PharMolix/UniProtQA huggingface dataset:
Protein: KGP66_PORGN
Sequence: MRKLLLLIAASLLGVGLYAQNAKIKLDAPTTRTTCTNNSFKQFDASFSFNEVELTKVETKGGTFASVSIPGAFPTGEVGSPEVPAVRKLIAVPVGATPVVRVKSFTEQVYSLNQYGSEKLMPHQPSMSKSDDPEKVPFAYNAAAYARKGFVGQELTQVEMLGTMRGVRIAALTINPVQYDVVANQLKVRNNIEIEVSFQGADEVATQRLYDASFSPYFETAYKQLFNRDVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSVTATQVKALTNKNKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAENIGNVTHIGAHYYWEAYHVLGDGSVMPYRAMPKTNTYTLPASLPQNQASYSIQASAGSYVAISKDGVLYGTGVANASGVATVNMTKQITENGNYDVVITRSNYLPVIKQIQAGEPSPYQPVSNLTATTQGQKVTLKWDAPSAKKAEGSREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIKEGLTATTFEEDGVAAGNHEYCVEVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKVTLKWDAPNGTPNPNPNPNPGTTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKGVRSPEAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANGKRADFTETFESSTHGEAPAEWTTIDADGDGQGWLCLSSGQLDWLTAHGGTNVVASFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEADGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKKCVNVTINPTQFNPVKNLKAQPDGGDVVLKWEAPSAKKAEGSREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIKEGLTETTYRDAGMSAQSHEYCVEVKYAAGVSPKVCVDYIPDGVADVTAQKPYTLTVVGKTITVTCQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEKLAVK
What is the function of this protein?
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position (PubMed:8999833).  Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG.  Disrupts the functions of polymorphonuclear leukocytes.  May act as a virulence factor in the development of peridontal disease.  Involved in the coaggregation of P. gingivalis with other oral bacteria (By similarity).
What are the official names of this protein?
Lys-gingipain HG66.
What is the protein family that this protein belongs to?
Belongs to the peptidase C25 family.
What are the subcellular locations of this protein?
[Lys-gingipain catalytic subunit]: Secreted.
Protein: SOML2_SPAAU
Sequence: MRMMRAIKQGQWAILLWPYLLTTSIPLDCRDEQGGLSRCPSISQEKLLDRVIQHAELIYRVSEESCSLFEEMFIPFPLQLQRNQAGYPCITKALPIPSSKSEIQQISDKWLLHSVLMLVQSWIEPLVYLQTTLNRYDGVPDMLLNKTKWVSDKLMSLEQGVAVLIKKMLDEGLMTTTYSEQGLFQDDGQPEMLEYVMRDYTLLSCFKKDAHKMEILLKLLKCRQNDIHSCA
What are the official names of this protein?
Somatolactin-2, SL.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPRG_MYCTO
Sequence: MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS
What is the function of this protein?
Constitutes a host TLR2 agonist (toll-like receptor).
What are the official names of this protein?
Lipoarabinomannan carrier protein LprG, 27 kDa lipoprotein, Antigen P27, Lipoprotein LprG, Triacylglyceride transfer protein LprG.
What is the protein family that this protein belongs to?
Belongs to the LppX/LprAFG lipoprotein family.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor. Secreted, cell wall. Secreted.
Protein: HBA2_BUBBU
Sequence: MVLSAADKSNIQAAWGKVGGHAADYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVANALTKAVGHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPNDFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-2, Alpha-2-globin, Hemoglobin alpha-2 chain, Ialpha2.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TRMA_PSYIN
Sequence: MTLQFVDPENYETLLAAKKEHLNKQFAIFNPPALECFASPKLHYRMRAELRVWHDGDELYYIMFDKKTKQKFRVEQFPPASELINNLMPVLLELVKSSEILRYKLFQIDFLSNLKGQVIVSLLYHKQLDDNWLVEAKRIKAELLKQFDINFIGRARKQKILLDYDYVIEELQVDGNKLFYQQIENSFTQPNAKVCEKMLEWAIDCTRDSQGDLLELYCGNGNFSLALAKNFNKVLATEIAKPSVESAQFNMAQNGINNVTVIRMSAEEFTQAINGEREFYRLKEITLSDYQCNTILVDPPRSGLDDETVKMVQHYDNILYISCNADTLSRNLEVLSKTHEIKRFALFDQFPYTYHSEAGVYLVKR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: FLPA_METMP
Sequence: MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLGAAIINGLKKMPIKKGEKVLYLGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEILVKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: APOL5_HUMAN
Sequence: MPCGKQGNLQVPGSKVLPGLGEGCKEMWLRKVIYGGEVWGKSPEPEFPSLVNLCQSWKINNLMSTVHSDEAGMLSYFLFEELMRCDKDSMPDGNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVDTTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGPLTTSHEAFGGINWSEIEAAGFCVNKCVKAIQGIKDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEGTTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQHHRHLPQKASQTCSSSRGRAVRGSRVVKPEGSRSPLPWPVVEHQPRLGPGVALRTPKRTVSAPRMLGHQPAPPAPARKGRQAPGRHRQ
What is the function of this protein?
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
What are the official names of this protein?
Apolipoprotein L5, Apolipoprotein L-V, ApoL-V.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROV_ECOLI
Sequence: MAIKLEIKNLYKIFGEHPQRAFKYIEQGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRTPNGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQQQGLDAALIDAPLAVDAQTPLSELLSHVGQAPCAVPVVDEDQQYVGIISKGMLLRALDREGVNNG
What is the function of this protein?
Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake (PubMed:3305496, PubMed:7898450, PubMed:23249124).  Probably responsible for energy coupling to the transport system (Probable).
What are the official names of this protein?
Glycine betaine/proline betaine transport system ATP-binding protein ProV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPOZ_SHEB2
Sequence: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQTVREREAAEIAAVSAIAEGRSL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: NLTP3_VITSX
Sequence: LSCGDVATQMASCINYLRGAGPLPAACCNGVKNLKNSATTTQDRRTACKCLISASKTISGVNFGLAAGLPAKCGVSIPYKISPSTNCDQVN
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein P3, LTP P3.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL44_OCHTR
Sequence: MVNVPKQRRTYCKKCKVHRVHKVTQYKKSKERKASQGRRRYDRKQKGFGGQTKPIFRKKAKTTKKIVLRMECVDCKYRKQTPLKRCKHFELGGDKKRKGQMIQF
What are the official names of this protein?
60S ribosomal protein L44.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
Protein: APY4_ARATH
Sequence: MQRSNARSRSNINSDMVDPPEVQTSPGNHRSSPSTAAKPKSKRTKSIIFVIVACVTIALGLLFIGYSILRSGRNRRVSLHYSVIIDGGSSGTRVHVFGYRIESGKPVFDFGEENYASLKLSPGLSAYADNPEGVSESVTELVEFAKKRVHKGKLKKSDIRLMATAGMRLLELPVQEQILDVTRRVLRSSGFDFRDEWASVISGSDEGVYAWVVANHALGSLGGEPLKTTGIVELGGASAQVTFVSTELVPSEFSRTLAYGNVSYNLYSHSFLDFGQDAAQEKLSESLYNSAANSTGEGIVPDPCIPKGYILETNLQKDLPGFLADKGKFTATLQAAGNFSECRSAAFAMLQEEKGKCTYKRCSIGSIFTPNLQGSFLATENFFHTSKFFGLGEKEWLSEMILAGKRFCGEEWSKLKVKYPTFKDENLLRYCFSSAYIISMLHDSLGVALDDERIKYASKAGEEDIPLDWALGAFILNTATATFDYSGKSRKILDLSNVAKYKI
What is the function of this protein?
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.
What are the official names of this protein?
Probable apyrase 4, AtAPY4, ATP-diphosphatase, ATP-diphosphohydrolase, Adenosine diphosphatase, ADPase, NTPDase, Nucleoside triphosphate diphosphohydrolase 4.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: PYREL_METM5
Sequence: MKKELILKALKLRDMGFPSGDIAEELNISVKTALYLTLNGEELLKAGETPKEDSEKLDIFLEWDNVRASSRRLRNISKIICDMLSDVEFDGIVGISSGGVPLATLISDELDKNFSIYVPKKHVHTEKEKTTGFIGQNMSSIVGKDVIIVDDVMTSGNSVKETIKYLKGIANPKKVFVVMDKSGIDEIDGVKIEHLFRTGVVDIKK
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: PILA_MYXXD
Sequence: MRVSRFNPRNRGFTLIELMIVVAIIGILAAIAIPNFIKFQARSKQSEAKTNLKALYTAQKSFFSEKDRYSDFANEIGFAPERGNRYGYRVSAAAGDCEVRNAADLPVPAAGVPCISNDSFRFGANSAIDDPTPVVARFVPQGAAGWNTTLGVQPTIADCPNCNFFAGARGNADNEATFDDWVIAGFEGSGQVGPCSEAGNVASGTPYNTRNDVACDGAAQ
What is the function of this protein?
Major component of the type IV pili that are required for social gliding motility through cycles of extension and retraction.  Extended pili are composed of thousands of copies of PilA and retract upon binding to extracellular polysaccharides and thereby pull the cell forward.
What are the official names of this protein?
Type IV major pilin protein PilA, Pilin.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: HSLU_YERPN
Sequence: MSEMTPREIVSELDSHIIGQDKAKRAVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRHQSIEKMRYRAEELAEERILDVLIPPAKNNWGVPDESQEPSATRQTFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTNQLQSMFQNIAGQKQKPRKIKIKEALKLLIEEEAAKLVNPEELKQQAIDAVEQHGIVFIDEIDKICKRGQTSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVSSPSDLIPELQGRLPIRVELQALTTDDFERILTEPSASLTEQYKALMATEGVTIEFTREGIRKIAEAAWQVNERTENIGARRLHTVLERLMEDISYDASESSGQSITIDAEYVGKHLDELVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_ACIB3
Sequence: MQVYLVGGAVRDYLLGHPYQEKDYVVVGATPEHMLAQGFQPVGKDFPVFLHPETKEEYALARTERKSGQGYHGFQFFTDTTVSLEDDLIRRDLTINAIAMDQDGKIYDPYGGQNDLENKILRHVSEAFAEDPLRVLRVARFAARYFPYGFQIAPETLQLMQTMADSGELDALTPERVWKETSRALMENHADIYFQTLRDCGALKHLFPEIDALFGVPQRPEYHPEVDCGIHTLMSLQQACKSNYSLDVRFAVLVHDLGKALTPAEELPRHIMHEERGIKPVTQLCERLRVPTQTKQLALSVCKEHLKCHQIMSLKPGTLWRLLQRLDVLRRPERVEAFVQACECDAKGRLGLEDRPYPQAQYMREAMQIVRSIKVQDLPENIKGAEIGEMLIQYRIEALAEFKNQHQSLSHS
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: RL18_ARCFU
Sequence: MKLARGPRYKVPLRRRREGKTNYRKRLKLLLSRKPRLVVRITNRRVIAQIVEYAPEGDRVVVGVDSAMLREFGWKGDLNNTPAAYLTGILIAKKALQKGIGEAVLDIGLHTPTRGSRVFAVLRGAVEGGLEVPHSDEVLPDDSRIRGEHIAAYYEMNPERFGEYEKRGLKPSDLPAHVDEIKEKLMVIS
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RS9_META3
Sequence: MKVVHTVGKRKTAIARATAKEGKGRIRINKKPIEIVEPKYINAKLMEPIILAGDVVDGIDIDITVNGGGIVGQMDAARTALGKAIVEFTGDMELKDRFVHYDRTILISDARRTEPHKPSKSTKGPRAKRQKSYR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: Y1142_NATTJ
Sequence: MTWKQNETEIRQRIKEGQYDGPTTGLMNGFTQANLVILPQNLAYDFLLFCQRNPKPCPLLEVIDTGKYEPKETAPGKDLRTDLPRYYIYRDGVKSAEVTDINKYWTQDLVSFLLGCSFTFESFFLQRGVPVRHIEEGVNVPMYRTNIKCKDAGVFHGNMVVSMRPIPENKLTEAIQITSRFPAVHGAPIHIGSPEKIGIKDLDSPDFGNRVNVESGEIPVFWACGVTPQAVIMNYRPEFVITHAPGHMFITDKKDMDYFQL
What are the official names of this protein?
Putative hydro-lyase Nther_1142.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: FBD15_ARATH
Sequence: MPGFDRISELPESLITQILLCLPTKDSVKTSVLSTRWKNLWLNVPGLDLTCSDFPFEDEEYEQVFINFIDRFLEFNPESRLQTFEVDYKRREIRGFKDRIGTAINRGIRLLDAVSSTMYWEEECIMYPYLEFMPLNLFTSKTLVTLKLRDSALNDPGLLSMPCLKFMILREVRWSGTMSLEKLVSGCPVLEDLTLVRTLICHIDDDELPVTRVRSRSLKTFYVPLAYGVGCRSRVPDKVLEIDAPGLENMTLKEDHFDGIVVKNLTSLFMIELNIKFAVDYRRSFDPEDLSKRNEIGDFLTGISRARHMIISQKTVKALESYSKVGSIPKFNNLSHLKAVFPSPLLPFLPAFLESFPNLKNLILKIAFAKDDETEELNLINVPRCIVSTLECVEIKGLFEWEEEEMKIARYFLENAAVLKKLTMSFIDYPRYASNSDVYEDLDKLTKRSQQCRIIVDDE
What are the official names of this protein?
FBD-associated F-box protein At5g27750.
Protein: MTNB_DROAN
Sequence: MSLSIFKDLPEEHPRHLIPSLCRQFYHLGWVTGTGGGMSIKHNDEIYIAPSGVQKERMQPEDLFVQDITGKDLQLPPEIRGLKKSQCTPLFMLAYQHRGAGAVIHTHSQHAVMATLLWPGKTFRCTHLEMIKGVYDEADKRYLRYDEELVVPIIENTPFERDLADSMYAAMMEYPGCSAILVRRHGVYVWGQTWEKAKTMSECYDYLFSIAVEMKKAGIDPEKFEST
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Probable methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_KLEP3
Sequence: MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGAVAHKVLDVTLLNELAVSSLTRDNIPVPDYQPDAEGIPNTFVPGRNILFLTLTAIYAYQVKAEAIITGVCETDFSGYPDCRDEFVKALHHAVSLGMAKDIRFETPLMWLNKAETWALADFWGQLDLVRQETLTCYNGIKGDGCGQCAACNLRANGLNQYLGDKVGVMAVMKQKTGLAQA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RPOC_PSEPU
Sequence: MKDLLNLLKNQGQVEEFDAIRIGLASPEMIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVALGKVAAERMGHIELACGLAHIWFLKSLPSRIGLLMDMTLRDIERVLYFESYVVIDPGMTTLEKGQLLNDEQYFEALEEFGDDFDAAMGAEAVRELLHAIDLEHEIGPLREEIPQTNSETKIKKLSKRLKLMEAFQGIGNLPEWMVLTVLPVVPAPLGPLVPLDGGRFATSDLNDLYRRVINRNNRLKRQLDLSAPDIIVRNEKPMLQEAVEPLLDNGACGVAIIGSNKRPLKSLADMIKGKQGLFRQNLLGKRVDYSGRSVISVGPTLRLHQCGLPKKMALELFKPFIFGKLEMRGLATTIKAAKKMVERELPEVWDVLAEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCARYNADFDGDQMAVDVPLTLEAQLENGALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREAINAKGEGRVFADLQEVDRVFRAGEAALHAKIKVRINETVKERDGSVVKNTRIVDTTVGRALLFQVVPGGLPYDVVNQPMKKKAISKLINQCYRVVGLKETVIFADQLMYTGFAYSTISGVSIGVNDFVIPDEKARIIGNATDEVKEIESQYASGLVTQGEKYNKVIDLWSKANDEVSKAMMANLSKEKVIDREGKEVEQESFNSMYMMADSGAGGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLSVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEIDCGTDQGLVMTPHIEGGDVVEPLGERVLGRVIARDVFKPGTEDVIVPAGTLVDEQWVEFIELNSIDEVIVRSPINCETRYGICAKCYGRDLARGHQVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRTSAADSVQVKNGGMGASRNLKQVERADGNLVAVSRSGELAIADEFGRECEYKLPYGAVISVKEGEKVEAGAIVAKWDPHTHPIVTELKGTVTFVGMEENITIKRQTDELTGLTNIEVLDVKDRPAARRHTLRPAIKMVDAAGKDLYLPGTDVPAQYFLPANALVGVADGAQIGVGDVIARIPQETSKTRDITGGLPRVADLFEARRPKEASILAEVSGTIAFGKETKGKRRLVITPTDGSEPYEELIPKWRHLNVFEGEQVNRGEVISDGPSDPDDILRLLGVSALGKYIDNEIQDVYRLQGVKINDKHIETILRQMLRKVRISESGDSSFIKGDQMEYPGAGRERASASEDKFISKFTRVLLGITKASLSTESFISAASFQETTRVLTEAAVTGKRDYLRGLKENVVVGRLIPAGTGLAYHTERMARRDADKPLRVSASEVEAALTEALNSSGN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PTH2_DICDI
Sequence: MQLNKDILLVSIISLFSGVLLGYFQAKCFKRSTITKNKEEVEQIKEIENNNQKEKEKEEKEGDDDDDDDDESESIDGDYDENDDYEIEYDEEIGDCKQVLVIRTDLGMTKGKIIAQCCHASLGARQKALKDSKKVLRQWENFGCAKITLKANSKEELVDLRNKAKELGVVSYLVLDSGHTQIPSGSATVLAVGPAPKEAVDAVTKHLKLY
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Probable peptidyl-tRNA hydrolase 2, PTH 2.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
Protein: TBX21_MOUSE
Sequence: MGIVEPGCGDMLTGTEPMPSDEGRGPGADQQHRFFYPEPGAQDPTDRRAGSSLGTPYSGGALVPAAPGRFLGSFAYPPRAQVAGFPGPGEFFPPPAGAEGYPPVDGYPAPDPRAGLYPGPREDYALPAGLEVSGKLRVALSNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACSASNTHVFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYASVDTSVPSPPGPNCQLLGGDPFSPLLSNQYPVPSRFYPDLPGQPKDMISQPYWLGTPREHSYEAEFRAVSMKPTLLPSAPGPTVPYYRGQDVLAPGAGWPVAPQYPPKMSPAGWFRPMRTLPMDPGLGSSEEQGSSPSLWPEVTSLQPEPSDSGLGEGDTKRRRISPYPSSGDSSSPAGAPSPFDKETEGQFYNYFPN
What is the function of this protein?
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs.  Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3.  Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (PubMed:10761931, PubMed:17923685, PubMed:21095589).  Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648).  Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC (PubMed:21151104).  Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2 (PubMed:15662016, PubMed:21690296, PubMed:23616576).  Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN- stimulated genes (PubMed:28623086).  Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (PubMed:27430722).
What are the official names of this protein?
T-box transcription factor TBX21, T-box protein 21, T-cell-specific T-box transcription factor T-bet, Transcription factor TBLYM.
What are the subcellular locations of this protein?
Nucleus.
Protein: DF258_ARATH
Sequence: MINVSLKRSLLIFISVITSNIGSEARELTGAGKKLEVATRSSNYAGTARTLLQARPCQRDVDCNFQCPRIQGGQCNNHHGTCDCF
What are the official names of this protein?
Putative defensin-like protein 258.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNME_BACC1
Sequence: MEFDTIAAISTALGEGAIAIVRVSGDDAVEKVNRIFKGKDLTEVPSHTIHYGHIVDLDTNQVIEEVMVSIMRAPRTFTRENIVEINCHGGLVSVNKVLQLILAQGVRLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAINQMEGRLSKLIGRLRQDILETLAHVEVNIDYPEYDDVEEMTHNILIEKATHVRAEIAKILETSKQGKILREGIATAIIGRPNVGKSSLLNSLVQEKKAIVTDIAGTTRDVIEEYVNVRGVPLKLIDTAGIRETEDVVERIGVERSKEMMSQADLVLVVVNYSEALTNEDEDLFRAVQGKDFIVIVNKTDLPQAIDMERVIELAAGNRIITTSLIEEQGIDELETAIADLFFEGTIDSADVTYVSNARHIGLLTQAGKTIGDAIEAIENGVPIDMVQIDLTRTWEILGEITGDTVHESLIDQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.