PharMolix/UniProtQA huggingface dataset:
Protein: WZYE_ERWT9
Sequence: MTLLQFAGLLLVWLVCGGFILTLTWREFRRVRFNFNVFFSMLFLLTFFFGFPLTCILVFGFDVEVVPAEYLLQALLSAGCFYAIYYVTYKTRLRTRHRAPSRPAFTINRIEAHLSWMIMALVALITVSVFFLHNGFLLFKLQKYSQIFSADVSGVALKRFFYFFIPAMLVVYFLQQNMRSWLLFLVGTVAFGLLTYAIVGGTRANIIIAFALFLFIGIIRGWITLWMLALAGVGAIVAMFWLALKRYNLDVSGSQAFYTFLYLTRDTFSPWENLGLLLQNYDRIDFQGLAPVWRDFYVFIPSWLWHERPSVVLNSANYFTWEVLDNHSGLAISPTLIGSLVVMGGALFIMLGAVMVGLIIKWFDWLYEKGRQEENPYKAAILQSFCFGAVFNMIVLAREGLDAFVSRVVFFCVIFAACVLVAKLLYWLLDSAGLVRARKGPACARSSLKHCFVGNDS
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_GEOUR
Sequence: MEKVWLEAQSNIKKVLTPQTYNTWIKPIRFHTLTDDNLTLEVPSKFIKEWVTEKYLPMIVEAISSLTSVKYQIEFKITEKIPLESKPVDNFTPVIKDNEPSKETNKNIDITANLNPKYTFDSFVCGASNQFAHAASQAVASNPASNYNPLFIYGGVGLGKTHLLIAIGNHIKENNKKAKICYYSSEKFMNEMINCLRYKKMDEFRNKFRKMDILLIDDIQFMAGKEATQEEFFHTFNALYESHKQIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQPPDIETKIAILKKKSDLNSITLPNDVALFLASSATSNVRELEGMLIRLGAYASLTGSEITLNMARDILKDIIVEKTKDITVEMIQKHVAEHFKIKVSELKSDKRLKTFVVPRQIAIFICRELTKSSYPEIGEKFGGKDHSTIIHSVKKIEKQMANDLEIKNIVENLKKELIT
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLCA_LITCL
Sequence: FLGGLMKAFPALICAVTKKC
What is the function of this protein?
Antibacterial activity against Gram-positive bacterium S. aureus (MIC=17 uM) and Gram-negative bacterium E. coli (MIC=4 uM).  Has activity against C. albicans (MIC=14 uM).
What are the official names of this protein?
Ranalexin-1Ca.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PGK_TETTH
Sequence: MLSRKIGIDHILKHIENKRVLMRVDFNVPLKEGKVKDPTRIQGSVPSIKKILEQNPKGLVLMSHLGRPDGNRVEKHSMKPVVPKLEELLGTKVTFLNDCVGKDVEEAVKSSRNGEIILLENLRFHPEEEGKYIDAAGNKVKADSKAVKEFRKSLTSLGDLFVNDAFGTAHRAHSSMVGVDHKIRAAGYLLKRELDYFSKALESPNRPFLVVLGGAKVKDKIQLIESMLDKVDEMIIGGGMAFTFLKKIHNIEIGNSLFDEEGYKIVDQLLEKAKAKNVKIHLPVDFLCGDSLEANANTRSFDLKSGIPAGWIGLDAGPKTMAENAEAVARANTIVWNGPQGRFEVDKFKVGSSDLLKHVATRTSQGATSIIGGGDTVNLVQQEKATQKVSHVSTGGGASLELLEGKVLPGVAYLTDIDQL
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
Protein: L2GL2_MOUSE
Sequence: MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVEFMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRGPPGAAPSATQVTEILPHSSGELLYLGTESGNVFVVQLPGFRTLHDRTICSDEVLQWLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRALSHFLSSQQLENASWQRDGCLIVTCHSDGSHCQWPVSSDTQNPEPLRSSIPYGPFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPSENLIAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVCFEAGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSHKRRPGGPTGEAQAQAVNIKAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAERRTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGSCRAEDYGEHHLAVLTNLGDIQVVSMPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSTKAKKHNRPSNGNGTGLKMTSSGHVRNSKSQSDGDEKKPGPVMEHALLNDAWVLKEIQSTLEGDRRSYGNWHPHRVAVGCRLSNGEAE
What is the function of this protein?
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division.  This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity).
What are the official names of this protein?
LLGL scribble cell polarity complex component 2, Lethal giant larvae-like protein 2, Lethal(2) giant larvae protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat L(2)GL family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells (By similarity).
Protein: BPT_THIDA
Sequence: MHPTEPPFQRIQFYLTAQYDCSYLPGRLARSQVATPTHLIDHHAYGALIRAGFRRSGQFTYRPNCEGCQACVPVRVDVSGFVPNRTQRRCLKRNRGLAARFLPLDFKDEHYALYRAYLGSRHAGGGMDRDGPEQYTQFLLSSNVDSVLVEFRDGDAVVMVAVIDQVDDGLSAVYTFFDPAREQDSLGVYGVLWQIELAKRLDLPYLYLGYWIGESRKMAYKKQYPPLQGLVDGSWQALEA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CY553_DESVM
Sequence: MKRILVVMSICAALAFGVSAAMAADGAALYKSCVGCHGADGSKQAMGVGHAVKGQKADELFKKLKGYADGSYGGEKKAVMTNLVKRYSDEEMKAMADYMSKL
What is the function of this protein?
Natural electron acceptor for a formate dehydrogenase.
What are the official names of this protein?
Cytochrome c-553, Cytochrome c553.
What are the subcellular locations of this protein?
Periplasm.
Protein: PDZ11_HUMAN
Sequence: MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
What is the function of this protein?
Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
What are the official names of this protein?
PDZ domain-containing protein 11, ATPase-interacting PDZ protein, Plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein.
What are the subcellular locations of this protein?
[Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cell junction, adherens junction. Cell membrane.
Protein: ATPL_LEVBA
Sequence: MGAIAAGIAMAGAAIGGGVGDGIVISKMLEGMARQPELSGQLRTNMFIGVGLVEAMPIIAFVVALMVMNK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROK_CUPPJ
Sequence: METGRPNLFFVGLMGAGKTTVGRTVARRLHYPFFDSDHELEAHCGVRIPVIFEHEGEEGFRDREAAMIRELTGRSGIVLATGGGAVLRPENRELLKSRGTVVYLRASPHDLWLRTRHDRNRPLLQTEDPKGKLEALYGARDPLYREVADFIIETGKPSVAQLANMVLMQLEMAGFRIDTAAASDQPANDTHS
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT53_CONLT
Sequence: MRFLPVFIILLLLIPSAPSVDAQPMTKDDVPLSSLHDNAKRALQMFWNKRDCCPAKMFCCQW
What are the official names of this protein?
Conotoxin Lt5.3, LeD33, Lt5c.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYH_ECO27
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQVLLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP2_TRYBB
Sequence: MAEAHKYKKLTPIEHVLTRPEMYIGSLDTTATPMFIYDEQKGHMVWETVKLNHGLLKIVDEILLNASDNISNRSARMTYIRVTITDTGEITIENDGAGIPIVRSREHKLYIPEMVFGHLLTSSNYDDDNQNAVAGRHGYGAKLTNILSLSFSVCCRTNGREFHMSWQDHMRKATAPRVSNVGTKEKNVTRVKFLPDYERFGMKEKKISNDMKRVLYKRIMDLSAMFPNIQITLNGSSFGFKSFKDYATLYSAMTPKGEKPPPPYVYESKSGCVAFIPSVVPGVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTITGQLAQELNKEIGTGRRMSSKTLLTSITKLVDATSTRRDPKHTRTLIVTEGDSAKALAQNSLSSDQKRYTGVFPLRGKLLNVRNKNLKRLRNCKELQELFCALGLELDKDYTDADELRYQRILIMTDQDADGSHIKGLVINAFESLWPSLLVRNPGFISIFSTPIVKARLRDKSVVSFFSMKEFHKWQRSNANTPYTCKYYKGLGTSTTAEGKEYFKDMEKHTMRLLVDRSDHKLLDNVFDSQEVEWRKDWMTKANAFTGEVDIDRSKKMLTVTDFVHKEMVHFALVGNARALAHSVDGLKPSQRKIIWALMRRSGNEAAKVAQLSGYISEASAFHHGETSLQETMIKMAQSFTGGNNVNLLVPEGQFGSRQQLGNDHAAPRYIFTKLSKVARLLFPSEDDPLLDYIVEEGQQVEPNHYVPILPLLLCNGSVGIGFGFSSNIPPFHRLDVSAAVRAMISGERAKSVVRRLVPWAVGFQGEIRRGPEGEFIAVGTYTYCKGGRVHVTELPWTCSVEAFREHISYLATKDIVNRIADYSGANHVDIDVEVAQGAVNTYAECESELGLTQRIHINGTVFSPNGTLSPLESDLTPVLQWHYDRRLDLYKKRRQRNLTLLEQELAREKSTLKFVQHFGAGHIDFANATEATLEKVCSKLGLVRVDDSFDYILRKPITFYTKTSFENLLKKIAETERRIEALKKTTPVQLWLGELDQFDRFFQDHEKKMVEAILKERRQRSPPSDLLPGLQQPRLEVEEAKGGKKFEMRVQVRKYVPPPTKRGAGGRSDGDGGATAAGAAAAVGGRGEKKGPGRAGGVRRMVLDALAKRVTRLLPRLLF
What is the function of this protein?
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.  Topoisomerase II makes double-strand breaks.
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYH_FRATM
Sequence: MSKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEYVTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQTCQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKTAAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLER
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT12_NICSY
Sequence: MPTKNQLIRHGREEKRRTDRTRALDQCPQKQGVCPRVSTRTPKKPNSAPRKIAKVRLSNRHDIFAHIPGEGHNSQEHSMVLIRGGRVKDSPGVKFHCIRGVKDLLGIPDRRRGRSKYGAEKPKSI
What is the function of this protein?
Protein S12 is involved in the translation initiation step.
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYDP_ECO57
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLAPNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: Y1085_METJA
Sequence: MDNMGKDKNILKIRANLIKYIDVDEIEELPKVKVKNVEEFLEAHRVLGKHVICRYKDNLEDIFFFVDNGVIFYIPSDGFKTLEDLIEAKSLGLSAEEYYEYLEFGDINEYKKYKSSGFKSIEEYKKAKDLGFIGGLEELVKEGIAQRLDDKYIIEYLYYGILENREFSNDAELYYFAIEKGFSDFDELKNALKAGFGDANEYKDALNRGFKDAYEYNDALSKGFRDADEYKIAKAIGVNSKKELEEYMELKRICENFGLETFEEGYLLKVLMDLKIDEEITLKELYNKLKEKERLMKIKKDVLNKLANLSSPSWYSTRFTTVDDLEEYLVDSEIVSYLGEYIKEEKIFRRIYPPKPSRRIVIIDAISVLNNMHNLSPNSIENLIKKIKNAGFKNIITVMDTVTYYKIKGKDICRFLANECNIKVSKSKDEAYKLIIEYIKNFGALVISNASFKDYIIKDSKLFYKDIKEYIIPFIVENGEINLDIELLRKLYTEVVTKRIEKIKSNVVS
What are the official names of this protein?
Uncharacterized protein MJ1085.
Protein: SYDND_JANSC
Sequence: MHAYRSHSCAALTAANVGETIRLSGWVHRRRDHGGVIFIDLRDHFGITQILCDPDSPVFAEVEKLRAEFCIRIDGEVKARAPELVNEKLPTGEIEVYIRDMEVLGAAGELPLQVFGDQEYPEETRLKYRYLDLRREKMQTNMMLRSDVVASIRKRMWDKQFREYQTPIITASSPEGARDFLVPSRQHPGKFYALPQAPQQFKQLLMVSGFDKYFQIAPCFRDEDPRADRSPTDFYQLDLEMSFVEQQDVFDTIEPVLRGVFEEFGDGATVDQQWPLISYADAALWYGTDKPDLRNPIKMQIVSEHFAGSGFAIFAKLLEQEGTQVRAIPAPKGGSRKFCDRMNKFAQEQGLPGMGYIFWRDQGEGMEAAGPLAKNIGPERTEAIRQQLDLGVGDAAFFLAGKPSQFEAVAGRARSVIGDELGLTEQNRFAFAWIVDFPMFEADEETGKIDFSHNPFSMPQGGLAALDGDPLSVLGYQYDLACNGYELVSGAIRNHQPEIMFKAFEVAGYGADEVRKRFGGMVNAFQYGAPPHGGCAAGIDRIVMLLADTANIREVILFPMNQRAEDLMMNAPSEPMPDQLMELGLRVLPQD
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDJ_ECOL5
Sequence: MFKPHVTVACVVHAEGKFLVVEETINGKALWNQPAGHLEADETLVEAAARELWEETGISAQPQHFIRMHQWIAPDKTPFLRFLFAIELEQICPTQPHDSDIDCCRWVSAEEILQASNLRSPLVAESIRCYQSGQRYPLEMIGDFNWPFTKGVI
What are the official names of this protein?
Phosphatase NudJ.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudJ subfamily.
Protein: CHSB_IPOPU
Sequence: MSTTVTVLTDTWSRRAKRLEGDAKILAIGTATPASWVDQTTYPDFYFRITNSQHLLEHKEKFRRICNKSKIRKRHLVLTEELLKKNPNLCTYNETSLNTRQDILVSEVPKLGKEAAMKAIKEWGRPISEITHLVFCTTSGVDMPGADFQLTKLLGLNSSVKRLMMYQQGCNAGAAMLRLAKDLAESNKGGRVLVVCAEITINIFRGPSLEQDDNLLAQCLFGDGAAAMIVAADPRPGLETPLFELVSSAQTIVPNTDSHLKLHLREMGLTFHCSKAVPSVLAENVEDCLVKAFEPYGISDWNSIFWVFHPGGNAIVDRVEERLGLGPEKLRASRDVLSEYGNLTSACVLFILDEMRKKSKKDEQMTTGEGLEWGVVFGFGPGLTIDTIIIRSVPIN
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase B, Naringenin-chalcone synthase B, CHS-B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: HPM5_HYPSB
Sequence: MSASNGEIVQRIESLLASAKKLQGDDQYGRFGLLKEIDLLYQDVEPPINTFFKQWTSLTFFSCIDIAIKLGLFEHMKGRESITAKELGALVNVDDDVIARVMRVLVASRFVASKGEDAYAHTHKSLVYVKGEHTAVDSFNLISLLAVSYITIPEYLKTRSADELVDIRKTPYACAYGMEGKTFYEVLSTNPDHLDTFNRSMSEPGPEWGMFPFESLRENVLAEPERPFVVDIGGGKGQALLRIQEETGKVFGTSSQLILQERPDVLEQINQDDIAGITKMPYDFHTKQPVKDAHVYFFSQIIHNYPDHVCQDILKQAAGAMGPSSRLLIVEAVLPAQTDVGGDMGAYLIDFVGLAMGGKERTEKEFATLLGTVGLELVKVWHGKARHHAIVEARLKRA
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690).  The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707).  The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707).  Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707).  The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690).  The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690).  The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690).  The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690).  The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690).  The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690).  The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A.  The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
What are the official names of this protein?
O-methyltransferase hmp5, Hypothemycin biosynthesis cluster protein hpm5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MIX23_MOUSE
Sequence: MAAPSGSVNCEEFAEFQELLKVMRTIDDRIVHELNTTVPTASFAGKIDASQTCKQLYESLMAAHVSRDRVIKNCIAQTSAVVKSLREEREKNLDDLTLLKRLRKEQTKLKWMQSELNVEEVVNDRSWKVFNERCRVHFKPPKNE
What are the official names of this protein?
Protein MIX23, Coiled-coil domain-containing protein 58.
What is the protein family that this protein belongs to?
Belongs to the MIX23 family.
Protein: SYP_ACIET
Sequence: MKASQFFISTLKEAPADAEVVSHQLMMRAGLIKKLGAGIYNYMPMGLRVIRKVEAIVREEMNRAGAVECTMPVVQPAELWQETGRFDKMGPELLRIHDRHGRDFVIQPTSEEVVTDIARQELRSYKQLPKNLYQIQTKFRDERRPRFGLMRGREFIMKDAYSFDRDQAGAKASYQVMAQAYRRIFDRFGLRYRAVAADSGAIGGDLSEEFQVIAATGEDAIVYCPASDYAANMEKAEALAPAGARPAAKQPLTVTPTPGKSTCADVAELLSVPLSTTVKSLVLATDETDAAGEIIRSQVWLLLLRGDHDMNEIKVAKVPGLDAGFRFATVAEIADHFGCKPGYLGPLNLQKPVKLVVDRDVAVMADWICGANQEGHHITGVNWGRDLPEPDMVADLRNVVAGDLSPDGQGELAIERGIEVGHVFYLGTKYSKAMNATFLGEDGKPAFFEMGCYGIGVTRLPAAAIEQNHDERGIIWPDAIAPFTVVICPVGMDRSEAVKAQAESLYADLLAAGVDVILDDRGERPGAMFADWELIGVPHRVTIGDKSLKEGQVEYQHRRDASATKVGVADILAHVKERLAA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARSR1_PSEPK
Sequence: MAVRAFPGGHMREILTPPIVFKCLADDTRARMTLLIAREGELCVCELTHALELSQPKISRHLAQLREAGILMDRRKGQWVYYRLHPEVPQWVDAMLKGVVDANQEWLSPDALRLAEMGERPQSPVACA
What is the function of this protein?
Binds arsenite and regulates the expression of arsenic efflux pumps.  In vitro, also binds antimony and bismuth, but not arsenate.
What are the official names of this protein?
Arsenic resistance transcriptional regulator ArsR1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y925_SYNY3
Sequence: MVALSSNGYFSPDDYLELESRSDVKHEYIDGQIYAMAGTGGIHNIISGNFYMALRSRLQNSGCRVYFADLKVKLKEGRRFYYPDLLVTCDERDAPSQAFVNFPRVIIEVLSESTEGFDRGKKFQDYRTLPSLWAYILVNAQQYLVECFQRTPQDFWLLKSYEGLEAIADIEALNLAIPLAEIYATLNLPALVDEVGMETDLT
What are the official names of this protein?
Uncharacterized protein sll0925.
What is the protein family that this protein belongs to?
To Synechocystis PCC 6803 sll1609 and sll0925.
Protein: PAL_RHIME
Sequence: MSRIDTPAASRMQTIARNPVMIALVMTLALAGCASKKNLPNDAAGLGLGAGAATPGSQQDFTVNVGDRIFFDTDSTSIRADAQATLDRQAQWLAKYPNYGITIEGHADERGTREYNLALGARRAAATRDYLVSRGVPGNRMRTISYGKEKPVAVCDDISCWSQNRRAVTVLGGAGS
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Peptidoglycan-associated lipoprotein, PAL, Outer membrane lipoprotein Omp16 homolog.
What is the protein family that this protein belongs to?
Belongs to the Pal lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PYG1_MASLA
Sequence: MPIPLLSFPLTTQNQRVEGYEVPNEDTPTIYRLTDTSSDTEIDAIIWAAYRQIFSEHLILETYRQPYLESQLRNRAINVRDFIRGLGKSEVYRQEVAQTNSNYRLVDISFKRFLGRATYGKSEQIAWSIVIATQGLHGFIDALVDSEEYRQNFGDDIVPFQRRRFKDRPFNLVNPRYADYWRNRLLEQFLGGQSFYRVVRAGESGKRGVAGAIPSTFLSMAASIAPSGISYQRTADSARTFISTVKLPETTSESKTPPPTVKPATVALPYRYIPGNKTT
What is the function of this protein?
Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
What are the official names of this protein?
Phycobilisome rod-core linker polypeptide CpcG1, L-RC 31.7.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRF_STAEQ
Sequence: MRNLPIIALDFKSADEVHTFLNKFNEPLCVKIGMELFYQTGPALIKSIKKRGHDIFLDLKLHDIPNTVSKAMEGLARLDIDLVNVHAAGGIKMMEEAKKGLRKHNADIKIIAVTQLTSTTERQLHEEQNIQTSIEEAVLNYARLTKKAGLDGVVCSPLEAKMISKELGSDFLKVTPGIRPKGAARNDQQRITTPEEAKTLGSTHIVVGRPITQSEHPIDSYHKIKESWLS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.