Protein: PPZA_METRR
Sequence: MTYDEGGHRNNEETPQDVNMSSNNEGMSTSSPTGSYGEIIGQATVSVPQEDQEKLTPLNELSGLYAERESYQSPLCPSTTKMISETVRKSSADDGYTSFPIRSTLIDRPVLDKTLRCEFALFPPFCDIQRLSTLSNASWALIAGHLTNSTKVIVGIPAFGESTSVHNIESGTALQPAPIPLLIDWRPEQSVMDYLKHVQSRIADVTTLGGAGSQLLTSGYPVNYNAGHLQTLIVVETNEISPGSINGTREVQLRQYDYKKKYACAALVIEIRLQKTGIVAVASFDTRALGPSLVYNLLKRLEYVMEQLFRVSSDHVLADIDMVTSEDLEQIWQWNDPIPAPVERCMHEMVQEQCRLQPNTLAVDAWDGRLTYRELDQLSNRLACHLVDRGVEPDMFVPLCFHKSMWMPVTAMGVLKAGGAFVLLEPSFPEQRLRAIVEETEASIVLASSTTMALSLRLLDNVIQVDSELFNCLTFSANRLPQLQPSSSAMFGVFTSGSTGKPKGAVLTHANYCSALTYQLDLLGFKKDSRVFDFASYAFDVSVHNIFASLASGACLCIPSEEKRLEDICKSISDMRATIVHLTPSVARLIQPEKVPLLQTVIFTGEPLSVEDVEQWWGKTNIVNEYGPAECSINTINSNPSSPEEATLIGKGVGVAVWIVDPSNHDLLVPIGSVGELLIEGALVGRGYINETEKNAAAFIENPKWLLHGRPGRPGRQGRLYKTGDLVKYGENGNLAFVGRKDTQVKIYGQRVDLREVEHWIQSCGQGAGQVVAEMIAPRADDHDPAPALVAFLRNEHTALDGSLCPNSTEAILRPVPDEVEARLSKHLPNYMVPKVFIVLSKFPMTATGKTDRMQLRKIGSSFSLEQLAEVRAKTWAGPKRQPLSDMERLLCDVWSKVLGLERRSIGPESNFFHLGGDSIAAMKSVGEARKSGIKVAVADVFRHPSLQDLSRQSKYIEDNSLDHIKPFELLGEEFNRLAFLKDASHQYGIDPSAIYDAYPCTPLQEGLMSLTAKRPGDYIEQMILELGEDVKIDNLWAAWKHVACVTPILRTRLVHHNDLGLMQLVIEEDTSWTDATGLDEYLDADRKRSMNLGEPLSRYGLVRDETGEPKWFVWSIHHAIYDGWSVQLILDAAYRAYSGQEVEQGPQFQEFIKYVQQQRHQNQKRVVEYWQKTLEGFEGAQFPPVVPSVQQPVANTAVRHCIPNPPNGRVGVTMSMLIRAAWALVVGRMANSDDVVYGSTLYGRNASVAGLDELAAPTIATVPLRIRLSSKKTVSEYLEAIQREATTMIPFEQTGLQEIAQMSDSCRMACKFQTLLVIQPEEHSQGKGPLGTWQVRSQEQWFSTYPLTLELWLGTDHITASAMFDSRIIESWVVRKMLQRLEGVMYQLNHATSSQLLGDITILTTEDLEQIWEWNKTIPTPVNRCVHEIIHDKVQHRPNAPAICAWDGEITYSELNRLADKLSGRLTELGVGPHLLVPLCFEKSLWTAVAILGVIKSGGGFVLLDASLPEQRLRSIMKQIKGDLVITCPSQQALCSRLGAETITLSWGFFSTLKDYEAGLQIQSYSPSSILYAVFTSGSTGIPKGVLITHANMASALYYQSEVMGLSEDSRLYDFASYSFDVAISNMFTVLAAGGCLCVPSEEHRKNNLEGSIISLRANALDLTPSIAQLLSPARLPNVRSLTLGGEPVLATAVEQWFGKLQIRNAYGPSECTPTCIVNHNPSSPEQATEIGNGVGIVTWVVDPSNHEVLLPPGCTGELLLEGPLVGPGYLDDGEKTAAAFVHDPVWLTKGTHNRSGRHGLLYKTGDLAKYHENGTLSFVRRKDTTQIKLRGQRVELGEVEHILRSHSCVIDAVAASQCDDKLGAWIAGFVTIRADGQKEHQGDEEYEQQQIQSWEDQFDGETYTSIEEIPREAIGRDFIGWTSMYDGSDLDKGEMNEWLNDTINTILDGGPAGHVLEIGCGSGMMLFNLANKGLQSYIGIEPSKRAVDATASIVKSIPHLKERVRIVKGTGEDLQQLGTPISPDLVVINSVIQYFPSQKYLVKLIQDILELRSVQTIFFGDVRSHALHKEFLALRALSIVGETASREEIGQVLSNLHRAEPELLLDPEFFTSLPARLPGHIAHVEILPKKMEATNELSSFRYGAVVHVDLKHGQIRDIDAKSWVSYTSQGLDCKSLLALLKDWPHAADTIAISDIPHSKTVFATKLIDELENGASEARHGRHWAEFIRQDAKQCCALSAIDLVKLAKEAGYRAEVSWARQYSQRGGLDAVFHRFITDNDARRVLFRFPIDHTNRPFHLLSSKPLRRRAEMNIQRELEARLRCQLPSHMIPQTITILDRMPISHNGKVDRQILADSVQRQWTGQERKRWPTTDTGKELQRIWSHVLNISPDSIGLDDGFVHFGGNSLHAMKIVHMARQAGINLKVTDMFRHSETTIGRLLLDCCCDDTPGKSTSADPVHWTYLMAAIDEKDKCLAAIQAGAKPRLVDGDIQADPDELFTVLLTGANGFIGTQILRQLLEHGRVDRVICIVRGESTSVARHRTIEAAQKALWWTEFHQEMLEVWPGDLSAPRLGLDDAKWRLLAEGKAVNIIIHNGASVNFVKGYAALEAVNVNSTVEMMSVVTRNPGMRFIYVSSARSQDPMEEEEEDMARVLTENPNGYNQTKFVAEALVRRAASRSSPRQHQFMVVSPGLVVGTPTEGVANADDWLWRMAAACIRVGVYNVDDSDKWIPLCDVGTIAAVIIHAALGHPSSSTTVTQVRGGLTMGEFWETLATAGYPLTGTRVAECTAAIREDILANREKHPLGVLEDMLQDLDDTTNVQWAASWRKNGLCSPARLKAALCKSAEFLSGVSFLPLPNFVRERLVQETSMSAFTRSGF
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of pyrrolopyrazines, secondary metabolites showing insecticidal activity (PubMed:30452111).  The single multifunctional NRPS ppzA is responsible for the biosynthesis of peramine (PubMed:30452111).  The condensation domain of ppzA is proposed to catalyze formation of a peptide bond between 1-pyrroline-5-carboxylate and arginine (By similarity).  The methylation domain of ppzA would catalyze the N-methylation of the alpha-amino group of arginine (By similarity).  The reductase domain is proposed to be responsible for reduction of the thioester and the cyclization to form an iminium ion resulting in release from the peptide synthetase (By similarity).  Deprotonation of this intermediate and oxidation of the pyrroline ring would give rise to peramine (By similarity).  This final oxidation to give the pyrrole functionality may be spontaneous (By similarity).  In Epichloe species that produce only peramine, the peramine synthetase gene is not localized in a gene cluster, in contrast to Metarhizium rileyi that contains additionnal pyrrolopyrazine biosynthesis genes (Probable).  The 2-oxoglutarate-Fe(II) type oxidoreductases ppzC and ppzD could be candidates for conversion of proline into an oxidized derivative to be used by the ppzA A1-domain as substrate (Probable).  The other ppz genes encode proteins predicted to derivatize peramine into more complex pyrrolopyrazine metabolites (Probable).
What are the official names of this protein?
Peramine synthetase ppzA, Nonribosomal peptide synthetase ppzA, NRPS ppzA, Pyrrolopyrazine biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.