PharMolix/UniProtQA huggingface dataset:
Protein: NS1_I68A0
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLGLNIEAATRVGKQIVERILKEESDEALKMTMASAPASRYLTDMTIEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNVMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNENGRPPLTPKQKRKMARTVRSKVRRDKMAD
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: SCGR5_HUMAN
Sequence: MGCCGCGGCGGCGGGCGGGCGSCTTCRCYRVGCCSSCCPCCRGCCGGCCSTPVICCCRRTCCSCGCGCGKGCCQQKGCCQKQCCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Small cysteine and glycine repeat-containing protein 5, Keratin-associated protein 28-5.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 28 family.
Protein: RPOI_METJA
Sequence: MKGMDEYEKIINDLNTINSKAKFIGIKIIMVRRIIDMHKDNDKLIKKVLEGIKNTDLYDLVLNACPELKGERIKDVYFKKNDYFNVIKKTMSSENTVLKNVLINDESPP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit I.
Protein: RLMG_YERP3
Sequence: MSQLDLGTQSLELERFPPQENSNTLQAWEAADEYLLQNIDLSQIDGRPVLVFNDQFGTLACALHAYRPFSSSDSYMSQLATAHNLRLNHLDESAVTLLSSVDDLPEAPKLVVIKIPKALALLEHQLRALRRVVAPDTVIIAGAKSRDVHNSTLQLFEKILGPTKTTLAWKKARLIHCEVADIPLADAPETIDWPLPNTDYIIHNHANVFSRNNLDIGARFFMEILPYDVTGKIADLGCGNGVVGLIALEQNPLAEMLFVDESYMAVASSELNITVNRPQDLSRCEFMVSHGLAGVERESLQLVLCNPPFHQQHAVSDHVAWQMFCDAKRCLKAGGELMIVGNRHLDYFHKLKRLFGNCETLDSNQKFMVLKSVKQASSRSEGGGSGSLDMSYSDF
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_CUCSA
Sequence: MLGGGNERMSTIPAFNQIQFEGFCRFIDHGLTEELSKFPKIEDTDQEIEFQLFVETYKLVEPLIKERDAVYESLTYSSELYVSAGLIWKTRRDMQEQTIFIGNIPLMNSLGTSIVNGLYRIVISQILQSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWARVSRKQKISILVLSSAMGSNLREILENVCYPEIFLSFLNDKEKKKIGSKENAILEFYQQFSCVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNLNQRLNLDIPENNTFLLQRDILAAADHLIGLKFGMGTLDDMNHLKNKRIRSVADLLQDQFGLALVRLENMVRGTICGAIRHKLIPTPQNLVTSTPLTTTFESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTASFRIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARIGHWGSLETPFYEISERSKKVRMLYLSPSRDEYYMVATGNSLALNPGIQEEQIVPARYRQEFLTIEWEQVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVARDSGVAAIAEHGGKIIYTDTDKIIFSGNGYTRRIPLVMYQRSNKNTCMQQKSQVHQGKCIKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLIYEDIYTSFHIRKYEIQTHVTSHGPERITNEIPHLEARLLCNLDKNGIVMLGSWVETGDILVGKLTPQMAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIVSKILPREDMPYLQNGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIVPFDERYEQEASRKLVFSELYEASKQTASPWVFEPEYPGKSRIFDGRTGNPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRAKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDTPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EX7S_PSEAB
Sequence: MARKKTLDFEQSLTELQTLVERLESGELSLEESLGAFEQGIRLTRECQTSLSQAEQKVQILLERDGELSEAPFDAEGDEA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFTR_SALPA
Sequence: MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQHGIFPWFSPGDPILWWSPDPRAVLWPEKFHLSRSMKRFHNASPYRVTLNYAFDRVIDGCANHRDEGTWITRGIEEAYRRLHELGHAHSIEVWRDQELVGGMYGVSQGALFCGESMFSRQENASKTALLVFCAEFIRHGGKLIDCQVLNSHTASLGAIEIPRRDYLDHLAGLRQQPLASRFWVPRTLFLPRK
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAE_SALPK
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGSGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMAKAGMVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: ANX11_DROME
Sequence: MYPFGSGMPSHPPTSTNHHEPPRAPFGAGWVPPMQQNSPYPPPSQPHPHSQPSSQMHPQQHQQYPGGAPAPYPPMSAPYPSAAPSYPPYPTSNPYPAQYAPPAHNHYQQPSVSNSPYPADRGYTPAMTAGYDAGYGYGNGQGHGQGHGHGQGHGHGHGQGHEYGHGYGQGYGHGQGHGNGQGHAHRSLPAHREGTPTVVPAANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDIKSETSGNFEKLLVGLLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYGAHLESELKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILCQRNYQQLKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGTNDTQLIRVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVGEQRSS
What are the official names of this protein?
Annexin B11.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
Protein: NFCP_GONTE
Sequence: MSVIAKQMTYKVYMSGTVNGHYFEVQGDGKGKPYEGEQTVKLTVTKGGPLPFAWDILSPQSQYGSIPFTKYPEDIPDYVKQSFPEGYTWERIMNFEDGAVCTVSNDSSIQGNCFIYNVKFSGLNFPPNGPVMQKKTQGWEPNTERLFARDGMLIGNNFMALKLEGGGHYLCEFKSTYKAKKPVKMPGYHYVDRKLDVTNHNIDYTSVEQCEISIARKPVVA
What is the function of this protein?
Non-fluorescent pigment protein that is lilac in color.
What are the official names of this protein?
GFP-like non-fluorescent chromoprotein, gtCP.
What is the protein family that this protein belongs to?
Belongs to the GFP family.
Protein: SYGB_NOSS1
Sequence: MPGFLLEVGTEELPASFLGGAIAQWRSRIPQSLAANSLTSESVEVYGTPRRLAVLITGLPSQQPDREEEIKGPPAQAAFKDGQPTPAAVGFAKKQGVELEALEVRPTDKGEFVFIQKKTPGRPVADILTELVPQWIYSLEGKRLMRWGDGDVRFSRPIRWLVALLDEAILPLELVNGSLTVKSDRISYGHRVLHPAPITIQKAGDYVNTLRDGYVTVNAKERTTTIKEQVAATVQKLGGYTEIYPDLLEEVTNLVEWPSPVVGKFEEEFLNLPTEVTTTVMVSHQRYFPVFKTGDHKELLPYFITVSNGDPTKSEVIAVGNERVIRARLADGQFFYKTDLSKSLESYLPQLETVTFQEDLGSLRGKVERIVKVAAQISSQLQLGEGDRQNNQRAALLCKADLVTQMVFEFPELQGIMGQKYAVASGESPEVSTAIVEHYLPRGADDILPQTLTGQVVGLADRLDTLVSIFGLGLIPTGSSDPFALRRAANAVVNITWAANLQINLASLLAQTVAEFAAQYNKDQAPLITALNEFFLQRIRTLLQEEKQIDYDLVNAVLGENDPEYTERALQDLLDVRDRALYLQQIRRDGTLDKIYETVNRSTRLAAQGDLDTQQLDPTSVVRPELFQKPSESDFYDALVKLVPQTQAAQESRNYQLLVAGLVEIAPTVSNFFDGADSVLVIDPDPEIKRNRLNILGLLRNHARVLADFGAIVKNL
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BNPL1_CROOA
Sequence: SKRLSNGCFGLKLDRIGAMSGLGCWRLINESK
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity in rats.
What are the official names of this protein?
Natriuretic peptide Coa_NP1.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family. Snake NP subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RF1_ERYLH
Sequence: MTIPATRLDQIANRFAELEARMASGTLEGEEFVQASRDYAELEPVAKVAAEVKAMREEIGGLEEMLADPEMKAMAQEELAAIREALPEKERQLAIAMLPKDSADNKPAMLEIRAGTGGDEAALFAGDLYRMYERFAGEQGWKVEPVSMNASEVGGFKEIVANVSGTGVFAKLKFESGVHRVQRVPETESGGRIHTSAATVAVLPEPDEVDVQIDDKDLKIDIYRASGAGGQHVNTTDSAVRITHLPTGIVVQQQDERSQHKNKAKAMQVLRTRLYDHLREQSQGEEAAARKAMVGSGDRSERIRTYNFPQGRVTDHRIGLTLHKLDEIIAGPGLGELVGALIAEDEAKRLAALSE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBAB_SALCH
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RDO1_USTMD
Sequence: MLRSSQARSVVRSSQWATTARVHQLELPSGWKPSALGVAPWQQRQQRQLSVRSLDHLVITCHDMDKTIDFYTRLGMSVVQFGQGRKALEFGSQKINLHQKGKEFEPKALVPQPGSQDLCFVIHDSIADAQKHLQEHGIQVVEGPVKRTGAVGPILSIYVRDPDNNLIELSSYQDAK
What is the function of this protein?
Glyoxalase domain-containing protein; part of the gene cluster that mediates the biosynthesis of itaconic acid and 2-hydroxyparaconate (PubMed:26639528, PubMed:27750034).  Cis-aconitate is secreted by the mitochondrial tricarboxylate transporter MTT1.  In the cytosol cis-aconitate is converted into trans-aconitate via isomerization by the aconitate-delta-isomerase ADI1 (PubMed:26639528).  Decarboxylation of trans-aconitate by the trans-aconitate decarboxylase TAD1 then leads then to the production of itaconic acid (PubMed:26639528).  The cytochrome P450 monooxygenase CYP3 further converts itaconate to 2-hydroxyparaconate via oxidation of the double bond, leading to a transient epoxide, which can subsequently be lactonized to produce 2-hydroxyparaconate (PubMed:27750034).  Secretion of itaconate and possibly 2-hydroxyparaconate into the medium is mediated by the major facilitator ITP1 (PubMed:26639528, PubMed:27750034).  The glyoxalase domain-containing protein RDO1 is not involved in the biosynthesis of itaconate and 2-hydroxyparaconate, however, it might play a role in the further conversion of 2-hydroxyparaconate to itatartarate (PubMed:27750034).
What are the official names of this protein?
Glyoxalase domain-containing protein RDO1, Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein RDO1, Putative ring-cleaving dioxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: PYRH_UREPA
Sequence: MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNIWRGSIAKELDMDRNLADNMGMMATIINGLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNGVDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.  Is also able to phosphorylate dUMP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRM2_PEA
Sequence: MDSRKAMLILGLLAMVLLISSEVSARELTEEVVEKSDEVNDAKYGGYGRGGGYHNGGGYHNGGGGYNGGGGYHNGGGGYNGGGGYHNGGGGYHNGGGGYNGGGGYHNGGGGYHGGGGHGGHGGASNNGN
What are the official names of this protein?
Dormancy-associated protein 2, PsDRM2.
What is the protein family that this protein belongs to?
Belongs to the DRM1/ARP family.
Protein: DRR4_PEA
Sequence: MGVFNFEEEATSIVAPATLHKALVTDADILTPKVIDAIKSIEIVEGNGGPGTIKKLTFVEDGETKYVLHKVELVDDANWANNYSIVGGVGLPDTVEKISFEAKLSAGPNGGSIAKLSVKYYTKGDAIPSEEEIKNGKAKGEGIFKALEGYCVANPDYN
What are the official names of this protein?
Disease resistance response protein DRRG49-C.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: GCH4_STAAE
Sequence: MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVLVDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQNAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSKEISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTERAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RNH_NEIG1
Sequence: MDTPVYLYTDGACKGNPGAGGWGVLMRYGSREKELFGGEAQTTNNRMELTAVIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTAAKQPVKNDDLWQELDALVGQHQVSWTWVKGHAGHAENERADDLANRGAAQFS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEY1_CRYNJ
Sequence: MNQTPQIAQDLLKNPPQELQQLLNDPRTPDSARKAVQELQAPFVGPGTAGNKDGAKESPRLQIVNENQEFTKELSPYLAKWDLLDKGFAYDVVAVFGSQSTGKSTLLNRLFGTTFDVMDESKRQQTTKGIWMCPSQYSNTLVMDVEGTDGRERGEDQDFERKSALFSLASTEVLIVNLWEHQIGLYNGANMGLLKTVFEVNLGLFGGGGDNTKPKPQEKTLILFVIRDHVGATPMSNLTATLTQDMERIWDSLSKPAHLEDAVLSSYFDLSFAALPHKVLMPEKFEEAVLELRQRFTDRSREDYVFQPAYHKRIPADGVSFYMEGIWQQVLTNKDLDLPTQQELLAQFRCDEISTVVFEAFLASAKIVRRPVEAGSVVEGLGALMRDWLETALGKFDRDASRYHSAVYQRKRLDLLASLHASLSPLFLGQLKNLHKIETAKFSKDIVAGVKEPGYDFGVVVEEGKRRARERFLAGAKEVKVEETDWEYEHELALLDEDLKLIADKCRADETKKMVNAIERNVKRQILEPVEVAMSQPTKTMWDTVLKTYSDVIEAAEEAYLSKAKSYNCSDEENSTALASLRARAWLALRRKLEEQTSDSTVLTTLRTKFEDSFRYDEAGVPRVWRPEDDIEAAFRKAKDETLGLLPLFANIAPTEGSLLPELPPPEPSFDVESDPSPFDPSTAFTLLTATKLLSLESRFKRDADAAYVEAKRSMVSSVAQIPVWMYGVLVVLGWNEAMAVLFNPLYFAMLLVLAASGYIILQLGLAGPILQIASTVIREIRQMVVKKLREAFADVPEAQRILAQPVTASSSDEQERKGDLIKGEMLEK
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: SIAM_XENLA
Sequence: MTYEAEMEQIVSTALTLQDDYIKFTPRNQNMACHAEIIGIFHDIHPTVEIKEPHQDKSVLQETLVELYSVLGIPQEPQVSKTMKFEEPEQHKESSSTVTRSDSLVNSLQSTGLKRPFCEDEHREYKKPLIQAEDISPATSTRSRKRTIYSKEQTNFLQNQFDLNPYPDFVNRCRIAKITGIPEPRIQVWFQNRRARHLPRATTFHSPQGRKSPTSEGPRSFLSREAHYPDEWGQAPNPSNTQPYPN
What is the function of this protein?
Essential for Wnt/beta-catenin-mediated formation of the Spemann organizer and for induction of the organizer precursor, the Nieuwkoop center.  Acts as a transcriptional activator, cooperating with TGFbeta signals to induce a program of organizer-specific gene expression and to generate an organizer with both head- and trunk-inducing activity.  Activates the head organizer gene cer1 by acting synergistically with otx2 and mix-A/mix. 1 through the 5'-TAATCT-3' element of the cer1 promoter.  Also binds as a complex with lhx1/lim1 and mix-A/mix. 1 to the 3x 5'-TAAT-3' element of the cer1 promoter.  Required for subsequent dorsoventral axis formation in the embryo, dorsalizing ventral mesoderm and cooperating with t/bra to induce dorsal mesoderm.  Also involved in neural induction, inducing the cement gland and neural tissue in overlying ectoderm.  Later in development, has the second function of indirectly repressing ventral genes, probably by activating the expression of a transcriptional repressor.
What are the official names of this protein?
Homeobox protein siamois.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM3_STAAC
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NQRE_STUS1
Sequence: MEHYISLFVRAVFIENMALAFFLGMCTFIAISKKVETAIGLGIAVIVVQTITVPANNLIYTYLLKSGALAWAGLPEVDLSFLGLLSYIGVIAAIVQILEMTLDKYVPSLYNALGVFLPLITVNCAIMGGTLFMVERDYNLGESVVYGMGSGLSWALAIALLAGIREKLKYSDVPDGLQGLGITFITIGLMSLGFMSFSGVQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
Protein: TPD55_HUMAN
Sequence: MPHARTETSVGTYESHSTSELEDLTEPEQRELKTKLTKLEAEIVTLRHVLAAKERRCGELKRKLGLTALVGLRQNLSKSWLDVQVSNTYVKQKTSAALSTMGTLICRKLGGVKKSATFRSFEGLMGTIKSKVSGGKRAWP
What are the official names of this protein?
Tumor protein D55, hD55, Testis development protein NYD-SP25, Tumor protein D52-like 3.
What is the protein family that this protein belongs to?
Belongs to the TPD52 family.
Protein: RL19_METCA
Sequence: MNIVQQLESEWMSGKTIPAFGPGDTVVVQVKVKEGNRERLQAFEGVVIAKRNRGYNSAFTVRKVSHGEGVERVFQTYSPQVEEIQVKRRGDVRRAKLYYLRDRAGKAARIKEKI
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GCR_AOTNA
Sequence: MDSKESLTPGKEENPSSVLTQERGNVMDFSKILRGGATLKVSVSSTSLAAASQSDSKQQRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLQLLEESIANLNRSTSVPENPKSSASSSVSAAPKEKEFPKTHSDVSSEQQNLKGQTGTNGGNVKLYTADQSTFDILQDLEFSSGSPGKETNQSPWRSDLLIDENCLLSPLAGEEDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSSSNVTLPQVKTEKEDFIELCTPGVIKQEKLSTVYCQASFPGANVIGNKMSAISIHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPANKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSTVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASSNLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQLPKYSNGNIKKLLFHQK
What is the function of this protein?
Receptor for glucocorticoids (GC).  Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.  Affects inflammatory responses, cellular proliferation and differentiation in target tissues.  Involved in chromatin remodeling.  Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay.  Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.  Mediates glucocorticoid-induced apoptosis.  Promotes accurate chromosome segregation during mitosis.  May act as a tumor suppressor.  May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
What are the official names of this protein?
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus (By similarity). In the presence of NR1D1 shows a time- dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity).