PharMolix/UniProtQA huggingface dataset:
Protein: VL1_HPV15
Sequence: MTLWLPTTGKVYLPPTPPVARVQSTDEYVERTNVFYHAMSDRLLTVGHPYFDVRSVNGGSIEVPKVSGNQYRAFRVTFPDPNRFALADMSVYNPEKERLVWACVGLEIGRGQPLGVGTSGHPLFNKVKDTENNSNYQGNSTDDRQNTSFDPKQVQMFVVGCVPCLGEHWDRALVCESERNNQAGKCPPLELKNTVIEDGDMFDIGFGNINNKALSVTKSDVSLDIVNETCKYPDFLTMANDVYGDACFFFARREQCYARHYFVRGGAVGDALPDAAVNQDHNFYLPAQSTQQQNNLANSTYFPTVSGSLVTSDAQLFNRPFWLRRAQGHNNGILWGNQMFITVADNTRNTNFTISVTSDGNAINEYNSQNIREFLRHVEEYQLSIILQLCKIPLKAEVLTQINAMNSGILEDWQLGFVPTPDNAVQDIYRYIDSKATKCPDAVQPKDKEDPFGKYTFWNVDLTEKLSLDLDQYPLGRKFIFQAGLQRRPRTIKSSVKVSKGTKRKRT
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: S52A2_HUMAN
Sequence: MAAPTPARPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLAPGKDEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFLSHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPINGTPGPPLDFLERFPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPSQAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYHVFHSRKDCADPCDS
What is the function of this protein?
(Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
What are the official names of this protein?
Solute carrier family 52, riboflavin transporter, member 2, Porcine endogenous retrovirus A receptor 1, PERV-A receptor 1, Protein GPR172A, Riboflavin transporter 3, hRFT3.
What is the protein family that this protein belongs to?
Belongs to the riboflavin transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSRP_CITK8
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAYLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RS6_ACTP2
Sequence: MRHYEIVFMVHPDQSEQVPAMIERYTASVKEAGGQVHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQRVIDELETNFRYNDAVLRNLIVHTKAAVTEASPMVKAKESKVAEAVAEVESEEAGE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: THIC_RHOBA
Sequence: MTQLLSARAGEITPEMEYVAKREDLPVELIRDEVASGRMVIPANKVHAAGALEPMAIGIAAKCKINANIGNSAVTSNVGEELEKLHTAVHFGADTVMDLSTGKDIDNIRRQIIDKSPVPIGTVPIYQMLEELGGNIEDMNAQHFLDMVEHQAKQGVDYMTIHCGVKLEHLHLTVNRVTGIVSRGGSLIAKWMMAHNKQNPLLEAFDDLCDIMREYDVTWSLGDGLRPGSIADASDDAQFAELDVLGECTKRGWEKGTQVMVEGPGHIPLDQIQMNIERQIEVCHGAPFYVLGPLVTDIAPGYDHITSCIGAANAGMHGAAMLCYVTPKEHLGLPNEEDVKQGVIAYKIAAHTADVARKRKGAQDRDDALSKARFAFDWKEQFRLSLDPETAQRYHDETLPQDTFKSAHFCSMCGPKYCSMKITEDIRQMAKEKKLVELPTT
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: BIOB_XANOM
Sequence: MSVVVRHDWDHKELQALFDLPFPELLHRAASVHRAHFDPAEVQVSTLLSVKTGGCPEDCAYCPQAQRYDTGVTAQKLLETEEVVAKARQAKAAGASRFCMGAAWRSPKERDIPKVAAMIREVKAMGLETCATLGMLDAGQARALKDAGLDYYNHNLDTAPDYYDTIIHTRQYQDRLNTLEHVRDVGLKTCCGGIVGMGETRDHRIGLLLALATLPAHPDSVPINQLVQVPGTPLHGTQQLDPFEFVRMIAVARIAMPKSMVRLSAGREAMSDELQALCFLAGANSIFYGEKLLTTGNPDTERDQTLFQRLGLRPMQITVDAAEHDHPATVHAEITRSAACEHTA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: DDRA_CAEEL
Sequence: MQIALVLLAIYGTTTTNTLRIDQCGENALGMQNGDIADSQITASSSFDKQSVGPQNARLHSELASGAWCPKPQINSKSYEFLQVTLNDTFLITSVETQGRYGNGTGREFASHYMIDYLRPGSQWIRYKNRTGHVYMDGNFDTTTPVIRVLDPPIVASRIRFVPSSKNTRTVCMRAEIHGCKHEGVTYYSTVPDGSRLDTLDFKDSMFEDSQIYTESGIKRGLGLLTDGFVAQASPFEKNQMNNSWIGWNRDTTDGRITILFEFEEVHNFTDVVLATFGNRIDGIDVIFSQDGKTFPLFSQISSSERQSLNNTSRRYDFRVPLHNRAGRKVRISIKFSSDWMFLTEVHFTSAANLTLLSEKIPPPSSAATQQLLVVCGIIFLTIFACVAYCVSVCLKRRQKNKSVDSNVKKDLIITHMGNKPTCHVFPSNGKLSNGHYEVANDILYARSQKSTLLSVSSKSTFSCRAIPPTWTDFNFPPPPEGREEHTYSQPVSPENSSNGSYKSVRKIQALKKYPSSALLIGKAIGEGKFTMIKECIIFGGLKCAHKSTKEEDCVHGTRALGDEIACLLQCGRHPRIVELFGVDESYNLLLEHVEYGCIRNFWMASEAPLDTEFLVRICKDIYSAMAYLESIRIVHGHFTPNNILMDGEFHAKVCSPRGPSHHAQLRYSAPESIVNNEFTHKSDAWAVATTVYEMAYQCRQRPYEELTNEQIVDNACALLDHQPNAVVPLMPTVFNYEILQLLTRCFRVDQLERPTFERLVKPFQD
What is the function of this protein?
Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development (PubMed:23147028).  May play a role in axon regeneration following injury in D-type motor neurons (PubMed:27984580).
What are the official names of this protein?
Discoidin domain-containing receptor A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon.
Protein: SCTD_DICDI
Sequence: MKIYYLFFVLIYLIYFINLVYCEKNDTSIILDDILDIQHNRKLFPKITHQDIENIRQIRRMNLHSIVKSMSTLNVQDLGLGIFAGLEKSVNPNPNECIDSLRTSIDNTNQVFYDISNFFGITIQEFLTLIQIFPTIIKDDIRLYDACGANVIVMKIGKFAHIIRTEGLQSFANYAKNALYSNPFYLIPVTRGLLESLVTKNYQMLGVHIGEYLGILFNSDDD
What are the official names of this protein?
Secreted protein D.
What is the protein family that this protein belongs to?
Belongs to the Sct family.
What are the subcellular locations of this protein?
Secreted.
Protein: NS1_I78A1
Sequence: MDSNTITSFQVDCYLWHIRKLLSMRDMCDAPFDDRLRRDQKALKGRGSTLGLDLRVATMEGKKIVEDILKSETDENLKIAIASSPAPRYITDMSIEEISREWYMLMPRQKITGGLMVKMDQAIMDKRITLKANFSVLFDQLETLVSLRAFTDDGAIVAEISPIPSMPGHSTEDVKNAIGILIGGLEWNDNSIRASENIQRFAWGIRDENGGPPLPPKQKRYMARRVESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: RS7_PHEZH
Sequence: MSRRRRADKREVLPDPKFGDLVVTKFMNYVMYEGKKAVAENIVYGAFDILEARRKDMGPLETFHAALDNVAPAIEVRSRRVGGATYQVPVEVRPERRRALAIRWLVNAARSRGENTMTEKLAGELLDASSNRGSAVKKREDTHKMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MNMG_LACAC
Sequence: MIKTYDSNEYDVIVVGAGHAGCEAALASAHMGQKTLLVTIGLDMVAFMPCNPSVGGPAKGTVVREIDALGGQMGKNIDATYIQMRMLNTGKGPAVRALRAQADKWQYHEYMKDTIENTPNLTLRQAIVDELVVEDGVCKGVITNTGAKYHAKSVVLTTGTAARGKIIIGELMYSSGPNNTTPSIKLSENLEKLGFKLRRFKTGTPPRVNGNTIDYSKTEEEPGDKVPRHFSYESKDENYLQNQISCWMTYTNPVTHEVIRDNLDRAPMFTGVIKGVGPRYCPSIEDKVVRFADKDRHQIFLEPEGKTTKEVYVGDFSTSMPEEVQLKMVHSVAGLEHAEMMRPGYAIEYDVVEPWQLKHTLETKNVKHLFTAGQMNGTSGYEEAAGQGLIAGINAALSAQGKSGFTLGRNDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLILRHDNADLRLTEYGHKLGLISDDRYQAFEEKKQAIKDTQARLHEITVHVTDEVQDFLKSIGQEPMKAGVKADVFLRRPHVTINDIERLTGQKIDGDRYVKEQVEIGIKYAGYIKKEETRIARLKRQEAKKIPADIDYNMIEGLATEARQKFEKIRPETLAQAERISGVNPADLAILSVYIQNGRYSRVNK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMH2_YEAST
Sequence: MSQTREDSVYLAKLAEQAERYEEMVENMKAVASSGQELSVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKEKSEHQVELIRSYRSKIETELTKISDDILSVLDSHLIPSATTGESKVFYYKMKGDYHRYLAEFSSGDAREKATNSSLEAYKTASEIATTELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDISESGQEDQQQQQQQQQQQQQQQQQAPAEQTQGEPTK
What are the official names of this protein?
Protein BMH2.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HAS1_KLULA
Sequence: MAGNKRVRDAESEQDHAETETVVKDTATTGEVEGSFSDLKLSDGTMKAIGKMGFTQMTAVQTRTIPPLLAGKDVLGAAKTGSGKTLAFLIPAIEMLHSLKFKPRNGTGVIVITPTRELALQIFGVARELMEFHSQTFGIVIGGANRRQEADKLMKGVNILIATPGRLLDHLQNTKGFIFKNLKALVIDEADRILEIGFEDEMRQIIKILPNEDRQSMLFSATQTTKVEDLARISLRPGPLFINVDSEKDTSTADGLEQGYVVCESDKRFLLLFSFLKRNQKKKVIVFLSSCNSVKYYAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAERGILVCTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTKGKGKSLMFLTPTELGFLRYLKAAKVPLNEYEFPTNKIANVQAQLEKLIKSNYYLHQIAKDGYRSYLQAYASHSLKTVYQIDKLDLAKVAKSYGFPVPPKVNITIGASGKTPATKKRRTKD
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase HAS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIRM1_POEMA
Sequence: MFSLKLFVVFLAVCICVSQAVSYTDCTESGQNYCLCVGGNLCGGGKHCEMDGSGNKCVDGEGTPKPKSQTEGDFEEIPDEDILN
What is the function of this protein?
Hirudin is a potent thrombin-specific protease inhibitor.  It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.
What are the official names of this protein?
Hirudin-HM1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I14 (hirudin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GVPA1_STRCO
Sequence: MTVVPAQQTGGGGSSGLYDVLELVLDRGLVIDAFVRVSLVGIEILKIDVRVVVASVDTYLRFAEACNRLDLEAGPRKDPGLPDLVGEMTESGARGKSKGALSGAAETISDAFKQARDDGGSERETSSRPRARKAAPSRRKEEQE
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure (By similarity).
What are the official names of this protein?
Probable gas vesicle structural protein 1, GVP.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: MSD7_AMABI
Sequence: MSDINTARLPLSSPMLLPCVGDDILMV
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:18025465).
What are the official names of this protein?
MSDIN-like toxin proprotein 7.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: TRPB_ECOSE
Sequence: MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETNVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPDKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CH60_GEOSE
Sequence: MAKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGIRKGIEKAVAVAVEELKAISKPIQGKESIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKGFATELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSSIQEILPILEQVVQQGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRELKSATIASLGRASKVVVTKENTTIVEGAGDSKRIKARINQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTALMNVYSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQTAGLEGSIIVERLKTEKPGIGFNAATGEWVDMIEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGNPGMPDMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFHA1_MOUSE
Sequence: MAGQDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDPLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKNDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPSPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ
What is the function of this protein?
Probable GTP-binding protein (By similarity).  Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:20616063, PubMed:26599367).  Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1.  By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity).  Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367).  Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype.  It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway.  Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (By similarity).
What are the official names of this protein?
Malignant fibrous histiocytoma-amplified sequence 1 homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LON_MESH2
Sequence: MPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRNDFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSEWQTVILDFIVTEKVQLVELINDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPSLTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIEELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALPWKKVKKDILDIKNVREKLEEAHYGLDEIKKRIIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISLGGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELEYDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGVRGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGRGDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHNIAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_BACC4
Sequence: MRILGLDVGTKTVGVAISDEMGWTAQGLETIKINEERGHFGFDRISELVKQYNVDKIVVGLPKNMNGTIGPRGEACQQFAENLRELLQLDVVMWDERLSTMAAERLLISADVSRKKRKQVIDKMAAVVILQGFLDRK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_ACIC1
Sequence: MSDAGHVDAVCKPLGAADIRELARSAGVRPRKTFGQHFVVDPGVLRKIARYAELSSEDIALEIGPGFGSLTLVLLPLVRRLLAVEIDRVLAAVLPETIRRRCPAFADRLVVVHGDVLRLTTLPDDPTVLVANLPYNVAVPAVLRVFERFSTVTRTVIMVQREVAERLCADPGSPAYGAPSIKLRWYGRARIVGSVSADVFWPRPQVESAVVRIDRQPPPVPGVDRAAVFAVIDAAFAQRRKMLRRALSGWAGSAQAAEERILAAGLRPTDRGEALTLADFIRLAQAPPTR
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_CAMJR
Sequence: MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLNLPILGICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIKEQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIGNTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPGLELLRKADVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLENISRRIINEVEGINRVVYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RIMP_THEMA
Sequence: MFEEMILEKVRKEAERIAEEQGLEIFDVQYRRESRGWVLRIIIDNPVGYVSVRDCELFSREMERFLDREDFIEHSYTLEVSSPGLDRPLRGPRDYVRFTGKLAKIVTKDGKTFIGRIESFVDGTITISDEKRKYEINIDDVKRANLEVEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y438_STAEQ
Sequence: MKRYLITGGTGMVGSHLVNEIKQTDAHITILTRQDKTSNHPKITYINWSKEGWQHQVPDIDIVINLAGATLNKRWTSSHKQAMMLSRIQSTQTLFELFETREHKPEVLFNASAMGYYPPDLFTSYTELYRTLPFDFLSEIVYQWERFANKFKQFGTRVVLGRFGLILSDDGGALEMMELPYRLYVGGKLGSGRQWYSWIHIDDLIRGILFTINHDNAEGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPKLILRAVLGQMSTVILDTQKVLPNKLHALGFEFKYNNLRNALDDLIKA
What are the official names of this protein?
Epimerase family protein SERP0438.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Protein: RS2_STAAR
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAYNFLKQVSEDGGQVLFVGTKKQAQESVKSEAERAGQFYINQRWLGGLLTNYKTISKRIKRISEIEKMEEDGLFEVLPKKEVVELKKEYDRLIKFLGGIRDMKSMPQALFVVDPRKERNAIAEARKLNIPIVGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAILEGQQGVSNEEVAAEQNIDLDEKEKSEETEATEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.