PharMolix/UniProtQA huggingface dataset:
Protein: TX703_LYCSI
Sequence: MKLIIFTGLALLLIVSLIDVEAQNEGACLPRGSVCTTNHAGCCSKLGCDCYRRFEKGVEKGQKCWCIPTGLRYSKEKE
What are the official names of this protein?
U7-lycotoxin-Ls1d, Toxin-like structure LSTX-G3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 07 (U7-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_SHEB9
Sequence: MPRSLKKGPFIDLHLLKKVEKAMEAGDKKPIKTWSRRSMIIPNMIGLTIAVHNGRQHVPVFVTDEMIGHKLGEFSPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SODM_MYCSI
Sequence: AEYTLPDLGWDYAASGPG
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_AGRFC
Sequence: MTNSKQKLVLASGSPRRLELLHQIGIEPARLMPMDIDETPVKLEHPRTLCRRLSQQKAEAAQAALKSEQAWKDAYVLGSDTVVAVGRRIVGKAEYTEEASAALHLLSGRSHWVYTGICLVTPDGKIRQKVAETKVRFKRLSTREIDAYIASGQWRGKAGAYGIQGIAGAFVQKLTGSYTNVVGLPLYETMSLLSGEGFEVTSGWLEG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_HELPJ
Sequence: MQEIFLCSISNVRSGDCKEDCAYCTQSSHHQGAIKRYKFKDEKVVLQEARALRELGALGFCLVTSGRELDDEKCEYIAKLAKAINKEELGLHLIACCGRADLEQLEFLRDAGIHSYNHNLETSQNFFPKICTTHTWEERFITCENALRAGLGLCSGGIFGLNESWEDRIEMLRALASLSPHTTPINFFIKNPVLPIDAETLSADEALECVLLAKEFLPNARLMVAGGREVVFKDNDKQEAKLFEYGINAVVLGDYLTTKGKAPKKDIEKLLSYGLTMATSCH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: WNT3A_XENLA
Sequence: MGCFGYLLLIIGLHQVLATYPIWWSLAVGQQYSSLGTQPIPCGTIPGLVAKQMRFCRNYMEIMPSVAEGVKIGIQECQHQFRGRRWNCTTVNDNLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSATICGCDTHHKGPPGEGWKWGGCSEDMDFGSMVSREFADARENRPDARSAMNRHNNEAGRTSILDHRHLKCKCHGLSGSCEVKTCWWSQPDFRVIGDYLKDKYDSASEMVVEKHRESRGWVETLRPKYTFFKPPIERDLIYYESSPNFCEPNPETGSFGTRDRECNVTSHGIDGCDLLCCGRGQNTRTEKRKEKCHCIFHWCCYVSCQECMRVYDVHTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family.  Required for normal embryonic mesoderm development and formation of caudal somites.  Required for normal morphogenesis of the developing neural tube.
What are the official names of this protein?
Protein Wnt-3a, XWnt-3a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: RNH2_BACLD
Sequence: MKTLTVKEIKEHLQSVSDEKDPFIEQCKNDERKSVQALVDAWLKKNERLSAMREEWQAMTSFERSLRARGYQYIAGIDEAGRGPLAGPVVAAAVILKEDCEILGLTDSKKLSKQKREDYYSYIMEEAAAVGVGIADAHEIDELNIYEASKAAMLKAVQALDVAPDYLLIDAMSLAVDTEQSSIIKGDAKSASIAAGACIAKVTRDRLMDEYAEKYPLYGFEKHKGYGTKEHLNALAKYGPSPIHRRSFAPVKAHE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOF56_ARATH
Sequence: MGLTSLQVCMDSDWLQESESSGGSMLDSSTNSPSAADILAACSTRPQASAVAVAAAALMDGGRRLRPPHDHPQKCPRCESTHTKFCYYNNYSLSQPRYFCKTCRRYWTKGGTLRNIPVGGGCRKNKKPSSSNSSSSTSSGKKPSNIVTANTSDLMALAHSHQNYQHSPLGFSHFGGMMGSYSTPEHGNVGFLESKYGGLLSQSPRPIDFLDSKFDLMGVNNDNLVMVNHGSNGDHHHHHNHHMGLNHGVGLNNNNNNGGFNGISTGGNGNGGGLMDISTCQRLMLSNYDHHHYNHQEDHQRVATIMDVKPNPKLLSLDWQQDQCYSNGGGSGGAGKSDGGGYGNGGYINGLGSSWNGLMNGYGTSTKTNSLV
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity).  Promotes expression (PubMed:19915089).  The PEAR proteins (e. g.  DOF2. 4, DOF5. 1, DOF3. 2, DOF1. 1, DOF5. 6 and DOF5. 3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969).  Involved in the regulation of interfascicular cambium formation and vascular tissue development, particularly at a very early stage during inflorescence stem development; promotes both cambium activity and phloem specification, but prevents xylem specification (PubMed:19915089).
What are the official names of this protein?
Dof zinc finger protein DOF5.6, AtDOF5.6, Protein HIGH CAMBIAL ACTIVITY 2, Protein PHLOEM EARLY DOF HCA2.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSRA_CROS8
Sequence: MSFFDKKQMITEEEALPGRNTRMPVAALHTVTGHSMTNVPEGMEVALFAMGCFWGVERLFWALPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVVYDPNVISYEQLLQVFWENHDPAQGMRQGNDVGTQYRSAIYPLTPEQEAAAQASLERFRAAMEAAGDYRHITTEIAPAKPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPEA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: YJA7_YEAST
Sequence: MCSRGGSNSRPSDYETDALPTELLKHTKDVGEEKQTLHQIFADSMVIKGYSTGYTGHTRSSPGDLVIHKRELIFSHNIVIIVSPIYMISFIILLHYQSWHFSIY
What are the official names of this protein?
Uncharacterized protein YJL007C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NANE_ECOL6
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: EFTS_STRPG
Sequence: MAEITAKLVKELREKSGAGVMDAKKALVETDGDMDKAVELLREKGMAKAAKKADRVAAEGLTGVYVHGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAEGKPANNDEALALVMPSGETLAEAYVNATATIGEKISFRRFALIEKTDEQHFGAYQHNGGRIGVISVVEGGDDALAKQVSMHIAAMKPTVLSYTELDAQFIKDELAQLNHAIELDNESRAMVDKPALPFLKYGSKAQLSDDVITAAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQVYIMDDSKTVEAYLDSVNAKAIAFARFEVGEGIEKKANDFESEVAATMAAALNN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_STRP6
Sequence: MKLMTMPSEFQKALPILTKIKEAGYEAYFVGGSVRDVLLERPIHDVDIATSSYPEETKAIFNRTVDVGIEHGTVLVLENGGEYEITTFRTEDVYVDYRRPSQVSFVRSLEEDLKRRDFTVNALALDENGQVIDKFRGLIDLKQKRLRAVGKAEERFEEDALRIMRGFRFAASLDFDIEAATFEAMRSHSPLLEKISVERSFTEFDKLLMAPHWRKGISAMIACQAYDYLPGLKQQEAGLNHLIVSLKDNFTFSDHHQAWAYVMISLAIEDPKSFLKAWKTSNDFQRYVTKLIALYRIRQERSFEKLDIYQYGKEMASLVEDLRKAQSLSVDMDRINTLDQALVIHDKHDIVLNGSHLIKDFGMKPGPQLGLMLEKVELAIVEGRLDNDFTTIEAFVREELAP
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: PDXH_ECO7I
Sequence: MSDNDELQQIAHLRREYTKGGLRRRDLPAEPLTLFERWLSQACDAKLADPTAMVVATVDEHGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHQIENNPRVSLLFPWHTLERQVMVIGKAERLSTLEVMKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSLEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RS18_SHEPW
Sequence: MARYFRRRKFCRFTAEGVTEIDYKDIVTLKNYITESGKIVPSRITGTNAKYQRQLARAIKRARYLSLLPYTDLHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: VATB_THEAC
Sequence: MPKLAYKSVSQISGPLLFVENVPNAAYNEMVDIELENGETRQGQVLDTRKGLAIVQIFGATTGIGTQGTTVKFRGETARLPISEDMLGRVFNGIGEPIDGGPEIIAKERMEITSNAINPYSREEPSEFIETGISAIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVLDSSENFAVVFGAMGITSEEANYFTNQFRETGALSRSVMFLNLSSDPSMERIILPRIALTTAEYLAFQKGMHILVILTDMTNYCEALREISAAREEVPGRRGYPGYMYTDLSTIYERAGKLKGNNGSITQIPILTMPGDDITHPVPDLTGYITEGQIVISRDLNRKDMYPGIDVLLSLSRLMNQGIGKGRTREDHRGLADQLYAAYASGKDLRSLTAIVGEEALSQNDRKYLHFADTFESRYIKQGFFEDRSIEDTLGLGWDLLADLPVQDMKRVKPDHIQKYGRWKKE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: CH10_FUSNP
Sequence: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTKNEAEVVALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDIKYLIVNADDILAVIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_AROAE
Sequence: MNATRKAARLRVLFATPECAPWAKTGGLGDVSASLPAALAALGLDVCVLLPGYPSVRQAARNARKVADIRSAHGLPSARLLRGRLPSGVPALVLDCPSLYRREGGPYQDGEGVDYTDNALRFGLLSHVAARLASAASPLVWRADILHCNDWPTALAPAYLKLGLPGAAPSLIVVHNLAFQGIFPLDVAERLGLPPESLKSEGVEYWGKLSFLKAGLYYADRIVAVSPTYAREIRTEAHGCGMQGLLETRANRLAGILNGIDMDAWNPRTDPHLDTNYDADTLEDKAPNKRALQAELGLAADDDALLLGMVTRLTDQKGIDLVLDALPELLARPVQLALLGGGDARFEQAWRQRAAARPDRIAAVIGFDERLAHRIEAGADAFVMPSRFEPCGLNQMYSQRYGTPPIVRATGGLVDSVGDFSVDGLHRGEASGFLFAEATPAALVEAVDRALKVFADRVAWRTLCCNGMARDFSWGGSAGRYARLYVAMRAAAAA
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: QUEC_PECAS
Sequence: MKRAVVVFSGGQDSTTCLIQALQDYDDVHCITFDYGQRHRAEIEVAQELSQKLGAAAHKVLDVGLLNELATSSLTRDSIPVPDYDANAQGIPNTFVPGRNILFLTLASIYAYQVGAEAVITGVCETDFSGYPDCRDEFVKALNQAIVLGIARDIRFETPLMWLNKAETWALADYYQQLDTVRYHTLTCYNGIKGDGCGQCAACHLRANGLAQYQKDAATVMASLKQKVGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DUS23_MOUSE
Sequence: MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDQGVRHLVSLTERGPPHSDSCPGLTLHRMRIPDFCPPSPEQIDQFVKIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERALAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
What is the function of this protein?
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues.  In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro.  Able to enhance activation of JNK and p38 (MAPK14).
What are the official names of this protein?
Dual specificity protein phosphatase 23, Low molecular mass dual specificity phosphatase 3, LDP-3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Weakly nuclear (By similarity).
Protein: Y4ME_SINFN
Sequence: MTVRVLNVWWDGRIVGQFTQDRHGDIGFAYSEAWLDDENTLPLSASLPKRAEPFSRRECRPFFGGLLPEESQRLVTAQALGVSPANDFALLDRLGGDVAGALQLLPEDQEPIEAGPLPDQQPTPLDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKVPLVLIDGELALPVSGQATTHILKPPIARFPGTTENEAFVMRLAAAIGLDVAPVEPRSANGRPFLVVERYDRYRDADGVVHRIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPATDVLKLLDAAIFNLVVGNADAHGKNFSILYDDQGPKMAPLYDLLSTVAYPDLSPKMAMRIGKRVTLAEMDADGWQTFAKEAGVGLPLVRRRITNLVDSTAEAVARVLEDTSDLYIDSARINHFADSVAGRAKLVRLSI
What are the official names of this protein?
Putative kinase Y4mE.
What is the protein family that this protein belongs to?
Belongs to the HipA Ser/Thr kinase family.
Protein: RL15_STRZJ
Sequence: MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIVKAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RS8A_CANAL
Sequence: MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGPKRIHSVRTRGGNQKFRALRVETGNFSWGSEGVSRKTRIAGVVYHPSNNELVRTNTLTKSAVVQIDATPFRQWYENHYGATLGKKKGGAHAAHAAEVADAKRSRKVERKLAARSGAAAIESAVDSQFGSGRLYAVISSRPGQSGRCDGYILEGEELAFYLRRLTAKK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: HIC1_HUMAN
Sequence: MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT
What is the function of this protein?
Transcriptional repressor (PubMed:12052894, PubMed:15231840).  Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840).  May act as a tumor suppressor (PubMed:20154726).  Involved in development of head, face, limbs and ventral body wall (By similarity).  Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335).  The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755).  In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755).  Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116).  Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893).  Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726).
What are the official names of this protein?
Hypermethylated in cancer 1 protein, Hic-1, Zinc finger and BTB domain-containing protein 29.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURU_PSEAE
Sequence: MKAMILAAGRGERMRPTTLHTPKPLIEAAGVPLIERQLLALRQAGVDDWVINHAWLGEQIEAYLGDGSRLGGRIAYSPEGEPLETGGGIFRALPLLGEQPFLLLNGDVWSDFDYSRLHLADGDLAHLVLVDNPAHHPAGDFHLDAGGRVGETREAGGNLTYSGIAVLHPALFEGCQPGAFKLAPLLRKAIAAGRVSGEHHRGQWVDVGTHERLAEVERLLAEHA
What is the function of this protein?
Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P (By similarity).  Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:24819062).  Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc (PubMed:24819062).
What are the official names of this protein?
N-acetylmuramate alpha-1-phosphate uridylyltransferase, MurNAc-1P uridylyltransferase, MurNAc-alpha-1P uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the nucleotidyltransferase MurU family.
Protein: GALU_ECO57
Sequence: MAAINTKVKKAVIPVAGLGTRMLPATKAIPKEMLPLVDKPLIQYVVNECIAAGITEIVLVTHSSKNSIENHFDTSFELEAMLEKRVKRQLLDEVQSICPPHVTIMQVRQGLAKGLGHAVLCAHPVVGDEPVAVILPDVILDEYESDLSQDNLAEMIRRFDETGHSQIMVEPVADVTAYGVVDCKGVELAPGESVPMVGVVEKPKADVAPSNLAIVGRYVLSADIWPLLAKTPPGAGDEIQLTDAIDMLIEKETVEAYHMKGKSHDCGNKLGYMQAFVEYGIRHNTLGTEFKAWLEEEMGIKK
What is the function of this protein?
May play a role in stationary phase survival.
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: FRDD_SALPK
Sequence: MINPNPKRSDEPVFWGLFGAGGMWGAIIAPVIVLLVGIMLPLGLFPGDALSFERVLTFTQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTAIGVITL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1493_THEPD
Sequence: MARLRYLGHAAFDVELEGFDGRKRRILLDPWLENPLSPVKPSDYRGARVDYIFVTHDHGDHLGNAVELARATGAKVVAVYELAEELSKEGVQAVGANIGGPLALEGIQAVFTPALHSSSKGAPTGVVVRGRDTAVYHAGDTGLFGDMRLIGELYAPDVALLPIGGHFTMGVVEALKAVELLRPRLAIPMHYNTFPEIRADPEKFKELVEATTRTKVVVLKPGDYVEYP
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Tpen_1493.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: RV161_CANAL
Sequence: MSWGGFKKAINRAGASVIVKDVDKTMDKDFDVEERRYKTLKTAGTNLQKAAKGYLDNIRAITNSQVTIAEIIYNLYEESKQGQSLYSNVGTYYMQSVKEFDEETVKQIDGPYRETVLDPIGKFSNYFSEIDEAIKKRAHKKIDYEQCKAKVRRLVDKPAKDAAKLPRAEKELSMAKEIYDELNDQLKAELPQLIALRVPFYDPSFEALVKIQLRFCTEGYSRLAQIQQYLDPASRDEYANGLLDGKIDDMLAQMQGLSITSLGK
What is the function of this protein?
Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.  Plays an important role in virulence.
What are the official names of this protein?
Regulator of cytoskeleton and endocytosis RVS161.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: KUP2_BRASB
Sequence: MTASATSTEGQEAASTSGFWGLTLGSIGVVFGDIGTSPLYAFREAAHGAAHGEPVSRMIVLGVLSLILWSLFIVVTAKYVLLLLRADNNGEGGTLSLMALGQRALGRRSMFLMSLGVIGASMFIGDSMITPAISVLSAVEGLKLAAPALEHYVVPLTVFILVVLFAVQSKGTARVATAFGPVMVLWFASLAVMGIVHITDDPSVLAAINPYYAVQFLLSHGTIGLVTLGAVFLAVTGGEALYADLGHFGRKPIQSAWLFFVLPSLLINYFGQGALVLSDPAAIENSFYRMVPELLLLPLVVLATAATVIASQAVITGAYSLVSQAVQLGLLPRFEVRYTSESHAGQIYLPRVNRLLLIGVMLLVLLFRTSSNLASAYGIAVSTTMVADGIMGFVVIWKLWNLRAAVAAAIIVPFVIVDLSFFSANLLKLFEGAWVPLLFGAAMAVTIWTWRRGSAILVLKTRKIEVPLDDLIGSLEKRPPHIVKGTAVFLTSDPTSVPTALLHNLKHNKVLHEHNVILTIETAQTPRVDVSERVRMEKISEKFSKVRLRFGFMESPNVPRALAVARKLGWQFDIMSTSFFVSRRSLKPSSQSGMPSWQDHLFIALSRSANDATDYFQIPTGRVVEVGTQVTI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.