PharMolix/UniProtQA huggingface dataset:
Protein: PKNB_MYCTO
Sequence: MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ
What is the function of this protein?
Protein kinase that regulates many aspects of mycobacterial physiology.  Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins.
What are the official names of this protein?
Serine/threonine-protein kinase PknB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Localizes to septum and cell poles.
Protein: LDOC1_GORGO
Sequence: MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERASLLRQVRPPSCPVPFPETFNGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDEMKQCFGWDDDEDDDDEEEDDY
What is the function of this protein?
May have an important role in the development and/or progression of some cancers.
What are the official names of this protein?
Protein LDOC1.
What is the protein family that this protein belongs to?
Belongs to the LDOC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS7_PROMA
Sequence: MNLQRQAEIHRVTNETEVSVRLGLDGSGRCKVSSGIAFLDHMLHQLSSHGLLDLELVAKGDTHIDDHHTNEDVGIALGQALSKALGNRKGIYRFGQFTAPLDEALVQVILDCSGRPHINYELEIPTQKIGTYDTELVREFFVALANNSGLTLHIRQLNGSNSHHIVEACFKAFAKSLRMAIEADPRRGGSIPSSKGVLEQAGDNNTEKSK
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECPB_ECODH
Sequence: MKKHLLPLALLFSGISPAQALDVGDISSFMNSDSSTLSKTIKNSTDSGRLINIRLERLSSPLDDGQVISMDKPDELLLTPASLLLPAQASEVIRFFYKGPADEKERYYRIVWFDQALSDAQRDNANRSAVATASARIGTILVVAPRQANYHFQYANGSLTNTGNATLRILAYGPCLKAANGKECKENYYLMPGKSRRFTRVDTADNKGRVALWQGDKFIPVK
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).
What are the official names of this protein?
Probable fimbrial chaperone EcpB.
What is the protein family that this protein belongs to?
Belongs to the EcpB/EcpE family.
Protein: DPOL_ASFL6
Sequence: MDRSEIVARENPVITQRVTNLLRTNAPLLFMPIDIHEVRYGAYMLFMYGSLENGYKAEVRIENIPVFFDVQIESDNTNQLFLKSLLAAENITYERLETLTQRPVMGYREKEKEFAPYIRIFFKSLYERRKAITYLNNMGYNTAADDTTCYYRMVSRELKLPLTTWIQLQHYSYEPRGLVHRFSVTPEDLVSYQDDGPTDHSIVMAYDIETYSPVKGTVPDPNQANDVVFMICMRIFWIHSTEPLASTCITMAPCKKSPEWTTIVCSSEKNLLLSFAEQFSRWAPDICTGFNDSRYDWPFIVEKSMQHGILEEVFNKMSLFWPQKLDTILKCYYVKEKRVKISAEKSIISSFLHTPGCLPIDVRNMCMQLYPKAEKTSLKAFLENCGLDSKVDLPYHLMWKYYETRDSEKMADVAYYCIIDAQRCQDLLVRHNVIPDRREVGILSYTSLYDCIYYAGGHKVCNMLIAYAIHDEYGRIACSTIARGKREHGKYPGAFVIDPVKGLEQDKPTTGLDFASLYPSLIMAYNFSPEKFVASRDEANSLMAKGESLHYVSFHFNNRLVEGWFVRHNNVPDKMGLYPKVLIDLLNKRTALKQELKKLGEKKECIHESHPGFKELQFRHAMVDAKQKALKIFMNTFYGEAGNNLSPFFLLPLAGGVTSSGQYNLKLVYNFVINKGYGIKYGDTDSLYITCPDSLYTEVTDAYLNSQKTTKHYEQLCHEKVLLSMKAMSTLCAEVNEYLRQDNGTSYLRMAYEEVLFPVCFTGKKKYYGIAHVNTPNFNTKELFIRGIDIIKQGQTKLTKTIGTRIMEESMKLRRPEDHRPPLIEIVKTVLKDAVVNMKQWNFEDFIQTDAWRPDKDNKAVQIFMSRMHARREQLKKHGAAATSQFAEPEPGERFSYVIVEKQVQFDIQGHRTDTTRKGDKMEYVSEAKAKNLPIDILFYINNYVLGLCARFINENEEFQPPGNVSNKDEYAQRRAKSYLQKFVQSIHPKDKSVIKQGIVHRQCYKYVHQEIKKKIGIFADLYKEFFNNTTNPIESFIQSTQFMIHYFDEEQKVNHSMKKMVEQHAALAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPAGNPASNALMRAIFTQLITEEKKIVQALYNKGDEIHDLLTYIINNINYKIATFQTKQMLTFELSSTHVELLLKLNKTWLILVGIRVAKKHLHALLGLHNNEPPSKTFIQQAIEEECGSIKPSCYDFIS
What is the function of this protein?
DNA-directed DNA polymerase involved in viral DNA replication.
What are the official names of this protein?
DNA polymerase beta.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: DXS1_KITGR
Sequence: MPLLSRITGPADLRRLHPEQLPPLAAEIRAFLIDNVTRTGGHLGPNLGVVELSIALHRVFDSPHDRILWDTGHQAYVHKLLTGRQDFSRVRAKDGLSGYPSRAESPHDLIENSHASTALGHADGIAKADQLLGVDRCTVAVIGDGALTGGMAWEALNNIAEAEDRPLVIVVNDNERSYAPTIGGLAHHLATLRTTKGYERFLAWGKDALQRTPVVGPPLFDALHGAKKGFKDAFAPQGMFEDLGLKYLGPIDGHDIAGVEQALRRARNFGGPVIVHCLTVKGRGYRPAEQDEADRFHAVNPIDPYTCLPISPSAGASWTSVFGKEMLALGAERPELVAVTAAMLHPVGLGPFAKAYPGRTFDVGIAEQHAVASAAGLATGGLHPVVAVYATFLNRAFDQVLMDVALHRLGVTFVLDRAGVTGNDGASHNGMWDLSVLQVVPGLRIAAPRDAARVREHVRQAVAVEDAPTVVRFPKGELGPEAPAIERIGGVDVLARTGPAPDVLLVAVGPMAAACLDAAALLAADGITATVVDPCWVKPVDPALVELAGAHRMVVTVEDNGRTGGVGAALAQAMRDADVDTPLRDLGIPQEFLAHASRGEILEEIGLTGTGVAAQTAAHARRLLPGTGTRPGAQEYRPRMPLTDWSEPA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxyxylulose-5-phosphate synthase 1, DXP synthase 1, DXPS 1.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: HTPG_RHOPA
Sequence: MTMTDTASETKPFQAEVAELLNLMVHSVYSETDIFLRELISNASDALDKLRYESIAKPELMEKGGEPKIRIIPKKAPDTLTIVDNGIGMDRQELIDNLGTIAKSGTKSFISKLAETKDSAGLIGQFGVGFYAAFMVADKITVTSRRAGSDDVWTWTSAGGAGFEIAPASEEAAARVERGTEIVLHLKPDASKYLEDWQIERIVTEYSDNIQFPILLMPEEGEPRQINSASALWQRSKSELSEDDYKQAYKQIAGAFDDPAMTLHYRAEGRQSYAVLLFAPSTKPFDLFEPERKGKIKLYVRRVFITSEAELLPPYLRFLRGVIDSEDLPLNLSREMLQKNPQLAQIRTAVTGKVISELESLADKKPEDFTKIWDAFGPVLKEGLYEDFERREKLLSLARFTTTAGEKRSLKQYVEAMKENQTEIYYLVGDSLERLKSNPKLESATARGIEVLLLTDPVDAFWTSGQLDFGGKPLKSLSQGDVNFDLIPKLEQDQDKDNKDEAKVDEATVIAVIKDALGERVSDVKASQRLTSSASCLVAGGMGPDRELEKLLARANKGAGSKPILEINLQHPLVAALGDTKTDKAEAADLAFLLLEQAQILDGELPEDPAAFASRLNRLVLRGVVAHG
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_HELPH
Sequence: MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFAARDL
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFSA_METBU
Sequence: MVRNDLVMEIPWDIEATLLSRPNRFLGIVEMDESTSSGPFQEKVHIHDPGRLEDLLYPGNRLLLRKATNPKRKTGWDVIAAKADDGWILINSIFHRRIAEWAIANKVCSCFENVLEVIPEQKFGDSRLDFLLKKSDTELWVEVKGCTLIYGNTATFPDAPTTRGKRHVGELKKALESGSEALILIIILRKDALCFKANASIDPDFAEVFKDAVNAGVQVCPLVFGYEGRELFYKGMVPLCTEEYNSI
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: YDAP_BACSU
Sequence: MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQLKFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAGQVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLSVSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAKRELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGTSFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFLNACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARHFKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVKYKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEELAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSLKKSLKRLF
What are the official names of this protein?
Putative thiamine pyrophosphate-containing protein YdaP.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: Y9210_DICDI
Sequence: MIEEHGGIVQSDGSIQPIDMSSFEKKSGSKKKEKKLTPKNINLLVQQSNQSVKQQKDAQKKQTSNGFNNNNSSNIHDGGMGGGSSSDNMDGSLDYSINNILKKEYEKINRNQVSSFSDVENFSEDDEDDDAEDDDSSDDQVNNKKNKPKKPSKLMKHDSVDGKNKMTPISSTSKKKVQHQLKEKNKKKGIKNDKKKSKPTKPTPKSVSSLPPPKIDSSTNNDNGSSDDDNSAKFKKYLFSIEPQKFEHTIEIPPFREINEFYDQDDGYSILSKNKYIGNWRDHNQYKSFDFDEEIDNQLDDNIINNDNDNDNDNDDDNDNDNDNDNDNDNDNDDDENGEDNGEDLNINNNNNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNFTSIQNDLDLQNNLNLSPIIITSSSSSSSSSPIGRNEIKTSLVSESGRSISSPILIPSPTLSSKSNNQENDDPTLVKSNNSFIKSIFSSGKIKRNSLQEYSIRNS
What are the official names of this protein?
Putative uncharacterized protein DDB_G0287265.
Protein: IRAP_ECO57
Sequence: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL1RA_RABIT
Sequence: MRPSRSTRRHLISLLLFLFHSETACRPSGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNAKLEERIDVVPLEPQLLFLGIQRGKLCLSCVKSGDKMKLHLEAVNITDLGKNKEQDKRFTFIRSNSGPTTTFESASCPGWFLCTALEADQPVSLTNTPDDSIVVTKFYFQEDQ
What is the function of this protein?
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A.  Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
What are the official names of this protein?
Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CA1P_WHEAT
Sequence: MLLFAPTPPPSPATAHRRPGGSAASCIRCSSVRELDRSPSRPPLPPLAEAKRVVLVRHGQSTWNADGRIQGSSDFSVLTPKGESQAETSRLMLLADSFDACFTSPLARSRRTAEIIWDTRDKDLIPDYDLREIDLYSFQGLLKHEGKEKYGALFQQWQKNPSDCSIDGHYPVRELWDRAQGCWERILTHEGKSVLVVAHNAVNQALVATSLGLGTEYFRTLLQSNCGASVLDFTPQPGGRPPSVCLNRLNQTPSSPISAESSAGRKSSKRIILVCQGATQSSSEGSLGGVGYAPLNMLGVIQAQKTAELLLDLKVNSIICSPQVAAVDTATAICEVQEAAGCLGADCVPRYVEMKNLLGLEIDDAFLTKQKSLEQIVQSGWMGGMEHQKLKTLWAQSEDAWQALVNELPEDDGAESDRVVVAIGHPAIHLGLLCRCLNLTMDYMPSFHLDDGSISVIDFPDGPKGGGIVRCTNYTAHLGRWSVPITKSTENNDEF
What is the function of this protein?
Phosphoglycerate mutase-like protein lacking PGM activity, but having 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase activity.  Can dephosphorylate the closely related compounds 2-carboxy-D-arabinitol 1,5-bisphosphate (CABP) and 2-carboxy-D-ribitol-1,5-bisphosphate(CRBP), and 2,3-diphosphoglycerate.  Prevents the accumulation of D-glycero-2,3-pentodiulose-1,5-bisphosphate (PDBP) a potent inhibitor of ribulose-1,5-bisphosphate carboxylase (RuBisCO).  PDBP is produced during the oxidation of ribulose-1,5-bisphosphate, the substrate of RuBisCO.
What are the official names of this protein?
2-carboxy-D-arabinitol-1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: ITB4_MOUSE
Sequence: MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSDEDGSVAGGVEGEGSGWIRGATPRPPGEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT
What is the function of this protein?
Integrin alpha-6/beta-4 is a receptor for laminin.  It plays a critical structural role in the hemidesmosome of epithelial cells.  Is required for the regulation of keratinocyte polarity and motility.  ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.  ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.  ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
What are the official names of this protein?
Integrin beta-4.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid- anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
Protein: Y363_METJA
Sequence: MVYDNIKREIIGMLKRMPNKQADWDNDLLPTLKAMFNPKSVSNAKSQLISEGVISQEIVDGKKIITLIKDPYELQAPNVFDEEMFLAYYTDKLKEYFKHKLSTEGPEWDIFDVKEFIMHFPESGDLNDKLIEHPYEVRKSITNVYIEAYEELFNETPNVEFIHIRNPIDCRISLSELSSAHKGKLVEFRAMILQATKLKLRYAKGFYYCPKCGATKTLDLGFWDKPKEVGKSLTCPADGCDCKGLIFDEDLSGKVDFQEIKVQTPLQESIYANKHSTTVFYEFNKPKKAVYSGYVKIVGVPIVKENKNGSVGELYIHAFYIEKDDEDIEEIAKNLNEKDLELINRIAKDKNVIQKLSDYAFREVTGYDMIKRAVLLQLVSSGTNIDMRTSIHILMISDPGVGKSTLMESLIQKFPFVKKVYAVTSSGPGLVGSVVREKAEFGDSWVLKAGVLTEADGGVVCIDEFSRNKEVYDYLLGVMEQQKIEINKAGVIDAVLPARVAILAACNPRFGRFNPDLTVWEQINLPKELLDRFDLIFVIKDKIDKKKDEDIADFSIDNYNSKVRERKGKSSGKKFVINGVELNDELLLKYVLYARQIEPEISDEARKIIKEYYVSVRKMSEAKGTFGISARQLGSIIRLAVAHAKLRLSEVVKAVDAEEAIRLVDTCLKQIAYDPESGSIDIDKIAGTPKSKRDKVEKVLNIIKEISNSRDDGLAPEEEIYERAERAGLSEKEVEDAINYLKRVGDIYSPKSGYWQLMS
What are the official names of this protein?
Uncharacterized MCM-type protein MJ0363.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
Protein: STX7A_DICDI
Sequence: MYNNNNNFGGGGYNQGGGYNSGGYNNNGGGYNNNNGGYNNNNNNNGGYNNNRPQQQQQQQQQYVNNNNNSFDNNGYGGDDDVTNNSDYQSTTRNIQQIQNAVQILTKLVQLLGTPKDSMDTREKIRNCVDSTTHLISSESGKVKNLTSLASRSRDSKNKLLYQKLVKEFNNCLQQFKDIAQVATKKEKTTPLPVAPDHQQPTTFGRNNNSNNNNQNNHFLNNQQPYYDDDNREDEHQSLMESSRRQQLAQIEAEREYQNSIIQERDEGIRKIEQSIVEINEIFVDLSGLVAEQGVMINTIEASLESTTINTKEGVNHLREASKNQKSSRNKMCWIVLILLIVCAVLGVILFFTLRK
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome.  Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion.  May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles.
What are the official names of this protein?
Syntaxin-7A.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Endosome membrane; Single-pass membrane protein.
Protein: RPOC1_EUGLO
Sequence: MRDYVKINIASPKQILKWTERLTPKGKYIGKLKNSKKTLDKKGKCIRGGLFCEQIFGPTKKNTCRCGYYKNYKKSKKEKKHIKLCRICNVEITDPIIRNYRMGYIELNIPIINILYLNINPCYLAIITNLKINYLKQLHSGKAYITIKDKNQKEKKLTGGEAINDILSKIDLEKTLIKLTNNIHQYKEKNITIKNFKNILNKIKLYNYLLQTKIKFSWLLFKYLPVLPPNVRPIINMKNNQQISNDLNTLYASIINVNNKIIKLKESLIPDNYFINEKILLQKKVDQLINNEKYKENKLGKIINNKKLKSITENIKGKEGIIRENMLGKTVNFSGRSVIVVEPTLNLNECGLPKEMAINLFYPFIIKELIKLKLIKRLYKIKKITKILDIILENIIKNHYILLNRAPTLHRLNIQAFQPKLTIGKSIKLHPLVCSAFNADFDGDQMGVHIPLSLKAQAEARNILISINNCNSLKNGDPNILPSQDIILGCYFSNIENCNLLYILNKIQIYTNMEKIKMEYKKENLSIHNFIWLNFKNKQQIDKLKIKRKNLIKKIIFLRTTVGRILFNDIIKNFL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid.
Protein: ISPD_XANCB
Sequence: MTGSVWAIVPAAGRGTRFGGAVPKQYLHAAGQPLMAYTLAALAAHPAVAGIVVAIAPDDADWPGWTAVHAKPLLTCVGGATRAASVLAGLLALPDGVRADDFVLVHDAARPNLALADLDRLLEIGRGDPVGAILAAPVRDTLKRAGDDGGIDGTEPRQRLWRALTPQLFRRHQLIRGLTEASAAGVDVTDEAMAIERLGLRPLLVEGAEDNFKVTTPADLARFEFELANRDRGGASREAERSAMPSAATSVFSGARSAASGSEEV
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PHNN_RUEST
Sequence: MSVPADTSPAKGPVIAVVGPSGVGKDSLMSGLAVADPRLRSMRRVITRAPEAGGEDYQPVSEAEFQALVEADVFALHWNAHGLRYGIPRDIEKLREGATGVLVNLSRAVLLQAQEVFDDFRVISVTARPEVLAARLAGRGREDAAEVERRLARASLALPEGLRQVHEVDNSGALSAAIVEAQAIIQAERA
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Ribose 1,5-bisphosphate phosphokinase PhnN, Ribose 1,5-bisphosphokinase.
What is the protein family that this protein belongs to?
Belongs to the ribose 1,5-bisphosphokinase family.
Protein: FMP46_ASHGO
Sequence: MSLLRTLQMQPRVITVFAEHANVGAASEILGALKTASGPKCKVQVSTMFPTLEQLIYMSEINRTAVAAQVPRLSELLQKPSFSEEFSSPLAQCTQDGVWRSQGGLWVDWEKRLLGADGQSVHELLGSSTMTID
What is the function of this protein?
Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.
What are the official names of this protein?
Putative redox protein FMP46, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FMP46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYFA_ACIAC
Sequence: MNELDSLVDAARRMFADAATPTDLENAKAQFLGKAGRVTELLKGLAQLPVEEKKSRGAAVNVAKQAIEQALNERRQALADAELQAQLQAEALDVTLPGRQRGQGGLHPVSLTLERIEGIFGSMGFDVADGPEIESDWFNFTALNTPEDHPARSMHDTFYVEGGTASAPLLLRTHTSPMQIRHAVQHVKKHRALLDAGQPMPEIRVIAPGRTYRVDSDATHSPMFHQCEGLWIGENVSFKDLKVVFTAFCRTFFESDDLVLRFRPSFFPFTEPSAEIDIQFQDGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGMGPDRLTMLRYGVNDLRLFFDGDIRFLSQFQ
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCFT_RAT
Sequence: MEGRVSPVGSSHRLLTAAVLFRGPVEPLVFLANFALVLQGPLTTQYIWHRISTELGYNGTRHRENCGNQSADPVLKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAVLIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQNS
What is the function of this protein?
Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:18174275, PubMed:31792273).  Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:18174275).  Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity).  Protonation of residues in the outward open state primes the protein for transport (By similarity).  Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity).  Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:18174275).  Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity).  Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity).  Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).  Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity).
What are the official names of this protein?
Proton-coupled folate transporter, rPCFT, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SLC46A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity).
Protein: MDTM_SALTY
Sequence: MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICFIATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSGAALMHFVHWKVLFGIIAVMGLLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLATLLLGNLLLPHVWLWSVLGTSLYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVMAVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQRVRQHEAAELAAEK
What are the official names of this protein?
Multidrug resistance protein MdtM.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.