PharMolix/UniProtQA huggingface dataset:
Protein: B2KBE_SICCD
Sequence: IMGHMVNAIEQVDEFLNLGANAIEFDIDFDKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPELREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPLVEDYEFIRAFKDTLKNEGYESYNDKVGINFTGNEDLDKIRDVLEILGIHKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1bxiv, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PTH_ACTP7
Sequence: MSQIKLIVGLANSGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEVRLLVPTTFMNLSGKAVGALANFYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKDIIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQEKINAAVDEAGRCVDLLLKDGITKATNRLNAFKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSDX1_SPHPI
Sequence: MAHFPQTPGFSGTLRPLRIEGDILDIEIEGEVPPQLNGTFHRVHPDAQFPPRFEDDQFFNGDGMVSLFRFHDGKIDFRQRYAQTDKWKVERKAGKSLFGAYRNPLTDDASVQGMIRGTANTNVMVHAGKLYAMKEDSPCLIMDPLTLETEGYTNFDGKLQSQTFCAHPKIDPVTGNLCAFAYGAKGLMTLDMAYIEISPTGKLLKEIPFQNPYYCMMHDFGVTEDYAVFAVMPLLSSWDRLEQRLPFFGFDTTLPCYLGILPRNGDARDLRWFKTGNCFVGHVMNAFNDGTKVHIDMPVSRNNSFPFFDVHGAPFDPVAGQGFLTRWTVDMASNGDSFEKTERLFDRPDEFPRIDERYATRAYRHGWMLILDTEKPYEAPGGAFYALTNTLGHIDLATGKSSSWWAGPRCAIQEPCFIPRSPDAPEGDGYVIALVDDHVANYSDLAIFDAQHVDQGPIARAKLPVRIRQGLHGNWADASRLAVAA
What is the function of this protein?
Catalyzes the cleavage of the interphenyl double bond (C alpha-C beta) of lignin-derived polyphenolic diaryl-propane type compounds (Stilbene).
What are the official names of this protein?
Lignostilbene-alpha,beta-dioxygenase isozyme I, LSD-I.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: VLDLR_HUMAN
Sequence: MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
What is the function of this protein?
(Microbial infection) Acts as a receptor for Semliki Forest virus.
What are the official names of this protein?
Very low-density lipoprotein receptor, VLDL receptor, VLDL-R.
Protein: DEF_STAAM
Sequence: MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LPXC_SHESH
Sequence: MIFQRTVKEMVKTTGVGLHSGNKVTLSIKPAPVNTGIVLVRTDLEPAVAIPAKADLVRETTMCTALVNDEGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPWVFLLQSVGIQEQASAKKYLRIKNTVRVEDGDKWAELKPFKGFRVDFAIDFNHPEIARSQQHMVMDFSTSAFVRDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKILDAFGDLYVAGYAIVGEFCAFKTGHALNNQLVRALLAQQDAWELVSFEKDEAPVSFSVPTGAAVFT
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RF1_CLOBL
Sequence: MLERLNFIENKYEELSNKISDPSVMANQKEWQKLCKEHADLEIIVNTYREYKKAQEDLESDKEMLKEESDKELREMAQEEIKELTLKLEDLERELTILLLPKDPNDDKDVFIEIRAGAGGEEAALFASNLLRMYTRYAERKNWKVETMSLNATDIGGFKEVTVAIKGKGAYSRLKYESGVHRVQRVPDTESSGRIHTSTATVAVLPEVDDVDININANDLRIDVYRASGHGGQCVNTTDSAVRITHLPTGLVVTCQDEKSQLKNKEKAMKVLKARLFEAAEAERAASIAEDRKSQVGTGDRSERIRTYNYPQGRITDHRIGLTLYKLETFLDGDIDEVIEALVTEDQAEKMKDLGRVN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDBH2_TITSE
Sequence: AEIDFSGIPEDIIKEIKETNAKPPA
What is the function of this protein?
Agonist of the B2 bradykinin receptor (BDKRB2).  Potentiates the hypotensive effect of bradykinin (BK) and induces a direct vasorelaxing effect, independently of BK, by endothelium- and nitric oxide (NO)-dependent mechanisms in rat aortic ring preparations.  Does not inhibit the angiotensin-converting enzyme (ACE).
What are the official names of this protein?
Hypotensin-2, Hypotensin II, TsHpt-II, Toxin Ts14 2.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PDE1A_MOUSE
Sequence: MGSTDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKSQSSNYGASSSSTMIGFHVADSLRRSNTKGSVCDGSYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEELGNTEEKHADTRP
What is the function of this protein?
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes.  Has a higher efficiency with cGMP compared to cAMP.
What are the official names of this protein?
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Cam-PDE 1A, 61 kDa Cam-PDE.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
What are the subcellular locations of this protein?
[Isoform 2]: Cell projection, cilium, flagellum. Note=Concentrates in the tail of mature sperm.
Protein: RIBA_PSEPG
Sequence: MPVVFVAASKLPTPFATFTMHGFLDEATGREHVVLSLGDIADGQPVLGRLHSECLTGDALFSQRCDCGSQLEAALQAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSLRLMTNNPRKVKALTDMNIVVAERVPLHTGHNPHNRYYLATKAGKLGHMLGNEHQGEAPQA
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: DNAA_ACIAD
Sequence: MLWTDCLTRLRQELSDNVFAMWIRPLVAEETTDSLRLYAPNPYWTRYIQEHHLELISILVEQLSEGRIRQVEILVDSRPGAILSPAEQPATTTAALSSTPVVPQRVKKEVVEPAATQSNKILNSKKRLLNPLFTFSLFVEGRSNQMAAETCRKVLTQLGASQHNPLFLYGPTGLGKTHLMQAVGNALLQAKPNARVMYMTAESFVQDFVSSLQKGKVEEFKKNCRSLDLLLVDDIHLLAGKEASLVEFFYTFNALLDESKQIILTSDRYPKELTELDPRLVSRFSWGLSVGVEPPDIETRIEILLKKAENSGVDLPRNCALFIAQQVVANVRELEGALNKVVAIARFKGSQIDLDVVRESLKDVLAIRARTISVENIQRVVSEYFRIPLKELIGPKRTRIYARPRQLAMGLARELTGDSFPEIGMAFGGRDHSTVMHACEKVQSLKQEDPIFNEDYKNLLRLLQS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURF_MYCTO
Sequence: MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLRLPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEEAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGDVVLVKASNAAGLGAVADALVADDTCGSVRP
What is the function of this protein?
Involved in cell wall formation.  Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
What are the official names of this protein?
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase, D-alanyl-D-alanine-adding enzyme, UDP-MurNAc-pentapeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_PROA2
Sequence: MSMFIRKEIDLGSGKTLSIETGKMAKQADGSAIVRLNDTMVLATVVSSKTPPSPNQSFFPLQVEYREKYSAAGKFPGGFFKREGRPSEKEILSARLIDRALRPLFPDGYYQDTQIIISVISSDQINDADVLGGVAASAAIMVSDIPFQNSMSEVRVGRVNGEYIVNPNINELRDSDIDISIGGTENTICMLEGEMDEISEAEMLEAIRFGHEAIKKICALQNEIAAEVGKTARTFSAAKAPDNLRQSIAEICSNELKELAYMPLCKEERAEKTAEIYKNAKAQTLQRYQQEITPEVIAAEPEKALYLNEQIIGDAIHSIEKQVMREMILDDAKRLDGRRLDEVRPISIELGLIPRAHGSALFTRGETQALVTLTLGTKKDAQMIDTLTDDADKRFMLHYNFPPFSVGETGRVGGTSRREIGHGNLAERAIRKVAPAESAFPYTIRIVSDILESNGSSSMASVCGGALAAMDGGVPLRKPVSGIAMGLIKEGDRYAVLSDILGNEDHLGDMDFKVAGTADGITACQMDIKIDGLDYHILEQALEQALHGRLHILDKMNEAIQEPRTEIGKYAPKLTTIQIPVDAIGMVIGKGGETIRSITEETGAEINIEDDGTVTIASASGEGASAALETIKLLISKPEVGTVYSGKVRDIREDLGAFVEFLPKTDGLVHISEISNERVAKVSDHLKPGDKVKVKLVDVRKDPRTGKTRFALSIKALAEKSADNGASDKAEANR
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDA5_YEAST
Sequence: MNIDCLCRWVVLPLLRYPLLVALVLRWSLSDSISICLTIYTLLINAFLIANSYIKRSGQVAWKSLREFKNGIVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNTRVKDLICDLSDDEEVAALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKIFKINTFAPLQFIQELAPSRHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYSFELQNEGVRNIRTLLVTPGQLNTEMFAGFKPPRQFFAPVIDITTLAAKIVRYCELGQRGQLNEPFYCSFAHLLMCVPYSLQRIVRSFSRIDCCLPDE
What is the function of this protein?
Involved in the resistance to DNA-damaging agents.
What are the official names of this protein?
Uncharacterized oxidoreductase TDA5, Topoisomerase I damage affected protein 5.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ALR_SYNFM
Sequence: MAHSWVEIDLAALRHNYSRAKERLAPGSRILGVVKSDAYGHGMIPVARELVACGASFLAVSKHWEAVDLRAAGIRLPILCLLGVEPSEMAEAIRNEIRPVIYRIDHARRLSDTARSLNATATVHVKLDTGMGRLGIPCRHLEAFLNELLTLPAIRLEGVLSHFASADEADKTSSTLQLTRFREAMALLSARGLSVLGHIANSAGLLDLPQAHFDLARPGIMLYGSPPSLELHKPADLRPVMTFKSKIIQLKDVQAGQPIGYGGTFVTAAPGRIATIPVGYDDGYPRLLSNRGRVLVRGMSAPVVGRVSMNMITADVTHIPSAREDDEVVLLGAQGTERVTAEEIAQLCGTISYEIYCSIGRNRFKSFHNGIANSN
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: ABRAL_BOVIN
Sequence: MNVDHEVKLLVEEIHRLGSKNADGKLSVKFGVLFQDDKCANLFEALVGTLKAAKRRKIITYSGELLLQGVHDDVDIILLQD
What are the official names of this protein?
Costars family protein ABRACL, ABRA C-terminal-like protein.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: MURB_CHLTA
Sequence: MTDSFPFSVQESVPLSRFSTFRIGGPARYFKELTSVSEALTVFSYLHTHPLPYIIIGKGSNCLFDDQGFDGLVLYNNIQGQEFLSDTQIKVLSGSSFALLGKRLSSQGFSGLEFAVGIPGTVGGAVFMNAGTTLANTASSLINVEIIDHSGILLSIPREKLLFSYRTSPFQKKPAFIASATFQLTKDPQAAKRAKALIEERILKQPYEYPSAGCIFRNPEGLSAGALIDRAGLKGLKIGGGQISEKHGNFIINTGNACTADILELIEIIQKTLKKQGISLHKEVRIIPFRL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10E_PYRAR
Sequence: MPVRPARCYRRIKGPPYTREEYIHGAPMIQIPKFDMGTTSAAARATFPMVAKLIVEERGQIRMQALEAARQMASKYLTKYVGDANYYLRLNVIPHHVLRENRMLAMAGADRLQEGMRLAFGSPAGRAARVEPGQILFYAEFKPEHLAHIKEAFRRAASKLPLPTRIVIEPKGDGDGKTATQG
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CAZA1_RAT
Sequence: MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEDVDGGLKSWRDSCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEVQTAKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  May play a role in the formation of epithelial cell junctions (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-1, CapZ alpha-1.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ADDA_BACCZ
Sequence: MMENWPKKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPGSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRYTSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGKTIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPDGPAPRVETLQADLALLGTLSSAARESWTSVYEAMQNVSWQTLKRIKKSDYNEDIVKQVDSLRNKAKDEVKKLQEELFSRRPESFLRDFQDMHPVLEKLVQLVKVFTGRFQAMKRDKGMVDFTDLEHFCLQILSEQSEDGEMKPSAVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGASYPEGEDVAAELLCIQQTEEEVIDGEEGAEVEKAQLEARLMAQRIKAMVDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMSSFLKGAPLEEEKELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKEKLILIGTVKDANKEMEKWLDAREHSEWLLPDHIRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEVVDGNTLLAPEPVQEEKQELLEALREKKAVPLESERKEEVYDRLMWKYGYEEATSHRAKQSVTEIKRNYQSEEGSDNAFIKKLRAPIRTRPRFMEKKGLTYAERGTAVHAVMQHVDLKKPVTVEVLQEQIAGMVNKELLTFEQAEEIAIEKVISFFDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGESGESILVQGVIDCMIEEEDGITLIDFKTDTIEGKFPGGFDQAKPILEVRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKVEE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: KKA4_NIACI
Sequence: MNESTRNWPEELLELLGQTELTVNKIGYSGDHVYHVKEYRGTPAFLKIAPSVWWRTLRPEIEALAWLDGKLPVPKILYTAEHGGMDYLLMEALGGKDGSHETIQAKRKLFVKLYAEGLRSVHGLDIRECPLSNGLEKKLRDAKRIVDESLVDPADIKEEYDCTPEELYGLLLESKPVTEDLVFAHGDYCAPNLIIDGEKLSGFIDLGRAGVADRYQDISLAIRSLRHDYGDDRYKALFLELYGLDGLDEDKVRYYIRLDEFF
What is the function of this protein?
Resistance to butirosin and structurally-related aminoglycosides, including kanamycin and amikacin.
What are the official names of this protein?
Aminoglycoside 3'-phosphotransferase, APH(3')IV, Butirosin resistance protein A, Kanamycin kinase, type IV, Neomycin-kanamycin phosphotransferase type IV.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_CRUWA
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HSLU_SALEP
Sequence: MSEMTPREIVSELNKHIIGQDNAKRSVAIALRNRWRRMQLDEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQAEQQQEPSAARQTFRKKLREGQLDDKEIEINLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKPRKLKIKDAMKLLVEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGETSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASVTVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNETTENIGARRLHTVLERLMEEISYNASDLHGQNITIDAEYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEM1B_CHICK
Sequence: MEGLAGYVYKAASEGRVLTLAALLLNRSESDIKYLLGYVSQHGGQRSTPLIIAARNGHTKVVRLLLEHYRVQTQQTGTVRFDGFVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQHADPNAKAHCGATALHFAAEAGHLEIVRELVKWKAAMMVNGHGMTPLKVAAESCKADVVELLLAHAGCNRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERYRDSENIIEKEVLPPIEAYGNRTECRTPQELESIRQDRDALHMEGLIVRERILGSDNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNEPVKAKDIESVLRCSVLEIEQGMSRIKATQDDDIHTAVDNYECNIFTFLYLVCISTKTQCSEEDQSRINKQIYNLIHLDPRTRDGSTLLHHAVNSSTPVDDFHTNDVCSFPNALVTKLLLDCGADVNAVDNEGNSPLHLIVQYHRPISDFLTLHSIIISLVEAGAHTDMTNKQKKTPLDKSTTGVSEILLKTQMKLSLKCLAARAVRIYNISYQNQIPRTLEEFVKFH
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, leading to their ubiquitination and degradation.
What are the official names of this protein?
Protein fem-1 homolog B, FEM1b, FEM1-beta.
What is the protein family that this protein belongs to?
Belongs to the fem-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PHAB_SYNY3
Sequence: MLSLGLEDKVIVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNTEALGVVANVTDLESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAYSIKPFIEGMYERKAGSIVAISSISGERGNVGQTNYSATKAGVIGMMKSLAREGARYGVRANAVAPGFIDTEMTLAIREDIREKITKEIPFRRFGKPEEIAWAVAFLLSPVASSYVTGEVLRVNGAHHT
What is the function of this protein?
Catalyzes the reduction of acetoacetyl-CoA to (R)-3-hydroxybutyryl-CoA (PubMed:26358291).  When expressed in E. coli with Synechocystis PhaA, PhaC and PhaE confers the ability to synthesize up to 12% (w/w) poly(3-hydroxybutyrate) (PHB) depending on the carbon source (PubMed:11010896).
What are the official names of this protein?
Acetoacetyl-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UPK1B_HUMAN
Sequence: MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
What are the official names of this protein?
Uroplakin-1b, UP1b, Tetraspanin-20, Tspan-20, Uroplakin Ib, UPIb.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.