PharMolix/UniProtQA huggingface dataset:
Protein: RS6_XYLFM
Sequence: MGRHYEIVLLVHPDQSEQVQAMLERYKALIENGHGKIHRLEDWGRRQLAYPIQKLVKAHYLMMNIEVEQSVLNELVDLFRFNDAILRHLAIKRSGPYTEQSFIMKSKDDKGDKPERRRRDDDESGDVGVSNDSDNDGGNAEAA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: Y2152_YERPE
Sequence: MGYFIDRRLNGKNKSMVNRQRFLRRYKSQIKQSIADAINKRSVTDIESGESVSIPIDDINEPMFHQGNGGLRHRVHPGNDHFITNDRVDRPQGGGGGGSGQGNAGKDGEGEDEFVFQISKDEYLDLLFEDLALPNLKRNQYKQLAEFKTHRAGYTSNGVPANISVVRSLQNSLARRTAMTASKRRELRELEAALTVLENSEPAQLLEEERLRKAITELKQKIARVPFIDTFDLRYKNYERRPEPSSQAVMFCLMDVSGSMDQATKDMAKRFYILLYLFLSRTYKNVDVVYIRHHTQAKEVDEQEFFYSQETGGTIVSSALKLMDEVVQERYNPAQWNIYAAQASDGDNWADDSPLCHELLAKKILPVVRYYSYIEITRRAHQTLWREYEDLEEKFDNFAIQHIREPEDIYPVFRELFHKQTVDN
What are the official names of this protein?
UPF0229 protein YPO2152/y2169/YP_1953.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: NUOK_NITSB
Sequence: MITLTHYLILSAILFSIALVGILRRKNLLMLFFATEIALNAVNIALAAFSKYYGDLTGQLFAFFIIAIAASEVAVGLGLLIIWYKRRGTIDLDSLQSMNG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEG2_CONMY
Sequence: MSDRAEVRNIPFKLGMYLTVGGVVNSNATRFSINVGESTDSIAMHMDHRFSYGADQNVLVLNSLVHNVGWQQEERSKKFPFTKGDHFQTTITFDTHTFYIQLSNGETVEFPNRNKDAAFNLIYLAGDARLTFVRLE
What is the function of this protein?
This protein binds beta-galactoside.  Its physiological function is not yet known.
What are the official names of this protein?
Congerin-2, Beta-galactoside-binding lectin 2, Congerin II.
Protein: APT_PROMA
Sequence: MIGSKLKEAIRSYSDFPKKGILFHDISPIFCKPDLYQELIEEMAKSEILNSSDAIISIDARGFLFGSCISLKLSKPLILARKAGKLPGPILSSTYNLEYGENSLSIQKESLNEFKNFAIIDDVLATGGTINCVKSLLTSHNKNISGACVVIELLALKAREKLDFPIYSTLTL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_PSEA8
Sequence: MQQLLNEILDEVRPLIGRGKVADYIPALAGVEPNQLGIAVYSRDGELFHAGDALRPFSIQSISKVFSLVQAIQHSGEDIWQRLGHEPSGQPFNSLVQLEFERGKPRNPFINAGALVICDINQSRFAAPAQSMRDFVRRLCGNPEVVSDSVVARSEYQHRSRNAAAAYLMKSFGNFHNDVEAVLLSYFHHCALRMSCVDLARAFCFLADKGFCKHSGEQVLNERQTKQVNAIMATSGLYDEAGNFAYRVGLPGKSGVGGGIIAVVPGRFTVCVWSPELNAAGNSLAGIAALEKLSERIGWSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: PKG2_ADE02
Sequence: MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPNRRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQDCGGNISFARRFLLYHHGVAFPRNILHYYRHLYSPYCTGGSGSGSNSSGHTEAKATG
What is the function of this protein?
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP).  Binds, along with packaging proteins 1 and 3, to the specific packaging sequence on the left end of viral genomic DNA and plays an active role in packaging of the viral genome into preformed capsids.  Specifically binds to the 5'-TTTG-3' nucleotides of the repeats making up the packaging sequence.  Forms a transcription factor called DEF-A through cooperative binding with packaging protein 1 (Probable).  DEF-A binds to downstream elements of the major late promoter (MLP) and stimulates transcription from the MLP after initiation of viral DNA replication.  Simultaneously suppresses early gene expression and is thus likely to participate in the early-late switch in the expression pattern of the late viral proteins.  May as well enhance transcription from IVa2 and pIX promoters.
What are the official names of this protein?
Packaging protein 2, Packaging protein 22K, L4-22K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae splicing factor family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MDS_PITHY
Sequence: MDFLKKSLFLVLFLGFFSLSICEEEKRETEEKENEQEDDREERREEKRLLGMIPVAISAISALSKLG
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive bacteria (S. aureus, MIC=32 mg/L) and fungi (C. albicans, MIC=128 mg/L) (PubMed:23415652).  Shows weak hemolytic activity (PubMed:23415652).
What are the official names of this protein?
Medusin-H1, MDS-H1, Medusin-PH, Phyllin-PH.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Medusin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UNG_IDILO
Sequence: MPWSTLLAEEKQKPYFQQLWQRVEQARQETVVYPPKEDVFNALKLTDPENIKVVILGQDPYHGPGQAHGLSFSVPEGVKFPPSLRNMFKAIAIDYPDTVLPQHGDLTSWAEQGVLLLNTVLTVEQGNAHSHASWGWETFTDTVISKVSDATDHVVFLLWGSHAQKKIPLIDGNKHCILTAPHPSPLSAHRGFFDANHFRKTNDYLQQHGRQPIRWV
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_CHLAB
Sequence: MKRRSVCVGDTVYVLAGNDKGKQGKVLSCLREKNKVVVEGVNVRTKNIKRSQENPKGKRINIEAPIHISNVRLSIDGAPAKLSVKVTENGRELWNKSSDGTSKLYRSVKERKG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ARC_STRCO
Sequence: MAAHDDDMNRGIRPGRGSEDPAGQVAYLEQEIAVLRRKLAESPRHTRILEERIVELQTNLAGVSAQNERLAGTLREARDQIVALKEEVDRLAQPPAGFGVFLQANEDGTADIFTGGRKLRVNVSPSVELDELRRGQEVMLNEALNVVEAMEYESVGDIVTLKEILEDGERALVLGHTDEERVVRLAEPLRGLTIRPGDALLLEPRSGYVYEVVPKSEVEELVLEEVPDIGYEQIGGLGGQIEMIRDAVELPYLYPDLFREHELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKVAEVTGQAAGKSFFLNIKGPELLNKYVGETERQIRLVFQRAREKASEGTPVIVFFDEMESLFRTRGSGVSSDVENTIVPQLLAEIDGVEGLQNVVVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFGKYLTERLPLHSDDLAEHEKDKSATVSSMIQTAVEQMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIENIVGRAKKMAIKDFLDKNQKGLRVSHLLQACVDEFKENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKQGADTGRSIDTVANTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: YAAA_SHIB3
Sequence: MLILISPAKTLDYQSPLTTTRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPANARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEASSSNGELVFKRYEQR
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PCRB_LYSSC
Sequence: MDYLEWRHVFRLDPAKDISDEDLEKICESGTDVILVGGTDNVTLDGVLDLLVRVRRFEVPIALEISTIDAITPGYDYYFIPTVLNSDDPKWIKNLHHAAIKEFGDIMVWDELVAEGYCILNPDCKVAHVTGATTDLSIDDIVAYARMAENFFKLPVFYLEYSGIYGNPEVVSAVKNELKHTKLFYGGGITSAKQAEEMAQYADTVVVGNIIYEDLKAALATVKAVKNTL
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family.
Protein: QSEC_HAEIN
Sequence: MKNRSLTLRLISVLCLTALFVWLGSTLVAWWQVRHDVNKVFDAQQVLFAERLANSDLSTILLESSTTLNKNSQSVLKKSYDDDALAFAIFSKTGKLLFSDGRNGKDFIFNYKTGFYNANIYDDDDKWRIFWRMAANGELVIAVGQELDYREDLIEEMILGQMWIWFASLPILIIVLGWLIHKELRPIKRLSQEVQTRKSGDVSLLNTEGLPVEILPLVKNLNQFFDRTSAMLQRERRFTSDAAHELRSPLAALRIQIEVAQLAGDDVALREQALLHLTQGIDRASQLIEQLLTLSRLDNLQALETLQLLDWEAIVQSLISERYFVAEKRKITLVFEKESEPKQKQGQSILVSLMLRNLLDNAIKYCPEDTIVSVKISSSQIIIEDNGGGVEPEDLKKLGQRFYRPAGQNEKGSGLGLSIVMRIAELHGFKVRLENVVKEGRRIGLKAIISL
What is the function of this protein?
Member of a two-component regulatory system QseB/QseC.  May activate QseB by phosphorylation (By similarity).
What are the official names of this protein?
Sensor protein QseC.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPX_DESVH
Sequence: MSSNTGGSDRELRCSFCAKGQDEVKRLIAGPGVYICDECVALCNEIVAHEDAGEREEMDRLLTPAEIKARLDEYVIGQHQAKKILSVAVHNHYKRVFYAEALGGEVELEKSNILLIGPSGSGKTLLAKTLARVLKVPFAIADATTLTEAGYVGEDVENILVQLLQNADYDIEAAAKGIIYIDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRMDTSNILFILGGAFIGLDKIVDQRSGGGSMGFGAKVSNRKDRPLGELLDQVHPNDLVKFGLIPEFIGRIPVVTHVDELGEEDLIRILTEPKNALVRQYQKLFELDKVTLRFTANALKSIASQAIERKTGARGLRNVMENVMLDIMYSLPTLEGVKECIINRAVVEKGREPVLIYDTEAKTGS
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SYA_MYCMM
Sequence: MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQRTPPYATATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIELAWALLTNSVADGGYGLDPEKLWATVYLDDDEAAGLWREVAGLPADRIQRRGMADNYWSMGIPGPCGPSSEIYYDRGPDYGPEGGPVVNEDRYLEIWNLVFMQNERGEGTTKEDYEILGPLPRKNIDTGMGVERVALILQGVPNVYETDLLRPIIDLVAARAPRGYDQGNHADDVRYRIIADHSRTAAILIADGVSPGNDGRGYVLRRLLRRVIRSAKLLNIDTAIVGDLMATVRDAMGPSYPELASDFDRINRIAVAEETAFNRTLASGSRLFDEVAGTTRSSGVSVVSGSDAFTLHDTYGFPIELTLEMASEAGLTVDEGGFRELMAQQRRRAKADAAARKHAHADLTAYRELVDAGPTEFTGFDELTSEARILGIFVDGKRVPVVAHGQAVDADRVELVLDRTPLYAESGGQIADVGTISGTGSGSSARAAVTDVQKIAKTLWLHRVNVESGEFVEGDGVVAAADAGWRKGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPLTEEQRGQIEEVTNQAVQADFAVHTFTEQLEKAKAMGAMALFGESYPDEVRVVEIGGPFSIELCGGTHVATSAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARVASLVERLKAAEKELERARLASVRAAAVNAAAGAERIGNVWLVAQRMSSEMTPADLRTLVGDIRGKLGSDPAVVALIAAPAGGESSTVPYVVAANRAAQGLGLGANELIKHLATAVDGRGGGKADLAQGSGKKPAGIDAALEALRAEIARVG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_RHILO
Sequence: MQEFLIPAKPDLQAARESWLKMLARERRLSPETVEAYERDTRQFLHFLTGHCGGSPGISDIANLRPADLRGFLAARRNAGAGARTLGRGLAGIRSLLRFLERRGLVNAAGAAALRAPRQPKSLPKPLTASDAKQVVSVEGQLAEEPWIAARNAAVLTLLYGSGLRISEALGLAGADLASETDTVLRVTGKGGKTRLVPVLPVALRAIAEYRRLCPYHLDPKGLLFRGARGGPLNPAIIQRDMAKLRSALNLPDTATPHALRHSFATHLLGRGGDLRTIQELLGHASLSTTQIYTGVDTARLLEIYESAHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_ENT38
Sequence: MPSLSKEAALVHEALVARGLETPLRPPVNELDNETRKRLIAGHMTEIMQLLNLDLSDDSLMETPQRIAKMYVDEIFSGLDYANFPKITVIENKMNVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDTVIGLSKINRIVQFFAQRPQVQERLTQQILTALQTLLGTNNVAVSIDAVHYCVKARGVRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: ENV_HV1W1
Sequence: MRVKGIRRNCQHLWIWGTMLFGMWMICSAVEQLWVTVYYGVPVWKEATTTLFCASDAKAYSTEAHKVWATHACVPTNPNPQEVVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCIDKNITDWENKTIIGGGEVKNCSFNITTSIRDKVHKEYALFYKLDVVPIKSNNDSSTYTRYRLIHCNTSVITQACSKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENFTDNAKTIIVHLNESVEINCTRPNNNVRRRHIHIGPGRAFYTGEIRGNIRQAHCNISRAKWNNTLKQIVEKLREQFKNKTIVFNHSSGGDPEIVTHSFNCGGEFFYCDSTQLFNSTWNVTGISTEGNNNTEENGDTITLPCRIKQIINMWQGVGKAMYAPPIGGQIRCSSNITGLLLTRDGGNSSSREEIFRPGGGNMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGAIGAMFLGFLGAAGSTMGAASLTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNASWSNKSMDQIWNNMTWMEWEREIDNYTSLIYNLIEESQNQQEKNEQELLELDKWASLWNWFSITNWLWYIKIFIMIVGGLVGLRIVFSVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGTEEEGGERDRDRSVRLVHGFLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSKELKNSAVGLLNAIAIAVAEGTDRVIEVVQRICRAIIHIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: HEM1_DICNV
Sequence: MHNTIYVLGFRHQTTPASVREKLAFSPENILNTLPFLQAQCAGAEILLLSTCNRSEWYFASNTPPRLEEWLYQHTAISSEELKRHLFIYTDREAVQHLYRVACGLDSLILGEPQILGQLKAAYRLAKKAGSIGSWLERLFQHSFALAKHVRHQTDIGKNPVSVAYAGVQLTHQFFDDYSKRTAIIVGAGETAQLVARYLHDLKIKRLIIANRTLNRAQQLAESVGGYALSLPQLADHLHEADMIFGCARADVFLVTQNMAITALQRRQNTLQVYIDLGIPHNFDRNIDNKENAFLYDMDNLAQLIDKNRETRQKAAAEAETFIRLYSNDFLNWTQEKPQQHMIRHIRADAHNIRQKLLIMAYRQLAQGADPEKVLAEMSYKLTNKLLHQPCALIHAIPPDHKDWLAVVADTFNAELPK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: URE2_CUPPJ
Sequence: MIPGELMAADGEIELNAGRHTASVTVANTGDRPIQVGSHFHFYETNAALSFDREATRGFRLNIAAGTAVRFEPGQTRTVELVALDGDRIVYGFNGKIMGAL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STML1_MOUSE
Sequence: MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGSVGPGADAPESWPSCLCHGLVSVLGFLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRNPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNTATRMTAHNAMTKALLRRPLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSAVGRVPSPGPDTLEMINEVEPPASLAGAGAEPSPKQPVAEGLLTALQPFLSEALVSQVGACYQFNVILPSGTQSIYFLDLTTGQGRVGHGEPDGIPDVVVEMAEADLQALLSKELRPLGAYMSGRLKVKGDLAVVMKLEAVLKALK
What is the function of this protein?
May play a role in cholesterol transfer to late endosomes (By similarity).  May play a role in modulating membrane acid-sensing ion channels.  Can specifically inhibit proton-gated current of ASIC1 isoform 1.  Can increase inactivation speed of ASIC3.  May be involved in regulation of proton sensing in dorsal root ganglions (PubMed:24247984).
What are the official names of this protein?
Stomatin-like protein 1, SLP-1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein. Cytoplasmic vesicle. Cell membrane; Single-pass type III membrane protein. Late endosome membrane. Membrane raft.
Protein: SSRP_LACDA
Sequence: MKQKAKDENVLAQNRQARHDYFIKDTYEAGIALTGTEIKSVRARHVTLRDGYVQIINGSAFLENVHIDEYKEGNRYNHDPLRSRRLLLHKKEIAKLADVKAQKGMTIVPLKVYLKHGFAKVLIGVAQGKKEYDKRETIKKRDQDRELRRKYRI
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TPIS_LATCH
Sequence: APRKFFVGGNWKMNGDKKSLGELIQTLNAAKVPFTGEIVCAPPEAYLDFARLKVDPKFGVAAQNCYKVSKGAFTGEISPAMIKDCGVTWVILGHSERRHVFGESDELIGQKVSHALSEGLGVVACIGEKLDEREAGITEGVVFEVTEVIADDVKDWSKVVLAYEPVWAIGTGKTASPQQSQELHGKLRKWLKENVSETVADSVRIIYGGSVTGATCKELASEPDVDGFLVGGASLKPEFVEYKDVRQ
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_BURMS
Sequence: MTAIQQFFKTFFLTELLKGLALTGRYTFKRKFTVQFPEEKTPISPRFRGLHALRRYENGEERCIACKLCEAVCPALAITIESETRADNTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQILEYHGEKRGDLYFTKDMLLAVGDRYEKEIAAAKAADARYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CDPAS_SULAC
Sequence: MIGLLLGLIYYIPALVANGSAPFIKSGTPIDFKRKLNDGRRVLGDGKTFEGLLLSLTFGTTVGAIISRFLGIEWIIIGFVESLGAMLGDMLGAFIKRRIGLERGARAPILDQLDFILGATVVLISFNVNLNIYQVVFVCVLVIALHMFTNYVAYRLKIKSVPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.