PharMolix/UniProtQA huggingface dataset:
Protein: T23O_TRICA
Sequence: MSCPLRPSEAQEGDQLSEECGMLYGEYLMLDKILEAQRLLSEQNNQPVHDEHLFIVTHQAYELWFKQIIYELDSIRNIFSDVLEESQTLEILKRLNRVVLILKVLVDQVMILETMTPLDFMDFRCYLRPASGFQSLQFRLLENKLGVRQENRVKYNQNYSKVFGNDEKALEQIAKSEKEPSLTDLVQRWLERTPGLELEGFNFWGKYQKAVEKLLTEQKELAEKEEAETLKRYKLNDLEKRREVYESIFKVEVHEALMSRGERRFSHKALQGAIMITFYRDEPRFSQPHQILTLLMDIDSLITKWRYNHVLMVQRMIGSSQLGTGGSSGYQYLRSTLSDRYKVFVDLFNLSTFLIPRSYIPPLSTSMRSHLCNWGSANSTNIVSNGNN
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety (By similarity).  Required for normal eye pigmentation.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: REPA_MSVN
Sequence: MASSSSNRQFSHRNANTFLTYPKCPENPEIACQMIWELVVRWIPKYILCAREAHKDGSLHLHALLQTEKPVRISDSRFFDINGFHPNIQSAKSVNRVRDYILKEPLAVFERGTFIPRKSPFLGKSDSEVKEKKPSKDEIMRDIISHATSKEEYLSMIQKELPFDWSTKLQYFEYSANKLFPEIQEEFTNPHPPSSPDLLCNESINDWLQPNIFQVSPEAYMLLQPTCYTLEDAISDLQWMDSVSSHQMKDQESRASTSSAQQEPENLLGPEA
What is the function of this protein?
Implicated in enhancement of V-sense gene expression.  Acts a an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein A, RepA.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: CD59_SAISC
Sequence: MGIQGGSVLFGLLLVLAVFCHSGNSLQCYSCPLPTMESMECTASTNCTSNLDSCLIAKAGSGVYYRCWKFDDCSFKRISNQLSETQLKYHCCKKNLCNVKEVLENGGTTLSKKTILLLVTPFLAAAWSRHP
What is the function of this protein?
Potent inhibitor of the complement membrane attack complex (MAC) action.  Acts at or after the C5b-8 stage of MAC assembly.
What are the official names of this protein?
CD59 glycoprotein, MAC-inhibitory protein, MAC-IP, Membrane attack complex inhibition factor, MACIF, Protectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: HOG1_ASPFU
Sequence: MAEFVRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSARDQLTGQPVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVKSLPKRERQPLANKFKNADPEAVDLLERMLVFDPKKRIRAGEALAHEYLSPYHDPTDEPEAEEKFDWSFNDADLPVDTWKIMMYSEILDFHNIDQGNDAGQVLMEGGVAQAQQNYA
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase hog1, MAP kinase hog1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYH_KLEP3
Sequence: MAKNIQAIRGMNDYLPGETALWQRIEGSLKQVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYVGPMFRHERPQKGRYRQFHQIGAEVFGLQGPDIDAELIMLTARWWRELGISDHVSLELNSIGSLEARANYRDALVAYLEQFTDKLDEDSKRRMYTNPLRVLDSKNPDVQALLNDAPALGDYLDEESKAHFAGLCALLDDAGIRYTVNQRLVRGLDYYNRTVFEWVTTSLGSQGTVCAGGRYDGLVEQLGGRATPGVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGTDTQSAAMRLAEQVRDALPGVKLMTNHGGGNFKKQFARADKWGARIALVVGESEIADGNVVVKDLRSGEQTTVTQESVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_COLP3
Sequence: MEAIYNPQAIEATVQKFWTDNNTFQAIENPDKEKFYCLAMFPYPSGRLHMGHVRNYSLGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIKNKTAPGKWTYENIDYMRNQLQSLGFGYDWGRELATCKPDYYRWEQWFFTQLFEKGLVYKKNATVNWDPVDQTVLANEQVIDGRGWRSGALVERKQIPQWFIKITDYAEELLDDLDQLTEWPEQVKTMQRNWIGRSQGVEMTFAVADSTESFDIYTTRPDTLMGVTYVALAAQHPLAVAAAVDNADLAAFIDECKNSKTTEADMAAMEKKGVDTGLKAIHPLTGKLVPVWAANFVLMDYGSGAVMSVPGHDQRDYEFALKYGLAIEQVIAGQEADDINKAAITEKSTLINSGEFDGLDFEEAFKAISDKLISENKGKTTTNYRLRDWGVSRQRYWGTPIPMINLANGESVPVPTNELPVVLPEDVVMNGTTSPIKADPEWAKTLYNGEEALRETDTFDTFMESSWYYARYCSPNDDTQMIDPAKANYWLPVDQYIGGIEHAILHLLYSRFFHKLLRDVGLVKCDEPFKKLLCQGMVLAETYYREADNGAQEWIAPTDVEVERDEKGQITSSISKIDGQPVLSAGMSKMSKSKNNGIDPQEVIEKYGADTVRLFIMFTSPPEQTLEWSDAGVEGAHRFVKRVYKLAHEFVESTNNSAVVDIAELTLNADHKKLRRELHKTIAKVTDDIGRRNTFNTAIAAIMELMNHLGKAKVNSDEDKAVMQEAVRAVVLMLTPITPHLCHHLWQLVGGSDENVEDASWPVVDNSALVEDEKLIIVQVNGKVRAKITVAADASKEDVEALGLNDESVLKFTDGNTIRKVIYIPGKLLNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2B1_HERAU
Sequence: MAINPITRNKIKDYLNSFIQQQLSVYSQRSLREFQDVDSYPSSLSKDGDLKPFHASLIPASIMRLNRFERSLSTGLGSTFEECTRLIALDHHAVALRNYDIQAALDQAQWAAIDQLISTIDRGLKHQTPSLNQMLEQIQSIPLTGILETHIVRADLYIQRHDGSELFFEIKSPKPSKGQCLEVMQRLLRIYTIKQQSAVPVKAFYAMAYNPWGISRASYRSSITKKYTDFSNAVVIGQEFWSLIGEPSTYTELLEIYHEVGLAKSAEITQKLLQ
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGWCC-3' and cleaves after G-1 (PubMed:7607523, PubMed:12654995).  This system is less active than isoschizomeric RM. HgiEI (PubMed:7607523).
What are the official names of this protein?
Type II restriction enzyme HgiBI, R.HgiBI, Endonuclease HgiBI, Type-2 restriction enzyme HgiBI.
What is the protein family that this protein belongs to?
Belongs to the TdeIII type II restriction endonuclease family.
Protein: HISXH_SYNY3
Sequence: MLRLITQSGDIVQELRRLHHRPVPSPWPVMAQVVAAMEHWAAMDQDAPPRVSGAELDAAYQRISQEKLSVIRQACAALEQVYRPQLPKTQVSFPEDGTVRGQRFYPVRRAGFYLEAKRGDALGNLLRQGMLAKTVGVAERVLVTETISSTILVAAQEMGIEEIYLAAGVPAIAMLTWGAKNIAPVESITGAGCPRVMAAKQLVSGVVTIDQTLARTNLMVLADGEANGQWLALDLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKALAHYGLVAIVEDLEACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHYLSGANRLQTQDGAMATASELAFHCFLRSSQLLDYGNNPPPPWLKDLVNWQGLTAIEERLGQLGRLKES
What are the official names of this protein?
Histidinol dehydrogenase homolog.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: Y1075_MYCLB
Sequence: MYGTGNNAVTPDQAAASRADSLFAHAEGSISEDAILASARERSEEIGARAVTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGMSYDGVLTTIDIEPEYLRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLADESYDLVFIDADPIDQPAYVVEGVRLLRSCGIIVVHRAALGGRAGDPAARDAEVTAVREAARLIAENERLTPALVPLGDGLLAAVRE
What are the official names of this protein?
Putative O-methyltransferase MLBr01075.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
Protein: MGN2_MOUSE
Sequence: MGSDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.
What are the official names of this protein?
Protein mago nashi homolog 2.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BTRM_NIACI
Sequence: MGGMQVQITNLTEWLADQGVRQDVLTTGIPGIPRTLQLRDRLTVHSVRFMTLPFKSSQTGTVFLDQSWFMGAVKWIVLNGKKNNYDAIHVHASGVVWPLLAGMFAQKYLKKPLILTIHCSRIFTYKPMNKWDQFVHDFVKSVELKSIKLSHKAVVLTDKRLDSYNRLLEDSSKMTAISDCIGSNHLSHSIDCPFCSRLKTELLGKKTVLFLGRIAHEKGWSTFVSVAKELADKIGDLQFIVCGDGPQREAMEEQIKAANLQNQFRITGFISHKFVSCYLHHAQLFLLPSHHEEFGGSLIEAAIAGVPIISTNNGGPADIFTHGETAILKDPGDVSGIADEAYKILTNDSVAESLRLHSRPEVVSKFLPHCVYPNYLNLYSSKEAAVHEG
What is the function of this protein?
Glycosyltransferase involved in the biosynthesis of butirosin by mediating conversion of 2-deoxystreptamine (2-DOS) to 2'-N-acetylparomamine using UDP-alpha-D-glucosamine as sugar donor.
What are the official names of this protein?
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, Butirosin biosynthesis protein M.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: T185B_BOVIN
Sequence: MNPRGLFQDFNPSKFLIYACLLLFSVLLPLRLDGVIQWSYWAVFAPIWLWKLLVLAGASVGAGVWARNPRYRTEGEACVEFKAMLIAVGIHLLLLMFEVLVCDRVERGTHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDRIIHWPWLVVFVPLWILMSFLCLVVLYYIVWSLLFLRSLDVVAEQRRTHVTMAICWITIVVPLLIFEVLLVHRLDGHNMFSYISIFVPLWLSLITLMATTFRRKGGNHWWFGIRRDFCQFLLEIFPFLREYGNISYDLHHEDSEDAEETSAPEAPKIAPMFGKKARVVITQSPGKYVPPPPKLNIDMPD
What are the official names of this protein?
Transmembrane protein 185B, Protein FAM11B.
What is the protein family that this protein belongs to?
Belongs to the TMEM185 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ECHD3_XENLA
Sequence: MSWLRSCGERTAPALRGTYRILAGQSRFVNSSSHLQHTPLTVLQQEHGIRRIILNNPQQRNALSLPMIQSLQKDILHEADDPNLRVIIISAEGNVFSSGHNLKELTAEYGKDYHMEVFNTCAKLMTLFQTLPVPVIAEVNGLATAAGCQLVASCDIAVASDKSRFATPGVNVGLFCSTPGVALGRAVPRKVALEMLFTGEPISAHDALLHGLVSKVVPEENLKSETNRIALKICQTSHSVVALGKSTFYRQMAKSLTDAYKLTSEVMVENLAMKDGQEGLKSFIQKRKPVWTHS
What is the function of this protein?
May play a role in fatty acid biosynthesis and insulin sensitivity.
What are the official names of this protein?
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYL_VIBCH
Sequence: MQEQYNPQDIEHKVQQHWDNNKTFVVSEDPNKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVSRFQRLQGKNVLQPIGWDAFGLPAENAAVKNNTAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCRPEYYRWEQEFFTKLFAKGLVYKKTSSVNWCPNDQTVLANEQVEDGCCWRCDTPVEQKEIPQWFIKITAYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELKFAVKGENTDLEVYTTRPDTLMGVTYVGIAAGHPLATKAAANNPALAAFIDECKNTKVAEAEIATMEKKGMATGLTAIHPLNGREVPIYIANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVIKPADGSELDVSEAAYTEKGVLFASGEFDGLDFQAAFNAIAAKLEAEGKGKKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGQVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNGEPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYSRFFHKLLRDAGYVKSDEPFKKLLCQGMVLADAFYYTNDKGGKEWVSPTEVKVERDGKGRIVSAVDATGRQVEHSGMIKMSKSKNNGIDPQEMVDKYGADTVRLFMMFASPADMTLEWQESGVEGANRFLRRVWKLVREHTELGQAPALDASALNADQKALRRDVHKTIAKVTDDVARRQTFNTAIAAIMELMNKLTKAPMTEAQDRAILDEALKAITLMLYPITPHICFEMWVALGQSNIDTASWPTYDEAALVEDEKLIVLQVNGKLRGKLTVAADATQQQVEALGMQDENVQKFIDGLTVRKVIYVPGKLLNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_ANADF
Sequence: MAIQQRDSRGGTNRDARTNRRIKAREVRAIGPEGEQLGVLPIEQALARAQELGMDLVEVSPMAKPPVCKIMDYGKFKYLEKKKQNEAKKKQVVVQLKEVKLRPRTEEHDYATKIKKVREFLGESNKARITVTFRGREMSHRELGQKVLQRIIEDLREVAVIEAAPRMEGRQMFMILAPNPRMLQAQRDRAKAAAQAAPAAAPQPGAPAAPPAAPAPAPAPEQTPEAGPR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG2_VIBVY
Sequence: MADLSKYRNIGIFAHVDAGKTTTTERILKLTGKIHRLGEVHDGASTMDFMDQEAERGITIQSAATTCFWKDHRFNVIDTPGHVDFTVEVYRSLKVLDGGIGVFCGSGGVEPQSETNWRYANESEVSRLIFVNKLDRMGADFFRVVEQVKKVLGANPLVMTLPIGREDEFVGVVDVLTRQAFVWDDSGLPENYEIKEIPADMVDQVEEYREMMIESAVEQDDELMMAYMEGEEPSIEQIKACIRKGTRDLAFFPTYCGSAFKNKGMQLVLDAVVDYLPSPTEVEPQPLTNPETGEPTGEVATVSVDAPLKALAFKIMDDRFGALTFIRIYSGRLKKGDTVLNSATGKTERIGRMVEMHANDRNELEAAQAGDIIAVVGMKNVQTGHTLCDPKHECTLEPMIFPEPVISIAVKPKDKNGSEKMGIAIGKMVAEDPSFQVETDEDSGETILKGMGELHLDIKVDILKRTYGVELEVGAPQVAYRETITKAVEDSYTHKKQSGGSGQFGKIDYRIKPGEPNSGFTFKSTVVGGNVPKEFWPAVEKGFEGMMQNGVLAGFPTLDVEVELFDGGFHAVDSSAIAFEIAAKGAFRQSMPKAGPQLLEPIMKVDVFTPEDHVGDVIGDLNRRRGMIKNQEMGATGVRVKADVPLSEMFGYIGTLRTMTSGRGQFSMEFSHYSACPSNVAEQVIAEVKERNAKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_BRASB
Sequence: MSRNYFGTDGIRGRANGLITPELALKVGQAAGLLFQRGEHRHRVVIGKDTRLSGYMIEYAMVAGFTSVGMDVLLVGPMPTPAVAMLTKSMRADLGVMISASHNLFEDNGIKLFGPQGFKLSDDVEKQIEQLLDESLDKKLAQSASLGRARRIDGVHDRYIEFAKRTLPRDLSLDGLRVVVDCANGAAYKVVPEALWELGADVISIGVEPDGFNINKECGSTSPEALCRKVREMRADIGIALDGDADRVILVDERGHIVDGDQLLAVIAQSWKEDGRLARPGIVATVMSNLGLERFLQGQGLELVRTPVGDRYVLERMLADGYNLGGEQSGHIILSDYATTGDGFVAALQVLATVQRLRRPVSEVCHKFDPLPQILKNVRYRSGKPLDADAVKSAIDTGQKRLNGHGRLLVRSSGTEPVIRVMGEGDDRDLVEEVVDDIVTAVGNAAAAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RL23_RICCK
Sequence: MSSYKYYDLIRKPIITEKTTALSEQNKYAFYVDKFAAKLTVKKAIEEIFKVKVKKVNILNVKGKNKRFKGIIGTQINRKKAIVTLEKDNNIDFAGGIK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: LEXA_STAHJ
Sequence: MRELTKRQSEIYDYIKHVVQTKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIKRDPTKPRAIEIVSEQTNDAVNMEETIYVPVIGKVTAGIPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGESMIEAGILDGDKVIVRSQTIAENGDIIVAMTEDDEATVKRFYKEKTRYRLQPENSTMSPIYLDNVTVIGKVIGLYREL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RF1_COXB2
Sequence: MKPSLIEKLKTLTYRYSEIGGLLSDSTVINDQDRYRELGKEYAQLEPIVKCFQQFQQNEKAIESAEEMQQEKDPELRKLAEEELEQLTLKKEELEDQLKLLLVPKDPNDELNVFLEIRAGTGGNEAAIFAGDLFRMYARYAETKGWRVNIVSAHEGEHGGFKEVIARVIGEGVYSQLKFESGAHRVQRVPVTESQGRIHTSACTVAIMPEVDEIDQIKINPAELRIDTFRASGAGGQHVNRTDSAIRITHLPTGVVVECQDERSQHKNKARAMSLLQSKLLAAERAKQDQEQAAKRKSLVGSGDRSERIRTYNFPQGRVTDHRINLTLYQLDEVIEGDLDPVIGPLIRELQAEQLAELSGE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_NITOC
Sequence: MACPNWRVRLAARIIRGGGVIAYPTEGVFGLGCDPGRKAAIERILQLKGRSISKGFILIAADFVQLQSYLLPLTASTRSRLEVTWPGPVTWLLPARGDVPPWLRGRYDTLAVRVTAHPLAACLCRTLGHALVSTSANRAGRPPAQTTLQVRRSFGSSLDYILPGITGKRAGPSEIRDGRTGQRLR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP1_ROTPG
Sequence: MATFKDACYYYKRLNKLNHAVLKLGVNDAWRPSPPTKYKGWCLDCCQHTDLTYCRGCSIYHVCQWCNQYGRCFLDDEPHLLRMRTFKNNVTKEDLANLIDMYNVLFPVNQKTVNKFINNTKQHKCRNEYVPQWYNHLLMPITLQSLSIELDGDTYYIFGYYDNMKNINQTPFSFVNLIDMYDKLLLDDVNFNRMSFLPLILQQEYALRYFSKSRFISEEKRQINHSHFSINILENLHNPNFKIQITRNCSTMSVRWNEACKLVKDVGTYFDILKTSHVEFYDVSPRCRMFTQHKLKAVSKVIKPNYVTSNHRALATEVHNCRWCSVNNNLIVWNDFRLRNICDNILNFIRALIKSNTGIGHCSSQERIHIYIRDVFDVCDESKWNASVVGIFNCLEPVELGNAHYILLNHEVNWDVANVLIQNIGKIPQILTLNDVITALHSMIYDWFDVRYMRNTPTTTFTVDKLKQLCARRKTVDYDSGVSDVE
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.  Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: FKB1A_EMENI
Sequence: MGVEVQRISPGDGKNFPKPGDTVSIHYTGTLADGSKFDSSRDRPGTFVTQIGVGRVIKGWDEGVLQLSVGEKAKLICTPDYAYGARGFPPVIPPNATLTFEVELLKIN
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 1A, FKBP, FkbA, Peptidyl-prolyl cis-trans isomerase, PPIase, Rapamycin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHEG_COROI
Sequence: MDSPAFAVTGMFAAAKVGVTSFTGATEPVSTRRRTSGNVTMAVDAFQKKFQTFGKIGVDYSRPKKLASYKRGGFDAASVEYPNAPSFAGKYSIAPCGQPSGASKILMKYDEYCAKGVLQVFKRNAVPFGVYTTKCTEGTVAGQAQEKRVFNRTMAFRQAQKPVNVRLAEQYEARRKCFILANGCSREEDQFKSMPVSAATFLAGKHESLGTCFRVVTPSNIAEDYIASGVRMQLVAKSNSTGVYGVGSCMEGFAKGDAEARRVAALAAEYRALQQSPAAVTGRQYESSRMAVKLYAQNCSHEQEQLYKWPATAAAFCRY
What are the official names of this protein?
R-phycoerythrin gamma chain, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=Forms the periphery of the phycobilisome rod.
Protein: MNMG_POLNA
Sequence: MFYPQEFDVIVVGGGHAGTEAALAAARMGCKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDAMGGAMALATDEGGIQFRILNGSKGPAVRATRAQADRILYKAAIRRMIENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGIKFRARTVVLTAGTFLDGKIHVGLNNYPAGRAGDPPAVSLSARLKELKLPQGRLKTGTPPRIDGRSIDFSKCGVQPGDGMPGGTPGPVPVFSFMGGNVPHPKQVPCWITHTNERTHDIIRSGFDRSPMFTGKIDGVGPRYCPSVEDKINRFAGKDSHQIFLEPEGLTTHEIYPNGISTSLPFDIQYALVRSMAGMENAHILRPGYAIEYDYFDPRALKTNFETRAIGGLFFAGQINGTTGYEEAAAQGMFAGINAALQCQEKEAWLPKRDEAYLGVLVDDLITKGVTEPYRMFTSRAEFRLMLREDNADMRLTEKGRELGLVDDARWDAFNRKRDIVSRETQRLRALWINPNNLPASEAERVLGKAIEREYNLADLLRRPDVNYAGLMSLDGGRYANPEIPTGNEDVSRETSTDSALPADLVKSVIEQIEITAKYAGYIDLQKVEVERASHYENLKLPADLDYLQVSALSFEARQMLSKHRPETLGLASRIQGITPATISLLLVHLKKNLWKNTTPLKSAEAEA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METJ_SALSV
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGIDPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3E_RAT
Sequence: MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.  Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway.  May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e, Eukaryotic translation initiation factor 3 subunit 6, eIF-3 p48.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, PML body.