PharMolix/UniProtQA huggingface dataset:
Protein: HEM4_CHLTE
Sequence: MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSVQFFLERLLEESPDELPNLQQARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQPSLEETQKIKSLLTEGKIDCLSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKAIAAALS
What is the function of this protein?
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
What are the official names of this protein?
Uroporphyrinogen-III synthase, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen-III synthase family.
Protein: PLSX_PEDPA
Sequence: MKIAVDAMGGDNAPEEIVKGVSEARKALPDVEFILYGKKDEIAKYMDDFRNVKVVHTDEVITMEDEPVKAVRRKKNSSMILAAQAVKNGDADAIFSAGNTGALLAAGLFIIGRIKGLDRPGMTTTLPSLKGENDNFTMLDVGANAESKAKNLHDFAILGNFYGTNVMHVTNPRIALLNNGTEYDKGDKIHKEAYQLLKNDSSLNFVGNIESRELLNGTADVVVTDGFTGNAVLKNIEGTALSMLKLVKETIMNNGVKGKMGGLLLKSAFSQIKDQMDYSKQGGAVLLGVKAPVVKAHGSSNANQVKNALVQVHEIVDSKLVKNLADYFEMHLESIKQDDVDKENENN
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ENGB_BARHE
Sequence: MTEYSSLSGIFFHNWVFIRGVPTIRFLPPEGPPEIAFAGRSNVGKSSLINALVRQKSLARTSNMPGRTQELNYFVPDGFSGRPEDLPPIALVDMPGYGFAKAPKNLVDAWTDLIYSYLRGRTTLKRVYVLIDSRHGIKKNDAEILELLDKAAVSYQIVLTKSDKIKSSVLEQRIITTKTKLLKRPAAYPEILATSSEKAFGLEELRAAILQTIAV
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: KLRD1_PONPY
Sequence: MAVFKTTLWWLISGTLGIICLSLTATLGILLKNSFTKLSIEPAFTPGPDIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQYLFPLFETFNPKNCIAYNPNGNALDESCEDKNRYICKQQLI
What is the function of this protein?
KLRD1-KLRC2 acts as an immune activating receptor.  On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy.  Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection.  Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
What are the official names of this protein?
Natural killer cells antigen CD94, Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Popy-CD94.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: Y264_MYCPN
Sequence: MIDLLGLDLDGTLLSRTRQINDPTKQALANLIQKKPSLKVMILTGRSLFSTLKYVQELNELCKKPLVEYFCCYGGAKLYQLNNNQPQEQYKFLIDSRQVKTVFEIVEQHKGLFLAYLDKPKAPYIILGANQFYAWLIKQFWYKQRCEYFKNDHLTDGILKINVYFACPLRLKKVYQIIKRQFQDTLNVVNFSKHLIEITHKDGNKGYAIEAIAKKQGLSLKRMAVIGDSLNDRSMFEKVQYSFAMSKSPDELKLLATEIGTKTNRFRFSSLVDLITEKIIN
What are the official names of this protein?
Putative phosphatase MPN_264.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: GUX2_THES1
Sequence: MKRRLMKGISLLTLVFLIGIMLQLSLKSELTAYASSDDPYKQRFLELWEELHDPSNGYFSSHGIPYHAVETLIVEAPDYGHLTTSEAMSYYLWLEALYGKFTGDFSYFMKAWETIEKYMIPTEQDQPNRSMAGYNPAKPATYAPEWEEPSMYPSQLDFSAPVGIDPIYNELVSTYGTNTIYGMHWLLDVDNWYGFGRRADRISSPAYINTFQRGSQESVWETIPQPCWDDLTIGGRNGFLDLFVGDSQYSAQFKYTNAPDADARAIQATYWANQWAKEHGVNLSQYVKKASRMGDYLRYAMFDKYFRKIGDSKQAGTGYDAAHYLLSWYYAWGGGITADWAWIIGCSHVHAGYQNPMTAWILANDPEFKPESPNGANDWAKSLERQLEFYQWLQSAEGAIAGGATNSYKGRYETLPAGISTFYGMAYEEHPVYLDPGSNTWFGFQAWTMQRVAEYYYLTGDTRAEQLLDKWVDWIKSVVRLNSDGTFEIPGNLEWSGQPDTWTGTYTGNPNLHVSVVSYGTDLGAAGSLANALLYYAKTSGDDEARNLAKELLDRMWNLYRDDKGLSAPETREDYVRFFEQEVYVPQGWSGTMPNGDRIEPGVTFLDIRSKYLNDPDYPKLQQAYNEGKAPVFNYHRFWAQCDIAIANGLYSILFGSEQANDSFITPTSATFDKNNQEDISVTVTYNGNTLLGIKSGSSYLIEGVDYIVNGDVIIIKKEFLAGQATGSISLLFDFSAGLDRTLTIDIIDTGGGEEPVEPVEPVEGVLIIQSFNANTQEISNSIMPRFRIYNSGNTSIPLSEVKLRYYYTVDGDKPQNFWCDWASIGSSNVTGTFVKMDGATTGADYYLEIGFTPQAGTLEPGASIEVQGRFSKIDWTDYTQTNDYSFNPTASSYVDFNKITAYISGNLVYGIEP
What are the official names of this protein?
Exoglucanase-2, 1,4-beta-cellobiohydrolase II, Avicelase II, Exocellobiohydrolase II, Exoglucanase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 48 (cellulase L) family.
Protein: PANC_STAAW
Sequence: MTKLITTVKEMQHIVKAAKRSGTTIGFIPTMGALHDGHLTMVRESVSTNDITVVSVFVNPLQFGPNEDFDAYPRQIDKDLELVSEVGADIVFHPAVEDMYPGELGIDVKVGPLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGKKDAQQLAIVEQMVKDFNHAVEIIGIDIVREADGLAKSSRNVYLTEQERQEAVHLSKSLLLAQALYQDGERQSKVIIDRVTEYLESHISGRIEEVAVYSYPQLVEQHEITGRIFISLAVKFSKARLIDNIIIGAE
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADPGK_MOUSE
Sequence: MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPVGPLSPESRLAAAWDALIAQPARRWRRVAVGVNACVDVVISGVKLLQALGLSPGSGKDHAILHSRSDLEEAFLYFMGKGAAAERFFSDKETFHDIAQAASEFPGAQHYVGGNAALIGQRFAANTDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWGPFKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTAISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVASLGLNEQELLFLSQSASGPHSSLSSWDGVPDVGMVSDILFWILKEHGRSENRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFTTSHLESGSRIVLNPDKPVVEWHREGITFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEARPD
What is the function of this protein?
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.  GDP and CDP can replace ADP, but with reduced efficiency.
What are the official names of this protein?
ADP-dependent glucokinase, ADP-GK, ADPGK.
What is the protein family that this protein belongs to?
Belongs to the ADP-dependent glucokinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMH_BURCH
Sequence: MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFDALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMAALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGTTFHRIPCLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_INBVI
Sequence: LMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPKCLNCTDLDVALGRPKCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAETAPGGPYIVGTSGSCPNVTNGNGFFATMAWAVPKNNNNKTATNPLTVEVPFICTEGEDQITVWGFHSDSETQMVKLYGDSKPQKFTSSANGVTTHYVSQIGGFPKQAEDGGLPQSGRIVVDYMVQKSGKTGTITYQRGILLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKERGFFGAIAGFLEGGWEGMIAGWHGYTSHGAHGVAVAADLKSTQEAINKITKNLNSLSELEVKNLQRLSGAMDELHNEILELDEKVDDLRADTISSQIELAVLLSNEGIINSEDEHLLALERKLKKMLGPSAVDIGNGCFETKHKCNQTCLDRIAAGTFNAGEFSLPTFDSLNITAASLNDDGLDNHTILLYYSTAASSLAVTLMIAIFIVYMVSRDNVSCSICL
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: FMT_EDWI9
Sequence: MSHSLRIIFAGTPDFAARHLEALLASDHQIVGVFTQPDRPSGRGNKLTPSPVKALALQHDLPVFQPASLRPEENQRLVASLQADVMVVVAYGLILPQAVLDMPRLGCVNVHGSLLPRWRGAAPIQRALWAGDSETGVTIMQMDAGLDTGDMLLKLSCLITQDDTSATLYDKLSALGPQGLLTTLAQLADGRAQAQQQDDALACYAEKLSKEEARLDWQLPAEQLARCVRAFNPWPVSFFMLEGQPVKVWGANVLHQESDAQPGTIVGADKQGIAVATAQGILLLTQLQPAGKKSMAARDLLNSRKESFLAGTLLD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: LIPA_WOLTR
Sequence: MHSKPPWLRAKAPTGEIFNETLNTVKLHGLHTVCEEAACPNIGECWNKRHATVMILGSVCTRACAFCNVATGIPNKLDPHEPENLAKAIKKLNLKYVVITSVDRDDLPDGGASQFIKCIEEIRKITPETTVEILTPDFLNKKGAFEAIAVASPDVYNHNIEMVPRLYARIRPRARYFHSLYLLKMVKQINPKLLTKSGLMVGLGETKEEVLQVMDDLRSAEVDFITIGQYLQPTPKHAKIDRYVTPEEFEHYKYIAYSKGFLVVASSPLTRSSYHAEEDFNRLKACR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_AERHH
Sequence: MSEMTPREIVHELDRHIIGQADAKRAVAVALRNRWRRMQLDEEMRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAIKLVRETEMEKMKYRAEEAAEERILDALLPNPRNSWGEEEKADNSNTRQIFRKKLREGQLDDKEIELELAASPMGVEIMTPPGMEEMANQLQGLFQNLGQNQKKKRKIKVKEAMKALIEEEAARLVNPEELKQKAIAAVENNGIVFLDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVNTKHGMVKTDHILFVASGAFQIAKPSDLIPELQGRLPIRVELTALTTDDFERILTEPNASLTDQYQALMATEGVKIEFTKDGIRRLAEAAWQVNERTENIGARRLHTVMERLMEDISYDASEKSGETFVIDTDYVNAHLGKLIEDEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BURP1
Sequence: MAGETIVNLLDLDAEGLVAYCGSLGEKAFRAKQLQRWIHQYNAADFDGMTDLAKSLREKLKGRAVIGTPDILSDHVSADGTRKWLINVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTGEIVGQLRMAEFALRASLGRAPGPNGKAERVITNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKHPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLVRSKTEQIKRFAQVLIDAGVVTTIRKTRGDDIDAACGQLAGAVKDRTRLAERTGASKIIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR15_SOLLC
Sequence: MVKNSVISVISQEEKKGSVEFQVFNFTNKIRRLTSHLELHKKDYLSQRGLKKILGKRQRLLAYLAKKNRVRYKELINRLDIRETKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FAPR_BACMK
Sequence: MKKRRSKKERQELLQQTIETNPFITDEDLAEKFQVSIQTVRLDRMELSIPELRERIKHVATKQHEEDVKSLPLEEVVGEIIDIELDRHAISIFEVKVEHVFKRNQIARGHHLFAQANSLAVAVIDEELALTAKSTIRYIRPVKLGERVVAKVRVEDVENDKGRTVVKVRSFVGEELVFTGTFEMYRSSNYSEEGNNL
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: RL14_MYCBT
Sequence: MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGRELREKRFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CH601_STRCO
Sequence: MAKILKFDEDARRALERGVNKLADTVKVTIGPKGRNVVIDKKFGAPTITNDGVTIAREVEVEDPYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVREGLKNVAAGASPALLKKGIDAAVAAVSEDLLATARPIDEKSDIAAVAALSAQDQQVGELIAEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYLSPYFVTDQERMEAVLDDPYILINQGKISSIADLLPLLEKVIQANASKPLLIIAEDLEGEALSTLVVNKIRGTFNAVAVKAPGFGDRRKAMLQDMAVLTGATVISEEVGLKLDQVGLEVLGTARRITVTKDDTTIVDGAGKRDEVQGRIAQIKAEIENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKERKHRLEDAISATRAAVEEGIVSGGGSALVHAVKVLEGNLGKTGDEATGVAVVRRAAVEPLRWIAENAGLEGYVITSKVADLDKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTETLVVEKKEEEEPAAGGHSHGHSH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1, HSP58.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMP_GIAIB
Sequence: MPLSEDTIKAVEATADLVAAQGLDFTRAFYERMLTRNEELKDVFNLSHQRDLRQPKALLDSLVAYARSIRKINELHELQEQGLPVPAERLAELQGFFAVAERIAHKHASVGIQPAQYQIVGAHLLATIEERVTADKAILAAWSKAYDFLAHLFVRREEEIYTETESSEGGWRQTRSFRVEEKAQITERIFRFRLVPAEKGTAVALHKPGQYLAVFVRDPRLSPHRQIRQYSITSAPNHTYYEIAVHRDKQATVSGYLHDHVAVGDLLKLAPPYGDFFLEYREPGGQAADGQPSPEPLALHGGAVNFAAERMTPIVLISGGIGQTPLLSILRFLAEKEGQAAIRPIFWIHAAHDSRARAFKAEVDAIKVTDLPGLRTTTFLSEVDETMDKKGEDYDFAGRISLDRVPGLAELEADGANPHYFFVGPAGFMVAVEQQLKAWSVPEDRIHFEMFGPFKPLQ
What is the function of this protein?
Flavohemoprotein involved in nitric oxide (NO) detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the protozoan parasite from various noxious nitrogen compounds.  Therefore, plays a central role in the inducible response to nitrosative stress.  May also be involved in O(2) detoxification (By similarity).
What are the official names of this protein?
Flavohemoprotein, Flavohemoglobin, FlavoHb, Hemoglobin-like protein, Nitric oxide dioxygenase, NO oxygenase, NOD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: SAHH_MYCTU
Sequence: MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_GLOC7
Sequence: MLEILLVFLGGGLGSIARYLMGQLMTIHFPNILSLGTFTVNIIGSFIIGLVISLINKNQWNPQIGLLLATGFCGGFTTFSSFSYENTAYLKNNDYLLSFGYTIMSLFWGFAATFLGIYLVKRG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPO5_HYPBU
Sequence: MARQKKKFNILEHELVPKHEVVPPEEAARIIRELGVRPEQLPWLRATDPVARAIGAKPGDIVRIYRKSPTAGEVVVYRYVVGY
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MREG_DANRE
Sequence: MGTAFKKFCIKFCCCCCCEDEDEEEKAPLIGHDTLDYFDREAKKRRDQETNLWSEPGDPSHSERDDDRVLYKLLQCRQQTQPGSRGYRRLSIDIEAMRDVRREVRDKWKMILENLGFMAEAESLLNVSASASYDRMRNAASARSLLQTLHTETSLFNSKEPPPERYLFILDRLIYLDAAEDFVAKARRFYPPKDDDEEEESNPLGINLPLLLSRMNQNISGGEDEDEDESEPDD
What is the function of this protein?
Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery.  Contributes to retrograde melanosome transport from the cell periphery to the center.  Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell.  Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport.  Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate.
What are the official names of this protein?
Melanoregulin.
What is the protein family that this protein belongs to?
Belongs to the melanoregulin family.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Melanosome membrane; Lipid-anchor. Lysosome membrane; Lipid-anchor. Cytoplasmic vesicle membrane.
Protein: DTD_AZOSB
Sequence: MMALLQRVTRARVTVDGATTGEIGTGLLALVCAEQGDTEAEADKLLAKLLKLRVFADEGGRMNRSLQEVGGGLLVVSQFTLAADTSGGNRPSFANAAPADTGRALYEHFVARARAQHGEVATGRFGAMMQVELVNDGPVTIPLRIPPASAA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXNG2_HUMAN
Sequence: MEEAGLCGLREKADMLCNSESHDILQHQDSNCSATSNKHLLEDEEGRDFITKNRSWVSPVHCTQESRRELPEQEVAPPSGQQALQCNRNKEKVLGKEVLLLMQALNTLSTPEEKLAALCKKYADLGNSPLL
What are the official names of this protein?
Putative gamma-taxilin 2, Gamma-taxilin 2 pseudogene, Taxilin gamma pseudogene, Y-linked.
What is the protein family that this protein belongs to?
Belongs to the taxilin family.
Protein: DHSL_CAUVC
Sequence: MKSLFQRRASKVRETEAMNAPVPNNQKAELLQKVVEHVDITSYDARPIIDSMRKMSFSSRDTARAADIFNMALADKGCSTWLILAGSTSAGGCMHVYRDMVKNGMIDAVVATGASIVDMDFFEALGFKHYQAAGPVDDNVLRDNYIDRIYDTYIDEEELQACDHTILEICNKLEPRGYSSREFIWEMGKWLAEGNAKKEGSLIQTAYEEGVPIFCPAFVDSSAGFGLVKHQKEKIAEKKPYLMIDAVADFRELTDVKIAAGTTGLFMVGGGVPKNFAQDTVVCAEILGVEADMHKYAIQITVADVRDGACSSSTLKEAASWGKVSTTYEQMVFAEATTVVPLIASDAYWRKAWEGREKPRWNKLFGK
What are the official names of this protein?
Deoxyhypusine synthase-like protein.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: ARNC_SALNS
Sequence: MFDAAPIKKVSVVIPVYNEQESLPELIRRTTTACESLGKAWEILLIDDGSSDSSAELMVKASQEADSHIISILLNRNYGQHAAIMAGFSHVSGDLIITLDADLQNPPEEIPRLVAKADEGFDVVGTVRQNRQDSLFRKSASKIINLLIQRTTGKAMGDYGCMLRAYRRPIIDTMLRCHERSTFIPILANIFARRATEIPVHHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSLLGSVIAIGGFSLSVLLIVLRLALGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYNDVRARPRYFVQQVIYPESTSFTEESHQ
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.