PharMolix/UniProtQA huggingface dataset:
Protein: GIN1_RAT
Sequence: MVRSGKNGDLHLKQIAYYKRTGEYHPTTLSSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVVVSEEEKKKVLRECHENGPGVHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKSTVIVAPQQHLSVVGNPWSVVTVDLMGPFHTSSRSHVYAMIMTDLFTKWVMILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIDQINVELYRLFGAKEIVISQASGSVNPSESTPSTVKTFLSKHCAEHPETWDEELPALSFAFNVTRVEPTKNSPYFQMFNRNPCLLECPHEGGGEGTSVFARIVAAVREADGVVENQTPAAGQMESSTSEELSKSKVAKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITDSGCAVLRDNTGTRLKRPIKMSHLRPYVREPSEQDSLYLLQGSIVADHDYIGLPEIPVGTYQANILVEDATIGIVDNELLISSKDHELLEYRNSKISALVEDHSSLEKQTFSLLDSSNQVLEYLS
What are the official names of this protein?
Gypsy retrotransposon integrase-like protein 1, GIN-1.
Protein: NQRE_YERE8
Sequence: MEHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGIAVTVVLGISVPANNLVYNLVLRDGALVEGVDLSFLNFITFIGVIAAIVQVLEMILDRYFPALYNALGIFLPLITVNCAIFGGVSFMAQRDYNFPESIVYGFGSGIGWMLAIVALAGIREKMKYANVPAGLQGLGITFITTGLMALGFMSFSGVNL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SHSA9_MOUSE
Sequence: MRRVLRLLLGCFLTELCARMCRAQERSGHGQLAQLGGVLLLTGGNRSGAASGEAGEGVGGSDAPPTRAPTPDSCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDSRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPNLGQISNPYEQQPPGKELNKYASLKAVGNSDGDWAVATLKSPKADKVNDDFYAKRRHLAELAVKGNLPLHPVRVEDEPRAFSPEHGPAQQNGQKSRTNKMPPHPLAYNSTANFKTWDPSDQSLRRQAYGNKGKLGIAESGSCDPLGTRTQHFPPTQPYFITNSKTEVTV
What is the function of this protein?
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus.  Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses.
What are the official names of this protein?
Protein shisa-9, Cystine-knot AMPAR modulating protein of 44 kDa, CKAMP44.
What is the protein family that this protein belongs to?
Belongs to the shisa family. SHISA9 subfamily.
What are the subcellular locations of this protein?
Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Synapse.
Protein: CARA_DESVV
Sequence: MRALLALEDGFVLEGRSFTGPGETGGEAIFNTGMTGYQEVLTDPSYAGQMVCMTYPLVGNYGVTREDMESGKVHVEAFIVKECCKVPSNWRSEISLPDYLKRHGVMGIEGIDTRALTRHLRIHGAMRGVISTQETDPARLVERARALPSMEGQNLVTRVAPAAPYRWDGERPQAVTLEPGGCAWVGKGPRLVVYDFGIKWNILRLLAQQGFDMLVVPPSFKAADVAAVGAQAVFLSNGPGDPATLKDEIAEIAKLAQTYPTAGICLGHQLLGHALGGRTMKLKFGHHGCNHPVKDLTTGRIEISSQNHGFCVDIDSLTDVEITHVNLNDGTLEGFAHKTKPVIAVQHHPEASPGPNDSRYFFARFRNMVREAAGC
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: PCCB_HUMAN
Sequence: MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:15890657).  Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:6765947, PubMed:15890657).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947).  Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
What are the official names of this protein?
Propionyl-CoA carboxylase beta chain, mitochondrial, PCCase subunit beta, Propanoyl-CoA:carbon dioxide ligase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: LIPB_YERPY
Sequence: MMPRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKTEHVLMPGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y889_SYNY3
Sequence: MFALPQAGDRRGEIIKVLLSNGWDYMNGLLTLGKVGEPQIPTPEVLTKILVELGPFYIKLGQLLSTRPDLLPPRYINALTALQSNVPPLPWSAIEDLLQREFPQPLGETFQEIESEPIAAGSIGQIHRAVLQSGETVAIKVKRPGIDVIVEQDSLLIKDVAELLALTEFGQNYDIVKLADEFTQTVKAELNFDTEAAYTNNLRTNLAKTTWFDPNQLVIPKVYWELTNQKFLVLEWLDGVPILTADLTQPPSDKDIAEKKKEITTLLFRAFFQQLYVDGFFHADPHPGNIFYLADGRLALIDCGMVGRLDPRTRQLLTEMLLAIVDLDAKRCAQLTVELSESVGRVNFQRLEVDYERMLRKYYDLSLSEFNFSEVVYEFLRIARVNKLKVPACLGLYAKCLANLEGAG
What are the official names of this protein?
Uncharacterized protein slr0889.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
Protein: RL10_STRGC
Sequence: MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRRELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFAKNADALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVADNKEDAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NU4C_OENEH
Sequence: MNSFPWLTIIVVFPILTGSLIFLLPHRGNKVMKWYTLCICILELLLTTYTFCYHFQLDDPLTQLTENYKWIHFFDFYWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDAQLFHFLMLAMYSGQIGSFSSRDLLLFFLMWEFELIPVYLLLSMWGGKKRLYSATKFILYTAGGSIFLLIGVLGIGLYGSNEPTLNFETLANQSYPVALEVIFYVGFLIAFAVKLPIIPFHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLPHAHCLFSPGLIIVGAIQIIYAASTSPGQLNLKKRIAYSSISHMGFIIIGIGSLSDTGLNGAILQIISHGFIGAALFFLAGTSYDRIRLLYLDEMGGMAIPLPKLFTMLSILSMASLALPGLSGFVAELLVFFGIITSQKYLLMPKILIAFLMAIGMILTPIYSLSMLRQMFYGYKLFNVPNYYFFDSGPRELFVSISLLLPIIGIGIYPDFVLSLSVEKVEAIISHFFFSIVFKKKE
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL9_LARHH
Sequence: MQIILLEKVANLGQLGDVVKVKDGYARNFLIPSGKAKRATEANLQAFEARRAELEAKQAEILVDAQARGEKLNGVTITIAQKAGVDGRLFGSITNADIAEAIIASGVQVQKSDVRLPNGPFKAIGEYNVEVALHHDVVVEIQLVVNAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RS15_ACIC5
Sequence: MLAPVKKTEIISQFRTHDSDTGSPQVQIAILSERIGELTEHFKTHAKDHSSRRGLLKLVSKRRRLLDYLKLHDTDSYRDVIGKLGIRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: MINK1_MOUSE
Sequence: MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEISGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
What is the function of this protein?
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking.  Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons.  Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway.  Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1.  Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
What are the official names of this protein?
Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Protein: MXI1_HUMAN
Sequence: MERVKMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
What is the function of this protein?
Transcriptional repressor.  MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'.  MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
What are the official names of this protein?
Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDC_PORG3
Sequence: MDKNTVIGLVLIGLVIFGFSWLNRPDPQEIEAQRKAAIEAARQDSIAKAEAELLAARTQEATPDSIKQAAGYNQYGLLAAATAGAEEQVELANGKIALKLSTKGGAIREVLLRDYKTYDGKPLYLFREGESDFNLPLRTLDNRLVDTRDLYFSPISRTDSSVVMRLAVDSASYLDLAYVLLPDDYRLRMTVSGQNLQSLFPANMTMQDLEWSQRIRRQEKSWKFENQYTSIYYKYSGDEVDRLSDSKQEDKKTLEEPLHWVSFKDKYFASVLVCDSYFENNKLAQKTAAAGSDYLKNCTMSATFPLDVRPGTKAGFTFFFGPLKYNMLRAYDKGMKAEDNLDLDHLVYLGASIFRWINRYMIIPASTFLQQYFSNWGLIILLLTLGIKLLISPLAYKGYLSSAKMRLLRPQVQEINAKYPGKDQESMMKRQSATMNLYRAAGAGPMSGCLPMLLQFPFLIAMYMYFPTTIDIRQQSFLWAEDLSSYDAVFSWTADIPLLSQFYGNHVSLFCLLMSISNILYIRYTMNQSDTGQEGMAMLKWMPYITTVMFLFFFNQNASGLCYYYFLSSIITVIQYMSSRFIINEEKLMAKLEANKTKPRKKSKWMARLEEAQRQQEAMRRQQQKRK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_SYMTH
Sequence: MEVKASARFVRIAPRKVRVVIDLVRGKSVNEALALLKFIPKRASEPVAKVIASAAANAEHNFSLNKDNLYIAKAYVDQGPTLKRYHPRQRGQAFPILKRTSHITVVVKEKEAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RS13_STRPQ
Sequence: MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDIRVKDLTSDQEDAIRREVDAIKVEGDLRREVNMNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MATK_RANMC
Sequence: MEELQRYLKMDRSRERDFLYSLLFQEYIYALAHDFGLTKSIPYESMQILSYDNKYSSLIVKRLIIRMYQQKHLIILDNDSKNKNFLGHNKNLYSQMISEGFAVIVEIPFALRLVSSYQGKEIEKSINLGSIHSTFPFLEDKFVHLNHVLNILIPYPIHFELIVQNLRCWIQDASFLHLLRFFLYEYHNWNSFTTQKMKQNSLFLKENRRFFLFLYNFHVYESESIFLFLRKKSYHLRSTSSIAFLDRTHFFGKIEHLKVVFRNDFHTMLWLFKDPFMHYFRYQGKSIMSSKGTPLLMKKWKYYLVNLWECHFYFWSQPNRIHINQLSNIFLNFLGYLSSVRPNPSVVRNQMLENAFIIDISRNKLSTLVPIIPLIGSLAKAKFCNLSGQPISKPAWTDSLDSDIIDRFGRICRNVSHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRSFLKRLGSEFLEEFLIEEEQVLSFILPKISSSSQRLSKERIWYFDIIRINDLMDL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIB1_SCHPO
Sequence: MDKKEGDQVHHDKTLLQDLSLPENVASEKRLPIDDVQCVNSPMLSPALDIEPKPNVVGTAERLPKVRCVVRARIPTVKGTEIFLHLYKNDFDNKEHLAIVFGQQIRSDSLDAVQEGETEMDRMVRGAYVGTLYPGRKSSYIDVNSSKTTEEQKEEARKTNFVPLVRIHSECYTGETAWSARCDCGEQLDEAARLISEEGNGVIIYLRQEGRGIGLSEKLKAYNLQDLGNDTVQANLLLQHPADGRSYAVATAMLMDLGQRDIRLLTNNPEKVNSIEGPNKEVRVVERISMIPKSWRGEKGIESAEVVLYLKTKIEKMGHLLDLPDS
What are the official names of this protein?
Probable GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PDRP_SORC5
Sequence: MDKAKFIDVLSDSTGETAEKAVRAALLQYPDAGVQIRLHTRVRTPEVARPVLERAAQEGALVVFTVVSPELREFVHASTAELNIEAIDLIGSLIVRLGTFLDREPINLPSAMLPLSEEYFRRIEAVEFAVKSDDGKEPRNFKRADIVLVGVSRTSKTPLSTLLAQRGLKVANLPLVLGVPPPLELMEAPQDRVVGLTIGIDQLCEIRQARLRQLGMPSETNYAMREHVRQELDFANRLFAAHPEWPVVDVTKRAIEETAVIILEHLKERDERAKVVRSSLV
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: RNZ_TRIEI
Sequence: MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFITHMHGDHVFGLMGLLASCGLGGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSKPGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVEKAKALGIPPGPIYRKLKQGEFVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEMAFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYDFLSYEIPRWNEVSQLLAKARS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL3_BORT9
Sequence: MLGLIGKKVGMTQVFQGNGVVVPVTVIEFEPNYVIGKKTVERDGYDALIMGSVDLRSSKISKPIRGQYKNLENVEPKRYVIEFKGLKGYDAGDEIGLDAFREIKYVDITGTTKGKGFQGAMKRHNFSGGPSSHGSKFHRHLGGTGQATTPARTFKGTKMAGRMGGEQQTIQNLEVVFIDEEKRAILVKGAVPGVKGSFVIVKKAKKVGV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: FAM50_AEDAE
Sequence: MAYYKGAASEGGRAMQLMKKREIAQQEIEFRKKKIEEDLKVSNIESKFATHYDAVEQQLKTSTIGLVTLDEMKQKQEDIVREREKKLAQKKEEKDREKLKALEAKQAEKDRQRKQIQALSFNPEEDEESFDDEDEEEPLEIKPHKWQTEECTEPRIKKIKKNPDVDTSFLPDREREEMDNKLREELRQEWAMKQATLKDQEIPITFSYWDGSGHRKCVTMKKGNSIYQFLQKCLEMLRKEFSELKTVMADQLMYVKEDLILPHHYTFYDFIVTKARGKSGPLFSFDVKDDIRMISDASVEKEETHAGKVLLRSWYERNKHIFPASRWEPYDPTKVYDKYTIKDKCKK
What are the official names of this protein?
Protein FAM50 homolog.
What is the protein family that this protein belongs to?
Belongs to the FAM50 family.
Protein: RHAD_SALTI
Sequence: MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDEADIAPFSADFHEKPRYITLSQLMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGPDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLNETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVELY
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Putative rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTX3L_MOUSE
Sequence: MASSPDPPSPLLVRLRESIPKAHRKLEIYFQSRASGGGECSVQPVGPSAPDTYEVKFLKKADKEKVLKKSEHEMLVHNKPVTIVLETTKKPVEDLRPRLPSLTQPVETPSSRPPSLTGSLDEALCDDIHPQDGLVSNSVDSVVQKIFLAVTAELNCDLLSKEQRASITTVCPHIIKSMEGSDGIKKVCGNFKDIEKIHHFLSEQLLEREQKRKGSEQKRKCAPQKHTPPDVEREPPDQSSIQVPVLLLEYFKHVNPGRLEFIEYKFGVNIEIQASSPNMVTVGFTSSPFGNVEEASQSFVRDFQKCSQSLKQDCISLEEHQRAKEVRQELSRCFPKLLIKGQGRTLTLLGSPADISAATEKVSQGLGLRPVKITASGYTTGIEVDSTRFKLLEPELLQEISEIEQKFNTRGKVQEKGQKTCILFVPKDKDLDLSVQSYTGFTDAFQRATWQLRTEVLSLKGLGKERARLHNTKFADNFKKEHPNVHFVTSQESVTLTGLPHHLAQAMQYVSKRMGLAPSSGEKLAMDQETPMEISSSDPHGDQQENAALPAPRGTSSSPAASKGTEDYCVICMDTISNKHVLPKCKHEFCTSCISKAMLIKPVCPVCLTSYGIQKGNQPEGTMSYSTQKGSLPGYEGCGTIVINYEIKDGIQTKEHPNPGKAYHGTRRTAYLPDNTEGRKVLDLLHEAFKHRLTFTIGYSRATGVSDVITWNDIHHKTSKFGGPANFGYPDPDYLKRVKEELKAKGIE
What is the function of this protein?
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses.  Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4.  In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1).  The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me).  PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.  By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication.  Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM.  In addition, required for the recruitment of HGS and STAM to early endosomes.
What are the official names of this protein?
E3 ubiquitin-protein ligase DTX3L, Protein deltex-3-like, RING-type E3 ubiquitin transferase DTX3L.
What is the protein family that this protein belongs to?
Belongs to the Deltex family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Localizes at sites of DNA damage in a PARP1-dependent manner. Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM. A minor proportion localizes to lysosomes.
Protein: UVRC_SYNY3
Sequence: MVATVSSTSLLEQPELLERRLQEIPQEPGVYFMGDRQGEILYIGKAKKLRTRVRSYFRDSQPHTARIALMVQQVAEIEFIVTDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYVCITWSETYPRIFITRKRRLNQAKDRYYGPYVDSFSLRQTLRLIQRIFPLRQRRQPLFKHRPCLNYDIGRCPGVCQELITPEDYRQTLQKVAMVFQGRTQELHQLLTQQMEKAAADLKFEQAALIRDQINSLGKLNADQKVSLPQDTISRDAIAVASDGQISAIQLFQIRAGRLVGRLGFFADGVESELEKGEVLQRVLEQHYQQVEAVEIPSEVILPCALPDGELLNDWLTSQRGRKVTFNLPQRQTKAELLEMVERNAQYELERLQKQTAKNVTALEDLAEILNLETLPKRIEGYDISHIQGSNAVASQVVFIDGVPAQQYYRHYKIKNPSIKVGHSDDFASLAEVIIRRFQSSVKGKKNQQDWPDLIMIDGGKGQLSAVVKVLKKMDLLDKFTVVSLAKQREEIFLPGESQPLPTHAEQPGVQLLRRLRDEAHRFAVSFHRQQRLSKSRRSRLDEIPGLGFSRQKQLLAHFRSLDYIREASVKQLQEVPGIGPQLAQTIYDYFHPVNS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.