PharMolix/UniProtQA huggingface dataset:
Protein: RL10_RUEST
Sequence: MDRAQKEKVVEELGQIFESSGVVVVAHYTGLTVSEMQDLRARARDAGGSVRVAKNRLAKIALEGKPCESMSDLLTGMTVLTYSEDPVAAAKVAEDFAKENKKFEILGGAMGENALDRAGVEAVSKMPSREELIASIVGCIGAPASNIAGAIGAPASNIASILSTIEEKAEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RS3_STRP4
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQKELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINIIEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: UBIE_SALPB
Sequence: MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMVGETGKVILADINDSMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RS3A_SULIL
Sequence: MSAKGGTIKDKWKMKKWYSIIAPKVFGEVSLGSTPAYDVTQTIGRRVETTLYDLTGDFSQVYVHLYFKIVSNEGDRLITRFVGHELSRDYLRSLIRRKSSKVNSVFDVTTKDGYVVRVKGLVLTTYKCHQSQKTAIRKIINETISKKASELTFDDFTQEVVFGRLANEIFEATKKIYPLRKAEIEKTKVLKVPENLGKQVESSSVSSG
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: HIS4_HAEIG
Sequence: MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKNPQSRQTALIGKIVEATQCKVQVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWFIKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETLIEDFQTVGLQQVLCTDISRDGTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLSEAIKCWQNG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_PEDPA
Sequence: MATKKNTRKRRVKKNIESGVAHIHSTFNNTLVMITDPQGNAVAWSSAGALGFKGSRKSTPFAAQMASEAAAKAAMEHGMKNVEVAVKGPGSGREAAIRALQATGLEVSAIRDVTPVPHNGSRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LPXC_CROS8
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIVEVDAPEIPIMDGSAAPFVYLLVDAGIDELNVAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDASNQRYCMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTYEDEAELPLAFKAPSLVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RS13_HELPS
Sequence: MARIAGVDLPKKKRVEYALTYIYGIGLKSSREILEAVGISFDKRVHELSEDEVSSIAKKIQQSYLVEGDLRKKVQMDIKSLMDLGNYRGIRHRKGLPVRGQTTKNNARTRKGKKKTVGSK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PGSA_CERS4
Sequence: MNWSIPNILTVLRLLAAPGVAVMFLYFHRPWADWFALTLFILAAVTDFFDGYLARLWKQESKFGAMLDPIADKAMVVIALVIITGYSGMNPWLILPVTLILFREVFVSGLREFLGAKASLLKVTKLAKWKTTAQMVAIAILFLGTGLEHLEGIARQGMTWEQYARAVSAGEADPIRSCGMHGCSSYATWLGLALIWIAAALTFITGWDYFRKALPYLKDEK
What is the function of this protein?
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SODC_NPVOP
Sequence: MKAICIVAGEASGRIYFKQGAPDEPVSITGYLLNLPRGLHGFHVHEFGDTSNGCTSAGEHFNPTRQRHGAPDAAERHVGDLGNVRSAGCTALTAIHMSDNVITLFGPLSILGRSLVVHTDRDDLGLGEHPLSKTTGNSGGRLGCGIIGVCAN
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Putative superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
Protein: GSA_BURPS
Sequence: MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLDATLDAARRAFAALRA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI15_HUMAN
Sequence: MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG
What is the function of this protein?
E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:34142270, PubMed:23077300).  Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368).  Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296).  Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300).  Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1.  Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740).  Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM15, RING finger protein 93, Zinc finger protein 178, Zinc finger protein B7.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: NUSG_BACSU
Sequence: MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEEETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLLPGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNMFGRETPVELEFTQIDKL
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.  Stimulates RNA polymerase pausing at U107 and U144 in the trp leader.  NusG-stimulated pausing is sequence specific.  Does not affect trp leader termination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: RUVC_VIBPA
Sequence: MSIILGIDPGSRITGYGVIRQQGRHLQYLGSGCIRTSEKELPGRLKQIYAGVTEIITQFQPDVFAIEQVFMAKNADSALKLGQARGSAIVAAVNADLPVYEYAARLIKQAVVGTGGADKVQVQHMVQHMLKLPAKPQADAADALGVAICHANTNKTLVALAGKASSARKGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: Y1725_METS5
Sequence: MIPGMLDEVLDVLEREGISYTLIEYPEKNRKSIDIIARGKQRRFVIKISNDRPSKEETRDLKNFSAVVGSMPVMVTDDTEEDIAIGKDNVIGLSVEGLAKALRGEKIFIYRTRGGIFIKIRSDVLRRKRTEMNYSMGDLSKILGVTRKTIYDYENGESDVSIEVAEKLIDLFGDEVIGDVCDDALPKLEPDSQPTDTISSRIAKNLTDAGFASAPIRFTAVDVVASRGLKKVLVTVEPKNQDQLEKKLREASKIANELMSELVIVVKSASMAKRLDKDGFKILTSESIDSLSDEINRSD
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein Msed_1725.
Protein: ATPL_SULNB
Sequence: MKKFFLLFLALGAVAFAGEGESMIKAYSVVAAGVGLGLAALGGAVGMGHTAAATIAGTARNPGLGGKLMTTMFIALAMIEAQVIYTLVIALIALYANPFIG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PC450_PENRW
Sequence: MLLLWFGFFSFVCGLVIYRLQFHPLSKFPGPKLAALTSLYEFYYNVVLGGRYLWEIERMHEQYGPIVRITPHELHVADPNFYTEIYAGPTRRRDKDPRLVRLAGQPTSMFATVDHGLHSSRRAILNNYFSKRSIAGLEDMIQGKVQKLVKRLNIACDQGTVVQLDAASSALTADIISEYAHGVSLDYLDDVNFNNEVADSILSLASVVHVLKFFPFLLDLSKFIPDKVLENLWSHAANILRLQKLVRAQADVALQNGGKVNGQATMFGALCDPSLPAQERTLDRLQDEGFSLIGGGTETTTGTLKVIMFHLLNEKALLRKLRKELEESPSGTWAELEKLPYMRGVMNEGLRLSGVITRLPRRAPDEALRYKQWTIPPNSLMSTSSHFVHTNSDLFPDPLVFDPERWIRAEAAGQRLEHMIVTFSKGSRQCMGNHLALAELYLVISTLVREFDMDLYGVTADNIVTHREYGFGVPKERGGGLRVSISRVRTP
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of conidiogenone, a diterpene known to induce the conidiation (PubMed:30343633).  The bifunctional terpene synthase PrDS converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into deoxyconidiogenol (PubMed:30343633).  The C-terminal prenyltransferase (PT) domain of PrDS catalyzes formation of GGPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GGPP into deoxyconidiogenol (PubMed:30343633).  The cytochrome P450 monooxygenase PrP450 then catalyzes two rounds of oxidation to furnish conidiogenone (By similarity).
What are the official names of this protein?
Conidiogenone synthase PchP450, Conidiogenone biosynthesis cluster protein PchP450, Cytochrome P450 monooxygenase PchP450.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LPT_SALPC
Sequence: MNRISTTTITTITITTGNGAG
What is the function of this protein?
This protein is involved in control of the biosynthesis of threonine.
What are the official names of this protein?
thr operon leader peptide, thr operon attenuator.
What is the protein family that this protein belongs to?
Belongs to the thr operon leader peptide family.
Protein: TEX37_MOUSE
Sequence: MARVVRPQKNHVDLDIYQSSYMVDYKPFGKYKYSRVTPQEQAKLDAQLQSKEFYQPKPNPNPKLEEGYPAFRRPYMTALDLGVPGFFPPQERVTTRKDDGRFTTTCHYAYPASLALYLAQQDPYWLHQRADFPCLMEPERQPAPEVGKGYLLLPGCLCDHHQRVKVPILNRWGPLMPFYQ
What are the official names of this protein?
Testis-expressed sequence 37 protein, Testis-specific conserved protein of 21 kDa.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Present in the germ cell lineage at all stages.
Protein: PXR1_CANGA
Sequence: MGLAAVKTRQKFGLDPRNTAWSNDQSRFGHKHLMRFGWQPGQGLGTQPVQSMKTHIKVSIKDDNLGLGAKLKKNKGDKIDEFDNGECAGLDVFQRILGRLNGKETEVNKELEIQRKDKILNGKWGVHFVKGDTLASTWDPKTKKLLSYSQMEKDSSSDEESDDDEDEKKKHKIEKKEAKKSKKRKRDSESDSESKKKKKSKKDKKEKKSKKDKKNKKEKESKKDKKSKHKKDKKQEIRTASIESSTSATSIPESVSTRLSVRSKWIKQKRAAVMDSKALNEIFMVTGN
What is the function of this protein?
Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
What are the official names of this protein?
Protein PXR1, PinX1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the PINX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SEPF_SYNE7
Sequence: MSFVNRIRDIVGLNESLDYDEEYETYDVAADSYNGYNDAAETSSRRRQRNHTPTASIEPVSTASNVIGLPGLSSSSEVVVMEPRSFEEMPQAIQALRERKTIVLNLTMMEPDQAQRAVDFVAGGTFAIDGHQERVGESIFLFTPSCVHVTTQGGEQYLNESPAQPVQTTTSFGRTATPTPAWGTDSRYAAQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: GRPE_AERHH
Sequence: MNHEEQKVEAMEQVEAQPVEPTDVDSEVTAEQARIAELEAQLDAAQQASLEERERAIRAVAEMENLRRRAAQDVEKAHKFALEKFAAELLPVLDNLERAIELADKENEALKPMIEGVELTLKSMQSSVGKFGLNPLDPLNQPFDPNAHQAMSMIENAELAPNTVIAVMQKGYELNGRVIRPAMVMVSKAPA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_BURCJ
Sequence: MEAERLNAIESSLLDLRNRAGELRGYLDYDAKAARLTEVNKELEDPNVWNDSKNAQALGREKKLLEGVVTTLTALDSDLRDALDLFELAREEGDEDTLLASEEDAAKLEARVGDIEFRRMFSNPADPNNCFIDIQAGAGGTEACDWASMLLRQYLRYCERKGFKAEVLEESDGDVAGIKNATVKVTGEYAYGFLRTETGIHRLVRKSPFDSSGGRHTSFSSVFVYPEIDDSIEVEINPADLRIDTYRASGAGGQHINKTDSAVRITHMPTGIVVQCQNDRSQHRNRAEAMAMLKSRLYEVEMRKRQAEQDKLESSKTDVGWGHQIRSYVLDQSRVKDLRTNVEMSNTRAVLDGDLDDFISASLKQGV
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_CLOBL
Sequence: MNKSRIDKQNEVYNFIKLQIKEKGYPPSVREICKAVGLSSTSSVHFHLKRLEKEGLIKRDSSKTRAIEIVDPTSKKEVINVPIVGTITAGNPILAIENIEDVFPLPIDYVKNTKDLFMLKVSGESMIEAGILDGDLAIIEKTDSANNGDIVVALIDNEATLKRFFKESSYIRLQPENKSMKPIILENCKVLGRLVGIYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RLMD_HAEIN
Sequence: MVLLYTPKQKTKNVQTITADILDLDYQGLGVAKINGKTWFIENALPHEKVECRILEDKRQYGHAIVKKWRVKSPERLEPKCAHFMRCGGCQGQHIPIEMQRKAKESALFKRLSKLQSEPISFQPMICGDAWAYRRRVRLSLWFNPSTKQIEMGFRQKNTNDLIPVQSCEVAEPAINYLLPKLTALLEKFSAPKQLGHIELVAADNGVAMLLRYTKNLAEIDRTLLLKFAEQEKLMLFLQSDKGIEQIYGDAPYYQFSDGIKLHFDIRDFIQVNSALNEPMVNTALDWLELSQQDCVLDLFCGMGNFTLPLAKRVKSAVGIEGVFEMVQKAAQNAERNQIKNIEFFQADLDQSFVEQPWANQSFNKILLDPPRSGAAFALNALCELKAEKILYVSCNPATLVRDAEILCNFGYKIEKSAVIDMFPHTGHLESITLFTTK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: DXS_SACEN
Sequence: MTLLESVQSPADVKRLEHGELAKLAAEIRSFLIEKVSRTGGHLGPNLGAIELTLAVHRVFDSPRDAVVFDTGHQAYVHKIVTGRQSGFDRLRKRDGISGYPSRAESEHDLVENSHASTALSYADGLARAFQLGSEQRHVVAVVGDGALTGGMCWEALNNIAADPDRPVVIVVNDNGRSYAPTIGGLAEHLAGLRLKPGYERALESGRRTLQNLPVVGRSLYTGLHAAKSGIKDALSPQVMFSDLGIKYLGPVDGHDLRSMEQALSMAKAFGGPVIVHAVTRKGNGFAPAENDVAEQMHQVKVIDPETGIPTKPAPKIWTDVYSDELVRIGAEREDVVAITAAMLGPTGLDKFAAAYPERCYDVGIAEQHAMTSAAGMAMGGLHPVFAVYSTFLNRAFDQLLMDVALHRQPVTVTLDRSGITGDDGASHNGMWDLSILGAIPGIQVAAPRDAVTLREELREAVAVDDGPTVMRFPKGSVIEEVPAVERIGGVDVLSKPASDERSEVLLAAVGAFGQLGVAVAERLAAQGIGVTVVDPRWVVPVPQAVLDLAARHSLVVTLEDCGRHGGFGWSLAAAMRDQEIDVPLRDLAVPNRFLQHASRDEVLSDLGLTEQDIARRITEWVAGRLTPVVVGNGRGETATGA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: INAM2_HUMAN
Sequence: MKERDAAPAERGKPATYTGDKKAKMAAKTNKKWVRLATVFAYVLSVSLAAIVLAVYYSLIWQPVGAGTSGGAAGPPPGGSNATGPSGTSGAAAAGPNTTGSSRREAPRDVPPLQAARPAPPEPPADSPPAGPLERPRGPDEDEEETAAAPGSR
What are the official names of this protein?
Putative transmembrane protein INAFM2, InaF-motif-containing protein 2, Osteogenesis up-regulated transcript 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: KAD_PROM3
Sequence: MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQSGGWLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGLLQTVEAQGSIESIAISIEKSLC
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_GADMO
Sequence: MTHQAHAYHMVDPSPWPLTGAVAALLMTSGLAVWFHFHSTTLMALGTVLLLLTMYQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHASLAPTPELGGCWPPTGITTLDPFEVPLLNTAVLLASGVTVTWAHHSIMEGERKQAIHSLTLTILLGFYFTFLQGLEYYDAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQIRYHFTSEHHFGFEAAAWYWHFVDVVWLFLYISIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GATC_CAUVC
Sequence: MAIDAATVRKVARLARIATPEERLEPLAQELNGIMTWIEQLAEVDTDGCEPLTSVVAAGLPLREDVVTMGGDPARVTSNAPKSINNFFVVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.