PharMolix/UniProtQA huggingface dataset:
Protein: TDH_SALEP
Sequence: MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIP_NEIGO
Sequence: MYEIKQPFHSGYLQVSEIHQIYWEESGNPDGVPVIFLHGGPGAGASPECRGFFNPDVFRIVIIDQRGCGRSHPYACAEDNTTWDLVADIEKVREMLGIGKWLVFGGSWGSTLSLAYAQTHPERVKGLVLRGIFLCRPSETAWLNEAGGVSRIYPEQWQKFVAPIAENRRNRLIEAYHGLLFHQDEEVCLSAAKAWADWESYLIRFEPEGVDEDAYASLAIARLENHYFVNGGWLQGDKAILNNIGKIRHIPTVIVQGRYDLCTPMQSAWELSKAFPEAELRVVQAGHCAFDPPLADALVQAVEDILPRLL
What is the function of this protein?
Hydrolyzes peptides having the structure Pro-Y-Z to yield free proline.  Also hydrolyzes the dipeptide Pro-Gly.
What are the official names of this protein?
Proline iminopeptidase, PIP, Prolyl aminopeptidase, PAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCSQ_ECOLI
Sequence: MAVLGLQGVRGGVGTTTITAALAWSLQMLGENVLVVDACPDNLLRLSFNVDFTHRQGWARAMLDGQDWRDAGLRYTSQLDLLPFGQLSIEEQENPQHWQTRLSDICSGLQQLKASGRYQWILIDLPRDASQITHQLLSLCDHSLAIVNVDANCHIRLHQQALPDGAHILINDFRIGSQVQDDIYQLWLQSQRRLLPMLIHRDEAMAECLAAKQPVGEYRSDALAAEEILTLANWCLLNYSGLKTPVGSAS
What is the function of this protein?
Essential for cellulose biosynthesis, shown for strain 1094, a commensal, natural cellulose producer (PubMed:19400787).  Also shown in strain W3110 which has a restored reading frame (TAG stop codon to TTG for amino acid 6, called strain AR3110), this protein (PubMed:24097954).  May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole (PubMed:19400787).  The combination of cellulose and the curli fiber network confer cohesion, elasticity and tissue-like properties to colonies (PubMed:24097954).
What are the official names of this protein?
Cellulose biosynthesis protein BcsQ.
What is the protein family that this protein belongs to?
Belongs to the BcsQ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at the cell pole, this does not require any genes of the divergently expressed yhjRbcsQABZC and bcsEFG operons.
Protein: VP5_IBDVU
Sequence: MLSLMVSRDQTNDRSDDKPARSNPTDCSVHTEPSDANNRTGVHSGRHPREAHSQVRDLDLQFDCGGHRVRANCLFPWLPWLNCGCSLHTAEQWELQVRSDAPDCPEPTGQLQLLQASESESHSEVKHTPWWRLCTKWHHKRRDLPRKPE
What is the function of this protein?
Plays a role in the release of virion progenies by disrupting the host plasma membrane.
What are the official names of this protein?
Protein VP5.
What is the protein family that this protein belongs to?
Belongs to the avibirnavirus/aquabirnavirus VP5 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: T22D1_RAT
Sequence: MKSQWCRPVAMDLGVYQLRHFSISFLSSLLGTENASVRLDNSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGSTA
What is the function of this protein?
Transcriptional repressor (By similarity).  Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).
What are the official names of this protein?
TSC22 domain family protein 1, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein.
What is the protein family that this protein belongs to?
Belongs to the TSC-22/Dip/Bun family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DPH1_DANRE
Sequence: MAASSSELEVITAKKPNVKGPRRVANQIPEEILKDSDLNEAIKALPANYNFEIHKTIWRVRQAKAKRVALQLPEGLQMFACVIADIIERFTEADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTEGIKMLYVFVDIQIDTAHFLDTLRFNFPPGRSLALVSTIQFVAALQAASAALKPDYEVLVPQCRPLSPGEILGCTSPRLDKHVNAVIYLGDGRFHLESIMIANPDTPAYRYDPYSKVFSREYYDHDAMRATRLKAIESACSAQRWGLILGTLGRQGNPKILEHLESQLKSLGRSFTRVLLSEIFPRKLELLADVDAQQWRYSRLDGRMCIPWISIPIRVWGPGLLIIRITNLNGLHAKPHRRLVSR
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HSD4B_ARATH
Sequence: MDLNNKIFNILLPIVTVSFLLVFMPFSIFFKLLQFIRGCKESEKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYATHFAIPHLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHPEVGVTIVFPGLIENGNTNPDLLAEKQDWSQVVTIESAAECAKAVVNGICRGKTFVAEPSWVRVLFWLSAICPELLISKPKRN
What are the official names of this protein?
11-beta-hydroxysteroid dehydrogenase-like 4B, 17-beta-hydroxysteroid dehydrogenase-like 4B, Hydroxysteroid dehydrogenase 7, AtHSD7.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: PIPS_MYCMM
Sequence: MSKAPFLSRAAFARVTNPLARGLLRIGLTPDAVTIIGTTASVAGALVLFPMGKLFPGACVVWFFVLFDMLDGAMARERGGGTRFGAVLDAACDRISDGAVFGGLLWWVAFGMRDRLLVVATLICLVTSQVISYIKARAEASGLRGDGGIIERPERLIIVLAGAGVSDFPFIAWPPALPVAMWLLAVTSVITCGQRLYTVWTSPGATDLLVPSAPVRDDDAQGHPRSGDPGKTQR
What is the function of this protein?
Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP.  PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall.
What are the official names of this protein?
Phosphatidylinositol phosphate synthase, PIP synthase, CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IGF1_CANLF
Sequence: MGKISSLPTQLFKCCFCDFLKVKMHTVSSSHLFYLALCLLTFPSPATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNASRGSAGNKNYRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.  Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.  May play a role in synapse maturation.  Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.  Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UTP25_ARTBC
Sequence: MAIQHKKGGGHRGRGSKTGRSRGRKFETSRLKDVREDESSGEEEDVDVQPAEDMNDSEGTDVSSESGLDEPPKENSYSTLLKLLNTDAKSNEPARKKRKIKANEPDANLVEVSIPTADDIEQMDEVADTEASASEDENMDDEGLPGEDYAEDIGTDGRNDMFELHFGNPDETELSQKIQACSKAWKSTKADLIDGLYSVVSMPDVEGNSSAIPEACWSVRLLTYRQLKQKLARNTVSFDRLNSCLTPYIFGYHDTFFCSRTTQNSAKLRDLYCLHALNHVLKTRDRVIKNSAILSREDNGDVELRDQGFTRPKVLIILPTRQACVRVINSFTKIYPMEQQENKKRFMDSFSAADSDEWAHKPDDFKELFGGNDDDMFRLGLKFTRKSLKFFSKFYSSDIILASPLGLRTAIEKEGGKKNENDFLSSIEMVIVDHADALIMQNWDHVEYIFSNLNLQPKEAHGCDFSRVRQWYLDGHGKFLRQTLVFSAFNTPELNALYNTQMQNVFGKAKIMSKYEGAMLNLRLPISVKQTFSRFDSASPLKDPEARFQYFTRTVLASLARGWTESSSRKKSGGTLIFIPSYLDFVRVRNHFANSSQTENISFGLISEYTSVRDSSRARSHFMNGRHSVLLYTERAHHFRRYNIRGVTNIVMYGLPDNPIFWGDLIEYLGSAAGGTATPTVRVLFSKWDALKLERIAGTARVRSMLLEKGGDTFTFV
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PELO_METTH
Sequence: MRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIRSDRGVKKTFYLGIRVETVSFHIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQKEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIRQYGVEYRGPITGHIPGKRIQQRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENTGTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINMGAVEKLLVLDRVVSREDIEGYLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOM1A_MISBR
Sequence: SPVCTPSGQPCQPNTQPCCNNAEEEQTINCNGNTVYRCA
What is the function of this protein?
Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-actinopoditoxin-Mb1a, Omega-AOTX-Mb1a, Omega-missulenatoxin-Mb1a, Omega-MSTX-Mb1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 02 (omega/kappa toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPLA_ECO27
Sequence: MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALDVSAEASGRNDLVVKTAEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPEITHEQVCEAITEAFFAHYGERVEAEIISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSTWIAGAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCPH_TETTH
Sequence: NDGATILNLLDIVHPAAKTLVDIAKAQDDEVGDGTTSVCLLAGELLKESKYFIEEGMHPQIITKGYKEALKLALQFLHENAHSVADKNETEKREMLIKCAQTSLNSKLLAHYKEFFSELVVQAVETLETNLLDKDLIGIKMVTGGSVTDSFLVSGVAFKKTFSYAGFEQQPKKFNNPKICLLNIELELKAEKENAEIRIENPDDYKSIVDAEWELIYEKLRKIVESGANIVLSKLPIGDLATQYFADRNIFCAGRVDAEDMKRVQKSTGAIVQTTVNGLTEDVLGTCNQFEEVQIGAERYNLFKDCPHSKSATIILRGGAEQFIAEAERSLNDAIMIVRRCMKANKIVPGGGA
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit eta, TCP-1-eta, CCT-eta.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB3_VIBCH
Sequence: MKILVVDDSALMRTTISDILQNIPNAEIKTARDGMDAIDKVMKWQPDVMTLDINMPNMDGLTCLTQIMVERPLPIVMLSSLTHEGAITTLEALYLGAVDFVAKPGGTICGRLQEVAPLIREKVRAAAKMRVKVHTQLSVSPAEVEHKHKSPVVENNEDHQLAIMGVSTGGPGTVETILRHLPADFSLPIIVNQHMPESFTAAFAQRLNRHLQQPVKEINRALVLEAGTVYVCKGDRDCIVTLRDGKLAAMPTPNDSHFSWHPSVSKLVASAIRTCGEDNLLCVMLTGMGDDGATEMAQVAQGNGIVFAQEPTTCVVPSMPEALLKRVPHIPTGTPEHLAYLMTEVVRQSSRELHYGNH
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 3.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIE2_DANRE
Sequence: MCLLDSCTALLLLGCWMSGSAVRISDVTLVNPDPVVSPLTAPSLLCVSSDWSSGGSVLALGQEFPRPQGSVLALGQEFPHTEPRPHPAAATVTWSSRSHAFGAFYCQIRNSTGRKIYTYKMLQEAAFLPESLTITVNQGENINISYSRRLYSPEDTVIHKNGHFEHSSPKEDISDIIHYPVTNAKAESHAGIYAIRYISAAPSSAAITRLIVRSCRAGFWGPNCTESCPRCANGGVCDDTTGECVCPPGFRGHTCDIVCGEGRFGAGCKERCVDGVCRALVFCLRDPYGCSCASGWRGLSCNDACPDGYYGAGCTQKCVCAKGRCDRFRGCVCAGRHGSRCEEADSSPVISHLRDVEINTGVELSVNCSASGRPAPLHGDITLITANRTTIAAVDTHTLNDQSTSVFRVQQVRVSSAGRWRCQVNNTHMQVEDEFTVEVKVPPRPQNPPVLQGSGPRHLLLLLNTEPYSGDGPIATTTLLYRPASAHTWSSVTAHGPLVRLDNLYPMTQYLTQVQLSRPGPGGAGQAGPAATFSTQVLELPVGVKLSAVSQTALLLSWDIAPAEQHCTYEVSCLQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSASAWTLSDQLPPPPANISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVEQAQYRQQVELPVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEPAVHFSSAPPPHRRSAVVSRSLVFPALQWSDIQFQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRMLEERKTYVNTTLYEKFTYAGIDCSAEEAG
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.  Can activate or inhibit angiogenesis, depending on the context.  Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase receptor Tie-2, Tyrosine kinase with Ig and EGF homology domains-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell (By similarity).
Protein: KRT_CEREL
Sequence: YSSQLAQVQGLIGNVESQLAEIR
What are the official names of this protein?
Keratin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: NHAA_RHOSO
Sequence: MNNIIPTQEEIAARVKALESILIEQNVISTAMVDRMVEIYEEEVGPKLGAKVVAKAWTDSEFKARLLDDATEACKELGISGLQGEDMVVLEDTDDVHHAIVCTLCSCYPWPVLGLPPNWYKEPAYRARIVREPRTVLSEEFNYHLPESTEIRIWDTSSEMRYWVLPQRPEGTEGWSEEQLAELVTRDSMIGVGPVKTPA
What is the function of this protein?
NHase catalyzes the hydration of various nitrile compounds to the corresponding amides.  Industrial production of acrylamide is now being developed using some of the enzymes of this class.
What are the official names of this protein?
Nitrile hydratase subunit alpha, NHase, Nitrilase.
What is the protein family that this protein belongs to?
Belongs to the nitrile hydratase subunit alpha family.
Protein: ANTR_LITCT
Sequence: MDKKVCVSILLAMLAIAALCRPMTELESARHGAQRKNSISDVSRRDLLASLTHEQKQLIMSQLLPELLSELSNAEDHLHPMRDRDYAGWMDFGRRSSEVTES
What is the function of this protein?
May control digestion processes.
What are the official names of this protein?
Gastrin/cholecystokinin-like peptide, Antral peptide.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEY1_MAGO7
Sequence: MNGNFAAVGSEPTDAQFEHGIQVIDEDKQYNGLVNDYLRRTHVAEAGFNYHLISVFGSQSTGKSTLLNNLFGTEFSVMSESERRQTTKGIWMSKNKREGKMAENILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDKQSSPRSLLFFVIRDHIGNTPLSNLRNTLVQDLTKIWSSISKPPALENAKIEDYFDFAFAALPHKILQPEKFVTEVENLGTRFVAGHRSTQDQEFVGGVFLPEYHRRIPADGFSIYAEGIWDQIVNNKDLDLPTQQELLAQFRCDEISRDVLNAFDEAITPLEDKQAEASRLGKPFVLPDLGDTARSARSKAVEAFKVQASRYHKGVYTRKQAELEGKMDSRLKALYQGQLAAAHKAGVAAFSDAVTGAVKAGQKSGGSYEFAEIVDKQKRKTLDIFAKEAQGLEIEGLAWTNFKPQFLLFEKELDEVSARLRKDEMRRLATRVERWVKSRLGDSIGLEFNKLGSGRGGSGAPETGEKPATEKDLWDRIWTVFVAVVKEAQERFAERAKSFEASSEEVEIGLWRLRRKSWVALRERIDEEVMEGNILLKLRENFEDKFRYDEAGVPRIWRPTDDIEGIYTRARESTLTLIPLLSRFRLAETYASPDLPGWIGNQPPGVEPDDEEDLTPIGGIDEEEGKSLEEEMTVLSESKRQDLVVRFKKTADGVYVEAKRGALGGMTQVPLYFWIALFAFGWNEIWMVIRNPFLFILLLLSAGGTYVAYNLSLLGPMMQMTNAAANQASEIGKQKLREFLENNETARQALAMPASSKSSGGEQVRMDTLDSKGKKKDYDDDGI
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: LRGA_BACC2
Sequence: MSTKKVYSFLSQAFIFSAIMLISNIIATHLPIPMPSSVIGLVILFSLLCLKVIKLEQVESLGTALTGIIGFLFVPSGISVINSLGVMGQYFVQILTVIVVATVILLAVTGLFAQFILGKDEKETEDTKELKVVNKGRKHGKVA
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA.  The LrgAB and CidA proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ING5_DROME
Sequence: MSSAIYLENYLDGLESLPTELERNFKLMRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMSEDERRERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEKASSTRAKSEEVVAKKGRKKTKDSKTTGKKKKSASSDEETGRGNNQSNANSSVNSSSNAGQGSKKKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVGLTTKPKGKWFCPKCTQDRKKK
What is the function of this protein?
Component of the Enok complex which has a histone H3 acetyltransferase activity.
What are the official names of this protein?
Inhibitor of growth protein 5, Inhibitor of growth family member 5.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL23_METM7
Sequence: MDAFDVIKTPIVSEKTMKLIEEENRLVFYVERKATKADIRAAIKELFDAEVADINTSITPKGKKKAYITLKSEYNAGEVAASLGIY
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CCME_BRUO2
Sequence: MSATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRTPADLTEQDMTSGARFRLGGLVEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQGVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKGVWEGK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RECR_TOLAT
Sequence: MKFSPLLDALIRELQVLPGVGPKSAQRMAFQLLERERKRGMQLGQTLQRALTEIGHCQHCRTFTENSLCDICANPKRAESGQLCIVETPADVAAIEQTHLYSGRYFVLMGHLSPLDGIGPKELGLDQLDNVLQGGQWKEVILATNPTIEGDATAFYIASMAKRYQINITRIAHGVPVGGELELVDGTTLSHSLSGRRPLE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ERA_MYCBT
Sequence: MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
What is the function of this protein?
Exhibits GTPase activity.  Binds RNA but is probably not involved in ribosome assembly in mycobacteria.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.