PharMolix/UniProtQA huggingface dataset:
Protein: SEC6_YEAST
Sequence: MSSDPLQQVCDLIKGDLSLERVRDIKEQLLKEKSVVEYQLNKESDKYYGEVEESLKLLNLSKNSVTSIKQQINEVNKLGNDNRFAINRYDILFRATKLYETVNTTSSIYDRIYNFVALMEHIERLLVAELAEDALETGCPHLLEIHFLLTSARDFQEQVVVMAKEATEDAQRTVMKLFSRLSGIISKFDKLLDGLTYDIVEMARAEQISLAIRLFKIYDLEEREDLRIEAIRNIIKKKEIEIEKSSIKKLPNSKNTARLQDETPKVIEYPTNKGLYQEIMSGTISTRTAPRGYKHFLINGINNSISEMFGEMREKYVGDQKFDVLDNMDWIFNELIIVKEHIANCCPPHWNIFEVYFDQYYKELHSLITDLVESEPETIIILDILAFDKTFQDTLKQDFGFTKSEVKSVIGDKEKETLFKDYLNLIVVKMTEWIGNLEKAEFDVFLERSTPPHSDSDGLLFLDGTKTCFQMFTQQVEVAAGTNQAKILVGVVERFSDLLTKRQKNWISKISEEIKKQINYNHKYDIDPESITPEDECPGGLVEYLIAVSNDQMKAADYAVAISSKYGKLVSKVYEKQITNHLEGTLDGFAEVAQCSSLGLITLMFDDLRKPYQEIFSKTWYMGSQAQQIADTLDEYLLDIKPQMNSVLFVNFIDNVIGETIIKFLTALSFEHSFKNKNNKFLEAMKRDFEIFYQLFVKVLDGNESKDTLITQNFTVMEFFMDLSCEPIDSILDIWQKYLEVYWDSRIDLLVGILKCRKDVSSSERKKIVQQATEMLHEYRRNMEANGVDREPTLMRRFVLEFEKQ
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component SEC6.
What is the protein family that this protein belongs to?
Belongs to the SEC6 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BRUC2
Sequence: MSISFDLTIDDTRDQLARHARASLEAKPSLIGMSREEMAAALIAAGVPERQVKMRISQLWHWLYVRGVSDFADMRNISKDLRAMLAQHFTIARPEVVEEQISQDGTRKWLFRFPPRGAGRPVEIESVYIPEEGRGTLCISSQVGCTLTCSFCHTGTQKLVRNLTSEEILAQLLTARDRLGDFPDKDTPDGAMVPAEGRKITNIVMMGMGEPLYNFEEVKKALLIASDGDGLSLSKRRITLSTSGVVPEIYRTGDEIGVMLAISLHAVRDELRDILVPINKKYPLAELIKACREYPGLSNAKRITFEYVMLKDINDSLDDAKLLVKLLQGIPAKINLIPFNPWPGTNYQCSDWEQIEKFADYVNAAGYASPIRTPRGRDILAACGQLKSESERLRKSERLALEAMMIAGHGE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_COXBU
Sequence: MFRGLNPIAVDAKGRIAIPARYREPIESEADGILVVTIDTEERCLLIYTHPQWEQIEQKLENLPSYHPASRRIQRLLIGHATEVELDRSGRILIPPVLREYAGLGSMVMLVGQGKKFELWGKSQWETAREDWLAEELPKGDDLPPELRSLSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DHB2_MOUSE
Sequence: MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids.  Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione.  Also has 20-alpha-HSD activity.
What are the official names of this protein?
Estradiol 17-beta-dehydrogenase 2, 17-beta-hydroxysteroid dehydrogenase type 2, 17-beta-HSD 2, Testosterone 17-beta-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RUVC_SHESA
Sequence: MAIILGVDPGSRITGYGVIQCLGRQQLYLGSGCIRTSGEDLPLRLKQIFDGISEIIRQYQPDEFAIERVFLAKNADSALKLGQARGAAIVAATVANLPVAEYSATQIKNAVVGTGRAKKEQVQHMIQQLLKLPAAPQADAADALGVAVCHYHTNQSLVALSGRATTRTYGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: NFUA_YERP3
Sequence: MITITDAAQSHFAKLLANQEEGTQIRVFVINPGTPTAECGVSYCPPDAVEATDTELKFEQLSAYVDELSVPYLQDAEIDFVTDQLGSQLTLKAPNAKMRKVDDSAPLMERVEYVLQSQINPQLAGHGGRVTLMEITPEGLAILQFGGGCNGCSMVDVTLKEGIEKELLQKFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: AGTR2_SHEEP
Sequence: MKANFSLATISKNITSSLHVGFVNISSNESTFNCSHKPSDKHLDAIPVLYYIIFGVGFLVNTIVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSHRYDWIFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCINPFLYCFVGNRFQQKLRRVFRVPITWLQGKRENGSCGKSSSFREMETFVS
What is the function of this protein?
Receptor for angiotensin II, a vasoconstricting peptide.  Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways.  Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
What are the official names of this protein?
Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TUSA_AERHH
Sequence: MMSALFCDATHELDAIGLRCPEPVMMVRKKVRLMADGETLLVSADDPSTTRDIPSFCRFMDHTLVASETEQAPYRYLIRKGQ
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4C_BOVIN
Sequence: MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
What is the function of this protein?
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration.  The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.  The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair.  Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.  In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RS11_STAAR
Sequence: MARKQVSRKRRVKKNIENGVAHIRSTFNNTIVTITDEFGNALSWSSAGALGFKGSKKSTPFAAQMASETASKSAMEHGLKTVEVTVKGPGPGRESAIRALQSAGLEVTAIRDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: DNAJ_LACDA
Sequence: MAANRDYYDVLGVSRDASDAEISKAYRKLAKKYHPDLNHEAGAEEKYKEVNEAYEVLHDPQKRQQYDQFGQAGMNGQGGFGGQYGGQGFGGADFGDFGDIFSSFFGGARQQVDPTAPQRGADLDYTMTIDFMDAIKGKTSEISYSRSTTCEVCKGSGAEKGTHPITCDKCGGSGMMTITQRSVLGMIQRQTTCDKCTGSGVIIQHPCHNCHGKGVKTQKQTLQVKVPAGIDNGQQIRLAGQGEAGKNGGPYGDLYIVFRVRPSKDFTRRGQTIYTTVPISFAQATLGDEINVKTVYGDTKLKIPAGTQPNQKFTLKEKGVPSLRGGSTGDQVTTVEIVIPKSINEAQRKALLEFVKASGGSIAPQEKGFFERLKEKLS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXE_ECOSM
Sequence: MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMCVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAGKYLIDERMKKRRTEAAAERALPNGETGNV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: REPEB_BPT4
Sequence: MVIFQLEYPLHHLVLFEVDADQPHEHEHDLILMGPFYLQQHRQTN
What is the function of this protein?
Involved in T4 DNA replication.  Important for the priming of leading strand DNA synthesis at oriE.  Binds to ssDNA.
What are the official names of this protein?
DNA replication protein repEB.
Protein: AGO3_ORYSJ
Sequence: MAGRGGRDPRRGYDGGYGYPRGGGGQGGTNRGRDGQRGGGRNGPRGGRFPGGRGVEPRRGGDVLGGGQGGGRGTTAGAGGLVRGGSELAVGAELRRRVPTCHVNDFPELGIGGTPVLVRRWRPRDHRDQHDHQSQRHHHRHHHHQRQRHHHHHQRQQRRGSRTRDPRVRRGPLRIPYGEDEKEEPPATPIASSNKNKREEPPTKHRPMARPPGGGGPLSKGEVKLLVNHFSVDYPKESTFFHYEIRIKLGDGPNRKLSKAELLTVKNELFEHESLQELSSAVAYDGERNLYTCAELPEDCIVPVSKFRVKDSSRTYIVSVKLKKPLPLSQLLEQRPGPRDVMQGLDVIVREASSFGKIVLGQGFYPQSGSEAISDSNIVALKGTQQSLKCTQKGLILCVDYSVLPCWKAGSVLDLVKTMKFMEYPLLEDQLKKLNNALKGLCVTVSHRKTEEKYTVKGLTDKPADQITFKDSKSGQTTKLIEYYKETYKKEIEHPMLPCLDLSKSKSKQNYVPIEFCNIPEGERYPVARLDDKKSDNKGEQEKPSTKTTLRKISIKVASSRKEEILDLVGNAQDGPCRGKIAQRFRISLDAAMMEVTGRILAPPTLELGTGTSRGQTFKFTIHQDDCQWNWKLKKYDKRVVAHGGTLNCWGVVDFSEGDLESKFIDKVVRKCSALGMVMTRKPCYEHVSNMEVLSDPKSLRDALIEAKRAAEEEDKKLQLLFCPMLNRCHGYKTLKLMCETELGIQTQCFLSTAAKLDEKRQDQYITNLALKINGKIGGSNMQLDPDSIPVVSAKDFMFIGADVNHPPPGNVSKDIPSIAAVVASVDKGASKYVTRIRAQYHRCEMIQNLGDICKELIGAYEKVNKKKPDSIIYFRDGVSDGQFDMVLNEELADMENKIMVGDYPKITVIVAKKRHHTRLFPKDRNQRQTKNGNVLPGTVVDTDVVDPTAYDFYLCSHKGEVGTSRPTHYYSLLDEHGFASDDLQKLVYNLCFVFARCTKPVSLATPVYYADLAAYRGRLYYEGMMMLQPAASAASASEAMMPAAQPQAAAAAAAAASPSSSAASSSEGMTASQPQAPAAEAASSSAGAADFRELPPMHGDLLNNMFFL
What is the function of this protein?
Probably involved in the RNA silencing pathway.  May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).
What are the official names of this protein?
Protein argonaute 3, OsAGO3.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
Protein: ALBA1_SULTO
Sequence: MSSTATPTPSNVVLVGKKPVMNYVLAALTLLNQGVSEIIIKARGRAISKAVDTVEIVRNRFLPDKIEVKEIRIGSQVVTSQDGRQSRVSTIEIAIRKKA
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
What are the official names of this protein?
DNA/RNA-binding protein Alba 1.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: YF013_HUMAN
Sequence: MHQTHAIQRLEVLPSFSNESPTSRETSESWTNQDDIFYAYASMSPGAEHRGTTQLLRFQLAPIKKLEGSLQTHFLLSSLHPRMTFPGRAGGGEAGSRPPRRPWAGILILQLPSTRGGRRSGHGAVRSWGPWKVVAEQPVGGTDPPAHGGRGRPSPNENT
What are the official names of this protein?
Putative uncharacterized protein FLJ45825.
Protein: VF175_ASFWA
Sequence: METNCPNILYLSGITIEECLQSKKTATDTLNTNDDEAEVEKKLPSVFTTVSKWVTHSSFKCWTCHLYFKTVPKFVPTYMRENERGEIEMGVLGNFCSFSCAASYVDVHYTEPKRWEARELLNMLYRFFTSQWISYIKPAPSYTMRKEYGGKLSEEAFISELHTLEESISSKHIFI
What are the official names of this protein?
Uncharacterized protein B175L, pB175L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B175L family.
Protein: NUDL_SHIDS
Sequence: MEYRSLTLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASVIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: SURE_SYMTH
Sequence: MALVLLTNDDGIFAPGINALRARMEQIPGLEVWAVAPDRERSASGHAITTYRPLFPVRVEIPGAVAPCISVTGTPADSAKLAIEAILPRRPDLVISGINRGANLGTDIFYSGTVAAALEGPILGIPALAVSLDSMTSSDYSAAADFAAQLALKVLEEGLPEGTLLNVNVPALPREAIKGVRVTKVGRRIYRDQWVRRMHPRGQEYYWLAGELAEIHNDRESDVSAVEAGYISVTPVHLDLTRYDQMDRLRQWNLTF
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_TREPA
Sequence: MGLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLPQDRGRAFAPCAQEAAGKPTGAGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLDDCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWFPFFSDPVFVSPFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWALMSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNGGTGLLKVVLLRFFHVRILSRVRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLFKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PALI1_KLULA
Sequence: MSHFKIVFLTSLSLALVFELFNTISVPITSHLFISEYNGYKFGVFGWCKVDGSICSPIRMGYSLDDILLFNDNEYLHLPNHAKYALSKLLLVHVLSFVCVLVFWLFAILICIKWLNTSKSVLLFAVGWSMVTFMVSLLGFLIDVLMFASHVTWSSWLMLVSAFFVALSGILLCLMIRDLSYRRFVKLQGEVDVCVPMTEPRDPDELNEIWKKKTSKREIL
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator palI/RIM9 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the palI/RIM9 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBD_CHLSC
Sequence: MTITLGRFTKEENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CHEC_CHAGB
Sequence: MRSPPREARLRMAVEAIGKNKNLSIRAAARQYNVPEATIRHRCTGRSARRDLPANSRKLTDLEERTIVQYILELDARAFPPRLRGVEDMANHLLRERDAPPVGKLWAHNFVKRQPQLRTRRTRRYDYQRAKCEDPKVIGEWFTLVQDAKAKYGIVDDDVYNFDETGLMMGIIFAGQAYGRLIDELMRAHINHITKLEFLCAFREAFFASMTEKNIQGGFSGAGIVPFDPERVLSKLDVKLHTPTHPDSRPGTAQPWASKTPYNAQETRSQSDFIKTRISSYQNSSPASVLVAVDQLTKGATAVMHQVALLQSEVSSLRKANEPLSKRRKAKRTRIQLGGPLTVQDAQDPLDQRDVGKGALQETQPDSSGAGGARAKVRRCNSCCKVGESASLAYMRRSLIIYVRSYNDF
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536).  Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C. globosum (PubMed:33622536).  The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317).  Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317).  Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317).  Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317).  The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317).  Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317).  The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization (Probable).
What are the official names of this protein?
Chaetoglobosin A biosynthesis cluster protein C.
What are the subcellular locations of this protein?
Nucleus.
Protein: CKR1_CHICK
Sequence: MEPYVLLDPRQKALYRDVMQESYETLMSIAQGLVNHKAAEEDAVGLKEDAVGSEEPQTHPPHNPAQNRTAGSHRRKAKRPDKAAPLGVAQTPPAAPTPKRDGVKPSRVRDRPFGCPDCGKSFPWASHLERHRRVHTGERPYSCPECGESYSQSSHLVQHRRTHGGDRPHKCQHCGKPFAGAAQLLAHSRGHAADRPHRCGDCGKGFVWASHLERHRRVHTGEKPYECPECGEAFSQGSHLTKHRRSHARSGRTAAPLRKCFGQSSDLVQHRSRAGKKPQRCAECGKAFRAAPPLRRHRRERSHRCGDCGKGFAWASHLQRHRRVHTGERPFPCGLCGERFSQKAHLLQHGKTHRPERPYKCGDCGKRFENAPPFLAHRRGHAALKSFTCGDCGKGFAWASHLQRHRRVHTGEKPYECPECGEAFSQGSHLTKHRRSHGPKAPLLPVQGRGEAGEPLRASPLSSGAEQRDGRRAQRGGVEEEVGWGANRAVLRGRSAHSWPRSHLPMLGC
What are the official names of this protein?
Zinc finger protein CKR1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDFA_YERPD
Sequence: MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE
What is the function of this protein?
Efflux pump driven by the proton motive force.  Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
What are the official names of this protein?
Multidrug transporter MdfA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. MdfA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROE_PARDP
Sequence: MVDTLPTPKHAPLAGVIGWPVAHSRSPRLHGHWLERYGIAGHYVSLPVMPEHLAEVLRAMPHMGFVGANVTIPHKESVLALADVVTDRAALIGAANTLIFRADGKIHADNTDGYGFIANIRQHAPDWIPDLGPAAVIGAGGAARAVVASLLESGVPELRIANRTRIRAEQIRAEFGAKVVVYDWAQAGNMLEGAMTVVNATSMGMEGKPPLRVPLEALAPSTLVTDLVYTPLMTPFLAEAQARGCEVVDGLGMLLHQAAPGFERWFGQRPEVDDDLRRAVLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.