PharMolix/UniProtQA huggingface dataset:
Protein: YQEH_BACSU
Sequence: MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKNYNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVGNKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGKDVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPGIINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFICYMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVFSGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI
What is the function of this protein?
Binds GTP and GDP.
What are the official names of this protein?
Uncharacterized protein YqeH.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Protein: RS12_STRPN
Sequence: MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKRGVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ISPG_PERMH
Sequence: MIKRRKTREIDVGGVKIGGDNPVVVQSMTDTKTHNIEETLSQIKRLADAGCEIIRVAVPTEKDAEALKEIVKRSPIPVIADIHFSPRIAFTALESGIHGIRLNPGNINDEGKIREILQECKKKNITVRLGVNSGSLEMGILEKYGFPSGEALAESALNWSEFFEKVGFTKFKVSIKGSDVLQNIEANKIFAEKTDIPLHIGITEAGPAGRGSVKSAVGLGILLYMGIGDTVRVSLTADPEEEVKVAYQILQSLGLRRRGIEIVSCPTCGRIEVNLPEVVRKVEEKLDGKNIPIKVAIMGCVVNAIGEAREADIGLACGNKSAILFKKGEPVKRVSEDQMIDQLLKEIDNLEI
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: CO8G_RABIT
Sequence: MVLRGRAVLLAVLLAAGSLGRWAQKPRGAPSAISAIQPKANFDAQQFAGTWLLAAVGSACHFLQEQGHRAEATALHVAPQGAAMAVSTFRKLDGICWQVSQRYGATGVPGRFLLPARGPRGAVHVVAAETDYHSFAVLYLERARQLSVKLYVRSLPVSDSVLGAFEQRVAQANLTQDQVLFFPTYGFCEAADQFHILDEVRR
What is the function of this protein?
C8 is a constituent of the membrane attack complex.  C8 binds to the C5B-7 complex, forming the C5B-8 complex.  C5-B8 binds C9 and acts as a catalyst in the polymerization of C9.  The gamma subunit seems to be able to bind retinol (By similarity).
What are the official names of this protein?
Complement component C8 gamma chain.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACP_AZOC5
Sequence: MSDIAERVKKIVAEHLGVEPEKVTENASFIDDLGADSLDTVELVMAFEEAFNTEIPDDAAETILTVGDAIKFLEKNAG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDGC_SALTY
Sequence: MLWFKNLMVYRLSRDITLRAEEMEKQLASMTFTPCGSQDMAKMGWVPPMGSHSDALTHTANGQIIICARKEEKILPSPVIKQALEAKIQKLEADQGRKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLALENPIELTLTEWVRSGTVAQGFQLLDEAELKAMLEDGGVIRAKKQDLVSDEIAVHIEAGKVVTKLALDWQQRIQFVMCDDGSIKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQSLVEGLGGEAQR
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: FRE3_YEAST
Sequence: MYWVLLCGSILLCCLSGASASPAKTKMYGKLPLVLTDACMGVLGEVTWEYSSDDLYSSPACTYEPALQSMLYCIYESLNEKGYSNRTFEKTFAAIKEDCAYYTDNLQNMTNADFYNMLNNGTTYIIQYSEGSANLTYPIEMDAQVRENYYYSYHGFYANYDIGHTYGGIICAYFVGVMILASILHYLSYTPFKTALFKQRLVRYVRRYLTIPTIWGKHASSFSYLKIFTGFLPTRSEGVIILGYLVLHTVFLAYGYQYDPYNLIFDSRREQIARYVADRSGVLAFAHFPLIALFAGRNNFLEFISGVKYTSFIMFHKWLGRMMFLDAVIHGAAYTSYSVFYKDWAASKEETYWQFGVAALCIVGVMVFFSLAMFRKFFYEAFLFLHIVLGALFFYTCWEHVVELSGIEWIYAAIAIWTIDRLIRIVRVSYFGFPKASLQLVGDDIIRVTVKRPVRLWKAKPGQYVFVSFLHHLYFWQSHPFTVLDSIIKDGELTIILKEKKGVTKLVKKYVCCNGGKASMRLAIEGPYGSSSPVNNYDNVLLLTGGTGLPGPIAHAIKLGKTSAATGKQFIKLVIAVRGFNVLEAYKPELMCLEDLNVQLHIYNTMEVPALTPNDSLEISQQDEKADGKGVVMATTLEQSPNPVEFDGTVFHHGRPNVEKLLHEVGDLNGSLAVVCCGPPVFVDEVRDQTANLVLEKPAKAIEYFEEYQSW
What is the function of this protein?
Siderophore-iron reductase responsible for reducing extracellular iron prior to import.  Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores.  Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane.
What are the official names of this protein?
Ferric reductase transmembrane component 3, Ferric-chelate reductase 3.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YGIE_SCHPO
Sequence: MTENETLQKSSWKRHFTSTFPNRVKKIFKIKHSSSIPIVRVQPPTPRNSALFTTADFISYTTVYKV
What are the official names of this protein?
Uncharacterized protein C2A9.14.
Protein: AIM2_MOUSE
Sequence: MESEYREMLLLTGLDHITEEELKRFKYFALTEFQIARSTLDVADRTELADHLIQSAGAASAVTKAINIFQKLNYMHIANALEEKKKEAERKLMTNTKKRGTQKVENRSQAENCSAASATRSDNDFKEQAATEVCPQAKPQKKQMVAEQEAIREDLQKDPLVVTVLKAINPFECETQEGRQEIFHATVATETDFFFVKVLNAQFKDKFIPKRTIKISNYLWHSNFMEVTSSSVVVDVESNHEVPNNVVKRARETPRISKLKIQPCGTIVNGLFKVQKITEEKDRVLYGIHDKTGTMEVLVLGNPSKTKCEEGDKIRLTFFEVSKNGVKIQLKSGPCSFFKVIKAAKPKTDMKSVE
What is the function of this protein?
Also acts as a tumor suppressor independently of its role in inflammatory response (PubMed:26095253).  Able to suppress overt cell proliferation in enterocytes: restricts stem cell proliferation in the intestinal mucosa in an inflammasome-independent manner, contributing to a decrease in the likelihood of colorectal cancer development (PubMed:26095253, PubMed:26107252).  AIM2 suppresses cell proliferation by inhibiting phosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26095253, PubMed:26107252).  Inhibits AKT1 phosphorylation both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (PubMed:26107252, PubMed:33505023).  Also acts as a key regulator of regulatory T-cells (Treg) homeostasis by promoting their stability: acts by preventing AKT1 activation (PubMed:33505023).  Its role in Treg homeostasis is important to restain autoimmune diseases (PubMed:33505023).
What are the official names of this protein?
Interferon-inducible protein AIM2, Interferon-inducible protein 210, Ifi-210, Interferon-inducible protein p210.
What is the protein family that this protein belongs to?
Belongs to the HIN-200 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: YOBA_ECOL6
Sequence: MASTARSLRYALAILTTSLVTPSVWAHAHLTHQYPAANAQVTAAPQAITLNFSEGVETGFSGAKITGPKNENIKTLPAKRNEQDQKQLIVPLADSLKPGTYTVDWHVVSVDGHKTKGHYTFSVK
What are the official names of this protein?
Protein YobA.
What is the protein family that this protein belongs to?
Belongs to the CopC family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HSCB_BUCA5
Sequence: MNYFALFDLPRKFNIDKKLLSQNFYKLQLKFHPDLFINDSESKKKIILEKSIQINKGYKTLKNFLNRAIYFLCLNGYEVKKETLLLKNNDFLIRYFSLYEQLDNLKENNFNKKELNNLEQIIQKKIIYCKKKIELEFEKTRYKKVIKIISELLFFEKIKDVLKKEYNIYLRQIN
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: Y2806_SERP5
Sequence: MLAGMPSLSHLEQQEAADRIHLLMEQGMSSGEAIARVAQEIREKHQGDQVSVMFDDEDDDEEYQERPDDQADDDSEEDENY
What are the official names of this protein?
UPF0181 protein Spro_2806.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: ATPH_ACOAM
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: BCLF1_MOUSE
Sequence: MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPREESRGRSSFYPEGDQETAKTGKFLKRFTDEESRVFLLDRGNIRDKEAPKEKGSEKGRADGDWDDQEVLDYFSDKESAKQKFHDSEGDDTEETEDYRQFRKSVLADQGKSFATSSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETAYIVERPSTAKDKHKEEDKGSDRITVKKEVQSPEQVKSEKLKELFDYSPPLHKSLDAREKSIFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQANKSTSESFIQHIVSLVHHVKEQYFKSPAVTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERGFKEEIQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKPYKDDSKHKGRERDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKDYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDDEETMENNEEKKDRRKEEKE
What is the function of this protein?
Death-promoting transcriptional repressor.  May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity).
What are the official names of this protein?
Bcl-2-associated transcription factor 1, Btf.
What is the protein family that this protein belongs to?
Belongs to the BCLAF1/THRAP3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
Protein: RL23_OLEA2
Sequence: MDYTQILIKPLVSEKATFVKESSEQVVFFVNPRANKIEIKKAVESVFNVKVAGVNVVTRKPQARTKHGRVTGQTAGYKKAYVTLAPGEKIDFFEGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RL19_ONYPE
Sequence: MSQLKGQNLIESVNQHQLKDVPFFKPGDTVKVFIKIDEGNRKRVQIFEGLVIKRQGRLVTETFTVRKIFAGVGIELTFPVHSPTNEKIEVVRRGIVRRAKLHYVRNLSSKASRIKEQR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YBEY_CLAMS
Sequence: MSIEINNESAVEVDEPLIQRLATYALDTLHVHPDAELAIVMVDEGAMEQLHVQWMDEPGPTDVLSFPMDELRPGTEDRPTPAGLLGDIVVCPQVAAEQAVTAGHSTMEEILLLTAHGILHLLGFDHAEPDEEREMFGLQRDILIGFAMSERGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP35_HUMAN
Sequence: MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGAEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALACVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITEDTPPTSLYIEGLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEEEEKVEKETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYLQEQEKEARSRAAYISALPTSPHWGRGFDEDKDEDEGSPGGCNPAGGNGGDFHRLVF
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 35, Deubiquitinating enzyme 35, Ubiquitin thioesterase 35, Ubiquitin-specific-processing protease 35.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: WUHO_DROVI
Sequence: MTTIFYAEPELVLGHGRKVLFLNPNDLQIFKDIELPADLTTCGLKIAAGETNEEQQQPVGSEKAAAAGTNLEVSIVNVSYSPDRQLIALTTAGQKALLLYKSRPEHAKLLSVRALARASSSLAFAPDSSSVLVTDKTGDCYRYDCVELEAPPQLLLGHLSIVYDILWTPDQKYIITCDRDDKIRVTNYPATYDIHSYCLGHKEFVSGLALLTGTEHLVSASGDKTLRVWNYLSGKQLLQHELPAPAVRLQLRQLLPAKRFQVAVLFYDHVEALGLYELALDEQSNDAWTIARQQLVRAEAGSWNISCFALTADSIYVAGALDERLTLRVYNSSDGEQAKTVPTGWLDMVTERFADQTCVPEDLSVWFKKRYDNVSDYMERKKRRIEDHQQQQQQQKS
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.  Required during gametogenesis.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes.
Protein: UTP25_EMENI
Sequence: MPFRGGGQKGRGRGSVKRKGPGFTAARVDEVEYAEGLDDDVLSDSDESDQQSGQPYNELLQLLQAKTDSKGPARKKRKTSHQNKEGTEEAENVAEMTAVEEGEETLDAELQQQEPDEEGDLEDGDVDAQEDSDDEESGNEPFESHFSSPDESELSQKIKAASENKWKNAKKELPGGLKIWRAIPDCGQDDVPLLAAMKSMSSVKVKRKLKSAVTERIPSLSGNVQQVSPYIFDYQDVLYGARTTSESADMRDMLAVHATNHVLKTRDRVLKNNARVAKEQDGDLELRDQGFTRPKVLYLLPTRQACVRVVESITRFFQPEQQENKKRFIDAFSASDDPSWEDKPQDFRELFGGNDDDMFRIGLKFTRKTLKFFTQFYTSDLILASPLGLRTIMDQADVKKRDHDFLSSVEVVIVDHTDALLMQNWDHVSYILKHLNLQPKEAHGCDFSRVRTWYLDNNARYVRQLILLSSFITPEINSVFSTHMHNVFGKVKLNPIYNGAIAELPLPVPVKQTFTRFDCLSPTKDPDARFKHFTTTILSTLVRNITTSRNRASAGGTLIFIPSYLDFVRLRNYFATSQQTTNVSFGAISEYTEPREISRARSYFMTGRQSVLLYTERLHHFRRFRIRGVKRIIMYGMPDNPIFWGEIVGFLGLDPAGVVEAAEGGVRALFSKYDALKLERIVGTKRVGNMLREKGGDTFTFM
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DNAT_ECOHS
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELTSFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: RPOC_LACCB
Sequence: MIDVNKFESMQIGLASPDKIRSWSYGEVKKPETINYRTLKPERDGLFDERIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRSKVRRERMGHIELAAPVTHIWYFKGIPSRMGLVLDMSPRSLEEIIYFASYVVIDPGDTPMEKKQLLTEREYREKREEYGQTFNAKMGAEAIKELLQDVELDKEVAELKEDLKSAQGQKRTRAIRRLDILDAFKESGNDPAWMVMDTIPVIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVGPWLKFYQCGVPREMALELFKPFVMRELVKRDMASNIKNARRKIDRQDDDVWDVLEDVIKERPVLLNRAPTLHRLGIQAFEPVLVDGKSIRLHPLVCEAYNADFDGDQMAIHVPLSDEAMAEARMLMLAAHHILAPKDGKPIVTPSQDVVLGNYYLTMEQKGREGEGMIFKDTNEVLMALQNGYVHLHSRIGIATNSFTDKPFTDDQKQKIMVTSVGKAIFNEIMPKDFPYLNEPTQDNIVNGVPDKYFIDKGEDINDYLEDAPLIDPFKKGFLSDIIAQVFKVYKVQRTSDLLDDMKTLGYTQSTNSGLTVGIADITNLKEKPEIVEAAHKKVATVSKQFRRGLITDEERHDRVIQTWNDAKDDIQQKLVDSFDPNNPISMMSDSGARGNISNFTQLAGMRGLMAAPNGGMMEVPVISNFREGLSVMEMFMSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLVVSAIREGNEMIEPLYDRLVGRFTMKDVLDPKSGEVLVKRNTLMDEDTAQMIVDAGVESVTIRSVFTCNTKHGVCQKCYGRNMATGEQVEVGEAVGTVAAQSIGEPGTQLTMRNFHTGGVAGGEDITQGLPRVQEIFEARNPKGEAVITEVTGEITAIDENPAEHTREITVKGETDTRTYSVPYASSVAVAEGDHINRGERLTGGSIDPKQLIKVRDVMATENYLLSEVQKVYRMQGVDIGDKHVEVMVRQMLRKIRVMDPGDTNILPGTLLDIADFKEKNTQAIISGGIPATGRPVLLGITKASLETNSFLSAASFQETTRVLTDASIRGKNDPLIGLKENVIIGKIIPAGTGMATYRHEEPKSVGTVSDSVYSISDIEKQMKAKDGQQGDTDKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DLL4_HUMAN
Sequence: MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV
What is the function of this protein?
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954).  Activates NOTCH1 and NOTCH4.  Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313).  Essential for retinal progenitor proliferation.  Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity).  During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
What are the official names of this protein?
Delta-like protein 4, Drosophila Delta homolog 4, Delta4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS19_ACIB3
Sequence: MPRSLKKGPFVDAHLFAKVEAAVASNSRKPIKTWSRRSMILPDFVGLTISVHNGRNHVPVIVTEHMVGHKLGEFAPTRTYRGHGVDKKSKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: CLAH_PENCR
Sequence: MPNYEKVEFQTLDGLTLRGRLFRAEGAGGNRTAAVVITPPYVIVQDVMVSDIAVYFSQQGITALTYDTRSFGESDGQPRCELDLSKQVDDYSDAFTFLASLPSVDPSKIGFWGISFCATVALNAAALDRRSRFVISVGPIVKASDENPYPIDKVHRVLTKALRDRESQLRGNTPFYVESTCEDGSNPTGFGPELGIEAYELVQRIAASGIAPNFSTQLTLQSFAKILRWHPMQDIKWLGETPMMLMIPGDDTVSLPEEQMRLFDMITGPKRVEVAAGKSHFNVLASEGFEGLMDMQVEFIKQTLGLSS
What is the function of this protein?
Polyketide transferase; part of the cla gene cluster that produces clavatol and ortho-quinone methide (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).  The function of the polyketide transferase claH has not been investigated yet (Probable).
What are the official names of this protein?
Polyketide transferase claH, Clavatol biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the polyketide transferase af380 family.
Protein: RL21_DESVH
Sequence: MYAIIETGGKQFRVEEGSKIFVEKLASEAGSEIVIDKVLMLGGGDVKVGAPYVENAKVTAEVVEHGRGEKVVIFKKWRRNDSRKKQGHRQDFTALKIKAITA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.