PharMolix/UniProtQA huggingface dataset:
Protein: SYV_ALCBS
Sequence: MIMDKTYQPDRIEQSWYENWEQAGHFKPSGQGDPFCIMIPPPNVTGSLHMGHAFQDTIMDTLVRYRRMQGRNTLWQVGTDHAGIATQMVVERKLAGEGTNRHELGREKFLDKVWEWKRESGGTITRQLRRMGASVDWTRERFTMDDGLSNAVREVFVRLHKEGLIYRGKRLVNWDPALHTAISDLEVENVEEQGHMWHFRYPLSDGSGHLVVATTRPETMLGDTAVAVHPQDPRYKDMIGKSIRLPLADRNIPIIADDYVDPDFGSGCVKITPAHDFNDYEVGKRHDLPMINILTIDAALNDEVPEGYRGLDRVEARKKVVDDLDALGLLEKVDDHTLQVPRGDRSGVVIEPYLTDQWFVAVEELAKPAIAAVENGDIQFVPKNYENMYFSWMRDLQDWCISRQLWWGHRIPAWYDADGNVYVGRDEEEVRAENNLGDTPLSQDDDVLDTWFSSALWTFSTLGWPDDTDALRTFHPTDVLVTGFDIIFFWVARMIMMTLKFTDQVPFKKVYVHGLVRDNDGQKMSKSKGNVLDPLDMIDGITLDALIDKRTKGLMQPQKEKQITKRTNKDFPDGINPYGTDALRFTFLSLASTGRDIKWDMGRIEGYRNFCNKIWNAARYVMMNTEGEDCGIDTDSEVELSLADRWIISALQRAELEVSEALDSFRFDVASHAAYEFIWNEYCDWYLELSKPVLWGDEYSDAQKRGTRRTLVTVLEAILRMAHPFMPFITEEIWQKVGPLAGKASAAGKGEKTDTIMLQPFPASEPAKIDTNAETGAEWVKAVISAVRNIRGEMGIPLGKALPIYLHNGKDSDKALLDANRVFLCKLAKLESITWLTAEDSAPASATALVGDMEILVPMAGLIDKEAEIERLSKEIEKLRKEVGRAEGKLKNPKFVDKAPQAVVDKEKAKLDDYRSQLAKLEEQLEKIKYL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_ANAMM
Sequence: MIFNVLTIFPDMFPGPLGYSTVGNALRKGLWSLNVVDIRSFASDKHSTVDDKPYGGGPGMLMKADVLGRCIDSVLEAHPDTRLIYTSPKGKQFTQDMSRQIVHFGNITLLCGRFEGIDERVVDVYNFQEVSIGDYVISGGELAAMVVIDSCVRMVTGVIGNKDSLNRESFDCGLEYPQYTRPASWKGVSVPDVLLRGNHKETELWRCKMSRIITERRRPDLLKDCGGEEEGSSNE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_MYCCT
Sequence: MSSKATKTVKSKFDIINNQLRDDLIDFRSGDTIRVDVKIKEGDKFRIQSFEGLVIKTQGSGITYSVVVRKMSNGVFVERTFPLHSPIIDSVTLIKRGKVRRSRIYYIRKLSGKAARIKEIMPTKQAKEIK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: FIGL1_HUMAN
Sequence: MQTSSSRSVHLSEWQKNYFAITSGICTGPKADAYRAQILRIQYAWANSEISQVCATKLFKKYAEKYSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKWQSGLSINNVFKMSSVQKMMQAGKKFKDSLLEPALASVVIHKEATVFDLPKFSVCGSSQESDSLPNSAHDRDRTQDFPESNRLKLLQNAQPPMVTNTARTCPTFSAPVGESATAKFHVTPLFGNVKKENHSSAKENIGLNVFLSNQSCFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK
What is the function of this protein?
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR).  Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner.  May regulate osteoblast proliferation and differentiation (PubMed:23754376).  May play a role in the control of male meiosis dynamic (By similarity).
What are the official names of this protein?
Fidgetin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: IPYR_HALVD
Sequence: MVNLWEDMETGPNAPDEIYAVVECLKGERNKYEYDKDIPGVVLDRVLHSNVHYPSDYGFIPQTYYDDEDPFDVLVLVEDQTFPGCVIEARPVALMKMDDDGEQDDKVIAVPVEDPRYDHIEDLDDIPQQTLDEIDEFFATYKNLEAGKEVETLGWEDKQAAKDAIEHAMDLYEENFA
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions (By similarity) (PubMed:26546423).  The hydrolysis of PPi by inorganic pyrophosphatase releases a considerable amount of energy that can drive unfavorable biochemical transformations to completion (Probable).  Is not active on nucleoside triphosphates (ATP, TTP, GTP, or CTP) or nucleoside diphosphate (ADP) (PubMed:26546423).
What are the official names of this protein?
Inorganic pyrophosphatase, PPA, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_PROMH
Sequence: MSSKEQNVHEEQVSKEKEGMESVMNESQEQVKSEDAQAEFDAQAELVQALARVDELEKQLQQSQKTEREAMIRAQAEIENIRRRTQQDVEKAHKFALEKFSNELLPVLDNLERALSAADHENEQMQPMIEGLELTLKSFLDAVRKFGIEVVEEKNVAFNPEVHQAMTLIDSPEHEANHVVDVMQKGYTLNGRLLRPAMVVVSK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACNA_STAAW
Sequence: MAANFKEQSKKHFDLNGQSYTYYDLKAVEEQGITKVSNLPYSIRVLLESLLRQEDDFVITDDHIKALSQFGKDGNEGEVPFKPSRVILQDFTGVPAVVDLASLRKAMDDVGGDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYNAVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPGVQHLPLADRATIANMAPEYGATCGFFPVDDESLKYMKLTGRSDEHIALVKEYLKQNHMFFDVEKEDPNYTDVIELDLSTVEASLSGPKRPQDLIFLSDMKSSFENSVTAPAGNQGHGLDKSEFDKKAEINFKDGSKATMKTGDIAIAAITSCTNTSNPYVMLGAGLVAKKAVEKGLKVPEYVKTSLAPGSKVVTGYLRDAGLQPYLDDLGFNLVGYGCTTCIGNSGPLLPEIEKAIADEDLLVTSVLSGNRNFEGRIHPLVKANYLASPQLVVAYALAGTVDIDLQNEPIGKGNDGEDVYLKDIWPSIKEVSDTVDSVVTPELFIEEYNNVYNNNELWNEIDVTDQPLYDFDPNSTYIQNPSFFQGLSKEPGTIVPLNGLRVMGKFGDSVTTDHISPAGAIGKDTPAGKYLQDHQVPIREFNSYGSRRGNHEVMVRGTFANIRIKNQLAPGTEGGFTTYWPTNEVMPIFDAAMKYKEDGTGLVVLAGNDYGMGSSRDWAAKGTNLLGVKTVIAQSYERIHRSNLVMMGVLPLEFKKGESADSLGLDGTEEISVNIDENVQPHDYVKVTAKKQDGDLVEFDAMVRFDSLVEMDYYRHGGILQMVLRNKLAQ
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate.  Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate.  The apo form of AcnA functions as a RNA-binding regulatory protein.
What are the official names of this protein?
Aconitate hydratase A, ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: CCR4_ASPCL
Sequence: MNGGQAHQRFGMQIPKFQSQNHHPHHTQQPHHHTHHNQASHNINHQHQFSSGALASATPHFTPSHMQNGAHTNVDEDIDDSMNEHWQQQLQLAAESRQANSPHYHARSVAQQAKGIQIAPSQPDTQEQGSDGQNGVGKTKAVSRQGWHALDFGGQGLRALSTSLFNYVFLEKLYLNHNKLKSLPPTIGHLRKLSHLDLSGNDLTELPDEIGMLTNLRKLYLFDNNIRTLPYEMGYLYRLDTLGIEGNPLNDVLKSHIMKEGTKALIKYLKEEMPVHLPPPDRDWVVLDETASASTEKITVLSYNTLCDSSATQSHYGYAPARVLSWEFRRELILSELRSHGSDIVCLQEIDQGSYNEYFREQLAYNDYKGVYWPRGRAMGMQEEDAKGVDGCATFFKGSKFILLDKQLINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVVFLENRQTGSRFIVVNAHLYWDPAFKDVKLIQTAILMEEITKLSETYAKWPACTDKAAFRFSKEEGQTEAPPPEEPAPSVQYSSGDQIPLLMCGDLNSSPGSAAYNLIAHGRLDEEHPDLEKRLYGNLSKVGMTHPFKLKSAYGSIGELPFTNYTPDFKDILDYIWYSSNSLHVSALLGEVDKDYLQKVPGFPNYHFPSDHIALFAEFTVKGKKGKVVEADFGPQRN
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YHDP_BACSU
Sequence: MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKAAIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVISFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSARLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKEIMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISGEVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDIIEEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWFLTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA
What are the official names of this protein?
UPF0053 protein YhdP.
What is the protein family that this protein belongs to?
Belongs to the UPF0053 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP37C_MOUSE
Sequence: MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRPRALPELAGDVPPKRPPPPRPVPQATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRSGPPQPGYPTAPTSTSGPGYPLVGGRTPGPGYPQQSPYLPSGNKPPYPTQPQLPGFPGQPQPPVPPQPPYPPGTTPSYGFHPPGPAWPRY
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.  May be involved in cell growth and differentiation (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 37C, ESCRT-I complex subunit VPS37C.
What is the protein family that this protein belongs to?
Belongs to the VPS37 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes.
Protein: DPO3_STRP8
Sequence: MSDLFAKLMDQIEMPLDMRRSSAFSSADIIEVKVHSVSRLWEFHFAFAAVLPIATYRELHDRLIRTFEAADIKVTFDIQAAQVDYSDDLLQAYYQEAFEHAPCNSASFKSSFSKLKVTYEDDKLIIAAPRFVNNDHFRNNHLPNLVKQFEAFGFGTLTIDMVSDQEMTEHLTKDFVSSRQALVKKAVQDNLEAQKSLEAMMPPVEEATPAPKFDYKERAAKRQAGFEKATITPMIEIETEENRIVFEGMVFDVERKTTRTGRHIINFKMTDYTSSFALQKWAKDDEELRKFDMIAKGAWLRVQGNIETNPFTKSLTMNVQQVKEIVHHDRKDLMPEGQKRVELHAHTNMSTMDALPTVESLIDTAAKWGHKAVAITDHANVQSFPHGYHRARKAGIKAIFGLEANIVEDKVPISYDPVDMDLHEATYVVFDVETTGLSAMNNDLIQIAASKMFKGNIVEQFDEFIDPGHPLSAFTTELTGITDKHLQGAKPLVTVLKAFQDFCKDSILVAHNASFDVGFMNANYERHNLPKITQPVIDTLEFARNLYPEYKRHGLGPLTKRFQVSLDHHHMANYDAEATGRLLFIFLRDAREKHGIKNLLQLNTDLVAEDSYKKARIKHATIYVQNQVGLKNMFKLVSLSNIKYFEGVPRIPRTVLDAHREGLLLGTACSDGEVFDAVLTKGIDAAVDLAKYYDFIEIMPPAIYQPLVVRELIKDQAGIEQVIRDLIEVGKRAKKPVLATGNVHYLEPEEEIYREIIVRSLGQGAMINRTIGRGEGAQPAPLPKAHFRTTNEMLDEFAFLGKDLAYQVVVQNTQDFADRIEEVEVVKGDLYTPYIDKAEETVAELTYQKAFEIYGNPLPDIIDLRIEKELTSILGNGFAVIYLASQMLVNRSNERGYLVGSRGSVGSSFVATMIGITEVNPMPPHYVCPSCQHSEFITDGSVGSGYDLPNKPCPKCGTPYQKDGQDIPFETFLGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGDEYAFRAGTVGTVAEKTAYGFVKGYERDYGKFYRDAEVDRLAAGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTASWQTTHFNFHDIDENVLKLDILGHDDPTMIRKLQDLSGIDPITIPADDPGVMALFSGTEILGVTPEQIGTPTGMLGIPEFGTNFVRGMVNETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKEGIATLKTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIDAMRENNVPDWYIESCGKIKYMFPKAHAAAYVLMALRVAYFKVHHPIMYYCAYFSIRAKAFELKTMSGGLDAVKARMEDITIKRKNNEATNVENDLFTTLEIVNEMLERGFKFGKLDLYKSDAIEFQIKGDTLIPPFIALEGLGENVAKQIVKARQEGEFLSKMELRKRGGASSTLVEKMDEMGILGNMPEDNQLSLFDDFF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSBA_RALSO
Sequence: MAVTSSSSSQPPAASQPGHFKRLWAYLRPELSSFILAMVAMGVVAATEGIIPKVVKDLLDQGFGGEYAGKLWRVPAMLVGIAVVRGVAQFGATYFLSLVSNKVLLNLRMKMFERLLQAPAAFYQRNTAASLINAVIFEVNQVLQVLTGVFITLVRDSMTVLALLIFLFYTNWRLTLVVAVILPVIGFLMSRINRRLRSLNREHQNLTNEAAYVVEEAAGGYKVVKLHGGEAYESRRFNAMTNRLRGYAMRMAVAGGLNQPVTQFLAALALSVILAIAMVQAQANQTTVGGFTGFVMAMLLLISPLKHLTDVNQPMQRGLTAAEFIFGLIDTPIEPQDGGKHIDRARGDLRFEHVTFRYGPDGRAALDSIDLHVKAGEIVALVGPSGSGKTTLVNLLPRFFEPTSGRIVLDGDALADLSLQDLRRQIAFVSQDVVLFNDTIAANVAYGARDASEIDMARVRRALEAAYLTDVVDNLPDGVDTNIGDNGSKLSGGQRQRLAIARAVYKDAPILILDEATSALDSESERQVQAALEALMQGRTTLVIAHRLSTIENADRIVVLEHGQIVEAGTHRELLDRDGLYAGLHRIQFATQ
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTBC1_VITVI
Sequence: MAAAALNGLKMAATSQAYLESMPVNDTRKLLSDLCRHFYGLGWVSGTGGSITIKVHDESIPKPQQLIVMSPSGVQKERMVPEDMYVLSPSGCFLSSPSPKPYPNKPPKCSDCAPLFMKAYLMRNAGAVIHSHGMESCIVTMIDPLSKEFRITHMEMIKGIQGHGYYDELVVPIIENTAHERELTDALAEAIEAYPKTTAVLVRNHGIYIWGDSWIHAKTQAECYHYLFDAAIKLYQLGLDWSTPDHGPIKKYGGKTNMSVKAGTVNSNHETEPSRRCIVLDIEGTTTPISFVTDVLFPFARNNVSRHLAATYETDETQDDIKLLRTQVQSDLEQGIVGAVPIPPDDAGKEEVIAALVANVEAMIKADRKITALKQLQGHIWRTGFQNNELEGVVFEDVPEALQKWHASGIKVYIYSSGSRLAQRLLFGYTNYGDLRKYLCGFFDTTVGNKRETKSYVEITESVGVDKPSEILFVTDVYQEAVAAKAAGLEVIISIRPGNGPLPDNHGFKTITSFSDI
What are the official names of this protein?
Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: IDI2_CROS8
Sequence: MKDKELSQRKNDHLDIVLHPERAKQTIRTGFEQWRFEHCALPELALDDIDLSTRLFGRVMKAPLLISSMTGGARRASDINRHLAEAAQTLGLAMGVGSQRVALESEDNWGLTGELRRYAPDIPLLANLGAAQIGSLQGLDYARRAVEMVEADALIIHLNPLQEALQTGGDRDWRGVLAAIKRVVNALSVPVVVKEVGAGLSVPVARQLAEAGVTMLDVAGAGGTSWAAVEGERAASDHARSVAMAFADWGIPTAQALRQIHQAFPSMPLIASGGIRDGIDTAKALAMGASLVGQAAAVLGSATTSTSAVLDHFAVVIEQLRVACFCTGSASLSALREARLARVGDEE
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O162_CONAE
Sequence: MKLTCMMIVAVLFLTAWTSVTAVNTRGELENLFLRASHEMNSEASKLDKKVCVDGGTFCGFPKIGGPCCSGWCIFVCL
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like ArMKLT1-011, Conotoxin ArMKLT1-0131.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FM523_PICST
Sequence: MAGGAFVLGSTGMCGLQMLKAVEKSASFDKVVTIGRRPPSLESPKLKAIVEKDSEKWGEIVEKEAKGFKVLMSGLSTTRGAAGSDEGFYNIDYTLNYAAAKAAKNAGVETYVLISGSFADANSRFLYIKTKGKLEDDVRALKFKRTIIFRPGLILGDREKKKSAGEEFIVSILKYTYGNFLSNITNPIYAKHIGEIATTLASEPIPEDQTEPTVRIIGARELSALGKALP
What are the official names of this protein?
Protein FMP52-3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FMP52 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein.
Protein: RNPA_THESC
Sequence: MDEKDLATQPEEAGQDPRLPGPHEDPRRQEGVEAEKAEGPLAPHPQGERLSQPPPAAGGKLLSLKGDRAFQRLRQGRMGRGRFLNVKWLPASELRVGIVVSKKVGKAVVRNRIKRRLREILRRLHLPKAHLLVIASPEAREATYAELFQDLIRALKKSGLIQ
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: AATA_EMENI
Sequence: MLHVTCQGTPSEIGYHHGSAAKGEIAKAIDFATGLIHGKTKKTQAELEQLLRELEQVMKQRWPRYYEEICGIAKGAEREVSEIVMLNTRTEFAYGLVEARDGCTTVYCKTPNGALQGQNWDFFTATKENLIQLTICQPGLPTIKMITEAGIIGKVGFNSAGVAVNYNALHLHGLRPTGLPSHLALRMALESTSPSEAYEKIVSQGGMAASAFIMVGNAHEAYGLEFSPISLCKQVADTNGRIVHTNHCLLNHGPSAQELNPLPDSWSRHGRMEHLLSGFDGTKEAFAKLWEDEDNYPLSICRAYKEGKSRGSTLFNIVFDHVGRKATVRLGRPNNPDETFVMTFSNLDTKSAIQANI
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic (PubMed:2120195, PubMed:2110531).  AatA catalyzes the exchange of the alpha-aminoadipyl side chain of isopenicillin N for phenylacetic acid to yield penicillin (PubMed:2120195, PubMed:2110531).  This step occurs in the peroxisomal matrix and the penM and paaT transporters are involved in the isopenicillin N and phenylacetic acid import into the peroxisome, respectively (By similarity).  The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA.  The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus.  Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase penDE to yield penicillin in the peroxisomal matrix (By similarity).
What are the official names of this protein?
Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form, Isopenicillin-N N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C45 family.
What are the subcellular locations of this protein?
Peroxisome matrix. Note=The unprocessed preprotein is translocated inside peroxisomes and regulates its self-processing.
Protein: TSAC_ACIBS
Sequence: MITTSVTEAAECLQQGQVLAYPTEAVWGLGCDPFNEQAFQKILELKQRPIEKGVILLAGHISQVEHLLTSLPQTTQQEIIDCWTNHQPSERATTWLLPADQHIPSWIKGEHPLVAVRVTTHPLCVALCNAFHGFIVSTSANPSGQEPAHSLQDACQYFGSQLNYLNGDLGQSQQPSRIINALTGEVIRP
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_YERPN
Sequence: MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGRSEAKAAGKLLKDEGFTFDFAYTSVLKRAIHTLWNILDELDQAWLPTEKTWKLNERHYGALQGLNKSETAEKYGDEQVKQWRRGFAITPPALEKSDERFPGHDPRYAKLTDAELPTTESLALTIERVIPYWNDVIKPRIASGERVIIAAHGNSLRALVKYLDDLGEDEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: DXS_BACC4
Sequence: MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPQDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSAVVSETVLKLARADERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVLMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLGVHMDEELKAIPIGTWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: COAD_WOLPP
Sequence: MNISNKIGIYPGTFDPITFGHLDIIKRACKLVDKLIIGVAENVNKHTNFDIRLRTSMAKNEVKGAGIDADIISFNGLLVKFAKEQNASVIIRGLRAVSDFDYEFQMSWVNYKLFPEIETIFLPASEDTQFISSSFVKEIARLGGDVSNFVSKSVQSELINLNRVENGE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_PEDPA
Sequence: MDNRPIGFMDSGVGGLTVVKTAQKLLPNEEIIFIGDEARMPYGPRPTAEVVEFSRQMASFLMTKNIKALVIACNTATNAALAVLQAELPIPVIGVILPGAIAANRQTKNQKIGVIATLGTIKSEAYPKALAEINTKLRAYPVACQEFVEIAEKNELHTTAAQKVMNEKLAEFRQDQIDTLILGCTHFPLLEEGIQAAVGPDVTLVDPGVETVHQLIEILTKQALQHAEGPKAQDQYYSTGNIKNFEEIARTFLNQDLRVEEVKID
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.