PharMolix/UniProtQA huggingface dataset:
Protein: FIBB_MUNMU
Sequence: QHSTDYDEVEDDRAKLHLDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: RL30_ECOBW
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: SECA_SHEWM
Sequence: MFGKLLTKLFGSRNDRTLKSLGKIVTKINALEDDYEKLTDDELKSKTSDFRNRLESGETLDDVMPEAFAVVREASKRVFEMRHFDVQMLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNGLTGKGVHVITVNDYLARRDAENNRPLFEFLGLSVGINVAGLGQQEKKDAYNADITYGTNNEFGFDYLRDNMAFSPAERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYTKINTLIPHLIRQDKEDTEEEIGEGDYSIDEKAKQVHMTERGQEKVEVLLTERGMLAEGDSLYSAANISLLHHVNAALRAHTLFEKDVDYIVQDNEVIIVDEHTGRTMPGRRWSEGLHQAVEAKEGVHIQNENQTLASITFQNFFRQYDKLAGMTGTADTEAFEFQHIYGLDTVVIPTNRPMVRKDHADLVYLTPDEKYAAIIQDIQGCRERGQPVLVGTVSIEQSELLARLMKQEKIPHEVLNAKFHEREADIVAQAGRTGAVTIATNMAGRGTDIVLGGNWNMEIDALSNPTDEQKAKIKADWQIRHDEVVAAGGLHILGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDSLMRIFASDKVTGMMKRLGMEEGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVYAQRNELMDAESIQDTIVNIQADVVNGLVDQYIPQQSVEELWDVPGLETRLTQEYGLKMPIQEWLDTETDLHEETLRERIVDTWVKAYQSKEEMVGESVLRQFEKAVMLQTLDGLWKEHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQMLESLKHDVISVLSKVQVQAQSDVEEMEERRRQEDAKIQRDYQHAAAEALVGAEEAEALAAHTPTVREGEKVGRNDPCPCGSGRKYKQCHGKLT
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: SURE2_THET2
Sequence: MRILVTNDDGIYSPGLWALAEAASQFGEVFVAAPDTEQSATGHAITIAHPVRAYPHPAPLHGPHFPAYQVRGTPADCVALGLHLFGPVDLVLSGVNLGSNLGHEIWHSGTVAAAKQGYLFGLSAAAFSVPLNGEVPDFAGLRPWLLRTLETLLRLERPFLVNVNLPLRPKGFLWTRQSVRAYEGVVIPGEDPMGRPFYWFASRPLKEAEEGTDRWAVAQGFVSATPLRLDLTDETRLQPALAQE
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE 2, Nucleoside 5'-monophosphate phosphohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IAA27_ARATH
Sequence: MSVSVAAEHDYIGLSEFPTMEATTMSDKTKTRDNNNGLNFKATELRLGLPGSESPERVDSRFLALNKSSCPVSGAKRVFSDAINDSNKWVFSPGSTTATGDVGSGSGPRTSVVKDGKSTTFTKPAVPVKEKKSSATAPASKAQVVGWPPIRSFRKNSMASSQSQKPGNNSETEEAEAKSGPEQPCLYVKVSMEGAPYLRKIDLKTYKSYLELSSALEKMFSCFTIGQFGSHGGCGRDGLNESRLTDLLRGSEYVVTYEDKDSDWMLVGDVPWEMFICSCKKLRIMKSSEAIGLAPRVMEKCRSRN
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin-responsive protein IAA27, Auxin-induced protein 27, Indoleacetic acid-induced protein 27, Phytochrome-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TYSY_BAUCH
Sequence: MKQYLELMRLVRTQGISKVDRTNTGTLSIFGHQMRFNLSHGFPLITTKRCHLRSIIYELLWFLNGDTNINYLRKHHVTIWDEWINEKGDLGPIYGRQWRAWGTADGSYIDQLSDVMLQLKHNPDSRRIIVSAWNVGEIKQMALAPCHVLFQFYVANGVLSCQLYQRSCDMFLGLPFNISSYALLIHMVAQQCDLQLGEFIWTGGDIHLYRNHLKQTDLQLKRNPRPLPQLIIKRRPASLFQYQFDDFYLSGYDPHPAIKAQVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSA_XYLFA
Sequence: MGIRIQELCKQFEDFTALAGIDLDIRQGELLALLGPSGSGKTTLLRIIAGLEHADAGRVLFGDEDATMMSVQARRVGFVFQHYALFKHMSVYENVAFGLRVRRGKARWPESQISARVFELLSLVQLDGLEQRYPMQLSGGQRQRVALARALAIEPRVLLLDEPFGALDAQVRRDLRRWLREIHDRTGLTTVFVTHDQEEALELADRVAILNQGRIEQVASPAEVYNRPSSPFVYSFVGAVNRLPGCVGADGLEVAGIVLSCPPQLSGWGAVDLYVRPEDLVLDAQEGWLAIVLWSQRSGPRMRVRARLEHSAHEVEIELSSATDEYVEGQKLRLIPRHYGVFFSESGG
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LOLD_YERPN
Sequence: MSNHPLLQCINLCKRYQEGQLHTDVLRNVSFAIEPGELMAIVGSSGSGKSTLLHLLGGLDSPTSGEVIYQGRSLNQLSSTAKAELRNRELGFIYQFHHLLPDFTALENVAMPLLIGGSKPAEAQEKAHEMLAAVGLEKRSKHRPSELSGGERQRVAIARSLVNNPSLVLADEPTGNLDQRNADSIFNLLGELNVRQGTAFLVVTHDLQLAKRMSRQLEMRDGQLQHHLTLVGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROA_COXBU
Sequence: MDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGRGGF
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_PARBP
Sequence: MSNINLATLDISEHPNLPSSSAVLFEAKARKKLSFEAIASAIGRNEVATAAIFYGQAKASAEDIVKLSEVLGIDHLYLESLLSGFPDRGKSMTFPPKDPLIYRLFEIVQNYGYAYKAVMNEKFGDGIMSAISFSTKVEKETDLDGNNWAVVTWRGKWLPYSRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: PSBL_CHLMO
Sequence: MARPNPNKQVVELNRTSLYFGLLLIFVLAVLFSSYIFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TNNT2_RABIT
Sequence: MSDLEEVVEEYEEEQEAEEAAAEEEDWREDEDEQEAGEEEEAGGGREAEAETEETQAEEDGQEEEDKEDEDGPVEESKPKPRPFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQTLIEAHFENRKKEEEELVSLKDRIEKRRADAEQLRIRAEREKERQNRLAEERARREEEESRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
What is the function of this protein?
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
What are the official names of this protein?
Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT.
What is the protein family that this protein belongs to?
Belongs to the troponin T family.
Protein: NDHK_SYNE7
Sequence: MVLTNPAEIRNPAAPPEITQGLSENVILTTLDDLYNWARLSSLWPLMYGTACCFIEFAALIGSRFDFDRFGLVPRCSPRQADLLITAGTVTMKMAPALVRLYEQMPEPKYVIAMGACTITGGMFSADSTTTVRGVDKLLPVDVYIPGCPPRPEAIIDAIVKLRKKVANDSIQERGKLLQTNRYYSTTHQMKPTAPLLTGEYLRSAARQAGPLPAAAGAAVAPQLPVTEKEGRDRA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, NAD(P)H dehydrogenase I subunit K, NDH-1 subunit K, NDH-K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THS2_PAPSO
Sequence: MAPLGVSGLVGKLSTELEVDCDAEKYYNMYKHGEDVKKAVPHLCVDVKIISGDPTSSGCIKEWNVNIDGKTIRSVEETTHDDETKTLRHRVFEGDVMKDFKKFDTIMVVNPKPDGNGCVVTRSIEYEKTNENSPTPFDYLQFGHQAIEDMNKYLRDSESN
What is the function of this protein?
Catalyzes the formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated by-products, which are preferentially produced by spontaneous allylic elimination.  No visible activity toward (7S)-salutaridinol (at pH 7).
What are the official names of this protein?
Thebaine synthase 2.
What is the protein family that this protein belongs to?
Belongs to the MLP family.
Protein: CDKL4_MOUSE
Sequence: MEKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLTCAQLLDSAYFESFQEDQMKRKARSEGRSRRRQQNQLLPLIPGSHISPTPDGRKQVVQLKFDHLPNI
What are the official names of this protein?
Cyclin-dependent kinase-like 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTY_BACSU
Sequence: MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWVSEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAVKEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSIWDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCSAFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLETQKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSKLKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP
What is the function of this protein?
Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product.  8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base.  Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs.  May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant.
What are the official names of this protein?
Adenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: RAB7L_PONAB
Sequence: MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC
What is the function of this protein?
The small GTPases Rab are key regulators in vesicle trafficking (By similarity).  Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity).  Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity).  Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity).  Regulates also neuronal process morphology in the intact central nervous system (CNS) (By similarity).
What are the official names of this protein?
Ras-related protein Rab-7L1, Rab-7-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasm, cytoskeleton. Note=Colocalizes with GM130 at the Golgi apparatus (By similarity). Colocalizes with LRRK2 at dynamic tubules emerging from and retracting to the Golgi apparatus (By similarity). Colocalizes with TGN46 at the trans-Golgi network (TGN) (By similarity).
Protein: TRUB_SHEB5
Sequence: MARRPKGRFIDGIVLLDKSTGMSSNFALQRVKRFFNANKAGHTGALDPLATGMLPVCLGEGTKFSQHLLDADKRYLVTAKLGERTDTSDSDGEVVQTRAIDFTEAQLLTALDFFRGETQQVPSMYSALKYQGQPLYKYAREGIEVPRESRPITVFELNFIGLEGDELTLDIHCSKGTYIRTIIDDLGEMLGCGAHVIMLRRTQVAQYPYARMVSLEQLEALVAQAHEQQIDPSILLDPLLLPMDTAVADFPEVNVPDAIAPYLMQGQAVRVPVNAGLKTDELVRITLGDIRRFVGIGTMNEDGLLAPKRLIVIHDEPAETD
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: OTCC_TREDE
Sequence: MLKEIRGKSAKNLRGRSFLKLLDFTTDEIRYLLDLSKNFKDMKRAGIPHRYLEGKNIVLLFEKTSTRTRCSFEVAGYDLGMGVTYLDPNSSQMGHKESIEDTARVLGRMYDGIEYRGFSQELVETLAEYSGVPVWNGLTDLFHPTQMLADLLTIEEKFGYLKGLKFTYMGDARNNVANSLMIACVKMGMHFTACSPKHLFPTEDLVAEAKKIAAQTGGSVTLTENVSEGTKGAHVLYTDIWVSMGEPDSVWEERIKLLKPYQVNKAAMDNADKDAIFLHCLPSFHDLKTTKGQEINKKFGLPEMEVTNEVFESHKSVVFDEAENRMHTIKAVMYATMC
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_XANAC
Sequence: MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLGARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTPRHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPDTIARALENFAGIGRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSEVYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_RENSM
Sequence: MADIDFPAELRALRALRATYDSIERVIDADSLRKDIAVLSEQAGVPDLWDNPAEAQKVTSKLSHAQSKLERLETLTARIDDLEVLVELAESEHDEDSLAEASKELVSLQKSLQELEVVTLLAGEYDEREAVVTIRSGAGGVDAADFAEMLLRMYLRWAERHGYPTSVLDTSYAEEAGLKSATFEVKAPYAFGTLSVEAGTHRLVRISPFDNQGRRQTSFAAVEVIPLIEQTDSIEIPDNDIRVDVFRSSGPGGQSVNTTDSAVRLTHLPTGTVVSMQNEKSQLQNRAAATRVLQSRLLLLKKQQEDAEKKALAGDVKASWGDQMRSYVLNPYQMVKDLRTEHEVGNTSGVLDGDIDDFIDAGIRWRANNRNAAE
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_MYCGI
Sequence: MAKNSKIVKNERRLVLVARHAERRAELKAIISSPSTPADARAAAQSELNRQPRDASPVRVRNRDAVDGRPRGHLRKFGLSRMRVRELAHRGQLPGVRKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: MCR_SHEEP
Sequence: LSTISQALTPSPSMILETIQPEIVYAGYDSSKPNTADNLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTYPQFLYFPPDLVFNEKKMHHSAMFELCQGMHHILLQFVRLHLTSEEYSIIKVLLLLSTIPKDGLKTQAVFEEMRTNNIKELRKMVTKCPNNFGQSWQSFYQLTKLLDSMHELVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAQTLYFHRK
What is the function of this protein?
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol.  Binds to mineralocorticoid response elements (MRE) and transactivates target genes.  The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
What are the official names of this protein?
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding.
Protein: ERO1A_RAT
Sequence: MGRGWGLLVGLLGVVWLLRSGQGEEQQQETAAQRCFCQVSGYLDDCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLRKPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKYSKEANLLEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDSFCEVDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQRPLASGQGKHKENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDNWLEKKWGHNVTEFQQRFDGVLTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDVENKELLLEILHEVKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFQLTRQEIVSLFNAFGRISTSVRELENFRHLLQNVH
What is the function of this protein?
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.  Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation.  Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell.  Required for the proper folding of immunoglobulins.  Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
What are the official names of this protein?
ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, Endoplasmic reticulum oxidoreductase alpha, Endoplasmic reticulum oxidoreductin-1-like protein, Global ischemia-induced protein 11, Oxidoreductin-1-L-alpha.
What is the protein family that this protein belongs to?
Belongs to the EROs family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Golgi apparatus lumen. Secreted. Cell projection, dendrite. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum (By similarity). In neurons, it localizes to dendrites (PubMed:12694393).
Protein: MURA_COREF
Sequence: MGGVKDKFLVKGGARLQGSVRVDGAKNSVLKLMAAALLAEGTTTLTNCPEILDVPLMRDVLVGLGCEVEIDGHTVTIHTPAELKSDADFPAVTQFRASVCVLGPLTARCGRAVVSLPGGDAIGSRPLDMHQSGLEQLGATTRTQHGAVVAEADKLVGAEISLDFPSVGATENILMASVMAEGQTTLDNAAREPEIVDLCRMLRSMGADIEGEGSPKITINGVEKLHPTSHEVIGDRIVAGTWAFAAAMTRGDVTVGGIAPRYLHLPLEKLKLAGAQVDTFENGFRVVMNKRPKSTDYQTLPFPGFPTDLQPMAIGLNAIADGVAVVTENVFESRFRFVDEMQRLGADTSVDGHHVVIRGIEELSSTTVWSSDIRAGAGLVIAALCAEGTTEVRDVFHIDRGYPNFVENLQALGADIQRVVA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.