PharMolix/UniProtQA huggingface dataset:
Protein: PTGDS_RAT
Sequence: MAALPMLWTGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKELLFMCQTVVAPSTEGGLNLTSTFLRKNQCETKVMVLQPAGVPGQYTYNSPHWGSFHSLSVVETDYDEYAFLFSKGTKGPGQDFRMATLYSRAQLLKEELKEKFITFSKDQGLTEEDIVFLPQPDKCIQE
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10387044, PubMed:10650953, PubMed:11058225, PubMed:9188476).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: TRS23_SCHPO
Sequence: MHALIIINRAGSLIFQREFGSSPTALTPNEYLVLAGTIHGVHAISTQISPLPGSSGIQLLEAGTFNMHILQTHTGMKFVLFTEKKTTNARLQLQKFYELYSDYVLKNPFYTLEMPIKCQLFDEQLKRYIDSH
What is the function of this protein?
TRAPP plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
What are the official names of this protein?
Transport protein particle subunit trs23, TRAPP subunit trs23.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm. Nucleus.
Protein: GAG_HV2ST
Sequence: MGARNSVLRGKKADELEKIRLRPGGKKKYRLKHIVWAANELDRFGLAESLLESKEGCQKILTVLDPLVPTGSENLKSLFNTVCVIWCIHAEEKAKDTEEAKQKVQRHLVAETKTTEKMPSTSRPTAPPSGNGGNFPVQQVAGNYTHVPLSPRTLNAWVKLVEEKKFGAEVVPGFQALSEGCTPYDINQMLNCVGDHQAAMQIIREIINEEAADWDAQHPIPGPLPAGQLREPRGSDIAGTTSTVEEQIQWMFRPQNPVPVGSIYRRWIQIGLQKCVRMYNPTNILDIKQGPKEPFQSYVDRFYKSLRAEQTDPAVKNWMTQTLLVQNANPDCKLVLKGLGINPTLEEMLTACQGVGGPGQKARLMAEALKEAMAPAPIPFAAAQQRRTIKCWNCGKEGHSARQCRAPRRQGCWKCGKAGHIMAKCPERQAGFLGLGPWGKKPRNFPVAQIPQGLTPTAPPIDPVEDLLEKYMQQGKRQREQRERPYKEVTEDFLQLEKQETPCRETTEDLLHLNSLFGKDQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: COAD_DESVV
Sequence: MDDERGKLAVYPGTFDPLTMGHVSLIRRGRQIFDRVIVAVAMDTPKTPLFSLDERVRMAEEVFADHEGITVEPFSGLLVDYAERRGANVILRGLRAVSDFEYEFQLALMNRKLKRHVQTVFLMTDYQWLYISSTIIKAAASLGGDIKGLVPDNVYRRLREKYGYPYPLNPGLALSTEADEDLPPSL
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_SALPC
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIDDDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKKLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKLKPQIQEEEQHG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP7_PROMU
Sequence: MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHPFLVLVYYDDYQCGGTLINEEWVLTAAHCNGENMEIYLGMHSKKVPNKDRRRRVPKEKFFCDSSKNYTKWNKDIMLIRLNRPVRKSAHIAPLSLPSSPPSVGSVCRIMGWGTISPTKVTLPDVPRCANINLLDYEVCRAVYPELPATSRTLCAGILEGGKDSCGGDSGGPLICNGQFQGIVSWGGDPCAQPHEPGLYTNVFDHLDWIKGIIAGNTDVTCPL
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease serpentokallikrein-2, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RRP42_THEVO
Sequence: MVKESAEILSEIRKNYILTTMKGGKRIDGRLPDEFREITIIENYVPRANGSAYVALGKTRVVAGVKIEAGEPFPDTPDQGVLTTNVELLPIAFPSFEAGPPNDLAIEVSRVVDRGIRESKMISPDKLVIEQGKKVWIVFLDINVLDYDGNLIDACTIAAVSALRNAIVPASREGGEDFKLPVVNTPISVTMVKIGDTLVCDPSLEEDQICGGRITVTTTEDGHIRAMQKGEIGVFTLDDVKKAIKMSLKVGKNIREKYFR
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACUB_BACSU
Sequence: MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHVIGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHGIGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQDLQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL
What is the function of this protein?
Role in growth and sporulation on acetoin or butanediol.  Involved in the breakdown of these compounds used as a carbon source.
What are the official names of this protein?
Acetoin utilization protein AcuB.
Protein: RL22_LACLA
Sequence: MAEITSAKATAKTVRVSPRKTRLVIDLIRGKRVADAIAILKFTPTKAAVEVENVLNSAIANAENNFGLEKANLVVSETFINEGPTMKRFRPRAKGSASPINKRTAHITVVVAEKE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DBP2_PICST
Sequence: MNNYNNGDYKGGREQHFGGNNNYNRGYGGNGGFGGNRYNERVELTTPDWDLESLPKFEKNFYTEHPDVAARSDKDIAAFRNEHQMSCLGSDIPHPITTFDEAGFPEYVLNEVKAQGFPSPTAIQCQGWPMALSGRDMVGIAATGSGKTLSYCLPAIVHINAQPLLSPGDGPVVLVLAPTRELAVQIQQECSKFGSSSRIRNTCVYGGAPKGQQIRDLARGVEIVIATPGRLIDMLEMGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVQNLARDYLQDPIQVRIGSLELAASHTITQVVEVISEYEKRDRLVKHLETATTEKESKVLIFASTKKTCDEVTSYLRADGWPALAIHGDKQQSERDWVLREFKTGKSPIMVATDVAARGIDVKGINFVINFDMPGNIEDYVHRIGRTGRGGATGTAVSFFTDGNNKLGGDLCKIMREAKQTIPPELQRFDRKSFGAHIRYGGGRGGRGGYGRGRGGYGGRGGYGQRNYQTGSNQAPLSNRRF
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DUT_YERE8
Sequence: MKKIDIKILDPRVGNEFPLPTYATEGSAGLDLRACLSEAVDLLPGQTTLLPTGLAIHIGDSSLAAVILPRSGLGHKHGVVLGNLVGLIDSDYQGQLMVSVWNRGQQPFTIEPGERIAQMVFVPVIQAEFNLVEDFDLSERGTGGFGHSGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: BIOB_CORGB
Sequence: MTIPATILDTARTQVLEQGIGLNQQQLMEVLTLPEEQIPDLMELAHQVRLKWCGEEIEVEGIISLKTGGCPEDCHFCSQSGLFESPVRSVWLDIPNLVEAAKQTAKTGATEFCIVAAVKGPDERLMTQLEEAVLAIHSEVEIEVAASIGTLNKEQVDRLAAAGVHRYNHNLETARSYFPEVVTTHTWEERRETLRLVAEAGMEVCSGGILGMGETLEQRAEFAVQLAELDPHEVPMNFLDPRPGTPFADRELMDSRDALRSIGAFRLAMPHTMLRFAGGRELTLGDKGSEQALLGGINAMIVGNYLTTLGRPMEDDLDMMDRLQLPIKVLNKVI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GATA_DESVH
Sequence: MSALHTLSLAAIRDALARREVRAEDAVLDCLARIETTEPRIDALLHLRAEAAIEEARALDAAGPDASRPLWGVPVTVKDALTTAGTPTTAGSRILEDFVPFYDAFAVQRLREAGAIILGKNNMDEFAMGSSTENSAYKPTRNPWDTARVPGGSSGGSAASVAAGQCFASLGTDTGGSIRQPASLCGCVGLKPTYGRVSRYGLIAYGSSLDQIGPMTRTVEDAAIVMGVIAGHDKRDSTCADRPVEDFAAALASRHDLAGVRIGVPAEFWGEGLSPEVATSCRAALDAARDLGATIVDVALPHTPQSIAAYYIVASAEASSNLARYDGVRYGKRAHAPEDLMDLYVRSRSEGLGDEVQRRIMLGTYVLSSGYYDAYYRKAAQVRRRILEDYRNAFATCDVICGPVSPVTAWPLGALTADPLQMYLMDVFTLSLNLAGLPGLSLPVGLGTESGMPVGIQLLGRSFDEATLLSVGNVLSRALPPLGSPAGLR
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RPOC_XYLFT
Sequence: MKDLLNLFNQQRQTLDFDAIKIGLASPALIRSWSFGEVKKPETINYRTFKPERDGLFCAAIFGPIKDYECLCGKYKRMKHRGVVCEKCGTEVTLAKVRRERMGCIELASPVAHIWFLKSLPSRIGLMLDMTLRDIERVLYFEAYVVTEPGLTPLERRQLLTEEQYLQARQEHADDFDASMGAEAVYELLRMIDLQSEMARLREEIVVTGSETKLKRLTKRIKLIEAFIESGNRPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLCRLLELSAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSARSVIIVGPNLRLHQCGLPKKMALELFKPFVFAKLQRRGLATTIKGAKKLVEREEAEVWDILEEVISEHPVVLNRAPTLHRQGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMSRALENKKGEGMVFANTSELKRAYDNSVVELHAKVKVRITEIETDDQGLRNKASSIVDTTVGRALLSEILPEGLPFVLVNTEMTKKNISRLINSSYRMLGLKETVVFADKLMYTGYAYATRAGVSICIDDMLIPIEKKEILGEAEQEVLEIQEQYQSGLVTAGERYNKVVDIWSRTNERIAKAMMDTIGTERVVNADGEIVDQKSMNSLYIMADSGARGSPQQIRQLAAMRGLMVRPDGSIIETPIKANFREGLSVQEYFNSTHGARKGLADTALKTANSGYLTRRLVDVTQDLCVVQLDCGTAGGLTMTPIVEGGDVVEPLKDRVLGRVVAEDVLLPGNDDEPIVTRSTLLDEQWVAKLEEAGVQSVKVRSPITCESPFGVCALCYGRDLARGHLVNMGEAVGVIAAQSIGEPGTQLTMRTFHIGGTALSAAAIDNITVKTSGSVKFTNLKYVEHANGTLVAVSRSGEISVLDTHGRERERYKLPYGATINVKDMAEVKSGQILANWDPHNHPIVSEVAGFVRFIDFVDGVTVIEKTDDLTGLSSREIADLKRRGSQGKDLRPLVRIVDKKGNDLTIPGTDLSAQYLLPPRSIVNLQDGAPVGIGDVVAKIPQEASKTRDITGGLPRVADLFEARRPKDPAILAERSGVISFGKDTKGKQRLIIKDADGSEHEELIPKYRQIIVFEGEHVTKGETIVDGEPSPQDILRLLGIEPLAAYLVKEIQDVYRLQGVKINDKHIEVITRQMLRKVEIVDQGNSKFLNGEQVERQRVIDENAKLIARNELPAKYNPVLLGITKASLATESFISAASFQETTRVLTEAAVRGTRDNLRGLKENVIVGRLIPAGTGQTYHSQRRYSSVGLTESEMETLVGRSTSSGTEVTSPSKDAIPLGG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: MSRA_ACIBC
Sequence: MQQALFGGGCFWCVEAVFLQIRGVEKVTSGYAGGHTTHPTYEQVCQGDTQHAEVVLIDFDEQQVTYSQLLDVFFATHDPTTLNRQGNDIGTQYRSVIYYFNEEQKQAAEHTIQTLKDDDLDIVTELSPAPTFYPAEDYHQNYYEKNPSQGYCNFAIPPKLLKLHSKFQHLMKN
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RL20_HYPNA
Sequence: MPRSRAKVPAHARHKKIIKQAKGFRGRRKNTFSNAAAAVWKAGEYAYVGRKVKKRSFRSLWIQRINAAVRIHDENLNYSTFINGLTKAGIEVDRKVMADLAVREPEAFGALVAQAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RHAS_PECAS
Sequence: MTLLRGDDFFTSRAVTVAVEPRTPQTAFPEHYHDFWEIVLVEQGAGVHVFNDQPYALCSGSVFFVRDNDRHLFEDVEGLCLTNMLYRSPRGFRFLSDIAAFLPYGPNGEWQGQWQVNAAGMQQLKQSLNSLAGLAQSDAPEAIAASESLFLQILVQLRQHCFQTEGNGSERQGVQALLGWLQNNYSEEVNWGGLADQFSLPLRTLHRQLKQHTGMTPQRYLNRLRLLEARRRLQQSDDSITTIAHACGFSDSNHFSTQFRKAFSQAPKSLRHQAFSREE
What is the function of this protein?
Activates expression of the rhaBAD and rhaT operons.
What are the official names of this protein?
HTH-type transcriptional activator RhaS, L-rhamnose operon regulatory protein RhaS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH1_GEOBU
Sequence: MSTAGKVIKCRAAVLWEKNKPFSIEEVEVAPPKAYEVRIKIVATGICRSDDHVVNGSIITPLPAILGHEAGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCKHGDLGRAQGTLMDGTSRFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDATSPLEKVCLIGCGFSTGYGSAVKVGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQDYDKPIYQVLQEMTDGGVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMDPMVLLSGRSWKGAVFGGYKGKDDVPKLVADFMAKKFPLEPLITNVFPFAKINEGFDLLRAGKSIRTVLTF
What are the official names of this protein?
Alcohol dehydrogenase 1, Alcohol dehydrogenase A subunit.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMI_CAMFF
Sequence: MLYFLPTPIGNLDDISKRCLDVLELCEIIICEDTRVTKSLITLLNAKFGLQISPKEFYSLHTHNEKDFFDKFDKVRLETKICIYASDAGMPCISDPGISLVKFAQQNSIKYEVLSGANALLLAAAASGIIEKEFTFLGFLPNLGKERAIAIQNALNSLYPVIIYESPKRILSLIKSISEFDPLREVFIIKEATKKFEAKFKNSATNLLTQLENSNLNGEWCVVIDRSANKALERITTKDIMELDLPLKQKAKLISKITGENAKKIYQNLIT
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_HAEIN
Sequence: MNILIIGNGGREHALAWKVAQSPLADKVFVAPGNAGTALEHKVENVNISATDIPALVKFAQDKQIGLTIVGPEAPLVIGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEAGSRVVIEEFLDGEEASFIVMVDGKNVEPMASSQDHKRVGENDTGLNTGGMGAYSPAPVITPEIHSRIMKEVIYPTVNGMAAEGNVYTGFLYAGLMIMPNGQPKVIEFNCRFGDPETQPIMLRLKSDLVELCLKACDGKLDEVISQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSAVKNEKVFLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGRFYRRDIGYRAVERELQK
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: CMTR_NPVAC
Sequence: MLQQKLNKLKDGLNTFSSKSVVCARSKLFDKRPTRRPRCWRKLSEIDKKFHVCRHVDTFLDLCGGPGEFANYTMSLNPLCKAYGVTLTNNSVCVYKPTVRKRKNFTTITGPDKSGDVFDKNVVFEISIKCGNACDLVLADGSVDVNGRENEQERLNFDLIMCETQLILICLRPGGNCVLKVFDAFEHETIQMLNKFVNHFEKWVLYKPPSSRPANSERYLICFNKLVRPYCNNYVNELEKQFEKYYRIQLKNLNKLINLLKI
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of late viral transcripts.
What are the official names of this protein?
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase.
Protein: VILI_PIG
Sequence: MTKLNAQVKGSLNVTTPGVQIWRIEAMQMVPVSSSTYGSFFDGDCYIVLAIHKTGSNLSYDIHYWIGQDSSQDEQGAAAIYTTLMDDFLKGRAVQHREVQGNESEAFRGYFKQGIVIRKGGVASGMKKVETNSYDIQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLRGMTLAKEIRDQERGGRTYVGVVDGEDEKASPQLMEIMNYVLGQRKELKAAVPDTVVEPALKAALKLYHVSDSEGKVVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKNANPQEKKEAMNQALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTVPNQTSGLGKTHTVGSVAKVEQVKFDATSMHVQPQVAAQQKMVDDGSGEVEIWRIENLDLVPVESKWVGHFYGGDCYLLLYTYLIGEKQHYLLYIWQGSQASQDEITASAYQAVILDQKYNNEPVQIRVPMGKEPPHLMSIFKGRMVVYQGGTSRANSTEPVPSTRLFQVRGTSVNNTKAFEVPARATSLNSNDIFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWVALGGKAPYASSKRLQEETLVITPRLFECSNQTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKNANEDEKKAAAVTAQEYLKTHPSGRDPETPIIVVKQGYEPPTFTGWFLAWDPFKWSDSKSYEDLKAELGNSGDWSQITAEIKNPKPDVFNANTNLSSGPLPIFPLEQLVNKPAEELPQGVDPSRREEHLSIEDFTKALGMTPAAFSALPRWKQQNLKKEKGLF
What is the function of this protein?
Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments.  Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing.  Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2.  Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities.  Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity.  Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis.  Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium.  Appears to regulate cell death by maintaining mitochondrial integrity.  Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity).
What are the official names of this protein?
Villin-1.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip. Cell projection, filopodium. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity).
Protein: FENR_CHLPB
Sequence: MKENGDSVSGQDELCDLTIIGGGPTGIFAAFQCGMNNISCRIIESMPELGGQLTALYPEKHIYDVAAFPEVQASELVESLWGQAKRYDPEVVLDEQVRQYKKLDDGSFEVETLSGRTFASRALLVAAGLGAFSPRKLPQLGDISELEGHTVLYSVQNMKELEGKKVLIVGGGDSALDWAMMLLPHAEHITVAHRSPDFRAHGKTKDDLFAAAEKGLVDVHLNTEVIAIDHDGPALRHAYLRSKSGKETSLEAEYMLVLIGFKSDLGPLAEWGLELCENAMVVDSQMKTEVDGLYAAGDIAYYPGKLKIIQTGLSDATMAVRHCLNYIHPGEKIKQQFSSIKMAKEKNK
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: RL1_ECODH
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: Y2420_DESHY
Sequence: MDRLEHTMMFKSQGGDVSPQEILQQVYVALEEKGYDPINQLVGYLMSGDPVYITSHNQARSLIRKLERYELLEELVRSYLQEK
What are the official names of this protein?
UPF0297 protein DSY2420.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: MITD1_HUMAN
Sequence: MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI
What is the function of this protein?
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
What are the official names of this protein?
MIT domain-containing protein 1.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.
Protein: RS16_LEPIN
Sequence: MVKLRLQRTGTKHDPHYRIVAADSRSPRDGKFVDIVGHYHPAQIKEQTTFNKEKILTWLKNGAQPTGTVLNLFKNAGIWAEYKTTLKK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL21_MESM1
Sequence: MFAIIETGGKQILVKKDDFIFIEKIEGEAGQNVVFDKVLLVDDKIGTPFLKNATVTGIIEKQGKQKKIVVYRHNAKSTHKRKLGHRQPYTRVKILEIKG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.