PharMolix/UniProtQA huggingface dataset:
Protein: FIBA_SYNCA
Sequence: EDGSGEFLAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: KN12B_ARATH
Sequence: MKHFMMPRNAILRDIGESQSPNPSLTKSKSQRKIKSSKENAPPPDLNSLIPDHRSSPAKLKSPLPPRPPSSNPLKRKLIAEATADNGVAIGVSDSGVKVIVRMKPPSKGEEEEMIVKKISNDALTINEQTFTFDSIADPESTQDEIFQLVGAPLVENCLAGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLSGDQRGLTPRVFELLFARLSEEQAKHAERQLKYQCRCSFLEIYNEQITDLLDPSLKNLMIREDVKSGVYVENLTEEYVKNLKDLSKLLVKGLANRRTGATSVNAESSRSHCVFTCVVESHCKSVADGLSSFKTSRINLVDLAGSERQKLTGAAGDRLKEAGNINRSLSQLGNLINILAEISQTGKQRHIPYRDSRLTFLLQESLGGNAKLAMVCAVSPSQSCRSETFSTLRFAQRAKAIQNKAIVNEVMQDDVNFLREVIRQLRDELQRVKDDKGNNPTNPNAAYTTSWNARRSLSLLRSFGLGHPKSLPNGDDDGDTEMEIDEEAVERLCAQMGLSPPAEDNNQEMSRVEKINSSLQTVVLKDESYNNSHLKSSEATDVNMEDACCQTENNGSETDNALTVAETMDDGSSVQPDSITNSLHSCISDTNQGNSPSKAENIPSCQDLVIEADVSAIVSVADTSNNTEQVSVNPVSPCLSVAPVSVSPVLIPPTESASPKIRNSRKSLRTTSMSTASQKDIERANQLTPEVVEPSPAMSTEVLNLYSALSTKKSEAFPVPTRQLAASLHRGMKLLDSYRQSTALRRSTFRLSYKALECKPSTVLSKADVGVQTYPQADEIAEDNSKEVLCSRCKCRAECDAQEISDTSNLQLVPIDNSEGSEKSNFQVPKAVEKVLAGSIRREMAMEEFCTKQASEISQLNRLVQQYKHERECNAIIGQTREDKIVRLESLMDGVLSKDDFLDEEFASLMHEHKLLKDMYENHPEVLQTRIELKRVQEELESFKNFYGDMGEREVLLEEIHDLKAQLQCYTDSSLTSARRRGSLLKLTYACDPNQAPQLNTIPESVDEGPEKTLEQERLRWTEAESNWISLAEELRTELDTNRLLMEKQKRELDTEKRCAEELTEAMQMAMQGHARMIEQYADLEEKHIQLLARHRRIREGIDDVKKAAARAGVKGAESRFINALAAEISALKVQREKEVRYFRDENKSLQSQLRDTAEAVQAAGELLVRFKEAEEGLTFAQKRAMDAEYEASEAYKKVDKLKRKYETEISTVNQQHNAEPQNPIESLQASCNDDAMAKYDEPSASDGDNQWREEFQPFYKKDEELSKLAEPSWFSGYDRCNI
What is the function of this protein?
Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis.  Constitutes a signaling module in association with serine/threonine-protein kinase TIO that is required to support phragmoplast expansion and cell-plate growth in plant cells.
What are the official names of this protein?
Kinesin-like protein KIN-12B, Phragmoplast-associated kinesin-related protein 1-like protein, AtPAKRP1L.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, phragmoplast. Note=Localized to the midline of the nascent phragmoplast (late anaphase) and remains associated with the expanding phragmoplast ring.
Protein: RBL_GLAGU
Sequence: IASVVFKAGVKDYRLTYYTPEYETKDTDILAAFRVTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTNLDRYKGRCYHIEAXVGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAAFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREMTLGFVDLLRDDYIEKDRSRGIFFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREACNWSPGLAAACEVWKEI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPISY_SANSP
Sequence: MDSSTATATTAPFIDHTDHVNLKIDNDSSESRRMGNYKPSIWNYDFLQSLAIHHNIVEEKHLKLAEKLKGQVMSMFGAPMEPLAKLELVDVVQRLGLNHQFETEIKEALFSVYKDGSNGWWFGHLHATSLRFRLLRQCGLFIPQDVFKTFQSKTDEFDMKLCDNIKGLLSLYEASFLGWKGENILDEAKAFATKYLKNAWENISQKWLAKRVKHALALPLHWRVPRIEARWFIEAYEQEENMNPTLLKLAKLDFNMVQSIHQKEIGELARWWVTTGLDKLAFARNNLLQSYMWSCAIASDPKFKLARETIVEIGSVLTVVDDAYDVYGSMDELDHYTYSVERWSCVEIDKLPNTLKLIFMSMFNKTNEVGLRVQHERGYNGIPTFIKAWVEQCKAYQKEARWYHGGHTPPLEEYSLNGLVSIGFPLLLITGYIAIAENEAALDKVHPLPDLLHYSSLLSRLINDMGTSPDEMARGDNLKSIHCYMNETGASEEVAREHIKGIIEENWKILNQCCFDQSQFQEPFITFNLNSVRGSHFFYEFGDGFGVTDSWTKVDMKSVLIDPIPLGEE
What is the function of this protein?
Catalyzes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fragrance biosynthesis.  Catalyzes the formation of alpha-santalene, beta-santalene, epi-beta-santalene and exo-alpha-bergamotene, as well as traces of alpha-farnesene and beta-farnesene.
What are the official names of this protein?
Santalene synthase, SspiSSy, Alpha-santalene synthase, Beta-santalene synthase, Exo-alpha-bergamotene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
Protein: APOA2_MIRAN
Sequence: MKVLALAVLLLAVCSLEGAFVRRQAEEPNLQSLVAQYFQTMTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAGTDLINFLSNFMDLRTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_CHLCV
Sequence: MLMPKRTKFRKQQKGQFAGLSKGATFVDFGEFGMQTLERGWVTSRQIEACRVAINRYLKRKGKVWIRVFPDKSVTKKPAETRMGKGKGAPDHWVAVVRPGRILFEVANVSREDAQDALRRAAAKLGIRTRFVKRVERV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RL2_HAEIE
Sequence: MAIVKCKPTSAGRRHVVKIVNPELHKGKPYAPLLDTKSKTGGRNNYGRITTRHIGGGHKQHYRLIDFKRNKLDIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLSVGDQIQAGINSPIKVGNSLPMRNIPVGSTVHNVELKPGKGGQIARSAGAYVQIIAREGNYVTLRLRSGEMRKVLAECVATIGEVGNSEHMLRVLGKAGANRWRGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRHNKRTDKYIVRRRGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RT34_HUMAN
Sequence: MARKKVRPRLIAELARRVRALREQLNRPRDSQLYAVDYETLTRPFSGRRLPVRAWADVRRESRLLQLLGRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGKAWGILTFKGKTESEAREIEHVMYHDWRLVPKHEEEAFTAFTPAPEDSLASVPYPPLLRAMIIAERQKNGDTSTEEPMLNVQRIRMEPWDYPAKQEDKGRAKGTPV
What is the function of this protein?
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
What are the official names of this protein?
28S ribosomal protein S34, mitochondrial, MRP-S34, S34mt, Mitochondrial small ribosomal subunit protein mS34.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS34 family.
Protein: BCHN_ROSDO
Sequence: MTELPRLPAQGGCSNAPILKQRGQREVFCGLTGIIWLHRKMQDAFFLVVGSRTCAHLLQSAAGVMIFAEPRFGTAILEETDLAGLADAQAELDKVVDQLLARRTDIKQLFLVGSCPSEVIKLDLSRAAERMTEKYAPSVRVLNFSGSGIETTFTQGEDACLASMVPVLPKTDTRQLLLVGALPDVVEEQAVSLLEQMGIGPIKVLPAPRADTDLGIGENTVFALTQPFLGDTHGALERRGARHLPAPFPFGEEGTTAWLRVIADEFGVDADTFERVTAAPRARARKAISQASEALRGKTIFFFPDSQLEIPLARFLTRECGMEAIEVGSPFVHKGIIGSDLEMLAQGPVISEGQDVDLQLDRCRAARPDLTVCGLGLANPLEAEGLATKWAIELVFTPVHFYEQAGDLAGLFSRPVRRAGLLKVEAAE
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: ATPAM_MARPO
Sequence: MNKLAGAELSTLLEQRITNYYTKLQVDEIGRVVSVGDGIARVYGLNKIQAGEMVEFASGVKGMALNLENENVGIVIFGSDTAIKEGDIVKRTGSIVDVPVGKGMLGRVVDALGVPIDGKGALSAVERRRVEVKAPGIIARKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQINAQGTSDSEKLYCVYVAIGQKRSTVAQLVKILSEAGALEYSIIVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQSVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKMSDQTGAGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYRGSRPAINVGLSVSRVGSAAQLKAMKQVCGSLKLELAQYREVAAFAQFGSDLDAATQYLLNRGARLTEILKQAQYSPIPIEKQIVVIYAAVKGYLDQIPVALITHYEQELLKSIDPGLLSAIVQQKNITEQISSQLATFCQKFTQSFLATHQS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: YI32_SCHPO
Sequence: MNPSTSPNRNLASPKSLQLYTTGSEVAWYPTALDEANEIKSINSKAFSFKNQDQIYGAGSLKSRFSTHEISSEKNDSPDFTLVLPSNRLYIVIPGLMLSIFLAALDQTVITTAIPTIVANLDGGSSYSWIGTAYSLAETSILPFCGIMSEVVGRKIVLYTSIVLFLFGSAMCGAAQNMLWLVLCRAVQGIGGGGIMSLVTIVIADITPLQTRPYYTGCMGVTWGVASVMGPLIGGAISQNTTWRWIFFINLPTGGLSLALLIFFLNLVPKPTVSFCVFLRDFDFVGIVTITTGVVLFLLGLNIGSTTGHWAHANVLCYLIFGILCIAGFVVNELYTTRTRIIAPSAFQTLSLSSVMVTSFLHYYIMSTVTYYIPIYFQSIKGDGPLMSGVHTLSLAVVSSVVSAISGMGIGKLKNYRYPMIGGWIVLLAGTGSMIAIYYDTPIPRTMGFLALTAVGIGNLFQPNLIAIQASVPPALMATSCSAFMLLRNMGASVGISIGAVIYDQQLTTLLKGTEYSTGLSYSQIASIPSVSERNFVFNVYANAIRTIWIVNCPVAGVGMLLSFFTKQEKLSQSVTEYKEKDKGFKDAP
What are the official names of this protein?
Uncharacterized MFS-type transporter C1399.02.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PANB_BURM9
Sequence: MTYLQESSRPAVTVPKLQAMREAGEKIAMLTSYDASFAALLDRANVDVQLIGDSLGNVLQGQATTLPVTLDDIAYHTACVARAQPRGLVVADLPFGTYGTPADAFASAVKLMRAGAQMVKLEGGEWLAETVRFLVERAVPVCAHVGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAVEEAGAQLIVLEAVPTLVAAEVTRELSIPTIGIGAGAECSGQVLVLHDMLGVFPGKRPRFVKDFMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_CHRVO
Sequence: MKPTFLDFEQPIAELENKIEELRFVQDDSVLDISEEIARLQKKSLELTKTLYAKLTPSQIAMVARHPQRPYTLDYIQAIFTDFEELHGDRAFADDAAIVGGLARFNGQSVMVIGHQKGRDTKEKIRRNFGMPHPEGYRKALRLMKLAEKFGIPVLTFVDTTGAWPGIGAEERGQSEAIGRNLYEMTNLRVPIVVTVIGEGGSGGALAIAVGDHVNMLQYATYSVISPEGCASILWKTAERASDAAEALGITAPRLKTLGLIDRVVTEPVGGAHRDHAQMMTTLKRVLQDQLKEVQSKPMDALLKERFDRLMSYGRFKEDAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIB_MYCBO
Sequence: MSGMRVYLGADHAGYELKQRIIEHLKQTGHEPIDCGALRYDADDDYPAFCIAAATRTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVQTAALAREHNNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAQRHQRRIDILAEYERTHEAPPVPGAPA
What is the function of this protein?
Catalyzes the interconversion of ribulose-5-P and ribose-5-P.
What are the official names of this protein?
Ribose-5-phosphate isomerase B, Phosphoriboisomerase B.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: Y597_HAEIN
Sequence: MNLPFRAMVSDLDGTLLTPEHLVGDLTIDTLRALEQKGVDIILATGRNHTDVSSILGKIGAERAVMITSNGARVRDLQGNLLYSNSLPEELVLELYKTPFDTSKVCMNSYQDEGWFTNKDIPAMRQFHKESGFDYNVVDFSKHHGRGTEKVFFIGKTPEDLVEVETYLRDKFGDVTTIVYSALACLEVMNKNVSKGDALKHLLESREYELKDCIAFGDGMNDVEMLSWAGKGCIMKDADIRLKMACPELEVIGSNKEESVARYLRTQFGLDY
What are the official names of this protein?
Putative phosphatase HI_0597.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: SECA_OLILU
Sequence: MFNFLENEKYKLKEYQPLVNQINLLETSVKNYTDIELKEQFDKLRKEYFLSQNFSNDIIARSFSLTREAAFRTIGLRPFDQQLLGGLVLNSGKITEMKTGEGKTLVATLPAALNAISGRGVHIVTVNDYLAKRDSTWMGQIYDYLGLTVGLVQSQMESQERKDNYFQDITYITNSELGFDYLRDNQVKTFQEMVQRKFNYCIIDEVDAILIDEARTPLVLSIPDTIHNPKIYLDANTTAKSLIRDVDFKADEKTKNITFTDIGIDKIEYFRKIPNIYGTNAGFLFYLQNAISANIFFRKNSEYIIENNKIAIVDEFTGRVMPVRRWSNGLHEAIEAKESIDITQTSRISSSITYQNFFTLYPKLAGMTGTAKSAALELESIYNLEVVVIPTSKKFQRKDLPDKVYTNDFAKWKAIAKECFEIHKTGRPILVGTSSIEKSDFVSFLLENYKLQYNVLNARPENLKYESEIVGEAGCLNAITIATNMAGRGTDIILGGSPGFKIIRLLKILVLKVKLKEARTKKGLFLTHELYKELQKERLNYDAITQLVKFETEFGQKQIVRQKKLSTLFFYLKINYKSRFKKQKQYINQLGGLYVIGTERQDSKRIDNQLRGRAGRQGDAGSSRFFVSIEDKIFRLFGDNKFSNLFNQLNLTNEEISLESDLITKTLDNTQERVENYYYDIRKQVYDYDELITEQRKTFYLFRSKVLKTQVSGNLIIASTEDVIKKIVKSIKTPQLKFTNLTHKQENQIILEDFEQCRRIMRYALPPINLKQINASNHNVLFEFLMQEFWISYDIHKTKAFSSIGEEYYKEYERSCVLESIDHGWSTNLEKMETIRESIVWRVYAQKDPLAEYKKEGFSTFRKMDEEMKRFLVFAVFDTDFYVT
What is the function of this protein?
Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. Note=A minor fraction is associated with the chloroplast thylakoid membrane.
Protein: SSAP_SALTY
Sequence: MRITKVEGSLGLPCQSYQDDNEAEAERMDFEQLMHQALPIGENNPPAALNKNVVFTQRYRVSGGYLDGVECEVCESGGLIQLRINVPHHEIYRSMKALKQWLESQLLHMGYIISLEIFYVKNSE
What are the official names of this protein?
Secretion system apparatus protein SsaP.
Protein: ZY11B_MOUSE
Sequence: MPEDQAHAAMEEASPYSLLDICLSFLTTNLEKFCSARQDGTLCLQEPGVFPQEVADRLLQTIAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLMGKGHLKVSGEANETQIAEALRRYSERAFFVREALFHLFSLTHVMEKTKPDILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLALGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGAELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKEHEQTDPYVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN
What is the function of this protein?
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.  Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation.  Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites.  Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
What are the official names of this protein?
Protein zyg-11 homolog B.
What is the protein family that this protein belongs to?
Belongs to the zyg-11 family.
Protein: HIS6_RHOPA
Sequence: MFKVRVIPCLDVKDGRVVKGVNFVDLRDAGDPVEAAIAYDAAGADELCFLDITATHENRGIMLDVVRRTAEACFMPVTVGGGVRTVDDIKTLLRSGADKVSINSAAVARREFVKEAAEKFGDQCIVVAIDAKRVPGRDRWEIFTHGGRKGTGIDAIEFAQEVVSLGAGEILLTSMDRDGTKSGFDIPLTRAIADSVGVPVIASGGVGNLDHLVDGIREGHATAVLAASIFHFGEYTIRQAKDHMVQAGLPMRLDP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTF7_ARATH
Sequence: MQAKINSFFKPSSSSSIAASVTTDTDDGLAVWENNRNAIVNTYQRRSAITERSEVLKGCIEKTLKKGSSSVPKNHKKKRNYTQFHLELGQSDFLLRHCAECGAKYAPGDELDEKNHQSFHKDYMYGLPFKGWQNEKAFTSPLFIKNRIVMVSENDSPAHRNKVQEVVKMMEVELGEDWILHQHCKVYLFISSQRISGCLVAEPIKEAFKLIASPDDERQLQKESSSSPSTSIQFGNIVLQREVSKRCRTSDDRLDNGVIVCEEEAKPAVCGIRAIWVSPSNRRKGIATWLLDTTRESFCNNGCMLEKSQLAFSQPSSIGRSFGSKYFGTCSFLLYKAQLIDTHFS
What is the function of this protein?
Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:20671110).  Involved in preservation of genome integrity and meiosis (PubMed:23750584, PubMed:20671110).  Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division (PubMed:23750584, PubMed:20671110).  Knock-down mutants are extremely dwarf (PubMed:20671110).  Regulator of sister chromatid cohesion in meiosis which negatively regulates cohesin association with chromatin, acting as an antagonist of WAPL1 and WAPL2 (PubMed:26813623).
What are the official names of this protein?
Protein CHROMOSOME TRANSMISSION FIDELITY 7, Cohesion establishment factor CTF7, Protein ESTABLISHMENT OF COHESION 1.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ECO subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: OM25_BRUAB
Sequence: MRTLKSLVIVSAALLPFSATAFAADAIQEQPPVPAPVEVAPQYSWAGGYTGLYLGYGWNKAKTSTVGSIKPDDWKAGAFAGWNFQQDQIVYGVEGDAGYSWAKKSKDGLEVKQGFEGSLRARVGYDLNPVMPYLTAGIAGSQIKLNNGLDDESKFRVGWTAGAGLEAKLTDNILGRVEYRYTQYGNKNYDLAGTTVRNKLDTQDIRVGIGYKF
What are the official names of this protein?
25 kDa outer-membrane immunogenic protein.
What is the protein family that this protein belongs to?
Belongs to the Omp25/RopB family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: ALAA_ECOL6
Sequence: MSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQGTAFNWPWPDHFRIVTLPRVDDIELSLSKFARFLSGYHQL
What is the function of this protein?
Involved in the biosynthesis of alanine.  Catalyzes the transamination of pyruvate by glutamate, leading to the formation of L-alanine and 2-oxoglutarate.  Is also able to catalyze the reverse reaction.
What are the official names of this protein?
Glutamate-pyruvate aminotransferase AlaA.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSZ_SHIB3
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPX_HALH5
Sequence: MVTLLTSPSCTSCRKAKAWLEEHNIPFEERNIFSSPLTVEEVKEVVRMTEDGTDEIISTRSKVFQELDVELEALPLQTLFKIISENPGLLRRPIIFDEKRLQVGYNEAEIRRFLPRKVRTFQLQEAQRLVN
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
Protein: PANB2_BURCH
Sequence: MSAHTRITRKTVTAIRSTKGIGSLVSLTAYSAPMAKLVDEVADVIIVGDSVGMVLYGMPDTLRVTLDMMIAHGAAVVRGAAQACVVVDLPFSTFQESPAQAYRSAARLLAETGAQAVKLEGGCEMTDTIRFLTDRGIPVMAHVGLMPQQANAAGGFRAQGMDPRSAAQVFDAACAAERAGAFSVVIEGTAEALARHLTETLTIPTIGIGASPACDGQVLVTEDMIGAFDAYTPRFVKRYADANAVMRDAIRQYAHDVRQRVFPEPAHCFGYGKPLQLADAATAA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase 2, Ketopantoate hydroxymethyltransferase 2, KPHMT 2.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.