Protein: FANCM_CHICK
Sequence: MSGGRQRTLPEAWRRAAGPALQAGRDADGNDDDDDELLAAAAAELDPDPNPNVDPNPGPGPEAAAGGFCAAAGALWIYPTNRPERPYQLRMARAALFANTLLCLPTGLGKTFVAAVVMYNFYRWFPSGKVLFLAPTKALVAQQMEACAQLMGIPGRDMAEMTGGTQALSRRELWASRRVFFLTPQIMVNDLSRGTCPAVEVKCLVVDEAHKALGNHAYCQVVKELSRYTTQFRVLALTATPGSDTKAVQQVVSNLLIAQIELCSEDSPEIQPYSHERQVEKIVVPLGEELGGIQRAYIHVLETFAGRLIKLGVLARRDVPSLTKYQIILARDQYRKNPSPQNVGMQPGIIEGDFALCISLYHGYELLQQMGVRSLFIYLCGIMDGSKGLTRTKNELGRNEDFMRLYQQLTDMFSDTCQTSANGNLHKSRTVSENKKEFIYSHPKLKKLEEIVIEHFKSRKMGCSDQTTSGGTCVDTRVMIFSSFRDSVQEIAEMLSRFSPVVRVMTFVGHSTGKSTKGFTQKEQLEVVKRFREGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLVQRMGRTGRQRQGRVVVILAEGREERTYNQSQSNRRSIQKAISGNKMLHFYQHSPRMIPEGINPELHRMFITAEKYKPNDSGRLPKGRPSSLHHKSALFSCVTDPKEMHCHENWSLSPEEFEIWDRLYRLKENDGVKEPILPHTRFETLENLDKTSKPEEEAAHKLSLSEWSIWQSRPFPTSMVDHSDRCYHFISVMELIEVMRQEQGDCSYELELQPHLRIEDIHVRRNKGHLSTTSSAFAQKTHSSKRDMARTKRPFVPDVNDNEREFFSIFKTTNTKTPRTAPGLDLEEPELPTDTNGSEPCSARRLTLVASTDQGSPKEEEIEKVTFDLNEFNDLCDDGESTVAHESAAVKDLRLLDKHCSSVGLNHTDLGYSSFTAEKSPASSDLFYLPESHVDSFVLVSSSAELAGLEGAFSCVKGLLAHSPPPVSKLEGIEELLRHEETLCPLPKVSCRSYSGQLPHGDFPSSLAVDQSLLPAESPELEVTIGLSAAVNTCVSKPASTPTAAGGAEERPPGGGSFHSLLGKEGFTANHTDNPPNKHFVQGDEEDSEMKRDVTIDGEKSIHLFEDEHTYKVNDEMPSVDVEPLLRLGSGGHTARPSAGPASQQPPSGDSPRGDTACGEGAARGEMAPGGAWGRGSAAEQALHNSELCDYSQELFSVNFDLGFSIEECEEEIFEGDTDAMNTPKLNSASRSRADVQLTANRKSLNDGCRVQTPPKWDCKGLKGRNISTPLPLQSGHVRDTAVPGGTAGGRTGRGSPGASPPSPATPTGRRVSSAEATRRIRKKVFSTVREETPEVCPTDKVNPNSQRNSFGSSASDALHTTGGRTENLEGTNLHTSRVFPAEGTSSESEEEIVFQRKNRRNNVLRSPDVGSDSDFGSPVCAVRKRRHPLTVSDVSSDDGVDFHKNPNRGTRGCSAAGSKAQLRGVKRQKVRSKVTCKNAARQFLDEEAELSQQDESCVSSDETEDTDKELSSSLAQFLNDDAEVTQVLNDSEMRGVYLKSVRSPALGSRYRMVHREFNSTEIFSQIPEQDEAYAEDSFCVAEGDEETCNKSESSEEEEVCVNFDLLNNESFGGGGGRYLTRRRKKLHGANMEQNCSAPVQKKPSRIIVLSDSSGEETNVSNEKGTAAHCSRAGRENAELLTSMPSVSSVPHKKSAGDVSAHQSAESKSGMLLGLKASVSEVLDFHPGPRSGSGKEALQAAAQHLQLESSVKNSAGNAPGATKASPALLDGDTALCVLVDSREISSGADVISSLKAVHGLKVQVCSLGSGDYVVSNRMAVERKFQSELLSSVNRTKVTQRLQRLQGMFERVCVIVEKDRTRPGETSRFSQRTQHYDATLAALLQAGIRVLFSSCQEETAVLLKELALLEQRKNAAICVPTEVEGHKQEMLNFYLSLPNISYLAALNMCHHFSSVRTMVNSSPSDIAAGARVSLQRAEETYRYLRYGFDTQMLPESLCAKGKSNTATRS
What is the function of this protein?
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity).  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393).  In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity).  Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity).  This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity).  In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity).  In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (By similarity).
What are the official names of this protein?
Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.