PharMolix/UniProtQA huggingface dataset:
Protein: IF2P_METMP
Sequence: MALRCPIVSVLGHVDHGKTSLLDKIRRTRVTQREAGGITQHIGASEIPINTIKKVSKDLLGLFKADLSIPGILVIDTPGHEAFTSLRKRGGALADIAILVVDINEGFKPQTIEAINILKQCKTPFVVAANKVDRIPGWNSSEGPFILNFNEKNQHPNAMTEFEIRLYENVIKHLNELGFDADLFSRVKDTTKTINVVPVSAMTGEGVPDLLVIISGLAQRFLEQKLALNVEGYAKGTVLELKEEKGLGKTIDAIIYDGIAKTGDFLVVGNPDGVLVSKIKALLKPKELDEMRDPKDKFKPSKQISAATGVKISAPDLDSVIAGSPLRIVPKNQVEAAKEEVLEEVEEFTILTDDEGIIIKADTMGSLEALANELRKVNAKIKKAEVGDISKKDVIEASSYASTNPLNGLIISFNTKVLADAKAEIEKSDVKLLEGKIIYKLVEEHEEWTKEMEELMKSDEINRLTKPAMIKILPNCIFRQKEPAVCGVEVLYGTLKIGSPIMSEDGKKLGYVKEMRDNQQENIKEAKVGMQVPVSIDGNIVLGRNAKENDILYVEVPEPEARKLHHEFKDELRGDEKEALSRYMELKQKIENNIFWGM
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: LPXD_PARP8
Sequence: MAFTLEEIVQRFGGEIVGDRAHRVGNLAPLDQAGPDQLAFLANPKYLAQVETTRAGAVLINAADLAKLASPDGRNFIVTPNPYAYFARLAQAFIDMATPKAKRGVHPSATVDSSAQIAATAVIGPNVTVEAGVAIGENVRLDANVFVGRGTTIGAGSHLYPNVAVYHGCRLGERAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIEECVKIDNLVQIGHNCKIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFPAVDHADWNRSAALMRNLDKLRDRIKALEAAVASASGDKA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: ORN_BURMA
Sequence: MTDISAVAGQPALVRNELNLVWLDMEMTGLDPDTDRIIEIAVVVTNSTLDIAVEGPVLAIHQSDETLAKMDDWNKNTHGRSGLIDRVRASSVTEADAAAQIAAFLAEHVPPGKSPMCGNSICQDRRFMARWMPELERFFHYRNLDVSTLKELCRRWQPAIYKGFQKRAMHTALADIHESIDELKYYRERFLIPAAPAGETA
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY1_MELGA
Sequence: MATEGDKLLGGRFVGSVDPIMEILSSSISTEQRLTEVDIQASMAYAKALEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDEDIQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLVERAAIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPLGSGVLAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPSTFSKDLQEDKEAVLDVVDTLTAVLQVATGVISTLQINKENMEKALTPELLSTDLALYLVRKGMPIRQAQTASGKAVHLAETKGITINNLTLEDLKSISPLFASDVSQVFSVVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA
What is the function of this protein?
Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.
What are the official names of this protein?
Delta-1 crystallin, Delta crystallin I.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: RPOZ_VIBVY
Sequence: MARVTVQDAVEKVGNRFDLVLIAARRARQMQTGGKDSLVPEENDKPTVIALREIEEGLITKEVLDARERQEQQEQEAAELAAVSSIARNR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: QUEF_HELPY
Sequence: MTPELNLKSLGAKTPYIFEYNSQLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSLKLYLFSYRNHGSFHESCINTILLDLVRLLEPKYLEVYGDFASRGGIAIKPFVNYAIKEYQDFKEKRLLNAK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_MYCPN
Sequence: MESIRIGVLGLTNAGKSTLVNQLHKANNLLVSPMNNTTLLAVSTNTITHEKQNITFIDVPGFSEKRHSSYELISQEIRKALSGIDVLLLVVRSDQQQKLPLLQTQLQPLKRYRDLTRVLLINNFFDVVLQAEDKQAIVLDFKPQAVLETDLLHFDATSFWNQFNEVKLQANEFRKDVEFLDADTDNFKILEALREQIIKYCSEEIPHVVRLEIVDKSFDQAKNLLKLHLSISVPKLSQKKIIIGRNAQMVKKIGMQMRQKLLEYYDCNVFVELFVRTYDPKQKKSPYGSLI
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RNZ_YEAST
Sequence: MFTFIPITHPTSDTKHPLLLVQSAHGEKYFFGKIGEGSQRSLTENKIRISKLKDIFLTGELNWSDIGGLPGMILTIADQGKSNLVLHYGNDILNYIVSTWRYFVFRFGIDLNDHIMKDKEVYKDKIIAVKSFNVLKNGGEDRLGVFDSFQKGVLRSIVAKMFPKHAPTDRYDPSSDPHLNVELPDLDAKVEVSTNYEISFSPVRGKFKVEEAIKLGVPKGPLFAKLTKGQTITLDNGIVVTPEQVLENERHFAKVLILDIPDDLYLNAFVEKFKDYDCAELGMVYYFLGDEVTINDNLFAFIDIFEKNNYGKVNHMISHNKISPNTISFFGSALTTLKLKALQVNNYNLPKTDRVFSKDFYDRFDTPLSRGTSMCKSQEEPLNTIIEKDNIHIFSQNKTVTFEPFRMNEEPMKCNINGEVADFSWQEIFEEHVKPLEFPLADVDTVINNQLHVDNFNNSAEKKKHVEIITLGTGSALPSKYRNVVSTLVKVPFTDADGNTINRNIMLDAGENTLGTIHRMFSQLAVKSIFQDLKMIYLSHLHADHHLGIISVLNEWYKYNKDDETSYIYVVTPWQYHKFVNEWLVLENKEILKRIKYISCEHFINDSFVRMQTQSVPLAEFNEILKENSNQESNRKLELDRDSSYRDVDLIRQMYEDLSIEYFQTCRAIHCDWAYSNSITFRMDENNEHNTFKVSYSGDTRPNIEKFSLEIGYNSDLLIHEATLENQLLEDAVKKKHCTINEAIGVSNKMNARKLILTHFSQRYPKLPQLDNNIDVMAREFCFAFDSMIVDYEKIGEQQRIFPLLNKAFVEEKEEEEDVDDVESVQDLEVKLKKHKKN
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MURB_STRAW
Sequence: MPKRPTPSRTLVHVQELHDAPLAPLTTFRLGGPATRLITATTDAEVIAAVREADDSGTPLLLIGGGSNLVIGDKGFAGTALRIATTGFGLDGTKVELAAGEVWTDAVARTVEAGLAGIECLAGIPGSAGATPIQNVGAYGQEVSSTITEVIAYDRKTHETVTIPNAECAFSYRHSRFKADPERYVVLRVRFELEDADGLSAPVKYAETARALGVEPGDRVPLAAARETVLGLRSGKGMVLDPEDHDTWSAGSFFTNPILTEAECAAFHARVRERLGADAVPPAYPAGDGRTKTSAAWLIDKSGFTKGYGSGPARISTKHTLALTNRGEATTEDLLALAREVVAGVRDAFGITLVNEPVTVGVEL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_STAA8
Sequence: MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPVILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERCC3_BOVIN
Sequence: MGKRDRADREKKKSKKRHYEDEEDEEDDAPGNDTQEAVPSAAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITDYLRKLSKTGVPEGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAIAKSVEGSGGPSTSRVTDPQGKSDIPTDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSIAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNSGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSKSSQVSRRFGTMSSMSGADDTVYMEYHSSRSKTSTKHVHPLFKRFRK
What is the function of this protein?
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPB, TFIIH subunit XPB, DNA excision repair protein ERCC-3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AZOR2_PSEPF
Sequence: MSRVLIIESSARQQDSVSRQLTQTFISQWKAAHPADQITVRDLAVNPVPHLDINLLGGWMKSAEQRNDSEQASLDRSNELTDELLAADVLVMAAPMYNFAIPSTLKAWLDHVLRAGVTFKYTETGPQGLLSGKRAYVLTARGGIYAGGPADHQEPYLRQVMGFIGINDVTFIHAEGMNLGGDFQEKGLNQANAKLSQVA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 2, Azo-dye reductase 2, FMN-dependent NADH-azo compound oxidoreductase 2, FMN-dependent NADH-azoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: KCNS1_MACMU
Sequence: MLMLLVRGTHYESLRSKVVLPTPLGGRGTEALVSECPSPDTGIRWRQSDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDGVSEASLETSRETSQEGRSADLETQAPSEPPHPQMY
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
What are the official names of this protein?
Potassium voltage-gated channel subfamily S member 1, Delayed-rectifier K(+) channel alpha subunit 1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.
Protein: RL2_GLOVI
Sequence: MGIRKYRPMTPGTRQRSGADFAEVTKSKPEKKLTKYVHRKQGRNNQGVITSRFRGGGHKRLYRFIDFKRDKRGIPAEVLAIEYDPNRNARIALVQYTDGEKRYILHPVGLKVGARISAGEDAPIELGCALPLEKLPLGSNVHNIELLPGRGGQMARAAGAVAQLMAKEGDYATLRLPSGEVRVVRKECYATLGQVGNLDAKNISIGKAGRQRWLGKRPHNRGVVMNAVDHPHGGGEGKSPIGGKPQTPWGKSALGTKTRKRRKPSSKFIIRRRKTASGRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ASSY_METBU
Sequence: MSKKVALAYSGGLDTSICIPLLKEEYGYDEVITVAVDVGQPKEDVAQAEEKAKKISDKHFTLDVREEFVNDYIFPLIRANGDYEGYVMGTSIARPLIAKKVVEIAEQEGAVALAHGCTGKGNDQLRFEAVFRLTDMDVIAPMREMNLTREWEIEYAKEHGIPVGVTTAKPWSVDENIWSRSIEGGKLEDPGYIPPEEIYKWTTAPEDAPDAQIIEIGFENGVPVSLDGQKMGGVELIEKMNIIAGTHGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHKDLEKLVLTRAELKFKATVDAQWSELAYYGLVDEPLYDDLNAFIDKTQERVAGTVTMKLYKGSVLVLARTSPYALYSEELVSFDGTSIDQKDAEGFAKYHGFQARLYRKFVVKN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSB_APIME
Sequence: MLLHNKTLAGKALAFIAEEGYVPSMREKFLGWNVPPEYSDLVHPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFSTSKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERMIGWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYRTISCPIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTTEGFLTTCSFDFLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHEKMLREQAKKMNVKSLVSNQDKERSAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNRELLTPVSTMLPAVFAKTVSCIDPWIYAINHPRYRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to 11-cis-retinal.
What are the official names of this protein?
Opsin, blue-sensitive, Blue-sensitive opsin, AmBLop.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL11_ALIB4
Sequence: MAKKIQGFLKLQIPAGAANPSPPVGPALGQRGVNIMEFCKAFNEKTKDKAGYRIPVVLTIYTDKSFTFELKQPPMTELIKKISGVKKGSDNPLKNKVGKLSKAQIMEIVDMKIKDLNTDDREVAAKIVAGSARSIGIETEL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PMMS_STRHY
Sequence: MTVQNPQEPEYFPEVFPQDAFPQYAWDEGMRPITLPHEVWLSETTHRDGQQGGLPLSLDTSRRIYDILCEITGDSTAIRHAEFFPYRDSDRNALIYALERHRDGAPIEPTTWIRARREDVELIKRIGVIETGLLSSSSDYHTFHKFGSGGRTQAASMYLDAVTMALDHGIRPRVHLEDTTRSSPDFVRALVEEVLKTAERYPAELQPRFRVCDTLGIGLPYDDVSLPRSIPRWIRLLRGFGLSPSQIELHPHNDTWLVVANCLAAIREGCGVISGTTLGTGERTGNAPLEAVMVHLLGMGYWSGARVNLPAVNKLVELYEGIGAGPSQKYPFFGRDAYVTRAGIHADGLNKFWWMYAPFNAPLLTGRELDVALTKDSGQAGLLFVLNKRLGLQLEKGDPRVAEVLAWMDRQWDAGRVSAVEWSELEPVVEKAFATEEGVG
What is the function of this protein?
Involved in the biosynthesis of the herbicide bialaphos (BA).  Catalyzes the condensation berween phosphinopyruvic acid (PPA), an analog of oxalacetic acid, and acetyl-CoA to form R-2-phosphinomethylmalic acid (PMM) (PubMed:3781934, PubMed:3170341).  Can also act on oxaloacetate, but shows no activity when acetyl-CoA is substituted by propionyl-CoA or butyryl-CoA (PubMed:3170341).
What are the official names of this protein?
2-phosphinomethylmalate synthase, PMS, PMM synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: TIG_STREM
Sequence: MSTSFENKATNRGVITFTISQDKIKPALDQAFNKIKKDLNAPGFRKGHMPRPVFNQRFGEEVLYEEALNIVLPAAYEGAVAELELDVVAQPKIDVVSMEKGQEWTLTAEVVTKPEVKLGDYKDLTVEVEASKEVTDEEVDAKVERERNNLAELVVKEEAAVEGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEEQLVGAKAGDTVEVNVTFPENYQAEDLAGKAAKFVTTVHEVKAKEVPELDDELAKDIDEEVETLDELKAKYRKELEASKEAAYDDALEGAAIELAVENAEIVELPEEMVHDEVHRSVNEFMASMQRQGISPDMYFQLTGTSQEDLHKQHEAEADKRVKTNLVIEAIAKAEGFEASDDEIEKEINDLAAEYSMPVEQVRSLLSADMLKHDIVMKKAVEVITSSAKAK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ARL8B_PONAB
Sequence: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAAYREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation.  Along with its effectors, orchestrates lysosomal transport and fusion.  Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes.  Required for lysosomal and cytolytic granule exocytosis.  Critical factor involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity).  In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity).  Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense.  Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes.  Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing.  Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity).  Involved in the process of MHC II presentation.  Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity).  May play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 8B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Cytolytic granule membrane. Note=GTP- bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (By similarity).
Protein: MNME_MARN8
Sequence: MQPATDTIAAIATAPGQAGVGIVRVSGPRAMAIARTMLGFEPKPRYAHYGPFRDRQGELIDEGIGLYFPNPHSFTGEDVFELQGHGGTVILDILLREVCSLGARLARPGEFSERAFLNDKLDLAQAEAIADLIESSSEQAARCAVRSMQGVFSKRVDNLVEAITHLRIYVEAAIDFPEEEIDFLADGKVASDLQGLLEQVQQILGEAQQGTILRDGMKVVIAGRPNAGKSSLLNALAGREAAIVTAIEGTTRDVLREHIHIDGMPLHIIDTAGLRDSPDEVEQIGIARAWEEIRQADRILLMVDATTTDKTEPHEIWPDFIDQLPRSAPVTVIRNKVDLSGEPLGISAESHQTAPVIRLAAKAAEGLEVLREHLKECIGFASTTEGGFLARRRHLDALERARDSLLQGQTQLEGYGAGELLAEDLRAAQDALGEITGHLTPDELLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CM17_CONBU
Sequence: GLYCCQPKPNGQMMCNRWCEINSRCCGRR
What are the official names of this protein?
Conotoxin Bu17.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SEPF_LACP3
Sequence: MAFEKLGEKFSNFFAMDNEDDYQDQEDEQAQQPAPEQPVDNHYRSNKVVSMATPAGKTAKIVVYEPRVYSDAKEIGSHLLNNRAVVINFDRIGSDDATRIVDFLTGTVFAINGEIKRVGESIFLVTPANFEIDGSLASTIDSDGLNLSSQH
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RECR_SHEPW
Sequence: MKFSPLVDELIQSLKCLPGVGPKSAQRMAFQLLERDRKAGSKLADSLGKAMSEVGHCQSCRTFTEETYCPICVSTKRGHSSVICVVETPADVLAIEAGGHFSGRYFVLLGHLSPLDGVGPDELGLALLETHLASGEVTELILATNPTVEGDATAHYIADMAKNHELAVSRIAHGVPVGGELEYVDSTTLALSFNGRLPI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: 13S2_FAGES
Sequence: MSTKLILSFSLCLMVLSCSAQLWPWQKGQGSRPHHGRQQHQFQHQCDIQRLTASEPSRRVRSEAGVTEIWDHDTPEFRCTGFVAVRVVIQPGGLLLPSYSNAPYITFVEQGRGVQGVVIPGCPETFQSDSEFEYPQSQRGRHSRQSESEEESSRGDQHQKIFRIREGDVIPSPAGVVQWTHNDGNDDLISVTLLDANSYHKQLDENVRSFFLAGQSQRETREEGSDRQSRESDDDEALLGANILSGFQDEILHELFRDVDRETISKLRGENDQRGFIVQAQDLKLRVPQDFEEEYERERGDRRRGQGGSGRSNGVEQGFCNLKFRRNFNTPTNTYVFNPRAGRINTVNSNSLPILEFLQLSAQHVVLYKNAIIGPRWNLNAHSALYVTRGEGRVQVVGDEGKSVFDDKVQRGQILVVPQGFAVVLKAGREGLEWVELKNSGNAITSPIGGRTSVLRAIPVEVLANSYDISTKEAYKLKNGRQEVEVFRPFQSRDEKERERFSIV
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
13S globulin seed storage protein 2, Legumin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.