PharMolix/UniProtQA huggingface dataset:
Protein: BIP_PIG
Sequence: DEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYCLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKA
What is the function of this protein?
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity).  Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity).  Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR).  In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1.  Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity).  Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER).  May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel.  Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.  May also play a role in apoptosis and cell proliferation (By similarity).
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, GRP-78, Binding-immunoglobulin protein, BiP, Heat shock protein 70 family protein 5, HSP70 family protein 5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Cell surface. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localizes to the cell surface in epithelial cells; high levels of free iron promotes cell surface localization (By similarity).
Protein: ACYP_SYNPW
Sequence: MSRGKHKPTITTERWRFFVEGKVQGVGFRQGCCRRAMDLGLSGWVRNLPDGRVEVQAEGTPMALSELRLWCERGPADARVSQVRPSQLPITGADWFEIRS
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PEX21_KLULA
Sequence: MSVCQTNPLNTLVSKSGYRFGQPNQHQQSIAQQQSRPRNNALDHQFSQFTGASGPSFAHPQHQQLPMAAVVANATTAASTTSNTATASDHHVWIDQFANMQVHDKTEFPTDYKQMYSQYEARGASYSMGAPVMVSHSQMFPRHQQSLMVNQLESQAYASSSAKLDEQFAELERQVQDDEKEQQQDKDDDFHLKETSPLDEDQRQLKEAAQSIYTTLSDKSSTTSSKFSNSKFLGLMRNISDGVITLKKNPDEDKYTELYSPSTGETFGEEYFPVQDSVLGDPLDSIGDLSNMSSSEAAAKVYHNSV
What is the function of this protein?
Mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (By similarity).  Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity).  PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (By similarity).
What are the official names of this protein?
Peroxisomal protein PEX21, Peroxin-21.
What is the protein family that this protein belongs to?
Belongs to the peroxin-21 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS13_RALPJ
Sequence: MARIAGVNIPNHKHTVIGLTAIYGIGRSRAQKICEATGIPTDKKVKDLTDPDQDALRKEIEKFLVEGDLRRETTMNIKRLMDLGCYRGVRHRKGLPMRGQRTRTNARTRKGPRKAGVALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SIL1_XENLA
Sequence: MDLYCSFIRISNHVKMSTFILLTLCFYVALSDRSPEYALTKVTEAEDDGNVEAIVENEPDPEDQEIFYPTREWQVVKPGQAVPAGLHMRLNLQTGKNEAKLLEEKEGKDRPKQKRKSSTTSDKYTKKELKEALTKFKEGAEQLSPAEEKDYLQDIKQRFRPIEDLQKAFNDLNINVETDFEIMTKIVNRFNSSSSTTEKVSALYDLEYYVHQVDNAQNLLKLGALQLLINSLNSTDTLLIENSAFVIGSALSSNPKVQIEAFEAGALQKLLVILAADQEVSVKKKTLYALSSMLRQFPYAQQRFMKLGGLQILKNFFKEKNAESLYIRVITLLYDMIMEKMLLYKENNTEQYEQKYQQYNQINLLESITEQGWCPIISDLLRLPENDSREKVLKAVLTLIPLCRAEFLKDCNLLTLLNSLRKEYEGLAAEELRSGEQDGYFSEILSLTISITDKLK
What is the function of this protein?
Required for protein translocation and folding in the endoplasmic reticulum (ER).  Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
What are the official names of this protein?
Nucleotide exchange factor SIL1.
What is the protein family that this protein belongs to?
Belongs to the SIL1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: NU4LM_MUNGO
Sequence: MSLVYMNIMTAFMVSLAGLLMYRSHLMSSLLCLEGMMLSLFVLATLTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLSY_ECOHS
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TLP_BACC0
Sequence: MPNPDNRSDNAEKLQEMVQNTIDNFNEAKETAELSNEKDRSAIEAKNQRRLESIDSLKSEIKDES
What are the official names of this protein?
Small, acid-soluble spore protein Tlp.
What is the protein family that this protein belongs to?
Belongs to the Tlp family.
What are the subcellular locations of this protein?
Spore core.
Protein: HGD_BURM9
Sequence: MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: PSD_PARPJ
Sequence: MNYPHPIIAREGWPFIAIAAVVALLVHFIAGFGFSWLFWLLLIFVVQFFRDPARPIPTQANAVLCPADGRIVAVETAHDPYANREALKISVFMNVFNVHSQRSPVDGAISKVEYFPGAYLNAAVDKASTENERNAVVIEMAGGQTVTSVQIAGLIARRILCYVRAGEPLTRGQRYGFIRFGSRVDVYLPVGSRPRVSIGEKVSASSTILAEL
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VATD_CLOBL
Sequence: MKLNVNPTRMELTKLKKRLTTATRGHKLLKDKQDELMRRFIGMIKKNNELRKDVEKELEGSFKDFLMASAVMSPEFLEEAVAYPKESISVDVKKQNIMSVNVPVFDFKRKLEGDKGSIFPYGFANTSAELDGAIEKLYGILPKLLELAKVEKACQLMADEIEKTRRRVNALEYMTIPQLEETIRFIQMKLDENERSTVTRLMKIKSMMEEKQSNMV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: DNAJ_LEPBP
Sequence: MSDRGYYEVLGVSKGASDDEIKSAYRKLAIKYHPDKNKGDKEAEEKFKEATEAYEVLRDPQKRQAYDQFGKAGVNAGAGGGYGAGAYTDFSDIFGDFGDIFSEFFGGGGGGGSRGGGRRSGPQRGSDLRYNLEVSLEDAALGKEYKIEIPRLETCVDCTGSGASKGSSPTVCPDCSGTGQVRRTQGFFSVTTTCPRCKGKGKVISNPCKTCKGEGLTEKRRTIHIKIPAGVESGSRLKVSGEGESGPNGGPSGDLYVVTHIKKHPVFERQGNDLIVQKSISLSMACLGGEIEVPSIDGKTIQLKIPEGTESGQIFRLKGHGIPYLGSYGKGDQHVIIKVEIPKKLSKKQKELMEEFARESGEKVGSGGKSKLFFR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCX5_GUITH
Sequence: MLKDIQIYELNERIKKKKLKTYNRNKLLKLLTYVERHKICIVLYFNLIKRQLIYIEFVFIRN
What are the official names of this protein?
Uncharacterized 7.8 kDa protein, ORF62.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YFIR_BACSU
Sequence: MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGFSRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDVADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATIAKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YfiR.
Protein: CITN_KLEPN
Sequence: MTNMSQPPATEKKGVSDLLGFKIFGMPLPLYAFALITLLLSHFYNALPTDIVGGFAIMFIIGAIFGEIGKRLPIFNKYIGGAPVMIFLVAAYFVYAGIFTQKEIDAISNVMDKSNFLNLFIAVLITGAILSVNRRLLLKSLLGYIPTILMGIVGASIFGIAIGLVFGIPVDRIMMLYVLPIMGGGNGAGAVPLSEIYHSVTGRSREEYYSTAIAILTIANIFAIVFAAVLDIIGKKHTWLSGEGELVRKASFKVEEDEKTGQITHRETAVGLVLSTTCFLLAYVVAKKILPSIGGVAIHYFAWMVLIVAALNASGLCSPEIKAGAKRLSDFFSKQLLWVLMVGVGVCYTDLQEIINAITFANVVIAAIIVIGAVLGAAIGGWLMGFFPIESAITAGLCMANRGGSGDLEVLSACNRMNLISYAQISSRLGGGIVLVIASIVFGMMI
What is the function of this protein?
Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system).
What are the official names of this protein?
Citrate-sodium symporter, Citrate carrier protein, Citrate transporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:citrate (SCF) symporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLSX_BRUAB
Sequence: MIKISIDAMGGDFGPEVVIPGAAKAFERHPDIRFIFFGLPAQVEPVLARYPKLKEASEFRASEVAIGMDDKPSQALRAGRGKSSMWQAIEAVKTGDADACVSAGNTGALMAMSKFCLRMMSDVERPAIAGIWPTLRGESIVLDIGATIGADARQLVDYAVMGAGMARALFEVRKPTVGLLNVGTEEVKGLDEIKEAGQILRDTPLDGLEYSGFVEGNDIGKGTVDVVVTEGFTGNIALKTAEGTARQMAELLRQAMSRTLLAKIGYVFAKGAFDRLREKMDPNKVNGGVFLGLSGIVIKSHGGANAEGFCSAVEVGYDMVRNRLLEKIEADLAHFHHSHSHVSSKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ANRX_NOSS1
Sequence: MTQKRPYEHRKAQKQVKNLESYQCMVCWEVNSKANGHHLIPYSEGGSADIQNMMTLCPSCHTKYHKGELKIDIHRF
What is the function of this protein?
Putative P-450 reductase.
What are the official names of this protein?
Anaredoxin, Putative HNH nuclease.
What is the protein family that this protein belongs to?
Belongs to the HNH nuclease family.
Protein: TMM92_HUMAN
Sequence: MSQAWVPGLAPTLLFSLLAGPQKIAAKCGLILACPKGFKCCGDSCCQENELFPGPVRIFVIIFLVILSVFCICGLAKCFCRNCREPEPDSPVDCRGPLELPSIIPPERVRVSLSAPPPPYSEVILKPSLGPTPTEPPPPYSFRPEEYTGDQRGIDNPAF
What are the official names of this protein?
Transmembrane protein 92.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TGT_FRATF
Sequence: MTVMKFDLIKKEGKARRGKITFPRGDIQTPAFMPVGTYGAVKSLSPVELKEMGAEIILGNTFHLWLRPGTEIIKKHGSLHGFNGWDKPILTDSGGFQVFSLGKMRKLTEEGVTFKSPVNSSKVFLSPEISMQVQRDLGSDIVMCFDECTPYPATEKEAKESMELSMRWAKRSKEAHGDNPSALFGIIQGGMYEHLRDESLAKLKEIDFDGFAIGGLSVGEPKEDMIRILDHTAHQMPEDKPRYLMGVGTPKDLVEAVYRGVDMFDCVMPSRNARNGHIFTSEGVIKIRNSKYKDDTSPLDPNCDCYTCKNFTKSYLHHLDKTKEILGSRLNTIHNLTFYQNLMKSIRKALDEGRFSEFRKEFLASYK
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TNFL8_HUMAN
Sequence: MDPGLQQALNGMAPPGDTAMHVPAGSVASHLGTTSRSYFYLTTATLALCLVFTVATIMVLVVQRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD
What is the function of this protein?
Cytokine that binds to TNFRSF8/CD30.  Induces proliferation of T-cells.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 8, CD30 ligand, CD30-L.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: LYEL_HALVD
Sequence: MSADMAAQSESGEGGDDGRADGGLGDRLVYLAVLSRPRFWLYLAGPVVVGVAAAASALADLFGLEPVALFAYFLVPANVFLYGVNDVFDADVDEANPKKDDREARWRGDPVNTVVVAASGLLGVGLFAVAPRVAWPWLAAHFFLAVEYSAPPFRFKTTPLLDSVSNGLYVLPGVAAYAAVSGSNPPMLAVAGAWLWTMGMHTFSAIPDIEPDREAGIRTTATALGERRTYWYCAATWVLAAVAFAAVDLRLGALLAAYPVVVLGIVAAGVDVDRAYWWYPVINTVVGMLITLGALWRLVNG
What is the function of this protein?
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR) (PubMed:21840984).  Acts as a bifunctional elongase/hydratase that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the previous end of the molecule (By similarity).  The enzyme acts at both ends of the substrate, and catalyzes the conversion of lycopene to the C(45) intermediate dihydroisopentenyldehydrorhodopin (DH-IDR) and the conversion of isopentenyldehydrorhodopin (IDR) to the C(50) carotenoid dihydrobisanhydrobacterioruberin (DH-BABR) (By similarity).  Can also catalyze the conversion of lycopene to tetrahydrobisanhydrobacterioruberin (TH-BABR) (By similarity).
What are the official names of this protein?
Lycopene elongase/hydratase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTMO_PENSI
Sequence: MKHNLPADLVTLWRDSPGYESARSRTFNQRIPPELPYAIVRPKNMEQIQHAVQLAVDLDKQIRIRSGGHSLAGWTLCADSILIDLVDFRHLEYDATTAIASASPSATSAQLNDLLVPHGRFVPVGHCGDVGLGGFFLQGGMGLNCRSYGWACEYLVGVDLITADGEYKHCSESENADLFWAARGAGPEFPAIVTRFFIRTRPAAAKYEKSTFIWPVACSDAVVSWILKILPELHADIEPLVVSTIVPGLNVAAILVQFLVFLSTNETGAEKLGPSLTAMPDGTLMEFKGVPTSIQQEYVSQEGTMPRDSRYICDSVWFKDGIDFVTVTRRMFREFPRDRSMVYWEPKYPTSRRQLPDMAFSLQADQYLALFAIFEDSQQDEEQGIRIQEFIQEIEPYVLGTFAADGMPAVRKTQYWSAEVIERLYSVCQKWDPAHRLGCTLLDPTRKVKS
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
FAD-linked oxidoreductase ptmO, Penitrem biosynthesis cluster 2 protein O.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: GSH1_AZOVD
Sequence: MSELFSRRLALLGEPANQSLLRHCLHGIERECLRVDAAGELARTPHPAALGSALTHPYITTDYSEALLEFITPAETDSAATLAALERVHRFACAKLDGEYLWSPSMPCPLPAEEDIPIARYGNSHIGRLKHVYRKGLALRYGKTMQCIAGIHYNFSLPEELWPLLQRAEGDVRGVRGVRDFQSERYIALIRNFRRYSWLLMYLFGASPALDKSFLRGRPHHLQELDAETLYLPWATSLRMSDLGYHNNAQADLTPCYNDLASYTDSLRRAVSTPYAPYAAIGTQRDGEWLQLNTNVLQIENEYYSTIRPKRVTASGERPIQALVARGVQYVEVRCLDIDPFLPLGIDLDEARFLDAFLLFCALEDSPCLAAGECASCTGNFLKVVKEGRRPGLHLQRHGQPMPLAAWAGELLERLQPLAALFDRAYGGDGYEKALHAQQAKVADPELTPSARLLATLRERGESFRAFALRQSLAHAESLRARPLGEEERQAFEAEARASLAEQAELERRDTGSFDDFVAAYQASIQGDGG
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: METK_MYCS2
Sequence: MSKGRLFTSESVTEGHPDKICDAISDSVLDALLEQDPKSRVAVETLVTTGQVHVAGEVTTTAYADIPKIVRDRILDIGYDSSTKGFDGASCGVNVAIGAQSPDIAQGVDTAHETRVEGKADPLDLQGAGDQGLMFGYAIGDTPELMPLPIALAHRLARRLTEVRKNGVLDYLRPDGKTQVTIQYDGTTPVRLDTVVLSTQHADGIDLEGTLTPDIREKVVNTVLADLGHETLDTSDYRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPAKIEKAIGEVFDLRPAAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQTNKVDDLKSAI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O265_CONLI
Sequence: MEKLTSLLLVAALLMLTQTLIQGGGEDRPNKKFLQKIKSTAKRECTAPSGYCDYPEECCEVECGRHYCDWWY
What are the official names of this protein?
Conotoxin LiC53.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYL_CAMC5
Sequence: MAQNSKYEAAKIEKKWQEIWHKNGEFEPKDDYTLPKKYILSMFPYPSGRIHMGHVRNYSIGDALARYYRKNCFNVLHPIGFDSFGMPAENAAIKHKIHPKKWTYENIDYMKKELSSLGFSFSDRRMLATSDPLYTKWEQSFFIKMFEKGLVYRKSAIVNWCEHDQTVLANEQVEDGCCWRCGNEVVQREFPGYYFKITQYAEELLNDLKTLEGKWPNQVIAMQENWIGKSSGLEFKFYLDDASSRALGGKFDGFEVFTTRPDTIYGVSYVALAPEHKVVRALLSSEILDDTKKAKIKSILNQSPRERQASDKDGVFLDIYMLHPLTNEPVPVWVANFILADYGSGAIMAVPAHDQRDYEFASKFGLPIKQVVMPKEGKFDTSKANAEYGISINSPLINGLETKQAKQAIIEKFEKDGLGKRITNYKLRDWGISRQRYWGAPIPIVHCPNCGVVPENEQNLPIALPDDVVITGEGNPLDKHPTWKYTKCPKCGHDAVRETDTMDTFVESSWYFARFASDEKTWQQTAFDKKSVDYWMSVDQYIGGIEHAILHLLYARFFQKVLRDLGYLRDDEPFSNLLTQGMVLKDGKKMSKSKGNVVDPDDIINRYGADTARLFILFAAPPQKELEWNDSAVEGAYRFLNRLWDKAKTIKKSEILPAIEHANLNKDEKYARMKVYEALKKSNEVFNETFAFNTLIAACMEALNALNAQDNDDVNTEGFFIILNLLEPIVPHIANELSEELFRRKNFTKLEILEEVFVKDTINLAVTVNGKKRAEFEISADASEADVLQTAKASVAKWIEGKEIIKEIYIKGKLVNLVVKG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.