Protein: ALT1_ALTAL
Sequence: MAIVTAFEDEPINGNGMLNAPSISPDPVLPLAIVGMGMRLPGAIHTPEHLWQTLVNKRSTRCEIPDTRFSTNGFHSPSAKPGSIAMRHGHFLADSDSLHHLDPSFFSMGMNEAVDIDPQQRLLLEVVYECMESSGQVNWQGSKIGCWVGVWGEDWLDLHAKDTFDSGMFRIAGGHDFAISNRISYEYNLKGPSYTIKAGCSSSLIALHEAVRALRAGDCDGAIVAGTNLIFSPTMSIGMTEQGVLSPDASCKSFDANANGYARGEAINAIYLKRLDVALQNGDSVRAVVRGTSSNSDGKTPGMSMPSSESHISLIRQAYREAGLDPAQTPFVEAHGTGTPVGDPLEAIAIARVFGGRDRTLYLGSVKPNLGHSEGASGISSILKAIQAMEHRTIPPNLNFNVPNPKIPFAESNMVVPCASVPWPEGQPVRVSVNSFGIGGSNAHCILESVEEYLGAHGAPWMPIGTRLSNTYTSCFPRLNFNKTDGGISTTSLSARSVNGMTNLIVHSTDEEMMQSPAVQARESYSNHHTLTETTNPSNNTATNGVVGYQPRKLLYVVSAGNATSLTAKIMDLHRYHQDHQAQAVDVAYTLCNRRDHLTHRTYAIASAQPSEGCLSDPALEFSPPAKINTTTPSHAVMVFTGQGAQWAGMASELVSDYPVFRATVSRLSRVLSQLEHAPAWNLLEELRKPEATSRIGEAEFSQPLVCAVQVGLVDLLRHWGLSAAAVIGHSSGEIGAAYAADAITADEAITIAYYRGYVNKSHTRQGGMAAIGLGVSQVAPFLSEGVTIACDNSPQSATISGDKDVLRDVCSMIRRKQPDCLVRELKVPAAYHSHHMLDLGGTLESLLKGKVHSQAPAIPFFSSVKVKEIREPGSLDAAYWRENLESPVQFTGALKILLAAQPSLSRTVFVEIGPHSALAGPLRQIFKAHGTGQEGYTPAMIRGKDCVDSVLSLVGDLFLQGITLDLSRISPPANVITDLPLYPWNHEKEFWSESRVGRDWRFRKYPNHELLGSQTLESSKLQPQWRNMLKLEHVPWLRDHQVMNDTIFPCAGYLAMAVEAVRQATEAADVEGFSLRNVVVRAALVVTESKPVELLTALQPVRLTNTLDSVWWEFSIMSHNGSVWQKHCNGQVRPGRDAHHIKAAFSEQAVVSRDKQYPRPVDSLYSELYRLGLRYGPAFCGLNKVHCQPGGKQASAILMETIVSESSYAIHPTTIDHCLQLLFPASCEGIFYRAEKLCVPTGIDNLYLADGKTRESEGARIEASSVARSGGAIFGAAKAFSKIDDALLLSLEGGKFSPIEVDDGIVEDLDPLASAHLVWKPHLDFADMHDLIRPNQDLINDRHNIDLVERLTLVAMMFIQERMGSVSSPANLDHIARFRNWIDAQVAGLKNGTYSGLEKDVEELLSLKPNDRLPLLKELEQIIIQSAPASTAVLICRIIDRCDDILQGRIDGIEVLQADNGLTNFYNYIESRTESVDFLTAAGHTQPTLRILEIGAGTGGASQVVLDSLTNQAEHSRLYSTYAYTDVSAGFFVAARERFKKYPALDFRVLDISKDPLEQGFHASSFDLIIANNVLHATPFLSQTLANVRKLLAPEGYLFLQELSPKMRMVNLIMGILPGWWLGAAEGRSEEPYLSPEQWDSLLRQTGFSSVDVVYDAPSPYQVNANIIARAASEPQARDEKSNGALGAPKAVLLHAPGDEVSERAAQIRSSLEESGLDTSLISIEQFQANATDTQGIIVSLLDLTTPFFASMSASKLTAIQSLVANLGSAHMMWILPRAQKDVSCSDDPAYGMSLGLIRTLRSERSVAITTVEVDTFDNAAFSAVARLAIKLAHQQQGDRTSISSGSDLDPDREFVLTKGVLETGRFHPVSLTHEMAAHAPASEATTLRIGRAGLLQTLKWVDLAIKEPEHNEVVVEPRCVGLNFRDVLVCMGIVEANDVSIGLEGSGVVRKVGNGVTGLQAGDRVFYMADNCFSSQITISALRCVKIPSSLSFEQAATMPCVYATVIHSLLDMGGLQSGQSVLIHSACGGIGIAALNLCRAMPGVEVYVTVGSEEKVQYLMQEFGLAREQIFHSRDTSFVEDVRAATGGRGVDVVLNSLSGELLHASWECVAPYGKMLEIGKRDFIGKAQLAMDLFEANRSFIGIDLARFDAARCGRLLQRTIDMYVAGAIQPVAPIKVFGATEAEASFRYMQKGTHLGKIVVSIGKAAAAAATTRQAVPTQLNPVATYVLVGGLGGLGRAVATWMVERGARHLLFLSRSAGQQAAHQAFFTELQCQGCSAQAVQGDVTLLGDVERALAAAPAGKPVRGILQMAMVLRDKAFADMDLADWHDTVTAKVLGTWNLHRAAPADMDFFLATGSISGLFGLPGQANYAAANSYLTALVQHRRAHGMPASVVHIGMIEDVGYLAENPARADALRAAGGFFLRTRQLLQAIDWALAPPSHKPHHLDHELAIGLRTTKPLLDPGNRVVWRSDPRMGLYHNLTATVATTADDGSDDSDALRFFITSITAEPALLDDPASLDLVTRTIGTRIYTFMLHPLDDIDSTASLTALGVDSLVTIELRNWIKRNFAGLDFSTLEILDARTIAGLAKLILDALKARFGSSTADQQRLQSDYLNMKAP
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype (PubMed:18435561, PubMed:19749175, PubMed:19449880).  The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units (PubMed:18435561, PubMed:19449880).  ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin (PubMed:19449880).  The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable).  This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable).  The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable).  The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref. 5).
What are the official names of this protein?
Highly reducing polyketide synthase ALT1, HR-PKS FUM1, AAL-toxin biosynthesis cluster protein 1.