PharMolix/UniProtQA huggingface dataset:
Protein: RL19_TRIEI
Sequence: MKAQEIISSIEAEEIEKLKQNSKKKIPLLYVGDTVKVGVKIIEGGKERVQPYEGTIIAMRNGGINETITVRRVFQGVGVERVFLLHSPRIANIKLIRRGKVRRAKLYYLRGRVGKATRVKQRFDRSL
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: Y1266_ARCFU
Sequence: MELTTPERVLFETEVYEIDDDLKVKRGNVKITESRIMFRSNGNAKLLYISGIQMVEIKKENRWGFFAGGLIFLVSSAIMYLLGLEFGVGSFTSALMLFVLPTAFLFVSLLLLYWWFVTRSYLLDMHTNFGRKLRIRSKSKEDLYEIANAVELVKMGAVRMLQRKERQFV
What are the official names of this protein?
Uncharacterized protein AF_1266.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNFG_ALIFM
Sequence: MLTTMKKSSLVLALFAIAATALVTITYALTKDQIAYQQQQQLLSVLNQVVPKEQHDNELYKACILVKNNDALGSKQAMPIYLASLNGKHSGAAIEAIAPDGYSGNIKIIVGVDSDAIVTGVRVLSHQETPGLGDKIDIRITRWVDAFLGKTVESSEDKNWAVQKDGGQFDQFTGATITPRAVVKAVKRAVWFYKTHQEELLTLPLNCETK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GUAA_PELUB
Sequence: MSLSNNLSKILIIDFGSQFTQLIARRVRELGVFSEIVSHKKIKIAQITKDNIAGIILSGGPLNVYENDKFKFDKKILKLGIPILGICFGHQILSKLLGGKVKKSKHREFGLATINKVSNSTLTKNFFNKNNRSDVWMSHADQVSKMPKNFKIIASTKNSKLTIIENIKENFYGVQFHPEVTHTNKGKILLRNFVFLICKIKKNWSSKDQKLKLINEIKDQVGDNKVICGLSGGVDSSVVAQLLSKAIGKNLTCIFVNNGLLRKNEEIQVVNTFKKKLKINLIYVNAEKEFIRKLTNVSDPEKKRKIIGNLFIKIFERYANRIKNVKFLAQGTLYPDLIESKSVTGSQTSKIKSHHNVGGLPKRMKLKLVEPLKFLFKDEVRKLGLELNLSNDIISRHPFPGPGLAIRMPGIITNEKIKILKEADFYFIKALREHGLYDKIWQAYAALLPVKTVGVMGDNRTYEHICLLRAITSEDGMTADFFDFPKGFMQSISNQIINNIRGINRVVYDVTSKPPSTIELE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RF3_ECOLI
Sequence: MTLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYHDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVYHLYKDETYLYQSGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELELVKGASNEFDKELFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPMPRQTDTRTVEASEDKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLRQVRTAKDVVISDALTFMAGDRSHVEEAYPGDILGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPISNNDLIVGAVGVLQFDVVVARLKSEYNVEAVYESVNVATARWVECADAKKFEEFKRKNESQLALDGGDNLAYIATSMVNLRLAQERYPDVQFHQTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor RF3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA21_CERGO
Sequence: HLFQFREMIKEMTGKEPVVSYAFYGCYCGKGGRGKPDAT
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows high myotoxic activities, induces mild edema, and shows cytolytic, and anti-coagulant activities, as well as intracerebral lethal effect (PubMed:10698689, PubMed:1524423).  Does not induce lethality at a dose of 5 ug/g, when intravenously injected into mice (PubMed:1524423).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:1524423).
What are the official names of this protein?
Basic phospholipase A2, svPLA2, Myotoxin I, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACDH6_RHOJR
Sequence: MEPINAAIVGPGNIGTDLLAKLERVDSIAVQYVVGVVESDGLERARAKGISASAGGVDWLLEQDPLPEIVFEATSAKAHQLNAPRYHELNIQAVDLTPAHIGPMVCPPVNLTHHIDAPNVSMITCGGQATIPMVHAVSRVSAVPYAEIVASVASRGAGPGTRANIDEFTQTTGQAVSEVGGAARGRAIIILNPMEPPMIMRDTVYCMIDADADRDAISESVHRMVTEVQAYVPGYRLRADPQFDDPKDGWDGHGRVAIFLEVEGNGDYLPKYAGNLDIMTAAAARVGDSIARNRMGVPA
What are the official names of this protein?
Acetaldehyde dehydrogenase 6, Acetaldehyde dehydrogenase [acetylating] 6.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: ISPG_MACCJ
Sequence: MPEITHRKNTRPVKVGDLTIGGSNELVIQSMTTTKTHDVEATVAEIKRLEEAGCQIVRVACPKEEDALAIAEIKKQINIPLVVDIHFDYKLALLAIEGGADKIRINPGNIGRREKVEEVVKACKAKGIPIRIGVNAGSLEKHILKKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYTKAAQAFDYPLHLGITESGTLFAGTVKSAAGLGAIMSLGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISTIKAPLKVAVLGCAVNGPGEAREADIGIAGARGEGLLFMKGKTVRKVPEETMVEELKMEIDKLAEEYFKKQEAEKLANAEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: COX1_MAMPR
Sequence: MFANRWLYSTNHKDIGTLYLLFGAWAGMVGTAFSILIRAELGQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGTGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILSAINFITTIINMKPPAMSQYHMPLFVWSILVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMVSHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLNHTWAKIQFLVMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTAWNTASSMGSFISLVAVILMVFMIWEAFASKREVSVMELTTTNVEWLNGCPPPHHTFEEPAYVKSNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPB_PROMS
Sequence: MVATPSISSQTKGVVRQVIGPVLDVEFPAGKLPKILNALRIEAKNPAGQDIALTAEVQQLLGDHRVRAVAMSGTDGLVRGMEAIDTGAPISVPVGEATLGRIFNVLGEPVDEQGPVNTKDTAPIHRAAPKLTDLETKPKVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINADDLTQSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFVDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGELQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYKTARAVQSTLQRYKELQDIIAILGLDELSEEDRLTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEDTIAGFNMILSGELDDLPEQAFYLVGNIDEVKAKAEKIKSEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: Y2418_PSEAE
Sequence: MKKVLGIYGNANRHWVGDGFPVRSLFSYNTLGQHISPFLLLDYAGPADFPPAQQRRGVGQHPHRGFETVTIVYQGEVEHHDSTGAGGRIGPGDVQWMTAASGILHEEYHSERFRSTGGTLEMVQLWVNLPSSDKMNPPRYQTLLDADIPRVGLPDRAGELRVIAGRYGRHQGPALTHSPLAVWDVQLKAGKHLALDLPKGHTCAVVVLRGTLAVGDEIVREAQVALLDRDDPRLELEANNDVQLLVLSGEPLDEPIIGYGPFVMSSREEIDQAIEDFENGRFIRAH
What is the function of this protein?
Putative quercetin 2,3-dioxygenase.
What are the official names of this protein?
Putative quercetin 2,3-dioxygenase PA2418, Putative quercetinase, Pirin-like protein PA2418.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: SYF2_MAGO7
Sequence: MSDSTPTEAAVAESNTAGNEATTNSDKASPETTTTSTTEPGNTAKTAAAERMARFRALQARAKTSSDQNLKAATAESRREASDPSQLTALHRRHAIASHKILKADVEESGGDFERKRAWDWTAEESERWDKRVKKKEAARDNNAFQDYRHEAEKIYKRQLKNMPPDMERYAKDKMAAIDKAAAAGTLDIVETEDGELIAVDRAGTFYSTTDSTDFAKNKPDKEAIDRLVNDMKKAEDVAAKKRKARMAKNGEDDDVTYINDKNKQFNQKLARFYNKYTAEIRESFERGTMI
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SYF2.
What is the protein family that this protein belongs to?
Belongs to the SYF2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL31_HALMA
Sequence: MSASDFEERVVTIPLRDARAEPNHKRADKAMILIREHLAKHFSVDEDAVRLDPSINEAAWARGRANTPSKIRVRAARFEEEGEAIVEAETAE
What is the function of this protein?
Binds to the 23S rRNA.  Located at the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L31e, Hl30, L34.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: RL36_EXIS2
Sequence: MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: GBA1_BOVIN
Sequence: MELSSPSREEYPMPRGRVGIMAASLMGLLLLHTVSWVSGARPCSPKSFGYSSVVCVCNGTYCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTIQANRTGTGLLLTLQPDQKFQKVKGFGGAMTDAAALNILALSPAARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRTYTYDDSPDDFQLLNFSLPEEDVKLKIPLIHQALELANRSVSLFASPWTSPTWLKTNGAVNGKGTLKGQAGDLYHKTWARYFVKFLDAYAEHKLRFWAVTAENEPTAGLLTGYPFQCLGFTPEHQRDFIARDLGPILANSTHRDVRLLMLDDQRLLLPRWAQVVLADPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMRYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDIAKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASKKSDLDTVALLRPDGSAVAVVLNRSSKDVPLTIKDPAVGFMETVSPGYSIHTYLWRRQ
What is the function of this protein?
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose.  Plays a central role in the degradation of complex lipids and the turnover of cellular membranes.  Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation.  Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol.  GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine).  Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide.  Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol.  Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers.  Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
What are the official names of this protein?
Lysosomal acid glucosylceramidase, Acid beta-glucosidase, Beta-glucocerebrosidase, Cholesterol glucosyltransferase, SGTase, Cholesteryl-beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Lysosomal cholesterol glycosyltransferase, Lysosomal galactosylceramidase, Lysosomal glycosylceramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
Protein: RL35_PROMM
Sequence: MPKLKTRKAAAKRFKATVTGKFMRRRAFRNHLLDHKSPKLKRHLATKAVVDERDAENVRLMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PYRD_DEIDV
Sequence: MYRRVIKPALFRLDAEDAHHLTVNALALMSRLPGWPAAARRLSAPADSRLMQTLWGHTYASPVGLAAGLDKNGVAVPAFSALGFGFVEVGTVTPQPQPGNDRPRLFRLPPDEALINRMGFNNAGAAALRGQLSRLGRRTVPVWVNIGKNKLTEEAAQDYVACVQELYDVADAFVVNVSSPNTPGLRALQASAELEALLRAVLNETEAQRLRTARRAPPVLVKLAPDLHPADFEASVQGALNAGVQGLIVSNTTLSRDGLTHAHREQAGGLSGRPLTGRSTALVQDAYRLTRGAVPVVGVGGIFSADDAYAKIRAGASLVEVYSSLIYEGPGLPARIHRGLGQLLERDGISHVRDAVGADA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRM1L_RAT
Sequence: MENMAEEELLPQEKEEAQVRVPTPDSAPVPAPAADTALDSAPTPDSAPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNLENIQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGSRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYISASTAKSSNEVLKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDGLEDCSTAGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGVEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYKQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSVHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINVAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDASLTQFKSILLKYSTPTYTGGQSEGQVPAPEDTVTDPVELSVNDKAEVSGCRRW
What is the function of this protein?
May play a role in motor coordination and exploratory behavior.
What are the official names of this protein?
TRMT1-like protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: Y909_RICBR
Sequence: MLKSLKQHTTTSLVLQHFANAGQAAVNCGMYAGLAATYGGKAMFQGVLGLCAYKEFAGEVMTGHAFGFAMPKVLSGLVAGVAGAIYHHPTAVMATFVTAAILTSPENAYETVKNAAFTGLEAAHFVYENTAGIANGVAGICNLVYENLPSHSEVSTSNICNRR
What are the official names of this protein?
UPF0416 protein RBE_0909.
What is the protein family that this protein belongs to?
Belongs to the UPF0416 family.
Protein: YDJC_THEPX
Sequence: MKYLIVNADDFGLTKGVNKGVVECYKNGILRSTSIMCNMPYAHEALEIKELCPDLGFGIHITLDAGKPLSSPEKVNTLVDERGYFKRGFPHSLDDADVDQIRIEIEEQIKKAFSLGVTITHMDSHHHAQSHPRVIDVFIEMAYKYNLPVRSTPLDREIIIKAGLKTVDNFIYNFYDEGVKKENLLSILGSLKEGITEIMSHPAYVDDELMNISSYNTKREIERTILTDKDVLQFILDNNILLANYSILK
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: MSRB_HERAR
Sequence: MTEKVIKTDAEWRAMLDDEEYDVTRHAATEAPFSGRYWDHHEHGIYTCVCCNTPLFASDAKFDSGCGWPSYFTALNPDNVKEKIDRAYGMIRTEVICNVCDAHLGHVFNDGPPPTGLRYCINSASLRFDATPDLNES
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: KDSA_XANCB
Sequence: MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGINFIFKSSFDKANRTSGTSFRGPGLEEGLKVLDAVKKQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFIKNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMVCERGASFGYNNLVSDMRSLSVMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKALSDGPNAWPLDRMEELLETLMELDAVTKKHGFARFA
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4A3_MACFA
Sequence: MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPARELAVQIQKGLLTLGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase.  Involved in pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.  The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC.  Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex.  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.  Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.  Involved in craniofacial development.
What are the official names of this protein?
Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic translation initiation factor 4A isoform 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites.
Protein: TRAF4_MOUSE
Sequence: MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHRCPKLAMGRHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRASVELPRKILS
What is the function of this protein?
Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis.  Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation.  Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation.  Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair.  In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity).  Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors.  Required for normal skeleton development, and for normal development of the respiratory tract.  Required for activation of RPS6KB1 in response to TNF signaling.  Modulates TRAF6 functions.  Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (By similarity).
What are the official names of this protein?
TNF receptor-associated factor 4, Cysteine-rich motif associated to RING and Traf domains protein 1.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. B subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein: MSHR_VULLA
Sequence: MSGQGPQRRLLGSLNATSPTTPHFKLAANQTGPRCLEVSIPDGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAGALAAQAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQHARGIARLRKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHPICGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.