PharMolix/UniProtQA huggingface dataset:
Protein: RL31_RICTY
Sequence: MKNGIHPEYKKLLIKVGSNIFETMSTHPIGEILMDVDFRKHPAWNKDSGNVVNQSNKSVSDFNKRFSGLSFDSKKEAS
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: CYPLE_PSYLE
Sequence: SVTPIVCGETCFGGTCNTPGCSCSWPICTK
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide psyleio E.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: TSAC_PHOPR
Sequence: MDNLQQVVSALQSGEVIAYPTEGVFGVGCDPDNPQAVEKLLALKQRPIEKGLILIAANYQQLQPYIDDAQLSDLQKQKIFSTWPGPVTWVMPVKKDISPLLTGKFTSIAVRVSDHPLVQKLCHQFGKPITSTSANLTGLPPCKTVTEVQNQLGEHLSAILEGETGGRENPTEIRDAFSDTVLRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_CLOTE
Sequence: MLEIKVPGTSANFGPGFDSLGVALSIYNKFYVEEIESGIYIEGCEEKYRNDKNLFYVSMKKVFDKFGYKLKGLRIKIEGDIPESRGLGSSASCIVGGVMAANDFIGNKLSKEEMLEISTEIEGHPDNVAPAIFGGMTAVVKDKDRIYHDKIDIDKNINFHALIPNFILSTKKSREVLPKTVDYKDAVFNVGRVALMISSLISGKYENLEVAFEDKLHQPYRKELIGNYDDLIVKCKKNGALGVFLSGAGPTIMAITEKHREDFLKNMNEELRILNHKWNIKKLVVDHKGATVISKLNGGI
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MODC_RHILO
Sequence: MSVRVDIGHRLGDFAVEARFESAGRLTALFGPSGSGKTTLINMIAGLIRPDKGCIEVEGRVLVDTDAGIFVPKHRRRIGMVFQDARLFPHMSVASNLRYGRWFTPAKERYADMDAVIDLLGIGPLLGRRPAKLSGGEKQRVAIGRALLASPGLLLMDEPLASLDEARKAEILPYIERLRDETKIPIVYVSHSVAEVARLASDVVMLAQGKVVASGPTEAVMQRLDLLPAEERGEGGAVLDTKVLRHDEAFGMTVLGSAAGEIRVPRLAMQTGAPVRVRIRARDVMIATEKPTGLSALNILPGTIVAISPGEGPAVEVGIDCNGATVLARITEQSRQALELRLGGNVFAVVKTVSFDRANTGAGLPLEVDG
What is the function of this protein?
Part of the ABC transporter complex ModABC involved in molybdenum import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Molybdenum import ATP-binding protein ModC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNFE_BUCAI
Sequence: MNIKSFLNNRLWKNNSSLVQLLGLCPVLAMTTNAINAIGLGMTTTLVLTITNTIISSFRKIIPKDLRIPIYMMIISSVVTSIEMLLHAYTFNLYQSLGIFIPLIVTNCIIVGRADLIAYKSSIVESFFDGIFIGLGSMFAMFAVGSIREILGNGTLFFGANKIISNIHSSVFFTLLDKKFTIILAVFPPGGFLILGFLIAIKNFIDLYYKKNTIKNIEQCSCSNKIK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MP_BCTVC
Sequence: MMVCLPDWLFLLFIFSILLQSGTNFYGTFQSGSISRQLSSLSSSIDQLFLKVQQVVYTRYPSRDRVSDPRRRRGLSSIPEGSEEATEV
What is the function of this protein?
Probably involved in the viral transport within, and between cells.
What are the official names of this protein?
Movement protein, MP.
Protein: PRIC3_MOUSE
Sequence: MFARGSRRRRSGRAPPEAEDPARGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVRTVPVDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRATVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHAGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMGHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCSRPLLGRPFLPRRGLIFCSRACSLGSETTAPGPGRRSWSAGTVTTPLTTSTASFSATEGTSETASKGTCTKAEPAAGPEEPSHFLRGAPHRHSMPELGLRSAPEPPTESPGHPAPHPDDNAFGRQSTPRVSFRDPLVSEGGPRRTLSAPPAQRRRPRSPPPRTPSCHHHHHHRRRRQRHRRRGSHHHHHHPGRHGHHRCDLGSGSDSGSCSSSPSSPSSESSEDDGFFLGERIPLPPHLCRPRTTQDTSTETFNSPAQPLVQESHPVMPRQTRDKNCIVA
What is the function of this protein?
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity).  PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity).  Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity).  Involved in the organization of the basal body (By similarity).  Involved in cilia growth and positioning (By similarity).  Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135).
What are the official names of this protein?
Prickle planar cell polarity protein 3, LIM domain only protein 6, LMO-6, Prickle-like protein 3, Pk3, Triple LIM domain protein 6.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity).
Protein: STAR6_MOUSE
Sequence: MDYKAIAQQTAEQVLAYNQDLSGWKLIKSSKKVTVSSKTSRIFHGNLYRVEGIIPESAAHLSDFLFKHDHRVSWDKSLKGFNVIHKIDSDTLICHTITQSFAMGSISPRDFIDLVHIKHYERNVDIISTKSVDFPGYAPTSTYIRGFNHPSGYVCSPLKENPAYSKLVIFVQTEMKGKLPASVIEKSMPSNLVSFLLNVKDGVKTYRIPPIRARHSSHSSVHKKKEGHSAIKP
What is the function of this protein?
May be involved in the intracellular transport of sterols or other lipids.  May bind cholesterol or other sterols (By similarity).
What are the official names of this protein?
StAR-related lipid transfer protein 6, START domain-containing protein 6, StARD6.
Protein: KAE1B_METLZ
Sequence: MPEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKALDEAGEKIDAVAFSIGPGLGPSLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKFADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDKFARSHNLPHPGGPIIEKMAKDGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAHTGKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGSTIPIAESVVNPGFRSDQVEVTWRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAKGYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVTDHEIVMEKLDGDVLKYVMNEEYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLFQTLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_CLOAB
Sequence: MEQLCKRILEEGKALNEYVLKVDSFLNHNVDPKLMYEIGTYFKEYFSARGITKIFTIESSGIAPAVMTALQMDIPMVILKKQKPNTLTEDVYQTTVHSFTKGSDYELTLLKKYISDKDKILIIDDFLANGEASLGAVRLVETAGAEVSGIGIVIEKSFQKGRKCLEEKGYDIYSLARIKKLGKDLIEFL
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAG29_DERFA
Sequence: KDDIERMVKEAESYKEEDDKQRDRIAAKNSLEGYAFQMKATLDEEAIKSKVSEEDRKKILDKVDEVLKWLDANALAEKDEFEHQRKELESVCNPIITKLYQQAGGAGAGGMPGGFPGGFPGTDGSGGGAAGGDGGKSGPTIEEVD
What are the official names of this protein?
Allergen MAG29.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: UPP_ECO7I
Sequence: MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MTRD_METJA
Sequence: MDIVSAIVPLIEMTIAGAIINASVHFIPVGGAPAAMATSTGVGTGTTQLAAGAGFTGLMGAAVMASNVGLSPIGMALIMISGAVSSMIMLGVTMLIGQLIYVFGVGVVPAADKCEIDPITKDPQKPYVTPGTTGHGVPTVCFVSGLIGAALGGIGGALAYIALRKLGLDPGVAGMLAVGFFFINAVLASYNIGGTIEGFHDPKFKKMPNGVIASTVASLLFGIISVLMVL
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit D, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D.
What is the protein family that this protein belongs to?
Belongs to the MtrD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FDH2_YEASC
Sequence: MSKGKVLLVLYEGGKHAEEQEKLLGCIENELGIRNFIEEQGYELVTTIDKDPEPTSTVDRELKDAEIVITTPFFPAYISRNRIAEAPNLKLCVTAGVGSDHVDLEAANERKITVTEVTGSNVVSVAEHVMATILVLIRNYNGGHQQAINGEWDIAGVAKNEYDLEDKIISTVGAGRIGYRVLERLVAFNPKKLLYYDYQELPAEAINRLNEASKLFNGRGDIVQRVEKLEDMVAQSDVVTINCPLHKDSRGLFNKKLISHMKDGAYLVNTARGAICVAEDVAEAVKSGKLAGYGGDVWDKQPAPKDHPWRTMDNKDHVGNAMTVHISGTSLHAQKRYAQGVKNILNSYFSKKFDYRPQDIIVQNGSYATRAYGQKK
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide.  Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms.  Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
What are the official names of this protein?
Formate dehydrogenase 2, FDH 2, NAD-dependent formate dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_AGRRK
Sequence: MLDIKWIRENAEVLDAALAKRGAEPLSQGLIALDEKRRSIIQSVQDMQSRRNAASKEIGAAMAQKNTELAEKLKGEVADIKTSLPAAEEEERVLTAELNDALSRIPNIPLDDVPVGKDEHDNVVKHSWGAKPAWNHKPKEHYEIGEELGYMDFERAAKLSGSRFTVLTSQLARLERALGQFMLDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDSFRTTGGHWLIPTAEVTLTNLVSGDILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESSIAEHERMTACAEEVLKRLGLHYRVMTLSTGDMGFGARKTYDLEVWLPGQDTYREISSCSVCGDFQARRMNARYRGKDDKGTKFVHTLNGSGTAVGRCLIAVLENYLNDDGSVTVPDALLPYMGGLKRIERAA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MP2K7_MOUSE
Sequence: MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPTRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYEILEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSTSVTWGAWPLAAQTPFQSGVIRCRGRVPSPRRATGGSGGQPCVCAGGPGPSFTEMGPSPSPMLSNTFFTPDPGACPGASTWGLPRRRLCQLLTTSTPGCC
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.  MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif.  MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue.  The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation.  Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines.  The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.  Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL6_VIBC1
Sequence: MSRVAKAPVAIPAGVEVKLNGQEITVKGAKGELTRVLNDAVVIAQEENNLTFGPKEGAANAWAQAGTARALVNNMVVGVTEGFTKKLTLKGVGYRAAIKGNAVGLTLGFSHPVEHELPAGIKAECPSQTEIIITGCDKQLVGQVAADIRSYRQPEPYKGKGVRYADENVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RIMM_CARHZ
Sequence: MNNLIAIGYVLGTFGIEGWVKVEPLTDHPQRFLNTERVFWEKEDEIFPLRIEEVQLQAERILVKFMEINDIKEANKLIFGYLKIPKNEIVQLKENEFYLFQLKGLTVYDLNYQKIGVVRTVLKNPANDLLVIDTIHDKELLLPFIKVFVKEVNLPEGFIKVELLPGMLEEKK
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_STAEQ
Sequence: MDKEKGLLIVLSGPSGVGKGTVRKKIFEDPTTSYKYSISMTTRHMREGEIDGVDYFFKTKEEFEALIKDDQFIEYAQYVGNYYGTPVQYVKDTMEEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDDLRERLVGRGTESDEKIQSRVNEARKEVEMMNLYDYVVVNDEVELAKNRIQSIVEAEHLKRERIEAKYRKMLLEVKK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA1S1_CONPL
Sequence: MRCLAFLVVTLLLFTATATTGASNGMNAAASGEAPDSISLAVRDDCCPDPACRQNHPELCSTR
What is the function of this protein?
Alpha-conopeptides-like may act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like PuSG1.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DEF1_XANCP
Sequence: MIREIIRMGDKRLLRVAPPVTNLGSDELHALVADMFETMDAARGVGLAAPQIAVDLQLMVFGFEASERYPEAPAVPRTALANVQIEPLSDEMENGWEGCLSIPGLRAVIPRHRVIRYSGFAPDGTPIEREAEGFHARVVQHEYDHLVGRLYPSRIENFDTFGFEDVLSYDL
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 1, PDF 1, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RLMG_VIBA3
Sequence: MKTELTLLDRTLTLHRFPNRSNETLQAWDAGDEYIISHVEEMNLEPGKHILIMNDSFGALSAWFSKDHDVTMMSDSFISHRGALKNLQRNQSNRVNFLNTMDDIPHGIDLVIMQLPKTNRHLVWQLSQLRQALPEGCQVIGVNKVKDIHTSTLNIFEKYLGETKTSLAKKKHRLVFSSPNCQPIQTVEPFVEWDVDGEDIRLKNLPNVYSGEALDQGARYMLEHIPQDPELRHIIDLGCGNGVLSVKAGQLNPQARITCVDESFMAVESARQNIKDNLGEEGNFQFIANNCLDGFKKNSTYLVMCNPPFHQQQAITDHIAWQMFCDAKHVLSNGGKLIVIGNRHLGYDVKLARLFGEANVETLELNQKFEILQATREPANFNK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_MAIZE
Sequence: MATACPPLSLPSTSLFRGRSARAGPNAGSSRPSAAAPSERRSWRRPRPDGGRAAAGERNQREEVERPPVWLMRQAGRYMKSYQLLCERYPSFRERSENVDLVVEISLQPWKVFKPDGVILFSDILTPLPGMNIPFDIVKGKGPVIYDPLRTAAAVNEVREFVPEEWVPYVGQALNILRQEVKNEAAVLGFVGAPFTLASYCVEGGSSKNFTLIKKMAFSEPAILHNLLQKFTTSMANYIKYQADNGAQAVQIFDSWATELSPADFEEFSLPYLKQIVDSVRETHPDLPLILYASGSGGLLERLPLTGVDVVSLDWTVDMAEGRKRLGSNTAVQGNVDPGVLFGSKEFITRRIYDTVQKAGNVGHVLNLGHGIKVGTPEENVAHFFEVAKGIRY
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, chloroplastic, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: M2K8_ARATH
Sequence: MVMVRDNQFLNLKLSPIQAPTTIPPCRFPIIPATKVSATVSSCASNTFSVANLDRISVLGSGNGGTVFKVKDKTTSEIYALKKVKENWDSTSLREIEILRMVNSPYVAKCHDIFQNPSGEVSILMDYMDLGSLESLRGVTEKQLALMSRQVLEGKNYLHEHKIVHRDIKPANLLRSSKEEVKIADFGVSKIVVRSLNKCNSFVGTFAYMSPERLDSEADGVTEEDKSNVYAGDIWSFGLTMLEILVGYYPMLPDQAAIVCAVCFGEPPKAPEECSDDLKSFMDCCLRKKASERWTASQLLNHPFLLHQD
What are the official names of this protein?
Mitogen-activated protein kinase kinase 8, AtMKK8, MAP kinase kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: MPAF2_PENBR
Sequence: MVEILDYTKALEVLKEYPSGDGLHVDTLLDSDNHGALTYNDFLILPGSITFSAADVSLDTKVTRRFTIKAPLLSSPMDTVTEHNMAIHMALLGGLGVIHNNCPPDDQAEMVRKVKRYENGFILDPVVLSPSTTVAEAKELKTKWNFGGFPVTGKTHYLSSFGKLASSDSFSLLEKGTLHSKLLGIVTSRDIQFHKTPEDPVTAVMSTELVTAPAGTTLAEANEVLRSSKKGKLPIVDKDGLLVSLLSRSDLMKNIHYPLASKLPSKQLLCAAAISTHDADKVRLQKLVDAGLDIVVVDSSQGNSMYQIAMIKWIKSTFPDIDIIAGNIVTREQAAALIAAGADGLRIGMGSGSACITQEVMAVGRPQAASVRSVSAFAARFGVPTIADGGVQNLGHIVKGLALGASAVMMGSLLAGTTESPGEYYVSNEGQLVKAFRGMGSIAVMEDKGKSGGGKNAGASRYFSENDKVKVAQGVAGSVVDRGSITQYVPYLVAGIQHSLQDIGVQDLEALHNGVNNGQVRFEMRSASAQTEGNVHGLHSHEKKLYSS
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).  Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world (By similarity).  Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases (By similarity).
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH, Mycophenolic acid biosynthesis cluster protein F'.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_HELPG
Sequence: MLICNDKFNPKTLLEEIMALRPWRKGPFEISQIKIDSEWDSSIKWDLVKNATPLKDKVVADVGCNNGYYLFKMLEHGPKSLVGFDPGVLVKKQFEFLAPFFDKEKKIIYESLGVEDLHEKYSNAFDVIFCLGVLYHRKSPLEALKALYHALKIRGELVLDTLIIDSPLDIALCPKKTYAKMKNVYFIPSVSALKGWCERVGFENFEVLSVLKTTPKEQRKTDFILGQSLEDFLDKTDHSKTLEGYDAPLRGYFKMLKPSKR
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.