PharMolix/UniProtQA huggingface dataset:
Protein: TRHO_SHEWM
Sequence: MSQVVVCALYKFVSLPNFESIQKPLLAHMESAGIKGTLLLASEGINGTVAGSQLAIDNLLQWLAKQDGLDSIVHKLSFDETMPFYRTKVKLKKEIVTMGVEGIDPLKVVGTYVKPKDWNQLISDPEVLLVDTRNEYEVQIGTFKNAVDPKTDTFREFPAYVKEHLDPAKHKKVAMFCTGGIRCEKSTAYLKEQGFDEVYHLEGGVLKYLEEVKQEESLWEGECFVFDNRVAVNHALEKGQYDQCNACRMPITELEKASEAFVQGVSCPHCIDNISEKQRQRFEERERQMQLAAKRGEAHIGSDVGAVIQSRRDNKENLKKSQVKLNNKKYNK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: ARAB_SALTI
Sequence: MAIAIGLDFGSDSVRALAVDCATGDEIATSVEWYLRWQEGRYCDGPNNQFRHHPRDYMESMEAALKAVLAQLSAAQRANVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEADEITRLCHKPGKVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQAAVSWIELCDWVPALLSGTTRPQDIRRGRCSAGHKTLWHESWGGLPPASFFDELDPCINRHLRYPLFSETFTADLPVGTLCAEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNTLVKVIGTSTCDILIADKQSVGDRAVKGICGQVDGSVVPNFIGLEAGQSAFGDIYAWFSRVLSWPLEQLAAQHPELKTQINASQKQLLPALTDAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPALFGGLVASTAFGARAIQECFTEQGIAVNNVMALGGIARKNQVIMQVCCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPAAQQSMASAVERTLRPRPEQAQRFERLYRRYQQWALSAEQHYLPTAAPAPTTPANQAILTH
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: QUEA_FRATW
Sequence: MKTDDFDYKLPEELIASYPLENRDASRLLKLNKQTGEIADYKFTDFIDFINPGDLLVFNNSKVMLARLYGSKTTGAKLEYLIERIKNPKLFETHIKANRSPAIGSEIYVEDTLAKVLDKDGGMYLLEIQGDKDIYQLMEEFGHIPLPPYMKRDDEEFDAERYQTVYAQDLGSVAAPTAGLHFSKELMQQIKDKGVDIAYITLHVGSGTFKPVQVDDVESHKMHAEVISVPVEVCQKIRQTKENGGRVIAIGTTSVRSLETAGQNGQIEPYQGETDIFLYPGKKFNVVDAMITNFHLPKSTLIMLVSAFADKEKIIKAYEHAIAERYRFFSYGDAMFIF
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDAS_ECOLI
Sequence: MKKENYSFKQACAVVGGQSAMARLLGVSPPSVNQWIKGVRQLPAERCPAIERATRGEVLCEELRPDIDWSYLRRSACCSQNMSVKQLNDSNKSSFDHT
What are the official names of this protein?
Uncharacterized protein YdaS.
Protein: RL22_PARXL
Sequence: MEVKAIHRGARISAQKTRLVADQIRGLPVDKALNVLTFSPKKAAGIVKKVVLSAIANAEHNEGADIDELKITSIYIDKAASLKRFTARAKGRGNRIEKQSCHITVTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RS6E_METJA
Sequence: MPTAKFVVADPKTGRCYQIEADNTPLVGKKIGEVFDGKIIGLEGYKLQIRGGTDSSGFPMRPDIHGSRKVRVLLSAPPGFKPKRKGERRRKTVRGNTIAPDIVQINVKVVEYGEKSIPELLGLEGGENQEQ
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: TUS_SALNS
Sequence: MSRYDLVERLNGTFRQIEQHLAALTDNLQQHSLLIARVFSLPQVTKEAEHAPLDTIEVTQHLGKEAEALALRHYRHLFIQQQSENRSSKAAVRLPGVLCYQVDNATQLDLENQIQRINQLKTTFEQMVTVESGLPSAARFEWVHRHLPGLITLNAYRTLTLINNPATIRFGWANKHIIKNLSRDEVLSQLKKSLASPRSVPPWTREQWQFKLEREYQDIAALPQQARLKIKRPVKVQPISRIWYKGQQKQVQHACPTPIIALINTDNGAGVPDIGGLENYDADNIQHRFKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIRB_KLEOX
Sequence: MTKPVLVLVGHGMVGHHFLEQCVSRDLHQQYRIVVFCEERYAAYDRVHLTEYFAGRSAESLSLVEGDFFTQHGIELRLSESVASIDREARVVRDAFGHETHWDKLVLATGSYPFVPPVPGHNLEGCFVYRTLDDLDQIAARAATARRGVVIGGGLLGLEAANALKQLGLETHVVEFAPNLMAVQLDNGGAAMLREKISELGVGVHTSKATTEIVRNEQGLQLNFRDGSSLATDMLVFSAGIRPQDALARSGGLSVGERGGICIDNQCRTSDPDVLAIGECALWENKIYGLVAPGYQMAARRAATLAGEAGSFSGADMSTKLKLLGVDVASFGDAQGRTPGCQSYQWTHGPQQVYKKIVVSADGKNLLGGVLVGDAGDYATLLQMMLNGMALPKHPESLILPALEGSRPKALGVAALPDGAQICSCHNVSKGDICQAVSGGAGDMAAIKSRTKAATGCGGCSALVKQVMEYQLAEQGVEVKKDICEHFPWSRQEIYHLVRVNHIRTFEQLIARYGQGHGCEVCKPLVASVLASCWNEYLLKPAHLPLQDTNDRYFANIQKDGTYSVVPRMAAGEVTPDGLIAIGQIAKRYQLYSKVTGGQRIDLFGARLEQLPAIWRELAEAGFETGHAYGKSLRTVKSCVGSTWCRYGVQDSTGLAVTLEHRYKGLRAPHKIKMAVSGCTRECAEAQGKDIGVIATEKGWNLYVCGNGGMKPRHADLFASDLDEATLIRSIDRLLMFYIRTADRLQRTSTWMDNLEGGVDYLREMILEDSLGIGEELEQEMARVVESYQCEWQTTLNDPQRLALFRSYVNSDEPDETVQRQTLRGQPQLAPFAAQGEPALPSRPWQAICDLDAIPQQAGIGARLGERQIALFRFGDQVYALDNLEPGSEANVLSRGLLGDAGGEPIVISPLYKQRIRLRDGRQCDGGEQAVRAWPVKVENGKVWVGNQQLLARAEAS
What are the official names of this protein?
Nitrite reductase [NAD(P)H] large subunit.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: IL40_MOUSE
Sequence: MALLQLLLFAMLAACGFSEEQTEGITIAYKVLEVYPQSRRVLITCDAPEASQPITYSLLASRGILVAKKVVHDSVPASFNINITIKSSPDLLTYSCQATSNSGTYGPSSRLQMYQELWAKPVSQLQADFVLRHGDSGPTVELSCLASSGSPPITYRLVGNGGRVLAQQRPLHGKPANFSLPLSQTTGWFQCEAENDVGVDSSARIPLPRAEARAKLVTTLAGELPLTPTCILAGSLVSIAVIASRMLSSTGL
What is the function of this protein?
Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses (PubMed:28978694).  Involved in lymphocyte B cell development and immunoglobulin/IgA production (PubMed:28978694).
What are the official names of this protein?
Protein IL-40, Interleukin-40, IL-40.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAB_SORC5
Sequence: MPRYSITTFGCQMNVHDSERMHDVLRCAGYTEAGSADEADVLVLNTCSVREKAEQKLRSEVGRLARWKRERADRVLVVAGCVAQQEGERLLKQMRAIDVVVGPDNIPELPGLLGDLAIGGLPIARTVFDLDAPRFLVASPPSPSSSSSPRAAPTAFVTVMKGCDERCSFCIVPHTRGPERYRPSDEIVAEIAALVAAGTREVTLLGQTVNSYRDPLGALPRAPGASADDPDESEFAALLRRVAADVPGLARLRYTSPHPRHLTPSLVLAHAELPVLPRHVHMPVQSGSDRVLRRMIRRYTRAEYVARTRALVEAVPGLTLSTDIIVGFPGETEDDFAATLSLVREVGFKGLFGFKYSRRPHTPALKLPDDVPEGVKGERLARLFEESEALLAAHLSALVGTTQEVLVEGRDKERGHGGAGGALWSGRTGRHEIAHIDGAGELDLLGEVVEVSIARANKHSLQAELTEAARAAARPRQRGGLEPRPARRSLPVVAAEGG
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGF11_DROPS
Sequence: MPTSAAPVPAVAAQSPTTRKAIANNFRELTKDPKKLDEAANQLYESLLEDAVTGIFIEVHHLRKIGNLSALDGVAEESAHRICDVPNLDIFGVSTAKKAIDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGTSASSNSSYVHSGANAGGTDDEDDVDWSSDKRKKKSTQNSRNNGSKKNNGKTF
What is the function of this protein?
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Binds independently on SAGA to promoters in an RNA-dependent manner.  Binds to mRNA and is essential for total mRNA export from the nucleus.  Required to counteract heterochromatin silencing.  Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe.  Required for expression of ecdysone-induced genes such as br/broad.
What are the official names of this protein?
SAGA-associated factor 11 homolog.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: TSAD_GEOSM
Sequence: MLVLALESSCDETAAAVVKDGRTVLSSIVASQISVHAEYGGVVPEIASRKHLESVSFVVEQALAEAGVGLDRIDGIAVTQGPGLAGALLVGISVAKGLAFGRSLPLVGVNHIEGHLLAVFLEAPVQFPFIALAVSGGHSHLYRVDGIGRYQTLGQTVDDAAGEAFDKVAKLIGLPYPGGVAIDRLAVSGDPKAIKFPRPLLHDGTFNFSFSGLKTAVLTHVGKHPEAKEAGINDLAASFQAAVCEVLTKKTAAAVAATGIKRLVVAGGVACNSALRRSMAEYAAANGVELSIPSPALCADNAAMIAVPGDYYLGLGVTSGFDLDALPVWPLDKLALRLKEHC
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_SALHS
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: THIO_BORBU
Sequence: MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGVQSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: ARAA_ERWT9
Sequence: MTQINNRSVWFVIGTQHLYGVETLRQVERHGQQVVDSLNRSGILPFRLQIRPLVKTPDEALALCREANYDSECYGIMTWLHTFSPAKMWIGGLSVLHKPLLQFHTQFNAEIPWDSMDMDFMNLNQTAHGGREFGFIGARMRLPHQVVTGHWQDERTLLRIGQWMRTAAALQAGRQLKVARFGDNMREVAVTEGDKVAAQIQFGYSVNGWGVGDLVEVINQVKDGDVNALVDEYESRYVFSAAAAVGGAKRQNVLDAARIELGIGRFLDDEGCRAFTTNFQTLHGMTQLPGLAVQRLMQQGYGFAGEGDWKTAALLHICKVMAGDLTGGTSFMEDYTYHFAPDNDLVLGSHMLEVCPSIASEARPLLDVQPLGIGGKADPARLIFAAKAGRAVNASVIDMGDRFRLLVNVLDAVEPPRALPKLPVARALWHAQPSLATASEAWILGGGAHHTVFSQALTVDDLRLYGEMLGIEVVVIDEQTTLHGLRDALRWNEAYYRLNQR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: SYS_CAMJ8
Sequence: MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKTALEEFQAFQNKFSKELATAEDKESLKAKLSENKSKINEQSVKVNALENELEEIAHAIPNIPDECVPVGEDEDENVELKKVLNPPSFDFTPKEHFELGESLNWLDFVRGVKISQSRFCVLKNEGALLSRALVNYMIDFNRSHGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEILASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKPEQSDSVFNEMLECASDLLSSLGLAHRHLMLCTGDLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAKIRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGKIHIPDALKKYF
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO1_THEFI
Sequence: MTPLFDLEEPPKRVLLVDGHHLAYRTFYALSLTTSRGEPVQMVYGFARSLLKALKEDGQAVVVVFDAKAPSFRHEAYEAYKAGRAPTPEDFPRQLALVKRLVDLLGLVRLEAPGYEADDVLGTLAKKAEREGMEVRILTGDRDFFQLLSEKVSVLLPDGTLVTPKDVQEKYGVPPERWVDFRALTGDRSDNIPGVAGIGEKTALRLLAEWGSVENLLKNLDRVKPDSLRRKIEAHLEDLHLSLDLARIRTDLPLEVDFKALRRRTPDLEGLRAFLEELEFGSLLHEFGLLGGEKPREEAPWPPPEGAFVGFLLSRKEPMWAELLALAAASEGRVHRATSPVEALADLKEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTHPEGVARRYGGEFTEDAAERALLSERLFQNLFPRLSEKLLWLYQEVERPLSRVLAHMEARGVRLDVPLLEALSFELEKEMERLEGEVFRLAGHPFNLNSRDQLERVLFDELGLTPVGRTEKTGKRSTAQGALEALRGAHPIVELILQYRELSKLKSTYLDPLPRLVHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRKAFVAEEGWLLLAADYSQIELRVLAHLSGDENLKRVFREGKDIHTETAAWMFGLDPALVDPKMRRAAKTVNFGVLYGMSAHRLSQELGIDYKEAEAFIERYFQSFPKVRAWIERTLEEGRTRGYVETLFGRRRYVPDLASRVRSVREAAERMAFNMPVQGTAADLMKIAMVKLFPRLKPLGAHLLLQVHDELVLEVPEDRAEEAKALVKEVMENAYPLDVPLEVEVGVGRDWLEAKQD
What is the function of this protein?
Has 5'-3' exonuclease activity and no 3'-5' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, thermostable, TFI polymerase 1.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: FOLD_HYPNA
Sequence: MTATRLDGNAVAADVRSAVAAAVSALPGQPCLAVVLVGEDPASEVYVRNKVKMTEAAGMVSIHHRLPADTGQAEVERLIESLNADPEVDGILLQLPLPKGLDADAAIEKINPDKDVDGLTEVSAGRLSLGKPGLRPCTPVGSVILAKRALGPDLSGKNVVVIGRSILVGKPAALLFLAENCTVTIAHSKTADLANVCRSADILVPAVGRPEMVRGDWVKPGAAVIDVGINRIPAPEKGEGKTRLVGDAHYESCAEVAGFITPVPGGVGPMTIACLLRNTVLAACARRGWTVPEGL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: 120L_IIV6
Sequence: MFKFILLCFCINFAFSSPVIQFFIEDEIKLEQPQPIIITSKNKNLPQILFKNTYDNNNIENVGGSCYCTNYMGAIDQGITQMCCSSSGGKMSGNICISNWSSSGFGNCCKATGAYYGGCF
What are the official names of this protein?
Uncharacterized protein 120L.
Protein: SIGA_BACSP
Sequence: MANDQHTELETEFTLDQVKDQLIEQGKKRSSLNYKDIMEKLSPFDQDPEQMDEFYEHLGDLGIEVVNENDEEVSNLRQGEDHDGNDNDDFNFDDDLSLPPGIKINDPVRMYLKEIGRVPLLSADDEVELAKRIMNGDEEAKRRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLIKAVEKFDHNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVSRQLLQELGREPTPEEIAAEMELSVEKVREIMKIAQEPVSLETPIGEEDDSHLGDFIEDQEALTPADAAAYELLKEQLEDVLDTLTEREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NACB_COCIM
Sequence: MDQAKLARLQQSVRIGTGKGTPRRKTKKVHKSSGTDDKKLQTSLKKLNVQPIQAIEEVNMFKEDGNVIHFAAPKVQASVPSNTFAIYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKKEGEAKKEGEEDDEDIPDLVGETFESKVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: 3SAN_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNQLIPPFYKTCAAGKNLCYKMFMVAAPKVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Basic protein that bind to cell membrane and depolarizes cardiomyocytes.  This cytotoxin also shows lytic activities, on many other cells including red blood cells.  Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes.  It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation.  Inhibits protein kinases C (By similarity).  It binds to the integrin alpha-V/beta-3 with a moderate affinity (PubMed:16407244).
What are the official names of this protein?
Cytotoxin 6, Cardiotoxin 6, CTX6, Cardiotoxin A6, CTX A6, Cardiotoxin N, CTXN, Ctx-N, Cytotoxin N.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: SHO1_AJECH
Sequence: MVTYSANYSTSFQKRSPFAVHNRRSNMARMDFNNIVGDPFALITISTSLIAWLLSFATCVISDIQGAFPNFAWWAVGYMLCAIIGISLVLASQTSHVYGVAIVGYLAAGLTFTTLAVNSLIYDDQASKQAGAAGFILQSMVTIVWIFYFGSSSQTSSRPYLDSMGAGKEHPSYRNSKPLSTNYGARPETVVSGNQPPQMYTSAQLNGFETSSPVSGYPPTAANGAENGTQNRFVGPAIGSQSNLGGGSTLGADHPSTPNEVSQPTVYPYRAKAIYSYEANPDDANEISFSKHEILDVSDVSGRWWQAKKASGETGIAPSNYLILI
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGF23_TETNG
Sequence: MDVNRRIGVKDALLALLLALLQGCPLGETAPNASPLVGSNWGNPRRYVHLQTSTDMSNFYLEIRLDGTVRKSTARTSYSVILLKADTRERIAILGVKSNRYLCMDLEGSPFSSPTCIRDDCLFNHSLLENNRDVYYSSRTGILFNLEGSRQVFVVGQNVPQTSLFLPRTNTVPLERLLLHRDKRNQVVDPSDPHRVAVGRAEEGSDSRALQEDDADLEVETEVEVGDDGRNASRERLQAPSDHDPWGVFSSNPGSPRSSGTVG
What are the official names of this protein?
Fibroblast growth factor 23, FGF-23.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPP_PASMU
Sequence: MKLVQVQHPLVKHKLGLMRSAEINTKKFRELATEVGSLLTYEATADLETEKVIIDGWCGPVEIDQIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGMYRDEETLEPVPYFQKLASDLEERLAIVVDPMLATGGSMIATIDLLKAKGCKHIKVLVLVAAPEGIKALEAAHPDIELYTASVDSHLNEQGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MYX2_CRODU
Sequence: KILYLLFAFLFLAFLSEPGNAYKRCHIKGGHCFPKEKICIPPSSDFGKMDCPWRRKSLKKGSGK
What is the function of this protein?
Cationic peptide that possesses multiple functions.  It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.  It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism.
What are the official names of this protein?
Myotoxin-2, Crotamine-2.
What is the protein family that this protein belongs to?
Belongs to the crotamine-myotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_SHISS
Sequence: MAIERTFSIIKPNAVAKNVIGNIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSVESAAREIAYFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB1_BURM7
Sequence: MSTAALVEGKIVQCIGAVIDVEFPRESMPKIYDALILEGSELTLEVQQQLGDGVVRTICLGASDGLRRGVVVKNTGNPISVPVGKPTLGRIMDVLGRPIDEAGPIESENKRSIHQKAPAFDELSPSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELINNIAKEHGGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEHFRDEGLDVLFFVDNIYRFTLAGTEVSALLGRMPSAVGYQPTLAEEMGKLQERITSTKKGSITSVQAVYVPADDLTDPSPATTFGHLDATVVLSRDIASLGIYPAVDPLDSTSRQIDPNVIGEEHYSITRRVQQTLQRYKELRDIIAILGMDELSPEDKLSVARARKIQRFLSQPFHVAEVFTGSPGKYVPLKETIRGFKMIVDGECDHLPEQAFYMVGTIDEAFEKAKKIQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RR15_OENEH
Sequence: MVKKAFISVISQEENRGSVEFQVVSFTNKIRRLTSHLEFHRKDFLSQRGLRKILGKRQRLLSYLSKKDKVRYTELISQLDIRELTTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ZN530_HUMAN
Sequence: MAAALRAPTQQVFVAFEDVAIYFSQEEWELLDEMQRLLYRDVMLENFAVMASLGCWCGAVDEGTPSAESVSVEELSQGRTPKADTSTDKSHPCEICTPVLRDILQMIELHASPCGQKLYLGGASRDFWMSSNLHQLQKLDNGEKLFKVDGDQASFMMNCRFHVSGKPFTFGEVGRDFSATSGLLQHQVTPTIERPHSRIRHLRVPTGRKPLKYTESRKSFREKSVFIQHQRADSGERPYKCSECGKSFSQSSGFLRHRKAHGRTRTHECSECGKSFSRKTHLTQHQRVHTGERPYDCSECGKSFRQVSVLIQHQRVHTGERPYECSECGKSFSHSTNLYRHRSAHTSTRPYECSECGKSFSHSTNLFRHWRVHTGVRPYECSECGKAFSCNIYLIHHQRFHTGERPYVCSECGKSFGQKSVLIQHQRVHTGERPYECSECGKVFSQSSGLFRHRRAHTKTKPYECSECEKSFSCKTDLIRHQTVHTGERPYECSVCGKSFIRKTHLIRHQTVHTNERPYECDECGKSYSQSSALLQHRRVHTGERPYECRECGKSFTRKNHLIQHKTVHTGERPYECSECGKSFSQSSGLLRHRRVHVQ
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 530.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.