PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_SHEFN
Sequence: MVYSYSEKKRIRKDFGKRPKVLDIPYLLSIQLDSFKKFTDHDPTGERGLEAAFRSVFPIKSFSGYSELQYVSYKLGEPVFDVKECQIRGVTYSAPLRVKLRMVLFDREAAAGTVKDIKEQEVYMGDIPMMTNNGTFVINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDALFVRIDRRRKLPATIILRALEYSTQDILDLFFERIEFKIKKDSLVMALVPDRLRGETAGYDIKDAEGALLVEAGRRITARHIKQLEKTNTTELEVPVDYIVGKYAAQDYIDEDTGEVLVTANSEITLEDLAKLSLAGIKNIDTLFINDLDHGAYIADTLRIDSTTNRLEALVEIYRMMRPGEPPTKDAAEGLFQNLFFSEERYDLSKVGRMKFNRRLEIAEDEGNGVLSKEDIVSVMKKIIEIRNGYDEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVRERLSLGDLNELMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHPTHYGRLCPIETPEGPNIGLINSLASFARTNSYGFLETPYRKVVDGVITDDVEYLSAIEEGRYVIAQANIEVDADGRMAEEQIACRHKGESTFMRAADVQYMDVSPQQIISVAASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGIERTLAVDSGVVVAAKRGGVVDYVDASRIVVKVNEDELHAGEAGIDIYNLTKYTRSNQNTCINQRPCCSVGEPVVRGDVLADGPSTDLGDLALGQNMRIAFMPWNGYNFEDSILISERVAQEDRFTTIHIQELSCIARDTKLGSEEITADIPNVGESALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVKGTIIDVQVFTRDGVEKDKRALEIEDMHVRQARKDLGEEFKILEEGVLGRARNLLLSVGYSEAKLAEIPRKDVLIQVIDDETKQTELEQLAEQHEELKADFDKTFEIKRRKITQGDDLAPGVLKIVKVYLAVKRTIQPGDKMAGRHGNKGVISKICPVEDMPYDEEGNPVDIVLNPLGVPSRMNIGQVLEVHMGAAAKGIGNKITAMLEEQREIAELRGYIKQVYELGDDVLQRVDIDSFTDDEVVRLATNLKGGIPIATPAFDGAKEKEIKQMLALAGLPESGQLTLCDGRTGNEFERKVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTQMYKNIVDGNHQMQPGMPESFNVLLKEIRSLGINIELDQE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MUTL_SALEP
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEEIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRALLQTPATSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ALBA_METTP
Sequence: MAEDDVVFVGNKPVMNYVLAVVTQFNSGAKEVRIMARGRAISRAVDVAEVSRSRFLGDVVVKDIKISTETLNTDRGETNVSAIEIVLGK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: PDXJ_NITWN
Sequence: MSSSQSLRLGVNVDHVATIRNARGGDRPDVVRIALAAIAAGADGITAHLREDRRHIRDSDMARLKAEIEKPLNFEMAATAEMQGIALATQPHAVCLVPERREELTTEGGLDAAGQYNALAPFIAKLNDAGIRVSLFIAADPRQIEAAAKLRAPVIEIHTGGWCDAVVEGDSGKADAEWRRIVEGAALARSVGLEVHAGHGLDYATAETIAALPEITELNIGYFMMGEALLVGIAETVRTMRAAMDRGRATLKTRTA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_PORGI
Sequence: MTPTTNNKRINFASIKNPLFYPDFLEVQLKSFHDFLQLDTPPERRKKEGLYKVFAENFPITDTRNNFVLEFLDYYIDPPKYSIEECLSRGLTYSVPLKAKLKLYCTDPDHEDFATVIQDVFLGPIPYMTSSGTFVINGAERVIVSQLHRSPGVFFGQSLHTNGTKLYSARIIPFKGSWIEFATDINNVMYAYIDRKKKLPVTTLLRAIGFEADKDILDIFNLAEEVKVTKANLKKCIGRKLAARVINTYIDDLSDEDTGEVVSMERITVVVDREVELTEDNIEAILNSNTQTILLHRNDSNTSDYSIIFNTLQKDPCNSEKEALYYVYRQLRNAEPADDASAREVITNLFFSDKRYDLGDVGRYRINKKLNLNIDPDIKVLTNEDIIEIIKYLIELVNSKASVDDIDHLSNRRVRTVGEQLYNQFGIGLARMARTVRDRMNVRDNEVFTPIDLVNAKTISSVVNSFFGTNALSQFMDQTNPLAEITHKRRLSALGPGGLSRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLCVYAKISDLGFITTPYREVKNGKVDFSDNGLKYYTAEEEEEKTVAQGNAPLDENGRFVRERVKARYESDFPLVTPDEVDLMDVSPTQIASIAAALIPFLEHDDANRALMGSNMMRQAVPLLRPESPIVGTGIEGKLVKDSRTQIVAERGGEVVFVDASCIKIRYDRTADEEFVSFDDAIVTYYLPKYRKTNQSTTIDLHPICSKGDRVEAGQILTEGYSTQGGELALGRNVQVAYMPWKGYNYEDAIVLNERMVREDFFTSVHVDEYILEVRETKRGLEELTSDIPNVSEDATRDLDENGIVRIGAHIEPGDILIGKITPKGESDPTPEEKLLRAIFGDKAGDVKDASLKATPSLRGVVIDTKLFSKAAKKKSRTSTKEAVSKLDETYAKRQQQLHERLIDKLTELTKGKTCCGVKDYLNVELIKAGSKFAKKDLEALDFNVIQLSDWTNDAHTNELIKAVAVNYLKHSKEIEAELRRRKLDETIGDELPAGIVQMAKVYIAKKRKIQVGDKMAGRHGNKGIVSKIVRQEDMPFLADGTPVDICLNPLGVPSRMNLGQIFEAVLAWAGRKMNVKFATPIFDGASLNDMNEWTDKAGLPRDGKTYLYDGGTGERFDQPATVGVTYFLKLGHMVDDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAFGASHILQEILTVKSDDVVGRSKAYEAIVKGDPMPTPGIPESLNVLLHELKGLGLSFSLD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MPTA_METST
Sequence: MTVSEFPDTQDKQPSIPISLTRVGVTGVKKLIKIKREDKRPIILIPTFDAFVDLPSTQKGVHMSRNPEAISEIVDEAANQSEIHLENICANLVKRLLEKHEYALHAETEARGEYIINKLSPVSKRKTQETTHIIARAIAMKDDEGNISVRKMIGAEVIGMTVCPCAQESVEKDSKDKLLEFLDEETTQKVLDVVTFASHNQRGVGTILLEVPEKQDVNVDDLIKIIQDAMSSPVCEILKRPDENRIVTNAHQNPVFVEDCVRNMVIGLLEKYPNLPDDSVVTIKQVNQESIHQHNAYAEKVASFGKLREENKE
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: WDFY2_HUMAN
Sequence: MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS
What is the function of this protein?
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651).  Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859).  Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity).  Participates in transferrin receptor endocytosis (PubMed:16873553).
What are the official names of this protein?
WD repeat and FYVE domain-containing protein 2, Propeller-FYVE protein, Prof, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22.
What are the subcellular locations of this protein?
Endosome. Early endosome. Cytoplasm. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity).
Protein: SUCC_SALG2
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVKSKEEIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIGKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDNVKAVLVNIFGGIVRCDLIADGIIGAVEEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKSLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: HPPD_PSEAE
Sequence: MNAVAKIEQHNPIGTDGFEFVEFTAPDAKGIEQLRQLFNMMGFTETAKHRSKEVFLFQQNDINIVLNGSPTGHVHEFALKHGPSACAMAFRVKNASQAAAYAESQGAKLVGSHANFGELNIPSLEGIGGSLLYLVDRYGDRSIYDVDFEFIEGRSANDNSVGLTYIDHLTHNVKRGQMDVWSGFYERIANFREIRYFDIEGKLTGLFSRAMTAPCGKIRIPINESADDTSQIEEFIREYHGEGIQHIALTTDDIYATVRKLRDNGVKFMSTPDTYYEKVDTRVAGHGEPLEQLRELNLLIDGAPGDDGILLQIFTDTVIGPIFFEIIQRKGNQGFGEGNFKALFESIEEDQIRRGVI
What are the official names of this protein?
4-hydroxyphenylpyruvate dioxygenase, 4HPPD, HPD, HPPDase.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: ASSY_SOLUE
Sequence: MGNILQNLPAGEKVGLAFSGGLDTSAAIHWMRAKGAIPYSYTANLGQPDEPDYDEIPRRALLYGAEKARLIDCRKQLVAEGIAALQSGAFHISTAGVHYFNTTPIGRAVTGTMLVIAMKEDDVHIWGDGSTFKGNDIERFYRYGLLANPALRIYKPWLDQTFIDELGGRKEMSEYMISHGLTYKMSVEKAYSTDSNIWGATHEAKDLEHLDKGVKIVEPIMGVASWREDVAIKPETVTIRFEEGQPVALNHVTYDDPVQLVLEANAIGGRHGLGVSDQIENRIIEAKSRGIYEAPGLALLFIAYERLVSGIHNEDTIEQYRINGLRLGRLLYQGRWFDSQSMMLRETAQRWVARAITGEVTVELRRGNDYSILDTTSPNLTYKPERLTMEKGESTFSPQDRIGQLTMRHLDITDTRDKLLLYIKTGLLGPSSGNSTTLLPEPADSGTEKPPSR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAJ2_PROM1
Sequence: MFKIFRTKWFRSAPVLATLWLSSTAVILIGVNSYFPDYLFMPMS
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX 2.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: INS_MYOCO
Sequence: YVSQRLCGSQLVDTLYSVCRHRGFYRPNDGIVDQCCTNICSRNQLMSYCND
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UMEC_ARMRU
Sequence: EDYDVGGDMEWKRPSDPKFYITWATGKTFRVGDELEFDFAAGMHDVAVVTKDAFDNCKKENPISHMTTPPVKIMLNTTGPQYYICTVGDHCRVGQKLSINVVGAGGAGGGATPGA
What is the function of this protein?
Probable electron transfer copper protein that serves as a direct electron donor (PubMed:5089608, PubMed:11945593).  Does not show any activity towards ascorbic acid, p-phenylenediamine and several common 'classical' substrates for copper proteins (PubMed:5089608).
What are the official names of this protein?
Umecyanin, UMC.
Protein: GRI_ARATH
Sequence: MVIKIPNTFIKATSLLSLILYFLIIATSKSNSVLADEVVDQEDDPEYYILDETPSILSNVTISSKTRLLVSHYKKIKKGMRCHVESYNICNGVKANKGTSLLHCCKKHCRNVLGDRNNCGRCGHKCGFGQRCCGGVCTYVNFNPNHCGKCTRKCASGVKCEYGYCGYA
What is the function of this protein?
Involved in the regulation of cell death induced by extracellular reactive oxygen species (PubMed:19279211, PubMed:25398910).  Only the processed peptide, and not the full length GRI can bind in vivo to the extracellular domain of the receptor PRK5 (PubMed:25398910).  The GRIp-induced cell death is superoxide and salicylic acid dependent (PubMed:19279211).
What are the official names of this protein?
Protein GRIM REAPER, Stigma-specific STIG1-like protein GRI.
What is the protein family that this protein belongs to?
Belongs to the STIG1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: RPOA_PROMS
Sequence: MLQYQIDRIDHQIADDRSQTGTFLIGPLERGQATTLGNSLRRVLMGGLEGSAVTAVRIAGINHEYATIPGVREDVLDILLNCKQLSINSSNPELEIGRLVASGPMEVKANDIQFSSQVEIVDGEKPIATIQEGHNLELEIHVERGVGYRPVDRKSEETTAIDLLQIDAVFMPVKRVNFTIDETAVAEGATGRERLKMEVVTDGSTSPDDAIAEAANQLIELFQPLATVTMVEEIPEEPEPSPEAQIPLEELNLSVRAYNCLKRAQVNSVSDLMGFSYEDLLEIKNFGSKSADEVIEALERIGISIPQSRTSV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RECO_RHOBA
Sequence: MAIVLRTVDFSETSLIVTLLTKDLGRISALAKGARRLKGPFEGSLDLLSVCAITLIDKPGDTLDLLTESKLRRRFRGAQRSLERLHAGYYIAEMLRLLVDDDDPHRELFDMTLSAMGMIDGEGHVAKTLLAFDAQCLRLLGHSPATQRCTVCGRDAERSRRRASFSLVGGGVVCENCRPSQSHLMTASWDALDALRELASEPELPPSTIDADTDNPSQPPSTAFPIGRLFPAMTPAIYRDLRGLLNRTLESLVGQTPRMQPFLPDKLDSL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ZDHC6_ARATH
Sequence: MKRKGVGFSLPVTVVMLVIGFIYFASVFTFIDRWFSLTSSPGIANAAAFTALALMCIYNYSIAVFRDPGRVPLNYMPDVEDPESPVHEIKRKGGDLRYCQKCSHFKPPRAHHCRVCKRCVLRMDHHCIWINNCVGHTNYKVFFVFVVYAVTACVYSLVLLVGSLTVEPQDEEEEMGSYLRTIYVISAFLLIPLSIALGVLLGWHIYLILQNKTTIEYHEGVRAMWLAEKGGQVYKHPYDIGAYENLTLILGPNILSWLCPTSRHIGSGVRFRTAFDSIPDSSETKH
What is the function of this protein?
Palmitoyl acyltransferase.
What are the official names of this protein?
Probable protein S-acyltransferase 16, Probable palmitoyltransferase At3g09320, Zinc finger DHHC domain-containing protein At3g09320.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RS17_METPP
Sequence: MTTQETVKNTRTLVGRVVSDQRSKTITVLVERRVKHELYGKIVARSRKYHAHDENNEYKLGDLVEIAEGRPISKTKAWVVTRLVEKARVV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: YCIC_SHIBS
Sequence: MSITAQSVYRDTGNFFRNQFMTILLVSLLCAFITVVLGHVFSPSDAQLAQLNDGVPVSGSSGLFDLVQNMSPEQQQILLQASAASTFSELIGNAILAGGVILIIQLVSAGQRVSALRAIGASAPILPKLFILIFLTTLLVQIGIMLVVVPGIIMAILLALAPVMLVQDKMGIFASMRSSMRLTWANMRLVAPAVLSWLLAKTLLLLFASSFAALTPEIGAVLANTLSNLISAILLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMA_ACIF5
Sequence: MMQEGGLPRAKKRFGQNFLVQPQIVERIVAAIRPASGDHLVEIGPGPGALTKSLLRLLPQFTVVELDRDMIAGLRALAPPEQLRVLQADALEVDFAALAGAGNALRIVGNLPYNVATPLIFHILEHAEQVRDMHFMLQKEVVDRVVAMPGSKAYGRLSVMIQAYCAVESLFTVAPGNFFPVPKVDSAFMRLIPHRPGLLPPHLQAPFARIVATSFAQRRKTLANNLRGILSADDLRGLQIDPGSRAETLDQAAFFRLAEATVEQGNRS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TERS_BPT5
Sequence: MANDVLVPDLMSPEGMDVIEAYLQCGSDVPSAARSLGMSEIAFRDIMNRSEVKNYLNDIFMESGFRNRDRLFGVLDEVIKRKLEELEETGMGSDQDIMDILWKAHKMKMEEMKMMVELEKVKAAARTPANQTNIQNNIIAGAGDQNYMDLITSLATGGKK
What is the function of this protein?
The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit.  The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities.  Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine.  The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer at the long non-permuted direct terminal repeats.  Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
What are the official names of this protein?
Probable terminase, small subunit.
Protein: RS6_STAA3
Sequence: MRTYEVMYIVRPNIEEDAKKALVERFNGILATEGAEVLEAKDWGKRRLAYEINDFKDGFYNIVRVKSDNNKATDEFQRLAKISDDIIRYMVIREDEDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RIR1_VZVO
Sequence: MEFKRIFNTVHDIINRLCQHGYKEYIIPPESTTPVELMEYISTIVSKLKAVTRQDERVYRCCGELIHCRINLRSVSMETWLTSPILCLTPRVRQAIEGRRDEIRRAILEPFLKDQYPALATLGLQSALKYEDFYLTKLEEGKLESLCQFFLRLAATVTTEIVNLPKIATLIPGINDGYTWTDVCRVFFTALACQKIVPATPVMMFLGRETGATASCYLMDPESITVGRAVRAITGDVGTVLQSRGGVGISLQSLNLIPTENQTKGLLAVLKLLDCMVMAINSDCERPTGVCVYIEPWHVDLQTVLATRGMLVRDEIFRCDNIFCCLWTPDLFFERYLSYLKGASNVQWTLFDNRADILRTLHGEAFTSTYLRLEREGLGVSSVPIQDIAFTIIRSAAVTGSPFLMFKDACNRNYHMNTQGNAITGSNLCTEIVQKADAHQHGVCNLASINLTTCLSKGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKGVKNNRSLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAPFKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQFLALMPTVSSAQVTECSEGFSPIYNNMFSKVTTSGELLRPNLDLMDELRDMYSCEEKRLEVINILEKNQWSVIRSFGCLSNSHPLLKYKTAFEYEQEDLVDMCAERAPFIDQSQSMTLFIEERPDGTIPASKIMNLLIRAYKAGLKTGMYYCKIRKATNSGLFAGGELTCTSCAL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, R1, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: GREM1_MACMU
Sequence: MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
What is the function of this protein?
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop.  Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity).  Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity).  Acts as inhibitor of monocyte chemotaxis.  Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
What are the official names of this protein?
Gremlin-1.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGC_NEIM0
Sequence: MSKKIKVGIVGATGYTGVELLRLLAAHPDVEVAAVTSRSEAGTAVADYFPSLRGVYGLAFQTPDEAGLEQCDIVFFATPNGIAMKDAPRLIEQGVRVIDLSADFRIRDIPTWEHWYGMTHAAPDLVSQAVYGLSELNREAVAQARLVANPGCYPTCVSLPLVPLLRQCRLKPGMPLIADCKSGVSGAGRKGNVGSLLCEAGDNFKAYGIAGHRHLPEIRQTIAGLQDGIAEGFVFTPHLAPMIRGMHATVYLHLSDGSNPETVLRDYYRDSLFVDILPAGSTPETRSVRGANLCRISIQQAAQSDVWVVLSVIDNLVKGAAGQAVQNMNIMFGLKETHGLDAIPLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST2A1_MOUSE
Sequence: MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAGFPPGIFPWE
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:12639899).  Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups.  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Plays an important role in maintening steroid and lipid homeostasis.  Plays a key role in bile acid metabolism (By similarity).  In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
What are the official names of this protein?
Sulfotransferase 2A1, ST2A1, Bile salt sulfotransferase 1, Hydroxysteroid sulfotransferase, ST.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.