PharMolix/UniProtQA huggingface dataset:
Protein: HS3S1_HUMAN
Sequence: MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:8900198, PubMed:9988768).  Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768).  This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768).
What are the official names of this protein?
Heparan sulfate glucosamine 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, 3-OST-1, Heparan sulfate 3-O-sulfotransferase 1, h3-OST-1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Golgi apparatus lumen.
Protein: ICAM1_GORGO
Sequence: MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPPKVILPRGGSVLVTCSTSCDQPTLLGIETPLPKKELLLLGNNQKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKDLTLRCQVEGGAPRANLIVVLLRGEEELKREPAVGEPAEVTTTVPVEKDHHGANFLCRTELDLRPQGLKLFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQWLTCAVILGTQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPPGPRTQFLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPVGESVTVTRDLEGTYLCRARSTQGEVTREVTVNVLSPRYEFVIIAVVAAAVIMGTAGLSTYLYNRQRKIRKYRLQQAQKGTPMKPNTQATPP
What is the function of this protein?
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).  During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
What are the official names of this protein?
Intercellular adhesion molecule 1, ICAM-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DNLI2_METMA
Sequence: MTSFREFAETCQAIEKISSTIETTNKVADLLKKVDVEELPVATHFIMSEVFPAWSGEQLGIGTSLLYVSLSKASGMSIHSIESLVRTTGDIGDTALLILKEKRKNQVTFSSFFEEKPELSITEVYRRFKIASEASGKGSQDIKVKNLQFLFTSSSPREAKYISRLALEELRIGVGEGVVRDAIAKAFSVPAEIVEHSFMVTNDLGIVAAAAKKGGVEALERLGIEINRPIKMMLSQISPDIDADIRAMKEVAIEWKFDGARVQIHKDGNSVTLFSRKLENVTSSLPDLVEIVRKHVKAESAILDGEAVAVDENGVPRAFQEILKRFRRKYDVREKALGIPIQLNFFDIMYINGKTLIDLPLLERRKALESCVESSVEDSKSISVAEQVITGDLELVEKIYREALKAGHEGVMVKNPNSVYSPGKRGKNWLKKKPLMDTLDLVIVGAEWGFGRRANLIGSYTVACYDPDTTRFLQVGKVGTGLTDDQLKELTEILSGLMEGGEAGGVFAIRPKVVLEIAFEEIQKSPNYDSGFALRFPRFIRIRDDKDPEEADTIQRIGRVYSQQLKRL
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase 2, Polydeoxyribonucleotide synthase [ATP] 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: FEN1_PLABA
Sequence: MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNESGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLIKAKEENLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYEMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPANFKYVEARQSFIKPKVLEKSEVKIDWCEPKIEELKKFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEENQKEVLKTKSKGKKREINNDNSTKLNAKKKKTNVKDEKKNNEKVDEPKNKPNENLVKDEDDQDDYDQNIFDERTNSESGNIKNENVKEDISSSDITMDIPKCINDIVC
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: HISZ_ANADF
Sequence: MLDLSLPSGLRDLLPDHSAHLAELSAKLQEVFSQFGYRRLFLPTLERLDVVERGLSAAALADVMKFVEPGSGEVVAIRPDITPQIARLYAARPDALPSPARLCYDGPVLRAREARAGRPREVYQAGVELLGAGGASADAEALVVLARALERVGLGSAVVEVGHARFAHAVIDAAGLAPKARGAAWDALSRKDEGALAALARRARGSAGARAALPELATLYGDGALARARALARQVPGAAAALGEVEAALRLARRRGVEAVSVDLGETRGLGYYTGVTFAGYAPGAGSAVAAGGRYDELLARFGRPGPAIGFAVDLEFATQALERANGRAKRPARPRRSPPRPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP283_ARATH
Sequence: MFRLKPLISVDLNQTMSLLRRFVKEANNSRFLLQSISGRSFSTVNPNPTASPGRRTCVEFDNLIFKAGSSGDFEAVRRLLNSRVVNACFNTTATFKFLTNTDSYSSSLEDLRRILPQTDAGYTRKHSYETLIARLCKLGRIDDALVLINDMAIGEFGLSTCVFHPILNTLTKKNRIEEAWRVVELMRSHAIPVDVTSYNYFLTSHCYDGDVAEASRVLRKMEEEEEGVMSPDTRTYDALVLGACKSGRVEAAMAILRRMEEEGLSVLYATHAHVIGEMVESGYYALSVEFVMAYAGKDKRLDEENLGSLASKLIKRKRFKEAKMVLKEMSVRGLRMGDALREFHEKNVLQS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g56030, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UPPP_CROS8
Sequence: MTDMHSLLVAAILGIVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGHPPHEGVGKGRLSLIHILLGMVPAVVLGLVFHDFIKSLFNPINVMYALVVGGVLLIIAEVLKPKEPKAPGLDDMTYRQAFFIGCFQCLALWPGFSRSGATISGGMLVGVSRYAASEFSFLLAVPMMMGATALDLYKSMGFLTMADLPMFAVGFVTAFVVALVAIKTFLHIIKRISFIPFAIYRFIVAAAVFAVFM
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATP6_ACACA
Sequence: MIFNPLEQFRISVLQKLFFGNIDISITNNTIILFVILIGFTFLFYVNYSTNTYIPSKWQYAVENIYLFVLQLFKQQINNIVALKYFPLVLFVFSFILFANLIGLLPYGFTITGHIIFTFQIAFSLFFGITLINFFNNKTEFFNLFVPSGVPKPLIPFLVVIEVVSYLIRPFSLSVRLFANMLAGHTLLNILSAFIFNVFKKYALISFLPLLFIVFIIVLEFCIAIVQAYIFSILTCIYLNDIYNTSH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PAPD7_MOUSE
Sequence: MSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDSESTLGRIIKVTQEVIDYRRWIKEKWGSRILPSPDLDNRIKIKERITTCNGEQMQSREPSSPYTQRLTLSLSSPQLLSSGSSASSVSSLSGSDIDSDTPPCTTPSVYQFSLQAPTTLMASLPTALPMPSSKPQPAASRTLIMTTNNQTRVTIPPPTLGVAPVPCRQAGVDGTTSLKAVHSVTSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHNHTQGGGYSSVGSGAVRPPVGNRGHHQYNRTGWRRKKHAHTRDSLPVSLSR
What is the function of this protein?
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity).  Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism.  Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates.  Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (By similarity).
What are the official names of this protein?
Terminal nucleotidyltransferase 4A, DNA polymerase sigma, Non-canonical poly(A) RNA polymerase PAPD7, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.
Protein: PSD_ACIBY
Sequence: MSFTSRLKKELFIKAQNLVPQHQLSRVVGKVAASENPILKAAVIHAFKTKYGIDLSIAEQGNALKYKSFNDFFTRALKDGVRLVDENPDSIVSPADGAISQIGKITAGEVFQAKGQSFSVEKLIGDPQLAQPFQEGEFATVYLSPRDYHRVHMPFSGTLTETLYVPGELFSVNQVTAENVPGLFARNERMVCLFDTELGRMAVVLVGAMIVAGIETVATGKVKPSGRIELQHHELKLEKGAELGRFYLGSTAIILFEKDKIEWEKRFKAESVVVMGERMGHTL
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MIAA_CLOK5
Sequence: MKKLFILAGPTAVGKTDISIEVAKKIDGEIISADSMQIYKYMNIGSAKITKGEMQEIPHYLIDIIDPKENFNVSRYKNLAEKTIEDIYSRNKFPMLVGGTGLYINSLICNYDFTDAKVDVNYRNYLENLAKVQGREYVHSLLKDIDAVSYERLYPNDLKRVVRALEVHKLTGKTIGEFNSKDSLYDIPYKIYYFVLNMDRVKLYERINKRVDLMIEQGLIDEVKNLRSMGYTKDMQSMKGIGYKELIRYLEGDISLDEAVYLIKKGSRNYAKRQLTWFRKDERVIWVNKDEFTSNKEIVNYIINTLVTC
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RPOA_CHLAB
Sequence: MSDCSQNLLYDKFELPESVKMMAVEGSGGSVDKQASFIAEPLERGMGHTLGNALRRALLIGLEAPAIISFSMTGVLHEYMAINGIIEDVTNIILNLKGALLKKYPFQDSENGRCTQLLKSKVSIDASDLAACGGQKAVTLADLLQEGGFESVNPDYVIFTVTQPMQLDITLRVAFGRGYTTSERIVLEDKGVNEIVLDAAFSPVVLVNYFVEDTRVGQDTDFDRLILHVETDGRVSPKEALAFSTQILTKHFSIFEKMDEKKIVFEEAISLEKENKDDILHKLVLGINEIELSVRSTNCLSNANIETIGELVIMPEPRLLQFRNFGKKSLCEIKNKLKEMKLELGMDLSQFGVGLDNVKEKMKWYADKIRSKNGKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MOAC_SYNS9
Sequence: MQSDRNLSHLNSKGDVHMVDVGDRPSTFREAHAQGSIQMDRETFDLILRGETPKGDVLAVARIAAIQAAKRTWELIPLCHPISLSGMDVDIQPAEHLPGLRLNCRCRTTGPTGVEMEAMVAVSVGLLTLYDMLKAVDPAMTIGSIQLIHKSGGRNGVWNR
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: Y1468_METJA
Sequence: MKLLKILMPLIILGIISIVNGYVIVIHPNTMNITNSSGVYNTDPNIIAYNVNDTITFEALAPDSVAQDILDNGVVKWDFGDLTETDYGNYRTTTHTYTFPFPYPVAWCGYLNNTGYSKALTYNWLVVGDVANTKYVFNGSPLNSKTSWEVYYNSTNNTVIIKYYSETPVDREFNGLSVDTTSVTVNVSRDEIVEGDTVKFNFSVSRNIIFCVWSFGDGTFSFEKFPEHTYTKSGLYYPRVLVVDDSGRVMVGYLDEGIEVKRARGGYIYWVTGPSHYDGEAYTYVYNSSGDDNNNNGNAYTDPYKITYKVNDTIKFEMSGAWGEYWKWDFGDGTETPYTYKSYFTPSYHQYKFPFMWPFFWMSYGWGSWWKSDTLNFIVVDDVENTRYNFYPSSAHDKTYYDYEYNKENHTVNLYYYSDVISTPKFNVKLRDGYYIDITATADKTQVSVNENVRFDCSPYGNPIFIMWCFGDGTCSFEKSPTHRYSSSGLYYPHVFVIDDNGNIEVGIPPPIGVGGYSSYPQIYASPTIAPTYYPINITIVEPASWTWYWHHIYFGDGGSVWIKPKKSPYTFTHTYTSEGVYPIYMKVYTAENMKTVYVIDNKNPIAKLYIYPNPASYKDTISFSPINSYDPDANRMIPEYNYYGTLIGYYPISPNSPMARIYGFNLTVYDSNGNVAWNYSSNELTIISKSFPIGNYTAKLVVWDGMGGVNSTTVKFSVINRPPVAQFIYYPDKPEPNEDVEFVSQSYDPEGEIAYYIWNFGDGTVINTTDTIVHHKYERPGYYTVTLTVFDKYNASSSISKQIVVGGILANFTYEIINENTVRFEDTSVVAPGKIISWHWDFGDGSTSTEQNPIHTYSKEGAYFVTLTVKSDTNLTDSVTKIVIISPPPKYPPVADFTYKVINGTTVEFNANLSYDEDGYIKYYIWDFGDGTPANTTTNPIIIHKYKKEGVYPVTLTVIDNDNLSDSRTKLINIGESFIHSVPIPPYIEILIVISTIFCFFQIIRGLK
What are the official names of this protein?
Uncharacterized protein MJ1468.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSMA_MANSM
Sequence: MNSKRHLGHTARKRFGQNFLHDDNVIQGIVAAIYPQKGQFLVEIGPGLGALTEPVADQTDRLTVVELDRDLAQRLRHHPFLHQKLNVIETDAMQFDFGKLYEDEHLAEQGQKLRVFGNLPYNISTPLIFHLLKFYDKIQDMHFMLQKEVVKRLCAAPNSKAYGRLTIMTQYFCQVMPVLEVPPTAFKPAPKVDSAVVRLIPHKELPHPVKDLYWLNRVTSQAFNQRRKTLRNALSTLFTPEQLTALNIDLTARAENLSIADYARLANWLADNPPADVRRDEIIEENEE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METJ_ECO55
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_PARUW
Sequence: MFYSFCKVGQYMTYFKFELIHRSKKSRARVGRIHTPHGIIDTPNFVAVGTNGTVKALNNTMLHDIGLQLMFCNTYHMMLQPGTDIVRQAGGLHSFIQRKLPIITDSGGFQVFSLAYGSVADELKSRGTKKQGGCVLKITEEGVLFRSYRDGSKVLLTPESSIKAQKDLGADIIIPFDELPPYHIARDALKKSLDRTHRWEKRSLEAHLKNPQEQAMYAVVHGGIDPDLRKESCAILTELPFDGFAVGGSMGKTKDEMHTLLSLTLPLLPEDKPNHLLGIGDLPSIERSVPLGIDTFDSSYPTRAARHGILLTKQGPLNITKSEYATNFNSIEKGCLCPACHHFSLAYIHHLFKARELTCMSLATVHNLYFMVQLMEKYRKQIQEDLI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CYB_AKOSP
Sequence: MKILRKNHPLLKIVNHSFIDLPTPSNISSWWNFGSLLGMCLMIQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYVLSETWNIGIILFLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAFALVHLLFLHETGSNNPSGLNSDSDKIPFHPYYTTKDLLGIFLLLLVLMILALFFPDILGDPDNFTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAAFPLLNNSKQHGLIFRPITQVIYWIFIANLLVLTWIGGQPVEYPFTMIGQIASITYFAIIIILIPISNTIENNIIKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZRG8_KLULA
Sequence: MRSFIKTHKRASSLDNSPRKSSNESPENRRNSQGSFGTELSYPSGYPPNNVLKQSSSFEPLHKLTSNKIFSSKLFKKSSNGKTSSSNTSPLLSRSDAETFAPLLSNTNNIPAIKGTRKHEWGDNDDTSESVILLNRTSMSSMSDTNQDTPDTEIVRIHPNSQQGSILSSQTSADRTPRLSLEEAEDVEDYDITKHSSLSRSQSLKKKRNRLARIHSHDDIMHLRSQSSFSSDLLGSGFSPIPEKSPNPSPLPKYERSPRKENNILDRTNLFDLRKISEASYTAEDESNFNRPFTGVAGGETIQITTSIKDSFVPSPETSHKIRFAADNVIPLSKAQIIENSASEADEDDSNEEDGEEESDSSSRFSFENGNDLCGRTASLKYYSTETNTPPLYVNDIYENDNFDDEMNYFDSNEEEDENMDHLYGGDNTALSGFAGMCTLSDDEFDRTNAAISQELSSHSSQSSKGYTERQRGFSKRDSNKSFEDGNDDYDPSNHCRSYHDIYNLSDEEEAQTINKKVTEPRKRKISDGTNKVTKYADMFLLSDDDAESGSQDEDFGDESRENDVKFNVNSERYGVEHTNLVTTQNHNLNPISFKSPSRFLDVSNVNHSPLAYKTPERNILKSPLQQPIKYHGVSSLLDNDIQGTMKNLYYIDETDEDRFLENSAESEEYYLDEINGIPEDFEFSDDENIMRNLSPLSRLNRTKLLAFRRTHSYSDRPLGVLKDNTPLNYKLEIKNKTVTFFDHNSIHRSYSEPFSSSLLHDSRKSEDNCEDRILDNKTLASPVTPNSSFTKPSPSFTQNSSLSPIQESTTSSDASPKIL
What is the function of this protein?
Involved in maintenance of polarized growth and daughter-cell-specific transcription.
What are the official names of this protein?
Zinc-regulated protein 8.
What is the protein family that this protein belongs to?
Belongs to the ZRG8 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud. Bud neck. Bud tip.
Protein: PETH_IDESA
Sequence: MNFPRASRLMQAAVLGGLMAVSAAATAQTNPYARGPNPTAASLEASAGPFTVRSFTVSRPSGYGAGTVYYPTNAGGTVGAIAIVPGYTARQSSIKWWGPRLASHGFVVITIDTNSTLDQPSSRSSQQMAALRQVASLNGTSSSPIYGKVDTARMGVMGWSMGGGGSLISAANNPSLKAAAPQAPWDSSTNFSSVTVPTLIFACENDSIAPVNSSALPIYDSMSRNAKQFLEINGGSHSCANSGNSNQALIGKKGVAWMKRFMDNDTRYSTFACENPNSTRVSDFRTANCS
What is the function of this protein?
Involved in the degradation and assimilation of the plastic poly(ethylene terephthalate) (PET), which allows I. sakaiensis to use PET as its major energy and carbon source for growth.  Likely acts synergistically with MHETase to depolymerize PET (PubMed:26965627).  Catalyzes the hydrolysis of PET to produce mono(2-hydroxyethyl) terephthalate (MHET) as the major product (PubMed:26965627, PubMed:32269349, PubMed:29666242, PubMed:29603535, PubMed:29374183, PubMed:29235460).  Also depolymerizes another semiaromatic polyester, poly(ethylene-2,5-furandicarboxylate) (PEF), which is an emerging, bioderived PET replacement with improved gas barrier properties (PubMed:29666242).  In contrast, PETase does not degrade aliphatic polyesters such as polylactic acid (PLA) and polybutylene succinate (PBS) (PubMed:29666242).  Is also able to hydrolyze bis(hydroxyethyl) terephthalate (BHET) to yield MHET with no further decomposition, but terephthalate (TPA) can also be observed (PubMed:26965627, PubMed:29603535, PubMed:29374183).  Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters) in vitro (PubMed:26965627, PubMed:30502092).
What are the official names of this protein?
Poly(ethylene terephthalate) hydrolase, PET hydrolase, PETase, PET-digesting enzyme.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPF_ANAMM
Sequence: MITAVRAVPFRVGIGYDVHGFADSPPENGHIVLCGVEIAFHRKIKAHSDGDVGTHALVDALLGCVGEGSIGEHFPNTDPRWENMSSTHFLLEAQSKALAKGYAVLNFDLTIVCELPKIIPHVPKMKLFMSKLLGMDASAINIKAVTTEKLGFIGRGEGIAAHAVVLCRKVTAAAPNPGSENPRG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.