PharMolix/UniProtQA huggingface dataset:
Protein: EPN2_HUMAN
Sequence: MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL
What is the function of this protein?
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
What are the official names of this protein?
Epsin-2, EPS-15-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the epsin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Protein: PACN2_XENLA
Sequence: MSGTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCNDLMNCIHERARIEKVYAQQLTEWAKRWKQLVERGPQYGTVEKAWHNLMTEAEKVSELHLEVKNALMNEDFEKIKNWQKEAFHKQMMGGFKETKEADDGFRKAQKPWAKKLKEVEAAKKSYHAACKEEKLATSRETNSKADPAMNPEQLKKLQDKVEKSKQDSQKTKEKYEKSLKDLDGTTPQYMENMEQVFEQCQQFEDKRLSFFREVLLEVEKHLDLSNVESYASIYRELEYAIKSADAMEDLKWFRNNHGPGMSMNWPQFEDWSADLNRTLSRREKKKPTDGVTLTGISQSGEQSSIQNQHSSHLSVQSAQSTNNPFEDEEETVSINETENKKIENVGSYEKTHPAEWSDDESNNPFNPSDTNGDNNPFDEDALTTLEVRVRALYDYDGQELDELSFKAGEELTKIEDEDEQGWCKGRLEGGQVGLYPANYVESVQ
What is the function of this protein?
Regulates the morphogenesis and endocytosis of caveolae (By similarity).  Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds.  Plays a role in intracellular vesicle-mediated transport.  Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
What are the official names of this protein?
Protein kinase C and casein kinase substrate in neurons protein 2, x-PACSIN2.
What is the protein family that this protein belongs to?
Belongs to the PACSIN family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasmic vesicle. Cell projection, ruffle membrane. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Membrane, caveola. Note=Detected at the neck of flask- shaped caveolae.
Protein: HEMH_RALSO
Sequence: MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFILNVLILPLRSRASAHKYETVWLREANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMRYGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFDEVFRVMGQMRNQPELRLVKHFHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGRLLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKDFHYIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEASRTRAQSKGAAA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA_XYLFT
Sequence: MTALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIHINTHHNTTAPERTRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPSNALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLWLLDEPYANLDPEGITLLNHILTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1029_SHESW
Sequence: MLDTKFDELMDFPCAFPFKVVGDAHEALTDRVVAVVQKHAPGDYAPTTKASSKGSYYSITIRVTVTSKDHIETLYTELAAIEGVRRVL
What are the official names of this protein?
UPF0250 protein Sputw3181_1029.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: UXUA_SORC5
Sequence: MKMTFRWYGENDPVKLEYIRQIPGIYGIVSAIYDVPVGEVWPVERLQALRARVEGVGLRFEVVESVPVHEDIKLGKPARERLIDNFCQNIRNCAAAGVKVICYNFMPVFDWTRTEMARELPDGSLTLAFDAAAVAEIDPEQGISLPGWDSSYRPEQLRAVLDEYKNVSEEALWEHLEHFLRRIIPVAEEVGVRMAMHPDDPPRPIFGLPRIVKNRDDLMRLVKTVDSPANGITLCSGSLGADLCNNIVSLVREFGGMGRIPFGHLRNVAVQEDGTFFESAHLSCEGSLDMAAIVKAYHDVGFDGYVRPDHGRMIWGETGKPGYGLYDRALGLVYLNGLWEATCKLSPGPAAKVPAPG
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: LPAKS_PSESP
Sequence: MKLNALSTATHGSRSSPVKLWKFSTSFLLAASIIVSGQSWAAETAKPATDATKAANDALLKELPFDDKTSFDLAHKGFIAPLPAEPIKGEKGNMIWDPSKYGFIKEGEAAPDTTNPSLWRQSQLINISGLFEVTDGIYQVRNYDLSNMTIVEGKDGITIFDPLISQETAKAALDLYYKHRPKKPVVAVIYTHSHVDHYGGVRGVVDEADVKAGKVKIYAPLGFLEHAVAENVMAGTAMSRRASYMYGNLLPPDAKGQLGAGLGTTTSAGTVTLIPPTDIIKETGETHVIDGLTYEFMYAPGSEAPAEMLYYIKEKKALNAAEDSTHTLHNTYSLRGAKIRDPLAWSKYLNEALKLWGDDVQVMYAMHHWPVWGNKEVREQLSLQRDMYRYINDETLRLANKGYTMTEIAEQVKLPKKIATKFSNRGYYGSLNHNVKATYVLYLGWFIGNPATLWELPPADKAKRYVEMMGGADAVLKKAKEYYDKGDFRWVAEVVNHVVFAEPNNQAAKNMQADALEQLGYQAESGPWRNFYLTGAQELRNGVQQLPTPDTASPDTVKAMDLDLFFDFLAMRLKGPDVADKHITLNLDFTDLKQKYTLEMVNGVLNHTEGMQAKNADATVTLTRETLNNVMLKQTTLKDAESSGDIKIEGDKGKLEELMSYMDNFDFWFNIVTP
What is the function of this protein?
Alkylsulfatase that cleaves primary alkyl sulfates such as sodium octyl sulfate and the widely used detergent sodium dodecyl sulfate (SDS).
What are the official names of this protein?
Linear primary-alkylsulfatase, Primary type-III alkylsulfatase, Type III linear primary-alkylsulfatase.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YCX3_MESVI
Sequence: MYFHILILNHTLMKKKSYSTYNLTIWQHIWTIILLFISISCIKQYNFSFQSFNRGEYSNFTTFDSFNKKQVCNLISFDNALLKILLKNKICINTIEKQPIYKQIQICPDFCRLIFTSHSYNPIGIINNVSDLSIIGFVDLYGNKWEEGSAFIAHKYFLENQKLPNIIGINNMNSYKLAQMCFVLKNNKSTHSFVIDLRKEKNIILINNLGKVNIGNDFASLIKKLIFLKSFTSICKEGDDILSKIDINNLSRPIVQYSSYL
What are the official names of this protein?
Uncharacterized 30.4 kDa protein in rpoZ-ycf20 intergenic region.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SURE_CHLMU
Sequence: MTKEPRFKILITNDDGIKAKGISLLVSLLRDANFADLYVVAPLEEQSGRSMAFSLIGPTAVEPFDYPQKVQEAWAVVGTPVDCVKLAIGELFKDNPPDLVLSGINNGKNSGRNLYYSATVGAIREANLHGIPAIALSQCENISFFQEAQMSSLIRALCEFTVSHKHANPLGFNVTFPASSDNSPWKGIRFTLSGDEFLFGIPRLIRTEGNRRYYTLYDMQDKVSEDLSDEYLALANNYITAVPLISKNTPLATLSEEELAFLKESFEQSVQWDSSLNFEEDLA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR19_CARPA
Sequence: MTRSLKKNPFVANHLLRKIEKLNTKAEKEIIITWSRASTIIPTMIGHTIAIHNGREHLPVYITDRMVGHKLGEFAPTINFRGHAKNDNKSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GATA_NOSP7
Sequence: MASIRELHQQLVKKERSAVEITQEALERIEALEPKLHSFLCVTAERALEQAGAVDAKIAAGEEIGLLAGIPVGIKDNLCTKGIPTTCASRILENFVPPYESTATQKLADAGAVMVGKTNLDEFAMGSSTENSAYQVTANPWNLSRVPGGSSGGSAAAVSSQECVVALGSDTGGSIRQPASFCGVVGMKPTYGLVSRYGLVAYASSLDQIGPFANTVEDAAILLNAIAGHDPKDSTSLKVAIPNYAASFKPDFKPRGQLRIGIVKETFGEGLDSVVEQAVTKAVDVLQSLGAEIHIISCPRFRYGLPTYYIIAPSEASANLARYDGVKYGYRAPDADNLLSMYTRTRATGFGTEVKRRIMIGTYALSAGYYDAYYLKAQKVRTLIKEDFEKAFRVVDVLVCPTSPTTAFKAGEKTTDPLSMYLTDLMTIPVNLAGLPSLSLPCGFDDQGLPIGLQLIGNVLREDQLFQVAYAYEQATTWHLRKPQIS
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: Y2300_PAEAT
Sequence: MSGHSKWATTKHKKAIIDGRRAKSFAKLIKNIEVAARMGGPDLAGNPGLELAVTKAKKTSVPNDNIDRAIKRGAGLTGEVVDYTEIMYEARGPQGSALLIECLTDNKNRAASEVRLAISRNGGTIADPGSVSYLFARKGVVVLPKNGLSEDDILMAVLEAGAEEVKDSGENWEIHSEPSDLQAIRDALKEAGIDYETDEAEFVPSMQVDLDVDGAKKFMKLVDALEDLDDVQNVYSNADLSEEVQAALDSE
What are the official names of this protein?
Probable transcriptional regulatory protein AAur_2300.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUQ_XANAC
Sequence: MPSPPYLGRFAPSPTGPLHFGSLLAAFGSWLLARHAGGQWCVRIEDIDPPRAEPGACERQLRTLAAFGLHSDLPVIRQSERDAAYTAAITRLLQTGQAFECSCSRADLAGMGGIHHACVAPLGERRAVRLRVPPQPPVGFDDALQGPVLQDVYAEVGDVVLRRADGYWAYQLAVVVDDAAQGITDVVRGADLLDSTPRQMVLQRALGLPQPRYLHLPLMLDRDGRKLSKSHDAPALDDADPLPALHAAWAALGQESDALPRHAAVETVLQHAVQHFSPRLLPRQRELDLDERASGLQRD
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: PUIB_WHEAT
Sequence: MKTLFLLALLALVASTTFAQYSEVGGWYNEVGGGGGSQQCPQERPKLSSCKDYVMERCFTMKDFPVTWPTKWWKGGCEHEVREKCCKQLSQIAPQCRCDSIRRVIQGRLGGFLGIWRGEVFKQLQRAQSLPSKCNMGADCKFPSGYYW
What is the function of this protein?
Acts as a membranotoxin, probably through its antibacterial and antifungal activities, contributing to the defense mechanism of the plant against predators.  Forms monovalent cation-selective ion channels in membranes.  Has antibacterial activity against the Gram-positive bacteria S. aureus and C. michiganensis, and the Gram-negative bacteria E. coli, P. syringae pv phaseoli, A. tumefaciens and E. carotovora subsp carotovora.  Acts synergistically with PINA against bacteria.  Contributes to grain texture and hardness.
What are the official names of this protein?
Puroindoline-B.
What are the subcellular locations of this protein?
Membrane. Secreted, extracellular space.
Protein: Y983_THEMA
Sequence: MAKYQVTKTLDVRGEVCPVPDVETKRALQNMKPGEILEVWIDYPMSKERIPETVKKLGHEVLEIEEVGPSEWKIYIKVK
What are the official names of this protein?
Putative sulfur carrier protein TM_0983.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
Protein: TBA8_BOVIN
Sequence: MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGAQASKIHDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTYRHLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
What are the official names of this protein?
Tubulin alpha-8 chain, Alpha-tubulin 8.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OPPA_LACLC
Sequence: DHMTTPPGANDWDITDGSWSLASEPSQQDLFSASAPYNFGHFNDSEITKDLNDIDSAKSENPTYRKAAFVKYQEDMNKKAYVVPTNFSLSYTPVNKRVVGMTLDYGAMDTWSEIGVSSAKLATK
What is the function of this protein?
This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.
What are the official names of this protein?
Oligopeptide-binding protein OppA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PETN_GLOVI
Sequence: MDPTVGWIALLAFFVVSIALVVWGRNGF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HEXA_RAT
Sequence: MAGCRLWVSLLLAAALACLATALWPWPQYIQTSHRRYTLYPNNFQFRYHAGSAAQAGCVVLDEAFRRYRSLLFGSGSWPRPSFSKKQQPLGKNILMVSVVTAECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTPCYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQAQPISVGYCEQEFEHT
What is the function of this protein?
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides.  The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2.  The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide.  Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
What are the official names of this protein?
Beta-hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: ARGJ_BORPE
Sequence: MAVNLQIPSESEILPVAGVEIGVAEAGIRKAGRRDLTVFRLAPGSAVAGVFTRNRFRAAPVQVCEAHLAQGGPIRALVVNTGNANAGTGAPGLKNAQDTCAALGKLLDVPAEQILPFSTGVILEPLPMDRLTAGLPAAVADLRADGWYGAAHGIMTTDTLPKIHSRRVNIGGKTVTITGISKGAGMIRPNMATMLGFLATDAGIAQPLLRQLAIELADVSFNRITVDGDTSTNDSFILIATGQAGVTVDSAGDAAYAALRDALAAAATDLAQKIVRDAEGATKFMTIRVEEAGNTEEALKVAYAVAHSPLVKTAFFASDPNLGRILAAIGYAGIDDLDVSRLRLWLGDVLVAVDGGRNPDYQEADGQRVMKQAEILVRIALGRGQVADTVYTCDFSHEYVTINADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMA_AROAE
Sequence: MPLPAIDPAEYASQLADKVTQFKHAFTPFAVPEPTVFPSAPLHYRLRAEFRMWHDGERIDYAMFDPAEPKQPIAIEQFDIAAEPICAAMPRLRERLRASETLKRRLFQVEFLATLSGELMISLIYHRPLDESWEAAARELAAELNVQLIGRSRKQKIVLDRDWVLERFALDGRPLQYKQIEGSFTQPNGGVNRQMLGWACEQVRGVGGDLLELYCGNGNFTVALAPLFDRVLATEVSKTSVEAAHYNLAANDIGNVAMVRMSSDEISAALARTREFRRMKDVDLDRYRFSTLFVDPPRSGLDAPTVELARGFDRILYISCNPQTLQENVAALQATHGIAGAAVFDQFPYTRHLECGLLLTRRGGPRAP
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: AHR_MUSSI
Sequence: MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSMSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPAPLDSHFLMGSVSKCGSWQDSFAATGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYSIMRNLGIDFEDIRSMQNEEFFRTDSTAAAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSAMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQAFLSKVQSRGVFNETYSSDLSSIGHAAQTTGHLHHLAEAQPLPDITPGGFL
What is the function of this protein?
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer.  Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation.  Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).  Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.  Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists.  Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands.  Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity.  Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.  Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1.  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
What are the official names of this protein?
Aryl hydrocarbon receptor, Ah receptor, AhR.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Protein: RS19_SALDC
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HSLV_PSEA8
Sequence: MTTIVSVRRNGKVVMGGDGQVSLGNTVMKGNAKKVRRLYHGQVLAGFAGATADAFTLFERFEQQLEKHQGHLVRAAVELAKDWRTDRSLSRLEAMLAVANKDASLIITGNGDVVEPEHGLIAMGSGGGFAQAAALALLQHNAELSAREVAETALNIAGSICVFTNQNLTIEELDSAV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_BOMMO
Sequence: MQNDAGEFVDLYCPRKCSASNRLIHAKDHASVQLVIADVDPATGRAADTSKMYVVCGAIRRMGESDDCIVRLTKKDGILAKNY
What are the official names of this protein?
40S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: LIS1_TALSN
Sequence: MSRLLTIRQAEELHKSIIAYLSANNLTNAAAALRAELGLSEEVFDTGTMVKYETLLEKKWTSIVRLQKKIMDLEARTVALQTELNNATPTSLSKRNQDPASWLPKVPARYSLESHRSTVNCVAFHPKFSSIASGSDDSMIKIWDWELGELEATLKGHTRSVLGVDYGTAQSGVLLASCSSDLSIKIWNPSDDYKNIRTLLGHEHSVSAVRFIPGRNLLVSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLLSAGDDITARLWDITNISNPEAKLTMVGHDHVIECCAVAPQTSYQYLAPMAGVKKEAVSKLGAVEFIATGSRDKTIKVWDRRGSCLMTLVGHDNWIRAIVFHPGGKYLLSSSDDRSIRCWDLSQDGKCVKTLSEAHGHFISSLRWAPNVVKEVANNADSGNGKTDSNGLLKGKDNPPNVQIRCVVASAGVDCKLNIYAN
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein nudF, Lissencephaly-1 homolog, LIS-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.