PharMolix/UniProtQA huggingface dataset:
Protein: YP55_SCHPO
Sequence: MNNMSLKFPDIAINSSESSDDEDPSSKNEKKDGSIKVVKGLTDEKKVFEKAKNDFDEALAIIDDDDFEYTKSEDDKVRRKIDFFILPIMCITYGMQYLDKTAVSYAAVYGMKQEAHLSGYVYSWLSTIFYLGYMIAQYPAGYLLQKFPISYFMFIAAFLWSACVLLMAACSNRHGLLTLRFFSGVFEGCVNPAFVALTAMWYKREEQPVRVVSWYAFNGVAIMVGALLGYGTGHIKGSLQNWKYPFLVIGAISTAWSFVYLFFPQNPVLARFLNAREKRIAVERVRKNRTGMETKKFKPSQALEAFKDPQVILIVLYNGLCQVTNAMSVFSALIIQGIGYSGINATLLTLPSGAFAVAGMIASGIFTHYFKKGRIPLAMTTSSLTIVGSIMIWKIPHSNPWPRVVGVWLFCTISSGNAVILSLLSSNISGYSKKVTVNATMFLFYSIGNIVSPQLFKAGQTPEYIEGIQASLVSVCLFEGVLALLAFYYIFENARRDKLLENNPALGGEIKNEEFLDKTDREQIKFRYVW
What are the official names of this protein?
Uncharacterized transporter C460.05.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Allantoate permease family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Protein: GLYA_CHLTR
Sequence: MASLLDRYLRNISDKSQQNLASVAYLASLDHLLHAFPSIGQSIVQELKSQRSRLKMIASENFSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECAETAKELFGAESAFVQPHSGADANLLAIMSIITQKIQSPAVQRLGYKTINDLPEQEYEALKAEMAQHKCLGPSLNSGGHLTHGTVRMNIMSKLMHCLPYEVNLDTELFDYDEIAKIAKEHKPTVLIAGYSSYSRRLNFATLKQIAEDCGAVLWVDMAHFAGLVAGGVFVGEENPMPYADIVTTTTHKTLRGPRGGLVLAKKEYANTLNKACPLMMGGPLPHVIAAKAIALKEAMTINFRKYAHKVVENARTLAEVFQRNGLRLLTGGTDNHMLIIDLTSLGVPGRIAEDMLTSVGIAVNRNTIPSDASGQWKTSGIRLGTPALTTLGMGSAEMEEVANIIVKVLRNITVRSNAESGSSKSEGELSEGIAQEARQRVADLLGRFPLYPEIDLETLV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_BRUAB
Sequence: MAKTSAVEKNKRREKLVKRHAVKRARLKAIVMDQGLPLEERFRATIRLAELPRNSAKVRIRNRCEVSGRPRGYYRKLKMSRIALRQLGSLGQIPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: TELT_HUMAN
Sequence: MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG
What is the function of this protein?
Muscle assembly regulating factor.  Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
What are the official names of this protein?
Telethonin, Titin cap protein.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere.
Protein: PDRP2_ARATH
Sequence: MNLHGVSGHHEPNSEPPIPTGSSSPKLKISPKLNRWSRGRALRSGVKLDRPIPRSDNSPRRQVTEAQPTDEADKKTTAIDVEVTAGKSIYLVSDGTGWTAEHSVNAALGQFEDFSLNRGSSVNTHLFSWVEDEERLIEIIKQAAKEGAMCFYTLANPSMAKSAKQACDQLGVLSVDILGPIIEGIASHLGVSPSGLTRGAPGRVKTLNDAYFKRIEAIEFTIKQDDGTLPENLSKADIVLVGVSRTGKTPLSTYIAQKGYKVANVPFVMGVEPPRTLFQVEPRKVFGLKIQLVVLQAIRRTRVKTLGVDTEAENNYSGIDLVRKELDFASRIYERNPGWAVIDVTNKAIEETAAVILRLYHDGRDTSTTVPRISKRY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation.  Has a much lower phosphotransferase activity than PDRP1 (PubMed:21883547).  Can use ADP as a high specificity substrate and GDP as a lower affinity substrate, but has no activity with UDP (PubMed:21414960).
What are the official names of this protein?
Pyruvate, phosphate dikinase regulatory protein 2, Pyruvate, Pi dikinase regulatory protein 2, AtRP2, PPDK RP2, PPDK regulatory protein 2.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_SULIL
Sequence: MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGIIPLHTKDAVKDADIIIFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIEPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDVSGTALRKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVDLVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSQVQNSLEEKIGNQLKDLIQKGKPKS
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GT6_ORYSI
Sequence: MAASETAPFGVSAASKGGGGVAGARAQHGQLAVAGRVHDALVFAAGAVAAVLVLLATASFLSPMPVTNLVAFRSLPVSVASTSAASAAIDADVGVRGGPGAAGRTFYDDSRVSYAVEVGRRGGITGWDARRAAWMRLRYPRGLNATAAGRERVVMVSGSQAPPCRGEGGDHLLLRFLKNKVDYCRLHGVELLYNNALLQPRMLAYWAKIPAVRAAMLAHPDAEWVWWVDADAVFTDMDFSLPLHKYKDHNLVVYGWNKEVYGERSWVGLNAGVFLIRNCQWSLDFMDSWARMGPASPEYARWGSVLHDTLRGKSDKESDDQSALVYLLSEHEEKWGAKTYLEKGYFFQGYWVEVVDRLDDIAARYEAAERRPSAAAAHLRRRHAEREHERYAAARNAAVRGAVPGPAGGGQSGWRRPFVTHFTGCQPCGGEPNKIYSKKSCADGMNRALNFADDQVLRNYGYRHKDPLSDEVRPLPFDYPAAR
What is the function of this protein?
Probable glycosyltransferase that may be involved in the biosynthesis of xyloglucan.
What are the official names of this protein?
Probable glycosyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 34 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: CAPSH_BPT6
Sequence: MTIKTKAELLNKWKPLLEGEGLPEIANSKQAIIAKIFENQEKDFQTAPEYKDEKIAQAFGSFLTEAEIGGDHGYNATNIAAGQTSGAVTQIGPAVMGMVRRAIPNLIAFDICGVQPMNSPTGQVFALRAVYGKDPIASGAKEAFHPMYGPDAMFSGQGAAKKFPALAASTQTVVGDIYTHFFQETGTVYLQASALVTIDASANDATKLDAEIKKQMEAGVLVEIAEGMATSIAELQEGFNGSTDNPWNEMGFRIDKQVIEAKSRQLKAAYSIELAQDLRAVHGMDADAELSGILATEIMLEINREVVDWINYSAQVGKSGMTLTPGSKAGVFDFQDPIDIRGARWAGESFKALLFQIDKEAVEIARQTGRGEGNFIIASRNVVNVLASVDTGISYAAQGLATGFNTDTTKSVFAGVLGGKYRVYIDQYAKQDYFTVGYKGPNEMDAGIYYAPYVALTPLRGSDPKNFQPVMGFKTRYGIGINPFAESAAQAPASRIQSGMPS
What is the function of this protein?
Major capsid protein that self-associates to form hexamers, building most of the capsid in association with pentons made of the capsid vertex protein and one dodecamer of the portal protein.  The major capsid protein self-associates to form 160 hexamers, building most of the T=13 laevo capsid.  Folding of major capsid protein requires the assistance of two chaperones, the host chaperone groL acting with the phage encoded gp23-specific chaperone, gp31.  The capsid also contains two nonessential outer capsid proteins, Hoc and Soc, which decorate the capsid surface.  Through binding to adjacent gp23 subunits, Soc reinforces the capsid structure.
What are the official names of this protein?
Major capsid protein, Gene product 23, Major head protein, gp23.
What is the protein family that this protein belongs to?
Belongs to the T4 phage capsid protein family.
What are the subcellular locations of this protein?
[Major capsid protein]: Virion. Note=Part of the capsid icosahedric shell of the immature virion. The capsid is made of 930 copies arranged as 160 hexamers. SUBCELLULAR LOCATION: [Mature major capsid protein]: Virion. Note=Part of the capsid icosahedric shell of the mature virion. The capsid is made of 930 copies arranged as 160 hexamers.
Protein: RIMP_MYCBT
Sequence: MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIADGDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRARGRKVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPPAPAELELAQSSEMGLARGTEAGA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_MARSD
Sequence: MNKYFLAGIISVVTLVLDQVTKIAVREKMVLWTSETVIPGFFNLVHVVNKGAAFGFLNRADITWQRNFFVVVTIIALGAIGMLLKSAEEKDKFQILGLGFVLGGAIGNLIDRILYHQVTDFLDFYYGSHHYPAFNVADIAICLGAFAMIVSFYKNK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSA_ECOBW
Sequence: MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKYTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGVHETLDELTTRLAEGLLEAAEEAGIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHMMLDEGVYLAPSAFEAGFMSVAHSMEDINNTIDAARRVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_LYSSC
Sequence: MKKQLVNMKGTKDGFVLRLDDQCAYSDLVEELKKKVLEGGIDGKVDVQLYLGYRYCTDEQIDELIHIVQETEQLIVASVQSEVLTVHESNQKMIESQQDTYLGVVRSGQILRSSGDIIIVGNVNPNGRVEAGGNVYVLGKLKGIVHAGVQGNKEAIIAASQFEATHIMIADQVEAMSDEHVKEINQAEMTCAFIGYDGRITYDQIHALKNIRPLLNVSKGGS
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: YOKG_BACSU
Sequence: MKYDNLLDATSQYGPQDLLLGRDGLISTGYWAKTQANILTGTGLPVSNDEMKTYLNLPKNVEIPQDFQKLYDVYNEYKKLCDWWLEKLLSCVNKMANDIYNVGSTTSELINEALQPGLRAITTASNDQDRQDAIQDFHEVCLILMRELDENQQSMKDVQNLLNSFLQGGNNFIGVTQLNNSFEEVMTYLDSQYNDESEIHDLLNIFMQFKKLLGESLEEHEINEKVKFSSELGPLIGYIVSEMLEYSDVQMFKQRIDNFQNLNGVDAQVALVVKVLSLFHGINIDLHNVIYQAERSLEFIEQTEGNWHSIANQFYSLAQGFENEDINKLSTDLDNAAATWEAVANKAKEFVTNSYQG
What are the official names of this protein?
SPbeta prophage-derived pesticidal crystal protein-like YokG.
What is the protein family that this protein belongs to?
Belongs to the cry6A endotoxin family.
Protein: DNLJ_STRS2
Sequence: MKTRISELVSVLNQYAKEYYQLDQPSVSDAEYDTLYRELVELETAHPELILPDSPTHRVGGKMLDGFEKYSHVYPLFSLQDAFSREELEAFDQRVRKEFPQATYICELKIDGLSISLTYEAGNLVVGATRGDGSVGENITENLKRVADVPLTLPEAVDITVRGECYMPKASFDRVNKQRQEAGEAEFVNPRNAAAGTLRQLDTGVVAQRGLATFLYQEASPSEATSQSQVLEKLDALGFVTNHEYCLAESIDDTWDFIEKIAERRDDLPYEIDGVVIKVNDLAIQEELGFTVKAPRWAVAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLSPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLKVVDKYRKEQEIMPIPSHCPSCQSDLQHYEDEVALRCINPICPSQLMSKLEHFASRDAMNIAGLGSSIVEKLFGAGLVHDVADIYKLTVDDLLTLEGFKEKSANKLYQAIQTSKSNSAECLLFGLGIRHVGSKASKILVEKFGDLETLAFADQEAIASLEGLGQVIAKSLTTFFASEGAQQLLAELKEAKVNLTYLGQVVDENAALSGMTVVLTGKLERMKRNEAKAKLEALGANVAGSVSKKTNLVVAGTDAGSKLTKAQELGIEIKDEAWLESL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: FMT_EHRCJ
Sequence: MKIIFMGSPEFSVSALSYLLENESHEVVAVYTKIPKPAGRRGRILTKTPVHIIAEQNNIEVNTPKSLKHDAEQEKILSLNPDVIVVVAYGLIIPQGVLSIPKYGCINIHPSLLPRWRGAAPIHYAILSGDDKTGVTIIQMNELLDEGDILLQRDIPIDEQDNIDTLSKKLAHLGSSMLIEVLDNIDNLVPIKQNNDDATYAHKIIDFHIDFNEAADVICRKVRALYPRAFLLFNGKRLRILKTSYYSDSSVQDLKPGAVIDSHMNIKCKDGVLVPLVVQMEGKNPCNIDDFILGYNVLNCSIA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: THII_SHEDO
Sequence: MKFIVKLYPEIMMKSKSVRSRFTKMLETNIRNVLKKVDEDAKVQRQWDRIMVRVPADRPELVDAFAERLGCIPGIAHVVQVNEYTFDSVDHIYQQVLPLYREQLAGKTFCVRVKRTGQHDFKSIEVERYVGGGLNQHTDAVGVKLKNPDLTINLEIDHEKLYMVVRRIEGLGGFPMATQEDVLSLISGGFDSGVSSFQFIKKGARTHYCFFNLGGSQHEIGVKQVAYHLWKTYGESHKVKFISVPFEGVVQEILERIDNGQMGVILKRVMMRAATLLADKYGIQALVTGESLGQVSSQTLTNLNVIDRCTDLLILRPLIAMDKQDIINQSRIIGTEDFAKSIPEYCGVISQKPTVKAVLSKIEAEELKFSENLIENIVAQAKVIDIKDIAIEMDNQIAAAEAETVVAVDTQEVVIDIRAQEEEEKNPLSLPGKTVMTIPFFKLSTQFADLDKSVTYLLYCERGVMSKLQALYLIEQGYTNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFD_SHESR
Sequence: MAFKIASSPHVTRNLHTSTVMQRVILCLLPGLVVQCAFFGWGTLIQVLLAIIVALSCEAAVMKLRNRSIKASLSDNSAMLTAILIGVAIPPLAPWWMIVMGTVFAIVIVKHLYGGLGHNLFNPAMAAYVLLLVSFPVQMTSWIAPSTVALNTPSVIDSLQLIFNVGAHGGMEQFRLGIDGISMATPLDTLKTDLSLGLTTTESMAKSIFDGGTGVGWFWVNLAYLAGGLVLLKLKAIRWHISTGVLAGLFVASSIGFLLSPDTQASPLFHLFSGATMLAAFFIATDPVTAATSPRGRLIFGALIGVLVYVIRTQGGYPDAFAFAVLLANLCAPFIDYYVRPRTYGHSAP
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GNAQ_PIG
Sequence: MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  Required for platelet activation.  Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity.  Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).  Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity).  Together with GNA11, required for heart development (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus. Nucleus membrane. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein: 092R_IIV3
Sequence: MKIDVVREMMAQRGFEEYKIRPEYMVGVNRETNDYIYIKIFPGKFELNTVREFLARQFYPIIDPDEKIVTKKTFKHIVQLVIISKTFQNSHFKEFREISRRIQLIRSDFFNINITTKAPRHERVPKDYIKNRFEIPIIKETDPNCIFYNFVKDDVIRVTRSDGDICYRLVK
What are the official names of this protein?
Uncharacterized protein 092R.
Protein: MATK_CYCTA
Sequence: MDKFRRNGKEDTFRQRRFLYPLLFQENLYAIAYDHYLSRSSSFESMENSSYNDRFSFLTVKRLISRIRQQNGSIVSFGNYNQNKNKLVGHNRNFYSELVLEGLTVVLEVTFSIQSKHYLEGMNEWNSFRSIHSIFPFMEDKFPHSNFLLDIRIPHSTHPEILVRTFRYWIQDAPSLHSLRSVLHEHRNLILSENLDQLILIASKEKTRLSLSVLWNYYVYECESLLVPLWKRFSYSRSLSYGAFLERTTFYRKIEHIVIFSHKSIKDLKKRIWFLKDPSIHYVKDRERFLIALRGTYLLVKKWRYHLTNFWQCHFHLRSQPYRMSIDELSKNCFSFLGYLFSVQMKTFVVKIKMLDDSFITDPITKEFDPIAPTTLLIGYLAKERFCDISGRPTGRLAWTGLTDDNILHRFDRIWRNILHYYSGSSKKDGLYRMKYILRLPCAKTLACKHKSAIRVVRERFGSELFTKSSPKERELISLSFSKTRSQRERIWHSDILQRNPFVNSWWNKQNLQVETPFDR
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MSBA_HAEIN
Sequence: MQEQKLQENDFSTLQTFKRLWPMIKPFKAGLIVSGVALVFNALADSGLIYLLKPLLDDGFGKANHSFLKMMAFVVVGMIILRGITNFISNYCLAWVSGKVVMTMRRRLFKHLMFMPVSFFDQNSTGRLLSRITYDSQMIASSSSGSLITIVREGAYIISLFAVMFYTSWELTIVLFIIGPIIAVLIRLVSKIFRRLSKNLQDSMGELTSATEQMLKGHKVVLSFGGQHVEEVHFNHVSNDMRRKSMKMVTANSISDPVVQVIASLALATVLYLATTPLIAEDNLSAGSFTVVFSSMLAMMRPLKSLTAVNAQFQSGMAACQTLFAILDLEPEKDDGAYKAEPAKGELEFKNVSFAYQGKDELALNNISFSVPAGKTVALVGRSGSGKSTIANLVTRFYDIEQGEILLDGVNIQDYRLSNLRENCAVVSQQVHLFNDTIANNIAYAAQDKYSREEIIAAAKAAYALEFIEKLPQVFDTVIGENGTSLSGGQRQRLAIARALLRNSPVLILDEATSALDTESERAIQSALEELKKDRTVVVIAHRLSTIENADEILVIDHGEIRERGNHKTLLEQNGAYKQLHSMQFTG
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RBFA_GEOSL
Sequence: MFNRSEKVAEAIHELVSGLIVKGMKDPRIGFITITGVKVTDDIRQATIYYTVMGDDEARVSTARGLASATGFLRREIGKQLRLKFAPELHFKYDQSIEYGNRIDQLLKEIETEKGSDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAS_ECO27
Sequence: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLVD_ASPFN
Sequence: MLDTISESRPNGLATLGVVVATFATYLALKALYNLYLHPLRKFPGPKLAAIGPYYEFYYDVMKDGMFLWEMERMHQVYGPIVRVNANEIHIRDPHYYSTVYAGNHRSTDKYHDAVAAFSVPQASLATIHHKVHRLRRSILNPYFSKAAVTRLESAINERIERMCSRLEETMHYGQVVDLDAGFAALTADIVTTYFYGQNFDYLGNEGFKFQVRDAILGLIQFYHFTRFFPWIANTIKKLPIPIMRLIHPGAAYLVSSQEEIKDSIRASLDKGNKADAKSVIVQALEDPTIPPQERTLDRLGDEGTTIIFAGTETTARALSVGMFHILNNKTILKKLREELDTLPGVSSGVYSHVQLECLPYLTGAVQESLRLSHGPAIRLPRVANDKALKYGDYIIPPGTPVSLCTVLVHQDPCIFPDPHRFDPERWVKASKEGVNLDKFIAAFTKGTRQCLGINLAYAEIYLTFAKLIRTFNMEIYDTTVDDLTVHHIRLTGAPKQGTGEVKVKVTEKIL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate (PubMed:31885262).  The tetracyclic core is synthesized by the terpene cyclase flvE and the cytochrome P450 monooxygenase flvD (PubMed:31885262).  The terpene cyclase flvE catalyzes the cyclization of farnesyl pyrophosphate (FPP) to form (1R,4R,5S)-(+)-acoradiene and the cytochrome P450 monooxygenase flvD is then responsible for oxidative conversion of (1R,4R,5S)-(+)-acoradiene into the tetracyclic cage present in the final product flavunoidine (PubMed:31885262).  In parallel, the N-methyltransferase flvH dimethylates L-lysine to give N,N-dimethyl-L-Lysin which is decarboxylated by flvG to afford dimethylcadaverine (PubMed:31885262).  The terpene cyclase-like protein flvF is the enzyme that attaches the dimethylcadaverine precusor at the C-7 of the tetracyclic cage to yield pre-flavunoidine (PubMed:31885262).  The cytochrome monooxygenase flvC hydroxylates the C-10 position of pre-flavunoidine whereas the NRPS flvI acylates the terpenoid core at the hydroxylated C-10 with dimethylpipecolate to yield final flavunoidine (PubMed:31885262).  The bifunctional enzyme flvA and the dehydrogenase flvB are responsible for the synthesis of the dimethylpipecolate precursor (PubMed:31885262).  The PLP-dependent lyase domain of flvA might use L-O-acetyl-homoserine and alpha-keto-isovalerate to form an intermediary ketone that can cyclize intramolecularly to yield an imine (PubMed:31885262).  The imine can be reduced by flvB to yield the 6-carboxylated pipecolate (PubMed:31885262).  The C-terminal alpha-KG-dependent oxygenase domain of flvA is then proposed to catalyze the decarboxylation to yield dimethylpipecolate (PubMed:31885262).
What are the official names of this protein?
Cytochrome P450 monooxygenase flvD, Flavunoidine biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.