PharMolix/UniProtQA huggingface dataset:
Protein: NU6M_PROWI
Sequence: MDFLFYIFSSLTLISGSLVIQARNPVHSVLFLVLVFFNAAGLLVLLGLDFFALIFLVVYVGAIAVLFLFVVMMLNIRITEISEKRLRYLPVGGVLGVLFLFEICILIDNDCIPLLSYDIENTALLANYNQLSFIDWRMYLSTSHTIDALGSLLYTYYFYFFLVASLILLVAMIGAIVLTMQKGIRIKRQQVFLQNTRDFAKTIRKVA
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: KTHY_XYLFT
Sequence: MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFLALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: NAMPT_PIG
Sequence: MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKIRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYKEHFQDDVFNEKGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENIAFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPGGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIELEAAPH
What is the function of this protein?
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD.  It is the rate limiting component in the mammalian NAD biosynthesis pathway.  The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma.  Plays a role in the modulation of circadian clock function.  Plays a role in the modulation of circadian clock function.  NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
What are the official names of this protein?
Nicotinamide phosphoribosyltransferase, NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1 homolog, PBEF, Visfatin.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Protein: DUT_PELPB
Sequence: MLKVKIVRLNKQASLPVYATAHAAGMDISACIEAPITIQPSTTALIPSGFALELPEGYEAQLRPRSGLALRSMISLPNTPATIDADYRGEVKVILINYGKEPFLVSHGDRIAQMVVAKVEAVRFEEVEELGSTVRGEGGFGHTGTGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ARGB_BRASB
Sequence: MTDATTISPLDQARILSEALPHMQEYDDETIVIKYGGHAMGDEDTAKAFARDIVLLEQTAINPVVVHGGGPQIATMLKRLGIVSEFAAGLRITDAATIEIVEMVLAGSINKQLVGYINEAGGKAVGLCGKDGNMVRAVKATRTMVDPDSHIEKVVDLGFVGEPDKVDLTLLNQLIGYELIPILAPLATSKEGQTFNVNADTFAGAVAGALKAKRLLLLTDVPGVLDKSKKLIPELSVKDARKLIADGTISGGMIPKVETCIYALEQGVQGVVILDGKVQHAVLLELFTNQGTGTLIHK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_THET2
Sequence: MLGRLYLVVTPRPGWSLEATLDRTERALAGGVEVVQLRAKDWEARPTLALGERMLALARRYGVPFFLNDRPDLAALLGADGVHLGQNDLTPEEARRFFAGMVGRSTHAPEQALRALEEGVDYLSVGPVWETPTKPGRPAAGLAYVRWAAENLGEKPWYAIGGIDLGNLDQVLEAGARRIVVVRAILDAPDPERAARALRERLYGVA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: VKTC1_DABSI
Sequence: MSSGGLLLLLGLLTLWAELTPISGQDRPKFCNLAPESGRCRGHLRRIYYNPDSNKCEVFFYGGCGGNDNNFETRKKCRQTCGAPRKGRPT
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin.
What are the official names of this protein?
Kunitz-type serine protease inhibitor C1, BPTI-1, Trypsin inhibitor 1, Trypsin inhibitor C1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y9232_DICDI
Sequence: MALFNSISKIGSINSKSNTLINSTMNGNAFGSNEISVLANTNVNAATNTNLSVAGITLVNAKTNTNALKFKSITKCNSCCNY
What are the official names of this protein?
Putative uncharacterized protein DDB_G0291089.
Protein: NRDR_STRP4
Sequence: MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVEERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: NPT2B_BOVIN
Sequence: MAPWPELENSQPTSEKYTVKADGEQSAKPEKAKETEKDDTGTPITKIELVPSHSTATLIEEPTEVEDPWDLPELKDTGLKWSERDTKGKILCVFQGIGKFILLLVFLYFFVCSLDVLSSAFQLVGGKVAGKFFNNNSIMSNPLAGMVIGVLVTVLVQSSSTSTSIVVSMVASSLLPVHAAIPIIMGANIGTSITNTIVALMQAGDRKEFRRAFAGATVHDFFNWLSVLVLLPLEAATGYLERLTNLVVESFHFKNGEEAPELLKVITDPFTKLIIQLDKSILNQIAMNDESVQNKSMIKIWCKTFTNVTERNVTVPSPENCTSPSLCWTDGLYTWTIKNVTYKENIAKCQHIFVNFNLSDAIVGTILLITSLLILCTCLILIVKLLGSVLRGQVAAVIKKTINTDFPYPFSWVTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVISIQRAYPLTLGANIGTTTTAILAALASPGSTLKSSLQIALCHFFFNISGIILWYPIPFTRLPIRLAKGLGNISSKYRWFAIVYLIVFFLLIPLAVFGLSLIGWPVLVGVASPIVLVILLVVVLKILQSFCPGSLPQKLRSWDFLPFWMRSLEPWDKLITSLTSCFQMRCCCCCRVCCRLCCGLCGCSKCCRCTKCSEDLEEGKDEPVKSPEAFNNLAMDKEAQDGVTKSEVDASGTKIVSSVTAL
What is the function of this protein?
Involved in actively transporting phosphate into cells via Na(+) cotransport.
What are the official names of this protein?
Sodium-dependent phosphate transport protein 2B, Sodium-phosphate transport protein 2B, Na(+)-dependent phosphate cotransporter 2B, Sodium/phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, NaPi-2b, Solute carrier family 34 member 2.
What is the protein family that this protein belongs to?
Belongs to the SLC34A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of enterocytes.
Protein: NADE_STRP7
Sequence: MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQPDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQELGADPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: VL2_HPV19
Sequence: MARARRTKRDSATNIYRTCKQAGTCPPDVINKVEQTTIADKILQYGSAGVFFGGLGISTGKGTGGATGYVPLGEGPVRVGGTATVIRPSLVPDTIGPSDIIPVDTLNPVEPTTSSIVPLTEASGSDLLPGEVETIAEVHPTPSIPSTDTPVTTTSSGASAVLEVAPEPVPPSRVRVTRTQYHNPSFQILTESTPTQGESSLADHILVTSGSGGQTIGSSGSDLIELQEFPTRYSFEIEEPTPPRQSSTPIQRLRTAFRRRGGLTNRRLVQQVAVDDPIFLTQPSRLVSFQFDNPAFEEEVTQIFEQDLDNFREPPNRDFLDVQTLGRPQYSETPSGYIRVSRLGQRRTIRTRSGAQIGSQVHFYRDLSTIDSEDPIELQLLGQHSGDASIVQGNTESTFININIDENPLAEDYSITANSEDLLLDEAQEDFSGSQLVVGGRRSTSTYTVPQFETTRSGSYYTQDTKGYYVAYPEDRSTSKDIIYPMPDLPVVIIHTYDTSGDFYLHPSLRKRFKRKRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: PAN_METMA
Sequence: MRSHLVKPGSVYDGIEPGELGETTESVQDRVRQLESRNSFLEEQCSQIESEKRYLENQKIKYEREIRKLQSELDRMKTSPLIIGTVIDVIKNDRIIVRSSNGPQFLVNVSQYIDEKKLLPGAKVALNQHTLAIAEVIPSTEEPFVAAMEVIESVEVDYDQIGGLDEQIQELQEAVELPLTSPERFARIGIEPPKGVLLYGLPGTGKTLLAKAVAHRTNATFIRVVGSELVQKYIGDGSKLVREIFEMARKKAPSIIFIDELDSIAARRLNETTGADREVQRTLMQLLAEMDGFDKRKNIRIIAATNRPDVLDPAILRPGRFDRLVHVPMPGIEARGKILKIHCEKMTLAEDIDFKKLAKATEGMSGADLKAIATEAGMFAVRRDKELVEMEEFLEAVEKVSMAADTQKMMPSNLPETMFV
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_PSESM
Sequence: MSKEPDRLFAQPLPQVPDFAFNEDVVRVFPDMIKRSVPGYPAIVENLGVLAAQFAQPDTVLYDLGCSLGAVTQALRRHVRSDGCEVIAIDNSTAMVERCREYLNAQNSMFQELLPVQVIEGDILALAFKPASVVALNFTLQFVAPEQRLALLGRIRGALVPGGALILSEKLRFNDEQEHALLTDLHIAFKRANGYSDLEIAQKRSAIENVMKPDSLEEHRQRLLAAGFSKVVPWFQCLNFASLIALP
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: ACP_STAAC
Sequence: MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENDA_NATPD
Sequence: MEGHLSDGLVEVGPNGRERYYDSSGYGRPDGAGVRLAPVEAAYLLARGDLDAVDGMGLEAFLADTPDLVVPFLVYRDLRERGFYVSPALEGWVADHAGIDFVVHPRGDGPWDGTVAYRVRVVDERGSVRLDSLGDVVLAVVDEESELTYLETDRPAVDGTSGLEADLTADGVLLEDRVLCWDAPPALYEQGFYGQRMDREDGPLQLSLLEAAHLAATGVLSVAGGAAAVEARGRDAEGERFDRRLTVYRTLRERGVVPKTGFKFGADFRTYADVDSVSELGHSELLVRVLPADATLSPRDVALDVRLAHGVRKRMVFALVDDGDEIRWVSVSRLTP
What is the function of this protein?
Endonuclease that removes tRNA introns.  Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
What are the official names of this protein?
tRNA-splicing endonuclease, tRNA-intron endonuclease.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
Protein: CBPC6_HUMAN
Sequence: MAEGSQSAPEAGNDMGNDDAIGGNVSKYIVLPTGYCGQPKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGAEQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREYLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWVHPTLHGVKQLIVQMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQAIFPKLLCQNAEDFSYSSTSFNRDAVKAGTGRRFLGGLLDHTSYCYTLEVSFYSYIISGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNPVVEKVAIPMPRLRNKEIEVQRRKEKSPPYKHPLLRGPASNYPNSKGDKKSSVNHKDPSTPF
What is the function of this protein?
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins.  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein.  Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate.  Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.  Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity).  Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216).
What are the official names of this protein?
Cytosolic carboxypeptidase 6, ATP/GTP-binding protein-like 4, Protein deglutamylase CCP6.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells.
Protein: SULH3_SCHPO
Sequence: MSSPSENHLLGPKTSFIDNRTSTSRPLHEIPSYQSLARRSSTWKRANIPQQKPSLVRRINYYIPVLHWLPNYSLRNIIWDVLAGCSTACLSVPIALSFAQTFLGVPPIYILTGTAIGPILYCLFTACPLISIGPEAGMCLLIAENIHQRVLSKADVPQETAILVTGLIAFIAGIINLAAGLFRLGFLDALVSPVLLRGCILSISMIIMINQGSVFFGFSGVKYKGSDFPIDKLMFLIRNMSKANIYTTILSCITISLLIGCRNLKSKLSAKYPRIVSIPDAVIILLLGSFLSKKFDWHSNYGIAILGEIKTTILLPKLPLPEKNKLHFITQSLQTGVMCSFLAFIDTVIAVKAISLQTNNLIRSNRELISLGAANIGSSLFCGLPICGGYLRTKCNIMSGARTQVATIACSVLILLATFFIMPVFSTVPTCMLASMVVSLGVSLFADAAVEIFKLARIRVWWELGIIFSIATCTMMFGLETGIIFGLSITVMQIIRHSTRSRIMFRSPTSNGTAEFILEDAASTLSHRTNPSSTAVESAPRILVVRIPEPLFFANVSQLEDRLNRLEKYGHPRMHPGETPYRRIEDIEVVVFDMVGVSSIDSSALFAFQRILKEYVEHQVEVHLVSLDPQVLHIFEKHGLLDLIGGYDHVQDSIKKVDALCDIELGV
What is the function of this protein?
Possible sulfate transporter.
What are the official names of this protein?
Probable sulfate permease C320.05.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein: RBL_IPOPU
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYRIERVIGEKDQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFVEQDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIRQACKWSPELAAACEVWKEIRFEFKPVDTLDPDGN
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y338_STAAR
Sequence: MASLKNKHFMIGLSLTFIVALFSFLAAKLPILDKVGALTIAILIAILYRHFKGYPEQYSSGITFSSKYLLRFAIILYGLKLNIFDIIGQGSRLLAIDVGVVIFSIVMMLFVNKLLRGDKNIALLLGVGTGVCGAAAIAAVAPIFKSREKDTAISIGIIALIGTIFSLIYTAIYAIFSMTTNVYGAWSGVSLHEIAHVVLAGGFGGSDALKIALLGKLGRVFLLIPLTIVLILIMRFRSSESSSKGRISIPYFLIGFVIMALVNTYVTIPSVLLNILNTVSTICLLMAMVALGLNVAFKDLKNRALKPLMTIIITSICLSSLAFIVVHWLYS
What are the official names of this protein?
UPF0324 membrane protein SAR0338.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHRM_DROME
Sequence: MKMRNHKENGNGSEMGESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSASVAGSVQDDLPHHNSSSSQLGQQHGSSLDQCGLTQAGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEGYHSYVSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSSNNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLSPASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPSPPPPLEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSNLYNPDVPLRLAKRDVGTSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDALVQSDC
What is the function of this protein?
Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction (PubMed:20549743, PubMed:22493320).  During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826).  May be involved in the assembly of microtubule arrays during cell elongation (By similarity).
What are the official names of this protein?
Protein Shroom.
What is the protein family that this protein belongs to?
Belongs to the shroom family.
What are the subcellular locations of this protein?
[Isoform D]: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=In adherens junctions, enriched in discrete spots and in tricellular junctions (PubMed:20549743, PubMed:22493320). In adherens junctions, localization requires Rho1 GTPase activity and interaction with the F- actin cytoskeleton (PubMed:20549743, PubMed:24535826). SUBCELLULAR LOCATION: [Isoform F]: Apical cell membrane; Peripheral membrane protein. Note=Localization to the apical cell membrane depends on N-terminal region (PubMed:20549743). Excluded from the lateral membrane (PubMed:20549743).
Protein: MPC1_SCHPO
Sequence: MNASEKLSQKAAQSVTRRFITWLKSPDFRKYLCSTHFWGPLSNFGIPIAAILDLKKDPRLISGRMTGALILYSSVFMRYAWMVSPRNYLLLGCHAFNTTVQTAQGIRFVNFWYGKEGASKQSVFENIMQAAKHPESGTRQK
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Probable mitochondrial pyruvate carrier 1, MPC1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: B1M_SICPE
Sequence: WIMGHMVNDLKLADEFLNDGANSLELDVEFSSSGTAQRTHHGIPCDCFRYCTNSEKFSTYLDYIRQLTTPGNSKFRSRLILLVMDLKLNPLSNRAAYYAGAGVALNLLNHYWQRGESEARAYIVLSLSTIGRADFISGFKNTMEKEGFADKYYDKIGWDFSGNENLQLIRNIFKIYGIREHIWQGDGITNCLPRGDSRLKEALNLRYSPSYVYADKVYTWSIDKESSIENALRLGVDGVMTNHPERLIEVLGKGKYSDKFRLATYDDNP
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SpeSicTox-betaIB3, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.