PharMolix/UniProtQA huggingface dataset:
Protein: EUTL_CLOPE
Sequence: MKNDLIRPNVLSVKIISNVSPEMAKKLELEPHHKSLGLITADCDDVTYTALDEATKAAEVDVVYARSMYAGAGNASTKLAGEVIGILAGPSPAEVRSGLNATLDFIDSGVGFVSANEDDSICYYAQCVSRTGSYLSKTAGIREGEALAYLVAPPLEAMYALDAALKAADVEMCEFFAPPTETNFAGALLTGSQSACKAACDAFAEAVQSVASNPLGF
What is the function of this protein?
A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation.  May be involved in cofactor diffusion across the BMC (Probable).  Cobalamin is covalently bound to 1 subunit of the trimer on the concave (lumenal) face in a closed pore conformation; whether this is physiologically relevant is unclear (PubMed:25484204).  The closed form has 3 very narrow channels (1. 3 Angstrom at their narrowest) per trimer lined by acidic and aromatic residues; 2 ethanolamine molecules can bind in each channel, on either side of the constriction.  Does not bind acetate, ethanol or acetyl phosphate, all of which are small molecules involved in ethanolamine metabolism (PubMed:25752492).  Ethanolamine-binding has been hypothesized to stabilize the EutL central pore in a closed (non-transporting) state.  An open pore is thought to be large enough to transport ATP and/or cobalamin (Probable).
What are the official names of this protein?
Bacterial microcompartment shell protein EutL, BMC-T, Ethanolamine utilization protein EutL, EutL microcompartment shell protein.
What is the protein family that this protein belongs to?
Belongs to the EutL/PduB family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: FCGRB_HUMAN
Sequence: MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISQYTVKGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
What is the function of this protein?
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A.  May function in the humoral immune response.
What are the official names of this protein?
Putative high affinity immunoglobulin gamma Fc receptor IB, IgG Fc receptor IB, Fc gamma receptor IB pseudogene, Fc-gamma RIB, FcRIB, hFcgammaRIB.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. FCGR1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RUSD3_HUMAN
Sequence: MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ
What is the function of this protein?
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation.  Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379).  As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664).
What are the official names of this protein?
Mitochondrial mRNA pseudouridine synthase RPUSD3, RNA pseudouridylate synthase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
Protein: CDPKG_ARATH
Sequence: MGLCFSSAAKSSGHNRSSRNPHPHPPLTVVKSRPPRSPCSFMAVTIQKDHRTQPRRNATAKKTPTRHTPPHGKVREKVISNNGRRHGETIPYGKRVDFGYAKDFDHRYTIGKLLGHGQFGYTYVATDKKTGDRVAVKKIDKAKMTIPIAVEDVKREVKILQALTGHENVVRFYNAFEDKNSVYIVMELCEGGELLDRILARKDSRYSERDAAVVVRQMLKVAAECHLRGLVHRDMKPENFLFKSTEEDSPLKATDFGLSDFIKPGKKFHDIVGSAYYVAPEVLKRRSGPESDVWSIGVISYILLCGRRPFWDKTEDGIFKEVLKNKPDFRRKPWPTISNSAKDFVKKLLVKDPRARLTAAQALSHPWVREGGDASEIPIDISVLNNMRQFVKFSRLKQFALRALATTLDEEELADLRDQFDAIDVDKNGVISLEEMRQALAKDHPWKLKDARVAEILQAIDSNTDGFVDFGEFVAAALHVNQLEEHDSEKWQQRSRAAFEKFDIDGDGFITAEELRMHTGLKGSIEPLLEEADIDNDGKISLQEFRRLLRTASIKSRNVRSPPGYLISRKV
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase 16.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Nucleus. Note=Predominantly localized at the plasma membrane.
Protein: RNC_PSESM
Sequence: MSVSLSRLERQLGYTFKDQELMILALTHRSFAGRNNERLEFLGDAILNFVAGEALFERFPQAREGQLSRLRARLVKGETLALLARGFDLGEYLRLGSGELKSGGFRRESILADALEALIGAIYLDAGMEAARERVLAWLTTEFDSLTLVDTNKDPKTRLQEFLQSRACDLPRYEVVDIQGEPHCRTFFVECEINLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGHE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNPD3_MYCTU
Sequence: MHRLRAAEHPRPDYVLLHISDTHLIGGDRRLYGAVDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCYTQDLTVAAGGTRGRDGAQGCNLVHVYPDTVVHSVIPLGGGETVGTFVSPGQARRKIAESGIFIEPSRRDSLFKHPPMVLTSSAPRSPVD
What is the function of this protein?
Overexpression elicits a transcriptional response that is independent of the phosphodiesterase activity.  It does not alter the levels of cAMP-CRP regulated genes, even though cAMP levels are reduced in cells.
What are the official names of this protein?
cAMP/cGMP dual specificity phosphodiesterase Rv0805, 2',3'-cyclic-nucleotide phosphodiesterase, 3',5'-cyclic-nucleotide phosphodiesterase, Cyclic nucleotide phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase class-III family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Secreted, cell wall. Cell envelope. Note=The C-terminal extension (CTE) is necessary for the localization to the cell wall and cell envelope (PubMed:19801656, PubMed:24970891). Phosphorylation at Thr-309 promotes cell wall localization (PubMed:26904001).
Protein: G6PI_SYMTH
Sequence: MSSSLRFTVSPSLLGPHPHELTYQAEAIRIAHRMLHERTGPGAGFTGWLDLPERYDREEFRRIQEAAARIRGDSDVLVVIGIGGSYLGARATVEALGHAFHNLLPPERRGAPQIFFAGTDLSPRYLTELLDVLEDREVSLNVVSKSGTTTEPAIAFRLLRNWMERRYGKEGARRRIYATTDAARGALKQLADAEGYTRFVIPDDVGGRYSVLTAVGLLPIAAAGIDIDALMAGAAAAAAAYSDPDLERNPCYQYAAARNALYRKGMTTEVLVTYEPALKATAEWWKQLFGESEGKDGKGIFPAAAAFTTDLHSLGQYIQEGMRNLFETVVHVERPSVDIPLPPGDEGDGLGFLGGQTLHHVNHTAFLATRLAHTEGGVPNLTLTLPELTPYHYGYMLYFFMKACAISGYLLGVNPFDQPGVEAYKQNMYALLGKPGFEARRAEIEERL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSI_KLEP7
Sequence: MSEKHPGPLVVEGKLSDAERMKLESNYLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAAQKLEPRHAMLLRCRLPGGVITTTQWKAIDKFAAENTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQKKVATTDEEPILGQTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDKWHLTLFIENGRILDYPGRPLKTGLLEIAKVHQGEFRITANQNLIVASVPEDQKARIEKLARDHGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDKVEGVMSKHGVSDEHIVTRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHIGGNRNGTRIPRMYRENITESEILDSLDELVGRWAKEREAGEGFGDFTVRAGIIRPVLDPARDFWE
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: CBID_PROMP
Sequence: MKKGFSLPLWVTGAAKSAIKKLIGLPFEDYELIKIPKEKNLIKIKVHSAGLINEESQALGISFVDSGLDLDLTQNLEIWTIASLEKTYKTSNRPLDRINIIPGYGVGIDQKTSKICISDFAQKLLVENLLNIIPEGYTLNLEIVFPNGKFLAERTSNKSFGIVEGLSIIGTSAETFASASPDQLQNAKAQLKQIIANKVCDTIIFVIGENGLNLATSSNIKFPIIKVGNWIGPLLVDAAIQKIKTVILFGYHGKLIKLAGGIFHTHNHLADARIEILVYLAVKEEVPLEIIQKLSQSNTVEDALLVLESFSLSMADKLWNKLSDTIEKRSTEYINRYTKTDMKVGAIIFDRNRKIRWSGNNSKDYISAFKGF
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: RS10_MYCGE
Sequence: MNSAVKYPELKIKLESYDSTLLDLTIKKIVEVVKGVNIKIKGPLPLPTKKEVITIIRSPHVDKASREQFEKNTHKRLMILVDVNQGGIDSLKKIKIPVGVTLRFSK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: UVRC_BRUA2
Sequence: MKRLPNNPGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDVILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGPTRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP281_ARATH
Sequence: MAFSSCLKFYPFSISQAVTLTHHSFSLNLTPPSSTISFASPHSAALSSTDVKLLDSLRSQPDDSAALRLFNLASKKPNFSPEPALYEEILLRLGRSGSFDDMKKILEDMKSSRCEMGTSTFLILIESYAQFELQDEILSVVDWMIDEFGLKPDTHFYNRMLNLLVDGNSLKLVEISHAKMSVWGIKPDVSTFNVLIKALCRAHQLRPAILMLEDMPSYGLVPDEKTFTTVMQGYIEEGDLDGALRIREQMVEFGCSWSNVSVNVIVHGFCKEGRVEDALNFIQEMSNQDGFFPDQYTFNTLVNGLCKAGHVKHAIEIMDVMLQEGYDPDVYTYNSVISGLCKLGEVKEAVEVLDQMITRDCSPNTVTYNTLISTLCKENQVEEATELARVLTSKGILPDVCTFNSLIQGLCLTRNHRVAMELFEEMRSKGCEPDEFTYNMLIDSLCSKGKLDEALNMLKQMELSGCARSVITYNTLIDGFCKANKTREAEEIFDEMEVHGVSRNSVTYNTLIDGLCKSRRVEDAAQLMDQMIMEGQKPDKYTYNSLLTHFCRGGDIKKAADIVQAMTSNGCEPDIVTYGTLISGLCKAGRVEVASKLLRSIQMKGINLTPHAYNPVIQGLFRKRKTTEAINLFREMLEQNEAPPDAVSYRIVFRGLCNGGGPIREAVDFLVELLEKGFVPEFSSLYMLAEGLLTLSMEETLVKLVNMVMQKARFSEEEVSMVKGLLKIRKFQDALATLGGVLDSRQPRRTYRSR
What is the function of this protein?
May be involved in female gametophyte development.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g53700, chloroplastic, Protein MATERNAL EFFECT EMBRYO ARREST 40.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CCA_LIMF3
Sequence: MKIETLPAEFEPARPILSRIEEAGFEAYFVGGCVRDTILNLPIHDIDIATSAYPAEIKQIFSRTVDTGIEHGTVMILDHGTGYETTTFRTESGYQDFRRPDSVTFVRSLKEDLQRRDFTINALALKEDGTVVDLFDGLGDLKRHLIKAVGDPAERFHEDALRMMRAARFAAKLGFQIEPGTLAGMSQNAALLEKIAVERIQVEFEKLLLGKAVQNGLAAMLDTKLYLHCPGLKEGGQGLQYLAQQPLTLNNATQAWGALAICLGLDKNQLRPFLKGWKLSNGLITAVSRAVPLVEKLTTKTAGASDLYQAGQQAVADAVVIANSLGGQVDPQAVQAAYQALPIKESGELALNGGDLIKAGVKPGPAMGKALTTLTKQVVEGQLANDYQTLLKAAGELLKA
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: TIM10_ASPFU
Sequence: MSFLFGGPPKMSSAEKIAAAETEVEMVSDMFNRLTESCQKKCIPNDYREGDLNKGESVCLDRCVSKFFEVNIKVSEKMQGEAAQKQGAPGFGM
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim10.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: LDOX_PETHY
Sequence: MVNAVVTTPSRVESLAKSGIQAIPKEYVRPQEELNGIGNIFEEEKKDEGPQVPTIDLKEIDSEDKEIREKCHQLKKAAMEWGVMHLVNHGISDELINRVKVAGETFFDQPVEEKEKYANDQANGNVQGYGSKLANSACGQLEWEDYFFHCAFPEDKRDLSIWPKNPTDYTPATSEYAKQIRALATKILTVLSIGLGLEEGRLEKEVGGMEDLLLQMKINYYPKCPQPELALGVEAHTDVSALTFILHNMVPGLQLFYEGQWVTAKCVPNSIIMHIGDTIEILSNGKYKSILHRGVVNKEKVRFSWAIFCEPPKEKIILKPLPETVTEAEPPRFPPRTFAQHMAHKLFRKDDKDAAVEHKVFNEDELDTAAEHKVLKKDNQDAVAENKDIKEDEQCGPAEHKDIKEDGQGAAAENKVFKENNQDVAAEESK
What is the function of this protein?
Oxidation of leucoanthocyanidins into anthocyanidins.
What are the official names of this protein?
Leucoanthocyanidin dioxygenase, LDOX, Leucocyanidin oxygenase, Leucoanthocyanidin hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: DNAK_BURA4
Sequence: MGKIIGIDLGTTNSCVAIMEGNQVKVIENSEGTRTTPSIIAYMDDNEVLVGAPAKRQSVTNPRNTLFAVKRLIGRRFEEKEVQKDIGLMPYAIIKADNGDAWVEAHGEKLAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKAEKGDRKIAVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSSQQTEINLPYITADASGPKHLNLKITRAKLEALVEDLVERTIEPCRIAIKDAGVKVSDIDDVILVGGQTRMPKVQEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMISKNTTIPTKHAQVYSTADDNQSAVTIKVFQGEREMAAGNKLLGEFNLEGIPPSPRGVPQIEVTFDIDANGILHVGAKDKATGKENKITIKANSGLTDAEIDQMIKDAEANAAEDHKLRELADSRNQGDALVHSTKKALTEYGDKLDAGEKEKIEAALKSLEDALKDTSADKATIDAKVEELGQVSQKLGEKMYADMQAQQAGAAGAAGAAEGAAHAGGAQQAADDVVDAEFKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MURC_ACIC5
Sequence: MFAKAQRVHFIGIGGIGMSGIAEIVLNLGYAVSGSDLRRTSITARLESLGVVLFEGHAAANVIGSGVVVVSSAIDEENPEVREARARKIPVIQRAEMLAELMRLKYGIAVAGMHGKTTTTSMIASVLAAGELDPTVVVGGRVDALGSNARLGNSHYLVAEADESDRSFLKLSPILTVVTNLDREHMDCYRDMADVEDAFLEFMNRVPFYGANVACIDNPQLAALLPRVRRRVFTYGTSLGADFVVRMLPPAPEVRSRFEIASAQSVLGPFDLHVPGIHNVLNAAAAVAIAVQLDLKEQAIVQGLKSFRGVDRRFQLKGVVDGITIIDDYGHHPTEIRATLRAARDCGYANIHVLFQPHRYSRTRDLLDEFVTSFADASTVEMLDIYAASEAPLPGITSAALVQSIGQPGVRYAASTEEAVTAILDRAAPGDLILTLGAGNVSQLAPLLVERLQSRLPA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_ACTPJ
Sequence: MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHNYIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRSRPCLQYQIGRCLAPCVESYYSQAEYDNQVNLVRLFLQGKDGQVIEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQFVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQFYLQMNQHRTIPNQIIIDQPLSESAALADVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKTLLNLAEIKRMECFDISHTMGNQTVASCVVFDENGPLKSDYRRFNIEGITGGDDYAAMEQALLKRYSRHLEEEKIPDIIFIDGGKGQLNRALETFASLNVSWDKRKPLLIGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESIAGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLAEVIFDTLQHS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVH23_PHYSP
Sequence: MRLTYFLTVIVVATLHAGGTALATAEAPNHAAIVNVASADNVHSLDTTAEIGGRMLRKVKEDTVSKKDHEERGPGAILERQTAFVKKLFSRQNAIVNRAQGAFQRQNAFVNRDQGAFQRQNAFVKRAIQRQNHFKLSDNA
What is the function of this protein?
Effector that suppresses plant defense responses during the early stages of pathogen infection.  Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195).  Acts as a modulator of histone acetyltransferase (HAT) in plants.  Avh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5.  As such, Avh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility (PubMed:28318979).
What are the official names of this protein?
RxLR effector protein Avh23, Avirulence homolog protein 23.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm. Note=Location into the host nucleus is required for virulence.
Protein: SYE_ECOL6
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLTAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALAFIAERENQQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP161_BOVIN
Sequence: MSLNSSLGHRKELSNLTEGASDQGGSGVTEFVAIVIITVFVCLGNLVIVITLYRKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGIIAVDRYYAVLYPMAYPMKITGNRAVMVLAYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALLPFLVMLVCYGFIFRVARVKARKVHCGAVVTVEVGVQRTGRKNSSTSTSSSGSRKSAFQGVVYSANQCKALVTILVVIGAFMVTWGPYMVVITSEALWGKNCVSPTLETWATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGEQPLGNSSSTGDTGFSCSQDSGTDVMLLEDYTSDDNPLHGTCPPKRRSSVTFEDEVEQIKEAAKNPILHVKADVHKSLDSYATSLAKAIEAEAKINLFGEEALPGVLLTARTVPGIGFGSRRGSRTLAGQRLQLQSIEEGDVLATEQR
What is the function of this protein?
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development.  Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling.  In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.  Its ligand is unknown (By similarity).
What are the official names of this protein?
G protein-coupled receptor 161.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
Protein: RND_CROTZ
Sequence: MITTNDALAALCETARTQRALALDTEFVRTRTYYPQLGLIQLYDGENVALIDPLTITEWAPFQALLQDQNITKFLHAGSEDLEVFQNAFGMMPDPFIDTQVLASFVGHPLSCGFATLVEHHTGVALDKSESRTDWLARPLTERQCDYAAADVWYLLPIAHKLMEQVREAGWLTAAINECRLMTQRRGEVLDPDEAWREITNAWQLRPRQLACLKLLAGWRLRKARERDMAVNFVVREENLWKVARHMPGSLGELDGLGLSGSEIRFHGKTLLALVAQAQALLEDALPEPLANLVDMPGYRKVFKEIKALVQETSEAHKISAELMASRRQINQLLNWHWKLKPQNQLPELISGWRGELLGEALKTLLQNY
What is the function of this protein?
Exonuclease involved in the 3' processing of various precursor tRNAs.  Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
What are the official names of this protein?
Ribonuclease D, RNase D.
What is the protein family that this protein belongs to?
Belongs to the RNase D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NP03_VZVO
Sequence: MFSELPPSVPTALLQWGWGLHRGPCSIPNFKQVASQHSVQTDFTENSVDANENFPIGHAGCIEKTKDDYVPFDTLFMVSSIDELGRRQLTDTIRRSLIMNACEITVACTKTAAFSGRGVSRQKHVTLSKNKFNPSSHKSLQMFVLCQKTHAPRVRNLLYESIRARRPRRYYTRSTDGKSRPLVPVFVYEFTALDRVLLHKENTLTDQPINTENSGHGRTRT
What are the official names of this protein?
Nuclear phosphoprotein UL3 homolog, ORF58 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL3 family.
What are the subcellular locations of this protein?
Host nucleus.