PharMolix/UniProtQA huggingface dataset:
Protein: KDM5C_HUMAN
Sequence: MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558).  Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.  Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.  Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.  Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, [histone H3]-trimethyl-L-lysine(4) demethylase 5C.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UFM1_HUMAN
Sequence: MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC
What is the function of this protein?
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677).  The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677).  Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526).  Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (PubMed:25219498).
What are the official names of this protein?
Ubiquitin-fold modifier 1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RS3_ACICJ
Sequence: MGHKVNPVGLRLGINRTWDSRWFAGADYASLLHDDLKLREHLLGRLSGAGVSKVLIERPAKKPRVTIYAARPGVVIGKKGQDIEVLKKELSSMAKADVSLNIVEIRKPEIDAALVAQNIAQQLERRVAFRRAMKRAVQSAMRLGAQGIRINCSGRLGGAEIARMEWYREGRVPLHTLRADIDFGVATAKTTYGTCGVKVWIFKGEIMAHDPMAQDRRAAEQAPQR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MIMD_MYCGD
Sequence: MSSMQFGAATEFSNRCGVTLMNTPIGRVVAEVMGAKEGVELTEYPSMIRVDGVKLLSFDYDELTDALGQEFDGSIFEEISSTHYGRMVHLDDKTMLFASPEDAAEYIGFDLTAQ
What is the function of this protein?
Effector component of the propane 2-monooxygenase multicomponent enzyme system which is involved in the degradation of propane via the O2-dependent hydroxylation of propane.
What are the official names of this protein?
Propane 2-monooxygenase, effector component, Propane 2-monooxygenase, coupling protein component.
What is the protein family that this protein belongs to?
Belongs to the TmoD/XamoD family.
Protein: NADA_BACC2
Sequence: MSILEKVQPIETMLPERYHKMSKEDMEKRVHEIKEKMGKMLFIPGHHYQKDEVVQFSDAAGDSLQLAQVAASNKDAKYIVFCGVHFMAETADMLTTDDQIVILPDMRAGCSMADMADIEQTERAWKELTKLFGDTMIPLTYVNSTAAIKAFCGRNGGATVTSSNAKQMVSWAFTQKERLVFLPDQHLGRNTAYDLGIPLDKMAVWDPHTDSLEYDGDIEEIQVILWKGHCSVHQNFTVKNIENVRKNHPDMNIIVHPECCYEVVAASDYAGSTKYIIDMIESAPSGSKWAIGTEMNLVNRIIQQHPDKEIVSLNPFMCPCLTMNRIDLPHLLWALETIERGEEINVISVDKQVTAEAVLALNRMLERV
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN799_HUMAN
Sequence: MASVALEDVAVNFTREEWALLGPCQKNLYKDVMQETIRNLDCVGMKWKDQNIEDQYRYPRKNLRCRMLERFVESKDGTQCGETSSQIQDSIVTKNTLPGVGPYESRMSGEVIMGHSSLNCYIRVGAGHKPYEYHECGEKPDTHKQRGKAFSYHNSLQTHERLHTGKKPYNCKECGKSFSSLGNLQRHMAVQRGDGPYKCKLCGKAFFWPSLLHMHERTHTGEKPYECKQCSKAFSFYSSYLRHERTHTGEKLYECKQCSKAFPDYSSCLRHERTHTGKKPYTCKQCGKAFSASTSLRRHETTHTDEKPYACQQCGKAFHHLGSFQRHMVMHTRDGPHKCKICGKGFDCPSSLKSHERTHTGEKLYECKQCGKALSHSSSFRRHMTMHTGDGPHKCKICGKAFVYPSVFQRHEKTHTAEKPYKCKQCGKAYRISSSLRRHETTHTGEKPYKCKCGKAFIDFYSFQNHKTTHAGEKPYECKECGKAFSCFQYLSQHRRTHTGEKPYECNTCKKAFSHFGNLKVHERIHSGEKPYECKECGKAFSWLTCFLRHERIHMREKPYECQQCGKAFTHSRFLQGHEKTHTGENPYECKECGKAFASLSSLHRHKKTHWKKTHTGENPYGCKECGKAFASLSSLHRHKKTH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 799, Zinc finger protein 842.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRDI_STAAR
Sequence: MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: PEPB_YERPA
Sequence: MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFRGPKGQRSVVWAELPANEKTELEQRLKIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGIYTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKERVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHALFSFDDELAQALLNSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSATYRKSAVDQWSAGATGLGVRTVANLLLAQAKQ
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_PHOLL
Sequence: MNNGKFGVLLVNLGTPDKPTTAAIRRYLAEFLSDKRVIDLSRFIWKPILYGFVLPFRSSRVAKLYQKIWTDEGSPLLVYGRRQQKLLAERLAGIPVELGMNYGSPSLEQAIDNLLKQNVEQLIVLPLYPQYSGSSSAAVFDGVSLVLQKYRTIPGMHFIRSYADHPAYISALKETIEQSFDKHGQPDRLLLSYHGIPQRFVDTGDIYAEQCKLTTRLLKQAINYPTEQVMMAYQSRFGREQWLTPYVDQTMKTLPNQGIKHIQVLCPGFSSDCLETLEEIKQLNKEMFLNAGGEKFEYIPALNDNASHILLLEELVNGFVRNRDE
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS22_XENLA
Sequence: MGNGMNKILTGLFLGNFKDARDVEQLHKNNITHILSIHDSARPMLEGMKYLCIPASDSPSQNLIQHFKDSIAFIHECRLKGEGCLVHCLAGVSRSVTLVVAYVMTVTDFGWEDSLSAVRGARTCANPNMGFQKQLEDFGKCEVHHFRTWLKDTYGESTFHDKDEAKQLLDKHKQQEAAESQNATSSGRQWNSHLTSLSSRSYSNYTTET
What is the function of this protein?
Activates the Jnk signaling pathway.  Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase 22.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SUMO6_ARATH
Sequence: MSTKSSSIHGRNEVKMEGEKRKDVESESTHVTLNVKGQDEEGVKVFRVRRKARLLKLMEYYAKMRGIEWNTFRFLSDDGSRIREYHTADDMELKDGDQIDALLPQESGFGPSTVFRV
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity).
What are the official names of this protein?
Putative small ubiquitin-related modifier 6, AtSUMO6.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: Y439_PYRHO
Sequence: MVLVLAEIITVGDELLTGNTVDSNSAYIAQRLTEKGFWVRRITTVGDDVKEIENAVREAISRKPEVLIISGGLGPTHDDVTMLGVANAIGRKLKLCEDCLERIKEFYEELHRKGLIDDPTLNEARKKMAYLPEGSEPLNNTEGAAPGAYVEYEGVKIFILPGMPREMKAMLESEVLPRLGERKFVQKKFLAEITDESKLAPILEDTIERFKVKIHSSPKGFGKYIGIIIFAEDDEVIGKVIRYIEGKGIKFREGW
What are the official names of this protein?
Protein PH0439.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: TRMB_LEIXX
Sequence: MEPAPLVRPRSYVVRGRKTDAQQRAIAEFWPAFGVDFAGGLLDLDALFGRTAPRTVEIGFGNGENLLALAERHPERDFLGVEVHGAGVGRVFAAMRERGLSNIRVIRHDAVEVFETGLSAGSVAEALLFFPDPWPKARHHRRRLVQPDVVRLLARALAADGVLRLATDWEPYADHMLAVLDAEPVLVNVAGPGAFIPRPEARPVTKFERRGEKLGHSIFDLEYRPLP
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RL4_RHIME
Sequence: MDLTVKTLEGKDAGKVSLSDAIFGLEPREDIIARVVRWQLAKRQQGTHKSKGRAEVSRTGAKMYKQKGTGRARHHSARAPQFRGGGKAHGPVVRSHAHDLPKKIRALGLRHALSAKLKAEDIIVIDDLVANEAKTKALAGAFASLGLTNALIIGGAEIEGNFKLAAQNIPNVDVLPVQGINVYDILRRGKLVLSKAAVEALEERFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ATPD_THEFY
Sequence: MQGVSRTSLTEVIRRLDDILPSANTATLGHELFEVVALLDQEHSLRRWLADPAGSPDSKSELVNSLLETKVSPATLLVVSDVVRAQWSRPRDLVDAVEQAAVLATVAEHASARELEGVEDELFRFGRIVAGQPELRAALTTDGASIEHKRTLVENLLSGKVSTATLTLVTEAVTRPRGRTLEQGLEHFSQLVAERAKHYIAVVRAAVPLSEAQQSRLQAALTRIYGRDIHLNIEITPEIVGGLSIRVGDEVIDGTIAGRIAEVRRRLAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CLPX_AQUAE
Sequence: MAVKVNKEFCSFCGKRQDEVLILIAGPNNTYICDECVEKCYQIVRENKKTSYNFELKDIPKPEQIKKILDEYVIGQERAKKILSVAVYNHYKRIKAKEAGLSLDDVELEKSNILLIGPTGSGKTLLARTLAKILNVPFAIADATSLTEAGYVGEDVENVLVRLLQACDYDVKAAQKGIVYIDEIDKIAKKSGINPSITRDVSGEGVQQALLKIVEGSVVNVPPQGGRKHPHQEFIQVDTTDILFICGGAFVGLEDIIKQRLGKSRVGFEAEIKKVDKEQDLLELVEPDDLIRFGMIPEFIGRFPVIATLRELTEDELVRILVEPKNALVKQYQKLFELEGVKLTFTEKALREIAKEAIRRKTGARGLRAIMEDIMADIMFEVPSLPGVKEVIIDENVVKNKEKPKLIFEQAV
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL11_ALIFM
Sequence: MAKKVEAYIKLQVAAGMANPSPPVGPALGQHGVNIMEFCKAFNAKTESIEKGLPIPVVISVYNDRSFTFVTKTPPAAVLLKKAAGVKSGSGRPNTEKVGTVTDAQLQEIAETKAADMTGADIEAMKRSIAGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: LEUD_BRUAB
Sequence: MDKFTKLTGVAAPLPIVNIDTDMIIPKDYLKTIKRTGLGKGLFAEMRFNEDGSENPDFVLNKPGYRKAQILVAGDNFGCGSSREHAPWALLDYGIRCVISTSFADIFYNNCFKNGILPIKVAQEDLDKLMDDASRGANATLTIDLETKQIHGPDGGTISFDLDDFKRHCLLNGLDDIGLTMEKAKSIDTFEAKNAEERPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RBL_ANTLU
Sequence: SVGFKAGVKEYKLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGAAVRAESSTGTWTTVWTDGLTSLDRYKGRCYHXEAVLGEEDQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPNAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVXPVASGGIHVWHMPALTEIFGDDXRXQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAVEGNEIIREASKWSPELAAACEVWKEIRFNFKAVDTLDPS
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUVB_ARTS2
Sequence: MADSSLVGGGEEPEERVIEAALRPKNLHDFVGQHRVRKQLSLVLEASRMRGRSADHVLLSGPPGLGKTTLSMIIAAEMNAPLRISSGPAIQHAGDLAAILSSLSEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDIVVGKGAGATAIPLELPPFTLVGATTRAGLLPGPLRDRFGFTGHLEFYSVEELELVLRRSAGLLDLKVNSAGFSEIAGRSRGTPRIANRLLRRVRDWALVHGIEQIDARTASAALDMYEVDKRGLDRLDRSVLEALITKFGGGPVGLSTLAIAVGEEPETVETVAEPYLVREGLLGRTPRGRIAMAPAWTHLGYAVPEGVFGQEALALFEVEDLGVEPVAEWLPNGQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: Y1535_COXB2
Sequence: MDRRLLEILACPICKGKLVYSQDEQELICRFDKLVYPIHDGIPVMLPDSTRPLIER
What are the official names of this protein?
UPF0434 protein CbuG_1535.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RL33_CORGL
Sequence: MARNDIRPIIKLKSTAGTGYTYVTRKNKRNNPDRISLMKYDPVVRKHVEFREER
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MMP20_HUMAN
Sequence: MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC
What is the function of this protein?
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP).  May play a central role in tooth enamel formation.  Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
What are the official names of this protein?
Matrix metalloproteinase-20, MMP-20, Enamel metalloproteinase, Enamelysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: GABT_MYCLE
Sequence: MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF
What are the official names of this protein?
4-aminobutyrate aminotransferase, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, Glutamate:succinic semialdehyde transaminase, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: MNTD_BACSU
Sequence: MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLGIVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVILLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVCYKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAAAHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPANGVITKKLRTLNMQKERAG
What is the function of this protein?
Probably part of the ABC transporter complex MntABCD involved in manganese import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Manganese transport system membrane protein MntD.
What is the protein family that this protein belongs to?
Belongs to the ABC-3 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FA83A_MOUSE
Sequence: MSRSRHVGKIRKRLEDVKNQWTRPARADFSDNESARLATDALLDGGPEAYWRALSQEGEVDFLSSAEAQYIQAQAKEPPDAPDSAGGAESGPRGLDSCSLQSGTYFPVASEGSEPALLHTWTLAEKPYLKEKSSATIYFQMDKHNNIRDLVRRCISRASQVLAILMDVFTDVEILCDILEAANKRGVFVCVLLDQGGVKLFQEMCDKVQISDIHLKNISIRSVEGEVYCAKSGRKFAGQIQEKFIISDWRFVLSGSYSFSWLCGHVHRNILSKFTGQAVELFDEEFRRLYASSKPLMGLKSPRLVAPFQPNKGPEAPNGRLSGTSDSASDRTSSNPFSSLSTGSNAHNQSLSTSSGPSSPLAPIPPTVPRLQPYHSTRRAVAPQPLLVPMRPHEGAPAPYSSLMAYRPTRLQLQQLGLVPRVTHPWRPFLQALPHF
What is the function of this protein?
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway.  Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR.  Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.
What are the official names of this protein?
Protein FAM83A.
What is the protein family that this protein belongs to?
Belongs to the FAM83 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_SYMTH
Sequence: MYLSTLQLGAFRNYDSLTIHFSPGLNVLYGDNAQGKTNLLEAIHFLATGRSHRTSRDPDMVQEGREELLARAAVVRRTGTIELELRCGLQTRKQLKINGIAERKIARLVGSLAVVLFSPDDLQLLKGPPSGRRRFLDLELSQISQTYLHHLMAYNRLVAQRNTLLKQPVIDEGLMAVYDEQLVETGAQLVVRRAEAVRRLSPIASRYHRMLAEDREDLELAYQSQGVGDDGAADLETVRRRLERELARLRSEERRRQVTLVGPHRDDVGFWVAGRDARLYASQGQQRTAVLALKLAELEFMSEEIGEPPLLLLDDVASELDPHRRHYLLSAVREGVQSFITCTDLEDLMVREWPADHRLFRVRAGTVVLDDRGLS
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_ECO81
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQSVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYT5_ARATH
Sequence: MGFIVGVVIGLLVGIAIIIGFVKLENSRSKLRSELANTVAAFARMTVEDSRKLLPPEFYPSWVVFSERQKLTWLNHHLTKIWPYVDEAASELIKASVEPVLEQYRPAIVASLTFSKLTLGTVAPQFTGVSVIDGDKNGITLELDMQWDGNPNIVLGVKTLVGVSLPIQVKNIGFTGVFRLIFRPLVEDFPCFGAVSVSLREKKKLDFTLKVVGGDISAIPGLSEAIEETIRDAVEDSITWPVRKVIPIIPGDYSDLELKPVGMLEVKLVQAKNLTNKDLVGKSDPFAKMFIRPLREKTKRSKTINNDLNPIWNEHFEFVVEDASTQHLVVRIYDDEGVQASELIGCAQIRLCELEPGKVKDVWLKLVKDLEIQRDTKNRGEVHLELLYIPYGSGNGIVNPFVTSSMTSLERVLKNDTTDEENASSRKRKDVIVRGVLSVTVISAEEIPIQDLMGKADPYVVLSMKKSGAKSKTRVVNDSLNPVWNQTFDFVVEDGLHDMLVLEVWDHDTFGKDYIGRCILTLTRVIMEEEYKDWYPLDESKTGKLQLHLKWMAQSIYRDS
What is the function of this protein?
May be involved in membrane trafficking.
What are the official names of this protein?
Synaptotagmin-5, NTMC2T2.1, Synaptotagmin E.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.