PharMolix/UniProtQA huggingface dataset:
Protein: ACT_TAESO
Sequence: MGDEEVQALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVGIQAVLSLYASGRTTGIVLDSGDGVTHSVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESAGIHESTFNAIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITSLAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AACA_ENTFA
Sequence: MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
What is the function of this protein?
Involved in resistance to gentamicin, tobramycin, and kanamycin.  Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region.  The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides.
What are the official names of this protein?
Bifunctional AAC/APH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the aminoglycoside phosphotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I66A0
Sequence: MDSNTVSSFQDILMRMSKMQLGASSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ARNT_YERPA
Sequence: MKLLKDSGAALLALFFVLVYLLPVNSRLLWQPDETRYAEISREMLQRGDWVVPYFMDIRYFEKPVAGYWFNNISQWIFGDSNFAVRFGSIFSTALSAVLVYWLATLLWRNRSTSVLATLIYLSFLLVFGIGTYAVLDPMISLWLTAAMVSFYLTLKAENWQQKVGAYALLGVACGMGFMTKGFLALAVPVIAVLPIVIQQKRIKDLVVFGPIAIVCAVLLSLPWALAIAQREPDFWNYFFWVEHIQRFAEASAQHKSPIWYYLPILCIGVLPWLGLLPGALFKGWRERATKPELFFLLSWVVMPLLFFSVAKGKLPTYILPCMAPLSLLMAAYATDCANNIRMRALKINGVINLLFGVACALVIVVIGLGLVKDIVAYGPQENQKVWLGVLAFAGWGVTGFITLRNNARNWRWAAACPLLFILLVGYLIPQQVVDSKQPQNFIKNNFSELSSSRYVLTDSVGVAAGLAWELKRSDILMFSEKGELTYGLAYPDSQDNYISNDDFPTWLAQARKEGDVSLVVQLAKNEALPAHLPPADKVNLMNRLALLWYQKTP
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPAM_WHEAT
Sequence: MEFSPRAAELTTLLESRMTNFYTNFQVDEIGRVVSVGDGIARVYGLNEIQAGEMVEFASGVKGIALNLENENVGIVVFGSDTAIKEGDLVKRTGSIVDVPAGKAMLGRVVDALGVPIDGKGALSDHERRRVEVKAPGIIERKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQMNSRGTNESETLYCVYVAIGQKRSTVAQLVQILSEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSSTALPVIETQAGDVSAYIPTNVISITDGQICLETDVFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSSKLELAQYREVAAFAQFGSDLDAASQALLNRGARLTEVPKQPQYEPLPIEKQIVVIYAAVNGFCDRMPLDRISQYEKAILSTINPELQKSFLEKGGLTNERKMEPDASLKESTLPYL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: SSUD_PSEMY
Sequence: MSLNIFWFLPTHGDGKYLGTAEGARAVDHGYLAQIAQAADRLGYGGVLIPTGRSCEDSWLVAASLIPVTQNLKFLVALRPGIISPTVAARQAATLDRLSNARALFNLVTGGDPDELAGDGLHLSHAERYEASVEFTRIWRRVLEGETVDYDGKHIQVKGAKLLYPPIQQPRPPLYFGGSSDAAQDLAAEQVELYLTWGEPPAAVAEKIAQVREKAARQGREVRFGIRLHVIVRETNEEAWAAADRLISHLDQDTIDRAQASLARFDSVGQQRMAALHGGKTDNLEVSPNLWAGVGLVRGGAGTALVGDGPTVAARVREYAELGIDTFIFSGYPHLEESYRVAELLFPHLDVAPPARPESRGYVSPFGEMISSDILPKAAAAS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: 216R_IIV6
Sequence: MKVTLLLLLIAVLLLLLIFMKVCKQKCIEGIEFEIKNNVKKSLDKKIKDKKSVSKIVDKYTTGLQNCYNVKNVSFDQFIDPESTNNLELKKCVGSLINVGVMKYWSDNLESKTIDNLNETMECMTKLPLNSNTTTRFPLRAAECAGERSWWKPDIFGTRN
What are the official names of this protein?
Uncharacterized protein 216R.
Protein: CSPL9_VITVI
Sequence: MSVLGVGPRTVTPHLRKGMMESSSGISLARAEAFLRLFAILVLVLTACLLGFDTQTKLLFSTIKKTATFRDLGALQVVVYVDSVAAGYNLLQLGRGFISAKLKGKLINVSYVTLPWVCFLLDQAAVYTVFSANTAALQASIIAVTGESSLQWMKVCNRYTRFCIQVGGALLSGYLASLLMVLLSSLSAFSLFRLYSPKQFHLLKPT
What are the official names of this protein?
CASP-like protein 2C1, VvCASPL2C1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRAM_I03A1
Sequence: MNPNQKIIAIGSICMVIGIVSLMLQIGNMISIWISHSIQTGNQRQAEPISNTKVLNEKAVASVTLAGNSSLCPISGWAVHSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTGTDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVDSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: ERPA_BURTA
Sequence: MNAVTESAATTEMPAPFVFTDAAADKVKQLIDEEGNPDLKLRVFVQGGGCSGFQYGFTFDEEVNEDDTVLNKNGVVLLVDAMSYQYLVGAEIDYKDDLNGAQFVIKNPNATTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: UBIB_NEIMA
Sequence: MKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALLKMMPQSSKLKNEPPAVRLRLALESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPPFDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHKARLHSGERVAVKVLRPNLLPLIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFHNSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFRDGFFHADMHPGNILVAADNRYIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHIESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLMRLFEVSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWMNGQVGPKALWRNLKNEAPDWAQIIPSLPRKISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRAY_BLOPB
Sequence: MLFWLTENVLALYSSRFNIVCHLTFRAIISFLSALFISLGIGHCVITWFHNLCFFQIVRCDGPKSHTQKQSTPTMGGIVLILSIVISVMVCADLSNIYVWYVFFILITYGILGLTDDILKIKKKSSKGLSVLHKYFWQSLIALTLVIIIFMSDRSLTSTQLIVPFFKNFMPQLGIWYIFLAYFVVVGTSNAVNLSDGLDGLAIMPIMFVAAGLAVVAWISNDIHFASHLNIPYICFSGELIIICSAIIGAGLGFLWFNTYPAQIFMGDVGSLSLGGTLGIIAVLLHQECLLLIMGGMFVIETLSVILQVIYFRLFGQRIFKMAPIHHHFELKGCPEPRIIVRFWIISLMLVFVGLITLKIRQ
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PP155_ARATH
Sequence: MSTSILRRILDPTRKPKPDAILSISLLTTVSSPPSPPSDPLISDAVSILTHHRSKSRWSTLRSLQPSGFTPSQFSEITLCLRNNPHLSLRFFLFTRRYSLCSHDTHSCSTLIHILSRSRLKSHASEIIRLALRLAATDEDEDRVLKVFRSLIKSYNRCGSAPFVFDLLIKSCLDSKEIDGAVMVMRKLRSRGINAQISTCNALITEVSRRRGASNGYKMYREVFGLDDVSVDEAKKMIGKIKPNATTFNSMMVSFYREGETEMVERIWREMEEEVGCSPNVYSYNVLMEAYCARGLMSEAEKVWEEMKVRGVVYDIVAYNTMIGGLCSNFEVVKAKELFRDMGLKGIECTCLTYEHLVNGYCKAGDVDSGLVVYREMKRKGFEADGLTIEALVEGLCDDRDGQRVVEAADIVKDAVREAMFYPSRNCYELLVKRLCEDGKMDRALNIQAEMVGKGFKPSQETYRAFIDGYGIVGDEETSALLAIEMAESLKLRAEEES
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g15980.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: NDC80_NEUCR
Sequence: MSQDSNAGLWSVRRPRETLHGVNLTSGIPAPPSTLKRQSTIGTIGTGHGRSLSGRQSLALPRPSQPLFQRSSDIGLGSVKRASVHNMNTSQFKPYGTPGSSGIPRSSQELDRRSSVYRPSARPSAVGGGPLAGGHMSFFQQAPQPAGVPRDPRPLKDRQFQNRIGQELLEYLAKNNFEMEMNHKLSDNFTKSPTQKDFNYLFQWLYHRIDPSYRFQKNIDQEVPPLLKQLRYPYEKSITKSQIAAVGGQNWSTFLGLLHWMMQLAQMLEGYARHQYDDACMEAGVDIAGDQIIFDFLTSAYQDWLNMDDEAGDEDVERALQPHVQGMAEAFERSNAKYIQELEILEGENARLLKEIQELEKSTPDPAILDNHFKIMEEDKIKFEEYNTLAMQRTEKYENRIQVLREELGKLHVELKEAEEERRQMQKAVDDQGISMQDIDRMTSERERLQRSIESASQRLEDVKKKVAEREMEASQRLDELERLVEKYNTVAYQIGLIPATAVNAKGKNLELQVTVNEGTPNFASSMQGVLGPNGQPLGGVENERLLADSTTGYQPAHILNLDLRGQVKNTFLALRKEVSERRKVAMDVMMEDHDLLDRAKEAIEDKRNEVEALGHRVRAAEEEYEKTKEVTNAQKMASDAQIEKMEKELAKMRAQLSESVQLMEQREMNTNIEYEQLTLRANALREELHTETMRMLNDVIKFKMHVQRSLEEYETFVADELEQELGIDDQEMEDEDTPMADV
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein ndc80, Kinetochore protein 1.
What is the protein family that this protein belongs to?
Belongs to the NDC80/HEC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: RNS3_ARATH
Sequence: MKFFIFILALQQLYVQSFAQDFDFFYFVLQWPGAYCDSRHSCCYPQTGKPAADFGIHGLWPNYKTGGWPQNCNPDSRFDDLRVSDLMSDLQREWPTLSCPSNDGMKFWTHEWEKHGTCAESELDQHDYFEAGLKLKQKANLLHALTNAGIKPDDKFYEMKDIENTIKQVVGFAPGIECNKDSSHNSQLYQIYLCVDTSASKFINCPVMPHGRCDSRVQFPKF
What is the function of this protein?
May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting.
What are the official names of this protein?
Ribonuclease 3.
What is the protein family that this protein belongs to?
Belongs to the RNase T2 family.
Protein: AFCA_ASPNC
Sequence: MLISGSSAALCALALPFAAAKSLWSDSPGNYSSFITTAFPLGNGRLGAMPIGSYDKEIVNLNVDSLWRGGPFESPTYSGGNPNVSKAGALPGIREWIFQNGTGNVSALLGEYPYYGSYQVLANLTIDMGELSDIDGYRRNLDLDSAVYSDHFSTGETYIEREAFCSYPDNVCVYRLSSNSSLPEITFGLENQLTSPAPNVSCHGNSISLYGQTYPVIGMIYNARVTVVVPGSSNTTDLCSSSTVKVPEGEKEVFLVFAADTNYEASNGNSKASFSFKGENPYMKVLQTATNAAKKSYSALKSSHVKDYQGVFNKFTLTLPDPNGSADRPTTELLSSYSQPGDPYVENLLFDYGRYLFISSSRPGSLPPNLQGLWTESYSPAWSGDYHANINLQMNHWAVDQTGLGELTEPLWTYMAETWMPRGAETAELLYGTSEGWVTHDEMNTFGHTAMKDVAQWADYPATNAWMSHHVWDHFDYSQDSAWYRETGYPILKGAAQFWLSQLVKDEYFKDGTLVVNPCNSPEHGPTLTPQTFGCTHYQQLIWELFDHVLQGWTASGDDDTSFKNAITSKFSTLDPGIHIGSWGQIQEWKLDIDVKNDTHRHLSNLYGWYPGYIISSVHGSNKTITDAVETTLYSRGTGVEDSNTGWAKVWRSACWALLNVTDEAYSELSLAIQDNFAENGFDMYSGSPPFQIDANFGLVGAMVQMLIRDSDRSSADASAGKTQDVLLGPAIPAAWGGGSVGGLRLRGGGVVSFSWNDSGVVDSCKADLSARGSDVSQVKFYVAGGRAIDCSS
What is the function of this protein?
Alpha-fucosidase involved in degradation of fucosylated xyloglucans.  Hydrolyzes alpha-1,2-linked fucose (By similarity).
What are the official names of this protein?
Probable alpha-fucosidase A, Alpha-L-fucoside fucohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 95 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL15E_METST
Sequence: MRCYIMYKYMKEAWKNPDESYVKELMRERLPKWRRQPVIIRIDKPTRIDRARRLGYKAKTGYVVARIRVRRGSRRKSRFKNGRDPKRMGVNKISGEKSIQRMAEERVARKYPNLEVLNSYWVWEDGKAKYYEVILVDPQCPSIQHDNKINWICSKKHTRRAFRGLTSAGKKGRGLNKKGKGAEKVR
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: ICCC_TALVA
Sequence: MITLQNLPWILLYTGFLAIFLSRLFSNGKQSRDEKANGCQPPARYPQWDPIMGLDLVYSQVSALKNNRYLEWLRDLHAKMPKTFSLNFFGQRWIYSIEPEILKAVYATNFRDFGVEPIRRHSKGSMPFADKGVNTTDGEDWEFSRLLIKPFFERNVYTDTDRIKVHADHFLSLIPADGETFDAQPLVQRWFLDLTTEFIFGESMGSLAHPERADIAWTMLDVLRGGRLRAQMHRFMWARDWTWWLKAVYKVHDYVNPYIRSTLKELAEREERIKQGLPVGPERTDLVWSMATHLRDEELLRSQLCLIIVPNNDTTSIFISNCLWHLARHPEVWKKLREEVFALGEETPLTFEILRNMKYLNGVLNETHRVIPNNVTQVRACVQDTVLPVGGGPDGKWPVQVRKGDIVSVTKTVMYRDPDYWGSDADEFRPERFDGLRGTWNFLPFGGGPRRCPAQMMSQTEAAYMLCRLARTYSRIEARDPEPYTAVMRIGPSNKTGVKIALYK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:30905148).  IccC catalyzes the ring expansion of the tetramate intermediate to the acyclic 2-pyridone intermediate that contains the trans bis-diene chain (PubMed:30905148).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization.  IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (PubMed:30905148) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase iccC, Ilicicolin H biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NEP_I96A3
Sequence: MDSHTVSSFQDILMRMSKMQLGSSSGDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQHRNGKWREQLGQKFEEIRWLIEEVRHKLKTTENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: GLMP_PONAB
Sequence: MRGSVERGWGWGHCASSPLLLWTLLLFAAPFGLLGEKTRQLSLEVIPNWLGPLQNLLHIRAVGTNSTLHYVWSSLGPLAVVMVATNTPHSTLSVNWSRLLSPEPDGGLMVLPKDSIQFSSALVFTRLLEFDSTNVSNTAAKPPGRPYPPYSLADFSWNNITDSLPATLSATFQGHPMNDPTRTFANGSLAFRVQAFSRSSRPAQPPRLLHTADTCQLEVALVGASPRGNHSLFGLEVATLGQGPDCPSMQEQHSIDDEYAPAVFQLDQLLWGSLPAGFAQWRPVAYSQKPGGRESALPCQASPLHPALAYSLPQSPIVRAFFGSQNNFCAFNLTFGASTGPGYWDQHYLSWNAPGCGLPSSGRLVPTSPGHHGSALGAPGLMLLGGGLVLLLHHRKYSEYQSIN
What is the function of this protein?
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
What are the official names of this protein?
Glycosylated lysosomal membrane protein, Lysosomal protein NCU-G1.
What is the protein family that this protein belongs to?
Belongs to the GLMP family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Protein: FB154_ARATH
Sequence: MMSNLPLDLVEEILSRVPATSLKRLRSTCKSWNNCYKDQRFTEKHSVIAAKQFLVLMLKDCRVSSVSVNLNEIHNNIAAPSIELKGVVGPQMQISGIFHCDGLLLCTTKDDRLEVWNPCTGQTRRVQHSIHYKTNSEFVLGYVNNNSRHSYKILRYWNFYMSNYRVSEFEIYDFSSDSWRFIDEVNPYCLTEGEVSLKGNTYWLASDEKRDIDLILRFDFSIERYQRLNLPILKSDYETEALSVVREKQLSVLLKRNDTLEREIWVTTNDKIDHTTKNLLWIKFLAIDQRTCYHWSCVSFFIDEEKKMAVFCDGYIGGINETSRRMFYIIGEDKYYRELYVGDSPIRSHRPFVFNYVPSLVQIPQATVIPKRRRRKRKNRN
What are the official names of this protein?
Putative F-box protein At3g17500.
Protein: MIAA_BUCAT
Sequence: MGPTACGKSQLAICLRKYLSIELISVDSALIYRGMDIGTDKPSFSDLYNHPHRLLNIKDPVENYSAAEFQKDVLREIDEIIKLGKIPCLVGGSMFYYNVLLHGLSILPPSNIKLREYLIQKSYEKNYLYKKLKLIDPISASRIHKNDFQRLIRALEIFYLSGKSLTELKKKNNYKLPYNIFQFAIIPPNKEWLNNKIELRIKKMLMLGFQKEVEILFLRGDLHKNLPSIRCIGYRQMWEYLEYKNSYKDMFNKTIHATRKLAKHQLTWLKNWKNINKIEYHSTSTILAKKVLDVLEKNDFSV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GDF8_CAPHI
Sequence: MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.