PharMolix/UniProtQA huggingface dataset:
Protein: URE3_STRTD
Sequence: MQLTMREQEKMMISLAAMIAQRRKDKGIKLNHPEAVALITDYVLEGAREGKTVAQLMDEARNLLTREDVMEGIAEMIPMIQVEATFTDSTKLVTVHDPIQ
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y040_GLOVI
Sequence: MGIDKRAEATAKDVQGKAQEAWGDLTDDPKLELEGKAKQVEASAEHKKEDLKDQAHRTIDNV
What are the official names of this protein?
UPF0337 protein gsr0040.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: V26BB_XENLA
Sequence: MSFFGFGPAAELDIALTDGESRRRVEHKTEDGKKEKYFLFYDGETVSGRVTVSLRNPGKRLEHQGLKIEFIGQIELYYDRGNHHEFVSLVKDLARPGELSQSQSFDFEFTHVEKPYESYTGQNVKLRYFLRATLSRRLNDVAKEMDIVVYTLSTYPELNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEIVLWRKGDIVRKSMSHQAAIASQRFEGTSHPETRPQHSGAAALEQEHE
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26B-B, Vesicle protein sorting 26B-B.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Endosome.
Protein: LIPB_SYNPW
Sequence: MPRPIGNLETTTDSGTGSAAFLFQPAHLVPFVQAWTWQRLWQERLLKGADSGGDPPPEAVWLLQHPPCYTLGRGASEDHLLFDPEHPPAPLHRIDRGGEVTHHAPGQLVIYPVLDLHRHRTDLHWYLRQLEQVVIDVLAALGLRGERIEGLTGVWLDQCKVAAIGVGCRRWITQHGVALNVNCALEGFESVVPCGLAGRAVGCLSDWCPGLHVSEVQPLVCDALAARFGLCLEPNADAAIAEGRCW
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y04J_BPT4
Sequence: MDYAIKPWWAARWETVEPEPEEPVYTDEETVYNEPTINDLIDMEMGHDYSR
What are the official names of this protein?
Uncharacterized 6.2 kDa protein in pin-nrdC intergenic region.
Protein: URE2_ACIBS
Sequence: MIPGEVITPETDIELNVGRETLKVVVANLGDRPIQVGSHFHFYEANDALQFDREVAKGFRLNIAAGTAIRFEPGQSREVELVALAGKREVYGFAGRVMGRLYENVD
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_ECOHS
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_MYCA9
Sequence: MKPGIHPDYHPVVFQDTTTGKMFLTRSTATSTRTVEWEGKEYPLITAEVTADSHPFWTGDRRIVDSAGQVEKFRRRYGTR
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: MUTL_STAES
Sequence: MGKIKELETSLANKIAAGEVVERPSSVVKELLENAIDAQATEINIEVEQSGVSSIRVVDNGTGIAQEDLGLVFHRHATSKIVADDDLFHIRTLGFRGEALASISSVAKVTLKTCTDNENGHEIYAENGKIIHQKPAKAKKGTDIQVDSLFYNTPARLKYIKSLYTELGKITDIVNRMAMSHPEIRISLVSDGKKLLSTNGSGRTNEVMAEIYGMKVAKDLVHISGDTSDYHLEGFVAKPEHSRSNKHYISIFINGRYIKNFVLNKAILEGYHTLLTIGRFPICYINIQMDPILVDVNVHPTKLEVRLSKEDQLYDLIVTKIREAFKDKILIPQNDLNHASKKNKVLETFEQQKINFEKQQSQIGETSAPYVHDQKDKNHDVESHKNNLDSTSSTNNESTEVSNELHNHIDDSYLQSQKEVLFDMEQNTSNEYEISNQQSNDIKGTVSQTPHRRVPYMEIVGQVHGTYIIAQNENGMFMIDQHAAQERIKYEYFREKIGEVTNEVQNLLIPLTFHFSKDEQMIIDQYKDELDKVGVHLEHFGGHDYIVNSYPVWFPKEEAEEIIKDMIELVLKHKSVDVKKIREDAAIMMSCKKSIKANHYLKNNEMADLIDQLREAEDPFTCPHGRPIIINFSNYELEKLFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: IF2M_YEAST
Sequence: MLRRHGLFWLKTCPRLNVLLNQSIPIPHLLHSRDICQQRWYAKGKRRNQISKKELKPLNFSIPNYISVNKLANLLNCRVERLIKDLTALGFENITTTYILSKEYVELILQEYNFALPNLSTSTNLDNVYDELKSPVNPKLLTKRAPVVTIMGHVDHGKTTIIDYLRKSSVVAQEHGGITQHIGAFQITAPKSGKKITFLDTPGHAAFLKMRERGANITDIIVLVVSVEDSLMPQTLEAIKHAKNSGNEMIIAITKIDRIPQPKEREKKIEKVINDLIVQGIPVEKIGGDVQVIPISAKTGENMDLLEESIVLLSEVMDIRAENSPKTIAEGWIIESQVKKQVGNVATVLVKKGTLQKGKILICGNTFCKIKNLIDDKGIPILKATPSYATEVLGWKDVPHVGDEVIQVKSEAIAKKFISKRQDLIEVQKNSSIVEKLNEERALAKEQHLNKELEHENTVQEHEQNTGPKLINYIIKCDVSGSAEAVSESISSLGNDEVRCNVISSSVGIPTESDLKMAQITESTILCFNLGNLPSEVINNRAGIKIKQYNVIYKLIEDVTETLTENLKPIFEKKIVSTVDVRETFDFRLKKKIIRIAGCKVNNGVIKKNSLVQVVRGPNEDVIFDGKISTLKHNKDDVAEVSKGHECGITFESGFEGFKPGDKILVYENVRVPRYL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2, mitochondrial, IF-2(Mt), IF-2Mt, IF2(mt).
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DER_CHLPM
Sequence: MKPLIALVGRPNVGKSTLFNRILRERAAIVDSTPGVTRDRHISEGFWQGRAFRLMDTGGYAPEDGVISNAMLEQTMTAINDADIVVFVADARAGLSYDDLELAKVLRQRFSHKPVFFAVNKVESPQLAYEAASFVSTGYTEPWCISAKDGSGVADLLDAILLEMPESDADQEEDGAIRLAVVGRPNVGKSSFVNALLGNNRQIVSDIPGTTRDAIDTRFTRNQQDFLLIDTAGLRKRTKISAGIEYYSSLRSEKAIERCEVVMVMIDAGPGIEKQDLKIINMATERKRAVLLLVNKWDLIEKDSKTSKQYEDTLRSHMGNLAYVPVLFISALTKKNLYRAIDTAREIRDNRARKISTSALNRFLEEALAANPPSSKGGTELKIKYMTQIQAAWPVFAFFCNNPELVQTNFRKFLENRLREKFDLKGVTISLRFLQK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PIWL1_MOUSE
Sequence: MTGRARARARGRARGQETVQHVGAAASQQPGYIPPRPQQSPTEGDLVGRGRQRGMVVGATSKSQELQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGRCHAFDGTILFLPKRLQHKVTEVFSQTRNGEHVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRLVIWPGFTTSILQYENNIMLCTDVSHKVLRSETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKYNNKTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDWGLSFDSNLLSFSGRILQSEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQNLFKVTPAMGIQMKKAIMIEVDDRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGIDCYHDTTAGRRSIAGFVASINEGMTRWFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPSRVIVYRDGVGDGQLKTLVNYEVPQFLDCLKSVGRGYNPRLTVIVVKKRVNARFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL
What is the function of this protein?
Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:22121019, PubMed:21237665).  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:22121019, PubMed:21237665).  Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:11578866, PubMed:22121019, PubMed:21237665).  Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) (PubMed:24757166).  Not involved in the piRNA amplification loop, also named ping-pong amplification cycle (PubMed:22121019).  Acts as an endoribonuclease that cleaves transposon messenger RNAs (PubMed:22121019).  Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:16938833).  Probable component of some RISC complex, which mediates RNA cleavage and translational silencing (PubMed:16938833).  Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (PubMed:16787948).  Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1 (PubMed:28552346).
What are the official names of this protein?
Piwi-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body.
Protein: PALA_EMENI
Sequence: MASNILQIPFRRSHTVSLSTALTQYISTKYDQRPDMFADDLLIIDRLRNEAINVQEPHVSGISRLVTYAAQLKWLGGKFPVDVGVEFPWYPAFGFNTSRPVSQDNIRFELANVIFNLAALYSQLAFAVNRTTTDGLKQACNYFCQAAGILAHLRTDIVPDMRSAPPEDMDEMTLRSLEELLLAQAQECFWQKAVMDGLKDASIARLAGQVSDFYGDACDHAVKSNAISPEWIHHMTAKQHHFAAAAQYRQSLDCLEKRKYGEEVARLRDAVACVNEALKESRWINRTVLGDLQGLKNRVTEDLKRAEKDNDMIYLNPVPPKSELKLIDRACMVAAKAPSQVTDAISMLGEKGPLGQPLFSKLVPYAVHIAASIYSDRRDRLVNERIIGELENMTDKLRDLLSSLNLPGSLQALEKPLGLPPSLVAHAEEMRQQDGLNRLRKSLLDIAKVKSNDRAVYTEGVELLAAEKAEDDASRRKFGTDRWTREASEAAAPKLYTTAREIDGYFTSAQSSDNLVEQKLHDSEAVFRVLTGTNRDLEAFVPSSRRATIPPEVEREVSRLRSCISEVNRLESRRKRKAQAVKDKARADDISSALVREAARLEREFPMQAIQASQFEDLFESRLRDYDVDLDMVAQEMHDQDQIVAQVRDANRAFTRAHTGDASTKEREKALQELENGYLKYKEIISNIEVGRKFYNDLAKIVGRFRDDVKAFVHKRRMEASQLEQDISSVAAMASLNISPIRQPPQQTVVSAPVSVSAAASVPAPTHFNPVKPQPQPPSQAIPPQSQPQPQPQPLRTPLTAPQPTRSVPQVTPGMWSPEMGIRFGPGGTTAQQSQQTWDPSKGMKFS
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH.  May act as a scaffold protein that recruits the calpain-like protease palB via vps32 to its substrate pacC (By similarity).
What are the official names of this protein?
pH-response regulator protein palA/RIM20.
What is the protein family that this protein belongs to?
Belongs to the palA/RIM20 family.
Protein: SLYX_ECO7I
Sequence: MQDLSLEARLAELESRLAFQEITIEELNVTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RDRP_FXMV
Sequence: MSIEAVFDQVTDPSLRAVIQEEAHKQIKDLFKETTRCNPYSIPQAGRKVLEKYAIPYNPYSLKLHPHAASKAFEVSLYEAASNYLPSTSSTPVTFMFTKPGKLRFFRRRGHVDKFVNADIVPRDLARYPRDTVYSYLPEITTTHAFIGDTLHHFGEDFLVEVFSRSPKLEVLLATMVLPPEAFYRMESLHPSVYTLLYRDDRFLYLPGGLSGGEYEHRYKDLNWLTFGTVTHGGITITGERIETKAANHLFLFRRGRLATPKFRSFDMPEPMVLLPKVFRPAKYNVQKPIPREKANKWLMYVKSIGNATIRDVWAKLRQTIANADIGLFSPTELVHLTNYFLLLGRLDSHNSFDQVLADSVLKAWFRPMVAKLQEIKHKLMGQTQFMQLCQALEMTEVDLVFEVRDSKTPHKQAVPLDREIENVLLEGVSSEPTYTETEGVADGPLPPPMQTAAEPSATSDEPESSSSREIEHQPAPEITLDEEEPQRDDLPWDAWRTQLRALGFEASERQYDPDGELISPILSTRRLPKTPIDTTLYATLDKIARCPTFYKPDTDRAQTYARDVMAGKTGAILKQQPFEWKTTLKRKTKEEPKEIHLAVLHGAGGSGKSYALQEFMRNNSDTPITVILPTNELRADWKKKLPAHDKDTFMTYENALLCPRGDIFIMDDYTKLPRGYIEAFVQNAPALSLLILTGDPNQAEHFETTEDNEINSLAPASVVFGKFSRYHINATHRNPRNLANALGVYSETPGEVKVLYTRNIKTGYHNLVPSQMKMRNYASLGQRASTYAGCQGITAPRVQIILDSDTPRCTRQVMYTALSRATTEVVLCNTMPDEKSFFQKVEATPYLKAILNLNKEIKVTEGDLTEEPPREPAPPTTHLPVENRIILNEALVEPLPDKHDREIYSNSTGFSNCIQTQDPYIQAFQHQQAKDETLFWATVEKRLAASTPKDNWTEFKTKRPLGDVLWLAYKRAMVLPDEPIKFNPELWWACADEVQKTYLSKPIHALKNGILRQSPDFDWNKLQIFLKSQWVKKIDKIGKIDVNAGQTIAAFYQPTVMLFGTMARYMRRIRDTYQPGEILINCEKNQKHISKWVESNWNHRLPAYTNDFTAYDQSQDGAMLQFEVLKALHHDIPHEVVEAYVALKLNSKMFLGTLAIMRLTGEGPTFDANTECNIAYTHARFEIPKNVAQMYAGDDCALNCRPVERQSFLPLVEKFTLKSKPKVFEQKVGSWPEFCGNLITPRGYLKDPMKLQHCLQLAQRKKPSEPGSLKDVAENYAMDLLPTYELGDALYEIFDERQMNAHYQSVRTLITCAHTKVLRVAQALQEDCTFFSSI
What is the function of this protein?
RNA replication.  The central part of this protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA replication protein, 152 kDa protein, ORF1 protein.
What is the protein family that this protein belongs to?
Belongs to the potexviruses/carlaviruses RNA replication protein family.
Protein: SYFA_DESAL
Sequence: MKTQIQELRTQALADIESAGDAKAIDELNIRYLGRKGLVNDLMKGMAKVPADEKPLIGRLANELKNDLQDAFAKAVEKFGSGKEAGDVVDVTLPGRPRKVGGLHPLTTINLEICDIFTRLGFDIAQGPEVELDYYNFEALNFPKDHPARDMQDTFFVSDNVVLRTHTSPMQVRTMEKQKPPVRVIAPGKVYRCDSDITHTPMFAQVEGLVVDKGISFADLKGVLTTLVHQIFDDKTPLRFRPSFFPFTEPSAEVDIGCVMCKGSGCRVCSHTGWLEILGSGMVHPRVFEFVGYDTSEISGFAFGMGVERIAMLKYGIDDIRKYYENDLRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBX21_HUMAN
Sequence: MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYYRGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
What is the function of this protein?
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931).  Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3.  Induces permissive chromatin accessibilty and CpG methylation in IFNG (PubMed:33296702).  Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity).  Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648).  Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC.  Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2.  Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes.  Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).  Required for the correct development of natural killer (NK) and mucosal-associated invariant T (MAIT) cells (PubMed:33296702).
What are the official names of this protein?
T-box transcription factor TBX21, T-box protein 21, T-cell-specific T-box transcription factor T-bet, Transcription factor TBLYM.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYDND_MYCSJ
Sequence: MLRSHAAGSLRPADAGQNVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGAVLEAAHRLRAEFCVAVEGVVEVRPEGNENPEIPTGGIEVNATSLTVLGESAPLPFQLDDEAGEEARLKYRYLDLRREGPGKALRLRSKVNAAAREVLARHDFVEIETPTMTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDADDVIAVSEEILKALWALIGHDLPTPLPRITYAEAMRRFGTDKPDLRFGLELVECKEFFADTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEWAKQRGAKGLAYVLVGDDGTLGGPVAKNLTDAERDGLAAHVGANPGDCIFFAAGPPKSSRALLGAARIEIAKRLDMIDPDAWAFTWVVDWPLFEMAEDATAAGDVAVGSGAWTAVHHAFTAPQPQSEATFDTDPAGALADAYDIVCNGNEIGGGSIRIHRRDVQERVFAMMGIEHDEAQEKFGFLLDAFTFGAPPHGGIAFGWDRITALLARMDSIREVIAFPKSGGGADPLTGAPAPITPQQRRESGIDAKPKKDGE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU2_STRRA
Sequence: MAKAKFQRTKPHVNIGTIGHIDHGKTTLTAAITKVLHDRFPDLNPFTPFDQIDKAPEERQRGITISIAHVEYQTEARHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKTDMVDDEEILELVELEVRELLTEYEFPGDDVPVVKVSALRALEGDPRWTRSVLELLDAVDEFVPEPVRDVDRPFLMPIEDVFTITGRGTVVTGRIERGTLNVNTEVEIIGIHEQRTRTTVTGIEMFRKLLDEGRAGENVGLLLRGVKREQVERGQVVIRPGSVTPHTQFEAQAYILSKDEGGRHTPFFENYRPQFYFRTTDVTGVVTLPKGTEMVMPGDNTAMHVQLIQPIAMEEGLKFAIREGGRTVGAGQVTRIVK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu-2, EF-Tu-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_AZOVD
Sequence: MSKKYFGTDGIRGRVGEYPITPDFMLKLGWAAGKAFRRQGICRVLVGKDTRISGYMFESVLEAGLSAAGADVLLLGPMPTPAIAYLTRTFHAEAGIVISASHNPHYDNGIKFFSGQGTKLPDELELVIEELLDNPMTVVDSAQLGKVSRINDAAGRYIEFCKSSVPTGTSFAGLKMVVDCAHGATYKVAPNVFRELGAEVAVLAAQPNGLNINDRCGSTDIVALQAEVLMQRADLGVAFDGDGDRVLMVDHTGAVVDGDELLFLIARDMHEHGKLQGGVVGTLMSNLGLELALQDMGIPFVRAKVGDRYVMAELLARNWQLGGEGSGHIVCCHHSTTGDGIIAALQVLRALKHRGQRLAEARQGMRKFPQVLVNVRYAGDKDPVGHPVVQEACERVTEQMAGRGRVLLRKSGTEPLVRVMVEGDDESQVRLHADNLAKIVSDVCA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: SEPT4_HUMAN
Sequence: MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY
What is the function of this protein?
Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli (PubMed:11146656, PubMed:15837787).  Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death (PubMed:15029247).  Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis (PubMed:29020630).
What are the official names of this protein?
Septin-4, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Peanut-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell projection, dendrite. Perikaryon. Synapse. Note=In platelets, found in areas surrounding alpha-granules (PubMed:15116257). Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity). SUBCELLULAR LOCATION: [Isoform ARTS]: Mitochondrion. Nucleus. Note=While predominantly localized in the mitochondria under resting conditions, translocates into the nucleus after TGF-beta treatment and apoptosis induction.
Protein: NMU_MOUSE
Sequence: MSRAAGHRPGLSAGQLAAATASPLLSLLLLLACCADACKGVPISPQRLQPEQELQLWNEIHEACASFLSIDSRPQASVALRELCRIVMEISQKPQEQSEKDNTKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRFKAEYQSPSVGQSKGYFLFRPRNGKRSTSFI
What is the function of this protein?
Stimulates muscle contractions of specific regions of the gastrointestinal tract.
What are the official names of this protein?
Neuromedin-U.
What is the protein family that this protein belongs to?
Belongs to the NmU family.
What are the subcellular locations of this protein?
Secreted.