PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_TROW8
Sequence: MPLDILQNRNNLLDVTSDEKQTEGALRPKLLAEFVGQNKVKNQLALLIQAAKIQGRVTDHALLAGPPGLGKTTLAMIVAAECGVSIRMSSGPAIQHAGDLAALLSSLLPGELLFIDEIHRMSRVAEEMLYLAMEDFRIDIMVGKGPGATSVPLELSPFTLVGATTRAGLLPGPLRDRFGFTARLDFYSPEELLQVLIRSARLMEIQYYDDALESIAVRSRGTPRVANRLLRRTRDYLLVSNSSEILSKEIALKAMDVYEVDSLGLDRLDRAVLHAIFDRFSGGPVGIKTLSAYLGEEAETIENSIEPFLVRQGLLVRTPRGRQITDLARKHMGFKEDLSGFELYL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SPIKE_BC279
Sequence: MKVLIFALLFSLAKAQEGCGIISRKPQPKMEKVSSSRRGVYYNDDIFRSDVLHLTQDYFLPFDSNLTQYFSLNIDSNKYTYFDNPILDFGDGVYFAATEKSNVIRGWIFGSSFDNTTQSAIIVNNSTHIIIRVCNFNLCKEPMYTVSKGTQQSSWVYQSAFNCTYDRVEKSFQLDTAPKTGNFKDLREYVFKNRDGFLSVYQTYTAVNLPRGFPAGFSVLRPILKLPFGINITSYRVVMTMFSQFNSNFLPESAAYYVGNLKYTTFMLSFNENGTITDAVDCSQNPLAELKCTIKNFNVSKGIYQTSNFRVTPTQEVVRFPNITNRCPFDKVFNASRFPNVYAWERTKISDCVADYTVLYNSTSFSTFKCYGVSPSKLIDLCFTSVYADTFLIRSSEVRQVAPGETGVIADYNYKLPDDFTGCVIAWNTAQQDQGQYYYRSYRKEKLKPFERDLSSDENGVYTLSTYDFYPSIPVEYQATRVVVLSFELLNAPATVCGPKLSTQLVKNQCVNFNFNGLRGTGVLTTSSKRFQSFQQFGRDTSDFTDSVRDPQTLEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVPTSIHADQLTPAWRVYSTGVNVFQTQAGCLIGAEHVNASYECDIPIGAGICASYHTASVLRSTGQKSIVAYTMSLGAENSIAYANNSIAIPTNFSISVTTEVMPVSIAKTSVDCTMYICGDSLECSNLLLQYGSFCTQLNRALTGIAIEQDKNTQEVFAQVKQMYKTPAIKDFGGFNFSQILPDPSKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALVSGTATAGWTFGAGSALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNDNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVSNGTSWFITQRNFYSPQIITTDNTFVAGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: ADPP_ECOL6
Sequence: MLKPDNLPVTFGKNDVEIIARETLYRGFFSLDLYRFRHRLFNGQMSHEVRREIFERGHAAVLLPFDPVRDEVVLIEQIRIAAYDTSETPWLLEMVAGMIEEGESVEDVARREAIEEAGLIVKRTKPVLSFLASPGGTSERSSIMVGEVDATTASGIHGLADENEDIRVHVVSREQAYQWVEEGKIDNAASVIALQWLQLHHQALKNEWA
What is the function of this protein?
Acts on ADP-mannose and ADP-glucose as well as ADP-ribose.  Prevents glycogen biosynthesis.  The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity).
What are the official names of this protein?
ADP-ribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, ASPPase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudF subfamily.
Protein: FGRL1_CHICK
Sequence: MGLQLALLLAGIVALSDSARGPPRIADKVIHRQSVRLGRTIKLLCPVEGDPPPLTMWMKDGRTIHSGWTRFRILQQGLKIKEVESEDAGTYICKATNGFGSTNVNYTLIVIDDTSSGKNSQTPEGSNGEYEDHSGKQWAQPRFTQPAKMRRRVIARPVGSSIRLKCVASGNPRPDITWLKDNKPLMPHEIGENKKKKWTLNLKNLKPEDSGKYTCRVFNKVGEINATYKVEVIQRTRSKPILTGTHPVNTTVDYGGTTSFQCKVRSDVKPVIQWLKRVEYGTESKYNSTIDVGGQKFVVLPTGEVWSRPDGSYLNKLMITRAKEEDAGMYICLGANTMGYSFRSAFLTVLPDPKPPSAPVPPSSVSSLPWPVIIGIPAGAVFIFGTILLWLCQTKKKPCSPPAAAPVHRPQPRDRICVSQVPDKDCISSINYEEYVAQQQHLLSQGPALAPAMASKMYPKIYTDIHTHTHSHVEGKVHQHQHIQYQC
What is the function of this protein?
Has a negative effect on cell proliferation.
What are the official names of this protein?
Fibroblast growth factor receptor-like 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RCE1_SCHPO
Sequence: MRVYLISFFFTAIYVVSLYTFPVARPRPSLNRNDPKVITARCISVLLASSVCCILTRLIIGPSLNVFTFPTDQVLKSLLHAATIFIGPLYEVWIVDKEYRLFFIHLKDCLSNAIAWRNIIIGPLSEELTFRCCIVPICEAAGWSRLKIIFVAPLLFGMAHIHHTYEFLLAYPNAYIAAALQTVVQFSYTTVFGWYTTHLFLSTHSLFPSFLVHAFCNSMGLPTLYGKIGNRNQTRIYYTLLLLGVLIFYMTWGITDFNNHQDFEPRLVPLN
What is the function of this protein?
Proteolytically removes the C-terminal three residues of farnesylated proteins.
What are the official names of this protein?
Probable CAAX prenyl protease 2, Prenyl protein-specific endoprotease 2, PPSEP 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase U48 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PYRG_PELTS
Sequence: MAKFVFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKLDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIDINISRSCNVTTGGIYAAVINKERRGEYLGGTVQVIPHITNEIKERVLSVADDSLADVVITEIGGTVGDIESQPFLEAIRQLKGDLGRGNVVYIHVTLVPYLRAANELKTKPTQHSVKELRSMGIKPDIIVCRSELPLSKEMEEKLALFCDVEKEAVIQALDAPSIYEVPLMLEEEGLADIVLDKLGIKTGPPDLADWREMVERMKNLRYLTTIALVGKYVSLQDAYLSVAEALRHAGFYHGSAIEIKWINSEEVNCANTEDLLGSADGILVPGGFGDRGIEGKIEAIRFARERGIPFFGLCLGMQLAVVEFSRNVIGWRGANSTEFDPYTPYPVIDLLPEQRQLSDKGGTMRLGSYPCKLVPGTLAYRAYKKEIVEERHRHRYELNNAYRADLAAKGLVFSGTLPDGYLVEIIELPGHPWFLATQFHPEFKSRPNRPHPLFRDFIGAARKYKESRYS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y1617_STAAT
Sequence: MENFDKTMKFDYEELPTQDVRDVLNNVYRTLDERGYNAVNQIVGYLLSGDPAYIPRQNEARNQIRHIDRDVIMEELVSYYLKEQNK
What are the official names of this protein?
UPF0297 protein USA300HOU_1617.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RL33_NATTJ
Sequence: MREKITLECTECKQRNYKSFKNKQNDRDRIELKKYCKFCNRHTLHKESK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: HFQ_NITOC
Sequence: MSRGQSLQDPFLNALRKERVPVSIYLVNGIKLQGQIESFDQFVVLLKNSVSQMVYKHAISTVVPARNVKLSSNEGENIHPIGGTRSADAD
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RL25_HELMI
Sequence: MLSGELRAIRREKGSRGYIKELRKRGLLPAVVYGKDKPDMLISVNAKELSGLLKAMGSASAILDLQVEGSDDRHKVMLKEMQRDPVGRMPNHVDFQLVDWNKPVHAEIPIHLVGTPAGVKAGGIIQHGLRTVEVEGLPGKLPPRFDIDISHLELHDKMTVADITSPAGIAIISEPDQVILSIIVPRAVLEPAESAPVLEENGDKGANGKANSNGKANGNGKANGDGEKAEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: TRMD_ALKOO
Sequence: MIIKVMTLFPEMFSGPLGNSIIQRAQENRILHIQCVNIRDYAENKHKKVDDYPFGGGPGMVMTPQPIVSCYESIVKEFQDKNHVEQPKVIYLSPKGKKFDQEMAERLSEENALILLCGHYEGIDQRVIDEIVTDEISIGDYVLTGGEIPAMVLIDAVARLIPGVLSQDASFEEESFYSGLLEYPQYTRPRVFRGRSVPDVLTSGNHSKIQEWRRNQSLELTFHRRPDLLKDFILTKKDQLFLEQIKSKK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTTG3_HUMAN
Sequence: MATLIYVDKENEEPGILVATKDGLKLGSGPSIKALDGRSQVSISCFGKTFDAPTSLPKATRKALGTVNRATEKSVKTNGPLKQKQPSFSAKKMTEKTVKAKNSVPASDDGYPEIEKLFPFNPLGFESFDLPEEHQIAHLPLSEVPLMILDEERELEKLFQLGPPSPLKMPSPPWKSNLLQSPLSILLTLDVELPPVCSDIDI
What are the official names of this protein?
Putative pituitary tumor-transforming gene 3 protein, hPTTG3, Securin-3, rcPTTG1.
What is the protein family that this protein belongs to?
Belongs to the securin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YXJG_BACSU
Sequence: MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAGEMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQGIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGKLEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAFGTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGLNLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRYVSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK
What are the official names of this protein?
Uncharacterized protein YxjG.
What is the protein family that this protein belongs to?
To B.subtilis YxjH.
Protein: RSXE_SALPC
Sequence: MSEIKDIVVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTVSALRRWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPWLSALDGFSIGMGATGAMFVLGSLREILGNGTLFDGADSLLGGWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAVKYLIDEKMKKRRAETAPSAVPAGETGKV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FIP1_NEUCR
Sequence: MDIDEDEDFYAPDEPQAAPPTTAATTTTPATTTTTAAPTTTTTTTSTTTASAPPTTTSSSTKPEDELEEGEEEDEGGGAMDEDDDSDIDIITERKDGSAPPPPVQSRYSEIRNIPQRAAANDNGVKTAPVKKSDGTNSNSNSSSNKFGGGGGIGNEQKTRQGSGAAGGSGAELPPVRTSKIEVDGIPVYKPVGKPITGVVIDEDLPENDKPWRKPGTDLSDYFNYGFDEFTWALYAQKQEALRGEYNAEAIAANNKKMMEEMTNMMMMGGMMPPGMGGPGGPGVGPAGPGAMGPGGPAGAGGMGGPGGGLDGMPPEMQAMMQQMMGAAAAQGMDPSQMGQMGMAGGPGDMGGMGGMFGGPGGGPGGPGTGGMGPGGPGGQGGQGQQFGGGFGGNQGQGGYGGYDQMGGAGGGGRGGRGRGRRW
What is the function of this protein?
Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.
What are the official names of this protein?
Pre-mRNA polyadenylation factor fip-1.
What is the protein family that this protein belongs to?
Belongs to the FIP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_RHOCA
Sequence: MAAKEVKFSTDARDRMLKGVNILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELADKFENMGAQMVKEVASRTNDEAGDGTTTATVLAQAIVREGMKAVAAGMNPMDLKRGIDLATTTVVEAIKAAARPVKDSDEVAQVGTISANGEAQIGRFIADASQKVGNEGVITVEENKGMDTEVEVVEGMQFDRGYLSPYFVTNPDKMIADLEDAYILLHEKKLSSLQPMVPLLEAVIQSTRPLIIVAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISDDLGMKLENVTLDMLGRAKKVTISKENTTIVDGHGDKAEINARVAHIRTQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDALNATRAAVQEGIIVGGGVALVQAAKKLNDLTGANSDQDAGISIVRRALEAPLRQIAENAGVDGAVVAGKVRESADPAFGFNAQTEEYGDMFGFGVIDPAKVTRTALEDAASIAGLLITTECMIAEKPEPKAAPAGGMGGMGGMDMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_PSET1
Sequence: MRVADFSFDLPDELIARFPKQDRTSSRLLSLDGPSGVVEHKVFSDLLELVNENDLLVFNNTRVIPARMFGQKASGGKVEVLVERVLDEHRVLAHVRASKSLKPGNEVILEGKAKATMVARHDTLFELEFEHSQNVLDILNDIGHMPLPPYIDRPDNEADRERYQTVYGEKPGAVAAPTAGLHFDDKLMTALKNKGVQMAFVTLHVGAGTFQPVRVATVDEHIMHSEYIEVPDDVVAAVANTKANGGRVIAIGTTSVRSLESAAKVHGGKLDTYFGDTDIFIYPGYQFNVVDAMITNFHLPESTLIMLVSAFAGQNNIMGAYNTAIEQQYRFFSYGDAMFLTRK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PROMA
Sequence: MSSETLYDKIWDLHRVAEIPGGSTQLFVGLHLIHEVTSPQAFSALNEKGLSVHCPERTIATVDHIVPTTSQNRPFPDSLAEQMLRTLELNCLKHSIKFFKIGSGNQGIVHVIAPETGLTQPGMTIACGDSHTSTHGAFGSIAFGIGTSQVRDVLASQTLAMKKLKVKRIWFDGYLQKGVFAKDLILHVIQKLGVKDGVGYAYEFAGPAIDGLSMEERMTICNMAIEGGARCGYINPDKTTFNYLKGRPYSPKGKEWEKAILWWESLASSKSAIYDDEVRFNASLIAPTVTWGITPGQSIAIDASIPTPESLDKNDQQIALEAYKYMDLKPGSSIEGIPIDVCFIGSCTNGRLSDLEKAAEIAKNRQVAKGVKAFVVPGSEKVAQDAESQGLDTIFEKAGFEWRKPGCSMCLAMNPDKLERNQISASSSNRNFKGRQGSAQGRTLLMSPAMVAAAAVTGSITDVRKLLH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: TO1D_ATRRO
Sequence: MNTATGVIALLVLATVIGCIEAEDTRADLQGGEAAEKVFRRSPTCIPSGQPCPYNENCCSQSCTFKENENGNTVKRCD
What is the function of this protein?
Insecticidal toxin that reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels (Cav) in cockroach DUM neurons.  Also causes a modest block of insect sodium channel currents (Nav).  Induces potent excitatory symptoms, followed by flaccid paralysis leading to death in house crickets (By similarity).
What are the official names of this protein?
Omega-hexatoxin-Ar1d, Omega-HXTX-Ar1d, Omega-atracotoxin-Ar1d, Omega-ACTX-Ar1d.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 01 (omega toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS6_LEVBA
Sequence: METTKYEITYIIRPDLDDAAKTALVERFDKILTDNGAELINSKDWSKRRFAYEIGGFNEGIYHVITLNATDDKGLNEFDRLAKINDSILRHMIVKRED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RS7_CLOBK
Sequence: MPRKGHIAKRDVLPDPLYNSKVVTKLINSIMLDGKRGVAQKICYDAFEIIGEKSGKDAMEVFETAMNNIMPLLEVKARRIGGATYQVPIEVRPERRQTLGIRWMLIAARKRGERSMRERLAGELLDASNNTGAAVKKREDTHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: T4S4_PONAB
Sequence: MCTGGCARCLGGTLIPLAFFGFLANILLFFPGGKVIDDNDHLSQEIWFFGGILGSGVLMIFPALVFLGLKNNDCCGCCGNEGCGKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVLCAIQVVNGLLGTLCGDCQCCGCCGGDGPV
What is the function of this protein?
Regulates the adhesive and proliferative status of intestinal epithelial cells.  Can mediate density-dependent cell proliferation.
What are the official names of this protein?
Transmembrane 4 L6 family member 4.
What is the protein family that this protein belongs to?
Belongs to the L6 tetraspanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PNP_RALPJ
Sequence: MTMFNKVVKEFQWGGHKVRMETGEIARQASGAVLLDMDDTVVLATVVGAKNPKPGQDFFPLTVDYLEKTYAAGKIPGGFFKREGRPSENETLTSRLIDRPLRPLFPEGFYNEVQVVIHVLSINPEVPADIPALVAASAALAVSGLPFNGPVGAARVGYKDGQYLLNPNRAQLAHSDLDLVVAGTERAVLMVESEAQQLSEEIMLGAVVYGHEQMQIAINAIHDLVRDGGKPEWDWQAAPKNEALVAKVSELGLADLQAAYQLRQKSARSQKLKEVYKSVAAKLAEAGVEADGVEVDNILFELESKIVRGQILNGEPRIDGRDTRTVRPIEIRSSVLPRAHGSSLFTRGETQALVVAALGTKSDEQIIDALQGEYRDRFMLHYNMPPFATGETGRVGSPKRREVGHGRLAKRALIPVLPPADEFGYTIRLVSEITESNGSSSMASVCGGSLALMDAGVPIKAHVAGVAMGLILEDNKFAVLTDILGDEDHLGDMDFKVAGTDAGITALQMDIKVQGITKEIMQVALAQAKEGRLHILGKMQAAMGGARTELSEHAPRMITVKINPEKIRDVIGKGGSTIQALTKETGCTIDIGEDGTITIASTSSEGMAEAKRRIEGITAEAEVGKIYNGTVLKLLDFGAIVNILPGKDGLLHISEIANERVNQVSDYVKEGQAVRVKLLSTDEKGRMRLSIKAAKAEEGDVPVAAPQAPGAGDAASQQQQQQQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_YERPB
Sequence: MSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: BDS1_ANTEL
Sequence: GTTCYCGKTIGIYWFGTKTCPSNRGYTGSCGYFLGICCYPVD
What is the function of this protein?
Peptide with both antimicrobial and neurotoxin activities.  This toxin acts both on ERG potassium channels and sodium channels (PubMed:12815161, PubMed:16497878, PubMed:17473056, PubMed:22972919).  It potently and reversibly inhibits human Kv11. 1/KCNH2/ERG1 (IC(50)=34 nM) (PubMed:12815161, PubMed:16497878, PubMed:17473056), rat Kv11. 1/KCNH2/ERG1 (PubMed:16497878) and Kv11. 3/KCNH7/ERG3 (PubMed:17473056) voltage-gated potassium channels in a similar potency.  It acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses (PubMed:12815161, PubMed:17473056).  On sodium channels, it blocks Nav1. 2/SCN2A (EC(50)=31 nM), Nav1. 3/SCN3A, Nav1. 4/SCN4A, Nav1. 5/SCN5A, Nav1. 6/SCN8A, Nav1. 8/SCN10A (EC(50)=92 nM) (PubMed:22972919).  It may act by binding at site 1 or close by, only when the pore is in an open configuration (PubMed:22972919).  Shows antibacterial activity against the Gram-negative bacterium S. typhimurium, but not on the bacteria B. subtilis, S. aureus, and P. aeruginosa (PubMed:28796463).  In vivo, this toxin does not induce neurotoxic symptoms when injected into mice (PubMed:12815161).
What are the official names of this protein?
Kappa-actitoxin-Ael2a, Kappa-AITX-Ael2a, Toxin APETx1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: HCP_CLOB6
Sequence: MSMFCYQCQEAAGGRGCTVKGVCGKTEDIAKTQDLIIYVVKGIAIYSSQAREMGLNTSEADKFIVESLFSTITNANFDAKALNSRVQKGLKIRQSLKDDIIKAGGSYNSKENKSWTSKFLSVLGIKNDKDEKEIHDAAIWAANNPEDFKKKAETVGVLATENEDIRSLRELLTYGLKGMAAYLEHANNLGYAEDSIHAFMEKALVATLDDTLSADELTALVLECGKYGVDVMALLDKANTSTYGNPEITKVNIGVRNNPGILISGHDLKDMEELLKQTEGTGVDVYTHSEMLPANYYPAFKKYKHFVGNYGNAWWKQNEEFEAFNGPILMTTNCIVTPKASYKDRMYTTGVTGFEGVKHINPSKDGKKDFSEIIEHAKRCASPKEIEKGEIIGGFAHNQVLALAPQVVDAVKTGAIKRFFVMAGCDGRMKSRNYYTDFAKALPKDTVILTAGCAKYKYNKLDLGDINGIPRVLDAGQCNDSYSLAVIALKLKEVFELEDINELPISYNIAWYEQKAVIVLLALLHLGVKNIHLGPTLPAFLSPNVAKILVENFGIGTISSVDEDIKMFMN
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_YERPA
Sequence: MSVIKMTDLDLAGKRVLIRADLNVPVKEGKVTSDARIRASLPTIEAALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKEKLSSPVRLAKDYLDGVEIAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVYVMDAFGTAHRAQASTHGVGKFAPIACAGPLLSAELEALGKALGNPARPMVAIVGGSKVSTKLTVLGALSKIADKLIVGGGIANTFVAAQGHNVGKSLYEADLIPEAKRLLETCDIPVPTDVRVATEFSETAAATLKPANEIKDDEQILDLGDESAERLAEILKNAKTILWNGPVGVFEFPNFRKGTEIVARAIAESEAFSIAGGGDTLAAIDLFGIADQISYISTGGGAFLEFVEGKKLPAVVMLEERAKQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO_ICTPU
Sequence: MVVHIENLNAFSAALKNAGDKLVVVDFTATWCGPCQKIGPIFETLSKSEDYQNVVFLKVDVDDAADVSSHCDIKCMPTFHFYKNGQKIDEFSGANEQTLKQKINDHK
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).  Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide.  Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.  Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Shuttles between the nucleus and nucleolus.