PharMolix/UniProtQA huggingface dataset:
Protein: YB12B_YEAST
Sequence: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNAFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSLKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKDSRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSNDLNIESDHDFQSDIELYPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTDSGGMHRLDVPLLAPMSQSNTHESSYASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRFTSDRILPSSESNSLHHVVPIKTSDTCFKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNSNKRIIAKLKMQYDTKIINLGESDDEIQHDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPNGRKLGAPGQPGLYINQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-BR Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: OBG_SALHS
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COCE_RHOSM
Sequence: MVDGNYSVASNVMVPMRDGVRLAVDLYRPDADGPVPVLLVRNPYDKFDVFAWSTQSTNWLEFVRDGYAVVIQDTRGLFASEGEFVPHVDDEADAEDTLSWILEQAWCDGNVGMFGVSYLGVTQWQAAVSGVGGLKAIAPSMASADLYRAPWYGPGGALSVEALLGWSALIGTGLITSRSDARPEDAADFVQLAAILNDVAGAASVTPLAEQPLLGRLIPWVIDQVVDHPDNDESWQSISLFERLGGLATPALITAGWYDGFVGESLRTFVAVKDNADARLVVGPWSHSNLTGRNADRKFGIAATYPIQEATTMHKAFFDRHLRGETDALAGVPKVRLFVMGIDEWRDETDWPLPDTAYTPFYLGGSGAANTSTGGGTLSTSISGTESADTYLYDPADPVPSLGGTLLFHNGDNGPADQRPIHDRDDVLCYSTEVLTDPVEVTGTVSARLFVSSSAVDTDFTAKLVDVFPDGRAIALCDGIVRMRYRETLVNPTLIEAGEIYEVAIDMLATSNVFLPGHRIMVQVSSSNFPKYDRNSNTGGVIAREQLEEMCTAVNRIHRGPEHPSHIVLPIIKR
What is the function of this protein?
Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants.  Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol.  Is able to prevent cocaine-induced convulsions and lethality in rat.
What are the official names of this protein?
Cocaine esterase.
What is the protein family that this protein belongs to?
Belongs to the CocE/NonD hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETS5_CAEEL
Sequence: MQYASALSRIPSSNSTSASKGPMAIALSATGTGQIQLWQFLLELLADAVNAHCIAWEGSNGEFKLVDPDEVARKWGERKSKPNMNYDKLSRALRYYYDKNIMTKVQGKRYAYKFDFQGLAQACQSAILTNGGNPNGDLSSTVHSLSPYTNQVLPIGVTSRLSTSMSSYHSILSSTSSTSSNQIIPPSTATYWSTPQSSLTYTGMPSSY
What is the function of this protein?
Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons (PubMed:21954162, PubMed:22479504, PubMed:30890567).  The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels (PubMed:21954162, PubMed:22479504, PubMed:28193866).  Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons (PubMed:21954162).  Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons (PubMed:22479504).  May mediate transcriptional activation by binding to the motif 5'-ACTTCCG-3' (PubMed:22479504, PubMed:30890567).  Acts in the BAG and ASG neurons to regulate intestinal fat levels and to promote exploratory behavior, possibly by regulating neuropeptidergic signaling (PubMed:28193866).
What are the official names of this protein?
ETS domain-containing transcription factor ets-5.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_RICAH
Sequence: MVKLKVRKGDEVIVITGKHKGKKGKILKVFPEDSKVIVAGVNLVKKHTKPNQMSGGGIITKELPIHISNIAHIDPKTGDPTKVAFKCLDDGSKVRVAKKSGEIIGKVGK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: AROA_BLOPB
Sequence: MNDFIKLAPIKKIQGTIHLPGSKSISNRALLLAAQATGTTQLTNLLDSDDVRCMLDALRNLGVSYCLSNNRKTCEINGIGGPIQSKNNNQLILSLGNAGTVMRPLIAALSVQTQNIVLTGHPRMKDRPIAHLVDALRQGGARIEYMERNGYPPIRLYGGYYGGEIFIKGSISSQFLSSVLMMTPLAYRDTLIKVDGALVSRPYIDITLSLMKIFGINIQHDNYRVFYCKGNMAYQSPGDYLVEGDASSASYFLAASAIRGGTVRVIGVGRNSKQGDIYFANILESMGAKIAWGDNYIECTRGADLNAVDLDVNNIPDAAMTLAITALFSINGPTILRNIYNWRVKESDRLAAMATELRKIGAEIVEGYDYLQITPPFKIESAYINTYDDHRIAMCFSLVALSDVSIIINNPKCTDKTFPDFFTQLSSISVLQ
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDIA3_MOUSE
Sequence: MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
What is the function of this protein?
Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (By similarity).  Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity).  Association with calcitriol does not affect its enzymatic activity (By similarity).
What are the official names of this protein?
Protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, ER protein 57, ERp57, Endoplasmic reticulum resident protein 60, ER protein 60, ERp60.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.
Protein: DAPAT_CHLTR
Sequence: MKRNPHFVSLTKNYLFADLQKRVAQFRLENPQHTVINLSIGDTTQPLNASVAEAFASSIARLSSPTTCRGYGPDFGLPALRQKLSEDFYRGFVDAKEIFISDGAKVDLFRLLSFFGPNQTVAIQDPSYPAYLDIARLTGAKEIIALPCLQENAFFPEFPEDTHIDILCLCSPNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIPDARFCAIEINSFSKPLGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPAQEAGVAGLSILPQLEAIHYYRENSDLLRKALLATGFEVFGGEHAPYLWVKPTQANISDRDLFDFFLREYHIAITPGIGFGRSGSGFVRFSSLGKREDILAACERLQMAPALQS
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate (PubMed:17093042, PubMed:21722650).  Is also able to use meso-diaminopimelate, cystathionine, lysine or ornithine as substrates (PubMed:17093042).
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: RS14_PSYWF
Sequence: MAKKSMINRELKREKMVAKYAEKRAKLKAIIGDVNASDEERMEAILELQSLPRNSSPVRLRNRCGVTGRPHGYFRKFGLSRNILRERVMQGDVPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: KHPA_AQUAE
Sequence: MSALKDIVELTAKELVDNKDKVRVTEIEGEKTVVIELRVDPAELGKVIGKQGRIARALRTILTAIGRKIGKRVVLEILE
What is the function of this protein?
A probable RNA-binding protein.
What are the official names of this protein?
RNA-binding protein KhpA, KH-domain protein A.
What is the protein family that this protein belongs to?
Belongs to the KhpA RNA-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TU97_GEMSP
Sequence: MGFYMLLTVALLLTSLMNVEATPVNQAERSALEKSGLGNRIQPRYDNCGDAEADCYQSKCMDEETYDEECEASCNYVVANCI
What are the official names of this protein?
Turripeptide IX-07.
What are the subcellular locations of this protein?
Secreted.
Protein: GLOB2_DICDI
Sequence: MSNKAKIEVFPELESATGQMIIIDEQTKKCAILDSVLNYTQNNGRTSTKDADKLIAYIKENQLEPEWILETHIHADHLSGAHYLKGIYPNAKTAIGEGAKIVQKTFKTIYNLEHTFPTDGSQFDKLFTDDERFTIGSLQVRVISTPGHTPACVSYYIENDSVFVGDTMFMPDVGTARCDFPNGSAETLWTSMKKILELPETVKVYVCHDYPPQERGITFFTTIAEQRLSNKHIKDSVTKDEFIKMRTERDATLKAPQLLLPSIQVNIRAGELPPKEDNGISYIKIPLNYLKQ
What are the official names of this protein?
Glyoxylase B2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: ENGB_AQUAE
Sequence: MKVKFLGSFFEEFPPPDYPEVVFVGRSNVGKSSLLNMVVGSKVAKVSKTPGRTRAVNYFLLDKKLYLVDVPGYGYAKVGREEMEKWRKMMERYFKERKDNIKMAFLLIDAVAGVQPLDEQMIEWFEYYGIPFTVVITKIDKASQSEIAKTLKQVKRYVGDGAIVLSSAKEGKGKKELLSRILN
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RL10_RHOPS
Sequence: MERAAKKEAVESLNGLFQTTSVAVVAHYSGLTVAQMQKLRSQMKQAGASVKVSKNRLAKIALEGTDVVAIGSLLKGPTVIATSSDPVAAPKVAVEFAKANEKFVILGGSMGKTVLNVDGVKALASLPSLDELRGKLVGLLVAPATKIAQLTTAPAAKVARVVQAYASKSEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: KU70_KLULA
Sequence: MSFEQPDFLKSQLTQTRDDDKESDHKKWRRYEAHDGIVFCIQLTPTMYLSNPDLGGKIQLLEILDSLNDLMSQLVVVMPSTAVGCYIYNCSHPNAEDNVYELIPLRDVNYKNMKRVSDLLEDIEQDRILLKDEIPIADPNNPIELSPVLIKVRETFLQPIEGQKQLTNKKIFFFTDDDKPAEFLNVDSRSRLRKVVDDLYDYYINFVTFFIGSEDKPFDDSMYADILKWGSKINEAQSWLSSHGPSTNPINASYIKSKVKRTKEIKRIKFRCPLMLDERADLVVSVNGYTIVSHEIPGSKYKLVYANGSVRREAYSHREYLDAETGEAVDNSQLSKVYTFGDEIIELTEDENLKIQSGYSEHESFLKLIGFRSTEQCLHYYDNIDVPAFVVPNEEDYAGSIKTLASLYRTMLFKKKSAMVWGKLRPNSPPSMFVLTPSSKKDYNQGFYLYKVPFMEEVRKLPDFLNHSALIESDDYKVMSKVTETLINFFNLKNGYRPSDFHNPALQKHFKILREYLLQIEVDKSKPEDEGDETLQKVKQIYARIASSAKSDDVKQQRLVKYLKLWNSFYNRLSNLEVDTKPTKNKKAKLNL
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit Ku70.
What is the protein family that this protein belongs to?
Belongs to the ku70 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: CYAY_VIBCH
Sequence: MNETEFHQLVDSQLERIEAAIDEAGADIDYETSGNVMTLEFDDGSQIIINRQEPMREIWLASKSGGYHFKSIDGEWICSKTGLELLTLLKQECDKHADEPIDWV
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: RDRP_PMTVS
Sequence: MDQSILSKITSDDYVNAILHTSATRVGSDLHNAMCNVIVDQIKDSTEKNKKKKKIDVKRNLNEDQIQLLAELFPERRVVTSSVHRGTHSMAAAMRKIETDVIFTSFPKNGVIYDIGGNWATHAKRDDGGFVHCCCPILDFRDAQRKMTRLIDFNRFIDDAKVVSAEKAAVAAQIKKDCDLISENAKKDAYDANDLNGTWFCQNKFEDCVYDHSTLGDGKKEAYGMAIHSIYDIHLVDLVSAMERKKVRVLKGTFLFSADIIIGKKRGELPSVNGFYIIDGESIKYSFYDDPNCGYEHNLNSLMLYVTKTFVKAAGGAVYYLELTEMRGDTMFFTITDASEARVMGVLHDSSTKCLPLNKRDLVVFPLFDIDRATDELVFREELLSREFVNRALEYAFQLKDNQVTAEGLISYFASTNNAVVIGGSARKTSEKVDPKLLPMITTTLMVYQELQKAKQKRVLGKLKSKVKEELTLSGILESVVHRVFGRQSLYQRGLGVFAKWMQYSYGQDLVGIHDVPLYLEINDRIKLGSALKNVNGFSLSFSELDEKVSLYEEYERERQRISDEIVSEKIGLIGEGYVKVGESSLKPKQKVASRDGMAQWVSGECHLYNTMKCEEKPVEKPRRFSKVVLEEWISEGNCFALNNSFGDEVHWFDSLKEACGRAWRKQVSAVTFSDAEYFDNIENTENEELEEEEVIKTTEQVEQDWPIGNLPDVDPDDSASAQVCLTESASTSSDEDCDPMEQLIVAACERAFATKKFEEVTMDSQVVQSEEIEIVREGEHAHANLSSGESESSSQSQELVAVGSVPLSKWAQMVEDSEVRARQCAVDHDLSWDEVKYAKMPERPEEAEGDDFRTKAKREFLWYLKCKLVADKSTLVEIMRDFIYGQFHSGACETPKNACFLSYEKNVCGEWMFGKRYRHPSKGASSYAVRFTREDWKRAKLIKLQWKNAKAEENGEMSSDNSDKPIVPQGETGIYLFCDITFLMNEIPILNRLEISFKKRVQRRAPRITLVDGVPGCGKSTYVVKEANLVNQYVVTIGREAAEDLRERFKSERNATATQLKRVRTVDSYLLNDTQSRANVLHFDEALMAHAGMVYFCADDLSARSVICQGDSQQIPFINRVESITLRYSKLEIDNVVEKRLTYRSPLDVASYLTKKNFYGTSVVTSANPLVRSLKTVGPRDGMTSIYSIPKIPGTQYLTFLQSEKEEMRQYLGRGNWNVNTVHESQGKTYDNVVLCRLKATDNEIYPGGRNSSPYMVVGVTRHRRSLVYYTKAEDKLYFDLAEMLSVQEGKLMKHLHEEGVKXRQASKYEEIMVSDNAVTVPDVGNLVDLQEMYDIAFPGNSIVDTYFDGYEVATGGLQIDMNASLTYYPNRQMKMWKECRGMYPMLRTAMPEKRQSGLAEGLLALNKRNMAAPKLQESVNEFEVIESTIEKAKKVFFDESRIDNSKLETFEGAARWWVKQSCTAQKQMLADVRTLSEIDVTSYNFMIKGDVKPKLDLSPQSEYSALQTVVYPDKIVNALFGPIMKEINERIRVALKPHVIYNTRMTSDELDPAVEFLDVREDHESVEIDFSKFDKSKTSLHIRVVIELYKLFGLDEMIAYLWEKSQCQTTIKDRVNGIIAQILYQQESGNCDTYGSNTWSAALSLLESLPLEKATFMIFGGDDSLIFFPKGMVIEDPCRRLASMWNFDCKLFNFKNNSFCGKFLIKVGEKYKFAPDPYKLLTKLGRKDIKNSDLLSEIFTSIGDNYKSYDDYRVLEALNVAVMERYKLRCDVMFGLLALKKYINSFDLFASLFSHKGRYQRVEVGRNFEW
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).
What are the official names of this protein?
Replicase large subunit, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: CRCB_DEHM1
Sequence: MGEILLLAAGGALGAVSRYGLNNLTVKLLGDSFPYGTLIVNCLGCFVLGFLMQWGFSSDSHNTHLKLMLTAGFLGAFTTFSTFSYETLDCFKNGDYFNGFSNILANVLLGLLMVFIGAYLGSLLKQNSGT
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2553_LEGPA
Sequence: MMVAHTAQQLDLREKLLTNGVHSLSDIELLAIFISSGNNRKSCLQLAYELTKHLGNLRNILNADLQSFKSIHGLGEVRYAQLQAAKEICHRSDFIDLQKEIRLSNTQQTYAFLKKRLRDYKNETFAALFLDNQHRIIAYEELFSGTINTATVYPRPIVERVLQLNAAALILAHNHPSGLSDASQQDLAITERIRDALDLVDARLLDHIVIGDNEVYSIFAENKWVCN
What are the official names of this protein?
UPF0758 protein lpp2553.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ADDB_LACAC
Sequence: MIKILTGRQTDPVQEKILEEAVKNYQQHPENETFIIVPNHIKFTTEVRAINKLATSKNKSETAVKNLHVLSFSRLAWFFLKDAEQGLPTQLDDAASAMLLTHIIEKEKDNLTIFETINSGLVQQLYNTILQMYDGNIDLDNIDETNLDQETKSKIHDLRIIYDAYIKEIAGKFSTKNEVQVELNKVLANNKSLSNASFYFCDFSHFSLQETLTIKLLIRKAQNVILGFKTKLGDINPQAEAGDYDYVIQQTIKRFTSFLQERNINYTVNNFPLSSKPTNRENLNSLWTESINKVDNIKKHVQLVKADSRYAEAYFVARSIYQQVALGNYRYHDFLILAPDLKEYETYLTPILRQNKIPFFNDLQQEMKYHPLVVLIESLFNMYDEKTISLNTQSIIAILKTHLMIPSWYKEEAEFIHDVDELENFVLAHGIEHNLWQRPFSHFVNAEVIRLDKMDEEIAKLNRLREFLINKITELLEKLKKEESSQKALTMFFDFLTNNGIASRLEQWRNDANDAGDLQQAQQPEQLWDLLIQLLKDYLMINPEKFDVDEFFNMLINAFREANFSQIPSTLDAVNLSELGMVQTGGYKQVFIIGATSGNLPAIQKTPGFLTPENINQLQNSFASDAYLEDNQQLNNLDQNYQFGLALALAQDKVYVSYPILNASNERLDSSIYYKRLFDYVDSEFEQHDLPEKFNDLLSFITSADASLGYLSYINSIDSSKEFDELLRITHEQSPQKTEIVLQASEFNNQPEDIGQELAEKLYGQNLNSSVSQLETFYENSYEYFLTYGLRLHRRLENEFDVIQAGNYFHETFDRLVKQLNKEHIDLASLNSFELERMLNSVRNVMKNEGKYAQLMNDPFNEYLFKCLDHTTSKVAHNWCKNLNKTPLRAKYSELSFGVGEKLKGLSLDVPNLSGNHRVDLRGKMDRVDIAHLADKNQVLAQVIDYKSSAKKFDLSMFYNGIAMQMVSYLDILVKNNQFFAGNNELSLLGAFYQTVTRQLERLNSNKLIDSQLNIRDNVIDGKPKLMYTGLINNNPQVLTEAEPFLDNSSRQSELYSMVKTKKNGTFSLPTDRSFSEEELELLLEYDEFLIKEASNQILSGKIELNPYRQGKSKSALTYSDYKDIFFFDAMLRQNQYHEITRLSKKDLLSKIKERLGKED
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: RF3_XANOR
Sequence: MSDVSNEAARRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKGRKAARHATSDWMALEKERGISVTSSVMQFPYEGKIVNLLDTPGHADFGEDTYRVLTAVDSALMVIDVAKGVEERTIKLMEVCRLRDTPIMTFINKLDREGKNPIDLLDEVETVLGIQCAPVTWPIGMGQRLKGVVHLISGEVHLYEQGRNFTRQDSTIFPSLDAPGLAEKIGEQMLTELRDELELVQGASNPFDLDAYRAGQQTPVFFGSGVNNFGVQPLLDFFIEHAPPPQTRETTGRRVAPSETKLSGFVFKIQANMDPQHRDRVAFMRVCSGKFTAGMKTLHVRSGKDVKLANALTFMASDREIAAEAWPGDVIGIHNHGTISIGDTFTEGESLSFTGIPNFAPELFRRARLRDPLKLKQLQKGLAQLSEEGATQFFRPLMSNDLILGAVGVLQFDVVAYRLKDEYGVDAIFEPVSVTTARWVHCDNVKKLDEFREKNAGNLGIDAAGQLVYLAPTRVNLQLAQERAPDVRFSATREHVHAKAID
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAT_ECOLX
Sequence: MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase, CAT.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.
Protein: STM1_YEAST
Sequence: MSNPFDLLGNDVEDADVVVLPPKEIVKSNTSSKKADVPPPSADPSKARKNRPRPSGNEGAIRDKTAGRRNNRSKDVTDSATTKKSNTRRATDRHSRTGKTDTKKKVNQGWGDDKKELSAEKEAQADAAAEIAEDAAEAEDAGKPKTAQLSLQDYLNQQANNQFNKVPEAKKVELDAERIETAEKEAYVPATKVKNVKSKQLKTKEYLEFDATFVESNTRKNFGDRNNNSRNNFNNRRGGRGARKGNNTANATNSANTVQKNRNIDVSNLPSLA
What is the function of this protein?
Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures.  These structures may be present at telomeres or in rRNAs.  Acts with CDC13 to control telomere length homeostasis.  Involved in the control of the apoptosis-like cell death.
What are the official names of this protein?
Suppressor protein STM1, 3BP1, GU4 nucleic-binding protein 2, G4p2 protein, POP2 multicopy suppressor protein 4, Ribosomal subunits association factor, AF, TOM1 suppressor protein 1, Triplex-binding protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Concentrated in the perinuclear region.
Protein: GCSH_GEOKA
Sequence: MNTPKELRYTKEHEWVRVEGENVRIGITDYAQSELGDIVFVELPEVGAEVTANEPFGSVESVKTVSELYAPISGTVVEVNEALNDHPEYVNESPYDKAWMIVVKPNDLSEIDNLLTAEQYEAMINEG
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.