PharMolix/UniProtQA huggingface dataset:
Protein: CCR5_CERAT
Sequence: MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSPHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEASERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNMG_SHELP
Sequence: MHFHERFDVIVVGGGHAGTEAALASARMGSKTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEIDALGGAMAVATDHAGIQFRTLNSSKGPAVRATRAQADRALYRAKIQQILQNQPNLRLFQQAVDDLIVGNDRVIGVVTQMGLAFEAPAIVLTAGTFLSGKIHIGLENYSGGRAGDPPSISLADRLRELPIRVGRLKTGTPPRIDANTINFDLMTEQKGDDPLPVMSFIGDVKDHPKQISCFITHTNERTHDIIRGGLDRSPMYSGVIEGIGPRYCPSIEDKINRFADKSSHQIFIEPEGLNTNEIYPNGISTSLPFDVQLNLVRSIQGMENAEIIRPGYAIEYDYFDPRDLKNSLETKAISGLFFAGQINGTTGYEEAGAQGLLAGMNASLQVQGKEAWCPRRDEAYLGVLVDDLSTLGTKEPYRMFTSRAEYRLLLREDNADLRLTEKGRELGLVDDDRWAKFNAKREAIELELQRLRSQWIHPNSPLVDALNPHLNTPITREATFEELLRRPELDYPKLMSVEGFGPAIEDQRAAEQVQIQVKYSGYIQRQQDEIDKAIRHEKTGLPQDLDYQEVPGLSNEVIAKLNDHKPDTVGQASRISGITPAAISILLVHLKKRGLLRKSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_COXB2
Sequence: MTDQLITLIWIIIKIVLILVPLLVAVAFITLAERKVIGYMQSRVGPNRVGFRGLAQPIADIFKLLLKEVIIPTASSRYLYLIAPILSLVPALAAWAVIPFAQGWMLANVNAGLLFLFAMTSLGVYGILVAGWASNSKYAFFGALRSAAQVVSYEIPMGFALVGVLLAAGTMNLQGIVLRQSGGLWHWFWLPLLPLFVTYWITAVAETNRAPFDVAEGESEIVAGFHVEYAGVTFALFFLAEYANMVLVSAIATVIFLGGWLSPFQGIPGLESLFAWVPGIVWFVLKLSLFIFTYFWMRATFPRYRYDQIMRLCWKVLIPVTLVWIIILALAIEFHWTHWL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYGA_AFIC5
Sequence: MRPEKSFQGLILTLQRYWADYGCIILQPYDMEVGAGTFHPATTLRALGPKRWNAAYVQPSRRPKDGRYGENPNRLQHYYQFQVILKPSPEDIQDLYLKSLAAIGVDAALHDIRFVEDDWESPTLGAWGLGWECWCDGMEVSQFTYFQQVAGVECAPVAGELTYGLERLAMYVQGVDNVYDLNFNGRDGAEKVTYGDVFLQAEQEYSRHNFEHADTAMLFEQFKMAEGACKKYLDAGWASDKKDKHLMALPAYDQCIKASHVFNLLDARGVISVTERQSYILRVRELAKACGEAWIHTEAGGVRG
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_PARDP
Sequence: MAGDDEDRAVPAAEGAPPPSALPPVSGLDVKAAEAEHARLSEEVAQANLAYYQEDAPFISDAEYDASKRRLEEIEARFPDLAHSGSPTAQVGAAPDTRFAKVPHRLPMLSLENGFSQGDVEAFVQRVRSFLNLASGAPLEVTAEPKIDGLSLSLRYEGGRLVQAATRGDGAVGENVTANARTIADIPGQLSGDGYPEVLEIRGECYMSHEDFEKLNQSETGRVFANPRNAAAGSLRQLDPSVTAARPLRFFAYAWGEVSASFAGTQMEAVRRMQAFGFQTNPLTRICASVSEMLSAWAEIEQMRATLGYDIDGVVYKVNDLAYQARLGMRSTTPRWALAHKFPAERAWTRLEAIDIQVGRTGALSPVARLHPVTVGGVVVSNATLHNEDYIAGRGADGSEIRGGKDIRIGDWVEVYRAGDVIPKVADVDLAKRPSEAEPYAFPTTCPECGSPAIREEGDSVRRCTGGLICPAQAVEKLRHFVSRAAFDIEGLGAKLVEELFRDGWIAEPADIFTLQDRYGPGQLTQLKNREGWGEKSAASLFQAIEKRREIPLARLLFALGIRHVGEVAAQDLARHYGSWEALEIALDTARPAALAHRVAEDAALAEREAARAEGRRARPSEARAAALAQVDLSPEATAAWTGLIAADGIGPVLAMSLSDAFANERERAAIDRLVSFLTVLPPEARATDSAIAGKTLVFTGTLEKMTRAEAKARAEALGAHVAGSVSAKTDLLIAGPGAGSKAKKAAELGIKVIDEDEWLAIAQG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HRCA_TETHA
Sequence: MLTQRQDNILHQIIHNYTNLGKPIGSKTLMEEGIAASSATIRNEMKTLEEYGLLVKPHSSSGRIPSLKGYRYYVDYLLEPEKLKKSEVDVMQQSLGKDFHEINDIIEQSAKILSKLTSYTALSIGPDVSNRKLTGFKMVPLNNRQVIAIIVTDKGNVENQVFSIPKSVDSEDLEKMVRIINDKLIGEPLLIVYQRLGTEIPMILHKYFQTTEGILDLFNNMLSEAFEEKIFVGGQMNLLNSDQIQNIDQFKSMLFMENSKQLNELLSTKDQPIQIRIGSELGNDLLSDMSLIQANYEIKDHGNGTIALLGSASMPYSKMLSLLDVFRQELAETLDDYYRSIDSFG
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: Y610_CALS4
Sequence: MKKHIFEDIILQNALNFTEEVVEIFGDLLNKGMNITELVARIKELTDKLGRGAIEAIIEELDRIIKEDKRRKEKWVVERKDKKRLTTVLGDIEYERTYYKSKEDGRYTYLVDDALEIGRHDRIEKGVKIKLVENAIEESYERSSKKACPEELSKQTVLNAIREIGEVEVKREIKEKKEVRVLYIEADEDHVPLQDGRDETPRLVYIHEGREEKNGRNVLKNVYYKAYVGEKPEDIWIDVANYIEDNYKEEKIEKIYIAGDGAPWIKEGLKWILKSRFVLDRYHLNKYVLKATSKEPKYRDKIWRAINEGDKERVKKVFDELIKAAEEEREKEKIKEAKKYILNNWEGIKIYNEDEDVIGCSAEGHISHVFSARLSRNPLGWSREGLKLMAKLRVFSKNGGDLREVEWGKKKNINAGSYKLTKKQIKEAVRRVKTSTNEKINNITVLNIGKVTPIYRVLRALKYAQVI
What are the official names of this protein?
UPF0236 protein TTE0610/TTE0881/TTE1053/TTE2432.
What is the protein family that this protein belongs to?
Belongs to the UPF0236 family.
Protein: MNME_PSEPW
Sequence: MNTVRETIAAIATAQGRGGVGIVRLSGPLAAKAGQLITGRTLTPRHAHYGPFRDQEGLVLDEGIALFFPGPNSFTGEDVLELQGHGGPVVLDMLLQRCVQVGCRLARPGEFSERAFLNDKLDLAQAEAIADLIEASSSQAARNALRSLQGEFSKRVHSLTEALIALRIYVEAAIDFPEEEIDFLADGHVLSMLDSVRAELSTVQREAGQGALLRDGMTVVIAGRPNAGKSSLLNQLAGREAAIVTAIAGTTRDILREHIHIDGMPLHVVDTAGLRDTDDHVEKIGVERALKAIGEADRVLLVVDSTAPEASDPFALWPEFLDQRPDPGKVTLIRNKADLSGEPVGLEQCDDGHVTITLSAKGDDQGLLLLRDHLKACMGYEQTAESGFSARRRHLDALRQACAHLEHGRAQLTLAGAGELLAEDLRQAQHALGEITGAFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_SYNPW
Sequence: MRVLGLMSGTSADGVDAALAQFHGRPEAPHWDLLNTASVPYPSALKERLIRMAQGEPTRACDVLEMSEAVTEIQAAAAHLCDPEQSASLLGCHGQTMWHRPPVPSGESSRESGRRGASWQMLQAPLLAHLSGRPVIHDFRAADLALGGQGAPLVPMADAALMGRIDGWRGLLNLGGIANITLIPPNAGPDRQHPVLGWDCGPANTLMDLAMTRLSGGQDTFDLDGALAGRGTVCEETLERWLQEPYFLSSPPKSTGREVFGQDDLNRRLQQLAPHSAANQLATLTAFSAAVVAQDLRRLTATGQPQPVELLVAGGGCRNQTLMRQLRRRCLGVRVRPSSDLNLPTQFREALVFALLAWWHQRGHPGNAPAITGAAKATVLGLRVNPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: TRUB_PSEP1
Sequence: MAQVKRIRRNISGIILLDKPLGFTSNAALQKVRWLLNAEKAGHTGSLDPLATGVLPLCFGEATKFSQYLLDSDKGYETVMQMGQTTNTGDAEGEVLQTRDVTVGRADIEALLPRFRGPISQIPPMYSALKRDGQPLYKLARAGEVVEREARSVTINRLELLECEGTRARLSVGCSKGTYIRTLVEDIGEALGCGAYVAELRRTQAGPFALAQTVTLEELEQAHAEGGNEALDRFLMPSDSGLQDWPLVSLSEHSAFYWLHGQAVRAPDAPQFGMVRVQDHNARFIGIGEVSEDGRIAPRRLIRSE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: IMDH_STRP6
Sequence: MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSKMAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRYRISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERILHEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVVKVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHDVQITNEAPNYSVH
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: CYSH_MYCTA
Sequence: MSGETTRLTEPQLRELAARGAAELDGATATDMLRWTDETFGDIGGAGGGVSGHRGWTTCNYVVASNMADAVLVDLAAKVRPGVPVIFLDTGYHFVETIGTRDAIESVYDVRVLNVTPEHTVAEQDELLGKDLFARNPHECCRLRKVVPLGKTLRGYSAWVTGLRRVDAPTRANAPLVSFDETFKLVKVNPLAAWTDQDVQEYIADNDVLVNPLVREGYPSIGCAPCTAKPAEGADPRSGRWQGLAKTECGLHAS
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COG2_DROME
Sequence: MHDPVKKSAHLTAGSTSTAEKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSANLVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINKLQDLIDRKLSGEQPIKAVDLERAALDLIQLKFHEKHCFKHLSPDHQGKIQQLEEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQNSPQGLAGIYSKILNFISLHMTDLLRLTLYSDKFPGFNFVVNSYWSDVETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEIAGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRLSRWITDAITQSKGSNFSKPYTRNQLLIALHADIRKLDAHLPELQQLIIKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASHITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQELCKLNFQATQIDKLVELTNMVEDSIKLKDNSA
What is the function of this protein?
Required for normal Golgi morphology and function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 2, COG complex subunit 2, Component of oligomeric Golgi complex 2, LdlCp-related protein.
What is the protein family that this protein belongs to?
Belongs to the COG2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ZN503_MOUSE
Sequence: MSTAPSLSALRSSKHSGGGGGGGGGGGSGGGSADPAWTSALSGNCSGHGPGSSPAGSTKPFVHAVPPSDPLRQANRLPIKVLKMLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPSPSSKLSSVASNGGGAGGAGNGAGGDKDAKSGPLKLSDIGVEDKSSFKPYSKPGSDKKEPGGGGGGGGGGGGGGGVAAEKSGFRVPSATCQPFTPRTGSPSSSASACSPGGMLPSAGGGPEGKDDKKDPEAGGGGSSKGSGGASADGVPAGLGHGRISCGGGINVDVNQHSEGGPGGKALGSDCGGSSSSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPSVMTASLCRDPYCLSYHCASHLAGAAAASASCAHDPAAAAAALKSGYPLVYPTHPLHGVHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLRTHTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLALRSPHHALGLSSRYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ
What is the function of this protein?
May function as a transcriptional repressor.
What are the official names of this protein?
Zinc finger protein 503, Zinc finger protein Nolz-1.
What is the protein family that this protein belongs to?
Belongs to the Elbow/Noc family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR3_TRICV
Sequence: MGQKTHPLGFRLGITQEHRSAWYANFNQYANLLKEDNQIRTYLNKLAKTASISNIQINRNGLSDQIQLNIETGRPGVLVGENGTGIKTLLSNIKKILPPNRQLTINIIEVEKVNLNASLIGDLVVEQLEDRVAFRKAIRKAMQSALDENVNGIKIQVSGRLNGAEIARSEWIREGRVPLQTLRADIDYATKEAHTIYGVLGVKVWLFKSEILAK
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y285_MYCGE
Sequence: MAAILNVQRIQNNQVTEYTMSPVRNFANTKDVYFDAQLTNIESKIDSSRAQIHLTIALKYNTNLPDNIFQAHFSLGNWQSDKIQLQKAPDKKHDSLNSIKYFYAFLDVPRSALAKKEINRFSNVVARVLRISFRLQDQSEKGNWSDYHLFDTVASELYATVIKETINFGNMIKINALDGSKQLTSSQGSFKYSWTMYDYRNLEQLDEVRNLINISFDKPVQIVNVDVKIHYVPTKGRLQEIKQQGEFENNLDVNEKLKLNLIGNWNFDKHNKKLISDISGTGIFLPQGGYGSYEIMIGATVGNDFYTIIANNQFKYETPLDDLEQNDFFEVNYLPVYSTYNFSDLTQ
What are the official names of this protein?
Uncharacterized protein MG285.
Protein: THIC_ALKOO
Sequence: MKYTTQMDAARKGIITKEMEIVSKKENMDIEILREKMAKGQIVIPANKNHKSLDPEGIGSGLKTKINVNLGISRDCPNVDAELEKVKIAIDMKAEAIMDLSSFGKTEEFRQKLVNMSTAMIGTVPIYDAVGFYDKELKDITEKEFLDVVRKHGEDGVDFVTIHAGLNRDTVKTFKKNTRVTNIVSRGGSLLYAWMELNNKENPFYEYYDELLEICAAYDMTISLGDALRPGSIADGTDASQIAELMVLGELTKRAWEKNVQVIIEGPGHMKLNEIEANVILEKKLCHGAPFYVLGPLVTDIAPGYDHITSAIGGAIAASHGVDFLCYVTPAEHLRLPTLEDMKEGIIASKIAAHAGDLAKGVQGADEWDLKMSKARQKLDWEEMFSLSIDDEKARRYRKESSPEHEDSCTMCGKMCSMRNMNRIMEGKDINILRSED
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: MAK5_LODEL
Sequence: MVKTVANGKKKPQKVVKKQQKTQKKHNQQKLQKRNTPTLKQKLKKESKIVKINELAWKPVEIPDNFGDFGGFYGLEEIDGVDVEMVDGKPQFVVKGEEGEKSVSNENTTTNELEDGDDIEVDEGEEIAQQEQENSDNDELIEEDAEEVEEQQQHGEKELEEEEFTGFGDDIAKEEKDSDGAKKKLNSSEDIDELKYNAFANLDLPLPNDDEIDLPEWGEDKIETCLSPYILNGLSNMKFTTPTPIQKRTIPLALEGKDVIGKATTGSGKTLAYGIPILEKYIQSLDTVKRKVREKVVNHPTGIIFAPTRELAHQVVDHLNKIAQYSPLSTKGIVSVTGGLSIQKQERLLSFGPGIIVATPGRMLELCQNDQELVKRLSMTDIIVLDEADRLLQDGHFEEFEKILELFNKNRPKNDKSIEWKWQTLVFSATFSRDLFGKLDKQQKQKSVKGNGKALNKADSGNSLVQNDEIIELLREKLRFKDKAPSLVDANPKEIVSGQITEALVECGPLERDLYLYYFLLMYKGSTLVFANSIDSVKRLVPLLNNLNIPAFAIHSSMIQKQRLRSLERFKDASEKNQTAVLVASDVAARGLDIPNIDHVAHYHLPRSADVYIHRSGRTARAGKEGVSVMFCSPQEASGPLRKLRKLVASNAANNKNQKINVHSDVKLLPVEMDLVSQLRPRVELAGRLADSNISSTATRKENSWVKQAAEELGVEDLHDLDEFEDDIIKKQRKRQESKRLDKNEQKRLRFELRELLANPIRKNNRRSYLTSGLQNLAHLMVQGTHHEDVLGHEKVKALKDLQKNGSKIKPVKGDDKMKRIAKVNQRKQAKKDAKKDAKQKRQELRHGHSNKSEE
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase MAK5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MIAB_BORA1
Sequence: MHETTLKREGASTPSNPTPSTHAAGSGKIYIRTFGCQMNEYDSDKMVDVLREDQGLEMTDNPEEADVILFNTCSVREKAQEKVFSDLGRVQHLKKLNPNLVIGVGGCVASQEGAAIVKRAPYVDVVFGPQTLHRLPELIRRRRDEGVSQVDISFPEIEKFDNMPPSRVEGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFEDVLTEVADLADQGVREVTLLGQNVNAYRGRIEGSDEIADFAMLLEYVHEIPGIERIRYTTSHPKEMTQRMVEAYARLPKLVSFLHLPVQAGSDRVLAAMKRGYTALEFKSVVRKLRAARPNLTLSSDFIVGFPGETEEDFQKTMKLIADVGFDTSFSFVYSRRPGTPAADLQDDTPQDVKLKRLQQLQALINEQAAAIAQSMVGTRQRLLVEGPSRRDPNELMGRTENNRIVNFEGPSRLIGNMVDVIITHAFTNSLRGRVAGTEESDQGAA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPSL_BACSU
Sequence: MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYPGVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKGVAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR
What are the official names of this protein?
Spore coat polysaccharide biosynthesis protein SpsL.
What is the protein family that this protein belongs to?
To dTDP-4-dehydrorhamnose reductase.
Protein: ISPE_SYNJB
Sequence: MQACTLIARAKINLYLEILGSRPDGYSEVAMVLQSIHLADRLQLKSRPHGIHLTCDRPEVPTDARNLAYQAAELLQKECHSAAGVEIHIEKHIPVAAGLAGGSADAAAVLVGLNQLWGLGLTVGELQSLAARLGSDIPFCIQGGTQLATGRGEVLEPLADWEGIPVLLAKPKHLGVSTAWAYQAFRSRREILGATAPSEPALPTLPQALAALSRQDPPALARSLRNDLEQVVLPEYAIVGELRQALLSAGALGSLMSGSGPTVFGIMPSLELAAQARDTLRRQFQDVEFWVTQFAPTGILLQPDPCSLSPS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RL6_BURPS
Sequence: MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQAVNPLVNVANNDGTLNLSPVDDSREANALSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGIKAETPTQTEIVIKGIDKQKVGQVAAEVRGYRPPEPYKGKGVRYADEVVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: KAD_SYNS3
Sequence: MKQRLLFLGPPGAGKGTQAALLCDRHGLRHLSTGDLLRAEVSAGSALGQEAESVMNRGELVSDSLVLAIVKAQLGALNGQGWLLDGFPRNVAQAEALDPLLQELNQPIEAVVLLELDDAVLIERLLSRGRDDDNEAVIRNRLVVYADKTEPLIEHYRQRGLLQSVEAHGSIEAITERIEGVLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_SHIDS
Sequence: MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPVEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFAPDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHQAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CEBP1_CAEEL
Sequence: MYSKLNYSHQKGDQALKHPHLVRLQQSEVRGFTDMPNNGASTSSAGSFARQDSLTIAASLQQRDRERHPVDFMETELDLGDYLQVLHDLDVPTDNVDFDDAELQKCNILYDGEHPYEQPELNGYERHVAYGTGYRVPGDYDQDGYKMNCEVKAETPDFGATKTRRAVKRPVPYDDYQKEYSEESSDMTDNDGSVDDSYFEPKSKKTKSAGLENFKPQTRARKYKLKADEEKAEPTYKLKRARNNDAVRKSRKKAKELQDKKEAEHDKMKRRIAELEGLLQSERDARRRDQDTLEQLLRNKGPMKEQRMPQRHILENFNK
What is the function of this protein?
Transcription factor (By similarity).  Binds to promoter regions of target genes, perhaps at the motif 5'-[AGCT]TT[AGT][TC]GAAA[ACT]-3' (PubMed:27927209).  Modulates expression of genes involved in development and in stress responses, including those regulating the p38/MAPK signaling pathways such as MAPKK sek-1 and phosphatase vhp-1 (PubMed:27927209, PubMed:34407394).  Involved in innate immunity (PubMed:27927200, PubMed:28662060, PubMed:34407394).  Plays a role in repressing the response to infection by the Gram-negative bacterium P. aeruginosa, perhaps acting independently of the pmk-1 or pmk-3 p38/MAPK pathways (PubMed:27927200).  However, also plays a protective role in the response to infection by P. aeruginosa (PubMed:28662060).  Required in axonal regrowth following injury and synaptogenesis (PubMed:19737525, PubMed:31417366, PubMed:26484536).  Following axon injury, in concert with transcription factor ets-4, activates expression of receptor tyrosine kinase svh-2 (PubMed:26484536).  May function downstream of the Ca2+-activated p38/MAPK pathway to promote axon regeneration (PubMed:26484536).  Plays a role in modulating polymerization of neuronal microtubules (PubMed:21368137).  Involved in modulating lipid homeostasis (PubMed:31851340).
What are the official names of this protein?
CCAAT/enhancer-binding protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. C/EBP subfamily.
What are the subcellular locations of this protein?
Synapse. Cytoplasm. Nucleus. Cell projection, axon. Note=Localization to nucleus dependent partially upon importin ima-3.