PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_PETMO
Sequence: MEELTKRQSQVLDFIKSYMEKNGFAPSIRDIMKHFNFKSPRAAHKHLIILEKKGYIERKNVSRGIKMMPKSGEIFATETLAPVSGKIAAGDAIEAIQTISDYIPIPTNFFPKNYEYFSLRVEGNSMIEAQIKSGDFVLIRKQDYAMDGDIVVALIDGNDATLKRYKRLNEDEVLLIPENKSMKEIKVKADHLKIQGKMVGLIRVL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: TUSB_SALEP
Sequence: MLHTLPHCASSVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTDFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_RHILO
Sequence: MGLNDSSGTLVAPKPKGIIDPNTGRPVGEDDPFFLEINNELADKGFLVTSTEALITWARSGSLMFMTFGLACCAVEMIHTSMPRYDSERFGVAPRASPRQSDIMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPSAEALLYGILLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RECA_SYNAS
Sequence: MGTDGDRAKAVDLAISQIERQFGKGSIMRLGAKERIEDIAVIPTGALSLDIALGIGGVPRGRIIEIFGPESGGKTTLALHIIAEAQKRNGLAAFIDAEHALDVSYARKIGVNTDDLLISQPDTGEQALEIAETLVRSGALDILVVDSVAALVPKAEIEGEMGDAQMGLQARLMSQALRKLTGSISKSNTTVIFINQLRMKIGVFFGNPETTTGGNALKFYASMRLDIRKSGSIKSGQDVIGMRTKVKVVKNKVAPPFRETEFDILFGEGISKAGDILDLAAESGIVEKSGAWYSYGGERIGQGRDNTRNFLKEHPDILVRIEEQVRSEHGLKPRLQEQEEPAK
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_CYAM1
Sequence: MCMSQFPIEFQIECAASTINHARDIYAKFILQPLSYTQALTMGNSLRRVLLSELESISITAVRIAGASHELATLKGVREDVLQIMLNLKQIVWRGQLKKQPTITRLKVQGPAIVTAAAFQSEANSSANIIDTCQYIATIDTQDILEMECQLEQSSGYRLAKPSEMIDWLPIDGVFMPVKRVNFWVDKALVDKVLVDKALHLEIWTNGSISPQEALHQAARILTHWFNPLQTLEWKTSHTKNEQTMAQLSNMLIEELDLSVRAYNCLKRAQIHSVADLMQYTQEELLALKNFGQKSVEEVNKALEQKLHCQLKKYVD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NRDR_SYNJB
Sequence: MKCPRCSKQEIRVLESRSAEGGQSVRRRRECMSCGYRFTTYERIEFMPIMVIKRDGSRESFNRNKILQGVMRACQKTPVTVRQMEELVNEIEEKLQLEDAQEVTSLRIGEMVLERLQHLSEVAYVRFASVYRQFQGIKDFVNELEQLEPPLRRDLERLLQDSSASDSESSGSPDLVGEYS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: YZGL_ECOLI
Sequence: MQNRKWILTSLVMTFFGIPILAQFLAVVIAMLGVGLAGIIEVCNILITPTIYLLLKIFMLALGALMLFFSGRVGNVPEFCYVGYDGVGFAVIP
What are the official names of this protein?
Protein YzgL.
Protein: RL19_THENN
Sequence: MSMDHLVRIIEKKYEKKEIPDFRPGDTVRVHVKVIEGDRERTQVFEGIVIAKRGSGINRTFTVRRIGSHGVGVERIFPFHSPVVEKIEVVRKGKVRRAKLYYLRDVKGKIRIKERRD
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: HEM6_SHIDS
Sequence: MKPDAHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQRESGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDDYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYAERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASAT1_ARATH
Sequence: MASFIKAWGLVIISLCYTFFIAKLVPKGIKRLILFFPVFLIFFIVPFLIYSLHLLGITAFFIAWLANFKLLLFALGRGPLSSNHKPLSLPIFLAVSCLPIKIQLSPKPTKTHSHEGSTEGPLIYTIKAVFVVLIIKAYEYSTKLPEKVVLTLYAIHIYFALEIILAATAAAVRAMSDLELEPQFNKPYLATSLQDFWGRRWNLMVTGILRPTVYEPSLQLFSVLGPNYSQILAAFGTFVVSGIMHELIFFYMGRLRPDWKMMWFFLINGFCTTVEIAIKKTINGRWRFPKAISQVLTLTFVMVTALWLFLPEFNRCNIVEKALDEYAAIGAFAVEVRRKLTAYLF
What is the function of this protein?
Involved in the esterification of cycloartenol.  Not implicated in the formation of sterol esters in flowers or during seed maturation.  Has a substrate preference toward saturated fatty acyl donors (16:0 > 18:0 > 16:1 > 18:1).  Does not require triacyglycerols (TAGs) as a fatty acyl donor, and is unable to acylate diacylglycerol to produce TAG.
What are the official names of this protein?
Acyl-CoA--sterol O-acyltransferase 1, Sterol O-acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the wax synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LPAR4_HUMAN
Sequence: MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNNGGELMLESTF
What is the function of this protein?
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.  Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity.  The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
What are the official names of this protein?
Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHE3_YEAS6
Sequence: MSDQDNTQTSSSKLAPHHNIFMANLESSPTKDRNTSSQNASSSRVIESLHDQIDMLTKTNLQLTTQSQNLLSKLELAQSKESKLLENLNLLKNENENLNSIFERKNKKLKELEKDYSELSNRYNEQKEKMDQLSKLAKKSSAIEQSCSEKLQNMEVNYNSLLESQNLYRDHYSDEISKLNEKIGLLELELSNQNLNYGSDTSSNSDIELNLNKFNDSVKDLKSLETEKDSKLSKIITHSLDELNLQSWLNLYQTNENLISTFAEKMDLKDVLKRNDEKISNKGAVVQTLKKNVQTQVESNNADALSSNNAQDMLPIKMVKLRKTPNTNDSSSNGNSSNNKRRSFYTASPLLSSGSIPKSASPVLPGVKRTASVRKPSSSSSKTNVTHNNDPSTSPTISVPPGVTRTVSSTHKKKRNSMVVHGAQS
What is the function of this protein?
RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease.  Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell.  Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity).
What are the official names of this protein?
SWI5-dependent HO expression protein 3.
What is the protein family that this protein belongs to?
Belongs to the SHE3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RSMH_ANAPZ
Sequence: MDSHRPVLLNEMLELLSPKDGAVYVDATFGGGGYSRGILERAKCTVLAIDQDPIASEFYQSLHSQFPGRVHFFLSKFSRLREALQHFDHNQVDGVVFDVGVSSMQLSDPDRGFSFMKEGPLDMRMDMLRSQSKSAATFVNSLSEKDMADVIFYYGGERLSRRVTRAIISARESNNKIRNTSDLAKIIRSVVPRSKANPIDPATRTFQAIRIWVNDELEELKAGLEAASQIVGVGGKIIVTSFHSLEDRIVKHKFNALREKGFQLINKKAIKPTEKEISENTRSRSAKLRGIVKEE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y329_RICTY
Sequence: MKQNTYSPLVSIIIPVYNGANYMREAIDSALAQTYKNIEIIVVNDGSKDKTETIALSYGDKICYFYKENGGCGSALNYGIKNMKGEYFSWLSHDDLYYPNKIEHQINILNKLDNKDVIVYCGYELIDQKSHSLYFVKPDQRYSKEKLDISLFPLLHSLIHGCTLLIPSILFKKIGLFDESLKYTHDYDLWFKFLRVSSVYFDHEVLIKSRVHDAQTTNTALNQLEEYEALWSGFLKKLTKQEMIMIKGSTHQFLSDIAVFFKKNGYIKSYQLALAMTDKKIIGGFCTFIIKEIIYSLRKYGINTTITKIYTWIRKNRK
What are the official names of this protein?
Uncharacterized glycosyltransferase RT0329.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: SURE_LEPBJ
Sequence: MNILITNDDGIASSGIKALEAVLQKEHDTFLIAPLRERSATSMALSIYDSMRVERINDNHYIVDGYPADCVNIGLHGDIFPRIDLVLSGINRGVNMGHDIHYSGTVGAARHGAVHSRLSLAVSSGNITKDYDYIREAEFVRHFIDEYSSLLKVGVVYNMNIPFDFVSSMENLRITRLGKRTYEDTYSKKNIIGGIADFYLGGSKLEHATEEGTDFTAFFSGKISLTPLSLDQTDISLVQELSDTLSKSLS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_XYLFM
Sequence: MENNPSSKIEVAVSSRFLDQQSNRNEGRYVFAYTIRIYNAGNVPARLIARHWQITDANGKVEYVTGEGVIGEQPRLRPGEEFRYTSGVVLGTEQGQMQGHYDMMADDGTEFTATISPFVLSVPRTLH
What are the official names of this protein?
Protein ApaG.
Protein: PI42C_XENLA
Sequence: MSSSGAMPAVSSTSSSAAVGILSATTAKTKTKKKHFVQQKVKVFRASDPLISVLMWGVNHSVNELIQVPVPVMLLPDDFKANSKIKVTNHLFNRENLPSHFKFKDYCPQVFRNLRERFGIDDQDFQVSLTRSSPYCESEGHDGRFLLSYDKTLVIKEISSEDVADMHIILSHYHQHIVKCHESTLLPQFLGMYRLSVDNEDSYIIVMRNMFSHRLTVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKSQKVYVDEEQKRNFMEKLKRDVDFLVQLKLMDYSLLLGIHEVFRAEQEEEEELEEDNAENECSPHVNVGSYGTSPEGIAGYLNSHKPLGPGEFEPIIDVYAIKSSDNAPQKEVYFMGLIDILTHYDAKKKAAHAAKTVKHGAGAEISTVHPDQYGKRFLEFVTNIFA
What is the function of this protein?
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity.  May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Cytoplasm.
Protein: B3GN4_HUMAN
Sequence: MLPPQPSAAHQGRGGRSGLLPKGPAMLCRLCWLVSYSLAVLLLGCLLFLRKAAKPAGDPTAHQPFWAPPTPRHSRCPPNHTVSSASLSLPSRHRLFLTYRHCRNFSILLEPSGCSKDTFLLLAIKSQPGHVERRAAIRSTWGRVGGWARGRQLKLVFLLGVAGSAPPAQLLAYESREFDDILQWDFTEDFFNLTLKELHLQRWVVAACPQAHFMLKGDDDVFVHVPNVLEFLDGWDPAQDLLVGDVIRQALPNRNTKVKYFIPPSMYRATHYPPYAGGGGYVMSRATVRRLQAIMEDAELFPIDDVFVGMCLRRLGLSPMHHAGFKTFGIRRPLDPLDPCLYRGLLLVHRLSPLEMWTMWALVTDEGLKCAAGPIPQR
What is the function of this protein?
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine.  Has activity for type 2 oligosaccharides.
What are the official names of this protein?
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4, BGnT-4, Beta-1,3-Gn-T4, Beta-1,3-N-acetylglucosaminyltransferase 4, Beta3Gn-T4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: HPND_SINFN
Sequence: MRAEAAAHANHRSTALGSSFYLGMRTLPPVQREAIFQIYSFCRQVDDIADSDEPREHRLAALQQWRDHIDALYQCVPPPRLKDYLASVTTFGLKREDFLAVVDGMEMDVLQDIRAPKMATLDLYCDRVASAVGRMSVRVFGLSEEDGIALAHHLGRALQLTNILRDIDEDAGLGRLYIPRESLDHAGITSSDPHKVIADKALPKACAPLAQRAMMHFAESDEIMNCNPRRIVRAPTIMSKCYRAILDLLLIRGFAAPREPVRVTNLTKRAILFRYALML
What is the function of this protein?
Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP).  Catalyzes the first step, the formation of presqualene diphosphate (PSPP) from two molecules of FPP.
What are the official names of this protein?
Presqualene diphosphate synthase, PSPP synthase, PSPPase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family. HpnD subfamily.
Protein: PMP22_RAT
Sequence: MLLLLLGILFLHIAVLVLLFVSTIVSQWLVGNGHRTDLWQNCTTSALGAVQHCYSSSVSEWLQSVQATMILSVIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAAAIYTVRHSEWHVNNDYSYGFAYILAWVAFPLALLSGIIYVILRKRE
What is the function of this protein?
Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
What are the official names of this protein?
Peripheral myelin protein 22, PMP-22, Protein CD25, SR13 myelin protein, Schwann cell membrane glycoprotein, SAG.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CEP55_HUMAN
Sequence: MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
What is the function of this protein?
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893).  Recruits PDCD6IP and TSG101 to midbody during cytokinesis.  Required for successful completion of cytokinesis (PubMed:17853893).  Not required for microtubule nucleation (PubMed:16198290).  Plays a role in the development of the brain and kidney (PubMed:28264986).
What are the official names of this protein?
Centrosomal protein of 55 kDa, Cep55, Up-regulated in colon cancer 6.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.
Protein: NXF5_HUMAN
Sequence: MRRNTQDENMRKWFKVTIPYGIKYDKAWLMNSIQSNCSVPFTPVDFHYIRNRACFFVQVASAASALKDVSYKIYDDENQKICIFVSHFTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKITERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQSNLCKYFKDSRNIKILKDPYLQRKLLKHTKCPRNVDSLSALPETQHDFTSILVDMWYQTVNTCFLPRAGPESQRWWCLLSLKWKDGLRVLILPSCGPSSLPLAAIPVCAS
What is the function of this protein?
Could be involved in the export of mRNA from the nucleus to the cytoplasm.  Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
What are the official names of this protein?
Nuclear RNA export factor 5, TAP-like protein 1, TAPL-1.
What is the protein family that this protein belongs to?
Belongs to the NXF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Protein: IL2_MACFA
Sequence: MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELRHLQCLEEELKPLEEVLNLAQSKSFHLRDTKDLISNINVIVLELKGSETTLMCEYADETATIVEFLNRWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_RICTY
Sequence: MKMVSDINALKYKKVLLKVSGEALMGNKQFGHEYEVIKKIAEDIKEVIDLGLEVAIVVGGGNIYRGINAALVGMDRASADYIGMLATVINALTLQNVMESLGIYTRVLSAIPMMSVCEPYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIEMNCDILLKATQVDGVYDSDPKKNPNAKKYFTISYKDVITNHLQVMDTAAIAVARENKLPIRVFSIKEHGNIARVIQNKGKYTTIEE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNM3B_MOUSE
Sequence: MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
What is the function of this protein?
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development.  DNA methylation is coordinated with methylation of histones.  May preferentially methylates nucleosomal DNA within the nucleosome core region.  May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation.  Seems to be involved in gene silencing.  In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.  Functions as a transcriptional corepressor by associating with ZHX1 (By similarity).  Required for DUX4 silencing in somatic cells (By similarity).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase MmuIIIB, DNA MTase MmuIIIB, M.MmuIIIB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Protein: HPRK_STAAR
Sequence: MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.