PharMolix/UniProtQA huggingface dataset:
Protein: RISB_DESOH
Sequence: MPKLMEAGLSAKGKTFALIASRFNDFITDRLVSGAVDALVRNGAADKDIHLVKVPGAFEIPLLAKKMAEKGEYDAIVCLGAVIRGSTPHFDYVCAEVSKGIAQVSLEFSVPVIFGIVTTDTIEQAIERAGTKAGNKGWNAAVSAVEMANLMEVVTRA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: BRIX_ARCFU
Sequence: MQVLTTSRKPGRKTRRFAKVLARFFNWKYVNRGKLSLEDLAGIAERFWIISEVKGNPAILNLYERGEKTLEVSFTLSNVNKIKMDDSPAVFKGKAPIDPLVFGAIPQTKAGLKLTRKVEFRKKVVVKGDEWLFFYDDEMLFKLRILKISRSSR
What is the function of this protein?
Probably involved in the biogenesis of the ribosome.
What are the official names of this protein?
Probable Brix domain-containing ribosomal biogenesis protein.
Protein: E4PD_SHIDS
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPIDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATMQ_ASPFL
Sequence: MYRLLERTLDRFTGLVEYQPTYPFAAPTWVYLVGAILIQQLATRWYRYYKSWVNVPVVGGHGIIGSWIAAFRWTARARSLVNEGYQKYGDFAFQVSTPTRWEVFICNDEMVREYRNFTDERFSANALFEAKYTVPGAAEGVHKVPVPIVAKALTWQRTRAATKTDPYFEEFVKELQHAFDAETKFENEDWNDLCCFATGTRIVAHLTAKSLVGYPLSRDTELIDLFAEYGNAVPTSGFFIAMFPQILKPFAAKFCSAPKISARLDRIVMDELRKREANPRSEPQVQDITDWITFWSRTYPGTYTDQDIARSVVSAVFGAIHTTTQVLVHCLTDLAIRPEYIHPLREEVETILNRDDQQWTKEGLESMEKLDSFVKECQRFNPLDAGSLARRATKDFTFSKGLHIPEGTFVFTPNSPVLFDEKHYPDAQQFDGYRFYRLGRVTGRPLEYKFIAANLKYLQFGDGRHICPGRFMAADEIRLLLAHILVNYDIRPKDDGERPPNWTFKKILFPDMKGMVQLKRRSINISQPN
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the ATM2 gene cluster that mediates the biosynthesis of aflatrem, a tremorgenic mycotoxin with acute neurotoxic effects (PubMed:19801473, PubMed:2867895).  Synthesis of geranylgeranyl diphosphate (GGPP) by AtmG (a GGPP synthase) precedes condensation of GGPP with indole 3-glycerol phosphate, followed by epoxidation and cyclization by AtmM (a FAD-dependent monooxygenase) and AtmC (a prenyltransferase) to produce paspaline (PubMed:19801473).  AtmB is also essential for paspaline production, but its exact role has not been identified yet (PubMed:19801473).  AtmP, a cytochrome P450 monooxygenase, subsequently converts paspaline to 13-desoxypaxilline via PC-M6 by removal of the C-30 methyl group and oxidation at C-10 (PubMed:19801473).  AtmQ, a cytochrome P450 monooxygenase, then catalyzes the oxidation of 13-desoxypaxilline, first at C-7 to produce paspalicine and then at C-13 to form paspalinine (PubMed:19801473).  Finally, AtmD prenylates paspalinine to form aflatrem (PubMed:19801473).
What are the official names of this protein?
Cytochrome P450 monooxygenase atmQ, Aflatrem synthesis protein Q.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DCYD_ECO45
Sequence: MPLHNLTRFPRLEFIGAPTPLEYLPRFSDYLGREIFIKRDDVTPMAMGGNKLRKLEFLAADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPNTQLEELATRVEAQGFRPYVIPVGGSNALGALGYVESALEIAQQCEGAVNISSVVVASGSAGTHAGLAVGLEHLMPESELIGVTVSRSVADQLPKVVNLQQAIAKELELTASAEILLWDDYFAPGYGVPNDEGMEAVKLLARLEGILLDPVYTGKAMAGLIDGISQKRFKDEGPILFIHTGGAPALFAYHPHV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: APGM_METKA
Sequence: MRVTGLERKILVIVGDGMADRAVPELDGKTPLQAADTPNMDRLAREGSVGLLDPIRPGVRPGSDTAHLTLLGYDPFEVYPGRGPLEALGAGVEVRPGDVAFRCNFATAEERNGELVVVDRRAGRINEDEGTPKLAETINEEVDLPVEFEFKEAVGHRAVLVLRGGDLSADVTDADPKRVGKPVKDVKPTSDDPAAARTAEIVNEFVRKAYEVLKDHPVNRERERQGKPPANVILPRGAGQLEEVEPFSDRYGMSGAVVAGASLIKGIGRMLGMDVPEDEAITGRKDTDLKRKAELALEALDDHDLVLVNFNAVDEAGHDGDARGKVEMIERMDRELVGTLLEGIDPEETVVCLTADHSTPVAVGDHTADPVPVAIWTADARRDPVEEYDEISAARGCLGRFSGLHLLNVLRDLADRIEKFGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: MED15_CANGA
Sequence: MSSKETIPMHQRSQNVAELLTVLMDINKINGGDSTTAEKMKVHAKSFEAALFEKSSSKEEYQKTMKSKIDAMRSTRDKRKRESVGSASMMANLGQDGTNNNNNNNNNNNNNLNMAASFMGGDMFGRNQSPAQNSNANTNLNTNVGPGVNGPNGNDGTANPQMFMNQQAQARQQAAARQLKNRQMGGSSAQQQQLTQQQQQLLNQMRVAPIPKELLQRIPNLPPGVTTWEQVTALAQQNRLSAQDMSIAKDIYKIHQQYLIKAKLQQQQQRQQQQRQQGNPDVNNNMAGSNNNNNNNLPMAQQQMQQRQQQQQQSQQQQNRNPNQRHNVLSQINQMFTADEQRALLQEAMEACKNFQKTHFGGQMSDANKQAFIKKFINSKALKKLEAMRMAQGGNNNANLNKGQADMLQRQQANMQMNQQQQRAAQNQRRGPVMNDAVSQGYNNQMNSAADSTMNNSNQPMNIGNNGVNMIPNQSQQQQQTNRPKEQTPQQPQQRIQSNRSVPMLNPTPEDVEVVRRISAEAAKTQLRLTDLTNSLTPQERDEIKKRLQKNQQLFAQVSSYAPQVYLFTKSESFLKEVLQLRIFIKEILEKCSKGIYVVKLDTVDKLVIKYQKYWESMKIQLLRRQQLLQQQQQQQQQGMDPNRAQNSQQQQQQNQANMQQARNRKPTKNQTTPAIAASVAMNMNDKGASMSPALQKAGSAVPNFAQQMSPNMTPGTIPPTNVLSPHSQSHIPMVSPTMAKAASAAALKNDTASSSRRGSTKPRGKSTAPVTGKKTSNAPTPQVVPATVPSTTNLSAAGTPNIRNKSATPLTAGLSPKSTIRSNSNTALASAKTPSPMTVSIPQPGNSSVFKKEEEYLSKLQLRKEEIRFRQKQRLDILSSSPVDLFLTTVADCLGINDEEIELINKIPETTADNINNTGKKKLTKAAQKLRDKEILNVSIQVGEKDKLIMSSKAPDKVMDYSISAMSLAAVFKNLSSTGSLNNIALSGSNATTSKDIGNIYSHTGGVKRKFDEVEISPNSNGSPSASIMSESKKIKIDSPEDMFVTHSSEAAKGTNNSSLMDSGKEGSCKSMAGSATEVNDTSIWDWNFWTSIE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 15, Mediator complex subunit 15, Transcription regulatory protein GAL11.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14_TROW8
Sequence: MSKLSKIVKNEKRKVIVARYAARRQELKRIIAAPGTAPERRDEAQAALQKLPRDASPVRVRSRDVVDGRPRGILSRFGVSRIRFREMAHRGELPGITKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ATPD_SHIDS
Sequence: MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENSQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CRP_ECO57
Sequence: MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
What is the function of this protein?
A global transcription regulator.  Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription.  It can act as an activator, repressor, coactivator or corepressor.  Induces a severe bend in DNA.  Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.  Plays a major role in carbon catabolite repression (CCR) (By similarity).
What are the official names of this protein?
cAMP-activated global transcriptional regulator CRP, Catabolite activator protein, CAP, Catabolite gene activator, cAMP receptor protein, CRP, cAMP regulatory protein.
Protein: DPOL1_SULOH
Sequence: MARQITLFDFTLKKEQNKDESRKEEIPHANINEERRKPKEWIKEAEEGKSYFLLQVDYDGKKSKAICKLYDKETKKIYILYDNTGHKPYFLTDIDPEKVNKIPKVVRDPSFDHLETVIKIDPYSGNKIKLTKIVVKDPLAVRRMRNSVPKAYEAHIKYFNNYIYDLGLIPGLPYVVKKGKLEQLRPELKGEEVDEIRKAFADSDEMTKEAVNDWIPIFESEVPDVKRVAIDIEVYTPIKGRIPDPEKAEFPIISISLAGNDGTKRVLVLLREDVNSQITKHDVIVETFKSERELIRRFFDIILDYPIILTFNGDDFDIPYIYYRALKLNFTPEEIPFDIINDEGKYLAGIHIDLYKFFFNRAIRNYAFEGKYNEYNLDAVATALLGMSKVKLDTLISFLDLDKLIEYNSRDAEITLKLTTFNNNLVWKLIILLARISKMGLEELTRTEVSTWIKNLYYWEHRRRNWLIPLKEEILTRSSQIKTAAIIKGKRYKGAVVIDPPAGVFFNVVVLDFASLYPSIIRNWNISYETVDVENCKNKEYVRDETGEVLHYICKDKPGITAVITGLLRDFRVKVYKKKAKSQNISEEQRSVYDVVQRAMKVFINATYGVFGAENFPLYAPAVAESVTAIGRYVITTTVNYCRSIGLQVLYGDTDSMFLWNPSKEKLEEIIKFVKGKFGLDLEVDKVYKFVAFSGLKKNYLGVYPDGKTDIKGMLAKKRNTPEFIKKEFNEVKQLVTTINSPDDIPKIRDQLEYKIKEIYEKLRHKGYNLDELAFRVMLSKPLESYTKNTPQHVKAALQLRSYGVMVLPRDIIMFVKVKSKDGVKPVQLAKLSEIDVDKYIDAVRSTFEQILKAFGLIGANLLQLLSILSLT
What are the official names of this protein?
DNA polymerase 1, DNA polymerase B1, DNA polymerase I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: NU3C_BARVE
Sequence: MFLLYEYDIFWAFLIISSAIPVLAFFISGVLSPIRKGPEKLSSYESGIEPIGDAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSAFIEAFIFVLILILGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: 3S14_LATLA
Sequence: MKTLLLTLVVVTIVCLDLGYTRRCFNQQSSEPQTNKSCPPGENSCYNKQWRDHRGTIIERGCGCPQVKSGIKLTCCQSDDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin VAN-29.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FABV_SACD2
Sequence: MIIKPKVRGFICTNAHPEGCAANVREQIDFVKSQGEIADGPKKVLVIGASTGYGLASRITAAFGCGAATLGVFFEKPGTERKTGSAGFYNSVGFHAEAEKAGLYAKSINGDAFSDEIKAKAIDVIKRDLGKVDLVVYSLASPRRTDPKTGELYSSVLKPIGQSYTAKNLNTDTLKIADMTIEAANEEEIANTVKVMGGEDWELWVEALKEADVLAENAKTVAYTYIGDKLTWPIYGKATIGRAKEDLDRAATAINQKLADLGGSANVAVLKALVTQSSSAIPIMPLYISILYKVMKEEGTHEGCIEQLYRLFTEGVYTDTPRLDDANRFRMDEKELAAELQAKVEAIWPNVTEENLFEETDYKGYNAEFLKLFGFGVDGIDYEKDVAPDVALDLE
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: PEPQ_ACTP7
Sequence: MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFPTAENCWLFLDGKNKPTVYFYAPNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNPTACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEFEIEAIYQAQFAALKGHQAAKQAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLIDAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWIAEMLYEYDFVRLTPEQIFEEGISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRQSPPEVYPSLRCTRDLAENMVLTMELGFYFIDMLLNPLQNSPLARHINWHKIAEFKPFGGIRTEDNIVMRSQGAENLTQKAEIELQLSDH
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: MUTS_STAAR
Sequence: MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNNGYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATLLNEITTINPNEVVINDNISDHLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDAVQYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIERDTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQDTLVQVNQLEPLDDLLDILEQSLVEEPPISVKDGGLFKVGFNMQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQTLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQHQAKIISELDCLQSFAEIAQKYNYTRPSFSENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHELTTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMVENEPEINQENSNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AZOR_STAA8
Sequence: MAKVLYITAHPFNELVSNSMAAGKAFIETYQQQHPDDEVKHIDLFETYIPVIDKDVLTGWGKMSNGETLTDDEQMKVSRLSDILEEFLSADKYVFVTPMWNLSFPPVVKAYIDAISIAGKTFKYSAEGPQGLLTDKKVLHIQSRGGYYTEGPAADFEMGDRYLRTIMTFLGVPSYETIIIEGHNAEPHKTEEIKATSINNAEKLATTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RS19_GEOSM
Sequence: MARSIKKGPFVDGHLEAKAQAEQAGSKKVIKTWSRRSTIIPEFIGLTFAVHNGKKFIPVFVTENMVGHKMGEFSPTRTFYGHAADKKSKLKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: G3PT_MACFA
Sequence: MSKRDIVLTNVTVVQLLRQPCPVTRPPPPPEPKVEIEPQPQPEPTPVREEIKPPPPPSPPPRPATPPPKMGPAPRELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRDVGSPYVVESTGVYLSIEAASNHISAGAQRVVISAPSPDAPTFVMGVNENNYNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSKKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAIKAAAKGPMAGILAYTEDEVVSTDFVGDSHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK
What is the function of this protein?
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon.  Required for sperm motility and male fertility (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, Spermatogenic glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_HAPGR
Sequence: MAYPVQLGFQDAASPIMEELLYFHDHTLMIMFLISSLVLYIISLMLTTELMHTNTMDAQEVETVWTILPAAILILIALPSLRILYMMDEITTPSLTLKTMGHQWYWSYEYTDYENLCFDSYMVPSSDLKPGELRLLEVDNRIVLPTELSIRMLISSEDVLHSWAVPSLGVKTDAIPGRLNQATLMASRPGIYYGQCSEICGANHSFMPIVLELVPLKHFEEWLLSML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CXB5_MOUSE
Sequence: MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQEKIGEGYLYPNPGKKRGGLWWTYVFSLSFKATIDIIFLYLFHAFYPRYTLPSMVKCHAEPCPNTVDCFIAKPSEKNIFIVFMVVTAVICILLNLVELIYLVIKRCSECAQLRRPPTAHAKNDPNWANSPSKEKDFLSCDLIFLGSDAHPPLLPDRPRAHVKKTIL
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction beta-5 protein, Connexin-31.1, Cx31.1.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Beta-type (group I) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: SECA_SALPB
Sequence: MLIKLLTKVFGSRNDRTLRRMRKAVSLINAMEPEMEKLSDDELKAKTNEFRARIEKGESVESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKKVNKIIPHLIRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPGNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTANGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHANEAGIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALEAPTEEQIAQIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSDTINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLELPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEMQRREEAERLAQMQQLSHQDDDAAVAADLAAQTGERKIGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: NHRF1_RABIT
Sequence: MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKVGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPDTDEQFRKLGVQIRGELLRAQAGPEQAGPPAAPGEQGPAGENEPREVEKSHPERRELRPRLCAMKKGPNGYGFNLHSDKSRPGQFIRAVDPDSPAEASGLREQDRIVEVNGVCVEGKQHGDVVTAIKAGGDEAKLLVVDKETDEFFKKCKVVPSSEHLNGPLPEPFTNGEIQKNNPETLAPAASESPRPALARSASSDTSEELASQDSPKKEDSTAPSSTSSSSDPILDFSISLAVAKERAHQKRSSRRAPQMDWSEKKELFSNL
What is the function of this protein?
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.  Necessary for recycling of internalized ADRB2.  Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3.  Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3.  Involved in sperm capacitation.  May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.  May enhance Wnt signaling.  May participate in HTR4 targeting to microvilli (By similarity).  Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1.
What are the subcellular locations of this protein?
Cytoplasm. Apical cell membrane. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Endomembrane system; Peripheral membrane protein. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T- cells. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with CFTR at the midpiece of sperm tail (By similarity).