PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_THEVB
Sequence: MITARRVARELALLSAAQVLRQPKLLDESDCRSLILMAVRTLASDVRDTLEQAGTELSESQRLLRHSEFQLPHLEKAQMVLQDALQRAEKGLNKIGAALDLPEILYFAHQEEVQAYAIALLRCLQRYQNEIEELVNRSMVDWQLERLTQLDRAIIEIAVVEMRYLEVAKQVAINEAIELAKRYSDEGSHRFINGVLRRISEALDPAQAATGN
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: YBEY_FRATW
Sequence: MDNLNINFINDDEHPIPSQDLLLKCLQLVADKHHISHAEVNLNIVSNDEIQQINKQFRNKDKPTNIISFKFEKPQGLPDDIANDFLGDIVIAPAVLENEAKEQNKELNDHWQHIFIHGLLHLLGYNHQDDQEAEVMENLEIQLLAQLGIANPYIEQENQNGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_LEIXX
Sequence: MGAGKKIFGIVLAGGEGKRLMPLTTDRAKPAVPFGGQYRLIDFALSNLINSQLRQIVVLTQYKSHSLDRHISQTWRPDGMLNSYIASVPAQQRLGKRWFSGSADAILQSINLLRDEKPDIVVVVGADHVYRMDFGQMIRSHLDSGSSVTVAAIRQPVSLADQFGVIEVDPASPERIAAFREKPSDPVALPESPGEVLASMGNYVFTADALIAAVRRDADRPDSNHDMGGDIIPDFVARGEAGVYDFTNNEVPGSTDRDRYYWRDVGTIDSFFEAHQDLISALPVFNLYNRQWPIFSQVLNSPPAKIVRDGRGALGTTIDSIVSLGSVISGAHLERSVLGPWATVDSGAKVIDSVVFERALIEPNAFVGRAILDKDVVVAAGASIGVDPDRDRARGFTVTESGITVVGKGVHVVP
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MED8_YEAST
Sequence: MSQSTASLVPEGNQGSLQEDVSFDFNGVPGQALDAVRMRLAQLTHSLRRIRDEMSKAELPQWYTLQSQLNVTLSQLVSVTSTLQHFQETLDSTVVYPLPKFPTTSHESLVTTLLRKKNIPEVDEWMKYVRETSGVTTALLKDEEIEKLLQQDREITNWARTTFRNEYGKHDFKNEESLSEEHASLLVRDSKPSKPFNVDDVLKFTFTGEKPIITGSTSTSSSN
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II.  The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.  MED8 binds to the consensus sequence 5'-[AC][AG]GAAAT-3' in both the UAS of SUC2 and the DRS2 of HXK2.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DEAL2_ARATH
Sequence: MARNVGFFICILILAMDVSAGILGIEAEIAQNKVKHLKMWIFECRDPSYTAFKYGLAACILLVLAHVTANFLGGCLCVASRQDLEKSSANKQLAVASLIFTWIILAIAFSMLIVGTMANSRSRKNCGISHHRVLSIGGILCFVHGLFAVAYYISATASTREQTSAGHA
What is the function of this protein?
Involved, partially redundantly with VCC/DEAL1 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
What are the official names of this protein?
Protein DESIGUAL 2.
What is the protein family that this protein belongs to?
Belongs to the DESIGUAL family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ABD12_HUMAN
Sequence: MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
What is the function of this protein?
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283).  Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity).  Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283).  Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063).  Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).
What are the official names of this protein?
Lysophosphatidylserine lipase ABHD12, 2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, hABHD12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12.
What is the protein family that this protein belongs to?
Belongs to the serine esterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PAU23_YEAST
Sequence: MVKLTSIVAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAEYYMFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPADQVTRVITGVPWYSTRLRPAISSALSKDGIYTAVPN
What is the function of this protein?
Component of the cell wall.
What are the official names of this protein?
Seripauperin-23, Cell wall protein DAN2, Delayed anaerobic protein 2.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ZNT6_DANRE
Sequence: MVALDVLGITDSDAPVYRQKQEADTLVLGTIHPFRKAHRSVLGKLAQEFRLVTSDRRSWKILLFGVLNVVCTGCLLMWCSSTNSMALTAYTYLTIFDLFSLITCLLSLWVTMKKPSQIYSFGFQRFEVLAVFSSTVLVQLGSLFILKESVERFVEQPEVHTGRLLVGTFVALFFNLLTLLSVKNKPFVFVSEAASTSWLQEHVADLSRSLCGLIPALSSFLLPRMNPFVLINLAGAFALGITYMLIEINNYNAMDTASAVAIALMTFGTMYPMSVYSGKVLLQTTPSHVIGQLDKLLREVSTLDGVLEVRNEHFWTIGFGSLAGSVHVRIRRDADEQMVLAHVWNRLSALVSALTVHVFKDEWSRASLSSGVLPSAPLSLSEYVTAAAVFPAAPSRAQGSEPTPATSTPAKPSSPPPEFSFHTPGRHVQPVVFQTAHPHRPLYGGLQGPGVRLGLGPRGPTLQAYRTLSAAPHTYTSGTYTGPPRP
What is the function of this protein?
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway.  As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
What are the official names of this protein?
Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles.
Protein: DAPB_TUBMM
Sequence: MYDQVPYRDTDEATPQIKNDASDSNRSSIDTTSTTSLILERLHREDPDDSPGEYESSGPSQRGKPDEDDDLEIGRAARLKPMERKVRRAMYLLAFLMIGGWFLALAVYVSREHFGTPDTAHDPSATATRKAGKKITLNQVMRGAWRSKTHGIQWINGPHGDQDGLLLTQNSFGDGNFLEVQDVKNDSNTIVLIKDGALQGSGQPVSAIKGWPSSDLKKVLVASDHEKRWRHSYNARYWIYDVEKATTEPLVPSEPEARLSLATWSPKGDAIAFVKDNNVFIRQLGLDLTSEYYSVTQVTKDGGPDLFYGIPDWVYEEEVFSGNSALWWSQDGEFLAFLRTNETEVPEYPIQYFVSRPSGNNPPNGLENYPELEFIKYPKAGAPNPVVHLRFYDLKKKEDFAVTVENDFPDDDRLITEVVWSDGKYLLVRETNRESDVLRMVLIDVSARSGKVVREVDISAIDGGWFEVSKNTRYIPADPASGRPYEGYIDTVIHEGYDHLGYFTPLDNKDPILLTKGQWEVVDAPSAVDLKNGIVYFVATEKSPIERHVYSVKLDGSNFRPVTSTSEDGRYDVSFSKLSGYALLTYEGPGIPWQKVVGTPSGDQSFVKDIEKNQGLATLAAKHELPTFHYSTVNIDGFDLHVVERRPPHFNKKRKYPVLFQVYGGPGSQQVSKSFSIDFQAYIAAGLEYIVVTVDGRGTGFIGRKARVAVRGNLGYWEAHDQIETAKIWGKKGYVDKKRIAIWGWSYGGFMTLKTLEQDAGRTFSYGMAVAPVTDWRFYDSIYTERYMHTPQHNQEGYRNATISDTQALSKSVRFLLMHGVADDNVHMQNSLALLDKLDLASVENYDVHVFPDSDHSIYFHNANRMVYDRLEQWLIRAFNGEFLKLDGLKPIREISEPLRKRNRELV
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: PDI14_ARATH
Sequence: MAFRVLLLFSLTALLIFSAVSPSFAASSSDDVDDEDLSFLEDLKEDDVPGADSLSSSTGFDEFEGGEEEDPDMYNDDDDEEGDFSDLGNPDSDPLPTPEIDEKDVVVIKERNFTDVIENNQYVLVEFYAPWCGHCQSLAPEYAAAATELKEDGVVLAKIDATEENELAQEYRVQGFPTLLFFVDGEHKPYTGGRTKETIVTWVKKKIGPGVYNLTTLDDAEKVLTSGNKVVLGYLNSLVGVEHDQLNAASKAEDDVNFYQTVNPDVAKMFHLDPESKRPALVLVKKEEEKISHFDGEFVKSALVSFVSANKLALVSVFTRETAPEIFESAIKKQLLLFVTKNESEKVLTEFQEAAKSFKGKLIFVSVDLDNEDYGKPVAEYFGVSGNGPKLIGYTGNEDPKKYFFDGEIQSDKIKIFGEDFLNDKLKPFYKSDPIPEKNDEDVKIVVGDNFDEIVLDDSKDVLLEVYAPWCGHCQALEPMYNKLAKHLRSIDSLVITKMDGTTNEHPKAKAEGFPTILFFPAGNKTSEPITVDTDRTVVAFYKFLRKHATIPFKLEKPASTESPKTAESTPKVETTETKESPDSTTKSSQSDSKDEL
What is the function of this protein?
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.
What are the official names of this protein?
Protein disulfide isomerase-like 1-4, AtPDIL1-4, Protein disulfide isomerase 2, AtPDI2, Protein disulfide isomerase-like 2-2, AtPDIL2-2.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Golgi apparatus. Vacuole. Nucleus. Secreted, cell wall.
Protein: MOMT1_SOLHA
Sequence: MALSMDNIVISNEEEICMMKAMHLPCGLYLNMVLKAAIELDLFEIIAKSTTQKLSSYEIASQIPTKNPNASSLVLERILRFLASQSLLTCNITKNDDGNVHTTYNLTPLSQSLISDKDGTSIAPFLLLATDPVGVHACFHLKDAILEGEIPFNKAHGVHAFEYHGKDSRMNGLFNKAMQNLTCIEMKRIVECYNGFQGVKEIIDVGGGLGISLASIISKYPNIKGINFDLPHVIKDAPTYEGIEHVGGDMWDSIPQGELIILKAVLHSLDDEDCVKILKNCWRALPNDGKVVVIEQIQPKYPETNLLSKRSFSFDISMMIMFHGGKERTKQQFEDLAKQAGFTYIKVVARAYYSWLIELYKY
What is the function of this protein?
Flavonoid 3'/5'-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as myricetin derivatives, aroma compounds possessing antioxidant properties and exhibiting pharmacological activities such as anti-carcinogen, anti-viral, anti-thrombotic, anti-diabetic, anti-atherosclerotic, and anti-inflammatory effects (PubMed:21343428).  Catalyzes S-adenosylmethionine-dependent regioselective 3'/5'-O-methylation of flavonoids; active on various hydroxylated flavonoid substrates, including myricetin and quercetin, but inactive toward kaempferol (PubMed:21343428).  Mediates the formation of 3'-methyl derivatives from quercetin, myricetin, 3-methyl quercetin and 7-methyl quercetin (rhamnetin), producing 3'-methyl quercetin (isorhamnetin), 3'-methyl myricetin (laricitrin), 3,3'-dimethyl quercetin (3-O-methylisorhamnetin) and 7,3'-dimethyl quercetin (7-O-methylisorhamnetin), respectively (PubMed:21343428).  Triggers the 5'-O-methylation of 3'-methyl myricetin (laricitrin), thus leading to production of 3',5'-dimethyl myricetin (syringetin) (PubMed:21343428).
What are the official names of this protein?
Myricetin 3'/5'-O-methyltransferase 1, ShMOMT1, 3'-methyl myricetin 5'-O-methyltransferase, Syringetin synthase, 3-methyl quercetin 3'-O-methyltransferase, 7-methyl quercetin 3'-O-methyltransferase, Rhamnetin 3'-O-methyltransferase, Myricetin 3'-O-methyltransferase, Laricitrin synthase, Quercetin 3'-O-methyltransferase, Isorhamnetin synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MET_RHIFE
Sequence: MKALAVLGPGLLVHLLTLVQKSGGECKEALVKSAMNVDMKYQLPNFTAETPIQNVVVHQHYIYLGAVNYIYVLNDTDLQKVAEYRTGPVLEHPECLPCQDCSHKANASGGVWADNVNMALLVDTYYDDQLISCGSVRRGTCRRHVLRSDAADIRSEVHCMFSPQADEEPGRCPDCVVSALGTKVLLSEKDRFINFFVGNTISSAHLPGRALHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIVRFCSVDSGLHSYVEMPLECILTEKRRRRSARSEVFNILQAAYVGKPGTHLANQIGVNLDDDILYAVFAQSKPDSAEPMNRSAVCAFPIKLVNEFFNKIVNKNNVRCLQHFYGPNHEPCFNRTLLRIPSGCEVRSDEYRTEFTTALQRVDLFMGQFNRVLLTSVSTFIAGDLTIANLGTSEGRFMQVVVFRSGSSTPHVNFRLDSHPVSPEMIVQHPLNQNGYTLVVTGKTITKIPLNGLGCEHFQSCSQCLSAPPFVQCGWCHNKCVRSEECPSGVWTQDVCHPTIYEVFPTTAPLEGGTTLTICGWDFGFRRNNKFDLKKTRILLGNESCTLTLSESTANTLKCTVGPAMSEHLNLSIIISSGRGTAQYTAFSYVDPIITSVSPSYGPKTGGTLLTLTGKYLNSGNSRHISIGGKTCSLKSVSESVLECYTPAQTTTTEFPIKLKIDLANRETNSFNYREDPIVDEIHPTKSFISGGSTITGVGKNLNSVSGLRMVISVREAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLTTKAFFMLDGIHSKYFDLIYVHDPVFKLFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENVHSHSEAVLCTVPSDLLKLNSELNIEWKQAVSSTILGKVIVQPDQNFTGLIVGVISISVLLSLLFGLFLWLKRRKQIKDLGSELVRYDARIHTPHLDRLVSARSISPTTEMVSNESVDYRATFPEDQFANSSQNGSCRQVQCPLMDLSPILPGGDSDISSPLLQNTVRIDLSALNPELVQAVQHVVIGPSRLIVHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDENFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDHLYEVMLKCWHPKAEQRPSFAELVSRISAIFSAFIGEHYVHVNATYVNVKCVAPYPCLLSSQDHVDGEGDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CT458_HUMAN
Sequence: MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETAFSPKSQQEINADIKRQLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI
What are the official names of this protein?
Cancer/testis antigen family 45 member A8, Cancer/testis antigen 45A8.
What is the protein family that this protein belongs to?
Belongs to the CT45 family.
Protein: SGMR2_RAT
Sequence: MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
What is the function of this protein?
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells.  Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation.  May play a role as a regulator of cellular cholesterol homeostasis.  May function as sterol isomerase.  May alter the activity of some cytochrome P450 proteins.
What are the official names of this protein?
Sigma intracellular receptor 2, Sigma-2 receptor, Sigma2 receptor, Transmembrane protein 97.
What is the protein family that this protein belongs to?
Belongs to the TMEM97/sigma-2 receptor family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
Protein: TRPA_CROS5
Sequence: MTSVSECFQSLRDRKQCGLIPFITAGDPDLETTAKALRVLDASGADLIELGVPYSDPLADGPVIQAAASRALRRGVKLEDVLNIVKGVQGDIKAPIILFSYYNPIFYRGIEAFLEQIKSAGVKGLVVPDLPLEEAETLLKPAAEMGIEVTLLVAPTSPIERIKAIAHQSQGFIYLVSVTGVTGMRTQVATRVEDLLKSLRNTTDKPIGVGFGISEPEHALQVKNWGSDAVIVGSACVKRLAQGTPEEGLKAVGEFCQRLKQAIQ
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DUT_RICPR
Sequence: MTIIEVKIKKLENFLGNLPEYATEHSAGMDLVAANEQSITIKVGSIQLIPTGIAIALPESFEAQIRPRSGLAVKHGITVANSPGTIDADYRGEIKVLLINLGNKDFIIEKGMRIAQMIIAKYERVLWAETSILTETMRGRGGFGSTGL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: CR2_MOUSE
Sequence: MLTWFLFYFSEISCDPPPEVKNARKPYYSLPIVPGTVLRYTCSPSYRLIGEKAIFCISENQVHATWDKAPPICESVNKTISCSDPIVPGGFMNKGSKAPFRHGDSVTFTCKANFTMKGSKTVWCQANEMWGPTALPVCESDFPLECPSLPTIHNGHHTGQHVDQFVAGLSVTYSCEPGYLLTGKKTIKCLSSGDWDGVIPTCKEAQCEHPGKFPNGQVKEPLSLQVGTTVYFSCNEGYQLQGQPSSQCVIVEQKAIWTKKPVCKEILCPPPPPVRNGSHTGSFSENVPYGSTVTYTCDPSPEKGVSFTLIGEKTINCTTGSQKTGIWSGPAPYCVLSTSAVLCLQPKIKRGQILSILKDSYSYNDTVAFSCEPGFTLKGNRSIRCNAHGTWEPPVPVCEKGCQAPPKIINGQKEDSYLLNFDPGTSIRYSCDPGYLLVGEDTIHCTPEGKWTPITPQCTVAECKPVGPHLFKRPQNQFIRTAVNSSCDEGFQLSESAYQLCQGTIPWFIEIRLCKEITCPPPPVIHNGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFKLIGEQTIHCTSDSRGRGSWSSPAPLCKLSLPAVQCTDVHVENGVKLTDNKAPYFYNDSVMFKCDDGYILSGSSQIRCKANNTWDPEKPLCKKEGCEPMRVHGLPDDSHIKLVKRTCQNGYQLTGYTYEKCQNAENGTWFKKIEVCTVILCQPPPKIANGGHTGMMAKHFLYGNEVSYECDEGFYLLGEKSLQCVNDSKGHGSWSGPPPQCLQSSPLTHCPDPEVKHGYKLNKTHSAFSHNDIVHFVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRKASLGCQSPSTIPNGNHTGGSIARFPPGMSVMYSCYQGFLMAGEARLICTHEGTWSQPPPFCKEVNCSFPEDTNGIQKGFQPGKTYRFGATVTLECEDGYTLEGSPQSQCQDDSQWNPPLALCKYRRWSTIPLICGISVGSALIILMSVGFCMILKHRESNYYTKTRPKEGALHLETREVYSIDPYNPAS
What is the function of this protein?
Receptor for complement C3d and for HNRNPU.  Participates in B lymphocytes activation.
What are the official names of this protein?
Complement receptor type 2, Cr2, Complement C3d receptor.
What is the protein family that this protein belongs to?
Belongs to the receptors of complement activation (RCA) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SRP_CHLTA
Sequence: MSTVPVVQGAGSSNSAQDISTSSAPLTLKERISNLLSSTAFKVGLVVIGLLLVIATLIFLVSAASFVNAIYLVAIPAILGCVNICVGILSMEGHCSPERWILCKKVLKTSEDIIDDGQINNSNKVFTDERLNAIDGVVESLSRRNSLVDQTQ
What are the official names of this protein?
Sulfur-rich protein, Cysteine-rich protein A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=Immunolocalizes to the inclusion membrane, the membrane that surrounds the intracellular parasite. This protein is recognized by CD8+ T-cells in both human and mouse infections, suggesting it gains access to the host cytoplasm.
Protein: RL24_VARPS
Sequence: MNKIRKGDQVIVLAGRDKGKRGTVSLRKDDSHLVVEGVNIVKKHAKPNPLKGTTGGIVEKTMPIHQSNVAIFNAATGKADRVGIKITQGADGKRVAVRVFKSSGDEIKFA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: HCST_RAT
Sequence: MAPPGHLLFLFLLPVAASQTNEGSCSGCGPLSLPLLAGLVAADAVMSLLIVGVVFVCMRLHSRPAQEDGRVYINMPGRG
What is the function of this protein?
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation.  Functions as docking site for PI3-kinase PIK3R1 and GRB2.  Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways.  Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells.  In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors.  In T-cells, it provides primarily costimulation for TCR-induced signals.  KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).
What are the official names of this protein?
Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10.
What is the protein family that this protein belongs to?
Belongs to the DAP10 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.