PharMolix/UniProtQA huggingface dataset:
Protein: PARC_STRP1
Sequence: MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISNGSFISDTISDQEVLVARTR
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit A, Topoisomerase IV subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TY3_ASCTR
Sequence: DPWDWV
What is the function of this protein?
Putative defense peptide.
What are the official names of this protein?
Tryptophyllin-3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Tryptophillin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPS_HELPY
Sequence: MKMYNIPTPTMAQVIMVDDPITTTEFVISALRDFFDKSLEEAKALTSSIHRDGEGVCGVYPYDIARHRAAWVRDKAKALEFPLKLLVEEIK
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: HSV2_CANGA
Sequence: MDVREAIQQEAGAETGFASVTFNQDESCFSCANEQGFLVYNTFPLSLKLTKEFKQTPERGAGIGYSQMLYRTNYIALVGGGQRPRYSLNRVVIWDDLQQKESFSLKFMSIVRKVVLSRVHLVVALENELFIYSFHSTPKLLCPPIKTAPFGPFDFKVVTIEGKATDQAKVTSLLAYPSAKLTGQLHVADLSKLRSNQNNNQDMALTSESFLPTTIIKAHKAPIRNVRINNQGTMVATASRKGTLIRIFSTHNGILLKEFRRGLDRAEIYDMCFSPLGTRLAVVSDKQTLHVFQIAPMAEGTLNPANPEDHQSSGSNGHIKANTNQVHSLRNIVPTSWKPKYLDSVWSMCKVHLRNPKLRNNVNDLAFNEDRCTIAWCRQNRSHTFKNGNHFNENEENKLVLVWKNSRIWEKYVILEKEAPNSNDGIKGPSPLTEWELVRESWREL
What is the function of this protein?
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
What are the official names of this protein?
SVP1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Protein: CAPD_RICCN
Sequence: MFVDKTLMITGGTGSFGNAVLSRFLKSGIINDIKEIRIFSRDEKKQEDMRIALNNPKLKFYIGDVRNYKSIDEAMHGVDYVFHAAALKQVPTCEFYPMEAINTNVLGAENVLSAAINNKVTKVIVLSTDKAVYPINAMGLSKALMEKLAIAKARMRSPGETVLCVTRYGNVMASRGSVIPLFINQIKQGKVLTITEPSMTRFLMSLVDSVDLVLYAFEHGHQGDIFVQKSPASTIEVLAKALQDIFDSKNEIRFIGTRHGEKHYESLVSSEEMAKADDLRDYYRIPMDGRDLNYAKYFVEGEKKVALLEDYTSHNTKRLNLEEVKELLLTLDYVQEELKNA
What is the function of this protein?
Epimerizes UDP-galactose to UDP-glucose.
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide synthase family.
Protein: RL20_MANSM
Sequence: MARVKRGVIARARHKKVLKAAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGLSYSKFINGLKKASVEIDRKILADIAVFDKVAFAALVEKAKSAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GALT1_STRPN
Sequence: MKTIIDNFVDRVIEYGMYNEIDKIYVKNRVLALIGEEGIDRISDENDLKQIKDYLVEIALKNGKIKDLIEEKECLGAELMNFIVPLPSRLNDIFWSSYDISPQEAVEEFYKLSKDSDYIKTSAIAKNIEFRASTKYGELEITINLSKPEKDPKTIAAEKLVKATNYPKCLLCMENEGYQGRINYPARSNHRIIRLKLGDEVWGFQYSPYSYFNEHAIFLNSQHVPMAITSKTFEQLLEIVDILPGYFAGSNSDLPISGGSILSHNHYQGGKHIFPMEKAKFESEFCFKDFEDVNAGIVKWPMSVIRLQSENKNRLLDLATKILNKWREYSDLEVDIIAMTEDVPHHTVTPIARKVDGRYELDIVLRDNHTTEQYPDGVFHPHQDVQHIKKENIGLIEVMGLAILPPRLKPELEEVGKYLLGEDNAIADYHLEWADQLKEKYPRINKEEVNSVVQHEAGQVFARVLEDAGVYKNTPSGHEAFMRFVKSVGIN
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase 1, Gal-1-P uridylyltransferase 1, UDP-glucose--hexose-1-phosphate uridylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y748_ARCFU
Sequence: MKVGIVLNPHAGGGFDDLKRRVVVRVLKKLDGEFVTADKVAELLGIEAERVKVKETNTRLDTVNLVKALDGNVDVIAVFGGDGTVSDAASAKPQTPLLCIGIGTTNVSPALCPPDFDRLEEVEMRGLVVKFGGEERVAFNDVVVGSTILSTVDGKRVQVDARRYMRGEKVIATPRKFRARVEVGERVVEGVFGNIFVAMTDRRFLGKGIAGGASLSAFLGFKGVVACVSEGIVVSTYTKEDLRRVEPIVTSTISFDDEVVKIDADEVVSCDGNPLGVGRAEVAIEDGVVRVLKPFKEEE
What are the official names of this protein?
Uncharacterized protein AF_0748.
Protein: PYRB_POLAQ
Sequence: MSSENNAGANLVNQFNAAGELTHLLTLEGLPKEQILHILDTAQQFVSVTDPSREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVINLDISTSSTAKGESLLDTIDNLVAMQADIFVVRHSVSRAPIEIANHVPTHVHVVNAGDGSHQHPTQGLLDMYTMRHFKQNFKGLKVAIVGDIVHSRVAKSNIHALTTLGCEDIRVIGPESLLPSDLDMLGVKVYHSMEEGLKDVDVVMTLRIQKERMEAGQVPEGDAFFNQYGLTPTRLALAKSDAIVMHPGPMNRGVEIDSVVADGPQSVILNQVTFGIAVRMAVMSIVAGN
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: COAD_TREDE
Sequence: MVKAVFAGSFDPPTFGHLNVIERAQKIFTEVHVVIAVNNNKNYLFSGEERKHMMEELTQKWDNVFVNTWNSLIVNYAEKIGANVLIRGVRNVSDFSYEFDLAVMNKGLNQKIETVFMVPDTKYFVLRSSSIKELASFGGNLSGMVPPIVEKALKEKIEEI
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLID_PROMI
Sequence: MAGISALGVGAKMPLGETLMQLEAAENKRLEPLDKQMKSYDAQITAYGKIRSQLDKLQKASEELKKFDKIVATKVDDEFDAFKVTTDGKASIGNYTVSVTELAHAQTLKSKAVSDIKDPIGETLGEGKTRTLVITQKGEKEPLKIELTDSQTSIIELRDAINKKEGNVSATIVKAQDGVNHLVLTSRKEGTDSQMEITVEGDSKL
What is the function of this protein?
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament.  Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
What are the official names of this protein?
Flagellar hook-associated protein 2, HAP2, Filament cap protein, Flagellar cap protein.
What is the protein family that this protein belongs to?
Belongs to the FliD family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: TACY_LISSE
Sequence: MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  L. seeligeri is non-pathogenic, perhaps in part because this protein is about 25% as toxic as listeriolysin O.  Mutating a single residue in the undecapeptide increases toxicity 2-fold (PubMed:11583846).  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation (By similarity).
What are the official names of this protein?
Seeligeriolysin, LSO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host membrane and forms pores formed by transmembrane beta-strands.
Protein: KDSB_ALIF1
Sequence: MSFTVIIPARYQSTRLPGKPLADICGKPMIQWVYEQASKAGADRVIIATDDSRIEAVVKGFGGDVCMTSPNHESGTERLAEVIEKCGISADEIVVNVQGDEPLIPPSIIQQVAQNLSDSVAPMATLAVTIDEEDDVFNPNAVKVVTDAEGYALYFSRASIPWDRDAFAQGETLTANPLLRHIGIYAYRAGFINTYINWQPSVLEKIECLEQLRVLWYGEKIHVAVAKEAPAAGVDTPEDLEKVRAILSK
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_ECOBW
Sequence: MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHE1_BACCE
Sequence: EEKVPYNVLKTKPVGIEKSVDEVGHISKVDETLSFQERLKGDFSQRPASITKKTAVKQVKESYSMADLNKMNDRELVETLGSIKWHQYTDL
What is the function of this protein?
This protein is a metalloprotease with gelatinolytic and collagenolytic activity and is a component of the non-hemolytic enterotoxin complex (NHE).
What are the official names of this protein?
Non-hemolytic enterotoxin 105 kDa component, Nhe.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR7_STRPQ
Sequence: MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVATHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKCWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: PURA_STRAW
Sequence: MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILTPECTPVIGNGVVVDPSVLFSELNGLNERGVDTSKLLISGNAHIITPYNVTVDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRIQDLYDESILTQKVEAALDGKNQLLTKVFNRRAIEAGQVVEELLTYADRLKPYVADTVLVLNKALDDDKVVLFEGGQGTLLDIDHGTYPFVTSSNPTAGGACTGSGVGPTKISRVIGILKAYTTRVGAGPFPTELLDEDGEALRRIGGERGVTTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWEQIPVCVAYEIDGKRVEELPYSQTDFHHAKPIYENLPGWSEDITKAKTFEDLPKNAQAYVRALEEMSGAPISAIGVGPGRDETIEINSFI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPA_SHEVD
Sequence: MSDSNTGTVKWFNEDKGFGFLTQDNGGADVFVHFRAIASEGFKTLDEGQKVTFEVEQGPKGLQASNVIAL
What are the official names of this protein?
Cold shock-like protein CspA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_XYLFT
Sequence: MRLSEFHLHTTKEIPADAELVSHRLMLRAGMIRKLASGLYTWSPLGLRVLRKVEAIVRDEMNRAGAVEMLLPTIQPRELWEESERWEKFGSQLLKIKDRKQAEYCYSPTAEEAVTDYVRQELTSYKQLPVNLYQIQTKFRDEIRPRFGVMRAREFVMKDAYSFHLNDADLVREYENMRATYTRIFTRLGLEFRAVQADSGAIGGDASQEFHVIADSGEDVLAFSTGSDYAANIEAAIAATPGPRLTANETLQKVSTPTQKRCEDVAALLDIPLQRVVKSIAVMTDSGFFLALLRGDHTLNDIKLSKLPGLANFRLANEVEIARHLGSEPGFLGPVCPGMPIRIIADCEVAVMADFVVGANEVGFHLVGVNWGRDLPEPEVVADIRNVIEGDRAVDGGKICIARGIEVGHVFQLGRKYAEAMKATVLDEYGKAVTMTMGCYGIGVSRIVAAAIEQNHDVAGIIWPAPIAPWQVAVCVINPKKDPVITAAAEMLLAELQSADVDTVLDDRGLRPGVMFADMELIGIPHRIVVSERGLAAGTYEYRARRTAMVENLDKTTLLTRIKA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB51_SCHPO
Sequence: MSVKYFEPEEIVEHNNSKDMYMVINGKVYDVSNFADDHPGGLDIMLDYAGQDATKAYQDIGHSIAADELLEEMYIGDLKPGTEERLKELKKPRSFDNDTPPLPLLIALIVLPAIAVIVFVKLNK
What is the function of this protein?
Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
What are the official names of this protein?
Probable cytochrome b5 1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: SECA_PELUB
Sequence: MLNPLNFITKFIKSSNQKELDRINKIVVKVNSLEASVKNLSDEDFPKKTTELKDKLKNGENLDTLLPEAFALVREASKRTRNERHHDVQILGGVVLHEGKIAEMRTGEGKTLTISLAAYLNALTEEGVHIVTVNDYLAKRDSQEMGEIYKFLGLTFGFINNDQDDLERKKNYNFDITYATNSELGFDYLRDNMKFSKEQMVQRGHVYTIVDEIDSCLIDEARTPLVISGAAEDKTEQYLAIDKLIKRLLPEHYEIDEKDRNILLTNEGINNVEKIFSDAGILKNNNFYDPENLSLVHHVNQSLRAHHLFEKGKDYIVKDGTLKIIDELTGRILEGRRFGDGLHQALEAKERIDVQAENQTLASITYQNYFKLYNKISGCTGTAATESQEFYEIYNLVVVIIPTNKEMIRKDWNDQIFRTEEEKNKAIIEKVLECHKQGQPILVFTSSINKSEIYSKLLNDEKIKHVVLNAKNHENEAEIIANAGKMNSVIITTSISGRGVDIQLGGKKGSQPDDELLENKNKIKSLGGLFVIGTERMESRRVDNQARGRAGRQGDEGSSIFYVSLEDDLMRIFGSESMNNILQKLGLKDGESIDHPWINKALERAQQKVEARNFDIRKNLLKFDDVLNDQRHVIFSQRNGVMNSEKVFDYSDEFLSEIISHLISLKTQKLSTTKNNEFNNQLKTLLGKSVDDNEFKNVTELKDEEFKNKINSKFLEARNERIKMLDEEKAKEVEKRIFLQCIDLNWKSHIQYLEQLRQVIGLRSYGQRDPLVEYKKEAFFLFENLLNKLKMDFVTILINLKIVQEPSESISRPLKKETSNDPNCLLIKRKNEKISRNEKCEATGKKFKNCCGAL
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: DHSD_PORPU
Sequence: MYKTLLAQVFFHSIAKKKLYFFWLPRLFSLLLVPGFLFDIEILFLFHPIILLHASLGLSVIIEDYIHIETIKFQYLSLIKLLLVLLINLNILYLL
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase membrane anchor subunit, Succinate dehydrogenase, subunit IV.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: REX_CALS8
Sequence: MFKKKNVSLAVVRRLPRYLRYVEDLLNHDIMRISSSELSQRMGYTASQVRQDFNNFGGFGQQGYGYSTQVLYENLVKILGLDKNFKMIIVGVGNLGQALANYANFYKKGFRLVGLFDVDPQKVGKSIRNIKIQHIDELKDFIKKNDVDIGVLCVPSEVAQEVANLMVEGGIKGIWNFTAKEIEVKDDVVVENVHLIDSLMVLSYKLNEKLLEKQEASQK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_BPF2
Sequence: ASNFTQFVLVNDGGTGNVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNLELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY
What is the function of this protein?
Acts as a translational repressor of viral replicase synthesis late in infection.  This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the Levivirus capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=The shell is composed of 178 copies of the capsid protein and 1 copy of the maturation protein.
Protein: CF410_MOUSE
Sequence: MKLTRKMVLSRAKASELHNVRKLNCWGSQLTDISICREMPSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNELFYLKDLPHLRVLWLAENPCCGTSPHLYRMTVLRNLPHLQKLDNQAVTEEELTRALMEGDEITAAPHREGAGNGCPKPPYALNSVSSATETSQHLLSYTEETEVQGQTTTDQSPSFSPRDTMRSHKNRNILTAILLLLRELDTEGLETVQQTVGSRLQALHRPEPQEDME
What is the function of this protein?
Plays a role in cilia formation and/or maintenance (PubMed:21289087).  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Involved in DNA damage repair (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 410.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Mitochondrion. Cell projection, cilium, photoreceptor outer segment. Cytoplasm. Note=Localized to the connecting cilium of the cone and rod photoreceptors (PubMed:27548899, PubMed:26974433). Colocalizes with NEK1 and SPATA7 at the basal body (By similarity).
Protein: GNPI2_MOUSE
Sequence: MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAMEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLYSMKEGN
What is the function of this protein?
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.  Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P.  At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis.  Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.
What are the official names of this protein?
Glucosamine-6-phosphate isomerase 2, Glucosamine-6-phosphate deaminase 2, GNPDA 2, GlcN6P deaminase 2.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIGIT_MOUSE
Sequence: MHGWLLLVWVQGLIQAAFLATAIGATAGTIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSDDRNGLAQFQTAPLGGTMAAVLGLICLMVTGVTVLARKDKSIRMHSIESGLGRTEAEPQEWNLRSLSSPGSPVQTQTAPAGPCGEQAEDDYADPQEYFNVLSYRSLESFIAVSKTG
What is the function of this protein?
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
What are the official names of this protein?
T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: COX7B_RAT
Sequence: MLPLAKNALSRLQVRSIQQVVARQSHQKKTPTFHDKYGNAVLAGGSIFCISAWTYTATQIGIEWNLSPVGRVTPKEWRDQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity).  Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).
What are the official names of this protein?
Cytochrome c oxidase subunit 7B, mitochondrial, Cytochrome c oxidase polypeptide VIIb.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIb family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.