PharMolix/UniProtQA huggingface dataset:
Protein: UAP1_CAEEL
Sequence: MTITAPPKDEIISKFPGSEPLLNFYNELSDAEKSKLFHQISTLNLSEAHQWFIDSADQRAPSTAEDLKPVLDSQHFVQAELHQVILDGLWNKGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINASFGDSLLGIQAAKIALLQALAGEREHQNPGKIHWAVMTSPGTEEATREHVKKLAAHHGFDFDEQITIFSQDEIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAISAHLPRLRAKGIKYFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQKGELVGSVCLDRGLPRVVEYSELGAELAEQKTPDGKYLFGAGSIANHFFTMDFMDRVCSPSSRLPYHRAHKKISYVNEQGTIVKPEKPNGIKLEQFIFDVFELSKRFFIWEVARNEEFSPLKNAQSVGTDCLSTCQRDLSNVNKLWLERVQAKVTATEKPIYLKTIVSYNGENLQELRHREISDSALESDHSINKFFVV
What are the official names of this protein?
Probable UDP-N-acetylglucosamine pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_BORHD
Sequence: MARIAGIDLPNNKQLQIALTSIYGIGRARALEICEKTGVLPDKRAKELDNDEVNKLRKIIESDYVVEGKLRSELAMSIKRLMDIACYRGLRHRKGLPLRGQRTKTNARTRKGKRKTVANKKMASK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: Y0031_DROME
Sequence: MLKFVILLSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQSVSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSNPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAAASGKDACQGDSGGPLVSGGVLVGVVSWGYGCAYSNYPGVYADVAALRSWVISNA
What are the official names of this protein?
Trypsin delta/gamma-like protein CG30031.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RSMH_CAMJD
Sequence: MEIPHIPVLLNEVQEIFKNLKTGYFLDCTLGFGGHSETLLKNHPGLKFIACDQDQQALEFSKKRLKDFHNRITFIQSNFSEVLEKISHKEELRGILADIGVSSFQLDNNERGFSVNSDFLDMRMNQNSKISAYEVVNAYTKEQLTSIFKDYGELHDAHFIAEKICLERSKNLIKSAKELYQIIGKGKQNHRKISKATLAFQAIRIEVNQELKVLKDFLGYLENLKPKNCILAIISFHSLEDRIVKNFFKKWSKNCICDEKIMRCKCGNNHSLGQIITKKSISASKEELLKNSRSSCAKMRAFYFNNLDNK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCP_MOUSE
Sequence: MTAAPLMPDSTHPCRRRKSYTFFWCSLGVYAEALLFLLSHLSDACELPRPFEAMELKGTPKLFYAVGEKIEYKCKKGYLYLSPYLMIATCEPNHTWVPISDAGCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREGIFSQELDAWIIALIVITSIVGVFILCLIVLRCFEHRKKTNVSAAR
What is the function of this protein?
May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
What are the official names of this protein?
Membrane cofactor protein.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: RBL_BYRCR
Sequence: VGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAQYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFPAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GCSP_BURA4
Sequence: MKLEHPDRLMNRTPLSLAALETHDAFAERHIGPDAASQQAMLDTLGFASRAALIDAVIPASIRRAETLPLGPFAQPKSEAEALAALRALADKNQVFRSYIGQGYHDTHTPAVILRNVLENPAWYTAYTPYQPEISQGRLEALLNFQQMVADLTGLAISNASLLDEATAAAEAMTLLQRTGKPASNVFYVADDVLPQTLEVIRTRALPIGIEVKTGPAADAAQANAFGVLLQYPGVNGDVRDYRALTEAIHAAGGHVVVAADLLALTVLTPPGEWGADVAVGNTQRFGVPMGFGGPHAAYLAVRDEFKRQMPGRLVGVTVDAQGKPALRLALQTREQHIRREKATSNVCTAQALLAIMASMYAVYHGPHGLKTIALRVNRIAALFAAGVKQLGFATVNDTFFDTLTIDTGARTAQVHEFAKARRINLRRVSATQVGVSFDETTTRDDLAALLAVFAQAAGGTAPSVDALDAGAAGVAALPAGLERTSAYLTHHVFNRHHSETEMLRYLRSLSDKDLALDRSMIPLGSCTMKLNATSEMLPVTWPEFGRIHPFAPAEQTVGYREMIDQLEQMLVAATGYAAVSLQPNAGSQGEYAGLLIIHAYHASRGEAHRDVCLIPASAHGTNPASAHMAGMKVVVVACDAQGNVDIADLKAKAEQHANDLAAIMITYPSTHGVFEQNVREICEIVHAHGGQVYVDGANMNAMVGLTAPGQFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVGAHLAKFLPNQRSTGYTREEDGIGAVSAAPYGSASILPISWMYIAMMGAKNLTAATETAILNANYIAKRLAPHYPVLYSGPGGLVAHECILDLRPIKETSGISVDDVAKRLMDYGFHAPTMSFPVPGTLMVEPTESESQEELDRFIAAMIAIREEIRAVEEGRADREDNPLRHAPHTAAVVTANEWPHAYSREQAAYPVASLGTNKYWPPVGRADNAYGDRNLFCSCVPMSDYA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: WNT4_PLEJO
Sequence: SGSCEVKTCWKAMPPFRKVGNVLKEKFDGATEVEQKKIGSAKVLVPKNSQFKPHTDEDLVYLDSSPDFCDHDLKNGVLGTAGRQCNKTSKAIDGCELMCCGRGFHTEEVEIVERCSCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Plays an important role in embryonic development (By similarity).
What are the official names of this protein?
Protein Wnt-4.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: SYA_METVS
Sequence: MEITHDYKVKLFEEMNFERKQCSECKQWFWTLDKERITCGDSPCDKYSFIGNPITTKKYTYNEMVKEFTNFFDERGHSPVKRSPVIAKRWRDDILLTIASIAVFQPWVTNGLVKPVKNPLVITQPCIRLNDIDNVGRTGRHLTCFTMGAHHAFNSKDEYKYWTDKTVELCFELMQKLGIDGHTITFIESWWEGGGNAGPCYEVITHGVELATLVFMQYKKVGNNYEEIPLKIVDTGYGIERFAWASQGTPTVYEALFSDIIEKLKKNANIPIVDEKIMAESATLAGLMDIENVGDLKALRQKVAEKIGMDVNELDRLISPLEYIYAISDHTRCLSFMFGDGIVPSNVKEGYLARLVLRKTLRYMEKVGISYSIKEIILMQLESMKEVYPELIGMKDYIMDVLDSEEKKYIQTVNKGRGIVERMTKLKSEITLNDLINLYDSNGLPPEIVKDIIDEINKTSKTKISIHVPDNFYTIVAERHEEEKAEEVAILKHELPELDLPKTELLFFKNTMQSEFEAKVLKIVDKYIILDRTVFYAEGGGQKYDIGQISGVDVVDVQKKNGIVFHKVLDISKFKEGNLVKGELNFENRLKLMRNHTATHVINAALKQVLGKHVWQTGSNVDTEKGRLDVTHYERISRKEIKEIEKIANEIVLLGKPVTCKFMDRNDAEQEYGFKIYQGGVVPGDTLRIVEIDGIDVEACGGTHVTNTSEIGYIKVLKTERIQDGVERLEYSTGMGSIFEIAALEDILLDSAEVLGVPIENLPKTAKRFFEEWKEQKKVIEELQKKVGELLKYELLEKFEKVGNLEILVEKVSGTSNELMAIADNLATNGKIVILMNDTDYILCKKGENVEISMKELIQKIGKGGGKENLAQGKYSTSKEQIREKAFELLKQ
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FZD10_CHICK
Sequence: MGPAAGNLVRAVLALCWLAEHCAGISSIDIERPGDGRCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPPRGSSMLPPMFRPQRPSTGHDLQQHKDSLSRTSCENPGKFHHVEKSASCAPLCTPGVDVYWSKDDKQFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYSVGYIIRLFSGAESIACDRDSGQLYVIQEGLESTGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGLCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKIVASQQKCKMNNQTKNLDCMMNNSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVCSRRLKKRSRRKPASVITSSGIYKKPQHPQKTHLAKYESTLQPPTCV
What is the function of this protein?
Receptor for Wnt proteins.  Functions in the canonical Wnt/beta-catenin signaling pathway.  Activation by WNT7A induces expression of beta-catenin target genes (PubMed:11142678).  The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:11142678).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
What are the official names of this protein?
Frizzled-10, Fz-10, cFz-10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROK_THISH
Sequence: MTQTSNIILIGPMGAGKSTIGRQLAAALHLPFRDSDKEIEKRTGVDIPTIFEFEGEEGFRNRESAMLEELCTEQGIVLATGGGAVMRPQNRALLRDCGLVVYLKTSVKTQLRRTARDRNRPLLQTENPRARLEELMRIRDPLYREIAELTVDTDRDSIRKVVQEISRYYRMNNKDSIPQDDSNTEPQGDG
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_MYCMM
Sequence: MNVAPEPGAAGAAAPQGRKLLRLEVRNAQTPIERKPPWIRTRARMGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAPLDRDEPRRVAESVHTMGLRYATVTGVARDDLPDGGAWLYAETVRAIKELNPSTGVELLIPDFNGKADQLGEVFEARPEVLAHNVETVPRVFKRIRPAFTYQRSLDVLTAARQFGLVTKSNLILGMGETPEEVRTALVDLHDAGCDIITITQYLRPSPRHHPVERWVRPEEFVEFAQYAEGLGFAGVLAGPLVRSSYRAGRLYEQARSRNTSGASNSG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK2_PEA
Sequence: MATETFLFTSESVNEGHPDKLCDQISDAVLDACLEQDPESKVACETCTKTNMVMVFGEITTKANVDYEKIVRDTCRNIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEDIGAGDQGHMFGYATDETPEFMPLSHVLATKLGASLTEVRKNGTCPWLRPDGKTQVTVEYYNDKGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFRHGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVREAAKSIVANGLARRCLVQVSYAIGVPEPLSVFVDSYGTGKIPDREILNIVKEAFDFRPGMISISLDLLRGGNGRFFEDSCIWTFW
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BZP18_ARATH
Sequence: MEDPSNPQPNQSNLSQCPPLATAPTPAPVRGPYHRRAHSEVQFRLPEDLDLSEPFGGFDELGSEDDLFCSYMDIEKLGSGSGSASDSAGPSAPRSDNPFSAENGGAEAGNSRPRHRHSLSVDGSSTLESIEAKKAMAPDKLAELWVVDPKRAKRIIANRQSAARSKERKARYILELERKVQTLQTEATTLSAQLSLFQRDTTGLSSENTELKLRLQVMEQQAKLRDALNEQLKKEVERLKFATGEVSPADAYNLGMAHMQYQQQPQQSFFQHHHQQQTDAQNLQQMTHQFHLFQPNNNQNQSSRTNPPTAHQLMHHATSNAPAQSHSYSEAMHEDHLGRLQGLDISSCGRGSNFGRSDTVSESSSTM
What is the function of this protein?
Transcription factor that may participate with bZIP34 in the gametophytic control of pollen development.
What are the official names of this protein?
bZIP transcription factor 18, AtbZIP18, bZIP protein 18.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Cytoplasm.
Protein: GTHB2_CTEID
Sequence: TGTPVKILVVRNILLLLFCLVVLLVFAQSSFLPPCEPVNETVAVEKEGCPKCLVFQTTICSGHCLTKEPVYKSPFSTVYQHVCTYRDVRYETVRLPDCPPGVDPHITYPVALSCDCSLCTMDTSDCTIESLQPDFCMSQREDFPVY
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Gonadotropin subunit beta-2, GTH-II-beta, Gonadotropin beta-II chain, Luteinizing hormone-like GTH.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: PA14_POLDO
Sequence: ADDLTTLRNGTLDRGITPDCTFNEKDIELHVYSRDKRNGIILKKEILKNYDLFQKSQISHQIAILIHGFLSTGNNENFDAMAKALIEIDNFLVISVDWKKGACNAFASTNDVLGYSQAVGNTRHVGKYVADFTKLLVEQYKVPMSNIRLIGHSLGAHTSGFAGKEVQRLKLGKYKEIIGLDPAGPSFLTSKCPDRLCETDAEYVQAIHTSAILGVYYNVGSVDFYVNYGKSQPGCSEPSCSHTKAVKYLTECIKRECCLIGTPWKSYFSTPKSISQCKRDTCVCVGLNAQSYPAKGSFYVPVEKDAPYCHNEGIKL
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (By similarity).  May act as an allergen and induce hemolytic activity (By similarity).
What are the official names of this protein?
Phospholipase A1 4, PLA1 4.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: HXB1A_TAKRU
Sequence: MDNMNSFVEYSICNRPATGAYSVPKSGYHSHHHLHHHHHPLDQNQGFPVTTGSFHTGLAASPAAVNGSRTDSSAPGAVYNPDGRLYGTAGEEGAHGATGTSQHHHQHPHHFPEQQPEQNGYSHPHLQTQTLQSGTLSHYNHGSSGSAYAGQSCARNSEYASTNTIHSHYYMEEPAASTYYHQSSFTSTAPTVGPSYGALAGAYCGPQGALAGSQYPQQLVGGLDAAGYLGLPQGGYGEPQTTQERERGGEEGQQAGQGQTFDWMKVKRNPPKTVKVSDFGLAGAHNSAIRTNFSTRQLTELEKEFHFSKYLTRARRVEIAATLELNETQVKIWFQNRRMKQKKREREGGCATPRTPSSSGFNKELEDTDHSSTSTSPGASPSSETSSERAA
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B1a.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNLJ_HAHCH
Sequence: MSEVPAAIQEELNTLRETINDHNYRYYTLDDPSIPDAEYDRLMRRLREIEAEFPQTITPDSPTQRVGAAPAEGFETVSHRLPMLSLDNAFEEQDLLDFDRRVRERLKEAEDARIDYCCEPKLDGIAISLLYRDGYLVRGVTRGDGSAGEDITANVKTVKNIPLKLRGEGYPAELEVRGEIYLPKAAFDAINKDAAAKGEKTFVNPRNAAAGSLRQLDPRITAKRALEMCCYSVGYFEGELPGTQHDILTQLQQWGLKINSQMKLASGAQECLDYYRHIMSVRDQLPYEIDGVVFKVNRIDLQQELGFVSRAPRWAIAHKFPAHEEMTELLAVDFQVGRTGAVTPVARLKPVFVGGVTVSNATLHNMDEIRRLDVHIGDTVIIRRAGDVIPQVVSVVQDRRPENAVPVDRPEHCPVCGSDVLQLEGEAVARCSGGLYCSAQRKEAIKHFASRKAMDIDGLGDRLVELLVEKELIDSPASLYSLKAPDVAGLERMGEKSAQNLINAIEASKQTTFARFIYALGIREVGEATAKVLAQHFPTLDLLKQATEEDLVEAPDIGPISAGHIRSFFQQEHNLETIDALLNQGVSWPEVVVRSTETLPLSGQTAVVTGVLADYSRDEAKDLLTRLGAKVSGSVSAKTGFVVAGEKAGSKLTKAQDLGVKVLDEDAFKQLLEEHQAHLGGEA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: URE2_SYNS3
Sequence: MAPLIPGELLAEPGELELNANREVTTLTVANSGDRPVQVGSHFHFQEANAALIFDRDAARGQRLDIPAGTAIRFEPGDNRDVNLIPFSGARRVVGFNGNINGPLDA
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y209_LISIN
Sequence: MAKANEHFFYVLKCSDNSYYGGYTTDVMRREAEHNAGIRCKYTKTRRPVKVIHFEKFETRSEATKAEAAFKKLSRKNKDSYLSEREEESK
What are the official names of this protein?
UPF0213 protein lin0209.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: ULK3_MOUSE
Sequence: MAGPSWGLPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPARRISFKDFFAHPWVDLEHMPSGESLAQARALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTVQELLREMARDKPRLLAALEVASAALAKEEEAGKEQDALDLYQHSLGELLVLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSSCTLQ
What is the function of this protein?
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.  Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3).  Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.  Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.  Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to pre- autophagosomal structure during cellular senescence.
Protein: HIS4_THEMA
Sequence: MLVVPAIDLFRGKVARMIKGRKENTIFYEKDPVELVEKLIEEGFTLIHVVDLSNAIENSGENLPVLEKLSEFAEHIQIGGGIRSLDYAEKLRKLGYRRQIVSSKVLEDPSFLKSLREIDVEPVFSLDTRGGRVAFKGWLAEEEIDPVSLLKRLKEYGLEEIVHTEIEKDGTLQEHDFSLTKKIAIEAEVKVLAAGGISSENSLKTAQKVHTETNGLLKGVIVGRAFLEGILTVEVMKRYAR
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_LEGPC
Sequence: MRKVKPKLNLTSQTARIVNLSHDGRGIARVNGKATFIQGALPGEVVEFQYTRIKKDFDEGKLLSIVEPSTLRVEPKCPHYQMCGGCSLQHMSAEEQIRFKQSHLLDLLSRYGHTEPQSVLSPLTSHHWNYRNKARLSTRFVEKKQSTMVGFRERNNPRFITEINQCPILNSKIDTDIVHLRKLIDTMEDKHCIAQIEVAAGDNEVALIFRNLSPLTEQDELKIREFAQQFQYKVFLQPGGLDSVFCFYPSDAHAYLSYELPDYQITFQFHPNDFTQVNAELNRKMVTQAIQLMELKNSDIVLDLFCGLGNFSLPMAKHCSRVIGVEGNKNMVERAYMNAKSNHITNVDFYAANLDDVMEVRNLVNTSFSKVLIDPPRSGALEIVKQIDSIDPERIVYVSCNPITLARDTDILVNQKGYVLITAGVMDMFPHTAHVESIALFQKG
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: PPK5_PANSB
Sequence: GGETSGEGKGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, FXPRL-amide, PanS2-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRGBP_HUMAN
Sequence: MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
What are the official names of this protein?
MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4.
What is the protein family that this protein belongs to?
Belongs to the EAF7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIGB_PECCP
Sequence: MWLRVCTFLIIIVGGISGFSAVAGVCPDWDNTRSKKEIDALRQQLEQWDDVYYTEGKSPVADDVYDQLREQLNQWLGCFQPQSVASVRLPDHGKQLHPVAHTGLKKLSDREQLVQWIAQREDVWIQPKIDGVAVTLVYQHGKLESAVSRGNGLQGEDWTEKVRLIPEIPHLLTNVPSLLVLQGELFLKMTDHRQHIQGGVNARSVVAGEMRRHQPSPVLSQIGLFIWEWPDGPKTMPERLEKLTEMGFAMTADYTHAIGSFADAEKWHHYWYHNPLPFVTDGVVLRQTKEPQGRYWRNTSADWAIAWKYPPFHQVAEVIDVVFSVGRTGKLAVVLKLNLLKLDDKSVSRVNVGSLSRWKQWDVLPGDRVSVSLAGQGIPRLDNVVWRSTERLPIVSPSEHDFHAFSCFRYSTVCQQQFLARLVWLSGEHGLNLTGVRDGMWLRLMQHGLLEDVLSWLSLTEAQLNAVTGMGDKRARDIYKSLQSARQMPLSRWLLALGLPVPRSAISALNHVNWLALQQWTAQQWRQFSGIGERRAEEIMAFLKHPAVVEFIARLDAEGIHR
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.