PharMolix/UniProtQA huggingface dataset:
Protein: AZOR1_BACHK
Sequence: MSKVLFVKANDRPAEQAVSSKMYETFVNTYKEANPNTEITELDLFALDLPYYGNIAISGGYKRSQGMELTAEEEKAVATVDQYLNQFLEADKVVFAFPLWNFTVPAPLITYISYLSQAGKTFKYTANGPEGLAGGKKVVVLGARGSDYSSEQMAPMEMAVNYVTTVLGFWGITNPETVVIEGHNQYPDRSQQIVEEGLENVKKVAAKF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: APOC1_ENHLU
Sequence: MRLFLSLPVLVVVLAMVLEGPAPAQAAPEISSTFERIPDKLKEFGNTLEDKARAAIETIKQSDIPAKTRTWFSETYNKVKERLKTAFS
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3BP1_MOUSE
Sequence: MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMPPPQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQPARRQSRRLPASPVISNMPAQVDQGVATEDRGGPEAVGGHPPPPALPPQPRPRGLISETE
What is the function of this protein?
GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form (PubMed:7621827).  By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration.  Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions.  Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles.  Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment.  It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway.  Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity).
What are the official names of this protein?
SH3 domain-binding protein 1, 3BP-1.
What are the subcellular locations of this protein?
Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol. Note=Localizes at the leading edge of migrating cells. Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content.
Protein: GATA_STAAB
Sequence: MSIRYESVENLLTLIKDKKIKPSDVVKDVYDAIEETDPTIKSFLALDKENAIKKAQELDELQAKDQMDGKLFGIPMGIKDNIITNGLETTCASKMLEEFVPIYESTVMEKLHNENAVLIGKLNMDEFAMGGSTETSYFKKTVNPFDHKAVPGGSSGGSAAAVAAGLVPFSLGSDTGGSIRQPAAYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPLTRNVKDNAIVLEAISGADVNDSTSASVDDVDFTSEIGKDIKGLKVALPKEYLGEGVADDVKEAVQNAVETLKSLGAVVEEVSLPNTKFGIPSYYVIASSEASSNLSRFDGIRYGYHSKEAHSLEELYKMSRSEGFGKEVKRRIFLGTFALSSGYYDAYYKKSQKVRTLIKNDFDKVFENYDVVVGPTAPTTAFNLGEEIDDPLTMYANDLLTTPVNLAGLPGISVPCGQSNGRPIGLQFIGKPFDEKTLYRVAYQYETQYNLHDVYEKL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: TYSY_RHIWR
Sequence: MTEHPEQQYLDAMARAWYGGDERVDRTGVGTKSLFGVTMRFDLSDGTVPLITTKKIFWKSAIKELIWFLSGDTNIRPLVMQNVHIWTDWPLDKYRKATGEAIDRDAFERRIVDDPAFAAEWGDLGPVYGKQWVDWPRYTPAGDGLFRREEKGVNQIAELVGMLRANPSSRRLIFTGWNVPELPGMALPPCHMTYQYHVAGGRLSGILYQRSCDLGLGFPFNIFEAAVLIRMLAQQADLEPGELVWMGADTHVYSNHGHLVEEQLSRSPRPFPRLSLARKPADMFSYALDDFVIEGYDPHPHIKAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFAN3_RAT
Sequence: MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFADFQKKQPDDDSTPSTSNSQSDLFSEETTSDNNNTSVTTPTLSPSQQSLPTELNVTSPSEEECGPCTDTAHVSLITPTKRSCGADSQSESEASPVKRPRLVENPERPEESGRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGREEAIMKMVKLDRKVGRSCQRIGEGCS
What are the official names of this protein?
AN1-type zinc finger protein 3, Testis-expressed protein 27.
Protein: Y2698_BURCJ
Sequence: MDARLLEIIVCPICKGPLHYDRAAQELICNADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGR
What are the official names of this protein?
UPF0434 protein BceJ2315_26980.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: SCAM3_ARATH
Sequence: MANRYDPNPFAEEEEVNPFANARGVPPASNSRLSPLPPEPVGFDYGRTVDIPLDRAGTQDLKKKEKELQAKEAELKRREQDLKRKEDAAARAGIVIEVKNWPPFFPLIHHDIANEIPVHLQRLQYVTFATYLGLVLCLFWNIIAVTTAWIKGEGVTIWLLALIYFIAGVPGGYVLWYRPLYRAFRTDSALSFGWFFLFYMLHIAFCVFAAVAPPVVFKGKSLAGILPAIDVLSGQAIVGIFYFIGFAFFCLESVVSIWVIQQVYMYFRGSGKQDQMRREAARGALRAAV
What is the function of this protein?
Probably involved in membrane trafficking.
What are the official names of this protein?
Secretory carrier-associated membrane protein 3, AtSC3, Secretory carrier membrane protein 3.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Protein: YJ95_SCHPO
Sequence: MVKRSSHRQVVLDEDDEENYNNNLDDEKMEVLLIPQSNSTTFASSDATQMYKKSRISSNSENKKQIPDTKTLLETFQKIKKTLECPICTEALQRPFTTHCGHTYCYECLLNWLKESKSCPTCRQKLYTQPSPAYLVYEIMNVVAASNSGFPLVGINENPAKKQKEVLFDGMFKQEDSHYPRSILVDSEDGVLRCARCQWELENPYHCDHCGFQISDDQDSGREWFWDGENAESDSSLNGDNTRGGNISTNRAFNNMGHAPITAVPQDWLRFDEGEEFVGSDLESDFSGPGEYDVDDGFIDNRATSQLSPVESDDDFVAPVNGSNGNGITALDSTDSEEIDIMNGFDEERDSGGTNMVSRSETCYNDGQRYDELRRELADIQNESLDSLNSSSNNSPSHNNIHSRQHPFSSDEDEGNIVTNGTGLRSSQSSSQNRGFDLEPYSEVFTASYPRRQARRTRTIQLDSDEES
What are the official names of this protein?
Uncharacterized RING finger protein C548.05c.
Protein: CSK2A_NEUCR
Sequence: MARVYADVNQNMPRAYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGINVVNYQKCVIKVLKPVKKKKIKREIKILQNLAGGPNIVALLDVVRDSQSKTPSLIFEYVNNTEFRTLYPRFNDFDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGQSNSDQLVKIAKVLGTDELFDYLDKYEIELDAQYDDILGRFQRKPWHSFINAENQRFVSNEAIDFLDKLLRYDHNERLTAKEAMAHPYFAPVRDEATRARYLAGETIN
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).  Phosphorylates the frq clock protein thus regulating the circadian clock (PubMed:11959847).
What are the official names of this protein?
Casein kinase II subunit alpha, CK II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein: NIPS1_MOUSE
Sequence: MAPRLCIISAAARRLFTKPRPRAGDLAAAGAVRFYSKDSEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPECLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRKERSKMLLSRRNQLLLEFSFWNEPQPRAGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
What are the official names of this protein?
Protein NipSnap homolog 1, NipSnap1.
What is the protein family that this protein belongs to?
Belongs to the NipSnap family.
Protein: Y1356_MYCBO
Sequence: MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVKTYRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT
What are the official names of this protein?
Uncharacterized protein Mb1356.
Protein: MDTH_AERS4
Sequence: MVERARRLGRWFLALDSLLVILGFFVVMPMISLRFVDQQGWAAGIVGLALGLRQLTQQGLGVLGGSLADKFGARPLIVGGMLLRAAGFASLAYAQSGLELILSCIISGLGGCLFDPPRAALVIKFTRPRQRGRYISLLMMLESAGAVVGALLGSWLLNFDFEYVCLLGAGLFVCAALCNLLILPPYKLSQRPTPIRAGLGQVLADKAFCRLVLILSGYYALWVQVMLIFPILVKQMAGTTTAVGWMYTLETAISLTLLYPLARYGEKHFKLENRLMAGVLLMTTGIGLVAFATTLPAVFVLLACFYLGIVIAEPARETLMTKLAQPGARGSYMGFSRLGLALGGMTGYVGGGALHDYANAQGQPWLPWLVLGTVGVTTLLLLVNCFHREPSLARVNI
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNH2_LACPL
Sequence: MPERTIADFKRLLADQPTASLLAAAQADPRKGVQQAYQHYLRQAEKQAVLVTRFNQHMRLERDFWAHGGQYVAGIDEVGRGPLAGPVVTAAVVLDDHFDLLEVNDSKQLTAKKRAALMPRILEEAVAVGIGVADAQQIDQLNIYEATRVAMAQAVRNLSVRPTRLLVDAMQVPVPIEQTRLIKGDAKSASISAASIVAKVVRDHLMTMYDQVYPGYDFADNMGYGTAKHLAGLASLGATPIHRQSFSPVRNAKRV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_HELPS
Sequence: MNAHKERLESNLLELLQEALASLNDSELNSLSVTRVECSKGKHHAFVFVLSQDHKILSKLKKAEGLIRQFVLQASGWFKCPKLSFVLDNSLEKQLRLDAIFNEIAKGKDND
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3142_DECAR
Sequence: MAITDWPEGERPRERLLAHGPAALSDAELLAIYLRVGVRGKSAVDLARDLLHRFDGRLGTLAEASLEELASVSGIGMAKAAQLKASFELTRRALSQEMATRDSFTSPGKVRDWLRLKLASRGHEVFMALWLDAQNQLLKAEELFTGTLTQTSVYPREVVKAALAHNAAAVILAHNHPSGIAEPSRADEMLTRSLKEALAMVDVKVLDHFIVAGNTPPLSFAERGLL
What are the official names of this protein?
UPF0758 protein Daro_3142.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: RLMN_PHEZH
Sequence: MGVTLDLARAPAQPLAPSRPNLSGMTRAELAACLVELGVVRPEKAKMRASQLWRWMHHYGVTDFEKMTDVAKETRAALAEVCAISRPQVVERQVSKDGTRKWLIRMAPGIEVETVYIPDVGRAGALCVSSQVGCTLNCTFCHTGTQALVRNLTAAEIVAQVQVARDDLGEWPSPKEDRRLSNIVFMGMGEPLYNLDNVAAAIDIIADNEGIAISRRRITVSTSGVVPELAALGERTQAMLAISLHATNDELREKLVPLNRKYPIAELMAAIRAYPGLSNSKRVTFEYVMLKGVNDSPAEAKALVNLLKGVPAKINLIPFNPWPGSQYECSDWGTIERFAAVLNRAGYASPIRTPRGRDILAACGQLKSESEKLRASARRKLAAGG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_BART1
Sequence: MFKEFKEFALKGNMIDLAIGVIIGGAFGSLVNSIVNDIFMPIIGLITGGIDFSNMFIQLAGEKQATLSAAKAAGATISYGHFITLLINFLIIAWVLFFFVKAMNKMRRKEEGESPNKTSSEEQLLTEIRDLLAKKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRXB2_YEAST
Sequence: MIKHIVSPFRTNFVGISKSVLSRMIHHKVTIIGSGPAAHTAAIYLARAEMKPTLYEGMMANGIAAGGQLTTTTDIENFPGFPESLSGSELMERMRKQSAKFGTNIITETVSKVDLSSKPFRLWTEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQQGISACAVCDGAVPIFRNKPLAVIGGGDSACEEAEFLTKYASKVYILVRKDHFRASVIMQRRIEKNPNIIVLFNTVALEAKGDGKLLNMLRIKNTKSNVENDLEVNGLFYAIGHSPATDIVKGQVDEEETGYIKTVPGSSLTSVPGFFAAGDVQDSRYRQAVTSAGSGCIAALDAERYLSAQE
What is the function of this protein?
Acts on mitochondrial thioredoxin 3.  Implicated in the defense against oxidative stress.
What are the official names of this protein?
Thioredoxin reductase 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AFTA_MYCS2
Sequence: MAARVLGQMVLAVLMASAVAGVAIAAIARVEWPAYNTSNQLHALTTVGQFGCLAGLFAAGLLWRRGRRTLARLGALAFISAFSVVTLAMPLGATKLYLFGVSVDQQFRTEYLTRLTDTAGLHDMTYIGLPPFYPAGWFWLGGRIAAATGTPAWEMFKPWSIVSITIAVALALVLWAAMIRFEYALVATAASTAAMLAYASTEPYAAIITVLMPPVFVLAWAGLRARTRGGGWAAIVGVGIFLGVAALFYTLLLVYAAFTLTIMALCVAVARRHIDPLLRLAVIAVISGAIALLTWAPYLLAAMRGEPADSGTAQHYLPDAGAELHFPMFSLTLHGALCMLGTVWLVVRARTSTRAGALAVAVVAVYAWSLLSMLTTLAGTTLLSFRLQPTLTVLLTTAGAFGFIEATLAIAHRYRPETSRRVVAAATAVGAIGAVTFSQDIPDVLRPDINVAYTDTDGTGQRADRRPPGAERYYREIDAKILEVTGVPRNQTVVLTADYSFLSFYPYYGFQGLTSHYANPLAQFDKRAAAIEGWATLGSADDFVAALDELPWEPPTVFLMRHGANDTYTLRLASDVYPNQPNVRRYHVELDSAVFDDPRFEVSDHGPFVLAIRKPGGKPETDGH
What is the function of this protein?
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases.  It is not able to add an Araf residue to a terminal Galf.
What are the official names of this protein?
Galactan 5-O-arabinofuranosyltransferase, Arabinofuranosyltransferase AftA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 85 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COW_CONMR
Sequence: MGKLTILVLVAAVLLSTQVMVQGDRDQPADRNAVPRDDNPGRARRKRMKVLNESECPWHPWCG
What is the function of this protein?
Inhibits high (L-type) voltage-activated calcium channels (Cav) in a calcium-dependent manner.
What are the official names of this protein?
Glacontryphan-M.
What is the protein family that this protein belongs to?
Belongs to the O2 superfamily. Contryphan family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAC_HALMA
Sequence: MFGGGGGMNPRKMKQMMEQMGIDMEDIDAQEVIIRTPDEELVFDDAEVQLMEAQGQKTYQVVGEPESRELGSGEGSAAAEGDSDESDSSSGVDEDDVELVAMRAGVDEDTAREALEANDGDLADAVDELE
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: DNAK_XYLFA
Sequence: MGKIIGIDLGTTNSCLAIIEGGKGRVIENSEGDRTTPSIVAYTKDGEVLVGAAAKRQAVTNPKNTFYAVKRLIGRKFGDAEVQKDLDLVPYKITQHDNGDAWVATADAKKLAPQEISAKVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKKGGDRKIAVYDLGGGTFDVSIIEIAEVDGEKQFEVLATNGDTFLGGEDFDKRVIDYLVDEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSSQQTEVNLPYITADASGPKHLNIKLTRAKLEALVDDLVRKSIEPCRIALNDAGLRTSDVQEVILVGGQTRMPKVQQAVADFFGKEPRKDVNPDEAVALGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQVFSTAEDGQSAVTVHVLQGEREQARFNKSLAKFDLAGIEPAPRGQPQIEVSFDIDANGILHVSAKDKKTNKEQKVEVKAGSGLSDSEIQQMVADAEAHREEDKKFQELVQARNHADGLIHSTRSAIKEHGSKVGGEVIGRVEASLAELEAAVKGDDKNQIEAKSKTLEEVAQSLHMAATAEQQSGSTGAGAGSSAKVDDVVDAEFTEVKGDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: IES2_YEAST
Sequence: MDSEASDIEAELSDSVSAGGEEYIDDDDYTEDIDDQIVTAKSSRRTARRSVPKGVRTSKRIRDKELSVEVDEDYDEEEDVLSPSKKRHLHTRSMDKRQVAATASEKSDIGDSKGNDGEIEDGILEEEESLEKELNRGGGKEVEKSEESYYAQNDVGQKGEEEQDGESGGYEDNEPSISKESDELVSVVNGNGNEEDDEVEATKENTTDSTRSTTTRSKMLLDLLEDGGSKKKLTDEEIQLRRAENARKRKNLSEKRLEEEKQDTINKLLKKRAGKSRSHLPNDDEKNDGSSSFVKPRRPYNSEGMTRILRRYEEDLFCTF
What is the function of this protein?
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
What are the official names of this protein?
Ino eighty subunit 2.
What is the protein family that this protein belongs to?
Belongs to the IES2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRE_HALVD
Sequence: MANAALIEALRAADAVQFGEFELSHGGTSSYYVDKYLFETDPRCLKLIAEAFAERVADDDKLAGVALGAVPLVAATAVETNKPYVIARKKAKEYGTAKRIEGALDEGEEVVVLEDIATTGQSAVDAVEALREAGAVVDRVVVVVDRQEGAAELLADHDIALESLLTAEDLLADADG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SLIB_SHEEP
Sequence: YADAIFTNSYRKILGQLSARKLLQDIMNRQQGERNQEQGAKVRL
What is the function of this protein?
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
What are the official names of this protein?
Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL20_ONYPE
Sequence: MAKISFTPARHRRRKKVLKMAKGYFGSKSTLYKTAHEQVMRSLQYAYRDRKQRKRDFRKLWISRINAGAMLCGMQYSYLMHGLALAKVDVNRKVLADLAHLQPGPVESVKAVEVLQQETQPQPEEKTSLQPEKVLSTELSEEKSDDTLETKPQTTQVKAKKPSLDLSKMLLHELKKLAKEHKVPNFHKLKKAEIVTALKKALAKKII
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RS19_HALS3
Sequence: MSTEYRTGREGEFTYRGHDLDELQEMSLEDVAELLPARQRRTITRGLSEEHHKVLAEARESGTEETANNPIRTHLRDMPVLPEFVGLTFAVYTGQEFERVEVQPEMIGHYLGEFQLTRSSVEHGQAGIGATRSSKFVPLK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: VE4_HPV29
Sequence: MADNSAHKKYPLLDLYTPPTTPPARPPKPRWGLRRDRNGNDAGLKQSGLGHSSSSSSSTSSSSSNRPRPTPPPRKPVHERVDQWTVTGPGTVTLQVKTPTGTQVILTVHL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: TFDP2_MOUSE
Sequence: MTAKNVGLPSTNAKLRGFIDQNFSPSKGNISLVAFPVSSTNSPTKILPKTLGPINVNVGPQMIISTPQRIANSGSVLIGNPYTPAPAMVTQTHIAEAAGWVPSDRKRAREFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNNHLAADSAYDQENIRRRVYDALNVLMAMNIISSLPTGKKRNQVDCNSAQECQNLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAVNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIARSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDPTTGATVPQSSVNQGLCLDAEVALATGQLPASNSHQSSSAASHFSESRGETPCSFNDEDEEDEEEDPSSPE
What is the function of this protein?
Can stimulate E2F-dependent transcription.  Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.  The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase.  The E2F1:DP complex appears to mediate both cell proliferation and apoptosis.  Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
What are the official names of this protein?
Transcription factor Dp-2, Dp-3, E2F dimerization partner 2.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.