PharMolix/UniProtQA huggingface dataset:
Protein: RFBP_SALTY
Sequence: MDNIDNKYNPQLCKIFLAISDLIFFNLALWFSLGCVYFIFDQVQRFIPQDQLDTRVITHFILSVVCVGWFWIRLRHYTYRKPFWYELKEIFRTIVIFAIFDLALIAFTKWQFSRYVWVFCWTFALILVPFFRALTKHLLNKLGIWKKKTIILGSGQNARGAYSALQSEEMMGFDVIAFFDTDASDAEINMLPVIKDTEIIWDLNRTGDVHYILAYEYTELEKTHFWLRELSKHHCRSVTVVPSFRGLPLYNTDMSFIFSHEVMLLRIQNNLAKRSSRFLKRTFDIVCSIMILIIASPLMIYLWYKVTRDGGPAIYGHQRVGRHGKLFPCYKFRSMVMNSQEVLKELLANDPIARAEWEKDFKLKNDPRITAVGRFIRKTSLDELPQLFNVLKGDMSLVGPRPIVSDELERYCDDVDYYLMAKPGMTGLWQVSGRNDVDYDTRVYFDSWYVKNWTLWNDIAILFKTAKVVLRRDGAY
What is the function of this protein?
Is responsible for transferring galactose-1-phosphate to the lipid precursor undecaprenol phosphate in the first steps of O-polysaccharide biosynthesis.
What are the official names of this protein?
Undecaprenyl-phosphate galactose phosphotransferase, Galactosyl-P-P-undecaprenol synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial sugar transferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPA_ECO27
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP171_BOVIN
Sequence: MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKITVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMIIPIKDIKEKPNVGCMEFKSEFGRNWHLLTNFISIAIFFNFSAIILISNCLVIRQLYRNKDNENYPNVKRALISILLVTTGYIICFVPYHIVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKITETFASHKESKAQKEKPRSENNA
What is the function of this protein?
G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N).  Acts through a G(i)-alpha-mediated pathway in response to bigLEN.  Big LEN-GPR171 system plays an important role in regulating feeding and metabolism.  Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala.  Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception.  Acts as a negative regulator T cell function.
What are the official names of this protein?
G-protein coupled receptor 171.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus.
Protein: PIGE_SERS3
Sequence: MKFGFIAHPTSVGLKRYVKMIDLLQRNSTELHSGYKRDLWRRENLVPFMNFAKITSATGATCEGVIKYMPLVADEMLADARGIANRVVSGIEELVEDGAELVGLGGFTSIVGRRGEATAEKSPVPVTSGNSLTTYAGYKALMQIQSWLDIQPEQEPVAIVGYPGSICLALSRLLLAQGFSLHLLHRAGHKDEDELLSHLPEQYRSRVTLTSDPEDLYPRCKLFVAATSAGGVIDPYKLQPGSVFIDVALPRDINSDTRPDRDDILIIDGGCVTATDAVKLGGESLNVTIKQQLNGCMAETIVLALENRRENFSLGRYLALDNVLEIGELAEKHGFLVYPLASYGERIDRQRVINLKRYYHHDIYSDEPDTEQPPASQLAFIDAIIAQDPAREDTLDRYHQFINPMMVEFLKLQHCDNVFRRASGTQLFTADGEAFLDMVAGYGCINLGHNPQPIIDALKAYLDAQGPNFIQYISIPEQAAKLAEVLCHFAPGNMGRVFFSNSGTEAVEAAMKLAKASTGKAGIAYLKNSYHGKTLGALSITGREKHRRHFKPLLASMIEVPFADIEALRQTLSRDDIGALMIEPIQGEGGVHVPPPGYLRTVQEICRQTDTLLMVDEVQTGLGRTGKLFACEWEGIEPDVLMLSKSLSGGVMPIGATLCRAIFGNGPYGTADRFLMHSSTFGGGNIAAVVALSALREILAQDLVGNAERLGTYFKQALTDVAARYPFVAEIAGRGLMLGIQFDQTFAGAVGASAREFATRLPGDWHTTWKFLPDPVQAHLKAAMERMEQSLGEMFCMKFVTKLCQDHNILTFITANSSTVIRIQPPLTISKAEIDRFVSAFATVCDELSTFLE
What is the function of this protein?
Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig).  Catalyzes the transamination to the aldehyde group of 3-acetyloctanal, resulting in an aminoketone, which spontaneously cyclizes to yield the dihydro form of MAP (H2MAP).
What are the official names of this protein?
Aminotransferase PigE.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: PUR9_SALNS
Sequence: MQQRRPVRRALLSVSDKAGIIEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEQHHIAPIDMVVVNLYPFAETVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDANEGSLTLDTRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKQDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVAVSTSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASGEALKITAAKQNVRVLTCGQWAQRVPGLDFKRVNGGLLVQDRDLGMVSEAELRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYAKENMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSAMASDAFFPFRDGIDAAAAVGVSCVIQPGGSIRDDEVIAAADEHGIAMIFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: HSCA_ACIBY
Sequence: MALLQIAEPGQSSAPHQHRIAIGIDLGTTHSLVATVLSGKPKVLNDVQNRRLLPSIVHYGDNTTHYGEEAKPFIIADPKNTIVSVKRFMGRSKADIKFQHPYELVGSENEMPAFETRAGRKTPVEISAEILKQLKDRAEDSLQNPVNGAVITVPAYFDEAQRQATRDAAQLAGLNVLRLLNEPTAAAVAYGLDQESNLATDRNYVIYDLGGGTFDVSILRFSQGVFEVLATGGHTALGGDDLDRLIVKWAKKQLNIDVLSDEDYAVFIVAARQAKEQLSTQDSVELKLLEATLTLDRPTFESIIQVALDKTISVCKRVLRDAKLELTDIQNVVLVGGSTRSYAVQKAVREVFAQEPLCTINPDEVVAIGASITANQLIGNSQDGSLLLDVTPLSLGLETMGGLVERLISRNTAIPVARRQEFTTYQDGQTAMLIHVVQGERDLVEHCRSLGRFVLHGIPPMTAGQARIEVTFQVDADGLLTVSAREATSGVQAHIDIKPSYGLSEADTERLLIEGFQHAEEDKNLRHLKETKVEAERELESLEQALKVDADLLDEKQLDALNSAKESLKAQLEGSDIQAIEHAVQQLKVHSDAFAALRMNRHIDHALKGTKLDDWSKSN
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MURE_SYNE7
Sequence: MNLRSLLASTPTQVLQPQHAALDLAITGLQTDSRRCQPGDLFLGMPGTQVDGGQFWPEAIAAGAVAVIVTPTALAQRPLSANPEACLILSDQMPVTAGAIAAAFYNQPAQTLKLIGVTGTNGKTTTTHLVEHFLNAADTKTALLGTLYNRWPGYSEVAQHTTPFATDLQAQLATAVDAGCQAAVMEVSSHALDQGRVNGCGFDVAVFTNLTQDHLDYHGTMEAYFAAKARLFAPPYLRGKAVINADDAYGQRLITMTPPGQCLTYSVVGTADFCTTDLQYGPTGVEGTIKTPDGAFPFRSPLVGQFNLANLLGAIAAGWTLGLPIETMLAVVPDFVGVPGRMERVVGQDSDPTVIVDYAHTPDSLENLLKAARPFIQGELICVFGCGGDRDRTKRPLMGEIAARLADRVIITSDNPRTEDPRQILADIVAGIPAASPVVVEADRAAAIRQAILSAQPGDGVLLAGKGHEDYQILGTTKIHFDDREQARLALAERQSA
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCC4_HUMAN
Sequence: MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL
What is the function of this protein?
Plays an important role in the loading of the cohesin complex on to DNA.  Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566).  Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).
What are the official names of this protein?
MAU2 chromatid cohesion factor homolog, MAU-2, Cohesin loading complex subunit SCC4 homolog.
What is the protein family that this protein belongs to?
Belongs to the SCC4/mau-2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus. Chromosome. Note=Binds to chromatin from the end of mitosis until prophase.
Protein: TYSY_SHESW
Sequence: MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGETNIAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKAQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTVLQLSREPKPLPLMTILRKPESIFDYQFEDFELTNYNPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_OSTNU
Sequence: MSRKWLYSTNHKDIGTLYFIFGIWSGMVGTSLSLLIRAELGNPGSLIGDDQIYNTIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLISSSIVENGAGTGWTVYPPLSSNIAHGGSSVDLAIFSLHLAGITSILGAINFITTIINMRINGMSFDQMPLFVWSVGITALLLLLSLPVLAGAFTMLTTDRNLNTSFFDPAGGEILFYIQHLFWFFGHPEVYILILPGFGMISMLFHKKEEKKKHFGSLGMIYAMMAIGLLGFVVWAHHMFTVGMDIDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQINYSPSILWSLGFVFLFTVGGLTGVVLANPSIDIALHDTYYVVAHFHYVLSMGAVFAIIAGFIHWYPLFTGLSLNPYFLKIQFFTMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYISWNIISSLGSYISLLAVMLILIIIWESMINQRMILFSLNLTSSMEWYKSKLPPAEHSYNELPILSNF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DCTA_SALG2
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHYYPELGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAQAVAVYAAQAKEQGIIAFLMDVIPGSVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGSLVQLGQLIICFYITCILFVVVVLGTIARVTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKELDHQKLDDVLNNRAPDGKTHEISF
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ICEV_PSESX
Sequence: MNIDKALVLRTCANNMADHCGLIWPASGTVESKYWQSTRRHENGLVGLLWGAGTSAFLSVHADARWKVCEVAVADIIGLEEPGMVKFPRAEVVHVGDRISASHFISARQADPASTPTPTPTPMATPTPAAANIALPVVEQPSHEVFDVALVSAAAPSVNTLPVTTPQNLQTATYGSTLSGDNNSRLIAGYGSNETAGNHSDLIAGYGSTGTAGSDSSLVAGYGSTQTAGGDSALTAGYGSTQTAREGSNLTAGYGSTGTAGSDSSLIAGYGSTQTSGEDSSLTAGYGSTQTAQEGSNLTAGYGSTGTAGSDSSLIAGYGSTQTSGGDSSLTAGYGSTQTAQEGSNLTSGYGSTGTAGADSSLIAGYGSTQTSGSDSALTAGYGSTQTAQEGSNLTAGYGSTGTAGSDSSLIAGYGSTQTSGSDSSLTAGYGSTQTAQEGSNLTAGYGSTGTAGVDSSLIAGYGSTQTSGSDSALTAGYGSTQTAQEGSNLTAGYGSTGTAGADSSLIAGYGSTQTSGSESSLTAGYGSTQTAREGSTLTAGYGSTGTAGADSSLIAGYGSTQTSGSDSSLTAGYGSTQTAQQGSVLTSGYGSTQTAGAASNLTTGYGSTGTAGHESFIIAGYGSTQTAGHKSILTAGYGSTQTARDGSDLVAGYGSTGTAGSGSSLIAGYGSTQTASYKSMLTAGYGSTQTAREHSDLVAGYGSTSTAGSNSSLIAGYGSTQTAGFKSIMTAGYGSTQTAQERSDLVAGYGSTSTAGYSSSLIAGYGSTQTAGYGSTLTTGYGSTQTAQENSSLTTGYGSTSTAGYSSSLIAGYGSTQTAGYESTLTAGYGSTQTAQERSDLVTGYGSTSTAGYASSLIAGYGSTQTAGYESTLTAGYGSTQTAQENSSLTTGYGSTSTAGFASSLIAGYGSTQTAGYKSTLTAGYGSTQTAEYGSSLTAGYGSTATAGQDSSLIAGYGSTLTSGIRSFLTAGYGSTLIAGLRSVLIAGYGSSLTSGIRSTLTAGYGSNQIASYGSSLIAGHESIQVAGNKSMLIAGKGSSQTAGFRSTLIAGAGSVQLAGDRSRLIAGADSNQTAGDRSKLLAGNNSYLTAGDRSKLTGGHDCTLMAGDQSRLTAGKNSILTAGARSKLIGSEGSTLSAGEDSTLIFRLWDGKRYRQLVARTGENGVEADIPYYVNEDDDIVDKPDEDDDWIEVE
What is the function of this protein?
Ice nucleation proteins enable bacteria to nucleate crystallization in supercooled water.
What are the official names of this protein?
Ice nucleation protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial ice nucleation protein family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: YQGF_SHEON
Sequence: MNAKTVLGFDFGTKSIGVAVGQQITASATPLLSIKAVDGIPNWEEIAKLIQEWQPDLVVVGLPLNMDGTEQEMTHRARKFANRLNAKFGVKIFTQDERLTTTDAKARLFELGGYKALTKGQVDAVSAVLIIESYFENHFGD
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_PSEA6
Sequence: MRTSQYLLSTQKETPADAEVISHQLMLRAGLVRKLASGLYTWLPTGLRVLNKVAQIVREEMDRAGSLEILMPVVQPADLWQESGRWDEYGPELLRIKDRHYRDFVLGPTHEEVVTALVKNEVSSYKQLPLNVYQVQTKFRDEVRPRFGVMRGREFTMKDAYSFHLSDECLNKTYDDMFAAYCRVFERINLEFRPVIADNGSIGGNASHEFHVLADSGEDDIAFSNASDYAANIEKAEALAPQFSRPAPSAELTKVATPNAKTIEQVSALLNIPAEQSVKTLIVLGEADNKGQQGLIALVLRGDHQLNELKAEKIDGVYAPLTMASEAQIEDTIGCSIGSIGPVGLNIPVIADRSAAVLADFVCGANENDVHYTGANWERDAKEFQEADIRNVQAGDPSPDGQGTLEIKRGIEVGHIFQLGSKYSEALNCGVLDENGKHQVLNMGCYGIGVSRIVAAAIEQNHDKYGIIWPDAIAPFKVAIVPMNMHKSHRIQQVAEDLYAQLKAAGVEVLFDDRKERPGVMFNDMELVGVPHTIVIGERNLDEQKVEYKNRRSGEKQLIDIPQLAEFVSTL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_VIBA3
Sequence: MEMNSLYIDGKAVDATSGETFVSINPANGEPIATLGQASSADVENAIESAKRGFAVWSAMTAVERSRILLKAVEILRARNNDLANLEVVDTGKPLQEAIEVDVASGADVIEYFAGLAPTLQGDQQPLSDTQFFYTRREPLGICAGIGAWNYPIQIAMWKSAPALAAGNAMIFKPSEETPLTALKLAEIFTEAGLPDGVFNVVQGDYRVGQMLTAHPDIAKVSFTGETGTGKAVMSDSAKTLKSVTMELGGKSPMIIFDDAKLDDAVSASMVANFYTQGEVCTNGTRVYVHESIYNDFIDQLKTRTEKLIIGNPMDMETQIGALISKEHLSKVLEAIELAKQSGATLLTGGYQVTDNGLANGNFVIPTVFTDCHDDMPHVQQEIFGPVMSVLKFTDEDDVIRRANDTQYGLAAGVFTQNLSRAHRVIHQMQAGICWVNTWGDSPAEMPVGGYKLSGVGRENGPETLLHYTQTKSILIELGDYASPYA
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CLN6_HUMAN
Sequence: MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH
What are the official names of this protein?
Ceroid-lipofuscinosis neuronal protein 6, Protein CLN6.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: Y358_ACIF2
Sequence: MAITDWPVDERPRERLLQKGAATLSDAELLAIFLRVGVVGKSAVDLAREMLLNFGSLRALLTASHHDFCVHKGLGDAKYALLQAVLEMGRRHLAEEWQRGDGLDSPLRVRQYLSATLRDRCREVFAVIFLDNRHRVLRFEEMFLGTIDGATVHIREVLKRALELNAAALIVAHNHPSGVAEPSAADLSLTRRLDQAMQLLDLRLLDHFIVGDGEPLSLREQGGW
What are the official names of this protein?
UPF0758 protein AFE_0358.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MSRB6_ARATH
Sequence: MNTSPKMEMEMKMETKAAPEAGMIKKSNEEWRTVLSPEQFKILREKSIEKRGSGEYVKLFEEGIYCCVGCGNPVYKSTTKFDSGCGWPAFFDAIPGAINRTEERAGLRYEITCTKCDGHLGHVLKNEGFPTPTDERHCVNSVALKFSSAITSQ
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  MSRB family specifically reduces the MetSO R-enantiomer (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase B6, AtMSRB6, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CLSA_PSEAE
Sequence: MAATGVDKDRPRAMTSTTYLGLLLVGIQVLGFVAAIHAVLTVRTAQGAIAWATSLVFMPYLTLLPYLVFGRSRFDAYIEARRQANREMHLAAAELDWRPWVEEALAARQVSGYKGLKALVRMTRTPTLANNRVRLLVNGEASFEAMFKAISAARQVILVQFFIVRDDALGQRLQQLLLERAANGVEVFFLYDAIGSHALPHRYVERLRQGGVQMHGFSTGSGMLNRFQVNFRNHRKVVVVDGECGFVGGHNVGVEYLGEKPPLAPWRDTHMELRGPAVACLQESFAEDWYWATHSLPPLILPPQYDSEGALCQVVASGPADAQETCSLFFVEMINAAHERVWITSPYFVPDEAVMAALRLAVLRGVDVRLLIPSRPDHRTVYAASSLYALEAIRAGVKVFRYQPGFLHQKVVLVDRDTAAVGSANLDNRSFRLNFEVMVVTVDEGFAGEVEAMLEADFAESLEFTPEDRRSVRRLQQLGMRVARLVSPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BCSB_ECOLI
Sequence: MKRKLFWICAVAMGMSAFPSFMTQATPATQPLINAEPAVAAQTEQNPQVGQVMPGVQGADAPVVAQNGPSRDVKLTFAQIAPPPGSMVLRGINPNGSIEFGMRSDEVVTKAMLNLEYTPSPSLLPVQSQLKVYLNDELMGVLPVTKEQLGKKTLAQMPINPLFISDFNRVRLEFVGHYQDVCEKPASTTLWLDVGRSSGLDLTYQTLNVKNDLSHFPVPFFDPSDNRTNTLPMVFAGAPDVGLQQASAIVASWFGSRSGWRGQNFPVLYNQLPDRNAIVFATNDKRPDFLRDHPAVKAPVIEMINHPQNPYVKLLVVFGRDDKDLLQAAKGIAQGNILFRGESVVVNEVKPLLPRKPYDAPNWVRTDRPVTFGELKTYEEQLQSSGLEPAAINVSLNLPPDLYLMRSTGIDMDINYRYTMPPVKDSSRMDISLNNQFLQSFNLSSKQEANRLLLRIPVLQGLLDGKTDVSIPALKLGATNQLRFDFEYMNPMPGGSVDNCITFQPVQNHVVIGDDSTIDFSKYYHFIPMPDLRAFANAGFPFSRMADLSQTITVMPKAPNEAQMETLLNTVGFIGAQTGFPAINLTVTDDGSTIQGKDADIMIIGGIPDKLKDDKQIDLLVQATESWVKTPMRQTPFPGIVPDESDRAAETRSTLTSSGAMAAVIGFQSPYNDQRSVIALLADSPRGYEMLNDAVNDSGKRATMFGSVAVIRESGINSLRVGDVYYVGHLPWFERVWYALANHPILLAVLAAISVILLAWVLWRLLRIISRRRLNPDNE
What is the function of this protein?
Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
What are the official names of this protein?
Cyclic di-GMP-binding protein, Cellulose synthase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the AcsB/BcsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein.
Protein: RS13_LACAC
Sequence: MARIAGVDLPRDKRIVVALTYIYGIGDATAKKICADAGVSEDIRSKDLTPEDQEKLRAEVDKYRVEGDLRREVSMNIKRLVDIGSYRGIRHRRGLPVRGQNTKNNARTRKGTKRNR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: GLMU_BACMK
Sequence: MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVNEVSQLGLQKLVTVVGHGAEKVQEQLGNVSEFALQAEQLGTAHAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHEEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIMKNRINRKNMVNGVTIIDPSNTYISTDAVIGSDTVLHPGTVIEGNTVIGSDCEIGPHTVIRDSEIGDRTVIRQSTVHDSKLGTVVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.