PharMolix/UniProtQA huggingface dataset:
Protein: EPMA_SALA4
Sequence: MSETATWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGINLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCQPAESLSYQQAFQRHLEIDPLSADKTQLREAAAKLDLSNIADTEEDRDTLLQLLFTMGVEPHIGKEKPTFIYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDQNLLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAFTVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'.  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: FMT_RHILW
Sequence: MSLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGLPVFTPVNFKDPEERERFAALKADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGAAPIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGPNMTAGELHDRLMQVGAKAMAEAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFELEIGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLRGTPLAAGMRLS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: DRS9_PHYBI
Sequence: MAFLKKSLFLVLFLGLVSLSVCEEEKRENEDEEEQEDDEQSEEKRALWKTIIKGAGKMIGSLAKNLLGSQAQPESEQ
What is the function of this protein?
Has antimicrobial activity.  Exhibits a bactericidal activity towards several species of mollicutes, firmicutes and gracilicutes.  This peptide is membranotropic and it efficiently depolarizes the plasma membrane.
What are the official names of this protein?
Dermaseptin-B9, DRS-B9, Dermaseptin-gene related 3, Dermaseptin DRG3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ELI1_PHYVE
Sequence: TACTTTQQTAAYVALVSILSDDNFSQCSTDSGYSMLTATALPTTEQYTKMCASTACQAMIANIITLNPPDCELTVPTSGLVLNVYEYANGFNATCASL
What is the function of this protein?
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families.  Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins.  Might interact with the lipidic molecules of the plasma membrane (By similarity).
What are the official names of this protein?
Elicitin Vex1.
What is the protein family that this protein belongs to?
Belongs to the elicitin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMC_YERPB
Sequence: MHCAQYTAGRCRSCQWLDKPYPQQLADKQHHLESLLAGHAVTQWLAPVFGRESTFRNKAKMVVSGSVERPLLGMLHRDGTPVDLCACPLYPPSFEPVFTVLKTFIARAGLTPYNVARKRGELKFLLLTESTYNGELMLRFVLRSETKLAQLIAALPWLQQQLPQLAVISANIQPVHMAILEGEREIPLTEQQALPERFNQVPLYIRPQSFFQTNPPVAASLYATARQWVQEHEVHSMWDLFCGVGGFGLHCAGPETQLTGIEISAEAIACARQSAEQLGLKNVSFAALDSTRFATAEAQIPELVLVNPPRRGIGRELCDYLSQMAPKFILYSSCNAETMAKDISLLAGYHIERVQLFDMFPHTSHYEVLTLLALRR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: KTAP2_DROME
Sequence: MSASVSSKSTVVSSIISGLLSIVLFGTLRFCSEWFNDSQLRVLLGGYLFSWVFILSLTCVSNAEMVVFGQDFQAKLLPEIIFCLSLTVAAAGLVHRVCATTSVLFSLVGLYFLNRISTKYYSVQVPSVDAPTTRKGGKKFK
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Protein KRTCAP2 homolog, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2, Oligosaccharyl transferase subunit KCP2.
What is the protein family that this protein belongs to?
Belongs to the KRTCAP2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MAO1_PROMH
Sequence: MELEHESKRPLYIPYAGPILLEFPLLNKGSAFSEEERSTFNLHGLLPEAVETIEEQVERAYRQYLDFKNDNDKHIYLRNIQDTNETLFYRLLESHLTEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNRANIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRITGDEYNEFVDEFIQAVKRRWPNVLLQFEDFAQKNAMPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASRAAGRQLKDQTVAFLGAGSAGCGIAEQIIAQMKSEGLSDEQARARIFMVDRFGLLTDKLPNLLDFQSKLIQKSETLADWQTETDAISLLEVVKNAKPTILIGVSGQAGLFTEEIIREMHKHCERPTVMPLSNPTSRVEARPEDIINWTDGQALVATGSPFAPVTYKEKVYPIAQCNNSYIFPGIGLGVIASGAKRVTDAMLMVASRALADCSPMAKEGDGPLLPLLADIQQVSRYIAKQVAKEAQVQGVATVTSDSALEEAIERNYWEPEYRIYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: CPS3_SCHPO
Sequence: MTKKNAFKNSEDMKKYHLSEFNSEATSLTRPSPKSLQHVPCKFFRQGTCTSGKNCIFSHDLELATEKTICKYFQKGNCKFGSKCALEHVLPDGRKVKTRAFAPSTTAMGSSSQNISAAPMANIISNNDKILPMTTMASATASEEKNRIKDEALVIKKEESNVAIPSEVTVAANAFSASTEDVYSIVGDSLSKKASVKDFSDVTGIETIPAYVEATNGSSTVRSPHAKRSLSSISVKSSTSPFSGSKFLSSSSYPHTPEAHLNSNHISPASFGSGIRTRNIFNPESMSLGLKPPILNRSYSASMAPGFSMNTFTATGNLGRPTKSPSVPTSVGSNKSRKFPGINGSTLTATPSSLENLYPLSSRRSVPNLISSLGTSPSTFSSQFLKSTDRTHSFTSKLQSFNPVGTSLLASSLGTSQEDSVNYDIPDEFANEEDFIPNSLQELLTPEELERKMSHGDEAVSSSSASRFMSKVSSNLNSGNPTPYNSYNGTPTSSRFVAFFDRHRQESEKATPPSLNKVSQEPLTATTPKNLGNLTAISETLENGQTLKSNMASSIEKSKTSTEVVASYDTTLDEETQFQMDEA
What is the function of this protein?
Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate.  Has a role in meiosis.
What are the official names of this protein?
Protein cps3, Meiotically up-regulated gene 188 protein.
Protein: PYRH_FRAT1
Sequence: MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRRATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAVEIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDSKYGTWVTLD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_LIMRD
Sequence: MGIRKYKATTNGRRNMNGYDFAEITKTTPEKSLLAPLKHTAGRNSYGHITVRHRGGGTKRQYRIIDFKRIKDDVPATVKAIEYDPNRTANIALLVYADGTKSYIIAPKGLKVGMTVQSGPDADIKVGNALPLKNIPVGTVIHNIELKPGKGGQLARSAGASAQLLGKEEKYVLVRLSSGEVRMVLATCRATIGTVGNDEHALIIKGKAGRTRYAGQRPHVRGSVMNPNDHPHGGGEGKQPVGLPSPLSPWGKKTVGKKTRSHKARSNKFIVRGRKRGPHTR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ILVA_SALTY
Sequence: MAESQPLSVAPEGAEYLRAVLRAPVYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLTEEQKAHGVITASAGNHAQGVAFSSARLGVKSLIVMPKATADIKVDAVRGFGGEVLLHGANFDEAKAKAIELAQQQGFTWVPPFDHPMVIAGQGTLALELLQQDSHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIAVEAEDSACLKAALEAGHPVDLPRVGLFAEGVAVKRIGDETFRLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIAQHNIRGERLAHVLSGANVNFHGLRYVSERCELGEQREALLAVTIPEEKGSFLKFCQLLGGRMVTEFNYRFADAKNACIFVGVRVSQGLEERKEIITQLCDGGYSVVDLSDDEMAKLHVRYMVGGRPSKPLQERLYSFEFPESPGALLKFLHTLGTHWNISLFHYRSHGTDYGRVLAAFELGDHEPDFETRLHELGYECHDESNNPAFRFFLAG
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-Threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: HSLO_SHESH
Sequence: MSKDNLHRYLFENADVRGELVQLEQSYQEILSAHTYPTQIQELLGELMAATSLLTATLKFSGDISVQLQGDGPISLAVINGNNLQQLRGVARWDGELSDGATLQQLFGKGHMVITLTPAKGERYQGVVALDKDSLAACLEEYFTQSEQLPTKISLFANGKQAAGMLLQVLPSEGDHNAEFEHLEQLTATVKAEELFELEAEEVLHRLYHQEEVRLFDPIEVTFSCTCSRERSASAIRTVSKAEIDTIIAEQGKIEMGCEYCNTTYDFDSIDVEAIFSNTQAPETKQ
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_THEMA
Sequence: MRIEVVNVSHIFHRGTPLEKKALENVSLVINEGECLLVAGNTGSGKSTLLQIVAGLIEPTSGDVLYDGERKKGYEIRRNIGIAFQYPEDQFFAERVFDEVAFAVKNFYPDRDPVPLVKKAMEFVGLDFDSFKDRVPFFLSGGEKRRVAIASVIVHEPDILILDEPLVGLDREGKTDLLRIVEKWKTLGKTVILISHDIETVINHVDRVVVLEKGKKVFDGTRMEFLEKYDPRFFTSKMLVMRRLVLKGEDPFSMSDDELLERVCNS
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable).  Expression of the complex plus RibU in E. coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IL8_CANLF
Sequence: MTSKLAVALLAAFVLSAALCEAAVLSRVSSELRCQCIKTHSTPFHPKYIKELRVIDSGPHCENSEIIVKLFNGNEVCLDPKEKWVQKVVQIFLKKAEKQDP
What is the function of this protein?
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection.  Also plays an important role in neutrophil activation.  Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells.  G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
What are the official names of this protein?
Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: O1617_CONVE
Sequence: MMKLTCVLIIAVLFLTACQLTTAETRDEYRAVRSSDEVRNSRSTRDCSGSGYGCKNTPCCDGLTCRGPHQGPICL
What are the official names of this protein?
Conotoxin VnMKLT2-012.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1286_CORDI
Sequence: MFAIISVTGADHTGIIAAVATKCADLGVNINNVSQTIMDGYFTMILHVSFDDSATDIATIQESMADVEKDQNLVIRIQSQAIFDAMNII
What are the official names of this protein?
UPF0237 protein DIP1286.
What is the protein family that this protein belongs to?
Belongs to the UPF0237 family.
Protein: RL22_METM5
Sequence: MAKLKYKVEADPKNTARAMGRTLRISRKHAIELCRELSGMKLDAAVAYLNRVIALETPVPFKVHNKDLPHRKGKIGTHSGRFPQKASLEILQVLDNAKKNAEQKGLNTEKLRIKHISSNRGFTIKRYMPRAFGRASPKNQETIHIQVILEEFY
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: IFT57_DROME
Sequence: MQQDDEQEKSQQLQNFQSDDLLEKLKLLNYEKHLLKEFKLKPLSRFYFVKATNPGEQFYMFTLICWWLCKKLGKDMERPQEYDDPNTVAANIIKLLGEIDVPVDFQPNKLIRGAGPICLSVLEVLSTQACKVAQVGYQKLHIAQEEEFLGDYLEDNAEIILEKLEDEQNAAALSDDSDMELEAHNFRQLNWLNRPQKKSNGDVNLDERNPELDARMSDHQEWHLELERVLPQLKVFVKADARDWRTHISQMETLKTNILENSDTAEAQLKKLHSEFTFDLEKIESREKHLNNELKPLIQQFKELSIELSTIQYAQNQLQEDMEKQTAELNEVMMEQELKKEEMERRGQAMSDGSSVQQIRKAIAKLKDDTAQLNLEVALLVHAHDQDIVVRQLQQNQTTDLANNP
What is the function of this protein?
Required for the formation of cilia.
What are the official names of this protein?
Intraflagellar transport protein 57 homolog.
What is the protein family that this protein belongs to?
Belongs to the IFT57 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body.
Protein: LCRS_YERPE
Sequence: MKKARFTETQILRVLKEVEGGRHVKDVCRENGGSEASYYNWKSKYGGMESSDIKRMKEREEENRRLKQMYASLSLDHEILKDVVAKKL
What are the official names of this protein?
Low calcium response locus protein S.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: MURC_ECO57
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDL24_ARATH
Sequence: MDKTSQLPDELLVKVLSFLPTKDAVRTSLLSMRWKSLWMWLPKLEYDFRHYSVSEGQGLARFITLSLLGHKAPAIESLSLKLRYGAIGSIKPEDIYLWVSLAVHDSNVRELSLKLCTFAERPTKLPKSLYKCKSIVILKLKDEILVDVPRKVCLPSLKTLFLGRVTYSDEDSLHRLLSNCPVLEDLVVERDRIDNLGKLSVVVKSLQRLTLKMSCPCHLDGIMMNTPSLKYLKVTDERQESDSDNESDSDSPRYFYDFEDMPKLEEADFVLTFQNIKKFFKFVTSIKRLSLCLGVYTEESLYHEGLVFNQLEQLKICSCDSDWSILLSRLLESSPNLRELEAYVIEDHPDRRVDLPNQWGNQLNCVPKCLLSSLETFKWSEMYGLLQNQMDVAKYILRNARCLKSATIFFPTTYAKETRDEMIEELSLSFQGPETCQVFFH
What are the official names of this protein?
Putative F-box/FBD/LRR-repeat protein At4g00315.
Protein: Y9216_DICDI
Sequence: MQQPQNITTSSISNNNNNNTSLTLQQQQEQLQQLQIKRKRNLMKQLQHVSH
What are the official names of this protein?
Putative uncharacterized protein DDB_G0277499.
Protein: PTN12_MOUSE
Sequence: MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGNEITTGTMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQHPADLNRSYDKSADPMGKSESAIEHIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDRTSKPQELSAGALKVDDVSQNSCADCSAAHSHRAAESSEESQSNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVPDSPDGKSPDNHSQTLKTVSSTPNSTAEEEAHDLTEHHNSSPLLKAPLSFTNPLHSDDSDSDGGSSDGAVTRNKTSISTASATVSPASSAESACTRRVLPMSIARQEVAGTPHSGAEKDADVSEESPPPLPERTPESFVLADMPVRPEWHELPNQEWSEQRESEGLTTSGNEKHDAGGIHTEASADSPPAFSDKKDQITKSPAEVTDIGFGNRCGKPKGPREPPSEWT
What is the function of this protein?
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019).  Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2.  Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity).
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 12, MPTP-PEST, Protein-tyrosine phosphatase P19, P19-PTP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome. Note=Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2.
Protein: ORYZ_ASPOR
Sequence: MQSIKRTLLLLGAILPAVLGAPVQETRRAAEKLPGKYIVTFKPGIDEAKIQEHTTWATNIHQRSLERRGATGGDLPVGIERNYKINKFAAYAGSFDDATIEEIRKNEDVAYVEEDQIYYLDGLTTQKSAPWGLGSISHKGQQSTDYIYDTSAGEGTYAYVVDSGVNVDHEEFEGRASKAYNAAGGQHVDSIGHGTHVSGTIAGKTYGIAKKASILSVKVFQGESSSTSVILDGFNWAANDIVSKKRTSKAAINMSLGGGYSKAFNDAVENAFEQGVLSVVAAGNENSDAGQTSPASAPDAITVAAIQKSNNRASFSNFGKVVDVFAPGQDILSAWIGSSSATNTISGTSMATPHIVGLSLYLAALENLDGPAAVTKRIKELATKDVVKDVKGSPNLLAYNGNA
What is the function of this protein?
Secreted alkaline protease that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Alkaline protease 1, ALP, Aspergillopeptidase B, Aspergillus proteinase B, Elastase, Elastinolytic serine proteinase, Oryzin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CIB4_MOUSE
Sequence: MGQCLRYQMQWEDLEEYQALTFLTRNEILCIHDTFLKLCPSGKHYKEATLTMDQVSSLPALRVNPFRDRICRVFSHDNVFSFEDVLGMASVFSEQACPSLKIEYAFRIYDFNENGFIDEEDLEEIVLRLLKSDDASEDLLMDVMHHVLSESDLDNDSMLSFSEFEHAMAKSPDFMNSFRIHFWGC
What are the official names of this protein?
Calcium and integrin-binding family member 4.
Protein: DNAJ_CUPNH
Sequence: MAKRDYYEVLGVGKNASDDEIKKAYRKLAMKYHPDRNPEGKDGKIAEEKFKEVKEAYEMLSDPEKKAAYDQYGHAGVDPNMAGGFGGAQGYGGFAEAFGDIFGDIFGQQAGGRRGGGGPQAYRGADLRYSMEISLEQAAHGHEAQIRVPHWDDCDHCHGNGAEPGSSVETCPTCHGAGQVRVSQGFFTMQQTCPKCHGSGKYIPKPCTKCHGQGKLKSQKTLEVKIPAGIDEGMRIRSSGNGEPGINGGPPGDLYVEVHIKAHPMFERDGDDLHCQMPISFATAALGGDLEVPTLSGKATFPVPEATQSGKTFRLRGKGIKGVRSGYPGDLYVHVNVETPVKLTEAQKEMLRQFDRSVHEGGSRHSPQEQSWLDKVKSFFS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALCR_RABIT
Sequence: MKFTLTWRCFALFLLLHQPTPVNPASSNDTHPTVEPEPFLYVIGRKKLMDAQYKCYDRMEQLPPYQGEGPYCNRTWDGWMCWDDTPAGVLGFQYCPDYFPDFDPTEKVTKYCDETGVWFKHPGNNQTWSNYTMCNAFTPEKLQNAYVLYYLAIVGHSLSIFTLVISLGIFKCFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKVLHFFHQYMMSCNYFWMLCEGIYLHTLIVVAVFAKQQHLRWYYLLGWGFPLVPTTIHAITRAIYFNDNCWMSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETLEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKILGKIYDYLMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWVQFKIQWNQRWGRRPAHRSVSRTAASAEEGGIPVYIYHQEPRNDPAHSLGEEGAEIIPLNIIEQESSA
What is the function of this protein?
This is a receptor for calcitonin.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.  Isoform 2 has altered ligand binding and abolished coupling to phospholipase C.
What are the official names of this protein?
Calcitonin receptor, CT-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOB_SULSY
Sequence: MAMTSSGIILTTVEEVLSWGRRNSLWPVSVGLACCAIEMMHTAASRFDTDRLGIIFRGSPRQSDVLIVAGTVVNKVAPMLRLIYEQMPDPKWVISMGGCASAGGPFPTYPTLQGVDRIIPVDVYIPGCPPTPQALLWGILELQKKIKAKKEGKELIEIPIKVPQESKPISK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.