PharMolix/UniProtQA huggingface dataset:
Protein: ARHGJ_HUMAN
Sequence: MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRAPGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPRHTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVELSGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTSATSKLGEAPV
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 19, Ephexin-2.
Protein: RSRC1_MOUSE
Sequence: MGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRRPRSDSRSWSRDRQLRSHSYERRRRRRSSSSSSYGSRRKRSRSRSRGRGKPYRVQRSRSKSRTRRSRSRPRPRSHSRSSERSSHRRTRSRSRDRDRRKVRDKEKREKEKDKGKDKEVHSIKRGDSGNIKAGLEHLPPAEQAKARLQLVLEAAAKADEALKAKERSEEEAKRRKEEDQATLVEQVKRVKEIEAIESDSFVQQTFRSSKDVKKAVEPSEVQHVTAASGPASAAAEPPSTGKEIDPDSIPTAIKYQDDNSLAHPNLFIEKAEAEEKWFKRLIALRQERLMGSPVA
What is the function of this protein?
Plays a role in pre-mRNA splicing.  Involved in both constitutive and alternative pre-mRNA splicing.  May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity).
What are the official names of this protein?
Serine/Arginine-related protein 53, SRrp53, Arginine/serine-rich coiled-coil protein 1.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.
Protein: DHYSL_LEIDO
Sequence: MLASVPAPRPAKKDSAASRRKSASKSTGAAVKDGSSARVSASGAAESPKQSCAQVHGVDFQSLVHATQEETLRAVVSSLPTTGLQATQIGRARQLVQQILHHRSPEDRVFLAYTSNMISCGLRDTFTYLARERLVDCFISSAGGIEEDVIKCGGSTLLGQFGQDGRALRRRGINRIGNLLVPNDNYCWFEDFFTPVLESVQEAQRASRWKTHTAPSEIIEAMGAAIAKNHPDTCTSSLVYWCYRNGISVFSPAFTDGSMGDMIYFYNFSHKGLVVDPLEDVVRLRKLAAKERGRNLAIVLGGGLPKHHLLRNVPMDAVVMVTTGLEADGCVSSGVLADDVACGLLREETETVRVQGDATVVFPLMLIAETAATREGAAA
What are the official names of this protein?
Inactive deoxyhypusine synthase, Deoxyhypusine synthase-like protein, Deoxyhypusine synthase-like protein from chromosome 20, DHSL20.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: CYB_PERTA
Sequence: MASLRKSHPLLKIANHILVDLPAPSNISAWWNFGSLLGLCLATQILTGLFLAMHYTSDIATAFSSVMHICRDVNYGWLIRNMHANGASFFFICIYLHIGRGLYYGSYLYKETWNVGVALFLLTMMTAFVGYVLPWGQMSFWGATVITNLMSAVPYVGNDLVQWIWGGFSVDNATLTRFFAFHFLFPFVIAALTAIHLLFLHETGSNNPAGLNSDADKVTFHPYFSYKDLLGFATLMVTLTSLALFSPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLSSILILTAVPALHASKQRSTTFRPITQLLFWTLVAAVLVLTWIGGMPVEHPFIIIGQIASLLYFMLFLTLIPAAALAENKALEWN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GATC_MICLC
Sequence: MPEITRDQVEHLARLAHIRMTDEELDTMSGDLEKILEHVSAVQAAAGDDVTPTSHPIALENVFREDVPAGMLTQEEALDQAPDSEDGQFKVPAILDGE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: EI2BD_HUMAN
Sequence: MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQVGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
What is the function of this protein?
(Microbial infection) In case of infection by influenza A virus; required for viral replication in tracheal cells.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: TRPD_MYCGI
Sequence: MTTPPPRPAAPTTDPGDTPTWAMILGRLTTGQSLLPGQTAWAMDQIMTGVATPAQIAAFAVSMKMKRPTSAEVTELAEIMLKHALPVPTDTIGTHTVDIVGTGGDGANTVNLSTMASIVVAAAGVPVVKHGNRAASSLSGGADTLEALGLRIDLGPDDVARCVAEVGIGFAFAPQFHPSYRHAGAVRREIGVPTVFNLLGPLTNPAKPRAGLIGCAWGDLAEVMAGVFATRGSSALVVHGDDGLDELTTTTTSTIWRVQAGTVERLTFDPAAFGFARAHVSELTGGDAEANAASAREVLGGATGPVRDAVLLNAAGAMVAHAGLSSDAKWVPAWESGLARAKEAIDSGAAEQLLARWVRFTQEL
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: COX8A_ATEBE
Sequence: MYVVTPLLLRGLTGSARRLPVPRAQVHSMPPEQKLGVLELAIGFTSCMVTFLLPAGWIMSHLESYKKRG
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 8A, mitochondrial, Cytochrome c oxidase polypeptide VIII-liver, Cytochrome c oxidase subunit 8-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIII family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MTNA_PSEA7
Sequence: MRERLLAAERVKAIEWRDGTLRLLDQRLLPQEEVWLDHGSAAEVAKAIRDMVVRGAPAIGISAAYGIVLGARARLARGGDWRTALEEDFRLLADSRPTAVNLFWALNRMRERLERMKEGDRPLAVLEAEAISIHDSDREANLTMAQLGMELIRKQQSSPQNILTHCNTGALATGGFGTALGVIRAAHLEGLVNRIHADETRPWLQGSRLTAWELANEGIPVSLNVDSAAAHLMKTENITWVIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLESGEDIPIEERDGRELLEIGGRRVAAEVDAYNPVFDVTPADLIDAIVTERGVVERPDAERMAALMSRKRLH
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: RS8_LACLS
Sequence: MVMTDPIADFLTRIRNGNMRKFDVVEAPASKIKRQIAEILKAEGYVKDVEYVEDNKQGVIRVFLKYGKNGEKVITNLKRISKPGLRVYVKSDDVPKVLNGLGTAIISTSTGVVTDKVARQTNVGGEVIAYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RS6_CUPTR
Sequence: MRHYEIVFIVHPDQSEQVPAMIERYKQLVTSQNGNVHRVEDWGRRQMAYMIQKLAKAHYVCLNIECGKETLAELEHAFKFNDAVLRHLIVQTKKAETAPSPMMKEVQREEARKAAQTTTEGQAA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ASPA_PROMA
Sequence: MSGIQVLLVAGTHGNEINAPWLFEQWKQKDSLINTHNINIQTVIGNPVALEQGKRYVDRDLNRSFRKDLLLSSDLNAAEHFRALELVSEYGPNGNNPCQIAIDFHSTTSSMGSSLVVYGRRPADLAIVSLIQNHLGLPIYLHEGDNAQSGFLVESWPCGFVVEVGPVPQGLLHFQIINQTLLTLDSCLKEISNVINSKTVYPEQLIVHRHLKNIDFPRDSSGVPSSLVHKDIQGRDWYPIKNGHPLFESLSGDLTLLLEGGLEEEFVPVFINEAAYAEKNIAMSLTKKEMWDVQKDWINDLSKLLNP
What are the official names of this protein?
Probable aspartoacylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein: COX2_SHEEP
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLPSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UB12B_XENLA
Sequence: MEILMTVSRIASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKENLLTCLSDLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRIPNGNIDNENNNNTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD
What is the function of this protein?
Deubiquitinating enzyme.  Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 12-B, Deubiquitinating enzyme 12-B, Ubiquitin thioesterase 12-B, Ubiquitin-specific-processing protease 12-B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP12/USP46 subfamily.
Protein: YXEO_BACSU
Sequence: MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLLRCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNITEALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHAILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHIIEQGTPEELFDHPKNERTKRFIKQVGEPAELI
What is the function of this protein?
Probably part of the ABC transporter complex YxeMNO that could be involved in amino-acid import.  May transport S-methylcysteine.  Responsible for energy coupling to the transport system (Probable).
What are the official names of this protein?
Probable amino-acid import ATP-binding protein YxeO.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: E178_SSV1
Sequence: MDQRRVEDIAQIGAYSLPYDIVNIVYGAIVIYRASQEGKDPLAYASNKQGFKEAVKKLIKLGVIEKTTPYSLKKEYEEQVEKFDEIINYEDYERARYELYKLSEKADNLFTSSLVLYASVFLSLSELKPEILKIINEYIDQQTKVDYGKWIVIGIATASVLFAIASVLIHILAHVSIW
What is the function of this protein?
This protein is non-essential for virus function.
What are the official names of this protein?
Uncharacterized protein E-178.
Protein: NDUA8_NEUCR
Sequence: MASRIPQFNQQVLYDTTPLPDSIPKVKELGASSAPLMSAAYFIGARCRDYNDDFMQCKNENPGKGEFECLKEGRRVTRCARSVIADINKSCLEEFRKHWTCLEDNNQQLWQCRPAEWKLNKCVFENLGLKKEIPDQPPNVTPVHLRKQMIYAHWPIPRSAEPFVPPTQTGDNNKAPAAASSSS
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 20.8 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA8 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: RL10_STRGG
Sequence: MARPDKAAAVAELTDQFRSSNAAVLTEYRGLTVAQLKELRRSLGENAQYAVVKNTLTKIAANEAGIDTLDDLFSGPTAVAFVTGDPVESAKGLRDFAKDNPNLIIKGGVLDGKALSADEIKKLADLESREVLLSKLAGAFKGKQTQAAQVFQALPSKFVRTAEALRAKKEEQGGAGTPAPAEAAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NPNT_MOUSE
Sequence: MAVLLAAVLASSLYLQVAADFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPQCKHGECVGPNKCKCHPGFAGKTCNQDLNECGLKPRPCKHRCMNTFGSYKCYCLNGYMLLPDGSCSSALSCSMANCQYGCDVVKGQVRCQCPSPGLQLAPDGRTCVDIDECATGRVSCPRFRQCVNTFGSYICKCHTGFDLMYIGGKYQCHDIDECSLGQHQCSSYARCYNIHGSYKCQCRDGYEGDGLNCVYIPKVMIEPSGPIHMPERNGTISKGDGGHANRIPDAGSTRWPLKTPYIPPVITNRPTSKPTTRPTPNPTPQPTPPPPPPLPTEPRTTPLPPTPERPSTRPTTIAPATSTTTRVITVDNRIQTDPQKPRGDVFIPRQPTNDLFEIFEIERGVSADEEVKDDPGILIHSCNFDHGLCGWIREKDSDLHWETARDPAGGQYLTVSAAKAPGGKAARLVLRLGHLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGTHGAALWGRNGGHGWRQTQITLRGADVKSVIFKGEKRRGHTGEIGLDDVSLKRGRC
What is the function of this protein?
Functional ligand of integrin alpha-8/beta-1 in kidney development.  Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development.  May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
What are the official names of this protein?
Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain.
What is the protein family that this protein belongs to?
Belongs to the nephronectin family.
Protein: RL15_BRUC2
Sequence: MKLNDLRDKPGSVKARKRVGRGIGSGTGKTGGRGVKGQKSRSGVSINGFEGGQMPIYRRLPKRGFTNIFAKSFNVVSLGRIQAAIDAGKLDAKAVVNLDSLKAAGVIRRAKDGVRILSDGELKAKVAFEVAGASKAAVEKIEKAGGSIKLPEAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RAPA_PROMH
Sequence: MPFTLGQRWISDTESELGLGTVVAIDARMVTLLFPACGENRLYSRHDAPITRVMFNVGDTVTSHEGWKLAIDNVVEDNGLLIYHGVRLDTEEPAQLREVFLDNKLTFNKPQDRLFAGQIDRMDRFALRYRARKFMSEQFKQAQSGLRGIRASLIPHQLYIANEVGKRHNPRVLLADEVGLGKTIEAGMIIHQQIMDGRAERVLIIVPESLQHQWLVEMLRRFNLRFSLFDDSRYSESLLDSDNPFETEQMIICSLDFVRKNKQRFEHLVEATWDMLVVDEAHHLVWSEKAPSREYQVIETLAEAIPSVLLLTATPEQLGQESHFARLRLLDPNRFHDYNEFINEQQKYRPVADAVTILLSEDDLNNEQQNSISEMISEQDIEPLLKASNTQGEERTKSRQALIHMLMDRHGTGRLLFRNTRSGVKGFPNRLLHAIKMPLPTQYQTAIKVAEIMAAKKSLEVRAKEMLYPERIYQEFEGENATWWNFDPRVEWLLGFLTANRHEKVLVICAQAATALQLEQVLREREGIRAAVFHEGMSLLERDRAAAYFASEEEGAQVLLCSEIGSEGRNFQFANQLVMFDLPFNPDLLEQRIGRLDRIGQNRDIDISVPYLEGTAQSVLLRWYHEGLDAFEHTCPTGRTIYDNEYDALVNYLAQPNELGDFDKFIVSCRKQHDEMKLKLEQGRDRLLEMHSNGGEVGVELANKIAEQDNDPDLVNFALNLFDIVGINQEDRSDSLIVLTPSDHMLVPDFPGLPQDGCTITFDREHALSREDTQFISWEHPIIRNGLDLVLSGDTGSCAVSLLKNKALPVGTLLVELIYVVEAQAPKHLHLTRFLPATPVRLLLDLKGNNLASQVEFESFNRQLNAVNRHTSSKLVNAVQNEVHHVLKASESLMEAEAKTLIEQAKQEADNALTHELSRLEALRAVNPNIRDDEVEAIENERTHILNHLDEATWRLDAIRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: SESA_SINX2
Sequence: MTAEQAINEGAFSLAASFGFVPLEYRGYEAEVLASKETAYIGTALNGAMSPIYDVTGPDALEFLRSVCINSFRGFQVGQIRHAVLCNDKGQILTDGVVARIDEDTYRTYWLAPALEYRLINSGLDVKGEDQSSNEFFFQLAGPRSLEVLEAAAHEDLHDIAFGRHRMSTIAGIPVRILRLGMAGGLAYEVHGAAADTETAYRAIWEAGQPFGLVKQGLNAYLMQHTEAGFPNINLHYPLPWYEDPDMAAFFDTRPTQNFYNKYRFFYGSVGPDAEARFVTPYQIGLGKMVDFNHDFIGKEALQREAEADHWAAVTLVWNEDDVADVVASKYRGRDVEPYDKIDDRPFDIYHNLGQPGFAYHADWVLADGERIGTSTGRINSVYYRRMISLGFIDKRHAAEGTELTVLWGRPGTPQKEIRVTVGRYPYFDLEKNNAIDVASIPRPALDVSAGA
What is the function of this protein?
Converts sesamin into sesamin mono- and di-catechol.  Catalyzes a ring cleavage to transfer the methylene group to tetrahydrofolate (THF).  Also active with (+)-episesamin, (-)-asarinin, sesaminol, (+)-sesamolin and piperine.
What are the official names of this protein?
Sesamin methylene transferase, Sesamin-metabolizing enzyme, THF-dependent sesamin/sesamin-monocatechol methylenetransferase.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: SYP_HALOH
Sequence: MRMSNLYIPTLKEVPKEAEVVSHQLMLRAGLIRNLTAGVYSFLPLGYRVIKKIEGIIRKVMDESGAQEVLMPVIHTSDLWKESGRWEKFGPLMIKFEDRKGREYCLGPTHEEVITDLVRDEIRSYKDLPLNLYQIQTKVRDEIRPRFGLMRSREFIMKDAYSFDRDYEGLDKSYQVMYGAYTEVFNRCGLEVRAVEADTGAMGGKDSHEFMVLAESGEDDIAFCNRCDYAANVERAEARYVKSEKNEEIKPLEKVETPGKKKIDELVEFLKMPSEKMIKAVAYLADGEPVLALVRGDDELNEVKLINYLDVIELTPVVDEDFPQYYNSYAGYVGPIGLKNVRIIADRKVKDIVNGICGANEENYHFINVNPERDFSVEKYLDIRKVKEGDQCPHCEGTIEIKSGIEVGHIFKLGTKYSESMGATYLDENGKEQPIVMGSYGIGVTRLVAAAIEQNHDEHGIIWPKAIAPYQVIILPLGKGDEVNKRAEELYLELKDNNIEVLLDDRNERAGVKFNDADLIGIPLRLTIGSRSLDKGVIEARVRGTGQDYEISVEDAIKDIKKLLENVK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEP19_RAT
Sequence: MKYIAKKCGVRFQPPAMILIYENEAEGKSRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVSLKQLEKLFVFLRGSLQGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKRKDDPSFVYDVEVEFPQDEQLQSCSWDTASVDEF
What is the function of this protein?
Required for ciliation.  Recruits the RABL2B GTPase to the ciliary base to initiate ciliation.  After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia.  Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly.  Involved in microtubule (MT) anchoring at centrosomes.
What are the official names of this protein?
Centrosomal protein of 19 kDa, Cep19.
What is the protein family that this protein belongs to?
Belongs to the CEP19 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage.
Protein: TRUD_SHIF8
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGHGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: VE6_MMPV
Sequence: MPQPTRPYSFMELCREYTLEQLLKFLNVTLDTLMLPCHFCSSFMDLNNKASYLASQLKVIVKDCCFKGACIKCRRKLAFAERQKYQVCVGEADLVEAMVGSHVINLTVRCSECLALLTASEKLDAKCELQTFILVRHMWRTSCRACRTPAIEC
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.