PharMolix/UniProtQA huggingface dataset:
Protein: UGPE_RHIME
Sequence: MIEKRPISNLIGHLMLIIGIIIVVFPIYYTFVASSMSSVEIIRPPMPLVPGTRLAENYSEALSGGVERVVGVSLERLLFNTFVVAIAIAVGKIVISFLSAFAIVFFRFPLRMAFFWMIFITLMLPVEVRILPTYKVIVDLGLIDTYAGLTLPLMASATATFLFRQFFLTIPGELVEAARIDNAGPFRFMRDILLPLSKTNIAALFVILFIYGWTQYLWPLLVTNDSRMNTIIIGLRKMVDFTDASTPWNYVMVTAILAIIPPVAVVVLMQRWFVKGLVETEK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLPG_SALHS
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRGELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSRB_YERPA
Sequence: MAKELNPTENIEKLSDIQRYVTQERGTEAPFTGKLLHNKRDGVYQCLCCHQPLFISESKFDSGCGWPSFYQPIDADSIRYIDDYSHNMHRIEIRCGNCDAHLGHVFPDGPQPTGERYCINSASLNFVDDQNGEQTAG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: ZAPD_SHISS
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: FAU1_HYPBU
Sequence: MATPARRIPRVRVRGIYATALTKLVIDMGFQVVQPSRIIADRFSLPMLTLPADVTIKDSDNNPSELLIVGYEWAVNIILEKLRDTLPYSFYWRSSLPLHSTVKARVIGLRDNRCIARVGDVEAELLVDRSECIEDREVVGGVVRPGVKPRETPRIVPGARVIGDYAILIESSEPRVTISEHVRSPEKRALLAAIATSFTEQGYAVHWRSSSQHAEREELEKHLRQLREALAEARKRAEEGPPGVYSEGEAVVLVHLSSADKQKLDEIRDSVVATIPYHHTVKSLQPSLSKVIDYAEKVKALGVDSEKLVRALLELVAEDLASRRRIRILHVKPSGEYIELGKAEIKSVYVEDKSLVIVLERTVKSRGVYDGLGVEKEPGDRIVTEVRTDEWIVKHTYYAPDGTVKGTYININTPPEIAEDAIVYLDLEIDIVKKPGKKPKIVDAEELDKYHEQGIVTTKLKEKALEIARKLAG
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Binds to RNA in loop regions with AU-rich sequences.
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: O16C_CONVC
Sequence: MKLTCMVIVAVLFLTANTFVTADDSGNGLENLFSKAHHEIKNPEASNLNKRCIPFLHPCTFFFPDCCNSICAQFICL
What are the official names of this protein?
Conotoxin Vc6c, Vc6.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PPS_THEON
Sequence: MVKIPKSHPRYWSLYYREKIIEGMEKGMTAKAGLIAHGRGEAFDYLIGERTIEPAERAMRAAVAKLLLAENPVVSVNGNVAALVPKETIELARALNAKLEINLFYRTEDRVKAIAEELRKYDPEIELLGINPTKRIPGLEHERGKVDENGIWKADVVVVPLEDGDRTEALVRMGKFVITIDLNPLSRSARMADITIVDNIVRAYPRMTELAREMKDYSRGELIRIIEEYDNGKTLNDVLLHIRDRLTKLAEGGIWRKKQLD
What is the function of this protein?
Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
What are the official names of this protein?
4-phosphopantoate--beta-alanine ligase, Phosphopantothenate synthetase, PPS.
What is the protein family that this protein belongs to?
Belongs to the archaeal phosphopantothenate synthetase family.
Protein: COXX_BEII9
Sequence: MTFISQAPSVSISSAGPSDYFALLKPRVMSLVIFTALAGMLIAPDPVHPIVGFASLLAIAVGAGASGALNMWYDADIDAVMKRTAKRPIPLGRVMPNEALAFGLTLSFLSVFTLGIVANWLAAGFLAFTIFFYVVIYTMWLKRSTPQNIVIGGAAGAFPPMVGYAAATGHFSLSSFILFAIIFIWTPPHFWALALGRSEDYRQAGIPMMPNVKGAARTRLEILLYTLLLAPLGVAPWLLGFASFVYGMLSIALGAAMLFFAARVYIVQEGPSADRHAKALFGFSILYLFLLFAEIVVERLVPIVVAMGAWLTSGMFPGFFH
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASSY_GRABC
Sequence: MTRDIQTMAVKDVKKVVLAYSGGLDTSVILRWLQTTYNCEVVTFTADLGQGEELEPARRKAEMFGVKEIFVDDLRETFVKDFVFPMFRANAVYEGQYLLGTSIARPLIAQRQIEIAELTGADAVAHGATGKGNDQVRFELSYYALKPDVKVIAPWREWDLTSRTKLLEFAEANQIPIAKDKRGEAPFSVDANLLHSSSEGKLLEDPAEEPDEIVYQRTISPEAAPDKATIITIDFEHGDPVAIDGIRLSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLVAHRGIESITLDREAAHLKDSLMPRYAELIYNGFWFSPERRMLQAAIDESQKSVTGRVRLKLYKGNTIVIGRESPNSLYSLKHVTFEDDQGAYDQVDAQGFIKLQSLRLRLAAIAGRRGGSL
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLBH_TRICO
Sequence: MRFLLLAAFVAYAYAKSDEEIRKDALSALDVVPLGSTPEKLENGREFYKYFFTNHQDLRKYFKGAETFTADDIAKSDRFKKLGNQLLLSVHLAADTYDNEMIFRAFVRDTIDRHVDRGLDPKLWKEFWSIYQKFLESKGKTLSADQKAAFDAIGTRFNDEAQKQLAHHGLPHT
What is the function of this protein?
May be a globin and may play a role in oxygen transport.
What are the official names of this protein?
Globin-like host-protective antigen.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: Y680_CHLPN
Sequence: MLPLIIFVLLCGFYTSWNIGANDVANAVGPSVGSGVLTLRQAVVIAAIFEFFGALLLGDRVAGTIESSIVSVTNPMIASGDYMYGMTAALLATGVWLQLASFFGWPVSTTHSIVGAVIGFGLVLGKGTIIYWNSVGIILISWILSPFMGGCVAYLIFSFIRRHIFYKNDPVLAMVRVAPFLAALVIMTLGTVMISGGVILKVSSTPWAVSGVLVCGLLSYIITFYYVHTKHCSYISDTPKKGSLTYRLKERGGNYGRKYLVVERIFAYLQIIVACFMAFAHGSNDVANAIAPVAGVLRQAYPASYTSYTLIRLMAFGGIGLVIGLAIWGWRVIETVGCKITELTPSRGFSVGMGSALTIALASILGLPISTTHVVVGAVLGIGLARGIRAINLNIIKDIVLSWFITLPAGALLSILFFFALRALFH
What is the function of this protein?
Potential transporter for phosphate.
What are the official names of this protein?
Putative phosphate permease CPn_0680/CP_0067/CPj0680/CpB0707.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FETP_SACD2
Sequence: MSRTVNCRKFKQELEGLDFPPMPGAKGQDIFENVSKKAWQEWLSHQTMLINEKHLNMMDLTDRTYLNQQMDKFLSGEEYDQAEGYVAPEK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: Y9F0_ENCCU
Sequence: MDDPSGFEERFVHRFYDENSREFSATRRRHWGMTRRFLDNYYTRESIVLDAGCGNGRSFLVPCMVGMDYCLGLLNDARAAGGQGLVRGDVLELPFVDCSFDLVLSVAVIHHLSTRCRRERAMKEMRRVLKDGGKMLLYVWGSSAKSKRKFSRAAGGSEQDYLATWNLRSDTKRYYHLYGMEGLLELCTDSGFKVLDHGTEEESLFAVLEK
What are the official names of this protein?
Putative methyltransferase ECU09_1500.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: TYSY_METMA
Sequence: MENKFEIGRIIRAKNISDAWYRGLNIIWNHGRVITDERGSQIKEFMDLMVVIENPYTDRIPADTAWNEERLEEYAKQLISGENIQDFEYTYGQRLRNWNGEVDQIEYVIEKLKESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDEKVHLTTLFRSHDFGGAYPANLYGLSKLLEYVAEKVGVEPGVITTVSISAHVYDHDWDMVENIVKGIN
What is the function of this protein?
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
What are the official names of this protein?
Putative thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_MESFL
Sequence: MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEPWTEALLFIAARKEHLEKVIKPYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNILEGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKFKEAVKLAFEELVVKEPNRITVIDASKSPEEVFEETKKVILEKIELWKKEKR
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: KTHY_YERP3
Sequence: MNSKFIVIEGLEGAGKTTARDTVVAVLRAQGINDIVFTREPGGTPLAEKLRDLIKQGIDGEVLTDKAEVLMLYAARVQLVENVIKPALARGSWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARARGELDRIEQESLAFFERTRARYLELAASDASIKTIDASQPIEQVSASISQALAQWLTNQELV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MEN8_SILLA
Sequence: MANNMKSATFCKATWAIFLVALAILVQLKGSEAQAGGCASQLGNLNVCAPYVVPGAVNTNPSQECCAALSGVNHDCMCNTLRVASQLPSSCNLAALNCGN
What are the official names of this protein?
Protein MEN-8.
What is the protein family that this protein belongs to?
Belongs to the A9/FIL1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_CHLCV
Sequence: MSRSLRKGPFVDHHLIKKVRAMNLLEKKSPIKTWSRRSMITPEMIGHTFEVHNGKKFLTVFVSETMVGHKLGEFSPTRIFKSHPVKKG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: AB12A_ARATH
Sequence: MVNPSPASFWTQANALLRKNLTYQRKHIWTNVRLILVPLFLCLILLAIQQVLDALMKGVSDMSNCGGNVTLPGGICPIPNPPSLPPMLQIPQHELRSVKTDFFSYKDLPDKLCRETGSCPVTILFTGDKLPLGKALSANIFSTSFVVNSSDLLPTLANNVLGSTEAAGEDNYEDPGIASDLPIYSIQPSCSANSTWPLSLGQIQTAVKCVQGLCLWRNNSVEVNDELFKGSWRGNPAGMPNEIVAAYDLMSTDRKNFNVTIWYNSTYNDEFATGQALKLVRVPRSINLISNAYLKFLKGPGTRILFEFLKEVPKEETKMNQDIASLLGPLFFTWVVLLLFPVILTSLVYEKQERLRIIMKMHGLGDGPYWMISYAYFLTISMLYVISLVGFGSAIGLKYFRRNDYSIQFVFYFIYSNLQISLAFLVSSIFSKVKTVTVIAYILVYGTGLLGSFLFQKMIETQSFPEEWILAMELYPGFSLYRGLYEFSQYASRGNGMKWQDLSDSGMGEVFCIMSVEWFLALIVAYYIDQVFTSGKHPFFFLVNLFKSPSSLPRRPTVQRLDSKRVFIDMDKHDVTQERESVQKLRNEGSTGHAILCDNLKKVYPGRDGNPPKMAVRGLYLSVSSGECFGMLGPNGAGKTSFISMMTGLLKPSSGTALVQGLDICKDMNKVYTSMGVCPQHDLLWETLTGREHLLFYGRLKNIKGSDLTQAVEESLKSVSLYDGGVGDKPAGNYSGGMKRRLSVAISLIGNPKVVYLDEPSTGLDPASRKNLWNVIKRAKQNTAIILTTHSMEEAEFLCDRLGIFVDGGLQCIGNSKELKSRYGGSYVFTMTTSSKHEEEVERLVESVSPNAKKIYHLAGTQKFELPKQEVRIAEVFRAVEKAKANFTVFAWGLADTTLEDVFIKVARTAQAFISLS
What are the official names of this protein?
ABC transporter A family member 12, ABC transporter ABCA.12, AtABCA12, Putative ABC2 homolog 16.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MUTS2_CLOPE
Sequence: MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRKGNPPFEGLYDVKEAITRAEKGGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEGMREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSLKEKNSSIRDKVNSIVRSNTQYLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLKERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVIDLMDARHPLIPKDKVVSSDIYLGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPASENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIMEKANNKSFVLFDELGAGTDPTEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLIGVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAILRNDAEKYKNRYKEKFERIESVRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGISSDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKIEVGMEALLPSINQKVIVLSKPDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEEACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGVTVVILK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: DRE2_SCHJY
Sequence: MTTTIVLASPNYAANESKFATSLAKFQANSTDASHQRDIHMIDRIAGNLASLTVNAYDRGLLFLDESTTLEEIKAILPKLFAAVHPGAALSVDGVFAKELADAFERESLLAGWMIESKGPFVLRRPAQVEAVPLKLSTKKSAGASVGVKLDFLFKKPEKQNTLSKNDVLKAAQEEEEGEDDLYDEDALVSDEETQLGKDVLAPPSTCSKPGKKKRCKNCTCGQREQDEAEAAAASAAAPKAVKLTDTMEIDFTELLKSKNAVSSCGSCYLGDAFRCSGCPYIGLPAFKPGEQVLISENRDKLSWMADDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein dre2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: Y1047_BRUC2
Sequence: MSDKTPRKPTAFRLEQPARVSAASEQEEPRRPRAVKDLEQITPQADVFDLTDDEAAELEILDPAFEAPERKGWSLSRILFGALGILVSFAIGIWTEDLIRALFARADWLGWTALGVAMVALAAFAAIILRELVALRRLASVQHLRKDAADAAERDDMAAARKAVDALRTIAAGIPETAKGRQLLDSLTDDIIDGRDLIRLAETEILRPLDREARTLVLNASKRVSIVTAISPRALVDIGYVIFESARLIRRLSQLYGGRPGTFGFIKLARRVIAHLAVTGTIAMGDSVIQQLVGHGLASRLSAKLGEGVVNGLMTARIGIAAMDVVRPFPFNAEKRPGIGDFIGDLARLNSDRNARK
What are the official names of this protein?
UPF0283 membrane protein BCAN_A1047.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCPA_LISMC
Sequence: MVEMNFKVDAFEGPLDLLLHLIGQLEVDIYDIPMAEITDQYMEFVHTMQEMELDVASEYLVMAATLLAIKSKMLLPKQELEIDYDTLEEEEDPRDALVEKLMEYKRFKEAAKELKEKEAERSFYFSKPPMDLAEYDDGTKVAELDVSLNDMLSAFNKMLRRKKLNKPLHTRITTQEISIDQRMDSVLEKLNLQVNHRLRFDELFEEQTKEQLVVTFLALLELMKRKLVEVEQAESFADLYVQGKGEEIS
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: NS1_I89A7
Sequence: MDSNTTTSFQVDCYLWYIRKLLSMRNMCDAPFDDRLRRDQKALKGRGSTLGLDLRVATMGGKKIVENILKSEADENLKIAIASSPAPRYITDMSIEEISREWYMLMPRQKITGGLMVKMDQAIMDNIIILKANFSVLFDQLDTLVSLRAFTEAGAIVAEISPIPSMPGHSTEDVKNAIGILIGGLEWNDNSIRASENIQRFAWGIRDEDGGPPLPPKQKRYMARRVEPKV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: CAPP_NEIMF
Sequence: MQLHILNNPKDAALAADAEFLKQSLFNLLHEEASPLVVETVKLLSTSDDSAALIEKVLPQLDEQQTHDLTLACGLFAQILNIAEDVHHERRRQIHEEAGRGGAEGSLTETVRRLKAGKADGKSVQRQLDNTSVTAVLTAHPTEVQRQTVLSFNRRIRALLPQRERCTNADALARLRREIDTILLGLWQTSETRRHKLSVNDEINNGVSIFPMSFFEALPKLYRNMEHDFQMVYPDVCVPNILKIGGWIGGDRDGNPFVSAETLRFAFRRHADAVFRFYRGELDKLYRELPLSIRRVKVNDDVMALAALSPDEELARTEEPYRRAIAYIMARAMGKARALGLGMGCKFGFLEPYASAQEFLDDLKKLQRSLIDNGSRLLAEGRLADLIRSVSVFGFHMMPLDLRQHAGKHADVVAELFQHAGLEDYNSLNEEQKQAVLLRELSHQRPLYSPFITYSDHTRHELAIFNEARKIKDEFGEDAVTQSIISNCEQPSDLLALALLLKESGLLAVENGKPHSRINIVPLFETIEALENACPVMETMFRLDWYDALLESRGNIQEIMLGYSDSNKDGGYVTSSWCLYQAELGLVELFKKYDVRMRLFHGRGGSVGRGGGPSYQAILAQPAGSVAGQIRITEQGEVITAKYADPGNAQRNLETLVAATLEASILPDKKDPDAKLMQALSDVSFKYYRELITHPDFIDYFLQTSPIQEIATLNLGSRPASRKTLARIQDLRAIPWVFSWMQNRLMLPAWYGFGSAVETLCEGNPDTLTALREHAQSNPFFQAMLSNMEQVMAKTDITLAENYAGLSESPDKAKIIFGMIKEEYRRSRKALLDLLQTEELLRDNRSLARSLALRIPYLNALNGLQVAMLKRLRKEPDNPHALLMVHLTINGVAQGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: RPA43_HUMAN
Sequence: MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALSPRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADFVIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFEVFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEVDSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSSGYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA43, DNA-directed RNA polymerase I subunit F, Twist neighbor protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DTD_BACTN
Sequence: MRIVVQRVSHASVTIEGQCKSSIGKGMLILVGIEESDGQEDIDWLCKKIVNLRIFDDESGVMNKSILEDGGEILVISQFTLHASTKKGNRPSYIKAAKPEISVPLYERFCKDLSRALGKEIGTGTFGADMKVELLNDGPVTICMDTKNKE
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LLR1_MOUSE
Sequence: MRLPCEVEVRSCHLPTLGLKSRGKGVRAVVSLCQAPGRNELQPEARAEPGGHACLLVSTMKDRQGTSYKLRENIEQLFTKFVDEGKATVRLKEPPVDICLSKANPGNLKTLLSAMRLAHRGCDVNTPLSTLKPVKTSEFEKYKTKMVITSKKDYPLSKNFPYFLEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTLQKSLHSLDLSKNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNTFEKPEVIPIIKLQVPLTLLESCEQAVLFYRIPYGPDIIPYHLCQDLDTAKTCVCGRFCLQSFIQGTTTMNLHSVAHTVVLVDSMGRTEAPVVSYFCSLTCFVKSSDMLN
What is the function of this protein?
Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:33590678).  ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678).  May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (By similarity).
What are the official names of this protein?
Leucine-rich repeat protein 1.
Protein: YR852_MIMIV
Sequence: MKNIAVIFPNQLFEISYLPYDPDSIDVYIIVEDSLYFSDNERFLRFNLLKLIYLRAAMKYYYDYLTDRGYDVIYLDWTGEPSLVFEYVSKNYGSCNLNIIDPVDYLLEERIAEFSDSYNQKIIYYESPGFILTNLDLKQYTGSKQGANKKFFQHSFYAWFRKKFDILMDGNKPIGGKYSYDKYNRQTIPNKIFISF
What are the official names of this protein?
Uncharacterized protein R852.
Protein: PDXY_BURL3
Sequence: MKNVLSIQSHVIYGHAGNSAAVFPMQRLGINVWPLNTVQLSNHMQYGHWAGSAIDAAKMEQLVDGIAAIGALKRCDAVLSGFLGSPPQARAAVEIVRSVKAMNPNAWYFCDPAMGQTGGIRPEPGVEEFMVQEMPALADGMSPNHTELQKLAGRRIETVAEAVEACRALIRRGPQIILVKHLHDRNSPADRFNMLAVTETEAWIGQRPLYAFPRHPVGVGDLTSAIFVACRLRGDSVRAAFEHTLAAVHAVVKATYDARRYELELVAAQDEIARPSEWFGAWVTDA
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: TONB_PSEPU
Sequence: MTKTRHNLARYSGSLALVLGVHAVAVLLTLNWSVPQAIELPPAAMMVELAPLPEPAPPPPPKAAPQPPAPVEELPLPKLVEAPKPKIAIAKPPKPKAKPQPPKPEKKPEPPKEAPPTEEVVDAPPSNTPPQKSAAPAPSIASNSNALPTWQSDPVRHLAKYKRYPEDARRRGLQGINRLRFVVDAEGKVVSYAMAGGSGSAALDRATLEMIRRAGTVPKPPPELLNNGTIEVVAPFVYSLDRR
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.