PharMolix/UniProtQA huggingface dataset:
Protein: CH602_THEFY
Sequence: MPKILEFDESARRALERGVNRLADAVKVTLGPKGRNVVIDKKWGAPTITNDGVTVAREVELEDPYENLGAQLVKEVATKTNDAAGDGTTTATVLAQALVNEGLRSVAAGASPILLKRGIDAAAQAVSETLLSRAREIDERGDIAYVATNSAQDKQIGELIAEAFDKVGKDGVITVEESQTFGMDLEFTEGLQFDKGYISPYFVTDPDRQEAVLEDALILIHQGKISNLAELLPLLEKIVQTKKPLLIIAEDVEGDALGALVLNKMRGTLSVAAVKAPGFGERRKAMLQDIAILTGGQVIAEEVGLTLENAELDVLGKARRITVTKDTTTIVDGAGDQSEVNDRINQIRKEIEATDSDWDREKLQERLAKLAGGVCVLRVGAATEVELKERKHRLEDAISATRAAVEEGIIAGGGSALVHAAKTLEGDLGRTGDEATGVAIVRRALVAPARWIANNAGAEGNVVVSRIAELEPGHGYNAATGEYGDLVAQGIIDPVKVTRSAVQNAASIAGMLLTTEALVVEKPEEEENAEGGHGHSH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_BARQU
Sequence: MAKVIGIDLGTTNSCVAVMDGKNAKVIENSEGARTTPSVVAFTDGGERLVGQPAKRQAVTNPEGTIFAVKRLIGRRFDDPMVEKDKALVPYKIVKGDNGDAWVEEAGKKYSPSQISAMILQKMKETAESYLGEKVEQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKDGKTIAVYDLGGGTFDISVLEIGDGVFEVKSTNGDTFLGGEDFDMRLVGYFADEFKKEQGIDLKNDKLALQRLKEAAEKAKIELSSSQQTEINLPFITADQSGPKHLTMKLTRAKFESLVDDLVQRTIEPCKAALKDAGLKAGEIDEVVLVGGMTRMPKIQEVVQSFFGKDPHKGVNPDEVVAMGAAIQGGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTKKSQVFSTADDNQNAVTIRVFQGEREMANDNKLLAQFDLVGIPPAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEHQIRIQASGGLSDADIEKMVKDAEEHAAEDKKRREGVEARNQAEALIHSTEKSLTEYGDKISTEEKEQIETAISDLKSALDGTDPEEVTAKMQKLAEVSMKLGQAMYEASQAATANTETDTKSDDVVDADFEEISDKKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: SYL_MYCSK
Sequence: MTETPTAQPDRAADADTPQHRYTAELAGQIEGAWQQTWAVEGTFNVPNPVGELAPPDGTVPADKMFVQDMFPYPSGEGLHVGHPLGYIATDVYARYYRMTGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHDTRRSFSTTDVDFYTWTQWIFLQIYNAWFDRDANRARPIAELIGEFESGVRTLDDGRPWSELSAGERADVVDSYRLVYRADSMVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYSDRLLEDLEVLDWPDKVKTMQRNWIGRSTGASVQFGTDAGDIEVFTTRPDTLFGATYLVLAPEHPLVEQLAAEQWPDDVDGRWTFGATTPREAVAAYRASIAAKSDLERQENKTKTGAFLGAYATNPANGQQVPIFIADYVLIGYGTGAIMAVPGHDQRDWEFAHEFGLPVVEVISGGDISEAAYAGDGLLVNSDYLDGLDVAAAKAAITDRLVADGRGRARVEYKLRDWLFARQRYWGEPFPIVYDSDGRPHPLPESALPVELPDVPDYSPVLFDPDDADSEPNPPLNKATDWVHVELDLGDGLQTYTRDTNVMPQWAGSSWYELRYTDPLNKEALCAKENEAYWMGPQPAEHGPDDPGGVDLYVGGVEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAFAYTDSRGSYVPAAEVVERDGKFWFEGAEVFQEFGKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRLVVDEQSGAVRVANHEALDTDTLRALHRTVAGVSEDYAALRNNTAAAKLIEYTNHLTKEGVTARAAIEPLVLMVAPLAPHLAEELWRRLGHDTSLAHGPFPVADPQYLVTDTVEYPVQVNGKVRSRITVDADAGKDTLEAAALADEKVQAFLNGATPKKVIVVPGRLVNLVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_BURL3
Sequence: MARIAGVNIPNHQHTEIGLTAIFGVGRTRSRSICVAAGVDFSKKVKDLTDADLEKLREEVGKFVVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPMRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: UREG_PSEPK
Sequence: MQSYQQPLRVGVGGPVGSGKTALLEALCKAMRDHYQIAVVTNDIYTKEDQRILTEAGALEPERIVGVETGGCPHTAIREDASMNLAAVEALARKFGNLEVIFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITKSDFLVINKTDLAPYVGASLEVMERDTQRMRPQRPWTFSNLKKGEGLQAVIDFIVERGMLGVRG
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2398_YERPG
Sequence: MLCAIYRSPKRDQTYLYIEKKDDFSRVPAELLASFGKPQFAMLLALNERKTLATADVEKVKNALIEQGFYLQVPPPPESLLKMHLGETKA
What are the official names of this protein?
YcgL domain-containing protein YpAngola_A2398.
Protein: YWZG_BACSU
Sequence: MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMKEGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMDRILKWSGQNG
What are the official names of this protein?
Putative DNA-binding protein YwzG.
Protein: RS4B_CLOPS
Sequence: MAKMMGPRFKMCRRLGLNVVGHPKAMKRADRGTSRADKKLSDYGIQLLEKQRLRAYYGVMERQFTRYVDQAFNSKEQPGEALLMILESRLDNMVYRMGFASSIRQARQMVNHGHFLVNGKKVNIPSFRLNIGDEVVLREKSRKTEMFVNNFKDSIGSEVPYISKEEDNFKGIFARKPKREEIPITIQEQLIVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TOLB_HAEI8
Sequence: MKLLKRLVSVFAIVLAVGSNAFAGDEVRIVIDEGVDGARPIAVVPFVGSAPEDISKIVADDLRNSGKFNPIAVSQMPQRPTSAAEVNPEAWSNIGIDAIVIGQVVPSGNGYSITYQLIDTVGASGTPGAVLMQNSYTVTNKWLRYGAHTVSDEVFEKLTAIRGAFRTRIAYVVQKNGGSQPYEVRVADYDGYNQFIVNRSAQPIMSPAWSPDGQRLAYVSFENKKSQLVVQDLNSGARKVVASFQGHNGAPAFSPDGSRLAFASSRDGVLNIYVMGANGGTPTQLTSGAGNNTEPAWSPDGNSILFTSDRSGSPQVYRMDASGGSATAVGGRGSAQISADGKTLVMINGNNNVVKQDLTTGVSEVLSTSFLGESPSLSPNGIMIIYSSTQGLGKVLQLVSADGRFKASLPGSDGQVKFPAWSPYLTK
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TPIS_PLAFA
Sequence: MARKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDVVVFPVSVHYDHTRKLLQSKFSTGIQNVSKFGNGSYTGEVSAEIAKDLNIEYVIIGHFERRKYFHETDEDVREKLQASLKNNLKAVVCFGESLEQREQNKTIEVITKQVKAFVDLIDNFDNVILAYEPLWAIGTGKTATPEQAQLVHKEIRKIVKDTCGEKQANQIRILYGGSVNTENCSSLIQQEDIDGFLVGNASLKESFVDIIKSAM
What is the function of this protein?
Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.
What are the official names of this protein?
Triosephosphate isomerase, PfTIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
Protein: GPDA_NEOSM
Sequence: MVLMDSVVIGGGAWGTAIANLLAFNTQRVTIFCRNTTVIDSINKRHINTKYLPTFPLNKNISATSRMDVLKNAELIFVAVPSQSMRELLQKVKENIKESVQIILCNKGIERESLLLMSEVVHEELPKNDIFVLSGPNFAHEVLSKKPSFSNLAGRNKTSYDKIANALSTETFFTKYITDINGTQILGAFKNVIAIICGLLVRMDAGSNTLSALMSLALEEARSFITIKNGNPDTIMEFCGIGDLVLTCFSNKSRNFRYGYRLVDGYSENALVEGKSTLESLHELARIHNINCVLTNTLYTVTQFNSYGTSSFEQDIKRELNSAFMSLLGCAKNP
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARC_SALTO
Sequence: MARSDDADSRAARWEKEAHDLSTQVAFLQEELALVRRKLTESPRQVRQLEERLAAAQAQLARLTENNERLVSTLKEARAQIVTLKEEIDRLAQPPSGYGVFLARHDDGTVDVFTGGRKLRVAVSPSLEVADLRRGQEVLLNDALNIVDAFGYERAGEVVMLKEVLAGPDGAPGDRALVVSHSDEERVVHLAETLIDAPIRAGDSLMIEPRSAYAYERIPKSEVEELVLEEVPDVDYTDIGGLHAQIEQIRDAVELPFLHADLFREHQLRPPKGILLYGPPGCGKTLIAKAVANSLAKKIAERRGEEKHTSYFLNIKGPELLNKYVGETERHIRLVFQRAREKAGEGTPVIVFFDEMDSVFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFSKYILPGLPLHPDDLAEHDSDPQATVAAMIDAVVLRMYSETEENRFLEVTYANGDKDVLYFKDFNSGAMIQNIVDRGKKMAIKEFLTSARKGMRLQHLLDACVDEFRENEDLPNTTNPDDWARISGKKGERIVYIRTLVSGGKGADAGRSIETASNTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: UNG_ACIBC
Sequence: MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNALNITPLDHVKVVILGQDPYHGPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPVSRHGDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAVIDVLNEQREHIVFILWGAYAQRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_METCA
Sequence: MRDKIKLVSSAGTGHFYTTTKNKRTMPEKMEIKKFDPVVRKHVLYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: FARP1_HUMAN
Sequence: MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY
What is the function of this protein?
Functions as guanine nucleotide exchange factor for RAC1.  May play a role in semaphorin signaling.  Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
What are the official names of this protein?
FERM, ARHGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, FERM, RhoGEF and pleckstrin domain-containing protein 1, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1.
Protein: MINE_ACIF2
Sequence: MSFLDYFLGSRKKSANVAKDRLKLILAHERDADGPDFLPALQEELLAVIAKYIPVDKENIKVSMERRGDFEVLELNVLFPDQH
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: ETFB_ARATH
Sequence: MKILVAVKRVVDYAVKIRVKPDKTGVETQNVKMSMNPFCEIALEEALRIKEAGFAKEVIAVSIGPSQCVDTLRTGLAMGADRGIHVETNSIFLPLTIAKILKSLADVENPGLIFLGKQAIDDDCNQTGQMVAALLGWPQATFASKVVLDKDKNVATVDREVDGGLETLNVDLPAVITTDLRLNQPRYASLPNIMKAKSKPIKKMTVQDLKVDIKSDIEILEVTEPPKRKSGVMVSSVDELIDKLKNEAHVV
What is the function of this protein?
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase.  It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).  Involved in leucine catabolism and in phytol degradation.
What are the official names of this protein?
Electron transfer flavoprotein subunit beta, mitochondrial, Beta-ETF.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PLSY_RHORT
Sequence: MADLSTLMPALVLGVCALAGYLLGSVPFGLVLVRLAGLGDVRGIGSGNIGATNVLRTGRKDLALATLVLDSGKGAIAALVASALASRIAGFEDAVLAGLLAGGMAVVGHNFPIWLGFKGGKGVATTLGTLLATAWPVGLAACATWLVVAALFRYSSLAALVCLALAPAYALVLATPAHAAVFALLALLAWIRHRANIARLLKGEESRIGAKKKAAP
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SREC_MOUSE
Sequence: MLAAMGLELVFSLLLLWTQGTQGSTLDPAGQHVCKGSSPSELQCCPGWRQKDQECTIPICEGPDACRKEEVCVKPGLCRCKPGFFGAQCSSRCPGQYWGHDCRETCPCHPRGQCEPATGDCQCQPNYWGRLCEFPCTCGPHGQCDPKTGLCHCDPGWWSPTCRRPCQCNPASRCDQATGTCVCPPGWWGRRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQCSVTSGHCSCPPGFHGIRCELPCNPGHYGAQCKESCGHCELNATCSPVTGNCESCKPGWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDPGWLGHRCENPCPLGTFGKGCSSTCPACAQGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLGRHGKNALIVGILVPLLLLLMGIVCCAYCCSGTRLDPKDRPERNGAAFFRMKQQVWGALTNLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFVPPREEMVPMAQEESPEASLPGGSFPPPEDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPEGQEAEESTGPEQVNTEEDAPTATSSGDPATSHGQLPPGSQMVAECAETTDGGIQESSGSVATIYMLAGTPQKPEGPVWSVFRRLGNYQKDQMDPKVKSAIPKPLRRSLGRNQASAGSAPGAVLSQAMESTAVRPEETPRGLGDGIESSGTVQEPDAGGSSLEQDSQKQAEEKEQEEPLYENVVPMSVPPQH
What is the function of this protein?
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL).  Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity).  Plays a role in the regulation of neurite-like outgrowth.
What are the official names of this protein?
Scavenger receptor class F member 1, Acetyl LDL receptor, Scavenger receptor expressed by endothelial cells 1 protein, SREC-I.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HIS1_THEKO
Sequence: MRFVLPKGRLLKPSIEFLRKAGVELELPNGRELVSADGRVLLARAFDVPVYVEHGVEVGIAGSDVVLERGSDVFIPLELPFGKCRISVAVPGERKRYPEDMDCFRIATKYPRIASSYFDSIGVDVEVMKLHGSVELSVRTGIADAIVDIVETGQTLRENGLVEVAKVMDVSALLLVNRIAQKVLFDEINELVMKLRGVLDEGA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFB2_YEAST
Sequence: MSHHKKRVYPQAQVPYIASMPIVAEQQQSQQQIDQTAYAMGNLQLNNRANSFTQLAQNQQFPGSGKVVNQLYPVDLFTELPPPIRDLSLPPLPITISQDNIVTPSEYSNVPYQYVRSTLKAVPKTNSLLKKTKLPFAIVIRPYLHLQDSDNQVPLNTDGVIVRCRRCRSYMNPFVVFINQGRKWQCNICRFKNDVPFGFDQNLQGAPINRYERNEIKNSVVDYLAPVEYSVREPPPSVYVFLLDVSQNAVKNGLLATSARTILENIEFLPNHDGRTRIAIICVDHSLHYFYVPLDDDYEVSDEDDEESDGEEEDEDEEEEDVDNSETIQMFDIGDLDEPFLPMPSDELVVPLKYCKNNLETLLKKIPEIFQDTHSSKFALGPALKAASNLIKSTGGKVEVISSTLPNTGIGKLKKRSEQGILNTPKESSQLLSCKDSFYKTFTIECNKLQITVDMFLASEDYMDVATLSHLGRFSGGQTHFYPGFNATSLNDVTKFTRELSRHLSMDISMEAVMRVRCSTGLRATSFFGHFFNRSSDLCAFSTMPRDQSYLFGISIEDSLMAEYCYLQVSTLLTLNTGERRIRVMTLALPTSESAREVFASADQLAITDFMTQNAVTKALNSSMYSARDFITKSLEDILNAYKKEISMSNINSVTSLNLCANLRMLPLLMNGLSKHIALRPGVVPSDYRASALNRLETEPLHYLIKSIYPTVYSLHDMPDEVGLPDFEGKTVLPEPINATISLFERYGLYLIDNSAELFLWVGGDAVPELLIDVFNTDTISQIPVGKSELPLLNDSPFNERLRRIIGRIRENNDTITFQSLYIIRGPSINEPANLNSEKDMASLRLWVLSTLVEDKVLNCASYREYLQSMKTSINR
What is the function of this protein?
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus.  COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
What are the official names of this protein?
SED5-binding protein 2, SEC24-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein: IAA31_ARATH
Sequence: MEVSNSCSSFSSSSVDSTKPSPSESSVNLSLSLTFPSTSPQREARQDWPPIKSRLRDTLKGRRLLRRGDDTSLFVKVYMEGVPIGRKLDLCVFSGYESLLENLSHMFDTSIICGNRDRKHHVLTYEDKDGDWMMVGDIPWDMFLETVRRLKITRPERY
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin-responsive protein IAA31, Indoleacetic acid-induced protein 31.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFP_STRPI
Sequence: MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENELLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_FRATM
Sequence: MSFLTLKDVDLKDKKVLVRVDFNVPVKDGKVTSKVRIEAAIPTIQYILDQGGAVILMSHLGRPTESEYDSQFSLEPVAKALSEIINKPVKFAKDWLDGVDVKAGEIVMCENVRFNSGEKKSTDDLSKKIASLGDVFVMDAFATAHRAQASTYGVAKYIPVACAGILLTNEIQALEKALKSPKKPMAAIVGGSKISTKLSVLNNLLDKVEILIVGGGIANTFIKAEGFDVGNSLYEQDLVAEATEILAKAKALGVNIPVPVDVRVAKEFSENAQAIIKKVSDVVADEMILDIGPESQKIIAELLKSANTILWNGPVGVFEFDNFAEGTKALSLAIAQSHAFSVAGGGDTIAAIEKFGIKDQVSYISTAGGAFLEFLEGKKLPAIEILKEKAIR
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGLN2_RAT
Sequence: MDSPCQPQALNQALPQLPGSVSESLEPSRARMGVESYLPCPLLPSYHRSGASGEASAGNGTPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTKECQRLAAQGARPEAPKRKWAKDGGDAPSPSKRPWARQENQEAKGESGVGCDSGGGSSNSTTHSSGEASSRLREEAQPSAPERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEVEALKWGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGNYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAARDKYQLASGQKGVQVPVSQPATPT
What is the function of this protein?
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:15925519).  Target proteins are preferentially recognized via a LXXLAP motif (By similarity).  Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:15925519).  Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity).  Also hydroxylates HIF2A (By similarity).  Has a preference for the CODD site for both HIF1A and HIF2A (By similarity).  Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity).  Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity).  EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (By similarity).  Also regulates susceptibility to normoxic oxidative neuronal death (By similarity).  Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity).  Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity).  Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
What are the official names of this protein?
Prolyl hydroxylase EGLN2, Egl nine homolog 2, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROB_VIBVU
Sequence: MERITVNLAERSYPITIGAGLFEDSAHLSSLTAGQKVVVITNVTVAPLYADKILSLLQSLGCQASLLELPDGEQYKSLDTFNQVMSFLLEGSFARDVVVIALGGGVIGDLVGFSAACYQRGVDFIQIPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPKSVIIDTNCLKTLPEREFAAGIAEVIKYGIIYDAEFFTWLDEHLDALYSLDEQALTYAIARCCEIKAEVVAQDEKESGIRALLNLGHTFGHAIEAELGYGNWLHGEAVAAGTVMAARTAQLQGMIDQQQFDKIFSILSRAKLPVHTPESMTFDDFMTHMMRDKKVLSGKLRLVLPSSIGTAEVVADVPQEVIRQAIEDCRTIN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.