PharMolix/UniProtQA huggingface dataset:
Protein: PTHR_BOVIN
Sequence: MLWRLVQQWSVAVFLLSYSVPSCGRSVEELGRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGKYLTQETNKVETYKEQPLKTPGKKKKSKPGKRKEQEKKKRRTRSAWLTSYVAGTGLEEDYLSDISATSLELNSRRH
What is the function of this protein?
Osteostatin is a potent inhibitor of osteoclastic bone resorption.
What are the official names of this protein?
Parathyroid hormone-related protein, PTH-rP, PTHrP.
What is the protein family that this protein belongs to?
Belongs to the parathyroid hormone family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted.
Protein: ATPA_EHRCR
Sequence: MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANGITGIVLGLDCDTASVVVFGDERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGAGSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIPIGRGQRELIIGDRKTGKTAIAIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASDTVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFFLHSRLLERAAKMSDKEGGGSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFYKGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYRELEDFAKFGSDIDVHSQKVLDRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPDVLSSILNNFTDDVKDLLLEIIGKVTSNFE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EX7S_BACHK
Sequence: MENKLSFEEAISQLEHLVSKLEQGDVPLEEAISYFKEGMELSKLCDEKLKNVQEQMAVILGEDGELEPFTALGDEA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REXO1_MOUSE
Sequence: MLRSTGFFRSIDCPYWAGAPGGPCRRPYCHFRHRGARGPGAPGSGGAASPASGLGYDPYNPELPQPPVQRENGALGQGDGMLELELVNQAIEAVRGEVELEQRRYQELLETARGHSAGPSALAPCSPATSIDDDDTFSLALTYTPGGLLSPDAAYQPTPLAVPAEPGHKYSLAPSDRSQGRAAGGAGALEYVPKAVGQPRRCGRPVSGGKYVVDSSKPSTDLEYDPLSNYSARHLGRASARDERATKRPRGSRGAEPYTPALKKPCDPFGGCEARFSDSEDDVTSPPKADVSSPKAGADPESKAPGKPVSKEGREHEDGGLRGTKEMAVQYDVEDLGQPPKAPDTVSVVKPGSPARASQDARVPKEGKAKKKKSGTSASLSHKDKVRKKDKKKEKDPARPRGKEKVCTDKKKLPASNPRGKAQGPEGTKKKPSSATTVASSGKGGSGRPSSTGPQDSGPGPHAPLAWKAGSAKKMSSGKLVERKARSLDEGAPQDTPKLKKRALSHAELFGDESEEEDSSLGAGAPRVWPPTLPSLSSDSESDSDSSLGLDETKVPKRLKAAPPASPVPPSPLSSSSSSSGASQCAEEDVDYSALEKEVDFDVDPMEECLRIFNESTSVKTEDKGRLARQPPKEKAEEKTHAGLTTLFPGQKRRVSHLCKPGKESEAPKRTPVAPPARPPTAQEVCYRRAQLAQRDSASWLQAAPRPTERLSSVHISAPGEKRRIAHVPNPRLAAAPTGAKRALSASSSQASHGPEPGSQPLKTRTLSGMASKTTTTVTPKRIAHSPSLQSLKKPVIPKEFGGKVPTVVRQRYLNLFIEECLKFCSSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLVPNTVPNLSKASGRRVVSHEVVLGGKLAAKTSFSLSRPSSPRVEELKGTALYSRLREYLLTQEQLKENGYPFPHPERPGGAIIFTAEEKKPKDPSCRICCRCGTEYLVSSSGRCVRSEECYYHWGRLRRNRVAGGWETQYMCCSAAVGSVGCQVAKQHVQDGRKENLEGFVRTFQKELPEDAHAGVFALDCEMSYTTYGLELTRVTVVDTDMQVVYDTFVKPDNEVVDYNTRFSGVTEADLVDTSITLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHGTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDASACMHLVIWKIREDAKTKR
What is the function of this protein?
Seems to have no detectable effect on transcription elongation in vitro.
What are the official names of this protein?
RNA exonuclease 1 homolog, Transcription elongation factor B polypeptide 3-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the REXO1/REXO3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CASB_RAT
Sequence: MKVFILACLVALALAREKDAFTVSSETGSISSEESVEHINEKLQKVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGPIISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQAQIVQAFPQTPAVVSSQPQLSHPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTLQFLATQQLHSTSV
What is the function of this protein?
Important role in determination of the surface properties of the casein micelles.
What are the official names of this protein?
Beta-casein.
What is the protein family that this protein belongs to?
Belongs to the beta-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRF_TROW8
Sequence: MGIMCSGDVSERMNKTIELLKEQFLSIHSGRVNSGQFEKVMVDCEGASVPLVSLASIRVLNANTIVVTPYDSALLSQIDRALRNVPNIGTPGNDGECIKIVMPQLTEARRHEYVKQARVKAEEARVSARNIRRKARASLDAMGLAKDEIVRREKELDKLTKDVISVVDDLLRHKESELLRL
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFCL_SULIK
Sequence: MIQWFLKYRPRSLKDVENQDGAKKELQEWIESWLNGKPNAKAVLLHGPPGVGKTTLAEALAHDYNLELLEMNASDSRKLQDIKSVAEKASVYGSIFGTRGKLILLDEVDGINVREDTGAIQGILELIEKTKYPIIMTANDPWNPALRELRNKTKMVGLNKLGKYPLRRLLKKICQAEKIICDDEALNYIIDTSEGDARYAINMLQGIGEGYGKVTLDLVEAMARRKERELDPFETLRDIFWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDVWRAFDALSRASIFLKRAKGGDWDLLSYAYDLMSSGVAAAEIEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEIIKKLAIHSSFNKTLNDTYPFFLIFYKKYDKRLSLNTKEKEYLNSASKS
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: RL11_MANSM
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNARTESLEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGVKSGSGKPNKEKVGKVTLDQVRQIAETKAADMTGATIETKMKSIAGTARSMGLVVEE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RPOZ_PSEU2
Sequence: MARVTVEDCLEHVDNRFELVMLSTKRARQLATGGKEPKLAWENDKPTVMALREIAAGVMDYSVIAEAEIVEDEPLFAAFEDESNEAV
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ATPB_IDIAU
Sequence: MRINPTTSGPGVSTLEKKNLGRIAQIIGPVLDVAFPPGKMPNIYNALVVKGRDTVGQQINVACEVQQLLGNNRVRAVAMSATDGLMRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVHGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTSQRYKELQDIIAILGLDELSEEDRLTVARARKMERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMKLELESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SYH_MYCBO
Sequence: MTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKDLTTGEQVSVSMDSVVAEVISRLAG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_SINMW
Sequence: MRMRITAILAAGLLAGCQNQAFNEIGRAPAMSPIGSGLQYTQTPQLAMYPKQPRHVTNGYSLWNDQQAALFKDARAINIGDILTVDIRIDDKASFENETDRSRKNSSGFNLGASGESQTSDFAWSGDLEYGSNTKTEGDGKTERSEKLRLLVAAVVTGVLENGNLLISGSQEVRVNHELRILNVAGIVRPRDVDADNVISYDRIAEARISYGGRGRLTEVQQPPWGQQLVDLVSPL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: RDH10_XENTR
Sequence: MHIVLEFFLVTFKVLWAFVLAAAKWLVRPKDKSVAGQVCLITGAGSGLGRLFALEFARRRAQLVLWDINSQSNEETAEMVRSIYRELEAEDSARRAGNATEEEVQPCCNFQVYTYTCDVGKRESVYSTAERVRREVGDVYLLLNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPKMMEMNHGHIVSVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAADKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMRAILTDQPMICTPRLMYIVTCMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
What is the function of this protein?
Retinol dehydrogenase with a clear preference for NADP.  Converts all-trans-retinol to all-trans-retinal.  Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity).
What are the official names of this protein?
Retinol dehydrogenase 10.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: ENO_PSEF5
Sequence: MAKIVDIKGREVLDSRGNPTVEADVLLDNGIIGSACAPSGASTGSREALELRDGDKSRYLGKGVLKAVANINGPIRDLLLGKDPIDQKALDQAMIKLDGTENKATLGANAILAVSLAAAKAAAQDQDLPLYAHIANLNGTPGVYSMPVPMMNIINGGEHADNNVDIQEFMVQPVGAKSFSEGLRMGTEIFHHLKAVLKARGLNTAVGDEGGFAPNLASNEDALKVISEAVANAGYTLGTDVTLALDCAASEFYEDGKYNLSGEGQVFTAEGFAEYLKGLTQRYPIISIEDGLDESDWAGWKILTDKIGEKVQLVGDDLFVTNTKILKEGIDKKIANSILIKFNQIGTLTETLEAIQMAKAAGYTAVISHRSGETEDSTIADLAVGTSAGQIKTGSLCRSDRVSKYNQLLRIEEQLNGKAKYNGRGEFRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DNLJ_BURA4
Sequence: MARTQAEPPASQPDARAAWLRDQLERANYAYYVLDQPDLPDAEYDRLFGELQQLETDHPDLVTPDSPTQRVGGEVAGGFTPVVHDAPMLSLNNGFADEDIAAFDKRVADALGKTTDLAGSVTDPVEYACELKFDGLAISLRYEHGVFVQASTRGDGTTGEDVTENVRTIRSIPLKLKGAHVPALLDVRGEVLMFKRDFARLNERQRAAEQREFANPRNAAAGSLRQLDPKITAQRPLSFFAYGIGVLDGMPMPDTHSALLDWYESFGLPVNRERAVVYGADGLLGFFRKVGEKRESLPYDIDGVVYKVNRRDEQDRLGFVSRAPRFALAHKFPAQEALTRLVAIDVQVGRTGAITPVARLEPVFVGGATVTNATLHNEDEVRRKDIRIGDTVIVRRAGDVIPEVVGALLERRPDDAAEFVMPTECPVCGSKIERLPDEAIARCTGGLFCPAQRKQALWHFAQRRALDIDGLGEKIIDQLVELNLVRTPADLFNLGFATLAELDRFAEKSAQNLLDSLEKAKHTTLARFIYGLGIRHVGESTAKDLAKHFGSLTPIMDASIEELLEVNDVGPIVAESIHQFFAEEHNRTVIEQLRAPGKVTWPEGPPAPKAPQGVLAGKTVVLTGTLPNLTRDAAKEMLEAAGAKVAGSVSKKTDYVVAGADAGSKLAKAEELGIPVLDEDGLHQLLEGNTP
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: 6PGL_YERPS
Sequence: MKQAVYVASPDSQQIHVWQLDSAGELTLLQTVDVPGQVQPMAISPNQRHLYVGVRPDFGIVSYHIADDGTLTAAGMAPLPGSPTHIDTDRQGRFLFSASYSFNCVSISPIDTHGVVQAPIQQLDDLPAPHSANIDPTNQILLVPCLKEDKVRLFDLSAEGQLTPHAQADITVAAGAGPRHMAFHPNHQVAYCVNELNSSVDVYQISNNGQEYHLVQSLDAMPADFTGTRWAADIHITPNGRYLYISDRTANLLGIFTVSKDGRVISLVGHHLTEAQPRGFNIDHSGNFLIASGQKSDHIEVYRIDQNTGELTTLKRYPVGKGPMWVSIRGAQNS
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: RL22_ONYPE
Sequence: METQNAKAIARKISIAPRKARLVVDLIRGKNIAQAQAILTFTPKVAAPVILKLLNSAVSNAVNNLKLNREQLYVKEVFVNEGLRLKRMFPRAKGSGDMIKKRTSHITLVITSSTNLQTSKEEEQSGSKN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HRCA_MYCSK
Sequence: MGSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLDDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVDQRIVELGDAIDEHELATLRDLLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLLGGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVVTTAYGSSGKVYGGMGVVGPTRMDYPGTIANVAAVALYIGEVLGTR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: YWCC_BACSU
Sequence: MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGYSKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELLYSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDACIDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSESEEHQ
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YwcC.
Protein: NSE1_MOUSE
Sequence: MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYQVHDRNATVDKLEDFINNINSVLESLYIEIKKGVTEDDGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDSVKMCNICHGLLIQGQSCETCGIRMHLPCVAKYFQSIPEPHCPHCNDYWPHDIPEVYNPEKEREAGISKSSRKSLRTRQH
What is the function of this protein?
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate.  Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex.  Involved in maintenance of genome integrity, DNA damage response and DNA repair.  NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair.
What are the official names of this protein?
Non-structural maintenance of chromosomes element 1 homolog, Non-SMC element 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSE1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: ATP6_LATCH
Sequence: MSLNFFDQFMSPTLLGVPLIAVAMMFPWTLLPTPTNRWLNNRTLTLQNWFIGRFTNQLLQPLNTGGHKWAMILMSLNLLGLLPYTFTPTTQLSLNMGLAIPFWLATVLLGLRNQPTAALGHLLPEGTPTLLIPILIIIETISLLIRPFALGVRLTANLTAGHLLMQLIATAAFVLLPMMPTVALLTTLVLFLLTLLEIAVAMIQAYVFVLLLSLYLQENV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TSR3_METTH
Sequence: MKIVVYHAEECDRKKCTSLKLGRKGKFKIVSSLNQLPRGALVLNPFSEKAVSPEDRDMVLRRGIAALDCSWKKVKKSSVIFQTARNHRSLPFLVAANPTNYGKPCILSTAEAVAATLYIVGLKDIASDIMSYFKWGPHFLDLNRELLEAYSRAENSLEVVEIQKKFIGG
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RA51D_BOVIN
Sequence: MGVLRAGLCPGLTQDMVQLLQSRGIKTVVDLVCADLEEVAQKCGLSYKALVALRRVLLAQFSAFPFNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGAPGSGKTQVCLCVAAHVAHGLQQNVLYIDSNGGLTASRILQLLQARTPDEEEQAGALQRIQVVRAFDIFQMLDVLQDLRGAVSQQVSSSSGTLKVVVVDSVAAVVAPLLGGQQREGLALMMQLARELKTLARDLSVAVLVTNHMTRDRDSGQLKPALGRSWSFVPSTRLLLDSTQSSGSLGSWRVVCLTKSPRLPTGCQETVDLGSLGTPAFQGDHKGH
What is the function of this protein?
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.  Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity.  Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway.  Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment.  BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks.  The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.  Involved in telomere maintenance.  The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity).
What are the official names of this protein?
DNA repair protein RAD51 homolog 4, R51H3, RAD51 homolog D, RAD51-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CTRB2_HUMAN
Sequence: MAFLWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSRTCSTTTPAVYARVAKLIPWVQKILAAN
What are the official names of this protein?
Chymotrypsinogen B2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TP7_TOBAC
Sequence: MAEKSKVLIIGGTGYIGKFVVEASAKSGHPTFALVRESTLSDPVKSKIVENFKNLGVTILHGDLYDHESLVKAIKQVDVVISTMGMMQLGDQVKLIAAIKEAGNIKRFFPSEFGMDVDKTNAVEPAKSAFAVKVQIRRAIEAEGIPYTYVSCNCFAGYFLPTMVQPGATVPPRDKVIIPGDGNVKAVFNEEHDIGTYTIKAVDDPRTLNKTLYIKPPKNTLSFNELVAMWEKMIGKTLEKIYIPEEQILKDIETSPMPLPVILAINHATFVKGDQTNFKIEPSFGVEASELYPDVKYTTVEDYLGHFV
What is the function of this protein?
Oxidoreductase involved in lignan biosynthesis.  Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers.  Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC), and dihydrodehydrodiconiferyl alcohol (DDDC) to tetrahydrodehydrodiconiferyl alcohol (TDDC).
What are the official names of this protein?
Phenylcoumaran benzylic ether reductase TP7, NtPCBER, Protein TOBACCO PETAL 7.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: DGKH_MESAU
Sequence: MAGAGYQHHPPGGAAVGTSAVSPTAAGPGEDSSDSEAEQGGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKAMVHTACKDLYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKASLLPEPPEASGGFYMTIYEDSVANHLTKILNSDEHAVVISSAKILCETVKDFVAKVEKAQDKTLENTVVAEAVANKCSVLNEKLEQLLQALHADAQASRVPPGVGPAIPEEDAVESSSEESLGESKDQLVNDIAKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDEQTVQPCEPVSPSCDYDSPEADDSKDNDTKESPAAKSTSQAPEAQAIRGHFQTDSVAGSAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTNLYIHPAADLATEEVSQMRLCSQAAEELITRICDAATIHCLLGAGTGSSVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSSALHSVEVELQKLTEIPWLYYILRPNEDEEPPMDCTKRNSKSTVFRIVPKFKMEKAQKQKTSSQPGPGDTESGSYEANSPGN
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8702685).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).  Plays a key role in promoting cell growth (By similarity).  Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF.  Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).
What are the official names of this protein?
Diacylglycerol kinase eta, DAG kinase eta, 130 kDa diacylglycerol kinase, Diglyceride kinase eta, DGK-eta.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli.