PharMolix/UniProtQA huggingface dataset:
Protein: PUR9_SYNPW
Sequence: MAPTALLSVSDKSGLLPLAKTLHERYGYQLLSSGGTAKVLQEAGLPVTPVADHTGAPEILGGRVKTLHPRIHGGILARRGDPAHEADLQAQQITPIDVVVVNLYPFRETVSDPAVSWERAIENIDIGGPTMVRSAAKNHDHVAVLTDPDQYDRFLQDLAASGGAVSAAVRRRLALDAFAHTAAYDAAITRWMQNRPELQPADDGSASSLPWLEALPLRQRLRYGENPHQGAAWYSAPKAGWGGAIQLQGKELSTNNLLDLEAALATVREFGYGEGGSHPAQRPAAVVVKHTNPCGVAVADGHAAALTRALDGDRVSAFGGIVAVNGRVDAPAARELTSLFLECVVAPEYAPEAREILASKGNLRLLELPPTAIDAAGHDHVRSILGGLLVQDLDDQPVAADGWTVASERAPSQAERDDLCFAWQLVRHVRSNAIVVARNGQSLGIGAGQMNRVGSARIALEASGDGARGAVLASDGFFPFDDTVRLAAQHGITAVIHPGGSKRDQDSIKACNELGLAMLLTGQRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: PSBJ_ORYSA
Sequence: MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MNHF1_STAA1
Sequence: MNHNVIIVIALIIVVISMLAMLIRVVLGPSLADRVVALDAIGLQLMAVIALFSILLNIKYMIVVIMMIGILAFLGTAVFSKFMDKGKVIEHDQNHTD
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit F1, Mnh complex subunit F1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRHO_BRUSU
Sequence: MDPMSNLPFTVAALYCFAPLPQYESLREPLAQLCCANGIKGTLLLAAEGINGTVAGSAGAIEKLIAHITAIPGLGEPELKYSHASEMPFHRMKVRLKREIVTMGVEGIDPLKSVGTYIAPKDWNALIADENTVVVDTRNDYEYAIGTFEGAIDPQTRTFREFPEWVKQNRDRLEGKKIAMFCTGGIRCEKATAFVKGLGFDDVYHLKGGILKYLEEVPREQSVWNGECFVFDERVAVGHGLAESDVELCRACRRPLTPQDKLSQFFEEGVSCAGCYAERTPEDRARYAERQKQVKLAEKRGANKHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: ARGB_SINFN
Sequence: MSASESEIQARLLAQALPYMQRYENKTIVVKYGGHAMGNPELGRAFASDIALLKQSGVNPIVVHGGGPQIGAMLNKMGIESKFEGGLRVTDEKTVEIVEMVLAGSINKEIVALINQTGEWAIGLCGKDGNMVFAEKARKTIKDPDSNIERILDLGFVGEVVEVDRTLLDLLARSEMIPVIAPVAPGRDGHTYNINADTFAGAIAGALNATRLLFLTDVPGVLDKQGNLIKELSVAQAHALIADGTISGGMIPKVETCMEAIKAGVQGVVILNGKTAHSVLLEIFTERGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMS1_ARTAN
Sequence: MSLTEEKPIRPIANFPPSIWGDQFLIYEKQVEQGVEQIVNDLKKEVRQLLKEALDIPMKHANLLKLIDEIQRLGIPYHFEREIDHALQCIYETYGDNWNGDRSSLWFRLMRKQGYYVTCDVFNNYKDKNGAFKQSLANDVEGLLELYEATSMRVPGEIILEDALGFTRSRLSIMTKDAFSTNPALFTEIQRALKQPLWKRLPRIEAAQYIPFYQQQDSHNKTLLKLAKLEFNLLQSLHKEELSHVCKWWKAFDIKKNAPCLRDRIVECYFWGLGSGYEPQYSRARVFFTKAVAVITLIDDTYDAYGTYEELKIFTEAVERWSITCLDTLPEYMKPIYKLFMDTYTEMEEFLAKEGRTDLFNCGKEFVKEFVRNLMVEAKWANEGHIPTTEEHDPVVIITGGANLLTTTCYLGMSDIFTKESVEWAVSAPPLFRYSGILGRRLNDLMTHKAEQERKHSSSSLESYMKEYNVNEEYAQTLIYKEVEDVWKDINREYLTTKNIPRPLLMAVIYLCQFLEVQYAGKDNFTRMGDEYKHLIKSLLVYPMSI
What is the function of this protein?
Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:11032404, PubMed:11185551, PubMed:11289612, PubMed:10626375, PubMed:27488942).  Catalyzes the formation of both olefinic and oxygenated sesquiterpenes, with amorpha-4,11-diene being the major product (PubMed:11032404, PubMed:11185551, PubMed:11289612, PubMed:10626375).
What are the official names of this protein?
Amorpha-4,11-diene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_BACCQ
Sequence: MWNEFKKFAFKGNVVDLAVGVVIGAAFGKIVSSLVKDVITPLLGMVLGGVDFTDLKLTFGKSSIMYGNFIQTIFDFLIIAAAIFMFVKVFNKLTSRKEEEEKEEEIPEPTKEEVLLGEIRDLLKQQNSSKDRA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y84_SIRV1
Sequence: MNYLRRKMKMSETTLVLTIISTTTTTLFAIIQLYLKIKQALKDAVKEIVNSELSNLKTEIEELKIKQDELSRQVEEIKRKLDQK
What are the official names of this protein?
Uncharacterized protein 84.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: XPOT_ORYSJ
Sequence: MDDLEQAILLASDSPAAAAASPAVRAEALAYCARARDETPPSSLLHLCLYGLASSPHAHVHFWCLQTIHDALLLRRRLALPDDLALLRSSLLSLAVSSNAASPPFLRNKLAQLLALLVRFEYPHVYPSYFLDLIPPSPPLPGPTDMFARVLVSLDDDLLSQDYPRNAEEASDAGRVKDAMRAQCVPQIARHWHEAAVSLRAADPAVAAVALDAARRCISWIDVSLVANDVFVPLLFDIALSPGSVAPLAAAAVGCLSAVAAKRMDARAKVALLRSLMSAQKGFGSPDSGLKMAHLVTAYAVEALECYRKLGSSDADGAAALEMLEEVLPAVFAAAESGDDDEVDSGSVLEFLSGYVSTMKAPTEKQLGHLGQILEVVRMQMSYDPVYRGHLDVLDKIGKEEEDLMAEQRKDLIALFRSICRVAPGATQLFIRGLLVTALSSAEVSVEDVEVALTLFYRLGEIVGEEEIRTGAGLIRELVPMLLSARFSCHTHRLVALVYLDTISRYIKFMQENDQYVPHLLTVFLDERGIHHQNAHVSCHAGYLLMRAIRLLKAKLVPYLDTILQSLQDALVQFTATDWANKDIKFSSSEDGSQIFEAVGLLIGIEEVSPDKQVQCLTALLNPLCQQIESLVMDAKAQGLEESSPRAIGLQQIIVALTMISKGFNERLVMGSRPTLGVMFKKTLDVVLQVLISFPNVKPLRSKIISFLHRMVEILGISVLPCIPIALRQLLVDNEAKDMSEFLYLINQIICKFKSSANALLEDVFPAIASHLSVILSHDAFSNGFASNTEEMRELQELEKRFYAFLLHIATHDLSTVLLTPSCRHYLENIMQLLLITSCSHKEISHRKTCVQTFVNLIKDWCSSSEIEDKLPGFRVFMIEKFATGCCLQSVLDKSFNFRDGISIALFGEIMMAQKVMYERFGENFVVNFVTKLREAHCPPDLAEQYYQKLQGNDIKAFKSFYESLVMKIRQQQNGSLVFR
What is the function of this protein?
Probable tRNA nucleus export receptor which regulates tRNA processing and facilitates tRNA translocation across the nuclear pore complex.  Is required for correct leaf initiation at different developmental stages and may play a role in floral patterning.
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Protein PAUSED homolog, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: DNLJ_AERS4
Sequence: MSETLSRHRQLCDLLTEYGHQYYVLDNPTVPDAEYDRLMRELIAIESEHPELKTSASPSVRVGGQPLTAFRQVRHEIPMLSLDNVFSSEELQAFEQRMKDRLKREISFTFCCEPKLDGLAVSLLYVDGQLVQAATRGDGATGEEITENVRTIKAIPLSLRGSDWPARLEVRGEVFMPKAGFEAMNAKALAAGEKVFVNPRNAAAGSLRQLDSRITASRPLNFYAYGVGVGGDQLGDSHFGRLCQLKAWGLPMSPEVKLKEGAAGCQAFHDDILARRGELAYEIDGVVYKVDAIPLQEELGFVARAPRWATAHKFPAQEEMTLLENVEFQVGRTGAVTPVAKLKPVFVGGVTISNATLHNADEIERLGVMIGDTVIVRRAGDVIPQIVAVVEAQRPVDAREILFPTQCPVCGSALERLEGEVVTRCSGGLFCEAQRKEAIKHFAARRAMDVDGLGDKIVEQLVDKGLVKTPADLFSLNAIQLAGLERMGQKSALNLVAAIDAARSTTLPRFLFALGIREVGEATALNLANHFLTLDALRAASVEQLLEVADVGDIVAKHVYYFLRQPHNIEVLAAGIHWPAIEKKEASEQPFAGKTFVLTGTLNLLSRNDAKAALQALGAKVAGSVSAKTDVLVAGEAAGSKLAKAQELGITIWTEEQLQAALQS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: GRPE_ACIC5
Sequence: MSRKLHEEELTPEGMDAAQNADPAGDPVSENEGALPAAEPQAQILQEEVERLRAERDAALADREAFQDRLARLQAEFDNARKREAKERSEFRDYSVASTAEAFLPVLDNFQLALASTGTAEQLRMGVELIVKQMDEALRSLSIIPIETVGAQFDPRVHEALEMVEREDVPDHQVIEEVRRGYRIRERLMRPALVRIASNSKQTQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR7_CALVO
Sequence: AXGQDFMRF
What are the official names of this protein?
CalliFMRFamide-7.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSC_ECOBW
Sequence: MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: RL28_ACIBT
Sequence: MSKVCQVTGKRPVVGNNVSHANNKTKRRFEPNLHHHRFWLESEKRFVRLRLTTKGMRIIDKLGIEKVVADLRAQGQKI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: YADH_CLOBE
Sequence: MYKIVSKKELTNNIFSMDIEAPRVAKSAKPGQFIIIKNDEKGERIPLTIADYDQEKGTVTIVFQTVGKGTKQLAAFNEGDHVADFVGPLGVPSEFIHEDIEELKKKNFIFVAGGVGAAPVYPQVKWMHEHGIAVDVILGSRNKDLLIYEEKLNKAAGNLYVTTDDGSYEFKGTGSDMLKELVNNQGKKYDHAIIIGPMIMMKFTSMLTKELGIPTTVSLNPIMVDGTGMCGACRVTVGGEVKFACVDGPEFDGHLVNYDESMRRQAMYKTEEGKAQLEVEEGNTHSHGGCGCRGDK
What are the official names of this protein?
Uncharacterized protein in adh 3'region.
Protein: HIS4_GEODF
Sequence: MIVIPAIDLKEGKCVRLEQGLMERDTVYSDDPAAQALVWEAKGAELLHIVDLDGAFAGEPKNRGAIEAIVKALKITTQLGGGIRDLATIEAYLGMGIGRVIIGTAAQRNPELVQEACRKFPGRIVVGIDAKNGMVAVQGWAEVTGVTAIDLAKKFEGFGVAAIVYTDISRDGMMKGPNIEATRNLAEAITIPVIASGGVSALRDIENLMAVEAAGISGAITGKAIYSGAIELSEAIALTRRGASC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_NEIM0
Sequence: MELKVIDAKGQVSGSLSVSDALFAREYNEALVHQLVNAYLANARSGNRAQKTRAEVKHSTKKPWRQKGTGRARSGMTSSPLWRKGGRAFPNKPDENFTQKVNRKMYRAGMATILSQLTRDERLFAIEALTAETPKTKVFAEQVKNLGLEQVLFVTKQLDENVYLASRNLPNVLVLEAQQVDPYSLLRYKKVIITKDAVAQLEEQWV
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL33_FRAAA
Sequence: MAATDVRPKITMACQVCKHRNYITRKNRRNDPDRLELKKFCPNCGKHTEHRETR
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: Y337_MYCPN
Sequence: MVKKELEMYNLYTFQIDLDKKLLFEKADNQQNYSKIRARYFKNSARNQQAVFLNKNLIKNTFNKALLNFSDFLSGSGVESIFKQVIDDQPEVLNYLKQVKKEDSCDGHSEASQLVFNVVINPKNTLANFFEELTIYLHFNEENNTVVGSFSLKWNIKRADLFSETKNIAINNLIHTFCKNNLNEVSFIQIIKCFAKTLINKQGQIVLESCAFKQKWQNIVEQKYPFSTIHKNLKIVNSDFFDAFFVILLLICHLNNNLLWLCEKTEHFEWKLNSKISNFKEDNTEVYLSKMLLFLKDWYFENQAVTNEDIEKVDEVEDIGKLVEKYSANQPQKLSSNSTVYVFEPDKKQCFLKNDDFFNTNEAKLLFLITMQPNVFGLDDTAIANDLNLREIGDFFKEIDFTDSDVLNDFQQQKETLLVRRTFNQLLFMNSNTDVLSIVNNKFKSAIHNIVWTITYSKAIMLKAFDYSKIFEQNRTNDPSLLRSNLNSINRLRYLSEYFRTASVKYDQLYTKVKEYMQLDQFLVDMINQVNHEDEIFGKYKERVYLSLGIVTAVVFGIIEFFNCVWTVLTVSQQTAEKSLADPRNTVIIGIGTILVLTLLITILTFMTRRLYLFEFNKKHK
What are the official names of this protein?
Uncharacterized protein MG241 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGA_OCEIH
Sequence: MNIQEMILTLQNHWSEHNCILMQAYDTEKGAGTMSPMTLLRSLGPEPWNVAYVEPSRRPDDGRYGENPNRLYQHHQFQVIMKPSPDNIQELYLESLKKLGINPLEHDIRFVEDNWENPTLGAAGLGWEVWLDGMEITQFTYFQQIGGLEANPVTVELTYGIERLASYIQDKENVFDLEWNNGVTIRDIFYQPEYEHSTYTFKESNTDMLFDLFSMYEQEAKQTMEKGLVFPAYDYVLKCSHTFNLLDAKGVISVTERTGYIARIRNLARSISKIYVSEREKLGFPMLQEKGAK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_ALKCK
Sequence: MASLRDIKNRINSTKKTRQITKAMQMVSAAKLNRAQEKAQSYEVYAKKMREVVGNIAQAGSDTSHPMLEERPVKKTGYILMTSDTGLAGGYNSSLLRDMMKTINERHASEDEYAIIVLGRIGRDLLRTRKQPIIQEMVEVPDQPTFNDVSGLAKSSVEMFADGVFDELYIWYNHFVSPMTQRVTEQKLLPLASVNEGDETSSTSLYEFEPSEQQILEAVLPRYAESLIYGALLDAKASEFGARMTAMSAATDNASALIDELTLSYNRARQAAITQEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MTNX_BACC1
Sequence: MSIQVFCDFDGTITNNDNIMSIMEKFAPPEAEEVKNRILSQELSIQEGVSQLFQFIPTNLHDEIIQFLIETAEIRNGFHEFIQFVNKNNISFYVISGGMDFFVYPLLQGLIPKEQIYCNETDFSNEYITVNWPHPCDHHCQNHCGLCKSSLIRKLSNTNDFHIVIGDSITDLQAAKQADKVFARDFLITKCEENHISYTPFESFHDIQNELKHLLEVKL
What is the function of this protein?
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, HK-MTPenyl-1-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MtnX family.
Protein: M920_ARATH
Sequence: MKMKSPLFRGPLVNSSTENPIHILTREKLRHQTSGTNSTEKVILPNILHSYIKNLNLDFTSPYGSTGNNEVLSILRSRFKQSIFPSSGLKCLDTTGDFLIKNVLHKRYESVQKNISNALSSSINSRTAVFFCILFSITVLMEIAPGPLLKKPSLLFSDNLPNVLQYTRDVYVNHVCIIHKSLSPCECEEPLNRIIRDMFPQTTFDPLELQKPSPQ
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg00920, ORF215b.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYC_BACCQ
Sequence: MTIHIYNTLTRQKEEFIPLEENKVKMYVCGPTVYNYIHIGNARPPMVFDTVRRYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTIADRFVEAYFEDVTALGCKHATVHPRVTENMDIIIEFIQELVNKGYAYESEGDVYFRTKEFEGYGKLSHQPIADLRHGARIEVGEKKQDPLDFALWKAAKEGEIFWESPWGQGRPGWHIECSAMARKYLGDTIDIHAGGQDLAFPHHENEIAQSEALTGKTFARYWMHNGYININNEKMSKSLGNFILVHDIIKQYDPQLIRFFMLSVHYRHPINFSEELLRSTNNGLERIKTAYGNLKHRMESSTDLTDHDEKWLADLKKFQTAFEEAMNDDFNTANAITELYNVANHANQYLLEEHTSTVVIQAYVKQLETLFDILGLELAQEELLDEEIEALIQKRIEARKNRDFALSDQIRDDLKDRNIILEDTAQGTRWKRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE1_HPV42
Sequence: MADDTGTEEGLGCSGWFCVEAIVDKTTENAISDDEDENVDDSGLDLVDFVDNSTVIHTKQVHAQALLNKQQAHADQEAVQALKRKLLGSPYESPVSDSQHSIDNELSPRLGGLTLCRGSQGAKRRLFQSLENRDSGYGYSEVEVQQTQVEHGHGAVHGTMGNGGAVGSELGVQENEEGSTTSTPTTRVVELLKCKNLHATLLGKFKELFGVSFGDLVRQFKSDKSSCTDWVIAAFGVNHSIAEGFNTLIKADSLYTHIQWLTCTWGMVLLMLIRFKCGKNRTTVSKGLSKLLNIPTNQLLIEPPRLQSVAAAIYWFRSGISNASIVTGDTPEWIQRQTILEHCFADAQFNLTEMVQWAYDNDITEDSDIAYEYAQRADRDSNAAAFLKSNCQAKYVKDCGVMCRHYKKAQMRRMSMGAWIKHRSAKIGDSGDWKPIVKFIRYQQIDFLAFMSAFKKFLHNIPKKSCLVLIGPPNTGKSQFGMSLINFLAGTVISFVNSHSHFWLQPLDSAKIAMLDDATPPCWTYLDIYLRNLLDGNPCSIDRKHKALTVVKCPPLLITSNTDIRTNDKWKYLYSRVSLFEFPNPFPLDTNGNPVYELNDKNWKSFFQRLWSSLEFQESEDEEDYGETGQTFRCVPGTVVRTV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MATRX_VSIVC
Sequence: MSSLKKILGLKGKGKKSKKLGIAPPPYEEDTSMEYAPSAPIDKSYFGVDEMDTHDPNQLRYEKFFFTVKMTVRSNRPFRTYSDVAAAVSHWDHMYIGMAGKRPFYKILAFLGSSNLKATPAVLADRGQPEYHAHCEGRAYLPHRMGKTPPMLNVPEHFRRPFNIGLYKGTVELTMTIYDDESLEAAPMIWDHFNSSKFSDFREKALMFGLIVEKKASGAWVLDSVSHFK
What is the function of this protein?
Inhibits mRNA nuclear export through direct interaction with host RAE1-NUP98 complex, thereby preventing interferon signaling and establishment of antiviral state in infected cells.  Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell.  Inhibits host transcription, possibly through interaction with host DNA repair factor IIH/TFIIH GTF2H5 subunit (By similarity).
What are the official names of this protein?
Matrix protein, M protein.
What is the protein family that this protein belongs to?
Belongs to the vesiculoviruses matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host nucleus membrane; Peripheral membrane protein. Host nucleus. Host cytoplasm.
Protein: PRIO_BOBOX
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, Major scrapie-associated fibril protein 1.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: RPPH_FRATF
Sequence: MIDKSGYRANVAIVLLNKQNRVFWGQRRNRTSWQFPQGGVATGETPLQAMYRELHEEIGLRPQDVEVIASTRDWYKYDIPDSLVRTKEPICIGQKQKWFLLKLKSPESYIDLDANDSPEFDNWRWVSYWYPINHVVYFKQEVYRKALTYFKEYIA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: AZOR3_PSEPF
Sequence: MKLLHIDSSILGDNSASRQLSSQVTKAWQAAEPSAVVTYRDLAADAISHFSSTTLVAAGTTAELRNAAQQHEAELSATTLAEFITADAIVVAAPMYNFTVPTQLKAWIDRIAVAGQTFRYTEAGPEGLCGGKKVVIVSTAGGIHAGQASGVAHEDYLKLVFGFLGITDIEVVRAEGLAYGEEVRNNAMSAAQAKISEQLFAAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 3, Azo-dye reductase 3, FMN-dependent NADH-azo compound oxidoreductase 3, FMN-dependent NADH-azoreductase 3.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.