PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_META1
Sequence: MTNDKIRNFAIIAHIDHGKSTLADRILEFTSTVSARESKAQILDSMELEQERGITIKLNAVQIKYKDYIFHLIDTPGHVDFTYEVSRSLAACEGALLLVDATQGIQAQTLANVYLAMEHDLEIIPIINKIDLPSADPERVKAEIENIIGIDASNAILISAKTGANIDKVIEAIIEKVPCPKEADSTKPLEALIFDSYFDNYRGVVILTRIFNGEVKVGDEIYFMQTKKSYFVTELGVKNPNEVKKDKLSAGEVGWISASIRDVKDVSVGDTLTLANNKLTTPLPGYKKLKPVVYTGFYPVDTRDYNDLKDALEKISLSDSSIVWEPETSKALGFGFRIGFLGLLHMDVLQERLEREFNLDIIATAPSVEFVVTLTNGDVQYITNPSLFPDRSTIKSIEEPFIKASIFLSDEYLGAIMELCQQKRGKYIDIEYIDDHRRKLIYELPLNEIIFDFFDLMKSYSKGYASFEYDFIGLRESDLVKVDILLNGEKIDALAMIVHRDFAYNKSRDLTEKLKEVIPRQNFEIPVQAAIGAKIIARETIKSYRKDVTAKLYGGDVTRRQKLLKKQKLGKKRMKSIGTVEVPQEAFLAILKTDTSKKRE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CISY_BACSU
Sequence: MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEEAAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALGENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQPSEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPSAVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGNDRDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMVGWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS
What is the function of this protein?
Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle.  Loss in activity results in sporulation defect.
What are the official names of this protein?
Citrate synthase 1, Citrate synthase I.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: LOLE2_EPIUN
Sequence: MTAASSPHPGVSAEDIEFYQANGYLRLPQEAHGLFDDLAKLQVWVAEISQWGLETGKWRHYYETTNGKHLLWGTEKLMEYHAPMQDLISGEAPLALLKSLTGKDMVVFKDEIGWKLPGGKGAVPHLDRPAYSMFAPEFIEIMIAVDAHTVENGCLQFVPGSHKEAAPISADGRIASAWLEGKEFIPMVLDPGDVLIFNESMAHRLEPNKTDQRRAAVFGTYHFDLSQPDLRDKFYAHRLIHSPPENAWVEKVGAQT
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of loline alkaloids, potent insecticidal agents composed of a pyrrolizidine ring system and an uncommon ether bridge linking carbons 2 and 7 (PubMed:15654104).  Lolines are structurally differentiated by the various modifications of the L-amino group and include norloline, loline, N-methylloline, N-acetylloline, N-acetylnorloline, and N-formylloline (PubMed:15861432, PubMed:25531527).  The first committed step is the condensation of O-acetyl-L-homoserine (derived from L-aspartic acid) and L-proline, probably catalyzed by the gamma-type pyridoxal 5'-phosphate(PLP)-dependent enzyme lolC, to give the diamino diacid, NACPP (PubMed:15861432, PubMed:16755627).  Ensuing cyclization, decarboxylation, and acetylation steps yield 1-exo-acetamidopyrrolizidine (AcAP)(PubMed:24374065).  LolO is required for installation of the ether bridge upon the pathway intermediate, 1-exo-acetamidopyrrolizidine (AcAP) (PubMed:29537853).  In sequential 2-oxoglutarate- and O(2)-consuming steps, lolO removes hydrogens from C2 and C7 of AcAP to form both carbon-oxygen bonds in N-acetylnorloline (NANL), the precursor to all other lolines (PubMed:24374065, PubMed:29537853).  The enzymes lolD, lolE, lolF and lolT have also been proposed to be involved in the ether-bridge installation (PubMed:15654104).  Further processing of the exocyclic moiety of NANL by fungal N-acetamidase (LolN), methyltransferase (LolM), and cytochrome P450 (LolP) enzymes, with occasional involvement of a plant acetyltransferase, generates the other known lolines (PubMed:25531527, PubMed:18655839).  LolN transforms NANL to norlonine which is monomethylated and dimethylated to respectively lonine and N-methyllonine (NML) by lolM (PubMed:25531527).  LolP catalyzes hydroxylation of the methyl group in N-methylloline (NML) and further oxygenation to N-formylloline (NFL) (PubMed:18655839).  A plant acetyltransferase is responsible for the acetylation of loline to form N-acetylloline (NAL) (PubMed:25531527).  LolA might interact with aspartate kinase to prevent feedback inhibition of its activity by these end products and thereby promote production of L-homoserine from L-aspartate (PubMed:15654104).
What are the official names of this protein?
Dioxygenase lolE2, Loline biosynthesis cluster 2 protein E.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: CNTF_RAT
Sequence: MAFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNINLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEADGMPATVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHQMGISALESHYGAKDKQM
What is the function of this protein?
CNTF is a survival factor for various neuronal cell types.  Seems to prevent the degeneration of motor axons after axotomy.
What are the official names of this protein?
Ciliary neurotrophic factor, CNTF.
What is the protein family that this protein belongs to?
Belongs to the CNTF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NKG2D_HUMAN
Sequence: MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
What is the function of this protein?
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells.  Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity.  Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.  Stimulates perforin-mediated elimination of ligand-expressing tumor cells.  Signaling involves calcium influx, culminating in the expression of TNF-alpha.  Participates in NK cell-mediated bone marrow graft rejection.  May play a regulatory role in differentiation and survival of NK cells.  Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
What are the official names of this protein?
NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
Protein: GUAA_AZOSB
Sequence: MSHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVYEAVDWRAPQVVFELGVPVLGICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQGIEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCPVAAMADEERGFYGVQFHPEVTHTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDPEQKRKIIGREFVEVFQAEAAKLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGLPETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPGPGLGVRILGEVKKEFADLLRRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAHWAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PTH_BRUO2
Sequence: MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASP2_VITVI
Sequence: MKSTGEATAINIGETKSASATTVATTKAIQHPKAGLKRGLAIFDFILRLSAIGAALAATTTMGTTDQTLPFFTQFFQFQASYDDLPAFSFFVIANAIASGYLFLSLPFSIVCIVRPHAMGARLLLVICDTVMVALTIAAAAAAAAIVYLAHNGNSNANWVAICQQFDDFCQSVSGAVVASFIAAVLFMLMIVLSAFSLRKH
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 2, VvCASP2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: PYRG_XYLFT
Sequence: MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVRTRLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITDEIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVRIERGAERTMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDIDVLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYVDYQDAYKSVGEALKHGGLRQRTKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFEGKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGANSTENDRQSSHPVIALITEWRTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRTQLEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASRARKAGGKLLREVCV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PYRB_BACHK
Sequence: MSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDVRHSRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVEREKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: PRI2_DROME
Sequence: MEFGLKKRARHEVKVEVASLETKYPHNVMLYHYPPTEDVHIDEFEELALERLRLLRVLDRASTRNLRVLSDEWKEIVSADLTREGLRSYLRLCSTGGSAKHEADIQTRRRDYLSHFILRLAYCRSEDLARWFVAREMELFRYKFAALSSFEVKQFLEANGFEIHPLTEAQKDEVKDGLYESTVGQSVAKIELLDFYKVPFTQVLDLVRGRRCFLKAGYAYVNTHDLVSLVGTKQQDEIEQGLQAAKTMVEDVEADERISRTLKALHNSYTGRDYTVCRDAAVPIESLDQLSKTSMPLCMRMCHEHIRANHHIKHSGRMQYGLFLKGIGVALEDSLRFWREEFTKKMDADKFTRSYEYNIYHNYGKKGSMVNYTPYSCAKIIKDVAGPGDCHGCPYKNMDQGSLKTKLSSYGLSASAIDEVMFFVSRGHYQIGCGKYFQLTHNSPVEPSINHPNNYFEESQIAMGNRQKRANGSAPPKARIRPDIKGHGDRSMLMGDDDDELWRIAETQERIMQSQKDISEAFNDDLDLTQIDY
What is the function of this protein?
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6773966, PubMed:6409898, PubMed:6403945).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:6812052).  These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).  In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:6812052).  Stabilizes and modulates the activity of the catalytic subunit (By similarity).
What are the official names of this protein?
DNA primase large subunit, DNA polymerase subunit beta, Suppressor of fat facets 240.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: PR2E2_ORYSJ
Sequence: MAAPTAAALSTLSTASVTSGKRFITSSFSLSFSSRPLATGVRAAGARAARRSAASASTVVATIAVGDKLPDATLSYFDPADGELKTVTVAELTAGRKAVLFAVPGAFTPTCSQKHLPGFIEKAGELHAKGVDAIACVSVNDAFVMRAWKESLGLGDADVLLLSDGNLELTRALGVEMDLSDKPMGLGVRSRRYALLADDGVVKVLNLEEGGAFTTSSAEEMLKAL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides (By similarity).  May be involved in chloroplast redox homeostasis (By similarity).
What are the official names of this protein?
Peroxiredoxin-2E-2, chloroplastic, Glutaredoxin-dependent peroxiredoxin, Peroxiredoxin IIE-2, Thioredoxin peroxidase 2E-2.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx5 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: PTH_YERP3
Sequence: MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAERHNQSLKEESKFFGYTARLNLAGQDIRLLVPATFMNLSGKAVAAMASFYRILPEEILVAHDELDILPGMAKLKLGGGNGGHNGLKDIQNKLGNNPNFYRLRIGIGHPGDKSKVTGFVLGKPPASEQTLIDNAIDESIRCTEVLLNEGMTKAMNRLHAFKASA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNL3L_HUMAN
Sequence: MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
What is the function of this protein?
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML.  Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation.  Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase.  Required for cell proliferation.  By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition.  Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation.  By acting on MDM2, may affect TP53 activity.  Required for normal processing of ribosomal pre-rRNA.  Binds GTP.
What are the official names of this protein?
Guanine nucleotide-binding protein-like 3-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Protein: Y3905_BRADU
Sequence: MLTCIENVLSKDDVADFRRIMDASAWEDGRSTAGSQSAMVKRNEQLPPDSEVARKLGNRIISALTSNPRFIAAAIPLQIFPPLFNRYAATSGHHFGLHVDNAIRGDRLTGLRIRTDLSVTLFLAEPDEYDGGELVIEDTYGSHEVKLPAGDCVLYPSTSLHLVTPVTRGARVASFFWLQSMIRDDQARSMIFDLDTAIQALVERLGRDDPETVKLTGIYHNLIRYWAEV
What are the official names of this protein?
PKHD-type hydroxylase blr3905.
Protein: RNC_PEDPA
Sequence: MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVSEYLFKRYPEMPQGKLTRLRAAMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLCDIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHIIDHKSELQELLQKNGDVEIDYELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH2_NEUCR
Sequence: MAGELNAAPVLSTPEDHLFEYAVVPTDDQTKAKSDDELRDIYEITRTAKEVGEGGWRRIGLQFPDHMLCDAPRVVQLLEAELASLPQPTVPTSTADLQSTATACPEPSTTNNGQCGRNVQQNGTGCGCGKQAPAPVESQPKARRVYVLADTSYSACCVDEIAAEHVNADVVVHYGRSCLSPTSRLPVIYVFTKHILDRDAALVKFEKEYPDKEAKVVLMADVTYQVHVPSLLSELQSGGYVNLLATEIVHNPMGRIPNRKVVDAQGKEVEISHGSETSTGLDLRDYSIFHISQPPTALLLALCSRVKNLYIFQTSSDSSSLYSAQRLLGRRYARLLSLTTAGIIGILVNTLSVSNYLSSIDSIRKQIAAAGKKSYTMVVGKLNPAKLANFAEIDGWVVVGCWESSLIEDDAGFYKPVITPFELELALASDDERVWTGEWWGGIEAVKPPIDEKPGEKKSEENENNEAQDTAGAEQASGDGELDSEEESAPPEFDWRTGKLVSHSRPMRMAASKPKSAKKEDSSDKPDAPPRSSALTLRSKAQELASVNGVVSPGAEYLRTQRTWVGLGTDFDEEASMTIEEGRGGVARGYTVGGEGEKHLMS
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase, predominantly cbr-1 (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph-1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSG1_WHEAT
Sequence: MAALVTSQLATSGTVLSVTDRFRRPGFQGLRPRNPADAALGMRTVGASAAPKQSRKPHRFDRRCLSMVVRATGSGGMNLVFVGAEMAPWSKTGGLGDVLGGLPAAMAANGHRVMVISPRYDQYKDAWDTSVISEIKVVDRYERVRYFHCYKRGVDRVFVDHPCFLEKVRGKTKEKIYGPDAGTDYEDNQQRFSLLCQAALEVPRILDLNNNPHFSGPYAMLCRAVPRRAGEDVVFVCNDWHTGLLACYLKSNYQSNGIYRTAKVAFCIHNISYQGRFSFDDFAQLNLPDRFKSSFDFIDGYDKPVEGRKINWMKAGILQADKVLTVSPYYAEELISGEARGCELDNIMRLTGITGIVNGMDVSEWDPIKDKFLTVNYDVTTALEGKALNKEALQAEVGLPVDRKVPLVAFIGRLEEQKGPDVMIAAIPEIVKEEDVQIVLLGTGKKKFERLLKSVEEKFPTKVRAVVRFNAPLAHQMMAGADVLAVTSRFEPCGLIQLQGMRYGTPCACASTGGLVDTIVEGKTGFHMGRLSVDCNVVEPADVKKVVTTLKRAVKVVGTPAYHEMVKNCMIQDLSWKGPAKNWEDVLLELGVEGSEPGIVGEEIAPLALENVAAP
What are the official names of this protein?
Granule-bound starch synthase 1, chloroplastic/amyloplastic, Granule-bound starch synthase I, GBSS-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Amyloplast or chloroplast, granule-bound.
Protein: SPRTL_BACAN
Sequence: MDEQEIQRLVEEVSLQYFGMPFLHKAMFNSRLRTTGGRYLLNTHNIELNYRYYEMYGKEELVGIVKHELCHYHLHITGRGYKHRDKDFRELLKAVDAPRFCKRMVNAEKEKRVYVYECMECLLQYVRRRQINTKRYVCGKCKGKLNLIKKTS
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_EXIS2
Sequence: MFVDQVNIYVKAGDGGRGQVAFRREKYVPDGGPAGGDGGHGAHVVLEVDEGLRTLMDFRYKRHFKAVQGENGMSKGMHGRKAEHLVVKVPPGTVVYDDDTDAVIADLVHHGQQAIVAKGGRGGRGNSRFATPANPAPEHAENGEPGEEKYLKLELKMLADVGLVGFPSVGKSTMLSIVSAARPKIGAYHFTTITPNIGVVETEDSRSFVMADLPGLIEGASEGVGLGHQFLRHVERTKVIVHVIDMSGMEGRDPIDDYNIINKELADYNLRLTERPQVVVANKMDMPDAEANLEAFKEAFPDLEVFAISAATRQGLRDLLFRIADLVDATPEFGLEELEEKTATPRVVYGYEAPEAGFTVSKDEDDCFVIKGPRIEKLFTMTNFMREESIKRFARTLRQMGVDEELRKMGAIDGDVVRIRDFEFEFIESSF
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARPC2_CAEEL
Sequence: MIILEQNNRIIVELLEQKFANAKEGGKPESVNVTFADFDGVLYKLSNPDGDRTKIILSISLKFYTELQQHGADDLLRRVYGGHMRSTPEQGFNVTLEYNLADLPADTTDLVQAASALKRNCFASVFEKYFEFQEAGQEGHKRAVINYRDDETMYIEAKADRVTVIFSTVFKDADDVIIGKVFLQEFREGRKASQTAPAVLYSLGEPPLELKDLPEARVGDNVGYITFVLFPRHTNKKTKDNTIDLIHSFRDYLHYHIKCSKVYLHTRMRAKTTDFLKVLNRARPEVKGEKKTFHGRTFQTQ
What is the function of this protein?
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the mother actin filament (By similarity).  Plays a role in time-dependent memory loss and the retention of conditioned behavior over time (PubMed:24630719).
What are the official names of this protein?
Probable actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RS17_BURPS
Sequence: MNDSVKTSLKRTLVGKVVSNKMDKTVTVLVEHRVKHPIYGKYVVRSKKYHAHDEANTYNEGDLVEIQETRPVSKTKAWAVSRLVEAARVI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PG76K_BISBO
Sequence: SPEFTV
What are the official names of this protein?
Unknown placental glycoprotein 76K.