PharMolix/UniProtQA huggingface dataset:
Protein: NCAP_I83A4
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: S26A4_HUMAN
Sequence: MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
What is the function of this protein?
Sodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:12107249, PubMed:11932316, PubMed:16684826, PubMed:24051746).  Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:35601831, PubMed:24051746).  Mediates electroneutral iodide-bicarbonate exchange (By similarity).
What are the official names of this protein?
Pendrin, Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.
Protein: F16A1_CERS4
Sequence: MKPFPTHPDAIPAELQDVMDRLGSVAIEVANRIARGGIDEDLAGLCGTNTDGDGQKALDVIADDAFRVALEGSAVRFYASEEQDTAVTLNEAGTLALAIDPLDGSSNIDTNLSVGTIFAIWPAAATAEASFLRLGSELIAAGYVIYGPQVCMMVSFGKGTQKYVLDPGSRSFVLVDRAVKVPPSSTEFAINASNYRHWPKPIRAYIDDCVAGTEGPRGRNFNMRWLASLVAETHRILARGGVFLYPRDSRKGYEQGRLRYLYECAPIAFVITQAGGGATDGENPILGQTPSRLHARTPFVFGSAEKVARITAYHDLPEQETSALFGNRGLFRS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1488_STRZT
Sequence: MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLESFYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHVFITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSSEFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARRLNFAGFVYREDLSQPQGLVFVKEV
What are the official names of this protein?
UPF0246 protein SPT_1488.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PUR5_STAES
Sequence: MSKAYEESGVNIQAGYEAVERITSHVERTLRKEVLGGLGGFGATFDLSQLKMKAPVLVSGTDGVGTKLKLAIDYGKHDTIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPSTIEQIVKGISDGCEQTNTALIGGETAEMGEMYHEGEYDIAGFAVGAVEKEDYIDGSNVEEGQAIIGLASSGIHSNGYSLVRKMIKESGVQLHDQFNGQTFLETFLAPTKLYVKPILELKKHIDIKAMSHITGGGFYENIPRALPKGLSAKIDTQSFPTLEVFNWLQKQGNISTNEMYNIFNMGIGYTIIVDKKDVQTTLTTLRAMDTTAYEIGEIIKDDDTPIHLLEVE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_CAMHC
Sequence: MSRYTGPVEKLERRLGVDLFMKGERRLAGKSALLKRPYAPGQHGQRRAKVSEYGSQLREKQKAKFMYGLSEKQFRRLFKEAARREGNTGEILVQLLEQRLDNLVYRMGFATTRRFARQLVTHGHILVDGKRVDIPSYSVKVGQKIEIAEKSKNNPQILRAVELTAQTGIVAWVDVEKDKKFGIFTRKPERDEIVIPIEERFIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RBL_ALVHS
Sequence: MAKKYDAGVKDYRETYWMPDYTPKETDLLACFKIIPQPGVPREEARAAVAAESSTGTWTTVWTDLLTDLDHYKGRAYAIEDVPGDEEAFYAFIAYPIDLFEEGSVVNVFTSLVGNVFGFKAIRALRLEDVRFPIAYVMTCNGPPHGIQVERDIMNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRHGFDFVMEAIEKAERETGERKGHYLNVTAPTPDEMFKRAEYAKEIGAPIIMHDYITGGFTANTGLAQWCRDNGVLLHIHRAMHAVLDRNPHHGIHFRVLTKILRLSGGDHLHTGTVVGKLEGDREATLGWIDLLRESYIKEDRSRGIFFDQDWGSMPGVFAACSGGIHVWHMPALVTIFGEHAVLQFGGGTLGHPWGNAGAAANRVALEACVEARNEGHELEKEGKDILIQAAKHSPELKTAMETWKEIKFEFDTVDKLDVAHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: Y1399_PSE14
Sequence: MSSAICPCGSGDLLLACCGRYHAGQPAPCAEKLMRSRYSAYVLGLTDYLVQTTLPVQQSGLNREAIAQWSAQSTWLGLEVESSEVFGGKPEHAFVTFTARWHDGNGEHSHKERSSFVQNQGRWYFIDSTVPLKAGRNDACPCGSEQKFKKCCSPYVV
What are the official names of this protein?
UPF0225 protein PSPPH_1399.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: ADDA_CLOBB
Sequence: MSGTKWTEEQLSAITTRDCNLLVAAAAGSGKTAVLVERIIKIITNEENPIDIDKLLVVTFTSAAAAEMRERIANAISKKLDETPTSKNLQKQLTLLNRSNIMTIHSFCLGVIKNNFHKIDLDPSFRICDQTEGILLKMEIIDELFDDKYDEENQEFIKFIEAFSSYKSDNALKELVLSLYNFTMAGPWPKKWLKDASRDFDIKTLQELDETKWVNVLKESIKIELDGYIKMMQKAVKLINETDGLEPYFEGFSSELDLIVNAYNNVESSLNDLYNSLNLITFNRLKTIKKNTVSDENIQNLVKQIRDQVKKKISALIEGTFIASPDKMLDNIIKSYPYINQLTELTSEFIDRFTAKKKEKNILDFNDLEHLCLKILIEENEENQIVPSTIAQKFKDYFEEVLVDEYQDSNNVQEAIIELVSRKNSDNPNVFMVGDVKQSIYKFRQAKPELFIDKYNSYSLDKGINRKIQLYKNFRSREEIINGVNYIFKSVMSKTVGELEYTDVEALNLGANYPEKKNDDDIIGGPIEVHILDRSDNKEENDEFKLQAEEEIGDVNLEARIIVKRINELISKKEGNKFKVLDKDTGEYRDLKYKDIVILLRATKNWSEVLLDELGLAGIPVYADTGSGYFESIEIRTIMSLLKVIDNPMQDVPMLSLLISPIIGLSAEELSDIRLIDKEKYFYENIIKISKEKLISVELQEKCEYILSSIDKWRRKSIYMPIDEFIWYLYMDTAYYGYVGAMPNGVLRQANLKILFQRARQFSDTSFKGLFNFINFINKLTKSSGDMGSAKILGENEDVIRIMSIHKSKGLEFPVVFLAGCGKNFNLMDLNNKILYHEELGLGPEYINLENRTSITTLPKEAIKKRMKLETLSEEMRVLYVAFTRAKEKLIITGAVRNAEKSIEKWINSAVLDKDVVLPYEISKGKSYLDWIGMALCKHKDGEILRKKLGFSSEMCKDDLSMWKISIWNKYELDMYDELDENQEEEDVKISILDKDVNKEIKSEVYRRLGYEYEFKESTKLTSNISVSDLKKRNIEDDIDTLKMFDLEEEDNKNKDIITPKFLQEEKGISAAERGTAIHFAMKKIDFSKVGTLKEIKEQLNKLYDEELILQEEYNSINPYKILSFFKSSLGKKMLYVYNEGGKVYREVPFYTEISSLEIDESLPQKYANEKIRLQGIIDCFFKCDDEIILLDYKTDYVENEEEFKDKYKNQLSYYSEAIFKMTGKKVDKKYLYSFYLEKEILI
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: CFR_STAWA
Sequence: MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMKVLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESFCISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALANRQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERSKLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKSGKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQLYGNYQNSQ
What is the function of this protein?
Specifically methylates position 8 of adenine 2503 in 23S rRNA.  Confers resistance to some classes of antibiotics.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase Cfr, 23S rRNA (adenine(2503)-C(8))-methyltransferase, 23S rRNA m8A2503 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_CITK8
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDEGDAFYLHPGELALAVTFESVTLPPDLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRRQDAKYRDQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: PCP_STRPZ
Sequence: MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_HAEIR
Sequence: MGVPAGDVEKGKKIFVQRCAQCHTVEAGGKHKVGPNLHGLFGRKTGQAAGFAYTNANKAKGITWQDDTLFEYLENPKKYIPGTKMIFAGLKKPNERGDLIAYLKSATK
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: RL14_WOLTR
Sequence: MIQKNTLLEVADNSGAREVLCIGLLGGRKSASIGDTIVVSTKSVNPKGKVEKGKVYRAVVVRVKNCIRKSDNSVIRFSSNAVVLVNNQGEPLGTRVFGPVKKLPSGSFMKIMSLAVEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TAL_RALPJ
Sequence: MTQLDQLKQFTTVVADTGDFQAMRAYAPHDATTNPSLILKAVQKAEYRPLLEQAVRDARSDSVEDIIDAVLVAFGCEILSIIPGRVSTEVDARLSFDTEATVAKAKHLIALYEARGVARERVLIKIASTWEGIRAADQLRAEGIRCNMTLLFSLAQAVACAEAGVQLISPFVGRIYDWYKKDAGANWDPIAQGGPNDPGVQSVLRIYNYYKKFDYPTEVMGASFRNISQIVELAGCDLLTISPDLLAQLQQSDAPVERKLSPDNANAANIVRLPADEKSFRWHMNADAMATEKLAEGIRLFAADAIKLEALIEPLRAAA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_PROMH
Sequence: MSANALGMIIFAYLCGSISSAILICRLARLPDPRKFGSGNPGATNVLRIGGKLAAASVLICDVLKGMIPVWLAYYLNVPPFYLGIVAIAACLGHIYPVFFHFKGGKGVATAFGSIAAIGWDLSGLIAGTWLLTVLLSGYSSLGAIISALLAPFYVWWFKPEFTYPVALLSCLVLYRHHDNIQRLWRGQESRIWHKLKKKTEKTDKEIIQEAKEQEKED
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUB_DEIDV
Sequence: MPVLAVDKPLNLTSHDVVNRARRARGTRRVGHTGTLDPLATGVLVLCVDDSTKVVQFMEHDSKDYLAWVSLGAGTPTLDAEGPVDATAPVPPLDEDHIRGMLTTFCGPQQQIPPQYSAIQLGGQRAYAVARAGGTLELPARNIVIHSLDLLRVYPSVQAAPRMFSATPEGWSPDPQGQAFSLPEPLGEFPTLLLRASVGSGTYLRSLARDLGAALGVPAHLAGLVRTRVGRYDLSGAVSLEDLAEAPGIPDLEALDFPRIQASERLALELRQGKRPRHTAQGRHVVTLEGQLVAVVDGDGEQLKVVRAWA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y1444_DICTD
Sequence: MKLINIGFGNMVVSSRIVAIISPDSAPIKRFLSDAKTRNELIDATYGRKTRAVLVLDSGHIVLSALHPETIAARIEGGDKEEESS
What are the official names of this protein?
Putative regulatory protein Dtur_1444.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: MBD3_HUMAN
Sequence: MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV
What is the function of this protein?
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12124384, PubMed:16428440, PubMed:28977666).  Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863).  Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440).  Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175).  Recruits histone deacetylases and DNA methyltransferases.
What are the official names of this protein?
Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
Protein: NCBP1_DROPE
Sequence: MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLTFDTILCEALQHNLPQIIPPPHNDAFVYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSFPFKHKIPLEYCIVEVIFAELFHMPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDGEHPRPKFIQEVLQKCLRLSYHQRITEMMPTTYGKLIPQVPVPNFKYASEEAASLPGTAVAHQLVVAIRQKCSPEEVVNILKEIPNSGYSGEEMSDGTFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEAQICVLHNIYELWSSHQQMMVVLVDKLLKLQIVDCSAVATWIFSKEMTSEFTKMYLWEILHLTIKKMNKHVIKLNTELSVAKDKLSKADSSSSESDEDAPTKRKKPITHADKPSEEAVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHMLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVALRA
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRDR_DESRM
Sequence: MLCPFCSFPESRVLDSRPADEGNSIRRRRECGECGKRFTTYERVDERPLVVVKKDGRREVFDRAKLLAGFMKACEKRPVPVQRIEDTVHSIERELRSHGELEVLSQAVGELVMNSLLELDEVAYIRFASVYRQFGDIYSFLHEVEKLLKSKEDKKGAL
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MATK_PICSI
Sequence: MDEFHRYGKEDSSWQQCFLYPLFFQEDLYAISHDHYLDGSSSSEPMEHLSSNDQFSFLTVKRLIGQIRQQNHSIVLFVNCDPNPLVDRKKSSYSESVLEGLTLVLEVPFSIRSKYSVEGMNEWKSFRSIHSIFPFLEDKFPHSNYVSDTRIPYSIHPEILVRTFRRWIGDAPSLHPLRSILYEYRNSSESLQRSIIVVPKVNTRFFLFLWNNYVYECESILVSLLKRSSHSRSLSHGSFPQRTHFHRKIKNIFLFSRRNSLQSIWSLKDPNIHYVRYGERSIIAIKGTHLLVKKYRYYLPIFRQCYFHLWNEPYRVCSHQLSKNCSSSLGYFMRVRMKPLLVKTKMLDELFIADLITDEFDPIVPIVPIIGLLSREKFCDISGRPISKLSWTSLTDDDILDRFDRIWRNLFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKERELDSPPFSSKAAARSQRERIWHSDIPQINPLAHSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UT14C_HUMAN
Sequence: MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL
What is the function of this protein?
Essential for spermatogenesis.  May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 14 homolog C.
What is the protein family that this protein belongs to?
Belongs to the UTP14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL18_ALCBS
Sequence: MKDKKVARLRRAKRTRLKIRELGEVRLCVHRTPRHIYAQVISAAGDQVLASASTVEKDLRADATGNADAATKVGQIIAQRAKEAGIERVAFDRSGFKYHGRVKALADAARENGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CTRA_CAUVC
Sequence: MRVLLIEDDSATAQTIELMLKSEGFNVYTTDLGEEGVDLGKIYDYDLILLDLNLPDMSGIDVLRTLRVAKINTPIMILSGSSEIDTKVKTFAGGADDYMTKPFHKDEMIARIHAVVRRSKGHAQSVIKTGDIVVNLDAKTVEVNGNRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLAASAHGKHHIETVWGRGYVLRDPNEQVNAA
What is the function of this protein?
Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription.  Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.
What are the official names of this protein?
Cell cycle transcriptional regulator CtrA, Response regulator SokA.
Protein: DNAG_SYNY3
Sequence: MDNLRLHPDTIQEIKQRIDIVEIIGDYVVLKKRGRDHLGLCPFHDEKSPSFSVSPAKQMYYCFGCGAGGNAFNFLMELGKRSFTDVALDLARRYQIQIQTLEPAQKQELQRQLSLREQLYEIMAVAAGFYHHTLFQPQGQEALTYLDQKRCLSSATIQEFQLGYAPAGWETLYRYLVEQKRYPVAAVEQAGLIKARQSGTGYYDQFRHRLMIPIRDVQGKTIAFGSRTLGNDEPKYLNSPETPLFHKSKTLFGLDQAKTAIQKVDEAILVEGYFDVIALHESGIKQTVAALGIALSRDQVQSLMRFSQSKQIIFNFDADKAGINATQRAIQEIEPLVYSGQVNLRILNLPAGKDADEFIHSSAENKEIYQTLVKQAPLWVDWQIQQLLKQKNLKDPLDFEQVARGMVDILKRLTDQNKRAYYLQLCGEILSQGDSRLISLQVNNLSSQLTYGDRPGKNGSRHWQAKDPTSSLLEKAEALLLKIYLHCPQERPTIDQILTENDLLFSFAHHRLLWQKIDQVREYFNLDSDPDNQLPLLVQLAYLEQEGDFNSVESLFQLTETSAEDLFRANLRIPEAIAIMEKVPWESYQKHCFGKLQQLDPRTQAEDFRYYQEQWQKAHQEIQRLESQRLNQPLN
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.