PharMolix/UniProtQA huggingface dataset:
Protein: HPRS_ECOLI
Sequence: MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDSINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDIASPGTKINEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLPQRN
What is the function of this protein?
Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide (PubMed:25568260, PubMed:27983483).  Senses H(2)O(2), maybe via the redox state of the membrane (PubMed:27983483).  Activates HprR by phosphorylation (PubMed:15522865).  Can also phosphorylate CusR (PubMed:15522865).
What are the official names of this protein?
Sensor histidine kinase HprS, Hydrogen peroxide response sensor.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_UROPO
Sequence: MATNIRKTHPLFKIINNSLIDLPTPTNISIWWNFGSLLGLCLIIQILTGLFLAMHYTADISSAFSSVAHICRDVNYGWLIRNIHANGASLFFICIYLHIARGLYYGSYIYKETWNIGVIILLLLMATAFVGYVLPWGQMSFWGATVITNLLSALPYIGDMLVQWIWGGFSIDNATLTRFFTFHFLLPFIIAALTMVHLLFLHETGSNNPTGLDSNMDKIPFHPYYSYKDLLGFFILLLLLTLLALFMPYSLGDVENFIPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILLLVPMLHTSKQRNLTFRPITQLLFWLLVTNTIILTWVGGQPVEQPFITIGQIASITYFSFFLILFPLAGWWENKMLNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: URE1_METPP
Sequence: MATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMGQSQRPNGPGPHDAVDCVVTNALILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVIGPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVTTMLGGGTGPATGTFATTCTPGPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCCLSVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEANFLPSSTNPTMPYTVNTLDEHVDMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLGAISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDPERHDNGRAKRYVAKYTINPAIAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVHYRPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLPRMEVDAQTYQVRADGQLLTCEPATALPMTQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPAM1_PONAB
Sequence: MARDLIGPALPPGFKARGTAEDEERDPSPGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDTGPTARKQRKNQDDDNDDDDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPAEMKDFGLGPRTFKRRADDTSGDRSVWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL
What are the official names of this protein?
GPALPP motifs-containing protein 1.
Protein: TAG2O_AGEOR
Sequence: MKAIISLLLISAMVFSMFEAVPVRRRFTAFEGERGCLPHNRFCNALSGPRCCTGLKCKELSIWDSRCLG
What is the function of this protein?
Insect active toxin causing rapid but reversible paralysis in crickets.  No activity shown in mammals.  Does not show effect on mammalian voltage-gated calcium channels (By similarity).
What are the official names of this protein?
U2-agatoxin-Ao1o, U2-AGTX-Ao1o, Toxin-like structure Agel_14.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2090_VIBC1
Sequence: MIYSTTETIPGREIAEIKGVVTGNVVQSKHIGRDLMAGLKSIVGGEIRGYTEMMTEARNIAIQRMVEDAANLGADAVVGIRFTTSSIVDGSSEILAFGTAVKLL
What are the official names of this protein?
UPF0145 protein VIBHAR_02090.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RSMF_PSYIN
Sequence: MHSKTRLPQAFIDKMTGILPNQLKIEDFIAVCQRPLRRAIRVNTLKISVEKFQIRAQEQGWVLTAIPWCAEGFWIELQEEPTPLGNSAEHLGGLCYIQEASSMLPVAALFHFFTPTTQSIVLDAAAAPGSKTTQIAAKMNNSGLIIGNEFSSSRIKMLHANIQRCGIKNVALTHFDARVFGKWLPGTFDAILLDAPCSGEGTVRKDKYAMNNWSQSSINEIASTQQELILSAFHALKEDGILIYSTCTLSHEENQDICFFLKDKFPEHIEFLDLETLFTDAKKTRTAEGFLHIWPQVYDSEGFFVAAIKKTKACTVAPAVKRLGKFPFIRPTRQKEQALYEYFASQFAITNIKGMLYQRDQELWLFPDPIKPLIKELRFSRLGIKIAEEFGNGRKSGFKSTHEFVTCFGDSIDAHKLELSAEQAQEFYQGRDIRDIDAKGFKGEVLLSYRGHVIGLGKSLDNRIKNSLPRELIRDNNLFIK
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPB_ALKCK
Sequence: MTQAKDVALIFELSKQGRVGHSLPNLDIEEQPLESLLPEAYVREEEPELPEVSELQIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEDIARLPGLVHVHPYQPEEQVQGSLKMLYSLQTALAEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEANGDKKRTKVVVPDSAHGTNPASATVAGFESVTVRTNEAGLVDLDHLREVVNEETAALMLTNPNTLGLFEADIQEMADIIHRAGGKLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELVPFLPKPVLVNDDGFFRFDSDRPQSIGRVKPYYGNYGINLRAYTYIRTMGPDGLRQVSENAVLNANYMMRRLESYYDLPYAQHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNVEECMMIEPTETESKETLDEFIEAMIQIAKEAEESPELVQEAPHHTVIKRLDETLAARKPILRYEMKKETV
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: COWN_TRIL1
Sequence: MSKPDRYVSFVGIDGDSNARKLVALLRRHIDDPARTNRFWELFKDKLEKINKPDETSGFSQDELYLVHAYINNIRELFETYDDQPALALLDRIEAESC
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.
Protein: MCM7_XENTR
Sequence: MPRDYQAEKEKCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRDPSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELGTEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQPLDMKLMRRYITMCKRKQPAIPESLADYLTAAYVEMRKEARTNKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
What are the official names of this protein?
DNA replication licensing factor mcm7, CDC47 homolog, Minichromosome maintenance protein 7.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: CARA_THEVB
Sequence: MPTPALLVLADGSVFRGFSFGAPGTAIGEVVFNTGMTGYQEVLTDPSYYGQIVTFTYPELGNTGTTPEDDESDRPQVRGAVARNICDIPSNWRSQQSLPDYLKAHRIPAIYGIDTRALTRKIRTVGAMNGGISTEILDPVELLQKVLAAPSMQGQNLAKVVTTRTPYEWTEPTPAAWEFRPQTATEEPPLTVVAIDFGVKRNILRRLASYGCRVIVVPADTPAETILSYDPDGIFLSNGPGDPAAVQEGIETTRKLLGAQRPMFGICLGHQLLGLSLGAETFKLKFGHRGLNQPAGLTQEVEITSQNHGFAITAESLAQTPVEITHFNLNDKTVAGLKHQTLPIFSVQYHPEASPGPHDADYLFGEFVAQMRAYRQQHPRRQ
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: GERLA_BACCE
Sequence: MGKLLELEGNLFEVMKEIRDELGSPNDLTIREVALAGSFTRCAVVFLCGLTDKDNVYKYVVRTLQYEEVQNEAAVVQTLLDRFISIAEVGKKTTFPDIINAILAGDTVILIDNIQTAIIINSRAWEKRSLEPPVTEDLIRGPRVGLNEDINVNKMLIRRSLRDPKLRFQSYIMGKRSQKEVTLVYIEDIINPHIVKELDRRLQSIVTDVVLETGTIEQLIQDNNLSPFPQFLNTERPDNIIASLAKGKAAILVDGSPFALIAPLVFVDIFQSVEDHYERWVIGTLLRFLRMGSGIIAVLLPAMYVALVSYHQGLIPSKLAYSIAGAREGVPFPAYIETLMMALTMELIREAGIRLPKPMGQTIGIVGGLVIGEAAVNAGIVNPFLVIIIAVTAIATFSLPVYSITITFRILLFVFVLAATAFGLYGIILALIALAIHITNLTSVGIPYTTPIAPAFYKDWKEEFIRMPKSMLKDRPEYLQTKDSTIRPKERK
What is the function of this protein?
Contributes to the L-alanine germination response.
What are the official names of this protein?
Spore germination protein GerLA.
What is the protein family that this protein belongs to?
Belongs to the GerABKA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: METL5_DROME
Sequence: MARLKLRKLEEYLQGVDGFEQPKILLEQYPTPPHIAACMAHHMQSQHEDIEGKLVGDLGCGCGMLSIASTLLGAQLTVGFELDGDAVDTFRGNVVEMELPNVDCVRADVLQLIGSKWEKSFDTVLMNPPFGTKHNAGMDMRFLEVALRLANRAVYSLHKTSTRSYIQKKALEWGARGSVVAELRYNIDASYKFHKQKSKDIEVDFWRFEIGTE
What is the function of this protein?
Catalytic subunit of a heterodimer with Trmt112, which specifically methylates the 6th position of adenine in 18S rRNA.
What are the official names of this protein?
rRNA N6-adenosine-methyltransferase Mettl5, Methyltransferase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPH_LACH4
Sequence: MTKLDAKSIINYIGNAPKKTPVKVFIKGQLDQIDFPEEIENFNETHSGVIFGDWKDVEPFLKENQDKIQDYRIENNARNSAVPMIDMKKFDARIEPGAIIRDQVAIGKNAVIMMGAIINIGAEIGDDTMIDMGVVLGGRAIVGKHCHIGAGSVLAGVIEPASATPVKIDDNVVMGANAVVIEGVHVGEGAVIAAGAVVTHDVEPHTMVAGVPAKVIKKVDDQTESKTGLEDNLRKI
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: RL33_FRATM
Sequence: MREKIRLVSSAKTGHFYTTTKNKKEMPNKMEIKKYDPVVRKHVMYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RL32_BDEBA
Sequence: MPTPKKKTSRSKRDMRRSHDGLTAPAIAVEKKTGELVRPHRAHKGADGALYYKGKQISAAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: DDL_YERPA
Sequence: MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_SERP5
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFFDSDQEIERRTGADVGWVFDVEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQVDSPPREVLEALAKERNPLYEEIADVTIRTDDQSAKVVANQIINMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNCG_RAT
Sequence: MSDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII
What is the function of this protein?
Participates in processes of transmission and amplification of the visual signal.  cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (By similarity).
What are the official names of this protein?
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma.
What is the protein family that this protein belongs to?
Belongs to the rod/cone cGMP-PDE gamma subunit family.
Protein: HIS1_SERP5
Sequence: MLDKTRLRIAMQKSGRLSDESQELLARCGIKINLQQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLTRRAQGEDPRYFTLRRLDFGGCRLSLATSLDSEYTGPQSLQDARIATSYPHLLKQYLDKQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMPEAKQQLIDRLMTRIQGVIQARESKYIMLHAPSERLDEIVALLPGAERPTILPLAGAQNRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_ECO45
Sequence: MRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYENATRDIAVLEDAGVPYQLLESSRLAEVEPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPVDQLLCDGEQIYGVKCGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGRTRFKNLWLNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPLRPGHLHGAHS
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: GLYA_HYDTT
Sequence: MRHLFNTDAEIYEAIVKEYERQFYHLELIASENFTSLAVMEAQGSVMTNKYAEGLPHKRYYGGCEFVDIAEDLAIERAKALFDAEHANVQPHSGTQANMAVYMAVLKPGDTIMGMDLSHGGHLTHGAKVNFSGKIYNAVYYGVHPETHLIDYDQLYRLAKEHKPKLIVGGASAYPRVIDWAKLREIADSVGAYLMVDMAHYAGLIAGGVYPNPVPYAHFVTSTTHKTLRGPRSGFILCKKEFAKDIDKSVFPGIQGGPLMHVIAAKAVAFKEAMSQEFKEYARQVVANARVLAEEFIKEGFKVVSGGTDSHIVLLDLRDTGLTGREVEEALGKANITVNKNAVPFDPLPPVKTSGIRLGTPAMTTRGMKEDQMRIIARLISKVIKNIGDEKVIEYVRQEVIEMCEQFPLYPELREEINHLAKIKATY
What is the function of this protein?
Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  Thus, is able to catalyze the cleavage of L-threonine, L-allo-threonine, L-threo-beta-phenylserine and L-erythro-beta-phenylserine.  This second activity is likely to be physiological in H. thermophilus, which is an organism that lacks the ortholog gene for the 'real' threonine aldolase characterized in mesophilic bacteria (LtaE), yeast and plants.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase, L-threonine/L-allo-threonine aldolase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_SULTO
Sequence: MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLVKTLKIGGATVALAGSNPLSTQDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQIIMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEEQGVLRYPVIAVNNAFTKYLFDNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRALEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVKGLKEMAKSSRLIRPNLEEYELPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSVKYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPMTQEQIEYMKQWRYGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATRX_SENDE
Sequence: MADIYRFPKFSYEDNGTVEPLPLRTGPDKKAIPHIRIIKVGVPPKHGVRYLDLLLLGFFETPKQTTNLGSVSDLTEPTSYSICGSGSLPIGVAKYYGTDQELLKACTDLRITVRRTVRAGEMIVYMVGSIGAPLLPWSGRLRQGMIFNANKVALAPQCLPVDKDIRLRVVFVNGTSLGAITIAKIPKTLADLALPNSISVNLLVTLKTGISTEQKGVLPVLDDQGEKKLNFMVHLGLIRRKVGKIYSVEYCKSKIERMRLIFSLGLTGGISFHVQVTGTLSKTFMSQLAWKRAVCFPLMDVNPHMNMVIWAASVEITGVDAVFQPAIPRDFRYYPNVVAKNIGRIRKL
What is the function of this protein?
Plays a crucial role in virion assembly and budding.  Forms a shell at the inner face of the plasma membrane and concentrates the HN and F glycoproteins.  Acts as a negative regulator for transcription and replication by sticking to the nucleocapsid.  This effect might be regulated by the cytoplasmic interaction with tubulin that dissociates the M protein from the nucleocapsid (By similarity).
What are the official names of this protein?
Matrix protein, M protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells.
Protein: CYB_PELUR
Sequence: MAPNLRKSHPLLKMINNSLIDLPTPSNISAWWNFGSLLGICLLTQILTGLLLAMHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMITGLTTIHLTFLHESGSNNPLGITSNCDKIPFHPYFTLKDFLGFTLMLLPLTTLALFSPNLLGDPENFTPANPLITPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLAPFLHKAKQRTMTFRPISQLLFWILVTNLLILTWVGSQPVEHPFIIIGQLASITYFTILLILFPIIGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MGMT_LODEL
Sequence: MLVKTLYYRLVEGTFAKAMLVLDEKGTLYYASLGEDSNALRETLVTDFASKQRQFQLKPMVTLSNHERADYTALCFLKLMEEEEDWKNEGEESLQQKGAKRIPIEFIFGTELQRKVWQQLLEIPVGEVRYYGNIVEALGLPKSASRAVGNACGANKIALVVPCHRVIAQTGKLTGYRWGLATKKQILKMELGDAYTTLVSE
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, DNA repair MTase, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRAM_I35A3
Sequence: MNPNQKIITIGSICMVVGIISLILQIGNIISIWISHSIQTGSQNHTGICNQSIITYKNSTWVNQTYVNISNTNVVAGQDTTSVILTGNSSLCPIRGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNEAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKIFKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPKDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSTSSRHGFEMIWDPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGQPKEKTIWTSGSSISFCGVNSDTVDWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.