PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_TRIL1
Sequence: MGLRREARELALQMLYAQDTLQGSLRDTLRGFREGVETGERTREFAEALVQGVMEHREAIDQAIVARSKNWALSRMPRVDLNIMRMAAYELMFKRDIPKKVSINEAIEIAKKYGDKESPAFVNGILDELEACPKDEERSDTE
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: FOS_SHEEP
Sequence: ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYAADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTS
What is the function of this protein?
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.  On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.  Has a critical function in regulating the development of cells destined to form and maintain the skeleton.  It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).  In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A.  This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Protein c-Fos, Cellular oncogene fos, Transcription factor AP-1 subunit c-Fos.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Fos subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires Tyr-dephosphorylation (By similarity).
Protein: STG1_SCHPO
Sequence: MTSQLEKEAREWIEETLHTKLNAQLDLLDQLQSGVILCRICKEALGANIRYKESNMPFVQMENISAFINYAQQVVHVPSQDMFQTSDLFERRNDEQVLRSIHSFSRYAAKMFPGKVRGLGPKLAEKKPRVFSAQQQREFREGVNSLQYGSFDMPTQGTEKIAFSRRRDPTGNMY
What is the function of this protein?
Has actin-binding and actin-bundling activity and is a component of the actin patch.  Stabilizes actin filaments against disassembly.  Cross-links F-actin and is required for the formation of the contractile F-actin ring.
What are the official names of this protein?
Transgelin, Calponin homolog 1.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the barrier septum.
Protein: CYSJ_KLEP7
Sequence: MTTQAPPSNLLPLNPEQLARLQAATTDFTPTQLAWVSGYFWGVLNQQSGAAVAAPAPAAEVPTITLISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIAAEKLLVVVTSTQGEGEPPEEAVALHKFLFSKKAPKLDGTAFAVFGLGDTSYEFFCQSGKDFDNKLAELGAERLLDRVDADVEYQAAAAEWRARVVEALKARAPVAAPAQLATSGAVNDIHTSPYTKEAPLTATLSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPQLVKELVELLWLKGDEPVTVEGKTLPLSEALQWHFELTVNTATIVENYATLTRSESLLPLVGDKAQLQQYAAATPIVDMVRFSPAQLDAEALIGLLRPLTPRLYSIASSQAEVESEVHVTVGVVRYEIEGRARAGGASSFLADRVEEDGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAQGKNWLFFGNPHFTEDFLYQVEWQSYVKEGLLTRIDLAWSRDQQQKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVENTLLEVIAEYGAMDAEAADEFLSELRVERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: MED31_USTMA
Sequence: MTLGAATANDPIDSTLASPSRDEQRRQANQAAFSRDLEFLSSLANPYYLNHLALSGALSSPSFKRYLKYLDYFRHPKYVKYLHYPQALHFLDLLQNEEEFRLACRDPAFAGEVMAKQIGHWATWRDPENAAGQEQDEAGEQGEARETTGGQTA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31, Mediator complex subunit 31.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FTSY_NEIMC
Sequence: MFSFFRRKKKQETPAPEEAQIQETVAKVESEVAQIVENIKEDAESLAESVKGQVESAVETVSGAVEQVKETVAEMLSEAEEAAEKAAEQVEAAKEAVAETVGEAVGQVQEAVATTEEHKLGWAARLKQGLTKSRDKMAKSLAGVFGGGQIDEDLYEELETVLITSDMDMEATEYLMKDVRDRVSLKGLKDGNELRGALKEALYDLIKPLEKPLVLPETKEPFVIMLAGINGAGKTTSIGKLAKYFQAQGKSVLLAAGDTFRAAAREQLQAWGERNNVTVISQTTGDSAAVCFDAVQAAKARGIDIVLADTAGRLPTQLHLMEEIKKVKRVLQKAMPDAPHEIIVVLDANIGQNAVNQVKAFDDALGLTGLIVTKLDGTAKGGILAALASDRPVPVRYIGVGEGIDDLRPFDARAFVDALLD
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).  Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: SK1_ELLSS
Sequence: EQFEDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, EllSp-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FES1_CRYNJ
Sequence: MPDINELLRWSIANSTAPDTDASEQLQIRFNPNSTQSGTSTLHASDSGPPDISPASTPGPVTPDDGSSLPLPPGTEVPVTKKEDLTTEMLDLILGKGDSITMKEKMAFATDENNSVEDRVEALDDFEMLIELIDNANNMPILKLWDPLLTLLSSSHPEIVAHTCWIIGTAIQNNIKAQAAFYIHETFSRILEIIYPPSSISSYPPSVRAKATYALSAALKHWPLASYALYTATSSAENGYSVLRRGVNDPQAIVRRKMAFLVGTLAMQSGERYEGEIPSEVRNYIEENEKNAPSESLVEGLKREGVFTALVDGLKQGVDDVEYEENAMRALVRAHQKGGLTVSEKSDLKTIWEKWGKQGRQERGLDGEDGKEVSETLSS
What is the function of this protein?
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP.  Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
What are the official names of this protein?
Hsp70 nucleotide exchange factor FES1.
What is the protein family that this protein belongs to?
Belongs to the FES1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_CROS8
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTDVKIKGFSGEDAKPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLIQQVATTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKKPAELDVPVIGGHSGVTILPLLSQIPGVNFTDQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGEYARFFSQPLLLGKNGIEERKPIGTLSAYEQQALEGMLDTLKKDIALGEEFVNK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: CRBA4_CHICK
Sequence: MIQRRRPSSGLWKIVVWDEPFFQGKRHEFTTDCYSTPERGFSTVRSFRIESGAWVGFEHCGFQGQQFVLERGEYPCWEAWSGSNAYHVDRMSSFRPITCAVHGRSQLLLFEQENFQGRRGELSDDCPSLPALGWGGSAVGSFLVCSGAWVCSQYPGYRGFQYLLESDTHAGEYKHVREWGSHAQTGQVQSIRRVQQ
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Beta-crystallin A4, Beta-A4 crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: PRS2_SOLTU
Sequence: MGVTSYTHETTTPIAPTRLFKALVVDSDNLIPKLMPQVKNIEAEGDGSIKKMNFVEGSPIKYLKHKIHVVDDKNLVTKYSMIEGDVLGDKLESISYDLKFEAHGNGGCVCKSITEYHTKGDYVLKDEEHNEGQKQGMELFKIVEAYLLANPSVYA
What are the official names of this protein?
Pathogenesis-related protein STH-2.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: CYHEE_AFREN
Sequence: GVPCGESCVYIPCFTGIINCSCRDKVCYNN
What is the function of this protein?
Probably participates in a plant defense mechanism (By similarity).  Has cytotoxic activity against HUVEC cells (LC(50)= 2. 17 uM) and various cancer cells including HeLa (LC(50)= 3. 05 uM), MCF-7 and K562 (PubMed:32414842).  Displays very weak hemolytic activity (PubMed:32414842).  Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (PubMed:32414842).
What are the official names of this protein?
Cyclotide hyen-E.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: DER_BACC0
Sequence: MPKPVIAIVGRPNVGKSTIFNRIVGERVSIVEDIPGVTRDRIYSAGEWLNHEFNIIDTGGIDIGDEPFLTQIRQQAEVAIDEADVIIFMTNGRDGVTAADEEVAKILYRSNKPVVLAVNKVDNPEMRSDIYDFYALGFGEPFPISGTHGLGLGDLLDEAAQHFPKIEEDGYDEDTIRFSLIGRPNVGKSSLVNALLGQERVIVSNVAGTTRDAVDTPYSKDGKDYVIIDTAGMRKKGKVYESTEKYSVLRALRAIERSDVVLVVLDGEEGIIEQDKKIAGYAHDSGRAVVIVVNKWDAVKKDEKTMKAFEENIRAHFQFLEYAPIVFLSAKTRKRTQTLIPVIDEVNESHSIRIQTNVLNDVIMDAVAMNPTPTHNGSRLKIFYATQVAVKPPTFVVFVNDPELLHFSYERFLKNRLRESFGFVGTPIHIIARARD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PRKX_HUMAN
Sequence: MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
What is the function of this protein?
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells.  Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis.  Regulates myeloid cell differentiation through SMAD6 phosphorylation.  Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis.  Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit PRKX, PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, Protein kinase PKX1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Protein: NU4LM_MICGI
Sequence: MPSISINITLAFTAALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNTQFTMSFIMPILLLVFAACEAAIGLALLVMVSNTYGLDHIQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL35_SULSY
Sequence: MAKVKMKTNRTAAKRLKITATGKVKYTKGGVSHYNTKKSSKRKRQGRKPQYVPKNLEHKVKALLPNDV
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RECX_STRU0
Sequence: MKIQKIEKKKRLYLLECDNGDSLYVTEDTIVHFMLSKGMEISPEQLESIKQFAQFSYGKNLALYYISFQVRTQKQVYDYLKKHDLENTIIQKIIEELIKENWINDQKYVESFLRQNMTNGDKGPQLIKQKLMQKGISDKIIEKAISEVDFYPIAEKAALKMISRYQDKLPRKALQDKLTQLLINKGFSYDLVKAVNGNLSIETDQENTLDLLEKEADKQLRKLSKRYEGYALRQKLFQALYRKGYDSDDIQSLLSEIL
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_CLOP1
Sequence: MSIKIENLNHIYMPKTPFEKIALNNINCEIEDGEFVALIGHTGSGKSTFIQHLNGLLSPTSGNIIVDGVNIADKKVKLSDIRKKVGLVFQYPEYQLFEETIEKDIEYGPRNLGISEEEISKRVKKSMEMVGLDYETYKDKSPFDLSGGQKRRVAIAGVIAMEPKVLILDEPTAGLDPKGREDILAQIRLLHKEYGMTIIMVSHSMEDVAKIADRVIVMNSGEIVLDGKIAEVFKEVETLEKIGLAVPQVTYLIRELRNKGFNISEEIFTISQAKEALLEIIRNNN
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y048_ATV
Sequence: MNCLEILISKGYNMQGYSPDTLLLLSEKEGNDVEECEAYFSWLEAVYG
What are the official names of this protein?
Uncharacterized protein ORF48.
Protein: SYTC_ENCCU
Sequence: MYEVKLKVELEDKVLEVTQGTTPYDILCDYFKDRKDVISCRIDGVYSDMSSEILKDCKLELMTFEDDGARDIFWHSSAHVLGNALVNLYPDAKLVHGPPIEEGFFYDVDVTDPISSEDYEKIEEEMVKIMKKNYRFERVIKSKEELLEAYRDNPCKTHFIMKGVDKESSVYRNGDFFDMCLGPHIRSTGVIKAVKVLKNSSAYFLNDPNLKSLQRIYAITFPSKGMMDEYLKRKEEAKERDHRKIGTELDLFFFSKYSPGSCFFLPNGTTMYNTLIEFLREEYRKRGFKEVITPNIFCTQLWEESGHLQNYKENMFIIEGDTFALKPMNCPGHCVMFRHQDHSFRDLPLRLADFGVLHRNELSGTLTGLTRVRRFQQDDAHIFCTKDQVKEEIKGCLEFLSFVYGVFGFRFELVLSTRPEKYLGSVDEWDRAEKALADAMDESNMPFKINAGDGAFYGPKIDITLHDALGRRIQCATIQLDFQLPQRFELKYRDSDGQCRTPVIIHRAILGSIERMIAIILESFGKRLPFWISPRQIAIVNMGNPDYVGKVRSVLARFRLDVIDDGNTLSKRIRTAETSGYALVCVVGKKEAEANEINIRFNKSNRNIGLYELRDILDRMADEKVELDSILPIDKVSISK
What are the official names of this protein?
Probable threonine--tRNA ligase, cytoplasmic, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C555_METCA
Sequence: MDHKKTSIRTTALAALVLGAVAAPAFSAPVDQATYNGFKIYKQQRCETCHGATGEGSAAFPNLLNSLKNLSKDQFKEVVLKGRNAMPPFEANKKVAEGIDDLYTYIKGRSDGTVPAGELEKPQ
What are the official names of this protein?
Cytochrome c-555, Cytochrome c555.
Protein: DYR_STRPN
Sequence: MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: DNLJ_LACGA
Sequence: MAVLTHNQASQKVDELRKKLDEWAEDYYAKDAPVVEDAVYDKAYQELVELEKQFPDLVTSDSITQRVGGEIKSDLSKVEHPVPMLSMGDVFSKDELKEFDERITKLVGHPVAYNVELKIDGLSLSLEYTAGKLTRASTRGNGRVGEDVTANAKFIKDIPQTLPEPLTTEVRGECYMEKEAFAKLNAERDEKGEQVFANPRNAAAGSLRQLDARITKKRNLSTFIYTWVNPPKNITSQHQAIDEMNRLGFHTNQTGQRLESMDEVFKFIDEYTAKRNDLSYGIDGIVLKVDDLSLQNELGNTVKVPRWEIAYKFPPEEQETVVKEIEWTVGRTGVVTPTAVMDPVQLAGTVVSRASLHNPDYLREKGVRIGDTVKLHKAGDIIPEISSVVLNKRPKDSEPYQIPNKCPSCGQDLVHLQDEVALRCINPMCPAQVEEGIIHFASRGAMNIMGLGPRIVKQLIDKNFVNDVADLYHLTNEQLSQLDHFKDKSITNLLTSIENSKQNSAELLLFGLGIDHVGAKAARLILEKYKNLEKVSQLTVPELTSIDTIGETIAESLTAYFNQPSAQKLLQELRDSGLNMEYLGTVEEEAPDNFFKEKTVVLTGKLSDFTRSEFTKKLQDLGAKVTGSVSKKTDYLIYGADAGSKKDKAEKLQVPMLTEQEAIAKIEK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HEMH_PSEA6
Sequence: MKYRSNETFTHKQADKIGVLITNLGTPEAPEKGALKRYLREFLSDTRVVEVPKLIWWMILNLVILNIRPKRSAHAYSTVWTDRGSPLMFHTQDQTNALATSMQQKYGDKVVVDFAMRYGSPSIESVTQNMLEKGVRQLLVLPLYPQYSGATNGSTFDALGEVLRKTRWIPDVRFISHYHDFTPYIDAVAGSITEHWATHGRADKLIFTYHGIPKRYLTAGDPYHCECYKTSRLVAEKLGLGKHEYMVTFQSRFGREEWLQPYTDHTLKSLPEQGVKSVQMICPGFSADCLETIEEIGIENRDYFLEAGGQRYEYIAALNAQPQHIAALESLIEKNLGGWECPDRNSQLSADLATAMGSDK
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS211_FRATH
Sequence: MLSIRVDEHKPFDISLRNFKRACEKAGIKQELRDRQHYVKPTEKRKIAKRQAVKRARISQRRAFI
What are the official names of this protein?
30S ribosomal protein S21 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: HNF4A_MOUSE
Sequence: MRLSKTLAGMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHTHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
What is the function of this protein?
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity).  Activates the transcription of CYP2C38 (PubMed:30555544).  Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
What are the official names of this protein?
Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCMK2_SYNE7
Sequence: MPIAVGMIETLGFPAVVEAADAMVKAARVTLVGYEKIGSGRVTVIVRGDVSEVQASVSAGLDSAKRVAGGEVLSHHIIARPHENLEYVLPIRYTEAVEQFRM
What is the function of this protein?
Beta-carboxysome assembly initiates when soluble RuBisCO is condensed into a liquid matrix in a pre-carboxysome by the RbcS-like domains of probably both CcmM58 and CcmM35.  CcmN interacts with the N-terminus of CcmM58, and then recruits the CcmK2 major shell protein via CcmN's encapsulation peptide.  Shell formation requires CcmK proteins and CcmO.  CcmL caps the otherwise elongated carboxysome.  Once fully encapsulated carboxysomes are formed, they migrate within the cell probably via interactions with the cytoskeleton.
What are the official names of this protein?
Carboxysome shell protein CcmK2, Carbon dioxide-concentrating mechanism protein CcmK2.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CcmK subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Protein: CMT_YEASX
Sequence: MIHCKVQQWSPQYLRLPATGYEELTLTLNTSMLARMPEEEDQLFLVVGDSPSSTYVDWGEDCNSTRYPSYDHCTHKILYLGASAGTTRSKRLSATIGIRLSKGTGSNNVLGTPMYLLYNEMKTRIIESSK
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-cysteine S-methyltransferase with broad substrate specificity.  Methylates trehalose-6-phosphate synthase (TPS), enhancing its enzymatic activity and promoting trehalose synthesis upon entry of cells into stationary phase.
What are the official names of this protein?
Cysteine methyltransferase, CMT.
Protein: FOLD_PARD8
Sequence: MEEQHYQLLDGKAVSAQMKKEMAEEVAQIKAAGGKIPHLAAILVGHDGGSETYVASKVKTCQEIGFKSTLIRFEEDVTEEELLRKVDELNNDPDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPAGILELLKRYHIETQGKHCVVLGRSNIVGKPMATLMMQKSYPGDCTVTVCHSRSKNLKEMCLSADIIIVALGVPEFLKGDMVKEGAVIVDVGTTRMPSSITKSGFKLTGDVLFNEVAPKCSYITPVPGGVGPMTIISLMRNTLLAGKKAIYK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CYOE_LEGPC
Sequence: MRTEYAARLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCAGSAAAINHLVDRHIDSIMARTKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTALLTFVTLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLGWTAVTDQLDPQALLLVLIIFTWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSGWIYLLGALVLGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.