Protein: ATR_CAEEL
Sequence: MNIDKDVSALLCTAKKYVTQKEFNRQKMKFLLDDITKLLSKSFVSRIEQLDENEFMEKIMILQSITFTLHLITEKQELSSEEKIRLFQSVIASMCAFEDEELAKCFDRILSVLMISVTKQDPRETIYFLQGLLEVVKYCDVEPSSSLPQLITPEIASAISLGASGFFRYHLKWNIISTLFGENAGECVHFDELVLFWPHCRSQLEDKLKNDCSMTENCLRAGLTILKYKKLHNSILDQALFIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDHGKVLIMHKELRQKPVQWLIIYLELIDDANDKFGLLENFSLLLLDLSTNHDIHEFPARLCMTASEICMRRIKHSIQSTHTDCLADYLDILASLLKLARIQKLDIFQCFATEIEAHHSLNNPLWPRILRSLLSVQNPHCQQFCKKFVPSIDKLWITLLNGESSRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQDFRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVLERSTSESTKLRAVNCALQLEKKTGKYINLVAEMSLAVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTLQKLFCLAANGRNSCKKCGEECFVDPDSKENVKIDYESLSGLIKGIVARRNTFSQELIREFLQTSRVMLLHVDSKGIASSFTSIIKALDIGFSENANAYFRVWELVCCRSEATVEKKLQMYIPLIGRSFALLGDDAALKVHGFLSNVLSARLSSTVKATLFASSFAHSVLKNCEIDWNVSYTWKTQFSQCLIKAPVGTCEEALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSYDEHRIREITRCYLSHVLSDFNFPNQKITFNMIRPSLLYWSLLSSARGINSKLTLSVIDFICQEMSAASVSMSSISPNPSDIRIVMIQRKSLITETFAQLVQFLAFENNRNTTSFWKFCSDHCDFKDEDIRTVISSYRKQVFMHLLLVSAREFLNPRNPSMIVEQLRATYENIKKGEKFMISTAIETRNEGIEFLFIFRTYFTNDQYFLTREATAESFRILLQNMKQDFFDTNWYIILMTLRQIPLNLDSTQSSWISFIEQINYSILRSNIWRILTDISRIENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWLIPLEVEKRIDLKFEISKSRQIEDVLEFIRMFPQYPSVQFADNLASKIERKTVYKEELPKLIGSLSRILPQCHSKREQNKIIKILQKLPIICSDLPDHNFIRWDTRFKFFCEPRQLTQAVLEDCAGIVEVMTGTSKIEYVDRTMCEIYKFFNPNEASPEMKSTLDGIKNMYAKMICSQKPEPSMIEQKTIDELSLGGSRRESFSRWLTVIILKCAEMSEDAPLSSLASIAHVDDTRFLSKLAMRFILTVIHMERDSVTQWILSTFEEALTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKVISFWKSMMSWTFKDENGHGQPLIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESETEAAYYFTLMNLYGRIHELNGVRGAYARLSRIQIDHVYGKISMREAFGDFNSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTLSQWVNIDNDIGPSPHIFSRNIEYWATESTILKMIRNDERDEIVNNAIENAKSKVIERLSECAIGGSCSYEIATPFLVELQKLNEIVELKNVSNDELSAFNSDFWKNIQKRTDDSEQKISILEPILRVRRSMLDIRMQSMTGRDKENIRSRIVEVHLQSARIARLTGCFERAQLSLINAKKVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDVQKSAKLKIEHYQEETKNLFSSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMYEAAWLLDYLSNYKERSKHVLPLLKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLPEGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLSEKVDGLKTMFRDKKYDPKELVMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEESCHLPDRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGWMATL
What is the function of this protein?
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity).  Recognizes the substrate consensus sequence [ST]-Q (By similarity).  Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity).  Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the checkpoint response to double-strand breaks (DSBs) after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1/p53 pathway (PubMed:12747829, PubMed:16319925).  In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).
What are the official names of this protein?
Serine/threonine-protein kinase ATR, ATM-like protein 1, Ataxia telangiectasia and Rad3-related protein homolog, ATR homolog, Ce-atl-1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to stalled replication forks by rpa-1-coated single- stranded DNA. Recruited to processed double-strand breaks in a rpa-1 and mre-11-dependent manner.