PharMolix/UniProtQA huggingface dataset:
Protein: RED2_MAGO7
Sequence: MNTTGSAFVIGASGIGRACALAFARRGVSGLVVADVDLQAAESLAAECRAEAGSAGTADALGCAEATRVDVADERSVELAVSFARRVLGRVDYCVNSAGIGVKLANEIADASPVEFEAMFQVNVKGTFLVTRAVSALMKTQDPVPVLRDSPGRGTTRGCIVILGSAAAFAATPKMVQYTTAKHAVLGLTKSAALDNAAHGIRVNSVCPSWVDTPMVRRALQDVPELEQTIRTSVPMGRIALAEEVADAVMFLCSPGASYATGCNMILDGGTTLTTHLG
What is the function of this protein?
Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of pyriculol and pyriculariol, two heptaketides that induce lesion formation upon application on rice leaves but are dispensable for pathogenicity (PubMed:27902426).  The highly reducing polyketide synthase synthesizes the heptaketide backbone of pyriculol and pyriculariol (PubMed:27902426).  Pyriculol and pyriculariol contain several hydroxyl moieties and double bonds, so it can be assumed that several reduction steps occur during biosynthesis.  These reactions could be executed by PKS19 itself or partly by the tailoring enzymes OXR1, OXR2, RED1, RED2 or RED3, identified within the cluster (Probable).  The FAD-linked oxidoreductase OXR1 is the only tailoring enzyme for which the function has been determined yet, and is involved in the oxidation of dihydropyriculol and dihydropyriculariol into pyriculol and pyriculariol, respectively (PubMed:27902426).
What are the official names of this protein?
Short-chain dehydrogenase RED2, Pyriculol/pyriculariol biosynthesis cluster protein RED2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ATPG_LACDA
Sequence: MPASLLELKKRIASVKQTSKITEAMHMVSAAKLNQTEKRDKGYQEYNRLLHQTVSRLMSASVINHLNKANYRLTQDNIDSIDYDDVFGMGIISDMIKPREEVHSVGYLVVTGDRGLVGSYNSSVIKQMMSLVADDKLQGRESKILSVGSVGSQFFKKNNLNVVYEKDGVSDVPTFKETLPIVSTAIKMYLNGVYDELYVCYTHHVNSLSSAFRAEKMLPIVDLDIGTMEAKESKKIEFEVAPDIDSVLATLLPQFARAEIYGAILDAKTAEHASSMTAMKSATDNAKDLVSSLSLQMNRARQAQITTELTEIVSGANALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ISPE_SYNE7
Sequence: MKTLTLVAPAKINFYLEILGDRPDGFHELAMVMQSIALGDRLHLRQRQGQGFQLGCDRADLEVDERNLILKAAQRLQRSFPQIGGVDFFLEKRIPIGAGLAGGSTDGAAALVGLDIFSGLGLTQPELEAIAAELGSDMPFCVAGGTQLCTSRGEQLTPLPPLPSLSLVLAKFESLSVSTPWAYGRYREQFGDRYLQTEPARRDRLQALHAGPLLQAMSAGDPVAIAQHLRNDLEAVVLPEYPQVAELRSVLGNCSGILAAQMSGSGPSVFGIAENPTAAQAAVEQVRQAIADPDLKLWVTQTISHGIQTETLLR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: GAE2_ARATH
Sequence: MSHLDDIPSTPGKFKMMDKSPFFLHRTRWQSSVAKLAFWSLVFFGLLFIFFYRSPISNPDSSRRSLRTYSWGGPAWEKRVRSSARVRTRNGVSVLVTGAAGFVGTHVSAALKRRGDGVLGLDNFNDYYDTSLKRSRQALLERSGVFIVEGDINDLSLLKKLFEVVPFTHVMHLAAQAGVRYAMENPGSYVHSNIAGFVNLLEVCKSANPQPAIVWASSSSVYGLNTKVPFSEKDRTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFFTVYGPWGRPDMAYFFFTRDILKGKAISIFEGANHGTVARDFTYIDDIVKGCLGALDTAEKSTGSGGKKRGAAQLRVFNLGNTSPVPVTDLVSILERLLKVKAKRNMMKLPRNGDVPFTHANISSAQREFGYKPSTDLQTGLKKFVRWYLGYYKQGGKKVAAAA
What is the function of this protein?
Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.
What are the official names of this protein?
UDP-glucuronate 4-epimerase 2, UDP-glucuronic acid epimerase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
Protein: TBL5_ARATH
Sequence: MSTSSSFPRTIVSYTVTTSLFIVIFLCSVFFFTRRTLEPSLSPYHTADIPLPAVDLPPPTPLLPQIEPHDGDVTVETNPKEVEDSRRGGDDVAVETELKLKDVEDSHTEKTEEEEEGRGESPGEVSVESVEHAVIEKMRGCDLYKGSWVKGDDEYPLYQPGSCPYVDDAFDCQRNGRRDSDYLNWRWKPDGCDLPRFNATDFLVKLRGKSLMLVGDSMNRNQFESMLCVLREGLSDKSRMYEVHGHNITKGRGYFVFKFEDYNCTVEFVRSHFLVREGVRANAQGNTNPTLSIDRIDKSHAKWKRADILVFNTGHWWVHGKTARGKNYYKEGDYIYPKFDATEAYRRSLKTWAKWIDQNVNPKKQLVFYRGYSSAHFRGGEWDSGGSCNGEVEPVKKGSIIDSYPLKMKIVQEAIKEMQVPVILLNVTKLTNFRKDGHPSIYGKTNTDGKKVSTRRQDCSHWCLPGVPDVWNHLIYASLLLQPHS
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 5.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RSMG_NEIMB
Sequence: MERKERLRAGIAAMGLDISETAQDRLLVYVDLLKKWNKTYNLTALRDEEKMIVHHLLDSLTLLPHIEGVQTMLDVGSGGGQPGIPAAVCRPDVQITLLDANTKKTAFLQQAVIELGLDNVRVVSGRVEAVSDVRADVVTSRAFAELADFVSWTVHLLKDGGYWAAMKGVYPQEEIGRLPQDVCVEKVQRLDVPGLDAERHIVILSKR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_ACHLI
Sequence: MANIKSQIKRNLTNEKRHQANVSFKSSYKTAVKAVEKAVEAKDKDLALAKLSFAHKKLDKGQAKGIFHKNFVARNKSALARLVNSL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: BBE17_ARATH
Sequence: MKEVVYVLLLVLLVSVSDANETKPNIENFLRCLRNRTNPKNPIAEAIYTHENSTFASSYVSYTNNKRCLNPNDTKLIAIVAAKHESHVQATVVCAKSNGIQIRIRSGGHDYEGLSFTSSVPFVILDMHDLRSITIDVFRKQAWVDAGATMGELYTKIAAASKTLAFAGGVCPTLGAGGHISGGGYGNLIRKYGISVDHVVDARIVDVNGNILTGATLGRDLLWAIRGGGGASFGVILSWKINLVDVPKTVTVFKVNKTLEQGVTDVLYKWQLVSSKLPQDLFLRAMPKPVNGVVPSEKTIAVVFYAQFLGSARRLMAIMNKNLPELGLKREDCYEMSWINTTTFWQNYPVGTSTSVLLDRPSGPAGAFYKSKSDYVKKPIPKEEMEKIWKAMLKFNNMWMQWNPYGGVMDKIPADATAFPHRKGNLFKIQYFALWTDANATYANLGLMRDIYHEMEPYVSSNPREAFLNYRDIDVGSNPSGETNLEEAKIYGSKYFLGNFKRLMEVKAKYDPENFFRFEQSIPPASAM
What are the official names of this protein?
Berberine bridge enzyme-like 17, AtBBE-like 17.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RL25_AMOA5
Sequence: MKTIEIIGYRRANLGKQASKQLRNDAQVPGVLYGGKEQVHFYTPMAILKDLVYTPQAYFVTLNLEGAIYNCILQDIQFHPVNEVILHIDLLQIFEDKQIKMDIPIVLVGDAPGVVKGGNLVHKKKKLSVVAYPKDMPDTIPVDISGLDVGQMTRVSHIKAENYTILAVPGTPVAVVETTRALRAGAAEAEGKGKKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: BIOB_IDILO
Sequence: MPQIRNDWTIEEVQNLLQMPLNDLVFEAQTVHRQHFNPNEVQVSTLLSIKTGACPEDCKYCPQSAHYHTGLDRERLMAVESVLAEAQAAKEKGASRFCMGAAWRNPKDRDMPYVIEMIKGVKALGLESCMTLGMLSNEQAKMLQQAGLDYYNHNLDTSPEFYGDIITTRTYQDRLNTLNNVRDAGMKVCAGGIVGMGESVTDRASLLVQLANLPKHPESVPINMLVKVEGTPFAKLEDLDNFEFVRTVAVARILMPASHVRLSAGREDMNDEMQALCFLAGANSIFYGEKLLTTANPEADADLRLFERLGIKPEQRDGYDDEVHTAVIEDAIKEQQNPVRYYDAS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ELDP1_PINMG
Sequence: MFYLSTFMTIVISLSLVSCSYDCNNPGFTCHGECHYYGSCICNERLTGYDCSVLKSSLSTGSDCKVTCQNNGRCYDGNKCLCSSDYTGHLCEKQTTGARCTLDGVVFEAYRPIGFDGETYLSQSRSCKLLQSESDVPGMIKFERKIFHGDTSMCGLKKHMDMPNAGDITYEADIYSTFVYNSWGTRDFVDNVKCQYKPTRVGLSMDAPDSLFPIKMSARDGASSNVQATTQSAPISLLFSPQNIPDVKGAMVDYMEVYSINSTSKEYKSVVAVKNGCAQKTEYNVAFDNLDELDPVTSTWIGLVKMQAFIIFENEPLLFNYRLRFCPDRCSKPTCAAPAVSQAPSTAV
What are the official names of this protein?
EGF-like domain containing protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: RL20_YERE8
Sequence: MARVKRGVVARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNDMSYSKFINGLKKASIEIDRKILADIAVFDKVAFSALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GLYA_GEOUR
Sequence: MSILETFDPAVANAIRLETERQEYNLELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVENLAIERAKELFGAEHANVQPHSGSQANMAVYFTVLKPGDTVLGMNLAHGGHLTHGSPVNFSGKFFNIVPYGVTRENQTIDYDEVERLTLEHKPKMIVVGASAYPRIIDFAAFRKVADKVGAVVMVDMAHIAGLVAAGLHPSPVPHAEFVTTTTHKTLRGPRGGMILCREEFAKALNSNIFPGIQGGPLMHAIAAKAVAFKEALAPEFKTYQEQIVKNAKALAAGLVKQGFKLTSGGTDNHLMLVDLSETQLTGKVAEEALDKAGITVNKNGIPFDTRSPFITSGIRIGTPAATTHGLKEANMEEVAVLIADALANVENETKLAEVKGRVNAMMKRFPLYAHRLA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_CORJK
Sequence: MAKGKRTFQPNNRRRARVHGFRTRMRTRAGRAIVSARRNKGRKSLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TIG_LEPBJ
Sequence: MDYKTKKNSNATVDIKLTFEASDLEKAFDKTYAEKQKNIKIPGFRPGKAPLNMVKRHLGDTVASDAINTLIVDGMASILTKLEHPMVRFPKFEIQDYQPGKNLIATAVYETNPEITLGKYKKIKVKLPEVSVSDSDIFDEIENIRKQLARKQLKEDGQTAASGDIIDMEYTVCEKGQEPKNASNTSNDYHLGHENNLKGFDENLYGLGVGDRKEFSHTFPEDYLQNEVAGKTFEYSVTIKALYVNILPTVDDDLAAEFDGSDSLNTLKDKIRKNLKERFEEGIRNKKLEEIFKEIIDDSKYIFPDSYVKEESEHVFHNMIHEFKLPHITMEKYAKMIKKDLKEVQESFRNLAENRLKHFFTRQKIAEIENVTYTETDFDADLEKLASSYQIPLSDLKEELEKGKLMDQYRENFFAKKVDHTLFDLVEKKYTNKLSIGQVKDYLNQKEEQKV
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MDH_SYNFM
Sequence: MAKKPVRVTVTGAAGQIGYALLFRVASGQMLGPDQPIILQMLELPIDKVQAALKGVMMELEDCAFPLLADMIGTGDPKVAFKDSDYALLVGARPRGPGMERKDLLLENAKIFIEQGKAMNAVASRDIRVIVVGNPANTNAWIAMKSAPDLPKGNFTAMLRLDHNRAKSQLATRTGKPVASVEKMIVWGNHSPTMYPDIRFCTVDGQPAVKLVNDEAWYRNEYIPKVGKRGAAIIEARGLSSAASAANAAIDHMHDWALGTNGKWVTMGLPSDGSYGIPEGTMYGVPVTCTPGKYERVKGLEIDAFSREKMDFTLKELTEEQAGVKEMVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.  Catalyzes the reduction of oxaloacetate more efficiently than the oxidation of malate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: TOP6B_PYRAB
Sequence: MAEARDLFKEFKVQSVSEFFRRNAAMLGYTGKIRSLTTIIHEAVTNSLDACEEAGILPYIRVEIEELGKEHYKVIVEDNGPGIPEEYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGEIVEAWVKIDVQKNEGKIVKKLKHPNPKGWRGTRIELEVKDVKYVRSKQGVYWYLKLTAIANPHAHIELVEPDGKLVVFPRSSEDIPEPPVEMKPHPKGVMVDDVYTMAHRSKRSSVRRFLVSEFSRISDKKVDELIKYITALRLIKSETNKEVKEKLYEKLVSGDVDSVLRAFGRKWKKELEKVAKIMDKSPEKLTWHEAEEIVEAFKLMKFLAPPTHGLRPIGEENIKKGLTSILKPEFVTAVTRAPRVYAGGIPFQVEVGLAYGGQIQGSEILRYANRVPLLFDAGSCVITSAVRSIDWKRYKIDSFDSAPLVVLVNVVSVHVPYTSTGKQSIADIDEIHNEIRLALMDAARRLSFYLGGKFRRMYQVKRRKTLEKYLPEIARSLHILTGEPEEKIKEYFLKLIESKIEVEEVSEVEAEEAEA
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: PUP_CORDI
Sequence: MNQNGSQIHSDGNGHSDDTDTPGVSAGQVSVNTAGVDDLLDEIDGLLESNAEEFVRSYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: TF3A_XENBO
Sequence: MGEKALPVVYKRYICSFADCGASYNKNWKLRAHLCKHTGEKPFPCKEEGCDKGFTSLHHLTRHSITHTGEKNFKCDSDKCDLTFTTKANMKKHFNRFHNLQLCVYVCHFEGCDKAFKKHNQLKVHQFTHTQQLPYKCPHEGCDKSFSVPSCLKRHEKVHAGYPCKKDDSCLFVGKTWTLYLKHVKECHQEPVMCDECKRTFKHKDYLRNHKKTHKKERTVYCCPRDGCERSYTTEFNLQSHMQSFHEEQRPFACEHAECGKSFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLSGCAPPKSKEKSAAKATEKTGSVVKNKPSGTETKGSLVIEK
What is the function of this protein?
Involved in ribosomal large subunit biogenesis (By similarity).  Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (By similarity).  Also binds the transcribed 5S RNA's (PubMed:2331751).
What are the official names of this protein?
Transcription factor IIIA, TFIIIA.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPK1_NEIG1
Sequence: MTEQNRILCRELSLLAFNRRVLAQAEDKNVPLLERLRFLCIVSSNLDEFFEVRMAWLKRENKLHPRRRPDNGKMPSETIADVTEAARSLIRHQYDLFNNVLQPELARESIHFYRRRNWTGTQKKWIEDYFDRELLPILTPIGLDPSHPFPRPLNKSLNFAVELDGTDAFGRPSGMAIVQAPRILPRVVPLPSELCGGGHGFVFLSSILHAHVGKLFPGMNVKGCHQFRLTRDSDLTVDEEDVQNLRAAIQNELHDREYGDGVRLEVADTCPAYIRDFLLAQFRLTDAELYQVKGPVNLVRLNAVPDLVNRPDLKFPPHTPGRLKALGKNSPIFDLVRQSPILLHHPYQSFDPVVDMIREAAADPAVLAVKMTIYRTGTRSELVPALMKAALADKQVTVVVELMARFDEANNVNWAKQLEEAGAHVVYGVFGYKVHAKMALVIRREDGVLKRYAHLGTGNYHQGTSRIYTDFGLITADEQITADVNTLFMEITGLGKPGRLNKLYQSPFTLHKMVIGRIARETEHAKAGKPARITAKMNSLIEPTVIEALYRASAAGVQIDLIVRGMCTLRPGVKGLSENIRVRSIVGRQLEHARVYCFHNNGADDTFISSADWMGRNFFRRIETATPITAPELKKRVIREGLEMALADNTHAWLMQPDGGYIRAAPAEGESEADLQNDLWDLLRG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: ADT1_YEAST
Sequence: MSHTETQTQQSHFGVDFLMGGVSAAIAKTGAAPIERVKLLMQNQEEMLKQGSLDTRYKGILDCFKRTATHEGIVSFWRGNTANVLRYFPTQALNFAFKDKIKSLLSYDRERDGYAKWFAGNLFSGGAAGGLSLLFVYSLDYARTRLAADARGSKSTSQRQFNGLLDVYKKTLKTDGLLGLYRGFVPSVLGIIVYRGLYFGLYDSFKPVLLTGALEGSFVASFLLGWVITMGASTASYPLDTVRRRMMMTSGQTIKYDGALDCLRKIVQKEGAYSLFKGCGANIFRGVAAAGVISLYDQLQLIMFGKKFK
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:2167309).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
What are the official names of this protein?
ADP,ATP carrier protein 1, ADP/ATP translocase 1, Adenine nucleotide translocator 1, ANT 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QTRT2_CHICK
Sequence: MRVKLCGAAGGRLGTLAGLGRSGAAALALPGCLLYTRTGTAPHLTLDTLREVSGVPPVAQLTLPAMAELHDVLAEYKEGAAKFIGMPDTVLYCSLQDPVAPCPSGYNTNKTVSLWSSSGRMEMTASKFMDIQRAIQPDWFQCIADGDTISGEVTRKRAKKSVDRSLSFLDACLQLLEKTPELQGSVMFGTIEGGDVLEERLRSARETAKRPVGGFLLDGFQGRAMAKETKMNLISSVTAELPEDKPRIIHGVGKPDEVLECIERGVDIFESFFPFQVTERGCALVFGYDYLSDPKAEAALKQNGAQDLEKNSPEEDQEEEVVKADPEMTPFEIFLKEKRYHDDFRPLLEGCTCYCCQRHTRAYLHHLLVSSELLAGVLLMMHNFQHYFSFFSAIRDALRDDKLDQLKKLIFRQALQGPENAKIDQ
What is the function of this protein?
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane.
Protein: CSN3_MACFA
Sequence: MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).  Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3.
What is the protein family that this protein belongs to?
Belongs to the CSN3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AP3_ARATH
Sequence: MARGKIQIKRIENQTNRQVTYSKRRNGLFKKAHELTVLCDARVSIIMFSSSNKLHEYISPNTTTKEIVDLYQTISDVDVWATQYERMQETKRKLLETNRNLRTQIKQRLGECLDELDIQELRRLEDEMENTFKLVRERKFKSLGNQIETTKKKNKSQQDIQKNLIHELELRAEDPHYGLVDNGGDYDSVLGYQIEGSRAYALRFHQNHHHYYPNHGLHAPSASDIITFHLLE
What is the function of this protein?
Probable transcription factor involved in the genetic control of flower development.  Is required for normal development of petals and stamens in the wild-type flower.  Forms a heterodimer with PISTILLATA that is required for autoregulation of both AP3 and PI genes.  AP3/PI heterodimer interacts with APETALA1 or SEPALLATA3 to form a ternary complex that could be responsible for the regulation of the genes involved in the flower development.  AP3/PI heterodimer activates the expression of NAP.  AP3/PI prevents GATA22/GNL and GATA21/GNC expression (PubMed:18417639).
What are the official names of this protein?
Floral homeotic protein APETALA 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAMH1_BOVIN
Sequence: MQSADSQNTPKRPRRDGSPRTPPDSPLADAETSPSHDLDPDYRTWGPEQVWSFLRRCGFSDSELLKRCREKRMSGSLLPFPEDLGISSHGKKMKLLNCIQDTMKVINDPIHGHIEFHPLLMRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGRLVRELSEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEIKWTHEQGSVMMFEHLINSNGLQDVMKYYGLIPEEDILFIKEQITGPPESPIKDASKWLYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNSFDYKRFLKFARVCEVDNMKHICTREKEVGNLYDMFHTRNCLHRRAYQHKVGNIIDTMITDAFLKADDHIEITGSAGRKYHISTAIDDMEAFTKLTDNIFLEILYSTDPNLNDARMILKKIESRNLYKFVGETQPMIQRIKKENYEHLPNEVASAKPSDVELEAELKAEDLIVDVINMDYGMEDKNPIDHVRFYCKSDLSKAVMITRNQVSQFLPETFAEQLIRVYCKKTDEKTLFAARQHFVHWCLINDFTKPQIKKLPLRKLKKELTTATG
What is the function of this protein?
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity).  Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells.  Likewise, suppresses LINE-1 retrotransposon activity (By similarity).  In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools.  Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication.  Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation.  Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity).  Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity).
What are the official names of this protein?
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase.
What is the protein family that this protein belongs to?
Belongs to the SAMHD1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to sites of DNA double-strand breaks in response to DNA damage.