PharMolix/UniProtQA huggingface dataset:
Protein: VP6_ROTB2
Sequence: MDLIETINAVVELQHRVRNLSPNTNIYQDGQTTINDYNAIASRCNGKVYNLRDQIAQLSPFQVHMPVIPISTILSTDDHETMSAGIESLFDVLAAAIRTEGSRQNRAVVTKSIEPEVLKAVLDIGIRSQFSENPYANMLQVDTAKMEQQLEPIDDPLASQKINMLAAGGATNNTGGGYHALVGRATGKTGVVTIIQGRPGAVTFNLNMKVPCSGVLSLTLLPAPGVIQLSLGNQPPNNIPVHAECVDVSTVFAEGDIVIRFELAGRVVGNANKLGTLNFPLCDRISITIEPWNANKQNNANANFNNWPAGTAQRQPTVSLFVNIINASSLIDYETHSKYLAGATYLMGTTFSEDSFIASPPNVVWTMSSLLSGAPPQYIHWTRKIACMIAAFSCKI
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: ZNT7B_XENLA
Sequence: MLPLSIKDDEYKPPKFNLVRKVSGWIRSIFSDSTSRNLFCFLCLNLSFAFVELFYGIWSNSLGLISDSFHMFFDCTALLAGLAASVISRWKTNETFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGIERALDTPEVHHERLLPVSIMGFLVNLIGIFVFQHGGGHGHSHESGHGHSHSLFNGAVSHGHSHSHGGGHGHSHGGGHEHGHSHGGGHEHGHDHSHKHGHGYGSSCHDEPPEENKGSSKQILEGVFLHIVADALGSVGVIISTILMQQYGLMIADPICSMLIALLIFVSVIPLLKQSIGILMQRTPPSLDHVLPQCYQRVQQLQGVYHLQEPHFWTLCTDVYIGTLKLVIGPEADARWILSQTHNIFTQAGVRQLYVQIDLAAM
What is the function of this protein?
Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway.  By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
What are the official names of this protein?
Zinc transporter 7-B, Solute carrier family 30 member 7-B.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein: RM41_MOUSE
Sequence: MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFQETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR
What is the function of this protein?
Component of the mitochondrial ribosome large subunit.  Also involved in apoptosis and cell cycle.  Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition.  Enhances p53/TP53 translocation to the mitochondria.  Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
What are the official names of this protein?
39S ribosomal protein L41, mitochondrial, L41mt, MRP-L41.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METK_BACCR
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKDDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELMDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFD_RICPR
Sequence: MIQQKFPATAKCFYVIDNFTKNLNQDFILSVSNEEEALQLYKQALFFSSNDNIYYFPSYDTIPYDHTSPNANIVSRRAETLTKLITNSKGKLLITHAANLLNKLPPKDFFSKYFLKLYPKIKFTMDELSMLLVENSFTRNTSSIDVGEFAVRGEIIDIILPGPKGYRINFSWDYIESIKEFDINTQISTKYCAELVISPANEIVLNSETIGNFKNNYLRNFGVNHTDNPLYEAVISGRKFAGYEQLLPLFYYSCSSLVDYLNNPICIFDNLSKQAILEFENSYNDFYLARSKANKLKVNNFYPTLSPTSLYFTASAITELLEQKNNILISYENSEQASLIGNISSISFIEKKTIFDKLFEIIKANFHKKIIICSSVLSSFERIKSIIQNYEYTFNEINKLDEAKASVINIGIIPLNQSFYTKEYLFITSSELLEEKTLYTNTNKKLKNILLELDNLKEGEFVVHKDHGIGQFLKLEAFKIQGKLHDFLKILYFGNDKLYVPVENIEVIKKYGSDNAELNKLGSVAWNKSKAKLKNRIKEISLHLIQIAAKRKLNISTPIELDLEAYDKFCANFPFSETEDQLTAINDIREDLTNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEYLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVISSKEANIIRLELASGKINIIIGTHALLHKNTKFFNLKLLIIDEEQHFGVSQKEFLKSLKSSTHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVRTSVMPFDPVIIRDALLREHFRGGRSFYVAPRIKDMEDIEKQLKQIVPELSYKIAHGKMTPSKIDEVMSEFYVGKFDILISTTIIESGIDIAEANTMIIHKADTLGLSQLYQLRGRIGRGKIRGYAYLTVASNKKITSHSLRRLEIIQNSCSLGSGFTIASHDADLRGFGNLIGEEQSGQIKEVGTELYQEMLEEQIALLKDDPIVLEQAFIPNINLGLSVFIPDSYVSDSALKIGLYRRIGNLSNEMEVEKFKDEMIDRFGLLPIEFNNLLDIVKIKLLCFKLNIENLDSGDDGFVIRFYKNADMTDKILKFVSRYSNQTKIKPNNKLVFIKKLVDKNIITEVNQLLWTLLEI
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_SERP5
Sequence: MNKKFACIGIVGHPRHPSALATHEMLFHWLVARGYSVMVERQIAQDLGLKDAVTGSLAEIGQKADLAVVVGGDGNMLGAARVLARYDIKVIGVNRGNLGFLTDLDPDNALQQLADVLEGEYIDEQRFLLETIVHKENQQCRISTAINEVVLHPGKVAHMIEFEVYIDDRFAFSQRSDGLIIATPTGSTAYSLSAGGPILTPSLEAIALVPMFPHTLSARPLVINGNSTIRLKFSQIGSDLEISCDSQIALPIQEGEEVLIRRSDFHLNLIHPKDYSYFNTLSTKLGWSKKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_ALIF1
Sequence: MAGNSIGQHFRVTTFGESHGLALGCIVDGCPPGLELTEADLQVDLDRRKPGTSKYTTQRREADEVKILSGVFEGKTTGTSIGLLIENTDQRSKDYSEIKDKFRPGHADYTYHQKYGQRDYRGGGRSSARETAMRVAAGAVAKKYLKQEFGIEIRAYLSQMGDVSIDSVDWNEIENNAFFCPDASKVDAFDELIRKLKKEGDSIGAKITVVAQGVPVGLGEPVFDRLDADVAHALMGINAVKGVEIGDGFEVVNQRGSEHRDPLTPEGFSSNHAGGILGGISSGQDIVAHIALKPTSSITVPGETITRSGEKTELITKGRHDPCVGIRAVPIAEAMLAIVVMDHLVRHRGQNFGVQTETPKI
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: FOLD_EXISA
Sequence: MAVVIDGKQVAASYRETLKERVAELRARGIVPKLKVVLIGDDPASHSYVRGKERAAEEIGIDSQVLRFDETISEKELLDLIDLMNADEEVHGILVQLPLPKHIDESRVIMRISPEKDVDGFHPENVGKMMLGLDTLLPCTPHGILHLAKTQTEIAGKHVVVVGRSQIVGKPVGMLFLNESATVTYCHSKTADLGEMTRQADILIVAVGRAGLVTSDMVKPGALVIDVGVNRVEGRLVGDVDYEAVKEKASAITPVPGGVGPMTITMLMHNTVEVASRG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HEM1_STAAB
Sequence: MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVDQIHTGCYYIQRFLARAFGFEVDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQIRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIADNAVSVSYAAVELAKKVFGKLKSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLLESADIVISSTSAQTYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDVDDLKGLVDANLRERQLAAATISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETMDSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKELSSDKKSNEKLELFQNIFDIEAECPHEQAKQQKESKVKEISARRIFSFE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: BBP1_ASHGO
Sequence: MGWLGDNSEDSTGAVRWVMDALLGKRESPSQKYRREFAQDDTNNRLQVPRSAGARRRRTGSLDSEFRARYELLPDETEGAGASLLSPVDLRPAGTAARESGTPGRAGWAGGAAGTLGGGDGGCDGGRDGDTFGRARGSEDVAFRPPRADNPLVSALFAQPSSPDAGLPGSFPGRAPRARDPTHDYLALLDQLARNNRDLHSLQQDLEAREERDRRETSYRDRYLQLRQELIQELKQSKTMYDNYTALYERYKALKDAEHPDYAELVSKLEAQIVDLTIADQQKDRRHQEELLRLQLQYEARIHELERKLNHQNSTYTANDTATPASTVDSGSISPYHKYNDTIDTQFLNHIVK
What is the function of this protein?
Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.  Connects the central plaque of the SPB with the half-bridge.  Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity).
What are the official names of this protein?
Spindle pole component BBP1.
What is the protein family that this protein belongs to?
Belongs to the BBP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associates with the periphary of the central plaque.
Protein: COAA_SHEDO
Sequence: MANSIQDALYLSFEREQWAELRKSVPLTLSEAELTQLKGMNEKLSLDEVTDIYLPLSRLLNLIVGAKQQRGLVIDKFLSQQAPKSPYIISIAGSVAVGKSTTARILQTLLQRWPEHPKVDLVTTDGFLYPLAELKRKGLLQRKGFPESYDTKLLGEFISAVKSGDNNVKVPLYSHITYDRLTDQHQVIAQPDIIILEGLNVLQTGLDTLVETRRPFVSDFVDFSIYVDADESLLKDWYQQRFLQFRHGAFNDPRSFFHHYATLSDGEANAIAANIWDTINGPNLQLNIQPTRERAKLILKKGKDHLISQVLMRR
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF859_ASFK5
Sequence: MCAGFYVAVHPWLETQSLHKVGHTGNLAARLHDGSYTTCFTDEWRYCFTLETPTKKDAQKIEAGVLYCAQFFRVKNKELLCLLPEKIKQLAEDVANCLNISYTLCDAPTYEMNDSTIVVEPSSPSDPLISKEKLRHLVITPVEDEDRFADDVLFFSTGETRTTIEDRLYQREAANMGYQELQRSGRAILQMACRCGKTRVAYLILSNYLQGKVLYLVPGLSLLRQTLEKLYLYGISLKNVMLVGSDQTRIVLNHDTIEMTTNPVIIVKRIQEASSLLVIATYQSSTLLVDDFDLIISDECHRICGEWETRPFTHVLLNFKKGHRLFLTATPRYDTPLSMKNRELFGGVAFRYYLREGIEAGYVNDFELQMVAAPKLAHQLSNREETTKQIIVKQIIMALAYLKTNVRSPKMLVFTRDIKQAKELYAELVDLGVYALIAHSTLPRQVILKTFTEFCSSKEPVILLNCRLFQEGVEVPELNAVFFAAPRHSPRDIIQSICRPLNKQVQKPHATIFLPLEVNTENVCLDKFSSIIPFADALASEDPRFYEHLLNPSEVAYPINWIGAHGSVAELLQLARHAIRYGTQGKIDRLTRSERLPWKAAFAELKRTVEICCRYPKINDGFHFGGATLRFDTWYKWVIKSYLQYKNNEPSSLEPYQVLDLESLQDWTTRGVGGPYPWEESMAFLETWLAQNKGELVAIDIHQGGWIGLDATPMERLSGVLTTVSQRDGRSYGKNRKLRPKKGFMIPPQQAKDLDRIFGKHNLKWRKDRDNGFLKEDEHGNYTGEPTCIQEAYQTFKEYVKTNPEYIEKYWPGYAKGKHKHQELPHIWESGLAPPRYKAFKDGNKRLIQRSPKKKDVKN
What are the official names of this protein?
Probable helicase A859L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus helicase A859L family.
Protein: YQJE_SHIFL
Sequence: MADTHHAQGPGKSVLGIGQRIVSIMVEMVETRLRLAVVELEEEKANLFQLLLMLGLTMLFAAFGLMSLMVLIIWAVDPQYRLNAMIATTVVLLLLALIGGIWTLRKSRKSTLLRHTRHELANDRQLLEEESREQ
What are the official names of this protein?
Inner membrane protein YqjE.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GATA_LEGPC
Sequence: MEHYSLAQLSKALHNREFSSVELTQHCINKIQSNKDLNAFISLDEDQALKEAQSADLVLKNGEGKPLTGIPMALKDLFCTKRLNTTCASKMLANFQAPYDATIVTKFKQNGAIIIGKTNMDEFAMGSSNENSYFGSVKNPWDRERVPGGSSGGSAAAVAGNLVPFAIGSDTGGSIRQPAAFCGISGIKPTYGLVSRYGMVAFASSLDQAGPFAKSAEDLAMILHCIAGFDSKDSTSVDRVIPDYSAEIKKPVDKIRIGLPSCFFQPQVEKGIQDAIHDAVKLFENLGAEIIEIDLKLQPLWVPCYYVIACAEASSNLSRYDGIRFGHRSKSASTLIELITNSRSEGFGNEVKRRILTGTHVLSTGFFNAYYLHAQKVRRLIRDELITTLNSVDVIIGPTTPTTAFKLGEKINDPIQNYLADVFTVAANLAGLPAISIPTGFENKLPIGLQLMGKHFSESRLLAIAHHYQQHTNWHLANPNKQG
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: MRP6_MOUSE
Sequence: MNRGRSMATPGEQCAGLRVWNQTEQEPAAYHLLSLCFVRAASSWVPPMYLWVLGPIYLLYIHRHGRCYLRMSHLFKTKMVLGLALILLYTFNVAVPLWRIHQGVPQAPELLIHPTVWLTTMSFATFLIHMERRKGVRSSGVLFGYWLLCCILPGINTVQQASAGNFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSVGAPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRPDRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWADDPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQKGLFYRLAHESGLA
What is the function of this protein?
Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.
What are the official names of this protein?
ATP-binding cassette sub-family C member 6, Multidrug resistance-associated protein 6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein.
Protein: PTA12_MAIZE
Sequence: MASCYNPWRLFPGMSTAVPAGPVTAPAHSRTCKSSKVFSALPHRRGLLFLGTRRARIKCVKDDSLHFDPSKIEPPPYSSYFDSTSGQLEPASGARASIPGKEYWPEGTAARVRAARAPAPVGESAGMPSFGTKPGSRRRGYKEQVTSASGTEGAQTDDRKDGDEPDVAIIGSGDDALEEIKDSVDEYVIYETPEEEELSEYDMDKMMGRPHPFIDPAKAMSLGEPKTSEELWWHWRRKSQEEEMWSRWQRRRPDVDTVFAKAMAETGQIKIFGDHPSRTEAALAKTRRHLYKEERLEAEQRRLEEIGPIAYYSEWVEAYKNKDTSREAIQKHFEETGEDENVQLIKMFQHQTAGEYRIMMGTDVRIQRDPLAMRMREDQIKQIWGGDPVYPTINYVQDPDEVIDYRGPEFHEPTPEVVPYLMEHGIMITKEELYARLNEEREDVNQDITYIPEAKDPMATAIDIGEHSYNEDSDDEDEDVDKAAAQPQSLEDEEDDRDDVAEVEEKVNQNWSALKSTGQAEKPKEKSKKDEMTLKEAIDDSENLTDFLMDFEETE
What is the function of this protein?
Required for the activity of the plastid-encoded RNA polymerase (PEP) and full expression of genes transcribed by PEP (PubMed:24246379, PubMed:25599833).  Required for the proper build-up and formation of the PEP-complex.  Binds single-stranded (ss) DNA and RNA, but not double-stranded (ds) DNA (PubMed:25599833).
What are the official names of this protein?
Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic, ZmpTAC12.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Nucleus.
Protein: RS7_ECO8A
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ENV_HV1S9
Sequence: METQTSWLSLWRWGLMIFGMLMICSARENLWVTVYYGVPVWRDAKTTLFCASDAKAYSTEKHNVWATHACVPTDPNPQEMSLPNVTENFNMWKNDMVDQMQEDIISVWDESLKPCVKITPLCVTLNCSDVNSNNSTDSNSSASNNSPEIMKNCSFNVTTEIRNKRKQEYALFYRQDVVPINSDNKSYILINCNTSVIKQACPKVSFQPIPIHYCAPAGFAILKCNNKTFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSVAEGDIIIRSENISDNAKNIIVQLNDTVEIVCTRPNNNTRKGIHMGPGQVLYATGEIIGDIRKAYCNISRKDWNNTLRRVAKKLREHFNKTIDFTSPSGGDIEITTHSFNCGGEFFYCNTSTLFNSSWDENNIKDTNSTNDNTTITIPCKIKQIVRMWQRTGQAIYAPPIAGNITCKSNITGLLLTRDGGNRNGSENGTETFRPTGGNMKDNWRSELYKYKVVELEPLGVAPTKAKRRVVEREKRAVGIGAVFLGFLGTAGSTMGAASITLTVQVRQLLSGIVQQQSNLLKAIXAQQHLLKLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTNVPWNASWSNKSYEDIWENMTWIQWEREINNYTGIIYSLIEEAQNQQETNEKDLLALDKWTNLWNWFNISNWLWYIKIFIMIIGGLIGLRIIFAVLAIVNRVRQGYSPLSFQTLIPNPTEADRPGGIEEGGGEQGRTRSIRLVNGFLALAWDDLRSLCLFSYHRLRDFVLIAARTVGTLGLRGWEILKYLVNLVWYWGQELKNSAISLLNTTAIAVAEGTDRIIEIAQRAFRAILHIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: PAXD_PENPX
Sequence: MQSDELQIPPWESLAEGLGFSNADEEYWWTVFGQPLNKLMDWADYSTSEKYRVLAFIHRYVIPTCGPRPKPNGDQYWDTFMGFDHTPIQVSINFYNSKATVRTGNIPISEASGTTEDPINQKASLDTIASQRHLVPGHNLRLFKHFTDAFFIPNEEANILNAELENRTIAMQAVQCMLSYDFPYRQIQTKVAICPMWKSMQVKRPMGDLMISSIKDLGIDAADYMKSLKVIEDFINSEKAVQSGAYAIFFAFDTMLTDDYQRTRVKIYFATQSTAFNNMVDIFTLGGRLDGPEMQRATKELRKLWMSTMAIPDGLRDDETLPKSPLPCAGVIFNFEIWPGADKPNPKIYLPCAYYGKDDLDIADGMDSFFKDQGWSKSFHSYKDNYIKAFVKDGKVMCRHHDISFSYKGQGAYITAYYKPELSEYADPSVWAPKLFKA
What is the function of this protein?
Indole diterpene prenyltransferase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005).  PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005).  Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005).  Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005).  Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005).
What are the official names of this protein?
Indole diterpene prenyltransferase paxD, Paxilline synthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: EIF3I_ASHGO
Sequence: MRPIMLMGHERSLTQVKYNREGDLIFTSGKDNVASVWYAMNGERLGTLEGHNGSIWSIDVDQHTEYAVTGSADFSVKVWRVRDGSIAHSWDTRTPVRRVEFSPTGDRVLAVLDNVMNYAGAIVVFSVTRDANNQITGFNSGLSCEILTQEGCAPVLVASWSYDGKYIVAGHQDGKISKYNGVTGECLEIKDLHKQRVSDIQFSLDRTYFLTTSRDSYANLVDVETFEVLKTYETDCPLNSGCITPLKEFVILGGGQDARDVTTTSAREGKFEAKFYHKLFQVEIGRVDDHFGPVNYIAVSPQGTSYASGGEDGFVRLHHFDKSYFDFKFDVEKSADAQKKVDTADR
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 39 kDa subunit homolog, eIF-3 39 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.