Protein: ATG2_COCIM
Sequence: MPFSLPSFAQKLVLRYALSRLGLVDTDTLDLATLGITWGQRSTFELRNVGLKLEKLSAHLPPYCTLTKGSVSLLRVTVPANLHNSSIIVEVDGVDARVRLLPDKPEQNAPPTRSKGTAEDEGQDGHSVLPSTADLAQSFLESEPKEETEELQAAILSQSQYPEHLDAQSDDGEEDLGLYDGLSLPAFIAGFLKGVIDRLQLNIANVSLRVDTEVQRDGVLKDETQDPISGLFTIQEIAIDSTATSASEDSRLKIGKRMVSLSGIHAMIMSDAEVFSNYSRFNAPDIPSTVHSKSTHTPLRPRSPQPSSSGSDSCGDMSRSTILDPSSMYGSRLTVDSHGDESRHLESSVYSTTGRFSDADSDDENDLEFYSQATTGMLDSHYDERLLDNPAYLDEALKSQFDDHLEDSTIFPKDCPSTPVRDQTPRPHVSKSPSSSPEHYMYHSVHESNFPVGGGIRDNEPDSATSARGKTPDCQTEQESPSTSKICPAVSQPEDLSASRIFTHEEAQSMYMSAMSQSSTTSFDPDMPGAWGSSKRIDTSDPDQKEQPLSGDTDTEAKGASHDFDTSQNSPEAQTGEDDERESVHNSPQYISGVVKEILAIDRIIIWLPSVDSQDSEEIPKTDIDSKPVDPMVESTITLADSVTPDLLANTRSRLAQSAFRRGSVSSIVSSRHLPISRTKPTTQKHEDFDGLNDPQTTRAVEIDITSLTAKLDIASGWLLVKIGQRITDVSTSTSKQTKISEAASEESSPSFFRLNLTSCSLKFLERVPAQPYPLSSAPSLSQLQSGIPIEETILHLTLSGTSIDFAAIGNTTKLRLDVMKFVLGHMSYDIISFDESLRMRESTRDVTSPGQKDISLRVIKSSESTTVNLTTLPICLSLDLQELDETLGWFGGLSTVLELGSSIASASTVKGEQPCSPPRPRRGVHFADPVPPSSPSTTNHAALKANCRIGGIVLRVIGEHCTVQLGTTAAKLVSRFEGIALQIDKASVGGPHLRKEPSPSPPSLDFENIRFEYLYGPKEVDLDRLLGLLTPSKDKFDEDDDIMLDTLFRQRRQGAVLRLTVGHADFAVPNPTALQPLSHLGEELAKLATVAKYLPQDDRPGILILALVREFEGRVHVNNEAGDITIISHNLEAGYVTFPSLLATRISTVTVVRNGSEELVAEVIPEDTEEARTHDPLPMIMARFIADEMEPTVKIKLYNVRVEYTVPSITAFLGLNNQMAAEDVAANMAQSVLNLADLKAHHEPGSDLSERDSIGSGDDRSAMLPRLSVGMKDCGIGLNPRKSPAKALVIFTRASFSGALHETKPSEALLDIRKASVMIIDNVENLGSAENYRHRMSSGARSGQIQHLQSIGFVPVCDISSASVALKVMQLDVEGEKSLDIEVRDDLLVLETCADSTQTLISILSGLAPLSPPITERKYRTEVIRIEDMLNSLSGDAFATDIVPDSDYEVEGENDGQDGDGAEEIEYVSVFYPSHGDSGPQGRGATTPRFGNEGSASAGTSRILGSFHSEAQMSSSIPELEFQEDHFAKQSAVGDTAHRWDSSRNTYTLATEVKLRDSPLRIRVRDVHVIWNLYDGYDWQRTRDTISKAVRDVQAKAAEKFARRPGNRLSADFEEDEESVIGDFLFNSVYIGIPANRDPRELSHDINRNIDDLASETMSFATSTTVTGLQNQVPGTKREKLRLARSKHHKMTFELKGISADLIVFPPHSGETQSSLDIRVEDLEIFDHIPTSTWKKFATYMRDVGEREIGTSMVHLEILNVKPVPDLAASEVVLKATVLPLRLHVDQDALDFLSRFFEFKDDSAPSEPSPEDVPFLQRAEVNAIRVRLDFKPKRVDYAGLRSGRTTEFMNFFVLDEADMVLQHVIIYGVSGFDRLGRTLNDIWMPDIKANQLPTVLAGIAPVRSLVNIGGGVKDLVLVPMREYKKDGRIVRSIQKGAVQFAKTTTNELLRFGAKLAIGTQTALQSAEDFLNSPRGSPSRPSTSDGRWDDNGVDEGERPRISLYADQPLGVAQGLRGAYSSLERDILMTRDAIVAMPSEVLESGSATEAARRLLGRTPTVVLRPAIGASKAVSQTLLGVSNALDPKNRRKIDDKYKKHKV
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an ATG18-PtdIns3P interaction.  ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.