PharMolix/UniProtQA huggingface dataset:
Protein: COX1_RICCN
Sequence: MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMPGGTFLNHDFQLYNVLITAHAVIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISFWLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAAVDMAIFSLHLTGLSSILGSINLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKPDGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFVGFIVWAHHMFTVGLSYNALIYFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSLGALFTAFAGFYYWFGKISGKQYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMFAALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1, Cytochrome aa3 subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SLB_PHIOL
Sequence: MGRSIFVNLGLLVVAFSLRGSEADCPSGWSSYDKYCYKVFDERKNWDEAESFCMEQKTGSHLASILSSEEGSYVANLAFKRVKHPSMWIGLSNIWNQCSWQWSDGSSLGYEAWVEGPDCVMMRLQPGFIDWYSVECKSTLPFTCKFLAKREDPAPE
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec subunit B, C-type lectin subunit B.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_CLOBA
Sequence: MAKKVTGMIKLQLQAGKATPAPPVGPALGQHGVNIMGFCKEFNAKTANQAGLIIPVVITVYQDRSFSFILKTPPAAVLIKKELGLESGSGVPNRTKVGSLTKEQVKKIAETKMPDLNAASIETAMKMIEGTARSMGVTIQE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: METE_RHOJR
Sequence: MTFSFTATVLGSPRIGPNRELKKAVESYWAGRLDAEGLDALARDLRRRTWTSLRDAGLDSVPVNTFSYYDHVLDTAAMLGALPDRVAGIESDLDRYFAAARGNDTVAPLEMTRWFDTNYHYLVPEISPTTTFALDPSKVLRELEEARALDIPARPVVVGPVTFLLLSKAVGSDAPLLDRLDELVPLYADLLGRLAGAGADWVQIDEPALVADRNPKEIAAAKRAYDRLSGLELRPAILVASYFGSLGDALPAIASTGVEGIAIDLVAGSDTLATVPDLTRKHVVAGVVDGRNIWRTDLDAALASLGTLLGSTGSLAVSTSCSLLHVPYTLDAETGIDKALRSWLAFGTEKVREVVTLGTALTSGRESVDDEFALARAAASTRNTDRRLHDATVRARLDALTASDPGRSPAAERREAQSALSLPVLPTTTIGSYPQTTQIRVARAARRKGEIDEAEYLKRMRAEVADVVALQEKLDLDVLVHGEPERNDMVQYFAEQLDGFFATDNGWVQSYGSRCVRPPILYGDVRRSNPMTVEWITYAQSLTQRPVKGMLTGPVTILAWSFVRDDQPLADSANQVALAIRDETVDLQGAGIRIVQVDEPALRELLPLRAADQPGYLDWSVGAFRLATSGVSDSTQIHTHLCYSEFGEVIEAIARLDADVTSIEAARSHMEVLDDLSAVGFDLGVGPGVYDIHSPRVPGVEEIAASLREALKAVPVERLWVNPDCGLKTRGPAEVEASLRNLVDAAKLVRAEL
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RL32_CAUVC
Sequence: MAVPKRKTSPSRRNMRRSHHALGANSFIEDKDTGELRRPHHVDLKTGMYNGKQILTPKED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: TYDP2_DANRE
Sequence: MSALGESRTRLCDQFAFVSGSDSAVAQCYLAENEWDMERALNSFFEAHMDSVFDEEAEKTEVTGNKRKDDTAEASGTKKKLKTDNADCIDLTAEEPTCSITVNSKENQAENGTAKSEVEDSKLSIISWNVDGLDTLNLADRARGLCSYLALYTPDVVFLQELIPAYVQYLKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLIAQVTFSGQKLYLMTSHLESCKNQSQERTKQLRVVLQKIKEAPEDAIVIFAGDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTKANSNKTVPYVSRCRFDRIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT
What is the function of this protein?
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate.  Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue.  Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity).  Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin.  Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry.  Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling.
What are the official names of this protein?
Tyrosyl-DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, TRAF and TNF receptor-associated protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.
Protein: VATG1_MOUSE
Sequence: MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSHGSCSSEVEKETREKMTVLQNYFEQNRDEVLDNLLAFVCDIRPEIHENYRING
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit G 1, V-ATPase subunit G 1, V-ATPase 13 kDa subunit 1, Vacuolar proton pump subunit G 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
What are the subcellular locations of this protein?
Apical cell membrane.
Protein: HBA_THUTH
Sequence: TTLSDKDKSTVKALWGKISKSADAIGADALGRMLAVYPQTKTYFSHWPDMSPGSGPVKAHGKKVMGGVALAVTKIDDLTTGLGDLSELHAFKMRVDPSNFKILSHCILVVVAKMFPKEFTPDAHVSLDKFLASVALALAERYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CLF1_MAGO7
Sequence: MEASRGPPRVKNKAAAPVQISAEQLLREATDRQEEALQKPTQRFEDLEELHEYQGRKRKEFESYCQRSGFNLKNWLQYAQWELEQKEYARSRSVFERALNLHANKVTLWIRYVEAELKSRNINFARNLLDRAVTHLPRVDKLWYKYVWVEEMLGNIPGVRQVFERWMEWQPDEAAWSAFIKLEQRYGEYDRAREIFTRFTMVHPEPRNWIKWSKFEEEYGTSDRVREVFERAIEELSKYGDEFVEERLFIAYARYEAKLHDLDRARAIYKFGLENLPRSKAMLLHKEYTTFEKQYGDREGVEDVVLSKRRRHYEDLVRENPKNYDVWFDYARLEEASGDIDRTREVYEKAIAQVPPTQAKRHWRRYIYLWIFFALWEETEAKNPERARQVYDTCLKLIPHRTFTFAKVWMHKAHFEIRQGDLAAARKTLGRAIGMCPKDRLFKGYIEMEQKLYEFGRCRILYEKHIAYNPANCSTWVKWAELERGLDDLDRARAILDMGIAQPVLDMPEVVWKSYIDFEEEEGEYDKTRSLYERLLDKADHPKVWISYAQFEINIPEEAGEGADEEQEQPVSDEAKARARRVFERAHQGFKDKEMKAERVSILNAWLVFEKTHGSAEDIEKIEKQMPRRTKKKRKLDDDTWEEYVDYIFPADEQVGKNLMNMMAKARARKQAEAEAAAKAAAADDGGESGE
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle progression.  Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CLF1.
What is the protein family that this protein belongs to?
Belongs to the crooked-neck family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VIRB_SHISO
Sequence: MVDLCNDLLSIKEGQKKEFTLHSGNKVSFIKAKIPHKRIQDLTFVNQKTNVRDQESLTEESLADIIKTIKLQQFFPVIGREIDGRIEILDGTRRRASAIYAGADLEVLYSKEYISTLDARKLANDIQTAKEHSIRELGIGLNFLKVSGMSYKDIAKKENLSRAKVTRAFQAASVPQEIISLFPIASELNFNDYKILFNYYKGLEKANESLSSTLPILKEEIKDLDTNLPPDIYKKEILNIIKKSKNRKQNPSLKVDSLFISKDKRTYIKRKENKTNRTLIFTLSKINKTVQREIDEAIRDIISRHLSSS
What is the function of this protein?
Transcription activator for the invasion antigens IpaB, IpaC and IpaD.  VirB is itself regulated by VirF.
What are the official names of this protein?
Virulence regulon transcriptional activator VirB, Cell invasion regulator InvE.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: KGUA_HAEDU
Sequence: MLGNLYILSAPSGAGKSSLINALLADLPRTEVQLSISHTTRQPRVGETHGIHYYFTEHHEFESLIEQGHFLEWARVFDHYYGTSLPMIERSLAQGIDVFLDIDWQGARQIREKVPNVKTIFILPPSRAELEKRLVGRGQDSLETIAKRMEQAVSEMTHYNEFDYVIINDQFKTALTELKSILTAERLKQSAQAIRQQALIAELLAE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SYNPW
Sequence: MAPLRILISNDDGVFADGIRALAGAAAAAGHQVTVVCPDRERSATGHGLTLQTPIRAEKADSLFDAGISAWACSGTPADCMKLALFELMDEAPDLVLSGINHGPNLGTDVFCSGTVAAAMEGTLEGLPSMAISSACFQWRDFQGAAALAVEVATAALRDQWPENLLLNLNIPPCRPEVMGPLRWTRLSIRRYDEQFSPRKDPRGRTYYWLAGEVVEDLESGGDGPRDWPTDVAQIEANSPSLTPIQPELFWRGPLGGLPRLELNGQRVR
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_STRT1
Sequence: MGKFQVISHPLIQHKLSILRREDTSTKDFRELVNEIAMLMGYEVSRDLPLEEVEIQTPIIKTVQKQLSGKKLAIVPILRAGIGMVDGFLSLVPAAKVGHIGMYRDEETLEPVEYLVKLPEDIDQRQIFVMDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQDAHPDIDIYTASLDERLNENGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MON2_HUMAN
Sequence: MSGTSSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDIIEQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRGTWIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITSMIEGELGELETECQTTTEEGSSPTQSTEQQDLQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPVVNVPVPVLIGPISGMSRPFVRTDSIGEKLGRYSSSEPPIVTDELEDLNLWWAAWNTWYRIGSESTKPPITFDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHSAISVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLRVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNENIDVEVVQLISNEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPASRVQNGES
What is the function of this protein?
Plays a role in regulating membrane trafficking of cargo proteins.  Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation.
What are the official names of this protein?
Protein MON2 homolog, Protein SF21.
What is the protein family that this protein belongs to?
Belongs to the MON2 family.
What are the subcellular locations of this protein?
Early endosome membrane.
Protein: SYP_BLOPB
Sequence: MRTSQYLLATLKEAPKNCKAISHQLMLRAGLIRQVSSGLYTWLPTGLRVLRKIENIIREEMSKIGAIEIAMPIVQPARLWKKSGRWTGYGTELLRFKNRNNQEFVLGPTHEEMVSEIICKETMLYKQFPLIVYQIHTKYRDEARPRSGVIRAREFIMKDGYSFHINQKSLQNTYNNMYQTYHTIFNRIGLNFCVVQAEPGKIGGALSHEFQAYSENGEDSIAVPMIPDNNLIDFQLSNDVIPIKIQPKTAVETMQLIAAPNIRSVEELINQFNLPIHQFVKTIIVRAKNKHINNDYSLLGLVIRADHQISLKKIAMIPQIHIPLSCIEPEEIQKITGAQPNLLGPINLSIPLIIDYNVAKMNDFVAGSNMSGKYFFGVNWNRDILFSKVADLHEVLHHNSYTNKKNILSIHNCIEIGHIFQLGQKYLNLHTNYSQKNNEHKHNLSMEMGCYGIGITRIIAVIIEQNYDKNGILWPDVIAPFKLAIIPIDMYRSVNVRNIAEKIYTQLLSVIGIDILIDDRKEYPGTMFADIDLIGIPHILIISDRSLANQEVEYKYRKKNKIEKIKLEMLIRYLIEKIVSS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALKBH_ARATH
Sequence: MYESANVSDDADRTAFRRAEKKYKLYYEQDSKFSRKKKLPKPIDLSELLDFNLISQNFNNDGVLPDGIRVSKVDSSPVFCIDNRPGFYFIPDALSLKEQCKWIKESLTSFPQPPNRTNHNAIYGPIDDLFDSAKENKVLVQDDLTNNKWKFYEEVDIEKATRSSCKSVSASVLLRKLRWSTLGLQFDWSKRNYDVSLPHNNIPDALCQLAKTHAAIAMPDGEEFRPEGAIVNYFGIGDTLGGHLDDMEADWSKPIVSMSLGCKAIFLLGGKSKDDPPHAMYLRSGDVVLMAGEARECFHGIPRIFTGEENADIGALESELSHESGHFFAEYIKTSRININIRQVF
What is the function of this protein?
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation.  Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase alkB, Alkylated DNA repair protein alkB homolog.
Protein: PSTB2_TRIV2
Sequence: MTIFTKNSVPLRARVETMSAFSLPSVNPSRADSEVILHAKVEAFYYDRFLALRNVYLPIYKNLITTLIGPSGCGKSTLLRCFNRLNDLIPQTRLQGQIIFKGRNIYHPLEDAVVLRRNIGMVFQKPNPFPKSIYNNVAFGLRIQGYRGDIDEIVEHSLRQAILWDEVKNKLKENALSLSGGQQQRLCIARMLAVQPEIILMDEPCSALDPTSTKQIEALIKEIKQQHTIVIVTHNMQQASRISDMTAFFNTEMIEGSRTGELVEYDHTPVIFQNPTREITRQYVNGYFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MEND_LISMF
Sequence: MTNHEQVLTDYLAAFIEELVQAGVKEAIISPGSRSTPLALMMAEHPILKIYVDVDERSAGFFALGLAKASKRPVVLLCTSGTAAANYFPAVAEANLSQIPLIVLTADRPHELRNVGAPQAMDQLHLYGSHVKDFTDMALPENSEEMLRYAKWHGSRAVDIAMKTPRGPVHLNFPLREPLVPILEPSPFTATGKKHHHVHIYYTHEVLDDSSIQKMVTECTGKKGVFVVGPIDKKELEQPMVDLAKKLGWPILADPLSGLRSYGALDEVVIDQYDAFLKEAEIIDKLTPEVVIRFGSMPVSKPLKNWLEQLSDIRFYVVDPGAAWKDPIKAVTDMIHCDERFLLDIMQQNMPDDAKDAAWLNGWTSYNKVAREIVLAEMANTTILEEGKIVAELRRLLPDKAGLFIGNSMPIRDVDTYFSQIDKKIKMLANRGANGIDGVVSSALGASVVFQPMFLLIGDLSFYHDMNGLLMAKKYKMNLTIVIVNNDGGGIFSFLPQANEPKYFESLFGTSTELDFRFAAAFYDADYHEAKSVDELEEAIDKASYHKGLDIIEVKTNRHENKANHQALWVKIADALKALD
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: NAR1_ASPNC
Sequence: MSAILSADDLNDFISPGVACIKPVETLPAKDPSKTDNPYEVTTEDKVQPENLPPAQISLTDCLACSGCVTSAEAVLISLQSHAEVLNTLDAHPELPLNREDGTITQELGTASDEGRVFVASVSPQVRASLAATYGITEKEATYMIHQFLSGPHGLRAGGKNGSGFTWVADTNVLREAVLVLTADEVGETLTTSPDSPSTNGATNTLPKRPILSSACPGWICYAEKTHPFVLPHLSRLKSPQALAGTFFKTVLSKSLGIPASRIWHLAVMPCFDKKLEASREELTDASWLSAKDEDHTAVRDVDCVITTREMLSLASSRGISLPNLPLKSLPQSYIPPFPDMTLNDFLFSKSSPGQSAAAGTSGGYLHHVLQTFQARNPGSEIVTQRGRNADVVEYTLMSSEHTPILKAARYYGFRNIQNLVRKLKPARASRLPGGNRRLPVGRGAASGSSGTDYAYVEVMACPGGCTNGGGQIRIEDAREASSSVQSSTSAEVPDSSSKPTPHEQRAWLARVDEAYYSAESDTESEAGSQSQPLSILDKEDKIHNAMRYWSDSMGIPLSKLAYTTYREVESDVGKSQPAATDTTRVAELAGKIGGGW
What is the function of this protein?
Component of the cytosolic Fe/S protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins.  May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor nar1, Nuclear architecture-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: SODM_SHIFL
Sequence: MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHANHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGASGFPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn], MnSOD.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: AMBI3_FISAU
Sequence: MIVSTSVEQSAQFSVKSLTPFGALLEATEDHSDIQQLSIEQLCQLTWEHRLIVLRGFSLLEREELSTYCQRWGELLVWNFGTVLDLIVHQNPENYLFTNGNVPFHWDGAFAEAVPRFLFFQCLKAPEAGSGGESLFCDTVRILQNVSPQQREIWQKTEISYKTQKVAHYGGEITKSLVIKHPITGLSTLRFAEPLNDASVHLNPLYVEVCNLPAEEQNPFINELIENLYLPQNCFAHEWQEGDFLIADNHALLHGRNPFLSNSQRHLQRVHIL
What is the function of this protein?
Involved in the biosynthesis of ambiguines, a family of hapalindole-type alkaloids (PubMed:24180436).  Responsible for the synthesis of Z-3-(2-isocyanoethen)-indole, a biosynthetic precursor to all ambiguines (PubMed:24180436, PubMed:28212039).
What are the official names of this protein?
3-((Z)-2-isocyanoethenyl)-1H-indole synthase.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: GUAD_DICDI
Sequence: MMKANKIIKLFKGTVIHSIEIGKVEILPNSLIGIDEDGVIQHMKSNYEDLKQLEKDVTMICTDNGINEQESVIDMGNKFLIPGFIDTHAHAPQYHNAGTGTDLPLLKWLEKYTFPVESKFKDLIFAENVYGKVVDRMLRHGTTTCCYYATIHLEASELLAEIVSKRGQRAFIGKVCMDRHSPDHYVETTEQSISNTKEFVDRILAKGNPLVQPIVTPRFAPSCTDELMVALGNLSHEKQTLIQSHLSENKDEIEWVKSLYPGIESYTHVYKHFNLLNERTIMAHCVHLSDEEIKLISTQQTAISHCPISNFTLSSGNLDVRKVLEANIKLGLGSDISGGYHPSILQVIRDSIKCSNSHFFNNGNHTPLTFEEAFYLATVGGSKVVNLDHRIGNFIVGKDFDAQIIDPFVQNSPFDCFDGETLKDIFQKFIYLGDDRNLSSLYIKGNKIKF
What is the function of this protein?
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
What are the official names of this protein?
Guanine deaminase, Guanase, Guanine aminase, Guanine aminohydrolase, GAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
Protein: GCS21_LEGPL
Sequence: MPLQPFKTSNLLTMGVELELQLISLSNFDLTAASPDILELLGRSSFPGSFTPEITESMLEIATDVHEEYEQLLKQLFHIRDTLVAVGDRLNIGICGGGTHPFQMWSDQRIFNKTRFIEVSELYGYLTKQFTIFGQHIHIGCEDGNQALFLLHSLNRYIPHFIALSASSPFVQSKDTLYNSARLNSVFAFPLSGRAPFVLNWDEFSLGYFEKMEHTGIVKSMKDFYWDLRPKPEFGTIEMRVCDSPLTVERAAALACYMQALCSYLLENKEPLPHEDDYLVYNYNRFQACRFGLDGTLVHPKTYEQILLREDILTTLRRLKPYANQLNSTMALEHIYEITHKGSDASFLREKYAEHRTLESVVNESLKQFRSSK
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-1, Gamma-glutamylcysteine synthetase 2-1, GCS 2-1, Gamma-GCS 2-1.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: QUEA_ALIFM
Sequence: MQVSDFHFELPDELIARYPQPERTASRLLQLNGNSGELNDGQFTDILDLVQAGDLLVFNNTRVIPARMFGMKASGGKLEVLVERVLDEHSVLAHVRCSKSPKPGTMLLLGENQEHEAEMVARHDTLFEIRFTSDKKVLDILDEIGHMPLPPYIDRPDEDADKERYQTVYNKKPGAVAAPTAGLHFDTEILEKMKAKGVEFAYVTLHVGAGTFQPVRVDNILEHHMHSEYAEVSQEVIDAINATKARGGRVVSVGTTSVRSLESAAQHALKQGTELAPFFDDTEIFIYPGYEFQVVDALVTNFHLPESTLIMLVSAFAGYDNTMKAYEQAVNNKYRFFSYGDAMFITKKTA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHP1_YEAST
Sequence: MESRNTVLPSLPNIITGTSNSPFQLHTLPNTNFPSDDQGDIRLPPLAASAHIVRPVVNIYKSPCDEERPKRKSPQAVDFLSQRVTTSMTPLSKPKKLSSHSPFTPTVRVCSKEQPPQSMHSYKKVNILTPLSAAKAVLTPTTRKEKKRSFAFITHSQETFPKKEPKIDNARLARRKRRRTSSYELGILQTAFDECPTPNKAKRIELSEQCNMSEKSVQIWFQNKRQAAKKHKNSGNTSHCKVHSNDSMSMISYSDAALEITSTPTSTKEAITAELLKTSPANTSSIFEDHHITPCKPGGQLKFHRKSVLVKRTLSNTGHSEIIKSPKGKENRLKFNAYERKPLGEVDLNSFKN
What is the function of this protein?
Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during S late phase.  Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases.  Binds the IMEI regulatory region in vitro, its relevance in vivo is however unclear.
What are the official names of this protein?
Homeobox protein YHP1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y030_SULIL
Sequence: MIKEYYGAETFILNKDFAYILVIGTTDVSLIPGLTIAGATPELTHFTPAADAEYVLLGKCKSINTIPVSPTGIPTPALLTRASLSFINPLKIVVNAGSRILPKIPYIDLQGEPGKDIRKQALSMEKVNNIIENSIKLGEELSNEYELIMIGESIPAGTTTAMATLLALGYDAMDKVSSASPDNPKELKRKVVEEALRNLPTDSLQRLAKVSDPVLLGVAGTSLGFKGKILLAGGTQMTAAAAIINEFDKNKLKDITIGTTKWIVEDKFADMLSLAKQVGVKVLASMLDLSISAYEGIRAYEKGYVKEGVGAGGSAIMALVRGVSNNTLVRKIDELYGELVGSNNLHI
What are the official names of this protein?
UPF0284 protein LS215_0030.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: MRAZ_IDILO
Sequence: MFRGATTLSLDSKGRLAIPAKYRHALSLDCEGKMVCTIDIKQPCLLLYPLPEWQIIEQKLTRLSSMNPAERRLQRLLLGHADDCEMDKNGRLLLSAPLRQHAGLEKKLMLVGQLNKFEVWNEDAWHEQVAQDMDVEREGDFTLNERLEDFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.