PharMolix/UniProtQA huggingface dataset:
Protein: SRYA_DROME
Sequence: MEQLLAQLHTCSELIAEGYSSTGNIGWLNEFCATFLDFASDLKARLPEVAPSGANLDVETIFLCLTQVVTCITHLERTISMEAPHMTRQHFLDRLDWCLRRLLVSLTQLEGNVTPVKNLEDHSFVELMDLALDHLDDYMEKLAQQRNNSLHILEESFTEDTYQLASIVNHIVRHALAFANVAIHSDKKALTALCETLLAECATFHEEAGEPNSGHRKLEALSLERALYALESFLNEALLHLLFVSLIDLENASVEKLKDALQRDPAGAQELISAFDTNMDRIQQIGVLAIAFSQDIKTKTIVRSCLASLESLDACIVPALQLPESTSSAHHAEVLQEHFNQELLIFRNVIHEIIDSCSLINNYLDMLGERIHVQDKSHLKLIVQRGGVVVDHFRLPVNYSGLSEDGKRVHKDLILILRECQAVVNLDVPVDPKRIVKRLKILYSVLAKLRDLICRDNLEPDSSVASEAQVPSSATRTFVRSSRSFGKRHRSFVKQTGNCSVFGPQDSLAESGHSESDLISFQITEILRLD
What is the function of this protein?
Required for the cellularization of the syncytial blastoderm embryo.  Involved in the localization of the actin filaments just prior to and during plasma membrane invagination.  Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
What are the official names of this protein?
Serendipity locus protein alpha.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Inner membrane-associated and cytoplasmic. Colocalizes with the structural transitions in the microfilament network during cellularization.
Protein: DXR_TREDE
Sequence: MGRKRVVVLGAGGSIGKNSLEIIRRFPDRFELAGFSVHSNSGFAKTLLAEFTDAQFVSTKKKNSNLKHEIDEEAVRRLIEKSKADIVINGIAGSAGLKASVEVIKSGLDLALANKETIVEAGELIFQDAEKSGSTIIPVDSEHAAIFQLINAHKKGNIEKIIITASGGPFLNTPREKLSTIKLEDALKHPTWKMGGKISIDSASLANKALEVIEAVKLFSFPPEKIEVTVHPQSIIHSMVQCKNGEIFAQASPPDMKNPILNALSFPKMPESFLKPLDFSQIIKLEFMPPRTDDFPMLALGFEAAGKGGAYPIAFNVANEEAVDAFIKGKIGFTDLADITQEVLNSDWTMKPSSYEEVYDYENRARAIALARILDRVNGLQ
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RS6_STRP3
Sequence: MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKDWEKRRLAYEINDFREGLYHIVNLEATDAAALNEFDRLSKINGDILRHMIVKLDA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: WALR_STAHJ
Sequence: MARKVVVVDDEKPIADILEFNLKKEGYDVYCAYDGNDAVDLIYEEEPDIVLLDIMLPGRDGMEVCREVRKKFEMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHYSQPAQEVSGTTNEITIKDIVIYPDAYSIKKRGEDIELTHREFELFHYLSKHMGQVMTREHLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDPSHPEYIVTRRGVGYFLQQHD
What is the function of this protein?
Member of the two-component regulatory system WalK/WalR.
What are the official names of this protein?
Transcriptional regulatory protein WalR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1761_METMA
Sequence: MEMRQPAVAGQFYPLRCENLENELKRCFEGLEIREQEVLGAVCPHAGYMYSGKVAAHVYATLPEADTYVIFGPNHTGYGSPVSVSRETWKTPLGNIDVDLELADGFLGSIVDADELGHKYEHSIEVQLPFLQYRFERDFKILPICMGMQDEETAVEVGNLLADLISESGKRAVIIASSDFTHYETAERAKEIDSEVIDSILNFDISGMYDRLYRRNASVCGYGPITAMLTASKKLGGSRATLLKYANSGDVSGDKDAVVGYAAIIVE
What are the official names of this protein?
MEMO1 family protein MM_1761.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: PUR2_BRUME
Sequence: MKVLLIGSGGREHALAWKLAASPLLEKLYCALGNPGIAAVAELADIGVDDHAALIAFAKEKHIDLVVVGPEAPLVAGLADEMRAEGIRVFGPSRAAAQLEGSKGFTKDLCARFNIPTGAYGRFNNAPKAKAYIRQQGAPIVVKADGLAAGKGVVVAMTLQEALDAVDSCFEGAFGAAGAEVVVEEFLDGEEASFFCICDGKTALPLGSAQDHKRVGDGDTGPNTGGMGAYAPAPVMTPEMVARTMRELIEPTMRGMAEIGAPFSGILFAGLMITSDGPKLIEYNTRFGDPECQVLMMRLNSDLLALVNAAVDGRLDEVSLEWKDEPALTVVMAAEGYPANVKKGSVIRDLEKLESIDGVKLFHAGTALKDGAIVASGGRVLNITATAATVAQAQARAYEALKLIDWPEGFYRSDIGWRAVEREKANR
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: LTI65_ARATH
Sequence: MESQLTRPYGHEQAEEPIRIHHPEEEEHHEKGASKVLKKVKEKAKKIKNSLTKHGNGHDHDVEDDDDEYDEQDPEVHGAPVYESSAVRGGVTGKPKSLSHAGETNVPASEEIVPPGTKVFPVVSSDHTKPIEPVSLQDTSYGHEALADPVRTTETSDWEAKREAPTHYPLGVSEFSDRGESREAHQEPLNTPVSLLSATEDVTRTFAPGGEDDYLGGQRKVNVETPKRLEEDPAAPGGGSDYLSGVSNYQSKVTDPTHKGGEAGVPEIAESLGRMKVTDESPDQKSRQGREEDFPTRSHEFDLKKESDINKNSPARFGGESKAGMEEDFPTRGDVKVESGLGRDLPTGTHDQFSPELSRPKERDDSEETKDESTHETKPSTYTEQLASATSAITNKAIAAKNVVASKLGYTGENGGGQSESPVKDETPRSVTAYGQKVAGTVAEKLTPVYEKVKETGSTVMTKLPLSGGGSGVKETQQGEEKGVTAKNYISEKLKPGEEDKALSEMIAEKLHFGGGGEKKTTATKEVEVTVEKIPSDQIAEGKGHGEAVAEEGKGGEGMVGKVKGAVTSWLGGKPKSPRSVEESPQSLGTTVGTMGFSDSGGSELGGSGGGKGVQDSGN
What are the official names of this protein?
Low-temperature-induced 65 kDa protein, Desiccation-responsive protein 29B.
What is the protein family that this protein belongs to?
Belongs to the LTI78/LTI65 family.
Protein: DXS_CROS5
Sequence: MNLSDITHPNQLHGLSNRQLEDIARQIREKHLQTIAASGGHLGPGLGVVELTIALYQTLDLDRDKVIWDVGHQAYPHKMLTGRYHRFHTLRQKDGIAGYLKRCESNFDHFGAGHASTSISAGLGMALARDAKGEDYKVVSIIGDGALTGGMALEAINHAGHLPHTNLMVVLNDNEMSISPNVGAISRYLNKVRLSDPVQFLSDNLEEQFKHLPFFGESLTPEMERVKEGMKRLAMPKVGAVIEELGFKYFGPIDGHNLEELISTFKQAHKAGGPVFVHVATVKGKGYELAEKDQVGYHAQSPFNLATGKAIPSNKPKPPSYSKVFAHTLTTLAQNDPKIIGITAAMATGTGLDKLHAKLPKQYIDVGIAEQHAVTLSAGLACEGMRPVVAIYSTFLQRAYDQVLHDVCIQNLPVFFCLDRAGIVGADGPTHQGLYDIAYLRCIPNLTIMAPKDEAELQRMVVTGINHTDGPIAMRYPRGSGVGVPLMEEGWEPVSIGKGEILRNGDDVLLVGYGTMVHQSLQVAEILKEHGIEATVVNARFVKPLDTELIVPLAQRIGKVVTLEEGCLMGGFGSAVAEALLDHDVVVPIKRFGVPDKLVDHAKPDESKADLGLTSPQIAEEIRQLFFNTPQPSAVS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: Y2273_MYCTO
Sequence: MNRHSTAASDRGLQAERTTLAWTRTAFALLVNGVLLTLKDTQGADGPAGLIPAGLAGAAASCCYVIALQRQRALSHRPLPARITPRGQVHILATAVLVLMVVTAFAQLL
What are the official names of this protein?
Uncharacterized protein MT2334.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOSB_STAES
Sequence: MEITSVNHICFSVSDLNTSIQFYKDILHGDLLVSGRTTAYLTIGHTWIALNQEKNIPRNEISHSYTHIAFSIDEEDFQQWIQWLKENQVNILKGRPRDIKDKKSIYFTDPDGHKIELHTGTLKDRMEYYKCENTHMQFYDEF
What is the function of this protein?
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin.  L-cysteine is probably the physiological thiol donor.
What are the official names of this protein?
Metallothiol transferase FosB, Fosfomycin resistance protein.
What is the protein family that this protein belongs to?
Belongs to the fosfomycin resistance protein family. FosB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_COXBU
Sequence: MKSSHPVNFQQMILALQEYWASQGCVLLQPFDMEVGAGTFHPATFLRAIGPEPWRAAYVQPSRRPTDGRYGDNPNRTQHYYQFQVVLKPSPDDIQDIYLGSLKALGIDPLTHDIRFVEDNWEAPTLGSWGVGWEVWQDGMEITQFTYFQQIGGLECKPVTGEITYGLERLAMFLQGIDNMFDLVWTEGPNGRVTYGQIFQQNEVEMSAYNFEYANVEALFNFFDFYEKEASQLIEVHLPLAAYEMVLKASHTFNLLDARQAISVTERQRFILRVRKLAQAVAEAYYSAREKLGFPMLEEISSSSSRVLPLAGNDRVKGC
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_YERPA
Sequence: MIEQPRICVQVHSIYVETQSIPEEERFVFAYTVTVRNLGRSNVQLLGRYWLITNSNGRQTEVQGEGVIGEQPLILPGNEFQYTSGAVLETPLGTMEGHYEMIDHLGQAFRTVIPVFRLAIPALIH
What are the official names of this protein?
Protein ApaG.
Protein: DNAJ_STRPY
Sequence: MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGSGAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQIRLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYSLDISFTQAALGDTVEIPTVHGDVELAIPAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAD_ECO55
Sequence: MMRQSLQAVLPEISGNKTSPLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDESLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_BRUO2
Sequence: MNSIPEGRPTPNLPRTANKRGVARLAAVQALYQMDVAGTGVMEVVAEYEAFRLGKEVDGTQYLDADPQWFRAIVAGVVEDQLKLDPMIHQALTEDWPLSRLDSTLRAILRAGAWELKARKDVPTAVIVSEYVDIAKAFYTEDEPKLVNAVLDRLALVIRGESRGAKPRHKS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: YFBU_SALPA
Sequence: MEMTNAQRLILSNQYKMMTMLDPTNAERYRRLQTIIERGYGLQMRELDREFGELTEETCRTIIDIMEMYHALHVSWTNLKDTQAIDERRVTFLGFDAATEARYLGYVRFMVNIEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: PI2R_MOUSE
Sequence: MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAACSLC
What is the function of this protein?
Receptor for prostacyclin (prostaglandin I2 or PGI2).  The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
What are the official names of this protein?
Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_CHLAB
Sequence: MQHARKKFRVGRTSAHNRCMLANMLKSLIHQERIETTLPKAKELRRHADKMITLAKKNTLAARRLAVARLMIRYNKLTSKEARQAKGGDLSVYNVDRKVINKLFDELGSRFVSRNGGYTRILKMQNRVGDNARKCIIEFLAN
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: CLPS_MYCA1
Sequence: MVVMSAPTEPKSRPGTTGQRESAPEDVTASPWVTIVWDDPVNLMTYVTYVFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSREAMEVDVSKLHAAGLWATMQQDR
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: NDKA_RAT
Sequence: MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFIQASEDLLKEHYIDLKDRPFFSGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEISLWFQPEELVDYKSCAQNWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.  Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression.  Required for neural development including neural patterning and cell fate determination.  During GZMA-mediated cell death, works in concert with TREX1.  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Metastasis inhibition factor NM23, Tumor metastatic process-associated protein.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYA_BACHK
Sequence: MKQLTGAQIRQMFLDFFQEKGHAVEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQNPRITNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTIHPEDEEAFTIWNEKMGVPKERIIRLEENFWDIGEGPSGPNTEIFYDRGEAYGNDFSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQDVPTNFDTDLFMPMIGATETISGEKYRNGDLEKDMAFKVIADHIRTVTFAVGDGALPSNEGRGYVLRRLLRRAVRYSKKLNINRPFMFELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEERFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTYGFPIELTEEYAEEAGMTVDQEGFENEMEKQRERARAARQDVDSMQVQGGVLGEVKVASEFVGYGTVATESNVVALVKNGEYTDSLQAGEEGQLMLNVTPFYAESGGQIADRGYLLADGVKVLVKDVQKAPNGQNLHKVVVEEGTLTKDAAVKAIIDTKNRGSVVKNHTATHLLHQALKDVLGTHVNQAGSLVTSERLRFDFSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAKEMGAMALFGEKYGDVVRVVQVGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKSAYELMNDQVGLLKEAAGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDSVMTVDGVNVLAAKVNVADMNNLRTMMDDLKNKLESAVVVLASVNDDKVNILAGVTKDLISQGYHAGKLVKEVASRCGGGGGGRPDMAQAGGKNPAQVEEALAFVQEYVKSVSK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y518_METTH
Sequence: MVCMRFRYICHRKPERTFSFRGHYFPVCSRCTGIYLGAFTYFLYAFLIPVKYTAATVLLALLLVIPTFIDGFTQLMGYRESNNVLRFSTGLPAGIGLAVLTKVLKHLILHI
What are the official names of this protein?
Uncharacterized protein MTH_518.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHOB_BOVIN
Sequence: MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
What is the function of this protein?
Mediates apoptosis in neoplastically transformed cells after DNA damage.  Not essential for development but affects cell adhesion and growth factor signaling in transformed cells.  Plays a negative role in tumorigenesis as deletion causes tumor formation.  Involved in intracellular protein trafficking of a number of proteins.  Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.  Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.  Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.  Required for genotoxic stress-induced cell death in breast cancer cells (By similarity).
What are the official names of this protein?
Rho-related GTP-binding protein RhoB.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Late endosome membrane; Lipid- anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity).
Protein: PROH1_APIME
Sequence: MSSLRIAMFLLVVLMVLIDCSTAIPAADKERLLNEVDLVDDDGSIETALINYLFTKQIVKRLRNQLDIGDLQRKRSYWKQCAFNAVSCFGK
What are the official names of this protein?
Prohormone-1.
What are the subcellular locations of this protein?
Secreted.
Protein: PYDC1_HUMAN
Sequence: MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVVAVLRDMRMLEEAARLQRAA
What is the function of this protein?
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation.  Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
What are the official names of this protein?
Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, cellular POP1, cPOP1.
What are the subcellular locations of this protein?
Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm.
Protein: RS15_SERP5
Sequence: MSLSVEAKAKIVADFGRGTNDSGSSEVQVALLTAQINHLQGHFSEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: H12_MOUSE
Sequence: MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK
What is the function of this protein?
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.  Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers.  Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
What are the official names of this protein?
Histone H1.2, H1 VAR.1, H1c.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
Protein: SYD_SALEP
Sequence: MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRARDAKNVNADMATGEIEVLASSLTIINRADSLPLDANHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELVDVADLLKSVEFAVFAGPANDPKGRVAALRVPGGAQLSRKQIDDYGNFVKIYGAKGLAYIKVNERAKGLDGINSPVAKFLTADIVDAILERTGAQDGDMIFFGADNKKVVADALGALRLKLGKDLSLTDEDKWAPLWVIDFPMFEDDGEGGLTAMHHPFTAPRDMTASELKTAPEEAVANAYDMVINGYEVGGGSVRIHNGEMQQTVFGILGINEQEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANQAALTELGIQVVKKAENN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_HYPNA
Sequence: MSKIIGIDLGTTNSCVAVMEGGQAKVIENAEGARTTPSVVAFTENGDRLIGQPARRQGVTNPDFTFYAIKRLIGRTFDDPTAQKDKAMSPFSIVKAPNGDAWVKGRDKDYSPQEISAFILTKMKETAEAYLGSKVTQAVITVPAYFNDAQRQATKDAGRIAGLEVLRIINEPTAAALAYGLDKGGNKTIAVYDLGGGTFDVSLLEIGDGVFEVLSTNGDTFLGGEDFDLRVVDFLASEFKKEQGIDLKGDKLALQRLKEEAEKAKKELSSATQYEVNLPFITADATGPKHLNIKLTRAKFESLVEDLVKRTIDPCQKALKDAGKTPAQIDEVVLVGGMTRMPAVQEAVKKFFNREPHKGVNPDEVVAIGAAIQGGVLQGDVKDVVLLDVTPLSLGIETLGGIFTRLIERNTTIPTKKSQVFSTAEDNQPAVTIKVAQGEREMASDNKQLGQFNLEGIAPAPRGLPQIEVTFDIDANGIVSVSAKDKATGKEQQITIQADGGLSEADIKNMMADAESNASTDKARRELVEAKNHAEALIHQTEKQLIEHGAKVTDAIKGDIEKAIADLKEAAAGDNAADIAAKHQALMNAAMKLGEAIYAAQGADAGEGEDAPQSGNDDVVDADFEEVDERK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RLMH_RHOPT
Sequence: MRLLILAVGKLKQGPERELAERYRARFDDLGRKLGFRGLDVHEIAESRAREAPARMAEEAAAIIAQVQDGAVLVTLDERGQSLGSTAFAAQLGRWRDEQVPGTIFVIGGADGLLPELRRKAKLSMSFGGATWPHQMVRVMLLEQIYRAATILAGHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_PASMU
Sequence: MADNIIIFDTTLRDGEQALKASLTVKEKLQIAFALERLGVDVMEVGFPISSAGDFESVQTIARHIKHSRVCALSRAVDKDIDAAAEALKVAEAFRIHTFIATSALHVEAKLRRTFEDVVDMAINAVKRARNYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGYCLPYQYGDIIANVMNRVPNIDKAIISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDMFNGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKHKNTYEIMSPESIGLKKEKLNLTARSGRAAVKNHMSEMGYQESDYDLDKLYEAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLTLDVITSQCISHLPASAFVQVELDGKKMSQVSNGGNGPVDAVYNAILAITGLEMKMLNYNLTAKGEGAEALGQVDIVVEHEGRRFHGVGLATDIVESSARALIHAINAIYRSQKVADLKLHKIAGV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.