PharMolix/UniProtQA huggingface dataset:
Protein: NGF_HUMAN
Sequence: MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020).  Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable).  The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.  In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity).  Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).  Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer.  The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Beta-nerve growth factor, Beta-NGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. Endosome lumen. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.
Protein: RHAS_SALA4
Sequence: MTVLHSVDFFPSGKAPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLWRSPDAFQFLAGLDQLLPQEQDGYYPSHWRVNQSVLQQVRQLVGLMERAGDGVDAPAVANREILFMQLLVLLRRSSLMEGATNNDAKLNQLMAWLEDHFAEEVCWEAVAEQFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHSDHSVTEIAYRCGFGDSNHFSTLFRREFNWSPRDIRQGRDAIIQ
What is the function of this protein?
Activates expression of the rhaBAD and rhaT operons.
What are the official names of this protein?
HTH-type transcriptional activator RhaS, L-rhamnose operon regulatory protein RhaS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_DINSH
Sequence: MSDLIAKTTLDQRIAALVTPVIEDLGYELVRLRVMSGKSPTLQIMAEKPEGGIEVDDCARISTEVSATLDVEDPIEDNYTLEVSSPGIDRPLTRLKDFDTWVGYEAKIETTELIEGRRRFKGALAGTEGDEVLIEIEEGTIGLKFEWLSDAKLVLTDDLIRDVLKGRKDAGQVDEAQFDEIQTIIDGDDEPPANTA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_LEGPH
Sequence: MTPKLIVALDFDNQDNAIQLVEKLDPNHCALKVGSELFTLLGPQFVKALVRREFKVFLDLKFHDIPNTVAKACHSAAELGVWMINVHAIGGLKMLQAARESLKTYGKDRPLLIAVTVLTSFEEGELASVGISNTLPEQATHLAMLAREAGLDGVVSSAHEVKIIKQKCGENFITVTPGIRLPNNLKDDQSRVMTPQQAIREGSDFLVIGRPITQASNPYEVVSALLRDL
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: NADK_ENTFA
Sequence: MKVAIVHNSEEKSKQVTKQLTTLLEQNQIQIDNRQPELVISVGGDGTLLSAFHRFNHLLNEVSFLGVHTGHLGFYTDWRDYELKELVESLCIHREKSTSYPLLDVRIRFRDGKPDKHFLALNESTIKRGNRTMVGDVFIKDELFERFRGDGLSISTPTGSTAYNKSIGGAVLHPSINAFQLTEIASLNNRVFRTLGSPIVIAHTEWLEIKLQESDDYFVTVDQLDIYQENIASVCYRIADERIHFASYRHMHFWHRVKDAFIGED
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSLF2_ORYSJ
Sequence: MAATAASTMSAAAAVTRRINAALRVDATSGDVAAGADGQNGRRSPVAKRVNDGGGGKDDVWVAVDEKDVCGARGGDGAARPPLFRTYKVKGSILHPYRFLILLRLIAIVAFFAWRVRHKNRDGVWLWTMSMVGDVWFGFSWVLNQLPKLSPIKRVPDLAALADRHSGDLPGVDVFVTTVDPVDEPILYTVNTILSILAADYPVDRYACYLSDDGGTLVHYEAMVEVAKFAELWVPFCRKHCVEPRSPENYFAMKTQAYKGGVPGELMSDHRRVRREYEEFKVRIDSLSSTIRQRSDVYNAKHAGENATWMADGTHWPGTWFEPADNHQRGKHAGIVQVLLNHPSCKPRLGLAASAENPVDFSGVDVRLPMLVYISREKRPGYNHQKKAGAMNVMLRVSALLSNAPFVINFDGDHYVNNSQAFRAPMCFMLDGRGRGGENTAFVQFPQRFDDVDPTDRYANHNRVFFDGTMLSLNGLQGPSYLGTGTMFRRVALYGVEPPRWGAAASQIKAMDIANKFGSSTSFVGTMLDGANQERSITPLAVLDESVAGDLAALTACAYEDGTSWGRDVGWVYNIATEDVVTGFRMHRQGWRSVYASVEPAAFRGTAPINLTERLYQILRWSGGSLEMFFSHSNALLAGRRLHPLQRVAYLNMSTYPIVTVFIFFYNLFPVMWLISEQYYIQRPFGEYLLYLVAVIAMIHVIGMFEVKWAGITLLDWCRNEQFYMIGSTGVYPTAVLYMALKLVTGKGIYFRLTSKQTTASSGDKFADLYTVRWVPLLIPTIVIIVVNVAAVGVAVGKAAAWGPLTEPGWLAVLGMVFNVWILVLLYPFALGVMGQWGKRPAVLFVAMAMAVAAVAAMYVAFGAPYQAELSGGAASLGKAAASLTGPSG
What is the function of this protein?
Catalyzes both beta-1,3 and beta-1,4 glycosidic linkage on beta-D-glucan.  Essential for (1,3;1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae).  The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley.  They can account for up to 70% by weight of the wall.
What are the official names of this protein?
Mixed-linked glucan synthase 2, 1,3;1,4-beta-D-glucan synthase 2, Cellulose synthase-like protein F2, OsCslF2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like F subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: G1PDH_THEPD
Sequence: MRAELPKRVVVERGALQFLPEVLRELGCSKTVVVTDSGVWSVVGSVVEGALRGLAYEVVYIEAADNSNVERARSAARRVEACAVAGLGGGRPVDVAKYAAFMEGLPFVSVPTAISHDGFASPIVALKDPEGNPLSIFTRPPAAVLVDLAVVSRAPRRLLASGVGDIVGKVTSVADARLAQRLTGEEVPEVALRMAETAARMVLDEVDEIASWTERGVGVLAQAGLLAGMAMAVAGSSRPCSGSEHLFSHSLDKYVPWKKSLHGEQVGVGAIIASYLHGFNWRVIRDALAKVGAPTTVEGLGVTGEDAVRALLKARELRKRFTILDVVELNEGLAWKVLRETGVAPTA
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_CHLSY
Sequence: MYAIIRDRGMQYRVEPGQVLTIDLISAEPGSQIELGEVLLVGDAEQVKVGSPLVEGAVVRAEVLGEQKGDKIVVFRYRNKTRYRRRTGHRQRYTKIRISEIVA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: UPP_BURCJ
Sequence: MKQDSRFPNLFITDHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPITTKRVETPLVAVDAPVIAGKKLAIVPVLRAGIGMSDGLLDLVPSARVGHIGVYRADDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAVHAVDVLKRRNVPAANIMFVALVAAPEGVQVFQDAHPDVKLFVASLDSHLNEHAYIVPGLGDAGDRLFGTKN
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GPDA_SYNJB
Sequence: MNTSAEGQSPTSPQSVAILGAGAWGSTLAMLAQGQGHRVRVWNRRKGLDLAEVLQGSQILISAVSMAGVRPVVEAVRQVGIPPQAILVSATKGLDPLQLLTPTQIWGATFPEQPLVVLSGPNLSAEIRQGLPAAAVVASRDPWAAVQVQYALSSERFRLYTSSDPLGVELGGTLKNVIAIAVGVCDGLQLGANARAALVTRGLAEMIRVGSKLGARAETFNGLSGLGDLLATCHSRLSRNYRVGYGLGQGQPLSQILAEIEGTAEGVYTAPVVVEIAAQHGIQVPITQEVHLLLQGQTTPTAALTRLMERQLTSE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_AZOSB
Sequence: MKASELRAKSVDELNGELLELLKAQFSLRMQLATQQLSNTSQIGKVRRDIARVRTLLREKAGQK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SECA_ACIAC
Sequence: MASNFLTKLFGSRNDRLLKQYRKTVARINAMEPEYEKLSDDALRAKTVEFQGRVARGESLDDLLPEAFAVGREASKRVMKMRHFDVQLLGGMALHHGKISEMRTGEGKTLTATLPVYLNALGGKGVHVVTVNDYLANRDARWMGRLYNFLGLTVGINLPQMPREEKQAAYAADITYGTNNEYGFDYLRDNMVYEARDRVQRALNFAIVDEVDSILIDEARTPLIISGQAEDHTAMYIAMNKVVPLLVRQEGEADPRTGEGVTKPGDFTIDEKSHQVFLTEQGHETAERVLAAQGLIPEGASLYDPSHITLMHHLYAALRANHLYHRDQHYVVQNGEIVIVDEFTGRLMSGRRWSEGLHQAVEAKEGVEIQAENQTLASITFQNYFRLYSKLSGMTGTADTEAYEFQEIYGLETVVIPPNRPSKRDDQLDRVYKTTREKYEAAIQDIRECHERGQPVLVGTTSIENSEIIDDLLNKAGLPHQVLNAKQHAREADIVAQAGRAGMITIATNMAGRGTDIVLGGNIEKEVAAIEDDESLDEATKQARIAALREQWAADNEKVKALGGLRIIATERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDSLMRIFAGERVRAIMERLKMPDGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVANDQRKVIYQQRNEILDAADLSGVIAGMRESCLTDIVRQYVPEESVEEQWDLAGLEKALADEWQIRLPLQQEVESAQAITDGEILEKVVAAGNAAFQAKVDMVGPENFHQFQRAVLLQSFDSNWRDHLSALDYLRQGIHLRGYAQKQPKQEYKREAFELFRQLIDQVKNEVTRILLTVQVQSPSELDQAAEALESRAEQIANVTYTAPTETGEPETLPDPRTAGAGGDGLNLPEGVRIGRNDPCPCGSGKKYKQCHGKLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: YDZA_SCHPO
Sequence: MELELDLLTGLQLLSEYCPRVTPNAPPRRASVAVIIAFKESQDFSNPKWPQCIPITSVPYVLLIQRSFRDTDRWSGHMALPGGTRSLTDKSDIQTAHRETLEEVGIDLRKEHAHFVGALDERVITSNWGQFPLLLLSSFVFILPYMPSLRLQESEVFSAQWYPLADLLLPECQTRIQIDSSRALKKTYPRFIKTLFHLAVGNLMYSAIRLEFDPSSATYSLPPYQRPFLRGITHSIFVDLFIFLSPSSARHCLCWSLPYFQHYDLRFIASFFTQFYRLRLHQVYPRGNWVFTCLNGYYPYLKLTLLVGFLFRLFLVYLLFLIISAYYKS
What are the official names of this protein?
Uncharacterized protein C14C4.10c.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROK_YERPB
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFFDSDQEIERRTGADVGWVFDVEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQVDEPPREVLEALAKERNPLYEEIADVTIRTDDQSAKVVANQIINMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANO8_MOUSE
Sequence: MAEAASGAGDVTLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGIRRISPITRAEEFYYPPWKRLLFQLLVSLPLCLACLICVFILMLGCFQLQELVLSVKGLPRLVRFLPKVMLALLVSVSAEGYKKLAVWLNDMENYRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKDMDRLKEMLATLLITRQLLQNVREVLQPHLYRRLGSGELGLRTILELARALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEENEEEEEAAVERRPAGEGGEVPEGPRGGKEEDEEEDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAGRRRPGPSPDGLLEEGSPTMVEKGLEPGVFTLAEEDDEPEGPPGSPGPEPQTVLLRRARGEGRDQGPDGDRDTETGSGDAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPEAAIVSVVVLEHLALLVKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQQRFQQQQRRRREEEERQRHAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGHRP
What is the function of this protein?
Does not exhibit calcium-activated chloride channel (CaCC) activity.
What are the official names of this protein?
Anoctamin-8, Transmembrane protein 16H.
What is the protein family that this protein belongs to?
Belongs to the anoctamin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Protein: ACCD_AERHH
Sequence: MSWLEKILPKSKITTPRRHNIPEGVWTKCSACEQVLYRAELERNLEVCPKCDHHMRISARARLESFLDEQGRTEIGAELEPQDVLKFKDSKRYKDRLSAAQKETGEKDALVVMKGTLKGVPVVACSFEFSFIGGSMSSVVGARFVRAVEESIKEGRGLVCFSTSGGARMQEALFSLMQMAKTSAALDRLSKAGLPYISVLTDPTMGGVSASLAMLGDINVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEKGAIDLIIDRREMRNRLASLLAKMLNTHVIEE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_OPITP
Sequence: MSKKKKSMYLHESASGAAPKIQRRYDPAFEVDAAYRASLPDMMEAAYAAIQGAHVPIQQVGVSNFKLPLKFRTKKGEILTLEASITGTVSLEADLKGINMSRIVRSFYDHKDEVFTGEWMGKILCAYLRNVKSKDARLKVSFSYPMLHRSLRSGLEGYQFYNVAFEGVLTRKGDYRRFIHFDFVYSSACPCSAELAEHARDQRGVYSVPHSQRSKARIVVEETQGKKIWIEDVHAHCLRALQTETQVMVKREDEQAFAELNGAHLKFVEDAARLLYREFDADEKIADFRIACSHLESLHSHDAVSVICKGVKGGFTADFMDFQSLVC
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: TRPB_VIBA3
Sequence: MAKLDAYFGEYGGQYVPQILVPALDQLEQAFIDAQADPEFRSEFMTLLQEYAGRPTALTLTRNLTKGTKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKQEIIAETGAGQHGVATALACALLGLKCRVYMGAKDVERQSPNVFRMKLMGAEVIPVHSGSSTLKDACNEALRDWSATYEDAHYLLGTAAGPHPFPTIVRDFQRMIGEETKNQILAREGRLPDAVIACVGGGSNAIGMFADFIEEESVRLIGVEPAGKGIDTDQHGAPLKHGKTGIFFGMKAPLMQDENGQVEESYSVSAGLDFPSVGPQHAHLNAIGRAEYDNVTDDEALEAFQLIARKEGIIAALESSHALAHAVKMAHDDPEKEQLLVVNLSGRGDKDIFSVHDILKEKGAL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: TRUB2_HUMAN
Sequence: MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ
What is the function of this protein?
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916).  As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).  Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933).
What are the official names of this protein?
Pseudouridylate synthase TRUB2, mitochondrial, TruB pseudouridine synthase homolog 2, tRNA pseudouridine 55 synthase TRUB2, Psi55 synthase TRUB2.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules, platforms for post- transcriptional RNA modification and ribosome assembly.
Protein: PP167_ARATH
Sequence: MPISNPRKRPICVAQSFLSKHATKAELSQAVSRLESLTQQGIRLPFDLLASLLQQCGDTKSLKQGKWIHRHLKITGFKRPNTLLSNHLIGMYMKCGKPIDACKVFDQMHLRNLYSWNNMVSGYVKSGMLVRARVVFDSMPERDVVSWNTMVIGYAQDGNLHEALWFYKEFRRSGIKFNEFSFAGLLTACVKSRQLQLNRQAHGQVLVAGFLSNVVLSCSIIDAYAKCGQMESAKRCFDEMTVKDIHIWTTLISGYAKLGDMEAAEKLFCEMPEKNPVSWTALIAGYVRQGSGNRALDLFRKMIALGVKPEQFTFSSCLCASASIASLRHGKEIHGYMIRTNVRPNAIVISSLIDMYSKSGSLEASERVFRICDDKHDCVFWNTMISALAQHGLGHKALRMLDDMIKFRVQPNRTTLVVILNACSHSGLVEEGLRWFESMTVQHGIVPDQEHYACLIDLLGRAGCFKELMRKIEEMPFEPDKHIWNAILGVCRIHGNEELGKKAADELIKLDPESSAPYILLSSIYADHGKWELVEKLRGVMKKRRVNKEKAVSWIEIEKKVEAFTVSDGSHAHARKEEIYFILHNLAAVIEEEASRT
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g21090.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: PLSX_GLOC7
Sequence: MASSRARIAVDAMGGDYAPDEIIAGAIRASAELEVDVLLVGDSHRIESYLQQHHKPINVEIIHAEEVIAMDEEPLSAIRRKSKASINVAMDLVKEKRADAVVSAGHSGAAMASALLRLGRLKGIDRPAIGAVFPTILAGKSVIVLDVGANVDSRPKYLEQFALMGTIYSKYVLGIEEPKVGLLNIGEESSKGNDLALRTYQLLEANESIPFVGNAEGRDVLSGHFDVIVCDGFVGNVLLKFAEAVGEVMLQIIREELPQGLRGQLGTALLKPNLKRLKQRIDHAEHGGGLLFGVAGVCIISHGSSQAPSIFNAIRLAQDAINNQVLERIQAYNEQHQQESQNSTETVTSEQ
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: HEMA_I59A0
Sequence: MERIVLLLAIVSLVKSDQICIGYHANKSTKQVDTIMEKNVTVTHAQDILERTHNGKLCSLNGVKPLILRDCSVAGWLLGNPMCDEFLNVPEWSYIVEKDNPINSLCYPGDFNDYEELKHLLSSTNHFEKIQIIPRSSWSNHDASSGVSSACPYIGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLILWGIHHPNDAAEQTKLYQNPTTYVSVGTSTLNQRSIPEIATRPKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSGLAYGNCDTKCQTPVGAINSSMPFHNIHPHTIGECPKYVKSDRLVLATGLRNVPQRKKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGITNKVNSIIDKMNTQFKAVGKEFNNLERRVENLNKKMEDGFLDVWTYNVELLVLMENERTLDFHDSNVKNLYDKVRLQLKDNARELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLNREEISGVKLESMGVYQILSIYSTVASSLALAIMIAGLSFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: DOGL4_ARATH
Sequence: MSKMRNLVEEKFLEFYESWVIQLELYLHQLLIAHNNNTMSETELRHLISKLTTHHKAYYTAKWAAIREDVLAFFGSVWLNPLENACSWLTGWKPSMVFRMVDRLRKSRVVLVEAQVKKLEELRVKTKFDEQKIEREMERYQVAMADRKMVELARLGCHVGGESVMVVEAAVRGLSMGLEKMVKAADCVRLKTLKGILDILTPPQCVEFLAAAATFQVQLRRWGNRRHYVTHS
What are the official names of this protein?
Protein DOG1-like 4.
Protein: NU4LM_DACTR
Sequence: MTSINLNLTMAFSLALTGVLVYRSHLMSTLLCLEGMMLSLFILMALLISHSHMFSVSMAPLILLVFSACEAGVGLALLVKISTNYGNDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LPXB_ECO8A
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDIFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RNH2_LEGPC
Sequence: MNTELKILMAGVDEVGRGPLAGAVVTAAVILKKPIDGLTDSKKLSPKQRNLLAIRIKEEALAFAYGRAEVEEIDQLNIHHATLLAMRRAVEALPIQPDNVVVDGAFTPQLNIPCKAIVQGDSLVPEISAASILAKVLRDEEMVALDKIYPGYGFAEHKGYATPVHKEALMRLGPCRIHRRSYSPVADLISK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.