PharMolix/UniProtQA huggingface dataset:
Protein: ATG4_SCHPO
Sequence: MELMARFLERYLHFAPTNTEPPGTLIWFLGHSYKIEDSQWPEKFLYDSFSLITITYRSGIEGLENMTSDTGWGCMIRSTQTLLANCLRICYPEKQLKEILALFADEPSAPFSIHQFVTMGKTLCDINPGQWFGPTTSCSCVARLSDQNPDVPLHVYVARNGNAIYRDQLSKVSFPVLLLIPTRLGIDSINESYYDQLLQVFEIRSFVGITGGRPRSAHYFYARQNQYFFYLDPHCTHFAHTTTQPASEETFHSATLRRVAIQDLDPCMIFGFLIRDEEEWHSFEANQKYFADIVQIFDSEPQPVETHDDFVLDENVEDHL
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of atg8 (PubMed:23950735).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).  The protease activity is required for proteolytic activation of atg8: cleaves the C-terminal amino acid of atg8 to reveal a C-terminal glycine (PubMed:23950735).  Atg8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of atg8 during macroautophagy: atg8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of atg9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  Atg8 delipidation by atg4 also recycles atg8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated atg8 that is required for autophagosome formation at the PAS (By similarity).  Plays a role in meiosis and sporulation (PubMed:19778961).
What are the official names of this protein?
Probable cysteine protease atg4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: HSL39_DICDI
Sequence: MTLFSSISSMSTSMSGSKSSIASFGSGTSMGSNSIACGGGCGGSGGILGSGLGLGLGLDLTGGSRSRGACGNGGNRGNGNGGMGGGNGSCCGGPCCGI
What are the official names of this protein?
HssA/B-like protein 39.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: ODPB_STAES
Sequence: MAQMTMVQAINDALKSELKRDEDVLVFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAESGIGGLALGLAVTGFRPVMEIQFLGFVYEVFDEVAGQIARTRFRSGGTKPAPVTIRTPFGGGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLISSIQSNDPVVYLEHMKLYRSFREEVPEEEYKIDIGKANVKKEGNDITLISYGAMVQESLKAAEELEKDGYSVEVIDLRTVQPIDIDTLVASVEKTGRAVVVQEAQRQAGVGAQVAAELAERAILSLEAPIARVAASDTIYPFTQAENVWLPNKKDIIEQAKATLEF
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta.
Protein: T132A_MOUSE
Sequence: MTERKAAAPRGPYGAWFCLLVALALEVVRVSSNHDTLDPIYLPVALELLDAPEHFRVQQVGHYPPANSSLASRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHRACRFQPSLGACVVELQFPSHWFSQSATTRAELAYTLEPAGEGPGGCGLGTEEEPREQALPVGGVELHPEDPPQYQEVPLDEAVTLRAPDVPMRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVIAARPAQPTLWTAKLDRFKGSKHHTSLITCHRAGPAGPDSSPLELSEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGSAEGQLEPETAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIASLEGGRILVGREPGVTSIEVRSPLSDAILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGMSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVLPAEEQGAQLGVVVSGVGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPVPALPSSPVRTSPFTEATVEGKRQIAGDMGGHVGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVWLGTNQEELSRQLDRCSSSGPPKGEGGCPCESGAGGDASTVAPSASESPAGSSSTLARKEAGGRRKRVEFVTFAPAPPTQPPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS
What is the function of this protein?
May play a role in embryonic and postnatal development of the brain.  Increased resistance to cell death induced by serum starvation in cultured cells.  Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).
What are the official names of this protein?
Transmembrane protein 132A, HSPA5-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the TMEM132 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: EIF3A_MAIZE
Sequence: MATFAKPENALKRAEELIHVGQKQSALQALHDLITSKRYRSWQKPLEKIMMKYVELCVDLRKGRFAKDGLIQYRIVCQQVNVSSLEDVIKHFMQLSNEKAEQAKSQVEALEDALDVEDLEADKRPEDLMLSFVSGEKGKDRSDKEVVTPWFKFLWETYRTVLEILRNNSKLEALYAMTAHRAFQFCKQYKRTTEFRSCVRSIRNHLANLNKYRDQRDRPDLTAPESLQLYLDTRVEQLKVATELSLWQEAFRSVEDIHGLMTMVKKMPKPSILVVYYAKLTEIFWISDSHLYHAYAWLKLFNLQKSYNKNLSQKDLQLIASSVLLAALSVSPYDKKYGAFETENEKERNMRLSNLVNFSLDNKRENREMPSRPYLLSELASKGVLSCASQEVRDLYNLLEHRFLPLDLASKVQPLLLKISKIGGKLSSASSVPEVKLSQYISALEKLTTLRVLQQASCIFKSIKIDMLSRMIPFFDFSVVEKISVDAAKQNFVAIKVDHLSGVVQFGTVDIESDGLSDHLSVLADSLNKARIHICPPVKKPSKLGESLISLAAIVENEHKRLLARKSIIEKRKEELERQILEKEKEEEKKRMSSQKKTVDEERVRLLNEQRQREQDRIRREIEEKNKAEAKKMLEDLNKAGKKHVVVEGELTKEAYMELARNEQLKERHEMEKKLQKFAKTMDYLERAKRQEEAPLIEQAFQKRLEEEKILHEQEQLREIELSKQHHASDLQEKNRLSRMLEHKNALQERIIQERAAEFGRLKKERDERMNRLISSRKHERETVRKLMFYLNLEEQRIEMLREEEEARKREAEERRKREEAERKAKLDAIAEKQRLREIELEEKAKATREKLLKGSEAVRAPDSAPVAQPPRESAAAAAAAAAAAPAPSKYIPKFKRGGDSSSIPSGSRDEDRWGSRGPLRQDGPPARLDAPSSRQDTDRWRGSRFPSNSTSSSSTWSRSRN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 large subunit, eIF-3-theta.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDFZ_ECO57
Sequence: MTTYDRNRNAITTGSRVMVSGTGHTGKILSIDTEGLTAEQIRRGKTVVVEGCEEKLAPLDLIRLGMN
What are the official names of this protein?
Putative selenoprotein YdfZ.
Protein: YCHJ_SALPA
Sequence: MSQPCPCGSADEYSLCCGRIVSGERVAPDPSHLMRSRYCAFVMKDADYLIKSWHPTCNAAAFRDDIIAGFANTRWLGLTIFEHTWSEAENTGYVSFIARFSEQGKTGAIIERSRFIKENGQWYYIDGTRPQLGRNDPCPCGSGKKFKKCCGQ
What are the official names of this protein?
UPF0225 protein YchJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: SYT_CAMJJ
Sequence: MEKEVIAYLDNETIIDSQSVKNTNLKEIYFDNSKESLEVIRHSCAHLMAQAIKSLYPEAKFFVGPVIEDGFYYDFRVESKIGEEDLVKIEKKMKELAEAKIEISKYEITKSEALAKFQNDDLKQEVLLRIPDGAVSIYKQGEFEDLCRGPHAPNTKFLRFFKLTRVAGAYLGGDEKREMLTRIYGTAFADKESLKEYLTIIEEAKKRDHRKLGTELKLFTFDDEIGGGLPIWLSNGARLRSKLEHMLYKIHRLRGYEPVRGPELLKADAWKISGHYANYKENMYFTQIDEQEYGIKPMNCVGHIKIYQSDVRSYRDLPLKFFEYGVVHRHEKSGVLHGLFRVREFTQDDAHIFCMPSQIKEQVLEILAFVDNLMKLFDFSYEMEISTKPEKAIGDDEIWEIATKALKEALNEQGLKYGIDEGGGAFYGPKIDIKITDALKRKWQCGTVQVDFNLPSRFKLEYTDSDNEKKQPVMLHRAILGSFERFIGILTEHCAGEFPFFIAPTAVGIVPIGEAHIAYAKEIQKELLELNIDSEVYEKNESLSKKIRIAEKQKLPMILVLGDDEVVKRSVALRDRRAKEQKNLSLDEFIKLVKEKMSEVHF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_ACIBY
Sequence: MRVIVLGSGVIGVASAYYLARQGAEVTVLDRQSGPAEETSFGNAGQISPGYSTPWAAPGIPFKAVKWMFQHHAPLAINLDGSMWQLQWMAQMLKNCNPQSYAVNKERMMRVAEYSRDCLRELRKDTGIHYENRAKGTLQLFRKEAQMEAVQRDISVLEECGVSYELLNGNELGRVEPALANAQDKLVGGLHLPNDETGDCYLFTNALAQIAKELGVNFQFNQNVEKLIVEGDQIKGVQVNGKVLTADRYVLAFGSYSRDFLKPLDLQLPVYPVKGYSLTIPIVDPAFAPQSTVLDETYKIAITRFDQRIRVGGMAELSGFNLGLNEDRRATLQMVTQDLFPGGDMAQASFWTGLRPMTPDSTPIIGATRFKNLFLNTGHGTLGWTMACGSGKLISDIVLNHKTDISTDGLSIQRYSHAHAA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: RECR_RICPR
Sequence: MNKTNDIDQLIYLFSKLPGLGIRSARRIVLYLLQDKDVRLKSLINHLIELDKKIVKCEICGNLDTKSICHICSSEYRDKSTIAIVETVAELCAMERSGNFKGLYHVLGHNLSAASRQNPRILRLPELLKRCFVENIKEVIIATNSTLEGQTTAYFIIEYLKEHPAKISRLASGIPIGGELDYLDEGTLSAAISLRQPCE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: AB21I_ARATH
Sequence: MAEKNASAVDGAIRVSGMQFSYDVQDPIFFDFNLDLPAGSRCLLVGANGSGKTTLLKILAGKHMVGGKNVVQVLDRSAFHDTELVCSGDLSYLGGSWSKTAGSAGDIPLQGDFSAEHMIFGVEGIDPFRREKLIDLLDINLQWRMHKVSDGQRRRVQICMGLLHPFKVLLLDEVTVDLDVVARMDLLEFFKEECEQRGATIVYATHIFDGLETWASHLAYINGGELKLSAKLDEIKDLKTSPNLLSVVEAWLRSETKVEKKTKKKPVVTSPFMSSRQMAYYR
What are the official names of this protein?
ABC transporter I family member 21, ABC transporter ABCI.21, AtABCI21, GCN-related protein 1, Non-intrinsic ABC protein 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_ACIBS
Sequence: MFFAVITLFPEMFEAITAYGISGRAAKRDIVQVTCINPRDFAEGSYRRVDERPFGGGPGMVMMAEPLAKAINHAKQLASQAGCVHVPVVYMSPQGKTLNEQAVQQFVDYDGLIVLCGRYEGVDERLIQHYVDQEWSIGDYVLSGGELPAMVLLDSIIRRLPNVMSDEQSAIQDSFVDGLLDCPQYTKPDQFEGLDVPEILKSGHHANIEKWRFLQRYQRTLERRPELIEQVTLTKQQKKWLSDEQG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_ECOSM
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDETEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: Y1673_METJA
Sequence: MPKMFLLFSHKLTDDQINDARKNLKVDEFIYLPKELQELWSNIPPDVDDIDNYLKPIKEFLEKHAKPNDYVLIQGDFGATYKMVNFAIDKNLIPIYSTTKRIAKDIYKDGKIITIRKFKHCRFRKYNPY
What are the official names of this protein?
Uncharacterized protein MJ1673.
Protein: PXPA_RHOPT
Sequence: MKIDLNCDLGEGFGVWQMGDDAAMMQIATSVNIACGFHAGDPDIMHATVKLAKQNGVAIGAHPGFRDLHGFGRRPVPGITSAEIENLVAYQIGALQAVAALAGHKVTHVKAHGALSNVACEDDMTARAIASAIKAVDPSLVFVVLANSKLMLAGEAAGLPLAHEVFADRAYEDDGNLVSRKKPGAVLHDPNEIAERVLRMAQDGAVVSVTGKVIKMRTDTVCIHGDTKGAVEIARGVRRKLEASGITVAPFAGT
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: HRCA_ANAD2
Sequence: MASADELDRREREILRALVQDYIHTGEPVASQPLLSRHELEWSPATVRSVMADLEALGFLEKPHASSGRIPTERGYRLFVDTMLKVRPPSVADRDRIERLAQAAPDVSSLIEGTADLLHSLSHHAGVVTTPRPQADPVRQLEFVRLRENRVLVVFVSEAGIVTNKLVQLEFAMEPAELERAAAYLNEKLHARADAAELAALRAAILTDMRADQSALHDLLQKALVLAEQSFAGTGVEKVVMEGESSFLDAPEFSDVQKARALLRGFAEKDRILRVLDRVLTAQEVQIFIGAESEFATVPDVSVVAAPYGRGDRVLGTLAVVGPTRMNYARVIPLVDLTARQISRALAALSEGG
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GUN1_RUMAL
Sequence: MNSKKIGAMIAAAVLSLIVMTPAATRKIVQRQTRNSSTAVENSAADESETENVPVSQTHTNDTMTVTSAKDLVAKMTNGWNLGNTMDATAQGLGSEVSWLPLKVTTNKYMIDMLPEAGFNVLRIPVSWGNHIIDDKYTSDPAWMDRVQEIVNYGIDNGLYVILNTHHEEWYMPKPSEKDGDIEEIKAVWAQIADRFKGYDEHLIFEGLNEPRLRGEGAEWTGTSEAREIINEYEKAFVETVRASGGNNGDRCLMITGYAASSAYNNLSAIELPEDSDKLIISVHAYLPYSFALDTKGTDKYDPEDTAIPELFEHLNELFISKGIPVIVGEFGTMNKENTEDRVKCLEDYLAAAAKYDIPCVWWDNYARIGNGENFGLMNRADLEWYFPDLIETFKTYAEKDPASAE
What are the official names of this protein?
Endoglucanase 1, Cellulase, Endo-1,4-beta-glucanase, Endoglucanase I, EG-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: SYGA_SACD2
Sequence: MSKPDVSTFQGLILALQEYWAKQGCVVLQPLDMEVGAGTFHPATFLRAIGPETWNTAYVQPCRRPTDGRYGENPNRLQHYYQFQVALKPSPDNIQELYLGSLAHLGLDTNIHDIRFVEDNWESPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECYPVTGEITYGLERIAMYLQDVNSIYDLVWTKRPDGGIVTYGDVFHQNEVEMSHFNFSEANVEFLFQTFDVCEAESRRLIEKGLPLPAYEMVMKASHAFNLLDARQAISVTERQRFILRVRTLARDVAQAYFDARLKLGFPLADPKLRDEVIARVEAEMEKKA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JUN_SERCA
Sequence: MSAKMEPTFYEDALSAGFAPPESGGYGYNNAKVLKQNMTLNLSDPSSNLKPHLRNKNADILTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQNTLPSVTSAAQPVTSGMAPVSSMAGSTSFNTSLHSEPPVYANLSNFNPNALSSAPNYNANSMGYAPQHHINPQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
What is the function of this protein?
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.  May be involved in activated KRAS-mediated transcriptional activation of USP28.  May bind to the USP28 promoter.
What are the official names of this protein?
Transcription factor Jun, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Jun subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: STML1_HUMAN
Sequence: MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGADVPQSWPSCLCHGLISFLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTTGRGRVGHGVPDGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLRALK
What is the function of this protein?
May play a role in cholesterol transfer to late endosomes (PubMed:19696025).  May play a role in modulating membrane acid-sensing ion channels.  Can specifically inhibit proton-gated current of ASIC1 isoform 1.  Can increase inactivation speed of ASIC3.  May be involved in regulation of proton sensing in dorsal root ganglions (By similarity).  May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).
What are the official names of this protein?
Stomatin-like protein 1, SLP-1, EPB72-like protein 1, Protein unc-24 homolog, Stomatin-related protein, STORP.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein. Late endosome membrane. Membrane raft. Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle.
Protein: GCSH_BACC4
Sequence: MSIPNNLRYSEEHEWVKTEGNEVVIGITHFAQGELGDIVFVELPEVGATIEANEPFGSVESVKTVSELYAPVSGKVVAVNEELSDQPELVNESPYEGAWMVKVELSDASQVEKLLTAEKYAEMTNQD
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: AQPZ_PSEAE
Sequence: MKQYGAEFFGTFWLVLGGCGSAVLAAGVPELGIGYLGVALAFGLSVLTMAYAIGPISGAHLNPAVSVGLWVGGRFPASQLLPYVVAQVLGGLAAGGVLYLIASGKAGFDLAAGFASNGYGEHSPGGYSLQAALVSEVVLTGMFLLIILGATSKRAPQGFAPIAIGLTLTLIHLISIPVTNTSVNPARSTAVALYVGDWAVSQLWLFWVAPILGAVLGALAYRLIGDKND
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CASK_LAMGU
Sequence: YGINYYQHRLAVPINNQFIPYPNYAKPVAIRLHAQIPQCQALPNIDPPTVERRPRPRPSFIAIPPKKTQDKTVIPAINTVATVEPPVIPTAEPVVNTVVIAEASSEFITTSTPETTTVQITSTEI
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISF1_YEAS7
Sequence: MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKLASFSFENSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPASSTNNSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYGIPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPSSHLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSSPLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESIPHTSNCLEERNPRRKSFIKLSLASSFSN
What is the function of this protein?
Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover.  Participates in mitochondrial biogenesis (By similarity).
What are the official names of this protein?
Increasing suppression factor 1, Mitochondrial biogenesis regulation protein 3.
What is the protein family that this protein belongs to?
Belongs to the ISF1/MBR1 family.
Protein: IHFB_SALA4
Sequence: MTKSELIERLATQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ATPA_MAGSA
Sequence: MEIRAAEISAILKQQIATFGTEAEVAEVGQVLSVGDGIARVHGLDKVQAGEMVEFPGGIKGMALNLETDNVGVVIFGDDRNIKEGDVVKRTGSIVDVPVGKGLLGRVVDALGNPIDGKGPIEAASRQRVDVKAPGIIPRKSVHEPMSTGIKAVDALIPIGRGQRELVIGDRQTGKTAILVDTIINQKRWHDANDEKAKLFCIYVAVGQKRSTVAQIVKTLTDYGAMDYTIVVAATASEPAPLQFIAPYAGCTMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMGDAAGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETELFYKGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKLELAQYREMAAFAQFASDLDPATQKLLARGARLTELLKQPQFSPMATEEEVISIYAGVKGYLDKIDVRQVGRFESSLLSEIKSKAPEILTAIATEKQISAQTEEKLKAFLDAFSKTFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CYAY_HERAR
Sequence: MTESEFLKQAEATLDQIEATLEELANTSDLDVECTRSGNVLEIEFIDNGTKIIVNSQAPMQELWVAAKSGGFHFKAQGEQWMNTRDATELFAALSQMVSQQGGVEVVLRDAG
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: ACP_MAGMM
Sequence: MSDIAERVKKIVAEQMGVDLDKVTDDAKFVEDLGADSLDNVELVMAFEEEFGCEIPDETAEKITSVSDAIKYIGENME
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_BACAN
Sequence: MHEHLKEKLAILPDQPGCYLMKDRQGTVIYVGKAKVLKNRVRSYFTGSHDGKTLRLVGEIVDFEYIVTSSNLEALILELNLIKKHDPKYNIQLKDDKTYPFIKITAEKQPRLLITRNVKKDKGKYFGPYPNAQSAHETKKLLDRMYPLRKCSNMPDKVCLYYHMGQCLAPCVKEVTEEQNKEIVDEIIKFLNGGHKEVRSELETKMYEASEKLEFERAKELRDQIAHIDAIMEKQKMIMSDLVDRDVFGYAVDKGWMCVQVFFVRKGKLIERDVSMFPIYDEPEEGFLTFIGQFYENSSHFKPKEIVVPGSIDSELVERFLEVEATQPKRGKKKDLVELANKNAKIALEEKFYLIERDEERTIKAVENLGKQLGIETPYRIEAFDNSNIQGTNPVSAMIAFIDGKPAKKEYRKYKIKTVQGPDDYESMREVVRRRYTRALKEGLPLPDLIIIDGGKGHLAAASDVLENELGLYIPMAGLVKDDKHKTSHLIIGDPPEPVMLERNSQEFYLLQRVQDEVHRFAITFHRQLHGKSVIQSALDDIPGIGDKRKKVLLKHFGSLKKMKEASIEEFVEAGMPKNVAETIYTYLTDKKTL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.