PharMolix/UniProtQA huggingface dataset:
Protein: GLPG_SALSV
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y133_METJA
Sequence: MNREIMLIFGTAGVPISAEDEFKAVDVLRKLNLGAMELEFVKGVYMKEDYAKKLKEYGEDIIFSAHAPHYINLNANEEEKVENSIRRIIKTAKVLNNCGKNLVFHPGYYLKRSKEVTYNRIKSNIQRILDKLEALNLNVMLRPETTGKTTQFGDIDETLKLCFELNILPCIDFSHIYARSRGVINDYNSFYKILEKVENVLGKEAIKDMHIHLSGIEYGKGGERRHLPLNESNFNYRDVLKALKDFDASGTVICESPMLEYDAVLLMKCYNEL
What are the official names of this protein?
Uncharacterized protein MJ0133.
Protein: YAEH_ECO5E
Sequence: MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKGEFFAKSVKFKYPRQRKTVVADGVGQGYKEVQEISPNLRYIIDELDQICQRDRSEVDLKRKILDDLRHLESVVTNKISEIEADLEKLTRK
What are the official names of this protein?
UPF0325 protein YaeH.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: YUAR_ECOLI
Sequence: MRVIMKPLRRTLVFFIFSVFLCGTVSARQIEWQSCMTSPYSDWFGKESSSPELLCGYLSVPLKYTDTGKDVSDENIPLVRLAMTKLPAKSKRKGSVIIISGGPGLPGINPYINFDWPVTNLRESWDIIGFDPRGVGQSFPAINCQQSNQERLVNVSEKQLILQKINACIHNTGAEVIRHIGSHEAVYDIERIRQALGDKQLTAVAYSYGTQIAALYAERFPSSIRSIVFDGVVDIDDLNDNFSWKLRQAHSYQETFDRFAAWCARTKSCPLSSDRNQAIHQFHQLLLKLHNSPLTDSRGESISSDDLISLTTELLLWRSSWPTLATAVRQFSQGIVSNEIETALNSSIASEKVSDALGVILCVDQSDEQLSQEQRKSRKKALADAFPAVNFEREQSDLPEFCELWPIHRDLQQTRLKNTVLPSGLLFVAHKYDPTTPWINARKMADKFSAPLLTINGDGHTLALAGTNLCVDEAVVRHLLFPGKSEDITCQGSGTGDTN
What are the official names of this protein?
Putative hydrolase YuaR.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
Protein: RNB_YERE8
Sequence: MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHDFQSGDWAVAEMRRHPLKGDRGFNADLTAFITDGEDHFVPWWVTLARHNLEREAPVMVESALHDANLQREDLTALNFVTIDSASTEDMDDALQVQDNGDGSLLLTIAIADPTAYVDENSELDLIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTIAADGTLGEDIHFSAAWVESKAKLVYDEVSDWLEGSGDWQPQNADIAEQITLLKRVCEARSHWREQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAAIALRDNLGFGIYNVHTGFDPALVEQAANVLQANGVEADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTVPGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAIITGQQAEKPQDEITVQLAERRRLNRMAERDVGDWLYARYLQPMAGTDTRFPAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDEMVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVVARPVV
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_SYNC1
Sequence: MKRIGIYAKCNHPDAVMVARDVVGWLRGRGLEVFLEKKLAQDVGDAEQSHDRGSIPGMVDLIIVLGGDGTLISVARQVCGRDVPILGVNLGSLGFLTEITRGELYLSLEKVLKGEFSLSDRMMLEAVVWRHGLEAGRFSVLNDVVINKGAIARIIDMEVSVDTAYLTTFKSDGLIIATPTGSTAYNLSAGGPIISPGLHCLVVTPICPHMLANRPLIVSDTACIRIEMKLRDQDVVLTADGQVGMALEAGDVVEIRKADRCTRLIKSPSKEYFEVLRTKLGWGER
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_CAMJR
Sequence: MDFYSLIFLSCALGMDAFAVSLCKGFSVKKLHLKHYLIVGIYFGGFQALMPTIGYFIGITFASFIASIDHWIAFILLSLIGLKMIKESLENENCDSNANQFGFKTMLALAIATSIDALAVGVSFAFLNVNLLLAIFLIGIITFILCIIALKIGNKFGIYLKNKAELLGGLVLIILGVKILIEHLFFD
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ORF2_TTVD1
Sequence: MDPAKIWWHSCLLSHKSWCNCTEPRNHLPGWPTSEGTSTEDGDIITDAEMLTLAEDTEG
What are the official names of this protein?
Uncharacterized ORF2 protein.
Protein: URE1_STAS1
Sequence: MSFKMTQSQYTSLYGPTVGDSVRLGDTNLFARVERDYATYGDEAAFGGGKSIRDGMAQNPNVTRDDKQVADLVITNAMIIDYDKIVKADIGVKNGYIMKIGKAGNPDIMDNVDIIIGATTDIISAEGKIVTAGGIDTHVHFINPEQSQVALESGITTHIGGGTGASEGTKATTVTPGPWHLHRMLLAAESLPLNIGFTGKGQAVNHTALVEQIHAGAIGLKVHEDWGATPSALDHALQVADDYDVQIALHADTLNEAGFMEETMAAVKDRVLHMYHTEGAGGGHAPDLIKSAAYANILPSSTNPTLPYTVNTIDEHLDMVMITHHLNASIPEDIAFADSRIRKETIAAEDVLQDMGVFSMVSSDSQAMGRVGEVITRTWQVAHRMKEQRGLLDGDSEYNDNNRIKRYIAKYTINPAITHGISDYVGSIDEGKLADIILWEPAFFGVKPDVIVKGGLINAAINGDANGSIPTSEPLKYRKMYGQLGGNLQSTSMTFVSTTAYENDIGKLLGLKRKLRPVHNIRKLSKKDMKNNNATPDLDVDPQTYEVFVDGEKITSEPATELPLTQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN_MORIN
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CR025_HUMAN
Sequence: MKMEEAVGKVEELIESEAPPKASEQETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRVYESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSRSESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDSSTSDSDLTCDSSTSSSDDDEEVSGSSKTITAEIPDGPPVVAHYDMSDTNSDPEVVNVDNLLAAAVVQEHSNSVGGQDTGATWRTSGLLEELNAEAGHLDPGFLASDKTSAGNAPLNEEINIASSDSEVEIVGVQEHARCVHPRGGVIQSVSSWKHGSGTQYVSTRQTQSWTAVTPQQTWASPAEVVDLTLDEDSRRKYLL
What is the function of this protein?
AMPK substrate important for exercise capacity and skeletal muscle function.  Required for normal contraction-induced signaling.
What are the official names of this protein?
Protein C18orf25, ARKadia-like protein 1.
Protein: DNBP_METTH
Sequence: MTDLEEIRRKKMLELQQKAQQQAMEAEAQEQMRQQLEMQKKQIMMQILTPEARSRLANLRLTRPDFVEQIELQLIQLAQMGRVRSKITDEQLKELLKRVAGKKREIKISRK
What is the function of this protein?
DNA-binding protein which can interact with a randomly chosen 20-mer of double-stranded DNA.
What are the official names of this protein?
DNA-binding protein MTH_1615.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: MINC_SHEDO
Sequence: MSKQSLELKATSFTLSVLHIKNHDLIALAAELDQKLSQAPQFFIGAPLVINLKAVEKHCLDLSALKTLLMDRQLIIVGITEASPELIEQARALGLAVIKSGKQATTAPLPQRETKVVKQNVRSGQQIYAKNADLVIFGAVGNGAEVIADGSIHIYGALRGKAMAGAAGDHNSVIIANSLEAELVSISGQYWLAEHLQQHSLDKRACIRRDGESLMVETLPQ
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RL30_METRJ
Sequence: MAQKTLRVEQIGSPIRREASQRQTLIGLKLNKLHRVSELEDTPSVRGMIRKVAHLVRVHGDVA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: FTSK_STRCO
Sequence: MASRPSAAKKQPAKKAAAPAKGPVKKAAAKKAPAKRAPAKKAAARKPAPQPAPNPTNGVYRLVRALWLGLAHGVGAVFRGIGQGAKNLDPAHRKDGVALLLLGVALIVAAGTWADLKGPVGDLVEILVTGAFGRLDLLVPILLGAIAVRLIRHPEKPEANGRIVIGLSALVIGVLGQVHIACGSPARSEGMQAIRDAGGLIGWGAATPLSYTMTDVLAVPLLVLLTVFGLLVVTATPVNAIPQRLRQLGVRLGVVHAPETDEFTNDDERYDEQWREALPARPRKRAQPAAAEPYDPDAAEQEALSRRRGRPRRSAVPQPEMNRPMDAVDVAAAAAAALDGAVLHGMPPSPLVADLTQGVSTGDRESTTPTPTPVPAARPQPGKLKKDATKAAGGEPAGGAVPDLTKTPLPKERDLPPRAEQLQLSGDITYSLPSLDSLTRGGPGKARSAANDAIVASLTTVFTEFKVDAAVTGFTRGPTVTRYEVELGPAVKVERITALTKNIAYAVASPDVRIISPIPGKSAVGIEIPNTDREMVNLGDVLRLAESAEDDDPMLVAFGKDVEGGYVMHSLAKMPHMLVAGATGSGKSSCINCLITSIMMRATPEDVRMILVDPKRVELTAYEGIPHLITPIITNPKRAAEALQWVVREMDLRYDDLAAYGYRHIDDFNRAVREGKVKPPEGSERELQPYPYLLVIVDELADLMMVAPRDVEDAIVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLIGKGDGLFLPMGANKPTRMQGAFVTEEEVATVVQHCKDQMAPVFREDVTVGTKQKKEIDEDIGDDLDLLCQAAELVVSTQFGSTSMLQRKLRVGFAKAGRLMDLMESRSIVGPSEGSKARDVLVKPDELDGVLAVIRGESEG
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: TKT2_ALIF1
Sequence: MNRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPANPEWADRDRFILSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYTFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPTLICTKTIIGFGSPNKQGTHDCHGAPLGADEIKAAKAQLGWEHGAFEIPQEVYAEWDAKETGAAKEASWNEKFAAYEAAYPELAAEFTRRVNGDLPKEWEEKASAIIADLQANPANIASRKASQNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDFSGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSALIFSRQNLAQQERDAKQLANIAKGGYILKDCEGQPELILIATGSEVELAIEAAAQLTAEGKAVRVVSMPSTDAFDKQDEAYREAVLPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAPADELFKMFGFTTENVVNTAKELLA
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase 2, TK 2.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: YPKP_BACSU
Sequence: MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQPKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANPKVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYHLPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA
What are the official names of this protein?
Uncharacterized protein YpkP.
Protein: URAD_HUMAN
Sequence: MDIEKVNSMDLGEFVDVFGNATERCPLIAAAVWSQRPFSDLEDLEKHFFAFIDALAQSGQEGILRCHPDLAGSELQRGTLTAESQREQSGAGLRSLGADERLRLAELNAQYRARFGFPFVLAARFSDRTAVPRELARRLLCPSAQELRTALGEVKKIGSLRLADLLRADPAKL
What is the function of this protein?
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
What are the official names of this protein?
Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, OHCU decarboxylase, Parahox neighbor, Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the OHCU decarboxylase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: KDSA_RHIME
Sequence: MMETNSRVVVGEGAGQVVFSQKERLTLIAGPCQMESREHAFMIAGELVELCRSLGLGLVYKSSFDKANRTSLSGKRGIGLDKAMEVFADLKREFGFPVLTDIHTEEQCAAVAETVDILQIPAFLSRQTDLLVAAAKTGRTINVKKGQFLAPWDMKNVLAKFTESGNPNVLLCERGASFGYNTLVSDMRSLPIMAALGAPVVFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGVFVETHEDPDNAPSDGPNMVPLKDMPRLLEKLLAFDAVAKA
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMP25_MOUSE
Sequence: MCFPGSQISPARLYYLVSAPWICTGSLTSSRLPRRRESGPLRVPPRSVQAERILRLPAFGLPLLALLLVPLLPVRAQNPDAKVVSMGVEWLTRYGYLPPADPVHAQMQSLEKLQDAIKVMQRFAGLPETGQMDPMTIKTMRKPRCSLPDVLGAAGLVRRRRRYSLSGSVWKKRTLTWSIRSFSQKSQLSPQIVRTLLSYALAVWATESGLTFQEVNSQYQEPDIIIHFARAYHQDSYPFDGSGGTLAHAFFPGEHPISGDTHFDDEETWTFGSTDDNGIDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPATYRLPQDDRDGLQQLYGRVSQNPNARPTRKPLVPPPQPPAMPPDSPATPVPDRCEGNFDAVANIRGEIFLFKGPWFWRLQPSGQLVSPRPAGLHRFWEGLPTHVKVIQAAYARPLDGRIILFSGPQFWVFQERQLEGAARPLVEFGLPPGEDVDAVFSWPHNGKTYLIRGQKYWRYDEVAARPDPGYPRALSLWDGAPFAPDDVTISNTGDTYFFKGTHFWRFAEGSVKAESDSPQPIGPKWLDCPAPNSDPRVTSPPKTTSKTRSCDCHCELNQASEQLSPLLLPLLPLVAGEVFSY
What is the function of this protein?
May activate progelatinase A.
What are the official names of this protein?
Matrix metalloproteinase-25, MMP-25.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: TBKB1_HUMAN
Sequence: MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI
What is the function of this protein?
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
What are the official names of this protein?
TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1.
Protein: KRE28_YEAS2
Sequence: MDTGSASIKDYETVLTDIEDSIAVSSEEVLNNQELRLKNTLHEITSSILAINEENKFVNPLRNDESLDVEGKEVFVNPKILSAKIKEFNKLMELLKLTYLEQETLDYFFRFTLSSTKPLQLDSEKDPQFVKLNERVNDLKEEISNVQESKIEQIKAEIQETGHNFAEKQDLINELYLEATGDIENCWDSLNELKNLTNKEDKNMMGEKDTILNSSDSDDFVEETYTNWQKLLFLQKQNQRLTKELKEMHEVKNQIIRKGEQSKKEDSGHLMANESELCQSINLLTKFWEKHFLLKGSKTTILNFEIFTQLGKVQFEIKDMQYIIAISLSDLKRPMIKDITILQKAGGNIVTDIEANSKFNNKYRNNTKVQIFEVMDDIISELTNE
What is the function of this protein?
Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3).  Involved in kinetochore-microtubule binding and the spindle assembly checkpoint (By similarity).
What are the official names of this protein?
Spindle pole body component KRE28.
What is the protein family that this protein belongs to?
Belongs to the KRE28 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore. Note=Localizes to the nuclear side of the spindle pole body.
Protein: LFTR_NITHX
Sequence: MMSRETASSEITPELLLRAYACGIFPMAESVDDPTLFWVEPKLRGVIPLESFRISSRLARTVRSDSFAVTVDTAFNAVIDGCAAPQPGRDNTWINRRIRELYIALHELGHCHSVEVWQGDELVGGLYGVRLGRAFFGESMFHIARDASKVALVHLVARLIAGGFVLLDTQFVTDHLRGFGAIEIPRRRYRALLDAALEGRADFAALPLDQPVPGTDALKIIADRA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYB83_ARATH
Sequence: MMMRKPDITTIRDKGKPNHACGGNNNKPKLRKGLWSPDEDEKLIRYMLTNGQGCWSDIARNAGLLRCGKSCRLRWINYLRPDLKRGSFSPQEEDLIFHLHSILGNRWSQIATRLPGRTDNEIKNFWNSTLKKRLKNNSNNNTSSGSSPNNSNSNSLDPRDQHVDMGGNSTSLMDDYHHDENMMTVGNTMRMDSSSPFNVGPMVNSVGLNQLYDPLMISVPDNGYHQMGNTVNVFSVNGLGDYGNTILDPISKRVSVEGDDWFIPPSENTNVIACSTSNNLNLQALDPCFNSKNLCHSESFKVGNVLGIENGSWEIENPKIGDWDLDGLIDNNSSFPFLDFQVD
What is the function of this protein?
Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis.  Is directly activated by NAC012/SND1 and its close homologs, including NAC043/NST1, NAC066/NST2, NAC101/VND6 and NAC030/VND7.  Is required for functional expression of a number of secondary wall-associated transcription factors and secondary wall biosynthetic genes involved in cellulose, xylan and lignin synthesis.  Functions redundantly with MYB46 in the transcriptional regulatory cascade leading to secondary wall formation in fibers and vessels (PubMed:19808805).  Transcription activator that binds to the DNA consensus sequence 5'-ACC[AT]A[AC][TC]-3', designated as the secondary wall MYB-responsive element (SMRE).  Regulates directly numerous transcription factors and a number of genes involved in secondary wall biosynthesis that contain SMRE elements in their promoters (PubMed:22197883).
What are the official names of this protein?
Transcription factor MYB83, Myb-related protein 83, AtMYB83.
What are the subcellular locations of this protein?
Nucleus.
Protein: PROA_CLOB8
Sequence: MSELIIKGQNAKNASYDLGIASTKQKDDALMIMAEELIKAKGDIISANKIDLDAAVLKGTSKAMLDRLALTDERIESMAAGLKDVIKLQDPIGEVISMWQRPNGLQIGQKRVPLGVIGIIYEARPNVTCDAAGLCIKTGNAVILRGGSEAINSNKAIVKALTKGIERSGLPKASVQLVEDTSREVATEMMRLNEFIDVLIPRGGAGLIQAVLKNATVPVIETGTGNCHIYVDKDCDFEMAKNIVINAKASRPSVCNAAEKLLINEKIVEDFLPIVVKALRENGVAVKGDEVSQSIINDIEKAAEEDWGKEYLDYIIAVKVVKDVDEAISHINKYGTGHSEAIITESYKNSQKFLQRVDAAAVYVNASTRFTDGSEFGFGAEIGISTQKLHARGPMGLKELTTIKYIIYGNGQIR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_VARPS
Sequence: MSNVHLVDHPLVQHKLTLMRRKDASTNSFRRLLNEISMLMAYEVTRDMPMQDIEVETPLETMQAKVIDGKKLVLVSILRAGTGILDGMLTVVPGARVGHIGLYRDPKTLTAVEYYFKMPGEMENRDVIVVDPMLATGNSAVAAVERLKELNPKSIKFVCLLTCPEGLATMQKAHPDVPVYTAAIDRELNSHGYILPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ADAP1_HUMAN
Sequence: MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP
What is the function of this protein?
GTPase-activating protein for the ADP ribosylation factor family (Probable).  Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
What are the official names of this protein?
Arf-GAP with dual PH domain-containing protein 1, Centaurin-alpha-1, Cnt-a1, Putative MAPK-activating protein PM25.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
Protein: GLPK_XANCP
Sequence: MEKKYVLAIDQGTTSSRAMLFDRQGKVAGVAQREFGQIFPQPGWVEHNPREIMTSVYTTITELLNNAQIDAREISGIGITNQRETAVVWDKATGQPIYNAIVWQSRQTKDICTQLKEAGHEQMVRDKTGLLIDAYFSGTKVKWILDHVDGARERARKGELAFGTIDSWLIWNLTGGKVHVTDYTNASRTMMYNIHTLEWDAELLEMLDVPAQMLPEVRSSSEVYGMTQTQYFYGEQVPIAGIAGDQQAALFGQACFEPGMAKNTYGTGCFMLMNTGDKAVASKAGLLTTIAWGIDGKVEYALEGAIFVAGSVVQWLRDGLRMFGKASDSQAYAERAGDNDGVYFVPAFVGLGAPYWRSDIRGAVFGLTRGTSKEHFVRAAVESMAYQTRDVLTAMQSDSGIELKELRADGGAIANDFMAQFQSDILNVPVLRPEVAETTALGAAYLAGLATGFWSSREEIAKQWAVDRRFEPNMPEERREQLYAGWQQAVEATMGFRIS
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: BFSP1_BOVIN
Sequence: MYRRSYVFQTRKEQYERAEEAPRAAEPDRLAEARAAAPNLAALQGLGERVAAHVQRARALEQRHAVLRRQLDAFQRLDELAGPEDALARHVEGNRQRARDLAAERTRLERQGAEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLRNLRLQIEAQFLQDDISAAKDRYKKNLLEIQTYVTILQQIIQTTPQAAAITSGMREEKLLTEREAAALQCQLEDGREMICLLQAQRTELQAQTAALEQAIRDAHECYDDEIQLYNEQIDTLRKEIEEAERSLERSSYDCRQLVVVQQTLRNELDRYHRIIENEGNRLSSAFIETPITLYTASHGASLSPRHGGKDLTRAVQDITAAKPRLKGLPKNLPRKKEMVAKDRADEILEETLLRGPEDMKPGRVVIKEEGESKLEPGDEEASPPTQEGAPEDVPDGGKISKAFEKLGKMIKEKVKGPKEPEPPADLYTKGRYVMVSGDGSFVDPGFCVFSVPAKGGVVVSKGDDSVPPDSGVEPSPQQPEPPLEEGQGPPQEKEDGLKEEGGPPEGKGEPPEGKGDSVKEEGGPPEGKGDGVKEEGGPPEGKGDGVKEEGGPPEGKGDGVKKEGEPPEGKGEGLKEEEGPLQKKEDGRPPTPHPADKGDEKNAKELKGLQGKQDDQKEEGARGPCPMVAPGPEGPSTPRSQGPQVILGGSEGHGARSGSRLARSPPRKLAYEKVEVMESIEKFSTESIQTYEETAVIVETMIEKTKANKKKLGEKGSSSA
What is the function of this protein?
Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).  Involved in altering the calcium regulation of MIP water permeability (By similarity).
What are the official names of this protein?
Filensin, Beaded filament structural protein 1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein: PACA_PIG
Sequence: MTMCSGARLALLVYGIIMHSSVYCSPAAAGLRFPGIRPEDEAYDEDGNPLQDFYDSDPPGVGGPASTLRDAYALYYPAEERDVAHGILNKAYRKVLDQLSARKYLQTLMAKSVGGNLDGGAEDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
What is the function of this protein?
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity).  Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity).  In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity).  Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide, PACAP.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.