PharMolix/UniProtQA huggingface dataset:
Protein: ASP36_ARATH
Sequence: MVTTMDPSRISRIVAVVFVLVIQVVSGNFVFNVTHKFAGKEKQLSELKSHDSFRHARMLANIDLPLGGDSRADSIGLYFTKIKLGSPPKEYYVQVDTGSDILWVNCAPCPKCPVKTDLGIPLSLYDSKTSSTSKNVGCEDDFCSFIMQSETCGAKKPCSYHVVYGDGSTSDGDFIKDNITLEQVTGNLRTAPLAQEVVFGCGKNQSGQLGQTDSAVDGIMGFGQSNTSIISQLAAGGSTKRIFSHCLDNMNGGGIFAVGEVESPVVKTTPIVPNQVHYNVILKGMDVDGDPIDLPPSLASTNGDGGTIIDSGTTLAYLPQNLYNSLIEKITAKQQVKLHMVQETFACFSFTSNTDKAFPVVNLHFEDSLKLSVYPHDYLFSLREDMYCFGWQSGGMTTQDGADVILLGDLVLSNKLVVYDLENEVIGWADHNCSSSIKVKDGSGAAYQLGAENLISAASSVMNGTLVTLLSILIWVFHSFTS
What is the function of this protein?
Displays aspartic proteolytic activity (PubMed:27872247).  Together with A39, contributes to pollen and ovule development, including the apical cell wall constitution of the growing pollen tubes (PubMed:27872247).
What are the official names of this protein?
Aspartic proteinase 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm, cytosol. Note=Displays punctate cytosolic localization and colocalizes with the GPI-anchored protein COBL10 at the plasma membrane and in the cytosol (PubMed:27872247). In pollen grains, mainly present at the plasma membrane and in reticular structures in the cytosol (PubMed:27872247). In pollen tubes, exhibits a punctate localization in the cytosol and occurs weakly at the plasma membrane (PubMed:27872247).
Protein: RPOB_BORRA
Sequence: MIKRVHLGQGKAEEILNLPNLIEIQLNSYEKFLQLERLKNNKPLLNEGLESVFRDVFPMKSSNGEVALEYEKYYIEYDSISFTEKECKRKGQSYEAVLKIRLNLQFLTTGEIRQKDVYMGTIPLMTDRGTFIVNGAERVIVSQIHRSPGVVFYKEKDLYYARIIPYRGSWLEFEIDSKKDYLYVKIDRKKRILVTLFLRALGLDTREKIIETFYKIRKIEVNDDTKREITGQYLATNITIKENMTYRAGDKITLQDIEDFLQNGVKEINLIDFDGYDSVPGKHFISSDVILNCFEKEDAYFALKDGFKELSRESVMLAVYSVLLPGEPISIDNAENDLRTIFFSEKRYDLGHVGRYKLSKKFGLDDLTTSVLTMTDIVNTISHLLRIYDGHDVLDDIDHLGNRRVRSVGELLTNIYKGAMSRVEKIAKDRMSNKEVFNLKPQELISVKPVVSAVKEFFATSQLSQFMDQVNPLAELTHKRRLNALGPGGLSRDRAGFEVRDVHYTHYGRMCPIETPEGPNIGLIVSLATYSKVNDYGFLETPYRKVIDGKVTDDIEYLSAIDEEKKCIAQANASVSSDGNYTDDLVSVRISGDYTTMMPKNIDYMDVSPRQLISVSSALIPFLEHNDANRALMGSNMQRQAVPLLFPQPPIVGTGMERIVAKDSGVVIKAKRPGRVVLATNKKIVIKPDNATSERDLDEYELYKYERTNQDTSFNHSVLVKNGQIVNKDEIIADGPATRYGELALGNNLLVGFIPWNGFNYEDAILISERIVKEDLYTSIHIKEFSIEVRETKLGPEKVTADIPNVSGKILSKLDENGIVRIGTYVKPGDILIGKVTPKSEGDITPEFKLLTSIFGEKAKDVKNNSLKVPHGTEGTVIDVQRITKDDVGNLPPGVDEILKVYIAKKRKLKEGDKMAGRHGNKGVVAKILPVEDMPYLADGTPLDICLNPLGVPSRMNIGQLMESQLGLAGKYLGEYYDVPVFESATNECIQEKLKKAGFNETSKAVLYDGYTGEPFENEVMVGVIYMLKLHHLVDDKMHARSTGPYSLVSQQPLGGKAQFGGQRLGEMEVWALEAYGAAHTLQELLTVKSDDMSGRVKIYENIVKGIPTNVSGIPESFNVLMQELRGLGFDLSIYDDNGNQIPLTEKEEELINKT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: TILS_MYCTO
Sequence: MDRQSAVAQLRAAAEQFARVHLDACDRWSVGLSGGPDSLALTAVAARLWPTTALIVDHGLQPGSATVAETARIQAISLGCVDARVLCVQVGAAGGREAAARSARYSALEEHRDGPVLLAHTLDDQAETVLLGLGRGSGARSIAGMRPYDPPWCRPLLGVRRSVTHAACRELGLTAWQDPHNTDRRFTRTRLRTEVLPLLEDVLGGGVAEALARTATALREDTDLIDTIAAQALPGAAVAGSRGQELSTSALTALPDAVRRRVIRGWLLAGGATGLTDRQIRGVDRLVTAWRGQGGVAVGSTLRGQRLVAGRRDGVLVLRREPV
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBJD_ECOLI
Sequence: MILERVEIVGFRGINRLSLMLEQNNVLIGENAWGKSSLLDALTLLLSPESDLYHFERDDFWFPPGDINGREHHLHIILTFRESLPGRHRVRRYRPLEACWTPCTDGYHRIFYRLEGESAEDGSVMTLRSFLDKDGHPIDVEDINDQARHLVRLMPVLRLRDARFMRRIRNGTVPNVPNVEVTARQLDFLARELSSHPQNLSDGQIRQGLSAMVQLLEHYFSEQGAGQARYRLMRRRASNEQRSWRYLDIINRMIDRPGGRSYRVILLGLFATLLQAKGTLRLDKDARPLLLIEDPETRLHPIMLSVAWHLLNLLPLQRIATTNSGELLSLTPVEHVCRLVRESSRVAAWRLGPSGLSTEDSRRISFHIRFNRPSSLFARCWLLVEGETETWVINELARQCGHHFDAEGIKVIEFAQSGLKPLVKFARRMGIEWHVLVDGDEAGKKYAATVRSLLNNDREAEREHLTALPALDMEHFMYRQGFSDVFHRMAQIPENVPMNLRKIISKAIHRSSKPDLAIEVAMEAGRRGVDSVPTLLKKMFSRVLWLARGRAD
What are the official names of this protein?
Uncharacterized protein YbjD.
Protein: THIE_BACCR
Sequence: MARIEIDKMSKLLQVYFIMGSNNCTRDPLAVLKEALDGGVTIFQFREKGEGSLIGEDRVRFAKELQTLCNEYSVPFIVNDDVELAIELDADGVHVGQDDEGITSVREKMGDKIIGVSAHTIEEARFAIENGADYLGVGPIFPTSTKKDTKAVQGTKGLAYFREQGITVPIVGIGGITIENTAAVIEAGADGVSVISAISLAESAYESTRKLAEEVKRSL
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: U6C_CONCL
Sequence: GCWICWGPNACCRGSVCHDYCPS
What are the official names of this protein?
Conotoxin Cl6c, Cal6.4d.
What are the subcellular locations of this protein?
Secreted.
Protein: HLDE_ECOLU
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKTPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: LYSB_DICDI
Sequence: MRISFFLLILAVIIGYAYGYSCPKPCYGNMCCSTSPGNKYYLTDFCGSTSACGPVPSCSGALYFTADSQRFGCGKHLNLCRGSKCVKAQIYDAGPAMWVEQDAGMMIIDASPTICHVLTGGSSCGWSDKFEITATVTSLTDSRPLGPFNVTEEEKAQLFIDHEIAMAQCEAEKTCNGFDLE
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Lysozyme B, 1,4-beta-N-acetylmuramidase B.
What is the protein family that this protein belongs to?
Belongs to the dictyostelium lysozyme family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle lumen.
Protein: APH1_CAEEL
Sequence: MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLNSRGFHVLVFAVQFLILLICIAYCNVIMGGTISSFVNGIGQSITDAVTLKQVRTLIEERKLRTQRQSVPDEPMTERAGTSNTVNA
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1).  It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.  Required for the localization of aph-2.
What are the official names of this protein?
Gamma-secretase subunit aph-1, Anterior-pharynx-defective protein 1, Presenilin enhancer protein 1.
What is the protein family that this protein belongs to?
Belongs to the APH-1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UREE_ECO5E
Sequence: MLYLTRRVETPAQTTASVTLPVDMRVKSRIKVTLNDGRQAGLLLPRGLLLRDGDILSNENGDEFIKVIAADEAVSVVRCADPFMLAKACWHLGNRHVPLQIMPGELRYHHDHVLDDMLRQFGLDVDFAHLPFEPEAGAYASKSHAHNHDQEHSH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_DECAR
Sequence: MADLDNSQDWLEALKWDADGMIPAIAQDENGRVVMFAYMNRDSLQETVLCGNAVYWSRSRKRLWRKGEESGHFQKVNSIRTDCDGDVLLLSIEQVGGIACHTGRESCFFNELNGDRWIPADPVLKDPKEIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSP2_BOMMO
Sequence: MKSVLILAGLVAVALSSAVPKPSTIKSKNVDAVFVEKQKKILSFFQDVSQLNTDDEYYKIGKDYDIEMNMDNYTNKKAVEEFLKMYRTGFMPKNLEFSVFYDKMRDEAIALLDLFYYAKDFETFYKSACFARVHLNQGQFLYAFYIAVIQRPDCHGFVVPAPYEVYPKMFMNMEVLQKIYVTKMQHGLINPEAAAKYGIHKENDYFVYKANYSNAVLYNNEEQRLTYFTEDIGMNAYYYYFHSHLPFWWTSEKYGALKERRGEVYFYFYQQLLARYYFERLTNGLGKIPEFSWYSPIKTGYYPLMLTKFTPFAQRPDYYNLHTEENYERVRFLDTYEKTFVQFLQKDHFEAFGQKIDFHDPKAINFVGNYWQDNADLYGEEVTKDYQRSYEVFARRVLGAAPMPFDKYTFMPSAMDFYQTSLRDPAFYQLYNRIVEYIVEFKQYLKPYTQDKLYFDGVKITDVKVDKLTTFFENFEFDASNSVYFSKEEIKNNHVHELRCATRLNHSPFNVNIEVDSNVASDAVVKMLLAPKYDDNGIPLTLEDNWMKFFELDWFTTKLTAGQNKIIRNSNEFVIFKEDSVPMTEIMKMLDEGKVPFDMSEEFCYMPKRLMLPRGTEGGFPFQLFVFVYPFDNKGKDLAPFESFVLDNNLLASLWIAPLLMHYSRFLTCISRIFSFTTRVNGSLTNSIFLRMTHMIMLFQKIKF
What is the function of this protein?
Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
What are the official names of this protein?
Sex-specific storage-protein 2, SP 2, Arylphorin.
What is the protein family that this protein belongs to?
Belongs to the hemocyanin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: GP168_BPPH2
Sequence: MIDIIVKEDKRLITVQTPEGDEVFYTLSFSDGHKILKRSSARLRNNIYAIGVANIRWMLVDMDNMILSEYIHHVDILKDIDRKMREMGYIVISEWQHANKKGTRR
What are the official names of this protein?
Gene product 16.8, gp16.8, Protein p16.8.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.8 family.
Protein: CYF_PORPU
Sequence: MKLNSLINLIQKSIYSCTLLLTILNIICIAPNSSNAFPIYAQQAYESPREATGRIVCANCHLAQKPVEIEAPQAVLPNTVFETVVKIPYDNNAKQILGNGSKGGLNVGAVVILPEGFKLAPANRLSPELKEKTKNLYIQPYSTKQSNILVIGPIPGDKNREIIFPILSPDPAKDKQAHFFKYPIYVGGNRGRGQIYPTGDKSNNNLISASASGKINKIEALEKGGFIVHITSTKDSEVNQSIPAGVELKVREGETIQLDQAISKDPNVGGFGQNETEIVLQSPNRIKGMIAFFFVSVLAQIFFVLKKKQFEKVQAAEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS15_STRP4
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIKQHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CLPP1_DESHY
Sequence: MSQLVPMVIEQTSRGERSCDIFSRLLNDRVVMLNGMVTNESASLIIAQMLFLESADCDKDIHFYINSPGGSVTDGLAIMDTMNYIKCDVSTISIGQSGSAASLLLAAGAKGKRFALANSEVLIHQPSISGGLQGQTTDIKIHSDWLTKTKEKLNETYSRLTGQPLEKIQKDMERDYYMTAGQAQDYGLIDKIL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_STRA3
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGQVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQSDMAIAAEHLLKTRHTLEKILADNSGQSIEKVHDDAERDRWMSAQETLDYGFIDAIMENNNLQ
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMXL6_ARATH
Sequence: MPTPVTTARECLTEEAARALDDAVVVARRRSHAQTTSLHAVSALLAMPSSILREVCVSRAARSVPYSSRLQFRALELCVGVSLDRLPSSKSPATEEDPPVSNSLMAAIKRSQANQRRHPESYHLQQIHASNNGGGGCQTTVLKVELKYFILSILDDPIVNRVFGEAGFRSSEIKLDVLHPPVTQLSSRFSRGRCPPLFLCNLPNSDPNREFPFSGSSGFDENSRRIGEVLGRKDKKNPLLIGNCANEALKTFTDSINSGKLGFLQMDISGLSLISIEKEISEILADGSKNEEEIRMKVDDLGRTVEQSGSKSGIVLNLGELKVLTSEANAALEILVSKLSDLLKHESKQLSFIGCVSSNETYTKLIDRFPTIEKDWDLHVLPITASTKPSTQGVYPKSSLMGSFVPFGGFFSSTSNFRVPLSSTVNQTLSRCHLCNEKYLQEVAAVLKAGSSLSLADKCSEKLAPWLRAIETKEDKGITGSSKALDDANTSASQTAALQKKWDNICQSIHHTPAFPKLGFQSVSPQFPVQTEKSVRTPTSYLETPKLLNPPISKPKPMEDLTASVTNRTVSLPLSCVTTDFGLGVIYASKNQESKTTREKPMLVTLNSSLEHTYQKDFKSLREILSRKVAWQTEAVNAISQIICGCKTDSTRRNQASGIWLALLGPDKVGKKKVAMTLSEVFFGGKVNYICVDFGAEHCSLDDKFRGKTVVDYVTGELSRKPHSVVLLENVEKAEFPDQMRLSEAVSTGKIRDLHGRVISMKNVIVVVTSGIAKDNATDHVIKPVKFPEEQVLSARSWKLQIKLGDATKFGVNKRKYELETAQRAVKVQRSYLDLNLPVNETEFSPDHEAEDRDAWFDEFIEKVDGKVTFKPVDFDELAKNIQEKIGSHFERCFGSETHLELDKEVILQILAASWSSLSSGEEEGRTIVDQWMQTVLARSFAEAKQKYGSNPMLGVKLVASSSGLASGVELPAKVDVIW
What is the function of this protein?
Probable component of a transcriptional corepressor complex involved in branching control.  Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation.  Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds (PubMed:26546447, PubMed:26546446).
What are the official names of this protein?
Protein SMAX1-LIKE 6, AtSMXL6, Protein D53-like 2, AtD53-like 2, Protein D53-like SMXL 6.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NLTP_PINTA
Sequence: MAVKKMVEAVFVVGLVVTMMNVWGAVPVEGAISCNQVVSAMTPCATYLIGNAATPAATCCPSIRGLDSQVKATPDRQAVCNCLKTQAKSYGVKLGKAANLPGLCKVTDLNVPISPNVDCSKVH
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein, LTP.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: YCGL_ECOLI
Sequence: MPKPGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKQALTEQGYYLQLPPPPEDLLKQHLSVMGQKTDDTNK
What are the official names of this protein?
Protein YcgL.
Protein: M2_I82A9
Sequence: MSLLTEVETPIRNEWGCRCNDSSDSLVVAASIIGILHLILWILDRLFFKCIYRFFKHGLKRGPSTEGVPESMREEYRKEQQNAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: MP2K4_HUMAN
Sequence: MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.  MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif.  MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue.  The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs.  MAP2K4 is required for maintaining peripheral lymphoid homeostasis.  The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.  Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MURG_SHEDO
Sequence: MTVNPMAPRILIMAGGTGGHVFPALAVAKNLAEKGWQVRWLGTADRMEARLVPQHGFDIDFIDIQGVRGNGLLRTLAAPFKIMRSIMQAREVIAEFKPQVILGMGGFASGPGGVAGRLAGIPLVLHEQNAIPGMTNKLLARIATKVLCAFPNTFALAGQSVQVVGNPVREELALLGSMKQQGQHDALKVLVVGGSLGAKVLNEVMPNVVAQLSRSLSITVWHQVGKNNLASTKACYQQMGQAVNVNVAEFIDDMEAAYRWADVVVCRSGALTVSELAAVGLPSILVPYPHAVDDHQTVNAAILVDAGAGFLLPQAILTSDNLAEKLSLFANNPEVLVQMGKQAREVAVLDATNKVAEICAELARKS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COX1_CHOOC
Sequence: MMRKWLYSTNHKDIGTLYFMFGIWAGMVGTSLSLLIRAELGNPGSLIGDDQIYNTIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSIMLLISSSIVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSILGAVNFITTIINMRPNNMSLDQMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGCLGMIYAMMAIGLLGFVVWAHHMFTVGMDIDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQINYSPSMLWSLGFVFLFTVGGLTGVILANSSIDVTLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWYPLFTGLALNPYLLKIQFFTMFIGVNLTFFPQHFLGLAGMPRRYSDYPDTYTSWNIISSLGSYISLVATMLMLMIIWESLINKRIILFPLNMNSSIEWYQNLPPAEHSYNELPILSNF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COXX_BACC1
Sequence: MNHATSELHDESAVTSVPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVMDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.