PharMolix/UniProtQA huggingface dataset:
Protein: ALT6_ALTAL
Sequence: MDNERRLVLLTGATGHVGFAVLVEALEAEYNVRVVLREISKADSILSSEPVKNALSSTAAPELSFVEVPDMTVPGAFDSAMQSVTYVVHCASPINRGKFRDFQTELIDPAVKGTTNILKAAHATPSVLRVVITSSNSAIVNHNILPAPGTCVSPSDRQPDYPLDVAMHDADEAYSAAKTSALNATDTFVSSANDLRFDVVSIMPTFVFGPKELAKSPGDIIDGSNVFGIGLVLIKQSWGSLRIEAVSCHIDDVAQAHVQALNHDEDVQFPFKAGTHRSCLLASSFRPDEVRDIVEREFPKESWQGEEAVFRGKGSYAWYHTDYDVSAAEKLLGRKLKGIVEQIRSSGLQVLRIA
What is the function of this protein?
NAD-dependent epimerase/dehydratase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype (PubMed:18435561, PubMed:19749175, PubMed:19449880).  The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units (PubMed:18435561, PubMed:19449880).  ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin (PubMed:19449880).  The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable).  This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable).  The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable).  The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref. 5).
What are the official names of this protein?
NAD-dependent epimerase/dehydratase ALT6, AAL-toxin biosynthesis cluster protein 6.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: RPIA_SALPC
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKGLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQNVVTDNGNVILDVYGMEILDPIALENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: C76K6_SALFT
Sequence: MQVLILLSLAFLASCVVAYSRRRPGGRGAGNLPPGPPRLPIIGNMLQLGQNPHKSLAHLAKTYGPLMSLKLGNQFVVVVSSPEMAREVLQRHGLVFSTPCAPIAVQILGHGEVSMNMLPATSPIWKKLRKIAREKLFSNQALHDTRAVRWERLRKLADYVGRCSGAMNVGEATFTTMSNLMFSTLFSVEITQYADSDSDSGVNKKFREHVNAITRYIGVPNIADFFPIFAPFDPQGLRRKLTYHFGSLLELVQSLIEQRLRARNAATYRKKDDFLEMLLDLSEGDEYDLSVNEIKHLCVDLIIAGSDTSAATTEWAMVELLLHPDKLAKLKAELKSVVGDKSIIEESDISKLPYLQATVKEVLRYHPAAPLLAPHLAEEETQLNGYIIPKNTKIFINDWTISRDPSIWKNPEMFEPERFLDNDIDFCGQHFELIPFGSGRRICPGLPLASRMLHCMVATLCHNFDWELEKGTESKQLQREDVFGLALQKKIPLRAIPIKV
What is the function of this protein?
Monooxygenase involved in the biosynthesis of carnosate, a potent antioxidant labdane-related diterpene natural product (By similarity).  Catalyzes the oxidation of 11-hydroxyferruginol to produce carnosate (By similarity).  Mediates the conversion of miltiradien into miltiradien-20-al (PubMed:27703160).  Also involved in the production of pisiferic acid and derivative products from ferruginol (By similarity).
What are the official names of this protein?
Carnosic acid synthase, Cytochrome P450 76AK6, SfCYP76AK6, Miltiradien-20-al synthase, Pisiferic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DSF2_YEAST
Sequence: MNQNLKNTSWADRIGSDDQERKANSSEVSQSPPPNNSFESSMDSQFSYAHSNKSSISFESIQTTERLLDKLDLSLEDELILQEALLEEENASRNSQLSQTSGPTLCMPASEFPSLRYRTNPSPTYIQARDRSLIIDNLKEKDSTLRGKYSSGKVERHLPVKSRYSYIVEEDYDSETFSGMKPQMNRNEKDYKYPNLENGNRSTNSPNPFNFEKYRIENTRLHHLYPTLISDNNTSVDNNANSKNNRTTSNNINTSTKTDRISEKQSCPNEFTTTQKSNCLYRNGSSTSTNTSFSEVGQLSKPKTQSSFESESSSFSKLKLTKSDTTPIKPSPKRSNSSTSTITKTNTMTNDISLPPTPPYKAHKKKTSLNSLKKLFKSPRTRAKNKKDLESEGSSPIRSATNSLDFSGENIQLPSTSSTINNSSPHLARYIFPPNPVFHFKTASTPQSSTDKKKNSKARPNRTHLRTFSDFHTTEKDSKIGELSALTEQSNKPYHPKVRRRTLSLDGMLPNNSTQCMDSFSHKKEGSNATSKCGKLKFHPEPYDNDESSHIGQAITMRHQGKLEESAQRLKKACACGNKTAFLLYGLALRHGCGVDKNLKLSLGYLMAATDIKSFAAEVLDLDINPLNFASMDDIPDIAPEPTAPALYECGMAYLKGLGMDHPDERKGLKFLEKAALLGHVDSMCLSGTIWSKTSNVKKRDLARAAAWFRIADKKGANLLGSDWIYKEKYMKQGPK
What are the official names of this protein?
Protein DSF2, Deletion suppressor of MPT5 mutation protein 2.
Protein: RS17_AGGAC
Sequence: MTDKIRSVQGRVVSDKMEKSFVVAIERKVKHPLYGKFIRRTTKLHVHDENNEAKLGDLVEVRECRPISKTKSWTLVRVVEKAVIA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SNX20_BOVIN
Sequence: MASHKHPGSPGWTGPICQDMAGTTPKASAPRPDLPRPGPEDHLEAQGSPSSNSSMTTRELQEYWRAQKCCWKHVKLLFEIASARIEERKVSKFVMYQIVVIQTGSFDSNKAVLERRYSDFETLQKKLLKTFREEIEDVVFPKKHLIGNFTEEMISERKLALKEYLSVLYAIRCVRRSREFIDFLTRPELKEAFGCLRAGQYTKALDILMRVVPLQEKLTAHCPVLLVPALCAMLVCHRDLDRPAEAFAVGERALQCLQAREGHRYYAPLLDAMARLAYLLGKDFVSLQKRLEESQLRKPALRGFTLKELTVQEYLS
What is the function of this protein?
May play a role in cellular vesicle trafficking.  Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
What are the official names of this protein?
Sorting nexin-20.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.
Protein: ST7_MACFA
Sequence: MFGTESSLSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTRI
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APT_AGARV
Sequence: MKTVKDYIRTIPDFPEKGIMFRDVTSVIQDADGLKLAIDEMIKRLDGLDFDVIAGAESRGFVFGMPIAYALHKPFVMVRKAGKLPCETVSKTYDLEYGTATIEMHKDSVKPGQKVVLVDDLIATGGTMQAAAELVEELGGEVVKMLFLIELAGLNGRKLLSKYDVDAVVSYDGK
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_ARTS2
Sequence: MSRAVGIDLGTTNSVVSVLEGGEPTVIANAEGGRTTPSVVAFSKSGEVLVGEIAKRQAVNNIDRTIASVKRHMGTDWNVAIDDKKYTAQEISARILMKLKNDAESYLGEKVTDAVVTVPAYFNDAQRQATKEAGEIAGLNVLRIVNEPTAAALAYGLDKGKEDELILVFDLGGGTFDVSLLEVGKDEDNFSTIQVRSTAGDNHLGGDDWDQRVVNYLLNQLKVKGIDLSKDKIALQRLREAAEQAKKELSSSTSTNVSLQYLSVTPDGPVHLDEQLTRAKFQDLTKDLLDRTKKPFQDVIKEAGIKLSEIDHIVLVGGSTRMPAVYELVKELAGGKEPNKGVNPDEVVAVGAALQAGVLKGERKDVLLIDVTPLSLGIETKGGVMTHLIERNTAIPTKRSETFTTADDNQPSVAIQVFQGEREFTRDNKPLGTFELTGIAPAPRGVPQVEVTFDIDANGIVHVSAKDKGTGKEQSMTITGGTALSKEDIDRMVKDAEEHAAEDKARREATDTRNTAEQLAYSVDKLIADNADKLPEEVKTEVKADVDALKKALEGTDDAAVKTAFEKLQASQSKLGEAIYAQAGSPDGATGPAGAESAAGSEGAKADEDIVDAEIVDEDEKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FOLR2_HUMAN
Sequence: MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
What is the function of this protein?
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.  Has high affinity for folate and folic acid analogs at neutral pH.  Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
What are the official names of this protein?
Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP.
What is the protein family that this protein belongs to?
Belongs to the folate receptor family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Protein: RNFB_SHEAM
Sequence: MSAVMIAVVLLGLLALVFGAILGFAAVKFRVEGDPLVDQVESLLPQTQCGQCGYPGCRPYAEAIAGGDQINKCPPGGTATMEKIAELMGVEPQPLSATTEQQVKKVAYIREDECIGCTKCIQACPVDAIVGAGKLMHTVITQDCTGCDLCVEPCPVDCIDMLPVTQDIKTWNWKLSAIPVMQLEEDKQC
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: Y336_RHIL3
Sequence: MGDSDLTAIRRKALRRGRISEYVAAVFLMLKGYRILALRHRTRLGEIDIIARKGDLAVFVEVKARHGEAAAVDAVSVAAQKRIRAASDLWLARQADQARLSQRYDIVAIMPGRLPRHFLDAF
What are the official names of this protein?
UPF0102 protein RL0336.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: TI214_ADICA
Sequence: MNTKILLSLPWPKLMDPYMLLGFYYGLLTTLPVGPSQILCVRSFLLGGNLSGLISISGSVLAQLITASSIYCSPIYLLLLRPHLLTIVAIPYTLLFCLVIKDFPNYQILRPVTSLRDSRVARLFLISFFFQILNPIMLPNSVLTRLIYLYFFRYSTNTVFMVSTFMGWLTGQAAFNFFSRLLLSRVKGDSPILYLVAKRFIYATFSIVSISYAVAYLGRAPVSFWTKKFMNESHDREMNLWEIAEYSDLLWWFFKPWPTSFFDPSRANRSNRFVKNRRFHMNNTFYKGRTSTYFFEKCLTDGKERLSFLALPSLSIFGKEMYQSMAKSRRSFGIRLSYQNWVSKKLAKTKFFEKELTDQIKLLDTGSSFSKTMSRKTRLMGGKRRRIPRTYDPFVNNFRIRIPVSQTFLLEDDLGLSLWEWDKLATERKNRKAKKTVRINAIKDKIFTKDRRWKHGYGNPLPWEPLPSRSKRMFYFIFENRALYDYDLQNILKKIKSSPTLDVTWKEIMDLDYEDHILFLTYLEVGCCHRFGWISPLKAFLRKSSKSLSNVERRIRRLNKIGNLSMDLARYTILYFENNFDIPGGDGDFRYRKLRNVGITFAKGKPRSERLMKRYAKVSDFRRKFLKGSMRSRRRKTLLWKALQEKIRSSFFLRSAERTILFQSLIERLTTSSREEKFSELEKDTDYEFQKQLLDISLSAKRSLIGESKLTRSAIAARSDIGPIHNGRGYMLVFQSRFRKFIKLPVLIVLKNIGRILLRQNSEWNKDWTGWKKEIHINCTFDGEDFSQDELPPRWLREGIQIKIVYPFQLKPWHTDGNEKQHTLQRKHKEIGSKSRELKSKRKLKQKKHKFTYLTVLGYQTDIPFGTIQKKTSFWKPVRRKLIRICKRSLPRQIKQAYQFIHSRFEKVSKLNSTPSKKLNLISNLRQGGKLLSDYSLDEKSWMKTSSTNYVNEKTKPNCNVISNSERFIAIGGEMSPANVTRKQLVTRDQVEREFLMSIVAVDSKNLLDEKIDDPYSKITSKDLETGDTTSGDINLVNSTKFERKQLVDSEEAGLSLYLLVRELIETFVSVLINLPFTINRIFVHYFTEFLALYTKLAGILDNINEGSNLSTRSKSLQFDLPSQTCIYIDMWNIGMRGSLNLDLLVNDKRSSSNCGVKNRQSGIYVETDGVSNLYQPKMYEKQTPVHYNLIATKFLSPEIRNNHVNDLTMCFDTETGKTDEEFFDEKVARSIENWGFLNKSCKLDEINWNEWLYSLSRYNLPLTAWRNIAPRKWKVCLSELSSIETNTITELKDQVSQNKLHSYYSIYTKKSFLRNKISNFSKLRKHRNLLQNLTDSVQNGDVENLSVQRDIMEQRFHCKSCIQKSSRGGRNRISKFVHFLSSNVESKNNLNLQIDLLSWLDPDIAKTKIFLKKKKKAKQLKNPLLRNHYRYRYVLDISGRFQKVLNQLNDLTLDEREDADYIFRWKFKFETELEKFRNLISLTRMLGDDQDLITLCTNIEVNSDLLNLQFNAKTKRDMFHNLSVVSAHRLRLVFDDQDLLYKIINPLLKFKGRLRGIFRRRLYRNVYNGSYISNLSHILTERNCKQSCLYNIDDLLSPRRRREFRFLYCLLSPKIEYSQYISRIKKIDNAEKKQTLYHLPRPIRIQKIKRFLWPSHRLEEAACTGRSCVGVMTGSRFVTLRIRMYPIPLN
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: GLNB_RHILO
Sequence: MKKIEAIIKPFKLDEVKEALQEAGLQGITVTEAKGFGRQKGHTELYRGAEYVVDFLPKVKIEVVLGDDAVEGAIEAIRKAAQTGRIGDGKIFVSNIEEVVRIRTGETGMDAV
What is the function of this protein?
In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP.  P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.  Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS.  P-II indirectly controls the transcription of the GS gene (glnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA.  When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: GERPD_BACCE
Sequence: MNLNVVNRELKVGQIKMNGVSSSALFLIGDANLLILSSILDTPFETVTEGPFVPLVTDVPPTPG
What is the function of this protein?
Required for the formation of functionally normal spores.  Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor.
What are the official names of this protein?
Probable spore germination protein GerPD.
Protein: YF036_YEAST
Sequence: MTIVHFVGSLFFFFFFSYIFFYNDHGLYTWGCNFAMESPSPTSSPSLPTRFTPCPVAVLPSSSSPSWSFSTSCMPESTCSEISTSFFDTFNSSSDLFRSRICLLSDNRSFSIFSDSFTYFSFSISSCVSRSHSFVNLLSNFSMVSLTNSWIIAWLSSMYFSEISLDLSETLPNLSSPCSSVWTASFTHSINFEPDTLPSRLSPPLPFSVEPTTSRM
What are the official names of this protein?
Putative uncharacterized protein YFR036W-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RECF_STAAT
Sequence: MKLNTLQLENYRNYDEVTLKCHPDVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFNADYAKIEGELSYRHGTMPLTMFITKKGKQVKVNHLEQSRLTQYIGHLNVVLFAPEDLNIVKGSPQIRRRFIDMELGQISAVYLNDLAQYQRILKQKNNYLKQLQLGQKKDLTMLEVLNQQFAEYAMKVTDKRAHFIQELESLAKPIHAGITNDKEALSLNYLPSLKFDYAQNEAARLEEIMSILSDNMQREKERGISLFGPHRDDISFDVNGMDAQTYGSQGQQRTTALSIKLAEIELMNIEVGEYPILLLDDVLSELDDSRQTHLLSTIQHKVQTFVTTTSVDGIDHEIMNNAKLYRINQGEIIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHRF1_CAEEL
Sequence: MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYATPPVDSNDLMDEVFGRVNLPGVTMSSHTEVLPPTDDISSVSSLSSHRESAVDVPVSHQYVPSYATESHQKHEQHSQTHHHHHQHQQPSPLSNGSSHGYAASSTSGYDDDDIYHLSAREARERLRMKNRKHHLHEMSLNEKYQLVSNM
What is the function of this protein?
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity).  Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis (PubMed:22916205).  May play a role in promoting fertility (PubMed:30560135).
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1, NHERF-1, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1.
What are the subcellular locations of this protein?
Cell projection, microvillus membrane. Apical cell membrane. Note=Co-localizes with aat-6 at the apical cell membrane of intestinal cells.
Protein: FABZ_LISIN
Sequence: MLDIKKIKEILPHRYPFLLVDRVISVEEGKKVTAIKNVTANEEFFNGHFPEYPVMPGVLIVEALAQTSGIAMMQSEANKGKIGLFAGIDGCRFKRQVVPGDQLLLEAEITRMRGAIAKAKVKATVEGDLVCEAEIMFALSDLPQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_ANADE
Sequence: MKKADAAARARDLRERIRAADHAYYVLDQPVLADAEYDRLMHELQAIEAEHPELVTADSPTQRVSGAPSERFERVVHREPMLSLGNVQSDDELHEFDARVRRLLGLPEGEAVGYVVEPKLDGLAVELVYRDGAFTGGSTRGDGVNGEDVTANLRVVGGLGANRGVPHALEGTPPPRVEVRGEVLLFKEHFEAMNRQLVRAGDEPFANPRNAAAGTLRQLDWRVTARRPLSFVAYEALVPGGDPWRTHWEKLEALAAWGFETNPENRRCRGLGEVLAYRDRMAERRFELPYDTDGIVVKVDDLDWRRRLGAASKFPRWAVAFKYPPQEEATRIRRIWASVGRTGVLTPVVDFDPVRLSGAMVARATLHNEDEMRRKDILEGDWVLVRRAGEVIPEVVKPLPERRTGEERPFRFPAECPVCGARVVREEGEKVYRCTGAACPAQLVGRICHFAQRRALDIEGLGEKLAAGLVERGQVKDFADLYAVPFEVWQQLFSRPRKEQDAGAARELPEKSAQNMVAALERSRSTTLRRFLFALGIPQVGEATAATLARHFGDLARILDADEEALKGVRDVGPETASEIRAWTQEPQNRRVVERLLAAGVRPEPEVVEARGPFAGKTVVLTGGLSAMSRDDAKAEVERRGGKVSGSVSRKTDLVVAGEEAGSKLEKARSLGVRVVGEEEFVRLLKE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RS2_BDEBA
Sequence: MAQVTMKEMLDAGVHFGHQTQRWNPKMKPYVYTARGGIHIIDLQKTVVRANKAAEFVKEIAANGGRLIFVGTKKQAIEPIQEAAAKCGQYYVTKRWLGGMMTNFETIKSSIDRLRKIDTMKEKGEFNYLTKKERAKLEKEYLRLTDFLAGIRDMKEMPSAMFVVDLPKEHIAVAEAKRLGIPVVAIADTNSDPESVDFAIPGNDDAIRSIKLFSNLVADAYLEGAKEWEGKLRTMTDKQSDVAKEAKADGKEEAPKRRGAGAKAGAKEAPKKSAGPAVVKATKSRKLVAAGTAEEVEIQAELEQGQSTDESAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YKT8_SCHPO
Sequence: MSSSIPPRLYDMSPTESKKQEDVSETELVYPVELADATIQPSKSDDDLFDSNDFSKTYLAKSRILSNAMNEIGFGRYQWYLFFVAGFGWMSDNIWPVCTSLILMRLDEVDGPHPPAEGRAPYLTLSQNLGLLVGAMVWSLSADTIGRRWAFNLTFLFTGVFAVIAGASPNFASICVFDALWSFGVGGNLPVDSAIFLEALPSSHQWLLTVMSFWWAIGQVIANLVSWGLISNFSCPDDESVCHRADNKGWRYFLFTMGGMTLLMFAARFLVSVYESPKFYLAKGDDYKAVETIHKIARINGKTCTLTVEELYAIDRQEQEESDLDDSKSSDAKSVTQGTTNLIVEKLRKYNFEHIRQCFGSRKLAISSILVILSWAVIGLAFPLYNAFLPYYLETRGNANEPLSVAKTYRNSLIVSAIGVPGSLIAGVLVEFRIGRKGTLCLSLILTGVFLFASTTAKTSNAYLGWNCTFSFFSDIMYGVLYAYTPEVFPSKVRGTAVGLAASANRILGIFSPVIAMRANLTTSAPIFVSGALFIFAGILVVFFPYEPRGKSSF
What are the official names of this protein?
Uncharacterized MFS-type transporter PB1E7.08c.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Protein: DESM_XENLA
Sequence: MSQSYSSNQRASSYRRTFGGGSPSFSTRSSFGSKGASSSSVSSRVYQVSRSTAAPSLSSFRATRVAPVRSSYGADVLDFSLADAMNQEFLQTRTNEKVELQDLNDRFANYIEKVRYLEQQNQILVAEVNRLKGKEPTRVNELYEEEMRELRRQVDLVTNQRARVEVERDNLVDDLQKLKQRLQEEIQLKEDAENNLAAFRGDVDAATLARIDLERRIESLQEEIAFLKKIHEEEIRELQAQFQEQQLQVEIDVSKPDLTAALRDIRAQYENIAAKNVAEAEEWYKSKVSDLNQAAKKNNDAMRQSKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRDLEEKFSGEAAGYQDTIGRLEEEIRNMKDEMARHLREYQDLLNVKMALDMEIATYRKLLEGEESRITLPIQTFSALSFRETSPEQRASEVHTKKTVMIKTIETRDGEVLSEASQQHQEIL
What is the function of this protein?
Muscle-specific type III intermediate filament essential for proper muscular structure and function.  Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity.  In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
What are the official names of this protein?
Desmin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma.
Protein: SCX1_ODODO
Sequence: GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels.  The toxin affect mammalian sodium channels Nav1. 7/SCN9A (EC(50)=4. 5 nM), Nav1. 4/SCN4A (EC(50)=9. 6 nM), Nav1. 6/SCN8A (EC(50)=30 nM), Nav1. 5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM) (PubMed:16038905, PubMed:16641312, PubMed:23527544).  In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw (PubMed:26999206).
What are the official names of this protein?
Alpha-toxin OD1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TBC29_HUMAN
Sequence: MGHLDKEGLCTQGSSFSWLLRVLNDGISLGLTPCLWDMYLLEGEQMLMLITSIAFKVQRSLYEETNKETWGPATPRALKGTGRARPICESLHSSLQALTASESSRGPSLLQTPPRVPGQQALSRGDKGISVSLSLPSLPSRRGRCGRIIG
What are the official names of this protein?
Putative TBC1 domain family member 29.
Protein: LPXD_VEREI
Sequence: MSLLLGQIVDALGGSLQGGSRDTPICRIAPLQAAGPGDLSVLSHPRYQQQLAASRAACVIVAPALRAAALARGACILAEQPYAYFARATQLWRQHHAPAPAPGVHASAVLDPTAQVHPTASIGPLCILERGAQVGAGSRLQARVTVGADCRIGARCLLHAGVVVGADGFGFAPEDGQWIKIEQLGAVRIGDDVEIGANTCIDRGTLQDTVIEDGVKLDNLIQIGHNVRIGKHSALAGCVGVAGSARIGAHCTIGGGAIVLGHLELADHVHISAATVVTRSLTRPGQYTGLFPIDDNARWEKNAATLKQLHSLRERIKALEQALKAA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.