PharMolix/UniProtQA huggingface dataset:
Protein: ATPF_LACDB
Sequence: MEFQPVFAGAEISIINTLWYLIVFSILLLAVKHYAWGPVKDMMEKRRQKVIDDLDQAASDRKKAETLANEREAALKNSRQEATQILSDAKSNAQKTGKQIVSEAMAEASAIREKAKADAAQAETDALNEAREEVADLSVTIAEKVIAKNLSAADQKDLVDQFIKGLND
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SYR_BURTA
Sequence: MLPAQKHTLETLLENSVKQVVQASKGDADAAFVLPAIALERPKVAAHGDVACNVALQLAKPLGANPRQLAERIVAALTAQPAAAGLVDAAEIAGPGFINLRLTPASKQAVIGAVFAQGRAFGASEREHGKRVLLEFVSANPTGPLHVGHGRQAALGDALANVLASQGYAVHREFYYNDAGVQIGNLAISTQARARGLKPGDAGWPEAAYNGEYIADIARDYLNGETVAASDGEPVTGKRDADDLEAIRKFAVAYLRREQDMDLKAFGVKFDQYYLESSLYTEGRVEKTVDALIAAGMTYEQEGALWLRTTDEGDDKDRVMRKTDGTYTYFVPDVAYHVTKWERGFTKVINIQGSDHHGTIARVRAGLQGLHIGIPKGYPDYVLHKMVTVMRDGQEVKISKRAGSYVTVRDLIEWSGGATPGSEVSPELLDEATITRGRDAVRFFLISRKADTEFVFDIDLALKQNDENPVYYVQYAHARICSVLNEWKSRYGATDALLPGADLSPLDSKQAMALMQKLAEYPDVLAHAANELAPHAVAFYLRELASEFHSFYNAERVLVDEEAPRTARIALLAATRQVLENGLAMLGVSAPSKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBP1_THET8
Sequence: MTPEAAYQNLLEFQRETAYLASLGALAAWDQRTMIPKKGHEHRARQMAALARLLHQRMTDPRIGEWLEKVEGSPLVQDPLSDAAVNVREWRQAYERARAIPERLAVELAQAESEAESFWEEARPRDDWRGFLPYLKRVYALTKEKAEVLFALPPAPGDPPYGELYDALLDGYEPGMRARELLPLFAELKEGLKGLLDRILGSGKRPDTSILHRPYPVEAQRRFALELLSACGYDLEAGRLDPTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPKEHWGTPRGDAVSLGVHESQSRTWENLVGRSLGFWERFFPRAREVFASLGDVSLEDFHFAVNAVEPSLIRVEADEVTYNLHILVRLELELALFRGELSPEDLPEAWAEKYRDHLGVAPKDYKDGVMQDVHWAGGLFGYFPTYTLGNLYAAQFFQKAEAELGPLEPRFARGEFQPFLDWTRARIHAEGSRFRPRVLVERVTGEAPSARPFLAYLEKKYAALYG
What is the function of this protein?
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro.  Has lower activity with substrates ending with Gly or Glu.
What are the official names of this protein?
Thermostable carboxypeptidase 1, TthCP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M32 family.
Protein: SKIT1_MOUSE
Sequence: MGSTGLCFYGHCIVMFLLQMVTASSEPFIVNGLEGPVLASLGGNLELSCQLSPPQQAQHMEIRWFRNLYTEPVHLYRDGKDMFGEIISKYVERTELLKDGIGEGKVTLRIFNVTVDDDGSYHCVFKDGDFYEEHITEVKITAINLQVQIHVHPPNTKGVIVECHSGGWFPRPLMQWRDRRGEVIPAASKSHSQGRDKLFNMKISLLISESFFQKVICCLQNPLTGQEERTSVILSDAFFSWNRIWKMILGIILSMMVVSIFVFSCLLHHEHKVCKWKWDAPWIKGLLIMTSSMVTVVLVMVYLHMKQRVPVSDVHFELDTLWVEDISVILCSLMVPATMLVSYTYFRLKDWCQHNHAQRVFTSN
What is the function of this protein?
May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus.  Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells.
What are the official names of this protein?
Selection and upkeep of intraepithelial T-cells protein 1, Skint-1, Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1.
What is the protein family that this protein belongs to?
Belongs to the SKINT family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VDTC1_BYSSP
Sequence: MAEEIKLTPLETFAQAISASAKTIATYCRDSGHPQLSDDNSSGLTGDVLPPSAPQAVTAARQTILEASYRLQQLVTEPSQYLPRLTVYPQHLAALRWLCHFRIPELIPVQGTRTYYELATEAKVPLHQLQSIARMAITGSFLREPEPNIVAHSRTSAHFVENPSLRDWTLFLAEDTAPMAMKLVEATEKWGDTRSKTETAFNLALGTDLAFFKYLSSNPQFTQKFSGYMKNVTASEGTSIKHLVNGFDWASLGNAIVVDVGGSTGHASIALAESFPDLKFIVQDLPMVTSTSKDNREKTPLPETVASRISFESHDFFKPQPVQNADVYLLRMILHDWSFKEAGEILANLVPSVKQGARILIMDTVLPRHGTVPVTEEALLRVRDMTMMETFNSHEREIDEWKDLIQGVHTGLRVQQVIQPAGSSMAIIEVVRG
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of viriditoxin, one of the 'classical' secondary metabolites produced by fungi and that has antibacterial activity (PubMed:31304040, PubMed:31045362).  The first step is performed by the polyketide synthase VdtA which condenses one acetyl-CoA and 6 malonyl-CoA units to form the heptaketide monomer backbone of viriditoxin (PubMed:31304040).  The product of VdtA is then O-methylated on C7 by the O-methyltransferase VdtC (PubMed:31304040, PubMed:31045362).  The O-methyl group is important for the stereoselective coupling of the monomers at the final step of viriditoxin biosynthesis (PubMed:31304040, PubMed:31045362).  The short-chain dehydrogenase/reductase VdtF then acts as a stereospecific reductase converting the pyrone to dihydropyrone via the reduction of the C3-C4 double bond (PubMed:31304040, PubMed:31045362).  The FAD-binding monooxygenase VdtE then converts the ketone group into a methyl-ester group to yield semi-viriditoxin (PubMed:31304040, PubMed:31045362).  Finally, the laccase VdtB is involved in dimerization of 2 semi-viriditoxin molecules to yield the final viriditoxin (PubMed:31304040, PubMed:31045362).  VdtB is responsible for the regioselective 6,6'-coupling of semi-viriditoxin, which yields (M)-viriditoxin and (P)-viriditoxin at a ratio of 1:2 (PubMed:31304040, PubMed:31045362).  The non-catalytic carboxylesterase-like protein VdtD affects the stereochemistical outcome of the coupling (PubMed:31304040, PubMed:31045362).  The highly reducing polyketide synthase VdtX is not involved in viriditoxin synthesis, but might possibly play a role in the production of additional metabolites not identified yet (PubMed:31304040, PubMed:31045362).
What are the official names of this protein?
O-methyltransferase VdtC, Viriditoxin biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: RHAD_ECOK1
Sequence: MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQILVKVYSMGGMKQTISREELIALGQRFGVTPLASALAL
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB3_CAEEL
Sequence: MSIMSYTGGTVVAMAGDECVCIASDLRIGEQMTTIATDQKKVHKVTDKVYVGLAGFQSDARTVLEKIMFRKNLYELRENRNIKPQVLSEMISNLAYQHRFGSYFTEPLVAGLDDTNKPYICCMDTIGCVSAPRDFVAVGTGQEYLLGVCENFWRENMKPDELFEATAQSILSCLERDAASGWGAVVYTITKDKVNVSTIKARMD
What is the function of this protein?
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Proteasome subunit beta type-3, Proteasome subunit beta 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EUTC_SALA4
Sequence: MDQKQIEEIVRSVMASMGQDVPQPVAPSTQAGAKPQCAAPTVTESCALDLGSAEAKAWIGVENPHRADVLTELRRSTAARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLSPEAIDALKSQCVMNPDVQVVVSDGLSTDAITANYEEILPPLLAGLKQAGLNVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRVATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: DNAA_BRUME
Sequence: MKMDSAVSEEAFERLTAKLKARVGGEIYSSWFGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELWQEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVTPREKMVFPVGQSFGGQSLGEKRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPLFIHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRDIDLLVIDDMQFLQGKSIQHEFCHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGGVALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAHVARTVTGSGRELEGAFNQLLFRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIVKPRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRLINDQAA
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_STRR6
Sequence: MKRILIALVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFKGVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SAP1_ARATH
Sequence: MGSEQNDSTSFSPSEPKLCVKGCGFFGSPSNMNLCSKCYRDIRATEEQTASAKAAVEKSLNPNKPKTQPQQSQEITQGVLGSGSSSSSTRGGDSAAAPLDPPKSTATRCLSCNKKVGVTGFKCRCGSTFCGTHRYPESHECQFDFKGVAREAIAKANPVVKADKVDRI
What is the function of this protein?
May be involved in environmental stress response.
What are the official names of this protein?
Zinc finger A20 and AN1 domain-containing stress-associated protein 1, AtSAP1.
Protein: YCCT_ECODH
Sequence: MKTGIVTTLIALCLPVSVFATTLRLSTDVDLLVLDGKKVSSSLLRGADSIELDNGPHQLVFRVEKTIHLSNSEERLYISPPLVVSFNTQLINQVNFRLPRLENEREANHFDAAPRLELLDGDATPIPVKLDILAITSTAKTIDYEVEVERYNKSAKRASLPQFATMMADDSTLLSGVSELDAIPPQSQVLTEQRLKYWFKLADPQTRNTFLQWAEKQPSS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: GLIG_ASPFU
Sequence: MSERPSDLVVNRLVLFVVKGTATSTHNTVKPLILLEELGVPHDIYVVEKVSAPWFSEINPHKMVPAILDRSPDGRDTLRAWESTSTLMYIADAYDKDGTLGGRNVQERSEINNWLTLHTAALGPTAKYWLYFYKLHPEKLPKTIEKLRSNITVQYDILERRLNEPGQQYLALKDRPTIADIATLPFAMKSTAELFGLEFEKWPKLQEWSVRMGEREAVKRAWQRVAGFGHGEKEYGMLEA
What is the function of this protein?
Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide (PubMed:15979823, PubMed:21612254).  The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP (PubMed:17154540, PubMed:21612254).  GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp (PubMed:23434416).  The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain (PubMed:24039048, PubMed:23434416).  The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin (PubMed:21513890, PubMed:21749092).  This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties (PubMed:22903976, PubMed:24039048).  Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure (PubMed:20548963, PubMed:22936680, PubMed:24039048, PubMed:25062268).  GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides (PubMed:25062268).  Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA (PubMed:26150413).  Gliotoxin contributes to pathogenesis during invasive aspergillosis (PubMed:17601876, PubMed:18199036).  In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species (PubMed:17601876).
What are the official names of this protein?
Glutathione S-transferase gliG, Gliotoxin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: ACE2_YEAST
Sequence: MDNVVDPWYINPSGFAKDTQDEEYVQHHDNVNPTIPPPDNYILNNENDDGLDNLLGMDYYNIDDLLTQELRDLDIPLVPSPKTGDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRGLSGTAIFGFLGHNKTLSISSLQQSILNMSKDPQPMELINELGNHNTVKNNNDDFDHIRENDGENSYLSQVLLKQQEELRIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEEQEEVAQKLVSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSINGSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNNTSDKNNNDKKNSTGDNIFRLFEKTSPGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGTFTPRTQLSPIHKKRESVVSTVSTISQLQDDTEPIHMRNTQNPTLRNANALASSSVLPPIPGSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHCEVESYPQVPPVTHDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPDKLFECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISHNAKKYICPCGKRFNREDALMVHRSRMICTGGKKLEHSINKKLTSPKKSLLDSPHDTSPVKETIARDKDGSVLMKMEEQLRDDMRKHGLLDPPPSTAAHEQNSNRTLSNETDAL
What is the function of this protein?
Plays a role in regulating basal-level expression of CUP1.  Activates EGT2 transcription in the absence of SWI5.
What are the official names of this protein?
Metallothionein expression activator.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRL31_ARATH
Sequence: MAFENLKISRHISSSTKNLLKAKKIMAALASNPQMLTRQAHGNKKEQLWRKESLNLEKKCGFCVSVYSNEKLGRSHMEKEWRLKAFWSNIAQPTTLEMEPINNVEELDAVLSHARQLSQPIIIEWMASWCRKCIYLKPKLEKLAAEYNNRAKFYYVDVNKVPQTLVKRGNISKMPTIQLWKEDEMKEEVIGGHKGWLVIEEVRELINKFV
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Thioredoxin-like 3-1, chloroplastic, Thioredoxin WCRKC-1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: MRAZ_ACIF2
Sequence: MFRGTHRHSLDSKGRMNVPARFRDWLNAHCDGQLVVTIDAQSQKGERCLVAYPLPTWEKVERRIAELPSNNPAARQFQRLFVGQSEELRLDAQARILLSPNLRKFAELDKELVLVGQIDKFEIWDAARWDACQETWLSGADGFACLGDLVL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MSCL_CAUVC
Sequence: MSVVKEFREFIARGNVIDLAVGVIIGAAFNGIVKSLVDQVIMPPIGLLTGGLDFSKLEWVLRPEDPASEAIEKVAIQYGAFVNTVIQFFIVATVVFLLVKLVNEIRRQDAAEPAPAAPPAPTAEETLLTEIRDLLAKKG
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y2340_DICDI
Sequence: MTTTISQLNITPIKFTINDLIVDPVSLSENFNCPICEECIMDVNKCEALQCKEGHVHCRLCWMKSLESKKECMTCRTRVNSVDSLSKNIYLQKEFRNKKIFCPNLFRILNSGKIEIDEKFGCKEILKVDELEGHIKECQFQFIECPNDKECKTRLRKNQLKDHAEKCKKLKSECEFCGEKGLVIDDSKVHYSECEKFPIKCPQNCNSPTFNCTIERGRIKYHIENECPFTVIQCKYREAGCMLEFPRSELSEHMKLIDHSKYMEATIDQHICKFEKSEKEYKKLELEYNRLKDDFKILQSELKVIRELKFNYQNKWVITNWSQKLQDYPKPKSIESPEFMVGNLKFKIQFYPNGGLSDESKDFLSIYLYKFDDQTPSKVQFSFELLNKDFTRNRKLASTNIFHTENKWGWRSFINNSLVTTQTGFVIQNSVTLNINIEILPEEKEAFTS
What is the function of this protein?
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
What are the official names of this protein?
TNF receptor-associated factor family protein DDB_G0272340.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE2_COPV6
Sequence: MEKLSEALDLLQEELLSLYEQNSQSLADQSRHWSLLRKEQVLLYYARGKGIMRIGMQPVPPQSVSQAKAKQAIEQSLYIDSLLHSKYANEPWTLCDTSRERLVAEPAYTFKKGGKQIDVRYGDSEENIVRYVLWLDIYYQDEFDTWEKAHGKLDHKGLSYMHGTQQVYYVDFEEEANKYSETGKYEILNQPTTIPTTSAAGTSGPELPGHSASGSGACSLTPRKGPSRRPGRRSSRFPRRSGGRGRLGRGGSGELPPQPQPSSSWSPPSPQQVGSKHQLRTTSSAGGRLGRLLQEAYDPPVLVLAGDPNSLKCIRYRLSHKHRGLYLGASTTWKWTSGGDGASKHDRGSARMLLAFLSDQQREDFMDRVTFPKSVRVFRGGLDEL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: KOSYN_HERA2
Sequence: MRPTPTLAEFLHAPLTTIRQVAPATMVFSSGGSRRKAALANMSAAGEEYARWSHQQLLKCLELFFSHGIKHLFLPMLLPNQFQETTPNYREHIEQWVAWGAASQTMLEYYQEHNWRVRLLDTQYSPILADAAQRLQQPYDHPDQPTLWWFVVRDSEDPWQIIFQAAQKTVFKTRSQAIEAIYGEPIPPAELFVSFGKPQVNHDLLPPLLVGELQCYWTQKPGYTLSEEEFRQILYDFAFLRKTWQVDKTERTQAALAFRQHWERGPILGLGQQLGPFWYPQSTSIESEL
What is the function of this protein?
Involved in the biosynthesis of (+)-O-methylkolavelool.  Catalyzes the biosynthesis of (+)-kolavelool from (+)-kolavenyl diphosphate via the release of the diphosphate moiety through the nucleophilic addition of a water molecule.
What are the official names of this protein?
(+)-kolavelool synthase.
What is the protein family that this protein belongs to?
Belongs to the diterpene synthase family.
Protein: PHNC_TREDE
Sequence: MILELKNISKTYPSGRRALQSISFKIEEGEILAIIGLSGAGKSTMLRCINRLVEPDEGEVIFLGEKINKLKGKKLRQYRSKIGMIFQNYNLVERLNAVENVLHGCLGSIPSYRGALGLYTEEEKEKAFALLQTVGMEEFAFQRCSELSGGQKQRIGIARALMQSPKLLLCDEPIASLDPQSSETVLNYIKEFAVNKNIACLISLHQMEAAKKYADRIIALNNGKIVFDGIPDSLNDEVLHKEIFTNVSIDSGEKSL
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TUS_KLEPO
Sequence: MASYDLVERLNNTFRQIELELQALQQALSDCRLLAGRVFELPAIGKDAEHDPLATIPVVQHIGKTALARALRHYSHLFIQQQSENRSSKAAVRLPGAICLQVTAAEQQDLLARIQHINALKATFEKIVTVDSGLPPTARFEWVHRHLPGLITLSAYRTLTPLVDPSTIRFGWANKHVIKNLTRDQVLMMLEKSLQAPRAVPPWTREQWQSKLEREYQDIAALPQRARLKIKRPVKVQPIARVWYAGEQKQVQYACPSPLIALMSGSRGVSVPDIGELLNYDADNVQYRYKPEAQSLRLLIPRLHLWLASE
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXA3_MOUSE
Sequence: MQKATYYDSSAIYGGYPYQAANGFAYNASQQPYAPSAALGTDGVEYHRPACSLQSPASAGGHPKTHELSEACLRTLSGPPSQPPGLGEPPLPPPPPQAAPPAPQPPQPPPQPPAPTPAAPPPPSSVSPPQSANSNPTPASTAKSPLLNSPTVGKQIFPWMKESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGAYGLPPASYPAPLPSCAPPPPPQKRYTAAGSGAGGTPDYDPHAHGLQGNGSYGTPHLQGSPVFVGGSYVEPMSNSGPLFGLTHLPHTTSAAMDYGGTGPLGSGHHHGPGPGEPHPTYTDLTAHHPSQGRIQEAPKLTHL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Binds 5' to its own homeobox.
What are the official names of this protein?
Homeobox protein Hox-A3, Homeobox protein Hox-1.5, Homeobox protein MO-10.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOC_BDEBA
Sequence: MRDLLNFFDKPKDPLSFDAVRVSLASPEMIREWSFGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRMKYRGVVCEKCGVEVTQTKVRRERLGHIELATPVAHIWFLRSLPSRIGNLLNLSLKDVEKVLYCEAHVVIDPMETTLEEGQVLTEEALQAALNEFGPSFKYGMGGEAVRDLLKKIDPEYLSRKLRLEVKDTKSEAGIKKLTKRLRVVEAFKGSINKPEWMMLEALPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLQELNAPDIIIRNEKRMLQEAVDALLDNGRRGKTFTGPNKRPLRSLSDMLKGKQGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFVYNKLEEKGLATTIKQAKRLVDQETVEVWDILADVVKEHPVLLNRAPTLHRLGIQAFEPVLHEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSVESQVEARVLMMSTNNILSPANGKPIINPSQDIVLGMYWLTRMRPGAKGSGKAFSSVQEAQYAFETGLVDLQAVCKVRINGTLQETTVGRAILSDIVPKEVPFNEVNVTMGKKQIAALIDKTFRLAGAKATCILADKIMEYGFKYSTAAGMSIGIDDMVIPAAKAPMIADAEKQVTEIQQQYDEGLITDGERYNKVVDIWAQTADKIAKEGMNAIEKQTFNVNGKEVVGPSFNPIYIMADSGARGSAAQIRQLGGMRGLMAKPSGEIIETPITANFREGLTVIQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDVVVSEIDCGVEDGLEITPIYEAGEIVQNIGDRILGRTALKDVVDAATNEVVVRANQEITENDVKIIEGRGIDKVDIRSALICQSKRGVCVKCYGRDLSRGATVNLGETVGIIAAQSIGEPGTQLTMRTFHLGGAASRAVEQSVHTSRYDGVVKLQNVHAVTNRNGKLTVMNRNGSALVIDEAGRERENFKLVYGAVLNFKEGDKVAKGQTVAEWDPYSNPIIAEVSAKIQYQDIEEGSTMQEQVDAVTGFATKVIMESKSSDVKPTVFLVDGAGKTLNLPGRDIPARYLIPVGAQLLVADQQEVHAGDVIAKMHREASKTKDITGGLPRVAELFEARKPKEAAIISEIDGYVTFGKDVKGKQRVIVTPEVGEQKEYLIPKGKHVAVREGEYVRAGEALMDGPTNPHDILAVLGAKALSAYLVDEIQEVYRLQGVGINDKHIEVIVRQMLRKVEIRDAGDSRFLAGEQVERYAYMEENERINKEGGQPATCSPLLLGITKVSLSTDSWISAASFQETTKVLTEAAINSRTDHLRGLKENIIMGRLIPAGTGLTSYKRWKVSVHEDDDIGFVALPGMTSSVQPQG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.