PharMolix/UniProtQA huggingface dataset:
Protein: THSA_BACCS
Sequence: MKMNPIVELFIKDFTKEVMEENAAIFAGAGLSMSVGYVSWAKLLEPIAQEIGLDVNKENDLVSLAQYYCNENQGNRGRINQIILDEFSRKVDLTENHKILARLPIHTYWTTNYDRLIEKALEEENKIADVKYTVKQLATTKVKRDAVVYKMHGDVEHPSEAVLIKDDYEKYSIKMDPYIKALSGDLVSKTFLFVGFSFTDPNLDYILSRVRSAYERDQRRHYCLIKKEERRPDELEADFEYRVRKQELFISDLSRFNIKTIVLNNYNEITEILQRIENNIKTKTVFLSGSAVEYNHWETEHAEQFIHQLSKELIRKDFNIVSGFGLGVGSFVINGVLEELYMNQGTIDDDRLILRPFPQGKKGEEQWDKYRRDMITRTGVSIFLYGNKIDKGQVVKAKGVQSEFNISFEQNNYVVPVGATGYIAKDLWNKVNEEFETYYPGADARMKKLFGELNNEALSIEELINTIIEFVEILSN
What is the function of this protein?
NAD(+) hydrolyzing component (NADase) of the Thoeris antiviral defense system, composed of ThsA and ThsB.  Activated by a signal molecule generated by endogenous ThsB (AC J8G8J6) or ThsB' (AC J8CSK2, probably 3'cADPR), by TIR1 and TIR2 from B. dafuensis or by BdTIR from B. distachyon (AC I1GTC2, probably 2'cADPR).  Upon activation binds and hydrolyzes NAD(+), leading to cell death and inhibition of phage replication.  Not seen to bind DNA (PubMed:32499527, PubMed:34853457, PubMed:36174646).  Activation is 50-100x more sensitive to 3' cyclic ADP-D-ribose (3'cADPR) than 2'cADPR (PubMed:36174646).  In another paper ThsA is not activated by any tested cADPR isomer, although it binds 3'cADPR; it was suggested the protein is already in a fully active state (PubMed:36048923).  Expression of ThsA and ThsB in B. subtilis (strain BEST7003) confers resistance to phages phi29, SBSphiC, SBSphiJ and SPO1 (PubMed:29371424, PubMed:34853457).  At multiplicity of infection (MOI) of 0. 05 Thoeris-encoding cultures grow normally when infected with SPO1, at MOI 5 cultures collapse prematurely by 90 minutes post-infection, thus the phage are not able to complete a replication cycle.  NAD(+) levels fall and ADP-D-ribose levels rise 60 minutes post-infection.  Thoeris cultures eventually recover, but retain the same susceptibility to SPO1 (PubMed:34853457).
What are the official names of this protein?
NAD(+) hydrolase ThsA, BcThsA, NADase ThsA, Thoeris protein ThsA.
What is the protein family that this protein belongs to?
Belongs to the soluble Thoeris ThsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_PYRIL
Sequence: MAKIYTDKDASLEPLKGKTIAVIGYGIQGRAQALNLRDSGLKVIIGLRKGGNSWNLAVSEGFEVYEVSDAVAQADVIMVLIPDMEQPKVWQNQIAPFLKEGAVVDFAHGFNIHYGLIKPPKNVDVIMVAPKAPGKAVREEFLAGRGVPALVAVHQDYSGAALKYALAIAKGIGATRAGVIETTFAEETETDLIGEQIVLVGGLMELIKKGFEVLVEMGYQPEVAYFEVLNEAKLIMDLIWQRGIYGMLNGVSDTAKYGGLTVGPKIIDEEVKKKMRIFALRVKSGEFAKEWVEEYARGGLTLKKLMESARTHPIEIVGAEMRKLLFGRQQE
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RS4_METBU
Sequence: MAYPGKSTKSYDTPQHPWQAERMASEVELVKKYGLRNKRELWKSLSVLRRFRGDARRLLAESAESDLIGHSKTEADQLLTKLIRFSILKSDSNIDDVLGLQTEAILERRLQTQVHRLGLARTARQARQFITHGHIAIDGKRVTVPGMMVTREQEMNVEYYGTSPMTKESHPERPAQIAASVVEE
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: YG121_YEAST
Sequence: MSRHKYKLWMCIAKGKRGVGERNTFVPKCSYAPFCASEVLDQLLRGDNSIVYNFYLKNGSGSVYIGSVFLI
What are the official names of this protein?
Uncharacterized protein YGR121W-A.
Protein: PCRB_BACC0
Sequence: MYDISGWKHVFKLDPNKELSDEHLEMICESGTDAVIVGGSDGVTIDNVLHMLVSIRRYAVPCVLEVSDVEAITPGFDFYYIPSVLNSRKVEWVTGVHHEALKEFGDIMDWDEIFMEGYCVLNPEAKVAQLTDAKCDVTEDDVIAYARLADKLLRLPIFYLEYSGTYGDVELVKNVKAELKQAKLYYGGGISNAEQAKEMAQHADTVVVGNIIYDDIKAALKTVKAVKGE
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: HDOX_STAHJ
Sequence: MFVVTNRITVKKGFAEKMAPRFTKGGKIEALQGFHKIEVWKVTRDHENEDMYVNTWWETEKDFEAWTKSDAFKEAHQNRDKTSSESSPVISSEIVKATVLSTLN
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme oxygenase (staphylobilin-producing), Heme-degrading monooxygenase, Iron-regulated surface determinant, Iron-responsive surface determinant.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_LACP7
Sequence: MGMTMTQKILAAHANLPEVKAGQLIEANLDLVLANDITGPVAIHEIQRLKKKTVFDKDKIALVPDHFTPNKDIKSAEHCKCVREFAKEHDITNYFEIGEMGIEHALLPEKGLIVAGETCIGADSHTCTYGALGAFSTGVGSTDMGAGMITGKAWFKVPAAIKFILTGEPKEWVSGKDVILHIIGMIGVDGALYKSMEFVGAGIKNLTMDDRFTIANMAIEAGAKNGIFPVDDLTISYMKEHGAKPYTIYEADEDAEYEQIITINLSELEPTVAFPHLPENTKTVKEAGEVRIDQVVIGSCTNGRIGDLRIAAKVLEGRKVAKGMRAIVFPATQAIYLQAIEEGLIQTFIKAGCVVSTPTCGPCLGGHMGILAAGERAASTTNRNFVGRMGHVESEVYLCSPAVAAASAVTGKISEPSELFS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: AUSL_EMENI
Sequence: MSQLTISKIIEEPFSALSLSEMLKILAALGWSTNYLAMVYRTQADKLPAIAVLPLCCDIAWEFTYAWIYPQASGHWQGVVRVWFFLHTAVLAATLRYAPNDWAGTPLGESRGRLVLLYAAVIAAFAAGQLCLALEMGGALGFHWGGALCQFLSSSAAVGQLLTRGHTRGASLLIWGARAISTAGGDRALIGCVVSGAVPIDQKA
What is the function of this protein?
Terpene cyclase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759).  Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759).  Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).
What are the official names of this protein?
Terpene cyclase ausL, Austinoid biosynthesis clusters protein L.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y2274_BURMA
Sequence: MDARLLEILVCPICKGPLHYDRGAQELVCHADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGPARGR
What are the official names of this protein?
UPF0434 protein BMA2274.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: GLPG_ECOSM
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: E411_ADE05
Sequence: MIRCLRLKVEGALEQIFTMAGLNIRDLLRDILRRWRDENYLGMVEGAGMFIEEIHPEGFSLYVHLDVRAVCLLEAIVQHLTNAIICSLAVEFDHATGGERVHLIDLHFEVLDNLLE
What are the official names of this protein?
Probable early E4 11 kDa protein.
Protein: TSHR_BOVIN
Sequence: MRPTPLLRLALFLVLPSSLGGERCPSPPCECRQEDDFRVTCKDIQSIPSLPPSTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSGALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIGQDAFAGVYSGPTLLDISYTSVTALPSKGLEHLKELIARNTWTLRKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILQSLMCNESSIRGLRQRKSASALNGPFYQEYEDLGDGSAGYKENSKFQDTQSNSHYYVFFEEQEDEIIGFGQQLKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMRLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSPKNSTGIRVQKVPPDVRQSLPNVQDDYELLENSHLTPKQQDQTSKEYKRTVL
What is the function of this protein?
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin.  Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Plays a central role in controlling thyroid cell metabolism.
What are the official names of this protein?
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: S26A8_HUMAN
Sequence: MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
What is the function of this protein?
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport.  May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis.  May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells.  A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility.  May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
What are the official names of this protein?
Testis anion transporter 1, Anion exchange transporter, Solute carrier family 26 member 8.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the sperm cell.
Protein: BLI1_YEASO
Sequence: MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit BLI1, BLOC-1 subunit BLI1, BLOC-1 interactor 1.
What is the protein family that this protein belongs to?
Belongs to the BLI1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: FIS_SHIB3
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: SYFB_COREF
Sequence: MFIAQNWVTGLLGHSNPGWSVTSEELDAGYVRVGFETEGYAAIPATTGPLVLGVVESIEELTEFKKPIRHCFVNVGQANGTGENQSIICGARNFAEGDTVVVALPGAVLPGDFAIGARETYGRMSAGMICSAAELGLADKQNSGIITLPAESGQPGDDARAVLGLDDTVFEVNVTPDRGYALSARGLTRELASAFNLTYTDVAEDTRVAGIELTAPEPAGELIDIDVREETNTVRFGLRKVSGIDPNAESPFWLQRELMLCRQRPVNAATDVTNYVMMLLGAPMHAFDATKITGGLTVRNAQPGEKFETLDHVIRDLSGEDVVICDETGIQSMAGVMGGVTSEISNETTEVYFESAIWDPKTVARTSRRHKLSSEASRRFERGVDPAIVEVALDMACSLLVEIAGGTIDAGRTLIGEVPTMPSITMPVSRPSELAGVEYSPETVVARLEEVGCTVSVNGDVLTVVPPTWRSDLTMAADLVEEVLRLEGLEAIPTIVPTAPAGRGLSDAQKRRRAIGHALAYAGYAEIIPSPFMNPETFDVWGLDADDERRNTVTVLNPLEADSNVLSTTLLPSMLDAVRRNVTRGTGDFSLFGVQQVSFERGNGVSPMPSVKQRPSAEVVAELLDTLPEQPLHAATVGTGNIEFEGPWGSGRAYTYADAIESARIVARAAGIELELANADELPWHPGRCAALLVDGHVVGHAGELHPQVLERAGLPARTCAMEINIDALPLRENLPAPVLSAFPALHQDIALVVDETVPAEQVRAVVEEGAGELVETVELFDVYRSEQLGEGKKSLAFSLLFRAPDRTLTDEEANVARLAAAELAKERLGAEMRG
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_CLOB8
Sequence: MNIFEGNLVSEGLKFGIVVGRFNEFIGGKLLEGAIDGLKRHGVKEEDIDIAWVPGAFEIPLIAKKMAKSPKYDGVICLGAVIKGSTSHYDYVCSEVSKGIASVSLESGKPVIFGVLTTNTIEQAIERAGTKAGNKGYESAVSAIEMANLLNTIG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RA51D_HUMAN
Sequence: MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT
What is the function of this protein?
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.  Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity.  Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway.  Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment.  BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks.  The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.  Involved in telomere maintenance.  The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
What are the official names of this protein?
DNA repair protein RAD51 homolog 4, R51H3, RAD51 homolog D, RAD51-like protein 3, TRAD.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
Protein: YKOS_BACSU
Sequence: MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNLDSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAISQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLALWAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFLGSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHVMTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPKQKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPFNEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTLDTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSKKTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR
What are the official names of this protein?
Uncharacterized membrane protein YkoS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRC_SALCH
Sequence: MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVAGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVTERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFAELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_BURP0
Sequence: MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: TYPH_SALHS
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSKALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: GCH1_RALSO
Sequence: MLCSHDDDDPIRTAASHGIRRVRAFDAQRFELAVQSLLEASGIEIDTAHTGKTAQRVRELWQRRLLDGYDIDPAEALGHGFEDPRRDMVIIRSIAVHGVCPHHLLPFRGVAHVAYLPDGRLHGFGRIARMIDAISHRYTYQEWVTNEVAHALVAHGQARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFEQNMQARTEFLRAIKG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: EFTS_PLACH
Sequence: MRYSLFLEFFFVFVLTCSLDVICYKRTSSLNLVTDIKQIKNKSIHKRNRLYSSNENLKRLKYIREVTNASIQVCNDALKECNNDVDKAIELVRKNTKNGSFISTSVKTQKEGLICSDIMDDKIVLIELLTDSDFVARNNKFVTFLKNISKLCLHNEIIPPNIDVNDSVENFDTSLVAIDKIMQSPYTNSNGEINGTVSEELNYLRNIFREDIKIGRFSKYIKKNENEFLHYYIHNIVDGNNVGLSGVMLVIEIDNLNEKLKTKEKDIISFANDLCMHIISAKPVSVSIDKVNQNVVKKEMDIIRDSLKDLNKPENIITNMINGKMKKFYSNVVLLEQEYMLDDTKRKVSQVIKDFSKNNDLTINVKHFDNFIVGEKNILV
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, mitochondrial, EF-Ts, EF-TsMt.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KTHY_STAA8
Sequence: MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.