PharMolix/UniProtQA huggingface dataset:
Protein: LEUD_ECOBW
Sequence: MAEKFIKHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPDFVLNFPQYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVKLSDAEVDELFALVKANPGIHFDVDLEAQEVKAGEKTYRFTIDAFRRHCMMNGLDSIGLTLQHDDAIAAYEAKQPAFMN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: PIHD1_BOVIN
Sequence: MADSKMLVPELNDAETMGAETSRFEELLLQASKELQQAQTSRPESTQIQPQPGFCIKTNSAEGKVFINICHSPSIPPPADLTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFFRRMQNSDFLRELVITIAREGLEDKYGLQLNPEWRILKNRPFLGSISQQNIRSQQRPRIQELGNLHTPSSPRPEAGPEKPHLSLWLEAPDLLLAEIDLPKLDGALGLSLEVGENRLVMGGPQQLYHLDTYIPLRINCDESKAAFHQKRKQLMVAMPLLSVPS
What is the function of this protein?
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity).  Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity).  Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity).  Positively regulates the assembly and activity of the mTORC1 complex (By similarity).
What are the official names of this protein?
PIH1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXH_CHRVO
Sequence: MAIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPLAAMRDFAAQTPLYVMRGNRDFLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTDDAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSEMNKQQTGLTDISDVTENAVRELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: T53I1_RAT
Sequence: MFQRLNKMFVGEVTTSSSHEPEFSEKEDDEWILVDFIDTCTGFSAEEEEEDEDIGEESSAEHTSVFSCLPTSLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDDYNSSGPRMEAQSELGTHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDCHTRQMKHRCWAVHQPCPRQYNY
What is the function of this protein?
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy.  Acts as a positive regulator of autophagy.  In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy.  Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response.  Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function.  Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle.  In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.  Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism.  Can reduce cell migration by regulating the expression of SPARC (By similarity).
What are the official names of this protein?
Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, Thymus-expressed acidic protein, TEAP, p53-dependent damage-inducible nuclear protein 1, p53DINP1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Protein: RAPA_PSEF5
Sequence: MAQQYQPGQRWISDSEAELGLGTVLAQDGRLLTVLYPATGDTRQYALRNAPLTRVRFSPGDSITHFEGWKMTVQEVDDVDGLLVYHGLNGQNEAVTLPETQLSNFIQFRLASDRLFAGQIDPLAWFSLRYHTLEHTSRQLQSSLWGLGGVRAQPIAHQLHIAREVADRIAPRVLLADEVGLGKTIEAGLVIHRQLLSGRASRVLILVPENLQHQWLVEMRRRFNLQVALFDEERFIESDASNPFEDTQLALVALEWLVDDEKAQDALFAAGWDLMVVDEAHHLVWHEDQVSPEYALVEQLAETIPGVLLLTATPEQLGQDSHFARLRLLDPNRFHDLAAFRAESENYRPVAEAVQELMDKGRLSPEAHKTIHGFLGNEGEALLAAVNDGDSEASARLVRELLDRHGTGRVLFRNTRAAVQGFPERKLHAYPLPCPDEYLELPLGEHAELYPEVSFQAQPDVSDDEQRWWKFDPRVEWLIDQLKMLKRTKVLVICAHAETAMDLEDALRVRSGIPATVFHEGMNILERDRAAAYFADEEFGAQVLICSEIGSEGRNFQFAHHLVLFDLPSHPDLLEQRIGRLDRIGQKHVIELHVPYLETSPQERLFQWYHEALNAFLNTCPTGNALQHQFGPRLLPLLENADDGEWQALIDAARGERERLEAELHTGRDRLLELNSGGAGEGDALVEAILEQDDQFALPIYMETLFDAFGIDSEDHSENALILKPSEKMLDASFPLGDDEGVTITYDRNQALSREDMQFITWEHPMVQGGMDLVLSGSMGNTAVALIKNKALKPGTVLLELLYVSEVVAPRSLQLGRYLPPAALRCLLDANGNDLSARVAFETLNDQLESVPKASANKFIQAQRDQLAPKINAGEAKVAPRHAERVAEAQRRLAADTDEELARLTALQAVNPTVRDSELVALRQQREQGLAMLEKAALRLEAIRVLVAG
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: Y2183_AZOSB
Sequence: MPSFDITSEVDEPSLRNSVDVANSKIAGRHDFKGTSANVELKEKLMTLYGDSDFQLDQMKAILLPEMTKKKVDVRCLEYGDVQKVSGNKVKQEVKVRVGVDQDLAKKIVKLLKDSKLKVQAAIQGDAVRVSGAKRDVLQEAIALVKKQITDFPLQFGNFRD
What are the official names of this protein?
UPF0234 protein azo2183.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RTCB_DICDI
Sequence: MTDSVVRGFEDELSFIEKIDSVRYRVKKGFVPNMNVDGMIYVNDSIKDYLYEELEQYSKRGVSGFLPAVKQIANVASLPGIVGHSLGMPDIHSGYGFSIGNVAAFDTEDPLSIVSPGGVGFDINCGVRLLRTNLTEKDIEPIKEQLCQSLFDHVPVGVGSKGVIPMNIKTLNQALEMGVDWSLGEGYAWVEDKEHCEEYGRMLNADPTKVSERAKKRGLPQLGTLGAGNHYLEVQVVDEIYDKAAANKMGIDRQGQICIMIHSGSRGLGHQVATDSLTLMEKAMARDHIHLNDKQLACSRINSTEGQDYLSGMAAAANFAWVNRQSMTFLTRQAFAKAFNSTPDDLDMHVIYDVSHNIAKFEEHNVNGRPKKLLVHRKGATRAFAPHHPLIPVDYQFTGQPVLIGGTMGTCSYVLTGTELGMNETFGSTCHGAGRSCSRNKSRNNLSYTDVLDSLQAKGISIRVASPKLVMEEAPESYKDVVQVIETCHKAGISKKSVKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: GLMM_METM5
Sequence: MKLFGTSGIRMKNLDPLIAYKVGYAISKNFKKAVIGRDTRTTGNLIESAITAGLLNGGCDVTTIGMVPTPVLGYSAKDYDLGIMITASHNPPEYNGIKLFNKNGTAFDPKQEKELENIINNDDFNEGTWDNIGCVIEDKTAVKNYSEYILQNLDIKTNFNVVVDCANAAGCVVSPNIFTEAGCKVISVNSHCDGRFVGRMPEPNEKNLKETVDIIKGLNSNCRNYIGIAHDGDADRMIAIDELGRVTDFDKLLAAFCKYIVQKTGADKIVTTVDASMAIDEYLNEFGAEVVRTKIGDVAVAEELEKTGAIFGGEPSGTWIHRDIHLTPDGILSGLRVLEMMEFYDKKLHEIIDEVPSYYNMREKILCPDNLKQQVMDYVSKEGEKIFEKKPETLDGVRFSFEKGWILIRPSGTESYVRVRVEAKEKDFAEKLMKTGISMVYTGISGN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ATSL_BOMMO
Sequence: MESSVATHWLSAFVILCSFITTQSLNNKIHEHMTIDELRNVFHVEHHSRVPEYHLVQLTHHLARRNIPTSHPANSNSADSGKTPHLKTEKVTKGGYKAPSLLNDEMFVEAKKRIEDVDIMGDPNSTVSVDFKVQSSEFGDSESLSDKEHSAESQEDGVHKIDLEAFGRQLKLVLKKQEGLIKKDGLKVWKALKNETQPHGVDYEEMITEDDEEFGDLYQDEENGAALLIRRHPKHGKLVVEGSIGHDLVIRPIPDTMTSPAQDDEMFMDPSSMADMVSIDTGLPIMKRKKEEQDRLQEALNGAQHVIIKRDPAEVDHMSDYAFMEPDHIGKRYRRKRSAEAHNRQKREAPYVIYPEILVIVDYDGYRLHGGDNVQIKRYFVSFWNGVDLRYKLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRQYANDACNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAEKCRWEDGFIMSDLRHTEKGFRWSPCSVQSFHHFLNGDTATCLYNSPHEDDSLPRVLPGRLLTLDAQCRKDRGTSACFKDERVCAQLFCFDAGSGYCVAYRPAAEGSPCGDGQYCINGQCITEHENIIPDYSQHTPSYVRPETSPFYANITSSRH
What is the function of this protein?
Involved in larval molting and metamorphosis.  May degrade extracellular matrix (ECM) and basement membrane (BM) during the development of organs to allow degeneration and remodeling of tissues.
What are the official names of this protein?
A disintegrin and metalloproteinase with thrombospondin motifs like, ADAMTS-like, BmADAMTS-like.
Protein: PYRI_CLOBL
Sequence: MLTINSIKNGIVIDHIQAGHGIKIFKYLGLEEADYRVALIMNAESSKLGKKDIIKIENIMEIDYKVLGFIDPTITIDVIENETIKEKIKLELPKTIENVIKCKNPRCITSIENYIPNEFYLVDEENGEYRCKYCDEIYSGGDINKL
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: HUPD_THIRO
Sequence: MRSDPEILVLGIGNLLWADEGFGVRAVEALQRHWVMSSNVQLLDGGTQGIYLVDRVRKADVLVVFDAVDYGLPPGTMKRVEDDEVPRFLGAKKMSLHQTGFQEVLALAAMLGDYPKHLLLIGVQPVELDDFGGSLRPQIKERITPAIEMALEYLAQFGVVARRREDSTVDSPHLPHPSLDLIAYESGRPGPEIACRIGDERVLTSLSARTVQPGNPHGDRQ
What is the function of this protein?
Not known.  Could be involved in the processing of hydrogenase.
What are the official names of this protein?
Hydrogenase expression/formation protein HupD.
What is the protein family that this protein belongs to?
Belongs to the peptidase A31 family.
Protein: RHO1_CANAL
Sequence: MVNGPAELRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGRKVELALWDTAGQEDYDRLRPLSYPDSNVILICFSVDSPDSLDNVLEKWISEVLHFCQGVPIILVGCKSDLRDDPHTIEALRQQQQQPVSTSEGQQVAQRIGAADYLECSAKTGRGVREVFEAATRASLRVKEKKEKKKKCVVL
What are the official names of this protein?
GTP-binding protein RHO1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: PARL_HUMAN
Sequence: MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
What is the function of this protein?
Required for the control of apoptosis during postnatal growth.  Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity).  Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088).  Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872).  Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (PubMed:32573439).
What are the official names of this protein?
Presenilins-associated rhomboid-like protein, mitochondrial, Mitochondrial intramembrane cleaving protease PARL.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [P-beta]: Nucleus. Note=Translocated into the nucleus by an unknown mechanism (PubMed:17116872).
Protein: SYG_NOCFA
Sequence: MEKSRVAPKSKVDTVANLAKRRGLVYPCGEIYGGTKSAWDYGPLGVELKENIKRQWWRSMVTSREDVVGLDSSVILPRQVWEASGHVATFTDPLVESLITHKRYRADHLLEAYEEKHGHPPANGLADIRDPETGEPGRWTEPRNFSGLLKTFLGPVDDEEGLHYLRPETAQGIFINYKNVETTARKKPPFGIAQIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWHQYWIDTRLAWYTDLGIDPENLRLYEHPKEKLSHYSTRTVDIEYRFRFQGSEWGELEGVANRTDYDLKTHSEHSGTELSYFDQANNERYIPYVIEPAAGLTRSLMAFLVDAYAEDEAPNAKGGVDVRTVLRLDRRLAPVKAAVLPLSRNADLTPKAKDLAAQLRKHWNVEFDDAGAIGRRYRRQDEIGTPFCITVDFDTLEDQAVTIRERDSMAQERIALDKVEGYLAQHLIGV
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_YERPG
Sequence: MPFTLGQRWISDTESELGLGTVVAIDVRMITLLFPATGENRLYARNDSPITRVMFNPSDTITHHEGWQLKVEEVTQENGLITYIGTRLDTEETGVAMREVLLDSKLTFSKPQDRLFAGQIDRMDRFALRFRARKYQSEQFRLPWSGLRGIRASLIPHQLHIAYEVGQRHAPRVLLADEVGLGKTIEAGMIIHQQLLAGRAERVLIVVPESLQHQWLVEMLRRFNLRFSLFDDSRYSEALLDSSNPFDTEQMVICSLDFVRRNKQRLEQLADASWDLLVVDEAHHMAWSEEAPSREYQVIEQLAEHIPGVLLLTATPEQLGQQSHFARLRLLDPDRFHDYEEFVNEQQKYRPIADAVTLLLGGERLTDDKLNLLGELIDEQDIEPLLKAANSQSEDSEAARQELVTMLMDRHGTSRVLFRNTRNGVKGFPHRVLHQIKLPLPTQYQTAIKVSGIMGAKKTLDARAKDMLYPEQIYQEFEGENATWWNFDPRVEWLLNYLVANRGEKVLVICAQAATALQLEQVLREREAIRAAVFHEGLSLIERDRAAAYFASEEDGAQVLLCSEIGSEGRNFQFACQLVMFDLPFNPDLLEQRIGRLDRIGQNREIQIMVPYLEDTAQAILVRWYHEGLDAFEHTCPTGRTIYDSSYQELISYLATPSEQEGLDEFIHTCRQQHEGLKLQLEQGRDRLLEMHSNGGEHGQELAQSIAEQDNDINLVSFALNLFDIVGINQEDRSDNLIVLTPSDHMLVPDFPGLPPDGCTVTFDREQALSREDAQFVSWEHPIIRNGLDLILSGDTGSCAVSLLKNKALPVGTLLAELVYVVEAQAPKHLQLTRFLPPTPVRMLMDRNGTNLAAQVEFESFNRQLNAVNRHTSSKLVNAVQQEVHTMLQQAEALVEAQAQALIETAKREADDKLSTELARLEALKAVNPNIRDDEIEALEHNRKMVLENLNQAGWRLDAIRLVVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: CCM1_SCHPO
Sequence: MLNKCSGSLTLLAVRRFCGPCRRLHYHKDNPNNINIAKNLLNNNIQARCSTNEASWKLAQKELDLKIREYEQKLKDVKLNDINKKSPLNIPDEVWTKFISEVNSYDKEKENHLSTGNHELRRTTPLKIGPLLLTRIGLLKSKNTASNNYSVDHIVSNLANDNTLLNRQVSTEEWNSHLRHLLNIPKCFLGVDIVEIVNFFNYLPQTVISKSSLEIWKAVEESGMKVMPDLLVLLMESTNASGDFRKTVQLYHLYQKSNAPPNGLVYQSYAIALSSLGKHKDLVALYSEQKSVSITPSKDFLNACIKAFSRTKEFTKAWEVFNFMKFTATSISPSAETYGLMIQICSSQYNPEKALDLYNEMKLRPIDPLTPTTFVINNLIHALATDVRFQTVAFSLLQDLSHYGLRPNHSTLYELIRLIAYSGKLDYMKDILDNFWVRQKLLPSILKVEQIFHFIFRALISAEVQTSSVTPDYTHFKEEVRKIIDSSKEPLIPFLKRSTLTENDLFLNAIYTFEYAKRKFPEALNSRLVTDFLNIFLERGSVQLFKEIYQLEFREMSTMEGSSMKVAKITLTYIYAIKLALLFNDFEFGYAAWQEYWHCKIHKLLPKEDASYEQKVVLLTLSLLSKNKHTSLARSLLLSHLDKGWTWNKHSLGFMRKMCSVMNDQATVYLIDSITNEIGINQRFTRK
What is the function of this protein?
RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts.  Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein 3, mitochondrial, Mitochondrial group I intron splicing factor dmr1.
What is the protein family that this protein belongs to?
Belongs to the CCM1 family.
Protein: EFTU_NITOC
Sequence: MSKSKFERKKPHINVGTIGHVDHGKTTLTAALTRILSEQYGGEFRAYDQIDNAPEERERGITIATSHVEYETEERHYAHVDCPGHADYVKNMITGAAQMDGAVLVVSAADGPMPQTREHILLARQVGVPFILVYLNKADMVDDPELLELVEMEVRELLDSYQFPGDDTPIVVGSALKALEGDTSEIGIPSILKLVEQMDAYIPEPQRAVDQPFLMPIEDVFSISGRGTVVTGRVERGIVKVGEEIEIVGMRETQKTICTGVEMFRKLLDEGRAGDNVGVLLRGTKREDVERGQVLAKPKSITPHTKFYAEVYVLSKDEGGRHTPFFTGYRPQFYFRTTDVTGAIDLPDGVEMVMPGDNIQMTVSLIAPIAMEEGLRFAVREGGRTVGAGVVSKVIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXLYS_BPP22
Sequence: MQIKTKGDLVRAALRKLGVASDATLTDVEPQSMQDAVDDLEAMMAEWYQDGKGIITGYVFSDDENPPAEGDDHGLRSSAVSAVFHNLACRIAPDYALEATAKIIATAKYGKELLYKQTAISRAKRAPYPSRMPTGSGNSFANLNEWHYFPGEQNADSTTPHDEGNG
What is the function of this protein?
Tail protein located at the vertex occupied by the portal ring.  12 copies of gp4 form a structural ring at the bottom of the portal ring.  Together with gp10 and gp26, gp4 is required for stabilization of the condensed DNA within the capsid; perhaps by plugging the hole through which the DNA enters.  Probably functions as a head completion protein.  Plays a role in ejection of the bacteriophage DNA into the host cell at the initiation of infection.  Functions as an exolysin that catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycans.
What are the official names of this protein?
Peptidoglycan hydrolase gp4, Gene product 4, Gp4, Internal virion protein gp4, Tail adapter protein gp4.
What are the subcellular locations of this protein?
Virion.
Protein: BAKOR_RAT
Sequence: MASPSGKGSWTPEAPGFGPRALAPDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSQLKNKQEEFQKEVLKAMEGKRLTDQLRWKIMSCKMRIEQLKQTICKGNEEMKKNSEGLLKNKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTSDLREHYDRLACLRRLHILELTSVIFPMDEVKTSGRDPADVSSETDSAMTSSMVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYNWVEEKKTTQGPDMEHNNPAYTISAALGYATQLVNIVSHILDINLPKKLCNSEFCGENLSKQRLTRAVRKLNANILYLCSSQHVNLDQLQPLHTLRNLMHLVSPHSEHLGRSGPFEVRADLEESMEFVDPGVAGESDVSGDERVSDEETDLGTDWENLPSPRFCDIPSQPVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
What is the function of this protein?
Required for both basal and inducible autophagy.  Determines the localization of the autophagy-specific PI3-kinase complex.  Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine.  Promotes BECN1 translocation from the trans-Golgi network to autophagosomes.  Enhances PIK3C3 activity in a BECN1-dependent manner.  Essential for the autophagy-dependent phosphorylation of BECN1.  Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK.  Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion.  Modulates the hepatic lipid metabolism (By similarity).
What are the official names of this protein?
Beclin 1-associated autophagy-related key regulator, Barkor, Autophagy-related protein 14-like protein, Atg14L.
What is the protein family that this protein belongs to?
Belongs to the ATG14 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions (By similarity). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (By similarity). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
Protein: MNMA_DEHM1
Sequence: MNDTSELIMVAMSGGVDSSVAAMLLLEQGYDVAGVSLQLKSNNEPYGNGYNLKLINRAREVAAALGIPHYVVDLSDIFSQRVIADFCQQYSQGRTPNPCIRCNYYVKIGALLEKIPDFNAGYLATGHYARVLSDENGTHLLKGADEKKDQSYFLYTLPPESLSRLIFPLGKRYKKDIIRLADKMKLPVSQKESQDVCFIPDGDYKSFLATRMGFTPGKILDKTGKILGEHQGLPLYTIGQRQGLGLASNEKLFVSDMNPEANTIMVASHDQLYTSRILLSNFIWRESRIPLDTPGMIVKVRYKAAPAEVKKISQTGDFYLLELASPVWAATPGQAAVIYLGDMVLGGGIIEHGGDVA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_PHEZH
Sequence: MAVVDLIDLPAIAPPNTPLVGLDLGEKTIGVAVSDATRMVASPLGLIRKTKFTDDAKALFKLMESRRASGIVIGLPVNMDGTEGTRCQSNRAFARNLLRLREDLPIAFWDERMSTMAVNRMLVGEADMTRARRADVVDKMAAAWILQGALDRLRNL
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALS2_PANTR
Sequence: MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSVAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLRNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
What is the function of this protein?
May act as a GTPase regulator.  Controls survival and growth of spinal motoneurons (By similarity).
What are the official names of this protein?
Alsin, Amyotrophic lateral sclerosis 2 protein homolog.
Protein: Y440_STAAM
Sequence: MRDSKRVVLYISIIVLSIFIIGCGKGNEIKEDAKEEQIKKSFAKTLDMYPIKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKSNRPGVLDNEGMVLNLDRNTRTAKGYYFVDTIYDNHENSYSKNYRVEMKNNKIILLDKVEDQKLKERIENFKFFGQYADFKSLKSYNHGDVSINSNVPSYDAKFKMSNKDENVKQLRSRYNIPTDKAPILKMHIDGDLKGSSVGYKKLEIDFSKEENSELSIVDSLNFQPAKNKDDE
What are the official names of this protein?
Uncharacterized lipoprotein SAV0440.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.