PharMolix/UniProtQA huggingface dataset:
Protein: ANK1_HUMAN
Sequence: MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP
What is the function of this protein?
Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
What are the official names of this protein?
Ankyrin-1, ANK-1, Ankyrin-R, Erythrocyte ankyrin.
What are the subcellular locations of this protein?
[Isoform Er1]: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. SUBCELLULAR LOCATION: [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells. SUBCELLULAR LOCATION: [Isoform Mu18]: Sarcoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform Mu19]: Sarcoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform Mu20]: Sarcoplasmic reticulum.
Protein: GEP7_LACTC
Sequence: MLSQYLRKHHLLSRRHQFMRCASQSRSPPRSLLQRQAKRRGEAEAVAPSQLIVTSLKDIFSTFQPSGFTQEDDELEAVKQREDAMQRLENGELRELLLHKFGARRIPSTTETGNSVGDLRIPPRNINQAFHNLTTQERELIEVFQSLGTPSMNWRDVPLVSKQLQFYISFGSYGPREGITFLGSKPEDFIWSKTSRRLLPGQTVRKLPKDATTNTWTCIPSRKANFERMKKGLDPGTRIIAWLGILIVMIASVRDYKQRRDSEATVKVSEFTEQETSEPQAAQQDTAPISKTPKSWYQFWKS
What is the function of this protein?
Involved in respiratory growth and required for cell survival in the absence of prohibitins.
What are the official names of this protein?
Genetic interactor of prohibitin 7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GEP7 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: PYRB_NOSS1
Sequence: MPTSTWNRHHVLSLADFTAAEYDIVLKTAASFQEVLSRRTKKVPALQGQVVANLFFEPSTRTRSSFELAAKRLSADTLNFAASTSSMTKGETILDTAKTYLAMGTDIMVIRHKEAGVPNAIAQEMDRLGVRVSVLNAGDGQHEHPSQGLLDLFTICSLIDPANPRLELLQGKKIAIVGDILHSRVARSNIWSLIASGAQVHLAAPPTLLPKFFAEYIFGEETAPPGQLFIHWQLEPALQEADFVMTLRLQKERMTANLLPSLREYHQLFGITRAKLQLCQPNVKVLHPGPVNRGVEISSDLMDDPEFSLIQSQVTSGVAVRMALLYLIGSGKT
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: PLP2_ORYSI
Sequence: MASASSPEGASSSSPEKVKMVTVLSIDGGGVRGIIPATILAFLEKELQKLDGPDARIADYFDVVAGTSTGGLLTAMLTAPNENNRPLFAADELAKFYIEHSPSIFPQKNWVLSKIAGTLRMVSGPKYDGKYLHSLLREKLGDTRLDKALTNVVIPTFDIANLQPTIFSKFELKYKPLKNALLSDISISTSAAPTFFPAHYFETKDDNGQTREFNLVDGGVAANNPTLCAMSQVSKYIILEDKEDCDFFPVKPTEYGKFMVISIGCGSNHDQKYKAKDAAKWGIFNWLIKGSSAPIIDMFTSASADMVDIHLGVLFSALQCEKNYLRIQYDQLTGSAGSIDDCSKENMDNLVKIGEMLLDKNVSRVDLETGHYVDVAGEGTNRDQLAKFAKQLSDERRRRQNEPSN
What is the function of this protein?
Possesses non-specific lipolytic acyl hydrolase (LAH) activity.  Hydrolyzes phospholipids as well as galactolipids.  May play a role in disease resistance (By similarity).
What are the official names of this protein?
Patatin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
Protein: NGFV_OXYSC
Sequence: MSMLCYTLIIVFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRETHPVHNLGEYSVCDSISVWVANKTEAMDIKGKPVTVMVDVNLNNHVFKQYFFETKCRNPNPVPSGCRGIDSGHWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVISRKTENF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor, v-NGF, vNGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SELA_SHIFL
Sequence: MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRGSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLVAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_LACLA
Sequence: MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDKSFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMPIWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLEEKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADGLKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMGPLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKALPLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIGRESVAEALEGKNVVKVIAVPNKLVNIVVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_PSE14
Sequence: MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGVPVFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKLPEDFHILASTPSCPIAGMADDARGYYGVQFHPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLEGESDPEKKRKIIGRTFIDVFDAESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDFMTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CTU2_EMENI
Sequence: MEKYRLRRDLPRSGPCPVLLPLSYGLSSSVLLHMVHGQVERLLTKPHPPPGFELHVLIVEPSSISPSNPSHRGAFQLLQQQFPHASFTQLPLHSVFDYVSGLNDILAEYVGPAFVDDTSLPSKERLDAFRASITSATSAADVDSVLLNRLIIAFARSLGCLGIIWGDSDDRLAAKTLANVSKGRGSSLTWQVSDGTSPFGLEFSFPLRDLFTAELQSYANFFPELLNIIIPDGPLSDNILTKNLSIDQLMMRYVSSQGAKYPGVMSNVTRTVNKLESSRMITDGLRCALCDTFICNPEGRQTMDLEERPTNHFCYACERSRPGLS
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_RHOP5
Sequence: MSDILTRIEAYKREEIAAAKRARPIAELEVAAKTASPPRGFVAAIRRKLAEGDYALIAEIKKASPSKGLIRVDFDPPALAQAYQAGGAACLSVLTDTPSFQGHLDFMVAAREAVALPVLRKDFVYDTYQVVEARAHGADCILIIMAALDDATAKDIEDAAIDLGMDVLIEIHNHDELERALKLRSPMIGVNNRNLRTFDVTLATSEALAPLIPSERLMVGESGIFAPADLARLERVGIATFLVGESLMRQSDVTAATRALLARDAALRPTGTV
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: PVK21_SHELA
Sequence: GSSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2.1, Pea-PVK-2-like peptide, Periviscerokinin-3, SheLa-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RAB9B_HUMAN
Sequence: MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFIYYADVKDPEHFPFVVLGNKVDKEDRQVTTEEAQTWCMENGDYPYLETSAKDDTNVTVAFEEAVRQVLAVEEQLEHCMLGHTIDLNSGSKAGSSCC
What is the function of this protein?
Involved in the transport of proteins between the endosomes and the trans Golgi network.
What are the official names of this protein?
Ras-related protein Rab-9B, Rab-9-like protein, Rab-9L.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Protein: Y659_VIBVY
Sequence: MLIVVSPAKTLDYESPLVTHKFTQPELVDYSKQLIEVCRQLTPADVASLMKVSDKIADLNVGRFQEWSEEFTPDNARQAILAFKGDVYTGLEAETLNDDDFDYAQKHLRMLSGLYGLLKPLDLMQPYRLEMGTKLANPKGSNLYQFWGNVITEKLNEAIAAQGDNVLINLASNEYFKAVKPKALDAQVITPIFKDAKNGQYKVISFFAKKARGMMARYIIENRISSVADLTQFDSAGYYFVEEESTPTELVFKREEQH
What are the official names of this protein?
UPF0246 protein VV0659.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RHAD_ECO8A
Sequence: MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYKDNFHAQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGSTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_SHEDO
Sequence: MKPFPRAEISRKALQANLARIRELAPQSKIMAVVKANGYGHGLLNVANSVATYDQGADGFGLARLEEALELRSGGVNARLLLLEGFFRVTDLPLLVQHHIDTVVHHESQVEMLEQAELTTPVTVWMKIDTGMHRLGFSLAQFDAIYQRLLACHNIAKPIHLMTHFACSDEPDNSFTQAQIDAFESVTASLDGDRSLANSGGMLFWPQSQRDWIRAGIALYGVSPMVGDKGGNHGLVPAMELKSQLISVKDHQAGDSVGYGAFWRARKDTRIGVVAIGYGDGYPRHAPEGTPVWLNGRRVPIVGRVSMDMLTVDLGLDSQDKVGDEVLLWGSALAVEEVADHIGTIAYELVTKLTPRVAVALLP
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: SYT_RHOBA
Sequence: MSADSPSSPASSQAAEVQVRLPDGSLKTQPADATAMDVAKEISEGLARSVVAAEVDGTIVDSFRPLGEIADDENVVPLRLLTTRDESALDVLRHSAAHVMARAIMRIYKGVSLAFGPTTSGGFYYDFDMPEKISEDDFPKIEAEIKKIIKAKEPFERFVLERDEARKLCDDLDQDLKVEHIETGLGDQATVSFYRQGEFVDLCRGPHIPHAGMIKAIKLLSVAGAYWKGDASGRQLQRVYGTAFFDKKELASYLEQIEEAKRRDHRVLGKQHGLFAINPEVGQGLCLWLPKGARVRVTLEDFLRRELLSRGYDPVYSPHIGRVEMYETSGHFPYYRDSQFAPLFGSEVGGLLDAWSTRLDKDDLSKDDEDKLIAAAEVFGVKLPDYKPSASNDAKKDVLHRWQLNHERYLLKPMNCPHHCQIFGAQPRSYRQLPLRLFEFGTVYRHEQTGELNGMMRVRGLTQDDAHIFCTADQVEEEFRATIELTKFVLESVGLDDYRVQLSLRDPDSSKYVGSEENWDHAEGALRGVLEQSGLSFNEEPGEAAFYGPKADFMVRDCIGRSWQLGTVQLDYNLPERFKLEYKGNDNATHRPVMIHRAPFGSLERFTGMLIEHFAGAFPMWLSPEQIRVLPLSDKSVEYATAVAKQLDEAGFKVTVDASDGKVQAKIRNAQIDLVNYMAVVGPKEAESGQVALRDRIEGDLGSMPIKEAIARLQKEVETRQVRQAVKGSTVSIAETGGAATDY
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_VIBA3
Sequence: MSKQKHSASSGRWLKEHFDDKYANEARKKGYRSRAYFKMEEIQTKDKLLTPGMTIVDLGAAPGGWSQYAAKIIGDNGQIIACDLLPMDPIAGVSFLQGDFREEAVLDALLERIQPNMVDVVMSDMAPNIAGNNSVDQPRAMYLVELALDMCRQVLATNGSFVVKVFQGEGFDQYVKDVREMFKTVKVRKPDSSRARSREVFIVATGYKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOS3_YEAS7
Sequence: MVLLKEPVQPLPRSSLLYNNASNSSSRIKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFMCHYGKSDAASVSTNLETFHELKVSPPSSCKRVELVSLPVNSSFASLDSVYMENFDHNNLRTGADRNSTYSPSIYDANTLSPSAYHNIGSRESSYSSFSSFTSSTAFASQISIQDAPAIGDQQCLIGESGSSLRVNSCEFPQYTTMSPVGEYPFESTEASLSSTLTPVGNVPQRIKAHLVEGKSNSKDDLRIEADASLVFEASDAQRTRRRMSLYKL
What is the function of this protein?
One of the three SNF1 protein kinases (with SAK1 and ELM1) which are required for growth on nonfermentable carbon sources and nonpreferred sugars and for response to environmental stress.  Activates SNF1 by phosphorylation of its activation-loop 'Thr-210'.  Required for the regulation by SNF1 of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.  Phosphorylates also GAL83, MIG1 and SIP2 (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase TOS3, Target of SBF protein 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: MATK_LEMGI
Sequence: MEEFKGYLQKGGFKQQHFLYPLLFQEYIYGLAHDQGLNVNASTFNEPPEISGYGNKYSSLLVKRLIIRIYQQNSFLYSVNNSKQNRFVGHNKNYYYKMICEGFSIVVEIPFSLRLVSSIKETKEIMKFQNLRSIHSLFPFLEDKFSHLNSVSDIVIPYPIHLEILLQILQCWIQDVPTLHLLRLIFYDYHNRSNSITPNKSSYGFSKDNPRLYRFLYNSYVVECESIFYFLRKSSSYLRSTSFRPLLERTHFYGKMKHIGVTCCNDFQKTLWLFKDPFMHYVRYQGKCIIASKGTHLLMKKWKSYFVNLWQCHFHFWSQPSRIHINQFPHFSFYFLGYLSSVPINLSSAKSQMLENAFLIDTFTPKFETMISIIPMIGSLAKAKFCNLSGNPISKPAWAELSDSDIIDRFGRIYRNLSHYYSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRAFLQRLGSEFFEEFFMEEEKVLSLILPRTYYPLHQLSREPIWYLDIIRINDLVNHFDL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CUPC6_CANPG
Sequence: ALVGPSGMILADGTPVQFPAHAKPVLTGPSGIVFSNGQNIQLH
What are the official names of this protein?
Cuticle protein CP434, CPCP434.
Protein: GT253_MOUSE
Sequence: MHVARLLPLLLLLGQQLRAASVTEPTLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNMDNTTGMLREWLAAVGRDYATVVWKPEEEARSYPDEQGPKHWTKERHQFLMELRQEALAFARDWGADYILFADTDNILTNNQTLKLLIDRQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRQGCFRVPMVHSTFLLSLQTEETARLAFYPPHPNYSWPFDDIIVFAYACQAAGVSMHVCNDHRYGYMNVVVKPHQSLEEEKTNFIHLILEALVDGPPMLASAHVSRPPKKLSKMGFDEVFVISLARRPQRRARMLSSLWEMEISAQVVDAVDGRTLNSSILKHLGVDLLPGYQDPYSGHTLTKGEVGCFLSHYSIWEEVVARGLARVVVFEDDVRFKDNFRRRLERLMEDVLIQKLSWDLIYLGRKQVNPEEEVAVEGLPGLVVAGYSYWTLAYTLSLAGARKLLASQPLHRMLPVDEFLPVMFDRHPNDQYKAYFWPRDLQAFSARPLLASPTHYSGDAEWLSDTETSSPWDDDSGRLISQTGSQKALRGPHLHLTGSSGHSLHPHHRDEL
What is the function of this protein?
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier.  Does not express any beta-galactosyltransferase activity in vitro.
What are the official names of this protein?
Inactive glycosyltransferase 25 family member 3, Cerebral endothelial cell adhesion molecule.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 25 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: S47A2_RABIT
Sequence: MNTAFAGFDENRAGRRAPGCTGRPAFGLGMDSQQDVVNLDQGGCCPALRKLLPRGFWDEARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSVGAGLSSACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPAVSRLTQDYAMIFIPGLPAIFLYSLLAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSMLMMCVEWWAYEIGSFLMGLLGVVDLSGQAIIYEVATVVYMIPMGLGMAVCVRVGTALGAADTLQAKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPIYIVFQLVEAVCCVFGGVLRGTGKQAFGAIVNAIMYYIVGLPLGIVLTFVVGMRIMGLWLGMLTCIFLAAVTFVVYAVQLDWKLAAEEAQKHAGLQQQQQQQQQQGAECTAPSPGPDKAVVSSVATGCNPGIALTMYSRPGCHVDFYGRPEAAPAPAAPASRLSVRQLLFRRGAALAASVAVLMAGLLVRVLTTGY
What is the function of this protein?
Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17442726).  Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine or the antidiabetic drug metformin.  Mediates the efflux of the endogenous compounds creatinine, thiamine and estrone-3-sulfate.  Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney (By similarity).
What are the official names of this protein?
Multidrug and toxin extrusion protein 2, MATE-2, MATE2-K, Solute carrier family 47 member 2.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly found in the apical membrane of RPT cells.
Protein: PDXH_CAUVC
Sequence: MSADPTLIPASPSEDDYVRQVREATPPPLLSEEDPFALFAEWLEEAGKKEPNDPNAMTVSTVDADGMPDSRMVLLKDFDARGFVFYTNTQSAKGQELNAHPKAALLFHWKSLRRQVRIRGTVEPVTEAEADAYFASRARHSQIGAWASDQSQPLPDRHALEKRVAEMGLKFGLGKVPRPPHWSGYRITPVTIEFWRDRPFRLHERLVFDRADGGWTTKRLFP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: ZMY10_RAT
Sequence: MGDLELLLPGEAEVLVQGLHSFQLREMGSEGWSKQHENLEKLNMQAILDATVSQAEPIQELLVTHGKIPTLVEELIAVEMWKQKVFPVLCRLEDFKPQNTFPIYMVVHHEASIINLLETVFFHKEVCESADDTVLDLVDYCHRKLILLVARKGGGDLSEEERFQDSTPMQELQKQAEMMEFEISLKALSVLRYITDCMDSLSLSTLNRMLTTHNLPCLLVELLEHSPWSRREGGKLQHFESGRWQTVAPSEHQKLNKLDGQVWIALYNLLLSPEARTRYCLTNFAKGQLLKLQAFLTDTLLDQLPNLADLKSFLAHLALVETQPPKKDLVLEQIPEIWDRLERENKGKWQAIAKHQLQHVFSLSEKDLRQQAQRWAETYRLDVLEAVAPERPRCAYCSAEASKRCSRCQKVWYCCRECQVKHWEKHGKTCVLAAQGDRAK
What is the function of this protein?
Plays a role in axonemal structure organization and motility.  Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity).  May act by indirectly regulating transcription of dynein proteins (By similarity).
What are the official names of this protein?
Zinc finger MYND domain-containing protein 10.
What is the protein family that this protein belongs to?
Belongs to the ZMYND10 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle.
Protein: ISPH_CALS4
Sequence: MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEEEELEKLLKGDRLIIRSHGISKKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIVIVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKACAVSQTTLIEKHWEDILEVLKSKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYHIERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: LPPN_MYCTO
Sequence: MRLPGRHVLYALSAVTMLAACSSNGARGGIASTNMNPTNPPATAETATVSPTPAPQSARTETWINLQVGDCLADLPPADLSRITVTIVDCATAHSAEVYLRAPVAVDAAVVSMANRDCAAGFAPYTGQSVDTSPYSVAYLIDSHQDRTGADPTPSTVICLLQPANGQLLTGSARR
What are the official names of this protein?
Putative lipoprotein LppN.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.