PharMolix/UniProtQA huggingface dataset:
Protein: NU3M_ONCNE
Sequence: MNLVTTIITITITLSAVLATISFWLPQISPDAEKLSPYECGFDPLGSARLPFSLRFFLIAILFLLFDLEIALLLPLPWGDQLNAPTLTLLWSTAVLALLTLGLIYEWTQGGLEWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: HEMA_INCKY
Sequence: EKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNPNFPRSADVSVKTANKFRSLTGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAIDCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAGNCNNSFLKNPALYTQKVTPPXXKCGKENLAFFTLPTQFGTYECRLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNSGDTPTMQCDMIQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKDRKSDYAVDQACLSTPGCMLIQKQKPYTGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEISPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK
What is the function of this protein?
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.  Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase.  This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity).
What are the official names of this protein?
Hemagglutinin-esterase-fusion glycoprotein, HEF.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: KUP2_SINMW
Sequence: MADSLDHAPAQANNLPQFLAMTIGAIGVVYGDIGTSPLYAFREALRPFGPDGVERAEVVGLISLMLWTLTIIVTFKYVLFLLRADNDGEGGTLSLLALLMKKAPRYTTLMFMAGILGAALFIGDAMITPALSVLSAVEGLKLVTPAFHDYVLPISVGIMVLLFAVQSRGTGAVSIFFGPITLIWFLVLGAAGVAHIGDDLAILAAFNPVNAVTFLWNAGFVGFIVLGAVFLTVTGAEALYADLGHFGRGPIQAAWFAVVFPALTLNYLGQGALVLSHPEAVSDPFFLMFPNWALLPVVLLATAATIIASQAVITGAFSLVRQAINLGFLPRFEICFTSETQTGQIYLPFVNNALLAGVIVLMFMFGSSESLATAYGISVTGAMVVTTVLAFEFARHQWGWSTLTATAVLLPLLVLELFFLGANLFKIHDGGYVPILIAGTLMTTMWTWRKGVSLLREKTARQDIPLSQFMAMVERKSEHAPVEVPGTAIFLTATPDTTPAVLLHNIKHNHVLHQHNVILTIKTARVPYVPEKDRYTIEKLSDRFSLLELRFGFMDDQNVSRALARCRKEGFKFEIMSTSFYLGRRKLIAAPQSGLPQWQDKLFIAMADSAIDPTEYFHLPPNRVVELGEQVVI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YQGF_TROWT
Sequence: MVKSVADRFFLGLDFGSTRIGVARNCGSLAVPVGVLPRASCAEILGYISRYSIDEVVIGLPLTLAGKEKQSARLAKEFSRFLVSSGVQVRFFDERFTTVIATQKFYSLGKGVKQIRKCVDAAAATVMLQLFLDMEVKVDPLERKP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_SULIK
Sequence: MVELLGIIRIRGWAKAPWYINETLEMLRLRYNFNTMMYPKTSQILGMLNKVSPYVTWGEIDPDTLKLLIIKRLETAKGDKVSDSYVKEVLKIENIDTMVKQLYEGKIYLHKLDQYFKLPIRLHPPKGGFKGSVKRPYKNKGEFGYRGDKINELMRRMM
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TPIS_ACTP2
Sequence: MARRPLVMGNWKLNGSKAFTKELIAGLKAELADVKGCDVAIAPPVMYLAEAEAALAGQSVIALGAQNVDVNVQGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKECDTFIAKKFAALKAAGLVPVLCIGETEAENEAGQTEAVCAKQIDAVIDALGVEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAAKSQAVADQVIIQYGGSVNDANAAELFTQPDIDGALVGGASLKAPAFAVIVKAAEKAKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQD_ACIB5
Sequence: MNKEQFDVNLVPTWRQGYRFQFEPAQNGFVILYPEGMIKLNESAGAIGQYIDGTNNVSAIIAQLKQQFGDIPEIDNDVIDYMLVAQQQHWIDLV
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: AROC_AGRVS
Sequence: MSHNSFGHLFRVTTWGESHGPALGAVVDGCPPGLKFTLEDLQVWLDKRKPGQSRFVTQRREDDLVKVLSGVMPQDDGSMITTGTPISLMIENTDQRSKDYGEIAQQYRPGHADYTYDLKYGIRDYRGGGRSSARETAARVAAGGIARLVLPGVTIRGALVQIGTHKIDRANWDWSEVDNNPFFAPDPKIVPVWEDYLDQIRKQGSSVGAVVEVVAEGVPAGLGAPIYAKLDQDITALLMSINAVKGVEIGNGFGAAEITGEENADQMRMGNDGQPIFLSNHAGGILGGISTGEPIVARFAIKPTSSILTERQSIDSQGRNVDIRTKGRHDPCVGIRAVPVGEAMVACALADHYLRDRGQTGRLK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: TAF11_ARATH
Sequence: MKHSKDPFEAAIEEEQEESPPESPVGGGGGGDGSEDGRIEIDQTQDEDERPVDVRRPMKKAKTSVVVTEAKNKDKDEDDEEEEENMDVELTKYPTSSDPAKMAKMQTILSQFTEDQMSRYESFRRSALQRPQMKKLLIGVTGSQKIGMPMIIVACGIAKMFVGELVETARVVMAERKESGPIRPCHIRESYRRLKLEGKVPKRSVPRLFR
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 11, TBP-associated factor 11, AtTAF11.
What is the protein family that this protein belongs to?
Belongs to the TAF11 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURC_STRP2
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_VIBA3
Sequence: MTQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGRGCNVTAPFKEDAYQFANRLTERAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVTLKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKAELLAEMFSSHGNIKGIGLSDVNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: YIDD_NITWN
Sequence: MKTIPSEVRCSRLCPACTNAALRLPRNAGRALIWIYRHTLSPLVGFNCRHLPTCSAYGDEAIARFGLWGGGWMTLARILRCRPWGTSGIDNVPVAKPSGATWYRPWRYGRWRGVNAK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GGYF2_DANRE
Sequence: MAETQTLNFGPEWLRALAGGVGSSIVASPPLSPALPKYKLADYRYGREEMLALYVKDNMIPVDLHDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGTVAGAPRGRSSSRGRGRGRGDGFYQRSFDDVEGGFGRGGREMHRSQSWEERGDRRFEKPGRKDPDGAPAHFPLNHIRANYEDPAAVNARKFIHAECDNWRTTRDELNGEEDDNGWRLAGARRENERWCPPSPDGPRSAGWREHPDQRRRFGFGDEERSGYRRPRSGSGSAEEERDSLPEWCLEDAEEETGTFDSSGAFLSLKVRALEKAPKEPILEEAELDFRPLEENDEYAEKDDSETEQTKDTDTNTRHESDRNEENCKSEEPSPVAVPFSAVVTPPKATTPAPIQPVHLEKAEDKERPSERTTLPEIRHELSKAPLHTALSNSIVEAISIPHVANKLPDLPVPAPSVLPVKSVPPQSQQVKPIEMPVSVPPALLRSTGSVGPISRPSALPSDLDEDEGLKHFEQEAEKMVAYLQDGGVDDERLASKIGPKPSALPITNEAAFKWFYKDPQGEIQGPFNNQEMSEWFQAGYFTMTLQVKRGCDEMFQPLGEMIKLWGRVPFTPGPTLPPILGDADQERMKRQQEINALNMYQLQQMQYQYLLRQQYALQQKVLNSAPPPPPPPQQQLNLLLHQALKIRTPEPQQSLLPPVTRSMSVPDSGSVWEMQNPSTQASCSPNMQPAAPSTWEGSSVWDLPLDNMPQASSIEQLQLEKAKALKLEMERREAELRAKREEEERKRLEEALRARQEEERKRLEEEELARRKQEEALKRQREQEEAQRRKKEEEERLAQEEALRRLEERRREEEERRQREEFLRKQQEEERRKQEELEAQRRREEEKRLEEEAAAAAAALLRQQQEEQKKREQEAQRQQELQRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSKWGQQSTTANSLSQSQNALSLAEIQKLEEERERQTREEQRRQQQELQRVQQQQPQTKLPGWGSVAKQPMATKSLLEIQREEAQQMKQRKDQQQQQQQQQQPPPQPQPQQHSTNTQQNRTQNRAAINTSVWGSVNNVSSNWMMDSSVWGDTQNSNIGFWDEAVKEAAPPQTTRKSHTPKNKGNANLSNSSSGKASKKVEEEEKLLKLFQGANKNQDGFMQWCEQTLHTLNTANNLDVPTFASFLKEVDSPYEVHDYVRAYLGDTPQAKDFAKQFLERRAKQNDNQQKPQQGQQQKQQESVWGIREVPQSVLLQQQQQQQLQQQQQQRFETVTSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVEDF
What is the function of this protein?
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.
What are the official names of this protein?
GRB10-interacting GYF protein 2, PERQ amino acid-rich with GYF domain-containing protein 2, Trinucleotide repeat-containing gene 15 protein.
What is the protein family that this protein belongs to?
Belongs to the GIGYF family.
Protein: RL13_HELAH
Sequence: MTKTAKVSDIVRDWVVLDAKDKVFGRLITEIAVLLRGKHRPFYTPNVDCGDFVVVINANKVKFSGMKLEDKEYFTHSGYFGSTKSKTLQEMLEKTPEKLYHLAVRGMLPKTKLGKAMIKKLKVYRDDKHPHTAQTSKKDAK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NRDR_STRP1
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MRG2_ARATH
Sequence: MGSPNAAAETDLTTDDFIGDTRRDSGSDTETNTDCDGEDLPLLLLPAPPGHFEEGERVLAKHSDCFYEAKVLKVEFKDNEWKYFVHYIGWNKSWDEWIRLDCLLKHSDENIEKQKEQGLKQQGIKSAMAWKVSKMKPRSPNVARGRKRKQDSVDTEKNVLPSDNLLSFNIPPALRKQLLDDFEFVTQMQKLVQLPRSPNVDGILKKYIDSQMKKHGRVTDSLEEILKGLRCYFDKALPVMLLYNNERKQYEESVSGGVSPSTVYGAEHLLRLFVKLPELLVHVNMAEETLKELQDNFVDILRFLRKNQSVLFVSTYKAVEEMEKKEG
What is the function of this protein?
Chromatin remodeling factor.  Acts as a 'reader' protein by binding to H3K4me3 and H3K36me3 to control histone H4 acetylation.  Increases the transcriptional levels of the flowering time genes FLC and FT (PubMed:25183522, PubMed:25211338).  Binds the chromatin at the FT promoter upon interaction with CO (PubMed:25211338).
What are the official names of this protein?
Protein MRG2, MRG family protein 2, Morf Related Gene 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMP_LACCB
Sequence: MSTQSVVETVTALVKPILDDHHFYLTDVEFVKEGGGWYLRVYIDKTGGITLDECVMVSEALSEKLDAMDPDPIPQQYFLEVSSPGAERPLKHETDYEQAVGDYIHVSLFKKLDGKKVFEGTLKELLPDQLTLTVKDKSRKFDQVIDRQLIASARLAIEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA3_BOVIN
Sequence: MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMDPAQYPLPEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSGRQDEKECIKYQVPLPDSMKLESAHPRGSMATLGGAAASAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG
What is the function of this protein?
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes.  Binds to the consensus sequence 5'-AGATAG-3'.  Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity).  Positively regulates ASB2 expression (By similarity).  Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33.  Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
What are the official names of this protein?
Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRVB3_MACMG
Sequence: TFFKSNDDVKKAFFVIDQDKSGFIEEDELKLFLQNFSAGARALTAGETKTFLAAGDSDGDGMIGVDEFQALVKA
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 3.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: KTHY_ALTMD
Sequence: MRGKFIVVEGLEGAGKSSVIGLIVKALTDAGMRVEQTREPGGTPMAEAIRECVKHDWDETVSEETELLLMYAARVQLLTNKIYPSLNAGAWVVGDRHDLSSQAYQGGGRGVSEKTMTAISDIALNGFKPDLTLYLDVDPAVGLERARGRGELDRIEQAGLGFFERTRARYLSLAENDESIIVVNAMQPMEQVHQDVISIIANYVSQHIDEGSESHKTDQGNN
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: VHAA3_ARATH
Sequence: MAESGGGGGCCPPMDLMRSETMQLVQLIVPMESAHLTVSYLGDLGLVQFKDLNSEKSPFQRTYAAQIKRCGEMARKIRFFRDQMSKAGVPAKEMQGKENDIDLDDVEVKLGELEAELVEINANNDKLQRSYNELMEYKLVLQKAGEFFSSAHRSAADQQRETESQQAGEDLLESPLLQEEKSIDSTKQVKLGFLTGLVPREKSMVFERILFRATRGNIFIRQTVIEEPVIDPNSGEKAEKNVFVVFYSGERAKSKILKICEAFGANRYPFSEDLGRQAQMITEVSGRLSELKTTIDAGLGQRNILLQTIGDKFELWNLKVRKEKAIYHTLNMLSLDVTKKCLVAEGWSPVFASREIQDALQRAAVDSNSQVGSIFQVLRTKESPPTYFRTNKFTSAIQEIVDAYGVAKYQEANPGVFTIVTFPFLFAVMFGDWGHGICILLATMYLILKEKKLASQKLGDIMEMAFGGRYVILMMSLFSIYTGLIYNEFFSIPFPLFAPSAYDCRDVSCSEATTIGLIKVRDTYPFGLDPVWHGSRSELPFLNSLKMKMSILLGVSQMNLGIIMSYFNARFFKSSVNIWFQFIPQMIFLNSLFGYLSVLIIIKWCTGSQADLYHVMIYMFLSPMDELGENQLFPHQKTLQLVLLFLALVSVPCMLLPKPFILKKQHEARHQGQAYAPLDETDESLHVETNGGGSHGHEEFEFSEIFVHQLIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFYEKVLLLAWGYNNPLILIVGVLVFIFATVGVLLVMETLSAFLHALRLHWVEFQNKFYEGDGYKFAPFTFIFTANEDE
What is the function of this protein?
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes.  Required for assembly and activity of the V-ATPase.  Involved in vacuolar nutrient storage (e. g.  accumulation and storage of nitrate) and in tolerance to some toxic ions (e. g.  zinc ions sequestration in vacuoles).
What are the official names of this protein?
V-type proton ATPase subunit a3, V-ATPase subunit a3, V-type proton ATPase 95 kDa subunit a isoform 3, V-ATPase 95 kDa isoform a3, Vacuolar H(+)-ATPase subunit a isoform 3, Vacuolar proton pump subunit a3, Vacuolar proton translocating ATPase 95 kDa subunit a isoform 3.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase 116 kDa subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: SMAL1_HUMAN
Sequence: MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFDNWDSFTSPL
What is the function of this protein?
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA.  Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA).  Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA.  May play an important role in DNA damage response by acting at stalled replication forks.
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein, hHARP, Sucrose nonfermenting protein 2-like 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
Protein: NSRP1_BOVIN
Sequence: MAIPGRQYGLILPKKAQQLHPVLQKPSVFGNDSDDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDSTVYEYDSIYDEMQKKKEESNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEERERRAAALEARLDVTKQRDLSGFYRHLLNQAVGEEEVPTCSFREARSEIKEEKSKGYSDEVSSESRIPPENCIRQTGVKVEENPDADSDFDAKSSENDEMEGDKGNCRREKGTETLSSHSKHHRNPARSPSSSEEREHGTQCHTKSSRSRGHEKREDEHQERPAREQDSYHTDRDSRKEKRDSHRHRESSHRDSHWKRHEEERLRGRDERERNDREWKREKDREKYPSREQERHRQRNNYDRHNEKGCEKEEKSKEKEEHVKARKERYENSDKYRDREKREVSVESSERNRDRKESSPNSRAKDRFVNQERASKMRDMEKDKERNPEKPSSSEASLGAKHRITEECQETGKEQERLHETVNKFAKRSNEETVTSARDRYLARQMARINAKTYIEKEDD
What is the function of this protein?
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
What are the official names of this protein?
Nuclear speckle splicing regulatory protein 1, Coiled-coil domain-containing protein 55, Nuclear speckle-related protein 70, NSrp70.
What is the protein family that this protein belongs to?
Belongs to the NSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.
Protein: RUVB_LACCB
Sequence: MADADKDRLVSGDVDDSNEAQIEKSLRPRMLAQYIGQDRVKHQLEVYITAAKQREESLDHVLLYGPPGLGKTTLALVIANELGVNIRTTSGPAIEKPGDLVALLNELHPGDVLFIDEIHRLPKIVEEMLYSAMEDFYIDIVVGQGPTAHPVHFPLPPFTLIGATTRAGMLSAPLRDRFGISEHMAYYSADDLSEIVKRSATIFDMAIDAEGAHEIARRSRGTPRVANRLLKRIRDFAEVAGQSPVDIQMVDHALDQLQVDQQGLDQIDRKLLMFMIRDYEGGPVGLSTIAANIGEEMATIEEMYEPYLLQIGYLKRTPRGRMVTPAGFAHMGMSAEQH
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NU4C_ORYNI
Sequence: MSSFPWLTILVVLPIFAGSLIFFLPHRGNKIVRWYTMSICLLEFLLMTYAFCYHFQLEDPLIQLKEDSKWIDVFNFHWRLGIDGLSLGSILLTGFMTTLATLAAWPVTRNSRLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKRRLYSATKFILYTAGGSIFFLIGVLGMGLYGSNEPRLDLERLINQSYPATLEILFYFGFLIAYAVKLPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHYLFSPWLVIIGAMQIIYAASTSLGQRNFKKRIAYSSVSHMGFIIIGIGSITNIGLNGAILQILSHGFIGATLFFLAGTACDRMRLVYLEELGGVSIPMPKIFTMFSSFSMASLALPGMSGFVAELVVFFGLITSPKFLLMPKMLITFVMAIGMILTPIYLLSMLRQMFYGYKLFHVPNENFEDSGPRELFLLICIFLPVIGIGIYPDFVLSLSVDRVEALLSNYYPK
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.