Protein: POM1_SCHPO
Sequence: MGYLQSQKAVSLGDENTDALFKLHTSNRKSANMFGIKSELLNPSELSAVGSYSNDICPNRQSSSSTAADTSPSTNASNTNISFPEQEHKDELFMNVEPKGVGSSMDNHAITIHHSTGNGLLRSSFDHDYRQKNSPRNSIHRLSNISIGNNPIDFESSQQNNPSSLNTSSHHRTSSISNSKSFGTSLSYYNRSSKPSDWNQQNNGGHLSGVISITQDVSSVPLQSSVFSSGNHAYHASMAPKRSGSWRHTNFHSTSHPRAASIGNKSGIPPVPTIPPNIGHSTDHQHPKANISGSLTKSSSESKNLSTIQSPLKTSNSFFKELSPHSQITLSNVKNNHSHVGSQTKSHSFATPSVFDNNKPVSSDNHNNTTTSSQVHPDSRNPDPKAAPKAVSQKTNVDGHRNHEAKHGNTVQNESKSQKSSNKEGRSSRGGFFSRLSFSRSSSRMKKGSKAKHEDAPDVPAIPHAYIADSSTKSSYRNGKKTPTRTKSRMQQFINWFKPSKERSSNGNSDSASPPPVPRLSITRSQVSREPEKPEEIPSVPPLPSNFKDKGHVPQQRSVSYTPKRSSDTSESLQPSLSFASSNVLSEPFDRKVADLAMKAINSKRINKLLDDAKVMQSLLDRACIITPVRNTEVQLINTAPLTEYEQDEINNYDNIYFTGLRNVDKRRSADENTSSNFGFDDERGDYKVVLGDHIAYRYEVVDFLGKGSFGQVLRCIDYETGKLVALKIIRNKKRFHMQALVETKILQKIREWDPLDEYCMVQYTDHFYFRDHLCVATELLGKNLYELIKSNGFKGLPIVVIKSITRQLIQCLTLLNEKHVIHCDLKPENILLCHPFKSQVKVIDFGSSCFEGECVYTYIQSRFYRSPEVILGMGYGTPIDVWSLGCIIAEMYTGFPLFPGENEQEQLACIMEIFGPPDHSLIDKCSRKKVFFDSSGKPRPFVSSKGVSRRPFSKSLHQVLQCKDVSFLSFISDCLKWDPDERMTPQQAAQHDFLTGKQDVRRPNTAPARQKFARPPNIETAPIPRPLPNLPMEYNDHTLPSPKEPSNQASNLVRSSDKFPNLLTNLDYSIISDNGFLRKPVEKSRP
What is the function of this protein?
Polarity factor involved in localization of polarized growth and cytokinesis (PubMed:11230130, PubMed:11950884, PubMed:14663827, PubMed:17077120).  Forms an intracellular gradient that serves to measure cell length and control mitotic entry (PubMed:19474792, PubMed:19474789, PubMed:21703453, PubMed:24047646).  Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity (PubMed:19474792, PubMed:22684255, PubMed:24316795).  Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1 (PubMed:19474792, PubMed:24508166).  Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activity (PubMed:24982431).  Acts as a negative regulator of mid1 distribution, excluding mid1 from non-growing ends, which prevents division-septum assembly at the cell ends (PubMed:17140794, PubMed:17077120, PubMed:17543869).  The pom1 polar gradient also mediates mitotic entry by regulating cdk1 (PubMed:19474789).  Plays an essential role in proper localization and phosphorylation of a GAP for cdc42, rga4, which ensures bipolar localization of GTP-bound, active cdc42 involved in F-actin formation (PubMed:18328707).  Phosphorylates multiple other substrates that function in polarized cell growth, including tea4, mod5, pal1, the Rho GAP rga7, and the Arf GEF syt22 (PubMed:25720772).
What are the official names of this protein?
DYRK-family kinase pom1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
What are the subcellular locations of this protein?
Cell tip. Cell septum. Cell membrane; Peripheral membrane protein. Note=Forms an intracellular gradient that serves to measure cell length and control mitotic entry (PubMed:19474792, PubMed:19474789, PubMed:21703453, PubMed:22342545, PubMed:26150232). Localized to the septum at the time of cytokinesis (PubMed:14663827). Tea4 recruits pom1 to the cell cortex from where it then moves laterally at the plasma membrane, which it binds through a basic region exhibiting direct lipid interaction (PubMed:21703453). Pom1 autophosphorylates in this region to lower lipid affinity and promote membrane release (PubMed:21703453). Tea4 triggers pom1 plasma membrane association by promoting its dephosphorylation through the protein phosphatase dis2 (PubMed:21703453).