PharMolix/UniProtQA huggingface dataset:
Protein: TM45B_XENLA
Sequence: MANFKGHALPGSFFLVFGLWWSVKYPLRYLNSKVKGNCRSNKCYDRLELIEGILKALFSLIGILAEQFVPDGPHMHLVNGEDHSWVKLMNWQHTTMYLFYGISGVVDILTYFPLNLPRGLDRLSLGIAVIVEGLLFYYHVHNRPALDQHIHSLLLIAVFGCAISIMIEVFMRNDIVLELFRASLSILQGTWFWQIGFVLYPLGGAPEWNQTDHDNVMFITMCFCWHYAVALLIMAINYSLVYYCVNRHKKLPVIVDNGLIKINSKKAEVEASLLAGSDEE
What are the official names of this protein?
Transmembrane protein 45B.
What is the protein family that this protein belongs to?
Belongs to the TMEM45 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CP6G1_DROME
Sequence: MVLTEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMRSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEIVNDRLYDQSAPSLQ
What is the function of this protein?
Necessary and sufficient for resistance to insecticides DDT and imidacloprid.  May be involved in the metabolism of insect hormones.
What are the official names of this protein?
Cytochrome P450 6g1, CYPVIG1, Cyp6-like protein.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: VPHE_NPVLD
Sequence: MSAPHNVLTKKNPRRGRFAFPRRRVRAGSIDEVVQLLRLPANIANGIHTRHKKCWNDFRGGGGGGGGSRVDGTRAFVDLYGLGYLCNRTNSTLADYLCTLFVAEAYRDACCAQPPAPFPDYNASPPDCRPPLPPQPPCKPNDSELLDRIVRQNDLILNGLNQLCLNHSNHHFELSNILNSIKLQNVNIINQLSQIFDDGVLSGLDEKLSRLIADLDGHFADFGSALDAALAQLQDSLRNDLTNINSILANLTSSLTNINSTINNLLQTLQNLGLGEVGAKLNDVQSTVDRILGVLTPEIVAAAAAAAAKRAH
What is the function of this protein?
Major component of the polyhedra envelope.
What are the official names of this protein?
Polyhedral envelope protein, PE, Polyhedral calyx protein.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae PE family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: ELOA_DICDI
Sequence: MEHIHDINFQEFSKDPIGTIDRFRWKNEVTPFSNILFPIVCSFGYLALIYGLQIFMKNKKEIKLHGFAMFHNLFLCLLSLLMFLGIVIPMAKYSFPHGLYNIICKPIDSGLVQFSYYIFYLSKVYEFIDTIIQVLRKKSLLFLHVWHHFITLWLVWANLKYDTGCQWVDISANCFVHIVMYFYYFQTERGINPWWKKHITTCQIIQFIVDMSSHLAWHFYDTQGNHNSNYCSGTWATSAFSDFVILSFLGLFIQFFVKAYKKKSSIKKKTN
What is the function of this protein?
Fatty acid elongase with strict substrate specificity for monounsaturated fatty acids, in particular 16:1 (delta-9) to produce the unusual 18:1 (delta-11) fatty acid.
What are the official names of this protein?
Elongation of fatty acids protein A, 3-keto acyl-CoA synthase eloA, Fatty acid elongase A, Very-long-chain 3-oxoacyl-CoA synthase A.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: WASH4_HUMAN
Sequence: MSGVMCLKASDTWASGIRSQPQGCLGKWRSMRCKHTRMHLAHLGNSRQLISLGPPRTREDGSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTDAQDPGLQRRPRHRIQSKQRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKQQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGDGPGGAFARVSDSIPPLPPPQQPQAEDEDDWES
What is the function of this protein?
May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
What are the official names of this protein?
Putative WAS protein family homolog 4, Protein FAM39CP.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2.
Protein: GP108_MOUSE
Sequence: MAVSERRGLSGESPTQCRWGYLSLLVLTLSGCSGRIHRLTLTGEKRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKKLPKVGFSLSRVRSGSVRSYSRRNSHECPLDRNSSNFLVLFLINIKDLQVQVRKYGEQKLFISPGLLPEAPTQSGPPKPDPAGTPKDNHVIHPSPTEMSAVKENQTAPQVSGDKTTPGEHRHSSERQPPTQDPSGKEKDQVLGLGHLNDSYNFSFHIVISSRAEEGQYSLNFHNCHNSIPGQEQPFDLTVMIREKNPEGFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFKIHWLMAALAFTKSVSLLFHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFVKYMLSDKEKKIFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVESSTLAFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
What is the function of this protein?
(Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction, across multiple serotypes except AAV5.  May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.
What are the official names of this protein?
Protein GPR108, Lung seven transmembrane receptor 2.
What is the protein family that this protein belongs to?
Belongs to the LU7TM family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Colocalizes with TLR3, -7, -4, and -9.
Protein: RSMH_MYCSJ
Sequence: MKLCATSSEPARAAWPLSEPALAYFPDARSASDRDLAAGAYSPGVAMEHIPVLLDRCVELLTPALTRRNPDGRGAVLVDATLGAGGHAHRFLSDLPGLHLIGLDRDPQALQIAGERLAPFGDRVSLVRTRYDGIDDALAQTGVAEVSGFLFDLGVSSMQLDRTERGFSYSADAPLDMRMDSDAPLTAADVVNTFAEKDITRILREFGEERFAARIAKHIVRRRPLNTTGELVELLYDAIPAPARRTGGHPAKRTFQALRIAVNSELDSLRAAIPAALGALETGGRIVVMAYQSLEDRIVKTEFAAATASRTPPGLPVELPGHEPEFVALTRGAERATPEEIERNPRSAPVRLRALEKVAGRPTTARRDAR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX17B_MANRB
Sequence: MENSRTSTFTAYVTVAFLLISTFVTMVVTESQIVWVPCNPRSKKTDDAGICRNTY
What are the official names of this protein?
U17-myrmicitoxin-Mri1b, U17-MYRTX-Mri1b.
What are the subcellular locations of this protein?
Secreted.
Protein: AROB_CHLTE
Sequence: MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIELVVPARETSKSVSTAWKLYGQMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQLPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLIDPAYLRTLPSREIYGGMSEVVKYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNFGHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRGLVNKRFLSLDRDELVESMLSDKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAMGWFSSAGF
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB1_LEGPL
Sequence: MPNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAVTGLTEIIPFLKIFRKAFQDIKQHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGLKIIYYISPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPVSFVGHPLVKKIAAAKDKHSSRTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDSPKLRFVVPIAGTINPDKVKAYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAAMYFIKVKFLGLCNLLANKMMVPEFLQYDCNAIELSRYISNFHNNPNQPESMINQLAKLKESLSSSQADCSLFDLVVAELPEKNA
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: CLSA_KLEP7
Sequence: MTTFYTVVNWLVILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSFGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEDNSPVAESLFKLCERRQGIGGVKGNQLQLLTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADSVAESLMAAARRGVHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSMNMVDPRYFKQDSGVGQWIDLMARMEGPVATSMGIVYSCDWEIETGKRILPPPPDVNIMPFEEASGHTIHTIASGPGFPEDLIHQALLTAAYAAKEHLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDAGFGSDLAAVQDDYISRSRLLDARLWLKRPLWQRIAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOB_NEIMF
Sequence: MGIEGVLKKGFITTSADTVLNYMRTGSLWPVTFGLACCAVEMMHAGMARYDLDRFGIIFRPSPRQADLMIVAGTLTNKMAPALRRVYDQLAEPRWVLSMGSCANGGGYYHYSYSVVRGADRVVPVDVYVPGCPPTAEALIYGLIQLQQKIKRTSTIARDE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PVK1_CHRSK
Sequence: QGLIAFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LCL2_PICST
Sequence: MIRVISLFLVFVSLASANIFDFLNNNFAGRGQQQGGQVQTPEQYENAILNTNCGKYVCPDTGMCVEAPKFCPCPYPSSQLRCFLPDGRYLCISKPAGDISAKYDDPKSNWKVDAKDDNIRDCGWVSRAWRGLV
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: KDSA_STRMK
Sequence: MKLCGFEVGLDQPLFLIAGPCVIESMQLQLDTAGKLKEVTDKLGVNFIFKSSFDKANRTSGTAFRGPGMEEGLKVLAEVRKQIGVPVLTDVHEYTPMDEVASVVDVLQTPAFLVRQTDFIRKVCSAGKPVNIKKGQFLAPWDMKPVVEKAKATGNEQIMVCERGASFGYNNLVSDMRSLAVMRDTGCPVVFDATHSVQLPGGQGTSSGGQREHVPVLARAAVAVGISGLFAETHPDPSKALSDGPNAWPLDQMEALLETLMELDAVTKKHGFSRFA
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATA_LATSK
Sequence: MTNQLTTNEGQPWADNQHSQTAGQRGPVLIQDYQLLEKLAHFNRERIPERVVHAKGAGAKGYFKVTKDMSAYTKAAVFSGVGKKTPLITRFSQVAGEAGYPDTYRDVRGFAVKFYTEEGNYDIVGNNTPVFFVNDPLKFPDFIHSQKRDPRTHARSQDMQWDFWSLSPESVHQVTILMSDRGIPASYRMMHGFGSHTFKWVNAQGEQFWVKYHFKTNQGIHNLSNELADELAGKDTDYLQNDLFDAIETGDYPSWTVAVQLVPYEDGLNYPQDIFDVTKVISQKDYPLIEIGQMVLDENPTNNFEDIQELAFSPANLVPGIEASPDKLLQGRLFGYKDAERYRLGANYEQLPVNRPKVPVHNYERDGAMAQNQATGVNYEPNSQDGPTEVPAAKIHGDQLSGTTGNFSADPDYYSAAGKLYRLLSADEQTRLIENIRMNLGQVTKPEIQIREVKQFYQADPEYGRRVATSVKLRFSSV
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPRA1_CAEEL
Sequence: MSVIFHENPGTSLGSVVPDTNTSFERESQLSVKTSPEWIDELFPNVSFIDSPTHQVIRGFCRDVFVYRLPGGFRVRYWDAVILVPNILFLLFLILKCGSVIRKLRTGNSPVLRAFTLLVYVSTLVNIIRCAYSMTLSMTDGLEQTVDQTLWIIIKFFYLTAEFCALTFGLLFGHLDNGKSILIALLGTLLVSIPHTAVQVIIEMKIIDNSWLPLTYFDIQSDGGFLFWVFSSAVLALVYFFIMCLPLVCCQKYTKLPSKGSFLIYCMMMVVLNVLQSMGAALILFKSSDGLCFVGVSTYVYFVLYPPIIYFTFLRKKLKTPPNNTSGLFMYRKHKDEQGSGDLPDSYYPRFSGLTSPSYDDLFDYDRDARFTHYDISRNEYVQNPHYNTYSTPLIMTSVETAESTVTTRTGSDDYAHHRDSMLSEPSTGTTTRHLKGLGPQGSLVFEDDPSSLTSLRM
What are the official names of this protein?
Transmembrane protein adipocyte-associated 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0359 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IL27B_HUMAN
Sequence: MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK
What is the function of this protein?
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity.  IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.  Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17).  It drives rapid clonal expansion of naive but not memory CD4 T-cells.  It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR.  Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
What are the official names of this protein?
Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VP4_ROTF6
Sequence: MASLIYRQLLTNSYTVNLSDEIQEIGSTKTQNTTINPGPFAQTGYAPVNWGPGETNDSTTIEPVLDGPYQPTSFNPPVGYWMLLSPTTAGVIVEGTNNTDRWLATILIEPNVTSQQRTYTIFGVQEQITVENTSQTQWRFVDVSKTTQNGSYSQYGPLLSTPKLYAVMKYGGRIHTYSGQTPNATTGYYSATNYDSVNMTTFCDFYIIPRSEESKCTEYINNGLPPIQNTRNIVPLALSARNVISLKAQSNEDIVVSKTSLWKEMQYNRDITIRFKFANSIVKSGGLGYKWSEISFKPANYQYTYMRDGEEVTAHTTCSVNGMNDFSFNGGSLPTDFVISRYEVIKENSYVYIDYWDDSQAFRNMVYVRSLAANLNSVTCTGGDYNFALPVGQWPYMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLAVEEPSFAIMRTRVSGLYGLPAANPNNGREYYEIAGRFSLISLVPSNDNYQTPIANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSIATNVMKKFKRSSLASSVSILTDSLSDAASSVSRGSSIRSVGSSVSAWTDVSTQITDVSSSVSSISTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDKSVQISPTTLPDIVTEASEKFIPNRAYRVINNDEVFEAGTDGRFFAYRVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGIGKQQAFNLLRSDPRVLREFINQNNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: SAP25_HUMAN
Sequence: MTPLAPWDPKYEAKAGPRPVWGANCSSGASFSGRTLCHPSFWPLYEAASGRGLRPVAPATGHWNGQQAPPDAGFPVVCCEDVFLSDPLLPRGQRVPLYLSKAPQQMMGSLKLLPPPPIMSARVLPRPSPSRGPSTAWLSGPELIALTGLLQMSQGEPRPSSSAVGPPDHTSDPPSPCGSPSSSQGADLSLPQTPDTHCP
What is the function of this protein?
Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.
What are the official names of this protein?
Histone deacetylase complex subunit SAP25, 25 kDa Sin3-associated polypeptide, Sin3 corepressor complex subunit SAP25.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: CUTC_VIBVU
Sequence: MSYQVEVCIDNIESLHNALEGGATRIELCSSLALGGLTPSYGFMTLAAKLSTVPIYAMIRPRQGDFLYSDDEFAIMQQDILSAQQAGLQGVVFGLLTADGDIDVARTRILVELAHSLQLGVTFHRAFDQCREPFAALEQIIDLGCERILTSGLAASAPLGKEILTQLVAHSQSRLAIMAGAGVSPVNVADLALTTGVKEVHLSGKSTRPSKMTFIASDSKMGAADQDDFIIPITHTATIRNTVLALKSIS
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLMH_BACSU
Sequence: MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQVILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVDHRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKIDLSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPSYIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK
What are the official names of this protein?
Putative RNA-binding protein YlmH.
Protein: RS5_BDEBA
Sequence: MEKVQAQAAELEERVVAINRVTKVVKGGRRFSFAALVVVGNKAGDVGFGSGKAGEVPEAIGKASRSAKKSAKSVALKEGRTIPHEVIGKFGAAKVIMKPAAPGTGVIAGGAVRAVLESVGVKDILTKCVGTRNPHNAVRATIDGLKQLKQQL
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TPC1_MOUSE
Sequence: MAVSLDDDVPLILTLDEAESAPLPPSNSLGQEQLPSKNGGSHSIHNSQVPSLVSGADSPPSSPTGHNWEMNYQEAAIYLQEGQNNDKFFTHPKDARALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPVLKLHTYVHATLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDPYFSTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFKSLLLHKRTAIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFYYSFAIVGMEFFNGRLTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKSQDSEVDSGIVIEKEMSKEELMAVLELYREERGTSSDVTRLLDTLSQMEKYQQNSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQKLRGSVPGPAAQQPPGSRQRSQTVT
What is the function of this protein?
Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:24776928, PubMed:23394946, PubMed:23063126).  Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (PubMed:28855648).  Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (By similarity).  Required for mTOR-dependent nutrient sensing (PubMed:23394946).
What are the official names of this protein?
Two pore calcium channel protein 1, Voltage-dependent calcium channel protein TPC1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Protein: RL13_CORGL
Sequence: MSTYHPKSGDITRKWYVIDATDVVLGRLATHAADLLRGKGKPLYAPNVDCGDHVIVINADKVAVTSNKREREMRYRHSGYPGGLKSMTLGRSLDLHPERTIEDSIVGMMPHNKLTAASAKKLHVFSGSEHPYAAQKPEAYEIKKVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: DXR_MYCPA
Sequence: MTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAGGANLDTLLRQRAETGVTNVAVADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGALGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQIVPVDSEHSALAQCLRGGTGDEVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAACCDFSTASSWEFEPLDNEVFPAVELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAIVETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQRAVAQARPATASAKTPGVV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.