PharMolix/UniProtQA huggingface dataset:
Protein: PILQ_NEIMH
Sequence: MNTKLTKIISGLFVATAAFQTASAGNITDIKVSSLPNKQKIVKVSFDKEIVNPTGFVTSSPARIALDFEQTGISMDQQVLEYADPLLSKISAAQNSSRARLVLNLNKPGQYNTEVRGNKVWIFINESDDTVSAPARPAVKAAPAAPAKQQAAAPSTKSAVSVSEPFTPAKQQAAAPFTESVVSVSAPFSPAKQQAAASAKQQAAAPAKQQAAAPAKQQAAAPAKQQAAAPAKQTNIDFRKDGKNAGIIELAALGFAGQPDISQQHDHIIVTLKNHTLPTTLQRSLDVADFKTPVQKVTLKRLNNDTQLIITTAGNWELVNKSAAPGYFTFQVLPKKQNLESGGVNNAPKTFTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVNGKMTLSLKDVPWDQALDLVMQARNLDMRQQGNIVNIAPRDELLAKDKALLQAEKDIADLGALYSQNFQLKYKNVEEFRSILRLDNADTTGNRNTLISGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQVMIEARIVEAADGFSRDLGVKFGATGKKKLKNDTSAFGWGVNSGFGGDDKWGAETKINLPITAAANSISLVRAISSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTSIANGGSSTNTELKKAVLGLTVTPNITPDGQIIMTVKINKDSPAQCASGNQTILCISTKNLNTQAMVENGGTLIVGGIYEEDNGNTLTKVPLLGDIPVIGNLFKTRGKKTDRRELLIFITPRIMGTAGNSLRY
What is the function of this protein?
Required for type IV pilus biogenesis and competence.  Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity).
What are the official names of this protein?
Type IV pilus biogenesis and competence protein PilQ.
What is the protein family that this protein belongs to?
Belongs to the bacterial secretin family. PilQ subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: ENO_DESAL
Sequence: MTQILEVTAREILDSRGNPTVEVDVYTESGAIGRAAVPSGASTGTREALELRDKKSKRYGGKGVAQAVKNVNEIIAPLIIGMDAADQAAVDLAMLDEDGTENKSKLGANAILGVSLATARAAADAFGFPLYRYLGGVAGQTLPLPMMNIINGGEHAANNLDIQEFMIIPKGAKTAAEAVRMGAEVFANLKAILKKGGHATAVGDEGGFAPDLDTNEEAFKCIMDAIKAAGYKAGKDIVLAIDAAASEFCVKGKYELKGEGKSLTTTQMIDYYEEMISKYPIVSIEDGLAEGDWDGWGEMTQRLGSIQLVGDDIFVTNPSIFRKGIEKGVGNSILVKLNQIGSLTETLQTIDLAKRYGYTTVISHRSGETEDTFISDLAVAVNAGQIKTGSLSRTDRVAKYNQLIRIEEDLGRAASFGTPFDKITDSKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RS16_META1
Sequence: MVKLRLKRVGKKFHAQYKIVAADARSPRDGKFIEELGHYDPHAKKLTLNKELLTKYLDQGAKPTDTVRTLLKQEQFYSNYIASKK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: TRER_ECOLI
Sequence: MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQLTRERVEAVMNQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLAVQTMLPAFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNIDGVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCATDTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYAEAGRQAACQLIAQVTGRSEPQQIIIPATLS
What is the function of this protein?
Repressor of the treBC operon.  It is able to bind trehalose-6-phosphate and trehalose.
What are the official names of this protein?
HTH-type transcriptional regulator TreR, Trehalose operon repressor.
Protein: HIS8_CHLPM
Sequence: MQRDIMRYLNPSLRDIAAYSVEGGQQAAIKLNQNESPFDLPMWLKDAIVSEFVREPWNRYPDILPYRGTKAYADFLGVPAEGVMMGNGSNELLYTIFLACLGPGRKILVPDPSFSLYEKLALLLQASLVRVPLKASLDFDVDAIIQSAQEESVDFVVLSSPNNPTGKSITFDDIRRIASSCDALVLVDEAYIEFSRQDSALPLIEEFPNLVVLRTMSKALALAGMRIGFAIGRPELIAEIAKPKIPFASSRLAEITLMHVLENYAIVTDAVSYILNARDELYGELLSVQGVEPFMSDTNFLVIRVPDADAVFRKLIGRGILVRNVSGYHLMKNCLRFNIGLPDENSRLLDALLAINGGMA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: GCVK_HHV6Z
Sequence: MDNGVETPQGQKTQPINLPPDRKRLRKHDGLGKGVKRKLFAEDSSPLKKQIPACSDMETLSSPVKFGCKSRSASALDESFGKCKHETACDCSAIEELLCHESLLDSPMKLSNAHTIFSSDKWKLELEKIIASKQIFLDMSENVELVAYGETLCNLRIFEKISSPFLFDVQSEERSYSVVYVPHNKELCGQFCQPEKTMARVLGVGAYGKVFDLDKVAIKTANEDESVISAFIAGVIRAKSGADLLSHDCVINNLLISNSVCMDHKVSLSRTYDVDLYKFEDWDVRNVMNYYSVFCKLADAVRFLNLKCRINHFDISPMNIFINHKKEIIFDAVLADYSLSEIHPEYNGTCAIAKEYDRNLQLVPISRNKFCDMFNPGFRPLVANAMILVNVCEAFDGENNPLRHCNLDLCAFAQVVLLCVLRMTDKRGCREAQLYYEKRLFALANEACRLNPLRYPFAYRDACCKVLAEHVVLLGLLFYRDVVDIYEKIYDFLDERGEFGLRDLFEATFLNNSKLTRRQPIRGGLASLQSSEYGEKLLHDLRALFLITSSADLDKDTSSLFQM
What is the function of this protein?
Phosphorylates the antiviral nucleoside analog ganciclovir.
What are the official names of this protein?
Probable ganciclovir kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. HCMV ganciclovir subfamily.
Protein: MYO7_ARATH
Sequence: MAASAKVTVGSHVWVEDPDDAWIDGEVEEVNSEEITVNCSGKTVVAKLNNVYPKDPEFPELGVDDMTKLAYLHEPGVLLNLKCRYNANEIYTYTGNILIAVNPFKRLPHLYGSETMKQYKGTAFGELSPHPFAVADSAYRKMINEGVSQAILVSGESGAGKTESTKMLMQYLAYMGGRAESEGRSVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPEQETERYKLGKPSTFRYLNQSNCYALDGLDDSKEYLATRKAMDVVGINSEEQDGIFRVVAAILHLGNIEFAKGEESEASEPKDEKSRFHLKVAAELFMCDGKALEDSLCKRVMVTRDESITKSLDPDSAALGRDALAKIVYSKLFDWLVTKINNSIGQDPNSKHIIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYTKEEIDWSYIEFIDNQDVLDLIEKKPGGIIALLDEACMFPRSTHDTFAQKLYQTFKNHKRFGKPKLAQTDFTICHYAGDVTYQTELFLDKNKDYVVGEHQALLSSSDCSFVSSLFPPLPEESSKTSKFSSIGSQFKQQLQSLLESLSTTEPHYIRCVKPNNLLKPDIFENINILHQLRCGGVMEAIRISCAGYPTRKPFNEFLTRFRILAPETTKSSYDEVDACKKLLAKVDLKGFQIGKTKVFLRAGQMAEMDAHRAEVLGHSARIIQRNVLTYQSRKKFLLLQAASTEIQALCRGQVARVWFETMRREAASLRIQKQARTYICQNAYKTLCSSACSIQTGMRAKAARIELQLRKKRRATIIIQSQIRRCLCHQRYVRTKKAAITTQCGWRVKVARRELRNLKMAAKETGALQDAKTKLENQVEELTSNLELEKQMRMEIEEAKSQEIEALQSVLTDIKLQLRDTQETKSKEISDLQSVLTDIKLQLRDTQETKSKEISDLQSALQDMQLEIEELSKGLEMTNDLAAENEQLKESVSSLQNKIDESERKYEEISKISEERIKDEVPVIDQSAIIKLETENQKLKALVSSMEEKIDELDRKHDETSPNITEKLKEDVSFDYEIVSNLEAENERLKALVGSLEKKINESGNNSTDEQEEGKYILKEESLTEDASIDNERVKKLADENKDLNDLVSSLEKKIDETEKKYEEASRLCEERLKQALDAETGLIDLKTSMQRLEEKVSDMETAEQIRRQQALVNSASRRMSPQVSFTGAPPLENGHQEPLAPIPSRRFGTESFRRSRIERQPHEFVDVLLKCVSKNIGFSHGKPVAALTIYKCLMRWKIFEAEKTSIFDRIVPVFGSAIENQEDDNHLAYWLTNTSTLLFLLQRSLRQQSSTGSSPTKPPQPTSFFGRMTQGFRSTSSPNLSTDVVQQVDARYPALLFKQQLTAYVETMYGIIRENVKREVSSLLSSCIQSLKESSCDSSVVNSPSKSSEENLPAKSSEENSPKKSSEENSPKESSGDKSPQKLSDDNSPSKEGQAVKSSEENSPASSWQSIIEFLNYILITWKKNYVPLFLVQKMFSQTFQYINVQLFNSLLLEREYCTVNMGIKVKAGLDELESWCSQATEEFVGSSWDELKHTRQAVVLLVTEPKSTITYDDLTINLCSVLSTEQLYRICTLCKDKDDGDHNVSPEVISNLKLLLTNEDENSRSFLLDDDSSIPFDTDEISSCMQEKDFANVKSASELADNPNFLFLKE
What is the function of this protein?
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation.  Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
What are the official names of this protein?
Myosin-7, Myosin XI A, AtXIA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class XI subfamily.
Protein: RLMH_YERPS
Sequence: MKLQLVAVGTKMPDWVQTGFIEYLRRFPKDMPFELAEIPAGKRGKNADIKRILEKEGELMLAAVGKNNRIVTLDIPGTPWETPQLAQQLERWKQDGRDVSLLIGGPEGLAPACKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4B_HUMAN
Sequence: MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE
What is the function of this protein?
Required for the binding of mRNA to ribosomes.  Functions in close association with EIF4-F and EIF4-A.  Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP.  Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
What are the official names of this protein?
Eukaryotic translation initiation factor 4B, eIF-4B.
Protein: ATP6_CHOCR
Sequence: MQTHFIITSPLEQFEIVTIFPFSISGLNFSLTNSSLFLIIAVFLLLFWTSLSFYSNTLIPNNWQLVKESIYEITASMVQDNLGSKGEFYFPFIFTLHLLLLYCNLIGMIPYSFTVTSHIVFTFGLALSIFIGINLIGIQTHGFKFFALFLPRGVPLAIVPLLITIEFLSYIVKVFTLSIRLFANMTSGHTLLKIIAGFAWTMLSAGGLLAIFHLIPLALLLALTGLELAIAGLQAYVFTLLTCIYLNDVLDMH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PUR7_STAAN
Sequence: MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: S35A3_HUMAN
Sequence: MFANLKYVSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQLDSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGELVSKNGFFQGYNRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPAGNPTKA
What is the function of this protein?
Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:10393322).  May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:23766508, PubMed:34981577).  However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (PubMed:32938718).
What are the official names of this protein?
UDP-N-acetylglucosamine transporter, Golgi UDP-GlcNAc transporter, Solute carrier family 35 member A3.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: IF6_SULIN
Sequence: MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGIFISGNDNGILLPKSTIDDEFRFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFNDIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLVHVDTSEKELKELEKLFSVKIDIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: ACKR1_SAIBB
Sequence: MGNCLHQAELSPSTENSSQLNLEDLWNFSYNGNDSFPEIDYDASLAAAAPCHSCSLLNDSSLPFFILASDLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPILAPGLGNTHSSALCSLGYCVWYGSAFAQALLLGCHASLGPKLGAGQVPGLTLGLPVGLWGATALLTLPITLASGASDGLCTPIYSTELEALQATHAVACFAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWVWFIFWWPHGLVLGLDFLVGSKLSLLPTCLAQQVLDLLLNLAEALAIVHCVATPLLLALFCHQTTRTLLPSLPLPERWSSPVDTLGSKS
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines.  Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC.  May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
What are the official names of this protein?
Atypical chemokine receptor 1, Duffy antigen/chemokine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: GCH1_ONCMY
Sequence: MERSKQSHDNQADSRPTTNESSLNGHFDGLVKKTPGMWDVKGRGTAGESSSHTGSSVVENWKHERTRSIEDNEMSLPSLAAAYTTIIRGLGKDPQRQGLLKTPWRAATAMQFFTKGYQEKIIDVLNDAILDEDHDEMVIVKDIDMFSMCEHHLVPIFGRVHIGYLPNKRVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRG
What is the function of this protein?
May positively regulate nitric oxide synthesis in endothelial cells.  May be involved in dopamine synthesis.  May modify pain sensitivity and persistence.
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ILVC_PSEFS
Sequence: MKVYYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVTDVASAVAAADLVMILTPDEFQSALYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYAAGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPSMTAKRRNNAAHGIEVIGEQLRSMMPWIGANKIVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MURD_COXB1
Sequence: MSSESLTVIVGLGKTGLSCAQFLAAKNQPFAVMDSREEPPEWENFIKTYPRVELIRGQFSEKLLNEAQEIILSPGVSLQEPLIAKQAAQGKSIIGDIELFARNVNKPIIAITGSNGKTTVTTVVGLMMKAAGRNVSVCGNIGEPVLEQITPEPDYYVLELSSFQLETTFSLRSQAATILNISEDHMNRYATLQDYLRAKQRIYTDCFIPIVNADEPEIWCHLPFNKKPLSFGLNNAADFSLAEHNQKTSIAYQGKILMPIQELKLNARHHLQNALAALALGTAAKIPIENMLHLLRDFSGIRHRCQWVRKYKEIDYYNDSKGTNVGATRAAIESLGQAAKGQLILIAGGQGKGADFSPLKDVVKRYVKQVILIGEDAPLLEKTLKEITVIKHADSMNEAVKRSTQAAKAGDIVLLSPACASFDMFTNYEHRGDVFTETVEAL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_RUBGI
Sequence: MSSGMDWLQVESLDLEAQGVAHRADGKVVFIEGALPGETVQVQVSRRKNQWEQGVLSALARESSQRVRPGCPHFGLHAGACGGCKMQHLHPAAQVAVKQRVLEDNLWHLGKVKPERLLRPIHGPAWGYRWRARLSVRYVPKKGVVLVGFHERKSRYVADMLECPVLPAKVSAMLPALRELIGAMEQRDRLPQIELAAGDEVIALVLRHLEPLSAGDAARLRAFGAEHGVQWWLQPKGPETVHRLDEGGPQLAYSLPEYGVTMPFKPTDFTQVNPQINRVLVDRAVRLLAPQPHERIVDWFCGLGNFTLPLARRAAAVHGIEGSETLVQRARENAAANGLAANTSFAARNLFEMSADELMTSGAADAWLVDPPREGAFALAKSLAELRGREGWTPPRRIVYVSCNPATLARDAGLIVHLAGFRCVAAGVVNMFPHTAHVESIAVFERSEAALSPRPVGEAAPELAAEPAPDAVA
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: CRCB_OLEA2
Sequence: MQKLLLIAIAGGLGSLSRYSLAGAVQRLFGASFPAGTFVVNITGCFLFGLVWGFLEDRLTLGPAARMIALTGFMGAFTTFSTFIFESVALLNSSQWLFAALNITGQIVLGILLLAAGLYLGKLV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSD_HISS2
Sequence: MYNAEKKQPTYWQRLKIAFQYVMPQLYLTLAAGWLAKQKWGSVTHFIIKLFAKKYHVNMQEAEKTEFKDYASFNEFFIRPLKSEARKIDENPTALCLPADGRISQCGHIEQQTLLQAKGHSFSLVDLLAGDTELAKEFEHGEFATIYLSPRDYHRVHMPCDATLRKMIYVPGDLFSVNPFLNEHIPNLLARNERVICVFDTEFGTMVQILVGATITASMSTVWAGIINPPRSTEVKEWTYSDESAVQLRKGQEMGAFQLGSTVINLFQADKVELANHLDVGVPVRVGEVLAYKK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LEU1_KLEP3
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQSIARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASIKLVCGDEIKTEAANGNGPVDAIYQAINRVTNYNIDLVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: TBB_ACHKL
Sequence: MRELVHIQGGQCGNQIGAKFWEVISDEHGVDPTGSYHGDSDLQLERINVYYNEATGTYVPRAILMDLEPGTMDSVRAGPYGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMCTYSVCPSPKVSDTVVEPYNATLSVHQLVENADEVMCLDNEALYDICFRTLKLTNPTYGDLNHLVCAAMSGITTLLRFPGQLNSVLKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQQFDAKNMMCAADPRHGRYLTAACMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGLKMSTTFIGNSTAIQEMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEDEEMDEMM
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HIS5_PYRAE
Sequence: MIVGVVDYTVGNIGSVLTALKRAGAVPVVVKGVEEAGRVDAVVLPGVGTYEAAYALARQFKEVVLEKPTLAICLGMQLLFESSEEGGGQGLGVFKGRVERIKARKVPNIGWRYTHVVKNSEIIAEGYYYYLHSYGVRWGENEAYTAYIKLEEKYVAAVERGHIIGVQFHPERSGRTGLELIKRFLAVAKR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_BUCA5
Sequence: MKIKKKYCGHVIIVGKANVGKSTLLNNIIGKKISIVSRKKNTTQSNITGIKTEDNYQSIYIDTPGVVFDKNNNQMKHHKNNFYQTTQIATLIIFMIDRIDWTIHDEIILNEIKKTKIPILIIINKIDKISNKIILLPFINFLKKKIDFIEILPISAKKISNLILLKNIIKSYLPENCHIYPECYVTTNSDFFTVSEIIREQLILFLGDELPSIIKVEIESFKKKEKIALYIKAIIWVKNVRQKSIVIGHNGEKIKKISMISRNNIEKKFYIKTHLVLWVKDKN
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.