PharMolix/UniProtQA huggingface dataset:
Protein: MRAY_GEOSL
Sequence: MLYHLLYPLAADFRIFNVFKYLTFRTIYAVITALVVSFILGPWVIRKLEALQARQVIRTDGPESHLKKSGTPTMGGILILASIVIPTLLWADLTNRYVWTTLFVILGYGLIGFTDDYKKVVEKDTKGLSPRQKMFWQMLIAGGAVCFLVLVAGMSTELSVPFFKRLHPDLSYLYIPFGMLVVVGASNAVNLTDGLDGLAIGPVAINAATFLLFAYIAGNAKLSSYLQTPYVPGAGELAVLCGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGILAVITKQEMLLVIVGGIFVVEALSVIFQVGSYKYRGKRIFRMAPIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y605_RHOJR
Sequence: MRTDGDSWDIVSSVGLTALGVATFRALETVRPDALIQDDYARWFVEAAGEPHFTGLLADPSLLGDMRFSGFMGSRTRFFDEFFSSATGAGVSQAVILAAGLDARAYRLDWPTGTTVFEVDQPQVLEFKAEVLADHGATAKADRRPVAVDLRDDWPAALEAAGFDPGKPTAWSVEGLLAYLPGAAHDALFERIDELSSPGSHVAVDNFAEGTDMQRFDAIRAKYFAENPFGDIDIAELFYGDERADPVQWLTGHGWSVRRSTSLELAAAYGRPVPDLPEELVDLSERSTYLTAVK
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase RHA1_ro00605.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: YGGU_ECO81
Sequence: MSAVTVNDDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANSHLVKFLGKQFRVAKSQVVIEKGELGRHKQIKIINPQQIPPEIAALIN
What are the official names of this protein?
UPF0235 protein YggU.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: EXP26_ORYSJ
Sequence: MDTTTTMAPLPLLTTTSLLLFFFLASSFAADVVVAGGGGGGGGYDGGGDGEGGGGGDGEGGGGGGGAKMPHVNHGRYKCGPWVDGHATFYGGRDASGTTEGGACGYKDADGYGAMTAAVSPALFDNGAGCGACYELKGDSGKTVVVTATNQAPPPVNGMKGEHFDLTMPAFLSIAEEKLGVVPVSYRKVACVRQGGIKYTITGNPSYNMVMVKNVGGAGDVVKLTVKGTKRVKWTPLQRSWGQLWKTEANLTGESLTFRVMTGDHRKATSWRVAPRDWTYDNTYQAKKNF
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A26, Alpha-expansin-26, OsEXP26, OsEXPA26, OsaEXPa1.29.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: UVRA_XANAC
Sequence: MAMDFIRIRGARTHNLKNIDLDLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLSVMEKPDLDHIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLYARVGQPRCPDHGFPLEAQTVSQMVDHMLAQDQEQRYMLLAPVIRDRKGEHAQVFEQLRAQGFVRVRVDGELYEIDAVPPLALRQKHTIEAVIDRFRPREDIKQRLAESFETALKLGEGMVAVQSLDDPAAAPHLFSSKYSCPVCDYSLPELEPRLFSFNAPVGACPSCDGLGVAEFFDPDRVVVHPELSLSAGAVRGWDRRNAYYFQLIASLAKHYKFDVDAVWNTLPAKVRQAVLFGSGDEVISFTYFTDAGGRTTRKHRFEGILPNLERRYRETESPAVREELTKYVSQQPCPACNGTRLNRAARNVFVADRPLPELVVLPVNEALSFFRGLSLPGWRGEIAAKIVKEIGERLGFLVDVGLDYLTLERKADTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLTRLRDLGNTVIVVEHDEDAIRLADHVLDIGPGAGVHGGEICAQGTLDDILKSPRSLTGQYLSGKRRIEIPKQRHKPNPKMMLHLRGATGNNLKNVDLDIPAGLLTCITGVSGSGKSTLINDTLFTLAANEINGASHTVAPHREVENLDLFDKVVDIDQSPIGRTPRSNPATYTGMFTPLRELFAQVPEARARGYSPGRFSFNVRGGRCEACQGDGMIKVEMHFLPDVYVPCDVCHGKRYNRETLEIRYKGFNISDVLQMTVEDALRLFEPVPSIARKLETLVDVGLSYIKLGQSATTLSGGEAQRVKLSKELSRRDTGRTLYILDEPTTGLHFHDIEALLGVLHKLRDEGNTVVVIEHNLDVIKTADWIVDLGPEGGHRGGTILVSGTPEEVAAHKASYTGQFLAKMLPSVKARETRPAAMANKPDARPPRKVKPEKVAKAAKSATKKTAKKAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMA_ENTFA
Sequence: MENLTNISIELNQQFNTKEEAIRFCGEKLVEAGCVEPAYIEAMIERDQLLSVYMGNFIAIPHGTEEAKKLVKKSGICVVQVPEGVNFGTEEDEKIATVLFGIAGVGEEHLQLVQQIALYCSDMDNVVQLADALSKEEITENLAIA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
Mannitol-specific phosphotransferase enzyme IIA component, EIIA, EIII, PTS system mannitol-specific EIIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_SALNS
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRARGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNDDMIAQLESRIRAKASQLDEARRIDVLQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RK23_GUITH
Sequence: MHALIDLVKYPLITDKATRLLELNQYTFLTSRVATKTDIKNAIEFLFNVKVISINTCLLPLKRKRLGKFVGSKPRYKKAVVTLEKNNTINLFSEN
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRBP2_BOVIN
Sequence: MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDVPVFTAAAAATPVPSAVPTRSSPMEVQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPEDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCSVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSAATREAARGEAARRALQYLKIMAGSK
What is the function of this protein?
Required for formation of the RNA induced silencing complex (RISC).  Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2.  Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2.  AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2.  May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
What are the official names of this protein?
RISC-loading complex subunit TARBP2.
What is the protein family that this protein belongs to?
Belongs to the TARBP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein: RHD31_ARATH
Sequence: MDADKSEGCCSVQLIDGDGIYNVSRIDHFIKDVKLADCGLSYAVVSIMGPQSSGKSTLLNHLFGTNFMEMDAFKGRSQTTKGIWLARCAGIEPCTLVMDLEGTDGRERGEDDTAFEKQSALFALAISDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTMLFVIRDKTRTPLENLEPVLREDIQKIWDSVPKPEAHKETPLSDFFNVEVVALSSYEEKEEQFKEQIASLRQRFMHSIAPGGLAGDRRGVIPASGFAFSADQIWRVIKENKDLDLPAHKVMVATVRCEEIANEKFAHFITNEDWRKLDEEVQAGPVSNFGKRLTTILGSCLSEYDGEATFFDEGVRSSKRQQLEEKLLQLVNPAFQDVLGHIRWGILEKFKASFDKALGIGEGFSSASQDWFKACMTQFDEECAGAIIEQANWDTSKVRDKLVRDIEAHISSVRTSKLSELTSLYESKVHEALSEPVEALLDGANDETWSTVKKLHRRETESAVSGLSSALAGFDMEEETRDRMVKSLQDYARGVIETKAKEEAVRVLMRMKERFGTIFSHDSDSMPRVWTGKEDLRAITKSARSASLKLLSVMAVIRLGDEPDNIEKTLTVALLDPTKNDTSKKSITTSDPLASSTWDEVPSSRTLITPVQCKSIWRQFKTETEYTVTQAISAQEANRRGNNWLPPPWAILALIVLGFNEFMTLLRNPLYLGVMFVAFLLAKALWTQLDIPGEFRNGALPGLISISAKFVPTVMNLIKNLAAQGEDPPAANPENRRSSNNTSSSENPPDHKSSSKED
What is the function of this protein?
Probable GTP-binding protein that may be involved in cell development.
What are the official names of this protein?
Protein ROOT HAIR DEFECTIVE 3 homolog 1, Protein SEY1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RLMC_ECO45
Sequence: MQCALYDAGRCRSCQWITQPIPEQLSAKTVDLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSDTKLAQLRKALPWLQEQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIAPEAIACAKQSAAELGLTRLQFQALDSTQFATAQGEVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLLVKQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: PTD_ARATH
Sequence: MATAGSSYSVSTDHQVSSPLVNLGNVAGVCIMSNAWKVEQEPSLINFISAFLSANSFRLNFVSIPPDLIFNCGGVSIAFVFVTKWDFSNVASIFSRVKRLKGQFAQLYVVATLSTKEQSDSFMRSYFQYEMEFGKPAFVQVTDAEMGFEKIVKIAHSRGVCKQQKVASKLKVERKRTVQDTNIFIRFVTSIPNINKHDANTLYQAIGSIEAIAKASKEDILANTDLSSKKADTLTRFFQDPEFYLSPKFN
What is the function of this protein?
Required for chromosome segregation during meiosis (PubMed:16394097).  During diakinesis and prometaphase I, essential for the formation of class I meiotic crossovers and homologous recombination (PubMed:16394097, PubMed:21771883, PubMed:24656236).
What are the official names of this protein?
Protein PARTING DANCERS, AtPTD.
What is the protein family that this protein belongs to?
Belongs to the ERCC1/RAD10/SWI10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FEN12_PHYPA
Sequence: MGIKGLTKLLADNAPDSMKEQKFESYFGRKIAIDASMSIYSFLVVVGRTGTDMLTNDAGEVTSHLIGMFNRTIRVLEAGLKPVYVFDGKPPEMKGGELAKRLARREEAVESLATAKLEGNEADMEKYSKRTVKVTKQHNEDCRKLLRLMGVPVVEAPSEAEAECASLCKTGKVYAVASEDMDSLTFGSTRFLRHLMEPVSRKLPVMEFDMNKVLEGLSLTMDQFVDLCILCGCDYIDTIRGIGAQTALKLIRQHGSLEKILENLNKDRYQIPDPWPYEEARRLFKEPLVTQAEDVPDFKWTAPDAEGLIKFLVEENGFNHDRVQTAIKKIQLAKNKSSQGRFVNCLCRL
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1-B, FEN-1-B, Flap structure-specific endonuclease 1-B.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RS7_METB6
Sequence: MAEAEVKAQPEGDAAPQSKALLFNKWDVSEVKVTDPSLVRYVNLTPQIIPHSCGKFSRQEFNKANMMIVERLINRLMQTENNTGKKQLAIGIVRDAFELINKKTKRNPIEVLVEAIGNTGPREETVRLKYGGINVPKSVDTAPLRRVDSAIGFIAEAVWKSSRKSKKPASAILADELIAASKGDAKCYSVGKKEEKERIAKSAR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS13_EXIS2
Sequence: MARIAGVDIPREKRIVISLTYIYGVGKTTAQKVLKEAGISEDTRTRELTEEQLNQLRDGLDKVKVEGDLRREISLNIKRLIEIGCYRGVRHRRGLPVRGQNTKNNSRTRKGPRRTVANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PUR7_BRUSI
Sequence: MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQLNRIGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEFYYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVNDFLTGLFLGIGIQLVDFKMECGRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMNENDTPRPSGPTLVK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: COXX_BACAH
Sequence: MNHATSELHDESAVTSIPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVLDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GSA_ROSS1
Sequence: MKTTRSESLFAEAQSLFPGGVNSPVRAFRAVGGTPRFIARGEGALIFDVDGNRYIDYVLSWGPLIAGHTHPDVVAAIAEQAARGTSFGAPTELESELARLIIQAMPAVEMVRFVSSGTEAAMSALRLARAATRRDKVIKFAGCYHGHFDGFLVQAGSGVATLGLPDSPGVTAATAAGTLTAPYNDLDAVEALLKANPGEVAAIAVEPVAGNMGLVLPQPGFLAGLRRLADEHGALLIFDEVMTGFRVAYGGAQGRYGITPDLTCLGKVIGGGLPAAAYGGRRELMELIAPAGPVYQAGTLSGNPLAMAAGIATLRIIGAPGVFERLEQATAALCAGFERAAADADIPLRAAYAGSMWGFFFTGDPVVDYASAKKADTRRYARFFHAMLERGVYLAPAQFEAAFVSLAHSDALIQETIAAAADALRSL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTM_MYCTU
Sequence: MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQPELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELARHEAAKRGLANASFEVADASSFTGYDGRFDTIVDSTLFHSMPVESREGYLQSIVRAAAPGASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFPAGFAGMPALLDIREEPNGLQSIGGWLLSAHLG
What is the function of this protein?
Involved in cellular response to chemical stress and may contribute to resistance toward antimicrobial natural compounds as well as drugs (Probable).  Catalyzes the methylation and detoxification of the P. aeruginosa toxin 2-heptyl-1-hydroxy-4(1H)-quinolinone (HQNO) to 2-heptyl-1-methoxy-4(1H)-quinolinone (HMOQ) (PubMed:33064871).  Can also methylate 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone, and shows much lower activity with 1-hydroxyquinolin-4(1H)-one, quercetin, 4-hydroxyquinolin-2(1H)-one (DHQ) and 4-hydroxyisoquinolin-1(2H)-one (PubMed:33064871).  In addition, N-methylates and abolishes the mycobactericidal activity of 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (compound 14), an inhibitor of DprE1 (PubMed:27432954).  Also methylates and reduces the inhibitory effect of TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl)-2-thienyl]acetic acid), an inhibitor of GlmU acetyltransferase (PubMed:31380295).
What are the official names of this protein?
2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase, HQNO methyltransferase, HQNO-MTase, Heterocyclic toxin methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_MYCTU
Sequence: MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NSRH_ASPN1
Sequence: MDDLAQLQSCSNELATAITSLASYAGSGNTQQAINNQSPFEPEEVQRAKGNILAVATKLRTLICGPTDFLQHLASQVSEILACLRWLGEFQILACIPLMGSAPIKDIADLTNVPESRLRRIIRLTATAGFLREPERDHVAHTPLSASFFSNPSLLDAAMFLSESAAPIALQMPQTAQVKEKSSSPPSNGTPCDLALPRGTEFHTACKRRPKLNRQWLAYLHHAAGLHTADDIAAVLTQLDWPKLTNGRDGSIIEYAISRVDHCHAQVGVSSWSTSIARRLAHFYPALHFTVQISDPAVAITQEEFHPRITATSRILGTRQTAAGAAVYILHLPFASSSPSAVMTELAVHLDVLRSRSGILLILTPRLLPQPGSLPDPEVEATARSRDLALGQMADEGEMEMLELLETIDTVRDSLGKLVVTSKLRSRNNLVVAVTVEYQRDLPS
What is the function of this protein?
Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin, which exhibits antibacterial activity.
What are the official names of this protein?
Transcriptional coactivator nsrH, Neosartorin biosynthesis cluster protein H.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTS_STRZP
Sequence: MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREKGMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAEGKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNGGRIGVISVVEGGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNESRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEAEVAATMAAALNN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_STAHJ
Sequence: MTNQNLNKDKAIVVFSGGQDSTTCLFYAKKHFKDVELVTFNYGQRHDAEIEVATRIAKEQNLKHHILDMSLLSQLTPNALTQHDMDIETGEDGIPNTFVPARNLLFLSFAGALAYQRNAKHIITGVCETDFSGYPDCRDSFIKSMNVTLSLSMDKDFVIHTPLMWLDKAQTWELSDELGVLDYIRHNTLTCYNGVIGDGCGECPACQLRQRGLQHYLEAKGAN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MURI_STAAE
Sequence: MNKPIGVIDSGVGGLTVAKEIMRQLPNETIYYLGDIGRCPYGPRPGEQVKQYTVEIARKLMEFDIKMLVIACNTATAVALEYLQKTLSIPVIGVIEPGARTAIMTTRNQNVLVLGTEGTIKSEAYRTHIKRINPHVEVHGVACPGFVPLVEQMRYSDPTITSIVIHQTLKRWRNSESDTVILGCTHYPLLYKPIYDYFGGKKTVISSGLETAREVSALLTFSNEHASYTEHPDHRFFATGDPTHITNIIKEWLNLSVNVERISVND
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CSSA2_ECOLX
Sequence: MKKTIGLILILASFGSHARTEIATKNFPVSTTISKSFFAPEPRIQPSFGENVGKEGALLFSVNLTVPENVSQVTVYPVYDEDYGLGRLVNTADASQSIIYQIVDEKGKKMLKDHGAEVTPNQQITFKALNYTSGEKKISPGIYNDQVMVGYYVN
What is the function of this protein?
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0. 5-1. 5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.
What are the official names of this protein?
CS6 fimbrial subunit A, CS6 pilin.
What are the subcellular locations of this protein?
Fimbrium.
Protein: ALL1_CYDPO
Sequence: SPHYNFGL
What are the official names of this protein?
Cydiastatin-1.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HDA_PROMH
Sequence: MLESRRLLNYSGEVLLNTPSQLSLPLSLPDDETFDSFYAGENASLVAAIQTAIHQSHGSYIYFWSRDGGGKSHLLHAACAELSLAGDAVGYVPLDKRAYFVPDVLEGMEHLSLVCIDNVQCIAGDEEWELALFNLYNRVLELGRTCLLITGDRPPRQIDLQLPDLASRLDWGQIYRLQPLSDEEKIQALQLRAKLRGFELPEDVGRFVLKRLDRKMRTLFEMLDELDHASIVAQRKLTIPFVKDILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: Y2221_ARCFU
Sequence: MLASDSKLIRIRNFEACLGVVLEIKEPVGFKRRYLNFIEEIKSAYQISSPRNVFKSYELKRKLGLQDFEDVAQNFVNIVIADSCRIHIVFASFNTKKVEKVIYYRKDRRKRQQEKKTIEFLRHLSSYFPYVAAWSAIFNDEAISFDNIEIHLDSFDGEVTYAWEILKNNISAKIKTFPKGDQCNPFISASDIVLSLVEINLLKGDFRLDVQELKKLLEKYNIKGSITHCGTNKIKYITPISSQKIPEALDYAEPVIYVVPGQIKKEWIENSPKFEYVLKYAQFVEGGVKFLNIDRDYEFIRDTDVLAYFDDAGKVLAKNISSLYDVECKSISEIINETKY
What are the official names of this protein?
Uncharacterized protein AF_2221.