PharMolix/UniProtQA huggingface dataset:
Protein: RL33_KORVE
Sequence: MPREIIQLQCGDCKDKNYSTTKNKKTTTGRLEFSKFCRKCRKHTSHKEVK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TNPA_BACTU
Sequence: MGVKQLLSEAQRNELMDLSRLTEWDLVTFRTFSKHDLHLILKHRRGYNRLGFALRLVLIRYPGWSLTEYKDIPQYVVAYVTSRLRIPPEEFLVYAKRGNTLWEHLGEIRTEYGYQNFSSEYKETLLQFLVQQAMDNNNTLYLIEITISTLRKTKVILPAMYVIEDIVWEAKQQADQKVYSILHDGLVQEQKDQLDALLLPTINGKSPLAWLKDVPAQPSPESFLKVIDRLQFVQKIGLTIDTTKINTNRLRQLARLGSKYEPYAFRRFNEVKRYSMLVSFLLEITQDLIDYAIEIHDRLMMNLQTKGKKEQDEIQQANGKKLNEKILQFITVCGTLIEAKETGKDAFAALDEVMSWNEMVESVEEAKQLSRPLNYDYLDLLNTRYSYVRRYAPTLLRSLHFRATKSGEPVLQALDTIHELNETGKRKVPHGAPLHFVSNRWQKHVYDDDGNINRHYYELAALTELRNHIRSGDIFVSGSRHHKAFDDYLIPYDEWNEVSNIPNGLTAPLKAEDYITDRINRLNEHLEWLSKNSEKLEGVDISQGKLHVERLDRGTPEEAKAFSKLLHSMLPRIKLTDLLIEVASWTGFHDQFIHASTNQSPDQEEQNIVLATLMAMGTNIGLTKMAEATPGISYRQMANASQWRMYDDAMVRAQSILVNFQKEQKLSSYWGDGTTSSSDGMRLSIAVRSLHADSNPHYGTGKGGTIYRFVSDQLSAYHVKVITTNARDALHVLDGLLHHETDLKIEEHYTDTAGYTDQVFALTHLLGFRFAPRIRDLADTKLFSIPGGEEYENVQALLKGKINVKLIKENYEDIRRLAYSVQTGKVSSALIMGKLGSYARQNKLATALGEMGRIEKTLFTLDYISNKAVRRRVQKGLNKGEAINALARTIFFGQRGEFRERALQDQLQRASALNIIINAISVWNTVYMEKAVEELKARGEFREDLMPYAWPLGWEHINFLGEYKFEGLHDTGQMNLRPLRIKEPFYS
What is the function of this protein?
Required for transposition of transposon Tn4430.
What are the official names of this protein?
Transposase for transposon Tn4430.
What is the protein family that this protein belongs to?
Belongs to the transposase 7 family.
Protein: SYS_SPHAL
Sequence: MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQAMAAGDKDKAEALKAEVAALKAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEAGNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSGARFAFLKGPMARLERALGQFMLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVREQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELERKTRAAESILEALELPYRKMLLCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQARRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQQADGSVDIPAALLPYMGGITRLTPLG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPEL_BACC7
Sequence: MVVSKFVQIRRDLHKIPEIGFKEWKTQRYILDYIGTLSNEHVEVKVWRTGVIVKVKGKNPEKVIGYRADIDGLPITEETGYEFASVHEGMMHACGHDLHTTIGLGLLTAAVTERIDDDLVFLFQPAEEGPGGALPMLESEELKEWKPNIILGLHIAPEYPVGTIATKEGLLFANTSELYVDLKGKGGHAAYPHTANDMIVAASHLVTQLQSVISRNVNPLDSAVITIGKITGGTVQNIIAEKSRLEGTIRTLSVESMSRVKSRIEAIVAGIEASFQCEAIIDYGAMYHQVYNHEALTREFMQFVSEQTDMKVITCTEAMTGEDFGYMLQEIPGFMFWLGVNSEYGLHHAKLKPDEEAIEKAIVFLDQYVKWKGTRK
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: RECX_STRP7
Sequence: MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEEELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDENIVSQVIANLKEDKWINDGQYAYAIINTNQLSGDKGPYVLTQKLAQKGISKSTIEENLKEFDFSEVAQRVANKLLKKYEGKLPARALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVEQETTQELIFKELDKQYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_CELJU
Sequence: MAVEQTFSIIKPDAVKNNHIGAIVARFEKAGLKVIAQRMLQLTPAQAEGFYAEHKGRSFYDELVAFMTSGPVVVQVLYGENAIALNRELMGATDPTKAAPGTIRADFSMSMPANAVHGSDSPISAAREIAYFFPTHEVVVR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_RHILO
Sequence: MSKTKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGGELEPARKKAEMMGIKDIRIVDVREEFVADFVFPMFRANTVYEGTYLLGTSIARPLISKHLVDIARETGADAIAHGATGKGNDQVRFELSAYALNPDIKVIAPWRDWSFKSRTDLINFAEQHQIPVAKDKRGEAPFSVDANLLHSSSEGKVLEDPWSEPPEFVHQRTVSPMDAPDKVTEIEIEFLKGDPIALNGKKLSPATMLAALNDLGRDNGIGRLDLVENRFVGMKSRGVYETPGGAILIVAHRAIESITLDRGAAHLKDEFMPRYAELIYNGFWFSPERLMLQAMIDKSQEDVEGTVRLKLYKGNVMVTGRKSKKTLYSDALVTFEDDRGAYDQKDAAGFIRLNALRLRTLAARNRKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_CAMJR
Sequence: MQYSIEINKNTEIFNIDKVAKQAAGAVLMRQGKSVVLATVAREEKQVEEDFLPLTVQYIEKAYAAGKIPGGYVKRETKPSDAETLTARIIDRSLRPLFPKGYAYPTQIVVMVLSADPKVDLQVMSLNAASVALYLSDIPMKAPVCGVRIGKIDGNFILNPNNEELQNSTLDLYVAGVKDELLMIEMRALPDQKENEIFIEAPYADVLTQTTSQNMNELSEDEILEALNLAQKAILNGSNAYEEAFSKHKKNSQIELKNEIEYPEILAFIENNFQKQIKEAINQMAKSERASELNKIAKEISNLEIAKEWSEESVLNTLAKVKRKLIRGQILNEGKRADGRSLNEVRPISIETNILPNAHGSCLFTRGQTQALVVATLGGENDAQMIDLLTEKNPISERFMVNYNFPGFSVGEASPIKAPGRRELGHGNLAKRALYPSVDENYPYVIRLVSEILESNGSSSMATVCGGSLALKAAGVPSLKLVAGVAMGLIFEDNKYAVLTDIMGLEDHDGDMDFKVAGSKDGVTALQMDIKLGGIDQETLKQALYQAKEGRIHILNIMEEAAKEIIVNEEVLPKLELFSVDPSKIVDIIGQAGKTIKEIVEKFGVSIDLDREKGEVKIAGSQNEQIKAAKDYIINITSSQKGTKKGSKDKDISGFELGQEFQGIVKKIAPFGAFVELKNGVDGLLHSSKSKHLNLSENQSLKVKISEIKNGKISVDLCE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14E_THEGJ
Sequence: MPAIEVGRIAVVIAGRRAGQKVVVADIIDKNFVLVTGAGLNKVKRRRMNVKHLEPLPERVNIERGASDEEIKKALEEAGISLE
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: ISPT_CAUVC
Sequence: MPATTGPQDVSGRAGGPASTERLHVAIIMDGNGRWAKQRGMPRVLGHRAGVNALKRTVEGAQSQNVGVLTVFGFSTENWSRPPQEVSELMGLLKAYVESDLERLAKAGVRVRIIGRRTGLSPDIAEVIERAERRTAQNSEFVLQVAFNYGGQADITDAARAFAERVERGEAKASDLNEKTFEQFLSTASAPPPDLIVRTSGERRISNFLLWDCAYAELVFQDVLWPDYGPEALAAAIAEYRGRDRRYGGVAADDVAVAG
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: KU_DESHD
Sequence: MHTVWKGSISFGLVNVPVKMHAATETHEFHFNYLHKDCHNRIRYIKKCPHCEVEVAAENIIKGYEYEKDHYVIMEEEDLASLEAPLSRSIDILDFIDLSDIDPIYYQKSYYLSPEEAAHKAYKLLCQAMSDTGKVAIAKLTMRSKQHLACLRIIDQSIMVLETMYYPAEIRHLEASWDNVSPTDTEIAMARQLIENLAAPFAPEKYRDELREQVKELIEKKVSGETYRVAAAPEPGKVVDLMEALRASIAMTDQKKQQNTAESETEEKPTKSTLTPRGRRKVKGA
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: RNC_GEOMG
Sequence: MGERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEFLGDAVLGLLVGKMLFARFPQSREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEERSGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSPLLAGIASGATGRDFKTEFQEMVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARFAAEGEG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_ECOBW
Sequence: MRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYENATRDIAVLEDAGVPYQLLESSRLAEVEPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPVDQLLCDGEQIYGVKCGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGRTRFKNLWLNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPSRPGHLHGAHS
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: Y147_LISW6
Sequence: MAKANEHFFYVLKCNDNSYYGGYTTDVTRREAEHNAGIRCKYTKTRRPVKVIHFEKFETRSEATKAEAAFKKLSRKNKDSYLIEREEDSE
What are the official names of this protein?
UPF0213 protein lwe0147.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: USTD_ASPFN
Sequence: MKSVATSSLDDVDKDSVPLGSSINGTAQAETPLENVIDVESVRSHFPVLGGETAAFNNASGTVVLKEAIESTSNFMYSFPFPPGVDAKSMEAITAYTGNKGKVAAFINALPDEITFGQSTTCLFRLLGLSLKPMLNNDCEIVCSTLCHEAAASAWIHLSRELGITIKWWSPTTTPNSPDDPVLTTDSLKPLLSPKTRLVTCNHVSNVVGTIHPIREIADVVHTIPGCMLIVDGVACVPHRPVDVKELDVDFYCFSWYKLFGPHLGTLYASRKAQDRYMTSINHYFVSSSSLDGKLALGMPSFELQLMCSPIVSYLQDTVGWDRIVRQETVLVTILLEYLLSKPSVYRVFGRRNSDPSQRVAIVTFEVVGRSSGDVAMRVNTRNRFRITSGICLAPRPTWDVLKPKSSDGLVRVSFVHYNTVEEVRAFCSELDEIVTRDT
What is the function of this protein?
Cysteine desulfurase-like protein; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide (PubMed:24841822, PubMed:27166860, PubMed:26703898).  First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-terminal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) (PubMed:24841822).  Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI (PubMed:24841822).  To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline (PubMed:24841822).  One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH (PubMed:24841822).  Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F (PubMed:27166860, PubMed:26703898).  For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization (PubMed:27166860).  UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations (PubMed:27166860).  N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H (PubMed:27166860).  The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H (PubMed:27166860).  Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B (PubMed:27166860).
What are the official names of this protein?
Cysteine desulfurase-like protein ustD, Ustiloxin B biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein: Y490_RUMCH
Sequence: MAIFRDCSNIGKDRSAEDRRRHRELVEDSIKKNLGSIIAEESIIGKSKDKKIKIPIKGIKEFQFIYGKSKPGVGAGDGNEKRGDKFPGDSQEGKGKGNAGNSEGEEVYETEITIEEVIKYLFDDMNLPDIAKKQLSQLEEKSYRKLGYQHKGIPPRLAKKRSVIEKIKRKQASKRSEDGEDITHDKEYGKERFPFIEEDLRYYRIKEDNKRDYNAVVLCIMDVSGSMDQTKKYLARSFYFLLYQFLRLKYANVDVVFIAHTTTAKEVNEREFFHRGESGGTYISSGYEKALEIISERYSPTNWNIYAFHCSDGDNWSEDNRKAVESANKLCEVCNLFGYGEIVPGYYNIGSTIKNEFLNKIKSKNFAAININKKEDVLPALKKLLDKASDKDEKTGLK
What are the official names of this protein?
UPF0229 protein Ccel_0490.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: HIF1A_BOVIN
Sequence: MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWIETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLENSSTSPQSASTNTVFQPTQMQKPPIATVTTTATSDELKTVTKDGMEDIKILIAFPSPPHVPKEPPCATTSPYSDTGSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTAPEEELNPKILALQNAQRKRKIEHDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
What is the function of this protein?
Functions as a master transcriptional regulator of the adaptive response to hypoxia.  Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.  Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity).  Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).  Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300.  Activity is enhanced by interaction with NCOA1 and/or NCOA2.  Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.  Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity).
Protein: FEN1_PHATC
Sequence: MGIKGLAKLLSDEAPDCIREVELKSLHGRKIAIDASMAIYQFLIAVRSGGPNQQATMLTNAEGETTSHIQGMFNRTIRYMTEGIRPVFVFDGKPPDVKSHELIKRREKREKAQAALAVASEEGNVEEQDKQSKRLVRAGTKENEDCRKLLTLMGVPVVTAPCEAEAQAAALCKAGLVYATGTEDMDALTFATPILVRKLTFANASKSMVQTMNYNKVIEGLAISHDQFVDLCIMLGCDYCDTIRGVGPKTALKLIREHGNIEKVIETIDRKKFVVPESWVPNEKKLDAQSDDDDEEGVESPSKEENNGIVDTEELIPAYVQARKLFNEHEVLNDIELKWKPCQAEDLQKFLVDDMGFNVDRVKNNIEKLQAAYKANSKPQTRMDSFFAVKANPNAAKSAAKRKADAAKAKAAVSKKKTKKH
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: SC5A3_HUMAN
Sequence: MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL
What is the function of this protein?
Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity).  Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity).  Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel.  In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216).  Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108) (By similarity).  Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216).  Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553).
What are the official names of this protein?
Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NU3M_GORGO
Sequence: MNFALILMTNTLLALLLMIITFWLPQLNSYMEKTNPYECGFDPVSPARIPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILTLSLAYEWLQKGLDWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ERA_PSE14
Sequence: MNDTTATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGAVQAIYVDTPGMHKNGEKALNRYMNKTASAALKDVDVVIFVVDRTRWTDEDQMVLERVQYVQGPVILAINKTDRIEDKSDLMPHLEWLQGQLPNASIVPISAQHGHNLEALESLIASHLPENDHFFPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGRTLHIHALILVERDGQKKIIIGDKGDRIKRIGSDARRDMELLFDSKVMLNLWVKVKGGWSDDERALRSLGYGDL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: ANAG_HUMAN
Sequence: MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
What is the function of this protein?
Involved in the degradation of heparan sulfate.
What are the official names of this protein?
Alpha-N-acetylglucosaminidase, N-acetyl-alpha-glucosaminidase, NAG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 89 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: ICAM4_MOUSE
Sequence: MESALLLPSLLLVAAYPRGGSPQQEWMQSPPAPSVTSAPFWVRLNPELEAVPPGGSAWLNCSHNCPLPVHSSLRTQLRQGKIVNGSGWVSYQLLDVRAWNSKVRCVVTCAGETREATARITAYKRPRSVILEPPVLVGHKYTLRCYVTHVFPVGFLVVSLRRGGRVIYHESLERFTGSDLANVTLTYVMRAGLNDLWQPLTCHARLNLDGLVVRSSSAPVMLTVLALSPASIALASTSIATLVGILLAVGAVYVRKYLAVQT
What is the function of this protein?
Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2).  ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity).  Isoform 2 may modulate binding of membrane-associated ICAM4.
What are the official names of this protein?
Intercellular adhesion molecule 4, ICAM-4.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.