PharMolix/UniProtQA huggingface dataset:
Protein: RSXC_ECODH
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGRGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWADYRTRSREELIERIHQFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSNDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSANELGEPQEEQSCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAELQQTNDAATVADPRKTAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKREQQPANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAVPEEQVDPRKAAVAAAIARAQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GPMA_MYCUA
Sequence: MGDTGTLVLLRHGESDWNARNLFTGWVDVGLTEKGRAEAVRSGELLAEQDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKAETKARYGEEQFMAWRRSYDTPPPLIEKGSEFSQDADPRYANIDGGPLTECLADVVARFLPYFTDVIVGDLRAGKTVLIVAHGNSLRALVKHLDQMSDEDIVGLNIPTGIPLRYDLDERLQPVVPGGTYLDPEAAAAGAAAVASQGAAKA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RL28_COXBR
Sequence: MAKVCQVTGKRPQSGNNVSHANKKTNRRFLPNLKKRRFWLPDEKRFITLTVSTHGMRIIDKLGINAVLKKIREREKESK
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PSTB_CUPMC
Sequence: MTSTVIDIPDTVRAKIDVRNLNFYYNQFHALKNINMSIPDRKVTAFIGPSGCGKSTLLRTFNKMYALYPEQRAEGEISMDGENLLTSKQDISLLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRSEMDDRVEWALSKAALWNEAKDKLHQSGYGLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELIAELKDEYTVVIVTHNMQQAARCSDYTAYMYLGELIEFGETEKIFIKPHRKETEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MINY2_HUMAN
Sequence: MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAARRSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEETAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL
What is the function of this protein?
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798).  Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312).  May play a regulatory role at the level of protein turnover (PubMed:27292798).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-2, Deubiquitinating enzyme MINDY-2, Protein FAM63B.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
Protein: DHE4_TUBBO
Sequence: MSNLAPEPEFQQAYNELVHSLRDQNSSRLPQILRLLCLSSPPERVIQFRVTWEDDKGNFQVNRGYRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQTFKNALTGLNMGGGKGGSDFDPKGKSDNEIRRFCYSFMRELSKHIGQFTDVPAGDIGVGGREIGYLFGAYESYKNQFEGVLTGKGITWGGSLIRPEATGYGLVYYVAHMISYASGGKETFAGKRVAISGSGNVAQYAALKVLELGGKVITLSDSKGALIATGEEGFNETDIELIAKLKLDRGYLTQLHAAEDSFKSRFKYLPGERPWCHVDKVDVALPSATQNEVSEQEAKELIASGCKFLAEGSNMGSTQEAINVYEEDRKSRKADGLWYGPAKAANCGGVAVSGLEMAQNSQRLTWTSEQVDKELAGIMERCFWNCLNPAKEYFDIAEGELPSLVAGANIAGYVKVVNAMKAQGDWW
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH, NADP-dependent glutamate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: TRMD_RICBR
Sequence: MSRLHATILTVFPEMFPGTLGHSLAGQALQKNIWSYDVINIRDFGLTKHKNVDDEAYGGGDGLIMRPDVLGNAIDHALSLNPRAKIYYPSPRGKVFTQGFAKEILRDIQLNSESFRQDEFKEEPAEHIIIREQRRMPQNSLVSSLLNDAVNMIFLCGRYEGIDERVIEEYNITEISVGDYILSGGEIPTLTILDCLIRLLPGVLMNQNTLASESFEKDGEFEGGLECGLYTRPEVWYNRKVPSVLLSGNHKLINEWKKEQSLMITKLRRPELLKDLRDKERS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHBA_NEIME
Sequence: MFERSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVAEKETEVKEDAPQAGSQGQGAPSTQGSQDMAAVSAENTGNGGAATTDKPKNEDEGPQNDMLQNSAESANQTGNNQPADSSDSAPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDSCNGDNLLDEEAPSKSEFENLNESERIEKYKKDGKSDKFTNLVATAVQANGTNKYVIIYKDKSASSSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPAKGEMLAGTAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD
What is the function of this protein?
May play a role in extracellular-DNA (eDNA) mediated biofilm formation.  When NHBA is not processed by NalP there is an increase in biofilm formation (PubMed:23163582).  Lack of processing may lead to an increase in positively charged, NHBA- and IgA-derived DNA-binding peptides on the cell surface, resulting in increased DNA-binding peptides and increased biofilm formation (Probable).
What are the official names of this protein?
Neisserial heparin binding antigen, NHBA, Genome-derived Neisseria antigen 2132, GNA2132.
What is the protein family that this protein belongs to?
Belongs to the NHBA family.
Protein: HRCA_CAUVC
Sequence: MTQLFPGPIVRTPGLAELDARARDIFRRVVESYLETGEPVGSRTISKGGVALSPASIRNTMQDLAQLGLLDAPHTSAGRMPTHAGLRMFVDGFLEVGDVAEQEKRAIEARLAVKGRSFEEALAEASSILSGLAGGAGIVVTPVREGGVKHVEFVPLGGGQVLAVMVFEDGQVENRLMRQAPGVTPSALQEASNFLNARLRGRTLTEARTEMGGELDAARRQLNETAARLVEDGLAAWSGGEGDARSLIVRGQANLLADARAREDIDRVRQLFDDLSRRAQLIGLLDDVRDAEGVRIYIGAETRLFSLSGSSVIAAPYMTGRQKVLGAIGVIGPARLNYARVIPLVDYTARVLGRMMDG
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PRP28_YEAST
Sequence: MARPIDVSQLIAGINKKKGLDENTSGKISKPRFLNKQERSKQERLKENEESLTPTQSDSAKVEIKKVNSRDDSFFNETNDKKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTRAIDLLWKGKTPKNAAESSYMGKHWTEKSLHEMNERDWRILKEDYAIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVASTGSGKTLAFVIPILIKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQKVTKIWSKESNYDCKVISIVGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVETLVLDEADKMIDLGFEDQVTNILTKVDINADSAVNRQTLMFTATMTPVIEKIAAGYMQKPVYATIGVETGSEPLIQQVVEYADNDEDKFKKLKPIVAKYDPPIIIFINYKQTADWLAEKFQKETNMKVTILHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRAANEGTAVSFVSAAEDESLIRELYKYVRKHDPLNSNIFSEAVKNKYNVGKQLSNEIIY
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, Helicase CA8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PAND_HELPH
Sequence: MTFEMLYSKIHRATITDANLNYIGSITIDEDLAKLAKLREGMKVEIVDVNNGERFSTYVILGKKRGEICVNGAAARKVAIGDVVIILAYASMNEDEINAHKPCIVLVDEKNEILEK
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX12_SCHPO
Sequence: MDSPSLLEVLQVQQVEKLISPSLRFILAYFTHRYPRFLLRAYNSFDGIYLLVKLLLEKSQLKKWNATSVERRFQLKRVIAVRDSSIIAEEFPQESESATSLNGIDVLKKLFLTYCIPYLLEKCESLTTVKENHTAVSILSLQARDKQKGALSVFYSKIKILLVRLKKILHFVFRLIRKSNTYLQWLYYLLYALGKTPYTNLADHILRQRVIYNVENIHSRKLISTREKSSLLTSIADHSMEGFLIIIQLIDWWQSNNYESHLKKGEVAFTELAPPKLPFEINVSTTDICKICGEKIKNPAVLSTGFVFCYPCIQVWLQRHPFKCPVTNLELSRKGESFWRLMI
What is the function of this protein?
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane.  PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10.  When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
What are the official names of this protein?
Peroxisome assembly protein 12, Peroxin-12.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
Protein: CISY3_ARATH
Sequence: MEISERVRARLAVLSGHLSEGKQDSPAIERWCTSADTSVAPLGSLKGTLTIVDERTGKNYKVPVSDDGTVKAVDFKKIVTGKEDKGLKLYDPGYLNTAPVRSSISYIDGDEGILRYRGYPIEEMAENSTFLEVAYLLMYGNLPSESQLSDWEFAVSQHSAVPQGVLDIIQSMPHDAHPMGVLVSAMSALSIFHPDANPALRGQDIYDSKQVRDKQIIRIIGKAPTIAAAAYLRMAGRPPVLPSGNLPYADNFLYMLDSLGNRSYKPNPRLARVLDILFILHAEHEMNCSTAAARHLASSGVDVYTAVAGAVGALYGPLHGGANEAVLKMLSEIGTVENIPEFIEGVKNRKRKMSGFGHRVYKNYDPRAKVIKNLADEVFSIVGKDPLIEVAVALEKAALSDDYFVKRKLYPNVDFYSGLIYRAMGFPPEFFTVLFAIPRMAGYLSHWKESLDDPDTKIMRPQQVYTGVWLRHYTPVRERIVTDDSKESDKLGQVATSNASRRRLAGSSV
What is the function of this protein?
Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG).  Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.
What are the official names of this protein?
Citrate synthase 3, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: NUOB_HYPNA
Sequence: MSDNSYKPYALGAARAGVDGGFKPGNDDPFYSGLSDQLADKGYFTAAADDLISWARTGSLMWMTFGLACCAVEMMHAGNPRYDLERFGMAPRGSPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALVYGFLQLQKKIRREGSIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EBP_ORYSJ
Sequence: MGHPHPHPYAPAELHLPGFVPLQLSQAQILVPYLATSLFLLLAVWLISGRCSRRLSDTDRWLMCWWAFTGLTHIIIEGTFVFAPNFFSNQNPSYFDEVWKEYSKGDSRYVARDPATVTVEGITAVLEGPASLLAVYAIASGKSYSHILQFTVCLGQLYGCLVYFITAYLDGFNFWTSPFYFWAYFIGANSSWVVIPTMIAIRSWKKICAAFQGEKVKTK
What is the function of this protein?
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
What are the official names of this protein?
Probable 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, Cholestenol Delta-isomerase, Delta(8)-Delta(7) sterol isomerase, D8-D7 sterol isomerase.
What is the protein family that this protein belongs to?
Belongs to the EBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FADI_ECOL5
Sequence: MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARTEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLRDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWSEGKLKEEVMTAFIPPYKQPLVEDNNIRGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMGDLTLIDMHEAFAAQTLANIQLLGSERFARDVLGRAHATGEVDESKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMD_SALEP
Sequence: MENIMTLPKIKHVRAWFIGGATAEKGAGGGDYHDQGGNHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLIVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLGATMYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGPDFWLMLDCWMSQDVNYATKLAHACAPFNLKWIEECLPPQQYEGYRELKRNAPAGMMVTSGEHHGTLQSFRTLAETGIDIMQPDVGWCGGLTTLVEIAALAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTLRPQFDPILLDEPVPVNGRIHKSVLDKPGFGVELNRDCHLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: FTSB_SALNS
Sequence: MGKLTLLLLALLVWLQYSLWFGKNGIHDYSRVNDDVVAQQATNAKLKARNDQLFAEIDDLNGGQEAIEERARNELSMTKPGETFYRLVPDASKRAATAGQTHR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RS4_THEMA
Sequence: MARYTGPLCKLCRREGMKLYLKGERCYTDKCAFDRRPYAPGQHGQRRTKLTQYGIQLRAKQTVKRIYGILERQFERYVEKAMQKAGDTRENLIQILEARLDNVVYRMGFAINRRQARQLVNHGHFLVNGKKVNIPSYLLRPNDVVEVREKSRDLEVIKKAIEANKERSIVPWIEVDYDNYRGTFLRYPSLEEVTDLPVDLQTVIEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RN133_MOUSE
Sequence: MNPLQTSTWQNQAPSFWLLRFSFIWLVSQKCCTASAVWTAYMNISFHVGNRMLSELGETGVFGRSSILKRVAGVVVPPEGKIQNACDPNTTFILPRNKEPWIALIERGGCAFTQKIKVASEHGARGVIIYNFPGTGNQVFPMSHQAFEDIVVVMIGNIKGMEILHLIRKGVHVTVMVEVGRKHVIWLNHYFVSFMIVTTATLAYFTFYHIRRLWVARIENRRWKRLTRELKKAFGQLQVRVLKEGDEEVNPNADSCVICFEAYKPNEIVRILTCKHFFHKNCIDPWILAHGTCPMCKCDILKALGIQMDIEDGTDSLQVLMSNELPGTLSPVEEETNYELPPARTSSKVTHVQEHPTSSANAGSQPPEAEETSHPSHGQQVL
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF133, Goliath-related E3 ubiquitin-protein ligase 2, RING finger protein 133, RING-type E3 ubiquitin transferase RNF133.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MED10_EMENI
Sequence: MAPITLSTIDGKLKDIIQHLFEIQSAVHGYLGPETQQELVRKIKNLTTALQTLSLHTRDDPTASTTAPNQYQSTNPNDPALHSIALPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKKEAFADFRDVLAREMRSAMPELRGEVDKVIQATGGKKQSERERG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y596_ACTPJ
Sequence: MLAIISPAKTLDFETPAPNFPFANSQPKLTAYSQQLIDICKQFSPAELGSLMSISDKLASLNVARFAEWQLAHNEQNAKAALFAFKGDVYTGLDAETLTQAQVEYAQVHLRMLSGLYGLLKPLDLMQPYRLEMGTKLVNPKGKDLYAFWGDIITQHLQTAMDEQGDNILVNLASDEYYGAVKPQKLQATIIKPVFLDEKNGKFKQISFYAKKARGMMVRFILETQPTSVEQLKAFNYGSYWFDEDASGATELVFKREEQA
What are the official names of this protein?
UPF0246 protein APJL_0596.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: URE2_BACSB
Sequence: MIPGEYVLKKEPILCNQNKQTIKIRVLNRGDRPVQVGSHFHFFEVNQSLQFHREKAFGMRLNIPAGTAVRFEPGDAKEVEIIPFSGERKVYGLNNVTNGSVEMGKRK
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTME_PENSI
Sequence: MGSLSSPTDLTPYQVLSKYKKFPSPDEEFWWDHAASTLADLIKWTKATPAQEYEFLQFFYEHVIPNFSGYRPYDVPGRAWNTGITPSGLPLEYSVNWRNIDANAMVRVGVEPISQFAGTARDPYSHYKIWDTLNQLSQVKALKSFDLELWRHFSSALCTSREEEALLDQTRTLPESFSIAKMQHSMGFDFCDDEVVVKIYLIPNMKARASGTPLAELLTGSIHAIYRDTIDRETLATVINYLDSTSNFNDATWFSFDCIPRSQSRIKLYGSDFRTTWSRAEDLWTVGGRYTDAVTMKGLAYLKELWDLLPIQDFETLPEQAVQNPPMLWAYEIRPGDKIPSPRIYIPGHCLNDKKVADGLSAFFKRVGWSDLGDQYTDRLFSMFPKQDLKDSTALHTWIAFSYTEKSGVYMNCYYLASASFPFKL
What is the function of this protein?
Aromatic prenyl transferase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Aromatic prenyl transferase ptmE, Penitrem biosynthesis cluster 2 protein E.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: SHH_DANAT
Sequence: YGRRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.  Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes.  Displays floor plate-inducing activity.  Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.  In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).
What are the official names of this protein?
Sonic hedgehog protein, SHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Secreted. Cell membrane. Note=Sonic hedgehog protein C-product: Secreted, extracellular space. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor. The C-terminal peptide diffuses from the cell, while the N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside.