PharMolix/UniProtQA huggingface dataset:
Protein: DCC_HUMAN
Sequence: MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF
What is the function of this protein?
Receptor for netrin required for axon guidance.  Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding.  Its association with UNC5 proteins may trigger signaling for axon repulsion.  It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.  Implicated as a tumor suppressor gene.
What are the official names of this protein?
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. DCC family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CYB_ASTOC
Sequence: MANLRKTHPLLKIANDALVDLPAPSNISVWWNFGSLLGLCLAAQILTGLFLAMHYTSDIATAFSSVAHICRDVNYGWLIRSMHANGASFFFICIYLHIGRGLYYGSYLYKETWNIGVILLLLVMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYIGNSLVQWIWGGFSVDNATLTRFFAFHFLFPFVIAAMTMIHLIFLHETGSTNPTGLNSDADKISFHPYFSYKDLLGFAILLIALITLALFSPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILILMLVPVLHTSKQRALTFRPFSQFLFWLLVANVAILTWIGGMPVEHPFIIIGQIASFLYFFIFLILVPTTGLLENKMLEWQ
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUP54_RAT
Sequence: MAFNFGAPSGTSGTSTATAAPAGGFGGFGTTTTTAGSAFSFSAPTNTGSTGLLGGTQNKGFGFGTGFGTSTGTGTGLGTGLGTGLGFGGFNTQQQQQQQQTSLGGLFSQPAQAPAQSNQLINTASALSAPTLLGDERDAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPNNKDEDGLVVLIFNKKETDIRSQQQQLVESLHKVLGGNQTLTVNVEGIKTLPDDQTEVVIYIVERSPNGTSRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPAQIKQLLQNPPAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQKNQTTTMAKIAQYKRKLMDLSHRTLQVLIKQEIQRKSGYAIQAEEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVKSEEKYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNETIHSRGGVFS
What is the function of this protein?
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
What are the official names of this protein?
Nuclear pore complex protein Nup54, 54 kDa nucleoporin, Nucleoporin Nup54.
What is the protein family that this protein belongs to?
Belongs to the NUP54 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.
Protein: CAS8A_METJA
Sequence: MIIKGLRVEKEKLQSLQKFWRLRVMLFETPGYNEILDLYIAYGVVECLVREGVENLRFFPIGNKYCIVVEEPTNVNIKNRIEKGMLNALEDMLSLHKAIGKYISTKEDIKIISDVDFSAGANINNVYWDGIPKTLEKIKENIKKGKLSTKSKNTVPLTLMPAAGKYMPKIYGVKGGNPIKIDDSNYALAWIGFHYYAPYINISDNRATYIHIYAIKPLEELGLIEILALKDLKKKINNYQLGKYKFFVNKKLALLYHLTHTESISALEIVTKKNFSVVSYTLENVDNNQAIRSFGEYDLSKLMDFLWYLKATDFYNTIQFVDNILRGDLEVSLTFIDGILYDDLDAVYSAIRKLKSVRISPLIIQSILEWFGNFY
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
CRISPR-associated protein Cas8a2/Csa4, CRISPR-associated protein Cas8a2/Csa4, subtype I-A/Apern.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas8a2/Csa4 family. Subtype I-A/Apern subfamily.
Protein: BCRH_RICPR
Sequence: MKIIAKIPAWMLLCLFILSPTTETIYTSGLPSLTRCFSIDGCITQMTSTLYFLGFAVGILSLGRLSDIYGRRPIVLLGLFIYIVSSIISIFSFNIEMLMIARFIQAFGVSVGSVIGQSMARDSYQGAELSYVYAILSPWLLFIPALGSYIGGYIIEYLSWHYVFIFFSLAGTILLALYYQILPETNYYIAFSQSSKYFEVFNIIIKDKMLWLYAFIIGAFNGIYYGFFIEAPFILIDQMRVLPSFYGKLAFLLSFASIFGGFLGGYLIKKRQVYDKKVMSIGFIFSLCGCILFAVDSFILEFILVSNVFAIAMIFMPMMIHMIGHSLLIAITLRYALEDYATVTGTAGSIFGAIYYVVIASVTYCVSKIHGETISNFSLLCLVLSISSVISFYYICLLYKKKSIIIN
What are the official names of this protein?
Uncharacterized transporter RP603.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Bcr/CmlA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMY1_ARATH
Sequence: MTSLHTLLFSSLLFFIVFPTFTFSSTLLFQSFNWESWKKEGGFYNSLHNSIDDIANAGITHLWLPPPSQSVAPEGYLPGKLYDLNSSKYGSEAELKSLIKALNQKGIKALADIVINHRTAERKDDKCGYCYFEGGTSDDRLDWDPSFVCRNDPKFPGTGNLDTGGDFDGAPDIDHLNPRVQKELSEWMNWLKTEIGFHGWRFDYVRGYASSITKLYVQNTSPDFAVGEKWDDMKYGGDGKLDYDQNEHRSGLKQWIEEAGGGVLTAFDFTTKGILQSAVKGELWRLKDSQGKPPGMIGIMPGNAVTFIDNHDTFRTWVFPSDKVLLGYVYILTHPGTPCIFYNHYIEWGLKESISKLVAIRNKNGIGSTSSVTIKAAEADLYLAMIDDKVIMKIGPKQDVGTLVPSNFALAYSGLDFAVWEKK
What is the function of this protein?
Possesses alpha-amylase activity in vitro, but seems not required for breakdown of transitory starch in leaves.
What are the official names of this protein?
Alpha-amylase 1, AtAMY1, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: ALDEC_PROMM
Sequence: MPTLEMPVAAVLDSTVGSSEALPDFTSDRYKDAYSRINAIVIEGEQEAHDNYIAIGTLLPDHVEELKRLAKMEMRHKKGFTACGKNLGVEADMDFAREFFAPLRDNFQTALGQGKTPTCLLIQALLIEAFAISAYHTYIPVSDPFARKITEGVVKDEYTHLNYGEAWLKANLESCREELLEANRENLPLIRRMLDQVAGDAAVLQMDKEDLIEDFLIAYQESLTEIGFNTREITRMAAAALVS
What is the function of this protein?
Catalyzes the decarbonylation of fatty aldehydes to alkanes.  Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity).  Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane.
What are the official names of this protein?
Aldehyde decarbonylase, AD, Fatty aldehyde decarbonylase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde decarbonylase family.
Protein: LIPB_ACTPJ
Sequence: MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPTNIPVVQTDRGGQITYHGEGQQVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYGIEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVNMDLTPFRNINPCGYAGLEMTQLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIMCSQYLPVKSKSSEL
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_ACIAD
Sequence: MPISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSESNHDLDLVTFKVIDQLSGRLLGVRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNFNSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLEGLHLDLGHVGLFRSLVKRAGLSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDASFKTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYDGIGEHFGRARPATGFSCDLYALCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQLLGNDDLSSVPYATHKMELAQDQWQINKI
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_BURVG
Sequence: MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDEQGADELTFLDITATSDQRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPQLVRDAADKYGSQCIVVAIDAKRVSAPNEAPRWEVFTHGGRKATGLDAIEWARKMAELGAGEILLTSMDRDGTKSGFDLALTRAVSDAVPVPVIASGGVGCLQDLADGIKQGHADAVLAASIFHYGEHTVGEAKHFMADQGIAVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOA_FINM2
Sequence: MPFEIPFLVPILIVILLLVFFSLVPVGLWVTAQFSGVHVKISQLIGMRLRRVIPKNIINPLIKATKAGLNLTTNQLEAHYLAGGNVNTLVNALIAAQRADIELEFERAAAIDLAGRNVLEAVQVSVNPKVIETPNIAAVAMNGIEVIVKAKVTVRANIERLIGGAGEETIIARVGEGIVTTVGSSESHTSVLENPDSISKTVLNKGLDSGTAFEILSIDIADVDVGRNIGAKLQTDQAEADKRIAQAKAEERRAMAVAKEQEMIAEVRSMRAKVVESESKVPLAIAKALESGNLGVLDYYNMKNIISDTEMRQAISGNSEKIKEDDK
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Membrane raft; Single-pass membrane protein.
Protein: RPIA_HAEIG
Sequence: MNQLEMKKLAAQAALQYVKADTIVGVGSGSTVNCFIEALGTIKDKIQGAVAASKESEELLRKQGIEVFNANDVSSLDIYVDGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDSSKQVDVLGSTFPLPVEVIPMARSQVGRKLVALGGSPEYREDVVTDNGNVILDVHNFSILNPVEMEKELNNVSGVVTNGIFALRGADVVIVGTPEGAKIID
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CARB_LACLM
Sequence: MPKRNDIKKIMIIGSGPIIIGQAAEFDYAGTQACLALKEEGYEVVLVNSNPATIMTDREIADTVYIEPITLEFVSKILRKERPDALLPTLGGQTGLNMAMELSKTGILEELNVELLGTKLSAIDQAEDRELFKELCESINEPLCASDIATTVEEAINIADKIGYPIIVRPAFTMGGTGGGICDTEEELREIVANGLKLSPVTQCLIEESIAGYKEIEYEVMRDSADNAIVVCNMENFDPVGVHTGDSIVFAPSQTLSDNEYQMLRDASLNIIRALKIEGGCNVQLALDPNSYEYRVIEVNPRVSRSSALASKATGYPIAKMSAKIAIGMTLDEIINPVTNKTYAMFEPALDYVVAKIARFPFDKFENGDRHLGTQMKATGEVMAIGRNIEESLLKAVRSLEIGVFHNEMTEAIEADDEKLYEKMVKTQDDRLFYVSEAIRRGIPIEEIADLTKIDIFFLDKLLYIVEIENQLKVNIFEPELLKTAKKNGFSDREIAKLWNVTPEEVRRRRQENKIIPVYKMVDTCAAEFESSTPYFYSTYEWENESKRSDKEKIIVLGSGPIRIGQGVEFDYATVHCVKAIQALGKEAIVINSNPETVSTDFSISDKLYFEPLTFEDVMNVIDLEEPLGVIVQFGGQTAINLAEPLSKAGVKILGTQVEDLDRAEDRDLFEKALQDLDIPQPPGATATNEEEAVANANKIGYPVLIRPSFVLGGRAMEIINNEKDLRDYMNRAVKASPEHPVLVDSYLQGQECEVDAICDGKEVLLPGIMEHIERAGVHSGDSMAVYPPQNLSQAIIDTIVDYTKRLAIGLNCIGMMNIQFVIYEEQVYVIEVNPRASRTVPFLSKVTNIPMAQLATQMILGENLKDLGYEAGLAPTPDMVHVKAPVFSFTKLAKVDSLLGPEMKSTGEAMGSDVTLEKALYKSFEAAKLHMADYGSVLFTVADEDKEETLALAKDFAEIGYSLVATAGTAAFLKENGLYVREVEKLAGGEDEEGTLVEDIRQGRVQAVVNTMGNTRASLTTATDGFRIRQEAISRGIPLFTSLDTVAAILKVMQSRSFTTKNI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: END8_CITK8
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFSQLKPYESPLIGQTVTHIETRGKALLTHFSQGLTLYSHNQLYGVWRVVETGNIPATTRVLRVNLQTADKTILLYSASDIEMLTPEQLATHPFLQRVGPDVLDPRLTPSDVKARLLSARFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLTGQHKAKDLSDQQLEALSHALLDIPRLSYTTRGQADENTHHGALFRFKVFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQT
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SEC63_PONAB
Sequence: MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD
What is the function of this protein?
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER).  Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides.  May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity).  Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
What are the official names of this protein?
Translocation protein SEC63 homolog.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MIAB_ESCF3
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2B_SULIL
Sequence: MSSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKICMKYLLKELAAPGNVDDKGELIIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEKKSWYIVCLACGAQTPVKPL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: VQSM_PSEAE
Sequence: MVTEHIFDFEWRPLQNYLRDRDIAIPPFAAEQESRSDALYNWIVSKGYSGKEGLNLGTYYHISDYGVIGLALLCAENVGDILKVIRAYVKLFNRDIANVGVKPRENYEVEIHISVNFKPEWNDASRQFHVNVIASATYKLIMDLLGNDFPISALTVPVHGADKTIYEGFFSLPVKHEGNDIIFSFPAHQLNRTLATANPAVFQSALTMAGESFNALLEVEMGGLRQRIELFLDSIPDQYPSLVTTAKYLRMNERTVRRRLADEGCTYRQIVDKARKERAIALLLNSSIPVDRISDILGYSETASFRHAFRRWTGQSTTEFRNSFH
What is the function of this protein?
Transcriptional regulator involved in both the repression (at least 99 genes, such as mexR and algU) and in the activation (at least 203 genes, such as mvfR, rsaL, vqsR and rpoS) of regulatory or putative regulatory proteins which are implicated in quorum sensing, virulence and multidrug resistance.
What are the official names of this protein?
HTH-type transcriptional regulator VqsM, Virulence and quorum sensing modulator protein.
Protein: HRCA_BIFLD
Sequence: MTQSRRMLVLRAVVEDYIRSQEPVGSTSLTRDHDLGVSSATIRNDMAALEDEGYLIQPHTSAGRVPTEKGYRYFVDRLATVVPLSEAQRRGINSFLSGSVSLKDALQRSARLLSEITGQVAVVASPSLAKATLRHVEMVPVAMTTLLAVVITDTGRVAQHGLTIASMPAVDEINRLSNTVNEQCDGLSLSKSAETVRSIAASAGYESVRGVADALADAFESMALDERANELYMSGTSHLAHSRSLADLAPLFDALEEQVVLMKLMSNLSEETNASGVGVAIGSEMHTPGLLHASVVSSGYGRSGAAGEPAGNDPVGEPETESETESQTNDTEPIAFVGSIGPTHMDYAATMAAVRAVARYLTAFLSEGRTQD
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: STE20_KLULA
Sequence: MTDTGYTEELLPGTFDALSVRENGGNTESDTSSIRKSQNQDSKQEDVHRENLSVQTLEDHTEVTETREQSVSKDLFDLPRAPASLDVKGLQESDEDHYVKDLSDYKSMDPGKPGTVPTNVSEIFNSNQPTLDEPIQFTRVSSSSVLSESISEGDADLISHLEGKVEEGNNLTSKETPGTIESIVGDKTMSTIEGSSQNIGRISTGGRMTPDLSLMGGALETSSDFLNSTQTSNSPKITTPITEVDANDVYESPLNEILSSTDSFNKASTASADHSKHVSVHEVIPEEEPHPETTNEDPPIKTPVMVNNFFENQTPVSESRSPFRTISSPFSSLRKNVKSQHGTPDHSQRNSNSSTSSNDVKRKTGTKKKGVFSTFVQNIKRNSHSEKRISSGSGNGSGNNAFKISTPYNAKHVYHVGVDSKTGEYTGLPNEWEKLLTSSGISMKEQQQHPQAVMDIVKFYQDVTENSGEEKVFKTFKVGGGSGANIASTPSFRTPSTASVQKFETPQMQTDATFPNENNDTPYSSNLQGPLLTNDFSETVNNEKFIPTRPAPKPQGSSTVSRRVEIPSPINSLGHGTPKVQRSDTQSSSIFSFKKMPTLKSEQPLPPIPKAAEKPANLLPARAAPTPPKPAIPTTPEQSSIPAIPSGLAVEVKEESNTSNVQTRKAQEKKREERKRKNQQIQSKLTEICTTGDPSKLYKNLIKIGQGASGGVYTAYELGTNASVAIKQMNLEKQPKKELIVNEILVMKGSKHNNIVNFIDSYLFRGDLWVVMEYMEGGSLTDVVTHCILTEGQIGAVSRETLKGLQFLHSKGVIHRDIKSDNILLSMNGDIKLTDFGFCAQINEVNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKDPGNLSHKMAMFLNWCLMVDPEDRGTAADLLEDPFITEIAEENTSLAPLVKLARMKKLAESMEDDENDEDKYDEQS
What is the function of this protein?
MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.  Phosphorylates histone H2B to form H2BS10ph (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase STE20.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ABHD3_HUMAN
Sequence: MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS
What is the function of this protein?
Phospholipase that may play a role in phospholipids remodeling.  May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position.  In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2.  In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.
What are the official names of this protein?
Phospholipase ABHD3, Abhydrolase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SYC_CLOB8
Sequence: MRVFNTLTRQKEEFIPIITGEVKMYVCGPTVYNFFHIGNGRTFIVFDTIRRYLEYRGYKVRFVQNFTDIDDKMINKANDEGITVKELGDKYIKEYYQDADSLKIERATVNPRATEYIHDIIKFVEELIEAGFAYEVDGDVYYSTKKFDNYGRLVGQNLDDLQVGARISVDERKKDPMDFAVWKAQKPGEPAWESPWGPGRPGWHIECSCMAKKLLGDTIDIHAGGMDLRFPHHENEIAQSEALTGKTFANYWLHAAFVNVDNKKMSKSLNNFFTAREVLEEYSSDAIRFLMLSGHYRIQINFTKELLDSAKSSIERLYNCINNLENLKDEVTKKLMDEAEEKYLKSLDKYREKFIEKMDDDFNTADAISVLFDLTKDINNNVNINSSSELCEKAESMVRELGNPLGILQDRIEKDLETEIQELIEKRQQARKNKDFALADKIRDDLKSRNIILEDTPQGVRWKKID
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGD_TRYBB
Sequence: MSMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTTEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCAFQTEIRAGLQNYRDMVALITSKLEVSIPVLSASLNYVTAMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQWPELQ
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.