PharMolix/UniProtQA huggingface dataset:
Protein: YOPD_YEREN
Sequence: MTINIKTDSPIITTGSQLDAITTETVGQSGEVKKTEDTRHEAQAIKSSEASLSRSQVPELIKPSQGINVALLSKSQGDLNGTLSILLLLLELARKAREMGLQQRDIENKATISAQKEQVAEMVSGAKLMIAMAVVSGIMAATSTVASAFSIAKEVKIVKQEQILNSNIAGRDQLIDTKMQQMSNAGDKAVSREDIGRIWKPEQVADQNKLALLDKEFRMTDSKANAFNAATQPLGQMANSAIQVHQGYSQAEVKEKEVNASIAANEKQKAEEAMNYNDNFMKDVLRLIEQYVSSHTHAMKAAFGVV
What is the function of this protein?
Interacts with the target membrane to form channel structures involved either in translocation of YopE into the cytoplasmic space of the target cell or in the cytotoxic effect of the YopE protein.
What are the official names of this protein?
Protein YopD.
Protein: IPT_RALSO
Sequence: MPVRLYLIWGATTTGKTAQSVALARSAGAPVISLDRVQCCHELAVGSGRPSPSELLGTRREYLCEREVSRGVVSAAEANQLLLDKVARYATQERALILEGGSVSLINAMIRDARWSERGEWILRRIPVPGRAAFMAAARKRVREMLDPPPGQAGILDELQGLWGYPRNHAVLEDIDGYRQIIRYANALQVPICRITSIDPNAKALLIERIAQEYWEHALWQEQEFLGIPASWMRADDA
What is the function of this protein?
Transfers dimethylallyl groups to AMP as part of the biosynthesis of cytokinin phytohormones.
What are the official names of this protein?
Adenylate dimethylallyltransferase, Dimethylallyl transferase, Isopentenyl transferase, Trans-zeatin producing protein.
What is the protein family that this protein belongs to?
Belongs to the isopentenyl transferase family.
Protein: NRFA_SALPK
Sequence: MARKTLRARRFFSLIFPFFFITSVYAEQTPVSAKTVTVEAKNETFAPQHPDQYQSWKATSEQSAREDALAEDPRLVILWAGYPFSRDYNKPRGHAYAVTDVRETLRTGAPKTAEDGPLPMACWSCKSPDVALLIQQEGEDGYFHGKWARGGPEIVNDLGCADCHNTASDDFAQGKPALTLSRPYAERAMEAISKPFDKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDEGMKVENMEQYYDAIAFSDWTNSLSKTPMLKAQHPEYETWSAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKASLQKVVAERKQAIHDLKIKVEDQLVHAHFEAKAAWDAGATDAEMKPILNDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGSAMDKAADARTKLARLLATKGITHEIPLPDISTKEKAQKAIGLNMQQINAEKQDFLKTVVPQWEDQARKNSLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GIPR_MOUSE
Sequence: MPLRLLLLLLWLWGLQWAETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQIMYTVGYSLSLTTLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAAAILTRDQLLPPLGPYTGDQAPTPWNQALAACRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIPWVIVRYLRENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRQGWRHRRLRLSLQEQRPRPHQELAPRAVPLSSACREAAVGNALPSGMLHVPGDEVLESYC
What is the function of this protein?
This is a receptor for GIP.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
What are the official names of this protein?
Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACT25_DICDI
Sequence: MECEEVQAIVIDNGSSVCKAGFGGDDAPRTAFPSIVGRPRCTGFIVDMDKKDSYFCKKNSCFMGQKDLYIGDEAQSKRGILNVKYPIERGIITNWNDMEEIWYHTFYNELHVAPEEHPVLLTEPPLNPKANREKMTQIMFETFKTPAIYVANQGVLSLYSTGLTTGIVMNSGDGVSHTVPVYEGYILRQAILSLDLAGRDLTDYMNELLTDRGYYFTTKGEKEIVRGIKEKLSYVALDFEAEMQIASASPALEKSYELPDGQVITIGNERFRCPEALFRPYTGIHETIYNSIMKCDDDIRKDLFGSVVLSGGSTMFPGIVDRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSSFQPRWISKEEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity).
What are the official names of this protein?
Putative actin-25.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: K6PF_METJA
Sequence: MCDIMEIKKFIETIKGTKLFTAYNTNVDAIKYLKDEDVQKLVDEFNHKDIIERMEEYPRIIEEPLDFVARLVHSIKTGKPAEVPIKDDKKLHEWFDRIKYDEERMGGQAGIVSNLMATLQIDKIIVYTPFLSKKQAEMFVDYDNLLYPLVENGNLVLKKVREAYRDDPIKINRIFEFKKGLKFKLNGEEITAKQSTRFIVASRPEALRIEIKDDVRKFLPKIGEAVDCAFLSGYQAIKEEYRDGKTAKYYFERAEEDIKLLKKNKNIKTHLEFASISNIEIRKMVVDYILSNVESVGMDETEIANVLHILGYDELSNNILKDSFIEDVIEGAKILLDKFKNLEVVQVHTIYYILFVCRADNPLSKEELEECLEFSTILASTKAKLGNIRAIDDLHEGLKIPHNKYGDLLKEIAEKFNDNNYKIALSPSRYVEKPKSTVGLGDTISSGAFVYYVSLLNKKRMS
What is the function of this protein?
Catalyzes the phosphorylation of fructose 6-phosphate and D-glucose to fructose 1,6-bisphosphate and D-glucose 6-phosphate, respectively, using ADP as the phosphate donor.
What are the official names of this protein?
Bifunctional ADP-specific glucokinase/phosphofructokinase, ADP-GK, ADP-GK/PFK, ADP-Pfk, ADP-dependent glucokinase, ADP-dependent phosphofructokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECE_RICBR
Sequence: MFKEYKIYKFFEQVKQEAYKVVWPTKKELTASTLVVIVAVFVFSLICLVLDYGIHNIIQILLNIGK
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IF4E1_LACSA
Sequence: MVEEIMKSEEQKLIDVNKHRGVRSDGEEDEQLEEGEIVGGDADTLSSSSSSRPGTAIAQHPLEHSWTFWFDTPSAKSKQVAWGSSMRPIYTFSSVEEFWSLYNNIHRPSKLAQGADFYCFKNKIEPKWEDPVCANGGKWTMTFTKAKSDTCWLYTLLAMIGEQFDHGDDICGAVVNVRARQEKIALWTKNAANESAQLSIGKQWKEFIDYNDTIGFIFHEDAKTLDRSAKNKYTV
What is the function of this protein?
(Microbial infection) Susceptibility host factor required for viral infection by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-1, Ls-eIF4E-1, eIF-4E-1, eIF-4F 25 kDa subunit, eIF-4F p26 subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TIPIN_HUMAN
Sequence: MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR
What is the function of this protein?
Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137).  Important for cell survival after DNA damage or replication stress (PubMed:17116885).  May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725).  Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725).
What are the official names of this protein?
TIMELESS-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS5_BURL3
Sequence: MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRIGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASAVLLAPAKAGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPADIAAKRGKSVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PEPVL_STAAS
Sequence: MWKEKVQQYEDQIINDLKGLLAIESVRDDAKASEDAPVGPGPRKALDYMYEIAHRDGFTTHDVDHIAGRIEAGKGNDVLGILCHVDVVPAGDGWDSNPFEPVVTEDAIIARGTLDDKGPTIAAYYAIKILEDMNVDWKKRIHMIIGTDEESDWKCTDRYFKTEEMPTLGFAPDAEFPCIHGEKGITTFDLVQNKLAEDQDEPDYELITFKSGERYNMVPDHAEARVLVKENMTDVIQDFEYFLEQNHLQGDSTVDSGILVLTVEGKAVHGMDPSIGVNAGLYLLKFLASLNLDNNAQAFVAFSNRYLFDSDFGEKMGMKFHTDVMGDVTNNIGVITYDNENAGLFGINLRYPEGFEFEKAMDRFANEIQQYGFEVKLGKVQPPHYVDKNDPFVQKLVTAYRNQTNDMTEPYTIGGGTYARNLDKGVAFGAMFSDSEDLMHQKNEYITKKQLFNATSIYLEAIYSLCVEE
What are the official names of this protein?
Putative dipeptidase SAS1677.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: PURL_PETMO
Sequence: MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKINESYESENAGYVQIGGKAVVFKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALLDSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGETSFNEIYSTNPLINVMCVGVANKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLIEATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLSESQERMLFLVNPGTEKKVEAICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDILVNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILLSNHNISSKKWIYQQYDYKVETNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAKPLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTPVIGMIGEIKDIKKIVNLKFKDCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVNPMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCILSNRGFKGILDASIEELFGENQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDSISKSVEE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSRA_SHIFL
Sequence: MQTSDTRALPLLCARSVYKQYSGVNVLKGIDFTLHQGEVHALLGGNGAGKSTLMKIIAGITPADSGTLEIGGNNYARLTPVHAHQLGIYLVPQEPLLFPSLSIKENILFGLAKKQLSMQKMKNLLAALGCQFDLHSLAGSLDVADRQMVEILRGLMRDSRILILDEPTASLTPAETERLFSRLQELLATGVGIVFISHKLPEIRQIADRISVMRDGTIALSGKTSELSTDDIIQAITPAVREKSLSASQKLWLELPGNRPQHAVGTPVLTLENLTGEGFRNVSLTLNAGEILGLAGLVGAGRTELAETLYGLRTLRGGRIMLNGKEINKLSTGERLLRGLVYLPEDRQSSGLNLDASLAWNVCALTHNLRGFWAKTAKDNATLERYRRALNIKFNQPEQAARTLSGSNQQKILIAKCLEASPQALIVDEPTRGVDVSARNDIYQLLRSIAAQNVAVLFISSDMEEIELMADRVYVMHQGEITHSALTGRDINVETIMRVAFGDSQRQEASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS13_BACP2
Sequence: MARIAGVDIPRDKRVVISLTYVFGIGRTTAQQVLKEAGVSEDTRVRDLTEDELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNTKNNARTRKGPRRTVANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YIDD_BACC3
Sequence: MKQIFIGIIRFYQKFISPMTPPTCRFYPTCSHYGLEAFQKHGAFKGFWLTCKRILKCHPFHPGGFDPVPDKKDDKVNS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RSMH_CAMC1
Sequence: MQSPHISVLLDEVLSFFKDLRGNFIDCTLGYAGHSSAILSQNENLNLIACDKDIEAINFSLKKLEPFGSRVKIYKSNFSELISKLSSDEISNVRGILADIGVSSLQIDKDDRGFGLGSSALDMRMDKERGFSAYDVVNGYSFDELVRIFRDYGELKNASGIANKIINARNLGEITSAKELANIIGIAQIKGRGVSPAILAFQAIRIEVNGELDELTNLLDSIEKGGFKDCLVTIITFHSLEDRIVKERFKKWANSCICPPGIYRCECGNNHELGEILTKKPLTASQSELAQNSRSKSAKLRVFKIKG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB1_MYCBO
Sequence: MAKRLDLTDVNIYYGSFHAVADVSLAILPRSVTALIGPSGCGKTTVLRTLNRMHEVIPGARVEGAVLLDDQDIYAPGIDPVGVRRAIGMVFQRPNPFPAMSIRNNVVAGLKLQGVRNRKVLDDTAESSLRGANLWDEVKDRLDKPGGGLSGGQQQRLCIARAIAVQPDVLLMDEPCSSLDPISTMAIEDLISELKQQYTIVIVTHNMQQAARVSDQTAFFNLEAVGKPGRLVEIASTEKIFSNPNQKATEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PDXS_CLOBM
Sequence: MEKRYELNKNLAQMLKDGVIMDVVNPEQAKIAEEAGAVAVMALERVPSDIRKQGGVARTSDPKMIKEIINAVSIPVMAKVRIGHFVEAQILEAIGVDYIDESEVLTPADDLFHINKKDFKVPFVCGARNLGEALRRIGEGASMIRTKGEAGTGNVVEAVRHMRTISSEMRKLQLTPKEELMTVAKEMGAPFNLIEYVAEKGRLPVINFAAGGIATPADAALMMQLGCDGIFVGSGIFKSDNPEKRAKAIVKATTYFKDPEVLAKASENLGGAMLGLEISKLETEFAERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: NQOR_SHIDS
Sequence: MTKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ZIPA_SHEB8
Sequence: MEDLQLVLFVLGAIAIVAVLVHGFWSIRRQQPKSLKDSPMGNFYKKQAEKGESIPKRIDAEGFDADGIGAVRVRKAGELAPNNETPTANPYLKQEVKLETKPQELTSPEFKAELKQGLKPELKVEAKHEPIPAQPDFSLQPPVAKEQHRGPKVSRQEPVLGTQVPQMGQSHAAIVAQKAAEQEQALRAAPQQSALFEENEHQADHQEEAFVEQAAEDELGEPRDVLVLHVVAKDGQQLNGAELLPCFLTLNFKYGDMNIFHRHVDNAGNGKVLFSIANMLKPGVFDPDNMEQFSTQGVVFFMTLPCYGDALMNFSIMLNSARQLAEEIDAVVLDGQRLPWGEFTKQDYLHRIRANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: SYRB2_RHIME
Sequence: MADESNTGSIAAAVAPNADVKAPAAKKKRSPRRQKAVAEPRRAVSETPAAKPRRYSEQQRKEKLKLIETQVTEGKVTLKDAIKSAGISEQTYYQWKRTVKPVEQKAEKRLPTGEELADLVRLEEENQRLRKLLAEKLRAENADLRKRLGLD
What is the function of this protein?
Seems to affect the transcription of cya3.  May be negatively autoregulated.
What are the official names of this protein?
Probable transcriptional regulator syrB2.
What is the protein family that this protein belongs to?
Belongs to the SyrB family.
Protein: RS11_SHESA
Sequence: MAKVPSRSPRKRVRKQVADGMAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAGAAAQDYGLKNLEVFVKGPGPGRESAIRALNAVGYKITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MMP13_RABIT
Sequence: MQPGVLAACLLLSWTHCWSLPLLNSNEDDDLSEEDFQFAESYLRSYYHPLNPAGILKKNAAGSMVDRLREMQSFFGLEVTGKLDDNTLAIMKQPRCGVPDVGEYNVFPRTLKWSQTNLTYRIVNYTPDLTHSEVEKAFKKAFKVWSDVTPLNFTRIHNGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPARDLIFIFRGKKFWAPNGYDILEGYPQKLSELGFPREVKKISAAVHFEDTGKTLFFSGNQVWSYDDTNHTMDQDYPRLIEEEFPGIGGKVDAVYEKNGYIYFFNGPIQFEYSIWSKRIVRVMPTNSLLWC
What is the function of this protein?
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN.  Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen.  Can also degrade collagen type IV, type XIV and type X.  May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2.  Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification.  Required for normal embryonic bone development and ossification.  Plays a role in the healing of bone fractures via endochondral ossification.  Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2.  Plays a role in keratinocyte migration during wound healing.  May play a role in cell migration and in tumor cell invasion (By similarity).
What are the official names of this protein?
Collagenase 3, Matrix metalloproteinase-13, MMP-13.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: ACDH3_DECAR
Sequence: MNKKLKVAIIGPGNIGTDLMIKIMRHGEHLEMGAMVGIDPQSDGLARAQRMGVATTHEGVEGLTRLPVFADIDIVFDATSAGAHVRNDAFLRSLKPNIRMVDLTPAAIGPYCIPVVNGAAHDEALNVNMVTCGGQATIPMVAAVSRVAKVHYGEIIASISSKSAGPGTRANIDEFTETTSKAIEAVGGAAKGKAIIILNPAEPPLIMRDTVYCLSELVDEDEIAASVAQMAADVQKYVPGYRLKQKVQFDIIPASRPINIPGVGQRMSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAAKTTAERMAARILSAA
What are the official names of this protein?
Acetaldehyde dehydrogenase 3, Acetaldehyde dehydrogenase [acetylating] 3.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: AROQ_VIBC3
Sequence: MTAKSRILVLNGPNLNLLGLREPTHYGSQTLEQIVATLRDQAQKADIELEHLQSNREYELIEAIHQAFGKVDFIIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHAREPFRHHSYLSDKAQGVICGLGAQGYEFALSAAIRALQAKQ
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SNTA1_HUMAN
Sequence: MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA
What is the function of this protein?
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins.  May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex.  Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse.  Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
What are the official names of this protein?
Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, TACIP1, Syntrophin-1.
What is the protein family that this protein belongs to?
Belongs to the syntrophin family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Protein: UL92_HHV6Z
Sequence: MEMALPRKYDRVTGRILTHKNNQMCTTECSQMYNLHNPITFELGLGNVFVCMRCLTVHHCDMQTDCTIVNTHEGYVCAKTGLFYSGWMPTYADCFLEPICEPNIETVNVVVVLLSYVYSFLMENKERYAAIIDSIIKDGKFIKNVEDAVFYTFNAVFTNSTFNKIPLTTISRLFVQLIIGGHAKGTIYDSNVIRVSRRKREDSLLKKMRLEYGNALIL
What are the official names of this protein?
Protein U63.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
Protein: HIS6_PHOLL
Sequence: MLAKRIIPCLDVRDGQVVKGIQFRHHEIIGDIVPLAQRYATEGADELVFYDITASSDGRVVDKSWITKVAEVIDIPFCVAGGIKTVEDAGQILSFGADKISINSPALTDPTLITRLADRYGVQCIVVGIDTWFDESTGRYQVYQFTGDEKRTKATQWQTLNWVKEAQHRGAGEIVLNMMNQDGVRNGYDLTQLKQVRDVCHVPLIASGGAGAPEHFLDAFKQANVDGALAASVFHKHIINICELKQYLSQQGVEIRTC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.