PharMolix/UniProtQA huggingface dataset:
Protein: METK_RUEST
Sequence: MSRTNYTFTSESVSEGHPDKVCDRISDAVLDALIAEEPEARVAAETFATTNRVVIGGEVGLSDQAKLKDYMGKIDEIARACIKDIGYEQDKFHHETVEITNLLHEQSAHIAQGVDAAGDKDEGAGDQGIMFGFATDETDALMPAPIQFSHAILRRLAEVRKNGTLPVLGPDAKSQISVRYDAGKPVEVTSLVLSTQHLDEKLTSADIRALVEPYIRETLPEGWLTDNTVWHVNPTGKFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLAHKCTLQLSYAIGVAAPLSIYVNTHDTGAVPDENIETAIRKCMDLTPRGIRTHLGLNKPIYQRTAAYGHFGRAPEADGGFSWERTDLTEALKGAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_SHEHH
Sequence: MDMEKTFNLTRRDDGIAILTMDVPGETMNTLRSEFGPEISDVLAEIKADTSIKGLVLVSGKKDSFVAGADISMLDACETATDAKQLSQQGHVVFNELESLPIPVVAAINGACLGGGLELALACHKRVCSLNPKTMMGVPEVQLGLLPGGGGTQRLPRLVGVTTALDMMLTGKQLRPKQALKMGLVDDAVPESILLRTAVEMALAGKRPAKKKHQSFFNKVLEGTSAGRNIIFDQAGKQVAKKTQGNYPAPAKIIDCVRQGMTKGMAKGLEVEASHFADLVMSKESGAMRSVFFATTEMKKETGAGDVEPQKVNKVMVLGGGLMGGGIASVTTTKAKIPARVKDISETGLSNALAYAYKLLDKGVKRRHMTPAVRDNLMALMTTTTEYKGIKDADIVVEAVFEDLALKHQMVKDVERECGEHTIFASNTSSLPIGQIAEAASRPENVIGLHYFSPVEKMPLVEVIAHEKTSAETIATTVAFAKKQGKTPIVVQDGAGFYVNRILALYMNEAAQLLLEGQSVEHLDKALIKFGFPVGPMTLLDEVGIDVGAKISPILEKELGERFKAPTAFDKLLADDRKGRKNGKGFYLYGGKKKAKEVDQTVYSVLGLKPGVDTEATEVAQRCVVQMLNEAVRCLEESIIACPRDGDIGAIFGIGFPPFLGGPFHYIDTLGAANLVKILENYQSRYGSRFEPAAKLKQMAEEGTRFFS
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_SALTY
Sequence: MSESPKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVNGKSRLLRGLDGNKDQSYFLYTLGHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFRDFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKDGSEDPWYVVDKDVENNVLIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTLRCTVKTRYRQTDIPCTINALNDDRIEVIFDEPVAAVTPGQSAVFYSGEVCLGGGIIEQRLPLTV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSTT_SALPK
Sequence: MATQRASGLLQRLAQGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPVLVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAQDIVPPSGIVEVLRGLLMSMVSNPIDALLNANYIGILVWAVGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPVGIFGLVSSTLATTGFSTLWGYAHLLVVLIGCMLLVALVVNPLLVFWKIRRNPYPLVFACLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGVPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGIPNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDERLANNALRS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H12_GLYBA
Sequence: MSDPAPEVAPAAPVASPAKAKKEKKPKSDKPKKPKAPRTHPPVSEMVVNAIKTLKERGGSSLQAIKKFLVAQYKVDVEKLAPFIKKYLKGGAVVKGELLQTKGKGASGSFKLPAAAKKEKVAKKPMKATGEKKPKAAAKPKKAGEKKKSIAKKPKAATATKVKKPVAKSTKKQAAVKPAAKKAAPKPKAVPKPKAAKPKKEAKPKKAAAPKAAKKPAQKKPKATKKPAAKKA
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1-II.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL29_ACIBS
Sequence: MKTKDLREKSVEELKALLDEQQLNQFRLRMAKATGQLGKSHEVQVARKTIARIKTLLTEKQGNGQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: GAO_SAUCO
Sequence: MELSFTTSIAVATIVFVLFKLATRPKSNKKLLPEPWRLPIIGHMHHLIGTMPHRGVMDLARKYGSLMHLQLGEVSTIVVSSPKWAKEILTTHDITFANRPETLTGEIIAYHNTDIVLAPYGEYWRQLRKLCTLELLSVKKVKSFQSLREEECWNLVQEVKESGSGRPVDLSENIFKMIATILSRAAFGKGIKDQKEFTEIVKEILRQTGGFDVADIFPSKKFLHHLSGKRARLTSIHKKLDNLINNIVAEHPGNNSSKSNETLLDVMLRLKDSVEFPLTADNVKAIILDMFGAGTDTSSATVEWAISELIRCPRAMEKVQAELRQALKGKDKVKEEDIQDLSYLDLVIKETLRLHPPLPLVMPRECRQPVNLAGYDIANKTKLIVNVFAINRDPEYWKDAESFIPERFENSPITVMGAEYEYLPFGAGRRMCPGAALGLANVQLPLANILYHFNWKLPNGASHDQLDMTESFGATVQRKTHLVLVPSF
What is the function of this protein?
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:20351109).  Catalyzes three consecutive oxidations of germacrene A to produce germacrene A acid (PubMed:20351109).  Could also catalyze the three-step oxidation of non-natural substrate amorphadiene to artemisinic acid (PubMed:20351109).
What are the official names of this protein?
Germacrene A hydroxylase, Germacrene A oxidase, SlGAO.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RL22_SYNFM
Sequence: MEVRAVSKFLRVSPHKARLVADLVRGKKVSDALTILKFTPKKSGRFINKTLRSAVANAENTKSMDVETLFVKSIFVDKGPQLKRWRPRAMGRATKILKGSSHITIILAEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MURE_ZYMMO
Sequence: MSGTEKKLGFLASGYGLSPKEKDYPVLGFAVDSRKVAKGFVFGAFPGAKVNGEDFIEKAIAAGAVAIVARPEVKIEGAVHLVAENPRLAFAEMAARFYAPFPPVMAAVTGTNGKTSVAELCRQLWTITGHKAASIGTLGVITAKNSYSLGMTTPDVVTFLSCCSDLARADISHVIFEASSHGLDQYRSDGAKVIAGAFTSFSRDHLDYHGTMERYLAAKLRLFDERIAPDGTAVIWADDPAATTVIAHVQKRGLKLIDIGEKAEAIRLVNREADSQGQMITLSIKGESYKIRLPLIGGYQLSNALVAAGLVLATGGDIKQTMAALTLLKPVRGRLERATQSQNGAEVYVDYAHTPDGLRAAIEALRPHTEGLLWVVFGAGGDRDKGKRPEMGKIAANLADHVIVTDDNPRGEDAATIRKEVLVGAPLAEEIGGRKEAIFSAIKRAEKGDIVLIAGKGHEQGQIIGRGETMRVLPFDDVTVAKEAVL
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOCOS_DROMO
Sequence: MVEYTAEFTAEEQALIDKEFARLGESTYLDHAGTTLYAESQVLSAAQQLQRDVICNPHTCRATGDYVDQVRYRILEFFNTNADDYHVVFTANATAALRLVADHFDFAGDGNFHYCQENHTSVLGMRQLVKAKGIYMLTKDDIELNVLDQPSTPAPAAAATAQANSLVTFSAQCNFSGYKMPLTVIEQIQKRGLQQLGKCIWSAESQPAAKNVDSNYYVCLDAAAFAASSPLDLQRFRPDFVCVSFYKIFGYPTGVGGLLVSRRGAEVLRKRFYGGGTINYAYPHTMEHQLRNVFHERFEDGTLPFLSIVELLQGFRTLERLVPGRSIERISRHVHGLARYCEHQLKQLKHPNGAPLITLYNHAGYEDRAKQGGTVAFNVRTNTGDYVGFGEVACMAALHRILLRTGCFCNVGACQHFLQLNDETMDAIYKRAGRICGDYFDLLDGQPTGAVRVSFGYMTRIQDVDRFLQMLRNSYLVIAKPQQRFSFIEQQAELLPKALQQRAQRLRPRLLQLAIYPVKSCAAFKIDSSTGSWPLTKQGLQYDREWMIVDMNGMALTQKRCTDLCLIQPRIVGDQLELHYAETSCSMPLSLSVQAANSARCHSKVCRQAIEGYDCGDEVATWLSQSLGLEGVRLLRQSAQRSAPGTQQQQLSLVNQAQFLLVNRASVRSLQFEESLDETVDRFRANIIIDTGTPFEELTYTQLRIGDILFQVDGPCQRCDMICINQRTGERSPETLTTIARMQSGKMRFGIYISRLPSETDDRLEQQQQLTCGDVIVVS
What is the function of this protein?
Sulfurates the molybdenum cofactor.  Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
What are the official names of this protein?
Molybdenum cofactor sulfurase, MCS, MOS, MoCo sulfurase, Molybdenum cofactor sulfurtransferase, Protein maroon-like, Ma-l.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Protein: EFTU_EHRRG
Sequence: MVDGRKPHINVGTIGHVDHGKTTLTAALTTVLAKRLSGEGNKSVKYDEIDKAPEEKARGITISTAHVEYETENRHYAHVDCPGHADYIKNMITGAAQMDAAILVVSATDGAMPQTREHILLAKQVGVKDIVVWMNKCDVVDDEEMLSLVEMEIRELLTKYGYPGDDIDVVKGSAVKALEEESADGVWSEKIMELMNALEKIDLPIREKDKPFLMSIEDVFSIPGRGTVVTGRIERGVIKVGDKIDIVGLRDIQSTVCTGVEMFHKALDAGEAGDNAGILLRGIKKEDVERGQVLSAPGQIHSYKGFKAEVYVLKKEEGGRHTPFFSNYQPQFYVRTTDVTGNIKLPDGVEMVMPGDNISIEVNLDKPVAIDKGLRFAIREGGRTIGSGIITEILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_HERA2
Sequence: MTTPRPVLLAIMDGWGLAPAGPGNGVSLANTPNVNHWMATCPTTQLHASGLDVGLPEGQIGNSEVGHLNIGAGLVVYQDSTRISESIKSGEFFENPAFLEAVQIVKERGTNMHLIGLIGRGGVHAYDIHLAGLLQLMAQQGVNHTYIHAFMDGRDTLPQSGLGYMRELQQTISQIGVGQVASVIGRYYAMDRDKRWERVGAAYAAMVEGVGHTASDPISAIEQAYLRDARGDEFIEATVITDSAGVALPRISTGDVVICFNFRADRVRQITRALMQSDLNTMIQEWYANQAEQGLQLPTTIWQRPEQVSNLHYVTMTQYDATFPYAIAYPPHYITEPLAKVIADAGKRQYHSAETEKYPHVTFFLNGRREEPFAGEDRVMAASPKVATYDLQPEMSAEEVAAKLLDAVNSQIYDFLVVNFANPDMVGHTGVIPAVVKACETVDRCLGQVVPAVVAQGGAAILIADHGNAEQMIDPQTGGPHTAHTTNLVPCILVADPATGLTREQISLRAGGRLADLAPTILDLLGLQKAAAMTGTSLIETK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: FKB10_MOUSE
Sequence: MFLVGSSSHTLHRLRILPLLLLLQTLERGLGRASPAGAPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLYFDVVLLDVWNKADTVQSTILLRPPYCPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLVFYVLLLDVHNPKDTVQLETLELPQGCVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFHNPSDPVEIKTLSRPPENCNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGVPGSAVLLFEVELVSREDGLPTGYLFVWYQDPSTSLFEDMDLNKDGEVPPEEFSSFIKAQVNEGKGRLMPGQDPDKTISDMFQNQDRNQDGKITAEELKLKSDEDQERVHEEL
What is the function of this protein?
PPIases accelerate the folding of proteins during protein synthesis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP10, PPIase FKBP10, 65 kDa FK506-binding protein, 65 kDa FKBP, FKBP-65, FK506-binding protein 10, FKBP-10, Immunophilin FKBP65, Rotamase.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PTRN1_CAEEL
Sequence: MDFPLPALLAIEDYDENEGKLAASIRWLISRVYEEKRDMPDKLRDGVQRDENGHFQIDEAVVGALCNGSLYAQAAAKIFKESALVTKGHGAVLAVLTDYGIDVLHDGNELVEEAQLVASAPFNMSAHLAIIDALMMAHLRDVIPVSRVVEAVSRHTAVEPSEKPIDSVDALLFWINKICLLVRDDVEREDSNTNIPEMEDLYEDISDGQCLCALLHWYRPHEMPVADISFNDSATTRDCQYNLMLLQLFCRHHLAVDPFHFEIEDLLYLRDSLQMNVNAFLADLFVQFEPPVTPEPVETPRIGPSPRRFVPASAIPDLRAANAAARSSMHNRNRPRMYNPPPAVSHSQGPSRSVSRMSQDSLFYSRPASIALQRRSMDQDSVTDFQTIRQGFENQAGTAQLNRYDGSVTASVRLAMEEKRRKHDQQMAQMSFSSANETERLEKSKAAFFALRKNDNDQTSKGKEEWYDHFEAKLRALELRVGLEEGEDGTQSARLNRASSQPSVVQAGQTYPANYMTLPMNAAAQMTQSYIQHPQTPHDYYMQQQMQQQQQQQAQAQSNYASPSQLRNSLSNGMINHAGYIVQSMYPGDYQQQQQQMQMQQGQMPVQPVGAYTPEGYFIPHHMQPIPVQQGYQQMPQPGMGFNGMPATSQPGFNMEGSPAQMGYIQTANKPLDMEMPMQQQPPQQPPQQMLPPNQNAFHLHSKSDDATQVQADPPLEINRNLTNWGMTYKQEMPARSIPSRRTWQNETFIKNELDLVNSKESVPHITDETTTQPEEAARRFPDLMLDNHSENLAPGRGFSRQNDRDDLSTGRKSDDSPTDTPGRTFDDDEGSGENMEKIANERRIAKKAALIAKTMKRKEEIETKVDLAEQRNAERRQVENEKKELALRKKVEKEQQRQKILDEYKRKKLEKELGAELSARSTGRGHSQPPFIRTKSQMSEVTESSRQNTPRMRGQSSVEQRVSVSSLAEPTHKLYAKTVTKSNRGLINNALQFSVFPGAVNNATRQATITQMASSSSKHFLILFRDQKCQYRGLYTWDEISDTAVKISGQGPPKCTEAMMNSMFKYDSGAKNFTNIATKHLSATIDGFAILDQYWQKARIPHSGTPAHKNN
What is the function of this protein?
Required for microtubule stability and anchorage by binding to the minus ends of microtubules (PubMed:25437544, PubMed:26371552, PubMed:27661253).  Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis (PubMed:26371552).  Promotes microtubule stability and polymerization in neurons (PubMed:24569477).  Involved in the maintenance of neurite morphology in ALM and PLM neurons (PubMed:25437544, PubMed:24569477, PubMed:24569480).  May play a role in synaptic protein localization in the PLM neuron (PubMed:24569477).  May act upstream of dlk-1 in neuronal regeneration (PubMed:25437544, PubMed:24569480).  Plays a role in postembryonic epidermal tissue integrity and wound healing (PubMed:27661253).
What are the official names of this protein?
Patronin (microtubule-binding protein) homolog.
What is the protein family that this protein belongs to?
Belongs to the CAMSAP1 family.
What are the subcellular locations of this protein?
Cell projection, axon. Cell projection, dendrite. Cell membrane, sarcolemma. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Perikaryon. Note=Localizes to puncta throughout the dendrites and axon of neurites, within the cytosol of muscle cells and at the sarcolemma (PubMed:24569477). Expressed in puncta along the dendrites of neurons and in the perikaryon (PubMed:25437544, PubMed:24569480). Localizes along microtubules (PubMed:27661253).
Protein: CUTI2_COLKA
Sequence: DINGGA
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (PubMed:17043825).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (PubMed:17043825).  Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (By similarity).
What are the official names of this protein?
Cutinase 2, Cutin hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: KCAB2_MOUSE
Sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
What is the function of this protein?
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:8576199).  Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (PubMed:11825900, PubMed:21209188).  Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity).  Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:8576199).  Modulates the functional properties of KCNA4 (By similarity).  Modulates the functional properties of KCNA5 (PubMed:8576199).  Enhances KCNB2 channel activity (PubMed:8824288).  Modulates the functional properties of KCNA5 (PubMed:8576199).  Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity).  Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).
What are the official names of this protein?
Voltage-gated potassium channel subunit beta-2, K(+) channel subunit beta-2, Kv-beta-2, Neuroimmune protein F5.
What is the protein family that this protein belongs to?
Belongs to the shaker potassium channel beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated.
Protein: RS4E_META3
Sequence: MANKGPRKHLKRLPAPKNWQISRKTNKYTTRPSAGPHAMGSSLPLLLVLRDLLGYADNAREAKKVIKMGKVLVDGVKRKDHRYPTGLMDVISLPDANESFLVVLDEKGRIKLNKIKDNTKKLCKIENKTVIKGGHIQLNLHDGRNQIVKLADATKAEEDIYKTGDCVILSIPEQSIVGHVQFGEGKLAYITGGKHVGDFAKIIGIEKKQLYPDIITLETENGEQFKTIRDYVFIVGDDKPVISM
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: GL8D2_BOVIN
Sequence: MALLRKINQVLLFLLIVTLCGILYKKVHKGTMLRNEADDDSETPEEMEDEIPVVICAAAGRMGAAMAAINSIYSNTDANILFYVVGLRNTLSRIRKWIEHSKLREINFKIVEFNPVVLKGKIRPDSSRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSSQDIHRLVGLQNTYMGYLDYRKKTIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHGKYSTINPLWHIRHLGWNPDTRYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESWFVPDPAGIFKLHHPNS
What are the official names of this protein?
Glycosyltransferase 8 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RL10_HAEDU
Sequence: MALNLQDKQAIVAEVNEAAKGALSAVVADSRGVTVEKMTELRKSAREAGVTMRVVRNTLLRRAVEGTEFECLTDTFTGPTLIAFSNEHPGAAARLFTEFAKTNKEFELKGAAFEGKVQNVEFLATLPTYEEAIARLMGTMKEAAAGKLVRTFAALRDKLQEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RERG_BOVIN
Sequence: MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVTMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS
What is the function of this protein?
Binds GDP/GTP and possesses intrinsic GTPase activity.  Has higher affinity for GDP than for GTP (By similarity).
What are the official names of this protein?
Ras-related and estrogen-regulated growth inhibitor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I47A0
Sequence: MNPNQKIITIGSICMVVGIISLILQIGNIVSIWISHSIQTGNQNHTGTCDQSIITYKNSTWVNQTYVNISNTNVVAGKDTTSVILAGNSSLCPIRGWAIYSKDNGVRIGSKGDVFVIREPFISCSHLECKTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKEILRTQESECVCVNGSCFTIMTDGPSGGPASYKIFKIEKGKVTKSIELDAPNSHYEECSCYPDTSKVMCVCRDNWHGSNRPWVSFDQNLDYQMGYICSGVFGDNPRPKDGKGSCGPVNVDGADGVKGFSYRYGNGGWIGRTKSNSSRKGFEMIWDPNGWTDPDSNFLVKQDIVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVDWSWPDDAELPLNIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: PURA2_PIG
Sequence: MAFAETNPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase isozyme 2, AMPSase 2, AdSS 2, Adenylosuccinate synthetase, acidic isozyme, Adenylosuccinate synthetase, liver isozyme, L-type adenylosuccinate synthetase, IMP--aspartate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.