Protein: FGM5_GIBZE
Sequence: MAVSGCTNDNSFGPIVQGCRGDFDFTLRFQNIILGILPAAIFILLALTRVATLAFRSRIVGGKVLQFTKLAVIAATAALQLVLLILSSTSNDESVDGDTFAVANSALGFSQWIVTLALSFAEHSRAPRPSSILTLYLLLQILLDVTRCRSYWLLATSFQITRYAGVFTATIGLKVITLLLELQNKARWMTWRKEDHSPEETSSLFNLGVYFWLIGIFRNGFKKTLSIKDDLYLLDHEMQSKILLDRLTISFAKSSANVGKRFRLAKALGRALIVPLILPVVPRIAMIGFQYAQPFFIHALLEYLIHKDVPKNDGYGLIGAALIIYAGIAISDALFWYFHQRCLYMARGCLASYVYRSTTQGKMTDIGDAAVLTLMSTDVERIIYGFHGLHDFWANIIEIGLGCFLLQRQLGLAFISPIVVILLCVAATTAIAWAIGERQSRWMAKIESRVGLTSSIISNIKSLRISGITAPVRDLVQKMREQELSIGNKFRWLLIMTATVAFVPSAMSPVVAFAFTNEQLDTLKIFVSFSFITLLTNPLGAMFQSVPAVIAAFVCLERIQKFLEIEPRVDYRKSSRPLSPADGSLLEQDDEKPLGLGQGASKSLISIVDGSFGWTSEKMTLTGISVDVPVGKLTLVVGPVASGKSTFCKALLGEVPFSSGEVIVPSTEAPIGYCEQTPFLKNGSIRDNIIWHSVYNQTRYEEVLDACLLRTDLDILPEGDATTIGSNGIMLSGGQKQRVSLARALYLETDFLLIDDILSGLDNSTGNDVFRRVFGPNGLMRRRNATAILCTHAIRYLPLADHIIILATDGTVGEQGSFDKLAETGIYIPTLGLSDADDASSTNSSIPVEETVAATMPVPLTAFSTVSIGHLEAESRSTGDAKVYRHYYQSVNGWATMTCLLSGIMYAVGRNFPSIWMGWWGSNSFDRTSSFYIGIMGLFRGLQIISLFLCATAVVIFMTTQSGKLLHNEILNTLVNAPLRFFTTTDFGAVTNLFSQDMTLIDGELPISLLNTVIQIFDVFAMAVVVAVGAPWLAIAYPVVFSIIYMLQMFYLRTSRQLRLLDLEAKSPLYAHFLDTIRGIATVRAQKLRDQEILFNQDLLNLSQRPAYLLAMAQRFLATFLNLIVMVLAVGVVAISTQLRTNSGFAGSSLVTLMSWGESISSLIQYYTQVEVSIGAVSRLKAFAQNVPSENLDQEDLEPAEEWPTQGDIAIRGVSASYKNDDESPASEDDEESPNLALEDLTILVKPGQKVALCGRTGSGKSSIILLLLRLLDPLSNQSENIVIDGVPYNRVNRSILRRRLIAVPQDPVFLPDGSSIKENLDPFNVASDEECLAVLEDVRLTKFATDHGSIHAGIRADELSAGQKQLFSLGRAVLRRRVKQRLFSIHGGVLLLDEVSSSVDSATDNLVQEIIKEEFADYTIVMVSHRLNIVMEYFDSVVVLDRGRVVETGDPRDLAKTEGSWFSQLWAMEKK
What is the function of this protein?
ABC transporter; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501).  The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892).  During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892).  The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892).  Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892).  The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
What are the official names of this protein?
ABC transporter FGM5, C64 cluster protein NRPS5, Fg3_54 cluster protein FGM5, Fusaoctaxin A biosynthesis cluster protein FGM5.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.