Protein: ASCC3_RAT
Sequence: MALPRLTGALRSFSNVTKQDNYNEEVADLKLKRSKLHEQALDFGLSWKKIVKFLNEKLEKNKMQTINEDLKDILQAAKQIVGTDNGNEAIESGAAFLFMTFHMTDSVGYTETKAIRQMFGPFPSSSATSACNATSRIISHFSQDDLTALVQATENQCNDRVVFGRNLAFSFDMHDLDHFDELPVNGEAQKTISLDYKKFLNEQFQEPYTPELKPVEKSNGSLLWCEVEKYLNATLKEMTEAPRVEDLCCTLYDMLASAKSGDELQDELFELLGPGGLDLIEKLLQNRITIVDRFLNSSSDHKFQVLQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDGEVSGEGLLPFDPKELRLQREHALLNARSAPILGRQRDTEVEKIRYPHVYDSQAAARETSAFIAGAKMILPEGIQRENTKLYEEVRIPYSEPMPVGFEEKPVYIQDLDEVGQLAFKGMKRLNRIQSIVFDTAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFHQGVLKKNEFKIVYVAPMKALAAEMTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGRFRPVPLGQTFLGIKSANKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNSGQISCFLPTQGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVKWMSYTYLYVRMRANPLAYGISHKAYQMDPTLRKHREQLLIEVGQKLDKARMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSVLPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLRVSLNIYPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPVTALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKIRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSYVQQVNILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQESHTHCPDRPCLLLPERMLSSMTKLELIAFLATEEDPKQWLNMDEQEMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSQDAINKFLSHLIGQSLVELELSHCIEVGEDNRSIEPLTCGRIASYYYLKHKTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAASQGWLVTTLNITHLIQMVIQGRWLKDSSLLTIPNIEQHHLHLFRKWKPPVKGPHAKCRTSIECLPELIHACEGKEHVFSSMVEKELQPAKTKQAWNFLSHLPVINVGISVKGSWDDSVEGHNELSISTLTADKRDENTWIKLHADQQYVLQVSLQRVHFEFHKVKHESHAVTPRFPKLKDEGWFLILGEVDKRELVAVKRVGFVRTHHEASISFFTPEAPGRYIFTLYLMSDCYLGLDQQYDIFLNVTKADISTQINTEVPDVST
What is the function of this protein?
3'-5' DNA helicase involved in repair of alkylated DNA.  Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions.  Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.  Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex.  Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm, cytosol. Note=Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.