PharMolix/UniProtQA huggingface dataset:
Protein: APOE_AOTNA
Sequence: MKVLWAALLIALLAGCQGKMEQVVEPELEPEPELHQQADWQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLAQYRSEVQAMLGQSTDELRARLTSHLRKLRTVSYTHLDVYKRQSLASQPLQERAQAWGERLRTRMEEVGSRTRDRLDEVKEQVEEVRAKLEEQAQQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASAAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: LEUD_GLAP5
Sequence: MAKEFKQHTGLAVPLDASHVDTDAIIPKQFLQKVTRVGFGAHLFHEWRFLDDEGKQPNPDFVLNFPRYQGASILLARENFGCGSSREHAPWALDDYGIRAIIAPSFADIFYGNSLNNQMLPVRLSEEEVDELFKYVEANEGATITVDLEAQTVSANGKTYHFEIDSFRRHCLLNGLDNIGLTLQHEEKIADYESKIPAFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TI214_LOTJA
Sequence: MIFQSFILDNLVSLCLKIINSVIVVGLYYGFMTTFSTGPSYLFLLRAHVMEEGTEKKISATTGFITGQLVMFISIYYAPLHIALDRPHTITVITLPYLLLYFLGNNQKNFLNYVYKNQNSIRHFSIQRIFFQNLFFQLLNPFFLPSSILMRLANIYIFQSNNKVLFLTSSFVGWLIGHVFFMKWIGLMLVWIQEKNNSIKSTVAIRSNKGVLAKFRKSMFQIFLIFFFITCLYYLGRIPPIYFFTPKMSEIKERGEIEKREGEIDIEINSQRAGSKQEQKITAEEKLSPYLFSKKNNNLDKIKEENDIFGFQKPLVTILFDYNRWNRPLRYIKNDRFENVVRNEISQFFFFTCQSDGKERISFTYPPNLSTFQKMMEMKISLFTRDIISYEELSNSWRSTNEEKKKKLTNEFLNRVEVLDKESLPVDIFENRIRLCNDEKKQKYLTKEYDPFLNGPCRGQIQKWFSPPIQKETYKKNSLFINKIHGILFSNTNNYPKFEQKKNIFDRKSLLTDINFFFNLITKFSRKSVSSLNFEGLYLFPKDNKGKMSSKKKKFLFDTIRPDLNDNKIVNLQKCIGINEIVKKLPRWSYNLIDELEQLEGKKKVEYHQIRSRKAKRVVLLTKNSQNDDNYDETTDTDNTEKKKELALIRYSQQPDFRRDIIKGSIRAQRRKTVTCKLFQRSVDSPLFLEKMEKTSFFCFDILDSSKIFFMFKNWIRKKKELKNSDYTDEKAKESQKKEEEKIKKNEKEEKRRIEIGEAWDSIIFAQVIRGCLLITQSILRKYILLPSLIITKNIVRILLFQFPEWSEDFRDWQREMYIKCTYNGVQLSETEFPKKWLTDGIQIKILFPFRLKPWHRSKLRFTEKKKDPLKNKKVKKKNFCFLTIFGMEVELPFSGYPRNRFSFFDPILKELKKKMKKLKNNFFLILKIVNERTKNFITTLKETSKRIIQSILKKVLFLNKKIKKLYNYLFLFRFKKIDELNQNKKNFPITKNNPIIYESTILIQAINKTNCSLTEKKIKAINAKTKKIIKKIERMTKENKGGFLISEINSNSKKTSSNTKGLELEKKILQILQRRNVQLTHKLYSFFKFLLNFMKKVYTDIFLCIVSVPRINVQFFLESTKKIINQSIYNKKTNEEIIDKTNQSIIHFISIINKSSNTKNTNSAANSYEVSALSQAYVFFKISQIQVLNVYKYKFKYVFDYDGRSFFIKDEIKDYFFGIQGIIHSKLRHKNSPVSLKNQWTNWLKVHYQYDLSQNRWSRLVQKNLKNRINKHRLDQNKDLTKCDSYKKTQLIVSKNKKQQVDFLVNLLIQKKIKKQSRYDLLLYKFINYAEKKELSIYGYRSPFQANKKRAISYDYNTQKKEFFDRMDDISIKNYIAEDAIRYIEQNRDRKYFDWVVMDVKIQNNSISNLQFSFFFKFLRFYDAYRNKPWIIPIKFLFLHFSVNQNFNKIKNIIEKKRRIDIFKPWKKKKILEVELETPNRAKKEYTSRVDLNKPSLSNQEKDIEEDYGESDSKKGGKDKNKKKYKNKIEAEVNLLLRKYLNFHLNWKGSLNKRVINNVKVYCLLIRLKNIKQIAISSIQRGELSLDIMMIQNEKDSTLTGFRKKKEFIEKGIFIIEPVRLSRKNNEQFFMYETARLLLIHKSKRQINQRNPEKSDLDKQIFYKNIPPKRDQRITQNKEKKHYALVVIENILSARRRRELRILICFNPRSINSMPRKTIFDNENKINNCCQVFAKNKDLDKEKKILMNLKLILWPNYRLEDLACINRYWFDTYNGSRFSIVRIHMYPRLKMR
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: Y2146_BRADU
Sequence: MGRFEGKVAVVTGAGAGIGKACALAIAREGGRVVVADIDGSAAIACTAQIAAEAGHALALAIDIADAQAVAALFETAERHFGGVDLLVNNASAMHLTPRDRAILELELAVWDQTMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSCQGLSGDTALTSYAASKAAMNMLSSSLATQYGHAQIRCNAVAPGLIMTERLLAKLDACMQTHLRRHQLLPRVGRPEDVAALVAFLLSDDAAFITGQVVCIDGGMLAHVPTYADGGNSRAARPAGETAEADAAPRC
What are the official names of this protein?
Probable short-chain type dehydrogenase/reductase blr2146.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PLSX_PELTS
Sequence: MKIAIDAMGGDYAPREIVKGALLAAEQYRLNIILVGDEEQLRAELGRSNAGGLVNIVHAPEVIEMREHPAVAVRRKKNSSIVKATQLVRDGEASALVSAGSTGAAMAAALFGLGRIKGIDRPAIAGVLPNEKGLTVLLDAGANVDCKPYHLLQFGVMGYLYAKKIFGITCPRVGLLSNGEEETKGNEVTLAAYHLLQKAGINFVGNIEGRDLFNGNVDVAVCDGFVGNVVLKAGEGLAGALFKIMKEEISKSWLAKIGTVMAEPALKGFKSRLDYAEYGGAPLLGVNGISIICHGSSTAKAVKNAIRVARESVENRLLEDIRSSIESIEVKGAGGNLVQEID
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: CAP1_BOVIN
Sequence: MADMRNLVERLERVVGRLEAVSHASDTHCGYGDSAAKAGTTPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVVTFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSRTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGLIRSGPKPFSASKPDPPKPVAKKEPALLELEGKKWRVENQENVSNLMIEDTELKQVAYIFKCVNSTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHVYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG
What is the function of this protein?
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
What are the official names of this protein?
Adenylyl cyclase-associated protein 1, CAP 1.
What is the protein family that this protein belongs to?
Belongs to the CAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AIR9_ARATH
Sequence: MEEVAAKVEEETVETNVDAVKEDNATIANESRSPESVSAVSVVSNRAASTKKKPVISSNLIKPTASSSLRVSGTTPVTIRRNSTGGVTENLAGTSKVLPKQVSTTASRTDPVRRSLPELRKSSVSSLSAKTVSKPSLSESKKSVPVSPGSRSLTKSTGFSLSKPESSARPAMSVSVSSKRAPSSSVDSSGSRTSSGRLHSTLTSGRTVSKVSSPSAGSSPSVSSSIRSKSFSSPLDRTSNFSGRKKTSTPESRDSRLIILPKVEVKAGDDMRLDLRGHRIRSLTSGGLHLSPNLEFVYLRDNLLSTLEGIEILNRVKVLDLSFNDFKGPGFEPLENCKMLQQLYLAGNQITSLASLPQLPNLEFLSVAQNKLKSLAMASQPRLQVLAASKNKITTLKDFPYLPVLEHLRVEENPLLKISHLEAASILLVGPTLKKFNDRDLSREEVAIAKRYPPQTALCLREGWEFCKSDLAAESTFRFLVERWKDTLPSGYLIKEAHVDRPSEEAPCQCHFGLFQESPTATDQELALKFQWSVADRSLSNFVPILNATKEVYWPKREDIGKILKIECTPVMAETEYPSIFAISSPVQRGKGIPKVVSLELNGELVEGNIIKGQAVVAWCGGTPGKCITSWLRRKWNGSPVVIDGAEDEEYMLSLDDVGSSMVFMYTPVTEGGARGEPQYKYTEFVKAAPPSVSNVRITGDAVEGCVLKGVGDYFGGKEGPSKFEWLRKNKETGELSLISAGTSEYTLTQEDVGTHVTFVYIPANFEGLEGEPVSTSSSVVKPAPPKVTDAKIVGDLRENSKVTVTGTVTGGTEGSSRVQWFKSSCSILEGDNSLEELSTSKVAKSFRIPLGAVGYYIVAKYTPMTPDGECGEPVYVLSERAVETLPPSLNFLSITGDNIEGGILTASYGYIGGHEGKSKYEWHYHKAENDLPGALIPEASGLLQYTITKEAIGKFISFQCIPVRDDGIVGEPRSCMSQERVRPGNPSTVSLHVVGALVEGTMLSAEKEYWGGEEGASVFRWFRTNSDGTPCEIKGATTSSYLLSVGDIGYFISVSYEPVRNDRARGPTAISEIAGPIVAGHPNCQSLEFLGSMIEGQRLSFVASYTGGMKGNCYLEWVRVKNNGVKEILSSDEFLDLSLDDVGESIELIYTPVREDGIEGSPRSIRTDGIAPANPMGLELLIPDCCEKQEVVPHKTYFGGHEGVGEYIWYRTKVKLHGSALTEISYAGEEVVVCCRTLKYTPSLEDVGAYLVLYWIPTRVDGRSGKPVVVITNSPVAPADPEVSNVRVKKLFSDAYSGEGEYFGGHEGPSLFSWYRENDGTIDLIDGANSKTYEVTESDYNCRILFGYTPVRSDSVVGELKMSEPTEIILPEVPKVDMLAFTGKAVQGDVLTAVQVIPKTEIQQLVWSKYKGDIQYQWFRSPESGDKISYEALSSEISCSYKVRFEDIGRCLKCECVVHDVFGRSSELAYAETDPISPGFPRIEKLEIEGQGFHTNLYAVRGNYFGGKEGKSKIQWLRSMVGSPDLISIPGETGRMYEANVDDVGYRLVVVYTPIREDGVQGHPVSASTEPVAVEPDILKEVRQKLETGLVKFEVLCDKDPYPKKIVGEGNLERRMLEMNRKRIKVVKPGSKTSFATTEVRGSYGPPFHVETFRNDQRRLRIVVDSENEVDIVVQSRHLRDVIVLVIRGFAQRFNSTSLNSLLKIDT
What is the function of this protein?
Microtubule-associated protein that may be involved in the maturation of cell plates and proper insertion of cross-walls after cytokinesis.
What are the official names of this protein?
187-kDa microtubule-associated protein AIR9, Auxin-induced in root cultures protein 9.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, phragmoplast. Note=During interphase, binds cortical microtubules. In M-phase, locates to the preprophase band. During cytokinesis, binds the phragmoplast but not the forming cell plate at the midline, and at a later stage the cortical division site. After cell-plate insertion, enters the new cross-wall.
Protein: SYY_OPITP
Sequence: MTILDDLQWRGLYADCTDLAALTQRLGQGPVTLYCGFDPTADSLHVGNLVPLLALRRFQLHGHHPIALAGGATGMVGDPSGRSAERNLLTPDQVAHNIASIKQQLGRFLDFDATTNPARMVDNSTWTAPISFLEFLRDVGKHFSVNAMLAKESVRARLESESGISYTEFSYMLLQAHDFLHLRETMNCELQVGATDQWGNITAGTDLIRKKLGAPAWGLTFPLLTKSDGTKYGKSTSGAVYLDPKRTTPYRFYQFFVQAEDADVIKLLKVLTFLSAEEITALDTDLKANPGARAAQKALARAVTTLVHGDTECANAIRASEIMFGGGLDGISESLFQDVVGEIPTKELEAAKLSGAGAPLVELLVHAGLAPSKGQARKDIDGGGIYVNNARVGEASRAVTTGELLFGKYLLLRKGKRTYTVVKIV
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSU_ASPCI
Sequence: MTILDKRQIQRFASDTDIETLSKAIDDDGVAIVRSVVSRDVIQRLQKEVESSDQPVWLEDNPSLKDSKFPSQARHANNLVPASKTYRDDILNNSAVHTTCKAVFRDVGDYWLTTGILRTTKPGSPAQGFHRDALLYPVLQYQPPTSPPLTVALLVSMTDATVANGATRVILGSHKWETVGTPSEDQAVRAELDAGDMLVIHQRLVHAGGEHTHQAPDTRRMLLMFLTSCQLVALESPLALSRELVETMTPLAQKMVGWRTVRPVEPNTVGLNTHRSGCLEDGLKLRAAKPLEGQDGH
What is the function of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase ausU, Austinoid biosynthesis cluster protein U.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: SUCC_STAS1
Sequence: MNIHEYQGKAIFRSMGVAVPEGRVAYTAEEAVEKAKELDSKVYVVKAQIHAGGRGKAGGVKIAKSLSEVETYAKELLGKTLVTHQTGPEGKEIKRLYIEEGCDIQKEYYVGFVIDRATDRVTLMASEEGGTEIEEVAAKTPEKIFKETIDPVVGLAPYQARRIAFNINIPKESINKAAKFLVSLYNVFIEKDCSIVEINPLVTTGEGEVLALDAKVNFDDNALFKHKDIQELRDLEEEDPKEIEASKYDLSYIALDGDIGCMVNGAGLAMATMDTINHFGGNPANFLDVGGGATKEKVTEAFKIILGDENVKGIFVNIFGGIMKCDIIAEGIVAAVKEVELTLPLVVRLEGTNVERGKEILKESGLAIEPAATMAEGAQKIVKLVKEA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: OP163_ARATH
Sequence: MDPAEMRYLEEEDGPLMKTIKGSITGFGAGTIYGTILATWKDVPRVERNVALPGLIRTLKMMGTHGLTFAAIGGVYIGVEQLVQNFRSKRDFYNGAIGGFVAGASVLGYRARSIPTAIAAGATLAVTSALIDSGGQTTRVDNGREYYPYTVEKRAEADS
What is the function of this protein?
Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars.  Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB (By similarity).
What are the official names of this protein?
Outer envelope pore protein 16-3, chloroplastic/mitochondrial, Chloroplastic outer envelope pore protein of 16 kDa 3, AtOEP16-3, OEP16-3, Mitochondrial complex I subunit B14.7.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family. Plastid outer envelope porin OEP16 (TC 1.B.30) subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DNAK_NEIMB
Sequence: MAKVIGIDLGTTNSCLAISENGQTKVIENAEGARTTPSVIAYLDGGEILVGAPAKRQAVTNAKNTIYAAKRLIGHKFEDKEVQRDIESMPFEIIKANNGDAWVKAQGKELSPPQISAEVLRKMKEAAEAYLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAFGMDKGDNKDRKVAVYDLGGGTFDISIIEIANLDGDKQFEVLATNGDTFLGGEDFDQRLIDHIIAEFKKEQGIDLKQDVMALQRLKEAAEKAKIELSSGQQTEINLPYITMDATGPKHLAMKITRAKFESLVEDLITRSIEPCKIALKDAGLSTGDIDDVILVGGQSRMPKVQEAVKAFFGKEPRKDVNPDEAVAVGAAIQGEVLSGGRSDVLLLDVTPLSLGIETMGGVMTKLIQKNTTIPTKASQVFSTAEDNQSAVTIHVLQGERERASANKSLGQFNLGDIAPAPRGMPQIEVTFDIDANGILHVSAKDKGTGKAANITIQGSSGLSEEEIERMVKDAEANAEEDKKLTELVASRNQAEALIHSVKKSLADYGDKLDAAEKEKIEAALKEAEEAVKGDDKAAIDAKTEALGAASQKLGEMVYAQAQAEAQAGESEQANASAKKDDDVVDADFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y3909_CHRVO
Sequence: MESLSLSHHFLIAMPGMGDPLFAKSLVYLCEHGEHGAMGLIINKPSGIAMAQLFDQIDLPLDDEDTRTGLVYFGGPVQPDRGFVLHQPAGNWQSSLMVTDDIALTTSKDVLVAVSEGKKPEQLLISLGYAGWSAGQLEKEIADNGWLTVPAEPSIVFDLPYEERYDAAMALLGFDPSLLSSDVGHA
What are the official names of this protein?
UPF0301 protein CV_3909.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: METN_HELPY
Sequence: MVVELKNIEKIYENGFHALKGVNLELKKGDILGVIGYSGAGKSTLIRLINCLERPSSGEVLVNGVNLLKLKPKELQKARQKIGMIFQHFNLLSAKNVFENVAFALEIARWEKNKIKSRVHELLELVGLEDKMHFYPKQLSGGQKQRVAIARSLANCPDLLLCDEATSALDSKTTHSILTLLSGIQKKLDLSIVFITHEIEVVKELCNQMCVISSGEIVERGSVEEIFANPKHAVTKELLGIRNEHADKKSQDVYRIVFLGEHLDEPIISNLIKRFKIDVSIISGNIEELTTKDIGYLVVRFLGNTAETQRALEYLNALGLQVEKLKD
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NCB2L_HUMAN
Sequence: MSKDLKILCKDPALELSCYRDHQFSGRKFQQEKLLKESSTLNMGNLSFYTTEEKIHELFSRSDIRNIFMGLDKIKKTACGFCFVECHNRADAENAMRFLTGTCLDEWIICTDWDVGFREGQQYGRGKSGGQVRDEFREDFHSGRGGFGRQTQI
What are the official names of this protein?
Nuclear cap-binding protein subunit 2-like.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
Protein: SGBU_ECOLI
Sequence: MRNHQLGIYEKALAKDLSWPERLVLAKSCGFDFVEMSVDETDERLSRLDWSAAQRTSLVAAMIETGVGIPSMCLSAHRRFPFGSRDEAVRERAREIMSKAIRLARDLGIRTIQLAGYDVYYEDHDEGTRQRFAEGLAWAVEQAAASQVMLAVEIMDTAFMNSISKWKKWDEMLASPWFTVYPDVGNLSAWGNDVPAELKLGIDRIAAIHLKDTQPVTGQSPGQFRDVPFGEGCVDFVGIFKTLHKLNYRGSFLIEMWTEKAKEPVLEIIQARRWIEARMQEAGFIC
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate (Potential).  May be involved in the utilization of 2,3-diketo-L-gulonate.
What are the official names of this protein?
Putative L-ribulose-5-phosphate 3-epimerase SgbU, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: DNAJ1_CORDI
Sequence: MARDYYAILGVERDATDNEIKKAYRKLARKYHPDVNDTEEAAEKFSKISIAQEVLLDAEKRRIVDMGGDPMAQGGGDAGYGAGGGLGDIFEAFFGGGGGSRGPRSRVQPGSDALLRTTLTLEEAYLGTKKPITIDTAILCDRCEGTGSKSKSKPNVCSTCNGSGEIQQMQRSFLGNVMTSSPCPTCRGTGEVIPDPCDKCGGDGRVRTQRDLIVNVPAGIADGMRIRMAGQGEVGPGGGPAGDLYIEVMMQQHPVFQREGNDLHMSVHVPMVDAALGATTSVESLSGDAIDFEIPAGVQPAETIVIEGKGMPQLRGEGFGNMIAHVDVSIPTQLDEKSKELLNKLRDHRSDESSVRTADDSDDSLFGRLRNRFRR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 1.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_STRP4
Sequence: MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNEAFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGVFKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYIGLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKAGELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSFVRLFV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVA_ACIAC
Sequence: MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLLYGFGSAPERQAFRELIKISGVGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKTAERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYNDKEGTAALKALPKDVGVSEGIKLALKALAK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.