PharMolix/UniProtQA huggingface dataset:
Protein: ATPB_JASNU
Sequence: MRMNPTTSGSGVSTLEKKNLGRIVQIIGPVLDVSFPSGKMPNIYNALVVQGRDTVGQAINVTCEVQQLLGNNRVRAVAMSATDGLMRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDELGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEENIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGTLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYKIAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLEMESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TOR2X_MOUSE
Sequence: MAVARHGYRPWGSILGLLGLALAAAAAWDVASLRCTFGSFCECDFWPDLPGLECDLAQHLAGQHLAKALVVKSLKAFVQDPAPSKPLVLSLHGWTGTGKSYVSSLLAQHLFRDGLRSPHVHHFSPIIHFPHPSRTEQYKKELKSWVQGNLTACGRSLFLFDEMDKLPPGLMEVLQPFLGPSWVVYGTNYRKAIFIFIRWLLAVWHHGGAPAGRCGALPPAPAASRAPLRTQ
What is the function of this protein?
Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis.  Salusin may also be a potent hypotensive peptide (By similarity).
What are the official names of this protein?
Prosalusin, Torsin family 2 member A, Torsin-2A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPH_OENBI
Sequence: MNPLISAASVIAAGLAVGLASIGPGIGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AHPF_PSEPK
Sequence: MLDATLKSQLKTYLERVTQPIEIVASLDDGAKSRELHDLLVEIASLSNLITFSADGTDARRPSFSLNRPGADISLRFAGIPMGHEFTSLVLALLQVGGHPSKASAEVIEQIQALEGEFNFETYFSLSCQNCPDVVQALNLMAVLNPNVRHVAIDGALFQDEVESRKIMAVPSIYLNGEVFGQGRMGLEEILGKIDTNAGARQAEKINAKEAFDVLVVGGGPAGAAAAIYAARKGIRTGVAAERFGGQVLDTLAIENFISVQETEGPKLATALEEHVKQYDVDIMNLQRGEALIPAAEGGLHEVRLAGGASLKAKTVILATGARWREMNVPGEQEYRGRGVAYCPHCDGPLFKGKRVAVIGGGNSGVEAAIDLAGIVAQVTLIEFDSQLRADAVLQRKLRSLPNVNVITSALTTEVLGNGEKVTGLRYKDRSTDEQHEVALEGIFVQIGLLPNTDWLKGTVELSPRGEIIVDAKGQTSIPGVFAAGDVTTVPYKQIVIAVGEGAKASLAAFDHLIRTSAPA
What is the function of this protein?
Serves to protect the cell against DNA damage by alkyl hydroperoxides.  It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity).
What are the official names of this protein?
Alkyl hydroperoxide reductase subunit F.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: SPC42_YEAS2
Sequence: MNGSPTPKRYSSKSSRLYDDYYNIPYQYSNPTPMNRDYNDVGSRINADKLVPEEYKRNTEFINKAVQQNKELNFKLREKQNEIFELKKIAETLRSKLEKYVDITKKLEDQNLNLQIKISDLEKKLSDANSTFKEMRFPKVKDPMVDDDPVSENYDQINVPKHRAPDATGNPRTTNKVSNTSDQDSRLKAIERTLSVLTNYVMRSEDGNNDRMSPLPSPLNTISPINNRLNFQEPKRYNPTVKVNPSDDDIMMYESAELKRVEEEIEELKRKILVRKKHDLRKLSLNNQLQELQSMMDGDDNIKLDNVSKHNHATHRHSSQSSRDYSPSSDACLECSNDLYEKNRVKPENNMSETFATPTPNNR
What is the function of this protein?
Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
What are the official names of this protein?
Spindle pole body component SPC42.
What is the protein family that this protein belongs to?
Belongs to the SPC42 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: PSBH_THAPS
Sequence: MALRTRLGEILRPLNAEYGKVVPGWGTTPIMGLTMVLFLVFLLIILQIYNSSLIIENVDVDWANAI
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y234_BUCBP
Sequence: MITITIVYFTNKIQHVKKIKLNIGTPVHEALKILQINIKKNNKIGIYGELVSLNHILNNKDRLEIYRPLKINPRELRKQKINRKLK
What are the official names of this protein?
UPF0125 protein bbp_234.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: PYRG_PYRFU
Sequence: MTKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFLDTELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITDEIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQLEEGRDNVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDVEDTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKLQDSYLSIKEALKHASVSNEVKVKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGKIQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHSTEIDPQTPYPVVDLMPEQRNLDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGVAGDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: US06_HCMVT
Sequence: MDLLIRLGFLLMCALPTPGERSSRDPKTLLSLSPRQQACVPRTKSHRPVCYNDTGDCTDADDSWKQLGEDFAHQCLQAAKKRPKTHKSRPNDRNLEGRLTCQRVRRLLPCDLDIHPSHRLLTLMNNCVCDGAVWNAFRLIERHGFFAVTLYLCCGITLLVVILALLCSITYESTGRGIRRCGS
What is the function of this protein?
Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP).  Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2.  Also prevents the conformational rearrangement of TAP induced by peptide binding.  In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).
What are the official names of this protein?
Unique short US6 glycoprotein, HXLF6, gpUS6.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US6 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y630_VEREI
Sequence: MKFLEFLGKRPPAAAPGPAPAPASAATASERGHAAEDLALAHLQAAGLQLVARNYRTPGRGGGEIDLVLRERDRTLVFVEVRNRSHGAFGGAGGSIGATKQRRIIFAAQHYLRRLPAPPPCRFDVVLVQEQEPVQWIKAAFEAQ
What are the official names of this protein?
UPF0102 protein Veis_0630.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: TPIS_YERPP
Sequence: MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIALGAQNVDVNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIGLIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFEGAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKADAFAVIVKAAAKAKKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HENMT_MACFA
Sequence: MEENNLQCSSVVDGNFEEVPRETAIQFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLVGVDINEDKLRWRGDSLAPFMGDFLKPRDLNLTIILYHGSVVERDSRLLGFDLITCIELIEHLDSGDLARFPEVVFGYLSPSMIVISTPNSEFNPLFPSVTLRDSDHKFEWTRMEFQTWALYVANRYDYSVEFTGVGEPPAGAENVGYCTQIGIFQKNGGRATEACVSEQHDQHVYKAVFTTSYPSLQQERFFKLVLVNEVSQQVESLRVSHLPRRKEQDGEQGDKPKDIGGSKAPVPCFGPVFTEVEKAKIENSPKPFCVGDKFFVPLQRLLAYPRLNRLCANEEMMRSVIADSIPLSSDGSAVVTDLCNYFDEQFEF
What is the function of this protein?
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.  This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation.  Stabilization of piRNAs is essential for gametogenesis.
What are the official names of this protein?
Small RNA 2'-O-methyltransferase, HEN1 methyltransferase homolog 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. HEN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis.
Protein: YR424_MIMIV
Sequence: MKNDYQIVTYNKTNYYVFRYVKTQESEKLFVIDEDDFDIIMSTGLSFYGIHSYIGHNITINDEQYTAYLHDYIVRDGDISSLVHHINHNTHDNRKVNLISVPKDEFELYQPKYHRTIELPKKCGINENQIPKFVHYVSKTKKHSDKFVFKMNIIGKDKPLIYQSSESKDISTFDKYVQIVEIILKLNNQYPEYFINKGIIENYSDNSLQLMKEYNEIISLTSYDCVKKNIMDIPKKFKLESLMSKASIKVQQYLETVDLTKKTGKNIKSNLPKGCGVTLDMIPKHCYYRPANEKTGDSFRIDRKHPLIVNGKELSTTSKKKVSTKDKFDELIKLLETLDNKH
What are the official names of this protein?
Uncharacterized protein R424.
Protein: DAPB_BDEBA
Sequence: MKKIKIGLMGSAGRMGQEIAGVIEANPRCELVYAPLRGEKWDSKKAQAVDVWIDFTSPEALKDILKKASETKTPVVCGTTGFSKKEKELLKTYSKKIPVLWSSNMSLGVAVLNEALKAFSAISHFDFQIEEIHHNRKKDRPSGTAITLQENLEKAVDKKLPEALAIRGGGVFGVHKIFAMSDEEVLTFEHTALNRTVFAKGSVQAAEWLVKQKPGLYQIRDVLFGKSKK
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3584_COLP3
Sequence: MKIWVDADACPVVIKEILFKAADRTKIAITLVANHHVRIPPSPFISFMQVSSGFDVADDEIVKRIEANDLVITSDIPLADEVIDKSGIALSPRGELYTKENIKSRLNIRDFMDTMRASGVHTGGPPALNQTDRQNFANHLDRIITQFKKTQ
What are the official names of this protein?
UPF0178 protein CPS_3584.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: LAMB_SALNS
Sequence: MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQVTGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVNQQNDWESTDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGIENIDLGFGKLSLAATRSTEAGGSYTFSSQNIYDEVKDTANDVFDVRLAGLQTNPDGVLELGVDYGRANTTDGYKLADGASKDGWMFTAEHTQSMLKGYNKFVVQYATDAMTTQGKGQARGSDGSSSFTEELPDGTKINYANKVINNNGDMWRILDHGAISLGDKWDLMYVGMYQNIDWDNNLGTEWWTVGVRPMYKWTPIMSTLLEVGYDNVKSQQTGDRNNQYKITLAQQWQAGDSIWSRPAIRIFATYAKWDEKWGYIKDGDNISRYAAATNSGISTNSRGDSDEWTFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: RNBR_BACAM
Sequence: MMKMEGIALKKRLSWISVCLLVLVSAAGMLFSTAAKTETSSHKAHTEAQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR
What is the function of this protein?
Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates.
What are the official names of this protein?
Ribonuclease, Barnase, RNase Ba.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease N1/T1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU3_STAAN
Sequence: MTYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKEERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAASRRGKLTSVDKENVLASSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKLNH
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPRS_YERPE
Sequence: MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQNLENPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAVDNIRNSVIDEVIVCDTIPLSAEIKALKNVRTLTLSGMLAEAIRRISNEESISAMFEH
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAL_CYAM1
Sequence: MTDYIKPYNNDPFVGHLATPINSSSLTRAYLSQLPIYRRGVSPFLRGLEIGMAHGYFLIGPFVQLGPLRNTDIKYLAGLLSAIGLIVILTLGMLLYGAVSFTNDSQDLESVDGWRQLASGFLLGAVGGAGFAYLLLTLFS
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LOLA_SHEHH
Sequence: MKKIFAIAALSLPLFSHFPAFAGASDELKVKLTEISSLKANFNQTVTDINDKVIQTGEGVFALSHPNQFYWHLTAPDESLIVADGTDVWIYNPFAEEVSVMDLNQAINASPIALLVHSDDETWSQYNVSQKENCFDISPKDKDSGGSEVQVCFNDNQLTKMVLKDQQGNISDFTLTNQSVIAGKDQDLFKFVVPDDVDIDDQRLKSTN
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y1188_AQUAE
Sequence: MTFLFLILVFIIEILQLSVFPPIFGNAYIVPSLAFLLVLFSSYKIKEKALLLAFLSGLFYDAVVNFLGFISLLNVVFTYLYLVLNNILFVKNPKVEVFLIMPLILLLRKLTIFLVVNTKFPLNIGLKDFGVVLLIDLIFLILLYKVFNKYVYEKA
What are the official names of this protein?
Uncharacterized protein aq_1188.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OBG_SYNC1
Sequence: MKFIDRVKIHVKAGDGGRGCLSFRREKFIPKGGPDGGDGGRGGNIVLRVDEGLGTLLDLRYQIHYKAQRGAHGMGKNCHGKNGEDLEIRVPPGVLVYDAETDELLADLTEGCHELVVVRGGMGGRGNARFATSTNRAPRHVQPGVEGEERWLRLELKLLADVGLLGMPNAGKSTLISAVSAARPKIADYPFTTLVPNLGVVRCGGFKTFVMADIPGLIEGASEGHGLGTRFLRHVERTDLFLHLVDLSDLQEGDPMERFALINRELARHNPELMEKPQLVVLSKIDVSEVRERLDAVRAAFAAEGIRTLAISAVTGEGLKELVAEVARELEKLRASRLQADQKAAEEDEPWQPDLS
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_RHILW
Sequence: MSQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFNDPVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLAGFAVGAAERGKLLPSGDIAEGDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLKAIRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEMLRTFNCGVGMIAVVASENVAAVSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBG1L_MOUSE
Sequence: MEVRASFQKVSGSSDSVATLNSEEFVLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRSEVEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL
What is the function of this protein?
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity).  Plays a role in endocytosis and intracellular protein transport.  Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells.  Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357).
What are the official names of this protein?
Rab GTPase-activating protein 1-like.
What are the subcellular locations of this protein?
Early endosome. Golgi apparatus. Note=Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (PubMed:27718357).
Protein: KAD_DESVM
Sequence: MNILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFRQHIGGGTELGKKAKEYIDRGDLVPDDITIPMVLETLKGAGPNGWLLDGFPRNMVQAQKLWDALQAEGLKLDYVIEILLPREVAKNRIMGRRLCKNDNNHPNNIFIDAIKPDGDVCRVCGGSLSARADDQDEGAIGKRHDIYYNTEDGTLAAAYFYKDLAAKGVTKYIELDGEGSIDSIKDTLLKQLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG4_PHANO
Sequence: MNDFERFGRNVVRTFYDPPPCNESNEPIWLLGQRYDSRPPLPKPAPSDSSTTATATAQAERNEDESWIRTSIDDKERKEAPNGEDPTQYGNWPSAFLDDFESRVWMTYRSGFSPIQKSQDPKATSAMSFRVRMQNLASPGFTSDAGFGCMIRSGQCILANALQILRLGRDWRWQENHADKDHAEILSLFADDPQAPFSIHRFVEHGAAVCGKYPGEWFGPSAAARCIQDLANKHREAGLKVYVSGDGADVYEDKLKQVAVDEDGLWQPTLILVGTRLGIDKITPVYWEALKASLQIPQSIGIAGGRPSASHYFVGVQGNNFYYLDPHSTRPLLPFHPPSLAAATSDTPNLTASTTSVSSTTSSTTIVPPADSIPAPSDPRQSLYPPSDLSTCHTRRIRRLQIREMDPSMLLAFLVTSEADYQDWKEGVQGVQGKSVVHVQDKEPPPRGQEREGAIDEVESWDEDGLQ
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.