PharMolix/UniProtQA huggingface dataset:
Protein: GHRA_ECO27
Sequence: MDIIFYHPTFDTQWWIEALHKAIPQARVRAWKSGDNESADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLKPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVDYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_SHEON
Sequence: MTVTSPIVDRYAVFGHPIGHSKSPFIHGQFAALTQESLTYEAILAPIDGFEASLKSFFSSGGKGANVTVPFKEQAFALCDSLSAEAALAGAVNTLSLLADGSIRGDNTDGLGLVADLISHLGSLQHKRVLLVGAGGAARGCILPLLNAGVGQLVITNRTQTKAKDLVDIFSQLEEGIYKDKLQALSMSELTGEFELVINSTSASLAGELPPLPQSIIGSTTVCYDMMYGAMPTAFNQWALQQGAAKVIDGLGMLVGQAAKSFALWRTVEPDTAVVLKLLREKLQLDI
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: PLPL_ASPNC
Sequence: MNGAEKSAAGDTYDPSTIPDYDREFIHPDDLRQFELALTDQGASPLVALNDWRPIYQRVRRERGRRKEPRRTKDETREGVLYTVLKWPFLFTVFGWITALAFAYTLTRVYIFLYEQWVTWRGRRQSLRRQLHAQTNYPDWQKAARALDDHLGNQRWKEIDEYAYYDHLTISNLVKQLKKVRREVERERREKRRGSGQSPAAEELCTLLEACVKNNFAGVENPRLYSEAYSGTKNLVQEYIDELHACIQLVADSKGITSEEKLQHFKHLDTNFGRTALCLSGGATFAYYHFGVVRALLDNGVLPEIITGTSGGALVAALVATRTDEELKQLLVPALAHRIRACQESFPTWVWRWWRTGARFDTLDWARQCSWFCRGSTTFREAYERTGRILNVSCVPSDPHSPTILANYLTSPNCVIWSAVLASAAVPGILNPVVLMTKKRDGTLAPYSFGHKWKDGSLRTDIPIKALNLHFNVNFTIVSQVNPHINLFFFSSRGTVGRPVTHRKGRGWRGGFLGSAIEQYIKLDMNKWLRVLRHLELLPRPMGQDWSEIWLQKFSGTVTIWPKTIPSDFYHILSDPNPERLARMLRVGQQSAFPKLQFIKNRLKIEIAVVKSLQKFAHAGGRPISPAPSRWRQNNDPDNHYNPSPRTDPLNERLDHNLPERRGDNVNITFGEGGGREDTHLLDGSLSENSSNESAARPSSSSSSSRLLRVPEHRRGSTGSSIFEEVRRQSAVFFDDVDMYGDDEALRPG
What is the function of this protein?
Probable lipid hydrolase.
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein An01g04180.
What is the protein family that this protein belongs to?
Belongs to the PLPL family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACP_CUPPJ
Sequence: MDNIEQRVKKIVAEQLGVAEADIKNESSFVNDLGADSLDTVELVMALEDEFGMEIPDEEAEKITTVQQAIDYATAHVKA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEH1_YEAST
Sequence: MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQELRDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHSVPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPLTVPF
What is the function of this protein?
Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272).  Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961).
What are the official names of this protein?
Protein MEH1, EGO complex subunit 1, GSE complex subunit 2.
What are the subcellular locations of this protein?
Vacuole membrane.
Protein: RDRP_I73A4
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTEIGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMASLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNDLTSNESGRLMDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNRKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARRICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSLAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTKKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQRKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKTGLLVSDGGPNLYNIRNLHIPEVCLKWRLMDEDYKGRLCNPLNPFVSHKEIESVNSAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: DPO3_LISMO
Sequence: MTAKEEEKQERFQLLMTQIGLQDVTTYEEFTKDAKIEKLVADKKNKTWQFHLHVPQIFPAALFHMMDVGMKRAFSQIAETEMQIVPENQTINETLIQDYWNLIVEPIGKQSPMIGKLLMEQKPTFKEPHFIEVAVHNDMEEATIQQRFQTKIIESYGKAGFPRLAMKMHMLDQSETDEYKAFAQAKQEEDQKKAAEAVQVMQKRQAEGQSGGGGAAPLTGPFQIGYKIKDDEEVKRLGDIYDEERRITVQGLIFATEIRELRSGRSLLQFKITDYTSSMIIKMFSRDNEDAAMFQNLKKGMWVKVRGSVQNDTFVRDLIMMAQDVNEIAGVKRLDTAEEKRAELHLHSPMSQMDATSSVDSLFKQAADWGHKAIAITDHSVAQSFPEAYGAGQKYGLKVIFGIEANLIDDGVPIAYNDQHIALEDATYCVFDVETTGLSAVYDTIIELAGVKMKNGEIIDKFEAFIDPGHPLSATTINLTGITDDMVKGSDPIDVVLKRFKEWSGDDILVAHNASFDMGFINTAYEKVGLEKAENAVVDTLELARFLYPHFKNHRLNTLTKKFNIILEQHHRAVFDAEATAYLAWKLIKDAKEMHNIDFHDSLNDYMGEGDAYKRARPFHATIYAQTAVGLKNLFKLITMSNINYFYRVPRIPRSQLKKLREGLIIGTACSQGELFEAMMQKGMQAAEKVAEFYDFIEVQPKPVYAPLIERELVRDEKALEEILKNIVRVGEKTGKPVVATGNVHYKDPVDKIYRKILIHSQGGANPLNRAELPDVHFRTTDEMLKEFAFLGEEKAKEIVVTNANLVVDWMENLKPIKDELYTPKIDGAEDEVRNMSYAMAHQLYGEKLPEIVEARLEKELKSIIGHGFAVIYLISHKLVKKSLVDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYLCPNCKDSEFFDDGSVGSGFDLPDKDCPHCGTAYQKEGQDIPFETFLGFKGDKVPDIDLNFSGDYQPVAHAYTKEIFGEDYVFRAGTIGTVAEKTAFGYVRNYERDMNMTIRGAEIDRLVAGCTGVKRTTGQHPGGIIVIPDYMDVYDFTPVQFPADATDSEWKTTHFDFHSIHDNVLKLDILGHDDPTAIRMLQDLSGIDPKTIPTDDPDVMKLFGSTESLGVKPADIDSKTGTLGIPEFGTRFVRQMLEQTKPTTFSELVQISGLSHGTDVWLGNAEELIKNKTCELPDVIGCRDDIMVFLIYQGLESSLAFKIMESVRKGKGLTDEMEEAMMANKVPLWYIESCKKIKYMFPKAHAAAYVLMAVRIAYFKVHYPLYFYATYFTVRADDFDLTSMVNGKEAVKATMKEVNDKGMEASTKEKNLLTVLEIANEMLARGFHFQKVDLYKSSADEFIIDGESLIPPFNAIPSLGTNVAKQIVAARENGEFLSKEDLQQRGKVSKTIIQYMDDQGCLEGLPDQNQLSLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI4KB_PAPAN
Sequence: MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLRGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGATVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).  May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity).  Involved in Golgi-to-plasma membrane trafficking (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment.
Protein: DCUP_SHIBS
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKVTRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15E_METMJ
Sequence: MAKSMYAYVREAWKRPDRSEVKALLWERLQTWRREGSIVRVEHPTRIDRARSLGYKAKQGIVVVRVKIRRGGRRKPRYTRGRRSARMGMRRLTPAKSLQRMAEERASRKFPNMEALNSYWVGEDGRSKWFEVILVDGHHPSIKSDRNLAWLANPVHRGRAERGKTSAGMKGRGMRTRGRGTEKTRPSIRSHANRGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: RPOC1_PROHO
Sequence: EVTKPETINYRTLKPEMDGLFCERIFGPAKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVTHVWYLKGIPSYISILLDMPLRDVEQIVYFNSYVVLDPGNHPELQTKQLLTEDQSMELEDQIYAEDSTLEGIEVGIGAEALERLLQDLELEQDAERLREEINSAKGQKRAKLIKRLRVVDNFVATGSH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: ECHH_RHIME
Sequence: MSYETLLVETQGRVGLITLNRPQALNALNAVLMRELDAALKAFDADRAVGAIVLAGSEKAFAAGADIKEMQGLDFVDGYLADFLGGWEHVANARKPMIAAVSGFALGGGCELAMMCDFIIASETAKFGQPEITLGVIPGMGGSQRLTRAVGKAKAMDLILTGRMMDAAEAERSGLVSRVVAPDRLLEEALGAAEKIASFSLPAAMMAKEAVNRSLELTLAEGLRFERRLFQSLFATEDQKEGMAAFVAKRKAEFKHR
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: TNFA_CAMBA
Sequence: MSTESMIRDVELAEEALPKKAGGPQGSRRCLCLSLFSFLLVAGATTLFCLLHFGVIGPQKEELLTGLQLMNPLAQTLRSSSQASRDKPVAHVVADPAAQGQLQWEKRFANTLLANGVKLEDNQLVVPTDGLYLIYSQVLFSGQRCPSTPVFLTHTISRLAVSYPNKANLLSAIKSPCQGGTSEEAEAKPWYEPIYLGGVFQLEKDDRLSAEINMPNYLDFAESGQVYFGIIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: CHX10_ARATH
Sequence: MNTTTYIGDCRISFFNISSQGFWDNLKSPDVVFGYSLPLLEIQIILIFFCIVMSHMFLRCIGISQIASYMIAGIVLGPQLFDVLEKSSGKLSVDPALDGIAALRCISVFGTLMFTFLMTVRTSRRVAFHSGKLPVVIGIVSFFAPLFGLGFQNFFSDNIDPHYMPLTKALGERTAIVITQSSILLPSTTYILLELKIINSELGRLALSACVINDILGIFSMIVASIQATYIHVSHATAYRDTVAVIIFFLVVFLVFKPMVQWVIDRTPEDKPVEDMYIHAVIITALASAAYFVFFNMKYILGPLMIGIIIPEGPPLGSALEAKFERLTMNVFLPISITFSAMRCDGARILSQFNDIFFNIFLTFLILVIKLVACLAPCLYYKLPLSESLAVSFILSYKSFADFVLYEAVLDDTYISQATYSFLILYSLLNAGIVPTVLRRMYDPRRKYVNYQKRDILHLERNSDLRILTCLHKPENVSETIAFLQLLSSPNLDFPIAVTVLHLVKLVGQINPIIVSHDKKLKRLNKDSYIHTANLAFRQFVLESLESVTVTTFTAFSHENLMHEDICTLALDKTTSMIVVPSGRKWTVDGLFESDNTAIRHLNQSLLDRAPCSIGILVDRGQFSRKSIVTSKKRYIIDVGVLFIGGKDDREALSLVKRMKNNPRIRVTVIRLVFDHEIESDWDYILDNEGLKDLKSTEDNKDIDYIERIVTSSVEVVKAVQLLAEEYDLMVVGRDHDMTSQDLSGLMEWVELPELGVIGDLLAARDLSSKVSVLVVQQQQQRT
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 10, Protein CATION/H+ EXCHANGER 10, AtCHX10.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SUCC_MARMM
Sequence: MNIHEHQAKAVLKSFGAPVAEGVAIFSADEAAAAADQLPGPLWVVKSQIHAGGRGKGKFKELGSDAKGGVRLAFSKEDVVKNAKEMLGNTLVTHQTGPEGKRVNRLYIEDGADIATELYCSLLVNRETGQVAFVVSTEGGMDIEEVAAETPEKIQTIDIDPSTGVTDASAAAVCDALKLEGQAREDMMGLAKILYTAFCEKDMSMLEINPLIVMDNGHVRVLDAKVSFDGNALFRHPDIMELRDTTEEDEKEIEASKYDLAYVALDGDIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGATTEKVTAAFKIITADPNVKGILVNIFGGIMRCDVIAEGVVTAVKDVGLQVPLVVRLEGTNVAKGKQIINESGLNVIAADDLDDAAQKIVAAVKEAN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PHZC_PSEFL
Sequence: MEDLLKRVLKCEALQQPQWSEPSQLHDAQAYLRDSASLIRVEDILVLRATLARVAAGEAMIIQCGDCAEDMDESAADHVTRKAALLDMLAGTFRLVTQQPVVRVGRIAGQFAKPRSNHSERIGDVELPVYRGDMVNGRDAVLGHRQHDAQRLVRGYRAAQDIMQHLGWKEPSGQEQLTGSPAWTSHEMLVLDYELPQVRRDEQGRTFLGSTHWPWIGERTRQLTGAHVALLSEVLNPVACKVGPDITQDQLLSLCERLDPRREPGRLTLIARMGAHKVADRLPPLVEAVRRAGHKIIWLSDPMHGNTIVAPCGNKTRMVQTITDEITAFKHAVVSAGGVAGGLHLETTPDDVSECASDAAGLGQVGSHYKSLCDPRLNPWQAITAVMAWKACPPPSFVSL
What are the official names of this protein?
Probable phospho-2-dehydro-3-deoxyheptonate aldolase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-II DAHP synthase family.
Protein: MSCL_ECO57
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FER3_DESAF
Sequence: GYKITIDTDKCTGDGECVDVCPVEVYELQDGKAVAVNEDECLGCESCVEVCEQDALTVEEN
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin-3, Ferredoxin III.
Protein: RL17_SPHAL
Sequence: MRHKSGGRKLQRTSAHRTAMFRNMSASLIKHEQITTTVAKAKELRPYVEKLVTLAKRGGLANRRLAMSRLMDEAQLAKLFDVLAARYKDRNGGYTRIIKAGIRASDAAPIAIIEFVDRDMGAKGQDSGPVTTDEELEDA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: MLN_HUMAN
Sequence: MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS
What is the function of this protein?
Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity.  Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.
What are the official names of this protein?
Myoregulin.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MT2_YARLI
Sequence: MEFTSALFGASLVQSKHKTTKKHNLVDSCCCSKPTEKPTNSCTCSKCACDSCKC
What are the official names of this protein?
Metallothionein-2, MT-2, Metallothionein-II, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 11 family.
Protein: TUB11_BPPH2
Sequence: MSSYTMQLRTYIEMWSQGETGLSTAEKIEKGRPKLFDFNYPIFDESYRTIFETHFIRNFYMREIGFETEGLFKFHLETWLMINMPYFNKLFESELIKYDPLENTRVGVKSNTKNDTDRNDNRDVKQDLTSNGTSSTDAKQNDTSKTTGNEKSSGSGSITDDNFKRDLNADTADDRLQLTTKDGEGVLEYASQIEEHNENKKRDTKTSNTTDTTSNTTGTSTLDSDSKTSNKANTTSNDKLNSQINSVEDYIEDRVGKIGTQSYARLVMDYREALLRIEQRIFNEMQELFMLVY
What is the function of this protein?
Forms the proximal part of the tail tube.
What are the official names of this protein?
Proximal tail tube connector protein, Gene product 11, gp11, Lower collar protein, Protein p11.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus proximal tail tube connector protein family.
What are the subcellular locations of this protein?
Virion. Note=Present in 12 copies in the virion (Probable).
Protein: HIS8_GEOKA
Sequence: MQVKESLRGLSPYQPGKSIEEVKRQYGLPEIIKLASNENPYGSSPSAKAAIAAELDRLAVYPDGCARTLREKVAKHLGVKETQLLFGNGSDEVVQILCRAFLEPGANTVMAAPTFPQYRHNAIIERAEVREVPLVDGRHDLEAMLAVIDENTRIVWICNPNNPTGTYVNDTELRAFLDRVPRHVLVVVDEAYYEYATAPDYPQTVPLLNEYEQLVVMRTFSKAYGLAALRVGYGVASEMLIRAVEPAREPFNTSTIAQAAAAAALDDQAFIRACVERNRAELERYYRFCEENGLKYYPSQTNFLFIDFGLDGDEVFRYLLERGVIVRSGQALGLPTGVRVTVGTKEQNDRVLELVSQLLREKQLA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RSGA_CYTH3
Sequence: MKGIIYKSTGSWYLVKAEDGTYYNARLRGKFKHLDLKVTNPLSVGDFVDMNIDPLTPTEAMIFNIEPRTNYIIRRSSHKTAFGHLIACNIDQSILLVTLKQPKTSIGFIDRFLISCEAFRIPAVIVFNKSDLYNEALMEEYLYLKDVYEPLGYRCILTSMEKENGLDELMPLLQNKISVVSGHSGVGKSTLINKIFPQLDIKTDIISDHSQKGKHTTTFAEMYDLNETSKVIDTPGIKELGLFEIENDVLSHYFPEMRSLMGQCRFHNCKHTNEPGCRVKEYVEAFKIAPTRYESYCSIIFEKDTHR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1023_METJA
Sequence: MKPKIKVENLTKYFGDKKVLDEISFEVYEGEIFGLLGHNGAGKTTTLRILAGIIEEYTGYVEVNGKIGYLPEERGLYRDEKVVDVLKFFGELAGMKKEEIAKSIDYWLNKLKISNYKYSKIKELSKGNQQKVQFIVSVIHNPDIVILDEPFSGLDVVNVRLLRDIIFELKEEGKTIILSTHQLEKIERLCDRVLILKKGKAVHYGKIEDICRKMAYIEYLDNGKLIKKEIPYEEAVLILKEKAEDVIKFEVRYSLEDLFLDE
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein MJ1023.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: YTDC1_MOUSE
Sequence: MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSERMESTDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKTCLRKRDSERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEDYGSDHETGSSGSSEQGNNTENEEEGGEEDVEEDEEVDEDAEDDEEVDEDAEEEEEEDEEEEEDEDEDEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYVKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR
What is the function of this protein?
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:29262316, PubMed:29799838).  M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:29799838).  Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity).  Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity).  In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity).  May also regulate alternative splice site selection (By similarity).  Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (By similarity).  Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (PubMed:29262316).  Also recognizes and binds m6A on other RNA molecules (By similarity).  Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (By similarity).  Also recognizes and binds m6A-containing single-stranded DNA (By similarity).  Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (PubMed:29799838).
What are the official names of this protein?
YTH domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Localizes to a novel subnuclear structure, the YT bodies.