PharMolix/UniProtQA huggingface dataset:
Protein: NHAP2_ECOLI
Sequence: MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLTTALEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALGKLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAES
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity).  Participates in control of cell volume in low-osmolarity conditions.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYNS_ECO7I
Sequence: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDAILLLQMIPLRGCIDDRIPTDPTMYRFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RS9_PSEF5
Sequence: MSATQNYGTGRRKTATARVFLRPGTGNISINNRSLDNFFGRETARMVVRQPLELTETVEKFDIYVTVIGGGVSGQAGAIRHGITRALMDYDETLRSALRKAGFVTRDAREVERKKVGLRKARKRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MAP22_EMENI
Sequence: MGSKTPERDGHKGQENTTGPVECPLGGMPRGMHLATDGDGTIGDSGDDDDGEAHSTALINANANGNQKKKRKSKKKGKKKAAKQSSPPRVPLSQLFLQGKYPIGEVQEYQPNVENTSRTTAEEVRYKSRSHLEDDSFLNDYRKAAEVHRQVRKWTQERVKPGQGLMEIAEDIDDGVRALLGHAGLEPGDSLKAGLGFPTGLSLNNVVAHYTPNPGQKDIILQSSDVMKVDFGVHINGWIVDSAFTMTFDPVYDNLLAAVKDATNAGLKTAGIDVRISDVSAAIQEAMESYEVEIGGKTFPVKAVRNITGHNIKHYQIHGGKSVPFVKNSDQTKMEEGEIFAIETFGSTGRGYIYDDVGVYGYGKSYDAPRQVSLPLASARSLYKTINENFGTIVFCRRYLDRLGLQRYLAGMNTLVQHGVVDVYAPLVDIKGSYSAQFEHTVLLRESNKEVISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_THEMA
Sequence: MRIKKGDLVEVISGKDKGKRGKVLRVIPKENKVIVENVNMVKRHQRPVPQLREGGIIEREAPIYASKVMVVCPACDKRTRVGYRFTEDGKKVRYCKKCGEIIDKD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: TUS_SALPA
Sequence: MSRYDLVERLNGTFRQIEQHLAALTDNLQQHSLLIARIFSLPQVTKEAEHAPLDTIEVTQHLGKEAEALALRHYRHLFIQQQSENRSSKAAVRLPGVLCYQVDNATQLDLENQIQRINQLKTTFEQMVTVESGLPSAARFEWVHRHLPGLITLNAYRTLTLINNPATIRFGWANKHIIKNLSRDEVLSQLKKSLASPRSVPPWTREQWQFKLEREYQDIAALPQQARLKIKRPVKVQPIARIWYKGQQKQVQHACPTPIIALINTDNGAGVPDIGGLENYDADNIQHRFKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDZ1P_HUMAN
Sequence: MNGGVQTWTQPRLCYLVKEGGSHGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGWGRVGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEEDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESKHDSHMAKERAHSTASHSSSNSEDTEM
What are the official names of this protein?
Putative PDZ domain-containing protein PDZK1P1, PDZ domain-containing 1 pseudogene 1, PDZ domain-containing 1 pseudogene 2.
What is the protein family that this protein belongs to?
Belongs to the NHER family.
Protein: COAD_GEODF
Sequence: MPLKIAVYPGSFDPITYGHLDIIERGLRIFDKIIVAVAKNSEKNSLFPTDERIALIKEVLGDSERAEVDTFTGLLVDYVRDQGATVIIRGLRAVSDFEYEFQLAQMNRSITQDIETLFMMTSVPYSYLSSSIVKEVSSLNGPIEGLVPPAVKKALDAKFNR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI3F1_DROVI
Sequence: MSALNLTVRVHPVVLFQVVDAFERRNADSHRVIGTLLGSVDKGVVEVTNCFCVPHKEHDDQVEAELSYALDMYDLNRKVNANESVVGWWATGNEVTNHSSVIHEYYARECNNPVHLTVDTSLQGGRMGLRAYVCIQLGVPGGKTGCMFTPIPVELTSYEPETFGLKLLQKTVGVSPAHRPKTVPPMLDLAQISEASTKLQSLLELILKYVDDVIAHKVTPDNAVGRQLLDLIHSVPHMTHEQFTQMFNANVRDLLMVITLSQLIKTQLQLNEKLTFLPTA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F-1, eIF3f-1, Eukaryotic translation initiation factor 3 subunit 5-1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_AERHY
Sequence: MQTYLVGGAVRDRLLGLPQGDRDHLVVGATVEQMLALGFTQVGRDFPVFLHPKTQQEYALARTERKQGRGYTGFVCHASPEVTLEQDLLRRDLTVNAIAEDEEGRLHDPYGGIQDLERRVLRHVSPAFAEDPLRILRVARFAARFHAQGFVVAPETLALMREMTDAGELAHLTPERVWKELERVLLGETPQI
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate (By similarity).
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.
Protein: SKP2B_ARATH
Sequence: MVSEGATRKELNLCFENMKMEGVLISEWKDIPVELLMKILNLVDDRTVIIASCICSGWRDAVSLGLTRLSLSWCKKNMNSLVLSLAPKFVKLQTLVLRQDKPQLEDNAVEAIANHCHELQDLDLSKSSKITDHSLYSLARGCTNLTKLNLSGCTSFSDTALAHLTRFCRKLKILNLCGCVEAVSDNTLQAIGENCNQLQSLNLGWCENISDDGVMSLAYGCPDLRTLDLCSCVLITDESVVALANRCIHLRSLGLYYCRNITDRAMYSLAQSGVKNKHEMWRAVKKGKFDEEGLRSLNISQCTYLTPSAVQAVCDTFPALHTCSGRHSLVMSGCLNLQSVHCACILQAHRTHTVYPHPAH
What is the function of this protein?
Component of SCF(SKP2B) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of the cyclin-dependent kinase inhibitor KRP1.  Does not interact with auxin.
What are the official names of this protein?
F-box protein SKP2B, F-box/LRR-repeat protein 5, AtFB5, SKP2-like protein 2, AtSKP2;2.
Protein: FRE21_SPHLA
Sequence: MAFLKKSLFLVLFLGLVSLSMGEREKREEEEEEEEENKEEEANEEGKGESEEKRGLVGTLLGHIGKAILGG
What is the function of this protein?
Antimicrobial peptide with potent activity against some Gram-positive and Gram-negative bacteria (PubMed:30044391).  Has a multifunctional mode of action (PubMed:30044391).  It displays depolarization and bacterial cell leakage, and can also internalize into bacterial cells and alter specific gene expression involved in bacterial resistance mechanisms (PubMed:30044391).  Does not agglutinate bacteria and lipid vesicles, even a high concentrations (PubMed:30044391).  Also displays moderate cellular protection against yellow fever virus (YFV)-infected Vero cells without causing significant cytotoxicity (PubMed:27049440).  Shows a weak hemolytic activity, and is not cytotoxic to monocytes (PubMed:30044391).  Frenatin 2. 3S (version without Gly-71) shows no or very weak antibacterial activity, shows no or very weak cytotoxicity to lung adenocarcinoma A549 cells and shows very weak hemolysis (PubMed:24704757).  It only stimulates production of pro-inflammatory cytokines IL-23 (but not IL-1beta and TNF-alpha) by mouse peritoneal macrophages and has no effect on the production of the anti-inflammatory cytokine IL-10 (PubMed:24704757).  Frenatin 2. 3S (version without Gly-71) very weakly stimulates insulin release (PubMed:30244134).
What are the official names of this protein?
Frenatin 2.3S, F2.3S.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Frenatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYH_LACP3
Sequence: MNYQRPKGTADILPGQSERWQQVEAVARKIFAQYQYHEIRTPIFENVDVFSRSAGDTSDIVTKEMYTFKDKGDRMMALRPEGTAGVVRAYVENKLYGPEHAKPYKVYYLGPMFRYERPQSGRQRQFHQIGVEAFGSDSPVLDAETLALAKQLLEALGAKHLKFVINSLGDPATRKAFHAALVDYLTPFKDQLSEDSKVRLVKNPLRILDSKDKHDQEIVANAPSILDYLTPEAQQHFDRVKTLLQGLGIPFEVDATMVRGLDYYNHTIFEVMSDDKVFGGGYTTILAGGRYNGLVEELGGPETPGIGFAMGVERLMLLMQGELPTAQPDAYIVTIDQGADQEALQMLTAIRQQGFTGEMDYMGRKPKGQFKAANKANAKLVLTIGESERAAGTVQIKNMATGDQQAFPQADVLADFGKIYTQVMEAK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_NITEU
Sequence: MQTQGEASNPLERNIELSVSREKVEAEVGVRLKRLAPKVKVQGFRPGKVPLKIVAQQYGHQVEHEVLGELLQQQFNDAVNQENYRVAGIPGFESRNSDANGATSYEFRATFEIYPDIELGDLSSITVNKPVLQIGDAEIQKTLDILRKQRATYEPTDRPAQTGDRVTIDYRGVLDGEGFPGGQADDYSVILGNGHLLEDFESSILGMTAGQEKTFDMTFPADYPGKDVAGKKVSFTIRLNKLEAPKLPEVDGEFAKSLGVAEGDIDKMRSEIKANLQREISQRIRTKLKEQVMQSLLDKVLIQVPKVLIRQEADRLAEEMQNSRAARGFRKDQSLSGDVFLEKAERRVRLGLILSKLIDTHELSVKPEQVRSFIEEYAQGYENPEQVIKWHYASPERLKEIEPLILEDNAVSWLLDKAKIIDQSVTFDELMGYSHATNV
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PSTB_STAAN
Sequence: MAQTLAQTKQISQSHTFDVSQSHHKTPDDTNSHSVIYSTQNLDLWYGENHALQNINLDIYENQITAIIGPSGCGKSTYIKTLNRMVELVPSVKTAGKILYRDQDIFDQKYSKEQLRTNVGMVFQQPNPFPKSIYDNITYGPKIHGIKNKKVLDEIVEKSLRGAAIWDELKDRLHTNAYSLSGGQQQRVCIARCLAIEPEVILMDEPTSALDPISTLRVEELVQELKEKYTIIMVTHNMQQAARVSDKTAFFLNGYVNEYDDTDKIFSNPSNKKTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL29_VIBVY
Sequence: MKAQDLREKSVEELNSELLNLLREQFNLRMQAATGQLQQTHTLKAVRRDIARVKTVLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ATPB_OENBI
Sequence: MRINPTTSGPGVSTLEKKKSGRIAQIIGPVLDVTFPPGKMPNIYNALVVKGRDTGGQEINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDELGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKAGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGDEHYETAQRVKETLQRYKELQDIISILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGTIDEATAKAANLEMESDLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ISK13_RAT
Sequence: MTRRGCWPHRIIFSLILLTWTHVTLAALIRSHTFSNWPKPPCKMYYPIDPDYEANCPDVIALVCATNGLNYKNECFFCIDRWEFGPHIEFVKYGKCE
What is the function of this protein?
May be a serine protease inhibitor (By similarity).  Essential for sperm maturation and fertility.  Inhibits sperm acrosome reaction, protecting sperm from premature reaction.
What are the official names of this protein?
Serine protease inhibitor Kazal-type 13.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit.
Protein: RS20_STRPG
Sequence: MANIKSAIKRAELNVKANEKNSAQKSAMRTAIKAFEANPSEELFRAASSSIDKAESKGLIHKNKASRDKARLAAKLG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: COXX2_PYRAE
Sequence: MSPYISLLKPRVIWLLILASVAGYIYGGGGVDSRLFSLLAVAFLSTGGSAAFNHYWERDIDALMTRTFKRPLPSGLITPNAALAYSLALSATGISLGFLLLGLLPGLFVLLGWLFYAVVYTIVLKRRTWLNIFGGGFAGNAVFLGGYALAKGTVDLPAVLISFAIYLWTPSHIWALAFKYRGDYKRAGVPMLPALIKEERAVAVISAINAAAAAYILWLYLQFGGGAGGAIVALGVAATIATSIYAAVKKTEEAMWKMYKASSPMLTLFLIALMIQRYRL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 2, Heme B farnesyltransferase 2, Heme O synthase 2.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7S_SALPC
Sequence: MPKKNEAPASFETALSELEHIVTRLESGDLPLEDALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEEASPEPFIADNE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I76A1
Sequence: MNPNQKIICISATGMTLSVVSQLIGLANLGLNIGLHFKVGETPEIGTPSVNETNSTTTIINYNTQNNFTNVTNIVLIKEEDEMFTNLSKPLCEVNSWHILSRT
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane (By similarity).
Protein: TBC23_XENLA
Sequence: MCREADLSEALEAGGCDLETVRNIIQGRPVPCDLRTKVWKIALNVSGKGDSLASWDGSLDLQEQPLIHRDCQNLIDRLSVAEERKTALLEDIESVVTFYCKSRNVKYQEDASWIHLLNPLVGLQLPRSDLYNCFYAIMNKYIPRDCNRKGKPFHLFRLLLQYHEPELCSFLDTKKITPDLYALNWFGSLFAFHCSVEVTQAIWDNYLQQADPFFMYFLMLIMLVNSKETVLGQDMDDKEELIKCLENTPSSLEVEDIEDLFSLAQYYYSKTPASFRKDHQSLFGSSLIAFKDDTDLSQALCLAVSVSEILQANQQQGDGVRFFVVDCRPAEQYNSGHLSTAFHLDSDLMLQNPGEFALSVKSLLEAQKQSIESGSIAGGEHLCFMGSGRDEEDMYINMVLAHFLQKNKEYISIAKGGFMALQQHLADFNMENGYGHWIVSTSGSHSSISMYADGDSAVAADDGKGMKSLVNKMTVAFKTKSVNVKDKVISFIENTATPVDRITFNIPWPERASLERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEVDSSSMSDDDRKEIVNVQTWINKPDVKHHFPCDEVKDNGHRFPSHLLVTATHMYCLREILSKKGFAYIQSRQALSTVVKITSKKKHPELITFKYGSSNASGVEISAVERYLIPNAGDATKAIKQQIMKVLDALES
What is the function of this protein?
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking.  Involved in endosome-to-Golgi trafficking.  Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity).  Plays a role in brain development (By similarity).  May act as a general inhibitor of innate immunity signaling (By similarity).
What are the official names of this protein?
TBC1 domain family member 23.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle.
Protein: PSD_NEIGO
Sequence: MNRLYPHPIIAREGWPIIGGGLALSLLVSMCCGWWSLPFWVFTVFALQFFRDPAREIPQNPEAVLSPVDGRIVVVERARDPYRDVDALKISIFMNVFNVHSQKSPADCTVTKVVYNKGKFVNADLDKASTENERNAVLATTASGREITFVQVAGLVARRILCYTQAGAKLSRGERYGFIRFGSRVDMYLPVDAQAQVAIGDKVTGVKTVLARLPLTDSQADPVSQAASVETAANPSAEQQQIEAAAAKIQAAVQDVLKD
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ARGR_ANADE
Sequence: MTSADRRRDAVARIIRARRIGTQEELLAALERAGFRATQATLSRDLARLGARRVSGPEGAVYELGADGADGADGGLAALRGLVSSIAANASMVVIRTHPGSAPAIARAIDLAQPPEVLGTIAGDDTIFVAPAGELRPRRLAARLAELLGTPSALAGEGGDRTH
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YB043_HUMAN
Sequence: MRPLLCALAGLALLCAVGALADGREDRGSPGDTGERPAGPARGPGLEPARGTLQPRPRPPRKRWLLSPGAGAQQLEVVHLPGSTL
What are the official names of this protein?
Putative uncharacterized protein ENSP00000380674.
What are the subcellular locations of this protein?
Secreted.
Protein: IL31R_MOUSE
Sequence: MWTLALWAFSFLCKFSLAVLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTLSISVFEIVLLTSLVGGGLLLLSIKTVTFGLRKPNRLTPLCCPDVPNPAESSLATWLGDGFKKSNMKETGNSGDTEDVVLKPCPVPADLIDKLVVNFENFLEVVLTEEAGKGQASILGGEANEYVTSPSRPDGPPGKSFKEPSVLTEVASEDSHSTCSRMADEAYSELARQPSSSCQSPGLSPPREDQAQNPYLKNSVTTREFLVHENIPEHSKGEV
What is the function of this protein?
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5.  May function in skin immunity (PubMed:15184896).  Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353).  Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).
What are the official names of this protein?
Interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, GLM-R, mGLM-R, Gp130-like monocyte receptor, Gp130-like receptor, Novel cytokine receptor 10, NR10, ZcytoR17.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Presynaptic cell membrane. Cell projection, axon.