PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_BURTA
Sequence: MSYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDAAVSAVKQADANPQTFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLTIVSAFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVEAVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVPRADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAAILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVVGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANKGAVTG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PETG_CHAVU
Sequence: MVEPLLSGIVLGLIPITLAGLFVTAYLQYRRGDQLNL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RMD1_HUMAN
Sequence: MALAARLWRLLPFRRGAAPGSRLPAGTSGSRGHCGPCRFRGFEVMGNPGTFKRGLLLSALSYLGFETYQVISQAAVVHATAKVEEILEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVYEALEYAKRALEKNESSFASHKWYAICLSDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTFAEMPWYQRRIAKMLFATPPSSTYEKALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLMKAKDYPAHTEEDKQIQTEAAQLLTSFSEKN
What are the official names of this protein?
Regulator of microtubule dynamics protein 1, RMD-1, hRMD-1, Protein FAM82B.
What is the protein family that this protein belongs to?
Belongs to the RMDN family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Protein: RIMK_VIBVY
Sequence: MRIAILSRNENLYSTMRLKQAGEARGHEVDVIDTLHCYMDITSNNPKIRYKGEELPQYDAIIPRIGASVTFYGTAVVRQFEMMGTFVVNESVAISRSRDKLRSLQLLSRKGIGLPRTGFAHHPDNIQDVIRNVGGAPLVIKLLEGTQGIGVVLAETNKAAESVIEAFMGLKANIMVQEFIEEAKGADIRCFVVGNKVIAAMKRQAKEGEFRSNLHRGGSAQLVRLSKEERATAINAAKVMGLNLCGVDILQSKNGPVVMEVNSSPGLEGIEQATNKDVAGMIYEFIEKNAKPNSNRTKGRG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: HIS3_MYCTA
Sequence: MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_RUEST
Sequence: MSRVKGGTVTHARHKKVIKAAKGYYGRRKNTFKVARQAVDKANQYATRDRKNRKRNFRALWIQRINAAVRSHDEALTYSRFINGLNLAGIEVDRKVLADLAVHEPEAFGAIVRQAQDALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RS18_MAGSA
Sequence: MTEVKTERPRPAAAAGGAQRRPFFRRRKTCPFSGEGAPKIDYKDIKLLSRFISERGKIVPSRITAVSAKKQRELAQAIKRARFLGLLPYVVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL5_PARPJ
Sequence: MARLQEFYKEKVVPGLIEKFGYKSVMEVPRITKITLNMGLGEAVADKKIIENAVGDLTKIAGQKPVITKARKAIAGFKIRQGYPIGAMVTLRGQAMYEFLDRFVTVALPRVRDFRGVSGRAFDGRGNYNIGVKEQIIFPEIDYDKIDALRGLNISITTTAKTDDEAKALLASFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NUOB_RALPJ
Sequence: MAIEGVLNEGFVTTTADKLINWTRTGSLWPMTFGLACCAVEMMHAGASRYDLDRFGVVFRPSPRQSDVMIVAGTLCNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALIYGIIQLQAKIRRTNTIARKA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PDXT_CLAM3
Sequence: MAGSTAEQHGDGPLVGVLALQGDVREHVRVLQGFGARTRLVRQPKDLPGISGLVIPGGESTVMDKLSRQFGIAGPLRSAIDDGLPVYGTCAGLIMLADEIVDAIHDQRSIGGLDVSVRRNAFGSQTASFEVDLDVPALGDPPVHAVFIRAPVVASVGPAASALASLDDGRVVAVRQGALLGTSFHPEVTGDLRFHRLFLDMVEDAGRTL
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: PEPE_ECOL5
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLASLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_BURP0
Sequence: MARVCQVTGKAPMSGNNVSHANNKTKRRFLPNLQNRRFWVESENRWVRLRVSNAGLRLIDKNGIDSVLADLRARGEA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CPT1_SOLLC
Sequence: MSSLVLQCWKLSSPSLILQQNTSISMGAFKGIHKLQIPNSPLTVSARGLNKISCSLNLQTEKLCYEDNDNDLDEELMPKHIALIMDGNRRWAKDKGLEVYEGHKHIIPKLKEICDISSKLGIQIITAFAFSTENWKRSKEEVDFLLQMFEEIYDEFSRSGVRVSIIGCKSDLPMTLQKCIALTEETTKGNKGLHLVIALNYGGYYDILQATKSIVNKAMNGLLDVEDINKNLFDQELESKCPNPDLLIRTGGEQRVSNFLLWQLAYTEFYFTNTLFPDFGEEDLKEAIMNFQQRHRRFGGHTY
What is the function of this protein?
Uses dimethylallyl diphosphate and isopentenyl diphosphate to catalyze the cis-prenyl chain elongation and produce the 10 carbon product neryl diphosphate.
What are the official names of this protein?
Dimethylallylcistransferase CPT1, chloroplastic, Cis-prenyltransferase 1, SlCPT1, Neryl-diphosphate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the UPP synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RGP5_ARATH
Sequence: MSLAEINKNEVDIVIGALNADLTQFLTSWRPFFSGFHLIVVKDPELKEELNIPEGFDVDVYSKTDMEKVVGASNSTMFSGYSCRYFGYLVSKKKYIVSIDDDCVPAKDPKGFLVDAVTQHVINLENPATPLFFNTLYDPYCEGADFVRGYPFSLRSGVPCAASCGLWLNLADLDAPTQALKTEKRNTAYVDAVMTVPAKAMLPISGINIAFNRELVGPALVPALRLAGEGKVRWETLEDVWCGMCLKHISDHLGYGVKTGLPYVWRNERGDAVESLRKKWEGMKLMEKSVPFFDSLKLPETALKVEDCVIELAKAVKEQLGSDDPAFTQAADAMVKWVQLWNSVNSSA
What is the function of this protein?
Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides.
What are the official names of this protein?
Probable UDP-arabinopyranose mutase 5, Reversibly glycosylated polypeptide 5, AtRGP5, UDP-L-arabinose mutase 5.
What is the protein family that this protein belongs to?
Belongs to the RGP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus. Note=Localized predominantly in the cytosol.
Protein: VNB_INBLN
Sequence: MNNATFNYTNVNPISHIRGSVIITICVSFTVILTVFGYIAKIFTKNNCTNNDIGLRERIKCSGCEPFCNKRDDISSPRTGVDIPSFILPGLNLSESTPN
What is the function of this protein?
Putative viral proton channel.  May play a role in virus entry (By similarity).
What are the official names of this protein?
Glycoprotein NB.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses type B glycoprotein NB family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type III membrane protein.
Protein: NGFV2_PSETE
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELASAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRETHPVHNRGEYSVCDSISVWVANKTKAMDIKGKPVTVMVDVNLNNHVYKQYFFETKYRNPNPVPSGCRGIDSGHWNSYCTTTQTYVRALTMEGNQASWRFIRIDAACVCVISRKTENF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 2, v-NGF-2, vNGF-2.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYL_ALCBS
Sequence: MDVQYRPDQIEAQAQQYWDDNQSFKVTEDASKEKFYCLSMFPYPSGRLHMGHVRNYSIGDVVSRYQRMLGKNVLQPMGWDAFGLPAENAAIKNKVAPAKWTFENIDYMRGQLQRLGFGYDWGRELATCTPEYYRWEQWFFTKLYEKGLVYRKMSTVNWDPVDQTVLANEQVIDGRGWRSGALVEQKEIPQWFIKITDYADELLNDLDQLDGWPEQVKTMQRNWIGRSEGVELDFPIEGEESLRVYTTRPDTLMGVSYVAVAAGHPLAQKAAAANHEVADFIKECQNTKTAEADMATMEKKGIYTGLTATHPISGEAVPVWIANFVLMGYGTGAVMAVPAHDQRDFEFAQKYGLPINQVIEPANGEPIDLALEAFTGKGTLIHSGEFDGLSSAEAFNAIANWLSERSLGEKKVNYRLRDWGVSRQRYWGTPIPMVETEDGTLHPTPEDQLPVALPTDVEMDGVTSPIKADPEWAKTTFNGQPALRETDTFDTFMESSWYYARYCSPQSDTAMLDPAATNYWLPVDQYIGGIEHAILHLLYSRFFHKLLRDTGLVNCDEPFKQLLCQGMVLKDGAKMSKSKGNTVDPQQMIEEYGADTVRLFMMFAAPPEQSLEWNDAGVEGAFRFIKRLWRLVAEHVEAGNTGTLDVNALDDAGKALRRKTHETIQKVSDDYGRRNTFNTAIAAVMELINEVSKFDAATDNALAVKQEALEAAVLLLAPIIPHAGHSLWQALGHDEAVIDASWPSVDESALVKDSIELVVQVNGKVRAKLNVPANADKASVESLAMDEPNVKKFTEGKTVRKVIVVPGKLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH2_GEOSE
Sequence: MKAAVVNEFKKALEIKEVERPKLEEGEVLVKIEACGVCHTDLHAAHGDWPIKPKLPLIPGHEGVGIVVEVAKGVKSIKVGDRVGIPWLYSACGECEYCLTGQETLCPHQLNGGYSVDGGYAEYCKAPADYVAKIPDNLDPVEVAPILCAGVTTYKALKVSGARPGEWVAIYGIGGLGHIALQYAKAMGLNVVAVDISDEKSKLAKDLGADIAINGLKEDPVKAIHDQVGGVHAAISVAVNKKAFEQAYQSVKRGGTLVVVGLPNADLPIPIFDTVLNGVSVKGSIVGTRKDMQEALDFAARGKVRPIVETAELEEINEVFERMEKGKINGRIVLKLKED
What is the function of this protein?
Active with primary alcohols, including methanol.
What are the official names of this protein?
Alcohol dehydrogenase, ADH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: DEF_THISH
Sequence: MAKLEILHFPDPRLRKRAVPVDKVDDEIRRLVDDMFETMYDAPGIGLAATQVNVQRQVIVIDVSENNDQPLVFINPEILDRVGEEEMQEGCLSVPGYFETVRRADRVRVRALDRNGEPFELETDGLLAVCIQHEMDHLDGKLFVDYLSPLKRNRIQKKLEKLTRQGALPKNIDRQHAI
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PRSA_STRZT
Sequence: MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GLTP_BACSU
Sequence: MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLDLSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAAGIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLVGTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVVSKWEKAFRQKEWVSANSQTESI
What is the function of this protein?
Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate.
What are the official names of this protein?
Proton/glutamate-aspartate symporter, Proton/glutamate symport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y6202_DICDI
Sequence: MKFKRDENQNSTHHRGNKNNTNNDDDDKEEEEEIINDTTMPPLNNEEKYFLKKIFPFLPSRSSSSTSKLIFSLILDLVGFFTQIIPIFGFAFWPSISTYLIFKVYGSGLHLCVSFLEETIPGLGFIPTATCCWANEKYNIIPKVDRYLPTRYIKMVRNFISAFKKIAIAVALIAIYKIISYFSPYLPFFGGSKNHQTSY
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0284801.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KLH25_MOUSE
Sequence: MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:34491895).  The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813).  The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813).  The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:34491895).  BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895).
What are the official names of this protein?
Kelch-like protein 25.
Protein: UGTP_BACC7
Sequence: MIKNPKVLILTAHYGNGHVQVAKTLEQTFRQKGIKDVIVCDLFGESHPVITDITKYLYLKSYTIGKELYRLFYYGVEKIYDKKIASWYANFGRKRLKLLLQAEKPDIVINTFPIIAVPELKKQTGISIPVYNVLTDFCVHKIWIHREVDRYFVATDHVKKVMVDIGVPAEQIVETGIPIRSSFELKINSDIIYNKYQLCKNKKILLIVAGAHGVLGSVKELCQSFMSVPDLQVVVVCGKNEALKQDLLGLQEKNPDALKVFGYVENIDELFRVTSCMITKPGGITLSEAAALQVPVILYKPVPGQENENAMYFERKGAAVVIRDDSEVFAKTEALLQDDMRLLQMKEAMKSIYRPEPADHIVDTILAENHVEPNHIPIKSPALAQSFT
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Beta-triglucosyldiacylglycerol synthase, TGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: CP301_DROME
Sequence: MNNLSLKAWRSTVSCGPNLRQCVPRISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTIPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYNHKPLDYAVTFMYAPDGPLRFKMTRV
What are the official names of this protein?
Probable cytochrome P450 301a1, mitochondrial, CYPCCCIA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: PTH_STRT1
Sequence: MTKLVVGLGNPGSKYHETRHNVGFMAIDLMAKELGLTFSEEKTFKAEVASTFLNGEKVYFVKPTTFMNLSGLAVRALLAYYNIPMEDFIVIYDDLDMEVGKLRFRQKGSAGGHNGIKSIIAETGTQEFDRIKIGIGRPQKGMTVVNHVLGKFSEDDYAMILLTLDKVETALHHYLKTNDFEDTMRRYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH2_VIBVU
Sequence: MTNYYAEITGWGKCLPPAVLSNDDLSTFLDTSDEWIRTRTGIENRRISHVNTSDLATVAAKQALARAGITAQDIDLIIVATCSPDSLIPNIASMVQKNLEIEAAAAFDLNAACTGFVYGLETGTRLIQSGAYRHALIIGAERLSFYIDWAMRDTAVLFGDGAGAVVLSRTEEAVGLQNAKSGCDAQGRDILSVPKFGTSMDRFAADNGYWDFNFVGKEIFKRAVKGMGSAAAHVLAHAGMSKDDINVVIPHQANIRIIQTLCDLSGIDQSKAFVNIQKYGNTSAATVPIALCEAVEQGHIKAGDNILLAAFGAGLTWGAGLVKWGQRVEAISESDAALPECDKSALELLKNAIELCNARRDK
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III 2, Beta-ketoacyl-ACP synthase III 2, KAS III 2, 3-oxoacyl-[acyl-carrier-protein] synthase 3 2, 3-oxoacyl-[acyl-carrier-protein] synthase III 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_LARHH
Sequence: MQRITVLGATGTIGVNTLDVIARHPERFSVFALTGHRQVDRLAGQCRQFRPQVAVVADAAAAGELARQLSGMNVEILHGEAALVAVAASGSVDAVMSAIVGAAGLAPTMAAVRAGKQVYLANKESLVVAGRLMMEAVAASGSRLLPIDSEHNAIFQSLPADFSGDLDASGVERIVLTASGGPFRGWSAQQLAHVTPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNAPPGRIEVIVHPQSVIHSMVRYRDGSVVAQLGVPDMRTPIAHALAWPERMDAGVPALDFSLLGGLTFEKPDQEHFPCLGLAFDALREGGDQPAVLNAANEVAVAAFLEKRLAFMDIPRLVQKAMHQFAGRVSNSIEELLELDAEVRRHLLCSLAN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.