PharMolix/UniProtQA huggingface dataset:
Protein: LYS1_LYCSI
Sequence: RKGWFKAMKSIAKFIAKEKLKEHL
What is the function of this protein?
Antimicrobial peptide that inhibits many reference strains of bacteria and fungi (PubMed:23638903, PubMed:30269852).  Is potent against Candida species and multidrug-resistant Acinetobacter baumannii (MDRAB) (PubMed:25199777, PubMed:30269852).  Is probably localized in the cytoplasm after being transported through the cell wall and membrane (PubMed:30269852).  Is able to interact with cell membranes and enter into cell plasma to activate the mitochondrial death pathway to sensitize cancer cells for apoptosis, as well as up-regulates p27 to inhibit cell proliferation (PubMed:22882120).  It shows very low effect on normal cells, such as erythrocytes, Hek293t cells (PubMed:22882120).  It also potently inhibits tumor cell growth in vitro, and suppresses various tumor growth in vivo when tested in human cancer xenograft models (PubMed:22882120).  It interacts with the cell membrane and is then internalized into the cytoplasm of cancer cells to initiate the programmable cell death (PubMed:22882120).  In addition, this peptide has the therapeutic effects of anti-hypertension by endothelium-dependent vasodilatation via the NO/sGC/cGMP signaling pathway (PubMed:29248696).  In vivo, this peptide also shows a significant ability to inhibit T. gondii invasion and proliferation, making it a potential alternative agent for the treatment of toxoplasmosis (PubMed:30682337).
What are the official names of this protein?
Lycosin-I, Anticancer peptide, Cell penetrating peptide.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 05 subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Lipid membranes induce the formation of amphipathic-helix conformation of lycosin-I and subsequently stable aggregates of peptide molecules on bilayer, which are believed to be crucial for the cell penetrating ability of lycosin- I.
Protein: SECY_STRSV
Sequence: MFFKLLKDAFKIKQVRSKILFTIFIILVFRIGTTITVPGINAKALSNLNDLPFLNMLSLVSGNAMRNFSVFALGVSPYITASIVVQLLQMDLLPKFVEWGKQGEVGRRKLNQATRYIALVLAFVQAIGITAGFDTLSRANLVANPNVQTYALICVLLATGSMIVTWLGEQITDKGYGNGVSMIIFAGIVSAIPDMIKGIYEDYFVNIPSERLTSSFIFVGILIVAVLLIIYFTTFVQQAEYKIPIQYTKVAKGAPSSSYLPLKVNPAGVIPVIFASSITAAPAAIFQVVSALGYDADWVKTAQSLLATTTISGMFMYAFLIVLFTFFYTFVQINPEKTAENLQKSGAYIPGVRPGKGTEDYMSKLLRRLATVGSLFLGFISILPILAKDVFGLTDAVALGGTSLLIIISTGIEGMKQLEGYLLKRKYVGFMDTSE
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYK_METH1
Sequence: MERKLSEQEEIRRNKIAELEKNNLQAFHKTIKPTANSKELNEKYKNLSREDLDKQNLEFVFNGRIMTIRGPFIVLQDNCGQMQIYANKKTLNESSAKTFSLMDFGDILSVRGTLSKTNTDALVIKAQDIVLLTKSLKPLPDKFHGLVDPEERRRQRYVDLIMNEKTRNTFVMRTQIIKGIREYFDSLNYIEVDTPILNPILGGAAAKPFITFYNALNRNFYLRIATELPLKKLIVGGLDRVYEIGRIFRNEGVDTTHNPEFTSIEFYEAYSDLWGMMERTEGVFKHLINKFNIKEVKFNGFDITFNFPFKRVNMIDAISEKINVDIRKLNEEQMFELAKKHGIKIEKFFRYGHIINELFEKYVEETLIEPTFVYGHPIEISPLAAIDPDDKRFTLRAELFIGTKEFANMFTELNDPIDQLQRFENQLLEKENGNEEANEIDWDFVNALEYGMPPTGGSGIGIDRLIMLLTQNDSIRDVVLFPQLKDLK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 11S3_HELAN
Sequence: MASKATLLLAFTLLFATCIARHQQRQQQQNQCQLQNIEALEPIEVIQAEAGVTEIWDAYDQQFQCAWSILFDTGFNLVAFSCLPTSTPLFWPSSREGVILPGCRRTYEYSQEQQFSGEGGRRGGGEGTFRTVIRKLENLKEGDVVAIPTGTAHWLHNDGNTELVVVFLDTQNHENQLDENQRRFFLAGNPQAQAQSQQQQQRQPRQQSPQRQRQRQRQGQGQNAGNIFNGFTPELIAQSFNVDQETAQKLQGQNDQRGHIVNVGQDLQIVRPPQDRRSPRQQQEQATSPRQQQEQQQGRRGGWSNGVEETICSMKFKVNIDNPSQADFVNPQAGSIANLNSFKFPILEHLRLSVERGELRPNAIQSPHWTINAHNLLYVTEGALRVQIVDNQGNSVFDNELREGQVVVIPQNFAVIKRANEQGSRWVSFKTNDNAMIANLAGRVSASAASPLTLWANRYQLSREEAQQLKFSQRETVLFAPSFSRGQGIRASR
What is the function of this protein?
This is a seed storage protein.
What are the official names of this protein?
11S globulin seed storage protein G3, Helianthinin-G3.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
Protein: RL34_HYPBU
Sequence: MPRPHQRTRSLRRVYVRTPGGETKIHYEKRRPGPARCAICGRPLNGVPRLRPVELRKLPKTAKRPERMYGGVLCAECLEKLLKKSIRSQVLAQLEQLRRSVAAGQS
What are the official names of this protein?
50S ribosomal protein L34e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: RHG_RAT
Sequence: LFEENGGAL
What is the function of this protein?
May keep Rho-GTPase in a GDP-bound form.
What are the official names of this protein?
Rho-GTPase-activating protein.
Protein: IMQJ_ASPFN
Sequence: MVNQAFMLWCYITPVLGAVVAEQYIGRVKTIIFSSSVYLCGLVTLFLSSLPTAYAMGISLPGLLVSLFLIGIGTGGIKTNVSSLIAEQYTGPKESRRILKSGEEVIVDRDLTIQRIFTTFFLYINIGSFSPLLITIIEKEYGFSAAFSLSAITFSIGFIIVLVSRHLYISRDPDSSIIFNACKAFWIAIKHKGNLDYARPSYQTEQAATRRLSWDDSFIDDLRRAIASCKIFILYPIYWAAYSQFLTNFISQAATMETHGVPNDIMTNIDPITVLILLPVLDRIVFPFLRRQGVPVRHVDRITIGMPDFQPFVQESYQICQRTCFQIISAIELGLGLQAGRLTQCCQPAASEIRLLYYPPTTKNLFDEGLKKRAWPHTDLGIITLLFQDMVGGLEVEDRAAGKPRSFIPVKRVSPNEMIVNTSDSLQRWTNNVIRAGLHQVTAPDAAKLSNGVDMLPARCSSVFFFKAGRDTSVGPLPEFVTEDRPAAFEDMTALQYQQLKTRILHGVEG
What is the function of this protein?
Peptide transporter; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination (PubMed:29182847).
What are the official names of this protein?
Peptide transporter imqJ, Imizoquin biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CRTB_SYNY3
Sequence: MANGQISPQRAVTKPQSWWLTSEPRPSLMLQLPKPSPSAKPCASVEEAYEICRQVTAQYAKTFYLGTLLMPPAKRRAIWAIYLWCRRTDELVDGPQAATTTPETLDHWERRLEGIFAGQPQDDADVALVDTLETFPLDIQPFRDMIAGQRMDLYRSRYQTFEELDLYCYRVAGTVGLMSSAVLGVDTGNGQAPWQPDAVYIPQEEAIALGVANQLTNILRDVGEDVERGRIYLPLEDLERFNYSEQDLLNGVNDDRWRSLMKFEIDRARHYFEDAERGIRALNRDARWPVWTALMLYKGILDVIEANNYNVFNRRAYVPTPKKLLYLPVAWLRAQVL
What is the function of this protein?
Involved in the biosynthesis of carotenoids.  Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield 15-cis-phytoene.
What are the official names of this protein?
15-cis-phytoene synthase, PSase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
Protein: PUR8_YEAST
Sequence: MPDYDNYTTPLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEITDDEIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKGTTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKMATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKFVQKDVNNALQPFQKYLNDEQVKLNV
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: IPYR_CORGL
Sequence: MSIEVTVEIPKGSRNKYEIDHETGKVYLDRYLFTPMAYPLDYGYIDHTLGEDGDPLDALVILPESVFPAVVVKSRIIGVFKMTDEAGGDDKLLSVLDDPRYDHIQDISDVSDFLKDEIEHFFVHYKDLEKGKHVDGSGWGDKAEAEKIHAEAIDRYKA
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_BACC7
Sequence: MYLINQNGWIEVICGSMFSGKSEELIRRVRRTQFAKQHAIVFKPCIDNRYSEEDVVSHNGLKVKAVPVSASKDIFEHITEEMDVIAIDEVQFFDGDIVEVVQVLANRGYRVIVAGLDQDFRGLPFGQVPQLMAIAEHVTKLQAVCSACGSPASRTQRLIDGEPAAFDDPIILVGASESYEPRCRHCHAVPTNKDK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGB_SALTY
Sequence: MLDRLDAALRFQQEALNLRAQRQEILAANIANADTPGYQARDIDFASELKKVMVRGREETGGVALTLTSSHHIPAQAVSSPAVDLLYRVPDQPSLDGNTVDMDRERTQFADNSLKYQMGLTVLGSQLKGMMNVLQGGN
What is the function of this protein?
Structural component of flagellum, the bacterial motility apparatus.  Part of the rod structure of flagellar basal body.
What are the official names of this protein?
Flagellar basal body rod protein FlgB, Putative proximal rod protein.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: ATPA_NEIMB
Sequence: MQLNPAEISDLIKAKIENLSVNAEVRTCGTVISVTDGIVRIHGLSDAMQGEMLEFPGNTFGLAMNLERDSVGAVVLGEYEHIKEGDTVTCTGRILEVPVGRELVGRVVDALGRPIDGKGPINTTLTAPIEKIAPGVIARKSVDQPMQTGLKAIDSMVPVGRGQRELIIGDRQTGKTAVALDAIVNQKGTGVICIYVAIGQKASSIANVVRKLEEHGAMEHTIVVAATASEAAALQYIAPYSGCTMGEFFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNEHEVEKLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAINAGISVSRVGGAAQTKVIKKLGGGIRLALAQYRELAAFSQFASDLDEATRKQLEHGEVVTELMKQKQFSTLNTAEMALTLWAINNGSYSDVPVAKALAFESEFLSFVRTQHPEVLEAVNASGAMSDESEKTLEAAMKSFKSSYAYQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MNMG_POLAQ
Sequence: MRYSKNFDVIVVGGGHAGTEAALASARMGCDTLLITHSIENLGAMSCNPSIGGIGKGHLVKEIDAMGGAMAAATDEAGIQFRILNSSKGPAVRATRAQGDRVLYKAAIRRRLENQPNLSLFQAAVDDLLVKGDEVQGVVTQMGLEFMAKKVVLTAGTFLDGKIHVGLNNYAGGRAGDPAAVSLSARLKELKLPQGRLKTGTPPRIDGRTIDFSVMLEQPGDLDPVPVFSYLGRPEQHPKQVPCWISHTNEQTHDIIRGGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASRNSHQIFLEPEGLTTNEFYPNGISTSLPFDVQWELVRSIRGLESAVIVRPGYAIEYDFFDPRHLRHSLETKAIGGLYFAGQINGTTGYEEAAAQGMLAGINAGLAAQGKEAWLPKRSESYIGVLVDDLITRGVQEPYRMFTSRAEYRLSLREDNADMRLTAIGRDLGLVDDYRWEVFCRKQEAVSRETSRLKDIWVGPKHEIAPLVTQLLGQELSHECNLTELLRRPGITYEAITALGNRIWAPESLDDDLGLAAQISDQVEISVKYQGYIERQAVEIARQEHNETFPLPEGLDYSQVLGLSKEVQQKLNLHKPETLGQAGRISGVTPAALSLLLVHLKKGLGRTQETI
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_PHOLL
Sequence: MINTPRVSIQVQSVYVESQSCPDQRRFVFAYTITIRNLGRERVQLINRYWLITNSDSHQTEVQGEGVVGEQPIIQPGTEYRYTSGAILETPLGTMEGHYEMIDHNGEPFRVAIPVFRLAIPTLIN
What are the official names of this protein?
Protein ApaG.
Protein: HYPDH_HUMAN
Sequence: MSPRVVSNSSVLASQSVGITNVRTVFSNVFNNTTAFPILRGSNCHKITAPGLGKGQLVNLLPPENLPWCGGSQGPRMLRTCYVLCSQAGPPSRGWQSLSFDGGAFHLKGTGELTRALLVLRLCAWPPLVTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH
What is the function of this protein?
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor.  Can also use proline as a substrate but with a very much lower efficiency.  Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline.  Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.
What are the official names of this protein?
Hydroxyproline dehydrogenase, HYPDH, Kidney and liver proline oxidase 1, HsPOX1, Probable proline dehydrogenase 2, Probable proline oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the proline oxidase family.
Protein: HEM1_TROW8
Sequence: MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGDQDDVCKTGLLVQNRIGELCNISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIAGQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKINEVGQSLVSLSLDLASSRIGDWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALSGCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDLGLPRNFDPAISDLPTADLIDLDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEATPVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIHIPLTRCKQLAANGESHKFAESMEILFDVKTDCTEGTQYQSSCGKSFD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: UNG_STRZJ
Sequence: MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWGAYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_STRCO
Sequence: MAASRNASTANTNNAASTAPLRISFAKIKEPLEVPNLLALQTESFDWLLGNDAWKARVESALESGQDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPKNSIDECKDRDFTYAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVVVSQLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRIDRKRKQSVTVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDIYRKLRPGEPPTREAAQTLLENLYFNPKRYDLAKVGRYKVNKKLGADEPLDAGVLTTDDVIATIKYLVKLHAGETETVGESGREIVVETDDIDHFGNRRIRNVGELIQNQVRTGLARMERVVRERMTTQDVEAITPQTLINIRPVVASIKEFFGTSQLSQFMDQNNPLSGLTHKRRLNALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLASYGRINPFGFIETPYRKVVEGQVTDDVDYLTADEEDRFVIAQANAALGDDMRFAEARVLVRRRGGEVDYVPGDDVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMMRQAVPLIKSESPLVGTGMEYRSAADAGDVVKAEKAGVVQEVSADYITTTNDDGTYITYRLAKFSRSNQGTSVNQKVIVAEGDRIIEGQVLADGPATENGEMALGKNLLVAFMPWEGHNYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVSEEVLADLDERGIIRIGAEVVAGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGEIGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKITDGDKLAGRHGNKGVISKINPIEDMPFLEDGTPVDIILNPLAVPSRMNPGQVLEIHLGWLASRGWDVSGLAEEWAQRLQVIGADKVEPGTNVATPVFDGAREDELAGLLQHTIPNRDGERMVLPSGKARLFDGRSGEPFPEPISVGYMYILKLHHLVDDKLHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQSLCLNVEVLSSDGMSIEMRDTDEDVFRAAEELGIDLSRREPSSVEEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: AROB_CAMFF
Sequence: MKIDINLNDDNKNYSVFIDELKNLKFKGKVAVITNSKVGGLYLGEILNLIDADEIFSVCIPDGEQYKNLAMIEYILEQLFVSRLERNSTLIALGGGVISDMTGFAASIYERGINFINIPTTLLAQVDASVGGKTGVNNKFGKNLIGTFYQPKAVYCETKFLNSLPNREFNAGMAEVIKMATMFDKDFFKFIQDNSVENSQILKQIIAKCVEIKAGVVAKDEKESGIRAVLNYGHTFAHVIEMQTNYKKFLHGEAVAIGINMANHLACKLGLLSKKDLDIIEQTLIKFGLPTTYRISDEEVFYDSFFLDKKSENKKIKFILPNGIGSYALRNDIDKNSVLDILRMFK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_MYCGA
Sequence: MASITELIKQLRASTQAGFMDCKKALEATNNDIDQAIKWLRENGIAKAAKKVDNVASEGVIKLKLADQKATILEINSQTDFVTKNDQFVAFSNELVDLVHKHETTDVAKIEQLKLASGSTVAETQIHLTAIIGEKISLRRVAFVKEEANSSLATYLHSNSRIGVIVKTSKTDDKEFLKHLAMHIAASNPKFVSQKDVSADFIAKEREIAAAQAQSENKPKEFIDRIVDGRINKVLEEVCLVNQKFLVNQEQTVQQAAQAKKVEILSFIRYEVGEGIEKQVSNFADEVKAQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATD1_HUMAN
Sequence: MPLGLKPTCSVCKTTSSSMWKKGAQGEILCHHCTGRGGAGSGGAGSGAAGGTGGSGGGGFGAATFASTSATPPQSNGGGGGKQSKQEIHRRSARLRNTKYKSAPAAEKKVSTKGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLSSPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPFPTVPTRPEKGYIWTHVGPTPAITIKESVANHL
What is the function of this protein?
Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
What are the official names of this protein?
GATA zinc finger domain-containing protein 1, Ocular development-associated gene protein.
Protein: SPP2_ASPFU
Sequence: MSSSESPKDGKPSSKPFSLSLSGSGSNGRSRKSAFNIPPARAAEPPSRTLARRPHRLHDDESDEEEAPPAFEDVAGFDTHTGTVLSADGRAVDKEKRELVIPVTSKNNWRDRVRANRGTRGKNLLPKEVQAMQEAERRGETAENDQETDRPSMSYGLSFAKPSQGEETKPGEDQAMKDAGPLKPQVVDERKPLTQDEIALQALIRESKGETEGRTDLVIESAKREVDESYPVRLDETGSFRVDVASRPEPATLDQYNAIPVEEFGAALLRGMGWKEGQSIGRGKYGTSATDYRSQSPRIPERRPGFLGIGAKDVSGGKGAEAELGAWGRAAMRKGARKAETQGGEGNTQGVYMPVLMRNKKTGEYITEEELTALKKEGKAKKGDDDWRERRDRNLEKSGRMDILVAETITTMTAIGLTDGGRVLHGETEVCHPVIDSPGGESTTMKTAAGETTVIIATEIETETGAIVSGIKIETGIGIERGVVTGAADIGMMIGIARDIHPLMRLAGTDVIETAIETLNGEDMMINVSENAGQCFGLDRT
What is the function of this protein?
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor spp2.
What is the protein family that this protein belongs to?
Belongs to the SPP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LMIP_BOVIN
Sequence: MYSFMGGGLFCAWVGTILLVVATATDHWMQYRLSGAFAHQGLWRYCLGTKCYLQTESIAYWNATRAFMILSSLCATSGIIMGIVAFAQQPTFTRLSRPFSAGIMFFASTFFVLLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVALLMTFFAGIFYMCAYRMHECRRLSTPR
What is the function of this protein?
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization.  Acts as a receptor for calmodulin.  May play an important role in both lens development and cataractogenesis.
What are the official names of this protein?
Lens fiber membrane intrinsic protein, MP18, MP19, MP20, MP21, MP23.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GLMS_CHLTR
Sequence: MCGIFGYLGEKNAVPLVLEGLSKLEYRGYDSAGIATLVEGRLFVEKAVGPVSQLCSAVSSDIHSQAAIGHTRWATHGEPSRFNAHPHVDMDASCALVHNGIIENFQKLKEELEEQGVVFSSDTDTEVIVQLFARRYKETRDLIQSFSWTLKRLQGSFACALMHQDHPEVLLCAAHESPLILGLGEDEVFISSDIHAFLKYSGCTQTLASGELAVLRIGKSIETYNFELARIQKEVRCIDHTEDSLDKKGFDYYMLKELYEQPEVFERILHLTCEENGFTESFLKGFSLDEIQSLHIVACGSSYHAGYLAKYVIESIASIPVYVETASEFRYRQPYIAEHSLAILISQSGETADTLAALNEFRKLSKARVLGICNVRESALASRVDHCLFIEAGLEVGVASTKAFTAQLLLLILLGLRLANHRQVIAQEDLAQAIQGLKDLPNLTRLFLDSSIHDWRCRQIEETSFIFLGRRFMYPICMEAALKLKEIAYVEANAYPAGEMKHGPIALIREGTPVIVYCGDRSVYTKTIGAIMEVKARKAYVIALAPESNRDIAAVSDEQIYIPDSHDLAAPILFTIAGQIMAYTMALQRGTEVDRPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.