PharMolix/UniProtQA huggingface dataset:
Protein: SLMA_ECODH
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLLLGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDETLLASQILAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NEP_I54A0
Sequence: MDPNTVSSFQDILLRMSKMQLESSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNEKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALHLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RUVB_STAA2
Sequence: MNERMVDQSMHSEETDFELSLRPTRLRQYIGQNSIKSNLEVFIKAAKLRHEPLDHVLLFGPPGLGKTTLSNIIANEMEVNIRTVSGPSLERPGDLAAILSGLQPGDVLFIDEIHRLSSVVEEVLYPAMEDFFLDIIIGKGDEARSIRIDLPPFTLVGATTRAGSLTGPLRDRFGVHLRLEYYNESDLKEIIIRTAEVLGTGIDEESAIELAKRSRGTPRVANRLLKRVRDFQQVNEDEQIYIETTKHALGLLQVDQHGLDYIDHKMMNCIIKQYNGGPVGLDTIAVTIGEERITIEDVYEPFLIQKGFLERTPRGRKATPLAYEHFAKSNEERG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: KLH22_AILME
Sequence: MAEEQEFTQLCKLPVQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYTLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVANALMYHRNESLQPSLQGPHTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGRYIYAVAGRDYHNDLNAVERYDPTTNSWAYVAPLKREVYAHAGATLEGKMYVTCGRRGEDYLKETHCYDPDSNTWHSLADGPVRRAWHGMATLLDKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDTRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRTLLLEPPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores.  The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.  Monoubiquitination of PLK1 does not lead to PLK1 degradation.  The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5.  Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway.  It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
What are the official names of this protein?
Kelch-like protein 22.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Lysosome. Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. Localizes to the nucleus upon amino acid starvation. Relocalizes to the cytosol and associates with lysosomes when amino acids are available.
Protein: OSKA_DROME
Sequence: MAAVTSEFPSKPISYTSTNTSAKTYYLKSVKKRVTTCFQQLRDKLQSSGSFRKSSSSCLNQIFVRSDFSACGERFRKIFKSARKTELPELWKVPLVAHELTSRQSSQQLQVVARLFSSTQISTKEITYNSNSNTSENNMTIIESNYISVREEYPDIDSEVRAILLSHAQNGITISSIKSEYRKLTGNPFPLHDNVTDFLLTIPNVTAECSESGKRIFNLKASLKNGHLLDMVLNQKERTSDYSSGAPSLENIPRAPPRYWKNPFKRRALSQLNTSPRTVPKITDEKTKDIATRPVSLHQMANEAAESNWCYQDNWKHLNNFYQQASVNAPKMPVPINIYSPDAPEEPINLAPPGHQPSCRTQSQKTEPTENRHLGIFVHPFNGMNIMKRRHEMTPTPTILTSGTYNDSLLTINSDYDAYLLDFPLMGDDFMLYLARMELKCRFRRHERVLQSGLCVSGLTINGARNRLKRVQLPEGTQIIVNIGSVDIMRGKPLVQIEHDFRLLIKEMHNMRLVPILTNLAPLGNYCHDKVLCDKIYRFNKFIRSECCHLKVIDIHSCLINERGVVRFDCFQASPRQVTGSKEPYLFWNKIGRQRVLQVIETSLEY
What is the function of this protein?
Organizes the germ plasm and directs localization of the posterior determinant nanos.  Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.
What are the official names of this protein?
Maternal effect protein oskar.
Protein: NAA11_MOUSE
Sequence: MNIRNARPDDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFGAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLSQMTDELRRQLVLKKNRYVVLGSEETQGGTLPDAGEACLPKNPTSKDSGSSDSTDVQDSSEDLDSIS
What is the function of this protein?
Displays alpha (N-terminal) acetyltransferase activity.  Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.
What are the official names of this protein?
N-alpha-acetyltransferase 11, N-terminal acetyltransferase complex ARD1 subunit homolog B, NatA catalytic subunit Naa11.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ARD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: P2C36_ARATH
Sequence: MGNGVASFSGCCAGTTAGEISGRYVTGVGLVQENLGHSFCYVRPVLTGSKSSFPPEPPLRPDPIPGTTTTFRSISGASVSANTSTALSTSLSTDTSGIASAFESSNRFASLPLQPVPRSPIKKSDHGSGLFERRFLSGPIESGLVSGKKTKEKAKLKKSGSKSFTKPKLKKSESKIFTFKNVFTNLSCSKKSVIKPINGFDSFDGSSDTDRYIPEINSLSTIVSSHEKPRIKEEEDKTESALEEPKIQWAQGKAGEDRVHVILSEENGWLFVGIYDGFSGPDPPDYLIKNLYTAVLRELKGLLWIDKGESYNRNGESNIEKQSTVEHASDSDQENCPVMNGNDVACGSRNITSDVKKLQWRCEWEHNSSNKSNNINHKDVLRALQQALEKTEESFDLMVNENPELALMGSCVLVTLMKGEDVYVMSVGDSRAVLARRPNVEKMKMQKELERVKEESPLETLFITERGLSLLVPVQLNKEHSTSVEEEVRRIKKEHPDDILAIENNRVKGYLKVTRAFGAGFLKQPKWNEALLEMFRIDYVGTSPYITCSPSLHHHRLSSRDKFLILSSDGLYEYFSNEEAIFEVDSFISAFPEGDPAQHLIQEVLLRAAKKYGMDFHELLEIPQGDRRRYHDDVSVIVISLEGRIWRSSM
What are the official names of this protein?
Probable protein phosphatase 2C 36, AtPP2C36, Protein POLTERGEIST-LIKE 3, Protein phosphatase 2C PLL3, PP2C PLL3.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPF_XANOR
Sequence: MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMVDVVALFRNNSKEEVREVVRTVRPTLLQFHGEEEDAFCRSFNLPYLKAVPMGSTGVNGEDANARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTGLHRPFLLAGGINAGNVFDAIVATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHEMS
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: NUOK_MYCTA
Sequence: MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAFVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBF_NAREL
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GLGA_GEODF
Sequence: MKILFVASEVTPFAKSGGLADVTGALPKSLKKQGHDVRIILPFYSEVERGGYGIRKGRKSVDVMIGGSVKRGLFRHTNLEDIPVYLLENKEYFSRDHLYGTASGEYPDNHLRFAFFCRGVLDLLKKMDYRPDIIHCHDWQTAMIPLILKKEKGDDLFFSKTGTVFTIHNLAYQGLFPKEAMVDMGLDPSLFTIDCLEYYGKVNLIKGAILTADVINTVSETYCREILTPESGDGLDGVLTLRKNDLYGVLNGIDYEHWNPATDRGISKNFTPGAPAGKAANKKALQKRLGLEIAEDIPLVGMVSRLTEQKGLDLLEALLPRIAKAKLQLVLLGTGDEKYLKLLQEFAALGTDNVSVNIGFHPELAPQIYAGSDIFLMPSRYEPCGLGQMIALRYGAVPVVRKTGGLADTIFDERDQPKEPNGFSFDEYTPEALWEALSRAVEAYSDKAAWKKMMKRGMAGDFSWNTSALKYEELYRLVLAKKGR
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: GATB_CHLL3
Sequence: MKYELVVGLEVHCQLNTASKAFCSCSAQFGKPANSNVCPVCLALPGALPVLNRRVVEDAVKLGLATGCAIAPHSVLARKNYFYPDLPKGYQISQFEEPICIEGHLMVDAGEGEKLIRLIRIHIEEDAGKSIHDIGDDTYIDVNRCGVPLLEIVSYPDIRTAKEASTYLQKLRQIVKYLGISDGNMEEGSLRCDANVSLRPVGDEEYGTRTEIKNMNSFKNVEKAIEFEAERHRGILEEGGTIVQETRLWDADKGETRSMRGKEFAHDYRYFPDPDLVPVLVDDEMLRRIRLELPEFPEARASRFVEQYGIPVYDAAVLTVEREMADYFEAVVEVAGDGKVSSNWVMGEVMRTLKEKYLDITAFSVAPSRLGGLIKLIGSGAISNTIAKQVFELMQQSEASAEEIVQREGLAQVSDTGEIERVVDEILAANPDQLAGYREGKVKLFGFFVGQCMARMKGKANPKVVNEVLQRKLEG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: TGT_NAUPA
Sequence: MEFRIDSIDGNARACTIKTEHSEIKTPIFMPVGTAAAVKSLDAIDMMEILDAPIILGNTYHLYLRPGDEIISKLGGLHGFSGYKRSFLTDSGGFQAFSLGDNVKFTDEGIWFKSHIDGSKHFFSPEKVIDIEYNLNSDIMMVLDDLIALPNTKERIKKSIERTTEWAYRSLVHHVNRGKKNNLFAIIQGGTDFEFRRISAESLVSLEYKGYTFDGFAIGGLSVGEENQLMYDTIEATTPYMPKDKPRYLMGVGTPEDIIEAVERGVDMFDCVMPTRNARNGYLFTTFGTLRIKNAKYKLDESPIDPKCNCYTCRNFSRAYLNHLFKAKELTYFRLASIHNLHYYLNFVKEIREAILEGRFKEYKKEFYSLRAMNSLEI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: BASS4_ORYSJ
Sequence: MVTTHHLCLLRSTVLSVPVRLRAPRAPPHPRLPTASASASSYHGPTHLRRLRPLRAAAAAAGGASPDGADGAKRPAPAAASSSLGAALVGFARSNFLPLALIAGIALALMDPTLGCLAHKYSLSKYSTFGIFLISGLTLRTKELGAALEAWPAGLFGLASILLFTPFLAQFIMQIKFFPHEFITGLAMFCCMPTTLSSGVTLTQLVGGNTALALAMTAISNLLGIMIVPLSLAKYIGVGAGVSLPTEKLFKSLVTTLLIPIILGKVARETSKGIAGFVDGNKQGFSVTSAILLSLVPWIQVSRSRSLLLSVQPKAFAVAVTVGVLLHFALLAFNAAALHILSRLEQRGVSVFARNEYARAVILVASQKTLPVLVAVVEQLGGALGESGLLVIPCVAAHINQIIIDSIIVNWWRQRDQQFANAK
What is the function of this protein?
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
What are the official names of this protein?
Probable sodium/metabolite cotransporter BASS4, chloroplastic, Bile acid-sodium symporter family protein 4.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Protein: VF175_ASFB7
Sequence: METNCPNILYLSGITIEECLQTKKTATDTLNTNDDEAEVEKKLPSVFTTVSKWVTHSSFKCWTCHLYFKTVPKFVPTYMRENERGEIEMGVLGNFCSFSCAASYVDVHYTEPKRWEARELLNMLYRFFTSQWISYIKPAPSYTMRKEYGGKLSEEAFISELHTLEESISSKHIFI
What are the official names of this protein?
Uncharacterized protein B175L, pB175L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B175L family.
Protein: ISPE_PORG3
Sequence: MIVFPNAKINLGLQVVAKRADGYHNIETVFYPIPLTDALEIEVREDTCDRLSVHGIPIDAATEDNLVMKAILALRRKFDFPPLTIELIKHIPSGAGLGGGSSNASFMLKLVRDYFSLPIDDKELAAIALTIGADCPFFVGNRPVLATDLGQVFTPLPNFSLSGLHIAIVKPPIHINTAAAYKGLKHVGKRETMPDEIVYMPVDEWRGKLVNDFEESLFPEHPRLAELKEMLYRSGALYAAMSGSGSALFGLFREKPQLDKAAITDCFRWQSIIP
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PFR2_TRYBB
Sequence: MAAVDDATGLEAARKQKIHNLKLKTACLENEELVQELHVSDWSETQRQKLRGAHLKAEELVAAVDVGTKWNLTEVYDLAKLMRVCGLEMSQRELYRPEDKAQFMDIIAMKKVLQDLRQNRNKTRVVSFTQMIDNAIAKVEKVEEDVRRSQLDATQLAQVPTQTLKQVEDIMNVTQIQNALASTDDQIKTQLAHVEKTNEIQNVAMHDGEMQVAEEQMWTKVQLQERLIDLIQDKFRLISKCEEENQAFSKIHEVQKQANQETSQMKDAKRRLKQRCETDLKHIHDAIQKADLEDAEATKRHAANKEKSDRYIRENEDRQEETWNKIQDLERQLQKLGTERFDEVKRRIEEIDREEKRRVEYSQFLEVASQHKKLLELTVYNCDLAIRCTGLVEELVSEGCAAVKARHDKTSQDLAALRLDVHKEHLEYFRMLYLTLGSLIYKKEKRMEEIDRNIRTTHIQLEFCVETFDPNAKKHADMKKELYRLRQGVEEELAMLKEKQAKALEEFKESEEVSGRCWHRVQPPCDENNEEVLTRRSKMVEYRSHLTKQEEVKIAAEREEIKRALTAQLWCRWRAGPHRKQHCTHASNSVAAIIM
What is the function of this protein?
Major component of the paraflagellar rod (PFR).  The PFR is a highly ordered lattices of fibrous proteins that are located inside the flagellum and assume a fixed orientation with respect to the microtubular axoneme.
What are the official names of this protein?
73 kDa paraflagellar rod protein, 73 kDa PFR protein, PFR-C/PFR-D.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton.
Protein: RL15_SYNY3
Sequence: MNLSELSPKDGAKKRRRRVGRGIAAGQGASCGFGMRGQKSRSGTGTKAGFEGGQMPLYRRLPKLKHFPLYNPKHFTVVNVGKLAGLAPNTVVTLESLMEAGIVTSNDGPLKVLGNGELAVALTVHAPCSKAAQAKIEAAGGSVVAQG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SRP19_CAEEL
Sequence: MTSVASEPLSSQKRWIVIYPAYIDKKKTAKQGRKISQILAVENPTSVEIHDVLAAVGFNPLLERTKCYPRDGERDFEVQGRVRVQLKNDDGTAKHEQKTRDEIFKMVAEMIPKLKTRQPGYTAPSVASSSAAAAGKKNKKKK
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  Binds directly to 7SL RNA (By similarity).  Mediates binding of SRP54 to the SRP complex (By similarity).
What are the official names of this protein?
Probable signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: IL2_MUSSP
Sequence: MYSMQLASCVTLTLVLLVNSAPTSSPTSSSTSSSTAEAQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLQSVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTIECQFDDESATVVDFLRRWIAFCQSIISTSPQ
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PLSX_ACISJ
Sequence: MITLAVDCMGGDHGPGVTLPACRQFLEHHPDARLILVGGQDSLQGLVHERVTHVVASEVVTMDDAVEVALRRKKDSSMRVAIQQVKDGVAHAAISAGNTGALMAIARYLLKTLDGIDRPAIATQMPNAQGGATTVLDLGANVDCTAEHLLQFAVMGSALVSVLQDRDEPLVGLLNIGEEVIKGNDVIKKAGGLLRSAAKSGDLNFHGNVEGNDIFKGTVDIVVCDGFVGNVALKASEGVASMIAGALKQEFSRNIFTKIAAIVAYPVLSAIMKRMDHRRYNGAALLGLRGLVFKSHGSADALAFEQALIRAYDAARNNLLDRVRARVAHAAPLLAAADAQPAS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RPOA_YERPN
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASINMRIKVQRGRGYVPASARIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RBFA_CORA7
Sequence: MVDHARAARMAKRIQTIVASAIERQIKDRRLELVTITDARVTGDLHDATVFYTVRGTDIGTEPDYDQAAEALTRAKGQLRKIVGDELSVRFTPTLSFELDTVPEASAHMEELLARARARDAELAKLKEGAQPAGDANPYKTSDEEED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.