PharMolix/UniProtQA huggingface dataset:
Protein: CASP2_SOYBN
Sequence: MSTTIDVPESSNVAKGKAVLVAPPRPGGWKKGVAIMDFILRLGAIAAALGAAATMGTSDQTLPFFTQFLQFEASYDSFTSFQFFVITMALVGGYLVLSLPFSFVAIIRPHAAGPRLFLIILDTVFLTLTTASGASAAAIVYLAHNGNQDSNWLAICNQFGDFCAQTSSAVVSSFVAVVVLVLLVVLSALALGKR
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 2, GmCASP2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: MEB1_ARATH
Sequence: MDPTMNPTPTPSSAGNSVCTDELTNLPPEDSPLDSEKDDSVDFSQEQGSESNEAIDTENGSRSVDKNQYSETEVVVRAKDLQTEPDSLDDDVEIVIKNQHKYYIYCPCCGEDITKTVKLVKISDPKHTKDHDKAVDSDTENGSKSKDKNTKVPSWFSDFIQPLFSSEDRGKKGVVDSELLGTYEDLGIIGEEPSIDVSNEKDRPSFPKWYLDVFAWLFLCIIIALSVLSTSPPPFIQPHLQLPSMPTLRMPSASVLLLLPTSAVLLLFIISMRSRFTPRYHKEKGEVVPKSTDSKSHDDQAANTDQDFDKKTDNKRNRLTPIYPSSLEKPSKQTVNKETQNHDKEAADPDQDVDKETENQKSHLTPIYPSPLEQPSKQIINKETQTEPMLPPNAQSEIPNSVEPRKGGNKVEILKSIVYGGLTESITSLCTVTSAAASGASTLNVLALGVANLSSGLLLTVHSLQELINEKPRKQTNTDDSPEEGEGEEDRYEEVLGRREYSRIHRVIAISSFVIFGLIPPLVYGFSFRKKMEKRQEYKVLAVYAVSLLCIVLLSIAKAYVSKKRDYVKTLFRYTTTATTASGFSQFVGYLVSQWLEKSGFYDDSPETQRV
What is the function of this protein?
May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity.  Not essential for the accumulation of ER body components, including PYK10.
What are the official names of this protein?
Membrane protein of ER body 1.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
Protein: GCST_LEPIC
Sequence: MSQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGNPKSILLFLESITCNSVASLSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASNYEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIFSKFLKRDLDSIQYYRFMLLPYQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAKYPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPRENFRVLDSQGNEIGKTTSGTFSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITMKPFIPGSIRKN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MINC_CLOTE
Sequence: MLDNNIIIKGNRDGLNAVINMNNFRDFDDMLESLMEKLSKGRLFYKGCTLKIITELKYINEREFRRLKDVLFDEFLIKDCIFEDSEEKVNKPFSGIYEGKTKFIRRTVRSGQVIRYPGNLVILGDVNSGSEIYAGGNVIVLGSLRGYVHAGVRGNRKAVVAAYFMQPQMLQVGDVATRAPEDNVKPQYPEIAKVRGDTIVVEPYLPNKFI
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: SYE_MALP2
Sequence: MNKNKIIRTRYAPSPTGLFHIGGARTALFNYLFAKKNNGDFIVRIEDTDIDRNVENGIESQLLNLKWLKIFPDESPLNPGNYGPYIQTERLPIYKEKAEQLLKEKKAYRCFCTPEQLEKNRKKALKDGKTPKYNRTCLSLSEDQISEKIKNNIPFSLRFKITDNTEIKWNDIVRGEMCVPTSALTDPVILKSNGIPTYNFAVVIDDNDMLISHIIRGEEHLSNTPYQIAINEALDINKNIVFGHLSVIIDETGKKLSKRNMELKQFIEDYKNMGFSPEAIVNFMYLLGLSSSDNKEIFSLAEAVKNFDIKKVSKSPTTFDFKKMEWISSEHFKMMSDSAFISFAKPFITIDLGFLKGNENDVILLFKNQIAYAKQINDLIDETFFSPETFAAVCEKFPFLKQADTKELIKVFIKQLQELPNWNISEIATVIDAVKKQTGKSGKELFMPIRVYSSHNSHGPELAKVIFILGKDKVIKNAKSFLDNKGA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERF3_KLULA
Sequence: MSDQQNQDQGQGQGYNQYNQYGQYNQYYNQQGYQGYNGQQGAPQGYQAYQAYGQQPQGAYQGYNPQQAQGYQPYQGYNAQQQGYNAQQGGHNNNYNKNYNNKNSYNNYNKQGYQGAQGYNAQQPTGYAAPAQSSSQGMTLKDFQNQQGSTNAAKPKPKLKLASSSGIKLVGAKKPVAPKTEKTDESKEATKTTDDNEEAQSELPKIDDLKISEAEKPKTKENTPSADDTSSEKTTSAKADTSTGGANSVDALIKEQEDEVDEEVVKDMFGGKDHVSIIFMGHVDAGKSTMGGNLLYLTGSVDKRTVEKYEREAKEAGRQGWYLSWVMDTNKEERNDGKTIEVGRAYFETEKRRYTILDAPGHKMYVSEMIGGASQADIGILVISARKGEYETGFEKGGQTREHALLAKTQGVNKMIVVINKMDDPTVGWDKERYDHCVGNLTNFLKAVGYNVKEDVIFMPVSGYTGAGLKERVDPKDCPWYTGPSLLEYLDNMKTTDRHINAPFMLPIASKMKDMGTVVEGKIESGHIRKGNQTLLMPNRTSVEILTIYNETESEVDMAVCGEQVRLRIKGVEEEEISAGFVLTSPKNPVKNVTRFVAQIAIVELKSIMSAGFSCVMHIHTAIEEVTVTRLLHKLEKGSNRKSKKPPAFAKKGMKIIAVIETNEPVCVETYDDYPQLGRFTLRDQGTTIAIGKIVKILEN
What is the function of this protein?
Involved in translation termination.  Stimulates the activity of ERF1.  Binds guanine nucleotides.
What are the official names of this protein?
Eukaryotic peptide chain release factor GTP-binding subunit, ERF-3, ERF3, ERF2, Polypeptide release factor 3, Translation release factor 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_BACCR
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIFHDIEVYGIYHGYAGLISGHIEKLELGSVGDIIPRGGTKLYTARCLEFKDPEVRLKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEQGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLADGAETILIPEEEYDMDDVIARLKRGSERGKKHSIIVVAEGVGSAIDIGKHIEEATNFDTRVTVLGHVQRGGSPSAQDRVLASRLGARAVELLIAGKGGRCVGIQDNKLVDHDIIEALAQKHTIDKDMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_ECO55
Sequence: MSRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWAAMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSLLTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMAKFQSIF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: PSB2_SULIM
Sequence: MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLTRIMNVEIKYYEISTGKPISVHAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLITKAIKASIERDITSGDGIDLAIMDKKGNYENKFIPY
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 2, 20S proteasome beta subunit 2, Proteasome core protein PsmB 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_LACPL
Sequence: MQIVEKAPAKINLGLDTLFEHPNGDKEWDMVMTSVDLADYVMLESLHTNRIEVVTDSGFLPNDRRNLAFQAVSVLKRYCHVDRGVRIKIRKAIPVAAGLGGGSSDAAAVLRGLNRMWNLHLDLATLARLGLQVDSDVPYCVYSQTAHVTGKGDVVTPLPKLPPMWIILAKPKVSVSTPNILRQVNYERIDQHPNIEALLAGIQQQDFAEIFANMGNVLEPITAKRYPEILQIKRQLLTFGADAAQMSGTGPTVFGVCRKQSRAQRVYNSLKGFCREVYLVRPVNLNEH
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ACPS_CROS8
Sequence: MAILGLGTDIVEIDRIEAVISRSGDRLAKRVLSANEWAQYQAHQQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPKLRLWDEAERLAARMGVTSVHVTLADERHYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_SYNY3
Sequence: MKFLILNAGSSSQKSCLYELTGDRLPETIPEPLWEAFIDWTVLANQGRLTVETAGQKQVIILETGDRQQGIARMLDTLVTGDDAVLKSLAEIDLVGHRVVHGGTDHAEATLITPEVQQAIADLIPLAPAHNPAHLEGIEAISALLVLGEVPQIAVFDTAFHRTIPTPAAEYPIPQAWTNLGIRRYGFHGTSHKYCAQKTAEILGKPLADLKLITCHIGNGASLTAIKNGVSIDTTMGFTPLEGLMMGARSGSIDPAILLFLQETQGLTPAEINTTLNKKSGLLGVSGLSADLRTILQAKAEGNEQAQLAYVMYIHRFRSCLGQMIASLEGLDTLVFTAGVGENAATVRADVCQAFEFLGLKLDPELNNRSPRDTVISHSDSLVTVLIVHTEEDWAIAQDCWHWWHSQGQRKQS
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1771_AERPE
Sequence: MKIRNPAHAGTFYPATREELVKSIESSFTHPLGPGRLPQRGGGSGEQAIAYIPPHAGYMYSGPIAAHVYYDMSLGRKPDVVVLLGPNHTGLGLAASLWDEGVWRTPLGEVEVDSEAGRLVVEYSGIVAPDDEGHIYEHSLEVQLPFLQYLYGGDFRIVPIVVLHQTLDISIRIARAYHRLREENGVNAVLVATSDLNHYEPYEENKRKDLLLLKAIEEGDPEAVFKTIEAHAISACGPSPIAAAVEAGRLAGVKPRVLAYANSGDVTGEKAWVVGYPAVRV
What are the official names of this protein?
MEMO1 family protein APE_1771.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: PLM_CANLF
Sequence: MAPLHHILVLCVGFLTTATAEAPQEHDPFTYDYQSLRIGGLIIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
What is the function of this protein?
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:12169672).  Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity).  Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534).  Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity).
What are the official names of this protein?
Phospholemman, FXYD domain-containing ion transport regulator 1, Sodium/potassium-transporting ATPase subunit FXYD1.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks.
Protein: SEMG2_PONPY
Sequence: MKSIILFVLSLLLILEKQAAVMGQKGGSKGQSPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDVNDHDRTRESQQYDLNALHKTRKSKQHLGGSQELLNYKQEGRDHDKSKGHFHMIVIHHKGGKAHRGTQNPSQDQGNSPSGRGISSQYSNTEKRLWVHGLSKEQASASGAQKGRTQGRSQSSYVLQTEELVANKQRETQNSHQNKGHYQNVVEVREKHSSKLQTSLRPAYQDRLQHGPKDIFTTQGELLVYDKNQHQTKNLNQDQEHGRKAHKISYQSSHTEERQLNHGEKSVQKDISKGRISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKMSYQSSSTEERHLNCGEKGIQKSVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDIQKGVSKGSISIQTEEKIHGKSQDQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKNTQKDVSQSSISFQTEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADREQDLLSHEQKGRYQQESSAARNIVITEHEVARDDHLTQQYNEDRNPIST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LSRA_ECOLC
Sequence: MQTSDTRALPLLCARSVYKQYSGVNVLKGIDFTLHQGEVHALLGGNGAGKSTLMKIIAGITPADSGTLEIGGNNYARLTPVHAHQLGIYLVPQEPLLFPSLSIKENILFGLAKKQLSMQKMKNLLAALGCQFDLHSLAGSLDVADRQMVEILRGLMRDSRILILDEPTASLTPAETERLFTRLQELLATGVGIVFISHKLPEIRQIADRISVMRDGTIALSGKTSELSTDDIIQAITPVVREKSLSASQKLWLELPGNRPQHAAGTPVLTLENLTGEGFRNVSLTLNAGEILGLAGLVGAGRTELAETLYGLRTLRGGRIMLNGNEINKLSTGERLLRGLVYLPEDRQSSGLNLDASLAWNVCALTHNLRGFWAKTAKDNATLERYRRALNIKFNQPEQAARTLSGGNQQKILIAKCLEASPQVLIVDEPTRGVDVSARNDIYQLLRSIAAQNVAVLLISSDLEEIELMADRVYVMHQGEIAHSALTGRDINVETIMRVAFGDSQRQEASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ABDH_ECOSM
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINVLFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTAPSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDDSTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTLFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: RPIA_FRATT
Sequence: MFFNKKNNQDELKKLAATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKTVVSSSEDSTRKLKALGFDVVDLNYAGEIDLYIDGADECNNHKELIKGGGAALTREKICVAAAKKFICIIDESKKVNTLGNFPLPIEVIPMARSYIARQIVKLGGQPVYREQTITDNGNVILDVYNLKIDNPLKLETELNQITGVVTNGIFALKPADTVIMATKDSNIVVL
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: AHR_RABIT
Sequence: MNGGGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSSADRNGGQDPCRAKFGEGLNLQEGEFLLQALNGFVLVVTVDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTDPGQGADETHGLPQPVYYNPDQLPPENSSFMERCFICRLRCLLDNSSGFLAMNFQGRLKFLHGQNKKGKDGSLLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGQIVLGYTEAELCMRGSGYQFIHAADMLYCAESHIRMIKTGESGLAVFRLLTKDNRWAWVQSNARFIYKNGRPDFIIATQRPLTDEEGREHLLKRNTKLPFMFTTGEAVLYEMTSPFPPIMDPLPIRPKSGTCGKDSATKPTPSKDSVHPSSLLSALMQQDESIYLYPPSSNAPFERNFFTESLNECSNWPENVASVAGGSVLKHEQIGQSQEVSPAFSGDQTVLFPDNKNCDLYNIMKNLGVDFEDIKNMQNEEFFGADFSGEVDFRDIDITDEILTYVQDSLNKSPFGSPGYQPQPATALNSSCMVQERLQLGPPQQPPCRSEQATVEPQQQLCQKMEHMQVNSMFANWSANQPVPFSEPQQDLQPYSVFTDFHTADQAFPYTAAMNTMPYTQNFTPCNQTVAPQHSRCTQLDFAMGNFDSSPYPSTSNLEDFVTCLQVPDRQTHGGNPQSAMVAPQTCYAGAVSMYQCQPGPAHTLMGQMQCEPPVPGPEAFLNKFPNGGMLNETYPADLHDINNTVASTHLPPLHHPSEARPFPDLASGRLL
What is the function of this protein?
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:9022676).  Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation.  Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).  Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.  Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists.  Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands.  Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity.  Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.  Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1.  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).
What are the official names of this protein?
Aryl hydrocarbon receptor, Ah receptor, AhR.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Protein: RNPA_SHEFN
Sequence: MTSYTFSRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNSEQHPRLGLTVAKRFVKRANQRNRIKRVIRDSFRLHQHDIPDIDIVVLVRNGVMEMENAELHKLIEKLWRKLSRRYNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL15_MOUSE
Sequence: MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YXJJ_BACSU
Sequence: MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYLLFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS
What are the official names of this protein?
Uncharacterized protein YxjJ.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FA98B_MOUSE
Sequence: MRGPELGPETSMEGDVLDTLEALGYKGPLLEEQALSKAAEGGLSSPEFSELCIWLGSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLVSGDIKERLTKKDDCLKLLLFLSTELQALQILQKKKHKNSQLDKNSEICQEVQAVCDALGVPKSDTSDIPLLLSQVESKVKDILCRVQKNHVGKPLLKVDLSSEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKAKTDNIARIYQPKRYALSPKTTVTLAHLLAAREDLSKIIRTSSGISREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGRGGWGGGGGGRGGGGGGRGGWGGGGGWGGGGGSGGGWGGSGGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGGGGYRRY
What is the function of this protein?
Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation.
What are the official names of this protein?
Protein FAM98B.
What is the protein family that this protein belongs to?
Belongs to the FAM98 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL30_FRATH
Sequence: MTQAKTFKVTLVKSLIGRKENHIASARGLGLRKINHTVEVLDTPENRGMANKIYYMVKIEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TRMD_PSYA2
Sequence: MYFAVISIFPEMFATIREFGITGRAVAQKQVTIECINPRDYTSDNYRRIDERPYGGGPGMVMMAEPLSQAIEDARLRASQYGCRVDKAHCPVIYMSPQGQTLSESSVVDMTEYDGMIILCGRYEGIDERLLSQYVDMEISLGDYVLTGGELPAMVLMDSVIRRLPNIMGDDKSAEQDSFVDGLLDCPHYTKPHEFAGMAVPEVLLSGHHANIAQWRFRQQVERTQTRRPDLWQAFMPTVEQAKWLKALAKADKK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_BREBN
Sequence: MPKMKTNKAAAKRFKKTGSGQLKRDRAFGSHLFANKSTKAKRHLRKAALVSKGDQKRIEQMLTYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.