PharMolix/UniProtQA huggingface dataset:
Protein: SECA_CAMJE
Sequence: MFLNALKAVFGTKNDREVKKYFKRVAQINALEGNYQNLSDDELKAEFAKFKEQILSGEKNENDVLNDVFAIVRETGKRTLNMRHFDVQLIGGMVLHDGKIAEMKTGEGKTLVATLPVVLNAMSGKGVHVVTVNDYLAKRDAEQMSAIYNFLGFSVGVVLSSQNSDIEHKQAYDCDITYGTNNEFGFDYLRDNMKFSKAEKVQREHNFVIVDEVDSILIDEARTPLIISGPTNRTLDGYIKANEVAKQMQKGEAVLPPAKPEGDFVVDEKNRNILITEAGIAKAEKLFGVENLYSLDNAILAHQLDQALKAHNLFEKDVHYVLRNNEVIIVDEFTGRLSEGRRFSEGLHQALEAKENVKIQEESQTLADITFQNYFRMYNKLAGMTGTAQTEATEFSQIYSLDVISIPTNIPIKRQDKDDLIYKTQNEKFKAVIEEIKKANAKGQPVLVGTASIERSEVFHNMLVKEKIPHHVLNAKNHEQEALIIQDAGKKGAVTIATNMAGRGVDIKIDDEIRALGGLYIIGTERHESRRIDNQLRGRAGRQGDPGISRFYLSLEDNLLRIFGGDRIKSIMDRLGIEEGESIESRIVTRAVENAQKKVESLHFESRKHLLEYDDVANEQRKTIYRYRNELLDENYDIRAKISQNIAEYSANVMNDYMLDESGSNVNFENLKAKILYECSTQISEKDFENLSVIEMQDKLSQILENSYNEKMLRLEIKELRNIERILYLQVLDNAWREHLYQMDILKTGIGLRGYNQKDPLVEYKKESYNLFLELVNRIKFDSIKLLFSVQFNQEEAQNLENKANEENEKLLQSSVEMGASEDNLGEAEFKKVPRNAPCPCGSGKKFKECHGKSGPKQGILA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: TRMN6_YERP3
Sequence: MGEQLKKQPVLRGGGFTFKQFFVAHDRCAMKVGTDGVLLGAWVPVLHARRVLDIGCGSGLIALMIAQRSLPQVQIDGVELEPAAAQQASSNVELSPWAERIHIHQQDIHQFAENHPHQYDLIVSNPPYFAPAIACRDEARDTARYTGSLTHDALLNCAEKLITEDGMFCVVLPHELGIEFARLAGQQGWFVRCQVDIRDRPGKPLHRMLLTLSRQAGETVYQHLALRQSEGVYSPEFCQLISDFYLNY
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDKB_MERME
Sequence: TFVAIKPDGVQRGLCGEVMKFIQPMKQHYLDLKDMPFYAGLCKYMSSGPVFAMVWEGEGIVKMMLGETNPADSKPGSIRGDFCINIGRNIIHGSDTVENAKMEVALWFKPEEFVTYTEKAKAWVYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.
What are the official names of this protein?
Nucleoside diphosphate kinase B, NDK B, NDP kinase B.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle.
Protein: YO098_YEAST
Sequence: MGFKKLVSFQPDYVPQYHITKYISERTKLQLVHINHKTSPLVHGYFAVPTECLNDSGAPHTLEHLIFMGSKSYPYKGLLDTAGNLSLSNTNAWTDTDQTVYTLSSAGWKGFSKLLPAYLDHILHPTLTDEACLTEVYHIDPENLGDKGVVFSEMEAIETQGWYISGLEKQRLMFPEGSGYRSETGGLTKNLRTLTNDEIRQFHKSLYSSDNLCVIVCGNVPTDELLTVMEEWDNKLPEIPSNIPKKRPFLDNKLSHIPQSRDKVTESTVEFPELDESQGELLFSWIGVPYSDFRNDLAVDVLLDYFTDSALAVFTRELVEIDDPMANSTDCCTDYFMRTIIDLRIQGVPTEKIAATKTKVLEILKTHTIDLSRVRQVVENTKWEYLLNYEKNGESRFSSAVITDYIYGNEDGSSLVSSLKDLSDFDALLQWSQKDWQSLLNRIFVDNKPIIVTAKPSALMYEQLEKEKSDLIKQREAEFDDEKKLVLLKRLNNAKNINDRPIPKSLLQKFEIDNPSKSVEFVNTKSIATVDSYKYNNVSDPLTKKILETRPDNFPLFIHLNHFPSQFIELHFLVNSASIKDTSLLPYFNMFDELFSMPMKILDEESNVETMLSFEEVVAKLKSETIDAQINQGLKGSCPDLINFKIQCRAGGYSNSVQWIKHCLFDMVFDENRVRILLENYLNSIVEWKRNGNVMLSSLTNRNLYSARSLKKSTDPLFVEAKLQEIFAEIENGNFEKEILPRIETMRKQLRANFNKFHILVLGDISKIDDVYEPWNPLIKCLNIAHPVEKLKIPPVPRALDTISSICRTPGEKAFIITTPASESAYMNLITSIPFNLDYHDPEYAIVSLASEYLECVEGPFWKGIRGAGLAYGASMLKLCEINSWGFNIYRGADIIKCYEVGKQIVQDYASGALEFDEQLIQGAISSIINRLATIECGYFETALSKYVDEFCLQRGNNFNELYLERLQNVTKTDLKNAMQKYFVNMFDSNKSVAFVSCHPAKLESVQEFFETQGFTVEIEELEDDDDEIDSEEDENA
What are the official names of this protein?
Uncharacterized protein YOL098C.
Protein: MTNC_SHESR
Sequence: MGIRAIVVDTAGTTTDLTFIQDVLFPYSVKALPDFLAQNQHNVLVENCICDTRDIALEPDADLARVTEILQQWVHEDRKATPLKTLQGLIWKQGYAHGEFTGHIFPDFIEAVNRFSAQKLRIYSFSSGSVEAQKLLFSHSDGGDLTEMFSGHFDTRTGNKLDKQAYANILNTISLSPKQVLFVSDVVEELKAAEAAGMMTCQMVRDSKQRTGDFRTINSFDELVID
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: COMB_SYMTH
Sequence: MVNIPPAEELAGRVAVVIDVLRATTTICTALANGADTVVPILSPEEAFQVARDNPDRQFLLGGERKAVLIPGFHCDNSPLEYTEARVKGRPILFTTTNGTRAIRRAAGADRVYIASLLNAPAVGRELARLEVDVAICCAGTHDQFSLEDTVCAGAILEYMAGPDRPVETNDMGLVARELFRRYDGRLADLLHLSSHGQNLVRLGMQDDLLFCAQLGTLTILPVFTEGQVVLLE
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: RUVB_STAS1
Sequence: MDDRMVDQSMHDEESSFELSLRPTKLRQYIGQSTIKSNLEVFIKAAKMRQEPLDHVLLFGPPGLGKTTLSNIIANEMEVNIRIISGPSIERPGDLAAILSSLQPGDVLFIDEIHRLSSVVEEVLYPAMEDFFLDIVIGKGEEARSIRIDLPPFTLIGATTRAGSLTAPLRDRFGVHLRLEYYQELELKEIIVRTAEVLGTSIDDESAIELAKRSRGTPRVANRLLKRVRDFQQVNEDELISIATTRASLQLLQVDDEGLDYIDHKMMNCILEQYKGGPVGLDTIAVSIGEERVTIEDVYEPFLIQKGFIERTPRGRKATPYAFEHFSKKNGKKE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AB11B_ARATH
Sequence: MNGDGAREGDSVSHEPSTSKSPKEGEETKKEEKSEEKANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVKTSELSSGSSFRNSNLKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPAHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQLHMTASN
What are the official names of this protein?
ABC transporter B family member 11, ABC transporter ABCB.11, AtABCB11, Multidrug resistance protein 8, P-glycoprotein 11.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL35_FRACC
Sequence: MPKQKSHSGASKRFRVTGSGKVLRQRANRRHYLEHKTSRLTRRLDGVVPLTKADNRRVKRLLAR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DCUP_SHISS
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5283_DELAS
Sequence: MLLLLSPAKSLDYDTPLPPKLPHTLPVFSEQPLELIEVLRRQSPQQLSELMGISDKLAALNVARYEAFSPRFTATNARQALLAFNGDVYEGLQARSLDAEDLDWAQQHLAILSGLYGVLRPLDRMQPYRLEMGTRLETAHGSNLYQFWGSRIAEHLNQRAARQPAGERVIVNLASQEYFKSVDLKHLKPPVVECAFEDYKNGAYKIISFHAKRARGLMARFAIQRRARSAAELEAFDLEGYALAPASSTPARLVFRRKTAD
What are the official names of this protein?
UPF0246 protein Daci_5283.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: SLX1_NEMVE
Sequence: MDDNIAGSGFHGVYLLYCVNPKFKGHTYIGYTVNPNRRIKQHNGGVDKGGAYKTSRKKPWNMILIVHGFPNDIIALQFEWAWQKPTVSRRLKSAATKKKPRERPVQYCFRILSELLRVGPWNRLPLHIRWLMREYEMEFDPRCLPPFHMTVVYGPLVSRKAKQKAVSSEDQRPDHKEKCIKCLDVIKIDEKLIRCPKSGCTMTAHMFCLARDFLHCGNEGGLFCLPVDGNCPQCKGSLLWGDLVKPAESIPSAEDVDEDTDDHWTQGLRL
What is the function of this protein?
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRRM5_HUMAN
Sequence: MSSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA
What are the official names of this protein?
Serine/arginine repetitive matrix protein 5.
Protein: GRPE_YERPP
Sequence: MSSKEQKTPNEQVSEEMENTAEQQVEATQETGECVDPRVAELEVQLSDALQRERESLLRAKAEVENIRRRTELDVEKAHKFALERFSSELLPVIDNLERALDTADKTNTELTSMIEGVELTLKSLLDAVGKFGIEVVGETHVPFNPEVHQAMTMLESADHEPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNTF_STAA8
Sequence: MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKEVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
What is the function of this protein?
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP).  Involved in the import of divalent metals ions such as nickel, cobalt and zinc.  Probably responsible for energy coupling to the transport system (PubMed:23279021, PubMed:29581261).  Plays a major role in nickel/cobalt import in zinc-depleted conditions.  Contributes to virulence.  Required for full urease activity in vitro (PubMed:23279021).
What are the official names of this protein?
Metal-staphylopine import system ATP-binding protein CntF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DXR_NOSS1
Sequence: MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILLGGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLKKILLTASGGAFRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIVIHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGGSMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: IL23A_HUMAN
Sequence: MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP
What is the function of this protein?
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383).  Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:32474165, PubMed:29287995, PubMed:33606986).  This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369).  In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165).  Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044).
What are the official names of this protein?
Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
Protein: HST1_EMENI
Sequence: MDLASAPRGESPPLKAPLVEIEAAEVERSLPQENAAPEEKGSNSQSEYESDSDALDDEWETQSLYEDAIQMIRDDQLRDGTIPGACTLEEAIEFRKRLHEVGKAQFVEETIARDTVTAKKLCTAFGILPPSFLEGAPDEAYHPLLAIAISREFARRQKLPQYNSVDDAVKLLKESKNIIVLTGAGISTSLGIPDFRSKDTGLYSKLENLGLNDPQEVFDIRIFREDPGIFYSIAKDILPTEKKFSPTHGFIRLLQDKGKLLTNYTQNIDNIEANAGVFPENIVQCHGSFATATCVKCQYKVAGDEIYDDIKKGLIPECAQCRKRIAEDSQKPQGQKRKRNSTSAHKDRSKSGEDSSDGEDYEIPTPGVMKPDITFFGEDLPDEFGRRLLHHDRDKVDLVIVIGTSLKVAPVAEVPGVLPPHIPQIYISRTPVAHTNFDIDLLGDCDVVVSELCRRAGWELKHEMISPDEKVDVTPVFGYGSRHVFKVSG
What is the function of this protein?
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
What are the official names of this protein?
NAD-dependent protein deacetylase hst1, Homologous to SIR2 protein 1, Regulatory protein SIR2 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4060_BACAN
Sequence: MGFPKVERLLINYKTLDEFKKFKGCGAQELSMLEELQANIIENDSESPFYGIYYGGSLIARMSLYMKRNGGEPFEITGTYLELYKLEVLPNFQKQGFGEMLVNYAKGLQFPIKTIARIHSAGFWDKLNFQPVSVPDGDFYVWHPETNLNAVTNEESA
What are the official names of this protein?
Uncharacterized N-acetyltransferase BA_4060/GBAA_4060/BAS3772.
Protein: RL13_BDEBA
Sequence: MKTFNAKAEEVERKWWIVDAAGQKVGRVATHVATILRGKNKAIYTPNVDTGDFVVVINTDKMELSGTKWQDKKYYSHTRFFGSLKEMTAAQAKEKDSTFIIHEAVRGMLPTNKLSRHVIMKMKAYTGAEHPHAAQKPALFTLPSKK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: VP1_POVHA
Sequence: MCKPLWKPCPKPANVPKLIMRGGVGVLDLVTGEDSITQIEAYLNPRMGQNKPGTGTDGQYYGFSQSIKVNSSLTADEVKANQLPYYSMAKIQLPTLNEDLTCDTLQMWEAVSVKTEVVGVGSLLNVHGYGSRSETKDIGISKPVEGTTYHMFAVGGEPLDLQGLVQNYNANYEAAIVSIKTVTGKAMTSTNQVLDPTAKAKLDKDGRYPIEIWGPDPSKNENSRYYGNFTGGTGTPPVMQFTNTLTTVLLDENGVGPLCKGDGLYLSAADVMGWYIEYNSAGWHWRGLPRYFNVTLRKRWVKNPYPVTSLLASLYNNMLPTIEGQPMEGEAAQVEEVRIYEGTEAVPGDPDVNRFIDKYGQQHTKPPAKPAN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with sialic acids on the cell surface to provide virion attachment to target cell.  Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: AMPA_SALSV
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMRELGMNAYLAVGHGSQNESLMSVIEYKGNPSEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASEQAGDRAWRLPLGDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAO4_ARATH
Sequence: MDKKKNSFPDNLPEGTISELMQKQNNVQPSVIVIGSGISGLAAARNLSEASFKVTVLESRDRIGGRIHTDYSFGCPVDMGASWLHGVSDENPLAPIIRRLGLTLYRTSGDDSILYDHDLESYGLFDMHGNKIPPQLVTKVGDAFKRILEETEKIRDETANDMSVLQGISIVLDRNPELRQEGMAYEVLQWYLCRMEAWFAVDANLISLKCWDQDECLSGGHGLMVQGYEPVIRTIAKDLDIRLNHRVTKVVRTSNNKVIVAVEGGTNFVADAVIITVPIGVLKANLIQFEPELPQWKTSAISGLGVGNENKIALRFDRAFWPNVEFLGMVAPTSYACGYFLNLHKATGHPVLVYMAAGNLAQDLEKLSDEATANFVMLQLKKMFPDAPDPAQYLVTRWGTDPNTLGCYAYDVVGMPEDLYPRLGEPVDNIFFGGEAVNVEHQGSAHGAFLAGVSASQNCQRYIFERLGAWEKLKLVSLMGNSDILETATVPLQISRM
What is the function of this protein?
Flavoenzyme involved in polyamine back-conversion (PubMed:18703589, PubMed:20532512, PubMed:21081665, PubMed:26925084).  Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and spermidine (PubMed:18703589, PubMed:20532512, PubMed:21081665, PubMed:26925084).  Substrate preference is spermine > spermidine (PubMed:18703589, PubMed:21081665).  No activity detected when putrescine or N(1)-acetylspermine are used as substrates (PubMed:18703589).  Plays an important role in the regulation of polyamine intracellular concentration (Probable).
What are the official names of this protein?
Probable polyamine oxidase 4, AtPAO4, Amine oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
Protein: ECFA1_STAAB
Sequence: MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVSEALKQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTAIEIFDHAEGLTTIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.