PharMolix/UniProtQA huggingface dataset:
Protein: RIP1_MYCLE
Sequence: MMFALGIVLFAIAILISVALHECGHLWVACATGMKVRRYFVGFGPTLWSTRRGETQYGIKAVPLGGFCDIVGMTSVEKLEPDESDRAMYKQATWKRVAVLFAGPAMNFVICLVLIYGIALVWGLPNLHMPTRAVIGETACVASELDQGKLGNCTGPGPAALAGLRAGDVVVKIGDTTVSTFDDMAAVVRKLHGTVPIVFERDGTAITSYVDITPTQRYMSKGKGSQLEPATVGAIGVGAHHLLPTHYGVFSALPATAAFAGDLTVEVGKALVTIPTKLGALVHAIGGGQRDPQTPMSVVGASIIGGDTVDHGLWVAFWFFLAQLNLILGAINLVPLLPFDGGHIAIAVFERIRNLIRSARGVVVAAPVNYLKLMPATYVVLVFVVGYVLLTVTADLVNPIRLFQ
What is the function of this protein?
A probable intramembrane site-2 protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains.  Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal (possibly oxidative stress) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this entry), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein.
What are the official names of this protein?
Zinc metalloprotease Rip1, S2P endopeptidase, Site-2 protease Rip1, S2P protease Rip1, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SQS1_PANGI
Sequence: MGSLGAILKHPEDFYPLLKLKFAARHAEKQIPPEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSIPTEVKVPILMAFHRHIYDKDWHFSCGTKEYKVLMDEFHHVSNAFLELGSGYQEAIEDITMRMGAGMAKFICKEVETINDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKTCKESGTLSKRKSYIIESESGHNSALIAIIFIILAILYAYLSSNLLLNKQ
What is the function of this protein?
Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:15356323, PubMed:27746309, PubMed:29378087).  Catalyzes the biosynthesis of squalene (PubMed:15356323).
What are the official names of this protein?
Squalene synthase 1, PgSS, PgSS1, PgssA, SQS 1, SQS 4, FPP:FPP farnesyltransferase SS1, Farnesyl-diphosphate farnesyltransferase SS1.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KAE1B_METJA
Sequence: MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAFEVVDKNEIDLIAFSQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQFARYVNLPHPGGPYIEELARKGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALAHTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMSLDETKIIPNYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDKAVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction (By similarity).  The Bud32 domain probably displays kinase activity that regulates Kae1 function.  In vitro, exhibits low ATPase activity, but does not bind DNA and does not have endonuclease activity.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAEHP_METBF
Sequence: MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPSTLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFIHPDAQDYNKIYRYNYGATKLAIKRALGGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFDNPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISRIREVRPDAFIVADLKTLDTGNLEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRGIDIEATEHAWGNIAEIKKIAPKILVAVAGGVRLDKVPVALGQGADILVVGRAITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
What is the function of this protein?
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
What are the official names of this protein?
Bifunctional enzyme Fae/Hps.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
Protein: RS3_MICLC
Sequence: MGQKINPNGFRLGITTDHVSHWFADSHKEGQRYADFLKEDVKIRELMTTGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGELEKLTGKQIQLNILEVKNPETDAQLVAQGVAEQLASRVAFRRAMKKAIQSAMRAGAQGIRIQCSGRLGGAEMSRSEFYREGRVPLHTLRANIDFGKFEAKTTFGRIGVKVWIYKGDLTAKELAAKEAAQPSGRGRGGERRGGGERRRRNDRAERAPRQENAGAGAETPAAAPAEGGNA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TBL1X_MOUSE
Sequence: MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
What is the function of this protein?
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units.  Plays an essential role in transcription activation mediated by nuclear receptors.  Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).
What are the official names of this protein?
F-box-like/WD repeat-containing protein TBL1X, Transducin beta-like protein 1X.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EBI family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalized with MECP2 to the heterochromatin foci.
Protein: RAB6A_MOUSE
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC
What is the function of this protein?
Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).  Has a low GTPase activity.  Involved in COPI-independent retrograde transport from the Golgi to the ER.  Recruits VPS13B isoform 2 to the Golgi membrane.  Plays a role in neuron projection development.
What are the official names of this protein?
Ras-related protein Rab-6A, Rab-6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Note=BICD2 facilitates its targeting to Golgi apparatus membrane.
Protein: K1C40_BOVIN
Sequence: MASDCSPTGCSSESSARASDCALASTCSVETTCLPSACATSSCQTPSFPSGARLPTGCLPPACFAGSCNIPCVVGNCAWCEDGVFNSNEKETMQFLNDRLASYLEKVRGLEELNAELECRIREQCEEDVPLVCPDYQCYFDTIEDLQQKILCTKAENCRLAVQLDNCKLAADDFRSKYESELSLRQLVETDISGLRGILGELTVCRSDLEAHVESLKDDLLCLKKSHEEEVNVLRGQLGDRLSVELDTAPTTDLNRVLDEMRCQYETVLANNRRDVEEWFAAQTEELNQQQLSSAEQLQGCQTEILELKRTANTLEIELQAQQSLTESLECTVAETEAQYSSELAQIQCLIDNVENQLAEIRCDLERQNQEYRVLLDTKARLECEINTYQGLLDSEDSRLPCNPCSATSMSNDTCEPCSAYVICTVENSCP
What is the function of this protein?
May play a role in late hair differentiation.
What are the official names of this protein?
Keratin, type I cytoskeletal 40, Cytokeratin-40, CK-40, Keratin-40, K40.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: KPRS_STAAN
Sequence: MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF137_ARATH
Sequence: MKKYFQPSFVILIIFTVLVLGVVGNMSVDQKRCWATLKENNCVHDECRSMCLKKNPKGHGRCIKSSKGRIICLCGYDCP
What are the official names of this protein?
Putative defensin-like protein 137, Putative low-molecular-weight cysteine-rich protein 14, Protein LCR14.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIOXL_ARATH
Sequence: MEKVNQTFFLSHGSPTLSIDDSLEARQFFKSWTQKVLPQKPKSILVISAHWDTKFPSVNTVLRNNTIHDFSGFPDPMYKLKYEAPGAIELGKRVKELLMKEGGMKRVDEDTKRGLDHGAWVPLMLMYPEADIPICQLSVQSNQNGSYHYNMGKALASLKDEGVLIIGSGSATHNLRKLDFNITDGSPVPWALEFDHWLRDSLLQGRYGDVNEWEEKAPNAKMAHPWPEHLYPLHVVMGAAGGDAKAEQIHTSWQLGTLSYSSYSFTSSL
What is the function of this protein?
Opens the cyclic ring of caffealdehyde between carbons 2 and 3 or between carbons 4 and 5.  Involved in the biosynthesis of arabidopyrones.
What are the official names of this protein?
Extradiol ring-cleavage dioxygenase, AtLigB.
What is the protein family that this protein belongs to?
Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.
Protein: SODC_DROSI
Sequence: MVVKAVCVINGDAKGTVFFEQESSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQGGHELSKSTGNAGARIGCGVIGIAKV
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn], Superoxide dismutase 1.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JHBP_PLAVG
Sequence: ETLFDPCSTQDIKKVGV
What is the function of this protein?
Prevents juvenile hormone from being hydrolyzed by general esterases by combining with it specifically.
What are the official names of this protein?
Juvenile hormone-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: HYPB_AZOVI
Sequence: MCTVCGCAEGETRIEGEHHHHGHDHHHHEHPFVRRPAPAEAAPPAAGGPNLHFGQGPARAHAPGLSQSRMLRIEQDILGKNDRYAAENRARFEALSLFVLNLVSSPGSGKTSLLTRTIELLGRRRPLAVIEGDQQTDHDAARIRATGVPAVQINTGKGCHLDAHMVGHALARLDDLEGGLLFIENVGNLVCPAAFDLGEAHKVAILSVTEGEDKPLKYPDMFHAADLMLLNKTDLLPHLDFDVEACIAYARRVNPDIEVIRVSARSGEGMGEWLAWIERQRGTRLRARIDALREQARALEALL
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.  Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion.
What are the official names of this protein?
Hydrogenase maturation factor HypB.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
Protein: GSA_OPITP
Sequence: MSVSDSLFERAKQLMPGGVNSPVRAFRSVGGAPFFVKAARGATLVTADDQELIDFVCTWGPAIHGHNHPRIKAAIAEALEHGTSFGTPNPYEVEMAELIVRFFPSIQKVRMCNSGTEATMSAIRLARGFTKRSKIIKFAGCYHGHSDSLLIKAGSGALTHGHPDSAGVPISFAQETVVVTYNDRAALEAAFAANVGQIACVIIEPYCGNVGFIMPDAGYLQAVRELCTREGAVLIFDEVMTGFRQARGGVQELENITPDLTCLGKIIGGGLPVGAFGGRTYLMDLLAPLGPVYQAGTLSGNPLAMAAGIAALKLLDEENPYARLDQLGRQLRDAVLAAAKTKGLPVQVPQRGSMFSIFFTPQPVRDYASALAGDAKLFGRFFHTCLANGVYLAPSAYEAAFLSTAHEGAAIDRACEVLASAINEL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_BORPA
Sequence: MTQVFQKVSAIRGMNDVLPGPSARWEKFEEIVRGWLRSYGYRNVRTPVLEHTRLFARGIGEVTDIVEKEMYTFTDALNGDSLTMRPEMTAGIVRASIEHNMLYDRPHRVYAIGPVFRHERPQRGRYRQFHQIDVEALGFAGPDVDAEMIVMLARLWKLLGLQDVRLELNSLGQPAERAAHRAALIEHLERHQDILDEDGRRRMYSNPLRVLDTKNPAMQEMADSAPRLFDFLGEESRSHFDGLCQRLADAGIEYRLNPRLVRGLDYYNLTVFEWVTDRLGAQGTVCGGGRYDGLVELLGGKPAPAVGFAIGMERLLDLWEQSVEIEQPAECEVYIVHQGEEGQRLAARVGEQLRDAGLDVIVHAGAAGFKAQFKRADASGARIAVILGGDEVASRTASIKHLRGPVGADAAQQQVPLAQLADVLKSKG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_PELPB
Sequence: MAKESYKRDKPHVNIGTIGHVDHGKTTLTAAITSVLAKQGLAAARDFGSIDKAPEERERGITISTAHVEYQTKKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAGTDGPMPQTREHILLARQVNVPSLVVFLNKVDIADPELIELVELELRELLTQYNFPGDDIPIVKGSALKALEGDPEGEKAIMELMDAVDSFIPDPVRDIDKPFLMPVEDVFSISGRGTVGTGRIERGRIKINEEVEIVGLRPTRKSVVTGIEMFQKLLDEGQAGDNAGLLLRGVDKTELERGMVIAKPGTIKPHTKFKAEVYILKKEEGGRHTPFFNGYRPQFYFRTTDVTGSVTLPEGVEMVMPGDNLGVEVELLAPIAMDEGLRFAIREGGRTVGAGSVTTIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_COXBU
Sequence: MYCPFCNAEDTKVIDSRLVEEGTQVRRRRECLKCQERFTTFETAELNLPRIIKRDGRRSAFDEEKLRAGLLKALEKRPISTEQIETAVQRIIHKLRARGECEVSSQWLGELVMDELRALDEVAYVRFASVYRSFQDINAFRDEIRRLQKQQKKSHDK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RF3_STAAC
Sequence: MNLKQEVESRKTFAIISHPDAGKTTLTEKLLYFSGAIREAGTVKGKKTGKFATSDWMKVEQERGISVTSSVMQFDYDDYKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIETYPMNWPIGMGQSFFGIIDRKSKTIEPFRDEENILHLNDDFELEEDHAITNDSDFEQAIEELMLVEEAGEAFDNDALLSGDLTPVFFGSALANFGVQNFLNAYVDFAPMPNARQTKEDVEVSPFDDSFSGFIFKIQANMDPKHRDRIAFMRVVSGAFERGMDVTLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGKQTYSFQDLPQFTPEIFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMKNEYNVDVVMEPVGRKIARWIENEDQITDKMNTSRSILVKDRYDDLVFLFENEFATRWFEEKFPEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).
What are the official names of this protein?
Peptide chain release factor 3, RF-3, RF3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_RHIWR
Sequence: MNIHEYQAKELLAKFGVAVPAGHAALTVDEAVEAAKKLPGPIWVVKAQIHAGGRGKGKFKELPADAKGGVRLSKSIDEVKANAADMLGNTLVTIQTGEAGKQVNRLYVTDGADIKSEYYLSMLVDRKTGRIAMIVSTEGGMDIEQVAHDTPEKIRTIVIDPAEGFQPHHGRAVAFALKLKGDLNKQAVKLAEQLYNAFIATDMSMLEVNPLVETTDGKLLVLDAKVSFDSNALYRHPDILALRDETEEDPAEIEASQYDLAYIKLDGDIGCMVNGAGLAMATMDIIKLNGMFPANFLDVGGGATKEKVTAAFKIILSDPAVKGILVNIFGGIMRCDIIAEGIIAAAKEVNLSVPLVVRLEGTNVQQGKDLLAGSGLPIVAADDLGDAARKIVAEVKKAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: ATPI_PELHO
Sequence: MNILSCSINTFKELLYDISGVEVGQHFYWQIGGFQVHGQVLITSWVVIAILLGSSILAVRNPQTIPTDVQNFFEYVLEFIRDVSKTQIGEEYGPWVPFIGTLFLFIFVSNWSGALFPWKIIQLPQGELAAPTNDINTTVALALLTSVAYFYAGLTKKGLAYFNKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLLSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DNAA_BACCR
Sequence: MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFIIPQSQAEEDIDLPPVKPNPAQDDSAHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINGILK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_CHLAD
Sequence: MKEFFRLSRKGFTGRDDVDSAQIPDDLWVKCSACRELIYKKQLNDNLKVCPKCGHHMRMSAHEWIGLLDVGSFREMDSNLLPTDPLGFVAADESYATKLAKTQQRTGMTDAVISGVGAISGIRLCIAVADFSFMGASMGSVYGEKMARAAERAAELGIPLLTINTSGGARQQEGVIGLMQMAKITMALTRLAEAGQPHIALLVDPCYGGVTASYPSVADIIIAEPGANIGFAGKRLIEQIMRQKLPAGFQTAEFMLEHGMIDMVVPRSEMRETLARILKHYQQRQAPAAKADLAARRATLPQPIM
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNAI3_RAT
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
What is the function of this protein?
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:2159473).  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins.  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels.  Stimulates the activity of receptor-regulated K(+) channels.  The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  May play a role in cell division.
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-3, G(i) alpha-3.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Protein: RL1_BLOPB
Sequence: MTGKLSKRMRMMRDCADTSIQYPVLDGLELLKKMARVKFVESVDTAINLGIDARKSDQNIRNNVILPHGIGRDIHVAVFTQGDNIVLAKNAGADLVGLEDLYDQIKNKNYRPDVVIASPDVMNVVSKLGPILGPRGLMPNLKMGTVSHDIAESVKNVKSGQIRYKNDKSGIIHATIGKINFDLIQLKENLEALIVSLKQAKPILYKGTYIKKVTISTTMGRSISIDRNSLCVVIN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: TAM_ECO45
Sequence: MSDWNPSLYLHFAAERSRPAVELLARVSLENIEYIADLGCGPGNSTALLHQRWPAARITGIDSSPAMIAEARSALPDCLFVEADIRNWQPEQALDLIFANASLQWLPDHYELFPHLVSLLSPLGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQHFLTRYHQMLEEQYPLQENGQILLAFPRLFIVARRTE
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.