PharMolix/UniProtQA huggingface dataset:
Protein: RL15_GEOSL
Sequence: MELNELRPAVGATKDRKRIGRGPGSGHGKTATKGHKGQKARSGGSVKPGFEGGQMPMQRRLPKRGFTPLTRKEYALVNVGQLEVFEAGSCIDVEALLNAGLIGGVKDGLKVLADGDLTKPLTVKAHKFSAKAKEKIAAAGGTVEEISL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: O16A_CONCL
Sequence: MKLTCVLIAAVLLLAVCQLDSADATAYMRKDPSLRSPKRTRGCKTKGTWCWASRECCLKDCLFVCVY
What are the official names of this protein?
Conotoxin Cl6.10.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: 3MGH_PARPJ
Sequence: MRKHQLPILPLLRDDLPLDTVELARFMIGKYLVHDLPEGRMSGRIVETEAYPLGDSTSHAFMGRRPHNGSMFLAPGHAYVRLTYGLSYMLNMSAEAEEVGAGILLRAIEPLEGLPLIEARRPGVPLRDLARGPGRLTMAFGVGPSFDGWDLCSGQGLWIGVIERGEVPVGVTTRIGLSREMHQPLRFFEPGSAFVSGPRKLLVTPQSGAPKRA
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: CAT2_ECOLX
Sequence: MNFTRIDLNTWNRREHFALYRQQIKCGFSLTTKLDITALRTALAETGYKFYPLMIYLISRAVNQFPEFRMALKDNELIYWDQSDPVFTVFHKETETFSALSCRYFPDLSEFMAGYNAVTAEYQHDTRLFPQGNLPENHLNISSLPWVSFDGFNLNITGNDDYFAPVFTMAKFQQEGDRVLLPVSVQVHHAVCDGFHAARFINTLQLMCDNILK
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase 2, Chloramphenicol acetyltransferase II, CAT-II.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.
Protein: CRFR2_HUMAN
Sequence: MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
What is the function of this protein?
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3.  Has high affinity for UCN.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase.  Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
What are the official names of this protein?
Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
Protein: XIAP_RAT
Sequence: MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKSENCVGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKTFQNWPDYAHLSPRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLGESVVRTAEKTPSVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTMEEKLQTSGSNYLSLEVLIADLVSAQKDNSQDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCCTVITFKQKIFMS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis.  Acts as a direct caspase inhibitor.  Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry.  Inactivates CASP9 by keeping it in a monomeric, inactive state.  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin.  Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation.  Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation.  Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation.  Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation.  Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation.  Acts as an important regulator of innate immune signaling via regulation of Nod-like receptors (NLRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.  Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES.  Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP homolog A, Inhibitor of apoptosis protein 3, IAP-3, rIAP-3, rIAP3, RING-type E3 ubiquitin transferase XIAP, X-linked inhibitor of apoptosis protein, X-linked IAP.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Protein: SYG_METTH
Sequence: MINVNHERTMTVARKRGFLWSSFEIYSGVAGFVDYGPLGATLKNKIMNRWREFYVVREGFYEIESPTIMPEEALKASGHVDHFNDPMTQCKECMDVYRADHIIEDATGRDVEGLENQELTEIISDEGIRCPRCGGHLTHVWSYNLMFQTLIGARGKKTGYLRPETAQGIFIPFKRLLRFFRNRLPFGVVQLGKSYRNEISPRQGVIRLREFTQAEAEIFVDPEHKTHPDFEEVKEDILRLYPAGRQMEESGTVDMTAAEALEAGVISSEVLTYHLCLAKRFLMDIGIPEDALRFRQHLPSEMAHYAIDCWDVEAFTDSYGWIEIIGIADRTDYDLRSHSQHSGEDLRVFIEYDEPRRIRKRAVKPDMGKLGPKFRKDAARIASALSEVDVEEIEKALDEEGRFILEGEFEILPDDVSFEDVEEVVTGRKVYPHVIEPSFGIDRIIYTLLLHSLVDDGERTYFRLPPHVAPVEVTVLPLVNREEMVMTALEIERNLRRSGFIAEFDSSGTIGRRYARADEIGVPFAVTVDHETLEDGTVTLRNRDDCSQVRVKIEELVPTLEKLRG
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_SALEP
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGQVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHIAMVGDLKYGRTVHSLTQALAKFSGNRFYFIAPDALAMPQYILDMLDEKGMAWSLHGSIEEVMADVDILYMTRVQKERLDPSEYANVKAQFVLRASDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSELSL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: FPPS2_PARAR
Sequence: MSTDIRSKFLQVYDTLKSELINDPAFEFDDDSRQWIEKMLDYNVPGGKLNRGLSVIDSYQLLKGGKLTDDEIFHASALGWCVEWLQAYFLVLDDIMDESHTRRGQPCWFRLPKVGMIAANDGIILRNHVPRILKKHFRGKPYYVDLVDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLSIHRRIVQYKTAYYSFYLPVACALLMFGEDLEKHVEVKNVLVEMGTYFQVQDDYLDCFGAPEVIGKIGTDIEDFKCSWLVVKALELANEEQKKVLHENYGKKDPSPVAKVKELYNTLNLQGVFEDYENTSYKKLITSIEGHPSKAVQAVLKSFLGKIYRRQK
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
What are the official names of this protein?
Farnesyl pyrophosphate synthase 2, FPP synthase 2, FPS 2, (2E,6E)-farnesyl diphosphate synthase 2, Dimethylallyltranstransferase 2, Farnesyl diphosphate synthase 2, Geranyltranstransferase 2.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Rubber particles.
Protein: ACCA_RHIEC
Sequence: MHNYLDFEKPISDLEGKIIELKKLASEDESIDTTDEIGRLEVRVREAIVEIYSKLNAWQKTQVARHPQRPHFVDYAKTLFQEFTPLAGDRKFSEDAAIQAGLARFRGQPVAVIGQEKGNDTKSRLKHNFGSPRPEGYRKAIRILEMADRFGLPVISLVDTAGAYPGVGAEERGQAEAIARSTEMCLGVKVPLVSVVIGEGGSGGAIAIATGNRVYMLEHSIYSVISPEGAASILWRDSTRAREAATNMKITAEDLKSLGVIDGIISEPLGGAHRDPDSVIAATGDVIANALGEMASRSGEQLRNERRQKFLNMGRNL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRODH_DEIRA
Sequence: MIDQLYRKAVLTVAERPQVEQLARQKMWNLAERFVAGESIESAIQAVQALERDGIAGNLDLLGEFIDSPAKCTEFADDVIKLIEAAHAAGIKPYVSIKLSSVGQGKDENGEDLGLTNARRIIAKAKEYGGFICLDMEDHTRVDVTLEQFRTLVGEFGAEHVGTVLQSYLYRSLGDRASLDDLRPNIRMVKGAYLEPATVAYPDKADVDQNYRRLVFQHLKAGNYTNVATHDERIIDDVKRFVLAHGIGKDAFEFQMLYGIRRDLQKQLAAEGYRVRVYLPYGRDWYAYFSRRIAETPRNAAFVVQGMLKG
What is the function of this protein?
Converts proline to delta-1-pyrroline-5-carboxylate.
What are the official names of this protein?
Proline dehydrogenase, PRODH, DrPRODH, Proline oxidase.
What is the protein family that this protein belongs to?
Belongs to the proline dehydrogenase family.
Protein: VDH_STRVG
Sequence: MTEADNGVLHTLFHSDQGGHEQVVLCQDRASGLKAVIAIHSTALGPALGGTRFYPYATEEEAVADVLNLSRGMSYKNAMAGLDHGGGKAVIIGDPEQIKSEDLLLAFGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTAFGVFQGMRASAEHLWGDPSLRGRKVGVAGVGKVGHHLVEHLLEDGADVVITDVREESVNRSTHKHPSVTAVADTEALIRTEGLDIYAPCALGGALDDDSVPVLTAKVVCGAANNQLAHPGVEKDLADRSILYAPDYVVNAGGVIQVADELRGFDFDRCKAKASKIFDTTLAIFARAKEDGIPPAAAADRIAEQRMSDAR
What is the function of this protein?
Oxidative deamination of branched-chain amino acids.  The catabolism of valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors.
What are the official names of this protein?
Valine dehydrogenase, ValDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: ASIP_CALJA
Sequence: MDVTRLLLATLLVFLCFFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAEKKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVLNVNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXB_ECOBW
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: SEPF2_STRAW
Sequence: MAGAMRKMAVYLGLVEDDGYDGRGFDPDDDFEPELDPEPERDRRRHEPPHQSHQALHPQRDESVRVVQPPMQRDPVPHSASLPAESVRPARIAPVASITQERQSLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF 2.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: NSP_SLCV
Sequence: MYSTSNRRGRSQTQRGSHVRRTGVKRSYGAARGDDRRRPNVVSKTQVEPRMTIQRVQENQFGPEFVLSQNSALSTFVTYPSYVKTVPNRTRTYIKLKRVRFKGTLKIERGQGDTIMDGPSSNIEGVFSMVIVVDRKPHVSQSGRLHTFDELFGARIHCHGNLSVVPALKDRYYIRHVTKRVVSLEKDTLLIDLHGTTQLSNKRYNCWASFSDLERDSCNGVYGNITKNALLVYYCWLSDAQSKASTYVSFELDYLG
What is the function of this protein?
Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus.  Begomoviruses use 2 proteins to transport their DNA from cell to cell.  The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall.
What are the official names of this protein?
Nuclear shuttle protein, NSP, Protein BR1, Protein BV1.
What is the protein family that this protein belongs to?
Belongs to the begomovirus nuclear shuttle protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocated to the plasma membrane by the movement protein BC1.
Protein: UNG_XYLFM
Sequence: MNEQGEAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIFAAFEATPFQRVKAVILGQDPYHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRPDHGCLLPWANRGVLLLNAVLTVEDGRAGAHQGKGWEGFTDHVVDTLNREREGLVFMLWGSYAQAKGKVIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCIALDGAILNGRIAV
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOTB_KLEP3
Sequence: MTTNTVSRKVAWLRVVTLAIAAFIFNTTEFAPVGLLSDIAGSFGMETAQVGMMLTIYAWVVALMSLPFMLLTSKMERRRLLIGLFILFIASHVLSFFAWSFDVLVISRIGIAFAHAVFWSITSALAIRMAPPGKRAQALSLIATGTALAMVFGIPIGRIIGQYFGWRMTFLAIGLGALATLACLVKLLPTLPSEHSGSLKSLPVLFRRPALVSVYILTVVVVTAHYTAYSYIEPFVQTVAGLSGNFATVLLLILGGAGIIGSILFGKLGNQHASGLISIAIGLLLACLLLLLPASDNAHHLMLLSIFWGVAIMIIGLGMQVKVLASAPDATDVAMSLFSGIFNIGIGAGALVGSQVSLHLSMASIGYIGAIPALAALVWSLMIFRRWPVSLEDHQPHHS
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CIAR_STRR6
Sequence: MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVYFLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ
What is the function of this protein?
Member of the two-component regulatory system CiaH/CiaR.  Involved in early steps of competence regulation and in penicillin susceptibility.
What are the official names of this protein?
Transcriptional regulatory protein CiaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AXS2_ARATH
Sequence: MANGADRLDLDGKPIKPMTICMIGAGGFIGSHLCEKLMTETPHKVLALDVYNDKIKHLLEPDTVQWAGRIQFHRINIKHDSRLEGLIKMADLTINLAAICTPADYNTRPLDTIYSNFIDALPVVKYCSENNKRLIHFSTCEVYGKTIGSFLPKDHPLRQDPEFYVLKEDISPCIFGSIEKQRWSYACAKQLIERLVYAEGAENGLEFTIVRPFNWIGPRMDFIPGIDGPSEGVPRVLACFSNNLLRREPLKLVDGGESQRTFIYIKDAIEAVLLMIENPERANGHIFNVGNPNNEVTVRQLAEMMTEVYAKVSGETAIESPTIDVSSKEFYGEGYDDSDKRIPDMTIINRQLGWNPKTSLWDLLESTLTYQHTTYAEAIKKATSKPVAS
What is the function of this protein?
Catalyzes the conversion of UDP-D-glucuronate to a mixture of UDP-D-apiose and UDP-D-xylose.  D-Apiose (3-C-hydroxymethyl-d-erythrose) is the only plant cell wall monosaccharide with a branched carbon skeleton and is found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides (By similarity).
What are the official names of this protein?
UDP-D-apiose/UDP-D-xylose synthase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GORS2_MOUSE
Sequence: MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMTGTPITPLKDGFTEVQLSSVSPPSLSPPGTTGVEQSLSGLSISSAPPAVSNVLSTGVPTVPLLPPQVNQSLASMPPMNPATTLPSLMPLSAGLPSLPNLPSLSNFNLPAPHIMPGVGLPELGSPGLPPLPSLPPRNLPGIAPLPMLSDFLPSFPLVPEGSSAASAGEPLSSLPAMGPPSDPVMTTAKADASSLTVDVTSPASKVPTTVEDRVSDCTPAVEKPVSDADASEPS
What is the function of this protein?
Key structural protein of the Golgi apparatus (PubMed:32573693).  The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693).  Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693).  However, other studies suggest that GORASP2 plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (By similarity).  May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity).  Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (PubMed:28617811).  Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity).
What are the official names of this protein?
Golgi reassembly-stacking protein 2, GRS2, Golgi reassembly-stacking protein of 55 kDa, GRASP55.
What is the protein family that this protein belongs to?
Belongs to the GORASP family.
Protein: HSCA_ECO27
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQAIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: UPPP_SULIY
Sequence: MNFLVSILLGIIQGISEWLPISSKTQELIASHYLLSLDVSIAYTFGLFMEMGSIGSALIYFRQDVKRVFHDKFLLKFLVVVTALTGIVGVPLYVISDKLLQNAYNPSIPMIFLGIALIADGIYIRYSRSRTREFKNLSTKEMILIGIAQGIAALPGVSRSGMTVSTMLVLGINPEDAFHYSYLAYIPAAIGSVGTTLLFTRHHISYVVSLIGIDGIALAVISALLTGLVVIGFLLKIAKTKKVYLIDFMLGGIAVLVSMLGLIIS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRG9_ASPNC
Sequence: MAGVCASSLKLSLPNVLRNALRSEFASDVHQGPASRRILSITPFSQSRYKTQRRNFSASIKPQLCQSAIYLSAQDPSSSASFSSNTAPLGGSENEIRRASTEANASPERNDTKTSHADYLAEAPSSDTPTDKKRTKSSRSKKRSRHEEIPSNPMPQKKPEKWQLHKQALKEKFKDGWNPSKKLSPDALEGIRHLHAVAPEKFTTPVLAEEFKVSPEAIRRILKSKWRPSETEIEDRRKRWERRHDRIWGHLSELGLRPSTKRTRDLTDANQLLYGNNQKKGGKA
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SELU_PSEMY
Sequence: MRENCTDYRDLFINDRPMMDARAPVEFHKGAFPGVINLPLMNDIERQKVGTCYKQHGQQAAIELGHQLVSGRTKAERIEAWASFAKANPDGYLYCFRGGLRSQIVQQWLKSEAGIDYPRVIGGYKAMRGFLLETTEQAVAECDFVLVGGMTGTGKTEVLAQLHNAVDLEAHANHRGSSFGKRASGQPAQIDFENALAIDLLKRRAAGQRQFVLEDEARLIGRCSLPLPLYQGMQHYPLVWLEDSLGDRVERILQAYVVELCAEFVAVEGAEAGFAAFAARLRESLANITRRLGGERYQRLAAIMDQALEEQARDGQVDTHRGWIEALLVEYYDPMYVFQRESKAGRIEFAGEQQAVVEYLRQRSGHFPEAPAS
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: ATPD2_VIBA3
Sequence: MSDYTNIAHPYAKASFDFALGENKLQEWHSMLSILVTVAEEETIAKQISSAEGVHTQQSEELVNLIIHVCQGLVDDHVINLIKVLAENGRLAVIRDLFNLFSDLKDEHERVIPVTVTSSELLTQDQVTSLTAALEKKLERQVEMEQVIDDSLVGGIVIKAGETVIDGSLNTSINRLAHQLHAR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta 2, ATP synthase F(1) sector subunit delta 2, F-type ATPase subunit delta 2, F-ATPase subunit delta 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.