PharMolix/UniProtQA huggingface dataset:
Protein: VEMP_IBVP3
Sequence: MMNLLNKSLEENGSVLTAFYIFVAFVALYLLGRALQAFVQAADACCLFWYTWVVVPGAKGTTFVYKHTYGKKLNKPELETVIVNEFPKNGWKQ
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the gammacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: TRPB2_CHLCV
Sequence: MKHPYPFGGQFMPEILMAPVQDLSNSWKSLQNHSDFKNELDSVLKNYAGRPTPLTEIKNFAKAIHGPRIFLKREDLLHTGAHKINNALGQCLLAKHLGKTRIIAETGAGQHGVATATACGCLGLECVIYMGAKDIERQKPNVDKMNLLGAEVISVNQGAQTLKDAVNEALRDWSKNYESTHYCLGSALGPSPYPEMVRNFQSVISLEVKSQLQEIGFSPDLLIACVGGGSNAIGFFHHFIPDTRVKLVGVEAGGLGIESGHHAARFATGRPGVLHGFYSYLLQDNEGQVLPTHSISAGLDYPAVGPDHAVLYESGRASYTVATDKAALEAFFLLSRLEGIIPALESSHALAELINIAPTLPKESVVVVNLSGRGDKDLEQITNLIKAGNNE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 2.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RNPA_HAEI8
Sequence: MVKLNFSRELRLLTPIQFKNVFEQPFRASTPEITILARKNNLEHPRLGLTVAKKHLKRAHERNRIKRLVRESFRLSQHRLPAYDFVFVAKNGIGKLDNSAFAQILEKLWQRHIRLAQKS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RS3A_SCHJY
Sequence: MAVGKNKRLSKGKKGIKKRVVDPFSRKDWYDIKAPSFFEVKNVGKTLVNRTAGLKNANDALKGRIVEVSLADLQKDEEHSFRKVKLRVDDVQGKACLTTFNGMSMTSDKLRSLVRKWQTTIEADQTIKTTDGYVCRIFVIGFTRRRYNQIKKTTYAQSSQIRAIRQKMFQVIQNQATGCSMRELVQKLIPEIIGREIEKATGGIFPLQNVFVRKVKILKSPKLDAQKLLEQHGEAQDVGTKVIKDVAPLASV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XNI_SALTI
Sequence: MAAHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIIHSQPTHAVAVFDDDARSSGWRHQRLPDYKAGRPPMPDDLHNEMPALRAAFEQRGVRCWASDGNEADDLAATLALKVTEAGHQATIVSTDKGYCQLLSPGLRIRDYFQKRWLDAPFIEKEFGVLPRQLPDYWGLAGISSSKVPGVAGIGPKSATQLLVQFQNLEGIYAHLDEVPEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLVR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: MSHC_FRASN
Sequence: MPCSSPACPACPAAGPAPVTLTRMQAWPFPQLPKLPGQGRDLRVLDTAHGGVRTLDLGPTVRLYACGITPYDATHLGHAFTYLTYDLVQRVLRDAGHEVRYVQNVTDVDDPLLERATRDGIDWRDLARREIDLFRADMTALRILPPDHYVGVVEAVGLIVDMVSQLVERGAAYSVDGDLYFSVAAAPDFGQVAHLDPAQMLVSCAEHGGDPGRPGKKDPLDPLLWRAERPGEPSWPSPFGPGRPGWHVECSAIARHYLGATIDIQGGGSDLAFPHHECSAAHAEVANGARPFARAYVHTALVSLDGHKMSKSRGNLEFVSRLLARGADPAAIRLALLQHHHTVEWEWTAAAMPAAAERLDRWRAAVALPSGPDFRPVLAEVRDRLADDLDAPGALAAVDAWAAAALAAGSGGSGEADDQAPATVRDTVDSLLGVDLGPVLPRGT
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: ATPA_ECO5E
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPLDHDGFSAVEAIAPGVIERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSFEAALLAYVDRDHAPLMQEINQTGGYNDEIEGKLKGILDSFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y5526_DICDI
Sequence: MNKKLSIIFLIFALIASVLCSAEDPHLFHSSSTTTTTSSSGGTSGTDSSINTGSSYSGSGSGSGSTGGSGSGSGSGTAKWK
What are the official names of this protein?
Uncharacterized protein DDB_G0283449.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31_MYCGI
Sequence: MKSGIHPDYVETTVLCGCGASFTTRSTKKSGNITVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: GUAAA_METMP
Sequence: MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATNCENIALNSELPVLGICLGHQLISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFTAWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGVQFHPEVSHTEYGDIILKNFCKKCGFGFEE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: RL2_CLOAB
Sequence: MAVRGFKPTSPARRQMTVSTFEEITTDVPEKSLLVSLNNKAGRNNNGKITVRHRGGGNRNKYRLIDFKRNKDGVPAKVTTIEYDPNRSAYIALVVYADGEKRYIIAPTKLSVGDTVVSGPDADIKIGNALPIKNIPVGTVIHNVELAAGKGAQLVRAAGSSAQLMAKEGNYAQLRLPSGEMRYVRIECRATIGTVSNLTHDIVNIGKAGRKRHMGIRPTVRGSVMNPNDHPHGGGEGKSPVGRPGPVTPWGKPALGYKTRKNKKYSDKLIVKRRNDK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DNAJ_LEGPL
Sequence: MEQRDYYELLEVSRNASDAEIKKAYRRLAMKYHPDRNPGDTSAEEKFKEIQKAYNILSDKQKRAAYDQFGHAGVDPSMGGGPGGFGGFGGFGDVFEDIFENIFSGGRGQGRQSRGQRGADLQFNVQLTLEEAAIGKEVEITVPRHGTCTVCEGSGAKKGTSPKTCETCQGMGQVRIQQGFFSIQQTCPTCHGEGKIISDPCASCHGQGRVRESKKINVKIPAGVDNGDRVRLSGEGEAGVHGGGSGDLYVQISLKKHAIFERHENDLHCEVPISFATAALGGSIEVPTLEGRVTLKIPAETQTGKVFRLRSKGMKSVRGYGQGDLLCKVVVETPVNLSREQKELLNKLQDSLENAKGTHSPKTSSWFAGVKKFFEDMKF
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_MYCGI
Sequence: MIILAIESSCDETGVGIAELGDDGSVTLLADEVASSVDEHARFGGVVPEIASRAHLEALGPTMRRALATAGVDKPDVVAATIGPGLAGALLVGVAAAKAYAAAWQVPFYAVNHLGGHLAADVFDHGPLPESIGLLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKIARLLGLGYPGGRVLDELAREGDPKAITFPRGMTGPRDEPYAFSFSGLKTAVARYVESHPEASQADVAAGFQEAVADVLTAKAVRAAGDLGVSTLLIAGGVAANSRLRELAAQRCEAAGMTLRIPRPRLCTDNGAMIASFAAHLIAAGAAPSPLDAASDPGLPVVQGQVA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_GEOMG
Sequence: MNTIDMLELEQMKKNIPPFKPGDTVKVHVKIVEGDKSRIQAFQGVVIARQNGGIRESFTVRKISNGIGVERVFPLHSPSLDAIEVITRGHVRRAKLYYLRKLRGKAARIREKKYVAAH
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SG1C1_HUMAN
Sequence: MKGSRALLLVALTLFCICRMATGEDNDEFFMDFLQTLLVGTPEELYEGTLGKYNVNEDAKAAMTELKSCIDGLQPMHKAELVKLLVQVLGSQDGA
What are the official names of this protein?
Secretoglobin family 1C member 1, Secretoglobin RYD5.
What is the protein family that this protein belongs to?
Belongs to the secretoglobin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOD_BACCR
Sequence: MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQIIPYTDRMDYLSAMTNNYVICHAVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLDIGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVKWDAPDGWIEKVEEFVPYMREQLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDRFDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKDGAVLAKVPKIIKAPKGEAFVRIESPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIVLGEVDG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: STEL5_DROME
Sequence: MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYLRGDFGSCPNISCYRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSMLPNLTSPLDDPRT
What is the function of this protein?
Unknown.  In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
What are the official names of this protein?
Stellate protein CG33243.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
Protein: NSP2_ROTSP
Sequence: MAELACFCYPHLENDSYKFIPFNNLAIKAMLTAKVDKKDMDKFYDSIIYGIAPPPQFKKRYNTNDNSRGMNFETIMFTKVAMLICEALNSLKVTQANVSNVLSRVVSIRHLENLVIRKENPQDILFHSKDLLLKSTLIAIGQSKEIETTITAEGGEIVFQNAAFTMWKLTYLEHQLMPILDQNFIEYKVTLNEDKPISDVHVKELVAELRWQYNKFAVITHGKGHYRIVKYSSVANHADRVYATFKSNVKTGVNNDFNLLDQRIIWQNWYAFTSTMKQGNTLDVCKRLLFQKMKPEKNPFKGLSTDRKMDEVSQVGV
What is the function of this protein?
Participates in replication and packaging of the viral genome.  Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities.  The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures.  The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.
What are the official names of this protein?
Non-structural protein 2, NSP2, NCVP3, Non-structural RNA-binding protein 35, NS35.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP2 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RR2_GOSHI
Sequence: MARRYWNINLEEMLEAGVHFGHGTRKWNPRMAPYISAKRKGIHITNLTRTARFLSEACDLVFDAASKGKQFLIVGTKNKAADSVARAAIRARCHYVNKKWLGGMLTNWPTTETRLHKFRDLRTEQKTGGLNRLPKRDAAMLKRQLSRLQTYLGGIKYMTRLPDIVIIVDQQEEYTALRECITLGIPTICLIDTNSDPDLADISIPANDDAIASIRLILNKLVVAICEGRSSYIRNP
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ILVD_HALH5
Sequence: MRSDMIKKGIDRAPHRSLLRAAGVKEEEMDKPFIGVCNSYIDIIPGHMHLNKFAEVAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSREIICDAAETVINAHWFDGVFFIPNCDKITPGMLMASVRTNVPSVFVSGGPMEAGRTKDGKNLSLASVFEGVGAFSSGKMTREELLEIEQTACPTCGSCSGMFTANSMNSLMEMLGMALPGNGTIVATSEARHQLIKDAAKHLMNLIEKDIRPRDIITKETIDDAFALDMAMGGSTNTVLHTLAIANEAEIEYDLNRINEVAERVPYLCKISPASDYSMDDVHHAGGVAAIIKELCEIDGAIHPDRITITGKSIYENVKDAEITDDVVIRRKDNPYSPVGGLSILFGNLAPNGAVIKVGAVDPSIQIFEGEAIVYNSQEEAQQGINNGDVREGHVVVIRYEGPKGGPGMPEMLAPTSAIIGRGLGTKVALITDGRFSGASRGISIGHISPEAAEGGPIAFIENGDKIRIDLPNRTIEWLVSDEEIAKRQEGWTEPEPKVKKGYLARYSKLVTSANTGGVMKI
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CRU2_ARATH
Sequence: MGRVSSIISFSLTLLILFNGYTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLFLPTFLNAGKLTFVVHGRGLMGRVIPGCAETFMESPVFGEGQGQGQSQGFRDMHQKVEHLRCGDTIATPSGVAQWFYNNGNEPLILVAAADLASNQNQLDRNLRPFLIAGNNPQGQEWLQGRKQQKQNNIFNGFAPEILAQAFKINVETAQQLQNQQDNRGNIVKVNGPFGVIRPPLRRGEGGQQPHEIANGLEETLCTMRCTENLDDPSDADVYKPSLGYISTLNSYNLPILRLLRLSALRGSIRKNAMVLPQWNVNANAALYVTNGKAHIQMVNDNGERVFDQEISSGQLLVVPQGFSVMKHAIGEQFEWIEFKTNENAQVNTLAGRTSVMRGLPLEVITNGYQISPEEAKRVKFSTIETTLTHSSPMSYGRPRA
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
12S seed storage protein CRB, Cruciferin 2, AtCRU2, Cruciferin B, Legumin-type globulin storage protein CRU2.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
What are the subcellular locations of this protein?
Protein storage vacuole.
Protein: TATB_HYPNA
Sequence: MLPGIGFSELLLIGLAALIIIGPKDLPMMMRTLGQLMGKGRRMAREFQAAFDDIARQSELDELKKEIQDLRQSNTFKSAQDDLAAYEADVNSAVMREHPVSPPPPATPPAPPAELPPEAAPHADSQNAPPEADPAKGDRT
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: H2A_DROME
Sequence: MSGRGKGGKVKGKAKSRSNRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RLUC_YERPE
Sequence: MKTNNPVVQLITISADEAGQRIDNFLLAKLKGVPKSMIYRIVRKGEVRVNKGRIKPEYKLADGDVVRVPPVRVAEREEVQVSAKLDKVAALADCILFEDDYLLVLNKPSGTAVHGGSGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLLVAKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSEGKPSETRFKIEERFEHATLVKASPVTGRTHQIRVHALHAGHPIAFDDRYGYREFDQQLQGTGLHRLFLHAAALRFEHPNTGETMRIEAPLDNQLRHCLLALRKNATVK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase C, 23S rRNA pseudouridine(955/2504/2580) synthase, rRNA pseudouridylate synthase C, rRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: DMSB_HALSA
Sequence: MTNYGLVIDQERCIGCQSCSLTCKQENNVPMGQFWNRVLTQGGDHVDTPSGDYPEGGDGGTLEMTYQPTACQHCENAPCVKVCPVNATYTRDDGIVEIDYDKCMGCRYCMAACPYNARVFNWDEPEHRPEDGTGDVAERPQGVVEKCTFCSHRVEDGLDPACVVNCPADARIFGDLDDDDSTVSKYIAEYDTHQLLDEKGTDPSTYYINGEMSPGRPWKSKKLESELDDDEAAKAARRRSGSVENGYDVTPHVPAETAGGDD
What is the function of this protein?
Dimethyl sulfoxide (DMSO) reductase catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS) during anaerobic respiration; it can also use trimethylamine N-oxide (TMAO) as terminal electron acceptor.  Subunit B is proposed to be involved in electron transfer.
What are the official names of this protein?
Putative dimethyl sulfoxide reductase iron-sulfur subunit B, DMSO reductase subunit B.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TOR1A_HUMAN
Sequence: MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREALQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRVAEEMTFFPKEERVFSDKGCKTVFTKLDYYYDD
What is the function of this protein?
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates.  Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN).  In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity.  Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission.  In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding.  May have a redundant function with TOR1B in non-neural tissues.
What are the official names of this protein?
Torsin-1A, Dystonia 1 protein, Torsin ATPase-1A, Torsin family 1 member A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2.
Protein: ATP6_SALNS
Sequence: MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIELIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILILFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FOXA1_XENTR
Sequence: MLGIVKMEGHETTDWSNYYQDTQEAYSSVPVSNMTQGLASMNTYMTMNPMSSSSNMTAGSFNMSYANSGLGAGLSPSGMSGMGAGSASAMNGMGSGVSSMGTALSPSSMNAMSAQQASINSLSYSGMNPGMSPMAYGPSNMNRTRDTKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFLYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQQGGKGSQDGRKDVSGPSSPLHRVHGKSSQMDSSSSMSNPSSSPQSLEHNGSNGEMKPQVAAGPSPLSSHQNHSTHSLAHETHIHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQQYSSYSGGLPGMPLGSPSMAGRGSIEPSALEPTYYQGVYSRPVLNTS
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Forkhead box protein A1, FoxA1, tFoxA1.
What are the subcellular locations of this protein?
Nucleus.