PharMolix/UniProtQA huggingface dataset:
Protein: RP132_VACCA
Sequence: MDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLLSFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVMTKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVFINKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRHYKISLDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMPPEVVYLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEFKYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIYHTSRYPDRDSMVCHRILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGLNHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPDQVKISKMFSVRKYHPSQYLYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSYYKDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEVGITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTFSDIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAEFRDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLMYPERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQRGGLDIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLVRLNAFLESGDAIARNISSRTLEDDFARDNQISFDVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKFTTRTSQKGTVAYIADETELPYDENGITPDVIINSTSIFSRKTISMLIEVILTAAYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDEELSDKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGKKTKLIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQDVYVCENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNARGVKVKLDFERRPPSFYKPLDKVDLKPSFLV
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of D6 and A7, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 133 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: KCY_NITEC
Sequence: MKNQYVPVITLDGPSASGKGTIARLVSQALGFHYLDSGALYRLVALAAMKRGVDAGDEQGVVGIARSLDVSFADSSIRLDGIDVSDEIRAEACGEYASKIAQYSALRVELLERQRDLRKLPGLVADGRDMGSVIFPDATLKIYLTANEEERARRRHKQLMEKGINASIAHLVLALRERDERDSKRVASPLQQCEDTRLLDTTGLNIDQVVGKVLGMYADSGSIE
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_CAPHI
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETVWTILPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PYRDA_PEDPA
Sequence: MDRLETTIAGVKLKSPVMNASGTAAYGQQMAKNIDLNELGAFVIKSTTMEPRAGHPWPTTAATTGGWLNAVGLKNPGIEHVLAYELPWLAENYPDLPIVGSIAGSNPDDYVEVAKRMATAPNVKFIEVNISCPNVAKGGLAFGTDPVVVEDMTRRIKAVVPNKPVFMKLTPGVTEIVPIALAAERGGADGLVMINTLMGMEIDLETRKPRLSNGTGGLSGKAIHPIAVRMIHQVREVTNLPIIGVGGVFSAKDALELMVAGAGAVQVGSANYGNPHACHDIIQGLVPAMDQYHFNNIAEFSSEK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Putative dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_FRATN
Sequence: MKKTTLLVILDGWGYSDSDYFNAIKNANTPTWDSIWQEFPKTLINASSLEVGLPRGQMGNSEVGHVNIGCGRVVYQELTKIDKAIEEKTFGDNKAIGAAIDNVIKNDSNLHLIGLLSPGGVHSHEEHIFEMIKIAKQKGIKRLYLHAFLDGRDTPPRSAEKSIKKADKLLQDLNLGYIASVCGRYYAMDRDNRWDRVEKAYNAIVNANADFIYDSALEALEQSYARDQSDEFVIPTCIKKDGHLVKVQDNDSVIFMNFRADRAREISHAFTDESFDHFPRKKHLNINFTTLTEYDSKLKCAVAFPPEQPINTLGEVLMKNHKTQLRIAETEKYPHVTFFFNGGREEQFEGEDRILIPSPKVATYDLQPEMSAPEVTDKLVAAINSGKYDCIVCNYANSDMVGHTGNYEAAMQAIEYLDKCIARLKDAILEHDGNMFITADHGNADMMVNPETQKPHTAHTTNLVPFVYVGHKKAQVALEHGKLSDIAPTLLNVMGIAQPKEMTGKTIFNFEK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: APAH_PHOLL
Sequence: MSTYLIGDIHGCYRELRALLTKANFDPTKDTLWLTGDLVARGPDSLKVLRYVKQLGSAARMVLGNHDLHLLGVYAGISRNKPKDKIDTLLSAPDADELINWLRKQPLLQFDDDLKLLMTHAGITPQWDLETAKMCASEVETMFNSSCYPLFLNSMYGDMPNNWSPELSGLARLRFSTNALTRMRYCFPNGQLDMLCKDKPENAPAPLKPWFELERQIPPEYAIVFGHWASLEGQGTPDSFYALDTGCCWGGQLTMLRWEDKQYFTQSSLPAVKQH
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: SYT_STRA1
Sequence: MIKITFPDGAIREFESGITTFEIAQSISNSLAKKALAGKFNGQLIDTTRAIEEDGSIEIVTPDHEDALGVLRHSAAHLFAQAAKRLFPDLCLGVGPAIQDGFYYDTDNKSGQISNDDLPRIEEEMKKIVKENHPCIREEISKEEALELFKDDPYKVELISEHAEDGLTVYRQGEFVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGNSDNAMMQRVYGTAWFDKKDLKAYLKRREEAKERDHRKLGKELDLFMVNPEVGQGLPFWLPNGATIRRELERYIVDKEIASGYQHVYTPPMASVEFYKTSGHWDHYREDMFPTMDMGDGEEFVLRPMNCPHHIEVYKHHVHSYRELPIRIAELGMMHRYEKSGALTGLQRVREMTLNDAHIFVTPEQIKDEFLKALNLIAEIYEDFNLTDYRFRLSYRDPEDKHKYYDNDEMWENAQAMLKEAMDDFGLDYFEAEGEAAFYGPKLDIQVKTALGNEETLSTIQLDFLLPERFDLKYIGADGEEHRPIMIHRGGISTMERFTAILIETYKGAFPTWLAPQQVSVIPISNEAHIDYAWEVARVLKDRGIRAEVDDRNEKMQYKIRAAQTQKIPYQLIVGDKEMEEKAVNVRRYGSKATETKSIEEFVESILADIARKSRPDEVK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNAA_ECOBW
Sequence: MENFKHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVAFSNYFFDTTQGHSQINGCTVRNVYIKEAFDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAKKYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSAKKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAGIRAVEIGSFLLGRDPKTGKQLPCPAELLRLTIPRATYTQTHMDFIIEAFKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: GLYA_NOSP7
Sequence: MTRTNSDFLSSTDPAIAELINDELQRQRDHLELIASENFTSAAVLAAQGSVLTNKYAEGLPGKRYYGGCEYIDKIEQLAINRAKQIFGAAHANVQPHSGAQANFAVFLSLLQPGDKIMGMDLSHGGHLTHGSPVNVSGKWFQVSHYGVSQQTEQLDYDQIRELALRERPKLLICGYSAYPRIIDFEKFRSIADEVGAYLLADIAHIAGLVASGLHPDPIPHCHVVTTTTHKTLRGPRGGLILTSDAELGKKLDKSVFPGTQGGPLEHVIAGKAVAFGEALKPEFKTYSAQVIENARALAEQLQNRGLKLVSNGTDNHLLLVDLRSVNLTGKQADQLVSTVNITANKNTIPFDPQSPFVTSGLRLGSPAMTTRGLGVAEFTEIANIISDRLLSPDSDVVTQDCRQRVAALCDRFPLYPHLEIPVPALA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_NITSB
Sequence: MAKYVGAHVSASGGVENAPKNAQAIGAKAFALFTKNQRQWKAKPLSKENIEKFNEHLECCGIEKKHILPHDSYLINLGHPEEEKRQKSLEAFLDEVRRCEQLGLDKLNFHPGSHLKKISEEECLDRIADAMNETLRQSSGVTLVIENTAGQGSNLGYKFEHLRYLIDKSIDKSRVGVCLDTAHMFAAGYDIRTKEAYDKTMQAFDEIVGFEYLKGMHINDSKAKFASRVDRHHSLGKGEIGLDAFRFIMNDPRLDDIPLILETIDDTIWDKEIELLYSFVE
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: TSP21_CAEEL
Sequence: MIDLKSIWNDKRKITYFFLANVCFLISGLSSLIVGVWLYSSKNNFIELTPTSYSALSAAGLCVFTGVTIFIIVAVGYLGVSWSNKSLLYSYIGFVILLILVHGIARITGSLHKEEAKENLRKSMLHNINTTAVVTKIGREIKLSLTWDHLQRELQCCGVDNYTDWHYSVHWPNNLYTPDSCCDPQHFDAENGTENCGKLPDEQSLLYQKGCFPKFSDWLYHHIILVNWVTSILFVVEILLLILSLVVLRVLKNSRHKTRRSHRERDPETTSENMRLNSMDRIADARLETDTVEDGMSINSR
What is the function of this protein?
Regulates cell fate specification in the postembryonic mesodermal M lineage and body size, probably by positively modulating BMP-like Sma/Mab signaling at the ligand-receptor level.  Promotes ventral fate specification in the M lineage, probably by positively modulating lin-12/Notch signaling.
What are the official names of this protein?
Tetraspanin-21.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Specifically localizes to the basolateral side of intestinal cells. Localizes to cytoplasmic vesicles in the M mesoblast.
Protein: GPR6_RAT
Sequence: MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV
What is the function of this protein?
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP.  Promotes neurite outgrowth and blocks myelin inhibition in neurons.
What are the official names of this protein?
G-protein coupled receptor 6, Sphingosine 1-phosphate receptor GPR6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor (By similarity).
Protein: MV3K_PICTO
Sequence: MENYNVKTRAFPTIGIILLGGISDKKNRIPLHTTAGIAYTGINNDVYTETKLYVSKDEKCYIDGKEIDLNSDRSPSKVIDKFKHEILMRVNLDDENNLSIDSRNFNILSGSSDSGAAALGECIESIFEYNINIFTFENDLQRISESVGRSLYGGLTVNYANGRESLTEPLLEPEAFNNFTIIGAHFNIDRKPSNEIHENIIKHENYRERIKSAERKAKKLEELSRNANIKGIFELAESDTVEYHKMLHDVGVDIINDRMENLIERVKEMKNNFWNSYIVTGGPNVFVITEKKDVDKAMEGLNDLCDDIRLLKVAGKPQVISKNF
What is the function of this protein?
Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate.  Functions in an alternative mevalonate pathway, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.  Also able to catalyze the formation of isobutene via the conversion of 3-hydroxyisovalerate (3-HIV) to an unstable 3-phosphate intermediate that undergoes a spontaneous decarboxylation.
What are the official names of this protein?
Mevalonate-3-kinase, M3K, ATP:(R)-mevalonate 3-phosphotransferase, ATP:(R)-MVA 3 phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: BIRC5_FELCA
Sequence: MGASSLPPAWQLYLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLSEFLKLDKERAKNKIAKETNHKQKEFEETAKRVRCAIEQLAALE
What is the function of this protein?
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity).  Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity).  Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity).  Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity).  The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity).  May counteract a default induction of apoptosis in G2/M phase (By similarity).  The acetylated form represses STAT3 transactivation of target gene promoters (By similarity).  May play a role in neoplasia.  Inhibitor of CASP3 and CASP7 (By similarity).  Essential for the maintenance of mitochondrial integrity and function (By similarity).
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export (By similarity).
Protein: IQM2_ARATH
Sequence: MGVSFSCPFAEQDDVEAALDSVTVKSISFGDDDECKTPKRSVNFNDGTLEPTILKSMGSGKMVVEKSVSLKGMQLERMISLNRSVKDNGFEIAKEFSVLDPRNPKHEAAIKLQKVYKSFRTRRKLADCAVLVEQSWWKLLDFAELKRSSISFFDIEKHETAISRWSRARTRAAKVGKGLSKNGKAQKLALQHWLEAIDPRHRYGHNLHFYYNKWLHCQSREPFFYWLDIGEGKEVNLVEKCPRLKLQQQCIKYLGPMERKAYEVVVEDGKFFYKHSGEILQTSDMEDSESKWIFVLSTSKVLYVGKKKKGTFQHSSFLAGGATVAAGRLVVENGVLKAVWPHSGHYQPTEENFMDFLSFLRENDVDITDVKMSPTDEDEFSIYKQRSTHMRNHSLEEDLEAEKTISFQDKVDPSGEEQTLMRNESISRKQSDLETPEKMESFSTFGDEIQSVGSKSTKVSEDYDSGDDEEEEEEMFELEQESMPSEQSSPRGEEKEEGETKESEVVKITEESILKRINSKKETKSFQLGKQLSCKWTTGAGPRIGCVRDYPSELQFQALEQVNLSPRSASVSRLCFSSSSQTQTPQMSPLWRGMSLPTDITLTNS
What is the function of this protein?
May be involved in biotic and abiotic stress responses.
What are the official names of this protein?
IQ domain-containing protein IQM2, IQ motif-containing protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HISZ_MICAN
Sequence: MIHQPPAGTRDLLPLEVTQKGWINDRLQSVFQRWGYQRIVTSTIEWLDTLTAGGAIDPSTVIQLHGDSQGLSGLRPELTASIARSAVTRMSGESYPQRLCYRANVFRRPSAGYHGRQVEFYQAGVELLFSGGLLADAEILLLLADCFDSLAVPNWQIILGEAGLTRSLLSPFPAPLREQVKRCLALLDYVSLENLPYPNETLRQQARQLFHLRGNPEDVLAQVALLAQEESAQKAVNNLKSLVELLNADRSGPFPLILDLSLIQTFDYYTGIVFKAVSDHQQNLSILGQGGRYDQLLGVFHPQGQSAPGIGFSLNIEELHESLLSGQTLPTQAAPLDWLLIPLGNNAQIATFSKARSLRNGDPNLRVAIDLGGRSEAQIRTYARDRMIKNLAWVQEDGSVSEESL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENH_YERPA
Sequence: MTTLACRKLAPHPESPRHQHAGPWLVWLHGLLGSGQDWLPVAQLCGDYPSLLIDLPGHGQSVSLSADGFADISRQLSQTLQANGIREYWLAGYSLGGRIAIYHACYGRHHGLQGLLVEGGNLGLENAELRQARLQQDRQWAQRFRQEPLPQVLDDWYQQAVFADLDPQQREQLVLLRADNHGPAVAEMLEATSLGHQPWLLPALQRLNVPYTYLCGDRDHKFLQLAQQYRLPLHTLARAGHNAHRANPGAFAAQVLAFLSQSSCLPPSSLSR
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: CHEB2_METMA
Sequence: MSNQHPKKVLEMVIRALIVDDSALIRKVLSDILNQDPKIAVIGTAINGEDGLEKVRKLKPDVVLLDNIMPVLDGLKTLSHIMEEFPTPVVIVSALGEKAEEITLTALEYGAVDVIEKPSGILSQSMHEMAEEICAKVRAVSKADLNNLGCIRDLEHQIPENHRKKKNSLREKTSVRNVLAIGASTGGPRALEKLIGSFPAEIPAAVLIVQHMPPGFTASLSKRLDAKSALRVKEAQEGDIMEEGTVFIAPGDYHMEIVRNKVNGFGEDTVHLSCGPKELGSRPSVNVLFRSVARIYGPRVISLVLTGMNCDGADGAEEIKKMGGKVIAEDQSSCVIYGMPGEIVRRNLADFVLPLDKMADEIVKIVR
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL321_SACEN
Sequence: MAVPKRRKSRSNTRHRRSQWKAAAPDLVPIVVDGERRLVPRPLVRYFQQG
What are the official names of this protein?
50S ribosomal protein L32 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: FABH_BRUME
Sequence: MIRSVVRGIGSALPKRVMKNTDFEGIVETSDEWIVQRTGIRERHIAGEGETTVSLGAAAARAAIENAGLQPSDIDLVLLATSTPNNTFPASAVAIQRELGITRGFAFDLQAVCSGFIYAITTADLYIRGGMARRVLVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAAEGHGLTSDRGILAANLRSDGNHKEKLYVDGGPSTTQTVGHLRMEGREVFKHAVGMITDVIEASFEATGLTAEDIDWFVPHQANKRIIDASAKKLHIAEEKVVITVDRHGNTSAASVPLALATAVADGRIKKGDLVLLEAMGGGFTWGAVLVRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBQ4_ARATH
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGSF
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin 4.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.