PharMolix/UniProtQA huggingface dataset:
Protein: PPIB_ORPSP
Sequence: MNFSIKSVIFLAIVALATLVSASTNPKVTNKVYFDIKQGDKDLGRIVLGLYGEVVPKTVENFRALATGEKGYGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFADENFKLRHTGPGILSMANAGRDTNGSQFFITTVTTSWLDGRHVVFGKVIEGMDVVTAIETTKTLPGDRPATPVIIADCGELPVSNNNDAKAEL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase B, PPIase B, Cyclophilin B, Rotamase B.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: HLGC_STAAN
Sequence: MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity (By similarity).
What are the official names of this protein?
Gamma-hemolysin component C.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
Protein: HNRPF_MOUSE
Sequence: MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
What is the function of this protein?
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.  Plays a role in the regulation of alternative splicing events.  Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein F, hnRNP F.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: BETA_BURCM
Sequence: MTTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDNWSTHKGLENWTYLDCLPYFKKAETRDVGPNDYHGGNGPVSVTTSKPGANPLFEAMVDAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQAKGRPNLEIVTHALADRILFDGKRASGVTYLRGSERASAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDHLEMYIQYECKEPVSLYPALKWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLRSRDPNAHPSILFNYMAEALDWREFRDAIRATREIMRQPALDRYRGRELNPGADCKSDKELDTFVRARAETAFHPSCSCKMGYDDMAVVDEEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRQPLARVDVPYFVANGAMARNVAKAVRQPETV
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: GCSP_SALG2
Sequence: MTQTLSQLENRGAFIERHIGPDAAQQQEMLNAVGAESLNALTGQIVPKDIQLATPPQVGEAATEYAALAELKAIAGRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFDVIVDDAAKALDHQDVFGVLLQQVGSTGEIHDYSALISELKARKVIVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAAVLARAEAAEINLRSDIHNAVGITLDETTTRENVAQLFNVLLGGSHGLNIETLDKDVALDSRSIQQSMLRDDAILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYHQMISQLSDWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLDDLRAKAEQHAANLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKQASQVAILNANYIASRLKDAYPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESEGKAELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISDYQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: SYP_DESRM
Sequence: MRVSQMLVPTLREVPAEAEVVSHQLLLRAGFIRKTASGVYTYLPLAQRVLKKLRQIIREEIDKQGGQELLMPIIQPAEMWLESGRWHVYGPELFRLKDRHDRNFCLGPTHEEVITILIRGEVRSYKQMPLLLYQIQNKYRDERRPRFGLLRGREFIMKDLYSFDRDEAGLDISYQKMHEAYTSIFSRCGVKFRPVEADSGAIGGSSTHEFMVLAESGEAAILYCSDCDYAANVEKATTLPAAGLDPAIQQLELQEVSTPGKKTAEEVAKFLGVEPFQVIKTMFYKTDKEVVAALVRGDRDVNEIKLLNVLGALTLDLADESTVQQVTGAPTGYVGPVGLENIRIVADMEVMALVNAVVGANKQDAHLINVNPKRDFQPEIVEDIRMVKAGEPCPKCGAQLLEARGIEVGQIFKLGTKYSKALGATFLDENGKEQPIVMGCYGIGVSRTMAAAIEQNYDKDGIIWPASIAPYQAIVIPVAPKDDNQMKIAEELYKALNQAGVETILDDRSERPGVKFKDADLIGYPLRIVVGNKAVTEGVVEIRQRRSGQTDLVSVKDSVPKILEILPTL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T112B_ARATH
Sequence: MRLIVHNMLSCNIKGVVNKFPLRIEAEKVTVKEVDFNPDFLRYMFAKIDWKALVDGARSMEYTELPDNAPDTTTLESDETFLRKFHHALLELHLEEGSLVCPETGRKFSVSKGIPNMLLHEDEV
What is the function of this protein?
Acts as an activator of both rRNA/tRNA and protein methyltransferases (By similarity).  Required for TRM9 tRNA methyltransferase activity (PubMed:21653555).
What are the official names of this protein?
Multifunctional methyltransferase subunit TRM112 homolog B, Multifunctional methyltransferase subunit TRM112-like protein At1g78190, Protein SMALL ORGAN 2-LIKE, tRNA methyltransferase 112 homolog B, AtTRM112b.
What is the protein family that this protein belongs to?
Belongs to the TRM112 family.
Protein: RL33_LEPCP
Sequence: MASKGGREKIKLESTAGTGHFYTTNKNKKTTPEKLEFMKFDPKVRKHVLYKEVKLR
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: DGTL1_BORBR
Sequence: MNKDGTVVLMNELASYASDPSKTRGRRHSEPPPENRTEFQRDRDRIIHSNAFRRLEYKTQVFVNHEGDLFRTRLTHSLEVAQIARTLARSLRVSEDLTEAIALAHDLGHTPFGHAGQDELNACMRELAPQAGGFEHNLQSLRVVDELEERYAEFNGLNLCFETREGILKHCSATHARQLGAVGERFLDRTQPSLEAQLANLADEVAYNNHDVDDGLRSGLITLEQLQEVGIFARHYAEVARRYPQLAPRRATSETIRRMINTLIVDLTATSLARIRDHAPASADDVRRAPPLAGFSAAVRREADELKKFLFDNLYRHYRVVRMTTKAQRIVRELFQAFLGDPRLLPPDYRREQPQDQARAISDYIAGMTDRYAIREHRRLFEMG
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: NRDI_MALP2
Sequence: MENKRFFIVYYSSKSNNTHRFMLKLNCKCLRLPIEQKDEPDEILESKIPTVNHPFILLTPTYAGGLGKLKGAVPKPVKKFLNNPVNRNNCKAVIASGNTNFNDTYCIAGDIISQKLQIPFLYKFELLGTNSDVENVIKIGNEFWEKNNF
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: ODO1_BRUME
Sequence: MAKQEQAPDRANDVFALTSFLYGGNADYIEELYAKYEDDPNSVDPQWRDFFAKLGDNADDVKKNAEGPSWTRKNWPIAANGELVSALDGNWAEVEKHVTDKLKGKAAKGEAKGAAGTPLTAEEITQAARDSVRAIMMIRAYRMRGHLHANLDPLGLAEKPNDYNELEPENYGFTPADYNRKIFIDNVLGLEYATVPEMLDILKRTYCGAIGVEFMHISDPAEKAWIQERIEGPDKKVAFTPEGKKAILSKLIEAEGFEQFIDVKYKGTKRFGLDGGESLIPALEQIVKRGGQMGLKEVVLGMAHRGRLNVLSQVMGKPHRAIFHEFKGGSYTPDDVEGSGDVKYHLGASSDREFDGNKVHLSLTANPSHLEIVNPVVMGKARAKQDLLVGRTRDDMVPLSERAKVLPLLLHGDAAFAGQGVVAECLGLSGLKGHRVAGTLHFIINNQIGFTTNPAFSRSSPYPSDVAKMIEAPIFHVNGDDPEAVVFAAKVATEFRMTFHKPVVIDMFCYRRFGHNEGDEPSFTQPLMYKAIRAHKTTVQLYGEKLIAEGLVTQDDIDRMKADWRQKLEGEFEAGQSYKPNKADWLDGAWAGLRTADNADEQRRGKTAVPVKTLKEIGKKLVEVPKDFHVHRTIQRFLDNRAKMMETGEGIDWATAESLAFGSLAVEAHPIRLSGQDVERGTFSQRHTVLYDQENQNRYIPLNNLQKGQAIYEAINSMLSEEAVLGYEYGYSLSDPRALVLWEAQFGDFANGAQVVFDQFISSGERKWLRMSGLVCLLPHGFEGQGPEHSSARLERYLQLCAEDNMQVANVTTPANYFHILRRQMKRDFRKPLIMMTPKSLLRHKRAISTLAELSGESSFHRLLWDDAQYNKDEGIKLQKDAKIRRVVLCSGKVYYDLYEEREKRGIDDVYLLRVEQLYPFPAKALINELSRFRHAEMVWCQEEPKNMGAWSFIDPYLEWVLAHIDAKHQRVRYAGRPAAASPATGLMSKHLAQLAAFLEDALG
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: HPRK_CLOBB
Sequence: MAVSVKRLINDFDLEVLVEGNEDIKIEVNDVNRPGLQLAGFYNYFAPERIQIIGKAEWSFLQDMQIEVRKKRVKKYLSFNITCLIISRDLEPHEEFIKEARKNNIWVLRSKSVTTKLISKITLYLADKLAPETRLHGVLVDVSGIGILITGESGIGKSETALELIKRGHRLITDDAVDIRESDGTLIGSSPKITIGMLEVRGIGIIDVTQLYGLSSVLEEKEIKLIMHFEHWKDDNDYDRLGIDNQYMDILGIPVKKLTVPVRPGRNIAVIIEAAAVNYRYSLMSKISPVDIIENRMSAVSDEA
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: MAO2_RHIME
Sequence: MPGIDKTDRAMTSVTAQEALDFHSQGRPGKLEISPTKPMATQRDLSLAYSPGVAVPVKAIADDPATAYDYTARGNMVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTENVDEFVNCVRFLGPSFGGINLEDIKAPDCFIIEQRLREVMDIPVFHDDQHGTAIIAAAGLVNALTLTGRDFKTAKLVCNGAGAAAIACIELIKAMGFNPENIILCDTKGVIYKGRTDGMNQWKSAHAVETDRRTLAEALDGADVFFGLSAKGALSADMVRSMGARPIIFAMANPDPEITPEEVALIRDDAIVATGRSDYPNQVNNVLGFPYIFRGALDVRASTINDAMKIAAAEALANLAKEDVPDDVAAAYQGNRPRFGPQYIIPVPFDPRLISAIPMAVAKAAMETGVARKPIEDLKAYGQQLSARRDPIASTLQRIVERVRRQPKRIVFAEGEEVQMMRSAIAYANQQLGTALLLGREEVMRETAEREGIDLDRAGIQIVNARLSKRVGAYTDFLYSRLQRKGYLFRDVQRLINTDRNHFAASMVALGDADGMVTGLTRNYSTALEDVRRCIDPKPGHRVIGVSIALCRGRTVLVADTAVHDMPTSEELADIAEEAAGLAKRLGYVPRVAMLAYSTFGHPSGERSERVREAVKILDRRRVDFEYDGEMAADVALNARVMEQYPFCRLSGTANVLVMPAFHSASISTKMLQELGGSTVIGPLLVGLDKSVQIASMSAKDSDLVNLAAIAAYNAGT
What are the official names of this protein?
NADP-dependent malic enzyme, NADP-ME.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
Protein: AKR1_ASHGO
Sequence: MSGQLNVAEDSVLLDDISISSIQPIVSDVPAAEDVGDEDHISGASIAENRPKDPTLVKYHAACQRGDLKTVKDMIEAGVIDVKADWDEEEQVSGLHWASANNRLNLVRYLIAQGADVNIKGGDLEATPLHWASKSGYVYIVHCLLEHGADPLITDRQGYNLLHTSTFSSEVMLITYVLFTGQIPVDSPDPTGKTALHWAAYQGDPNTVEALLKFDADVRVVDTGGFTPLHWATVKGHPHVLKALIEHGSDVFLKNNDGKNALMIAQEMNTQKALQNALYECGFNKDGFAIRKYFKNPMHAKMVTFFTPWLILGLILSFFAYFSILLAILGCLLTVLAAGYGLYNFVFPSFILMKRIVIFKTPLLAGILSGTIFWLLYVWLFKMLPATFDDEPILNLTVFALFAGVVFLLTKLLQSDPGYIVPATDHNQIRATIIELLRVGKYDSKHFCIHSWIRLPLRAKYKRFVHSVILRYDHYCPWIYNYIGFRNHKIFIYFILLLDLGILALAKLCLEYFDELKDHAKNKDALKCSILSKDLCAGFTYDPFTLFLLEWVCVQGMWILALSFVQFFECLKGVTEHEFAHWQRRNRGVVGREHVFNTAPEELMEEDPEEERNKLRSLGAAGQRHCCSTLTTATGFDRFLSVIGSSLGRQPRTTHNPINYPIETDYGWKQNLKDFWLTSDISAPMWRRILLPPVGTRGLLNGQEVDYQKLYNLPERVISIEEIV
What is the function of this protein?
Palmitoyltransferase specific for casein kinase 1.
What are the official names of this protein?
Palmitoyltransferase AKR1, Ankyrin repeat-containing protein AKR1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: AZOR_SHESW
Sequence: MSKVLILKSSILGGYSQSAVLIDHLASHWENQGAAITVRDLGGKDVLPMVDGEIASGLRGGAELSARQQEMLALSDTLVAELKANDTIVIAAPMYNFTIPAQLKNWIDFIARAGVTFTYTETGSKGLVEGKRAVLVTTRGGAHKDGPTDHVVPYLKTVLAFIGITNVEVVYAEALNMGPEAHDKGMSEAKHSIDLLTA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: SBK2_MOUSE
Sequence: MPGKQSEDKPMEVSTVEDGGDEGLGGLTVEELQQGQEAALALEDMMALSAQTLVQTEVEELYEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQSTSLRGFLYEFCVGLSLGTHSAIVTAYGIGIESANSYSFLTEPVLHGDLITFIQPKVGLPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQRVKLTDFGHTRPRGTLLRLTGPPIPYTAPELCAPPPLPEGLPIQPSLDAWALGVLIFCLLTGYFPWDQPLVEVDPFFEDFLIWQASGQPQDRPQPWYSLSPAADTLLWGLLDPHPRKRNPVGSIKSYLGQPWKQREGEAEELATELREDGWRGGQEAAKGEQPAC
What are the official names of this protein?
Serine/threonine-protein kinase SBK2, SH3-binding domain kinase family member 2, Sugen kinase 69, SgK069.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Protein: Y6568_DICDI
Sequence: MQNRYLPYGKMNQCENNYGGNDNILNNNNYNNDDRYNNYKNNNIIENNNYTYNNGGGSKNDKKNIQRNNNSNYNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNYNYNKNNYNKKTYTYRGRVRKYATALFFISTDFILMDDIQIQLKKPIHFYQKYLLIHGNSDNGIKIVLPYKYIGEIKLERFETSFNLSFSTTVTTGRQSARYVIKSLKNEFLIDFKNDLSSVFGNVSFFETDHSLQEMYKQIQFPSQSQPSSFSSSSSSSSIQLSPSPSSSSSPKL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0285557.
Protein: NSG1_MOUSE
Sequence: MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNVAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
What is the function of this protein?
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15187090, PubMed:12070131, PubMed:21084623, PubMed:16037816).  Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:16037816).  Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity).  In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
What are the official names of this protein?
Neuronal vesicle trafficking-associated protein 1, M234, Neuron-enriched endosomal protein of 21 kDa, Neuron-specific protein family member 1, p21.
What is the protein family that this protein belongs to?
Belongs to the NSG family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Cell projection, dendrite. Early endosome membrane. Late endosome membrane. Lysosome lumen. Recycling endosome membrane. Cytoplasmic vesicle membrane. Golgi apparatus, Golgi stack membrane. Endosome, multivesicular body membrane. Endoplasmic reticulum membrane. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes (PubMed:28874679). A previous study supports a type I membrane protein topology (PubMed:12070131).
Protein: RPGR1_HUMAN
Sequence: MSHLVDPTSGDLPVRDIDAIPLVLPASKGKNMKTQPPLSRMNREELEDSFFRLREDHMLVKELSWKQQDEIKRLRTTLLRLTAAGRDLRVAEEAAPLSETARRGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEKPKRGPRDRLSYTAPPSFKEHATNENRGEVASKPSELVSGSNSIISFSSVISMAKPIGLCMPNSAHIMASNTMQVEEPPKSPEKMWPKDENFEQRSSLECAQKAAELRASIKEKVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAELKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSSSQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQKHKQEVELLQNAATISQPPDRQSEPATHPAVLQENTQIEPSEPKNQEEKKLSQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERLTRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLLHQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQYVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGAGGEEFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQEEEFRSESWEPQNELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLTDPAEKPNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMASPEVPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNGNTPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGSEVSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFYDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKFTVVSDPLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQAAAVLHAIYKEMTEDLFS
What is the function of this protein?
May function as scaffolding protein.  Required for normal location of RPGR at the connecting cilium of photoreceptor cells.  Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.
What are the official names of this protein?
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1, RPGR-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the RPGRIP1 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity).
Protein: GER2_HORVU
Sequence: YDPSPLQDFCIAD
What is the function of this protein?
May play a role in altering the properties of cell walls during germinative growth.
What are the official names of this protein?
Germin GS2.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum. Microsome. Secreted, extracellular space, apoplast. Secreted, cell wall. Note=Soluble, microsomal and cell wall fractions.
Protein: Y2013_YERPN
Sequence: MIVYLHGFDSNSPGNHEKVLQLQFIDPDVRFISYSTLHPRHDMQYLLKEVDKAIQQGGDEKSLICGVGLGGFWAERIGFLCGIRQVAFNPNLYPQENMSGKIDRPEEYIDIASKCIDGFREKNRDRCLVVLSRHDEMLDSQRTAGDLHPYYEIVWDDKQNHKFKDLSPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YPN_2013.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: E1BS_ADE12
Sequence: MELETVLQSFQSVRQLLQYTSKNTSGFWRYLFGSTLSKVVNRVKEDYREEFENILADCPGLLASLDLCYHLVFQEKVVRSLDFSSVGRTVASIAFLATILDKWSEKSHLSWDYMLDYMSMQLWRAWLKRRVCIYSLARPLTMPPLPTLQEEKEEERNPAVVEK
What is the function of this protein?
Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis.  Without E1B 19K function, virus production is compromised because of premature death of host cell.  Interacts with Bax protein in cell lysates (By similarity).
What are the official names of this protein?
E1B protein, small T-antigen, E1B 19 kDa protein, E1B-19K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 19 kDa protein family.
What are the subcellular locations of this protein?
Host cell membrane. Host nucleus envelope. Host nucleus lamina. Note=Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina.
Protein: TIG_RICCK
Sequence: MGITVLKNEGLDFHAKISTPLSEIDDDMQKELLDLTKKVKIAGFRAGKVPVSIVKKKYGTSIRNDIIERRINHWVNHVIKEHNLNIIGRPKIEELQNEPDKALEFTVKIEILPKITIPDLKKISLDRPKLEVKPKDVEEQLEKLATLTKSYTKESKVTIKDGDQVTIDAIGYIKDKTFDGGKLNDLKVVIGSNTLIPGFEKQLIGSKTGSEIDVNVTFPENYHAKDLAGKDARFVVQIKAVHTSEPTLIDDEFAKKFQSNNLEELRTHFAKQIENESEEAINTIMKMNLFDKLEKLLDFDVPESLLEQEKNILKSETDKDESLLKDKSSKEITEYYNKLALRRVRIGLLLAEYAKSKNLQLEPDDFKKVIIQQARNFPGQENMIFDFYKNNPKAIEALKGTALEDKVVQYIFNNEIKLKEKKYTKEELEKYLEEEEQRITLI
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: UQCC3_XENLA
Sequence: METVRRIVKGTLLLGFCTGIGGDLWVLVAPGQERRLEMRMNYPEANPPMLAEAHKRNEMVLKVIEESAKTNENMARRSPWSS
What is the function of this protein?
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex.  Thereby, plays an important role in ATP production by mitochondria.  Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 3, Oocyte antigen VAP18.
What is the protein family that this protein belongs to?
Belongs to the UQCC3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.