PharMolix/UniProtQA huggingface dataset:
Protein: DNE1_CHLMO
Sequence: MSNFILKPGEKLPQDKLEELKKINDAVKKTKNFSKYLIDLRKLFQIDEVQVTSESKLFLAGFLEGEASLNISTKKLATSKFGLVVDPEFNVTQHVNGVKVLYLALEVFKTGRIRHKSGSNATLVLTIDNRQSLEEKVIPFYEQYVVAFSSPEKVKRVANFKALLELFNNDAHQDLEQLVNKILPIWDQMRKQQGQSNEGFPNLEAAQDFARNYKKGIK
What is the function of this protein?
Endonuclease involved in intron homing.  Recognizes a degenerate sequence of 17-19 bp to produce a staggered cut 5 bp downstream from the CeLSU. 5 intron insertion site.
What are the official names of this protein?
DNA endonuclease I-CeuI, 23S rRNA intron 1 protein.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MTBS_BPSPR
Sequence: MGKLRVMSLFSGIGAFEAALRNIGVGYELVGFSEIDKYAVKSFCAIHNVDEQLNFGDVSKIDKKKLPEFDLLVGGSPCQSFSVAGHRKGFEDTRGTLFFQYVETLKEKQPKFFVFENVKGLINHDKGNTLNVMAEAFSEVGYRIDLELLNSKFFNVPQNRERLYIIGIREDLIKNEEWSLDFKRKDILQKGKQRLVELDIKSFNFRWTAQSAATKRLKDLLEEYVDEKYYLNEDKTNSLIKELSTSRLNENLTVEQVGNINPSGNGMNGNVYNSSGLSPTITTNKGEGLKIAVEYSRKSGLGRELAVSHTLSASDWRGLNRNQKQNAVVEVRPVLTPERGEKRQNGRRFKDDGEPAFTVNTIDRHGVAVGEYPKYRIRRLTPLECFRLQAFDDEDFEKAFAAGISNSQLYKQTGNSITVTVLESIFKELIHTYINKESE
What is the function of this protein?
A methyltransferase that methylates the C-1 in the sequence 5'-GGCC-3' and both cytosines in the sequence 5'-CCGG-3' (Probable).  A methyltransferase that methylates C-3 within the sequence 5'-GGCC-3', C-1 in 5'-CCGG-3' and C-2 in 5'-CCWGG-3'.  Modification confers resistance against restriction enzymes that recognize these sequences (PubMed:12654995).
What are the official names of this protein?
Orphan methyltransferase M.SPRI, M.SPRI, Cytosine-specific methyltransferase SPRI, Modification methylase SPRI.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: K1328_HUMAN
Sequence: MADVAGPSRPSAAAFWSRDFSDEEQSVVYVPGISAEGNVRSRHKLMSPKADVKLKTSRVTDASISMESLKGTGDSVDEQNSCRGEIKSASLKDLCLEDKRRIANLIKELARVSEEKEVTEERLKAEQESFEKKIRQLEEQNELIIKEREALQLQYRECQELLSLYQKYLSEQQEKLTMSLSELGAARMQEQQVSSRKSTLQCSSVELDGSYLSIARPQTYYQTKQRPKSAVQDSASESLIAFRNNSLKPVTLHHPKDDLDKIPSETTTCNCESPGRKPAVPTEKMPQEELHMKECPHLKPTPSQCCGHRLAADRVHDSHPTNMTPQHPKTHPESCSYCRLSWASLVHGGGALQPIETLKKQISEDRKQQLMLQKMELEIEKERLQHLLAQQETKLLLKQQQLHQSRLDYNCLLKSNCDGWLLGTSSSIKKHQDPPNSGENRKERKTVGFHSHMKDDAQWSCQKKDTCRPQRGTVTGVRKDASTSPMPTGSLKDFVTTASPSLQHTTSRYETSLLDLVQSLSPNSAPKPQRYPSREAGAWNHGTFRLSPLKSTRKKMGMHRTPEELEENQILEDIFFI
What is the function of this protein?
Competes with SMC1 for binding to SMC3.  May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.
What are the official names of this protein?
Protein hinderin.
Protein: UL33_HCMVA
Sequence: MDTIIHNSTRNNTPPHINDTCNMTGPLFAIRTTEAVLNTFIIFVGGPLNAIVLITQLLTNRVLGYSTPTIYMTNLYSTNFLTLTVLPFIVLSNQWLLPAGVASCKFLSVIYYSSCTVGFATVALIAADRYRVLHKRTYARQSYRSTYMILLLTWLAGLIFSVPAAVYTTVVMHHDANDTNNTNGHATCVLYFVAEEVHTVLLSWKVLLTMVWGAAPVIMMTWFYAFFYSTVQRTSQKQRSRTLTFVSVLLISFVALQTPYVSLMIFNSYATTAWPMQCEHLTLRRTIGTLARVVPHLHCLINPILYALLGHDFLQRMRQCFRGQLLDRRAFLRSQQNQRATAETNLAAGNNSQSVATSLDTNSKNYNQHAKRSVSFNFPSGTWKGGQKTASNDTSTKIPHRLSQSHHNLSGV
What is the function of this protein?
G-protein-coupled receptor (vGPCR) that constitutively activates multiple oncogenic signaling pathways including STAT3, AP-1, phospholipase C, NF-kappa-B or cAMP-responsive element (CRE) pathways (PubMed:14522997).  Plays an important role in viral reactivation from latency through activation of host CREB1, facilitating its recruitment to the viral major immediate early (MIE) genes.  In turn, expression of the MIE-driven genes such as UL123 are de-repressed.  Facilitates also virus dissemination via the extracellular and cell-to-cell route (By similarity).
What are the official names of this protein?
G-protein coupled receptor homolog UL33, vGPCR UL33.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Virion. Host cell membrane; Multi-pass membrane protein. Host cytoplasm. Note=Present in the virion assembly compartment (VAC) of HCMV-infected cells.
Protein: HUTH_GLOVI
Sequence: MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFKNRRIPRSAVEQLQQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALVLTGEGEAEVGGEVLPGAAALARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSAFLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAISYAAGVIAIEINSVTDNPLIFADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRTERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSENKVLAHPACVDSIPTSAGQEDHVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHLESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHER2_VIBCH
Sequence: MNEIVITDTDFCRFRDYFYQKTGIFFENSKRYFVDKRLLQRIELTEHQSFRGYFTYLRFQASGEELQAVINALTVNETYFFREISQLESLVEEVLDDIVRHRPGELIRIWSMPCSSGEEPYSIVLFLLEHWPKLEQVDIEIIASDIDTGILQKAAQGIFSARSVKNLPNSSLNKYFSLRADGSYQLIDDIRQSVRFTQTNLNNRAEVQKLGAMDVIFCRNLLIYFDDISRRNAVESFYEQLNPGGVLFLGHSESMSRISSIFHVKRFRKSTGYYKPHKGKSDEKSNGR
What is the function of this protein?
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
What are the official names of this protein?
Chemotaxis protein methyltransferase 2.
Protein: ZN572_HUMAN
Sequence: MEQEKKLLVSDSNSFMERESLKSPFTGDTSMNNLETVHHNNSKADKLKEKPSEWSKRHRPQHYKHEDAKEMPLTWVQDEIWCHDSYESDGKSENWGNFIAKEEEKPNHQEWDSGEHTNACVQQNSSFVDRPYKCSECWKSFSNSSHLRTHQRTHSGEKPYKCSECAKCFCNSSHLIQHLRMHTGEKPYQCGECGKSFSNTSHLIIHERTHTGEKPYKCPECGKRFSSSSHLIQHHRSHTGEKPYECSVCGKGFSHSYVLIEHQRTHTGEKPYKCPDCGKSFSQSSSLIRHQRTHTGEKPYKCLECEKSFGCNSTLIKHQRIHTGEKPYQCPECGKNFSRSSNLITHQKMHTGEKSYESSEYEESLGQNCNVIEECRIQLGEKPYRCCECGKSFGLSSHLIRHQRTHTGEKPYRCSECWKTFSQSSTLVIHQRTHTGEKPYKCPDCGESFSQSFNLIRHRRTHIGEKPYKCTSCEKCFSRSAYLSQHRKIHVEKPFESPDVGDFPHEWTWKNCSGEMPFISSFSVSNSSS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 572.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OMPA_SHIDY
Sequence: MKKTAIAITVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFIDNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYKAQGVQLTAKLGYPITDDLDVYTRLGGMVWRADTKAHNNVTGESEKNHDTGVSPVFAGGVEWAITPEIATRLEYQWTNNIGDAHTIGTRPDNGLLSLGVSYRFGQGEAAPVVAPAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA
What is the function of this protein?
Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
What are the official names of this protein?
Outer membrane protein A, Outer membrane porin A.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: RS10_XANCB
Sequence: MADQKIRIRLKAFDHRLIDRSASEIVETAKRTGAQVRGPIPLPTKIERYTILVSPHADKDARDQYETRTHKRVLDIVDPNDKTVDALMKLELAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RNC_SHESW
Sequence: MEPIKNLPRLCRTLGYEFTQIELLTQALTHRSAANKHNERLEFLGDSILSIVISDALYHQFPKATEGDLSRMRATLVRGDTLTIIAQEFKLGDYLYLGPGELKSGGFRRESILADAVEAIIGAIYLDSDLEVCRKLLLTWYAERLAEIQPGVSQKDAKTLLQEYLQGLKKPLPDYQVINIEGDAHDQTFTVECRIEDLSQSVIGVASSRRKAEQIAAAQVLELLKK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBH6_SCHPO
Sequence: MDGMHMNSTGDNPIEIDFENYANHMNKFLMAHIICMIIAYVFILPAGIVLAMAKSKAHIPVQIVYVILTLIGYIFAHISHHKASPENYYKGNIHRPVGRFFMWITFLIAIVGITTSILKKRMLKEYQPAAEAPGAMEDPEQALQRNSLDDGAPLLPREGNSSDEYLPPQSSRRDVSSEKPSIPSISFINIRSWRTIPKKWCVLQVLRYFHRILGHLWLYVGFFESCTGIVLLAGIFKGQHIFNGLAHWIKGAIFLWYGILSFGEYLGAFSEYGWAWNVVPKQLSEKRFAKYVPTKEMVESFLLFAYGVSNVWLEHLGNTDGKWNHHDLQHASLAFMLWWAGLCGILVESKVVHRLLNATLSATLGQRRSEDSEHSENGLPSYNVFPALTVFFTGIMMSAHDQTNHVSTVIHVLWGRLLAAAAIARICTYIMLYLKPPSSPWPTRPPTEIITSFCLICGGAMFMASSYDVVNKIRLNEMSPMLIMNISVAFTCIVMGLEVMFLILKGYASSR
What are the official names of this protein?
Uncharacterized membrane protein C3B8.06.
What is the protein family that this protein belongs to?
To yeast YCR061W.
Protein: ITH5_CUCMA
Sequence: SSCPGKSSWPHLVGVGGSVAKAIIERQNPNVKAVILEEGTPVTKDFRCNRVRIWVNKRGLVVSPPRIG
What is the function of this protein?
Specifically inhibits both trypsin and activated Hageman factor.
What are the official names of this protein?
Inhibitor of trypsin and hageman factor, CMTI-V.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.
Protein: RTC5_VANPO
Sequence: MGQTPSVESQESKETKNEMPELKSREDILDFFNNRSLSILLPMEIECFKSRLGDKDLSDPLTKDEFNTLLRIADSNSQLQILLWNFFLKISAFPFLSNRSESMTGFGILKGIILLTRERIKKYLGWSNAKLIKLIFIGLTSQEKVGVKTEASVFKIQHVLDTLDGIDLASSTVKDTDMLSFITWLLLLSVHCPTSNCKLNEKSLYDKWKDYEIVASSMVRSMNKKITTTGKGIGISYSDFSHTIVAVSKNVMSPLENIVEHMLYKQDDLLEFPCLDTFLKETKLMTYPLVAQLCTVLPNEIVMSQLQKLYVGRESGYSMRSLQSKVFNWKAATILLVSGTRIVDDIEYSENKNPRYKRFLEEYPKLKDEDQEMDDCHNLKKKVTFAVYIDEPWRVTNKNYFGEKRTSIIELSPRQDKFNSLKVGSVYFNTIGGGIGIGNNQPVTKLNSVRYAPGNVSLTLDNTLEFGVFRHTGYGGTIGPSELLKKNNEENKAFEIRFLIRDVEVWGCGGEKELEEQLREWKWEEAEAKRRQEINLKTMGEDRALLEMAGIIGQHGQSGGSI
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_STAAN
Sequence: MPRVKGGTVTRARRKKTIKLAKGYFGSKHTLYKVAKQQVMKSGQYAFRDRRQRKRDFRKLWITRINAAARQHEMSYSRLMNGLKKAGIDINRKMLSEIAISDEKAFAQLVTKAKDALK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: TYOBP_MOUSE
Sequence: MGALEPSWCLLFLPVLLTVGGLSPVQAQSDTFPRCDCSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSRGQGTAEGTRKQHIAETESPYQELQGQRPEVYSDLNTQRQYYR
What is the function of this protein?
Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:15471863, PubMed:9647200).  TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:15728241).  Also has an inhibitory role in some cells (PubMed:21727189).  Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity).  Also mediates cell activation through association with activating receptors of the CD200R family (PubMed:15471863).  Required for neutrophil activation mediated by integrin (PubMed:17086186).  Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity).  Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity).  Also associates non-covalently with the NK cell receptors KLRA4/LY49D and KLRA8/LY49H which leads to NK cell activation (PubMed:9647200).  Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity).  Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity).  Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693).  Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) which is produced by TREM2 ectodomain shedding (By similarity).  In microglia, required with TREM2 for phagocytosis of apoptotic neurons (PubMed:15728241).  Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038).  Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (PubMed:25690660).  Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (PubMed:21257958).  Negatively regulates B cell proliferation (PubMed:21727189).  Required for CSF1-mediated osteoclast cytoskeletal organization (PubMed:18691974).  Positively regulates multinucleation during osteoclast development (PubMed:12569157, PubMed:14969392).
What are the official names of this protein?
TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein.
What is the protein family that this protein belongs to?
Belongs to the TYROBP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SLMA_SALAR
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTSARLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYATDENLLASQLLAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: AROK_SHEHH
Sequence: MAEKRNIFLVGPMGAGKSTIGRHLAQMLHLEFHDSDQEIESRTGADIAWVFDVEGEEGFRNRETQVVADLTEKQGIVLATGGGSIQSKEIRNNLSARGIVVYLETTIDKQVARTQRDKRRPLLQVDDPREVLENLAEVRNPLYEEIADVIVKTDEQSAKVVANQIIEQLGF
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_SHESA
Sequence: MSLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLMVLNDNEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSQFKKPATKPGLPTFSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGSATGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHDVLVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGMLAQINAFLAD
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: TRUB_FRATN
Sequence: MKKNRLNLNGVVVINKAKDVSSNKVLQQLKYLFNAQKAGHTGTLDPMATGVLPICFGRATKIAQYLLDADKEYIATIRLGIETDSGDAEGEIIAKSPNIPELSAEYLETVLAKFRGDVVQIPPMYSALKYNGQPLYKLAREGKTVEVKSRNIKIYELELLEFDIDSLKIRVKCSKGTYIRSLAIDIGKTLGCGGHLIALQRTQSGPFKLSEAFRLEQLKDLSFEQKIASITNIESVFIDKPIYSLLEEEKDDLYKRGLFADKPHLDGTVRIYDDEKFVAIAEFDKGKLINKKFFDQDILISE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: YNGF_BACSU
Sequence: MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIEFNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIAAINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKEFIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGLETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI
What are the official names of this protein?
Putative enoyl-CoA hydratase/isomerase YngF.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: CYB_PANOS
Sequence: MSNQHMLLLFNLLPVGSNISTWWNFGSMLLTCLALQTMTGFFLAIHYTANINLAFSSIVHITRDVPYGWMMQNLHAIGASMFFICIYIHIARGLYYGSFLNKNVWLSGTTLLIILMATAFFGYVLPWGQMSFWAATVITNLLTAVPYIGTELTNWLWGGFSINDPTLTRFFALHFILPFTIISMSSIHIMLLHTEGSSNPLGTNSDIDKIPFHPYHSHKDMLMLTIMMTALFIIMSFMPNIFNDPENFSKANPLVTPQHIKPEWYFLFAYGILRSIPNKLGGTVALVLSVTILMTMPFTHTSHFRSMTFRPLMQFMFWTLVATFITITWAATKPVEPPFTTIGQATAILYFTFFIMNPLLGWLENKISITNM
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PURQ_STAAN
Sequence: MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLATEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PITM2_HUMAN
Sequence: MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK
What is the function of this protein?
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro).  Binds calcium ions.
What are the official names of this protein?
Membrane-associated phosphatidylinositol transfer protein 2, Phosphatidylinositol transfer protein, membrane-associated 2, PITPnm 2, Pyk2 N-terminal domain-interacting receptor 3, NIR-3.
What is the protein family that this protein belongs to?
Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein.
Protein: B2KB4_SICCD
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDLDKGGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPLVEDYEFIRAFKDTLKNEGYESYNDKVGINFTGNEDLDKICDVLEILGFHKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRTLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1biv, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.