PharMolix/UniProtQA huggingface dataset:
Protein: MIAB_LEPBA
Sequence: MNPTLTESQTLTPTIQLGKVYVETYGCQMNEYDSGIVKELFRKEHYETTNVVEESDIIFLNTCAVRENAHAKIYGRLQSLGYLKKKNPNLVIGVLGCMAQNLGEDLFHQELPLDLIVGPDNYRTLPELIQNIRNGEKDVQLTRLSRSETYDELEPKVVNGIQAFVTIMRGCNNFCTFCVVPYTRGRERSREPKSIIHEIKQLQEMGVKQVTLLGQNVNSYSYESYDFCALVESILKETTIERVRFTSPHPKDFPDHLISLMAKEDRFSSQIHMPLQAGSSKVLRDMKRSYTKEEYLDLVKKIQSVIPDIGITSDIIVGFPGETEEEFLETLEVVKKVKFDMSYMFKYSEREGTIAKRKFIDDVPEEVKSRRLIELVELQTKISLEKNTSKIGKIFSILIENTSKKSKQELCGRSHCGRMVVFPIPEGMSQDLSDWIGKTVNVLIEQATSATLKGKLIV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PABP1_MOUSE
Sequence: MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKELFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
What is the function of this protein?
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability.  Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2.  Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.  Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs.  Involved in translationally coupled mRNA turnover.  Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.  Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.  By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability.
What are the official names of this protein?
Polyadenylate-binding protein 1, PABP-1, Poly(A)-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Stress granule. Nucleus. Cell projection, lamellipodium. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles between the cytoplasm and the nucleus (By similarity). During stress and in the absence of DDX3X, localizes to the nucleus (By similarity). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (By similarity).
Protein: HFQ_BURA4
Sequence: MSNKGQLLQDPFLNALRKEHVPVSIYLVNGIKLQGNIESFDQYVVLLRNTVTQMVYKHAISTVVPARPVNFHPDAEATTS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: MIAA_SALA4
Sequence: MNDVSKASLPKAIFLMGPTASGKTALAIALRKVLPVELISVDSALIYRGMDIGTAKPNADELKAAPHRLLDIRDPSQAYSAADFRRDALAQMAEITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRSRIEQQAAELGWEALHQQLQKIDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIELRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYIEGEISYDEMVYRGVCATRQLAKRQMTWLRGWEGVRWLDSENPDRARKEVLQVVGAIAD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NADK_SHEON
Sequence: MTTKFHTIGLIGKPHHPGTNQTLKRLHHWLTMQGYEVLVEERVATELGPHIVAVDLLEIGERCDLAIVVGGDGNMLGAARVLARFEVGVIGVNRGNLGFLTDLPPDAFEEALAKVLDGEFDTEHRFLLEAEVYRHGQLKASNTAVNEAVLHPGKIAHMIEFEVYIDNQFMYSQRADGMIVSTPTGSTAYALSAGGAILTPNLQALILVPMFPHTLSCRPIVVDACSTIKMVVSPENGENLEVSCDGHVHLAVLPGDEIIVRRSSEQLRLIHPKGHNYFHVLRSKLGWGSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_BURP6
Sequence: MKIYAVGGAIRDALLGLPVRDRDYVVVGATPEQMAAQRFRPVGKDFPVFLHPDTHEEYALARTERKTAAGYHGFQFYYAPDVTLEQDLVRRDLTINAMAREVSPDGALVGPVVDPFGGQADLRAKLFRHVGDAFVEDPVRILRVARFAARFAEFAVAPDTAALMRAMVDAGEVDALVPERVWQELARGLMEAKPSRMFAVLRECGALARILPEIDALFGVPQRADYHPEVDTGVHVMMVIDHAAKQGYSLPVRFAALTHDLGKATTPADVLPRHIGHEGRSVDLLKPLCERLRVPNECRDLALVVAREHGNLHRVMEMGAAALVRLLERADALRKPARFAEALQASEADARGRLGLETKPYPQAERLRQALVAARAVDAGAIAQGLAGEPAKIRDAVHRARVRAVAQAVGVAD
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: YFHS_BACSU
Sequence: MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSKYRELTQEIEARGGMKRNEADYSHGTRVSYD
What are the official names of this protein?
Uncharacterized protein YfhS.
Protein: SAX3_CAEEL
Sequence: MFNRKTLLCTILLVLQAVIRSFCEDASNLAPVIIEHPIDVVVSRGSPATLNCGAKPSTAKITWYKDGQPVITNKEQVNSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEVKSNEGSLKLAMLREDFRVRPRTVQALGGEMAVLECSPPRGFPEPVVSWRKDDKELRIQDMPRYTLHSDGNLIIDPVDRSDSGTYQCVANNMVGERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVTGDPQPQITWKRKNEPMPVTRAYIAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQTKPADQSVPAGGTATFECTLVGQPSPAYFWSKEGQQDLLFPSYVSADGRTKVSPTGTLTIEEVRQVDEGAYVCAGMNSAGSSLSKAALKVTTKAVTGNTPAKPPPTIEHGHQNQTLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGSLHIADLKKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDTEVELHWNAPSTSGAGPITGYIIQYYSPDLGQTWFNIPDYVASTEYRIKGLKPSHSYMFVIRAENEKGIGTPSVSSALVTTSKPAAQVALSDKNKMDMAIAEKRLTSEQLIKLEEVKTINSTAVRLFWKKRKLEELIDGYYIKWRGPPRTNDNQYVNVTSPSTENYVVSNLMPFTNYEFFVIPYHSGVHSIHGAPSNSMDVLTAEAPPSLPPEDVRIRMLNLTTLRISWKAPKADGINGILKGFQIVIVGQAPNNNRNITTNERAASVTLFHLVTGMTYKIRVAARSNGGVGVSHGTSEVIMNQDTLEKHLAAQQENESFLYGLINKSHVPVIVIVAILIIFVVIIIAYCYWRNSRNSDGKDRSFIKINDGSVHMASNNLWDVAQNPNQNPMYNTAGRMTMNNRNGQALYSLTPNAQDFFNNCDDYSGTMHRPGSEHHYHYAQLTGGPGNAMSTFYGNQYHDDPSPYATTTLVLSNQQPAWLNDKMLRAPAMPTNPVPPEPPARYADHTAGRRSRSSRASDGRGTLNGGLHHRTSGSQRSDSPPHTDVSYVQLHSSDGTGSSKERTGERRTPPNKTLMDFIPPPPSNPPPPGGHVYDDIFQTATRRQLNRGSTPREDTYDSVSDGAFARVDVNARPTSRNRNLGGRPLKGKRDDDSQRSSLMMDDDGGSSEADGENSEGDVPRGGVRKAVPRMGISASTLAHSCYGTNGTAQRFRSIPRNNGIVTQEQT
What is the function of this protein?
Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance.
What are the official names of this protein?
Protein sax-3, Sensory axon guidance 3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ROBO/SAX3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLMU_BURPS
Sequence: MNIVILAAGTGKRMRSALPKVLHPLAGRPLLSHVIDTARALAPSRLVVVIGHGAEQVRAAVAAPDVQFAVQEQQLGTGHAVRQALPLLDPSQPTLVLYGDVPLTRTATLKRLADAATDARYGVLTVTLDDPTGYGRIVRDQAGCVTRIVEQKDASPDELRIDEINTGIVVAPTAQLSMWLGALGNDNAQGEYYLTDVVEQAIEAGFEIVTTQPDDGWETLGVNSKAQLAELERIHQRNLADALLAAGVTLADPARIDVRGTLACGRDVSIDVNCVFEGDVTLADGVTIGANCVIRHAAIAAGARVDAFSHLDGATVGANAVVGPYARLRPGAVLAADAHVGNFVEVKNATLGQGSKANHLTYLGDADIGARVNVGAGTITCNYDGANKFRTVIEDDVFVGSDTQFVAPVRVGRGVTVAAGTTVWKDVAADMLVLNDKTQTAKSGYVRPVKKKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH43B_BACO1
Sequence: MMKNSCRLLLILIGLWMANVSLAQKTFRNPIITGMNPDPSICRVGDDFYLVTSTFEYFPGLPVYHSKDLVHWKLIGHALSRPENNPLMGCNASTGGQYAPTLRYHDGTFYVIGTNYGGKGSQGVFYVTAKNPAGPWSDPVWVGNWYVDPSIEFIDGKMYFLSPDNQGSFLLGVMDPETGTFVEALRKVASGLGGSSPEGPHFYKIGDYYYIMSAEGGTGYEHREVIQRSKSPWGPYEPSPVNPVLSNMNCPDHPFQAIGHADLVQLKDGSWWAVCLGIRPVNGKYQHLGRETFLAPVTWDADGWPKVGKDGVVQETYLFPNLPSHVWMEQPVRDDFDQETLGLDWTFIRNPAHSFWSLTEKPGSLRLKGTAINFTTNDSPSFIGRRQAAFNLTASAKVNFIPKVENEEAGLVVRADDKNHYDLLITERNGQRVAMIRKTLKDKVVDTTCKELPATGEVILSITATETTYTFEIKAAHVSAILGTASTRDVSNEVVGGFTGVFIGMYASGNGQANTNPADFDWFDFRCLD
What is the function of this protein?
Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches, converting the 'S' units to 'X' units.
What are the official names of this protein?
Non-reducing end alpha-L-arabinofuranosidase BoGH43B, Glycosyl hydrolase family protein 43B, BoGH43B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
What are the subcellular locations of this protein?
Periplasm. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus.
Protein: TRPA_SULTO
Sequence: MRRMLVTYMTLGYPNLESFYQFIEKSVELGTDILEIGLPPKYAKYDGPVIRKSYKAVTSWLKDYITPLKEVRKKVNIPIIILTYLEDYLSNLDNFLTTLHEIGIDGVLFPDLLIDFIDEYEEYVSKIKGKGVKAVLFTGPSLPDNLIIKASRISDIFLYYGVRPTTGIIIPVSVDSLITRVRNLVQNKLVVGFGLNDFNDLRKALSAGADGVAIGTAFIEEIEKNGIQSALHLVKTIRGILDEYS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RUTB_ECOKI
Sequence: MMTTLTARPEAITFDPQQTALIVVDMQNAYATPGGYLDLAGFDVSTTRPVIANIQTAVTAARTAGMLIIWFQNGWDEQYVEAGGPGSPNYHKSNALKTMRNQPLLQGKLLAKGSWDYQLVDELVPQPGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGVVLEDATHQAGPEFAQKAALFNIETFFGWVSDVETFCDALSSTSFARIA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: Y2172_AQUAE
Sequence: MIRGFFLILLFLLLAFFSENYVRSLEKLKEEITVRSELKGVEIQLYGEKGLEWRIQGKTLTYADNQVVINEPVIRTQDYTITSEKLYMNKKTRKGRLEGNVEIRGPNLYLRTTNAYIDLVKNISWGYNELILRKDTNVIKGRGFKIFFKPFKVQINEVESIHTTS
What are the official names of this protein?
Uncharacterized protein aq_2172.
Protein: DBND1_HUMAN
Sequence: MEPPEGAGTGEIVKEAEVPQAALGVPAQGTGDNGHTPVEEEVGGIPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENLNTESPAGLHPLPRAGYLRSPSWTRTRAEQSHEKQPLGDPERQATVLDTFLTVERPQED
What are the official names of this protein?
Dysbindin domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the dysbindin family.
Protein: ING3_PONAB
Sequence: MDLRDRFTEMREMDLQVQNAMDQLEQRASEFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQPVNNHHAHSHTPVEKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMREGRRTSSLKASYEAFKNNDFQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSSSSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.  Component of a SWR1-like complex that specifically mediates the removal of histone H2A. Z/H2AZ1 from the nucleosome (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MATK_SOLLC
Sequence: MEEIHRYLQPDSSQQHNFLYPLIFQEYIYALAQDHGLNRNRSILLENSGYNNKFSFLIVKRLITRMDQQNHLIISTNDSNKNPFLGCNKSLYSQMISEGFACIVEIPFSIRLISSLSSFEGKKIFKSHNLRSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYCNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEAFAKDFQVTLWLFKDPVMHYVRYEGKSILASKGTFPWMNKWKFYLVNFWQCHFSMYFNTGRIHINQLSNHSRDFMGYLSSVRLNHSMVRSQMLENSFLINNPIKKFDTLVPIIPLIGSLAKAHFCTGLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEEVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANSQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SOX17_HUMAN
Sequence: MSSPDAGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLGLQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPLPTPDTSPLDGVDPDPAFFAAPMPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGAISSVVSDASSAVYYCNYPDV
What is the function of this protein?
Acts as transcription regulator that binds target promoter DNA and bends the DNA.  Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'.  Modulates transcriptional regulation via WNT3A.  Inhibits Wnt signaling.  Promotes degradation of activated CTNNB1.  Plays a key role in the regulation of embryonic development.  Required for normal development of the definitive gut endoderm.  Required for normal looping of the embryonic heart tube.  Plays an important role in embryonic and postnatal vascular development, including development of arteries.  Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18.  Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis.  Probable transcriptional activator in the premeiotic germ cells.
What are the official names of this protein?
Transcription factor SOX-17.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_BURMA
Sequence: MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: GSA1_STAAR
Sequence: MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDEVMTGFRVGYHCAQGHFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFDTALSRIVK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 1, GSA 1, Glutamate-1-semialdehyde aminotransferase 1, GSA-AT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_STAAM
Sequence: MAKKVDKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQDQAGLIIPVEISVYEDRSFTFITKTPPAPVLLKKAAGIEKGSGEPNKTKVATVTKDQVREIANSKMQDLNAADEEAAMRIIEGTARSMGIVVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RBSA_CLOPE
Sequence: MGERTPMLKMVGVSKSFPGVKALDNVSLMAYGGEVTALMGENGAGKSTLMKILSGVYKKDEGKIFIEGREVEVKGIKSAEEAGITIIHQELSVLNNLTISENIFLGNEKHSKFTGRINKKLLDERSKMFLEQIGCDIDPNRLVSTLNVGEKQMIEIAKALTKNARIIIMDEPTTALTDVETENLFKVIENLRKKGIAIIYISHRMEEIFKICHRVEVLRDGKYAGSAEIKDIDNDKLIAMMVGRTIEDQFPYRDVKKGDLALEVKNLSCKEGVKGASFTLRKGEILGIAGLMGSGRTELAKTIFGEYKRTSGEISLNGSPININCISDAINNGICYLSEDRKKEGCILGMSVGENMTLCNLKKYENKFKSLDKKEEAKDIEYYIKKINIKTPNKEQFIKNLSGGNQQKVILAKWLMLSPEVLIIDEPTRGIDVGAKKEIYELLNELKASGKAIIMISSDLPEVLGISDRIMVMSEGRISGELNRDEANQESIMKLAVGINN
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YCIC_SALTI
Sequence: MSITAKSVYRDAGNFFRNQFITILLVSLLCAFITVVLGHAFSPSDAQIAQLSEGEHLAGSAGLFELVQNMTPEQQQILLRASAASTFSGLIGNAILAGGIILMIQLVSAGHRVSALRAIGASAPALPKLFILIFLTTLLVQIGIMLIVVPGIIMAIVLALAPVMLVEEKMGVFAAMRSSMRLAWANMKLVAPAVIGWLLAKTLLLLFAPSFAVLTPNVGAVLANTLSNLISAVLLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCS2_RHORT
Sequence: MREPAFTVGIEEEYLLVDRQSRALAADPPEALMTRLAAAFGDTNHGAVTPEFLRAQIEVGTKVCDSLAEAGEALGALRRVLAEEAKGFGLAPIAASTHPFAEWADLKHTPKERYDLLAEDLQAVVRRLVICGMHVHVGIEDPDLRMDLMAQVSYFLPHLLALTTSSPFWRGEDSGLKSYRIAVFSALPRTGLPDSFSSFAEYQRHVEVLVSAGLIEDSTRIWWDIRPSHRFPTLEMRIADVCTRLDDALCVAALFRCLLRMLYRLRRANQRWRHYARLLIAENRWRAQRYGLDGGLVDFGRGEVVPFADLIEELLELIAPDAAVFGCQAEVLHARTILHRGTSAHNQLRVFAEARAGGMTRDEALVAVVDHLIAQTVAPLGADAGAPGP
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: YTJE_ECOLI
Sequence: MSRFIFYKIILSKQKDM
What are the official names of this protein?
Protein YtjE.
Protein: BTUD_SHIBS
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVGLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLILTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RIMP_NITWN
Sequence: MTDPSAQNPDHELLDEPRLVVEPGVAARVAAIAAPVLQGMGYRLVRIKVSGEAGCTVQIMAERPDGSIQIEDCEAISKALSPVLDVADPIDKAYRLEISSPGIDRPLVRRSDFERYAGHLAKIEMAVAHQGRKRFRGVLQGVEDNAVRLHRDDIRNNDDESEVMLVMEDIADARLVLTDELIAESMRRGKIAEREMKQSLGILPPPPPHAKTDPAKRGTPKPKLENGKKAPGKIPPKNTKEHRLAAERLRRGDIDPIEGE
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_NEIGO
Sequence: DHEIAAAAGVPIPTIFEMEGEQGFRSRETAILKKLIVLPHIVLSTGGGAVLKEENRALIRKSGTVVYLHAPPETLLERTRCDNSRPLLQVADPLAKLRELYAARDPVYRQTADFTVESANCRETVQTLLKRLSR
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.