PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_ALBFT
Sequence: MNHIRNFSIIAHIDHGKSTLADRLIQRCGGLQEREMEAQVLDSMDIEKERGITIKAQTASLKYKAQNGQIYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTALDLGVEVVPVLNKMDLPNADPDNAKIEIEDVIGIDATDAIACSAKTGMGIDEILEAVVARMPPPRGNPAGALRAMIVDSWFDTYVGVVMLVRVVDGRLAKGERIKMMATGTTYNADSLGVFTPANEPRESLEAGEVGYIIAGIRELQAAKVGDTITLIKAGTGGAAFTATEPLPGFKEIQPQVFAGLYPTEASEYESLRDSLEKLKLNDSSLRYQPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDQDLITTAPSVEYQVVQADGTVKMVENPSKMPDQGRLDEVREPIVTVHLYMPQDYVGAVMTLANQKRGVQMNMAYHGRQVMLTYEMPLAEIVMDFFDKLKSVSRGYASMDYEFKEYRAADVVKVDILLNGDKVDALSIIVHRSQSQYRGRAVVSKMREIISRQMYDVAIQAAIGSNVIARETIKAMRKNVIAKCYGGDISRKHKLLDKQKEGKKRMKQIGSVSVPQEAFLAILQVDA
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FTSH_CAUVN
Sequence: MNFRNLAIWLVIVAVLGGVFVVSQNSRTKSSSEISYSQLLKDVDAGKIKSAEIAGQTVLAKTADNKTLTVNAPMNSEELVNRMVAKNADVKFKSGSISFLAILVQLLPILLVVGVWLFLMRQMQGGAKGAMGFGKSKARLLTENKNRITFEDVAGVDEAKEELQEVVDFLKDPAKFQRLGGKIPKGALLVGPPGTGKTLIARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGIILIAATNRPDVLDPALLRPGRFDRQVVVPNPDVAGREKIIRVHMKNVPLAADVDVKTLARGTPGFSGADLANLVNEAALMAARKNRRMVTMQDFEQAKDKVMMGAERRSMAMNEEEKKLTAYHEGGHAIVALNVPLADPVHKATIVPRGRALGMVMQLPEGDRYSMKYQQMTSRLAIMMGGRVAEEIIFGKENITSGASSDIKAATDLARNMVTRWGYSDILGTVAYGDNQDEVFLGHSVARTQNVSEETARLIDSEVKRLVQYGLDEARRILTDKIDDLHTLGKALLEYETLSGEEIADILKGIPPKREEEEAATAVIAPSLVPLSPGAGASVTA
What is the function of this protein?
Absence of FtsH leads to increased sigma-32 levels, which suggests, in analogy to E. coli, that sigma-32 is a substrate for FtsH.  May play a role in the general stress response, as overexpression leads to improved resistance to salt stress.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: VATL_HELVI
Sequence: MAENPIYGPFFGVMGAASAIIFSALGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIAGSLDAPSNNYTLYKGFIHLGAGLAVGFSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVAIYLYTKQ
What is the function of this protein?
Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase 16 kDa proteolipid subunit c, V-ATPase 16 kDa proteolipid subunit c, Vacuolar proton pump 16 kDa proteolipid subunit c.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BTUB_ECO24
Sequence: MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGVSGSADLSQFPIALVQRVEYIRGPRSAVYGSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQAQTDNDGFLSKTLYGALEHNFTDAWSGFVRGYGYDNRTNYDAYYSPGSPLLDTRKLYSQSWDAGLRYNGELIKSQLITSYSHSKDYNYDPHFGRYDSSATLDEMKQYTVQWANNVIVGHGSIGAGVDWQKQTTTPGTGYVENGYDQRNTGIYLTGLQQVGDFTFEGAARNDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQLYGFYGNPNLDPEKSKQWEGAFEGLTAGVNWRISGYRNDVSDLIDYDDHTLKYYNEGKARIKGVEATANFDTGPLTHTVSYDYVDARNAITDTPLLRRAKQQVKYQLDWQLYDFDWGITYQYLGTRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: FRIH_SALSA
Sequence: MTSQVRQNFHQDCEAAINRQINLELYASYVYLSMAYYFDRDDQALHNFAKFFKNQSHEEREHAEKLMKVQNQRGGRIFLQDVKKPEKDEWGSGVEALESSLQLEKSVNQSLLDLHKVCSEHNDPHMCDFIETHYLDEQVKSIKELGDWVTNLRRMGAPQNGMAEYLFDKHTLGKEST
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
What are the official names of this protein?
Ferritin, heavy subunit, Ferritin H.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: AGN6_PAEDI
Sequence: MGSIDTPPHLPYRLDGKVALVTGAGRGIGAAMAVELARCGAKVIVNYARSSSFANAVVDEIKSLGSDAVAIQADVSQVSQTVRLFEEAVQVFGGLDIVCSNAGVVSFGHLSEVTEEEFDRVFSVNTRGQFFVAREAYRHLNSPGRIILMSSNTADSFTVPKHSLYSASKGAINTFVRCLAKDCGDKKITVNAVAPGGTVTDMFHETAKDYLPNADKMSKEQILQIVANVSPLTRCGYPIDIAKVVCFLASSESEWVNGKVLGVDGGAA
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites (PubMed:30746079).  The pathway begins with the assembly and cyclization of atrochrysone thioester by the non-reducing polyketide synthase Agnpks1 (PubMed:30746079).  The atrochrysone carboxyl ACP thioesterase AgnL7 then breaks the thioester bond and releases the atrochrysone carboxylic acid as the first enzyme-free intermediate (PubMed:30746079).  The decarboxylase AgnL1 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase AgnL2 (PubMed:30746079).  Emodin then undergoes reduction catalyzed by the oxidoreductase AgnL4 to yield the dihydroquinone tautomer which is the substrate for reduction by the short chain dehydrogenase AgnL6 reduction to produce hydroxyketone, followed by AgnL8 dehydration and likely spontaneous autoxidation to chrysophanol (PubMed:30746079).  Baeyer-Villiger oxidation by the oxidase AgnL3 leads to monodictyphenone via cleavage of the C-10/C-10a bond of chrysophanol (PubMed:30746079).  Alternative cleavage at the C-4a/C-10 bond of chrysophanol leads also to the formation some cephalone F (PubMed:30746079).  Further conversion to agnestins A and B, requires reduction to dihydro-monodictyphenone, oxidation to agnestin C probably via an epoxide, and rearrangement to either agnestin A or agnestin B directly, although agnestin A or agnestin B can also interconvert (PubMed:30746079).  Within the cluster, AgnR1 is the only unassigned oxidoreductase present which could be involved in this conversion.  However, AgnR1 seems not to be involved in this step, and thus genes involved in the proposed oxidation/reduction may be located elsewhere on the genome (PubMed:30746079).  Further agnestin A derivatives are probably formed by spontaneous decarboxylations, dehydrations and methanolysis reactions (PubMed:30746079).
What are the official names of this protein?
Short chain dehydrogenase AgnL6, Agnestins biosynthesis cluster protein L6.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PGK_FRACC
Sequence: MRTIDDLQVAGHRVLVRSDLNVPLDRSGDTPRITDDGRVRASVPTISALLDRGARVVVSSHLGRPKGEPDPKYSLEPVAGRLAELLGRPVAFAGDGSGDIAGAHAREVVAGLGDGEVALLENLRFAAGETSKDAAIRAAFADELSALAEFYVGDAFGAVHRAHASVADVPKRLPHAAGRLVLTELEVLRRLSSDPARPYSVVLGGSKVSDKLGVIRALLPKVDALLVGGGMCFTFLAALGHGVGGSLLETEMIETCKELLAEGGERIVLPTDVVVADRFAADADTAVVAADAIPAGWLGLDIGPASTELFAARLAGAATVFWNGPMGVFELAPFAAGTRGVAEAVAAGKGFSVVGGGDSAAAVRTLGIPEDAFSHISTGGGASLEYLEGKTLPGLAALDV
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6C_VITVI
Sequence: MDLPGPIHDFLLVFLGSGLILGGLGVVLLTNPIYSAFSLGLVFVCISLFYIPSNSHFVAAAQLLIYVGAINVLIIFAVMFMNGSEYYKDFNLWTVGDGVTSVVCTSIFASLITTILDTSWYGIIWTTRSNQIIEQDLISNSQQIGIHLSTDFFLPFELISIILLVALIGAIAVARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PUR9_PERMH
Sequence: MGRKALISVSDKTGVVEFAKELEKLGFQIISSSGTARVLKENGIDVTEVSDITGFPEIMGGRVKTLHPKIHGGLLAVRDNPEYMKQLEEQGIEPIDIVAINLYPFEQTVRKGADLDEIIENIDIGGPAMVRASAKNHKFVTIIVDPEDYGSVISELKEKGETSLETRRKLALKAFRHTAFYDSVISSVLNEKFGIDEKFPEEFSVPFRKKDTLRYGENPHQEAAVYISPVEYKGLSVAESEVLHGKEMSYNNFLDVEAAVNLVKEFDETACVIVKHNNPCGVAISHTPEKAYREALSRDPKSAFGGIVAFNRSVDIDTAKALTEIFLEVIVAPDFDKDAFDYLTEKKKNLRLVKIKNFDKKAEGPDYRRISGGILVQDRDTQLYNELKVVTDREPTDKEMEDLLFAWKVVKHVKSNSVVIAKNKATVGIGPGQTSRVDSLETAVKKAEEFNLDTEGSVLASEAFFPFRDSVDQAAKYGIKAIIQPGGSIRDNEVIQAANEHGIAMVFTGMRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RL11_BURPS
Sequence: MAKKIVGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAYADKSFTFVMKTPPATVLIKKAAKVDKGSSKPHTDKVGKITRAQAEEIAKTKMPDLTAADLDAAVRTIAGSARSMGITVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GLYA_NEIM0
Sequence: MFSKSVTLAQYDPDLAAAIAQEDQRQQDHVELIASENYVSCAVMDAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKKLFGAQYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTHGASVNISGKLYNAVTYGLDENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFREIADKVGAYLFVDMAHYAGLVAGGEYPNPVPFCDFVTTTTHKTLRGPRGGVILCRDNTHEKALNSSIFPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAAMAEELVKRGLRIVSGRTESHVFLVDLQPMKITGKAAEAALGKAHITVNKNAIPNDPEKPFVTSGIRIGSAAMTTRGFNEADVRVLANLVADVLSNPEDEANLAKVREQVTALCNKYPVYGA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_RHOPT
Sequence: MIRATAVRGQHRWTATPADTVVLDFDDRHRRRMAMTGTRGLSFLLDLEQAVALRGGDALVLEDGRLVEVVAAPEPLLEIRGHDPQHLVRLAWHLGNRHLPTQLMAKALRIRRDHVIADMVRGLGGKVVEIEAPFDPEGGAYAPAHDSGEAAHGHHDHAHHDHGHHGHAHHDHGHDHDHAHDHAHGHGCGHDHHGHDHHVHDESCGHQHSHGHSHKHEH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHJ_CITSI
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWHSVAVILYIYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVDQPEEVCIKVFAPRSNPKIPSVFWVWKSANFQERESYDMLGILYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: HYPA_RHOPS
Sequence: MHEMALCESMIEIIEREARDQHFARVRAVWVEIGALSHVEPEAMRFCFSAVAHGGIAADARFEIVSVSGAAWCMSCSKTVPLAQRSAPCPDCGGYQLQVTAGDELRVKELEVD
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: H2B1_BOVIN
Sequence: MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YBP2_YEAST
Sequence: MYNEQVNSGKSIKEKERYLDALLKILKDNPVTLKEIGWDLPKGLLQFFSRKNINVNIHLVFSPLVSSVMECFNELAINGNPKECLLTACELVSTLHIVLTETGDSDEENEDLNDSNRNDASNITDELSVITPEIGHYMAKNTVEFIPNLKIYVLFEFMSLLLKRVDTLYPSKFLAMVTSAIIKYVTTNVQAMDDPHFILRIVYNFCTNYSPAQPSASLTDGISTNDLEKIHDDESALQKKLLANLSVFVISNCLKNHPGNIDKIYFKTLMHKKTDENEIDASVLQICHQYYEYVTSLDVHMKELLEKCLVESRSIYNSLLMNPAASTPEFKEEINQLVYEVSYAYQIKKLADEKNLELDQYGVVILSAIHYSKNGTHLLPQIDIQSAIYLYLRCTTASLFSEIYENKFLESSVRYWLWVSTTETSTEKIKCALQELPGHITTAFLQMLLMKTCNESNNDTKLTEITLLRRLLYLMPESTSFTFIFETLLHCPYITAKIAVLDILRDMMIRSPEAANRDETVGLIEQQNPGNTANSVPIMPTLPPRPYITINEDRMASIHSIALICFSAAKQKKRTQGDLLLVLTYMKFFVSLRNKWDLGLLTLINKEISESFQGEGEPELAFINISNNTLGEYIEEMNIRS
What is the function of this protein?
Involved in oxidative stress response and redox homeostasis.  Required for hydrogen peroxide-induced activation of YAP1.  Acts in a parallele pathway to YBP1.
What are the official names of this protein?
YAP1-binding protein 2, YBP1 homolog protein 1.
What is the protein family that this protein belongs to?
Belongs to the YBP1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROD1_ARATH
Sequence: MALRCFPIWVCPQTTHHRSPLMGLAEFDADKRRRFCLWECSSSASQRAVTAIEGEIPFSRELKKSSDELGLTQETQSLSFHRDLSMLPKPLTANSLYSSDGDDSKVRISFQGIPGAYSETAALKAFPNCETVPCEQFEAAFQAVELWLVDKAVLPIENSVGGSIHRNYDLLLRHRLHIVQEVHLPVNHCLLGVPGVKKEDIKCVLSHPQALDQCVNSLNNLGIQRISAKDTATAAQTVSSSGKIDVGAIASVRAANIYGLDILAENIQDDVNNVTRFLILAREPMIPRTDRPYKTSIVFSLEEGPGVLFKALAVFALRSINLSKIESRPQRRRPLRVVDGSNNGSAKYFDYLFYIDFEASMADTRAQHALGHLQEFASFIRILGCYPMDLVR
What is the function of this protein?
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine (PubMed:17726025).  Dehydratase that uses arogenate and prephenate as substrates (PubMed:17726025).  Utilzes more efficiently arogenate than prephenate (PubMed:17726025).
What are the official names of this protein?
Arogenate dehydratase/prephenate dehydratase 1, chloroplastic, AtADT1, AtPDT1.
Protein: CYSP2_LEIPI
Sequence: MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNPHAQFGITKFFDLSEAEFAARYLNGAAYFAAAKRHAAQHYRKARADLSAVPDAVDWREKGAVTPVKDQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDDMNDGCDGGLMLQAFDWLLQNTNGHLHTEDSYPYVSGNGYVPECSNSSEELVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLTACIGKQLNHGVLLVGYDMTGEVPYWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGTSTSSETPAPRPVMVEQVICFDKNCTQGCRKTLIKANECHKNGGGGASMIKCSPQKVTMCTYSNEFCVGGGLCFETPDGKCAPYFLGSIMNTCHYT
What is the function of this protein?
The cysteine proteinases have a potential role in host-parasite interaction and virulence.
What are the official names of this protein?
Cysteine proteinase 2, Amastigote cysteine proteinase A-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Note=Associated with megasome, a unique lysosomal organelle found in intracellular amastigotes of the L.mexicana complex.
Protein: RS8_PYRHO
Sequence: MTLLDPLANALSHITNSERVGKREIYIKPASKLIGEVLRVMQKYGYIGEFEFIDDGRAGVYRVQLLGRINKAGAIKPRFPVKATEYEKWEKRFLPAFEFGILIVSTSQGVMSHKEARDRGIGGRLIAYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PROB_BRUA2
Sequence: MLKKLKDYRRIVVKIGSALLVDRATGLKRKWLESLGQDIAALQHAGVEVLVVSSGAIALGRTVLGLPKKALKLEESQAAAAAGQIALAKAYADVLGGHGIKSGQILVTLSDTEERRRYLNARATIETLLKLKAVPIINENDTVATTEIRYGDNDRLAARVATMMGADLLILLSDIDGLYTAPPHKNPDAQFLPFVETITPQIEAMAGAAASELSRGGMKTKLDAGKIANAAGTAMIITSGTRFGPLSAIDRGERATLFEAAHAPVNAWKTWISGNLEPAGRLTVDAGAVKALKSGKSLLPAGVKEVDGDFERGDTVAVMNEDGREIARGLIAYDAADARKVAGHKSDEISAILGYDARAAMIHRNDLVVRAASDAKAA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_HAEIN
Sequence: MTTFTHINSQGEANMVDVSAKAETVREARAEAIVTMSKETLSMIVEGKHHKGDVFATARIAGIQAAKRTWELIPLCHPLLLSKVEVNLEPLLETNQVRIQSLCKLTGKTGVEMEALTAASVAALTIYDMCKAVQKDIVIEHVRLLEKSGGKSGHFIAEEK
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: PETD_NEPOL
Sequence: MSVTKKPDLTDPVLRAKLAKGMGHNYYGEPAWPNDLLYMFPVVILGTLSCITGLAVLDPAAIGEPANPFATPLEILPEWYFFPVFQLLRTVPNKLLGVLLMAAVPAGLLTVPFIESINKFQNPFRRPVATTVFLIGTVVAIWLGIGATLPIDISLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TMM98_XENLA
Sequence: METVVIVAIGVLATIFLASFAALVVVCRQRYCRTKNLLTNYNNKPTVDLIGAMETQSEPSDLELDDVVITNPHIEAILEDEDWIEDASGLVSHCIAILKICHTLTEKLVAMTMGSGAKMKSPSSLSDIIIVAKRISPRVDDVVRSMYPPLDPKLLDARTTALLLSVSHLVLVTKNACHLTGGMDWIDQSLSAAEDHLAVLREAALATEPERPMTGADNFLQEQSAI
What are the official names of this protein?
Transmembrane protein 98.
What is the protein family that this protein belongs to?
Belongs to the TMEM98 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Secreted. Secreted, extracellular exosome. Note=Secreted by exosomes through a non-classical pathway.
Protein: RL5_RHIWR
Sequence: MADAYTPRFRKLYDETIVKAMTEKFGYKNHMEVPKITKIVLNMGVGEATQDKKKVEQAALEMTKIAGQKAVITKAKKSIAQFKLREGMPIGAKVTLRRERMYEFLDRFVTIALPRVRDFRGLNPKSFDGRGNYATGLKEQLIFPEISYDSVDKIRGMDVIVATTAKTDDEARELLRLFGFPFPADNEDQKQAA
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MED4_MOUSE
Sequence: MAASSSGEKEKERMGGVSGMAGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.