PharMolix/UniProtQA huggingface dataset:
Protein: MDR1_CRIGR
Sequence: MEFEEDFSGRKDKNFLKMGRKSKKEKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKR
What is the function of this protein?
Translocates drugs and phospholipids across the membrane.  Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane.  Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins.  Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
What are the official names of this protein?
ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane.
Protein: P19_TBSVT
Sequence: MERAIQGNDAREQANSERWDGGSGSSTSPFQLPDESPSWTEWRLHNDETNSNQDNPLGFKESWGFGKVVFKRYLRYERTETSLHRVLGSWTGDSVNYAASRFFGVNQIGCTYSIRFRGVSVTISGGSRTLQHLCEMAIRSKQELLQLTPVEVESNVSRGCPEGVETFEEESE
What is the function of this protein?
Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs).  Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).
What are the official names of this protein?
RNA silencing suppressor p19, 19 kDa symptom severity modulator.
What is the protein family that this protein belongs to?
Belongs to the tombusvirus protein p19 family.
Protein: SPRL1_MOUSE
Sequence: MKAVLLLLCALGTAVAIPTSTRFLSDHSNPTTATLVTPEDATVPIAGVEATADIENHPSDKAEKPSALNSEEETHEQSTEQDKTYSFEVDLKDEEDGDGDLSVDPTEGTLTLDLQEGTSEPQQKSLPENGDFPATVSTSYVDPNQRANITKGKESQEQPVSDSHQQPNESSKQTQDLKAEESQTQDPDIPNEEEEEEEDEEEEEEEEPEDIGAPSDNQEEGKEPLEEQPTSKWEGNREQSDDTLEESSQPTQISKTEKHQSEQGNQGQESDSEAEGEDKAAGSKEHIPHTEQQDQEGKAGLEAIGNQKDTDEKAVSTEPTDAAVVPRSHGGAGDNGGGDDSKHGAGDDYFIPSQEFLEAERMHSLSYYLKYGGGEETTTGESENRREAADNQEAKKAESSPNAEPSDEGNSREHSAGSCTNFQCKRGHICKTDPQGKPHCVCQDPETCPPAKILDQACGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPACTDFEVAQFPLRMRDWLKNILMQLYEPNPKHGGYLNEKQRSKVKKIYLDEKRLLAGDHPIELLLRDFKKNYHMYVYPVHWQFNELDQHPADRILTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDENLLF
What are the official names of this protein?
SPARC-like protein 1, Extracellular matrix protein 2, Matrix glycoprotein Sc1.
What is the protein family that this protein belongs to?
Belongs to the SPARC family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: GMHA_PELPB
Sequence: MIKGCGCSDGLTDRTRYEEVVLDTMLYSAQLKERVARQNSAVIVAMARMIAGTFEDGGKVLLCGNGGSAADAQHLATELTIRYRSSVERPALPAIALSTDTSALTAGANDLGYDAVFARLVEAYGREGDILLGLSTSGNSQSVINALDFARQQGMKTLALLGGNGGLMKGLADLELIVPHSGSADRVQECHITIGHVLIDLVERMLGYCRL
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INTM_ECOLI
Sequence: MNNVIPLQNSPERVSLLPIAPGVDFATALSLRRMATSTGATPAYLLAPEVSALLFYMPDQRHHMLFATLWNTGMRIGEARMLTPESFDLDGVRPFVRILSEKVRARRGRPPKDEVRLVPLTDISYVRQMESWMITTRPRRREPLWAVTDETMRNWLKQAVRRAEADGVHFSIPVTPHTFRHSYIMHMLYHRQPRKVIQALAGHRDPRSMEVYTRVFALDMAATLAVPFTGDGRDAAEILRTLPPLK
What are the official names of this protein?
Probable site-specific recombinase.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: VG39_BPMD2
Sequence: MYEAEDHEFFDVLYQQWSHTTEAKSRYWVVEFDGDEHLQWQVFAVDQTDGSKLWLGSFHREQDADFVAGLHGALPDLIRRLHDATDEAVRKDEANDIAQGQLAEALLENQGLKAQILELERQLDKETS
What are the official names of this protein?
Gene 39 protein, Gp39.
Protein: TRPD_NOCSJ
Sequence: MSTWPEVLGALVAGSDLSADQTAWAMGEILSGEATVAQIAGFAIALRAKGETVEEVSGLVDTMYALATPISVPGRLLDIVGTGGDRSMSVNISTMSAIVAAGAGARVVKHGNRSASSQSGSADVLESLGIRLDLPAARLAEIAAEVGITFCFAAAFHPAMRYAAVPRRELGVGTTFNFLGPLTNPAHAHAQAIGCADPRMAPVMAGVFARRGVDAWVFRGDDGLDELTTTTTSRLWWVHGGEVRETSVDPADLGIARAEAGALRGGDAAHNAEVVRRLLAGETGAVRDAVVLNAGAALAVYDEPGSAPDQALVAGVERARESLDSGAAARVLDRWVAATAR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PQQB_XANCP
Sequence: MRIIVLGSAAGGGHPQWNCHTPASQRAWQQADGAQRRTQASIAVSADGQRWVLINASPDFRQQILATPALWPQHGLRHSPIESVLLTSGEIDHIAGLLSMRESQRFSLHASSRVLDLLAQNPIFDALNPQYVDRHPFALNTPLTLCDLQLTPFSVPGKVPLFMESRSGGDLAGSNEETLGLTIDDGRHRVHYIPGCAAMTDDLRARLHGAELVFFDGTLWRDDEMVQLGVSQKTGQRMGHMSIDGTDGTLAAFAQLQVARKVLIHINTTNPVLDAHSPEHAAVRAAGWDVAHDGLEISL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: FOXJ3_MOUSE
Sequence: MGLYGQACPSVTSLRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDPNTTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKEDTLPTRPKKRARSVERASTPYSIDSDSLGMECIISGSASPTLAINTVTNKVTLYNADQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTNHPEPVSQPLTPQQQQQPQYNLPEREKQLLFTEYNFEDLSASFRSLYKSVFEQSLSQQGLMSIPSESSQQSHTSCSYQHSPSSTVTSHPHSNQSSLPNNHSGLSATGSNSVAQVSLSHPQMHPQPSPHTPHRPHGLPQHPQRPQHPAPHPQQHSQLQPPHSQHPPPHQHIQHHPNHQHQTLAHQPPPPPQQVSCNSGVSSDWYATLDMLKESCRIASSVNWSDVDLSQFQGLMESMRQADLKNWSLDQVQFADLCSSLNQFFTQTGLIHSQSNVPQNVCHGAMHPAKPSQHIGAGNLYIDSRQSLPPSVMPPPGYPHIPQALNTPGTTMAGHHGAMNQQHMMPSQAFPMRRPLPPDDIQDDFDWDSIV
What is the function of this protein?
Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (PubMed:19914232).  Plays an important role in spermatogenesis (PubMed:27739607).  Required for the survival of spermatogonia and participates in spermatocyte meiosis (PubMed:27739607).
What are the official names of this protein?
Forkhead box protein J3.
What are the subcellular locations of this protein?
Nucleus.
Protein: CEMA_HUPLU
Sequence: MKFKLYWWEVFRWFSDTPSRSSERACEASRQVQHIKKDYVSYKCLVPSLPKHSWQAIILYMNTRLNNFVFIIYWSVLECKTSIYLLNILNKLGLIVSVPGKSFSSPKLLINIRSFFNGNKRLRIMSQSNPYNIWLYPLNILLSFPVHRKPKKLRSTEKIFEKNGFNCENREYPHDKNDKTYFVSGKSSEEELVRIERMNQKLAWIEATLNDLDNWKRYYSLSSFSFEMGDIPEEGQSSLSVEGESDSIVTTIAYESIGLVPRSITRTLSRFKTELTGQSSSLVLYEFRLAKYQALASLQYLGCLILIPWGISFPSERWLLKPWIKNWWNINQFQIFLNYFQEERASKRLQEVEELLWLDEVMLADSSSSEVQSQDLNRQIHDKTIQLVAMYNEDSIQTILHLLTDIIYFAIPSASFISGKKRLAVMNSWIQESFHSLSDTMKAFFILLLTDSCIGFHSPHGWEILISSLSKHLGFAHNKHIISCFVSTFPVISDTVFKYWIFRHLNRISPSIVATYHAMNE
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: KSHA1_RHORH
Sequence: MSLGTSEQSEIREIVAGSAPARFARGWHCLGLAKDFKDGKPHSVHAFGTKLVVWADSNDEIRILDAYCRHMGGDLSQGTVKGDEIACPFHDWRWGGNGRCKNIPYARRVPPIAKTRAWHTLDQDGLLFVWHDPQGNPPPADVTIPRIAGATSDEWTDWVWYTTEVDTNCREIIDNIVDMAHFFYVHYSFPVYFKNVFEGHVASQFMRGQAREDTRPHANGQPKMIGSRSDASYFGPSFMIDDLVYEYEGYDVESVLINCHYPVSQDKFVLMYGMIVKKSDRLEGEKALQTAQQFGNFIAKGFEQDIEIWRNKTRIDNPLLCEEDGPVYQLRRWYEQFYVDVEDVAPEMTDRFEFEMDTTRPVAAWMKEVEANIARKAALDTETRSAPEQSTTAG
What is the function of this protein?
May be involved in the degradation of cholic acid, a steroid acid found predominantly in the bile (PubMed:21642460).  In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 23,24-bisnorcholesta-4-ene-22-oate, 3-oxo-23,24-bisnorcholaesta-1,4-dien-22-oate (1,4-BNC), 23,24-bisnorcholesta-1,4-diene-22-oate and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) (PubMed:21642460, PubMed:25049233).  KshA1 has the highest specificity for steroids possessing an isopropionyl side chain at C17 (PubMed:25049233).
What are the official names of this protein?
3-ketosteroid-9-alpha-monooxygenase, oxygenase component, 3-ketosteroid-9-alpha-hydroxylase, oxygenase component, KSH, Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase, Rieske-type oxygenase, RO.
Protein: OPSD_LACLU
Sequence: LHMIHLHWYQYPPMNPMMYPLLLVFMLITGILCLAGNFVTIWVFMNTKSLRTPANLLVVNLAMSDFLMMFTMFPPMMITCYYHTWTLGATFCEVYAFLGNLCGCASIWTMVFITFDRYNVIVKGVAGEPLSTKKASLWILTVWVLSFTWCVAPFFGWNRYVPEGNLTGCGTDYLSEDILSRSYLYIYSTWVYFLPLAITIYCYVFIIKAVAAHEKGMRDQAKKMGIKSLRNEEAQKTSAECRLAKIAMTTVALWFIAWTPYLLINWVGMFARSYLSPVYTIWGYVFAKANAVYNPIVYAIS
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Can use both retinal and 3-dehydroretinal as visual pigment.  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Signaling via GNAQ probably mediates the activation of phospholipase C.
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Note=Detected on the rhabdomere membrane in the photoreceptor outer segment.
Protein: HEM3_EXISA
Sequence: MRKIIVGSRRSQLAMTQTKWVIEQLKQAGATNEFEIKEIVTKGDQIVDVQLSKVGGKGLFVKEIQQQMLDGDIDFAVHSMKDVPAELPEELYISCMPKRVDARDVLICENGYTFETLPKGSIVGTSSLRRGAQILAARPDLEIQWIRGNIDTRLKKLDSENYNAILLAKAGLERMGWTDRVDFEALDPDVMVPAVGQGVLAIESRKDDAEVTTVLQLLHDDVTAKAATAERTFLKAIEGSCHVPVGGYATVNGDDVTLTGLIASVDGKEVLRVTKTSTDGVALGQAVAEELLGRGGREILASVNE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PSAJ_ORYSI
Sequence: MRDIKTYLSVAPVLSTLWFGALAGLLIEINRLFPDALSFPFFSF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: INS_ONCGO
Sequence: AAAQHLCGSHLVDALYLVCGEKGFFYNPKGIVEQCCHKPCNIFDLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: APTX_XENTR
Sequence: MIECWLVSKDGKHGRIRLPHAETVVIGRGPETQITDKKCSRHQVQLMADCNKGYVKVKQLGTNPTSIDGVDIGKEQKVDLKPGHTLHIVNNLYPYVIEFLEGATNPHAKRENENRSSSKRTQENSLNEGTGTSMKLMKKESNISPSSSSGKNSSCSTEEKYNAQEVKSQGHWSQGLKASMQDPTMQVFKDDKVVVIKDKYPKARYHWLVLPWQSIANLKVLRAEHLELVQHMHAVGQKIAKEHSDSKCAPFQLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFTTDYFLESQAMIEMIKTHGKVNVKDGVSELLKTPLMCHICRKEQANMPQLKEHLKKHWPT
What is the function of this protein?
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair.  Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species.  Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined.  Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity).  Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
What are the official names of this protein?
Aprataxin, Forkhead-associated domain histidine triad-like protein, FHA-HIT.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus.
Protein: MIC13_DANRE
Sequence: MAAKIFPVVKFATKVTIAGGALYVAYDSGLLGGSNEGSVALARAKSAIPPAVDEWMKYFGFELPATPKIEFSPLDAWNSGVQKSIHALSVAPSTVGDYTKQGLQYVKDLSK
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology.  Required for the incorporation of MIC10 into the MICOS complex.
What are the official names of this protein?
MICOS complex subunit MIC13.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic13 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=Enriched at crista junctions.
Protein: YFEE_YERPE
Sequence: MTYQQAGRVAVIKRIAGWLVFIPALLSTLISIINFVYLYSQKGTGVNAVMLDFIHVMTDMARFNTPFLNIFWYNSPVPNLEQGLSAGNIMFFIIYMLIFVGLSLQASGARMSRQVRHIREGIEDQMILERAKGNEGHSREQLEEKIVLPHHTIFLQFFTLYILPSVIGVLGYFVIKLLGIMIQG
What is the function of this protein?
Putative regulator of YfeABCD, an ABC transporter locus involved in inorganic iron transport.
What are the official names of this protein?
Putative YfeABCD regulator YfeE.
What is the protein family that this protein belongs to?
To E.coli YniB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PGMG_ASPTN
Sequence: MSETVTQTETDQRPATARSLGAEEKEAKSDEQFQQERTIKGFRWFIVIISILSSVTLYSLDNTIVADIQPQIINTFDELDKLPWLSVAFLVACVATNSIWSKIYSQLNAKWLYLFCVVLFEVGSAMCGAAPTINTLIGGRALAGLGGAGLYVGVMTLLSVNTSKRERPMYIGMTGLTWGVGTVLGPIVGGGFAVSKVGWRWSFYINRECRPSVQPIRPLTVPPVFFAAVAIPIYLFMLPSFDPRPGVSYKERLAQLDYLGTILMIGACVSGVMAINFGGQIYPWDSGQTISCFVVSGVLFIVFGLQQWYCIGTTKENRTFPCQFLARPAFIILFVQTASVATVFFVPIYFVPLFFQFTRNDSAIDAGVRLLPLVCFIVAAMILNGALMSKFGYYMPWYLVGGCLSLVGSVLMYTIKLGTSTANIYGYMIILGVGGGMYAQASFAVAQGKARPREIPVATGFISLAQLTGGTIALAIANSVFLEKASAGIMAVVPDASKETVQSAISGASSSFFQTLDPDVREAVLAAVTHAISQVYILPITGAAMSISLAIFMPREKLFVASDSGDRDGVTPLGAMG
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of pleosporalin A, ascomycone A, as well as a third cryptic naphthoquinone derived pigment, all responsible for the coloration of conidia (PubMed:28471414, PubMed:35351612).  Seems not to be involved in pigment biosynthesis although its expression is regulated by the cluster-specific transcription factor pgmR (PubMed:35351612).
What are the official names of this protein?
MFS-type transporter pgmG, Pigmented naphthoquinones biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEXA_HAHCH
Sequence: MIKLTKRQEQVLQLIREHIEETGYPPTRAEISNRLGFRSANAAEEHLKALAKKGAIEMVPGASRGIRLPASETQNQGIPIVGQVAAGYPILAQENIEEYCELPPSFFTPSADYFLRVKGMSMKDVGILDGDLLAVHRTTDIHNGQIVVARIGDEVTVKRFQRQKNKVLLLPENEEFEPIEVNLSQQPLDIEGLGVGVIRR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: UVRC_RHOP2
Sequence: MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEIEDDSAEVADGPLAVGRAAIEQAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYARPTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQLRPRFNVLLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCLLYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAALYRDRLAALSAIQSQQGINPRTVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLADALCIKADRKVEISTPKRGEKKELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDDETPQWPDLVIIDGGRGQLNAARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGTLKEIERASLGDLGKVPGISAESARRIFDFFHPGPG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGCR1_RHIO9
Sequence: MTHPDRSAHDLNVPIQHSGRWFQDNLGRTLLLRGINVCGSSKLPTRPYPGSTHLYDDILFWDHRNVSFVNRPFPLEDAHEHFSRLSAWGLTLIRLLVPWESIEHEGPGCYDEEYIDYLRQLIEMMPRYGIKCIIDPHQDTWSRFSGGSGAPGWTFEVAGLNIKHFKETGAAYVHNTNAVPGDPLPMVWPTNYTKLASCTMFTLFFAGDTFAPHRTYQSQSIQQFLNHHFIEAYRHLAERLSDLEAVLAFEFMNEPHPGYIGLDHLDSFDPIMNLLFGDSPTPLQSFALGDGIPQTVDVYIKSWPFPTKKSHDRVINASQTSAWFSGCVWKEHGVWTVDDQGVPRLVNTHYFSKHPKTGEKISFYEDFYKPLVNRYVAAIQSVKKEYYCLVEPLANEKPPVYNEHDHHHNVIFSPHWYDLDSVFYKKFNARMTHDVQCLQRGGNVFSATYFGKRGAKKNYRGQIKNIKEDGLLNMGEKPCIMGEVGIPMDLNNKMAFEDDNYENHVHFMDAIIYALETNLISFTLWNYDVFNDHEYGDHWNGENFSIYSVKKSEEDYMRHDDGNSKLSKKHLYDGGRVLEAVLRPYAAKVAGTPVSAEFNIDTLQYTFSFIPDCKGSTTTEIFVPYFHYGNKTIKTDVSFGRCSYIEEFQTLYHQYELNDPLPKLVTITMGILTTESANSCSVM
What is the function of this protein?
Specifically hydrolyzes the glucosidic linkage in glucosylceramide (PubMed:22072709).  May prevent accumulation of aberrent glucosylceramide containing immature ceramide (By similarity).
What are the official names of this protein?
Glucosylceramidase, Endoglycoceramidase-related protein 1, EGCrP1, Glucocerebrosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: NFI_KLEP3
Sequence: MDLAALRTQQQQLAASVERADRLDRDPPALIGGADVGFEQEGEVTRAAMVLLTWPELELVEYQVARVATTMPYIPGFLSFRETPALLAAWEQLSQKPDLLFVDGHGISHPRRLGVASHFGLMIDVPTIGVAKKRLCGKIGELGDEPGALAPLMDKNEQLAWVWRSKVRCNPLFISTGHRVGMDSALMWVERCMRGYRLPEPTRWADAVASRRPSFVRWQANHG
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNA_CRIGR
Sequence: MFEARLVQGSILKKVLEALKDLINEACWDISSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSTDVPLVVEYKISDMGHLKYYLAPKIEDEEGS
What is the function of this protein?
Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.  Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities.  Has to be loaded onto DNA in order to be able to stimulate APEX2.  Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.  Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).
What are the official names of this protein?
Proliferating cell nuclear antigen, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
What are the subcellular locations of this protein?
Nucleus. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (By similarity).