PharMolix/UniProtQA huggingface dataset:
Protein: MED6_DEBHA
Sequence: MSKEPLDEIQWKNPEWIQQFGLFTGNVLDYFSESPFYDRTSNNQVLRMQFQFQQIPPNINPQKYLQSKLVEMTGIEFIIAASREPDFWIIRKQTRLSPKQVNIEQDYYIIGANIYQAPKVYDILSSRLLSSVLSIKGSMELLNKMSKFNIHDMGHSYPTLQAEKEISSSSNTIPNTVSVNTTTPMLHTPATASNINSNGHSSTNLGLNNEISNLAFDNLLNNVINSSNDDTYLEDIPLYGKGSTVESLGVKVNLDDV
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 6, Mediator complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: P53_XIPHE
Sequence: MEEADLTLPLSQDTFHDLWNNVFLSTENESLAPPEGLLSQNMDFWEDPETMQETKNVPTAPTVPAISNYAGEHGFNLEFNDSGTAKSVTSTYSVKLGKLFCQLAKTTPIGVLVKEEPPQGAVIRATSVYKKTEHVGEVVKRCPHHQSEDLSDNKSHLIRVEGSQLAQYFEDPNTRRHSVTVPYERPQLGSEMTTILLSFMCNSSCMGGMNRRPILTILTLETTEGEVLGRRCFEVRVCACPGRDRKTEEGNLEKSGTKQTKKRKSAPAPDTSTAKKSKSASSGEDEDKEIYTLSIRGRNRYLWFKSLNDGLELMDKTGPKIKQEIPAPSSGKRLLKGGSDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PANB_LEGPH
Sequence: MKIHDFKIKKQEQKKISMLTCYDYPSACIVAESNIDCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_SALPC
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALIEYDESLRGELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NADA_MICAN
Sequence: MFTTVQPTNRSSLPDDLFTAIKELKRELNAVILAHYYQNSDIQDIADYIGDSLGLSQQAARTPADVIVFAGVHFMAETAKILNPDKLVLLPDLDAGCSLADSCHPEDFARFKAQYPDHIVISYINCSAEIKAMSDIICTSSNAVKIVNQIPAHQPIIFAPDRNLGRYVSQQTGRDLVLWQGSCIVHETFSERKIIELKVAHPEAKIIAHPECEASVLRHADYIGSTTALLNYSLKSSEKTFIVATEPGIIHQMQKSAPEKLFIPAPALNNCACNECPYMRLNTLEKLYLCMRDKTPEITISEDLRVKALLPIQRMLEMS
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB_RHIME
Sequence: MNIMSEAAVEKALDQKMNTVPYKMIGNDVSVYYGEKRALFDVNLNIRENTVTALIGPSGCGKSTFLRTLNRMNDTIENCRVTGKITLDEDDIYDPSIDVVELRARVGMVFQKPNPFPKSIYDNVSYGPRIHGLARTKAELDEVVETSLQKAGLWNEVKDRLQEPGTGLSGGQQQRLCIARAVAVSPEVILMDEPCSALDPIATAKVEELIHELRANFTIVIVTHSMQQAARVSQRTAMFHLGNLVEENDTDKMFTNPDDQRTQDYIMGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1950_HALH5
Sequence: MRSIKVEHYEAFSTVPSKGNPAGIVLDGKGLTDSDRQKIAKEVGFNETAFPLPSERADVNIRFFTPGHEINLCGHATMATIYALKTKGLLPDRDEITIETKAGILPIRLSIDVDRSMMITMKQAAPQLRAFSGSRSELAASLALEEKDLHEELPVVYGSTGTWTLLIPIKKLDAFKRMQPNNQHFPHILQEMPRASVHPFCLETYDQEADMHARHFSSPYSGTVEDPVTGTASGVMGAYYHKYIESSPSLQLIVEQGHEIGKDGRIAVTVTEQTDDVMIEISGNAVLIREFEVRI
What are the official names of this protein?
Uncharacterized isomerase BH1950.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: HEM1_DESVV
Sequence: MERDIYLIGLNHRTAGVEVRERFALTDCNVLEQGVVPIDDVVSEVLILSTCNRVEILAVGRGPEVVSRVLRGWAAARGQCEHDLAPYVYTHKGHEAVRHLFRVASSLDSMVVGEPQILGQLKDAYRKAIERNCTRVILNRLLHKAFSVAKRVRTETGVASSAVSISYAAVELAKRIFGEMNQYKAMLIGAGEMAELAATHLLHAGISKIYVANRTFERGRELARQFNGEAIHFEDLFERLADADIIISSTGAHEAIIRARDIKDVLRRRKHRPMFFIDIAVPRDIDPDVNNLDNVYLYDIDDLKEVVEENLAQRREEASKALTIVEEETGKFGQWLRSLELQPTIVDLIRRSERIAQDELARTLKRLGPVDDETRDALEAMLSSMVRKLNHEPITFLKRRHSEEDAGPRYIDIARRMFNLDDDNVPPDAHCDRRRHDEDN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: EXP25_ORYSJ
Sequence: MEYAILFATSLVITVLAASGFAPAHGWNKGTATFYGGADASGTMGGACGYGNLYTAGYGTNTAALSSVLFNDGWSCGQCYLIMCDAAATPQWCRAGAAVTITATNLCPPNWALPSNSGGWCNPPRPHFDMAEPAWLQIGIYKAGIIPVLYQQVKCWRQGGIRFTMGGFNFFELVLVSNVAGSGSVRSVSVKGGSTGWITLNRNWGANWQCNSGLVGQALSFAVTSTGGQTLYIYNVVPSWWSFGMTFTSNQQFSY
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A25, Alpha-expansin-25, OsEXP25, OsEXPA25, OsaEXPa1.6.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: SYP_STAS1
Sequence: MKQSKVFIPTMKEVPAGAEALSHRLLLKAGLIKQSTSGIYSYLPLAARVLNNIEAIVREEMERIDAVEILMPALQQAELWEESGRWSAYGPELMRLQDRNGREFALGPTHEEVVTSIVRDELKSYKQLPLTLFQIQSKYRDEKRPRFGLLRGREFIMKDAYSFHADEDSLDASYQDMYNAYGRIFKRVGINARPVVADSGAIGGSHTHEFMALSEIGEDTIVYSEQSDYAANIEKAEVVYQANEKHEDLQPLTKIETPNIHTAQELATFLDKPLDEITKSMVFKIDGEFIMVLVRGHHELNDIKLKAYFGTDNIELASEDEIVNLLGAKPGSLGPVFDKEIKVYADNFIQDLNNIVVGANEDGYHLLNANIGRDFEVDAFGDFRFILEGEPLSDGSGPARFAEGIEVGQVFKLGTKYSESMNATFLDNQGKAQPLLMGCYGIGVSRTLSAIVEQNNDENGIIWPKSVTPFDLHLITINPKKDDQRELADQLYTQLKENYDVLYDDRKERAGVKFNDADLIGLPVRVVVGKNAAEGIVEVKRRDTGESEDVHVDNLINYVNTLYSNI
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSN3_MAGO7
Sequence: MSHSNPPTGASGGPGSASASAAPARGYYSLKRSIQTAFNDPLDRGLGPPAYQSKVRVMDKYQVIGFISSGTYGRVYKARGRQGQPGEFAIKKFKPDKEGEQITYTGISQSAIREMALCSELRHPNVIRLVETILEDKAIFMVFEYAEHDLLQIIHHHTQQPKHPIPPQTIKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSSGEVKVGDLGLARIFWKPVRTLMQGDKVVVTIWYRAPELLMGSHHYTPAVDMWAVGCIFAELLSLRPIFKGEEAKMDNTKKGGSRDMPFQRHQMQKIVDIMGMPTKERWPLLTSMPDYDKLPLLQPPLSASGYSQQPAHSHHHHQHYNQGPQYGGRAGGPTSSSSANSSSAAAAASQSHLDKWYYHTVSQGQTAGPMPHAPPGSLASLGVEGYKLLAGLLEYDPEKRLTAAAALQHNFFSTGDRVSANCFEGCKAEYPHRRVSQEDNDIRTGSVPGTKRSGMPDDSMGRPGKRVKE
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SSN3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARSI_MOUSE
Sequence: MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAGDQPSVAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHNPQNPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGGAWGPWASEEEEEEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSHRI
What is the function of this protein?
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
What are the official names of this protein?
Arylsulfatase I, ASI.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Note=Localized in the intracellular granular structures.
Protein: PNP_ACIBT
Sequence: MSMFNIVRKEFQFGQHQVVLETGRVARQANTVLITMGGVTVLVAVVAAPTAKAGQDFFPLTVNYQEKQYAAGRIPGGYGKREGRASEAETLISRLIDRPIRPLFPEGYYNEIQVTATVVSSDKTMEADIAAMLGTSAALAIAGTPFRGPIGAARVGLINGEYVLNPNFEQMAQSDLDLVVAGTESAVLMVESEAKELSEDQMLGAVLFGHDEMQIAIQAINEFAAAAGAKPSDWVAPAHNEELRAKLKEAFEAKISEAYTIAVKQDRYAALDALHAEAVAQFVPEEDVDGIADEVDYLFEDLKYRTVRDNILSGKPRIDGRDTKTVRALDVQVGVLERAHGSALFTRGETQALVTTTLGNTRDALMVDTLAGTKTDNFMLHYNFPAYSVGETGRESGPKRREIGHGRLARRGVQAVLPAADRFPYVIRIVSDITESNGSSSMASVCGASLSLMDAGVPLKAPVAGIAMGLVKEGERFAVLSDILGDEDHLGDMDFKVAGSANGITALQMDIKIEGITEEIMEVALNQAFAGRMHILNEMNKVISRARPEISMHAPTFEVITINPDKIRDVIGKGGATIRQITEETKAAIDIEDNGTVRVFGETKAAAKAAIAKIQAITAEVEPGKIYDGKVIRIVEFGAFVNIMPGTDGLLHISQISNERIANVTDVLKEGQEVKVQVQDVDNRGRIKLTMKDIEQA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR3_DRIGR
Sequence: MGKKINPLGFRLGANQSHRSLWFAQPKSYSRGLQEDEKIRDCIKNYVQKNMRSGSEGISHIEIKKKIDLIQVIIYIGFPNLLIEGRTRGIEELRINVQKGFRSVNRRLNIAITRVAKPYGQPNILAEYIALQLKNRVSFRKAMKKAIELTEQADTKGIQVQIAGRIDGKEIARVEWIREGRVPLQTIRAKIDHCSYTVRTIYGVLGIKIWIFVDEQ
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MUTS_THEP1
Sequence: MKVTPLMEQYLRIKEQYKDSILLFRLGDFYEAFFEDAKIVSKVLNIVLTRRQDAPMAGIPYHALNSYLKKLVEAGYKVAICDQMEEPSKSKKLIRREVTRVVTPGSILEDEFLSETNNYMAVVSEEKGQYCTIFCDVSTGEVLVHESSDEQETMDLLKNYSISQIVCPDHLKPSLKERFPGVYTESISEWYFSDLEEVEKAYNLKDIHHFELSSLALKTLAALIKYVKYTMITEELNLKPPLLISQRDYMILDSATVENLSLIPGDRGKNLFDVLNNTETPMGARLLKKWILHPLVDRKQIEERLETVEKLVSDRMNLEELRDLLSNVRDVERIVSRVEYNRSVPRDLVALRETLEIIPKLNEILSTFGVFKNLAFPERLLDLLQRAVEDDPAGSPGEGKVIKRGFSPELDEYRDLLEHAEERLKEFEEKERKRTGIQKLKVGYNQVFGYYIEVTKANLDKIPDDYERKQTLVNSERFITPELKEFETKIMAAKERIEELEKELFKNVCEEVKKHKEILLKISEELAKIDVLSTLAYDAILYSYTKPIFSEGRLEIKGGRHPIVERFTQNFVENDIYMDNERRFVVITGPNMSGKSTFIRQVGLISLMAQIGSFVPAQKAILPVFDRIFTRMGARDDLAGGRSTFLVEMNEMALILLKSTEKSLVLLDEVGRGTSTQDGVSIAWAISEELIKRGCKVLFATHFTELTELEKHFPQVQNKTILVKEEGKNVIFTHKVVDGVADRSYGIEVAKIAGIPDRVINRAYEILERNFKNNTKKNGKSNRFSQQIPLFPV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: MT_SYNE7
Sequence: MTSTTLVKCACEPCLCNVDPSKAIDRNGLYYCSEACADGHTGGSKGCGHTGCNCHG
What is the function of this protein?
May play a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions.  Binds four zinc ions (PubMed:11493688).
What are the official names of this protein?
Metallothionein, MT.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 14 family.
Protein: EIF3J_ASPOR
Sequence: MAPERWDDEEDSVSPPPVAPRRRFDDEEEDEVLDSWDAAEDSEVEREKAAKAAEAKAKADAEAAAKKKSKSQRIQEHKEERKKKAEEEDSDSEEEDDADKRARLRRAQKDADLKHAEDLFGDIDLNRNRGAPKAIVISDSADPTQAVDLSAMPLFKPTTKEQFARLTSTLIPLLTPHSKKPHYSLWAQEFAKQLVKELNSADVKKIASAMTTMSNEKMREERAADKGSKKSKAAKTKVSLVTSRDNKLDADYDNGDDGLGDDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 30 kDa subunit, eIF-3 30 kDa.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM1_ASPCL
Sequence: MLFSRSGHSIFPLLPPYAAHAPTTNQGHIITMPPDGLTPYLGLRARLSQVWINRWTILLLLVLVRVLMAASGLQADMGTAKREALSACSSVESMGSSMASMPHYLSQGVNELTASGVETAVSGLKSMLMLTVTGVEELVLFIIKVLYQTYLCLFTLAVRGSVHVAVGVIKDAADFLNSTVKEVGDDIGKVVSTFEDGFNKFLDSVNSVASVFGGSVPTLDLNSSISTLENLQLPSSIDKGLDKLNNSLPTFDEVNNFTQTVLRTPFEEVKKLVNQSLGTYTFDRSLLPIPAKEQLKFCEGNDGIDSFFDNVGDLVMTARKIFIAVLILAAVLACIPMAWQEIRRWRSMKERSQLVRKEAHDPMDIVYIVSRPYTAAAGIKAASRFSNSRRQILVRWAIAYATTPAALFVLCLGIAGLFSCLCQYLLLHAVEKTVPELSTQVGAFADKVVDKLENASAAWANDANGVIGHMNQDLNQNVFGWVNTSTTALNDTLNTFVDKTTGVLNETFGGTILYEPLMDVFGCLIGLKVAGIQKGLTWVHDHAHIDFPLLPNDTFSRGAAASIASNNSDASDSFLADAGDQTSNKITEVVIRVVDKVEEGIRMETIISTAILLLWVFIALVGIVRALTLFWMRDRSRGEGGGAPSTSHHTSDAGGFDDVPLTAIPNPSAHSAPAPRYEATISTVVASRAIPTSNSFQHQDEKMGFAGERQYGSALKVDGAPDLRGSAYVEYGVEKH
What is the function of this protein?
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
What are the official names of this protein?
Plasma membrane fusion protein prm1.
What is the protein family that this protein belongs to?
Belongs to the PRM1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS8_THEKO
Sequence: MIRNEVKAFKPYRVIEGNYRIWLDKNESPYDLPEELKEEIFEELKSVPFNRYPHITSMPAREAIGEFYGLPAENVAVGKGGDELIGYLVRLFEGDYIVTTPPTFGMYSFYARLNGIPVIEVPLREDFTIDGDTIAEKAKKASAVFIASPNNPTGNLQPVEEVLKVLETGKAVVVDEAYVEFAGKDLLGLLDEYPNLVLLRTFSKAFSLAGARVGYALASEEIIEALYRIKSPFSVDIFAQAVVKVVLRHPGLFRERIREIVRERERVRRSLGELAYPSDANFLLVKADAHSFLLERGIVVRKLSGRLKGHIRVTIGRRENDAFLKAMEEWKDVAGL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ST_POVS1
Sequence: MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGAWHSSEVGSDFPPCPDTLYCKDWPLCATKPSAHCPCMLCQLRNKHVYRKFLRRDPLVWIDCYCFDCFRQWFGLDLNEEALLWWSHIIGETPFRDLKL
What is the function of this protein?
Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle.  Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit.  Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters.  Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation.  May establish and maintain high levels of viral genomes during persistent infection in cell culture.
What are the official names of this protein?
Small t antigen, ST, ST-AG.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: FLIT_PHOLL
Sequence: MDNKMDLLSAYQRILSLSEQMLNLAKNEKWDELVDMEITYLKAVEVISHSSISSTTSLSLQQKMTNILQIILDNENEIKKLLQKRLDELSKLIKQASQQQLLNDSYGQFPVEPYHNTLMNSTEQK
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NFS1_HUMAN
Sequence: MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWTQH
What is the function of this protein?
May catalyze the desulfuration of L-cysteine to L-alanine as component of the cysteine desulfurase complex (NFS1:LYRM4), leading to the formation of a cysteine persulfide intermediate (PubMed:18650437, PubMed:16527810).  Acts as a sulfur donor for MOCS3 by transferring the sulfur of the cysteine persulfide intermediate on MOCS3 (PubMed:18650437).
What are the official names of this protein?
Cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
Protein: HPR_ALKCK
Sequence: MEEMDLNHPLKESIVFSHKMALLSKALWKSVEKDWQAWIKPFHLNLNEHHILWIAYQLNGATISDIASHGVMHVSTAFNFSKKLEARGLLSFSKKKDDKRNTYICLTDSGRQLFLETMRAFNEHTYHVYQGAVPMKELYGKFPEFSELICIVRHIYGTEFIEQFDACLTDFQNDVEEKDGHLKLASANLFPLQPAK
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: NP1L4_BOVIN
Sequence: MADNSFSDGVPSDSLEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVKCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSETEEEDKLAGDMKNKAVIAEKEAAAAEEPAPRGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPDDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNDSFFNFFSPLRASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEAEDDDDAEINPKKEPSQPSECKQQ
What is the function of this protein?
Acts as histone chaperone in nucleosome assembly.
What are the official names of this protein?
Nucleosome assembly protein 1-like 4.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase. Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary.
Protein: NDK_SALPA
Sequence: MAIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSLESAQREIAFFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHODL_HUMAN
Sequence: MSRVVSLLLGAALLCGHGAFCRRVVSGQKVCFADFKHPCYKMAYFHELSSRVSFQEARLACESEGGVLLSLENEAEQKLIESMLQNLTKPGTGISDGDFWIGLWRNGDGQTSGACPDLYQWSDGSNSQYRNWYTDEPSCGSEKCVVMYHQPTANPGLGGPYLYQWNDDRCNMKHNYICKYEPEINPTAPVEKPYLTNQPGDTHQNVVVTEAGIIPNLIYVVIPTIPLLLLILVAFGTCCFQMLHKSKGRTKTSPNQSTLWISKSTRKESGMEV
What is the function of this protein?
May play a role in the development of the nervous system such as in neurite outgrowth and elongation.  May be involved in motor axon growth and guidance.
What are the official names of this protein?
Chondrolectin, Transmembrane protein MT75.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: NIKR_SALG2
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRGALAQEATQEHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.