PharMolix/UniProtQA huggingface dataset:
Protein: RS12_SHIF8
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GLMM_SULNB
Sequence: MTLFGTDGVRGKAGKKVSAVNTMRLAMATGIYFKQFAKTNKILVGKDTRRSGYMIENALVSGLTAVGFDVIQIGPMPTPAIAFLTENMRCDAGIMISASHNPYYDNGIKFFDSEGNKLNRSEEEKIEEIFADDDALEDAQVTGKYIGKSKRIDDVIGRYIVHIKNSFPKSLSLAGKRVVIDCANGAGYIVGPTVLQELGAEVVVVGDEPDGFNINEGCGAMHPENLAKVVLDKRADIGLALDGDADRLVVVDEKGETVDGDKLMAVLAVHLKNTGELRGDGMVATVMSNQGLEEYLLEHGITVYRSAVGDKNVVEMMQEKGVNFGGEQSGHIIFSDYAKTGDGISSALQALAYLVSTGTKTSEAFNPYESYPQMLVNLPIEEKKPLESIEGLEQLMEQVEAEGMRHLFRYSGTENKIRLLLEGKNEKALETMMDECMDFFKRTLV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ARNF_ECOLU
Sequence: MGLMWGLFSVIIASAAQLSLGFAASHLPPMTHLWDFIAALLAFGLDARILLLGLLGYLLSVFCWYKTLHKLALSKAYALLSMSYVLVWIASMILPGWEGTFSLKALLGVACIMSGLMLIFLPTTKQRY
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AACUF_ASPA1
Sequence: MPSYLITGGSRGLGYAWLKHLSSNPQNTVIGLVRDKSSPHSHPLADRLTNVHHVCADITDPKALQTAAEQVRAITGGGLDVLINNAAILTPTSAFTPITDLSPGVLERDILQSCRTNVVGVAHTVNAFLPLIRKGRAKKVITISSLLADPDLVRNFALDNAMPYAISKAAANLLMAKYHASLGATEGILFMAISPGAVSKPDTAPSEGEAEGRRRMAAKLQAYAPHFSRPMTMEESVRRQLEVIENATVELHGGAFVSHLGNKQWL
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer secalonic acid D (PubMed:30996871, PubMed:33891392).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase AacuL (Probable).  The atrochrysone carboxyl ACP thioesterase AacuM then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase AacuI, and oxidized by the anthrone oxygenase AacuG to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by a yet unidentified oxidoreductase (Probable).  A-ring reduction by the short chain dehydrogenase AacuN, dehydration by the scytalone dehydratase-like protein AacuK and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:33891392).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) AacuH then yields monodictyphenone (PubMed:33891392).  Monodictyphenone is transformed into compounds with the tetrahydroxanthone skeleton via methylesterification by the methyltransferase AacuQ, followed by the action of the flavin-dependent monooxygenase AacuC, the isomerase AacuP, and the short chain dehydrogenase/reductase AacuF or AacuD (PubMed:33891392).  AacuF and AacuD should accept the same compound as a substrate but perform the ketoreduction with a different stereoselectivity, thus yielding blennolides B and A, respectively (PubMed:33891392).  In the final step of the biosynthesis, the cytochrome P450 monooxygenase AacuE accepts blennolide B and/or blennolide A to conduct the dimerization reaction to furnish the tetrahydroxanthone dimers, secalonic acids D, B, and F (PubMed:33891392).
What are the official names of this protein?
Short-chain dehydrogenase/reductase AacuF, SDR AacuF, Secalonic acid biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ISPT_LACJO
Sequence: MSESKKPLNHLAIIMDGNGRWAKKRHLPRFVGHRHGMDNIRNIALAANKLGIKVLTLYAFSTENWARPTDEVNYLMRLPIDFFDKFMPELMENNVRVNIMGFVDELPEKTYLVTQKAMAETANNTGMVLNFAFNYGSRREITAGVQEIARKVKVGEIDIDDISEKMVSDHLLTHSLAPYEDPDLLIRTSGEERLSNFLLWQMAYTEFSFSDKLWPDFDKTDLEELVKDYQGRNRRFGKV
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: THIC_PROMS
Sequence: MRSSWIKPRLGKDNVTQMNFARNGYITEEMDFVAKKENLPSSLIMEEVARGRLIIPANINHLNLEPMSIGIASRCKVNANIGASPNASDINEEVEKLKLAVKYGADTVMDLSTGGVNLDEVRQAIIQESPVPIGTVPVYQALESVHGSIDRLTEDDFLHIIEKHCQQGVDYQTIHAGLLIEHLPKVKGRITGIVSRGGGILAQWMLHHFKQNPLYTRFDDICEIFKKYDCTFSLGDSLRPGCLHDASDDAQLAELKTLGELTRRAWEHNVQVMVEGPGHVPMDQIEFNVRKQMEECSEAPFYVLGPLVTDISPGYDHISSAIGAAMAGWYGTSMLCYVTPKEHLGLPNAEDVREGLIAYKIAAHAADIARHRAGARDRDDELSHARYNFDWNKQFELSLDPERAKQYHDETLPEEIFKKAEFCSMCGPKHCPMNSKISDESLDQLKDKLEECNTSV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: VATD_MANSE
Sequence: MSGKDRLAIFPSRGAQMLMKGRLAGAQKGHGLLKKKADALQVRFRLILSKIIETKTLMGEVMKEAAFSLAEAKFTTGDFNQVVLQNVTKAQIKIRSKKDNVAGVTLPIFESYQDGSDTYELAGLARGGQQLAKLKKNFQSAVKLLVELASLQTSFVTLDEVIKITNRRVNAIEHVIIPRLERTLAYIISELDELEREEFYRLKKIQDKKKIIKDKAEAKKAALRAAGQDLRDSANLLDEGDEDLLF
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit D, V-ATPase subunit D, Vacuolar proton pump subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: ASP4_STRGN
Sequence: MAKKDLFHKDIEGRLDELKHGKPKKEKASLGENLNKIFVIALGLMILIGLIFTLIGALRK
What is the function of this protein?
Part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon.
What are the official names of this protein?
Accessory secretory protein Asp4, Orf5.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TRAF_ECOLI
Sequence: MNKALLPLLLCCFIFPASGKDAGWQWYNEKINPKEKENKPVPAAPRQEPDIMQKLAALQTATKRALYEAILYPGVDNFVKYFRLQNYWAQQAGLFTMSARKAMLAHPELDYNLQYSHYNGTVRNQLAADQAQQRQAIAKLAEHYGIMFFYRGQDPIDGQLAQVINGFRDTYGLSVIPVSVDGVINPLLPDSRTDQGQAQRLGVKYFPAMMLVDPKQGSVRPLSYGFISQDDLAKQFLNVSEDFKPNF
What is the function of this protein?
Involved in F pilus assembly.
What are the official names of this protein?
Protein TraF.
What are the subcellular locations of this protein?
Periplasm.
Protein: CXP5_PARCG
Sequence: GWPAYPGSNGIRSSVCQKKLGCGSKNLASLGVCKAFCLGRKRFWQKCGKNGSSGKGSRICNPVLAHAVEKAGKGLIKVTDMAVAAIVKYAGKK
What is the function of this protein?
Cytolysin that shows hemolytic activity (on bovine erythrocytes, HC(50)=5. 75 mg/ml).  This hemolytic activity is completely inhibited by small unilamelar vesicles composed of PC/PG, PC/PI and PC/PS in 1:1 molar ratios (with at least 100 mg/ml concentration).
What are the official names of this protein?
Parbolysin P5, Parbolysin 5.
What is the protein family that this protein belongs to?
Belongs to the worm cytolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ETFR1_DICDI
Sequence: MENTHSMISFKTLNKLKIQQLFSIKNKSFYSTSSPISSTVNSSGNDNIDIENDKEIKKKNRLIVKDLYKQLMYLGRVGFLGVDYIRDKAKPQFISNANLTDNNKINECIERTKYVIKEIEAMNRFHKYRNLKKSYDLEFQKVNDNFLNLDNDQNKIK
What are the official names of this protein?
Electron transfer flavoprotein regulatory factor 1 homolog, LYR motif-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RAB35_HUMAN
Sequence: MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCDDVCRILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNLAKQQQQQQNDVVKLTKNSKRKKRCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane.  During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.  May indirectly regulate neurite outgrowth.  Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
What are the official names of this protein?
Ras-related protein Rab-35, GTP-binding protein RAY, Ras-related protein Rab-1C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065).
Protein: CLSA_SHIB3
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEIVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWHRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S38A6_RAT
Sequence: MQASRYSIEAEPGWYVSVQQPEEAVAAEEWSPLLSNEPRRQGSSGASFGLSVFNVMNAIMGSGILGLAYVMANTGILGFSFLLLLVALLASYSVHLLLAMCIHTAVTSYEDLGLFAFGLPGKVVVAGTIIIQNIGAMSSYLLIIKTELPAAISEVLPSDHSGAWYLDGQMLLIIICVGIVFPLSLLPKIGFLGYTSSLSFFFMVFFALVVVIKKWAVPCPLTLNCINAVFQISNATDDCKPKLFHFSKESVYAIPTMAFSFLCHTSVLPIYCELRSPSKKRMQNVTNTAIALSFLVYFVSALFGYLTFYDKVESELLQGYSKYLPHDAAVMAVKLCILFAVLLTVPLIHFPARKALMMILFSNYPFSWIRHSLTTLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFVFPGLFYLKLSREDFLSWKKLGALSLLSTGTVVGSFSLVLIILDWVNK
What is the function of this protein?
Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
What are the official names of this protein?
Probable sodium-coupled neutral amino acid transporter 6, N-system amino acid transporter 1, NAT-1, Na(+)-coupled neutral amino acid transporter 6, Solute carrier family 38 member 6.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Colocalizes with synaptotagmins and SNAP25.
Protein: DBP7_ASPCL
Sequence: MADDGLLLNFSLGDSNVIKAEPKLKGGTWRDRLSARKIAQHRSKGPRKPGDENTAPRVPRNPNQIEVSATRPQKRQRTDGGDGGRPQSHAQSNQPRQFISSLFTKNPEPKNVEEVKEEGPVEEAKPTNAPLIDGLDTFTNLGLSPSLAAHLLTKLELKAPTAIQKASISQLLKEDGDAFIQAETGSGKTLAYLLPLVQRIMTLSKPTTDATGQPIVHRDSGLFAIVLAPTRELCKQISVVLESLLRCAHWIVAGTVIGGEKKKSEKARLRKGLNILVATPGRLADHLENTKVLDVSNVRWLVLDEGDRLMELGFEEEIQGIVKKLDARQRPSRIPGIPTKRTTVLCSATMKMNVQKLGEISLKDAVHIKADPEDEDEKARLANKEEDSAYRVPAQLKQSYAVVAAKLRLVTLTAYLKRTFMRKGSVMKTIVFVSCADSVDFHFEVFTRKKQQTDDADASDEEKTEEKPLSPHGTIAPATAFSNPSNPVTLYRLHGSLPQNVRTSTLASFAKNREPSVLICTDVASRGLDLPNVDLVVEYDPAFSAEDHLHRIGRTARVGRDGRALVFLMPGCEENYVEILKRGYRDGGKALTRVDANDILKRGFGGNVEAGKKDWDVKATDWQCEVERWSLENPQYLEMARRAFQSHIRAYATHIAAERSMFNIKELHLGHLAKAFALRDRPSKINVPGLRQGKEETKKDFKAERRPAAGQKRKADGADMGDSKSSSSHDTATSAQKMRAKMKEHMAGASEFNLA
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase dbp7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ALG11_XENTR
Sequence: MAGILCLCGMMRLLTALFIPVLIASIGLCLVLVLLFICTRLWIQRKKKQSVEIGKDGKKKRVVAFFHPYCNAGGGGERVLWCALRSLQKRYKDAIYVIYTGDKDVSEEQILNGAAARFNIKLSHPVKFIFLEKRGLVEASFYPRFTLLGQSLGSVVLGWEALTKCVPDIYIDSMGYAFTLPLFKYVGGCQVGCYVHYPTISMDMLSVVRSQNARFNNAAFISNNPVLSRLKLIYYYLFAVIYGWVGSCSDVIMVNSTWTFAHILDLWKCSERTSIVYPPCDVQTFLDINLNQHKDIEEHSIVSIGQFRPEKDHPLQICAFAALLKKKTTEKLKLKLILIGGCRNNEDELRVSELKKLSSELGIPVEFKVNIPFAELKKHLSEATIGLHTMWNEHFGIGIVECMAAGTIILAHNSGGPKLDIVVPYEEHETGFLADSVESYAAAMDYILCLTPEQRLTIRQNARRSVARFSDQEFEANFLASSEPLFM
What are the official names of this protein?
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRMA_PECAS
Sequence: MTPEILPIEDYDDQLAEKTERLRGMMAPFNAPEPAVFRSPVSHYRMRAEFRIWHDGDELYHIMFDQQTKQRIRVDRFPAASELINRLMPEMLAAIQPDPVLRRKLFQIDYLSTLSGEVIVSLLYHRALNEEWQEHARALRDSLTAQGFNLQLIGRATKTKICLDRDYVDECLPVAGRNMIYRQVENSFTQPNAAVNIQMLEWALDATAGSKGDLLELYCGNGNFSLALARNFERVLATEIAKPSVAAAQYNIAANQIENVQIIRMAAEEFTQAMQGVRQFNRLQGIDLTSYQCETIFVDPPRSGLDDETVKLVQAYPRILYISCNPETLSNNLKTLSETHDIRRLALFDQFPYTHHMECGVLLEKRQ
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: THIC_PSET1
Sequence: MSNTAKKSSRRETRAAASEYIYNLTGQPFPNSHKVYVEGTQNNIRVGMREITLSDTYIGGSDENPVYEPNEPLRVYDTSGPYTDPNFKLDVRQGLAKFREQWIESRGDTELLESVTSRFTQQRMADEGLDHLRFEHLPKIRRGKAGKNVTQMHYARQGIITPEMEYVAIRENMGRKKIHAELLAAQHKGESFGASIPDFITPEFVRDEIARGRAILPNNINHPETEPMIVGRNFLVKVNANIGNSSVSSSIEEEVEKMVWSTRWGADTVMDLSTGRYIHETREWVVRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICEILKQYDICFSLGDGLRPGSIADANDEAQFSELRTLGELTKLAWKHDVQVFIEGPGHVPMHMIKANMDEQLKHCDEAPFYTLGPLTTDIAPGYDHITSGIGAAQIAWYGCAMLCYVTPKEHLGLPNKEDVKEGLITYKIAAHAADLAKGHPGAQERDNALSKARFEFRWHDQFNIGLDPERAREYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVREYAKDLEARGIDPANAADTITIKMIDVEAQMKAKSDEFKKTGSEIYHKAI
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PGAM5_DROME
Sequence: MRKLTSFVCGTGAGLAAYYLQRLRDPQTVVQNSWTHSDKPVDPWALWDTNWDCREPRALVRPLRNSQPEEENRYNAELEKAKAKKARHIILVRHGEYLDVGDSDDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREGAPIPPQPPVGHWKPEASQFLRDGSRIEAGFRRYFHRAYPDQEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSGNVSIKYLGDSGFMPAELLTNRIPRDVKNVV
What is the function of this protein?
Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase.  Has apparently no phosphoglycerate mutase activity.
What are the official names of this protein?
Serine/threonine-protein phosphatase Pgam5, mitochondrial, DPGAM5, Phosphoglycerate mutase family member 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: RS8_DEIRA
Sequence: MLSDPIADMLTRIRNATRTHKETVDIPASKFKEELAKLLVREGYVQGVERTRPEGQKFDVLRVTLKYGEKREQVIKHIERVSRPGRRAYVSAENLPRVQRGLGVAVVSTSRGLLPDREARQQGVGGEVVCVLW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: COBT_ECO24
Sequence: MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYTRELAKNGVTLFGVGELGMANTTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVGGFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: TRPB_EDWI9
Sequence: MSLLNPYFGEFGGRFVPQILIPALNQLEAAFVDARDDPTFQTQFNDLLHNYAGRPTALTLCRNLTAGTRTRLYLKREDLLHGGAHKTNQVLGQALLARRMGKTEIIAETGAGQHGVATALACALLGLKCRVYMGAKDVARQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSANYDQAHYLLGTAAGPHPYPTIVREFQRMIGAETRRQILQAEGRLPDAVLACVGGGSNAIGMFADFIDDASVQLIGVEPAGLGIETGQHGAPLSHGRVGIYFGMRSPMMQTAEGQIEESYSLSAGLDFPSVGPQHAHLNSIGRADYVSATDDEALAAFMQLSRQEGIIPALESAHALAHALKLIHQQPEKEQLLVVNLSGRGDKDIFTVHDILQSRGEIQ
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: AHI1_HUMAN
Sequence: MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVPDCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGSFQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSNMLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE
What is the function of this protein?
Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium.  Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Involved in neuronal differentiation.  As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382).
What are the official names of this protein?
Jouberin, Abelson helper integration site 1 protein homolog, AHI-1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium.
Protein: YWRC_BACSU
Sequence: MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVAVQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTSLYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YwrC.
Protein: RL20_SALPB
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.