PharMolix/UniProtQA huggingface dataset:
Protein: RL5_RICTY
Sequence: MLRFKELYKKKIIESLKKEFSFKNQHEIPQIKKIVINMGVGEAIADSKVINNALNDLTLISGQKPIVTLARKSIATFKLRENMKIGCKVTLRKDRMYDFLERLVIVALPRVKEFRGFSYKSFDGKGNFTFGLKEQIVFPEINYDKIDTIRGMDITIVTSAKTDQESKFLLSGFNLPFYN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ATPD_BACC7
Sequence: MSNGIVAKRYAVALFKIAKEKHVLEMFEEELRLVQNVYVKNGELHSFLTQPNISKEQKKTFLANVFGSVSESILNTLYILIDNKRIDILPEIADEYVVLANEERNVADATVYSTRLLSEEEKLNIAEAFAKRTGKDAIRVKNVVDEDLLGGIKVRIGNRIYDGSLQGKLARIQRELMKNR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CCG1_HUMAN
Sequence: MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKRIPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH
What is the function of this protein?
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle.  Regulates channel inactivation kinetics.
What are the official names of this protein?
Voltage-dependent calcium channel gamma-1 subunit, Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Multi-pass membrane protein.
Protein: ADE_CAMLR
Sequence: MKTFLQNIPKVELHLHIEGSLEPKMMFELAKRNNITLKYKSEDEIKKAYDFSNLQDFLDIYYQGANVLQTKQDFYDLTFAYMKKCKEQNVVHTEIFFDPQTHTARNIPLKDVIEGIWQALQKAKEEFGISSFLIACILRHLSEEEGLKTLDELCLYKDKIKAIGLDSSELNNPPFKFKNLFQKAKEEGFLLVMHAGEEGSSEYIKQALELGVNRIDHGVRCQEDLELVKQLAKSQIPLTICPLSNIKLKVFQNMQEHNILKLLKQNLCVCVNSDDPAYFGGYILENFIALDETFKLSKDEVKKLCINAVNASFLNINEKEKLVKQIKAYK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: RL20_MESFL
Sequence: MARVKFGKVTRARRKRWIKRAKGYYGTKHSSYKKAHEQVVRSMAYAFIGRKQKKRDFRKLWIVRINAAVRPYGLSYSKFMNGLKLANIDVNRKMLSELAISNPEQFKLLVDASNKALTSK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PROB_PSE14
Sequence: MTGAQRWVVKIGSALLTADGKGLDRNAMGVWVEQMAALHEAGVELVLVSSGAVAAGMSRLGWTARPSAMHELQAAAAIGQMGLVQAWESSFAEHGRHTAQILLTHDDLSDRKRYLNARSTLRTLVELGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPEAQLIYEARADDPALDAVAGGTGGALGRGGMQTKLRAARLAARSGAHTVIVGGRIERVLARLKGGERLGTLLSPERGMLAARKQWLAGHLQTRGTLVLDDGAVAALAKDQKSLLPVGVKLVQGSFRRGEMVVCVASDGREIARGLSNYSAIEAQKIIGHSSESIVRELGYMAEPELIHRDNLILV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB2_SCHPO
Sequence: MSYEDYQYNETLTQEDCWTVISSFFEETSLARQQLFSFDEFVQNTMQEIVDDDSTLTLDQYAQHTGAQGDVTRRYEINFGQIYLSRPTMTEADGSTTTMFPQEARLRNLTYSSPLYVDMRKKVMVAADSNVPIGEEEWLVEEEDEEPSKVFIGKIPIMLRSTFCILNGVSDSELYDLNECPYDQGGYFIINGSEKVIIAQERSAANIVQVFKKAAPSPIAYVAEIRSALERGSRLISSMQIKLMARNTENSGQTIRATLPYIRSDIPIVIVFRALGVVPDRDILEHICYDPNDFQMLEMMKPCIEEAFVIQDKDIALDYIGKRGSTTGVTREKRLRYAHDILQKELLPHITTMEGFETRKAFFLGYMIHRMLLCALERREPDDRDHFGKKRLDLAGPLLASLFRMLFRKMTRDVYKYMQKCVETNREFNLTLAVKSNIITNGLRYSLATGNWGDQKRSMVNRVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMSYVSVGSPSAPIIEFLEEWGLETLEDYNPSASPNATKVFVNGVWLGVHRDPAHLTETLRSLRRRLDISAEVSIVRDIREKELRLFTDAGRICRPLFIVDNNPNSERRGELCIRKEHIQQLIEDKDRYDIDPEQRFGWTALVSSGLIEYLDAEEEETVMIAMSPEDLEASRQMQAGYEVKEELDPAQRVKPAPNPHVHAWTHCEIHPAMILGILASIIPFPDHNQSPRNTYQSAMGKQAMGVYLTNYQVRMDTMANILYYPQKPLATTRSMEYLKFRELPAGQNAIVAILCYSGYNQEDSIIMNQASIDRGLFRSIFYRTYTDQEKKIGMTVMEEFERPVRSTTLRMKHGTYDKLEDDGLIAPGTRVSGEDIIIGKTAPIPLDHEELGQRTQLHAKRDVSTPLRSTESGIVDQVMVTTNQEGLKFVKVRMRSTRIPQIGDKFASRHGQKGTIGMTYRHEDMPFSAQGIVPDIIINPHAIPSRMTVAHLVECQLSKVSALSGFEGDATPFTDVTVEAVSKLLRSHGFQSRGFEVMYHGHTGRKLVAQVFLGPTYYQRLKHLVDDKIHARARGPVQILTRQPVEGRSRDGGLRFGEMERDCQISHGCSSVLRERLFDCSDAYRVIVCDICGLIAIASYKKDSYECRSCQNRTRFSQVYLPYAAKLLFQELMSMNIAPRLFTKNHK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB2, RNA polymerase II subunit 2, RNA polymerase II subunit B2, DNA-directed RNA polymerase II 138 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LFTR_NITEC
Sequence: MIRTLFSDTPFPPLEQALIEPNGLLAAGGDLSPERLISAYQQGIFPWFNQGEVILWWSPNPRMVLFPQELKISRSLHKTLKKNHYQIRTDSAFTQVMQACAAPREKQTGTWIHPEMVAAYTTLHQRGIAHSVETWVDGELVGGLYGVAIGKAFFGESMFSRVPDASKIALVYLARQLERQGYGLIDCQMKTAHLMSMGAREIPRLQFSKLLGKLTDQPEQNRKWHFDFTWPKQQ
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBMX2_RAT
Sequence: MNPLTKVKLINELNEREVQLGVAEKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTVLAVDNFNGIKIKGRTIRVDHVANYRAPQESEDVDDVTRELQEKGCGAKTPPSSPPEVSEDEDAKVTKKPKKDKKEKKKKKEKEKTERPVQAELPSCSRSKTVKETDEQSAKKHSSKPSERAQKSECRERKKSHSGSPDGRTSCRGRAEEPEWEAKKEKHKHEHKPSSRREGEEKSRDKDRGRSSGTHSSRHHGHSEGRSHRSRSRSRSRSPDRSHRHKKHRYSHERESFHASDRRHY
What is the function of this protein?
Involved in pre-mRNA splicing as component of the activated spliceosome.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
RNA-binding motif protein, X-linked 2.
What is the protein family that this protein belongs to?
Belongs to the IST3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRET1_DROAN
Sequence: MSGRDNRGAGGGGGGGGGGGHQPLSSAMGKLKEKLTRVGDELGYHRVESNLSTSNTATSLDTILPEDPFLFPQVSPQRHPQSTVRTQRLLEDEPPLSFRPLLEDDDINEPPTQQLTTQQQRTPLRASGSLELTPLPPPPTSLEIREHRDRQQRSAQVAAEELQRSKQSLKGSRVSFERRDTGNSNSNKQAESSDEDSFEERRTGFQQQKATSVDHKGILKDLKHILANDNRRQFQAKKHVSLDVKGTRFLQDLLKESSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLQGSSTDSDEEGDDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFHTSRQHFQQQRSISTDSRKSRRLYEMDEMGNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIFIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMVDRNITSFEVTPQAASWVGGIMPLAGLAGGIAGGPFIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLAGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGTYMDWSMLAFLGAALPVPFLVLMFLIPETPRWFVSRGREERARKALSWLRGKEADVEPELKGLMRSQADADRQGTQNTMLELLKRSNFKPLSISLGLMFFQQLSGINAVIFYTVSIFKDAGSTIDGNVCTIIVGVVNFLATFIATLLIDRAGRKILLYVSNIAMIITLFVLGGFFYCKAHGPDVSHLGWLPLSCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWTCTFVVTKTFQDMIDVMGAHGAFWLFGAICFIGLFFVILYVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
What is the function of this protein?
Low-capacity facilitative transporter for trehalose.  Does not transport maltose, sucrose or lactose.  Mediates the bidirectional transfer of trehalose.  Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
What are the official names of this protein?
Facilitated trehalose transporter Tret1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGS_ECOBW
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQARELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: ADDA_STRPG
Sequence: MISFAPFLSPEAIKHLQENERYSDQSQKRTAQQIEAIYTSGQNILVSASAGSGKTFVMVERILDKILRGVSIDRLFISTFTVKAATELRERIENKLYSQIAQTTDFQMKVYLTEQLQSLCQADIGTMDAFAQKVVSRYGYSIGISSQFRIMQDKAEQDVLKQEVFSKLFSEFMNQKEAPVFRALVKNFSGNCKDTSAFRELVYTCYSFSQSTENPKIWLQENFLSAAKTYQRLEDIPDHDIELLLLAMQDTANQLRDVTDMEDYGQLTKAGSRSAKYTKHLTIIEKLSDWVRDFKCLYGKAGLDRLIRDVTDLIPSGNDVTVSKVKYPVFKTLHQKLKQFRHLETILMYQKDCFPLLEQLQDFVLVFSEAYLAVKIQESAFEFSDIAHFAIKILEENTDIRQSYQQHYHEVMVDEYQDNNHMQERLLTLLSNGHNRFMVGDIKQSIYRFRQADPQIFNQKFRDYQKKPEQGKVILLKENFRSQSEVLNVSNAVFSHLMDESVGDVSYDEQHQLIAGSHAQTVPYLDRRAQLLLYNSDKDDGNAPSDSEGISFSEVTIVAKEIIKLHNDKGVPFEDITLLVSSRTRNDIISHTFNQYGIPIVTDGGQQNYLKSVEVMVMLDTLRTINNPRNDYALVALLRSPMFAFDEDDLARIALQKDNELDKDCLYDKIQRAVIGRGAHPELIHDTLLGKLNVFLKTLKSWRRYAKLGSLYDLIWKIFNDRFYFDFVASQAKAEQAQANLYALALRANQFEKSGYKGLYRFIKMIDKVLETQNDLADVEVAAPKQAVNLMTIHKSKGLQFPYVFILNCDKRFSMTDIHKSFILNRQHGIGIKYLADIKGLLGETTLNSVKVSMETLPYQLNKQELRLATLSEQMRLLYVAMTRAEKKVYFIGKASKSKSQDITDPKKLGKLLPLALREQLLTFQDWLLAIADIFSTEDLYFDVRFIEDSDLTQESVGRLQTPQLLNPDDLKDNRQSETIARALDMLEAVSQLNANYEAAIHLPTVRTPSQLKATYEPLLEPIGVDIIEKSSRSLSDFTLPHFSKKAKVEASHIGSALHQLMQVLPLSKPINQQTLLDALRGIDSNEEVKTALDLKKIESFFCDTSLGQFFQTYQKHLYREAPFAILKLDPISQEEYVLRGIIDAYFLFDDHIVLVDYKTDKYKQPIELKKRYQQQLELYAEALTQTYKLPVTKRYLVLMGGGKPEIVEV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: ATPL_STAAW
Sequence: MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIGVVIAFMTFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: POXK_PENO1
Sequence: MTATATPVPTVASHAQDITLPPPPKGDITTPILFAQDFQKPSTGYMFIKNPPPAGVPYTNIRGEPAMVTVEDLRGKENSVNLDRDSLQVLQGLTDVPRSPEVNWNSVESVEKTFYPAVEAAIKSAIPGAHTVHIFRHGIRHTQNWPVPYNPPAMIAHLDQTGPAAINRVLRHMGPVEGPRLLQGRYRIVHFWTPLNGPVYTCPVAVASSATVKDNDIQIFVSHLGGIGGLDMPLGRPVAKPDASEQYREDFGAPRYADGQRWFYLSGITQDEALLIQIFDSNALQKDSTVQGGRAVHSAFRDPRTPQGAPDRWSIEVSCLVFSDE
What is the function of this protein?
Hydroxylase/desaturase; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
Hydroxylase/desaturase poxK, Oxaleimides biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the asaB hydroxylase/desaturase family.
Protein: H7_VACCT
Sequence: MEMDKRMKSLAMTAFFGELNTLDIMALIMSIFKRHPNNTIFSVDKDGQFIIDFEYDNYKASQYLDLTLTPISGDECKTHASSIAEQLACVDIIKEDISEYIKTTPRLKRFIKKYRNRSDTRISRDTEKLKIALAKGIDYEYIKDAC
What is the function of this protein?
Contributes to the formation of crescents and immature virions (IV).
What are the official names of this protein?
Late protein H7.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae H7 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Note=Probably transitorily part of the membrane of crescents during immature virions formation. Not incorporated into virions. Probably synthesized, but not retained in viral factories (By similarity).
Protein: YO331_YEAST
Sequence: MSSFIDSIKSTSLSRALTIALGSNNFKSASTINDCKMGLYSSRLLAIPDNFSLVSSNIPSSDCSRAERTFNLILFAIVDLVICCESMAFFNLLLKLPSMLLVSFLTMLVFSISYSWSAFNWISFAFSSASFLMKACILFNSSFTWFGVKAVIAEDMLYRMVRGLFCASFVKQLQTTFLATAIVLC
What are the official names of this protein?
Putative uncharacterized membrane protein YOR331C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FA2H_HUMAN
Sequence: MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
What is the function of this protein?
Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924).  FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924).  Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity).  Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976).  Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity).  Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity).
What are the official names of this protein?
Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, Fatty acid hydroxylase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family. SCS7 subfamily.
Protein: FADR_ECO24
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLIAD_RAT
Sequence: MLVILLMVVVLALSSAQDPNRDFVVSSQDVRERQPSSQQGTVGGQSQESQLRDQQQQQSLQQSQEQQPQPQLQQTKQPQRPVKGQPLPQQQQQQNQRPRPRYQQPRRAV
What is the function of this protein?
May play a role in the formation of the protective mucosal protein pellicle involved in the reinforcement and protection of oral mucosal epithelial surface.
What are the official names of this protein?
Gliadoralin-A.
What are the subcellular locations of this protein?
Secreted.
Protein: MOS2_ARATH
Sequence: MKLSFSLPSKSKPKVTATTADGNNAVDDGTSKEFVTEFDPSKTLANSIPKYVIPPIENTWRPHKKMKNLDLPLQSGNAGSGLEFEPEVPLPGTEKPDNISYGLNLRQKVKDDSIGGDAVEERKVSMGEQLMLQSLRRDLMSLADDPTLEDFESVPVDGFGAALMAGYGWKPGKGIGKNAKEDVEIKEYKKWTAKEGLGFDPDRSKVVDVKAKVKESVKLDKKGVGINGGDVFFVGKEVRIIAGRDVGLKGKIVEKPGSDFFVIKISGSEEEVKVGVNEVADLGSKEEEKCLKKLKDLQLNDREKDKKTSGRGRGAERGSRSEVRASEKQDRGQTRERKVKPSWLRSHIKVRIVSKDWKGGRLYLKKGKVVDVVGPTTCDITMDETQELVQGVDQELLETALPRRGGPVLVLSGKHKGVYGNLVEKDLDKETGVVRDLDNHKMLDVRLDQVAEYMGDMDDIEY
What is the function of this protein?
Required for innate and induced resistance to pathogens such as compatible and incompatible isolates of P. syringae and P. parasitica.
What are the official names of this protein?
Protein MOS2.
What is the protein family that this protein belongs to?
Belongs to the MOS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UNG_CLOB8
Sequence: MSDILKNDWKNYLQSEFQKDYYINLRKFLINEYNSKTIYPNMYDLFNALHFTPYNKVKVVILGQDPYHGPGQAHGLSFSVNPGVKTPPSLINIYKELHTDLGCYIPNNGYLRKWADQGVLLLNTVLTVRAGEANSHKNKGWEEFTNEVIKVLNKKETPIVFILWGNNAISKTDFITNPKHLIIKSVHPSPLSASRGFFGSKPFSKTNNFLISTNQEPIDWQIENI
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRB_MYCPN
Sequence: MEDNNKTQAYDSSSIKILEGLEAVRKRPGMYIGSTGEEGLHHMIWEIIDNSIDEAMGGFASTVKLTLKDNFVTIVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVAREHQQYFLAFHNGGEVIGDLVNEGKCDKEHGTKVEFVPDFTVMEKSDYKQTVIASRLQQLAFLNKGIQIDFVDERRQNPQSFSWKYDGGLVQYIHHLNNEKEPLFEDIIFGEKTDTVKSVSRDESYTIKVEVAFQYNKTYNQSIFSFCNNINTTEGGTHVEGFRNALVKIINRFAVENKFLKETDEKITRDDICEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNSIVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGGTAKTGRDRYFQAILPLRGKILNVEKSHFEQIFNNVEISALVMAVGCGIKPDFELEKLRYNKIIIMTDADVDGAHIRTLLLTFFFRFMYPLVEQGNIYIAQPPLYKVSYSNKDLYMQTDVQLEEWKQQHPNLKYNLQRYKGLGEMDAIQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEQNARNVKNIDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_ECODH
Sequence: MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRLETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEGKNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.