PharMolix/UniProtQA huggingface dataset:
Protein: MEF2C_HUMAN
Sequence: MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
What is the function of this protein?
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.  Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.  Enhances transcriptional activation mediated by SOX18.  Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.  Crucial for normal neuronal development, distribution, and electrical activity in the neocortex.  Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis.  Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.  May also be involved in neurogenesis and in the development of cortical architecture (By similarity).  Isoforms that lack the repressor domain are more active than isoform 1.
What are the official names of this protein?
Myocyte-specific enhancer factor 2C, Myocyte enhancer factor 2C.
What is the protein family that this protein belongs to?
Belongs to the MEF2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, sarcoplasm.
Protein: OPGD_SHIDS
Sequence: MDRRRFIKGSMAMAAVCGTSGIASLFSQAAFAADPDIADGQTQRFDFSILQSMAHDLAQTAWRGAPRPLPDTLATMTPQAYNSIQYDAEKSLWHNVENRQLDAQFFHMGMGFRRRVRMFSVDPATHLAREIHFRPELFKYNDAGVDTKQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDSKEEFPDFTAFWFDTVKPGATTFTVYALLDSASITGAYKFTIHCEKSQVIMDVENHLYARKDIKQLGIAPMTSMFSCGTNERRMCDAIHPQIHDSDRLSMWRGNGEWICRPLNNPQKLQFNAYTDNNPKGFGLLQLDRDFSHYQDIMGWYNKRPSLWVEPRNKWGKGTIGLMEIPTTGETLDNIVCFWQPEKAVKAGDEFAFQYRLYWSAQPPVHCPLARVMATRTGMGGFPEGWAPGEHYPEKWARRFAVDFVGGDLKAAAPKGIEPVITLSSGEAKQIEILYIEPIDGYRIQFDWYPTSDSTDPVDMRMYLRCQGDAISETWLYQYFPPAPDKRQYVDDRVMS
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VATB_MANSE
Sequence: MAKTLSAAQANKEHVLAVSRDFISQPRLTYKTVSGVNGPLVILDEVKFPKFSEIVQLKLADGTHRSGQVLEVSGSKAVVQVFEGTSGIDAKNTLCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPPILAEDFLDIQGQPINPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKIPGKSVLDDHEDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTAAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPVNVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYACYAIGKDVQAMKAVVGEEALTPDDLLYLEFLTKFEKNFITQGNYENRTVFESLDIGWQLLRIFPKEMLKRIPASILAEFYPRDSRH
What is the function of this protein?
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Essential for the proper assembly and activity of V-ATPase (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit B, V-ATPase subunit B, Vacuolar proton pump subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: YIDC_RICPU
Sequence: MNNNIINLIAAIILSLSIIFGWQYFVVKPEQKKQQQQIAVQKAENLKKQQLKALVEPATGIVVQEESQVQRIKIESESLTGSVSLKGLRFDDLILKKYKQDLSKNSPEVRLFSPANTENAYFAEVGLVSNLSSVKLPNNDTIWNSDSEILSPEKPVHLFWVNEDGVKFLVTITVDENYLFTIEQTIVNNSDKELPVQSYGLINRKYIAVEKAVNILHQGPIGCIDENLKEYSYDDIKDKKSEKFAASKVDWIGITDKYWLSSLIPDKSSNYSSNFNYALKQGTERYQVDFISPVQIIKPGENFSIKSRIFAGAKKVDLLDKYEKQYDIKLFDRAIDFGWFYIITKPVFYAMNFFYGYVGNFGVSILIVTVIIKLLMFTLANKSYRSMKKMKNLQPEIDRIKNLYSDDKARLNQEIMALYKKEKVNPVAGCLPILVQIPVFFSIYKVLYVTIEMRQAPFYGWIKDLSAPDPTTIFNLFGLLPFSPPSFLMIGAWPILMAITMFLQQKMSPEPADPMQAQVMKFMPLIFLFMFSSFPVGLLIYWSWNNILSIIQQYYINKFN
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXT_BACMK
Sequence: MVKIGVLGLQGAVREHVKSVEASGAEAVVVKRIEQLEEIDGLILPGGESTTMRRLIDKYAFMEPLRTFAKSGKPMFGTCAGMILLAKTLIGYEEAHIGAMDITVERNAFGRQKDSFEAALSIKGVGEDFVGVFIRAPYVVNVADDVEVLSMHGERMVAVRQGPFLAASFHPELTDDHRVTAYFVEMVKEAKMKKVV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: PA2A1_NAJKA
Sequence: MNPAHLLILAAVCVSPLGAFSNRPMPLNLYQFKNMIQCTVPNRSWWDFADYGCYCGRGGSGTPVDDLDRCCQVHDNCYNEAEKISRCWPYFKTYSYECSQGTLTCKGDNDACAAAVCDCDRLAAICFAGAPYNNNNYNIDLKARCQ
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (Probable).  Is able to suppress the acetylcholine (ACh)-evoked current mediated by alpha-7-similar nAChRs in L. stagnalis neurons (IC(50)=37 nM) and to compete with alpha-bungarotoxin for binding to muscle- and alpha-7 neuronal nAChR types, as well as to AChBPs (PubMed:25522251).  In inhibition of alpha-bungarotoxin binding, this toxin is similarly active against T. californica nAChR (IC(50)=1. 2 uM), human alpha-7 nAChR (IC(50)=3. 2 uM), and L. stagnalis AChBP (IC(50)=1. 0 uM), whereas it is not active against A. californica AChBP (IC(50)>100 uM) (PubMed:25522251).
What are the official names of this protein?
Acidic phospholipase A2 CM-II, CM 2, svPLA2, Acidic phospholipase A2 1, NnkPLA-I, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PTH_XANOR
Sequence: MSALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPVWLLKPATFMNLSGKSITAALRFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAAIGTAIDAAIDVLPLAMEGHFSEAMKRLHTSRDA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_LISMH
Sequence: MSGHSGHDVKYGRHRTRRSFARISEVLELPNLIEIQTASYQWFLDEGLREMFRDISPIEDFAGNLSLEFIDYDLGEPKYSVEESKNRDANYAAPLRVKLRLINKETGEVKDQEVFMGDFPLMTEMGTFIINGAERVIVSQLVRSPGVYFNGKLDKNGKKGFGSTVIPNRGAWLEYETDAKDVVHVRIDRTRKLPVTVLLRALGFGSDQEIIDLIGDNDYLRNTLEKDNTDNAEKALLEIYERLRPGEPPTVDNARSLLVSRFFDPKRYDLASVGRYKINKKLHLKNRLFNQTLAETLVDPETGEIIASKGDILDRRNLDQIIPNLENGVGFRTLRPTDGVMEDSVLVQSIKIYAPNDDEKEINIIGNAYIEENVKHITPSDIISSISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDMTTITPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRERAGYEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSFAKVNKFGFIETPYRRVDPETNRVTDKIDYLTADEEDNYVVAQANSKLDEQGTFTEEEVMARFRSENLAVEKERIDYMDVSPKQVVSVATACIPFLENDDSNRALMGANMQRQAVPLMHPEAPFVGTGMEHVSAKDSGAAVTAKHDGIVEHVEAREIWVRRVSLVDGKEVTGGIDKYTLRKFVRSNQGTCYNQRPNVAEGDRVVKGEILGNGPSMDSGELALGRNVLVAFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEFESEARDTKLGPEEMTRDIPNVGEDALRDLDERGIIRVGAEVKDNDLLVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVLDVKIFTREAGDELPPGVNQLVRVYIVQKRKIHEGDKMAGRHGNKGVISRILPEEDMPFMPDGTPVDIMLNPLGVPSRMNIGQVLELHLGMAARALGIHVATPVFDGANEEDVWSTVEEAGMARDAKTILYDGRSGEAFDNRISVGVMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTIKSDDVVGRVKTYEAIVKGESVPEPGVPESFKVLIKELQSLGMDVKMLSADEEEIEMRDMDDDDFTNQNDAFNIVQPENAAAEKTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MFA3L_MOUSE
Sequence: MGLQKSHLTVCLPPSVPFLILVSTLATAKSVTNSTLNGTDVVLGSVPVIIARTDHIIVKEGSSALINCSAYGFPDLEFKWYNSVGKLLKEMDDEKEKGGGKWQMLDGGLLNITKVSFSDRGKYTCVASNIYGTINNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAPDRDEVYTIPNSLKRSESPTADSDASSLHEQPQQIAIKVSVHPQSKRDHVDDQEGGHFEVKDEEETEPSEEHSPETAEPSTDITTTELTSEETSPVEAPERGLPPAHLETTEPAVTCDRNTCIIYESHV
What is the function of this protein?
May participate in the nuclear signaling of EGFR and MAPK1/ERK2.
What are the official names of this protein?
Microfibrillar-associated protein 3-like.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus.
Protein: PANC_RHOP2
Sequence: MPRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVFVNPTQFAPHEDFGSYPRTWKADVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAGLEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLRVVTRMAADLDLGVKVIGAPTIRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGFALDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOWR_HUMAN
Sequence: MSSSGGAPGASASSAPPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCITIHPLNIAAGVWMIMNAFILLLCEAPFCCQFIEFANTVAEKVDRLRSWQKAVFYCGMAVVPIVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETLEGEL
What are the official names of this protein?
Calcium channel flower homolog, Calcium channel flower domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel flower family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MURA_ECOK1
Sequence: MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_ACTPJ
Sequence: MSNIIKQIEQEQLKQNVPSFRPGDTLEVKVWVVEGSKRRLQAFEGVVIAIRNRGLHSAFTLRKVSNGVGVERVFQTHSPVVDSISVKRKGAVRKAKLYYLRERSGKSARIKERLGE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATPF_EMIHU
Sequence: MHLYTQTLNTVTGLLANEGSFGLNLDIFEANLINIVILGGGIFKLGSTALSESLAERQQKIVGAIQESEERLEQAVTKLTESEKQLAQAQLVITSLKEEAEATAKQVKSGILTDGKAEIERLTASAKGQIGTIEKKIRKEISEYVVTLALQRVTLQLEGKLDVNLQQQIIDKNISKLEG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NRDR_ALKCK
Sequence: MRCPKCQHNGTRVLDSRPSDESRSIKRRRECEKCLQRFTTYETVEERPLLIIKKDGMREEFSSDKMLRGLVRACEKRPVPLETLEKMVLDVERTLRNEGKQEVRSQDVGELVMERLAKIDDVAYVRFASVYRQFKDINVFIKELTELMNKN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HD5_ENCCU
Sequence: MSIRSKFNKDEKKFVKFIDSTEEIIKHLNKSDSSKRSRLKLSGQQIDVLESNFKIDSHPNSATKSLLSNALSIPLKNIQIWFQNRRAKEKTARDGGRRRSGNAEIEDGEYEHGKMSYQAMCPFDFPPQERYFL
What are the official names of this protein?
Homeobox protein HD-5, EcHD-5.
What are the subcellular locations of this protein?
Nucleus.
Protein: KRA34_SHEEP
Sequence: ACCARLCCSVPTSPATTICSSDKFCRCGVCLPSTCPHTVWFLQPTCCCDNRPPPCHIPQPSVPTCFLLNSSQPTPGLESINLTTYTQPSCEPCIPSCC
What is the function of this protein?
In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin, high sulfur matrix protein, IIIB4.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 3 family.
Protein: Y4VG_SINFN
Sequence: MSDLRRKRVKTNPIPDHVPPALVRHFSLFTSPGMAPTPNGDPHAAVACVHDDGPPIFYSPSNTRDGRGTWVITRARDQRRVLEDTETFSSHRSIFASALGEHWPVIPLELDPPAHGVFRALLNPLFSSRRVLALEPTIHARAGALIDCIAKEKTSCDVMKDFALPFTFSVFLSFLGLSQRRSEVLVGWVSDLLHGNAEKRRAAARSVVAFIDEMAAMRRKSPAVDFMTFVVQAKIEGRSLTEEEVRGIGVLFLVAGLDTVAAAIGFDMAYLARNPKHQELLRNEPARLGLAAEELLRAYSTVQIIRVATKDIEFEGVPIREGDYVSCPAMIANRDPSEFKCPNTIDLARQDNQHTAFGYGPHLCHGAHLARREIVIGLREWLARIPAFRIKEGTAPITHGGHVFGISNIILTWA
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Probable cytochrome P450 127A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: BAT1_ORYSJ
Sequence: MTWNKAPAADAEAGGGGDTGHARLRELGYKQELKRDLSVLSNFAFSFSIISVLTGITTLYNTGLSFGGPATMTFGWFVAGAFTMTVGLSMAEICSSFPTSGGLYYWSARLSGKRWAPFASWITGWFNIVGQWAVTTSVDFSLAQLIQVIILLSTGGNNGGGYMASKYVVIAFHAAILLSHAAINSLPITWLSFFGQFAAAWNMLGVFVLMIAVPTVATERASAKFVFTHFNTENNAGIHSNFYIFVLGLLMSQYTLTGYDASAHMTEETKNADRNGPIGIISAIGISIIVGWGYILGITFAVKDIPYLLNPENDAGGYAIAEVFYLAFKSRYGSGIGGIICLGIVAVAIYFCGMSSVTSNSRMAYAFSRDGAMPLSSVWHKVNKHEVPINAVWLSALISLCMALPSLGSLVAFQAMVSIATIGLYVAYALPILFRVTLARKHFVPGPFNLGRCGVAVGWAAVLWVATITVLFSLPVSYPVTKDTLNYTPVAVGGLFLLVLSSWLLSARHWFKGPITNLDG
What is the function of this protein?
May be involved in the transport of amino acids.
What are the official names of this protein?
Amino-acid permease BAT1 homolog.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THII_BACSU
Sequence: MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYFSNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKPGDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATFLTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSERAKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIREKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTYETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQEANDKFAELF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG12_SCLS1
Sequence: MTSSLLLTNLPHDSSSALEHAFSFPTAKITVRFQPIGSAPILQRPVSKISSSQQRFETVVAYLRRVLKLDRKGGEGDSVFLYVNSCFAPALDEVVGNLHRCFKDSKDQLIVTYSMTPAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: FTSH3_PHYMT
Sequence: MKYKKKNILFITTIIVIYLAFLFNWLEIGIFKPKGESISESEMLSKISRKDISESVRYSVYKTMFLKDKPFDIRNVYQIELTTHNNEKFHAEIIKNTKEELSFELLPRNKISYQYEFRPFSWLLSIFSILLNFINVLSSLVFTIYIFLAIHRESGKLNSKSLITSKQKSLFTFKDVAGNTEEKEEMTELIDFLKQPQKYETIGAAIPRGVLLEGPPGTGKTLLAKALAGEASVPFYAVSGSEFVEMYVGVGASRVRKLFKEAKLNAPCVLFIDEIDVLGGRRGGNSSGGNQEKDQTLNQLLTEMDGFTPSQGIIVIGATNRADMLDAALLRPGRFDRKILVNLPDIKSRAEILKLHAQNKKLSSDIDFHQLAQQTPGMSGAQLAAVLNEASILTVRNHKDFITMTELSEALDRVLMGPAKKSIKYDPEERRMVAYHEAGHAVIGIKLKHAQKVQKITIIPRGNAGGYNLMMPEKETFFSSRKRMLAQIQSFLGGRVAEELVFDDISSGAFDDFRQATKIARLMVTKYGMSDLGVSQDSEFSDKKLIDTAIKKIIDNCYARTKHLMLENKTLLDQIAHLLLEQETITQAEIEQLVVNTKK
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 3.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: IDH_MYCTO
Sequence: MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN
What are the official names of this protein?
Isocitrate dehydrogenase [NADP], IDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: SYFA_FRATN
Sequence: MQIVEQMKDKALAELNLVKDKKTLDDIRVKYLGKKGELTEMMKLIATLPNDEKPKLGQAVNIAKQALQEAINLKLANFEEQELNEKLAQEKIDITLSGVGQNQGSLHPVTKTLNRIEAFFKQNGFAIEFGPEIESDYYNFETLNIPSHHPARAMHDTFYIDETHVLRTHTSGVQIRTMEKQQPPIRIIAPGRVYRCDSDITHTPMFHQVEGLLVDKDVSFADLKGLLHAFLNSFFEKDLKVRFRPSYFPFTEPSAEADIECVMCDGKGCRVCKHTGWLEVLGCGMVHPKVLKAGNVDPEKYQGFAFGMGVERLSMLRYGIDDLRMFFENDLRFLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4XP_SINFN
Sequence: MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAALEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLVDELVAQLPDGIDAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCIDEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFDEEWMAKRRLLDPAIAAQLDGWLFGKARAA
What is the function of this protein?
As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction.
What are the official names of this protein?
Putative cysteine synthase, O-acetylserine (Thiol)-lyase, O-acetylserine sulfhydrylase, CSase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: ISC1_BOMMO
Sequence: DKPTTKPICEQAFGNSGPCFAYIKLYSYNQKTKKCEEFIYGGCQGNDNRFITLAECEQKCIK
What is the function of this protein?
Inhibits chymotrypsin and thus avoids the accidental chymotrypsin-mediated activation of prophenoloxidase.  This enzyme is required by the insect immune system to produce melanin which is used to engulf foreign objects.
What are the official names of this protein?
Chymotrypsin inhibitor SCI-I.