PharMolix/UniProtQA huggingface dataset:
Protein: NORM_BACC1
Sequence: MKETSTFSQKLKQFVLLFFPIFITQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVGSKKKEDVPQVVIQAVYLAICASFVVMLIGFFAVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKTRTTMIITLLSLPINVILNYVLIFGHFGFPKLGGVGAAIASTATYWCILIITVMIIRTKEPFASFHIFKQLYRPSLSSWKEFLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVSLIMTLIAYWVIGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTIENRRSR
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNTA_SYNY3
Sequence: MAATLSRLDISVDGVSVTYNNARLALYNATCTVEPGTITALVGPNGSGKSTLFKSIMGFLQPSQGRVRIGGFSVQKAQKQQLMAYVPQADEVDWNFPVSVFDVVMMGRYGYMNVLRIPSAKDRRLVMESLERVGMVKYRDRQIGELSGGQKKRAFLARALAQEGKVILLDEPFTGVDVKTEKGMIDLLMELRDEGHTILISTHDLASISTFCDHTILLNRTILAQGKTEETFTKENLELTFGGLPMLSLNQMFESTEVDA
What is the function of this protein?
Part of an ATP-driven transport system for manganese.
What are the official names of this protein?
Manganese transport system ATP-binding protein MntA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: PELO_METLZ
Sequence: MKAELPEPLKKDGFGEYKLMPESIDDLWHLSHLISPGNTVYAVTLRTVDGPSDKLRSEKLEKRPVRIGVKCEKAEFVPESSRLRVFGVISYGPDMGQHHTLNIEAGYEISVVRQWRQIDLARLERAVSSSVHGVVHIAAIEDGEAELYRVRQYGPERITTLTVGSGKTAELDSRQALFAELLTFLEKVTGSIVIAGPGFVKEDFVKFAKTKAPEIAERMLIADTRRCGYGAVQEAIGNGVLTRVAEDLQLAKEVSFMDEVFLRIGQNGAVAYGKSEVRQAIDYGAAETILVADSFVKDGGIEKMIEGAERLGANVVVLSTEFEPGTRLVGLGGVAALLRYKI
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_ENT38
Sequence: MALQQEIIQALGVKPSIDANAEIRRSIDFLKSYLKTNSFLKTLVLGISGGQDSTLAGKLCQQAISELRQETGDESLQFIAVRLPYGVQADEQDCQDAIAFIHPDRVLTVNIKGSVLASEQALREAGLELSDFVRGNEKARERMKAQYSIAGMTKGVVVGTDHAAEAVTGFFTKYGDGGTDINPLFRLNKRQGKQLLAALGCPEHLYLKAPTADLEDDRPSLPDEAALGVTYENIDDYLEGKTLDDTIARTIEGWYLKTEHKRRPPITVFDDFWKR
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: NDK_ACIB5
Sequence: MAIERTLSIVKPDAVSKNHIGEIFARFEKAGLKIVATKMKHLSQADAEGFYAEHKERGFFGDLVAFMTSGPVVVSVLEGENAVLAHREILGATNPKEAAPGTIRADFAVSIDENAAHGSDSVASAEREIAYFFADNEICPRTR
What is the function of this protein?
(Microbial infection) Catalyzes the phosphorylation of dZDP to dZTP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4029_BURVG
Sequence: MTPSEFRRSVRSGAFRGPTAGQCGPFAQANLAILPNAHAHDFLRFCHANPKACPLLGVGEPGAFRVDVLGADLDVRTDVPSYNVYRDGRLTERVDSLEALWRDDFVVFAIGCSFSFEDMLAREGIALRHIEEGRNVPMYRTSIPNRRAGIFGGQLVVSMRPLRGADAIRAVQITSRFPGVHGAPIHIGHPRALGIADLGAPDFGDAVTVRDDELPVFWACGVTPQTALMEAKLPLAIAHTPGYMLITDMTNASLAVF
What are the official names of this protein?
Putative hydro-lyase Bcep1808_4029.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: CHS1_RHIAT
Sequence: EFLFARTMIGVFKNIEYMCNRTSSKTWGKEAWKKIVVCIVSDRRAKINPRTRAVLAGLGVYQDGIAKQQVNGKDVTAHIYEYTTQVGLELKGTQVSLKPRSATPVQLLFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLIDAGTKPGKDSIYQLWKAFDLEPMCGGACGEIKVMLDHGKKLYNPLIAT
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 1, Chitin-UDP acetyl-glucosaminyl transferase 1, Class-I chitin synthase 1.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family. Class I subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BXA6_BOMMO
Sequence: MKILLAIALMLSTVMWVSTQQPQAVHTYCGRHLARTLADLCWEAGVDKRSGAQFASYGSAWLMPYSEGRGKRGIVDECCLRPCSVDVLLSYC
What is the function of this protein?
Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
What are the official names of this protein?
Bombyxin A-6, BBX-A6, 4K-prothoracicotropic hormone, 4K-PTTH, Bombyxin-II.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MTNA_HALHL
Sequence: MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVAAGYGAALAGAAAWRTHGSGWQAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQDPAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTHCNTGSLATGGLGTALGVIRTAWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGADRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLYAGGRRIAPESEAVGAWNPVFDVTPAELVDVIVTERGVVHQPDADGIARLFEGAG
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: CLYBL_MOUSE
Sequence: MALCVLRNTVRGAAALPRLKASHVVSVYKPRYSSLSNHKYVPRRAVLYVPGNDEKKIRKIPSLKVDCAVLDCEDGVAENKKNEARLRIAKTLEDFDLGTTEKCVRINSVSSGLAEVDLETFLQARVLPSSLMLPKVEGPEEIRWFSDKFSLHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKTGPQVGLCLDAVVFGGEDFRASIGATSNKDTQDILYARQKVVVTAKAFGLQAIDLVYIDFRDEDGLLRQSREAAAMGFTGKQVIHPNQIAVVQEQFTPTPEKIQWAEELIAAFKEHQQLGKGAFTFRGSMIDMPLLKQAQNIVTLATSIKEK
What is the function of this protein?
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341).  Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (By similarity).  The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341).  Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity).  Also displays malyl-CoA thioesterase activity.  Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (By similarity).  Also has very weak citramalate synthase activity in vitro (By similarity).
What are the official names of this protein?
Citramalyl-CoA lyase, mitochondrial, (3S)-malyl-CoA thioesterase, Beta-methylmalate synthase, Citrate lyase subunit beta-like protein, mitochondrial, Citrate lyase beta-like, Malate synthase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HLDE_AZOVD
Sequence: MKLSMPRFDRSPVLVVGDVMLDRYWHGCTTRISPEAPVPVVKVEQMEDRPGGAANVALNIAALGGAATLVGVTGADEAADSLARSLASAGVDVHFQRIASQPTIVKLRVMSRHQQLLRMDFEEPFATDAAALAAEVEGLLAGIRVLVLSDYGKGALKNHQALIQAARARGIAVLADPKGKDFGIYRGADLITPNLAEFENVVGRCADEGELVARGARLMADLELGALLVTRGEHGMTLMRPGHPPLHLPARAREVFDVTGAGDTVISTLAAALAAGEELPQAVALANLAAGIVVGKLGTATISVPELRRAVQREQGSERGVLGLEQLLLAIEDAHAQGEKIVFTNGCFDILHAGHVTYLEQARAQGDRLIVAVNDDASVTRLKGPGRPINTVDRRMAVLAGLGAVDWVISFAEDTPERLLEQIRPDVLVKGGDYGIDQVVGADIVRAHGGEVRVLGLVENSSTTGIVEKIRRQP
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: MTX1_BOVIN
Sequence: MAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSHGEVISVPHRIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLKHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE
What is the function of this protein?
Involved in transport of proteins into the mitochondrion.  Essential for embryonic development (By similarity).
What are the official names of this protein?
Metaxin-1, Mitochondrial outer membrane import complex protein 1.
What is the protein family that this protein belongs to?
Belongs to the metaxin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: TPM_PENAT
Sequence: MDAIKKKMQAMKLEKDNAMDRADTLEQQNKEANNRAEKSEEEVHNLQKRMQQLENDLDQVQESLLKANIQLVEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin Pen a 1.0102, Allergen Pen a 1, Tropomyosin Pen a 1.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: HIS4_ECO5E
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAISCWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y452_MYCGE
Sequence: MLIIFKDLNLVKTNNCQIIGWWKQLSLPQKTFLSFIPLFLVTSAFVLTGIVESLLTFGTIIEQIDKFTDQTNVMLLIYAVIYTFNPKSWLLKNQQFFLSALAYILFTFIGYNLILSIAGIAYKSTNPYKLTSSIFLHVIAPIAFFIASFIKIKHEKDVNINMFFKSLLLFMIYPLIYGLYLVTIPYVRHYLFNGRPSTYTIYGSITNTKNNPFAWLVVFAVLFIYFPLSYLAIYLLQLKLIKKAIQPQFNLPFTLNKWKQK
What are the official names of this protein?
Uncharacterized protein MG452.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFG_SHIDS
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_ANAD2
Sequence: MAKLLAMILAGGEGRRLDPLTRDRAKPAVPFGGRYRIVDFVLSNMANSGILKMKVVVQYKSESLNTHVQRAWRLTSLLNQYVELVPAQMRVGPKWFEGSADAIYQNLNIITDEEPDFTFVFGADHVYRMDARQMLEFHLDRKAELTVAAVPIPVQEASEFGIIEVDADGRMIGFVEKPQSAPKTIPGDPTRCLASMGNYLFSTDALVQEIVRDAGDPSSAHDFGKSIVASMYQRKRVYVYDFARNVVPGQTERERGYWRDVGSIDAYFQANMDLVAVDPVFSLYNDEWPIFTVQYNYPPAKFVFNNESDHRVGRATDSLVSEGCIISGSHVHHSILSPKVRVNSYATVDESIVFENVNIGRHCRIRRAIIDKHVDIPAHTTIGYDHEKDRKHFHVTESGIVIIPKGMRIEAGR
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: HEMA_I77A7
Sequence: QDLPGNDDSTATLCLGHHAVTNGTIVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGRDCTLIDALLGDPHCDVFQDETWDLFVERSNAYSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPANGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTSQEQTTLYVQASGRVIVSTRRSQQTIISNIGSRPWVRGQSGRISIYWTIVKSGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDVWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNADVLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNTCIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: COQ4_CANTT
Sequence: MLRTAIRNNVQVSQKRTYIMSTIASTFLGSILFSKNNQLASKMENGELHMPKDPTLSYLNNNNSNNQAEPYFKRREPDYPGHVPLYNYEKFLMFLGSSIGSFFHPEENKYIVALGESTAIEPILKKLQKTMLSDEIGRQILKEKPRITSTSLNLDYLRSLPDNTIGKNYINWLDKEGVSPDTRVQVKYIDNEELSYIFQRYRECHDFYHAITGLPIIIEGEISVKVFEFMNIGIPMTGLGALFAPLRLKSSQRKRLREIYYPWAIKNGIYSKPLINVYWEKILEQDVDEFRKQMGIETPPDLRNMRKEYFARKKLEKQGKL
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TPM_PSOOV
Sequence: MEAIKKKMQAMKLEKDNAIDRAEIAEQKARDANLRAEKSEEEVRGLQKKIQQIENELDQVQEQLSAANTKLEEKKKALQTAEGDVAALNRRIQLIEEDLERSEERLKIATAKLEEASQSADESERMRKMLEHRSITDEERMDGLENQLKEARMMAEDADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKAQQREEAHEQQIRIMTAKLKEAEARAEFAERSVQKLQKEVDRLEDELVHEKEKYKSISDELDQTFAELTGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin, PoTRO.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: ACSL5_HUMAN
Sequence: MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVSQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQD
What is the function of this protein?
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490).  ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity).  Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity).  It was suggested that it may also stimulate fatty acid oxidation (By similarity).  At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL.  May have a role in the survival of glioma cells.
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 5, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.
Protein: ACCD_DESHD
Sequence: MLKDIFRKKRKYATLSSLPPKNSEGGLAYFDEPSPEQESTRKELPDGLWVKCPKCGEALFNKDLVENQRVCLTCSYHFRIPARERLEHLVDPGSFAEWDRELQTTNPLSFPDYEEKLAEAYQKSDVSESVLTGQASIEGMPVVLAFNEGNFMMGSMGSVTGEKITRAIERAIELRCPVIIFSTSGGARMQEGILSLYQMAKTSAALGRLAEEGLLYISVLTDPTFGGVTASYASLGDIHIAEPGALIGFTGPRVIKQTMRKELPEGAQTAEFNQSHGQIDCVVERAEMRKVLGRLLRYHQEGAV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALL5_LEPDS
Sequence: DDFRNEFDRLLIHMTEEQFAKLEQALAHLSHQVTELEKSKSKELKAQILREISIGLDFIDSAKGHFERELKRADLNLAEKFNFESALSTGAVLHKDLTALATKVKAIETK
What are the official names of this protein?
Mite allergen Lep d 5.
What is the protein family that this protein belongs to?
Belongs to the mite group 5 allergen family.
Protein: DRTS2_ARATH
Sequence: MRCLQNSAKTLPLAFKSALLPLSQRWFCKFSPKPSSLTNIFKVSISTMANTLNGNVIMTSKPQSTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDLTLSTSDSAKKNAVVMGRKTWESIPKKYRPLSGRLNVVLSRSSGFDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGDILREALNKPSCEAIHITEIDTSIDCDTFIPTVDTSAYQPWCSSFPICENGLRFSFTTHVRVKSSSAGEASDESDGSKVLQVDWKKFSSVLPKMIFDRHEEYLYLNLVKEIISNGNLKDDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIRIWDGNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILAHVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKKIDMKMAV
What is the function of this protein?
Bifunctional enzyme.  Involved in de novo dTMP biosynthesis.  Key enzyme in folate metabolism.  Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction.  Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
What are the official names of this protein?
Bifunctional dihydrofolate reductase-thymidylate synthase 2, DHFR-TS 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thymidylate synthase family.
Protein: SUMO1_BOVIN
Sequence: MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2.  Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1.  Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  May also regulate a network of genes involved in palate development.  Covalently attached to ZFHX3.
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus. Note=Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity).
Protein: TPC13_RAT
Sequence: MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMKDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQGGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVTELNSVNQAGECVSTFGSRGYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTTSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSAAVEVEA
What are the official names of this protein?
Trafficking protein particle complex subunit 13.
What is the protein family that this protein belongs to?
Belongs to the TRAPPC13 family.