PharMolix/UniProtQA huggingface dataset:
Protein: ARP3A_XENLA
Sequence: MAARLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRLMKGVDDLDFHIGDEAIDKPTYATKWPIRHGIVEDWDLMERFMEQIIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKEKFSYVCPDLVKEFSKYDTDGAKWIKQYMGVNAVSKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDVKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911).  Seems to contact the pointed end of the daughter actin filament (By similarity).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Actin-related protein 3-A.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: URE3_STRT2
Sequence: MQLTMREQEKMMISLAAMIAQRRKDKGIKLNHPEAVALITDYVLEGAREGKTVAQLMDEARNLLTREDVMEGIAEMIPMIQVEATFTDSTKLVTVHDPIQ
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPR1_MUSPA
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAAVFKLETDRTVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISIIPIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFELKWDESKGLLPNDPQGPEFCHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTRRAFPHLVNAGKYSTTFFTVTFAALYSTHKEQNHPDYKVFFYLWVFFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITVTTFKPHVGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQEDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT
What is the function of this protein?
Plays a role in phosphate homeostasis.  Mediates phosphate export from the cell.  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (By similarity).  Potential receptor for xenotropic and polytropic murine leukemia retroviruses.
What are the official names of this protein?
Xenotropic and polytropic retrovirus receptor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VATF1_DROPS
Sequence: MALHSAIKGKLISVIGDEDTCVGFLLGGVGEINKNRHPNFMVVDKNTPVSELEDCFKRFLKRDDIDIILINQNCAELIRHVIDAHTSPVPAVLEIPSKDHPYDASKDSILRRARGMFNPEDLVR
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit F 1, V-ATPase subunit F 1, V-ATPase 14 kDa subunit, Vacuolar proton pump subunit F 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
Protein: ERPA_SHEAM
Sequence: MTEQTDVAMPISFTDAAAAKVKALLDEEQNDALKLRVYVTGGGCSGFQYGFTFDEKVNDGDFTVEKQGVQLVVDPMSLQYLMGGEVDYTSGLEGSRFFVKNPNATTTCGCGASFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: MTXH_METBF
Sequence: MFKFQKEQEIVNIAGVKIGGQPGELPTVLAGTIFYDKHEIVKDVARGLFDRDAAEKLINLQESSAEETGNPYIIHIFGTTPESITRYIDFVAEISEAPFLIDSPEGTVRSHAAEYVSEIGLADKAIYNSINMSINASEIEALALSDIDSSIILGFNAMDSSLQGRMEMLENGAGLLEEGLLSIADRCGIVNKLIDPSITPMGNGAGVALKMTITAKAKWGHPTGSGIHNAPSAWNWLNKKKEKDPVLYKICDVGSTCLQQAAAGDFILYGPIEYAPYIFPMAAMSDIMISEAVADLGIEPASRHPLNLLV
What are the official names of this protein?
Putative methyltransferase mtx subunit H.
What is the protein family that this protein belongs to?
Belongs to the MtrH family.
Protein: GCH1_AERHH
Sequence: MTSLSREALLVRAALEAEGLETPLVANALDGQQKREKIEGHMRAIMETLGLDLADDSLAETPHRIAKMYVNEIFSGLDYATFPKVTVIENKMKVDEMIMVRDISLTSTCEHHFVTIDGLAHVAYIPRGKVIGLSKINRIVQFFARRPQVQERLTQQILLALQTLLGTKDVAISIKATHFCVKARGVMDSTSYTTTTSLGGVFKTQPDTRAEFLAGLKR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RIR2_MYCLE
Sequence: MLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEVEYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit beta, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: AROQ_POLAQ
Sequence: MSKKASILVIQGPNLNLLGTREPDVYGKTTLEDIHQKLGELAKAQSVDLSTFQSNHEGELIDRIQKAKQDGVDFIIINPGAFTHTSVALRDVLAGVAIPFTEVHLSNIHQREEFRKHSYLSDIANGVICGLGAIGYELALQAAIARLQR
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RSLBB_DANRE
Sequence: MRLIQNMSTIAEYPSADCPSSRVIKIAVIGGSGVGKTALVVRFLTKRFIGDYERNVGNLYSREVQIDGEQVAIQVQDTPGVQVNANGLSCTDHVSRSIQWADAVVMVYSVTDRKSFDLIGQLHQLVTRTHSDRSIPIILVANKADLLHVRRVDAQEGPVLSSALSCSFYEVSASEDYNQVHSAFHRLCVDLAKLQPQTPINATSSVTEKKRSPLIPRPKSPNMQDLKRRFKQVLSAKVRTVTSV
What are the official names of this protein?
Ras-like protein family member 11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
Protein: THEM5_HUMAN
Sequence: MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSSGWIKLPSFKSNRDHIRGLKLPSGLAVSSDKGDCRIFTRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGGSLAAMMDETFSKTAFLAGEGLFTLSLNIRFKNLIPVDSLVVMDVELDKIEDQKLYMSCIAHSRDQQTVYAKSSGVFLQLQLEEESPQ
What is the function of this protein?
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271).  Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271).  Required for normal mitochondrial function (PubMed:22586271).
What are the official names of this protein?
Acyl-coenzyme A thioesterase THEM5, Acyl-CoA thioesterase THEM5, Acyl-coenzyme A thioesterase 15, Thioesterase superfamily member 5.
What is the protein family that this protein belongs to?
Belongs to the THEM4/THEM5 thioesterase family.
Protein: SYA_CLONN
Sequence: MEKMGLNQVREAYLKFFESKGHLRLPSFSVVPKNDKSLLLINAGMAPLKPYFTGLQTPPRKRVTTCQKCIRTGDIENVGKTSRHATFFEMMGNFSFGDYFKNEVIPWAWEFTTEVLKLPKEKLYVTIYLDDDEAYDIWTSKTDVDPKHIFRLGKEDNFWEHGVGPCGPCSEIHFYKDNGEIKSAEEFIEKSDADRAVEFWNLVFTQFDKDEDGNYNRLEFPNIDTGMGLERMATIMQGVETIFEVDTIKSILDKVAALANTKYGEDELKDVSLRIITDHVRSVSVMISDEVLPSNEGRGYVLRRLLRRAARHGKLLGIKGTFLYKIVDSVIENSGEAYPELKEKKDYIKKVISIEEERFAETIDSGMEILKEYIEDLEKNNKKVLSGEKVFKLYDTYGFPLELTEEILEEKGITVDMDSFNKEMKEQRERARAARSESTYMGTDVKILDTIPSEIETTFDGYENLELQSKVKVIIKDDAFADCINKGEKGIIVTDRTPFYAEMGGQIGDKGTISADGFMAKVQDCKNNIGGKIVHFVEVTEGSIKLEDEVLLEVDRKRRENIGKNHSATHLLHAALRKVVGEHVHQSGSYVDEDKLRFDFTHFESLTHEELKKVEDLVNDTIESVWDVVTKEMTIEEAKNSGAMALFDEKYGDKVRVVKMGDFSTELCGGTHISNVGKIGLFKIVSESGIAAGTRRIEAVTGHKALEFIEHKSDLLRQIASMLKCSEKDIINRLNQQNAELKDKDKEISALKSKLASGSEDDILKNIKEVKGVKLAVAALKDVDGEALRNLGDKIKNKIESGVVVLGSEVEGKVQFIAMASKDVVSKGVHCGTIVREIAKIAGGGGGGRPDMAQAGGRLPEKLNDAINEVENIMENLVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTX49_ARATH
Sequence: MAAPLLMIIKNQTDHRQDPNPNPTHLSSSIQEAKSIAKISLPLILTGLLLYSRSMISMLFLGRLNDLSALSGGSLALGFANITGYSLLSGLSIGMEPICVQAFGAKRFKLLGLALQRTTLLLLLCSLPISILWLNIKKILLFFGQDEEISNQAEIFILFSLPDLILQSFLHPIRIYLRSQSITLPLTYSAFFAVLLHIPINYLLVSSLGLGLKGVALGAIWTNVNLLGFLIIYIVFSGVYQKTWGGFSMDCFKGWRSLMKLAIPSCVSVCLEWWWYEIMILLCGLLLNPQATVASMGILIQTTALIYIFPSSLSISVSTRVGNELGANQPDKARIAARTGLSLSLGLGLLAMFFALMVRNCWARLFTDEEEIVKLTSMVLPIIGLCELGNCPQTTLCGVLRGSARPKLGANINLCCFYFVGMPVAVWLSFFSGFDFKGLWLGLFAAQGSCLISMLVVLARTDWEVEVHRAKELMTRSCDGDEDDGNTPFLLDSLDIEENLVF
What are the official names of this protein?
Protein DETOXIFICATION 49, AtDTX49, Multidrug and toxic compound extrusion protein 49, MATE protein 49, Protein NOVEL ION CARRIER 1, Protein NIC1.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SFI2_SEGFL
Sequence: KECMADETVCYIHNHNNCCGSCLCLNGPYARPWEMLVGNCKCGPKE
What is the function of this protein?
Insecticidal toxin.  Causes flaccid paralysis followed by death when injected into Heliothis virescens larvae.  Does not induce any toxic effects when injected intravenously into adult mice at a dose of 1. 25 mg/kg body weight.
What are the official names of this protein?
Mu-segestritoxin-Sf1b, Mu-SGTX-Sf1b, F5.7, Toxin SFI2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 16 (SFI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL33_CYTH3
Sequence: MAKKGNRIQVILECTEHKATGLAGTSRHITTKNRKNTPERIELKKYNSVLKKYTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MCFS1_YEAST
Sequence: MFRSGYYPTVTPSHWGYNGTVKHVLGEKGTKSLAFRDSKRQIPLHEFVTKHVPTLKDGANFRLNSLLFTGYLQTLYLSAGDFSKKFQVFYGREIIKFSDGGVCTADWVMPEWEQTYSLNAEKASFNEKQFSNDEKATHPKGWPRLHPRTRYLSSEELEKCHSKGYSYPLVVVLHGLAGGSHEPLIRALSEDLSKVGDGKFQVVVLNARGCSRSKVTTRRIFTALHTGDVREFLNHQKALFPQRKIYAVGTSFGAAMLTNYLGEEGDNCPLNAAVALSNPWDFVHTWDKLAHDWWSNHIFSRTLTQFLTRTVKVNMNELQVPENFEVSHKPTVEKPVFYTYTRENLEKAEKFTDILEFDNLFTAPSMGLPDGLTYYRKASSINRLPNIKIPTLIINATDDPVTGENVIPYKQARENPCVLLCETDLGGHLAYLDNESNSWLTKQAAEFLGSFDELVL
What is the function of this protein?
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity).  MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.
What are the official names of this protein?
Medium-chain fatty acid ethyl ester synthase/esterase 1, Alcohol O-acetyltransferase, Ethyl ester biosynthesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Protein: RS15_BURP1
Sequence: MSVADIKKSEVVAQFARGANDTGSPEVQVALLTARITELTGHFKTHAKDHHSRRGLLRMVSRRRKLLDYLKGKDADRYRALIEKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RS10_PARL1
Sequence: MQRQKIRIRLKGFDHRVLDVSTREIVNTAKRTGAQVLGPIPLPTRLEKFTVLRGPHIDKKSREQFEIRTHKRVLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: K2C72_RAT
Sequence: MSRQLTLYPGAERLGFSGCSAVISGRFSGSHASVRAGVKGAAFGSRSLFCVGGGRRLALSSGGRSGGFTLGHGGASGGRPGGFVGTVFGSAGLGPTCPSVCPPGGIPQVVVNKSLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDQNNSRRSLEPVHESYISNLQKQLEILSGDRVRLDSELRNMREVVEDCKKRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSMTDDIKFFKVLFEGEIAQMQSHISDTSVILSMDNNRQLDLDSILAEVRAQYEEIAVKSKAETENMYQCKIQELQATAGQHGDDLKLTKSEITEINRLIQRIHSEIGNMKKQCSNLETAIADAEQRGDCALKDARAKLDQLEGVLQQSKEELARMLREHQELMNVKLALDMEIATYRKLLESEESRMAGEYPSSVSISVVSSTNAGPGGAGFSVGFGASSNYNYRPLALEVKTKGSCGSELKDPPAKTSASSCVSKKASR
What is the function of this protein?
Has a role in hair formation.  Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 72, Cytokeratin-72, CK-72, Keratin-72, K72, Type II inner root sheath-specific keratin-K6irs2, Type-II keratin Kb35.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: GATB_LACP7
Sequence: MKVYETVIGLEVHVELATKSKIFCGCTTQFGGEVNAHCCPICMGMPGTLPVLNKKVVEFAIAAGLAMNCDITKNCKFDRKNYFYPDLPKAYQVSQLYLPICRNGSIEIEVDGIKKSIGIHEIHMEEDAGKLVHDPWEDCTLVDYNRCGVPLIEIVSEPDMRSAEEVIAYLEKLKLILQYLGVSDCKMQEGSLRADINLSIREVGEPEFGTRTEMKNMNSFKAIARAIEGERKRQIELLEDGKKVIQETRRWDDNKDTSFAMRSKEDAQDYRYFPEPDLVPMEISEEWLTEIKGREPELRDAKMLRYVKEYEIPEYDAGIITGSKNLADIFEATVSLCNKPKEVSNWLMVETMRLLKESEQDAEELKLSPANFASLIELIDAGKINRTIAKEVFEQIFKANVDPNAYIEEHGLGMVSDDGVVRSTIENILKENVQSVSDYKNGKDKAFGFLVGQTMKAMRGKANPSVINEILRELLSKA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RHAD_SALCH
Sequence: MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDETDIAPFAANFHEKPRYIALSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVALY
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL1B_HORSE
Sequence: MAAVPDTSDMMTYCSGNENDLFFEEDGPKQMKGSFQDLDLSSMGDGGIQLQFSHHLYNKTFKHAMSIIVAVEKLKKIPVPCSQAFQDDDLRSLFSVIFEEEPIICDNWDEGYVCDAAMHSVNCRLRDIYHKSLVLSGACELQAVHLNGENTNQQVVFCMSFVQGEEETDKIPVALGLKEKNLYLSCGMKDGKPTLQLETVDPNTYPKRKMEKRFVFNKMEIKGNVEFESAMYPNWYISTSQAEKSPVFLGNTRGGRDITDFIMEITSA
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: GLD2B_XENLA
Sequence: MYPNSPSLGRIPLPLPCARQQQTSAYLSKVPVSVAPDLLSPEQFFQASLNIHKNANLPRLLMNGNVLTVPPLSSPPWSYLNHSPLISPGSPPSSFQNRKRRSDEGNSPYDVKRQRFQSPQEQTVNHQAVPLRGDIRCSYPGSPAFPLLQSPSPPVLKGHSSNSGDCWLYDHIDTTLPVAKDKLSKQILDLFQALQQQVCDLKKKDICRAELQREIQQIFPQSRLYLVGSSLNGFGIRSSDADLCLVLKEEPMNQNTEARHILSLLHKHFYTRLSYIERPQFIRAKVPIVKFRDKVSGAEFDLNVNNVVGIRNTFLLRTYAYLDKRVRPLVLVIKKWANHHGINDASRGTLSSYTIVLMVLHYLQTLPEPILPSLQKKYPECFDRTMQLHLVHQAPRNIPQFLSKNETPLGDLLLGFLKYFAVEFDWSKDIISLREAKALPRTDDYEWRNKYICVEEPFDGSNTARAVYEKQKFDLIRAEFLKAWVALRDNRDLYSLLPVKGIMKKMHSL
What is the function of this protein?
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail.  In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation.  Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'-UTR.  In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn.  During maturation parn is excluded from the ribonucleoprotein complex, allowing poly(A) elongation and activation of mRNAs.  May not play a role in replication-dependent histone mRNA degradation (By similarity).
What are the official names of this protein?
Poly(A) RNA polymerase GLD2-B, xGLD-2, PAP-associated domain-containing protein 4-B.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_OLEA2
Sequence: MRWSNFYIPTLKEAPADAEVVSHKLLIRAGMIRKLTSGIYIYLPLGLRSIEKAASIVRQEMNSAGAQELLMPMVQPADLWQESGRWDFYGKELLRISDRHGRDYCLGPTHEEVITDLVRGEVRSYRQLPLNLYQIQTKFRDEIRPRFGLMRGREFMMKDAYSFDRDAQGLDLSYRAMYEAYMKIFSRMGLKFRAVEADSGSIGGSFSHEFMVLAETGEDTIAFCHDCDYSANVERAEVVCTLDECDAPVAGVEEVHTPDRHTVEEVCEFMNVPAAALIKTLLYVADGEPVAALVRGDRELNEAKLKNLLRADTLELASPEQVREWTGAPVGFAGPVGLGVKRLFADNELRLATDWITGANKADTHLRHVSLKRDTRLSGYADLRMITDKDPCPRCSGTLELTRGIEVGHVFKLGTKYSEAMGCKFLDENGKEQVMLMGCYGIGVSRVVAACIEQNSDENGIVFPPPIAPFEVLLLNLDGKNDDVNARVDELYGAVQAAGCDVLMDDRNERPGVKFKDADLIGVPMQLVVGGKGLARGIVEAKDRRTGEKTELPVDGFAQAFAAWRRQVLQGWGL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOK7_MOUSE
Sequence: MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDKCERSKGLRERSSLTLEDICGLEPALPYEGLAHTLAIICLSQAVMLGFDSHEAMCAWDTRIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDILVLARDIPPTVMGQWKLSDLRRYGAVPNGFIFEGGTRCGYWAGVFFLSSAEGEQMSFLFDCIVRGISPTKGPFGLRPVLPDPSSGGPSASEERVAQEALEALQLEKRLSLLSHSGRPGSGGDDRSLSSSSSEASHSDISASSRLTAWPEQSSSSAGTSQEGPGLVAAQGPGEAMLGASRPPLKPLRPRQLQEVGRQSSSDSGIATGSHSSYSGSFSSYAGSNLDVWRAGEEFGSLLSLPPGASAPEPRLCACPPGAAEYQVPTSLRHHYDTPRSLRQAPRDPSPASQGSSDHGSATDLGGQAPTGCPSSWLGARRRGQATEGPGSDAALPSPSPGESWEAGSPHAGPPPAFFLSCSICGGLKVKPPP
What is the function of this protein?
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis.  Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes.  Induces autophosphorylation of MUSK.
What are the official names of this protein?
Protein Dok-7, Downstream of tyrosine kinase 7.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Synapse. Note=Accumulates at neuromuscular junctions.
Protein: REXO4_KLULA
Sequence: MVLSSNWLSLQKSTDSDSVNKNKGGKKTKSNSKKRTVSVKKDKQYVDKKKKNGTGSKIMDMVANMNREIAKVEQERTKNTHADGQMINSEDRFESVLKQKLNEDVAKKSLSRTNGVGKYVSMDCEFVGVGPDGKDSALARVSIVNYYGNVVLDLFVRPKEPVTDWRTWVSGIKPHHMANAVTQEDCQKQVSNVLKGRILVGHSVHHDLTALMLSHPRRMIRDTSRHMPFRQKYSEGKTPSLKKLTKEILQLDIQDGEHSSIEDARATMLLYKSDKLEFEKLHNKQFGPSKPTQE
What is the function of this protein?
Exoribonuclease involved in ribosome biosynthesis.  Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
RNA exonuclease 4.
What is the protein family that this protein belongs to?
Belongs to the REXO4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YNFA_ECOLU
Sequence: MIKTTLLFFATALCEIIGCFLPWLWLKRNASIWLLLPAGISLALFVWLLTLHPAASGRVYAAYGGVYVCTALMWLRVVDGVKLSLYDWTGALIALCGMLIIVAGWGRA
What are the official names of this protein?
UPF0060 membrane protein YnfA.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.