PharMolix/UniProtQA huggingface dataset:
Protein: PYRI_ECO8A
Sequence: MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: HIS8_AZOC5
Sequence: MSVSAKETQRHPARPEPRPGVLAISAYVPGKSHAAGVEKVFKLSSNETPLGPSPKAIAAFQSAGTNLQDYPDGSSTALREAIGKAMGIDPDRIICGAGSDEILNLIAHAYVGPGDEAIHCAHGFLVYKIATLGAGGVPVVVPDREDLQMDVDAIIGAVTERTRVIFLANPNNPTGTYLPFNEVRRLHAALPPNVLLVLDAAYSEYVRRNDYETGLELALSAENVIMCRTFSKIHGLAALRIGWAVASEAVIDALNRIRGPFNMNAPAIAAGAAAILDAEHVERSIAHNDQWLSWLTTELTALGLTVTPSVGNFVLIHFPKTPGRTAAEADAFLTRRGLILRAVASYGLPDSLRMTIGTEEANRLVVQALSDFLSGAER
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: Y380_BACCZ
Sequence: MDLSVKSEENVEYMVEAIKEKLRMVNAGAMRAASFNEEMYEDLRDIYEHVMKRETFSISEMQAITEELGTLIKK
What are the official names of this protein?
UPF0435 protein BCE33L0380.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: AROK_ECODH
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDLEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLHVETPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNPC5_BOVIN
Sequence: MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRREGEMLPSQPAPEPSHDMLVHVDNEASINQTALELSTRSHVQEEEEEEEEEEEDS
What is the function of this protein?
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes.  Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes.  Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).
What are the official names of this protein?
snRNA-activating protein complex subunit 5, SNAPc subunit 5, Small nuclear RNA-activating complex polypeptide 5.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPRT_PSEPK
Sequence: MPEQLKQRVETCYQQAEAFFKRRFPRPEVSFKLRGQKAGVAHLHENLLRFNLQLYRENQEDFLRQTVAHEVAHLVAHQLFGDRIQAHGEEWQLIMRGVYELPPNRCHNYDVQRRAVTRYIYRCPCPQSDFPFTAQRHKLVHQGRRYLCKRCREVLVYSGETRVE
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUMC_WIGBR
Sequence: MLINRIEKDTIGEVELPKKCLWGSQTQRSIYNFNISTEKMPYELIHALVQIKLVAAKVNKDLKLLEEKKADAIIKASEEILSGKYKDSFPLVIWQTGSGTQTNMNVNEVIANIAIKLLGGKYGDYSIIHPNDHVNKSQSSNDVFPTAMHISAVLSLKKNLLPNLIKLKKSFYDKSILFKDIIKIGRTHLQDATPLTLGQEVSSWYCMLKKNIKYIKNSILCISEIALGGTAVGTGLNAHEKYSLKASKLLSEINKHNFISSTNKFESLSTCDAIVKVHSTLKNLSISIMKISNDIRWLSSGPRCGIGELIIPENEPGSSIMPGKVNPTQCESISMICCQVIGNDSAIGIGGLSGNFQLNVFRPMIIYNFLQSVRILSDGIKSFNKKCVIGIKPNIKRIKKFLKESLMLVTSLTPHIGYDKSAKIAKLAHNENITLKEACLKLNYISESQFDILVRPENMIGNKN
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIG_JANSC
Sequence: MTAAPDATGTVNTVDAGEVAKFEAMAAEWWDLEGKFKPLHMLNPTRLDYITQQIAAEFGRDLKADAPFAGLHILDIGCGGGLLAEPMARLGADVVGADAAERNIPVAQVHAAQSGLEIDYRHTTAEAMADAGEQFDVVLNMEVVEHVVDPLGYLTACQRLLKPGGLMVCSTLNRNPKSYLMAIIGAEHVMRWLPKGTHEWSKFITPDELFDLIRQAGLDPVDRKGFVFNPLLWTWGISERDMSVNYVTASVKQV
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: OAT_BACCQ
Sequence: MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTARRWAYDVKKVEANRAEIIVCEDNFHGRTMGAVSMSSNEEYKRGFGPMLPGIVVIPYGDLEALKAAITPNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGRTGKVFACDWDGVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAGLLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase, OAT, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2AH_TAXCA
Sequence: MDAMDLTVAKFKEFTQLQSSAILLTVVSGIIVIVILLLRSKRRSSLKLPPGKLGLPLIGESLSFLWALRSNTLEQFVDKRVKKYGNVFKTSLLGQPTVVLCGAAGNRLILSNQEKLLSRTVSDRVAKLTGDTSISVIAGDSHRIIRAAVAGFLGPAGLKIHIGEMSAHIRNHINQVWKGKDEVNVLSLARELVFAISASLFLNINDREEQHQLHKTLETILPGYFSVPINFPGFAFRKALEGNSKRRKHFSVLQEKRRRDLSVGLASRTQDLLSVLLAYEDDKGNPLTDEEVLDNISALIDGSYESTSSQMAMLLKLLSDHPECYEKVVQEQLEIASHKKEGEEITWKDVKAMRYTWQVMQETLRMFAPVFGPRGKAITDIHYDGYTIPKGWQLSWATYSTHQNDTYFNEPDKFMPSRFDEEGGRLAPYTFVPFGGGRRKCPGWEFAKTEILLFVHHFVKTFSAYTPIDPHESIWGRPLPPVPANGFPIKLISRS
What is the function of this protein?
Catalyzes the conversion of taxusin to 2-alpha-hydroxytaxusin in taxol biosynthesis (PubMed:15178487).  Catalyzes the conversion of 7-beta-hydroxytaxusin to 2-alpha-7-beta-hydroxytaxusin in taxol biosynthesis (PubMed:15178487).
What are the official names of this protein?
Taxoid 2-alpha-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: NTRC_AZOBR
Sequence: MSAATILVADDDRAIRTVLTQALARLGHEVRTTGNASTLWRWVADGQGDLIITDVVMPDENGLDLIPRIKKIRPDLRIIVMSAQNTLITAVKAAERGAFEYLPKPFDLKELVSVVERALNSNTPPAALPADAGEADEQLPLIGRSPAMQEIYRVLARLMGTDLTVTITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRELIESELFGHEKGAFTGATNRSTGRFEQAQGGTLFLDEIGDMPLEAQTRLLRVLQEGEYTTVGGRTPIKTDVRIVAATHRDLRTLIRQGLFREDLFYRLCVVPIRLPPLRERTEDVPLLVRHFLNQCSAQGLPVKSIDQPAMDRLKRYRWPGNVRELENLVRRLAALYSQEVIGLDVVEAELADTTPAAQPVEEPQGEGLSAAVERHLKDYFAAHKDGMPSNGLYDRVLREVERPLISLSLSATRGNQIKAAQLLGLNRNTLRKKIRDLDIQVVRGLK
What is the function of this protein?
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation.  Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
What are the official names of this protein?
DNA-binding transcriptional regulator NtrC, Nitrogen regulation protein NR(I), Nitrogen regulator I, NRI.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTURN_XENTR
Sequence: MDFQQLADVADKWCSNTPFDLIATEETERRMDFYADPGVSFYVLCPESGCGDHFHVWSESEDCLPFLQLAQDYISSCGKKTLHEILEKVFKSFRPLLGLPDVDDDTFEEYNADVEEEEPEADHQQMGVSQQ
What is the function of this protein?
Involved in early neuronal development; required for cell cycle exit and differentiation of primary neurons (By similarity).  Cooperates synergistically with pak3 to promote primary neural differentiation within the neural plate (By similarity).  May play a role in promoting megakaryocyte differentiation (By similarity).
What are the official names of this protein?
Maturin, Maturin neural progenitor differentiation regulator protein.
What is the protein family that this protein belongs to?
Belongs to the MTURN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_SHESW
Sequence: MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLICRGDRAIPANERAKISLFCNVEERAVISLKDVDSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIELPDAYKSVNEALKHAGLKNRVSVTIKYIDSQTVEAKGDEVLQGLDGILVPGGFGERGVEGKILAAKFARENKLPYFGICLGMQVALIEFARNVAGMTDAHSTEFNKETPFPVVGLITEWVDEEGNVEQRHEASDLGGTMRLGAQLCHLLEGSKAAQAYKGNSCIERHRHRYEVNNKYRERLEQAGMVFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQKRDLK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: DDB1_CAEEL
Sequence: MPISYCVSAKKASVVVESVVGNFTGHENVNLIVARGNRIDVQLVSPEGLKNVCEIPIYGQVLTIALVKCKRDKRHSLIVVTEKWHMAILAYRDGKVVTRAAGCIADPTGRATDNLFSLTIHRNGLIAIRAFEGSVKMIQWESGTDLRHFNVRFDYPNVSDFKFVDTGEDDVYRVAFIYDDDHGKHLQFSDLNMHDKEFRTYSRQASIAADSSVLIPVPHAIGGVIVLGSNSVLYKPNDNLGEVVPYTCSLLENTTFTCHGIVDASGERFLLSDTDGRLLMLLLNVTESQSGYTVKEMRIDYLGETSIADSINYIDNGVVFVGSRLGDSQLIRLMTEPNGGSYSVILETYSNIGPIRDMVMVESDGQPQLVTCTGADKDGSLRVIRNGIGIDELASVDLAGVVGIFPIRLDSNADNYVIVSLSDETHVLQITGEELEDVKLLEINTDLPTIFASTLFGPNDSGIILQATEKQIRLMSSSGLSKFWEPTNGEIISKVSVNAANGQIVLAARDTVYLLTCIVDEMGALDIQLTAEKKFENEIACLDLSNEGDDPNNKATFLVLAFWSTFAMEVIQLPDLITVCHTDLPTKIIPRSIIATCIEEVHYLLVAFGDGALVYYVFDIKTGTHGEPKKSNVGTRPPSLHRVRNKNRQHLFVCSDRPVIIFSASKKLVFSNVNVKLVDTVCSLSSSAYRDCLVISDGNSMVFGTVDDIQKIHVRSIPMGESVLRIAYQKSTSTYGVCSNRTESKAERVFASKNALVTSQSRPKVASTRADMDESPPNTTSSFMVLDQNTFQVLHSHEFGPWETALSCISGQFTNDSSTYYVVGTGLIYPDETETKIGRIVVFEVDDVERSKLRRVHELVVRGSPLAIRILNGKLVAAINSSIRLFEWTTDKELRLECSSFNHVIALDLKVMNEEVAVADVMRSVSLLSYRMLEGNFEEVAKDWNSQWMVTCEFITAESILGGEAHLNLFTVEVDKTRPITDDGRYVLEPTGYWYLGELPKVMTRSTLVIQPEDSIIQYSQPIMFGTNQGTIGMIVQIDDKWKKFLIAIEKAIADSVKNCMHIEHSSYRTFVFQKRAEPPSGFVDGDLVESILDMDRSVAMDILSKVSDKGWDPSLPRDPVEILKVIEDLARMH
What is the function of this protein?
Plays a role in DNA repair.  May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation.  Histone ubiquitination may be important for subsequent DNA repair (By similarity).  Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division.
What are the official names of this protein?
DNA damage-binding protein 1, Damage-specific DNA-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PMEB_DICD3
Sequence: MSLTHYSGLAAAVSMSLILTACGGQTPNSARFQPVFPGTVSRPVLSAQEAGRFTPQHYFAHGGEYAKPVADGWTPTPIDTSRVTAAYVVGPRAGVAGATHTSIQQAVNAALRQHPGQTRVYIKLLPGTYTGTVYVPEGAPPLTLFGAGDRPEQVVVSLALDSMMSPADYRARVNPHGQYQPADPAWYMYNACATKAGATINTTCSAVMWSQSNDFQLKNLTVVNALLDTVDSGTHQAVALRTDGDRVQLENVRLLSRQDTFFVNTSDRQNSYVTDHYSRAYIKDSYIEGDVDYVFGRATAVFDRVRFHTVSSRGSKEAYVFAPDSIPSVKYGFLVINSQLTGDNGYRGAQKAKLGRAWDQGAKQTGYLPGKTANGQLVIRDSTIDSSYDLANPWGAAATTDRPFKGNISPQRDLDDIHFNRLWEYNTQVLLHE
What is the function of this protein?
Probably involved in the degradation of methylated oligogalacturonides present in the periplasm.  More active on methylated oligogalacturides than on pectin.
What are the official names of this protein?
Pectinesterase B, PE B, Pectin methylesterase B.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Probably active in the periplasm.
Protein: XIRP1_HUMAN
Sequence: MADTQTQVAPTPTMRMATAEDLPLPPPPALEDLPLPPPKESFSKFHQQRQASELRRLYRHIHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGEHERPAAKEPVLCGDVQATSRKFEEGSFANSTDQEPTRPQPGGGDVRAARWLFETKPLDELTGQAKELEATVREPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVRVIRGISLEEGARPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLFETRALDTLKGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQDGEGHLSSDSSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQGEVLAHGSPSREEGTDSAGQAQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMFETQPLDQLGRSPSTIDVVRGITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGKSQGDPQPEAPPKGDVQTIRWLFETCPMSELAEKQGSEVTDPTAKAEAQSCTWMFKPQPVDRPVGSREQHLQVSQVPAGERQTDRHVFETEPLQASGRPCGRRPVRYCSRVEIPSGQVSRQKEVFQALEAGKKEEQEPRVIAGSIPAGSVHKFTWLFENCPMGSLAAESIQGGNLLEEQPMSPSGNRMQESQETAAEGTLRTLHATPGILHHGGILMEARGPGELCLAKYVLSGTGQGHPYIRKEELVSGELPRIICQVLRRPDVDQQGLLVQEDPTGQLQLKPLRLPTPGSSGNIEDMDPELQQLLACGLGTSVARTGLVMQETEQGLVALTAYSLQPRLTSKASERSSVQLLASCIDKGDLSGLHSLRWEPPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQKGMAVLGKSEGATTTPPGPGAPDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAGATQSNIRPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQREPQSRHRETALSVQAPRPLQGGPGQSTGPGREEPGGCTQMAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAGASPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTKTPKLDPTMPPKKKPQLPPKPAHLTQSHPPQRLPKPLPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQGHIPLARCPSGHSQPSLQHGLSTTAPRPTKNQATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGEQPMEGSHQGAPESPDSLQRNQKELQGLLNQVQALEKEAASSVDVQALRRLFEAVPQLGGAAPQAPAAHQKPEASVEQAFGELTRVSTEVAQLKEQTLARLLDIEEAVHKALSSMSSLQPEASARGHFQGPPKDHSAHKISVTVSSSARPSGSGQEVGGQTAVKNQAKVECHTEAQSQVKIRNHTEARGHTASTAPSTRRQETSREYLCPPRVLPSSRDSPSSPTFISIQSATRKPLETPSFKGNPDVSVKSTQLAQDIGQALLHQKGVQDKTGKKDITQCSVQPEPAPPSASPLPRGWQKSVLELQTGPGSSQHYGAMRTVTEQYEEVDQFGNTVLMSSTTVTEQAEPPRNPGSHLGLHASPLLRQFLHSPAGFSSDLTEAETVQVSCSYSQPAAQ
What is the function of this protein?
Protects actin filaments from depolymerization.
What are the official names of this protein?
Xin actin-binding repeat-containing protein 1, Cardiomyopathy-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the Xin family.
What are the subcellular locations of this protein?
Cell junction. Note=Colocalizes with actin stress fibers.
Protein: METN_VIBVY
Sequence: MIEINQVNKVFYQGSKEIHALKDINLHIAEGTIFGVIGSSGAGKSTLIRCVNMLEAPTSGSIVVDGVDLTKLSKKQLSETRRNIGMIFQHFNLLSSRTVFDNVALPLELAGKDKEQIQSKVTELLKLVGLADKHESYPANLSGGQKQRVAIARALASDPKVLLCDEATSALDPATTQSILELLKEINRKLKITILLITHEMDVVKSICHEVAIIGGGELVEKGTVGEIFAHPKTELAHDFIRSTLDLSIPEDYQARLQPTRVAGSYPLVRLEFTGATVDAPLVSQISRKYNIDISILSSDLDYAGGVKFGMMVAELFGNEEDDNAAIEYLREHNVKVEVLGYVL
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BPT_BORBR
Sequence: MPDMSQLKELPFSTLQFYATAPYPCSYLPGRQARSQVAAPGHLINAGTYSQLVEQGFRRSGLFTYRPHCDNCHACVPVRVDAARFEPNRTQRRAWRSHQALRAFVAELAWSPEHYDLYTRYQQGRHPGGGMDEDSRTQYAQFLLTTRVNTRLVEFRAPQGQLAMISIIDVLDDGLSSVYTFYDPDMAGSLGTYSILWQIEQCRTLDLPWLYLGYWIADSRKMAYKANFRPLQMHVDGAWRETPP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST1A1_MOUSE
Sequence: MEPLRKPLVPVKGIPLIKYFAETMEQLQNFTAWPDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPVYARIPFLEFSCPGVPPGLETLKETPAPRIIKTHLPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLYLFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVMDHTIYPFMRKGTIGDWKNTFTVAQSEHFDAHYAKLMTGCDFTFRCQI
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe.  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Displays broad substrate specificity for small phenolic compounds.  Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity).  Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity).  Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase, Phenol sulfotransferase, Phenol/aryl sulfotransferase, mSTp1, ST1A4, Sulfokinase.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_BACC2
Sequence: MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTKPLLDFYDELGYLKSINGEQDINKVFADIDVLIGGLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JAL2_ARATH
Sequence: MEGKIKIGPVGTDYSGKKTMVDWDEGSHNGIISQIFLSHGPTGVFSIQFQFMLDDTFFLSSCHGQNTGSMFDVILLNCPHEYITGISGEYLKSDGASGPQIRSLAFATNLNQYGPFGGSSSQSSIWNHEQQFRFKLGKFRQFSGFYGTYNASGLQNIGVYLQPTIVKPTGTRNAEETESNIVLG
What are the official names of this protein?
Jacalin-related lectin 2.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.
Protein: UBXN1_MOUSE
Sequence: MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLSHVLGREPTPSEQVGPEGSGSAAGESRPILTEEERQEQTKRMLELVAQKQREREEREEREALEREKQRRRQGQELSVARQKLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSRSSPPATDPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS
What is the function of this protein?
Ubiquitin-binding protein that plays a role in the modulation of innate immune response.  Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways.  Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS.  In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome.  This function probably serves as a brake to prevent excessive RLR signaling.  Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1.  Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B.  Interacts with the BRCA1-BARD1 heterodimer and regulates its activity.  Specifically binds 'Lys-6'-linked polyubiquitin chains.  Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer.  Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
What are the official names of this protein?
UBX domain-containing protein 1, Protein 2B28, SAPK substrate protein 1, UBA/UBX 33.3 kDa protein, mY33K.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATL3_FASHE
Sequence: DVPASIDWREYGYVTEVKD
What is the function of this protein?
Thiol protease.
What are the official names of this protein?
Putative cathepsin L3, Newly excysted juvenile protein 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: PTLCB_STAHJ
Sequence: MNKLIAWIEKGKPFFEKISRNIYLRAIRDGFIAAIPIILFSSIFILITYVPNVFGFTWSKTMEGILMKPYNYTMGIVGLIVAGTTAKSLTDSYNRKLDKTNQINFISTMMAAMSGFLFLAADPIKEGGFLSAFMGTKGLLTAFISAFITVIVYNFFIKRNITIKMPKEVPPNISQVFKDIFPLSAVIIIIYALDLLSRTFIHTNVANAVLKIFEPLFTAADGWIGVTLIFGAFAFFWFVGIHGPSIVEPAIAAITYANLETNLNLIQAGEHADKIITPGTQMFVATMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPVFFIPFIFAPIVNVWIFKFFVDVLKMNSFSIFLPWTTPGPLGIVMGTGFAFWSFVLAIVLIVVDVMIYYPFLKVYDEQILEEERGNKEVNNELKEKVSANFDTKKADAILATAGANETTTTESAPSDEEVSAKNSSNSINEQTNVLVLCAGGGTSGLLANALNKAAEEYQVPVKAAAGGYGAHMDIMKDYQLIILAPQVASNYEDIKQDTDRLGIKLAKTQGVEYINLTRDGKAALDFVQQQFEK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II LacEF PTS system is involved in lactose transport.
What are the official names of this protein?
PTS system lactose-specific EIICB component, EIICB-Lac, EII-Lac.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TPIS_STAEQ
Sequence: MRTPIIAGNWKMNKTVQEAKDFVNELPTLPDPKEVESVICAPTIQLDALVTAVKDGKAKGLKIGAQNAYFEESGAYTGETSPVALSELGVKYVVIGHSERRDYFHETDEEVNKKAHAIFNHGMTPIICVGESDEEREAGKANKIVGNQVKKAVEGLSDDQLKEVVIAYEPIWAIGTGKSSTSEDANEMCAHVRQTLADLSSQEVADATRIQYGGSVKPNNIKEYMAQSDIDGALVGGASLKVEDFVQLLEGAK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.