PharMolix/UniProtQA huggingface dataset:
Protein: DNAK_BARBK
Sequence: MAKVIGIDLGTTNSCVAVMDGKNAKVIENSEGARTTPSVVAFTDSGERLVGQPAKRQAVTNPEGTVFAVKRLIGRRFDDPMVEKDKALVPYKIVKGDNGDAWVEENSKKYSPSQISAMILQKMKETAESYLGEKVEQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKDGKTIAVYDLGGGTFDISVLEIGDGVFEVKSTNGDTFLGGEDFDMCLVSYFADEFKKEQGIDLKNDKLALQRLKEAAEKAKIELSSSQQTEVNLPFITADQSGPKHLTMKLTRAKFESLVDDLVQRTIEPCKAALKDAGLRAGEIDEVVLVGGMTRMPKIQEVVQNFFGKDPHKGVNPDEVVAMGAAIQGGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTKKSQTFSTADDNQNAVTIRVFQGEREMANDNKLLAQFDLVGIPPAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEHQIRIQASGGLSDADIENMVKDAESHAAEDKKRRENVEAKNQAEALIHSTEKSLTEYGDKVSAEDKGQIEAAIADLKAVLDGDNSEEVKAKMQKLAEVSMKLGQAMYEASNASAEADAVADSANDDVVDADFEEINDKKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CPRA_DESHD
Sequence: MENNQKRQQSGMSRRSFLKVGAAATTMGVIGAIKAPAKVANAAETLNYVPGSGKIRSKLRPVHDFAGAKVRFVENNDQWLGTTKILTKVKMTSEADAGFMQAVRGLYGPEPQKGFFQFIAKDPFGGSISWARNLIAPEDVVDGAPEATKTPIPDPEQMSQHIRDCCYFLRADEVGIGKMPEYGYYTHHVADTVGLMTKPVEECVTPVTKIYPNVIVVMIDQGIETMWASTGYDGISGAMSMKSYFTSGCIAVILAKYIRTLGYNARAHHAKNYEAIMPVCIMAAGLGELSRTGDSAIHPRLGFRHKVAAVTTDLPLAPDQPLDFGLLDFCRVCKKCADNCPNEAISFDEDPIEYNGYLRWNSDFRKCTEFRTTNEEGSSCGTCMKVCPWNSKEDSWFHKAGVWVGSKGETASTFLKSIDDIFGYGTETIEKYKWWLEWPEKYVMK
What is the function of this protein?
Catalyzes the reductive dechlorination of C1-OHPA to 4-hydroxyphenylacetate with reduced methyl viologen as the electron donor.
What are the official names of this protein?
3-chloro-4-hydroxyphenylacetate reductive dehalogenase, C1-OHPA dehalogenase, O-chlorophenol reductive dehalogenase.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUSB_CHLTB
Sequence: MSVMASDKACAPVRASRPFPKQKLRELVLQALYALEIDPEGEDSLVSLLMTEASVSKKNAAYALMFCRAIRANQPDLDALLDATIRTTTLARLTIIERNILRMMLFEHQQNQDCCPVPVAVLIAETTRLIKKFSYSEGSSLILAVLGSIFDHPAPALDTPLEPTSMCG
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: ATPA_RICAH
Sequence: MKLKPIEVAEILQKEIANINCLSEIKEVGQVISVGDGIAKIYGLANVKSGEVVEFKSGVKGLVLNLENDSVSAVIMGDDNQVQQGDNVKRTKEVLEVPVGKALLGRVVDALGNPIDGKGDIASKEYRHIAMKAPGIIERTSVSEPVQTGIKAIDSLIPIGRGQRELIIGDRQTGKTAIAVDTIINQKQAHSLTNESDKIYCIYVAIGQKRSSVAQIVKKLEDAGAMDYTIVVSATASEAASLQFIAPYSACSMGEYFRDNGMHALIIYDDLSKHAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAKMSEEKGNGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFYKGVRPAVNVGISVSRVGSAAQIKAMKQVAGSVKLELAQFRELESFSQFGSDLDPATKAQIDHGKRLVEILKQAQYRPLPVEEQIISLYVGTKKYLNDVPLQKVKEFEDKMLTEIRLNKKDILESIKNEQRITEETEQKLKAFLENFVKAYCVMP
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PCP_THEON
Sequence: MKVLITGFEPFGGEEINPSWEAVRRLPDEIAGAELIKRQLPVTFRGVRELLPRLIVETKPDLVILTGQAGGRPNITVERVAINVMDSTMPDNEGYTPEDEPIFEGAPDAYFATLPIKAIVKALREAKIPAAVSNTAGTYVCNTAMYTVLHTIAVAGMETKAGFIHVPFIHEQALDKPRPSMALETVVKAYEVIIKTSLKA
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHL_ARATH
Sequence: MILLSSSISLSRPVSSQSFSPPAATSTRRSHSSVTVKCCCSSRRLLKNPELKCSLENLFEIQALRKCFVSGFAAILLLSQAGQGIALDLSSGYQNICQLGSAAAVGENKLTLPSDGDSESMMMMMMRGMTAKNFDPVRYSGRWFEVASLKRGFAGQGQEDCHCTQGVYTFDMKESAIRVDTFCVHGSPDGYITGIRGKVQCVGAEDLEKSETDLEKQEMIKEKCFLRFPTIPFIPKLPYDVIATDYDNYALVSGAKDKGFVQVYSRTPNPGPEFIAKYKNYLAQFGYDPEKIKDTPQDCEVTDAELAAMMSMPGMEQTLTNQFPDLGLRKSVQFDPFTSVFETLKKLVPLYFK
What is the function of this protein?
Lipocalin that prevents thylakoidal membrane lipids peroxidation and confers protection against oxidative stress, especially mediated by singlet oxygen in response to high light and other stress (e. g.  heat shocks) (PubMed:19674405, PubMed:23837879).  Required for seed longevity by insuring polyunsaturated lipids integrity (PubMed:23837879).
What are the official names of this protein?
Chloroplastic lipocalin, AtCHL.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: ATPE_ALKMQ
Sequence: MASKFRLQIVTPDRTFLDEEVEMAVVRTVSGDEGILSDHMLMVTPLKIGKMKIQIGDELKEATIAGGFIQVDQDKTIIITDAAEWPEEIDVSRAEEAKQRAEERLQKEREEVDTFRAEIALKKATNRLGLTKNK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RSMC_PSEA8
Sequence: MDPRSEVLLRQRHLFATPLLLAGLPADDLLAELPQAQGWSWHAGEQAQLDARFPGRSRFDTRAPTGAWTSAVLFLPKSRELTDYLLASLAARLPGGELFLVGEKRGGIERASKQLAAYGKPRKLDSARHCQLWQVRIEQAPAEPDLHALAQRYSLPLADGELQVVSLPGVFSHGRLDRGSALLLGQLQALPGGHLLDFGCGAGVLGAALKRRYPASRLTLLDVDAFAVESSRLTLAANGLDGEVIAADGIDGAPRELAAIVSNPPFHQGVHTDYQASERLLQRAAEHLAPGGELRLVANSFLKYPPLIERHLGPCRTLAEGDGFRIYSARRS
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORR_AERS4
Sequence: MISTDSLARIALDLQLGISHQDRFHRLIQSVRSLLHSDASALLRYEGGQFIPLAIDGLMQDVLGRRFALADHPRMEAIARAGDVVRFPADSNLPDPYDGLIPDHDDFRVHACVGLPLFSDQTLIGALTIDGMNPTQFDGISDEELRLVGALAAAALSNALLLERLARQSSEPLAPSTQNGPGRAEMIGRSPAMDRLRHEINVVASSELNVLILGETGVGKELIAKAVHQGSPRASAPLVYLNCAALPESVAESELFGHVKGAFTGAIHNRAGKFELADKGTLFLDEIGELSLSLQAKLLRVLQYGDLQRIGDDTPLKVNVRILAATNRDLKQAVVEGQFRSDLYHRLSVFPIHAPALRERPDDIPLLAGYFCERCRVSLGLERLRIEPRALQLLGSYDWPGNVRELEHAIHRAAVLARAEQGSQAPALECHHFNLAAAGAPSSSRIPVEQVAQQMTAGMGLRTATDAFQLQLIEQTLAAQHGNWAATARALEMDGGNLHRLARRLGLKP
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: PGLR1_SCLSC
Sequence: MVHILSSALSLLRLGAAVSAAPAPAPTAAPNVADALAAVEKRAGSCTFSDPAVPLPAIKSKASCATIVISAVAVPSGTTLDLTGLKSGTHVVFEGTTTFGYEEWSGPLVSVSGTDITVTGASGSVLDGNGAKYWDGKGTNGGKTKPKFFYAHSLKGKSSINNVKILNSPVQVFSINSASGLTLSGITIDNSAGNSLGHNTDAFDVGSSTDITISGANVQNQDDCLAINSGTGITFTGGTCSGGHGLSIGSVGGRSDNVVSDVIIESSTVKNSANGVRIKTVLGATGSVSGVTYKDITLSGITSYGVVIEQDYENGSPTGKPTSGVPITGVTLSNVHGTVSSSATNVYVLCAKCSGWTWDVNVTGGKTSTKCAGLPSGVKC
What are the official names of this protein?
Endo-polygalacturonase, PG, Pectinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAG15_HUMAN
Sequence: MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP
What is the function of this protein?
Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495).  Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495).  Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:29724779).  Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity).  Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:29724779).  Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:30830753).  Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity).  At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (PubMed:10092508).
What are the official names of this protein?
Phospholipase A2 group XV, 1-O-acylceramide synthase, ACS, LCAT-like lysophospholipase, LLPL, Lysophospholipase 3, Lysosomal phospholipase A and acyltransferase, Lysosomal phospholipase A2, LPLA2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Membrane; Peripheral membrane protein.
Protein: PRMA_GEOMG
Sequence: MDKTWAEVTCEIPAAMIDLLADFLVELSGNGVSIDNLELDTFSLDTMDEAPVKTVRAYFTPDDELEEKLAALNRFIQEHAPAYGDAAPAPPTVTTLREEDWATGWRQHFAPTRIGRKLVIKPTWEPFSPEPGDLVIELDPGMAFGTGTHPTTRLCLEALEKLGTAGDVLDVGTGSGILAMAAVKLGAQRVVGTDIDPDAVAVARENCAMNGVTAELVTTPLADIPGQFSVVLANILAEDLVRMAADLTAKVAPGGFLILSGILVERESYVIDGFVSTGLTLAETTREGEWSCLLYQAGQ
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_BARQU
Sequence: MDIILLERIPRLGQMGDIVSVKDGYARNFLLPQGKALRANDANKKHFEKQRAQLKARNLERKSEAQKIAEKLDGKSFIVVRSAGETGQLYGSVSTRDISEIITSAGFSIGRNQIELNHPIKTIGLYLITLSLHPEVQISVVINVARSASEAQRQAEGETLTSAEAIYDIQEKPLAENQEEMNDNDANSINEQA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RK21_NEOYE
Sequence: MTYAIIEASGTQLWIEEGRYYDLNHIPVDPGQSIILGKVLLLNKNGEVTLGRPCIEGVTIKATVMRHLRGKKITVFKMKPKKKMRLKKGHRQELTRLMIDSITS
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VPS54_CAEEL
Sequence: MKSMDDRTVGLISASSSRASLKIQPEIGYPRICDYCQPIIELMTASEFARHIRQDHTTKEGGSFLCRYGEHGVCQKLPLEGVCDLDFEAHIRRCHTSSQPAGYSSPTSSLVASYTEDSEETASLRSIRLTSDRDTPTIEKKKFTLHSFTQNLSAVLADPSRSRSDLTTFFTRHWGDSFVPTQPVPQSKRLARLADSAFDSYCQSAGESYRRYQAIKRALRLSHADGGVGIGDERQDAEDLPTIFIDPRFTLGDSSTFSDVFTVPANDDLDALKQTLSGRNVIPATPLEIATNRKPGEFRDYEALQNRLEMMHDVVDGRLAGKLVAKTDDFWQVVRSYSGLQEQLANALQCVMVVRKNLKRVDELVCDQSKKIVEVHERYEQKKKLLAKLHDISCLREAQSTVQMMLSQGDYPKAIECIETSLDVLSKELNGVTCFRHLASQLRELYTVIGRMMNEDFASLIQKELGVKPEAGTMIQAEGELSAVLLGLMRMRKYSFIAVLREEIIEGVKSVMRQVIKNQILNNGVDLNDFDPSLTQLGEPVRRMKHADFLKTVKAVMDEEFYFCKRLEALQDILLETVERANPLHRHGSEDIIVERIEEAKDIHESESDDEVGTTFSKSASSGGFSVGGSALSSNASATTLLSIEVRSEAFLRHVLPLIAEFGHQCAQQRISRLLIARAKNASVTEATTPTQLSECIKLVKEFQSKCDKEGWYSTQNQKVGGLGRSVNKLSMDYIEKFHAARKIRIGNMLDTELWKATDVSIVDQNIVDMAMETGQLRNTKRIDDGPIKKSFKRTESAVTIDSTTSTSNQIQGVIVDEENYVVVGSSITMIQLLSDYCEAISEMPSFSQDWNSRVVELLKTFNSRCCQLILGAGALQLVGLKTISVRNLALAGRSLELVCRFIPMVHDEMDRVLPENRKSLLRYFKQVESEYRDHVNEIAAKLISVIAHYTTNCLGMWDVKGVIPSPEFQQICRHMLKFHNGLVGIMPRDQIEALFRQVHENFKANLREHVTGMGITPHDPLKYGYVTKDYMFYQQNVKNMESCRNLELESLNDIMFE
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 54.
What is the protein family that this protein belongs to?
Belongs to the VPS54 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: MINE_POLNA
Sequence: MASFFSFLLGEKKKTANVAKERLQIILAHERSGRNSHEPDYLPALQRDLIAVIAKYININPNDIKLNLERQENLDVLEVKIELPDK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: IHFB_SALCH
Sequence: MTKSELIERLATQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: UBC_PANTR
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin-C.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: NU100_YEAST
Sequence: MFGNNRPMFGGSNLSFGSNTSSFGGQQSQQPNSLFGNSNNNNNSTSNNAQSGFGGFTSAAGSNSNSLFGNNNTQNNGAFGQSMGATQNSPFGSLNSSNASNGNTFGGSSSMGSFGGNTNNAFNNNSNSTNSPFGFNKPNTGGTLFGSQNNNSAGTSSLFGGQSTSTTGTFGNTGSSFGTGLNGNGSNIFGAGNNSQSNTTGSLFGNQQSSAFGTNNQQGSLFGQQSQNTNNAFGNQNQLGGSSFGSKPVGSGSLFGQSNNTLGNTTNNRNGLFGQMNSSNQGSSNSGLFGQNSMNSSTQGVFGQNNNQMQINGNNNNSLFGKANTFSNSASGGLFGQNNQQQGSGLFGQNSQTSGSSGLFGQNNQKQPNTFTQSNTGIGLFGQNNNQQQQSTGLFGAKPAGTTGSLFGGNSSTQPNSLFGTTNVPTSNTQSQQGNSLFGATKLTNMPFGGNPTANQSGSGNSLFGTKPASTTGSLFGNNTASTTVPSTNGLFGNNANNSTSTTNTGLFGAKPDSQSKPALGGGLFGNSNSNSSTIGQNKPVFGGTTQNTGLFGATGTNSSAVGSTGKLFGQNNNTLNVGTQNVPPVNNTTQNALLGTTAVPSLQQAPVTNEQLFSKISIPNSITNPVKATTSKVNADMKRNSSLTSAYRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPESSYLNSNDLLFDPDRRYLKHLVIKNNKNLNVINHNDDEASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIPMIENEKISSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNITHPLLKRSIAKLKENPVYKFESYDPVTGTYSYTIDHPVLT
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).  NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport.
What are the official names of this protein?
Nucleoporin NUP100/NSP100, Nuclear pore protein NUP100/NSP100.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin GLFG family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
Protein: GLNB_ECO57
Sequence: MKKIDAIIKPFKLDDVREALAEVGITGMTVTEVKGFGRQKGHTELYRGAEYMVDFLPKVKIEIVVPDDIVDTCVDTIIRTAQTGKIGDGKIFVFDVARVIRIRTGEEDDAAI
What is the function of this protein?
P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA.  When P-II is uridylylated to P-II-UMP, these events are reversed.  When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II 1.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: TM140_HUMAN
Sequence: MAGPRPRWRDQLLFMSIIVLVIVVICLMFYALLWEAGNLTDLPNLRIGFYNFCLWNEDTSTLQCHQFPELEALGVPRVGLGLARLGVYGSLVLTLFAPQPLLLAQCNSDERAWRLAVGFLAVSSVLLAGGLGLFLSYVWKWVRLSLPGPGFLALGSAQALLILLLIAMAVFPLRAERAESKLESC
What are the official names of this protein?
Transmembrane protein 140.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PF12_PIG
Sequence: METQRASLCLGRWSLWLLLLALVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRRPPELCDFKENGRVKQCVGTVTLDQIKDPLDITCNEGVRRFPWWWPFLRRPRLRRQAFPPPNVPGPRFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFPGRR
What is the function of this protein?
Exerts antimicrobial activity.  It is more effective against Gram-negative bacteria than Gram-positive bacteria.
What are the official names of this protein?
Prophenin-2, C12, PF-2, PR-2, Prophenin-1-like.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPC_SYNE7
Sequence: MEVRRRPPNPAVHVASLTYQVKVPGSSPSNILEEIVWYKEREVNAWREQLPLQQLQNQVRGLTQTPRDFLAALRQAPTRPAVIAEVKKASPSKGVLREDFDPVAIAQAYAANGAACISVLTDEKFFQGGFENLQRVRAAVDVPLLCKDFVIYPYQIYKARLLGADAVLLIAAILSDADLRYFLKIAHSLGLNALVEVHSLPELERVLALDDLRLVGINNRNLKTFVTDLAVTEHLAAQCRDRDLLLVSESGLFTGADLDRVTQAGAQAVLIGESLVKQPDPGLALQQLVGDRPSA
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: NCAP_MOPEI
Sequence: MSNSKEVKSFLWTQSLRRELSGYCSNIKIQVIKDAQALLHGLDFSEVANVQRLMRKEKRDDSDLKRLRDLNQAVNNLVELKSVQQKNVLRVGTLTSDDLLVLAADLDRLKAKVIRGERPLAAGVYMGNLTAQQLEQRRVLLQMVGMGGGFRAGNTLGDGIVRVWDVRNPELLNNQFGTMPSLTIACMCKQGQADLNDVIQSLSDLGLVYTAKYPNMSDLDKLSQTHPILGIIEPKKSAINISGYNFSLSAAVKAGACLIDGGNMLETIKVTKSNLEGILKAALKVKRSLGMFVSDTPGERNPYENLLYKLCLSGEGWPYIASRTSIVGRAWDNTTVDLSGDVQQNAKPDKGNSNRLAQAQGMPAGLTYSQTMELKDSMLQLDPNAKTWIDIEGRPEDPVEIAIYQPNNGQYIHFYREPTDIKQFKQDSKHSHGIDIQDLFSVQPGLTSAVIESLPKNMVLSCQGADDIRKLLDSQNRRDIKLIDVSMQKDDARKFEDKIWDEYKHLCRMHTGIVTQKKKRGGKEEVTPHCALLDCLMFEAAVIGSPQIPTPRPVLSRDLVFRTGPPRVVL
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC).  Serves as template for viral transcription and replication.  The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses.  Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation.  Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.