PharMolix/UniProtQA huggingface dataset:
Protein: SUCC_SALTY
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVKSKEEIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIGKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDNVKAVLVNIFGGIVRCDLIADGIIGAVEEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKSLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: LPXC_BURP1
Sequence: MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDTRLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFKLKFTIDFRHPAVDKTGQELEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKMLDAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDAQTAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RAPA_ESCF3
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSNSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: DSBA_SHIFL
Sequence: MKKIWLALAGLVLAFSASAAQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNFMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEEK
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA.  Acts by transferring its disulfide bond to other proteins and is reduced in the process.  DsbA is reoxidized by DsbB.  It is required for pilus biogenesis.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbA.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbA subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: LAP4A_PONAB
Sequence: MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA
What is the function of this protein?
May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
What are the official names of this protein?
Lysosomal-associated transmembrane protein 4A.
What is the protein family that this protein belongs to?
Belongs to the LAPTM4/LAPTM5 transporter family.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein. Note=May reside in an intracellular membrane-bound compartment.
Protein: RS18_EHRRG
Sequence: MLKKGKKTGSNSSGGTAYSPLAYLKRPYFRRSKACPLEQCANEDIDYKNKALLSKFTSEYGRILPSRITSVSSRKQRLLSTAIKRARYLALLPYC
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: 3SOF2_NAJME
Sequence: IKCHNTLLPFIYKTCPEGQNLCFKGTLKFPKKTTYNRGCAATCPKSSLLVKYVCCNTNKCN
What is the function of this protein?
Has low cytotoxic activity.
What are the official names of this protein?
Cytotoxin homolog 2, Cytotoxin homolog V-II-2/V-II-3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group XV sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: TPX2_BOVIN
Sequence: MSQVTTSYSYDAPTDFINFSSLTDEEDMQHIDSWFDEKANLENKFTGKDGTGGLYQGKTPLRKANLHRDVTPLRPVDNTYNKQAEKENLVEESIPSNECPSMKVKETTSRNNPVQPQRRSLRLSAKKNLEQKEKQHVKMKAKRCGTPVIINEFPPSKKMKVQKILKSTEEQELEKRMKMQQEVVEMRKRNEEFKKFALAGAGQPVKKSVSQVTKAVDFHFRTDERVKQHPKNQEEYKEVNFTSELRKHPPSPARVTKGCTIVMPFNLSQGKKRTFDETASTYVPLAQQVEAFHKRTPTRYHLRNRKDDIMPLPSKSVVRICRDPQTPVLQTKHRTRPVTCKSAADLEAEELEKQQQYKFKAQELDPRILEGGPILPKKPPVKPPTQPVGFDLEIEKRIQERESKKKLEEEHYEFHSRPCPTKILEDVVGVPEKKELPITVPKSPAFALKNRIRMPTKEDKEEEEPVMIRAQPVPYFGMPFKPQIPVGRTVEVCPFSFDSRDKERQLQKEKKIKELQKGEVPKFKAHPLPHFDTINLPEKKVKNTTQVEPFCLETDRRGALKAQTWKHQLDEELKQQKEAACFKARPNTVISQEPFVPKREKKSVIEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEALKAQQLEEARQQEEEQQKEELARLRKELVHKANPIRRYQGVEVKSSDQPLTVPVSPKFSTRFHC
What is the function of this protein?
Spindle assembly factor required for normal assembly of mitotic spindles.  Required for normal assembly of microtubules during apoptosis.  Required for chromatin and/or kinetochore dependent microtubule nucleation.  Mediates AURKA localization to spindle microtubules.  Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.  TPX2 is inactivated upon binding to importin-alpha.  At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
What are the official names of this protein?
Targeting protein for Xklp2.
What is the protein family that this protein belongs to?
Belongs to the TPX2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Protein: ATP6_BRUSU
Sequence: MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSKGMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMYINDAVHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADE_CHESB
Sequence: MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFRTQEDYALLAETYLKELAAGGAIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGIESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGDERAGHPRDFAYAFDIAREAGLGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVVLKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITSTAIEAAFVDEKTRAALFARLKPVVES
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: NMNA1_MOUSE
Sequence: MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL
What is the function of this protein?
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:15381699, PubMed:27735788).  Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity).  Can use triazofurin monophosphate (TrMP) as substrate (By similarity).  Also catalyzes the reverse reaction, i. e.  the pyrophosphorolytic cleavage of NAD(+) (By similarity).  For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity).  Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity).  Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity).  Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity).  Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (PubMed:32822587).  Protects against axonal degeneration following mechanical or toxic insults (PubMed:15310905, PubMed:16914673).  Delays axonal degeneration after axotomy.  Results in a >10-fold increase in intact neurites 72 hours after injury (PubMed:16914673, PubMed:27735788).
What are the official names of this protein?
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, NMN/NaMN adenylyltransferase 1, Nicotinamide mononucleotide adenylyltransferase 1, NMN adenylyltransferase 1, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_AMOA5
Sequence: MALNKEDKKDIFLTYSAKNVAQDTGSPESQIALFSNRITYLTEHLKQYPKDKASRLGLIKLVGKRKKQLTYLQNTAIERYRDIIVKLGIRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PGLR2_ARATH
Sequence: MVGSHKASGVLLVLLVVMATTIANGTPVVDKAKNAATAVEDTAKNAATAVGGAAASVGAKVSGAKPGAAVDVKASGAKGDSKTDDSAAFAAAWKEACAAGSTITVPKGEYMVESLEFKGPCKGPVTLELNGNFKAPATVKTTKPHAGWIDFENIADFTLNGNKAIFDGQGSLAWKANDCAKTGKCNSLPINIRFTGLTNSKINSITSTNSKLFHMNILNCKNITLSDIGIDAPPESLNTDGIHIGRSNGVNLIGAKIKTGDDCVSIGDGTENLIVENVECGPGHGISIGSLGRYPNEQPVKGVTVRKCLIKNTDNGVRIKTWPGSPPGIASNILFEDITMDNVSLPVLIDQEYCPYGHCKAGVPSQVKLSDVTIKGIKGTSATKVAVKLMCSKGVPCTNIALSDINLVHNGKEGPAVSACSNIKPILSGKLVPAACTEVAKPGP
What is the function of this protein?
May function in depolymerizing pectin during pollen development, germination, and tube growth.  Acts as an exo-polygalacturonase.
What are the official names of this protein?
Exopolygalacturonase clone GBGA483, ExoPG, Galacturan 1,4-alpha-galacturonidase, Pectinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: PYRH_LEPBL
Sequence: MGSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKVGIDRATADYMGMLATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKATKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSEDIQIDGK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTMC1_METBA
Sequence: MANQEIFDKLRDAIVNQNVAGTPELCKEALAAGVPALDIITKGLSVGMKIVGDKFEAAEIFLPQIMMSGKAMSNAMEVLTPELEKNKKEGEEAGLAITFVAEGDIHDIGHRLVTTMLGANGFQIVDLGVDVLNENVVEEAAKHKGEKVLLVGSALMTTSMLGQKDLMDRLNEEKLRDSVKCMFGGAPVSDKWIEEIGADATAENAAEAAKVALEVMK
What is the function of this protein?
Acts as a methyl group carrier between MtmB and MtbA.
What are the official names of this protein?
Monomethylamine corrinoid protein 1, MMCP 1.
What is the protein family that this protein belongs to?
Belongs to the methylamine corrinoid protein family.
Protein: ATPL_MYCPU
Sequence: MENIISLLALKNDPTSATTGAGLVAVGAGLASIGNFGTGLGQGLSAGRAAEAVGRNPEAIKKIRSLMIIGMAISESASLYSFIIAILLVFVY
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNTH_ECOLU
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACT10_SOLTU
Sequence: AGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDHLMKILTERGYSFTTTAEREIVRDVK
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-85C.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: IER2_HUMAN
Sequence: MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVEALEPEVSLPAALPSDPRLHPPREAESTAETATPDGEHPFPEPMDTQEAPTAEETSACCAPRPAKVSRKRRSSSLSDGGDAGLVPSKKARLEEKEEEEGASSEVADRLQPPPAQAEGAFPNLARVLQRRFSGLLNCSPAAPPTAPPACEAKPACRPADSMLNVLVRAVVAF
What is the function of this protein?
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537).  Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity).  May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity).  Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
What are the official names of this protein?
Immediate early response gene 2 protein, Protein ETR101.
What is the protein family that this protein belongs to?
Belongs to the IER family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.
Protein: DPO3A_AQUAE
Sequence: MSKDFVHLHLHTQFSLLDGAIKIDELVKKAKEYGYKAVGMSDHGNLFGSYKFYKALKAEGIKPIIGMEAYFTTGSRFDRKTKTSEDNITDKYNHHLILIAKDDKGLKNLMKLSTLAYKEGFYYKPRIDYELLEKYGEGLIALTACLKGVPTYYASINEVKKAEEWVKKFKDIFGDDLYLELQANNIPEQEVANRNLIEIAKKYDVKLIATQDAHYLNPEDRYAHTVLMALQMKKTIHELSSGNFKCSNEDLHFAPPEYMWKKFEGKFEGWEKALLNTLEVMEKTADSFEIFENSTYLLPKYDVPPDKTLEEYLRELAYKGLRQRIERGQAKDTKEYWERLEYELEVINKMGFAGYFLIVQDFINWAKKNDIPVGPGRGSAGGSLVAYAIGITDVDPIKHGFLFERFLNPERVSMPDIDVDFCQDNREKVIEYVRNKYGHDNVAQIITYNVMKAKQTLRDVARAMGLPYSTADKLAKLIPQGDVQGTWLSLEEMYKTPVEELLQKYGEHRTDIEDNVKKFRQICEESPEIKQLVETALKLEGLTRHTSLHAAGVVIAPKPLSELVPLYYDKEGEVATQYDMVQLEELGLLKMDFLGLKTLTELKLMKELIKERHGVDINFLELPLDDPKVYKLLQEGKTTGVFQLESRGMKELLKKLKPDSFDDIVAVLALYRPGPLKSGLVDTYIKRKHGKEPVEYPFPELEPVLKETYGVIVYQEQVMKMSQILSGFTPGEADTLRKAIGKKKADLMAQMKDKFIQGAVERGYPEEKIRKLWEDIEKFASYSFNKSHSVAYGYISYWTAYVKAHYPAEFFAVKLTTEKNDNKFLNLIKDAKLFGFEILPPDINKSDVGFTIEGENRIRFGLARIKGVGEETAKIIVEARKKYKQFKGLADFINKTKNRKINKKVVEALVKAGAFDFTKKKRKELLAKVANSEKALMATQNSLFGAPKEEVEELDPLKLEKEVLGFYISGHPLDNYEKLLKNRYTPIEDLEEWDKESEAVLTGVITELKVKKTKNGDYMAVFNLVDKTGLIECVVFPGVYEEAKELIEEDRVVVVKGFLDEDLETENVKFVVKEVFSPEEFAKEMRNTLYIFLKREQALNGVAEKLKGIIENNRTEDGYNLVLTVDLGDYFVDLALPQDMKLKADRKVVEEIEKLGVKVII
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFM6_YEAST
Sequence: MESIFGGFGDLVVPRPKEHLGQTDLSFGGKLLPALKICEDGGESGCGGKVWIAGELLCEYILEKSVDHLLSKTVNGTKQFKKVLELGSGTGLVGLCVGLLEKNTFHDGTKVYVTDIDKLIPLLKRNIELDEVQYEVLARELWWGEPLSADFSPQEGAMQANNVDLVLAADCVYLEEAFPLLEKTLLDLTHCINPPVILMAYKKRRKADKHFFNKIKRNFDVLEITDFSKFEHYLKERTHLFQLIRK
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-390'.
What are the official names of this protein?
Protein-lysine N-methyltransferase EFM6, Elongation factor methyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_DESAL
Sequence: MASSVWQTELPDLPEPKRGKVRDMYDLGDAYLMVATDRLSAFDVIMPDPIPDKGKVLTQISLFWFDVMKDIVDNHVLTAKVDEFPVKCRQYADILEGRSILVKKVQPQAIECVVRGYISGSGWSSYKKSQSVCGISLPEGLKESEKLPKTLFTPSTKAELGEHDENISFEKAAEIVGPETAEKLRDLSLAIYTKGADLANEKGIIIADTKFEFGTTDDGRIILIDEVLTPDSSRFWPKDQYEPGRAQDSFDKQFVRDYLLEIKFNKQPPGPKLPQEVLDKTRDKYLQALKLLAGDAYSI
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: GCST_PHOLL
Sequence: MAKQTPLYDQHLACGARMVDFHGWMMPLHYGSQMDEHHIVRTHAGMFDVSHMTIVDLHGTGCRDFLRYLLANDIAKLTEKGKALYTGMLNASGGVIDDLIVYYLSNDFYRLVVNSATREKDLAWINEHVANYPVDIQVRDDLALIAVQGPDAQAKVESLLNDEQKQTIAGMKPFFGVQAGDLFIATTGYTGEAGYEVALPKEQAADFWQKLLSVGVKPAGLGARDTLRLEAGMNLYGQEMDETISPLVANMGWTIAWKPEDRQFIGREALEKQREEGTEQLVGLVMREKGVLRGGLAVSFTDEMGTLHSGVITSGTFSPTLGFSIALARVPQGIGEQAVVQIRNREMPVQVVKPSFVRAGKPLV
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: TBX34_CAEEL
Sequence: MQVSIVNEHKYRELEPLNEMLVKRGGVKMIPEPKFVISGLVDNEEYVIKLRIDLADEFRYSYQNQQWTPFAPSTKNSKLSAITETEHRKETGATWNMRIVQFDKLLITREFNDIQRNVIHVEPNHKYIPVLTIQNVTTGKSTEFQFQQMEFIAVKSYQSARIRHTKRAPRKMNLAPGSSQKPQLIVPDILHSPTYGFTAAPPPFPFEYWLLYPQIQYQIQQLAYSLPMGPPMVPIHHIQCTEASQRVYAPEYGWNSILMPGAHKEQDDHYMFHHEIWAPQDHELEKLHVLTEQKNKPSETPQ
What are the official names of this protein?
Putative T-box protein 34.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRF_SORC5
Sequence: MLEDVIKELREGIEKAIEALRRDLAKVRTGRANAAMLDGIRVDYYGVPTPIVQMATVSVPEPRLISVKPWEKNQVKAIEKAIRESDLGLNPQVDADLIRLPIPPLTEERRREMVKLTKKNGEDCKVAIRKHRRDANEMIDSLEKDGDVSGDEADRAKKKVDDVVAEGTKLVDTVIAGKEKDILDV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_CLOTE
Sequence: MEKDIKILAIESSCDETSAAVVINGREVLSNVISSQIDIHEKFGGVVPEVASRKHIEAISLVVQEAIKEANMDYEELDAIAVTYGPGLVGALLVGLQYAKGLSYALNKPLIGVNHIEGHISANYIQHKDLEPPFLCLVVSGGNTFIVYVENYGEYEIIGETRDDAAGEAYDKVARAIGLGYPGGPKIDKLAKEGNENAIKFPRAKFHEENTLDFSFSGLKSSVLNYLNTMEMKKEEINRADVAASFQKAVVDFLVDNTMKAAKIKKVDEIAVAGGVAANSCLRDTIVKEGEKNNIKILFPSIKLCTDNAAMIGSAAYFQFLKSDFSDLNLNAVPNLKLNK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.