PharMolix/UniProtQA huggingface dataset:
Protein: AUSR_PENBI
Sequence: MHSFSTLPNHRIGLYILWTIPVLFVIFKLLAPAKCSLPIVNGRRWFEIGQYQARRRFSLDGRGIILKGLQKARAFRVVSQKGPKIILGPEYANEVKSHPACNADVFIAKEFHAHVSGFEVLRPQHVMKDAIRLKLTRSIGALMRPISDETTLILETQWGNSNCWHELDLKSTIAALVSRVSAVMFVGEELGRDQKWLSIVTNYSSDMFVADLDLCKWPEILRPIATYFLSSCGKLRRHIQEAALMLDPILSEGNSTHGNKQNFLDWFEEIAGGRKYNPVLAQISLAAAAIDTTSDLIIQTLTDICRFPDSEKLQEELREEMVRVLRADGWEKSAMYNLKLLDSVLKETQRVKPVVVFGMGRYVTEQITLHDGTVIPKGETINVVNTRVWDSAVYENPLEWDPYRFLRRRDSGDHAAHLVSPTPDHMGFGLGKHSCPGRFFAATKIKILLCHILLKYDVKISDEASSKVVSSGNFLFPDATLRISVRRRQENLSIWD
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausR, Austinoid biosynthesis clusters protein R.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CCME_SALTI
Sequence: MNLRRKNRLWVVCAVLAGLALTTALVLYALRANIDLFYTPGEILYGKRETQQLPAVGQRLRVGGMVMPGSVRRDPDSLKVNFSLYDAEGSVTVSYEGILPDLFREGQGVVVQGTLEKGNHVLAHEVLAKHDENYTPPEVEKAMQENHRRPQRADKDTSS
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: XERD_BRUA2
Sequence: MTMRASLAIENFLEMMSAERGAAQNTLESYRRDLEAAAEELAAKGVNLAEAETGHIRMTLDTMAAQGFAPTSQARRLSALRQFFRFLYSEGFRQDDPTGILYAPKKQKPLPKIMSVENVGKLLDRAALEANEAAEPGERIKALRLHALLETLYATGLRVSELVGLPVTVARTDHRFLLVRGKGSKDRMVPLSRKARDALQKFLTLRDSLPGSDDNPWLFPAFSESGHLARQVFARELKGLAARAGLAASSASPHVLRHAFASHLLQNGADLRTVQQLLGHADISTTQIYTHVLEERLHKLVSEHHPLAD
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids (By similarity).
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_CARHZ
Sequence: MDEVLNLAKKAKEASKKLAQLSTEQKNRALLKIAQYLEENMEKILTENQKDLAEAKKGGLSPAFIERLTLNEKRILDMAEGVRQVAKLPDPVGEVLGMTRRPNGLVIGQVRVPLGVVGIIYESRPNVTVDAAALCLKAGNAVILRGGKEAFNSNLALVTLMEEALRSEEIPEGAVGMIKTTSRDAANYLMRLNGYLDVLIPRGGAGLIKTVVENSTVPVIETGVGNCHVYVEEDADLEMAERIIINAKCQRPAVCNAMETLLVHEKIAPVFLPQIGKALKENGVEIRGCEVTRRYIPDALPATEEDYYTEFLDLILAVRVVRDLDEAIAHITKYGSGHSEAIVTRDYFKARRFTEEVDAAAVYVNASTRFTDGFEFGFGAEIGISTQKLHARGPMGLKELTTTKYVIYGTGQIRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPPA_ECO7I
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAARKVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVESEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIDQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: BGAL_ENT38
Sequence: MFTASPMSLSKILARRDWENPGVTQWHRLPAHAPFNSWRDEASARADDNASRKRSLNGDWQFSYYAAPEQVPDSWVTEDCADAVTTPVPSNWQMQGFDTPIYTNVTYPIPVNPPFVPAENPTGCYSLTFEVDEQWLESGQTRIVFDGVNSAFYLWCNGKWMGYSQDSRLPAEFDLSAVLRPGTNRLAVLVLRWCDGSYLEDQDMWRMSGIFRDVSLLHKPHTHIADYHAVTELNADYDRAKLQVEVALAGEQFADCEVTVTLWRDGLSVATASAKPGSAIIDERGNWAERLNVTLPVNDPALWSAETPELYRLTFALRDGQGEILDVEACDVGFRCVEISNGLLKVNGKPLLIRGVNRHEHHPENGQVMDEATMRRDIELMKQHNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMSRLADDPRWLPAMSERVTRMVLRDRNHPSIIIWSLGNESGHGANHDALYRWVKTTDPTRPVQYEGGGANTAATDIVCPMYARVDQDQPFEAVPKWSLKKWIGMPDETRPLILCEYAHAMGNSFGGFAKYWQAFRNHPRLQGGFVWDWVDQALTKKDDNGNAFWAYGGDFGDTPNDRQFCLNGLVFPDRTPHPALFEAQRAQQFFNFTLVSTSPLVIDVHSDYLFRQCDNEQLRWNIARDGEVLASGEVALTIAPQQTQRIEIDAPEFAAAAGEIWLNVDIVQTAATAWSPADHRCAWDQWQLPAPLYIAPPVEGTAKPDLKVKEDVLEVSHQSQRWHFDRASGNLTQWWNNGTATLLAPLNDNFTRAPLDNDIGVSEATRIDPNAWVERWKAAGMYNLTPRLLLCEGEQLAQAVTITTLHAWESNGKALFLSRKVWKIDRAGVLHGDVQVQVANDIPQPARIGLSCQLAQTPQTASWLGLGPDENYPDRKLAARQGRWTLPLDALHTAYIFPTDNGLRCDTRELTFDTHQLQGDFHFSLSRYSQQQLRDTSHHHLLEAEPGCWLNIDAFHMGVGGDDSWSPSVSPEFILQRREMRYAFSWRQD
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: SLMA_KLEP3
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEVQLRQVMREKKMREGEGYTLDETLLASQLLAFCEGMLSRFVRSEFKYRPTDDFEARWPLVAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NUOI_CUPNH
Sequence: MLLAIKDFFNSLLLKELFKGMALTGRYLFARKITVQFPEEKTPISPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITIESDARADGTRRTTRYDIDLTKCIFCGFCEEACPVDAIVETQILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADAKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATG1_GIBZE
Sequence: MAGPQESSTSSGSRKSGSRAVGQFNIGSEIGKGSFAQVYLGWHKETKAAVAIKSVELERLNKKLRENLYSEIQILKTLRHPHIVALHDCIESTSHINLIMEYCELGDLSLFIKKREKLATHPATHDMARKYPSMPNSGLHEVVIRHFLKQLTSALEFLRSKNYVHRDVKPQNLLLLPSQPFRDQRSRPVMQASQDSLIPISGLASLPMLKLADFGFARVLPSTSLADTLCGSPLYMAPEILRYERYDAKADLWSVGTVLYEMSTGRPPFRARNHVELLRKIEAAEDVIKFPREVSITPELKALIRSLLKRSPVERLSFENFFTHQVVTSEIPGLVEDDIPKSLRQESRDPRSAFQSGSPSLSSRSPRQTGHQSPTEALVSRSPRDQQPRSPQVGSPGGSRYARRSNESQRTTGNSPREGGEGLGIRRPVAQHAMTAPVQQVAYDSVTGRNRASPPTSLLDQVRRNRALSNPPITEEERAAQDVALEREYVVVERRHVEVNALADELAANEKLGDASQRSGPITRRYTQQGAPTSTTGAISTPYSRNALATQPRHDRKSSYEKSLSASPGSASSAISKAIQDASLRLFGFKVPPLRASPKGPSPPLYQAFPTYPTPQAPVGLLGDGRNVQGTDEDGKAAQTIEELATRSDCVYGFAEVKYKQLVPLAPSADHILGGLEPEQLVNEEDGLTVEAIVALSEEALVLYVKSLTLLARAMDIASLWWSKKSRGDTGTGLSAAAAQTVVQRINAVVQWVRQRFNEVLEKSEIVRLKLTEAQKQLPDDHPSHPSNHGTESIASSAGSPTKQVYLTPGISAEKLMYDRALEMSRAAAIDEVTNENLSGCEISYITAIRMLEAVLDNDEGSGSETRRLSTGKEAEREAVKEVSGGELDSDEEAHVRKRRLAAVRKKQQMIAEANSKTNLVYQQAVRRRSGDMTPRSVPSHASS
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes (By similarity).  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome (By similarity).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates (By similarity).  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity).  Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236).  Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: RLMH_META1
Sequence: MKLNIIAVGALTKEYKTLYEIYNKKVSFFSTINLIEIKEVTEPNIELKIKKETKLILEKIPKNSKVFYMSLTGKKMKSEEFASLLCEDNLTFIIGGSNGVEEKYFDNKICFSDLTFPHQLFRVILIEQIYRGFAINNNIKYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCME_SHEDO
Sequence: MNPRRKKRLTLAVALIVGVAGAASLLLYALNSNLNLFYTPNEIINGKNDTGIKPEIGQRIRIGGMVTMGSMVRDPDSLHVEFAVHDSTGTQVIVTYDDLLPDLFREGQGIVAQGVLTDSGKLEATEVLAKHDENYMPPEVAEAMGKQHKKLEYQEGVEKTAQY
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: GPMA_YERPB
Sequence: MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGRSEAKAAGKLLKDEGFTFDFAYTSVLKRAIHTLWNILDELDQAWLPTEKTWKLNERHYGALQGLNKSETAEKYGDEQVKQWRRGFAITPPALEKSDERFPGHDPRYAKLTDAELPTTESLALTIERVIPYWNDVIKPRIASGERVIIAAHGNSLRALVKYLDDLGEDEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: SYH_SHIFL
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGIFEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELLGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_BUCBP
Sequence: MTLLKSYFGEFGGMYVPQILMPALYKLEIEFLKALNDLQFTNELSNLLKNYAGRPTPLTLCKNITKNTNTKLYLKREDLLHGGAHKTNQVLGQALLAKKMSKKEIIAETGAGQHGVATALSCALLGLKCRIYMGFKDVIRQQQNVFRMQLMGAKVISVKNGSGTLKDACNEALRDWSENYCTSHYMIGTAAGPHPYPTMVKKFQSIIGIETRCQILKQESCLPNIIIACIGGGSNAIGIFSEFIKDKSVCLIGVEPAGKGIKTGKHGAPMQHGSTGIYFGMKAPVMQTSEGQIKESWSISAGLDFPAVGPEHAWLKHIGRATYVSITDCEAINAFKILCKLEGIIPALESSHALAYALKLISKDTNKKQIIIVNISGRGDKDIDTIRKIDVYKE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: LPXC_FRATO
Sequence: MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEAIMCTLLTKDGDQNLSVSTIEHLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQVGIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFKIHWDHPVIAATNDHIVFEYDLDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRHKLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: XNI_YERPG
Sequence: MQIHLLIVDALNLIRRIHAVQGSPCVKACQHALQQLIQHSQPSHAVAVFDEDDRSDSWRHQCLPDYKAGRSPMPDNLQQEMPLIRQAFNELGVACWHSPGNEADDLAATLVVKVAGAGHQVTIVSTDKGYCQLLAPNIQIRDYFQKRWLDMPFVKQEFGVLPRQLPDYWGLAGISSSKIPGVAGVGAKTATLLLQQADTCNERCNSDPHPTPEIRSRG
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment (By similarity).
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: HEM1_FLAPJ
Sequence: MENNTIPKHNTFYAIGLNYKKADAEIRGKFSIDAQSKSNLLQQAKTEGIESLIVTSTCNRTEIYGFAQHPFQLIKLLCENSKGTVEDFQKVAYVYKNQEAISHLFKVGTGLDSQILGDFEIISQIKIAFTESKALDLANSFMERLVNSVIQASKRIKTDTDISSGATSVSFASVQYIMKNVANIGEKNILLFGTGKIGRNTCENLVKHSKNEHITLINRTKDKAEKLAGKLNLIVKDYADLHIELQKADVLVVATGAQNPTIDKAILNLKKPLLILDLSIPKNVNSDVNELENVTLVHLDDLSQITDETLEKRKLHIPAAEAIIEEIKNEFSSWMNGRKYAPTIHALKAKLNTIKEKELIFQRKKLSNFDEEQAELISNRIIQKITNHFANHLKDEETMVDESIDYINKIFQL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: KAD_SHESA
Sequence: MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCVKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLGIYHEQTKPLVEYYGKVAAAGNTQYHKFDGTQSVAAVSAQLASVLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFOX1_DANRE
Sequence: MEEKGSKMVEQGNQDAPAPPETMAQPFPSAQFAPPQNGIPAEYTPSHPHPTPDYSGQTPVAEHTLNLYTPAQTHSEPSGPDNSIQAVSGTATQTDDSAQTDSQQQTQSSEITEIKTQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFESSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYANGWKLNPVVGAVYSPEFYAVPGFPYPAATAAAAAYRGAHLRGRGRTVYNTFRAAAPPPHIPAYGGVVYQDGFYGADIYGGYTAYRYTQPATATAAAYSDSYGRVYAADPYNHALAPAATYSVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYSRFAPY
What is the function of this protein?
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements.  Regulates alternative splicing of tissue-specific exons (By similarity).
What are the official names of this protein?
RNA binding protein fox-1 homolog 1, Ataxin-2-binding protein 1, Fox-1 homolog A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GATC_CHLPB
Sequence: MSVTIKDVAYIAELARLSFTDTEKEKMTSELNAILQYVEKLDEVDTDGVEPLSSIHDEVNVLRDDVRQESVPNETALLNAPDKLDRFFRVPKVIG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: REX_BACP2
Sequence: MNIDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVKVDSATIRRDFSYFGALGKKGYGYNVDYLLTFFRKTLDQDEMTNVMLIGVGNLGTAFLHYNFIKNNNTKISMAFDVNESKIGSEIGGVPVYDLDKLEEHVQEVGDIPVAILTVPAVAAQPITDRLIALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSITQED
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI72_HUMAN
Sequence: MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA
What is the function of this protein?
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites.  Specifically binds phosphatidylserine.  Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site.  This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation.  Probably acts upstream of the Ca(2+)-dependent membrane resealing process.  Required for transport of DYSF to sites of cell injury during repair patch formation.  Regulates membrane budding and exocytosis.  May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
What are the official names of this protein?
Tripartite motif-containing protein 72, Mitsugumin-53, Mg53.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.