PharMolix/UniProtQA huggingface dataset:
Protein: RL5_RHIE6
Sequence: MAEAKYEPRLKKEYVERIRKAMQEKFSYANEMMIPKLDKIVINMGVGEATADSKKPTVAAADLAAIAGQKPVITRARNSIAGFKVRENMPIGAKVTLRGARMYEFLDRLVNIALPRVRDFRGLNPKSFDGRGNFAMGIKEHIVFPEINYDKVDQMWGMDIIVCTTATTDDEARALLKEFSFPFRQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: METK_LEPBL
Sequence: MSLKDFIFTSESVGEGHPDKVCDQISDAILDAYLEQDPKSRVACETLATTNLVVIAGEITSKGKVDAQEIARNVIRDIGYNDITMGFDADFAVVSAHVHAQSPDISQGVTEGEGLFKEQGAGDQGLMFGFAINETPEFMPMPIYYSHELVKHLAGLRHSNKLKFLRPDAKSQVTVEYKDGKPVRVDTVVISTQHSPDVAHKQIEESLIEECIKKVIPANLLVNTKYFINPTGQFIVGGPHGDAGLTGRKIIVDTYGGYGRHGGGAFSGKDPSKVDRSAAYMGRYIAKNVVASGLADKCEVQLAYAIGVAEPVSVHVDTFGTGKISEEELVKRIRANFKLTPRGIIESLKLLEKGRKYRETASYGHFGRKGSTFTWEKTDKTVALKG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUS2_GIBF5
Sequence: MHKVFASDFFNFEFLRLLGTVPFQGAEVGECLTTAGRIKDGDPESWYRAWRDQAEKAQALAEEAAAVGDKTGACWAYIRAANYWRASEFLLHCTPKDPRILASSKASVNAFDKGWVLLDATVKNFEIPYEKDIKLPGRLYLPAPHHRLPGKIPVVLQTGGFDSTQEELYFYGAAGALPRGYAVFSFDGPGQGLPLRVGKLKLRTDWEYVVSQVLDFVTDDVAPEYDLDLERLAIFGASLGGYLSLRAAVDPRIKACVSCDGPLDLFEITRSRMPPWFINGWLSGWVSDGVFNWVVDGLTAVNFQIAWEFGHGKWVFGVETPADVLRVMQKISLKGGYLEKIKCPTLITGAADSFYFTPDINANIIFEGLTALEPNDKHLWIGKGVEGGGLQAKIGALAVVHHKMFTWLDSTFAIKRDVL
What is the function of this protein?
20-hydroxy-prefusarin hydrolase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:23932525).  Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (PubMed:23932525).  The roles of the other FUS members are yet undetermined (PubMed:23932525).  The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:23932525).  The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (PubMed:23932525).  This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (PubMed:23932525).  FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (PubMed:23932525).  As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (PubMed:23932525).  Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D (PubMed:23932525).
What are the official names of this protein?
20-hydroxy-prefusarin hydrolase FUS2, Fusarin biosynthesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: RL2_ANAPZ
Sequence: MSLRVLNSVTPSLRGTVLVDKTALWKGRPEKSLVSSRVSSGGRNSRGVITVRHRGGGHRRLYRVVDFKRNKEGVPAVVKRLEYDPNRTAFLALIQYEDGELSYILAPSGLKVDDVIMSGAGSDVLPGNCLKLSMIPSGTFVHNVEMKVGGGGIIARAAGSYAQVMGRDGAYVMLRLGSGEVRRILSVCRATVGVVSNLDNRNIKLGKAGRSRWLGLRPKVRGVAMNPVDHPHGGGEGKTSGGRNSVTPWGVPTKGKKTRKRGKHSDKYIRVSSVKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: IXTPA_STRCO
Sequence: MTRLILATRNAGKITELRAILADAGLPHDLVGADAYPHIPDVKETGVTFAENALLKAHALAEATGLPAVADDSGLCVDVLNGAPGIFSARWAGRHGDDQANLDLLLAQIADIADEHRGAHFACAAALALPDGTERVVEGQLKGTLRHAPAGTGGFGYDPILQPEGETRTCAELTAEEKNAISHRGKAFRALVPVVRELLG
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: SXIG_VOLCA
Sequence: MAVVVVNSATASLLAVCLVFMAVGLCTGQIVDVKFPSCRCERELTPFAIKSAATQLTSRNPGVVNLYCFEIGIVNSGSGACYTEPASQNLSKVSVYAQAAQRDRLSAFGVLLAGAPVSNMTYLTPRWDSLNMTTISNLNFSKTQANGTRICLELFKPTTINEFCEREGASGSFCWVALFNDNNCVPPNSTVVISKRLCCPRFQSFLSP
What is the function of this protein?
The sexual inducer is a glycoprotein synthesized and released by sexual males at about the time they release sperm packets.  It is one of the most potent biological effector molecules known: it exhibits full effectiveness in converting asexually growing males and females to the sexual pathway at about 10(-7) m.
What are the official names of this protein?
Sexual inducer glycoprotein.
Protein: CAPSD_TTVV4
Sequence: MWWWRRRFWRPKRRWRWRRRRRRPLARRRRRPARLARRPRVRRRRFQWGRPRRYRPRRRRRRRKRQKIKLKQWNPAVTKFCRIIGYYPLIICGEGTTVRNYNVHSQDYVQYESYGGGMTTTMFNLKVPYEQFQLHQNFWTRSNIDLDLVRYHSVKFTFFRHPKVDFIVKFNRNPPFTDSVLTGPMLHPGVLMNSKRKILIPSWETRPRGKKRIPVRIGPPRLFTDHWYFQRDFCGVPLLTVNATACNLRYPFGSPQTKNICIYFLVLASIYNDKVSIAKDEVTKNYDTLVDAIKKSPQGLTVFNTFKTQEHMQEPSSETCKETQKTNPPFKYENLSSLWGDKIYKESTFNSFKTNAENLWKARSKHTLLGSKELNFKTGMYSAIFLTNGRLSPDYPGIYIEVVYNPLLGQGEGNMIWLEWCPKKTKQYNERQCYNLIQHVPLWAAIHGYMDFCKKTFKDNNLDKNTRVVLICPYTRPQLYNPQKPDWGYVPYDYNFAQTKMPDGNGYIPEFYRFRWYPSGFHQQNWMNDLDQCGPFSHRGEEKMATLTSKYNFKFTWGGNPIFQQTVKDPCKQSTFDIPGAGGIPRPIQIVNPKYLDPGITFHRWDLRRGFFGPAAVKRMQAESTDALFPTTGPKRPRTEVPVAVAGDALPSRERKRQAWQDSTSEETESEAEAQEEKTLQEQLQQQLKEQRQLRCGIQYMFQQLTKTQLHLHVPPIPQ
What is the function of this protein?
Self assemble to form an icosahedral capsid.
What are the official names of this protein?
Capsid protein.
What is the protein family that this protein belongs to?
Belongs to the anelloviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: LSPA_BACC0
Sequence: MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFFYIITVVFVVFIVFYMKKYAKTDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSYNYPVFNIADSALCIGVVLIIIQTLLEGKKTKE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP6_ROTH3
Sequence: MDVLFSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIVTMNGNDFQTGGIGNLPVRNWNFDFGLLGTTLLNLDANYVETARTTINYFVDFVDNVCMDEMARESQRNGIAPQSDALRKLSGIRFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSFSFTLNRSQPQHDNLMGTMWLNAGSEIQVAGFDYSCALNAPANTQQFEHIVQLRRVLTTATITLLPDAERFGFPRVVNSADGATTWYFNPVVLRPNNVEVEFLLNGQIINTYQARFGTITARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFVHHATVGLTLRIDSAVCESVLADANETMLANVTSVRQEYAVPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLVK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: ILVD1_NOCFA
Sequence: MAEQTNTPDLKPRSRDVTDGLERTAARGMLRAVGMGDDDWEKPQIGVASSWNEITPCNLSLDRLAQGCKDGVFAAGGFPMQFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGIAKLSDGTEREVTIIDAFEAVGACARGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGYARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEARVELTLDDFARVGRRVPHLADVKPFGAHVMTDVDRIGGVPVMMKTLLDAGLLHGDCLTVTGRTVAENLAHIAPPDPDGKVVRALNDPIHPTGGITILSGSLAPGGAVVKSAGFDEDVFTGTARVFDRERAAMDALEDGTITAGDVVVIRYEGPKGGPGMREMLAITAAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHVAPEAVDGGPIAFVRDGDRIRLDVAAGTLDLLVEPAELERRKQDWRPLPPRYTRGVLAKYTKLVGSASVGAVCD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 1, DAD 1.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SLT1_SCHPO
Sequence: MATLFHLIDVHGNEYQNVQDHSLQMALEELNQQIEVIQRQEEQLALRKKAIEDARQEVLQQIQHRKFRQYLHEREQEARLQEYYLEQLQERRAFENVVRTIIRKRFEDEERERAHRREKAARKLLRRILVSDSPNMQLVVPNNFQQMFIHHPVVDTIYSPEESSESQAEVADQQTGPYSTSEYAGAQQSQPFRIFIQNDNAPEQQSGPDVAELNTLPNRSKTSSQASVSDEELSRTELAELNDYLLAAQRRSNKRGNARKHIDLTARESPSTSFAQMSKGALNPDPEVIEPEDEPTTFRNPLEALLSTGQYSVVSSDEDVESVRDPDDGTLPIHSTQTVEEPIDTKAGEKLTDSSKQPSPPVAEHFSNETFSASPKGAETDVKSEGSNNHEQGSFNEPKSNVDSNDSASPKRPSSQASLRHNVTVEEVPDEDA
What are the official names of this protein?
Protein slt1.
Protein: YA934_RHOBA
Sequence: MMNWDRIEGKWKQLKGQAQQQWGDLTDDDLDRVDGKREELVGVVQERYGLAKDEAEKQVQQFESSCNC
What are the official names of this protein?
UPF0337 protein RB10934.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: LAX4_MEDTR
Sequence: MLSQNQAEEAIVTNMNETEQEGGSSLEEIAEDQSMFNFKSFLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMVSGIVFQIFYGLIGSWTAYLISVLYVEYRARKEKENVNFKNHVIQWFEVLDGLLGRYWKALGLAFNCTFLLFGSVIQLIACASNIYYINDKLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYMAIAAIVNGQIENVVHSGPTKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKYIYFLATLYVFTLTIPSAVAVYWAFGDELLNHSNAFSLLPKNGFRDAAVILMLIHQFITFGFACTPLYFVWEKVIGMHDTKSICLRALVRLPVVIPIWFLAIIFPFFGPINSAVGALLVTFTVYIIPALAHMLTYRTASARKNAVEKPPSFLPSWTAVYVLNAFIVVWVLVVGFGFGGWASMTNFIRQIDTFGLFAKCYQCKPPTPPQAPSPHARH
What is the function of this protein?
Carrier protein involved in proton-driven auxin influx.  Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity).  May be involved in lateral roots and nodules formation.
What are the official names of this protein?
Auxin transporter-like protein 4, AUX1-like protein 4, MtLAX4.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATG15_CHAGB
Sequence: MSIGEVSDSAGHLASLVLPIEVAPIAPLIPEPPATAEHIFTLRHVYHHGTHKHPSLHRKHDVTPSNADVWLAAEDGYEAERIGPLRARSNALRIQRLVDRRPSVVDPMVAQSRQQGFVSVLSPSAWTVDDVAGPDVTDKGTVLTMALMAANAYVEGPGKADWQDVGAPFNRSLDFGWEGDGLRGHVFADENNSTIVIGLKGTSPAVFDGDGTTTNDKVNDNLFFSCCCAQQGPWTWHQVCDCATGTYTCNNTCVTQALREENRYYQAARELYANVTEVYPDSHVWIAGHSLGGAVSSFLGLTYGVPVVTFQAVPDALPAGRLGLPVPPGADPNAPQSRDYTGAFHFGHTADPIYMGSCNGATASCSFAGYALESACHTGHECVYDTVGDKGWRVGIGTHKIVAVIRDVILKYDTVPECKFTPECRDCGNWKMYESNGTETTTTSSAPTTTSISRTRTETCKTPHLKSQQQRQRPRPRPLHALPQWEGGNPDSPERNEEM
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase atg15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: PA2BX_PROFL
Sequence: HLLQFRKMIKKMTGKEPIVSYAFYGCYCGKGGRGKPKDATDRCCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCGGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFCTDPTEGC
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 PL-X, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMP_BORA1
Sequence: MADLFALTEEALAGMGIELVDVERAALGLLRVTIDREDGVRIEDCEQVSRQLSRVYEVENIDYKRLEVGSPGVDRPLRNEAEFRRFAGERIEIKLREAVDGRKVFTGILQEADTSADDKTVFGLEFEAKKDDIQVLSFTLDDIERAKLDPVLDFKGKKR
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_NITEU
Sequence: MSIKSDKWIRRMAAEYNMIEPFEPNQIKQRNGESIVSYGTSSYGYDIRCSDEFKLFTNLNSTIVDPKRFDSNSFVDVKGDICIIPPNSFALARTVEYFRIPRNVLTICLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVIFFESDEVCETSYKDRNGKYQFQQGVTLPKI
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: DAPA_BUCAP
Sequence: MFKGSIVALITPMNEEGEICHSSLKKLIDYHVLNKTKAIVSIGTTGESATLSQEEHIEVVMLTLKLANKRIPIIAGTGANATTEAISLTKRFEKSGIEACLTVTPYYNKPTQEGLYQHFKAISENTKLPQILYNVPSRTGCDLLPSTVARLSEFKNIIGIKEATGDLSRIHKIKKLVKDDFLLISGDDPTALDFIQLGGQGVISVTANIAAKEMTQMCSYALEGNFKSARSINERLMLLHESLFIEPNPIPIKWLAKKIGLIKSDTLRLPMTPILNSTRTQIEKALQYANLQKI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_ZYMMO
Sequence: MNKPFSASILTLYPEMFPGPLGHSLAGRALENNIWSLETVAIRDFANDRHHTVDDTPSGGGAGMVMRADILARALDHSCEKHPDLPVLAMTPRGYPLTQSRVRQLSEGAGAIIICGRFEGMDERLFEKRAIEPVSIGDYILSGGEMAALTLLDACIRLIPGVMGKITSGEDESFETGLLEYPQYTRPVEWEGLSIPEVLRSGNHAHIKAWRQAMAERDTRLRRPDLWERYRSVQASRPLARNKKDRNEK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_BACC3
Sequence: MKIALIAHDKKKDDMVSFAYAYKPIFEQHELFATGTTGLRIMEATGLVVTRYQSGPLGGDQEIGAMIAKNDLDMVIFFRDPLTAQPHEPDVNALLRLCDVYAIPLATNMASAEMLMHALERGDLDYRKLRK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PRX8_PENRF
Sequence: MAVIFSSSALDSHTHVDKHLVRRPIRDLENNVDMLDHLSRVLTLSYQYHALGTAIALFACACAYALVAPRQPPKFPAPQLYDETGPIDLIALDKTIREGFQNYKGKYFTLKEAHGETVILPTKFMEELKALPDNMLNLDDEIDERFLSEHSLFTTTSVGGRISTVVNSVKNELTKTLGHLMGDIHEEVVYSFQELIPPCDDWTEIDIQSKLVRIVALVSGRIFVGLPMSRNQEYLDCIIEFTLNVFFAVPEIRAYPRLLRWTSRYLNTKVRAVHKSLATMRRLMAPIIAGTKQQLEMGTGPHNMCAWNIKNSNQKERDSLNIQAQMQLATSMAAIHTTSMTVTNAIFDLAARPEYLQPLRDELQDLRATEPLPYLNKSSMPKLRKLDSFLKESHRLSPISLLNMRRKIVQPITLHDGTVLQPGMHIAFPLHQVSNDEDLWENPSQFDGFRFQKLRDLPGNESKYQFTATGTNNLDFGYGVHACPGRFFAANEIKMILVHLIDNFDFKFKGDIGRPDSLWTPGGYHPDPSVRVLLKRRLKA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF6 is probably also involved in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
Cytochrome P450 monooxygenase ORF5, PR-toxin biosynthesis cluster protein 5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YBIX_ECOBW
Sequence: MMYHIPGVLSPQDVARFREQLEQAEWVDGRVTTGAQGAQVKNNQQVDTRSTLYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPQSYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDNNIQSLKSRYGESEEILSLLNLYHNLLREWSEI
What are the official names of this protein?
PKHD-type hydroxylase YbiX.
Protein: KPB1_RAT
Sequence: MRSRSNSGVRLDSYARLVQQHTILCHQNPVTGLLPASYDQKDAWVRDNVYSILAVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNACSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNTLLPRASTSKEVDASLLSVISFPAFAVEDSKLVEITKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNTEQVQEYREALDAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGNLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARILSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIYTFTPQFIDQQQFYLALDNQMIVEMLRTDLSYLCSRWRMTGQPTITFPISHTMLDEDGASLNSSILAALRKMQDGYFGGARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYDDELDSGNWMDSYDSTRNARCGDEVARYLDHLLAHTGPHPKLTPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHIQNVHMYLPTKLFQPSRPSLNLLDSPESPQDSQVPSVRVEVHLPRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYTMKGPDWNTELYEEGGSTVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHLTVGLPPEPREKTISAPLPYEALTKLIDEASEGDMNISTLTQEIMVYLAMYMRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMRNLLHHILSGKEFGVERSVRPTDSNVSPAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSVSPESQTSGGHPSSIDLMSPTFLSPAACISASSGSFPTVCEPQTSKDSRQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSSTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIEIHSIGSIIAVEKIVHIANDLFLQEKKTLGADDIMLAKDPASGICTLLYDSAPSGRFGTMTYLSKAAATYVQEFLPHSLCAVQ
What is the function of this protein?
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.  The alpha chain may bind calmodulin.
What are the official names of this protein?
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform, Phosphorylase kinase alpha M subunit.
What is the protein family that this protein belongs to?
Belongs to the phosphorylase b kinase regulatory chain family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.