PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_BACAA
Sequence: MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSMKDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASYKELAEGAILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEEDYDAIILATAGLQRMGWDNEVITEHLDETLCVPAVGQGALAIECREDDKDLLQLLAHINDAVTEKTVAAERVFLHKLEGGCQVPIAGYATITENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKELILAANKGQQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: DHG_GLUOX
Sequence: MSTTSRPGLWALITAAVFALCGAILTVGGAWVAAIGGPLYYVILGLALLATAFLSFRRNPAALYLFAVVVFGTVIWELTVVGLDIWALIPRSDIVIILGIWLLLPFVSRQIGGTRTTVLPLAGAVGVAVLALFASLFTDPHDISGDLPTQIANASPADPDNVPASEWHAYGRTQAGDRWSPLNQINASNVSNLKVAWHIHTKDMMNSNDPGEATNEATPIEFNNTLYMCSLHQKLFAVDGATGNVKWVYDPKLQINPGFQHLTCRGVSFHETPANATDSDGNPAPTDCAKRIILPVNDGRLVEVDADTGKTCSGFGNNGEIDLRVPNQPYTTPGQYEPTSPPVITDKLIIANSAITDNGSVKQASGATQAFDVYTGKRVWVFDASNPDPNQLPDDSHPVFHPNSPNSWIVSSYDRNLNLVYIPMGVGTPDQWGGDRTKDSERFAPGIVALNADTGKLAWFYQTVHHDLWDMDVPSQPSLVDVTQKDGTLVPAIYAPTKTGDIFVLDRRTGKEIVPAPETPVPQGAAPGDHTSPTQPMSQLTLRPKNPLNDSDIWGGTIFDQMFCSIYFHTLRYEGPFTPPSLKGSLIFPGDLGMFEWGGLAVDPQRQVAFANPISLPFVSQLVPRGPGNPLWPEKDAKGTGGETGLQHNYGIPYAVNLHPFLDPVLLPFGIKMPCRTPPWGYVAGIDLKTNKVVWQHRNGTLRDSMYGSSLPIPLPPIKIGVPSLGGPLSTAGNLGFLTASMDYYIRAYNLTTGKVLWQDRLPAGAQATPITYAINGKQYIVTYAGGHNSFPTRMGDDIIAYALPDQK
What are the official names of this protein?
Quinoprotein glucose dehydrogenase, Glucose dehydrogenase [pyrroloquinoline-quinone].
What is the protein family that this protein belongs to?
Belongs to the bacterial PQQ dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Periplasmic side.
Protein: RNH_SHIB3
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_BACCN
Sequence: MLNIGPFTFKSRLLLGTGKFSDYDVQRKAIEVSEAEILTFAVRRMDIFDAQQPNLLEKIDIKNYTLLPNTAGAKTAEEAVRIAKLAKASGLCDMVKVEVIGDDKTLLPDPVETLKASEMLLEEGFIVLPYTSDDVVLARKLQELGVHAIMPGASPIGSGLGIVNPLNISFIIEQATVPVIVDAGVGSPADAAFAMELGADGVLLNTAVSGAKDPIKMAEAMKLGIHAGRLGFEAGRIARKRFATASSPLEGMSVVE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_YERPP
Sequence: MIEADRLISAAVINDEESIDRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDALDHVLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVADLEHIVSRSAKCLGLELTPEGAHQLARRSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRKLLLAVIDKFMGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRIATNHAYKHFGITREE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: GAP50_PLAF7
Sequence: MNYCKTTFHIFFFVLFFITIYEIKCQLRFASLGDWGKDTKGQILNAKYFKQFIKNERVTFIVSPGSNFIDGVKGLNDPAWKNLYEDVYSEEKGDMYMPFFTVLGTRDWTGNYNAQLLKGQGIYIEKNGETSIEKDADATNYPKWIMPNYWYHYFTHFTVSSGPSIVKTGHKDLAAAFIFIDTWVLSSNFPYKKIHEKAWNDLKSQLSVAKKIADFIIVVGDQPIYSSGYSRGSSYLAYYLLPLLKDAEVDLYISGHDNNMEVIEDNDMAHITCGSGSMSQGKSGMKNSKSLFFSSDIGFCVHELSNNGIVTKFVSSKKGEVIYTHKLNIKKKKTLDKVNALQHFAALPNVELTDVPSSGPMGNKDTFVRVVGTIGILIGSVIVFIGASSFLSKNMK
What is the function of this protein?
Component of the glideosome complex, an inner membrane complex structure involved in parasite gliding motility and host cell invasion (PubMed:16321976, PubMed:16513191, PubMed:16750579, PubMed:19576251).  During the asexual blood stage, may play a role in the assembly and anchoring of the glideosome complex to the inner membrane complex (PubMed:16750579).  During the sexual stage in the vector mosquito midgut, protects gametocytes against host alternative complement pathway-mediated elimination by interacting with host complement inhibitor factor H (PubMed:23332154).  Has phosphatase activity towards nucleotides such as ATP, vitamins B1 and B6, phosphorylated sugars, glycerol phosphates and inositol triphosphates (PubMed:20070315).  However, the phosphatase activity is controversial (PubMed:22387043).
What are the official names of this protein?
Glideosome-associated protein 50, PfGAP50, Secreted acid phosphatase, PfSAP.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Protein: SNMP1_DROER
Sequence: MQVPRLKLLMGSGAMFVFAIIYGWVIFPKILKFMISKQVTLKPGTDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPRLQEVGPFVFDEWKDKYDLEDDVVEDTVSFNMRNTFIFNPKETLPLTGEEEIILPHPIMQPGGISVQREKAAMMELVSKGLSIVFPDAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEVKQAKQVNQTHFLFSFMGQANHSDAGRFTVCRGVKNNKKLGKVVKFADETEQDIWPDGECNTFMGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDMGDIRADEKLHCFCEDPEDLDTCPPKGTMNLAACVGGPLMASMPHFYLADPKLIADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMEPVEGIEPMKNLPKLIMPMFWVEEGVHLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDITSILKENNKVDDVTSTKEPLPPTNPKQSTTVHPVQVPNTLIPGTNPATNPATHLKMEHRERY
What is the function of this protein?
Plays an olfactory role that is not restricted to pheromone sensitivity.
What are the official names of this protein?
Sensory neuron membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPA_CHLPM
Sequence: MSNQDLKGSAVALVTPFREDFSIDTDALKQLVHFHAEAGTDIIIPCGTTGESPTLNPEEQADIIRIVRDEAKGKMLVAAGAGTNSTRSAVTLAKNAEDAGAEAILSVAPYYSKPSQEGIYQHYRHIAEAVSVPIIIYNVPGRTGCNVSAETILRLAGDFSNIAAVKEASDNFTQIADLLDGRPEHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAAVKQLVDSAAAGNLEEARRISRTYRNLFRLNFIESNPAPIKCALAMMGMIKEVYRLPMTPVSEESRRQLSLEMSALGLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN_WHEAT
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CYH2_BOVIN
Sequence: MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGAQAPSPPSLPGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
What is the function of this protein?
Acts as a guanine-nucleotide exchange factor (GEF).  Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6.  Promotes the activation of ARF factors through replacement of GDP with GTP.  The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity).  Involved in neurite growth (By similarity).
What are the official names of this protein?
Cytohesin-2, PH, SEC7 and coiled-coil domain-containing protein 2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection. Cell projection, growth cone. Note=Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane. In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas.
Protein: Y569_NEIG1
Sequence: MNLSNHFLVAMPDMEDAFFSQSVVYICKHDEDGALGIAINKPSPITMDMIFSATGKNIPMRMQHDSVMMGGPVQVERGYVVHTPIGNWQSSIGVSDGIALTSSRDVLENISREGAVDKALISIGYSSWSKGQLERELADNAWLTVPADEHILFDIPYEHRYAAAFAKLGIDPLALFSGAGHA
What are the official names of this protein?
UPF0301 protein NGO0569.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RSMF_SHESA
Sequence: MVQLNQNFINTIAQELPAHLSMDDFIAACSRPLRRSIRVNTLKTSSEDFKRLMQPKGWTFEPIPWCEDGFWISYDEEEQLGNALEHIQGLFYIQEASSMLPPTALFTPNADWQCVLDLASAPGSKTTQMAALMNNQGLLVANEYSASRVKVLHANVLRMGASHCALTHFDGRVFGEYLYESFDAVLIDAPCGGEGTVRKDADALKSWSLDEVIEISETQKALIESAFLALKPGGSLVYSTCTLNRHENQGVCEYLQQTYGDAVQFESLSQLFDGAEKATTPEGFLHVWPQIYDSEGFFVAKLTKTRSVPRLQPEPKLQKNFPFTEASAKQAKAIQAYFADDLGIELPDDLIMVRDDEFWLFPHEFRDFIGKMRFQRIGVKLADHSKHGFKVRHEAIIALAGKALKAGAKNGAKVVEVSDEQAKEYLMGRDIPLDTAGKAQGEVIVCYGGAPLGMAKHLGNKLKNSLPRDLVKDKVLLLPPQA
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y658_TRIL1
Sequence: MTIWIDADACPRVIKEIVFRASERLNLPVMLVANKPLAKHHAGLISSVVVDDGPDVADDYIAEQATAQDLVITADIPLAARIVAKGAVGIDPRGELYNEDNVGERLSMRDLMQSLRSEGLVQGGPAQFGMTDRQRFASSLDRVLTRMMREAKKQ
What are the official names of this protein?
UPF0178 protein Glov_0658.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RCAN1_HUMAN
Sequence: MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS
What is the function of this protein?
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556).  Could play a role during central nervous system development (By similarity).
What are the official names of this protein?
Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1.
What is the protein family that this protein belongs to?
Belongs to the RCAN family.
Protein: CH60_ACIET
Sequence: MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASKTNDIAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVVALVEELKKASKATTTSKEIAQVGSISANSDESVGKIIADAMDKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINNPEKQSAILDNPFVLLFDKKISNIRDLLPTLEQVAKASRPLLIIAEEVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAKRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALLRAKQAVGNLSTGNPEQDAGIKLVLKAVEAPLREIVANAGGEPSVVVNEVLNGKGNYGFNAANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDESAAPAMPGGMGGMGDMGM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_BARBK
Sequence: MDNIIDGKKLAENVIAKVKNETEKLKNSHNIQPGIAVIIVGDDPASQVYVASKSKKAEECGFFSMKHVLPKEVEESELLQLIEILNSDPKIHGILVQLPLPAHINTDRATQAIAVEKDVDGFHYINIGKLAANAIKDAIIPCTPAGAMMMIEQQCGQDLSGLNAVIVGRSNIVGKPMAALLTAANATVTLAHSRTRDLDEICRRADILIAAVGRPQMIKKHWVKKGAIVIDVGINRIAAPEKGPGKTRLVGDVDFEEVKGKTLAITPVPGGVGPMTIAMLMVNTLKAAARSLKLPVPKF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: WTF35_SCHKA
Sequence: MKNNYTSLKSPLDEEDELKTDHEIDLEKGLLPEYNSEEEGALPPYSDISKLAKTVPEDSSTGPTETANPNVERRQGFKDSHPNIYSLLRLLISVLAVSVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPILFIAIFCFFETWTQAVAQCIKVTAIFLAQCVKACGKGIKHFLKKWENMPMAFSEVFLFNILVGSPRMNLRYIFGDRWGLKCSLAEHITFVVLSILVFIAETVKPGSIRVNLIRKMGYEAKQQVNEYTAVPLREMNPESEA
What is the function of this protein?
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (PubMed:32032353).  Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity).  Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
What are the official names of this protein?
Meiotic drive suppressor wtf35.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: RELA_STRCO
Sequence: MPDEAQPLTAAKPESASASAAKPAPSAPQAKNDTHGPIQHAPAAPVDKPAEQQPRPKPLPAERPQNAPVVRAPAGQPARSGSSNRVRARLARLGVQRANPYNPVLEPLLRIVRGNDPKIETSTLRQIERAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLEDLRRDFGDVVTLLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAVVTDEVQQDLRAARIKATVTGRPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPGGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVAGASKVRTDAPKSSGKSKDDHLNDMAWLRQLLDWQKETEDPGEFLESLRFDLSRNEVFVFTPKGDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIVRAMRKQNLPIQRILTGDSLVTLAHEMRYSDISALYAAIGEGHVSAPNIVQKLVQALGGEEAATEEIDESVPPSRGRGRKRRANADPGVVVKGVEDVWVKLARCCTPVPGDPIIGFVTRGSGVSVHRSDCVNVDSLSREPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTSARRPS
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp.  PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions.
What are the official names of this protein?
GTP pyrophosphokinase, (p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: IHOG_DROVI
Sequence: MSLTRRFSLTLLLLLPLLTSLLAAIPVLQANLSPAPSSSPGPGVRILRAPESTVAPPGDEVVFVCETSLPPEYFEWSYASSRSHPPRFKYLKSSSAKANHNITITHNNDISKLRVIVRPETLGEYRCVAWFGPLAVTSTTARLEMASISGDGADTDQRAHWRVAAGNTVLWHCGQVASNPAPSWSFYYNDNEMPPASTLSDSNGTLLLPHVSAASSGSYSCVATNTASGVRLALPSRLELQVPAAALASTAPALLNGQRVRTQVFAKAGETVLLLCPGVGYPPPTAVWSSPNVPGAVYNNRTRVLPYGLQISALQPLDAGTYICYLDNGIRPALEHFIELVVQKSPRILRPPTANLTNEGERMQLECEATGMPKPEIYWLLNGESSVYDVEAEQVPNGHLILHSVQKRHAGYVQCFARNSLGEHSAGTLLQVNPKQLPDGEGTGMDSGRSSARPTHSRKQKQQTQMVPPSAPNVTRLSDESVMLRWHVVRNDGLPIQFFKVQYRMLTESGKRKSWQTTNENIPYGRQRHESGAGVRNFTSSVTGLKPNSSYRFRIMAVYSNNDNKESNTSGKFFLQRGAALAPLAVPELVDIEEYSQTAVVLHWRLSSDADEQLISGYYAYYRPSASAGEYLKATIDGAKSRSFQISALEPGTIYEFKLQSFSAVAASEFSALKQGRTQRPRASSTPQPVLHAVDTTTPSHNETFNMNPMLTGTIGGGALLVLLVISACLCLCRRRSSRGNNPQHKPRLAELREDFVPLNTCSPNKPRTRHIHITLNPLAQQQQQQQQQQLQQQQHDEKEAQDNDMGYFQRQPVVYDAETLGFNGLARMSSSSLRRSQRTLERAAAGGGSGGNNNNLNQPGDGSLANSADSPRLQASNKPGRVILKRARLSSRSENLSSGSLNSVGV
What is the function of this protein?
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
What are the official names of this protein?
Interference hedgehog.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. IHOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: UGPE_BRUA2
Sequence: MIEQRPVSNLIGHLILILGIIIVAFPIYYTFVASSMTSTQIIRPPISLLPGDHLVENYREAIFGGVERVVGVSLERLLWNSFVVAMAIAVGKIIISFMSAFAIVFFRFPMRMFFFWMIFITLMLPVEVRILPTYKVIVDLGMIDTYAGLTLPLMASATATFLFRQFFLTIPGELVEAARIDNAGPFRFMRDILLPLSKTNIAALFVILFIYGWTQYLWPLLVTNDAKMNTIIIGLRRMVDWADASTPWNYVMVTAILAIIPLILVVVLMQRWFVKGLVETEK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CDPF1_DROME
Sequence: MDPDDDLVLENEAEEIERLQLPEELKKPIDPEEEDERVARIEFNCSGCEMHEMVHYFGRKPPFALGVIYPEDNYVMRDPFQPPPPRWQSKPEYYIAMGTKCSICSKTVCKDPGCSFYYTASFCLPCGKEELKNWPPEAQARIRKQMSVSQGRQT
What are the official names of this protein?
Cysteine-rich DPF motif domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDPF1 family.
Protein: DAPD_ESCF3
Sequence: MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEIVEGVIVEEGSVISMGVYIGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBD_PONPY
Sequence: MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQVQAAYQKVVAGVANALAHKYH
What are the official names of this protein?
Hemoglobin subunit delta, Delta-globin, Hemoglobin delta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LT_POVWU
Sequence: MDKTLSRNEAKELMQLLGLDMTCWGNLPLMRTKYLSKCKEFHPDKGGNEEKMKKLNSLYLKLQECVSTVHQLNEEEDEVWSSSQIPTYGTPDWDYWWSQFNSYWEEELRCNEEMPKSPGETPTKRTREDDEEPQCSQATPPKKKKDNATDASLSFPKELEEFVSQAVFSNRTLTAFVIHTTKEKAETLYKKLLSKFKCNFASRHSYYNTALVFILTPFRHRVSAVNNFCKGYCTISFLFCKGVNNAYGLYSRMTRDPFTLCEENIPGGLKENDFKAEDLYGEFKDQLNWKALSEFALELGIDDVYLLLGLYLQLSIKVEECEKCNSNEDATHNRLHMEHQKNALLFSDSKSQKNVCQQAIDVVIAKRRVDSLNMSREDLLARRFEKILDKMDKTIKGEQDVLLYMAGVAWYLGLNGKIDELVYRYLKVIVENVPKKRYWVFKGPINSGKTTVAAALLDLCGGKALNINIPADRLNFELGVAIDQFTVVFEDVKGQVGDNKLLPSGNGMSNLDNLRDYLDGSVKVNLEKKHLNKRSQIFPPGIVTMNEYLVPATLAPRFHKTVLFTPKRHLKESLDKTPELMVKRVLQSGMCILLMLIWCRPVSDFHPCIQAKVVYWKELLDKYIGLTEFADMQMNVTNGCNILEKHNA
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.