PharMolix/UniProtQA huggingface dataset:
Protein: ASSY_METPP
Sequence: MATILQHLPTGQKVGIAFSGGLDTSAALHWMKLKGALPYAYTAHLGQPDEPDYDEIPRKAMQYGAEKARLIDCRAQLVAEGLAALQAGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQTFIDELGGRAEMSAFMTQAGFGYKMSAEKAYSTDSNLLGATHEAKDLEHLSSGIRIVNPIMGVAFWRDEVEVKREEVTVRFEEGRPVALNGIEFADPVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLHIAYERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEVALELRRGNDYSILDTRSPNLTYQPERLSMEKVEDAPFSPADRIGQLTMRNLDIVDTRAKLGIYAKSGLLSLGSGAALARLQNDDPS
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSIB_SHIF8
Sequence: MARAVHRSGLVALGIATALMASCAFAAKDVVVAVGSNFTTLDPYDANDTLSQAVAKSFYQGLFGLDKEMKLKNVLAESYTVSDDGITYTVKLREGIKFQDGTDFNAVAVKANLDRASDPANHLKRYNLYKNIAKTEAIDPTTVKITLKQPFSAFINILVHPATAMISPTALEKYGKEIGFHPVGTGPYELDTWNQTDFVKVKKFAGYWQPGLPKLDSITWRPVADNNTRAAMLQTGEAQFAFPIPYEQATLLEKNKNIELMASPSIMQRYISMNVTQKPFDNPKVREALNYAINRPALVKVAFAGYATPATGVVPPSIAIAYAQSYKPWPYDPVKARELLKEAGYPNGFSTTLWSSHNHSTAQKVLQFTQQQLAQVGIKAQVTAMDAGQRAAEVEGKGQKESGVRMFYTGWSASTGEADWALSPLFASQNWPPTLFNTAFYSNKQVDDFLAQALKTNDPAEKTRLYKAAQDIIWQESPWIPLVVEKLVSAHSKNLTGFWIMPDTGFSFEDADLQ
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Binds glutathione.
What are the official names of this protein?
Glutathione-binding protein GsiB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FMT_PSEE4
Sequence: MRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSAVKALAVAHDIPVYQPQTLRNPEAQAELAALKPDLMVVVAYGLILPQVVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGTLHDRLAAMGPGAVVQAIAGLADGSLQGEVQDDTLATYAHKLNKDEARIDWNRPAVELERLIRAFNPWPVCHSTLDGESVKVLAANLSTGKGTPGEILSASKDGLVVACGDGALSLTRLQLPGGKALAFSDLFNSRREKFAGGKVLGQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: HTPG_ECO24
Sequence: MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPDLYEGDGELRVRVSFDKDKRTLTISDNGVGMTRDEVIDHLGTIAKSGTKSFLESLGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGEKPENGVFWESAGEGEYTVADITKEDRGTEITLHLREGEDEFLDDWRVRSIISKYSDHIALPVEIEKREEKDGETVISWEKINKAQALWTRNKSEITDEEYKEFYKHIAHDFNDPLTWSHNRVEGKQEYTSLLYIPSQAPWDMWNRDHKHGLKLYVQRVFIMDDAEQFMPNYLRFVRGLIDSSDLPLNVSREILQDSTVTRNLRNALTKRVLQMLEKLAKDDAEKYQTFWQQFGLVLKEGPAEDFANQEAIAKLLRFASTYTDSSAQTVSLEDYVSRMKEGQEKIYYITADSYAAAKSSPHLELLRKKGIEVLLLSDRIDEWMMNYLTEFDGKPFQSVSKVDESLEKLADEVDESAKEAEKALTPFIDRVKALLGERVKDVRLTHRLTDTPAIVSTDADEMSTQMAKLFAAAGQKVPEVKYIFELNPDHVLVKRAADTEDEAKFSEWVELLLDQALLAERGTLEDPNLFIRRMNQLLVS
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRP_SALDC
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPLTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: AROD_ECOBW
Sequence: MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: EFTU_BAUCH
Sequence: MSKEKFQRTKLHINVGTIGHVDHGKTTLTAAITAVLAKAYGGNALAFDQIDNAPEEKARGITINTSHVEYDTKNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVPYIIVFINKCDMVDDSELLELVEIEVRELLSQYEFPGENTPIIRGSALKALEHDVDWTSKIIELAEVLDSYIPEPKRAIDKPFLLPIEDVFSISGRGTVVTGRVERGILKVGEEVEIIGIKNTTKTTCTGVEMFRKLLDEGRAGENIGVLLRGVKRDDVERGQVLAKPGSIKPHTKFASEVYILNKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPIDVEMVMPGDNIKMIVNLIAPIAMDQGLRFAIREGGRTVGAGIVTDIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_PHOPR
Sequence: MTTITITRPDDWHVHLRDGDVLKDTVRDISRYMGRAIIMPNLIPPVIDTESALSYRERIIAQGPQGNFSPLMVIYLTDNTSAEEIHKAKASGHVYAAKLYPAGATTNSDSGVTSIDHIRPALQAMQEAGMQLLIHGEVTAHDIDIFDREKVFLETVLAPIVEQFPNLRMVLEHITTADAVEFVTNAGPNVGATITAHHLMFNRNHMLVGGIRPHFYCLPILKRNIHQDALVKAATSGNPKFFLGTDSAPHAQGRKESACGCAGSYTAHAAIELYAEVFEAADALDKLEAFSSFNGPDFYNLPRNTDTITLKKESWNVPETMAFGGDEVVPIRAGEAMLWKVI
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: ACE4_CAEBR
Sequence: MKPKLVFLPFLIFITVFIEESEAVHPVVLETKLGDIRGNEFFFLSKKIRTFFGVPFAEPPVEEFRFRKPREKKQWKKLFDATKPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWAPADAYNLTVMVWFFGGGFYSGSPSLSIYDGRALAATQHVIVVNINYRLGPFGFLYLDHPDAPGNMGLLDQQLALHWIRQNIVSFGGNPDKVSVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAKQKSEKLLELVGCNKTTVENSMSCLRLVSPEQLSLSTWNISLTYLEFPFVIVSRDKHFFGHLDARAALREGDFNRDVNLMIGMNKDEGNYWNIYQLPQFFDKAEPPELTRHQFDNLIDSTFSIQPDIIRSAAKYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFFLFLQICSTPNGSLKNPPKVFVYYFTQSSSANPWPKWTGAMHGYEIEYVFGVPLSYSKIYKRREQIFSRKIMQFWASFAKNGTPRLRVLKNSEHWPEFNEHNNYRWMQLRSGSNIRPIKRRKETECQFWRRVKDTEYTAYLTQEYSSSCHINSYRILLFIPFFFIFSAF
What is the function of this protein?
Rapidly hydrolyzes choline released into the synapse.
What are the official names of this protein?
Acetylcholinesterase 4, AChE 4.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Protein: AROE_PYRAE
Sequence: MYFAVIGAHVRGKSASPAMHTASFKALGINAVYIAVDVPKEELGCFAQIARLNFRGFNVTIPHKEEVVKFLDALSAEARAIGAVNTVLVERNLMVGYNTDAHAVYKLAGGHMEGAEVLILGAGGAARAALFAAIKAGAKKIYVKNRTAERAEALAREFREKFERPIEAIPWSGAVKADVVINATPIHDAVIADLTGASLYVEFVYTPTPRTKMVEEAERLGVKVVDGVDLLVEQGAQAEKIWLGVEPDRAVMKKAVLEFLGL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: THIE_METM5
Sequence: MKFKDKLKFYVITDSNYSDEVSSVEKALKGGASSIQLRMKTSSTRKMIEVGNKLRTLTSEYDALFFVNDRLDVAQAVNADGIHVGIDDMPVSKIKEIAPNLIIGASAYNIDEMKTAEYEGADYLGVGAVYSTNTKLDARNLGLDGLKDISKIANLPIVAIGGINHSNVENVLECGVSGVAVVSAIVGAENILKSAENMHELIKKYIK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: TM248_MOUSE
Sequence: MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTVGQARSSTQPPQSLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNADDCALHGHCEQAVFTACMTLTAAPGVFPVTVQPPHCIPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVVVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA
What are the official names of this protein?
Transmembrane protein 248.
What is the protein family that this protein belongs to?
Belongs to the TMEM248 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RIZA_BACIU
Sequence: MLRILLINSDKPEPIQFFQKDKETNDSINISVITRSCYAPLYSHWADHVYIVDDVTDLTVMKSLMLEILKVGPFDHIVSTTEKSILTGGFLRSYFGIAGPGFETALYMTNKLAMKTKLKMEGIPVADFLCVSQVEDIPAAGEKLGWPIIVKPALGSGALNTFIIHSLDHYEDLYSTSGGLGELKKNNSLMIAEKCIEMEEFHCDTLYADGEILFVSISKYTVPLLKGMAKIQGSFILSQNDPVYAEILELQKSVAQAFRITDGPGHLEIYRTHSGELIVGEIAMRIGGGGISRMIEKKFNISLWESSLNISVYRDPNLTVNPIEGTVGYFSLPCRNGTIKEFTPIEEWEKLAGILEVELLYQEGDVVDEKQSSSFDLARLYFCLENENEVQHLLALVKQTYYLHLTEDHMMNQ
What is the function of this protein?
Catalyzes the synthesis of Arg-Xaa dipeptides in an ATP-dependent manner.  Has strict specificity toward arginine as the N-terminal substrate.
What are the official names of this protein?
L-arginine-specific L-amino acid ligase, L-amino acid ligase RizA.
Protein: GSA_LEPIC
Sequence: MNQNKPTSKLISDFWKGKTSEELFERAKKVSPGGVHSPVRSFRSVGGTPVFFASAKGATLTDISGKEYIDYCLSFGPLILGHRDPEIEEVVRETTEIAWSFGAAEPYSLELAELISSRVPWAEKVRFVNSGTEAVMSALRVARAATGREKILKFDGCYHGHLDSLLVKAGSGLAGESSSDSAGISATSIANTLVLPLDDEASVERVFETEGKNIAALIIEPLPANYGLLIQRKEFLLKIVETARKYGTLVVFDEVISGFRVGFQGMSGLLGIWPDLVTYGKIIGGGFPVGCYAGKKDLLDLVAPSGPVYQAGTLSANPFGMRAGLATLKKAQRDSIYSVLDDRTKIFTDTMTKLLNKKSNQEWEAVIHSSLFWFRKKTQQPIRRIDLIPEGHKESFAKVFHTFLKNGIYLAPSGYEVGFLSWAHDDEIIAKTLEIADKALKTF
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y538_YERPY
Sequence: MSQRDTGAHYENLARRHLERAGLVFQAANVAFRGGEIDLIMRDGDAWVFVEVRFRRNDLFGGAAASITPRKQQRLHLAAAVWLAQRGASFATTSCRFDVVAITGNQLEWLPNAFNTD
What are the official names of this protein?
UPF0102 protein YPK_0538.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RECF_EDWI9
Sequence: MALTRLVIRDFRNIEEADLALAPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQAGRVIRHDCSAFVLHGRIDDGGGRERAVGLSKDRQGDSKVRIDGSDGHKVAELAQMLPMQLITPEGFTLLNGGPKYRRAFLDWGCFHGERSFFTAWNNLRRVLKQRNAALRQVTRYAQIRPWDQELVPLAEQVSALRAAYSEAIAQDIAATCSQFLPEYALSFSFMRGWDRESDYAALLERHFERDRALTYTAQGPHKADFRIRADGTPVEDLLSRGQLKLLMCALRLAQGEYLTRHSGRQCLYLIDDFASELDAGRRRLLAERLKSTGAQVFVSAVNADQIGDMVDEKGKMFHVEQGKIAV
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYPD6_HUMAN
Sequence: MEPGPALAWLLLLSLLADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIVSCLWLWLGLML
What is the function of this protein?
Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692).  Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019).  In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692).  Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
What are the official names of this protein?
Ly6/PLAUR domain-containing protein 6.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor. Synapse, synaptosome. Membrane raft.
Protein: RL19_MYXXD
Sequence: MRNAAIQHIEAKFLRQDVTVFNTGDSVRVHWKVKEGEKERVQAFEGIVIRKTKGNHRATFTVRKLSFGVGVERVFPLHSPRYEKIEVLSRGDVNRKRLFYLRALKGKAARVDVIEEPKPSKKAASAS
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MSRB_DEIRA
Sequence: MTQDTKTDFQKPSDNDLRERLTPIQYQVTQHEGTERAFTGEYWDHDEDGIYVDVVSGEPLFSSLDKYDAGCGWPSFTQPIPDVALTENTDYKIGYARTEVRSASADSHLGHVFPDGPRDRGGLRYCINSAALRFVPLSELDAQGYGQYRALFEGRQG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: Y3385_MYCPA
Sequence: MARTDDDTWDLATSVGATATMVAAGRARATRDGLIDDPFAEPLVRAVGVDFFTRWAAGELDAADVDVPGAAWGMQRMTDMLTARTRYIDAFFAEAGAAGIRQVVILASGLDARAYRLPWPAGTTVFEIDQPRVLEFKAATIAQLGAEPTAPVRAVAVDLRHDWPSALRQAGFDVGRPAAWAAEGLLGFLPPQAQDRLLDNVTALSADGSQLVAEVFANTGASGDALNAAGEKWRRHGLDVALDDLGFPGERNDPASYLQQLGWQPVRTPLNQMLANNGLPLQSTEPGAPFAQNYYCTAVLNKAG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_3385.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: TCO2_MOUSE
Sequence: MELLKALLLLSGVFGALAEFCVIPRIDSQLVEKLGQRLLPWMDRLSSEQLNPSVFVGLRLSSMQAGTKEDLYLHSLKIHYQQCLLRSTSSDDNSSCQPKLSGGSLALYLLALRANCEFFGSRKGDRLISQLKWFLEDEKKAIGHNHEGHPNTNYYQYGLSILALCVHQKRLHDSVVGKLLYAVEHDYFTYQGHVSVDTEAMAGLALTCLERFNFNSDLRPRITMAIETVREKILKSQAPEGYFGNIYSTPLALQMLMTSPASGVGLGTACIKAGTSLLLSLQDGAFQNPLMISQLLPILNHKTYLDLIFPDCQASRVMLVPAVEDPVHISEVISVTLKVASALSPYEQTFFVFAGSSLEDVLKLAQDGGGFTYGTQASLSGPYLTSVLGKDAGDREYWQLLRAPDTPLLQGIADYKPQDGETIELRLVRW
What is the function of this protein?
Primary vitamin B12-binding and transport protein.  Delivers cobalamin to cells.
What are the official names of this protein?
Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic cobalamin transport proteins family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y089_MYCTU
Sequence: MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRIPYVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTRTALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWPPPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV
What are the official names of this protein?
Uncharacterized methyltransferase Rv0089.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: SIT1_ASPFU
Sequence: MAMHDPHEKNGPDAVESRVQTDFPVERFGGNGSPGVRRIEVISSQFNLVHRIIFFFGVFLIAYVYGLDGTIRYTYQPLATAEYQSHSLLATVNVLRSVIAAAAQPTAAKIADVFGRVELILLSIVFYTVGTIVEASANHLYEFCAGAVLYQIGYTSVILLVEVLIADVTSTRSRLLFSYIPALPFLINTWISGNVTSAVLKVTSWQWGIGMFAIIYPVCTIPLLAVLFVGHLKARRANPQAYKFSLLDQGVGQFFIDLFWYLDVVGILLLIAILALILVPFTIAGGAVTQWKTAKVIAPLVIGVLCVPAFIVWERWCPHPMVPFKLLKDRAIWGALGIAVMLNTAWTLQGDYLYTVLIVSFDESVMSATRITSLYSFVSVITGTILGAIVIYVRRLKPFIVAGTLVFMAAFGILIRFRGGADGTNHAGIIGGQILLGFAGGLFPYPAQASVQVASKHKYLAVITGIYLATYNVGSALGNTISGAIWTQVLPGELENRLGNATLAAEVYANPFAFTQVNPVGTPDRDAVILAYKHAQRLLCITGICLTVPLIAFSLCIRNPRLTKEQTLKEAEEIDDK
What is the function of this protein?
Major facilitator transporter involved in ferrichrome (FC) and ferrioxamine B (FOB) uptake (PubMed:26929401).
What are the official names of this protein?
Siderophore iron transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCUS_ECOL6
Sequence: MRHSLPYRMLRKRPMKLSTTVILMVSAVLFSVLLVVHLIYFSQISDMTRDGLANKALAVARTLADSPEIRQGLQKKPQESGIQAIAEAVRKRNDLLFIVVTDMHSLRYSHPEAQRIGQPFKGDDILKALNGEENVAINRGFLAQALRVFTPIYDENHKQIGVVAIGLELSRVTQQINDSRWSIIWSVLFGMLVGLIGTCILVNVLKKILFGLEPYEISTLFEQRQAMLQSIKEGVVAVDDRGEVTLINDAAQELLNYRKSQDDEKLSTLSHSWSQVVDVSEVLRDGTPRRDEEITIKDRLLLINTVPVRSNGVIIGAISTFRDKTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATDLGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR
What is the function of this protein?
Member of the two-component regulatory system DcuR/DcuS.  Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; sdhCDAB; etc. ).  Weakly regulates the aerobic C4-dicarboxylate transporter dctA.  Activates DcuR by phosphorylation.
What are the official names of this protein?
Sensor histidine kinase DcuS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIBB_BUCAP
Sequence: MNQTLLSEFGNPIERVKKAISALQLGEGIIILDDEKRENEGDLVFSSETMTVEQMALTIRYGSGIVCLCITESKRKKLNLPMMVKHNTSTYRTGFTVTIEASKGVSTGVSAKDRLTTIKTATADDAQPSDLNRPGHVFPLRANGGGILARAGHTEAAIEIVSLAGFKPYGVICELTNKDGSMSRTPEIIKFSKSKKMKILTIKDLILYVQNKK
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: UPAR_MACFA
Sequence: MGHPLLLPLLLLLHTCVPASWGLRCMQCKSNGDCRVEECALGQDLCRTTIVRMWEEGEELELVEKSCTHSEKTNRTMSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTFSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPSCPGSSGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGHQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTYEPKNQSYMVRGCVTASMCQRAHLGDAFSMHHINVSCCTESGCNHPDLDIQYRKGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
What is the function of this protein?
Acts as a receptor for urokinase plasminogen activator.  Plays a role in localizing and promoting plasmin formation.  Mediates the proteolysis-independent signal transduction activation effects of U-PA.  It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity).
What are the official names of this protein?
Urokinase plasminogen activator surface receptor, U-PAR, uPAR.
What are the subcellular locations of this protein?
Cell membrane. Cell projection, invadopodium membrane. Cell membrane; Lipid-anchor, GPI-anchor. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Protein: SCPA_STREM
Sequence: MDIKVKDFEGPLDLLLHLVSKYEVDVYQVPIVDVIEQYLAYIETLQAMRLELAGEYMLMASQLMLIKSRRLLPKLVDKEPDEEDLEQELLGKIEEYSRFKALSQELASQHDKRALLFSKPKQELIFEQAVLQKDKTVMDLFLAFSQLMAAKQEAFKYNHTVIERDDYRIEDMMELIEARLELEQELTLTDLLKHCDHLNEAITLFLASLELIKRQLVGIEQTSHFGQIVLRKEIQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: RL6_LACAC
Sequence: MSRIGLKTIEVPDSVTVTKEGDNITVKGPKGELTRYFDPKITFEQNDGEINFSRSSESDKALHGTERANLASMIEGVLNGYKKTLKLIGVGYRAQAQGNKITLNVGYSHPVVLTAPEGVSVKATSATDVEVEGVSKQDVGQFAAEIRAVRPPEPYKGKGIRYVDEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SGTA_RAT
Sequence: MDNRKRLAYAIIQFLHGQLRHGGLSSDAQESLEVAIQCLETAFGVTLEDSDLALPQTLPEIFEAATASKEMPQDPRGPDRTPPSEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGSLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQHSDLASLIQAGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE
What is the function of this protein?
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol.  Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails.  Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module.  Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins.  It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.  Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (By similarity).  Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:12878599).
What are the official names of this protein?
Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Small glutamine-rich protein with tetratricopeptide repeats 1.
What is the protein family that this protein belongs to?
Belongs to the SGT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.