PharMolix/UniProtQA huggingface dataset:
Protein: SSAS1_HUMAN
Sequence: MWGFLVLKARWLVTPVRTLATEAGQKPSLRGLLDVGNIQHRAARARGLTRGVIRVSPQERSQQNQSAPKGPTPSTRPKPRTLGPQAHSLALQSVDLLFRP
What are the official names of this protein?
Putative uncharacterized protein SSBP3-AS1, SSBP3 antisense RNA 1, SSBP3 antisense gene protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: PELO_SULIM
Sequence: MRILEFDEKRQAAKLHIESEDDLWILHLILEKGDKVVAKTTRDIGLGKESRRIPMTIVLKVDYTEFQEFTNRLRIHGIIEDAPERFGIRGAHHTINLDIGDEIIIIKQQWSKYALDKLKKQADKRSKIIIALVDFDEYLIAIPFEQGIKILSEKSLRSLNEEEGIIEQNALEVATELAEYVKQYNPDAILLAGPGFFKEEVAKKVNNILKNKKVYIDSVSSATRAGLHEILKRDIIDKIMSDYEIAIGAKKMEKAMELLAKQPELVTYGLEQVKNAVEMGAVETVLLIEDLLSSNNQERLAIERILEDIENKRGEIILVPKESPIYFELKNLTGILAILRFRIN
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKUV_BACSU
Sequence: MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLCKEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHALTDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thiol-disulfide oxidoreductase YkuV.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1044_STAA8
Sequence: MEYEYPIDLDWSNEEMISVINFFNHVEKYYESGVTAGDFMGAYKRFKEIVPAKAEEKQIFNTFEKSSGYNSYKAVQDVKTHSEEQRVTAKK
What are the official names of this protein?
UPF0223 protein SAOUHSC_01044.
What is the protein family that this protein belongs to?
Belongs to the UPF0223 family.
Protein: SLX4_YEAS7
Sequence: MELQRAQRNLKFLQNEDYVNVTDQTNLNGESQNAYSLGMETQVPEMQFSLSSDDDSISTQVKSVTAQKSPITQETTKNDTERNKDVDKSCNPVSTSQPDLGESNIEENIFINTQIQSRLDDAEEETNLKLKLEKFKYSFKSSNADDTHSNANVTAKRRPAIRKANSKLKTKPKTKRDPKIIKNITDFNINNYERSRTASLLKQLSGKHKKVLDIIKTQNEGNSDKPPRARNNKGEKATFDTYSEQEWKDIMKLLLQKFPQSEETDLNEVQKFLYGSEKSSSSLDNQESSQQRLWTASQLPPELPDEAIQPEQEERIRDTQSAVNFLSLSQVMDDKSEIMKDEESIIISRGDSTSSQEYGNGLEPQQPVGNVVGEDIELAVGTRINAFSLTDYKACKPMSVEVSRRCENSTDNDYDNISIVSDTTDETSTLFPLDQYRYVFIENDERPPLATDTIGSTQFFTPNTSPLDGIIDLTQESFKAVRSLISPLKVENNKTGVTSQASNQVQVPATRTPTIIPQKNLTTTLKTEEEKNNIGSSIRVKLLQESVVKLNPKLVKHNFYRVEANDSEEEDTEFDDQFCIADIQLVDSSKISTKDSTQNPTTSNDIIDTSAASSIASPEKFCEIMMSQSMKELRQSLKTVGLKPMRTKVEIIQSLQTASQILSTANPDNKGEHGGVANFSKIEIFDHLTELIEAFPDFLERIYTFEPIPLNELIEKLFSAEPFVSQIDEMTIREWADVQGICLRNDKK
What is the function of this protein?
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases.  Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures.  Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.  Has a preference for simple Y, 5'-flap and replication fork-like structures.  It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates.  Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks.  Has Holliday junction resolvase activity in vitro.  Interacts with the structure-specific RAD1-RAD10 endonuclease and promotes RAD1-RAD10-dependent 3'-non-homologous tail removal (NHTR) during repair of double-strand breaks by single-strand annealing.  SLX4 also promotes recovery from DNA-alkylation-induced replisome stalling during DNA replication by facilitating the error-free mode of lesion bypass.  This does not require SLX1 or RAD1-RAD10, but probably RTT107.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CUE_AEDAE
Sequence: MRNLGIAVTFAVLLVIGYVTALEWDAVVTTDSGILFFDKNWTQISSGGHQFHHISAFAYDEVKRKLYFSDLKDPSFRIFSLDTKPEEEYHKVAKLLPKSDQTGYITGLAFDHLERKLYWTEKGTHSVYSVEVDKLGAPANATDGLINLVAQVEENHDLAALTIDECRRHLYWTNSYLQTSSIVRAAMNGTVLDDHKEDVYEPRGISVDHYNNRIYWVEKKYGRAFTVESANLEVQDRQTFLRGEDKIPTHVSPNSQYLYWIDQEDGEVHETMKSDSKVTRVVYKGSRPSALIIRSGLLVEYQKNNPSCKAVVSEIIDNVRKESSEVKDVAQAVTSKPEMITCLNKGILNHNTNSCICLPEYQGTFCEIPICNNFCVHGECVVGADSRPMCKCHAEFEGERCDRNICDGYCLNNGRCALSATGQRSCTCSKNFSGARCETAICTSDYCYNGECFVENEVPECKCNVGYRGDRCEEYTCNNYCLHDGTCILNNDTMLVECRCGSEYTGKRCEIPKRFCSLDNGNPEMQQYCEGVAIAKNLVEPQVTYCKNSFNRTVVYVSLAFTASLVTLVTILCTVRRMYERNRPRITKRFKVTNNTQMTSRPATQCEITIENCCNMNVCETPCFDTKILQKSATKAEDKQFLLDDIESIAGSYRKLPSCVAEKN
What is the function of this protein?
Has a role in spermatogenesis and oogenesis.
What are the official names of this protein?
Protein cueball.
What is the protein family that this protein belongs to?
Belongs to the cueball family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: BIOB_FLAJ1
Sequence: MSMTTKHNWTKDEIIAIYNKPLMDLLYEAATIHRQQHDPNVVQVSTLLSIKTGGCPEDCGYCPQAARYNTGVEGNDLMTVSQVKAQALRAKSNGSSRVCMGAAWRNVKDGEEFDQVLEMVRTINKLDMEVCCTLGMLTENQAQRLAEAGLYAYNHNLDTSEEYYKDVISTRGFEDRLQTIENVRKTNVTVCSGGIIGMGESIEDRAGMLVALSTLNPQPESVPINALVAVEGTPMEEEKPVEIWEMIRMVATTRIVMPETQVRLSAGRTNMSREGQAMCFFAGANSIFAGDKLLTTPNPDVNEDMKMFETLGMVAQKPFIKIMQPKTVEAADSQFAPLGEKPKWSRPGHTIERNIEASIKSKI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: IML2_COPC7
Sequence: MTNGTPGVPGGEPPHPSAEMLASATKGFDYLFANDIVGSREHFNSKDDPFHLMGAGVIAFLEAALGMETNQVTEASRCLALSETGTRKQMKAPKAKTHSRFPAGLEWDIINADAVVLLGLTHALSETYMGYLQCMYSLNNAHSKFTKLYKTVFPAGIDAEEKPPAPAEVAPSSSSTLQVPNGLQHKSSFSSLSSVSSTGSNATLPPAPPSPTQPAVTKSFFSRWLGSSAAAAASEPTLPLHHHQHHHIPDGPVEELIVSGTAFGYGLFNLVFSLLPKKVQSLVGFLGFQHDRKLALKALALSASKKDVHGVFAGLVLMTYHGVVLLLSGWQADEARIINQYKGIIDNVEERYPEGALWILNRAKILRMSCDAEGAIRVLQNGLKPERPHSFAQADMMLLFELAWTLLGQRRYQESADSFMKITELNTWSHATYYFLSAGCHFALGNLEKTQELLDAIPGLIHNKKVGGKDLPTEVFIKKKLAFYKEKQKRRCGDEAKFAEAIRINPAEELGIFWNTHARVSKEICKSHVADVLHLTPALTITSPTITALSSNSNSNPTLPTPASATAAMSSLSLSSKSSTASKTSPPSLSKSKSPLDLDTPDELAVRSLLLGICHRTLEEFDAARKFLLDAHGYQGQVKVNTWVGGVAMFELAVLELKEVEFLEKGGGKVDWMKAMKVADERLDVALSLSPNSVDLSSRLDSRISMLRDEMGIKREMLGGKA
What is the function of this protein?
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins.  Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
What are the official names of this protein?
Inclusion body clearance protein IML2.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Protein: MICU1_XENTR
Sequence: MFRLRFIPAVAGLAAVSRRYHGVANHARSRRRLMMAAFVGATAVSASAGLLWKRANAEAQSSVKHSMREETSEKEKEDADQAVESSDEDQPQEGKKKKARVGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVIHESGESEVFMTPQDFVRSITPNEKQPENLGLDQFIIKRYDGKKISQEREKFADEDSIFYSLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRSTTGNTLKTGFSSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGHITERQFGSMLLAYSGVQSKKLTHMLKQLKKRFKDAEGLTFEEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFIAIMKQRLMRGLEKPKDMGFTRLMRAMWKCAQETAWDFAMPKQ
What is the function of this protein?
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains.  micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits mcu activity, depending on the concentration of calcium.  Micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake.  Acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening.  Enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm.
What are the official names of this protein?
Calcium uptake protein 1, mitochondrial, Calcium-binding atopy-related autoantigen 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the MICU1 family. MICU1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Note=The topology is subject to debate.
Protein: SLD5_BOVIN
Sequence: MAEEADLLGQDSDGDSEEVILTPAELIDRLEQAWMNEKFAPELLENKSEIVECVMEQLEHMEENLKRAKKGDLKVSIHQMEMERIRFVLSSYLRCRLMKIEKFFPHTLEKEKTRREEEPPILSPEELVFAKEFLANTETYLKDTALKHMPPNLQKVDLLRTVPKPDLDAYVFLRVKERQENILVEPENDEQRDYVIDLEEGSQHLMRYRTVAPLVASGAIQLI
What is the function of this protein?
Required for initiation of chromosomal DNA replication.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
What are the official names of this protein?
DNA replication complex GINS protein SLD5, GINS complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the GINS4/SLD5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm.
Protein: LOLD_NITHX
Sequence: MEQGAKEIPVVYLHDIRRQYTQGETKLTILDGTKLALWAGQSVALVAPSGSGKSTLLHIAGLLESPDAGEVYIGGTATSGLSDVERTRIRRTDIGFVYQSHRLLPEFTALENVMLPQMIRGLRRSETVKRAREILSYLGLEDRVTHRPAELSGGEQQRVAIARAVANAPRVLLADEPTGNLDPNTADHVFNALMQLVKATRVAMLIATHNMELADRMDRRVSLENGHVVELD
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RUBR1_CHLTE
Sequence: MNVKESEPAQADLQASWMCAECGYIYDPAEGNLETNIRPGMPFDKLPDDWSCPVCNHPKNQFTKFISQL
What is the function of this protein?
Serves as an electron acceptor for pyruvate ferredoxin oxidoreductase (PFOR).
What are the official names of this protein?
Rubredoxin-1, Rd 1.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: ADRB3_MOUSE
Sequence: MAPWPHRNGSLALWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRHLLRRELGRFSPEESPPSPSRSPSPATGGTPAAPDGVPPCGRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYANSAFNPVIYCRSPDFRDAFRRLLCSYGGRGPEEPRAVTFPASPVEARQSPPLNRFDGYEGARPFPT
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  Beta-3 is involved in the regulation of lipolysis and thermogenesis.
What are the official names of this protein?
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCST_STAA9
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: TRP5_NEZVI
Sequence: APLMGFQGVR
What are the official names of this protein?
Tachykinin-related peptide 5, TKRP-5.
What are the subcellular locations of this protein?
Secreted.
Protein: FABA_SALNS
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTARKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTAHDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_STAHJ
Sequence: MAKQDVIELEGTVLDTLPNAMFKVELENGHEILAHVSGKIRMNYIRILPGDKVTVEMSPYDLSRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE1D_ORYSJ
Sequence: MEKNTAASGQLMTSSAEATPSSPKRPAGRTKFQETRHLVFRGVRWRGCAGRWVCKVRVPGSRGDRFWIGTSDTAEETARTHDAAMLALCGASASLNFADSAWLLHVPRAPVVSGLRPPAARCATRCLQGHRRVPAPGRGSTATATATSGDAASTAPPSAPVLSAKQCEFIFLSSLDCWMLMSKLISSSRAKGSLCLRKNPISFCMVTNSYTALLLEYIILQMNSMIVLIHELSKYQVFLLLTMITHHLFQWRR
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.  Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (By similarity).
What are the official names of this protein?
Dehydration-responsive element-binding protein 1D, Protein DREB1D, Protein C-repeat-binding factor 4.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSH_SALPC
Sequence: MSNVPAELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVKAASDIYAPVSGEIVAVNDALSDSPELVNSEPYTGGWIFKIKASDESELESLLDATAYEALLEDE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: S40A_CHITE
Sequence: MRIKFLVVLAVICLFAHYASASGMGGDKKPKDAPKPKDAPKPKEVKPVKAESSEYEIEVIKHQKEKTEKKEKEKKTHVETKKEVKKKEKKQIPCSEKLKDEKLDCETKGVPAGYKAIFKFTENEECDWTCDYEALPPPPGAKKDDKKEKKTVKVVKPPKEKPPKKLRKECSGEKVIKFQNCLVKIRGLIAFGDKTKNFDKKFAKLVQGKQKKGAKKAKGGKKAAPKPGPKPGPKQADKPKDAKK
What is the function of this protein?
Used by the larvae to construct a supramolecular structure, the larval tube.
What are the official names of this protein?
Salivary gland SP38-40.A protein.
What are the subcellular locations of this protein?
Secreted.
Protein: HYPA_CERS1
Sequence: MHEMSLCEGIRGIVEDQARRHGFATVKVLRLEIGRFAGVEKAALGFAFDVVMRGSAAEGARLEILDLPGRALCYDCGEEAAIEDRFDPCPLCGGGRLMPVGGDEMRIKDMEVQ
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: RL32_BORT9
Sequence: MAVPKFKPSKSRSRTRRSINMRKKIPQFQECSNCGNLAVRHRVCVKCGYYRNSQYLELGL
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CTU2_ASPCL
Sequence: MPGKELTDPCVDCADAEAILTVRCRRLCQDCYARFVNFKVFKRMENYRLRRNMSRTGPCKLLLPLSYGTSSSVLLHILNAQIQHERAKSHPSPGFELHVLVIEPSTVSTSSPPHDEGFDLLQQTFPSHSFTRVSLHNVFELDPSIQDVLSQFSSEGFTDDATMSDKDRLDAFRASITTATSRVDVDYILITRLVVAFAKKIECRGVVWGDSDTRLAAKTLANVAKGRGSAITWQVCDGMSPFGLEFSFPLRDLYKAEVQNYASFFPELAKIIIPDEPPSENILTKNLSIDELMMRYVQTQGEKYPGIMANVTRTASKLQASLVPANVPRCSFCGGSMLNQDGQIIMGGAAGNSEVRQGAELCYACTRSRPEVSY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRN1_ARATH
Sequence: MESEPDQSFKDLSWFLQAIKDPQQTFFNLQTLSFSSSGNTTHCQLITESSMNINVTRDNLTSLSQIFIELATSLETQTSLRNLEFEGIFWEIELLQSLGLLLDNTSKIKQLAFRKNRFSEQCLNELSEILKRNRFLKEVMFLESSIGYRGATLLGSALQVNDSLEELQIWEDSIGSKGAEELSRMIEMNSSLKLFSIFDSSPFTATPLISAVLGMNREMEVHMWSGDHKRDRSLKLVEFLPESKTLRIYQIDISGSCRVAAALGMNTTVRSLDMTGAKLNSRWAKEFRWVLEQNKTLREVKLSKTGLKDKAVVYIAAGLFKNKSLQSLYVDGNRFGSVGVEDLLCPLSRFSALQLQANITLRSIVFGGSNTKIGRDGLTAVLKMVTTNETVVHLGIHDDASLGPDDFIHIFKSLQKNASLRRFSLQGCKGVRGDRVLEAITETLQINPLIEEIDLARTPLQDSGKADEIYQKLGHNGRKIDEAETDDSLKDMPLTEPKSVRAFLCGQNYAGKTTLCNSILQSSSASGFPYVENVRNLMNPVEQVVKTVGGMKIKTFKDEETKISMWNLAGQHEFFALHDLMFPSPCFFLIVLSLFRKPSNKEPKTPAEVEEELEYWLRFIVSNSRKAIQQCMKPNVTIVLTHSEKINLQSESFQATVGCIQRLRDKFQALVEFYPTVFTVDARSSPSVSKLTHHIRMTSKAILQRVPRVYQLCNDIVQLLSDWRSENSNKPIMRWKAFADLCQFKVPSLRIKSRNENIQIVETRRHAIATCLHQMGEVIYFDDLGFLILDYEWFCGEVLTQLIKLDVRKQSTGERNGFVSRKELEKTLRSSLQSPIPGMTSKVLEHFDACDLVKMMKKVELCYEQDPSSPDSSLLVPSILEEGRGKTQKWQINTHDCVYSGRHLQCDDSSHMFLTAGFFPRLQVHLHNRIMELKNQHGATYSLEKYLIAITIHGINIRVELGGQLGNYIDVLACSSKSLTETLRLIHQLIIPAIQSSCRGVILLEHIIRPQCVQDLTPPRFRQSQFVSLHRLKEALSSVPAETMYDYQHTWDSVLDSGKTVLRAGFDLARNLLSDDDFREVLQRRYHDLHNLAQELQVPTDENPEADNHVPVTNELEKVDPSFGGIAKGVEAVLQRLKIIEQEIRDLKQEIQGLRYYEHRLLIQLHHKVNYLVNYNVQMDERKVPNMFYFIRAENYGRRLITSMVPGMVALRIHMLCEFRREMHVVEDQLGCDVMQIDNQAVKCLAPYMTNFMKLVTFALRIGANWAAGMGHMIPDLSHTIAHLANPAVMTGAAGAAGAIGVAAALGRNRGRDRDIQEQEQRAAQQWLIDYLREQTCSTGRDIAEKFGLWRVRYRDDGSIAWICKRHMITRAHEVIQVPL
What is the function of this protein?
Involved in the basipetal transport of auxin (IAA) that modulates growth and organs organization.  Required for initial divisions in the epidermal/lateral root cap leading to the formation of epidermal cells and a clone of lateral root cap cells, as well as for the maintenance of the radial pattern of cell specification in the root, thus regulating the distinction between the lateral root cap and epidermis.
What are the official names of this protein?
Protein TORNADO 1, Protein LOPPED 1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NOCL_NOCUT
Sequence: MTRTDTRSYPFGDPVALDLHPGYAPLRAEQPALRVRLPYGEDCWLVTRHEDVKAVLSDSRFSRARAAGREETPRVTPEAAPAGSMLSMDPPEHSRLRKLIARAFTSRRVREFRPRTQEIVDGLLDQVEQAGAPADLVAGLALPLPVSVISQMLGVPTEDHYRFRDFSATVLSTTAHTREEIVAARAALEEYLGELADQRRREPGEDLMSALVAAHDDDRLTDRELTQTGITLLVGGHESTASQFACSVYLLLERPERWALLRDNPELVPTAVEELLRFIPLGSGGAFARIATEDVEVGGVLVRAGEAVVASTNSANRDDRVFTDPDVLDLAREHNPHLAFGGGVHVCLGAQLARGELQVALTSLLTRFPGLRLAVPPEQVPWRQGSLLRSPVELPVTW
What is the function of this protein?
Involved in the biosynthesis of the beta-lactam antibiotic nocardicin A (PubMed:12105888, PubMed:15629944).  Catalyzes the conversion of nocardicin C to nocardicin A (PubMed:12105888).  Cannot use nocardicin G (PubMed:12105888).
What are the official names of this protein?
Nocardicin C N-oxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RB27A_HUMAN
Sequence: MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRASGPDGATGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHASTDQLSEEKEKGACGC
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381).  Plays a role in cytotoxic granule exocytosis in lymphocytes.  Required for both granule maturation and granule docking and priming at the immunologic synapse.
What are the official names of this protein?
Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). Localizes to endosomal exocytic vesicles (PubMed:17237785).
Protein: QUEE_METTH
Sequence: MILMRAPIVEVFSSIQGEGLLVGRRQIFVRFAGCNLNCSYCDTPESRDPSAGRLFTAPELTEIIEGLITPDFHSISITGGEPLLYPDFITELLEESPHRTLLETNGSLPSNAERIAHLFDYASVDIKIAEHFSDNLRSGTTESDISSPGDLIDREIQVINILISRGVNTYCKVVVMPTTGAGYIGALAERLLECVDEPERLPLVIQPCSPPEQWAQNTPRLLEMSQEAGKYMDVYVIPQMHRALGLR
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Archaeosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: RR3_ILLOL
Sequence: MGQKINPLGFRLGTTQSHHCLWFAQPKNYSGGLQEDEKIRDCIKNYVQKHMRVSSGFEGIARIGIQKKIDLIQVIIHIGFPHFLIEGRARGIEELQINVQKKLNSVNRRLNIAITRVAKPYGQPTILAEYIALQLKNRVSFRKAMKKAIELTEQADTKGIQVQISGRINGKEIARVEWIREGRVPLQTIRAKIDHCSYAVRTIYGVLGIKIWIFLDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.