PharMolix/UniProtQA huggingface dataset:
Protein: THIM_CROS8
Sequence: MSSDLLCGSHAAPVVTQLRRHAPLVHCITNDVVQNFTANVLLALGASPAMVVDTDEAAQFAAIADALLINLGTLTRPQQQAMRAAIDSACAAGKPWTLDPVAVGALTLRTEFAQEILARRPAAIRANASEIRALTGESGGGRGVDATESAHQAREAARLLARRTGAVVAVTGEVDYITDGERTVAVEGGTAMLTRVVGTGCALSAVVAACCALPGDRLENVATACWLMKRAGEEALTVSRGPGSFASALLDNLHAQAFGGAYETH
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: DNLI_BPT6
Sequence: MILKILNEIASIGSTKQKQAILEKNKDNELLKRVYRLTYSRGLQYYIKKWPKPGIATQSFGMLTLTDMLDFIEFTLATRKLTGNAAIEELTGYITDGKKDDVEVLRRVMMRDLECGASVSIANKVWPGLIPEQPQMLASSYDEKGINKNIKFPAFAQLKADGARCFAEVRGDELDDVRLLSRAGNEYLGLDLLKEELIKMTAEARQIHPEGVLIDGELVYHEQVKKEPEGLDFLFDAHPENSKVKDFTEVAESRTASNGIANKSLKGTISEKEAQCMKFQVWDYVPLVEVYGLPAFRLKYDVRFSKLEQMTSGYDKVILIENQVVNNLDEAKVIYKKYIDQGLEGIILKNIDGLWENARSKNLYKFKEVIDVDLKIVGIYPHRKDPTKAGGFILESECGKIKVNAGSGLKDKAGVKSHELDRTRIMENQNYYIGKILECECNGWLKSDGRTDYVKLFLPIAIRLREDKTKANTFEDVFGDFHEVTGL
What is the function of this protein?
DNA ligase, which is expressed in the early stage of lytic development, has been implicated in T4 DNA synthesis and genetic recombination.  It may also play a role in T4 DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: PROC_CANLF
Sequence: MWQLASLSLLLTICGTCSTAAPPGSVFSSSESAHQVLRIRKRANSFLEEIRAGSLERECMEEICDFEEAKEIFQNVDDTLAYWSKYVDGDQCAALPPEHACDSPCCGHGSCIDGIGAFHCDCGRGWEGRFCQHEVSYINCSLDNGGCSHYCLEEEGGRHCSCAPGYRLGDDHLQCQPAVKFPCGRPGKQMEKKRKHLKRDTNQTDQIDPRLVNGKVTRRGESPWQVVLLDSKKKLACGAVLIHTSWVLTAAHCMEDSKKLIVRLGEYDLRRWEKGEMDVDIKEVLIHPNYSKSTTDNDIALLHLAQPAIFSQTIVPICLPDSGLAERELTQVGQETVVTGWGYRSETKRNRTFVLNFINIPVAPHNECIQAMYNMISENMLCAGILGDSRDACEGDSGGPMVTSFRGTWFLVGLVSWGEGCGRLHNYGIYTKVSRYLDWIHSHIRGEEASLENQVP
What is the function of this protein?
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.  Exerts a protective effect on the endothelial cell barrier function.
What are the official names of this protein?
Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Endoplasmic reticulum.
Protein: ATPL_RICCK
Sequence: MDIVSLKFIGVGLMAIGMYGAALGVSNIFSSLLNAIARNPAAAENLQRMALIGAGLAEAIGLFSFVIAMLLIFS
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGC_ACIBT
Sequence: MISVGIVGGTGYTGVELLRILLRHPKAQVRVLTSRTEAGKPVADMFPNLRGHTDLQFSDLNIDALKECDVVFFATPHGVAMQHAKDLIAAGTKVIDLAADFRLQNLEQFEKWYGMEHACPDVLKDSVYGLTELNREKIKQAQVIGNPGCYPTTVQLGLAPLLKSAQALIETKNIIIDAKSGVSGAGRKASLGMIYSENADNFKAYGVAGHRHHPEIVEALENIAGKKDVFEGLLFVPHLVPMIRGMLSTIYVDLTEAGKQTDLQALYENFYANEKFVDVMPANSSPETRSVRGANELRIALYKPQPNKLIILAAQDNLVKGASGQAVQNMNLMFGFNEDEGLQGIGLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_RHILW
Sequence: MKLNEIKDNEGSTHSRKRLGRGIGSGSGKTGGRGVKGQKSRSGVAINGFEGGQMPIYRRLPKRGFNNIFASDFVVVSLARIQAAIDAGKLDAKATVDAAALKAAGVIRRTKDGVRVLADGELKAKITIVVAGASKPAVEKIEKAGGTVTLLSAPAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RADIL_DANRE
Sequence: MFYGSSSASMSLPSKNRLKRQSRTFTQVLYRTLSYRDRRSVTDLPEQVRDDPAELSTQSSAPGVLKIFGDEISAGANYKSVLATPRSSAQELIKEALERYSLNKTSACNFVLCDVIGRFEGPDRRWRTECLRALGNNEKPLLLQDLWKPKEGFSRRFELRRRAEVEELAAKEKDTVTADINAQARKLQRNRAKGTMTLQHGSSFCRSLSETSLNLVGLPGEEPKRYYSTLPGPIRTRSARDSEIRKERDGGGVKHSLYQSPHLLLLQGYNQQDCLVYLLNREQHTVGQETASARPNICLSSPDVLPLHCRIRRAAQRRSSSDQRLLLEPVAHGNVLVNFMRIERPTPIRHGDLLSFGAHYIFLYKDPLSAKPLPAQTLTRLRTLAKLCDGESGGLPEKGDACRMCGAVLHEPAASSRRSSKAPARGSQKRKLALEFERAHEDALVNRVLTLIEPSGDDHKLTPAYLLCLCIKHSANTFPPGSFGKLLQKIAKRIQTIAWEKTKELAQKQAQHQDPASLSLLSISDLVPDLQFIFFWMSNAIEILYFIQQKSPAYMQTIELMDDKAGSKESLLSATISANEEAMTILEEVIMYTFQQCVYYITKTLYVVLPGLLDCNPFGTEPSSEQCRRAAGVCVCAVCVMPEAVRRVVSVFQTTSDLLQQYQVHSEIQSQMFAYLFFFTNVSLFNQLIDKGPARGWFQRSRVLQIQASVKILLDWAKGAGHNHLAQKFFAKFCSTVTILASPPQQLSQMSWKALCAEHPSLKPVQLHRILTQYQLMAELGPLPIWQPSSEDEAYIYRTVDLLESFENHPPIVLPSAGFKVDLESDCVEDSIYRQLLYVRHFVWGLRTKTHPSNGCTDRQDAQREPPQPHSSPHPAPSVRGEGEGEVRSSSTTLGGRGEGAGAEDRTRDKPTHGIHYRNGSGARYANQSQATDSSCILTPPNTPLYPEHTYIQSNTAHYPEHASQEHTHTHSHTKTNGCMRSTPEHKKINGFISNGIEGPLSGCGFPFPVPVSHLGPKSDDICSVFVVDLDKGPYGLGMGLIDGLHTPLNSPGIYIRTLIPDGPAAADGRLCIGDRILAVNGTSLIGADYQSAVDLIRLGGGRLRFLVAKSDLEVSEKISASSC
What is the function of this protein?
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
What are the official names of this protein?
Ras-associating and dilute domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the RADIL family.
Protein: B2MG_PANTR
Sequence: MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
Protein: THIC_SULDN
Sequence: MRSLWVEKRKDDPVKTQMYYAKQGIITQEMEYVAKIEKLSPELIRSEIARGRLIIPANVNHTTLEPMAIGIAATCKINANIGSSAIASDVQGEVEKMQVSQHYKADTAMDLSTGGDLDEIRKAVIASSKIPIGTVPIYQILHDVGNKIEDLSIEVMLEVLERQAKQGVSYFTIHAGFLLETMPKIAKRKMGIVSRGGSLMAAWMMHYHRENPFYTAYDEILDICARYDVALSLGDSLRPGCLADASDDAQLGELKVLGELTLRAWEKNVQVMIEGPGHVPLNQIERNMKLQRELCHEAPFYILGPLVTDIAAGYDHISSAIGAAVGGWHGASMLCYVTPKEHLGLPNANDVREGIIAYKIAAHAADIARGRKGARDIDDEMSDARYRFDWNRQFELALDSERAREYHDETLPQDVFKEAEFCSMCGPKFCSYKITQSIMDNPEAIEQIAREVKEREALGA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PHNPP_EGGLE
Sequence: MIEDLHVHSTMSDGSDTFEQVLEQAAQRGVERLAFTNHDTTAGLTAARELGERLGVQVVGGIEVSAYDFERGRKVHILGLGVEEGAPALAALCGSTLERRHANSLWQLDRLVEAGYEVDVERALELGRASTCLYKQHLMAALTSEPYPSAAYRTLYRSLFKNGGICDRDIDYVDARDAVRVVVEDGGLAVLAHPGQLDSYDLLPDLVECGLGGIERFHPDHTLADHARCAELAVRYRLVCTGGSDYHGKFGRVPHVGFRVPA
What is the function of this protein?
Involved in degradation of methylphosphonate.  Catalyzes the hydrolysis of the phosphate ester at carbon-1 of 5-phospho-D-ribose 1,2-cyclic phosphate to form ribose 2,5-bisphosphate.  This intermediate is then hydrolyzed to ribose-5-phosphate and inorganic phosphate.
What are the official names of this protein?
Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase, Cyclic phosphate dihydrolase, cPDH.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: PUR7_STRP7
Sequence: MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y1931_YERPY
Sequence: MINKTLLGLSLGALMFTAGSAVAADYKIDKEGQHAFIEFRIKHLGYSWLYGSFNDFDGSFTFDDKNPAADKVNVVINTNSVDTNHAERDKHLRGKSFLNVAKFPQATFESTEVKKNGDGYSVIGNLTLNGVTKPVTLESKLTGQGNDPWGGYRAGFEANGNIKLKDFNITTDLGPASQEVELILSVEGVQVK
What are the official names of this protein?
UPF0312 protein YPK_1931.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: DPF3_CHICK
Sequence: MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDSRLKLLEIKPETSHLPGKTELITETEFITKMSVDLRRFLSCKLYTSEVDLPLKKDGFTSESTTLEALLRGEGIEKKMDTKEEDPIQEIQRVLENDENADEVNEEEDLEEDIPKRKNRPRGRPKTPTWKKIFQKNARGSGGGRRRNDAASQDDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAREQETRSSPVHRNENHKPQKGPDGVIIPNNYCDFCLGGSNMNKKSGRPEELVSCSDCGRSGHPTCLQFTTNMTEAVKTYQWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLNPPVFEPPEGSWSCHLCRELLRERASAFGFQA
What is the function of this protein?
Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Specifically binds acetylated lysines on histone 3 and 4.  In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling.  It thereby probably plays an essential role in heart and skeletal muscle development.  Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development.
What are the official names of this protein?
Zinc finger protein DPF3, Zinc finger protein cer-d4.
What is the protein family that this protein belongs to?
Belongs to the requiem/DPF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4BC_SINFN
Sequence: MPNETKRERLRELGALNARPEAVRAPWFRESTFFDPLDLVQVKYEMLRHVQEDGVNKADAAALFGLSRPTYYQAEAAFERDGIAGLLPRTRGPKSAHKLTDEVMQLIEQNQHAGAPLQARSLAELLHSTLGISVHPRSIERAIARKKKR
What are the official names of this protein?
Uncharacterized protein y4bC/y4pJ.
What is the protein family that this protein belongs to?
To Rhizobium NGR234A y4oM.
Protein: GLMM_HELPJ
Sequence: MKIFGTDGVRGKAGVKLTPMFVMRLGIAAGLYFKKHSQTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEERAIEEIFHDEELLHSSYKVGESVGSAKRIDDVIGRYIAHLKHSFPKHLNLQKLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINEQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAVVATSMSNLALKEYLKSQDLELKHCAIGDKFVSECMRLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKLVSSIALNPFELYPQSLVNLNIQKKPPLESLKGYSALLKELDQLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGQLC
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ARRD3_BOVIN
Sequence: MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFNTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLYCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLGLSLPERPEAPPSYAEVVTEEQRRNNLAPGSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQPADDRPSCPSR
What is the function of this protein?
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors.  Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation.  May recruit NEDD4 to ADRB2.  Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.
What are the official names of this protein?
Arrestin domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Endosome. Early endosome. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis.
Protein: ATG15_CRYNJ
Sequence: MYIPGPLRLSSYLLPFLSSPSPPAQSSPDTRTISFKPVHAHGHAFVDNASTPTLLFLDQSPSASLYAHDYPIGAFGDDYVLPRLTSDVLEIRTRKKLIRRPKVRPPRIISWAQSYRAQALHFNGINNNNDNSNKSISLPESWLAPDLANPSDEWSDVEVTVPDLTDRQTVITLAKMSSNAYVTPGGAGWYTLNDWNASMPFGWEPDADGLRGHVFADEKNETVIISIKGTSAGVLGSGGPTAKNDKFNDNLLFSCCCARVDFSWTPVCDCYAGGYKCGQTCLEDALVSESVYATVGTNLYNNITYMYPNATIWLTGHSLGGAVSSLIGLSFGAPAVTYESPGELLPASRLHLPLPPGMPANLSGITHVYHTADPIAMGVCNGPYSSCYAAGFAMESKCHTGETILYDTVRVKGWSVDVRTHRIEEVIDKVLADPWPEEGEGKSGVWEKAVEGWYRAADRVRAALDESVVRDDVNVWWGWGRRGPKRQPGGEDPGWRKHGGVPKPVSEEDCVDCYKWEFGEWN
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: CENPJ_HUMAN
Sequence: MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKEEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTEL
What is the function of this protein?
Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387).  Inhibits microtubule nucleation from the centrosome.  Involved in the regulation of slow processive growth of centriolar microtubules.  Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797).  Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124).  Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).  May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).
What are the official names of this protein?
Centromere protein J, CENP-J, Centrosomal P4.1-associated protein, LAG-3-associated protein, LYST-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the TCP10 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized within the center of microtubule asters (PubMed:11003675). During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (PubMed:17681131).
Protein: BAUB_PSEAE
Sequence: MSGRPQAVPTVQVDNAEVIVTEWRFAPGAETGRHRHGHDYVVVPLTDGTLLLETPEGDRHAPLVAGQAYFRKAGVEHNVINASAHEVVFVETEIK
What is the function of this protein?
Involved in the degradation of beta-alanine.
What are the official names of this protein?
Beta-alanine degradation protein BauB.
Protein: ACAP1_MOUSE
Sequence: MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSCLLESGQHYLAAGRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALRTARAGYRSRALDYALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSDDMGSLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL
What is the function of this protein?
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.  Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity).
What are the official names of this protein?
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, Centaurin-beta-1, Cnt-b1.
What are the subcellular locations of this protein?
Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPB_BIFLD
Sequence: MADNQTTAAEPTNGRVTRVQGSVIDVEFPVGHLPDIYNALKVTIVNTSAKEEGEAKETEITLEVEQHLGDSTVRCVALKPTDGLVRGASVSDTGAPISVPVGDVTKGHVFDVSGNILNKKPDETITVSERWPIHRNPPAFDQLESKTQMFETGIKVIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIQRVAQNHGGVSVFAGVGERTREGNDLIGEMAEAGVLEKTALVFGQMDEQPGTRLRVPLTALTMAEYFRDVQNQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGSLQERITSTRGHSITSLQAIYVPADDYTDPAPATTFAHLDATTELSRDIASKGIYPAVDPLSSTSRILDPRYVGQAHYDCANRVKAILQRNKELQDIIALIGIDELGEEDKTTVNRARKIEQFLGQNFYVAEKFTGRPGSYVPADETIEAFTRICDGVYDDVPEQAFSGIGGIDDLEEKWHNMQKELGA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRIM5_GORGO
Sequence: MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHEKSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAQECQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKRLTKSETEMVQQTQSVRELISDLEHRLQGSVMELLQGVDGVIKRMENVTLKKPETFPKNRRRVFRAPDLKGMLEVFRELTDVRRYWVDVTVAPNNISCAVISEDMRQVSSPKPQIIYGAQGTRYQTFMNFNYCTGILGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDATCNIEKNENYQPKYGYWVIGLEEGVKCSAFQDGSFHTPSAPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPYLNPRKCRVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: IPYR_MOUSE
Sequence: MSGFSSEERAAPFTLEYRVFLKNEKGQYISPFHDVPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDKHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYKDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKDFAVDIIKSTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACSLPTDVDKWFHQQKN
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_BACFN
Sequence: MEITNAEFVISNTDVKKCPAGTFPEYAFIGRSNVGKSSLINMLTGRKGLAMTSATPGKTMLINHFLINNSWYLVDLPGYGYARRGQKGQKQIRTIIEDYILEREQMTNLFVLIDSRLEPQKIDLEFMEWLGENGIPFAIIFTKADKLKGGRLKINISAYLRELRKQWEELPPYFITSSEERLGRTEVLNYIESINKELNSK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.