PharMolix/UniProtQA huggingface dataset:
Protein: GL_PSHV1
Sequence: MRRSAARGRAVSSTQTAMGAGAAIAVWAAALIALYSSCAAQTAPKTSSLRAANASDTIGRLIDGAEQLVSMRCMTSFEHEAAVTLYGPEYTPGGSMFEDLLTIIFKPQCSPPEAILWYKSGTAVRVNPYYLCRILVLALQGNPRGEVKFVVSRLIAEHAGGPLVRWPTTNVLRPEKTAPGGV
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: Y155A_MYCTU
Sequence: MGESKSPQESSSEGETKRKFREALDRKMAQSSSGSDHKDGGGKQSRAHGPVASRREFRRKSG
What are the official names of this protein?
Uncharacterized protein Rv1155A.
Protein: PHTF1_RAT
Sequence: MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGFKNKPKKMGHIKPDLIDVDLIRGSTFAKAKPEIPWTSLTRKGLVRVVFFPLFSSWWIQVTSLRIFVWLLLLYLMQVTAIVLYLMMPIVSVSEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRKLRKTVNGDGTRDNGNNSPDKIRAVETLDSAPSVGGFWGTLFGNRIKRVKLVSNKGTETDNDSGCFHPIIKKRQGRPEIRMWQAREKAKVSDGEKCRREAYRRLGNGVSDDLSSEEDGEARTQMILLRRSVEGASSDNGCEVKNRKSILSRHLNSQVKKTATRWCHIVRDSDSLAESEFESAAFSQGSRSGMSGGSRSLNLSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGAHVNTLHSGTKRDPKEDVFQQNHLFWLQNSSPASERVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYEQGVGYQMLGNAVTIGLALFPFLYRLFREKSFDQLKSISAEEVLTLFCGAPPVTPVVILSIINFFERLCLTWIFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLRLASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS
What are the official names of this protein?
Protein PHTF1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Protein: RL1_CLOBH
Sequence: MGKKYTESVKLVDKNTLYTVQEAIELVTKTSKAKFDETVELAVRLGVDPRHADQQVRGAVVLPHGTGKTVRVLVFAKGDKVNEAQEAGADFVGAEELVEKIQKENWFDFDVVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIADIKAGKVEYRVDKTAIIHVPIGKSSFGEEKLSDNFHVLMEAVVKAKPAAAKGQYIKSVAISSTMGPGIKINPGKVLE
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: FUMA_ECOLI
Sequence: MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRCVK
What is the function of this protein?
Catalyzes the reversible hydration of fumarate to (S)-malate.  Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle.  Accounts for about 80% of the fumarase activity when the bacteria grow aerobically.  To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate.  Can also catalyze the isomerization of enol- to keto-oxaloacetate.
What are the official names of this protein?
Fumarate hydratase class I, aerobic, Fumarase A, Oxaloacetate keto--enol-isomerase, OAAKE isomerase, Oxaloacetate tautomerase.
What is the protein family that this protein belongs to?
Belongs to the class-I fumarase family.
Protein: Y2028_SULIK
Sequence: MDYWFAEIVTIGNEVLSGKTVNTNASHIGRRLTSLGFTVRRITVVMDDIDEIVSAFREAIDRKPKVIVSSGGLGPTWDDKTAEGLAKALGVNLELNKTAFDMILEKYTKRNIPLTEERKKMAYLPYGAMAVENNEGIAPGIYIYHNNIDILATPGVPREMENVLENFINKMLRNKPNLKYLEDFIYVENVMESALAPYVKELVKKYDIYIKTHPKSYELLRPILEIQIAGSGREEEIKVKIEKVKNELLDAIKKLNGIIRNSL
What are the official names of this protein?
Protein M164_2028.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: KPCL_RAT
Sequence: MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCTNVSDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAGTSDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLISRSTLRRQGKEGSKEGNGIGVNSSSRFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFFKEIDWVQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP
What is the function of this protein?
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells.  In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation.  Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes.  In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation.  In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement.  Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs.  In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation.  Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1.  Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation.  In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.  Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.  Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization (By similarity).
What are the official names of this protein?
Protein kinase C eta type, PKC-L, nPKC-eta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_CAMJJ
Sequence: MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENLGAKVNFQNNSALLNTNTLNQTIAKYDIVRKMRASILTLGPLLARFGHCEVSLPGGCAIGQRPIDLHLLALEKMGANIQIKQGYVVASGNLKGNEILFDKITVTGSENIIMAAALAKGKTKLLNVAKEPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLEFKEFSVIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVLAKLHQMGFETLITEDSITLLPAKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTSIIDERLFENRFMHVSELLRMGADIKLNGHIATIVGGKELNAADVMATDLRASSALILAALAAKGTSKVHRIYHLDRGYENLEEKFKDLGAKITRLEE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_PSEMY
Sequence: MLVLGLETSCDETGVALYDSERGLLADALFSQIDLHRIYGGVVPELASRDHVKRMLPLIRQVLDEAGREPSDIDALAYTAGPGLVGALLVGASCAQALAFAWGVPAVGVHHMEGHLLAPMLEEQPPAFPFVALLVSGGHTQLVRVDGIGQYQLLGESLDDAAGEAFDKTAKLMGLNYPGGPEIAKLAEQGTPGRFVFPRPMTDRPGLDFSFSGLKTFALNTWQQCRDSGDDLDQARRDIALAFQQAVVETLTIKCKRALKQTGLNSLVIAGGVSANKALREHLERMLGELKGKVFYARPRFCTDNGAMIAYAGCQRLLAGQHEDLAIKVQARWPMESLPAL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_BORBU
Sequence: MHEVRVLAFQKIYSIDINQSAMDDIFDIFNIEDKDLDIENESIKSFYSSLVIGTFDNLEHIDSLIRDISLNWSLERMDKVDLAILRMGVYSLKFQNFENSKRAIIDEAILIAKKYGSKNSYKFINGILDALLKNMESGIEKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: HIS82_CARHZ
Sequence: MVRKALENLKPYVPGKPVEEVERELGITNIDKLASNENLWGISPKVAAAIKEAVDKVNYYPDGGAFRLKEKIAAKYGVTPDNIILGNGSDELVMFLAMALIDPGDEAIMPVPSFPRYEPVVTMMNGIAREIPLKEHRLDLKTMAEAVNEKTRLVYLCNPNNPTGTYITKGELEEFLERVPEEVVVVLDEAYFEFARLFNDYPDGLNFFKKRPNTVVLRTFSKAYGLAGLRVGYGFAPENLAKAINSLRPPFNVNFLAQMAAVAALDDEEYVREVVKNTDEGKKFLYQEIIRMGLSYIPSAANFLMIKTEKPSALVFRELLKRGVIVRSGDIFGMDDWIRVTVGTPVQNARFINELKMVLEIL
What are the official names of this protein?
Histidinol-phosphate aminotransferase 2, Imidazole acetol-phosphate transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: REX_LYSSC
Sequence: MKQELKIPQATTKRLPLYYRFIQNFAQEGMERISSKELSEAMKIDSATIRRDFSYFGALGKKGYGYDVQHLLQFFSQTLDQHETTKVALIGVGNLGSALLKYNFQKNHNTHIVVAFDSKAPKDGKMISNIPVFHPDLLEEKYAEYGAELAILTVSPRSAQKMADRLAAMNAKGILNFTPERLTVPDSMQLLTIDLSVELQALIYLIRNQEV
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R1B19_SOLDE
Sequence: MNFNNELSDLKNRFLFRTLRVQEYSDVARDRIDFFIWELKFLNCVLHLQSFTFASECGMLDISQKMLEICKRFNTPPPHNAFAYWKEVICKRLCAISIRPDASSDDGFACWKKVIWKTKQEFRAKYSFPKTLLADNKVYDDTNPKFVMEFIDAVVGNLNVLVKINDPSSLHFVPGPKEQIEQVLKELKLLRFFVCFVSNKCTEPQYQYTTFYTHALIEASHIAMVVWLNLPIYGNRNQDLASNEVSCLFSDFMEMKIKSIQPGISRNNIYINVLRALKSTIPHAQDKHAAESGIVETPTHNLMVGLSDQMANLQEMLCLLRDNLIHLPILDLEFHLQDMDSVILDVGLLIYSFYDMKGEKEDTTLEDINRELGFDLPRNIEPIKAMVYLVMQKAFHCNLPRVHGLGYADFLLKNLKDFQGRYSDSLAFLKNQLQVIQTEFESLQPFLKVVVEEPHNKFKRLNEDCAIQIIRKAHEVEYVVDACINKGIPHWCLERWLQDIIEEITCIKAKIQEKNTVDDTMKTVIVRTSSKLARTPRMKEEIVGFEDIIENLRKKLLNGTKGQDVISIHGMPGLGKTTLANRLYSDRSVVSQFDICAQCCVSQVYSYKDLLLSLLCDTIGEESERRELPDNELADMLRKTLLPRRYLILVDDVWENSVWDDLRGCFPDTNNRSRIILTTRHHEVAKYASVHIDPLHLRMFDENESWKFLEKNVFGEESCSPLLRDVGQRIAKMCGQLPFSIVLVAGIPSEMEKEVECWEQVANNLGTRIHNDSRAIVDQSYHVLPCHLKSCFLYFAAFLEDVVIYISRLLRLWISEAFIKSSEGRSLEDIAEGYLENLIGRNLVMVTQRADSDGKVKTCRLHDVLLDFCKKRAAEENFLLWINRDLITKPFSCVYSHKQHAHLAFTEMHNLVEWSASCSFVGSVVLSKKYEPYFSIDLYSFYDFAISRNLPNFKFLKVLDLEHQVFIDFIPTELVYLKYFSAHIKQNSIPSSIYNLWNPETLKLKRPRHVRRCTLLLPSTVWDMVKLRHLYIPDFSTENEEALLENSAKLYDLETLSTPYFSRYHVLNFPIRLEILKLYRSKAFKTIPFCISAPNLKYLKLSGFYLDSQYLSETADHLKNLEVLKLYYVEFGDHREWKVSNGMFPQLKILKLEYLSLMKWIVADDAFPNLEQLYIKVENCNELVVKSAMNIQETQVEDNQNTNFKLVLIEKKTLKLNLSHDEDIPKAFKRLFLCPGIESVSTDRKEKKLTVTGDVDAGSSISCGETEKAWHARVVVPTCQHKCGIVILLTSNELGLGREERKKRRKRRKRRAIKEIIVDIVGGDPY
What is the function of this protein?
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
What are the official names of this protein?
Putative late blight resistance protein homolog R1B-19.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: TRPB_NOVAD
Sequence: MTAQTPNSFRNLPDERGHFGQFGGRYVAETLMPLILDLEREYNAAKADPAFKAEFDDLLEHYVGRPSPLYFAPRLTEELGGAQVWFKRDELNHTGAHKINNCIGQILLAMRMGKTRIIAETGAGQHGVATATVCARFGLPCVIFMGATDVARQAPNVFRMKLLGAEVVPVTAGAGTLKDAMNEALRDWVANVHNTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLSRTGRLPDLLVAAIGGGSNAIGLFHPFLDDPSVRMLGVEAAGHGLDKEHAASLAGGRPGILHGNKTYLLQDEDGQITEGHSISAGLDYPGIGPEHAWLKEIGRVDYTSVTDTEALDAFQLLCRTEGIIPALEPAHAIAAVKKVAPTMGKDEIILANLCGRGDKDIFSVAEHLGVSL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RL19_PELPD
Sequence: MNTIDFLEFEQMKKNVAPFKVGDTVKVQVKIVEGDKQRIQAYQGVVISRQNGGIRESFTVRKISNGIGVERIFPLHSPILETVEIVTRGHVRRAKLYYLRKLRGKAARIREKKYVPIAK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YFCE_ECOLI
Sequence: MMKLMFASDIHGSLPATERVLELFAQSGAQWLVILGDVLNHGPRNALPEGYAPAKVAERLNEVAHKVIAVRGNCDSEVDQMLLHFPITAPWQQVLLEKQRLFLTHGHLFGPENLPALNQNDVLVYGHTHLPVAEQRGEIFHFNPGSVSIPKGGNPASYGMLDNDVLSVIALNDQSIIAQVAINP
What is the function of this protein?
Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p-nitrophenylphosphorylcholine (pNPPC).  The physiological substrate is unknown.
What are the official names of this protein?
Phosphodiesterase YfcE.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. YfcE family.
Protein: RS11_ACHLI
Sequence: MAAQKRKTTKRRVRKNIPSGIAHIHTTFNNTIVTITDPAGNAISWSSAGALGIKGSRKSTPFAAQLTSEAAAKGAMDNGMARVEVYVKGPGPGREAAIRSLQAAGLEITAIKDVTPVPHNGCRPPKRPRN
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TGT_CLOBH
Sequence: MYKLLKKSGKARRGEFTTPHGVIQTPVFMNVGTLAAIKGAVSSMDLKEIGCQVELSNTYHLHLRPGDEVVKKMGGLHKFMNWDRPILTDSGGFQVFSLSKIRKIQEEGVYFNSHIDGRKIFMGPEESMRIQSNLASTIAMAFDECVENPAPREYVEKSVERTTRWLHRCKDEMNRLNSLPDTINNKQMLFGINQGGTYEDIRIEHAKTIAKMDLDGYAIGGLAVGESHEDMYRIIDAVVPHLPEDKPIYLMGVGIPSNILEAVDRGVDFFDCVLPARNGRHAHVFTKEGKINLLNAKFELDDRPIDEGCQCPACKHYTRSYIRHLFKAKEMLAMRLCVLHNLYFYNNLMEEIRDAIDGNYFKEYKERKLKEWGGRA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: LIPA_SHEB9
Sequence: MNRPERLQPGVKLRDADKVSRIPVKIVPSERDTMLRKPDWLRVKLPASNQRILEIKQALRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPLKPDAEEPVKLAQTIRDMKLKYVVITSVDRDDLRDGGAQHFADCIREIRKLNPDIKIETLVPDFRGRIDAALDILSTEPPDVFNHNLETAPMHYRKARPGANYQWSLDLLKRFKERHPNVPTKSGLMMGLGETNEEIAQVLRDLRAHNVEMLTLGQYLQPSKFHLPVERYVPPAEFDELKALADELGFTHAACGPLVRSSYHADLQAQGKEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PSEMY
Sequence: MENLDALVSQALEAVQQSEDVNALEQLRVQYLGKKGELTALMQTLGKLSAEERPQAGALINTAKNQVQDALNARKSVLEQALLAEKLASERIDVTLPGRGQTSGGLHPVTRTLERVEQFFTHIGYSVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRCDSDITHSPMFHQVEGLLVDEGISFADLKGTIEEFLRVFFEKPLGVRFRPSFFPFTEPSAEVDMQCVMCSGKGCRVCKQTGWLEVMGCGMVHPNVLRMSGIDPEKYSGFAFGMGVERLAMLRYGVNDLRLFFDNDLRFLAQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED7A_ARATH
Sequence: MATATYPPPPPYYRLYKDYSENPNSAPEPPPPIEGTYVCFGGNYTTEDVLPSLEEQGVPQLYPKDSNLDYKNELRSLNRELQLHILELADVLVDRPSQYAKRIGEISSIFKNLHHLLNSLRPHQARATLIHIMELQIQQRKQAVEDIKRRREEAQRLLKDAYLTLDGQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7a.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPA43_MOUSE
Sequence: MAAGSVESQRSQAASERPVAGQAGVLPCLELPSYAAACALVGSRYSCLVAAPHRRHIALSPRYLSRKRTGIREQLDAELLRYSESLLGVPIAYDNIRVVGELGDIYDDQGHIHLNIEADFVIFCPEPGQTLMGTVNKVSSSHIGCLVHGCFNASIPKPEQMSYEEWQTLEIHVGDELEFDVFRLDSDSAGVFCIRGKLSTTSLQLKHSAVSEDVAETVVEEVVEKTPKKKKKKKDKDTDTCGTVDSVTEVADVTDVTPQEETDIPCSDNVNDFFEEEPKKKKKKKKRHQEDQDPIFQASDSSGYQSDHNKKKKKRKHSEEANFESPKKRQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase I which synthesizes ribosomal RNA precursors.  Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA43, DNA-directed RNA polymerase I subunit F, Twist neighbor protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NUOA_ANASK
Sequence: MLTPLQIYFPIGVVLLVAVVLAFTMLGLANVLGPRRPSLVKQTPFECGSEPVGSARERFGVKFYVVALLFIVFDIEAIFLYPWAVLLLPDGQGYPGLGWPGFVSMGIFVFTLVAGLVYVWKKGVLDWAD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.