PharMolix/UniProtQA huggingface dataset:
Protein: TTL3B_DROME
Sequence: MTTQNTTPAGFTGNRNRYYNPVSKIQSLIHNLDAELVQLCKQCSVQKPLTSLNNSTSLGSHFSNFGALGGGSGSKTMGGSSSMGSNNFSPDSIGNLLARVRASTPLPRTVTSSPTAPEAQKRQMRNVYRTRVIDAYRNRRIFTVYGNYHTVRRALMRRGWLEKLPASRHAKLQSMSEDALLEHARRGNDYEAVVISKMINHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLDFSTKVGLVGCAEQERWYREDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVREHQPAELISENGTIFSTTLDFALGKVKKMVRHAEHYSLDDARIKPPTPAEIVENQTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQIESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNNQNKKYIVQKYIERPLLIYRTKFDIRQYMLLTITDTKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSVQKRYKNKTNRDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELLQNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLFELAFEVNYSINKGADGKPLELNGKQMTLFENMPRMRNSPRTRLLRKILNNVKTSTTKKVEKVVEAPAKNVKNPTAKITKKKKLSASAGSSTAASAQPSTQNLTTKLILNPATRENLALQYTAPK
What is the function of this protein?
Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins.  Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin.  Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T).  Required for early steps of spermatogenesis.
What are the official names of this protein?
Tubulin glycylase 3B, dmTTLL3B.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus.
Protein: CCME2_XANOM
Sequence: MNPQRRRRLWWVLALLLAGGLATTLVSMALQRNVAYLYTPSEVLRGDAGENSRFRLGGMVEKGSFQRASGALEAHFRVTDGDAQLPVSYDRILPDLFREGQAVVATGRMQSGVFVAEDVLAKHDETYMPKEVADKMGSAHRKHDVPAAANQGGALR
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE 2, Cytochrome c maturation protein E 2, Heme chaperone CcmE 2.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RBFA_CHLCH
Sequence: MSRRTERVASLLQHELGAIFQLELPRTPIVTIVEVKVTVDLGIARVYISTIGTPEEQAAIMAHLQEQNKYIRKLLSQRIRHQFRRIPELEFYEDHLYEHARHIEQLLSQVRKAPVDDAETPLD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLH_NEOFI
Sequence: MTAKFDVDYVLANITEDDKIALLSGSDFWHTHAIPKFNVPPIRTTDGPNGIRGTKFFAGVPAACLPCGTALGATWDRDLLHQAGVLLGKECLAKGAHCWLGPTINMQRSPLGGRGFESFAEDPHLSGIMAKSIILGCESTGVISTVKHYVGNDQEHERRAVDVLVTPRALREIYLRPFQIVARDAHPGALMTSYNKINGKHVVENPAMLDIVRKDWNWDPLIMSDWLGTYTTIDSMNAGLDLEMPGPTRYRGKYIESAMQARLIKQSTINKRARKVLEFVQRASRAPVSADETGRDFPEDRALNRTLCANSIVLLKNDGNLLPIPKTVKKIALIGSHVKTPAISGGGSASLEPYYAVSLYDAVVEALPDAKILYEAGAYAHKMLPVIDRMLSNAVIHFYNEPPEKERTLLATEPVVNTAFQLMDYNAPGLNRGLFWATLIGEFTPDVSGLWDFGLTVFGTATLFVDDEMVIDNTTRQTRGTAFFGKGTVQEVGQKQLTAGQTYKIRIEFGSANTSPMKAIGVVHFGGGAAHLGACLHMDPEQMVANAVKVAAEADYTIVCTGLNRDWESEGFDRPDMDLPPGIDALISSVLDLAADRTVIVNQSGTPVTLPWADRARGVVQAWYGGNETGHGIADVLFGDVNPCGKLPLSWPVDVKHNPAYLNNMSVGGRMLYGEDVYMGYRFYEKVGREVLFPFGHGLSYTTFSVSPEATVSPSVFSSDSPPTARVLVKNTGPVAGAQILQLYIAAPNSATPRPVKELHGFTKVFLQPGEERTVAIHIDKYATSFWDEIEDMWKSEEGVYQVLIGTSSQEIVSRGEFRVEQTRYWRGV
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase H, Beta-D-glucoside glucohydrolase H, Cellobiase H, Gentiobiase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAB_BURVG
Sequence: MTKKVYVKTFGCQMNEYDSDKMVDVLNAAEGLEKTDTPEDADIILFNTCSVREKAQEKVFSDLGRVRELKEAKPGLLIGVGGCVASQEGASIVSRAPYVDLVFGPQTLHRLPQMIDARRASGRAQVDITFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGDEVSRPLDDVLTEVAGLADQGVREVTLLGQNVNAYRGALSAGSADIADFATLIEYVADIPGIERIRYTTSHPKEFTQRLIDTYAKVPKLVSHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPDLSLSTDMIVGFPGETEDDFDKMMALVHEMSYDTSFSFIYSPRPGTPAANLHDDTPREVKLKRLQHLQATIEENVARISQSMVGKVERILVEGPSRKDPNELSGRTENNRVVNFPAPLASHPRLIGQMIDVKINHAYPHSLRGELLLVSDDASAATH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGL27_ARATH
Sequence: MTQRKNMYSKKNSFGRSDFPEGFLFGTASSAYQYEGARNEAPRGESVWDTFVRKYPERNCYSNADQAIEFYNHYKDDIQRMKDINMDAFRFSISWPRIFPLGKKSKGVNKEGIQFYNDLIDELLANGITPLATLFHWDTPQALEDEYSGFLSEEAVDDFKDFAALCFEEFGDRVKLWVTLNEPWVYSIGGYDTGRKAPGRASKYMNEAAVAGESGLEVYTVSHNLLLAHAEAVEVFRNNPKCKDGKIGIAHCPVWFEPYDSNCPKDIEACERAMEFMFGWHMDPTVYGDYPAVMKKSIGKRLPSFTAAQSKKLRGSFDFVGVNYYSAFYVKNIDEVNHDKPNWRSDARIEWRKENNAGQTLGVRGGSEWDFLYPQGLRKFLNYAKNKYESPKFMITENGHCDIDYEKKPKLSNLMDLQRTEYHKKHLQSIQQAIQEDGVVVEGYFAWSLLDNCEWNAGYGVRYGLFYVDYNNGLKRFPKMSAMWFKEFLKREEEIEDSEEEEYVLKSTMNKKRFLLATGSSASCFIPKMSESSKALELLF
What are the official names of this protein?
Beta-glucosidase 27, AtBGLU27.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: RET2_MOUSE
Sequence: MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIITQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRHVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK
What is the function of this protein?
Intracellular transport of retinol.
What are the official names of this protein?
Retinol-binding protein 2, Cellular retinol-binding protein II, CRBP-II.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPYR_YERPE
Sequence: MSLNQVPAGKDLPEDIYVVIEIPANADPIKYEIDKETGSLFVDRFMSTAMFYPCNYGYINNTLSLDGDPVDVLVPTPYPLQPGSVIRCRPVGVLKMTDEAGEDAKLVAVPHSKLTKEYDHVKDVQDLPELLKAQIKHFFEHYKDLETGKWVKVDGWEDAAAAKAEILSSFERAKK
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_THET2
Sequence: MRPGLSAKRLVVKVGSAVLTGERGLDLEAMAEIARQVAALREEGREVVLVSSGAVAAGMRRLGLKERPKDMPKKQALAALGQPLLMAFWQEAFAPFGLPVAQVLLTAEDLSSRSRYLNAKATLRALLDLGAIPVINENDTVAFEEIRFGDNDQLSARVAALVEAGLLALLSDVDALYEEDPKKNPQARPIPEVESVEAVLAHAGEENPLGSGGMKSKLLAARIAGRVGIPTLLLPGKRPGVLLQALSGAPLGTYFHARRRYRGEKAWLFGLLRPKGELVLDRGAVRALKERGASLLPAGVKEVRGRFSRGEAVRLLSEEGEEVGVGLANYASEEIARIKGRRSAEIEAVLGYRYTEEVVHRDHLALKEEA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8E_METB6
Sequence: MLWQGESIRKVTGGRRRPAQGKRRFEIGLAPADTHIGEDRSKLVRTTGGNTKIRSMRAQFANVTNLANGETKKVKIENVEENGANPNYVRRNLLTKGAIIRTEIGRARIMSRPGQDGIINAVLLA
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: MIC60_ASPFC
Sequence: MLRSSFTQSRQLLLSQARSRTAAQWLPKAGASNRLAGQRFFADAKPPVTGAPTPASPSSESSIPPETVPKPSPAAEAPLPPPPPPAPARKTGRFRKFLLYLILTSGFAYGGGIFLALKSDNFHDFFTEYVPYGEDCVLYFEERDFYRRFPNTLRNQNRAPKDEGHTVTIPSKSGLSWKVAEEESGADVSQKGPHMSALDNGDKAQLKPGAAKPEEKVATVEKVKAESAAKEQTAEDKKKVKEEPKKPAAPAVTPIEFATVSEGDEEVVQELVKTFNDIITVIGADENAHKFSGAVNKAKEELRTIGEKIIAIRNEARKAAQEEIKQAHATFDESARELIRRFEEARAHDAAQYREEFEAERERLARAYQEKVNTELQRAQEVAEQRLKNELVEQAIELNRKYLHEVKDLVEREREGRLSKLNELTANVNLLEKLTTDWKEVIDTNLKTQQLQVAVDAVRSVLERSTVPRPFVRELVAVKELAAGDPVVEAAIASINPTAYQRGIPSTSQIIERFRRVADEVRKASLLPEDAGIASHAASLVLSKVMFKKDAVAGSDDVESVLLRTEHLLEEGNLDDAAREMNTLKGWAKILSKDWLSDVRRVLEVKQALEVRLGPFTSLFHLYR
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit mic60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DAPC_MYCTO
Sequence: MTVSRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRLSVLAERPAT
What is the function of this protein?
Involved in the lysine biosynthetic pathways.  It catalyzes the transfer of an amino group from L-glutamate to N-succinyl-2-l-amino-6-oxoheptanedioate (N-succinyl-2-l-amino-6-ketopimelate) in a PLP-dependent reaction, yielding as products N-succinyl-l-2,6-diaminoheptanedioate (N-succinyl-diaminopimelate) and 2-oxoglutarate (By similarity).
What are the official names of this protein?
Probable N-succinyldiaminopimelate aminotransferase DapC, DAP-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_TETNG
Sequence: MASLRKTHPLMKIANDMVVDLPTPSNISAWWNFGSLLGLCLVAQILTGLFLAMHYTSDIATAFSSVAHICRDVNYGWLIRNLHANGASFFFICLYLHIGRGLYYGSYLQKETWNIGVVLLLLVMATAFVGYVLPWGQMSFWGATVITNLLSAVPYVGNTLVQWVWGGFSVDHATLTRFFAFHFLLPFIVAAAVIVHLIFLHETGSNNPLGLNSDTDKIPFHPYFSYKDLIGFTVLLTTLTMLALFSPNYLGDPDNFTPANPLVTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLASILRLMEVPLLHTSKKRKPYFSDPLTNFLFWTLIGRMWPSSPESEACLVEHPYVIIGQAASILYFSLFLVLMPAAGWLENKTLQ
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CA427_CONBU
Sequence: ASDGRNAVVHERAPELVVTATTTCCGYDPMTICPPCMCTHSCPPKRKPGRRND
What is the function of this protein?
Probable neurotoxin with ion channel inhibitor activity.
What are the official names of this protein?
Conotoxin Bu27, KappaA-conotoxin Bu27.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PURL_CHLL3
Sequence: MKTIEPEVNLALAAEHGLNAEEYQKIQEVLGRTPTFTELGIFSVMWSEHCSYKNSIAVLKTLPREGEALLTGAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVASLNSLRFGSPKDPRVRYLVDGVVRGIGDYGNSFGVPTVGGEIYFEDCYTGNPLVNAMSVGIVEHHKTVSATAEGEGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQVGDPFAEKLLLEATLEAIATGYVAGLQDMGAAGITSSTSEMSARGIEKNGNGGITIDLDLVPAREAGMSAYEIMLSESQERMLIVAEKGHEDDIIAVYRKWDVQAVVVGTVTSDNHVKVLHHGELVADIPAESLVLGGGAPVYIREAVGKKPDTAPAALLPDAGLDLRALALELLKRPNIASKRWVYRQYDSMVQTNTVTPVGHTDAAVIRIRGTKKGLAMKTDCNSRYVYLNPLAGGRIAVAECARNIACSGARPLAITNCLNFGNPYKPEVYFQFKTSVQGMGDACRAFNTPVTGGNVSFYNESTHGGGRAAIYPTPTIGMIGLLDDIDNLVGSAFTTAGDAIILFGDPLLKLEGSEFQVMQYGTPGTDAPDIDLQHEKNLQDLLVTLAEQKLLHSAHDVSDGGLFVTLAEKAIMDESRQLGFQVDLEDCGSGPYRVQEQLFSEAQGRVVGTIAPDAARAVIEEAIRHSVPVRVIGQVVPADASLAVDGHETLRFTTEELTAAYYDALENALHLNELL
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_STRPG
Sequence: MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFGDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: DNAS1_BOVIN
Sequence: MRGTRLMGLLLALAGLLQLGLSLKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEVRDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYDDGCESCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKWHLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADTTATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDHYPVEVTLT
What is the function of this protein?
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459).  Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity).  Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459).  Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459).  Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity).  NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).  Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
What are the official names of this protein?
Deoxyribonuclease-1, Deoxyribonuclease I, DNase I.
What is the protein family that this protein belongs to?
Belongs to the DNase I family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Protein: HIS8_SALTI
Sequence: MSTENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSAETIGVERRTVPALENWQLDLQGISDNLDGAKVVFVCSPNNPTGQLINPQDLRTLLELTRGKAIVVADEAYIEFCPQATLAGWLVKYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLLKVIAPYPLSTPVADIAAQALSPQGINVMRDRVAQTVQERQYLVNALQQTACVEHVFDSETNYILARFTASSSVFKSLWDQGIILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: GNAI1_CAVPO
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity).  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity).  The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  Required for normal cytokinesis during mitosis (By similarity).  Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-1, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.
Protein: CYB_MESMC
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVAALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSTLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPVLHVSKQRSMMFRPLSQCLFWLLVSVLFTLTWIGGQPVEHPYIIIGQTASVLYFLIILVLMPAISLIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NCPP_SULIM
Sequence: MVTIALGSRNPVKINATKEALDVLKLNWDLIGIEVDNGVDKQPFCDQTYVGARNRALNVIRVTNADIGLGIEGGVCNVYGKFIANAVVYVITKEGLENFAISSSFTLPSSMVSLILQGKELGEASDIIFKTNNSKTKEGAIGLLTNNVINRKMLYVQPIVLALYPIYNTMINNTPF
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Probable inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: TPO1_YEAST
Sequence: MSDHSPISNKENHLLPSDSSRSSSSDMHSTGTTGTTGVEPVDFTGEGAKYTTATEGNGGADLAIQRTTTMNSAAESEVNITRRLTKILTGSVNEPDRVEVDYTNCAPMGGDRPYPPSLPSRDLYEVTFDGPNDPLHPFNWPMKKKVLLCLVLCLDSIAIAMCSSIFASAVPQICEIYHVIEVVAILGITLFVLGFAASPVIYAPLSELYGRKGVLVLSAFGFALFQFAVATAENLQTIFICRFFGGFIGAAPMAVVPAAFADMFDTNVRGKAIALFSLGVFVGPILSPVMGSYIAQRTTWRWLEYVVGCFASAVFVAIVLFFEETHHPTILVNKAKQMRKQSNNWGIHAAHEDVELSIKDIVQKTVTRPIIMLFVEPLLLFVTIYNSFVYGILYLLLEAYPLVFVEGYGFTENGELPYIALIIGMMVCAAFIWYMDNDYLKRCRAKGKLVPEARLYAMVIAGTVFPIGILWFCWTGYYPHKIHWMVPTVGGAFIGFGLMGIFLPCLNYIIESYLLLAASAVAANTFMRSAFGACFPLFAGYMFRGMGIGWAGLLLGLFAAAMIPVPLLFLKYGESIRKKSKYAYAA
What is the function of this protein?
Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm.  Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH.  Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide.  Confers resistance to the non-steroidal anti-inflammatory drug indomethacin.
What are the official names of this protein?
Polyamine transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Enriched on the cell membrane of growing buds.
Protein: TAL_BRUAB
Sequence: MKFFVDTADVKEIRELNDLGLVDGVTTNPSLILKSGRDIIEVTKEICNIVKGPVSAEVAATEYEQMMKEAAVIARIADNICIKLPVTLDGLKACKALTSEGHKVNMTLCFSANQALLAAKAGATFISPFIGRLDDTGINGMELIAEIRTIYDNYDFRTEILAASVRTVNHVKEAALIGADVVTAPPATLKALVKHPLTDKGLETFLADWAKTGQKIA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.