PharMolix/UniProtQA huggingface dataset:
Protein: GARP_ECO57
Sequence: MILDTVDEKKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFVVGDIKRMELQK
What is the function of this protein?
Probably involved in the uptake of galactarate and/or D-glucarate (By similarity).  May also transport D-glycerate (By similarity).
What are the official names of this protein?
Probable galactarate/D-glucarate transporter GarP, D-galactarate permease.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Phthalate permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EBPS_STAAU
Sequence: MSNNFKDDFEKNRQSIDTNSHQDHTEDVEKDQSELEHQDTIENTEQQFPPRNAQRRKRRRDLATNHNKQVHNESQTSEDNVQNEAGTIDDRQVESSHSTESQEPSHQDSTPQHEEGYYNKNAFAMDKSHPEPIEDNDKHETIKEAENNTEHSTVSDKSEAEQSQQPKPYFATGANQANTSKDKHDDVTVKQDKDESKDHHSGKKGAAIGAGTAGVAGAAGAMGVSKAKKHSNDAQNKSNSGKVNNSTEDKASEDKSKEHHNGKKGAAIGAGTAGLAGGAASNSASAASKPHASNNASQNNDEHDHHDRDKERKKGGMAKVLLPLIAAVLIIGALAIFGGMALNNHNNGTKENKIANTNKNNADESKDKDTSKDASKDKSKSTDSDKSKDDQDKATKDESDNDQNNANQANNQAQNNQNQQQANQNQQQQQQRQGGGQRHTVNGQENLYRIAIQYYGSGSPENVEKIRRANGLSGNNIRNGQQIVIP
What is the function of this protein?
Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM).
What are the official names of this protein?
Elastin-binding protein EbpS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENH1_HUMAN
Sequence: MIFAGKAPSNTSTLMKFYSLLLYSLLFSFPFLCHPLPLPSYLHHTINLTHSLLAASNPSLVNNCWLCISLSSSAYTAVPAVQTDWATSPISLHLRTSFNSPHLYPPEELIYFLDRSSKTSPDISHQQAAALLRTYLKNLSPYINSTPPIFGPLTTQTTIPVAAPLCISWQRPTGIPLGNLSPSRCSFTLHLRSPTTNINETIGAFQLHITDKPSINTDKLKNISSNYCLGRHLPCISLHPWLSSPCSSDSPPRPSSCLLIPSPENNSERLLVDTRRFLIHHENRTFPSTQLPHQSPLQPLTAAALAGSLGVWVQDTPFSTPSHLFTLHLQFCLAQGLFFLCGSSTYMCLPANWTGTCTLVFLTPKIQFANGTEELPVPLMTPTQQKRVIPLIPLMVGLGLSASTVALGTGIAGISTSVMTFRSLSNDFSASITDISQTLSVLQAQVDSLAAVVLQNRRGLDLLTAEKGGLCIFLNEECCFYLNQSGLVYDNIKKLKDRAQKLANQASNYAEPPWALSNWMSWVLPIVSPLIPIFLLLLFGPCIFRLVSQFIQNRIQAITNHSIRQMFLLTSPQYHPLPQDLPSA
What is the function of this protein?
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
What are the official names of this protein?
HERV-H_2q24.3 provirus ancestral Env polyprotein, Env protein HERV-H/p62, Env protein HERV-H19, Env protein HERV-Hcl.3, Envelope polyprotein, HERV-H/env62.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I H env subfamily.
What are the subcellular locations of this protein?
Virion. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass membrane protein.
Protein: IF3_SOLUE
Sequence: MYPGRNFPPRRQNRRENVNESIRVREVRAVFPDGTTEVMPTAAALRKAQELGLDLVLIAPTAVPPVAKAVDFGHYQYDLKKKQHDARKKQHVVQVKELKFRPNTDDHDYDFKKKHAIRFLQEGNRVKAVVQFRGREIAHADLGKKLLMRFAADLTAYGTVEGMPRLEGRNAHVLISPVKTLIKSEKPEKPEKPEKSEKTEKQGPSTPPAPSAS
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_MYXXD
Sequence: MTLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGKTTMSVALAMGLRKRGRRAVAALREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLHAITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMNDRFLRNVIVGLGGKAQGVPREDHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDALMPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFLDIKCRGSGLWPRGVVLVVTLRALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFGLPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSRGGDGSLELADCVLEMLDGTDAAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAKTHLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHDDGRVTGLMQGE
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: LUXS_LIMRT
Sequence: MAKVESFTLDHTKVKAPYVRLITVEEGAKGDKISNYDLRLVQPNENAIPTAGLHTIEHLLAGLLRDRLDGVIDCSPFGCRTGFHLITWGEHSTTEVAKALKSSLEEIAYKTKWEDVQGTTIESCGNYRDHSLFSAKEWSKKILDEGISDKPFERHVVD
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: SCM3_SCHPO
Sequence: MCNRQPKAVDLPPNYSCPHLLSFQSVEFNTNPTACDDVFCKRIESEKKYNDFLESLFKKYGRDTSDIADEVDLATGEIIVNNGHLEALKTKDDIWDPTFNNLEISASNGYEKKLDSSIGNPGEKAVSPVHIEDFQSPQIYKFKNLSLRDEMVSDCVFADEVPLASLFVENVCNETIPSQSCVRLKINDKTRKVDASALEKKSCLLPNSSGTLTDQRGLDTIKHKSIEQNEILHVISDTLSSPRRRNPLLSSPKTPLRRSFSKSKVRNSNSTKRRNFISLISMISPRPNLSTHHFNLGFQPLSQQTSFSGSSTQNPHSSSTCKKAFCFQCISESKKC
What is the function of this protein?
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.
What are the official names of this protein?
CENP-A histone chaperone scm3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FLIW_CLOK1
Sequence: MKLNTKYHGLLEYDEKNIVVFRKGIPGFEHLKKFILVPAEENNLFYILHSIEDENIGIIVASPFDILKDYEFELNEDKTAELKIENMEDIFIVNTVTLNSVLENITINLKAPIVINIKENIGEQLILDKVEYPIKYPLFKGEVSC
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_FERNB
Sequence: MKEYKPQEIESKWQGVWSEKKVFETPQYSDKKKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMQGYNVLHPFGYDAFGLPAENAAIAHKIHPKKWTLDNINVIRGQIKKIGISYDWNREVITCTEDYYKWTQWVFLKLYEAGLAYKKPGAVNWCPSCQTVLANEQVKDGKCERCGTTVTMKYLEQWYFKITDYAEKLLEGLDRLPGWPEHVKTMQRNWIGKSTGAEVDFPVDGMDRKIRIFTTRPDTIYGVTFMAIAPESPLVMELVTEDKKKEVEEFLAKVALEDRFKRTSVEAKKEGVFLGRYAINPLTNEKIPIYVANYILYEYGTGAIMAVPAHDQRDYDFAKTYNLPIKQVIKPKDGEWNINERPYEEEGIMINSGPFDGLESSKGIEEVTKYIEEKGFGKKSVQYKLRDWLISRQRYWGAPIPIVYCEKCGIVPVPEKDLPVRLPENVEFLPTGQSPLTLSEEFKHTTCPKCGGPAHREVETMDTFVDSSWYFLRYVNPKLDDKPFESDDVNYWLPVDQYIGGVEHAVLHLLYSRFITKVLHDLGYLKFDEPFENLFTQGMIYKDGWKMSKSKGNVVSPDDMINKYGADTLRMYILFMAPPEKDAEWNDAGIDGVNRFIKRLWNNYYKILDIINSNDTKNENEFGKEEKNLRRKLHAMIKKIKEDIEGGFKFNTAIAGLMEFNNQLSDYLENTKSPNKKLLREIAEKVVLILSPFAPHMAEEMWHDLGKETLIVEEKWPEYDPEALKEDELTIVVQVNGKVRGKITVPADASEEEIKNRAVENAGKFLEGKTIVNTIYVKGKLVNIVIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIDA_CERVI
Sequence: MIQVLLVIICLAVFPYQGSSIILESGNVNDFELVYPKKVTVLPTGAMNSAHPCCDPVTCKPKRGEHCISGPCCRNCKFLSPGTICKKAKGDDMNDYCTGISSDCPRNPWKD
What is the function of this protein?
Inhibits ADP-induced human platelet aggregation.  Antagonist of alpha-IIb/beta-3 (ITGA2B/ITGB3) (By similarity).
What are the official names of this protein?
Disintegrin CV-11-alpha, CV11.
What is the protein family that this protein belongs to?
Belongs to the disintegrin family. Dimeric disintegrin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_NOCFA
Sequence: MTAAVTQDNTSRTGAAAGRVVRVIGPVVDVEFPRGAIPELFNALHADITLTSVAKTLTLEVAQHLGDNIVRTISMQPTDGLVRGATVTDTGKPISVPVGDVVKGHVFNALGDCLDTPGLGRDGEQWGIHRKPPSFDQLEGKTELLETGIKVIDLLTPYVKGGKIGLFGGAGVGKTVLIQEMITRIAREFSGTSVFAGVGERTREGTDLHLEMEEMGVLQDTALVFGQMDEPPGTRMRVALSALTMAEYFRDVQHQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSLQAIYVPADDYTDPAPATTFAHLDATTELSRPISQKGIYPAVDPLTSTSRILEASIVGDRHFAVANEVKRILQKYKELQDIIAILGMDELSEEDKVLVGRARRLEKFLGQNFIVAEKFTGQPGSVVPLEQTIDDFDRVCKGEFDHYPEQAFNSCGGLDDVEKAAKKIAGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NDHI_SPIUR
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GLMM_THET8
Sequence: MRRYFGTDGVRGEAGKPPLTPEFVLKLGQAAGAYFLAQEKRPVVLLAKDTRESSDLLEAALAAGLMSQGVRVEHLGVLPTPGVAHLTKALKATAGAVISASHNPYQDNGIKFFGPTGEKLPDGAEEEIERLLLEDHPTRGIGTVGDFREAERMYLDFLLAHAPDLTGLKVGLDLAHGATYRIGPKLFQKAGAEVMAFFNTPDGRNINRGCGSTHPEALSRFVVELGLDLGIAFDGDGDRVQFIDRKGRLFHGDHVLYLAALAFGEKGVVGTVMSNMALEVALKERGLAFHRAAVGDRYVLEKLKETGLALGGEPSGHVIFLRHHTTGDGLLTALLTLKALKALGGDLADWYEALPLYPQVLLNVRVSDKAKVMADPRLGEAVREAEARLGGRGRVNVRPSGTEPVVRVMVEAEEGAEEVARELAERVRALSQEAQAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: REV_HV1SC
Sequence: MAGRSGDSEEELLKTVRLIKFLYQSNPPPKPEGTRQARRNRRRRWRERQRQIRSISGWILSNYLGRLAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: SYFA_ACTP7
Sequence: MQHLKELTEKARSALDALDQGLDALEEFRVEYFGKKGHFTALMQELRNVAAEERPAIGAKINEAKQTILDILNAKKEAWEQEALNAKLAAESIDVSLPGRKTELGGLHPVSITIERVVKFFSELGFTVASGPEIETDYYNFDALNIPAHHPARADHDTFWFDAQRLLRTQTSGVQIRTMENMQPPIRIVAPGRVYRNDYDQTHTPMFHQIELLYVDKKANFTELKGLIHDFLKAFFEEDLQVRFRPSFFPFTEPSAEVDVMRQNGKWLEVLGCGMVHPNVLRNVGIDPEEYSGFAVGMGVERLTMLRYNVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_DECAR
Sequence: MQDKYTPADIERAAQQHWDKTGAARAVEDATKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRFHKMQGYNVLQPMGWDAFGMPAENAALQNNVPPAGWTYSNIDYMRQQLKSLGFAIDWEREFATCTPEYYRWEQWLFTRLYEKGLVYKKLGTVNWDPVDHTVLANEQVIDGRGWRSGALIEKREIPMYYMKITAYAEELLSELDNLPGWPEQVRLMQKNWIGKSTGVRFAFPLADNPDEKLWVFTTRADTIMGVTFVAVAAEHPLATKAAANNPELAAFIEECKKGGVAEADIATMEKKGMPTGIYVTHPLTGQQVEVWVGNYVLMSYGDGAVMAVPAHDERDFAFALKYNLPIKQVVAVDGETAFSHEAWAEWYADKAKGKLVNSGKYDGLGYEAAVDAIAADLAAKNLGDKKVQFRLRDWGISRQRYWGCPIPIIHCKTCGDVPVPDDQLPVVLPENVEITGAGSPLAKMPEFYECQCPKCGGDARRETDTMDTFFESSWYFLRYACPDNTTAMVDERVAYWCKGGIDQYIGGIEHAILHLLYSRFFTKLMRDVGLIGDLGEPFANLLTQGMVVAPTFYRELDGGKKQWINPADVDVVTDERGRPTGATLKTDGLPVVIGGTEKMSKSKNNGVDPQALIDQYGADTARLFIMFASPPDQSLEWSDAGVEGAYRFLRRLWKTTYDHLQAGLVAASTSNDGLSSAQADLRRKLHQTMGKVADDYGRRKQFNTAIAAVMELLNAYDKCDLKDAAGRALAQESLESIALLLFPIVPHIGQALYAQLRPGADAGNAAFPKADPAALKQDEIELMVQVNGKLRGAIRVSAEADKATIEATALANEDAIKFMEGKPAKKVIVVPGRLVNIVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIKR_BRUA1
Sequence: MQRITITIDDDLMAALDRMIEIKGYQNRSEALRDLARTGLQQASLEEGQMEACVGVLSYTYDHSARDLSKKLTNTHHDHHNISVASMHVHLDHDRCLEVSILKGKTDDVRHFADHVKAERHVTHGTLAVLPL
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: TY3H_SCHMA
Sequence: MKMTMMCDESIEENNKSSTVELNHNEKDGRIHSIIINFHPITHEQSNNQFYIQTLHEILKYIIDKKLNLVHFETRPTLTLSNANRDVQYSCLITLEANEINMSLLYEELRGNSFISGINLLNNQESEDWYPKHISDLDKCQHLLRKFQPELQTDHPGFHDKVYRERREAIAKIAFQYKYGDRIPEVEYTKEEIETWGLVFTKMKAVHASRACREYIDGFQLLEKYCNYNSESIPQLQTICEFMHRTSGFRIRPVAGLVSPKDFLASLAFRVFQCTQYIRHHSRPMHTPEPDCIHELIGHMPMLVNRQFADFSQELGLASLGASEEEITRLSTLYWFTVEFGLCNENGETRALGAGIMSSYGELENAFSDLSVKEPFNINDAAVQVYDDVGYQKIYFVTESIESMKRELRNYINTSGKSTIPIYDPITETVHMKSRFSIRKELLKHVKEEIGQLDTLLNHSNYTLP
What are the official names of this protein?
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: NIKR_ECOLC
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: NFUA_SHEHH
Sequence: MITISETAQAHFVKLLSDQPEGTHIRVFVISPGTAQAECGVSYCPPDAVEADDTEFEFNGFNAMVDEKSAPFLEEATIDFVTDQLGSQLTLKAPNAKMRKVSDDASLSERIEYVIQSEINPQLASHGGNIMLVEITEEGIAVLQFGGGCNGCSMVDVTLKDGIEKQLLEMFPSELTGVKDVTEHQHGEHSYQ
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: AQP2_HORSE
Sequence: SIAFSRAVLAEFLATLLFVFFGLGSALNWPQAMPSVLQIAMAFGLAIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAALLHEITPPDIRR
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Protein: ASM3_CAEEL
Sequence: MLLGLLVLSLAFQGTLAVTECEECKSIVDLLQFEWGEKKTEECVMEIAVFICETFHIEDNDVCNFIISDFSDEFMYVIKQILVTPHQLCGLLMKNDCGDFVDPLATIWNMTIPGNQPPFVPKQVVPPGNPTLRALHLTDLHVDMFYTVGLEADCGTPQCCRPQDMNVEIVENGDVKQPAGPWGSVGSCDTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSHTVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEYNGCYMKKIYDGLRMISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYYKIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDYFPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNVKWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKYSARFATSNERRRGKEECKI
What is the function of this protein?
Converts sphingomyelin to ceramide.
What are the official names of this protein?
Putative sphingomyelin phosphodiesterase asm-3.
What is the protein family that this protein belongs to?
Belongs to the acid sphingomyelinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3273_BURM7
Sequence: MDIALDLQSIAVQEKTLVFPQFDAARAWALGSQLREFALARGHAVAIDVRTFGQPLFFALVDGATPDNVDWARRKGNVVAHFRRSSYAIGLRLQQAGATLADKHGLPAAEYASHGGAFPIAVAGAGVIGSVTVSGLPQRGDHELVVEALCAQLGHAYATLALTGN
What are the official names of this protein?
UPF0303 protein BMA10247_0773.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: ACDA2_METKA
Sequence: MGIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREVARTIVTLCCEGTAGLISTARLVVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDLEAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLLAMEIADATPSTLMEVTESEEVFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVGPLSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEEAVEVLVTEEDAVYVEEPIKAVEIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRNVGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERGYLVLVPGCLAVALGSYLDDDGKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVIAWGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHLRCVVSDWKEAAITAARLCMRPNDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDIPVTLRSEIRELLEETGWTPRSRASDPTLLPEG
What is the function of this protein?
Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
What are the official names of this protein?
Putative acetyl-CoA decarbonylase/synthase complex subunit alpha-like, ACDS complex subunit alpha-like, ACDS complex carbon monoxide dehydrogenase subunit alpha-like, ACDS CODH subunit alpha-like.
What is the protein family that this protein belongs to?
Belongs to the Ni-containing carbon monoxide dehydrogenase family.
Protein: FDHE_STUS1
Sequence: MAGTILEPGQIEAAASKPPFTNLPPRDLFALRSARLAKLAEDHPLADYLRLLAGVCQAQQQVLDNPPASAPLDPARTRECFKHAMPPLAADTLVREGAWLPLLDAWLDAFAVPDNLSVIAAVDQLRRADSGQRKAWAVALVSGQYDSLPPALVPFLGAALQLAWTHWLLQLDLSDLREREDQTLCPCCGAPPMAGVIRHRGQLNGLRYLVCSLCACEWHYVRLKCSHCRSTKKLDYLHFEGSPQGIKAEACPECNGYLKQLYLELAPDGESLSADLATLDLDLLLADQGYNRQAPNLLLAPGHEA
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
Protein: FER_MYCBO
Sequence: MTYVIGSECVDVMDKSCVQECPVDCIYEGARMLYINPDECVDCGACKPACRVEAIYWEGDLPDDQHQHLGDNAAFFHQVLPGRVAPLGSPGGAAAVGPIGVDTPLVAAIPVECP
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
Protein: ENO_BRUA4
Sequence: MTAIIDIVGREILDSRGNPTVEVDVVLEDGSFGRAAVPSGASTGAHEAVELRDGGSRYLGKGVEKAVEAVNGKIFDAIAGMDAESQLLIDQTMIELDGSANKGNIGANAILGVSLAVAKAAAQATGLPLYRYVGGANAHVLPVPMMNIINGGAHADNPIDFQEFMILPVGASSVREAVRYGSEVFHTLKKRLKDAGHNTNVGDEGGFAPNLKNAQAALDFIMESIEKAGFKPGEDIALGLDCAATEFFKDGNYVYEGERKTRDPKAQAKYLAKLASDYPIVTIEDGMAEDDWEGWKYLTDLIGDKCQLVGDDLFVTNSARLRDGIRMGVANSILVKVNQIGSLSETLDAVETAHKAGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARSDRTAKYNQLIRIEEELGKQARYAGRNALKFL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.