PharMolix/UniProtQA huggingface dataset:
Protein: SUMF1_MOUSE
Sequence: MAAPAREPALRCCIRLARVFLLLVLACEVAGSDEAEAREGAASLAGSCGCGTPQRAGAHGSSAAAQRYSREANAPGLTSGPRPLALTKMVPIPAGVFTMGTDDPQIRQDGEAPARRVTVDGFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKTHIHQAVAAAPWWLPVKGANWRHPEGPDSSILHRSNHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGKFPVSNTGEDGFQGTAPVDAFPPNGYGLYNIVGNVWEWTSDWWTVHHSVEETFNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAD
What is the function of this protein?
Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent.  3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.  Known substrates include GALNS, ARSA, STS and ARSE.
What are the official names of this protein?
Formylglycine-generating enzyme, FGE, C-alpha-formylglycine-generating enzyme 1, Sulfatase-modifying factor 1.
What is the protein family that this protein belongs to?
Belongs to the sulfatase-modifying factor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RAPZ_YERPY
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPQLASTLADRNISAAVSIDVRNMPESPEVFEHAMTQLPDSFSPQLLFLDADRNTLIRRYSDTRRLHPLSAKNLSLESAIDEESDLLEPLRSRADLIIDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVISFLDRHTEVHNFIYQTRSYLEQWLPMLETNNRSYLTVAIGCTGGKHRSVYVAEQLADYFRARGKNVQSRHRTLEKRKQ
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: LACC1_CERUI
Sequence: AIGPVADIDIDVVSLGMVDQSLLREMHEVSNVALQAMKGSDEYDFNANLRLVLWNQPDFMWLR
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (Probable).  Oxidation of a broad range of substrates including mono-, di- and polyphenols, aromatic amines and methoxy-substituted phenols accompanied by reduction of oxygen to water.
What are the official names of this protein?
Laccase-C1, Benzenediol:oxygen oxidoreductase C1, Diphenol oxidase C1, Lac C1, Urishiol oxidase C1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATA_MAGSA
Sequence: MSKLTDLTMAEARDGLAKGAFTAVELTDAHIKATEAQRHLNAFIVETPDLALEAAKASDARRQAGTAGSMDGLPIGIKDLFCTEGVQTTAASHILEGFKPPYESTVSGKLKAAGAISLGKLNLDEFAMGSSNQTSYFGAVENPWKKTSDPKAKLVPGGSSGGSAAAVAARMVLGATGTDTGGSIRQPAAFCGITGIKPTYGRCSRFGIVAFASSLDQAGPMARTVRDCAIMLGAMAGHDPKDSTSVNMAVPDFERALTGDIRGLKVGIPKEYRPDGLSDEVAKVWDRGIEWLKAAGATPVEISLPHTKYALATYYIIAPAECSSNLARYDGLRYGLRVPGKTLDDMYKKSRAAGFGAEVRRRILIGTYVLSAGYYDAYYAKAQKVRRLIAEDFRKAFETVDVILTPTAPSAAFGMGEGTDDPVTMWLNDVFTIPTSMAGLPGLSLPAGLSADGLPLGLQLIGRPFDEETVFRVAGVMETAANFTAKPEGV
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: MPU11_ARATH
Sequence: MDYLGIDLSCAIGSLRNGEFPAKDCLLPLISKLLGYFLVAASMTVKLPQIMKIVDNKSVKGLSVVAFELEVIGYTISLAYCLNKDLPFSAFGELAFLLIQALILVACIYYFSQPLSVTTWVKAILYFAIAPTVFAGKIDPFLFEALYASKHLIFLSARIPQIWKNFRNKSTGQLSFLTCLMNFGGALARVFTSIQEKAPLSMLLGIVLSIFTNGIIMSQILLYRSKGNEDKLVKSKKIS
What are the official names of this protein?
Mannose-P-dolichol utilization defect 1 protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the MPDU1 (TC 2.A.43.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GPMI_RUEST
Sequence: MTTPKPVVLCILDGWGSAEPGPANAPYLAKTPTLDAIMQSCPTARLVTHGPDVGLPSGQMGNSEVGHTNIGAGRVVAMDLGQIDLAIEDGSFYDNDALQAFIAKLKETGGAAHLMGLVSDGGVHGHVTHILAAIKAIRDAGVPVWLHAITDGRDVAPKSALTYLDQLEAGMAPGAQIATVTGRYFAMDRDNRWERVSEAYDAMVKGAGQFTAATARDAVENAYGRDELDEFVKATVVEGFDGIKEGDGFFCLNFRADRAREILRAIGEPGFAEFDTGPRPALAALLGMVEYSEGHNAYMTTAYPKRAIVNTLGEWVAKQGKRQFRLAETEKYPHVTFFLNGGKETPEVGEDRFMPKSPKVATYDLQPEMSAPEVTAKFVEAIRAGYDLIVTNYANPDMVGHTGDLDAAIKACEAVDQGLGEVVAALKDAGGAMIVTADHGNCELMVDPETGGAHTAHTTNLVPVALVGGPEGTALKDGRLADLAPTLLALMGLDQPEEMTGESLLV
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: PURL_LATSS
Sequence: MVNNPTAIEIQQTKLYQQWGLTDSEYELICTKILKRLPNYTETGLFSVMWSEHCSYKNSKPILKKFPTNGPHVLQGPGEGAGILDIGDGQAVVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSMGATPIAILDSLRFGELNDNQTKYLVQEVVAGIGGYGNCIGIPTVGGEISFDPCYQANPLVNAMCVGLIEQKDIQQGKARGAGNSVLYVGAKTGRDGIHGATFASDEFAEGKATQRSAVQVGDPFMEKLLMDACLELILQHSDWLVGIQDMGAAGLVSSTAEMAAKAGTGMILDLDQVPQRETDMSAYEIMLSESQERMALCVRAGYEDQVIALFKGYDLDAVRIGEVTTKEQYQLWHQGQLVADLPVAALTDAAPVYHKDQAKPERLATFAAQAPYVPSVTDTQATWLALLKQPTIADKSSFYRHYDAQVKTNTVVLPGSDAAVVRIRGTKKALAMTTDCNGRYLYLDPHVGGQIAVAEAARNIVAAGGQPLGITDCLNYGNPEKPAVFWEFDQSAQGIAAACETFGTPVISGNVSLYNEFNGEAIYPTPMIGMVGLIRDIQDITTQDFKQVDDLIYLIGETDDNYAGSELQKMQQGTISDQLGHFSLATEKANQDLVLKAIQQGLITSAHDLSEGGLAVALSEATFKQGLGYHVQVDLASRQLFAETQSRFIVTVKAANQAAFEQISDQSAQLIGRVTAEPIMHIQTKDEMIDLTVEAAKDAWEAALPCLMKSEA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB_LEPIC
Sequence: MIINHNLSAVNAHRSLKFNELAVDKTMKALSSGMRINSAADDASGLAVSEKLRTQVNGLRQAERNTEDGMSFIQTAEGFLEQTSNIIQRIRVLAIQTSNGIYSNEDRQLVQVEVSALVDEVDRIASQAEFNKFKLFEGQFARGSRVASMWFHMGPNQNQRERFYIGTMTSKALKLVKADGRPIAISSPGEANDVIGLADAALTKIMKQRADMGAYYNRLEYTAKGLMGAYENMQASESRIRDADMAEEVVSLTTKQILVQSGTAMLAQANMKPNSVLKLLQQI
What is the function of this protein?
Component of the core of the flagella.
What are the official names of this protein?
Flagellar filament 35 kDa core protein, Flagellin class B.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: GPMA_BURCJ
Sequence: MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGRNEAYQAGELLKEAGYTFDIAYTSVLKRAIRTLWHVQDKMDLMYLPVVHSWRLNERHYGALSGLNKAETAAKFGDEQVLVWRRSYDTPPPALEPTDERAPFNDPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVRAGKQVLIAAHGNSLRALIKYLDGISDSDIVGLNIPNGVPLVYELDENLKPIKHYYLGDQEAIAQAQAAVAKQGKAG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: INS_LOPAM
Sequence: MAALWLQSFSLLVLLVVSWPGSQAVAPAQHLCGSHLVDALYLVCGDRGFFYNPKRDVDQLLGFLPPKSGGAAAAGADNEVAEFAFKDQMEMMVKRGIVEQCCHRPCNIFDLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LY6K_HUMAN
Sequence: MALLALLLVVALPRVWTDANLTARQRDPEDSQRTDEGDNRVWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRYCNLEGPPINSSVFKEYAGSMGESCGGLWLAILLLLASIAAGLSLS
What is the function of this protein?
Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity).  May play a role in cell growth (PubMed:18089789).
What are the official names of this protein?
Lymphocyte antigen 6K, Ly-6K.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Membrane raft.
Protein: UPP_DESVV
Sequence: MAVYVVDHPLVKHKLGRLRQHDVPVSEFRAIANELCRLLAYEATKDLETEKVSVQGWAGPVEVDQIKGKKITAVPILRAGLGMLDGFLDMIPGAKVSVVGMFRNEETLEPVQYYTKLAKNIDERMAVILDPMLATGGTLDATIDLLKNAGCPQIKGLFLVAAPEGLKRIVDKHPDVDIYVAAVDERLNEHGYILPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: NADK_CLOP1
Sequence: MRNIGIIINKEKDKENEILNLVILKVKEYLNPDEIKVIDQFYKGDYKDLMALDLLIVLGGDGTLLGVARKFSTVIDTPILGINIGNLGFLVTAEISELDEALYRIKVGDYKVEERMLLSCTIEGVTCSEERALNDIVVARGTLSRMAQYEVFINDELYATFKGDGVIISTPVGSTAYSFSAGGPLIMPDLQIVSIVPICPHTPNSRPMIIDGNNKVRVKPLINESDVFVTIDGQKALKLEKHNEVLIKKAKEFFRIISFDNKSYFKVLRKKLFKIE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLN_MOUSE
Sequence: MADVSERTLQVSVLVAFASGVVLGWQANRLRRRYLDWRKRRLQDKLATTQKKLDLA
What is the function of this protein?
Positively regulates mitochondrial complex assembly and/or stability (PubMed:29949756).  Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (By similarity).  Increases mitochondrial respiration rate (PubMed:31296841).  Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (PubMed:31296841, PubMed:32393776).  Increases mitochondrial calcium retention capacity (PubMed:29949756).  Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (PubMed:30796188).  Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:29949755, PubMed:32243843).  Not required for MTE formation or stability (PubMed:29949755).  Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843).
What are the official names of this protein?
Mitoregulin, Micropeptide in mitochondria, Micropeptide regulator of beta-oxidation, Small integral membrane protein 37, lncRNA-encoded micropeptide.
What is the protein family that this protein belongs to?
Belongs to the mitoregulin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids.
Protein: UN45B_HUMAN
Sequence: MAEVEAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQEKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGAEKIFQNNGVALLLQLLDTKKPELVLAAVRTLSGMCSGHQARATVILHAVRIDRICSLMAVENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHASTKLSRATFIITNGVSLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGTDYGLRQFAEGSTEKLAKQCRKWLCNMSIDTRTRRWAVEGLAYLTLDADVKDDFVQDVPALQAMFELAKAGTSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCMDYGFIKPVS
What is the function of this protein?
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain.  Plays a role in sarcomere formation during muscle cell development.  Is necessary for normal early lens development.
What are the official names of this protein?
Protein unc-45 homolog B, Unc-45B, SMUNC45.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage.
Protein: DNAJ_RICRO
Sequence: MSQNYYQILGVSKTASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKAINAAYDVLKDEQKRAAYDRLGHDAFQNQQSRGGGGNHGGFHPDINDIFGDFFSDFMGGSRRSSRPTSAKVRGSDLKYNLTINLEEAFHGIEKNINFSSAVKCDTCHGSGSEKGETVTTCDACSGVGATRMQQGFFTIEQACHKCQGNGHIIKNPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDITIKPHDIYKVDGANLHCKLPISFVNAALGGEIEVPVIEGGKVSLTIPAGTQNGDQLRLRSKGMSKMRSTIRGDMLTHIHVEVPKNLSKRQRELLEEFKKESINEKENDGSFFNKMKSLWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HV158_HUMAN
Sequence: MDWIWRILFLVGAATGAHSQMQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAA
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-58.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: AR6P1_DROME
Sequence: MAASQVDQKRALNKLKHDLEPFRTAIVGAYGVLTWEKQYYAGVVFGVISCLYLVLWYLDLSLITLLSLLGVISILLNYAFPMVSRLIFGGVNWDGDQEAKFEDVCGQVCAVKGSLVVWYEYLFNERKSTVFVIVMSLGLLAMAWIGAIINNLLLMYLATLLILMWPGLQNKDIFKAITQRASKIINEKIQCGKRKLQ
What are the official names of this protein?
ADP-ribosylation factor-like protein 6-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the ARL6ip family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RAD51_MOUSE
Sequence: MAMQMQLEASADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGYHTVEAVAYAPKKELINIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
What is the function of this protein?
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:15834424).  Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.  Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template.  Recruited to resolve stalled replication forks during replication stress.  Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR.  Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.  Also involved in interstrand cross-link repair (By similarity).
What are the official names of this protein?
DNA repair protein RAD51 homolog 1, RAD51 homolog A.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner. Colocalizes with ERCC5/XPG to nuclear foci in S phase. Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner.
Protein: KDSB_BLOPB
Sequence: MNFVVIIPVRFFSTRFPGKALADINGKPMIVRVMENALDSGANKVIIATDSSCIARVIESEQSESEVCLTRSTHQSGTERLAEVAINYKFSDDQIIVHLQGDEPLLSSTMIRQVASILCSMSSTISMATLATPLSSFKEARDDNVVKVVINMNSNALYFSRSMIPWNTGDFVNHLDSKFSKTLLRHIGIYAYRVKFLRRYIAWTKSPLEQIEHLEQLRVLWHGEAIHVSVIDDVFNISVDTPESLSRVNTVFKKNKYATVHN
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAL7_HUMAN
Sequence: MQKPCKENEGKPKCSVPKREEKRPYGEFERQQTEGNFRQRLLQSLEEFKEDIDYRHFKDEEMTREGDEMERCLEEIRGLRKKFRALHSNHRHSRDRPYPI
What is the function of this protein?
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters.  Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression.  Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
What are the official names of this protein?
Transcription elongation factor A protein-like 7, TCEA-like protein 7, Transcription elongation factor S-II protein-like 7.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7_CITK8
Sequence: MSITKDQIIEAVSAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKSLEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GBRA3_HUMAN
Sequence: MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
What is the function of this protein?
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.