PharMolix/UniProtQA huggingface dataset:
Protein: RBN_ECOHS
Sequence: MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSRSMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITMEAKANSRGHSSTRQAATLAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV
What is the function of this protein?
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
What are the official names of this protein?
Ribonuclease BN, RNase BN, Ribonuclease Z homolog, RNase Z homolog.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family. RNase BN subfamily.
Protein: ATPL_STAA3
Sequence: MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIGVVIAFMTFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CDC16_SCHPO
Sequence: MPSIDCKRLQKLAPKSPENQSKCISRLRYMVMLDQVESDEGGNSSTRPYVWAVLLNAPPRNADEYIRYVRQGPSPMAQKIQNDVSRTLVVESQFHSRVSQSSLSRLLNAYVWKRGALYVQGMNVLASPFLYACKSENQAFQFFDRLLQNECPLYVLPNIDGVHRGAKLLDKCLEVLDHRLYTYLLSKGLTAKIYALPSILTLSACTAPLSEALTIWDFLFAYGIHLNILCVIAQMFIFREQLIDHPSPMTLLRTFPPLNAKNIMKITILLISKLPPELYNLLARHAWDSEAGVLIDRLT
What is the function of this protein?
Has a dual role in the cell cycle.  In mitosis, it is involved in maintenance of cdc2 kinase activity.  It is subsequently required for regulation of septum formation.  Could be involved in maintenance of cdc2 kinase activity by preventing, directly or indirectly, the degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2.
What are the official names of this protein?
Cell division control protein 16.
What is the protein family that this protein belongs to?
Belongs to the BUB2 family.
Protein: LIVG_SHIFL
Sequence: MSQPLLSVNGLMMRFGGLLAVNNVNLELYPQEIVSLIGPNGAGKTTVFNCLTGFYKPTGGTILLRDQHLEGLPGQQIARMGVVRTFQHVRLFREMTVIENLLVAQHQQLKTGLFSGLLKTPSFRRAQSEALDRAATWLERIGLLEHANRQASNLAYGDQRRLEIARCMVTQPEILMLDEPAAGLNPKETKELDELIAELRNHHNTTILLIEHDMKLVMGISDRIYVVNQGTPLANGTPEQIRNNPDVIRAYLGEA
What is the function of this protein?
Component of the leucine-specific transport system.
What are the official names of this protein?
High-affinity branched-chain amino acid transport ATP-binding protein LivG, LIV-I protein G.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: SYS_ECOBW
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINA_STRP4
Sequence: MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: TIG_DESVV
Sequence: MEYKVEDVSPVKKKVNVTVPVEEVDAALGAAIAMYRTSVNLDGFRKGKVPASIVENRFRKEIYAEATQDLVNVHINEIVTSLEVSPLSRIDFDGGELERGKEFSYTISFEVMPQFDLPDYEGFAVEQEKAVVDEKEVDEVIARIRRNMAELVPVAETRPGADGDVVVLDFAAFENGEPIEGVSAENFQLSLGEKQSLEDFENLVKTIPAGQEAEGPITFPDDFLNPDFAGKTVTMKVKVHAVKERRLPEIDDALAQKAGGFESMEKMRETVVTSYMQSREQLHKATAQKSMLDKLLKMVDFALPESMVDMYVGNLIEDMRVKMERQGRGLESLGKTPEQLREQVLPEAQQIARSQIFLLAAGRKEAVEVSEQEVDGQLQQLAMRSGQDFDTLKDYYVRNGLIFNLRDRLIADKAMDAIYAKANVTMVDPAPAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SYR1_BACCZ
Sequence: MDYKTQFAESLSNIFTNELTQKQILDLIETPKQDEFGDAAFPCFSLAKQYKKSPAIIAKEVAEKLSDPFFTKVEAVGPYVNVFFNRDTVSDAVLKTILAEKEEYGQNHFGCEKTVVIDYSSPNIAKPFSMGHLRSTMIGNSLKHIAEKCGYEVVGINYIGDWGTQFGKLITAYKKWGNEAVVKEDPIRELFKLYVQFHEEIKDDEELEEEGRAWFKKLEEGDEEAVELWNWFRHESLKEFSRIYELLGVEFTNFQGEAFYNNLMEDFIGILEEHDLLEESEGALVVNLEEEGMPPCLIRKSDGATIYATRDLTAALYRQNTFGFDKALYVVGPEQSLHFNQFFTVLKKLGYTWVDGMEHVPFGFILKDGKKMSTRKGRVILLEEVLEEAIELAKQNIEEKNPNLKQKEEVAKQVGAGAVIFHDLKNERMHNIEFSLENMLKFEGETGPYVQYTHARACSILRKESVEFETCTFTLKDDYSWNIVKLLNKFPEVIEAACNKNEPSVISKYVLDVAQSFNKYYGNVRILDENAEKDSRLALVYAVTVVLKEGLRLLGVEAPEEM
What are the official names of this protein?
Arginine--tRNA ligase 1, Arginyl-tRNA synthetase 1, ArgRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_ACTPJ
Sequence: MLKIYNTLKREKEEFKPINPNQVGMYVCGVTVYDLCHFGHGRTFVSFDVIARYLRYLGYNLRYVRNITDVDDKIIKRALENNETCDQLVDRMIAEMHKDFDDLNILRPDVEPRATKHIPEIVAMVEKLIANGHAYVAADGDVMFDVESFKKYGALSRQNLEQLQAGARVEIKSVKKNPMDFVLWKMSKEGEPSWQSPWGNGRPGWHIECSAMNSKELGEHFDIHGGGSDLMFPHHENEIAQSCCAHGGDYVNYWLHTGMLTIDDEKMSKSLGNFFTIRTMLEKYESETLRYFFLTAHYRSLLNYSLNNLDLARSALERLYTSLRGCDLSVEVAGGEQYVEAFKAAMDDDFNTPGALAVLFEIAREVNKLKTEDMAKANGLAVRLKELAGVLGLLYQDPEAFLQGDADNDEVAEIEALIKQRNEAKAAKNWAVADEVRDKLKAMNIVLEDTPNGTTWRKA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_BACSU
Sequence: MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELPEVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIVVEPSDASEIEKLMTAEQYEEMTQED
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: NU1M_HSUTH
Sequence: MFMLNLLTMIVPVLLAVAFLTLVERKILGYMQLRKGPNVVGPHGLLQPIADAVKLFTKEPLRPLTSSITMFIMAPILALTLALTMWIPLPMPHPLLNMNLGVLFMLAMSSLAVYALLWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSTLLMSGSYSLSTLIITQEYIWLILPSWPLTMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYANIIMMNALTTTLFLGAWNNPTTPELYTTNFAMKTLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWYVTMPIMMAGIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: I1_FOWPN
Sequence: MEQFDQLVLNSISAKALKSYLTTKIAEAIDELAAKKNSPKKKAQTKKPENRIPLDLINKNFVSKFGLKGYKDGVLNSLICSLVENNYFENGKLKRGKHDELVLLDIEKEILARIDENSSLNIDVLDVKVLANRLRTNADRFEFKGHTYYLEQNKTEDIINQLIKNSAISMDMKNTIKDTFYMISDELLDVFKNRLFKCPQVKDNIISRARLYEYFIKATKPDDSKIYVILKDDNIAKILNIETIVIDHFIYTKHSLLVSSISNQIDKYSKKFNDQFYSSISEYIKDNEKINLSKVIEYLTISTVKIENTVE
What is the function of this protein?
Late DNA-binding protein which binds to the hairpin form of the viral telomeric sequence.  Required for the production of mature virions (MV) (By similarity).
What are the official names of this protein?
Telomere-binding protein I1 homolog, Protein FPV90.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae I1 family.
What are the subcellular locations of this protein?
Virion. Note=Present in the virus core.
Protein: FBX47_HUMAN
Sequence: MASRINTNFTLIPNQKLRRSNRQTSCYSKTLGSGFQPISTFGNFKALPLEIFQIILKYLSVKDISMLSMVSKTVSQHIINYISTSSGSKRLLLQDFHNLELPDRRQDSAILEHYRSLGLLFKRCTLLLPTKERLKYIHKILTEVSCFKFNGCAAPMQCLGLTCYGMFLQTLTAGWDELECHRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDEFSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLALVCEKELYCMDWTVKMMQKVCKVFSTPVERKNFLQNVANAFACVIMEMLQSIMSGDRDEDDRSFLNLFHLVHAQANFHKEVLYLTMNTPLST
What is the function of this protein?
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
What are the official names of this protein?
F-box only protein 47.
Protein: TMX2_CAEEL
Sequence: MLIPRLDEVRRALTAFHFFNTLLALAFPVIRSTSLCDYVFAVEGNEQCEIDSREREILMFLLIILAWKGRKATNWMHYVNNIFLFSKIAGMFLFIRADILPGIIYILACLIVTVLFPEPVYNGPEQVTYFQGEQLFEELTRNRNTIWVIQFFTTWSPECRHTSPVFAELSQKFTLPNMKFGKLDIGRWAKEGERFRVNAHPMSRQLPTICVFKDAKEIARRPLVNDSRRAVPFVFSEENCVLAFDLLNLYNEQKEKKGAKAKKED
What are the official names of this protein?
Thioredoxin-related transmembrane protein 2 homolog, Thioredoxin domain-containing protein 14 homolog.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HRB_MOOTA
Sequence: MDTKALHTLTYGLYIITAKKGDRFNGQVANTVFQITSDPPTIAVSINKQNLTHEFIQAGQGFVISVLAREVPLSLIGQFGFKSGREMDKFAGINYKLSEGGLPYLADHTLAYLEASLNQTVDAGTHSIFIGTVTDAAVLLQGEPMTYAYYHQVKRGTTPKTAPTFTVGREKDKTALASPKYQCTICNYVYDPVQGDPEHGIAPGTPFADLPEDWTCPICGAGKDAFEQI
What is the function of this protein?
Has nitric oxide reductase activity in combination with FprA; probably involved in nitrosative stress protection.  Acts as an NADH:FprA oxidoreductase.
What are the official names of this protein?
High molecular weight rubredoxin, Nitric oxide reductase NADH:FprA oxidoreductase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the flavodoxin reductase family.
Protein: ATP6_DROME
Sequence: MMTNLFSVFDPSAIFNFSLNWLSTFLGLLMIPSIYWLMPSRYNIMWNSILLTLHKEFKTLLGPSGHNGSTFIFISLFSLILFNNFMGLFPYIFTSTSHLTLTLSLALPLWLCFMLYGWINHTQHMFAHLVPQGTPAILMPFMVCIETISNIIRPGTLAVRLTANMIAGHLLLTLLGNTGPSMSYILVTFLLMAQIALLVLESAVAMIQSYVFAVLSTLYSSEVN
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KCJ11_HUMAN
Sequence: MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
What is the function of this protein?
This receptor is controlled by G proteins.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  Can be blocked by extracellular barium (By similarity).  Subunit of ATP-sensitive potassium channels (KATP).  Can form cardiac and smooth muscle-type KATP channels with ABCC9.  KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THIE_PSEPK
Sequence: MKLRGLYAITDSQLLAGRFLSHVEAALEGGVCLLQYRDKTDDAARRLREAEGLMKLCERYGTQLLINDDAELAARLGVGVHLGQTDGPLTPARALLGRQAIIGSTCHASLELAAQAASEGASYVAFGRFFNSVTKPGAPAANVGLLEQARAQVKLPIAVIGGITLDNAAPLVAHGADLLAVIHGLFGADSAQEVTRRARAFNALFAS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL35_FRASN
Sequence: MPKMKTHTGTGKRFRVTGTGKIMRRRANRAHLLEHKTSRRTRRLYDEVPLSSADNRRIKRLLAR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL23_BACSU
Sequence: MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVESIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: NDUS2_TRYBB
Sequence: MLFLVVFLHLYRFTFGPQHPAAHGVLCCLLYFCGEFIVYIDCIIGYLHRGTEKLCEYKSVEQCLPYFDRLDYVSVCCNEHLLSLCFEYMLRCCLSLRCAFMRLLIVEFTRSFNGLLCISCMVLDLGCLSPLLWSFEERDKLMTFFDLCCGCRMHLAFMVLLGILDDFVFGFVDFLLLLIISCLFVMDCYDLLFVGNRLFYLRLRGLSFFDLYDLVFNSLSGVLSRSLGMVWDCRLFSCYELYFMFCYDYCFCFIGDAFDRLFLRLFDMRMSLLICKQCFFVGFFVFGFVCLFDYLYCDITIETIIMLFYSLWCCCLPGISFACVEHPKGEYCLLLCFCVGLCSRLRLRCADFLHICLLDVCLRGFLLHDLVAVLGNIDVVFGSVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  Component of the iron-sulfur (IP) fragment of the enzyme.  Component of the iron-sulfur (IP) fragment of the enzyme.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 49 kDa subunit homolog, NADH dehydrogenase subunit 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ILVC_LACLA
Sequence: MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGHAREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMYEGGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAELRKAMPFTQSGDDDAFKIYQ
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: DNAJ2_MYCTO
Sequence: MARDYYGLLGVSKNASDADIKRAYRKLARELHPDVNPDEAAQAKFKEISVAYEVLSDPDKRRIVDLGGDPLESAAAGGNGFGGFGGLGDVFEAFFGGGFGGGAASRGPIGRVRPGSDSLLRMRLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSVPIPCDTCGGRGEVQTVQRSLLGQMLTSRPCPTCRGVGVVIPDPCQQCMGDGRIRARREISVKIPAGVGDGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDVFVREGDHLHCTVSVPMVDAALGVTVTVDAILDGLSEITIPPGTQPGSVITLRGRGMPHLRSNTRGDLHVHVEVVVPTRLDHQDIELLRELKGRRDREVAEVRSTHAAAGGLFSRLRETFTGR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 2.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIAT2_TAKRU
Sequence: MKSWVRQGRRLVLVGMLAWVLLFLALLSYFLDARVNEPLTSTGSVLYQHPDTRRLASIQASQLHNTNLGSRPELASTLTATYTRDEPRPSATPEFSLEASQSPDSAPLAIYGGPEGIHQDYLDPQSLAAWSSFGTENIGSQSDPVIQSRERTSQNHGSITRYRGGEEEEEEEEEEERQENEDEDVANGLRNTAARKPGGDSSELEKYYFSKSISVVQRLWRGHVSADMLSPRLQRAMKDYVSANKHQVSYRGRRRPSQSAKELLCEMKAQARLQMVDGTQQPFSSLGWASLVPSLPLEQLHKRPDQGSFKSCAVVTSAGAILRSGLGREIDAHDAVLRFNAAPTEGYERDVGNKTTIRIINSQILANPNHRFNTSSLYKDVVLVAWDPAPYTLDLHKWYASPDYNLFGPYMEHRRAHPDQPFYILHPRYVWRLWDVIQGNTQENIQPNPPSSGFIGILLMMTLCEQVHVYEYIPSMRQSDLCHYHERYYDAACTLGAYHPLLYEKSLIQRINTGPGSDLRRKGRVTLPGFSTVDCDI
What is the function of this protein?
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.
What are the official names of this protein?
Beta-galactoside alpha-2,6-sialyltransferase 2, Alpha 2,6-ST 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2, ST6Gal II, ST6GalII, Sialyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: ATPG_PAEAT
Sequence: MGAQIRVYRQKISSTTSMRKIFKAMELIATSRIGKARARVAASLPYANAITRAVSAVATQSEIDHPLTTEPEQIRRAAVLIITSDRGLAGSYSASVLKQAEGLTELLHAEGKEVKAYLVGRKAQAYFDFRNRSYARVWTGGTDAPEFETAQEVGAALLEDFSTDFEEGGVDEIHVVYTRFKSMVTQEPTVIRLLPLEVVEEEAASESELLPLYEFEPETEQVLDALLPRYIESRIFAAMLQAAASELAARQRAMKSAGDNATDLIKKYTRLRNTARQAEITQELSEIVAGADALAS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: H3_EUPCR
Sequence: MARTKQTARKNVGGKAPRKHIGQKSARKTASTTAGMKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQEFKGDLRFQSSAVLALQEAAEAYLVSLFEDTNLCAIHAKRVTIMPKDMQLARRIRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RSMH_GLOC7
Sequence: MSKVLQMSTVNSLAFIHIPVLTQELIKGLDICPGGHYLDATVGGGGHSRQILETYGDVQVTAIDRDEVAIAAATTNLADYNTDRLTFWTGNFADYDPGNLKFDGIIADLGVSSPQLDSPERGFSFRLDAPLDMRMDRRQSTTAADIINSYSEIELANLFYNYGEERLSRQIAKQIVKQRPFFSTTELAEVISRSVPPKYRYGRIHPATRVFQGLRIAVNQELDSLESFLAKSPSWLKTNGIIGIISFHSLEDRIVKHQLRASPLLKVLTKKPIIPQSDEQAKNPRSRSAKLRLAQRKEQ
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.