIPPSVAQAITTSQMVQFAVAIFAQVHVSYKHYVEGVEGLAYSFRGTAIGFFMLTTYFYLWIQFYKEHYLKNGGKKYNLAKDQAKTQTKKAN
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids.  Condensing enzyme required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso), both play critical roles in animal development and growth.
What are the official names of this protein?
Elongation of long chain fatty acids protein 5, ELO-5, 3-keto acyl-CoA synthase elo-5, Long-chain 3-oxoacyl-CoA synthase 5, CEELO5, Monomethyl branched-chain fatty acid elongase 5, mmBCFA elongase 5.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GRPE_THEP1
Sequence: MSEKDKKELTQECEELKEKYKELEEYAKRLKAEYENYREEVAREKRELIKNANEYLILKLIPVLDDFERALNQGEKRDAFYEGVKMIYKKLLNVLEKEGLTKIHVGEKFDPFEHEAVERVETEDVEEYTVLEVVESGYKFHGKVLKPAKVKVAVKPRKKEAEKVEKPSDEKE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLF12_HUMAN
Sequence: MNIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV
What is the function of this protein?
Confers strong transcriptional repression to the AP-2-alpha gene.  Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
What are the official names of this protein?
Krueppel-like factor 12, Transcriptional repressor AP-2rep.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.