PharMolix/UniProtQA huggingface dataset:
Protein: KLD10_BOVIN
Sequence: MSAAQGWDRNRRRGGGAAGGGGGGSGAGGGSGGNGGRGTGQLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIERLK
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity).  Participates in the oxidative stress-induced cell death through MAP3K5 activation.  Inhibits PPP5C phosphatase activity on MAP3K5.  Acts as a regulator of necroptosis (By similarity).
What are the official names of this protein?
Kelch domain-containing protein 10.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SYI_NITSB
Sequence: MDYKETLLLPKTTFPMRGNLPQNEPKRFAKWFEKDVYEKMKKSREGKELFTLHDGPPYANGHIHIGHALNKILKDIIVKFNYFEGKAVRFTPGWDCHGLPIEQQVEKKLGTAKKEQLPKTKIRELCREHAAKFVGIQKEEFKNLGVIADWEKPYLTMDYAFEADIYRALCEIAKEGLLVERSKPVYWSWAAKTALAEAEVEYEDKVSPSIYVAFKLDKEAVQKIGKEASIIIWTTTPWTLPANTGIALNPDIEYVLTSDGYVVAADLLDELKEKGIVKGDVEKSISPKDLENLHAINPLNGRRSRIVLGEHVTTESGTGAVHTAPGHGEDDYRVGLKYDLEVLMPVDDAGRYDETIVREKLLPEEFVGMNVFEANDKICELLGDALLKKEDIKHSYPHCWRTHKPIIFRATKQWFIAVDKAPKDLQKTLRQIALEEVEKTTFYPEWGRNRLKSMIENRPDWCISRQRDWGVPIAFFRNKKTGEVIYDEKVLNYIAMIFERMGTDAWYSLSVEELLYPGSGYDPNDLEKVMDILDVWFDSGSTWYAVLKSRRYDAGNYPADLYLEGSDQHRGWFQSSLLVSGAIEKRAPFKAILTHGFTVDEKGEKMSKSKGNVVAPMDVAKKYGVEILRLWVAMSDYQSDLKISDNILKQIAEQYRKLRNTFRFMLANINDLETIQSDFGVLDRWILAKAKSVFEEVEKQFKNYQFAKGFSALNNFIVNEFSGIYLDVCKDRLYCDALNDSHRRASQSAMALIAKSMLGLIAPVLTYTADEIVEHAPSVLRNDAEDIFDFAIEPLPEIQSDFDEVYMIEARSKFNEIVDQLKKKKIIKSSLELVIETTSSKVLALDATEREDWFIVSGVEEEIGSKELGDFKVEGDQFIIKEAILHKCPRCWKYKAKEEGALCERCQKVVDGLEQAGS
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HN_SENDA
Sequence: MDGDRSKRDSYWSTSPGGSTTKLVSDSERSGKVDTWLLILAFTQWALSIATVIICIVIAARQGYSMERYSMTVEALNTSNKEVKESLTSLIRQEVITRAVNIQSSVQTGIPVLLNKNSRDVIQLIEKSCNRQELTQLCDSTIAVHHAEGIAPLEPHSFWRCPAGEPYLSSDPEVSLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPTVDERTDYSSDGIEDLVLDILDLKGRTKSHRYSNSEIDLDHPFSALYPSVGSGIATEGSLIFLGYGGLTTPLQGDTKCRIQGCQQVSQDTCNEALKITWLGGKQVVSVLIQVNDYLSERPRIRVTTVPITQNYLGAEGRLLKLGDQVYIYTRSSGWHSQLQIGVLDVSHPLTISWTPHEALSRPGNEDCNWYNTCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIMYSNTTNIINMLRIKDVKLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTSIPKLCKAES
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase, HN protein.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=Folded in the endoplasmic reticulum.
Protein: MPCP_PONAB
Sequence: MFSSVAHLARANPFNTPHLQLVHDGLGDFRSRPPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ
What is the function of this protein?
Transport of phosphate groups from the cytosol to the mitochondrial matrix.  Phosphate is cotransported with H(+).  May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).
What are the official names of this protein?
Phosphate carrier protein, mitochondrial, Phosphate transport protein, PTP, Solute carrier family 25 member 3.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BIOB_BRUSU
Sequence: MPDRGGENGASCSVGRWSAEEARAIYNLPFNDLLFRAHGLHRENFDPNRIQLSKLLNIKTGGCPEDCGYCSQSASAENGLKASKLMEIETVLEEARKAKAAGATRYCMGAAWRSPKDRDMPALTHMIESVKAMGLETCMTLGMLDSDKAEKLADAGLDYYNHNIDTSERFYPAVITTRSFEDRLDTLANVRNAGIKVCSGGILGLGEEAEDRIDMLVTLANLPEPPESVPINMLIPMPGTRLAKAAPVDPLEFVRVVALARILMPKSHVRLTAGRTAMSDEMQALCFFAGANSLFMGDTLLTAANPGDDRDSSLLRRLGIQAETEQPA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RS12_LACJO
Sequence: MPTINQLVRKGRHSKTTKSDSPALNYAYNSMKKKMNYNPAPQMRGVATRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGALDTAGVDGRKQGRSKYGAKKG
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RSMG_NITOC
Sequence: MDSIGENILEKGLLLLGVELDQSQVKVLLAYLRLLEKWNQHYNLTAIKNSKEMISKHVLDSLSIESYLEGRRILDVGSGAGLPGIPLAIARPGCEFVLLDSNAKKTRFLFQASVELGLPNISVVSERVEVYRPSHLFDTIIARAFAKLVDFVAQAEHLCKPRGCLLAMKGRFPQDELEALPASFEIVKACSLSVPEINAQRHLVKLRPRRAGDH
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IQCH_MOUSE
Sequence: MAQAQEDSDPIGSILIQVHEDLHQLKEKLVKFSAEETRSTLDIQNLETAIQRTEMGLKIHIDKYLGVVNQEVLMAPVKKSLESPVTSKWSIPTVIDQKSFIFPMDSDFWRPQKHRGSLLHGLRRAKPKIQLTTKVMQDPENKHHRAAVTASYGISLPHINQRKAQDKVQRLIKGSTISNLTVLPPSHRTDPHFIPIPVLQKDASKGVLSMIERGLIPPTARITFQNPPIKPQALPLHSFDEHRKVPMEASFPLALKPRPVPEEVEEPSHQIEIPKGRAKRSRGPLRRKGMKIRTPSKTRKSPWDYIFSVYNGCVDRTAPDFLAFKSRFKLIWGSIFSFLEQIEKFLKDYAISEAKIKGKSLVSLLPEFELKNKLTRNDVLAVLENPVHIQMLLNLPGQRYKGQDGKAEAATKIQATWKSYKARSSFISYRQKKWASGVIALAWLLHCHRTRLKRIVKESRQRHLENFRIRAQHLAANWSRIRTSRRTIIHIPSLGYSQYVRKHIFDLDVEQNMQLGRLCDIIDANVNVIYICSHPMTDELKLYYRKLLSLQAAVKTGYYGDRTDLQNRFRIITPEAVNVFTKHHMCLATHLMYSPKAIKRIKNLIRGEEAYIVGGILHRDDLAVADMLNVPILGSEPELVHLYSAKSGSKRIFDNANVPMPPGIYDIYTYQQMIEQLSQLVTDNLGIRRWVFKMNTEFGGNGTAFCDIPSHLQCYNWVLKERNRFGHEDWKKKWAQESALVKISEELAGILAQHVQLVNEKRFPTWRKFLHMFLTQGGVIEAYPPADSVTNLTVDMLIEPDGEVRVLSMGDQLHADGPFISSGTTMPQTSVDPQVLNSLCLQIGNICKEKDVVGYFSIDLVTFIDPSTLEQQVWTTGLNLSYSDQLAMTQLTLYLTNGHLNCSLSTLEVPRFTEDSERERKRLSIQAELAPETSRYAVMSTQLKHDNLSLIFYYVFLQMCKAHGIGYDLEDRQGTVFILYESLKRYKLGMLTIGVDLQGVLMTFARNLFIIHQEISAPDMQGETNFKTTIDDIETILGVTEENKMIFVREKQSKEEEDNLYEPVEIHSEIV
What is the function of this protein?
May play a regulatory role in spermatogenesis.
What are the official names of this protein?
IQ domain-containing protein H.
Protein: VP6_ROTBU
Sequence: MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHQATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices (PubMed:20122940).  This capsid constitutes the middle concentric layer of the viral mature particle (PubMed:20122940).  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus (By similarity).  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes (PubMed:20122940).  VP6 is required for the transcription activity of the DLP (By similarity).
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: VERM_CLORO
Sequence: MEAALKKLNIALQEAIDSFEGPLNQERLNELQTTESLPNKEVWSLASQTIDLADKIIHRLQPPSLQLAESFLAYLDTKCLWAAVSHDIPDLITAGGPQTVQELAKKSGLQSIRLKQVMRVLHNNGIFEYKPTTQKYSNTPSSTLLAKDHWTQWHLWVDLYGNEHYKAAEGIPDAIREGQTRCAAQIQYDTDESMFRYFARNGLQEKFHKTLGAGAVAQAPGMMADYNWGELDDAVVLDIGGGGGDFITSLLREHPSMRGGLFELDSVIEMVRPKYRDASGEFADVGDRMVDLHVGDFRVEVPAYEVYTMKWCLHNWLDEDVVKILSAVRRAIKVTPRARMVVVESVLKDGRSSRIWRFGDLTMMAGANGQEREEEDWRGLAAKTGWNIHSISPLRNAWAAAIDLRPC
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of 11'-deoxyverticillin A, one of the dimeric epipolythiodioxopiperazines (ETPs) from the verticillin family that act as mycotoxins (PubMed:28376389).  11'-deoxyverticillin A is required for normal conidiation (PubMed:28376389).  The nonribosomal peptide synthetase verP is speculated to be responsible for condensation of amino acids to form the carbon skeleton of verticillin, whereas the cluster-specific tailoring enzymes are involved in further modifications leading to the production of 11'-deoxyverticillin A (Probable).
What are the official names of this protein?
O-methyltransferase verK, Verticillin biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: PEPA_ASPNG
Sequence: MVVFSKTAALVLGLSTAVSAAPAPTRKGFTINQIARPANKTRTVNLPGLYARSLAKFGGTVPQSVKEAASKGSAVTTPQNNDEEYLTPVTVGKSTLHLDFDTGSADLWGFSDELPSSEQTGHDLYTPSSSATKLSGYSWDISYGDGSSASGDVYRDTVTVGGVTTNKQAVEAASKISSEFVQDTANDGLLGLAFSSINTVQPKAQTTFFDTVKSQLDSPLFAVQLKHDAPGVYDFGYIDDSKYTGSITYTDADSSQGYWGFSTDGYSIGDGSSSSSGFSAIADTGTTLILLDDEIVSAHYEQVSGAQESYEAGGYVFSCSTDLPDFTVVIGDYKAVVPGKYINYAPVSTGSSTCYGGIQSNSGLGLSILGDVFLKSQYVVFNSEGPKLGFAAQA
What is the function of this protein?
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates.  The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site.  Shows a broad primary substrate specificity.  Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.
What are the official names of this protein?
Aspergillopepsin-1, Aspartic protease pepA, Aspergillopepsin I, Aspergillopeptidase A, Proctase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAZ_GEODF
Sequence: MFRGNFETSIDAKGRTSLPAKFREVLVDSFGDERFFMTNSNPVRLGDGGYSSGLVIYPYNEWLALEEKLKVGTGLGLSSAELASVKRRIVAPAVECVADKLGRILVPPHLRKSACLEREILFVGMLNKAEIWSQAEWEKVFRQDIENFPIDSPVLAELGL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL6_ACIBT
Sequence: MSRVAKAPVTVPNGVTVTQNGRQVEVKGSKGTLSFNLHALVELKQEEGKLQLAPAKESKDAWMQAGTARAVLNNLVKGVSEGFERKLQLVGVGYKAAVKGTVVNLNLGYSHPIDYALPEGVTAETPTATEIILKSANKQLLGQVAAEIRAYRSPEPYKGKGVRYSDEVILRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PSA_GORB4
Sequence: MTFPYYASAEQIMRDRSELARKGIARGRSVVILTYADGVLFVAENPSNTLRKTSEIYDRIGFAAVGKYNEFESLRKAGIQLADMRGYSYDRADVSGLSLANTYANALGGVFTEQPKPFEVELCVAEVARYGKPKPSQLYRISYDGSITDETRFLVMGGATEPIAAALKESYQPDLELGAAVAVAVGALATPADSGNGTAASPRVLTAGDLEVAILDRNRPRRAFRRLSAAALEELLPTTGESDAGDSGADGSPSGDSPDTSA
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOT1_CAEEL
Sequence: MMNFEVSTTKQIGVGLTTFGFFFIFLGVLMFLDSALLAIGNLLFIVGITFIIGVQRTLVFFFEFRKLKGSILFFGGILVVLFGYPLFGMIAECWGFIVLFGGFLPGIVNLLRSIPGISTITYLPGIRQVLDRLAPESKYPV
What is the function of this protein?
May be involved in fusion of ER-derived transport vesicles with the Golgi complex (By similarity).  Involved in regulating AMsh glial cell size, acting by modulating the E3 ubiquitin ligase rnf-145/RNF145, probably by mediating the translocation of rnf-145 from the cis-Golgi to the trans-Golgi during development (PubMed:33370778).
What are the official names of this protein?
Probable Golgi transport protein 1, Enlarged amphid sheath glia protein 1.
What is the protein family that this protein belongs to?
Belongs to the GOT1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: SLYX_NEIMA
Sequence: MDAVQEFEHRITELEIQSALQEDVIAGLNAMVAELRQTLDLQQAQLRLLYQKMQDRNPDAQEPYSLRDEIPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: MUTL_AQUPY
Sequence: MFVKILPPEVRRKIAAGEVIDAPVDVVKELIENSLDAKATRIEIEVVKGGKRLIRVKDNGIGIHPEDIEKVVLSGATSKIEKETDLLNVETYGFRGEALYSISSVSKFRLRSRFYQEKEGREIEVEGGTLKSVRRVGMEVGTEVEVYDLFFNLPARKKFLRKEDTERRKITELVKEYAITNPQVDFHLFSEGKETLNLKKKDLKGRIEEIFESIFEEESSEREGIKVRAFISRNQKRGKYYLFVNSRPVYNKNLKEYLKKTFGYKTIVVLFIDIPPFLVDFNVHPKKKEVKFLKERKIYELIRELSSRKHTILEIPTLNQKTESYKPTYEVIGQLNETFILVSDGNFLYFIDQHLLDERINYEKNGNEELACRISVKAGEKLTNEKIKELIKEWKKLENPHVCPHGRPIYYKLPLKEVYEKLGRSF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DUT_XYLFT
Sequence: MSAAVKPLQIKILDPRLGTVWPLPTYATEASAGLDLRAALDAPMTLVPGDAELLSTGIAIHLVDPSLCAVVLPRSGLGHRHGIVLGNGTGLIDSDYQGPLLVSVWNRGREAFTIEPGDRIAQLVVLPIVRVVLQVVDTFVESGRGAGGFGHTGVR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: FARB_ASCSU
Sequence: SDIGISEPNFLRF
What are the official names of this protein?
FMRFamide-like neuropeptide AF11.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_ALKCK
Sequence: MLMPKRVKYRREHRGKMRGRAKGGTEVHFGEFGLQALEASWITNRQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKIMFEISGVSEEVAREALRLASHKLPIKCKFVKREEVGGDSNESN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HIG2B_HUMAN
Sequence: MATLGFVTPEAPFESSKPPIFEGLSPTVYSNPEGFKEKFLRKTRENPVVPIGFLCTAAVLTNGLYCFHQGNSQCSRLMMHTQIAAQGFTIAAILLGLAATAMKSPP
What are the official names of this protein?
Putative HIG1 domain family member 2B, HIG1 domain family member 2B pseudogene.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARL8A_CHICK
Sequence: MLALFNKLLDWFRALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
What is the function of this protein?
Plays a role in lysosome motility.  In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity).  May play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 8A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Note=Localizes with microtubules at the spindle mid-zone during mitosis.
Protein: ADPP_YEAST
Sequence: MFLRNVRVISLNSRRLFRTMSTVKGKPEDAKIIEARHVKETSDCKWIGLQKIIYKDPNGKEREWDSAVRTTRSSGGVDGIGILTILKYKDGKPDEILLQKQFRPPVEGVCIEMPAGLIDAGEDIDTAALRELKEETGYSGKIISKSPTVFNDPGFTNTNLCLVTVEVDMSLPENQKPVTQLEDNEFIECFSVELHKFPDEMVKLDQQGYKLDARVQNVAQGILMAKQYHIK
What are the official names of this protein?
ADP-ribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudF subfamily.
Protein: NRDR_STRGG
Sequence: MHCPFCRHPDSRVVDSRTTDDGTSIRRRRQCPDCSRRFTTVETCSLMVVKRSGVTEPFSRTKVISGVRKACQGRPVTEDALAKLGQRVEEAVRATGSAELTTHDVGLAILGPLQELDLVAYLRFASVYRAFDSLEDFEAAIVELRAQRPSAEDRGSGETLEVPAPAIAAD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TPMT_METCA
Sequence: MDPDFWHERWRQKQTGFHQTQVNPLLETFWPRCVGPARPRVFVPLCGKSLDMVWLRNRGHSVLGNELSPIAVDEFFRENGLSAVTTPLGNGFVRAESGDISLLCGNYFDLTPDLIGKVGAIYDRAALVAMPPEMQGRYAEQVFRLLPETPPMLLITLEYDAEEMSGPPFPVPEEAVVRLFGPAYRIELLSARDALEGNPQLRAKGLSRLTEKAYWLRAQASA
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THI42_VITVI
Sequence: MASMATTLTSLSSNPKPAFFDNKSSFHGSPISYRVLPIKVSHQSPTISMSSVSPYDLQSFKFEPIKESIVAREMTRRYMMDMITYADTDVVIVGAGSAGLSCAYELSKNPSIRVAIIEQSVSPGGGAWLGGQLFSAMVVRKPAHHFLDELGIEYDEQDNYVVIKHAALFTSTIMSKLLARPNVKLFNAVAAEDLIVKEERVAGVVTNWALVSMNHDTQSCMDPNVMEAKVVVSSCGHDGPFGATGVKRLKSIGMIDSVPGMKALDMNTAEDAIVRLTREIVPGMIVTGMEVAEIDGAPRMGPTFGAMMISGQKAAHLALRALGQPNAIDGNYTEAETMQPELILAAAETGEIVDA
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase 2, chloroplastic, Thiazole biosynthetic enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KCNG1_MOUSE
Sequence: MTLLPGDNSHYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRPQDDLHQSCSLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREEEEEPLDSEDQESEGPSASEGRLSRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.
What are the official names of this protein?
Potassium voltage-gated channel subfamily G member 1, Voltage-gated potassium channel subunit Kv6.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.