PharMolix/UniProtQA huggingface dataset:
Protein: EIF3C_VANPO
Sequence: MSRFFAASYEYDSASSSSEEDLLSSSEEELLSSSSLSEEESDDSFFNDSESESDFDSDDSDAKPYGPDWFKKQEFRRGGGGGNKFLKGASYSDSDESDEASKKVVKSAKEKLLDEMQTSSGKIDAAELTNDWITILNEFDSVTRLLTRAQQQNFGTPNIFVKVVAQVEDAVAASQEEINNKAVAKAFNTAKQRVKKISREHQTLLAKYREDPESFEKETSVEVDATPELAQFAVGKKTTDLSSIATTSSETGFFPALSIVLDSRGKKNIDQQALAQSMDDLLQTTKTPYEKIIAYLTLIPIRLDSSTNLSYQPIDQWKATYNDVSSLLSILDENINTYQVSELAPFNDSLENEPEANEKGVKTILGSILSFVDRLDDEFTKSLLNTDPHSSDYLIRLRDEQAIYNLILRTQLYLEATLPEDRQIDLLSRIFVRRLNHIYYKSNELIRIMEVAAWKVAPSSYTSKLTPYDGAVSDSYLSGVISTLTDALSKQQNQSLRKRAVLYNVYYTALNKEFQVAKDMLIESKVQSFINKSDPSLQILFNRVVVQLGLSAFKLCLIEECHQILNDLLASSHLREILGQQTLQRVTAHSNSSNADEREKLCLPFHEHINLDLIDVVFMTCSLLIEIPQMTAFYSGIKIKKIPYSQKSIRRALEHYEKSSFQGPPETLRDYILHSAKEMQKGNWKKSFELLKSIQAWALLPNSASVLDNLAERLQVESLKTYFFTNKRFYSKLSMKKLSDLFNLPEDKIVESLQAVITEYEIDASFNEDKSVLSIAKGAEITKLEEVASKLNKEVKITKERLHPSRGRR
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHR_COLGU
Sequence: MPVQGSQRRLLGSLNSTPTATPKLGLAANQTGAWCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYCFICCLALSDLLVSGSNMLETAVILLLEAGALAARAAVVQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAQRVVAAIWVASVLFSTLFIAYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIAQLHKRQRPAHQGFGLKGAATLTILLGIFFLCWGPFFLHLTLIVLCPQHPTCSCIFKNFNLFLALIICNAIIDPLIYAFRSQELRRTLKEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLNE_VIBVY
Sequence: MSLPSPLLPVAELAMQNAQQSGYLEHWPQALITQFQFISGLSKFVVETVQRDAQLAEGLPEMLAQESRQEAYRTRLAEQLQACHDEVAGHRVLRQFRNREMVYIAWKDFTQAWSLEASLSHLSELAEAMIFETYQWQYQLCCQEWGTPTNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRLIKALDQQTFDGFCYRVDMRLRPFGESGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGREMYPEYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNIKLGAGGIREIEFIAQVFQLIRGGREPALRQRGLLVTLEAIKQLQLLEEAQVCHLVEAYKYLRRLENLLQAMADKQTQTLPDNELEQLALAVAMGYSQWQALQNDVQQHMAKVHAVFVTLIGDEEDEVSPVERHFNELWDMAHNPEVIEQILQNDLACQNAATMSEQIIQFKADLAKKTLGPRGREVLNRLMPKLFSAIFADADAQFGLPRVLHLLHNIATRTTYLELLDEHPAALTQLVRLCTASPMISEQLARYPILLDELIDPQQLYNPIALDAYRTELRDFLARIPEDDVEQQMDALRQFKQICSLRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVHQAWQQVAEKYGEPTHLKDREGKGFAVVGYGKVGGWELGYNSDLDVVFLHDCPVNVYTDGKKEIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVCPVDAFEEYQHNDAWTWEHQALVRARMIYGDEHLASEFHRVRHQVLAKPREQAKLQKEVADMRAKMRDHLGGKKSDRFMLKQDQGGITDIEFLAQYLVLNYSAEKPKLTRWCDNVRIFETLIAQGVMEEAQAMLLTQAYTTMRDEIHRRNLLNLDADVALDKFVALRQGVSKAWQEWLESSTI
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: NACB_CANAL
Sequence: MPVDPEKLAKLQKSSAKKVGGSRVKAKKNIKTEQDDTKLIEALGKLKATKIEGVEEANFFREDGKVLHFNRVGVQGAPASNTFAFTGYPQEKNITQLIPQILPQLGAENLEILRQLAEQIQAGKTPKDFNTGSANAAADAGGEDIPDLVDQKFDDVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: ASPG1_DROME
Sequence: MRRHLRASLWILCLATMAFSILAAVNTSPKPTLTSAFSGKAGTTAVKANKTTGELLPMVINTWNFTAANVLAWRILKQSKGGLRQTRNAVVEGCSKCEKLQCDRTVGYGGSPDELGETTLDAMVMDGATMDVGAVAGLRRIKDAIKVARHVLEHTQHTMLVGDAASAFANAMGFESESLVTPESKDMWLQWTAENCQPNFWKNVHPDPKVSCGPYKPRPTPLTRWKEDRARNEYEIGRKNHDTIGMIAIDVESNIHAGTSTNGARHKIPGRVGDSPIPGAGAYADNEVGAAVATGDGDVMMRFLPSLLAVETMRAGKPPAEAAQEGLRRILKHHKDFMGALIAVDRLGNYGAACYGLAEFPFMVSSPAGADGPTRLETVKCIGGQDKVNIVAL
What is the function of this protein?
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
What are the official names of this protein?
Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase CG1827, Aspartylglucosaminidase, AGA, Glycosylasparaginase, N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase.
What is the protein family that this protein belongs to?
Belongs to the Ntn-hydrolase family.
Protein: DNAJ_RALSO
Sequence: MAKRDYYEVLGVGKNASDDEIKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEMLSDADKKAAYDQYGHAGVDPNMAGGFGAGAQGFGGFAEAFGDIFGDIFGQAQQGGRRGAGPQMYRGADLRYSMEITLEQAAHGYDTQIRVPHWDECDHCHGKGAEPGSSVETCPTCHGAGQVRVSQGFFTMQQTCPKCHGNGKYIPKPCSKCHGQGKVKSQKTLEVKIPAGIDEGMRIRSSGNGEPGINGGPPGDLYVEIHIKAHSVFERDGDDLHCQMPISFAVAAMGGDIEVPTLGGRVTFNVPEGTQAGKTFRLRGKGIKGVRSGYAGDLYVHVVIETPVRLTEHQRELLRQFDKSVHEGGSRHSPQEQSWLDKVKNFFSS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNPA_BORPP
Sequence: MLDRKLMESLGGWQGYGVERVEWPEDPGRTLSIYLKPTAKVMLCEQCGARCRQVHETTVRRVRDLPIFEYRVVLHVPRRRLWCEQCGGPRLERLAWLGRYQRVTDRLAQACSQLLQSSNVQAVARFFELGWHTVKTLDKARLRASVREPDWSKIEYLAMDEFALHKGHRYATVVVDPIGRQVLWIGPGRSRETARAFFEQLPPGAAQRIKAVAIDMTTAYELEIQAHSPQAEIVYDLFHVVAKYGREVIDRVRVDQANQLRQDRPARRIIKSSRWLLLRNRDNLDRQQAVRLDELLQANQPLLTVYVLRDELKRLWFYQRPAWARQAWNHWYEQAEQSGIAALNTFAQRLKGYLHGILARCRHPLNTSIVEGINNTIKVIKRRAYGYRDQEYFFLKIRAAFPGNAR
What is the function of this protein?
Involved in the transposition of the insertion sequence.
What are the official names of this protein?
Transposase for insertion sequence element IS1001.
What is the protein family that this protein belongs to?
Belongs to the transposase 12 family.
Protein: GPH_PSEPU
Sequence: GTLIDSVPDLAAAVDRMLLELGRPPADLEAVRHWVGNGAQVLVRRALAGGIEHDAVDDVLAEQGLALFMEAYAQSHELTVVYPGVKDTLRWLQKQGVEMALITNKPERFVAPLLDQMKIGRYFRWMIGGDTLPQKKPDPAALLFVMQMAGVTPQQSLFVGDSRSDVLAAKAAGVQCVGLTYGYNHGRPIHDETPSLVIDDLRALLPGCEDPATGITLADLQASQDRESTVAVTGKFWMKVIKALARWRWRA
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity).
What are the official names of this protein?
Probable phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: MUTH_YERPE
Sequence: MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEELMDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS2_CALJA
Sequence: MVPKLFTSQICLLPLLGLLSAEGSPHARPQQYSRAQWFSIQHIQTAPLHCTSAMRAINKYQSRCKNKNTFLHTTFADVVNVCGNTNMTCPHNASLNNCHHSGVQVPLTYCNLTGPQTISNCVYSSTQANKFYVVACENRDPRDPPQYPVVPVHLDTII
What is the function of this protein?
This is a non-secretory ribonuclease.  It is a pyrimidine specific nuclease with a slight preference for U.  Cytotoxin and helminthotoxin.  Possesses a wide variety of biological activities (By similarity).
What are the official names of this protein?
Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Protein: RLMB_VIBCH
Sequence: MSNELIYGIHAVNAVLQRDPARFVEAYVLKGRQDDRLLPVLNELMRLGVSIQEMSRKALDDKAEGANHQGLIARVKPARQLNENDLDDILAQHEQPLLLVLDGVTDPHNLGACLRNADAAGVAAVIVPKDKSAPLTATVSKVACGAAETVPLVRVTNLARTMRALQEKGVWFVGTAGEATHDIYQSKLTGSLAIVMGAEGDGMRRLTRETCDDLIKIPMAGSVSSLNVSVACGVCLFEAVRQRMANR
What is the function of this protein?
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
What are the official names of this protein?
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB, 23S rRNA (guanosine2251 2'-O)-methyltransferase, 23S rRNA Gm2251 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIA_MYCTO
Sequence: MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLERRSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARVEREITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAEAAAQTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAALRGSARLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGGYARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSYRWRRGSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWCGRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALVVATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTVVAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLPDPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSARQTRQTRSLVRVQIDPLHIG
What is the function of this protein?
Involved in the restart of stalled replication forks.  Recognizes and binds the arrested nascent DNA chain at stalled replication forks.  It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
What are the official names of this protein?
Probable primosomal protein N', ATP-dependent helicase PriA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PriA subfamily.
Protein: GNS_SALTI
Sequence: MNSEELTHKAEEEIAALISKKVAELRKKTGQEVSEIEFAPRETMKGLEGYHVKIKLL
What are the official names of this protein?
Protein gns.
What is the protein family that this protein belongs to?
Belongs to the gns family.
Protein: GNA11_MELGA
Sequence: MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDKKGFTKLVYQNIFTAMQSMIRAMETLKILYKYEQNKANAVLIREVDVEKVMTFEQPYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLSDVDRIATPGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  Acts as an activator of phospholipase C.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit alpha-11, G alpha-11, G-protein subunit alpha-11.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm.
Protein: NAC_METM7
Sequence: MFPGGGKFNPRMMKQMQKMMKDFGMDAEDLKAVKVTIELEDQLLVFEKPKVQVMDMLGNKTYSITGKAKKVAKEEEKIEDVEVKVEVTEEDIEMVSSQCGVSKEEAKKALEEANGDLAEAILKLGN
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: MSRQ_SALNS
Sequence: MRLTVKQITWLKVCLHLAGFLPLLWLFWAINHGGLSADPVKDIQHFTGRTALKFLLATLLVSPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLVLLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPIHYLWSVKILSPQPVIYAALALALLALRYRKFRQWWR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WIPI3_HUMAN
Sequence: MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMTDDKL
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066).  Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857).  In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 3, WIPI-3, WD repeat-containing protein 45-like, WDR45-like protein, WD repeat-containing protein 45B, WIPI49-like protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure. Lysosome.
Protein: MNMA_PSET1
Sequence: MSENSHIKVIVGMSGGVDSSVSAYLLKQQGYQVEGLFMKNWEEDDNDEYCAAADDLKDAQAVCDKLGIELHTVNFAAEYWDNVFEYFLAEYKAGRTPNPDIMCNKEIKFKAFLEFAAQALGADFIATGHYVRRELRDDKYVMCRGLDDNKDQSYFLYTLSHEHIGQTLFPVGDIAKPEVRRIAEEQDLITHDKKDSTGICFIGERKFKDFLQKFLPAQPGVIEDTDGNNVGEHEGLMYHTLGQRKGLLIGGMKEGSGEPWYVVDKDLERNVLIVGQGKDHPRLYSNGLNANQLHWVDRIGPKGTTRCTVKTRYRQEDLSCTLLVGEDGMARVLFDEPQKAVTPGQSAVFYAEDVCLGGGIIDSVIK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NYLB_FLASK
Sequence: MNARSTGQHPARYPGAAAGEPTLDSWQEAPHNRWAFARLGELLPTAAVSRRDPATPAEPVVRLDALATRLPDLEQRLEETCTDAFLVLRGSEVLAEYYRAGFAPDDRHLLMSVSKSLCGTVVGALIDEGRIDPAQPVTEYVPELAGSVYDGPSVLQVLDMQISIDYNEDYVDPASEVQTHDRSAGWRTRRDGDPADTYEFLTTLRGDGGTGEFQYCSANTDVLAWIVERVTGLRYVEALSTYLWAKLDADRDATITVDQTGFGFANGGVSCTARDLARVGRMMLDGGVAPGGRVVSQGWVESVLAGGSREAMTDEGFTSAFPEGSYTRQWWCTGNERGNVSGIGIHGQNLWLDPRTDSVIVKLSSWPDPDTRHWHGLQSGILLDVSRALDAV
What is the function of this protein?
Involved in nylon oligomer degradation.
What are the official names of this protein?
6-aminohexanoate-dimer hydrolase, 6-aminohexanoic acid linear oligomer hydrolase, Nylon oligomers-degrading enzyme EII.
Protein: RLMH_DESDA
Sequence: MAGKPLRCISVGKLKTPFWKDAAAHYLTRIKRWRHLEYTEVRDGDAALPPDQRNALEGRRIVEALAPQDVALVLDEHGQKLSSPQLAALLRRLDQEARGRACFVVGGAWGLDDSVRQRAFKVLSLSDMTLPHELARVVLLEQIYRAECILRKVPYHH
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_AKKM8
Sequence: MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGMNSRKIVLPSDASQEELLRIVRELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGFHPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANAVVIGRSMIVGKPMAHLLMSKQANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASAKRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GCSPB_LEGPL
Sequence: MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFSIDTNFYPLGSCTMKYNPRGVHKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITGMPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIPDAAHGTNPASAVMCGFKVVEIATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGANLNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDSGYHWATRQDYPQSIGRLSCFMGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKELTKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRLLDYGVHAPTTYFPLLVPECLLIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYFATHE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: NCAP_I81A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGGMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLVVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSKYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPVVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.