PharMolix/UniProtQA huggingface dataset:
Protein: CP3AI_RAT
Sequence: MEIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIFNYGDGMWKFDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQPEGPIILKLVSRD
What is the function of this protein?
Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.
What are the official names of this protein?
Cytochrome P450 3A18, CYPIIIA18, Cytochrome P450(6)beta-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: KDSB_SALCH
Sequence: MSFVVIIPARFSSTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCGFSDDTVIVNVQGDEPMIPAVIIRQVAENLAQRQVGMATLAVPIHSAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAKSLETVGDTCLRHLGIYGYRAGFIRRYVSWQPSPLEHIEMLEQLRVLWYGEKIHVAVAKAVPGTGVDTADDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_AGRRK
Sequence: MNTLDFDKKPEDTRVVVAMSGGVDSSVVAGILKRQGYDVLGITLQLYDHGAAVHRAGSCCAGQDIDDARRVCETIGIPHYVLDYEKRFRETVINPFAESYVAGETPIPCVSCNQTVKFADLLATAKELGADALATGHYIRSRPNPSADHPGRRALYRPADADRDQSYFLFATTQEQIDYLRFPLGGMPKAETRALAEEMGLVVAKKADSQDICFVPQGKYSDVIAKLKPNAALAGEIVHLDGRVLGRHEGILHYTIGQRRGIGVATGDPLYVVFLDARSRRVIVGPKEALETHRVYLRDVNWLGDEPLLEAASGEGFACYAKVRSTRPPEPAVLRADKDGIYVDLTIGEAGVAPGQACALYSAPGDDARVYGGGFIERSEREPMAEASLKALLASPVAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_PSET1
Sequence: MSVNLWAPSASIATLKQRAVILRSIREFFYARNVMEVETPSLSGASVTDIHLVSFNTRFVGPGHASGLELYLQTSPEFAMKRLLAAGSGPIFQLCKAFRNEEAGSHHNPEFTMLEWYRPGFDEFALMAEIDELMQLILDVAPSERLTYQHAFEQVLGLDPLTASLEQLQQLACEQGFADIAKNETHRDTLLQLLFCMKVEPTIGQHKPCFVYHFPASQAALAQICDHDSRVAGRFELYYKNMELANGFNELTNATEQAKRFNDDNEYRKQNGLKQVPMDKHLIAALEHGLAPCAGVALGIDRLVMLATQKSNIKEVIAFDVTRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: RPOB_MAIZE
Sequence: MLRNGNEGMSTIPGFSQIQFEGFCRFINQGLAEELEKFPTIKDPDHEIAFQLFAKGYQLLEPSIKERNAVYESLTYSSELYVSARLIFGFDVQKETISIGNIPIMNSLGTFIINGIYRIVINQILLSPGIYYRSELDHKGISIYTGTIISDWGGRSELAIDKKERIWARVSRKQKISILVLSSAMGSNLREILDNVSYPEIFLSFPNAKEKKRIESKEKAILEFYQQFACVGGDLVFSESLCEELQKKFFQQKCELGRVGRRNMNRRLNLDIPQNNTFLLPRDVLAATDHLIGMKFGTGILDDDDMNHLKNKRIRSVADLLQDQFGLALGRLQHAVQKTIRRVFIRQSKPTPQTLVTPTSTSILLITTYETFFGTYPLAQVFDQTNPLTQTVHGRKVSCLGPGGLTGRTASFRSRDIHPSHYGRICPIDTSEGINVGLTGSLAIHARIDHWWGSIESPFYEISEKAKEKKERQVVYLSPNRDEYYMIAAGNSLSLNQGIQEEQVVPARYRQEFLTIAWEQIHVRSIFPFQYFSIGGSLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQTALDSRVSVIAQREGKIISSDSHKILLSSSGKTISIPLVAHRRSNKNTCMHQKPRVPRGKSIKKGQILAEGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTDTTSQGSAEKITKQIPHLEEHLLRNLDRNGVVRLGSWVETGDILVGKLTPQIASESSYIAEAGLLRAIFGLEVSTSKETSLKLPIGGRGRVIDVKWIQRDPFDIMVRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGAPVDMVFNPLGVPSRMNVGQIFESSLGLAGDLLKKHYRIAPFDERYEQEASRKLVFSELYEASKQTKNPWVFEPEYPGKSRIFDGRTGDPFEQPVLIGKSYILKLIHQVDEKIHGRSTGPYSLVTQQPVRGRAKQGGQRIGEMEVWALEGFGVAHILQEILTYKSDHLIARQEILNATIWGKRMPNHEDPPESFRVLVRELRSLALELNHFLVSEKNFQVNREDV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CHEB2_CAUVC
Sequence: MRVMIVDDSAVVRGMVTRWLEEAGFIIAAIAVDGGQALRKLADTSVDVCLLDIEMPVMSGLEALPKLLAAKPDLRVIMASTLTERGAEVTLRALDLGAADYIAKPSANKLGGADLYRKDLIEKVRHLGARAARPAPPQAAPRPTLAPPSSDPAGPIEAVVVASSTGGPPALRRFIAGLGADWTSPILIAQHMPPGFTRTLAQMLDPISHLTAREAQNGEPIVPGVIYVAPGDYHMTVRAAGGGGPSIHLDQGPEVNYCRPSADPLFESAARFWKGRVLGVVLTGMGRDGRDGAAVLAKVGGTIIAQDEATSVVWGMPGAVANAGLAEAVLPLDQIGPYIASRARSVA
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGE_STRCO
Sequence: MAVAAPSPAAAAEPGPAARPRSTRGQVRLPGGEFAMGDAFGEGYPADGETPVHTVRLRPFHIDETAVTNARFAAFVKATGHVTDAERFGSSAVFHLVVAAPDADVLGSAAGAPWWINVRGAHWRRPEGARSDITGRPNHPVVHVSWNDATAYARWAGKRLPTEAEWEYAARGGLAGRRYAWGDELTPGGRWRCNIWQGRFPHVNTAEDGHLSTAPVKSYRPNGHGLWNTAGNVWEWCSDWFSPTYYAESPTVDPHGPGTGAARVLRGGSYLCHDSYCNRYRVAARSSNTPDSSSGNLGFRCANDADLTSGSAAE
What is the function of this protein?
Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins.  3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.
What are the official names of this protein?
Formylglycine-generating enzyme, FGE, sc-FGE.
What is the protein family that this protein belongs to?
Belongs to the sulfatase-modifying factor family.
Protein: RL9_YERPP
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARATKINELVSVTISSKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTAGEHEVHFQVHSDVFAKLNVVVVPEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PURA_MYCTO
Sequence: MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCOA2_MOUSE
Sequence: MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQGGYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLMMRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQANTSMYSNNMNISVSMATNTGGLSSMNQMTGQMSMTSVTSVPTSGLPSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDASRKYC
What is the function of this protein?
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140, PubMed:31851938).  Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).  Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).  Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).  Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).  Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (PubMed:24529706).
What are the official names of this protein?
Nuclear receptor coactivator 2, NCoA-2, Glucocorticoid receptor-interacting protein 1, GRIP-1, Steroid receptor coactivator 2, SRC-2, Transcriptional intermediary factor 2.
What is the protein family that this protein belongs to?
Belongs to the SRC/p160 nuclear receptor coactivator family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YAJC_HAEIN
Sequence: MEAQSPMSTLFIFVIFGLIFYFMIYRPQAKRNKEHKKLMSELAKGTEVLTAGGVIGKITKVTEGSDSIVIALNDTTEITINRNYIVSVLPKGSLKSL
What is the function of this protein?
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes.  While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
What are the official names of this protein?
Sec translocon accessory complex subunit YajC.
What is the protein family that this protein belongs to?
Belongs to the YajC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PURT_PROMA
Sequence: MTIFPKTLMLLGSGELGKEVAIAGKRLGCKVIACDRYEEAPAMQVADLAIVLDMNNHNSLQKTIRDYKPDVVIPEIEALAVEALKDIEKEGINVIPNARATAITMNRDQIRNLAAEKLAIKTANYGYASNIEELKEVSKKVGFPLLVKPVMSSSGKGQSLIKDKNDLEKAWDLAIKEARGDSKQVIIEEYINFDLEITLLTIKQSNHQTIFCPPIGHEQKGGDYQCSWQPQKLSFDQLKEAKSIAKKVTNELGGIGLFGVEFFIRGEEVIFSELSPRPHDTGLVTLISQNLNEFELHLRAILGLPIPSIECVSPSASRVILSQESFAKVAYKGIEKALEIQNSKIMIFGKPNTKKGRRMGVSLAQGKTLEEARFKADKSAKCIQIFEAKEAQS
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: IXTPA_RHOBA
Sequence: MNRMFDLVLGTGNAKKLVELRMMLPEETIALTALSEIENAIDVVEDGETFSANAAKKATEQAKHLERWVLAEDSGLSVDALKGAPGVYSARYAGTHGDDEANNEKLLRELTDVPMDRRGAQFNCHLCLSDPDGNVRLAESGICRGRIATERSGGAGFGYDPLFVIPEYHKTFGELNLTVKRALSHRSRALRLFIPQLLRLVQSNSTSA
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: MED26_DICDI
Sequence: MIIKKKKDWRTQLFNRSQKKTIERMRKERNNQSVEMDSHTFNNNNNNNNNNNINNNNNINNNNNNNNNNNNNNNSINNYGHQHLNSSSSSQSFQDQLVQDLQSILMAQQHNIISPQLQQQQQQQQQQQPSFNSNNNNNNNTNTYNFQPEAIENNNIGINSNGYNPIQQQFQQQHQLQQQIQQQQIQFQNQNQNQQTHQNRQLQQQQQHQIQQLQLQQQLQQQLQQQQQHQQQLQQQMQHQQMQQQQIPHHQQNQQLQQQQQQQVPHQQQNQLIQQQQQQQQQQQQQQQHQQHQQHQQHQQQHQQHQQQHQQHQQQHQHQHQQQHQQQQQPQNQQQQQPQNQQMQQQQQQNQQMQQQQQQNQQMQQQMQQQQQLQQQQQILQQQQQIQQQQQQQQQILQPQQQPQQQQQQQQLLQQQQQQQLMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQIQQQQPQQQPQQQQQPQQQQSQQQPQPQQQQQQQQQQQQQQQQIQQQYVDDNGDNTLLIFISNMCRNVEIPAFSVQPDQYYQYFVEKIVVIWSDLISSSGSTKMTHEETQQQKSSLFEQCRRIIVTYPHFFNQIITERFIFDLEDLNSKISDIFKQFNNNNNNNNNNAIENSPIMAEQYKRFQTDYIIKFDQLQCFKFPDYSLSSIISTLNPSPLRQQQQQQQQQQQQQQQQQQQQQQQQQQQIQIQNQTIPIPPSPQPTQQYQPITQLDQQPQPQPQPQLQQQLQQTILDNNNNNNTNNTNNTNTINNNLDISNDIINSSNNIGLCSSPISLENEKGNNNNNNNKINNNNNTSSSSSITIPINNTTSSPINKNINDDINNNNNNNNSNNNNNNNNNNNNNNNNNNTNTNNEIKKTNNDISTNLSMPTVVDLNSSNNITSSTFLLNPNINNNNNNNSSGGGGSSSSSNSNSSSPNIPNKPKKPVKSNSKKVIDLLEDNDSDSSDSSDSSDSSDSSDSSDSSDSDSSDSSDSSDSSDDEKKKKPKKPIVNKKNLVKTNTSTNSKDSKPASTATSTTTTTTNSKPSITQPTSKIKPSSTIPSQPTSITTKKKPENSTTSLPASTSSSSPSNTVIKSSPPISKTLPTPTSTTSLSSSSSATVNKPIPPTTKKPISTINNNTLNNNTNSSINKIASNSTSTLGNKNLGTPSNYNNNNNNIGAEKKKEKALTLTESQLTNEKELPSLTDYIAQLNKIKKSNTTSGVTNSNNNNNNNNNNNNNNNNNNNNNNNNNKGTTTSTTTVINDPNKKKISWKDEKGGCSVVDRVPMFIQEFSECVTWPRIREFLIVIDSKMSNACKKRFLELGGLANIHTVLKYSQETVTIPRDTIIALKGLKGLPVTVEHLHAEKLIGKTIRSFKKHSNPNVKEYAEELESEWMYLIKGGATSNTSSTTSSASSSSSSSISNGNNSDKKRNRDQPITDTSKKLKSSSSSSSSSSSSSSSTNARSSSPVPNTQLPPKKSIIKEYDDLFMNKLSTPSSSSSSSSSSSSSSTTTTTTSTGSTIPLSPPPSSSSSSNNNNSLSPIMTFKTKQSIAAAAAKKQQTQELSDSTAKSLSSNGATTKLFAAMVDKKSQTKPGGGSGGSSNVSGKSDSSQTLLESIGISWDTPTKEEEDLTPVPDPNRRKSSKGKVSVKWLSDEKLVNVKEFCKEEIADAKANEEYELEQSKRFELETERLLGFKPMKATLEWKKPIPIEDTQLPDIKLYGSESLEKDIQFERENFTLMEFYIGSNIPDTPKEPDDEQKDYDDKDVLIIPSGDINDVFDDSKINELMNVIPPILSDQINDDNIINNNNNTHSNSPDENNTKMINDENNDPNNTGSSNKVVEMIANIDPNNNNNNNNINNNNNIINNINNNNNNNMNNNNMGNMNNMGNMNNQFNNMNNNNNNNQFNNGYNNNNNNNNNNNNNNNNNNNNMMGYNNGYNMNNGNQFNNNYNGVYQNNGFNNFNNQYNNGQYNGYNNSNGQFNNNNNNVYNNNNNNQFNNNFNQYNNNNNNNFNQNFNNGFNNNNNNNNQYNNGYNNFNNNNNYGNMNNYNNNNNNYYNNNNNNNNNNNNNQSYS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 26, Putative mediator complex subunit 26.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 26 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LSP1_YEAST
Sequence: MHRTYSLRNQRAPTAAELQAPPPPPSSTKSKFFGKASIASSFRKNAAGNFGPELARKLSQLVKTEKGVLRAMEVVASERREAAKQLSLWGADNDDDVSDVTDKLGVLIYELGELQDQFIDKYDQYRVTLKSIRNIEASVQPSRDRKEKITDEIAHLKYKDPQSTKIPVLEQELVRAEAESLVAEAQLSNITREKLKAAYSYMFDSLRELSEKFALIAGYGKALLELLDDSPVTPGEARPAYDGYEASRQIIMDAESALESWTLDMAAVKPTLSFHQTVDDVYEDEDGEEEEEPEIQNGDIPGQVVEEEEVEWTTEVPVDDEAHEADHHVSQNGHTSGSENI
What is the function of this protein?
Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis.  Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway.  Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.
What are the official names of this protein?
Sphingolipid long chain base-responsive protein LSP1.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Protein: YQEH_ECOLI
Sequence: MGLCSRYKSLTCNSCSMHCQIMPEESPRLQYCANSCFCMWPEESSYFNRGVVEGILTKNHNARLSGYIFVDFSVSFLRLFLEKDWIDYLASTDMGIVLVSDRNMQSLANYWRKHNSAISAVIYNDDGLDVANEKIRQLFIGRYLSFTGGNTLTQMEFTIMGYMVSGYNPYQIAEVLDMDIRSIYAYKQRIEKRMGGKINELFIRSHSVQH
What are the official names of this protein?
Uncharacterized protein YqeH.
What is the protein family that this protein belongs to?
To E.coli YkgK.
Protein: TFE_SULIA
Sequence: MVNAEDLFINLAKSLLGDDVIDVLRVLLEKGTEMTDEEIANQLNIKVNDVRKKLNLLEEQGFVSYRKTRDKDSGWFIYYWKPNIDQINEILLNRKRLILDKLKSRLEYEKNNTFFICPQDNSRYSFEEAFENEFKCLKCGSQLTYYDTEKIKSFLEQKIRQIEEEIDKETKLGANKSH
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: B2MG_CEBOL
Sequence: MARFVVAALLVLLCLSGLEAIQHAPKIQVYSRHPAENGKPNFLNCYVSGFHPSDIEVDLLKNGKKIEKVEHSDLSFSKDWSFYLLYYTEFTPNEKDEYACRVSHVTFPTPKTVKWDRNM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYK_MOOTA
Sequence: MKLEAENDLMAVRLEKLHQLQEAGIEPYGGPFEVTHSTTAIRERFDELEGQEVALAGRLLAIRSHGKASFADLQDREGRLQLYIRLDNVGPGIYELFQKLDIGDIVGVRGKVFRTHRGEISVEVRQLTLLCKSLRPLPEKWHGLKDVDLRYRQRYLDLIVNPEVKQVFITRARIIRAIRSFLDNRGFLEVETPTMHPIAGGAAARPFITHHNALDIDLYLRIALELHLKRLLVGGLEKVYEMGRIFRNEGISTKHNPEFTMLELYQAYADYYVMMDLLEEMVAYVAREALGTTVVTYQGDRLDLTPPWPRLTMLEAIKKYYGVDFDQLPTAEDARRAAISLGLEIEPGMERGKIINEVFEATVEPHLIQPTFILDYPVAISPLAKRKKENPDFTYRFEAFIAGRELANAFSELNDPIDQRRRFEAQMAERAAGDEEAHMMDEDFLQALEYGMPPAGGMGIGIDRLVMVLTDSPSIRDVILFPTMRPKEE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATP_HAEI8
Sequence: MKYQKLENQESNWKWIYLIRKHREGENITRYEERSLQEAKAQELLESQNYPSQIEEWIKNHLSPALPIKLDQAIRARRKRFFNGEKQHTKKKSIDLEYAVWLRLSKYSRKMKMTLSETITYMIDERESKAQFENQMAAMKTSLKNLLK
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_DEIRA
Sequence: MTFARSSRSGLQDTIAAVATAPGSAGVGIVRVSGPRALEIADGLFRGKRRPSATPGGRFLFGELHADEELLDEGLCLVFRGPRSYTGEDVAEVQTHGSPAVLSRVLARTLDLGARLARPGEFTLRAYLAGRLDLTQAEAVLGLVEASTETARRQSALGLSGALSERVAGVARALTRTLAAIQALLDYPEEGVPDEDRAAPLLGAQSALEELLASAHAGRISTRGARLALIGRPNAGKSSLLNALLGYERSIVTPLPGTTRDYLEAGLELAGVPVTLVDTAGLRETEDLIEAAGVRQAVALAGNADLVLVLEDGSQPREPLPTELPPTATVLRLRTKADLPAAWTDPAALDVSAVTGAGLPALREAIGAALLGDATRGEAWLTTERQTDTVRRALTHVQAARTLPDDLAGYELEEALHALAELTGQDVQEDVVDAVFRNFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_BRUA4
Sequence: MTAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMAKGDLHIDDHHTVEDTGIALGQAIAKALGERRGIVRYASMDLAMDDTLTGAAVDVSGRAFLVWNVNFTTSKIGTFDTELVREFFQAFAMNAGITLHINNHYGANNHHIAESIFKAVARVLRTALETDPRQKDAIPSTKGSLKG
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.