PharMolix/UniProtQA huggingface dataset:
Protein: RPIA_METPB
Sequence: MSAPDLKRAAAERAIPLVEDGMRLGIGTGSTAAAFIALLGERVRAGLTVTGVPTSEATRIACEREGIPLATLEELPELDLTIDGADEVDGNLRLIKGGGAALLREKIVAAASRRMVVIADASKRVETLGAFPLPVEVNLFGIGATTRAVEAAVAAAGCIGEIVRRLDKAGQPVLTDGGHALLDLRLGRIPDPEALSARLWAVPGVVEHGLFLGIADAAILAAAEGDQAVVSVLGRL
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: HEM3_YERPG
Sequence: MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEGGCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSLGAREILAAVYLDNPAR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: SAA2_NEOVI
Sequence: MKLFTGLIFCSLVLGVSSQWYSFIGEAVQGAWDMYRAYSDMREANYKNSDKYFHARGNYDAAQRGPGGAWAAKVISDARERSQRVTDLFKYGDSGHGVEDSKADQAANEWGRSGKDPNHFRPSGLPDKY
What is the function of this protein?
Major acute phase reactant.
What are the official names of this protein?
Serum amyloid A-2 protein.
What is the protein family that this protein belongs to?
Belongs to the SAA family.
What are the subcellular locations of this protein?
Secreted.
Protein: S22AP_HUMAN
Sequence: MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAAPQRSSVL
What are the official names of this protein?
Solute carrier family 22 member 25, Organic anion transporter UST6.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MSRQ_SALPB
Sequence: MRLTAKQITWLKVCLHLAGFLPLLWLFWAINHGGLSADPVKDIQHFTGRTALKFLLATLLVSPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLVLLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPIHYLWSVKILSPQPVIYAALALALLALRYRKFRQWWR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDB2U_TITCO
Sequence: MVSKSLIVLLLVSVLVSTFFTTEAYPASYDDDFDALDDLDGLDLDDLLDSEPADLVLLDMWANMLDSQDFEDFE
What is the function of this protein?
May be an antimicrobial peptide.
What are the official names of this protein?
Anionic peptide clone 9.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUON1_HERA2
Sequence: MNDLTFITPEINWTVLGMPAFLMIWAMLVLIVDMFTSDRRVLLTLSLIGLGVTAALGALDYGSTISGFSDMLVFDKFGVLVNWILLAGTALTLLIAFDYMPRQNLSQGEFYPLVLFATSGMLFLVQSTDLVTIFIGVETLSIALYVLTGFAVPQFKSGEAAIKYLLLGGFAAGFLVYGIALIYGMTGKTNLAQIANELSTWQSTGKALDDPILLAGVGFVLIALGFKVSMFPFHAWTPDVYEGAPTPVTAYMSVATKGAAFAAMLRFLNVAFPALKPEWQLLFGLFAAATMAYGNIVAVAQTNLKRMLAYSSIAHAGYMLLGVLAASEKGISAFTVYLLAYTLTNLGAFAVLIALENRGMPVFELSDLRGLGKRSPLLALAMTVFMFSLAGVPPTAGFASKFGIFRAAWDANLDYLAIIGVVTSVISAFFYLRVIVTMWMRDTEATEPQPTYATASLSLGVIVAVIGIIAVGILPNIFTDLAKALVLTVAP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N 1, NADH dehydrogenase I subunit N 1, NDH-1 subunit N 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BZIP8_CAEEL
Sequence: MSNTMQGAHYPQMAFDPTWQMHPAYATATAFNPYNVSFDFTRSPNTSGGSDESMSDGSKIDPKRSPKYLEKRMKNNEAAKKSRASRKHREQKNQTENELLKRKNAALEEELKQAKCELAQMQITIRDMSIEREAYRRENEMLKMVNNKFADSKFEPPQPLRDMTNCNLPYKYELLS
What are the official names of this protein?
bZIP transcription factor 8.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
Protein: PSRP_BURA4
Sequence: MLPTVFIVSDGTGITAETFAHSILSQFDQKFRLVRLPFVDSLEKAYATVEKINDAAVHDGRRAIVFTTLVDSESNDIVKRSNALVLDMFQRFVEPLEQELELKSSHAMGRGHQNADTEEYKTRIEAINFSLAHDDGQSNRNLSEADVILVGVSRSGKTPTSLYLAMQYGVKAANYPLIPEDFERGKLPSALTPHRDKLFGLSIDPQRLSEIRNERRPGSKYAAPENCRYEINEAEAMMRREGIKWLSSTHKSIEEIATTILQEIRLDRQSY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: ACYP_XANC8
Sequence: MQAARFIFTGVVQGVFFRASTRERALALQLRGHARNQADGSVEVVAAGSAAALEALEHWLWQGSPASKVASVTRTPCAIPTTEAFVTG
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RS3_PELPD
Sequence: MGQKVNPIGFRLGVIKSWDSKWYAEADYAKLLHEDLKIRAFLKKRLYSSGISKIEIERAANKTKINIYTARPGLIIGKKGSEVETIKKELSNLTSKEIFINIIEVRKPELDAQLVAENVALQLERRIAFRRAMKKSVTSALKFGAKGIRITCSGRLGGAEMSRTEWYREGRVPLHTLRADIDYGCAEAKTTYGLIGIKVLIFKGEVLPGH
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MTNN_ALIFS
Sequence: MKIGIIGAMEQEVAILKDKIEGLSTITKAGCTFYTGTLNGADVVLLQSGIGKVAAAVGTTLLIAEHNVDVVLNTGSAGGFDSSLNLGDVVISTEVRHHDADVTAFGYEMGQMAQQPAAFIADEKLITTAEQALTEMSDKHAVRGLICTGDVFVCTPERQEFIRTHFPSVIAVEMEASAIAQTCHQFNTPFVVVRAISDVADKESPMSFDEFLPLAAQSSSEMVLNMVTLLK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: KCP2_PINMG
Sequence: MLASCHITSLSGILLLLCVQCSAQILINPCGDVPGVRGPCSANLRRFTFAYGRCVPFYYGGCLGTRNRFDSFVECERRCLGGPCNQTPGVVGRCYAAIPRYTYVPFPINSCVSFTYGGCEGNDNNFEDVNVCFNLCVFRRG
What are the official names of this protein?
BPTI/Kunitz domain-containing protein 2, Prism serine protease inhibitor 2, PISP2.
What are the subcellular locations of this protein?
Secreted.
Protein: VDR_CHICK
Sequence: MSELRGSWDEQQQSMAYLPDADMDTVAASTSLPDPAGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFNGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVIDTLLEAHHKTFDTTYSDFNKFRPPVRSKFSSRMATHSSSVVSQDFSSEDSNDVFGSDAFAAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDILQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity).  Plays a central role in calcium homeostasis (By similarity).  Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
What are the official names of this protein?
Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4.
Protein: CBID_METM6
Sequence: MSKIDFRLEKTFGYTTGACAAAGAYSALYFLKNNEKLNFVEILNLKGDSLIIPIKNIEKRGNTAVSTVEKFAGEDIDITNGMDIKIEVILENWDDGYPKPSNVIIIGGTGVGLITKSGLQIKPGDHAINPKPREMIETNLKSLLKDDEYVTVKISVPTGDEIAKKTLNPKLGIVGGISILGTTGIVRPMSNEAYKESLAPQIDVALANNFENLIFVPGNIGTKHAKILLNAEEDQIIEVSNFWDYMLDKAKEKGVKDIMVFGHAGKIVKLAGGIFDTHSRVADARNEILCAYASLVSQDVEMLQKILQSNTTEDIVEILTEKGILSEVFNKVSKRVVERLSLRWEGINFSCIVIDMKGNILGKSD
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: MPEG1_RAT
Sequence: MNSFMAIALIWMMIACAEADKPLRDPGMTGFQTCKDTLKLPVLEVLPGGGWDNLRNIDMGRVIDLTYTNCKTTEDGQYIIPDEVYTIPQKESNLEMNSEIRDSWVNYQSTTSFSINTELSLFSKVNGKFSTEFQRMKTLQVKDQAVTTRVQVRNRIYTVKNSPTSELSFGFTNALMDICDQLEKNQTKMATYLAELLVLNYGTHVITSVDAGAALVQEDHIRSSFLLDNQNSENTVTASAGIAFLNIVNFKVETDHTSQTLLTKSYLSNRTNSRVQSFGGIPFYPGITLETWQKGITNHLVAIDRAGLPLHFFIKPDKLPGLPGGLVKKLSKTVETAVRHYYTFNTHPGCTNVDSPNFNFQANMEDDSCDAKVTNFTFGGLYQECTELSGDALCQNLEQKNLLTGDFSCPSGYTPVHLLSQTHEEGYSRLECKKKCTLKIFCKTVCEDVFRVAKAQFRAYWCVATGQVPDNSGLLFGGLFTDKSINPMTNAQSCPAGYIPLNLFESLKVCVSLDYELGYKFSVPFGGFFSCIMGNPLVNSDTAKDIGAPSLKKCPGGFSQHLAVISDGCQVSYCVKAGIFTGGSLLPVRLPPYTKPPLMSQVATNTVIVTSSETARSWIKDPQTNQWKLGEPLELHKAMTVIHGDGNGMSGGEAAGVTLGVIIALGIVITLAIYSTRKYKKEKEYQEIEEQESLVGSFATDASPPNGEQDPCPA
What is the function of this protein?
Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity).  By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity).  Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity).  Reduces the viability of the intracytosolic pathogen L. monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity).  Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).
What are the official names of this protein?
Macrophage-expressed gene 1 protein, Macrophage gene 1 protein, Mpg-1, Perforin-2, P-2.
What is the protein family that this protein belongs to?
Belongs to the MPEG1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles.
Protein: ASSY_STRSV
Sequence: MVKEKVILAYSGGLDTSVAITWLDKDYDVIAVCMDVGEGNDLDFIHDKALKVGAIESHVIDVKDEFAEDYVLVALQGHTFYERKYPLVSALSRPLISKKLVEIAHKTGATTIAHGCTGKGNDQVRFEVAIASLDPKLKVIAPVREWKWSREEEINYAKANGVPIPADLDSPYSVDQNLWGRANECGVLENPWNEAPEDAYDLTVAPEAAPDSPVYVNIDFEAGVPVALDGKKMKLADLILELNDLAGQHGVGRIDHVENRLVGIKSREIYECPGAVTLLAAHKEIEDLTLVRELAHFKPIIENELSNLIYNGLWFNPATEALIAYLKSTQQVVNGTAKVKLYKGAATVVARKSDNSLYDESLATYTSADTFDQDAAIGFIKLWGLPSKVHAEVQAHKDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D107A_MACFA
Sequence: MKIFFFIFAALILLAQIFQARTAIHRALICKRMEGHCEAECLTFEVKIGGCRAELTPYCCKKRKKD
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 107A, Defensin, beta 107, Defensin, beta 107A.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSTT_YERPN
Sequence: MEKTQSVFIRFIVNGSLVKQILIGLVAGIVLALVSTPAAIAVGLLGSLFVGALKAVAPVLVLMLVIASIANHKKGQKTSIRPILFLYVLGTFSAALVAVVVSFIYPSTLILVAESADITPPSGIVEVLHGLLNSIIANPIHALLNANYIGILAWAVGLGIALRHAADTTKALINDMSDAVTLVVRVVIRFAPLGIFGLVASTIAATGFGALQLYAQLLVVLIGCMLLVALVVNPLIVYWKIRRNPYPLVFACLRESGVTAFFTRSSAANIPVNMEMCKKMNLNEDTYSISIPLGATINMAGAAITITVLTLAAVHTLGITVDLPTALLLSVVAAICACGASGVAGGSLLLIPLACSMFGIPNDVAMQVVGVGFIIGVLQDSAETALNSSTDVLFTAAVCQAEDAKLANPDPLAAGKSV
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DKK3_CHICK
Sequence: MRRGEGPAPRRRWLLLLAVLAALCCAAAGSGGRRRAASLGEMLREVEALMEDTQHKLRNAVQEMEAEEEGAKKLSEVNFENLPPTYHNESNTETRIGNKTVQTHQEIDKVTDNRTGSTIFSETIITSIKGGENKRNHECIIDEDCETGKYCQFSTFEYKCQPCKTQHTHCSRDVECCGDQLCVWGECRKATSRGENGTICENQHDCNPGTCCAFQKELLFPVCTPLPEEGEPCHDPSNRLLNLITWELEPDGVLERCPCASGLICQPQSSHSTTSVCELSSNETRKNEKEDPLNMDEMPFISLIPRDILSDYEESSVIQEVRKELESLEDQAGVKSEHDPAHDLFLGDEI
What is the function of this protein?
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6.  DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.  In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
What are the official names of this protein?
Dickkopf-related protein 3, Dickkopf-3, Dkk-3, Lens fiber protein CLFEST4.
What is the protein family that this protein belongs to?
Belongs to the dickkopf family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPPH_NEIMB
Sequence: MLDREGYRPNVGIILINNRNEVFWGKRVREHSWQFPQGGIKPGESPETAMYRELYEEVGLLPQHVKIIGRTRDWLRYDVPNNWVRREWRGSYRGQKQIWYLLRLTGRDCDVNLRATRHPEFDGWRWHQYWAPVDEVIDFKRDVYLGALKELSSRFLRGMESYEDFAARQSSDNR
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: YBEY_RICRO
Sequence: MINVEIVRHYNKWREHKQINKSLIKKITQNILLRFDNFSKIKQFELSILLTNAAEILILNKQFRNIEKATNVLSFPSNELNWQDLYSKLEFLGDSDYMHLGDIAFCYEVIYNESCEQHKTFENHFIHLLIHSILHLIGFDHQNDTEANIMENLEIEILSYFGIFPPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOC1_NEUCR
Sequence: MAPTKTIKNKHAANKSGIKGSKDAERSRNDGVLKSKGKPKGKAHTLVTASKGRPNIQELIARKKKKKTYSEKELAIPELNMITPVGVTKPKGKKKGKVFVDDKESMATILAIVQAEKEGQIESKMIKARQMEEIREARRAEAEKKEAERKARLEETKDSLRKKRKRSKQSGGSKGDDDDDSRDVKEFSSAGTKAVKSKKKKSVSFAAPE
What is the function of this protein?
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal subunit assembly/export protein loc-1.
What is the protein family that this protein belongs to?
Belongs to the LOC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SHH_DANAP
Sequence: YGRRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.  Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes.  Displays floor plate-inducing activity.  Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.  In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).
What are the official names of this protein?
Sonic hedgehog protein, SHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Secreted. Cell membrane. Note=Sonic hedgehog protein C-product: Secreted, extracellular space. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor. The C-terminal peptide diffuses from the cell, while the N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside.
Protein: ALB1_SOYBN
Sequence: MAVFLLATSTIMFPTKIEAADCNGACSPFEVPPCRSRDCRCVPIGLFVGFCIHPTGLSSVAKMIDEHPNLCQSDDECMKKGSGNFCARYPNNYIDYGWCFDSDSEALKGFLAMPRATTK
What is the function of this protein?
A1b binds to basic 7S globulin (BG) and stimulates its phosphorylation activity.  Involved in the signal transduction system to regulate the growth and differentiation as a hormone peptide.
What are the official names of this protein?
Albumin-1, A1.
Protein: APY_AEDAE
Sequence: MAGRPGYSEVIFLYVVSVAVIARATDNMPVNKDVSKLFPLTLIHINDLHARFEETNMKSNVCTQKDQCIAGIARVYQKIKDLLKEYESKNPIYLNAGDNFQGTLWYNLLRWNVTADFIKKLKPAAMTLGNHEFDHTPKGLAPYLAELNKEGIPTIVANLVMNNDPDLKSSKIPKSIKLTVGKRKIGIIGVLYDKTHEIAQTGKVTLSNAVEAVRREAAALKKDNIDIIVVLSHCSYEEDKKIAAEAGDDIDVIVGAHSHSFLYSPDSKQPHDPKDKVEGPYPTLVESKNKRKIPIVQAKSFGKYVGRLTLYFDEEGEVKNWEGYPVFIDHKVQQDPQILKDLVPWRAKVEAIGSTVVGETMIELDRDSCRDQECTLGVLYADGFADQYTNDTFRPFAIIQAGNFRNPIKVGKITNGDIIEAAPFGSTADLIRLKGADIWDVAEHSFALDDEGRTNCLQVSGLRIVIDISKPVRSRVKKIEVMDYTNPKSDKLKPLDKEAEYYIVVPSYLADGKDGFSAMKRATARRTGPLDSDVFKNYVEKIKKVDNLKLGRVIVCKGSKCT
What is the function of this protein?
Facilitates hematophagy by preventing ADP-dependent platelet aggregation in the host.  May reduce probing time by facilitating the speed of locating blood.
What are the official names of this protein?
Apyrase, ATP-diphosphatase, ADPase, ATP-diphosphohydrolase, Adenosine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NANT_SALA4
Sequence: MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSQVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFCFAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGAVPLGSGKGAFVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OTX5B_XENLA
Sequence: MMSYIKQPHYAVNGLTLAGTGMDLLHSAVGYPTNPRKQRRERTTFTRAQLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQSTGQAKPRPAKKKTSPARETNSEASTNGQYSPPPPGTAVTPSSSASATVSIWSPASISPIPDPLSAVTNPCMQRSTGYPMTYSQAPAYTQSYGGSSSYFTGLDCGSYLSPMHPQLSAPGATLSPIATPTMGSHLSQSPASLSAQGYGAASLGFTSVDCLDYKDQTASWKLNFNATDCLDYKDQSSWKFQVL
What is the function of this protein?
Transcription factor involved in anterior and eye development.  Promotes the differentiation of both rod and cone photoreceptors cells in the retina.  Together with other retinal homeobox proteins, acts as an effector of a cellular clock which, depending on cell cycle progression, establishes the generation of distinct retinal neuronal cell types.  Acts synergistically with nrl to activate the rhodopsin promoter.  Promotes the formation of anterior regions and represses the formation of posterior structures during development.
What are the official names of this protein?
Homeobox protein otx5-B, Orthodenticle homolog 5-B, XOtx5b.