PharMolix/UniProtQA huggingface dataset:
Protein: GLNK_SHIFL
Sequence: MKLVTVIIKPFKLEDVREALSSIGIQGLTVTEVKGFGRQKGHAELYRGAEYSVNFLPKVKIDVAIADDQLDEVIDIVSKAAYTGKIGDGKIFVAELQRVIRIRTGEADEAAL
What is the function of this protein?
Involved in the regulation of nitrogen metabolism.  Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell.  Involved in the regulation of the ammonium transporter AmtB so as to optimize ammonium uptake under all growth conditions.  In nitrogen-limited conditions, GlnK does not interact with AmtB, which remains active and imports ammonium.  When extracellular ammonium increases, GlnK associates tightly with AmtB in the inner membrane, thereby inhibiting the transporter activity.
What are the official names of this protein?
Nitrogen regulatory protein GlnK, Nitrogen regulatory protein P-II 2.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane. Note=During nitrogen limitation, GlnK is predominantly in its fully uridylylated state in the cytoplasmic fraction. In response to nitrogen shock, GlnK is deuridylylated rapidly and associates tightly with AmtB in the inner membrane.
Protein: ISPE_BACSU
Sequence: MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELTELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGGSSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHISTPPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLESVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQVYAVRMIGEQNALD
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: DRS4_AGADC
Sequence: GMWSKIKNAGKAAKAAAKAAGKAALGAVSEAM
What is the function of this protein?
Antimicrobial peptide with activity against Gram-negative bacteria, but not against Gram-positive bacteria (PubMed:19843179).  Active against E. coli (MIC=5 uM), and P. aeruginosa (MIC=40 uM) (PubMed:19843179).  Acts by disrupting cell membranes (PubMed:19843179).  Is able to depolarize membranes of Gram-positive and Gram-negative bacteria (PubMed:19843179).  Also acts as a potent chemoattractant for human leukocytes and activates them mainly through a GPCR, possibly FPRL1 coupled to the ERK1/2 MAPK pathway (PubMed:19843179).  Is unstructured in water but become helical upon binding to anionic lipids (PubMed:19843179).  In contrast to most dermaseptins, is not structured in the presence of zwitterionic lipids (PubMed:19843179).  Does not show hemolytic activity (PubMed:19843179).
What are the official names of this protein?
Dermaseptin-DA4, DRS-DA4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: ASSY_POLAQ
Sequence: MSDIKKAVLAYSGGLDTSVILKWLQDTYGCEIVTFTADLGQGEELEPARAKALQFGIKPENIFIDDLREEFVRDFVFPMFRANTIYEGEYLLGTSIARPLIAKRQIEIARLTGADAVSHGATGKGNDQVRFELGYYALEPGIKVIAPWREWDLLSREKLMAYAEKHGIPVEMKHKQGGSPYSMDANLLHISYEGRHLENPNAEAEESMWRWTVSPEKAPDAPEIIEIEFRAGDPVAIDGKAYKPHELLAELNRIGGKHGIGRLDLVENRFVGMKSRGCYETPGGTILLKAHRGIESITLDREVAHLKDDLMPRYASLIYNGLWWAPERLALQTLIDHTQQAVNGVVRLKLYKGSVSVISRDSANTLFDQNIATFDDDGGAYNQADAGGFIKLNALRMRIAETAKRKRAQK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_VEREI
Sequence: MNLIQTLEAEEIARLNKTIPDFSAGDTVIVNVNVVEGSRKRVQAYEGVVIAKRNRGLNSGFIVRKISSGEGVERTFQTYSPLIASIEVKRRGDVRRAKLYYLRERSGKSARIKEKLPARTKAAAASAA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: CHSD_IPONI
Sequence: MVTVEEVRKAQRAEGPATILAIGTATPANCVDQSTYPDYYFRITNSDHMTDLKQKFQRMCDKSMITKRYMHLTEEILKENPSFCEYMAPSLDARQDIVVVEVPKLGKEAAQSAIKEWGQPKSKITHVIFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKAARVLVVCSEITVVTFRGPNETHLDSLVGQALFGDGAAAIIVGSDPTPAEKPLFQLVSAAQTLAPDSCGAIDGHLREVGLTFHLLKDVPSIVSNNIEKCLSEAFNPLGISDWNSIFWIAHPGGPAILDQVEDKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASSNDGLGTTGEGLEWGVLFGFGPGLTIETVVLHSVPA
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase D, Naringenin-chalcone synthase D, CHS-D.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: VES_ECOHS
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMLLESADRFNHTLKPFQPFAFAADQVVKAKLTAGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: PTU3C_STAA9
Sequence: MFKKLFGQLQRIGKALMLPVAILPAAGILLAFGNAMHNEQLVEIAPWLKNDIIVMISSVMEAAGQVVFDNLPLLFAVGTALGLAGGDGVAALAALVGYLIMNATMGKVLHITIDDIFSYAKGAKELSQAAKEPAHALVLGIPTLQTGVFGGIIMGALAAWCYNKFYNITLPPFLGFFAGKRFVPIVTSVVAIATGVLLSFAWPPIQDGLNSLSNFLLNKNLTLTTFIFGIIERSLIPFGLHHIFYSPFWFEFGSYTNHAGELVRGDQRIWMAQLKDGVPFTAGAFTTGKYPFMMFGLPAAAFAIYKNARPERKKVVGGLMLSAGLTAFLTGITEPLEFSFLFVAPVLYGIHVLLAGTSFLVMHLLGVKIGMTFSGGFIDYILYGLLNWDRSHALLVIPVGIVYAIVYYFLFDFAIRKFKLKTPGREDEETEIRNSSVAKLPFDVLDAMGGKENIKHLDACITRLRVEVVDKSKVDVAGIKALGASGVLEVGNNMQAIFGPKSDQIKHDMAKIMSGEITKPSETTVTEEMSDEPVHVEALGTTDIYAPGVGQIIPLSEVPDQVFAGKMMGDGIGFIPEKGEIVAPFDGTVKTIFPTKHAIGLESESGVEVLIHIGIDTVKLNGEGFESLINVDEKVTQGQPLMKVNLAYLKAHAPSIVTPMIITNLENKELVIEDVQDADPGKLIMTVK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in alpha- and beta-glucoside transport (By similarity).
What are the official names of this protein?
PTS system glucoside-specific EIICBA component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYL_BORHD
Sequence: MSEYNFTKIEKKWQDYWDKHKTYKVNEDPNIPKEKRIYILDMFPYPSANGLHVGHPEGYTATDILTRYKLLNGFNVLHPIGFDSFGLPAENYAIQTGEHPKKITEKNIKKFKEQIKALGFAYDWDREIRTHDENYYKWTQWIFLKLYKKGLAYTKEMPVWYCPDLGTVLSNEEVIQTPDGPRSERGFHKVKRKPLRQWILKITEYAERLIKDLEEIDWPESVKEMQKNWIGKSTGAEIEFSVKASKEKIKVFTTRPDTIFGVTYLVLAPEHSIVDKITKDEFKPMIVEYRERETLKSDLERTSLEKDKTGVFTGAYAINPITGEEIPIWIGSYILGTYGTGAVMSVPAHDARDFEFAKKYNLPIKQVVSQTGNNEILTQPFTENGISINTPEEFNNLKTDEIKERVIKWLTENKKGQKKVNYKLRDWIFSRQRYWGEPIPIILDDDLNEIPLEEDELPLRLPEIENYKPSGTGESPLSRIQDWVNIKRNGKTYKRETNTMPQWAGSCWYYIRYLDPNNDNEFASKEKINYWMPVDLYIGGAEHSVLHLLYARFWHKVLYDLGYVNTKEPFKKLINQGMITSFAYQDENGILIPNDEVEKKDNKFFSKKNNKELKQIVAKMSKSLKNIINPDDIIKEYGADSMRIYEMFMGPLTDSKPWNTQGLIGIFRFLNKIWTIKNKELTKESASKEIISELHKTIKKVTEDIENLNFNTAISSLMIFINELLKHDKNYLEIFKPLTIILSPFAPHLGEELWEYMGETPSIFKSAKWPEYDPNLIIDNTREIVLQINGKIKDKIILNKGTNEEALKSIALKNHKIMQNIQNKQIIKIITVKDKLINIVTR
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SHEB5
Sequence: MLKKDMNIADYDPELFKAIQNETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVYMALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWAKMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGVILSAADDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKVYQQQVVNNAKAMVEVFLERGYKIVSGGTSNHLMLVDLIGRDLTGKEADAALGSANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEVESKELTGWICDILDDASNPAVIERVKGQVLALCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_NEIMB
Sequence: METPKLSVEAIEKGTVIDHIPAGRGLTILRQFKLLHYGNAVTVGFNLPSKTQGSKDIIKIKGVCLDDKAADRLALFAPEAVVNTIDNFKVVQKRHLNLPDEIAEVFRCPNTNCAGHGEPVKSRFYVKKHNGQTRLKCHYCEKTYSRDSVAEA
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: EIN22_POPTR
Sequence: METEFVNANHLPHFLRRALPALGPGLLIAIGYVDPGKWAATVEGGARFGFDLVLPMLIFNFVAILCQYLSARIGVVTGKDLAQICSDEYDKWTCMFLGVQAALSVIALDLTMILGIAHGLNLLFGMDLSTCVFLAAVDAVLFPVFATLLERCKASFLSTCIAGFLLLLYFFGVLISQPEIPLPMNGMPIKLSEDSAFALMSLLGASIMPHNFFLHSSMVLQHQGPPNISKGALCLNHFFAILCIFSGIYLVNYVLMNSAANVFYSTGLVLLTFPDAMSLMEPVFRSPVALCVFSLILFFANHITALTWNLGGQVVLQGFLRLDIPNWLQRATIRIIAVVPALYCVWTSGVEGIYQLLIFTQVMVALLLPSSVIPLFRIASSRQVMAAYKISAFLEFLALISFMGMLGIKIIFVVEMVFGDSDWAGNLRWSTSGGSSTSYTVLLITACSSFCLMLWLAATPLKSATHLDAQVWNWDVQNTVSEPSMQIEEEIFSETRYTEEESIGGQEQLSGPGKSAESYSDVTVANADPDLPVTIMESDQEHHLTTIKENHSEITFSSPGTFYEEETSPIIESVSLSAAMNVVPGSELLGAKKIDIESMDSVEKTVDIDGDFHAEKEDDEGDSWEPEESSKGVPGSTSSLTSDGPGSFRSLSGKSDEGGNGAGSLSRLAGLGRAARRQLASVLDEFWGQLYDFHGQTTQEAKTKKLDALGVDLKPSLLKVDTAGKEFSGYFSSVGGRASDSQIHSSLGDSPNHLRVPSNIDSSYGGQRGPSSLWSNHMQLMDAYAQGPSRSIADSSERRYSSVHTLPSSDGRCIQPATVHGYQIASIINQIAKERGSSSLNGQMDSPAPISPSLGPRNYRDPLTVAMGQKLQNGPSSSQPPGFQNLAVSRNSTLQSERHYHDVYSSGSADDAGKSANTKKYHSLPDIAGLAGPYRDLYMSEKNAQWDKSVGFGSSVSRTGYEQSYYSNTRSGAGAGGPLSFNRLPKGHGDAFSFHMTPDPGSLWSRQPFEQFGVADKSRVVGSGLGNRSNSINREVISPVDPEAQLLQSFRRCIVKLLKLEGSDWLFRQNDGADEDLIDRVAARERYLYEAETREMNCVANMGESPYLYSDRKSGSVLRNDDAAITNIMVSSVPNCGEGCVWRVDLIISFGVWCIHRILDLSLMESRPELWGKYTYVLNRLQGIIELAFSKPRSPMSPCFCLQIPASHQHRSSPPVSNGMLPPASKPGRGKCTTAATLLDLIKDVEIAISCRKGRSGTAAGDVAFPKGKENLASVLKRYKRRLSSKGIASK
What is the function of this protein?
Trafficking signal inducing ethylene response (By similarity).  The nuclear localization is both necessary and sufficient to activate EIN3-mediated transcription and ethylene responses (By similarity).
What are the official names of this protein?
Ethylene-insensitive protein 2.2, PotriEIN2.2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
Protein: YGFZ_ECOSE
Sequence: MAFTPFPPRQPTASARLPLTLMTLDDWALATITGADSEKYMQGQVTADVSQMTENQHLLAAHCDAKGKMWSNLRLFRDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSKEKQVVKEGATTLLWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGSASRLPEAGEDLELKMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDMEPDSIFRVRDDANTLHIEPLPYSLEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_CHLCH
Sequence: MKIYSSIKKRCEHCRIVKRKGKRYVICKVNPSHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MSH3_AJECN
Sequence: MSSSQSTSQLKRKQQTISSFFSKKPVAPNGSTTTTPKDGHVKKTIGHARVHEAPSSEMDVVDGAHDAAVRPDEEGDDDYQIILPSRKRIRSNGEVSTLQRGTLADIDNGHSSKGENELQTGIMGSSDSDRAEQPVKIKSGSSRTEKFRFSSSSLPSSSDPKGNGGCDVLYAISADGDASEDGDEEQKRKQALHQKFVKRLGGPDCLPFSVSRVDAGDAEEAEGAESDAEAEAEIVPVPQKGRGGKKTTTGKLTPMERQIIDIKKKHMDTLLVVEVGYKFRFFGEDARVAAKELSIVCIPGKLRFDEHPSEAHLSRFASASIPVHRLHVHVKRLVEAGYKVGVVRQLETAALKAAGENRNAPFVRKLTNLYTKGTYIDDVEGLEESSGNSGSASTSTGYLLCMAESNAKGWGNDEKVHVGIVAVQPATGDVIYDDFEDGFMRSEIEMRLLHIAPCEFLIVGEMSKATEKLVQHLSGSKTNVFGDKIRVERVSKSKTAAAESHSHVSSFYAGRMNAKGTTGDVAASNLLEKVLTLPEDVTICLSSMIKHMSEFGLEYVFDLTKYFQPFSARSHMLLNGNTLTNLEIYQNQTDHTSKGSLFWTLDRTKTRFGQRLLRKWVGRPLLDKTELEERVSAVEELQDPSKTVQIERLKGLLSKIRADLEKSLIRIYYGRCTRPELLTVLQTLQLIADEYVHLKSPADLGFSSPTITTAIAALPAIRDDVVTYLNKINEEAAKKDDKYCFFREVEETDEITESNLGIADVQHRLQEHCAVAAEILGKKKVQYTTVAGIEYLIEVENSPYNLKKVPASWRKISGTKKVSRFHTPEVVQYMRERDQYKEALAAACDKAFHALLADISTKYQSFRDCILALATLDCLLSLANIASQPGYIKPAYTDKTRISVQRGRHPMVEQLLLDTYVPNDIELHTDETRALLVTGPNMGGKSSYVRQVALISIMGQIGSYVPADSATLGMLDAVYTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRNLRSLTLFITHYQNLSSMAREFPKGELRNVHMKFTESGMDGQDITFLYEVGEGVAHRSYGLNVARLANVPDSVLEVARAKSAELEEKIRKKKMLALAKVAKGFINTDGDAGGPAPALLERVMVGLEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPB_CLOBK
Sequence: MSNLGKVIQIIGPIIDIKFDSENLPDLFNALEINAGDRKVIAEVEQHIGDDTIRAIAMEDTEGLKRGMEALDTGKSVSVPVGKEVLGRLFNVLGKPIDGAGEFTSEESYPIHRPAPSFEEQSVEPEIFETGIKVIDLLAPYQKGGKIGLFGGAGVGKTVLIQELINNIAKEHGGLSVFTGVGERTREGNDLYYEMKESGVLEKTALVFGQMNEPPGARMRVALTGLTMSEYFRDQGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGALQERITSTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRAITELGIYPAVDPLESSSRMLDPRIIGEEHYEVAIKVKNILERYRELQDIIAILGIDELSEEDKLVVGRARKIQRFLSQPFTVAEQFTGMQGKYVPIKETVRGFKEILEGKHDNIPESAFLFQGTIEDVLKKAQQMEI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: L_HRSV
Sequence: MDPIINGNSANVYLTDSYLKGVISFSECNALGSYIFNGPYLKNDYTNLISRQNPLIEHMNLKKLNITQSLISKYHKGEIKL
What is the function of this protein?
Responsible for RNA synthesis (replicase and transcriptase), cap addition, and cap methylation.  Performs also the polyadenylation of subgenomic mRNAs by a stuttering mechanism at a slipery stop site present at the end of viral genes.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The viral polymerase binds to the genomic RNA at two differents sites in the 3' leader promoter thereby initiating either genome replication or mRNA transcription.  In the transcription mode, the polymerase performs the sequential transcription of all mRNAs using a termination-reinitiation mechanism responding to gene start and gene end signals.  Some polymerase disengage from the template at each gene junction, resulting in a decreasing abundance of transcripts from the 3' to the 5' end of the genome.  The first gene is the most transcribed, and the last the least transcribed.  Needs as cofactors the phosphoprotein for processivity and the M2-1 anti-termination protein.  Polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides (By similarity).  Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation (By similarity).  In the replication mode, the polymerase replicates the whole viral genome without recognizing the gene end transcriptional signals.  The ability of the polymerase to override the gene end signals as it is producing the antigenome is probably due to replicative RNA becoming encapsidated with nucleoprotein as it is synthesized (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the paramyxovirus L protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Localizes in cytoplasmic inclusion bodies.
Protein: BETB_PSEMY
Sequence: MPRFAEQQLYIGGQYVAASSGQTFDSINPATGEVLAKVQRASQADVDRAVASAAEGQKVWAAMTAMQRSRILRRAVDILRERNDELAELETLDTGKPLSETRYVDIVTGADVLEYYAGLIPAIEGEQIPLRESSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTSLTALKLAEIYTEAGLPAGVFNVLTGSGREVGQWLTEHPGIEKVSFTGGTVTGKKVMASASSSSLKEVTMELGGKSPLIVFEDADLDRAADIAVMANFYSSGQVCTNGTRVFVPRMLQARFEAKVLERVKRIRLGDPLDDATNFGPLVSYAHMESVLGYIEKGRSEGARLLIGGTRVSDGDYAKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILIYDSEEEVIRRANDTDYGLAAGVVTRDLNRAHRVIHKLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLVTLGHYTRIKSVQVELGGYSSVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: NFYB1_ARATH
Sequence: MADTPSSPAGDGGESGGSVREQDRYLPIANISRIMKKALPPNGKIGKDAKDTVQECVSEFISFITSEASDKCQKEKRKTVNGDDLLWAMATLGFEDYLEPLKIYLARYRELEGDNKGSGKSGDGSNRDAGGGVSGEEMPSW
What is the function of this protein?
Component of the NF-Y/HAP transcription factor complex (By similarity).  The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (By similarity).
What are the official names of this protein?
Nuclear transcription factor Y subunit B-1, AtNF-YB-1, AtNF-YB1, Transcriptional activator HAP3A.
What is the protein family that this protein belongs to?
Belongs to the NFYB/HAP3 subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HO_NEOYE
Sequence: MVNTLANELREGTTKSHSMAENVSFVKSFLGGVVDKKSYRKLVANLYFVYCAIEEELFSNKNHPAIKPIYFTELNRKASLSEDLNYYYGSDWLDFIEPSPATKIYVDRIHTIGHKQPELLVAHAYTRYLGDLSGGQILKKIARGAMNLSDSGGTKFYDFDQIKDDKLFKDQYRAALDMIPLSDVQIQNIVSEANISFTLNMKMFEELNSSSLKIITMLIANTIQKFKAKYKSTLAMVD
What is the function of this protein?
Catalyzes the opening of the heme ring with the release of iron.  Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.
What are the official names of this protein?
Heme oxygenase.
What is the protein family that this protein belongs to?
Belongs to the heme oxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: XRCC3_BOVIN
Sequence: MDLDRLDLNPRIVAAVKKAKLRSVKEVLHLSGPDLQRRTHLSSPDVQLLLRASASLLRGHGVCTALHLLRQEGPFPEQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQLPPRHGGLGAGAVYVCTEDAFPSRRLQQLIAQQQRLRADVPGHVISKIRFGHQIFIEHAADVDTLLQCVREKVPVLLARGMARLVVIDSVAAPFRCEFDGAALALRAQRLLALGAELRRLSCAFRSPVLCVNQVTEAVEEQDLVAGPPGMSPALGITWANQLLVRLLADRQRPEEAPLTPPGRTLRVVFAPHLPASSCSYTIAAEGVRGMPGTACS
What is the function of this protein?
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.  Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway.  Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks.  Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression.  Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR.  Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity).
What are the official names of this protein?
DNA repair protein XRCC3, X-ray repair cross-complementing protein 3.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
Protein: SECA2_STAAR
Sequence: MKHKLDVTINELRLKSIRKIVKRINTWSDEVKSYSDDVLKQKTLEFKERIASGVDTLDTLLPEAYAVAREASWRVLGMYPKEVQLIGAIVLHEGNIAEMQTGEGKTLTATMPLYLNALSGKGTYLITTNDYLAKRDFEEMQPLYEWLGLTASLGFVDIVDYEYQKGEKRNIYEHDIIYTTNGRLGFDYLIDNLADSAEGKFLPQLNYGIIDEVDSIILDAAQTPLVISGAPRLQSNLFHIVKEFVDTLIEDVHFKMKKTKKEIWLLNQGIEAAQSYFNVEDLYSEQAMVLVRNINLALRAQYLFESNVDYFVYNGDIVLIDRITGRMLPGTKLQAGLHQAIEAKEGMEVSTDKSVMATITFQNLFKLFESFSGMTATGKLGESEFFDLYSKIVVQVPTDKAIQRIDEPDKVFRSVDEKNIAMIHDIVELHETGRPVLLITRTAEAAEYFSKVFFQMDIPNNLLIAQNVAKEAQMIAEAGQIGSMTVATSMAGRGTDIKLGEGVEALGGLAVIIHEHMENSRVDRQLRGRSGRQGDPGSSCIYISLDDYLVKRWSDSNLAENNQLYSLDAQRLSQSSLFNRKVKQIVVKAQRISEEQGVKAREMANEFEKSISIQRDLVYEERNRVLEIDDAENRDFKVLAKDVFEMFVNEEKVLTKSRVVEYIYQNLSFQFNKDVACVNFKDKQAVVTFLLEQFEKQIALNRKNMQSAYYYNIFVQKVFLKAIDSCWLEQVDYLQQLKANVNQRQNGQRNAIFEYHRVALDSFEVMTRNIKKRMVKNICQSMITFDKEGMPVIHFP
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.