PharMolix/UniProtQA huggingface dataset:
Protein: NET1A_ARATH
Sequence: MATVLHSESRRLYSWWWDSHIPKNSKWIQQNLSDMDSKVKAMIKLIEEDADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHATVELCHAHKTMAEAFPNQVPFDMIEDSASSSCSEPRTPEKMPPGIQPFYDSDSATSKRGLSQLTEYLGNSETEVESLKRTLVELGAEKEALNLQYQLSLNKFSRLEKDLEVAQKDVSGLDERASKAEIETKILAEALAKLEAERDAALLRYNESMQKITELEESFSHAQEDVKGLTNRATKAETEVENLKQAHSRLHSEKEAGLAEYNRCLEMISNLEKKVRDAEENAQNFSNQSAKAEDEIKALRHELVKVNEVKDGLRLRYQQCLETISKLEREVSHAQDNAKRLSSEVLAGAAKLKTVEDQCTLLESSNETLKLEADGLTHKLAAKDQEIFQKQNELEKFQSLIEDEHSRYLEIEVSLKTLQSLYSQSQEEQKVITSELQSRIGMLRDLETRNLKLEGDISSVKEENQNLSELNDSSMIFLETQKCEISSLKEIKEKLEEEVARHINQSSAFQEEIRRLKDEIDSLNKRYQAIMEQVNLAGLDPKSLACSVRKLQDENSKLTELCNHQSDDKDALTEKLRELDNILRKNVCLEKLLLESNTKLDGSREKTKDLQERCESLRGEKYEFIAERANLLSQLQIMTENMQKLLEKNSLLETSLSGANIELQCVKEKSKCFEEFFQLLKNDKAELIKERESLISQLNAVKEKLGVLEKKFTELEGKYADLQREKQFKNLQVEELRVSLATEKQERASYERSTDTRLADLQNNVSFLREECRSRKKEFEEELDRAVNAQVEIFILQKFIEDLEQKNFSLLIECQKYAEASSFSEKLIAELESENLEQQMEAEFLVHEIDNFRGAICQVFKALQVEADCKTADQKIAKERIPVSRVLGEINELKCSLSSAEYETQRLVIENSVLLSLLGQFQSDGMKLESEKRDVEKDLETIVHHYGMLKKDRLELLEMNRQLKSELIDREQRELELKAELQTEHLKFENLHESYMALHQDYSDALGKNKSLHLKFSELKGEICILEEENGAILEEAIALNNVSVVYQSLGSEKAEQAEAFAKNLNSLQNINSGLKQKVETLEEILKGKEVDSQELNSKLEKLQESLEEANELNDLLEHQILVKEETLRQKAIELLEAEEMLKATHNANAELCEAVEELRKDCKESRKLKGNLEKRNSELCDLAGRQDEEIKILSNLKENLESEVKLLHKEIQEHRVREEFLSSELQEKSNEFGLWDAEATSFYFDLQISAVREVLLENKVQELTGVCENLKDEAVTKTTEINQIKETVGFLEFEVSELKTQLSAYDPVVASLAEDVRSLEQNALSLMKLPVPAGRRREGVQNDEHQEAAVSQEPVGHCSTNLDNGIVLLQDMKTRIKTIKQAVAEEKKRRGKLRRRSSSHRSKDRKLFEEIELEDQFSGEIRQPRSPAMTESKNGSLMKDIPLDQVADTTSYGRSRRTSRGSSDQMLELWEEAAEPESSIKFLINNKNSKKPLIPRLHRRSRNPSVESQSEKMVGVVDKLELSRSTEDNAKILERLLSDSRRLASLRISLRDLKSKLEINEKPGKFTNPDFARVRKQMKEMEEAIFQLANTNEILSNEIEETGDVRDIYRKVVMEKSRIGSEKIEQMQQEMQNIERTVLKLEEGATKSKGRRKFSESRTVILLRDIIHKGGKRTARKKKNRFCGCMRSSGNEE
What is the function of this protein?
Plant-specific actin binding protein.  Associates with F-actin at the plasma membrane and plasmodesmata.  May be part of a membrane-cytoskeletal adapter complex.
What are the official names of this protein?
Protein NETWORKED 1A.
What is the protein family that this protein belongs to?
Belongs to the NET family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane. Cell junction, plasmodesma. Note=Localizes to the cell cortex and shows polar enrichment at the apical and basal cell boundaries.
Protein: Y1157_CHLT3
Sequence: MQLGDMSAMLKQVQQMSEKMQEAQKQLESMTAIGESGGGLVKAMANGKHEIISIQIDKDVLDDVDMLQDLIVAAVNQALTEATKMAQEEMSKVTGGMMGDMNFLKNLNMGG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Ctha_1157.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YD206_YEAST
Sequence: MHKPLRWLITIAFYVSNVILIGYSLSSNGSISEFYLHSVVLIECFSLLGVVTSDCLTPSLSYISSNIFHISDRVSGMTLLALGNALPDITSTYQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGCVATIQFQHDKSIETYTEESFDQNLSYDRSNYILDVGIFTFMLLVSGTFLADGRLYFWECIVMVLTYCCCAVYLIKSYKYPCEINDALEREVEIKKTVLANNHITVPNRFTLTTTSDITSTDDGIRYVRPLGDTQIDEDNAISLDPTRLPSKSLDNISRFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDLLNIWEKQNLFNNTVKSLSLPSDDTHLFTKASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNALDTAISAPQNEYQTYYNEPTSLFLTVPQKKTSKKSLSCDRIPNLVRSNNIILNDEATRTQESTNALNSISDVIDNSLLQYERDDIILDRTLSLCSTKSRTAWHSFQLYNYLTDVSLEIGFFEFLSLLVTTPVSIILYLSIPSEISQTDHDLPLSYLQNIQLIASPIILNQLITNNFSFWLLILSLVIAILLYFKTRTIPNKFNSDIIFTVAFLLSLACLSKAVHIIVVTLTHWINVFNISETILGLTIFTWGNSIGDLVSNITFVKIGVLEIAIGACFGSPLLYFLFGVGFDGIMIMLGDKTGKIVSGRDSNILMHHIDFKVDKNLINTGVGILIAFLIFTVLIPLNDWKIDKKISIALLTLYIVVTCISVFLEVHQV
What is the function of this protein?
Putative cation exchanger.
What are the official names of this protein?
Putative cation exchanger YDL206W.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL20_UREP2
Sequence: MRVKGGSVTRQRRKRWLEKAEGSWGTRNTSYRIARQTVIRAAEYAYRDRRNKKRDFRKLWISRINAAVRELGYTYSQFMNALVKANVVTKDGQGLNRKMLSELAINNPEAFNQLVDKVMK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ACKA_THEVB
Sequence: MITVLVLNAGSSSLKASLYRLAPEIGATAVRPPAPLWQGLLDWGQNPTVARLKVTTANQHYEANLTHPEGGIAGLRDWLKSLLDTLTSGQTKLLENLAEITIIGHRVVHGGSRYQAPVRVDAQVKAAISELSEYAPLHNPANLLGMELMADICPQTPQVAVFDTAFHAQLPAVARTYAIPYELTTAGIQRYGFHGISHQYVSERAATLLQRPLAELHLITCHLGNGCSLTAVKGGVSVETTMGFTPTAGVMMGTRCGDIDPGILLYLLRRGWTVAELDRLVNRQSGLLGVSGVSNDLRQILAAIDQGNPQAQLAYDCFIYSLQRGIASLLPALGRLDGLVFTAGIGENAPGVRRDICRGLGWLGIELDSTANEKGQGDRNIALPTAPVSVLVVQTQEDWAIARACGQLLSLPISS
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNT1_SODGM
Sequence: MERGAGLWLGLLAVFFVLTYLVPLEGRLLWQPDETRYAEISREMLASGDWMVPHLLGLRYFEKPLAGYWMNNIGQWLFGSTNFAVRFASVFSTGLSALLVFTVSWTVGRQLRQSLLAALIFLSLLLVFGVGTYSVLDPMIALWLNAAMAAHVFALRADRRTTRGVAWLLLGLACGLGFMTKGFLALVVPAIAVLPVALYYRQLKATLGYGALAALLAVLVNLPWALALSRLEPDFWHYFFWVEHIQRFAAENAQHRAPFWFYLPVLALGSLPWLGLLPGAMAAGWRARRVQPERFLLLCWVVMPLLFFSVAKGKLLTYILPCMAPLALLLAAYGRECADKLRSKVFDANAGINTAFALCAIVALLLAGSGLLPWARIYSVGEWPRIVIGTLVFAGWLCFAAVSRRSQGDRWALAAFCPLLLSLLVGQIIPQRIIDGNQPQEFIRRYETTLNQSRYVLSNHVGVATALAWELERNDVLMYDDKGELAYGLEYADVQGRHLSRDDFPHWLAKERLKGDVALLLLLDRRQDLPPGLPKADKVHRNHRIALLHYQQLPCCEQ
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1, 4-amino-4-deoxy-L-arabinose lipid A transferase 1, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAPZA_DROME
Sequence: MEQTPITDAEKVRIVSDFILHAPPGEFNEVFNDVRELLKNDTLLKDGASHAFAQYNKDQLTPVRIEGTDHNAIISEHNDLGNGRFYDPRTKQAFKYDHLRKEASDYQDVEADATAEPWRAALDLETLAYTASHYRHGVSSVFGKAQGNQITLTICIEDHQFQPKNYWNGRWRSQWHVTFQAGSGTAELKGVLKVQVHYYEDGNVQLVSSKECRESVVVSNEQQVAKEVIRLIEDAENEYQLAISENYQTMSDTTFKAMRRQLPITRTKIDWSKIVSYSIGKELKTQ
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: SNKY_DROME
Sequence: MLSLLTRPFLPIFCFLYGPQSEGSTRIQCLRRFVTFLLGLVLGFLLWKLAALNFTLGRLFVNGATDLYVFIIFVLVTGTIFMLSLPVRAVILLIFVALVGKSGRTYLRAVAFAFIISGPIANLVENAGEVARVFVCTTVLTYNLSKTRFDLMAKPFTNTLKHMRGDVEEIRHTFYELQEVLVDLKYAVENSDIEDEKYGDKNTKPIYERWGRETSRMNVSEIGNGGKELPTPAAVQERFQRNMRNRCKHQLRSGHRACLEVFRNGYRKCTTNFPSMIAKAICWPYRVDIICELDLFGNPDKICDPSAVVPQNFGETYVELLKAEKKLFDNSSQIVVNYEIKDEQFAKSQLKSAERTGQAFKEDFERQKRIFNKVMGILQKILCLFMLRMVYVSINYYVKYLNDVEFDNFYITKYFKHVDQRRKEQRIDAILPLRTYEKSKYIDVDHIFSRTHHESTTVCFNLLQFLLELVTAGLFILIDHLVVELLQIVRKRSKIVYQQDGEHEVRFNISGVGQMARLLRTTMHNFNIHEKVSTSLSNKECLPNAHVLPKKMYYQLILLYLIIIVLIYQSTTFLRMRRVICSFFYYKREKQRILFLYNRILRNRLRSLEFLIHDAEDNLATHRIQQQVNVFLWLRFSCPVAFGWIRHFKFAKRTCMICRGLEDSTFTVCGNCGLPYCDDCAEDLNSVCFQCGVVLTRGAEGSESSVEVYTYRKEK
What is the function of this protein?
Component of the sperm acrosome membrane (PubMed:17092953).  Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization (PubMed:9630751, PubMed:17092953).
What are the official names of this protein?
Protein sneaky.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Has diffuse cytoplasmic expression in primary spermatocytes. In post-meiotic spermatids, detected in clusters of vesicle-like structures adjacent to the nucleus. In late spermatids, a single vesicle-like spot is found near the nucleus, which probably corresponds to the acroblast. In mature sperm, localizes to the apical tip of the sperm head (acrosome).
Protein: XYN2_GEOSE
Sequence: MCSSIPSLREVFANDFRIGAAVNPVTLEAQQSLLIRHVNSLTAENHMKFEHLQPEEGRFTFDIAIKSSTSPFSSHGVRGHTLVWHNQTPSWVFQDSQGHFVGRDVLLERMKSHISTVVQRYKGKVYCWDVINEAVADEGSEWLRSSTWRQIIGDDFIQQAFLYAHEADPEALLFYNDYNECFPEKREKIYTLVKSLRDKGIPIHGIGMQAHWSLNRPTLDEIRAAIERYASLGVILHITELDISMFEFDDHRKDLAAPTNEMVERQAERYEQIFSLFKEYRDVIQNVTFWGIADDHTWLDHFPVQGRKNWPLLFDEQHNPKPAFWRVVNI
What are the official names of this protein?
Endo-1,4-beta-xylanase, Xylanase, 1,4-beta-D-xylan xylanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family. Cytoplasmic xylanase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_LEPBA
Sequence: MMNIILIGARGAGKSKVSRSLSKQSEIPVVSTDSVAVYETGGIPIPKFVENNGWKAFRELEYSILQKLQNANGIILDCGGGILFDLDESGNEVLSERKLDLLRKIGRIVYLERGIEELVEKVKGDKTRPDLSKITTYRSILEKRLPVYQEAAHFKLNLTKLSKEEAAEKILDWIGIKSKSI
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR24_CHICK
Sequence: MDENLLATAATNGVVVTWNLGKPSRNKQDQLFTEHKRTVNKVCFHPTEVYMLLSGSQDGYMKCFDLRKKDSVSTFSGQSESVRDVQFSIRDYFTFAATFENGNVQLWDIRRPDRYERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMNTTRAKEIYCVQTIASVARVKWRPECKHHIATCSMMVDHNIYVWDVRRPFIPSAMFEEHKDVTTGIVWRHLHDPYFLLSGSKDSTLYQHIFKDASQPIDRANPEGLCYSLYGDLAFAAKESLISSDSNRKPYIGDRRHPIFFKRKLDPTEQFEYISSSSALSVFETDVESGSMDWFVHTAKQYALAGRPLAELCDHNAKVAKGLDRNQVAQTWTMLRIIYSSLGTVSSTNLNHSMGKGSTTLPLMNSFNLKDIPSGLGSESRLDRSKGESRTENILMDSSSTLINNEDNEETEGSDVPADYLLGDVEADEDDLYMMDHENPHAEEQEYSLPQEAFPLRHEIVDNPSALDHLQDKADSPHVSGNEAETVSLTPVESFSLISISHSLYENRLPSDFFNPIVRDTLLFYAEQGDVQTAVSVLIVLGDRIRKEIDEQTQEHWYTSYIDLLQRFQLWNISNEVIKLSTCRAINCLNQASTTLHINCSNCKRPMSNRGWICDRCRQCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLETSSHCPAGCGHLCEYT
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
GATOR complex protein WDR24.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR24 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: CX5E_CONTE
Sequence: PCCSKLHDNSCCGL
What are the official names of this protein?
Conotoxin tx5e.
What are the subcellular locations of this protein?
Secreted.
Protein: IHFA_NEIGO
Sequence: MTLTKAELADILVDKVSNVTKNSAKEIVELFFEEIRSTLASGEEIKISGFGNFQLRDKPQRPGRNPKTGEEVPITARRVVTFHASQKLKGMVEHYY
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: Y294_NOCFA
Sequence: MQPGGQFDMQQLLAQAQQMQEAVMQAQAEIAATEVEGQAGGGLVKATIKATGEVQALTIDPKVVDPEDVEGLQDLVIGAINDAMARAQQLAAERLGPLAGGGSMPGLPGF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein NFA_2940.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MNMA_LEGPL
Sequence: MKAKVIVGMSGGVDSSVAAWLLKEQGYQVEGLFMKNWEQDDHNDYCPAAKDLADAQAVCNQLRIPLHTVNFSKEYWDRVFAYFLSEYEKGRTPNPDVLCNKEIKFNAFLNYALTLGADYIATGHYAKNTIEGSIGYLFKAKDREKDQTYFLHAVEPEALSKTIFPIGDFTKPQIREFAKQLGLVTHAKKDSTGICFIGEKRFKTFLNEFILAKPGDIKSTGGKTLGQHDGLMFYTLGQRQGLGIGGLQNSTDEPWYVVDKDIASNTLYVAQGSQHPMLYSQGLICGPIHWLADYENHLPLTCFAKTRYRQTDQACMISPPDNNQHYVMFSNPQRAITPGQFIVFYEKNQCLGGATIEQIIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_CAMHC
Sequence: MKQTITEKIFSDHVGAQVYAGEIVESKIDMVIGNDITTPISIRQFEKSGAAHLANPDGFAIVMDHYIPTKDIASANQAKISREFAYKHNLKNFFDEKDIGIEHALIPEKGLVVSGDVIIGADSHTCTHGALGAFSTGMGSTDIAYAMITGKNWFKVPKSIKVVLKGRLGEHIYGKDLILKLISMIGVDGALYKALEFCGDIQNIDMDSRFSMCNMAIEAGAKSGIIAADEITKQFFKDKNLRAEPKYFYSDEDAFYERTVEIDMSALEPMVAYPFLPSNGKTITQAVADELKIDQAFIGSCTNGRLSDLRIAAEILKGKKVAKKTRLIITPATQKIYKAAEHEGLIDIFIDAGAVVSNPTCGACLGGYMGILGANERCVSTTNRNFVGRMGDRTSEVYLANSAVVAASAITGKITDPRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: WRK45_ARATH
Sequence: MEDRRCDVLFPCSSSVDPRLTEFHGVDNSAQPTTSSEEKPRSKKKKKEREARYAFQTRSQVDILDDGYRWRKYGQKAVKNNPFPRSYYKCTEEGCRVKKQVQRQWGDEGVVVTTYQGVHTHAVDKPSDNFHHILTQMHIFPPFCLKE
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
What are the official names of this protein?
Probable WRKY transcription factor 45, AT.I.24-4, WRKY DNA-binding protein 45.
What is the protein family that this protein belongs to?
Belongs to the WRKY group I family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALCB_HUMAN
Sequence: MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA
What is the function of this protein?
CGRP induces vasodilation.  It dilates a variety of vessels including the coronary, cerebral and systemic vasculature.  Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
What are the official names of this protein?
Calcitonin gene-related peptide 2, Beta-type CGRP, Beta-CGRP, Calcitonin gene-related peptide II, CGRP-II.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KCC2D_PIG
Sequence: MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPSCIPNGKENFSGSTSLWQNI
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport.  Targets also transcription factors and signaling molecules to regulate heart function.  In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure.  Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'.  In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program.  Is essential for left ventricular remodeling responses to myocardial infarction.  In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC.  Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2.  In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1. 5/SCN5A and the K+ channel Kv4. 3/KCND3, which contribute to arrhythmogenesis in heart failure.  Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis.  May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.  In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL1_RUTMC
Sequence: MAELTKKQKDILVKVESNKCYSINDALNLLKECATAKFDESIDMSINLGIDAKKSDQNVRGAIVLPNGTGKTVCVAVFTQGDNIAKAQDAGADVVGMEDLMKSMQDGDLNYDVVIASPDAMGVVGRLGQVLGPRGLMPNPKVGTVTSDVATAVNNAKTGQVRYRADKAGIVHACVGRVSFNVSALTQNINVLMEALKKIKPSSAKGVYFKKLSISSTMGPGLSVDLASLDI
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: DP2L_HALSA
Sequence: MRPTDETYFETLETGLDDAFEVAEAARERGEDPTPNVEIPVAKDMADRVENILGIDGVAERVRDLDGEMSREEAALELVADFVDGRVGDYDTDAGKIEGAVRTAVALLTEGVVAAPIEGIDRVEVNDNDDGTQYVAVYYAGPIRSAGGTAQALSVLVADYARAMLGIDAFKPRDDEIERYAEEVDLYDSETGLQYSPKDAETTFITEHCPVMLDGEATGNEEVDGFRDLERIDTNSPRGGMCLVLAEGIALKAPKIQRYTRNLDEVAWPWLQDLIDGTIGADDADEDTPDAGSDSDATDEGDAPSASTDAEEPPRAAPSDKFLRDLIAGRPVFGHPSKNGGFRLRYGRARNHGNATAGVHPATMHLLDDFLATGTQIKTERPGKAAGIVPVDSIEGPTVKLANGDVRHINDPADALDVRNGVAEILDVGEYLVNYGEFVENNHELAPASYAPEWWIQDLDAAGADVQALRDSPYVDLTAPTADQAMAWATDYDAPLHPAYTYLWHDIDVEQFRALADAVADAHTDASDDDDRGVLVLDHTTTVRETLEALLVTHHQGDDTIRVDDWLPLARSLGVTESLDREWETLSEAAAEWPNAVRAVNEVAPFSVQERAPTRIGNRMGRPEKSESRDLSPAVHTLFPIGDAGGSQRDVADAARYAPDMSDTPGEIPVRVGDRVCPSCDEHTYESRCPDCGDWTDPHYECRDCGAVATPDESGRVECPNCGRDLDNVTTQVIDINDEYHGALRAVGERENAFDQLKGVKGLLSAEKTPEPMAKGVLRAKHDVTAFKDGTVRYDMTDLPVTAVTPAELDVTAGQFRELGYNQDIHGDPLEHDDQLVELRVQDVVLSDGAADHMLKTADFVDDLLTQYYGLDAFYDLDDRDDLVGELVFGMAPHTSAAVVGRVAGFTSASVGYAHPYFHAAKRRNCFHPETNVWFRDESGEWHHDPIETLVEARLDPDTADEDDFGALVQALDGDVFVPSVTEDGEETLQRVEAVSKHPAPDHLLAVETKRGRELTVTPDHSMRRWTGDGIERVDARELTAGDALPAPTQVPGDGETATSELRSESLDGTHPQRRFGDGGSVRTDEVVSVEPVRSSVDHTYSLTVAETNTLVANGLFTGQCDGDEDCVMLLMDGLINFSKSYLPDKRGGRMDAPLVMSSRIDPAEIDDEAHNIDIDREYPREFYEATRELADPEDVADLITLAESTVGTDEEYTGFGHTHATSNIHLGPSLSAYKTLGSMMDKMDAQLELARKLRSVAETDVAERVIEYHFLPDLIGNLRAFSRQETRCLDCGEKYRRMPLSGDCRECGGRVNLTVHEGSVNKYMDTAMRVATEYDCREYTKQRLEIMDRRLESVFEDDTNKQSGISDFM
What is the function of this protein?
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.  Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase II large subunit, Pol II, Exodeoxyribonuclease large subunit.
What is the protein family that this protein belongs to?
Belongs to the archaeal DNA polymerase II family.
Protein: RS3_METPP
Sequence: MGQKIHPVGFRLPVTRNWSSRWYASNRNFATMLAEDLKVREYLKAKLKSAAVSRILIERPAKNARITIYSARPGVVIGKKGEDIENLKAELTRRLGVPVAVNIEEVRKPEIDAQLIADSITQQLEKRIMFRRAMKRAMQNAMRLGAQGIKIMSAGRLNGIEIARTEWYREGRVPLHTLRADIDYGFSEAKTTYGIIGVKVWVYRGDRLANGEAPVIKTDEREDDRRNRRGPRSDRPAGDRRPPSRDGARPGPRGPRADAGAAAPTDKPADGAAPAAADGPKAAVKRVRKAVAPGDAKGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: FEN1_LEIBR
Sequence: MGILGLSKLLYDKSPNAIRERELKSFFGRRIAIDASMSIYQFIIAMKGFQDGQGMELTNEQGDVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPKLKADELETRRQKAAEAEREFEKAKDAGDDEMMEKMSKRTVRVSREQIEESKKLLQLMGVPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTVMLRHLNISDAKKRPIAEIHLDEVLQATGLSMDQFVDLCILLGCDYVPKVPGIGPQRAWEGIQRYGNIESFLESLDAAKHMVPPDFCYREARAFFLNPEVTRAEEIDIRFSEPDEAGLIQFLVKEKLFNPDRVNKGIARLRAALTKKTQGRLDNFFTIVKAPPQAAAPRAPLAGRKRSHDGKCVHVSGTLQKATGGHKKAVRK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.