PharMolix/UniProtQA huggingface dataset:
Protein: LECG_BOTPI
Sequence: NNCPGDWLPMNGLCYKIFNELKAWEDAEMFCRKYKPGCHLASIHIYGESLEIAEYISDYHKGQAEVWIGLWDKKKDFSWEWTDRSCTDYLSWDKNQPDHYENKEFCVELVSLTGYRLWEDQVCESKNAFLCQCKF
What is the function of this protein?
Galactose-binding protein which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  Calcium-dependent lectin.  Shows high hemagglutinating activity in the presence of human erythrocytes, which are agglutinated with a minimum hemagglutination concentration (MHC) of 2. 5-0. 35 ug/ml.  Causes indirect nephrotoxicity.  Causes reductions in perfusion pressures, renal vascular resistance, urinary flow, glomerular filtration rate, sodium, potassium and chloride tubular transport.  Its effects may be caused by the release of inflammatory mediators.
What are the official names of this protein?
C-type lectin BPL, CTL, Galactose-specific lectin.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NIPA1_HUMAN
Sequence: MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD
What is the function of this protein?
Acts as a Mg(2+) transporter.  Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
What are the official names of this protein?
Magnesium transporter NIPA1, Non-imprinted in Prader-Willi/Angelman syndrome region protein 1, Spastic paraplegia 6 protein.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Recruited to the cell membrane in response to low extracellular magnesium.
Protein: DUT_HHV6U
Sequence: MYSAISEKISETITLQRQTSSRYIEFFVFRNVDINELWTTDISEDKTHDVWPAVNEKSFKKFLENELTSYQRPIPLLGIPQNGTVSKTCKKEKQRETDCVNYERKRGNPVTFYPRHRAKRNANTDTCISEEPSILVSHHRNSKMDVFMDTNKITLVNRELIWVPHDQVRIVKLDISLYIPDGFFGVITGHSNDVFCECVTEIITDETDISVFLMNLSEHSLMLLPGDVEFSINFLPCYIPEPWEMINLSPPEFAIFHLKASREFIAKPNSYTIQYFDAMYVCADELKALMIPSKEIAKLGLLIETYIWNKDTIPSIKIFNSTRKTIYIPTGICIARIIFTCGHFCLSLMPERAINRLQVLDANSSFLFHYAASNNA
What is the function of this protein?
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: CASB_EQUAS
Sequence: REKEELNVSSETVESLSSNEPDSSSEESITHINKEKSQKFKHEGQQQREVEHQDKISRFVQPQPVVYPYAEPVPYAVVPQNILVLAQPPIVPFLQPEIMEVSQAKETILPKRKVMPFLKSPIVPFSERQILNPTNGENLRLPVHLIQPFMHQVPQSLLQTLMLPSQPVLSPPQSKVAPFPQPVVPYPQRDTPVQAFLLYQDPQLGLTGEFDPATQPIVPVHNPVIV
What is the function of this protein?
Important role in determination of the surface properties of the casein micelles.
What are the official names of this protein?
Beta-casein.
What is the protein family that this protein belongs to?
Belongs to the beta-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RISA_ECOLI
Sequence: MFTGIVQGTAKLVSIDEKPNFRTHVVELPDHMLDGLETGASVAHNGCCLTVTEINGNHVSFDLMKETLRITNLGDLKVGDWVNVERAAKFSDEIGGHLMSGHIMTTAEVAKILTSENNRQIWFKVQDSQLMKYILYKGFIGIDGISLTVGEVTPTRFCVHLIPETLERTTLGKKKLGARVNIEIDPQTQAVVDTVERVLAARENAMNQPGTEA
What is the function of this protein?
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
What are the official names of this protein?
Riboflavin synthase, RS.
Protein: IPK1_KLULA
Sequence: MTLLFVGRGNANVCYLLSGEVYRISLRHQKLSRNNAYVQDNFQFIDSKIRSLPMLADVVVSMRLEEVFVDTKWINVLKDENILIDDSHMQCIVMPLLHAKDSTCEQLDHFNQIYRCSLNDAITWEFKPKWLYQSSDYCRNCTHNSLKGRDIEYCFLHDPELIIETLFAGRQVPEEFLDDILQYLQSSDSITQRLYAAQRFVKDDLSTLMTLRDVTCFLTWSRNTRSVKATIIDVDQKPANKLRHWQSTESALASFPGKKKAHFNHQ
What is the function of this protein?
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
What are the official names of this protein?
Inositol-pentakisphosphate 2-kinase, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase.
What is the protein family that this protein belongs to?
Belongs to the IPK1 type 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_PARDP
Sequence: MSQISLTFPDGNARDYPAGVTAAEVAASIAPSLAKNAISASLDGQHIDLQWPIAASGRIAINTMKDSEPALELIRHDLAHIMARAVQELWPDVKVTIGPVRDQGWFYDFDRAEPFTPEDLGAIEQRMKQIIAARDPVRTEVWDRDRARAHYEAQGEPFKIELLDRIPEGEPIRMYWHGDWQDLCRGPHLQHTGQVPADAFKLTHVAGAYWLGDASRPMLQRIYGVAFRNRDDLKAHLTMLEEAAKRDHRKLGREMELFHFQEEAPGMVFWHPNGWSIYRELEAYMRRRLIRADYKEIKTPQVVDRILWEKSGHWEAYRENMFIVEVDEEGAKEKRINALKPMNCPCHVQVYNQGLKSYRDLPLRLAEFGSCHRYEPSGSMHGLMRVRGFVQDDAHIFCTEDQIEAECAGFIGLLSSVYKDLGFEKFDIKLSTRPDVRVGSDEIWDKAEAALKGAIEHLDLPYEVNPGDGAFYGPKLDFKLTDAIGREWQCGTFQCDFNLPQRLEAEYVGEDGAKHMPVMLHRAVLGSFERFIGILIENYSGKLPLWLAPRQVVVASIVSGADDYVHEVVAALRAAGLRAEADTRNEKINYKVREHSVGKVPVIMAVGLKEVEERSVSIRRLDRQGSESHGLESAIATLRAEATPPDLR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD1_CYPCA
Sequence: MADKIKDAKIVFVVGGPGSGKGTQCEKIVEKYGYTHLSSGDLLRAEVASGSERGKQLQAIMQKGELVPLDTVLDMIKDAMIAKADVSKGYLIDGYPREVKQGEEFEKKIGAPALLLYIDAKAETMVQRLMKRGQTSGRSDDNEETIKKRLDLYYKATEPVIAYYETRGIVRKINSELPVDEVFAIVVKAIDELK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Also displays broad nucleoside diphosphate kinase activity.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase isoenzyme 1, AK 1, ATP-AMP transphosphorylase 1, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, Myokinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATF2_MOUSE
Sequence: MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPPSQAQPSGS
What is the function of this protein?
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response.  Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').  In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death.  In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death.  The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF).  Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro.  In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.  Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity).
What are the official names of this protein?
Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, MXBP protein, cAMP response element-binding protein CRE-BP1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-34 is required for its nuclear localization and negatively regulates its mitochondrial localization. Colocalizes with the MRN complex in the IR-induced foci (IRIF) (By similarity).
Protein: NAGB_STAA8
Sequence: MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: HBB_AOTTR
Sequence: VHLTGEEKAAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSSPDAVMNNPKVKAHGKKVLGAFSDGLAHLDNLKGTFAQLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TPIS_CHLFF
Sequence: MERKSYVFGNWKMHKTAEEAKDFLSVFCPFVKEISPASIVGIAPSFTTLSACCESIKKMDSSIWLGAQNVHQDSSGAFTGEVSLPMLQEFHVNFVLLGHSECRHIFHEEDSTIALKVGAAARSGVVPVLCIGETLETRESGTTKDVLSNQLILGLAQLPETASVIIAYEPVWAIGTGKVASTADVQEVHAFCREVLSRIFSKEKSETISILYGGSVKADNAEGFARCPDVDGLLVGGASLDPQVFANVVGNFNL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTOR4_DANRE
Sequence: MTTALTQGLERIPDQLGYLVISEDGVLASAGELENDEHTAGVIMQMVRTACRFRLHGTAEPPFKRMSVMFEDYVYAVTISGQKVFVVKRQNNQREPVIV
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR4, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR4 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: GCH1_PORG3
Sequence: MTEIEKEEACSRLQQHYAQVLSLLGEDPKREGLLKTPLRVAKAMQFLTKGYNEDPEAILRAAMFEEDYQQMVIVKDIDFFSMCEHHMLPFFGKAHVGYIPNRYITGLSKLPRVVDVFARRLQVQERLTTQIKECIQNTLNPLGVIVVIEAQHMCMQMRGVEKQNSLTTTSDFTGAFEESTTREEFLNLIGRRR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: FOLD_THEMA
Sequence: MWIDCKTIARSIEERTKERVEKLGFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEIMNVSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVDGKLQGDVDPSVEEIARVTPVPGGVGQVTTALLFEHVVRAAERQRK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: KAD_BACC0
Sequence: MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_CLOK1
Sequence: MSLVPVVVEQTNRGERSYDIYSRLLKDRIVMLSEEVNDVTASLIVAQLLFLEAENPDKDIYFYINSPGGSITAGMAIYDTMQYIKSDVSTICIGMAASMGAFLLAAGEKGKRFALPNSEIMIHQPLGGFQGQATDIGIHADRILRIKKKLNAIISERTGQSIEKVEKDTERDNFMTAEEAKEYGLIDEVFTKKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP70_BRUMA
Sequence: MSKNAIGIDLGTTYSCVGVFMHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDANRLIGRKFDDGSVQSDMKHWPFKVVNAGGGKPKVQVEYKGETKTFTPEEISSMVLVKMKETAEAFLGHAVKDAVITVPAYFNDSQRQATKDSGAIAGLNVLRIINEPTAAAIAYGLDKKGHGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGEDFDNRMVNHFVAEFKRNDKKDLASNPRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTNITRARFEELCADLFRSTMDPVEKALRDAKMDKAQVHDIVLVGGSTRIPKVQKLLSDFFSGKELNKSINPDEAVAYGAAVQAAILSGDKSEAVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKTSETFTTYSDNQPGVLIQVYEGERALTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAQDKSTGKQNKITITNDKGRLSKDEIERMVQEAEKYKADDEAQKDRIAAKNALESYAFNMKQTIEDEKLKDKISEEDKKKIQEKCDETVRWLDGNQTAEKDEFEHRQKELESVCNPIITKLYQSAGGMPGGMPGGMPGGAPGAGSTGGGPTIEEVD
What are the official names of this protein?
Heat shock 70 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: GSTT1_CHICK
Sequence: MGLELYLDLLSQPCRSIYIFARTNNIPFEFKHVELFKDSVLGKKPAAASGAERPRTGPSNSEGDGKISLLKKVPVLKDGDFTLAECTAILLYLSRKYNTPDHWYPSDIKKRAQVDEYLSWHHANIRANAPKTMWIKVLIPLFTGQPQPSEKLQEVMEGLSTSLKQFEERFLQDKAFIIGSEISLADLVAIVELMQPVGVGCDIFEDRPRLMEWRRRVEEAVGKELFFQAHEMILNIKELSNIQIDPQLKEHLAPVLMKMLK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase theta-1, GST class-theta, GST-CL1.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK22_GRATE
Sequence: MTNKTTKIQATGKYVRLSTAKTRRVLNQIKGKKYQEAILILEFMTYKPCKIIKKILESAGNNALNLKYEKQNLIIKQAFANDGPKLKRFQPRAQGRAFRIQKPTCHITINLSIN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SYDP_SHEB2
Sequence: MSCLPALDKFLQNYHQAYLTSLGELPRYYPQGEASVCIQGEFHADLDQAVSWQPVKREVEGSFANVEHALELTLWPEINHFYGQYFSAPLLFDSEWGTGELLQVWNEDDFTCLQQNLIGHLMMKKKLKQPPTWFIGLLDEGDKMLTINNSDGSVWIELPGEIPTQQLSPSLAEFIGALSPRIAPPVKHEELPMPALEHPGIFASFKRMWQNLFGKR
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: RLMN_SALDC
Sequence: MSEQIVTPESSTPVVLNNETKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDTIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEVIDIKAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_BURM9
Sequence: MAVQQNKKSPSKRGMHRSHDFLTTSPLAVEPSTGEVHLRHHISPNGYYRGKKVVKTKND
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: COAX_MYCPA
Sequence: MLLAIDVRNTHTVVGLISGSKEHAKVVQQWRIRTESEITADELALTIDGLIGDDSERLTGAAALSTVPSVLHEVRLMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAFHRFQSPAIVIDFGSSICVDVVSAKGEFLGGAIAPGLQVSSDAAAARSAALRRVELARPRSVIGKNTVECMQAGAVFGFAGLVDGLVGRIREDVPGFGGDDVAIVATGHTAPLLLPELDTVSHYDQHLTLHGLRLVFERNRDAQRGRLKTAR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_NITOC
Sequence: MPIVKAKPTSAGRRFVVQVTSLELYKGRPHPALTKKLSKSGGRNNQGRITVRHCGGGHKRLYRIIDFRRDKIDVLGRVKRIEYDPNRSAHIALINYSDGEKRYIIAPKAVKVGDIITSGREAPIRDGNCLPLRNIPVGTLVHCIELKPGKGAQIARSAGSSCQLVAREGDHAMLRLRSGEIRKVPLECRATIGEVGNDGHGLRSLGKAGAMRWRGKRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGVPTKGYKTRRNKRTGKFIVRRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DNAK_MYCPN
Sequence: MSTDNGLIIGIDLGTTNSCVSVMENGRPVVLENPEGKRTTPSIVSYKNNEIIVGDAAKRQMVTNPNTIVSIKRLMGTSNKVTVKNPDGSTKELTPEEVSAQILSYLKDYAEKKIGKTISRAVITVPAYFNDAERNATKTAGKIAGLNVERIINEPTAAALAYGIDKSNREMKVLVYDLGGGTFDVSLLDIAEGTFEVLATAGDNRLGGDDWDNKIIEFILAHIAQEHNGLNLSNDKMAMQRLKEAAERAKIELSAQLEAIISLPFLTVTEKGPVNVELKLTRAKFEEITKQLLERTRNPISDVLREAKIKPEEINEILLVGGSTRMPAVQKLVESMVPGHSPNRSINPDEVVAIGAAIQGGVLRGDVKDVLLLDVTPLTLSIETLGGVATPLIKRNTTIPVSKSQIFSTAQDNQESVDVVVCQGERPMARDNKSLGRFNLGGIQPAPKGKPQIEITFSLDANGILNVKAKDLTTQKENSITISDNGNLSEEEIQKMIRDAEANKERDNVIRERIELRNEGESIVSTIKEILQSPEAKDFPKEEKEKLDKITGGIDAAIKANDYTKLKAEIENFKKWREEMAKKYNPNGDQGQPAQ
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: YO82_BPP2
Sequence: MPDNVDFIQEQQAELLERQINAARVKHCGASALVCEECDAPIPAARRAAYPSATRCVSCQSVFEAKNKHYRRTA
What are the official names of this protein?
Uncharacterized 8.2 kDa protein in gpA 5'region, ORF3.
Protein: RNH_PROMT
Sequence: MSKEEKLAIAAATDGACSGNPGPGGWGALIRFQDGSEIEFGGNSPETTNNRMELQAALFILEKLKNIKFAPSLTIKTDSKYLIDGMDKWMPNWKKKGWKTASGKPVLNQDLWKALDHPELPKIKLQYVKGHSGEKDNDRVDAIAVAFSKGRKIQLKDFANN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_DICTD
Sequence: MGVILEGKPVAEKLEKEIKEKIQFYKSQGVIPTLCIVKVGKNAEAEAYAKSIEKFFSKIGINIERKNFNEEISLVDFKKIMKELEEDSAIHGVLILRPLPEELERGKAFQFLPTKKDVEGVTYENLGRLLVGEDSFHPCTPQAVLELLDFYQIPVEGKNVVVVGRSISVGKPLSLLLLNRNATITVCHSKTKNLVEFTKKAEILIVAIGKPYFVGKDMVGEGQVIIDVGTNVVDGKLVGDVNFEEVKDKVEYITPVPGGIGVITTRVLAMNLLKAVKKVEA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HEM3_DICNV
Sequence: MSTLRIATRKSPLALWQAEHVAQQLKQHYPELTVELVPIVTQGDILAHTPLSKIGGKNLFIKELEIAMQQNAADIAVHSMKDVGVTLPEGFVLAAILPRENPFDALVSNHYAHLNELPNGARVGTCSLRRKMQLAHYRPDLKLIDIRGNVHTRLQKLDSGAFDALILACAGLIRLQQNARIRQILPAEISLPAIGQGAIGVECRADSPFLAHIQTLNHFETAVCVQTERVVNQRLQGDCQVPIAVFATLSGKTMTLQSRIGTIDGQRMLAHQEICALEDAEKAGARCAEALIQQGAQDILHEYRK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.