PharMolix/UniProtQA huggingface dataset:
Protein: XCT_PONAB
Sequence: MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGSVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL
What is the function of this protein?
Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity).  Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity).  The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine.  In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis.  Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis.  In vitro can also transport L-aspartate (By similarity).  May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons.  Controls the production of pheomelanin pigment directly (By similarity).
What are the official names of this protein?
Cystine/glutamate transporter, Amino acid transport system xc-, Solute carrier family 7 member 11, xCT.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VPC12_MYCTU
Sequence: MIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFTQRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  The cognate antitoxin is VapB12 (By similarity).
What are the official names of this protein?
Ribonuclease VapC12, RNase VapC12, Toxin VapC12.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: RL25_BUCAP
Sequence: MFIVKAEIRDKKGKSFSRKLRIEDKFPGVLYGFNNTPISITMDHNLVFNLQKKEDFYKETLCLLIKEKKYTVKVHAIQRHAFKMKILHIDFIYAKI
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: HBPL_PARAD
Sequence: MSSSEVNKVFTEEQEALVVKAWAVMKKNSAELGLQFFLKIFEIAPSAKNLFSYLKDSPVPLEQNPKLKPHATTVFVMTCESAVQLRKAGKATVKESDLKRIGAIHFKTGVVNEHFEVTRFALLETIKEAVPEMWSPEMKNAWGVAYDQLVAAIKFEMKPSST
What is the function of this protein?
Provides oxygen to the bacteroids.  This role is essential for symbiotic nitrogen fixation.
What are the official names of this protein?
Non-legume hemoglobin.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: ATNG_XENLA
Sequence: MADAQDDMSQMQDKFTYDYETIRKGGLIFAAIAFVVGMLIIFSGRFRCGRKKQLRALNDDM
What is the function of this protein?
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit gamma, Na(+)/K(+) ATPase subunit gamma, FXYD domain-containing ion transport regulator 2, Sodium pump gamma chain.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: RUVB1_CANGA
Sequence: MVQITEVNESKAGTANRTAAHTHIKGLGLDDTGAARQVEGGFVGQVEAREACGVIVDLIKAKKMSGRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTETLMENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYDSIQKEKVSIGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDIANARPQGGQDVISMMGQLMKPKKTEITEKLRFEVNKVVAKYVDQGVAELIPGVLFIDEANMLDIEIFTYLNKALESDIAPIVVLASNRGMTTVRGTEDVISPHGIPADLIDRLLIVRTLPYNKDEIRLIIERRSAVENLALEDGALDILADMATHTSLRYALQLLSPAGILSSTAGRQKITIDDINEAKMLFIDAKRSTKILENSDRYM
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPSB_STRPN
Sequence: MASIIFSAKDIFEQEFGREVRGYNKVEVDEFLDDVIKDYETYAALVKSLRQEIADLKEELTRKPKPSPVQAEPLEAAITSSMTNFDILKRLNRLEKEVFGKQILDNSDF
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: SSB_RHIME
Sequence: MAGSVNKVILIGNVGADPEIRRTQDGRPIANLRIATSETWRDRNSGERREKTEWHTVVVFNEGLCKVVEQYVKKGAKLYIEGQLQTRKWQDQTGNDRYSTEVVLQGFNSTLTMLDGRGGEGGGAGRGGSDYGGGGYEEYDQSRPSSGGARSGGQSNQPNQGGNFSRDLDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: SYDP_PECAS
Sequence: MEHEVVSALAAFTQRYVACWQQEKGHLPASEALYGIPSPCIVENHEDTVYWSPQPFAPSVALDGVERALEISLHPDVHAFYTAQYAGDMAAQFDSLSCQLLQVWSEEDFTRMQENLIGHLLTQKRLKLTPTLFLATTDSEMTMVSLCNVSGEIVLEAFGTKKRQHLAPTLAAFLSGLNPLAV
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: RPP30_BOVIN
Sequence: MAVFADLDLRAGSDLKALRGLVENAAHLGYSVVAINHVVEFKEKKQEIEKPVAVSELFTTLPIVQGKSKPIKILTRLTIIVSDPSHCNVLRATSSRVRLYDIVAVFPKTEKLFHVACTHLDVDLVCITVTEKLPFYFKRPPINVAIDRGVGFELLYSPAIKDSTMRRYTISNALNLMQVCKGKNVIISSAAERPLEIRGPYDVANLGLLFGLSESDAKAAVSTNCRAVLLHGETRKTAFGIISTVKKPRTSEADDDSLPACKKAKCES
What is the function of this protein?
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.  Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
What are the official names of this protein?
Ribonuclease P protein subunit p30, RNaseP protein p30, RNase P subunit 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RF1_BURVG
Sequence: MKTSMQRKLDQLSVRLAELNDLLSRENVTADLDQYRKLTREHAELGPVVEQYALWRQSRNDEAAAQELLADASMRDFAEEAIRSARERMTRLEGELQKMLLPKDPNDDRNIFLEIRAGTGGDESALFAGDLLRMYLRYAERQRWQVEMMSESPSDLGGYKEVIVRIAGQGAYSRLKFESGGHRVQRVPATETQGRIHTSACTVAVMPEADEIGEVEINPADLRIDTFRASGAGGQHINKTDSAVRVTHIPTGIVVECQDDRSQHKNKDRALKVLAARIKDKQYHEQHAKEAATRKSLIGSGDRSERIRTYNFPQGRMTDHRINLTLYRLEALMDGDLDELIGALVSEHQAELLASLGDAD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIP_RAT
Sequence: MAAGLLPSARAVLALLFLGLALLSVGPAPAQALHNVTAELFGGEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQSAPYFKPKVKVSLKNFSALVTSVVPGDYDGDSQMDVLLTYFPQNHSNNELGAVIFWGQNQTLDPKNMTILNRTFHDQPLIMDFNGDLIPDVFAITNESSQPQILLGGDLSWHPALTTKSKMRDPHSRAFIDLTEDFTADLFLTTLSASNTFQFEIWENLGGNFSIRSVFEKPKNLVVVGQSAFADFDGDGHMDHLLPGCEDKDCQKSAIYLMRSGTGQWAPVLQDSSNKGTLWGFVPFVHEERPTAIPVPLTLHIGDYNMDGYPDALAILKNTSGSNQQAFLLENVPCNNASCEEVHRMFKVYWDLAGLNLIKDAMVATFFDIYEDGTLDIIVLSKGYTKSDVAIHTLKNNFEADAYFVKVIVLSGLCSSDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAHLALQLPYNVLGLGRSANFLDHLFVGIPRPSGEKSIRKQEWTAIIPNSQLMVIPYPHSVPRSWSAKLYLTPSNIVLLTAVALTGVCVFILAIIAILHWQEKKADDREKRQEAHRFHFDAM
What is the function of this protein?
Modulator of T-cell function.  Has a protective effect in graft versus host disease model (By similarity).
What are the official names of this protein?
T-cell immunomodulatory protein, Protein TIP, CDA08-like protein, Integrin-alpha FG-GAP repeat-containing protein 1, Linkin.
What is the protein family that this protein belongs to?
Belongs to the TIP family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Single-pass type I membrane protein.
Protein: KAE1_YEAST
Sequence: MVNLNTIPPKNGRDYYIALGLEGSANKLGVGIVKHPLLPKHANSDLSYDCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDVICFTKGPGMGAPLHSVVIAARTCSLLWDVPLVGVNHCIGHIEMGREITKAQNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFARTLKIPNEPSPGYNIEQLAKKAPHKENLVELPYTVKGMDLSMSGILASIDLLAKDLFKGNKKNKILFDKTTGEQKVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDNRFCIDNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTDEVYAAWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, Kinase-associated endopeptidase 1, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, tRNA threonylcarbamoyladenosine biosynthesis protein KAE1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NET1_RAT
Sequence: MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSMEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIAXKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSXLVIQWRDTWARRXRKFQQREKKGKCKKA
What is the function of this protein?
Netrins control guidance of CNS commissural axons and peripheral motor axons.  Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively.  Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity).  Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity).  It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis.  Involved in colorectal tumorigenesis by regulating apoptosis (By similarity).
What are the official names of this protein?
Netrin-1.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Mainly secreted.
Protein: RUVC_PROM3
Sequence: MRILGIDPGLARVGYGVIDTSNGQQQMLDCGIIRTNPGIDDGVRMVEIASDLRQLIRRWKPQLAAVEKFFFYRSSTTISVVQARGVIIMTLARFRVPMVEFPPMQIKLALAGSGHAEKDEVLDAVMRELNLDQPPRPDDAADALAIALTGWFQR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: TTCA_SALAR
Sequence: MQDNQKVKKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIVRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQDIVPSHLCDTNLFDFKGIAHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTPLETLRLDVIEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1234_BREBN
Sequence: MLHTTIILLVIALLSLVAKDLVLVYASLLLLGLSLLKAVPVMDAIQKPMFHVGLFCLMVFLLIPIAKGKYDFISLGKEMVSWKATIAILAGFIISYVGGKGLSILPDQPVVFIGVTIGTLLAVLLSNGLPAGLIIAAGCIALLSRIFNF
What are the official names of this protein?
UPF0756 membrane protein BBR47_12340.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRF_BACC4
Sequence: MGQQVLKSSNEKMEKAVAAYSRELATVRAGRANASVLDKVQVDYYGAPTPVVQLANITVPEARLLVIQPYDKTSIGDIEKAILKADLGLNPSNDGTVIRIAFPALTEERRRDLVKVVKKYAEEAKVAVRNVRRDGNDDLKKLEKAGEITEDDLRGYTEDIQKETDKYIAKVDEIAKNKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_MYCPU
Sequence: MKSKTFLEKNFINVQAYKYNGDLYRQWNGSKIIKNDSQNIILYNFHSRIMEKSGKSWQVSEPSLWIFPKNENYNVNVLLRPEGNYYYINLTSPFIFEDNTIKYIDFDIDIKVYPKKEIEIVDIKEFQKNIKDYGYPPSVRKMVYKQVQNLLMFYEKQTSFFHRDFIDNIVNSLAKNKMLVFQSKKLSNFSQRYFEELRKNTKNEKIFKVYLCGPTVYDEVHIGNMRSVVVVDLIVRAQKYLGKKTLFVHNITDIDDKIIERSIQSKISENKISEKYFREYKKVLKKYRIKSIDKMPKVTDNIDSIVKFINSLDKKGYVIQKDDGFVFDVSKIKNYGKRLSREDKKQVENFYLWKSTTKGVQYNYNGFLGRPGWHSECTLFIDDIFNSQTLDIHAGGIDLTFPHHENENAQYIAKNDVKITKHWLHVGQVMFKNQKMSKSLGNVILAKDFDEDIFKIILINSSVTAPIYITNELIENAKVIINKYKKLYFKFLNLSLSFNFDDNVRYMVRKIADKDFSSFNLKLNEYIKAYNTSLEADKLTIVSSVIHFLNFSFIEQIEKDFRKNKKIYDIWQGFLKQKNYEKADMFRKILIDQGLI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_MALP2
Sequence: MSKNKLLLGSHVGFKAKNYLVGSVLETLEYDGNCFMVFTGPPQNFMRKELDQNLIDEAVKLMKEKNPLLLENIVVHAPYLINLGSPKESTRSLGLNQLIVEINRTNQIHSKLIVLHPGSALDSDRNVAINHIADNLNKAIEATDNDVIICVETMAGKGSEVGINFEEVSKIVSGVKNKKRIGVCLDTCHMHDSGIDISDPDQTLEEFSKYLDLSYIKVIHLNDSKNEIGSRKDRHDNIGYGKVGFDYLVKWAHNEKLANVPKILETPYRDDKPIYKQEIINLNSKEWKE
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: CH60_STRP4
Sequence: MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGIKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYISEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYILITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGAGNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQIAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVASLILTTEAVVANKPEPVAPAPAMDPSMMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CY552_NITEU
Sequence: MKTAWLGTFAASALLVAGYAQADADLAKKNNCIACHQVETKVVGPALKDIAAKYADKDDAATYLAGKIKGGSSGVWGQIPMPPNVNVSDADAKALADWILTLK
What is the function of this protein?
Monoheme c-type cytochrome.  Probable electron donor to membrane cytochrome oxidase and to periplasmic nitrite reductase.
What are the official names of this protein?
Cytochrome c-552, Cytochrome c-551, Cytochrome c552.
What are the subcellular locations of this protein?
Periplasm.
Protein: US15_HCMVA
Sequence: MRREKGFQVPTDGTVIYVPPGIQETRLATRSLAWVDCCRVALHTYGAVGWQLAGLTALLSAFCYAAPATWFHHSRLCLTESSPSLVFVIPVTSVIFIHCYETSHPSNIGVLLFYTLLHVPPLIVICLCLDGTLVISAALFTLLAFLSCTGVALLAPERTVRRQIVVVHALITLTFTAIVVVILRRGWSWCFKIVLSFSVLITCLAVSHFHEAALAVRYETPLERALLAAVKVFLSLVFTLLMVLRIMTLRTFLQTYFSSDKL
What are the official names of this protein?
Uncharacterized protein HVLF3.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US12 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THID_ECOLI
Sequence: MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW
What is the function of this protein?
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.  Shows no activity with pyridoxal, pyridoxamine or pyridoxine.
What are the official names of this protein?
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase, Hydroxymethylpyrimidine kinase, HMP kinase, Hydroxymethylpyrimidine phosphate kinase, HMP-P kinase, HMP-phosphate kinase, HMPP kinase.
What is the protein family that this protein belongs to?
Belongs to the ThiD family.
Protein: GPC1_XENTR
Sequence: MERLCWGWWWHLGILCLMHWAAGDTGSKTKSCSEVKQVYLAKGFSLNGAPQSEISGEHLRICPQGYTCCTSEMEENFANISRVEFEAKLRESSASIQRLLTTQHRNFDSYFQDLLNTSERVLQERFPSQYGDLYSQNSKIFRDLYSELRQYYRGSGINLEEALIEFWSRLLERVFKAQHTQYSFSEEYMDCLVKQYEQLKPFGDTPREVKLKAARAFIAARSFVQGLNAAADVVRKANQVPMSTECARAVMKLVYCPHCRGHSSIKLCSNYCWNVMRGCLANQADLDSEWRNLIESLLLVADKFNGASNVENIVGAIHTKISEAITHMQENKELLTNKVFKICGTPKKTNKGSKSEERRRKGKATQEDKSAVATMDNLISDVKGILSDIQDYWVSLPSLFCTEKVTAGPGNEDKCWNGITKGRYMPEPMGSGLANQINNPEVDVDITKPDMTIRQQIMQLKIMTSRLRNAYNGNDVDFQDTSDDMSGSGSGDGCNEDLCGSGRKLSRETVIIQPATHAVPRQPNPGETGKGTRLSSWDLLICLVALLVAQCTRW
What is the function of this protein?
Cell surface proteoglycan that bears heparan sulfate.
What are the official names of this protein?
Glypican-1.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
Protein: ATPG_CHLL3
Sequence: MPTLKDIRVRIKGVKSTQQVTKAMKMVAAAKLRKAQERAVMARPYAAKLKEMLGSLSGKVDTSASPLLADRADASRVLVVLITSDRGLCGAFNTNIIKLAHRTIHEEYAAAYAAGNVQLICAGTRGFDFFRKRGYSVLKGYPAVFQNLDFSTAREIAETASSMYVKGEVDRVVVVYNEFKSVLAPTLKAEVLLPIKSELPVAEGGDYIYEPSPAAIIEELVPKHLNTQVWGMMLESNAAEQAARMTAMDSATENAKELLRGLNISYNRARQAAITKELSEIVGGADALQN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WTR28_ARATH
Sequence: MMKEEQWAPVIVMLISSVAMGSVNALVKKALDVGVNHMIFGAYRMAISALILVPFSYIWERKTRPQLTFMLLCEHFISGLLGASLMQFFFLLGLSYTSATVSMALVSMLPAITFALALIFRIENAQNLKSKAGVLKVMGTLICIMGAMLLTFYKGPELSNPHSHPQARHNNNNNNGHDQTKKWLLGCLYLVIGTVLLSLWMLFQGKLSFKYPGNKYSSTCLMSVFASFQCAILSLYKSRDVKDWIIEDKFVILVTLYAGIVGQAMSTVVTSWSIKMTGAVFVSTFSPVSLVAATLFDFLILHSPLYLGSILGSVVTITGLYVFLWGRKNETDQSVSKTLNSSQFSQNKDNEDHTIANHKDTNLPV
What are the official names of this protein?
WAT1-related protein At4g01430.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.