PharMolix/UniProtQA huggingface dataset:
Protein: RS8_CHLT2
Sequence: MGMTSDSIANLLTRIRNALMAEHLYIDIEHSKMLEAIVRILKQHGFVAHFLVKEENRKRLMRVFLRYGEDRRPVIHALKRVSKPSRRVYVSAAKIPYVFGNMGIAVLSTPQGVLEGSVARAKNVGGELLCLVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: F16P2_BOVIN
Sequence: MGDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLANLYGIAGSVNVTGDEVKKLDVLSNALVINMLQSSYSTCVLVSEENKEAIITSKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQPGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGR
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
What are the official names of this protein?
Fructose-1,6-bisphosphatase isozyme 2, FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2, Muscle FBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration. In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase. Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration.
Protein: NSP2_ROTSR
Sequence: MAELACFCYPHLENDSYKFIPFNNLAIKAMLTAKVDKKDMDKFYDSIIYGIAPPPQFKKRYNTNDNSRGMNFETIMFTKVAMLICEALNSLKVTQANVSNVLSRVVSIRHLENLVIRKENPQDILFHSKDLLLKSTLIAIGQSKEIETTITAEGGEIVFQNAAFTMWKLTYLEHQLMPILDQNFIEYKVTLNEDKPISDVHVKELVAELRWQYNKFAVITHGKGHYRIVKYSSVANHADRVYATFKSNVKTGVNNDFNLLDQRIIWQNWYAFTSSMKQGNTLDVCKRLLFQKMKPEKNPFKGLSTDRKMDEVSQVGV
What is the function of this protein?
Participates in replication and packaging of the viral genome.  Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities.  The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures.  The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.
What are the official names of this protein?
Non-structural protein 2, NSP2, NCVP3, Non-structural RNA-binding protein 35, NS35.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP2 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: PDPFB_XENLA
Sequence: MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSVDYSGEVIPHHPGLPKSDPGHWWASFFFGKPTHPVMTTVSESPENSGSFRITSGLVPCGLVQESVLKQKVGDTKSDSSPSA
What is the function of this protein?
Probable regulator of exocrine pancreas development.
What are the official names of this protein?
Pancreatic progenitor cell differentiation and proliferation factor B, Exocrine differentiation and proliferation factor B.
What is the protein family that this protein belongs to?
Belongs to the PPDPF family.
Protein: PUR5_OCEIH
Sequence: MSEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSGTDGVGTKLKLAIDLDKHDTVGIDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIVSGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGIVEKSAMITGKDIKSGDVVIGLSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKGISHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGMAVVVAEEDVSIALQLLEKVDEQAYVIGKVTEEEGVHFTL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAB3_HUMAN
Sequence: MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
What is the function of this protein?
May be an oncogenic factor.
What are the official names of this protein?
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3.
Protein: PACER_BOVIN
Sequence: MVSQSSGRQDSPVDPWEGVSDDPGNTDGLPSLLDTEHPFCPSDIRFTRHRAAWINPPCAQQQLQDASPQVLAVGNRESHTASNTKSPLGTSPLSLGDSVVETSLPKGTTDSLGSSSAWGTAGNGSDSSVTLKEERAGLPRRCPHTSLITSSKTVSGPPCPEDGRAFFKPSQLTASADADAVQVGGRTVSSNSFSPEAFVLPVDAEKENAHFYVADMIISVMEKMKCNILSQQHTETWSTEEAGRSLGNSRADLEGTFYTHVKQESGSSTSSDSGYEGCVLQVSPVVETPTFSEVTEEDCKCDFDDFVIVELGDFSNTTEPCGCSSDTSKSVIHEPNFNSAELIAKELYRVFRKCWMLAEVHYQLTGSLDAAGSIVINEERVQKDFESSTDVVQEIKLKSRIRGTGDWAPPRFQIIFDIHPPLKRDLVVIAQNFFCAGCGTPIEPKFVKRLRYCEYLGKYFCDCCHSYSESCIPARILRMWDFRKYYVSNFSKRLLDHIWHEPIFNLLHVSHGLYTKAKELDRVREIQEQLFHIKKLLKTCRFAESTLKEFEQLPGHLTEALHLFSLEDMVKVKKGLLAPLLKDILKASLEHVASCELCQGKGFICEFCRSTAVIFPFQTATCRRCSACRACFHKQCFQSSKCPRCARITARRRLLESLPSAAT
What is the function of this protein?
Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy.  Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex.  Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes.  Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity).  In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity).  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Protein associated with UVRAG as autophagy enhancer, Pacer, Protein Rubicon-like.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=Associates with late autophagic structure. Recruitment to autophagosome membrane is promoted by autophagic stimuli.
Protein: KDSB_SALPC
Sequence: MSFVVIIPARFSSTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCGFSDDTVIVNVQGDEPMIPAVIIRQVAENLAQRQVGMATLAVPIHSAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAKSLETVGDTCLRHLGIYGYRAGFIRRYVSWQPSPLEHIEMLEQLRVLWYGEKIHVAVAKAVPGTGVDTADDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_RALSO
Sequence: MQKIAGVKGMNDLLPGDAPLWEHFDNAVRSMLRAYGYQQIRTPIVEQTQLFVRGIGEVTDIVEKEMYSFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGPKRLWYTGPMFRHEKPQRGRYRQFHQVGVEALGFAGPDIDAEVILMCQRLWDDLGLVGLKLELNSLGQAEERAAHRADLIKYLEGFQDILDEDSKRRLYTNPLRVLDTKNPALQEMAAGAPKLIDYLGEESCAHFEGVQKLLKANNIPFTINPRLVRGLDYYNLTVFEWTTDKLGAQGTVAGGGRYDPLIEQIGGKPAPACGWAMGVERIIELLREENLAPEPQGSDVYIVHQGDEAQVQALVAAERLRDAGLDVILHASAEGRNGSFKSQFKRADASGAAYAVIIGDDEVASGVVQIKPLRGDPNADAQQTVPSDQLVDRLIDAMVANSD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_STRAW
Sequence: MPYEPPTHTVERSLRATTGAKVIAGVDEVGRGAWAGPVTVCAAITGLRRPPEGLTDSKLLTVKRRTVLAEELRKWVTSYALGHASPEEIDALGMTAALRLAAVRALEALPVRPDAVILDGKHDYLGSPWKVRTVIKGDQSCVAVAAASVIAKVQRDKMMAELGIEHADFGFAANAGYPSPVHKAALAERGPTPYHRLSWAYLDALPQWRHLKKVRSWADGSVPEIEGQLGFDF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_STRA3
Sequence: MFLSIMAGVIAFVLTVIAIPRFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLIVALLVSLIFSIILSKENSGNLGATFGILSVVLIYGIIGFLDDFLKIFKQINEGLTPKQKMSLQLIAGLIFYFVHVLPSGTSAINIFGFYLEVGYLYAFFVLFWVVGFSNAVNLTDGIDGLASISVVISLITYGIIAYNQTQFDILLIIVIMIGALLGFFVFNHKPAKVFMGDVGSLALGAMLAAISIALRQEWTLLFIGFVYVFETSSVMLQVAYFKYTKKKTGVGKRIFRMTPFHHHLELGGVSGKGNKWSEWKVDAFLWAIGIFMSAITLAILYL
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YTCB_ECOLI
Sequence: MHLQLIKDNIHSVVICYT
What are the official names of this protein?
Protein YtcB.
Protein: Y894_MYCTU
Sequence: MPSRATVQEFSDSYPFCHNGFRPIMMPKIVSVQHSTRRHLTSFVGRKAELNDVRRLLSDKRLVTLTGPDGMGKSRLALQIGAQIAHEFTYGRWDCDLATVTDRDCVSISMLNALGLPVQPGLSAIDTLVGVINDARVLLVLDHCEHLLDACAAIIDSLLRSCPRLTILTTSTEAIGLAGELTWRVPPLSLTNDAIELFVDRARRVRSDFAINADTAVTVGEICRRLDGVPLAIELAAARTDTLSPVEILAGLNDRFRLVAGAAGNAVRPEQTLCATVQWSHALLSGPERALLHRLAVFAGGFDLDGAQAVGANDEDFEGYQTLGRFAELVDKAFVVVENNRGRAGYRLLYSVRQYALEKLSESGEADAVLARYRKHLKQPNQVVRAGSGGVRY
What are the official names of this protein?
Uncharacterized protein Rv0894.
Protein: FDHL_STAS1
Sequence: MQEHLIVSLDGKDYLVEPGTNLLQFIKSQDTFVPSICYNESLGPIQTCDTCTVEIDGKMERACSTTIDRPMIVNTQNDKVQASQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDQWGLEHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEVCQDVQVNETLTIDWERQQPRVIWDNDTSINDSSCVGCGQCATVCPCNAMLEVNMEGNAGYMTDLEPGSLAAMIDLTKKAEPGYGPLFAVSDSEAAMREERIEKTKTVCTYCGVGCSFDVWTKNREVLKVQPQHESPANKISSCVKGKFGWDYVDSDERLTKPLVRKNGQFEEVEWEEALSVVAENFNKVKGTHGSDGLAFISSSKATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEIADMVVLIGTNTAEAHPVIASRIKRGHKLYNNTLNVFDIRKHEMAERADNFYQPKPGTDLVWLSAVTKYIIDEDLHDKAFINEWVNHFDEYYKSLAPYTMEFAEETTGISKDALIDFAHQVADAKSVSIAWAMGVTQQDIGSDTSTAISNLLLATGNYRKPGSGAYPLRGHNNVQGCSDMGSMPDQFPGYQKVTDDEIRAKFEREYGETLPKQVGKDNHQMMEGIHNGEIDSLYLYGEDTGIVDSNINFVQAALEKVGFLVVQDEFFTFTATYADVVLPASPSLEKTGTFTNTERRIQRLFQALEPKGDSKPDWQIIQAVAKAMGYDWNYTHPSQIMDEIARLTPLYSGVNYDRLEGYNSLQWPVAEDGTDEPILYLEGFNFEDKKANFYPLTFDNFFKVNEEYDLHVNNGRLLEHFHEGNMTYKVPGLEYKVPNAFVEVSPELAEDRGIHEGAEIKLISETGEVELVAHVTDRVKGKEIYIPLNNNAMAHGDHGAINLLTNSDVDKDTDTPSYKRTSCRMEVKTRRGKSPLNPTNFRVNKQRQPQYSVRVQDKWKREDYTFPGSQVDR
What are the official names of this protein?
Putative formate dehydrogenase SSP0601.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
Protein: GAG2E_HUMAN
Sequence: MSWRGRSTYYWPRPRRYVQPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEAHSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEE
What are the official names of this protein?
G antigen 2E, GAGE-2E.
What is the protein family that this protein belongs to?
Belongs to the GAGE family.
Protein: RLMF_VIBCH
Sequence: MNTPLKPKHGQKTNRKPKANKPVVKKQQTKQPPTHKVQGEEVAAVKSGLHPRNRHRGQYDFPALIKVVPELQSHVMKNPKGQWTINFADPISVKLLNKALLVLHYGVTYWDIPEGFLCPPIPGRADYIHRVADLLLKGNPQLNHSQVRALDIGVGANCIYPIVGVTEYGWSWVGSDVDPVSIQQASLIVQSNSKLQGHIECRLQKNSQHIFNGIIGANERYTVTTCNPPFHASLADAQQGTQRKLTNLQANQRKKGRLATPTLSHSRLNFGGQKAELWCPGGEAAFIGKMAVESQQFAQQVLWFRTLISKGDNVRGMKKQLEKLGAQSIHVIEMAQGQKISRFIAWSFQNAEQRKLWWQAKC
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_TRIV2
Sequence: METKTAKILDGKTLAEKIQKELTAQIIEVQAKIGRPPGLAVLMVGDNPASAAYVRNKEKSCAKVGIASFGKHFPQETSQKELEDVIAALNQDEQVDGILVQLPLPEHLDAVKLLHQIEPDKDADGLHPVNLGRLVRGEKGLRSCTPAGVMRLLAEYEISLRGKQAVVVGRSILVGKPMALMLLEADATVTIAHSRSQDLKSITQNADILVAAAGLPGLITADMVKPGAVVVDVGINRVTDANGKSRLVGDINFASIAGVAEYITPVPGGIGPMTVALLLQNTVTSYLQTAKESGALDVK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ATP6_ECOLU
Sequence: MASENMTPQDYIGHHLNNLQLDLRTFSLVDPHNPPATFWTINIDSMFFSVVLGLLFLVLFRSVAKKATSGVPGKFQTAIELVIGFVNGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMKGIGGFTKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SAP2_ACRMI
Sequence: WSXSGDDDDDDGDSGDDDDDDGDDDSDDDNDADDDSGAEDDNDDDSGDENEDDTDDSGDDVKMIKPTTVMTGWMMTIADESSDDDNERDDTSDDSVGDDAYNDDSQAGELNSDSTYYDQLRSQGDVQSQQGFKNLQSYSNGFKVSSGLVATVVSTLACLFLTNLH
What are the official names of this protein?
Secreted acidic protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: HXNZ_EMENI
Sequence: MDISYPVINAGGLKNIASQIIMEIELDKRENRPTDNVPPDDIGKIEVVDDAEMEQFYGSSTTDAYRLKSELVSQCMADIGMGRFQWKLFTVAGFGWIVDNFCSQGISAVQPPIQQEFSGIKQVSYSSVAYYVGMIIGASFWGISSDLIGRKPAFNSTLAIAGIFLCAAAGTSNFIAFSALWAVIGTAAGGNVVCDSMILLEFIPGSHQYLLTALSGWWNLGQLVVSLLAWVFLANFSCPTDATPDTCSRADNMGWRYTLITLGGLSLAFTFVRIFVFKMPETPRYLLSQGNDQAAVDAVNYVARQNGKPEPLTLSMLQAIDVRLGFTPNAEERLSTKDILKENMQEFRGEHYQALFATRKLSQHTALIWAVWLIIGIAYPLYFNFLPSYLATRFTQDSSLDLTYRNYCIQSAVGVVGPLSAAVLVNTFLGRRWMMGISSIVTGVFLFAYVGVKTPMSSLAFSCVTGLLANFANQLSEYAIMYAFTPESFPAPHRGTASGTAASLLRFGGLVASLIASETGFTTAPIYASAALWVGVGVLCFGLPFETHGHAAI
What is the function of this protein?
Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation (PubMed:29212709).  The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709).  The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
What are the official names of this protein?
Major facilitator-type transporter hxnZ, Nicotinate catabolism cluster protein hxnZ.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SMO2B_XENLA
Sequence: MADDKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLNKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSY
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
What are the official names of this protein?
Small ubiquitin-related modifier 2-B, SUMO-2-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_ESCF3
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWYVDFLAERLRAPLREEPKFFGYTSRINLEGEDVRLLVPTTFMNLSGKAVAAMASFYRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVTEQKLIDEAIDEAARCTEVWFKEGLAKATSRLHTFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFA_PSEAE
Sequence: MTELALILVSAILVNNFVLVQFLGLCPFMGVSRKIETAIGLSLATTFVLTLAAMCSHILQRYVLRPLDLEYLRTIGFILVIAVVVQFTEMLVKKTSPLLYRVLGIFLPLITTNCIVLGVALLNANKAEYGFLQATTQGFGAGLGFSLVLVLFAALRERIAIADVPAPFRGAAIGMITAGLMSLAFMGFSGLVRP
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPT20_YEAST
Sequence: MSANSPTGNDPHVFGIPVNATPSNMGSPGSPVNVPPPMNPAVANVNHPVMRTNSNSNANEGTRTLTREQIQQLQQRQRLLLQQRLLEQQRKQQALQNYEAQFYQMLMTLNKRPKRLYNFVEDADSILKKYEQYLHSFEFHIYENNYKICAPANSRLQQQQKQPELTSDGLILTKNNETLKEFLEYVARGRIPDAIMEVLRDCNIQFYEGNLILQVYDHTNTVDVTPKENKPNLNSSSSPSNNNSTQDNSKIQQPSEPNSGVANTGANTANKKASFKRPRVYRTLLKPNDLTTYYDMMSYADNARFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLEETAFSEPHWDSEKKSFIHEHRAESTREGTKGVVGHIEERDEFPQHSSNYEQLMLIMNERTTTITNSTFAVSLTKNAMEIASSSSNGVRGASSSTSNSASNTRNNSLANGNQVALAAAAAAAAVGSTMGNDNNQFSRLKFIEQWRINKEKRKQQALSANINPTPFNARISMTAPLTPQQQLLQRQQQALEQQQNGGAMKNANKRSGNNATSNNNNNNNNLDKPKVKRPRKNAKKSESGTPAPKKKRMTKKKQSASSTPSSTTMS
What is the function of this protein?
Transcription regulator.  May recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box.  Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).  SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation.  SLIK is proposed to have partly overlapping functions with SAGA.  It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
What are the official names of this protein?
Transcription factor SPT20.
What is the protein family that this protein belongs to?
Belongs to the SPT20 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUPF_RHOCA
Sequence: MCVGIPVQLLAVDGIRGDVIEDGRPGLVDLSLVPEARPGDWVLAFLGAAREVLTPEAAAQISAALGGLRSLMAGGDLGDAFADLEARSPQLPPHLQAALDAGKTRA
What are the official names of this protein?
Hydrogenase expression/formation protein HupF.
What is the protein family that this protein belongs to?
Belongs to the HupF/HypC family.
Protein: PROQ_AERHH
Sequence: MENTEKLKNSKEIVAYLVEKFPACFIAEGEAKPLKIGIFQDLAERLADDARVSKTMLRSALRQYTSSWRYLHGLKAGQARVDLDGNPGELLTEEHIEHAKQALKESKERVFASRRTNTKEEKAKQPRRPAPRKADAAAKSDKPKAAPKAAPVAVEAPLVKVDAATLKVDQGVRVVLGKSPVPATIKEVTKDDVQVQLQTGMMLRVKFEHLVL
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_FRAT1
Sequence: MSKENKTTDFGFTQVPWEEKQKKVAGVFHSVAAKYDLMNDLMSFGIHRIWKKQTIAKSGVRKGDNVLDLAGGTGDLAYKFCQMVGQQGKVILSDINSSMLEVGKEKLTNKGCVGNIEYVQANAECLPFPDNYFDCITISFGLRNVTDKDKALASMCRVLKPGGRSLVLEFSKPIIPLLSKVYDEYSFKALPFLGKIITQDAESYKYLAESIRKHPDQQTLKQMMYDAGFDNVEYQNMTGGIVALHIGYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.