PharMolix/UniProtQA huggingface dataset:
Protein: HPPA_CALS4
Sequence: MGAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIASLALIVAVIIVVANYYGHLSEGSSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIRAAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFLAYGGLSGQDELIKEAPSLIVGFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDESKDPMIALNKGYFVTTVVNLIALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIFVFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMESTALPVIFISAAIYIAYKLGEMAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDRLDACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGAFIGAMIVYLFSSTAIRAVGKAAQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGALKEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVILALYLNNGGGAWDNAKKFIELGNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR
What is the function of this protein?
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane.  Generates a proton motive force.
What are the official names of this protein?
K(+)-insensitive pyrophosphate-energized proton pump, Membrane-bound proton-translocating pyrophosphatase, Pyrophosphate-energized inorganic pyrophosphatase, H(+)-PPase.
What is the protein family that this protein belongs to?
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NANH_VIBC3
Sequence: MRFKNVKKTALMLAMFGMATSSNAALFDYNATGDTEFDSPAKQGWMQDNTNNGSGVLTNADGMPAWLVQGIGGRAQWTYSLSTNQHAQASSFGWRMTTEMKVLSGGMITNYYANGTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAATEYHKFELVFLPGSNPSASFYFDGKLIRDNIQPTASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGDVIFRGPDRIPSIVASSVTPGVVTAFAEKRVGGGDPGALSNTNDIITRTSRDGGITWDTELNLTEQINVSDEFDFSDPRPIYDPSSNTVLVSYARWPTDAAQNGDRIKPWMPNGIFYSVYDVASGNWQAPIDVTDQVKERSFQIAGWGGSELYRRNTSLNSQQDWQSNAKIRIVDGAANQIQVADGSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYSALNHTTTLFVDGQQITTWAGEVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTPEVEKDLEKLGWTKIKTGNTMSLYGNASVNPGPGHGITLTRQQNISGSQNGRLIYPAIVLDRFFLNVMSIYSDDGGSNWQTGSTLPIPFRWKSSSILETLEPSEADMVELQNGDLLLTARLDFNQIVNGVNYSPRQQFLSKDGGITWSLLEANNANVFSNISTGTVDASITRFEQSDGSHFLLFTNPQGNPAGTNGRQNLGLWFSFDEGVTWKGPIQLVNGASAYSDIYQLDSENAIVIVETDNSNMRILRMPITLLKQKLTLSQN
What is the function of this protein?
Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources.  Sialidases have been suggested to be pathogenic factors in microbial infections.  Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides.
What are the official names of this protein?
Sialidase, Neuraminidase, NANase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS4_CHLL3
Sequence: MLIIPAIDIKDGKCVRLTRGDFSQQKIYLDNPLDMAIIWRKQNAKMLHIVDLDAALTGEMVNFERIRQIVEELDIPVQVGGGIRSADDVKRYLDMGVGRVVIGSAAVTNPELVRELMKTWRASKIVVGIDAVNGVPKIKGWTESANLKDFELAQRMKDMGIERIIYTDITRDGMLQGVGYETTRRFAELAGMKVTASGGVTNSEDLRRLAGLQYCGVDSVIIGKAFYECNFPCQELWYNFEEGICLDHNFSTARKR
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEO2_LACLL
Sequence: MKIGLVKANFPGERRVPLLPKDIKDFKNEILVEEGFGKFLDIDDQEYSDKGCHILSRAEVFAESEAIFSLKLIQPTDYYHLREGQMIIGWTHPFGSGQSFMKEQALPKKLIVVDLDSNSPCIYYENEIFESGIPKGLLYKNSFYAGYAGVLDALLQYGLIPTEETKIAILGSGNVAQGAFSSISKYSSNIRMYYRKTMSIFKENYTKYDIIINGIEIGKDDDPILSFSEQKSLKKGTLIIDVAADAGNTIEGSHFTSIDAPIYENAGKYYYVVPNTPSLIYRNVSQELSKILSENIFRKDCSRFIEKVKPLNK
What is the function of this protein?
Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine.  To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine).  NADH cannot replace NADPH in the condensation reaction.
What are the official names of this protein?
N(5)-(carboxyethyl)ornithine synthase, CEOS, N(5)-(L-1-carboxyethyl)-L-ornithine:NADP(+) oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family. CEOS subfamily.
Protein: KNOB_PLAFN
Sequence: MKSFKNKNTLRRKKAFPVFTKILLVSFLVWVLKCSNNCNNGNGSGDSFDFRNKRTLAQKQHEHHHHHHHHHHHQHQAPHQAPHQAHHHHHHGEVNHQAPQVHQQVHGQDQAHHHHHHHHHHLHPQQPQGTVANPPSNEPVVKTQVFREARPGGGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTVNDYSQENGPNIFALRKRFPLGMNDEDEEGKEALAIKDKLPGGLDEYQNQLYGICNETCTTCGPAAIDYVPADAPNGYAYGGSAHDGSHGNLRGHDNKGSEGYGYEAPYNPGFNGAPGSNGMQNYVHPWSGYSAPYGVPHGAAHGSRYSSFSSVNKYGKHGDEKHHSSKKHEGNDGEGEKKKKSKKHKDHDGEKKKSKKHKDNEDAESVKSKKHKSHDCEKKKSKKHKDNEDAESVKSKKVLKKREKSIMEKNHAAKKLTKKIKIKKKTNNSKSDGSKAHEKKENETKNTAGENKKVDSTSADNKSTNAATPGAKDKTQGGKTDKTGASTNAATNKGQCAAEGATKGATKEASTSKEATKEASTSKEATKEASTSKEATKEASTSKGATKEASTTEGATKGASTTAGSTTGATTGANAVQSKDETADKNAANNGEQVMSRGQAQLQEAGKKKKKRGCCG
What is the function of this protein?
KAHRP might mimick human histidine-rich glycoproteins to anchor host thrombospondin or a parasite analog in a binding complex with the endothelial cell receptor.
What are the official names of this protein?
Knob-associated histidine-rich protein, KAHRP.
What are the subcellular locations of this protein?
Secreted. Note=Cytoplasmic side of the membrane of infected erythrocytes.
Protein: EX7L_ECOUT
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQLKYEQLKAKLQAEGLFDLQYKKSLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTHQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALESQLKRAGQQQQRLTRQLVQQNPQSRIHRAQTRIQQLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTSAADGAVLKQVKQVKVGETLTTRLGDGVVISEVSAVTKTRKSRKKTSNP
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71BJ_ARATH
Sequence: MAISFLCVFLITFVSLIFFAKKIKRSKWNLPPSPPKFPVIGNLHQIGELPHRSLQHLAERYGPVMLLHFGFVPITVVSSREAAEEVLRTHDLDCCSRPKLVGTRLLSRDFKDIGFTPYGNEWKARRKFALRELFCLKKVQSFRHIREEECNFLVKQLSESAVDRSPVDLSKSLFWLTASILFRVALGQNFHESDFIDKEKIEELVFEAETALASFTCSDFFPVAGLGWLVDWFSGQHKRLNDVFYKLDALFQHVIDDHLNPGRSKEHEDIIDSMLDVIHKQGEDSSLELTIDHIKGFLANIFLAGIDTGAITMIWAVTELVKNPKLIKKVQGDIREQLGSNKERITEEDIEKVPYLKMVIKETFRLHPAAPLILPRETMAHIKVQGYDIPPKRRILVNVSAIGRDPKLWTNPKEFDPERFMDSFVDYRGQHYELLPFGSGRRICPGMPMGIAAVELGLLNLLYFFDWKLPDGMTHKDIDTEEAGTLTIVKKVPLKLVPVRVQ
What are the official names of this protein?
Cytochrome P450 71B19.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SH_MUMPR
Sequence: MPAIQPPLYLTFLLLILLYRIITLYVWIILTITYKTSVRHAALHQRSFFRWSFDHSL
What is the function of this protein?
Plays a role in the inhibition of the host NF-kappa-B pathway.  This inhibition occurs at the receptor level, by preventing the signaling of TNFR1 as well as IL-1R and TLR3.
What are the official names of this protein?
Small hydrophobic protein.
What is the protein family that this protein belongs to?
Belongs to the rubulavirus small hydrophobic protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: AROA_CHLMU
Sequence: MVPLNQAFLISPSAPYGEFSIPPSKSHSLRAILFASLSKGTSIINNSLSSPDTDTMLSACKKFGARITRVGETLHIQGNPPPYSQYSSHHFHMGNSGIALRFLTALSSLSPSPILITGAHTLKRRPIEPLLSSLEQLGSEIRQKKSSSIPFVIRGPISSGHVTISGQDSQYASALAITAAVAPHPLSFSIENLKERPWFDLTLDWLHSLNISFSREQDSLFFPGAQSIKSFSYSVPGDYSSAAFLAALGLLSSSSNPTVLYNLPSKDPQGDKQLFSLLKSLGADIVIEKDHIEIRPSSFSGGVIDMDPFIDALPILAVLCCFAKNPSHLYNALGARDKESNRIEAIAHELRKMGGSVHPTQDGLYIEPSRLHGAVVHSHNDHRIAMALAVAGVHASSGQTLLCNTQCVNKSFPHFVIAAQTLHANIRHHQADFSLRSSLCR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSHA_STAAW
Sequence: MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKESESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_ECOL6
Sequence: MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF12_PHATC
Sequence: MINWQVLGQLIATGTIMLAGPAVIVLLALKKGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PETG_ANEMR
Sequence: MVEALLSGIVPGLIPITLAGSFVIAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: ITR4_CYCPE
Sequence: RICPRILMECKADSDCLAQCICQENGFCG
What is the function of this protein?
Strongly inhibits trypsin, weakly inhibits chymotrypsin.
What are the official names of this protein?
Trypsin inhibitor 4, CyPTI-IV, Trypsin inhibitor IV.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMS_LACLA
Sequence: MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLGIDVSGTAGIGHTRWATHGKPTEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFKGQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAFALMDSEDAEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAELDLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLESLTNTPVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVASTKAYTGQIATLAFLAKAVGEAEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIVVNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RVE6_ARATH
Sequence: MVSRNSDGYFLDPTGMTVPGLGPSFTAAVSSSSSPTTSSTAVAVADVTAMVSSSEEDLSKKIRKPYTITKSRESWTEPEHDKFLEALQLFDRDWKKIEAFIGSKTVIQIRSHAQKYFLKVQKSGTGEHLPPPRPKRKAAHPYPQKAHKNVQLQVPGSFKSTSEPNDPSFMFRPESSSMLMTSPTTAAAAPWTNNAQTISFTPLPKAGAGANNNCSSSSENTPRPRSNRDARDHGNVGHSLRVLPDFAQVYGFIGSVFDPYASNHLQKLKKMDPIDVETVLLLMRNLSINLSSPDFEDHRRLLSSYDIGSETATDHGGVNKTLNKDPPEIST
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Protein REVEILLE 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: 5HT6R_RAT
Sequence: MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.  It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751).  Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).  Is an activator of TOR signaling (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 6, 5-HT-6, 5-HT6, ST-B17, Serotonin receptor 6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STHA_PSEFL
Sequence: MAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVRQIMQFNTNPMFRAIGEPRWFSFPDVLKSAEKVISKQVASRTGYYARNRVDLFFGTGSFADEQTVEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHPRIYDSDTILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFSNNNITVRHNEEYDRVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGMENIGVKVNSRGQIEVDENYRTCVTNIYGAGDVIGWPSLASAAHDQGRSAAGSIVDNGSWRYVNDVPTGIYTIPEISSIGKNEHELTKAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHRETLEVLGVHCFGYQASEIVHIGQAIMNQPGEQNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCBP1_DROER
Sequence: MSRRRAHDTEDESYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPAIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSFPFKHKIPLEYCIVEVIFAELFHMPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDGEHPRPKFIQEVLQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNYKYANEEAANLPGTAVAHQLVVAIRQKCTPEEVVTILKDIPSSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEAQICILHNIYELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKMYLWEILHLTIKKMNKHVIKLNSELSEAKDKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVALRA
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNC_SHEPA
Sequence: MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPAATEGDLSRMRATLVCGKMLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLLQEYLQKYRKPLPVYRVAHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_BUCAK
Sequence: MDKKSARIRRATRARRKLKELGATRLVVHRSPRHMYAQVIAPNGSEVLVAASTLEKAITEQLKYSGNKDAAAAVGKALAERALEKGIAKVSFARSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RAD23_YEAST
Sequence: MVSLTFKNFKKEKVPLDLEPSNTILETKTKLAQSISCEESQIKLIYSGKVLQDSKTVSECGLKDGDQVVFMVSQKKSTKTKVTEPPIAPESATTPGRENSTEASPSTDASAAPAATAPEGSQPQEEQTATTERTESASTPGFVVGTERNETIERIMEMGYQREEVERALRAAFNNPDRAVEYLLMGIPENLRQPEPQQQTAAAAEQPSTAATTAEQPAEDDLFAQAAQGGNASSGALGTTGGATDAAQGGPPGSIGLTVEDLLSLRQVVSGNPEALAPLLENISARYPQLREHIMANPEVFVSMLLEAVGDNMQDVMEGADDMVEGEDIEVTGEAAAAGLGQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFACDKNEEAAANILFSDHAD
What is the function of this protein?
Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair.  Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.  Involved in DNA excision repair.  May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
What are the official names of this protein?
UV excision repair protein RAD23.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SLBP1_XENLA
Sequence: MSDHWRTISEEHRPHAPSRWSQGRKRCSDGKLRRHDDTDSTVFDTKPSEEPQARPDSFTTPESHKPVARCKDWGSAVEEDEQLREKVDQDIARYRRKLLINEFGRRERRSSSGSSDSKDSSTHGEMETDPAVITRRQKQINYGKNTIAYDRYIKAVPRHLREPNVHPRTPNKFKKYSRRSWDQQIRLWRIALHQWDPPAAEGSDLQPFMEEDMVCTETSSQENLFTGTPTKVRKVEADDAFDLEPCFIEEELLS
What is the function of this protein?
Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP) (PubMed:8957003, PubMed:9858606).  Could play an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery.  Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity).
What are the official names of this protein?
Histone RNA hairpin-binding protein, Histone stem-loop-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLBP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear (coiled bodies).
Protein: FRSA_SALHS
Sequence: MTQANLSETLFKPRFKHTETSTLVRRFNRGSQPPMQSALDGKNVPHWYRMINRLMWIWRGVDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAKQAMDWQQKACQEQDAMRSGRYWLHASTLYNIAAYPHLKGDELAEQAQALANRAYEEAAQRLPGSLREMEFAVPGGSPVTAFLHMPKGDGPFPTVLMCGGLDAMQTDYYTLYERYFAPRGIAMLTLDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLEAPRLKAVACLGPVVHALLSDPQRQSTVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGFWKNDPFSPEEESRLITTSSSDGKLIEIPFNPVYRNFDRALQEITDWINHRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: CYSJ_BUCAP
Sequence: MKNKNPFNIFFPLSLDKIENLEKIKKNCSSIQYAWLSGYFWNLANQTPSRLICEKNEFFRKDNEEKIITIISASQTGNARQLAKRFNKYLKNENKKTNLIDAADYNFKKIKNERFLILIISTQGEGEPPEEALSFYKFIMSKKAPRLENLHYSVFGLGDVSYNLFCQAGKDFDKRFSELGGKSLLHRLDSDIEYESNYIQWSEELLLAINKIDVSTCSVFKKNDKKNFIDKLNYTKYKPAVATVLLNQKITGRNSTKDVHHIELDITNSNIVYTPGDALGVWYQNSSQLIKQILKLLSIRISDKVKVKDKIITIFEALKKNFELTTNTKHIIQKYTDVTQNKFLKKIISDNKKLNNYVKKTPLLKMIYDHPKKLSSQQLISILRPLKPRLYSISSSQSEMNDEVHITVGVVKKQISGTIHLGGSSSYLSQFLKIDDSVKIFVEEKSNFRLPENKDVPIIMIGSGTGIAPFRAFIQQRDNDKATGKNWIFFGNPNFTEDFLYQLEWQKYLKKKLLTKMSLAWSRDQKEKIYVQDKIRENGKELWEWVNQGAQIYVCGNASKMAKDVEKELLDVFSKNGSMDIEESSEFLNNLRITRRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.