PharMolix/UniProtQA huggingface dataset:
Protein: SSUB1_AGRFC
Sequence: MSTGNVTTLRRPEAPPSLPAGTEAKIEHHARPAEGKVAFSFRNVTKSFGDKPVLRGIDLDVREGEFLAVIGKSGCGKSTLLRILAGLDTPTTGTVSKDPSNRTRMMFQEPRLLPWERIANNVSVGLTGIAKGEAAREQALGILDEVGLKDRAGEWPYVLSGGQKQRVALARALVAHPQILALDEPLGALDALTRIEMQLLLERIWRKQKFTAVLVTHDVSEAVALADRIVVIDEGRIALDLDVKLPRPRRHGTPEFARLEEQVLNQLFGRGDITGQ
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: THTPA_HUMAN
Sequence: MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG
What is the function of this protein?
Hydrolase highly specific for thiamine triphosphate (ThTP).
What are the official names of this protein?
Thiamine-triphosphatase, ThTPase.
What is the protein family that this protein belongs to?
Belongs to the ThTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1E_MIMIV
Sequence: MSYDEKHLMEGIYREKSGDKFIYYYFDNNEEVTTKDIERINKLRIPPAWTNVWVARDPNSPIQAIGTDSKGRKQYRYNEIHIQGAEKEKFKRLYDFIKSIPKLEKAMVRDNNFPFYNKNRVISLMLQMVRDYNMRVGKEVYARQNKSYGISSLRKKHVKISPGVITLNFKGKSGQRLNYTIRNDFYIDGIKMLMKLEGDRLFQYISTDEDGNEKIMRVNDRDLNKYIQENMGSEFTIKDFRTFGANLYFIQALLSETRKRTPKNRKTIKKNIANAFKSTARQLKHTGAVSKKSYVMNYTLELYQNNPEFFIEHKNDDPIDFLLRILKSYRKDVLGE
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).  Cleaves DNA after CCCTT sequence.
What are the official names of this protein?
DNA topoisomerase 1B, TopIB, DNA topoisomerase type IB.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Virion.
Protein: IGHM_CHICK
Sequence: ASASPSPPRLFPLVLCSPSDSVYTVGCAAFDFQPSSIAFTWFDSNNSSVSGMDVIPKVISGPPYRAVSRIQMNQSEGKEKQPFRCRAAHPRGNVEVSVMNPGPIPTPNGIPLFVTMHPPSREDFEGPFRNASILCQTRGRRRPTEVTWYKNGSPVAAAATTATTVGPEVVAESRISVTESEWDTGATFSCVVEGEMRNTSKRMECGLEPVVQQDIAIRVITPSFVDIFISKSATLTCRVSNMVNADGLEVSWWKEKGGKLETALGKRVLQSNGLYTVDGVATVCASEWDGGDGYVCKVNHPDLLFPMEEKMRKTKASNARPPSVYVFPPPTEQLNGNQRLSVTCMAQGFNPPHLFVRWMRNGEPLPQSQSVTSAPMAENPENESYVAYSVLGVGAEEWGAGNVYTCLVGHEALPLQLAQKSVDRASGKASAVNVSLVLADSAAACY
What are the official names of this protein?
Ig mu chain C region.
Protein: RSMH_MYCPU
Sequence: MQLHKPVLLKDVIENLEINPEGIYVDLTLGYAGHSSEILKKLSSKGKLIGFDQDSFAIEKSRQRLSQISDNFVLINDNFVNFKVYLDKMNISFVDGFLLDLGVSSVQLDFAHRGFSYSKLGPLDMRMNLDQPLKADDIVNGYDQESLCKIFIENADVKLAKQVAKGIVNNRPIKDTLELVEVIRSSLPAALVRKKNPAKAVFQAIRIAVNDELIVLKKFLAQSLDFLKKDSKMLIITFHSIEDRIVKDFFKRQVKNKHDRRLPIMEQKDYQVKTIKPTEEEIAQNRRAKSSKLRIIKKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_SOLM1
Sequence: MAQLTKNFGKIVKTLTIPHLLNLQIDSYELFLQKDIPPTSREDAGLEGVFRSVFPIEDFNRTASLEYVSYEIGEPKYDVPECIAKGLTFEAPLRIKVRLVVYDVDEETENRTIRDIKEQIIYFGTVPLMTEKGTFIINGTERVIVNQLQRSPGIIFEHDSGKSHTSRKVLYSCRIIPMRGSWLDFDYDHKDILYVRIDRRRKMPATILFKAMGMSRADILRYFYEVEHFTFEPHHVFRQVLPDFYRKEKAYSEIRDSEGKVIVAVDKPITKRAWRLMLEAGIEKVEVDPATLLGLFLAEDLADPATGEVMAEAGDELNADLIEKLKDAGIVELSLLHTRGVDTSSSIRDTLALDKTIDTITAQVEIYRRLRPSSPPTPEIAANFFENLFRNPDYYDLSPVGRYKINARLKVDQPLDFRTLANDDILKAVKHLTFLKDSHGPADDIDHLGNRRVRPVGELVENQYRIGLVRMERAIKERMSLQEVATLMPHDLINPKPVAAVLKEFFGTSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHTSHYGRICPIETPEGPNIGLIVSLTTHSKVNDFGFIETPYKVVKDGQLTGETIYLDATREIDEVIAGANAPLDENKAFINSMVGARIRGDQVVIPREQVTLMDISPSQIVSVSAALIPFLEHDDANRALMGSNMQRQAVPLLRCEQPLVGTGMEGAVAKDSGSCILAEGEGFVHYADAERIIVCYDDPAVGTDTGSAKTYELLKHHKSNQNTCFGQVPRVLVGQRVVKGDVLADGPGIRDGELALGKNLLVAFMPWCGYNYEDSILISENAVKDDTFTSVHIEEFEVVARDTKLGPEEITRDIPNVGEEMLKDLDDCGIIRIGARVAPDDILVGKITPKGETQLTPEEKLLRAIFGDKARDVKNTSLKVPPGIEGTVIDVRVFNRRSGEKDDRTRQIEDFELARLDTKEGQHAAAIAANVRRRLWPVVSGKTVFQTIKGVKKGEVLLEANHPMTQEVLEALPVKKLSGLFTSKETNEAVAEVLDEYDRHIQFIKGLYDQKREKTTEGDDLPPGVIKMVKVYVAVKRKLNVGDKMAGRHGNKGVVSCILPIEDMPFFSHGRPVDIVLNPLGVPSRMNIGQILETHLGWAGMELGRQLAEMVDSGKAMEGVRDRAKAVFDTEETTALIDGMSDDDLRDALRALKNGIVAKTPVFDGATEDELWSWLKLAGLPEDGKVTLYDGRTGEAFHRPVTVGCMYILKLHHLVDEKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGASYLLQEFLTVKSDDVGGRVKMYEKIVKGDNFLEAGLPESFNVLVKELMSLGLDVDLIQDEKKIAKAPPRR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: YAFD_ECOLI
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPPGEPLSTEERIRILVWNIYKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVVNIHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRRRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVSEASVLVTRASDHNPLLVEFSPGKPDK
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2B_PYRHO
Sequence: MEIDYYDYEKLLEKAYEELPENVKHHKSRFEVPGALVTIEGNKTIIENFKDIAEALNRDPQHLLKFLLREIATAGTLEGKRVVLQGRFTPYLIANKLKKYIKEYVICPVCGSPDTKIIKRDRFYFLKCEACGAETPIQHL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: CYCM_CLITE
Sequence: MAYVRLTSLAVLFFLAASVMKTEGGLPTCGETCTLGTCYVPDCSCSWPICMKNHIIAANAKTVNEHRLLCTSHEDCFKKGTGNYCASFPDSNIHFGWCFHAESEGYLLKDFMNMSKDDLKMPLESTN
What is the function of this protein?
Probably participates in a plant defense mechanism.  Displays insecticidal activity against H. armigera.  Has weak hemolytic activity.  Binds to phospholipid membranes.
What are the official names of this protein?
Cyclotide cter-M.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: LPXC_NEIMA
Sequence: MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLINDTRLSSTIVTDKGVRVGTIEHIMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAGVVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTIEFDHPVFNRSSPTFEIDFAGKSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHKILDAIGDLYIVGHPIIGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHELNIRTCG
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: NHAP_APHHA
Sequence: MTIEAAMGEEAIKENLEQFLIVLSVSLGVATLSQISSFFRQIPYTLLLVIVGLGLAFVDIRLVNLSPELILEIFLPPLLFEAAWNIRWRNLKKNLFPVVLLAIIGVVISVVGIGFSLNYFSGLSLPIALLVGAILAATDPVSVIALFRELGVGERLTVLMEGESLFNDGVAVVAFSLLVGIPLGTQEFSVTNTLIQFVTLQGIGIGCGGVIGFGISYLTQRFDLPLVEQSLTLVSAYGTYLITEELGGSGVIGVVTVGLILGNFGSRIGMNPRTRLLVSEFWEFIAFFVNSIVFLLIGDQINIRGLADNGQLILITIIALVIIRAISIYGLGTISNLITKQDISWQEETVLWWGGLRGSVSIALALSVPVMLDGRQDIIEAVFGVVLFTLLVQGLTMQTVIEKLGLIGDRAQRRTYSELIARRSALERVLAHLNAVPPSPSIRMKSLKTTKEASKGQLESRQTKKLRSYNNSYPQLRSLEQEQLRELTFKVEADTYAELIRAGKLNNNLSPLLQEVLAKPE
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.  Shows also high Ca(2+)/H(+) antiporter activity at alkaline pH.  Does not catalyze exchange between Li(+) and H(+).
What are the official names of this protein?
Na(+)/H(+) antiporter ApNhaP, Sodium/proton antiporter ApNhaP.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PARD3_CAUVC
Sequence: MNKPAKPAADDVDDLFGRPLTPAEEDTWFEHNREAIGQLVDEAWAEFERGEYDERSFAEIIAQGVAEHNAKR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the effect of cognate toxin ParE3, but no other RelE or ParE toxin.
What are the official names of this protein?
Antitoxin ParD3.
Protein: PER4_BETPN
Sequence: FYDTTCPK
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 4.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISDE_STAA3
Sequence: MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme.  Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).
What are the official names of this protein?
High-affinity heme uptake system protein IsdE, Iron-regulated surface determinant protein E, Staphylococcal iron-regulated protein F.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RS8_SHEPW
Sequence: MSMQDPIADMLTRIRNGQAAKHVSVKMPSAKLKIAIAKVLKEEGYITDYAVADEAKPELEVTLKYFQGQPVVETIQRVSRPGLRIYKGKNELPKVMGGLGVAIVSTSKGLMTDRTARQNGMGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SRPC_PSEPU
Sequence: MKFKSLPMFALLMLGGCSLIPDYQQPAAPMQAQWPTGQAYGGQGDQRSIATALPKAKEFFKDPALVRLLDAALENNRDLRIAAKNVESYRALYRIQRAERFPTLDGQASGNRTRLPDDLSPTGDSRIDSQYQVGLVTAYELDLFGRIRSLSNQALEKYLATEEAQRSVQIALIGDVATTYFLWRTDQALLELTEATLTSYVESLAMIESSAWAGTSSELDVRQARTLVNQAQAQQALYTRRIAQDVNALELLLGSKIPTDLPKNSPLAMSALGKVPAGLPADLLLNRPDIRSAEHQLMAANANIGAARAAFFPRISLTASAGSASSDLDGLFNSGSDSWSFAPQISVPIFNAGKLRANLDYAELQKDVGVATYEKSIQTAFREVADGLAARGTYGKQLSAQSELVDNYKAYFSLAQQRYDQGVDSYLTVLDAQRELFSSQQKLLNDQLDQINSEVQLYKALGGGWSVSQN
What is the function of this protein?
The outer membrane component of an organic solvent efflux pump.  Involved in export of a number of low log POW compounds including hexane (log POW 3. 5), toluene (log POW 2. 5) and dimethylphthalate (log POW 2. 3).  The solvent resistance phenotype has been postulated to depend on the operon expression level.
What are the official names of this protein?
Solvent efflux pump outer membrane protein SrpC.
What is the protein family that this protein belongs to?
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RL24_BRUMB
Sequence: MQKIRKGDSVVVLSGKDKGRKGEVLKVMPKDEQALVSGINIVKRHQRQTQTQEAGIISKEAPIHLSNLAIADPKDGKPTRVGFRVEDGKKVRVAKRSGALIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PSUG_GLAP5
Sequence: MNNYLILSDEVQRGMAQGLPIVALESTIISHGMPYPQNVAMAREVEQIIRDNGAVPATIAIIDGKIRIGLSDDELELFGSSKGIAKVSRRDLPQIIASKKLGATTVASTMICAHLAGIKFFVTGGLGGVHKGWETTLDISADLDELAQTSVTVICAGAKSILDLDATLEYLETKGVPVVGYKTKNLPAFFTRDSGLPLALSCEELTEIAEMIKVKWQLGLEGGVVVANPIPQEDELAPSYINGIIDTAVKEAEEKGIIGKDITPFLLGKIVEMTEGKSLEANIKLVKNNAKVGARLAVEFFK
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: YDYA_SCHPO
Sequence: MMLPSYLHFAIRKKVLAIFIVLLIISAYLGFAPALPVPINDKVCHFFVFFLLTLVFYWVFDLSRRRATQLTILVCGVFGGLGSEFVQSFLTYRTFDLFDIVANLLGCSLALLLNILYHKRRLEKIRLQRYGHVPTIADDLEMQASAAEEEEEGEEDVSKSTP
What are the official names of this protein?
Uncharacterized protein C11E3.10.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NRDR_SINMW
Sequence: MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVPFDRDKLLRSFEIALRKRPVDRDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TRPA_STRPJ
Sequence: MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGIERQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DRE2_PLAVS
Sequence: MMNFADTLVILNDDAPCELLRKKYAEMLVPTVSVSSFKRNKIYKTYNNVFLYTYREFDFLWDLDDNILHKVQRCLNKSGVLKLVLYISNTAGGDSQRHDEIAKRLKKECLYSGFINISNETNMAENGIIINVTAENPDFLSNEDDNDEHSSDGEAHENAEDNKKVVNRVCANCTCGKKANGVKLDTVAINEKEVQYLTENAVSSCGNCYLGDAFRCASCPYKGLPAFQPGENVKLNLDNEPN
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: PGK_PHOPR
Sequence: MRGRTMSVIKMTDLELAGKRVFIRADLNVPVKDGKVTSDARILASLPTIKRCLEAGAKVMVTSHLGRPTEGEYNEEFSLAPVVNYLNDALDCDVKLAKDYLDGIELNAGELVVLENVRFNKGEKKNDEALSKKYAALCDIFVMDAFGTAHRAQASTHGVGMNAAIACAGPLLANELEALGKAMDNPARPLVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAEGHNVGKSLYEADLVETAKKLMKDCAIPVATDVACAKAFDENAEAVIKHVSEVQDDDMIFDLGPDSTAVLAEIISNAKTILWNGPVGVFEFKNFEAGTAGIAKAIADSEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVAMLEERAKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_FRACI
Sequence: MTYFVLFLSLCFVLGGLAVASNPSPYYGVVGLVLASVVGCGWLLSLGVSFVSLVLFMVYLGGMLVVFVYSVALAADPFPEAWGDWRVVGYGVSFVGVLVMGLVIGGFIGCLNFGVVTVDSVGMFSVRLDFSGVAMFYSCGVGMFLVAGWGLLLTLFVVLELVRGLSRGAIRAV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: SPT6_SCHPO
Sequence: MSENEVVGSPTTNGDKNEDGYPAENGEGTNVDDNNNEEEKDGIPLDNDNDENDSSEESATDEEAERQVREGFIVEDEEDEVPQEIRRKKKRKKHAESTADQDMLDEEDLELVMENTGQGSRFSKLRRLKRGRDQEETLENIFSEEEEEEENEVDDEAPNRTQGHRAGVIDEFADFIEQDEFEDEERQEEKYETGPPIESVRPEALGISDDDYIQIYEVFGDGTDYAFALEDEDAEDELEESVSLKTIFEPSELKDKMLTEEDEIIRITDEPERMQLYMKRNIDCSEDEFREQVAWIIDYLLKNRRDIDAELYEPFQTAVRYVVHFFIRDSLEVPFIWQHRRDYIVHNNRERNTITPLLSQNDLWNIFFLCTKFWSLHSKKQDILKLYSDLGINDDLVVPFCEAASSLDAIDDLNDYIHFTYSEQIRDRALLMGTGLRRPQGSKYSFFEKFRKSSLYNLVKEFGMSAKDFSFNVAQGARLRFVEDNTLSPEELSRTYVTNELSSPEQVLQKARRVLAEEIIHDPQFRKSFRDKLYNAGVVTVLATQKGVRKIGSEHPYYEFKYLKRKPLGSFELEPILFLKMLKAEEEGLIQLSIEFEDPDDVFKGLLELFVSDNFSENAMQWNAQRELVLKEVFKRFSALAPDAIRETLRSRYLDELGMRCRNQLFSRLDQAPYEPSTKNFDRGTIPSVLAVSNGKGESSDAIICVFVDDVGEPTDSLKLADLRDLANQAMFAEFVEKVKPDVIGVSGMSVSAHKIRQHVQDSLTSHEPVDLIMVNDEVARLYQNSTRAVDEFPTLPTISCYCVALARYVQNPLFEYAAMGRDLMSLSFDPWQHLLPPDVLWKYLETALVDISSLVGIDINEAVTNKYEANILPYIAGLGPRKADYVLKKIAATGGRIDNRSDLISKQIMSRKVFINCSSFFIIPNDEYPNMDILDSTRIHNEDYELARKMASDALELDEEDIEELETNRGVVYHLLEENETGKLDELVLEEYADQLEREFHQKKRNTLEKIRLELKDPYGEQRNVFHKLTPSEIFLMLTGENPEELQADAIVPVNVRRVTNRFVAVKLDCGIDGNIKADEVSDDFIPPPQLLQVGQTVEGVIISLDEANFMVDLSLRNSVLQSANSKRQTSSHRTSYWDTEAEKRDTERMQAETQAEQRVARVIKHPLFKDLNASQAEAYLSKMQVGDLVIRPSSKGSDHIVVTWKVAEGSYQHIDVLELEKENEFTIGQKLLVKGRFEKMTYQYSDLDELIVLHIKAIAKKIDEMCIHDKFRKGTQAETEKWLESYSEANPKRSCYAFCFDHQHPGYFILCFKASVNSPVTAWPVKVIPNAFFLQGNVYGDMTALCNGFKLLYAARTKNFRRM
What is the function of this protein?
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters.  Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
What are the official names of this protein?
Transcription elongation factor spt6, Chromatin elongation factor spt6.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENV_HV193
Sequence: MRVRGMQRNWQHLGKWGLLFLGTLIICNAAENLWVTVYYGVPVWKEATTTLFCASDAKSYEKEAHNVWATHACVPTDPNPQEVVLENVTERFNMWENNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLDCRNIATNGTNDTIAINDTLKEDPEAIQNCSFNTTTEIRDKQLKVHALFYKLDIVQINKDDNRTYRLINCDASTITQACPKVSWDPIPIHYCAPAGYAILKCNEKNFTGTGSCKNVSTVQCTHGIKPVVSTQLLLNGSLAEGEIVIRSQNISDNAKTIIVHLNESVQINCTRPNNNTRKRISLGPGRVFYTTGEIIGDIRKAHCNVSGTQWRNTLAKVKAKLGSYFPNATIKFNSSSGGDLEITRHNFNCMGEFFYCNTDELFNDTKFNDTGFNGTITLPCRIKQIVNMWQEVGRAMYANPIAGNITCNSNITGLLLTRDGGLNSTNETFRPGGGNMKDNWRSELYKYKVVEIEPLGVAPTKAKRQVVKRERRAVGLGALFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGLWGCSGKLICTTNVPWNSSWSNKSLEEIWGNMTWMEWEKEVSNYSKEIYRLIEDSQNQQEKNEQELLALDKWASLWNWFDITQWLWYIKIFIMIVGGLIGLRIVFTVLSIVNRVRKGYSPLSFQTHIPSPREPDRPEGIEEGGGEQGKDRSVRLVTGFLALAWDDLRNLCLFSYRHLRDFILIAARIVDRGLKRGWEALKYLGNLTQYWGQELKNSAISLLNATAIAVAEWTDRVIEALQRAGRAILNIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.