PharMolix/UniProtQA huggingface dataset:
Protein: OXR1B_MAGO7
Sequence: MSVPSFITAPEFEGGPPQGLSIPFRLRWSKTHPPKEPIVTFKGRTVLVTGANTGLGFEAAVKYAAFGADKIILAVRSIEKGEEAKKRIVERTGRDATDISVLKLDLGEYSSVKDFVSALHEVTPTLDVALLNAGLGNPTYEKSSAGWEMAVQVNVLSTALLAMLLLPLLRSSAAASGAKSHLTFVNSFAHTLVPRDFPLIEGSILKTATDESSWNASSSYNIVKLLAMASVQGFARMEAGEDQQRVIVNSVCPDLCETDLGRKFTGFISSIGKAIFYYLFALSAEEGARCLIGATALGPESHGRFWHHDFLYPFGELAQDQALMKKTWNEIIEAVGRDEPEILQLCRTT
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars (PubMed:18433432).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone (PubMed:29142718).  The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor (PubMed:29142718).  Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1 (PubMed:29142718).  Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable).  The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds (PubMed:31644300).  Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars (PubMed:18433432).
What are the official names of this protein?
Short-chain dehydrogenase/reductase OXR1, ACE1 cytochalasan biosynthesis cluster protein OXR1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: Y1526_YERPB
Sequence: MDHRLLEIVACPVCNGKLYFNKENLELVCKVDNLAYPVRDGIPVLLENEARPLSIDEKHA
What are the official names of this protein?
UPF0434 protein YPTS_1526.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RL35_CHLPM
Sequence: MPKMKSHRGACKRFKATASGRIKRERMNGSHNLEHKNRKRTRRLHQSALLECTKKERQIKRMILA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: TRMB_PSEA6
Sequence: MSQFKSKEEAAESGVYIRKIQSFVKREGRLTKGQEKAIESNWETMGLEHKSGLLDMNEVFGRTAPVVLEIGFGMGKSLVTMAKNEPDKDFIGIEVHRPGIGACLADAQEQGVTNLRVYEHDAVEVLADCIADGSLSRMQLFFPDPWHKKRHHKRRIVQPEFVEKLRGKLAIGGVFHMATDWENYAEHMLEIMAVAPGYKNLSSTSDYVPRPEQRPLTKFEQRGHRLGHGVWDLMFERVA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RS16_CHLL2
Sequence: MVKIRLKRTGRKKLPFYQIVAADSRAPRDGKFLEIVGHYQPTAKPHAVTIKKDRVSYWMQTGAQPTDTVRSLIRSTGLLHELRLRSLGRSEADITAEMEKWQQNQTERRQKRLAVKTRRRQAKKAAEAKGAEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: STX3_ANESU
Sequence: RSCCPCYWGGCPWGQNCYPEGCSGPKV
What is the function of this protein?
Specific arthropod (crab and insect) toxin that inhibits inactivation of voltage-gated sodium channels.  It competes well with the site-3 toxin LqhalphaIT (from the scorpion L. quinquestriatus (AC P17728)) on binding to cockroach neuronal membranes (Ki=21. 4 nM), and inhibits the inactivation of D. melanogaster channel (DmNav1), but not that of mammalian Navs expressed in Xenopus oocytes.  Its activity is synergically enhanced by ligands of receptor site-4 (Bj-xtrIT (AC P56637)).  Its ability to inhibit the channel mutant DmNav1[D1701R] only decreases 5-fold, whereas the inhibition activity is completely lost by LqhalphaIT and Av2 when tested on DmNav1[D1701R].
What are the official names of this protein?
Delta-actitoxin-Avd2a, Delta-AITX-Avd2a, ATX III, Av3, Neurotoxin 3, Neurotoxin III.
What is the protein family that this protein belongs to?
Belongs to the sea anemone short toxin (type III) family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RS8_XANAC
Sequence: MSMTDPIADLLVRIKNAAAVGKQTVKLPSSKIKVAIAQVLKDEGYITDLRVTQAENNKAELEIVLKYFEGRPVIETLKRFSRSGLRQYRGKTELPKVLGGLGIAIISTSKGIMTDAQAREAGVGGEVLCFVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TOLQ_PSEAE
Sequence: MEPNVVDHTSMWSLISNASIVVQLVMLTLVAASVTSWIMIFQRGNAMRAAKKALDAFEERFWSGIDLSKLYRQAGSNPDPDSGVEQIFRAGFKEFSRLRQQPGVDPDAVMEGVARAMRVAISREEEKLEASLPFLATVGSTSPYVGLFGTVWGIMNSFRGLATVQQATLATVAPGIAEALIATAIGLFAAIPAVIAYNRFSARSEMLIGRYYTFADEFQAILHRKVHTSDD
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolQ.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TES_ATEAB
Sequence: MDLETKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSSEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKDKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKNEALGVGDVKLPHEMESQGPNKMHIPGGDRSTTAAVGAIASKSAEHKRTQYSCYCCKLSMKEGEPAVYAERAGYDKLWHPACFVCNTCRELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGEIYVMVNDKPVCKPCYVKNHAVICQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSLECKKMMS
What is the function of this protein?
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton.  Plays a role in the regulation of cell proliferation.  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Testin.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Protein: PROB_BURPS
Sequence: MRSIIADSKRLVVKVGSSLVTNDGRGLDHDAIGRWAAQIAALRGAGKEVVLVSSGAIAEGMQRLGWSKRPREIDELQAAAAVGQMGLAQVYESRFAEHGIRTAQILLTHADLADRERYLNARSTLLTLLRLGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEGDTLVILTDQPGLFTADPRKDPGATLVAEASAGAPELEAMAGGAGSSIGRGGMLTKILAAKRAAHSGANTVIASGRERDVLVRLAAGEAIGTQLIARTARMAARKQWMADHLQVRGHVVIDAGAVDKLTAGGKSLLPIGVVAVQGVFARGEVIACVDDTGREVARGITNYSSAETKLIQRKPSGEIETVLGYMLEPELIHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_PECAS
Sequence: MSVYDKHQALSRLTLGKPTPYHDRYDAALLQPVPRSLNRDPLGIYPDSLPFHGADIWTLYELSWLNNRGVPQVAVGEMHLNAESLNLIESKSFKLYLNSFNQTTFDSWESVRATLANDLAHCAQGDVSVTLFKLSELEGQPLAGFTGECIDDQDIQIDNYNFNADYLATNEQDAPVVEETLVSHLLKSNCLITHQPDWGSVQIHYRGKRINREALLRYIVSFRHHNEFHEQCVERIFNDLMHYYQPEKLSVYARYTRRGGLDINPWRSNTPFNAPNGRLPRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCRB1_HUMAN
Sequence: MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
What is the function of this protein?
(Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.
What are the official names of this protein?
Scavenger receptor class B member 1, SRB1, CD36 and LIMPII analogous 1, CLA-1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, SR-BI.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Protein: TBA1B_PANTR
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFVLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1B chain, Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VG30_ICHVA
Sequence: MMDIFNSVSESINILNNSVAPMDHREEHEGAPSDKPWGVNFSGHDFLVNSTSRSDIITSVEQVDRTGSCPICASKNDQGTSLAEAMESMVATRQLDSAMSFLSMVRPDLANWDVINYHFSHGIKDPIEKLEYQIDTMIDVHYRAGMAIGRDFAMMVTANGSQFVSPNEKNIKCLSSLTTGLTKLIQVRGDIRKMTTSKKNKRGTAAPL
What are the official names of this protein?
Uncharacterized protein ORF30.
Protein: SYT_PASMU
Sequence: MPIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEIITAKEEDGLEIIRHSCAHLLGHAIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDALEKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAILDENIDRCDTPALYHHEEYVDMCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAAKRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWEKTGHWQNYGDLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTACIKMVYDIYSTFGFENIQVKLSTRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQCGTIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPTQAIVMNITDSQSDYVQKVVKTLSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEIEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLLGEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETN_PROMP
Sequence: MMIFQIGWAALAAIFTFSIAMVVWGRNGDGSIDI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: B2KB8_SICCD
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDFDKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPLVEDYEFIRAFKDTLKNEGYESYNDRVGINFTGNEDLDKIRDVLEILGIHKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1bviii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SPB10_OTOGA
Sequence: MDPLASSISQFALEFSKELAASAAGKNIFFSPWSISSALAMVYLGARGTTAVEMAKVLQLNRDQADKTGPESEKKRKMEFNLGKAEEIHCDFQTLISEILKPTDAHVLKTANGIYGEKTYPFHNKYLEEVKTYFGAEPQSVNFVEASDQIRKEINSWVESQTQGKILNLLPDDSVDSTTRMILVNALYFKGTWEHQFLAQNTTEKPFRINETTSKPVQMMSMKEKLHVFHIEKPQATGLQLYYERRDVSLFILLPEDLGGLEQLEKAITYEKLNEWTSADMMELYDVQLSLPKFKLEESYDLKSTLSSMGMSDAFNPSKADFSGMSLERNLYLSNIFHKVFVEINEEGTEAAAGTGSEVGFRIKYPSIEFNVDHPFLFFIRHNKTNSILFYGRFCSP
What is the function of this protein?
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF.  May regulate protease activities in the cytoplasm and in the nucleus (By similarity).
What are the official names of this protein?
Serpin B10.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TPA_RANTE
Sequence: FLPLIGRVLSGIL
What is the function of this protein?
Amphipathic alpha-helical antimicrobial peptide with potent activity against Gram-positive bacteria, weak activity against Gram-negative bacteria, and moderate activity against fungi (PubMed:9022710, PubMed:15513914, PubMed:16867990, PubMed:18255189, PubMed:18370376).  Mainly acts by causing membrane permeabilization (Probable).  Is also able to kill S. aureus (both wild-type and MRSA) that are internalized in human keratinocytes without injuring host cells (PubMed:24514087).  Rapidly inactivates both channel catfish herpesvirus (ED(50)=15 uM) and frog virus 3 (ED(50)=58 uM) over a wide temperature range (PubMed:15193922).  Also displays anti-leishmania activity by damaging parasite membrane (PubMed:15513914, PubMed:25668079).  Acts synergistically with temporin-L which improves temporin-1Ta activity by preventing its self-association in lipopolysaccharides (LPS) (PubMed:16867990).  Does not show hemolytic activity (PubMed:15513914).  In vitro, stimulates insulin release from pancreatic beta-cells in a dose-dependent manner without increasing intracellular calcium, protects beta-cells against cytokine-induced apoptosis and augments beta-cells proliferation (PubMed:29349894).  In vivo, intraperitoneal injection together with a glucose load into mice does not have effect on plasma glucose levels (PubMed:29349894).  In vivo, when tested on mice with methicillin-resistant S. aureus (MRSA)-infected wounds, this peptide inhibits bacterial growth and shows wound healing effect (PubMed:18255189).  In vitro, promotes cell migration and wound healing (PubMed:24514087).
What are the official names of this protein?
Temporin-1Ta, TA, Temporin-A.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Target cell, target cell cytoplasm.
Protein: BBP1_YEAS2
Sequence: MNQEDNTGGGGIFGLFKWTKDALFGTDISPSMKYKDQEERRDRSRYAQDDTNFSMKFGNDSNRRSTNLSRSNSWSGLDSTLHRKYELLPEYNENGFNSIVNGDHHSKERIRSLRSPAPIVPREPLRNEPTDTFGHRLHTKRRTINELSNSQIPFIPPQEDDPLLSKLFNKDGVNEVRRSPYKLSVKDIPGKFPSPLTKRDEIDNYYVRDEDACHNNREYKKAYFDLFAQMDLNSRDLEDLCEDVREQREQFHRNEQTYKQAYEEMRAELVNELKKSKTLFENYYSLGQKYKSLKKVLDQTISHEAELATSRERLYQEEDLKNFEIQTLKQRLSDLELKYTNLQIEKDMQRDNYESEIHDLLLQLSLRNNERKDTSAGSNIFSTGQYDRTPFHNGNNSYDSNSHSWDTDYLKNIDGFIER
What is the function of this protein?
Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.  Connects the central plaque of the SPB with the half-bridge.  Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity).
What are the official names of this protein?
Spindle pole component BBP1, BFR1-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the BBP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associates with the periphary of the central plaque.
Protein: RL30_CORK4
Sequence: MALKITQVKGTVGTRKKQKDNLRSLGLKRIRHSVVQPDTPQVRGMINVVRHLVTVEEVAGE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: Y2085_LISMF
Sequence: MENDRQAIVVWMNHLKQVRSLKRFGNVHYVSRKLKYAVLYCDMAEVEDISNKVSRFHYVKRVEMSFRPFLKTEYESKKEMMYEHKNEDVQISI
What are the official names of this protein?
UPF0298 protein LMOf2365_2085.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_ACIAC
Sequence: MHSIPADTGHTPSRAPAGNGSPPADVAFPKAIKSYVRRAGRTTTGQAKALETFGSQFVLDYTPGPLDAQAAFGRAAPLILEIGFGMGEATAHIAGVRPQDDFLCCEVHEPGVGALLKRIGERGLTNIRILQHDAVEVIDHMLPEGSLDGVHIFFPDPWHKKRHNKRRLVQPPLVAKLARRLKPGGYLHCATDWQPYAEQMLEVLSAEPLLANSADGYAPQPDYRPLTKFENRGLRLGHGVWDILFRRVA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: SNX27_HUMAN
Sequence: MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
What is the function of this protein?
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.  Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes.  SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling.  SNX27 also binds with the WASH complex.  Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)).  May participate in establishment of natural killer cell polarity.  Recruits CYTIP to early endosomes.
What are the official names of this protein?
Sorting nexin-27.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
Protein: PSIF_DICDI
Sequence: MKYLFIAIILILYCSFTKADQKKFLVNMYDNDPLFSPDFENANGAQTGLVKKKLGSDGKPIPANYDMKDPNGNYYIKNATTFKSWFNEVAGVSILVPFELVLTQTAGSQNYYSYSNTSFFPLNELGWYNPSIKGDYEFKKYQDSNKKEQNFHFCMHASFIMSTNCKEVFKFKGDDDVWVFINDVLVLDIGGVHGVQDGTVDMANLPEKIHDSTNSKLGNCKNGTYPFDFFYCERHTKASNCLFETNMGFTCSYYDYCGICNGKGECCTDVKLNQCYTKKCPLPNSLPNGATNYQDYMTIVPTNTCGGTDKCKIYSCNNSTGCEFKQKSCDDGDKCTKDACDSKTGYCSNIPTNPSVVTSCLKSGCDSTTGNYSTPTNCDDKDPCTIDSCINGQGCVHTKACDDEDPCTTDSCSADGKCTHTAIAKCNSDCPSCPSKKCKITSCSEDSGACNYVDMVFASPSECYKATCDPETEEAIYSPIDSSCDTSDSCFTAQCNLNKTCTRVPAINCDDNNECTTDSCSGGSCSNTAIACDDNDPCTIDTCSPSEGCIFTPIVCEQTSLCNTFTCSVGKCVPTPITCSSSVKCQDSICREGVGCVYFNRTCPPDDDCSSAYCSMETGKCISKAYDPLPFSCQSTAVKVGVGIGAAAAAGIAIGGAVAAGLAIFGGKKAYDTWKTSRGNVMTGSQSNPLYTQNQNNGNNPLYSAPAE
What is the function of this protein?
Acts as a quorum sensing protein regulating discoidin gene expression during growth and development.  D. discoideum is a single-celled amoebae and switches to multicellular development when food becomes limited.  As the growing cells reach a high density, they begin expressing discoidin genes.  The ability of psiF/dicA to induce discoidin gene expression when present in conditioned medium, suggests that it allows cells to sense their local density.
What are the official names of this protein?
Protein psiF, Discoidin-inducing complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the prespore-cell-inducing factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Secreted.