PharMolix/UniProtQA huggingface dataset:
Protein: UPP_THEP3
Sequence: MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPVAVAKTKVIAGKKLGIIPILRAGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVNLIAAPEGIEAVHRDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: CYCR_CLITE
Sequence: GIPCGESCVFIPCTVTALLGCSCKDKVCYKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide cter-R.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CUTC_CHRVO
Sequence: MDKILEICAGSLASCIAAQEGGAQRVELCDNLGEGGTTPSYGALAMARGRLNIALHAIIRPRGGDFLYSALEFDAMAHDVEVCRSLGLDGVVLGLLTADGDVDVARTRQLAALAGPMAVTFHRAFDLAREPEQALEDVIAAGCSRLLSSGQAASAPEGAALLARLREQAGGRLTVMPGAGVRPGNIAGLAAASGCIEFHASARGQVASAMRYRRGGVGMGASGVDEYARQETSASQVRALREALDKA
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_STAAN
Sequence: MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: VPX_SIVV1
Sequence: MASGRDPREERPGGLEIWDLSREPWDEWLRDMVEEINNEAKLHFGRELLYQVWNYCQEEGERQGRPIAERAYKYYRLVQKALFVHFRCGCRRRQPFEPYEERRNGQGGGRPGRVPPGLD
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: DABB2_HALNC
Sequence: MTIEFSHTTGLLLLAMPALLLMAAVIKPKQGAAYARAYRQRVQWTSFAAFGLALLAVVSFLFARQQNLMLGAGSLPAGLGLLALSIQVNGLTLVLASLVSFVLSVIARYSVQYLDGDPQQARFFRLLAVTGGFFLLVVISGNLGLFTLAIIATGFGLHRLLSFYADRPRAIMATHKKSIFSRTADALLLAATVLIGHQIGSLEFSQISAYVHAQDHLSIALHVAAWLIVLAAILKSAQFPFHGWLIQVMEAPTPVSALMHAGVVYSGAIIVLRTSELLAADGTALLLLALIGLMTLAIGSLVMLTQSAIKSSLAWSTAAQLGFMMLELGLGLFGLALLHLVGHSLYKAHAFLSSGSMTDHLRQAKVLKNRPISVVAWFTTVIVSGLFTLGIAAAMGLSIDQEPMLPAVLTIIALATAQLMLKALSHGTWREILVAAGAAIAMTGVYVFLHEVFITGFADTLAATPQRAPLLDLLLMAITIITFLFVAWLQGPGKTLMSPERQFALFVHLNNGLYLDRWVERLAFRFWPEKVGRAPKKSCAVIPPNPSGIEP
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump; its substrate may be carbon dioxide.  Expression of both dabA2 and dabB2 (DAB2) restores growth in ambient air to E. coli deleted of its carbonic anhydrase genes (called CAfree, deletion of 'can' and 'cynT'); neither dabA2 or dabB2 alone is sufficient.  Rescue is pH-independent, suggesting it transports CO(2) and not carbonate ions.  Together the genes allow greater than normal uptake of inorganic carbon by E. coli (PubMed:31406332).  Uptake of carbon dioxide rather than bicarbonate has been suggested based on kinetic calculations (Probable).
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabB2.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPE69_MYCTU
Sequence: MPDPGWAARTPEANDLLLTAGTGVGTHLANQTAWTTLGASHHASGVASAINTAATAASWLGVGSAASALNVTMLNATLHGLAGWVDVKPAVVSTAIAAFETANAAMRPAPECMENRDEWGVDNAINPSVLWTLTPRIVSLDVEYFGVMWPNNAAVGATYGGVLAALAESLAIPPPVATMGASPAAPAQAAAAVGQAAAEAAAGDGMRSAYQGVQAGSTGAGQSTSAGENFGNQLSTFMQPMQAVMQAAPQALQAPSGLMQAPMSAMQPLQSMVGMFANPGALGMGGAAPGASAASAAGGISAAATEVGAGGGGAALGGGGMPATSFTRPVSAFESGTSGRPVGLRPSGALGADVVRAPTTTVGGTPIGGMPVGHAAGGHRGSHGKSEQAATVRVVDDRR
What are the official names of this protein?
Uncharacterized PPE family protein PPE69.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: AGL8_HALVD
Sequence: MADQRNQADKPTTRIPDDEWEAIVANVPLVSVDLVIRHEGGVLLGFRENEPARGEWFVPGGTVFKNETLTDALYRVADEELGVDVTIESRLGTFEHFYDTSDVEGIDSKHYLATAFEVTLDDDNLEMDTQHSQLKVFEPPYEGLHPYVERYLDALD
What is the function of this protein?
Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1. 75 M instead of 3. 4 M).  Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose.  Mediates attachment of sugar 3 in the tetrasaccharide.
What are the official names of this protein?
Low-salt glycan biosynthesis protein Agl8.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: BIOB_SALEP
Sequence: MARHPRWTLSQVTELFEKPLLELLFEAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLDSARKAKNAGSTRFCMGAAWKNPHERDMPYLEQIVQGVKAMGLETCMTLGMLNESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVREAGIKVCSGGIVGLGETVTDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPAEDKDLQLFRKLGLNPQQTRVLAGDNEQQQRLEQTLMTPDTDDYYNAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: I2B2_CONLT
Sequence: MMFRLTSVSCFLLFIVFLNLVVLTNACIPEGTYCQFNADCCLSQCCWGSCGNPCRFPGKREKLQEFFRQR
What are the official names of this protein?
Conotoxin Lt11.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CHRD_HUMAN
Sequence: MPSLPAPPAPLLLLGLLLLGSRPARGAGPEPPVLPIRSEKEPLPVRGAAGCTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPACGQPRQLPGHCCQTCPQERSSSERQPSGLSFEYPRDPEHRSYSDRGEPGAEERARGDGHTDFVALLTGPRSQAVARARVSLLRSSLRFSISYRRLDRPTRIRFSDSNGSVLFEHPAAPTQDGLVCGVWRAVPRLSLRLLRAEQLHVALVTLTHPSGEVWGPLIRHRALAAETFSAILTLEGPPQQGVGGITLLTLSDTEDSLHFLLLFRGLLEPRSGGLTQVPLRLQILHQGQLLRELQANVSAQEPGFAEVLPNLTVQEMDWLVLGELQMALEWAGRPGLRISGHIAARKSCDVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRDQRTVLCHMAGLQPGGHTAVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAALPYCGHSARHDTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGTPGPRRLLKGFYGSEAQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVHIANQCEVGGLRLEAAGAEGVRALGAPDTASAAPPVVPGLPALAPAKPGGPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVRDLPGLPRSRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRGCRFAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGSGKESRCCSRCTAHRRPAPETRTDPELEKEAEGS
What is the function of this protein?
Dorsalizing factor.  Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).
What are the official names of this protein?
Chordin.
What is the protein family that this protein belongs to?
Belongs to the chordin family.
What are the subcellular locations of this protein?
Secreted.
Protein: T2R14_HUMAN
Sequence: MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 14, T2R14, Taste receptor family B member 1, TRB1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HELB3_ASPFU
Sequence: MAVATLISILFAVLALRLCYLLIHALFLSPLRHIPAPFMARVTSKRPLWHLLTGKAEIAARQDYSTFGDIYLCKPNTVYLCDPHDACTVLSSHAFRKTDMYRVFEYEGIPNVSTFTDPAQAQRRRRQLHPFFNNAYLTQMEPVMLKYGIQALKARWDAQLARHKKVEVNYRFDTQLAMFDITGALVFGREFHALETSNLVYTKWVNNTLSYMLVSHYFPWVKRVPLSWLVRGLKQSYDDLVAFSQESIAIRQADLQAGRPKPADLLQALLDAEDPDSKAPMTAREVQAESIAMLVGGSESTSSVISWVIHFLLLYPEHLQAVVAETRANFPADHTITFNESKANLPYLEACIYETLRCIPTASTSFPRVSDQAIILKGYYIPAGTEIATNKCAAHLHQPSWQDPDRFYPPRFLNQETYHETRRNMLSFAYGTRFCIGRNLAWAVMMVTLANLFKDYEVELPEDSRFGPTIVDAAGRPKIMPTKMGVATMPADPERDCRMVLSVRITE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
Cytochrome P450 monooxygenase helB3, Helvolic acid biosynthesis cluster protein B3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: METN_BRUME
Sequence: MQHAAVCSGTSRHRRTTVTIEKPPATSAPIVEMKDVRRMFGETAAINGVSLSVARGEILGIIGRSGAGKSTLIRCVNGLEKPDTGSIHIEGREITSLDEDALRPVRRRIGMVFQHFNLLSAKTAAQNIALPLKIAGMPKAERIKRVAELLELVGLSDKASHYPAQLSGGQKQRVGIARALAAEPAVLLSDEATSALDPETTQSILALLKDINAKLGLTILLITHEMDVIRRIADRVIVLDHGLIAEEGPVWKVFANPQSPVTQSMLQVLTPELPAIWRNRLEKKGDQAILRVKLSGMAAKGAFFNDVAAATSLAPQLIHGGMDTIQGEPVGTLFIGLPAEDKTKLKAAIGYLNTHADATEVLGYVSGNA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y6008_DICDI
Sequence: MDKYKSINEKLDIKIEEDEENDIGFKEERYNSQQEDEQLKKDLTICERFGVDSCLISRIIIFVVIFSWIIFIFYISLFE
What are the official names of this protein?
Putative uncharacterized protein DDB_G0284425.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: PYNR_ASPNC
Sequence: MAKKAELRRSCTFCRTRKIACSGERICNACRSRSIECVYDLEIAKGRPRLNKTTSTRASISAGPAGPSPITLEDGEPGDGGHSITSAVNPSITPLTGVMAELEVMFRENFGEDPMAAPSNQFQDRVARFNRNLAAGRASQGPSTPAGSLTYPGFLALLMQDLAETVTGKFGDLGCHPFFGPGERFYRACMLQDTTKTMFDTACLPSPSTSTPSGGEADILADYNSHLITQHLEVWMSNHPLSIIISKSLLLRDLRSQTANRVLLAVMLADAHHFADNSAKGDRLLQWAVSQLSNIPAGQEDLTTAQITLLLGWFHVCRGHSRRALCYVGYAGRITTKLASQLHESPLTGQTHINGIDRGAVEAEMIHHMYWVMLALTVWSFIQMDMPLADLLPAQLLQVLPARTTPDSTLLQLDRATDNLSTLKPQLSSLQSVWLLSHVTVLSAHLYALYPQHLRSPPEPQPWQDLMLHRLNRLLRQGRSLTQICSDSRNALLDIIVVLQKESAHGRGEPTLLALYLAVSIHLLFPRDETGHHVHNSQTFVLSDTLFQQLIASIQDLKQLFPAISSVARHDSSQPASTGSAGLHFYLLALDALGRALMYVLTVWDRVTAVEQRVWQDRLRGLLDGGLAMHDLFEYDALLQDHRWRSVKKHLKTACKGIKGVLSGSRDQGSRSSSSSVSSLDLSFALPSRPTPAMGIPTSEEGRSEMMFPTMPSASGIPSSISSSISHTSREVGLSWPGDGQILPTQEQGPRESSHPAASDLSDFDLAPFVSLGSIDSMQNGDERSRIMQQFSPNPMSLPSFWHDPQFSPAHHLVGTMPPPSLISLADLGMGERGQKRSSEKLGGLSEGDTPGTSADGGTKRRMKGMSN
What is the function of this protein?
Transcription factor that regulates th eexpression of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds.
What are the official names of this protein?
Transcription factor pynR, Pyranonigrins biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIM_DESHD
Sequence: MKEKLTKALQALKHKTPLVHAITNVVTVNDCANSLLAVGASPAMCEAADEVFEFSQLAGSLYLNLGTLTKEQEMAAYLAIRGATLKGIPVILDPVACGAIPRKKATIERLGHFGRFTVIKGNLGEVKALAGLAARVRGVDSLDEGNDGLEACQSLARAYGCVVAATGKVDIVADGQRACLIENGTEMLTRITGAGCMAGALVAGFCGAYEDAFGATVAALLTMSLAGELAQETSGGELPGTFRAHLIDQLSLVDEALIEKRGRVQWL
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PSBL_SYNJA
Sequence: MADQPEKNPNTQPVELNRTSLYLGLLLVFVVGLLFSSYFLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RSMH_CHRVO
Sequence: MSTPTFVHRTVLLTEAVDALAIRPDGVYVDCTFGRGGHSRLILSKLGPSGRLIAFDKDPEAIAVADRLAAEDSRFNIVHNGFETLSAELARLGVAGVDGVLMDLGVSSPQIDDGSRGFSFRFDAPLDMRMDTTRGVTAAEWLATADEADIREVIKTYGEERFARKIAAAIVAQRDESPITTTRELAVLVGQNVRTREPGQDPATRTFQAIRIFVNRELDELKAVLPQAARLLNEGGRLAVISFHSLEDRIVKLYLRDVSSEEKLPAWAMVRAADMAQPPIDLVGKAIRAGDEEVRENPRARSAIMRVAQRTAAPWREGDA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_CHICK
Sequence: MAPRKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TARI_STRA3
Sequence: MNIGVIFAGGVGRRMNTKGKPKQFLEVHGKPIIVHTIDIFQNTEAIDAVVVVCVSDWLDYMNNLVERFNLTKVKAVVAGGETGQMSIFKGLEAAEQLATDDAVVLIHDGVRPLINEEVINANIKSVKETGSAVTSVRAKETVVLVNDSSKISEVVDRTRSFIAKAPQSFYLSDILSVERDAISKGITDAIDSSTLMGMYNRELTIVEGPYENIKITTPDDFYMFKALYDARENEQIYGM
What is the function of this protein?
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
What are the official names of this protein?
Ribitol-5-phosphate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.
Protein: YCIB_HYDCU
Sequence: MKLLFDLFPVILFFIAFKLYGIYVATAVAIIASIAQVAYVYAKNKRIEKMHIITLALIVILGGATLILQDETFIKWKPTVVNWGFALVFLGSHFIGQKPIIRRMMDQAISLPDTAWIKLSYMWIAFFIFSGIANIYVAYQYDTDTWVNFKLFGLMGLTLAFILIQGVYISRFIKSSDLDKNDETEEKVMDSTIETLAEVELDSVVDSKHDSKKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS4_RENSM
Sequence: MTEMILELLPAVDVADGQAVRLVQGEAGSETSYGAPIDAALAWQQDGAEWVHLVDLDAAFDRGSNLALLRDVVAQLNVKVELSGGIRDDASLEGALKLGAERVNLGTAALEDPVWTARAIERFGDKIAVGLDVRGTTLAARGWTKDGGDLWEVLARLEDAGCARYVVTDVTKDGTLRGPNIELLQQMLERTDRPVVASGGVSSLDDLVQLRALVPHGLEGAIVGKALYAGAFTLPEALDVAGRR
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIWAZ_DROME
Sequence: MQVRTPFVALDQRSPLTVDSSCPKRKKCDMDRERERDVKALEPRDLSSTGRIYARSDIKISSSPTVSPTISNSSSPTPTPPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGNHKPITGIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFTIEASVGGQQFSEYLLARRVPM
What is the function of this protein?
Functions with the transcription factor TfAP-2 to regulate octopamine neuronal signaling pathways that control behaviors such as male aggression, male mating, and the initiation of feeding (PubMed:30231996, PubMed:24142897, PubMed:25187989).  Required for TfAP-2 transcriptional activity in octopaminergic neurons (PubMed:24142897, PubMed:25187989).  Functions with TfAP-2 to regulate expression of genes which are involved in promoting octopamine production and secretion from octopaminergic neurons, such as Tbh and Vmat (PubMed:24142897, PubMed:25187989).  Octopamine then modulates feeding and male aggression by regulating the expression of the satiation hormone Dsk in insulin-producing cells (IPCs) (PubMed:24142897, PubMed:25187989).  Functions with octopamine and Dsk as part of a negative feedback loop to prevent overeating; acts with TfAP-2 to regulate octopamine signaling pathways that initiate feeding, then octopamine activates expression of Dsk which inhibits consummatory behavior (PubMed:25187989).  May also be involved in negatively regulating nociception in larvae to prevent spontaneous pain and hyperalgesia (PubMed:30231996).
What are the official names of this protein?
BTB/POZ domain-containing protein Tiwaz, Potassium channel tetramerization domain-containing protein Tiwaz.
Protein: FENR_RICTY
Sequence: MYNTDIVIIGSGPVGLFAVFQAGMLGMKCHVIDAQEVIGGQCITLYPEKHIYDIPAYPKITAKELIEQLKSQAAPFNPVYHLNQQAIELNKHNDFFEIKTSKNTIIKSKVIIIAAGAGAFGPNKPPLANIEDFEGKSIFYFINDKSKFLGKNIVVAGGGDSAVDWTIALSEIANKIYLVHRRDKFTAATESIRQLRHIAETGKIELVTGYQLNNLDGHNNELQAVIVKDLQNNIRKLDANILLPFFGLKQDLGPLANWGLNVKLQHIEVDNYYYQTNIKGIYAIGDVAHYVGKLKLIITGFAEAAHSINHAYSRVFDGKALHFEYSTNKYEQKQ
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SYFA_UREPA
Sequence: MDVINLIKNLKQILRTANNERHLIELKNIFVKQHLLPLYDELKKSANKKEMGLLINNFKQQIEFVTDQILKELNDKDDQVDLKKWTNKTLFAPFINNGHHHILNSIIDDIASFFKKLNFEIVSGSEVVSPIYNFDHLNIDENHPARASADSFFINSIKMLRTHCTTTTAQFLENNVNKDIRIMSFGNVYRKDDDDATHSHQFNQVDFVWVKEGLTVANLKWLIDSLIKYLFGQNLKTRYRLSFFPFTEPSFEVDVQCFKCDLKGCAVCKKSTWIEIMGTGMLHENVLKAANINDIRTGMAFGVGIDRIAMLKYEIDDIRYLYSNNFKFNAQIK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXUR_BACSU
Sequence: MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLNYTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDDLKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDKEGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQYDMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGFSQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT
What is the function of this protein?
Transcriptional repressor for the exu locus which is required for galacturonate utilization.
What are the official names of this protein?
Probable HTH-type transcriptional repressor ExuR, Probable galacturonate locus repressor.