PharMolix/UniProtQA huggingface dataset:
Protein: RICTR_MOUSE
Sequence: MAAIGRGRSLKNLRIRGRNDSGEENVPLDLTREPSDNLREILQNVAKLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQKAIATHHKRDQYLRVQKDIFVLKDTEEALLINLRDSQVLQHKENLDWDWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYASLDLDLAKSKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKYVDLIEEQLNEALTTYRKPIDGDNYVRRSNQRLQRPHVYLPVHLYGQLVHHKTGCHLLEVQSIITELCHNVRTPDLDKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWDSVRHSRKHLWPVVPDDVEQLCNELSSVPSTLSLNSESTSSRHNSESESAPSSMFMLEDDRFGSTSTSTFFLDINEDAEPAFYDRPGPIKDKNSFPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSSAQKSLQLEPSFVGNKHLEDAGSTPSIGENDLKFPKSFGTETHRENTSRERLVVEGSASSHIKIRSQSFNTDTTTSGISSMSSSPSRETVAVDPTAMDTDCGSLSTVVSTKTVKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINHNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQIKDVPYFQSKHVPPPDDRGARMFSHDGAGLSSGAGGLVKNSFHLLRQQMSLTEIMNSVHSDASLFLESTEDTGLQEHTDDNCLYCVCIELLGFQPSNQLSSICSHSDLQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGASQEEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVVNLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLQCRRFIQELFQDVQFLQMHEEAEAVLAIPPIQPIVDESAES
What is the function of this protein?
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.  mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.  Plays an essential role in embryonic growth and development.
What are the official names of this protein?
Rapamycin-insensitive companion of mTOR, AVO3 homolog, mAVO3, Protein pianissimo.
What is the protein family that this protein belongs to?
Belongs to the RICTOR family.
Protein: TAP2_ANTMA
Sequence: MAKSSPTYTVLFLLGLLALSTATTTFQNEGQRSLIGQFNSRGTFKKIKNHPSESVQRSNEDFAMHKTKLKHKFVARSGGETDVKKMEGSMPDQGKTAGRDQQVTVQNIKEASKENVGGNTNDIYKSGGMHH
What are the official names of this protein?
Protein TAP2.
Protein: GPR33_HUMAN
Sequence: MDLINSTDYLINASTLVRNSTQFLAPASKMIIALSLYISSIIGTITNGLYLWVLRFKMKQTVNTLLFFHLILSYFISTMILPFMATSQLQDNHWNFGTALCKVFNGTLSLGMFTSVFFLSAIGLDRYLLTLHPVWSQQHRTPRWASSIVLGVWISAAALSIPYLIFRETHHDRKGKVTCQNNYAVSTNWESKEMQASRQWIHVACFISRFLLGFLLPFFIIIFCYERVASKVKERSLFKSSKPFKVMMTAIISFFVCWMPYHIHQGLLLTTNQSLLLELTLILTVLTTSFNTIFSPTLYLFVGENFKKVFKKSILALFESTFSEDSSVERTQT
What is the function of this protein?
Orphan receptor; could be a chemoattractant receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 33.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_SHEWM
Sequence: MHKRAIYPGTFDPVTNGHADLIERAAKLFQHVVIGIAANPSKQPRFTLDERVQLLKLVTAHLDNVEVVGFSGLLVDFAKDQQASVLVRGLRAVSDFEYEFQLANMNRRLDPDLESVFLTPSEENSFISSTLVKEVALHGGDVSQFVHPEVSKALLSKG
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAK4_MOUSE
Sequence: MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLIDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRESPPPPARAHQENGMLEERAAPARMAPDKAGSRARATGHSEAGSGSGDRRRVGPEKRPKSSRDGPGGPQEASRDKRPLSGPDVSTPQPGSLTSGTKLAAGRPFNTYPRADTDHPPRGAQGEPHTMAPNGPSATGLAAPQSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLMRQHRTR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival.  Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.  Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.  Decreased cofilin activity may lead to stabilization of actin filaments.  Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin.  Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility.  Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers.  Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD.  Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner.  Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
What are the official names of this protein?
Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.
Protein: MRAY_SPHAL
Sequence: MLYWLAEWLGFPGALNLIRYLSFRSGAAVATAMILGLWIGPRFILMLRMRQGKGQPIRDDGPQSHLAKKGTPTMGGLMILISLMISALLWMDLSNRFVWACLFVTAGFAVVGFLDDYDKVTKSSHRGIPGRVRLLVEFLIAGVAVLLIVSRTGTDLYLPFFSGIVIPLGPFYYVFAMVLIVGFGNAVNLTDGLDGLATFPVIIASLTFLVIVYLSGNVKFAGYLGIPHVPGAGELAVFAAAIIGACLAFLWFNAPPAAVFMGDTGSLALGGALATIAVTAQHELVLVLVGGLFVVEALSVIIQVFWYKRTGKRVFRMAPIHHHFEQLGWPESTVVIRFWIVSIVLALAGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCYA_PROMP
Sequence: MLSKSLTKTKLIDPLILTLLQNIKVQRSKLNDLNCIEVDPKLSNIISNEEGKELYIENEFYKAKGFRKLHIEVAEFSKSLKILHCVFFPDPKYDIPIFGMDLVKVNELVSAAIVDLSPSSKNQNLKYDHLLSHIDKSVFKSKREIPIWGNIFSKNVFFASLKNESEKNAFCKIVDNYLSVLIQLSQSTSPDSDYEIIEERINYQKNYCVQQMKNEKTSLVLLKYFDKVWVDEYIKKVLFDF
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: RL14_ALIF1
Sequence: MIQMQSTLDAADNSGARKVMCIKVLGGSHRRYAHIGDIIKVTVKEAIPRGKVKKGDVLKAVVVRTRKGVRRPDGSIIRFDRNACVLLNDTTEQPVGTRIFGPVTRELRNAKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYK_STRTD
Sequence: MPNQHMEELNDQQIVRREKMAALAEQGIDPFGKRFERTATSGQLKEKYADKTKEELHEINETATIAGRLMTKRGKGKVGFAHIQDRDGQIQIYVRKDAVGEENYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLSDIETIYRKRYLDLISNRESFDRFVTRSKIISEIRRYLDAQGFLEVETPVLHNEAGGAAAKPFITHHNAQNIDMVLRIALELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTMIEVYQAYADFHDIMDLTEGIIQHAAKAVKGDGPVNYQGTEIKINEPFKRIHMVDAIKEITGVDFWQDMTFEEAVALANEKHVPVEKHYTEVGQIINAFFEEFVEETLTQPTFVYGHPVAVSPLAKKNPEDPRFTDRFELFIMTKEYGNAYSELNDPIDQLSRFEAQAAAKELGDDEATGIDYDYVEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO_MYCBO
Sequence: MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx, MPT46.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: AZOR_XANOM
Sequence: MKLLHLDSSALGATSISRELSAAIVAQQRRLYPEVEVTYRDLDRDPIPHLTAQTLAQTDPAEAAAAEAVMQQFLQAEVIVIGAPMYNFAIPSTLKAWIDRIAVAGRTFHYTANGPEGLAGGKRLIIASARGGVYAEPSNDFQEPYLRQLFGFLGIDDITLVRAEGVAYSPQHRADALAAALAGLCAEQDAAVMA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: ACP_BACC0
Sequence: MADVLERVTKIIVDRLGVEETEVVPAASFKEDLGADSLDVVELVMQLEDEFEMEISDEDAEKIATVGDAVTYIESHL
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCAD_ECOSM
Sequence: MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDEQHLPYERPPLSKSMLLEDSPQLQSVLPAHWWQENNVHLHSGVTIKTLGRDTRELVLANGESWHWDQLFIATGAAARPLPLLDALGERCFTLRHAGDAARLREVLQPERSVVIVGAGTIGLELAASATQRGCKVTVIELAATVMGRNAPPPVQHYLLQRHQQAGVRILLNNAIEHVVDGENVELTLQSGETLRADVVIYGIGISANDQLAREANLDTANGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAASAMLGLPLPRLPPPWFWSDQYSDNLQFIGDMHGDDWLCRGNPETQKAIWFNLQNGVLIGAVTLNQGREIRPIRKWIQSGKTFDAKLLTDEDIALKSL
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: LEXA_RHIL3
Sequence: MLTRKQQELLLFIHERMKESGVPPSFDEMKDALDLASKSGIHRLITALEERGFIRRLPNRARALEVIKLPEAYSPSIQPRRGFSPSVIEGSLGKPQPVATPAPAKSVADNGNSVSVPVMGRIAAGVPISAIQNNTHDIVVPADMLGSGEHYALEVKGDSMIDAGIFDGDTVIIRNGSTASPGDIVVALVDDEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGKLVGLIRRYH
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RCAA_HORVU
Sequence: MAAAFSSTVGAPASTPTNFLGKKLKKQVTSAVNYHGKSSKANRFTVMAAENIDEKRNTDKWKGLAYDISDDQQDITRGKGIVDSLFQAPTGHGTHEAVLSSYEYVSQGLRKYDFDNTMGGFYIAPAFMDKLVVHLSKNFMTLPNIKIPLILGIWGGKGQGKSFQCELVFAKMGINPIMMSAGELESGNAGEPAKLIRQRYREAADMIKKGKMCCLFINDLDAGAGRMGGTTQYTVNNQMVNATLMNIADAPTNVQLPGMYNKRENPRVPIVVTGNDFSTLYAPLIRDGRMEKFYWAPTRDDRIGVCKGIFQTDNVSDESVVKIVDTFPGQSIDFFGALRARVYDDEVRKWVGSTGIENIGKRLVNSRDGPVTFEQPKMTVEKLLEYGHMLVQEQDNVKRVQLADTYMSQAALGDANQDAMKTGSFYGKGAQQGTLPVPEGCTDQNAKNYDPTARSDDGSCLYTF
What is the function of this protein?
Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4. 1. 1. 39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
What are the official names of this protein?
Ribulose bisphosphate carboxylase/oxygenase activase A, chloroplastic, RA A, RuBisCO activase A.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO activase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: IF6_METVS
Sequence: MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSLCVGNSNGLLVPNIVTSKEIALIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISEELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCLVHPLTDELELEWITDVLKVDYVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: INX11_CAEEL
Sequence: MVMIETFLGMAKYLSPREDDDWSDRLNYLMTPNILLAFSVLISFKQFGGRPIECMFPNKFPGSWEQYAENYCWSQDTYFVEPTQDVSLLKKEERYTPDRQLSYYQWVPFFLLLQAAFFRAPSYLWKYFSNHSGIRIHEVVEKAKDSANVEEEVREKNILILKRHLSSALRFQANMERKKVQVHKTVTFLNFQYSSGFISWIYLFTKVLYFLNVFAQLYLMNYFLGTNRHHWYGFGVVQDIVQGEPWERSGYFPRAAVCDFEVRQVANIQRYSVQCVLVINIFNEKIFVLLWFWYVILLLSSTVSLVQWFIVLVFPCFSKWFVKQHLALSTLQNFNQRNSRREDSDVSKFVTQYLHKDGVFVLRMVSSHAGIIFATDLVQALYEAYDFQDKNKDVQGSPVSDDLQTISTGAESSIRQRKTRKGSRIEYKAGFPISTSLMPDKDDIESSSTSSEEDQKRVSNVITNI
What is the function of this protein?
Structural component of the gap junctions.
What are the official names of this protein?
Innexin-11, Protein opu-11.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: GH34_ORYSJ
Sequence: MPEAVAAAVSPAAAAATAMCAEHREKLEHIERVTRNAGQEQRRVLEEILAQNAQAEYLRRLGVPGDAPGADEAFRRLAPLVTYEDILPDVLRIANGDTSPILSGKPVSEFLTSSGTSGGERKLMPTIEEEMERRSGLYSLLMPVMSRQVPGLDKGKAMYLYFVKSEWRTPGGLPARPVLTSFYRSRYFLERPHDPYTVYTSPDEAVLCEDAYQSMYAQLICGLVHRADVLRVGAVFASGFLRAIRFLEKHWPSLCRDIRAGELDGGVTDPAVRGAVGRVLRGADPALADAIEAECARPSWQGIIRRVWPSTKYIDVIVTGAMAQYIPTLEFYGGGLPLACTMYASSECYFGLNLNPMCKPSEVAYTLIPTMCYFEFLPVNSGANDVAAPEPDHRGLVDLVDVKLGHEYELVVTTYSGLYRYRVGDVLRVAGFKNAAPMFAFVRRKNVALSIDSDKTDEAELHAAVTEAVQHLAPFGASLVEYTSYADTATTIPGHYVLFWELRSPAGGTPVPASVFEDCCLAVEEGLNSVYRQCRAADRSIGPLEIRVVADGTFDKLMDYALSRGASINQYKAPRCVRPGPVVELLDGRVQATYFSPKCPKWCAGGNKQWISSGAAAKKTTTTCDSLAV
What is the function of this protein?
May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
What are the official names of this protein?
Probable indole-3-acetic acid-amido synthetase GH3.4, Auxin-responsive GH3-like protein 4, OsGH3-4.
What is the protein family that this protein belongs to?
Belongs to the IAA-amido conjugating enzyme family.
Protein: MDGA2_MOUSE
Sequence: MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR
What is the function of this protein?
May be involved in cell-cell interactions.
What are the official names of this protein?
MAM domain-containing glycosylphosphatidylinositol anchor protein 2, MAM domain-containing protein 1.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CHDC_BACCZ
Sequence: MSEATTTLDGWYCLHDLRSIDWAAWKTLSSDERGQAVSEFLNVVEKWNDVAAAKKGSHAMYTVVGQKADIMLMILRPTMEELNEIETELNKTTLAEYMVPAYSYVSVVELSNYLPADEDPYQNPQILARLYPELPKANHICFYPMDKRRQGDDNWYMLPMEERKKMMYSHSKIGRQYAGKVRQVISGSVGFDDFEWGVTLFADDVLQFKKLIYEMRFDEVSARYGEFGTFFVGNILPDEKVEKFLHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: VP7_ROTHE
Sequence: MVCTTLYTVCAILFILFIYILLFRKMFHLITDTLIVILILSNCVEWSQGQMFIDDIYYNGNVETIINSTDPFNVESLCIYFPNAIVGSQGPGKSDGHLNDGNYAQTIATLFETKGFPKGSIILKTYTQTSDFINSVEMTCSYNIVIIPDSPNDSESIEQIAEWILNVWRCDDMNLEIYTYEQIGINNLWAAFGSDCDISVCPLDTTSNGIGCSPASTETYEVVSNDTQLALINVVDNVRHRIQMNTAQCKLKNCIKGEARLNTALIRISTSSSFDNSLSPLNNGQTTRSFKINAKKWWTIFYTIIDYINTIVQAMTPRHRAIYPEGWMLRYA
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER. cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: ENGB_HELHP
Sequence: MVQVIESRFMSSASHLDNAPPPNASEIVFLGRSNVGKSTLINTLLNKPLAKSSSTPGKTQLINFFASVWVWHNQRLPLTFIDLPGFGYAKVSKTIKKEWERHLLNFLFMRQSIKLFLHLVDARHTDLAIDTSVATMLEQICRGDQCILRIYTKADKLNQSALNALYKRVYIQKNKVQGVDTDDTHTQSLLFSAISKNHRKMVSLTHLREEIVKYTLGLENGI
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RNPA_LACGA
Sequence: MRKSYRVKTERDFQKVFKEGQSMANRGFVVYTLPKEKQKHFRVGISVGKKVGHTAVARNRLKRFIRATLTELKPEIRSDLDFLVIARPYARDFDMERTKKNLIHVLRLAKVLSNEETETEEK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: TOM70_MOUSE
Sequence: MAASKPIEAAMAAAAAPGSGNGVGGGGGTAGPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGHHDGSGDSLEMSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTANNSSQVQAAMKGFEEIIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL
What is the function of this protein?
Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).  Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (By similarity).  Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection (PubMed:20628368).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, Translocase of outer mitochondrial membrane protein 70.
What is the protein family that this protein belongs to?
Belongs to the Tom70 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: DCD_BURP0
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.