PharMolix/UniProtQA huggingface dataset:
Protein: FMT_GLAP5
Sequence: MKKLNIIFAGTPDFAATHLQALLNSEHNVIAVYTQPDKPAGRGKKLQASPVKQLAEVHHIPVYQPKSLRKEEAQAELQALNADVMVVVAYGLILPEAVLKAPKYGCLNVHGSLLPRWRGAAPIQRSIWAGDTETGVTIMQMDIGLDTGDMLHKVTTPILATETSASLYAKLAELAPPALLEVLNGLTSGQFKPEKQQDEQANYAEKLTKEEAKLDWNMTACQLERNIRAFNPAPMAYLTLMVNEVEERIKVYQAEVLPHQEKTVGTVLAVDKNGIQIATQQGVLNITQLQPAGKKPMSVQDFLNGRGDWFKVGSVL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MDTD_SALEP
Sequence: MTELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPASGWLADKIGVRNIFFAAIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEYASWHWIFLINIPVGIVGAMATFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILLYLFHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQIVNRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVLLLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLSMSIGVTIAGMLLGMFGQQHIGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TDXH_STAMF
Sequence: MPGTIPLIGEKFPEMEVVTQHGKIKLPDYFKGKYWVLFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELIGLSVDSNFSHIKWIEWIKEKLGVEIPFPIMADPRGTVASKLGMLHAASSTHTVRAVFVIDPNGIIRAIIYYPLDNGRNIDEILRLVKAIQITDKYGRATPANWPNNELIGDSVIVPPAGTVKEAEERLKKYKCFDWWFCYEEGVVPKEEVEEVRKWLERAAKLQK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Peroxiredoxin, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGMR1_RAT
Sequence: MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
What is the function of this protein?
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane.  Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling.  Also regulates ion channels like the potassium channel and could modulate neurotransmitter release.  Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum.  Plays a role in several other cell functions including proliferation, survival and death.  Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.  Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria.  Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
What are the official names of this protein?
Sigma non-opioid intracellular receptor 1, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R.
What is the protein family that this protein belongs to?
Belongs to the ERG2 family.
What are the subcellular locations of this protein?
Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (By similarity). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (PubMed:15466698). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity).
Protein: JMT1_THECC
Sequence: MEVMQVLHMNRGNGENSYAKNSTVQSKIISIGKPIIEEAVHEISCNNVLESMGIADLGCSSGPNTLCVISEIMDMVQATSHRLGHPVPEFRLYLNDLYSNDFNSIFMSLPAFYHRLKEEKGIGCGSCFISGVAGSFYGRLFPSKSLHYVHSSSSLHWLSQVPPGLESNAVTPLNKGKVYISKSSPHSVLHAYSLQFQNDFPMFIESRSQELVSGGRMVLSLFGRRSTDPTTEESCYQWELLAQAIMSLVREGLIEEEKVDSFNTPFYAPCAEEIKVEIQKEGSFIIDRLEGFEIDWDGGAVSDVHTAQGKLLIGQRAAKALRAVVESMLESHFGIGQDIMDDLFSRYAEIVGNHLSKTRTKYFNLVISLTRKG
What is the function of this protein?
Catalyzes the methylation of jasmonate into methyljasmonate, a plant volatile that acts as an important cellular regulator mediating diverse developmental processes and defense responses.
What are the official names of this protein?
Probable jasmonic acid carboxyl methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic (By similarity). Partially nuclear (By similarity).
Protein: ARL1_RAT
Sequence: MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTPSEMANALGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
What is the function of this protein?
GTP-binding protein.  Can activate phospholipase D with very low efficiency (By similarity).  Important for normal function of the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Lipid-anchor.
Protein: CYTM1_MOUSE
Sequence: MNPENPPPYPGPGPTAPYPPYPQQPMGPMGPMGAPPPQGYPYPPPQGYPYQGYPQYGWQGGPQEPPKTTVYVVEDQRRDDLGPSTCLTACWTALCCCCLWDMLT
What are the official names of this protein?
Cysteine-rich and transmembrane domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CYSTM1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PYRF_SALCH
Sequence: MTFTASSSSCAITESPVVVALDYHERDKALAFVDKIDPRDCRLKVGKEMFTLFGPQLVRDLQQRGFDVFLDLKFHDIPNTTARAVAAAADLGVWMVNVHASGGARMMAAARDALAPFGKDAPLLIAVTVLTSMETSDLRDLGVTLSPAEHAERLVRLTQQCGLDGVVCSAQEAVRFKQVFGAAFKLVTPGIRPAGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKDINASLKREA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: ARGB_BRUMB
Sequence: MTTLENPEMQAQLLSAALPYMQRYENKHVVVKYGGHAMGNPELGKAFARDVALLKQSGVNPIVVHGGGPQIQAMLTKLGIESRFEGGLRVTDEKTVEVVEMVLAGSINKEIVALINAEGEWAIGLCGKDGNMVFAQKAHKTVIDPDSNIEKVLDLGFVGEPAEVDRTLLDLLARSEMIPVIAPVAPGRDGHTYNINADTFAGAIAGALAATRLLFLTNVPGVLDKDKKLIKELSVADAQALIRDGTISGGMIPKVETCIDAIRRGVEGVVILNGKTPHSVLLELFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECPA_STAEQ
Sequence: MKKKLSYMITIMLAFTLSLALGLFFNSAHADSLPQKNGANQKTTKVTVSNKDVPDAVRKLAEEQYLSRVALLDKASNHKATSYTLGEPFKIYKFNKESDGNYYYPVLNKKGDVVYVVTISPNPSNSKASKQQNNYSINVSPFLSKILNQYKNQKITILTNTKGYFALTEDGKVTLVLKTPRNNEKTYENATESTKPKDLNDFKQTASVTKPTLEYQSTRNEMYAEYVNQLKNFRIRETQGYNSWCAGYTMSALLNATYNTNRYNAESVMRYLHPNLRGHDFQFTGLTSNEMLRFGRSQGRNTQYLNRMTSYNEVDQLTTNNQGIAVLGKRVESSDGIHAGHAMAVAGNAKVNNGQKVILIWNPWDNGLMTQDAHSNIIPVSNGDHYEWYASIYGY
What is the function of this protein?
Cysteine protease able to cleave elastin, insulin, myoglobin, fibronectin, fibrinogen, HMW-kininogen, alpha-1-protease inhibitor and alpha-1-antitrypsin.  Along with other extracellular proteases may contribute to the colonization and infection of human tissues (By similarity).
What are the official names of this protein?
Extracellular cysteine protease, Staphopain.
What is the protein family that this protein belongs to?
Belongs to the peptidase C47 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted.
Protein: MATK_IRIDA
Sequence: MEELQGYLEKDRSRQQPFXYPLLFQEYIYALAHDRGLKGSLFYEPTEVFGYDSKSSLALVKRLIIRIYQQNDFTSVVNDSNKNQFVNHHHNNFGYSHFYSQMISEGFAILVEIPFSLRLVSYFEKKEIPKSHNLRSIHSIFPFLEGKLXHLNYVSDILIPHPVHMEILIQILQCWIQDAPLLHFXRFFLHKXHNWBRFLXTPKESXYVFSKXNKRLFRFLYNSYVSECEFLLVFLRKKSSYLRLTSFGLFLERRHFYVKMEHLQMQHLILIVVCLDYXQGTLWSFXXXXXXXVRCQGXVVLASKGTHLLMKKWKYNFVNLWQYHFHFWYQSYRIHINQLSNYSLYFLGYLSSLLRNSSTVRNQMLENSFLIDTVTNKLETLVPVIFLIGSLSKAQFCTVSGHPISKPIWADLSDFEIIERFGRMCRNLSHYHSGSSKKQELHRIKYILRLSCARTLARKHKSTVRTFLRRLGSVLLEEFFTEEEQVLSLILPKAIPFTFYGSHKERIWHLDIIRINDLVNHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DKK1_MOUSE
Sequence: MMVVCAAAAVRFLAVFTMMALCSLPLLGASATLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPRGEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHFWSKICKPVLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQRH
What is the function of this protein?
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778).  Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087).  Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822).
What are the official names of this protein?
Dickkopf-related protein 1, Dickkopf-1, Dkk-1, mDkk-1.
What is the protein family that this protein belongs to?
Belongs to the dickkopf family.
What are the subcellular locations of this protein?
Secreted.
Protein: LYG1_MOUSE
Sequence: MSPLWLLLGLLALTGSSESSSWGCYGNIRTLDTPGASCRIGRRYGLTYCGVRASERLAEVDRPYLLRHQPTMRLVGQKYCMDPAVIAGVLSRESPGGNYVVDLGNIGSGLGMVKETKFYPPTAWKSETWVSQKTQTLTSSIKEIKTRFPTWTADQHLRGGLCAYSKGPNFVRSNQDLNCDFCNDVLARAKYFKDHGF
What are the official names of this protein?
Lysozyme g-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 23 family.
What are the subcellular locations of this protein?
Secreted.
Protein: VKT6_PSETT
Sequence: MSSGGLLLLLGLLTLWEVLTPVSSKDRPKFCELPADIGPCDDFTGAFHYSPREHECIEFIYGGCKGNANNFNTQEECESTCAA
What is the function of this protein?
Serine protease inhibitor (By similarity).  Does not inhibit plasmin, and does not reduce blood loss in the mouse tail vein blood loss model.
What are the official names of this protein?
Kunitz-type serine protease inhibitor textilinin-6, Txln-6.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: UGDH1_SOYBN
Sequence: MVKICCIGAGYVGGPTMAVIALKCPSIEVAVVDISKSRIAAWNSDQLPIYEPGLDGVVKQCRGKNLFFSTDVEKHVFEADIVFVSVNTPTKTQGLGAGKAADLTYWESAARMIADVSKSDKIVVEKSTVPVKTAEAIEKILTHNSKGIKFQILSNPEFLAEGTAIKDLFNPDRVLIGGRETPEGQKAIQTLKDVYAQWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGANVQQVSYSVGTDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVAEYWKQVIKINDYQKSRFVNRVVASMFNTVSNKKIAILGFAFKKDTGDTRETPAIDVCQGLLGDKANLSIYDPQVTEDQIQRDLSMNKFDWDHPIHLQPTSPTTVKKVSVVWDAYEATKDAHGLCILTEWDEFKTLDYQKIFDNMQKPAFVFDGRNIVDADKLREIGFIVYSIGKPLDPWLKDMPAVA
What is the function of this protein?
Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.
What are the official names of this protein?
UDP-glucose 6-dehydrogenase 1, UDP-Glc dehydrogenase 1, UDP-GlcDH 1, UDPGDH 1, Gm-UGD1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Protein: G6PI_CLOBH
Sequence: MKNSLSLDLTKTKPYVEEHELQYLESIIREMDNTLGKKTGSGNKFLGWMDLPINYNKEEFARIKKAAEKIKNTCDVFIVIGIGGSYLGSRAAIEMISNTFYNNLDKNQRKVPQIYFAGNNISSTYMADLLELVKDKDICVNVISKSGTTTEPAIAFRIFKELLENKYGKEGAKERIFATTDAAKGALRTLADSEGYETFVIPDDVGGRFSVLTPVGLLPIAASGIDIDEMMKGAADAREEYSSDNIEKNHVYRYVAVRNALYRKGKTTEMLVNFEPCLHYFGEWWKQLYGESEGKDGKGIFPAAADFSTDLHSMGQYIQEGLRNIFETFINVENPRKSIIVKEDKENLDGLNFLADKDMDYVNHQALRGTVLAHNDGGVPAMVLNVPELSAYYFGQLVYFFEKACGISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYENMKATLEERLK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_PSEFS
Sequence: MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLICAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLLTAGAEGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEILFIRERLNTLMAKHSGHTLEEIERDTNRDNFMSAEAARDYGLIDAVIDKRPA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_MESHJ
Sequence: MKIKAKNIVKIYDQKLPSELKALDKVTTEINQGEFIAIIGQTGSGKTTFIQHMNALLLPDQGEIEYLYFDSKNQEKKLVVQKPRFFRKKLKFINEIRRRVGVVFQFAEYQLFEQTIEKDIIFGAVSMGTPKNEAKKIAAEIIELVGLDQSFLQKSPFELSGGQKRRVAIAGILAMDPDIIFFDEPTAGLDPQGTLKMLEILDTLYKKGKTIILATHDLDSVLEWTKRCIFFKDGRIIYDGDTYSILANNKFLIENKMLPTNLLNFREKLIKIGYPISNVRSVSELISEINMLIQKETNAD
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CD81_PANTR
Sequence: MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
What is the function of this protein?
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.  Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells.  Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production.  In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype.  Present in MHC class II compartments, may also play a role in antigen presentation (By similarity).  Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes.  Positively regulates sperm-egg fusion and may be involved in acrosome reaction.  In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity).  In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity).  Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity).  May regulate the compartmentalization of enzymatic activities.  In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity).  Also involved in cell adhesion and motility.  Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
What are the official names of this protein?
CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: ZRN1B_XENLA
Sequence: MTEDGIKWACEYCTFENWPSAIKCTMCRAPRPSGAIITEEPFKNRTPDVGSMEREIGSPLICPDSSARPRVKSSYSMETSSKWSCQICTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGLRSIPGPIDPCEEYNDRNKLNIKGQHWTCSACTYENCAKAKKCVVCDHPTPNNMDAIELANTDEASSIINEQDRARWRGGCSSSNSQRRSPPTSKRDSDMDFQRIELAGAVGSKEEFELDLKKLKQIKNRMRKTDWLFLNACVGVVEGDLSAVEAYKTSGGDIARQLSADEVRLLNRPSAFDVGYTLVHLSIRFQRQDMLAILLTEVAQHAAKCIPAMVCPELTEQIRREIAASVHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELGTRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLRDCSHWFYSRWKEWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGFDNRGAGANLNTDDDVTVTFLPLVDSERKLLHVHFLSAQELGNEDQQEKLLREWMDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDGYRQIRPCTALSDGEEDEDDEDE
What is the function of this protein?
Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity).  Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity).  Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity).  Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity).  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Required in the stress fiber dynamics and cell migration (By similarity).
What are the official names of this protein?
Ubiquitin thioesterase zranb1-B, Zinc finger Ran-binding domain-containing protein 1B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C64 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.
Protein: RS9_METEP
Sequence: MATLQSLADLNRANTQTSNPENEAPVHVQKLDAQGRAYATGKRKDAVARVWIKPGNGTVVVNGRPVETYFARPVLRMILRQPLEIVSRVDQYDITVTVKGGGLSGQAGAVRHGLSKALTYYEPELRSSLKREGFLTRDPRVVERKKYGRKKARRSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: DNAJ_KLEP3
Sequence: MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEILTDAQKRAAYDQYGHAAFEQGGMGGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKAGSKPQTCPTCHGAGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVEKTKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFTMAALGGEIEVPTLDGRVSLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLKELQESFGGPTGENNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGMG2_BURL3
Sequence: MFTARVARPMAGDDAPAASSGSTGSSAPPASSAADCVLEVRGVGKSFPGVVALDGVQFRVRRGTVHALMGENGAGKSTLMKIIAGVYTPDQGEILINGEPVVLNGPLDALDRGIAMIHQELNLMPYMTVAENIWIRREPKNRFGLIDHAALRRQTAELFERLSIDIDPETDVRTLTVASRQMVEIAKAVSFDSDVLIMDEPTSALTDKEVTHLFRIIRQLREQGKGIVYITHKMNELFEIADEFSVFRDGKYIGTHASSDVTRDDIIRMMVGREITQMFPKEEVPIGDVVLSVKNLGVDGVFRDVSFELRAGEILGVAGLVGSGRSNVAEALFGVVPATSGEIRIDGKPVRITTPGQAMKHGMAFLTEDRKDTGCFLNLDLLANMEAAVLSNRYVKFNFVRQAQLKRDCEEMSRMLRVKSPGLHEEIQNLSGGNQQKVLIGRWLLTQPRILILDEPTRGIDVGAKAEIHRLVSALAGKGVAVLMISSEMPEVLGMSDRVMVMHEGRMTGIVDRKDADQVRIMDLASR
What is the function of this protein?
Part of an ABC transporter complex involved in carbohydrate import.  Could be involved in ribose, galactose and/or methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Putative ribose/galactose/methyl galactoside import ATP-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNT_PSEF5
Sequence: MSDDHFDDEQEGSSGGPRHPMAARFRGYLPVVVDVETGGFNSATDALLEIAATTIGMDEKGFVFPEHTYFFRVEPFEGANIEAAALEFTGIKLDHPLRMAVSEETALTDIFRGVRKALKANGCKRAILVGHNSSFDLGFLNAAVARLDMKRNPFHPFSSFDTATLAGLAYGQTVLAKACQSADIDFDGREAHSARYDTEKTAELFCGIVNRWKQMGGWQDFDD
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.