PharMolix/UniProtQA huggingface dataset:
Protein: MARH5_MOUSE
Sequence: MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
What is the function of this protein?
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission.  May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.  Promotes ubiquitination of FIS1, DNM1L and MFN1.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF5, Membrane-associated RING finger protein 5, Membrane-associated RING-CH protein V, MARCH-V, RING-type E3 ubiquitin transferase MARCHF5.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: OAT_CAEEL
Sequence: MLSSLRRVVPSLPRGSRSLTSQQIFDREKKFGCHNYKPLPVALSKGEGCFVWDVEGKKYFDFLAAYSAVNQGHCHPKLLKVVQEQASTLTLTSRAFYNNVLGEYEEYVTKLFKYDKVLPMNTGVEACESAVKLARRWAYDVKGVKDNEAVVVFAENNFWGRSIAAISASTDPDSFARFGPFVPGFKTVPYNNLKAVEDAIKDKNVAAFMVEPIQGEAGVVLPDPGYLKGVSDLCKKYNVLFITDEVQSGLGRSGKLLAHYHDNVRPDIVVLGKALSGGFYPVSAVLCDDNVMMNIKPGEHGSTYGGNPLACKVAIAALEILQEEKLVENSAVMGDLLMSKLKTLPKDIVSTVRGKGLFCAIVINKKYDAWKVCLKLKENGLLAKNTHGDIIRFAPPLCINKEQVEQAADIIIKTVTDFAKQN
What are the official names of this protein?
Probable ornithine aminotransferase, mitochondrial, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VACHT_HUMAN
Sequence: MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
What is the function of this protein?
Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles.  Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (PubMed:8910293, PubMed:20225888) (By similarity).  Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity).  Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity).  Can transport serotonin.
What are the official names of this protein?
Vesicular acetylcholine transporter, VAChT, Solute carrier family 18 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Vesicular transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRAP_CLVN
Sequence: MQSSSPSPNHSTQVPIKVSHRQFKKRAIRRRRVDLVCGCSYYLHINCSNHGFTHRGTHHCSSSNEWRVYLGNKQSPVFHNHQAPTTTIPAEPGHHNSPGSIQSQPEEGAGDSQMFSQLQDLDDLTASDWSFLKSL
What is the function of this protein?
Strong activator of the late viral genes promoters.  Enhances the expression of the capsid protein and nuclear shuttle protein.  Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway.  Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense.  Determines pathogenicity (By similarity).
What are the official names of this protein?
Transcriptional activator protein, TrAP, 15.2 kDa protein, Protein AC2, Protein AL2.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae transcriptional activator protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=The phosphorylated form appears to accumulate almost exclusively in the nucleus, whereas the non-phosphorylated form is found in both nucleus and cytoplasm.
Protein: JZ13A_CHIGU
Sequence: MKTSVLFVIFGLALLFCLSFAAELEDTGRQCGEFMWKCGAGKPTCCSGYDCSPTWKWCVLKSPGRR
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U10-theraphotoxin-Cg1a 1, U10-TRTX-Cg1a, Jingzhaotoxin-13, JZTX-13, Peptide F5-18.88.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 29 (Jztx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AC132_NPVAC
Sequence: MSDKTPTKKGGSHAMTLRERGVTKPPKKSEKLQQYKKAIAAEQTLRTTADVSSLQNPGESAVFQELERLENAVVVLENEQKRLYPILDTPLDNFIVAFVNPTYPMAYFVNTDYKLKLECARIRSDLLYKNKNEVAINRPKISSFKLQLNNVILDTIETIEYDLQNKVLTITAPVQDQELRKSIIYFNILNSDSWEVPKYMKKLFDEMQLEPPVILPLGL
What is the function of this protein?
Plays an essential role in nucleocapsid entry in host nucleus.  May act by binding and stabilizing F-actin in the infected cell, which might attach to nucleocapsids and then push the nucleocapsids into the nucleus.
What are the official names of this protein?
Protein Ac132.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Virion. Note=Present in both the budded virus (BV) and the occluded virus (OV). The occluded form allows the virus to be transmitted from insect to insect through ingestion of contaminated food while the budded form is responsible for the dissemination of infection throughout the insect host.
Protein: ARLY_BACC2
Sequence: MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDIKGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSIEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIIKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLSNSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGIYLLDVPLETYKEMSPLFEEDLYEVLSPYEAVKRRNSAGGTGFEQIKNALEKAKGLTKEVIKN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPAC2_XENLA
Sequence: MAAETERKTTLEMVQAQGNEESCVTFVLHEEDHTLGNSLRYMVMKNPEVEFCGYSITHPSETKINFRIQTRNGIPAVEPFRRGLNELVDVCQHVLNTFETSIKEYKEQKEAAME
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I and III subunit RPAC2, RNA polymerases I and III subunit AC2, AC19, DNA-directed RNA polymerase I subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAX_MYCS2
Sequence: MLLAIDVRNTHTVVGLISGSGDHAKVVQQWRIRTEPEVTADELALTIDGLIGDDAERLTGASGLSTVPSVLHEVRVMLEQYWPNVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYHKYGTAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELTRPRSVIGKNTVECMQAGAVFGFAGLVDGLVNRIRDDVDGFSGADVAVVATGHTAPLVLPDLRTVEHYDRHLTLDGLRLVFERNRANQRGKLKPAR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_PHOLL
Sequence: MLKREMNIASYDPELWQAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKALFGADYANVQPHSGSQANAAVYMALLQPGDTILGMNLAHGGHLTHGSPVNFSGKLYNVVPYGIDESGKIDYDDIAAQAEKHQPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHIVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSSVFPGCQGGPLMHVIAGKAVALKEAMEPEFKAYQHQVADNAKAMVEVFLARGYKVVSGSTENHLFLLDLVDKNITGKDADAALGRANITVNKNSVPNDPKSPFVTSGVRIGTPAITRRGFKQAEARELAGWMCDVLDNINDEVTIEMIKQKVLAICAKYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_SHEPC
Sequence: METVISFTAIAVAIMIGLAALGTAIGFAILGGKFLEASARQPELAPALQIKMFIVAGLLDAISMIAVGVALFFVFANPFLAQLG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXH_EHRCR
Sequence: MIKKDPIELFDLWYNEVLAVSLQDKKDPTAMVLATCSKDLKPSARVVLLKKYSDQGFVFFTNMNSRKGKEMAENPSVALVFDWSRISKQVRIEGRIKMLPCNDADEYYASRPRGSQIGAWCSKQSSVLENREDFVELIKEMTIKFHEKPIPRPDYWVGIVVVPMLMEFWQEGLNRIHTRYQYTRDSNNMDKWNVVSLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: CHMP6_DICDI
Sequence: MGILFSHCSGGREKEDKISKTDRAVLNLKIQRDKLKNYQTQVLEIAIAKECSKAGKKNQALLALKKKKYQEKMLDESFANLQNIEELIANVEQAEIQVRIFESLKQGNESLKEIQKEMSLEDVENLMEETAEAIQYQNDISEALSGKFSKEEEDDLLNELDEMEKQLNAQQYPKVPETQLPKIELPIEDAIEEGKQRKSTTNGLNHILIIACIINHIF
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 6, Vacuolar protein-sorting-associated protein 20.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein.
Protein: PURL_CAMJD
Sequence: MDKETIKAHKISDEEYTQILEILGREPNLLELGVISAMWSEHCSYKSSKKYLNGFPTKAPWVIQGPGENAGVIDIGQGMSAVFKVESHNHPSFIEPFAGAATGVGGILRDVFTMGARVVAGLNSLKFGDIHNEKCGKHQKYLVKGVVNGISHYGNCMGVPTIGGECAFDECFNGNILVNAFALGICKSEDIFYAKAEGVGNPVIYVGSKTGRDGLGGAVMASDSFNEESKSLRPTVQIGDPFSEKLLMEACLELFKTDYIVGIQDMGAAGLTSSSFEMAGRSGSGMKLYLDKTPMRESGMTPYELMLSESQERMLICAKKGYEDKVIEIFKKWDLDAVVIGEVTNTEKMELFWHDELVGLIPIEPLSEKAPILNRPISEPKYLSEIKDYKFELKSSIQELFIQMLQNENINNKAFIYDQFDSSVQTNTIKADGKLGASVIRIKENGVSVAMAIECNSRLNYVNPKIGAALAVASAGRKVACTGAKPLAISDCLNYGNPQNPEVMWQFAQGCEGIKEACKELNTPVVSGNVSLYNETEGVSIYPSPTIVSVGVLEDANKTLKASFEKENLSVYLLGESLGEFGGSMVMKIQDKKVSGSLKELDYKAELALWDLLYKANQNSLLECANSVGIGGIAMTLAKMFAISSVGANLTSGFDDEKMIFDESASRAIVGLSKENEETFLTLTKEFGVKAYKLGVSTSQKHFKLDSIELNKAELDKLYFESFQEQIQ
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACY3_XENTR
Sequence: MSPTVQCGAVSQVVVVGGTHGNEMSGVCLAKHWLQDPSELHRKSFTAEVLLANPIAVERCVRYIDRDLNRSFSHELLSASGSESDSYEAKRAREIYQKYGPKQSSLNFVIDLHNTTSNMGTTFLLFKGDNFALHLANYLQTKCVDPSFPCHILLIDIPEGGHVHLQSMGKHSVSLELGPQPQGVARADVLTRMRALVNCSLDFLDLFNQGTEFPSFETDVHQVLYRADFPRNEDGEIEAVIHSELQDKDYLPLKPGDPIFQRLNGEDILYNGEKQIYPVFINEAAYYEKKVAFIATEKTHCLVPALKVQN
What is the function of this protein?
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
What are the official names of this protein?
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Aminoacylase-3, ACY-3, Aspartoacylase-2.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cytoplasm.
Protein: RL7_SALPA
Sequence: MSITKDQIIEAVSAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPAEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKSLEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SEC24_USTMA
Sequence: MAQPPPQLPPGWVAQWDPNAARQVFVETATGRTSWQPPTAGPAGVAPPQQHQQRPTHPQGQARMSMPQIQPPPGMRGPSLSPISQHGPGAPVSPPSAGSPAPASIGPGASRRRAYPTAHLAANSISYAGGYDASTATGAGVAYPGAQDAQPQLFTPGAPDLTPSPYGAAAQPALGAPGLAPAPGAHGAPGVGPAPGYAAGGVQGITNQFQAMGVGGGVAGGMGQKFSTLQTVNISGVQPNVNDLERPPPEIRLPPNACVSTNPKANADPSYQRCTLNAVPTTSSLLQKSKIPLGLILSPYRSVREADGDEPVPVVTDTVIARCRRCRTYINPYVTFIENGNRWKCCMCNISNEVPQLFDWNSETNQPADRWQRPELNHSVVEFIAPREYMVRPPQPPVYTFLIDVSYQAVNSGMVATAARTILETLDRLPNSDNRAKICIIGVDTSLHFFSITPEGTEPDMLVVSDLDDVFLPKPNDLLVNLTECRAGVEALLQRLGDMYKDSLVTGSALGAALQAAYKLISPIGGKIMVLTASLPSVGPGALKNREDPKLLGTAKESTLLGAASSFYKTFPIDCSRSQVSVDMFLFAPSYTDVATLSCLPRYTGGQTFFYPAFHAGRAEDAVKFSHEFSEVLASPISYEAVLRLRATKGIRATAFHGNFFVRSTDLLALPSVPLDQNYAIECEIEETINAPFVVFQSVVLHSTSSGERRIRVINLALPTTSSMSEVYANADQIAIATLLADKAVERSIHSRLEDARDALFNKLVDVFSTYKSTMTSAGSGASPQLAIAQNLAQLPLLVLALLKHVGIRQSSSIPSDLRAYAQALLTTLPAQQLIPYLHASFYCLHNMAPEAGTTVAEKGFVMPAKLNLTSERFERHGLYLIEDGQNIFLWVGREAVPQLCLDVFDVANYGTLRGGKTTLPKLDNSMNQRVNAIVQRIRDSRRGPYRPHLYIVKEDGEPSLRLWALSLLIEDRFEQSPSYMQFIGQLRDKVNGGS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC24.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YD03_SCHPO
Sequence: MPSSTTTAPPGTHPNATASTVFAILGTVCWCVQLIPQIIKNYRAKSTEGLDTLFILSWVVASIPLSVYNQVQELNIALKVQPELFQALAFTTFFQCLYYGSKWPLRKALFVVISFMLFSGGLQAMLILTIKLGIRRHVEWPVVFMGVLATVLVNIGFLPQYISIFRARAVTGISYLFLAIDSSGSLFSFLSLPFDRWDVLAAVDYGLLFIIEMGVFVLAFIFNVLLKNKSTPTDEDVTFTEEDGDEKDEEYSDIFSIKGKFNTRPNAWQNAYDSDTKSAIQIP
What are the official names of this protein?
Uncharacterized protein C2E12.03c.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SF33K_ADE40
Sequence: MPPKGNKHPIAQRQSQQKLQKQWDEEETWDDSQAEEVSDEEAEEQMESWDSLDEEDLEDVEEETIASDKAPSFKKPVRSQPPKTIPPLPPQPCSLKASRRWDTVSIAGSPTAPAAPTKRLEKTPRVRKTSSAIATRQDSPATQELRKRIFPTLYAIFQQSRGQQLELKVKNRSLRSLTRSCLYHRSEDQLQRTLEDAEALFNKYCSVSLKD
What is the function of this protein?
Probably functions as the small terminase that is part of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging.  This motor is located at a unique vertex and comprises at least the IVa2 ATPase, the small terminase 33K and probably a portal.  Forms a ring-like structure of about 17 nm in which genomic DNA is translocated into the capsid.  Stimulates IVa2 ATPase activity in the presence of the viral genome.  Once the DNA is packaged, the terminase detaches: the 33K protein is present in the empty particles, but not in the mature virions.  Also involved in virion assembly.
What are the official names of this protein?
Protein 33K, L4-33K, Splicing factor 33K, Terminase, small subunit.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae splicing factor family.
What are the subcellular locations of this protein?
Host nucleus. Note=At late time of infection, reorganized from the nuclear margin to ring-like structures at viral replication centers.
Protein: LPXK_SHEPA
Sequence: MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVGGSGKTPTVIYLIELLRSHGFKPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTAVPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDIELIILDGERRLGNGMLLPAGPLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAGIGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKDNWWSLAVDAKLSPSFDKQLLAKIDRLVADK
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: SRBS2_RAT
Sequence: MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESHSPDSAWRSYNGRNPETLNGDATYSSLAAKGFRSVRPNLQDKKSPTQSHITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMPHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDEDTDMYNTPYTYNAGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEATSPVPPPHVPPRPRDQSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSVYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPPRGLGDHSSSRTSPGRADLPGSSSTFTTSFISSSPSSPSRAQGGDDSKMCPPLCSYSGLNGSPSSELECCGAYRRHLDVPQDSQRAITFKNGWQMARQNAEIWSSTEEAVSPKIKSRSCDDLLNDDCGSFPDPKTKSESMGSLLCDEGSKESDPMTWTSPYIPEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPVTLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDNVHVERSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHGHFISSCKGRCPASYTRFTTMLKHERAKHENIDRPRRQDMDPGLSKLAFLVSPVPFRRKKVLTPQKQTEQAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPKRNSSLNALKRSPMHQPFHPLPQDGAIHCPLYQNDCGRMPHSASFPDVDTTSSYHAQDYGSVLSLQDHESPRSYSSTLTDLGRSVSRERRGTPEKEVKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNTKGSEDYPDPPLPHSYSSDRIYSLSSNKPQRPVFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
What is the function of this protein?
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton.  Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity).  May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity).  Isoform 2 increases water and sodium absorption in the intestine and gall-bladder.
What are the official names of this protein?
Sorbin and SH3 domain-containing protein 2, Arg-binding protein 2, ArgBP2, Arg/Abl-interacting protein 2, Neural ArgBP2, nArgBP2, Sorbin.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Note=Detected in the stress fibers, synaptosomal cytosol, postsynaptic density fraction, Z-disks and intercalated. The CBL/PTK2B/ARGBP2 complex is recruited to lipid rafts following growth factor stimulation. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells.
Protein: CARL3_MOUSE
Sequence: MAKASVELTRELQDSIRRCLSQGAVLQQHRVKLETKPKKFEDRVLALTSWRLHLFPLKVPAKVESSFNVLEIRAFNTLSQNQILVETERGTVSMRLPSAESVDQVTRHVSSALSKVCPGPGCLIRRGNADTPEGPRDTSPNSETSTSTTHSVCGGFSETYAALCDYNGLHCREEVQWDVDTIYHAEDNREFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQKLAGVFGENGSCVLHALILSHNPIEDKGFLSLSQQLLCFPTGLTKLCLAKTAISPRGLQALGQTFGANPAFASSLRYLDLSKNPGLLATDEANALYSFLAQPNALVHLDLSGTDCAVDMLLGALLHGCCSHLTYLNLARNSCSHRKGREAPPAFKQFFSSVYTLSHVNLSATRLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQLGAVTCIGSLDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNFNVKAKTLEEILHKLVQLIQEEDCSLQSLSVADSRLKLRTSILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNHTLRFMSFPVSDISQAYRSAPERTEDVWQKIQWCLVRNNHSQTCPQEQAFRLQQGLVTSSAEQMLQRLCGRVQEEVRALRLCPLEPVQDELLYARDLIKDAKNSRALFPSLYELGHVLANDGPVRQRLESVASEVSKAVDKELQVILESMVSLTQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQELYHSHKSLARHLTQLRTLSDPPGGASQGQDPSSRGRGRNHDHEETDDELGTNIDTMAIKKQKRCRKIRPVSAFISGSPQDMESQLGSLGIPPGWFSGLGASQTTASGSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSVPVPGPRQENGMATRLDEGLEDFFSRRVMDESSSYPRTLRTMRPGLSEPPLPPLQKKRRRGLFHFRRPRSFKGDRGPGSPTAGLLLPPPPPPPPTQESPPSPDPPSLGNNSSPCWSPEEESSLLPGFGGARGSSFCRKMGTERLEAGEGAPAPGTAQQPRVHGGVALPGLGRTKGWSFDGKREGTDPDQEDSTQAWQKRRSSDDAGPGAWKPPPPPQSSKPSFSAMRRAEATWHIAEESAANHSCQSPSPASQDGDEEKQGALFPERMVPTRNAKLQEPPIGPRPPKPVAVPRGRRAPQVPGGREETESSSAAPGANKPRLRLGSQQDQEEPEGQGPTDQGRRTAPLKPKRTRRAQSCDKLEPDRRQPPDPTGVCGTSEPGTD
What are the official names of this protein?
Capping protein, Arp2/3 and myosin-I linker protein 3, Capping protein regulator and myosin 1 linker protein 3, Leucine-rich repeat-containing protein 16B.
What is the protein family that this protein belongs to?
Belongs to the CARMIL family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.