PharMolix/UniProtQA huggingface dataset:
Protein: PKS16_DICDI
Sequence: MTFNNIKDENNDDIAIIGMGFRFPGGGNNPDQFWNQLSNKMDGISKISQEKWSRSFYEQKYINNEYGGVLKDEEWKNFDPLFFGISPKEAPTIDPQQRLLMTTLWEAFEDANIKPSTLRGSDTAVFIGMMNLDYQRCQFRDISYINPYTVTGSAGSFVSNRLSFSFDLRGPSMTLDTACSSSLNAVYLGCQAIATGDSKMAIVGGVNGIFDPSISMTFSGLNMLGHKGQCRSFDAGADGYIRSEGGGVCILKKYSDAIKDGDRIYCVIKGGSSNVDGYNAKTNITQPSMKAQGENIEIALKKSGVNPSDIYYIEAHGTGTPVGDPIEIEAISRIFKDNHTPDAPLYIGSVKSNIGHLESAAGIASLIKVALSLKNRSLVPNIHFEKPNPLIKFEDWNIRVVTDEIQFPTNKLINMGINCFGLSGSNCHMILSEAPINYDELLKTTNNNSTSSSSNDDKKEYLIPFSANCNISLDKYIEKLISNQSIYKDTILFKDFVKHQTISKSNLIKRKVITASDWDDFLNKRNETTSTSSLTSTISAPASSTPVIYVFTGQGPQWRDMGKALYETESVFKDAIDHCDKLLANYFGYSILQKLRSLESDDSPEIHHPILAQPSIFLIQVGLVALYKSFGISPSIVVGHSFGEVSSALFSGVISLETAVKIVYYRGLAQNLTMGTGRLLSIGIGADAYLEKCALLYPEIEIACYNDPNSIVITGSEQDLLGAKSTLSAEGVFCAFLGTPCSFHSSKQEMIKEKIFKDLSDLPESNVPCVPFFSTITGSQLSHKGFYNVQYIYDNLRMPVEFTKAISNIFNFIEENESYKNAIFLEIGPHPTLGFYIPKCKPSNSTITSKPIIVSPLHKKKEELTQFKLAISTLYCNGVEIDFASGQQLLPTSSSSGGGDISSFKESTNKLPRYQWDFEEYWDEPNQSKMVKRGPSNNLLGHDQFAGNTLMELFIDINKSAHQYLKGHKIKGKYLFPGSGYIDNILRQFNGQDITIFNLEFSNPFFLKDGVQHHLQTSITPTTKGEFKVEFFIKDNRNSTKWTKTSNGRIGLFKHNPKNNKLDIEKLKSQCSFTTLTKSEVYNKLLLLSLPYGPTFQRVESCSIGDGCSFFKLSMSPCSEFDKDFLNPSIIDCAFHGLLVLSEGPQEIVFDRLQDMKFYSSNVPSTRPQFIYAFAKFDKIVGNSTHGSLDIMLEDGTLLISIKNVKCTSLIRLKKQSIKYPSQNVYSHHWQSKDSPLTLIENQLIEEKSSESKINFEKLLNDKLFNDYLIRLLNQSIKSEFIEFDYKTSTVDTLEIDSNNTKLLEKIQSILKTIDSLDQSIDLASLKQVIIEKSSSFKKEINLIEKSIKRIVSLLKGGESEHFSPSNPSSPNDTPRYNSNNCSSKSNNTSSGADDDTNNEETINQLNNEPFNFSNSQFISNQNQLISKTIVNSFDRLINSIEIGEKKLIKIIDLSSIYQNNQLSKLLLLQLNQLLINLSNNNNIEIEYTIPSNTKNIDSIKEETKSISNLLNIKYRSFDLQDDLESNGYLNSNYDLIITSLLLVSTNSIDSNEVLSKLYKLLLPKGQLILMEPPKDVLSFNLLFANDFKQSLEIKSEQEIKSLIRYCGFTKIETNNITQDDEEEQQQPPSILIVQTEKRDIESMSLTFSSDPESLNSSYSNCIFIVSKEQKENPTSYIQEYFDITEVFCDNTTIIEAGDSELLTKTIESGIGKNDIIFFLVSLEELTIENYKQVTMQYTLVNQILLRNNLSTRFALLTYDSQNGGKNYLGSSLIGTFRYFLEFPSLNTFSIDVDKDSIDNLTLFLRLVDLSTIGDRETIVRNNKIFVQKIFKEPKLLSPSNNYEKDTNNLYLNTNSNLDFSFQCKEKLPHGSVEIKVMSTGINYKDNLFYRGLLPQEIFTKGDIYSPPFGLECAGYITRVAPSGVTRFKVGDQVVGFASHSLSSLAITHQDKIVLKPENISFNEAAAVCVVYATSYYSIFHIGAFMADKESILVHSATGGVGLATLNLLKWKRNQLKKHGNSEISNDASIYATVGSKEKVDYLQEKYGDLITAIYNSRDTEYCDEIKQQSAQGGVDLILNTLSGDYLSANFRSLSQVGRIMDLSVTQLVENDSLDFSNFKYHVTYSTIDLERATTYNSKIVRDILTEVFDAISDGSLENIPVKVFPATQVKTAIEYINERVHIGKIVVDFENFEQDILKPALQEKENPIQLNKVKKLEHTCDTLNNTILITGQTGIAVHILKWIISGSVLNSNKSQQQVTDFIILSRSSLKWELENLINQTKHKYGDRFRFHYKSVNIADLNSTRTAIDQVYSSCKNVSPIKSVLHFATVYEYILPEDITQTVIDNTHNPKAVGAINLHNLSIEKDWKLENFILFSSIGAIIGGSKQCAYSSANLVLDSLSNYRKSIGLASTSINWGGLDAGGVAATDKSVASFLEGQGILLVSLSKILGCLDSVFQPSNSHLSNFMLSSFNIDNLLSSAPQMKRKMGHHLTNYKTSSASSDDSLGDSSSTQAKVISTISELLSIHPSKLNLDTRLKDYGIDSLLTVQLKNWIDKEFTKNLFTHLQLSSSSINSIIQRISSKSTSTSTPNPTNTTKQTATTKT
What is the function of this protein?
Probable polyketide synthase.
What are the official names of this protein?
Probable polyketide synthase 16, dipks16.
Protein: CTGE1_HUMAN
Sequence: MFVIISLHNCVVISFVLFLFGGNNFIQNFYLPQNYIDQFLLTSFPTFTSVGVLIVLVLCSAFLLLWQGEGVNLR
What are the official names of this protein?
Cutaneous T-cell lymphoma-associated antigen 1, Protein cTAGE-1, Cancer/testis antigen 21.1, CT21.1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EZRI_RABIT
Sequence: MPKPINVRVTTMDAELEFAVQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVSEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYSKEAHKAGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKNDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLESEKKRREAVEQEKEQMLREKEELMMRLQDYEQKTKKAEKELSDQIQRALQLEDERKRAQEESERLEADRVAALRAKEELERQAADQIKSQEQLAAELAEYTAKIALLEEARRRKESEVEEWQHRAREAQDDLVKTKEELHLVMTAPPPPPPPMYEPVSYHVQEHLHEEGAESLGYSAELSSEGILDDRHEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENLRQGRDKYKTLRQIRQGNTKQRIDEFEAM
What is the function of this protein?
Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity).  In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.  Along with PLEKHG6, required for normal macropinocytosis (By similarity).
What are the official names of this protein?
Ezrin, Cytovillin, Villin-2, p81.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). Localization to the apical membrane of parietal cells depends on the interaction with PALS1.
Protein: HIS6_BACC4
Sequence: MLAKRIIPCLDVKEGRVVKGVNFIGLQDVGDPVEIAEAYNVAGADEIVFLDITATHEGRKTIIDVVEKTAAKVFIPLTVGGGISSVKDMYNLLRAGADKVSINSAAVRNPKLIEEGAEHFGSQCIVVAIDARKVAEDKWNVYVNGGRVDTGMDAIEWANRVVKLGAGEILLTSMDADGTKSGYDLRLTEEISKSVSIPVIASGGCGHTDHIIEVFQKTTVDAALAASIFHYGEATVHSVKRKLRDANIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_ACTSZ
Sequence: MPRRRRIEPRKILPDPKFGSELLAKFINVLMVDGKKSIAESIVYNALETLAQRTGKDALESFEIALENVRPTVEVKSRRVGGSTYQVPVEVRPTRRNALGMRWIVEAARKRGDKSMALRLANELSDAVDNKGAAVKKREDVHRMAEANKAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ATM1_CRYNB
Sequence: MSFGSCSRHALFTPGALPGSFRTMTTSCVKRVYTAQIRGGDALGKRLPSVSSFPGQLPRHGSHFQSLAFFSTSRRRQTPPPPSPPTTSQSPTVPSKASTTPPTSLNTSKPVATESQDKTDWSIIAKLAGNIWPKNNPNVKFRVIGALTLLVAGKVLNVQVPFFFKTIVDSLNVPITESTTVWVLAGASIAGYGAARVLTTLFGELRNAVFASVAQNAIRKVARETFEHLLNMDMKFHLERQTGGLTRAIDRGTKGISFILSSIVFHVIPTALEISMVCGILSWKFGWDFAAVTAITMLLYTWFTIKTTAWRTTFRKQANAADNKGATVAVDSLINYEAVKSFNNEKYEVAQYDTTLKAYEKASVKIATSLAALNSGQNFIFSSALTMMMLLGAQGIVKGTMTVGDLVLVNQLVFQLSLPLNFLGTVYRELRQSLIDMDVMFNLQSLDSATKDSPTAKPLHLKGGEIEFRNVAFAYHPERPIFRDLSFKIPAGQKVAIVGPSGCGKSTVFRLLFRFYDSSSGQILIDGQDIKTVTLDSLRRSIGVVPQDTPLFHADILHNIRYGNLEATDEQVYEAARKAHVEGTIQRLPEKYATKVGERGLMISGGEKQRLAVARVLLKDPPVLFFDEATSALDVYTETELMRNINSILTGQGKTSVFIAHRLRTISDADLIIVLQDGYVAEQGTHEQLLAMPGGVYHGLWQAQLTESTQPTEEEIERQREELEIVDEKKKQQT
What is the function of this protein?
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity).  Hydrolyzes ATP (By similarity).  Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).
What are the official names of this protein?
Iron-sulfur clusters transporter ATM1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TAL_VIBC3
Sequence: MSNKLAQLRKLTTVVADTGEIDAIKKYQPEDATTNPSLILKAAQIAEYAPLIDQAIAYAKTQSNDKAQQVQDTCDMLAVNIGKEILKTIPGRISTEVDARLSYDMERSVAKARQLVKMYNDAGISNDRILIKLASTWEGIRAAEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRIMDWYKAKEGRDFAASEDPGVLSVTKIYNYYKEHGYKTVVMGASFRNIGEILELAGCDRLTIAPSLLAELEAAEGELVAKLVDSKGSKARPAPMTHSEFLWEHNLDAMAVEKLAEGIRNFAVDQGKLEAMIAAKL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA235_MICAT
Sequence: MNPAHLLVLAAVCISLSGASSIAPQPLNLIQFGNMIQCTIPGSSPLLDYADYGCYCGRGGSGTPVDKLDRCCQAHDKCYTDAYRFYRCWPFLTLYSHTCSNRKVICRGNTTKCKAFVCNCDRVAANCFAKAPYNKRNYNNCK
What is the function of this protein?
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 MALT0035C, svPLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_SHELP
Sequence: MAAMTVQLDIVSAESSIFSGLVAHLQVSGAEGDLGVMPGHAPLLTHIKPGMARIVKQDGKEEVFYLSGGILEVQPFSVSVLADVVLRAEEIDEQAAVEAKRRAEAHMANAGADFNYAAAAIELAQAIAQLRVVETIKKNIAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: C5AR1_RABIT
Sequence: APMENSTYDYTNYDSLGTLDPSTPVDNTVRRLRPTTIVALVIYMAVFLVGVPGNALVVWVTALEAKRTVNAIWFLNLAVADLLSCLALPILFVSIIQEGHWPFGRAACSVLPSLILLNMYASILLLATISADRFLLVFNPIWCQNTRGAGLAWLACCVAWGLALLLTIPSFLYRKVLQDDYPPKTTCGVDYGHEGVRAERAVAIVRLVVGFLLPLFTLSVCYTFLLLRTWSRNGTRSTKTLKVVVAVVVSFFIFWLPYQVMGMILALLHPSSATFRWAIRLDPLCIALAYVNCCINPIIYVVAGKGFQGQLRKSLPSLLRNVLAEESVIQGSKSFSRSTVDTVADKCQAV
What is the function of this protein?
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10510441).  The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.  Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
What are the official names of this protein?
C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Protein: YCF12_SYNJA
Sequence: MFGQYEVFVQLLLLALIVLAGPAVILLLYLRGADM
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RCAN3_CHICK
Sequence: MLRDTMKSWSDSQSDLYSSDQEEEEQMIFGENEDDFEEMMDLSDLPTSLFACSVHEAVFEVQEEKERFEALFTVYDNQVTFQLFKSFRRVRINFSNPEAAARARIELHETDFSGKKLKLYFAQVQVSSEVGDKSYLLPPQPVKQFLISPPASPPVGWKQSEDATPLINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEEIKNPKQKIMQTRRPEPPATILNESKAFDCTLEVGGTIHC
What is the function of this protein?
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.  Could play a role during central nervous system development (By similarity).
What are the official names of this protein?
Calcipressin-3, Regulator of calcineurin 3.
What is the protein family that this protein belongs to?
Belongs to the RCAN family.
Protein: CAPG_HUMAN
Sequence: MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDWK
What is the function of this protein?
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments.  May play an important role in macrophage function.  May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin.  May bind DNA.
What are the official names of this protein?
Macrophage-capping protein, Actin regulatory protein CAP-G.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia.
Protein: SUMO3_BOVIN
Sequence: MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSRVASCLLGSGL
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process.  Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.  Plays a role in the regulation of sumoylation status of SETX (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 3, SUMO-3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body.
Protein: COFC_METM6
Sequence: MLAALIPVSPLSNVKSRLKEFLSSDERIELIKNILIDTYETVKECSDACYVVSKDEEILEFSKNLGIIPIRENSSVKGLNEAINFSLKFIKEDSILITPADVPILKEENLKVITNKSVKNSIVICPSRGGGTNLLLLNPKDCMKTQFEGFSFLKHIEEAEKNNLKVIKCHSFYTSIDVNTVEDLGEIYIHGTDTKTYQFLKNLGIEVLPKHSSAGRFNVIRK
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: EF1A1_RAT
Sequence: MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGSASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.  Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
What are the official names of this protein?
Elongation factor 1-alpha 1, EF-1-alpha-1, Elongation factor Tu, EF-Tu, Eukaryotic elongation factor 1 A-1, eEF1A-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Note=Colocalizes with DLC1 at actin- rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens. Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B.
Protein: PHP_MYCTO
Sequence: MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDEDKRVAGAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLYTYNDVPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCATDEPGLTPGVERVLRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGVDLSRVVIGHCGDSTDVGYLEELIAAGSYLGMDRFGVDVISPFQDRVNIVARMCERGHADKMVLSHDACCYFDALPEELVPVAMPNWHYLHIHNDVIPALKQHGVTDEQLHTMLVDNPRRIFERQGGYQ
What are the official names of this protein?
Phosphotriesterase homology protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
Protein: HKM12_ASPHA
Sequence: MLSKYQPSAHIAVTRAHWEDLHQAISSGKVTIDGNSLTLADVVAVSKFGCYARLSENRETIDAINESVSTLQECLDEGHHIYGVNTGFGGSADSRTDHLASLQRALLQLLQSGILTKADIGSGDTPSQSHAMPPEWVKAIMVVRSNSVARGHSAVSIGSIEAILRLLQRDITPVVPLRGTISASGDLMPLAYIVGAIEGNPGVFARAGKSPHGQALPAQQVLEQLGIPRITLGPKEALGLVNGTAASAALSSLVLYEAHRLALLSQVTTALTVEALRGSAESFHPFISQARPHDGQMEAASNILTVMRGSRLAMGTSEVQTGLVQDRYSLRTASQWIGPQLEDLLLADRQITVELNSTTDNPLIDSVSRHFYCGGNFQATSVTSAMEKTRLALQMLGKLMFAQCSEMIDPSLNNGLPTNLVADDPSLSFTMKGVDISMAAYMSELAYLANPVSSHVQTAEMHNQAVNSLAFVSARYTMQAVDIVSMMSACSLYVACQALDLRVLQLNFFRELHPIVCNGTHDAFHTILAPKELERITQQLVTAIQDAWLTTSRMDAGDRCQRVIKLSLPILLNEMRGAIPSDRQQVDLLTSIGNWEEATCYKMLEAYKQTHERFCRTQNTVEYLGAGSKAIYHAIRHKVGVPFHQGFVEQPSADDLDTTAIINGREKKTTGGWISLIYEALRDDSLTGVILEAVQPVRSI
What is the function of this protein?
Phenylalanine ammonia-lyase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines (PubMed:33242032).  The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable).  Xenocockiamide A is then converted to hancockiamide D via a series of hydroxylations and O-methylations (Probable).  The tyrosinase hkm6 may catalyze an aromatic hydroxylation, then the 2-oxoglutarate-dependent Fe(II) dioxygenase hkm4 and the FAD-dependent phenol hydroxylase hkm7 may catalyze consecutive hydroxylations to install 2 more hydroxy groups, and the methyltransferase hkm8 probably catalyzes two methylations using 2 molecules of S-adenosyl-L-methionine (SAM) (Probable).  The NRPS hkm11 activates and transfers trans-cinnamate supplied by the PAL hkm12 to hancockiamide D and produces hancockiamide A (PubMed:33242032).  NRPS Hkm11 has the flexibility to tolerate the bulky hancockiamide G as a substrate and the absence of the acetyl-transferase hkm3 opens up the opportunity for hkm11 to introduce a second N-cinnamoyl moiety (PubMed:33242032).  The cytochrome P450 monooxygenase hkm5 catalyzes the methylenedioxy bridge formation, converting hancockiamide A into hancockiamide G (PubMed:33242032).  Hkm5 can also convert hancockiamide B into hancockiamide C, and hancockiamide D into hancockiamide H (PubMed:33242032).  The N-acetyltransferase hkm3 finally transfers an acetyl group to 1-N of piperazine, converting hancockiamide A into hancockiamide B and hancockiamide G into hancockiamide C (PubMed:33242032).
What are the official names of this protein?
Phenylalanine ammonia-lyase hkm12, PAL, Hancockiamides biosynthesis cluster protein 12.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
Protein: UVRC_XYLF2
Sequence: MTDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRLTAMLAQVVRMDVTITRNEAEALLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIALHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSAPCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLRSMQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILSAFVSQYYAEYPPPPEILLDQEIPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRNAQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDISHTMGEATVASCVVFDAVGPVRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKMALNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAITGHRARRQKTRMTSKLEDIPGIGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAAKIYASLHGLSKNDAANASRVS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_VIBPA
Sequence: MTQPIKLLVGLANPGPEYAKTRHNAGAWVVEELARVHNVTLKNEPKFFGLTGRIMVNGQDLRLLIPTTFMNLSGKAIAALAKFYQIKPEEIMVAHDELDLPPGVAKFKKGGGHGGHNGLRDTISKLGNNKDFYRLRIGIGHPGHKDKVAGFVLGKAPAKEQELLDAAADEAVRSLDILIKDGLSKAQNRLHTFKAE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_ECODH
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_BRUO2
Sequence: MGLTGTNTTLVAPQPKGILDPRTGKPVGSDDAFFNDLNGELSDKGFIVTSADALITWARTGSLMWMTFGLACCAVEMMHISMPRYDAERFGIAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPTAEALLYGILLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METJ_KLEP7
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPNDEDLRKERSDEIPEAAKAIMRELGIDPDTWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.