PharMolix/UniProtQA huggingface dataset:
Protein: YL404_MIMIV
Sequence: MGLFHSIFSLPSTINDSIEKQIYMPPYIPRFYYESLNTNYSKIFTRTSSNGDDIPIVQIRPKNNPFPQKYIVFSHGNGCDVYSVFSYLTNLSDKLDVGIITYDYVGYGLSRDNIPTEQGCYDSIEVAVDFLLNDYGLDPKNIYLFGQSLGTGITIDYAHKNNWNSPIILVSPYKSICTVVVDSCIVRPIDKFCTLNKIYQIKCPVKIFHGENDNVINITHGKKIYDSLNDKSLEPVWIPNTGHNDILDKITIQQIREVIDYFD
What are the official names of this protein?
Putative alpha/beta hydrolase L404.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: HEMH_RICFE
Sequence: MKKRIAIVLFNLGGPKNLESVKPFLFNLFYDKAIINLPNPFRYIIAKIISTTRERKSQKIYSLIGGKSSLLQETEEQKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIDQIKKYNPSEIILLPLYPQFSSTTTGSSVKNFLQNFDIDISIKTICCYPQEEDFIKSHVSLIKEKLYDDDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGPIEWLKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEVQYTRIPTLGTNKIFINSLTNILLQFINKVDTNLVTSSSSTRICPNEFTKCLCKLTN
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAV_DROER
Sequence: MSDTQISSFLRKYLADEDRKIRAQFKESDPKNKLILWMHEKTRITEDDLKRPYTKDEVRELCLRTKVKVDMTAWNCLWEAKKRFDAKGRFENKSEKFINRMYMKAVRRKMVQPYPEEYVAQRREVIAAETKKFNISRLDRWQKQKSQNRSAPESSSALVGHASQQDSQDNEAVETHEDQANTNRYSVSQMEPMARPVVSASDLSGIGDDEDEQQQQQSEFQTEHTDCPETQMRCDQINSGSLPMGLTNSESAPDYYMFGTQLSTSVRPTSTQEADDQIACPETETNESWVRCDQINSESMSIGPSIDSEGNISLQNSGSEPIDVDSMA
What is the function of this protein?
Binds to chromosome ends in a sequence-dependent manner and is required for telomere capping.
What are the official names of this protein?
Telomere-binding protein cav, Protein caravaggio.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: CLPX_ECOBW
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: DDLB_CLOTE
Sequence: MLLAQQLNLYILKGEIIMKKIKIAIVFGGQSTEHEVSRNSVTSILKNINRDKYEICPIGITKEGKWFQYTGDINNIKNGQWEKDNKNKLENGYNVLFNKEVELVFPVLHGLYGEDGTIQGLCKLVGLPCVGPGVLSSALCMDKIYTKYVLENFKFKQANYVVVNKFEYEKNKEEIIKEVEKLQYDVFIKPANSGSSVGITKAHNKEELLKGLEEAFIHDKNVLVEEAINAREIEVAVLGNDDPKAAVPGEIIPAKEFYDYEAKYQNENSELLIPANIDNIKQEEIKELAIKIYKLLGCSGLARVDFLMDKESNEVYFNEVNTLPGFTKISMYPKLWEASGKSYSALIDELIELAINNK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase B, D-Ala-D-Ala ligase B, D-alanylalanine synthetase B.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_VIBCH
Sequence: MSVWNAVHLSRRFAALPQAFYTPVHPQPLQNVRWGMWNSRLAQQFGLPEAPNDELLLSLSGQQLPADFSPVAMKYAGHQFGVYNPDLGDGRGLLLAEMATKQGEVFDIHLKGAGLTPYSRMGDGRAVLRSSLREYLCSEAMAGLGIATTRALALMSSETPVYREREERGALLVRLAHTHVRFGHFEHFFYTDQHANLKLLADKVIEWHFPDCVQTSKPYAAWFSQVVERTALMIAQWQAYGFNHGVMNTDNMSILGETFDYGPFAFLDDYDPNFICNHSDYQGRYAFDQQPRIGLWNLSALAHALSPLIDKDDLEAALGSYSERLNLHFSRLMRAKLGLATQQEGDGELFADFFALLANNHTDYTRFLRELSCLDRQGNEAVIDLVLDREAAKTWLTRYLERAARELGQEGRPISTRERCQAMRQVNPKYILRNYLAQQAIEFAERGDFEEMQRLATVLASPYAEHPEFERYAKLPPEWGKKLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: BETB_ACIB5
Sequence: MSDVQVHQLYIHGRYVEATSGKTFNSINPANGEIIATLQQASEQDIEAAVKSAQQGQKIWAAMTAMERSRILRRAVDILRERNDELARLETLDTGKAYSETSTVDIVTGADVLEYYAGLATAIQGEQVPLRESSFFYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSETTPLTALKLAEIYTEAGLPDGVFNVVQGAGREIGQWLTEHPVIEKISFTGGVETGKKVMASAAGSTLKEVTMELGGKSPLIICEDADLNRAADIAVMANFFSSGQVCTNGTRVFVPKSRLADFEKAVVERVKRIRVGDPMAEDTNFGPLTSFPHMEKVLSFIESGKQQGAKVLIGGGRATEGELAKGAYVLPTVFSDCTDQMAIVQEEIFGPVMSILSYETEEEVIQRANDTTFGLAAGVVTQDISRAHRIIHQIEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLGHYTRIKSIQVELGDYQSIF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: REXO3_ASPFU
Sequence: MFAPLGLFKDVPCPEGQQCSLLTCIFSHDPLSPSLVNPSNVQGTLVAPEEAYESGPPPKKPRLETPPKTAGGKAQSLSEPRMESIESAPAPKAVRGSGLEQTTRTASQLQSMTREVSPPTLQKESSAKKHAPPAATEGEAHLPPRRAPRESLNPRMLPKAPAAHGVRLSILTKLHAAMCALNEKLAKEEGSTDNPLVLSPNELVTMALDEEEKAAKDNPSIYANVIKLRIVKLPKLSLEEWKKEVKAHLNERYYKIEPTQRTAEQKTLETGLSPKEEIAIASKLITPLEGLEQYGYVTRKPTKEEVENARRGVSESKGWEKCDRCGGRFQVFPGRREDGSLTTGGQCTYHPGKPYYPPRRQTDHITGARDAYFPCCNESIGTSSGCTKGNTHVFKVSESKRLASILQFEETPTQADKGPQQPVCFDCEMGYTTLGLELIRLTAVSWPQGKLLLDILVRPMGEILDLNSRFSGVFPEHYQKAIPYKSTSSPSTTGDGALQVVESPAAARALLFKFLQPDTPLIGHAIDNDLNACRIIHPTIIDTVLLYPHPRGLPIRMGLKALVKKYLDRDIQTKGSQGHDSKEDAIATGDLVRVKAAETWKILKSKGWRIEGSKLIPPPGAKGASEDSKLGPGAGHKRKDTEVMP
What is the function of this protein?
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
What are the official names of this protein?
RNA exonuclease 3.
What is the protein family that this protein belongs to?
Belongs to the REXO1/REXO3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GPX4_BOVIN
Sequence: MSFSRLYRLLKPALLCGALAAPGLASTMCASRDDWRCARSMHEFSAKDIDGRMVNLDKYRGHVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNAEIKEFAAGYNVKFDLFSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPCYL
What is the function of this protein?
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity).  Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity).  Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity).  Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity).  The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity).  The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity).  May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).  Required for normal sperm development and male fertility (By similarity).  Essential for maturation and survival of photoreceptor cells (By similarity).  Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).  Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity).  Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
What are the official names of this protein?
Phospholipid hydroperoxide glutathione peroxidase, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm.
Protein: SYQ_SALG2
Sequence: MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGQCNLRFDDTNPVKEDIEYVDSIKNDVEWLGFHWSGDIRYSSDYFDQLHAYAVELINKGLAYVDELTPEQIREYRGTLTAPGKNSPFRDRSVEENLALFEKMRTGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYPQGESEMVTMPNHPNKPEMGSREVPFSGEIWIDRADFREEANKQYKRLVMGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPIEIRLYDRLFSVPNPGAAEDFLSVINPESLVIKQGYGEPSLKAAVAGKAFQFEREGYFCLDSRYATADKLVFNRTVGLRDTWAKAGE
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP21_ORYSJ
Sequence: MELDLNNVAEGVVEKHETAARSDSGTSESSVLNGEASGAAIAPAEEGSSSTPPSPPPPPAAVLEFSILRSSASASGENDADDDEEEEATPSPPPHHQHQQLLVTRELFPSAAPSPQHWAELGFLRPDPPRPHPDIRILAHAPPPAPPPPPPQPQPQAAKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFNLSDYEEDMRQMKSLSKEEFVHVLRRQSTGFSRGSSKYRGVTLHKCGRWEARMGQFLGKKYIYLGLFDSEVEAARAYDKAAIKCNGREAVTNFEPSTYDGELPTDAAAQGADVDLNLRISQPAASQQSPKRDSGSLGLQIHHGSFEGSEFKRAKNDAAPSELASRPHRFPLLTEHPPIWTAQPHPLFPNNEDASRSSDQKRKPSEGVAVPSWAWKQVSHHHPAPPHTLPLPFFSSSSSSPSSSSAAASSGFSKAATTAAAAQHTATLRFDPTAPSSSSSSRHHHHH
What is the function of this protein?
Probable transcription factor (By similarity).  Involved in spikelet transition (Probable).  Regulator of starch biosynthesis especially during seed development (e. g.  endosperm starch granules); represses the expression of type I starch synthesis genes (PubMed:20713616).  Prevents lemma and palea elongation as well as grain growth (PubMed:28066457).
What are the official names of this protein?
APETALA2-like protein 1, APETALA2-like protein 23, Protein RICE STARCH REGULATOR 1, Protein TARGET OF EAT 1, OsTOE1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEND_HAEIG
Sequence: MSVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCHTHFDERGLGFFALGIAKATQSPVAIIVTSGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGANQAILQQNMFGQYPVANVNLPKPNADYSAQWLISLLEQAAFQQKQQGGVVHINVPFAEPLYDATDEEVNSHSWLQPLQRWLIQKKSWINVEVQQNEVLMHENWDHWRTKRGVVVVGQLPAEQAMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISKRINQFLQAFKGEFWLVEQSGKALDPYHHSLTRFNAKVHHWLRAHPPLRQKPWLLEPLALSKFCATFIEQQVGGNLTEASLALRLPTLLPYNGVLFLGNSLLVRLVDALTQLPESYPVYTNRGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTLIFVINNNGGAIFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATLIEIKTNPSDGSSLYKRLIEQISHAVIGA
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: PAND_PHOV8
Sequence: MMIEVLKSKLHCVRVTEANLNYMGSITIDEDLMDAANMIAGEKVHIVDNNNGERFETYIIKGERGSGCICLNGAAARKVQVGDIVIIMSYAMMDFEEAKSFKPTVVFPDSAMNKIV
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_BURCJ
Sequence: MSVYGLQRLYIGGGYVDATSGKTFDTFDPATGELLAQVQQASAADVDRAVASAQEGQREWAAMTAMQRSRILRRAVDLLRERNDELAAIETRDTGKPIGETLAVDIVTGADVIEYYAGLATAIEGLQVPLRAESFVYTRREPLGVCAGIGAWNYPIQIACWKTAPALAAGNAMVFKPSEVTPLTALKLAEIYTEAGVPAGVFNVVQGDGSVGALLTGHPDIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSSGQVCTNGTRVFMHRSVKDAFTQKVLERVKRIRVGKPTDADTNFGPLVSAAQLDKVLGFIESGKAEGAKLLAGGTRLTDGHFGSGQYVAPTVFGDCRDDMKIVREEIFGPVMSILDFESEDEVIARANDTHYGLAAGVVTENLSRAHRTIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYNPVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: LOLB_SODGM
Sequence: MHERNYAVFRLLPLASLLLAACSVHTPSGPAKSQTSPEWRAHQQSLSALGRYQTRGAFAYLSSQQKVYALFNWQQTSADRYRLILTNPLGSTEMDLNVQPGVAQLVNNQGKRYVSDDPEVMIQKLAGMSIPLNDLRQWMLGLPGDATDFTLDSRGYLHTLNYSHNGQLWTVTYQGYHDDTVPALPSNLKLRQGDNRIKLKMDSWSL
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PTN20_HUMAN
Sequence: MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD
What is the function of this protein?
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli.  Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 20, hPTPN20.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.
Protein: ILVC_IGNAA
Sequence: MAKIYKDEDISLEPIKNKTIAILGYGSQGRAWALNLRDSGLNVVVGLERQGDSWRRAIDDGFKPMYTKDAVAIADIIVFLVPDMVQKSLWLNSVKDFMKKGADLVFAHGFNIHFKIIEPPKDSDVYMIAPKSPGPIVRRSYEMGGGVPALVAVYQNVSGEALQKALAIAKGIGCARAGVIESTFKEETETDLFGEQVILVGGIMELIKASFETLVEEGYQPEVAYFETVNELKLIVDLIYEKGLTGMLRAVSDTAKYGGITVGKFIIDKSVRDKMKIVLERIRSGEFAREWIKEYERGMPTVFKELSELEGSTIETVGRKLREMMFRGMKQISSH
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NAD(P)(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: IPRI_DANRE
Sequence: MQGAIARVCMVVVAAILNHPLLFPNENTTVPEQDEDLLARMKEHQEKLEAEQKRLEQEISQNETSVIGDQDGYGWYFWSALCLVIFFTIEVCRQDLISAEIPDPAEDEDGDCSTGYHSAKSIALDRGTLNNFCKTRFFPYTNESGRVREFIEGFADDLLEALRSICDLKADLEVEDFAGIGSMFESWRVSKPPTCDLIVPFSPPQPLRFQFELWCDPSTEIPLDLQGCGRIQLIKPGGNGTDCLCGSIDLGDDMLCLLHNRNECEVLEDDALPELLCARDTTYLSKGQIMRWFQISVSKAWGKISHKYDFELAFRNLDFPGALKIKFPSGKTVVLNLTPAVQFENTDAYLISHFPSDTSNSSDTHWQLSLSVYEKNLLKHLAKSLPTNSCHIHCLQIVAFLHKKQTTLTGRSAFCNYHIKTALLHLLLSKRPAMWQPQNLDSRLRDLLSFLQQSLEEKKLYHALVGNPRIPVEILVPKIIRTAEPINLYRPLVLQRHVYAKMEEHFEEMVRNTSVLVQEYTPHFSNGHVRHEFSSAEQI
What is the function of this protein?
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
What are the official names of this protein?
Inositol 1,4,5-trisphosphate receptor-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the ITPRIP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus outer membrane; Single-pass type I membrane protein.
Protein: RL18_STRGC
Sequence: MITKPDKNKVRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQVIDDVAGVTLASASTLDKEVSKGTKTEQAVVVGKLVAERAVAKGISEVVFDRGGYLYHGRVKALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: MOAC_BACAH
Sequence: MSSFTHFNDQGRAKMVDISDKKATVRTAIACSSIVVTKEIYDKISHNEIGKGDVLAVAQIAGIMAAKRTSDIIPMCHPLLLKGVDVSFDWKQSDEQYRLLIEVKVKTEGSTGVEMEALTAASATALTVYDMCKAVDKGMIIGETYLLEKTGGKSGDYTRKS
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RS13_HELMI
Sequence: MARIAGIDLPRDKRIAIALTYIFGIGRPTADKILAETGINPDTRTRDLTDEEVARLREYIDKNVEVEGDLRREISLNIKRLMEIGCYRGLRHRRGLPVRGQRTKTNARTRKGPARTVAGKKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ASTE_SHIB3
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: STN1_MACFA
Sequence: MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVVGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIERRTKIEIGDTIRVRGSIRTYREEREIHATAYYKVDDPVWNIQIARMLELPTIYRKIYDQPFRSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLCLANQPVIHSACSDQVNFKKDTTSKAIHSIFKNAIQLLREKGLVFQKDDGFDNLYYVTREDKDLHRKIHQIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
What is the function of this protein?
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  Initially the CST complex has been proposed to protect telomeres from DNA degradation.  However, the CST complex has been shown to be involved in several aspects of telomere replication.  The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity.  The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha.  The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins.  Required for efficicient replication of the duplex region of the telomere.  Promotes efficient replication of lagging-strand telomeres.  Promotes general replication start following replication-fork stalling implicating new origin firing.  May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
What are the official names of this protein?
CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog.
What is the protein family that this protein belongs to?
Belongs to the STN1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: AROQ_CAMJR
Sequence: MKIMIIQGPNVNMLGVREVGIYGAMKMEEIHEQMKLAASQNNVELDFFQSNFEGEIVDKIQECLGTVDGIIINAAGYTHTSVAIRDAIAAVALPTIEVHISNVYRREEFRQKSLIAPVCSGTIVGFGPFGYHLALMGIIQICEQIKNLRAMQQAQQTNK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: CLPX_STRR6
Sequence: MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVENILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVDGTDKPILETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.