PharMolix/UniProtQA huggingface dataset:
Protein: RL22_HELPJ
Sequence: MSKALLKFVRLSPTKARLIARQIQGMNAELAIASLEFTPNKAARVLSKVVASAVANGSLDAKSALIVSCRVDAGPVLRRSIPRAKGRATAIRKPTSHVFVEVAEGKEMKSSKSHKKNQAEGK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SYE_UREP2
Sequence: MKIRTRYAPSPTGYLHIGGARTALFNYLLAKAYGGDFIIRIEDTDIERNVEGGINSQLDFLAWMGIIPDESIRNPKAFGPYIQSEKLKHYEKLALDLVDQKKAYFCFCSKEQLDADRELAEKSHQTPKYKRHCLNLDKKTIESNLLQNKEYTIRLKINENMEYSWDDLIRGKISIPGSALTDPVILKSNKIAMYNFAVVIDDYEMQISHVIRGEEHISNTPYQLAIAQALNYDITKIKYGHLSIIVDETGKKLSKRNLSLKQFVSDYEKDGYWPHAITNFVALLGWSPKNNDEIMSLETMIKNFDINNLSKSPAFFDINKMNWFSTQYFNNITQEEFINFIKKHSLTKELVLNDYTFINKCLLFKSHIINLKQLIDLVIEQFNCDKKVLASDVDYIKKNQLITVVRVFYEQLIINDEFNEEFIKEIIKKVQIITNNKGANLYMPIRIATTFSSHGPELAKTICYLGREKVLKNLINILKILD
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OST1A_ARATH
Sequence: MKQSSVVDLLLLLLAIALLATPAFSDLVLSKVERRIDVTSQIARVTKTLKVVNSGSESVSEFALTFPKFLGNNLAYLSVAPSEGKGKSKRTLVNLSVREADQKGLPDSISVYSVALPKPLSKGDTLTLEVVAAFTNVLQPFPEKITQGEIHLVMLQESAQYLSPYAVESQSLSIKLPNARIESYTKFENTKLQGSELKYGPYKNLQSYSYSPIVVHFESKAAFAVAEKLVREIEVSHWGNVQVTENYNVVHRGAQLKGEFSRLDFQARPNPRGASAFRHLLARLPPRAHSIYYRDDIGNISTSEMKSDSKKTELLIEPRFPLFGGWKTFFTIGYGLPLTDFLFASEGKRFLNISFGSPILDLVTEKLIVQVVLPEGSKDISVTTPFAVKQSQEIKYSHLDIAGRPVVVLEKNNVVPDHNQHIQVYYKFSNINLLSEPLMLISGFFILFITCIIYTRADISISKSSPSYLAKLQWDEVLATLQEVQSIVQKCLATHDKLEASLRDLSRTGDIQTCKAARKSTDSLLKDLSKELKPLLGFLQSFPSASHISPKVEELVVKEKELQEKLMAKHTTVVEGYEKKSSGRDIENRIASQQQKIIALRQEIEDLLEFIDEI
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A, Ribophorin IA, RPN-IA, Ribophorin-1A.
What is the protein family that this protein belongs to?
Belongs to the OST1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: GRK7B_DANRE
Sequence: MSDMGGLKNLVANTDYLKAQSLDEKEIKKRRCSLGLPHLGNCTDVRVSVSKGFEDICEQQPIGRACFRQFLSVSSPEYLAAAELLDELNCWNLAEAEAKEEARLNIINKFCKADSKSFLAFLTEDEAEKCKAVSEKDFEEVMMGQVKEATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQVKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGGDLKYHIFHVGEVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLAVELPNGKTTTQKAGTKGYMAPEILKQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELLRRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLGSNDDPRKHEFFKSINFPRLEAGLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGVVPIAWQQEMIDSGLFDELSDPNRKESAAGLEDEEQQKSKSCTLL
What is the function of this protein?
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
What are the official names of this protein?
Rhodopsin kinase grk7-b, G protein-coupled receptor kinase 7-2, G protein-coupled receptor kinase 7B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: VPS72_BOVIN
Sequence: MSLAGGRAPRKTAGNRLSGLLEKEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKTREEKALLPLELQDDGTDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPMASALAARAGTGPVIPPARCSRTFITFSDDATFEEWFPQGRTPKIPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
What is the function of this protein?
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes.  As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 72 homolog, Transcription factor-like 1.
What is the protein family that this protein belongs to?
Belongs to the VPS72/YL1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MINE_CLOBB
Sequence: MGFFKGLSSRPTPKQVAKDRLKLILIHDRGEIPTDTLEKIRKEILGVISKYIEIQVDDVEISVNKSEDMEGENTSALIASIPIKSIRR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RS8_BEII9
Sequence: MAVNDPLGDMLTRIRNAQMRRKGKVQTPGSRLRAHVLDVLQEEGYIRGYSTTEYGNGRSEFEIELKYFDGLPVIREIQRVSKPGRRVYTAVNAIPRVANGLGISIISTPKGVMADHAAREANVGGEVLCKVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ADE_PSEF5
Sequence: MYDWLNALPKAELHLHLEGSLEPELLFALAERNKIALPWSDVETLRKAYAFNNLQEFLDLYYQGADVLRTSQDFYDLTWAYLLRCKEQNVIHTEPFFDPQTHTDRGVPFEVVLNGIASALKDGEQQLGITSGLILSFLRHLSEEEAQKTLDQALPFRDAFVAVGLDSSEMGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKIQRIDHGVRAFEDERLMQRIIDEQIPLTVCPLSNTKLCVFDHMSQHNILQMLERGVKVTVNSDDPAYFGGYVTENFHALHTDLGMTQDQARRLAQNSLDARLVKP
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: GLGA_DESHD
Sequence: MKVLFAITEAEPFVKTGGLGEVGRYLPLALQEQGVEIRVILPQYSSIPRNYLQKMKTIKEFTVPLAWRNQYCGLKELKYEGIHYYFLDNEYYFRRSRCYGDGDEGEQYAYFSRAVLESVRYLPEFKPDIIHCHDWHTALVPLFLKAFYAQDTLYYNIKTLFTIHNLKYQGIFPREVREDVLGLSGELSSSAQLEFYGGVNFMKAGIMHSDQVTTVSPTYAREIQHPYFGEGLHGVIQGRKDSLLGILNGVPRPWPSPTLADKRANRMKLQEQLNFTNNEEIPILSMISRLVEQKGLDLLLHVLDEILALDIRLVVLGTGDAHYEERLQRFAEGYPGKLRVILGYQEELAHRIYAGADIFLMPSRFEPCGIAQMIAMSYGTIPIVRETGGLKDTVRPYSPISGEGNGFTFTDYNAHELLYAIQKAVEMFRNQKDTWQKLQENALSSDFSWNRSAARYRDVYESLYYSS
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: C16AA_PARBF
Sequence: MNTNIFSTHLEFSKGVASVFKVIDTIHNISKNNNFNNILTQDFIIDTILSILWEDPNENEIFSSMIEDGETITNKNLSAQTKEGLLLNSNSFGLKFKYYNNAFRSWIDNYNPTSIDDVVYRFKDVNSICENNINEFKVKNYEVTVLPIYMQIANLHLLLLRDGMIYGDAWNLYRELGFSDQDSFYNHVLDKTKFYINDCLNYYNTGLSNLKLDPNNSWIDITRYCRFMTFYILDMISICPIYDTKVYDKPINMQTLTRKVYSDPVNFIDENIPISEYEKMYNISPELFSTLFSISFYTNKSGNKFLNGHVNRHVGTDLNYNGLRETHYGNYGSNYEVESMAFDDIKAYSNNYFNNTQNNNPTSVKSIKFLITKNNDEWIYGEPDSSNIDFTRNIQGYLSNLNNESYTHSLSDMILANNDKIQINIDTPHSYSYSWIYKGIEDTNYISDKLINQIPLVKEVKLKSRHYSEISVIKGPGFTGGDLILSKVHKPANQIPAQYMKNKITIPIKTKFPAGSQDFKVRLCYASNHDIGLIRLIAGSKYITTNIQQTFNTTENNPSLIYDDFKYFNFNETLSITSSGIDELYLEFYYSYTDGNFEDFPKLSIPYTRNYSC
What is the function of this protein?
Toxin active on mosquito larvae of the species Aedes aegypti, Culex pipiens and Anopheles stephensi.
What are the official names of this protein?
Pesticidal crystal-like protein Cry16Aa, Cbm71 mosquitocidal toxin, Insecticidal toxin CryXVIA(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPPP1_ACIAD
Sequence: MDLLLLLKAAIMGIVEGITEFLPISSTGHLILASELMNFWTKEKSAVFVVAIQMGAIAAVIYEYWSRLWGAATGMVTGEEKGRHLAISLILASIPIVLVGLSFGQTVKDLLFNDVAVAIGLIVGGVIIMWIEKNPPKVNAVEVENIGLKQAIWIGLIQVLSLIPGTSRSGATIIGAMFLGVSRKAATEFSFFLGIPVIIGAGLLDLYQSHEVLQTSFDWSVLGVGILVSFVSALLLIRALVAYVAKRDFMVFAWYRIVSGLLILLFAYTGWTIW
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCNA_POPNI
Sequence: MLELRLVQGSLLKKVLESIKDLVNDANFDFSSSGFSLQSMDSSHVALVALLLKSEGFEHYRCDRNTSMGMNLGNMSKMLKCAGNDDIITIKGDDGSDTVTFMFESPTQDKIADFEMKLMDIDSEHLGIPEAEYHAIVKMPSAEFARICKDLASIGDTVVISVTKEGVKFSTRGDIGTANIVLRQNTTVDKPEDATVIEMNEPVSMTFALRYMNSFTKATPLSNTVTISMSPDLPVVVEYKIAEMGYVRFYLAPKMEEDEPEPGA
What is the function of this protein?
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
What are the official names of this protein?
Proliferating cell nuclear antigen, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HNRPD_MOUSE
Sequence: MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAAAAQGPAAAAGSGSGGGGSAAGGTEGGSAEAEGAKIDASKNEEDEGHSNSSPRHTEAAAAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
What is the function of this protein?
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs.  Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor.  Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat.  Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.  Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation.  May be involved in translationally coupled mRNA turnover.  Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.  May play a role in the regulation of the rhythmic expression of circadian clock core genes.  Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation.  May also be involved in the regulation of PER2 translation.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein D0, hnRNP D0, AU-rich element RNA-binding protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
Protein: PRCMA_TRYCC
Sequence: MRKSVCPKQKFFFSAFPFFFFFCVFPLISRTGQEKLLFDQKYKIIKGEKKEKKKNQRANRREHQQKREIMRFKKSFTCIDMHTEGEAARIVTSGLPHIPGSNMAEKKAYLQENMDYLRRGIMLEPRGHDDMFGAFLFDPIEEGADLGMVFMDTGGYLNMCGHNSIAAVTAAVETGIVSVPAKATNVPVVLDTPAGLVRGTAHLQSGTESEVSNASIINVPSFLYQQDVVVVLPKPYGEVRVDIAFGGNFFAIVPAEQLGIDISVQNLSRLQEAGELLRTEINRSVKVQHPQLPHINTVDCVEIYGPPTNPEANYKNVVIFGNRQADRSPCGTGTSAKMATLYAKGQLRIGETFVYESILGSLFQGRVLGEERIPGVKVPVTKDAEEGMLVVTAEITGKAFIMGFNTMLFDPTDPFKNGFTLKQ
What is the function of this protein?
Catalyzes the interconversion of L- and D-proline.  Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen.  Probably involved in parasite differentiation and infectivity.
What are the official names of this protein?
Proline racemase A, TcPA45-A, TcPRACA, rTcPA45.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. Membrane. Note=Membrane-bound and secreted upon differentiation of the parasite into non-dividing infective forms, suggesting that isoform 1 appears upon differentiation (PubMed:16164548). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Cytoplasmic in replicative non-infective forms (PubMed:16164548).
Protein: RF3_MACCJ
Sequence: MTLREEVEIRKTFAIISHPDAGKTTLTEKLLLFGGAIREAGTVKGKKTGKFATSDWMEVEKQRGISVTSSVMQFDYDNFKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLEEIEKTLEIETYPMNWPIGMGQSFFGIIDRKTKTIEPFRDEENVLHLNEDYELQESHAITSDSAYEQAIEELMLVDEAGETFDKEKLMTGDLTPVFFGSALANFGVQNFLNAYVDHAPMPSGRKTESGEEISPFDESFSGFIFKIQANMNPQHRDRIAFMRIVSGAFERGMDIKMTRTDKKMKISRSTSFMADDTQTVNHAVSGDIIGLYDSGNFQIGDTLVGGNQKFQFEKLPQFTPEIFMKVSPKNVMKQKHFHKGIEQLVQEGAIQLYRTLHTNQIILGAVGQLQFEVFEHRMNNEYNVDVIMEPVGRKIARWIENEADIRDAMNSSRSILVEDRFENKVFLFENEFATRWFLDKFPEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSPK_GEOTN
Sequence: MRNKEHNFPNQNNNKFEGEPRAKSEYASKRADGTTNTHPQERMRASGERSDFF
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: PRHJ_PENBI
Sequence: MAIGPKPESIIGSCDHPPQAEAQTGARLAAINGNNSPVSRLKDFTTDPWLTSTDQPQPGSTTNVPYSPPDSTKHARILIVGAGYGGLLFAVRLLQSGFTLEDILLVDSAGGFGGTWYWNRYPGLMCDIESYIYMPLLEETKNIPSQKYVSGEELRTHAERIAEKWKLGARTLFRTTVSDLTWDDNKLQWIATASCSSNERKQAGCTYTINADFAILANGTLSKPKVPDLPGIDDYTGRIFHTARWDYDYTGGSPAIPAMDQLRTKKVGVIGTGSTAVQVIPQLARWAGELTVFQRTPGAVGLQINRETDHAWWRDNVQLAGPEWQRKRCENFNAFITNPYRASLDAEDLVKDGWTKHPSFSVALGGARNLQADFLDLAKKIDKERREIGQQHINSTVRDPATAEALFNPTYGWCKRPCFHQGYFETYNRENVRLVSTPGQGITKLTRNGIMWGHQEFELDLIVLATGYELGSLCPANRARLSIHGRGRVSMSQKWASGPATLHGVMTRGFPNLFFPGTSQAGVTANQSYMFDRAAEHIAYIIQNARPRTAASAVNPKVRIEPSLEAEELWAMETVSRAKAFAATKTCSAGSYTISARLGESVDESQMARHMPWGEGMASYVKILEEWRKKRDMHGLEVVYD
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
FAD-binding monooxygenase prhJ, Paraherquonin biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: AP2M1_CHICK
Sequence: MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMTAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETGKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
What is the function of this protein?
Component of the adaptor complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.  AP50 is a subunit of the plasma membrane adaptor.  The complex binds polyphosphoinositide-containing lipids.
What are the official names of this protein?
AP-2 complex subunit mu, AP-2 mu chain, Clathrin assembly protein complex 2 mu medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP50, HA2 50 kDa subunit, Mu2-adaptin, Plasma membrane adaptor AP-2 50 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Protein: KPRS1_STRA5
Sequence: MSYSNLKLFALSSNKELAKKVSQTIGIPLGQSTVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAESVSVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRQGLVGDDVVVVSPDHGGVTRARKLAQCLKTPIAIIDKRRSVTKMNTSEVMNIIGNIKGKKCILIDDMIDTAGTICHAADALAEAGATAVYASCTHPVLSGPALDNIQNSAIEKLIVLDTIYLPEERLIDKIEQISIAELIGEAIIRIHEKRPLSPLFEMNKLK
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 1, RPPK 1, 5-phospho-D-ribosyl alpha-1-diphosphate synthase 1, Phosphoribosyl diphosphate synthase 1, Phosphoribosyl pyrophosphate synthase 1, P-Rib-PP synthase 1, PRPP synthase 1, PRPPase 1.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_BRASO
Sequence: MSKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALKDDGYDYIGGLEMGAVPLAGAIAQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLAGKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDREEGAAEAFAAAGLSFRALYKAREFL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PLSY_ECO7I
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECA_XANCP
Sequence: MDENKKRALSAALSQIEKQFGKGSVMRMGDRVIEAVEVIPTGSLMLDIALGIGGLPKGRVVEIYGPESSGKTTLTLQAIAECQKLGGTAAFIDAEHALDPIYAAKLGVNVDDLLLSQPDTGEQALEIADMLVRSSSVDIVVIDSVAALTPKAEIEGEMGDQLPGLQARLMSQALRKLTGNIKRSNTLVVFINQLRMKIGVMMPGQSPEVTTGGNALKFYASVRLDIRRIGAIKKGDEIIGNQTKIKVVKNKLAPPFKQVITEILYGEGISREGELIDMGVEAKLVDKAGAWYSYGDERIGQGKDNARGYLRDNPQVAIKLEAELREKFQPAEAPREAGETESE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.