PharMolix/UniProtQA huggingface dataset:
Protein: 36016_ASFWA
Sequence: MLSLQTIAKMAVATNTYSKCHYPILKVFGLWWKNNTLNGPIKICNHCNNIMVGEYPMCYNHGMSLDIALIRAVKERNISLVQLFTEWGGNIDYGALCANTPSMQRLCKSLGAKPPKGRMYMDALIHLSDTLNDNDLIRGYEIFDDNSVLDCVNLIRLKIMLTLKARIPLMEQLDQIALKQLLQRYWYAMAVQHNLTTAIHYFNNHIPNIKPFGLRCALYFNDPFKIHDACRTVNMDPNEMMNIACQQDLNFQSIYYCYLLGADINQAMLMSLKYGHLSNMWFCIDLGADAFKEAGVLAEKKNRRVLQHILGLNIFKRELIPPCKDPDPYQIQILLKNYILKNVSTVFTYYCQ
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-16R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: RL24E_METM6
Sequence: MEWKTCSFCEGTIEPGCGKKYVKKDGSVMHFCSSKCEKNFKLGRVGRKLKWTNTFKRINRGQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: NRDR_SACEN
Sequence: MRCPFCRGDDSRVVDSREVEDGQAIRRRRSCSGCGRRFTTIEELVLSVVKRSGVTEPFSREKVVRGVARACQGRPVEEDALQQLAHQVEDTVRSLGVSELPSHEVGLAILGPLRELDEVAYLRFASVYRAFSSVEDFEKEIADLRSLRGAARLPEGPEAAQGGPESKAGNGQAAGSGDPEGVKAEKSSE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MURC_ECOK1
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKKLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YE66_SCHPO
Sequence: MSATSREGNKTKIGIVGGGIIGICTAFYLTEEQEYKKGELDIFIFESKEIAGGSSGIDSAILTKLCQNEIIQPLSTLALKLYEGLDKKFDGKKNWEYRTANSWFCKMKWDNTNVAKVPDTLQWLQRERMQKCSSIGSGNDFAMINPKLFCQFMAKEIEKRGVKFIFGSVKEVSKHHITYVPKQEAEDTIIKAQVHKTLVSAGPWTGYLLPFTGIAGLCIPIIHLSVGNFPVGDSIVVCCLNTMGNLNICKTTEIFSKNREQLIFMGTPKFHLLPKDSNRCFFNPFEIIELKEMTDLVLSENTKSNYLDASFKFLPTSRITGIPIISTTKSGVFVAAGHANWGITQAPATGLCMAEMLLGKEKTSINTDPFHLNLGE
What is the function of this protein?
Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi.
What are the official names of this protein?
Putative oxidoreductase C6G10.06.
What is the protein family that this protein belongs to?
Belongs to the TDA3 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein.
Protein: RS29_MAGOY
Sequence: MSHDSVWNSRPRTYGKGARSCRVCTHRAGLIRKYGLDICRQCFREKAADIGFVKHR
What are the official names of this protein?
40S ribosomal protein S29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: KDPC_RHOP5
Sequence: MLKEIRPALVMLVALTALTGLVYPLAMTGVAQLLLPAQANGSLIEQNGQVIGSALIGQAFTDARYFHGRPSATTAPDPQDSSKTVPSPYNAANSMGANLGPTSAALKERLTADVDAAKQDNPTSPVPVDLVTSSASGLDPDISPEAALFQVPRVAKARGIDEAKLRALIDSQIQGRELGLLGEPRVNVLKLNLALDRMAA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LIPB_RICPR
Sequence: MIRFITLQNLMDYQVTLKLMEDYVNKVINDNEPEIVYLVEHSEVYTAGTNYKQEELLNYDDIPVIYTGRGGKFTFHGPGQRVIYPILNLALPNRHKDLKLYIKMLEEWIINSLNYFGIKGYLIKDKVGIWIKVNKGEFAKIAAIGVRVRKWVTYHGIAINISTDLCKFNGIIPCGLESSLVTSLNQLGIYVEMSEFDKIIQTEFNKIFK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_BACFR
Sequence: MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGIAEACKAGELLKENGFNFDKAYTSYLKRAVKTLNCVLDRMDQDWIPVEKSWRLNEKHYGDLQGLNKSETAAKYGDEQVLIWRRSYDIAPNALSEDDPRNPRFENRYQEVPDAELPRTESLKDTIERIMPYWKCIIFPNLKTADEILVVAHGNSLRGIIKHLKHISDEEIVKLNLPTAVPYVFEFSDELNLEKDYFLGDPEEIRKLMEAVANQGKKK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: ACT_COPC7
Sequence: MEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGFALPHAILRLDLAGRDLTDYLIKCLGERGYPFTTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPAFLGLEAAGIHETTYNSIFKCDLDIRRDLYGNVVLSGGTTMFSGIADRMQKELLALSPASMRVKIVAPLERKYSVWIGGSILASLSTFQNLWCSKQEYDESGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: IF1A_NATPD
Sequence: MSDNEGRKNLRMPEGDEVFAVVTNMLGANRVKVRCMDGTERTARIPGRMQKRIWIREDDVVLVEPWDWQDEKADVVWRYEKQEADQLREEGHITDSV
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: OBG_NEIMA
Sequence: MKFIDEAKIEVAAGKGGNGATSFRREKFVPRGGPDGGDGGKGGSVWAEADENTNTLVEYRFVKRYQAKNGEKGHGSDRYGAGADDIVLKMPVGTLIRDLDTGENVADLTYHGQRVCLAKGGKGGLGNIHFKSSVNRAPKQSTPGEEGEARSLQLELKVLADVGLLGMPNAGKSTLITAVSAARPKIANYPFTTLHPNLGVVRIDENHSFVMADIPGLIEGAAEGAGLGHRFLKHLSRTGLLLHVVDLAPFDETVNPAEEALAIINELRKYDEELYGKPRWLVLNKLDMLDEEEARARTAAFLEAVGWDYPKPDDRFQFDMETPRLFQISALTHQGTQELVHQINQYLIEKKRIEAEKAEAERAATNVEIAEQQPKTDTGVFKPE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_PROM1
Sequence: MELIPLIRDKSRLSDFLKDIPNDPGCYLMKDGEDRLLYVGKSKKLRNRVRSYFRSGNELSPRISLMVRQVADIELIVTDNESEALTLESNLIKSHQPYFNVLLKDDKKYPYVCITWGDKYPRIFLTRKRRQRQLKDKYYGPYVDVYLLRKTLFSIKKLFPLRQRRIPLYKDRTCLNYSIGRCPGVCQEEISSEDYKNTLKRVEMIFQGRTDELRILLEKQMISFSESLKFEEAGSVRDQLKGIDRLYESQKMIIPDSSVCRDIIAMASEENISSVQIFQMRSGKLIGRLGYFSDNSNFNSSQILQQVIENHYSNVDPVEIPSEILVQHQLVNNILISDWLSEIKKQKVNINVPKRSRKAEIIKLVEKNANLELQRIKQSHDKNLVELDDLTNILDLENIPKRIECYDISHIQGSDAVASQVVFIDGIAARQHYRRYKIKSPNIKIGHSDDFESMAEVITRRFRRWARFKEEGGDINALLSNQSSVLDNLNLNDWPDLVVIDGGKGQLSSVVAALEELKLDQNLNVISLAKKKEEVFIPNVKQSLVTESNQPGMLLLRRLRDEAHRFAITFHRQKRSQRMKRSQLNEIPGLGPQRIKLLLEHFRSIEAIQMATFSELSSTPGLGRSTAVVIRNYFHPDKNK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLN1A_STAAW
Sequence: MPKRTFTKDDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMFDGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDGTPFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY
What is the function of this protein?
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism.  It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.  Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA.  During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation.  Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity.  In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_STUS1
Sequence: MDPRSEVLLRQAELFGGRVLLAGLPADDLLGQLAGATAWSWHAGEQQQLDKRFGGRCSFGVAPPQGVFDTAVLFLPKSRELTDYLLQTLAARLPGRPLYLVGEKRGGIERAAKQLGSFGRARKLDSARHCQLWQVEVEQAPAAPNLDALARHFTLQLADGPLEVVSLPGVFSHGRLDLGSALLLEHLDNLPGGRLLDFGCGAGILGATLKRRYPQSELVLLDVDAFAVESSRRTLAANGLEAEVIAGDGIDAAPRQLAAIISNPPFHQGVHTSYHASETLIERAAEHLQASGEMRIVANAFLRYPPLIERHLGTCQTLAERDGFRIYRAVRG
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
Protein: GATY_SALTY
Sequence: MFIISSKNMLQKAQHAGYAVPAFNIHNLETLQVVVETAAEMRSPLIVAGTPGTFSYAGMGNIVAIAGDLAREYNLPLAIHLDHHESLADIESKVMAGIRSVMIDGSHFPFEENVALVKSVVDFCHRYDTSVEAELGRLGGIEDDLVVDSKDALYTNPQQAREFVARTGIDSLAVAIGTAHGMYAAEPKLDFERLAEIRALVDIPLVLHGASGLPESDIRQAISLGVCKVNVATELKIAFSDALKEYFLQNPKANDPRHYMQPAKQAMKEVVRKVIHVCGCEGQL
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: COBT_RHIEC
Sequence: MSVSGLPFDDFRTLLRELPGPDARALAAARERDAQLTKPPGALGRLEEIAFWLAAWTGRAPAVNRPLVAIFAGNHGVTRHGITPFPPAVTQQMVENFAAGGAAINQICVAHDLGLKVFDLALDYPTGDITEEAALSERDCAATMAFGMEAIAGGTDLLCIGEMGIGNTTIAAAINYALYGGSARDWVGPGTGSEGDMLERKIAAVEKAVALHSDHLDDPLEIMRRLGGREIAAMAGAILAARIERIPVLIDGYVATAAAAILKAANPAALDHCLIGHVSAEPGHLRSIEMLGKTPLLALGMRLGEGTGAALAAGIVKAAAACHSGMATFAQAGVSGKH
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: KDKA_STRMK
Sequence: MVAFDANEALTPCREGRGIGAILFDRERLRQAEVGLFSPQHWGSKARPVGEGGRGSAWFIDAPFGASVLRHYLRGGLAAKISHDQYLWRGSDRTRSFAEFRLMRALREKKLPVPRPIAAYYMREGLRYRAAILMERIEGVRSLADRALVAGRGAPWEETGRLIARFHRAGLDHADLNAHNILFDGNGHGWLIDFDRGVIRIPATAWRERNLKRLLRSLIKLRGERSVEDVQKDYARLRRAYDMAWNRGT
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
What are the official names of this protein?
3-deoxy-D-manno-octulosonic acid kinase, Kdo kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. KdkA/RfaP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HSP74_CANLF
Sequence: MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVKYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSSYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCDDLLARVEPPLRSVLEQAKLRKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYSISLRWNSPAEEGSSDCEVFTKNHSAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFLVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVLKFEENEEPMETDQNAKEEEKMQVDQEEPHAEEQQQQTPAENKAESEEMETSQAASKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLKKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKMRFQESEERPKLFEELGKQIQQYMKVISSFKNKEDQYDHLDAADMLKVEKSTNEAMEWMNNKLNLQNKQSLTVDPVVKAKEIEAKIKELMSVCGPIISKPKPKVEPPKEEQKNAEQNGPVDGQGDSPGPQAAEQGTDTAVPSDSDKKLPEMDID
What are the official names of this protein?
Heat shock 70 kDa protein 4, Heat shock 70-related protein APG-2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_CALS8
Sequence: MANKTRWIKSRIKSVNETKKITRAMYLISASKMKRSRDRLDSTRPYFEKINEFMKDLVVHGMQTNHILFEGSYKEGQKRLGVIVISGDKGLCGGYNANVIRSTLNLYENLSNKGEVIFFPIGTVGKNFLSRHGYKVEDNFNYQTQSVSVKVAKGIAQNVVKKYYRGDIHELYIIYTKLISTIKQDVVVKKLLPLDPSEFVSGEFKKDETIRYEPSPTNVLDVVIYEYLKGIIFGAMMDSYVSELAARMTAMDNATKSADEMIQKLVLKLNRERQAVITQEISEIISGAAALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TAT_HV1H2
Sequence: MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: TRMB_BACC2
Sequence: MRLRHKPYAMDRINEYSHIVIGNPEERAGNWKEVFGNEQPIHIEVGTGRGRFMYDMAKANPHINYIGIEKFTSVVVDALDKLIEEEVPNLKLINKDAEDLTVFFAKGEIDRVYLNFSDPWPKKRHTKRRLTYKTFLRNYEEVLVEGGEIHFKTDNQGLFEYSLMSMAEYGMLLTYLSLDLHNSDFEGNIMTEYEEKFSSKGHRIYRVEAKYRTEPMQ
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ISPE_SALAI
Sequence: MTEAWRPDGDEPRGVSGPFRVRVPAKINLHLGVGPLRPDGYHELNTVYHAISIHDELTARRGDTLALTMEGEGAGELALDDSNLVIRAARALAAHAGVPPYARLHLRKQIPLAGGLAGGSADAAAALVACDALWGTGLSRDELAGIAADLGSDVPFLIHGGTALGTGRGEAVSPVLARPTVWHWVVAVADGGLSTPVAYRELDRLRDAGAASTPLGSSDALLAALRQRDPRVLAGVLGNDLQDAALALRPSLAATLKAGEAAGALAGIVSGSGPTCVFLAANAADAERVAGELSALDVCRQARTARGPVAGARVG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: LOLA_YERPB
Sequence: MKRLLVACCFLSGLISASALADASTDLQNRLSKVNSFHASFSQAVTSSDGAVVQEGEGELWVKRPNLFNWHMTSPDESVLISDGETLWFYNPFVEQATATWLKNATGNTPFMLITRNNPDDWKQYNVKQKGDDFELTPKSASGNLKQFAISVTPSGTIKSFTAVEQDGQRSAYTLKSQQSSVVDASKFTFTPPKGVTLDDQR
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYM_ECOL6
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDKYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAIREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKEEVKATAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_TREDE
Sequence: MNSGFFLSPPNYDSPAELKSLLETLGFAMQKKFGQNFLIDKKTRENLISFLTLDKGTRVWEVGPGLGAMTYLLLEKGVHLTAFEIDKGFISLLKKIFLENSKQNFTLIEGDVQKNWLPYLIEHGKPNVFFGNLPYNIASDLIASTVEAGVVFDTMLFTVQKEAAERITARPGNKNYTAFSVLCSLFYECKIVKTIPASAFWPQPNVESAAVLFKAKKEFAEYKNFKLFIKIVKALFSSRRKNIKNNLGSWMKSNGYGDKIDLVLERSGLSGNLRAESLALYDFLLLSDIIGHL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.