PharMolix/UniProtQA huggingface dataset:
Protein: YAEP_SALCH
Sequence: MEKYCELVRKRYAEIASGDLGYVPDALGCVLKVLNEVAADSALSESVREKAAYAAANLLVSDYVNE
What are the official names of this protein?
UPF0253 protein YaeP.
What is the protein family that this protein belongs to?
Belongs to the UPF0253 family.
Protein: SNW1_MOUSE
Sequence: MALTSFLPAPTQLSQDQLEAEERARSQRSLQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDPEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKEPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPIDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRKQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  Required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA.  May recruit PPIL1 to the spliceosome.  May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.  Involved in transcriptional regulation.  Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1.  Is involved in NOTCH1-mediated transcriptional activation.  Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
What are the official names of this protein?
SNW domain-containing protein 1, Nuclear protein SkiP, Ski-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the SNW family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_CAMJ8
Sequence: MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLADIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLGLPILGICYGMQLMAHHYKATVAPAGHKEYGKANIEVKKDSALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGSDKVLCAVSGGVDSSVVAALLASAIKEQVIVVFVDNGLLRSGEKEQVEFMFKNTLGIDLISIDASEIFLSRLANVRDPEQKRKIIGNTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPSLELLRKADVILLEELKSTGWYDKTWQAFCVLLNIKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLENISRRIINEVEGINRVVYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: TRIM5_NOMLE
Sequence: MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKTSMPDEGERSCPVCRISYQHKNIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCREDRKVICWLCERSQEHRGHHTFLTEEVAQEYQVKLQAALQMLRQKQQEAEELEADIREEKASWKTQIQYDKTNILADFEQLRHILDWVESNELQNLEKEEKDVLKRLMKSEIEMVQQTQSVRELISDLEHRLQGSVMELLQGVDGVIKRMKNVTLKNPETFPKNQRRVFRAADLKVMLKKLRELRDVQHYWVDVTVAPNNISYAVISEDMRQVSSPEPQIIYEAQGTISQTFVNFNYCTGIRGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDAMYNIEQNENYQPKYGYWVIGLEERVKCNAFQDGSFHTPSAPFIVPLSVNICPDRVGVFLDYEACTLSFFNITNHGFLIYKFSHCSFSQPVFPYLNPRKCTVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: CEL1_AGABI
Sequence: MRLPSRQQVLKMLATFSLALGLFAAKVQAHGGVIGYSWDGTWYEGWHPYNTPVGQTSIERPWATFDPIMDATASTVGCNNDGNPGPNQLTATVAAGTAITAYWNQVWPHPYGPMTTYLGKCPGSSCDGVNTNSLKWFKIDEAGLLSGTVGKGVWGSGKMIDQNNSWTTTIPSTVPSGAYMIRFETIALHSLPAQIYPECAQLTITGGGNRAPTSSELVSFPGGYSNSDPGLTVNLYTQEAMTDTTYIVPGPPLYGSGGNGGSPTTTPHTTTPITTSPPPTSTPGTIPQYGQCGGIGWTGGTGCVAPYQCKVINDYYSQCL
What is the function of this protein?
Probable glycosyl hydrolase active on cellulose.
What are the official names of this protein?
Cellulose-growth-specific protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 61 family.
What are the subcellular locations of this protein?
Secreted.
Protein: 6PGD_STAAW
Sequence: MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFVNSLEKPRKILLMVQAGKATDATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAAKAKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMKLDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKELNGPKASFDGDKKDFLEKIRKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQDALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: SPEE_ECODH
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAIHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_SHEPW
Sequence: MSDQLFERTMAFAGILQAVAQVQYIARHGDSDKDALAASLNSVLVTNPDSTSEVYADKEALKKGYQMIVAQLGDGKQKDVEVTRYLVGILALERKLARSANAMGMLSERINQIHRQLSHFEITDEQVIANFAGIYSDIVSELGPKLQISGNPEFLKRTQTQQKIRALLLSAMRSAVLWRQLGGKRRHLVFARKTIVDTAMKSLTL
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KAD_AZOPC
Sequence: MLNIGIFGAPGSGKGTQSELISEKYSLYPISTGEILRREIKDKTELGKIAEEYINQGQLLPDYLTIRILVDLFDKVDNNKGYIFDGFPRTISQAKALDDLLKEQNTSIAIVFSLSVDEKELIRRLLKRGKLFSRKDDNLETIQNRLTVYREQTESVQEYYRKKGKLMEIIGKNSVEEVFENIVEKIDNLFR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_LEIXX
Sequence: MSKRTFQPNNRKRAKTHGFRLRMRTRAGRAILSARRAKGRQKLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RPO11_KORCO
Sequence: MEIEVVDVSRNEIRVLIRGETHTLLSPLVEELNSLDEVEFAGYDVPHPLKEESVLFLRVKEGMNPREVLKGAIRRLMEKYEIIGNSFIEELSSLKVNH
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_AZOPC
Sequence: MNTFGNIFKLTSFGESHGTAIGGVIDGCPAGIVLDMEFVQGELDKRRPGQSELTTSRNESDKVEFLSGIYEGKTIGTPIGFIVWNNNQHSSDYDSLKNVFRPSHADYTYFQKYRHYDHRGGGRSSARETIARVVAGAIAKLILQKKGIKITAYVSQVGDICLSKSYIQVDFSNIEKTAVRCPDLEIAKQMIALIQSVRLRGDTVGGVITCICHGVPVGLGNPVFGKLSAALSNAMMSINATKGFDYGMGFNGIHRKGSEANDLYYRNKDGKIVTKSNYSGGIQGGISSGEDIYFRVAFKPVATLLQGQLTVDKDGNEIQLEVKGRHDPCVLPRAVPIVESMAAMTILDYYLYNY
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: HEPA_PSHV1
Sequence: MRMRSLSAASSGYNGDPRGLGLERLKTVVRGKLRPSGSEIEWLWPSDQNNTASPAGAKTDQPTSAPRFFLTREATVFGPSWKPASRQIVASVLPVTGEMVMVSAERFSCMALFAVFLKLYRGFYMKPVAPCATHVRRPIMLAQFPVFDSRPSHGPQEQSGSHEPLARAAAQRRTKHNFLFMPGFPCLACVPISASAERHDRAMAACRAASLTEHLWPAYGIRALHMLNRTPAAASITRAVARRSRLLTADLTRSLETFPAGTITCAAGAPMIFSDCRLARLDFSAFYPCLYAAYVGKHRGLTKILHERLRRRAGSEDLKPALVTMFGGLRHVDANGYRFVVGASNIIAKAVEQTANRMGFGVAAYVKDGFWGAFDSSSKTTAEELRAECEKAANATLARLVVDKDGAGEPPVSLVLRLEGVYTDGLLINANKYWLFNSESGDSFICGVMGGHERSGLSRETTAAADDILKKIKASAKSIDDVEAIARSRIDAWIYAIFGHRGDVEFWAEQTPGDKDFLIPEEIRTTTVGKLEAADSCLGGELSYVFIPKNTQDTGAAKTKGGGARGWHSAPAAAFPCSLVEDVFCIKINYEAHLLPRLEGLLAWSRIYAWLQFRNQIPLADDEDESTTQAKETARIDYNYGDVSFLFA
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs.  The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
What are the official names of this protein?
DNA helicase/primase complex-associated protein, HEPA, Primase-associated factor.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HEPA family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PYRF_MYCLE
Sequence: MTGFGARLVEATSRRGQLCLGIDPHPELLRAWDLPTTADGLAAFCDICVEAFSGFAIVKPQVAFFEAYGAAGFAVLEYTIAALRSVGVLVLADAKRGDIGSTMAAYAAAWAGNSPLAADAVTASPYLGFGSLRPLLEVAAAHDRGVFVLASTSNLEGATVQRATFDGRIVAQLIVDQAAFVNREMNRSFHRSEPGCLGYVGVVVGATVFGAPDVSALGGPVLVPGVGAQGGHPEALGGLGGAAPGQLLPAVSRAVLRAGPGVSELRAAGEQMRDAVAYLAAV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: BRK2_BOMOR
Sequence: MRLWFCLSFFVVLCLEHFPGTLADERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHIPRNVPESEEKTEQFLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDMYEIKGFKSAHGRPRVCPPGEQCPIWVG
What is the function of this protein?
Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle.  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Kininogen-2, BOK-2.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDH_LEPPG
Sequence: NSELINSILGLPKVMNDA
What is the function of this protein?
Causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas.  May also function as a neurotransmitter and/or neuromodulator.
What are the official names of this protein?
Pigment-dispersing hormone, PDH, Beta-PDH, Light-adapting distal retinal pigment hormone, DRPH.
What is the protein family that this protein belongs to?
Belongs to the arthropod PDH family.
What are the subcellular locations of this protein?
Secreted.
Protein: YHJR_BACSU
Sequence: MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAHSDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER
What are the official names of this protein?
Uncharacterized protein YhjR.
Protein: ARLY_POLAQ
Sequence: MSSSKNSLANKAQAWSARFTEPVDELVQRYTASIGFDQRFAMVDIAGSLAHAEMLATQKIISAQDLADIQKGMAQIKSEIEAGQFEWQLALEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDLRLWLRASVDDISVTLKSLRIALLDLAEKHASTIMPGHTHLQVAQPITFGHHLMAYYEMFSRDASRLVDLRARFNRLPLGAAALAGTTYPIDREQVARILGFDGICNNSLDAVSDRDFAIEFCAFSSILMMHVSRLSEELVLWLSPRFGFIDLPDRFCTGSSIMPQKKNPDVPELARGKTGRVYGDLISLLTLMKSQPLAYNKDNQEDKEPLFDAVDTVQDTLRIFADMVPHIEVKAEVMKAAAEEGFATATDLADYLVKKGLAFRDAHEAVAHAVKACVGRNCMLTDLSLAELRFACGLDNRPELMSDDVFALLTVDGSVQSRQHAGGTAPAQVLAAIKRARTDL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BURVG
Sequence: MGQKIHPTGFRLAVSRNWASRWYANNNNFAAMLQEDIGVREYLKKKLKNASVGRVVIERPAKNARITIYSSRPGVVIGKKGEDIEQLKTELQRRMGVPVHVNIEEIRKPETDAQLIADSITQQLERRIMFRRAMKRAMQNAMRLGAQGIKIMSAGRLNGIEIARTEWYREGRVPLHTLRADIDYATSEAKTTYGIIGVKVWVYKGDTLGRNDAPVVEEVAEDKRPRRNARPGDRRPRRDGEGGAPGARRGAPRRGAGKPEDGKTGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ATG18_NEOFI
Sequence: MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFNPPSHTPPGSTHVSPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSHPTSSPDASPSSPVGRDRSLSQSSSGYSPDRGDLTGDVGSSDFPARKHNGTLMGMIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPTRDFAWFKLPKPNQTSGGSVNNGPLRSVVAMSSNTPQVMVVTSDGNFYVFSIDLSKGGEGTLTKQYSVLESNDRLGYSVTDY
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Necessary for proper vacuole morphology.  Plays an important role in osmotically-induced vacuole fragmentation.  Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy.  Involved in correct atg9 trafficking to the pre-autophagosomal structure.  Might also be involved in premeiotic DNA replication (By similarity).
What are the official names of this protein?
Autophagy-related protein 18.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: RPOB_GEOUR
Sequence: MAYSIANNPLLRKNFAKIKKIIEIPNLIDIQKNSYKRFLQLDVPAEARKYSGLEAVFKSVFPIKDFSETASLEYVSYSLGIPKYDVEECHQRGMTFAAPMKVKVRLVVWDVNKEPSTRSIRDIKEQEVYFGEIPLMTENGTFIINGTERVIVSQLHRSPGVFYDHDKGKTHSSGKVLYSARVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSTDKLLNFFYKSEEIFFEGDKLMKIADPELLTNQKAVVDIVDPNTGEVLVKANRKFTKAAIRKMAEHGIKYIPITIEEVLGKVASHDIVDPATGEVLAECNEELTQVKIDEIKGRGIATFKVLFIDNLHVTSSLRDTILIDKIGSTDDALIEIYRRLRPGDPPTLKSALALFENLFFNPERYDLSAVGRLKLNYKLGLQIPLDCMTLTREDVLEVVRYLIDLKNGKGSIDDIDHLGNRRVRAVGELLENQYRIGLVRMERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPYRLVKEGKVTTEVRFFSALEEEGHAIAQANAEVDSDGRFVADYISARKSGEFVLVGRDELELMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARDSGVSVVARHNGVVESVDASRIVVKIDEDEYDETGTGVDIYNLIKFARSNQNTCINQRPVVKIGDHVKRSDVIADGPSTDMGELALGQNVLVAFMPWGGYNFEDSILISERLVKDDRYTSIHIEEFECVARDTKLGKEEITADIPNLGEETLKDLDESGIIRIGAEVRPGDILIGKITPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTELIEKAEEQKLRKDEQDEIRIIRESAVGKLKKLLVGKTAAVKFEGKDGKVLIVKGKAITEEALLSVPVDRWDEISIADDDTVDEKVAQILGTLNQQIDIIKYVFDDKIQKLKRGDDLPPGVIKMVKVYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYLEDGRPVEIVLNPLGVPSRMNVGQILETHLGWAAKGIGWQIEDMLEKNSPQNQIKTYLKEVYGNKEMNKFLDSLEEEELNNVAKRLKRGVPMASPVFEGASEQGIQEMLGKAGFEYTGQVTLYDGKSGVAFKHKVTVGIMYVLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRLGEMEVWAMEAYGAAYALQEFLTVKSDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLGLDVELLENEEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PYRD2_KLULA
Sequence: MNSGFPRILSKKLFTLNQSQFFVKNGMVPLKAGISGPKLLKYTVGIAIGSFAGFYFSNSRSAFHEYVLCPMLRLVTPDAEDGHKLGIWFLKNGLAPRLWFDNDDKVLNVNIFGKKLTNPIGCAAGLDKNGDAIDGILSGGFGYIEIGSVTPLPQPGNPRPRFFRLPLDDAVINRYGFNSSGHDTVVNTLQSRITSFINSYMFKDNSVENLSLYKDKLLGVNLGKNKTGDEVQDYLKGVESFQKYADVLVINVSSPNTPGLRSLQKESILTDLLTQVVAKRDSLVTSGNALGAKTHKPPVLVKVAPDLVEEEIKSIAEAAKKSKVDGIIISNTTIQRPTTLITEDSDLVSQAGGLSGKPLKPLALKALKTMAKYTKGSGLVLVGCGGISSGADAIEFAKAGASMVELYTAYAYKGPGLIAKIKDETTELLKKENKTWSEIIGEDIK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOD, DHODase, DHOdehase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PIWL4_MOUSE
Sequence: MSGRARVRARGITTGHSAREVGRSSRDLMVTSASPGDSEAGGGTSVISQPYELGVSSGDGGRTFMERRGKGRQDFEELGVCTREKLTHVKDCKTGSSGIPVRLVTNLFNLDLPQDWQLYQYHVTYSPDLASRRLRIALLYNHSILSDKAKAFDGASLFLSEKLDQKVTELTSETQRGETIKITLTLTSKLFPNSPVCIQFFNVIFRKILKNLSMYQIGRNFYKPSEPVEIPQYKLSLWPGFAISVSHFESKLLFNADVNYKVLRNETVLDFMTDLCLRTGMSCFTEMCHKQLVGLVVLTRYNNKTYRIDDIDWSVKPTQAFQKRDGSEVTYVDYYKQQYDITLSDLNQPVLVSLLKRKRNDNSEPQMVHLMPELCFLTGLSSQATSDFRLMKAVAEETRLSPVGRQQQLARLVDDIQRNPVARFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLSSQPLNRWLIVCCNRAEHLIEAFLSCLRRVGGSMGFNVGYPKIIKVDETPAAFLRAIQVHGDPDVQLVMCILPSNQKNYYDSIKKYLSSDCPVPSQCVLTRTLNKQGTMLSVATKIAMQMTCKLGGELWSVEIPLKSLMVVGIDICRDALNKNVVVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNRWYRHNHDLPARIVVYRDGVGNGQLKAVLEYEVPQLLKSVTECGSDARSCRLSVVVVRKRCLLRLFASTDHTVQNPPLGTVVDSEATRPEWYDFYLISQTANRGTVSPTHYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGLISVPAPCQYAHKLTFLVAQSVHKEPSLELANNLFYL
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:26669262, PubMed:22020280).  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:26669262, PubMed:22020280).  Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.  Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:26669262, PubMed:22020280).  The piRNA process acts upstream of known mediators of DNA methylation (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:26669262, PubMed:22020280).  Does not show endonuclease activity (PubMed:22020280).  Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (PubMed:22020280).  In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities.  Plays a role in pancreatic beta cell function and insulin secretion (By similarity).  Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (By similarity).
What are the official names of this protein?
Piwi-like protein 4, mAgo5.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization.
Protein: PEPB_ECO55
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASASQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.