Protein: YANA_ASPNA
Sequence: MSASRSSTKFSTPAEGSDNGKEFTTPATSTEGHEVPDRPGDALADVAIIGMACRTPGDVRSPDSLWQYLLKKGDASGSLPDWRWEPYRQRHPRNAALLAQTTAKGYFLDDIDHFDAAFFSISPREAEQMDPQQRLALEVAWEALENAGISPPQLAGSNTSVYMGVNSDDYAKLLLEDLPNVDAHMGVGTAYCGIPSRISYILDLMGPSVALDAACASSLVAVHHARQAIRAGETDLAIAGGVNALLGPGLTRVLDEAGAISTDGKCRSFDETASGYGRGEGAGVVILKRLDKALADGDHVLAVLKGSAVASDGKTLGIMAPNARAQLLVAQKALAEAKVSADSINYVEAHATSTSLGDPTETNALAEVYGAGSGRSPSDPCYIGSIKPNIGHLEAGAGVMGLIKAVLVLRHGQVPPQANLKTLNSKIAWNENLLCPPRELVTLPCPGPIHPLRAAVASYGYSGTVSHAVLEAFAGHSEFAERLSQIPTGDDPSPVLLLISAPQARRVSAAAGALKQWLSENEASISLKTVSSTLAQRRAHHRYRHAIVADSVPDAIAALDDVSKEAPNRWVIKDKIDSKAAKGPVWIFSGHGAQWADMGRELFESSPAFEEVVRNLEPIIQDEVGFSAIETLQKGCPDRSDVVQVMTFLMHLGIAAVLEIESGPPSAVVGHSLGEAAAAVVSGALTWREGALVVCRRARLYRELMGQGAMALVRVSAEEARTRIGRQTGVWVAIETSPSACVLSGEVDAIKQLSDRWREEGIEVRMVASDVPFHTPMLERLAKPLYESLRGELHPRVPNRALFSTSQPDPRSEVLRDAQYWVTNMIQPVRLQSAIAAIAQDGFRALVEVSSHPIVTHSVVETMGECTEDPVLVTPTMVRRQPALKSILAATGRLHCFGCAIKFIELDPNAPWNSSVPSTVWHHQPFYRAVSQTSASSQLETTHDPAANNLLGKRIALWGTEEVLYQTRLEEENRPFPGHHPLHGSEIVPAAVLLRTFLQALTPRCVEQVSLQVPVVVSPARKVQIRHNTRNITITSCLEESSSQEDGSWLVNTTAAVGAANVVPSQSRMDLSELRKRLPQKLADSFSIDYLASVGVSAMGFPWQVTHHVASDDEMLARVDANPDNMGGMNDFLTSLMDAATSISSTLWHRQPLLRMPTSVRRVVAVHEIPIPRVVYIHCTKVASTSECTADVTLTGEDGTVLMEIQGMSFAGLEGESFSRKSTAGLVHQIQWPPAALVEDPSEFSHIAFVTPDITDPRLEQYQSQLDALAITSSVHQAASDLPLTSHTSLAVVYLPQTMTDVFDTATRSCNDLVSIIQTITAAASSTTRVFVLTAGTELGHSALLGLSRIIQAEHPDIWGSLIEVEDTFSLPLMAMRYVRDADVIRIKDGVPRIARLRPLPSASSSLTPLTFSPASTYLITGGLGALGLSVAHWMVTQGARRLLLLSRRALPPRSTWSSTHMNNPTIQSILALERLGATVHCLPIDISLPMAASGLRSTLETLNLPSVAGVIHAAGIVSDQLVEQVTPDVLESVLAPKIKGALNLHDVFPPASLDFFVLFSSCGQLLGFPGQASYASGNAFLDGLARSRRAQGDNAISLLWTTWRGMGMGQSANGAMEAELYARGITDITPDEAFRAWSAVASTGGGGTDHAVIVRARVLEGGEPLPHPILTDIATRKAEVVNAGEHPAGSQEVKLSGRELEQHLRDVINGCVSKTLSVKEDEIDDAVALAEMGMDSVMTVNFRMTLQQTLKVPVGPTLIWKCPTVQHLVKHFTKELDA
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria (PubMed:24684908).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA (PubMed:24684908).  6-MSA is then converted to m-cresol by the decarboxylase yanB (PubMed:24684908).  The cytochrome P450 monooxygenase yanC then catalyzes the oxidation of m-cresol to toluquinol (PubMed:24684908).  Epoxidation of toluquinol is then performed by the short chain dehydrogenase yanD, with the help of yanE, and a further prenylation by yanG leads to 7-deacetoxyyanuthone A (PubMed:24684908).  The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase yanH to yield 22-deacetylyanuthone A (PubMed:24684908).  O-Mevalon transferase yanI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (PubMed:24684908).  Finally, the FAD-dependent monooxygenase yanF oxidizes the hydroxyl group at C15 of yanuthone E to form yanuthone D (PubMed:24684908).  Furthermore, several branching points in the pathway lead to the production of yanuthones F and G from 7-deacetoxyyanuthone A; yanuthones H and I from 22-deacetylyanuthone A; and yanuthone J from yanuthone E (PubMed:24684908).
What are the official names of this protein?
6-methylsalicylic acid synthase, 6MSAS, Non-reducing polyketide synthase yanA, Yanuthone D biosynthesis cluster protein A.