PharMolix/UniProtQA huggingface dataset:
Protein: ALBA_IGNH4
Sequence: MAAQIPQSNEVRVGKKPVMNYVLATLTLLNQGVDRIEIKARGRAISKAVDTVEIVRNRFLPGQVRVAEIRIGSQTVTSADGRQSRISTIDIVLERVK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: NEP_I60A0
Sequence: MDPNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ACCD_LACCB
Sequence: MSQPQLTQEALAREAALPENLWIQCPYCKQGSYRESLGNAQVCPHCHYGFRITAKKRLSLIATATEEWDADLVTADPLDFPGYTEKLAAGQAATGLKDSVWTGQATIGGQSCALGIMDPKFMMGSLGTVTGERLTRLFEKATSANLAVVLFCASGGARMQEGIHSLMQMAKVSAAVKAHSNAGLLFISVLTDPTMGGVTASFAMQGDITLAEPHSLIGFAGRRVIEQTINQKLPQNFQRAETLLQSGFIDAVVQRQDQPSYLGDLLALHTA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_CHLCH
Sequence: MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGELVDFMSSGACVPMILEKENAVADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSVENAAIEAAFFFSTEEVVRSN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_SALHS
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: AIM14_LACTC
Sequence: MAMTLLPRHGKTHLANIPYGYYTATVSLIFIILLIGARKLIPVRQRNRSKWAKWALSSARGGSPLLYLVVLFVALLVPFVHHYSLLGYVGLYLKRLGRLSYVLATLNLFLTLRPNFLLPGYVYLDLIPLHKWLSRSLCLLALVHGVGFLVKWALDSQVSFVAKAFYNIPNLAGLVVGALMAFMVLLSVRPVRRFSYRSFYLTHIIGAWVFVFLTAYHARPGVFVPYTLLNAGLFVFYILSKTVPARGVELVSKSTDDVNNCLTRIVLPRKAMPEHFAPGSHLRISPYRRVNPLYYMLPSHPYTVASMPEDKDVELIVREHASGFHLLTGLGYTIQNHYESVPRQCLQSATRIALVCGGSGLSYALPIFRHFASEEKADQVKYLRLIWLVRDKYDVNVLGNIRSLASSVAQFDIFVTRSVPPDDTVESGSKLSPAQQQSPITDDLEFELESFGDQLDQNGALITPEIPNLPSGLASSFHFGRKLDWMTDLAQFVEREDLGSTWLVACGPKGLNDAAKLYAQQNEINLASETYAL
What is the function of this protein?
Probable cell surface metalloreductase.  May be involved in iron or copper homeostasis (By similarity).
What are the official names of this protein?
Probable metalloreductase AIM14.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family. AIM14 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TOLR_SHIFL
Sequence: MARARGRGRRDLKSEINIVPLLDVLLVLLLIFMATAPIITQSVEVDLPDATESQAVSSNDNPPVIVEVSGIGQYTVVVEKDRLERLPPEQVVAEVSSRFKANPKTVFLIGGAKDVPYDEIIKALNLLHSAGVKSVGLMTQPI
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
What are the official names of this protein?
Tol-Pal system protein TolR.
What is the protein family that this protein belongs to?
Belongs to the ExbD/TolR family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LOLA_KLEP3
Sequence: MKKLAITCALLSGMVVSQVWADAASDLKSRLDKVSSFHASFTQKVTDGSGNAVQDGQGDLWVKRPNLFNWHMTQPDESVLVSDGKTLWFYNPFVEQATATWLKDATSNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKSGSGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDASKFTFTPPKGVTVDDQRK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EFP_NITEC
Sequence: MKTAQELRVGNVFMLGRDPMVVLKTEFTKSGRNSSVVKMKYKNLLTESPGEAVYKADDKFDIVVLEKKEVSYSYYASPMYVFMDAEFNQYEVEEETMSDVLSFLEDGMPCEVVFYNDKPISVEMPNSVVREIIYTEPAVKGDTSGKVMKSAKIVTGFELPVPLFCEIGDKIEIDTRTREYRSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_ACTPJ
Sequence: MNIWQSTSIITWLLAPFSLLFWLVSQIRLFLFRKKILKSYRSPVPVLVVGNISVGGNGKTPVVVWLVEQLQQRGVKVGVISRGYGGKSKDFPQLVTNQSSAEMVGDEPVLIVQRTGVPLAISANRQQSIELLLNQFKLDLIVTDDGLQHYALQRDIEWVVVDGIRRFGNGFVLPAGGLRELPSRLQSVQAIICNGGKAQPNEHLMTLEPEFAVNLRTGEQKPITDFIGQECVAIAGIGHPPRFFNMLENLGVKLLKTQGFADHQAFEPAQLKALAAEQIPLLMTEKDAVKCRTFAQQNWWYVPVSAKFSPESTACLLEPILKRLGK
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: KPSE_ECOL6
Sequence: MLIKVKSAVSWMRARLSAISLADIQKHLAKIIILAPMAVLLIYLAIFSQPRYMSESKVAIKRSDDLNSGSLNFGLLLGASNPSSAEDALYLKEYINSPDMLAALDKQLNFREAFSHSGLDFLNHLSKDETAEGFLKYYKDRINVSYDDKTGLLNIQTQGFSPEFALKFNQTVLKESERFINEMSHRIARDQLAFAETEMEKARQRLDASKAELLSYQDNNNVLDPQAQAQAASTLVNTLMGQKIQMEADLRNLLTYLREDAPQVVSARNAIQSLQAQIDEEKSKITAPQGDKLNRMAVDFEEIKSKVEFNTELYKLTLTSIEKTRVEAARKLKVLSVISSPQLPQESSFPNIPYLIACWLLVCCLLFGTLKLLLAVIEDHRD
What is the function of this protein?
Involved in the translocation of the polysialic acid capsule.
What are the official names of this protein?
Capsule polysaccharide export inner-membrane protein KpsE.
What is the protein family that this protein belongs to?
Belongs to the BexC/CtrB/KpsE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DSP2_ORYSJ
Sequence: MQLEISPRQRSQQQKEEEGEHQQRAGEEAVGAVFSIEPWVDAAAVLVPPLNFAEVNDGIFRSGFPAADNFAFLLSLKLRSIVYLCPEPYPEENTRFLEQNGIKLHQFGIDGSKELLVNIPEEKIREALKVILDVRNQPVLIHCKRGKHRTGCVVGCLRKLQKWCLTSVFDEYQHFAAAKARSTDQRFMELFDTSSLMHLTASQC
What is the function of this protein?
Probable tyrosine-protein phosphatase that acts as negative regulator of defense responses against the fungal pathogen Magnaporthe oryzae.
What are the official names of this protein?
Probable tyrosine-protein phosphatase DSP2, Protein PLANT AND FUNGI ATYPICAL DUAL-SPECIFICITY PHOSPHATASE 2, OsPFA-DSP2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SIA4B_HUMAN
Sequence: MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
What is the function of this protein?
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697).  Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169).  Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697).  Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity).  Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity).  Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912).  Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169).
What are the official names of this protein?
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2, Alpha 2,3-ST 2, Beta-galactoside alpha-2,3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, Monosialoganglioside sialyltransferase, ST3Gal II, ST3GalII, ST3GalA.2, Sialyltransferase 4B, SIAT4-B.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
Protein: COQ10_SCHPO
Sequence: MAFRCTLRRLECYRASRLMPYKPSFLFSLISNVNEYERFVPFCQKSKVTEYDPKTGYPTKADLTVGFKGLCETFDSKVVCDPVALTVLADASHHRLFRRLKTHWSIEEASRGRVRVDLEVDFEFASKLHGMMSKFVGSSVASEIIQGFVQQAKIKHKLESENEK
What is the function of this protein?
Required for the function of coenzyme Q in the respiratory chain.  May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
What are the official names of this protein?
Coenzyme Q-binding protein coq10, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: Y3749_YERPE
Sequence: MFRWGIIFLIIALIEAALGFGGLAGTAAWAAKVVFVVGIILFLISLFTGRKRL
What are the official names of this protein?
UPF0391 membrane protein YPO0432/y3747/YP_3749.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F151A_MOUSE
Sequence: MSCKKWCSSSQAKWILAGSVTVTLVLAISLILGLTLHQGTQPGCENDAICGPDADMLDYLMGMGQISHRDGLLVTWYHAANSKKEMAAALNSDVMVLEADVTVEGFNTANETKVPIMAHPPAIYSDNTLQEWLEAVLASSQKGIKLDFKSLKAVGPSLDLLRQLTEAGRIRRPVWINADILRGPNVPISIEINATQFLTLVQEKYPKATISPGFTTLYVPQLPNSTYTQAMVETMQELVGALPQKVTFPVRAVMTRAAWPHFSWLLSQSERYSLTLWQGASDPVSVEDLLFIRDNSAAHQIYYDLFEPVLSQFKQLALNTTRKRTYYTGGSLIPLLQQPKGDGLEVEWLVLEVNGSGRRAAITVPDREGMILLDIGLQEPEAGNPVPILHTPGGPALTLESCLLRLAVHPRRWGIHVNIVEPEALRPSLATLAHLSTLGHLPWPVWVGSTVSHGSFVVPGHIAGRELLTAVAEVFPHVTVAPGWPEEMLDSGYQEQMVTDMLELCQGLRQPVSFQLQAGPLSQSPANTVARLLASSPRATVTVYHSTAGNSHVDLWAGLWAARAVDRTRVYYRISQEYWKDLQADVSSNRPSSRIGPSSVEGFPGESR
What are the official names of this protein?
Protein FAM151A.
What is the protein family that this protein belongs to?
Belongs to the FAM151 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y219_RICPR
Sequence: MKENFNVSKLKNGLTILTYNMPYVHSVAINLIAKVGARYENEEEEGISHFLEHMAFKGTKTRTAQQIAEEFDSIGGYFNAYTGHENTVYYARVLSENCHKALNILADIIQNSIFADEEIAKEYQIIMQEIAHHHDNPDDLIYETFYNTVYKGQPLGKSILGTTKTLVTFTKEHFLNFIGKHYNAENLYLSIAGNIEHNKIVMIAEELFASLKQGVKSSFIPAKYIGGKGFIHKELEQTSLVLGFECTSYINLGQLYQTYLLSIIFGGGMSSRLFQSIREKLGLAYVVGSYNSAYFDSGVFTIYASTAHNKLELLYREIKNEIIKITETVSTEEIIRAKMQLRSNLQMAQEQNTYKSEEIGKNYSVFGKYILPEEIIEIITNIRADDIINTANKIFSGTTTLAIIGPNDLNGF
What are the official names of this protein?
Uncharacterized zinc protease RP219.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
Protein: DPYD_DICDI
Sequence: MTGHTGDVSQVHDIEILALNPTVNKHATFKPTIVSKKDKENWARLDHCKKGCELKNDFEDVKPTTLTERGALFESARCLKCADAPCQKGCPTQLDIKSFISSISTKNYYGAAKTIFSDNPLGLTCGMVCPVSSLCQYGCNLAATEEGPINIGGLQQFATEVFKKMNIPQIRDPSLTPLSQLPESYKAKIALIGCGPTSISCATFLGRLGYTDVTIFEKEQYLGGLSSSEIPNYRLNYEVVEFEIKLMKDLGVKVEYGKRLGENGFTVESLQKQGYEAIYLGIGMPEPKIDPVFNELTSDQGFFSSKEFLPKVSKASKAGMCGCKSQLPQLNGRVIVLGAGDTAFDCATSAFRCGASRVTVCFRRGFSDMRAVPEEVDIAKDERCEFLPYVLPKQVIKRDGKVVAMEFYKTEKGDDGNYSVDEDQFFRVKCDYIISAFGSQIGSVAESCSPLQFNKWGTADIDPMTMTSKHAEWLFCGGDLVGNGTTVEAVNDGKTASWNIHKYLQSLHGIPIPDGPPQLPNFFTPIDLVDISVEMCGMKFPNPFGLASATPATSAAMIRRSFEQGWGFAVTKTFSLDKDLVTNVSPRIVRGTTSGHHFGPGQGAFLNIELISEKTCHYWCKAIGELKRDFPDRIVIASIMCGFNKEDWTQLAKMAEASGADGIELNLSCPHGMGEKGMGLACGQDTELVFHICQWVRAATRLPFFAKLTPNVTEIKEIAKAAHDGGADGVTAINTVSGLMGLKGDSNAWPAIGDEKRTTYGGVSGNATRPIALRAVSSIRKSLPDYPIMATGGADSADATIQFLHCGASVVQICSSVQNQDFTVVQDYITGLKTYLYMQSREDLLQWDGQSPPNEIINKNPKLKGLPKFGKYLLERNRIDTEEKQNIDLQKVKNPLVPSPNPTHPVPSLKDQINRAIPRIGRHDDLKRDQQVVALIDEDKCINCGKCYMTCNDSGYQAIKFDGKTHIPLVTDLCTGCDLCLSVCPVPDCITMVPRETIYVPDRGLTVQN
What is the function of this protein?
Involved in pyrimidine base degradation.  Catalyzes the reduction of uracil and thymine (By similarity).
What are the official names of this protein?
Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the dihydropyrimidine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B4GT1_MOUSE
Sequence: MRFREQFLGGSAAMPGATLQRACRLLVAVCALHLGVTLVYYLSGRDLSRLPQLVGVSSTLQGGTNGAAASKQPPGEQRPRGARPPPPLGVSPKPRPGLDSSPGAASGPGLKSNLSSLPVPTTTGLLSLPACPEESPLLVGPMLIDFNIAVDLELLAKKNPEIKTGGRYSPKDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGDTMFNRAKLLNIGFQEALKDYDYNCFVFSDVDLIPMDDRNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLAINGFPNNYWGWGGEDDDIFNRLVHKGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMRFDGLNSLTYKVLDVQRYPLYTQITVDIGTPR
What is the function of this protein?
The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.  The secreted form is responsible for the synthesis of complex-type to N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
What are the official names of this protein?
Beta-1,4-galactosyltransferase 1, Beta-1,4-GalTase 1, Beta4Gal-T1, b4Gal-T1, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Lactose synthase A protein, N-acetyllactosamine synthase, Nal synthase, Neolactotriaosylceramide beta-1,4-galactosyltransferase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
[Isoform Long]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Cell projection, filopodium. Note=Found in trans cisternae of Golgi. B4GALT1 cell surface expression is regulated by UBE2Q1 (PubMed:18511602). SUBCELLULAR LOCATION: [Isoform Short]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi. SUBCELLULAR LOCATION: [Processed beta-1,4-galactosyltransferase 1]: Secreted. Note=Soluble form found in body fluids.
Protein: BDS3A_BUNGR
Sequence: MSAQRFLFLLVVTSLIAASLAAPKDVQLTKRGTPCWCGKTVGIYWFALYSCPGGHGYTGHCGQFMGVCCYPADP
What is the function of this protein?
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG.  Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels.
What are the official names of this protein?
U-actitoxin-Bgr3a, U-AITX-Bgr3a, U-AITX-Bg1b.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: CHRR_PSEPU
Sequence: MSQVYSVAVVVGSLRKESYNRKVARALSELAPSSLALKIVEIGDLPLYNEDVEAEAPPEAWKRFREEIRRSDAVLFVTPEHNRSVPGCLKNAIDVGSRPYGQSAWSGKPTAVVSVSPGAIGGFGANHAVRQSLVFLDMPCMQMPEAYIGGAASLFDDSGKLNDKTRPFLQAFVDKFASWVKLNRAV
What is the function of this protein?
Catalyzes the reduction of quinones.  Acts by simultaneous two-electron transfer, avoiding formation of highly reactive semiquinone intermediates and producing quinols that promote tolerance of H(2)O(2).  Quinone reduction is probably the primary biological role of ChrR (By similarity).  Can also reduce toxic chromate to insoluble and less toxic Cr(3+).  Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen.  This reaction produces transiently a minimal amount of the toxic Cr(5+) species and reactive oxygen species (ROS).  Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity (By similarity) (PubMed:10788340).
What are the official names of this protein?
Quinone reductase, Chromate reductase, CHRR, NAD(P)H dehydrogenase (quinone).
What is the protein family that this protein belongs to?
Belongs to the SsuE family.
Protein: BATF_RAT
Sequence: MPHSSDSSDSSFSRSPPPGKQDSSDDVRKVQRREKNRIAAQKSRQRQTQKADTLHLESEDLEKQNAALRKEIKQLTEELKYFTSVLSSHEPLCSVLASGTPSPPEVVYSAHAFHQPHISSPRFQP
What is the function of this protein?
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.  Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'.  The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes.  Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B).  Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF.  In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)).  Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation.  Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1.  Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
What are the official names of this protein?
Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor, B-ATF.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells.
Protein: RNFH_ECO81
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSHPAKLSDIVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.