PharMolix/UniProtQA huggingface dataset:
Protein: DNAA_AROAE
Sequence: MSQDLWSFCLSRLEHELPPQQFNTWIKTLQADEEKAGASVALRLVAPSRFVLQWVRERYLRRIGELGAEFHGAPIEIELVLPAAGAARPAARPVIGSGPVAGPAPAPTPSQAPAATAAAPAVVTRPAEPESSIVTASDLAYEKTRLNADFTFDTLVTGRANDLARAAAMQVAQNPGTSYNPLFVYGGVGLGKTHLVHAIGNAVYRHNPRAVIRYVHVEDYYADVVRAYQQKSFDAFKRYYRSLDLLLIDDIQFFNNKNRTQEEFFHAFNALTEARKQIVITCDTYPKDIQGLEDRLISRFDWGLTVQIEPPELEMRVAILQKKAEALRVDLHDDVAFLIAKNLRSNVRELEGALNKVVAFARFHGRGITLEVAKDALKDLLNAHNRQLTIEHIQKTVADYYKIKVADMHSKKRTRVIARPRQVAMWLAKDLTPMSLPAIGEAFGGRDHTTVMHACRTIAELRLGDHQLNHDVHVLTQVLRG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_CLOB8
Sequence: MPRKGHIAKRDVLPDPVYNSKVVTKFINSIMEDGKKGVAQKICYEAFGLIAKRSGKEALEVFEEAMNNVMPLLEVKARRIGGATYQVPIEVRPERRQTLGIRWMLIAARKRGEKLMSERVAGELLDASNNTGAAVKKREDTHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SUBI_SHIFL
Sequence: MNKWGVGLTFLLAATSVMAKDIQLLNVSYDPTRELYEQYNKAFSAHWKQQTGDNVVIRQSHGGSGKQATSVINGIEADVVTLALAYDVDAIAERGRIDKEWIKRLPDNSAPYTSTIVFLVRKGNPKQIHDWNDLIKPGVSVITPNPKSSGGARWNYLAAWGYALHHNNNDQAKAQDFVRALYKNVEVLDSGARGSTNTFVERGIGDVLIAWENEALLAANELGKDKFEIVTPSESILAEPTVSVVDKVVEKKGTKEVAEAYLKYLYSPEGQEIAAKNYYRPRDAEVAKKYENAFPKLKLFTIDEEFGGWTKAQKEHFANGGTFDQISKR
What is the function of this protein?
This protein specifically binds sulfate and is involved in its transmembrane transport.
What are the official names of this protein?
Sulfate-binding protein, Sulfate starvation-induced protein 2, SSI2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic sulfate-binding protein family.
What are the subcellular locations of this protein?
Periplasm.
Protein: WLS_DROER
Sequence: MSGTILENLSGRKLSILVTTLLLCQVLCFLLGGLYAPLPAGHVTVLGSLCREDHGRQNDTGFLLYSRGAGACIPVTREEVEQDSTKMANELVHVFQMPLPRDLRDLDYSRWQQNLIGVLQVEFGYDSSSELREPPRELQLTIDMRLAYRNKGDPDNGWKLYAHGVEHRYLDCVSSHVGPTETLYSCDMIPLFELGALHHSFYLLNLRFPLDTPSQMNLQFGHMHDLTLTAIHQNGGFTQIWLLLKTVLFPFVVGIMIWFWRRVHLLQRSPALLEYMLIYLGAALTFLNLPLEYLSLVFEMPYMLLLSDIRQGIFYAMLLTFWLVFAGEHMLIQDAPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSIWAMPLAAKMAMTFIVLAGVSAAIYFLFLCYMIWKVFRNIGDKRTSLPSMSQARRLHYESLIYRFKFLMLATIVCAALTVTGFIMGQRAEGQWDWNDNVAIQPTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMHHSDETTQSNENIVASAASEEIEFSHLPSDSNPSEISSLTSFTRKVAFD
What is the function of this protein?
A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells.  In non-neuronal cells wls directs wg secretion.  The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26).  In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles.  Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip (By similarity).
What are the official names of this protein?
Protein wntless.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=In non-neuronal cells, wls binds to wg in the Golgi and accompanies it to the plasma membrane where the two proteins dissociate. Wg is secreted and wls is then internalized and returns to the Golgi apparatus in a retromer-dependent manner. Wls and wg colocalize in the Golgi apparatus in wg-producing cells, and reduced expression is seen in non-producing cells. Endoplasmic reticulum expression is unchanged in wg-producing versus non-producing cells. In neuronal cells, wls is localized both pre- and postsynaptically and is transferred trans-synaptically from the pre- to the postsynaptic compartment (By similarity).
Protein: Y027_YERPS
Sequence: MASFRRFRLLSPLKPCVTFGRMLYTRIDKDGLTMLAGHLAYVSLLSLVPLITVIFALFAAFPMFAEISIKLKAFIFANFMPATGDIIQNYLEQFVANSNRMTVVGTCGLIVTALLLIYSVDSVLNIIWRSKIQRSLVFSFAVYWMVLTLGPILVGASMVISSYLLSLHWLAHARVDSMIDEILRVFPLLISWVSFWLLYSVVPTVRVPARDALIGALVAALLFELGKKGFAMYITLFPSYQLIYGVLAVIPILFLWVYWSWCIVLLGAEITVTLGEYRAERHHAKSVITQSPEM
What are the official names of this protein?
UPF0761 membrane protein YPTB0027.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATG15_COCIM
Sequence: MMTPSQWKDDICTSQLAMVACAIFLLLPIFSPVVFATGLESHRNLQVPFVQPEDLGFLPQRSPQGHEFALRHIFHHGTYQYPLLHKRLDVNPETKIWVASEDGAKLEFSPHFRVSSQPSQIQRLTDRRVQVMEARLSAARTPEVFSTLSPPVWTIDELPGPNISDKTTVLNLAKMTANAYIMEPGAERWEDVSGPFNQSLSFGWEKDGLRGHIYADQTNSTIIIALKGTSAALFDGDETTTNDKINDNLFFSCCCGQGGQYFWRQVCDCYSSAYTCNSTCLVSALVTENRYYRASLDLYANVTDIYPNSTVWLAGHSLGGAVSSLLGLTYGLPVVTFEGVPEALPASRLGLPVPPGTDPNTPQAREYTGAYHFGHTADPVYMGTCNGATSFCTLAGYAMESACHTGQRCVYDTVGDLGWRVGIGTHRILNVISDVIERYEDVPTCVPDTECRDCALWKFFESNGSHPIPPSSSTTSPTRTRTSTCETPGWWGCLDKTTTTGTTTNVITTSTSTCKTPGWFGCKDPTTTSSVPSATPSPTPIITSISMPTPTSTTCETPGWFGGCNDPPTTATSKPNSSSPSTSTTCTRPGFFWGCWDPTSSSETPTAAFSSTATHTSCASKTWFGRSCTTPAPR
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: CAVN3_BOVIN
Sequence: MGESALESGPVPGAPAGGPVHAVTVVTLLEKLATMLETLRERQGGLAQRQGGLAGSVRRIQSNLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEAEIPAKAFQKAPEPLGPVELGPQLPEAEAEESSDEEEPVESRARRLRRTGLEKVQSLRRALSGRKGHAAPTPTPVKPPRLGPGRSAEGQWEAQPALESKLEPEPPQDTEEDPGRPGAAEAAAVLQVESAA
What is the function of this protein?
Regulates the traffic and/or budding of caveolae.  Plays a role in caveola formation in a tissue-specific manner.  Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells.  Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface.  Plays a role in the regulation of the circadian clock.  Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.
What are the official names of this protein?
Caveolae-associated protein 3, Cavin-3, Protein kinase C delta-binding protein.
What is the protein family that this protein belongs to?
Belongs to the CAVIN family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane, caveola. Cytoplasm, cytosol. Note=Localizes in the caveolae in a caveolin-dependent manner.
Protein: ATPG_HALOH
Sequence: METMRDIKRRINSIKNTQKITKAMKMVAAAKLKKAQLKAENARPFFEKTRSILIDVARRTRQKDIHPLLREKENNRSLFVMITADRGLCGAYNARVIDRVKKLTEKEDEVNFLAVGRKGRDFFGKRGYNIISEYINIDDYPDYSLAGKIGEEIISLFLDDVVDRVVLVYTYFNSAISQEVRDLTLLPLTPPDDKNQEEGKINTEYLYEPSPEAVMDILLPSYIKNILYSALIEAKASEFGARMTAMDAATDNAGELIDKLTLSYNRARQAAITKEITEIVGGAEALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRC_GEOUR
Sequence: MNLLIKGGRVVDPSQNIDDTMDLLVEDGRIKEIGKGLKAPAGAEIIDAAGLLVTPGLIDMHVHLRDPGLEYKEDIVTGTRAAAAGGFTSVACMPNTKPVNDNKAITSYIVNKAAKEALVNVFPVGSITQGSKGESLAEMGELKESGCVAVSDDGRPVVNGELMRRALEYAKGMGIMVISHSEELALVGEGVMNEGFTATELGLKGIPWAAEDVAVARDVYLAEFTDSPLHIAHISTSGSVRIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLREAADVAAIKAGLADGTIDAIATDHAPHHLDEKDLEFNLALNGIVGLETSLPLSLQLVEEGVVDLKVLLEKMTCNPAKILGIDRGTLKVGAAADITVIDPDREWLVAAEKLASKSKNSPFIGRKMKGAAVYTVVGGKVVYKID
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: COAX_CLOAB
Sequence: MILVLDVGNTNIVLGIYNDTKLTAEWRLSTDVLRSADEYGIQVMNLFQQDKLDPTLVEGVIISSVVPNIMYSLEHMIRKYFKINPLVVGPGIKTGINIKYDNPKEVGADRIVNAVAAHEIYKRSLIIIDFGTATTFCAVRENGDYLGGAICPGIKVSSEALFEKAAKLPRVELIKPAYAICKNTISSIQSGIVYGYIGQVRYIVERMKEELQEEGEKEPLVVATGGLAKLISEEAKNVDVINPFLTLEGLRIIYEKNRVKVI
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_BIFAA
Sequence: MKITLITVGKVKEKYLRDAIAEYSKRLGRYCKLGIVEVADEKTPEHASDGLERQIKAKEGERIAKHIRDDAFVIALAIEGKQLTSEQLAAKINDLGLHGTSHIQLIIGGSLGLDPAILKRADYLLSFSKMTFPHQLMRVILLEQIYRAYKINAGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_ACTPJ
Sequence: MRIDTSALCDIYSDQVDVVEPIFSSFGGASSFYGKITTVKCFESNGLIASVLEEEGQGRVLLIDGGGAVRRALIDAELAQLALDNGWEGIIVYGAVRQLDVLETLDIGIHALAPIPVGADDNEIGEVDTPVNFGGVTFFPEDYVYADLTGIILSPELLDLAELEE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_LEPIN
Sequence: MIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SYA_PSYCK
Sequence: MSQPFRSADIRQAFIDFFISKQHTPVASSSLIPHNDPTLLFTNAGMNQFKETFLGMEPRDYTRAVTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKQAGIGYIWEFLTSDEWLAIDKNRLYVTIYETDDEAFDIWHKDIGIPSERIIRIGDNKGAPYASDNFWTMGDTGPCGPCTEVFYDHGADIEGGLPGTPEEDGDRYIEIWNCVFMQFNRQKDGSMLPLPAPSVDTGMGLERISAIMQGVHGNYEIDLFVHLMDAAAEILEIENQQQSSLKVIADHIRAVSFLIADGVTPSNEGRGYVLRRIIRRAVRHGNKLGADSEFFYKMVAPLVAEMGTAYPELKDKQSVIENAIQKEETQFAKTLAQGLRLLASELEGLKDGDTLSGEAAFKLYDTYGFPVDLTADITRERGIVIDEAEFDEHMQAQRERARDAGKFDVDYSSVIQVENPTTFIGYEQLEEEGVTIDALYQDGNPADSLTEGMEGVIVLDRTPFYAEGGGQVGELGEIRTASGVFEVQDTKKSGQAIIHYGVVTMGDISTKQTADAQVLSSIRAASAKNHSATHLLHAALREVLGDAVTQKGSLVSSEVLRFDFSYDKPVSTAEITRIERLVNEQIQANTPARIENMSIDEAMKQGAMALFGEKYGSDVRVLTMGTGSIIDGQRKPFSIELCGGLHVKRTGDIGVLKITSESGIAAGIRRIEAVTGMNAIKNIQQSEQQLSELASQLKVKRPEVAQRVRTMADKQRELEKQLERLEQKIASAQAANLLDDVQTIAGTPVLISTLSGIDGKSIRTLMDDIKSKLPDSVIVLIGDKDEQLALAASVAKSVTAKVKAGDIIRHLASELGGKGGGKPDYAQGGAPKAANTNAVVNALPAWIADQLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWC2_KLULA
Sequence: MTGDWKNRPARVQLQESDLPSSVPPQTGLAFNVWYNKWSQGQSGSTRFVTPYSLDPENDSGITKGDKEGRIHFCLYFAKGMCCLGKNCRYLHHIPEPDDFARLALHSSALDCFGREKFADYRDDMGGVGSFKKPNRVLYVGGITGALNNKTLKPHQIENRVKYKFGKLGELDSVRYVESKNCAFVKFKLQCNSEFTKEAMGNQTLLIPTDKEWDLRKEGTGLLVKWANEDPNPAVRKRELEEQTQETLKAIKQLVASTEGTVNQKRKVEEINEVRDSQANSRERFSIRENAIIDKTILDKLKQRKVTITNTNVAANITVSKPSSVLPLVTQYSSDED
What is the function of this protein?
Involved in the first step of pre-mRNA splicing.  Required for cell growth and cell cycle control.  Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex.  May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA.  Associates predominantly with U6 snRNAs in assembled active spliceosomes.  Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC2.
What is the protein family that this protein belongs to?
Belongs to the RRM CWC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOB_BRUMB
Sequence: MAQTHSFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVEEPSGGRPDEGLQAVFKSVFPIQDFSGASMLEFVRYEFDPPKFDVDECRQRDLTYSAPLKVTLRLIVFDIDEDTGAKSIKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFAARVIPYRGSWLDIEFDSKDIVYARIDRRRKLPATTLLMALGMDGEEILSTFYKTVTYTRDGDNWRIPYSAERFKGMKIISDLVDADTGEVVLEAGKKLTARAAKQLAEKGLKAIKATEDDLFGSYLAEDVVNYATGEIYLEAGDEIDEKVLKTLIDTGETEINVLDIDHVNIGAYIRNTLAVDKNESRQEALFDIYRVMRPGEPPTMDSAEAMFHSLFFDSERYDLSAVGRVKMNMRLDLDAEDTVRVLRKEDILAVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKVVDGKVTNDVVYLSAMEEAKHSVAQVNVELDEQGGFVDEFVICRHAGEVMMAPRENVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRAEAPFVGTGMEPIVARDSGAAIAARRGGIVDQVDATRIVIRATEELDPSKSGVDIYRLQKFQRSNQSTCINQRPLVRVGDRIHKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSEKIVSDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVHPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTYGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYGRLVDMIDGKVAAAGPKGFKKGTTITRELMTEYPRSQWWQFAVEDEKLQGELEALRSQYDDSKKLLEARFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGELLDVYRKTANIEPLRQTLEHIYPDNDRNEPVRSYDDDAILMLANQVKRGVSIATPVFDGAVEADINAMLTDAGLATSGQSTLYDGRTGEPFDRQVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELDDTREAEQPALPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: TEBP_MOUSE
Sequence: MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
What is the function of this protein?
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).  Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.  Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
What are the official names of this protein?
Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Sid 3177, Telomerase-binding protein p23.
What is the protein family that this protein belongs to?
Belongs to the p23/wos2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ALIF1
Sequence: MNLTTMGQAAKAAAFDLAVAPTAQKNKALAIIADELEANKDAILAANEKDIKAAVEAGISEAMQDRLLLTEERLVGIANDVRNVINLNDPVGSEIDSKVLENGMSLSRRRVPIGVIGVIYEARPNVTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALEKAGLPAASVQYIEKPDRELVSQLLTMDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDESADLERALVVVDNSKAQRPSACNALDTLLVHEAVAPQFLALLANNMAGRVELVAEPKAYGLLKEFEGVSLREAQEGDFDTEWLSYTLGVKVVADVNEAAAHMQKHNASHSDTILTNNIESAEKFINTAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKADYLIRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_THEYD
Sequence: MKNVVLETNLKGVKLLRRGKVRDIYEIEDYLLIVATDRVSAFDVVLPTGIPEKGKILTQISLFWFDKVKDIVENHLVSANADEFPEPLPAYKEILEGRSMLVKKAKPLPVECIVRGYLSGSGWKDYQKTGMICGIKLPEGLVESAKLPEPVFTPSTKAEQGHDINISFEETIQILGEETAQKVKELSLSIYKKAAQIAEKKGIIIADTKMEFGFYNGKLILIDELLTPDSSRFWSLENYRIGYPQDSYDKQIVRDYLLSIKWDKKPPAPQLPEDIVNKTAERYKEIFRILTS
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y1041_STAAS
Sequence: MTKYTFKPKDFKAFNVEGLDARMEALNEYIRPQLHELGEYFSDFFTSQTGETFYPHVAKHARRSVNPPKDTWVAFATNKRGYKMLPHFQIGMFEDQLFVMFGIMHEAKDKATRAKVFERNFKAIQQLPDDYRVCLDHMKPDKPFIKDLTDDDLKEAIQRAINVKKGEFFIARAITPQDKRLKSDKAFIAFLEETFDQFLPFYSA
What are the official names of this protein?
UPF0637 protein SAS1041.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.
Protein: YBHH_ECOL6
Sequence: MKKIPCVMMRGGTSRGAFLLAEHLPEDQTQRDKILMAIMGSGNDLEIDGIGGGNPLTSKVAIISRSSDPRADVDYLFAQVIVHEQRVDTTPNCGNMLSGVGAFAIENGLIAATSPVTRVRIRNVNTGTFIEADVQTPNGVVEYEGSARIDGVPGTAAPVALTFLNAAGTKTGKVFPTDNQIDYFDDVPVTCIDMAMPVVIIPAEYLGKTGYELPAELDADKALLARIESIRLQAGKAMGLGDVSNMVIPKPVLISPAQKGGAINVRYFMPHSCHRALAITGAIAISSSCALEGTVTRQIVPSVGYGNINIEHPSGALDVHLSNEGQDATTLRASVIRTTRKIFSGEVYLP
What are the official names of this protein?
Putative isomerase YbhH.
What is the protein family that this protein belongs to?
Belongs to the PrpF family.
Protein: MMM1_ASPFC
Sequence: MSSQLNDPTPIPAQSSLSFTQGFFLLGQLSVVLLIAAFIKFFIFGEAPPPPSRGLSHRSATHRRSNSIFSSAQHDGSTRTLREKPSNSNVLRPVPSSATNTRSILRKTYYTAIPTNPSSKHGRHRIHHSSHQPESLDWFNVLIAQTIAQYRQTAYLLKDSPTSSILNSLTAALNNPEKKPSFIDKITVTDISLGEEFPIFSNCRIIAVDDPNSDGGRLQALMDVDLSDDNLSIAVETQLLLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLDTPSHSPSPPTAQTTTAGRSKREDQTSGSHSHAGGSSKEPSGENPPKTSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVHAWFEERVVEPRVQVVGLPDLWPRMGRTGVRTGDDSETGSNVPRSSTAADASGSARHEDSSREPEVLRFGSLLGTRPPFDLASRTSSFNVETGDLRSRSMTREESNGNLSDQFHMPGSLPGSGVATT
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: AZOR_STRMK
Sequence: MKLLHLDASVLGDNSVSRQLSAAVVARFTGQIDGLQVDYRDLDANPVPHLRSSSLARTDAAEATDAEQVMQQFLDADIVVIGAPMYNFSIPSTLKAWIDRVAVAGRTFKYTENGPVGLASGKRVIIASSRGGIYTDSPADFQEPFLRQVFAFMGINEVEFVRAEGIAYSPQHREDAIAGALAALPSHEVVEAVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: AMYR_DROPS
Sequence: MFKFTFALALCVLAAGLVLAQHNPHWWGNRNTIVHLFEWKWEDIAEECENFLGPRGFAGVQVSPANENIVSPGRPWWERYQPISYKLITRSGNEEQFADMVRRCNEVGVRIYVDVLLNHMSADFVGQAVGTAGTEADPAVKSFPGVPYSAEDFHPSCEIYDWNDRYQIQHCELVGLKDLDQSRDWVRTKLIEFLDHLIELGVAGFRVDAAKHMASEDLEFIYGSLSDLKIEHGFPHSSRPFIFQEVIDHGGQEVTREEYNSLGAVTEFRFSQEIGNAFRGNNALKWLQSWGTDWGFLSSGQALTFVDNHDNQRDGGAVLTYKSPRQYKMATAFHLAYPYGISRVMSSFAFDDHDSAPPQDAQEELISPEFDADGGCANGWICEHRWRQIYNMVGFKNAVRDTEISNWWDNGDSQIAFCRGSKGFIAFNNNMYNLAEVLQTCLPKGVYCDVISGDLINGSCSGKSVYVGDDGLGFVSIDSDDFDGVLAIHVDARI
What are the official names of this protein?
Alpha-amylase-related protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.