PharMolix/UniProtQA huggingface dataset:
Protein: AP2B_MOUSE
Sequence: MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTNRHTSGEGPGSKTGDKEEKHRK
What is the function of this protein?
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes.  AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.  They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.  AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
What are the official names of this protein?
Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta.
What is the protein family that this protein belongs to?
Belongs to the AP-2 family.
What are the subcellular locations of this protein?
Nucleus. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum.
Protein: TMM71_HUMAN
Sequence: MYRISQLMSTPVASSSRLEREYAGELSPTCIFPSFTCDSLDGYHSFECGSIDPLTGSHYTCRRSPRLLTNGYYIWTEDSFLCDKDGNITLNPSQTSVMYKENLVRIFRKKKRICHSFSSLFNLSTSKSWLHGSIFGDINSSPSEDNWLKGTRRLDTDHCNGNADDLDCSSLTDDWESGKMNAESVITSSSSHIISQPPGGNSHSLSLQSQLTASERFQENSSDHSETRLLQEVFFQAILLAVCLIISACARWFMGEILASVFTCSLMITVAYVKSLFLSLASYFKTTACARFVKI
What are the official names of this protein?
Transmembrane protein 71.
What is the protein family that this protein belongs to?
Belongs to the TMEM71 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: 3S12_HYDHA
Sequence: MKTLLLTLVVVTIVCLDLGYTMTCCNQQSSQPKTTTNCAESSCYKKTWSDHRGTRIERGCGCPQVKHGIKLECCHTNECNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 2, SN36.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSD_PSEA6
Sequence: MTSSIPNVTHLKQLEAESIHIFREVAAEFDNPVMLYSVGKDSSVLLHLARKAFAPGKIPFPLLHVDTTWKFHEMIAFRDQMADKHDLDLLVHINQEGVDMDINPFIHGSAKHTDIMKTVGLKQALNKYKFDAAFGGARRDEEKSRAKERVYSFRDENHRWDPKNQRPELWSIYNSQINKGESIRVFPMSNWTELDIWQYIYMENIEIPSLYLAKPRPVVERDGLLIMVDDERMPLEEGETPEMRSVRFRTLGCYPLTGAVESTANTLPEVIQEMLLTKTSERQGRVIDNDSSGSMEKKKMEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: HIS52_LEGPL
Sequence: MIAVIDVSGNNLTSLTNALIRLGGHFALTHDAQEIQKASHVILPGVGTARSGMTALQQNGLIDVLRTLTQPLLGICLGMQLLLEYSEEDDIPCLGLIPGVAELLKAERNHPVPHMGWNNLHWQKTSSLQQGLNNSDYVYFVHSYALKADDYALARCRYHEEFTAVVKKGNFYGMQFHPEKSADVGMVLLNNFLSLESKC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH 2, IGP synthase glutaminase subunit 2, IGP synthase subunit HisH 2, ImGP synthase subunit HisH 2, IGPS subunit HisH 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_YERPB
Sequence: MPKIKTVRGAAKRFKKTANGGFKRKHANLRHILTKKATKRKRHLRPKGLVSKNDLGLVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ZN575_MOUSE
Sequence: MLGGSVKSEVRASEPSPTCQDPETKAPHQDLPRPNQPAASGSVPSRPRRRPPPQRPHRCPDCPKAFSYPSKLATHRLAHGGTRPHPCPDCPKAFSYPSKLAAHRLTHSGARPHSCPHCPKAFGHRSKLAAHLWTHAPARPYPCPDCPKSFCYPSKLAAHRHTHHATDARPYPCPHCPKAFSFPSKLAAHRLCHDPPTAPSSQATGSHRCSSCNQAFGQRRLLLVHQRSHHQSEGQGERE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 575.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURA_ASPFC
Sequence: MGITIVLGSQWGDEGKGKITDMLSQQATLCCRAAGGHNAGHTIVHENITYDFHILPSGLVSPSCVNLIGAGTVVHVPSFFKELASLEEKGLKDAGKRIFISDRAHVCFDLHSIVDGLEEAKLGGRKVGTTGKGIGPCYSDKAARRGVRIGEVLDEAVFERKLRSLHAGYTARFGELQYDVEEEIGRFKDYRKRLVPYIVDQLAFFKQYKDSPNTLVEGANALMLDLDHGTYPYVTSSSTGLGGAVQALSLNPTSITSVIGVVKAYTTRVGSGPFPSEQLNEYGDKLQSVGREFGVTTGRRRRCGWFDLVLCRYSQAINHYTALNLTKLDILDDFDEIKVAVAYVLPDGTRLTDTYPADPEVLEKVKVEYVTLPGWKSNTMGVKKYEDLPANARAYIEYIERELGGVPIKWIGTGPARDHMICRE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2C1_PANTR
Sequence: MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGSGIGGGGFGGFGSGGGGFGGGGFGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELNNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVGVSVSTSHTTISGGGGRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR
What is the function of this protein?
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta 1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1).  In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 1, Cytokeratin-1, CK-1, Keratin-1, K1, Type-II keratin Kb1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm.
Protein: Y1444_BRUC2
Sequence: MAQGDDNKQAIGQIIRQEQALIFPSLNENDAFSLGQRIRDIAVKDKLGIAIDISLWDRRLFFAATAGATADNTEWLRRKFNVVRRFHVSTYRLVLEQNREDRMFAPYKALDVADYALAGGGFPIRVSGAGVIGAVIVSGLPQREDHNLVVRAVAEHVGQDPVALALPAA
What are the official names of this protein?
UPF0303 protein BCAN_A1444.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: BIOF_XYLFT
Sequence: MTRPDLNERILSLRKLRLAQCRTRTRRTIERRNGVRLEINGSWLVEFCSNDYLGLAQHFEIIAALQDAAARNGIGATASHLICGHHAIHKALEYELAEWLGYPRALLFGSGFTANLAVQQALLTKENDICVQDRLNHASLIDATRLAGCRLRRYPHLDVDGAAHQLKNAPEGAAMLATDGIFSMDGDIAPLRALSLVARTQQALMYVDDAHGIGVTGPQGRGCIAAAWLSVEEVPLQLVTLSKALGGYGAAVLGSATLIQHLAETARPYIYTTALPPAQAAAALTAIRIARRDEWRRQRLQELVERFRENSRRHGLEIMDSETPIQPLQCGDETTTMAMSAALEREGFLVNAIRPPTVPEGKSRLRVTLSALHTTEQIDTLVQALARSRDALATEAAPVKV
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: Y990_STRM5
Sequence: MLLHIPDILSADQVADFRRRLDAADWTDGRETVGHLGAQAKHNQQLPEASPLRRELGEIILVALARHPLFFSAALPLKYLPPRFNRYSGGGTYGFHVDGAVMNLANGEQLRSDISCTLFLSAPDEYEGGELIISDTYGEHEVKLPAGDLIVYPSSSLHQVRPVTAGARVASFFWVQSMVRDDVQRRLLWEMDGSIERLRQTGGDAEAVLQLTGVYHNLLRRWSEV
What are the official names of this protein?
PKHD-type hydroxylase Smal_0990.
Protein: AZOR_BURP1
Sequence: MTTILQINSAARSQGAQSTLLADELTAKLQQGNPGATVKVRNLLADALPHLDDAVLGAFFTPADQRSAEQNAIVAKSDELVDELRSADVIVIGAPMYNFGVSSQLKAYFDWIARAGVTFRYTSEGPEGLIKGKKAYVVSARGGKHVGMPTDSQTPFLKTFLGFIGLTDVTFVYAEGLALGPDAATEALASAREAIAAV
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: ACPS_ACICJ
Sequence: MIIGIGSDLCDIRRVERTLERFGERFIQRVFTETERRRAARRPAQFAATLAKRFAAKEACAKALGTGFRRGVFMSDLGVVNLPSGQPTLALTGGAAERLAALTPPGRSAFVHLSLTDEYPYAYAHVIIEARDGA
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXB_ECO27
Sequence: MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGAQAIQLGANHVWKLSGKPDDRMIEDYADVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLNAAVSNDASAVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDVAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQFADYGIVGDAVKILPALTAALAR
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixB.
What is the protein family that this protein belongs to?
Belongs to the ETF alpha-subunit/FixB family.
Protein: SPTB2_CAPHI
Sequence: VLLLSQDYGKYKEVAELTRTQILAASYELHK
What is the function of this protein?
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.  Plays a critical role in central nervous system development and function.
What are the official names of this protein?
Spectrin beta chain, non-erythrocytic 1.
What is the protein family that this protein belongs to?
Belongs to the spectrin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.
Protein: RAV2_ARATH
Sequence: MDSSCIDEISSSTSESFSATTAKKLSPPPAAALRLYRMGSGGSSVVLDPENGLETESRKLPSSKYKGVVPQPNGRWGAQIYEKHQRVWLGTFNEQEEAARSYDIAACRFRGRDAVVNFKNVLEDGDLAFLEAHSKAEIVDMLRKHTYADELEQNNKRQLFLSVDANGKRNGSSTTQNDKVLKTREVLFEKAVTPSDVGKLNRLVIPKQHAEKHFPLPSPSPAVTKGVLINFEDVNGKVWRFRYSYWNSSQSYVLTKGWSRFVKEKNLRAGDVVTFERSTGLERQLYIDWKVRSGPRENPVQVVVRLFGVDIFNVTTVKPNDVVAVCGGKRSRDVDDMFALRCSKKQAIINAL
What is the function of this protein?
Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).  Transcriptional repressor of flowering time on long day plants.  Acts directly on FT expression by binding 5'-CAACA-3' and 5'-CACCTG-3 sequences (Probable).  Functionally redundant with TEM1.
What are the official names of this protein?
AP2/ERF and B3 domain-containing transcription repressor RAV2, Ethylene-responsive transcription factor RAV2, Protein RELATED TO ABI3/VP1 2, Protein RELATED TO APETALA2 8, Protein TEMPRANILLO 2.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. RAV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBN_ILLOL
Sequence: METATLVAISISGSLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PURA_SORC5
Sequence: MTAIVIVGAQWGDEGKGKVVDLYTESADLVVRYAGGPNAGHTLVVGGEKLIVRLIPSGILRSNARCVMAQGMVVDPGVLVSEIDAVEARGCSTQGRLFVSDRAHLILPFHPLVDSLREAAAADGVRLGTTKRGIGPCYEDKASRRGARLGDLRDMKRLAQLVSRSLEAWTPTLRALGGEPPSLDAILDELTPLAKRITPLLADTSQLIDGALRRGERVLLEGAQGTLLDIDHGTFPFVTSSSAIAGGACVGAGVGPTRIRRVLGLAKAYCTRVGEGPFPTELDGPLGERLRSVGGEYGSVTGRPRRTGWLDLPALRYAARVNGLDGIALTKLDVLTGMPELKVCVAYDTPSGRTREFPIDDIATAKPVLETVAEWSEPIDAARSMTELPAAARHYVEMVEKETGVPVDVVSVGADREATIVRRNAFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_SHEB2
Sequence: MAELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDELGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPMALHMLLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLRYMQKIIDGLTRFADGRKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVGHILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKRYHK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_RUMCH
Sequence: MGRRASRETAMKLLYQLEIQKTDRDEQINMALEDESLTKNDREYIKGIVDGVYEKTPVLDGIIEKKATGWKINRLSKIDLSVLRIGIYEILYRDDIPFSVSVNEAVELAKKYSNEDAGAFVNGLLAKVSKGDLPQETSANEVDSQ
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PRK3_ARATH
Sequence: MTAVLFLCFLLICFSFTPSLQNVSESEPLVRFKRSVNITKGDLNSWRTGTDPCNGKWFGIYCQKGQTVSGIHVTRLGLSGTINIEDLKDLPNLRTIRLDNNLLSGPLPPFFKLPGLKSLLLSNNSFSGEIADDFFKETPQLKRVFLDNNRLSGKIPASLMQLAGLEELHMQGNQFTGEIPPLTDGNKVLKSLDLSNNDLEGEIPITISDRKNLEMKFEGNQRLCGSPLNIECDEKPSSTGSGNEKNNTAKAIFMVILFLLIFLFVVAIITRWKKKRQPEFRMLGKDHLSDQESVEVRVPDSIKKPIDSSKKRSNAEGSSKKGSSHNGKGAGGGPGSGMGDIIMVNSEKGSFGLPDLMKAAAEVLGNGSLGSAYKAVMANGLSVVVKRIRDMNKLAREAFDTEMQRFGKLRHPNVLTPLAYHYRREEKLVVSEYMPKSSLLYVLHGDRGVYHSELTWATRLKIIQGVARGMDFLHEEFASYDLPHGNLKSSNVLLSETYEPLISDYAFLPLLQPNNASQALFAFKSPEFVQNQQVSPKSDVYCLGIIVLEVMTGKFPSQYLNTGKGGTDIVEWVQSSIAQHKEEELIDPEIASNTDSIKQMVELLRIGAACIASNPNERQNMKEIVRRIERVTL
What is the function of this protein?
Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth (PubMed:23024212).  Can phosphorylate ROPGEF1 in vitro (PubMed:23024212).
What are the official names of this protein?
Pollen receptor-like kinase 3, AtPRK3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RAPZ_PROMH
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVDLLPELAKTLAERDAAAAAVSIDVRNMPESPEIFEKALESLPAEYSPQLLFLDADRNTLIRRYSDTRRLHPLSTKNLSLEMAIDTESDLLEPLRSRADLIIDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDRPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYVAEQLADYFRSRGKNVQSRHRTLEKRK
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: CDK7_HUMAN
Sequence: MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
What is the function of this protein?
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.  Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle.  Each different complex controls a specific transition between 2 subsequent phases in the cell cycle.  Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation).  CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex.  Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.  CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression.  CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112).  Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA.  Its expression and activity are constant throughout the cell cycle.  Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis.  Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
What are the official names of this protein?
Cyclin-dependent kinase 7, 39 kDa protein kinase, p39 Mo15, CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173).
Protein: IF2_POLNA
Sequence: MSSTTTVAEFAAELNKSPATLIEQLTSAGVAKVQASDPLSESDKQKLLGYLHASHGTVAADRKKITLVKKSTSEIKQADSTGRARIIPVQTIKKRTFIKRDDGSDMPVEEAQPEVLVAPQVQAAADAELVRREDEANRHAELLRRQEAELTEKRRLRDEQAAQEAAREREREAAAQKAQAEAVAQAAAAAQAAALAAEAAKKVKPTIGKIFKPAPVAPTAPAITVEAQKVIDTAAAEKTSKAAEAATAKAAETASLQAAAKAKATAEFQADAAKAVDLQERRRKAEAEAAGIRAMLSAPKRVLVPHVDPKIAMKGTLHKPVVAPGAAKPAVPAAAAPAAPGAAGKKEVKSENLSSTWKDDAAKKKGIPSRGAPVVPGRGNFRAGPRGRRSSGRDVRPESNFVAPTEFKVLEVHVPETITVSELAHKMSIKSSEVIKHLMKLGQMVTINQPLDQDTAMIVVEEMGHTALTAALDDPEAFTADDVQGQQAEALPRAPVVTVMGHVDHGKTSLLDYIRRAKVASGEAGGITQHIGAYHVQTPRGMVSFLDTPGHEAFTAMRARGAQATDIVILVVAADDGVMPQTKEAIKHARAAGVPIVVAINKIDKPGINLERVKGELVTEGVVPEEFGGDSPFVPVSAHTGAGIDDLLEQVLLQAEVLELKASVDSLAKGLVIEARLDKGRGPVATVLVQSGTLKAGDVVLAGSTYGRVRAMLDENGKPIKTAGPSIPVEIQGLTEVPQAGDDFMVMTDERRVREIATYRAGKFRNTKLAKQQASKLENMFSDINAGEVKMLPIIIKADVQGSQEALAQSLLKLSTDEVKVQLVYSGVGGISESDVNLAIASKAVLIGFNTRADAQARKQAENNGIDIRYYNIIYDAVDELKAAMSGMLTPDKKEEIIGNAEIRNIFKVSKIGSIAGCMVTAGVVRRTAKVRLLRGNVVIFTGELDSLKRFKDDAKEVKEGFECGLNLKNYNDIEVGDILEFFEIKEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.