PharMolix/UniProtQA huggingface dataset:
Protein: RLME_METM5
Sequence: MGKKDKRWVLQRKNDHYYNLAKKRNYRSRATYKLFQLNEKFNLIKERNVVVDLGCAPGGWLQAARDIVGDKGFIVGIDLQTVKPLPYENVIAIKGDMTKEEILKQARDLLPEKPDVIICDASPNISGVWDVDHARSLELTTMALMTATKMLKKGGNFVVKVFQGDLFEKYVQLVSEYFDKAFTTKPRASRDESAEVYVIGKRFNGRKFDMNSKSPIVKLLDTNPKENEITSPSLRKDISKEDSGLMIKRIKEMRSKKE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRN3_MEGVI
Sequence: YLDVNQIASYLLCLGEGAVFNGRKTCQIGCRAACQQPGCGGYKECEQIPNIRLHKYRCHCISG
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria and fungi.
What are the official names of this protein?
Megourin-3.
What are the subcellular locations of this protein?
Secreted.
Protein: AMPA_SHISS
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_MYCTO
Sequence: MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXA_HELP2
Sequence: MAKKKIAISCGDIQGVGLELILKSHKEVNAFCEPLYLIDGELLERANQLLHNAYETKTLNALAIHSPLPLLNSSTIGKISAQSGAYSFESFKKACELADSEEVDGICTLPINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCSKLFVGLFSDHVPLSAVSQLIQVEALVKFLLAFQKSTQAKIVQVCGFNPHAGEEGLFGKEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKRKITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRVSTDHGTAFDIAYQNKANNKSYLNAIKYLA
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_ECO81
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RBL_METJA
Sequence: MDYINLNYRPNEGDLLSCMVIKGENLEKLANEIAGESSIGTWTKVQTMKSDIYEKLRPKVYEIKEIGEENGYKVGLIKIAYPLYDFEINNMPGVLAGIAGNIFGMKIAKGLRILDFRFPAEFVKAYKGPRFGIEGVRETLKIKERPLLGTIVKPKVGLKTEEHAKVAYEAWVGGVDLVKDDENLTSQEFNKFEDRIYKTLEMRDKAEEETGERKAYMPNITAPYREMIRRAEIAEDAGSEYVMIDVVVCGFSAVQSFREEDFKFIIHAHRAMHAAMTRSRDFGISMLALAKIYRLLGVDQLHIGTVVGKMEGGEKEVKAIRDEIVYDKVEADNENKFFNQDWFDIKPVFPVSSGGVHPRLVPKIVEILGRDLIIQAGGGVHGHPDGTRAGAKAMRAAIEAIIEGKSLEEKAEEVAELKKALEYWK
What is the function of this protein?
Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA).  Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type III subfamily.
Protein: SYP_DESHD
Sequence: MRVSQILNPTLREVPAEAEVVSHQLLVRAGLIRKSAAGIYTYLPLGLRVLRKIEQIVREEMDAKGGQEVLLPIIQPAELWRESGRWDLYGQELMRLNDRHNREFCLGPTHEEIITDLIRGEIRSYKQLPLLLYQIQNKYRDERRPRFGLMRGREFIMKDLYSFDRDEAGLAESYKKMYDAYTRIFTRCGLTFRPVEADAGAIGGTGGTHEFMVLAESGEAAVVYCPDCDYAANVEKAECKPAPVAGDAPVGAYRGVDTPGTKTIEQVAEFLKVSKSDLVKSLLYQGDDKLFLILVRGDREINEIKVNNALGPFINLQLAGPEVVLEKLGCEPGYVGPIGAPKNLTVVADLEVPLMAKAVCGANAEDKHYVDAVPEKDFRIDQILDLRMVNAGEPCPQCGSPLKEARGIEVGQVFKLGTKYSKALNAVFLDENGAEHPCVMGCYGIGVSRTMAAAIEQNNDKDGIIWPIPIAPYHVIVVPVNMKDDQVRETGEALYQELLKLGVEAVLDDRDERPGVKFKDADLVGYPLRVTVGSKTLANGEVELRDRKTGEVQLVKVEELAGRIQGMIREALGVK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDRP1_DENS1
Sequence: MGHIRSIRLALAVAAVCTAASAAAGDAKFPPLGPLPPVPVPADNPMTADKVALGKQLFWDNRLSGDGSTPCVSCHLPALGWGDGGAISRGYPGTKHWRNSQTIVNSAYYNKLFWAGSVTSLEAQAPSAAEGGVAGNGDRSLMEMRLRFIPEYVAAFKNVFGADWPRMTQAYAAIAAYQRTVVSDATRVPFDRWQAGDKAAMSAEAQRGYALFSGKAGCIACHNGPLASDQRFYNLGLPEHPDLAEDPLLQITHRWEQYQKGTTEDGYRHADRDKGYYYQTKNPKDIGKFRTPSLREVKYTGPYMHNGTLATLDEVVAFYNAGGGTAPGKTDKLKPLGLTEQESKDLVAFVEALSMTEPLIHDDPKLPGDYQPLATQ
What is the function of this protein?
Involved in iodate respiration (PubMed:34215855).  May play a critical role in detoxification of inadvertent H(2)O(2) generated by the iodate reductase IdrA/IdrB (PubMed:34215855).
What are the official names of this protein?
Cytochrome-c peroxidase IdrP1, Iodate reductase subunit IdrP1.
What are the subcellular locations of this protein?
Periplasm.
Protein: RSMH_SHEFN
Sequence: MSQEFAHLSVLLNETVDGLNIQSDGIYIDGTFGRGGHSRHVLSHLGENGRLIAIDRDPQAIEAAKQFADDPRFQIVHGGFGQLAEYVEELGLTGKINGVLLDLGVSSPQLDDAERGFSFLRDGPLDMRMDNSQGQTAAQWIARAEIEDMAWVFKTYGEEKNSRHIARCIAADREKTPFLRTKDLADLIARITKNKERNKHPATRVFQAIRIYINSELEQIDQALEGALAVLAPQGRLSVISFHSLEDRMVKRFIRRHSQGESVPHGLPIMEAELNKSRKLKAVSKALKPSDAELELNPRARSSVLRVAERLDY
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_VIBCM
Sequence: MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDDIILGLIKERIAQADCEKGFLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDKEETVRARLNVYHTQTAPLIEYYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYPBB_PSYBR
Sequence: GFNPCGETCWNKPTCHAPGCTCSIANICVRN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide psybry B.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family.
Protein: DEF2_COREF
Sequence: MTVRPIVIHGDPVLHNPTREVTEPISELQELIADMYETMEVANGVGLAANQIGVSKRIFVFNCPDDEGTMHRGCFINPVLETSEIPETMPADDGSDEEGCLSVPGEGFPTGRADWAKVTGLNEDGEEWSMEGTGFLARCFQHEVGHLDGVVYTDTLIGRWKRLAKKTIKANGWTEPGLTWTPGVDEDPFGHDV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 2, PDF 2, Polypeptide deformylase 2.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RS8_SHIFL
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: LIPA_RHORT
Sequence: MMDTPIIRHPEKVRRPDNPSPRKPEWIRVRAPVSHEAAEVRQLMRSKNLFTVCEEAACPNIGECWKRRHATFMILGDICTRACAFCNVRTGKPGHVDDQEPVNLADSVVAMGLKHVVITSVDRDDLADGGAGHFHRCITEVRSRAPSCSIEVLTPDFRDKPQGALARVVEAGPDVFNHNLETVPRLYPTIRPGARYFHSLKLLDRVKTIDPGVFTKSGIMVGLGETREEVLQVMDDMRSAGVDFLTIGQYLQPTLKHVAVDRFVTPDEFKDYADIARGKGFLMVASSPLTRSSHHADRDFEDLRKARQDAAATK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_MYCTO
Sequence: MIDLKLLRENPDAVRRSQLSRGEDPALVDALLTADAARRAVISTADSLRAEQKAASKSVGGASPEERPPLLRRAKELAEQVKAAEADEVEAEAAFTAAHLAISNVIVDGVPAGGEDDYAVLDVVGEPSYLENPKDHLELGESLGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALKLAVDNGFVPTIPPVLVRPEVMVGTGFLGAHAEEVYRVEGDGLYLVGTSEVPLAGYHSGEILDLSRGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCTPADAEHEHERLLGWQRQMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWIPTQGAYRELTSTSNCTTFQARRLATRYRDASGKPQIAATLNGTLATTRWLVAILENHQRPDGSVRVPDALVPFVGVEVLEPVA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABCC9_RABIT
Sequence: MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGVSDLRFCITGIMVILNGLLMAVEINVIRIRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISEILSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPMQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRVKELSSLKAFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGEASLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPMETEDIAIKVTNGCFSWGSGAATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLDGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQTERICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLSGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDADLVLVFSEGILVECDTGPNLLTHKNGLFSTLVMTNK
What is the function of this protein?
Subunit of ATP-sensitive potassium channels (KATP).  Can form cardiac and smooth muscle-type KATP channels with KCNJ11.  KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
What are the official names of this protein?
ATP-binding cassette sub-family C member 9, Sulfonylurea receptor 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YQGF_LISMO
Sequence: MRIMGLDVGSKTVGVAISDPLGWTAQGVETIQIDENRKQFGYDRVKELVLEYEVEKVVVGLPKNMNNTIGPRAESSKIYAEVLEARIGLPVVLWDERLTTSAAERTLIEADVSRKKRKEVIDKLAAVMILQSYLDTTN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WRNXO_DROPE
Sequence: MDKFLIKMPIKHKNNETPEQKPIVKKETPKAAAKQSNKNTPIQAKEKENAQNDTPKQGRAGRSAKPAAKRKNLDTLEVNTEKNTAESENPPKRRSGRLTRSTRSMAEEGTPSPEKVKPEKLPFIKYRGAIKYFTENQDIAASADDVMQWVDKQTDVDVVPMAFDMEWPFSFQTGPGKSSVIQICVDEKCCYVYQLTNLKKLPAALVALINHPKVRLHGVNIKADFRKLQRDFPEVSADALIEKCVDLGVWCNEICETGGRWSLERLANFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYRDLEQREKQKLINELQFKEQNGEAAFKAVKGLGETFLSKINEITL
What is the function of this protein?
Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction.  Essential for the formation of DNA replication focal centers.  Has an important role in maintaining genome stability.
What are the official names of this protein?
3'-5' exonuclease, Werner Syndrome-like exonuclease.
What is the protein family that this protein belongs to?
Belongs to the WRNexo family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UXT_HUMAN
Sequence: MATPPKRRAVEATGEKVLRYETFISDVLQRDLRKVLDHRDKVYEQLAKYLQLRNVIERLQEAKHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSNSLTKDSMNIKAHIHMLLEGLRELQGLQNFPEKPHH
What is the function of this protein?
Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.
What are the official names of this protein?
Protein UXT, Androgen receptor trapped clone 27 protein, ART-27, Ubiquitously expressed transcript protein.
What is the protein family that this protein belongs to?
Belongs to the UXT family.
Protein: TCPE_HUMAN
Sequence: MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).  The TRiC complex plays a role in the folding of actin and tubulin (Probable).
What are the official names of this protein?
T-complex protein 1 subunit epsilon, TCP-1-epsilon, CCT-epsilon.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: DAPLE_XENLA
Sequence: MDTTISQQMDHFLESPLVTWVKTFGPCGNENESKLAMYMELVDGVFLNKIMVQIDPRPSNQRVNKHVNNDVNRRVQNLTILVRHIKAYYQEVLQQLIVMNLPNVLLISKDPLTDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTHNQENVFDLQWLELSDMAPEELDSLSRNMALHLKRLIDERDECKEVIVDLTQERDYLQFQNHPSPVKSSSPDTSANMVSHLSSEDKKHLAVELAESKAKLRRIRQELEEKSELLLDTKHEVERLNLELQKIKQENFQLASEARTARTYRDEIDSLKERASKVDRLENELARCKEKLHDVDFYKARMDELREDNMILIETKSMLEEQLAAARTRTDKLHELEKENLQLKSKIHDLELDRYSDKNRIEELLEENMVLEIAQKQSMNESAQLGWELDQLSKSTDLSDARKSFVFELNETTSSKILKLEKENQSLQNIIQDLREASLTLEEGNLKGQEWEKENQQLSKKIENLNQQIERERQSSLDLESLSEDLLKEKDQLSQALENIKSQKERQIKELEQENKHLIQTLEAVRQRSQVSTEARVKDIEMENRILHETIKDTSSKMNELEYEKKQLQKAFDQSKEQVEKLDKMEKEVHRLEKQNEILTKKVTSIKIVEEKMQGLEKENEVLEGENIVLKKSLDTLQNVTIKLEVLESENKQLDEENLELRRAVEAMRFSCAKSTQIERENNELQKEKEELQKNVELLKALGKKSERLEVSYQGLNDENWRLQQMLDTGNKKINDLEKELHDTEKENKDLQRTLEEMKICNKRLERMEEENKAKEQEMVQLEKDNKILQKESKRLWQQVELKDAILDDNTVKLADLEKENRALEKEISKLRDLSTKTRDLERENKDLLQQMTVDKRTLATLREDLVLEKLKTQQMSSELDKLSLELEKIGLNKESMLQDENSNAEKKYKLLENKIESTLKTTLAVKENKIVALEMKIEETSSLNQQLQNELNSIKKDIIASKENLRGAAHNSYTQLSSKQDCNSQINGQRETTVELLKFKDRTIELERNNAALQAEKKLFREQLQHLESHNLNLSSQMGTLQKQVTFLQEHNTALQTQTANLQVENATATSQVASLKSQISQFQNQLSARESENEILQQQKEHLRVTHESLLQDHEQLGSLYERQSAEYEGMISQHSSLKSQYKSLEQAHRSLEESYSTLIKHKKELEDLDAVLKKEQDVLQQERRKNFVAMEENQKLKTDLERLNFLHGELQTEYSSLHKHTKEVKTSLNNAQMELNRWQARFDELKEQHQTMDISLTKLDNHCELLTRLKSNLEEENHHLLSQIQMLSQQNQMLLEQSMETKEQYHEEQKQYIDKLHDLRRQKEKLEEKIMDQYKFYDPTPKKKSHWSGAKAIAKLIKPKKEPSRESVKSPTDVQSKTMDNAEMAASPSSMRPLRLQQESLDNSSLGSDEKGSPKVLASKVLVEVAQRQHRMSYHGSSSEQTDGPEHLSRSRRMESGSRAFSTSTIHLTAPAHNAKVPHLSRPKGYNSDDNQSDQLHEAESNAGSSRVPWTSSLEVSRSASNSSSPLTLKGRPESVSSEDMIPTKDIATLSRESNLYHPNAVMLGATKNRESPVNRNSLHLYDYPEKKNSSRTPTRPRPGSPGSEMVTLEEFLQESSRQSPPSRRHSLNDSELITLHQFLFEAETLHPSSQSPSPTLHLKDPSQTAVPKSLPSAENCEWRKRADRASRRAASLYIPRDMVTNRDDMLGDLFKKTEDPPDIRSPMSELIFKDAAQMPTSYVSPTVKVTGNTTKPGQYVKPHPRQLDAPLNVTSSLLHQANVYSATSSSQSPEPQALSPHGAMGSRGNSLSRAFSLASADLLKENGPEVVMQEKSDVETPVGKDFGRYMIRSSTPLGSQSSLREKPQSARMQHMLRGDDRQYRSLDSRRLSLALPKEETTPPQPAPSASSLQQHYTLGHGAIRGKPKLLSRSGEVALVSPVRPISSIPELETTQGLASAGPGKSRSTSPDCSPAPVCEEEPNKSETLKSTPASPDPSADPQTVWYEYGCV
What is the function of this protein?
Positive regulator of Wnt signaling, acting synergistically with dvl2/dsh (PubMed:16026968).  Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (PubMed:16026968).  Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:30948426).  This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (PubMed:30948426).
What are the official names of this protein?
Protein Daple, xDaple, Coiled-coil domain-containing protein 88C, Dvl-associating protein with a high frequency of leucine residues-like, xDal.
What is the protein family that this protein belongs to?
Belongs to the CCDC88 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction. Note=Enriched at apical cell junctions.
Protein: Y1172_DELAS
Sequence: MMLRIPALLSPDEVRQCRQALEQAPWQDGRATAGPLAAQVKANLQLPLDSQAGQAIGNLILDKLGASALFMSATLPLKVLPPRFNRYEGGGTYGNHIDNAIFTIPGTAIKVRSDVSTTVFFSEPDEYEGGELIVEDTFGHQSVKLAAGDAIVYPGTSLHRVNPVTRGTRYASFFWTHSLVASDEKRRILFDLDQQIQQLTVRHPGDPALSALSGTYHNLLRMWSQA
What are the official names of this protein?
PKHD-type hydroxylase Daci_1172.
Protein: PYRC_VIBC1
Sequence: MTTLTITRPDDWHVHLRDGEVLKDTVRDISRYNGRALIMPNTVPPVTNTEMALAYRDRILAEQHGEQFEPLMALYLTDNTTPDEIRKAKATGKIVAAKLYPAGATTNSDSGVTDAKNIYHVFEAMEEVGMLLLVHGEVTHNHVDIFDREKEFLDTVLAPIVNDFPNLKIVLEHITTSDAANFVNNASDNVAATITAHHLLFNRNHMLVGGIKPHFYCLPILKRNTHQQALIEAATSGSKKFFLGTDSAPHAKGAKESACGCAGSYTAHAALELYAEVFENEGKLENLEAFASLNGPDFYGIARNTDTVTLEKASWDVPETMPFGSDIVVPIRANEKIEWEVK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: MSRB3_ARATH
Sequence: MNIVNSKILFLSFTLLLLLQSSIVESDSICLSSGVASTVAMAAPGSVQKGDEEWRAILSPEQFRILRQKGTEYPGTGEYVNFDKEGVYGCVGCNAPLYKSTTKFNAGCGWPAFFEGIPGAITRTTDPDGRRIEINCATCGGHLGHVFKGEGFATPTDERHCVNSVSLKFTPAASSL
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  Involved in cold tolerance.  Eliminates MetSO and reactive oxygen species that accumulate at the ER during cold acclimation.  MSRB family specifically reduces the MetSO R-enantiomer (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase B3, AtMSRB3, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.