PharMolix/UniProtQA huggingface dataset:
Protein: ERPA_SHESW
Sequence: MTEQADAAMPIQFTDAAAAKVKGLLEEEQNPALKLRVYVTGGGCSGFQYGFTFDEKVNEGDFTVEKQGVQLVVDPMSLQYLVGGEVDYTSGLEGSRFFVKNPNATTTCGCGASFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RNPA_RICAE
Sequence: MSITSLKNQKEFELINKLGKKLHERYFILVIATKLPKIFLESKYNTFLGIKVSRKLNKKAVVRNKIKRRIRHLIRIIVSDSSFKAIKFAMIIIPRKGFEEINFSHLNYELSKVILRNI
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: GLGB_PROMA
Sequence: MSTSINIDWLANEGQKLAECRHDNPLGVLGPQQIENKWALRVWMPEADAVNLLLKDGKKKLTNPNHPWIFETSLEENPGSSYQISVERAGISHTQNDPWAFRHEWMGEIDRHLFAEGNHHHIWRRMGAHQTKLDLVEGVMFCLWAPNARSVSVIGDMNSWDGRHHPMQKRLGGIWELFIPHIKKGDLYKYEIRSQEGHCYEKADPYGFQHEVRPAQSSIVSTLDSYKWKDQKWMTQRDKTDQLNKPISVYEMHLGSWMHSSNKTPYIEKDGSTREPVPAADLKPETRFLTYPELTEKLIPYVKARGFTHIELMPISEHPFDGSWGYQVTGWYAPTSRYGTPDEFRAFVDTCHSEGIGVILDWVPGHFPKDEHGLAFFDGKHLYEHADPRIGEHKEWGTLIFNYSRNEVRNFLVANLVYWFEQFHIDGIRVDAVASMLYKDYLRPEGEWIPNEDGGNENFEAVNFLQQANHVLFQHFPGALSIAEESTTWSGVTKPTDMGGLGFNLKWNMGWMHDMLDYFEIDPWFRQFHQNNVTFSICYNYTENFMLSLSHDEVVHGKSHLLHKMPGDDWKKYANTRALLAYMWTHPGKKTLFMGMEFGQRQEWNVWDDLQWELLEHDPHKGIQLLIDDLNCLYKSQPALWKDDFNEYGFQWIDCKDNTNSVISFMRRESSTGEWLVVVANFTPETHANYKVGVPVSGYYAEIFNTDAKKYGGSNTGNLGGKYSTEWNIHEYENALELSLPPLSVLILKYRKNKK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: SG112_DROGR
Sequence: MANSNTNQLHPLGATTSQTFITALNHTAASTIAINFRELIKEPKELDEASNYLYQALLDDVVAGIFIETHHLRKTGNLAALDGVGEENLESAFHICEMPNLDIFGISTAKKQMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGSSASTSSTSTYLQSGGNTGGTDDEDDVDWSSDKRKKKSTQSSRNNGSKKNNGKTF
What is the function of this protein?
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Binds independently on SAGA to promoters in an RNA-dependent manner.  Binds to mRNA and is essential for total mRNA export from the nucleus.  Required to counteract heterochromatin silencing.  Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe.  Required for expression of ecdysone-induced genes such as br/broad.
What are the official names of this protein?
SAGA-associated factor 11 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: FUMC_BORPE
Sequence: MKTRTEKDTFGPIEVPEQHLWGAQTQRSLHFFAISTEKMPVPLVAAMARLKRAAAKVNAELGELDPQVADAIMRAADEVIAGKWPDEFPLSVWQTGSGTQSNMNMNEVLANRASELLGGERGEGRKVHPNDHVNRGQSSNDTFPTAMHVAAAVEVEHRVLPALKALRGTLAAKSAAFYDIVKIGRTHLQDATPLTLGQEISGYVAQLDLAEQQIRATLAGLHQLAIGGTAVGTGLNAHPQFSAKVSAELAHDTGSAFVSAPNKFQALASHEALLFAHGALKTLAAGLMKIANDVRWLASGPRSGLGEISIPENEPGSSIMPGKVNPTQCEAVTMLAAQVMGNDVAINVGGASGNFELNVFKPLVIHNFLQSVRLLADGMVSFDKHCAAGIEPNRERITELVERSLMLVTALNPHIGYDKAAQIAKKAHKENLSLKEAALALGHLTEAQFAEWVVPGDMTNARR
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F131B_RAT
Sequence: MDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKAPAIQPQHSHEAVRRDTDAYSDLSDGEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLDCNYSDNYQELMESQDALAQAPMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHDMGPSQPASGYSAQEPPPLLGVDTDWASEVGGVELARGPVEEEKRPLAPEEEEDAGCRDLESLSPREDPEMSTALSRKVSDVTSSGVQSFDEEEGDANN
What are the official names of this protein?
Protein FAM131B.
What is the protein family that this protein belongs to?
Belongs to the FAM131 family.
Protein: YM158_YEAST
Sequence: MHHFVPSISLFMASVSFSVFFSHLATSWECSFFRSESFCCKTLFSMVPLINSSFNLSVFLFFNAITSFNLRISCSLLFSSFCRIASVFNKASSWLTMLPPMAPLLS
What are the official names of this protein?
Putative uncharacterized protein YMR158W-B.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DNAJ_BACAA
Sequence: MSKRDYYEVLGLSKGASKDEIKKAYRRLAKKYHPDVSKEENAIEKFKEVQEAYEVLSDDQKRAQYDQFGHAGANQGFGGFGGGGDFGGGFGFEDIFSSFFGGGGGRRRDPNAPRQGADLQYQVTLEFEEAIFGKELNVEIPVEDPCDTCKGSGAKPGTSKETCKHCSGSGQVSVEQNTPFGRIVNRQACSHCSGTGQMIKEKCTTCHGSGKVRKRKKINVKIPAGIDNGQQIRVSGKGEAGVNGGPAGDLYVVVHVRSHEFFEREGDHIICEMPLTFAQMALGAEVEVPTVHGKVKLKIPAGTQTGTEFRLKGKGAPNVRGYGQGDQYVVVRVVVPTKLTSHQKDLLREFAGQEEQDDSLFGKLKRAFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_PASMU
Sequence: MEVIMNSSIVKLPNKYELVKDTLVLILAGGRGSRLYELTDKRAKPALYFGGNRRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERGEFIDMLPARQQIDDSTWYRGTADAVYQNMAIIRDHYCPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEVEREKATEFGVMAVNENLKVKSFVEKPKDPPAMVGKPNTSLASMGIYVFDADYLYDVLEREVSSPYTSHDFGKDILPKALEEGVLYAHPFSRSCMGRNTEGEIYWRDVGTLDSFWQSNIDLVCENPQLDIYDQSWPIRGNPVQTYPSKFFYKKENARPVDNSLISGGCVITDASISYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLELDRQRFRVSSGGVVLVTPSMLKKLNGEEVASEAHLD
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MATK_VICVI
Sequence: MQVYLERARSRQQDFLYPLLFREYIYGLAYSHHLNRSIFVENVGYDNKYSLLIVKRLITRMYQQNHFIISANDSNKNAFWGYNKNFYSQIISEGFAIVVEIPFFLQLSSSLEEAEIIQYYKNLRSIHSIFPFLEDKMTYLNYVSDIRIPYPMHLEILVQILRYWVKDAPFFHFLRLFLYNFCNWNSFITTKKSISTFSKSNPRFFLFLYNFYVCEYESIFVFLRNKSSHLRLKSFSVFFERIFFYAKREHLVKVFSKDFSYTFTFFKDPYIHYVRYQGKCILASKNAPFLMNKWNHYFLHLWQCFFDVWSQPRMININPLSEHSFQLLGYFSNVRLNRSVVRSQMLQNTFLIEIVIKKLDIIVPIIPLIRSLAKAKFCNVLGQXISKPVWADSSDFDIIDRFLRICRSLSHYYNGSSKKKSLYRIKYILRFSCIKTLACKHKSTVRAFLKRSGSEELLQEFFTEEEDIFSLIFPRDSSTLQRLHRNRIWYLDILFSNDLVHDE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CASQ1_CANLF
Sequence: EEGLDFPEYDGVDRVVNVNAKNYKNVFKKYEVLALLYHEPPXXDKASQRQFDMEEL
What is the function of this protein?
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:14871888).  Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits.  Can bind around 80 Ca(2+) ions.  Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity).  Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
What are the official names of this protein?
Calsequestrin-1, Calsequestrin, skeletal muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the calsequestrin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium.
Protein: PUR5_YERE8
Sequence: MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVAPGDALVALGASGPHSNGYSLVRKILEVSNTDPEQTQLDGKSLADHLLEPTKIYVKSILSLIEQLDIHAIAHLTGGGFWENIPRVLPQGTQAVIDEASWQWPAVFSWLQETGNVSRHEMYRTFNCGVGMVVALPAELADKAVELLTASGEKAWKIGVIAAAAEGAEQVIINP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_AQUAE
Sequence: MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKIFPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_NITEC
Sequence: MVAKILVVHGPNLNLLGRREPSIYGHTTLEDINRNLVAKAQAASVVLDTFQSNAEHELIDRVQEAMNDGTGFIIINPAALTHTSIALRDALAATNLPFVEIHLSNIYAREHFRHTSYFSDIAVGVISGLGAAGYELALQFALARQ
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL35_LEIXX
Sequence: MPKQKTHSGAKKRFKITGSGKVMKQQAGMRHNLEVKGSDRKRRLNADQVVPEVDAKFVRRMLGK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ENTP7_XENTR
Sequence: MARISFSCLFPASWHCSLPSVTQFSRQRVALLIISVAVFILVFAAVADLQLWSSRAFRDRQFRRYLDQIEDLEATDTKDTKLNYGVVVDCGSSGSRVFVYFWPPHNGNPHDLLDIKQMRDRGSKPVVKKIKPGISTMALTPEKSSDYINPLLSFAASYIPKHKHKETPLYILCTAGMRILPESQQIAILQDLVKDVPQEFDFLFSEAHAEVISGKQEGVYAWISINFVLGRFDHVVDEEDAVVAVTIGTQEESIIRKRTVGVIDMGGGSLQIAYEVPTTMTYPSVEHEEVAKSMLAEFNLGCDLQHTEHVYRVYVTTFMGFGGNFARQRYEDMVFNDTITKNRIQGQQIGVHPNSPLQDPCLPVGLIDQVRRQSHDLHVLGKGNWDSCRQQLEPLLLKSNDTQAYLNSVYQPSIDFSNSEFYGFSEFFYCTEDVLRMGGIYNSQKFAKAAKEYCSMPWTTLQDRFNSGLYSSHADQHRLKYQCFKSAWMFSILHNGFHFPHEYPNFKTAQLVYDKEVQWTLGAILYKTRFLPLRDIRQESSRPAHVSWFRISFVYNHYLFFACILVVLLSIVLYILRLRRIHRRQARASALDLLLMEEGVHTVLEPGIPT
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner.  Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP.  Hydrolyzes ATP and nucleoside diphosphates only to a minor extent.
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 7, NTPDase 7.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: NU3M_PETMA
Sequence: MNSFMVMIMLTLTLSSIMALLAFWLPIMKPDSEKLSPYECGFDPQGSARLPFSLRFFLVAILFLLFDLEIALLLPSPWATNISNPEFTLLWASLFVLLLTLGLIYEWLQGGLDWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MUTL_ANAD2
Sequence: MPRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSKLRDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKFMRAASTEAGHVSEAVIRLALARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSPDHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFDALFHTVAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPAPGAGPEAGPRPEGYFAALRYVGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPAAARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSAVDDAFHDLLATMACHAAVRANQDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADLERRVGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: LAMP2_CHICK
Sequence: MAPPRCPAGLALLLLLLGACGFFQSYAVEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYADTPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV
What is the function of this protein?
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live.  Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity).  Plays a role in lysosomal protein degradation in response to starvation (By similarity).  Required for the fusion of autophagosomes with lysosomes during autophagy.  Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes.  Required for normal degradation of the contents of autophagosomes.  Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits.  Is not required for efficient MHCII-mediated presentation of endogenous antigens (By similarity).
What are the official names of this protein?
Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the LAMP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Protein: GLYA_VEREI
Sequence: MYHRHLLVEQTDPELFAAIEAENARQEQHIELIASENYASPAVMWAQGTQLTNKYAEGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMSGKWFNAVSYGLDADEVIDYEAMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNPVPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEALQPGFRLYQEQVLKNAKVLAQTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGAAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQARSTAELIADLLDKPRDAANIAAVRAKVDALTARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUIP_PSEPF
Sequence: MASPALSHFLPRFGVAAAVAGVLSLTGCQTWNAQDTLPPTSGVQPLKGLAQNVSVRRNAMGMPLIESNSFHDALFALGYVHASDRINQMVTLRLLAQGRLAEMSGSSMLDADRYMRAVNLKKSAGELYKASSPRLKRFFEVYARGVNAYLFRYADKLPGDLASSGYKPEYWKPEDSALIFCLLNFSQSANLPEEIASLVLAQTVTNDKLAWLTPSAPDENLPLAEADKLQGIKLNGQIPGLTELSNASEQLAALNLLGTQSSNNWAIAPQRSRSGKSLLASDSHGPLAAPSLWSFVQIRAPKYQAAGVTVAGLPMVLGGFNGKVAWSLTSVLGDNQDLFLEKIRRQGSSLTYEVNGKWQPVAVRNETYFVKGQRPIREAVYETRHGALLNSTQAAAQGTGFGLALQTPSFTDDKSLDAFFDLSRAQNVERASDATREIRAIALNLVFADASNIGWQVTGRFPNRREGEGLLPSPGWEGRYDWDGYADPMLHPYDQDPAQGWLGTANQRVIPHGYGMQLSNSWAAPERGERLAELAGSGKHDSRSVIAMQYDQTTTFAAKLKKMFEAPGMAQPLKQAIDALPEAERSKAREAYTRLMAFDGKLSPTSADAAIYELFLQESMKQIFLDELGPQNSPAWKAFIANGDLSYAAQADHLLGREDSPFWDDARTPQKEDKPAILARSLAAAISAGDSQLGGDRRAWQWGKLHRYEWKNANGQSVRGPIAAGGDHTTLNTAAFAWGQDFNTTRAPSMRFIVDFGQSEPLMGQNGTGQSGNPVSPNYLNGIDPWLKGQYIGLPMQPQNFDRVYGKTRLTLTPGK
What is the function of this protein?
Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid.  Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of seven or more carbons in length) (By similarity).
What are the official names of this protein?
Acyl-homoserine lactone acylase QuiP, AHL acylase QuiP, Acyl-HSL acylase QuiP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S45 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL36_BACC4
Sequence: MKVRPSVKPICEKCKVIRRRGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: TRPC_BRUSI
Sequence: MSTDILRKIEAYKREEIAAAKARVALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAEIKKASPSKGLIRPDFDPPALAKAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPALRKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDTAFALGMDALIEVHDEAEMERALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIGTFLIGESLMRQHDVAAATRALLTGAEKL
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: STAT_DROME
Sequence: MSLWKRISSHVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNENGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNGDFGMADFDTITNFENF
What is the function of this protein?
Might play a role in signal transduction and activation of transcription.  Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression in early development as part of the Janus kinase-STAT pathway (PubMed:8608595).  Might play a role in male germline stem cell maintenance (PubMed:34644293).
What are the official names of this protein?
Signal transducer and transcription activator, d-STAT, Protein marelle.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein: DHOM_METGL
Sequence: MKPINVGLLGIGTVGGGTYTVLTRNQEGNRAPCRPPNCHHARRDRNLELARKVTGGQIDVTDDAFAVVVRPRHRHRGRIDRRIHHRARTGYEGDRERQARVAANKALMLAWQRDFRRVAQQKGVIVAFEAAVAGGIPIIKAVAAGAGRQPSSRVLRAIINGTTNFILSEMREKGLAFADVLKEAQPRLCEATRPSTSRAWTAHKLMILAAIGFGIPMQFDKAYVEGISKLDALDIRYAEELGYRQAAWHAPSAPARGVELARAPDPDPRETPDRQCQRRHNAVLVSDACRSHLVYRPDACRRHASAVVADIVDGTRTAYHRRAPAVPHLLSSPTSSWTCRFAIGEVSSAYYLRLRAVDKPGRDGHVTRILATGSLHRCDDSEGNRRQAERRRSGRHHHPDHVTVEKNMDDAIVAIEALPAISGSVTRLRMEELSR
What are the official names of this protein?
Homoserine dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the homoserine dehydrogenase family.