PharMolix/UniProtQA huggingface dataset:
Protein: RL5_STRCO
Sequence: MATTTTPRLKTKYREEIAGKLREEFSYENVMQIPGLVKIVVNMGVGDAARDSKLIEGAIRDLTTITGQKPAVTKARKSIAQFKLREGQPIGAHVTLRGDRMWEFLDRTLSLALPRIRDFRGLSPKQFDGRGNYTFGLTEQVMFHEIDQDKIDRTRGMDITVVTTATNDAEGRALLRHLGFPFKEA
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: LPL_ECO57
Sequence: MTHIVRFIGLLLLNASSLRGRRVSGIQH
What is the function of this protein?
Involved in control of the biosynthesis of leucine.
What are the official names of this protein?
leu operon leader peptide, leu operon attenuator peptide.
Protein: PSAC_ADICA
Sequence: MAHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKANQIASAPRTEDCVGCKRCESACPTDFLSVRVYLGAETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RSP4_CAEEL
Sequence: MSRGGGGDRRAAPDINGLTSLKIDNLSYQTTPNDLRRTFERYGDIGDVHIPRDKYSRQSKGFGFVRFYERRDAEHALDRTDGKLVDGRELRVTLAKYDRPSDERGGRGGGGGRRRSRSPRRRSRSPRYSRSRSPRRSRSRTRSPPSRDRRDSPDRRDNSRSRSRSPPPREDGSPKERRSRSRSASRSPSRSRSNSR
What is the function of this protein?
May play a functionally redundant role in embryogenesis.
What are the official names of this protein?
Probable splicing factor, arginine/serine-rich 4, CeSC35, RNA-binding protein srp-2.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPR_HV1RH
Sequence: MEQAPEDQGPQREPYNEWTLELLEELKSEAVRHFPRLWLHSLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCQHSRIGITRQRRARNGASRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: ATPK_MOUSE
Sequence: MASLVPLKEKKLMEVKLGELPSWIMMRDFTPSGIAGAFRRGYDRYYNKYINVRKGSISGISMVLAAYVVFSYCISYKELKHERRRKYH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane.
What are the official names of this protein?
ATP synthase subunit f, mitochondrial, ATP synthase membrane subunit f.
What is the protein family that this protein belongs to?
Belongs to the ATPase F chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MLE_CAEEL
Sequence: MAPPSQDVLKEIFNLYDEELDGKIDGTQVGDVARAAGLKPTQAMVTKAAGQEFKRKGEKRLTFEEWLPMYEQLAKEKEQGTYADFYEGLKVFDKEETGKILAAELRHILLALGERLSADEADELLKGVEDGEGMVKYEDFIKKVLAGPFPDQD
What are the official names of this protein?
Myosin, essential light chain, Myosin light chain alkali.
Protein: C11B1_SHEEP
Sequence: MALWAKARVWMAGPWLSLHRARPLGTRASAAPKAVLPFEAMPRCPGNKWMRVLQIWKEQGSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQAESLHPQRMLLEPWLAYRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNARGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMFKSTVQLMFVPRRLSRWTSSSMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQALRQESLVAEARISENPQRATTELPLLRAALKETLRLYPVGITLERQVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPESYHPQRWLDRQGSGSRFPHLAFGFGMRQCLGRRVAEVEMLLLLHHVLKNFLVETLAQEDIKMVYRFILMPSTLPLFTFRAIQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids.  Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
What are the official names of this protein?
Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P450C11, Steroid 11-beta-hydroxylase, CYP11B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: MA8C_SCHJA
Sequence: EFTISFSSPVISTGQHIDVGDEDYHDGDDDVDYTDDVDDVDDSHGSPSQLLQGGYQRNQHYGGGNYQSGYYRPNKQHGNGYGGQYPKKYGSGHKY
What are the official names of this protein?
Immunogenic miracidial antigen 8C.
What is the protein family that this protein belongs to?
Belongs to the immunogenic miracidial antigen family.
Protein: TM219_HUMAN
Sequence: MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL
What is the function of this protein?
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
What are the official names of this protein?
Insulin-like growth factor-binding protein 3 receptor, IGFBP-3R, Transmembrane protein 219.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MBF1_CANGA
Sequence: MSDWESHTVIGQKARAGGSGPRANVARTQGQINAARRQGLVLSVDKKYGTANTKGDAEGQRLTKVDRETDIVKPKKLDANVGKTIARVRTEKKMSQKDLATKINEKPTVINDYEAGRAIPNQQVLGKMERALGVKLRGKAIGEPLGGPKKK
What is the function of this protein?
Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.
What are the official names of this protein?
Multiprotein-bridging factor 1.
What is the protein family that this protein belongs to?
Belongs to the MBF1 family.
Protein: RECU_BACC3
Sequence: MTIRYPNGKRYNQASQPHKTPIKKHTYSNRGMSLEEELNETNEYYLTHNIACVHKKPTPLQIVKVDYPARSAAVVKEAYFKQPSTTDYNGVYKGKYIDFEAKETKNKTSFPLQNFHLHQIEHMKQVIAHNGIAFVIIKFTLFDELYLLDAKHIIAFWNRQNTGGRKSITKEEIVEHGSLLSCGYHPRIDYIRVLDTVYFS
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_ECO81
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_LIMF3
Sequence: MAVPARKTSKTRKRNRRGHIKLTVPGLAPCPQCGELRKSHMVCPSCGYYDGKQVVENN
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PAX_I93A0
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKNLKSQELCAGLPTKVSRRTSPALRILEPMWMDSNRTAALRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: RS11_KARMG
Sequence: MEKTFTFRKKNSRNYNIGEAHIKSTYNNIIITLTNKKGDVIAWSSAGKMGFKGSKKNTPYAAQITAEDVAEKGLNAGIKKLKVIVKGPGAGRDAAIRALVNKNLILLVIKDITPIPHNGCRPPKKRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: P8_RDVF
Sequence: MSRQMWLDTSALLEAISEYVVRCNGDTFSGLTTGDFNALSNMFTQLSVSSAGYVSDPRVPLQTMSNMFVSFITSTDRCGYMLGKTWFNSDTKPTVSDDFITAYIKPRLQVPMSDTVRQLNNLSLQPSAKPKLYERQNAIMKGLDIPYSEPIEPCKLFRSVAGQTGNIPLMGILLTPPVAQQQPFFVAERRRILFGIRSNAAIPAGAYQFVVPAWASVLSVTGAYVYFTNSFFGTTIAGVTATATAADAATTFTVPTDANNLPVQTDSRLSFSLGGGNINLELGVAKTGFCVAIEGEFTILANRSQAYYTLNSITQTPTSIDDFDVSDFLTTFLSQLRACGQYEIFSDAMDQLTNNLITNYMDPPAIPAGLAFTSPWFRFSERARTILALQNVDLNIRKLMVRHLWVITSLIAVFGRYYRPN
What is the function of this protein?
Capsid protein which self-assembles to form the outer icosahedral capsid with a T=13 symmetry, about 70 nm in diameter and consisting of 780 molecules capsid proteins.
What are the official names of this protein?
Outer capsid protein P8, Structural protein P8.
What is the protein family that this protein belongs to?
Belongs to the phytoreovirus outer capsid protein P8 family.
What are the subcellular locations of this protein?
[Outer capsid protein P8]: Virion. Host cytoplasm. Note=Found in the peripheral regions of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RNPA_PORGI
Sequence: MTSPPTFGLSKSERLYLRDEINTVFGEGKAFVVYPLRVVYRLGSEHRVAYSSMLVSVAKKRFRRAVKRNRVKRLVREAYRLNKHLLNDVLQERQIYATIAFMVVSDELPDFRTVERAMQKSLIRIAGNVPSSALKNE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: ADCS_STRPR
Sequence: MRTVRTLLIDNYDSFTYNLFQMLAEVNGAAPLVVRNDDTRTWQALAPGDFDNVVVSPGPGHPATDTDLGLSRRVITEWDLPLLGVCLGHQALCLLAGAAVVHAPEPFHGRTSDIRHDGQGLFANIPSPLTVVRYHSLTVRQLPADLRATAHTADGQLMAVAHRHLPRFGVQFHPESISSEHGHRMLANFRDLSLRAAGHRPPHTERIPAPAPAPAPAPAPAPPASAPVGEYRLHVREVACVPDADAAFTALFADAPARFWLDSSRVEPGLARFTFLGAPAGPLGEQITYDVADRAVRVKDGSGGETRRPGTLFDHLEHELAARALPATGLPFEFNLGYVGYLGYETKADSGGEDAHRGELPDGAFMFADRMLALDHEQGRAWLLALSSTRRPATAPAAERWLTDAARTLATTAPRPPFTLLPDDQLPALDVHYRHSLPRYRELVEECRRLITDGETYEVCLTNMLRVPGRIDPLTAYRALRTVSPAPYAAYLQFPGATVLSSSPERFLRIGADGWAESKPIKGTRPRGAGPAQDAAVKASLAAAEKDRSENLMIVDLVRNDLGQVCDIGSVHVPGLFEVETYATVHQLVSTVRGRLAADVSRPRAVRAAFPGGSMTGAPKVRTMQFIDRLEKGPRGVYSGALGYFALSGAADLSIVIRTIVATEEAATIGVGGAVVALSDPDDEVREMLLKAQTTLAALRQAHAGATASDRELLAGSLR
What is the function of this protein?
Involved in pristinamycin I biosynthesis (PubMed:9044253).  Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine (By similarity).
What are the official names of this protein?
Aminodeoxychorismate synthase, ADC synthase, 4-amino-4-deoxychorismate synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the anthranilate synthase component I family.
Protein: UVRB_HELPY
Sequence: MPLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPALIMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSVMLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARGERVLITTLTKKMAEELCKYYAEWGLKARYMHSEIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKITQSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELKLRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECTKNLDFEEAMRLRDEIAQLRTL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSGA_SALHS
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMFSHSLALFSAAMFVLGLVSGITMSIGTFLITQLYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYACIGLVYLAIFILTFGCEFPALGKHAQHSQAPVVKEKWGIGVLFLAVAALCYILGQLGFISWVPEYAKGLGMSLNDAGALVSDFWMSYMFGMWAFSFILRFFDLQRILTVLAGMAAVLMYLFITGTQAHMPWFILTLGFFSSAIYTSIITLGSQQTKVASPKLVNFILTCGTIGTMLTFVVTGPIVAHSGPQAALLTANGLYAVVFVMCFALGFVSRHRQHSAPATH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOAA_ACAM1
Sequence: MNAVDYLRISLIDRCNFRCQYCMPDTQDLQFLQPTAVLTATELLTLIRDVFIPLGFARFRLTGGEPLLRPDILDIVRGVIALPQVKDLAMTTNAFLLEPLAQDLFEAGLRRINISLDSLVPETFATIVGRDSQRHKRWNKVWAGIQKAYQVGFNPLKLNVVIIPGVNDHEVLDLAALTIDRQWHVRFIEFMPIGNADLFCDRGWIPSEELRTQIRDRWGLTDGQVQGNGPADVFQIPGAQGTLGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTALRDGVSTDELRDRVRQLLELKPEINYKERQSGTVGANYSRTMSQIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: CLPS_ENT38
Sequence: MSKKNDWLDFDQLAEDKVRDALKPPSMYKVMLMNDDYTPMEFVIDVLQKFFSYDVERATQLMLTVHYRGKAICGIFTAEVAETKVAMVNEYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: AFP_PENCH
Sequence: MQITSIAIVFFAAMGAVANPIARESDDLDARDVQLSKFGGECSLKHNTCTYLKGGKNHVVNCGSAANKKCKSDRHHCEYDEHHKRVDCQTPV
What is the function of this protein?
Antifungal protein that acts as an inhibitor of growth of human pathogenic molds and yeasts (PubMed:19683356, PubMed:29379111).  Is active against the model organism Neurospora crassa, the opportunistic human pathogens Aspergillus fumigatus, Trichophyton rubrum, and Aspergillus terreus (PubMed:29379111).  Provokes a reduction of the incidence of infections caused by Penicillium digitatum and Penicillium italicum in oranges and by Penicillium expansum in apples (PubMed:34199956).  Low doses of pafB have self-inhibition activity (PubMed:29379111).  Shows also activity against the model yeast Saccaromyces cerevisiae and the opportunistic human pathogen Candida albicans (PubMed:35499318, PubMed:29379111).  No antibacterial activity is observed on the Gram-negative Escherichia coli and the Gram-positive Bacillus subtilis (PubMed:29379111).  Finally, shows also anti-viral activity in a model of HCoV 229E infected L132 cells (PubMed:29379111).
What are the official names of this protein?
Antifungal protein B.
What is the protein family that this protein belongs to?
Belongs to the antifungal protein pafB family.
What are the subcellular locations of this protein?
Secreted.
Protein: SET1_DEBHA
Sequence: MSYNPYRSRNYGGGYSNNGYRQRHYYSDYNESSYNSSYRDQYDRNGSYSGSKGRHYNSGTSRNAPPPSSSAYSSDSSSRTYANSSSSGPAKIPVGPKSLTIDGSTNGDLPTAGTQKHNIPPTNAISGTDATTGVNPNDSNFTQLLLHQDLSKQIEFSGEIDSKRNYKVIYDPELDKSLSKAERKTKQKKIRFNGESLSSHDVTDPRKSSTGSTSAYFLKPNKKSKKFPFKQLPQPKFIYDKDSLGPPPQNEIVVWDLPSTTSEVYLSNFFKSYGDSIKDLKFINDPLNAVPLGIATCKFQGNPDKSMRIAKKFIANVRINHTKIDGAELKIALNDNDNKLLDDKIKVAQDKLRISRIKIEEEEKKRLKKQQAIEDQKRRETEKAAKEKKLQESANSSHESRFKPNTTTLSIRHHNEVIPGVFLPRELRKYIRDRPYIFINDKYVPTRKVSSQDIKKVLNKYDWTRVLPDRSGFFVVFNSIKECERCFINEDGRKFFEYKMFMELALPENFNESSSSTSNNDNTDLSASNRKQNDVVEEASNMLIKEFQNFLAKDIRERVIAPVVLDLLSHDKYPKLVEELKAKELATKKAASPIVTNAVRQVKSKPNVLSSLAIKSKPQAILPSFRKKKDLPNAGLNSANKAKKNVIPMQHALNYDHESDESDEDDSTRSTTPLTPTLKRERSPTVSSVSNDNDIEDKLEDIQKPSKKKQKKTKLHQSFLYDSASDEDMEAVSEEKEVEKDESEGEEDIDYSHIDKIYQPTEDYPRPVYEEVPRFPSDPLDLDALQSIIKDDEDITLLQTALADVTSESNIKNMEYWAWKQKDIKAKAGVQEISEDLEVIGPLDSRFDSKSGAFKSEGYRKIPDADKIEYLPHRRKIHKPIKTIQHDDDELNANNSTTNNNSNNIQSSRVNRANNRRFAADISAQKQMLGSETDILNLNALTKRKKPVSFARSAIHNWGLYALEPIAAKEMIIEYVGESIRQQVAEHRERSYLKTGIGSSYLFRIDENTVVDATKKGGIARFINHCCNPSCTAKIIKVEGKKRIVIYALRDIEANEELTYDYKFEKETNDAERIRCLCGAPGCKGYLN
What is the function of this protein?
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-4 specific, COMPASS component SET1, SET domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TMCA_NITHN
Sequence: MHPILFPPTLDNIRKITASLVAAAKASGHRRALVLSGDREWCLQAAQVSLASTSLEPVLWIAAQAPENAWRMEAAKAHRSLGQEVDAIVFDAYSGFDLDAFGIITGAIRGGGLLLLLTPPLAAWPSFNDPEHARIVTAPYEVTEVTGRFLKRLVRILREAEGVIIIEQGKILPSVPFAAPARAETGGNPPSPGDSACRTEDQGRAVEAIVKVVTGQRRRPVVLTSDRGRGKSAALGIAAARLLQRGLKHIIVTGPRLDAVEPVFRHAQRLLPQATVSRAALHLPEAGMEFAPPDDLIRTSRPADLLLVDEAATIPTPLLERLLQGYSRIAFATTIHGYEGTGRGFALRFHRVLDEKTRGWKGLRLETPIRWRSGDPLEHFVFRALLLDATAAPDSAVASARPETVAVERLDRDALVRDEATLSELFGLLVLAHYQTRPYDLRHLLDGPNLSVYVMRYRGHVVATALLAAEGGFVEETARGIWEGRTRPHGHLLPESLAAHLGLAQAPRLHCARIMRIAVHPAVQGQGLGTHLVDTIIRETGGEGLDYLGSSFGATVELLRFWERLDFLPVRLSVKRGATSGAHSAIVLHPLSSSGQALVKRARERFLVHLPHQLADPLRELEPQLAAWLLRRGDPAGPLPLDSQDWSDVLAFAFGRRVYEVCIGPIWKLTWGALAAPESATLLGEVERNALIVKVLQKRSWQEAAAALELSGRAQVIEVLRRTLRPLVLHFGNEAVRREAERLAGG
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
What are the official names of this protein?
tRNA(Met) cytidine acetyltransferase TmcA.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_CHLAB
Sequence: MTDSSNAHEAENPTVPTPDNEIQDLQQEIATLKAELKEKNDKYLMVLAESENARKRMQKERQEMMQYAVENALIDFLVPIESMEKALGFASQMSDEVKNWALGFNMILQQFKQVFEEKGIVEYSSVGQKFNPFLHEAVETEETTKVPEGTIVEEFSKGYKIGDRPIRVAKVKVSKAPAPQGTEAEIENNNE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGK3_SCHPO
Sequence: MSLAWKNELLKLLKENVDSSGVIHPEYFQLATLPTGNEIYPRNRTVAIRGFVGTGWHKPRPDDVLATDLLVFSTDIASHKAAEIAEQQKNTFPSGPIPNAFEMCGWLPKTMQQIRISGQIWLYTPELADRNEFPADKLIQDHLINSNGRIPEEWSWEEERRRIWELHSPELRASFSTPPSYSKYQGDVKVSPLPSTLTGKEDPGVIEAWKTAWGRFSLVVCEANEVEFLNLTPPPGKRVLHNRDLNTKQWSSTRVNV
What are the official names of this protein?
Uncharacterized protein C725.03.
What is the protein family that this protein belongs to?
To yeast YGR017w.