PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_SALTI
Sequence: MTTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEFQAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMFADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGRADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKMMREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PR28_MYCTO
Sequence: MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR
What are the official names of this protein?
Proline-rich 28 kDa antigen.
What is the protein family that this protein belongs to?
To M.leprae ML0031.
Protein: PFF1_ASPCL
Sequence: MARQYSRTNPLGFTPWPVTIITALVYLALVIPLLVVQHVVPSAPGSDPAGLNLTEAWADLQVLTNGFHPYNSHRNDDVHKWLLQRVHEIIDSAPARSTDSAHPPAVFVFDDDQSNLTFSGRGNELGVYFESTNILVYIRGTEDDETQWWADPQGQPASKGGVLVNAHYDSVSTGYGATDDGMGVVSCLQLLRYFTTPGHAPRRGLVVLLNNGEEDFLNGARVYSQHPLSRLPHTFVNLEGAGAGGRASLFRSSDTEVTRPYARAPHPFGSVLSANGFEAGLISSQTDYVVLEGDLGLRGLDIAFIEPRARYHTDQDDARHTSVDSLWHMLSAAVATTEGLVDDASDQFDGAPREDGKVASGSGSKAVWFDLFGSTLAVFELHTLFALSVTLLIVAPLVLLATSIALVRADRMYLFRSTARVPGSDDFDEGVSLQGVRGFFRFPFLLVIPTGVAVGLAYLVTKINPYIIHSSEYAVWSMMISAWVFLAWFVSRVADFARPSAFHRVYVLTWMFVAEWVLLVIATVYENRYGLAGGYFVFFALSGTFLATWISYLELFALPRKSEYARQIAPPSRYASNHGSRLGTSSGEHGMDDAEDEEDDDGDDEDEARNVEEEPTESTSLLRGRGQRTTFANYVRVTGDYLHGAGDDEPRETHVYGREQAWSAGLPKWTWVLQFLLSAPIVLILVGPLALLLTAALRQTAQDGSSPLFVYIAIAVLTTLLVTPLLPFIHRYTHHIPLFLLLVFTGTLIYNLVAFPFSPSNRLKLFFLQEVDLDTGVNRAFLSGAHPFVYEVARSLPSAAGQNVSCDLSAARPKCSWYGIPPQVQATATPDTADWVSFNITRSADQPTRARFSVAGQNTRACRLVFDDPVRSFAVLDSAYDPRFPHLSPQGTQEIRLWSREWGHTWTVDVEWTVPAVDGESRGVSGRVVCLWSDGNAPGVIPALDEVRRYSPVWTAVSKLSDGLVEGSRRFEV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: UNG_NOCSJ
Sequence: MSALAGLVDKGLMAPDWAQALAPVDEQIAAMGRFLREELAAGRTYQPTGEWVFRAFQRPLADVRVLIVGQDPYPNPEHPIGLSFAVRGDVWPLPPSLVNIYTELRDDLGLMPPRHGDLTAWADQGVMLLNRSLTVRPGASNSHRGKGWEPITACAIEALVRRGGPLVAILWGSDARNLRPMLGQIPVVESPHPSPLSAYRGFFGSRPFSRANRLLVEQGGRAVDWALPME
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEK1_CAEEL
Sequence: MERKGRERKLPGMKIVMPTPVETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEILDTVWRR
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1 (PubMed:11751572).  May phosphorylate pmk-1 (PubMed:12142542, PubMed:16166371).  Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development.  Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:11751572, PubMed:12142542).  Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:22216003).  Involved in resistance to the nematotoxic C. cinerea galectin Cgl2 (PubMed:20062796).  Probably by promoting pmk-1-mediated activation of skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003).  Probably downstream of tir-1, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898, PubMed:22308034).  Regulates susceptibility of B. thuringiensis pore-forming toxin Cry5B and Cry21A (PubMed:15256590).  Involved in the response to oxidative stress (PubMed:15888317, PubMed:22308034).  May regulate transcription factor daf-16 localization during oxidative stress (PubMed:15888317).  By phosphorylating pmk-1, regulates skn-1 localization during oxidative stress (PubMed:16166371).  By phosphorylating and activating pmk-1, plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034).  Up-regulates expression of gcs-1 in intestine upon arsenite treatment (PubMed:16166371).  Regulates germline proliferation in response to osmotic stress, starvation and germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:16729024, PubMed:19497412).  In association with mek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024).  Plays a role downstream of tir-1/nsy-1 in regulating susceptibility to anoxia (PubMed:21212236).  In males, by regulating pqn-41 expression, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008).  Involved in egg laying (PubMed:12142542).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase sek-1, MAP kinase kinase sek-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: NSA2_PHANO
Sequence: MPQNEYIERWQKQHGKRFDHDERKRKRIAREGHDGSKKAQNYRGLRAKLYAEKRRKEKIQMKKTIRAHEERNVKTSEPAEPSTEALPQYLLDRSNEKNAKALSSAIKQKRNEKAARFSVPLPKVKGISEEEMFSVVKTGKKTAKKSWKRMITKPTFVGPGFTRRPVKYERFIRPMGLRYKKANVTHPELSVTVQLPIISVKKNPQNPLYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGRYAQITNNPENDGCLNAVLLV
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  May play a part in the quality control of pre-60S particles (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein NSA2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PUR5_COXBN
Sequence: MQSMPDSTRHPPLSYCKAGVDIEKAADLVEAIKPIAKRTRRPGVLSGIGGFGGLFELPRGYKQPVLVSGTDGVGTKLKLAVELNRHDTIGIDLVAMCVNDVITTGAEPLFFLDYYATGHLNNEQAKQILTGIGAGCELAEVALIGGETAEMPGLYRQKDYDLAGFCVGVVEKEKIIDGSRVRVGDALIGIASSGPHSNGYSLIRKILARAKIPLSQSFENKSLADGLLAPTRIYVKTIKRLFSEINVHALAHITGGGLIENVPRVLPSYTQAVIDSNGWEWPAIFHWLQKQGKVPIEEMWRTFNMGVGMVLCLDKKEIRKTLELLAALGETAWILGEIQSSSEEQPRVTITP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURR_ECODH
Sequence: MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALLDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: MSCL_HERA2
Sequence: MFKEFKEFAFKGNVLDLAIGVIIGAAFGKIVTALVDVVIMPIISIILSLILNDVNIATWQFSIGATPIMIGVLIKTIIEFLIIAFVLFLFVKGINSTRRKQEVEAPAAPPPSEEVLLLREIRDSLQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y523_PSEA7
Sequence: MLKKTLAALALGSALFTAGQAMAADYKIDKEGQHAFIEFRIKHLGYSWLYGRFNDFDGSFTFDEKNPSADKVKVTINTNSVDTNHAERDKHLRSGDFLNVGKNPTATFESTEVKANGDSADITGNLTLNGVTKPVTIKAKLLGQGNDPWGGYRAGFEGSATLKLKDFGIKMDLGPASQEVELLLSVEGIRQ
What are the official names of this protein?
UPF0312 protein PSPA7_0523.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSAL_PROMA
Sequence: MTEFQDPFLKSSEPVKFNEKYVDSSVRPGDIGIVDQWAVTPVSDPCVGNLSTPVNSGYFTKAFLNNLPFYRGGLSPNFRGLEVGAAFGYLLYGPYAMTGPLRNTDYALTAGLLGTIGAVHILTALLVLYNAPGKAPNIQPSDCTINNPPADLFTRSGWADFTSGFWLGGCGGAVFAWLLCGTLHLDTIMPIVRGVWAAG
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: HEMH_OPITP
Sequence: MPNRAVLLVNLGSPDSTSVPDVRRYLDEFLGDERVIDRPAQPFRSILVHRIIVPRRSPNSAHAYEQIWTKDGSPLIITSRNVQQKLAATLGPETPVYLAMRYGQPSIASVLGQIVADGVSELLLIPQYPHYAMSSWETVVVKVYEEAARQAPQLRVTTVQPFFDDADYIEALHAVSAPYFAQPHDYVLFSYHGIPVRHLCKADSSHAHCQIVNDCCNTPSPVHATCYRAQVFATTRALAARAGLAPDRHSVSFQSRLVGEPWLSPYTDHELERLAKAGIKRILVLCPAFLSDCLETLEEISVAGKETFVQAGGESFTQIPCLNDQPPFIDFLANRVRTWLQASHR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_YEAST
Sequence: MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
What is the function of this protein?
Plays an important role in nitrogen catabolite repression.  Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1.  Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation.  Is also an atypical glutaredoxin without a catalytical cysteine residue.  Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form.  Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) activities.
What are the official names of this protein?
Transcriptional regulator URE2, Disulfide reductase, Glutathione peroxidase.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEV_HUMAN
Sequence: MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPPGPFGAVAAASHLGGHYH
What is the function of this protein?
Functions as a transcriptional regulator.  According to PubMed:12761502, it functions as a transcriptional repressor.  Functions in the differentiation and the maintenance of the central serotonergic neurons.  May play a role in cell growth.
What are the official names of this protein?
Protein FEV, Fifth Ewing variant protein, PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, Pet-1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: APGM2_METJA
Sequence: MRAILILLDGLGDRASEILNNKTPLQFAKTPNLDRLAENGMCGLMTTYKEGIPLGTEVAHFLLWGYSLEEFPGRGVIEALGEDIEIEKNAIYLRASLGFVKKDEKGFLVIDRRTKDISREEIEKLVDSLPTCVDGYKFELFYSFDVHFILKIKERNGWISDKISDSDPFYKNRYVMKVKAIRELCKSEVEYSKAKDTARALNKYLLNVYKILQNHKINRKRRKLEKMPANFLLTKWASRYKRVESFKEKWGMNAVILAESSLFKGLAKFLGMDFIKIESFEEGIDLIPELDYDFIHLHTKETDEAAHTKNPLNKVKVIEKIDKLIGNLKLREDDLLIITADHSTPSVGNLIHSGESVPILFYGKNVRVDNVKEFNEISCSNGHLRIRGEELMHLILNYTDRALLYGLRSGDRLRYYIPKDDEIDLLEG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2, BPG-independent PGAM 2, Phosphoglyceromutase 2, aPGAM 2, aPGAM-Mj2.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: GCH1L_CLOAB
Sequence: MSLKVKDLCNIIEDFAPISLKEDFDNVGLMVGDREASVDAIMTALDCTMDVIDEAIEKNCNMIITHHPILFKKPSKITMDTLLGKKIIKIISNNINVYSAHTNLDSVKDGINDAVVNILGFDKSSILAKNNKAVKEAGIGRVVELEQNMTLKELCDRVKESFKIQSLRYCGDEDKKIHSFAVINGSGQDFFEEARKRGVDCIITGDTSYHYVSDYNEMNIAVIDAGHFGTEWPSVVVMSKKLEGALHKMGINTPILVSQNNIDPYKFK
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: NV_IHNVO
Sequence: MDHRDINTNMEALREVLRYKNKVAGHGFLFDDGDLVWREEDDATWRRLCDVVNALISSKRMQRVLYMDLSITKGEGHLLFVDLQGTKNRLHKEPRFRRHLILIEDFLAYPR
What is the function of this protein?
Plays an essential role for the viral pathogenicity.
What are the official names of this protein?
Non-virion protein.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus NV protein family.
Protein: DEOC_SHESW
Sequence: MTDLKKAAQRAIELMDLTTLNDDDTDQKVIDLCHKAKTPAGNTAAICIYPRFIPIARKTLDEIGAEDIQIATVTNFPHGNDDIAIAVLETRAAVAYGADEVDVVFPYRALMEGNETVGFELVKACKEACGEVLLKVIIESGVLADPALIRRASELSIDAGADFIKTSTGKVPVNATLEAAEIMLTVISEKNTQVGFKPAGGVRDAAQAAEFLGVAERILGADWVSPRTFRFGASSLLNSLLHTLELADAPKPTQGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLD15_BOVIN
Sequence: MLVAVEIFGFFLTAVGLLMLGVTLAHSSWRVSTVHGNVITTNTIFENLWYSCATDSMGVHNCWEFPSMLALSGYIQACRALMITAILLGFLGLFLGMVGLRCTNIGGLELSRKTKLAATAGALHILAGICGMVAVSWYAFNITRDFFNPLYAGTKYELGPALYLGWSACLLAILGGICLFSNCCCSRDRDPATGVQLPYKAPVIPAASLAARLPAAASDEEGDSSFGKYGKNAYV
What is the function of this protein?
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.  While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules.  Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability.  CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions.  Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis.  Required for normal Na(+)-dependent intestinal nutrient uptake (By similarity).
What are the official names of this protein?
Claudin-15.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
Protein: TCEA2_HUMAN
Sequence: MMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQSSDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC
What is the function of this protein?
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
What are the official names of this protein?
Transcription elongation factor A protein 2, Testis-specific S-II, Transcription elongation factor S-II protein 2, Transcription elongation factor TFIIS.l.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR8_CUSOB
Sequence: MSRDTIAEVLTVIRNANMDGKKTVKIPSSNITENIIKLLLREGFLENVRKHYENGNYFLVLTLRHQKTKKGTFTNILNLKKISRPGRRIYSTSKKIPRILGGIGIVILSTSHGILTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid.
Protein: ATPA_CHLAT
Sequence: MIKIQPEEISSVIRKQIEQYNQEVKVVNIGTVLQVGDGIARIYGLAKVMAGELLEFEDGTIGIALNLESNNVGAVMMGEGLTIQEGSSVKATGKIAQIPVGEAYVGRVVNALARPIDGKGEIPTSEYRLLESPAPGIISRRSVYEPLQTGLVAIDAMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQNVICVYVAIGQKASSVAQVVNTLEERGAMEYTIVVAENANAPATLQYLAPYTGATLAEYFMYKGRHTLVIYDDLSKQAQAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSTALGEGSMTALPVVETQAGDVSAYIPTNVISITDGQIFLSADLFNAGLRPAINVGISVSRVGSAAQVKAMKQVAGKLKLELAQFAELEAFSQFASDLDKATQNQLARGRRLRELLKQAQAAPLSVEEQVSTIYTGINGYLDSIEVEDVRKFLAGLRGFIAKSYPKVYEIVRTTKTFTTEAEDLLKEAINEYKKNFSATAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RLMN_ACIAC
Sequence: MTKNLLDFDLDGLAAFCEQLGEKRFRAVQLFRWIHQRGASDFARMSDLAKSLREKLSGCAHVAALPVISEHVSADGTVKWLFDVGDGNAVESVFIPEDDRGTLCISSQAGCAVGCRFCSTGHQGFSRNLTSGEIVAQLWFAEHALRARLGTQERVISNVVMMGMGEPLQNYTALVPALRTMLDDHGYGLSRRRLTVSTSGVVPMMDRLSQDCAVAMAVSLHAPNDALRDQLVPLNRKYPLRELLDACTRYLEHAPRDFITFEYCMLDGVNDQPEHARQLIDLVRPRGGEGVRCKFNLIPFNPFPASGLHRSNPQQVAAFAKMLSDAGIVTTVRKTRGDDIDAACGQLAGDVKDRTRAAERMARQRTIVLKPVA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMI1B_DANRE
Sequence: MHRTTRIKITELNPHLMCVLCGGYFIDATTIVECLHSFCKMCIVRYLETSKYCPICDVQVHKTKPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAEHPVDATNGSNEDRGEVSDEDKRIIADDEIISLSIEFFDQKKLDGKDGEEKESTKEVTVKRYLQCPAAMTVMHLRKFLRSKMDIPCTFQIEVMYEDEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPGCKKIKLSSPRNDMSGGRRPDTESDSSSDKPNSPSIVAAPSTSSSMPSPNTPVQSTHPSFPHISTINGVSAKVGHNGQTPFSSKVCKTSHNGSNSLG
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity).
What are the official names of this protein?
Polycomb complex protein BMI-1-B, Polycomb group RING finger protein 4-B.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPX_STAS1
Sequence: MAQITFKQEPITLLGSQVKTGETAPEFTLLDNDLNEVNLSTYDGQKKLISVVPSIDTGVCDQQTRKFNEEASQEDGVVLTVSVDLPFAQKRWCASNGLDNVITLSDHKDLSFGKNYGVVMEELRLLARSVFVLDKNNKVVYSEIVSEGTDFPDFESALEAYRNI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: LLDD_ECOL5
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.