PharMolix/UniProtQA huggingface dataset:
Protein: AQPZ_FLAJO
Sequence: MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGHFNPAVSFGLWAGGRFSAKD
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPE_METEP
Sequence: MSDHSPLALAQALIRCPSVTPEEGGALSFLADRLSRAGFSVERPVFSEPGTPDIQNLYARIGTAGPVLVFAGHTDVVPPGEVGSWTHGPFSGEVAEGFLYGRGAVDMKGGIACMLAATLAFLDRHGPDFGGSIAFLVTGDEEGPAVNGTVKLLDWAKARGERFDHCLLGEPTNPDTLGEMIKIGRRGSLTGRITVHGRQGHVAYPHRAENPIPGLLRLASALTADPLDGGTAHFDASNLEFTTIDVGNPATNVIPASAKAVFNVRFNDDWTADTLGAEIRRRLEAAAGNAVRFSLDLQPSNSPAFLTQPDAFVDRVADAIEAETGRRPALSTTGGTSDARFIKDACPVIEFGLVGRTMHETDERVAVADLDRLTAIYGRVLDAYF
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: UBE3C_HUMAN
Sequence: MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENTYLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASASCHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24811749, PubMed:24158444, PubMed:25752573, PubMed:25752577, PubMed:34239127, PubMed:33637724, PubMed:32039437).  Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9575161, PubMed:32039437).  Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563).  Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563).  Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724).  Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577).  Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755).  Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129).
What are the official names of this protein?
Ubiquitin-protein ligase E3C, HECT-type ubiquitin transferase E3C, Homologous to E6AP carboxyl terminus homologous protein 2, HectH2, RTA-associated ubiquitin ligase, RAUL.
What is the protein family that this protein belongs to?
Belongs to the UBE3C family.
Protein: NA14_ANTXA
Sequence: GVPCLCDSDGPSVRGNSLSGIIWLFGCPSGWHNCRDHGPTIGWCCKK
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction.  Thus it may strongly stimulate mammalian cardiac muscle contraction.
What are the official names of this protein?
Delta-actitoxin-Axm1f, Delta-AITX-Axm1f, PCR2-10, Toxin PCR4.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: CAN15_MOUSE
Sequence: MATVGEWSCARCTFLNPAGQRQCSICEAPRHKPDLDQILRLSVEEQKWPCARCTFRNFLGKEACEVCGFTPEPVPGAPLLPIINGVLPKPPTILVEPKGSGKEEAGPVRTAGLVATEPARGRPEGEEEREERGEEEEKEQEGEGERAEPGSGWACQRCTLHNTPVASSCSACGGPRKLSLPRIPPEALVVPEVVAPTGFHVVPAPSQPVLPGEGAEADSPSTSQGPTSTDQEPPRVPLFSPFSPTLQNNPVPRSRREVPPQLQPPVPEAVQSSASTSSKGPQQGPGRAAAGASRLAELLSGKELLPGKRLSVLEEEVPESSPARCESCSDVIDLAGDIVRYTPASPSSPDFTTWSCARCTLRNPTTAPRCSVCGGSKLHGFQEHSEPPTHCPDCGANKPGPCVGSCGRAPSAHKAVRLLPDRPGQWACPACTLINTPRAKHCAACHTPQLLVTQCRGATPLRRRESMHVEKRRQTDEGEAKALWENIVAFCRENSVNFVDDSFPPGPASVGFPVGDSVQQRVKQWLRPHEINCSVFRDHGTPWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGFLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQVSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYESLGLRPRHAYSVLDVRDVQGSRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRAELMPHGSSEGVFWMEYSDFIRYFDSVDICKVHSDWQEARVQGCFPSTAGGPVGVTALTVLERASLEFALFQEGSRRSDSVDSHLLDLCILVFRATFGTGGRLSLGRLLAHSKRAVKKFVNCDVMLEPGEYAVVCCAFNHWNPAPPGPPAQASSPSAGVPRGAPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKSYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASRGTHSPPLTPDVAGLHGPRPL
What are the official names of this protein?
Calpain-15, Small optic lobes homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
Protein: PHHA_EMENI
Sequence: MTTDSYPKKYDIVIVGAGPVGILLSLCMSRWGYKVKHIDNRPVPTATGRADGIQPRSTEILRNLGLKRKIMAYDPAKVYDVSFWDPRPDGSGIMRTGNWPSCPRFIDTRYPFTTLVHQGKIETVFLDEIKKAGTTVERPWTIIGFKNDGLDATYPVQVQLKCLDTNVVETVRAKYLFSGEGARSFVREQLGIQIRHKDPISYVWGVMDGVVRTDFPDIQTKCTIHSDAGSIMVIPREDDMVRLYVQIASSSDPDFNPRKTATAEEVQNVAKKILKPYYIEWDRVEWYSVYPIGQGISEKYTLDERVFMGGDACHTHSPKAGQGMNTAFHDALNMAWKLHAVESGLAQRSILSTYETERKNIAETLLDFDNKYAALFSKRRPNAGEVGEAATAETGRSAEEDPFVKTFKDSCEFTSGYGVAYLPNIFNWDPSHPAKSPLFDVPGINLVTGKAFTPSTVTRLADSNFVHLEQEIPANGAFRIFIFAGRQSRSKKAIADFAANLEKERSFLSAYRRSDIGEISFFERHNPHSKLFTLCLIYAEKKNDIDMDSIPQILRDYRYHIYSDDIPDVRVPNATYAAHEKLGFDPEKGGVVVTRPDSHIACTVQLAEGSGTVDALNAYFGSFSTKPLGQEQASRL
What is the function of this protein?
FAD-dependent monooxygenase; part of the benzoic acid degradation pathway also known as the protocatechuic acid pathway (PubMed:25479309).  Benzoic acid debradation begins with the conversion of benzoic acid into 4-hydroxybenzoic acid through hydroxylation by the benzoate-4-monooxygenase bphA, and its partner NADPH-cytochrome P450 reductase cprA which act as a mediator in electron donation from NADPH (By similarity).  4-Hydroxybenzoic acid is then converted into 3,4-dihydroxybenzoic acid (also called protocatechuic acid) by the p-hydroxybenzoate-m-hydroxylase phhA (Probable).  Protocatechuic acid is converted into 3-carboxy-cis,cis-muconic acid by the intradiol ring-cleavage dioxygenase prcA, which is further metabolized through the 3-oxoadipate pathway to finally enter the tricarboxylic acid cycle (TCA) (Probable).
What are the official names of this protein?
p-hydroxybenzoate-m-hydroxylase, 4-hydroxybenzoate-3-monooxygenase phhA, FAD-dependent monooxygenase phhA.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS6_ENTFA
Sequence: MSQDTKYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTAGAINEFDRLAKINDDIIRHMIVKVEA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RPOZ_COXB1
Sequence: MARVTVEDCLEHVENRFDLVLKAAKRAHILELGGAEPMVPRDNDKPAVLALREIAAGYDVTREGQEQETEEVDVDRNVLAETAKMNKAVASQKESEV
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RL11_CELJU
Sequence: MAKKVTAYVKLQVAAGKANPSPPVGPALGQHGVNIMEFCKAFNAQTQGMEVGAPVPVIISVYSDRSFTFVMKTPPASFLLKKAAGITSGSGRPNTNKVGKVNRAQLEAIATTKLPDLTAADMDAAVRTIAGSARSMGLDVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RR12B_POPTR
Sequence: MPTIKQLIRNTRQPIRNVTKSPALGGCPQRRGTCTRVYSGSKGDLSVNFSTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSQYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12-B, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1944_YERPP
Sequence: MNLQQQLAYCQQHQQRLQLRHFDNETAWQLGEKIKRQAEKQGVALAIDITVNHQTLFSYAMAGTCAENQDWLRRKRNVVELLSTSSYAAGLMLQQRETSLDARYGVSLRDYAALGGAFPLQIKQAGIIGSVNVSGAPHLDDHNLLLQVLADFVGLPTGSIELLTPLTPLSA
What are the official names of this protein?
UPF0303 protein YPDSF_1944.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: YVDE_VACCC
Sequence: MNIYCRYSSLTLANFLCLLMKLSISCPNSLELKYLDIFCWKVVNGRVTTLSYNIYPFLERSVINGICFTELDTNRVPILR
What are the official names of this protein?
Uncharacterized 9.3 kDa protein.
Protein: RUVA_RHILO
Sequence: MIGKLKGTLDEIDEDHCLVDIHGVGYVAYCSARTLAALPSPGEAVVLFIETYVREDMLRLYGFQSALEREWFRLLLNNVPGVGAKVALAILSTLAPADLANAIALRDIAMVSRAPGVGKKVAERIVTELKNKAPAYAGAASGTIGLKQELGEGVAPAPITDAVSALVNLGYSRDTAANAVAAALKTAGEDADASKLIRFGLKELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ASPD_ACIB5
Sequence: MKKLMMIGFGAMAAEVYAHLPQDLQLKWIVVPSRSIEKVQSQVSSDIQVISDIEQCDGTPDYVIEVAGQAAVKEHAQKVLAKGWTIGLISVGTLADSEFLVQLKQTAEKNDAHLHLLAGAIAGIDGISAAKEGGLQKVTYKGCKSPKSWKGSYAEQLVDLDHVSEPTVFFTGTAREAAMKFPANANVAATIALAGLGMDETMVELTVDPTINKNKHTIVAEGGFGQMTIELVGVPLPSNPKTSTLAALSVIRACRNSVEAIQI
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: HEM6_SALPC
Sequence: MKPDAHHVKQFLLRLQDDICQKLSAVDGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQRGIGGLFFDDLNTPDFDHCFDFMQAVGNGYTRAYLPIVERRKAMVWGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUC1_MESAU
Sequence: MTPGIRAPFLLTLLLALVTDPNSVALSQDTSSSSTLNTTPVHSGSSAPATSSAVDSATTPGHSGSSAPPTSSAVNSATTPGHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPVTSSAVDSATTPVHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPPTSSVVNSATTPVHSGSSAPPTSSAVNLATTPVHSGSSTPATNSTTDSATTPVPPGSSMQTTEAISGSANTPIHNGSLVPTTSSALVPTTSAAHSGASAMTNSSESDLATTPIDSGTSISTTKAPATTPVHNGSLVPTTSSVLGSATTLIHNDTSTMATTTPVGNGTQSSVPSRHPVTPTPPAVSSNSTIALSTYYSTALSPAFSSHAAPQVSVGVSFFLLSFHIWNHQFNSSLEDPSSNYYQELKRNVSGLFLQVFSRAFLGISTIEFRSGSVVVDSTVIFREGAVNASEVKSQLLQHEQEAEEYNLAISKINVGEMQFPSSAQSWPGVPGWGIALLVLVCILVALAIVYLIALAVCQCRRKNYGQLDIFPIQDSYHPMSEYPTYHTHGRYVPPGSTKRSPYEEVSAGNGSSLSYTNPVVATTSANL
What is the function of this protein?
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions.  Modulates signaling in ERK, Src and NF-kappaB pathways.  In activated T-cells, influences directly or indirectly the Ras/MAPK pathway.  Promotes tumor progression.  Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response.  Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity (By similarity).
What are the official names of this protein?
Mucin-1, MUC-1.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions (By similarity). SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.
Protein: BTDA_PAPAN
Sequence: MRTFALLTAMLLLVALHAQAEARQARADEAAAQQQPGADDQGMAHSFTWPENAALPLSESAKGLRCVCTRGFCRLL
What is the function of this protein?
BTD-1, BTD-3, BTD-4 and BTD-7 have antimicrobial activity against the Gram-negative bacterium E. coli ML35, the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820.  BTD-3 is more effective against E. coli than BTD-1, BTD-4 and BTD-7.
What are the official names of this protein?
Theta defensin subunit A, BTD-a, BTD-1 subunit 1, BTD-3, BTD-4 subunit 1, BTD-7 subunit 1.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family. Theta subfamily.
Protein: PTP69_DROME
Sequence: MALLYRRMSMLLNIILAYIFLCAICVQGSVKQEWAEIGKNVSLECASENEAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTASTITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHHIAESTLD
What is the function of this protein?
Possible cell adhesion receptor.
What are the official names of this protein?
Tyrosine-protein phosphatase 69D, Protein-tyrosine-phosphate phosphohydrolase, DPTP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ARP4_DEBHA
Sequence: MSSSGNNASVYGGDEINAIVLDSSSFHTRIGYAGDDFPKIITPSSYASPNEDAMELDNKKKNGKSKSSKIFGESINIPRSNHNVSPILKDSVIIDWEAAIEQYHYYFDDVLTLNYKEQPILITEPVWCTPQYRQTLLETFYENFDFPALFLAKSPTCISFQQGRPNCLVVDIGHDSVSVTPVIDGISLLKNSMKTNYGGQYLNDQIEDMLTHKFSGVNFENRYRIKSKTPTVYPEESKYTVRDLSENITQSFDDYQRQNIWHEFKETMLEVPEKKFNTSNTSQANSLKEIYSQDSNKRLFELPTGQSLELCLERFQLADSLFDPQSYKFNNPDLATKYPPSNGELSLTNSYDDYKPLKRARKAESNQSTPPPSDAKKPSSKTSQIRGLTHLITHTLSTIDIDLRSSVAHNIIVTGGVSLIPQLTERLYSELSNSNPGLKIRLHAVGNSSERFNQAWIGGSVLASLGTFHQMWVSKQEYEEAGAERILNQRFR
What is the function of this protein?
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Is required for NuA4 complex integrity.  Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
What are the official names of this protein?
Actin-related protein 4, Actin-like protein ARP4, Actin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNX3_ASPOR
Sequence: MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW
What is the function of this protein?
Required for retention of late Golgi membrane proteins.  Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment.  Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
What are the official names of this protein?
Sorting nexin-3.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VE2_HPV17
Sequence: MDNLSERFNVLQENLMDIYESGQEDIETQIKHWQLLRQEQVLFYYARKNGVMRVGYQPVPPLATSEAKAKDAIGMVLLLQSLQKSPYGKEPWTLTQTSLETVRSPPANCFKKGPQNIEVMFDNDPENLMSYTVWSFIYYQNLDDTWNKVEGRVDYHGAYYMEGSLKVYYIQFEVDAARFGKTGRWEVHVNEDTIFAPVTSSSPAAGEGTDASPINAASRSSPARGLSATSVSTRTTQRTSPRRYRRKASSPTATTTRHKRQDIRRSRSTSRGRQAISRGGERRQRRRERSYSRDSSRSPNRGRGGSSGGPTTRSQSRSLSRSRSRSRSRSRGSSAGGGVAPEQVGKSVRSVGRNPGGRLTRLLEEARDPPVILLRGEANKLKCFRYRAKKRYGSLVKYYSTTWSWVGANTNDRIGRSRMLLAFNTYDERELFIQKMKLPPGVDWSLGHLDDL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YB056_YEAST
Sequence: MPPAQLQHRSIRHRQHKTFAIAEQQSPQLQQQQQSFLGGGGPCCMYIGCGCG
What are the official names of this protein?
Putative uncharacterized protein YBR056C-B.
Protein: APX3_ORYSI
Sequence: MSAAPVVDAEYMAEVERARRDLRALIASKSCAPIMLRLAWHDAGTYDKATKTGGPNGSIRFPQEYSHAANAGIKIAIDLLEPMKQRHPKITYADLYQLAGVVAVEVTGGPTIDYVPGRRDSSDSPEEGRLPDAKKGAAHLREVFYRMGLSDKDIVALSGGHTLGKARPERSGFDGAWTKDPLKFDNSYFIELLKENSEGLLKLPTDKALVEDPTFRRYVELYAKDEDAFFRDYAESHKKLSELGFTPPRSAFIYKSCQKPKSLLMQTAAGVAVAAAVVAWAYLCESNKRLG
What is the function of this protein?
Plays a key role in hydrogen peroxide removal.
What are the official names of this protein?
Probable L-ascorbate peroxidase 3, OsAPx03.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HBA_PHACA
Sequence: VLSASDKTNVKGVFAKVGGSAEAYGAETLERMFTAYPQTKTYFPHFDLHHGSAQIKAHGKKVAAALVEAANHIDDIAGALSKLSDLHAQKLRVDPVNFKLLGHCFLVVVAIHHPTLLTPEVHASLDKFMCAVAKELTAKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-A, Alpha-A-globin, Hemoglobin alpha-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.