PharMolix/UniProtQA huggingface dataset:
Protein: ANLN_DROME
Sequence: MDPFTQHMLEKAEQRSRALGISNASKFPLVECSVPSSSATSASGGDAGVLAPRSRSPGGQSAASGGGKVVTLGKATLEASPAKPLRHYTAVNKENLDMGIEINITTDKPIGVQVEIQEQEVTDDEEQAEGGALNPLLEAEPVNQPLARLRDTSRSRLQRMGALYSNTDDLSSPIHRTEGQFHVTTGEEEDCGNRSSRQPKQRLGKLAALADTINQWEDDTSHHEVHRLLEAPPPKPHLSSRRAEKGPAPLPPKKDEVDEASRTKQLKWDPKVLSSLEAQGFQRRESSTIKHTYDYAKQEEAAPASKVEDAVLTAKPPVPQKSTTVSQVAKNFASSAPAPKPAPAPAVSVKSGLVSGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGNNKAMLPMAPIGSAPSITQIRAEEVKQHLAAMHPVTAAAATTVVAATKPKQENKLRDKVAALVANAQSSAETRIKDIDRQRQEDMQIISNRFNKQKELFDNQPSDSSVAAQARPPAPAPSRVVRPMPPPPPPPIAALSPGLASSKRRSPGDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCCAAETASATDDSHQQDEEETESCMDESDDQSQTEDSSAGMCNGSLGREIMSAVQRNEVEMQQQQTGKKTVRYADQDMYYDDSSLNSSQVSAGIDDYLDEALVEDYGSTQDDQSDSGDEQNASRLSLGSKGTTASNSFSFRKNPASICTPIEEHHEMEMDLQTPLLSGAQPVKSELSVNQDNDNLVTLVHTVSFYRRQQSANSSNSTPVRKICREQQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIADQTDEDDEEMQNAREVNDASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLLLATHRRQACLDEVQRLRVENSIRPVGAPKEKGLLTVKDITIPLRQEYVRKMASNNINGHHLVCLLKYNEHVLATKTVPTMPGLLSVKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELKYHINLNKKGGIKTPKKKGGENRLVMPPVQSPAGPHVVRTPQLVQYGFAIFSLREIQRTTWTLTQVLGVSPLEGVVHMKVNCELSVSVEYKGFLTMFEDISGFGAWHRRWCYLNGSVINYWKYPDDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTMLLECERPALETDQESLIIVPNGRTTTVRHLLSADTKEEREEWCAYLNKALTLLRAWGTTH
What is the function of this protein?
Required for cytokinesis.  Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody.  Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei.  Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo.  Essential for embryonic viability.
What are the official names of this protein?
Anillin, Actin-binding protein 8, ABP8, Protein scraps.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody. Accumulates in the nucleus of newly divided cells in a diffuse staining pattern, thereby restarting the cycle.
Protein: MNTP_GLOC7
Sequence: MEILTTTFLSLGLAADAFAVSLTSGFSIKHIKLNKALKIALFFGCFQAIMPFIGWSAGLTFRDFISSFDHWIAFGLLSYIGGKMIYESMEEEKEDKKFNPLDSYTLTTLAIATSIDALAAGIGLSVLKGSILLACTLIGFITFGLCFIGVFIGHRFGDILNQKIEIVGGVVLILIGTKILLEHLGFSLV
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PEPT_ECO57
Sequence: MDKLLERFLNYVSLDTQSKAGVRQVPSTEGQWKLLHLLKEQLEEMGLINVTLSEKGTLMATLPANVPGDIPAIGFISHVDTSPDCSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALAVLQQKNIPHGDIRVAFTPDEEVGKGAKHFDVDAFDARWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAQRK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NMCP1_ALLCE
Sequence: MLTPQRSAWSLKSKVSSEKPRSKGKGITKNLDSAATPFPPLGLLNGGDLDRGGEDMEAWKRFKDEGLLDESICYKKDRESLASRIIELEKDLHEYQYNMGLLLIEKKEWSSHFEEMKMRLAEAEEILKREQAAHIIALTESEKREDNLRKALGVEKQCVTDLEKALREMRSEIAEVKYTAEKKMTEAFALEASIEEKRLDTERKLHSADAKLAEASRKSSEINRKLEDVEDRERKVQRELNSINSERKALEKDISEQKEHLREWEKKLQDGQNRLLDGQRHINEREERINEAEGGLKKKEEELEEAKRSIEGTRNTLKRKEEDLDVRLRSLVSKEKEIELKMKNLQKKEKDLHEIAEKLDHREREEIQKLLDEHRATLDTKKREFELELESKRKSVDEELKSKFAAVNKAEKEVNRKQGLISEGEKELESKMDKIKIKEKDLETKSKALKKWEESLKSDEKKLVAEKDQIMKDTHELKVSINELESLRDALNAEQHQIAEEREKLEISKEEREQYIQKQSELKQEIEKYRNMQEELSKGIESLREEREKFEKEWESLDEKKITLQRETKKIHEEKEKLEKWHHKDQERLRNEEANAKADIERQLEDIKLQKEAFENTMKHERLMAQEEVARRLADVTRELELRKHDLEMNMQKKQEEIERKLQGKEREFETRKEAELSRITSLINLNNSKLQKLRIEQDRLDREKEEVELQKKKLQEDQSEIQRDVDTLRQLSKNLKNQRAEFIKEKECFLAAAERCKTCQNCGVSISELEMVGIIQSSAEIENADIVLPSLTDDHIEQHMKNKGSHVTSPQTGSRVFGSGFLQKCTKIFKFSPGKNAETSATTTPLVFGEELDIAASEDAAANDNNPAADVERVTVNPSLVFGEQLDTAASEDAAANDNNPAADVERVTVNPPPLAPVATEQNETEESSLPPENDSPPKQRGGRQSTRRGRGGKTVRRTRTMEAVVDDAKAILGDTLIVEEAKESSQQNDEQSQGASVHTGGTSNTRQKRRRAPASEMTNSEHDVEESESQSQSISIGRGRRKKRQTSAASEVQAPVVERRYNLRHSTVAKNSVAATLAVSDQAKVQTKASHQASHDNNQISMGDDPALEGSHKVTHTVQKTTTASVMEVSSKPAMEETHEENIVVRSVEISEMSASEEAEGEVQGVPPIAEEPATPSSGSSTSGDIGNDDDMDDDDEEERHNASIGKKLWNFFTT
What is the function of this protein?
Architectural component of nuclear structure that plays different roles in controlling nuclear size and morphology (By similarity).  Involved in the organization of multimeric complexes in the peripheral nucleoskeleton (Probable).
What are the official names of this protein?
Nuclear matrix constituent protein 1, AcNMCP1.
What is the protein family that this protein belongs to?
Belongs to the CRWN family.
What are the subcellular locations of this protein?
Nucleus matrix. Nucleus lamina. Note=Localizes at the nuclear periphery and is associated to the nucleoskeleton.
Protein: PFKA_DICDI
Sequence: MTTTSKIINDGEGEDVKGNKNINKKSLIDENRLDEKKDLLSDKVESKTHCSVKRMAVLTSGGDSSGMNPAIRAFARQVMLKGAKVFAVREGYNGLVNDSIVPLNWGSVAGIISRGGTIIGTARSAEFRTREGRKRAVFNLVKNRIDNLLVIGGDGSLTGANLLRTEWCSLLEELVKDGKLTLDVMEHFPILSIAGIVGSIDNDMCGTDLTVGADTATKRILEAIDSILSTAVSHQRSFVIEVMGRNCGWLALASGVATGADYILIPESPPDDGWEQTMADNLERGRLSGRRCSLVIVSEGAIDRQGKPITSAYVRQFLEDKGHDARITILGHVQRGGTPTFLDRYIATRMGIEAANYFYDSTIEQLKQPVLIGMSGMDTIRSPLMECVQKTQSIASLIKERRFNEVVDVRGGMFKEFYEIFIACSNLHRRKVESKGMGVLILHSGGPSPGMNPCVRAFTRLGIDHGYTMYGCFNGFGGLALGEIEQLHWMTVNGWSVMGGAELGTNRSIPNDSNIEAIIATLERFKINAILMFGGFNGYLGIAKLYEYREKYQQLKRISIIGAPGTIANNVPGTNISIGSDTSLNNTLDALDKIKQSAVASRRLFVVEVMGAHCGYLAAMSSLTSGAERSYIMERGITLNTLTKDLEMFVERFKREHRIGLIIKSELASNTYSTHFIYSLFKEEGKHLFDVRESILGHLQQGGTPSAIDRIFSTRLMNHYYQFLENDLKEHGHLQMNGCIGFIDGGIHYTPMQEMIEEMSDKFRRPRSQWWMDLVETSQNISVFPLDDPSSTNFEGCNSNLSEQDRPIKKSDISSPTSYSQKTFDPNVNPQFTL
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_RICFE
Sequence: MANHSSAKKAARQTVKRTLINKKRSSAIKTFIKKVAHEISLGNKENANLALSVAQSKIMQGVKKNIIKLNTASRKISRLSKQIKSLNESK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CARB_STAES
Sequence: MPKRDDIKTILVVGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHDSGVLEANNVKLLGTELESIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFEFKEQVGYPLIVRPAFTMGGTGGGICHNDAELKEVVSNGLHYSPATQCLIEKSIAGYKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSLNYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLSNGESYELDYIKERIGHQDDERLFFIGEAIRRGTSLEELHNMTKIDYFFLNKFQNIIDIEHELKNHQGDLEYLKYAKDYGFSDKVIAHRWDKEEKDIYQLRMSQNIKPVYKMVDTCAAEFESTTPYYYGTYEYENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQNAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEQPKGVVVQFGGQTAINLADKLAQHGVKILGTSLEDLNRAEDRKEFEALLREIAVPQPQGKTATSPKEALENAREIGYPVVVRPSYVLGGRAMEIVDNDQELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAISDGETVVIPGIMEHIERAGVHSGDSIAVYPPQTLTQDEINTLEDYTIKLAKGLNIKGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIQMAQLAMRAIMGETLAEIGFKQGIQPYSEGVYVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDLTLEKALYKGLTGSGFEVKDHGTVLMTVSDKDKDEIVKIAHRLNEIGYKILATRGTAQKLKDHNIPVEVVGKIGGEDDLLTRIQNGEVQIVINTMTKGKEIERDGFQIRRTTVENGVPCLTSLDTASALTNVIESMTFTMRNV
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: LSPA_STAAB
Sequence: MHKKYFIGTSILIAVFVVIFDQVTKYIIATTMKIGDSFEVIPHFLNITSHRNNGAAWGILSGKMTFFFIITIIILIALVYFFINDAQYNLFMQVAISLLFAGALGNFIDRVLTGEVVDFIDTNIFGYDFPIFNIADSSLTIGVILIIIALLKDTSNKKEKEVK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: JAL8_ARATH
Sequence: MFIIYLFIFLSSAIIDSNGVAMAQKIEAIGGKGGKRWDDGANDNVAKVYIRGDHEGIQYIKFDYVKDGQSFNGSVHGVSADGFTQTFEIDHLQYEQIVSVEGYYDWKTGVMQALQFKTNLKTSEFIGYQKGTKFSLGVDGKVIVGFHGSAWRSLRSLGAYVKTAPTKSELQGGITGGEYWDDGPNFDGVRKVYVTFTETHIRSMNIDYDQDGQVVTRYHGMKNGETQEFAVDFPNEYMTSVEGTYDHISEGNYLVLTSLTFKTSKGRISQTFGLVIGTKFVLETKGNVISGFHGRDGGSFDAIGVYFSPMISS
What are the official names of this protein?
Jacalin-related lectin 8.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.
Protein: PUR9_RUEPO
Sequence: MTDLSPVRRALLSVSDKTGLIELGQALAARGVELLSTGGTAKALRDAGLTVRDVAEVTGFPEMMDGRVKTLHPMVHGGLLALRDNADHVAAMEQHGIAGIDLLVVNLYPFEATVAKGADYDDCIENIDIGGPAMIRAASKNHAFVNVVVDVADYDALLAEMAANDGQTSYAFRQRLAQTAYARTAAYDAAVSNWMADQLALEAPRRRAFAGELKQTLRYGENSHQQAAFYTDGSNRPGVATARQLQGKELSYNNINDTDAAFELVAEFAPENGPACAIIKHANPCGVALGATLSEAYQKAFDCDRTSAFGGIVALNQPLDAETAGKIVEIFTEVVIAPGASDEAIAIFATKKNLRLLLTDGLPDPRQPIVAMKQVAGGLLVQDKDVGHVDLTDLKVVTRKAPTEAQMADLLFAWKVGKHVKSNAIVYVKDGATVGVGAGQMSRLDSANVAAAKAQRMATELGLPESPAKGCAVASDAFFPFADGLLEAAAAGGACVIQPGGSMRDDEVIKAADEAGLAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: GSDM_BRATP
Sequence: MNCSRDTGDELMAALLAEGINLILPPRDNIAPGDLIIADPQGGARLGGWHEVFNLQLSPEVATDPGFKSFQFRASSILQVGVAASVMGRVLQALGLGSGSFSSAFSSSNADTIQLSIVAPANKELTNFDAVLVQMNEAKAEPAQGYTDRNFFVVTKVWRARGIRISVADKSKKQVDLSAKAVEELTAKAKMELKREDTGSYAFLAASQLIFGLTLREVTYKDGAIVDVAPTGPLKFRGKGPGDPFAFIGDDAFVDLPES
What is the function of this protein?
Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity.  Makes ring-like pores when released.
What are the official names of this protein?
Gasdermin bGSDM, bGSDM, Bacterial gasdermin.
What is the protein family that this protein belongs to?
Belongs to the bacterial gasdermin family.
What are the subcellular locations of this protein?
[Gasdermin bGSDM]: Cytoplasm. SUBCELLULAR LOCATION: [Gasdermin bGSDM, N-terminus]: Cell inner membrane; Multi-pass membrane protein.
Protein: PG064_VACCC
Sequence: MISVTDIRRAFLDNECHTITKAFGYLHEDNAIALIKIGFHPTYLPKVLYNNVVEFVPEKLYLFKPRTVAPLDLISTITKLKNVDKFASHINYHKNSILITGDKSLIVKCMPYMIISDDDIRFIREQFVGTNSIEYILSFINKESIYRMSYQFSENEIVTIINRDHFMYEPIYEHQVLDSDFLKTMLDRYGIVPINSGIIDELCPEAIIEILMAVVRPRDAIRFLDIVNKNQLTEDSVKNYIINDIRRGKIDYYIPYVEDFLEDRTEDLGIYANIFFEDAIDITKLDITKTELEHISKYMNYYTTYIDHIVNIILQNNYIDILASIIDYVQDVLTEELCIRIVCESTNPVPVTSLPIHSTLVMVMCIQMKYVDIVEFLDEIDIDTLIEKGADPITEYTFTTRWYNKHNDLITLYIKKYGFCPMMMKRLMFEYPLTKEASDHLLKTMDENRGAIMFFPRTICTLPYLLCCNYKLIQKPIPFKEENRNIVYKKNNRVLCFDSLENSAFKSLIKIDSIPGLKTYNMKDITYEKSNNIICVRFIPQESIHNEERRIKLQLFDIARLASYGLYYIPSRYLSSWTPVVNMIEGREYTNPQKIECLVILDLFSEEFIEYQNLGNAVSNKYELEYTISNYQAAINCLMSTLLIYLVLGSIRSISKTEDFVLSILNIFYKGLKINELLSEPVSGVCIELNKIKDRASSGDSSFIFLKKNELSKTLSLCEKVCVETILDNNQSFKSSK
What is the function of this protein?
Plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules.  Together with protein OPG056, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.
What are the official names of this protein?
Protein OPG064, Protein E2.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG064 family.
Protein: CAR11_HUMAN
Sequence: MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQRKTIWVDEDQL
What is the function of this protein?
Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734).  Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195).  Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955).  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).  Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308).  Stimulates the phosphorylation of BCL10 (PubMed:11356195).  Also activates the TORC1 signaling pathway (PubMed:28628108).
What are the official names of this protein?
Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1.
What are the subcellular locations of this protein?
Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Protein: SSB_WOLSU
Sequence: MYNKVILVGNLTRDVELRYLPSGSALAKIGIATNRRFKKQDGSQGDEVCFVDVNLFGRTAEIANQYLKKGSKILIEGRLVLESWTDQSGQKRSKHSVTAESLQMLDSKGASQGGYEGEDYSSYDSTPSYGATSSAKSAPNTQAPYKEPQIPEINIDDDEIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: KMO_DANRE
Sequence: METAFSHPPQSSSSKRKVIAVVGGGLVGSLNACFLAKRGFDVEVYESREDIRQAKVVKGRSINLALSHRGRQALKHVGMEDKIISKGIPMHARMIHNVNGKRSPIPYGKKGQYILSVDRANLNKELLTAAEAYPNTRLNFNHKLHDWSPKTGTMTFIGSDGQKTETQADLIVGCDGAFSAVRKQFLRQSRFNYSQTYIPHGYMELTMPPKDGDFAMEPNYLHIWPRNTFMMIALPNLDRTFTCTLFMPFEDFEKIRTGDELLRFFHKYFPDSVPLIGVEALKQDFFRLPAQAMVSVKCCPYHLFEKCVLMGDAAHAVVPFYGQGMNAGFEDCLVFDEIMDQFNENLVAVLQEYTRVRVPDDHAIADLAMYNYIEMRAHVNSKYFIFRKYLDNLLHFFMPKTIVPLYTMVTFTRTRYNDAVNRWHWQNKVITRGLWLCGFVSAAGGTYVLVKNSHKLPSISAEQLWTRILALKLF
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: GOG6C_HUMAN
Sequence: MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQELGAAGEQDDFYEVSLDNNVEPAPGAAREGSPHDNPPVQQIVQLSPVMQDT
What are the official names of this protein?
Golgin subfamily A member 6C.
What is the protein family that this protein belongs to?
Belongs to the GOLGA6 family.
Protein: YH5B_SCHPO
Sequence: MSKTAASSAVDASQAGTVKVGDMVVNRMGFGAMRVTGDGIWDEPKDKEACIATLKRLPELNINFIDTADSYGPEVSENLLREALYPYKGLIIATKGGLVRTGPNEWHPCGAPKFLRQEVLMSMRRLGVKQIDLWQLHRIDPKVPRKDQFSEIAAMKKEGLIRHVGLSEVTVDDIKEAEQYFPVVSVQNLFNLVNRKNEKVLEYCEQKGIAFIPWYPLASGALAKPGTILDAVSKDLDRSTSQIALSWVLQRSPVMLPIPGTSKVDHLEENVKAAGIQLSSEVFAKLDEEGKSEDAKRQEEEKKKSS
What are the official names of this protein?
Uncharacterized oxidoreductase C215.11c.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ACDH1_PSEP1
Sequence: MTRKVKAAIIGSGNIGTDLMIKILRHGQHIEMGAMVGIDPASDGLARAQRMGVAITHEGVEGLTRLPVFNEIDVVFDATSAGAHVKNEALLRERKPGLRMIDLTPAAIGPYCIPVVNGDDHLDATNVNMVTCGGQATIPMVAAVSRVAKVHYAEIIASISSKSAGPGTRANIDEFTETTSKAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYTLSDFADIDQIEESVQRMADAVQAYVPGYRLKQRVQFDRIEADCPIRIPGVGDRMNGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAALRTAEKLAERLLASLVA
What are the official names of this protein?
Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase [acetylating] 1.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: HTPX_STRA5
Sequence: MLYQQIASNKRKTVVLLIVFFCLLAAIGAAVGYLVLGSYQFGLVLALIIGVIYAVSMIFQSTNVVMSMNNAREVTEDEAPNYFHIVEDMAMIAQIPMPRVFIVEDDSLNAFATGSKPENAAVAATTGLLAVMNREELEGVIGHEVSHIRNYDIRISTIAVALASAVTLISSIGSRMLFYGGGRRRDDDREDGGNILVLIFSILSLILAPLAASLVQLAISRQREYLADASSVELTRNPQGMISALEKLDRSEPMGHPVDDASAALYINDPTKKEGLKSLFYTHPPIADRIERLRHM
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y4497_PSEPG
Sequence: MPSFDVVSELDKHEVQNAVDNAIKELDRRYDLKGKGSFEFKDKDQTVMLTAEEEFQLEAMLEILRLALVKRKIDVKCLETKDPYPSGKEKKQEAKFREGIDKDLAKKIVATIKDGKLKVQAAIQGEQVRVTGKKRDDLQEAIALLRTKEFDMPLQFNNFRD
What are the official names of this protein?
UPF0234 protein PputGB1_4497.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RS13_DESAL
Sequence: MARIAGVDLPKRKRIEIGLTYIFGIGRSTSSKILEELGIDPDTKTDDLTEGQVNDIRKLIDSKYRVEGELRTQISMNIKRLMDLGCYRGLRHRRGLPVHGQRTSTNARTRKGPRRAAVKKKGGAKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: K2C1_XENLA
Sequence: FLEQQNKVLETKWKLLQEQGTKGTTKRANLDPLFEKYIADLKKYLDNLISEKGRLQQELKNLQLLVEDYKKKYEDEINKRTKAENDFVLLKKDVDAAYMVKTELEAKVDTLTSEINFLRTRDAAELSQVHDQVTDTSVVLTMDNNRDLNLDSIIKEVKCQYEQIAQRSKLEAEALYDQKYKQLQQTVEGHGDSIKNSKTEISDLNRKIQRLKAEIENVKKQIASLNQSIAGAEERGNLSLKDAEKKLKDLEDAERKLKADMARQLKEYQELMSAKLALNLEISTYRYMLEGEEGRISGQIVNKVSISVLSGGSSVYTALGGAAGGMGGGGGGGMGSGHGGGYGGMVFGGGMGCGMGDGMGGGGMGGGMGSGHGGGYGHGGAVCFGAGGMGYEGGSMHGGGSSYGHSGGKTSVAIASTTSTTKKTY
What are the official names of this protein?
Keratin, type II cytoskeletal I, Clone PUF23.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: PURA_CYTH3
Sequence: MAVDVLLGLQWGDEGKGKVVDVLAPKYDYVARFQGGPNAGHTLIFDGHKVVLHQIPSGVFRSNITNLIGNGLVLDVIALFEKEIDKLEAFKLNLNKNLFISKKAALILPSHVELDKAYEAAKGAGKIGSTLRGIGPTYTDKVSRHGLRVGDILSPDFMDKYNKLVDQHKQILDFHKHDYSEMKEREDLFFKYIDRLRKMNLVDSEYFINDAIQSKKTILAEGAQGSLLDIDFGSYPFVTSSSTMVAGACTGLGIAPKHIGNVFGIFKAYCTRVGSGPFPTELHDAVGEEIRKQGNEFGSTTGRPRRCGWLDLPALKYACMINGVSHLLMMKADVLNAFEELQVCTHYKLGNGDIVDTLPYDMCTNDLTPVYKTLKGWNQDLSNCETFDSLPQALLDYSAFIEAELGLPITLISIGPDRKETLIKDFSFITA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.