PharMolix/UniProtQA huggingface dataset:
Protein: MUTH_ECOBW
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALVGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_DESPS
Sequence: MTIDYYETLSVERDADQGTIKKAYRKLAMKYHPDRNQGDKEAETLFKECTEAYEVLRDESKRRIYDTYGHEGLKNNGQRDTGGAGDIFSHFGDLFGFGGGGGRSQARRNGPIEGNDLRYDVSISFMESIQGVSKEVKLSRRETCWTCEGTGSRPGYQPQTCPTCNGRGQVLRSQGFFQVSTTCPECEGEGQVIKEPCNDCHGEGLVKKTKTVAIKIPAGVDTGARMRLRGEGEGGRRGGPSGDLFVIVHVSSHEFFERDGDTIYCRLPVSMTTAALGDTVDVPTVHGKKNLKIPAGSQSGERFTLRGEGVPSLRGRGNGDMVVELHVETPTGLCEEQKKMLRDFHSFCEEHGQHEKTKGFFAKLFDEVLGKNK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_STRA5
Sequence: MYVEMIDETGQVSEDIKKQTLDLLEFAAQKTGKENKEMAVTFVTNERSHELNLEYRDTDRPTDVISLEYKPEVDISFDEEDLAENPELAEMLEDFDSYIGELFISIDKAKEQAEEYGHSYEREMGFLAVHGFLHINGYDHYTPEEEKEMFSLQEEILTAYGLKRQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_BURA4
Sequence: MTQVQTAAVQPDAIPVAAPAPQRWRVADVVALFELPFNDLMFRAQQVHREHFDANAVQLSTLLSIKTGGCEEDCGYCSQSSHHDTGLKAEKLMDVDAVLDAARAAKANGASRFCMGAAWRNPKERHMPALTEMVRGVKELGLETCMTLGMLEDEQAQELANAGLDYYNHNLDTSPEFYGQVISTRTYQDRLDTLDRVRDAGINVCCGGIIGMGESRRERAGLISQLANLNPYPESVPINNLVAIEGTPLEGTAPLDPFEFVRTIAVARITMPKAVVRLSAGREQLDDAMQAMCFLAGANSMFYGDQLLTTSNPQTQRDRALFERLGIRASDADAMQANA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RS17_BART1
Sequence: MPKRVLQGVVISDKSDKTVVVKVERRYSHPLLKKTVRQSKNYKAHDENNQFKIGDQVSIQESRPISKDKCWIVVKDNVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: IF3_BACCR
Sequence: MMINEQIRAREVRLVGANGDQLGIKSRNDALDLAANLNLDLVLVAPNAKPPVCRIMDYGKFRFEQQKKEKEQRKNQKVISMKEVRLSPTIDEHDFNTKLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVSTVESKPKMEGRSMFLVLAPKNDK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_BACMK
Sequence: MKQIFIGIIRFYQKFISPMTPPTCRFYPTCSHYGLEAFQKHGTFKGFWLTCKRILKCHPFHPGGFDPVPDKKDDKVNS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THIG_PSEMY
Sequence: MSQVRSDKPFTLAGRTYQSRLLVGTGKYKDMDETRDAIAASGAEIVTVAVRRTNIGQNPGEPNLLDVISPEQYTILPNTAGCYDAAEAVRTCRLARELLDGHKLVKLEVLADQKTLFPNVIETIKAAEILVKDGFDVMVYTSDDPIIARQLAEIGCIAVMPLAGLIGSGLGICNPYNLRIILEEAKVPVLVDAGVGTASDATIAMELGCEAVLLNSAIAHAQDPILMARAMKHAVEAGRLAYLAGRMPKKLYASASSPLDGLIK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_SHEPA
Sequence: MPVTMSRAFLDNFLGNSPKWFKIAIISFLVINPIVFYFNPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMTSPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKIYVSLLFCISSAFLSAFLDALTVIAVIITVAVGFYSIYHKVASGKTFGESHDHTSDGYPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFAIRMSPVTVPVFFAGITTCFLVEKFKVFGYGQQLPDAVHKILSDYDAHEDANRTKHDKVKLLIQAVIGVWLIAGLALHLASVGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDQQLFAPVIQWALSYEGNTQLVIFYIANGLLSMVSDNVFVGTVYINEVKSALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMALPYTIVLSIVGVLAIQLGALEQMTQYFYDSQMLIHHSAQAAADGVVSSH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WDR18_XENLA
Sequence: MAAPLELVLSADAAGQVANCTVWEPVTGSVLLTYRGGNTSHRGLAVLGGQYLLGGQLGKNYINVWELQRRDQLQQKIVCPGPVNCLSASPNGLYLVAGIAESIYLWEVSTGHLLAILNSHYQDVTCLTFTDDSSHIISGAKDSLVLVWGLYSVLQVETSRGPEPRYVWSRHSLPITDVQCGIGGPQARVATSSLDQTIKLWDICSGDLLVSVLFDVRITSVAFDPAEYHLFCGGSDGVIYQVDLYTTPEQRERPFHPEQEMVFKGHRNQVTCLSVSLDGSMLISGSHDETVCVWDIQSKQSLRSVPHRGPVTNVFIIAAPSNMLRAESKPSFPLPHFSKHLQGAEGCEGPESGGVILRLGKQQGSKENTYLQRADQLQSLLGESEGKNLSGLVEQLRSRTSELEEELNVVRKINKDLFDFSARIITKQ
What is the function of this protein?
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.  Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).  May play a role during development (By similarity).
What are the official names of this protein?
WD repeat-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the WD repeat IPI3/WDR18 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Dynein axonemal particle. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Protein: CL162_CAEEL
Sequence: MNIFTLLFIYFLSDTVAAYCYYGTEYKNATGCFQFFRTPLNFTNAVRFCRVNMKSTLVRPTSSIRNQQIRGAALKLGIEEYWIGASNVDNDWEWLDGSMLTYSNFDVGGGYPKKTESQIGAVSMSSLAGLWYTKLDAMFLPFVCEFPPSTVYDNGILYRSPKTQSLIFPSAGTKAALLMVDAVDQSRLYSKNEIGPLKTEAETGEKVYLKPINISTNGFPEFSGPPIVILNPYKRKIKVKPVMVSQTETEMSRSRKEKEETEDSINVKSLKEGGTARGNGSSVAEELNSNSKEKREREENETIRSKTIQISRG
What are the official names of this protein?
C-type lectin domain-containing protein 162.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_MESVI
Sequence: MSFQVRIIAPNGIIWDSEAEEIILSTNTGKIGVLTNHTSLLTGLDIGTIRIRALNNQWNTLALMSGFAVIKDNVATIIVSEAENGANIKSEEAQTQLEEAKSYFNTAKGTKNEVEANLAVKRAETRLKASQNL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ATPF_LACH4
Sequence: MTIQTLFAASHHIYLGNALWYLICFAILLLLIKHFAWGPVSDMMEKRRQKVINDLDSAASDRKKAETLANEREAALKNSRQEATQILSDAKANAQKTGKEIVASANEDAAAIRKKANEEAAKAKSDALDSARDQVADISLAIAEKVIAKNLSAEDQKDLVDQFIKELDD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: BGL11_ORYSJ
Sequence: MAVAGAMVMSGALLLLHLLAFTCVACNGGSELPPISRRSFPKGFIFGTSSSSYQFEGGAVLGGRGPSIWDTFTHQSPDKITDRSNGDVACDSYHLYKEDVRSMKEMGMDAYRFSISWSRILPSALSGGVNREGISYYNNLINELLSKGVQPFVTLFHWDSPQALEDKYKGFLSPNIINDYKEYAETCFKEFGDRVKHWITFNEPWTFCSMGYASGIMAPGRCSSWEVGKCRVGDSGREPYTACHHQLLAHAETVRLYKEKYQALQKGKIGIILNADWFVPLSQSKSSSDAARRALDFMLGWFMDPLIRGDYPLSMRELVGNRLPEFSKEQSGMVKGAFDFIGLNYYTSSYADNDPPSHGHNNSYNTDAHAKITGSRNGIPIGPQAASFWFHIYPEGICEMLLYVKENYGNPTIYITENGVDEVNNKTMPLEEALKDDTRIEYYHKHLLALLSAMRDGANVKGYFAWSLLDNFEWAEGYTVRFGINFVDYDDGMKRYPKNSARWFKKFLQKSNRDGNKRLKRVAYNAFSN
What are the official names of this protein?
Beta-glucosidase 11, Os4bglu11.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: SSRP_HYDCU
Sequence: MAKKKKQNNPNSIAQNKKARFDYFIEETFEAGLALEGWEVKSLRQGKVQINESYILLKNNEAWLFGALITPLITASTHSNHDPLRLRKLLMHRREIDRLMGLVDQKGFTVVPLGLHWSKGKVKISIGLAKGKKLHDKRATQKERDWNRDKQRIMKYHA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MOBA_STAAM
Sequence: MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNIYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KMO_STRMK
Sequence: MIAHASRSLSIIGAGLAGSLLAILLSRQGWRITLYERRGDPRVADYESGRSINLALAERGRNALRQAGVEDEVMARAVMMRGRMVHPREGEPQLQRYGRDDSEVIWSIHRSDLNTTLLELAEQAGATVHFHRRLHTVDFDAGYARFIDDRDDSPHDIRFDTLIGADGAGSALRAAMNRRAPLGEDIAFLDHSYKELEIPPADDGSFRIERNALHIWPRGHYMCIALPNHEGTFTVTLFLPNQGDPSFATINTGAQAEALFAREFADTLPLIPNLRADWEQHPPGLLGTLTLDRWHQQGRAVLIGDAAHAMVPFHGQGMNCAFEDCVALARHLMEADDLEGAFAAFEAERKPNARAIQQMALENYLEMRDRVADPAFLLQRELEQELQRRWPTRFVPHYTMVTFLHTPYAEALRRTELQRDMLVAATTGHDSLDNIDWAALEAQIHAQLPVLEGAH
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: NADK_MYCLB
Sequence: MTPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNMRAMGVDIEVVDADPHVAQGCELVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEAEAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGWALNEASLEKGPRLGVLGVVVEIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSKFRLPVTGWRGK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_MYCTU
Sequence: MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYPRAAFEQLARRASKAPRSNPEARAFLRNLAAGTDEQHPDSQGRITLSADHRRYASLSKDCVVIGAVDYLEIWDAQAWQNYQQIHEENFSAASDEALGDIF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NKG2A_HUMAN
Sequence: MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL
What is the function of this protein?
(Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32203188, PubMed:32859121).  On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121).
What are the official names of this protein?
NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: SYFB_LEPBA
Sequence: MKLSVDWLNEFTPLSQIPFEKVLEKINTSICEIDDVEEFKSHLSSVITVKIKSLEKHPNAEKLQTTIATDGSKEYQIVTAATNVAVGDIVPLALPGTKLDGKEILDSELRGVRSQGMYCSEKELGMALESSGVLILPKDTTLGISVRKYFLWEDTILTIDNKSITHRPDLWNHFGFARELASQLQIPLHHFPLQADTKWESGNQGLTVEKSEHAHAYYVCSIQNVNITESIPKIKSRLEKCGIRSINNVVDVSNYLLLELGQPTHFFDRSKLQSTSFTVSKSKEGESISLLDDTSPTLPNHILLIQNGETPVALAGVMGGKDSAVSESTKEIVMESAVFKREDVRYTIRKTNIRTESAVRYEKGLDSYTCLPVMKRAVQLLKENGNPNVKVFEPQGFNHTESKTVTIETNLSFLRHKLGKKISLHEVTDILQRLGFEVTTKDESLSVLVPKYRQNYDVTIPEDLVEEIGRTIGYASIRTEALSMAVETPIRNPLRELERRVKQFLALEVGFNEVYNYSFASPTDAKLEKEFEVTSLKIANEMPEEHSLLRNSLYPGLIKQTKVNQDRFEKVNLFELGRTYHKEGNDATLAQEKRWISLLSLSKCKPTDLSSIEDEFLTVRETISELFLFLNLPKFEWVKLPRTHFHPNASLVLLYDGKEVVELGILHTRFADLYDLKRRAILSKIDMEVLVQIWETYGRNSHFVPPSHFPQGQLDLSLIMNESDPTESFANLVKTLRIPELESVFVQTIFQGESVGEGKKSVTYRFILMSYDKTFTQDRFKELSDRLVETAKSNGYSLR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H32_TETHY
Sequence: MARTKQTARKSTGAKAPRKQLASKAARKSAPATGGIKKPHR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DNAK_SALPB
Sequence: MGKIIGIDLGTTNSCVAIMDGTQARVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPYKIIGADNGDAWLDVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEVGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDTRLINYLVDEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDINDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTPLITKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEEEIQKMVRDAEANAESDRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALNALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQAGSADASANNAKDDDVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NANE_ECO5E
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLTLVKRLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: CMOI_BACSU
Sequence: MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLRDILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR
What is the function of this protein?
Involved in a cysteine salvage pathway from S-alkylcysteine.  Catalyzes the reduction of N-acetyl-S-hydroxy-L-cysteine (N-acetyl-L-cysteine sulfenic acid) to N-acetyl-L-cysteine.  This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles.
What are the official names of this protein?
N-acetyl-S-hydroxy-L-cysteine reductase, N-acetyl-L-cysteine sulfenic acid reductase.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: RLME_HALMA
Sequence: MSGKDDYYNRAKQEGYRARSAYKLQQLDDTAGLLGEGRTVVDLGAAPGGWMQVAAERIGERGTLVGVDRQTIDDLEDPEPTVEYVRGDMTEDSTKDEIREIVGESDGSGGPVDVVISDMAPNMTGQYDLDHARSVHLVRQAFEVATDLLDAGGDFCAKVFDGQDLDDLIADIEPEFEYVREVRPDASRDSSSELYLVAKHRLTGPVREGDIVEATIEDIGEEGDGIAKVENFTVFVSGVEDGETVEVRIDDVKPRYAFAEPVE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_GEOTN
Sequence: MSSIRLYNTLTRKKETFEPLEPNKVKMYVCGPTVYNYIHIGNARAAIVFDTIRRYLEFRGYDVTYVSNFTDVDDKLIRAARELGESVPAIAERFIEAYFEDIEALGCKKADIHPRVTENIETIIEFIQALIDKGYAYEVDGDVYYRTRKFDGYGKLSHQSIDELQAGARIEVGEKKDDPLDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMARKYLGDTIDIHAGGQDLTFPHHENEIAQSEALTGKPFAKYWLHNGYLNINNEKMSKSLGNFVLVHDIIRQIDPQVLRFFMLSVHYRHPINYSEELLESARRGLERLRTAYGNLQHRLGASTNLTDNDGEWLSRLADIRASFIREMDDDFNTANGIAVLFELAKQANLYLQEKTTSENVIHAFLREFEQLMDVLGLTLKQEELLDEEIEALIRQRNEARKNRDFALADRIRDELKAKNIILEDTPQGTRWKRGS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_STRA1
Sequence: MANKKIRIRLKAYEHRTLDTAAEKIVETATRTGATVAGPVPLPTERSLYTIIRATHKYKDSREQFEMRTHKRLVDIINPTQKTVDALMKLDLPSGVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: NCAP_I81A3
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEVEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDSFRMLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIKMMENARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.