PharMolix/UniProtQA huggingface dataset:
Protein: GLMM_THEFY
Sequence: MTRLFGTDGVRGLAGRDLTAGLTLELAIAAAEVLPERGIPGKRPRAVVGRDPRASGEFLEAAVVAGLASAGVDVIRLGVLPTPAVAFLTGELDADFGVMLSASHNPAPDNGIKFFARGGHKLSDEVEDEIERRLGRAVAGATGRDVGRVTDDTDSVERYITHLVNSLPNRLDGLKVVVDCANGAAAGIAPEALRRAGADVIAIGDKPDGFNINEGCGSTNLDALRAAVLEHGADAGIAHDGDADRCQAVAADGSVVDGDQIMAVLALELYEANALHNNTLVVTVMSNLGLKLAMKEAGITLVETQVGDRYVLEAMRAGSYSLGGEQSGHIILLDHATTGDGLLTGMHLLAAVNRRGVALAELAKVMNRLPQVLVNVSGVDKTRVATSERIAAEVAAAEAELGDSGRVLLRPSGTEPIVRVMVEATSQDRAQAIADRLADVVRDELSINA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RS10_LACCB
Sequence: MAKQKIRIRLKAYEHRILDQSADKIVETAKRTGATISGPIPLPTERTLYTVLRSPHKYKDSREQFEMRTHKRLIDIVNPTPKTVDALMKLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ZUPT_CLOPE
Sequence: MKGGDNMNNVLMAFLLTLLAGLATGIGSCIAFFAKKTNKKFLCVSLGFSAGVMIYVSMIEMFQTAKESLVGVMGIKAGNWITVISFFAGIAIIALIDKFVPEEENPHEVRSVEEVENEIEEYKGENKEGKADIKDKTLMRTGIVTALAIAIHNFPEGLATFVSALEGASLAIPITIAIAIHNIPEGISVSVPIFYATGDKKKAFLYSFLSGMSEPIGAIIGYTLLRNIFNDITLGILLSAVAGIMVFISLDELLPTARKYGEHHLAIYGLIAGMVVMAVSLLLFI
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RMF_KANKD
Sequence: MKRQKRDKLQRAHTKGFNAALQGQSKENCPFEELNAREEWLGGWREGREAFTTNGMKAYI
What is the function of this protein?
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).
What are the official names of this protein?
Ribosome modulation factor, RMF.
What is the protein family that this protein belongs to?
Belongs to the ribosome modulation factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_SORC5
Sequence: MNFSAILLLALGLAMDATAVAAARGLSVPAIRARHVLLVAGFFGGAQALMPVIGWLLGARIGPRVQAWDHWIAFVLLAFIGGKMLWEARGDGGDDGGEGETTADPFALSAMFVLAIATSIDALAVGITLPMLNAPFAISVVTIGVVTALLSAAGLFAGRRFGALLGKRLDLAGGVVLIGLGFKILLEHLVLS
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y7021_BURL3
Sequence: MLRYAVIFFIIAIVAAVFGFGGIAAGAAEIAKILFYIFVVIFLVTLLLGVVRR
What are the official names of this protein?
UPF0391 membrane protein Bcep18194_C7021.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NEMP2_CHICK
Sequence: MGPRRLPWARPGPALGLLLLALAGAVPAAGGSCSLLEEGNTIQKLHEDCFCYVQNRTMHLQYIWSTVQVKINSTRTFRFVPTPEKSNCRNSETVFEFAACAVQILWRPETSTETFLKIKQYGEDFCFRIQPFKEELYTVSMTREMLDGKLLFLFAAGIFLFHFANSLSRSTNFFYLSGIILGVLALLVFVLLALKRFIPRRSTFWILLSGCWMSSLYLIYCFKENMQWLWSEHRIYVLGYFVAVGTLSFATCYQHGPLTSELSITLFTWTLQLTAFVFIYCGVNIPQVAYAIIAVKPSPKGLGYPPAAAWHIGRKMKNHFQSKKVVVRCLTEEEYREQGETETVRALEELRSFCKNPDFSSWLAVSKLQSPHRFAGFVLGSPHVSPAETKAHDEEYGIGSSFLEEQLFETRTESEQDETTSYIHEGDDENEDEIHEPISFPYATELL
What are the official names of this protein?
Nuclear envelope integral membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the NEMP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side.
Protein: DPOL_HBVC3
Sequence: MPLSYQHFRKLLLLDDEAGPLEEELPRLADEGLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTVPVFNPEWQTPSFPHIHLQEDIINRCQQYVGPLTVNEKRRLKLIMPARFYPNLTKYLPLDKGIKPYYPEHAVNHYFKTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHGRLVFQTSTRHGDESFCSQSSGILSRSPVGPCVRSQLTQSRLGLQPQQGSLARGKSGRSGSIRARVHPTTRRSFGVEPAGSGRIDNRASSTSSCLHQSAVRKTAYSHLSTSKRQSSSGHAVELHNIPPSSARPQSEGPILSCWWLQFRNSKPCSDYCLTHIVNLLEDWGPCTEHGEHNIRIPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGSTHVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLVGSSGLPRYVARLSSTSRNINYQHGTMQDLHDSCSRNLYVSLLLLYKTFGRKLHLYSHPIILGFRKIPMGGGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLFTSITNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGCWGTLPQEHIVLKIKQCFRKLPVNRPIDWKVCQRLVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRSGLCQVFADATPTGWGLAIGHSRMRGTFVAPLPIHTAELLAACFARRRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLHLPFRPTTGRTSLYAVFLSVPSHLPVRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: RASFA_HUMAN
Sequence: MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV
What is the function of this protein?
Plays an important role in regulating embryonic neurogenesis.
What are the official names of this protein?
Ras association domain-containing protein 10.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.
Protein: GFLB_DICDI
Sequence: MTDLNSESFSALNFWKSVEKKNISTNFQGTKVVAPSKKINSFPLLAPPAPPPPPTEQEINIGSGNSTFISSNNNNSNNNNNNNSNNNNNNNLNNSNNNNNNLNSNNNNNNNNNNNNNNGNNNNNSNFLTRQDSSTQKEWDEQNVTEAFGFWKQKAVQLQKETERYNARRNARQTIDLTNILRKSTSSDLLIKPPVESPPLTPVGQDDEGEQQQQQQQQKQSSPSTPSNDTDTETTAAAVTTTTTTTTTTTTSTTTTTTETVLQANQLEIKYGGETIAVVDDSGTTPRDYRRSRSISCEIIPKINGVITTSPQRVTTTTTTTTPSTGGVVVADEESDSSEEESDSSEEESDEYTDEESETELQVVSNATPRRSDDFTPTIVESPPLTSVNSNDNTSSGTVVAPIDLNSSTGGNTGSQQPPQPSSQQQKPDQASENTAVAASSISATTNVTSAASTTTVAPDSIINTKDVTVVSSTLTTTTSATSSTTSATTQSIPAPPSPSQQRAAQSISTSSVTPAAITKPTKDAKDKKDPAKKSIGATLTRTVTKTFIRDSKENNKVPTGTSPPVSSSTSISSSTGIKKDKVKLSKEEKDRIKKEKSAKKKKEKDEKKQQKTNKKALTKNNSSTDVKKGFVSPQQQQILDSPYRIYGVRLTQLVLSNDGDLPAILTQTITVLSNSNKLDVNSVFVGAENEPAVREIRKRSDLERIDFSIIGDPRVVAGLLILFFAELPQPLFNSKFFGDLVEINDITNPQVKLNDLKQLINSLSQLRRSLLQILVTFFTSKYINGNSVTTRAIAIQSIAQSFGPQFFRGTSSSDSDIQVGIETLKLIIDNYVFLFEKTNEPDVKYKNIDGKMIISEGSIDKLIDKATDQYYPYNEKYFSLTFFITHLFFIQPHELADKLITLYRENLDTLETKKKWKKHRRSKKASFINEAVKLWVDYCYKEMREDKELSKKILKGFPHLEAQLASRLSHRTTINDFLKLPKRVHSRTRSASFSDTLLSTGGIGSTSGGIGGGVNNCLLSAMEIAEQCTLVDYDLFTNVRLSDWVRLVQGSVDPQTAPSLSLALKRSTIWAQWAMGEILSTEDKSQRVAIINLLVDVAINCKDLANFNTAISIHTALTNHHIKRLQQTWDSVPKETLNKITQLEQSLQVWLKPDATNPFGVICQSINSACVPNFSILRTILSQIDQKIPTFSNDGSMVNVEKLRTIFGIVVEIQRLQQQRNYTMKPTKLFIQLQDINTVSMDELADLSLKCEPPVSKAKKYNAPADIVDEDWRLKITKTFNKPLATTSVGIDLPRLASSFTFNTTGHKTTPEEKSAYGNKIQDIFHVLVSLAQIESSELETDVREKFTTYIPMSTDPDSDFKRELLKFLDEVCHADNSKLVRVLKCCNQAIIAPVIIEITLNIAKGVPFMDAGGWRILISNINNSNNSVILDKIDEINEDSSNVEKEKLSSSQEQQEQQEQKQQEQQQQQQEPQPLFIRHYKKQRSRSAQSKDFFEFEWFIQLNLDADCKNILSFDLKISNLVFSTDTSPNIRDQLLESFKSYLVSQECVQYINFNENKQPVAAPVTPATTIVTTKEESTTVTSSTTTVVQESVPSTNAE
What is the function of this protein?
GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells (PubMed:27237792, PubMed:29626371).  Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways (PubMed:27237792).  Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways (PubMed:28778987).
What are the official names of this protein?
Ras guanine nucleotide exchange factor glfB, GEF-Like protein B.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium. Note=During chemotaxis, localizes at the leading edge of cells, whereas in response to cAMP stimulation, rapidly and transiently translocates to the cortex (PubMed:27237792). Localizes to F-actin-rich regions (PubMed:28778987). During macropinocytosis, strongly localizes to crowns and remains there for a short time after the cups were enclosed (PubMed:28778987). During phagocytosis of heat- killed yeast, strongly localizes to phagocytic cups with F-actin (PubMed:28778987). During cytokinesis, mainly colocalizes with F-actin at filopodia or lamellipodia of daughter cells (PubMed:28778987).
Protein: TRMH_AQUAE
Sequence: MVMEYLVLEKRLKRLREVLEKRQKDLIVFADNVKNEHNFSAIVRTCDAVGVLYLYYYHAEGKKAKINEGITQGSHKWVFIEKVDNPVQKLLEFKNRGFQIVATWLSKESVNFREVDYTKPTVLVVGNELQGVSPEIVEIADKKIVIPMYGMAQSLNVSVATGIILYEAQRQREEKGMYSRPSLSEEEIQKILKKWAYEDVIKERKRTLSTS
What is the function of this protein?
Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.  Type II methylase, which methylates only a subset of tRNA species.
What are the official names of this protein?
tRNA (guanosine(18)-2'-O)-methyltransferase, tRNA [Gm18] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: MURR_SHIB3
Sequence: MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNTTALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVASLKMIQRSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: PSBF_NOSS1
Sequence: MTSGNNINQPVTYPIFTVRWIAVHTLAVPTVFFLGAIASMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: DCAM_CATRO
Sequence: MALPASAIGFEGYEKRLEISFFESSFFADPDGKGLRALNKSQIDEILEPAECTIVDSLSNQYLDSYVLSESSLFVYPYKIIIKTCGTTKLLLSIPAILKLAESLSLSVRNVKYTRGSFIFPGAQSFPHRSFSEEVELLDNYFGKLGLESNAFIMGNPDQPQKWHVYSASVGSEQSSDPTYTLEMCMTGLDREKASVFYKSESSSAALMTTRSGIRKILPDSEICDFEFDPCGYSMNSIEEAAISTIHVTPEDGFSYASFEAAGYDLKAQNLGMMIERVLACFQPSEFSVAVHCDVTCKSLEQICSLELKEYSLDEKINEELGLGGSIIYKKFLRIDACGSPRSILKCCWKEDESEEE
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: CCRM_BRUA4
Sequence: MSLVRLAHELPIEAPRTAWLDSIIKGDCVAALERLPDHSVDVIFADPPYNLQLGGDLHRPDQSMVSAVDDHWDQFESFQAYDAFTRAWLMACRRVLKPNGTIWVIGSYHNIFRVGSQLQDLGFWLLNDVIWRKTNPMPNFRGRRFQNAHETLIWASRDQKGKGYTFNYEAMKAANDDVQMRSDWLFPICTGSERLKDENGDKVHPTQKPEALLARIMMASSKPGDVILDPFFGSGTTGAVAKRLGRHFVGIEREQSYIDAATARIDAVEPLGKAELTVMTGKRAEPRVAFTSVLEAGLLRPGTVLCDERRRFAAIVRADGTLAANGEAGSIHRIGAKVQGFDACNGWTFWHYEENGALKPIDALRKVIRDQMAVAGA
What is the function of this protein?
A beta subtype methylase that recognizes the double-stranded sequence 5'-GANTC-3' and methylates A-2 on both strands (PubMed:12654995) (By similarity).  CcrM-mediated methylation has important cellular functions.  Contributes to the accurate cell-cycle control of DNA replication and cellular morphology (By similarity).
What are the official names of this protein?
DNA methyltransferase CcrM, M.CcrM, Adenine-specific methyltransferase BabI, Type II methyltransferase M.OanORF605P, M.OanORF605P.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: RL24_STRR6
Sequence: MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKHQRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LEUD_PYRHO
Sequence: MITTGKVWKFGDDISTDEITPGRYNLTKDPKELAKIAFIEVRPDFARNVRPGDVVVAGKNFGIGSSRESAALALKALGIAGVIAESFGRIFYRNAINIGIPLLLGKTEGLKDGDLVTVNWETGEVRKGDEILMFEPLEDFLLEIVREGGILEYIRRRGDLCIR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: CCR5_ALLSO
Sequence: MVYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTIPFWAHYAAAQWDFGNTMCQLLTGLYLIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGLVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPSSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHLAKRFCKCCSISQQEAPERASSVYTRSTGEQETTVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL33_METC4
Sequence: MAKAVTVKIRLVSTADTGYFYVTKKNSRTQTEKMVMKKYDPVARKHVEFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: G6PI_PARD8
Sequence: MKNISLNIDKALGTVSKEQVYAQEAKAMECIATLHNGNGAGNDFLGWLHLPSSITDAELADIENTANVLRSKCEVVVAIGIGGSYLGTKAVVEALNNSFDWLQNDRKNPVMLYAGHNIGEDYLYELSEVLKGKQFGIINISKSGTTTEPALAFRILKKQLEDAVGKEEAKHRIVAITDAKRGALRTLADQEGYKTFIIPDNVGGRFSVLTPVGLLPIAVAGISIRDLVAGAVSMEKATDASVPFADNMAAIYAATRNELYKNGKKIEILANFHPKLHYIAEWWKQLYGESEGKDGKGIFPASVDLTTDLHSMGQWIQDGERTIFETVISVEATDHSVLVPTDEADLDGLNFLAGKHVDEVNKMAELGTQLAHVDGGVPNIKVNMPEVSAFYIGQLFYFFEKACGISGYMLGVNPFNQPGVEAYKKNMFALLNKPGYEKESEAIKARL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_PSET1
Sequence: MIKNANIHFNHQGTPVANDFDDIYYSDDNGLAESYYVFYQQNNIDTRLQSHDQAHFVIAETGFGTGLNFLNTCQHFTDHLARQQVQKQLNYGVKRLHFIAFEKHPLSVSDLSKILTAWPELNLLSEQLISQYPINLAGCHRLEFNNGTIVLDLYFGDALESIKTMSYPRSGIVDAWFLDGFAPSKNPDMWQQSLFNAMVNISKVGATLATFTAAGFVRRGLSDAGFTMQKVKGFAHKRSMLIGTLKHTNDTQSAPSYFNHDVSPLSNVAVIGGGIASSCILYSLAKRGISSQLFCQDAAPAMGASHNVQGAVYPHLQAKNSPHSELFAHSFLYAKRLYKQLLNDGFSFDHSWCGVLQHAVKQPLVDRHENLAQQQLWPQTLMRNVTAEQGDTIAGVTTGYSGVYFEQGGWVNPPQLVNAMLSAAHCLSPYKSTFNCHIEQLKKTSNGWLLFSNGKQFGPFSDVIICAGEHSDAFAQTKALPIVGVRGQVSHVQASEQSTKLKTVLCHKGYFTPAYLDHHCMGATFEKNTKSRQVTEQDNLSNREQLLNFYGHCNFATSLGNITAAKAAVRCSFIDHLPMAGEWVEQSDYLTAFANLRLGKRYQYQALSKKQQGLHIFTGFGARALCSAPLCSEHLISSLNNEPRPLSERVSQAIHPARFIVRDLIRNKI
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYNX1_SAIBB
Sequence: MTPLLTLFLVALIGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPSCFETVYDGYSKHASTTSCCQYDLCNGAGFAAPATLALAPILLATLWGLL
What is the function of this protein?
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs).  The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration.  Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization.  Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs.  Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum.  Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR.  In vitro modulates alpha-3:beta-4-containing nAChRs.  Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode.  Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs.  Prevents plasticity in the primary visual cortex late in life.
What are the official names of this protein?
Ly-6/neurotoxin-like protein 1.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Cell projection, dendrite. Endoplasmic reticulum. Note=Detected in Purkinje cells soma and proximal dendrites.
Protein: NDUA2_PONPY
Sequence: MAAAAASRGIGAKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQEKNVPLNNFSADQVTRALENVLKPEASTED
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2, Complex I-B8, CI-B8, NADH-ubiquinone oxidoreductase B8 subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA2 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TAL_CUPNH
Sequence: MNQLEQLRQFTTVVADTGDFQLMKQYTPQDATTNPSLILKAVQKPEYRHLLEKAVQDHHGNGGVDAVMDEVLIAFGCEILAIVPGRVSTEVDARLSFDTEASVAKARHLIQLYEQRGIARERVLIKIASTWEGIRAAEILQRDGIRCNMTLLFSLVQAVACAEAGAQLISPFVGRIFDWYKKQAGEQWDAAANGGDNDPGVRSVRQIYDYYKKFGYPTEVMGASFRSTTQILSLAGCDLLTISPELLEQLAAGQGPVAHKLSVDQAQAANIARIAADEPAFRWQLNEDAMATEKLAEGIRLFAADAVKLEKLIGEIAK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBIJ_PRIMG
Sequence: MILLLAGTSDARALAVQVKKAGYDVTATVVTDNAAIELQRAEVKVKIGRLTKEDMTDFINEHGVKAIVDASHPFAEEASKNAIGAAAETAIPYIRYERASQAFTYDNMTMVSTYEEAAEVAAEKKGVIMLTTGSKTLQVFTEKLLPLSDVRLVARMLPRLDNMEKCQQLGLPQKNIIAIQGPFTKEFDRALYKQYGVTVMVTKESGKVGSVDKKVEAAKELGLDIIMIGRPKIEYGTVYSTFEEVVHALVNQTRS
What is the function of this protein?
Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.
What are the official names of this protein?
Cobalt-precorrin-6A reductase.
What is the protein family that this protein belongs to?
Belongs to the precorrin-6x reductase family.
Protein: METN2_PSEE4
Sequence: MIEFQNVHKTYRVDGRDIPALNPTSLTIEDGQVFGLIGHSGAGKSTMLRLINRLEAPSGGKIIVDGEDVTAFDANQLRRFRQQVGMIFQHFNLLASKTVADNVALPLVLAGELSRGEIDKRVTELLARVGLQDHARKYPAQLSGGQKQRVGIARALSTNPKILLCDEATSALDPQTTASVLQLLAEINRELKLTIVLITHEMDVIRRVCDRVAVMDAGKIVEQGPVAEVFLHPEHPTTKRFVQEDEQVDEGEQRDDFAHVPGRIVRLTFQGDATYAPLLGTVARETGVDYSILAGRIDRIKDVPYGQLTLALIGGDMEAAFARFKAADVHMEVLR
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.