PharMolix/UniProtQA huggingface dataset:
Protein: CSC1_SCHPO
Sequence: MAFNGYGIFDSDPRKNPSSDLRTQFWLAFLLGASACVFFCFFRKRWKVLYAPRTTIEGLNLPTLSSSYYKWLMDLVNIPDDVVQNCAGLDGYVFLLFFKMGIKFLSFASLLGVLIIMPVNKHFRGDAFGNITLSMPAKSEYFFSSPLVKKSIVQSPIIANGSELNVGVLGPSLFNPIGNLSDIPGLPQPGDGFLYLYVLFTYFISIFLLYVLFSSTKSIADIRQSYLARQNRLTDRTVFISGLPNELCSTENLKAYFDKLDVGSIDSLSICRNYSYMDILLSKKSKYVKKLEKYWSIYLSNCKKLGISTLPPSNYLSPNRAELESTPEQLLEVPWQHHQCHPLIKTHFFGIFGQKIDAIDFYSAKLYKISQQIENARSFDYPTTGQAFITFESMATAQIVAQTHIDSKSLMGLHIELAPAANDIQWHNTYIGRWHKFFQGWFITLVTFMIILLWTVPVGAIAVFINLDTIRRLWPELGRMIEDLPFLNSLLRTFLPTLVYSLFISISPFLFRWLSSMQGLSSRAEEEIYAVGKNYAYLFVNFFLVYVIAGSTSIWELAKDTTSFAHFLANRLPHQAQFFIDLIVLQGIGMFPLKLIQLGKLSSYFVRRSFVPYSIASKKFETPDSFSVGIFLPQPMFIMLICLCYSIISPLILVFGLIYFIIGFLVYKYELIYQMEHPQHSTGELWSTIFLRMIFGCVIMQLTMMGLMSLRKAYWLSTVIFPLLCFTVISAYNFSTMIRSSMQFVSLYYIRTHQSNTLSSESESRNSESSGSYVHPGFDLSNEELPLIDLNTA
What is the function of this protein?
Acts as an osmosensitive calcium-permeable cation channel.
What are the official names of this protein?
Calcium permeable stress-gated cation channel 1, SpCSC1.
What is the protein family that this protein belongs to?
Belongs to the CSC1 (TC 1.A.17) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: END4_BACCN
Sequence: MLKIGSHVSMSGKKMLLAASEEAVSYGATTFMIYTGAPQNTRRKPIEELNIEAGRKHMEEHGIKEIIVHAPYIINIGNTTKPETFQLGVDFLRMEIERTEALGVAKQIVLHPGAHVGAGADAGIAQIIKGLNEVLTPEQTVNIALETMAGKGTECGRSFEEIARIIDGVTYNEKLSVCFDTCHTHDAGYDIANDFDGVLNEFDKIVGIDRLQVLHVNDSKNVRGAAKDRHENIGFGHIGYKALHDIVHHPQLEHIPKILETPYVGEEKKDKKPPYKFEIEMLKNGTFDEGLLEKIKGQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: GCST_BACCQ
Sequence: MITLQRTPLFDVYAKYGGKTIDFGGWELPVQFSSIKEEHEAVRTAAGLFDVSHMGEVEVKGVDSLAFLQRVVTNDVSTLKVGGAQYTAMCYENGGTVDDLLIYKRGEEDYLLVINASNIEKDYEWLASHVIGDATVVNVSSEVAQLAIQGPKAEGILQKVVSEDLKEIKFFKFKNDILVDGIPALVSRTGYTGEDGFEIYCKSEDAAKLWEKLLEVGAEEGLKPCGLGARDTLRFEATLPLYGQELSKDITPVEAGIGFAVKPNKEADFFGKATLKEQKENGAPRKLVGIEVIERGIPRTHYPVFIGEEKIGEVTSGTQSPTLKKSIGLALIDVKYAAVDTEVEIEIRNKRVKAVVVPTPFYKRSK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: SURE_ECOL5
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_RUEPO
Sequence: MPLNSLGFAKPPSETRVVVAMSGGVDSSVVAAYLADQGYDVVGVTLQLYDHGAALAKKGACCAGIDIHDARRVAEERGFPHYVLDYENIFKDAVIDEFADSYLAGATPVPCIRCNERVKFKDLLETARDLEADCMATGHYIQRKMGPNGPELHCAEDANRDQSYFLFSTTPEQLDYLRFPLGHLPSKDATREMAAQYGLAVADKPDSQDICFVPNGNYASVIEKLRPGAAEPGEIVHADGRVLGSHEGVIHYTIGQRRGLGIGGLSEPLYVVRLDVDRKQVVVGPKELLATRTIPVREINWLGDAPFTSRPEWHLSVKVRSTRPPREAIVRPISETEAEVELLTPEEGVSPGQACVFYESDGSRIFGGGWIWRGY
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPXL_RHIME
Sequence: MRVTATFDKVADIIAETSEIDRETIKPESHTIDDLGIDSLDFLDIVFAIDKEFGIKIPLEQWTQEVNEGKVSTEEYFVLKNLCAKIDELRAAKAG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.  Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).
What are the official names of this protein?
Acyl carrier protein AcpXL.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_ECO8A
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: THII_YERPY
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTTNIRNVLKHLEDDTLAIVRHWDHIELRTKDDNLGPEICDALTRIPGIHHILEVEDRSYSDMHNIFEQTLEAYRETLVGKTFCVRVKRRGKHEFSSGDVERYVGGGLNQHIESAKVNLTRPQVTVNLEVDQDKLILVKARHEGLGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGSAHEIGVKQVAHYLWNRFGSSHRVRFIAIDFEPVVGEILEKVEDGQMGVVLKRMMVRAASQVAERYGVQALVTGEALGQVSSQTLTNLRLIDNASDTLILRPLISHDKEHIINLARQIGTEDFAKTMPEYCGVISKSPTVKAVKAKIEEEESHFDFSILDRVVSEAKNVDIREIAQQSREQVVEVETVAELADTDVLLDIRAPDEQEEKPLKLDQVEVRSLPFYKLSSQFADLDQSKTYLLYCDRGVMSRLQALYLREQGYTNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTA1_CELCE
Sequence: MSKANAKYSFVDLFAGIGGFHAALAATGGVCEYAVEIDREAAAVYERNWNKPALGDITDDANDEGVTLRGYDGPIDVLTGGFPCQPFSKSGAQHGMAETRGTLFWNIARIIEEREPTVLILENVRNLVGPRHRHEWLTIIETLRFFGYEVSGAPAIFSPHLLPAWMGGTPQVRERVFITATLVPERMRDERIPRTETGEIDAEAIGPKPVATMNDRFPIKKGGTELFHPGDRKSGWNLLTSGIIREGDPEPSNVDLRLTETETLWIDAWDDLESTIRRATGRPLEGFPYWADSWTDFRELSRLVVIRGFQAPEREVVGDRKRYVARTDMPEGFVPASVTRPAIDETLPAWKQSHLRRNYDFFERHFAEVVAWAYRWGVYTDLFPASRRKLEWQAQDAPRLWDTVMHFRPSGIRAKRPTYLPALVAITQTSIVGPLERRLSPRETARLQGLPEWFDFGEQRAAATYKQMGNGVNVGVVRHILREHVRRDRALLKLTPAGQRIINAVLADEPDATVGALGAAE
What is the function of this protein?
A methylase, recognizes the double-stranded sequence 5'-AGCT-3', methylates C-3 on both strands, and protects the DNA from cleavage by the AluI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.AluI, M.AluI, Cytosine-specific methyltransferase AluI, Modification methylase AluI.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: CHLB_PLETE
Sequence: MKLAYWMYAGPAHIGTLRVASSFKNVHAIMHAPLGDDYFNVMRSMLERERDFTPVTASIVDRHVLARGSQEKVVETITRKDKEEQPDLILLTPTCTSSILQEDLQNFVNRAATESKSDVILADVNHYRVNELQAADRTLEQIVRFYIEKAKTQNDLATIKTEKPSVNIIGIFTLGFHNHHDCRELKRLLTDLGISINEVIPEGGSIKNLKNLPKAWFNLIPYREVGLMTAKYLEKELNMPFVATTPMGVIDTAICIREIEAILNFTNQSKIDKEPYNFEDYIDQQTRFVSQAAWFSRSIDCQNLTGKKAIVFGDSTHAASMTKILAREMGIRISCAGTYCKHDADWFREQVSGFCDSVLITDDHTKVGDMIARVEPAAIFGTQMERHVGKRLDIPCGVISAPVHIQNFPLGYRPFLGYEGTNQIADLVYNSFTLGMEDHLLEIFGGHDTKQVITKSLSTDSNLTWTIEGLAELNKIPGFVRAKIKRNTEKFARENNISEITIETMYAAKEAVGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: URE2_NOSP7
Sequence: MIPGEIITPAGEIELNVGRPTIKLQVSNTGDRPIQVGSHYHFYEVNTALNFDREQARGMRLDIPAGTAVRFEPGDEKEIILVPLVGTRQVYGFNAKINGNL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPH_ECOL6
Sequence: MNKFEDIRGVAFDLDGTLVDSAPGLAAAVDMALYALELPVAGEERVITWIGNGADILMERALTWARQERATLRKTMGKPPVDDDIPAEEQVRILRKLFDRYYGEVAEEGTFLFPHVADTLGALQAKGLPLGLVTNKPTPFVAPLLEALDIAKYFSVVIGGDDVQNKKPHPDPLLLVAERMGIAPQQMLFVGDSRNDIQAAKAAGCPSVGLTYGYNYGEAIDLSQPDVIYQSLNDLLPALGLPHSENQESKND
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: PIGH_SERS3
Sequence: MNDVTTETYETLKQSVLHTFAQLTGYNVSELSLTSHLENDLGVDSIALAEIAVSLSRQFQLNTPLLIQDINTIKDALDGILQREFQLSEKVEPAAIALSGDADLWLGNLVRQIFASHSGYDVNALALDAEIESDLGIDSVSVASAQGELFNTLQLNSETIIANCNTLSALKQCLAARLVQEKGQDWFEQRGRGQSDSAIDHDADTTAEVTPPTATPVAINAEIGDPRTMRDFVGIEHPDIFHKAREFHLFYQDKKKRQLYFYGMPLETPCKNRAVMFDEATGQHREFLMFGSNSYLGLSNHPEIIHAIQDAASLYGATNTGCRIIAGSNVLHLELERKLAKLKGRDDCIVYPSGYSANLGCISALTSRHDLVFTDAINHMSIQDGCKLAGAQRKIYNHSLTSLEKSLAKYADHPGGKLIVTDGVFSMHGDIVDLPRLMKLAERYGARVLVDDAHSTGVLGKTGAGTSEHFNMKGQVDLELGTMSKALSGLGGYVCGDGDVVEYLRFYSNSYVFAATIPAPVAAGVIASIDVMLREPERLAKLWDNIYYFRTRLLNAGFDLENSDSAIIPIVVGDDAKTLFFGRAVRARGMFCQTVVFPGVSVGDARLRISITSEHTREDLDEAYAILVASALEVGVPVNASAHQEENASVAEA
What is the function of this protein?
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig).  Carrier of the L-malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH.  Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH.  In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrrolyl-beta-ketoacyl-S-PigH) and L-serine to yield 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM).
What are the official names of this protein?
4-hydroxy-2,2'-bipyrrole-5-methanol synthase PigH, HBM synthase, Aminotransferase PigH.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DAPB_MYCBT
Sequence: MRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGEILTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_PECCP
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSASKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PYRDB_PYRHO
Sequence: MVKRMLEVKLFGIRFENPLILASGVVDMTPELLRRAHNEGAGGVVTKSIGKEPRKGYDNPTIVELPYGLINAMGLPNPGWEAFLNEFIDERFDFPVIVSIFGGTPEEFAFLAEKLEPVADAFELNLSCPHAKGYGMEIGQDPKNVYEVVKAVKDVTDKPVIAKLTPNVNDITKLGLAAERGGADGVSAINTVKAIAIDIYAKRPILSNKVGGYSGPGIKPIALRAVYDLAKVLDIPVIGIGGITSWRDAVEFLLAGASALQIGTAVYLRGFKVFKEISNGIIEYLKEEGFSSIRDIIGLALKV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL87_SCHPO
Sequence: MSSKLPKKSEENLELPTFPASEESLSRSEKLKYVFVRNPFIPLGCLMTVGTFLASGYYIRRENHLMANKFMRYRVMSQGFTLAALAFSVLFIGPPRREAPSNSSGSINSEIKK
What are the official names of this protein?
HIG1 domain-containing protein C25B8.07c, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: AMY3_SCHPO
Sequence: MFGVYFVLLFLSSALIHVANAGSNAEWRKRIIYQILTDRFAVDDGSTDNPCDPDANQYCGGTWKGIENKLDYIEDMGFNAIWISPIDKNIEGDIDGAGYAYHGYWNTDYESLNEHFGTEDDLVSLITAAHKAGIWVMLDSIVNSMALAPPLADADYSSLNPFNKESYFHPYCLIDWDITDNETNVMDCWQDSGVLLADLDVESSDVSSYLSDHFKSLISKYDFDGLRIDAVKMMNYTFFPDFVDATGVYSVGEVFSYDPDTMCSYMSVLPGVTNYFLQLYINFSFTATGAGFTLIPTYQEVMASNCSKYDSTLMLTFIENHDLYRFPYYTSDQSQIMGALSFVLIWDGIPSIFYGQEQGFNGGEDPANRPALWLTDYDQSNPYYTVIKTMVAFRKFVITQDPDWVTSTYQSIESAVDHYVGQKNDVLVMFNNMGVTNNLTIYEVETNYTANEVVSDVFGHRTLTVGADKTLTASMTNGYPLIMYPHSKMSGFTLPTVNRTVMPSTSATATTTVYTSYYSPSYSARSFTGTGSIFTISSSSRLILSFKTLVFGLGVTAMLFVLFF
What is the function of this protein?
Has a role in cell wall biosynthesis where it is involved in maintaining cell wall strength and shape.
What are the official names of this protein?
Alpha-amylase 3, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CLPP_BORBR
Sequence: MQRFTDFYAAMHGGSSVTPTGLGYIPMVIEQSGRGERAYDIYSRLLRERLIFLVGPVNDNTANLVVAQLLFLESENPDKDISFYINSPGGSVYAGMAIYDTMQFIKPDVSTLCTGLAASMGAFLLAAGKKGKRFTLPNSRIMIHQPSGGAQGQASDIQIQAREILDLRERLNRILAENTGQPVERIAVDTERDNFMSAEDAVSYGLVDKVLTSRAQT
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_STRP2
Sequence: MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENHTSLRELGKY
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: VM2AL_TRIAB
Sequence: MIQVLLVTICLAVFPYQGSSIILESGNVNDYEVVYPEKVTALPKGAVQQKYEDAMQYEFKVNGEPVVLYLEKNKELFSENYSETHYSLDGREITTYPSVEDHCYYHGRIQNDADSTASISACNGLKGHFKLRGKTYLIEPLKLPNSEAHAVFKYENVEKEDEAPQMCGVTETNWESDLPIKKTSQLNLPLLEKRCIELVMVADHRMYTKYDGDKTEISSKIYEIANNLNVDYRPMKIRVALIGTEIWSTGNLSKVTLSADETLDSFGEWRERDLLKRKSHDNVQLLTGMIFNEKIEGRAYNKSMCDPKRSVGIVRDHRTRPHLVANRMAHGLGHNLGIHHDGDSCSCGANSCIMSATVSNEPSSRFSDCSLNQYSNDIIYNPWTSYCLYNEPSKTDIVSPPVCGNYYLEVGEDCDCGPPANCQNPCCDATTCKLTPGSQCAEGLCCAQCKFIEEGTVCRVAKGDWNDDHCTGQSGDCPWIGYYG
What is the function of this protein?
The function of this complete protein has not been studied, but it may be similar to the function of the disintegrin domain.  A recombinant protein of this domain (409-484) inhibits collagen-induced human platelet aggregation, without having effect on ADP-induced aggregation.  It may act either by blocking the binding of fibrinogen to the platelet receptor GPIIb/GPIIIa (ITGA2B/ITGB3) or by blocking the binding of collagen to the integrin alpha-2/beta-1 complex (ITGA2/ITGB1).
What are the official names of this protein?
Zinc metalloproteinase homolog-disintegrin albolatin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIb sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AIM14_ZYGRC
Sequence: MSSELVKRHGHTHYANIPYGYYVLIVSFFYLVFLGVLRIILKPRAAGFNSSKRSRLAQKLYLVNPVVHLPILLVAVLLPFYRHYSISEHATVYIKRLGRLSYALLPLNLLLNLRPNWLLRNNYTYTDLIPLHKWLSRCIIIIAVVHGILFLINWALGESGTLAKKIANPYNLAGVLLFAPLISMIFFSIGPMRRFSYNAFYVIHNLTGISFIFVVAFHARPSVTIPYLLINIAILLWQGFAKFYYAKRTDILSKNTDYQNTNLVNVQLPRMALPDQFEPACHIRISPYSRLHPLYWLYPSHPFTVASLPSDTVVDLIISESHHPKSFKLELGAPYSVINNFDPAVPRSCLEQAKRVAIVCGGSGISFGLPLYRYFKEIHPVEYIQFIWLVKDAYQLKILDKLDTIGLLDGSNDCHAFITRSVDDPNSNQETAPDLEFELESMTQDVVDENGAFVSERDGSPTSKFKFASINLGRRIDWATDLSQFVEPALVDNTWLLTCGPSDLIESGRQYAADNSINFASEIYAL
What is the function of this protein?
Probable cell surface metalloreductase.  May be involved in iron or copper homeostasis (By similarity).
What are the official names of this protein?
Probable metalloreductase AIM14.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family. AIM14 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KITH_BACC3
Sequence: MYLINQNGWIEVICGSMFSGKSEELIRRVRRTQFAKQHAIVFKPCIDNRYSEEDVVSHNGLKVKAVPVSASKDIFEHITEEMDVIAIDEVQFFDGDIVEVVQVLANRGYRVIVAGLDQDFRGLPFGQVPQLMAIAEHVTKLQAVCSACGSPASRTQRLIDGEPAAFDDPIILVGASESYEPRCRHCHVVPTNKDK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM218_HUMAN
Sequence: MAGTVLGVGAGVFILALLWVAVLLLCVLLSRASGAARFSVIFLFFGAVIITSVLLLFPRAGEFPAPEVEVKIVDDFFIGRYVLLAFLSAIFLGGLFLVLIHYVLEPIYAKPLHSY
What is the function of this protein?
May be involved in ciliary biogenesis or function.
What are the official names of this protein?
Transmembrane protein 218.
What is the protein family that this protein belongs to?
Belongs to the TMEM218 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: GCST_PROMM
Sequence: MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEGTNPKDHLQALVPTDLNRIGPGEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINAACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATKVLERLSGESLASLPRFGHRQVQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLRLEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSGRAIARHGYPLLHNNNKVGEITSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRATVVKRPFYRRPSLS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: NU2M_PERKA
Sequence: MNPLILLLITLTVILGTLIVMMSSHWLMIWMGFEMNMLAVIPLLMKQYNPRSMEAATKYFLTQATASMLLMLAIIINLMYSGQWTFTKFMDPTASIIMTLALMMKLGLAPFHFWVPEVTQGISLTSGLILLTWQKLAPLSILYTITPVINPDLLLMASMLSIAIGGWGGLNQTQLRKILAYSSIAHMGWMMSVLAFNPTMTLLNLFMYILMTSTTFMLFMVASTTTTLSLSLTWNKTPLITTSILIMMLSLGGLPPLAGFLPKWMIIQELTKSNNIILATLMAITALLNLFFYIRLTYATSLTMFPTTNNMKIKWQFKTTKQMNYLPPLIIMSTLTLPLAPAMILLN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: E2F6_MOUSE
Sequence: MSQQRTARRQPSLLVDPAQETVRRRCRDPINVENLLPSKIRINLEENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPREDSITVHIRSTKGPIDVYLCEVEQNHSNGKTNDGIGASPSKSSHPQCPEKEDEPPQ
What is the function of this protein?
Inhibitor of E2F-dependent transcription (PubMed:9403682).  Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9403682, PubMed:18667754).  Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9403682).  E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9403682).  Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity).  Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (PubMed:18667754).  May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity.  Overexpression delays the exit of cells from the S-phase (By similarity).
What are the official names of this protein?
Transcription factor E2F6, E2F-6, E2F-binding site-modulating activity protein, EMA.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.