PharMolix/UniProtQA huggingface dataset:
Protein: CLPP2_GLOVI
Sequence: MSELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYLESEDNAKPIEIYINSPGVAGFETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTKGQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRTLNQLLSIHTGKTVEQIDKDTERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA2D1_RAT
Sequence: MAAGCLLALTLTLFQSWLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESESGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFAADRLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFTFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYRYLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPRMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITDILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLW
What is the function of this protein?
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity).  Plays an important role in excitation-contraction coupling (By similarity).
What are the official names of this protein?
Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel subunit alpha-2/delta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GLPA1_HALVD
Sequence: MKKSPSVLVIGGGSTGTGIARDLAMRGLDVTLVEKGNLTHGTTGRMHGLLHSGGRYAVSDQPSAKECIEENRVLRRIAGHCVEMTGGLFVQRPEDSDEYFEKKLEGCRECGIPAEVLSAEEAREIEPYLAKDIKRAIKVPDGAVDPFRLCVANAASAVEHGARIETHSEVTDVLVEGGEVVGVEVTHQTGTGPYVHGEPGEVEEIRADYVVNATGAWAGQIGDFAGVNVEVRPSKGVMTIMNTRQVDTVVNRCRPKGDADIIVPHETTCILGTTDEEVEDPEDYPEEGWEVDLMIETLSELVPMLADARTIRSFWGVRPLYEPPGTGTEDPTDITREFFLLDHADRDDLPGMTSIVGGKLTTYRMMAEQISDHVCEKLGVDAECRTADEPLPGSEDFTVLRDYMDDFGLRSPIGRRSAQRLGSRADEVLNSVDPNPVVCECEAVTRAEIQDALDTAGTDLNSVRIQTRASMGNCQGAICCHRMANELAPEYDEKTVRASLDDLYQERWKGERHAMWGTQLSQTALKHMLHAATMNRDEDPAAADADIDFAAFDDGVASGGAVADGGRERAADRADDDALGGADGDN
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone phosphate.  Required for growth on glycerol and for glycerol metabolism.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit A1, G-3-P dehydrogenase A1, G3PDH A1.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NRDR_STRP2
Sequence: MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVEERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RUVC_AERS4
Sequence: MSIILGIDPGSRITGYGVIRIVAGKAEYLGSGCIRTDFGELPSRLKQVYDGVSEIITQFKPDEFAIERVFMARNADSALKLGQARGSAIVAAVNALLPVSEYSATQIKQAVVGTGGAAKEQVQHMVTHLLKLSATPQADAADALGVAICHFHTRQSLIKMAGRATSSVRGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CSRA_SALPK
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQQSSY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
Protein: SYD_LACPL
Sequence: MKRTTYAGLINEDYLGQTVTLQGWVQKRRDLGSLIFIDLRDREGIVQLVFSQEFSADALAVADQLRGEYVIEVQGTVVNRNADAVNDRMKTGKVEVEIHDAKILNKAKTPPFYIQDDINVSDELRLKYRYLDLRRPEMQRGLKIRNGITQAVHSYFDANGFYDIETPFLTKSTPEGARDYLVPSRVYQGHFYALPQSPQLFKQLLMGAGFDRYYQIARCFRDEDLRGDRQPEFTQIDMETSFLTAEEIQSYTEGLIKQVMKDVKGVDIKTPFTRMTWQEAMDRFGSEKPDVRFGMELKDMGVAVSNAGFKVFDNALANGGLVKAIAVPGGADQYSRKQIDAYTEYVKRFGAKGLAWMKVTDDGFSGPVAKFFKNDGDFEAITSAAAAKPGDLLLFAADSFKVVSDTLGYLRTAIAKELDLIDQDQYAYLWVVDWPLFEYDEGIERWVPAHHPFTMPNEEDVHYLNDGEDPHKAHAQSYDIILNGYELGGGSIRIHTRELQEKMFKALDFTKERAQEQFGFLLDALDMGFPPHGGLAIGLDRFAMLLSGNDNIREVIAFPKNSKASEPMTNAPSRVSDQQLADLDLNITNPVTDDEPTE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNRDL_CHICK
Sequence: MEDATEMSGGAEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVEKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGKSNASGGRGGGRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYSDQSYSGYGGYDYSGYNYPNYGYGPGYTDYSGQQSTYGKASRGGGNHQNNYQPY
What is the function of this protein?
Acts as a transcriptional regulator.  Binds DNA and RNA (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein D-like, hnRNP D-like, hnRNP DL.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.
Protein: GAB1_BOVIN
Sequence: MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKAPGSSLQAPADIPLAISTAPPSSQVGASAAAAPPPYQLISLPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGVNGFFQQHMMYDSPPSRAASLSVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVEPQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVDTCSITRTASDTDSSYCIPTAGLPPSRSNTISTVDLNKLRKDASSQDCYDTPRTFPSDRSSSLEGFHNHFKIKNILTAGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPLSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDSNLFGSNSLDGGNSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKNVK
What is the function of this protein?
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases.  Plays a role in FGFR1 signaling.  Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).  Involved in the MET/HGF-signaling pathway.
What are the official names of this protein?
GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the GAB family.
Protein: PQQC_ACIB3
Sequence: MTQTPEALTTEQFKQAIIDKGQYYHIYHPFHVMMYEGKATQQQIQAWVANRYYYQINIPLKDAAIMANCPDQRVRQEWIQRMIDQDGEYPDGGGREAWLRLAEAVGLSREQVISEELVLPGVRFAVDAYVNFARRASWREAASSSLTELFAPQIHQSRLESWPQHYPWIDDKGYEYFRSRLSQARRDVEHGLTITLDSFTTHEQQQRMLEILQFKLDILWSILDALTLAYVHNEAPYHSVTQERVWHKGLFK
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: CDC62_METTH
Sequence: MKGDKRRDIRDILLHDETLFRNMNAFDPDYVPENYRYRESQMEALAVCIRPALRNGRPVNAVILGSCATGKTTAIKKIFEMVESTSEGVVCCYINCQLHTTRFGIFSQIYSKIFGHQPPETGVPFSRIYQTIMQHLASEKRALVVALDDINHLFYSKNANKVLYDILRAHEVFEGVRTGVFAVLSDIEFRYALDKNVDSIFIPQEIVFPPYTREEVFNILRDRVRVGFYPGVISDELLERITDHTMDTGDLRYGIDLLRVCGNLAEADASPVIGEEHLERALKSTGPVNLIHTVRTLNENEREFLRILADAGEDMTAGALYELFRESTGSSYSSFNRIIEKLEFLRLIDTRLTGKGVRGNSRILIPRFSREDLRRCPGF
What is the function of this protein?
Involved in regulation of DNA replication.  Dissociates the MCM complex and inhibits the MCM helicase activity, suggesting that it may function as a helicase loader.  Binds to both specific and random double-stranded or single-stranded DNA.
What are the official names of this protein?
ORC1-type DNA replication protein 2.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: LEPA_STAAW
Sequence: MDNEQRLKRRENIRNFSIIAHIDHGKSTLADRILENTKSVETRDMQDQLLDSMDLERERGITIKLNAVRLKYEAKDGNTYTFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNELELLPVINKIDLPAAEPERVKQEIEDMIGLDQDDVVLASAKSNIGIEEILEKIVEVVPAPDGDPEAPLKALIFDSEYDPYRGVISSIRIVDGVVKAGDKIRMMATGKEFEVTEVGINTPKQLPVDELTVGDVGYIIASIKNVDDSRVGDTITLASRPASEPLQGYKKMNPMVYCGLFPIDNKNYNDLREALEKLQLNDASLEFEPESSQALGFGYRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCILRDGSEVTVDNPAQMPDRDKIDKIFEPYVRATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYELPLAEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHRDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLAKCYGGDISRKRKLLEKQKAGKAKMKAVGNIEIPQDAFLAVLKMDDE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTAP_LEPIN
Sequence: MSYNVRAAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGNGDDLSLKNSTRYSIITAPEKRNSETVKKLRVLFPEYF
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: AMPP2_ASPNC
Sequence: MRVSIPPELVSSLGACDLRVTVRGEGIDKYPGGPGAAKQHARKVAMKLGVSSGLIYLVGKPTINWGDSDQPQPFRQRRYFYYLSGADEPDCYLTYDINNDLLVLYVPDFDLHRAIWMGPTLTTDEAERRFDVDKVRYYASLQSDIQSWVGKYNDAAPVYILHSSQQPQFSVQQLHIDDQRLLPAMDAARVVKDDYELRMIRHANKISGLAHRKVLEQIHKMSNEAQIEGLFLDTCVSHGAKNQAYEIIAGSGPNAATLHYVKNNEPLKGRQLVCLDAGAEWECYASDVTRTFPLAADWPSSHARDVYQIVEEMQEQCIKRIKPGVRFRDLQVLAHDIAIRGLQKLGVLKPGTVEEIRVSGASAIFFPHGLGHHVGLEVHDVSEKPITGMGLPNRPCRPDFIPAMSQSVPLLEEGMVVTIEPGVYFSKLALANSRKLPQARYINFDEAEKYIPIGGVRIEDDILVTRTGYENLTTAPKGDEMLEIIRRGIDN
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase An01g13040, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: DNB2_ADES1
Sequence: MSLSKTKNPALLAGPGDEAKEKVQAALELLHKFGSAFKVDTAGFSFHPESPECDKIFGAYLKNVKHVPTYSSAKTLTSVGGRILYAATCQYVKLTPVTNLTGCTLWEHGWGQNLKCYHGEGMCRKKNEIEMAATSESGVAALKEGRGAVEINRWGRQVVKITQENYVICMEDLQSRFNQPSANSCGLSFSDSDKARSAMENATELTRSIFSQAKMDHLLFMPICCYCNYGGKMILGRQLCKLTPFSISGTEGLREEDVSPVQAVSVRHPAVFVFQCCNATGGSKGKTSCDFKISHADLLQVLNLVRKMWLEVMGYPMPIHFPRFKWSPSLRVKNALLPEGSVNEDENPFGLDNSEDEEEVVPPSPPSPARKRTRTTVAEVHHKKKKKIVLESSEEDE
What is the function of this protein?
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers.  Also enhances the rate of initiation.  Released from template upon second strand synthesis.  Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication.  Covers the whole ssDNA genome during synthesis.  The complementary strand synthesis induces its relese from DNA template.  May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
What are the official names of this protein?
DNA-binding protein, DBP, Early 2A protein, Early E2A DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E2A DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Accumulates in infected cells.
Protein: DDL_LEPIN
Sequence: MAKIAVFFGGSSTEHSISILTGCFICKTLHTMGHSVKPILLTKDGGWVVPSEYRMSIPFEVSNSPDLFQEEFQKRYGVSRTNQIFSLDADIVFLGLHGGQGEDGTIQGFLEILGIPYTGSGVLASAIAMDKTRANQIFLQSGQKVAPFFEIDKLEYLNSTDAVITKLETLGFPQFLKPVEGGSSVSVYKITNREQLKEKLALIFESDSKVMSQSFLTGIEVSCGVLERYRDGKFKKIALPATEIVPGGEFFDFESKYKQGGSHEITPARISEQEMKRVQELAIAAHRSLGCSGYSRTDFIIVNGEPHILETNTLPGMTETSLIPQQAKAAGISMEEVFSDLIEIGLKRSLY
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_CHLTR
Sequence: MKKSIGLVGDTGRMGVLLTQALLCRPHCFLGKGFSRRSQTSLEEVVTENDILVDFSSPEVTSLLLDFLLKTPRPVIIGTTGFTNDSGVKTKLSALSEYVPVVVCANTSLGAYVQKRLAAFAAKLFSTSYDVRILETHHRAKADAISGTAISLAEAIRSAKAESYEEEPEPFIEMHGSRLGNVCGEHEVSFVGEDERFVIRHEVFSRRVFSGGVLLILEKIMGEGLPKGYYTSDVLYESLFQEKVFG
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYS5_ASHGO
Sequence: MAQGSPATVAACAFCGARRTRSGMVLSTSAADGYLDDEAQFETALRLLPAADQAAVRRRRAGRAVVLASRLLRTLGCAVHTGCAPALLAFDYSRAGKPYLRSRPAPAFSVSRSDCIAVIYVREGGAVGADLASVAECLSWAPDEILQLHDVFSAAELGRLRAAAPGRARAELFAYYWSLKEAYGKFRGTGLAGDLRLADMGELDPLRRGELRTLRRTLQGKHVCLSSRWHDAGHVLSLCEAREPSPTEEICLHKVPMEEVVRLCRPSLGMEKCHVR
What is the function of this protein?
Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase.  Necessary for alpha-aminoadipate reductase activity (By similarity).
What are the official names of this protein?
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, AASD-PPT.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
Protein: DOSC_ECO57
Sequence: MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
What is the function of this protein?
Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability.  Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules.  Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity).
What are the official names of this protein?
Diguanylate cyclase DosC, DGC, Direct oxygen-sensing cyclase.
Protein: RLME_SHEON
Sequence: MSGKKRTASSNRWMLEHFDDHYVKLAQKRGLRSRAAFKLEELQQKDQLIRPGMTVVDLGAAPGGWSQVAVKLVGDKGKVIACDILPMDPIVGVDFLQGDFREEKVLEALLTRVGADKVDVVLSDMAPNMSGSDGVDQPRAMYLVELALDMCHQVLAPNGSFAVKVFQGEGFDEYMKAVKEAFKVVKTRKPDSSRARSREVYLVATGYKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S5A1_BOVIN
Sequence: MELAERFLLDALAYLECALGVVCYVLLKLVGSPYGRYASSGSAFGLPARAAWTVQELPSLALPLLACAGAGAPAERLNRWPNCILLAMFLVHYAQRSLVFPFLIRGGKPMPLYAFLLAFIFCTYNGYLQSRYLSQYAVYADDWLSDPRFLTGSALWLIGMLINIHSDHVLRNLRKPGETGYKIPRGGLFEYISAANYFGEVVEWCGYALASWSIQGWAFAVFTFCVLFTRAQQHHKWYHEKFEDYPKFRKIMIPFLV
What is the function of this protein?
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids.  It plays a central role in sexual differentiation and androgen physiology.
What are the official names of this protein?
3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, Steroid 5-alpha-reductase 1, S5AR 1.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ICAB_STAEP
Sequence: MKPFKLIFISALMILIMTNATPISHLNAQANEENKKLKYEKNSALALNYHRVRKKDPLNDFISLLSGSKEIKNYSVTDQEFKSQIQWLKAHDAKFLTLKEFIKYKEKGKFPKRSVWINFDDMDQTIYDNAFPVLKKYHIPATGFLITNHIGSTNFHNLNLLSKKQLDEMYETGLWDFESHTHDLHALKKGNKSKFLDSSQSVASKDIKKSEHYLNKNYPKNERALAYPYGLINDDKIKAMKKNGIQYGFTLQEKAVTPDADNYRIPRILVSNDAFETLIKEWDGFDEEK
What is the function of this protein?
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  In fact, the IcaB deacetylase converts 15 to 20% of the GlcNAc residues of PNAG to glucosamine.  N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions.  Deacetylation of the polymer is also essential for key virulence mechanisms of S. epidermidis, namely biofilm formation, colonization, and resistance to neutrophil phagocytosis and human antibacterial peptides.
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase, PNAG N-deacetylase, Poly-beta-1,6-GlcNAc N-deacetylase, Biofilm polysaccharide intercellular adhesin deacetylase, Biofilm PIA deacetylase, Intercellular adhesion protein B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Attached to the cell surface.
Protein: DEF2_XANCP
Sequence: MALLPILEFPDPRLRTKAVPVDAAEVVSPAFQTLLDDMFQTMYEAPGIGLAASQVDVHKRFMVIDVSEEKDAPQVFINPEIVTRQGEQVYQEGCLSVPGIFADVSRADAITVRYLDRQGQPQELSTDGLLAVCIQHEMDHLDGKLFVDYLSPLKREMVRKKLAKLRKHVA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 2, PDF 2, Polypeptide deformylase 2.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: MSHR_ERYPA
Sequence: MPVQGSQRRLLGSLNSTPTATPHLGLAANQTGARCLEVSIPDGLFLSLGLVSLVENVLVVTAIAKNRNLHSPMYCFICCLALSDLLVSGSNMLETAVILLLEAGALAARAAVVQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVLFSMLFIAYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPAHQSFGLKGAATLTILLGIFFLCWGPFFLHLTLIVLCPQHPTCSCIFKNFNLFLTLIICNAIIDPLIYAFRSQELRRTLKEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PVAA_STRR6
Sequence: MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREMLSEKDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLYLAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLALAKQYSRETVAPLLGNRTGKTYSYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG
What are the official names of this protein?
Pneumococcal vaccine antigen A.
What are the subcellular locations of this protein?
Cell surface.