PharMolix/UniProtQA huggingface dataset:
Protein: DRPR_DROME
Sequence: MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCDELIASQRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIKHKEGYKDPDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNTNLDNVSTASPSSSPKFLK
What is the function of this protein?
Potently inhibits glial cell engulfment of axonal debris produced following axonal injury.
What are the official names of this protein?
Protein draper.
What is the protein family that this protein belongs to?
Belongs to the MEGF family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cytoplasm. Postsynaptic cell membrane. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome. Note=In olfactory receptor neurons, expressed at low levels along the axon but is up-regulated at severed axons following injury (PubMed:16772169). In follicle cells, detected at the cell membrane and in punctate speckles within the cytoplasm (PubMed:22992958). Also detected in follicle cells on the phagocytic cup and on newly internalized phagosomes (PubMed:27347682). In stage 13 macrophages, localizes to punctae around engulfed cell corpses but by stage 15, relocates to the cell cortex (PubMed:27212238).
Protein: BTBDA_HUMAN
Sequence: MAGRPHPYDGNSSDPENWDRKLHSRPRKLYKHSSTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSGNSDLDPDAQNPML
What is the function of this protein?
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated.  Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
What are the official names of this protein?
BTB/POZ domain-containing protein 10, Glucose metabolism-related protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with KCTD20 in filamentous structures.
Protein: TPL_RANTE
Sequence: FVQWFSKFLGRIL
What is the function of this protein?
Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:9022710, PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802).  Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802).  Also displays anti-leishmania activity by damaging parasite membrane (By similarity).  Shows hemolytic activity (PubMed:12133008).  Also shows cytotoxicity against cancer cell lines (PubMed:12133008).  Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (PubMed:16801429) (Probable).  Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570).  In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).
What are the official names of this protein?
Temporin-1Tl, TL, Temporin-L.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Contact and insertion into membrane begin at the N-terminus.
Protein: ILVA_STAES
Sequence: MTVRTKVSTKDIDEAYLRLKNIVKETPLQFDHYLSQKYNCNVYLKREDLQWVRSFKLRGAYNAISVLSNEEKNKGITCASAGNHAQGVAYTAKKLNLKAVIFMPVTTPRQKINQVKFFGDSNVEIVLIGDTFDHCLAQALNYTKQHKMNFIDPFNNVYTIAGQGTLAKEILNQAEKEDKTFDYVFAAIGGGGLISGVSTYFKAHSPHTKIIGVEPTGASSMYQSVVINHSIVTLENIDKFVDGASVARVGDITFDIAKDKVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALEQYKKQIENKTIVCIVSGGNNDINRMKEIEERSLLFEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKTSQNTGTVIIGIQLKHHDDLIQLKDRVCQFDPSNIYINENKMLYSLLI
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: TPIS_HELPH
Sequence: MTKIAMANFKSAMPIFKSHAYLKELEKTLKPQHFDRVFVFPDFLGLLPNAFLHFTLGAQNAYPRDCGAFTGEITSKHLEELKIHTLLIGHSERRTLLKESPSFLKEKFDFFKDKNFKIVYCIGEELITREKGFKAVKEFLSEQLENIDLNYSNLIVAYEPIWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNIQNAKEILGIDSVDGLLIGSASWELENFKTIISFL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPG1_CAEBR
Sequence: MLPKSVLIVAFLVASSSAQYGVTGMYENLPLESTTVEASGEGSGYNESNDDGFVTGADAVAIDTDCSTKEDGLYAIGGCSPQFLTCSGGIARIMDCPANLIYDQRIIACEYSYNVPECSGVPQDVSSTQAYYPATEETTPAENVTVPAETTVDPYAPVEVATTAAPSEDVPVETTASPYAPVEVETTTAPAEDVTVPEETTVAPYAPVEVYTTAAPANDEPVTRTLLDKTCNGKADGFYSFGQCSDHYIACSNGYTIPMQCPARLSFDEARVICDYTMNVPECQNGSGNYEGSAEETTTEASGELPYSNGYGYEETTTAAADVPSTEGYAPETTAEAWVAPYRLESTTAADVPTTTVGYAPEVIEETTTSEYVEETTTAADVSTTTTVEYVPEVTETTTAPYVEETTTAEYVEETTTAADVPTTTTVAYAPEVTETTTVPYIEETTTVEEATTAADVPTTTGYVPEVIETTTTPYVEETTTAEYVEETSTAADVPTTTTVAYAPEVTETTTVPYIEETTTVEEATTAADVPTTTGYVPEVIETTTTPYVEETTTVEETTTTTVAYAPEVVETTTTPYVEESTTTPYVEETTTALMFHPPQSKATKLPQIHHPASKEHLLSSHAHKTIETVSMDMNLSSSASRDSSSLQSKDDAQLLTKLRSATNRTSTKEATTRTQNMHAHYHRNH
What is the function of this protein?
Required for polar body extrusion during cytokinesis in embryo development.  Affects cortical granule size.  Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2.  Binds chitin (By similarity).
What are the official names of this protein?
Chondroitin proteoglycan 1, Cell junction protein 1, Cytokinesis protein cej-1.
Protein: DNAA_ACAM1
Sequence: METSLETLWSQVLERLQLQLSRPTFETWIKTANAEQLDENRLVIRTPNPFARNWLQKYYVKTIRDVVHEILGHPVEIQIEIAQGDSNATISAPEVASPPPTASPVENTNTSQRQQASLNPKYVFSRYVVGPNNRMAHAACLAVAESPGREFNPLFLCGGVGLGKTHLMQAIGHYRLEISPNSRIFYISTEQFTNDLIAAIRKDGMQKFREHYRAVDVMLVDDIQFIEGKEYTQEEFFHTFNTLHEAGKQVVLASDRPPSQIPRLQERLCSRFSMGLIADIQPPDLETRMAILQKKAEYENIRLPREVIEYIASSYTSNIRELEGALIRAVAYISISGLPMNVENIAPVLNPPTAKISASPESIINAVADTYGISIDDLKGNSRRREISMARQIGMYLMRQHTDLSLPKIGEEFGGKDHTTVMYSCDKVSDLQKKNPELAQSLRQLGDRIKLANQP
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_SYNPW
Sequence: MVLGTSSGAGKSLMTAALCRVLKRRGETPLPFKGQNMSNNAWVDPGGGEMAYSQALQAWAAGREPECAMNPVLLKPQGDSTSEVIHLGRSVGTCRAEHYYRDWFRPGWAAIRQGLHTLENENPEGRLVLEGAGSPVEVNLQARDLTNLRLAQYLRARCLLVADIERGGVFAQIVGTLALLRPVERPLISGLLINRFRGRRELFDEGRRWLEQHTGIPVLGVMPWLDELFPPEDSLDLLERRGRKRGAELEIAVLKLPSLSNFSDLDPLEAEPTVQLRWVAPGEPLGTPDAVVIPGSKQTLRDLGRLHSSGLGSAVQRFARSGGAVFGVCGGMQMLGQELEDPEGLEGQAAAGGNGAMTGLGLLPLRTRFGGEKALRHRQSSVHWPEHQPTLSVEGFELHRGHTHALEPCSNLCEDPSLGWVARCGDQGGIAAGTYLHGIFDNGPWRRRWLNQLRIRRGLELLSEQQPHHSRQRDALLDRLADAFETHVNLEPLL
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: EFG_STRM5
Sequence: MARSTPIERYRNFGIMAHIDAGKTTTSERILFYTGKSHKIGEVHDGAATMDWMEQEQERGITIQSAATTAFWKGMDKSLPEHRFNIIDTPGHVDFTIEVERSLRVLDGAVFVLCAVGGVQPQSETVWRQANRYKVPRIAFVNKMDRTGANFYKVRDQLKAKLGAVAVPMQLPIGAEEGFKGVVDLLKMKAIHWDEASQGMKFEYGDIPADLQEKAEEARTFMIEAAAEANEELMEKYLGGEELAEAEIINALRTRTLATEIVPMYCGSAFKNKGVQAMLDGVIQLLPSPVDVPDVTGTDVDDENLAMSRKSDDKAPFSSLAFKIITDPFVGALTFFRVYSGTLNGGDTVLNSVKGKKERIGRILQMHSNNREEIKEVLAGDIAAAVGLKDTTTGDTLCSIDQPIILERMTFPEPVISMAVEPKTKSDQEKMGLALGRLAQEDPSFRVKTDEESGQTIISGMGELHLDIIVDRLKREFNVEANVGAPQVAYRETITLADVKSDYKHAKQSGGKGQYGHVVIELSPLTAADRADAKLAPAIKDDFLFVNDITGGVIPKEFIPSIEKGLRETITSGPLAGFPVVDVKVKLVFGSYHDVDSSEMAFKLASSMAFKQGFAKAKPVLLEPIMKVEIVTPEDYQGDVMGDVSRRRGVLQGSDTTGDGSASIINAMIPLGEMFGYATALRSQTQGRATFTMEFDHYEPAPNNIAEAVMKKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECOT4_TRYB2
Sequence: MFGSRKASRRRSYRSRSTMGSRVDIDFCKFEEPPSPREGERRCLFVLDPLEHYVESKDRMVELLPGRVETVDGVNTYYINGCTTEEKFPGLDYTCYRVDLRDTYRSRCAVPPEATPEEKFISHRHRKLIPYNSRKPVVVYLPEDAQLHYRIWTGGQEVVAKKAEE
What are the official names of this protein?
Ecotin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: ACS2_ZYGBA
Sequence: MTVKEHKVVHEAQNVEALHAPEHFYKSQPGPSYIKDMKQYKEMYKQSVEDPENFFGEKARELLDWDRPFTRSKYGSLENGDVTWFLNGELNAAYNCVDRHAFANPDKPALIYEADEEADNRMITFSELLRQVSRVAGVLQSWGVKKGDTVAVYLPMIPEAVVAMLAIARLGAIHSVVFAGFSAGSLKDRVVDAGCKVVITCDEGKRGGKTVHTKKIVDEGLNGISLVSHILVFQRTGSEGIPMTAGRDYWWHEETAKQRSYLPPVPCNSEDPLFLLYTSGSTGSPKGVVHSTAGYLLGAAMTTRYVFDIHPEDVLFTAGDVGWITGHTYALYGPLVLGTASIIFESTPAYPDYGRYWRIIQRHKATHFYVAPTALRLIKRVGEAEIPKYDISSLRVLGSVGEPISPELWEWYYEKVGNKNCVICDTMWQTESGSHLIAPQAGAVPTKPGSATVPFFGVDACIIDPVTGIELQGNDVEGVLAVKSSWPSMARSVWQNHHRYVDTYLKPYPGYYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTAEIEASLTNHDNVSESAVVGIADELTGQSVIAFVSLKDGSSRESSAVVAMRRELVLQVRGEIGPFAAPKCVILVKDLPKTRSGKIMRRVLRKVASNEADQLGDLSTMANSEVVPSIIAAVDEQFFAEKKK
What are the official names of this protein?
Acetyl-coenzyme A synthetase 2, Acetate--CoA ligase 2, Acyl-activating enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: 5HT2A_CANLF
Sequence: MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores.  Affects neural activity, perception, cognition and mood.  Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances.  Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
What are the official names of this protein?
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, 5-hydroxytryptamine receptor, Serotonin receptor 2A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Presynapse.
Protein: EFG_HALH5
Sequence: MAREFSLENTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKNNRINIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRVVFVNKMDKTGADFLYSVSTLHDRLQANAHPIQLPIGAEDNFEGIIDLVDMVAYFYEDDLGTRTEAKEIPDEYKEQAQEYHEKLVEAAAELDEELMMKYLEGEELTKDELKAAIRKGTCNVEFYPVLCGSAFKNKGVQLMLDAVLDYLPSPLDVPAIKGHVPDTEEEAVRKPGDDQPFAALAFKVMTDPYVGKLTFFRVYSGTLDSGSYVKNSTKDKRERVGRILQMHANHREEISTVYSGDIAAAVGLKDTSTGDTLCDEKNLVILESMEFPEPVIHLSVEPKSKADQDKMGLALAKLAEEDPTFKTHTDEETGQTIIAGMGELHLDIIVDRLRREFKVEANVGAPQVSYRETIRQAAQVEGKFVRQSGGRGQYGHVWIEFSPNEEGAGFEFVNGIVGGVVPREYIPSVQAGLEEALENGLLAGYPVIDIKAKLFDGSYHDVDSSEMAFKIAASMALKNAKSKCNPVLLEPMMKVEVVVPEEYMGDVMGDITSRRGRVEGMEARGNAQVVKAFVPLAEMFGYATSLRSRTQGRGTYTMFFDHYEEVPKSISEEIIKKNSGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Protein: YQGF_AERS4
Sequence: MSSRSIMGFDYGTKSIGVAIGQELTGTAQPLRAIKANDGVPNWDDIEKLLKEWQPDLLVVGLPLNMDGTEQEITVRARKFGNRLHGRFGKQVEFKDERLTTTDARARLFERGGYKALDKGSVDGVSAQLILEAWMEEQYG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_RICPU
Sequence: MSEIWEDAIKSNAWPFVEAKKILDSLNGQIPEKGYVLFETGYGPSGLPHIGTFGENARMVMVQKAFEQLSDIPTKLICFSDDMDGLRTVPSNIPNPEMVAQYMDMPLTSIPDTFGECESYGHYMNAKLRSFLDKFGFEYAFYSSTNCYKAGMFDEMLIMVLEKYDEIMELMLPTFREERKATYSPFMPICPKTGKVLQVPIEKWDAKAGTVTYKDKAGNYIEVPVTGGHCKLQWKPDFGMRWAALKVDYEMYGKDHLANARLYSEICRILGGKPPVQLCYELFLDENGEKISKSKGNSISIDDWLKYAPVESMALFMYQNPTRAKRLFFDVIPKNVDEYITFNQKYHLEEDRAKRFANPVYHIHHGNVPKIETFGITYSLLLNLTSVCNPSDKSVLWGFISKYEPNATPNTNPYLDHLAEFAIRYYNDFIKAHKSYLSPSEKHKVILQDILDMLSDIADQTEAEAIQKAIYDIGMKAGYENLRDYFKDLYQILLGQNEGPRLGTFIKLYGVQEMKKLVEGQL
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y730_PSEA7
Sequence: MSYVIDRRLNGKNKSTVNRQRFLRRYREHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPVLHHGRGGRQTVVHPGNKEFTAGEHIARPSGGGGGRGGGKASNSGEGMDDFVFQITQEEFLDFMFEDLELPNLVKRHITGTDTFKTIRAGISNDGNPSRINIVRTLRSAHARRIALSGGSRAKLRAALKELERIRREEPDNLGDIQELELEIAKLRARIDRVPFLDTFDLKYNLLVKQPNPTSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYEKIEVVFIRHHTSAREVDEEEFFYSRETGGTIVSSALKMMQEIMAERYPTHEWNIYAAQASDGDNWNDDSPVCRDILLKQIMPFVQYYTYVEITPREHQALWFEYERVREAFEDSFAQQQIVSASDIYPVFRELFQRRLVA
What are the official names of this protein?
UPF0229 protein PSPA7_0730.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: MEFA_STRPY
Sequence: MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIVCPMINEIRKLDLK
What is the function of this protein?
Confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides but not to 16-membered macrolides, lincosamides or analogs of streptogramin B.  May function as an efflux pump to regulate intracellular macrolide levels.
What are the official names of this protein?
Macrolide efflux protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YQJI_ECOLI
Sequence: MSHHHEGCCKHEGQPRHEGCCKGEKSEHEHCGHGHQHEHGQCCGGRHGRGGGRRQRFFGHGELRLVILDILSRDDSHGYELIKAIENLTQGNYTPSPGVIYPTLDFLQEQSLITIREEEGGKKQIALTEQGAQWLEENREQVEMIEERIKARCVGAALRQNPQMKRALDNFKAVLDLRVNQSDISDAQIKKIIAVIDRAAFDITQLD
What is the function of this protein?
Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions.  Also represses its own expression.
What are the official names of this protein?
Transcriptional regulator YqjI.
Protein: RDRP_I66A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQKLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKGMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: DDL_HAMD5
Sequence: MPEKVAVLLGGTSSERQISLQSGHAVVAGLREAGIDARPIDTKNFLVTELKEKGFTKAFIALHGRDGEDGHLQAVLEFLKIPYTGSGVMASALAMDKHRSKMIFQGAGLPVSPYVALNREQIWPNVTQNTSNDLLLNNRISNKLIKNINQLGLPLIVKPSREGSSFGMTKVEHLDQLDDALKKAWHYDEEILVEKWHFGTELTVAILGDTVLPSIRIQVSDIFYDYQAKYVSDKTQYFCPSGLKQEQEKQLATLSMNAYRALGCDGWGRVDVMLDDEGHFYLMEINTAPGMTDHSLFPMAARQAGFSFSELVCKILSLAH
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTA_ACISJ
Sequence: MHAISSAAPAPSVRLPFYRQLYFQVVFAIIIGVLLGHFQPEYGAAMKPFGDAFIKLIKMIIAPVIFLTIVTGIASMSHLSAVGRVFGKAMAYFLTFSTLALVVGLVVANVMQPGTGMHINVAELDQTAVKGYVSKSHEMTLTGFALDIIPKTLISPFVGDNILQVLLVAVLFGVSLAMVGDAGKPILDFLDGLTKPVFKLVNIVMKAAPIGAFGAMAFTIGKFGLGSLVNLAELVLTFYITSAVFVLVVLGAVARACGFSVLKLIRYLKAELLLVLGTSSSESALPSLMEKMEKAGCAKSVVGLVVPTGYSFNLDGTNIYMTLAALFIAQATDTHLTLGHQIALLLVAMLSSKGAAGVTGAGFITLAATLAVVPEVPVAGMALILGVDRFMSECRSLTNFIGNAVATVVVSRWENALDADRLHRVLDGEAEFLPEPERAVEPVVLARHRA
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TX8E_ANEVI
Sequence: MASARTLVLLLIGAVLMCQVSADSELLNEILAAHMEEDMPEKRCIDRYRSNICGSVIRPLDCTRRKSRMGRFARTNCKKLCGFC
What are the official names of this protein?
U-actitoxin-Avd8e, U-AITX-Avd8e, Avtx-5.
What is the protein family that this protein belongs to?
Belongs to the sea anemone 8 toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.