PharMolix/UniProtQA huggingface dataset:
Protein: VE4_HPV58
Sequence: MDDPEVIKYPLLKLLTQRPPRPPTTKVHRGQSDDDSIYQTPETTPSTPQSIQTAPWTVDHEEEDYTVQLTVHTKGGTCVVLKFHLSCI
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: A100_SSV1
Sequence: MVSPQTRKEEELLEKQNSVFYLLTLGRKPYGSYLHIKIELDEDEKLEKEIYADNIKLENELRQLKRLYEVYQSVEIDDAQKAIQKEALLTIAKILSVFDF
What is the function of this protein?
This protein may be involved in virus assembly.
What are the official names of this protein?
Uncharacterized protein A-100.
Protein: NODI_RHIME
Sequence: MAQEAPRWLEPSPFEWKDQTGLAVKTAIPGAKPTVAIDVASVTKSYGDKPVINGLSFTVAAGECFGLLGPNGAGKSTITRMILGMTTPGTGEITVLGVPVPSRARLARMRIGVVPQFDNLDLEFTVRENLLVFGRYFRMSTREIEAVIPSLLEFARLENKADARVSDLSGGMKRRLTLARALINDPQLLILDEPTTGLDPHARHLIWERLRSLLARGKTILLTTHIMEEAERLCDRLCVLEAGHKIAEGRPHMLIDEKIGCQVIEIYGGDPHELSALVSPHARHIEVSGETVFCYASDPEQVRVQLDGRAGVRFLQRPPNLEDVFLRLTGRELKD
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit is responsible for energy coupling to the transport system.
What are the official names of this protein?
Nod factor export ATP-binding protein I, Nodulation ATP-binding protein I.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YLA1_LACAI
Sequence: EFYSYKYRNFSTMIIIPAAIFVLLLFVGSFFAVRQNTVSSVGVVEPTVVIKRKNVNYDEGQVVTKYGQKWVAHVDQGGGISLMPVMKPKSKVKIVTYVTSDKISTIKKGQSLTFSVPTGDGLTRHLTGKVEKIGVYPVNMNKQNIYEIISTAKVNDENIKYGMQGNVTIMTGRSTYLKYLLDKVRNNK
What are the official names of this protein?
Uncharacterized protein in laf 5'region, ORF1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: AROQ_BRUC2
Sequence: MTKTVFVLNGPNLNLLGKREPGIYGVATLDDIEASCKREAGQLELQIDFRQSNHEGDLVSWIQEAGEKNAYVLINPAAYSHTSVAIHDAIRSARVTVVEVHLSNIHAREAFRHHSHVSAVAKGVICGFGAEGYLLGLRALAAIAKEEENNGQSIKGA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL3_MYCTU
Sequence: MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: SYV_STRM5
Sequence: MTQLASSYDPKSFETDLYEAWEKAGHFKPSGTGEPYTILLPPPNVTGTLHMGHAFQQTLMDALVRYHRMRGYDTLWQVGTDHAGIATEMVVSRNLALEGKGETRDSLGREGFIGKVWEWKQQSGDIIERQMRRLGTSADWSRSTFTMDPQPSAAVNEAFVRWYEQGLIYRGQRLVNWDPVLKTAISDLEVESAEEDGFLWSIAYTLDDGLSYEHVERDADGVETLRETRDYLVVATTRPETLLGDTAVMVHPEDARYAHLIGKSVVLPLTGRRVPVIADDYVDRAFGTGVVKVTPAHDFNDYEVGVRHSLPMINLFTPVAALNENAPERFQGLDRYAARKAVLAELEDLGILVETKAHKLQVPRGDRTGQVIEPYLTDQWFVKMDDLAKRGLELVEDGSISFVPPNWINTYRHWMNNIQDWCISRQLWWGHRIPAWFDEATGSCYVGRSEEEVRAKHSLGSDVVLNQESDVLETWFSSQLWPFSTLGWPNEQAMAERGFDRYLPSSVLITGFDIIFFWVARMIMATDNLVGKIPFKDVYFTGLIRDGQGQKMSKSKGNVLDPLDIIDGISIDDLVAKRTGGLMQPKMVEKIEKATRKEFPDGIAAHGADALRFTIAALATHGRDIKFDMNRAEGYKNFCNKLWNASRFTLMNTEGAAFTGMPTPRTDAERWILSRLAAVSSEAQGHYANYRFDLLAQCLYEFAWNEFCDWFLELSKPALNGADAADAESTRHTLLYVLEALLRLLHPLTPFITEQLWQQLAPRLGLAETTLSLRPYPTAAEFEGDFAQAEADVEWLKAVISAVRRVRSELNVAPSKQVPLRLQAGLEQDRVRIERFSASLSFLLKLDSIQWLAEGESAPPAAAAIVGELKLLVPLEGLVDLDAERVRLDKEIARVEVEKEKSETKLAKFTDKVPPAVVEQERVRLVDWNTQLAGLREQRAKL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2B_METKA
Sequence: MAASERNTGKFTEECPACGSAEIVFDEERGEYVCANCGLVTEDPVIDPGPEWRHFNPDQRQRRSRTGEPVKLRLPDKGISTIIDRELRDSGGKKNPRMRRIRTWDARIKVSGSRERNFFQAFLELENLASKLQLPESVRELAASIYRKAYKEGIVRGRGIESVLGAAVFAACKEARVPRTAREIAEALGVSDENEILRAYRVLQRRLNLKQKPTEPSDHLPRFASKLGVSENVQAKAQEIIEKAKEKGITVGKGPAGVAAAALYIASILEGERRTQKEIAEVARVTEVTIRNRYKEICEALGIELHP
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: CL161_CAEEL
Sequence: MYRRTTLWFLLLFQPILVFAQNRTELYECKIGTVNPLASTSLNACFKLYNTPKSFQAARRYCVSLGGQLADKINKDDSSLYSANADLEVANSTKFWVGASNLKCNIAWENGGEIEFNDMWAPESRYYGVAIDKMSIGGLWHTVPVGQKLPFVCTFQGKSNEAGPAPVHAMRAPAKKRVPKVEKPEEKDIDESLNAALSDKKEKKEVASDKKKESKKDEEDINESMNAALSDERKKSASLASSDKKESSKKDESSDEANLSASQVANAEMSASISASSANSSSDESSDEAYDSAEIEMRKKIGKTVIAMKSQEMASQSDDYDKYTEEDLLSAAASLIGGYILNAHWADSRTTNTSSFDSQTDEETLNMMMAIAEQIAMTMRSSKRRESSSSNTDSESASISESSQASEQAVMAAAMSAKSSKKSESSSKDESEDSASLNLEQKASAAASAALASKSKSDSSDQSKDQKSANVALAVVSENKHPTKKPEDPKSTKTTTEEPDIDESLNAALANQRSTTTKNSDLTTIITTVKPNALPIAIVAKQSEKDPACPAEWTQFNTNATAPALCFKRYEKPMNFEDARLFCVGKGGHLASIHNERQLLLLSALLHNNGPDALSDQTWIGLNRIHQKYYVYEDETAMDFTRWLPGAPNINDCTVFTGNELPNYPHKGTQYKFGDFPCEEVQKSVLCEVTLGKDKLKSQTTCQDGWSYYSHDGTAKNGKCYKRIDQSKKFSEAREVCKVENSYVASVQNEGEARFVSALVQTEKNYTVDEQTWIGYVKYDRDFGWEDGNKGLQFDPWTEKMPRQKKCTVFTGNEIHENCRSQFRFVSVDCNKTQRSVLCSKPPMKNGTPFVYKDTDNSSKKI
What are the official names of this protein?
C-type lectin domain-containing protein 161.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTL_ECO8A
Sequence: MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMAMMGIAVLMLSLFILKETRPASPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
What is the function of this protein?
Confers resistance to chloramphenicol.
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIPR1_MOUSE
Sequence: MMSLSVRPQRRLLSARVSRSQSFAGVLGSHERGPRSFTVFSPPGPPRKPLVLSRVSRMFSVAHPAPKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREARDSLAEATRGHREYTESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARHSTPKPLVQQPEPLPVQVAFRRPESLTSGSMDEEPAMTPSLVNGHAPYSRTLSHISEASVDAALTEAVEAVDSQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLTSTGSVPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAKMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLPCSHPASPPYTKADPTASCTSYQSLASSGSKPLTSPAPDSPEQIPKSPSSSPSSSAPEPQHSEHNLAAVAQAPVPEATGGAGDRRLEEALGTLMSALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNDDEDEDNDGPGDRHTSSPEVVAEDRLDSSNGQSLSTGCSALDATLVQHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVFQEVCERSKLWGNSATSAQEVVQFSASRPGFLTFWDQCTEGLSPFICSVERVLLTFCSQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPQPGPGEQFTIFQFWSYVEALDSPSMDAYVTETAEEVLLVQNLNSDDQAVVLKALRLAPEGRLRKDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRQLEESLDALPCIFGPSSMASTAF
What is the function of this protein?
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration.  Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation.  Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
What are the official names of this protein?
Rho family-interacting cell polarization regulator 1.
What is the protein family that this protein belongs to?
Belongs to the RIPOR family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Note=Localizes to the podocyte major processes and cell body (PubMed:17251388). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (By similarity).
Protein: OPGH_PSEPG
Sequence: MSNSNARPVSLGEYLAHLPLSDEQRAELASCSSFSELHQRLAADPAAGPAEAVQASVGPRLTVGSAAELEDAEMLGVDGSGRLCLKIAPPIKRTKVVPEPWRTNVLIRMWRRMTGRPNAPQPPKRELPPARWRTVGSIRRYILLALMIGQTIVAGWYMKGILPYQGWSFVDLDEILSQSLWDTVVQVWPYALQTSILILFGILFCWVSAGFWTALMGFLELLTGRDKYKISGSSAGNEPIAPEARTALVMPICNEDVPRVFAGLRATFESVAASGNLDRFDFFVLSDTNDTDIAVAEQQAWLDVCRETKGFGRIFYRRRRRRVKRKSGNLDDFCRRWGGEYKYMVVLDADSVMSGECLSSLVRLMEANPDAGIIQTGPKASGMDTLYARMQQFATRVYGPLFTAGLHFWQLGESHYWGHNAIIRMKPFIEHCALAPLPGKGAFAGAILSHDFVEAALMRRAGWGVWIAYDLPGSYEELPPNLLDELKRDRRWCHGNLMNFRLFLVKGMHPVHRAVFLTGVMSYLSAPLWFLFLVLSTALLATNTLMEPQYFIEPYQLYPLWPQWHPEKAVALFSTTIVLLFLPKLLSVILIWAKGAVEFGGRIKVTLSMLMEMLFSMLLAPVRMIFHTRFVLAAFLGWAATWNSPQRDDDSTPWSEAVRRHGPQTLLGIAWAALVAWLNPSFLWWLAPIVGSLVLSIPVSVISSRTRLGLAAKDEKLFLIPEEYATPQELLATDQYTHENRWHALHDGFVRAVVDPRQNALACAMATARHGQAAPIEALRAERVAKAMEVGPKGLDLNTRLALLSDPVALTRLHEQVWAEHNAAWIDVWRASIKNDPHSPLLPLHPESEGQPVLAGA
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL25_BURM7
Sequence: MKVVAFERQQQGTGASRRLRNAGKTTGIVYGGEAAPQMIELDHNALWHALKKEAFHSSILDLEVAGKSQRVLLRDVQYHPFRQLVLHVDFQRIDPKKKLHTKAPLHFLNAETSPAVKLSSAVVSHVVTEIEIECLPADLPEFLEVDLSKIEAGQSLHAKDIALPNGVALTAHVDAENPVIASATIPAGAVSDEAAAGEGETPAA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: LY65C_MOUSE
Sequence: MLFMAGPAASWSLRPLGLHGVPQALCAVLLTVLVMKTLVLGDTKLEDLHPQSLPLNKYLNCYRCLLETEELGCLLGSDTCLTPLGSSCVTLHIKNSSGFNVMVSDCYSKEQMVHCSYTRASPVFGFWIFYQCCFLDFCNNPDNRKNSMH
What is the function of this protein?
May have a role in hematopoietic cell differentiation.
What are the official names of this protein?
Lymphocyte antigen 6 complex locus protein G5c.
What are the subcellular locations of this protein?
Secreted.
Protein: KURT2_PARGR
Sequence: KIDGYPVDYWNCKRICWYNNKYCNDLCKGLKADSGYCWGWTLSCYCQGLPDNARIKRSGRCRA
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin inhibits cardiac sodium channels and voltage-gated T-type calcium channels (Cav3. 3/CACNA1I) (By similarity).
What are the official names of this protein?
Toxin PgKL2, Kurtoxin-like 2, Kurtoxin-like II, KLII.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AKT61_ALTAL
Sequence: MTFSTTKSVAMSPDDDAPSFDINSSRRLMSHSEVESRGNGYEVLQQAGTVRILLSRPERGNALSLSLAKDLTQLFQTFSSQHSVHRIVLTGKGKYFCSGMDLGEELYEDATERCLALQDLFGAIDACPKTTVAAINGPAFGGGVGLAFVCDIRVAVSTSFFCLSEVKLGLCPATVSRFIIREWGVSLARMAMLTARKIHPQALQEMGVLHAVALDEEALKVVTENLLDDLGFAAPQASAWCKALTRKTRNGNSDHDQFARQISETMVAPGSESEYGVAQFRRGRKNIRWEQAECLHTR
What is the function of this protein?
Enoyl-CoA hydratase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (PubMed:24611558).  AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).  On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase AKT1, the hydrolase AKT2 and enoyl-CoA hydratase AKT3 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:10432635, PubMed:10975654, PubMed:22846083).  Part of the EDA biosynthesis occurs in the peroxisome since these 3 enzymes are localized in peroxisomes (PubMed:20348386).  The exact roles of the 3 enzymes, as well as of additional AK-toxin clusters enzymes, including AKT4, AKT6 and AKTS1, have still to be elucidated (PubMed:10432635, PubMed:10975654, PubMed:22846083).  The Cytochrome P450 monooxygenase AKT7 on the other side functions to limit production of EDA and AK-toxin, probably via the catalysis of a side reaction of EDA or its precursor (PubMed:24611558).
What are the official names of this protein?
Enoyl-CoA hydratase AKT6-1, AK-toxin biosynthesis protein 6-1.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: RAD5_CRYNJ
Sequence: MSAEASPETGRFRTKSSPELFFPATDSEGEEQNDVPLTIVHPTQSTSSKFSINIASSSRPQHGITTGDFEATSQTSAHDNVDDDFSIVGHNPASSHPQGTIVAPRRKRSLQQAHSHHSSSSSSPVPSAPVIRADFRKGFLGEFVCEGWSLSKGRGYCSPGTKIVIERPKSKSTDVGAPKPGRKDSGPVRLVNGKVVGGVKSKQMTLGSMMAKKVEPAKKVKATTDQIIRFRNERGFEIGRLSIHEAGFLAHLLDTGVIQLSGNVIDCPQNLTTGCTILLNIKVYLARKAFENFGKHKREEHFSFWKDQRETAMEEAMRLRKDSLRSLFERIGVKPIQSSALSKVTPIQGVLNRQKGPDLEGSRLRSSPSTSTAEEKGKGRAAMPAVDDDGEDSGDEAEKLDEKQMNEIDSIYRKAQQGDTRLDEMDPPSTFLYTLRPYQKQALTWMNAREKGDSSVRNESLHPLWEEYLFKKDQLPGEPIEISDDDEQPDSTRKFYWNPYSGELSLKFPTSQNLSRGGILADAMGMGKTCMMASLIHTNREEKPAGNLESQTRDGVEGEIDEEPASKRIKFKQVTLSNQWRAVPTAPKVESFPRATLVVCPVSLAAQWHDELRKMSQQGSINSYVWYGGDRVDIEALLAGDGKERVDVIVTSYGTLTSEYQKWLRTKDRPNYEGGSLYDHEFLRIVLDEAHNIRNRLAMVSKACYELKGQRRWALTGTPIVNRLEDLYSLLHFLRITPWGNYSFFRSFVTVPFLNQDHKALNVVQYILESCLLRREKTMRDKDGRLIVDLPPKTVEIKVLQFSRAERQIYKFLEERAKKRFIDLDADGRAMSNYTSILAMLMKLRQCVDHPLLVLGKSGEDGELGEKILESGAGNGEGNLRDMIAMYAGGIRAETPEDVDKAYAAKVLKELGEQEDTPICELCSNEMFDEVLLPCYHRSCQDCIVEWIGTCEDQNKIASCPSCGKGPIKLADLRSVQRRHKRVNPITDAYPGGRDPNLKSSNDTTVTLGKVDLVTSTKLRALLRQLEEIRQEDPKAKALVFSQFTSFLDLIEATLTKQGIRWLRFDGTMSQAQRANTIEEFGRKTNEPLILLISLKAGGVGLNLTMANYVFLMDTWWNEAIEQQAIDRVHRLGQNKPVYVTRYIIKGTVEKRIMKIQRSKTALVNASLSNGAKTKETTLADIKKIFGMDEEDSEGEVY
What is the function of this protein?
Probable helicase, member of the UBC2/RAD6 epistasis group.  Functions with DNA repair protein RAD18 in error-free postreplication DNA repair.  Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats.  Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
What are the official names of this protein?
DNA repair protein RAD5.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PDXY_SHISS
Sequence: MMKNILAIQSHVVYGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIAAIDKLHTCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRHGLPASDIIAPNLVELEILCEHAVNNVEEAVLAARELIAQGPQIVLVKHLARAGYSRDRFEMLLVTADEAWHISRPLVDFGMRQPVGVGDVTSGLLLVKLLQGATLQEVLEHVTAAVYEIMVTTKAMQEYELQVVAAQDRIAKPEHYFSATKL
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: URK_BACMK
Sequence: MGTNKPVVIGIAGGSGSGKTSVTKAIFDHFKGHSILILEQDYYYKDQSHLPMEERLKTNYDHPLAFDNDLLIDHLQQLLAYEQVEKPIYDYTLHTRSEKIIPVEPKDVIILEGILILEDPRLCELMDIKVFVDTDADLRILRRMQRDIEERGRTMDSVIDQYVNVVRPMHNQFIEPSKKFADIIIPEGGQNHVAIDIMVTKIATILEQKVNL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA2_SALTY
Sequence: MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGGAGL
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA 2, Heme exporter protein A 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YKJA_BACSU
Sequence: MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFAIGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDIDERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNMEAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARGDISLDLNTANEPQHDPYLYKPGNNN
What are the official names of this protein?
UPF0702 transmembrane protein YkjA, ORF3.
What is the protein family that this protein belongs to?
Belongs to the UPF0702 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGA_YERPG
Sequence: MQKFDTKTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRAIGPEPIAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVIIKPSPDNIQELYLGSLKELGLDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLIWCDGPLGTTTYGDIYHQNEVEQSTYNFEYADVDFLFSCFEQYEKEAQSLLALETPLPLPAYERILKAGHTFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCKKNQN
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T1SH_HAEIN
Sequence: MSDWKEYSLGDISRNISRRFDFNAYPNVVFINTGDVLNNKFLHCEISNVKDLPGQAKKAIKKGDILYSEIRPGNGRYLFVDNDLDNYVVSTKFMVIEPNANIVLPEFLFLLLISNETTEYFKMIAESRSGTFPQITFDSVSSLSLNIPDKETQQKILDIITPLDDKIELNTQINQTLEQIAQALFKSWFVDFDPVRAKAQALSDGMSLEQAELAAMQAISGKTPEELTALSQTQPDRYAELAETAKAFPCEMVEVDGVEVDGVEVPRGWEMKALSDLGQIICGKTPSKSNKEFYGDDVPFIKIPDMHNQVFITQTTDNLSVVGANYQSKKYIPAKSICVSCIATVGLVSMTSKPSHTNQQINSIIPDDEQSCEFLYLSLKQPSMTKYLKDLASGGTATLNLNTSTFSKIEIITPSKEIIYIFQKKVVSIFEKTLSNSIENKRLTEIRDLLLPRLLNGEI
What is the function of this protein?
The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity.  The M and S subunits together form a methyltransferase (MTase) that methylates adenosines in the sequence 5'-RAACN(5)TAG-3'.  Methylation protects against cleavage by HindI (PubMed:4591672) (Probable).  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated (Probable) (PubMed:12654995).  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage (By similarity).
What are the official names of this protein?
Type I restriction enzyme HindI specificity subunit, S protein, Type I specificity subunit S.HindI, S.HindI, Type-1 restriction enzyme HindVIIP specificity subunit.
What is the protein family that this protein belongs to?
Belongs to the type-I restriction system S methylase family.
Protein: NDOR_PSEPU
Sequence: MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
What is the function of this protein?
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene (PubMed:2294092, PubMed:7037744, PubMed:10692370).  Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) (PubMed:2294092).  NADPH is also effective but yields only 39% of the activity obtained with NADH (PubMed:2294092, PubMed:7037744).  Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene (PubMed:10692370).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase system ferredoxin--NAD(P)(+), reductase component, Ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific).
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase component family.