PharMolix/UniProtQA huggingface dataset:
Protein: NUD14_BOVIN
Sequence: MERIEGVAVGRCAASPYLVPLTLHYRQNGAQKSWDFMKTHDSVTILMFNSSRRSLVLVKQFRPAVYAGEVERLFPGSLAAAEQDRPQALQAALPGSAGVTYELCAGLLDQPGLSLEEVACKEAWEECGYRLAPSDLRRVTSYKSGVGLTGSSQTMFYAEVTDAQRGSPGGGLAEEGELIEVVHLPLDGARTFADDPDVPKTLGVIFGISWFFSCVAPGLGLQ
What is the function of this protein?
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP.  The physiological substrate is probably UDP-glucose.  Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).
What are the official names of this protein?
Uridine diphosphate glucose pyrophosphatase NUDT14, UDPG pyrophosphatase, UGPPase, Nucleoside diphosphate-linked moiety X motif 14, Nudix motif 14.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_ACET2
Sequence: MANKQKIRIRLKAFDHQVLDQSAEKIVETAKRTGAKVSGPVPLPTEREVITILRAPHKYKDSREQFEMRTHKRLIDILLPTPKTVDALMRLDLPAGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ISCS_SHELP
Sequence: MKLPIYLDYAATTPVDPRVAEKMMQYMTMDGIFGNPASRSHRYGWQAEEAVDIARNQVAELINADPREIVFTSGATESDNLAIKGVAHFYHKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLEPESNGIIPIEKLEAAMREDTILLSLMHVNNEIGVIHDIDAIGELCRAKKVIFHVDAAQSAGKLPIDLQKSKVDLMSISAHKMYGPKGIGALYVRRKPRIRLEATMHGGGHERGMRSGTLATHQIVGMGEAAAIAKADMESDNARIRRLRDRLWDGIKHIEETYINGDAEQRYCGSLNVSFNFVEGESLMMALKDLAVSSGSACTSASLEPSYVLRALGLDDEMAHSSIRFSIGRFTTEEEIDHAIETITKSIGQLREMSPLWEMFKDGVDLSTVQWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16P2_ORYCO
Sequence: MDHEADAYRTDLMTITRYVLNEQSRNPEARGDLTILLSHIVLGCKFVASAVNKAGLAKLIGLAGETNVQGEEQKKLDVLSNEVFVKALVSSGRTCVLVSEEDEEATFVDPALRGKYCVCFDPLDGSSNIDCGVSIGTIFGIYMIKDKDNVTLEDVLQPGKNMVAAGYCMYGSSCTLVLSTGNGVNGFTLDPSLGEFILTHPDIKIPKKGKIYSVNEGNAKNWDEPTAKFVEKCKFPKDGSSPKSLRYIGSMVADVHRTLLYGGVFLYPADKKSPNGKLRVLYEVFPMSFLMEQAGGQSFTGKERALDLVPTKIHERSPIFLGSFEDVEEIKGLYAAQAKLEHNH
What are the official names of this protein?
Fructose-1,6-bisphosphatase, cytosolic, FBPase, D-fructose-1,6-bisphosphate 1-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHA15_MOUSE
Sequence: MKTKNRPPRRRTPMQDTEATPGEQTPDRPQSGSGGSELTKGLRSRTARASGGRGEVSRRRQGSGGRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAMLGVTEDQPQGHLQRYSTQIHSFREGS
What is the function of this protein?
Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated (PubMed:17612490).  Repression may occur through muscle-specific E-box occupancy by homodimers.  May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain.  Serves as a key regulator of acinar cell function, stability, and identity.  Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport.  May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages.  Binds to the E-box consensus sequence 5'-CANNTG-3'.
What are the official names of this protein?
Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: G6PD_LEUME
Sequence: MVSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALNDDEFKQLVRDSIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIEEAADKFDIDGNRIFYMSVAPRFFGTIAKYLKSEGLLADTGYNRLMIEKPFGTSYDTAAELQNDLENAFDDNQLFRIDHYLGKEMVQNIAALRFGNPIFDAAWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQNHTMQIVGWLAMEKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKPYLEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIVFKAGTFNFGSEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLGWTVSDEDKKNTPEPYERMIHDTMNGDGSNFADWNGVSIAWKFVDAISAVYTADKAPLETYKSGSMGPEASDKLLAANGDAWVFKG
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.  Can utilize either NADP(+) or NAD(+).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD, Glucose-6-phosphate dehydrogenase (NAD(P)(+)).
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: ILIC_NEOS2
Sequence: MITNDLIAQHSLTLTIASSVLLVFLLSRLLRKDATGKAQGCRPVAKRWQWDPILGLDIVLAQIGALKGNYYLPWLIELHSNMPKTFEINFFGKRQIYTSEPDNLKAMTATNFHDFGIEPMRRHTKGSMPFADKGISTVDGKEWEFSRFLLKPFFYREVYTSTDRIEPFADHMMALIPGDGESFNMQSLIQRWFLDLTTNFIFGKPMDALENPDRARITWAMLDVLKGGRLRAQFYMMMWAFNWTWWYKAVAEVHDFINVHIRETYKEIEEREQRIKDGKPVEPERTDLIWYMAWNLRDEELLRSQLCLVFVPNNDTTSIFISNCIWHLARHPEAWEKLRQEVLAHGDAPLTFEALRNMKYLQCVLNETHRLTPNNVTQIRVCLNDSVLPVGGGKNAKEPFFVRKGDVVSITKTVMYRDPEIWGNDAEEFKPERFDGRRVFWEFLPFGGGPRRCPAQMMVQTEAAYMLARLARVYRRIEARDPAPYTAVMRIGPSNKTGVQIAVYK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:31216742).  IliC catalyzes the ring expansion of the tetramate intermediate to the acyclic 2-pyridone intermediate that contains the trans bis-diene chain (PubMed:31216742).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:31216742) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase iliC, Ilicicolin H biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FOLD_CORA7
Sequence: MSATKLDGNLYRDEIFEDLAQRVAALKEKGITPGLATVLVGDDPGSHSYVKMKHRDCEKLGINSIRKDLPADVSQEELERVIEELNNDDACTGYIVQLPLPKHLDENRVLELIDPAKDADGLHPINLGKLVLNEEAPLPCTPNGCIHLLRRFGVELDGAKVVIIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETREADVIIAAAGKAHMLTADMVKEGAAVLDVGVSRVDGKLAGDVAEDVWEKAGYVSPNPGGVGPLTRAFLVSNIVERAEKLAAQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LCL2_FUSV7
Sequence: MRYLIAILSLLSLANAQFGGFFDQMFGQQGGHEQHHGQPQNNPSDASHYRHQYDNSVCDKYLCPDTLACVHFPHHCPCAWDAQQEKFELAEGQRMCVSRGGFREGETARKLELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: PNP_STRPQ
Sequence: MSKQTFTTTFAGKPLVVEVGQVAKQANGATVVRYGDSTVLTATVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFNGPIAGVQVGYIDGEFIINPDKEQMEASLLELTVAGSKEAINMVESGAKELSEDIMLEALLKGHQAIQELIAFQEQIVAVVGKEKAEVELLQVDADLQADIVAKYNAQLQKAVQVEEKKAREAATEAVKEMVKAEYEERYAEDENLATIMRDVAEILEQMEHAEVRRLITEDKIRPDGRKIDEIRPLDAVVDFLPKVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLAPEYKKRFLHHYNFPQYSVGETGRYGAAGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIAGITPQILEEALAQAKKARFEILDVIEATIAEPRPELAPTAPKIDTIKIDVDKIKVVIGKGGETIDKIIAETGVKIDIDDEGNVSIYSSDQAAIDRTKEIIAGLVREAKVGEVYHAKVIRIEKFGAFVNLFDKTDALVHISEIAWTRTANVSDVLEVGEDVDVKVIKIDEKGRVDASMKALIPRPPKQEKKEEKHD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_KLEP7
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEITGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDANGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HACL_ACTC0
Sequence: MADRQDAERSGAGPARQSVPVASLVAEFLQEHGVDRVFGLQGGHIQPIWDQLARRGVRIVDVRDEGSAVHMAHAHTELTGQTAVAMVTAGPGVTNTVTAVANASVSRIPLLVIGGCPPIPQSNMGPLQDIPHTAILEPITRLARTLRSADQVLREFDEAWARASGDRGEPGPVYLEIPTDVLRRDVPPALQMREHLRAKPKRRPQPHPDDVAAVADLIRAAEKPAIISGRGARTTDGTDLVRLLDASGAAYLDTQESRGLVPDSHPAAVGSARSAVMRDTDLLITVGRQLDYQLGMGSPAVFPHAKVVRIADTASELIDNRRGEVEILAEPGAALAAIADALKDHTPDTSWRDELKAKHRKRAEDYRQALHSTENGADGHIHPNRIFGALDALDGDVLDLGETIMIADGGDLLSFGRLGITKARRYLDAGAFGCLGVATPFAIGAALAYPDRPVVAVTGDGAFGITATEIDTAVRHDAKIVVIVSNNRAWNIERYDQAENYGLVVGTDLADSDYAGVARAFGAHGERVTDPAELEGAIRRALANAPALVDVVTTQDAASPDSGKGLGFVPDYQALTPWNDAEVARRQEGI
What is the function of this protein?
A lyase that reversibly degrades 2-hydroxyisobutyryl-CoA (2-HIB-CoA) to acetone and formyl-CoA (PubMed:34952003).  Probably also cleaves 2-hydroxy-2-methylbutyryl-CoA to butanone and formyl-CoA.  Does not act on 2-hydroxy-2-ethylbutyryl-CoA (Probable).  A C-terminal lid closes the active site upon substrate binding, and with residues Leu-127 and Ile-492 restricts the size of the active site cavity so it can only use short-chain (C4 and C5) acyl substrates (PubMed:34952003).  Part of a pathway that allows cells to grow on 2-methylpropane-1,2-diol or 2-hydroxyisobutyric acid (2-HIBA) as a sole carbon source (PubMed:32351493).
What are the official names of this protein?
2-hydroxyacyl-CoA lyase, AcHACL, HACL, 2-hydroxyisobutyryl-CoA lyase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: CDC27_RAT
Sequence: MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTALVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDNVPLGTGPSILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVPSTGAPTKKSVARMGHTGAKSVFSQSGNSREATPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Cell division cycle protein 27 homolog.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: RNPH_ACTSZ
Sequence: MRPNNRAINQPRPIKITRHYTKHAEGSVLVEFGDTKVLCTATVDESVPRFLKGQGQGWVTAEYGMLPRSTHSRMQREAAKGKQGGRTMEIQRLIARSLRAMVDLEALGERSVTLDCDVIQADGGTRTASITGACVALIDAVNGLVDNGTLTVSPLKGLVAAISVGIVDGTPVCDLEYVEDSAAETDMNVVMMEDGRMIEVQGTAEGEPFSHEELLTLLNLAKQGCKRIFEAQRAALAD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: LEU1_PSEPK
Sequence: MTMLKDPSKKYRAFPTIDLPDRTWPSKTITQAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATEMEFAKEVCDAVIEVWNPTPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPLLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLHKEYLQANAPYALVSHRLQEENGHSAVEVEVAGEGETTLHWRGKGNGALEALVAGLPIAVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: CRCB2_GEOKA
Sequence: MVYLAVGIAGMIGALVRYGLGLVVPAAAVGGFPLGTLFINWTGSFLLSWFTVMFTRRPAWPPWLKTAVTTGFVGSYTTFSTLSVECVELMEQGRFGMAAVYIAASLFGGLLASWAGYAAAQPERKEGIG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL22_VIBCM
Sequence: MEAIAKHNFARISPQKARLVADQIRGKSVDQALELLTFSNKKAAELVKKVLESAIANAEHNEGADIDDLRVAKIFVDEGPVMKRIMPRAKGRADRILKRSSHITVVVADR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: GLUA3_ORYSJ
Sequence: MATIKFPIVFSVVCLFLLCNGSLAQLLSQSTSQWQSSRRGSPRECRFDRLQAFEPIRTVRSQAGTTEFFDVSNELFQCTGVFVVRRVIEPRGLLLPHYSNGATLVYVIQGRGITGPTFPGCPETYQQQFQQSEQDQQLEGQSQSHKFRDEHQKIHRFQQGDVVALPAGVAHWCYNDGDAPIVAIYVTDIYNSANQLDPRHRDFFLAGNNKIGQQLYRYEARDNSKNVFGGFSVELLSEALGISSGVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQQQEQVQSRDYGQTQYQQKQLQGSCSNGLDETFCTMRVRQNIDNPNLADTYNPRAGRITYLNGQKFPILNLVQMSAVKVNLYQNALLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFDGELRRGQLLIIPQHHVVIKKAQREGCSYIALKTNPDSMVSHMAGKNSIFRALPDDVVANAYRISREEARRLKHNRGDELGVFTPSHAYKSYQDISVSA
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
Glutelin type-A 3.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
Protein: TRUB_FRAP2
Sequence: MKKNRLNLNGVVVINKTQGLSSNKVLQKLKYLFNAQKAGHTGTLDPMATGVLPICFGRATKIAQYLLDSDKEYIATIKLGIETDSGDAEGEIIAKNADIPELTVEYLETVLAKFRGDIVQIPPMYSALKHNGQPLYKLAREGKAIEVKPRNINIYELELLEFNTDSLKIRVKCSKGTYIRSLAIDIGKALGCGGHLIALQRTQSGPFRIETALDLDNLKDLSFEQKLASIASVESVFIDKPIYSLVEEEKDDLYKRGLFADKSHLDGTVRIYDDEKFVAIAEFDKGKLISKKFFDQDIFISE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y7254_BRADU
Sequence: MNERSPPRRPATFRLDDPGVVVTEADETARLGRGTIQITPEHDPATLPVPIEAVLPARRGLPWGALFWSGLAGLTLLGVGLGVVHLIEDLFARSESLGFVGLAFAFVTALALAVVIGREAYGLARLATIEKLHQRAAAVLASDDRKESRVIVQDLLKIAHQNPQLARARATLESHTGEIIDGADMIRLAERELMSPLDAEARRLVSSAAQKVSIVTAVSPRAAIDVMFVFVAALRLIRQLAYLYGGRPGALGMIRLLRHVIAHLAITGGMAASDSLVQQMLGHGIAAKLSQRLGEGVLNGLLTARLGLAAIEVTRPLPFAALPPPKLSDLATDLLRKKEDEEE
What are the official names of this protein?
UPF0283 membrane protein blr7254.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IGHM_HUMAN
Sequence: GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK
What is the function of this protein?
Constant region of immunoglobulin heavy chains.  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).  IgM antibodies play an important role in primary defense mechanisms.  They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions.  The membrane-bound form is found in the majority of normal B-cells alongside with IgD.  Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases.  It may cause death of cells by apoptosis.  It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer.  After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).
What are the official names of this protein?
Immunoglobulin heavy constant mu, Ig mu chain C region, Ig mu chain C region BOT, Ig mu chain C region GAL, Ig mu chain C region OU.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Protein: ORF14_BPKHP
Sequence: MLEKLNNINFNNISNNLNLGIEVGREIQNASWIKSPFFSITGTGADRGVRLFSVASQQPFRPRIKAQLSGSGVSGNTDFEANYDNLEILSQTIYPDAFGNSLRSKIKAYSELERIDFIKESVDSLTTWMNEERDKRIVASLTNDFTNYLYTQTMNVATIRKAIFHARNGLKGDNSKAFPIKPIRATMQSVGNVMVQNTSYIILLDSYQANQLKADSEFKELRKLYAFAGEDKGMLYSGLLGVIDNCPVIDAGVWNKFNVGMPNSSISDSDFMRYLNKANVSSIVTPRQFKEKLNQEKDEKKRSINKEISIGCLIGASAVLLAGSKETRFYIDETVDAGRKSLVGVDCLLGVSKARYQSTDGVVTPYDNQDYAVIGLVSDME
What are the official names of this protein?
Major structural protein ORF14.
Protein: RPOZ_BURMA
Sequence: MARITVEDCLKQIPNRFELALAATYRARQLAQGHTPKIESRDKPTVVALREIAAGQVGVEMLKKVPA
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: GLMU_HYPNA
Sequence: MTDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPSQDVLIAHLGKHHPDVAIAYQDPPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIEDLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIVEAREATPFQLRVRLCNSGVMAGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAEAEAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRAFSHLEGAVVGEGCSVGPYARLRPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGTIGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVAPVRIGDGAYIGSGSVITKDVPDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.