PharMolix/UniProtQA huggingface dataset:
Protein: ISPH_BLOPB
Sequence: MKVVLASPRGFCAGVNRAINIVEKTIQVYGTPIYVRHELVHNDYVVTQLSKKGVIFIERLNEVPNGSVLIFSAHGVSKKIQEQSKIKNLIIIDATCPLVTKVHKEVSRANRNDMEVILIGHSGHPEVEGTMGQYISVNSRQKIYLVESQADAWSVQVNQPNHLFFVTQTTLSIDDTAEIIAILNKRFPNIMGPRKNDICYATFNRQNALKNLAPMVEMIFVVGSITSSNSVRLMELGRRIGKITYLISHANDIQKNWLRGVNNIGITAGASAPDILVLQVIEKLRVLSTDHVVVEEMIGEEENIFFDTPKI
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: YNFA_ECO27
Sequence: MIKTTLLFFATALCEIIGCFLPWLWLKRNASIWLLLPAGISLALFVWLLTLHPAASGRVYAAYGGVYVCTALIWLRVVDGVKLTLYDWTGALIALCGMLIIVAGWGRT
What are the official names of this protein?
UPF0060 membrane protein YnfA.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADD_PORG3
Sequence: MLTGLFFGSFNPMHIGHLALANYLTEYTPIRQLWFVPSPLNPLKNTQELLPYDLRCELIEQAIRKDIRFQVLRIEELLPSPHYTIRTLRALSMLYPHHRFALLIGADNWQSFDRWKDHHRLMAKYELIIYPRFGYEVNDTTLPTGCRYIHDAPRIEISSTQIRTSILEGKDLRYWLPLPESQDVIASALQSCLSPKR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: RL20_ORITI
Sequence: MSRARSGKVNKNRHKKILKLAKGYRGRAKNCFRIAIQKVEKALQYSYRDRRNRKRQFRALWIQRINAAVRQYDITYSQFINGLKQANITVDRKVMADLAVHNADSFVHLVELTKKSLAKTA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PA2A2_MACLB
Sequence: MRTLWIVAVWLTGVEGDLSQFGDMINKKTGTFGLFSYIYYGCYCGWGGKGKPQDATDRCCFVHDCCYGSVNGCDPKLSTYSYSFQNGDIVCGDDDPCLRAVCECDRVAAICSGENMNTYDKKYMLYSLFDCKEESEKC
What is the function of this protein?
Snake venom phospholipase that inhibits ADP- and collagen-induced human platelet aggregation.  This inhibition is completely inhibited by abolition of catalytic activity in case of collagen as inducer and partially inhibited in case of ADP as inducer.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 2, Vl-PLA2-2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y310_BUCAP
Sequence: MQQIYKIIFLSFNQDFFYKTIKILINIILIVIFILLSSCNFLTDKKAFFLNKEFSQKEKEFKRLKEKKEYLKKHTIHKHIFSYGNTISIFLKKSGVKINDILKLIKIDKNLNNITIGQKIVCKVDNLGNLIKLKWYISKFQKKIYKRYKNTFKFIKYTYDSFLEKKSIYIKKNSNFFKSAYQSGLNKSEINSVIKAIEWQINFNKLHIGSKFNVIFLNQKTKNKKILLGVKLDNLDRKYFSIRAFNGKFYDSDGFNKSEELINFSFLKKYRISSPFNLRRVNPVTHRISRHLGIDLAMPQGTPVIATSSGKIIKAQFNKIAGFYISLKNKNYYTTRYMHLKKILVKVGQKIKKGEKIALSGNTGRTTGPHLHYEIWINHRAINPIKAEYILSTQLTKSERIKYLKESKNILSKLK
What are the official names of this protein?
Uncharacterized metalloprotease BUsg_310.
What is the protein family that this protein belongs to?
Belongs to the peptidase M23B family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PSBL_COECR
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ERPA_STRM5
Sequence: MSTLVSLPGATPVAAPDYQSLERPLNFTESAAAKVKSLIQEEGNLDLALRVYIEGGGCSGFQYGFEFDENRAEDDLAVQTSGVTLLVDPLSLQYLMGAEVDYTESLTGAQFVIRNPNAKTTCGCGSSFSM
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: IDI2_VIBPA
Sequence: MAPQTNRKDLHLDAVLHHDMSMKKKTAGFESVEFEHCALPECDFNTIDLSTEFLGHRLALPFLISSMTGGARDAETINCRLAEAASELGIAMGVGSQRISLEESQHSGLGKTIRELAKGVPLYSNLGAAQLRDKGKLDNAQRAVEAIQADALFVHVNPMQEAFQKNGDHNWIGVLHAIEQLKPRVNVPIIIKEVGFGISGDVAQRLVDAGVDAIDVAGAGGTSWSAVEGYCQDNPHMQRAAELFRDWGIPTATCLAQIRAQHPKLPLIASGGIHNGLEAAKAIHLGANLVGQAGAVLKAATISTQLVVDHFEQMALELRLACFGTGSAKVNALTKARRL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_BACC2
Sequence: MRILGLDVGTKTVGVAMSDEMGWTAQGLETIKINEERGHFGFDRISELVKQYNVDKIVVGLPKNMNGTIGPRGEACQQFAENLRELLQLDVVMWDERLSTMAAERLLISADVSRKKRKQVIDKMAAVVILQGFLDSK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_RUTMC
Sequence: MKSKKQTKLLLILDGWGYSETIQNNAIALANTPVWDKLNQTFLHSLIHTSGKDVGLPGKQMGNSEVGHLNLGAGRIVKQDFTRIYNELQNGDFFRNPILKNSLEYANDNNKAVHIMGLLSDGGVHSHEEQIHAMLEMTHKQGCKNVYLHLFTDGRDCAQKSAEKYIQKFEEKMAILGTGEIVSIIGRYFSMDRDNRWSRIRCAYELIAKGKAKFLAQSALHAVELAYARGETDEFIQSTSIKIPISIKKGDVLIFMNYRADRARQITRAFTDENLQGFSRGTFVPTQFICLTEYKKDFNLPVAYPSSKLNNVLGKYLSNLGMTQLRIAETEKYAHVTFFLNGGVEQAFNGEDRILIPSPDVATYDLQPEMSAFELTDALIESIESQKYDLIICNFANTDMVGHSGKLNATIKAVETIDSCLGIIHKAMFAISGEILITADHGNAEQMINPKTHEVHTAHTNNPVPLIFVSERKADISEPEKGALSDIAPTLLAMMDIEKPNEMTGNSLLTFK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: ANM7_ORYSJ
Sequence: MPSCCCLLGLGFPSPPSALRILRRRMASRAFQLRLNPLTGDSEWLVVEEEEEEDHHPTPPPKQLLATTSYLDMLNDSARNRAYRRAIEAAVTDPSSRVLDIGAGTGLLSMMAARALAAVGGETRGGSVSACESYLPMGKLMRRVLRANGMENRVKVFHKRSDELKVRDDLDSPADILVSEILDSELLGEGLIPTLQQAYDMLLAKNPKIVPYRATTYGQLVESTFLWKLHDLHNNEANAADGVWLTPGEMERIVSVKPQQHAMQCDALEDEIRLLSEPFKVFEFDFWKRPDSHREANIKIRTTRDGYVHAIISWWVLQLDSAGSIFYSTAPRWARQSSSEGPQRDMKDWCDHWKQCVWFMQGKGIPATEDQVLSLRARHNQTSISYQLNINDEACDRSSKGDHLTLLPERIALYGDKDWRSALINTIKNALTVKSSPTCVVADDSMFLALLISSMSPTSKVIAMYPGLRDKGAAYLRSVADANNFSIDQIQVIGKRASSITADDLKHKKVNLLVGEPFYLGSEGMLPWQNLRFWSVRTLLDSMLSEDAFIMPCKGILKLCAMSLPDLWRSRSSLKDVEGFDHSVVNETLGACGCLPGDQQGPCLPYYVWQCGYTKKLSKVYSLMDFNFSEPIHSCFGKTKIEFSHDGTCHGFAVWIDWVLDERKSVVLTTGPDNRYWKQGVQLFSKPVEVNPGKSVMHVEASFDPSTGEITFSSSSTTCS
What is the function of this protein?
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
What are the official names of this protein?
Protein arginine N-methyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
Protein: CAS1A_PYRAE
Sequence: MEVVVKDWGVSLGYSRGALVIKKRGGVDRIPLFQVDRIWILTGGVSISSRLVRALSHHFIDVVFFDAKGNPVARLFPPEANGTVTHRRAQYEAYLTGRGFELAKLVTYGKLINQARALRRLGQWKREHYGALAEAASKIADLAGRIPSCADVQCVLGHEGAAASLYWDAVSKTTGLPGRNPEAADPLNLALNYGYGVLKYAVWRQAVIHGLDPYAGYIHADKSGRPSLVLDLMEEFRPHVDLLVIRLRPSADWADGGVLKREIRAMLVEEWTGERLEPVIARQVGLAVAHLHGQRAYTPHQL
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: BVGA_BORBR
Sequence: MYNKVLIIDDHPVLRFAVRVLMEKEGFEVIGETDNGIDGLKIAREKIPNLVVLDIGIPKLDGLEVIARLQSLGLPLRVLVLTGQPPSLFARRCLNSGAAGFVCKHENLHEVINAAKAVMAGYTYFPSTTLSEMRMGDNAKSDSTLISVLSNRELTVLQLLAQGMSNKDIADSMFLSNKTVSTYKTRLLQKLNATSLVELIDLAKRNNLA
What is the function of this protein?
Member of the two-component regulatory system BvgS/BvgA.  Activates the transcription of virulence genes.
What are the official names of this protein?
Virulence factors putative positive transcription regulator BvgA.
Protein: SH3K1_HUMAN
Sequence: MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
What is the function of this protein?
Adapter protein involved in regulating diverse signal transduction pathways.  Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins.  The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2.  Involved in regulation of ligand-dependent endocytosis of the IgE receptor.  Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity).  May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP.  May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4.  Is involved in modulation of tumor necrosis factor mediated apoptosis.  Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the control of cell shape and migration.  Has an essential role in the stimulation of B cell activation (PubMed:29636373).
What are the official names of this protein?
SH3 domain-containing kinase-binding protein 1, CD2-binding protein 3, CD2BP3, Cbl-interacting protein of 85 kDa, Human Src family kinase-binding protein 1, HSB-1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403).
Protein: PYRD_SALHS
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPLEALVRQKVPTKPVTCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHFDGILGINIGKNKDTPVENGKDDYLICMEKVYAYAGYIAINISSPNTPGLRTLQYGDALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAPDLCEEELIQVADSLLRHNIDGVIATNTTLDRSLVQGMKNCQQTGGLSGRPLQLKSTEIIRRLSQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GSTT1_DROTE
Sequence: GSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFVKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQEYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNKWYENAKKVTPGWEENWAGCLEFKKYF
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Has DDT dehydrochlorinase activity (By similarity).
What are the official names of this protein?
Glutathione S-transferase 1-1, DDT-dehydrochlorinase, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: CLU1O_HUMAN
Sequence: MNKLGHNELKECLKTATDSLQTVQPSISQTCTSYGPALGAPLPGRNEVALLTSLPPNYEISEGKPRAISAYVRAGKGNVTRRRKKTHLGNDDGKKEAQEKM
What are the official names of this protein?
Putative uncharacterized protein CLLU1-AS1, CLLU1 antisense RNA 1, Chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.
Protein: AROQ_STRCO
Sequence: MPRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAGAGSARA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: LEXA_TERTT
Sequence: MIKLTARQQQILDLIRDHIAETGYPPTRAEIAEILGFKSANAAEEHLKALARKGAIEMIAGASRGIRLPEVQSGIPLVGRVAAGSPILAQEHIEDYCDIPHNFFSPKADFLLTVHGMSMKDIGILDGDLLAVHKTDQVRNGDIVVARIDNEVTVKRFKRERNRAQVELWPENPDFNVIEVDLRDANFAIEGLSVGVIRRS
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SYDND_LARHH
Sequence: MRTDYCGLIDTRYLDQTVTVKGWVHRRRDHGGVIFIDLRDREGLVQVVIDPDTPEAFATADSARNEFVLSITGRVRRRPEGTTNAKMISGEIELLAKEIEILNAAATPPFQIDDENLSETVRLTNRVIDLRRPAMQKNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRSTPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVAGFDRYYQIVKCFRDEDLRADRQPEFTQIDLETSFLNEDDIMDITEGMARQVFHDAMDVELGDFPRMTYADAMHYYGSDKPDLRVSLKFAELTDVMKDVPFKVFNAAANLPNGRVVALRVPGGAKLSRKEIDEYTQFVGIYGAKGLAYIKVNDVSKLTTDETSGLQSPIVKNLTEGVLKSIVERTGAENGDIIFFGADKAKVVNEAIGALRIRIGHEHGEAGGYFVREWRPLWVVDFPMFEYDEDDDRWTACHHPFTSPKPGHEDLMATDPGACIARAYDMVLNGWEIGGGSIRIHRADVQEKVFGALKISPEEQQNKFGFLLDNLKFGAPPHGGLAFGLDRLVTLMAGADSIRDVIAFPKTQRAQCLLTNAPNAVDEKQLKELSLRLRQKADVAGGAA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_CORA7
Sequence: MTIGKILLYYCFTPIEDPTAIMLWQRSLCEKLGLKGRILISEHGINGTVGGDMDACKRYVRETREYPGFKKMEFKWSEGGAEDFPRLSVKVRDEIVAFGAPGELKVDENGVIGGGVHLKPEEVNKLVEERGEEVVFFDGRNAMEAEIGKFKNAVVPDVRTTHDFIAELESGKYDWMKDKPVVSYCTGGIRCEILSALMKNRGFNEVYQIDGGIVRYGEKYGNDGLWEGSMYVFDKRMHHEFGQGLEDPGFIQLGHCVHCGKGTNTFHNCINEDTCRKQVLICDDCIQHVETQHCGRPDCAEVAASQAQA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: GRPE_ECODH
Sequence: MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKVANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCPD_HELPJ
Sequence: MIKSWTKKWFLILFLMASCFGHLVATTGEKYFKMANQALKRGDYHRAVAFYKRSCNLRMGVGCTSLGSMYEYGDGVDQNISKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKDFPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSFSKYACSLNYGISCNFVGYMYKSAKGVEKDLKKALANFKRGCHLKDGASCVSLGYLYEAGMDVKQNEEQALNLYKKGCSLKEGSGCHNVAVMYYTGKGAPKDLEKATSYYKKGCALGFSGSCKVLEVIGKESDNLQDDAQNDTQDSVQ
What is the function of this protein?
May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.  Binds to penicillin (By similarity).
What are the official names of this protein?
Putative beta-lactamase HcpD, Cysteine-rich protein D, Penicillin-binding protein 4, PBP 4.
What is the protein family that this protein belongs to?
Belongs to the hcp beta-lactamase family.
What are the subcellular locations of this protein?
Secreted.
Protein: LUCB_OPLGR
Sequence: MAVNFKFSLLTITIVVNILVYCNASAIKFDVDLEKVPSNAVACPAAEDIAPCTCKVGEGDVMDMDCSKVTSDAELASIFSKTFPSNTFRELFIEFNREITTLTADSLGAATFTKIAITSCTQLKTIEENAFMASAATLEKLVLLKNDLSSFPFEEMSQYTKLNWLELSVNSITGWPALSSDTLANLILFRNPIGNIPVDAFQTLPNIEQFNCFDCSITEVEAGTFTRSPKLQKLVLGYNGLTSLPVGAIKLHGHGPTTSNLGITNNQIISFPEGAVEGIQGILGIDFNRVTSLSEEVWRPILENLFQFSLLNNPLACVCDVMWLIDSPELLAKIKGNPRCAGGKRLKNLDPAVFHAMCQ
What is the function of this protein?
Non-catalytic subunit of oplophorus-luciferin 2-monooxygenase.  May stabilize the active conformation of the catalytic subunit.
What are the official names of this protein?
Oplophorus-luciferin 2-monooxygenase non-catalytic subunit.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPG_ECO5E
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RDRP_MPRVN
Sequence: MSRKLGSNAPTPMHLRLGNRYETIEQLFNKTRDINRPNKQQDVEIANTQETQWMHACKLALDLATEEQFERAVSIVKEWSIEDRKHDNPTESSYFPVIIRSSKEAEFPFKERSAVLTQYGMDALLEARLNDPSGKRGVDAEESKLGFINIETMNVKINGDYVTVNGVDLPKWSADNDASAKVGVTCSEAWFGARDARWTEACRHLPFSLASTYVTWLMLLTEQAAGNDKFNIDGHGFTNLLTGLIYLASEWATRTSKSRLKKNVDIKGRVLLESWIKGNPPAIPSWMDDWGKPMKYKYVTESDVGIKPHNDKGLAEWSKEAQLRNTPEGADTESLLRSRIPFTEADSGPPYITDSALTTSGPLRAFLCYSTAVECCGSIHLRGFTEYYKCVLHYLGTQPGKIGKQISKVSSPVARALGATSKEVMVPRRVQPSEHVWCDETDCVTVKFEDNYVLQLMCASYDIPTNWESLENKMFENELMGHCLRHIYDEYKHEHVNIHNSDLFDVITHLTNAGSAEGYVRSCLATLPVDGYMSHMKRIALEGIDSSEDKEVSQYERVHWDAIMRTILPPTPEGAVQELKALSNSRSGGADRIRFKSDRNTALANSDRETDAPFVMSSNRKNSTIAMAAHLILNPVTLKHRSSYEVPLPTGIRSVPARILRLIYNMPLPMQSLLQPLYKAMKAYMKRPTHNERYQLALNKGVVVHDSRTLINNSINCVHNPRLVSIADDASKLDQHEGPRARNVLIDALEAIPIDNGFADEFGDSYTDLMRNMLAGWNTNYFAFNVDAEQKQVMSVDTDPSGALITAEKNTVTSAGIQDMIIARTNIPQRDYLWGDDAYAMLTIPDDRNIVELIREREVIATDAGQVMDTLNGSWSGRGVHFLQVYTLWGQRMKRRTAIDHENPARYSMGDSGSLLTKYVMMGTRGGGIQMTNMLILSTIIQASRFKVFGRQFFLPFPTIAAPGGHVNMILTGFPAPNSKLWLSTNYHHIMPQHVKDRGVIKRPAVDQPEHIGARLLSEKDTLEVKVTIGGAVAQDAEGNLPTAGDLMKRAHRKLREQTRHDLYKKNKHKFLNWALTADVDLGDYSKLAYSRSTQGAAEKAIGTQTAEKHLKKWFDEKAMVRAGLISVARGAADAPIPEETESLLLNDTMHVGKVRIAWRFDNDIYLKFKHDEKHNILLFNKAMNPVKEYKYRWHPFWSQPKCMKMLLAYTGVHARPNVLTIKDLTAKFSPHRFRADLHAEDIMGLLKKVPTHMQAQALSFVGFDSHEIEEMQKHIPKIHLYEDLSELDDYSGMDDSVKCAELDRITEFLQMVMSDATYGILDDPESPELRSAVHVQFVSLLADEFNVSYACACSNEIRIRLPIPELSYDV
What is the function of this protein?
RNA-directed RNA polymerase that is involved in transcription and genome replication.  Following infection, it catalyzes the synthesis of fully conservative plus strands.  After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase VP2.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion.