PharMolix/UniProtQA huggingface dataset:
Protein: SYFA_ECOLC
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLX56_MORAL
Sequence: MKFRTLLIIFSLVFLLEIVSASEPQCGRDAGGALCHGNLCCSHWGFCGTTAIYCDVDQGCQSQCWSSPPPPSPPPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPGGPERPDHRCGRALGNPPCNPGRCCSIHNWCGSTAAYCRGSSCQYQCWNSLLSALISNGNNAISKIISKSVFDEMFKHMKDCPSKGFYSYDAFIIATTSFPHFGTTGDITTRKRELAAFFAQTSLATTGQRFDSQDLYVWGYCHINETTNGNDNDYCTSAHWPCPSGKKYNSRGAVQLTHNYNYGLAGEALGLDLINNPDLVATDPVISFKTAIWFWMAQHDNKLSCHDILINANSGYVIGNIIKNSGYQNGLITNTISTMRGIGYYKRYCDMLGVSYGDNLDSWYDQTHFSEVARM
What is the function of this protein?
Chitin-binding protein which slows larval growth when consumed by the lepidopteran species S. ricini and M. brassica, but not when consumed by the mulberry specialist B. mori.  Lacks chitinase activity.
What are the official names of this protein?
Mulatexin, MLX56, Latex protein.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_LACE2
Sequence: MVDAGSFKNGITIQYENGIWQVIEFQHVKPGKGSPFVRAKLKNIISGGVIENSFRPTEKFDLAHIDRSEYQYLYADGDLYNFMNTETYDQIALSADQVGDSLKFVKENEMVKLCSHEGNVFAIEPPISVELEVTETEPGIKGNTATGATKPAIVETGAKIMVPLFVNQGDKIKIDTRTGEYTSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_RHILW
Sequence: MKIKDHAVDTARAVAFLSRIPMPQSLFKTYDGRLGRLVRAFPFAGIVIGFVPALALLLLLGLRADPLMAALIALSIQVVVTGALHEDGLADTADGIGGGKSREQSLEIMKDSRIGTYGAIALILSFAIRAAALAAIARHSLPLTSVLAIPAVAALSRGAIAWHWQRLPPAKADGVAASNGQPDEGAMQFALASAGLVVALLIWPAFGLRPLVASLLASGIAALAFTAFIRRKLAGHTGDTLGATQQICEIAALCALATAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_METRJ
Sequence: MGKVIGIDLGTTNSCVAVMEGTQPKVIENSEGARTTPSIVAFTDDGERLVGQPAKRQAVTNPERTFFAIKRLIGRTYDDPMTQKDKGLVPYKIARGDNGDAWVEADGKKYSPSQISAFTLQKMKETAESHLGQPVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKKSGTIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDNRIVEYLTAEFKKEQGIDLTKDKLALQRLKEAAEKAKIELSSATQTEINLPYITADNTGPKHLALKLSRAKFESLVDDLVQRTIEPCRKALKDAGVSASEIDEVVLVGGMIRMPKIQEVVKSFFGKEPHKGVNPDEVVAIGAAVQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQTFSTAEDNQNAVTIRVFQGEREMAADNKLLGQFDLVGIPPAPRGMPQIEVTFDIDANGIVNVTAKDKATNKEHQIRIQASGGLSDADIDRMVKDAEANAEADKKRRELVEVKNQGESLIHATEKSVTEYGDKVPAADKGAIETAMTALKTALEGDDVEAIKARTTDLMQASMKLGEAMYAANQAAGPDAGAEAAASEKKDDVIDADFQEVDEKDQKKRA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ARAG_ECOUT
Sequence: MQQSTPYLSFRGIGKTFPGVKALTDISFDCYAGQVHALMGENGAGKSTLLKILSGNYAPTTGSVVINGQEMSFSDTTAALNAGVAIIYQELHLVPEMTVAENIYLGQLPHKGGIVNRSLLNYEAGLQIKHLGMDIDPDTPLKYLSIGQWQMVEIAKALARNAKIIAFDEPTSSLSAREIDNLFRVIRELRKEGRVILYVSHRMEEIFALSDAITVFKDGRYVKTFTDMQQVDHDALVQAMVGRDIGDIYGWQPRSYGEERLRLDAVKAPGVRTPISLAVRSGEIVGLFGLVGAGRSELMKGMFGGTQITAGQVYIDQQPIDIRKPSHAIAAGMMLCPEDRKAEGIIPVHSVRDNINISARRKHVLGGCVINNGWEENNADHHIRSLNIKTPGAEQLIMNLSGGNQQKAILGRWLSEEMKVILLDEPTRGIDVGAKHEIYNVIYALAAQGVAVLFASSDLPEVLGVADRIVVMREGEIAGELLHEQADERQALSLAMPKVSQAVA
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NAPA_SHIFL
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNSRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEELLAKKPELRGKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: G6P_BPFD
Sequence: MPVLLGIPLLLRFLGFLLVTLFGYLLTFLKKGFGKIAIAISLFLALIIGLNSILVGYLSDISAQLPSDFVQGVQLILPSNALPCFYVILSVKAAIFIFDVKQKIVSYLDWDK
What is the function of this protein?
Plays essential roles both in the entry of the viral genome into the bacterial host and in budding process.  The formation of the G3P-G6P complex termed adsorption complex is essential for correct termination of filamentous phage assembly (By similarity).
What are the official names of this protein?
Head virion protein G6P, Coat protein D, G6P.
What is the protein family that this protein belongs to?
Belongs to the inovirus G6P protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Multi-pass membrane protein. Note=Prior to assembly, G6P is found associated with the bacterial host inner membrane. There are about five copies of G6P in the mature virion. They are located together with G3P at the head side of the filamentous virion (By similarity).
Protein: PHOSP_PIRYV
Sequence: MSSRGRAIQKALANYPDFNQTLSALNEMEEQTEKSFSTFTTLSASNGSSPEYFLGSMLKESDESESVDDDESVNDDLSPENAVEPYKGSEGEDSFGDKDETVFFEEDLPWSAMVQKTVNGKLVAELSAPQGLTPKQLSQWTDSVLALMDLSKNIRLSSAKIDYLASGLKITEHMSSCFSSTAPPLLKEFQPVTLSHRDTSPERGPSSRPSRPTVMPPARTLILENTPSTPTPESTSSASGSPLNLPEIKPPKDWASIAIREFSLNPLSGDGPQYKGTLARLFGSLESALQYANGGNPSTKDMLIAGLRRKGIFNKIRIKYFLDPIYD
What is the function of this protein?
Essential component of the RNA polymerase transcription and replication complex.  Binds the viral ribonucleocapsid and positions the L polymerase on the template.  May act as a chaperone for newly synthesized free N protein, so-called N(0).  Plays a role in virion assembly (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the vesiculovirus protein P family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: MUG70_SCHPO
Sequence: MTVGTLSVVSSTASDTASHVSDTRKRQYQRDEALRKKIISELGKKSGNFESPVRKIRRNGEPGTVDSAALDPALTVHMQSLVTETAQLMAAKRQNCVLVVDDDEQLAGIVTATDIATRCVGAGLNARQTLIADIMSTSPLCITSDTRFDDALLLMIEHKFRHLPVVSDGGPDGSAGDEGDVIGIINMRACLREPLNRIARQQEAAQKLVEALEGAQEEIENKSVSGNTNSSSVSGNHAAEFLEYVESLKKKASGLEIMSLIDSSEEPFLVGTRTTVAEATESMARSGVSAVLVMDNGAVSGVFTAHDVVLRVLAAGLDPYRSSVIRVMTPHPDCALASLRVSTALERMIEGKFSNLPVVDESDAIIGMLSLFHLATAIEQTPEEEEEVFDQAENDAGIEPSNGFEDQQQQLLGNSNEVVENYDVNPPLPLNPLPSNTQQSESTYEYSARQLPKPPVQAWQNENLSSNNKPQEYVGVENDYNFSNNPPTAMSEQSFHPSVSQKPMDTPENGSNSFAASPYLQPYNSASQLAPSYVGSLPQYHGNPSFVEQALQDLVQPTDSASQIFPLNPQSPSQFTIKYRSIAGRVHRLRLDGINSVSDLRTAVEEREKEQLVTLTYIDDEGDVVELVSDSDLREAILLARRRGLPRLEVRGVAAFTNHLESSHPPISTVDSSIGSASVVEKGVANSIVDIHQPTAKADKGNSKKPIYIGIVSSSIVILAVSMWYLRRKR
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 70 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
Protein: RS6_CLOK5
Sequence: MGKYETIFILHPSLDEEGYKANVEKFKGVIENGGGVIENVDIWGKRKLAYEIKKVNEGYYTLITFNADPTLPKELDRVFRITDTVVRHIIVKDEK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: Y1054_AQUAE
Sequence: MFIAVLLGAYSHLETYFLRVEKYTIETEKLPKGTEIKIMNASDMHLGPVMREDRVEMVKRVYEREKPDILVATGDTVDGNMKNLDYLAQMLAELNPPLGKFAVLGNHEYYVGLNQSLDFLRKAGFRVLRGEAVEINNFLVIAGVDDSDGKRLGYRVFTDELEVLKNVDTKKYVILLKHKPRIKREAIKYVDLVLSGHTHGGVLFFVGYTILRLIFETDRGIKELAPGKYIIVSKGVGTGGPPMRLLSPPDVVIVTIKGKGN
What are the official names of this protein?
Uncharacterized metallophosphoesterase aq_1054.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily.
Protein: LARP7_HUMAN
Sequence: METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
What is the function of this protein?
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898).  Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487).  The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487).  The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838).  LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698).  LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898).  Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898).  U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898).  Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898).  U6 snRNA processing is required for spermatogenesis (By similarity).
What are the official names of this protein?
La-related protein 7, La ribonucleoprotein domain family member 7, hLARP7, P-TEFb-interaction protein for 7SK stability, PIP7S.
What is the protein family that this protein belongs to?
Belongs to the LARP7 family.
Protein: LIP2_STAAM
Sequence: MLRGQEERKYSIRKYSIGVVSVLAATMFVVSSHEAQASEKTPTSNAAAQKETLNQPGEQGNAITSHQMQSGKQLDDMHKENGKSGTVTEGKDTLQSSKHQSTQNSKTIRTQNDNQVKQDSERQGSKQSHQNNATNNTERQNDQVQNTHHAERNGSQSTTSQSNDVDKSQPSIPAQKVLPNHDKAAPTSTTPPSNDKTAPKSTKAQDATTDKHPNQQDTHQPAHQIIDAKQDDTVRQSEQKPQVGDLSKHIDGQNSPEKPTDKNTDNKQLIKDALQAPKTRSTTNAAADAKKVRPLKANQVQPLNKYPVVFVHGFLGLVGDNAPALYPNYWGGNKFKVIEELRKQGYNVHQASVSAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYKGIMPNWEPGKKVHLVGHSMGGQTIRLMEEFLRNGNKEEIAYHKAHGGEISPLFTGGHNNMVASITTLATPHNGSQAADKFGNTEAVRKIMFALNRFMGNKYSNIDLGLTQWGFKQLPNESYIDYIKRVSKSKIWTSDDNAAYDLTLDGSAKLNNMTSMNPNITYTTYTGVSSHTGPLGYENPDLGTFFLMDTTSRIIGHDAREEWRKNDGVVPVISSLHPSNQPFINVTNDEPATRRGIWQVKPIIQGWDHVDFIGVDFLDFKRKGAELANFYTGIINDLLRVEATESKGTQLKAS
What are the official names of this protein?
Lipase 2, Glycerol ester hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_LACP7
Sequence: MGLIKKIFGTHSEREIKLIRPTADKIEALEPDMMKLSDDELRGKTIEFKNRLKNGETLDDILVEAYAVVREAAKRTLGNRAYYVQLLGGIILHQGRISEMRTGEGKTLTSTFPAYLNALEGEGVHIVTVNDYLAKRDAEWMGEVHRFLGLSVGCILNDMDNDERRKAYNCDITYATNNELGFDYLRDNMVIYKEQLVMRDLHFAIIDEVDSVLIDEARTPLIISGQSGKSTRLYEACDILARQLTKGTAKELSKMDIIMKEDDQETGDFVVNEKEKAVNLTAEGVEKVERFFKIENLADPENLEIQHNIILALRAHYLMAIDKDYVVKDDEVLIVDDFTGRIMPGRRYSDGLHQAIEAKEHVKVKRESKTLATITFQNFFNKYTKKCGMTGTALTEENEFREIYGMDVVEVPTNRPVARIDKDDAVYRTKREKLNAVINAIVEAHKAGQPVLVGTITIEASEEISELLKKKNIPHKVLNAKFHELEAEIIADAGQKGAVTIATNMAGRGTDIKLGEGVTELGGLKIIGTERHESRRIDNQLRGRSGRQGDPGESCFYICLEDDLMRLFGSERLNTIFKSLGLPEGEQIEHKMLSGAIEKAQKKIEDNNFGIRKNLLEYDKVNNEQREIIYAERRKVLNGDSMRDVIFKMITDNVETCVNTSISDDQLPEEWDLAELNQMLLPIIPMEPVELKDNELRHMKRNELIHMLKEKAVKLYEEKEAEFPEKEHLREVERVVLLRVIDRKWMDHIDDMDQLRQGIGLQAYGQRDPKTEYKFSGFEMFDTMINAITEDTVKALMHVRIEQKVEREEVAKVTGTNRDESVAKAPVKRATKKVQPNDPCPCGSGKKYKHCCGGVGRI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: HSLV_ECOSE
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKR4_MOUSE
Sequence: MALELNQSAEYYYEENEMNYTHDYSQYEVICIKEEVRQFAKVFLPAFFTVAFVTGLAGNSVVVAIYAYYKKQRTKTDVYILNLAVADLLLLITLPFWAVNAVHGWILGKMMCKVTSALYTVNFVSGMQFLACISIDRYWAITKAPSQSGAGRPCWIICCCVWMAAILLSIPQLVFYTVNQNARCTPIFPHHLGTSLKASIQMLEIGIGFVVPFLIMGVCYASTARALIKMPNIKKSRPLRVLLAVVVVFIVTQLPYNVVKFCQAIDAIYLLITSCDMSKRMDVAIQVTESIALFHSCLNPILYVFMGASFKNYIMKVAKKYGSWRRQRQNVEEIPFDSEGPTEPTSSFTI
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.  Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization.  Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization.  Negatively regulates CXCR3-induced chemotaxis.  Regulates T-cell development in the thymus and inhibits spontaneous autoimmunity.
What are the official names of this protein?
Atypical chemokine receptor 4, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: TRUC_SALTY
Sequence: MLEILYQDPWLVAVNKPAGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRRLAQQFEQHHIRKRYHAIVRGWLMDDAVLDYPLVEERDKIADKFAREDKAPQPAVTQYRGLATVEMAVPTGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSAAEHFACRRLMLHASRLELTHPFTGQPLIIQAGLDETWMQALTQFGWRGLLPDNERVEFTAASRQDETHLT
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase C, tRNA pseudouridine(65) synthase, tRNA pseudouridylate synthase C, tRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: WASC2_CRIGR
Sequence: MNRTSPDSERPPGSEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEEQALKAEAEKSEQEKTREQKEVDLIPKVREAVNYGLQVLDSAFEQLDIKAGNSDSEEEDANERVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEEEKEEEESDEDFASRSDNDQNQHTTRMSDEEEDDDGDLFADSEKEGDDIEDIEENTKSKRPTSFADELAARIKGDMSNQLKEEQIADGKPQKTMKEKKEKRTPPDDEEDILFPPPKLTDEDFSPFGSRGGLFSGQGLFDDEDESDLFRETSRDRPAQAPVSEESSSPKPGKKIPAGAVSVFLDTSAPSLKEFQKHEQPTPGKNPHLPTPAGLFDDNDDDDDNFFVPSCNKPPKTDKVKSTSIIFDDEEGDLFREKPAPLPVASVSQADENTTRADKTITLPSSKNPKLVSETKTQKGLFSDEEDSEDLFSSQNSSKSKSASLLSSQLPTSGSLFGDEDEEDNLFGSAPAKKQVSSQQPQSQEKPKPSEQPKKKASALLFSSDEEDQWNITDSHTKLATDRKSKGELWDSGTIQGQEVKAVKKTNLFEEDDDEADLFAIAKDSQKKTQRTSLLFEDDDDSGSSLFGFPPASVPPATMKKESISKVPSLFSDEEENEVPSRVKSVDVKVGNGKEADVAKVTEKEGLLTASDQEAAGPSDLFSSSPLDKGTKGRTKTVLSLFDEEEDKVEDQSNTHVSKNDAEKGLKTDGRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTRVSVPLDGSLFGDDEDYDLFSSAKTQPVVPEKKGALKKDRPVSLKNEEAPESTEGSKEKSLWKAETPQDSSGLTPFKSREPSSRIGKIQANLAINPAALLPTAALQIPGTKPALCELAFPSSEPGRSHGPESVPTLAGSEEAGVSFDLPAQADTLHSANKSRVKVRGKRRPQTRAARRLAAQESSESEDMSVSRGPVAQLASSPILPNGHQPHLQPRMASGEISSEKAMAPAAPPWESGPALSAVDRSFFVASLPQTGNEADLFDSGDIFPKSIGSQSMEGTKVKAAETPAHLSGGSKEKSLVFPALSEASSTDDLFQTVKPRPAKKRNPFPLLEDEDDLFADRKGKKNELKSDSHQDIISKTQDIFEDDIFATEAVKPFQKKREKERTLEPNLFDDNIDIFADLNVKPKEKSKKKVEAKSVFDDDTDDIFSSGLQAKKSKPKSQSAEATSELRSDHKVSNIFDDPLNAFGSQ
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.  Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.  Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission.  Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2).  Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.  Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35.  Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 and C16orf62 homolog (By similarity).
What are the official names of this protein?
WASH complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the FAM21 family.
What are the subcellular locations of this protein?
Early endosome membrane. Cell membrane.
Protein: DAPA_BORPE
Sequence: MQFQGSLVALVTPMQPDGSLDYDAYRSLIDWHVAEGTDGLVVVGTTGESPSVSMEEHAELIRVAVEHAAGRIPVIAGVGANSTDEAIHLARHAKAVGAQAGLSVVPYYNKPNQEGIYRHFRAVAEAVDLPTVLYNVPGRTVADMSNDTVLRLAEVPGIIGIKEATGDIARGALLLREAPAGFQVFSGDDPTAAALILLGARGNISVTANVAPRLMHELCTAARGGDVPRTRELNARLARLNKALFIEANPIPVKWALAQMGHTALGYRLPMVELSEQYHSLVRTALQEVGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPLX1_NARJA
Sequence: MDFVMKQALGGATKDMGKMLGGDEEKDPDAEKKEEERLEALRQAEEERAGKYAKMEAEREVMRQGIRDKYGIKKKEEKEAEAMAAMEAQAEGSLTRPKKAIPAGCGDEDEEEESILDTVLKYLPGPLQDMFKK
What is the function of this protein?
Positively regulates a late step in synaptic vesicle exocytosis.
What are the official names of this protein?
Complexin-1, NJ-synaphin-2.
What is the protein family that this protein belongs to?
Belongs to the complexin/synaphin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: Y646_VIBPA
Sequence: MSIESDMIHVEVVYALPHEQRVFNLVVNNHATVEEIIRQSGVLELYPEIDLAKNKVGVFSRNVKLDATVRDKDRIEIYRPLLADPKEIRRKRAEQAKAAGNADPVTGGKPNALRK
What are the official names of this protein?
UPF0125 protein VP0646.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: CDH_ECO45
Sequence: MKKAGLLFLVMIVIAVVATGIGYWKLTGEESDTLRKIVLEQCLPNQQENQNPSPCAEVKPNAGYVVLKDRHGPLQYLLMPTYRINGTESPLLTDPSTPNFFWLAWQARDFMSQKYGQPVPDRAVSLAINSRTGRTQNHFHIHISCIRPDVREQLDNNLANISSRWLPLPGGLRGHEYLARRVTESELVQRSPFMMLAEEVPEAREHMGSYGLAMVRQSDNSFVLLATQRNLLTLNRASAEEIQDHQCEILR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.