PharMolix/UniProtQA huggingface dataset:
Protein: UPP_CLOK1
Sequence: MSKVTQITHPLILHKLALIRDKRTGSKDFRELVEEVAMLMAYEVTRNLQTEEVEIETPICNTTCKMLSGKKVAVVPILRAGLGMVGGMLKLIPAAKVGHIGLYRDETTLKPVEYFCKLPQDIGEREVIVTDPMLATGGSAIDAITMLKQKGAKNIRLMCLIAAEDGIKSVTEAHPDVDIYTAAIDKELNKNGYIVPGLGDAGDRLYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: TYW3_PONAB
Sequence: MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDGGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSVAIDAGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYTHKKKNPEKACAQCITKENDKELENDDDDDLGINVTIFPEDY
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 3 homolog, tRNA-yW-synthesizing protein 3, tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: GCH1L_STAAC
Sequence: MKIADLMTLLDHHVPFSTAESWDNVGLLIGDEDVEVTGVLTALDCTLEVVNEAIEKGYNTIISHHPLIFKGVTSLKANGYGLIIRKLIQHDINLIAMHTNLDVNPYGVNMMLAKAMGLKNISIINNQQDVYYKVQTYIPKDNVGPFKDKLSENGLAQEGNYEYCFFESEGRGQFKPVGEANPTIGQIDKIEYVDEVKIEFMIDAYQKSRAEQLIKQYHPYETPVFDFIEIKQTSLYGLGVMAEVDNQMTLEDFAADIKSKLNIPSVRFVGESNQKIKRIAIIGGSGIGYEYQAVQQGADVFVTGDIKHHDALDAKIHGVNLIDINHYSEYVMKEGLKALLMNWFNTEKINLDVEASTINTDPFQYI
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: RS13_CERS5
Sequence: MARIAGVNIPTAKRVPIALTYIHGIGNHVAEQICDAVGIDRARRVNQLSDAEVLAIREYIDANVTVEGDLRRETSMNIKRLMDLGCYRGLRHRRGLPVRGQRTHTNARTRKGPAKAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: IFNT1_SHEEP
Sequence: MAFVLSLLMALVLVSYGPGGSLGCYLSRKLMLDARENLKLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFPVLYEMLQQSFNLFYTEHSSAAWDTTLLEQLCTGLQQQLDHLDTCRGQVMGEEDSELGNMDPIVTVKKYFQGIYDYLQEKGYSDCAWEIVRVEMMRALTVSTTLQKRLTKMGGDLNSP
What is the function of this protein?
Paracrine hormone primarily responsible for maternal recognition of pregnancy.  Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium.  This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity.  This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus.  In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties.  In contrast with other IFNs, IFN-tau is not virally inducible.
What are the official names of this protein?
Interferon tau-1, IFN-tau-1, Antiluteolysin, Trophoblast antiluteolytic protein, Trophoblast protein 1, TP-1, Trophoblastin.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the uterine lumen.
Protein: FTSH1_ALKMQ
Sequence: MLKLTKKQLIIVLGIAIVVVSAIGYAVYTQYFNEDKLEISYTAFLESTEAGEIRTVNLSEGPKLTGVFEDGKQFITDHPRTDSLKENLLLHGIQVRETTDQYSVVQVITFVVLIGGFIGVAIFLSKKNATQTSKEYDKMSDVEFSTQKDSSIRFADIAGNQEAKENAMELVDFLKNPEKYSRYGAKMPKGVILYGSPGTGKTLLARALASEAGVEFLAVSGSDFVQVYAGLGAGRIRNLFKKAKDKGKCVIFIDEIDAIGKKRDRGGLGGSDESDRTLNALLTEMSGFKGSEGIIVMAATNRLDILDDALLRPGRFDRQIEIGLPDLKARQDILQLYTQNRPIDPKVCLRGIAQQTVYFSGAKLENLMNEAAIYAAREEADFITEGHIDKAFYTVVAGEEKKDRSNIQPIDRKITAYHEAGHAVATKLLCPQNKVTKVTIIPSTKGAGGFSMNIPPDQMYHTKNSMVNSIKVALSGRIIEEIVFGPDFVTTGASNDIQKATEILGAMIKQFGMNDEVGMINYDVLFGRQGACDQRVMELTKLNMKRLYDETKVLLEKSLNIVEAVAEDLLIKETLKEDEINEIFSGFQSM
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: PUR7_MYCSS
Sequence: MRPALSDYRHLASGKVRELYRIDDEHLLFVATDRISAYDHILSSEIPDKGRILTAMSVFFFDLIDAPNHLAGPPDDPRIPEEVLGRALVVRQLEMLPVECVARGYLTGSGLIDYRKTGTLCGLTLPPGLTEASKFAEPLYTPASKAELGLHDENIDFAATVDLVGEKRAAQLRERTLQIYTQGADHALTKGIIIADTKFEFGVDPSGELVLADEVFTPDSSRYWYADAYREGQVQPSYDKQFVRNWLTGPESGWDRAADQPPPPLPAEIVDATRSRYIEAYERISGLSFAEWIGASA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DEOD3_ALIF1
Sequence: MSTPHINAPLDAFADTILMPGDPLRAKLIAETYLENVVQVTDVRGMLGFTGEFKGRKISVMGHGMGAPSASIYFHELMTTYKVKNFIRIGSCGAIHDDVKLKDLIVAIGASTDSKMNRIRFKDNDFAATANYNMLSECVNTLKTTDINYLVGNVFSSDLFYRPDEEQYDMMARYGILGVEMEVNALYSAAAENHCNAVALCTVTDHIKNHEHLTADERRTELHEMINVALDVALKLPTE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PYRG_NEIG1
Sequence: MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRSQLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRKMPADERRKIALFCNVEERAIVGSYDVDSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAVKNPKHTVKIAMVGKYVDLTESYKSLIEALKHAGIHTETDVQITFVDSESIEKNKGDVSVLKDMDAILVPGGFGSRGVEGKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEWQTADGSVETRDESADLGGTMRLGAQEVELKAGSLAVKIYGSGHIRERHRHRYEVNNNYVSALEQAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALNNKKA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PRDX3_MOUSE
Sequence: MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.  Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity).  Required for the maintenance of physical strength (PubMed:27037278).
What are the official names of this protein?
Thioredoxin-dependent peroxide reductase, mitochondrial, Antioxidant protein 1, AOP-1, PRX III, Perioredoxin-3, Protein MER5, Thioredoxin-dependent peroxiredoxin 3.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner.
Protein: OB57B_DROME
Sequence: MFIYRLVFIAPLILLLFSLAKARHPFDIFHWNWQDFQECLQVNNITIGEYEKYARHETLDYLLNEKVDLRYKCNIKCQLERDSTKWLNAQGRMDLDLMNTTDKASKSITKCMEKAPEELCAYSFRLVMCAFKAGHPVIDSE
What is the function of this protein?
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
What are the official names of this protein?
General odorant-binding protein 57b.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
Protein: NPL1B_XENLA
Sequence: MANIDNKEQTELDQQDMEDVEDVEEEETGEEANSKARQLTAQMMQNPQVLAALQERLDDLVGTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHELERKYAALYQPFFEKRSDIINASYEPTEEECEWKVDEEEDIAEDLKEKAKLEEEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSEAGQPMNFMLEFHFEPNEFFTNELLTKTYKMRSEPDESDPFSFDGPEIMGCTGCLIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVPNDSFFNFFSPPEVPENGELDDDAEAILTADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADDEEGEEEADEDHDPDFDPKKAQNPAECKQQ
What is the function of this protein?
Acts as a chaperone for the linker histone to facilitate deposition of histone B4 onto linker DNA (PubMed:15928086).  Required for both remodeling of sperm chromatin into nucleosomes, and linker histone binding to nucleosome core dimers.  Plays a role in tissue-specific gene regulation.  Required for primitive hemopoiesis, acting upstream of tal1/scl (By similarity).
What are the official names of this protein?
Nucleosome assembly protein 1-like 1-B, xNAP1L-B, Nucleosome assembly protein 1, NAP1, xNAP-1.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic prior to the midblastula transition, becoming predominantly nuclear subsequently.
Protein: GLND_BRUAB
Sequence: MSAHDLKLEEIVNAETLRRKLNELADTADESYTSLPMRKVVLQTLKDALASGRANAEDMLMKDGGGTLCAKRLCYLMDTLIDILFEFATTRAYPTRNPSKAENMALVAVGGYGRGGLAQGSDIDLLFLLPYKQTPWGEQVVEYTLYMLWDMGLKVGHSTRNIDECIRLAREDMTIRTALLDARFLTGDKDLFRTLEIRFEEEIVKGTEPEFIQAKLAERDARHRKAGETRYLVEPNVKEGKGGQRDLHTLFWITKYFYRVKTKEELVKLGVLSRAELKLFNKAEDFLWAVRCHMHFATLKAEERLSFDIQPEIAQRLGYTAHPGQNYVERFMKHYFLVAKDVGDLTRIICAALEEQQAKHVPGFNRIFLTFSRRKRKLSDDGAFISENHRINIARPDIFRQDPVNMIRLFHLADRHGLEFHPEAMQSLTRSLKLINADLRENPEANRLFLEILTSPRNPELILRRMNESGVLGKFIPDFGKIVAMMQFNMYHHYTVDEHLLRCIAVLSEIEHGELKTEHPLSNHLITTIKRDRNLLYVTLLLHDIAKGRPEDHSIAGARIARRLCPRFGLTPSETETVEWLVREHLTMSMVAQSRDLNDRKTIIDFADTVQTMERLKLLLILTVCDIKAVGPGIWNGWKGQLLRTLFYETELVLTGGFSELSRAARDKQAREALAERLSDWPKEERDAYLALPYTNYFLTVSLDDQVRHAHFIRDADQQGRALVTMAKPHAFEAVTEITVLAPDHPRLLSVITGACAAAGGNIVDAQIFTTSDGRALDTILISREFDTDDDERRRAERVGKVIEDVLSGKAHLPDMLAKRTKPKKAARAFKVEPRVEINNTLSNKFTVIEVEGLDRPGLLSELTGLISDLSLDIASAHITTFGEKVIDSFYVTDLVGHKISNATRQGNIKRKLLALLGAENGARTNGRSPQAAA
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: DTD_HYDCU
Sequence: MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDDKMNLNLQQAFSGKGGDLLLVPQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLKFGPPQTGKFGANMQVSLINDGPVTFWLET
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_MAGSA
Sequence: MQTANEIRRTFLDFFEKNGHTVVNSSPLVPRNDPTLMFTNAGMVQFKNVFTGIEKRDYVRAASSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKDLAIEHAWNLITKDFGIDKSRLLVTVYHDDDQAADAWKKIAGLPESRIIRIPTSDNFWAMGDTGPCGPCSEIFYDHGEHIFGGPPGSPDQDGDRFIEIWNLVFMQFEQVDKETRIPLPKPSIDTGMGLERLAALLQGKHDNYDVDLLRALIEASAEASNTDPDGPHKVSHRVVADHLRSSSFLIADGVLPSNEGRGYVLRRIMRRAMRHAHLMGCTEPLLHKLVPALTRQMGEAYPELVRANALITETLKLEETRFKVTLDKGLKLLDDEITRIGSGQKLAGEVAFKLYDTYGFPLDLTQDALKAKGIGVDTDGFASAMERQRAEARKAWAGSGDTATETVWFELREKLGASEFLGYDAEQAEGKIVALVENGKVVEAVHPGHQVAVIANQTPFYGESGGQMGDTGVITLGTPGTGGKATIAVTDTQKKLGDLIVHFGTVEGGPVAVGEDAHFAVESTRRDATRGHHSATHLLHAALRDILGDHVTQKGSQVGPDRLRFDFAHTKALSAEETRAVEAEVNRRIRLNAEVATKVMTPDDAIKAGAMALFGEKYGEEVRVVSMGDLSTELCGGTHANRTGDIGGFKIVAESAVASGVRRIEAVTGPAFLAWAQAQEDLLAKAADTLKAAPADLPARIAGLMDDRRKLERELAEVRKQLATGGGQGAATKTVNGITYAGKVLSGVPAKDLKGMADEIKKQIGSGIIALVSDADGKASIVVCVTEDLTSKHSAVDLVRIGSEALGGKGGGGRPDMAQAGGPDASAAQAAVDRIEQALGG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STXA_BP788
Sequence: MKIIIFRVLTFFFVIFSVNVVAKEFTLDFSTAKTYVDSLNVIRSAIGTPLQTISSGGTSLLMIDSGTGDNLFAVDVRGIDPEEGRFNNLRLIVERNNLYVTGFVNRTNNVFYRFADFSHVTFPGTTAVTLSGDSSYTTLQRVAGISRTGMQINRHSLTTSYLDLMSHSGTSLTQSVARAMLRFVTVTAEALRFRQIQRGFRTTLDDLSGRSYVMTAEDVDLTLNWGRLSSVLPDYHGQDSVRVGRISFGSINAILGSVALILNCHHHASRVARMASDEFPSMCPADGRVRGITHNKILWDSSTLGAILMRRTISS
What is the function of this protein?
The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits.  After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits (By similarity).
What are the official names of this protein?
Shiga toxin subunit A.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family.
Protein: Y289_RICPR
Sequence: MNNIFGFFKSSNNTQSASGGKQNQENIKSANPLKISQNWYEERSDKLIVQRNLLIILIILLTIFMVISTLVIAFVVKSKQFDPFVIQLNSNTGRAAVVEPISSSMLTVDESLTRYFIKKYITARETYNPVDFATIARTTVRLFSTSAVYYNYLGYIRNKDFDPTLKYKEDNTTFLVIKSWSKIADDKYIVRFSVNETSGSQLVYNKIAVVSYDYVPMQLTDSELDINPVGFQVNGYRVDDDNS
What are the official names of this protein?
Uncharacterized protein RP289.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ECFA2_MYCPN
Sequence: MKKIVELKNPLRDGEILSVSNLSCFFNEKTVHEVKVIDNFSYTFAKNKVYCIIGDSGSGKSTLVNHFNGLIKPAYGDIWVKDIYIGQKQRKIKDFKRLRKTISIVFQFPEYQLFKDTVEKDIMFGPIALGQSKNEARQKAAYYLEKMGLKYTFLERNPFELSGGQKRRVAIAGILAIEPEVLIFDEPTAGLDPEGEREMMRLIKDAKASGRTVFMITHQMENVLEVADEVLVLSKGQLVKSGDPYEVFMDEAFLAHTTIIMPPVIQVIKDLINLNPKFSCLLDFKPRNLDQLADAINNTIAHG
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GRPE_PSEFS
Sequence: MADEQTQDTQTPDANSAVGDELATRVQVLEEQLAAAQDQSLRVAADLQNVRRRAEQDVEKAHKFALEKFASDLLPIIDSLERGLELSNPDDENIRPMREGIELTLKMFQDTLKRYQLEAIDPVGGEPFNAEHHQAMAMQESHDLEPNSVLKVFQKGYQLNGRLLRPAMVVVSKAPAPVSPSIDEQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_SHISS
Sequence: MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMC1_DANRE
Sequence: MPRHKLIASESDVSIEVDEGKDKESCVYYVEVEENCERGKIKQASRDGKRRRERNGETRRKASEKRTNEGESKKAEKKHEKGHRTARKAGEKHGKRQRRKNAGEEDAEDKSSKEKKNMKNEKNKTLKLEEEKEKDVRKKKRKHVKNEEDETNHEKTKQHLKEEKRRKKRKKPETTSESESKSESESASESESKNSPAVGVLGSLTPEELENLKEAVEERKKLITQLKGKPWPMRRKLVVLRESQEFVEKYEGALGKGKGRKLYAYKVMMMKKWMKFQRDFENFKTACIPWEMKIKEIESHFGSSVASYFIFLRWMYGINMILFGLTFGLVMVPEALMGKPYGSLPRKTVPREEEASAMNFAVLWDFGGYAKYSVLFYGYYNSQRAIGWLKFRMPLSYFLVGVGTVAYSYMVVIRTMARNANEEGGGDDTSFNFSWKTFTSWDYLIGNPETADNKFASITTSFKEAIVEEQESRKDDNIHLTRFLRVLANFLVLCCLAGSGYLIYFVVRRSQKFALEGLENYGWWERNEVNMVMSLLGMFCPMLFDVISTLENYHPRIALQWQLGRIFALFLGNLYTFIIALMDAIQLKRAEEEIVKKNMTIWQANLYNGTVPDNSTAPPLTVHPADVPRGPCWETMVGQEFVRLIISDTMTTYITLLIGDFMRAVLVRFLNNCWCWDLEYGFPSYSEFDVSGNVLGLIFNQGMIWMGAFYAPCLPALNLLRLHVSMYLQCWAVMCCNVPQERVFKASGSNNFYMAMLLVILFLSTLPAIYTIVSIPPSFDCGPFSGKPRMFDVIQETLETDFPAWFSKVFSYASNPGLVLPFLLLLVLAIYYLQSTSKTYKRVNMELKKKLQAQNEENKKKNKLAALKAASDLEQARKAGEQRRNSISDLGVNEENPESHVSSSHTSRPPASRGHTSSGHLPGHPQQPQKNSKKR
What is the function of this protein?
Probable ion channel required for the normal function of hair cells (By similarity).  Component of the hair cell's mechanotransduction (MET) machinery (PubMed:25114259).
What are the official names of this protein?
Transmembrane channel-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the TMC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localized to the hair bundles of the hair cells.
Protein: EFNB3_HUMAN
Sequence: MGPPHSGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEGPLPPPSMPAVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPREAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV
What is the function of this protein?
(Microbial infection) Acts as a receptor for nipah virus and hendra virus.
What are the official names of this protein?
Ephrin-B3, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8, LERK-8.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ZFOI1_MOUSE
Sequence: MVRRRQRLPEVDMGLVSFEDVAVDFTWQEWQELDAAQRTLYRDVMLENYRSLVWLGHCLAKPELISKLEEGFEPWGVAEATEQCLPGVRKWSAPVEKGQQSQEKYLRQVKIIKKNTPDEDKVEVENTYNVDSNCISNMTLKNEVCSRVFFQELVNPLLDVPLPTEAGERQSTEVPHDLNRTQEVLSYPKHFTHHSKDQYSQCCFQYFGPDEAFHTKAILTPEMFYVQETSRTCNNYDKSFDEVTIPAQYMTQLRKQTLGWNICHKIFPNKTELSNHDAMHTGENDDKCDYEKPIINKSLYLTKHQEAHAGIEPQAHKENIKFFCLDAELQTVDPELHGEKQVYECKVSGKTFRHQPEHISQQRPHACERACQAKEHGEAGCDEPALTQHQRLCTEEKACEGKACSKAFHHKSLLPQYQSARADEQQSDCKELMKIYFYVSSPTQHHGPPPPEKPFRCNDCLKTFSHKSQLERHQRMHTGEKPHECKECRKAFCHKSHLIRHQGIHAPEKPYECNECKKSFYLRSQLTLHERTHTGEKPFECKECRKAFSRNSHLTQHQKIHTGEKPHKCKECGNAFARKSHLIQHQKTHTGERPYECKECRKAFSRKSQLMQHETTHTGERAYECKECRKTFYLKAYLTRHQVIHQSEKPFECKKCGKAFSRKSYLTRHQKIHKGQTLSG
What is the function of this protein?
May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation.
What are the official names of this protein?
Zinc finger protein OBI1, Osteoblast inducer-1, ObI-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSCA_VESOH
Sequence: MTLLQISEPSQVSKPHQHKLVIGIDLGTTNSLVASVINGQSKVIMDENNEAVLPSIIHCGKHNKLTVGCDAYPYAKTDPTNTIISIKRFMGMSYEEVSTFKNCPYQLIKDGNNVLFHTSMGNLSAVEISASILSSLKQRAENSLGGVLSGAVITTPAYFNDAQRQATKDAATLAGLKTLRLLNEPTAAAVAYGLESGEEGVHAIYDLGGGTFDISILNFSKGVFKVLAIGGDATLGGDDFDELIINDCIEQLSINELTPAQMQEIKQFSRIAKETLSNYEFSEFDCIKRPYCITKKKFETLAKVLIKRTLLLTKQAIRDAQVDVKNIKNIIMVGGSTRIPLVCSMVSDLFNKPVLCSINPDEVVAKGAAIQANILAGIKSQNDILLLDVLPLSLGLETMGGLVEKIIHRNTTIPIIRAQEFTTFKDGQTAMSIHVLQGERELVRDCRSLAKFDLYGIPAMVAGNARIRIEFQVDVDGLLSVSAVEQISGVKTNISIKPSYGLTDVQKEKMLKDSFLFAKTDIQTRKLHETQVEANRTIEAIDSAIKKDKNMLDDKMLNNILNARNTLFDIVHSDDEKAISIAIENLENSCLKFVEMRMNSSVMKAIQGRNIDEF
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.