PharMolix/UniProtQA huggingface dataset:
Protein: NUOB_RUEPO
Sequence: MAVMTGANTAGVDKEVATQALNAELQDKGFLLTSTEDIINWARTGSLHWMTFGLACCAVEMMHTSMPRYDAERFGIAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGLLQLQRKIRRTGTIVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TM41A_HUMAN
Sequence: MRPLLGLLLVFAGCTFALYLLSTRLPRGRRLGSTEEAGGRSLWFPSDLAELRELSEVLREYRKEHQAYVFLLFCGAYLYKQGFAIPGSSFLNVLAGALFGPWLGLLLCCVLTSVGATCCYLLSSIFGKQLVVSYFPDKVALLQRKVEENRNSLFFFLLFLRLFPMTPNWFLNLSAPILNIPIVQFFFSVLIGLIPYNFICVQTGSILSTLTSLDALFSWDTVFKLLAIAMVALIPGTLIKKFSQKHLQLNETSTANHIHSRKDT
What are the official names of this protein?
Transmembrane protein 41A.
What is the protein family that this protein belongs to?
Belongs to the TMEM41 family.
Protein: PCGF1_XENTR
Sequence: MASQGPLVIAMRLRNQLQSVYKMDPLRNEEVVKVKIKELNEHIVCYLCAGYFIDATTITECLHTFCKSCIVKYLQTSKYCPLCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQENEDGRIRDFYHSRGLERVLQPSAVEDSVGDVSQLSLSLAVSQKTSHYYRNDEHVCLCLEKVSSGKDKKKFILEQKYVRCSVRSEIRHLRRVLSHRLSAPLAHVQLLIDNKVLPDHMTMKQLWLTHWYGKPAPLVLLYSVREKRR
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
What are the official names of this protein?
Polycomb group RING finger protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: USTF2_ASPFN
Sequence: MANPQTTRVAVVGAGISGVLAAGHLLATGLEVTVFERNAAPGGVWYAIPFSGLLATREADAWARLYDERTPIEPSYPAMKPSKADPPATNEQETSRFMLQHAPPGPCYYNLQNNVPTPLLEVSLKPWPDGTPDTVRHDVIQRFIQDMSIEAKVHDVTRYEARVKKVVKDGAEWKITWSTPQVGLQSETSEFEQVSPFDVVIVASGHYHAPRVPDIPGLSDTKRKYGSRILHSKEYRRPENFRNKNILMIGGGVSSIDIANDISPFANTIYQSTRNSKFDLVESMLPENGVRVHEISHFEIQSHSDEPLSDDEPLPLTIHFESGQNLHGIHMIMLCTGYHITFPYLEEYHSDETTLQDADENILITDGTQVHNLYQDIFYIPDPTLVFVGLPYYTFTFSIFDFQAIVVAQVLSGTVQLPTETEMRSEYNAKVERVGLGKVFHSILGTEENYVHDLLTWVNTSRAAQELVAIKGFSPRWYEAKEALRQKYRAQVNK
What is the function of this protein?
Flavin-containing monooxygenase; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide (PubMed:24841822, PubMed:27166860, PubMed:26703898).  First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-terminal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) (PubMed:24841822).  Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI (PubMed:24841822).  To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline (PubMed:24841822).  One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH (PubMed:24841822).  Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F (PubMed:27166860, PubMed:26703898).  For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization (PubMed:27166860).  UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations (PubMed:27166860).  N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H (PubMed:27166860).  The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H (PubMed:27166860).  Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B (PubMed:27166860).
What are the official names of this protein?
Flavin-containing monooxygenase ustF2, Ustiloxin B biosynthesis protein F2.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
Protein: HBB_CALGO
Sequence: MVHLTGEEKSAVTTLWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMNNPKVKAHGKKVLGAFSDGLTHLDNLKGTFAQLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPTVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DAPB_SALTI
Sequence: MHEAQIRVAIAGAGGRMGRQLIQAAMAMEGVQLGAALEREGSSLLGSDAGELAGAGKSGVIVQSSLEAVKDDFDVFIDFTRPEGTLTHLAFCRQHGKGMVIGTTGFDDAGKQAIREASQEIAIVFAANFSVGVNVMLKLLEKAAKVMGDYSDIEIIEAHHRHKVDAPSGTALAMGEAIAGALDKDLKDCAVYSREGYTGERVPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGALRSALWLKTKKNGLFDMRDVLGLDVL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_CHLT2
Sequence: MKQQKQRIRIRLKGFDQGQLDQSTANIVETAKRTGARVVGPIPLPTKREVYTVLRSPHVDKKSREQFEIRTHKRLIDILDPTGKTIDALKMLSLPAGVDIKIKAA
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PUR9_SHISS
Sequence: MQQRRPVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEEHQIQPIDMVVVNLYPFAQTVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDDNEGSLTLATRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKQDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFAEPACVIVKHANPCGVAIGNSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASEEALKITAAKQNVRVLTCGQWGERVPGLDFKRVNGGLLVQDRDLGMVGAEELRVVTQRQPTEQELRDALFCWKVAKFVKSNAIVYAKNNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSSMASDAFFPFRDGIDAAAAAGVTCVIQPGGSIRDDEVIAAADEHGIAMLFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: DCL2_CRYPA
Sequence: MAYYTDSSSSESEDFEDVINQVVAEEDITGAAWYDGHLSEEDSPGGKPRPKEQLPKDIVKMDARAYQLEMLEASLKENIICAMDTGSGKTHVAILRIKAELEEMPEGQVVWFLTPTVSLCAQQYAVVKAQIPSVQTKIVTGADKVDSWSSTTWDGALLNVKVIITTPQVLLDALLHGFVNISSLALMVFDEAHHCNKNHAYSRVMKEFYWESKTKHEPVPRILGLTASPVVRSDISSLKRLESTLDAVCRSPTRHREELIANSQRPALFSIIYNPKLQPYAAGFSESLTKLMAARNKLNILEDPYVVSLRAEISDRSRRKLEKAIKEKRTYVQDTMKSFCRRSMEMAKELGAWAADWFISEAIRLFLAGIYRQGASSKSFRDAEVIFLARVFQDANIEPPPPLTTHSGLSEKVQRIIEVLLNYDKDARAICFVKERATTVVLSHILTTHPEVSSKFRIGTMVGTSFVPGVKRDFLDLPETGGSQCLEAFREGRKNMLVATSVLEEGIDVPACNLIICFDKPNNLRAFIQRRGRARMRQSHLYLFVEDEAEADWEALEAQMKLQYEDEKREHERLEAIENSEALDYPEELRVESTGARLTINDAKSHLQHFVSTLASRKFVQTQPDYLIEKVSQGYQPGDQPLLKATVLLPVSVPQALRQVTSSRTWVSEKNACMDAAFQAYKALYEAGLVDDHLLPLRDRLELELEVRPGMREVRGLYNPWLSIAAACTQGDVPLCRRALKVSDGNNSELCEFELAIPVALPEMKPMVVWWDHRAQLTLRIDSDAVMADTDVRHADQTTINQQDHTSVLLSLAYGHRNMTIRDDCILRLVSKSGPLSMEQLGQVEFAPGLVTANGSSYLVRDERDQSRHPYYFESVLPSKPPAESIRKVYRGFDEDPTEATYLSVRKWPKKTGFFHRPCSPQHSPSTKPYAYILPAETTTVDRIPLVYAQMGLLMPSLVCYTELYLVAAELSRKVLAPLRISNVSMLVEAICAKSARTPENYERIEFLGDSILKTCITVNLAATKLHLPEGILSLMKDRLVSNARLCRAACDAELDQFLVTQQLVTKGWQPPYMSDLAKQDQEPESKRILSPKTLADVVEALIGVSFVDGGLPKALECIRLFIPESQPRPFSEVRDILFGAAEPKGMKLPADLQLLEQLIEYSFCEKALLVEAVTHPSYNVSGTVACYDRLEFIGDAILDYIIVEEVFALEPALENWQMHLLRTALVNADILGFLIMEWSYKQMGFEVCRANEGDSDSKSSGDSTSDKASPRLEQTEVPIPLWSFMRQSSAELTMEREITKARFEELRDPILEAMRSGTHYPWALFARLHAQKFYSDFFEALVGAIWVDAGPGFDACRAFVARSGVLPYLKRLLRDQVHVLHPKEELGRLAGRERVEYVVKETLKDDGDGKEWACEVRVGGRYVTDVTGCLFKEESRVKAATQACEILKRK
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense, DCL-2 is involved in antiviral defense against mycoviruses like the hypovirus CHV1-EP713 and the reovirus MyRV1-Cp9B21.
What are the official names of this protein?
Dicer-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: ATPA_SOLM1
Sequence: MQIKAEEISQIIEQQIQHYESRVEMSETGTVLSVGDQIARVYGVQNAMAMELLEFPGGVMGLVLNLEEDNVGVALLGEDTHIKEGDPVKRTGKIFSVPVGDAVTGRVIDPLGNPIDGLGPVEAKETRNVEIKAPGIIARKSVHEPMYTGLKAVDAMTPIGRGQRELIIGDRQTGKTAVCIDAILAQKGQGVFCFYVAIGQKKSTVALVAETLRRHGAMEYTTIISATASEPASLQFMSAYSGCTMAEYHRDNGRAALIIYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDALGAGSLTALPIIETQAGDVSAYIPTNVISITDGQVYLEPNLFNAGIRPAINVGLSVSRVGGAAQVKAMKQVAGTLRLDLAQYRELAAFAQFGSDLDKATQLKLSRGMRMVELLKQPQYKPMNVAEQVISLFAGTRGFMDDVPVEAVRKFEEGLQEYFHNAKSDILNEIQEKKALDEGLIAKLGAAIDEFKKGFKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL15_LACDB
Sequence: MKLNELHPSEGSRHARKRVGRGTSSGFGKTSGRGQKGQHARSGGNTRLGFEGGQMPLFRTMPKRGFKNINRKEYAIVNLADLNKFEEGSVVDFEALKAKGLVKKQLSGVKVLGNGDLNVKLTVKVNKVSEAAKSAIEAAGGTVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ALF_RHIME
Sequence: MARITLRQLLDHAAERSYGVPAFNINNMEQGLAIMEAARASDAPVILQVSRGARSYANDVMLAKMMEALEEMYPDIPLCIHQDHGNNVATCLTAIQHGFTSVMMDGSLKEDAKTPADYDYNVSITAEVSRLAHMVGASVEGELGCLGSLETGHGEAEDGHGFEGALDRSQLLTDPDEAARFVAETGVDALAVAIGTSHGAYKFTRKPTGEVLAMDVIEKIHERLPDTHIVMHGSSSVPQEWQDVFNAHGGQMRETYGVPVEEIVRGIRFGVRKVNIDTDLRLAAAAAFRRVADTSRSEFDPRKFLKPAMDAMSAVCKARFEAFGTAGNASRIKVVPMPEMARRYASGSLKPQSARSEAA
What is the function of this protein?
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
What are the official names of this protein?
Fructose-bisphosphate aldolase, FBP aldolase, FBPA, Fructose-1,6-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family.
Protein: RS13_ACIB5
Sequence: MARIAGVNIPDNKHAVISLTYIFGIGRHTAKNILAAVGITETTKIRELDDAQLDAIRAEVAKVPTEGDLRREISMNIKRLMDLGCYRGLRHRRSLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RS6_SYNR3
Sequence: MSAKPNYETMYILRPDIAEEEVESHANKYRDLVVEAGGEVIDSQMRGKRRLAYNIGKHREGIYIQLNYSGDGKQVGPLEKAMRLSEDVIRYLTVKYEGQHSSLGRSTAPANPMASNTPRTEGQEQAKTEPQTAPA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: NBLIK_BEUC1
Sequence: MTFAIPDDLAPEVYPLAWLLGRWRGPGFLAYPDIPERPVVVETEFTHDGGPYLAYASTTWLLDGELAGLDRPFDPEALAAGQLWAAESGYWRPVVGGPRRSAFGVVQEGSDTRTEPGGAEPDPAGRRAPSTEVEVLLAEPSGHVSVFVGSVRGPRIDLATDLVARTSTAAEVTAATRMYGLVQGDLMWATDLAAFGHEMQSYSSGRLARMA
What are the official names of this protein?
Ferric nitrobindin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RPIA_SYNR3
Sequence: MADLQTQMKQAVALAATDQVKNGMVLGLGSGSTAALMIQEVGARLRDGRLTDIVGVTTSFQGEVLAAELGIPLQSLNAIDRIDLAIDGADEVDPAFELIKGGGACHVQEKLVARRAERFVVVVDSTKLVERLNLGFLLPVEVLAGAWRQVQAELQQLGGSAELRMAQRKAGPVVTDQGNLVLDVSFAGGINDPAGLETTINNIPGVLENGLFVGLADQVLVGEINDGVAGVRDLVKS
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: ACSM1_HUMAN
Sequence: MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM
What is the function of this protein?
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065).  Capable of activating medium-chain fatty acids (e. g.  butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e. g.  benzoate (PubMed:10434065).  Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity).  Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity).
What are the official names of this protein?
Acyl-coenzyme A synthetase ACSM1, mitochondrial, Acyl-CoA synthetase medium-chain family member 1, Benzoate--CoA ligase, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, Lipoate-activating enzyme, Middle-chain acyl-CoA synthetase 1, Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion.
Protein: HNMT_CAVPO
Sequence: MASSMRSLFSDHGRYFEAFRRFLNNSTEYQCMREFMDKQLPGIIARIGGSKSEIKVLSIGGGAGEMDLHILSKVKAQYPGVHIINEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETSSEYQNRVMEQKEIQKWDFIHMIQMLYYVDDIPATLKFFHSLLATNAKILIILVSGKSGWLKFWKKYRSRLPQNDLCQYVTSFDIIQMLDSLGIKYQCYDLLSTMDITDCFIDGNENGELLWDFLTETCNFLTTAPPDLRAEIMKDLQGPEFIVRKEGKILFDNSLSFITIEA
What is the function of this protein?
Inactivates histamine by N-methylation.  Plays an important role in degrading histamine and in regulating the airway response to histamine.
What are the official names of this protein?
Histamine N-methyltransferase, HMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_BORPA
Sequence: MTAQTSAVSVISAANRLVAKVGSSLVTNEGRGLDRAAVDHWAAQIAALHQQGKQVVLVSSGAIAEGMARLGWRKRPSAMHELQAAAAVGQMGLCQAYEAAFAEFGLRTAQILLTHEDLADRHRYLNARSTLFALLRLGVVPIVNENDTVVTDEIRFGDNDTLGALVTNLIEADALIILTDQRGLYEADPRCDPAARFVAHAQAGDAALEAMAGGAGSGVGTGGMLTKILAAKRAAHSGAHTVIASGRERNVLTRLAQGECIGTELRAVLPVWSARKQWLADHLRLRGRVVLDDGAVHALLHEGKSLLPIGVAEVQGEFERGDVVACVDMHGRECARGLINYSSADTRRILRQPSSQIARILGSMTDPELMHRDNLVVT
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIPA_SALCH
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDDDVEEDEGVGEVRVHRVNHAPGQSQEHDAPRQSPQHQYQPPYASAQPRPAAPPQPQAPMQQPVQQPVQPAPQPQQVQPSAPPVQPPQQQPAPPSQAPQPVAQPAPPPSAQTFQPAEPVVEAEPIVEEAPVVEKPQRKEAVIIMNVAAHHGSELNGEVLLNSIQQSGFKFGDMNIFHRHLSPDGSGPALFSLANMVNPGTFDPEMTDFTTPGVTIFMQVPSYGDALQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDRIREVMDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: MDM12_ASPCL
Sequence: MSIDINWRTATSGPDGEALAERIRSFIHDRFQQVALPRFIRSVQVHSFDFGTIPPELEIKDFCEPFADFYEEDDDADTSDVSEDLLSEHSSQWDRTHSELNEPPYREESAMNHGLRDPFHEGFPPSPLRSPLGEHLNPHFLPRAGTPGIPGGTSNLGYHLMSLGGLSGTQTPLAAVAGGNPFASGWSDSGMGFGNRGRSERQGPIPQHRPEPEIDTSNSTSRPSTANTLPSHLSESNNLNADGATGRNERGSLHNGDPLADHTCSGHLPLPPRMRERRPEDFQVLCHAKYAGDVRLSLTAEILLDYPMPSFVGLPLKLNVTGITFDGVAVVAYIRKRVHFCFLSAEDADALIGSEQQQESGGDDHRPRSGADSSAHTSQKRQGGLLQEIRVESEIGRKENGKQVLKNVGKVERFVLAQVRRIFEEELVYPSFWTFLI
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.  The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: ZNG1A_HUMAN
Sequence: MLPAVGSADEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them.  Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation.  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1.  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis.  GTP/GDP exchange is required for release of active METAP1.
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1A, Cobalamin synthase W domain-containing protein 1, COBW domain-containing protein 1, NPC-A-6 COBW domain-containing protein 1, NPC-A-6.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: Y316_SHESM
Sequence: MTKKIELAQIQVLFLGIWRFLLHLRQRLVEDQINIRAGHLAYVTLLSLVPMVAVTMSMLSAFPVFKGIRGQIEAFVYENFLPAAGDTVQVYINEFVGNASKGTAVGIAALVVVAIMLISAIDKSLNNIWRTKEKRSVVVAFSMYWMVITLGPVLVGASLVATSYVVSLKLFEGDALSGVMPLFIERLPLFFSVAAFLLLYMVVPNQKVKFWHALLGAVVAALLFELGKKGFALYVTKFPSYEAIYGALATIPILFVWVYLSWMIVLLGAEITAAMPEYLDYESSSDINETNLDGQPLAAQDTPAAQPETTSGQSTQVLETTGELAATAPQSTTLDKP
What are the official names of this protein?
UPF0761 membrane protein Shewmr4_0316.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YVCR_BACSU
Sequence: MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPSGSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTLTIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAIIHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFIKDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YvcR.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: ENGB_LEPBP
Sequence: MHKYSKEIPFPETKFFTSIAKLDEKEDLDSVQSIAFMGRSNSGKSSLLNALSNHRGLAKVSRTPGKTKLINIFRTKVGFNLVDLPGFGYSKASHKEHKDMMNLLEGFLNSWKQLKILFILCDSQRDFPEEELSTIEVAMEKKIKPVVIRTKIDKLNQSGQHKVRTEMEAAMNEIGIPFRVFYISASTGRGIGELREFILETLGIQTKVSNVEP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.