PharMolix/UniProtQA huggingface dataset:
Protein: GATC_STAA8
Sequence: MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MLAE_SHIFL
Sequence: MLLNALASLGHKGIKTLRTFGRAGLMLFNALVGKPEFRKHAPLLVRQLYNVGVLSMLIIVVSGVFIGMVLGLQGYLVLTTYSAETSLGMLVALSLLRELGPVVAALLFAGRAGSALTAEIGLMRATEQLSSMEMMAVDPLRRVISPRFWAGVISLPLLTVIFVAVGIWGGSLVGVSWKGIDSGFFWSAMQNAVDWRMDLVNCLIKSVVFAITVTWISLFNGYDAIPTSAGISRATTRTVVHSSLAVLGLDFVLTALMFGN
What is the function of this protein?
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Intermembrane phospholipid transport system permease protein MlaE.
What is the protein family that this protein belongs to?
Belongs to the MlaE permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURA_SYNJA
Sequence: MANVVVVGAQWGDEGKGKITDLLSEKAHVVVRYQGGVNAGHTVVVGGQIFKLHLIPSGILYPDKRCIIASGTVIDPEVLLAEIDQLHQLGISTHNLYIAETAHVTLPYHRVIDVAEEERRGIYRLGTTGRGIGPTYADKAERMGIRVVDLMYPDQLRERLSWAIPYKNVLLEKIYNLPPLDPEPIIEQYLAYAERLRPYVTDAALLLTQAIEERQNILFEGAQGTLLDLDYGTYPYVTSSHPIAGGACVGAGIGPTSIDRVIGVAKAYTTRVGEGPFPTELKDEIGAYLGAAGAEFGTTTGRQRRCGWFDGVIGRYAVRINGLDCLAITKLDVLDGLDEIKVCVAYEYQGREIRHFPSDARVFAQCKPIYETLPGWKCSTKDCRSLEDLPPEAYDYLKFLAQLMQVPIAIVSLGASRDQTIIVEDPIHGPKRALLYPNGRKQVHALMPD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_CROS8
Sequence: MAPSFADVIAVVPAAGIGSRMQTECPKQYLTIGNQTILEHAVAPLLQHPRISRVIIAISPADTAFARLPLAAHPDIQVVRGGAQRADSVLAGLQAAGDARWALVHDAARPCLSAQDLERLLALTETSQVGGILAAPACDTMKRAEPGKPAIAHTVDRENLWHALTPQLFPLELLRDCLTRALAEGATITDEASALEHCGFHPELVAGRADNIKVTRPEDLALAAFYLTRLTPMETA
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: NCS1_XENLA
Sequence: MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDATGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNSDGKLTLQEFQEGSKADPSIVQALSLYDGLV
What is the function of this protein?
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner.  Directly regulates GRK1 (RHOK), but not GRK2 to GRK5.  Can substitute for calmodulin (By similarity).
What are the official names of this protein?
Neuronal calcium sensor 1, NCS-1, Frequenin.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Golgi apparatus. Postsynaptic density. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor.
Protein: CINA_SYMTH
Sequence: MIAELVFVGTELLLGEILNTNAQYLSRQLAQLGVDVYHQVVVGDNAARLRAVLSQALSRSDLVIASGGLGPTDDDITREVAAEVTGRPLELDPQLLAQLEIWFARRGRRMAENNRRQCMVPRGARVLPNDRGTAPGLMIPADGDKVVILLPGPPGELRPMFEAHVAPYLAARSGGRPLRLVTRTLRFVGIGESALADGLRDLMATQTDPTIAPYAKVAEVHLRLATRAADEAEGYARIAPLEAEIRSRFGRFLYGSDEETLPQAVGRLLAERGMTLSTAESCTGGLVAKWITDVPGSSRYFGTGFVTYANEAKVSLLGVPEELLSAHGAVSEPVARAMAEGALQRSGADVAVAVSGIAGPDGGTPEKPVGTVCFALAGRGRQGGGPLPAGTWAETLWLHGDRDGVRERAAVHALAMVRRYLLGYLD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: P2RY1_CHICK
Sequence: MTEALISAALNGTQPELLAGGWAAGNATTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
What is the function of this protein?
Receptor for extracellular adenine nucleotides such as ADP (PubMed:8508924).  In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
What are the official names of this protein?
P2Y purinoceptor 1, P2Y1, ATP receptor, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1738_CHRVO
Sequence: MTTPQAKPIDSYRKYWASRFGTAPFLPMTRAEMDELGWDSCDIILVTGDCYIDHPSFGMALVGRLLEAQGFRVGIIAQPDWHSADAFRELGKPNLFFGVTAGNMDSMINRYTADRRPRSDDAYTPNAEPNKRPDRAVTVYAQRCREAYPGIGVMIGSIEASLRRIAHYDYWSDKVRQSVLITSKADILLYGNAERALVEIAHRAAKGEKLSEMRDIRGTAFIVPHGWRPDEEWQEMDSSVVDIPGRVDPHLNPYQEIPEQAAEATKGIDPSKPQVIRIESREERLAKRRAERAKTVIRIPAYEAVAHDPVLYAHASRTLHLESNPGNARALVQMHGERDVWLTPPPIPLTTEEMDFVYGLPYARNPHPAYGDAHIPAWEMIKYSVNIMRGCFGGCTFCSITEHEGRIIQSRSEESILHEIEEIRDKTPGFTGHISDLGGPTANMYRLSCKDPKIERSCRKLSCVFPDICENLNTDHSHLIQLYRKARALPGVKKINIQSGLRYDLAVRSPEYIKELVQHHVGGYLKIAPEHTEDGPLSKMMKPGMGAYDKFKELFERFSRQAGKEQYLIPYFIAAHPGTSDEDMMNLALWLKKNNFRLDQVQTFTPTPMAMATTMWHTRRNPLKRLSRSSEKVDVVRDGYRRKLHKAFLRYHHPDNWQIIHDALIQMGRSDLIGHSKHCLIPPTPPGDKAAAVRHKMGAPMNRGKSPGARHPQQGQRAKPAAAVGARGQGGQGGRPGAGKPQAGRSPAKPGGKTSRSR
What are the official names of this protein?
UPF0313 protein CV_1738.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: HSP77_CANAL
Sequence: MLSARNSLKNISRQFPKALTRAQSTAAAPTGPVIGIDLGTTNSAVAVMEGKTPKILENSEGGRTTPSIVAFTKDGERLVGIPAKRQAVVNPSDTLFATKRLIGRRYEDPEVQRDINQVPYKIVKHGNGDAWLEARGEQYSPQQIGGFILNKMKETAEAALSKKVNSAVVTCPAYFNDAQRQATKDAGKIVGLNVLRVINEPTAAALAYGLEKKDGEVVAVFDLGGGTFDVSILDIGAGVFEVKSTNGDTHLGGEDFDIALVRYIVDAFKKESGIDLEKDKMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINQKISRAQFEQLVEPLIKKTIEPCKKALKDAGLSTSDVSEVILVGGMSRMPKVVETVKSIFGKEPSKGINPDEAVAMGAAIQGGILAGEVKDVVLLDVTPLSLGIETMGGVFARLISRNTTIPAKKSQIFSTAAAGQTSVEIRVFQGERELTRDNKLIGNFTLSGIPPAPKGVPQIEVTFDIDTDGIIKVSARDKATNKDASITVAGSSGLSDAEIEKMVNDAEKFAESDKARREAIEFANRADQLCNDTENSLNEHKEKLSSESVQKVQDQIQQLREIVLKAQAGEEVSPEELKQKTEELQNEAINLFKDLYKDGGESSGSSEQPKN
What is the function of this protein?
Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).
What are the official names of this protein?
Heat shock protein SSC1, mitochondrial, Cytoplasmic antigenic protein 6, mtHSP70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RR4_PHATC
Sequence: MSRYRGPKLKISRRLGTLPGLTTKKSNKLNRPGKDGNTDIGKKLTEYGVRLEEKQKLKFNYGLTEKQLFRYVKEARRRQGVTGLILLQLLEMRLDTLCFTLGFAKSLAQARQLVNHGHITINKKVVSIPSFQCRLNDIISIKEKSSSKTLVETNIKNNQVREIPTHLRFDTVKLEAIVLDYCDRNDVSLQLDELLVIEHYSRR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLPE_ECO57
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRNNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_LISMF
Sequence: MNNLQTQFPHIAIKLNEPLSKYTYTKTGGAADVFVMPKTIEETQEVVAYCHQNKIPLTILGNGSNLIIKDGGIRGVILHLDLLQTIERNNTQIIAMSGAKLIDTAKFALDESLSGLEFACGIPGSIGGALHMNAGAYGGEISDVLEAATVLTQTGELKKLKRSELKAAYRFSTIAEKNYIVLDATFSLALEEKNLIQAKMDELTAAREAKQPLEYPSCGSVFKRPPGHFAGKLIQDSGLQGHIIGGAQVSLKHAGFIVNIGGATATDYMNLIAYVQQTVREKFDVELETEVKIIGEDK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_LISMO
Sequence: MAKKGKKYQDALKQIDANKVYTAEEAVELAKKIDFAKFDATVEVAFRLGVDPKKADQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADYVGESEFVEKINQGWFDFDVIVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVTKAVNEIKAGKVEYRVDKAGNVHAAIGKVSFDAAKLVENFRTVNDVLQKAKPAAAKGTYVKNLSVTTTFGPGIKVDPASL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: NDPA_ACTPJ
Sequence: MSINVTEIVLHQIHQTEGETPELNTVLRDNLLAISPEVEQMMLQLHQAYQSKAKAYGIFKNESIFAQQLNRLLEQETDFLPFSHSCAKMLSSELAKYPFASGGTFILCRYNFLATDYLFIALIDSRTSMLVDDQLEIKRTEYLDITQYDIACRINLTELKINAQSNRYLTFIKGRVGRKIADFFMDFLSAEEGLNPQLQNQTLLQAVSDYCDQGELSAPQTREVKKQVFEYCKGQINSGEEIALSELSEALPTLNEVDFAQFTQEQEYGLEENIPPVRNALKTLTKYSGSGKGVTISFNADLLGERLIWDELNDTLTIKGLPANLRDQLARNK
What are the official names of this protein?
Nucleoid-associated protein APJL_0454.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PP265_ARATH
Sequence: MFLSHPPQVIQPTYHTVNFLPRSPLKPPSCSVALNNPSISSGAGAKISNNQLIQSLCKEGKLKQAIRVLSQESSPSQQTYELLILCCGHRSSLSDALRVHRHILDNGSDQDPFLATKLIGMYSDLGSVDYARKVFDKTRKRTIYVWNALFRALTLAGHGEEVLGLYWKMNRIGVESDRFTYTYVLKACVASECTVNHLMKGKEIHAHLTRRGYSSHVYIMTTLVDMYARFGCVDYASYVFGGMPVRNVVSWSAMIACYAKNGKAFEALRTFREMMRETKDSSPNSVTMVSVLQACASLAALEQGKLIHGYILRRGLDSILPVISALVTMYGRCGKLEVGQRVFDRMHDRDVVSWNSLISSYGVHGYGKKAIQIFEEMLANGASPTPVTFVSVLGACSHEGLVEEGKRLFETMWRDHGIKPQIEHYACMVDLLGRANRLDEAAKMVQDMRTEPGPKVWGSLLGSCRIHGNVELAERASRRLFALEPKNAGNYVLLADIYAEAQMWDEVKRVKKLLEHRGLQKLPGRCWMEVRRKMYSFVSVDEFNPLMEQIHAFLVKLAEDMKEKGYIPQTKGVLYELETEEKERIVLGHSEKLALAFGLINTSKGEPIRITKNLRLCEDCHLFTKFISKFMEKEILVRDVNRFHRFKNGVCSCGDYW
What is the function of this protein?
Required for the intergenic processing between chloroplast rsp7 and ndhB transcripts (PubMed:14617084).  Necessary for chloroplast NADH dehydrogenase-like (NDH) complex-dependent cyclic electron transport around PSI (CET) (PubMed:32978277).
What are the official names of this protein?
Pentatricopeptide repeat-containing protein CRR2, chloroplastic, Plant combinatorial and modular protein H54, AtPCMP-H54, Protein CHLORORESPIRATORY REDUCTION 2.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GON7_PIG
Sequence: MELLGEYVGQDGQRQRLRVPCEAPGNADHFQGLLSGVARMKELVAELFGSPVQGEAQDRVAAAPEEALDGDDEDDAEDENNIDNRTNSDGPTAKRPKPPS
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  GON7 plays a supporting role to the catalytic subunit OSGEP in the complex.
What are the official names of this protein?
EKC/KEOPS complex subunit GON7.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL21_BURA4
Sequence: MYAVIKTGGKQYKVAVGEKLKVEQIPADIDAEITLDQVLAVGEGESIKFGTPLVSGASVKATVVSHGRHAKVTIFKMRRRKHYQKHGGHRQNYTELRIDAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RL17_BOVIN
Sequence: MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CML17_ARATH
Sequence: MSHKVSKKLDEEQINELREIFRSFDRNKDGSLTQLELGSLLRALGVKPSPDQFETLIDKADTKSNGLVEFPEFVALVSPELLSPAKRTTPYTEEQLLRLFRIFDTDGNGFITAAELAHSMAKLGHALTVAELTGMIKEADSDGDGRINFQEFAKAINSAAFDDIWG
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML17, Calmodulin-like protein 17.
Protein: T2FB_RAT
Sequence: MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMKLKRLQIEESSKPVRLSQQADKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQTEEKSD
What is the function of this protein?
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.  It promotes transcription elongation.
What are the official names of this protein?
General transcription factor IIF subunit 2, Transcription initiation factor IIF subunit beta, TFIIF-beta, Transcription initiation factor RAP30.
What is the protein family that this protein belongs to?
Belongs to the TFIIF beta subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIMP_DROME
Sequence: MDLRKHLGLLTLLLVAVFAFYGRPADACSCMPSHPQTHFAQADYVVQLRVLRKSDTIEPGRTTYKVHIKRTYKATSEARRMLRDGRLSTPQDDAMCGINLDLGKVYIVAGRMPTLNICSYYKEYTRMTITERHGFSGGYAKATNCTVTPCFGERCFKGRNYADTCKWSPFGKCETNYSACMPHKVQTVNGVISRCRWRRTQLYRKCMSNP
What is the function of this protein?
Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro (PubMed:14567681).  Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor (By similarity).  Required for wing maturation which is the final step in morphogenesis of the adult fly (PubMed:16962574).  Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation (PubMed:17301221).  Required for oogenesis and for the long-term maintainance of germarial structure and shape in the adult ovaries.  Required for maintaining composition and biophysical properties of the extracellular matrix (ECM), and for the normal organization and cyst production of the germline stem cell (GSC) niche (PubMed:26808525).
What are the official names of this protein?
Tissue inhibitor of metalloproteinase.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIOX1_RAT
Sequence: MDELPNGNGAAPLKRGRGRRRRQPQPRGASVLALPLRPRKVRRHRKSAASRVAALRARALLSEDSDSNVESVRGKRERPAELPEASRSAEPRPVPVRPRPASATLPRRVEGRAALSRNLGKPAPLPGSHVDDPERPWDSPLQQVLAELNGIPSSRRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDHSYYEGLFSTSDLDWMLRYEDVHFGQHLDAARYIDGRRETLNPPGRALPAAAWSLYQAGCSLRLLCPQAFSPTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALTSSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAVLPLAMQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPIRWEAGEPVNVGAQLTTETQVHMLQDGIARLVGEGGRLFLYYTVENSRVYHLEEPKCLEIYPQQADAMELLLRSYPEFVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVLS
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity).  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.  Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2).  Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation.  Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity).  Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis.  Participates in MYC-induced transcriptional activation (By similarity).
What are the official names of this protein?
Ribosomal oxygenase 1, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: HIS7_ACET2
Sequence: MDRKFEVSRKTGETDITLSINIDGSGKSNISTGVGFFDHMLNLFAKHGLFDLDVKAKGDLEIDAHHTVEDVGIVLGQAIKQALGEKKSIRRYGSSFVPMDEALVLVALDLSGRPYLVFDAELKCEKLGNMETELVEEFFRAVAFNAGITLHVKALYGSNTHHIIEAMFKAFGRALDDATRKDDRIEGVMSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_RHOPB
Sequence: MADLQKIVDDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAGPAAAAAAPAEEKTEFTVVLAAAGEKKIEVIKEVRAITGLGLKEAKDLVEGAPKPVKEGVNKDEADKIKAQLEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: MNTR_BACVZ
Sequence: MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIEHHLSWNSIDRIGDLVQYFEDDESRKKELKSVQKKTENPGE
What is the function of this protein?
Central regulator of manganese homeostasis.
What are the official names of this protein?
HTH-type transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_THESQ
Sequence: MKKGIHPEMKLVTVKCACGAEHTFYTTVDNIRIDVCSKCHPFYTSGGKGGVLIVDTEGRVEKFRRKYGDNY
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: EX7L_STRU0
Sequence: MSDYLSVSHLTKYLKMKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDENAVIQATMWASAYKRLAFDLEEGMKINVIGRVQIYEPSGSYSIIIEEAVPDGIGALAIQFEQLKKKLTNEGFFDDKHKQDLPQFVQKVGVITSPSGAVIRDIITTISRRFPGVEILLFPTKVQGEGAAEEIVANISKANQREDLDLLIVGRGGGSIEDLWAFNEEIVVHAIFASQLPIISSVGHETDVTLSDFVADRRAATPTAAAELATPVTKADIISWISERQNRSYQATLRLLHQKRDQVMVLGQSVIFRQPERLYDAYLQKIDRLHNSLLNSIKSKLSDSRQAEMTVSHRLQTMNLLSTINRYQERLMTLNQWLNVDMQKQFDQLRTRFEKAQDALLTLDTKRIVARGYSIVRQEDKIISSVKDVSTGDLLAIEMRDGQIEVEVKNGN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRDD_ECOUT
Sequence: MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUN1_ASPFU
Sequence: MKFNTVALTLATAGSLVTAQHHHQHRHHQHKREDVVESSATVVQYELDGKPISLKQVCAGLADNTLKFANNDHPTGICDNLSSAAAPASTPEVTSAFAPAQFIELSSVVTSATPTSASSSETVQTPAASSSSASSSSTATGLDADFPDGELDCSTFPSEYGAIPLDYLKLGGWSGIQYVSYAGNFINDIVTAVAGDTCKDGAMCSYACPPGYQKSQWPSTQGATGQSVGGIECRNGKLHLTNPSLSKKLCIPGVGGVHVQNTLGETVAVCRTDYPGTESETIPIGLGGNDLQPLTCPDGETYYKWQGKTTSAQYYVNPKGVTPEKGCQWGDGTQPIGNWAPVNLGVGLNKGKWLSIFQNSPTTSEKLDFNIKIKGDNLSGSCKYENGVFYSETGSSSSGCTVQVMSGDATFVFY
What is the function of this protein?
Cell surface beta-glucosidase involved in cell wall biosynthesis and septation, and thus required for normal growth and correct hyphal morphogenesis.  Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides.  Has also a minor transferase activity.
What are the official names of this protein?
Secreted beta-glucosidase sun1.
What is the protein family that this protein belongs to?
Belongs to the SUN family.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted.
Protein: KTHY_LACH4
Sequence: MRGYFVSFEGPDGAGKSTVLKEVLDQIGPKLKPQYLVTREPGGSKIAEKIRDIILDPANDKMDAKTEALLYAAARSQHVEEIIRPALSEGKIVFSDRFVDSSLAYQGEGRDLGIEEVKQINDFATGKLDPDLTFFLDIAPEIGLSRIQKLRPGQEDRLEQENIAFHKKVYNGFLKVKDLYPDRFVTIDATQPIEDVVNQVIATLEKRLPEIF
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.