PharMolix/UniProtQA huggingface dataset:
Protein: RL20_ANOFW
Sequence: MPRVKGGTVTRRRRKKILKLAKGYFGSKHRLYKVANQQVMKSLMYAYRDRRQRKRDFRKLWITRINAAARMNGLSYSRLMHGLKLAGIEVNRKMLADLAVNDAAAFTQLANIAKENLNK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: Y335_METJA
Sequence: MQSIFLPVLNPTTIDGQEITEEWIKKYGPTLRGKPVNIDHNYYSNGNLAVGDVVDVYFNPEGNLYAHIRIFDEIYWRLVDNGIKIKGVSFEFNDDGVGEEGIMKGLALCLESDPKVDFARLVEGNYVLEVLASIKRDSMDTKTQEKTEPKKIKDMTEEEFEKFLHEKIEQILASHKKENEDKDKSDNEDDKVVEILASKMDELVAVNKSVLKQLEEIRKAQKEILASAPVPPSGSGNSGHRRANLGL
What are the official names of this protein?
Uncharacterized protein MJ0335.
Protein: PUR7_ECO24
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DNAJ_SHIB3
Sequence: MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGQHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSM2_RAT
Sequence: MHWLWKIPRLCTFWGTEMFHRTFHMNIKKLMPIQWGHQEVPAKFNFASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISKQTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARAIVAGDEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQCVETVSQESAAIYFTSGTSGPPKMAEHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLEIREIYGQTETGITCRVSRTMKVKPGYLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWLLGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG
What is the function of this protein?
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity).  Capable of activating medium-chain fatty acids (e. g.  butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e. g.  benzoate (By similarity).
What are the official names of this protein?
Acyl-coenzyme A synthetase ACSM2, mitochondrial, Acyl-CoA synthetase medium-chain family member 2, Benzoate--CoA ligase, Butyrate--CoA ligase 2, Butyryl-coenzyme A synthetase 2, Kidney-specific protein KS, Middle-chain acyl-CoA synthetase 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PRX3_PENRO
Sequence: MLSLKAFLALSLSIHLSQGLVASVSHRRANACTELSRSYPDSTIHPGSSVFAEDVIEPWSQTCQTTPTCVFAPASAEEVAGGLAILRKADQTFAVRTQGHMPIPGAADISNGVLMVTTSLNSVQYADDSKSVVQIGAGNRWLDVYKVLAKDNLAVVGGRFGQVGVSGLLLGGGISYFNSDHGWGANSVVNYEVVLANGTVCAANAQQNSDLYWALKGGSFNFGIVTRFDLATFSVPYMWGGSAFYDASALDPLVNAYASYAVASGGSSDPAAHSDPSILYNVTTGEVSGYGIYMHRGDDPAPAALKNFTDIPSTFQDFRVGKTILGLENDTTPVNFGVGNRRQLFSSTALASSAEAVYLVNQTFFDVIAANPQIKTTTDLSVTNTYQLFTPGMIRAAKASGGDPIGLYDPLGNGVLAVLYGGNWADAKDDEIIYKFFQDMIDELDNRAKKLGLYYDFVYLNDAAPTQTKDIFQKFSNGTALPKLREIAESYDPDQVFQTLTPGGFKLINSPA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF6 is probably also involved in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
FAD-dependent monooxygenase prx3, PR-toxin biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: Y158_UREU1
Sequence: MLNKNKRWYLIALYDIYQGLLTTKQCEYFNLHYFKDLSFSEIAELKEVSKSAISDCLNKVCDQLLKYEQALLIYEKNKKRNDLYTLINDSELVKKLKDI
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein UUR10_0158.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: BCAP_MOUSE
Sequence: MAASGWGRGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKTQTYRLVPDASFSAQDLWVFRDARCVLVLLSAGLVGCFGQPGLLPMLQRACHPPQRVVRLLCGVQPGDEDFQAFFPDWAHWQEMTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDERELPFSKQTNLPPEISPGNLMVVQPDRIRCGAETTVYIIVRCKLDEKVSTEAEFSPEDSPSIRVEGTLENEYTVSVKAPDLSSGNVSLKVYSGDLVVCETTVSYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEDDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKTHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDDELYESMAAFAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEGNSVKPASWEREQHHPYGEELYHIVDEDETFSVDLANRPPVPVPRPEASAPGPPPPPDNEPYISKVFAEKSQERLGNFYVSSESIRKEPLVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRESITRRRKEKPKSGKHTDLEITVPIRHSQHLPEKVEFGVYESGPRKSVLPARTELRRGDWKTDSMSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEIPEITRSRGPGPTQVDGAPVVTGTPVGTLERPPRVPPRAASQRPLTRESFHPPPPVPPRGR
What is the function of this protein?
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway.  Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1.  Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production.  Also involved in the activation of PI3K in natural killer cells.  May be involved in the survival of mature B-cells via activation of REL.
What are the official names of this protein?
Phosphoinositide 3-kinase adapter protein 1, B-cell adapter for phosphoinositide 3-kinase, B-cell phosphoinositide 3-kinase adapter protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: PRMA_ENT38
Sequence: MPWIQLKLNTTGANAEELSDALMEVGSVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMKDVVAILENHPLLGAGFVHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWRDVPDPNAVNVMLDPGLAFGTGTHPTTSLCLQWLDGLDLEGKTVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAQRNGVSDRLELYLPNDQPDIMKADVVVANILAGPLRELAPLISVLPVEGGLLGLSGILASQADSVCEAYTELFTLDPVVEKEEWCRITGRKK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP176_ARATH
Sequence: MAYAHVFASLTISTISLRRFLPRLHRNHSVKPNSRIICNLKLNYSAGKFREMGLSRSVELDQFITSEEEEGEAEEIGEGFFEAIEELERMTREPSDILEEMNHRLSSRELQLMLVYFAQEGRDSWCTLEVFEWLKKENRVDEEIMELMVSIMCGWVKKLIEDECNAHQVFDLLIEMDCVGLKPGFSMMDKVIALYCEMGKKESAVLFVKEVLRRRDGFGYSVVGGGGSEGRKGGPVGYLAWKFMVDGDYRKAVDMVMELRLSGLKPEAYSYLIAMTAIVKELNSLGKTLRELKRFARAGFVAEIDDHDRVLIEKYQSETLSRGLQLATWAVEEGQENDSIIGVVHERLLAMYICAGRGPEAEKQLWKMKLAGREPEADLHDIVMAICASQKEVNAVSRLLTRVEFMGSQRKKKTLSWLLRGYVKGGHFEEAAETLVSMIDSGLHPEYIDRVAVMQGMTRKIQRPRDVEAYMSLCKRLFDAGLVGPCLVYMYIDKYKLWIVKMM
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g30100, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RESD_BACSU
Sequence: MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIAKGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDDYIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTEVSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVSPEAAKKIVTVWGVGYKFEVGAE
What is the function of this protein?
Member of the two-component regulatory system ResD/ResE.  Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration.
What are the official names of this protein?
Transcriptional regulatory protein ResD.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_CAMJR
Sequence: MENLIIYAFIYLLSSIPFGLILAKFFAKTDIKKEGSKSIGATNVLRVVKEKNPKLAKKLAIATIILDFAKAAIPLLTLKFLHYDQALLWSVAVLAILGHCFSIYLLFEGGKGIATGAGAMIVLLPLEVLTAFIVWVVIGKIFKISSLASLAALLAFVVSSFIFNYDLEIHTHAPVFIIAFIIVYKHLPNIKRLIFKEECKVI
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXB_MARN8
Sequence: MLIVADENIPLLDSFFGDIGEIRRVNGRTLTPDQVKDADILLVRSVTRVDRQLLEGTRVRFVGTATIGTDHIDQTWLQEQGIGFAAAPGCNAVSVAEYVLSVLSLYAEKRGIEDWSSLTVGIVGVGNVGGELARMLERLDFTVKLCDPPRQEAEEERAEEFVPLAEALECDVVTLHTPLTRTGDHPTNRMIAGSELAALGQDQLLINAGRGEVIDGEALLARLQQADAPTVVLDVWEHEPRINPDLLDRVWLATPHIAGYSLEGKMQGTEMIYQALCRYLGLPVRKKAGQFLPEPALSKVSFTSSADEDEAVQVALRACYDPRRDDARLRLTMRGNPEERAQAFDRLRRDYPVRRECSSLKVQLKGSSKSIQDSFRAIGFKLKI
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_AKOJU
Sequence: MKVLRKNHPLLKIVNHSFIDLPTPSNISSWWNFGSLLGTCLVIQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYILSETWNIGIILFLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALALVHLLFLHETGSNNPSGLNSDSDKIPFHPYYTTKDLLGIFLLLLVLMILALFFPDVLGDPDNFTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAAFPLLNTSKQHGLIFRPVTQVIYWIFIANLLVLTWIGGQPVEYPFTMIGQIASITYFTIIIILMPVSNTIENNIIKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HIS7_METC4
Sequence: MRTASISRRTAETDVSVSIDLDGTGKATIATGVGFLDHMLELFARHGLFDVTIKVEGDLHVDQHHTTEDAGIALGQAVAQALGDKRGIARYADIHLPMDETLSRIAIDISGRPFLVFRTSFRVEKIGQFDTELVREFFQAFAMNAGITLHVETLYGENAHHIAESVFKGLARSLRKAVAIDPREDGRVPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIP_HYAAS
Sequence: MNYLCLVVTLVAVAGAISGEKFSDDNTGYQSTPSLRIRTTPGRRRQTPRTIGPPYTRRTLRTTTDYSTTVENGNLTTPAANSTEKGNGLYGLRRQTPRTIGPPYTRRTLRTTTGYWTTVEKGNGTTPAANSTEKGNRPYGRRRQTPRTIGPPYTRRTTTDYWAAVEKGYLTTPAANSTEKESRPNATQRREISWTFGPLYTWRTTKGYGTTLETTNATSTS
What is the function of this protein?
Not studied but probably similar to Hyalomin-B1.
What are the official names of this protein?
Immunoregulatory peptides, Anti-inflammatory peptides.
What are the subcellular locations of this protein?
Secreted.
Protein: MURC_HERAR
Sequence: MKHKVKNIHFVGIGGSGMSGIAEVLLNLGYTISGSDLGSNAATRRLVELGAKVTLGHAAENIASADAIVTSTAVQQDNPEVVAAREKHIPIVPRAMMLAELMRLRRGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGLLNSAGANAKLGAGEFIVAEADESDASFLNLSPVIEVITNIDADHMETYEHDFEKLKQAFVEFTQRLPFYGVAVLCLDDATVREIMPRISKLITTYGFHEDAMVRAVDAKAVDGHMQFTVIQDGYAPMQVSLNQPGMHNVQNACAAIAIARELGVSDHATQKALTEFTGVGRRFTRYGEISFSAVNDKPAGSFALVDDYGHHPVETAATISAARGAYPGRRLVLAFQPHRYTRTRDLFEDFVKVLSTTDMLLLAEVYAAGEQPIVAADGRTLAHALRVAGKVDPVFVEHIVDMPATIMNIVRDGDVVITMGAGSISGVPAKLKQMQDQV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TECA2_CUPXP
Sequence: MLDSVKRADVFLRKPAPVAPELQHEIEQFYYWEAKLLNDRRFEEWFALLAADIHYFMPIRTTRIMRDARLEYSGTGEHAHFDDDAAMMKGRLRKVTSDVGWSENPASRTRHLVSNVMIADGPVEGEYEISSAFIVYRNRLERQLDIFAGERRDTLRRNKTETGFEIVNRTILIDQSTILANNLSFFF
What is the function of this protein?
Part of the oxygenase component of the chlorobenzene dioxygenase system that catalyzes the dihydroxylation of a range of aromatic compounds, including chlorinated benzenes and toluenes, and dinuclear aromatics such as biphenyl and dibenzo-p-dioxin (PubMed:9249026, PubMed:9791099, PubMed:11526005).  The beta subunit is not directly involved in the control of substrate specificity (PubMed:9791099).
What are the official names of this protein?
Chlorobenzene dioxygenase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: TFPI1_MOUSE
Sequence: MTYKMKKEYAFWATVCLLLSLVPEFLNALSEEADDTDSELGSMKPLHTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTCIPGYEKTAVKAASGAERPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICENPVHSPSPVNEVQMSDYVTDGNTVTDRSTVNNIVVPQSPKVPRRRDYRGRPWCLQPADSGLCKASERRFYYNSATGKCHRFNYTGCGGNNNNFTTRRRCLRSCKTGLIKNKSKGVVKIQRRKAPFVKVVYESIN
What is the function of this protein?
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex.  It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity).
What are the official names of this protein?
Tissue factor pathway inhibitor, TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_STACT
Sequence: MERTFLMIKPDGVQRKLVGEIITRLEKKGLKLVGGKFMTVSKEKAETHYGEHADKPFYEGLVSFITSAPVFAMVVEGENVVEVTRNMIGKTNPTEAAPGTIRGDLGLTVGRNVIHGSDSVESAKREISLWFEPNELSVYTANDEEWLYEN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_ANADE
Sequence: MAEISAKMVQELREKTGAGMMDCKKALTEAGGDLVKAEEVLRKKGLSAAAKKTGRAATEGAVASYIHMGGKIGVLVEVNCETDFVARTEGFQGLVKEIAMQIAAASPRWVRREEVPADVVAKELEIAKAQAREQKKPEAILEKIATGKVEKFYSEFCLMEQAWVKDDKKKIQDVLTDAVAKIGENIQIRRFARFVLGEGLEKKQENLAEEVAKAAGLQK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_CITK8
Sequence: MGKIIGIDLGTTNSCVAIMDGTTARVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPYKIIGADNGDAWLDVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEVGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRMINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDINDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTALISKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAESDRKFEELVQTRNQGDHLLHSTRKQVEEAGDQLPADDKTAIESALSALETALKGEDKAAIEAKMQELAQASQKLMEIAQQQHAQQQAGGADASANNAKDDDVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FLID_TREPA
Sequence: MSDVRIPGVGAGKYDNLIQSLMKKERIPRDNAAAKVKVYEVQNNALKDVERYARDLRDAVKGLYSFNNPFAEKEAHSSNERAFTVDATRDAAEQNHTLRVKDIAQGDAFLSDPLPEDFRVPSGTYTFCIGEKKICVSWKGGHYRDFIRAVNKQGKDSLTLSEIKTSGASRALLFRSELTGKSSRLSFEDAALDLALRLRVVQEARSDVFTQDVLSVGPGKHARLDFPHPLRAQAGLTLEFVASLEGASIANEESRAHTPAQGGAPTSSHGNTASAAHNQDGAAAVRPTEPANGAPVQEETSSVFFEGVTVKNEASQGDLPTTDGLEKYPAVDDKGDNPRAPGESQGTATHEGSGSSTDNADDTRSTGALAGSGKLALESLQGHALPLPPLVLTQNAPQMVSIPLREYGDVRALILDNAQARGALTLRAIRVRAEDAPGGYVPVNPASQAQDAAFDFDGVHVTRGTNSITDLIPGVTLSLHERTEKTETLSVTPDVNAMKNAIIEFVAKYNRLMAEINIVTSNKSAIIDELAYLTPEEKKKETEQLGSLHGDSTLLMLKDRLRRNTSNAYRAGDDGASRTLAHIGISTKAHASSGINTAQLRGYLEIDEEKLHSSLNAQKDQVRALFGHDSDGDLLVDNGVAFTLTELLNPYLGRSGIFAIRSNGVDERIKSTEKRVETYDKQLEKKERELRHKYHTMDGALRSLQKQSDAIQNFNQSVRNRN
What is the function of this protein?
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament.  Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
What are the official names of this protein?
Flagellar hook-associated protein 2, HAP2, Filament cap protein, Flagellar cap protein.
What is the protein family that this protein belongs to?
Belongs to the FliD family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: RRT15_YEAST
Sequence: MVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRYRLTDVPPQPNSPGEIYCFYINCIMNRR
What is the function of this protein?
Involved in modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 15.
What is the protein family that this protein belongs to?
Belongs to the ART2/RRT15 family.
Protein: HOLC_HAEIN
Sequence: MAKTAQFYILTENCTLTVEEIACNLAASIWRSGKKVLISCESEAQALEIDERLWQRDPNEFVPHNLSGEATQYPTPIEISWLGKRNLQRRDLLINLQQEIPDFSHSFTQIIDFVPKDDALKTQARERYKQLRLQGWNLSTENVG
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
What are the official names of this protein?
DNA polymerase III subunit chi.
Protein: DYR_UREPA
Sequence: MLKLIWCQTLNGGISKNNKLPWYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNIIFSSIMQTPEDESYFVTNDFQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: RSMJ_CROS8
Sequence: MNICLIDETGAGDGALSVLAARWGLTHDADNPMALVMTSARLELRKRDEPKLGGIFVDFVEGAMAHRRKFGGGRGEAVAKAVGIKGSYLPQVVDATAGLGRDAFVLASVGCHVRMLERNPVVAALLDDGLARGYQDAEIGPWLRERLQLIHASSLTALEAITPRPDVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLAPARRLAIKRVVVKRPDYAPPLGDVATPNAVVTKGHRFDIYTGTPA
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.