PharMolix/UniProtQA huggingface dataset:
Protein: LEU3_YERPE
Sequence: MTKTYHIAVLPGDGIGPEVMAQASKVLDAVRQRFGLKISTSVYDVGGAAIDRHGSPLPAATVAGCEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEDFCPLRSDIAARGFDILCVRELTGGIYFGQPKGREGQGMHERAFDTEVYHRFEIERIARIAFESARKRRSKVTSIDKANVLQSSILWREVVNGIAADYPDVALSHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLTLLLRFSLGKDDAADAIERAINQALEQGYRTADLAGDGHAIGTHEMGDIIAKFVVEGV
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G11A_ORYSI
Sequence: MASKAMPRAPPAAPNLQSLKLCSQNDSSLETTSPSKRSALVPGRSAESSKPNSEVVQKEQKSTQHQNESIDLTGSNDPAEVKAEGNLVPKRLADEEKGVVEDGIANGSLKSSSALGKEHGIASASGSARLVGRSETGERGFSSSRCRPSTSSDVSDESACSSISSVTKPHKANDSRWEAIQMIRTRDGILGLSHFKLLKKLGCGDIGSVYLSELNGTKSYFAMKVMDKASLASRKKLLRAQTEKEILQCLDHPFLPTLYTHFETDKFSCLVMEFCPGGDLHTLRQRQRGKYFPEQAVKFYVAEILLAMEYLHMLGIIYRDLKPENVLVREDGHIMLSDFDLSLRCAVSPTLIRSSNPDAEALRKNNQAYCVQPACVEPSCMIQPSCATPTTCFGPRFFSKSKKDRKPKPEVVNQVSPWPELIAEPSDARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVIGQPLRFPEYPVVSFSARDLIRGLLVKEPQQRLGCKRGATEIKQHPFFEGVNWALIRCASPPEVPRPVEIERPPKQPVSTSEPAAAPSDAAQKSSDSYLEFDFF
What is the function of this protein?
May play a role in the regulation of metabolism and signal transduction processes.
What are the official names of this protein?
Protein kinase G11A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CYB_OVIDA
Sequence: MTNIRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTPDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFMIAALAMVHLLFLHETGSNNPTGIPSDTDKIPFHPYYTIKDILGAILLILVLMLLVLFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLVIMPLLHTSKQRSMMFRPISQCMFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLIILVMMPVASIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: URE1_PSYIN
Sequence: MATIDKHSYAHMFGPTVGDRVRLADTDLWLEVEKDYTQYGEEVKFGGGKVIRDGMGQSQASCFDTVDLVITNALIVDHWGIIKADVGIKEGRIAIIGKAGNPDIQDNIDIEIGPGTEVIAGEGKILTAGGIDAHIHFICPQQIEEAQMSGVTTMIGGGTGPATGTNATTCTSGPWNIHKMLQATNDFAMNFGFLGKGNTSLPLALEEQIEAGVCGLKLHEDWGTTPASIDNCLAVAERYDVQVAIHTDTLNEAGFVEDTMAAFKGRTIHTYHTEGAGGGHSPDIIRACGEPNVLPSSTNPTRPYTVNTIDEHLDMLMVCHHLDPSIPEDVAFADSRIRKESIAAEDIMHDLGAISMIASDSQAMGRVGEMITRTWQTANKMKQQRGPLAPDTERNDNFRIKRYIAKYTINPAISHGISHEVGSIEVGKLADLVLWKPAFFGIKPAMILKSGFIAAAPMGDANASIPTPQPVYYRPMFGSFGSAAAKTSMTFLSQAAIDQGVPEKIGMTRMVGVCKNTRNIGKKDMIHNNWQPKIEVDAQTYEVRADGELLTCEPATELPLTQRYCLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_RHIL3
Sequence: MAMLSDTIYALSSGAPPSGVSVVRVSGPLTRDILVKLVGSVPAARHVSHRTIRTRNNQPIDSGLVLFFPAPNSFTGEDVAELQIHGSRAVLAALFHALGDIPGVRMAVEGEFSRRAFENGKLDLVEVEGLADLIGAETEMQRRLAVEHSAGGLSAIYDSWAERLTRARALVEAELDFPEEDDVPGSVSDAVWADMAKLRSDIGDHLAAASAGEIIRDGFKVVIAGAPNAGKSSLLNALARRDVAIVTEIAGTTRDVLQVDLDIDGYLIKLFDTAGLREADDKVEMEGVRRARVALRDADLVLLLVDMTKPLIPDDLEQSSPHVTVGTKKDLTEVNSGRYDLQISTATGDGLPELRRLIGDIVERRFAGLSMAIPSRQRHKDSLAKCLAALDVALSQTDVNLELRTEQLRIAAEYLGRITGRVDVEQLLGVIFSEFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E4PD_ECOSE
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBOA6_DROME
Sequence: MLEPPKFIENDCYNGSRTFTWLADMVGLSVDLVNFLICQISALFLASLFRSMLHPSKVSSKLRHTFALSIGLAFGYFCFGQQAIHIAGLPAICYIVIRTQDPRIVQRAVLLVAMSYLLCVHLMRQLYDYGSYALDITGPLMIITQKVTSLAFSIHDGFVRGDEELTKAQQYHAIRKMPSALEYFSYVWHFQSILAGPLVFYKDYIEFVEGYNLLSTPPGNGNLDSSKREVVLEPSPTKAVIRKVVGSLVCAFIFMKFVKIYPVKDMKEDDFMNNTSMVYKYWYAMMATTCIRFKYYHAWLLADAICNNSGLGFTGYDKDGNSKWDLISNINVLSFEFSTNMRDAINNWNCGTNRWLRTLVYERVPQQYGTLLTFALSAVWHGFYPGYYLTFATGAVVVTAARTGRRLFRHRFQSTQVTRMFYDILTCLITRVVLGYATFPFVLLEFMGSIKLYLRFYLCLHIISLVTIFILPKFIRGERRLRTSNGNGNVRLSGSGNTKDAVTTSVESTAALTAGNDLNEDKEEDKHAQCKVHTPTQQQPAAGPHKTTVEQPTEQPNNVNLRSRPQQQQPHLEKKAMPPTCARDAVSVPHDQCEMDQLSSKLKEKIEAETKNIEEFIDKTVTETVSGIVEFKNDLMRDIEFPKLKLPGSNGAISLDSSNGGGLRKRNISSVHDNGTDPGHATADLHPPLEENGAAFLKKEIEVINAVVQQAVPAVLSNGHAK
What is the function of this protein?
Acyltransferase with broad-specificity, that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids).  Converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), also lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphochethanolamine or LPE) to phosphatidylchethanolamine (LPEAT activity) and lysophosphatidylglycerol (1-acyl-2-hydroxy-sn-glycero-3-phospho-(1'-sn-glycerol) or LPG) to phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) or PG) (LPGAT activity).  Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA).  Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature.  Essential for fertility and viability together with Nessy protein (Nes).
What are the official names of this protein?
Lysophospholipid acyltransferase 6, LPLAT 6, Membrane-bound acyltransferase 6, MBOA 6, Oysgedart, Oys.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Protein: ALR_DESDA
Sequence: MVSFDRPVWAEIDLSAFRHNMRQIKSLLQPGTIFCPIIKADGYGHGAVPLAHEAVAMGAGYLGVAILDEAAALRAAGITLPILILGYTPPQAAAFVVSNHITQTIFSKEQADALSAAASNLGITVKVHVKVDTGMTRIGVRPEEAAAFCSYVAGLENVHLEGMFTHFASSDSADHAYCLEQFGRFTAAIAAVEASGIRLGIRHCANSAAILSLPEGHLDMVRAGIILYGLKPSDECPMPIDLRPVMRLKARLAMVKQVPPGVGVSYGSIYHTQKESSLATIPIGYADGYTRMLSRKAQVLLRGQRAPVVGRICMDQCMVDVSHVPQAAVGDEVLLFGGPDLPADEIAAHLGTINYEVVCMVGKRVPRVYVE
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: UBC13_SCHPO
Sequence: MALPKRIIKEIETLTRDPPPGIVAAPTEDNLRYFKITMEGPQQSAYEGGKFHLELFLPDEYPMMPPNVRFLTKIYHPNVDKLGRICLSTLKKDWSPALQIRTVLLSIQALMGAPNPDDPLDNDVAKIWKENEPQAIANAREWTKKYAV
What is the function of this protein?
Has a role in the DNA error-free postreplication repair (PRR) pathway.  The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 13, E2 ubiquitin-conjugating enzyme 13, Ubiquitin carrier protein 13, Ubiquitin-protein ligase 13.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: BPPAD_BOTCO
Sequence: QNWPHPPMPP
What is the function of this protein?
This peptide evokes slight hypotension (-2 mmHg), when injected alone into rats.  It has no bradykinin-potentiating effect, when 60 nmol of BPP-10d are coinjected with 0. 5 ug of bradykinin into rats.  It inhibits angiotensin converting enzyme (ACE) activity with a K(i)app of 9. 12 uM.
What are the official names of this protein?
Bradykinin-potentiating peptide 10d, BPP-10d.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: AMP_ONYPE
Sequence: MQNQKNQKSLVAKVLVLFAAVALMFVGVQVFADDKLDLNTLECKDALELTAADAADAEKVVKQWKVQNTSLNAKVTKDSVKVAVADNKVTVTPADGDAGKALSGSKILNLVGVCELNKLTLGTEKKLTLTVKDGKVDAEAGLKALKEAGAKVPATVNKDDVTFTVGKDDNANKVTVKAVDGKTTVSGQVVFEFTVAKTPWYKTVWFLTLVAVVVVAAVAGGVFFFVKKNKKNK
What are the official names of this protein?
Antigenic membrane protein, Immunodominant membrane protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GCNA_DANRE
Sequence: MDPGTLSLFQRVSTKLGWDRDGGLDDAEEKLRKSLKKTRRPALASSDSSTGPAQRLELSDSDNSSGKENRSQEEHILLTSDDEDFEKFLASKATPKSTFKQSASSAQKPREPVPVLSSESDNEFELFLNRVKTPKAKVQPQSMSSSDESLKHFIVDSMSSDDDFVTEKKPSIYKGKAKTVKTPKSVQKTKKPAPSLCNSPVFLSDSDDDCNIVIKSTWRTRHSRPPSDEHQATSKDREETEKPRVPQPTITVKSHTSRDDTCSSEEEFQSLLDRVRQNLGGRTSASPMPSAEPKPQRPCLSTPSATGRKTGSQVPVKDSPVIHTPVQQMPSSRPVLSHTEPRALPNSRVVVCKTPGCFLQSLSAPGSVYCRSFKQNKDELTSKLYQLYNTSVFDSQLPVDMSVTWNNKMRKTAGYCISGQERGTGKRYARIELSVKVCDSADRLRDTLIHEMCHAATWLINNVRDGHGPFWRLYARKAMLAHPELPMVSRCHSYDINYKFQYQCNRCKNTIGRHSKSLDTTKFVCALCTGQLVLLTPSKPRAPTPFATFVKENYGSTKQELTGQSHAEIMRKLSADFASKTRLSQS
What is the function of this protein?
May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage.
What are the official names of this protein?
Germ cell nuclear acidic protein, Acidic repeat-containing protein, Germ cell nuclear acidic peptidase.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Chromosome. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (By similarity). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity).
Protein: KHSE_THEVB
Sequence: MITVVTVPATTANLGPGFDCLGAALTLTNRFTFSLSDRPHVSVRGPEAAAVSSGPNNLAYRAYSRFYEYLGREAPPVYLEIDLRVPLARGLGSSATAIIGGLVGANRLAGFPLSHTEVLELAIEMEGHPDNVVPALLGGCRLAVQEDAGGWHWLEIPWDQDVVPILAIPDFELATETAREVLPPHCAYGDAIFNISHLGALLRGLETGQREWLQLALADRLHQPYRQSLIKGYPDLHRAALEAGAHGLVISGAGPTLLALGDPVTASAIATALKETWAKFDVQAQVEILAIQHQGTTVCDR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_HISS2
Sequence: MPELPEVETTLKGVSPYLKGFIIEKIVVRNPKLRWEVSKELSTFKHVKILNLTRRAKYLIIHTEQGYIIGHLGMSGSVRIVPHDNPVNKHDHFDIVMNNGKLLRYNDARRFGAWLWTNNLSEFHLFFKLGPEPLSETFNSTYLFKKSRQKSTALKTFLMDNSVVVGVGNIYANEILFLCGLHPQKIAKTLTKKQTEQLVFTIKQVLNEAIEQGGTTLKDFLQPDGRPGYFAQKLLVYGNKDKPCPRCGTKIKSIIIGQRNSFFCPQCQKK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DADA_ECO8A
Sequence: MRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYENATRDIAVLEDAGVPYQLLESSRLAEVEPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPVDQLLCDGEQIYGVKCGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGRTRFKNLWLNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPSRPGHLHGAHS
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: LRC28_HUMAN
Sequence: MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKDLNFLSPISLPRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQWKTTVSFVAYCCSTQCLQTFDLLS
What are the official names of this protein?
Leucine-rich repeat-containing protein 28.
Protein: PRAF2_BOVIN
Sequence: MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS
What is the function of this protein?
May be involved in ER/Golgi transport and vesicular traffic.  Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).
What are the official names of this protein?
PRA1 family protein 2.
What is the protein family that this protein belongs to?
Belongs to the PRA1 family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein.
Protein: YNCL_ECOLI
Sequence: MNVSSRTVVLINFFAAVGLFTLISMRFGWFI
What are the official names of this protein?
Uncharacterized protein YncL.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GLI3_PANTR
Sequence: MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITMQPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHRNPAAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALLGDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALPRVPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTMDADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSTLPDDSKVPHGPGDFDAPGLPDSHAGQQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVHPQNPLRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQGYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNLQNYSGQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSLDSHDLEGVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSYSSSRLTTPRASLPFPALSMSTTNMAIGDMSSLLTSLAEESKFLAVMQ
What is the function of this protein?
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development.  The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor.  A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity.  In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation.  Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.  Plays a role in limb and brain development (By similarity).
What are the official names of this protein?
Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3-190, GLI3 full-length protein, GLI3FL.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity).
Protein: KAX88_ORTSC
Sequence: MCRLYAIILIVLVMNVIMTIIPDSKVEVVSCEDCPEHCSTQKARAKCDNDKCVCEPI
What is the function of this protein?
Selectively inhibits voltage-gated potassium channels rKv1. 2/KCNA2 (IC(50)=331 nM) and hKv1. 3/KCNA3 (IC(50)=503 nM).  Partially inihibts rKv1. 6/KCNA6 (IC(50)=9983 nM).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 8.8, OSK3.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 08 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HACD2_MOUSE
Sequence: MAAAAATAATKGNGGGSGRVGAGDSSGARKKKGPGPVATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIERPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYIIKWARYTLFIVLYPMGVTGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYHAFLILIMISYIPLFPQLYFHMIHQRRKVLSHTEEHKKFE
What is the function of this protein?
Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction).  This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle.  This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation.  Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2, 3-hydroxyacyl-CoA dehydratase 2, HACD2, Protein-tyrosine phosphatase-like member B.
What is the protein family that this protein belongs to?
Belongs to the very long-chain fatty acids dehydratase HACD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RIMM_XANOR
Sequence: MKQTERRILLGRVVGAFGVKGELKLESWTEPRSAIFRYQPWIVRAPSGQESVINGVRGRDQGKNLIAVFPGVADRDTVEAMHGTEIYVARSALPPPKPDEYYWVDLEELQVETVEGVKLGTVSHLFSTGSNDVVVVRGDRERMIPFVFPDFVKSVDFEANLIVVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_SULAC
Sequence: MSWSILELIRNNPEVLKENLKRRFIDTSTVDKAVELDKKWRQTLQEVERLRHEHNLISSQIPKAPKEQKSELINKAKELLKTLEDKEKELQKIEEERENLLLSLPNLVHDSVPIGPDESYSVPIRFWGKFKVYKDDVNEFLKQTNGHKVDYEVINWKPVGHADMLENVLRLGDTKKAGEVAASRFYYLFNDIVWLDLALLLYAIDTITSRGYTLVLPPYMLRGEVIKSVIDLDTFKDAIYKIEGEDLYLIATAEHSIAALYYKEEIPKEELPLKLVGVSPAFRKEAGAANKDLKGIFRVHQFHKVEQFIFSSPEDSWKYHEEMIENAEEIFRGLGLPYRVINIASGDLGAPAAKKYDLEVWMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKNNKKGYLHTLNSTAIASTRAITAILENFQKEDGVVEVPKVLRKYLETFSGAPKEYIYPKKKPNTTS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL4_MESAU
Sequence: MGLRPQLAAILLCLLACTGNWTLGCHHGALKEIIHILNQVTEKGTPCTEMVVPDALSARKNSTEKDLICRASQGFRKFYFQHEVTLCLKNNSRVLKDLKKLYRGISSLFPQKSCNVNESTYTTLKDFLESLRRIMQKKYWQCGSSTF
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.