PharMolix/UniProtQA huggingface dataset:
Protein: GPMB_ECO55
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVATRAKELGITHIISSDLGRTRRTAEIIAQACGCDIIFDSRLRELNMGVLEKRHIDSLTEEEENWRRQLVNGTVDGRIPEGESMQELSDRVNAALESCRDLPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRVDYQESLWLASGWVVETAGDISHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: MZRA_MUSP7
Sequence: MINRRMKTGFVFHLLLLLLPLVVLVTSSRRTADDVTLHIIPQHQGAALPDGFYIYQRLNEHGIGIKSITPEDDSIIVRLSSPEQSRAASEVLKSALPQASVIARQPDAIPIWRQKLSQQPFKLG
What is the function of this protein?
Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.
What are the official names of this protein?
Modulator protein MzrA.
What is the protein family that this protein belongs to?
Belongs to the MzrA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RLMN_PROMM
Sequence: MSSTHLPGGNQALLGCSATELEGWAVAEGQPAFRGRQLHEWLYAKGARSFEAITVLPKSWRLSLQQRGITIGRLLEVNRAVAVDDTTKLLLATVDGETIESVGIPTQQRLTVCLSSQVGCPMACRFCASGKGGLQRSLATHEIVDQVLSLREAMDRRPSHVVFMGMGEPLLNIEAVLAAIRCLNIDLGIAQRRITVSTVGVPHTLPHLAELAMKRLGRAQFTLAVSLHAPNQELRERLIPTACAYPFETLLQDCRHYLAVTGRRVTFEYILLGALNDQPQHAEELADRVRGFQSHVNLIAYNPIDDEGFQRPNPETIEAFRRVLEQRGVAVSLRASRGLDQNAACGQLRRQHAATG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMO1B_XENLA
Sequence: MSDQEAKPSSEDLGDKKEGGDYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRISDHQTPKELGMEEEDVIEVYQEQTGGHSTI
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (By similarity).  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 1-B, SUMO-1-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus.
Protein: MBLC1_BOVIN
Sequence: MSGLVRTEPLPGETPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQAWGPASSHREPQPYEAKTALEEAARGPILVDTAGPWAREALLGALAGQGVAPGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEERPLRLGPGLEVWATPGHGGQRDVSVLVAGTALGTVMVVGDVFERDGDEGSWQALSEDPVAQKHSRKRILGTADVVVPGHGAPFRVIREASAPETEPARSRDGEEPTVHG
What is the function of this protein?
Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end.  Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase.  Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop.  May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.
What are the official names of this protein?
Metallo-beta-lactamase domain-containing protein 1, Endoribonuclease MBLAC1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Localizes in the nucleus during early S-phase of the cell cycle.
Protein: DEF_STRPQ
Sequence: MSAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDILLGEKMMQFLKHSQDPVMAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPKEAYSWQEVLYNPKIVSHSVQDAALSDGEGCLSVDRVVEGYVVRHARVTVDYYDKEGQQHRIKLKGYNAIVVQHEIDHINGVLFYDRINAKNPFETKEELLILD
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ISPH_PROMT
Sequence: MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLAEAFGFCWGVERSVAMAYETRKHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKDFSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWVSKVWHTVEKHKKHTFTSIIHGKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKDLQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFSLVDEPLDLMVVIGGFNSSNTTHLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGELLTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGENF
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: TRUD_PYRNV
Sequence: MIEAPPFDRSLGMLYYATDTYPSGGVIKAKPEDFLVEEVLYDGTVVALEGVSIEPRVGGWTWIHVVKRNVDTVKLVLRLAKALGLRSRDISIGGIKDTRAVTSQIVSVRGNVADLPKIPNVQFLGLWPMDKPIAPSLIYGNRFTIVLRNVERRECAEAALAALGKAALPNYYGYQRFGTIRPVSHLLGKALLRKDAEGFFHVMFCKIFPYESEAAKKARELACRGEYQKALEAFPRGFVEERALLRRLVRGSDLWNAAMAIPLQILRIYIEAAQSHLFNLLLSKRMELGPLDRPVEGDLVEVNGQVTYYVEDLGGEVVVPVVGAGVRMPRGRVLEAFVKVLKEEGLEPSAFLQMPRGLRAYGSYRRARLQARDLAYSLGDDLVLRFVLPRGGYATVLLREVVKPTEPYRHGF
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HCDH_RAT
Sequence: MAFVTRQFVRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
What is the function of this protein?
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity).  Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).
What are the official names of this protein?
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PROT_VITXG
Sequence: MSDDDKRHMELARLLVSLFPGRKLNGFLVGLLHSLSGRYRLPKELRGDRVPSSSKLARFIGTLDRERHIHSYFWDLLRRERPSRVGDIDRVARLWEEEGHWKGLESLRFPAGEVFPQVARGSSDNNGAPPLSFTLSHGDPKSDPEPSSPSRLVNTGLSEAERPESPLASDQCLVTSHAYFFWLEVGAWIEGSIEDEPVSLPEDLPSGARLRVVLFSSPGGLVLQPDADQGVLCIEGDGRVVVERPACVPPALQSRELADRRLFFPLRTPQAPGTYRLRCNIHHEGLLVQSRDVVLTVAEQPQRQSEALRSRVDYALSQTLSPTHLRQLGSATLSVLLNDDDWGTHGFRFVGGDDYRSSVHLDDAMLQEMISLARGAFRRASWGSKERYEALPSRPPYRYQGAQSEARLREDLVMMARIGRQLYDRVAEQLGQGADGADALRERMRLPGHIQLALKQGARHLVPISIFYDHRLDVALKDFTLCEAFIRASVASEPLEKSPCFQGDCPHREDRDVVCPSGFWGFRHTLALPFGMAAQGERGLMDLPGVLRIRDTPALLIAVSEDPDFVLRDNHLMRLQAMSGVAPIQVARSREKALELLRQQGSHLVYFYCHGGVDAETRAPFLQVGPLTDPYIFRDTLRVYDIRWRDPAPHPLVFINGCHTTELEPEQAIELVSGFVERAGAAGVIGTEVTIFEPLAVGFASRFMDAFLRRRLSLGASVREARLGILQHDFNPLGLVYLPFALSSLHLAGEASEGTSVAGGAGALVTPPA
What is the function of this protein?
Probably a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death.  Involved in defense against bacteriophages (Probable).  Expression of gasdermin bGSDM and this neighboring protease is toxic in E. coli (PubMed:35025633).
What are the official names of this protein?
Probable protease Ga0334635_1659.
Protein: RSMH_SYNJB
Sequence: MQILNFVAAEIEPPQTVLGKVYQHDSVLTEEVMAYLQPQGGGIFLDVTLGGGGHSLALLRGGAARVVGLDRDPAALQAAQARFAAEGIPGSRIQLWHLNFADFDLQQHGFRDEQGQGIPFDGIVADLGVSSPQLDCPERGFSFRGEGPLDMRMDPSAAQETAADWVNHRPVEELIEIFTRYGEERFARRIAHHIEQARPLATTTQLAQVVWQAVPPAARRGRIHPATRVFQALRIAVNRELEALETLLAQAPTWLKPGGRLAVISFHSLEDRLVKWAFRRDPRWQVLTPKPLSPSELERQRNPRARSAKLRVAARSSQM
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_CHLL3
Sequence: MEWSESVFDGRRREMVEGLRRSGIMNARVLEAFLEVRRHLFFPESEREHAYDDAAWPIGHGQTISQPYTVAYMTSLLADRVPSGKVLEVGTGSGYQSAILDAMGYRVFTIERVAALYSEALGRFRRFALPVAAKLGDGSEGWPEEAPFNAVLVTAAAPKEPEALLRQLSDNGCLVIPLGGMDVQQMTVITRRGEVFLKERYHEFAFVPLIGREGWEEEQEQS
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_LACRH
Sequence: MANDQNKDYDKIIVLDYGSQYNQLITRRIREFGIYSELKPHTITAAEVKKIAPKGIIFSGGPNSVYDEGALGVDEDIFKLGIPILGVCYGMQLMAQRLGGDVEPADNREYGKADIEVTDASAKLFHDLPKDQTVWMSHGDLVTRVPDGFRTTATSVNCPISAMDDDDRKFYGIQFHAEVQNTQYGHEILHHFAFDVCHAEANWSMDDFITKQIAKIRAEVGDKRVLLGLSGGVDSSVVGVLLHKAIGTQLTSIFVDHGLLRKGEAEQVMDSLKGKFGLNIIKVNAKDRFLNDLRGVTDPEKKRKIIGRDFIEVFNEEAAKLNGIEFLAQGTLYTDVVESGTDTAQTIKSHHNVGGLPEDLKFKLIEPLNKLFKDEVRELGEKLGMPHSLVWRQPFPGPGLGIRVIGEVTEDKLEIVRDSDYILREEIAKHGLDKDIWQYFTVLPGIRSVGVMGDGRTYDYTIGIRAITSIDGMTADFARIDWDVLQEISSRIVNEVKHVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: LRAT1_HUMAN
Sequence: MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDDEEDLDERGQPDKFGVKAPPGCTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE
What is the function of this protein?
May play a role in cell morphology and motility.
What are the official names of this protein?
Protein LRATD1, LRAT domain-containing 1, Neurologic sensory protein 1, NSE1, Protein FAM84A.
What is the protein family that this protein belongs to?
Belongs to the LRATD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_SHESW
Sequence: MWLGVITLFPEMFRAVTDFGVTGRAVKNGLLELHTWNPRDFTHDRHNTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEEAKVIYLSPQGRKLDQQGVTELAKSSRLILVCGRYEGIDERIIQTEVDEEWSVGDYVLSGGELPAMTMIDAVSRLVPGVLGKQASAEQDSFSDGLLDCPHYTRPESLDGLDVPAVLLSGNHEQIRLWRLQQSLGRTLLRRPELLQNLALTDEQSTLLAQFVEAMDKHA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YI001_HUMAN
Sequence: MRRERPELRDAEGRLRLRAGCLVTAWPRAPSGAGSWSMAAASPWPASWGFPDASSTVPSLCTEARAGRGGPATARSRVSADSQGGRAGSSSPSSALRLCCAGPSQAHPGPSPAVLPGRCGLLGSFPRPPAPQGRWGPSLG
What are the official names of this protein?
Uncharacterized protein FLJ30774.
Protein: RL36_ELUMP
Sequence: MKVRASVKKICQKCKVIKRNGVLRVVCDVKKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RS14Z_CLOBM
Sequence: MARKALIEKWNKTPKHSTRAYTRCRICGRPHAVLKKYGICRICFRELAYKGEIPGCKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RUVC_SALHS
Sequence: MSIILGIDPGSRITGYGVIRQVGRQLTYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HPRK_BACC0
Sequence: MPKVRTKDLIEQFHLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue.  Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: Y1014_TREPA
Sequence: MVCSITLLKVRSKRHLLSYLGVVGVGIAGLCIYRSVWGSRPFLERLARADSLIAQERKGAALRGLARMVGHARESSQYLSIAKRQMELSASAAALRTLQRGIRRSADDGRLAALVIHLLLREARFEEAISYVPRVVHKGYESIGAEALIKAALIGSRTGGDSPSRGSFHSERAEHVPEEPVEFSQVQGGRDQAHVTAFPLDRGEEQFRVEPSPPIRHTTGIALARIAPALWLAAFGVTGMHAFLQNAACAYARVGELHAAFRLYSRILGTEAPENTAFWATVAYDAGQFSLVFELLPISLARADLFGTYSAASTHARTHLLLAADAAFDGGDRARARAFWYAYVDRFPGTSTHALYNLALTAPHAQERVRMLAQCVEGDKTYYPAVACYARESIAFRAAHRQRDSVTELLSERGVYSVQMEQEHFLSPHFPVEARSLLAELAQEAMHGRADVRFALEYFRFCYPAQKRLQGSRGALWQLLEVFPVDTQVRRYARWFFFRIGEYESAFGLSDAGGGPEDAFYRALAAASRTGRVESILGGLVEATRAVEARSAAFANIAIVLERMGKKTAAAEHFVLAADEATRESVRQLQKEAGEGEAEEHPRARPAAGKAQRWREWYQRAGQLLQQQGKTVAARALLQRAQAR
What are the official names of this protein?
Uncharacterized protein TP_1014.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RPC7L_BOVIN
Sequence: MASRGGGRGCGRGQLTFNVEAVGIGKGDALPPPTLQPSPLFPPLEFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAVPKRDVERYSDKYQMSGPIDNAIDWNPDWRRLPRELKIRVRKLQKERTTIILPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEEKEEEEEEEYDEEEHEEETDYIMSYFDNGEDFGGDSDDNMDEAIY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC7-like, RNA polymerase III subunit C7-like, DNA-directed RNA polymerase III subunit G-like.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMI_SALA4
Sequence: MTESTFPQYPRLVLSKGREKSLLRRHPWVFSGAVSRLEGKANLGETIDIVDHQGKWLARGAWSPASQIRARVWTFDKAESIDIAFFTRRLRQAQQWRDWLAKKDGLDSYRLIAGESDGLPGVTIDRFGHFLVLQLLSAGAEYQRAALISALQTCYPDCAIYDRSDVAVRKKEGMALTQGPVTGELPPALLPIEEHGMKLLVDIQGGHKTGYYLDQRDSRLATRRYVENQRVLNCFSYTGGFAVSALMGGCRQVVSVDTSQDALDIARQNVELNQLDLSKAEFVRDDVFKLLRAYREHGEKFDVIIMDPPKFVENKSQLMGACRGYKDINMLAIQLLNPGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP22_VZVO
Sequence: MASSDGDRLCRSNAVRRKTTPSYSGQYRTARRSVVVGPPDDSDDSLGYITTVGADSPSPVYADLYFEHKNTTPRVHQPNDSSGSEDDFEDIDEVVAAFREARLRHELVEDAVYENPLSVEKPSRSFTKNAAVKPKLEDSPKRAPPGAGAIASGRPISFSTAPKTATSSWCGPTPSYNKRVFCEAVRRVAAMQAQKAAEAAWNSNPPRNNAELDRLLTGAVIRITVHEGLNLIQAANEADLGEGASVSKRGHNRKTGDLQGGMGNEPMYAQVRKPKSRTDTQTTGRITNRSRARSASRTDARK
What is the function of this protein?
Tegument protein that plays different roles during the time course of infection (By similarity).  Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (By similarity).  Modulates the RNase activity of the virion host shutoff protein ORF17 probably to ensure necessary levels of key cellular mRNAs and proteins (By similarity).  Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (By similarity).  Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA (PubMed:34015248).  Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (PubMed:34015248).
What are the official names of this protein?
Tegument protein VP22, Tegument protein 9.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae VP22 tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs.
Protein: DPP4_ASPFU
Sequence: MKWSILLLVGCAAAIDVPRQPYAPTGSGKKRLTFNETVVKRAISPSAISVEWISTSEDGDYVYQDQDGSLKIQSIVTNHTQTLVPADKVPEDAYSYWIHPNLSSVLWATNYTKQYRHSYFADYFIQDVQSMKLRPLAPDQSGDIQYAQWTPTGDAIAFVRDNNVFVWTNASTSQITNDGGPDLFNGVPDWIYEEEILGDRFALWFSPDGAYLAFLRFNETGVPTFTVPYYMDNEEIAPPYPRELELRYPKVSQTNPTVELNLLELRTGERTPVPIDAFDAKELIIGEVAWLTGKHDVVAVKAFNRVQDRQKVVAVDVASLRSKTISERDGTDGWLDNLLSMAYIGPIGESKEEYYIDISDQSGWAHLWLFPVAGGEPIALTKGEWEVTNILSIDKPRQLVYFLSTKHHSTERHLYSVSWKTKEITPLVDDTVPAVWSASFSSQGGYYILSYRGPDVPYQDLYAINSTAPLRTITSNAAVLNALKEYTLPNITYFELALPSGETLNVMQRLPVKFSPKKKYPVLFTPYGGPGAQEVSKAWQALDFKAYIASDPELEYITWTVDNRGTGYKGRAFRCQVASRLGELEAADQVFAAQQAAKLPYVDAQHIAIWGWSYGGYLTGKVIETDSGAFSLGVQTAPVSDWRFYDSMYTERYMKTLESNAAGYNASAIRKVAGYKNVRGGVLIQHGTGDDNVHFQNAAALVDTLVGAGVTPEKLQVQWFTDSDHGIRYHGGNVFLYRQLSKRLYEEKKRKEKGEAHQWSKKSVL
What is the function of this protein?
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.  Contributes to pathogenicity (By similarity).
What are the official names of this protein?
Probable dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, DppIV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURA2_METAC
Sequence: MFTIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGNNAGHTVRVGDEVYKLHLIPSGILLDARVLIGPGVVLNPEVLAEETAMFEKHGIKVDAEKLGVDAKTSIIMPYHIEMDGLREAARKTKIGTTKRGIGYAYIDKVARDEIRMAELVDKERFLKRLEELAPQKEKEIEAMGGDPKIVRDPFLIQKYLELGEQFASYVTDVSREINQALDEGKHVMAEAAQGTHLDVIHGTQKFVTSSSTIAGSACANLGVGPTRVGNVIAIVKAYITRVGEGPLPTELSGELGEKIQKAGGEFGTTTGRGRRCGWFDLPLLKKAIALNGYTEISLTKLDVLTGLEPLRICVGYKYKGEDLDYPPELTEDLWECSPVYEDLPGWETDLTEVKAYSELPENAQNYIKRLEELMKVPINYISVGPGREQTFKKE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase 2, AMPSase 2, AdSS 2, IMP--aspartate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.