PharMolix/UniProtQA huggingface dataset:
Protein: PTN23_RAT
Sequence: LNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMLAKIEDKNEVLDQFMDSMQLDPDTVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELQEQKLQETLGQAGAGPGPSVTKAELGEVRREWAKYTEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDNVLRALTEANVQYAAVRRVLSELDQKWNSTLQTLVASYEAYEDLMKKSQEGKDFYADLESKVAALLERAQSLCRAQEAARQQLLDRELKKKAPPPRPTAPKPLLSRREEGEAAEAGDQPEELRSLPPDMMAGPRLPDPFLGTAAPLHFSPGPFPGSTGPATHYLSGPLPPGTYSGPTQLMQPRAAVPMAPGPVLYPAPVYTSELGLVPRSSPQHGIVSSPYAGVGPPQPIVGLPSAPPPQFSGPELAMDVRPATTTVDSVQAPISSHMALRPGPAPAPPQPCFPVPQPVPQSVPQPQPLPTPYTYSIGTKQHLTGPLPQHHFPPGIPTSFPAPRIGPQPPPQLQPQPQPQPQPQPPPQPQPQPQPQPQPQPQPQPQRPVFGPQPTQQPLPFQHPHLFPSQAPGILTPPPPYPFTPQPGVLGQPPPTRHTQLYPGPPPDTLPPHSGALPFPSPGPPHPHPTLAYGPAPSPRPLGPQATPVSIRGPPPANQPAPSPHLVPSPAPSPGPGPVPSRPPTAEPPPCLRRGAAAADLLSSSPESQHGGTQPPGGGQPLLQPTKVDAAERPTAQALRLIEQDPYEHPERLQKLQQELESFRGQLGDAGALDAVWRELQEAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQRPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPIERGQPMVHGALSVALSSVRTTDTHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPGNLLRFIQEVHAHYLHQRPLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGSRIPELPQLVRRMRQQRKHMLQEKLHLKFCHEALVRHVEQVLQRHGVPPPGKPVASMSVSQKSHLPQDSQDLVLGGDVPISSIQATIAKLSIRPLGGLDSPAASLPSLVEPPGLPPASLPEPTPAPPSSPPPPSSPLPEPPQPEEEPSVPEAPSLGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKQNFLQAHNGQGLRAAQPTDDPLSLLDPLWTLNKT
What is the function of this protein?
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes.  May act as a negative regulator of Ras-mediated mitogenic activity.  Plays a role in ciliogenesis (By similarity).
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, HD-PTP, Protein tyrosine phosphatase TD14, PTP-TD14.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body.
Protein: GUAA_PSYIN
Sequence: MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGPESVTAEGSPRAPEYVFTAGVPVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGASELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIANTATCQFAAIANEEKRFYGVQFHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVDSSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMAGESDPEAKRKIIGRVFVEIFDEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETIDFMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: LOLB_HAEI8
Sequence: MNNMKTFKFLTALFATAILTACTLDMERPTNVQYIDKTDAIWQQHLQKIQKIQSYQAKGQIGYISPTERFSSRFEWQYQNPKSYTLKLYSLISKSTLLIQMHQSGMTISDNNDNQQSAANAKLLLQEIIGMDVPLEHLAYWLKGQPAMNADYQVGTNHLLGAFTYHVDGSQWTADYLTYHSNNSMPENILLKNDSTKQTLKIRVDEWIY
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RENR_RAT
Sequence: MAVLVVLLSSLVSSALANEFSILRSPGSVVFRNGNWPIPGDRIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATIMVTVKGVDKLALPTGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLNSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDELGKRYGEDSEQFRDASRILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLVRKSRTILETKQENTQSPYNLAYKYNLEYSVVFNLVLWIMTGLALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD
What is the function of this protein?
Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity).  May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity).  By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity).  Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
What are the official names of this protein?
Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, Renin/prorenin receptor.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane; Single-pass type I membrane protein. Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Cell projection, axon. Endosome membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.
Protein: SZRD1_MOUSE
Sequence: MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPTGPPPQIRILKRPTSNGVVSSPNSTSRPALPVKSLAQREAEYAEARRRILGSASPEEEQEKPILDRPTRISQPEDSRQPSNVIRQPLGPDGSQGFKQRR
What are the official names of this protein?
SUZ domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SZRD1 family.
Protein: MURG_YERPG
Sequence: MSGKTKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEASLVPQHGIEIDFIKISGLRGKGLMAQLTAPIRIYRAVRQAQKIMRDYQPNVVLGMGGYVSGPGGLAAWLCGVPVVLHEQNGIAGLTNRWLARIAKKVLQAFPGAFPNADVVGNPVRTDVLALPLPAVRLSGREGPIRVLVIGGSQGARILNQTLPLVAASLGEQITLWHQVGKGALPEVSQAYQQAGQAGHLVVEFIDDMAAAYAWADVVVCRSGALTVSEVAAAGLPAIFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQFTATSVSSLLASWDRATLLSMAERARSVAIPDATERVAAEVVAASKSA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CCD47_RAT
Sequence: MKAFCAFCVVLLVFGSVSEAKFDDFEDEEDIVEYDDNDFAEFEDVVEDSVTESPQRVINTEDDEDEATVELEGQDEGQEGDFEDADTQEGDTESEPYDDEEFEGYEDKPDTSSNKNKDPITIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDMDTYVFAVGTRKALLRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMEALLPLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMKMKQIKVKAM
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity).  Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein.  Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity).  Involved in the regulation of calcium ion homeostasis in the ER.  Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity).  Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).
What are the official names of this protein?
PAT complex subunit CCDC47, Coiled-coil domain-containing protein 47.
What is the protein family that this protein belongs to?
Belongs to the CCDC47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane.
Protein: CALMS_CHICK
Sequence: MAERLSEEQIAEFKEAFSLFDRDGDGCITTMELGTVMRSLGQNPTEAELQDMVGEVDADGSGTIDFPEFLSLMARKMRDSDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIKEADCNNDGQVNYEEFVRMMTEK
What are the official names of this protein?
Calmodulin, striated muscle.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: YJGB_BACSU
Sequence: MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTNQSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHWNMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTDEIDYVYDTGRYELHFVIGTDQTADHVNLKAK
What are the official names of this protein?
Uncharacterized protein YjgB.
Protein: RLR6_PLAVT
Sequence: MRGAFYIAIALLVVRSRTATEIDPTDISEPYLNVVAIGGEDTRTTPKRYLRDGLAHSAANEERVKANVLSKSAKTLAAETEDWLRLSLSIGGHSHTPKSKRKVNLSPAKSQSGIRKKSTSINKRNYDKQVQADDPRLPEYLQIHQTFLKIPGMPHKMSLTEAVVMYGMVNRKVASKPGTKKNNEPLLRLMERSKWEDFENALDPMFMRLAPHEEMRKEYFHRLHTMYAKVYTFCHAHPSACTNKRAVSPLEKMIKVQKTKALLPLFKS
What is the function of this protein?
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 6.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm.
Protein: BTB6A_DANRE
Sequence: MPAAPECRLSNHGRIMKCVTFLLLLPETLKKLKRASKHPGRLSVCYNILTLSLKKRMAAELYPVSDHATLQKSGAVMLSLPEKKRNVEPVSQTTASIATTPTTEQNINNNNVEIPSWHSAHPTLRERNALMFNNEQMADVHFIVGPPGESQRVPAHKYVLAVGSSVFCAMFYGDLAEGDSDIHIPDVEPAAFLILLKYMYSDEIELAPDTVLATLYAAKKYLVSALARACVGFLETSLEARNACVLLSQSRLFEEPELTQRCWEVIDAQAELALRSEGFSEIDLPTLESILHRETLNVKESVVFQAVLGWADAECRRQGLSPTSQNQRSVLGKALHLVRLPSMTLQEFADGAAQVDILTLEETHSIFLWYTAATKPSLGFPVNAREGLTAQRCHRFQSSAYRSNQWRYRGRCDSIQFAVDKRVFIAGLGLYGSSGGKAEYSVRIELKRQGVLLAQNLTKFVSDGSSSTFPVWFEHPVQVEQDAFYTVSAVLDGSELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQIPELIFYA
What is the function of this protein?
Adapter protein for the cul3 E3 ubiquitin-protein ligase complex.  Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation.  Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis.
What are the official names of this protein?
BTB/POZ domain-containing protein 6-A.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present mainly, but not excusively in the cytoplasm.
Protein: FL1L_ARATH
Sequence: MDVYFFVMEITSFLKLLSQTDGFGFGIFVIGCSSQFFNLVFLCCLLLLGLKFLSFKGTSLFLQYLEKINRISPNIEFFNSFNREHKDCNNNNNNNNNNNGFISKSHLADGLDQKKPIILHWSSDSTNRLSWENCDLLLLRDGLDHIQNRENTVALSETELDEKNHHGEEEESEDEEESQSQNDEDQLLDVITLRTMVKRERKRGDYMKKELEKERRAAESAAEEAMAMLLKLRMEKSVVEMETKQYKRVAEQKQVYDQEVIQSLQWMLMKLDDDEDKIQM
What are the official names of this protein?
Protein FLOURY 1-like.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y666_METKA
Sequence: MLRRDAWRQARFVHPRSYREKILRSLFFALTARINQMRRLDPEEYPEDPIEGYDRFLEIVREYAEDPDYDSPLLLLYESLSAAYAIFLRGEPVHPPGTEFPGVGKVRRTDDCYYCPIKERREDQPGSFCTLCPAEQDPEVVS
What are the official names of this protein?
UPF0305 protein MK0666.
What is the protein family that this protein belongs to?
Belongs to the UPF0305 family.
Protein: IF2B_PYRAE
Sequence: MDSEYAALLERAYKLVAPKAQRRAEIPKIEVENMPRKTIIPNFGQIAKRLNRDVYFMAKFFQKELAVPGTLEGDVFTLHGEKSPKVVEAVYDRFIRYYVVCPVCNSIDTELRKEGRIFIMRCLACGASTPVRPL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: PUB19_ARATH
Sequence: MIHTPTGSSRRILTFPAVNPCESISLTTLVDSLLQLAGEILSFKPKHFSTNKRSVKETLRHVQTLVIFFEELRIQIRVGSIPAGRSVILSLSELHVIFQKLKFLLDDCTRDGAKLYMLMNSGQVSAHFRDLTRSISTSLDTFPVRSVDLPGEVNELIYLVMRQTRKSEARPDRDDKRAIDSVYWFFNLFENRINPNSDEILRVLDHIGVRKWRDCVKEIDFLREEISVGKKSNIEIELLSNLMGFICYCRCVILRGIDVDDEEKDKEEDDLMMVRSLNVDDLRCPISLEIMSDPVVLESGHTYDRSSITKWFASGNITCPKTGKTLVSTVLVDNFSVKQVIQSYSKQNGVVMGQKGKKKVDVAESLAAEEAGKLTAEFLAGELIKGDEEEMVKALVEIRILTKTSTFYRSCLVEAGVVESLMKILRSDDPRIQENAMAGIMNLSKDIAGKTRIVGEDGGGLRLIVEVLNDGARRESRQYAAAALFYLSSLGDYSRLIGEISDAIPGLVRIVKSCDYGDSAKRNALIAIRSLLMNQPDNHWRILAAGIVPVLLDLVKSEEISDGVTADSMAILAKMAEYPDGMISVLRRGGLKLAVKILGSSEVSPATKQHCVALLLNLCHNGGSDVVGSLAKNPSIMGSLYTASSNGELGGGKKASALIKMIHEFQERKTGPGEPVLERERFVHAW
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 19, Plant U-box protein 19, RING-type E3 ubiquitin transferase PUB19.
Protein: MOAC_HAEIG
Sequence: MTTFTHINSQGEANMVDVSAKAETVREARAEAIVTMSKETLSMIVEGKHHKGDVFATARIAGIQAAKRTWELIPLCHPLLLSKVEVNLEPLLETNQVRIQSLCKLTGKTGVEMEALTAASVAALTIYDMCKAVQKDIVIEYVRLLEKSGGKSGHFIAEEK
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: HSPQ_YERPY
Sequence: MIASKFGIGQQVRHSLHGYLGVVIDIDPEYSLAPPEPDEVANNKTLRSSPWYHVVIEDDDGQPVHTYLAEAQLTYEDVDAHPEQPSLDELAASIRHQLQAPHLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP1_PARUW
Sequence: MATSNQLTPGMTLSINNKLYRVESSVKVTVPKGTPFIKAKLKDLSNNEMVEKSFKLNQPIKDVSLIERRLEFLYPEGDEYLFLDVVNLDQVLVPAEIVSGKVNYLKEGVEIKAFFYGETIFAVELPQFLELMVAKTHSDDENDLANGAKIAILETGAKIEVPPFIETGDIIKVDTKTDEYIQRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P 1, EF-P 1.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA4B_ORYSJ
Sequence: MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSALGVLAADGVVLVGEKKVTSKLLQTSRSAEKMYKIDSHLACAVAGIMSDANILLNTARLHAQRYALSYQEPIPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKHHGFQLYMSDPSGNYSGWKAAAVGANSQAAQSMLKQDYRDGLTREEAVALALKVLSKTMDSTSLTAEKLELAEVFLQPGTGEVQYQVCSPEAMGKLLAKAGLSQPAPEA
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-4-2, 20S proteasome alpha subunit C, 20S proteasome subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HEMH_PSEFS
Sequence: MTDHALLLVNLGSPASTSVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSRRLQQQMTAQWTQGPVELAMRYGEPSIESVLTRLATQGIRNVTLAPLYPQFADSTVTTVIEEAKRVVRDKKLDVQFSILQPFYDQPEYLDALVASARPYVEQDYDHLLLSFHGLPERHLTKLDPTGQHCFKDADCCKNASAEVLKTCYRAQCFSVARDFAERMGLPEGKWSVAFQSRLGRAKWIEPYTEARLEALAQQGVKKLLVMCPAFVADCIETLEEIGDRGLEQFREAGGEELVLVPCLNDDPQWAKALNTLCERAPTAL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMPA_BACSU
Sequence: MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS
What is the function of this protein?
Ensures proper spore envelope assembly (PubMed:22463703, PubMed:26387458).  Represses premature cortex assembly until coat assembly successfully initiates (PubMed:22463703).  Also participates in a quality-control pathway that selectively removes defective sporulating cells through regulated cell death.  Acts as an adaptator that delivers SpoIVA to the ClpXP proteolytic machinery for degradation, specifically in cells that improperly assemble the spore envelope (PubMed:26387458).
What are the official names of this protein?
Cortex morphogenetic protein A.
What are the subcellular locations of this protein?
Forespore. Note=Localizes to the surface of the forespore early during sporulation, while coat assembly is initiating (PubMed:22463703). Localization is dependent on SpoIVA (PubMed:26387458). Proper localization may also depend directly or indirectly on the presence of SpoVM (PubMed:22463703).
Protein: IF2_ERYLH
Sequence: MSDDNDKPRTRKPLGLKRSVDAGEVKQTFSHGRTNKVAVEVKRKRKLLKPGETPAPAPEPAPEPAPAPAPAPAAKKPAPKKPAPAAETPQERVARLQREAEEERLKLAEDARKRDDQKAKQNADDEKKRQEENKKAEEEAEKQAAAEAEAAAAAEAAPEEDADDGRKAPVARKFTPVARPEPKRPEKKKEEKKPARGGAKDKRRSGKLTVSKALNEDEGRRAMSLAKLKRAREKERRLKGGGSSAPREKQVRDVIVPEAITVGELAKRMGEKGADLVKELFNLDMMVTVNQTIDQDTAELLVEQFGHNIQKVSEADVDIQAEEDVDPEETLQPRPPVVTIMGHVDHGKTSLLDALRGTNVTKGEAGGITQHIGSYQVNTKSGGKVTFLDTPGHAAFSEMRQRGANVTDIVVLVVAADDGVMPQTIEAIKHTKAAGVPMIVAINKCDKPEADPDNIRNRLLEHEIIVEKLSGDVQDVEISATKKTGLDELLEKIELQAELLELKARPDRMAEATVIEAQLDKGRGPVATVLITRGTLKRGDTFVVGTESGRVRAVVNDQGKQIKEAGPSMPVEVLGLGGVPGAGDQLTVVENEQRAREVAEYRQEKATEKRTALAPTSFDTMFNNLQSNVIEWPVLVKADVQGSVEAIVTALHNISNDEIKVRVLHAGVGAITESDVTLAAASNAPIIGFNVRPNAKARELVKRDDVRMMYYDVIYHLTDEVAKEMAGELGPERIETVVGRADVKEVFKSGKKDKAAGLLVTDGVIRKGLFARLTRDDVIVSATTIASLRRFKDDVDEVRSGLECGVVLEDTNDIQPGDSLEVFEVEERERTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y461_NEIM0
Sequence: MTFLQRLQGLADNKICAFAWFVVRRFDEERVPQAAASMTFTTLLALVPVLTVMVAVASIFPVFDRWSDSFVSFVNQTIVPQGADMVFDYINAFREQANRLTAIGSVMLVVTSLMLIRTIDNTFNRIWRVNSQRPWMMQFLVYWALLTFGPLSLGVGISFMVGSVQDAALASGAPQWSGALRTAATLTFMTLLLWGLYRFVPNRFVPARQAFVGALATAFCLETARSLFTWYMGNFDGYRSIYGAFAAVPFFLLWLNLLWTLVLGGAVLTSSLSYWQGEAFRRGFDSRGRFDDVLKILLLLDAAQKEGKALPVQEFRRHINMGYDELGELLEKLARHGYIYSGRQGWVLKTGADSIELNELFKLFVYRPLPVERDHVNQAVDAVMMPCLQTLNMTLAEFDAQAKKQQQS
What are the official names of this protein?
UPF0761 membrane protein NMCC_0461.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPB_PSEU2
Sequence: MAATLGFRDLGLIDYETAWHAMKRFTDERGREAADEVWLVQHPPVFTQGQSGKAEHLLLPGNIPVVQVDRGGQVTYHGPGQLVAYLMLDVRRLGFGVRDLVTRIENTLIALLADYGVKAAAKADAPGVYVDGAKIASLGLRIRNGCSFHGLALNVDMDLEPFRRINPCGYAGLAMTQLSDQAGQIEFSEVSARLRAQLVKHLDYAEQATLTGGINHYD
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VHL_MOUSE
Sequence: MPRKAASPEEAAGEPGPEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDYPSVRKDIQRLSQEHLESQHLEEEP
What is the function of this protein?
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex.  Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions.  Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.  Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
What are the official names of this protein?
von Hippel-Lindau disease tumor suppressor, pVHL.
What is the protein family that this protein belongs to?
Belongs to the VHL family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Colocalizes with ADRB2 at the cell membrane.
Protein: DIUH1_HYLLI
Sequence: RMPSLSIDLPMSVLRQKLSLEKERKVQALRAAANRNFLNDI
What is the function of this protein?
Regulation of fluid secretion.  May stimulate primary urine secretion by Malpighian tubules and causes a dose-dependent stimulation of cAMP levels in the tubules.
What are the official names of this protein?
Diuretic hormone 1, DH-1, DH(41), Diuretic peptide 1, DP-1.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: CARA_AQUAE
Sequence: MRKTAILALEDGSYFVGYSFGAEGETGGELVFNTSMTGYQEILTDPSYKGQIVVMTYTQIGNYGVNDEDIESKSVQVNGFVVKEAFFRYSNWRAKKSLDEYLKENNVVGIYGIDTRALVKKIREKGSMKGVISTVEKDPKKLVQKARELPDISEQNLVEEVSAKDIYYWNQGDYDPRRGFLYRENEKPLVAVIDFGVKFNILRRLVSEGAKVVVVPPENAKEAIEKINPDAIFLSNGPGDPERVISGIRLTREYMEKKPIMGICLGCQIIGLALGGKTYKLKFGHHGGNHPVKDLRTGKIEITAQNHNFAIDPESLPEDVEVTHLNLLDNTVEGIKHKHLPIFAVQYHPENSPGPHDSYYLFKEFVKMAQG
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.