PharMolix/UniProtQA huggingface dataset:
Protein: Y2012_STAHJ
Sequence: MFPLVEFCISNMAKGGDYVYDKLENDPDVDVLEYGCLNNCSVCSCGLYALVDGDTVEGDTPDELLKNIYKHIEENDFTNLL
What are the official names of this protein?
UPF0349 protein SH2012.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: SYS_HELHP
Sequence: MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFGEYKREQKDITALKVALDENKVKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDENDNVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAKSRFSVLRGMGAKLNRALINFMLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSEITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPTQSAAMQEKMVQTASEILSELKLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSISNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIAIMENYQQVDGSVMIPEVLQKYL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LLDD_ECO45
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQVLGKELPAALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYR_NITMU
Sequence: MIPPVQPDFKSHFTDILRNALNERGLADLNLDIEFARPRQSSHGDYSCNLAMQLAKPLRQKPRDIAQSLATAFSASPYLEKVEIAGAGFINLFLTTSAKQQFSRYVLESGEKFGHSSMGAGEKIQVEFVSANPTGPLHVGHGRGAAFGASLANVLAAAGYSVTREYYINDAGRQMDILALSTWLRYLELNGVASAFPPNAYQGEYVRDMARLIHKAHAGRYVHEPELLFDRVAGAEADTEAALDGLIANAKKLLGQDYAYIHNFVLNEQLGDCRNDLMEFGVTFDIWFSEQSLFDSGGVAQAVHLLEEGNYLYQQDGAKWFRSSHFGDEKDRVVQRENGQFTYFASDIAYHLNKFSRGFDRVIDIWGADHHGYISRVKGAMQALALDPEKLEIALVQFAVLYRDGKKVPMSTRAGEFVTLRELRQEVGTDAARFFYVLRKSDQHLDFDLDLAKSQSTDNPVYYVQYAHARVCSVLEQWGEDPGMLVTADTSALTGAAELSLLQKLIDYPETVEAAAREFSPHLIAFYLKELAGEFHSYYNSTRFLVPEMTVRLARLALVAAVRQVLNNGLKLLGVSAPAKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_RICCN
Sequence: MLIGVGTDIVQIPRIEKILHLYPELFAKKILTSKELKQFALLGKINHAAFLAKRFAAKEAVSKAFGVGIGQGINFKDITILNNDLGKPIVEVSSNYTNTLSPFNIHLSLADDYPVCVAFAVIESSYNVILG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_RICAE
Sequence: MRTEIENYVKKIEQSLELLWRSLDVEASTERLNALEELTADPSLWNDQANAQKLLREKSNLEEKLNAFNKLKSNLKDALELEEMAEAENDLETLSQIEQDLKNLSIIAAKFETECLFSGEADGNNCFLEINAGAGGTESHDWASIMMRMYLRFAERLGFKTEIINMINGEEAGIKSCTIRIIGKRAYGWFKTETGVHRLVRISPFNAAGKRMTSFASSWVYPEIDDNIAITIEDKDLRIDTFRASGAGGQHVNTTDSAVRITHIPTGTVTQCQSDRSQHKNKAQAMKMLQAKLYELEMQKRTDSVNEQNATKTDNSWGHQIRSYVLQPYHMVKDLRTDYETSDTKGVLDGDLEEFVSANLAMNVGGKK
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_CLOBL
Sequence: MSKNSVIIVAAGKGKRMNSSISKQFLQIKNKPILYYTLSKFSAHESIDEIVLVTLEDKIEVCSDIIDKYNINKVSKIVPGGKERQDSVYNGLKAVSKDCEVVLIHDAARPFVTSDIIENGIRCANQYGAAACGVIPKDTIKIKNEKEFAIDTPNREDLFIVQTPQCFNYNIILDCHEKLKKHNKKVTDDTMVLENYGKSVYLYEGSYSNIKITTPEDLILGEQILEKLT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: Y332_THEAB
Sequence: MFGLINIGFGNVIAGDRIVAIVNPESAPLKRLKEDAKEEGKLIDATYGRKTRAILISDSNHIILSAIQPETIAQRFMQSFFEIEEQLDKIRRKG
What are the official names of this protein?
Putative regulatory protein THA_332.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: CSPLA_MAIZE
Sequence: MAAAARVSEVKAEGLLRGACAALAAAAALLVGLSTQTETVLLVRKKATVKDVQALWVLAMAAAAAAGYHLLQLLKCLYLGRVGGARPCRRSSRALAWTCLLLDKACAYTTFATTVAAAQACVVALDGAHAVQWTKLCNIYTRFCEQVAGSLVLGMLAAVGTAVLSAASARNVFRHYSSLETYAAH
What are the official names of this protein?
CASP-like protein 2C3, ZmCASPL2C3.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YAB5_ARATH
Sequence: MANSVMATEQLCYIPCNFCNIILAVNVPCSSLFDIVTVRCGHCTNLWSVNMAAALQSLSRPNFQATNYAVPEYGSSSRSHTKIPSRISTRTITEQRIVNRPPEKRQRVPSAYNQFIKEEIQRIKANNPDISHREAFSTAAKNWAHFPHIHFGLMLESNKQAKIA
What is the function of this protein?
Promotes adaxial cell identity.  Regulates the initiation of embryonic shoot apical meristem (SAM) development.
What are the official names of this protein?
Axial regulator YABBY 5.
What is the protein family that this protein belongs to?
Belongs to the YABBY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIR1_EBVB9
Sequence: MATTSHVEHELLSKLIDELKVKANSDPEADVLAGRLLHRLKAESVTHTVAEYLEVFSDKFYDEEFFQMHRDELETRVSAFAQSPAYERIVSSGYLSALRYYDTYLYVGRSGKQESVQHFYMRLAGFCASTTCLYAGLRAALQRARPEIESDMEVFDYYFEHLTSQTVCCSTPFMRFAGVENSTLASCILTTPDLSSEWDVTQALYRHLGRYLFQRAGVGVGVTGAGQDGKHISLLMRMINSHVEYHNYGCKRPVSVAAYMEPWHSQIFKFLETKLPENHERCPGIFTGLFVPELFFKLFRDTPWSDWYLFDPKDAGDLERLYGEEFEREYYRLVTAGKFCGRVSIKSLMFSIVNCAVKAGSPFILLKEACNAHFWRDLQGEAMNAANLCAEVLQPSRKSVATCNLANICLPRCLVNAPLAVRAQRADTQGDELLLALPRLSVTLPGEGAVGDGFSLARLRDATQCATFVVACSILQGSPTYDSRDMASMGLGVQGLADVFADLGWQYTDPPSRSLNKEIFEHMYFTALCTSSLIGLHTRKIFPGFKQSKYAGGWFHWHDWAGTDLSIPREIWSRLSERIVRDGLFNSQFIALMPTSGCAQVTGCSDAFYPFYANASTKVTNKEEALRPNRSFWRHVRLDDREALNLVGGRVSCLPEALRQRYLRFQTAFDYNQEDLIQMSRDRAPFVDQSQSHSLFLREEDAARASTLANLLVRSYELGLKTIMYYCRIEKAADLGVMECKASAALSVPREEQNERSPAEQMPPRPMEPAQVAGPVDIMSKGPGEGPGGWCVPGGLEVCYKYRQLFSEDDLLETDGFTERACESCQ
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, R1, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: HEM2_YEAST
Sequence: MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: RPOA_MYCSJ
Sequence: MLISQRPTLSEETVADNRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPEMHIATLNDKGKLEVELVVERGRGYVPAVQNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKNSITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPATFDPSEVAGYDAATGTWNSDAGYDLEDNQDYAETEQL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: PCTC_PSEAE
Sequence: MLRSLSFAKKILLAAALVVVFAFSCFILYNDYRQREAVRTDTENYLGEIGTLTASNIQSWLEGRMHLVEGLASQLALLDQPDEANIARQLEQPVFSRNFASVYLGEAASGTFTMRPYDAMPEGYDPRTRAWYKDALAADRLIVTEPFVDAGTGEQILAMSLPVRHAGQLLGVAAGDMKLETLTAILNSLKFDGAGYAFLVSDAGKILLHPDSGLVLKTLAEAYPKGAPNIVPGVHEVELDGSSQFVSFTPVKGLPGVTWYVALVLDRDTAYSMLSEFRTSAIVATLIAVVGIMLLLGMLIRVLMQPLTDMGRAMQDIAQGEGDLTKRLKVTSNDEFGTLANAFNRFVERIHESIREVAGTARQLHDVAQLVVNASNSSMANSDEQSNRTNSVAAAINELGAAAQEIARNAADASHHASDANHQAEDGKQVVEQTIRAMNELSEKISASCANIEALNSRTVNIGQILEVIKGISEQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLAHRAQESAQQIQKMIEELQVGAREAVATMTESQRYSLESVEIANRAGERLGSVTSRIGEIDSMNQSVATATEEQTAVVDSLNMDITEINTLNQEGVENLQATLRACGELETQAGRLRHLVDSFKI
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  Responds to L-His, L-Pro and gamma-aminobutyrate (GABA).  Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate (PubMed:16233808, PubMed:23650915, PubMed:9353923).  Also mediates chemotaxis to histamine, but does not bind histamine (PubMed:30425146).
What are the official names of this protein?
Methyl-accepting chemotaxis protein PctC.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METAA_LACE2
Sequence: MPIKIQSDLPAKAELEEENIFVMDENRAISQNIRPLEIIVLNLMPIKQDTELQLLRGLSNTPLQIDVTFLQMSSHVSKNTSASHIKKFYQTFEEIKNNNYDGMIITGAPVEKLDFEEVNYWDELITVMEWSNKHVTSTIHICWGAQAGLYYHYGIKKELLPKKLSGVYKHRVMNRKEPLVRGFDDVFMAPHSRYTQASRQQILDNPRLKVLADSDEAGIYIVLGDGGKEIFVMGHPEYDRLTLDQEYKRDIDKGIEPDLPVNYYPDDDCNRKPLLSWRSHANNLYTNWLNYYVYQITPYDLNESYDNYCI
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PHAVU
Sequence: MGINPTTSGPEVSSREKKNLGHIVQIIGPVLDVAFPPGKMPNIYNALVVKGRDTVGQQINVTCEVQQLLGNNRVRAVAMSATDGLMRGMEVIDTGTPLSVPVGGATLGRIFNVLGEPIDNLGPVDTRTTSPIHRSAPTFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSAGKYVGLVETIRGFNLILSGELDSLPEQAFYLVGNIDEATAKATNLEMESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: EDN1_CAVPO
Sequence: AAETVVSGAELSLTANSGGEKTPPHAPGLLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPGHIAPYGLGGPFRSKRSLKELFPTKATEHRNRCQCANQKDKKCWNFCQAGKELSSQDTMQKGWDNHKKGKDCSKLGKKCISQQLGNGKK
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTH_PSESM
Sequence: MTAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVNLVPERKFFGLTGRFTHQGQDVRLLIPTTYMNRSGQAVAALAGFYRIPIESILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQEKLDASIDFALGVLPDIFAGEWNRAMKNLHSQKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP8_XENLA
Sequence: MPQLNPGPWFLILIFSWLVLLTFIPPKVLKHKAFNEPTTQTTEKSKPNPWNWPWT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: DCDA_NEIMA
Sequence: MTLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSIIKHFASLGSGFDIVSGGELARVLAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIPEIDRIQKVAARLGKTASVSLRVNPDVDAKTHPYISTGLKANKFGIAYADALEAYRHAAQQPNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQDEDVPDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMNDLMRPALYDAYHHIEAVEPKNIAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAGAYGASMASNYNARNRAAEVLVDGNEYRLIRRRETLEQQMANELACL
What is the function of this protein?
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
What are the official names of this protein?
Diaminopimelate decarboxylase, DAP decarboxylase, DAPDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Protein: MMM1_SCHPO
Sequence: MIHLPQGSFTQGLIVGQLLTLAIIYVFLRFFLFCSPIPKSVANSPKQTGNETPDETPSTPLSNNKKRYKKPLTILEPHILNLLYDVNEHEPESLDWFNVLIAQALIQFRYDACSNDVALRKLETVLNKGAQDKSMVDHIYVRDLSLGDGFPVFSHCRVLPHQHNSSQLRAEMLVSLTDNINCTVDTKLLLNFPKPAFATLPLSITVRICKFVGKIMIYFSPSNGAGQPAYMNLSFDPNFVISLQVSSLVGARSKLQDIPKITQLIESRIRQWFTNRCVSPQFQQIAIPNLWPTSAKEGHARSHAPQEESSNED
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: MZT1_DANRE
Sequence: MASPASANMNAVRETMDVLLEISRLLNTGLDMESLSICVRLCEQGINPEALSSVIKELRRASDSLKASENSTSQG
What is the function of this protein?
Required for gamma-tubulin complex recruitment to the centrosome.
What are the official names of this protein?
Mitotic-spindle organizing protein 1, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1.
What is the protein family that this protein belongs to?
Belongs to the MOZART1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Protein: PPD7_ARATH
Sequence: MSLKPYFSLLYSSPTNVKLSNFLIAQQPSGDLKTTPAEEFSPLVEKFNRRLLLGVGSSSVLAIGANFGGTTSFILGLSPGIGRNLKLDVIYPIGGYSRCIDTVEGFEFIYPATWVGDQTLLYRAAEKSERENSLDLPPARNSRRKNVNEPVVAFGPPGSTGELNVSVIVSPVSPSFSIEAFGGPKEVGEAIVRTVTGSGQRADLKGTLLESSIRQDSERNLKYYELEFKVESPLFRRHNVAVCCAHSGRLYTLNAQAPESAWSEVKSEIYTTAKSFNIIS
What are the official names of this protein?
PsbP domain-containing protein 7, chloroplastic, Photosystem II reaction center PsbP family protein.
What is the protein family that this protein belongs to?
Belongs to the psbP family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IPL1_ASHGO
Sequence: MDADAILKKDQRRSSLKQRNLLLSMRLNQTTATNGAPPQARVQPGKGYRNPGKVLSPIRNQEMSPGKRPTLEISELKNVSPINQAHKTGKARAGGVPLSKLQNLKLADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKRKTLCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVGSPPFEEESKELTYKRILKRNLIFPDHVDTEARHLISRLLEYDPGDRIPLKEVKKHPWIEKNKPFW
What is the function of this protein?
Required for high-fidelity chromosome segregation during the later part of each cell cycle.  Acts in opposition to the phosphatase PP1.  Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles.  The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension.  Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity).
What are the official names of this protein?
Spindle assembly checkpoint kinase, Aurora kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and on elongated and disassembling spindles. Also associated with the kinetochore (By similarity).
Protein: G6PI_ECOL5
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCRA_STAA8
Sequence: MNALLNHMNTEQSEAVKTTEGPLLIMAGAGSGKTRVLTHRIAYLLDEKDVSPYNVLAITFTNKAAREMKERVQKLVGDQAEVIWMSTFHSMCVRILRRDADRIGIERNFTIIDPTDQKSVIKDVLKNENIDSKKFEPRMFIGAISNLKNELKTPADAQKEATDYHSQMVATVYSGYQRQLSRNEALDFDDLIMTTINLFERVPEVLEYYQNKFQYIHVDEYQDTNKAQYTLVKLLASKFKNLCVVGDSDQSIYGWRGADIQNILSFEKDYPEANTIFLEQNYRSTKTILNAANEVIKNNSERKPKGLWTANTNGEKIHYYEAMTERDEAEFVIREIMKHQRNGKKYQDMAILYRTNAQSRVLEETFMKSNMPYTMVGGQKFYDRKEIKDLLSYLRIIANSNDDISLQRIINVPKRGVGPSSVEKVQNYALQNNISMFDALGEADFIGLSKKVTQECLNFYELIQSLIKEQEFLEIHEIVDEVLQKSGYREMLERENTLESRSRLENIDEFMSVPKDYEENTPLEEQSLINFLTDLSLVADIDEADTENGVTLMTMHSAKGLEFPIVFIMGMEESLFPHIRAIKSEDDHEMQEERRICYVAITRAEEVLYITHATSRMLFGRPQSNMPSRFLKEIPESLLENHSSGKRQTIQPKAKPFAKRGFSQRTTSTKKQVLSSDWNVGDKVMHKAWGEGMVSNVNEKNGSIELDIIFKSQGPKRLLAQFAPIEKKED
What is the function of this protein?
Essential helicase.  May act as a helicase in plasmid pT181 replication.
What are the official names of this protein?
ATP-dependent DNA helicase PcrA, DNA 3'-5' helicase PcrA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: RPIA_VIBVY
Sequence: MTQDEMKKAAGWAALKYVEKGSIVGVGTGSTVNHFIDALGTMSEEIKGAVSSSVASTEKLEALGIKIFDCNEVASLDIYVDGADEINADREMIKGGGAALTREKIVAAIADKFICIVDGTKAVDVLGTFPLPVEVIPMARSYVARQLVKLGGDPCYREGVITDNGNVILDVYGMKITNPKQLEDQINAIPGVVTVGLFAHRGADVVITGTPEGAKIEE
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: MTNC_YERPP
Sequence: MIQAIVTDIEGTTTDIRFVHQVLFPYARERLTPFLRAHQQDDDIAALLVDLRREIAQPDADIETLITVLHGFMDEDRKSTVLKAIQGIIWRTGYLQADFRGHVYPEVAQQLADWHQQGLKLYVYSSGSVAAQKLLFGYSDAGDLCPLFSGYFDTHVGAKRDVSAYQKIANQLGIAPQALLFLSDIRQELDAAQLAGWHTCQLIRDLPDNDSAHPQVNRFDQIVLSLFTE
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.