PharMolix/UniProtQA huggingface dataset:
Protein: COX1_PHOVI
Sequence: MFMNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYMLDDTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVMLMVFMIWEAFASKREVAAVELTTTNIEWLHGCPPPYHTFEEPTYVVLK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UREG_BURMS
Sequence: MNAPRFAAPARRTKKLPPLRVGIGGPVGSGKTTLLEMLCKGMRERYDLVAITNDIYTKEDQRLLTIAGALPEARIMGVETGGCPHTAIREDASINLEAVERMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLEVMASDTRKMRGERPYVMCNLKALDGVADVIAFIENKGLLTV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA2_YEAS7
Sequence: MSLPATFDLTPEDAQLLLAANTHLGARNVQVHQEPYVFNARPDGVHVINVGKTWEKLVLAARIIAAIPNPEDVVAISSRTYGQRAVLKFAAHTGATPIAGRFTPGSFTNYITRSFKEPRLVIVTDPRLDAQAIKEASYVNIPVIALTDLDSPSEFVDVAIPCNNRGKHSIGLIWYLLAREVLRLRGALVDRTQPWSIMPDLYFYRNPEEVEQVAEEAAAAEEGEEEEVKEEVTEGQAEATEWAEENADNVEW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0-B, Nucleic acid-binding protein NAB1B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PSBB_ORYSA
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSISGGTVTNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLAGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQAVNPAWGAEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSDGLAENLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDEEGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRSQLGEIFELDRATLKSDGVFRSSPRGWFTFGHATFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGTFQKVGDPTTRRQPV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HRCA_BIFLS
Sequence: MTQSRRMLVLRAVVEDYIRSQEPVGSTSLTRDHDLGVSSATIRNDMAALEDEGYLIQPHTSAGRVPTEKGYRYFVDRLATVVPLSEAQRRGINSFLSGSVSLKDALQRSARLLSEITGQVAVVTSPSLAKATLRHVEMVPVAMTTLLAVVITDTGRVAQHGLTIASMPAVDEINRLSNTVNEQCVGLSLSKSAETVRSIAASAGYESVRGVADALADAFESMALDERANELYMSGTSHLAHSRSLTDLAPLFDALEEQVVLMKLMSNLSEETNASGVGVAIGSEMHTPGLLHASVVSSGYGRSGEAGEPAGNDPVGEPETESETESQTNDMEPIAFVGSIGPTHMDYAATMAAVRAVARYLTAFLSEGRTQD
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: DPOL_PBCV1
Sequence: MTDITIFPTDWRAEDVVPDKGESFFRINIFGKTAEGKTVCVQTKFTPYFLLEVPESWSPARTNLFITETAMKYDAVRPMCLSTKRKNMWGFDGGKMRNMVQFVFKTQAQLRKAKYRLKDQYQIYESSVDPIIRVFHLRNINPADWIRVSKAYPAQTRISNSDIEVETSFQHLGPVEDKTVPPLVIASWDIETYSKDRKFPLAENPTDYCIQIATTFQKYGEPEPYRRVVVCYKQTAPVEGVEIISCLEESDVMNTWMKILQDEKTDVSIGYNTWQYDLRYVHGRTQMCVDDMTGEDKVKLSNLGRLLSGGGEVVERDLSSNAFGQNKFFLLDMPGVMQIDLLQWFRKNRNLESYSLNNVSKLYLGDQKNDLPAMQIFEKFEGNAEDRAIIAAYAAKDTDLPLKLLKKMAILEDLTEMANAVKVPVDYINFRGQQIRAFSCLVGKARQMNYAIPDDKAWATEGKYEGATVLDAKKGAYFTPIAALDFASLYPSIIRAHNMSPETLVMEKRFENVPGVEYYEIETGLGKFKYAQKNDETGEGQGVVPALLDDLAKFRKLAKKHMAEAKRNGDDFKEALYDAQQRSFKVVMNSVYGFLGASKGFIPCVPIAASVTATGRKMIEHTAKRAVELLPGSEVIYGDTDSVMVKMKLPDDKVHDMDEQFKMAKWLAGEITKDFRAPNDLEFEKIYYPYILYSKKRYAAVKFEEPDEKGKVDVKGLALVRRDFSPITRDILKESLDTILYKKDTPTAVSETLERIRKVLDNEYPMEKFMMSKLLKTGYKNECQPHLHVANKIYERTGFPVPSGARVPFVYIEDKKNPDIKQSFKAEDPTFAQDNGLIVDRLFYIEHQLLKPICSLFEPLLDDPEKEIFGHRLIKEKIENLKNVFKADLKVAKRVKKNIANNQREITSFFKKK
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase potentially exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: SYC_BRUA2
Sequence: MPDTTPQLRLYNTLTRTKEAFAPIDAKNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHVYGAQHVTYARNITDVDDKINARAARDYPDLPFNEAIRKVTESTNAQFQADVTALGNLQPTVQPRATEHMDEMRAMIDRLVQRGVAYVAQDHVLFSPSAMNARKGPRYGALARRSLDEMLAGARVDVASYKRDEMDFVLWKPSKKGEPGWPSPAGIETLGRPGWHIECSAMSMAKLLEPFGGGLKCDDPERNQFDIHGGGIDLVFPHHENEIAQSCCALGTERMANIWMHNGFLQVEGQKMSKSLGNFITIRDVLNDGLPQLGEWGDNTVRDHWAGLAARLSMLQTHYREPINWTAQRLAESADELHRWYGLLRDEGFGAPEKLSHASAVAAALCDDLNSWAAITALRQAFKVRDVAALGEGMALMGLLDPYFVTASDVPIFARADVDASAIAARIAERLNFINAKNWAEADRIRDELLQEGVQLKDSKDPATGERITTWDVVG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIPK_CAEEL
Sequence: MPKRKNSGQSTDLNSRSPKTIDEALRILAPPQALLVQSQLNLTAPANPFSIQKAPGTSSDNEQRAPKRRADEEAVNAVPKNLLTTSSTFARAVIPAAPAISSANNKMAPQSVTATAKTTTNRGKVSGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRKPGPAMATPYRAANVATPITPVEKPPAPKLQQPMIAVLPQLNQIAATNIPPVPTQPDLTNLMHHYSQMAAATGSAATAAQFFYQPLPPAPLFQYAQLHHPFAARPPHFLSLATPSHMVPQFVPVPIMDPSMLQGQWPPGAAQQFAVLANDIMRVPAPQGINQMFASTPQTFSLPQFLSSSIPSATTAFNGNAPNIPFPEENSSWALGTAAQQQQQQAQRAQSMINGNVKVKPLAAQPKKNSPAPSVITLSSDEDSNGAGSSNSGSTTRTGAVNPVRNDTLPMGNTIKTEDILVPPTTFDGQLPNLQYFPGSHLFDPKTVAGLLPNPFLDTSHIPRAFN
What is the function of this protein?
Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood (PubMed:23904186).  Plays a role in the development/differentiation of gonadal distal tip cells (PubMed:23904186).  Required for normal lifespan in a pha-4 and mxl-2-dependent manner (PubMed:26791749, PubMed:29036198, PubMed:36173858).  Also contributes to survival following heat or oxidative stress (PubMed:26791749).  Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock (PubMed:29036198).  Also required for hormetic extension of longevity in response to heat stress (PubMed:29036198).  Provides protection against polyglutamine aggregate formation and associated locomotory toxicity (PubMed:29036198).  Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression (PubMed:29036198).
What are the official names of this protein?
Homeodomain-interacting protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
Protein: GANA_ASPTN
Sequence: MLLSFLPLLPLATAALTYRGADISSLLIEEDAGIAYKNLNGQTQALESILADNGVNSIRQRLWVNPSDGSYDLDYNLKLAKRAKAAGMSVYLDLHYSDTWADPSHQTTPAGWSTDDIGTLAWQVYNYTKEVCDTFAANDIALEMVSIGNEIRNGLLWPLGATDSYPNIARLLHSGAWGVKDSALATTPQILLHLDNGWDWAAQKYFYDTVLAAGSELTSADFDLIGVSYYPFYNADATLSALKTSLGNLASAYGKKVLVVETNWPVACPNPEYQFPADLADIPFSVDGQSTFLRRLGEVVAGTDGGAGVYYWEPAWTKNAGLGSSCQDNLLVDYNTDQVRASISALGGI
What is the function of this protein?
Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.
What are the official names of this protein?
Probable arabinogalactan endo-beta-1,4-galactanase A, Endo-1,4-beta-galactanase A, Galactanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLP1_POPEU
Sequence: ITAGFISSSANTVYVKKGDVMVFPR
What are the official names of this protein?
Germin-like protein.
What is the protein family that this protein belongs to?
Belongs to the germin family.
Protein: TAZR_ASPTN
Sequence: MSPSLNEPERLNRQAQGLACNECRARKLRCDRVRPTCGTCESLGVTCTPNSVRQPRGPRKGYLKTLQSRISALERQWNGQQKAAGGSPGESPPCSEGGQTLRAVSESTSDGVHDEDHANGARPPSSQSSIEQPILQPTVSLDGISALHGFAPVNSPFAFALPGTDPSKTVDLFSHMECFPSMPTKLDPRAYVPQQLTPNSTMSNGQFDLPTDLSVTSEFQLPELMKADLSHLYFDRVHPFAPILNKRRYFARAARPVSEQGAMTCLQHAMWTLAAWLGSQFKHIQKDLYIYTRGLLEKWELNMHPGNPPIELAQARLFLAIYEIMQVNYERGWLSAGRCFRLIQLMKLHEIDVPDGISESGISFGEIEERRRTFWMAYSLDRFINLINKMPLTLNEQVIFTRLPAPEGAFQRERPVQTQFLSEFMAGDDDLQIVSPFSACIVVMTISGRCLSHQQQCMVERAYGGMPQDFITRHQWLEGILMSKGKAIVDCISNDLDDELTDPMLLFTNMAAHATTLLLGMTMQTGLCNYESLISGFEERATEAAQKILHLCQRLNECGYFKVHPFTPIPLVFCAEWAQGRKNQNPAFEPLHNSMLCSLRDLSVVNMLAETCLARLNDSNPQMETDMSKSQS
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of azaterrilone A and other azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities.
What are the official names of this protein?
Transcription factor tazR, Azaphilone biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS20_ACIC5
Sequence: MANHVSSLKRARQTVRKTAVNRANKSRVRGSLRSLREAIQKGDVKAAQEQYKATASALDKSVQKGILHANTASRYKSRLNARVKALATQAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ACMA_LACLC
Sequence: MPVSRVKVKNRHLKKKTKKPLAFYKPTTKFVGAVLIAGTLTTTHELLLQQTSPMVQAATNSSEAFIESIAASAKPVADANGLYPSVMIAQAILESNWGSSQLSRAPYYNLFGIQGTYQGKSVVFKTQEYLNGKWVTKDMPFRVYPSFNQSFQDNTYVLKTTNFGNGPYYAKAWRANAATYQDATAALTGKYATDPSYGASLNRIISQYNLTRFDGASSAGNTNSGGSTTTNTNNNSGTNSSSTTYTVKSGDTLWGISQRYGISVAQIQSANNLKSTIIYIGQKLLLTGSASSTNSGGSNNSASTTPTTSVTPAKPASQTSVKVKSGDTLWALSVKYKTSIAQLKSWNHLSSDTIYIGQNLIVSQSAATSNPSTGSGSTATNNSNSTSSNSNASIHKVVKGDTLWGLSQKSGSPIASIKAWNHLSSDTILIGQYLRIK
What is the function of this protein?
Hydrolyzes the cell wall of L. lactis and M. lysodeikticus.  Required for cell separation during growth.
What are the official names of this protein?
Probable N-acetylmuramidase, Autolysin, Lysozyme, Peptidoglycan hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 73 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_ECOSE
Sequence: MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFIRISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGREGPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRAARA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KDPA_ECOUT
Sequence: MAAQGFLLIATFLLVFMVLARPLGSGLARLINDIPLPGTTGVERVLFSALGVSDREMNWKQYLSAILGLNILGLAVLFFMLLGQHYLPLNPQQLPGLSWDLALNTAVSFVTNTNWQSYSGETTLSYFSQMAGLTVQNFLSAASGIAVIFALIRAFTRQSMNTLGNAWVDLLRITLWVLTPVALLIALFFIQQGALQNFLPYQAVTTIEGAQQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPTALTNFVQMLAIFLIPTALCFAFGEVAGDRRQGRMLLWAMSVIFVICVGVVMWAEVQGNPHLLALGADSSINMEGKESRFGVLVSSLFAVVTTAASCGAVIAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMMLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKLTALAILVTPTLVLMGAALAMMTDAGRSAMLNPGPHGFSEVLYAVSSAANNNGSAFAGLSANSPFWNCLLALCMFVGRFGVIIPVMAIAGSLVSKKSQPASSGTLPTHGPLFVGLLIGTVLLVGALTFIPALALGPVAEYLS
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLYA_EDWI9
Sequence: MLKREMNIADYDTELWQAMQQEVTRQEQHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCQYVDQVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNVVPYGIDAHGRIDYDDLAAQAQRHRPKMIIGGFSAYSGVVDWARMREIANSIGAYLFVDMAHVAGLVAAGVYPNPIPHAHVVTTTTHKTLAGPRGGLILAKGLDETMYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPEFTRYQQQVAKNAKAMVDVFLQRGYKVVSGGTENHLFLLDLVDRQITGKEADAALGHANITVNKNSVPNDPQSPFVTSGIRIGTPAITRRGFKEAESRELAGWMCDVLDNIHDEATIACTKQKVLALCERLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_JASNU
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DPOL_BPMD2
Sequence: MIELRHEVQGDLVTINVVEHPEDLDGFRDFIRAHQNCLAVDTETTGLDIYSADFRCRLVQFGTQTESWVLPIEDLEMLGREEVHEALDVLNKIVMQNASYDLQVLDRCFGIKMESLWPKILDTQILAKLVDPRPFGAGGFGHSLEELIAEFISKEQAENVKGLMAKLAKEHKTTKAKIWSTIDLYHPEYLTYAGMDTVFTARICSALAPLVPDVSRPLVPYEHKISEICSYIDRRGFLLDVEYSQQLADKWLGEQQVWEAVLLNEYGIEKVNATEDVAEAFEELGHKFTAFTDSGKRKVDKGFYADMIAAGGEKAHLAEMVQEAKKLGKWRTSWVQTFLDTRDSEDRCHTFVNPLQARTSRMSITGIPAQTLPASDWTVRRCFLADPGHVMASIDYQAQELRVLAALSGDRTMIQAFKDGADLHLMTARAAFGDHITKDDPERKYAKTVNFGRVYGGGANTVAEQTGISIETAKQVVDGFDKAYPGVTRYSRKLANEAKRNGYIINPMGRRLPVDRSRTYSALNYQIQSTSRDVTCKALIRLHEAGFTPYLRLPIHDEIVASLPAEKANWGAREIARLMAEEMGPVLIGTDPEVGKRSWGSLYGADY
What is the function of this protein?
Replicates viral genomic DNA.  This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: UGPC_YERPN
Sequence: MACLKLQAVTKSYDGVTPVIKQIDLDVADGEFIVMVGPSGCGKSTLLRMVAGLERTTTGDIYIGDQRVTDLEPKDRGIAMVFQNYVLYPHMNVFDNMAYGLKIRGFGKEQIRQRVDEAARILELQPLLKRKPRELSGGQRQRVAMGRAIVREPAVFLFDEPLSNLDAKLRVQMRLELQQLHRRLKTTSLYVTHDQVEAMTLAQRVIVMNKGVAEQIGTPSEVYKRPASLFVASFIGSPAMNLLDGTVSPDGRTFILSDGLTLPLEIPQPQWGGRRLTLGIRPEHIQQTTSAQGVPMNLLTLELLGADNLAHGLWGGQSIIARLSHEEMPVAGSTLHLYLPPAALHFFDTDSGLRIEP
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
sn-glycerol-3-phosphate import ATP-binding protein UgpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IRC6_YEAS1
Sequence: MVLQYPQNKILVLSDHPHNFSKTQFLQDLFHCSSTGISIVKDQTWENRYYKVHFDLYIDSCKDIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLHQFMIAAHRNTFVVLVNVNEEVEQDEIDELNEIWSNAFTNVIEFVNWKRSKPTVNHNDYGEKLGLDRIQEIIDTHDWLNCEVLPATKIREEIPNEMPLEQIIRNLQSARLKYKSIENSSEADAFANEMADELSRYL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: PROB_CHESB
Sequence: MSGISLSSYRRVTVKIGSALLVDRAAGLKREWLAALVDDIARLMSAGTEVLVVSSGAIALGRTVLGLGKRTLRLEESQAAAAVGQIALAGAWSGELGRHGLISGQVLVTLGDTEERRRYLNARATISTLLKMKAVPVINENDTVATSEIRYGDNDRLAARVATMMGGDLLILLSDVDGLYTAPPERDPAAKFIPVVDAITPEIMAMGGAAASELSRGGMRTKLDAGRIATAAGTAMIIASGKERGPLSAIERGARATLFKPSPTPVRAYKTWIAGQLEPAGRIGIDDGALRALLQGKSLLPAGVRRVEGVFSRGDTVAIVDSAGREIGRGLVAYDAADAVKIAGLKTGDIAGILGYEARAAMVHRDDLVLSGPTGELMDRKVEGIDVAGA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PD_ECOL6
Sequence: MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFSRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMITRDGRSWNEFE
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: BRE1B_MOUSE
Sequence: MSGLSNKRAAGDGGSGPPEKKMNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSGTEVPGCQEGLTRDVIPRPDPGTSDLREPLPVQFRAPLSEPALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARVRTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCIPTLSHPDDPGLNALAPGKEDSGPGPGGTPDCKKEMALLAGATSATSSIKKEELVSSEDDAQALTPVTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS
What is the function of this protein?
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1).  H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).  It thereby plays a central role in histone code and gene regulation.  The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.  Required for transcriptional activation of Hox genes.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1B, BRE1-B, RING finger protein 40, RING-type E3 ubiquitin transferase BRE1B.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.