PharMolix/UniProtQA huggingface dataset:
Protein: RRF_SALTI
Sequence: MISDIRKDAEVRMEKCVEAFKTQISKVRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMGPAVEKAIMASDLGLNPSSAGTDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKAISEDDDRRSQEEVQKMTDAAIKKVDAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRU4_BRANA
Sequence: MGPTSLLSFFFTFLTLFHGFTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLYLPTFLNAGKLTFVVHGHALMGKVTPGCAETFNDSPVFGQGQGQEQGQGQGQGQGQGFRDMHQKVEHLRSGDTIATPPGVAQWFYNNGNEPLILVAAADIANNLNQLDRNLRPFLLAGNNPQGQQWLQGRQQQKQNNIFNGFAPQILAQAFKISVETAQKLQNQQVNRGNIVKVQGQFGVIRPPLRQGQGGQQPQEEGNGLEETLCTMRCTENLDDPSSADVYKPSLGYISTLNSYNLPILRFLRLSALRGSIHNNAMVLPQWNVNANAALYVTKGKAHIQNVNDNGQRVFDQEISKGQLLVVPQGFAVVKRATSQQFQWIEFKSNDNAQINTLAGRTSVMRGLPLEVISNGYQISPQEARSVKFSTLETTLTQSSGPMGYGMPRVEA
What is the function of this protein?
This is a seed storage protein.
What are the official names of this protein?
Cruciferin CRU4, 11S globulin, 12S storage protein.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum.
Protein: FLPA_AERPE
Sequence: MVEVVSVREHDRWRGVYVVELEDGSLRIATKNLVPGQRVYGERIFRYNGEEYREWNAYRSKLAAALLKGLIELPVKEGDRILYLGIASGTTASHMSDIIGPRGRIYGVEFAPRVMRDLLTVVRDRRNIFPILGDARFPEKYRHLVEGVDGLYADVAQPEQAAIVVRNARFFLRDGGYMLMAIKARSIDVTTEPSEVYKREIKTLMDGGLEIKDVVHLDPFDRDHAMIYAVMRR
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: YMC0_YEAST
Sequence: MVTTPLHSSPKSSLKSSTTSLRSVHTQSGRMGPSEPKHRTTKSWSIWGGNDEEEPELSNKNKGKETAQDNSQENDNVSNEGTRLHDNQQTTILKETTRIEKGEKDKKDRNAAIVEKNTRPRAWPFFWGRNKKDPEPTHNIPTDADNNTLSRLANSLNPAPLTNTYIPYKPDAILIRDKGVKTAKKLTDDIGNQFPNIVVPSFDILPKQTIWNTVTSTIWKWKTEYWDRRPSSRVREGEEQVQHSQNQLKEETNTVANEAKDEERLEHNRGSLFRVDPWKKINLLSDYQSRPIRVLIVGVHGFFPTKIIRPFIGEPTGTSTKFVTEAEEIVKEYFDQHKVPIEISKIALEREGEIFDRVDFFYEVMKHWSKEINNSDFIYFVSHSQGCPVTIMLLAKLIKNGIINLDNSQFFNDEIQFCSSKKIISVLAMAGINNGPFYGADQTLFVRAYQTIEKDSLRELFEFQKFDSKQSQSFIEGLRTIISNNVKITFVGSINDQLVPLYSSTCLFANHPNIFRAIFIDRGSQTPAFITRIVKIAGSLLNLGYNDHGIIKEISGSLAGTLTGGGHSTIYNEKQVYHLGIKFALETTDLSEMYPIEYSPYKLSELGANPYRLPWCMRGLMYESNKHFSNEEIKMLFKEFEEWEPETKQLKDIKNRLNGLKYRL
What are the official names of this protein?
Uncharacterized protein YML020W.
Protein: H2A1C_HUMAN
Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A type 1-C, H2A-clustered histone 6, Histone H2A/l.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RUVC_CHESB
Sequence: MTGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEILHLHMPQEAAVEATFVNKDAVATLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGHGEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQSPAWRLALEAQP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RIBB_VIBPA
Sequence: MNQSSLLAEFGDPITRVENALIALKEGRGVLLLDDEDRENEGDIIYSVEHLTNEQMALMIRECSGIVCLCLTDAQADKLELPPMVVNNNSANQTAFTVSIEAKVGVTTGVSAADRVTTIKTAANPHAKPEDLARPGHVFPLRARPGGVMTRRGHTEGTIDLMQMAGLQPAGVLCEVTNPDGTMAKAPEIVAFGHLHNMPVLTIEDMVAYRNQFDLKLA
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: RL23_METFK
Sequence: MSALSTQERLLQVILAPQITEKATRVADKYQQIAFRVRTDATKPEIKAAVELVFKVEVDSVTVVNVGGKVKRAGRTFGRRKDWKKAYVSLKPGQEINFAAGE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MRAY_RUEPO
Sequence: MLYWLTALSDGGDVWNLFRYITFRAGGAFMTALIFGFLFGRPLINVLRRKQGKGQPIRDDGPEGHFSKAGTPTMGGLLIVGALLTSTLLWARWDNPFVWMVLFVTLAYALIGFADDYAKVSKQNTKGVSGKMRLALGVIIAVIAALWASYNHPAELQNQLALPVFKDTLINLGLLYVPFAICVIVGSANAVNLTDGLDGLAIMPAMIAASTLGVIAYAVGRVDFTEYLDVHYVPGTGEILIFTAALFGAGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAVATKHELVLAIVGGLFVVEALSVIIQVLYFKRTGKRVFLMAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EI2BA_MACFA
Sequence: MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYAVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: SSUD_VARPS
Sequence: MQIFWFLPTHGDSRYLGTSEGARPIDLAYLQQIAGAADQLGYEGVLIPTGRSCEDPWVIASSLIGATKNLKFLVAVRPGLHQPSLAARMAATFDRLSGGRLLVNLVTGGDQSELEGDGVYLDHAQRYEQSAEFIRIWREILARSHSGQAFDYEGRHLSVKGAKLLYPPVQEPYPPVWFGGSSAAAHELAAEQVDAYLTWGEPPAEVARKIADVRNRAARKGRTVEFGIRLHVIVRETEDAAWKAAEELISRVDDETVIRAQAAFARMDSEGQRRMAALHAGGARRSRAELEISPNLWAGVGLVRGGAGTALVGDPKTVAARIEEYAALGLDKFILSGYPHLEEAYRFAELVFPLLSRKAQSRLAGGSLSGPFGEVVANLDAPSRLASQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: PRPE_BACC4
Sequence: MKYDIIGDIHGCFQEFQNLTEKLGYNWSSGLPVHPDQRKLAFVGDITDRGPHSLRMIEIVWELVIHKKEAYYAPGNHCNKLYRFFLGRNVTVAHGLETTVAEYEALPSHKQNIIKEKFITLYEQSPLYHILDEKRVIVCHAGIRQDYIGRRDKKVQTFVLYGDITGEKHADGSPVRRDWAQEYKGQAWIVYGHTPVAEPRFINQTVNIDTGAVFGGKLTGLRYPEMETISVPSSLPFVAEKFRPIS
What is the function of this protein?
Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical], Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the PrpE family.
Protein: MSX2_GORGO
Sequence: MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS
What is the function of this protein?
Acts as a transcriptional regulator in bone development.  Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation.  Probable morphogenetic role.  May play a role in limb-pattern formation.  In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE).  Binds to the homeodomain-response element of the ALPL promoter (By similarity).
What are the official names of this protein?
Homeobox protein MSX-2.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAX_I57A3
Sequence: MEEFVRQCFNPMIVELAEKAMKEYGEDRKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPKEAKKQLKKDLKSQGQCAGSPTKVSRRTSPALRILEPMWMDSNPTATLRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: ADH_DROSU
Sequence: MSLTNKNVVFVAGLGGIGLDTSRELVKRDLKNLVILDRIDNAAAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAQIKTIDVLINGAGILDDHQIERTIAVNYSGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGSKAAVVNFTSSLAKLAPITGVTAYTVNPGITKTTLVHKFNSWLDVEPRVAEKLLEHPTQTSQQCAENFVKAIELNKNGAIWKLDLGTLESITWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PYRD_MYCBP
Sequence: MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AB34G_ARATH
Sequence: MLGRDEDLVRTMSGRGSLGSTSHRSLAGAASKSFRDVFAPPTDDVFGRSDRREEDDVELRWAALERLPTYDRLRKGMLPQTMVNGKIGLEDVDVTNLAPKEKKHLMEMILKFVEEDNEKFLRRLRERTDRVGIEVPKIEVRYENLSVEGDVRSASRALPTLFNVTLNTIESILGLFHLLPSKKRKIEILKDISGIIKPSRMTLLLGPPSSGKTTLLQALAGKLDDTLQMSGRITYCGHEFREFVPQKTCAYISQHDLHFGEMTVRESLDFSGRCLGVGTRYQLLTELSRREREAGIKPDPEIDAFMKSIAISGQETSLVTDYVLKLLGLDICADTLVGDVMRRGISGGQRKRLTTGEMLVGPATALFMDEISTGLDSSTTFQICKFMRQLVHIADVTMVISLLQPAPETFELFDDIILLSEGQIVYQGSRDNVLEFFEYMGFKCPERKGIADFLQEVTSKKDQEQYWNRREHPYSYVSVHDFSSGFNSFHAGQQLASEFRVPYDKAKTHPAALVTQKYGISNKDLFKACFDREWLLMKRNSFVYVFKTVQITIMSLIAMTVYFRTEMHVGTVQDGQKFYGALFFSLINLMFNGMAELAFTVMRLPVFFKQRDFLFYPPWAFALPGFLLKIPLSLIESVIWIALTYYTIGFAPSAARFFRQLLAYFCVNQMALSLFRFLGALGRTEVIANSGGTLALLVVFVLGGFIISKDDIPSWLTWCYYTSPMMYGQTALVINEFLDERWGSPNNDTRINAKTVGEVLLKSRGFFTEPYWFWICIGALLGFTVLFNFCYIIALMYLNPLGNSKATTVVEEGKDKHKGSHSGTGGSVVELTSTSSHGPKKGMVLPFQPLSLAFNNVNYYVDMPAEMKAQGVEGDRLQLLRDVGGAFRPGVLTALVGVSGAGKTTLMDVLAGRKTGGYVEGSINISGYPKNQATFARVSGYCEQNDIHSPHVTVYESLIYSAWLRLSADIDTKTREMFVEEVMELVELKPLRNSIVGLPGVDGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLMKRGGQVIYAGTLGHHSQKLVEYFEAIEGVPKIKDGYNPATWMLDVTTPSMESQMSVDFAQIFVNSSVNRRNQELIKELSTPPPGSNDLYFRTKYAQPFSTQTKACFWKMYWSNWRYPQYNAIRFLMTVVIGVLFGLLFWQTGTKIEKEQDLNNFFGAMYAAVLFLGATNAATVQPAVAIERTVFYREKAAGMYSAIPYAISQVAVEIMYNTIQTGVYTLILYSMIGYDWTVVKFFWFYYYMLTCFVYFTLYGMMLVALTPNYQIAGICLSFFLSFWNLFSGFLIPRPQIPIWWRWYYWASPVAWTLYGIITSQVGDRDSIVHITGVGDMSLKTLLKNGFGFDYDFLPVVAVVHIAWILIFLFAFAYGIKFLNFQRR
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 34, ABC transporter ABCG.34, AtABCG34, Pleiotropic drug resistance protein 6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: 3S1B_LATLA
Sequence: MKTLLLTLVVVTIVCLDLGYTRRCFNHPSSQPQTNKSCPPGENSCYNKQWRDHRGTITERGCGCPQVKSGIKLTCCQSDDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin B.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPO10_METTP
Sequence: MIPVRCFSCGKVISSVWEEYRERIKSEPPGKVMDDLGIERYCCRRMLLSHVEVVEMLRRYQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_STAAE
Sequence: MKVIFTQDVKGKGKKGEVKEVPVGYANNFLLKKNYAVEATPGNLKQLELQKKRAKQERQQEIEDAKALKETLSNIEVEVSAKTGEGGKLFGSVSTKQIAEALKAQHDIKIDKRKMDLPNGIHSLGYTNVPVKLDKEVEGTIRVHTVEQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RNZ_PROM2
Sequence: MNVTFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGLSGNSKGIEIYGPSELRSYINSALKSSFCKLSYPLHFVEVENYASKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAQSLKIAPGPIYSELQQGKKVVLADGRTFDGKEFCGPPRVGESFVYCTDTVFSQSAVSLSKNANLLVHESTFSEEDENMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNTQLAKDFLTTEIK
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: VE1_HPV03
Sequence: MDDTSGTEGECSELERAGGWFMVEAIVDRRTGDTVSSDEDEEEDGGEDLVDFIDDRPVGDGQEVAQELLLQQAAADDDVEVQTVKRKFAPSPYFSPVCVHPSIENELSPRLDAIKLGRQTSKAKRRLFELPDSGYGQTQVDTESGPKQVQDICKTSQQDGCQGADEGRGRNVGGNGSQEEERAGGDGEESQTESVQTDTTACGVLAILKASNHKATLLGKFKEQFGLGFNELIRHFKSNKTVCSDWVVCVFGVYCTLAESFKTLIQPQCEYAHIQVLSCQWGMTVLTLVRFKRAKNRETVAKGFSTLLNVPENHMLIEPPKLRSAPAALYWFKTSLSNCSEVFGETPEWIVRQTVVGHALEEAQFSLSEMVQYAYDHDITDESTLAYEYALQADTDANAAAFLASNCQAKYVKDACTMCRHYKRGEQARMNMSEWIKFRGDKIQGDGDWKPIVQYLRYQDVEFIPFLCALKSFLQGIPKKSCIVFYGPADTGKSYFCMSLLKFLGGVVISYANSSSHFWLQPLAEAKIGLLDDATSQCWCYIDTYLRNALDGNQVCIDRKHRALLQLKCPPLLITTNINPLGDERWKYLRSRLQVFTFNNKFPLTTQGEPLYTLNDQNWKSFFQRLWARLNLTDPEDEEDNGNTSEPFRCVPGQNTRTV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: TRPV1_CANLF
Sequence: MKNWGSSDSGGSEDPPQEDSCLDPLDGDPNSRPVPAKPHIFPTAKSRSRLFGKCDSEEASMDCSYEEGQLASCPAITVSPVVMIPKHEDGPTCARQPSQDSVTAGSEKSLKLYDRRKIFEAVAQNNCEELQSLLLFLQKSKKHLMDSEFKDPETGKTCLLKAMLNLHDGQNDTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEGLTNKKGLTPLALAARSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFIYCLYMIIFTTAAYYRPVDGLPPYKLKHTVGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSLKTLFVDSYSEMLFFVQSLFMLGTVVLYFCHHKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSVPTESTLHRWRGPGCRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGIKRTLSFSLRSGRVSGRNWKNFSLVPLLRDASTRERHPAQPEEVHLRHFAGSLKPEDAEIFKDPVGLGEK
What is the function of this protein?
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli.  Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons.  Involved in mediation of inflammatory pain and hyperalgesia.  Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.  Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state.  Mild extracellular acidic pH (6. 5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.  Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin.  Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects.  Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
What are the official names of this protein?
Transient receptor potential cation channel subfamily V member 1, TrpV1, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Protein: RL3_PHOLL
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEIEDNRVTQVKELDNDGYRAIQVTTGSKKASRVNKPEAGHFAKAGVEAGRILREFRLSEGEEYAVGQSISVEIFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDASHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQLGNERVTVQSLDVVRVDAERNLLLVKGAVPGSTGGNLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: YD510_YEAST
Sequence: MLYNMNYLVFSLLWYFLVGGGKGEVCWRFLGIVKSPNT
What are the official names of this protein?
Putative uncharacterized protein YDR510C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MTB_CHAAC
Sequence: MDPCECTKSGTCNCGGSCTCTNCSCTSCKKSCCPCCPSGCTKCASGCVCKGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: DNLJ_PARPJ
Sequence: MARTSASHPATSAPAERAAWLRAELERANYAYYVLDQPDLPDAEYDKLFKELESIETEHPDLIVPDSPTQRVGGEAASGFEPVVHDQPMLSLNNGFADEDIVAFDKRVGDALGKNASEPPVPVDYAAELKFDGLAISLRYVDGAFVQASTRGDGTTGENVTENVRTIRSIPLKLKGKRVPHVLDVRGEVLMFKRDFERLNERQRAAEQKEFANPRNAAAGSLRQLDSKITAQRPLSFFAYGIGVLEGMEMPATHSELLDWYKELGLPVNSERAVVQGAEGLLGFFHGVGEKREKLPYDIDGVVYKVNRRDEQDALGFVSRAPRFALAHKFPAQEALTKLVAIDVQVGRTGAITPVARLEPVFVGGATVTNATLHNEDEVRRKDIRIGDTVIVRRAGDVIPEVVSALLDRRPSDAREFVMPTQCPVCGSSIERLPDEAIARCTGGLFCPAQRKQALWHFAQRRALDIDGLGEKIIDQLVEQNLVRTPADLFNIGFATLAELDRFAEKSAQNLLDSLEKAKHTTLARFIYALGIRHVGESTAKDLAKHFGSLDPIMDASVEALLEVNDVGPVVAESIHQFFAEEHNRTVIEQLRAPGKVTWPEGPPAPKAPQGVLAGKTVVLTGTLPSLAREEAKEMLEAAGAKVAGSVSKKTDYLVAGADAGSKLAKAEELGVPVLDEDGMRKLLEGQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.