PharMolix/UniProtQA huggingface dataset:
Protein: RF1_STRGC
Sequence: MNIYEQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASTRDTVTAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAQLFAGDLLQMYQKYAESQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEIEEVEYDIDPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILAGKLDEVVDALVLYDQTQKLEELNK
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYTC_METS5
Sequence: MESYRGLWLKGAIVMALNMYEAGLTPVEIGLGERDFYIDVQSDSALSLQESEKFAQWKDHKYEIKDGKVTYNGKQILLQGDVTPSGEPRYFKVLNISVHHPSANVQLVRIRGIAFETKEQMDDYLQWLEKASETDHRIIGERMDLFSFHEESGPGLVLFHPKGQLIRNEMINYMREINASMGYQEVYTSHVFRTVLWKISGHYDTYRDKMLIFQKDDDELGIKPMNCPAHILIYKSRVRSYRDLPIRFSEFGNVYRWEKKGELYGLLRTRGFTQDDGHIFLREDQLKDEVKNLVRKTLDVLGKFGFKGEDVRINLSTRPDESIGSDEQWEKATKALLDVLKELNVPYVVKEKEGAFYGPKIDFDIRDSLNRWWQLSTIQVDFNLPERFKLEYVDEDGSKKRPVMVHRAIYGSLDRMIAILLEHFRGKLPTWLSPVQVRVLPISEDNLDYAKRVMDVLVQRGIRTEIDPSGETLSKRIKRGYDDGVPYLVIVGRKEASEEKVTIRARGNVEIKGVPLSRFVDELSLEIGNRDAENTLIKRIG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.
What are the official names of this protein?
Threonine--tRNA ligase catalytic subunit, Threonyl-tRNA synthetase catalytic subunit, ThrRS-cat.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFAP_ECOLI
Sequence: MRKIFLPLLLVALSPVAHSEGVQEVEIDAPLSGWHPAEGEDASFSQSINYPASSVNMADDQNISAQIRGKIKNYAAAGKVQQGRLVVNGASMPQRIESDGSFARPYIFTEGSNSVQVISPDGQSRQKMQFYSTPGTGTIRARLRLVLSWDTDNTDLDLHVVTPDGEHAWYGNTVLKNSGALDMDVTTGYGPEIFAMPAPIHGRYQVYINYYGGRSETELTTAQLTLITDEGSVNEKQETFIVPMRNAGELTLVKSFDW
What are the official names of this protein?
Uncharacterized protein YfaP.
Protein: MRNC_BACSU
Sequence: MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPNDLHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYSTAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT
What is the function of this protein?
Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor.  Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.  Cleaves more efficiently on assembled 50S ribosomal subunits.  Cleavage is strongly stimulated by ribosomal protein L3 (RplC); 20-30% DMSO can replace RplC, suggesting RplC may alter rRNA conformation.
What are the official names of this protein?
Mini-ribonuclease 3, Mini-3, Mini-RNase 3, Mini-RNase III, Mini-III.
What is the protein family that this protein belongs to?
Belongs to the MrnC RNase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_PSYA2
Sequence: MKVQASVKKICGSCKVVRRKGRVHVICTAEPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LIPA_SHESW
Sequence: MNRPERLQPGVKLRDADKVSRIPVKIVPSERDTMLRKPDWLRVKLPASNQRILDIKQALRSNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPLKPDAEEPVKLAQTIRDMKLKYVVITSVDRDDLRDGGAQHFADCIREIRKLNPAIKIEILVPDFRGRIDAALDILATEPPDVFNHNLETAPMHYRKARPGANYQWSLDLLKRFKERHPNVPTKSGLMMGLGETNEEIAQVLRDLREHKVEMLTLGQYLQPSKFHLPVERYVPPAEFDELKALADELGFTHAACGPLVRSSYHADLQAQGKEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IIGP1_MOUSE
Sequence: MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN
What is the function of this protein?
GTPase with low activity.  Has higher affinity for GDP than for GTP.  Plays a role in resistance to intracellular pathogens.  Required for disruption of the parasitophorous vacuole formed following T. gondii infection and subsequent killing of the parasite.  Mediates resistance to C. trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.
What are the official names of this protein?
Interferon-inducible GTPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells.
Protein: PSRP_ALKEH
Sequence: MTEARRSVYFISDRTGITAEALGHSLLTQFSIDFEQRTIPFVDTEEKAAQVVEQLNVASQRSGLRPIVFSTVVDAEVRRVLQTTDAVLFDFFDTFIAPLEQELRMPSSHVIGRSHGVVDNNMYDVRIDAMNYALNHDDGAVTHHYSRADVILTAVSRSGKTPTCIYLALQYGIYAANYPLTQDDLNRGKLPRKLVEHKRKLYGLTINVDRLQTIRSGRLPNSDYASLRQCSYEVARAEALFRSEGIPYVNTTTMSIEEIATKIIHEAKLERRLY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: PQQD_PSEPW
Sequence: MSFDRKQVPNWRPGYRFQYEPAQKGHVLLYPEGMIKLNDSASLIGGLIDGKRDVNAIITELEQQFPGVPEVADDIEQFMEVARGEHWITLA
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: PSBN_SOLBU
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CORZ_ANOGA
Sequence: MLHTRTIALLLVGLVVLVNAQTFQYSRGWTNGKRSPLSSSSSSPSSSAAMEPLTANQLLASALSSGGLNSLKPSEKALLRRFLRNPCDLRVASLLAAAHPTKELFPLAGNSFDSAESAGAAFVLPPFLMDPDESNGGIGGSNLANGRSMEDELRFKRGTATGFSDHRQKIA
What is the function of this protein?
Cardioactive peptide.  Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
What are the official names of this protein?
Pro-corazonin, Crz.
What is the protein family that this protein belongs to?
Belongs to the corazonin family.
What are the subcellular locations of this protein?
[Corazonin]: Secreted. SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted.
Protein: PIGS_BOVIN
Sequence: MAATGAAATDLEVVRGKRAALFFATVVIVLGLPLWWKTTETYRAPLPYSQISGLNSLKLRLMVPVTVVFTQESVPLDDQEKLPFTVVHEREIPLKYKLKIKCRFQKAYRRALDHEEAALSLGNIQEAEAMLAEPSEQAEGSLTVYVISERCSLLPQDMMSYIGPKRMAVVRGITHREAFNIIGRRIIQVVQAMSLTEDVLAAALADHLPEDKWSSDKRRPLKSSLGYEITFSLLNPDPKSHDVHWDIEGAVRRYVQPFLSALSAAGNFSVDSQILYYAVLGVNPRFDSASSSYYLAAHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDPKAYNGSQLPVRVEVDMMRVMEVFLAQLRLLFGIAQPQLPPKCLFFGPKSEGIMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYRAVAAVQKAAEELSSGHLASAFAASQEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLFKIFLETRKSWKKPEKTD
What is the function of this protein?
Component of the GPI transamidase complex.  Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity).
What are the official names of this protein?
GPI transamidase component PIG-S, Phosphatidylinositol-glycan biosynthesis class S protein.
What is the protein family that this protein belongs to?
Belongs to the PIGS family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RNY_TREDE
Sequence: MNWILYVILPAVCIILGWTIRWLYARFQLSASEQRAERILQEAIKDAEAQKKEFLLEAKEQLIREQKQQERENRERRSDLQRFERRLAQKEEVLDKRVETVEKQEKELIKREAALDERTEILSGEEERYREELERISGLTQQQAKDLIIRDLEAEAKHDAVTIINKIEQEAQLTAEKKAQDILITTIQRLATETASDITVSTVSLPSDEMKGRIIGREGRNIRALETLTGVDIIIDDTPEAVVVSCFDPVRKEIARVALERLILDGRIHPARIEEIVQKVTREISQKVYEEGEKVLFDLGIHNMNQEGVRALGRLYFRTSYGQNVLQHSKEVAIIAGMIASEIGANVEIAKRGALLHDIGKGAETDSDKNHAEIGMELAKRINEDPRVVNAVGAHHNDIEPTCIESVIVQIADAISAARPGARRETMDNYVKRLENLEQLAEGFNGVEKAYAIQAGRELRVVINNEKISDADTKILARDIAKKIENDLQYPGRIRVTLIRETRIVEYAR
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL44E_METJA
Sequence: MKIPKKVRRYCPYCKKHTIHIVEKAKKGKPSELTWGQRQFRRVTAGYGGFPRPLPDRSKPVKKIDLRFKCTECGKMHTKANGCFRSGRFEFVEK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L44e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
Protein: DBH_STAAW
Sequence: MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKGRNPQTGKEIDIPASKVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: SYK_SYNY3
Sequence: MADSHSHSSLEEIRATRLEKAEQLRQLGLNPYAYTWEITHQAQDLQETYRDLSNGEEVDLKVAIAGRILARRVMGKLAFFTLQDESGTIQLYLEKQRLTEHMPELENAFNLLKKITDVGDILGVTGTLKRTEKGELSVYVQTYAVLTKSLLPLPDKWHGLTDTEKRYRQRYVDLIVNPTVRQTFRRRAQITAAIRRYLDKQGFIEIETPVLQGESGGAEARPFITHHNTLGMPLYLRIATELHLKRLVVGGFEKVFELGRIFRNEGVSTRHNPEFTSIEVYQAYVDYNEMMALTEALVTTAAQAVLGTLKITYQGEEIDLTPPWKRITMHEAVQLETGIDFSQFTDLETAKQAATKAGIGVPEDCPSLGHLLNHAFEQKVEGTLMQPTFIIDFPVEISPLAKPHRSKPGLVERFELFVYGRELANSFSELTDPIDQRSRLEAQAAKKAAGDLEAHSVDEDFLTALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVIAFPLLKNQEAGSDG
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_BORA1
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLQVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRRVNNFTTGQIYESVLRKERRGDYLGKTVQVIPHITNEIQDFVARGADSAWQGNTDVAIVEIGGTVGDIESLPFLEAARQMSLRMGRNSAAFVHLTLVPYIASAGELKTKPTQHSVQKLREIGIYPNALLCRADRRIPDDERAKISMFSNVPLDAVISVWDVDSIYKIPAMLHQQGVDNIVCEALGLTPPPADLSMWDNLVDALEHPQHEVTIGMVGKYVDLTESYKSLSEALVHAGIHTRSKVKIEYIDSEDIEARGTEQLKHLDAILVPGGFGKRGTEGKIAAIRYARENGVPYLGICLGMQLAVIEFARHVAGLGGANSTEFDPSAPHPVVALITEWMDREGKVEKRDTNSDLGGTMRKGAQRCPIKPGTLAQSIYGDDVNERHRHRYEVNNVYVPRLEAAGLVISARTPTENLPEMMELPNHPWFVGVQFHPEFTSTPRDGHPLFSSYIRAALESKNRRDPQA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: FOLD_ACTP2
Sequence: MTAHIISGTAVAKQVKANIAEQIQAYTAQDKRKPGLAVILVGMDPASQVYVNSKRKSCAEIGIESKSYDLPAETGEAELLAIIEQLNHDDSVDGILVQLPLPKQIDATKVTEAIVPHKDVDGFHPYNVGRLCQKIPTLRSCTPYGVMKLLESTGVNLAGLHAVVVGASNIVGRPMAMELLLAGCTVTITHSRTKDLAYHVSQADIVVAGVGKPNFVKGEWIKPGAIVIDVGINRVEGKLIGDVEYSAAEAKASFITPVPGGVGPMTVAMLMQNTLQAYQVHLQAV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SYC_NOCFA
Sequence: MTLRLFDTESRTMREFAPLVPGRASVYLCGATVQGEPHIGHVRSGVAFDVLRRWLQAHDYDVWFIRNVTDIDDKILNKAAEAGRPWWEWAATYERAFDRAYRLLGVQPPSAEPRATGHITQMVELMRRLIERGHAYASAGNVYFDVQSYPEYGALSGHKLDDVHQGESAGEGKRDPRDFTLWKAAKPGEPSWPSPWGPGRPGWHLECSAMAEFYLGAEFDIHCGGMDLVFPHHENEIAQSKAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLSVPNMLTKVRAVELRFYLGSAHYRSMLEYSDKALDDAVAGYQRIEAFLHRTAERVGEIPVGKWTDAFAEAMDDDLAVPRALAEVFRLVTEGNKALEAGAVDTARELGGQVRAMLGILGVCPFDPQWDHKQDDSVAQTALDVLVRAELDRRQQARADKDWATADAVRDRLHAAGIDVTDTPNGPEWSLRTARGKAN
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOX21_ORYSI
Sequence: MASNGMASSPSSFFPPNFLLHMAQQQAAPPHDPQEHHHHHHHGHHHEQQQHHHHLGPPPPPPPHPHNPFLPSSAQCPSLQEFRGMAPMLGKRPMSYGDGGGGGDEVNGGGEDELSDDGSQAGEKKRRLNVEQVRTLEKNFELGNKLEPERKMQLARALGLQPRQVAIWFQNRRARWKTKQLEKDYDALKRQLDAVKAENDALLNHNKKLQAEIVALKGREAASELINLNKETEASCSNRSENSSEINLDISRTPPPDAAALDAAPTAHHHHHGGGGGGGGGGGMIPFYTSIARPASGGGVDIDQLLHSSSGGAGGPKMEHHGGGGNVQAASVDTASFGNLLCGVDEPPPFWPWPDHQHFH
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein HOX21, HD-ZIP protein HOX21, Homeodomain transcription factor HOX21, OsHox21.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPG_STRA5
Sequence: MAGSLSEIKDKILSTEKTSKITSAMQMVSSAKLVKSEQAARDFQVYASKIRQITTNLLKSDLVSGSDNPMLSSRPVKKTGYIVITSDKGLVGGYNSKILKAMMDTITDYHTENDDYAIISIGSVGSDFFKARGMNVSFELRGLEDQPSFDQVGKIIAQAVEMYKNELFDELYVCYNHHVNSLTSQVRMQQMLPIKELDAEEASEDRVITGFELEPNREVILEQLLPQYTESLIYGAIIDAKTAEHAAGMTAMQTATDNAKNVINDLTIQYNRARQAAITQEITEIVAGANALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CXG1_MESAU
Sequence: MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction gamma-1 protein, Connexin-45, Cx45, Gap junction alpha-7 protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Gamma-type subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: GUAA_EHRCR
Sequence: MSRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTGMPPIVHDIIELNKKTSVPVLGVCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIKDVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAMISNEERRIYGVQFHPEVYHTPDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTYRAIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKRKIIGKTFIEVFEEEANKIGNVEFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIMKLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGLAIRIIGEITQEKVNMLQAADEIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPFGVDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: BECN_CAEEL
Sequence: MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALTGHSRNLMKLISDAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYINYLKENHPTTSIPDLKAKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAASEKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCFHIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI
What is the function of this protein?
Regulates autophagy (PubMed:12958363).  Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking (PubMed:16111945, PubMed:21183797, PubMed:26783301).  In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes (PubMed:26783301).  Involved in the clearance of engulfed apoptotic cell corpses (PubMed:16111945, PubMed:21183797).  Together with ced-9, negatively regulates somatic and germline apoptosis (PubMed:17890369).  Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797).  In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression (PubMed:28285998).  Required for embryonic development and L3/L4 molting during larval development (PubMed:16111945).  Required for normal dauer morphogenesis and lifespan (PubMed:12958363, PubMed:17204841).  Plays a role in male tail ray pattern formation (PubMed:17890369).  Required for normal survival when exposed to pathogenic bacteria S. typhimurium by promoting autophagic degradation of intracellular S. typhimurium (PubMed:19667176).
What are the official names of this protein?
Beclin homolog.
What is the protein family that this protein belongs to?
Belongs to the beclin family.
What are the subcellular locations of this protein?
Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Endosome. Note=Co-localizes with rme-8, a component of the retromer complex, on endosomes.
Protein: NADK_SHEHH
Sequence: MGINLKVSRPKAGSNINMSNTFHTIGLIGKPNHKGTTLTLKRLHHWLSMQGYKVLVEERVAGELGPQVQSVDLLEIGEQCDLAIVVGGDGNMLGAARVLARFSVGVIGVNRGNLGFLTDLPPDSFEEALSKVLEGEFEIEQRFLLEAEVHRHGELKSSNTAVNEAVLHPGKIAYMIEFEVYIDDKFMYSQRADGIIISTPTGSTAYSLSAGGAILTPNLSAVILVPMFPHTLSCRPIVVDAASIIKLVVSPHNSDNLEVSCDGHVHLSVLPGDEIIIKRSQETLRLVHPKGHNYFHVLRTKLGWGSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIM41_KLULA
Sequence: MLRCVIPSVRATATTRTFVRFASSQGYIDGIAALKQDLKKAMLAKDNLRKTTIRGVLSTIKNKEIDSKDKDLDEFVLYDVYAKLISQRKDSIAEFVKNKREDLVEKEANEIKILENYQTALPVASREEVDARVVQILTDLKESEPSIQLKQVFGKIDWKTLPGELKASPAAIRSSISSQFKKVFQ
What are the official names of this protein?
Altered inheritance of mitochondria protein 41, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ISPF_BACCQ
Sequence: MFRIGQGFDVHEFAEGRPLIIGGITIPHEKGLIGHSDADVLLHTIADACLGAIAAGDIGKHFPDTDPAFKDADSAVLLQKVWEFVREQGYELGNLDCTIIAQKPKMAPHIESMRKRISELLETSIDNINVKATTTEKLGFTGREEGIASQAVVLLQKK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PGXA_ASPNG
Sequence: MKLPILVTLFITLPALCVSSKTPSAPTISAYPKSPGNFKPASGRQNSTSNVCEVKPNQTDAAPGILAAAHTCNNGGTVFLPPGDFVVATALDLTFLNNIDFAIWGNITFKKDIDLWTTQAFQYTFQTASLFWRFGGNNVNIYGDGKGVIDGAGQYWWSAMAEDSSVMRPCLLGTDGLHHATISGLTMLNSPNWFNLIANSTDILISNMTMLVESEISDAPAKNTDGWDIYRSSNIVIQDSRIVNTDDCVSFKPNSTQIVIQNLDCTGSHGISVGSLGQYQGETDIVEDLYIYNISMTDASDVARIKVWPGVPADTSGSTSGGGLGRVRNVTYEHMQSENNDHIISVSQCYESKNQTMCDSYPSKLVIEDVLFKDFKGTTSKKYDPEIGELTCSSPDVCHNITVQDINVTPPSGDSPTFTCNNMGNSNLEDITCA
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Exopolygalacturonase A, Galacturan 1,4-alpha-galacturonidase A, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PHLB_SERLI
Sequence: MPEGRRLRRALAIALLALVAVTGLLMMAKEQQMGQEISPFDGHSNLALAQAVARGDTQGIHAQATQDRLRERGDRQVTLLQWAVLSQQPDSVQALLDLGADPAAAGLDGNSALHTAAMLQDAQYLRLLLAEGAQMNVRNAVTGATPLAAAVLAGREEQLRLLLAAGADTTLSDRLGDTPLHLAAKINRRTWRCCCCRPGPMPGRATSRASRSSFTSRKRRRICRMTN
What is the function of this protein?
Cell-protective protein that neutralizes the intracellular lysis capacity of phospholipase A1 through a direct interaction with the enzyme.
What are the official names of this protein?
Protein PhlB.