PharMolix/UniProtQA huggingface dataset:
Protein: FABD_STAAN
Sequence: MSKTAIIFPGQGAQKVGMAQDLFNNNDQATEILTSAAKTLDFDILETMFTDEEGKLGETENTQPALLTHSSALLAALKNLNPDFTMGHSLGEYSSLVAADVLSFEDAVKIVRKRGQLMAQAFPTGVGSMAAVLGLDFDKVDEICKSLSSDDKIIEPANINCPGQIVVSGHKALIDELVEKGKSLGAKRVMPLAVSGPFHSSLMKVIEEDFSSYINQFEWRDAKFPVVQNVNAQGETDKEVIKSNMVKQLYSPVQFINSTEWLIDQGVDHFIEIGPGKVLSGLIKKINRDVKLTSIQTLEDVKGWNEND
What are the official names of this protein?
Malonyl CoA-acyl carrier protein transacylase, MCT.
What is the protein family that this protein belongs to?
Belongs to the FabD family.
Protein: BIOAB_BACFR
Sequence: MTIEEIKNQVLQGTAISREQAGWLALYPRKEELYDAAHDITTACASQEFDMCSIINARSGRCPENCKWCAQSSHYKTKADVYDLVSAEECLRQAKYNEAQGVNRFSLVTSGRKPSPKNMKELCVAVRRMRRHSSIRLCASLGLLDEEELQALYDAGVTRYHCNLETAPSHFDSLCTTHTQEQKLKTLYAARRVGMDLCCGGIIGMGETVEQRIEFAFTLRDLNIQSIPINLLQPIPGTPLEHQSPLSEEEILTTVALFRFINPAAYLRFAGGRSQLTPEAVRKSLYIGINSAIVGDLLTTLGSKVSDDKEMILSEGYHFADSQFDREHLWHPYTSTSNPLPVYKVKRADGATITLESGQTLIEGMSSWWCAVHGYNHPILNQAVQDQLSRMSHVMFGGLTHDPAIELGKLLLPLVPPSMQKIFYADSGSVAVEVALKMAVQYWYAAGKPEKNNFVTIRNGYHGDTWNAMSVCDPVTGMHSIFGSALPIRHFLPAPSSRFGDEWNPEDIRPLEHLLEKHADELAAFILEPIVQGAGGMRFYHPEYLREAARLCHRYGVLLIFDEIATGFGRTGKLFAWEHAGVEPDIMCIGKALTGGYMTLSAVLTTNEVADCISNHAPGAFMHGPTFMGNPLACAVACASVRLLLTSGWQENVKRIEAQLNRELAPARELPQVADVRVLGAIGVIEMKEPVNMAYLQRRFVEEGIWLRPFGKLIYVMPPFIITPEQLTKLTEGMIRIISNGLPGSQTK
What is the function of this protein?
Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA).
What are the official names of this protein?
Biotin biosynthesis bifunctional protein BioAB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
Protein: YHAQ_BACSU
Sequence: MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTFRMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGMEKREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGLDPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKRSFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIRKFELEEPSLHDIFIEKVGAVYE
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YhaQ.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PURT_SHESA
Sequence: MIGTPYTEGARRAMLLGCGELGKEVAIELQRLGVEVIGVDRYPNAPAMQIAHRSHVINMLDAKALRAIIELEKPHLVIPEIEAIATQTLVEMETEGLNVVPTARATQLTMDREGIRRLAAETLGLPTSPYFFCDTETEFNQAIGKIGVPCVVKPVMSSSGKGQSVIRDAAQSTKAWQYAQEGGRAGGGRVIVEGFIPFDYEITLLTISAVNGIHFCAPIGHRQEDGDYRESWQPQAMSADVLAKSQAIASKVVEALGGYGLFGVELFVKGSDVYFSEVSPRPHDTGLVTLISQDLSEFALHVRAILGLPIPNIHQHGPSASAVVLVEGKSKNIRYQGLADALAAENTQLRLFAKPEIDGRRRLGVALARDKDIESAVNKALDSASKVKVIF
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: HLH4_CAEEL
Sequence: MPMVVAKRNARERTRVHTVNQAFLVLKQHLPSLRQFTKRVSKLRILNAAITYIDTLLKLIQSSEAVPQSVISATLGPIVPTPVRAVHKISKPDTVISQPIRPLAPVLPRHETYLPAPIAATCAPDHSLVDYRSTFASSLAPPVPMQMPSVFSPQPTFPYMKSLLDYPTYFYQPSTAPPPPPAPTAPQSHLIVNNQLVPMPSYQCF
What is the function of this protein?
Acts as a transcriptional regulator (PubMed:27487365, PubMed:29672507).  May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3' (PubMed:29672507).  Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4 (PubMed:29672507).  Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions (PubMed:27487365).  Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons (PubMed:29672507).
What are the official names of this protein?
Helix-loop-helix protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y418_STAA3
Sequence: MKSIKRIGLCISLLILIIFVTSCDGDNKIIGDSKEEQIKKSFAKTLDIYPIKNLEDLYDKEGYRDGEFKKDDKGTWLIRSEMKIQLKGENLESRGAVLEINRNTRTAKGHYIVREVVEDSDGMTHNHTKRYPVKMENNKMIPLKPIDDEKVKKEIEEFNFFVQYGNFKELENYKEDEVSYNPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFIENKEENIYFTDSIYFNPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAUSA300_0418.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LPXH_LARHH
Sequence: MATLILADLHLSADTPAFNDAFLRLLNAAAGQIDALYLLGDIFEVWLGDDDPAPFPRSIISALHRFATSTPVYVMHGNRDFLLGPRFARESGATLLADPTLVELHGHRYLLSHGDLLCTDDIAYQRFRRTIRQPWRQWLLRHLPLALRQRIGQRLRQQSRTAKNDKPLYIMDASTEEVGRWLLEHAGSTLIHGHTHRPGHHRHVLTNGTLAERWVLPDWRPGQTGGLWIDQNGVHPAPDPLYDLQTHTGNQTR
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VPS36_DICDI
Sequence: METLFQKTRVINGEPELIQNESIIYKVDNVSIYDGDQKTQYSNGTVMLSTHRVIWVNKDIGLGLLHQLILNIEALTTGLMGIGSSPKILITLTKRSFRLSFHAGRRDDFLKLYRQSLLNKPSQSPSPTSSTSQFINQPNNNNNNYNNNNSYQTPLQPPQYQQQQKEQQQQYNSYNPYQQQSSQSPQQPQQQYNSYNPYQSYVQQQQQQQQQQQQQQQQQQIPQYQQQTSPPPPNYYEHIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQRQQSPSLYNSYHSTQQPLPPPSYLQHMQQQQQQSPSPSPQYQQTNSNSLPSQPPQPNYNLQNFINTPIISNNSNNNNTNINGFTSNAGIGGIINQMNKKTLENDKLLSESFSDLNILMEKAKDMVTLSEKLKVTLEKKTGTSTSTEEEEEFRSFLLEMGIESPVTKKTAKSKYHDQLSKQLSDWIITKNILKQHKGSGNNEMITLSDLYCIFNRARGIELISPDDLYRACLLFESLDLPLRLRKFDSGVIVVQSKDENDEQIAKQILDIINENGPLSAFDLAKINSISLHLAKDQLLVGVTSEKLGKLCRDETVEGNILYHINIFVD
What is the function of this protein?
Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
What are the official names of this protein?
Vacuolar protein-sorting-associated protein 36, ESCRT-II complex subunit VPS36.
What is the protein family that this protein belongs to?
Belongs to the VPS36 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Protein: MURD_FERNB
Sequence: MQYALLGLGLSNKYAAKFLLKLGEKIFVSESGKLSSEDKAFLEENNIPYEEGVNSEKILEADVILTSPSVPHNHPILLKAQQMGKYVDTEITYFMKFLDWKPKIIAVTGSVGKSTTVAMINHLISKSASSQISGNFGIPIAQVLLEGKKPEYIVVEISSFQLYWTPFFKPNVAVITNIYPNHLDWHPSMEHYVDSKFKITKFQDNEDHFVYNPKDMETFKRLALVQAKRVPFTVDFKFEEIPFHIRTKQNMENIAAAKTVLKVLGLPFSMSMLEDFTPLPHRMEYCGTINGAHYYNDSKATNAAAVVKALENFDNNLYLIIAGKGKNEDYSKLANEISKKCKFVAIVGPISDAVEPYLKERNVNYKRFSNIEEAVFEISKMAKEGDYVLLGPAGASYDAYKNFEERGNHFKEIVKKLMQG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_EROBO
Sequence: MTNIRKTHPLLKIVNSSFVDLPAPSSLSSWWNFGSLLGVCLAVQILTGLFLAMHYTSDTATAFNSVAHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYLFTETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSTLVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAVVPLLHTSKQRSMMFRPLSQCLFWLLVAVLLTLTWIGGQPVEHPYVIIGQVASVLYFLILLIFMPLISILENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EXOC7_DROME
Sequence: MNNLDSSLQAHNKLEKEATNLALLKDRVDKYHDLSTQMSSILTIFEKRLGNLEQTILPVYQETEQLQKRQQNLEATLNCLESVLSHYDVSQEVCQLIHQGPVEGNISVFLDALAKLRDANDYFRHNNSQSVELENVTSLFNTGCEGLSQHYSMLLKKHSAPLKPVELLDLIYIEDDSSDEYTSFRQLSQTTREELYTISHWLEQNLREYTNIYATERGEVVLRSLQLLKDHQKSNSWGHEALRPRHSGRQTEPKKTTSARLQQIFEKKANKLYLRATQTIEQSTGFSIKKASSHSDHLTSEDLMDGDQELDKYLVMLLGLQRLLNWERAIMIDIIPQSKHNEVFATLAYNAIDLVVKDAEAITQRILRCISRKEWTSALGIFSALKRVILLQPDIDRTYDPAQREQLKKVLKKLQHTGAKALEHFLDVVKGESSTNIVGQSNVPKDATVHELTSNTIWFIEHLYDHFDVIGSILAQDVLYSTQLDTILMKKALPVEERNKALLAIYIKKALAELNLSIMNKCEQYNDQATKHLFRLNNIHYILKSLQRSNLIDLVTLAEPECEHSYMEMIRELKASYQKTWSKMLVGIYSLDELPKPVAGKVKDKDRSVLKERFSNFNKDFEEACKIQRGISIPDVILREGIKRDNVEHILPIYNRFYEIYSGVHFSKNPDKYVKYRQHEINAMLSKLFDDSA
What is the function of this protein?
Required for exocytosis.  Thought to function in intracellular vesicle targeting and docking before SNARE complex formation.
What are the official names of this protein?
Exocyst complex component 7, Exocyst complex component Exo70.
What is the protein family that this protein belongs to?
Belongs to the EXO70 family.
Protein: SYM_LEPBP
Sequence: MSKHILVTSALPYANGSIHLGHILEAVQTDIWVRFQKLIGNECYFFCADDTHGTPIMIAAKKAGKTPESMIEEVQKEHYKDLTSFGVEYDNYYTTNSEENKKFSESIYLTLKKNGHIVARNIEQSYCEHDKMFLPDRFIKGTCPKCGAKDQYGDSCEVCGTSYSPKDLKDSYCSICGTTPVLRESKHLFFKLQDFQNQLKNWMEEGNRLNEGAQKKLQEWFTSGLQEWDISRDGPYFGFAIPEEENKYFYVWLDAPIGYMASSLNHLKDERKFNEFWKEGKGEIVHFIGKDILYFHGLFWPAMLMGSGYKAPSQLNVHGFLTVNGEKMSKSRGTFINASTFAKYLDVEHFRFYLACRLGSGMEDVDISFDDFVSRVNSDLIGNLVNLVSRVSTSILDKMDRKLGILSTEGKSLVSELLSKETEIREAYVSRNYSKVMRDITGLGDKVNKYVNDYAPWNLIKTDVEKAREVVTTSLNCAKILFTYLAPVTPKIVHSLADLFQIPNLSFLNLTETIENKVLGPYQMLSKRVEEKNITIMITETKETFEKSNPEKAKQDPSKSNTNEVKSATVSEDGFITIDELSKVELRVGLIKEANPVEGADKLLFVKVDLGEKGIKNVFAGIKASYTAEELVGKKVVVVANLKPRQMKFGLSEAMLLASGKDKTLSLFVPDRDASPGDLLK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_BRUMB
Sequence: MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLQKTVRQSKKYKAHDENNQFKVGDFVSIQESAPISKDKRWVVLTSEAAG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: Y2684_STAAM
Sequence: MTEPIISFKDFSFQYHSQATPTLQNINVDIYPGEKVLVVGASGSGKSTFANCINGLIPFKTKGNITGELYINNQDATVSCLHDRSNVVGTVLQDTDGQFIGLTAAEDMAFLLENNCVEQDDMKKNVSYWAEKVGMIEHLNHRPQDLSGGQKQRVSLGGILIHRTPILILDEPLANLDPATGHETLRLLNNIHEETKSTMIIVEHRLEESLDDTFDRVLLFKDGKIIANTTPSDLLKSSKLKEAGIREPLYCTALKYAEVDVESIDNLANLRDVCMSEHVKFKVKKWIDETSANNDNKYKSEPLLELNEVCVQYSDYSNSVLNNVQLNVYRREMLSIVGHNGAGKSTLAKAICGFLDITGNIQFCNRGFNQLSISERSEFVGYVMQNPNHMISEKMIYDEVALGLRARGMKESDIKIRVENVLKICGLYAFRNWPIAALSYGQKKRVTIASVLVLNPEIIILDEPTAGQDFYHYNEIMSFLIELNRQGKTIIMITHDMHLLSEYSSRTVVLSKGQVVADTTPVLILNDKKICEIASLRQTSLFEMAEYIGISEPQKLVQLFINHDRKVRRQ
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein SAV2684.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RF2F_ORYSJ
Sequence: MSTLVTCSLPGAVTTHASTRRFGGSQFQTSQASCISFKREVSAKAVLRSVRCNATQTQSAQRKSSTATVKRSDPKGKIQGPKLDDGSGGFPPFRFGKGGGGGGGGGGGSNYFGGFLLFTCVLLLDYLKEFEKNLIARRQRAGYDANNDMFQQ
What is the function of this protein?
Restores fertility in rice varieties with LD-type cytoplasmic male sterility (CMS) (PubMed:21265890).  CMS is caused by genetic incompatibility between nuclei and mitochondria within male reproductive organs (PubMed:21265890).  Corresponds to the functional allele of RF2, which is dependent of the presence of Ile-78 in the japonica cultivars Fukuyama and Owarihatamochi (AC F1SZ42), and indica cultivar Kasalath (AC F1SZ41) (PubMed:21265890).  Non-functional RF2 alleles are found in japonica cultivars Taichung 65 and Nipponbare (AC F1SZ44), where Ile-78 is replaced by Thr-78 (PubMed:21265890).
What are the official names of this protein?
Protein FERTILITY RESTORER RF2, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MIAA_DEHM1
Sequence: MKRTDSTAKATAPNPPLAPLLVILGNTGSGKSALALKLAREIPAGIVNADSRQIYSQMDIATAKPTPAEMSEIPHYLYSFIQPDQPFSLAEYQSLAYQAINKLHTQNRLPILVGGSGQYLKAVLEGWSIPQIAPDETFRAAMFEKAEKEGGASIFAELVKQDPQAAAKIDPRNIRRVVRALEVINKTGAEFSKLQTKNPPPYRVLKIGIHLAREELYRTVDLRVGKMLEQGLEAEVRHLLEQGYAATLPSMSGIGYRQIAKYIGGEISLSEAIEQMQFETHRLIRQQNTYFRLADPDIHWITLEESMDSGIINLVRNFLADGGKE
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: BABA1_RAT
Sequence: MEVAEANSPTEEEEEEEEEEGEEPISEPRPHTRSNPEGAEDRAIGAQANVGSRSEGEGEAATADDGAASVPGAVPKPWQVPAPASEVQIRTPRVNCPEKVIICLDLSEEMSVPKLESFNGSRTNALNVSQKMVEMFVRTKHKIDKSHEFALVVVNDDSAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDIIYIHSGPEEKEDDMSWKDMFAFMGSLDTKGTSYKYAVALAGPALELHNCVAKLLAHPLQRPCQSHASYSLLEEDEEAGEGEATV
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
What are the official names of this protein?
BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex.
What is the protein family that this protein belongs to?
Belongs to the BABAM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: KHSE_PROM9
Sequence: MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESANMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCDWHDSIKAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKLIKGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFLNLQTTGSQFSTISSR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_BACCZ
Sequence: MKKVLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAEAMGVELECFQSNHEGAIIDRIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLREA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SBTXA_SOYBN
Sequence: ADPTFGFTPLGLSEKANLQIMKAYD
What is the function of this protein?
Involved in plant defense (PubMed:18328522).  Inhibits spore germination in C. sojina, A. niger (at concentrations >50 ug/ml) and P. herguei but not in F. oxysporum and F. solani (PubMed:20831249, PubMed:18328522).  Does not inhibit vegetative mycelial growth (PubMed:20831249).  Inhibits growth of C. albicans and K. marxiannus but not P. membranifaciens or C. parapsilosis (PubMed:20831249, PubMed:23894655).  Probably acts by affecting the cell membrane (PubMed:20831249).  Does not have urease, chitinase, beta-1,3-glucanase or hemagglutination activities (PubMed:18328522, PubMed:20831249).  Does not inhibit trypsin (PubMed:18328522).  Injection into mice produces toxic effects such as dyspnea, tonic-clonic convulsion and death (PubMed:18328522).
What are the official names of this protein?
Soybean toxin 27 kDa chain, SBTX 27 kDa chain.
Protein: SPEE_NEUCR
Sequence: MSEIAHPTIQDGWFREISNMWPGQAMTLKVEKVLHHEKSLYQDVLIFKSTDHGNVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHDCVEEAILCDIDEAVIRLSKQFLPHMSAGFEHPKVKVHVGDGFKFLEDFKNTFDVIITDSSDPEGPAESLFQKPYFQLLHDALREGGVITTQAENQWLHLPLITKLKKDCKEVFPVAEYAYTTIPTYPSGQIGFMVCSKDPNANVKVPLRSWSQEEEEKLCRYYNSEIHKASFILPTFAKKALE
What are the official names of this protein?
Spermidine synthase, SPDSY, Putrescine aminopropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
Protein: SMG7L_ARATH
Sequence: MEANSADQKQKPNFLVEVNNIEKQLWTLIHSKTILHTDVSELYAKAGSTYEQIFKSNLQHEELQEVEFCLWKLHYKHIDEFRKGLKTNDHAKHMKAFKLFLSKAAEFYQNLISKVRGYYHRLSEESGEQKSRFLCHRFYICLGDLQRYQEQYLKAHEHPNWSTAATYYLEAAKSWPDSGNPHNQLAVLATYVSDELLALYHCVRSLAVKEPFPGASNNLLLLFEKNRSSPLQSLSTDAEFNYLNPSEKKVSVKERDLSKAKGELVAGIDLWPLVVRTTSFFFLKSSFDEFGRAFASTIRELDAAFAADDRNLEAMLESYQFMDTARKGPYKILQIVAVFIYIFHNLAEANGSDIVKEEVKLTNLALTMVFIVMGRVVERCLKTTPLDSCPLLPALLVFLDYLPFLLDKVEEEEEECRFDEKSKSAISYFFGKLVDILNQLKVKDKNCPAKTLLALWEDHELKSLAPLAPIHALLDFSSNMDLRESFDRGKELRLQRIISSAIDITTRQKKGSQKWLFFDNQRTHFYTTSGELQSNGELFHGNGEGRNRKCVTIGPVEIIPLENERSVPVEEEEVILLKPLVRCQSAPIYSSGIAAKPLSSDCTTSGNQTTTSNDSLRRTLSLIGSESFSFTQGLKDTDPQHLHLEEGTVSGRPPSLSAWVVDKNKEKGRLGLSKPNGLGPIDETGPVSAFDSLSINSSTEHPASSYSPPTPSAPLLPEDASWFHNDASTNKAESFYDQTRYMELPGIMKPYTNPPFVGISSSEWLRRYRESRNLGPAYSYQAQGTNNLRNFMAHGSSKFSLLARYGTPNDSSQNSTFHPQLYMEDHESRGEKLGNVQQSTTNPYGFSDDPGPFLRFLREKEWLNENGQRLRGPPPAYMNN
What is the function of this protein?
May play a role in growth and development.
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG7-like, Protein SMG7L, Protetin SMG7-like.
Protein: MNMG_SHIDS
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFLQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTRVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_ECO5E
Sequence: MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPDFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYGVEPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGVHETLDELTTRLAEGLLEAAEEAGIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHMMLDEGVYLAPSAFEAGFMSVAHSMEDINNTIDAARRVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.