PharMolix/UniProtQA huggingface dataset:
Protein: MPP9_HUMAN
Sequence: MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL
What is the function of this protein?
Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385).  At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385).
What are the official names of this protein?
M-phase phosphoprotein 9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (PubMed:21399614). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (PubMed:30375385).
Protein: ISPDF_WOLTR
Sequence: MTLADKPVLSHAVKKLLTNQYIDYVRVIINRNHEDFYRETIDSLHNYYLSEAVHSFQYVTLKSRKKEEWIPVSSTGMKGRVDTKLLSPVYGGKSRQNSVKLGLESLQKINPDFVVIHDACRPFVSNTLINNLARSMINNQHTGVVPAIEVEDTISLVNDDLIESTIPRERLRAIQTPQIFNFKELLSYHRSNKEFTDDSSLMVEHKKRVVVTRGEKINFKLTTKEDINMAKLLLDEPKYRVGTGYDIHRFIKAQGKAKSFIKICGVEIEYDMKIEAHSDGDVAIHAVVDAILGALGCGDIGAHFPPSFPEWKDRNSSHFLDFAAKKAKEKGYSVSNLDITIVCEEPKISPYKVAMKKFISKTLEIDSEFVNVKATTTEKLGSIGRNEGILAHASVLLYKIAPLHN
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: ALLC_PSEFS
Sequence: MKAYAAPFEKFVNLADARLGTKIISVTDDWFADANRLFQPTPAVWKEGVFDDNGKWMDGWESRRKRFEGYDSAVIRLGVPGSIKGVDIDTSFFTGNYPPSASLEACFLASGEPDETTQWVEVLSAVELQGNSHHYHEINNDQAFSHLRFNIYPDGGVARLRVYGVPFRDWSSVGDNEQVDLAAALNGGRALACSDEHFGRMSNILNPGRGVNMGDGWETARRRTPGNDWVIVALGHPGEIEKIIVDTLHFKGNYPDTCSIQGAFVKGGTDSQIETQSLFWRELLPAQKLEMHAEHTFAEQIKALGPITHIRLNVFPDGGVSRLRVLGKVSK
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: AHL3_ARATH
Sequence: MEEREGTNINNNITSSFGLKQQHEAAASDGGYSMDPPPRPENPNPFLVPPTTVPAAATVAAAVTENAATPFSLTMPTENTSAEQLKKKRGRPRKYNPDGTLVVTLSPMPISSSVPLTSEFPPRKRGRGRGKSNRWLKKSQMFQFDRSPVDTNLAGVGTADFVGANFTPHVLIVNAGEDVTMKIMTFSQQGSRAICILSANGPISNVTLRQSMTSGGTLTYEGRFEILSLTGSFMQNDSGGTRSRAGGMSVCLAGPDGRVFGGGLAGLFLAAGPVQVMVGTFIAGQEQSQLELAKERRLRFGAQPSSISFNISAEERKARFERLNKSVAIPAPTTSYTHVNTTNAVHSYYTNSVNHVKDPFSSIPVGGGGGGEVGEEEGEEDDDELEGEDEEFGGDSQSDNEIPS
What is the function of this protein?
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity).  Acts redundantly with AHL4 to regulate the formation of tissue boundary between the xylem and procambium in the root meristem (PubMed:23335615).
What are the official names of this protein?
AT-hook motif nuclear-localized protein 3.
Protein: YVCJ_BACSU
Sequence: MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSLLPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDSILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIVKHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSSYVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYFKKDYYTHVTHRDIEKRSRK
What is the function of this protein?
Displays ATPase and GTPase activities.  Can also hydrolyze pNPP.  May affect the expression of competence via the phosphorylation of a cellular component.
What are the official names of this protein?
Nucleotide-binding protein YvcJ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: SCPB_LACLS
Sequence: MNKTATCELLLFVSGEAGLTLTELSSLTEMSKQACQQQIDYLKEKYHSDRESALTIIETAGKYRMATKEDFSEILKNYAKTPLNQSLSKSALEVLSIIAYKQPLTRIEIDQLRGVNSSGVLSTLRAFDLVEKVGQVEAPGRPSLYATTEFFLDYIGINNLEELPEIDESRYVAEQQTLFNESEENENQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: AROC_LISMC
Sequence: MRYLTAGESHGPGLTTIIEGLPAGMPLLAEDVNKELKRRQGGHGRGARMRIEKDQVQITAGIRHGKTLGAPVAMFVENKDWKHWETVMSIEPVPEKNEKSRRVSRPRPGHADLVGGMKYGHNDMRNVLERSSARETTVRVAAGAVAKKLLHELGIEVAGHVLEIGGTRANLTRDYAVREIQETSEASPVRCLDGVAAEEMMQKIDDAKKNGDTIGGIVEVVVGGVPAGLGSYVQWDKKLDAKIARAIVSINAFKGAEFGVGFEAARKPGSEVMDEILWSKEDGYTRRTNNLGGFEGGMTNGMPIVVRGVMKPIPTLYKPLQSVDIDSKETFNASVERSDSCAVPAASVVAEAVVAWEVAVAVLEKFDGDRFDTLKKHVEEHRNLTKEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y038_OSHVF
Sequence: MACSKMDVDKQCCICLDDEDVDRDNTIPCRHTVCRTCYVKPMLDQCPVCREPWEARKNDESAEEYTGRHYFHTYRNGGYRGVPRFESTWGLSIDEERWQNYVQHIRPLYQGFLDERIIFENPIPVNMEYPLWEDIPHTRYLWTILKSIIINAKKIVKDVTNVPPFSPEVLEQFDDFFHEEPSRDKCTFPLRSQ
What are the official names of this protein?
Putative RING finger protein ORF38.
Protein: SL7_ECHPL
Sequence: MGRFIFVSFGLLVVFLSLSGTGADQDCLPDWSSHERHCYKVINEYKTWEEAEQYCTEEANGGHLVSFHNRQEVAFVVKLGYTILKADVVWIGLRDFWRECQWEWSNGAKLNYKGWSDEPNCFIAYTVGNRWVRRKCSSTHPFVCKSPA
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec 7, C-type lectin 7, CTL-7.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: SCML1_PANTR
Sequence: MMSDSSSEIDVVKTRIPTYDEDDNTILYAYETKPEFVNKEPNIVSDASCNTEEQLRTVNDVLLHCQVIYDALQNLDKKTDVIRRKVSKIQRFYARSLWTNRKRSGYKKHSYRPVKKLKLQKMKKNEVYETFSYPQSYSPTLPVSRRENNSPSNLPRPPFCMEEYQRAEPEEDPILSRTPSPVHPSDFCEHNYQSYYASDGAMYGSSSGLCLGNPRADSIHNTYSTDHASAVSPSVTRSPVGNDGCIAEGNITKHPSTWSVEAVVLFLKQTDPVALCPLVDLFRSHEVDGKALLLLTSDVLLKHFGVKLGTAVKLCYYIDRLKQGKCFEN
What is the function of this protein?
Putative Polycomb group (PcG) protein.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  May be involved in spermatogenesis during sexual maturation (By similarity).
What are the official names of this protein?
Sex comb on midleg-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD_BRUA2
Sequence: MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANGFILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAPLSSYYAGTGELRIINGMAPVEEVTAEIERILVPA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_SHEB2
Sequence: MSLADSVLAINNDLPIRTDSPVHSGKVRSVYWLTDADSRRLITTKGYNVPEDTPLAIMVISDRISAFDCIFHGEGGLKGIPGKGAALNAISNHWFKLFAENGLADSHILDIPHPFVWIVQKARPIKVEAICRQYITGSMWRAYSKGERVFCGITLPEGLEKDQKLPELLITPSTKGILTGIPGVPAQDDVNISRSDIEANYQAFGFEKLADIDLYEKLLKDGFKVISKALADIDQVFVDTKFEFGYVTDKDGNSKLIYMDEVGTPDSSRIWDGAAYRDGKILENSKEGFRQFLLNHFPDPDVLLNKDRMPEREALARDNDLPLEAMMQVSRTYTGVAEKVTGAPIPLPANPKADIIKILKDEYDLIV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: UNI_ARATH
Sequence: MGSCFSLQVSDQTLNRIFNCLIGKSYIRTLEKNLRALQREMEDLRAIQHEVQNKVARDEARHQRRLEAVQVWLDRVNSVDIECKDLLSVTPVELQKLCLCGLCSKYVCSSYKYGKKVFLLLEEVKKLNSEGNFDEVSQPPPRSEVEERPTQPTIGQEDMLEKAWNRLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAEIGGTFDIVIWIVVSKGVMISKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPYPSEVNKCKVAFTTRSREVCGEMGDHKPMQVNCLEPEDAWELFKNKVGDNTLSSDPVIVELAREVAQKCRGLPLALNVIGETMSSKTMVQEWEHAIHVFNTSAAEFSDMQNKILPILKYSYDSLGDEHIKSCFLYCALFPEDGEIYNEKLIDYWICEGFIGEDQVIKRARNKGYAMLGTLTRANLLTKVGTYYCVMHDVVREMALWIASDFGKQKENFVVQAGVGLHEIPKVKDWGAVRKMSLMDNDIEEITCESKCSELTTLFLQSNKLKNLPGAFIRYMQKLVVLDLSYNRDFNKLPEQISGLVSLQFLDLSNTSIEHMPIGLKELKKLTFLDLTYTDRLCSISGISRLLSLRLLRLLGSKVHGDASVLKELQQLQNLQELAITVSAELISLDQRLAKLISNLCIEGFLQKPFDLSFLASMENLSSLRVENSYFSEIKCRESETESSYLRINPKIPCFTNLSRLEIMKCHSMKDLTWILFAPNLVVLLIEDSREVGEIINKEKATNLTSITPFLKLEWLILYNLPKLESIYWSPLPFPVLLTMDVSNCPKLRKLPLNATSVSKVEEFEIHMYPPPEQENELEWEDDDTKNRFLPSIKPYKYFVYPGMSFLTV
What is the function of this protein?
Involved in disease resistance via the salicylic acid (SA) signaling pathway (PubMed:18315541, PubMed:27016096).  Involved in shoot architecture development via the cytokinin signaling pathway (PubMed:18315541, PubMed:27016096).
What are the official names of this protein?
Disease resistance protein UNI, Protein UNI.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: FBW3_ARATH
Sequence: MEFECQERLEAANDQRSESGLLNTDLRIGNDGSVEIPNVKLCCQKKKGTLVPSGSKQLLSDKDLSTTIIDLPQALISEILNCLDPKELGLVSCVSTYLHRLASEHHAWKEFYRERWGLPVVFGAASSGLSDERSWKDLFVEREFRSRTFLGRYSIDTLYGHTEAVRTVFLLASAKLVFTSGYDSIVRMWDMEEGLSIAASKPLGCTIRALAADTKLLVAGGTDGFIHCWKSLDGLRNLFDLTGFQKEKTEFRLWGHEGPITSLALDMTSIFSGSWDMSVRIWDRSSMKCVKTLRHSDWVWGLAPHETTLASTSGSDVYIWDVSSETPLAIIPDAHEGTTYSLARSHTGDFLFTGGEDGGIKMFEIRRYGSETSVVLISQWMPHTSPVYSLSFEFPWLVSASGDGKLALIDVRKLLKTNRCAYSKRISSSTVEPPQRMLHGFGSNLFSVDVGYDRIVCGGEEGTVRIWNFTQALEIERRTRALKGMRHENRMRRRRMQMEMNAKNGRPDQCSIAAHKNPINGERNRAWHSKRRASGKAKA
What are the official names of this protein?
F-box/WD-40 repeat-containing protein At5g21040.
Protein: GLMM_DESVM
Sequence: MGKRLFGTDGLRGQVNIYPMTADVALRLGLAAGTHFRNGNRRHRVVIGKDTRLSGYVFESALTAGLCAAGMDVYLVGPLPTPAIAFLTRNMRADLGVVISASHNPFMDNGIKFFDKDGFKLPDEMENKITDMVLDPDWQWDYPAPERVGRAAKIEDSPGRYIVYLKNSFPAHLTLDGMRVVLDCANGANYKVAPLALEELGAEVIKIGTEPNGLNINHQCGSLYPGVAAGKVLETRADVGLALDGDADRLIVVDEKGTVLDGDQIMALCADDMLRRGALRNNTLVATVMSNMALEVYMKERGCKLLRTPVGDRYVVEAMRREGANLGGEQSGHLIFMDHGTTGDGLMAALQILRIMRERDRPLSELAGQLQLFPQELINVHVERKIPFEQCQPVLDGVAKVEAELGDRGRVLLRYSGTEAVCRVMVEGEDPEQVKRLASLLAETVQKHLR
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RPOC_CLAMS
Sequence: MLDVTTFDELRIGLATADDIRRWSHGEVKKPETINYRTLKPEKDGLFGEQIFGPSRDWECSCGKYKRVRFKGIVCERCGVEVTKSAVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDMAPKDLEKVIYFAAYMVISVDEDARHEDMPGLENELRLEIKTLQDQRDSQIAERLGRLETDLAALEAEGAKSDQKRRAKDGAEKEMGQTRKAFDEDISRLERVWEEFRSLKVGELKPEDAVFHELQDRFGIYFEAHMGAEAIQKRLEAFDLEAEGELLREQIATGKGQKKIRAIKRLRVVSSFLATGNSPAAMVLQVVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLRRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGTGNRALKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIIVGPQLKLHQCGLPKQMALELFKPFVIKRLIDLSHAQNIKAAKRMVERSRGQVWDVLEEIIRERPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCAAFNADFDGDQMAVHLPLSVEAQAEARILMLASNNILKPSDGRPVTLPTQDMIIGLHHLTTLKEGVAGEGRAFSSVAEAILAKDQLSLDLNAKVRIRLHDIYFGEGEAPEGVELDEKGKTVGPVLLETTLGRALFNETLPVDYPYIEAVADKGKLSEIVNDLAERYPKVEVAAALDRIKDAGFYWATRSGVTVALSDVLTPPTKAAILSGYEKQAAKVQGQFEKGLTTNAERRQELIEIWNKATAEVAKAMEDNLPADNNINRMVSSGARGNWMQVRQIAGMRGLVSNPKGEIIPRPIVHSYREGLTVAEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREDDCGTSRGLDLPIATKGADGSSVRDSNVENSVYARSLAADAVNEAGEVVAPAGSDVGDVMIDHLIAAGVHEIKVRSVLTCESAVGVCAACYGRSLATGKLVDIGEVVGIIAAQSIGEPGTQLTMRTFHTGGVASADDITQGLPRVQELFEARTPKGASPIAEAAGRITIEDTDRSRKVILTPDNGDEPHIYPVLKRATLLVEDGQHVELGQQLHVGAIDPKEVLRVKGVREVQKHLVGGVQGVYRSQGVPIHDKHIEVIVRQMLRKVTVVEHGDTDLLPGELVDRARYNEVNRATLTEGKKTASARQEVMGITKASLATESWLSAASFQETTRVLTQAAMEGKSDPLMGLKENVIIGKLIPAGTGLAKYRDVTVTATEEAKAERYPNRIFTDESVFNESDLSFVDFDSFSSDDYTPGTYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: 4ET_HUMAN
Sequence: MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSMPAKVISVDELEYRQ
What is the function of this protein?
EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837).  Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837).  Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837).  Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity).  Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484).  Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837).  Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837).  Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E transporter, 4E-T, eIF4E transporter, Eukaryotic translation initiation factor 4E nuclear import factor 1.
What is the protein family that this protein belongs to?
Belongs to the 4E-T/EIF4E-T family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic (PubMed:10856257). Mainly localizes to processing bodies (P-bodies) (PubMed:16157702). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:10856257). Localization to nuclear foci and speckles requires active transcription (PubMed:22090346).
Protein: AREL1_MOUSE
Sequence: MFYVIGGIIVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVDIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHSYSLAIHELGPQEEENNEVSFEKSVTSNRQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYLYNANNCTSTPWHLPPMHMSSSQRRPSTAIEEDDEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFARFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML
What is the function of this protein?
E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (By similarity).  E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).  Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (By similarity).  Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312).
What are the official names of this protein?
Apoptosis-resistant E3 ubiquitin protein ligase 1, Apoptosis-resistant HECT-type E3 ubiquitin transferase 1.
Protein: DEOD_BACC4
Sequence: MSVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPTANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFTGEETTSEERQTTFNEMIEIALDAAIQQ
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: SYGA_BAUCH
Sequence: MSNTFQDLIMLLQNYWAQQGCTIIQPIDIAVGAGTSHPMTCLLALGPEPIATAYVQPSRRPTDGRYGNNPNRLQHYYQFQVILKPSPHNIQEIYLDSLKQIGLDPTLNDIRFVEDNWENQTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECQIVAGEITYGLERIAMHLQNVENVFDLRWNKGAFGYITYGDIFLQNEVEQSTYNFEYADANLLLNCFDFYEKEAQKLLALDKPLPLPAYECVLKAVHNFNMLEARKAISVIERQCYILRLRTLTKAVAQAYYISRQSLGFPMCKRHKKRR
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTHD3_PONAB
Sequence: MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
What is the function of this protein?
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability.  M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.  Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3.  The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (By similarity).  Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs.  Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity).  Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation.  Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons.  Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation.  The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules.  May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity).
What are the official names of this protein?
YTH domain-containing family protein 3.
What is the protein family that this protein belongs to?
Belongs to the YTHDF family. YTHDF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, P-body. Cytoplasm, Stress granule.