PharMolix/UniProtQA huggingface dataset:
Protein: SIP2_ORYSJ
Sequence: MKTHERAANLALAGLSLAPLVVKVNPNANVILTACLAVYVGCYRSVKPTPPAETMSKEHAMRFPLVGSAMLLSLFLLFKFLSKDLVNTVLTAYFFILGIAALCATLLPSIKRFLPKEWNDNAIVWRAPLFHSLSVEFTRSQVVASIPGFFFCIWYAAKKHWLANNVLGISFCIQGIEMLSLGSFKTGAILLSGLFFYDIFWVFFTPVMVSVAKSFDAPIKLLFPTGDAARPFSMLGLGDIVIPGIFVALALRFDVSRGIKNRYFNSAFLGYTVGLTVTIIVMNWFQAAQPALLYIVPGVIGFVAVHCLWNGEVKPLLEYNESKAEEEEACEEDTDSKQNKKKE
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.  Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm.
What are the official names of this protein?
Signal peptide peptidase 2, OsSPP2, Intramembrane protease 2, IMP, IMPAS.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VP4_BTV11
Sequence: MPEPHAVLYVTNELSHIVKNGFLPIWKLTGDESLNDLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFISTHKNVQLADIIKTVDVRIPREVARSHDMKAFENEIGRRRIRMRKGFGDALRNYAFKMAIEFHGSEAETLNDANPRLHKIYGMPEMPPLYMEYAEIGTRFDDEPTDEKLVSMLDYIVYSAEEVHYVGCGDLRTLMQFKKRSPGRFRRVLWHVYDPIAPECSDPNVIVHNIMVDSKKNILKHMNFLKRVERLFIWDVSSDRSQMNDHEWETTRFAEDRLGEEIAYEMGGAFSSALIKHRIPNSKDEYHCISTYLFPQPGADADMYELRNFMRLRGYSHVDRHMHPDASVTKVVSRDVRKMVELYHGRDRGRFLKKRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDFALPRSTVMLNGSYRDIRILDGNGAILFLMWRYPDIVKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILDWSAQNKEQKLRDLKRSAAEVIEWKEQMAERPWHVRNDLIRALREYKRKMGMREGASIDSWLELLRHL
What is the function of this protein?
The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP4.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP4 family.
What are the subcellular locations of this protein?
Virion.
Protein: ARM_DROME
Sequence: MSYMPAQNRTMSHNNQYNPPDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGPEEAYEGLYGQGPPSVHSSHGGRAFHQQGYDTLPIDSMQGLEISSPVGGGGAGGAPGNGGAVGGASGGGGNIGAIPPSGAPTSPYSMDMDVGEIDAGALNFDLDAMPTPPNDNNNLAAWYDTDC
What is the function of this protein?
Isoform neural may associate with CadN and participate in the transmission of developmental information.  Can associate with alpha-catenin.  Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate.  Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis.
What are the official names of this protein?
Armadillo segment polarity protein.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Note=Inner surface of cell membrane and adherens junction.
Protein: ACCA_LISMF
Sequence: MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRAFGDDAAIVGGIATFHGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASQAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLNAQAEEINKTITKSLHALMAFSEEQLIEQRYEKFKKIGVYDTL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPO1_HOLDI
Sequence: MSDKNKLLLLFDRPLETVIVPRGPDQEAFDVPVDLLSDRYKAIGVQVSNRFGEETKSKIPVKKISPPPLGEILDLPRQANFSLFIPKHRKIAGRLINIFLGMKDTDDLQSMAIFARERVNPYLFNYCFSVAILHRPDTQDLDIPSFIQTFPDKYLDSQVFSRAREEATLVPEGQRVPIEIPRDYTASDLEVEHRVAYFREDLGINLHHWHWHLVYPFEGAEQVVRKDRRGELFYYMHQQVIARYNLERFCNALKRVTRFTEWKDPIPEAYFPKLDSLVASRAWPARVTDQKLSNLRRDQDQITQDVDDLYRWRDRIYEAIHSGFVQTDGGGRQELTEFGGIDILGNIVESSNLSVNRTLYGDLHNMGHVFISYIHDPDHRHLETFGVMGDSATAMRDPVFYRWHAYIDDLFQQFKGSLPRYTEEQLNYPGITVTGVSVQSQGGAANTLNTFWQQSDVDMSRGMDFQPRGSVFARFTHLNHQPFAYNITVNNASGGNKRGTCRIFLGPKTDERRTAWLFKDQRLLFIELDRFVVNLRQGENTITRNSTESSVTIPFERTFRNLDLSRPVGGEALAQFNFCGCGWPQHMLIPKGTPEGYDCQLFVMISNFDDDQVVQSTEGICNDAMSYCGIKDRLYPDKRSMGYPFDRLPRNNVNTLQEFLTPNMRVQDCVIKFTDRVVVPRPRN
What is the function of this protein?
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.  Catalyzes the oxidation of o-diphenols (N-acetyldopamine, 4-methylcatechol and dopamine).  Cannot oxidize monophenols and p-phenols (L-tyrosine, tyramine, gentisic acid and hydroquinone).  Binds to the surface of hemocytes and is involved in hemocyte melanization.  Activation of the enzyme in response to bacterial lipopolysaccharides (LPS) suggests it may play a role in innate immunity.
What are the official names of this protein?
Phenoloxidase 1, Prophenoloxidase-I.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the hemolymph.
Protein: PPAX_BACP2
Sequence: MNESTINTVLFDLDGTLINTNELIIASFQHTLDHYYPGQYSREEILHFIGPSLFDTFSAMDPDLTDDMIQMYRTFNHEQHDLLVTEYETVLDTLKVLQDRGFKLGIVTTKIRDTVLMGLKLTGLEPFFEVIVTLDDVQNEKPHPEPVQLALSKLGSDPHEAVMVGDNYHDILSGQAAGTKTAGVAWSIKGEEALFKHRPDFMLKKMSDLLAIVGAD
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: YIDZ_SALA4
Sequence: MKKSLTNLDLNLLLCLQLLMQERSVTKAAKRMNVTPSAVSKSLAKLRAWFDDPLFVNTPLGLAPTPLMVSMEQSLADWMQMGNQLLDKPHHQTPRGLKFELAAESPLMMIMFNSLSQQIYQRYPQATIKVRNWDYDSLEAITRGEVDIGFTGRESHPRSRELLSLLPLAIDFEVLFSDLPWVWLREDHPALREAWDLDTFLRYPHISICWEQSDTWALDDVLQEMGRKRHIALSLPGFEQSLFMAAQPDHTLIATAPRYCQHYNQLHQLPLVARPLPFDAQQREKLMVPFTLLWHKRNSHNPKIVWLRQAINTLCRRLI
What is the function of this protein?
Involved in anaerobic NO protection.
What are the official names of this protein?
HTH-type transcriptional regulator YidZ.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RNFH_LARHH
Sequence: MATTDDISVEVAYALPERQSLVRLKVPAGTTARDAIGLSGLLDQYPGIDADTMKIGIFSRPVKADTVLREHDRVEIYRPLIADPKAVRRARAEAGKAMKKGGGDGDTP
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: SUCC_FRATW
Sequence: MNLHEYQAKDLLESYGLKVQKGIVAHNPNEAAQAFDQLGGKFAVVKAQVHAGGRGKAGGVKVVKSSQEAREVAESLIGKNLVTFQTDAEGQPVNSVGVFEDVYPVTRELYLGAVVDRSSRKVTFMASTEGGVDIEEVAHNSPEKILKVEVDPLVGLQPFQAREVAFKLGLEGKQINDFVKTMLGAYKAFIECDFALFEINPLAVRENGEIVCVDGKINLDSNALYRHPKLLALRDKSQENAKELKASEHELNYVALKGNIGCMVNGAGLAMATMDIIQLYGGKPANFLDVGGGATKERVIEAFKLILDDENVKAVLINIFGGIVRCDMIAEAIIEAVKEVNVTVPVVVRLEGNNAEKGAKILADSGLKLIPADGLADAADKVVKSLG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: Y1146_YERPA
Sequence: MLAGMPSLSHEEQQEAVERIHKFMSEGMSSGEAIALVAAEIRERHQNDPQAMAIFEDHDFDEHTESDYRRDDEPDADDIEDPYEG
What are the official names of this protein?
UPF0181 protein YPA_1146.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: ATPD_RUBXD
Sequence: MSAVSTYAEALFGAAREKDELERVLDDLREFCRALRESEELALFFYGEQIPEREKRRAIEALTEGMSPLTTNFLKVLCDNRREEILEDVLRRYEEMVEDHLGRIEVEVVTATELSGEMQERIRERIARVLGGREVILRTSVDPEILGGAVFRFKDRLVDSSIRGRLEGLREAMLERGVV
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ELBH_ECOLX
Sequence: MNKVKFYVLFTALLSSLCAHGAPQSITELCSEYHNTQIYTINDKILSYTESMAGKREMVIITFKSGATFQVEVPGSQHIDSQKKAIERMKDTLRITYLTETKIDKLCVWNNKTPNSIAAISMEN
What is the function of this protein?
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
What are the official names of this protein?
Heat-labile enterotoxin B chain, LT-B, human, LTH-B.
Protein: COAX1_FRATH
Sequence: MIVCIDIGNSHIFGGVFVGDQIKHNFRYPSTTPCTSDTLGIFLLSFFERKKLDIEDIEAVVLSSVVLHLEYSVNSACKKYLGITPLELKPGVKTGLKLDIKNPLDLGADRVANSVAAISLFPSRNIIVVDFGTATTICAISENKTYIGGAILPGINLSMESLSQKTAKLSNVTISHPSSALGKTTISQIQSGLIYGQLGAIKEIINRISQENFIDKPPILIATGGYAHIFEKEQYFDVIISDLLLHGLRIIWQMNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase 1, PanK-III 1, Pantothenic acid kinase 1.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_CROS5
Sequence: MDLTALREEYTRHGLTRDDLEDNPFKQFEKWFQQATEAELSEPNAMSLATASAKGEPSIRTVLLKYFDEKGFVFFTNYESRKAQQIEENPHVALLFLWLPLERQVKIQGTATKVSTAESLNYFTSRPRGSQLGAWCSAQSSVISSRKLLEMKFEELKYKFQHGEIPLPSFWGGYRVKPTRFEFWQGRPNRLHDRFSYTLTETDDTTWGIHRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: DCDB_METHJ
Sequence: MILVDWQITDRIERGYIGIDPYNPELIQPNSIDIRLGNHFVWYTPGDEIIDPYIRDTVTGGTEEMTAESIVLHPGQFVLAETMEAIRLPDNIVASIEGKSSIARLGIELHQTGGWIDAGFAGSITLEMCNVNQRPVRMHAGMPIGQLVFYTTERALCPYNAKKDAKYLNQRQATLSRYYENKKRA
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: CFDP1_CHICK
Sequence: MSGCEEEAGDGYSSAEDEDYVPSGAEYSEEDESELLREEEEEAAGPRPTRSRNSPRQATRRKKKKRRGLVLEVDEKEEGKAQENEDEEDDLKQSEKDREEEEKKKEDALWASFLSDVGQKPKAAATQATHADKAGEVKSVNKLQGKPKESEKPKDSGRVTITKVFDFAGEEVRVTKEVDSSSKEAKSFLKQQEKWQSSAPGSLPTVSGVKRPSGISSLLGKIGSKKQKMSTLEKSKLDWENFKEEEGIVEELAIHNRGKDGYIERKAFLERVDHRQFEIERDIRLSRMKP
What is the function of this protein?
May play a role during embryogenesis.
What are the official names of this protein?
Craniofacial development protein 1, Bucentaur.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: RHD3_CANAL
Sequence: MKFLAILSLSSSALATISSIQLFAKSDDSKVDGLGLYSKHEGAAIDYLFLGKNGADLKYDDEKKQIFQELKTSSITVRQSFTLGGDVYELGATDNFIPVTINKDGTLSFTGDDKVYASKNVNDPYRYSESEYAVSNKKTDDSAPITIVAKFSDDKAAETSGVAQAASSSAGPAQASVSNFEGAAGQNKLSYGVGMAAVVAGLVM
What is the function of this protein?
Component of the cell wall involved in virulence.  Does not seem to have a major role in maintaining cell wall integrity but plays a role in the relationship between C. albicans and the host.
What are the official names of this protein?
Cell wall protein RHD3, LDG family protein 7, Predicted GPI-anchored protein 29, Repressed during hyphae development protein 3.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI- anchor.
Protein: PT1_GEOSE
Sequence: MGNAIREKTIHGIAASSGIAIAKAYRLETPDLAAEKRTVADVEAEIARLEAAVAKAKEELEAIKQHALEKLGEDKAAIFAAHLLVLDDPELLNPIKEKIQTERVNAEYALDETALFFISMFEAMDNEYMKERAADIRDVTKRVLAHLLGVTISNPSLISEEVVIIAEDLTPSDTAQLNRQYVKGFATDIGGRTSHSAIMARSLEIPAVVGTKTVTAEVKNGDIVIVDGLDGQVIINPSPELLAQYEQKRARYEAQKAEWAKLVHEATVTADGIHVELAANIGTPDDVKGALANGAEGIGLYRTEFLYMGRSELPTEDEQFVAYKTVLEQMNGKPVVVRTLDIGGDKELPYLQLPKEMNPFLGFRAIRLCLEMQDMFRTQLRALLRASVYGNLKIMFPMIATLDEFRQAKAILLEEKEALLRQGVAVADGIEVGMMVEIPAAAVMADQFAKEVDFFSIGTNDLIQYTMAADRMNERVAYLYQPYNPAILRLISHVIDAAHREGKWVGMCGEMAGDPIAIPILLALGLDEFSMSATSILPARAQLKKLAKEEAARIKETVLSLGTAEEVVSFVKRTFSLA
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
What are the official names of this protein?
Phosphoenolpyruvate-protein phosphotransferase, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOS_CRIGR
Sequence: MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCADLSGSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAAMVKTVSGGRAQSISRRSKVEQLSPEEEEKRRIRRERNKMAAAKCWNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEATTPESEEAFSLPLLNDAEPKTSLEPVKSISNMELKAEPFDDFLFPPSSRPSGSETTARSVPDMDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
What is the function of this protein?
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.  On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.  Has a critical function in regulating the development of cells destined to form and maintain the skeleton.  It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).  In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A.  This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Protein c-Fos, Cellular oncogene fos, Transcription factor AP-1 subunit c-Fos.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Fos subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity).
Protein: TM38B_DANRE
Sequence: MDVFAFFNLNELAFGLSKLPMFPYFDMAHYIISVMSLREQPGALCVSQRSPLACWFSSMLYCFGGAVLSALMLADAPVAPLSNTTNLLLATLMWYLVFYCPLDVVYSLASLLPLRLVLTAMKEVTRTWKVLSGVSQAGSKYSDALFVMVAVGWAKGAGGGLISNFEQLVRGVWKPETNELLKMSYPTKVTLLGAVVFSLQQCRYLPIQTHHLTFIYTLFTVTNKTRMMLLGSSSHPLSSLESFLYKTLFVRPLTDLSAEHTHSKHNGSVPEPTTAQTHTKEAEASKKTN
What is the function of this protein?
Monovalent cation channel required for maintenance of rapid intracellular calcium release.  May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
What are the official names of this protein?
Trimeric intracellular cation channel type B, TRIC-B, TRICB, Transmembrane protein 38B.
What is the protein family that this protein belongs to?
Belongs to the TMEM38 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: THI1_PANTH
Sequence: MSKVKGFIYKPLMVMLALLLVVVSPAGAGAAHSDASSDITLKVAIYPYVPDPARFQAAVLDQWQRQEPGVKLEFTDWDSYSADPPDDLDVFVLDSIFLSHFVDAGYLLPFGSQDIDQAEDVLPFALQGAKRNGEVYGLPQILCTNLLFYRKGDLKIGQVDNIYELYKKIGTSHSEQIPPPQNKGLLINMAGGTTKASMYLEALIDVTGQYTEYDLLPPLDPLNDKVIRGLRLLINMAGEKPSQYVPEDGDAYVRASWFAQGSGRAFIGYSESMMRMGDYAEQVRFKPISSSAGQDIPLFYSDVVSVNSKTAHPELAKKLANVMASADTVEQALRPQADGQYPQYLLPARHQVYEALMQDYPIYSELAQIVNKPSNRVFRLGPEVRTWLKDAKQVLPEALGLTDVSSLAS
What is the function of this protein?
Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.
What are the official names of this protein?
Thiaminase-1, Thiaminase I, Thiamine pyridinylase.
What are the subcellular locations of this protein?
Secreted.
Protein: LICB_BACIU
Sequence: XXKEIXHIFHDN
What is the function of this protein?
Has antibacterial activity against Gram-positive and Gram-negative bacteria including Salmonella, B. cereus, B. megaterium, L. casei, L. viridescens, M. flavus, C. glutamicum, C. crenatum, L. mesenteroides, E. faecalis, S. flexneri, S. aureus and B. thuringiensis.
What are the official names of this protein?
Subpeptin JM4-B.
What are the subcellular locations of this protein?
Secreted.
Protein: HOLIN_BPK3
Sequence: MAAPRISFSPSDILFGVLDRLFKDNATGKVLASRVAVVILLFMMAIVWYRGDSFFEYYKQSKYETYSEIIEKERNARFESVALEQLQIVHISSEADFSAVYSFRPKNLNYFVDIIAYEGKLPSTISEKSLGGYPVDKTMDEYTVHLNGRHYYSNSKFAFLPTKKPTPEINYMYSCPYFNLDNIYAGTITMYWYRNDHISNDRLESICSQAARILGRAK
What is the function of this protein?
Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space.  Determines the precise timing of host cell lysis.  Regulated by specific antiholins that somehow sense superinfections and then delay lysis.  Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
What are the official names of this protein?
Holin, Lysis protein.
What is the protein family that this protein belongs to?
Belongs to the T4likevirus holin family.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Classified as a class III holin.
Protein: CCA_STRPN
Sequence: MRLTQMPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMRGFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLREKK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: SUS_DROME
Sequence: MSVALADEPLIDLEEDLEDGEIDDDEEDEQQSSKIQVQKKTFVGDDDVQFVGVEAKNQNDDEDVVYVGPSTDAVCLQNSNSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEGLATANPLLQSTRSSRRRKRKKEREREQKKDKEQQNRSRRDENDVSVVPGGVEDMDEYEMMNVRGGSPPPGGAAPPLSSCGQRFSGADWDMDDGSAATGAAGLGAGGGGGYNSHSSYDSYSDEETNGPGLMNQRRRTRRDNEKEHQRGVNNRKRRDRDRLEGGLAGSGSKRNRRDSGEGGGGGQEKMGGSNRVEPRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYLGMDCYAGDDCLFYHGEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIAIVQMTRRHEQLCDQLNRENTWNSIGCGLMGKRQDHQMQQQQQQLQHQQLQQQQEQQQTQQQAAADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAKAAAGAAGSSERDSTSPDAKPLPPHLDLANLSHVLSAENMAKLNKLGITNLEQMLQVPFGQLTEAGLTLVEIGEIQRKAEDAKPQTQAELESSTPPSKRETEANNSNSKSNGLIMVDYTQYLKDAHVSFSGNDPLDDDRDDDEQLIIDDGNDSTAEEDQQPKKAKAPPAATHESSTEEAPLPSVFDLPSFMNNMLGQGSSARQLLPASATSPNQENAHLPGGDQSTHKSAPIGGGTSTNVLGRILFGDKQSDPEARAAFYRDIIRNPFKAHSGDGDVDSSNENSNSNSHSLTPTPTPEPGSQSPKPEDHDQDMPELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQELLTEEKEQYQRDTDMRLPFEPMKHYMPATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKEQRELRDPRMRRILGLPETPDNSGPLGSVPIMGPSSFSVDNIARCATTIASPDLETAVRDSTPSSPPPSVVNLPSMSVPPPSMRVPPPNIQVEKPTVRTDPRRDPRRAVLQAPTKGASTANTTAPNASGGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQLALVFTELKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALGGGGDSGGGVGGGGGGGGVVLPNLSQPPPNLSQMLRLPPPNIRMLRMSGMMMQMGNVGPPFNQPPPRGGLMGMPPNGNGLNQGVGNLGGLGQLGINQGGGPVPNGNPFNPFGGNNGGGAGVMNNMNSMGNMGMGFNNFNNNGGRGGHFPGGGSGGNGNGNNRNQRGGNHRNRNI
What is the function of this protein?
RNA-binding protein that suppresses transcription of some RNAs (PubMed:1703632, PubMed:9121479, PubMed:11027289, PubMed:15082769, PubMed:19687295, PubMed:26577379).  Together with Wdr82, part of a transcription termination checkpoint that promotes transcription termination of RNAs and their subsequent degradation by the nuclear exosome (PubMed:26577379).  Promotes transcription termination of aberrant RNAs, transcripts from genes containing a transposon inserted at their very 5' end or RNAs from heat-shock-inducible repetitive element (PubMed:1703632, PubMed:19687295, PubMed:26577379).  Binds RNA preferentially at a sequence that resembles a cryptic 5'-splice site (PubMed:9121479).
What are the official names of this protein?
Protein suppressor of sable.
What is the protein family that this protein belongs to?
Belongs to the suppressor of sable family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to polytene chromosomes.