PharMolix/UniProtQA huggingface dataset:
Protein: SYCY1_PANTR
Sequence: MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSFSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKIINPSCPGGLGVTVCWTYFTHTGMSDGGGVQDQAREKHVKEVISQLTRVHSASRPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTDTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYNYVVSKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEILTAQPLLRPNSAGSS
What is the function of this protein?
Endogenous envelope proteins may have kept, lost or modified their original function during evolution.  Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein.  The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity).
What are the official names of this protein?
Syncytin-1, ERV-W1 provirus ancestral Env polyprotein, ERVWE1 envelope protein, Endogenous retrovirus group W member 1, Envelope polyprotein, Syncytin.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
What are the subcellular locations of this protein?
[Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Syncytin-1]: Virion.
Protein: PYRB_BRUC2
Sequence: MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLAYQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: HASP_SCHPO
Sequence: MESRSKVKTYGKNRRYINKDIEIWASLDERPCALKPRNIENFNNQERSDLEHIHSKPKKDSLLSWNILLKKGSYKENELLAKRNQNLVPTVIIPASPRDNASKSVVSKKEVVNLSSSVALSGKPANNSKLDPLHRLLQIVAQEDALPFSQFVKSQTFEIQKIGEASYSEVYQASNADDVPVVWKVIPFGEDGQAQYADVLNEVQISQWIKVDGFANLHQVVVVKGTYPSLLLEEWDRYLMQNGSENDRPDSYSSTQLYCVLCLDHSGTDLEHFELRSWRECWSVFYETLKILSLVETRYEFEHRDLHWGNILIRKADRSEEEVSFLLNEISLDDIESVDFPGSQDKADDFDNILQVTLIDFTLARASYSQGIISYNEFNDPDLFNGVDDYQFDIYRLMSRVTKGRWAQFFPITNVLWLHYLIHQLLHKKNLSSPLTETETLMRSRLKQIFRLIDPVKTMQFQQAEDSIRSKSTVTSATSLLNWVRQKY
What is the function of this protein?
Serine/threonine haspin-like protein kinase involved in cell cycle regulation.  Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph).
What are the official names of this protein?
Serine/threonine-protein kinase haspin homolog hrk1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: CCND2_XENLA
Sequence: MELLCCEGDTVRRAQPDPALLLDDRVLHNLLTVEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQRCEEEVFPMAMNYLDRFLAVIPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPLPKDKLLLIRKHAQTFIALCATDFNFAMYPPSMIATGSVGAAICGLQLDVGETSLSGDSLTEHLAKITSTDVDCLKACQEQIESVLVSSLRQTRQQTQQRNSSKSVDELDQASTPTDVQDINL
What is the function of this protein?
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.  Hypophosphorylates RB1 in early G(1) phase.  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
What are the official names of this protein?
G1/S-specific cyclin-D2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Protein: RECA_MACCJ
Sequence: MSERQKALDTVIKNMEKSFGKGAVMKLGDRTDRNVSTVSSGSITLDSALGVGGYPKGRIIEIYGPESSGKTTVALHAIAEVQRQGGVAAFIDAEHALDPVYAKNLGVDIENLYLSQPDHGEQGLEIAEAFVRSGAVDIIVVDSVAALTPKAEIEGEMGDSHMGLQARLMSQALRKLSGSVSKSNTIAIFINQVREKIGVMFGNPETTPGGRALKFYSSVRLEVRRAEQLKQGQEIVGNRTKIKVVKNKVAPPFKVAEVDIMYGKGISREGEIVDLGAEYEVLQKSGAWYSYDGERIGQGRENIKTYLKENPEVRDEIDQKIRKAMGVGASLEEASAQKEEVPVEDKLFDDELE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRA10_GIBZE
Sequence: MSQIIDALVIGGGPAGLGAALGLCRQNHSVVLLDSVSYRNTIDTIPDNRMHMVATWDHRRPDEFRVAARKELQRYERFKYREVEVVSVRQTTSTQSGKLEALFNAKAADGTEYAARKLILATGVKDVFPKIEGFSECWAKGMYVLSPNSNELCIARETKYRSFHCLFCHGYEDRNSESVGVLAVGECAETSTVARMARAAHQFSRSITIYTNGNSELGDQVYRLLGKEGWCSINNLGIKKVYMPQKTPASPITVQVELSDGTTKTEDFLVHKPATVQASALYTQLGLQLTAEGDIKVKEPMFETSKAGVFAVGDCASPNKFVSSASTSGGFAAAGAAMQLQAGF
What is the function of this protein?
Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
Thioredoxin reductase FGSG_00043, Gramillins biosynthetic cluster protein FGSG_00043.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: DYL1_EMENI
Sequence: MASEKKDKLEPQIKSVDMSEDMQQEAVEVAIEAMEKYHIEKDIAQYIKREFDSRKGATWHCVVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).  Also a component of the nuclear pore complex (By similarity).
What are the official names of this protein?
Dynein light chain, cytoplasmic, 8 kDa cytoplasmic dynein light chain.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.
Protein: RLMN_POLAQ
Sequence: MTSPRVNLLDFDADQMAAYVAGLNEKPFRAKQLMQWIHQRGVSDINDMSDLAKSFRATLLDKVEVLSLPVIKDEHATDGTRKWLLDVGAGNAVESVFIPEDDRGTLCISSQAGCAVNCRFCSTGRQGFSRNLTSGEIIGQLWFAEHLLRNDPEAIRRIEKYPTPGWEHTGRVISNVVMMGMGEPLLNYDNVVSALRLMLDDRAYGLSRRRVTVSTSGVVPMIDRLAQDCPVALAVSLHAPNDALRDQLVPLNQKYPLRELLDACERYLPFAPRDFLTFEYCMLDGVNDSDIQAKELVRLLRNIKCKINLIPFNPFPESGLKRSSAQRVNAFAGILLDAGMVATVRKTRGDDIAAACGQLAGDVVDRTRVRERDIHSAEIEIAEVESDVQPNEQPIEWLKKLT
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_LACP3
Sequence: MRTTFLAKPGEIERKWYVVDATDIPLGRLSSVVASILRGKNKPQFTPNVDTGDNVIIINASKLKLTGKKASDKIYYHHSQHPGGLKHEIAGDLLRDNPARLVEYSVKKMLPTKNTLGHQQFLKLHVYAGEEHPHLAQKPEVLDISNLI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NQOR_SALHS
Sequence: MAKILVLYYSMYGHIETMAHAVAEGAKKVDGAEVIIKRVPETMPPEIFAKAGGKTQNAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLGSVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ARNT_SHIF8
Sequence: MKSVRYLIGIFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPDFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFAPLAMLLAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVISPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWSFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIVRQERLVLIQYRPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPIS_TRIL1
Sequence: MRTPLIAGNWKLFKTLADATALIDELVPLVSDVKDVEIVVAPVFTAINTVAKAAGKTGVKVAAQDCYWEDEGAFTGEVSPKLLKDAGCSHVIIGHSERRQYFGETDGTVNLKTKAAIRAGLTVLLCVGESLAQRESNDTFKVIETQVRGGLADIPAAELTQIVVAYEPVWAIGTGKTASDAQAQEVHAFIRTLVAQIYGPSEADAMRILYGGSVKPENIKGLMSQPDIDGALVGGASLKAESFAGIVRFKG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_BORT9
Sequence: MTKSIGCDIIKVTRFNSFLQNRKKLERFFTQREIENSAMKGKGVLESLAGKFSAKESLIKALSPLINIKIKYSLKDIEIISLPKGNIIFQLHNDIKTLINQMNLKLYLTISHEREYAIAFVIVEN
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSA_STAA8
Sequence: MKYLILSLVANLLVFGVLSAIGLNINILAAMMIVLVIPIMISGILFFKTNIDKTYIFFNIIFIDFYYYIYNVHLMTLPKFNNYIKAEMMELEDIDVLITSKDFGFDEILFYTLYLLLILIVLYYLKKQVKHKI
What is the function of this protein?
Accessory element involved in the expression of sarA and several virulence factors.  Modulates SarA production and/or function in a strain-dependent manner.  Affects the transcription of the accessory gene regulator (agr) and genes encoding virulence factors including alpha toxin (hla) and protein A (spa).
What are the official names of this protein?
Protein msa, Modulator of SarA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_XANOR
Sequence: MAVQKSRVTPSRRGQRRSHDALTAKQLSTDPTSGEIHLRHHITADGYYRGKKVITTKSSAVQED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL26_CAEEL
Sequence: MKVNPFVSSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITREKANGSTVHIGIHPSKVAITKLKLDKDRRALVERKAAGRSRVTGILKGKHTDETVN
What are the official names of this protein?
60S ribosomal protein L26.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: VG42_HAEIN
Sequence: MMANNSTSFFVNLAGNVSQQAARFSNSIANMANKNVSSLNKVSRAISAVSKGFNGLGNITIPIIGVGAAAGATMVGKSMLRTAADFEMAKIRMKQTFGEQGEAADAWLKKFATDTPMAFADTQDAMMRLKTAGIDPMNGSLQALVDYNAKVGGDKANLDGYISAISKGFIKGKLSMEEINPLLERNVKVFEILAKETGGKYTADQMQKMLQEGKLGRKAIHALLRGMGRDAQGAAKEQMKTWDGLVSNLEDTWTSMQARFMEHGAFDALKKELGDFVEWLNEKIDDGTLDDFPKTVSDTLIEALKNLKEMAKDVKPVLESIGSVMSWVSEKAGGYGNLAKFMGALYLGNKVLRNDKVQTLGGWGWSGAKWGYNKIFNRKKGGAGGLADGVAGALGATVGVTPVYVTNFPMGFGGGGGGGYGYDVIEDGRDKDKKTQKKNKPPRPKRGRGSVRSPVAAVAASAAAVPKVAAPVTTASSGVARSVGNGVKSLGRGASKAVPYLGTGLAVAEGVTVLMDDTTNTKEKSEAIGSIAGATAGAIVGQALIPIPVVGAAVGSYLGGWLGEWLGSEVGEYLSDPEPIKNELNGTINIAVKASDQLIATATQAKIQTNQQRDSLETAVQMGTLGMGGMW
What are the official names of this protein?
Mu-like prophage FluMu protein gp42.
What is the protein family that this protein belongs to?
To phage Mu protein gp42.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ABEC2_MOUSE
Sequence: MAQKEEAAEAAAPASQNGDDLENLEDPEKLKELIDLPPFEIVTGVRLPVNFFKFQFRNVEYSSGRNKTFLCYVVEVQSKGGQAQATQGYLEDEHAGAHAEEAFFNTILPAFDPALKYNVTWYVSSSPCAACADRILKTLSKTKNLRLLILVSRLFMWEEPEVQAALKKLKEAGCKLRIMKPQDFEYIWQNFVEQEEGESKAFEPWEDIQENFLYYEEKLADILK
What is the function of this protein?
Probable C to U editing enzyme whose physiological substrate is not yet known.  Does not display detectable apoB mRNA editing.  Has a low intrinsic cytidine deaminase activity.  May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
What are the official names of this protein?
C->U-editing enzyme APOBEC-2, mRNA(cytosine(6666)) deaminase 2.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: UBP37_CANLF
Sequence: MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLHAAMKPSQGSGSFGAILGSRTSQKETNRQLSYSDNQASSKRGSLETKDDIPFRKVLGNPGRGSIKTATGSGITVTRTIPSLTSASTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRTGSKDYSSGSTNLDRTNVSGQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVPGEENSPDISATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKNFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMSGCEQQQDDLEKDSKPCRIEPDKSELENSGFDGMSEEELLAAVLEMSKREASPTLSHEDDDKPTSSPDTGFAEDDIQEMPENQDPVETEKPKTVTEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAL
What is the function of this protein?
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry.  Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex.  Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro.  Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).  Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 37, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: PRA1H_ARATH
Sequence: MAFSPNPLSLSVPDPAFESWLRDSGYLELLDHRTSAAAAAASSSASVSSSAAATSAASDDVVSSITGGFFASLLSRLVTVSSLLTINPFSKLSADDFSGDTTPWTTGFIGNCDSYSFPSSSQQARMRVHENIKRFARNYATLFIVFFACALYQMPLALVGLLGSLALWELFKYCSDKWKFDRHPSMRKLSIGIGQCATAVLLTFLNVQMALFSALAISYSVMILHAGFRKLTPSKKPTRGR
What is the function of this protein?
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
What are the official names of this protein?
PRA1 family protein H, AtPRA1.H.
What is the protein family that this protein belongs to?
Belongs to the PRA1 family.
Protein: BGLI_ASPNC
Sequence: MARVDFWHTASIPRLNIPALRMSDGPNGVRGTRFFNGIPAACFPCATALGATWDAHLLHEVGQLMGDESIAKGSHIVLGPTINIQRSPLGGRGFESFAEDGVLSGILAGNYCKGLQEKGVAATLKHFVCNDQEHERLAVSSIVTMRALREIYLLPFQLAMRICPTACVMTAYNKVNGTHVSENKELITDILRKEWNWDGLVMSDWFGTYTTSDAINAGLDLEMPGKTRWRGSALAHAVSSNKVAEFVLDDRVRNILNLVNWVEPLGIPEHAPEKALNRPQDRDLLRRAAAESVVLMKNEDNILPLRKDKPILVIGPNAQIAAYCGGGSASLDPYYTVSPFEGVTAKATSEVQFSQGVYSHKELPLLGPLLKTQDGKPGFTFRVYNEPPSHKDRTLVDELHLLRSSGFLMDYINPKIHSFTFFVDMEGYFTPTESGVYDFGVTVVGTGRLLIDNETVVDNTKNQRQGTAFFGNATVEERGSKHLNAGQTYKVVLEFGSAPTSDLDTRGIVVFGPGGFRFGAARQVSQEELISNAVSQASQASQVIIFAGLTSEWETEGNDREHMDLPPGTDEMISRVLDANPDNTVVCLQSGTPVTMPWVHKAKALVHAWFGGNECGNGIADVLFGDVNPSAKLPVTFPVRLQDNPSYLNFRSERGRVLYGEDVYVGYRYYEKTNVKPLYPFGHGLSYTTFSRSDLKITTSPEKSTLTDGEPITATVQVKNTGTVAGAEIVQLWVLPPKTEVNRPVRELKGFTKVFLQPGEEKQVEIVVEKKLATSWWDEQRGKWASEKGTYGVSVTGTGEEELSGEFGVERTRYWVGL
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase I, Beta-D-glucoside glucohydrolase I, Cellobiase I, Gentiobiase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMA_CVBLS
Sequence: MFLLPRFVLVSCIIGSLGFDNPPTNVVSHLNGDWFLFGDSRSDCNHVVTTNPRNYSYMDLNPALCDSGKISSKAGNSIFRSFHFTDFYNYTGEGQQIIFYEGVNFTPYHAFKCTTSGSNDIWMQNKGLFYTQLYKNMAVYRSLTFVNVPYVYNGSAQSTALCKSGSLVLNNPAYIAREANFGDYYYKVEADFYLSGCDEYIVPLCIFNGKFLSNTKYYDDSQYYFNKDTGVIYGLNSTETITTGFDFNCHYLVLPSGNYLAISNELLLTVPTKAICLNKRKDFTPVQVVDSRWNNAMQSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYDSPCFSQQGVFRYDNVSSVWPLYPYGRCPTAADINTPDVPICVYDPLPIILLGILLGVAVIIIVVLLLYFMVDNGTRLHDA
What is the function of this protein?
Structural protein that makes short spikes at the surface of the virus.  Contains receptor binding and receptor-destroying activities.  Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells.  This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.  May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one.  May become a target for both the humoral and the cellular branches of the immune system.
What are the official names of this protein?
Hemagglutinin-esterase, HE protein, E3 glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.