PharMolix/UniProtQA huggingface dataset:
Protein: METE_STRMU
Sequence: MTKVSSLGYPRLGENREWKKLIEAYWAGKVSKNDLFAGAKELRLDFLKKQLNAGLDLIPVGDFSLYDHILDLSVQFNIIPKRFAKEPIDIDLYFAIARGNKENVASSMKKWFNTNYHYIVPEWSKQRPKLNNNRLLDLYLEAREVVGDKAKPVITGPITYVALSTGVEDFTAAVKSLLPLYKQVFTELVKAGASYIQVDEPIFVTDEGKDYLQAAKAVYAYFAKEVPDAKFIFQTYFEGLIDSQVLSQLPVDAFGLDFVYGLEENLEAIKTGAFKGKEIFAGVIDGRNIWSSDFVKTSALLETIEEQSAALTIQPSCSLLHVPVTTKNETDLDPVLRNGLAFADEKLTEVKRLAEHLDGREDPAYDLHIAHFDALQAADFRNVKLEDLSRVATKRPSDFAKRRDIQQEKLHLPLLPTTTIGSFPQSREIRRTRLAWKRGDISDAEYKQFIQAEIERWIRIQEDLDLDVLVHGEFERVDMVEFFGQKLAGFTTTKFGWVQSYGSRAVKPPIIYGDVQHLEPITVEETVYAQSLTDRPVKGMLTGPITITNWSFERTDIPRDQLFNQIGLAIKDEIKLLENAGIAIIQVDEAALREGLPLRKSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDEIIDAIRALDADVISIETSRSHGDIIESFETAVYPLGIGLGVYDIHSPRVPTKEEVVANIERPLRQLSPTQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQKLGN
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: SYC_STAAB
Sequence: MITLYNTLTRQKEVFKPIEPGKVKMYVCGPTVYNYIHIGNARPAINYDVVRRYFEYQGYNVEYVSNFTDVDDKLIKRSQELNQTVPEIAEKYIAAFHEDVGALNVRKATSNPRVMDHMDDIIQFIKDLVDQGYAYESGGDVYFRTRKFEGYGKLSHQSIDDLKVGARIDAGEHKEDALDFTLWKKAKPGEISWDSPFGEGRPGWHIECSVMAFHELGPTIDIHAGGSDLQFPHHENEIAQSEAHNHAPFSNYWMHNGFINIDNEKMSKSLGNFILVHDIIKEVDPDVLRFFMISVHYRSPINYNLELVESARSGLERIRNSYQLIEERAQIATNIENQQTYIDQIDAILNRFETVMNDDFNTANAITAWYDLAKLANKYVLENTTSTEVIDKFKAVYQIFSDVLGVPLKSKNADELLDEDVEKLIEERNEARKNKDFARADEIRDMLKSQNIILEDTPQGVRFKRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_SULDN
Sequence: MNDKVFTKAIKKQFEFDEEVAAVFDDMLQRSVPFYKESQKISEFFAQKALQNGGIAYDLGCSTATLLINISRKLQNKATLIGLDNSEAMLQRARKKCEAFKADIELENADILEYDYREANLFISNYTLQFVRPLIREELVKKIASSLKKDGLFIFSEKVISHHSKLHKDLIECYYDFKKEQGYSEYEIVQKREALENVLIPYSEEENIKMAKNCGFSHCEVVFRWANFATFIAIK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: PPPA_ECOLI
Sequence: MLFDVFQQYPTAMPVLATVGGLIIGSFLNVVIWRYPIMLRQQMAEFHGEMSSAQSKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVWPESGWGLAVMILSAWLIAASVIDLDHQWLPDVFTQGVLWTGLIAAWAQQSPLTLQDAVTGVLVGFITFYSLRWIAGIVLRKEALGMGDVLLFAALGGWVGALSLPNVALIASCCGLIYAVITKRGSTTLPFGPCLSLGGIATLYLQALF
What is the function of this protein?
A pre-pilin peptidase involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.
What are the official names of this protein?
Prepilin peptidase PppA.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1099_HAEIN
Sequence: MYLMRKIVFVSCVILGLAACSSQPEQIGGGVYDMKTVQEYNARVISGNTVTQTQKDKITQQIDTSLKLNQSDNKVKTRTRRVLPVLPVTPSVGYHYNYHYFR
What are the official names of this protein?
Uncharacterized protein HI_1099.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RECQ_PASMU
Sequence: MFSSSLLSKDNKSAVDFHEIPLKQTALDVLHAVFGYQSFRKGQEEVIDATLMGKDSLVIMATGNGKSLCYQIPALCFEGLTLVISPLISLMKDQVDQLLANGIEADYLNSSQTFTEQQQVQNKLMSGTLKLLYVSPEKVMTTSFFHLISHCKVSFVAIDEAHCISQWGHDFRPEYTQLGGLKSCFPHAPIMALTATADHATRQDILRHLNLQSPHVYIGSFDRPNIRYTLVEKFKPMEQLCRFVLGQKGKSGIIYCNSRSKVERIAESLRNKGVSAQAYHAGLETSQREQVQRAFQRDNVQVVVATIAFGMGINKSNVRFVVHFDLPRSIESYYQETGRAGRDDLPAEAVLFYEPADYAWLHKILLEKPESPQRQIEALKLQAIGEFAESQTCRRLVLLNYFGEHQQKPCQNCDICLDPPKQYDGLIDAQKVMSTIYRIGQRFGVHYVIAVLRGLSNQKIKDNQHEQLSVYGIGKDKSKEHWQSVIRQLIHLGFIKQVFDHFNATLQLTENAKPILRGEQPLSLAMPRISSLTSVVAPQRYAIAQYDKDLFARLRFLRKQIADKENIPAYIVFNDATLQEMAQYQPTTKAEMLAINGVGATKFERFAQPFMQIIQQHKKVLTQHEPPLSLES
What is the function of this protein?
DNA helicase.
What are the official names of this protein?
ATP-dependent DNA helicase RecQ.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
Protein: Y15_BPT3
Sequence: MWLILFAIVATLGLMVADDNIWPDC
What are the official names of this protein?
Uncharacterized gene 1.5 protein.
Protein: SEPF_CYAP4
Sequence: MSSIFGKLREFVGFGEPTGYDYDYDEMEGDDYQGLYPAEPAQSLPTRSEEPHPRPSEPEMRSPVNTSAVTSTAMNPPMNQSMNNVVGMPGSGKWWGAVAEVIVMEPRSFEEMPQVIQALRERKSVVLNLTMMEPDQAQRAVDFVAGATYTIDGHQERIGESIFLFTPSCVQVSTQAGGQSHTLRDIPQAQIHTRPPAPAWTAEPLSRIAQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: SMT1_ORYSJ
Sequence: MSRSGAMDLASGLGGKITKDEVKSAVDEYEKYHGYYGGKEEARKSNYTDMVNKYYDLATSFYEYGWGESFHFAHRWNGESLRESIKRHEHFLALQLGVKPGMKVLDVGCGIGGPLREIAKFSLASVTGLNNNEYQITRGKELNRVAGVSGTCDFVKADFMKMPFSDNTFDAVYAIEATCHAPDPVGCYKEIYRVLKPGQCFAVYEWCITDHYEPNNATHKRIKDEIELGNGLPDIRSTQQCLQAAKDAGFEVIWDKDLAEDSPVPWYLPLDPSRFSLSSFRLTTVGRAITRTMVKALEYVGLAPQGSERVSNFLEKAAEGLVEGGKKEIFTPMYFFLVRKPISE
What is the function of this protein?
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.
What are the official names of this protein?
Cycloartenol-C-24-methyltransferase 1, 24-sterol C-methyltransferase 1, Sterol C-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: XNI_SALA4
Sequence: MAAHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIIHSQPTHAVAVFDDDARSSGWRHQRLPDYKAGRPPMPDDLHNEMPALRAAFEQRGVRCWASDGNEADDLAATLALKVTEAGHQATIVSTDKGYCQLLSPGLRIRDYFQKRWLDAPFIEKEFGVLPRQLPDYWGLAGISSSKVPGVAGIGPKSATQLLIQFQNLEGIYAHLDEVPEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLAR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: RL25_YERPY
Sequence: MTTINVEVRNDQGKGASRRLRAANKFPAIVYGGSEAAISIALDHDTTKNLELKPGFYDSVLTLVIDGKETKVKVQAVQRHAFKPKLTHIDFVRV
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: UN13B_DROME
Sequence: MDEEQMWKGFFFKLQELKMNPPTEHEHQLQDGDDGFFEKFGSLLRQKSQIDEGVLKSSLAPLEENGSGGEEDSDESPDGTLQLSQDSECTSIDTFATESTLASSSDKDISTSVLDSAPVMNVTDLYEEILFEIFNNIGCENNEECTNSLVEFVQDAFKIPNATHEEIYEAARLKEPPNVRLNVEIIKAENLMSKDSNGLSDPFVTLYLESNGSHRYNSSVKPATLNPIWEEHFSLPITENARDEVLIVEVWDFDAAETVKEKVNKILDVKGVKGLSKLMKEIAVTASSGKHDNELIGRAAITLKSIPVSGLTVWYNLEKGSKGRSRGSLLVNLALSAEKNKSVAVQEHKNLLKLLLMYELETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAYSTIHETHKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRLLPSCFAVLRKLRSKNTSDKNIIRALNEVLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDETCNIDTAIEDAINTGTREWLEHIVEGSRQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYHKIQLNYSAVLYLFYDSKLAEICKSIIIEVCNNIKRLDVPDDQFEYLPNLENVNMGTTLFEVYLILKRYVQLGESLCSEPLELSNFYPWFERGVTHWLDISIIKALSRIQKAIDLDQLKAVDETVKYSSSAVDTLSIFYQIKIFWQQLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVENIFIADDNNKNFILSEEWCIAINNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCASTIKTVIENALDTERNQIVELIEIVARKMAPPIRRYLAEGAEVLAKDSNSMDQLMMYLESSLATLYDTLNEINFQRILDGIWSELSIIMYDLIQSNLDKRRPPAFFQNLNNTLQTMMDCFKMGNLQTSDIKILSSIQSRLRLYSLETSDLIHQYYLERLENQKSQESSPYGQLTITAQLTDTGLLLNILNARNLLPMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSDHQRSEKNSLIVFSIKDKDLFGMSSQYIAESYISFADLEATPPGEQIMMNLSRPEYTDSESLRALEYRLGDKQAKDFLKKLKNRSFS
What is the function of this protein?
Essential for tracheal development in embryos.  Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis).  Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs).  Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells.  May also function in the maturation and exocytosis of the SLs.
What are the official names of this protein?
Protein unc-13 homolog 4B, Protein Staccato.
What is the protein family that this protein belongs to?
Belongs to the unc-13 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, filopodium. Late endosome. Lysosome. Note=Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.
Protein: ARLY_DECAR
Sequence: MTSNANQYTWAGRFSEPVSDLVKRYTASVDFDQRMWRQDIRGSLAHARMLAKQGIIAAADLADIERGMAIVTEEIESGKFEWSLDLEDVHLNIEKRLTALVGDAGKRLHTGRSRNDQVATDIRLYLRDSIDDILVLIKAFRSALVDLAEKEAATPMPGFTHLQVAQPVTFGHHMLAYFEMFGRDAERYADCRKRVARLPLGAAALAGTTYPIDRAYVAEQLGFEGVCENSLDAVSDRDFAIEFTAACALLMMHISRLSEELVMWMSPRIGFIQIADRFCTGSSIMPQKKNPDVPELARGKTGRVYGQLMSLLTLMKSQPLAYNKDNQEDKEPLFDAVDTVTDTLRIFADMAGGITVRADNMKAALTQGFATATDLADYLVKKGLPFRDAHEAVGHAVKAAEQKGVDLPQLTLDELKAFCPQVESDVFAVLTVEGSLASRNHIGGTAPEQVRAAVARARQRLS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_XANC8
Sequence: MSEIPGDLKFLKSHEWARVEGNGRVTVGISDHAQGLLGDLVYVELPAVGDTVQAGNGAAVVESVKAASDVYSPVTGTVVEVNASLSDKPETINEDAYGEGWIFVVEIDDKEQLNELLAPDDYAELLEDDAH
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: PRSA_GEOTN
Sequence: MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEKVLSKKYKVTDEEIDREIERIKEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKVTDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGEDFAKLAKEYSQDPGSASNGGDLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFEVKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ILV6_YEAST
Sequence: MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAVSSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLHHHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDISETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEIVDISQLPPG
What is the function of this protein?
Regulatory subunit of mitochondrial acetolactate synthase, which catalyzes the first of a series of common steps in the biosynthesis of the branched-chain amino acids.  Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP.
What are the official names of this protein?
Acetolactate synthase small subunit, mitochondrial, Acetohydroxy-acid synthase small subunit, AHAS, ALS.
What is the protein family that this protein belongs to?
Belongs to the acetolactate synthase small subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BPT_VARPS
Sequence: MTHLKDLPLHTLQFYATAPYPCSYLPDRQARSQVATPSHLIHNDAYSDLVLSGFRRSGMFTYRPYCDGCRACIPLRVLVNSFQPSRSQRRAVKQHQNLLARVLKLCFVPEHYKLYLRYQTGRHAGGGMDHDSIDQYTQFLLQSRVNSRLVEFREALPDGTAGALKMVSILDVLNDGISAVYTFYEPDSSAGYGTYSVMWQIEQARKLGLPHVYLGYWIEGSAKMNYKARFAPHELLIDGRWQAPSDFTR
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTT1_USTMD
Sequence: MPPSGRKVSPSVSVVAGATAGAVEGVATFPIEYLKTVSQFAPRDVHGNQQRLSPIEVVRSTLQKEGPKGLFRGCTAMVVGNAGKAGVRFFAFENFRSMLKNKSTGKLSNSSNYLAGMGAGTLEAIFAVTPSETIKTKLIDDSKRAKPRYEQGLVRGTASIVRQEGLAGIYQGVVPVVMRQGSASAIRLGTYSALRDWLPKAHGSGSSLINWLATFSIGAASGVVAVYGTMPFDVLKTRMQAIDAARYRSTWHCLTNTLKTEGAAALWRGSVSRSMRLIVSGGVIFSVYEQVVWLLAGPES
What is the function of this protein?
Mitochondrial tricarboxylate transporter; part of the gene cluster that mediates the biosynthesis of itaconic acid and 2-hydroxyparaconate (PubMed:26639528, PubMed:27750034).  Cis-aconitate is secreted by the mitochondrial tricarboxylate transporter MTT1 (PubMed:26639528).  In the cytosol cis-aconitate is converted into trans-aconitate via isomerization by the aconitate-delta-isomerase ADI1 (PubMed:26639528).  Decarboxylation of trans-aconitate by the trans-aconitate decarboxylase TAD1 then leads then to the production of itaconic acid (PubMed:26639528).  The cytochrome P450 monooxygenase CYP3 further converts itaconate to 2-hydroxyparaconate via oxidation of the double bond, leading to a transient epoxide, which can subsequently be lactonized to produce 2-hydroxyparaconate (PubMed:27750034).  Secretion of itaconate and possibly 2-hydroxyparaconate into the medium is mediated by the major facilitator ITP1 (PubMed:26639528, PubMed:27750034).  The glyoxalase domain-containing protein RDO1 is not involved in the biosynthesis of itaconate and 2-hydroxyparaconate, however, it might play a role in the further conversion of 2-hydroxyparaconate to itatartarate (PubMed:27750034).
What are the official names of this protein?
Mitochondrial tricarboxylate transporter 1, Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein MTT1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: TRMB_XYLF2
Sequence: MMNLLSSDGVQVLPRPFTLNERRREVRSFVLRQGHFTPAQKRAFDHYWPRFGVDFIGQLRDLDVLFGRSAPKVLEVGFGNGAALRFAAQHEPRYDYIGIEVYAPGVGRLLNGLAEDGSRHVRLYHYDAVEVLNKEIVDGALDEIRIYFPDPWHKKRHHKRRLIQPLFATLLVRKLRVGGCLHMATDWADYAEQMWDVLDATPGLVNRAGLRGQVPCPDWRVQTRFERRGQNLGHRVWNLLYDRV
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: IL4_CERAT
Sequence: MGLTSQLLPPLFFLLACAGNFAHGHNCHIALREIIETLNSLTEQKTLCTKLTITDILAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGASAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEASQSTLEDFLERLKTIMREKYSKCSS
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_PSEE4
Sequence: MSKEPDRLFAQPLEQVPDFVFNEDVVQVFPDMIKRSVPGYPTIVENLGVLAARFAQPHSALYDLGASLGAVSQSLRRHVRSDGCRVIAVDNSAAMVERCRQYLTAQDSMFQELLPVQVLEADILTLPFEPASVVAMNFTLQFIAPEQRLALLGRIRQALLPGGALILSEKLRFADDQEQQLLNELHLDFKRANGYSELEIAQKRSAIENVMKPDTLETHKERLHAAGFSKVVPWFQCLNFASLIALP
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: TRM5_AEDAE
Sequence: MLFRRFLNLTTKTPHLQTFRARHYFRNMSCPELIPPPTVRGMTVLDKGAFDKRISAPRLIVPRQLNFQQICSSVKKLLLKMECFKPVVSGEYKITLHPSAVKTWEDLKEIGLEDKGLTEENLVWEQMKLGYDNWRYDEILKAVLPEDKEALSAFSKVGHIVHLNLKEHLLPYKNLIGTVIKDKVVGCRAVVNKLVTIDNTYRNFQMELLCGEEDYQVSLKENGCIFEFDFSKVYWNSRLSTEHGRVVEMLKKGDVLLDVYAGVGPFSIPAAKKGYSVLANDLNPDSYKALVHNCAKNKVQGRITCFNKNGIDFIKEEIKQFIISKNQDDTFTGTIHITMNLPALAVEHLENYVGLLKDEQIELKHFPLVHVYCFAKGVEDNKLLARGLVEKNMGIPLGNNLKEIAFVRNVAPNKDMMRVSFYLTRQILCHNDIQLKRPTSETSHQDAKRKCNVLRKIATMGKRNIKNRNQQKQTAKKVKNVFAVNQSKKGNVKKAKEVTSKLKKINVQDKREKADKKFQDLHAHIVAKKPEKKPLPAKPASKKNKNQANTKQVEAGLDKMQM
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: SIG22_CRISI
Sequence: IIGHLIKTALGFLGL
What is the function of this protein?
Has antibacterial activity against a wide spectrum of Gram-positive bacteria including B. cereus, E. faecalis, L. lactis, L. innocua, M. luteus, S. aureus, S. epidermidis and S. uberis.  Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli.
What are the official names of this protein?
Signiferin-2.2.
What are the subcellular locations of this protein?
Secreted.
Protein: GSA_ACIC1
Sequence: MTSPGTDAVSAACFERARARIPGGVNSPVRAFRAVGGTPRFIQSGAGPYLVDVDGNRYVDLVCSWGPLILGHAHPAVVAAVKQAAERGTSFGAPTEAEIEMAEEIARRVPAVEMIRLVNSGTEATMSALRLARAYTNRPLVVKFAGCYHGHVDALLSAAGSGVATLGLPGTPGVTPGQAAETIVLPYNDIDAVRTAFERYGGEIACVIVEAAAANMGVVPPEPGFNRALADIAHENGALLVLDEVLTGFRVSSAGWWGRDPVAADLFTFGKVIGGGLPIGAFGGRRDIMQLLAPAGTVYQAGTLSGNPVAVAAGLATLRESTPDIYARLDHVAAVLARALRDEFGRIGLPHQVQQAGNLFSVFFTTEPVRNYAQATGQEAWRYPPFFHALLDRGVHPPPSVYEAWFVSAAHDDAAVNQILDALPAAVRAAADARPPG
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATOH8_MOUSE
Sequence: MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPELGATVSTTAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAPLAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE
What is the function of this protein?
Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity).  Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity).  Modulates endothelial cell differentiation through NOS3 (By similarity).  May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035).  May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370).  During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595).  During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058).  Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity).  Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248).
What are the official names of this protein?
Transcription factor Atoh8, Helix-loop-helix protein mATH-6, mATH6, Okadin, Protein atonal homolog 8.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm.
Protein: PDXH_BRUME
Sequence: MEPVKMTNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDETGFVFYTNYESKKGQEILSAEKAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGSRIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPYWSGFRIRPVSIEFWHDRPFRLHDRVLFTRPTPEGDWNKDRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.