PharMolix/UniProtQA huggingface dataset:
Protein: DAD2_ASHGO
Sequence: MVPEDVYQSKKSELLYLQKVTGLTDTLKAQLDELSKQVHQMHDNAECVSSVLKNWDSILNSISQATLSLLQYTENDYEVGAWSNGSRPEADKEPPLPETLVRVNVANESQE
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD2, Outer kinetochore protein DAD2.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: RRAA_YERPP
Sequence: MKYDTSDLCDIYHEEVNVVEPLFSNFGGRTSFGGKITTVKCFEDNGLLFDLLEENGLGRVLVVDGGGSVRRALINAELAELALKNEWEGIVVYGAVRQVDDLAELDIGIQAMAAIPVGAADEGVGESDIRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODN_STRSO
Sequence: MLSRLFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAIQEKMAANDDLHFQIRATVIKEQRAELAKHHLDVLWSDYFKPPHFESYPELHTLVNEAVKALSAAKASTDPATGQKALDYIAQIDKIFWETKKA
What are the official names of this protein?
Superoxide dismutase [Ni], NiSOD, Nickel-containing superoxide dismutase.
What is the protein family that this protein belongs to?
Belongs to the nickel superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4029_EMENI
Sequence: MPHLPELSKQEPSANTLVDNYRAKGEDLENSHHNNESRLAEGVHYDRNKAPALQEREKASTEKVNVEGGGASSSMVDNIRRGNPSGVA
What is the function of this protein?
Involved in osmoadaptation.
What are the official names of this protein?
Uncharacterized protein AN4029.
Protein: NADK_CLOK5
Sequence: MKNIGINVNTTKDPNKEMLNFIIESIKNIDKSVNIKTYENCMGLDENESSSLDVIIVLGGDGTILNTSRNVLRSKTPILGINIGHLGFLAQVEINSVEAALEKLFRGEYTIEKRDMIQCTYNEGNKIKRYDGLNDVVLYRGIKSRIQRYDVYINDAFYNSFSGDGIIICTSTGSTAYNLSAGGPIIHPLLDVLCLTPMYSQFFASRSIVLDSRSLISISIEKNYEDSFLSIDGQKWVAVNGSQTIKINKSKNKRRLIKFDDAYFNTLREKIIFNAKGCEGGIL
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB31B_XENLA
Sequence: MAVCARLCGVGQSGGCRRRRQRKGAGNDPELEDEEEEDEVRIEAEVLVEGQAAVAPLRPRSLLQLPPEILVEIFSSLPGTELPSLAQVCRKFRQILTTDTIWKRRCKQEYGVCENLRKLEVTGVSCHDVYVKLLHQYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDEGMRLKPVFRIHLMERNNATVECMYGHKGPHNGQIQIVKKDEFSTKCLQTDYHRMSGGRQEEFRTWLREDLGRTLEDIFHEHMQELILMKFIYICQYDKCLTYRRIYHPPNRPDDLLNPGFFKGTYGSHGLEIVMFSFHGTIAKATKITGDPNVPAGQQTLEVDLTRPVQLPDVEHLRNFDEISRLILDVQSQIQREQRQTGNEEDDGKGAGPDRAEHSQQPAPVHRPAKEDVNGVDNADDREQKPPNVQSFVLPAGVMARNEEYPRSCKMCFYGTGLIAGHGFSSPERTPGLFILFDEDRFGFIWLELKSFSLYSRMRDRFQHSEAPSLEAFDEMLQHMQSWTT
What is the function of this protein?
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage.  Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).
What are the official names of this protein?
F-box only protein 31-B.
What is the protein family that this protein belongs to?
Belongs to the FBXO31 family.
Protein: VSPP1_GLOHA
Sequence: MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHRFLALVFNSSGFLCSGTLINQEWVLTAAHCDMENMRIYLGVHNESVQYDDEQTRVPEEKFFCLRSNNDTKWDKDIMLIRLDSPVNNSAHIAPLNLPFNPPMLGSVCRIMGWGAITSPNEIYPDVPHCANINLLHYSMCQAVYPGMPAQSRILCAGIQTGGIDTCSGDSGGPLICNGQFQGILHAGGNPCALPRAPGLYTRVFDYTDWIENIIAGNTDASCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease PTLE1, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KCY_ALKMQ
Sequence: MTFKQIAIDGPAGAGKSTVAKKLAALLGYTYVDSGAMYRALTYWALKNDINIHNVEAIVNLCTSIHITFINQDIAVNNQIVNTEIRSPEVNNNVSHIAKIPEVRKHLVSLQKCIALSQNVIMDGRDIGTHVLPDADIKVFLTASTQERAQRRYIELVEKGIQTSLMEVEQGIIQRDQMDSKRQYAPLTQADDAVVIDSTGKSIDAIVEEVLRIFNGKERG
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_BART1
Sequence: MVSLGVFARKFFGSAYERRLKVLRQKVAQINALEEQFVKLSDEQLCQKTDAFRKRLSEGENVDSLLPEAFATVREAAKRVYDMRPFDVQLIGGMVLHDCGIAEMRTGEGKTLMATLPIYLNALEGKGVHVVTVNDYLASRDAETMGKIFSFLGMTTGVILHDLDSDARRAAYACDITYATNNELGFDYLRDNMAFDRSQMVQRGHHYAIVDEVDSILIDEARTPLIISGPLEDRTDFYNLIDTFIPALIPEDYEIDEKQKTTTFTEVGTEKIEKMLEQAGYLKGESLYDIENVAIVHHVNNALKAHKLFVRDKDYIVRNDEIVIIDEFTGRMMPGRRYSEGLHQALEAKEHVAIQPENQTLASITFQNYFRMYRKLSGMTGTAATEAEEFRNIYGLDVVEVPTNLPVQRLDEDDEIYRTAEEKYRAIVRDIRQAHEKKQPILVGTTSIEKSEQLAERLRKEGITDFKVLNARYHEQEAYIIAQAGVPGALTIATNMAGRGTDIQLGGNVEMRIRQELQDIPEGPERTAKIEEIKKDVKQLKEKALAAGGLYVIATERHESRRIDNQLRGRSGRQGDPGRSKFFLSLQDDLMRIFGSNRMDGMLQKLGLKENEAIIHPWINKALEKAQKKVEARNFEIRKNLLKYDDVMNDQRKVIFEQRMEVMNADDLSEMIHEMRNDVVEDLVETYIPSGTYSEKWDVKALEEELQQLFNLELPVKEWAKEDGIAEEQILERILDAVTKLEDERTERYSPEVMAYFQKAVLLETIDTLWRENLVSLDHLRSVVGFRGYAQRDPLNEYKTESFELFQSMLKNLRRIVTSKLMRFEIIQQPTEPSMPEQTGADSSVFNDQNQENAPPLWARSQENRFVNPQDRDPNDVTTWGKVGRNERCPCGSEKKYKHCHGAFV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: Y1069_LACH4
Sequence: MAYRESFYRYLMTQRDADSSDEIAQFANNAQHDLTFPKQEQDYEKLSDYLELNASYLPSMYIFDRAYRMYEDKMMY
What are the official names of this protein?
UPF0346 protein lhv_1069.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: CH10_SYMTH
Sequence: MNVKPLGARVVIKPLEKEERTKSGIVLPDTAKEKPQQGKVIAVGPGRTLESGTKVELEVKEGDTVIFSKYAGTEVKIDGEEYIILDGERDILAIVQG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_AQUAE
Sequence: MRIEEFDYELPEELIAKYPAVPRHSARLMVLNRKDQSIKHDTFINLPDYLEEGDLLVFNNTKVIPARLYGRKPTGGRVEVVLTDFIKPDEWKALIGGKKIRPGLVIEVAPDFKVEVLEHIEEGKFRVKLLGEEPLKLIDKYGHIPIPPYLKREEEPIDRVYYQTIFAKEKGAVASPTASLHFSEELLEKLKEKGINFAFITLHVSYGTFKPVKVERVEEHRVDPEYVKIPKETVEKIKETKEKGKRVVAVGTTVVRALETKPFEPFEGWTDLYIYPGFKFKVVDAMITNFHLPRSSLLILVSAFAGREFILKAYREAVEKRYRFYSYGDGMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPED_ECO55
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSDDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: CDC73_RAT
Sequence: MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMLVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
What is the function of this protein?
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways.  May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.  Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling.  Involved in polyadenylation of mRNA precursors (By similarity).
What are the official names of this protein?
Parafibromin, Cell division cycle protein 73 homolog, Hyperparathyroidism 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CDC73 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOC_BRUA1
Sequence: MSEEALGELSGYIRERLGDAIEEANLAYGELTLCVPVASLIGVLTLLRDDVQCQFVNLTDISGVDYPQREKRFDVVYQLLSPRQNQRIRVKVQADEDTLVPSAVPVFFGAEWYEREAYDMYGILFSGHPDLRRILTDYGFEGHPLRKDFPLTGFVEVRYNDELKRVVYEPVQLRQEFRNFDFLSPWEGTDYVLPGDEKAKTN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SIGE_MYCTO
Sequence: MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released (By similarity).
What are the official names of this protein?
ECF RNA polymerase sigma factor SigE, ECF sigma factor SigE, Alternative RNA polymerase sigma factor SigE, RNA polymerase sigma-E factor, Sigma-E factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: G6PI_VIBA3
Sequence: MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLIDAETMQHLFALANETEVKSAIEAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPAVNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSDLGPYMVTEALTPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKHFAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHEMDNHFASTEFESNIPVILALIGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGKFVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPSDFIAPAISHNPASDHHQKLMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINPRSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNGLINAFKALKA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTPA_HETCR
Sequence: ALAGAIIAGASLTFQILDKVLAELGQVSRKIAIGIDNESGGSWTAMNAYFRSGTTDVILPEFVPNQKALLYSGRKNRGPDTTGAVGALAYYMSNGNTLGVMFSVPFDYNLYSNWWDVKVYSGKRRADQAMYEDLYYSNPYRGDNGWHQKNLGYGLKMKGIMTSAGEAIMEIRISR
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.
What are the official names of this protein?
DELTA-stichotoxin-Hcr4a, DELTA-SHTX-Hcr4a, Cytolysin RTX-A.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: APT_CUPPJ
Sequence: MADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNPKTLRVLIDVFVHRYMDAQLDLVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGAAIVDLPELGGSKLLQNAGLPLFTVCRFDGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10B_YEAST
Sequence: MLMPKQERNKIHQYLFQEGVVVAKKDFNQAKHEEIDTKNLYVIKALQSLTSKGYVKTQFSWQYYYYTLTEEGVEYLREYLNLPEHIVPGTYIQERNPSQRPQRRY
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102).  eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641).
What are the official names of this protein?
40S ribosomal protein S10-B, Small ribosomal subunit protein eS10-B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS10 family.
Protein: HBB_CEBCA
Sequence: VHLTAEEKSAVTTLWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSTPDAVMNNPKVKAHGKKVLGAFSDGLTHLDNLKGTFAQLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FDHD_STAAW
Sequence: MNKDVSLGQPIVRYEDGKLFNTTDQYVTEFPLTIMVNGEEFATVICSPTNLEELVIGFLASEGAILKRDELKSVLIDDSKGFAHVELNKDLGDRFQYSTKRMIASCCGKSREFYFQNDAAIAKTSMSKITLTPMQIINMMTRLQSASHIYQETGGLHNAAISDGLTFFVHRQDIGRHNALDKLYGFCIQRHITVRDKVLIFSGRISSEILIKAAKIGVGVILSKSAPTTLAVTLANDLNITAVGFIRNGGFNIYSHPERIIDSEQ
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_SRV1
Sequence: MNFNHHFTWSLVIISQIFQVQAGFGDPREALLEIQQKHGKPCDCAGGYVSSPPTNSLTTVSCSTYTAYSVTNSLKWQCVSTPTTASPTHIGSCPSQCNSQSYDSVHATCYNHYQQCTIGNKTYLTATMIRDKSPSSGDGNVPTILGNNQNLIIAGCPENKKGQVVCWNSQPSVHMSDGGGPQDKVREIIVNKKFEELHKSLFPELSYHPLALPEARGKEKIDAHTFDLLATVHSLLNVSSQRQLAEDCWLCLRSGDPVPLALPYDNTSCSNSTFFFNCSNCSCLITPPFLVQPFNFTHSVCLYADYQNNSFDIDVGLAGFTNCSSYINISKPSSPLCAPNSSVFVCGNNKAYTYLPTNWTGSCVLATLLPDIDIIPGSEPVPIPAIDHFLGRPKRAIQFIPLVIGLGITTAVSTGTAGLGVSLTQYTKLSHQLISDVQAISSTIQDLQDQVDSLAEVVLQNRRGLDLLTAEQGGICLALQEKCCFYANKSGIVRDKIKNLQDDLEKRRKQLIDNPFWTGFHGLLPYVMPLLGPLLCLLLVLSFGPIIFNKLMTFIKHQIESIQAKPIQVHYHRLEQEDHGGSYLNLT
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: CBH1_SCHPO
Sequence: MPPIRQAVSLAEKKAIRDYYNQSAHRIPQKEVTEWFRKTYNKDLSQSTISEILSPKYSYLDDGSVRLGDIKKIRAPKFPLLDNAVYEWLQQREVEGLPISGDMIKQAATRFWSKIPAYASLPLPDFSNGWLDKFRRRHYIQQSAVNQALESIKFEVFREYPVHIQEFIRPYAQKDIFCVGGTSLFWKLTPNKQNLDYQEIQGMKRGKAKVSLIMCCNADGSERLPLWIVGYAQNPRSFEQCGIFPKSMNFEWKWNGRASISPIIMEEWLRWFDTRMQGRKVLLMLESNDTYQFGVESVRRFKGGFQNTSVFRIPEKTLDIKSPFEQGIVDTFKANYRRYWLQYSLNQINILRDPLKAVNVLKAIRWMLWSWNFGVSEKTIQASFLRSGLLGPHSEAEGQGMESYQKAIMEIGNLISSKGSEAVKQINEYIRPSEEDETKLHQDAVDTVAAEFLEERRFESDEEEDVEPQISNVEAAMAFEVLIKYFEQHENGDPSFVLDLYRRQRVIAPNNLIA
What is the function of this protein?
Binds to centromeric K-type repeat DNA and ARS3002 DNA.  The CBH-binding consensus sequence is Py-Pu-A-T-A-T-Py-Pu-T-A.
What are the official names of this protein?
CENP-B homolog protein 1, CBHP-1.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere.
Protein: RSGI3_ACET2
Sequence: MDNIGVIIKIEGNEAIVMTDDCSFKKVPIKDGMHPGQKILVPNNEVIQKENKSIKRISAVATGIAAVFLMVLSLIWINKPGRPDGIYAYIDVDINPSLNFLIDREGKVKALNPLNDDAQEIIRGVEFEDMFFSEALTQIIKISKAKGIIDENKTNYVLICAALDDNYNLQSDDKSRAQTEFEEFLDGIRESIEKACGNTVIPQTVKVPFEYLKMAKQNDVSMGRYLVYQKLEDIGVNLSIEELKSLDIDEILKKYGVGFDELFKSEYTELPYGTLQTGEDSVVSTEDVPVSPKNAFETMAVPTNTPSISTKPSATPAENPTPKLTQKPTPVPAKTGERTSTTPTPTPAPTVRNGTGSGLRGEYYNNMDFSRFQFVRIDPCIDFDWGEGTPDQSIGKDTYSVRWTGKVEPRYSETYTFYTVTDDGVRLWVDGVLLIDKWKSQSATEHSEQIYLEAGKKYDIKMEYYQHVRAASAKLMWSSKSQQKEIIPSSQLYPSDGPLPQKDVNGLSAEYYGDAELKDKRFTRIDDAINFNWDKDFPVGELKDGKFSVRWVGKIDTRYTEEYTFHTVANGGVRVWINNVLIIDNWQNQGKEAENSGKIELKAGRQYDIKVEYCNYGEPAFIKLLWSSQRQKKEVVPSKNLFAD
What is the function of this protein?
Anti-sigma factor for SigI3.  Negatively regulates SigI3 activity through direct interaction.  Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI3 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI3.
What are the official names of this protein?
Anti-sigma-I factor RsgI3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.