PharMolix/UniProtQA huggingface dataset:
Protein: ERGI3_DICDI
Sequence: MLISQLKKFDAYPKTVDDFRVKTYTGAIVSIIGGVFILWLFFSQVTLYFSTDIHHELFVDTTRGEKLKINMDITFHHLPCAYLSLDAMDVSGEHQFDVAHNIFKKRLSPTGQPIIEAPPIREEEINKKESVKDNNDVVGCGSCYGAEDPSKGIGCCNTCEEVRVAYSKKGWGLDPSGIPQCIREGFTKNLVEQNGEGCQVYGFILVNKVAGNFHFAPGKSFQQHHMHVHDLQPFKDGSFNVSHTINRLSFGNDFPGIKNPLDDVTKTEMVGVGMFQYFVKVVPTIYEGLNGNRIATNQYSVTEHYRLLAKKGEEPSGLPGLFFMYDLSPIMMKVSERGKSFASFLTNVCAIIGGVFTVFGIFDSFIYYSTKNLQKKIDLGKTF
What is the function of this protein?
Possible role in transport between endoplasmic reticulum and Golgi.
What are the official names of this protein?
Probable endoplasmic reticulum-Golgi intermediate compartment protein 3.
What is the protein family that this protein belongs to?
Belongs to the ERGIC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.
Protein: PABP5_GORGO
Sequence: MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETINDEKLKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVTLGQARRRC
What is the function of this protein?
Binds the poly(A) tail of mRNA.  May be involved in cytoplasmic regulatory processes of mRNA metabolism.  Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein 5, PABP-5, Poly(A)-binding protein 5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_LACDB
Sequence: MNDYLIKAINASKDLRLLTINGKDLVAEAQKRHDTWSASSAVLGRSLLGTLLLAGAELKGDQELTLRLLGDGPVGAAVVTAKSDLTVKGYVQNNHVALPAREDGHIDVKKAVGKGWLQVTKDLGLKQPYTGEVPIVSGEIAEDLTYYLAKSEQIPSAVGLSVFVNPNDTIGAAGGFLLQALPGASEELLQETEDRIKALPQLSSAFLDGMTPEDLAKKILGDDSKILEKDEVSYHCDCSKEKYAGMLETLKGSQLKEMIDEDHGAELVCNFCGNKYNFTEAELQAILDKKLGK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBID_BORPD
Sequence: MKYRDLRDFLQQLELRGELKRIATPVSTHLEMTEIADRVLRAQGPALLFEHAVHNGARAAMPVLANLFGTPRRVAWGMGADEVSALRDTGELLASLREPEAPRGLRDALGKVAMLKSALWDMAPKRVRGPACQEIVWEGADVDLARLPIQTCWPGDVAPLLTWGLVITRGPNARRQNLGIYRQQPIAPNKLIMRWLSHRGGALDFREHARAHPGTPFPVAVALGADPATILGAVTPVPDSLSEYQFAGLLRGSRTEVGQALGSDLSVPAWAEIVLEGHLLPANDPRAVAPVVPEGAPPPPDTGYEMALEGPYGDHTGYYNEQDWFPVFTVDRITMRRDPVYHSTYTGKPPDEPAVLGVALNEVFVPLLRRQLPEIVDFYLPPEGCSYRLAVVSIRKQYAGHAKRVMFGLWSVLRQFMYTKFIVVVDDDIDPRNWNEVVWAITTRMDPVRDTVLVERTPIDYLDFASPVSGLGGKMGMDATNKWPGETDREWGRPIAMDDAVKQRVDAMWGELGL
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DHAS2_VIBCH
Sequence: MSQQFNVAIFGATGAVGETMLEVLQEREFPVDELFLLASERSEGKTYRFNGKTVRVQNVEEFDWSQVHIALFSAGGELSAKWAPIAAEAGVVVIDNTSHFRYDYDIPLVVPEVNPEAIAEFRNRNIIANPNCSTIQMLVALKPIYDAVGIERINVTTYQSVSGAGKAGIDELAGQTAKLLNGYPAETNTFSQQIAFNCIPQIDQFMDNGYTKEEMKMVWETQKIFNDPSIMVNPTCVRVPVFYGHAEAVHVETRAPIDAEQVMDMLEQTDGIELFRGADFPTQVRDAGGKDHVLVGRVRNDISHHSGINLWVVADNVRKGAATNAVQIAELLVRDYF
What is the function of this protein?
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
What are the official names of this protein?
Aspartate-semialdehyde dehydrogenase 2, ASA dehydrogenase 2, ASADH 2, Aspartate-beta-semialdehyde dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: ACPS_ECOUT
Sequence: MAILGLGTDIVEIARIEAVIARSGERLARRVLSDNEWEIWKTHHQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALKLAEKLGVVNMHVTLADERHYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_METI4
Sequence: MVQDIKRAEIALDFKNKPVFFLVGSTGIGKTAIAHRIADEIGLSLLSIDSMQVYRKLDIGTAKPSLSERIRYRYGGIDLVDWKDSFNAFLFVQQACHYLAKEWENRRGVLAVGGCGLYFRAMTRGLCNAPPANLQLRTELEKMDRITLLERLTRIDPSAVAWVDCSNPRRIIRAIEVKETSGISLIEWQKKTTLPLVTPFLAFWIDRPQPEAEIRLRRRIKKMFERGWEEETLMLIEEGGMEAVEKCKAIGYKLIGQFLLQKRKNREELEEAIYRQQHGYAKRQKTWFKKEPSLCYYLLKNPEEEYRFIKSCIEKIAFFIRRNHQDFLY
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: THIC_XANC8
Sequence: MNAAPTVLLQQTQTLSAAVTQPIPGSRKIFVQGSRADLQVPMREIVLTRTPTLFGGQDNPPLSVYDTSGPYTDPQAAIDLAAGLAPLRADWIAERGDTLPLEALSSSFGRGREHDARLDAVRFPSRRLPRVARSGANVTQMHYARRGIITPEMEFVAIRENQRLEAVTDAVLRKQHPGEAFGAAIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETRDWIIRNSPVPIGTVPIYQALEKVDGRAEELTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTARRVTGIVSRGGSILAKWCLAHHKENFLYTHFEDICEIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGVQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYAAEHGISEDHALEAGMQEKSGEFVAQGAQVYRAS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: VE2_HPV40
Sequence: MENLARRLDLCQEQLLELYEQNSKELQQHILHWKYIRYESAIYYTARQMGIKHLGHQVVPSLDVSKAKAHAAIEMQMCLESLQNTEYNVEPWTLQDTSQELWLAEPKKCFKKGGKTVEVRFDCNETNAMHYTLWTTVYVQVDDAWTKVKGQVDYKGLSYTVHGCTTYYVDFAKEAQTYGKTNRWTVIVGSHVICSPSTIEEHGLPIVETADARPPTTATDTPDAPATATTETVGPAQAPPRKRRRNGHLPITTTVGKSLGGEYVDTADRTRTPDPESNNGHRNCGGGSSTPIIQLEGEANCLKCFRYRLGKVSHLFCNSSTTWRWTTESRTEKNAIITLTYSSVQQRSDFLAIVKIPKTIKHSLGMLTLM
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RSRC2_HUMAN
Sequence: MAASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV
What are the official names of this protein?
Arginine/serine-rich coiled-coil protein 2.
What is the protein family that this protein belongs to?
Belongs to the RSRC2 family.
Protein: MDV1_YEAST
Sequence: MSVNDQITHIGKTLSTTASAFLNYQKSNSNTQDVLTNNGPYKNLLSNTVNNASSTSYFYKRTEHGRFVKNASNTFEDIYSKTRRGDVFRNKFTDNKTCFRMLTYISDDLLNEIPTKEGLKSDADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNYDTNGTSGTVGAKDVMSKTNERDEIHTELPNFQDSFLIPPGVETKKISSSYSPSALKSFSQTLVNSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEEYGLEVIEANSDENAEDDGMSERKALKNDAIRNEGVTTESISSEASNLPPRRRQQLRDDNSLNRLGAFYSKSKKRHRKSFPTFQQLYEPGTKIGSIMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVHTFEAHTDEVTALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTTSTNVDLSKSTLLTQRNERPSIGALQSFDAALATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKFDSACLVTGSYDRTVRIWDLRTGLLNKFHAYSAPVLSLDLFQENAAVVVADEPSVQIYDSEKDESWSCVEQGNETSVSTVKYKENYMVEGRENGDVNIWAV
What is the function of this protein?
Involved in mitochondrial fission.  Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes.  Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
What are the official names of this protein?
Mitochondrial division protein 1, Mitochondria fission 2 protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MDV1/CAF4 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localization is dependent on FIS1. Reorganizes to punctate structures on mitochondria, corresponding to mitochondrial constriction sites, at a late step in mitochondrial division. This relocalization is dependent on DNM1.
Protein: RNC_CHLFF
Sequence: MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVTEHLFLLFPSMDEGTLSTARAALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYANLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGNPKNRLQQLTQKQLRTLPVYQSTPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_XANCB
Sequence: MSEWLFDLGNSRFKYAPLDGTRAGDVQAWAHGAEAMDTAALSALPSGKVAHVASVAAAGLTERVLASLRTRFEQVRVVRTAAACAGVRIAYADPSRFGVDRFLALLGARGDAPVLVAGVGTALTIDVLDADGQHHGGRIAASPTTMREALHARAVQLPPTGGAYAELANDTDDALTSGCDGAAVALIERSLQHAARTLGMPVRLLVHGGGAPPLLPLLPTAEFRAALVLDGLATWATHSAAP
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPWD1_PONAB
Sequence: MAAESGSDFQQRRRRRRDPEEPEKTELSERELAVAVAVSQENDEENEERWVGPLPVEATLAKKRKVLEFERVYLDNLPSASMYERSYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIECIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSICFSPDGKKIATIGSDRKVRISKFLTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADPTVVCTPFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIINITVK
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  May be involved in pre-mRNA splicing.
What are the official names of this protein?
Peptidylprolyl isomerase domain and WD repeat-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with spliceosomal complexes.
Protein: RIPK3_HUMAN
Sequence: MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
What is the function of this protein?
(Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion.
What are the official names of this protein?
Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection.
Protein: GLYA_HAEIN
Sequence: MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLILSSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKGALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYPK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_ACICJ
Sequence: MASTLFDKIWAAHVVDRMPDGTAVLYIDRHLVHEVTSPQAFEGLRMAGRKVRRVDATIAVADHNVPTEDRAAGIAEPESALQVATLEQNVAAFGVPYIPVTDARQGIVHVIGPEQGISLPGMTIVCGDSHTSTHGAMGALAFGIGTSEVEHVLATQTLLQKPAKNMLVRVDGTLPPGCSAKDIVLAIIGEIGTAGGTGHVIEYAGEAIRALDMAGRMTVCNMSIEAGARAGLIAPDETTFEYVRGRPYAPKGEALERAIDYWKTLASDEGAQYDRVVTIDASALVPQVTWGTSPETVVPITGHVPDPAAEPDAGRRAQMERMLQYMDLAPGQALKGTKIDAVFIGSCTNSRIEDLRVAAGIVRGKKVAGHVRAMVVPGSGLVKAQAEAEGLAQVFLDAGFEWREAGCSMCLGMNPDKLKPGERCASTSNRNFEGRQGPGGRTHLVSPAMAAASAITGALADPREMA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RRF_STRP2
Sequence: MANVIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEYYGVETPLNQIASITIPEARVLLVTPFDKSSLKDIDRALNASDLGITPANDGSVIRLVIPALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKQEKAKEITEDELKTLEKDIQKVTDDAVKHIDDMTANKEKELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_LATSS
Sequence: MNIKIITVGKLKEKYLKAGIAEYAKRLSKFCKFEIIEVSDEKAPESLSEAEMTTVKDKEGERILAKVKDKEHVIVLAIHGKQRASEEFAKEIQDLATYGTSDITFIIGGSLGTSDAVNKRANDALSFGKLTLPHQLMRLVLTEQIYRAFMINQGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_STACT
Sequence: MKCPKCNSTHSRVVDSRHADEANAIRRRRECENCGTRFTTFEHIEMSPLIVVKKDGTREQFLREKILNGLVRSCEKRPVGYQQLEDITNKVEWRLRDEGQAEVSSREIGKHVMNLLMHVDQVSYVRFASVYKEFKDVDQLLESMQGILQEKNKRSDN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CSF1_RAT
Sequence: MTARGAAGRCPSSTWMGSRLLLVCLLVSRSVAEVSEHCSHMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLNSCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCNDSFAKCSSRDVVTKPDCNCLYPKATPSSDLASASPHQPPAPSMAPLADLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHEDPQPHPSAGAPIPGVEDIIESSMGTNWVLEEASGEASEGFLTQERKFSPSNPVGGSIQAETDRPWARSASSPFPKLTEDQQPTNITDTPLTEVNPMRPTGQTLNNTPEKTDGSSTLREDQQEPRSPHFATLNPQRVGNSATPYAKLLPPKSHSWGIVLPLGELEGKKSTRDRRSPAELKGGPASEGAARPVAQSTRDRRSPAELKGGPASEGAARPVARFNSIPLTDTGSSIQDPQTSAFVFWVLGIILVLLAVGGLLFYSWKRRSHRDPRTLDSSVGRPEGSSLAQDEDRQVELPV
What is the function of this protein?
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.  Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes.  Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development.  Required for normal male and female fertility.  Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration.  Plays a role in lipoprotein clearance (By similarity).
What are the official names of this protein?
Macrophage colony-stimulating factor 1, CSF-1, MCSF, Proteoglycan macrophage colony-stimulating factor, PG-M-CSF.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
Protein: GREA_MARSD
Sequence: MSTIPISKEGFAKIKAELASLKKERPEVIKAIAEAREEGDLKENGGYHAARERQGMLEAKINYIESRIPQFNVVDMTTLGGEKITFGATVTLEDIDTGAEKTYTIMGPDESDFKKGIISIESPVGKALLGKIEGDEVVVNAPKGKIEYGIVSVIFNGPIS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: MTNA_AEDAE
Sequence: MSLKAIKYSNGKLEILDQLLLPAQSKYIDVKGVEDGWKAINKMQVRGAPAIAIVGCLSLAVEIFGEKFDTKQTFKQEVEGKLNYLVSARPTAVNMKLAAEDLISLANALAQDESISVDTMKERFLKAIEDMLDKDIADNMAIGKNGADIILSHIPNGGSVRILTHCNTGSLATAGYGTALGVIRKLHEMNRLEHVYCTETRPYNQGARLTAYELVHDKLPATLILDNMVASLFKSRRVAAVVVGADRVAANGDTANKIGTYQIGVVAKYHDVPFYVAAPFTSIDLKIPSGDRIVIEERPDREMTHVGEHRIAAPGIACWNPAFDVTTADLITGIITEKGVFKPAELKEKVEQIISTNQKL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ODO1_BACAA
Sequence: MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFEIFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAANGQSLLEKAMNELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKEVYTQSLAYEFSHIQDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGVDMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAVANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSGLPEQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSYDSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRMLFKKDFLIDLIGYRRYGHNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEIETITQFTQEQLKSDYAQVPPADTSDATIHVKVPDVVAKGIQPIDTGVELDSLRAINEGLLSWPEGFNVYPKVKKILERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTNETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQALFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSAAQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTANQLSEGRFQPALEQENLGTKPNKVKRLVLSTGKMAIDLAAEIESGRHEYNLDEIHIVRIEQLYPFPAEKVQSIIKRFKNLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQELIVSHALDVKYNFRQDKLEIEVFSN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.