PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_ESCF3
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVVTEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPSIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFEEMKAEALAMGFTHAACGPFVRSSYHADLQAKGIEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS16_HUMAN
Sequence: MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELRDCLVAAAPYGGPIALLRNPWRKEKAASVRPVLDIYSASGMPLASLLWKSGPVVSLGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAHRFTLSANVGDLKLRRMPEVPGLQSAPSCWTVLCQDRVAHILLAVGPDLYLLDHAACSAVTPPGLAPGVSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWCSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPAASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLTQAVQQCIEAAGHEHQPDMQKSLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAVRDYHIGIPLTYSQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNEAELSLVLSHCTGATDGATADKIQRARAQAQKK
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203).  Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104).  Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203).  The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 16 homolog, hVPS16.
What is the protein family that this protein belongs to?
Belongs to the VPS16 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome. Note=Colocalizes with AP- 3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Protein: KGX44_CENEX
Sequence: DRDSCVDKSKCAKYGYYYQCDECCKKAGDRAGTCEYFKCKCNP
What is the function of this protein?
Reversibly blocks Kv11/ERG potassium channels.
What are the official names of this protein?
Potassium channel toxin gamma-KTx 4.4, CexErgTx3, CexErg3, ErgTx3, Ergtoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 4 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCF12_ANEMR
Sequence: MNLEVIAQPIVLGLIVASGPLVIVSLAARRGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: LEGL_DANRE
Sequence: MAELSAVRQELRSRNLSSSFGELQSPQRDEQKLAVPFCGGIRGGLRPGKKITIMGVVSADPDSFDISLTCGCADVALDMCVRFEEREILRNACVSDQWGDEERSIPYFPFIAEQPFRVEIHCEHPRFLVLVDGHQLFDFYHRVMPLNAIDTIQISGSLTITKLN
What is the function of this protein?
Does not bind lactose, and may not bind carbohydrates.
What are the official names of this protein?
Galectin-related protein, Lectin galactoside-binding-like protein.
Protein: Y2067_MYCTU
Sequence: MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHRILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLANLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKYGRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDTFLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAWSVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGWRMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFVAVALPASG
What are the official names of this protein?
Uncharacterized protein Rv2067c.
Protein: ISL2B_DANRE
Sequence: MVDIIFSSSFLDDMGDHSKKKSGLAMCVGCGSQIHDQYILRVSPDLEWHAACLKCVECNQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCTLGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSVRDEELLCRADHGLALERGPGGSPLSPGNIHTRGLHMAADPVSVRQTPHRNHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQLQQQHGDKTNLQGMTGTALVAGSPIRHNPSVPGHPVDVQAYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
What is the function of this protein?
Binds to one of the cis-acting domain of the insulin gene enhancer.  May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron.
What are the official names of this protein?
Insulin gene enhancer protein isl-2b, Islet-2B, Insulin gene enhancer protein isl-3, Islet-3.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCR_ONCMY
Sequence: FKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRVRKCLQAGMNLGARKSKKPGKLKGVNEDSTPTKEGGQTCPGSGGGYLSSGEKELSTSPTNALVPHGPGGGLVTPYLPPSICSVLELIEPEVVFAGYDNTQPDTTDHLLSSLNQLAGKQMIRVVKWAKVLPGFRGLPIEDQITLIQYSWMCLSSFSLSWRSYKHTNGQMLYFAPDLVFNEDRMQQSAMYDLCLGMRQVSQEFVRLQLTYQEFLSMKVLLLLSTVPKEGLKNQAAFEEMRVNYIKELRRSVGKAPTTLDRRGNRSSQLTKLLDAMHDLGGELLDFCFYTFRESQALKVEFPEMLVEIISDQIPKVESGNTHTLYFHKK
What is the function of this protein?
Receptor for both mineralocorticoids (MC) such as cortisol.  Binds to mineralocorticoid response elements (MRE) and transactivates target genes.  The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
What are the official names of this protein?
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding.
Protein: SYS_DESVM
Sequence: MLDLKLLQRSPEVVAKALADRGSSLDMAEFTALDERRRALLAEVEALKGERNKASGEVARMKRAGEDAAPLLERLSGLSDRIKDLDRETEEVKAAVNDWLLAVPNIPDASVPFGRSEADNPEVLRWGEPRAFSFAPKEHWEIGTALGGLDFERAGKLAGSRFAVYRTWAARMERALANFFLDTHVTEHGYVEIIPPFMVNRKTMTGTGQLPKFEEDLFKLEGWDYFLIPTAEVPLTNLHADDVLEEAQLPMGYAAMTPCFRSEAGSYGKDTRGLIRQHQFTKVEMVRFAHPERSFDELEKMRGHAEVLLQRLGLPYRVITLCTGDMGFSSAKTYDIEVWLPGQNAYREISSCSNCGDFQARRAGIRFRPAGGGKPEFAHTLNGSGLAVGRALVAVIENYQQEDGSVVIPEVLRPYMGGMERVTAE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_EHRRG
Sequence: MQGTVNSERLKFDAEVGKVLKLVIHSLYTNKDIFLRELISNASDACDKLRYQSLSNQDLMDAGSELKIVISVDKDKNRLYISDNGIGMNREDLINNLGTIAHSGTQKFLDAINSGASSQQGVVELIGKFGVGFYSAFMVASEVIVESCKAGESVGYQWKSSGDGEFVISQLESDQVSRGTRITLALKPEECEFVDKFRIEHIVTTYSYHINYPVYFLNDKGEEERLNSEAAIWTKAKDEISAEEHQNFFRTVAHVGGEPWMILHNKNEGVIEYTNLLYIPSIKPFDLFHPDRKCSVKLYVNKVFITEDNVQIIPQYLRFLKGIIDSSDLPLNISRETLQNNKIIEKIKRSLVKRVLSELKKKAESNIEDYTKFWDNFGSVLKEGLCESMNTEFREELISVCRFYSTHSNDSLISLEDYIERMKPEQNNIYYLTGNDLDSIKKSPQLEGFVSRGVEVLLLVDPVDDFWTNVVTDYQKVPLRSVIRADEDLEKFSDVEKGDESKDSQNEDTQSKEKVDKFIGYAAQVLNNLVSNVRVSKKLTDSPVCLAVADGSMDIRMERFLREQKQLNYKSTKILEINSKHPIISKMIDQYTENGESAMLCNMLHLLLGQACILEGEELQNVSDFAERMNSVLSQIN
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_BACC2
Sequence: MSSFTHFNDQGRAKMVDISDKKATVRTAIACSSIVVTKEIYDKISHNEIGKGDVLAVAQIAGIMAAKRTSDIIPMCHPLLLKGVDVSFDWKQSEEQYRLLIEVKVKTEGSTGVEMEALTAASATALTVYDMCKAVDKGMIIGETYLLEKTGGKSGDYTRNS
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: VAPC1_METJA
Sequence: MKILKKLKKKLEKEESKILVDTSVLIDYFKKRRLEELGGEAISIITAVEFIRGISEHKQEQVLNIFKELFEIVYIDEEIIIPFSKIYRQLKKRGMLIDDADLYIACTAIIKNYPLWTKNKKHFERLKEFGLKIYDK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  Its cognate antitoxin is VapB1 (By similarity).
What are the official names of this protein?
Ribonuclease VapC1, RNase VapC1, Putative toxin VapC1.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: MGSA_BRUA4
Sequence: MTERLRIALIAHDQKKDDMVAFAKAHEQALARFDIVATGTTGSLILDACPSLSIQRVKSGPLGGDQQIGAMIAEGTVEVLIFFIDPLSPLPHDVDVKALTRLGSVYDIPMALNRATAEKLIKALD
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PRIB_SHEB9
Sequence: MTTNNLVLSGTITRSRRFKSPAGIAHSVIMLEHKSQRYEADMLRNVYVQIQVILSGPRFESVAEDLKAGVEVQVQGFMTLQQGRNGQNRLVIHAENVELKT
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: RS3_FRATT
Sequence: MGQKVNPNGIRLGYIRDWRSTWYADSSRYATKLNEDIKVREFLHKKLAAAAVSKIQIERPAQNAKITIHTARSGIVIGKKGEDVEKLRAEVHKLMGIPVQINIEEVRKPEIDAKLVAESVAQQLEKRVMFRRAMKKAMQAAMKSGAKGIKIMVSGRLGGAEIARSEWARDGRVPLQTFRADVDYATAEALTTYGVIGVKVWIYKGEILPGQIAEKKNNKKRS
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MDH_ACTP7
Sequence: MKVALLGAAGGIGQTLALLLKLRLPVGTDLALYDISPVTPGIAVDISHIPTSVSAVGYSGEDPSEALKGANLVIITAGVARKPGMTRADLFNINADIVKNLVEKVAEVCPKACIGIVTNPVNTLVPIAAEVLRKAGVYDKRKLFGVTTLDVVRAKTFTSELKEKHVETVKVPVIGGHSGPTILPLLSQALSEGLPLSFTQEEIEALTYRIQNAGTEVVEAKAGGGSATLSMAESGARFAVAVFKALLGEDCVRYAYVESKEGSGYPEFFAHPVRFGLTGVEELLPIGKLSEYEQAKLDELKPVLEADIALGKNFVNP
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: NHRF4_MOUSE
Sequence: MEAAADLRDTALLTLKFKFNPRLGIDNPVLSLAEDQDQSDPWNLHRPRFCLLSKEEEKTFGFHLQQHLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNIVAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHVVKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNRKLWQSGDQVTLLVAGLEVEEQCHQLGMPLAAPLAEGWALPAKPRCLNIEKGPEGFGFLLREEKGLDGRLGQFLWDVDPGLPADKAGMKAGDRLVAVAGESVDGLGHEETVSRIRAQGSCVSLIVVDPEADRFFSMVRLSPLLFLENTEIAAPPLAETKDLPVEDTVEPSGLAGSCQCFLYPGPGGGYGFRLCCVASGPCLFISQVTPGGSTARAGLQVGDTVLEVNGYPVGGDSELDRLQQLTEAEPPLCLKLGARNPQGLEAWISLESGEDWTLASELL
What is the function of this protein?
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity).  Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity).
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm. Note=In kidney, predominantly localized to the subapical compartment of proximal tubular cells (PubMed:11099500). In intestinal epithelial cells, localizes to the ileal brush border and in a juxtanuclear compartment (PubMed:19088451). Expressed in the membrane, with relatively low expression in the cytoplasm (PubMed:26756164).
Protein: SYC_ANADF
Sequence: MPIVISDTLTGTKRELQPIEPGKIRFYACGPTVYDSAHVGHGRSYVVWDLVVRHLRARGYEVRYVRNFTDVDDKIIRRATERREDPVALAARYAREFDEDMDALGNLRPDVAPKVSEHVPQIVAMISSLVEKGFAYAAANGDVYFSVRAFPDYGRLSKRNLDDLLSGARVEPGEAKRDPLDFALWKAAKPGEPTWDSPWGGGRPGWHIECSAMTLAHLGVPIDLHGGGKDLVFPHHTNEIAQSAAAVGDGRTAESFCRHWMHHGFVEIDSEKMSKSLGNFFTLRDVLAKFDAEGVRLFYLGTHYRNPINYSDAILAEAERRLNYFYETLEKVDALAEGTSPAGEGGGVVEDARRALDDDFNAPQVLAVLAEAFTAANALADKRGKKTPEDRARLAAFARDVREIGTTLGLVQRRPAEALRAIRARAAARRGIDPASVEAKIVERAEARRARDFARSDAIRDALLAQGVALMDGPQGTTWKVE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAB_SYNE7
Sequence: MATKFPKFSQDLAQDPTTRRIWYGIATAHDFESHDGMTEENLYQKIFASHFGHLAIIFLWVSGNLFHVAWQGNFEQWSQDPLHVRPIAHAIWDPHFGQGAIDAFTQAGASSPVNVAYSGVYHWWYTIGMRTNGDLYQGSIFLLILSALFLFAGWLHLQPKFRPSLSWFKNAESRLNHHLAGLFGFSSLAWTGHLVHVAIPEARGQHVGWDNFLSTLPHPAGLAPFFTGNWSVYAENPDTASHAFGTAEGAGTAILTFLGGFHPQTEALWLTDIAHHHLAIAVIFIIAGHMYRTNFGIGHSIKEILEAHKPPAGGLGAGHKGLYETLNNSLHFQLALALASLGVVTSLVAQHMYSMPPYAFIAKDYTTMAALYTHHQYIATFIMCGAFAHGAIFLIRDYDPEANKNNVLARVLEHKEAIISHLSWVSLFLGFHTLGLYVHNDVVVAFGTPEKQILIEPVFAQFVQAASGKALYGFNVLLANADSAATAASLGTYLPNWLDAINSGKTALFLPIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWALNTVGWVTFYWHWKNLTVWQGNVAQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGTNNLSVWSWMFLFGHLIWATGFMFLISWRGYWQELIETIVWAHQRTPLANIVGWKDKPVALSIVQARVVGLAHFTVGYFLTYAAFLIASTAGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PCDG5_PANTR
Sequence: MASPPRGWGCGELLLPFMLLGTLCEPGSGQIRYSMPEELDKGSFVGNIAKDLGLEPQELAQRGVRIVSRGRTQLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVIGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSLSEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLVTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVPENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVEDHGQPPLSATVTVTVAVADRIPDILADLGSIKTPIDPEDLDLTLYLVVAVAAVSCVFLAFVIVLLVLRLRRWHKSRLLQAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLLSEESCEKSEPLLMSDKVDANKEERRVQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-A5, PCDH-gamma-A5.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GCH1_STRP2
Sequence: MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVIIEAEHMCMSMRGVRKPGTATLTTVARGLFETDKDLRDQAYRLMGL
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: CING_PAPAN
Sequence: MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQEASGALGSDFELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSQSQASLAGPGPMDPSNRSTSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQSRGRTGRRTRMLPPEQRKRSKSLDSRLPRDTLEERERQSTNHWTPSTKYDNHVGSSKQPSQSQSPSPPSGFSRSRQTQDWVLQSFEEPRGRAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMISSGSTKAVAGQGELTRKVEELQRKLDEEVKRRQKLEPSRVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEGLRHGLEAQVMELQNKLKQVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLQTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAAVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKHLLDRTVDRLNKELEKIGEDSKQALQQLQAQLDDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELLQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRELEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKHEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC
What is the function of this protein?
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
What are the official names of this protein?
Cingulin.
What is the protein family that this protein belongs to?
Belongs to the cingulin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Note=Localizes to the apical junction complex composed of tight and adherens junctions. Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells.
Protein: THIM_CUTAK
Sequence: MPAKGVVDMTELSNLVAESLERLRRDKPLVQCLTNIVVANFTANVLLSAGAVPAMVDNPEESEGFASIADGVLVNTGTPYRETTEAMIAAARGAASSNTPWVLDPVGVGMSWRTRVVLDTLDVAAPAVIRANASEVLALAGTGASSRGPEAGDAVEDALASATQLVRHYGCVVAISGPVDHILDADRHVTVSSGHEWMTRVTGVGCSLGALTAAFAGIQNDHLIAAVSATAMLCVVAERAAERSAGPGAFAQALVDELFLVSPDEVGERGGLRDVTA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MRGX2_TRAFR
Sequence: MDPTTLVWGTESTTMNGNDQALPLLCGKETLILVVLILFIALVGLVGNAFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFPMINCLAYLINFFHSISINFPSFFTTVMTCAYLAGLSMLSAISTERCLSVLWPIWYRSRRPRHLSAVMCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLMFLFVVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLIFLLCGLPFGIQWFLILWIWKNSDVLFCHIHPVSVVLSSFNSSANPIIYFFVGSFRKQWRLRQPVLKLALQRALQDTAEVDHSEGCFSQGTLEMSGSSLV
What is the function of this protein?
Mast cell-specific receptor for basic secretagogues, i. e.  cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core.  Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium.  In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.
What are the official names of this protein?
Mas-related G-protein coupled receptor member X2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRC46_HUMAN
Sequence: MSGGKSAQGPEEGGVCITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPVVERWISDEEDEASSDEEFPELSGPFCSERGFLKELEQELSRHREHRQQTALTEHLLRMEMQPTLTDLPLLPGVPMAGDSSPSATPAQGEETVPEAVSSPQASSPTKKPCSLIPRGHQSSFWGRKGARAATAPKASVAEAPSTTKTTAKRSKK
What are the official names of this protein?
Leucine-rich repeat-containing protein 46.
Protein: LEG10_PONPY
Sequence: EPYLQVDFHTEMKEESGIAFHFQVHFGCYVVMNSREYGAWKKPVESKNMPFQDGQEFDLSISVLPDKY
What is the function of this protein?
Regulates immune responses through the recognition of cell-surface glycans.  Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) (By similarity).
What are the official names of this protein?
Galectin-10, Gal-10, Charcot-Leyden crystal protein homolog, CLC.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Protein: SUCC_ECO57
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKGLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.