PharMolix/UniProtQA huggingface dataset:
Protein: NCKP1_XENLA
Sequence: MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFLDITVNFDLTKNYLDLIVTYTTLMIMLSRIEERKAIIGLYNYSHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSAEQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDTMEKWIILGFILCHGILNTDATSLNLWKLALQSSSCICLYRDEVLHFHKAAEDLFVNIRGYNKRINDIRECKENAVSHAGATHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNIPKKIADDFMDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLTDHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSISFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYAPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQVTQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRALSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVEVLTQMRTSFDKPEQMAAFFKRLTSVDSVLKRMTIIGVILSFRSLAQEALKDVLSYHIPFLVSSVEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSETISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSS
What is the function of this protein?
Part of the WAVE complex that regulates lamellipodia formation.  The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.  Actin remodeling activity is regulated by RAC1 (By similarity).  Plays a role in neural tube closure.
What are the official names of this protein?
Nck-associated protein 1, NAP 1.
What is the protein family that this protein belongs to?
Belongs to the HEM-1/HEM-2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side. Note=At the interface between the lamellipodial actin meshwork and the membrane.
Protein: KATG_NITWN
Sequence: MDAKTNDGKAGQCPFTSGRGHKNRDWWPEQLDVQVLHQKSNLSNPMGRDFDYASAFASLDLNAVIADLKALMTDSQDWWPADFGHYGGLMVRMAWHSAGTYRITDGRGGAGGGQQRFAPLNSWPDNVLLDRARRLLWPIKQKYGRKISWADLYVLAGNAALESMGFKPLGFAGGRVDEWEPQELFWGPEGAWLGDERYSGERELAEPLAAVQMGLIYVNPEGPNGQPDPLAAAKDIRETFLRMAMNDEETVALIAGGHTFGKTHGAGDASLVGPVPDSAPIEDQGLGWKGRFGTGKGADAIGSGLEVTWTQTPTKWDNNFFDTLFGFEWELTKSPAGAHQWRAKDAPAITPDPFDESKKHVPTMLTTDLSLRFDPIYGEISKRFHENPDQFADAFARAWFKLTHRDMGPRDRYLGPLVPKEVMIWQDPIPAVDHELVDDNDIADLKAKILASGCTVAQLVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPIQLKAVLAKLEEIQAEFNDAQTGGKKVSLADLIVLGGSAAVEKAARDAGIDLKVPFTPGRMDASLDQTDVESFAPLEPRADGFRNYISDRHQFMAPEEALVDRAQLLNLTGPEMTVLVGGLRVLGANAADSRHGVFTTRPGKLTNDFFVNLLTMDTEWQPVAGQDGVYESRDRKTGTLKWTGTRVDLIFGSHSQLRAFAEVYACADSGEKFANDFAAAWAKVMNADRFDLKA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: SYM_BURO1
Sequence: MSASDLTSVQAAAPQGSRQILVTSALPYANGQIHIGHLVEYIQTDIWVRTLRMHGHEVYYIGADDTHGTPIMLRAEKEGLTPKQLIDRVWTEHKRDFDSFGVSFDNFYTTDSEENRVLSENIYLALQEAGLIAEREIEQAYDPVKEMFLPDRFIKGECPKCHAKDQYGDSCEVCGSTYLPTELLNPYSVVSGATPVRKTSKHYFFRLSDPRCESFLREWVSGLAQPEATNKMREWLGDAGESKLADWDISRDAPYFGFEIPGAPGKYFYVWLDAPVGYYASFKNLCERNGIDFDAWIRPGSKAEQYHFIGKDILYFHTLFWPAMLEFSGHRTPTNVFAHGFLTVDGAKMSKSRGTFITAQSYIDTGLNPEWLRYYFAAKLNATMEDIDLNLDDFQARVNSDLVGKYVNIASRAAGFLIKRFDGRVQDSAMNHPLVAKLRDAIPQIAASYEAREYGRALRHTMELADEVNAYVDGAKPWDLAKDPANAVALHETCSVSLEAFRLLSLALKPVMPRVAVAVEAFFGIAPLAWADAAKPLSSAQPIKAYQHLMTRVDAKQIEALLAANRDSLQAEAAGAAAAGANAAKDAKSNAKASAKPAAVNGADDAPISIDDFAKIDLRIAKIVACQAVEGSDKLLQLTLDVGEEKTRNVFSGIKSAYQPEQLVGKLTVMVANLAPRKMKFGLSEGMVLAASATDEKAEPGLYILEPHSGAKPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
Protein: LIPA_BACAH
Sequence: MTKQTEYKRKPEWLKIKLNTNENYTGLKKMMRSKNLHTVCEEAKCPNIHECWAVRKTATFMILGAVCTRACRFCAVKTGLPTELDLQEPERVADSVVQMGLKHVVITAVARDDLKDGGAAVFAETVRAVRRKNPFTSIEVLPSDMGGVEENLKMLMDAKPDILNHNIETVRRLSDRVRARAKYDRSLEFLRRAKEMQPDIPTKSSIMVGLGETREDLIEAMDDLRANNVDILTLGQYLQPSKKHLPVLKYYPPAEFAELKEIALSKGFSHCEAGPLVRSSYHADEQVRSAKEKTAEAK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_PSEAB
Sequence: MRVILLGAPGAGKGTQARFITEKFGIPQISTGDMLRAAVKAGSPLGQQVKGVMDSGGLVSDDIIIALIKERITEADCAKGFLFDGFPRTIPQAEALKDAGVTIDHVVEIAVDDEEIVSRIAGRRVHPASGRVYHTEHNPPKVAGKDDVTGEELIQREDDKEETVRHRLSVYHSQTKPLVDFYQKLSAAEGTPKYHSIAGVGSVEQITAKVLSALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPA_ECO57
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFSRQFQHGDGQSFNAEDFDDIFSSIFGQHARQSRQRPAARGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGAKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PPAX_BACC1
Sequence: MKINTVLFDLDGTLINTNELIISSFLHTLHTYYPNQYKREDVLPFIGPSLHDTFSKIDESKVEELITSYRQFNHDHHDELVEEYETVYETVQELKKQGYKVGIVTTKARQTVEMGLKFSKLDEFFDVVVTIDDVEHVKPHPEPLQKALQLLDAKPEEALMVGDNHHDIVGGQNAGTKTAAVSWTLKGRAYLEAYKPDFMLDKMSDLLPILSDMNRS
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: RS9_SHEWM
Sequence: MAATQYYGTGRRKTSTARVFAKVGTGNIVVNQLPLDQYFGRETSRMVVRQPLELVEMTDKLDIFVTVKGGGNTGQAGAIRHGITRALMELDESLRPSLRAAGFVTRDARKVERKKVGLRKARRKPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: YMDB_SALTI
Sequence: MTSRLQVIQGDITQLSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRNCLLLAEANHFRSIAFPAISTGVYGYPRAQAAEVAVRTVSDFITRYALPEQVYFVCYDEETARLYARLLTQQGDDPA
What is the function of this protein?
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate.  Down-regulates ribonuclease 3 (RNase III) activity.  Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
What are the official names of this protein?
O-acetyl-ADP-ribose deacetylase, Regulator of RNase III activity.
What is the protein family that this protein belongs to?
Belongs to the YmdB family.
Protein: PA_I77AB
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPIRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDDCKDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: EX7L_LISMF
Sequence: MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFHKAVQKIGFVPEDGMNVLITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQLEKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIHRRMPSVEVIVYPTIVQGEKAAQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETDFALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQHLILNGPKHQLEQQMERTDYFSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQKEQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSLLKRGFGVTYKENMLVKSVQELEVGDNIQVKMQGGQIEALITAKEEDISGN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_CALS4
Sequence: MTLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAFRLGVGFVPVRKPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIVDDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRKKLDGYDIISLIKF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIZ_XENLA
Sequence: MAEGNSDYDHRAMKLQRNLRHCEGKRLELERELFQHSSSDAHICHLKYMKLKNSLKEVCERGKKAHLRNQAFLQEFDLIEARLFGLISNANALQKKKMQLKSHPPEMNKGPNMSRSTYHPATIFMGRQMSASSSIEHCLTQRKSPQPTKSFSISDPHSVRQAAMNRNVTDSCVVPANSDIQCLNKPDKIDGNTSFQLSQKMPVTSVASSEDGRTHRAQIDKSQSGRKHLVESKQSAQLSTQILERLSPENRARDLQNDSPGNMVEKSLMYERLVPNEESFTHANPSGASPDACDYINNQTSDKHSARENLSETIESHLIPEEEDKQCLDSSSDLTVSISESEDDSYPPCEVNRIEVNQNDEKNLYTALPKQETVILKNYEQSSVIQPLQTSEVNSCDESSSASTISQSNLSDEGFFHLLQSIERMVLLREQGGMELYQRAGINQKQLLRLISVCNRMGALRVEDLEACCALVLCKTQELLKSTFVGYSHEATAGIHNTDESKERFLSRKCQERLLGHIAFLNKHHILNEKVLPECFTSVMMLSDGQNSCKSVENVENSTEDGNVPQVSSTMKDDPLTIKPRQIVQELYKTTGSSHQEFETQVHPGVVLQSANISVESNTQAEEENDEDEISDLSEIYIPGLTVEEGNATTKASKKQISETSFSSSEKSPISRKEDKNIQPNYMKSNNMSTGNKFSKVVTTVKSKAFWGESEDSSSEIEAMLRPKTESVDDFDDFFD
What is the function of this protein?
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation.  Required for stabilizing the expanded pericentriolar material around the centriole.
What are the official names of this protein?
Centrosomal protein kizuna, Polo-like kinase 1 substrate 1.
What is the protein family that this protein belongs to?
Belongs to the kizuna family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Protein: REGX3_MYCTU
Sequence: MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRAGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG
What is the function of this protein?
Member of the two-component regulatory system SenX3/RegX3 involved in stress response (PubMed:12777483, PubMed:21698211, PubMed:35980355).  The system is involved in phosphate starvation response (PubMed:28698272).  Plays a role in modulating expression of aerobic response and in the regulation of response to hypoxia (PubMed:21698211, PubMed:35980355).  Involved in virulence (PubMed:12777483).  Regulates dozens of genes, directly or indirectly (PubMed:12777483, PubMed:35980355).  Is directly involved in the regulation of the expression of gltA, cydAB and ald (PubMed:21698211).  Binds to the upstream regions of the hypoxia-associated genes Rv3334, whiB7, Rv0195, Rv0196 and Rv1960c (PubMed:35980355).
What are the official names of this protein?
Sensory transduction protein RegX3.
Protein: GG_HHV2B
Sequence: MHAIAPRLLLLFVLSGLPGTRGGSGVPGPINPPNNDVVFPGGSPVAQYCYAYPRLDDPGPLGSADAGRQDLPRRVVRHEPLGRSFLTGGLVLLAPPVRGFGAPNATYAAHVTYYRLTRACRQPILLRQYGGCRGGEPPSPKTCGSYTYTYQGGGPPTRYALVNASLLVPIWDRAAETFEYQIELGGELHVGLLWVEVGGEGPGPTAPPQAARAEGGPCVPPVPAGRPWRSVPPVWYSAPNPGFRGLRFRERCLPPQTPAAPSDLPRVAFAPQSLLVGITGRTFIRMARPTEDGVLPPHWAPGALDDGPYAPFPPRPRFRRALRTDPEGVDPDVRAPRTGRRLMALTEDASSDSPTSAPEKTPLPVSATAMAPSVDPSAEPTAPATTTPPDEMATQAATVAVTPEETAVASPPATASVESSPPPAAAATPGAGHTNTSSASAAKTPPTTPAPTTPPPTSTHATPRPTTPGPQTTPPGPATPGPVGASAAPTADSPLTALPPATAPGPSAANVSVAATTATPGTRGTARTPPTDPKTHPHGPADAPPGSPAPPPPEHRGGPEEFEGAGDGEPPEDDDSATGLAFRTPNPNKPPPARPGPIRPTLPPGILGPLAPNTPRPPAQAPAKDMPSGPTPQHIPLFWFLTASPALDILFIISTTIHTAAFVCLVALAAQLWRGRAGRRRYAHPSVRYVCLPPERD
What is the function of this protein?
Chemokine-binding protein that inhibits neutrophils' chemotaxis.
What are the official names of this protein?
Envelope glycoprotein G, gG, gG-2.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein G family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: GLPB_ECOL5
Sequence: MRFDTVIMGGGLAGLLCGLQLQKHGLRCAIVTRGQSALHFSSGSLDLLSHLPDGQPVTEIHSGLESLRQQAPAHPYTLLGPQRVLDLACQAQALIAESGAQLQGSVELAHQRITPLGTLRSTWLSSPEVPVWPLPAKKICVVGISGLMDFQAHLAAASLRELDLKVETAEIELPELDVLRNNATEFRAVNIARFLDNEENWPLLLDALIPVANTCEMILMPACFGLANDKLWHWLNEKLPCSLMLLPTLPPSVLGIRLQNQLQRQFVRQGGVWMPGDEVKKVTCKNGVVNEIWTRNHADIPLRPRFAVLASGSFFSGGLVAERDGIREPILGLDVLQTATRGEWYKGDFFAPQPWQQFGVTTDEALRPSQAGQTIENLFAIGSVLGGFDPIAQGCGGGVCAVSALHAAQQIAQRAGGQQ
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: MNMG_SHIB3
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGGNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP6B7_HELAM
Sequence: MWVLYLPAVLSVLIVTLYLYFTRTFNYWKKRNVRGPEPTVFFGNLKDSTLRKKNIGIVMEEIYNQFPYEKVVGMYRMTTPCLLVRDFHVIKHIMIKDFEAFRDRGVEFSKEGLGQNLFHADGETWRALRNRFTPIFTSGKLKNMFYLMHEGADNFIDHVSKECEKKQEFEVHSLLQTYTMSTISSCAFGVSYNSISDKVQTLEIVDKIISEPSYAIELDYMYPKLLAKLNLSIIPTPVQHFFKSLVDNIISQRNGKPAGRNDFMDLILELRQMGEVTSNKYLDGVTSLEITDEVICAQAFVFYVAGYETSATTMSYLIYQLSLNQDVQNKLIAEVDEAIKASDGKVTYDTVKEMKYLNKVFDETLRMYSIVEPLQRKATRDYQIPGTDVVIEKDTMVLISPRGIHYDPKYYDNPKQFNPDRFDAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKILSKFRIEPSKNTDRNLQVEPRRVTIGPKGGIRVNIVPRKIVS
What are the official names of this protein?
Cytochrome P450 6B7, CYPVIB7.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CP46A_HUMAN
Sequence: MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
What is the function of this protein?
P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain.  Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681).  By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity).  Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002).  Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465).  May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828).
What are the official names of this protein?
Cholesterol 24-hydroxylase, CH24H, Cholesterol 24-monooxygenase, Cholesterol 24S-hydroxylase, Cytochrome P450 46A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Postsynapse. Presynapse. Cell projection, dendrite.
Protein: TEAN2_DANRE
Sequence: MDKFVVRLPKDDMMKQESKHERNYKQATLESLRRVVVIEDIERYKSILELPGQPKENMIEALKELDKKVPSREVLKSTRIGHTVNNLRKHSDDPEIKSLAKEVYKHWRTFIEEHANKPSIEVRCDKQTESLRSNAKKLLSEAIEMKVDHELVENIEREVFHQSSRLVSGAYRRTVRALVFALKHKPELRVQVKDGKLPVNVFVKSYKKKS
What are the official names of this protein?
Transcription elongation factor A N-terminal and central domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TCEANC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NFU1_DROER
Sequence: MSKFLSQAALNTLRNTRLGSRQLVRSFAGIASTRNHREPAHQEPGCGQALGRGLLQMRLPVAGRRSMFIQTQDTPNPDSLKFLPGVDVLGKGNTYDFPNGTTAHSSPLAKLLFRVEGVKGVFFGADFVTISKQEGAEWSLIKPEVFAVIMDFFASGLPVLHDAQPNADTEILEDDDETVMMIKELLDTRIRPTVQEDGGDIVFMGYEAGVVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVESVEQVFDEADRMIDSEFERFEKNLKTLKQQEPSGAGPH
What is the function of this protein?
Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
What are the official names of this protein?
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y445_STAAR
Sequence: MEYIKKIALYMSVLLLIIFIGGCGNMKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPIKNLEDLYDKEGYRDGEFEKGDKGMWVLYSSIVSEFKGESLKSRGMILKLDRNKRTAKGSYIIRELKEDKNHDVQKNEKKYPVKLVNNKIIPTEDVKNEDLKREIENFKLFSQYGEFKSLNTDRITNISYNPNAPNYSAEYKINDDDNNIKQLKNRFNIKSNKNPKLLFKGAGNIKGSSVGYKEIQIIFNRNKEESVSCIDSIEFKPSEGDYNE
What are the official names of this protein?
Uncharacterized lipoprotein SAR0445.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: REV_HV2RO
Sequence: MNERADEEGLQRKLRLIRLLHQTNPYPQGPGTASQRRNRRRRWKQRWRQILALADSIYTFPDPPADSPLDQTIQHLQGLTIQELPDPPTHLPESQRLAET
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: GCH41_BURL3
Sequence: MEKALHRISSMNAPLPDISLTDAAPGGRPLEWVGMQGIDLPVAVAEPGCRRDVHARADVQVDLPAPHVKGIHMSRLYRLLDGLGDGTALSPAGLQHVLHAMVDSHRDCDTRSARLRLRFDLLARRAALVTDGLAGWKAYPVRIDATLSGARFELRAQVTVVYSSTCPCSAALSRHWVEQAFLAAFGHDDRVEPAAVAAWLKRHATAATPHSQRSEAVVSVALPADGATLGLIDLIDRIEHALGTPVQTAVKRADEQAFAVLNGGNLMFVEDAARRVQAALDGHHANPRVHVRHLESLHPHDAVAWAAPVREGADAC
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2 1.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RK32_LIRTU
Sequence: MAVPKKRTSMSKKRIRRNIWKKKGYWAAVKALSLAKSISTGHSKSFFVRQTSNKALE
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.