PharMolix/UniProtQA huggingface dataset:
Protein: ORC2_HUMAN
Sequence: MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEEDDQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3.  Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation.  Also stabilizes ORC3.
What are the official names of this protein?
Origin recognition complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ORC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DXS_AZOSB
Sequence: MSPYPHLERIGSPADLRATERRELAQVASELRAFLIESVSKTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQTYGHKILTGRREAMSGLRHWGGISGFPRRCESEYDTFGTAHSSTSISAALGMAVAARDRGEDRRAIAVIGDGAMSAGMAFEALNNAGDMDANLLVILNDNEMSISPPVGALTKILARLMSGSTYNAARRVGEKVLGTVPPMAELARKVEEYAKGMIAPGTLFEEFGFHYYGPIDGHDLDALIPTLQNIRKLKGPQFLHVITKKGQGYKLAEADPILYHGVSKFDHTAGIQTGKSGGKLTYTQVFSDWLCDIAAADPRIVGITPAMREGSGLVEFAQRFPDRYYDVGIAEQHALTFAAGLACEGLKPVVAIYSTFLQRAYDQLIHDIALQNLPVVLAIDRGGLVGADGATHHGAFDLSFLACVPNLVVMAPADENECRQMLYTAVCHDGPTAVRYPRGGGSGVVPLEPMTALPIGKGEIRRHGTRIAVLAFGSMLGVALEVGEALDASVANMRFVKPLDEALIAELAANHALLVTVEENAVIGGAGSEVARFVDTLPQRPRVLRLGLPDRFIDHGDQAQLLASVGLDKTGILAAIEAVYPHNS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: ATPB_BUCA5
Sequence: MATGKIIQIIGAVVDVEFNQDSVPKIYNALEVKNKQYKLILEVQQQLGSGVVRTIAMGSSNGLKRGLIVTDLGHYIKVPVGEATLGRIINVLGETIDNKGALKNNQSDKIEYWEIHRSPPSYRDQASCREILETGIKVIDLICPFSKGGKVGLFGGAGVGKTVNMMELIRNIAVEHSGYSVFTGVGERTREGNDFYHEMNDSQVLDKVSLVYGQMNEPPGNRLRVAFTGLTIAEKFRDEGKDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGLLQERITSTKNGSITSVQAVYVPADDLTDPSPATTFAHLDSTVTLSRQIASLGIYPAIDPLNSTSRQLDPYIVGDEHYETALGVQSILQRYQELKDIIAILGMDELAEKDKLLVSRARKIQRFLSQPFFVAEVFTGFPGKYVSLKDNIRAFKGIIKGEFDDLPEQAFYMVGSIEEVIEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SC16B_CHICK
Sequence: MEPWDPPQLPPVRHSHAAGSGRAEGRHGTPPPWRPIISGPLPRPGSWDPGRDLHRPASQAESYESGHAFRAYSRQGYEDPHWQYPGAAYRDNHAYQSHQWQPTAWQGNRDVTQVKPHGKSTTYRDQHYYRGYHPNLAASPLGQDRSQTYDAYKEGSRRSWAGVSNLGEASGQPQQPSLLQQYRESGLSSSGYELSQYIRDGAEPNDTAFLGGWSPVQGGGPLESAVMAPHKFLQPHVPVCLGAGGQLVLVCPHRPTEGQLPLVELHSLEVILQGTTDQEELQAFPGPLAREDLHKVDVMTFCQQKIASSCDLSTQRGRDSALLWKLLVLLCRQNGSMVGSDVAELLMQDCRQQERYKRQEPAVGPVSLADEEWRQLGTLDLITGEVPPVVETQAQIVEKFTKLLYYGRKKDALVWAMRNQLWGHALFLSSKMDPRTYSWVLSGFTSTLATNDPLQTFFQLMSGRIPQAAQSCGDAKWGDWRPHLAVLLSNKVGDMELNHRAIVTMGDTLAGKGAVEAAHFCYLMADIPFGYFGVKADRMALLGSSHRQAFTQFATKEAIQRMEIFEYCQQLRHPTSFLLPFQVYKLLYASRLADHGLPAQALLYCEQIATVLLQQDPTSHPVLAQQLTKLAERLKLCDPLLLLEMPEQDPVLEPQWLLQLRTYCQHCQVQDDLAPEVALTQPEPWDTTATPGREMVHEQPHSDGPHDEQWHQPPVPLQGPDPHQDVSIPPLEVAVLGVGPISQEELCTEPSLQAVPTAGDAEEPQDAHGVQQPVLAELQELSTRARSASESSTASLEEDSQTSSDSPAEELEGTSEDKSFGFRWFGWFRSKPQKETSPKATTSGSPTPGLQDRRSPSPPGAVPSAQPPASPSPYRNPVSIDMKGPWDADGHEPLPGMVPLFNPAQVSQLAAARPTQPRLLSQRRYPNPL
What is the function of this protein?
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).  Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.  Involved in peroxisome biogenesis.  Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
What are the official names of this protein?
Protein transport protein Sec16B, Regucalcin gene promoter region-related protein p117, RGPR-p117, SEC16 homolog B.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Protein: WDR26_ARATH
Sequence: MGVVEDTEPPLKRAKRLADEPNGFSANSSVRGSSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIITRALYSLGYDKTGAMLEEESGISLHNSTIKLFLQQVKDGKWDQSVKTLHRIGFPDEKAVKAASFLLLEQKFLEFLKVEKIADALRTLRNEMAPLRINTKRVHELASSLISPSSFISHTTSTPGKESVNSRSKVLEELQTLLPASVIIPEKRLECLVENSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQIPSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHISLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYKGHKRSRFIIRSCFGGYKQAFIASGSEDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLHMLASASDDGTIRIWGLDRINQQNQKKKLVQGSSSNGVIHRCNGN
What is the function of this protein?
Acts as a component involved in the crosstalk regulation between light, hormone and abiotic stress response.
What are the official names of this protein?
WD repeat-containing protein 26 homolog, AtWDR26.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates predominantly in the form of large cytoplasmic complexes.
Protein: TMPS2_HUMAN
Sequence: MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
What is the function of this protein?
(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876).  The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site (PubMed:32703818).  Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876).  Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV).  Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
What are the official names of this protein?
Transmembrane protease serine 2, Serine protease 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Transmembrane protease serine 2 catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
Protein: TYSY_SHEON
Sequence: MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGEAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFDDFALSNYDPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIS_ECO24
Sequence: MLAFCRSSLKSKKYFIILLALAAIAGLGTHAAWSSNGLPRIDNKTLARLAQQHPVVVLFRHAERCDRSTNQCLSDKTGITVKGTQDARELGNAFSADIPDFDLYSSNTVRTIQSATWFSAGKKLTVDKRLLQCGNEIYSAIKDLQSKAPDKNIVIFTHNHCLTYIAKNKRDATFKPDYLDGLVMHVEKGKVYLDGEFVNH
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RISB_POLAQ
Sequence: MTNSNNDFVGVLEADLNGQDLRIGIVQARFNEEHCVALSTACITELLALGVTQADIKLVTVPGALEIPFALQKLAATGEFDGLVALGAVIRGETYHFELVSNESAAGITRISIDSGLPIANGVLTCETDEQASVRVNLKGADCAKAVVEMANLALALTPDFDIEVNAGEE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: HEM3_ECOLI
Sequence: MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TRUA_RHORT
Sequence: MVRYRLTVEYDGRGYCGWQRQDNGPTIQQSLEEAAFRLCGVATRVHGSGRTDSGVHALGQVAHLDLPRAYGAATVMKALNAHLRPQPIAVIDAAEVAEDFHARFSAEERSYRYRILNRIAPPTLDQGRVWWVARPMEAAIMDEAAQVLVGRHDFSSFRAAECQADSPVKTLSELRVTRVGDEIHVFARARSFLHHQVRNMVGTLALVGDGRWTADRLRAALEACDRSAAGPTAPPDGLYFLRVRFPGETAAPAKAGPLEAAPLGEAPLKEATLKEDWR
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: Y1096_GEOKA
Sequence: MFPKRQGIIVWLHSLKYGKQLRKFGNIHYISKRLKYAVLYCDMEQVDHVMKKLASLPFVKRVEPSYRPFLKLEFESKGEKEKDSPYPLG
What are the official names of this protein?
UPF0298 protein GK1096.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIG7_CAEEL
Sequence: MKLINCISIALLCTLVDFSSAEITVISNLAVVGSPESHVGTPNKTLYANIQNLWCGAQNLGEHIDVEYGEFTRLSDGKVFKGTVNQGKVYLEIGKASVKVAGRYRCEVRTLDKEIHSGNLIIYMPPVLDFPAAVRVSEVLNARPPHVIGAERRGLHGERMVLECPVLANPEPMVRWEKNGEPLGNSDSIEYDGNNLILNSLTEDHIGKYRCIGDNSFPLFVDGPAIPHQIYFDQDIKVL
What is the function of this protein?
Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
What are the official names of this protein?
Zwei Ig domain protein zig-7, 2 Ig domain protein zig-7.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMKL_SACD2
Sequence: MPTETNQNTTQYDLFVSCSQGWEGLLQTELEQLAVGDVKPGHAGVYVSATLEQMYKICLWTRLATKVLLPLDSGPIETGDDVHTVASKVDWPSLMKPGASLKVDFIGTNDAVRNTQFGAQRVKDAVVDSIRHAGGERPNVEKMQPDVRIHARLHRDELHISIDLSGDSLHRRGYRQKQGGAPLKENLAAALLLRAGWPTIAEQGGALLDPMCGSGTLLIEGALIAYSIAPGLSRDKFGFECWTGHNADTWAQVVNDAKAIRDKNLQEKSFDIFGYDSDYYVTKAAEMNCEALGLQNVIHIANKPVEELKQPTHKVLVPGLVIVNPPYGERLGEVNELRTTYQILAHQVKQQFEGWTFAVFTSNPELAKETRLRANKKNKFKNGALPAELFVYSVLSADDAKLRKDKLTQAVQTDEDGQVENASGAWVRKNLCDKPLTEAATMVANRIKKNLKRLKKSVKQNDWHGYRVYDADMPEYSAAIDLYNDQVHIQEYAAPKTIDADKAEARFETLKHGAAVALQAPDNKLFVKTRKRNKGKAQYEKQTDTQGFDAERCIQVQEGNAKLWVNLQDYLDTGLFLDHRPLRMRIHKEATGKRFLNLFCYTATASVQAALGGATESVSVDMSNTYLEWADNNFRLNNVHLARHRLVRADCFDWLNKCREGFDLIMLDPPTFSNSKKMSDVLDIQKDQVRLISRCMDILNPGGTLYFSTNFRQFKLDEQISTRYVVENISAATIDEDFKGNPKIHYCWKIQH
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR2_PINTH
Sequence: MSRRYWNIDLEEMMEARVHLGHKTRKWNPKMAPYIFTERKDTHIINLAKTARSLSEACDLLFDIAGRGKQFLIVGTKYQATDLVASAATEARCHYVNRKWLGGMLTNWSTTETRLQKFKDLKKEQDTGRFNQLPKKEAAMLKRQLDQLQKYLGGIRYMTSLPDIAIITNQREESIALGECRTLGIPTICLVDTDCDPDLVDIPIPANDDGIASIQLILNRLTSAICEGRALRSL
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YAII_ECO24
Sequence: MTIWVDADACPNVIKEILYRAAERMQMPLVLVANQSLRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEAIEKGAAALNPRGERYTPATIRERLTMRDFMDTLRASGIQTGGPDSLSQRDRQAFAAELEKWWLEVQRSRG
What are the official names of this protein?
UPF0178 protein YaiI.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ATDA_ECOLI
Sequence: MPSAHSVKLRPLEREDLRYVHQLDNNASVMRYWFEEPYEAFVELSDLYDKHIHDQSERRFVVECDGEKAGLVELVEINHVHRRAEFQIIISPEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFSVEGELMHEFFINGQYRNAIRMCIFQHQYLAEHKTPGQTLLKPTAQ
What is the function of this protein?
In addition, may act as a modulator of transcription through its ability to interact with the two-component response regulator RcsB.  Inhibits transcription of the small RNA regulator rprA in an acetylation-independent manner.  Interaction with the DNA-binding domain of RcsB might be responsible for SpeG-dependent inhibition of RcsB-dependent rprA transcription (PubMed:30562360).  SpeG does not acetylate RcsB in vitro (PubMed:30562360).
What are the official names of this protein?
Spermidine N(1)-acetyltransferase, SAT, Spermidine/spermine N(1)-acetyltransferase, SSAT.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF244_IIV6
Sequence: MDNCKILFIGDPHFKVNNIEIIDEFIHQCLEQLTSDIDICVIGGDILHTHERLHTTALNKAINFIDQVRKICPTYILVGNHDYENNQQFLSKRHWMNALKEWTNTFIIDYTSIIKIKNFTFGMVPYVPPGRFVEALNIIDNEWWKNVNCIFAHQEFYGCKMGAIESTEGDKWDHSFPLVISGHIHSEQRPQKNIFYPGSVIQHAFGESEDNGLLLLIFNDPEIGEYPLMVKKILDIPKMRTINVKISDFSTLVLDPKKNERIKIICKGSVESFKAFKKNKVV
What are the official names of this protein?
Putative phosphoesterase 244L.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. IIV-6 244L family.
Protein: ELP1_RABIT
Sequence: MRNLKLLQTLEFKDIQAPGKPQCFSLRTEPGTVLIGSEHGLIEVDPVTREVKNEIPLVAEGFLPEDKSGCIVGIQDLLDQESVCIATASGDVILCNLSTHQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIMEQQIHQDDFGESKFITVGWGKKETQFHGSEGRQAAFQIQTHESALPWDDHRPRVTWRGDGQFFAVSVVCPETGARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKPNQQDVVFFEKNGLLHGQFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQREEDSVLKTYVQLWTVGNYHWYLNECLPFSTYGKSKIVSLMWDPVIPYRLHVLCQGWHYLCYDWRWTTDRSSGDNESDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVNQVTFCALPKKSNDLAVLDASNQISVYKCGDSPSMDPTVKLGAVGGNGFKVSLRTPHLEKRYKIQFESNEDQETNPLKLSLLSWIEEDIFLAICHSQCSPQQSVIHRLTVVPCEVDEEQGQLSVSSSISVDGIIISMCCNSKTKSVALQLADGQILKYIWESPSLAVEPWKNPGGFPIQFPYPCIQTELAMIGGEECVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQCYCLKDASIKTLQAGLSSSHVSNGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVFLQNVETFIRQIDCVNHINLFFTELKEEDVTKTMYPPPVPSSVQQSRDPGGTKLDLICDALRVAMENINPHKYCLPILTSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGPEYFSECLNLIKDKNLYNEALKLYPPTSQEYKDISIAYGEHLMEEHQYEPAGLVFARCGAHEKALSAFLTCGSWQQTLCMAAQLNMTEEQLAGLGRTLAGKLAEQRKHSDAAIVLEQYTQDYEEAVLLLLEGAAWEEALRLVYKYNRLDIIETNIKPSILEAYKNYMAFLESQSATFSRHKERLLEVRELKERAQQVDLDDEMPHGQEADLFSETSSIVSGSEMSSKYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALNEVVQSLDKLKDEVYRILKVLFLFEFDEQGRELQKTFQDTLQLVERSLPEIWTLTYQQNSAMPVLGPSSTANSIMASYQQQKTSVPVLDAELFVPPKINRKTQWKLSLLE
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).  Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).  ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).  May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).
What are the official names of this protein?
Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ELP1/IKA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSBZ_SYNE7
Sequence: MVILFQLALLLLVVMSFVLIVGVPVLYATNGDRVQSNRLILVGGLAWTALVVLVGVLNYFVV
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: DNAG_METBU
Sequence: MQNTDTTKYIIHSKISADGIIERPDIVGAIFGQTEGLLGSDLDLRDLQKTGRIGRIEVAVGAKGGKTKGNIFIPSSLDRVETSILAASLETIDRVGPCAAKIEITQVEDVRATKRKHIIERAKFILTDMFDENLPESQEIADEVRQSVRIEEMQYYGKNKIPCGPNVVESDAIVVVEGRADVLNLLRYGIKNTICVGGTNVPPEVAELTKKKTVTAFTDGDRGGKLIIKELLQVADIDYIARAPDGKSVEDLVQREIVRSLRQKIPVEQALENYTIKTDAKPVTTETPAKGSRITRLPKRKERPELSVPAVKQLPNKPSRSEEKPGVTREPRTTREPRTTREARTTRETRSPRETRSPRETRSPRETREPKEAKPAMLSPQALRFKPHSDALIGTLGARLLDSKDEIIEETAVRDLVNTLKENDEGIKSVVFDGVVTQRILDIASDKGIENLIGVKKGNIAKSPASVNVLTASDF
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: SMC_MYCTO
Sequence: MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGEQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSITRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRRQLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVFQAEAAMRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSALAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQLLAELDAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGLARLAGQVETMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVGLDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRKDGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAADALAVDGLTAAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGAQWALDLVESPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDGDLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGALTEQSARQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQQRTEQEAVRTQTLDDVIQLETQLRKAQETQRVQVAQPIDRQAISAAADRARGVEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARAARLHAAAVAAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAAVRDEVNTLSARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPADLITEYGPHVALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKRAERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADVDARILQVFNDAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEVEARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLLSLFEQLREQSQIIIITHQKPTMEVADALYGVTMQNDGITAVISQRMRGQQVDQLVTNSS
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_ACICJ
Sequence: MNYREYQQIVRRKSRQISVGPVKVGGDAPITVQTMTNTPTDDVAATVAQIHRAERAGVDIVRVSCPDEAATAALADIVRQVNVPIVADIHFHYRRAIEAAKAGAACLRINPGNIGSAERVREVVAAARDHGCSIRIGVNAGSLEKHLLEKYGEPNPDALVESALEHAKILQDHDFHEFKISVKASDVFMAVAAYQQLAEVCDHPLHIGITEAGGRRTGTVKSSIGLGSLLWAGIGDTMRVSLSAEPEEEVAVGWDILKSLGIRHRGVRVISCPSCARQGFNVIDTVAQLEDRLAHIEEPITLSIIGCVVNGPGEALMTDLGVTGGGNGRHMVYAAGKTDHTIEGAAMIDHVVELVEQRAARLREEKAAAKQAAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YPT52_YEAST
Sequence: MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQSITIHPNDGNETKDVVIKFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSLQKARNWVDELKNKVGDDDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAISTEEAKQYAQEQGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKQNRQIGGGNNGQVDINLQRPSTNDPTSCCS
What is the function of this protein?
Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway.
What are the official names of this protein?
GTP-binding protein YPT52.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum. Note=Also found in association with endoplasmic reticulum vesicles having SED5 on their surface.