PharMolix/UniProtQA huggingface dataset:
Protein: JIP5_PODAN
Sequence: MLENLCTLPLSADLFTQVLHPSEPLLTVGLASGKVETFRLPNDDDEEDESGRRTSTSSGRGMIKSIWSTRRHKGSCRHLAYSHDGSAMYSAGTDSVVKHFSPETGNVISKIGLPPRNSATSTTDCPAILHVLSPQTLLLGTDSGGLYIFDLRENGSLNPKPVRKHVPHADYISSITPLPASAESTSGFPKQWVSTGGTTLAVTDLRHGIVATSEDQEDELLCSTIIPTGLGPKKMRSNAVVAVGTGNGILTLWDRGAWDDQQERINVAGGRTKKDGESLDAIVRVPDELGWGKKVIVGVGDGSLSIVDLKRREVQFVLKHDEVEGVSALTFDYQNRLISGGGRTVKVWAESGDDDLDEEEEEEAEATGFKRPARSDSDSDDDSEDERPQKSSNKKQKKGKGNQARSVAFPGLD
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RGYR1_AERPE
Sequence: MASARAASRGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKGDFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGVELVRTALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVYRLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEISDLALLLNIEHPIKHRSRAEGNTQGNTWVSNFVACAVKSPEVSRVWGAGVG
What is the function of this protein?
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process.  It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue.  May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
What are the official names of this protein?
Reverse gyrase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
Protein: SNX25_MOUSE
Sequence: MDRVLRDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWEIVKQIRQRLSHVDVVKVVCNDIVKALLTHFCDLKAATARHEEQPRPFVLHACLKDSHDEVRFLQTCSQVLVLCLLPSKDIQSLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLRQLEYREQMSEHHKRAYTYAPSYEDFIKLINSNSDVDFLKQLRYQIVVEIIQATTISSFPQLKRHKGKESAAMKTDLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGASDEGEGPQSQKILQFEDIMTNPFYRERFGTYMERIDKRALVGFWESAEHLKNANKSEIPQLVSEMYQNFFVESKEISVEKSLYKEIQQCLVGNRGIEVFSKIQADVSEVLRERYYPSFLVSDLYEKLMREEEEEEPDAQLASEKDELGSGGEAGEEAVEGTSGVSDPASFAVIKLRELNEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKECTALQLHMARTDWWCENLGLWRASITSAEVTEENGEQMPCYFVRVNLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGKSRNQLNAFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFLEKLPRDFFSHQEEEIEEDSDLSDYGDDVDGKKDSLAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWISSEQMLVYYISAFRDAFWPNGKLAPPTRIRSVAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETKANKHLLYVLMELLLTELCPELRAHLDQFKAGQV
What is the function of this protein?
May be involved in several stages of intracellular trafficking.
What are the official names of this protein?
Sorting nexin-25.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein.
Protein: CALYP_DROME
Sequence: MNAAGGGSGAQAAAVAAGNNSLSHNALLSTASGATTMPMAQLADGWLELESDPGLFTLLLKDFGCHDVQVEEVYDLQKPIESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHGGWEDSEDWTDKFRRVMAERLGIATGEQDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTLQKLLKADEQGESGNGDSQRPDTPTTLLEPSAFTARDLQSLLKNLDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKVSGQGAANRISKQSTTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRRRKGRNKCRKRK
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1).  Does not deubiquitinate monoubiquitinated histone H2B.  Required to maintain the transcriptionally repressive state of homeotic genes throughout development.  The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase calypso, BAP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family. BAP1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to PcG response elements (PREs).
Protein: S61A1_ONCMY
Sequence: MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLLNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSTRFSGNFLVNLLGTWSDTSTGGPARAYPVGGLCYFLSPPESFGSVLDDPIHAAIYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMGGHRETSMVHELNRYIPTAAAFGGLCIGGLSVMADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEMGSMGALLF
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides.  May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins.  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.
What are the official names of this protein?
Protein transport protein Sec61 subunit alpha isoform A.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Protein: RDL2_ARATH
Sequence: MAATPIRVIVSALVILSVLLLSSSLGVATETEIERNETEVRLMYEQWLVENRKNYNGLGEKERRFKIFKDNLKFVDEHNSVPDRTFEVGLTRFADLTNEEFRAIYLRKKMERTKDSVKTERYLYKEGDVLPDEVDWRANGAVVSVKDQGNCGSCWAFSAVGAVEGINQITTGELISLSEQELVDCDRGFVNAGCDGGIMNYAFEFIMKNGGIETDQDYPYNANDLGLCNADKNNNTRVVTIDGYEDVPRDDEKSLKKAVAHQPVSVAIEASSQAFQLYKSGVMTGTCGISLDHGVVVVGYGSTSGEDYWIIRNSWGLNWGDSGYVKLQRNIDDPFGKCGIAMMPSYPTKSSFPSSFDLLSEI
What is the function of this protein?
Probable thiol protease.
What are the official names of this protein?
Probable cysteine protease RDL2, Probable cysteine proteinase At3g19400, RD21A-like protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: TONB_CAMCO
Sequence: MKTFISNHKNQSSFITLFVFTPLFFVFLYSKDFLHIQPNETIKENKFNMAIKHFVQNSSDMKPTQPTQTIQEPSNVQPKEPVQEIKKIKPRKEKLIAKPKKIIPPANAKAISQPKKDTNMQQPIMQQQTPQASSYQSVALTSNSEFLKEIKSAIDEALIYPRQARKMRMSGEVLVEFTWTKEKKLENLKILKPSKYDFLNKSALETIRIASKKFPQYEKTFHIKIPLVYKLS
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: GUTR_BACSU
Sequence: MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDKIALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEATTIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTEQPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCVDDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALANYTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQLSGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMALSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSKPPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSEQHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQWASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSGWALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETILNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYFNLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESNQKAIRLIDSWEPAIGIRGEVERLARATKENE
What is the function of this protein?
Activator of the glucitol dehydrogenase gene (gutB).
What are the official names of this protein?
Transcription activator GutR.
Protein: LIPA_LEPIC
Sequence: MNPLKKKPRTHSLQNAPEKPDWLKVKLAFPDPKNNPVAIVRNSLEEKKLNTVCESASCPNLNHCWSRKTATYMLGGDICTRRCSYCDVASGKPFPLDPEEPKRIAESSIALGLRHVVITSVNRDDLEDGGAAHFAKTVKEIRKGLPDCKIELLIPDLKVKQEALEIIFECNPDIFNHNLETVKRLFPEVAPQKRYERSLDVLKIASARGFLTKSGLILGMGETLEEVKECMQDLASVGVSLLTLGQYLQPTSTHLPVKEYVVPQVFKDLRIYGKSIGFKGVFSGPLVRSSYHADEQISWNP
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPIII_ASPOR
Sequence: MHMLLFIGALALPVFVCTQSCEPASLSPRLAGVDLEKFRLTPNAEYVDSDQQIPISTTNVGLIEQSYVETAIKLVRETFPNATFRLREDHYVGDNGVAHVHFRQTVHNLDVDNGDFNVNVGRDGSVFSYGNSFYTGPVPSITQLTKRDFTDPVAALKFALTHLQLPITAEDVSVESTKHPHKYVLRGTSGAVTNPKARLVYFVKPDGTLCLVWRVETDVDDNWLLTYVDAKTAEEIHGVVDYVSEATFQVYGWGINDPGQVDSRAVLTDPWDLKESPLTWFRDGQKNWTTTRGNNGIAQENINNLPTYLNNFRPDSPTQNFSYEYPAGGSPKDYINASITQLFYTANAYHDLLYTLGFNEKAGNFQWNNSGLGGKEKDYVILNAQDGASRNNADFATPPDGSPARMRMYLFTHTTPPRDGVFESGIVIHEYTHGLSMRLTGGPDNSRCLSAFESASMGEGWGDFMATAIRLKPSDTRATDYGMGMWVYNNEKGIRQYLYSTSMETNPLNYTSLNRMWEAHAGGTVWASMLYEVLWNLIDRHGKNDGPRPTFDERGVPKDGKYLAMKIVIDAMALQPCNPDFVQARNAILDADQALTGGQNKCEIWTGFAKRGLGQGAEYGRGRRVGSYDIPGDVCQKKI
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Extracellular metalloproteinase NpIII, Elastinolytic metalloproteinase NpIII, Fungalysin NpIII, Neutral protease III.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: AQP4_NOTAL
Sequence: MSDGAGAAARRWGKCGGRSCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPNVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYTEVEDNRSQVETEDLILKPGVVHVIDIDRGEDKKGKDSAGEVLSSV
What is the function of this protein?
Forms a water-specific channel.  Plays an important role in brain water homeostasis and in glymphatic solute transport.  Required for a normal rate of water exchange across the blood brain interface.  Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways.  Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP.  Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
What are the official names of this protein?
Aquaporin-4, AQP-4.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-183 and promotes its internalization from the cell membrane (By similarity). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (By similarity).
Protein: RIBB_CHLT3
Sequence: MNPLLEKKFGDEFTRVENALTALRSGKGILVSDSPDRENEADLIFSAEFLTETQMAMLIRECSGIVCLCLTTEKVQALALPMMVSENTSGFQTAFTVSIEAKTGVKTGVSAADRVRTVKTAIAADAKPEELARPGHVFPLRARTGGVLERPGHTEATVDLMRLAGLSPYGVLCELTNPDGTMANLDEAIAFAEKHDFPVLTVEDVINYRLEKEREKSASPALFSVFEN
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: GCH4_PSEU2
Sequence: MNKPLPDVALTEISPALVSLDWVGMQGVEVPIRLAEASIRHPVHAHVDLQVDLADPSVKGIHMSRLYRLLDGYAERQIVSPDTLAALLEAMVESHLDCHSSHARLTLSFNLLCRRPALITEGLSGWKSYPVKLDATWHAGRLCLDSSVDITYSSTCPCSAALSRQLLEEAFAARFGRQSFVDPMQVATWLRENASFATPHSQRSVATVQVRVAEQAAELGLMTLIDLVEQALGTPVQTAVKRADEQAFARLNGQNLMYVEDAARKVQQALEGRYAASSVSVRHFESLHPHDAAAQTSNYLS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RL31_PHOLL
Sequence: MKKGIHPKYEEITATCSCGSVIQVRSTAGHALNLDVCGQCHPFYTGKQRDVATGGRVDRFKKRFNVPGVSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RL13_PSEPW
Sequence: MKTFTAKPETVKREWFVVDAAGQTLGRLATEIASRLRGKHKPEYTPHVDTGDYIVVINAEQIRVTGAKSSDKMYYSHSGFPGGIKEINFEKLIAKAPERVIETAVKGMLPKNPLGRDMYRKLKVYAGAAHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: AROB_CAMC5
Sequence: MQIRLNLEQKKYGYNVYINELERIEIKGKTAIVTNPKIAGLHLNTLLNSLKCDEYFIISVPDGEEYKNLATIELILEQLFTSKLDRSSTLIAFGGGVISDMTGFAASIYERGINFINIPTTLLAQVDASVGGKTGVNNKFGKNMIGSFYQPKAVYCESKFLRTLAFREFNAGLAEAVKMAVTFDKEMFEWLENVTLDEEQNLAKLVERSVLIKARVVEADEKERGLRALLNYGHTFAHVIENETGYKKYLHGEAVAIGMNMANSLSVKLGLMSEKDALRIKELLAKFSLPTHYVLRDESAFYEAFMLDKKTQEGSVKFILSNGIGSAVMKNDIKRDDVIKILREFK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_PSESM
Sequence: MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLESYDIQGWAGTVSVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLVAAPEGIAAVERAHPDVMIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: DMRTC_HUMAN
Sequence: MAAPPKAPIRVRNLTIRAGALTGKENNMLQPETHIFTAPEEGSSQGALLLGQAPEPLSLPCTPVTLEQQLVSPSGDPHRAPALPSICSTLILQPCATLDPLLLQPQVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGDKGFQPPSPSLRPRPASSISLPIGHLGCISLLS
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor C1.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
Protein: TRBE_ECOLI
Sequence: MMKVIFTSNRFIDFLIRLLITAIVISPVIIWSWDTVKETTADGMLAAAFVILYSGVLLFILYFCFSALTDLQKPDERKSDERNEDE
What is the function of this protein?
Not determined yet.  Not required for conjugation transfer in rich, aerobic growth media.
What are the official names of this protein?
Protein TrbE.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LRX3_ARATH
Sequence: MKKTIQILLFFFFLINLTNALSISSDGGVLSDNEVRHIQRRQLLEFAERSVKITVDPSLNFENPRLRNAYIALQAWKQAILSDPNNFTSNWIGSNVCNYTGVFCSPALDNRKIRTVAGIDLNHADIAGYLPEELGLLSDLALFHVNSNRFCGTVPHRFNRLKLLFELDLSNNRFAGKFPTVVLQLPSLKFLDLRFNEFEGTVPKELFSKDLDAIFINHNRFRFELPENFGDSPVSVIVLANNRFHGCVPSSLVEMKNLNEIIFMNNGLNSCLPSDIGRLKNVTVFDVSFNELVGPLPESVGEMVSVEQLNVAHNMLSGKIPASICQLPKLENFTYSYNFFTGEAPVCLRLPEFDDRRNCLPGRPAQRSPGQCKAFLSRPPVNCGSFSCGRSVSPRPPVVTPLPPPSLPSPPPPAPIFSTPPTLTSPPPPSPPPPVYSPPPPPPPPPPVYSPPPPPPPPPPPPVYSPPPPPPPPPPPPPVYSPPPPSPPPPPPPVYSPPPPPPPPPPPPVYSPPPPPVYSSPPPPPSPAPTPVYCTRPPPPPPHSPPPPQFSPPPPEPYYYSSPPPPHSSPPPHSPPPPHSPPPPIYPYLSPPPPPTPVSSPPPTPVYSPPPPPPCIEPPPPPPCIEYSPPPPPPVVHYSSPPPPPVYYSSPPPPPVYYSSPPPPPPVHYSSPPPPEVHYHSPPPSPVHYSSPPPPPSAPCEESPPPAPVVHHSPPPPMVHHSPPPPVIHQSPPPPSPEYEGPLPPVIGVSYASPPPPPFY
What is the function of this protein?
Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization.
What are the official names of this protein?
Leucine-rich repeat extensin-like protein 3, AtLRX3, LRR/EXTENSIN3, Cell wall hydroxyproline-rich glycoprotein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ACE2_HYPJE
Sequence: MDLRQACDRCHDKKLRCPRISGSPCCSRCAKANVACVFSPPSRPFRPHEPLNHSHEHSHSHSHNHNGVGVSFDWLDLMSLEQQQEQQQGQPQHPPPPVQTLSERLAALLCALDRMLQAVPSSLDMHHVSRQQLREYADTVGTGFDLQSTLDSLLHHAQDLASLYSEAVPASFNKRTTAAEADALCAVPDCVHQDRTSLHTTPLPKLDHALLNLVMACHIRLLDVMDTLAEHGRMCAFMVATLPPDYDPKFAVPEIRVGTFVAPTDTAASMLLSVVVELQTVLVARVKDLVAMVDQVKDDARAAREAKVVRLQCGILLERAESTLGEWSRFKDGLVSARLLK
What is the function of this protein?
Positive regulation of the major cellulase and xylanase genes (cbh1, cbh2, egl2 and xyn2).  Binds to the 5'-GGCTAATAA-3' site present in the cbh1 promoter.
What are the official names of this protein?
Transcription factor ACEII.
What are the subcellular locations of this protein?
Nucleus.
Protein: SKDA1_HUMAN
Sequence: MGDLKSGFEEVDGVRLGYLIIKGKQMFALSQVFTDLLKNIPRTTVHKRMDHLKVKKHHCDLEELRKLKAINSIAFHAAKCTLISREDVEALYTSCKTERVLKTKRRRVGRALATKAPPPERAAAASPRPGFWKDKHQLWRGLSGAARPLPISAQSQRPGAAAARPAAHLPQIFSKYPGSHYPEIVRSPCKPPLNYETAPLQGNYVAFPSDPAYFRSLLCSKHPAAAAAAAAAAAAAAAAAAAAAYYQVSAAGPQPKAAAGAGGPGSLSYRCKRKRGGAKDCLLAPHAGARRLLLLPRSYKAKAAAAAAAAAAAAAAAAGATCLERFHLVNGFCPPPHHHHHHHHHHHHHHHRAQPPQQSHHPPHHHRPQPHLGSFPESCSSDSESSSYSDHAANDSDFGSSLSSSSNSVSSEEEEEEGEEEEEEEEEEGGSGASDSSEVSSEEEDSSTESDSSSGSSQVSVQSIRFRRTSFCKPPSVQAQANFLYHLASAAAATKPAAFEDAGRLPDLKSSVKAESPAEWNLQSWAPKASPVYCPASLGSCFAEIRNDRVSEITFPHSEISNAVKRTDLTINCLAEGASSPSPKTNNAFPQQRILREARKCLQTTPTTHCADNNTIAARFLNNDSSGAEANSEKYSKILHCPEFATDLPSSQTDPEVNAAGAAATKAENPCTDTGDKTLPFLHNIKIKVEDSSANEEYEPHLFTNKLKCECNDTKGEFYSVTESKEEDALLTTAKEGFACPEKETPSLNPLAQSQGLSCTLGSPKPEDGEYKFGARVRKNYRTLVLGKRPVLQTPPVKPNLKSARSPRPTGKTETNEGTLDDFTVINRRKKVASNVASAVKRPFHFMANFPCPPSLIIGRDGDLWPAYSLNTTKDSQTPHKAHPIWKWQLGGSAIPLPPSHKFRKFNS
What are the official names of this protein?
SKI/DACH domain-containing protein 1, Protein DLN-1.
What is the protein family that this protein belongs to?
Belongs to the DACH/dachshund family.
Protein: CARA_ASHGO
Sequence: MTSDEAKKARFCLHGGPSYEGYSFGAPVSVGGEVVFTTSLVGYPDSMTDPSYKGQILVFTQPLIGNYGVPDGSVRDQYGLLKYMESSKVHVSAIVVAEYAWEYSHWTAVQSLGDWCRKEGVAAIGGIDTRAVVQYLRESGSTMGRVDVEGAAASARVVDPSKVNLVAQVSTKSPFYIPGKPSRVNYDVALVDCGVKENILRCLVVRGVNVTVFPYDYDVCSIAHHFDGVFISNGPGDPIHYRNSTVANLRRLLQDPDLQQVPIFGICMGHQLLALAAGASTVKMKYGNRAHNIPALDLSTGQCHITSQNHGYAVDAATLPRDEFVPLFVNLNDKSNEGIIHVSRPIYSTQFHPEGKGGPMDCSFLFDEYVERMRCYRKLFRQEPFIRFPVIGLPKARVL
What are the official names of this protein?
Carbamoyl-phosphate synthase arginine-specific small chain, CPS-A, Arginine-specific carbamoyl-phosphate synthetase, glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH2_RHOP5
Sequence: MADLWTNYLLPLLIVIGQSFLLLTVLLITIAYILLADRKIWAAVQIRRGPNVVGPWGLLQSFADLLKMVLKEPTIPSGANKGVFLLAPLVSCVLALAAWAVIPVDAGWMIADINVGVLYILAVSSLSVYGIIMAGWSSNSKYPFLAALRSAAQMVSYEVSIGFVIVCVLLCAGSLNLTAIVEAQNSQYGLLGWYWLPLFPVFVIFYVSALAETNRPPFDLVEAESELVAGFMVEYASTPYMLFVLGEYVAIATMCAMGAIMFLGGWLPPLPIAPFTWVPGVIWFTLKLFFMFFMFAMAKAIVPRYRYDQLMRLGWKVFLPLSLAMVVIVASVLQFAGLAPK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H 2, NADH dehydrogenase I subunit H 2, NDH-1 subunit H 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HCST_PIG
Sequence: MAPPGGILFLLLLPVAAAQVTSGSCSGCGPLSLPLLAGLVAADAVVSLLIVVGVFVCGRPRSRPTQEDGKIYINMPGRG
What is the function of this protein?
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation.  Functions as docking site for PI3-kinase PIK3R1 and GRB2.  Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways.  Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells.  In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors.  In T-cells, it provides primarily costimulation for TCR-induced signals.  KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).
What are the official names of this protein?
Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10.
What is the protein family that this protein belongs to?
Belongs to the DAP10 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.