PharMolix/UniProtQA huggingface dataset:
Protein: SYVM_DICDI
Sequence: MNKLLFLSKKSSTSNLYRFYSRAPINESSIKSSFDPKVVEEFKYKYWQDSGLFKPKSNNGGEKFSMVLPPPNVTGSLHIGHSLTTTIQDSLIRYNRMMGKEVLWVPGLDHSGIATQVAVEKELQVKQGKTRFDLGREKFLEQVFQWTDQYSSNINNQLKITGSSLDWSRSVFTLDEQRNDAVQTAFIRMFEMGLIYRSTRLVNWCPYLQSVISDIEVDHKVIEKPTMLKLKSRKKSVEVGAIHNIAYMMEDPMLAPLIVSTTRPETIFGDTGLAIHPLDERYKDYHGKFAIHPFNHERIPIVLDDILVNREMGTGVVKITPAHDFNDYQCGQRHSLPIVNILNSNGTLNENSTAEFEGVDRLDARSMVIEKLEQMGLYREKLAHPQTLSICSRSGDLLEPVLKPQWYVKCKDMADKSIEFVESGEIKIIPESFRADWSRWLTNIQDWCISRQLWWGNPIPAYRVIMIDKVTNEDLDIHLTETERLKQEKWVVGKNEKEARENVFKTYGIANAGEYRLEKDQDVLDTWFSSGLFPISSMGWPTATKNSDNDNDFSRFLPLDVMETGSDILFFWVARMVMMCSTLNNGEVPFKTILLHPMIRDSQGRKMSKSLGNVIDPLHVINGISLQDLKENLSKSNLSQQEKVTATKGLEKEFPQGIPQCGTDSLRFSLAQYPINGKDINLDISKIIGNRLFCNKLWNASKFVFNYLVNLNNLSINLYYNNNNNEKDQQQPFNYLESTTLIDKWILLKLSKLVEIVNESYKSNNLSIAAQSLYSFFQYDFCDIYIECIKADLSKPILSKQNEHSSLVLASVLDSYLRMLHPFMPFITEDLWQRLPKSKQQLEIANSIEIDDSLSIMISDYPNPSYKYHQLFKNQEIEIEKQVNLFLDTLKLIRSQKVSLGINEKTKLIIKLQIIGDDQILIKSSFNQLKDSFEKLLNSNLIIDENNNNDNNNNNDNNDLTNISINKFTISKELQISIEFDKEINNQLNQKLINPNQSNDKKILKLENFIKQLQDEIDNPDFKQRVPEKVQNIKIEKLNQYKIELKEIYKK
What are the official names of this protein?
Probable valine--tRNA ligase, mitochondrial, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1492_HAEIN
Sequence: MKLLKALAVLSLATISSHSFAVDGFQNVKFGASKTEVRNAYQKCQWQKDEYDLFCPNFTLGAIKDTGAYFYFIDDKFERIAINIPNVNIDGIGQALSEKYTLSSQPTQRELANPKPNNVYDFGFDKDTILIRYTYDNDMTEEIFLIYTTPDFNNKLQTKDAQSVKDQL
What are the official names of this protein?
Uncharacterized protein HI_1492.
Protein: CYB_MEGWO
Sequence: MTNIRKSHPLFKIINDSLIDLPAPSSISSWWNFGSLLGICLGIQILTGLFLAMHYTSDTATAFQSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGLYYGSYTFMETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFLLPFIIAALVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDVLGALAMALVLLTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLALMPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFSLILVLMPLISIVENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DDL_BURM9
Sequence: MSGIDPKRFGKVAVLLGGDSAEREVSLNSGRLVLQGLRDAGIDAHPFDPAQRPLAALKDEGFVRAFNALHGGYGENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQTGIPTPPFETVMRGDDYAARAQDIVAKLGVPLFVKPASEGSSVAVEKVKSADALPAALEEAAKHDKIVIVEKSIEGGGEYTACIAADLDLPLIRIVPAGEFYDYHAKYIANDTQYLIPCGLDAAKEAEFKRIARRAFDVLGCTDWGRADFMLDAAGNPYFLEVNTAPGMTDHSLPPKAARAVGIGYSELVVKVLSLTLD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y8712_DICDI
Sequence: MKFNSISPNKQHHTGFTTSNNENLNQQLNQVLILLQTLQSQAKKIASFQNQTYEWNLKHHQNLKNVLKSFNRLNSIIDSKGSNNELNEKDNNEFENGVTFHQKIINTYDPLDPFSEELENLIMQIDRGLFHQLRDDSLEIIYPFILKWLKENNSLVLSLVLIWESSTKFHYLLNKKKFKEINKKILDCIVDYENKGIISTLINQNEFPFSDDEYNNLKKFLNDYS
What are the official names of this protein?
Putative uncharacterized protein DDB_G0268712.
Protein: PP2A2_PARTE
Sequence: MASLNKLSSNEIGNIDRQIAKLRQGQILTEQEVKSLCIKAKEILQDEPNIIQVRAPLTICGDIHGQFHDLIELFQIGGNLPDTNYLFLGDYVDRGSQSVETFSLMLSLKVRYKDRIVLLRGNHENREINKIYGFYDECFRKYGNEIVWKQFTEVFGYLPLSAIVEQQIFCAHGGLSPAMESVDQIKQLNRVQDIPHEGLMCDLLWSDPEETKNGWGISPRGAGWTWGCDITEKFLHSNKLKQIARAHQLVMEGIQKVHNQKTITIFSAPNYCYRCGNQACIVEVDEQLKMNQTQFEPAPRENEPHTTRRVPDYFL
What are the official names of this protein?
Serine/threonine-protein phosphatase PP2A catalytic subunit 2, PPN 2.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2A subfamily.
Protein: ZORO_ECO57
Sequence: MDTLTQKLTVLIAVLELLVALLRLIDLLK
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (PubMed:20156992, PubMed:24203704, PubMed:27903909, PubMed:31277504).  Expression in the absence of its cognate antitoxin (small sRNA orzO) leads to cell stasis and a decrease in colony-forming units (PubMed:24203704, PubMed:27903909).  Repression of ZorO toxicity requires base pairing between zorO mRNA and sRNA OrzO, as well as RNase III (rnc), suggesting the mRNA is degraded.  Base pairing occurs between 18 bases in the 5' UTR of zorO mRNA and the 5' end of OrzO sRNA.  sRNA OrzP, which differs only in 4 of these 18 bases, does not repress ZorO toxicity (PubMed:24203704).  Integration of the protein into the inner membrane damages membrane integrity and affects membrane potential.  It leads to increased levels of hydroxyl radicals (PubMed:31277504).
What are the official names of this protein?
Small toxic protein ZorO.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DDB2_ORYSJ
Sequence: MGPTTRARFVHNRRRRRRRGPYAAPDDDDEEEDQQEASSSSSSSDEGEEDAEEEGSGEVDDDDGEAAEPSGKEEEVSPVAAAARSGRKASITISLKKVCKVCKSTGHEAGFKGAVYIDCPRKPCFLCKMPGGHTTLTCPHRVAMEHGVIPASRRNTNTSLDYVFQSQVKGKIPMVKPQFLIPNQLECGNIKFHQRRVTCLEFHPTKNNVLLSGDKKGLLGVWDYVKLHEKITYDSVHSCILNSMKFDTTNDGLLYTASSDGTISSTDLDTGIGSSLLNLNPNGWNGPSTWRMIYGMDFNSDKGLLLVADSFGFLHLLDRRLKARIGDPILIHKKGSKVTSLHCNPAQPEVLLSSGNDHYARIWDTRKLEPNSAFVSLAHGRVVNSGYFSPQSGNKILTTCQDNRIRVWDYIFGNLESPSREIVHSHDFNRHLTPFKAEWDPKDHTETVAVIGRYISENYNGIALHPIDFIDTSTGKLLAEVMDPDITTISPVNKLHPRDDILASGSSRSIFIWKPKTESDATEERNREKAKEFVYGSGSRKKSNGKHENSSDDDSDGSCDGKKKKKAKKTRFTHTIKGKGKSKV
What is the function of this protein?
Required for DNA repair.  Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex).  The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable).  May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity).
What are the official names of this protein?
DNA damage-binding protein 2, UV-damaged DNA-binding protein 2, OsUV-DDB2, WD40 repeat-containing protein 2, OsWD40-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DDB2/WDR76 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM1_SHESW
Sequence: MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIEWLEEYHGLDHKDVAPCLYNYHGQTAVKHLMRVASGLDSLILGEPQILGQVKQAFAKAKEAGTVALTIDRLFQNTFSVAKKVRTETEIGAAAVSVAFAAVSMAKHIFSSLSTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKADIVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNMASRKEAAEQAELITEEQSYLFMDWVRSLESVDSIREYRNQSMAIKDELVERALNKLAQGGDTEQVLIELANRLTNKLIHAPTQALTAASRQGDLNTLGQLRTALGLDKN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: CLPX_BREBN
Sequence: MFKFNDDKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVQEELGTEEEIDMKEIPKPVEIRKILDDYVIGQDMAKKSLSVAVYNHYKRINSGAKIEDVELQKSNIMLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTSNILFICGGAFDGVEQIIKRRLGKKVIGFGADFGDGVKGDLKAGEYLKYILPEDLLKFGLIPEFVGRLPVLATLEPLDEETLVRILTEPKNSLVKQYQKLLSLDGVELEFDNGALLQIAKEAIKRNTGARGLRAIIEQIMLDMMYELPSREDVNKCVITEETVRDKVKPQLLTKEGQELHEETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: CGR1_DEBHA
Sequence: MSASSQMEYKDIPKRYIDPSAPKDVGEGSRVNGKDWKIKKDAFRVKTLGVKKLSTWEHREQKKLEQQQYKTRLQDLKQEKEDAKNQRISDLKRRREIKAEKERYEKMALKMHAKKVDRMRKREKRNKMLKER
What is the function of this protein?
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
What are the official names of this protein?
rRNA-processing protein CGR1.
What is the protein family that this protein belongs to?
Belongs to the CGR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TATB_MARN8
Sequence: MFDIGFLELLICGVIALLVLGPERLPTAARAAGRWIGGARRMVSQFTSELDRQLKAEELREELRKAGDVGLDDVEKTVRGALDEAKKYEHMILPDDQTRKPRPAPATRRVTPPSPEAGEQPEPPHEPVRDEAAASDQPSDSSPTSPSDKYS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YA016_YEAST
Sequence: MLYFYHINILIKERKYILIYSYLNRENYQLITEESKKNDIPSIVSTGYFFAFSFPITNVLE
What are the official names of this protein?
Putative uncharacterized protein YAL016C-B.
Protein: RSMA_PROMA
Sequence: MPFSGHVPRKRFGQHWLRDDSILEKILLAADLQEEDRILEIGPGRGALTEKLLESNVKLVHGVELDAELIVGLKQRFAGQSRFTLQEGDALSVSLLPHDGIAANKVVANIPYNITGPLLERLIGRLGRSSEVKYQRLVLLVQKEVAKRILALPGQSSFSAMSVRLQLLAKCQSVCEVHPSSFSPQPKVYSEVIILDPLEKDERLDFLVERRVASIVQIAFLSRRKKLRNTLTKICPLDELEPLAYRQGINLNQRPQELAPMIWVQLARELERWDRSKKK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_DESVH
Sequence: MSDYKKTLQLPETKFPMKANLTQREPEMLRKWEKDDAYGAMVRASGQQGTYVLHDGPPYANGNIHMGHALNKILKDIIVKSRNLQGFKAEYVPGWDCHGLPIELKVEHELGEKKRTMPAHAVRKRCRQYAEKYLDIQRKEFKRLGVFGAWDKPYVTMHPSYEAATARELGNFAAKGGLVRSKKPIYWCCSCQTALAEAEVEYHDHTSPSVHVRFPLRDPRVAEVLPGVDPAHAYIVIWTTTPWTLPDNMAVAVHPDFDYVVVRHGGDFHIVAEGLLEACLKAFKWDEHEVVARIGGRALEGLKATHPFYDRPSPIVLADYVTLESGTGCVHTAPGHGREDYETGLRYGLDIYSPLTDEGRYLDCVEFFAGMTIFEANPKVIEKLREVGNLLAEGRITHSYPHCWRCKKPVIFRATTQWFIAMERNDLRQKALDAIRDDVRWIPSWGQERIHNMIEFRPDWCISRQRMWGVPIVALLCEDCGEAWNDADWMRDIAERFAKHATGCDYWYETDLSDIVPAGLRCPKCGGDHWKKETDILDVWFDSGTSFAAVVEQREECGFPADLYLEGSDQHRGWFHSSLLASIGTRGVPPYRSVLTHGYVVDGDGRKMSKSVGNVVAPQEIIDKHGAEVLRLWVASVDYREDIRISEEILNRLVDAYRRIRNTCRYLLGNISDLTPETMVPFEAMDPLDRFALDLASRAHERIQDAYTEYEFHKVFHTLHNLCVTDLSAFYLDILKDRLYSSAADSHARRSAQTALYRILMLMVRDMAPVLSFTAEEVFGYVPAALRPDVISVFALPATDAPAFTLDTTSRAAWEKLLAVRSETTKAIEPLRKSGEVGHSLDTHVTLFADPSLKATLEGLGSDLRAMFIVSRLEVMDLADAPADAWTSEELPELKVTVRKAEGEKCERCWIISADLGTDAAHPTLCPRCTAVLTGTGA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINE_CALS4
Sequence: MDLFKAFGGKSNSKDIAKERLQLLLVHDRIDTSPRFLEMIKEDILNVISNYVDIDEKGLRVEITKERKSDDTFISALHANIPIKKMKQVIR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: OR1N2_HUMAN
Sequence: MEGFYLRRSHELQGMGKPGRVNQTTVSDFLLLGLSEWPEEQPLLFGIFLGMYLVTMVGNLLIILAISSDPHLHTPMYFFLANLSLTDACFTSASIPKMLANIHTQSQIISYSGCLAQLYFLLMFGGLDNCLLAVMAYDRYVAICQPLHYSTSMSPQLCALMLGVCWVLTNCPALMHTLLLTRVAFCAQKAIPHFYCDPSALLKLACSDTHVNELMIITMGLLFLTVPLLLIVFSYVRIFWAVFVISSPGGRWKAFSTCGSHLTVVLLFYGSLMGVYLLPPSTYSTERESRAAVLYMVIIPTLNPFIYSLRNRDMKEALGKLFVSGKTFFL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1N2, Olfactory receptor OR9-23.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACBP4_ORYSJ
Sequence: MGGDWQELAQAAVIGLLFAFLVAKLISTVIAFKEDNLRITRSTPTSPSAADTPAAPAPPPASLDGGHGDTSDGSGSDSDSDWEGVESTELDEEFSAASAFVAASAASGTSVPEQAQLQLYGLYKIATEGPCTAPQPSALKLKARAKWNAWHKLGAMPTEEAMQKYITVVDELFPNWSMGSSTKRKDEDTTVSASSSKGPMGPVFSSLMYEEEDQGNDSELGDIHVSAREGAIDDIAKHLAAGVEVNMRDSEGRTPLHWAVDRGHLNSVEILVNANADVNAQDNEGQTALHYAVLCEREDIAELLVKHHADVQIKDEDGNTVRELCPSSWSFMNLAN
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters with high affinity.  Can interact in vitro with palmitoyl-CoA, linoleoyl-CoA and linolenoyl-CoA (PubMed:21128943).  Binds phosphatidic acid (PA) and phosphatidylcholine (PC) in vitro.  May play a role in the biosynthesis of phospholipids (PubMed:24738983).
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 4, Acyl-CoA binding protein 4, OsACBP4.
What is the protein family that this protein belongs to?
Belongs to the ACBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: COP2_CONPU
Sequence: MKLLAPVLWAMAALGVTWLVAVDSKESCTKHSNGCSTPLRLPCQEYFRPACDIHDNCYHCGTIFGISRKECDDAFLKDMNTLCKKLGSNSATCPARGKREVTSHRATSIAHSRLWKTALDQKSFLNRKARQVFFLLPTTCQGWAKNYHLAVKLAGANSYSVTTDLETCQGLEHCLPNH
What is the function of this protein?
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Conodipine-P2, Cdpi-P2, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2, PLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group IX subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ILEUC_MOUSE
Sequence: MGQLSSANNLFALELFHTLNESNPTGNTIFSPVSISSALAMVYLGARGSTAAQLSKTLHFDSAEDIHSQFQSLTAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASIQKTYSADLALVDFQHASEDARKEINQWVKGQTEEKIQELFAVGVVDSMTKLVLVNATYFKGMWQKKFMARDTTDAPFRLSKKVTKTVKMMYLKNNLPFGYIPDLKCKVLEMPYQGGELSMVILLPEDIEDETTGLEEIEKQLTLEKLQECENLQNIDVCVKLPKFKMEESYILNSNLGQLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSYVEVNEEGTETDAAMPGTVVGCCLMPMEFTVDHPFLFFIRHNPTAHVLFLGRVCSP
What is the function of this protein?
Regulates the activity of the neutrophil proteases.  Forms only a stable complex with CTSG/Cathepsin G (By similarity).  During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
What are the official names of this protein?
Leukocyte elastase inhibitor C, Serine protease inhibitor EIC, Serpin B1c.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_HYDCU
Sequence: MGIEGVLKEGVVTTSADKLINWARTGSLWPMTFGLACCAVEMMHAGASRYDLDRFGIIFRPSPRQSDVMIVAGTLVNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGIIQLQNKIKRTNTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y2561_CLOBH
Sequence: MDNNVDTITLTDEEGKETEFEVITKLDIEDKEYVVVVPKNEEVDEAIALRIDNNDNGEEVLVPVEEDEEFNMVAEAYELLFSEE
What are the official names of this protein?
UPF0473 protein CBO2561/CLC_2432.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: VPS39_HUMAN
Sequence: MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085).  Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963).  Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).
What are the official names of this protein?
Vam6/Vps39-like protein, TRAP1-like protein, hVam6p.
What is the protein family that this protein belongs to?
Belongs to the VAM6/VPS39 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. SUBCELLULAR LOCATION: Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein.
Protein: SYL_LEPCP
Sequence: MNEKYDPAAIESAAHAQWVAADAYRVDENARDSQGQLKPKFYACSMLPYPSGKLHMGHVRNYTINDMLTRQLRMKGMNVLMPMGWDAFGLPAENAALKNSVPPEKWTRENIATMKGQMLAMGLAIDWSREVATCDPTYYKWNQWLFLKMLEAGIAERRTQVVNWDPVDQTVLANEQVIDGRGWRSGALVEKREIPGYYLNIVKYADELLGAVANPEDPNYLSGWPERVRLMQENWIGKSEGVRFAFPHQIAGADGELIQGGKLYVFTTRADTIMGVTFCAVAPEHPLAAHAAATNPALAAFIAECAHGGTTEAELATQEKKGLPTGLFVTHPLTGAQVEVWVGNYVLMSYGDGAVMGVPAHDERDFAFAKKYGISIRQVVQAEGQTFSLDGWADWYGDKQRAVCVNSGLLDGLPYKEAVSKVAELVGAQGLGEKKTTWRLRDWGISRQRYWGTPIPIIHCDDCGSVPVPEKDLPVVLPIDCVPDGSGNPLKKRTDFLNVACPCCGKPAQRETDTMDTFVDSSWYFMRYCDARNSEQMVAGGTDYWMPMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKVNEPFTKLLTQGMVLNHIYSRRTDKGGIEYFWPHEVENVFDAGGKVTGAKLKSDGSAVDYGGIGTMSKSKNNGVDPQDLINQYGADTARLFVMFASPPEQTLEWNDAGVEGAHRFLKRVWGFGVKQAELLKGATEVGAELSGDAKALRREVHLVLRQVSYDYERMQYNTVVSGSMKLLNALEAYKHDGSAGSAAVLREGYSVLLRGLYPACPHITHHLWSELGYAAKLGDLLDAPWPEVVEAALVQDEIELVLQVNGKTRGSIKVPAAADKAAIEAAAAASAEVAKFADGKPIRKLIVVPGRLVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_LEPBI
Sequence: MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPKVQKSYESMGFGGGSPLVEETAKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKPNQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYVPHFGLDPNFHSISAKFIYEFFTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADELSKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHIETLEEIGEQFKDLTWEMGGKSFVRIPALGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRFKD
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_STRPB
Sequence: MTDNSKIRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVKRDENGTVHMLRGADNGKDQTYFLSQLSQEQLQKTLFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKQFLSQYLPAQKGRMMTIDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNQPWFVVGKDLSQNILYVGQGFYHEALMSNSLDASVIHFTREMPEEFTFECTAKFRYRQPDSHVTVHVRGDKAEVVFAEPQRAITPGQAVVFYDGKECLGGGMIDMAYKNGQPCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.