PharMolix/UniProtQA huggingface dataset:
Protein: MTNA_UNCRE
Sequence: MASALEAIKYDRGRLFIIDQLQLPHVTKFIPIDSSEAGWHAIKAMQVRGAPAIAIVAVLSLAVEMLNLVSENMIPEDGEDVRAYIEQKMDYLVSSRPTAVNLSDSAQKIKLLLDQRARKSGLSGVETAMAFIQHAEQMLARDLADNHSIGEYGATWILKNTRAALEGGNTCVLTHCNTGSLATAGYGTALGIIRRLHEHGRLSRAYCTETRPYNQGARLTAYELVSDKIPATLITDSMAGQLLANPDKKIAAIVVGADRVAANGDTANKIGTYTLAVLAKFHNIKFVVAAPRTTIDMKTKTGNEIIIEERQSSEVTKIRGPCEGDGDHREAVMETIKIAADGIDVWNPAFDVTPAALIDAIVTEVGVETKDSSGQFHLSSLFESMA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HTPG_BACF6
Sequence: MQKGNIGVTTENIFPIIKKFLYSDHEIFLRELVSNAVDATQKLNTLASISEFKGELGDLTVHVSLGKDTITISDRGIGLTAEEIDKYINQIAFSGANDFLEKYKNDANAIIGHFGLGFYSAFMVSKKVEIITKSYKEGAQAVKWTCDGSPEFTLEEVEKADRGTDIVLYIDDDCKEFLEESRISALLKKYCSFLPVPIAFGKKKEWKDGKQVETAEDNVINDTIPLWTKKPSELSDEDYKKFYRELYPMSDEPLFWIHLNVDYPFHLTGILYFPKVKSNIDLNKNKIQLYCNQVYVTDSVEGIVPDFLTLLHGVLDSPDIPLNVSRSYLQSDSNVKKISTYISKKVSDRLQSIFKNDRAQFEEKWNDLKIFINYGMLTQEDFYDKAQKFALFTDTDGKHYTFEEYQTLIKDNQTDKDKNLIYLYANNKDEQFAYIEAAKNKGYNVLLMDGQLDVAMVSMLEQKLEKSRFTRVDSDVVDNLIVKEDKKSDVLEASKQEALSAAFKSQLPKMEKVEFNVMIQALGENGSPVMITQSEYMRRMKEMANIQAGMSFYGEMPDMFNLVLNSDHKLVKEVLADEEKECSAAIAPIQTELEDVTKRRDALKKKQEGKKDEDIPTAEKDELNDLDKKWDELKQQKDSIFAGYAGKNKVVRQLIDLALLQNNMLKGEALNNFVKRSIELI
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein htpG, Heat shock protein htpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COABC_ALIF1
Sequence: MASLAGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTKAAKEFITPLTMQAVSGHPVADSLLDPAAEASMGHIELAKWADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPVAVSPAMNQQMYSNIATQENIATLARRGMHIWGPAAGQQACGDVGMGRMLEPMELVHLCEDFFQANSCEQAEADEKPLKGQSLLITAGPTREAIDPVRYISNHSSGKMGFAIAEAAAQLGANVTLVSGPVNLATPENVKRIDIESAEQMHGAVMKNAQSHSIFIACAAVADFKLSQVATQKLKKTADEDGMTLHMVKNPDIVASVAALTNQRPFTVGFAAETQDVEKYARGKLERKNLDMICANDVSVQGQGFNSDNNALHLYWKEGDKALPLTTKSELGKAIMLEIVEKL
What is the function of this protein?
Catalyzes two sequential steps in the biosynthesis of coenzyme A.  In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.  In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
What are the official names of this protein?
Coenzyme A biosynthesis bifunctional protein CoaBC, DNA/pantothenate metabolism flavoprotein, Phosphopantothenoylcysteine synthetase/decarboxylase, PPCS-PPCDC.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PPC synthetase family.
Protein: RL20_META1
Sequence: MRTRGGIVTKRRRNKWLKLAKGYWGHKSIGFKVAKQAVVKSWTYAFRDRKQLKREFRKLWIARINAAARPLGITYSRLIEGLKVANIQINRKMLSELAINYPTAFSQIVEKAKTSLAKK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MACH_PENTR
Sequence: MALLSVLPVSLWLIAAGTFAVYHAIRAVYLIFFSPLAVFPGSPWAALGEYWEAYWNIGVKPGRKGQMLFKLEEMHKRLGPALRMGPNEVHIYDPAFYHELYRPGSRYYKDPSMHKVLGAPSSTLAESDPVRHKQRKAPLEPLFSKKNILSLEPMLMEHVDRCSQRFDELFAQGKPVSMEWALKSLAMDMVSQFAFGQSLNALADPEFKSLPVRVFQQYLPSLHVIKAFPFVRLLNSLPLWIAKRISHSVEMGHELEQFAARRIDEYMAAAAAGKTPTFPTLMERLLIPIPEKGYAVPDKQGLRDELLTVISAGDDTTGIANTVTLFNIFNNREVHDRLLAELKTVMPTPNSHVSYLQLEALPYLTAVIKEGLRYSSPAASRTPRLVPPGGVRLPDGRFIPAGTRVGMAIYHIHYNETLFESPRVFDPERWLQGPEVTAERAKFLVPFSRGSRSCLGINLAYMEMYMAIAYIVRRFDLDLVGTTEEDMKWDDMVVPQFHGEFMALTKRRED
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of macrophorins, isoprenoid epoxycyclohexenones containing cyclized drimane moieties (PubMed:28926261).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase macA (PubMed:28926261).  6-MSA is then converted to m-cresol by the decarboxylase macB (By similarity).  The cytochrome P450 monooxygenase macC then catalyzes the oxidation of m-cresol to toluquinol (By similarity).  Epoxidation of toluquinol is then performed by the short chain dehydrogenase macD, with the help of macE, and a further prenylation by macG leads to 7-deacetoxyyanuthone A (By similarity).  The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase macH to yield 22-deacetylyanuthone A (By similarity).  O-Mevalon transferase macI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (By similarity).  The terpene cyclase macJ catalyzes the cyclization of 22-deacetylyanuthone A to macrophorin A (PubMed:28926261).  MacJ is also able to catalyze cyclization of yanuthone E and 7-deacetoxyyanuthone A to their corresponding macrophorins (PubMed:28926261).  The macJ products can be further modified by macH and macJ, as well as by the FAD-dependent monooxygenase macF, to produce additional macrophorins, including 4'-oxomacrophorin A, 4'-oxomacrophorin D and 4'-oxomacrophorin E (PubMed:28926261).
What are the official names of this protein?
Cytochrome P450 monooxygenase macH, Macrophorins biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: QUEF_ALKCK
Sequence: MAGRQEKELQNVTLLGSEQTEYKYSYDPRVLETFDNQHPYRDYMVKFNCPEFTTLCPKTGQPDFATLYISYIPEQKMVESKSLKLYLFSFRNHGDFHEDSVNTIMNDLIELMDPRYIEVWGKFTPRGGISIDPYCNYGKKGTKYEEIANYRLMNHDLYPETITNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALPS_LIMPO
Sequence: DGIWTQLIFTLVKNLATLWQSGDFQFLDHECHYRIKPTFRRLKWKYKGKFWCPSWTSITGRATKSSRSGAVEHSVRNFVGQAKSSGLITQRQAEQFISQYN
What is the function of this protein?
Binds tightly to LPS and thus specifically inhibits the LPS-mediated activation of the hemolymph coagulation.  It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.
What are the official names of this protein?
Anti-lipopolysaccharide factor, anti-LPS, LALF.
Protein: ILVD_BUCAP
Sequence: MPKYRSFTTTHGRNMSGARSLWRATGMTDEDFKKPIIAIVNSFSQFVPGHIHLQEVGKIISKEIKKYGGVPKEFNTIAIDDGIAMGHSGMLYSLPSRELIADSIEYVINAHCVDSMICVSNCDKITPAMFMASLRLNIPSVFVSGGPMEAGKIKTKDKTKKIDLVDAIIHGGDSNKSDDFIREIELSACPTCGSCSGMFTANSMNCLIEAIGLSLPGNGTLLATHIDRKKLFKKSARNIVKITKDYYLNNNKNVLPRNIANKESFENAMALDIAMGGSTNTILHLLAAAYEGKVDFKMSDINNLSKKIPHICKVAPSTNLYHVEDVHRAGGVMRILGELNRSNLLNKKTENILGLNLEKTLKKYDILSTKNKNVIKMFHAGPGGNRTIKPFSQNYRWNKLDKDRVNGCIRSHENAYSKNGGLSVLYGNLAKNGCIIKTASIDKKHYIFSGPAKVYESQEEAVSAILSGKIIAGDVIVIRYEGPKGGPGMQEMLYPTTYLKSINLDKQCALITDGRFSGGTSGLSIGHISPEAANKGIIALVENGDDIQINIVNKTIHLNITEKELNLRIIKENAKGLKAYKPLNRKRNISFALRAYAHFALSADKGAIRNKKKLFNF
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PYRG_BORAP
Sequence: MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERFLNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETVRQIRHEVGSGNIAFIHLTYVPSPVGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKIAMFCNVESTSIIDNIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSRLVGIIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVHVAANLDLLIKSTLIDSNDLNESCLKDFDGIIVPGGFGGKGYEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLIKDKPLKNPVIHLLPEQKEIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFEKNGLIVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: APOD_MACFA
Sequence: MVMLLLLLSALAGLFGAAEGQEFRLGKCTSPPVQENFDPNKYFGRWYEIEKIPTTFEKGRCIQANYSLKENGKIKVLNQELRADGTVNQIEGEASPVNITEPAKLEVKFFWFMPSAPYWVLATDYENYALVYSCVSIINLFRVDYAWILARNRHLPSETVDFLKNILTSNNIDVKKMTVTDQENCPEFS
What is the function of this protein?
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase.  It is probably involved in the transport and binding of bilin.  Appears to be able to transport a variety of ligands in a number of different contexts (By similarity).
What are the official names of this protein?
Apolipoprotein D, Apo-D, ApoD.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAPSD_CMVO
Sequence: MDKSESTSAGRNRRRRPRRGSRSAPSSADANFRVLSQQLSRLNKTLAAGRPTINHPTFVGSERCKPGYTFTSITLKPPKIDRGSYYGKRLLLPDSVTEYDKKLVSRIQIRVNPLPKFDSTVWVTVRKVPASSDLSVAAISAMFADGASPVLVYQYAAFGVQANNKLLYDLSAMRADIGDMRKYAVLVYSKDDALETDELVLHVDIEHQRIPTSRVLPV
What is the function of this protein?
Capsid protein.  Probably binds RNA and plays a role in packaging (By similarity).
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: FABH_BURO0
Sequence: MAQSTLYSRVLGTGSYLPPDRVTNQQLTDRLAKEGIETSDEWIVARTGIHARHFAAPDVTTSDLALEASRRAIEAAGVDPQSIDLIIVATSTPDFVFPSTACLLQNKLGIKNGGAAFDVQAVCSGFAYAMATADSFIRSGQHRTALIVGAETFSRILDFKDRTTCVLFGDGAGAVILSASEEPGVLGSALHADGSYSNILCTPGNVNRGVIDGSAFLHMDGQAVFKLAVNVLEKVAIEALAKANLAPEQIDWLIPHQANIRIMTSTCRKLGLPQERMVVTVDQHGNTSAASIPLALDAAVRDGRIQRGQHVLIEGVGGGFTWGASVFRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
Protein: IF5A_PYRAR
Sequence: MSTKFVEVGELKEGSYVVIDGEPCRVVEIEKSKTGKHGSAKARIVAVGMFDGGKRTLSLPVDAQIEVPIIEKFTAQILSISGDIIQLMDMRDYKTIEVPMKYVEDEAKGRLAPGSEVEVWQILDRYKIVRVK
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYYR1_XENLA
Sequence: MDIPRSLRHPEILLVLLLSEITDICQAYCEADCKSYCCDGTPPYCCSYYAYIGNVLSGTAIAGIVFGIVFIMGVIAGIAICICMCMKSSRGTRVGVIRTTHINAISSYPAAPPPYSYEYEMDFPLDLPPPYTPTPPMSHYPSPPPYPGPSRK
What are the official names of this protein?
Cysteine and tyrosine-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the CYYR1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SYFA_MESFL
Sequence: MLKKINKIKDQFISDLNKVKTIEEAEKLKKSLLGKESELSEILKSLKDSDTNDKQAIGIASHELRTFIASTIDEFVARIKKEALDAKLASEKIDVSLTGTLARFGTKHPLNIVVEEITQIFTEIGFDVLNGNDVESDEYCFQKLNLPVGHPARDMQDTFYIDEETVLSTHCTHMTARVLTQMAKDENFEGNYACVAIGNVYRRDDDDATHSHQFMQLDLLCIGKKITFANLKWVLKYMCKRLFGEEVNIRLRPSLFPFTEPSVEVDVSCFKCSGKGCSICKYSGWIEILGSGIINEQVMLLNGMDPEKNTALAFGAGIERIAMLKFGISNIRNLYENNVQFLEQFKFYGE
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PORA_METJA
Sequence: METMCEVKVITGTSAAAEAAKLADVDVIAAYPITPQTTCVEKLAEFVANGELDAEYIKVESEHSAMSACIGAAATGARTFTATASQGLALMHEMLFIASGMRLPIVMMVANRALSAPINIWNDHQDSIAERDSGWIQIYVEDNQETLDSIIQAYKIAENEDVLLPVMVCLDGFILTHTVEPVTIPKAERVREFLGVYEPKHAYLDPDRPITQGPVGVPDCYMETRKQIEEAMERAKKVIRDVNEEFAEWFKRKYGNGLVEAYNLDNADTVLVAMGSVCGTIKYVIDELKKEGKNVGLLRIRAFRPFPKEDVKELLKDANNIAVLDKNISLGFNKGALGIEMASILKNKKVCNYIVGLGGRDIKIDDIKTIINHVEKAEDDSTLWVGLKE
What are the official names of this protein?
Pyruvate synthase subunit PorA, Pyruvate oxidoreductase alpha chain, POR, Pyruvic-ferredoxin oxidoreductase subunit alpha.
Protein: UPPP_AZOSB
Sequence: MDITLLLTALILGIVEGLTEFLPVSSTGHLIILGDLLGYNDEASKVFKIVIQLAAILAVCWDYRERLIKVAVGVPSDRSAQRFVGLLLLGFLPAAVLGFLFHSTIKNVLFNPLVVATALVVGGLIILYVEKRAYHPRVTSVDEMRWGDALKVGFAQALAMIPGTSRSGATIMGGLIFGLSRKTAAEFSFFLAIPTMLAATVYDVYKNWTLLRVEDLPVFAVGFVASFFAAMWAVKSFIRFISNHTFVVFAWYRIVFGIVVLATWQFDLVSWSTP
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_BURVG
Sequence: MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIVERMSGRRTHAASGRTYHVKFNPPKVEGQDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFEALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SH3R1_MOUSE
Sequence: MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVDELPSNILLVRLLDGIKQRPWKPGPGGGGGTTCTNTLRAQGSTVVNCGSKDLQSSQCGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVSGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDTAECPSATAQSTSASKHPDTKKNTRKRHSFTSLTMANKSSQGSQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPAFTFPSDVPYQAALGSMNPPLPPPPLLAATVLASTPSGATAAVAAAAAAAAAAGMGPRPVMGSSEQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWYKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVSMSTAGQASRGVTMVSPSTAGGPTQKPQGNGVAGNPSVVPTAVVSAAHIQTSPQAKVLLHMSGQMTVNQARNAVRTVAAHSQERPTAAVTPIQVQNAACLGPASVGLPHHSLASQPLPPMAGPAAHGAAVSISRTNAPMACAAGASLASPNMTSAMLETEPSGRTVTILPGLPTSPESAASACGNSSAGKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLDVELGAGEAPLQGAVGPELPLGGSHGRVGSCPTDGDGPVAAGTAALAQDAFHRKTSSLDSAVPIAPPPRQACSSLGPVMNEARPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.  In the absence of an external substrate, it can catalyze self-ubiquitination.  Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (By similarity).  Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway.  Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation.  Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells (PubMed:23963642, PubMed:27084103, PubMed:9482736).  Plays a crucial role in the migration of neocortical neurons in the developing brain.  Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (PubMed:22959435).
What are the official names of this protein?
E3 ubiquitin-protein ligase SH3RF1, Plenty of SH3s, Protein POSH, RING-type E3 ubiquitin transferase SH3RF1, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2.
What is the protein family that this protein belongs to?
Belongs to the SH3RF family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2 in lamellipodia. Colocalizes, with HERP1, in trans-Golgi network (By similarity).
Protein: GLRA3_MOUSE
Sequence: MAHVRHFRTLVSGFYFWEAALLLSLVATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDDEVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350).  Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity).  Plays an important role in the down-regulation of neuronal excitability.  Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310).  Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310).  Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350).  Plays a role in cellular responses to ethanol (By similarity).
What are the official names of this protein?
Glycine receptor subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes.
Protein: Y222_RICPR
Sequence: MLMYKKIVGHKKNMLPATLNNIDDSQNVALNRKKSENKKLTLQEKIELSWQFLYDLTEIILNKFSKEDVVQVNKCGQILFENGVRYEHVVDLITPHQVRSHTQLVEQEQSKGKKALRM
What are the official names of this protein?
Uncharacterized protein RP222.
Protein: ATG4A_ORYSJ
Sequence: MTSLPGRGVSPSSSDPLCEGNAAPSSSSSSGQDLKQLKNSILSCVFSSPFSIFEAHQDSSANRSLKPHSGSYAWSRFLRRIACTGSMWRFLGASKALTSSDVWFLGKCYKLSSEELSNSSDCESGNAAFLEDFSSRIWITYRKGFDAISDSKYTSDVNWGCMVRSSQMLVAQALIFHHLGRSWRKPSQKPYSPEYIGILHMFGDSEACAFSIHNLLQAGKSYGLAAGSWVGPYAMCRAWQTLVCTNREHHEAVDGNGNFPMALYVVSGDEDGERGGAPVVCIDVAAQLCCDFNKNQSTWSPILLLVPLVLGLDKLNPRYIPLLKETLTFPQSLGILGGKPGTSTYIAGVQDDRALYLDPHEVQLAVDIAADNLEAGTSSYHCSTVRDLALDLIDPSLAIGFYCRDKDDFDDFCSRASELVDKANGAPLFTVVQSVQPSKQMYNEESSSGDGMDSINVEGLDGSGETGEEEWQIL
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (By similarity).  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins (By similarity).
What are the official names of this protein?
Cysteine protease ATG4A, Autophagy-related protein 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_DECAR
Sequence: MSSIVDVIAREILDSRGNPTVEADVLLESGVMGRAAVPSGASTGTREAIELRDGDASRYLGKGVMQAVENVNTEISEAIIGLDAQEQAFIDQTMIDLDGTDNKSRLGANAILAVSMAVAKAAAEESGLPLYRYFGGMSPMQMPVPMMNIINGGEHANNSLDIQEFMVMPVGAANIREAIRCGAEIFHALKKLLNKKGHSTAVGDEGGFAPNLGSHAEALQIIMEAIEIAGYVPGQDVLLALDCAASEFYKDGKYKLAGEGLELTSAQFVDYLANLADQFPIVSIEDGMSEADWDGWKLLTDRLGDKVQIVGDDIFVTNTKIFKEGIKKGIGNSILIKINQIGTLSETFAAVEMAKRAGYTAVISHRSGETEDSTIADIAVGLNAGQIKTGSLSRSDRIAKYNQLIRIEEDLGDTASYPGRETFYNLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PXPA_ECOL6
Sequence: MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVFAQTLYQIGALAAITRAQGGVMCHVKPHGMLYNQAAKEAQLADAIARAVYACDPALILVGLAGSELIRAGERYGLVTREEVFADRGYQADGSLVPRSQPGALIENEEQALAQTLEMVQHGRVKSITGEWAMVTAQTVCLHGDGEHALAFARRLRATFAEKGIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.