PharMolix/UniProtQA huggingface dataset:
Protein: HOA2_DECAR
Sequence: MTLKGKKVTVHDMTLRDGMHPKRHLMTLDQMTAIATGLDAAGVPLIEVTHGDGLGGSSVNYGFPAHTDEEYLGAVIPKMKNAKVSALLLPGIGTVDHLKMARDLGVHTIRVATHCTEADVSEQHITMARKLEMDTVGFLMMAHMNSAEGLVKQAKLMESYGANCIYVTDSAGHLLPEGVKERLSAVRAALKPETELGFHGHHNLAMGVANSIAAIEVGANRIDAAAAGLGAGAGNTPMEVLIAVCSLMGIETGVDVAKITDVAEDLVVPMMDFPIRIDRDALTLGYAGVYGSFLLFAKRASAKYGVPARDILVELGRRGMVGGQEDMIEDTAITMARERGV
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: YCF15_SPIOL
Sequence: MLLLKHGRIEILDQNTMYGWYELPKQEFLNSEQPEPITHSIKKFPLMKDVNPLENQKYACLMK
What are the official names of this protein?
Putative uncharacterized protein ycf15, ORF 63.
What is the protein family that this protein belongs to?
Belongs to the ycf15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL34_CLOBA
Sequence: MFMTYQPKKRQRKKEHGFRKRMSTQSGRNILRKRRQKGRKKLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ATP8_NEUCR
Sequence: MPQLVPFYFVNEITFTFVIITLMVYILSKYILPRFVRLFLSRTFISKLSDISKK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: HIS7_METVS
Sequence: MRAFKVKRDTNETKIHLELNIDGTGKYSINTGIPFFNHVLSSFAKHGAFDVILDVLGDLEIDDHHTVEDTGIVLGKAFESIEKNNIKRFGFAIIPMDEAKATVTIDIGGRPYLVGKYNPNTEKIGNFSTENVVHFFESFSNNAKVNMHFEVTGENEHHKVEALFKAFGIAMDMATQPDERKGIVSTKGII
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_LEGPL
Sequence: MSQRKYFGTDGIRGHVGLSNINPEFVLKLGWAVGCVLANGARKKVVIGKDTRVSGYMLESALEAGLSAAGVDVALLGPMPTPGIAYLTQTLRANAGIVISASHNLFEDNGIKFFSADGGKLPDSVELAIEAQLEKQLQTVPSAKLGKATRINDAAGRYIEFCKSTIPSLSRLSNLKIVVDCANGATYHIAPNVFSELGADVVPIGIKPDGFNINQECGSTAPELLREKVIAVGADIGIGLDGDGDRVILVDSLGNLVDGDQIIYIIAKDRHQRGVLHGGVVGTLMSNYGLELAITSLGVPFQRSKVGDRYVLEMLREKDWKIGGETSGHIVCLDKTTTGDGIVAALQVLSIMVKQNKALHELTAGIQLLPQTLVNLKTNNAALLASNPDVIQAVKNLEKHLNGEGRVLLRPSGTEPLLRVMVEGANASIVKQQAQMLCDDISQIDKKMTESLPST
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RPOB_PAEAT
Sequence: MEGSLLVASSTSNNETANTASTDGATRRLSFAKIHEPLDVPNLLALQTDSFDWLVGNERWQARVAKAVEEGDLSVATTSGLADIFEEISPIEDFQGTMSLSFSEPEFADPKYTMAECKDRDATYSAPLYVKAEFMNNNTGEIKQQTVFMGDFPLMTEKGTFVVNGTERVVVSQLVRSPGAYFERTADKTSDKDIFTAKIIPSRGAWFELEIDKRDQVGVRLDRKRKQSVTVLLKALGWTEGQILEEFGQYDSMRATLEKDATETREDALLDIYRKLRPGEPPTVEAAQSLLDNLYFNAKRYDLAKVGRYKINRKLGIDRSLGDKEASVLHVEDIVAMIKFLVALHAGEKTLMGKRDGEDHELRVDVDDIDHFGNRRIRAVGELIENQVRTGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRDRAGMEVRDVHPSHYGRMCPIETPEGPNIGLIGSLASYGRINPFGFIETPYRLVSEGVVSDEVQYLTADDEAEVLIAQANAPLDADKKFSEETVLVRARGGGGEPVLVPAADVQFMDVSPRQMVSVATALIPFLEHDDANRALMGANMQRQAVPLVRSEAPFVGTGMERAAAVDAGDVVIAKKAGVVTEVSAELVVMINDDGTETNYRINKFARSNQGNCYNHRVLVNEGQRLEVGGIIADGPATDQGELALGKNLLVAFMSWEGHNFEDAIILSQRIVAEDVLSSIHIEEHEIDARDTKLGAEEITRDIPNVSEEVLAGLDERGIIHIGAEVEAGDILVGKVTPKGETELTPEERLLRAIFGEKSREVRDTSLKVPHGESGTVIGVRVFDRDNDDELPPGVNQLVRVYVAAKRKITDGDKLAGRHGNKGVISKILPIEDMPFLADGTPVDIVLNPLGVPGRMNVGQVLETHLGWVAKTGWKIEGEPEWVKNLPNLPRETGQTTVATPVFDGAREEEITGLLDSTNVTRDGDRLIDSSGKTRLFDGRSGEPFPDPISVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQELLTIKSDDIHGRVKVYEAIVKGENIPEPGVPESFKVLIKEMQSLCLNVEVLSTDGTTIEMRDSDDAVFTAAEELGIDLSRAEPSSVEEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CSN5_CRYNB
Sequence: MASTARKTFEINNNVQVVDPSAAIFQYSREEEKLLDDEAPWRTDPHYFHTVKISAVALIKMVTHARSGGIYEIMGIMYGKVRDGTFWIMDVAALPVQGTETRVNAGNEAMEYMVNFQTANAEAGKGELLRGWYHSHPGYGCWLSGIDVNTQLNNQKFNDPYLAVVIDPNRTVSAGKVEIGAFRTYPEGYTPPATGNSQYQSIPMDKIEDFGVHANAYYPLKVEIYKSKLDEKMLDLLWNKYWVATLSSNSLVSNLEYSTSQVQDLNAKLRAASQSISNSSSKLKLKPTQPTTKGKETTEGSDKKLKKGEKEFSGVEEEETPLNKVTQESSRITSEAENGIISQLLKEKLFNTPLTQSVDDKSAQATVQGRY
What is the function of this protein?
Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
What are the official names of this protein?
COP9 signalosome complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RRAAH_RALSO
Sequence: MMIPVTDLCDAHEDQLASGAVRVLAPVFRSFGARAAFAGPAATLKVFEDNGLVRAMLEQPGEGRVLVVDGGGSLRCALVGGNLAKLAEDNGWEGVLVNGCVRDTRELAACNVGVHALAAHPRKSFKKNQGERDIGVQMPGAYIHPGEWIYGDEDGVLVSRERLHD
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: TYSY_MYCPA
Sequence: MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDSIFDYTYDDVVVHNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_MARMM
Sequence: MRCPFCGHPDTQVKDSRPAEDGNAIRRRRQCPSCAARFTTFERVQLRELTVMKKSGRRVPFDREKLNRSIQLAMQKRNIEPDRIDQMISGIVRRLESTGETDVTSDRVGELVMEGLKNLDAVAYVRYASVYKDFHKVEDFREFITDEALTAHFGPREDDDG
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: Y1463_METTH
Sequence: MEVFVMSTSLGDEVIVMQSRSYSCGPAALATVLRNLGVNCTEAELAELAGTDESGTTMYGLIVAATSKGLRARGVKMELNDLRKNHIVFVKYGDTCHYTVIMSMDERNVTLADPALGRITVKREIFSRIFTGNVLVVERPCD
What are the official names of this protein?
Uncharacterized protein MTH_1463, ORF11.
Protein: RBSD_PETMO
Sequence: MKKQGIFNSQISYFVASMGHKDMLSIVDMGYPIPKDATFVDLVFDKGIPNFIDTIKMVLYELEVEKVIIAGEMEVNNLKNYQKVIDIFSNIEIEKKSHEEFKDIAKNSKFFIRTGECTPFSNIILVSGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCED3_ORYSJ
Sequence: MATITTPGYAHIQRQHGRCSTTAGRRGASNSVRFSARAVSSVPHAAAASSAPAFLPVPFVPGADAPSPSGKSAIGVPKAPRKGEEGKRLNFFQRAAAMALDAFEEGFVANVLERPHGLPSTADPAVQIAGNFAPVGETPPARALPVSGRIPPFINGVYARNGANPHFDPVAGHHLFDGDGMVHAVRIRNGAAESYACRFTETARLRQERAMGRPMFPKAIGELHGHSGIARLALFYARAACGLLDPSHGTGVANAGLIYFNGRLLAMSEDDLPYQVRVTADGDLETVGRYDFDGQLGCAMIAHPKLDPATGELHALSYDVIKKPYLKYFYFAPDGTKSADVEIPLDQPTMIHDFAITENYVVVPDHQVVFKLQEMLRGGSPVVLDKEKTSRFGVLPKHAADASEMVWVDVPDCFCFHLWNAWEEADTDEVVVIGSCMTPADSIFNESDDRLESVLTEIRLNTRTGESTRRAILPPSSQVNLEVGMVNRNLLGRKTRYAYLAVAEPWPKVSGFAKVDLATGELTKFEYGEGRFGGEPCFVPMDAAAATPRGEDDGYILSFVHDERAGTSELLVVNAADMRLEATVQLPSRVPYGFHGTFITGDELTTQA
What is the function of this protein?
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity.  Catalyzes the first step of abscisic-acid biosynthesis from carotenoids.
What are the official names of this protein?
9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic, OsNCED3.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TESK1_HUMAN
Sequence: MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
What is the function of this protein?
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity).  Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity).  Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity).  Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898).  Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).  Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
What are the official names of this protein?
Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (PubMed:15584898). Localized to F- actin-rich lamellipodia at the cell periphery following fibronectin- mediated cell adhesion of Schwann cells (By similarity).
Protein: FKBP_ASPOR
Sequence: MGVERKIITRGSGPSPASGDKVSIHYTGWIYDPKKANKGFQGKQFDSSRSPGRGPLVVNIGQGKVIKGWDEGVMQMSLGEKSTLTITPDYGYGDKAAGKIPANSTLIFEVELLKIN
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 1, FKBP, Peptidyl-prolyl cis-trans isomerase, PPIase, Rapamycin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3944_LYSSC
Sequence: MSFRGKRMKNVANQRYYLVREDVLTDAMQKTLEAKHLLSSGSVSSIWDAVKQVDLSRSAFYKYRDAVFPFHSIVQERILTVFLQLQDRKGTLAKLLETVTITHCNVLTIHQTIPIQGRANVTLSLDVTSMTCDLDDLIQQLKRLDFVESAEVISSGAL
What are the official names of this protein?
UPF0735 ACT domain-containing protein Bsph_3944.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: CD47_MOUSE
Sequence: MWPLAAALLLGSCCCGSAQLLFSNVNSIEFTSCNETVVIPCIVRNVEAQSTEEMFVKWKLNKSYIFIYDGNKNSTTTDQNFTSAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNR
What is the function of this protein?
Adhesive protein that mediates cell-to-cell interactions (By similarity).  Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity).  Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:20610415, PubMed:23591719).  Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621).  Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415).  Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).  Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).  Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity).  Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238).  Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764).  In response to THBS1, negatively modulates wound healing (PubMed:18156939).  Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719).  May play a role in membrane transport and/or integrin dependent signal transduction (By similarity).  May prevent premature elimination of red blood cells (PubMed:10856220).
What are the official names of this protein?
Leukocyte surface antigen CD47, Integrin-associated protein, IAP.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NS1_I91A0
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQELGDAPFLDRLRRDQKSLKGRGSTLGLDIETATRAGKQIVEQILEEESDEALKMTIASVPASRYLTDMTLDEMSRDWFMLMPKQKVTGSLCIRMDQAIMDKNIILKANFSVIFERLETLILLRAFTEEGAVVGEISPLPSLPGHTNEDVKNAIGVLIGGLKWNDNTVRISETLQRFAWRSSHENGRPSFPPKQKRKMERTIEPEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: ADH1_EMENI
Sequence: MSIPTMQWAQVAEKVGGPLVYKQIPVPKPGPDQILVKIRYSGVCHTDLHAMMGHWPIPVKMPLVGGHEGAGIVVAKGELVHEFEIGDQAGIKWLNGSCGECEFCRQSDDPLCARAQLSGYTVDGTFQQYALGKASHASKIPAGVPLDAAAPVLCAGITVYKGLKEAGVRPGQTVAIVGAGGGLGSLAQQYAKAMGIRVVAVDGGDEKRAMCESLGTETYVDFTKSKDLVADVKAATPDGLGAHAVILLAVSEKPFQQATEYVRSRGTIVAIGLPPDAYLKAPVINTVVRMITIKGSYVGNRQDGVEALDFFARGLIKAPFKTAPLKDLPKIYELMEQGRIAGRYVLEMPE
What are the official names of this protein?
Alcohol dehydrogenase 1, Alcohol dehydrogenase I, ADH I.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted.
Protein: GSA_PROMS
Sequence: MTDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTALQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLLVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLELLKQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAPSPFEAGFTSLAHSEEEIDKTIEAFDESFNAIKK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_DESVM
Sequence: MAKAIKKVVLAYSGGLDTSVILKWIAVTYGCEVVTLTADLGQEEDLDGVDAKALRTGASRAYVEDLREEFARDFIFPMMRSGAVYEGRYLLGTSIARPLIAKRLVDIARAEGAQAVAHGATGKGNDQVRFELAVNALAPDLDVIAPWRIWDLRSRTDLTAFAEQHGIPLSTSSKQYSMDRNMLHCSFEGGELEDPWCEPGPNSHVMAVPVEQAPDTPEYITIEFKKGDAVAVNGEAMSPASIIRTLNTIGGRHGIGRLDMVENRFVGIKSRGVYETPGGTVLHIAHRDLEGICMDRESMHLRDQLIPRYSEAVYNGFWFAPEREAMQAFIDKTQETVNGTVRLKLYKGNAYPVGRTSPNTLYCHDLATFEDCATYDHADAAGFIKLQGLRVRGYAQRVKKD
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACER2_MOUSE
Sequence: MGAPHWWDHLRAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAILWVLMCALAMWFPRRYLPKIFRNDRGRFKAVVCVLSAITTCLAFIKPAINNISLMILGLPCTALLVAELKRCDNVRVFKLGLFSGLWWTLALFCWISDQAFCELLSSFHFPYLHCVWHILICLASYLGCVCFAYFDAASEIPEQGPVIRFWPSEKWAFIGVPYVSLLCAHKKSPVKIT
What is the function of this protein?
Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:29401619).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:29401619).  Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (By similarity) (PubMed:29401619).  Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates.  Also hydrolyzes dihydroceramides to produce dihydrosphingosine (By similarity).  It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (PubMed:29401619).  Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate.  As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage.  Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (By similarity).
What are the official names of this protein?
Alkaline ceramidase 2, AlkCDase 2, Alkaline CDase 2, maCER2, Acylsphingosine deacylase 3-like, Cancer-related gene liver 1 protein, CRG-L1, N-acylsphingosine amidohydrolase 3-like.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.