PharMolix/UniProtQA huggingface dataset:
Protein: CYB_CONVI
Sequence: MAPNLRKHHPLLKMVNNSLIDLPTPSNISAWWNFGSLLGICLATQIITGLLLAMHYTADTSLAFMSVAHTCRNVQFGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTLIHLTFLHETGSNNPLGISSDCDKIPFHPYFSTKDILGFIILFLPLMTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASVLVLFLAPFLHMSKQRTMTFRPLSQLLFWTLVANLLILTWIGSQPVEHPFIIIGQLASLTYFTILLILFPIVGTLENKLLKF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOC_STRA1
Sequence: MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIICDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPMDTPLEPKSLLTEREYREKLQEYGYGSFVAKMGAEAIQDLLKRVDLDAEIAVLKEELKSATGQKRVKAVRRLDVLDAFKKSGNKPEWMVLNILPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDLAGNVKAAKRMVERGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDAGREGEGMIFKDHDEAVMAYQNGYVHLHTRVGIAVDSMPNKPWTEEQKHKIMVTTVGKILFNDIMPEDLPYLIEPNNANLTEKTPDKYFLEPGQDIQAVIDNLEINIPFKKKNLGNIIAETFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIDAAHHRVEDINKAFRRGLMTEEDRYVAVTTTWREAKEALEKRLIETQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLTITAITDGKEVTETLEERLIGRYTKKSIKHPETGEILVGADTLITEDMAAKVVKAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAVITEVKGEVVAIEEDSSTRTKKVFVKGQTGEGEYVVPFTARMKVEVGDEVARGAALTEGSIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDISDFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPLAVNEVEIIEGTPVDAEVTEVSTPTTED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RS10_BIFLD
Sequence: MAGQKIRIRLKSYDHEVIDQSAKKIVETVTNAGATVVGPVPLPTEKNVFCVIRSPHKYKDSREHFEMRTHKRLIDIVDPTPKAVDSLMHIDLPADVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PYRK_METAR
Sequence: MRPISATIKEIIDETPTIKTFRLDVDDWLHGKPGQYVMVWIRGVDEVPMTLSYDNAITVQKVGEATEALFKLKAGDSVGIRGPYGNGWEIVGDDILLISGGVGSAPLAPLGEKARRIGVNVTTLAGYRTKEEVHFEDRYRAAGELVVATDDGTYGKKGYVTDLLKSVDLKKFTQIYCCGPEKMMYRVLCALDEAGVAGLSQFSLQRYIKCGIGVCGSCCMDPDGLRVCRDGPVFDGETLLRSEMGKYARDASGRRQQI
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: TRPA_MYCTU
Sequence: MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVESGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIFLVAPSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAPELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVRLGMSA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: CG121_DEBHA
Sequence: MVYEELKLAQFPNCTVLIFLFTGVDTPVLKQVKEQLISGNKDYDFCFLNPQHIISLEHLYSSIHKAVLNHEFGNMRAKTLNTEIIFNLSPINNIMDALKRFGVDEACPNLITIKVLPTSECNEIAFKDLNDHLLKILSTNDSHNPRLNNEIIFDSLVDLKKLKKVYKLNDAKFSKDESDLQGELTRLAIGACQLRGC
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.  CGI121 is not required for tRNA modification (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit CGI121.
What is the protein family that this protein belongs to?
Belongs to the CGI121/TPRKB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: MBHS_ECOLI
Sequence: MNNEETFYQAMRRQGVTRRSFLKYCSLAATSLGLGAGMAPKIAWALENKPRIPVVWIHGLECTCCTESFIRSAHPLAKDVILSLISLDYDDTLMAAAGTQAEEVFEDIITQYNGKYILAVEGNPPLGEQGMFCISSGRPFIEKLKRAAAGASAIIAWGTCASWGCVQAARPNPTQATPIDKVITDKPIIKVPGCPPIPDVMSAIITYMVTFDRLPDVDRMGRPLMFYGQRIHDKCYRRAHFDAGEFVQSWDDDAARKGYCLYKMGCKGPTTYNACSSTRWNDGVSFPIQSGHGCLGCAENGFWDRGSFYSRVVDIPQMGTHSTADTVGLTALGVVAAAVGVHAVASAVDQRRRHNQQPTETEHQPGNEDKQA
What is the function of this protein?
This is one of three E. coli hydrogenases synthesized in response to different physiological conditions.  HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
What are the official names of this protein?
Hydrogenase-1 small chain, HYD1, Membrane-bound hydrogenase 1 small subunit, NiFe hydrogenase.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein; Periplasmic side.
Protein: ISPDF_CAMC1
Sequence: MLDISLIMLGAGNSSRFELPVKKQWLRIGSDPLWLFATKNLSNFYTFKEIIVVSKECKYMSKFAPNYKFVDGGETRQDSLKNALELVSSEFVLVSDIARPCISSELFHKIIEAAAQADCVVPALKIADTAYLGENAIDREKVKLIQTPQLSRTTLLKKALSSGEIYTDDSSAMRAIGASVWHILGDEMARKITFKEDLVKISALKAPENELFVGSGFDVHEFEKGRPLVLCGEKIDYEFGLKAHSDGDVALHALTDAILGAAGLGDIGELFPDTDDKFKDISSIYLLQEAYKRVQSVGFVLTNADITIMAQKPKLSKLKSKMEANIAQALNLSQSRINVKATTTEGLGFVGRCEGIAVMASASLKFYNWTQI
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: RL14_CHLTA
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDVIVCSVRDVEPDSSVKKGDVVKAVIVRTRNDIHRKDGSTLRFDTNSCVIIDDKGNPKGTRIFGPIAREIRDRGFVKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: HRCA_LISMC
Sequence: MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHSSSGRVPSEKGYRFYVDYLLQPKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNYTSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDNHLVTIPEGTTLSDIERMVNILNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNILNQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNIAGERVGGIVLLGPTRMEYSRMMGLVDVMSRDLTDVLTKLYRDNQN
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: KHSE_STAAN
Sequence: MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEVKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_YEAS8
Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQATEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: IABF_HALH5
Sequence: MTLTATMVVDKSFKIGEIDKRIYGSFIEHLGRAVYEGIYEPGHPDGDEQGFRKDVIRLVQELQVPLVRYPGGNFVSGYNWEDGVGPVSERPKRLDLAWRTTETNEIGTNEFVDWAKKVGAEVNMAVNLGSRGVDAARNLVEYCNHPSGSYWSDLRISHGYKDPHNIKTWCLGNEMDGPWQIGQKTAEEYGRVAAEAGKVMKLVDPSIELVACGSSNSKMATFADWEATVLDHTYDYVDYISLHTYYGNRDDDLANYLAQSMDMDEFIRSVIAIADYVKAKKRSKKTIHLSFDEWNVWFHSNEADRQITPWSVAPPLLEDIYTFEDALLVGSMLITLLKHADRVKIACLAQLVNVIAPIMTEKGGPAWKQTIFYPYMHASVYGRGVALQAQISSPKYDSKDFTDVPYLDAAVVHLEEAEEVTIFAVNKHQTESLNLQCDMRSFEGYHVLEHIVLEHENMKATNQGREQVTPHHNGDSAIDQGRLTANLAKLSWNVIRLGKK
What is the function of this protein?
Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall.  Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (branched and debranched arabinans) (By similarity).
What are the official names of this protein?
Intracellular exo-alpha-(1->5)-L-arabinofuranosidase, ABF, Intracellular arabinan exo-alpha-(1->5)-L-arabinosidase, Arabinosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 51 family.
Protein: COAX_ALKMQ
Sequence: MILVVDVGNTNIVLGLYEKQELVDFWRISTDEDKSSDEYSVLINQLFQYSGLNIKTVEDVIISSVVPNIMYSLEHAIRKLCNVEPLVVGPGVKTGINIKYDNPKQVGADRIVNAVAAFEKYGGPLIVVDFGTATTFCAISGHGEYLGGTISPGIKIASDALFQRAAKLPRVELVKPGKVICKSTVSSMQAGIVYGYVGLVEYIVNKMKKEFNVRSKIKVVATGGLSTLIDSETQCIDVVDKFLTLEGLSLIYERNRQERQAILKESQA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_STAAS
Sequence: MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTEEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ENV2_MOUSE
Sequence: MESPAFSKPLKDKTIKKALLGVLGILLVTGGLAHKDSPHLIYNLTWEVTNGEQETVWAVTGNHPLWTWWPDLTPDLCMLALHGPTHWGLDNRPPYSSPPGPPCCSGDKGAVSGCARDCDEPLTSYSPRCNTAWNRMKLAQVTHAPKEGFYVCPGSHRPRWARSCGGPEAYYCASWGCETTGRAAWKPTSSWDYITVSNNLSSPQAPKACKNNGWCNPLVVRFTGPGKRATSWTTGHEWGLRLYISGHDPGLTFGIRLRITDLGPRVPIGPNPVLSDQRPPSRPVPARPPPPSNSTPTGDPLTPPTGDPLTPTKPPQAGTGDRLLNLVQGAYLALNMTNPTKTQECWLCLVSEPPYYEGVAVLGDYTKHETAPTNCSSRAQHKLTLSEVTGQGKCLGAVPKTHQALCNHTEPTVSGSNYLVAPEGTLWACSTGLTPCLSTTVLNLTTDYCVLVELWPKVTYHPSEYVYTQFEPGVRFRREPVSLTLALLLGGLTMGGIAARVGTGTTALVATQQFQQLQAAMHNDLKAVEESITNLERSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGLVRDSMAKLRERLNQRQKLFESGQGWFEGLFNRSPWFTTLISTIMGPLIVLLLILLFGPCILNRLVQFVKDRISVVQALILTQQYHQLKSIDPEEVESRE
What are the official names of this protein?
Retrovirus-related Env polyprotein from Fv-4 locus.
Protein: KAD_CHLPN
Sequence: MTKGSVFIIMGPPGSGKGTQSQYLANRIGLPHISTGDLLRAIIREGTPNGLKAKAYLDKGAFVPSDFVWEILKEKLQSQACSKGCIIDGFPRTLDQAHLLDSFLMDVHSNYTVIFLEISEDEILKRVCSRFLCPSCSRIYNTSQGHTECPDCHVPLIRRSDDTPEIIKERLTKYQERTAPVIAYYDSLGKLCRVSSENKEDLVFEDILKCIYK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDT5_PONAB
Sequence: MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTADGVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYKGDVAECSPAVCMDPGLSNCTVHIVTVTINGDDAENARPKPKPEFVEVISLPKNDLLQRLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF
What is the function of this protein?
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate.  In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP.  Can also hydrolyze other nucleotide sugars with low activity.  In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate.  Nuclear ATP synthesis takes place when dephosphorylated at Thr-45.  Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.  Does not play a role in U8 snoRNA decapping activity.  Binds U8 snoRNA.
What are the official names of this protein?
ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, Nuclear ATP-synthesis protein NUDIX5, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLC2_ORYSJ
Sequence: MATAFDSPTASPAASPFDDDSFLRFDAAAPAPAPADAFPPSPEPYAFRPDAPSPFGMPEANGSLHDDPFAAPDNDNGPVLPPPNQMGADEGFLLREWRRQNAILLEEKEKKEKEMRNQIILDAKEFKKAFVEKRKLNVETSKDQNREREKLYLANQEKFHAGADKQYWKAISELIPHEIANIEKRGAKKDKDKEKKPGIVVIQGPKPGKPTDMSRMRQILLKLKHTPPPHMKPPPPPAAATGKDGAAGKDGAKVAAAASKDASANGSVPEMEKAAAAAAPAAAATEPIAAA
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
What are the official names of this protein?
Clathrin light chain 2.
What is the protein family that this protein belongs to?
Belongs to the clathrin light chain family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Protein: YTFE_ECOLI
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE, Regulator of cell morphogenesis and NO signaling, RCMNS.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 2NDP_YEAST
Sequence: MYFLNQLIFQDVSVMSVDKREDMSRSFQKCLNLRYPIIQAPMAGVTTIEMAAKACIAGAIASLPLSHLDFRKVNDIEKLKLMVSQFRDQVADESLEGNLNLNFFCHDIVDKPTDLQTANWAKLYRKSMNVPIDMNEIKFDNGNVSFKAFEKENALQDFFQYLSDGFRPKIISFHFGHPSKSTIEYLQKIGILIFVTATSVREVRLLARLGINGIVCQGYEAGGHRGNFLVNDPKDDENLSTVQLVKRTVDELAEMKNKGLIHATPFVIAAGGIMDSKDISYMLSQQADAVQVGTAFLGCSESNASKNFSSPFTRETTTKMVNIISGKPARTISTPFIEKVIANFQGEELPPYGYMYSAFKQVRKKYPELANFILAGQGFQNVQSGITTDKKIETMGARLKIDGK
What is the function of this protein?
Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites.
What are the official names of this protein?
Putative nitronate monooxygenase, Nitroalkane oxidase.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family. NMO class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_CORA7
Sequence: MAIETLYDSDADLTIIQGRKVAIIGYGSQGHAHAMNLRDSGVEVAIGLREGSKSREKAEEAGFKVLTNAEAAKWADVIMLLAPDTSQAAIFTEDIEPNLEDGNALFFGHGLNIHFGLIKPAENITIGMVAPKGPGHLVRRQFVDGKGVPCLIATEQDPKGEGRELTLSYAAAIGGARAGVIPTTFKDETETDLFGEQAVLCGGVEYLIMNGFEVLTEAGYEPEMAYFEVCHELKLIVDLIVEGGIKNMNYSCSDTAEFGGYLSGPRVIDASVKERMKDVLTDIQDGTFVKRLVANVEGGNKELEDLRAKVNSHPIEQTGSQLRDLMSWVKNPLDATA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TYSY_SHESR
Sequence: MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFEDFELTNYDPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH3_CRYNJ
Sequence: MPNYYDELEIEDFAWDPVARVFHYPCPCGDRFEISKGQLRDGEEIAICPSCSLIVRVIYDYLDWEDYVTTDDEDDGGSVDTPLSNTSPDPAYPVVVGSAEVESQSKTASSAVSSQKEECTSLSDRLAGLQVESGKEDDPVQEHKREDSSDVLH
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1.  Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state.  Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM.  Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex.  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
What are the official names of this protein?
Diphthamide biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GON7_KLULA
Sequence: MSLPHATYTGPKSTHEFEVDPSDPRYQTTEGRTTGASDYVLKQGHQDVDKPSDPKKVDNVNSKTGIDQYTTLSQLRMQLTGLQDDINEYLTEKINHVKKPRNSKQEQEINDLLDGSEET
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit GON7.
What is the protein family that this protein belongs to?
Belongs to the GON7 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: HXD8_HUMAN
Sequence: MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D8, Homeobox protein Hox-4E, Homeobox protein Hox-5.4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.