PharMolix/UniProtQA huggingface dataset:
Protein: CP17A_FELCA
Sequence: MWELLVFLLFAVAYFLWPKAKCPGAKYPKSLPSLPLVGSLLFLPRSGHPHKNFFKLQKKYGPIYSFRLGTKTTVMVGDHQLAKEVLVKKGKEFSGRPHVVTLDILSDNQKGIAFADHGASWQMHRKLALATFALFKDGDQRLEKIICREISLLCDNLAMQDGQSIDLYLPLFLAVTNIICLICFNSSFKNGDPALKIIQNYNEGILKTLGKDNLVDIFPVLKIFPNKTLEKMKNYVKNRDELLREILEKHKENFSNDSITNMLDVLIQARMNSDNNGAASDQDSKLLSDKHILTTIGDIFGAGVETTTSVVRWTVAFLLHHPQLYKKLQEEIDQNIGFSRTPTMSDRNQLILLEATIREVLRIRPVAPTLIPHKAIMDSSIGEFAVDKGTNVIINLWALHHNEKEWYRPDQFMPERFLDPTRSQLISPSLSYLPFGAGPRSCLGESLARQEVFLFMAWLLQRFDLEVPDDGQLPHLEGNPTVVFLIAPFKVKVKVRQAWREAQAEGST
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: CYP10_CAEEL
Sequence: MSVTLHTTSGDIKIELYVDDAPKACENFLALCASDYYNGCIFHRNIKDFMVQTGDPTHSGKGGESIWGGPFEDEFVSALKHDSRGCVSMANNGPDSNRSQFFITYAKQAHLDMKYTLFGKVIDGFDTLEEIETIKVDNKYRPLVQQKIQNVTIHANPMAAD
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase 10, PPIase 10, Cyclophilin-10, Rotamase 10.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Protein: YHM7_SCHPO
Sequence: MMKPSNISISAVKLPQDLDDFKMLVQEYLQEFGMDLTFQNVDDELANPMRKYGPPHGIMLVARDEHGTALGCVAVHPFGGPGCCEMKRLYVRPESRGLKLGVLLVKEIIQYSEKLGYSSMVLDTLDTLLPAVRLYKSFGFKTTEPYYHNPIPNVVYMRLEMSK
What are the official names of this protein?
Uncharacterized N-acetyltransferase C1271.07c.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: APAH_XANCP
Sequence: MSVWAIGDLQGCYDITQQLLEKIRFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSVVVLGNHDLSLLAIGARSEEEQRKVNPDLQRIVLAEDRDVLLDWLRMQKLAHVDRELGWMMIHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGDQPGWSPGLSGYDRSRAIINLFTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGVHAIDTGAVWGGKLTALQLDTDELRVVQVPGREVTAPATAPRAPRRPRERQGRQRARGGRGGGNGNGNGGNAAAPAAAPGDAPQE
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: EFP_BACP2
Sequence: MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNLRTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSETQIKDELKYLLENMSVQIVMYGAETLGVELPNTVELEVVETEPGIKGDTTSGGSKPAKTETGLIVNVPFFVNQGDKLVINTSDGSYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_MYCUA
Sequence: MTERTLVLIKPDGVQRLLVGEIISRIERKGLAIAALELRNVTEELASQHYAEHEGKPFFGSLLEFITSAPVVAAIVEGPRAIAAFRQLAGGTDPVEKATPGTIRGDFGLETQFNLVHGSDSAESAQREIALWFPSA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPDF_JANSC
Sequence: MEKPAQRATAIIVAAGRGIRAGGGEPKQWRRIAGRSIVEWSVNRFAAHHAGFDVVLVIHPDDEWRLNGLDLPTTLRVVHGGDSRAASVKAGLAVCCDAGHVLIHDVARPCVSLAVIQSVLDATRAGGAAAPALPVTDALWRGDTHVSGTQNRDGLWRAQTPQGFDVSAIRAAHAAHDGTAADDVEVARLAGIDVAIVPGDEANLKITGPEDFARAEALLTGGDMDIRVGNGFDVHRFGPGDQVWLCGISVPHTRGLQGHSDADVGLHTLTDAIYGALAEGDIGTHFPPSDPQWKDAESHIFLTHAVELAANRGFSITNADLTLICEQPKIGPVASAMRARVADLLRIDVARVSVKATTSERLGFTGREEGIAALATITLVAR
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: PSBI_ADICA
Sequence: MLTLKLFVYAVVIFFVSLFVFGFLSNDPGRNPGRKD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MUT7_HUMAN
Sequence: MDPGDPAGDPAAGERHRMGRDPLLLLQALQTLWSTRERKQLREEAWRGFAALDDPLAGLLDMLESCRGQRGEGPSLAAWISHQLQCWLQAQPCPSLAQHSLRLKQLQARAVKVLTESPPSLAAPLASIFQLQDADRSCLLAHVHRLHHEGRFREAATLGATLKLQSELGVEKMSIPLLLQDKVALVERYVAGFPDLQRRLLVLMDSWCQPGFDIKDVARRYPEVTSLSLEKLSPKALSRQVLRLQERYGVAPALCPNAAIQQRLAALRHLCHKRFVEKSLSQENWTDHVQGLVGQSPWLQEQLSQLLVSHSDPVTAAQCAMELLLPEERLPAAVAVELRRFRLQGRATEADSRLEVKDMKDRYYQLPIPRENVHLLASWEDLTRHEGALLQCHQVVGVDVEWTPVFVAGGRPRPSLLQVAVEGHVFLLDVLALSQPPTGQGAQAFSRLVAQLLSDPSITKLGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQMRVASVPAPAVDRARELRGLSLLVQQVLGTALDKTQQLSNWDRRPLCEEQVIYAAADAYCLLEVHQALCREPARFHLSEDLAGSRRPRHRERPGARKPPGLQKASAPAAPRQVPVAVAVSEGAAPQIPARAFRVVCDNMLQGLARSLRCLGVDARMLGNGEDHRRAAEVARQEGRIILTSGQPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGDEATQSQAVQEPGPAPDAAPEGCTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESAPSPCEPSPAPSPASSPF
What is the function of this protein?
Possesses 3'-5' exoribonuclease activity.  Required for 3'-end trimming of AGO1-bound miRNAs (By similarity).
What are the official names of this protein?
Exonuclease mut-7 homolog, Exonuclease 3'-5' domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the mut-7 family.
Protein: NLT42_HORVU
Sequence: MARAAATQLVLVAMVAAMLIVATDAAISCGQVSSALSPCISYARGNGAKPPVACCSGVKRLAGAAQSTADKQAACKCIKSAAGGLNAGKAAGIPSMCGVSVPYAISASVDCSKIR
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein 4.2, LTP 4.2, Low-temperature-responsive protein 4.9.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: CYB_CORFR
Sequence: MGLNLRKNHPLLKIINNSLIDLPTPSNISAWWNFGSLLGLCLIMQIITGLLLAMHYTADTSLAFASVAHMCRDVQFGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLNKETWNIGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWLWGGFSVDNPTLTRFFAFHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDLLGFALMLIPLITLALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLIPLLHVSKQRSMTFRPLSQILFWTLVADLLILTWVGSQPVEHPFIIIGQLASFAYFAIILILFPVVSALENKILKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CAIE_SALSV
Sequence: MSYYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQDGCIMHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQGEARQLLVGSPARVLRQVTDQELHWKRLNTKEYQDLAIRCRTGLSETKPLTQVEENRPRLKGTTDVKPKSAQ
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: VP34_BPPRD
Sequence: MNDFVGPIVTVLTAIIGVAILAVLVSRNSNTAGVIKAGSGGFSSMLGTALSPVTGGTGFAMTNNYSGF
What are the official names of this protein?
Protein P34, Protein O, GpO.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Note=Part of the capsid inner membrane.
Protein: EFP_ANAPZ
Sequence: MAERGNDIRPGQVLDHNGALYLVVKTMHTQPGKGGAYIQAELKNLKTGAKYQERFRADGYVNRAIIEEVSFQYIFGDSSSLTLMNTENYEQISIPVELLGDKSVYLQENMILTLLFHKGQVISAKVPDYVVLEVVEAESVIKGQTASSSYKSAVLENGRRVSVPPFIKVGEKIVIYTPDDTYYERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I72A1
Sequence: MNPNQKIITIGSISLGLVVFNVLLHVVSIIVTVLILGRGGNNGICNETVVREYNETVRIEKVTQWHNTSVVEYMPYWNEGTYMNNTEAICDVKGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPTECRTFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVVHYGGVPTDVVNSWAGDILRTQESSCTCIQGDCYWVMTDGPANRQAQYRIYKANQGKIVGQTDVSFNGGHIEECSCYPNDGKVECVCRDNWTGTNRPVLVISPDLAYRVGYLCAGLPSDTPRGEDAQFTGSCTSPMGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRVRNGWTQTSKEQVRKQVVVDNLNWSGYSGSFTLPVELSGKYCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDIDKM
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: HTPX_MYCMM
Sequence: MTWHPHANRLKTFLLLVGMSAMIVFFGALFGRTALILAVLFAVGMNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVRELATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGILALLNERELRAVLGHELSHVYNRDILISCIAGALASVITALANMAMWAGMFGGNRDGQNPFALLLVSLLGPIAATVVRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQLAPLPPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEQMARG
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7S_LISMC
Sequence: MATKKKTFEEAIAELETIVEALENGSASLEDSLDMYQKGIELTKLCQDKLQSAEKRMAKVVTDAGEEIPFEADGE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CURC1_MOLLA
Sequence: MAAKFLLTILVTFAAVASLGMADNVLLSGQTLHADHSLQAGAYTLTIQNKCNLVKYQNGRQIWASNTDRRGSGCRLTLLSDGNLVIYDHNNNDVWGSACWGDNGKYALVLQKDGRFVIYGPVLWSLGPNGCRRVNGGITVAKDSTEPQHEDIKMVINN
What is the function of this protein?
Taste-modifying protein; sweet-tasting.  After curculin, water elicits a sweet taste, and sour substances induce a stronger sense of sweetness.
What are the official names of this protein?
Curculin-1, Neoculin basic subunit, NBS.
Protein: CPCE_PSETP
Sequence: MNEETGIPDDNLLTIEQAIANLQSEDLGLRVYAAWWLGRFRVNVPEAIDLLIAALADEADRTEAGGYPLRRNAARALGKLGDRRAVPALITSLECDDFYVREAVAQSLEMLGDNSCVPYLIELIKNPNPEASADTEPEHPYDAFLEALGTLGAVKAIPHILPFLDHPIPKVQYAAARAMYQLSEPMVADQYGDRLVAALANDDLQLRRTVLSDLGAIGYLSAAEAIGNTMAENSLKLISLKGLLEKQIVLATPPDLTDGAIRVMALMDDLL
What is the function of this protein?
Required for the chromophorylation of the cpcA1 gene product.
What are the official names of this protein?
Phycocyanobilin lyase subunit alpha, Phycocyanin-1 operon protein CpcE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: FTSH2_PETMO
Sequence: MNNNPNRRGSLIGPLFIYFILAMLIFMSISQLNTSNITEISYTDLVNLINQDTIISLQIDTSGLIQAKAKNGQLFQVYAPTLLMDQAYVRALANDGIKVEYIQNTGASWWVTMLIYMLPLIILMFFWFWMFRRSGTGEGIPGANYRRNPARRYDSKRNKITFNDVAGIDEVKEELEDIVNFLKDPKNFSALGAKMPKGVLLSGPPGTGKTLVARAVAGEADVPFYFMSGSDFVELFVGVGAARVRDLFKEAKENSPAIIFIDELDAVGRQRGTGLGGGHDEREQTLNALLVEMDGFDPREGIVVMAATNRPDILDKALLRPGRFDKKIFLDVPDLRAREEIIKIHLRGKRIADDIDVKSLAQSTPGFVGADLENMVNEAALLAARDNRDHITNDDFQEAIERVIVGPARKSRKITPKEKKVITYHELGHAVLGYLLPYADPVHKITIVPRGQAALGYTMQLPSEDRFLITEPEIKDKIVGMLGGRAAEEIVFNEITTGAGNDLKRATELVREMVAQLGMSEKIGPIAWGEEEGEIFLGREITRMKNFSQETAKEIDSEIKNFILSSYEKAKNLLSENRKRLDLLAIYLYNKENISGKEFKKMMEMDIEELNDYVLKDKDVKETNLFVSYA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: PSN_CAEEL
Sequence: MPSTRRQQEGGGADAETHTVYGTNLITNRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQKCLLY
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1).  Provides the major presenilin function compared to hop-1 and spe-4.  Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis.  Required for mesodermal patterning of muscle function.  Promotes basement membrane gap formation during tissue remodeling (PubMed:27661254).
What are the official names of this protein?
Presenilin sel-12, Suppressor/enhancer of lin-12 protein 12.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RIHA_SALA4
Sequence: MALPIIIDCDPGHDDAIALVLALASPELEVKAITSSAGNQTPEKTLRNVLRMLTLLKRPDIPVAGGAVKPLMRELIIADNVHGESGLDGPALPEPSFAPQSGTAVELMAKTLRESSQPVTIVSTGPQTNVALLLNSHPELHAKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHKAQIHAADIERFRAIGNPISTIVAELLDFFMEYHKDEKWGFVGAPLHDPCTIAWLLKPEIFTTVERWVGVETQGKYTQGMTVVDYYFLTGNKPNATVMVDVDRQGFVDLLAERLQYYA
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: Y1795_LISIN
Sequence: MYLPKEKEIIQIKSYKHNGKLHRTWKKTVVLKSTENIIIGGNDHTLVVEADGRKWVTREPSICYFHSDYWFNVISMIREDGIYHYCNLGTPFAVDEQALKYIDYDLDIKVFPDGRFHLLDEGEYEQHRRQMKYPDSIDRILKTNVDVLSHWILDKKGPFSPDYIDIWYEKYKEYR
What are the official names of this protein?
UPF0374 protein lin1795.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: RS14_ECOK1
Sequence: MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNASDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ATPB_STUS1
Sequence: MSSGRIVQIIGAVIDVEFPRDLVPNVYDALKVQGAETTLEVQQQLGDGIVRTIAMGSTEGLKRGLDVVNTGTGISVPVGKQTLGRIMDVLGNPIDEAGPIGEEERWTIHRAAPSYSEQAGGNELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAMEHSGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKNGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRDIASLGIYPAVDPLDSTSRQLDPLVIGQEHYDTARGVQYVLQRYKELKDIIAILGMDELSEQDKQLVSRARKIQRFLSQPFFVAEVFTGSPGKYVPLKETIRGFSGILNGDYDHLPEQAFYMVGSIDEAIEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RRB1_SCHPO
Sequence: MSKRAAEETVEFNSKNGPGQRGTVADNVDTEMGEFEDAYEDEIESEEEYIEADGEKDNGMDEEEQNDAQPSKIPWLPGGKINADEKLVADPSVYEMLHNIQVKWPFLSFDILQDSLGEERRAWPHQMYLVGGSQALDSNDNELTVMKLSQLYKTQHDENDDASDNSDVEEDPILEHKSISTKGACNRVRSARRPANSSKESLLASFHETGKVHIWDIAPHLRSLDSPGVMVSRKENSPLYTVNRHKTEGYALDWSPFEYSLLSGDNANEIFLTKYSNGGWQTDSSPFLSHTAAVEDLQWSPSEKNVFSSCSCDGTFRIWDVRNKQKTSALTVNAHPGVDVNVLSWNTRVPNLLATGADNGVWSVWDLRSLKSSSSVATPVASFKWHRAPIYSIEWHPNEDSVIGVVGADNQISLWDLSVELDEEEQDSRAAEGLQDVPPQLMFIHMGQQEIKEMHWHRQIPGTIVSTAMTGINVFKTITF
What is the function of this protein?
Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly.  May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA (By similarity).
What are the official names of this protein?
Ribosome assembly protein rrb1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: ATP4A_XENLA
Sequence: MGKKEQYDMYSVEMEREGDGAMDVKVMKKNKASKKKEKLESMKKEMDINDHEITVEELEQKYTTSVSKGLKSAFAAEVILRDGPNELKPPKGTPEYIKFARQLAGGLQCLMWVAAVICLIAFGIEESQGDLTSADNLYLAITLIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVVRDGDKFQINANQLVVGDLVEIKGGDRVPADIRIITSQGCKVDNSSLTGESEPQTRSPEYTHESPLETRNIAFFSTMCLEGTATGIIINTGDRTIIGRIATLASGVGNEKTPIAIEIEHFVDIIAGLAIFFGATFFVVAMVIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQSFDQTSDTWRALSKVVSLCNRAFFKSGQDGIPVPKRIVIGDASETALVKFSEITVGNVMEYRERFKKVTEVPFNSTNKFQLSIHELQDPLDLRYLMVMKGAPERILERCSTIMIKGQELPLDEQWKEAFQTAYMDLGGLGERVLGFCHLYLNEKEYSRGFNFDTEEMNFPTSGLCFAGLISMIDPPRATVPDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRIPVEQVNKRDARACVINGGQLKEMSSEELVEALKLHPEMVFARTSPQQKLIIVESCQKLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELAPYLIYITASVPLPLGCITILFIELCTDIFPSVSLAYERAESDIMHLKPRNPRRDRLVNEALAVYSYFQIGIIQSFAGFVDYFTVMAQEGWFPAYVLGLRSHWENQHLQDLQDSYGQEWTFSQRLYQQYTCYTVFFISYEICQISDVLIRKTRRLSVFQQGFFRNKVLVIAIVFQLCLGNFLCYCPGMPNVFNFMPIRFQWWLVPLPFGILIFVYDEIRKLGVRRHPGSWFDKEMYY
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.  Responsible for acid production in the stomach.
What are the official names of this protein?
Potassium-transporting ATPase alpha chain 1, Gastric H(+)/K(+) ATPase subunit alpha, Proton pump.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.