PharMolix/UniProtQA huggingface dataset:
Protein: IXTPA_STRT1
Sequence: MTKSIFEYKDDQDWYLASFGSYNHLTYFGDDEAYEQYVDFFQGLTNTLDVSGFQLHVVKHSSDLRLVSFILDCLKEELGRDLVVTQHQGTLLVSEGDKLLYVHVPREGVSLDGFFGSDNKSDFGDVLLIATRNEGKTKEFRKLFGKLGIKVENLNDYPDLPEVAETGMTFEENARLKAETISKLTGKMVLSDDSGLQVDVLGGLPGVWSARFAGPEATDAENNAKLLHELAMVLDDSKRSAQFHTTLVVAAPGRDSLVVDADWKGYIGREPKGDNGFGYDPLFLVGNTGRTAAELSTEEKNEQSHRGQAVKKLMEVFPAWQNKQ
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: PATC_ASPCL
Sequence: MAESTAHTSPSLNDKEREVDQGILSDESGPAEEVKETPDQERSVQGVRWLLICIAVFSANLLYGLDNTIVADIQGAVAGTFEEYAQLGWLGVGFTLGSVVFILPLGKAYAIFDTKWLFIGCLTMFAAGSALCGGAPNMDAIIVGRVWAGAGGAGMYLGNLNLITILTTPKEQPVYVGLVGLIYGVGCILGPIIGGAFADSSATWRWGFYINLIIFGIMAPIYVFLLPSLPRPAGEGRSFINRLRELDWVGTVLSAGMHVSFILFIVFGGVMWPWTDGRNIALYVVAAVTLIAFALSQYFCVLTDKENRLFPGEFLRNPTMIALYVLMACGGAALFVAVYYIPLYFQFVHGDSGIMSAVRLLPFICFYVATILLCGWLMPKTGYYVLWYLLSGIFMVIGSATMYTVKYDTKVANIYGYSILLGLGMATTQAAYAVGPSLVTPDRVAESIQFMNIGQGQSQLLGLAIASAIFQSETLSGLNALLAGKGYSQGDIQGAIAGARSTLLTELPADLKTKALDVIVHSIDDVYVMAIAAGALYVIASCFLPWRRF
What is the function of this protein?
Efflux pump; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:19383676).  May be involved in the secretion of E-ascladiol to be converted to patulin by the secreted patulin synthase patE (By similarity).
What are the official names of this protein?
Efflux pump patC, Patulin synthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein.
Protein: ARGO_SALPB
Sequence: MISYYFQGVALGAAMILPLGPQNAFVMNQGIRRQYHLMIALLCALSDLVLISAGIFGGSALLMQSPWLLALVTWGGVAFLLWYGFGALKTAMSSNLELASAEVMKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLAMEPKRWFALGTISASFLWFFGLALLAAWLAPRLRTAKAQRIINILVGVVMWLIAFQLAREGVAHMHALFN
What is the function of this protein?
Involved in the export of arginine.  Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
What are the official names of this protein?
Arginine exporter protein ArgO.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCH1L_BUCAP
Sequence: MENFLLEKIINKKLSSDQYSDVVPNGLQIEGEKIIKKIITGVTACQELLDKALSYGANAIIVHHGYFWKNESQCIHNMTRKRLTTILSNNINLYSWHIPLDIHPKLGNNAQIAKKLNIRIKGYILPYLFWGTLEENINAFDFSKKIEKKYEKKPIHIYANAPIYISRIAWCSGRGQNFIKQAYNFGIDAFLTGEISEETMHIAKELGIHFFSIGHHATEKDGIKSLGKWLNNKYDLDVTFIDIHNPA
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: RL10_ALKOO
Sequence: MVKAIDIKKEQVAEITDKLQRSASAIVVDYRGLKVEEVTELRKQCREKGLEYKVYKNTLTRLAAENAGMKELVGELVGPNAIVFSYDDPVAAAKVASEFAKTHKNLELKAGLVEGVLYKDAQLEEFASIPSREVLIAKLLGSFKAPISNFAYLIKAIADKKEAEGQA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HBA_VULGR
Sequence: VLSGSDKTNVKGVFAKIGGHAEDYGAETLERMFITYPQTKTYFPHFDLQHGSAQIKGHGKKVVGALIEAANHIDDIAASLSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSVLTPEVHASLDKFLCAVGNVLTAKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-A, Alpha-A-globin, Hemoglobin alpha-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: OL139_MOUSE
Sequence: MEPGAWGNRTAVTDFILLGLTGNVRLQPILFVVFFFAYIVTVGGNLSILAAIFVEPKLHTPMYYFLGNLSLLDIGCISVTVPPMLVCLLAHECRVPYAACISQLFFFHLLAGVDCHLLTAMAYDRYLAICQPLTYSTRMSREVQGTLVGICCTVSFINALTHTVAVSVLDFCGPNVVNHFYCDLPPLFQLSCSSIYLNGQLLFVGATFMGVVPMILISVSYAHVAAAVLRIRSTEGRKKAFSTCGSHLTVVCIFYGTGFFSYMRLGSVSASDKDKGIGILNTILSPMLNPLIYSLRNPDVQGALKRVLTGKRYPV
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 139, Odorant receptor M5, Olfactory receptor 1, Olfactory receptor 255-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSRP_DINSH
Sequence: MAKPKTPEEKNYKVIAENRRARREYAIEEDLEVGIVLEGSEVKSLREGGSNIAESYATVDDGELWLVNSYIAPYAQAKTWKHEERRRRKLLVSRRELSRLWNATQRQGMTLVPLVMYFNHRGLVKLKIGVAKGKKLADKRQTDAKRDWNRQKQRLLKQNL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ARGC_MYCTA
Sequence: MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_STRP3
Sequence: MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQE_PSEAB
Sequence: MRNSGSSCSESVGPPLWLLAELTYRCPLQCPYCSNPLEFAREGAELSTAEWIEVFRQARELGAAQLGFSGGEPLLRQDLAELIEAGRGLGFYTNLITSGIGLDEARLARFAEAGLDHVQISFQAADEEVNNLLAGSRKAFAQKLAMARAVKAHGYPMVLNFVTHRHNIDNIERIIQLCIELEADYVELATCQFYGWAALNRAGLLPTRAQLERAERITAEYRQRLAAEGNPCKLIFVTPDYYEERPKACMGGWASVFLDITPDGTALPCHSARQLPVQFPNVREHSLRHIWYESFGFNRYRGDAWMPEPCRSCEEKERDHGGCRCQAFLLTGDADATDPVCAKSARHDLILAARRQAEEAPLGLDALTWRNQRASRLICKA
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: PFA3_YEAST
Sequence: MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIVPTLAVALYTYYKVIARGPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGRFRVCQVCHVWKPDRCHHCSSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYAFLVLIYTCYELGTWFNSGSFNRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQTTIEVHGMRRYRRDLEILNDSYGTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIETFKYKKSKHTKDEKGLYFNVRPQVQDRLLSSRCLEDQLLRRVTPRPSLEADRASVEIIDAN
What is the function of this protein?
Palmitoyltransferase specific for VAC8.  Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization.
What are the official names of this protein?
Palmitoyltransferase PFA3, Protein fatty acyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: HIS8_SHIDS
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSCGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLENWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAALKEISCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RIBB_PHOPO
Sequence: MTLSTAQEIIEDIHQGKMVILMDDEDRENEGDLIIASDKVTPEAINFMATYGRGLICLTLNKERCLQLELPMMVKSNTDKFATPFTISIEAASGVTTGISVNDRARTVQAAIAATATAKDIVMPGHIFPLMAQDGGVLARAGHTEAGCDVARLAGLEPSSVIVEILNDDGTMARRPQLEVFAKKHGLKLGTVADLIEYRNKYETMIERISECKLNTEFGEFDMITYRDKINHQIHYALQKGNIEPNSQTLVRVHLQDTFKDILQTGSTRWTLPAAMERISSENGVLVIVTKQEDPEMVISKIQNLALENKETPVVNSQSRQVGLGSQILSDLGIRKMRLLSSSSHLYHSLSGFGLEIVEYVCS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: UREG_CUPMC
Sequence: MTRTKKNPPLRVGVGGPVGSGKTTLLEMLCKAMRDRYDLVAITNDIYTKEDQRLLTISGALPAERIMGVETGGCPHTAIREDASINLEAVDRMLAKFPDADVVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPYVGASLEIMESDARKMRGERPFVMGSVKSGQGLDQVIAFIERQGMLDV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB3_OOMCK
Sequence: MREIVHIQAGQCGNQIGAKFWQVISDEHGVDPTGTYKGDSDLQLERINVYYNEATGGRYVPRAVLIDLEPGTMDAVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRNEAESCDCLQGFQMTHSLGGGTGSGMGTLLIAKLREEYPDRVMMTFSVCPSPKVSDTVVEPYNATLSVHQIVENTDESFVLDNEALYDICFRTLKLTTPTYGDLNHLVCVCMSGVTSSLRFPGQLNCDLRKVAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQCFDAKNMMCAADPRHGRFLTASCMFRGRMSTKEVDEQMLNVQTKNSSYFVEWIPNNIKASVCDIPPKGLKMSSTFVGNSTAIQEMFKRVGEQFTAMYKRKAFLHWYTGEGMDDMEFTEAESNMNDLVSEYQQYQEASADDEADEFDEEEGDEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-3 chain, Beta-3-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TRPC_POLNA
Sequence: MSDILNKIIAVKREEITDAINRKPLPAMRKDAESRVLTRDFVGALRAKIAAGKPAVIAEIKKASPSKGVLRADFIPADIAQSYAEFGAACLSVLTDQQFFQGSIDYLKQARASCSLPVLRKDFIIDAYQVYESRVMGADCILLIAACLDDAQMKTLEALAMSLDMAVLVEVHDEAELERALKLRTPLIGINNRNLNTFEVSLDTTLRLMGKVPAERLLVTESGITTPEDVKRMRDARVNAFLVGEAFMRADEPGVALAELFGE
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: GPDA_VIBC3
Sequence: MSETQNHNSYGKPVEMTVIGAGSYGTSLAISLARNGANIVLWGHDAEHMARLDADRANHEFLPGIAFPDTLIVETDLQKAVQASRDLLVVVPSHVFGIVLKSLQPHLRADSRICWATKGLEPETGRLLQDVAHDVLGDSYPLAVLSGPTFAKELAMGMPTAISVASPDAQFVRDLQEKIHCSKTFRVYANSDFIGMQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGAQPETFMGMAGLGDLVLTCTDNQSRNRRFGLALGQGKDVDTAQTDIGQVVEGYRNTKEVWMLAKRMGVEMPIVEQIYQVLYQGKDARLAAQDLLARDKKMER
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YSAB_SHISS
Sequence: MMMNAFFPAMALMVLVGWSTPSPVQKAQRVKVDPLRSLNMEALCKDQAAKRYNTGEQKIDVTAFEQFQGSYEMRGYTFRKEQFVCSFDADGHFLHLSMR
What are the official names of this protein?
Uncharacterized protein YsaB.
Protein: REX_STRPZ
Sequence: MVIDKSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGIDSATVRRDFSYFGELGRRGFGYDVTKLMNFFADLLNDHSTTNVILVGCGNIGRALLHYRFHDRNKMQIAMGFDTDDNALVGTKTADNIPVHGISSVKERIANTDIETAILTVPSIHAQEVTDQLIEAGIKGILSFAPVHLQVPKGVIVQSVDLTSELQTLLYFMNQNHLD
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_ECOLI
Sequence: MTLKELLVGFGTQVRSIWMIGLHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETKDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEYKRQDLVYEKEDLLISGPGKYPEYNFYRMAGMAIDGKDKGEAENEAKPIDVKSLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I, NUO9.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PFLB_STAAS
Sequence: MLETNKNHATAWQGFKNGRWNRHVDVREFIQLNYTLYEGNDSFLAGPTEATSKLWEQVMQLSKEERERGGMWDMDTKVASTITSHDAGYLDKDLETIVGVQTEKPFKRSMQPFGGIRMAKAACEAYGYELDEETEKIFTDYRKTHNQGVFDAYSREMLNCRKAGVITGLPDAYGRGRIIGDYRRVALYGVDFLMEEKMHDFNTMSTEMSEDVIRLREELSEQYRALKELKELGQKYGFDLSRPAENFKEAVQWLYLAYLAAIKEQNGAAMSLGRTSTFLDIYAERDLKAGVITESEVQEIIDHFIMKLRIVKFARTPDYNELFSGDPTWVTESIGGVGIDGRPLVTKNSFRFLHSLDNLGPAPEPNLTVLWSVRLPDNFKTYCAKMSIKTSSIQYENDDIMRESYGDDYGIACCVSAMTIGKQMQFFGARANLAKTLLYAINGGKDEKSGAQVGPNFEGINSEVLEYDEVFKKFDQMMDWLAGVYINSLNVIHYMHDKYSYERIEMALHDTEIVRTMATGIAGLSVAADSLSAIKYAQVKPIRNEEGLVVDFEIEGDFPKYGNNDDRVDDIAVDLVERFMTKLRSHKTYRDSEHTMSVLTITSNVVYGKKTGNTPDGRKAGEPFAPGANPMHGRDQKGALSSLSSVAKIPYDCCKDGISNTFSIVPKSLGKEPEDQNRNLTSMLDGYAMQCGHHLNINVFNRETLIDAMEHPEEYPQLTIRVSGYAVNFIKLTREQQLDVISRTFHESM
What is the function of this protein?
Catalyzes the conversion of pyruvate to formate and acetyl-CoA.
What are the official names of this protein?
Formate acetyltransferase, Pyruvate formate-lyase.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBX2B_CHICK
Sequence: MADGGASPAQQEGEMSAAGPGLRRERQHRGSGRPPSARDLQLALAELYEDEAKRQSLRSDKPTTTKMSNSKGLKIDSFRSLRKPERSMSDDKENQRFYSGDSEYRGLQIWGASNNPSKIVAELFKEAKEHGAVPLDEASRTSGDFSKAKSFSGGGYRLGDSSQKHSEYIYGENQDVQILLKLWRNGFSLDDGELRSYSDPINAQFLESVKRGEIPVDLQRLVHGGQVNLDMEDHQEQEYVKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAPVLIDDSVPATKIQIRLADGSRLIQRFNQTHRIKDIRDFIIQSRPAFATTDFVLVTTFPNKELTDESLTLREADILNTVILQQLK
What is the function of this protein?
Adapter protein required for Golgi and endoplasmic reticulum biogenesis.  Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis.  Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase.  Also, regulates spindle orientation during mitosis.
What are the official names of this protein?
UBX domain-containing protein 2B, NSFL1 cofactor p37, p97 cofactor p37.
What is the protein family that this protein belongs to?
Belongs to the NSFL1C family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosome during mitotic prophase and metaphase.
Protein: RL23_STRZP
Sequence: MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEAAFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ENV_SIVEK
Sequence: MKVTEMQKNWLICCLLIGLIKIIGSELWVTVYYGVPVWRDAETVLFCASDAKAHSTEAHNIWATQACVPTDPNPQEVLIPNVTERFDMWKNNMVDQMQEDIISLWEQSLKPCVKLTPLCVTLSCSSWRSVNNSVNQTNHVQMQNCSFNVTTELRDKKKQVYSLFYMGDIIPLDTNNSSGNNSQYRLINCNTTAVTQACPKISFEPIPIYYCAPPGFAIIKCNDQDFNGTGECNNVSTVQCTHGIKPVISTQLILNGSLATSNIVIRNNSKDTLLVQLNESIPINCTRPGNKTRGQVQIGPGMTFYNIENIIGDTRQAYCEVNRTWEQIWNTTKQIIINNRKNITFIPNPGGDLEVTNLMINCGGEFFYCNTSQLFTNQNGNTTGNITLQCRIRQIVNLWTRVGKGIYAPPIKGPINCLSNITGIILDYTKSGTEKYTIYPTGGDMTNLWRQELYKYKVVSIEPIGVAPGKAKRHTVTRQKRAAFGLGALFLGFLGAAGSTMGAASITLTVQARKLLSGIVQQQNNLLRAIEAQQHLLQLSVWGIKQLQARVLAIERYLRDQQILGLWGCSGKSVCYTNVPWNTTWSNNNSYDTIWGNMTWQNWDEQVRNYSGVIFGLLEQAQEQQSINEKSLLELDQWSSLWNWFDITKWLWYIKIFIMVVAGIVGIRIISIIMSMVARVRQGYSPLSLQTLIPTTRGPDRPERTEEDAGELDNGRSVRLVSGFLALAWEDFRNLLLFLYHRLTDCLSILRRTLELLRQNIHKGLQLLNELRIYLWGIIAYWGRELKISAINLLDTTAVAVAEGTDRIIELVQRIGRGILHIPRRIRQGLERALL
What is the function of this protein?
Oligomerizes in the host endoplasmic reticulum into predominantly trimers.  In a second time, gp160 transits in the host Golgi, where glycosylation is completed.  The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: MELB_ECOLI
Sequence: MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNATRSRWGKFKPWILIGTLANSVILFLLFSAHLFEGTTQIVFVCVTYILWGMTYTIMDIPFWSLVPTITLDKREREQLVPYPRFFASLAGFVTAGVTLPFVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVFSSDNQPSAEGSHLTLKAIVALIYKNDQLSCLLGMALAYNVASNIITGFAIYYFSYVIGDADLFPYYLSYAGAANLVTLVFFPRLVKSLSRRILWAGASILPVLSCGVLLLMALMSYHNVVLIVIAGILLNVGTALFWVLQVIMVADIVDYGEYKLHVRCESIAYSVQTMVVKGGSAFAAFFIAVVLGMIGYVPNVEQSTQALLGMQFIMIALPTLFFMVTLILYFRFYRLNGDTLRRIQIHLLDKYRKVPPEPVHADIPVGAVSDVKA
What is the function of this protein?
Mediates the transport of melibiose and other galactosides by a symport mechanism (PubMed:45782, PubMed:3311166, PubMed:3316227, PubMed:2185831, PubMed:7703254).  Can use sodium, lithium and protons as coupling cations, depending on the sugar substrate and the cationic environment (PubMed:45782, PubMed:3311166, PubMed:3316227, PubMed:7703254).  Alpha-galactosides (melibiose, raffinose, p-nitrophenyl-alpha-galactoside or methyl-alpha-galactoside) are cotransported with either Na(+) or H(+), whereas beta-galactosides (lactose, L-arabinose-beta-D-galactoside, D-fructose-beta-D-galactoside, methyl-beta-galactoside or p-nitrophenyl-beta-galactoside) are cotransported with Na(+) or Li(+) but not H(+) (PubMed:45782, PubMed:3311166).  The monosaccharide D-galactose can use either Na(+) or H(+) for cotransport whereas D-fucose, L-arabinose and D-galactosamine can use only Na(+) (PubMed:3311166).
What are the official names of this protein?
Melibiose permease, Melibiose carrier, Melibiose transporter, Melibiose/cation symporter, Na+ (Li+)/melibiose symporter, Thiomethylgalactoside permease II.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL7_STRS2
Sequence: MALNIENIIAEIKEATILELNDLVKAIEEEFGVTAAAPVAVAAAGGAAEEAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPAMVKEGVATAEAEEIKAKLEEAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.