PharMolix/UniProtQA huggingface dataset:
Protein: GUAC_STAA9
Sequence: MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKNHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPGETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIFNGDRD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: RL28_ECO8A
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLAELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: IF5A2_SCHPO
Sequence: MGMFIQKEHKPTMAEEEHVDFEGGEAGASLTFPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHIVALDIFNGRKYEDMSPSTHNMDVPVVKRDEYQLVNIDDGYLNLMTTDGTTKDDVRLPEGELGNEIEEGFEEGKDLIITVVSAMGEEIALACRDAPSA
What is the function of this protein?
mRNA-binding protein involved in translation elongation.  Has an important function at the level of mRNA turnover, probably acting downstream of decapping.  Critical for the efficient synthesis of peptide bonds between consecutive proline residues.  Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity).  Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.  Functions as a regulator of apoptosis (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-2, eIF-5A-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRMC_BIFLO
Sequence: MLITDIINQASSQLREAGIETPEHDAKLLLAEAAGVELRDVDRALLMGEELGTTGQLAVFRAMLDRRAKREPLQYITGHAPFRYLDLKVGPGVFIPRPETETVVQAGLDWLTKNGMIHPCVVDLCAGSGAIGLSVVSEVPGSQVWAVELSPNTAEWTRRNLSETAKKYPSIASNYHLEIADATSFATLAQLDGTVDIVITNPPYVPQTDIPEQPEVRDWDPELALYGGSMDGTLIPERIIERACRLLKPGGVLVMEHDVTQGDRLVAFARATGFAAASTGQDWTGRDRYLFAVS
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: UBIE_CUPTR
Sequence: MSETHFGFEKVDETEKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAGVRPGHKVLDIAGGTGDLAKAFAKQAGPTGQVWLTDINESMLRVGRDRLLNKGIVTPVALCDAEKIPFPDNYFDLVTVAFGLRNMTHKEAALAEMRRVVKPGGKVMVLEFSKVWKPLEKAYDVYSFKVLPWLGQRVAGDAPSYRYLAESIRMHPDQVSLVRLMEHAGLENVEYFNLTAGVVALHVGRKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: TRM1L_HUMAN
Sequence: MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW
What is the function of this protein?
May play a role in motor coordination and exploratory behavior.
What are the official names of this protein?
TRMT1-like protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: SCAS1_HUMAN
Sequence: MFQVFKPHAGEDYKYPRETETIWSHPYVVEGSHKSPLESLSLHGCLAAMAPSITSSEDSSPSQRDKKDLSLDLLLTRKKRSQGLHWSHWQGLNHMSIRIHTPEQGSPSLGQNWSWGNRKEKGVAQRQVPTTGTHSFFHCTSEGNKEKPHHF
What are the official names of this protein?
Putative uncharacterized protein SCP2D1-AS1, SCP2D1 antisense RNA 1.
Protein: RL5_PHOPR
Sequence: MAKLHDYYKETVVKELVEKFEYKSIMQVPRIEKITLNMGVGEAINDKKLLENAAADMTAIAGQKPLITKARKSVAGFKIREGYPIGCKVTLRGERMWDFFERLISIAVPRIRDFRGLNPNSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTSAASDEESKALLSAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: AGRF1_MOUSE
Sequence: MRIGLLWLVPLFTLTEGTDGFLQQKNDGRRTKEIVSMVEERHPVHEYEVLLQVTYRDPEEKRELKRFLKLLKSPSPSLRGPSKIIRVKATTYCRSRKGFLECACEDSYTWFPPSCLDPQNCCLHTTGPVPSCNCSLRGLRQSINFCERAKVWGTFEIDEKFPEDLWNSSSDVYAHYTVGIENQLKEAYRRVHGFESVRVTQFRKGSIVVGYEVTGSTSPPELLFAIEQEAEKAQEALRRQFPVKYGSFRVFGKAPCNSISFGFGSENDEYTVPCSSGFTGSMTVRCQSSGWQITRESCVLSQLEELKKELRMIAGKITEAGVASLVQNLSTILLQSPSTTVGNLGSVVSLLSNISSLSLANSLTVSNLTLMNVINIADHILDSASITNWTILLQDAKDASSQLLKTLESISSLIPSMALPLNFSGKFIDWKGTPVTQIQSTRGYNYQMEMRQNASLPIRGHVFIEPDQFQKSHPKTIISMASLTFGDILPITQRGNAWVNGPVISTLIQNYSISEIFLNFSKIKGNLTQPRCVFWDFSQLQWSNAGCQLVNETLDTVLCRCSHLTSFSMLMSPFVPSSVVPVVKWITYIGLSISIASLILCLIIESLFWKQTKRSQTSYTRNICLVNIAVSLLIADVWFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWMLVLGILLAYRIILVFHHMALTTMMAIGFCLGYGCPLLISIITLAVTQPSNSYKRNDVCWLNWSDKSKPLLAFVVPALTIVAVNLVVVLLVLRKLWRPAVGERLNQDDKATAIRMGKSLLVLTPLLGLTWGFGIGTMANSHNLAWHVLFALLNAFQGFFIFCFGILLDTKLRQLLSNKLTTLSSWKQTSKRNASDTVTQPKCLRTFNILQHRGMYALSHTGDSSSDITLTQFLSTE
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Adhesion G-protein coupled receptor F1, G protein-coupled receptor 110.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VAPC5_MYCBO
Sequence: MILVDSNIPMYLVGASHPHKLDAQRLLESALSGGERLVTDAEVLQEICHRYVAIKRREAIQPAFDAIIGVVDEVLPIERTDVEHARDALLRYQTLSARDALHIAVMAHHDITRLMSFDRGFDSYPGIKRLA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.
What are the official names of this protein?
VapC ribonuclease Mb1869c, RNase Mb1869c, Toxin Mb1869c.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: NADK_ACISJ
Sequence: MKPIFRRVAVIGKYPGPGAVSASDSARQIIESIAQFVTQQDCELTLEAETAAHTGLTQYHTLDVEGIGRQCDLCLVVGGDGTMLGVGRRLAGYGTPLVGINQGRLGFITDIPLEGYQDALTPILHGDYEEDVRPLMQACVMRSGECVFEALALNDVVVNRGSTSGMVELRVEVDGVFVSNQRADGLIVASPTGSTAYALSAGGPMLHPSIPGWVLVPIAPHTLSNRPIVLSDATEVAIEVAGGRDISANFDMQSLASLQHGDRILVRRSAHRVCFLHPRGWSYFATLRKKLGWYEGGS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMFF_BACSU
Sequence: MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTKRALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYLKDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLRLIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQSAIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPALQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSIIAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDFLANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS
What are the official names of this protein?
Probable inactive metalloprotease YmfF.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
Protein: CPLX2_HUMAN
Sequence: MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTVLKYLPGPLQDMFKK
What is the function of this protein?
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons.  Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles.  Also involved in mast cell exocytosis (By similarity).
What are the official names of this protein?
Complexin-2, Complexin II, CPX II, Synaphin-1.
What is the protein family that this protein belongs to?
Belongs to the complexin/synaphin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Presynapse. Nucleus. Perikaryon. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.
Protein: Y871_RICPR
Sequence: MLLYRKYFIKNILPLLIIVTFSVTSIVWITQILKLLYLFDKGIKVIDFFNLVVLVLPTLLFILLPIITVIAVLYIYNNLKVERQLIILQTSGVNNIQLALPALYVALTIMLLAYYISSTILPLSHINLKSRLNFIKNNYISSMIEEKTFNKITKNITVFIDKKLTGNIMNGIIIFDNRNADNPSVVFAGSGTLNIYGNNPIFELNKGLRQEYDANGNLTQLTFDSLMIKLQNNSSLTSQRTQNNKEANEYYISELLTPSHDLVITKKIKLIAEAHQRIIWPLYNFVLPCLALAVFLRYPYSKKTTFMPVLFSALTVLFVTAIHFILQNFASKNLDFIFACYFNLLVALTIGLYLLVHKRI
What are the official names of this protein?
Uncharacterized protein RP871.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IGS23_HUMAN
Sequence: MRAKPQSPLPRNPVPAWSPPTTTTDPMLEKDAAGGDFPANLVLQLMPLKTFPAAIRGVIQSELNYSVILQWVVTMDPEPVLSWTFSGVPCGMGEKLFIRRLSCEQLGTYMCIATNSKKQLVSEPVTISLPKPIMQPTEAEPMEPDPTLSLSGGSAIGLLAAGILGAGALIAGMCFIIIQSLRTDRQRIGICS
What is the function of this protein?
May be involved in osteoclast differentiation.
What are the official names of this protein?
Immunoglobulin superfamily member 23.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SIR_PEA
Sequence: MTTSFAAAALRDPKLQIPNYHGLRSSSAASSLSRNALSVPSSTRSSSLIRAVSTPAKSETATEKKRSKVEIFKEQSNFIRYPLNEDMLTDAPNLSEAATQLIKFHGSYQQYNRDERGSRTYSFMIRTKNPCGKVSNQLYLTMDDLADQFGIGTLRLTTRQTFQLHGVVKKDLKTVMGSIIRNMGSSLGACGDLNRNVLAPAAPIVSKDYLFAQETSENIAALLTPQSGFYYDVWVDGERFMSAEPPEVIQARNDNSHGTNFTDSPEPIYGTQFLPRKFKIAVTVPTDNSVDILTNDIGVVVVTGDGGEPQGFNLYVGGGMGRTHRMETTFPRLAEPLGYVPKEDILYAVKAIVVTQRENGRRDDRRYSRMKYLIDSWGIDKFRNVVEEYYGKKFEPFRSLPEWEFKSYLGWHQQGDGGLFCGLHVDNGRIAGKMKTALREVIEKYHLNVRLTPNQNLILTDIRAAWKRPITTILSQAGLLLPRYVDPLNITAMACPAFPLCPLAITEAERGIPSILKRIRDMFEKVGLKYNESVVVRITGCPNGCARPYMAELGLVGDGPNSYQIWLGGSSNQTSIARSFMDKVKPQDLEKVLEPLFYHWKQKRQSKESFGDFTVRLGFEKLKEFIEKWEGPAVPPTRHNLKLFTDKDTYEAMDGLAKLQNKNAHQLAMEVVRNYIASNLNGKGE
What is the function of this protein?
DNA-binding protein that binds to both double-stranded and single-stranded DNA without significant sequence specificity to reversibly repress the transcriptional activity of chloroplast nucleoids by promoting DNA compaction and possibly regulate DNA replication.
What are the official names of this protein?
Sulfite reductase [ferredoxin], chloroplastic, PsSiR.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma, chloroplast nucleoid. Plastid, chloroplast stroma. Plastid stroma.
Protein: ISPF_CARHZ
Sequence: MMIRIGFGYDVHPLVEGRKLIIGGVEIPFTKGLLGHSDADVLYHAIADAFLGSLALGDIGQLFPDNDERYRGIDSGLLLQEVYRRVRERGYCLNNLDAVIVAQKPKLLPFIQKMRENLAVLLNTAIENISVKATTTEGLGFAGREEGIAAYAVITVKEVLENG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: XYXT1_ORYSJ
Sequence: MKAAVRSKKSKGSFCHPPLLLLIVAIQFLVIYSPTLDQYMVMLTTGKPGFPSMLIDGRRSFKQVDEFIPEPHLRCDFRDNRSDVCEMEGAIRILGRTSEVFLVAPSLASISGGGGGVNATGVDANATRWKIQPYTRKGESRVMPGITEVTVRLVTADEAPPCDEWHDVPAIVYSNGGYCGNYYHDFNDNIIPLFITSRHLAGEVQLLVTQKQRWWFGKYREIVEGLTKYEPVDLDAEQRVRCYRRATVGLHSHKDLSIDPRRAPNNYSMVDFKRFLMWRYALPREHAIRMEEEDKSKKPRLLVINRRSRRRFVNLDEIVAAAEGVGFEVAAAELDAHIPAAASAVNSYDAMVAVHGSGLTNLVFLPMNAVVIQVVPLGRMEGLAMDEYGVPPRDMNMRYLQYNITAEESTLSEVYPRAHPVFLDPLPIHKQSWSLVKDIYLGQQDVRLDVRRFRPVLLKALHLLR
What is the function of this protein?
Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:29325159).  Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone (PubMed:29325159).  Catalyzes the addition of 2-O-xylosyl side chains to the xylan backbone (PubMed:29325159).
What are the official names of this protein?
Beta-1,2-xylosyltransferase XYXT1, Xylan xylosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 61 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: TOTM_DROYA
Sequence: MNPTVYLSCLVVFSLFYLGKAQAENDDEFATEKQRLLRVYGDSSVDEATRYRNVDDLVKFYDKYSTLLPLKPDLTQRAQDLVRRYKEESARVVLVDGAPAQGGFWLPLVKLLIVQLGVEIASEGFKRAIES
What is the function of this protein?
A humoral factor that may play a role in stress tolerance.  Requires Mekk1 expression in the fat body to regulate response to septic injury and consequent immune response (By similarity).
What are the official names of this protein?
Protein Turandot M.
What is the protein family that this protein belongs to?
Belongs to the Turandot family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOA_RALPJ
Sequence: MNLEAYFPVLLFIVVGVGLGLALMTIGRVLGPNNPDPDKLSPYECGFEAFEDARMKFDVRYYLIAILFILFDLETAFLFPWGVALREIGWPGFFAMGVFLLEFLVGFVYIWKKGALDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NSE2_HUMAN
Sequence: MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKLLVEKKFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIVTQSQTNFTCPITKEEMKKPVKNKVCGHTYEEDAIVRMIESRQKRKKKAYCPQIGCSHTDIRKSDLIQDEALRRAIENHNKKRHRHSE
What is the function of this protein?
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316).  Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316).  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316).  The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526).  Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850).  Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526).  SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526).  Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785).
What are the official names of this protein?
E3 SUMO-protein ligase NSE2, E3 SUMO-protein transferase NSE2, MMS21 homolog, hMMS21, Non-structural maintenance of chromosomes element 2 homolog, Non-SMC element 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSE2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Nucleus, PML body. Note=Localizes to PML nuclear bodies in ALT cell lines.
Protein: CAPSD_BPFR
Sequence: MASNFEEFVLVDNGGTGDVKVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSANNRKYTVKVEVPKVATQVQGGVELPVAAWRSYMNMELTIPVFATNDDCALIVKALQGTFKTGNPIATAIAANSGIY
What is the function of this protein?
Acts as a translational repressor of viral replicase synthesis late in infection.  This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the Levivirus capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=The shell is composed of 178 copies of the capsid protein and 1 copy of the maturation protein.
Protein: RL31B_LACCB
Sequence: MKQGIHPDYHPVVFMDSATGFKFISGSTKTSKETVKWEDGKEYPLVRVEISSDSHPFYTGKQKFTQADGRVDRFNKKYGLDKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: SWET1_RAT
Sequence: MEAGGVADSFLSSACVLFTLGMFSTGLSDLRHMQRTRSVDNIQFLPFLTTDVNNLGWLSYGVLKGDGTLIIVNTVGAVLQTLYILAYLHYSPQKHAVLLQTATLLAVLLLGYGYFWLLVPDLETRLQQLGLFCSVFTISMYLSPLADLAKIIQTKSTQRLSFSLTIATLLSSTSWSIYGFRLKDPYITVPNLPGILTGFIRLVLFYKYPPEQDTKYRLLQT
What is the function of this protein?
Mediates sugar transport across membranes.  May stimulate V(D)J recombination by the activation of RAG1 (By similarity).
What are the official names of this protein?
Sugar transporter SWEET1, RAG1-activating protein 1, Solute carrier family 50 member 1.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=May also localize to the endoplasmic reticulum.
Protein: GARA_MYCS2
Sequence: MTDKDSNLGADQSEDVTVETTSVFRADFLNELDAPAAAGTEGAVSGVEGLPSGSALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLEGGEFQVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVFLTGPKSDDSGSNA
What is the function of this protein?
Involved in regulation of glutamate metabolism.  Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd and Gdh.
What are the official names of this protein?
Glycogen accumulation regulator GarA.
Protein: HSPQ_SALPC
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPEYSLDEPSPDELAVNDELRAAPWYHVVMEDDDGQPVHTYLAEAQLRSEMRDEHPEQPSMDELARTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_PYRIL
Sequence: MLPQEVENILDVVIRHNTWRRKETINLIASENVMSPLAELVYINDLAGRYAEGIVGSRYYQGVRYVDILEDALSKKFANVLGARFVDVRPISGTIANLAAYFALVPEGGTVASLPIKYGGHISHNTVGGLKALRLKAVELPWDLENFNIDVDAARKLIEEKRPNLIILGASLYLFPHPVKEIAEVAKTVGAYVLHDSAHVFGLIVGGAFPNPLREGAHLTTASTHKTFPGPQGGVIATVLDEEKNSQIQRAVFPTFTSNYHLHRYAATYVTLVEMEVFGREYATRIVENARALAEALAAEGVPPVAERQGYTKTHQVAVDVSKFGGGDKVAALLEEANIIVNKNALPWDKSVLKPSGIRIGVQEMTRFGMGKDEMREIARFIARVLRGEDVNNIKRDVVEFRKSYLEIKYGFKISRDIVDKIFHSLNLYT
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_BURO1
Sequence: MGTNDALTSTEDAVTAGANDAPLPAPPEPPRKARRATSRTSDFRVAEQPAFVLHSYPYRETSLIVDVLTRDHGRLALVAKGAKRPHSALRGVLQTFQPLLLSWSGKSEVRTLTGAEWVGGMLPLGGDGLLCGFYANELLVKFCAREDPQPPLFNHYVLTLTRLAHGEPAVQVLRSFERVLLRETGYAMALNRTVARRAVEPERRYVFDPERGVRNADDDVPSHWPVITGQTLLDMEQDDYHRAQTVAQSKTLMRFLLNTYLGGTPLATRQILIDLQNL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RS5_DESVM
Sequence: MEQNEFGLVEKIVYLNRVAKVVKGGRRFSFSALVVVGDAKGAVGFGLGKAQEVPEALRKATERAKKDMVQIPLVDGTLPYEILGEFGAGCVMLKPASKGTGIIAGGAVRAVMEAVGVTDVLAKAIGTNNPHNVLRATMAGLTSLRSAEYVSQLRGMKLEAPRK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.