PharMolix/UniProtQA huggingface dataset:
Protein: NADE_LISW6
Sequence: MEIRKRILADMQVAETIDAHEEIRKSVEFLKAYLKKNTFLKSFVLGISGGQDSTLTGKLAQLAISEMRDETGDNEYQFFAVSLPYGTQLDESDRQDALNFMNPDNRLTVNIKASVDASVAALAEAGVELSDFAKGNEKARERMKVQYAIAAMHKGVVVGTDHSAEAVTGFYTKYGDGGTDINPLFRLNKRQGKALLKELGCPEHLYLKKPTADLEDNKPALPDEVALGVTYDQIDDYLEGKEVPADAAAKIENWFIKTEHKRHMAITIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: DIPP_ASFM2
Sequence: MQLKTSIGLITCRMNTQSNQIETILVQKRYSLAFSEFIHCHYSINSNHSHLIKMFNNMTINERLLIKTLDFDRMWYHIWIETPVYELYHKKYQKFKKNWLIPDNGKKLISLINQAKGSGTLLWEIPKGKPKENESDLACAIREFEEETGIAREDYQILPEFKKSMSYFEGKTEYKHIYFLAVLCKSLEEPNMNLSLQYETRIAEISKISWQNMEAVRFISKRQSLNLEPIIGPAFNFIKNYLRYKH
What is the function of this protein?
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells.  May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins.  Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis.  In addition to the mRNA cap, g5R also efficiently hydrolyzes diphosphoinositol polyphosphates.  Down-regulation of the level of PP-InsP5 (diphosphoinositol pentakisphosphate) may play a role in viral manipulation of the cellular secretory pathway, a step necessary for the formation of virions.  Binds viral and cellular poly(A) mRNAs, thereby decreasing both types of mRNAs.
What are the official names of this protein?
mRNA-decapping protein g5R, g5Rp, ASFV-DP, Diphosphoinositol polyphosphate phosphohydrolase, DIPP.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DIPP subfamily.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum. Note=Accumulates at the periphery of the viral factories.
Protein: C3H62_ORYSJ
Sequence: MAAPAADDDDHRAALPREEDDGEEEEGSEEEVESDDEEEEEGEGYDWSEEDDPEAASLAGICDPDAGSYDDPTFDPAADGDLEVDAVLRSRMARMSLSSARKDRKGSRMPKMGKEEMDLLAMVDKLMHDGQLEKLKVYECKAYLRMHKLRLSGNKEVLLTRIRGQIEVKTMGEVKYPVSSFVLNCQGDSCKGDVVVFEQNIYKRKKGAPRGVKGHLCGQRTNAGRIIKESYGTKKQQHTFTIEILWSRGYKPWPPLHPLLIKGRNLYKDKTMRQPWLDEEERNRALQEKHARGYVARKTREVRIKDKENERMRRLNRNKENKSKGQDNMNKKSSQAVFPQHTVTTNTVQKRAEKIIPSLQHGESGNSSQQHLSSKQTPTEQLLHYLPQFPHPQQHNEVLLQKGTSRTSTTQLINHQAPSLQHAVKVETTQQQQQQQPPKSIKPAPIQQSSAYPQQYPKHQHHNQALPRVPPSQEQRAAVSQTSAARQDFTNHQAPPSRQHGGSENMRRQEISSRPTPTPTPQQAVSYTQQQPPNHQYRNEAFWQQGGTSTSRTGFMDRQSNNWGSTDHDKPAFQPFTQKAKTYQHGSNGSGHHQARVDRETHQPLRSRNQDYHWEDQSYHHQQNHHQNYYGHRQMSQDQYHHQQNHHQNYHGRQGMNGNQYHDRQNHNQNPQRFRPWKPCFIYQQQGWCPYGENCKFMHDLR
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 62, OsC3H62.
Protein: ELIB_PHYDR
Sequence: TTCTSTQQTAAYTTLVSILSDSSFNKCASDSGYSMLTAKALPTTAQYKLMCASTACNTMIKKIVSLNPPNCDLTVPTSGLVLNVYEYANGFSTKCASL
What is the function of this protein?
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families.  Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins.  Might interact with the lipidic molecules of the plasma membrane.
What are the official names of this protein?
Beta-elicitin DRE-beta.
What is the protein family that this protein belongs to?
Belongs to the elicitin family.
What are the subcellular locations of this protein?
Secreted.
Protein: IVD_BOVIN
Sequence: MATAAWLLGRRVASWRMRPPLQSLAGLITQRTNSLLPVDDAVNGLNEEQKQLRQTVAKFLQEHLAPQAQEIDQSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGFLENVLVMEEISRVSGAVGLSYGAHSNLCINQIVRNGNETQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDVTAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELVFEDCEVPAANILGHLGKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHMREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTTKDCAGVILYSAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
What is the function of this protein?
Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway.  To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
What are the official names of this protein?
Isovaleryl-CoA dehydrogenase, mitochondrial, IVD, Butyryl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: AUKBB_XENLA
Sequence: MSYKENLIPSSCSSSSSSSSKFATPSSATAAQRVLRKQPYVSIFTTPSDNLLAQRAQLAPRVTPAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHSETHRRIVNVDLKFPPFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVKANSRRVLPPVYQSSHPK
What is the function of this protein?
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.  Required for central/midzone spindle assembly and cleavage furrow formation.  Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage.  Phosphorylates 'Ser-10' of histone H3 during mitosis.
What are the official names of this protein?
Aurora kinase B-B, Aurora/IPL1-related kinase 2-B, AIRK2-B, XAIRK2-B, Serine/threonine-protein kinase 12-B, Serine/threonine-protein kinase aurora-B-B, xAurora-B-B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12.
Protein: OMPR_SALTS
Sequence: MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
What is the function of this protein?
Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:2543631).  Plays a central role in both acid and osmotic stress responses.  Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (Probable).
What are the official names of this protein?
DNA-binding dual transcriptional regulator OmpR, Transcriptional regulatory protein OmpR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1359_LEVBA
Sequence: MAEPTMDSLLARINELAHKNKTDGLTDEETAERDHLRKQYLKLFRESFRSQVEMMQVYDKAGKEVTPEKVRQIQRDKGLRDD
What are the official names of this protein?
UPF0291 protein LVIS_1359.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_CHRVO
Sequence: MAIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVEMVLGNHDLHLLAVSEGFGKIHRDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAGLLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTRWTDDLKGVDRLRLIVNVMTRMRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAIDSGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: DXS_SYMTH
Sequence: MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFDSPRDKILWDVSHQSYVHKLLTGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSISAAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAGHDKTKVIVVLNDNSMSIAPNVGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFEDLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPFDVATGRTGPGSLTYSEVFGNVMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVGIAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDVALQNLPVTLAIDRGGLVEDGATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDETLQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELLLRAGREVGAVVTVEEACLAGGFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLERYGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGAKAAGNGET
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: URE3_PROMP
Sequence: MHLSPQEKDKLLIFSAAQLAERRLNRGLKLNYPETVAFLSFQVLEGARDGKSVSQLMSEGTTWLSKKQVMDGISEMVDEVQVEAVFPDGTKLVTIHNPIN
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERP1_RAT
Sequence: MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM
What is the function of this protein?
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.  Protects unfolded target proteins against degradation during ER stress.  May facilitate glycosylation of target proteins after termination of ER stress.  May modulate the use of N-glycosylation sites on target proteins.
What are the official names of this protein?
Stress-associated endoplasmic reticulum protein 1, Ribosome-attached membrane protein 4.
What is the protein family that this protein belongs to?
Belongs to the RAMP4 family.
Protein: MP_ACLSA
Sequence: MMIRGHKLKIAEGDIPIAGVKSSRIYSDVSPFRKASDLMIHWNEFVFKVMPEDIAGDGFRLASIPVIPSSEVQAVLRKRESTNYVHWGALSISIDALFRKNAGVSGWCYVYDNRWETFEQAMLQKFRFNLDSGSATLVTSPNFPVSLDDPGLSNSISVAVMFENLNFKLESYPISVRVGNMCRFFDSFLSCVKNKVDSNFLLEAANADPLGAGAFGFEQDDQVSELFNYIQTVPTQAIKSREHEVPRGLFGMMGKKKVKSFEFASGSRNLGRRKPQRGRPLERSASLRVAPGFRSQDERVEHQGLSTDSDFENFLRKGKGKAGTESITSEGSSFDNISAREFQFARQDQKAKDGGSAEPPIKSGRRSESVPGRRRQTPSWKDRGNSGTDTGGHLREHSDTGDLGTNRVPGRAGGGEIHGGSEGGGVIQSEGGSRFDQNIQDYIFGPEYKQHDLPPSV
What is the function of this protein?
Suppressor of viral-induced RNA silencing.
What are the official names of this protein?
Putative movement protein, 50.4 kDa protein, ORF2 protein.
What is the protein family that this protein belongs to?
Belongs to the tobamoviruses movement protein family.
Protein: Y644_SHESA
Sequence: MEKIFERLMYASRWIMAPIYLGLSLVLLGLGIKFFQEIFHILPIIFEMTEVDLVLVTLSLIDITLVGGLIVMVMFSGYENFVSQLDVGEDSEKLSWLGKLDSGSLKNKVAASIVAISSIHLLKIFMDVKNIDNDKIMWYLLIHITFVVSAFAMGYLDKMTRK
What are the official names of this protein?
UPF0114 protein Shewana3_0644.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRC_HELHP
Sequence: MSNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVPKNNLSPRIALMVSQITRIHTLLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYIDKSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDNLPLVQKKSCVKGKKACIFHQIHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDRIQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRIISSDFILLHDDIQSHNLPQLYTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQTRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTFSTLVSIKELCVLSQIPYSIEVFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPPALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKLKPNDKRLQFLQKLRDEVHRYAITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFESLKTASQEQINSVLSRRNRSDT
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_METM5
Sequence: MIKDERWEGVYSFEDSPYLMETLTDLRKISTENISFRKGLVRLGRYMGYELTKTMEFEKMPIQTPLEKTEGVFAKDRKNVVIITILRAAFPLMEGLIKNFESAKVGIVSASRGHAPDFKIEMNYIKVPQLNPEDTVIVSDPMIATGSTLIHVLKEFRDSKPKRMMIVGVLAAPEGINAVKKEFSDVEIFVTKIDENLNKDGYIVPGLGDAGDRAFGEPFKVPMLPQMHNLE
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PYRH_MARN8
Sequence: MPTSSKNQPRYKRVLLKLSGEALMGEHDFGIDPKVLDRMALEIGALIGIGVQVGLVIGGGNLFRGAALNAAGLDRVTGDHMGMLATVMNGLAMRDALERSNIRTRVMSAIPMSGIVEHYDRRRAVRDLKEGDVVIFSAGTGNPFFTTDSAACLRGIEIEADAVLKATKVDGVYSADPHLDPTAVKYDHLTYDEVLDKKLGVMDLTAICLARDHGMPLRVFDMNRPGVLTRIVTGEREGTLIE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_CLOBJ
Sequence: MANIKSAKKRIKVIETKTLRNKMLKSSLKTTIKNFLTVVEGKNVEEAKAAYKTAARALDMSVSKGIVHKNKAARTKSRLAAKLNALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: HOX6_ORYSI
Sequence: MDGEEDSEWMMMDVGGKGGKGGGGGGAADRKKRFSEEQIKSLESMFATQTKLEPRQKLQLARELGLQPRQVAIWFQNKRARWKSKQLEREYSALRDDYDALLCSYESLKKEKLALIKQLEKLAEMLQEPRGKYGDNAGDDARSGGVAGMKKEEFVGAGGAATLYSSAEGGGTTTTTTAKLMPHFGSDDVDAGLFLRPSSQHHPPPPHAGAGFTSSEPAADHQSFNFHSSWPSSTEQTCSSTPWWEFESE
What is the function of this protein?
Probable transcription factor that binds to the DNA sequence 5'-CAAT[AT]ATTG-3'.
What are the official names of this protein?
Homeobox-leucine zipper protein HOX6, HD-ZIP protein HOX6, Homeodomain transcription factor HOX6, OsHox6.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNC_VIBPA
Sequence: MNSPIDKLERKLGYQFKDAGLINLALTHRSANSKHNERLEFLGDSILSFVIADDLYHRFPKVNEGDMSRMRATLVRGHTLAELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDIEKVRSIVLSWYNSRLEAIKPGVSQKDPKTRLQEFLQGRRKPLPVYTVTNIKGEAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLTNG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENH_CITK8
Sequence: MILRAQANGGQPGSPWLVFLHGFSGDCREWQQIGEQFPDFSRLYIDLPGHGDSADIRVSGFADVCDLLRNTLFSYNILKYWLVGYSLGGRVAMMAACQTLPGFCGLVVEGGHPGLQREAERDARRRSDGRWAARFRREPLRDVFTDWYQQPVFASLDASQREALVALRSQNNGETLAAMLEATSLAVQPDLRARLNARTFPFYYLCGERDSKFRALAAELSVPCHMIRNAGHNAHRENPAGVVDSLAQILRL
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: RF3_YERPY
Sequence: MSPSEYALEVAKRRTFAIISHPDAGKTTITEKVLLFGHAIQTAGTVKGRGSSHHAKSDWMEMEKQRGISITTSVMQFPYGGCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDREIRDPMEVLDEVERELNIACSPITWPIGCGKSFKGVYHLHKDETYLYQSGKGHTIQEVRIVKGLNNPDLDVAVGEDLAKQFRQELELVQGASHEFDHEAFLSGDLTPVFFGTALGNFGVDHMLDGLVEWAPAPMPRKTDTRVVVASEEKFTGFVFKIQANMDPKHRDRVAFMRVVSGRFEKGMKLRQVRTKKDVVISDALTFMAGDRSHVEEAYAGDIIGLHNHGTIQIGDTFTQGEDMKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLSNNDLIVGAVGVLQFEVVSSRLKSEYNVEAVYESVNVSTARWVECNDVKKFEEFKRKNELNLALDGGDNLSYIAPTMVNLNITQERYPDVIFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAV2_ECHTE
Sequence: MGLESEKADVQLFMDDDAYSRHSGVDFVEAEKFSASGPDRDPHRLNSHLQLGFQDVIAEPETTHSFDKVWICSHALFEISKYVLYKFLTFFLAIPLAFAAGILFAILSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVVIAPLCTSVGRSFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments (By similarity).
Protein: FOLD_SHIB3
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TGD2_ARATH
Sequence: MIGNPVIQVPSSLMPSSSMIACPRVSPNGVPYLPPKPRTRHLVVRAASNSDAAHGQPSSDGGKNPLTVVLDVPRNIWRQTLKPLSDFGFGKRSIWEGGVGLFIVSGATLLALSWAWLRGFQMRSKFRKYQTVFELSHASGICTGTPVRIRGVTVGTIIRVNPSLKNIEAVAEIEDDKIIIPRNSLVEVNQSGLLMETMIDIMPRNPIPEPSVGPLHPECGKEGLIVCDRQTIKGVQGVSLDELVGIFTRIGREVEAIGVANTYSLAERAASVIEEARPLLKKIQAMAEDAQPLLSEFRDSGLLKEVECLTRSLTQASDDLRKVNSSIMTPENTELIQKSIYTLVYTLKNVESISSDILGFTGDEATRKNLKLLIKSLSRLL
What is the function of this protein?
Component of a phosphatidic acid/lipid transport complex in the chloroplast envelope.  Specifically binds phosphatidic acid (PA).  Involved in lipid transfer from the endoplasmic reticulum (ER) to plastids, and necessary for thylakoids formation.
What are the official names of this protein?
Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic, ABC transporter I family member 15, ABC transporter ABCI.15, AtABCI15.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Single-pass membrane protein.
Protein: PSMD5_BOVIN
Sequence: MAAQALALLREVSRLEAPLEELRALQSLLQSVPLSELREQAAELRLGPLFSLLNENHREQTTLCVSILERLLQALEPVHVARNLRVDLQRGLTHPNDSVKILTLSQVGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKTAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIVEISSVSPESLNCCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLACTHHGRQYLAQEGVIDQISNIIVGADADPFSSFYLPGFVKFFGNLAIMDSPQQICERYPIFMEKVFEMTESQDPTMIGVAVDTIGILGSNVEGKQVLQKTGTRFERLLMKIGYQAKNASTELKIRCLDALSSLFYLPPEQTDDLLRMTESWFSSLSRDPLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVMDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPISTTAVEGAE
What is the function of this protein?
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC).  In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 5.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S5B/HSM3 family.
Protein: RL18_FRATO
Sequence: MDKKTARLSRSKRTRIKLRELGHTRLCVYRTPRHVYAQVISGDGSTVLVAASTVEKDVKAKCKYTGNVESAAIVGEIIADRCKEKGISQVAFDRSGYKYHGRVKALVEAAREHGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TOS6_KLULA
Sequence: MQFSTVISALTLSAVAVFAQETVVSDGVTYVDVTETPEVTVSAVSTELSTSTPYSTTTLAVATLETYAGDNSTSTEHTVEPYSGAALKQEVLGSSLVGVVALVAALL
What are the official names of this protein?
Protein TOS6.
What is the protein family that this protein belongs to?
Belongs to the TOS6 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.