PharMolix/UniProtQA huggingface dataset:
Protein: PRM2_ERYPA
Sequence: MVRYRTRSLSERPHEVHGQQVHGQDQGHNGQEEQGLSPEHVEVYERTHQGHSHHRRRRCSQRRLHRIHRRRHRSCRRRRRRSCRHRRRHRRGCRTRRRRCRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-2, Sperm histone P2, Sperm protamine P2.
What is the protein family that this protein belongs to?
Belongs to the protamine P2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: THIG_NEIMB
Sequence: MLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQPAMITVSLRRAGSGGEAHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETDWIKLELIGDDDTLQPDVFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALNVLRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVEARDKAQASTPTVGQPFWHSAEY
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICP4_EHV1B
Sequence: MASQRSDFAPDLYDFIESNDFGEDPLIRAASAAEEGFTQPAAPDLLYGSQNMFGVDDAPLSTPAVVIPPPSPTPEPRGGKAKRSPSAAGSGGPPTPAAAAQPASPAPSPAPGLAAMLKMVHSSVAPGNGRRATGSSSPGGGDAADPVALDSDTETCPGSPQPEFPSSASPGGGSPAPRVRSISISSSSSSSSSMDEDDQADGAGASSSSSSSSDDSDSDEGGEEETPRPRHSQNAAKTPSAAGSPGPSSGGDRPAAGAATPKSCRSGAASPGAPAPAPASAPAPSRPGGGLLPPGARILEYLEGVREANLAKTLERPEPPAGMASPPGRSPHRLPKDQRPKSALAGASKRKRANPRPIPQTQTQAPAEEAPQTAVWDLLDMNSSQATGAAAAAASAPAAASCAPGVYQREPLLTPSGDPWPGSDPPPMGRVRYGGTGDSRDGLWDDPEIVLAASRYAEAQAPVPVFVPEMGDSTKQYNALVRMVFESREAMSWLQNSKLSGQDQNLAQFCQKFIHAPRGHGSFITGSVANPLPHIGDAMAAGNALWALPHAAASVAMSRRYDRTQKSFILQSLRRAYADMAYPRDEAGRPDSLAAVAGYPAQAAAAAASQQQPEAPAPSVRVREAYTRVCAALGPRRKAAAAAAAPGTRAPRPSAFRLRELGDACVLACQAVFEALLRLRGGASAVPGLDPSEIPSPACPPEALCSNPAGLETAALSLYELRDLVERARLLGDSDPTHRLGSDELRLAVRAVLVVARTVAPLVRYNAEGARARASAWTVTQAVFSIPSLVGGMLGEAVSLLAPPTRSQQPSSSSPGGEPFSGSAAAEGSLQTLPPLWPTVPGKQSATVPSSHSQSPQHSQSGGGAGATTATCCRATQTNARSRGQQHQPQKARSPQAAASPAHLSQEAMPGSSSDDRAIHGRPRGKSGKRRSEPLEPAAQAGASASFSSSARGYDPSGPVDSPPAPKRRVATPGHQAPRALGPMPAEGPDRRGGFRRVPRGDCHTPRPSDAACAAYCPPELVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPARDGARFGELAASGPLRRRAAWMHQIPDPEDVKVVVLYSPLQDEDLLGGLPASRPGGSRREPLWSDLKGGLSALLAALGNRILTKRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVSTEDWPQDGPAISQYHIYMRAALTPRVACAVRWPRERHLSRAVLTSSTLFGPGLFARAEAAFARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDMRAQAEGLGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRGAGAVEPSELLIPELLSEFCRVALLEPDAEAEPLVLPITEAPRRRAPRVDWEPGFGSRSTSVLHMGATELCLPEPDDELEIDGAGDVELVVEHPGPSPGVAQALRRAPIKIEVVSDDEDGGDWCNPYLS
What is the function of this protein?
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis.
What are the official names of this protein?
Major viral transcription factor, 155 kDa immediate-early protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae ICP4 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RNC_BORPA
Sequence: MTAMSLATLETRLDHRFGDKALLEQALTHRSHGARHNERLEFLGDSVLNFVVAAMLFERYGKLDEGDLSRLRANLVKQASLADIAQRLDLSQYLRLGEGELKSGGFRRPSILADTVEALFGAVFLDAGFEAARRVIVRQYQPVMAHVDPKTLGKDAKTLLQEFLQGRKLALPQYTVVATHGAAHSQQFEVECAIPALEIKIVAPGASRRAAEQSAAKVALEAAQAVLPAARAARKSGKARKTAQLSLPVAVAQEVK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_BIFLD
Sequence: MKISVRNLEPTKVKLTVTVEPEELNPYLDAARKEIAKQVNVPGFRKGHVPGKIIDQRIGFAAVAGEAVNDAVPELYSKALDEKKIRPMAQPEFDVQDVPQSANDETKLKFTATVERRPDIELPEIDGLEIAISKPEVKDEDVDKRLETLRQRFGTLVGVDRPAAKGDFANIDLTAEIDGETVDSQEGVSYELGSNTMLDGLDEALDGLSAGEETTFEGTLEAGEHEGQKATVKVKVNSVKAEELPELNDEFASEASEFDTLDELKADIRKAAAQDAEGRQATEARDAFIAKLQEGLEIPVPKGVKANMVEEQLKGMTPDPEKATKEQKAQAEETVEKDLRDQMVLDALAEKLDVQVSQSDVFNFLASIAQQYGMDPNNFIQAIIKNGQLGSAVQEVGRSKGLLAGMRAVKFTADGEVVDLSAFLGEAAEDEESESVEAASAAAAVADELSAKDDAKDAE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RM25_SCHPO
Sequence: MPVFTKEALERLPIQLGNFFKKFPPENPNAWTTNPNRQNPFLATRNPQNGLVINPYYSNRRQAEIYKEARLQNLDNLLPQQMSWQKDSTRHILKGLLNPKGKISERKRDEILENRRLKLSESLKKTSKFKNERQKASKIAKPSPF
What are the official names of this protein?
54S ribosomal protein L25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL59 family.
Protein: LACC_LEPMG
Sequence: VTIGKEGTLT
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (By similarity).  In vitro, has activity towards 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), catechol and hydroquinone but not towards 2,6-dimethoxy-phenol or guaiacol.
What are the official names of this protein?
Laccase, Benzenediol:oxygen oxidoreductase, Diphenol oxidase, Urishiol oxidase.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SNAK2_SOLTU
Sequence: MAISKALFASLLLSLLLLEQVQSIQTDQVTSNAISEAAYSYKKIDCGGACAARCRLSSRPRLCNRACGTCCARCNCVPPGTSGNTETCPCYASLTTHGNKRKCP
What is the function of this protein?
Has an antimicrobial activity.  Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria.
What are the official names of this protein?
Snakin-2.
What is the protein family that this protein belongs to?
Belongs to the GASA family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: SNU71_LODEL
Sequence: MYRTSTLASKTTSTSGIAFVSPYSIPASNHTKLLSLLSHLESPSNERSESLHLNVNVPVPVQFDASEIIDLNNTKILTQSAELQSHGKNKLPSNQLKDTVNVNDEPELYLDIKTIQPTNLQEQLCIVVLNNFPNLKNIAVEKVLLHLIELGLEDRIEGQQDGKEIKDKARKFAWSLVNYEFIDLKTIFIRFNHVKDVKWFVKTFHDIDAILPKVELIYSAQIDEYLKDLEVLPSVSVTDRLKNQIKLILYNSKNLAKPKIKGFEDLDRAMQSYSDYMVDNNDLIDVPNNMKDSIIREIIRFRTKMLSIEKENRQKQIEIEREKTKQKLNKLFEGIKEASDAQQEQQREQEQEQEQEQEQGQKQKEKFATARTNNQAAETFVMPEEHEELDDKEYDAYVKAQRIAKQNKDYNQRLNAFKAKEEAERTRLELEIKRLQDYEVNVWDNKAATIAKFRNYESNGLANLYEMNYNEYLKQRVAKRTLEEELDRADIEKETQELENEVQPIKHTLDTYESKHAEPEAKRAKFNADQNEADIEVPMSPLEKDKRVIIVKELSLAKQNQIKTKIDDLVEDCLGVKDELLLDVIFQSLESSNFDGRDALVTELEEFLDEDAVKLVDLLYDFVRSLA
What is the function of this protein?
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA.  Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity).
What are the official names of this protein?
U1 small nuclear ribonucleoprotein component SNU71.
What is the protein family that this protein belongs to?
Belongs to the SNU71 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CLPX_BURCH
Sequence: MADKKGSNSEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDEAAAAGVEASLSRSDLPSPQEIRDILDQYVIGQERAKKILAVAVYNHYKRLKHLDKKDDVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQNCNYEVDKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLVEGTMASVPPQGGRKHPNQDFIQVDTTNILFICGGAFDGLEKVITDRTEKTGIGFGATVKSKQERDAGEVLRETEPEDLIKFGLIPELIGRLPVVATLGKLDEAALMKILVEPKNALVKQYHKLFAMERVELEIRPGALQAVARKAIRRKTGARGLRSIIEQALLDVMYELPTMKGVSKVIIDENVIDGDGKPLLIYEDTPKVAGSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NEF_SIVML
Sequence: MGGAISMRRSKPAGDLRQKLLRARGETYGRLLGEVEDGSSQSLGGLGKGLSSRSCEGQKYNQGQYMNTPWRNPAEEKEKLAYRKQNMDDIDEEDDDLVGVSVRPKVPLRAMTYKLAIDMSHFIKEKGGLEGIYYSARRHRILDMYLEKEEGIIPDWQDYTSGPGIRYPKTFGWLWKLVPVNVSDEAQEDERHYLMQPAQTSKWDDPWGEVLAWKFDPTPAYTYEAYVRYPEEFGSKSGLSEEEVRRRLTARGLLNMADKKETR
What is the function of this protein?
Interferes with TCR signaling from the cell membrane.  Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: NP24_SOLLC
Sequence: MGYLTSSFVLFFLLCVTYTYAATIEVRNNCPYTVWAASTPIGGGRRLNRGQTWVINAPRGTKMARIWGRTGCNFNAAGRGTCQTGDCGGVLQCTGWGKPPNTLAEYALDQFSNLDFWDISLVDGFNIPMTFAPTKPSGGKCHAIHCTANINGECPRALKVPGGCNNPCTTFGGQQYCCTQGPCGPTELSKFFKKRCPDAYSYPQDDPTSTFTCPGGSTNYRVVFCPNGVADPNFPLEMPASTDEVAK
What is the function of this protein?
Has antifungal activity against P. betae and F. dahliae.  May be involved in disease resistance in tomatoes and/or have a possible role in fruit development and ripening.
What are the official names of this protein?
Protein NP24, Pathogenesis-related protein PR P23, Salt-induced protein.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Or soluble fractions of cytoplasmic organelles, except mitochondria and plastids.
Protein: GET1_CANAL
Sequence: MLLPDLHPYTILLSIFLVLVAKQLVATIGKSTIQEFVWLVYLKVSSNQSIKTYNSKQHELHETNRQKRAISAQDEYAKWTKLNRQADKLSAELQKLNQEIQQQKSSIDKASNALILVLTTLPIWIARVFYRKTHLFYIRQGIFPKYVEWVLALPFLPNGAVGLTIWMFAVNSVVSNFSFLVSFPFAKRVSKPVRDTKVE
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
What are the official names of this protein?
Golgi to ER traffic protein 1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: YOBD_SHIBS
Sequence: MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRIPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLVSGNAANLLI
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BOLA2_MOUSE
Sequence: MELSADYLREKLRQDLEAEHVEVEDTTLNRCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPHIHAFEQKTLTPEQWTRQRRE
What is the function of this protein?
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins.  Acts together with the monothiol glutaredoxin GLRX3.
What are the official names of this protein?
BolA-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the BolA/IbaG family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSBU_CROS5
Sequence: MKTIVRLFAILMVLISSVGFVGSAVAAELNPVDAKLTTEYGQKIDLNNEDVRGFRQLRGFYPNLAAKIIKYSPYDSVEEVLDIPGLSERQRQRLEANLDKFVVTPPSSELNEGGDRINPGLY
What is the function of this protein?
Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation.
What are the official names of this protein?
Photosystem II 12 kDa extrinsic protein, PS II complex 12 kDa extrinsic protein, PSII-U.
What is the protein family that this protein belongs to?
Belongs to the PsbU family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: BPA_MYCBO
Sequence: MVIGLSTGSDDDDVEVIGGVDPRLIAVQENDSDESSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLRDIHATSIRELEDGLAPELREELDRLTLPFNEDAVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLQQMRQGALPPGVGKSGQHGHGTGQYL
What is the function of this protein?
Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif).  Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction.
What are the official names of this protein?
Bacterial proteasome activator.
What is the protein family that this protein belongs to?
Belongs to the Bpa family.
Protein: RPIA_BURMS
Sequence: MTQDELKRLVGEAAARYVTENVPQGAVIGVGTGSTANCFIDALAAVKDRYRGAVSSSVATTERLKSHGIKVFDLNEIESLQVYVDGADEIDGSGAMIKGGGGALTREKIVASVAETFVCIADASKRVAVLGQFPLPVEVVPMARTAIGRRLAALGGVPVLRVKQDGAPYVTDNGNEILDVKGLRIDDPRALEAAINGWPGVVTVGLFAQRGADLCLLGTERGVETLRYAAH
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: KDSB_CHRVO
Sequence: MNGFTVVIPARMASSRLPGKPLADIAGKPMVVRVAEQAAKSRAARVVVATDHADILAACAAHGVEAVLTREDHASGTDRLAEVAAKLALPDDALVVNVQGDEPLIQPELINRLAELLAGADAPVATLAHALHDAADHFNPNVVKVALDKHGRALYFSRAPIPYARDAYAADRSALPAGLPVYRHIGMYGYRAGFLAAYAGLEPGPLEQYEALEQLRVLWHGYGIAVALADEAPAAGVDTPEDLERVRRLFA
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTPAL_STAAC
Sequence: MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIFINQKISGLNKTDQSNLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLTKEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIKGKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKFQNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKDTEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTTREFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKNIKTIKIGLSALGYKVDNESTQFDKALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEKANKHDDVLDKLINILK
What are the official names of this protein?
Probable CtpA-like serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S41A family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FEN1_PENRW
Sequence: MGIKHLYQVISENAPDAIKTGEIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRVARKAEATEAHEEAKETGTAEDIEKFSRRTVRVTREHNAECKKLLELMGIPFINAPTEAEAQCAVLARAGKVYAAASEDMDTLCFESPILLRHLTFSEQRKEPIQEIHLDRALEGLDMDRAQFIDLCILLGCDYLEPIPKVGATTALSLIKEHKSLEKVLEFMKNDPKKKFVVPEDWPYEDARELFTNPDVRPADHPECDFKWEAPNVEGLIEFLVGDKGFNEDRVRNGAARLSKHLKTAQQSRLEGFFKPVARTEDEKASLKRKHDEKLQQQKKKKKEDAKAKKEAKAKPRGAA
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: US16_HCMVA
Sequence: MGLRFPTATQRQIVFRRLFDSGNNDDYDEAAVVAVLGWVHRFEVVVRIAGLLLFQISAAVAVLGSFSLVFPTATLKSRPGFPCHVVWAPEVLLLVPVASALFVYFRYERPVLAQRNRHPRCRRPFRQLVLLLAGLLAHIPALGVTCACQEPREVLTSFVLTLVITLLCAEVVFICRDNCTLSDQFTLINGVWVVVFLVNVLIVFTRPWTWPLRLLLGFYSTVGLIFAGHFSQQVLFVRHVLMPRDVAHTSLQLFITFISLFFLILRIRNCQDLLSDLRLLELPSSDAMTLTPNDLSHASSSTPLSTLSP
What are the official names of this protein?
Uncharacterized protein HVLF2.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US12 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMG_ANAPZ
Sequence: MQNYDVVVVGGGHAGCEAAAAAARVGAKTLLVTHKVESIGEMSCNPAIGGIAKGVVVREVDALDGLMGKVIDKSSIHSIILNRSKGPAVWGPRAQADREVYKPTMRDMVLHYENLTVISEEVVDFTVDGVEERPQISSVLLSNGELIKTTRLVFATGTFLGGTIHVGNESFPAGRIGDKPSTKLPQALTAHGFQLGRLKTGTPPRIDRDSINWSKLLEQKGDVLPTPFSFMSECVSLPQISCYVTHTNEKTHEIIRRNLHLAGSRCESLLDVMAPRYCPSIEEKIRRFPDHKSHQIFLEPEGLETNSVYPNGISTSCPIEVQLEMLRSINGLEQAVMLRHGYTVEYNFIDPRELYHTLETKKIKGLFCAGQINGTTGYEEAAGQGIVAGANAALSLVQNQEPLVLKRSDSYIGVMIDDLVTLGTSEPYRLFTSRAEYRLTLRSDNADMRLTEIGRAYSLVSQERFDRLSQKKQEMHALLNALKGIVATPNDIAEYDIAIAQNGEKKNAFELLSHPNINMEVLLKIWPSLRSFSAGTLALMEIEGKYAPYLKRQEADIKSFLEEENLSIPKDILYSDVYGLSKEAQEKLQAVKPFSIGAARRIPGITPAAIANILIHLRCKHKSSHKSL
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1636_STAAE
Sequence: MNTFQMRDKLKERLSHLDVDFKFNREEETLRIYRTDNNKGITIKLNAIVAKYEDKKEKIVDEIVYYVDEAIAQMADKTLESISSSQIMPVIRATSFDKKTKQGVPFIYDEHTAETAVYYAVDLGKSYRLIDESMLEDLKLTEQQIREMSLFNVRKLSNSYTTDEVKGNIFYFINSNDGYDASRILNTAFLNEIEAQCQGEMLVAVPHQDVLIIADIRNKTGYDVMAHLTMEFFTKGLVPITSLSFGYKQGHLEPIFILGKNNKQKRDPNVIQRLEANRRKFNKDK
What are the official names of this protein?
UPF0354 protein NWMN_1636.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: RS11_PROM0
Sequence: MPATVKKTGSKKSKRNVPNGVVHIQSTFNNTIVSITDTSGHVISWSSAGASGFKGARKGTPFAAQTAAEAAARRALDQGMRQIEVLVRGPGAGRETAIRALQVAGLEITLIRDVTPLPHNGCRRPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ACKA_LEIXX
Sequence: MSAVLVVNSGSSSLKYQLIDAKSEEALATGLIERVGEGEGRIRHRGPGGSAEYTLVIPDHTAAFRAMLAAFGTDGSSLVEHPLDAVGHRVVHGGKRFFEPTIVTPLVEANIDDLADLAPLHNPANLDGIRAARQAFPAVPHVAVFDTAFHQTLEPAAYTYAIDAALAEEHRVRRYGFHGTSHKYVSGAVAELLGRPLGELKQIVLHLGNGASACAVDGGRSIDTSMGMTPLEGLVMGTRSGDIDPAVLFHLSRRAGLGIDELDELLNRRSGLLGLTGHGDMRDVRRVAESGDAVARLALDTVAHRLKHYIGAYTALLGGLDALTFTAGVGENDPDLRAAACKGLGVLGIQLDPERNAARSPGARIVSADGSPVTVLVVPTNEELEIARQALQAVAAG
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSMR_HUMAN
Sequence: MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC
What is the function of this protein?
Associates with IL31RA to form the IL31 receptor.  Binds IL31 to activate STAT3 and possibly STAT1 and STAT5.  Capable of transducing OSM-specific signaling events.
What are the official names of this protein?
Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: XYLA_FERGO
Sequence: MYFNVEKVVYEGPSSKNLLAYKFYNPEEEIAGKKMRDWFRFAVAYWHTFNSRGEDPFGSATFERPWFKKDPMDTAFAKVDALFEFCEKTGVEYFTFHDRDLAHEGLTLRESNKILDKVVEKIKEYMKSSNVKLLWGTANLFSHPRYAQGAATSPNPLVFSYAASQVKKMLDVTKELGGLGYVLWGGREGYDNLLLTDSALEEKLFARFLEMVVEYKERIGFNGVLMIEPKPKEPTKHQYDFDASTVLYFLKKHNLFEHFKLNIEANHATLAGHTFAHELRVARLNGKLGSIDANRGDLLLGWDTDQFPTDVYETTFAMYEVLENNGLDCGFNFDAKVRRASIDPEDIVYAHVSSMDAFALGLKLAVKLREKVKPMIEERYSEYNSEIGMKILEGKTTLDELSSYVEDLTDVRVKSLKQELLEMVINDVIFGGR
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.