PharMolix/UniProtQA huggingface dataset:
Protein: ERA_BORBZ
Sequence: MKSGFAAILGRPSTGKSTLLNSICGHKISIISPIPQTTRNNIKGIFTDDRGQIIFIDTPGFHLSKKKFNIAMMKNIHSSIGEVELILYIIDIQDKPGEEENKMLEIIKNSKIKFLVILNKIDLKNTKIKEITQFLKEKGIEDSNIIKISAEKKINTEELKNKIYENFSEGPLYYPQEYYTDQEINFRISEIIREKAIENLKEELPYSLYVDIDTLENKKGSLFIRANIFVANESQKGIIVGKNGKEIKSIGERARKTIAKIFETKCNLFLQVKLKKNWNKEDKLIKRLIN
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: PRPE_ECOLI
Sequence: MSFSEFYQRSINEPEQFWAEQARRIDWQTPFTQTLDHSNPPFARWFCEGRTNLCHNAIDRWLEKQPEALALIAVSSETEEERTFTFRQLHDEVNAVASMLRSLGVQRGDRVLVYMPMIAEAHITLLACARIGAIHSVVFGGFASHSVAARIDDAKPVLIVSADAGARGGKIIPYKKLLDDAISQAQHQPRHVLLVDRGLAKMARVSGRDVDFASLRHQHIGARVPVAWLESNETSCILYTSGTTGKPKGVQRDVGGYAVALATSMDTIFGGKAGSVFFCASDIGWVVGHSYIVYAPLLAGMATIVYEGLPTWPDCGVWWTIVEKYQVSRMFSAPTAIRVLKKFPTAEIRKHDLSSLEVLYLAGEPLDEPTASWVSNTLDVPVIDNYWQTESGWPIMAIARGLDDRPTRLGSPGVPMYGYNVQLLNEVTGEPCGVNEKGMLVVEGPLPPGCIQTIWGDDGRFVKTYWSLFSRPVYATFDWGIRDADGYHFILGRTDDVINVAGHRLGTREIEESISSHPGVAEVAVVGVKDALKGQVAVAFVIPKESDSLEDRDVAHSQEKAIMALVDSQIGNFGRPAHVWFVSQLPKTRSGKMLRRTIQAICEGRDPGDLTTIDDPASLDQIRQAMEE
What is the function of this protein?
Catalyzes the synthesis of propionyl-CoA from propionate and CoA.  Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity).
What are the official names of this protein?
Propionate--CoA ligase, Propionyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: TATD_ERWBE
Sequence: MFDIGVNLTSTQFAKDRDQVVKRAKDAGITGLLITGTNALESQQAQSLATRRPGYCWSTAGVHPHHASEWSGETAATLKRLAESPEVVAIGECGLDFNRNISEPEQQVYAFNAQLELAAELAMPVFLHCRDAHDRFLAVLTPWLPTLPGAVVHCFTGTREELEACLAAGLSIGITGWVCDERRGVELRELMPLIPADRLLLETDAPYLLPRDMRPRPPSRRNEPCFLPHIVQVVAGLRGEEPEALGRQCDANARKLFRLPA
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTB_PSEF5
Sequence: MKSYEVNFDGLVGPTHNYGGLSYGNVASQSNSQQGSNPREAALQGLAKMKALMEMGFQQGVLAPQERPDVAALRNLGFAGTDAQVIQQAAKQAMPLLVASCSASSMWVANAATVSPSADTADGRVHFTAANLNCKYHRSIEHPTTSRVLGAMFADQKHFAHHAALPAVAQFGDEGAANHTRFCRDYGQAGVEFFVFGRSAFDTRYPAPQKYPARQTLEASQAVARLHGLSEEGVVYAQQNPSVIDQGVFHNDVIAVGNGEVLFYHEDAFLETDKMLAELQGKLGKRGGNFQSICVPRSQVTVEDAVRSYLFNSQLLSRADGSMLLIVPEECRGNERVWQYLQSLTSSGGLIREVKVFDLKQSMQNGGGPACLRLRVALKETELAAVNPGVIMTAPLYDTLTQWVGKHYRDRLSESDLADPQLLLECRTALDELTQILKLGAVYPFQIN
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: DNLJ_STRA1
Sequence: MENRMNELVSLLNQYAKEYYTQDNPTVSDSQYDQLYRELVELEKQHPENILPNSPTHRVGGLVLEGFEKYQHEYPLYSLQDAFSKEELIAFDKRVKAEFPTAAYMAELKIDGLSVSLTYVNGVLQVGATRGDGNIGENITENLKRVHDIPLHLDQSLDITVRGECYLPKESFEAINIEKRANGEQEFANPRNAAAGTLRQLNTGIVAKRKLATFLYQEASPTQKETQDDVLKELESYGFSVNHHRLISSSMEKIWDFIQTIEKDRVSLPYDIDGIVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVVVYKAGDIIPAVLNVVMSKRNQQEVMLIPKLCPSCGSELVHFEGEVALRCINPLCPNQIKERLAHFASRDAMNITGFGPSLVEKLFDAHLIADVADIYRLSIENLLTLDGIKEKSATKIYHAIQSSKENSAEKLLFGLGIRHVGSKASRLLLEEFGNLRQLSQASQESIASIDGLGGVIAKSLHTFFEKEEVDKLLEELTSYNVNFNYLGKRVSTDAQLSGLTVVLTGKLEKMTRNEAKEKLQNLGAKVTGSVSKKTDLIVAGSDAGSKLTKAQDLGITIQDEDWLLNL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: BIOB_ANASK
Sequence: MCETASTTLPPGITPISGDEARRLIHHTSGPELEALLDRAEAVRRAVHGDEVALCGITNAKSGRCPEDCGFCSQSARFEGADAPVYPMIGAGEIVEQAHKAERAGAREFSIVASGTRLAREQELATVEEALRRLRAETAVEPCASLGLMREPELRRLKDAGLMHYHHNLETARSHFENVCTTHTFDEQLETIRAAKGLGLKLCSGGILGMGETPEQRVEFAEEVRDLGVDCVPVNFLNPRAGTPLAHLKAITPEECLAALAVFRLMMPAAHIFVMGGREVNLGDRQDLIFRAGANGTMVGNYLTSAGRAPDLTVGMVERQGLTLRPPDTGKPWAFDGHAPSDADWNRKAAEPRPRPLPVVR
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MDH_BACC3
Sequence: MTIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANIIGTSDYADTADSDVVVITAGIARKPGMSRDDLVATNSKIMKSITRDIAKHSPNAIIVVLTNPVDAMTYSVFKEAGFPKERVIGQSGVLDTARFRTFIAQELNLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGSAYYAPAASLVEMTEAILKDQRRVLPAIAYLEGEYGYSDLYLGVPVILGGNGIEKIIELELLADEKEALDRSVESVRNVMKVLV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: O51T1_HUMAN
Sequence: MAIFNNTTSSSSNFLLTAFPGLECAHVWISIPVCCLYTIALLGNSMIFLVIITKRRLHKPMYYFLSMLAAVDLCLTITTLPTVLGVLWFHAREISFKACFIQMFFVHAFSLLESSVLVAMAFDRFVAICNPLNYATILTDRMVLVIGLVICIRPAVFLLPLLVAINTVSFHGGHELSHPFCYHPEVIKYTYSKPWISSFWGLFLQLYLNGTDVLFILFSYVLILRTVLGIVARKKQQKALSTCVCHICAVTIFYVPLISLSLAHRLFHSTPRVLCSTLANIYLLLPPVLNPIIYSLKTKTIRQAMFQLLQSKGSWGFNVRGLRGRWD
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 51T1, Olfactory receptor OR11-26.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PGP_HALLT
Sequence: MVPPLALDIDGTLTTASGRLDARVFELLPDWDAPVVLATGKAFPYPVALAHFLGRAETVIAENGGVVHVDGETAILGDAEAPRAVVEAFRERGGDPGWGARDTVNRWRETEVALSLDADEALLREVAAAAGGDVEVVDTGYAYHVKSTGVSKGRGLERVGDALGIGPDEFVAIGDSENDVSTFAVAGESYAVANADGAAREAADIVVADSYMDGTAGVLADLRTRTE
What is the function of this protein?
Catalyzes the dephosphorylation of 2-phosphoglycolate.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the archaeal SPP-like hydrolase family.
Protein: YHHX_ECOLI
Sequence: MVINCAFIGFGKSTTRYHLPYVLNRKDSWHVAHIFRRHAKPEEQAPIYSHIHFTSDLDEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLVEKPFTPTLAQAKELFALAKSKGLTVTPYQNRRFDSCFLTAKKAIESGKLGEIVEVESHFDYYRPVAETKPGLPQDGAFYGLGVHTMDQIISLFGRPDHVAYDIRSLRNKANPDDTFEAQLFYGDLKAIVKTSHLVKIDYPKFIVHGKKGSFIKYGIDQQETSLKANIMPGEPGFAADDSVGVLEYVNDEGVTVREEMKPEMGDYGRVYDALYQTITHGAPNYVKESEVLTNLEILERGFEQASPSTVTLAK
What are the official names of this protein?
Uncharacterized oxidoreductase YhhX.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
Protein: TRMN6_SHIDS
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLACAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPKAGECFSDRLIIRGSDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_SALA4
Sequence: MSHPALTRLRALRYFDAIPALEPHLLDWLLLEDSMTKRFEQQGKRVSVTLIREAFVGQSEVEEASGLLPSESRYWLREILLCADGEPWLAGRTVVPESTLCGPEQVLQHLGKTPLGRYLFTSSTLTRDFIEIGRDATLWGRRSRLRLSGKPLLLTELFLPASPLY
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_TREPA
Sequence: MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALARAHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLASPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDATAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAEYAAGMIPPFRAALYADLDGRAAGDVPH
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CHT_MICSH
Sequence: MPINKYKAAVVTSEPVWENLEGGVVKTIEFINEAGKAGCKLIAFPEVWIPGYPYWMWKVNYLQSLPMLKAYRENSIAMDSSEMRRIRAAARDNQIYVSIGVSEIDHATLYLTQVLISPLGDVINHRRKIKPTHVEKLVYGDGSGDSFEPVTQTEIGRLGQLNCWENMNPFLKSLAVARGEQIHVAAWPVYPDLSKQVHPDPATNYADPASDLVTPAYAIETGTWVLAPFQRISVEGLKRHTPPGVEPETDATPYNGHARIFRPDGSLYAKPAVDFDGLMYVDIDLNESHLTKALADFAGHYMRPDLIRLLVDTRRKELVTEVGGGDNGGIQSYSTMARLGLDRPLEEEDYRQGTDAGETEKASSNGHA
What is the function of this protein?
Catalyzes the hydration of cyanide to formamide.  Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.
What are the official names of this protein?
Cyanide hydratase, CHT, Cyanide-degrading nitrilase, Formamide hydrolyase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: DNLJ_SYNR3
Sequence: MAFTAQQQLRAAELRQLLNRAAHAYYVLDAPEFEDAVYDRLYRELLDLEQQHPDLLSADSPTQRVGGPPAEGFSSVEHRIGMLSLDNAFNAEELQAWDARLGRQLEDNPERQREYVCELKIDGNALALSYADGVLVRAATRGDGSRGEEITANVRTIQAVPLRLQLKQPPAWVEVRGEAFIPDDTFEAINAERQQRGEALFANPRNACAGTLRQLDPKAVAARRLDFFAYTVHLPADEMGPKSQWDALQWLETAGFRVNPHRERTSGADGVVAFYDRWEEQRHQLPYATDGVVVKLDALERQQLAGFTQKAPRWAIALKYAAEEAPSRLLRLVAQVGRTGVVTPVAEFEAVPLAGTSVSRATLHNADRLEELDLHSGDTIVVRKAGEIIPEVLRVLPELRPEGAEQLELPSHCPECGSLLVRESGEAATRCVNSSCPAILRGALRHWVSRQAMDVDGLGGKLIEQLVDRGLVRSIADLYRLDAALLASLERMGEQSASNLIEALAASRQRPWHRLLYALGIHHIGSVNAKTLAAAFPSWEALQSASEEALNELYGIGPEISQSMQQWCSTEANQSLMAELAALELPLASDDSSAESAGAIGALTGQTLVLTGTLPNLSRLEAQALIEAAGGKVTGSVSKKTNYVVAGSEAGSKLQKAEKLGVAVIDEAELKALLS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NOCM_AGRFC
Sequence: MDIQLIIESFPKLLAAVPTTLTLAFISLLIGFVVSVPVALMRLSKNRIVSSLAYGYVYIIRSTPLLVQMFLIYYGSAQFRGVLSEVGLWSSFREPWFCAILALALNTAAYTSEIIRGGIQSVSLGQIEAARAVGMSTFLQFRRIVFPIAIRQALPAYGNEVMLIIKSTSLASTITIVEVTGLAKQIISATYSPVEVFIVAGAIYLFITFVVSRLVMLAEWWLNPHMRARVGGTAPKAAETH
What is the function of this protein?
Component of the nopaline active transport system probably consisting of four subunits: Q, M, P and T.  This system is also capable of transporting octopine provided that catabolic functions are induced with nopaline.
What are the official names of this protein?
Nopaline transport system permease protein NocM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYIA_MAGGR
Sequence: MASQDGTTELLSQSVNSTCIPGSTYHVDRGRASSASTPPTSPPLSEVDYTPLLESTQEPRHEYTQLAHSLVKAMADYVGHLQEENLPMPSLEPAAQVHGGLKVQGGVAARDTVVKLAQKIVAMTMDPEMKLFISSLQFHFCSSLKVAIDLRVHELDECFRASSRQADALALARYREPHEADTLGFGLAFNTTANFWEVLARDTEGKRSQRFNRAMRAVNINALEVIPRIYPFNRIGGNGLLVDVGGGLGQVARAIMATNQGSRLQRCIVQDVCAADDVLEEVLESNRKLGVELQRHDFFDKQPVTGASIYFFRHIFHDWPDRACVKILKQIVQAMGRDSRLLICDQVVDDEPSIPATLYDIDMWTLFGGKERNRSEWEALFRAADERLYIKKVWTTTEAPTTILEVCLW
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology (PubMed:31099577) (Probable).  Pyrichalasin H is indicated as the responsible agent for the genus-specific pathogenicity of M. grisea toward crabgrass (PubMed:31099577).  The first step in the pathway is catalyzed by the O-methyltransferase pyiA which methylates free tyrosine to generate the precursor O-methyltyrosine (PubMed:31099577).  The hybrid PKS-NRPS pyiS, assisted by the enoyl reductase pyiC, are responsible for fusion of the O-methyltyrosine precursor and the polyketide backbone (PubMed:31099577).  The polyketide synthase module (PKS) of pyiS is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the O-methyltyrosine precursor (PubMed:31099577).  As the NRPS A-domain demonstrates substrate tolerance, pyiS can also use phenylalanine, tyrosine and even para-chlorophenylalanine as amino acid precursor, which leads to the production of novel cytochalasans, including halogenated cytochalasans (PubMed:31099577).  Because pyiS lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase pyiC (PubMed:31099577).  Reduction by the hydrolyase pyiE leads to 1,5-dihydropyrrolone, which is substrate for dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase pyiF to yield the required isoindolone-fused macrocycle (PubMed:32039410).  The tailoring cytochrome P450 monooxygenases piyD and piyG catalyze the hydroxylation at C-18 and C-7, respectivily, whereas the short-chain dehydrogenase/reductase pyiH reduces the carbonyl at C-21 in preparation for the transfer of an acetyl group by the acetyltransferase pyiB (PubMed:31099577).  These 3 reactions whose order is not clear yet, lead to the production of O-methylpyrichalasin J, a deacetylated pyrichalasin H (PubMed:31099577).  Finally, pyiB to converts O-methylpyrichalasin J into the final product pyrichalasin H via acetylation of C-21 (PubMed:31099577).
What are the official names of this protein?
O-methyltransferase pyiA, Pyrichalasin H biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: PLP_RICFE
Sequence: MKKLSVIFLSVSMLSGIAFADKDKVVATYKGGEVKESQIMKEFKPQLNLQSGETIKNFDDFPPQDQEKLIKIYVNNLLLKEEVAKSNITSSKEFQEKLENAKNQLAQQELLANYIKSNITDKMFDDEYNKYVGNLKGKEQIKVAHILVKSQKEANNIKTKLSKGGNFTKLAEESSLDKASASNGGVIGYILLNQPGQLVPEFEKKAFALKVNEVSTPVKTDFGWHIIKVLEKKPVPIPTKEEAKVTIDNILAAEVLKKYISDLEAKADLKIMLPKAGSKAGS
What are the official names of this protein?
Parvulin-like PPIase, Peptidyl-prolyl cis-trans isomerase plp, Rotamase plp.
What is the protein family that this protein belongs to?
Belongs to the PpiC/parvulin rotamase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PDXY_SALTI
Sequence: MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIGQLAHCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNVNDAVQAARELIAQGPEIVLVKHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Putative pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: MATK_ALLCA
Sequence: MEAIQRYLQFDRSQQLSFLYPLIFQEYIYAFARDHSLNRAILLENPGYDNKSSFLIVKRLITRMYQQNHFIISANDSSQNPFFGRNKNLYSKMISEGFSFIIEIPLSTRLISSEELKGILKSPNLRSIHSIFPFLEDNFSHFHFVLDILIPHPVHLEILFQTLRYWLKDAPSLHLLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLWFHSERVYIKQLSNHSLDFMGYFSIVRLNPSMVRSQMLENXFLINNAIKKFDTLVPMIPLIGSLSKAKFCNLFGHPISKSARTDLSDSDIMDRFGRICRNLSHYHSGSSKKKSLYRIKYILRLSCAKTLARKHKSTVRAFLKRLGSEFFEEFLMSEEETLCLTFPRVSSPFWGVYGSRIWYLDITCINDLANQQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL36_MYCSS
Sequence: MKVNPSVKPICDKCRVIRRHGRVMVICSDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: TOS3_YEAST
Sequence: MVLLKEPVQPLPRSSLLYNNASNSSSRIKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFMCHYGKSDAASVLTNLETFHELKVSPPSSCKRVELVSLPVNSSFASLDSVYMENFDHNNLRTGADRNSTYSPSIYDANTLSPSAYHNIGSRESSYSSFSSFTSSTAFASQISIQDAPAIGDQQCLIGESGSSLRVNSCEFPQYTTMSPVGEYPFESTEASLSSTLTPVGNVPQRIKAHLVEGKSNSKDDLRIEADASLVFEASDAQRTRRRMSLYKL
What is the function of this protein?
One of the three SNF1 protein kinases (with SAK1 and ELM1) which are required for growth on nonfermentable carbon sources and nonpreferred sugars and for response to environmental stress.  Activates SNF1 by phosphorylation of its activation-loop 'Thr-210'.  Required for the regulation by SNF1 of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.  Phosphorylates also GAL83, MIG1 and SIP2.
What are the official names of this protein?
Serine/threonine-protein kinase TOS3, Target of SBF protein 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: SUWA_DROME
Sequence: MLPYNVRNAGGGSVGGILRRTGQGSGTGSTILGNGNSPGALGAGKVSSSLENHRQPPLELLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAPPGGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEELRLRQEEDLKRLQQETSGGCFSQVGFQYDGQSAASTSIGGSSTATSQLSPNSEESELPFVLPYTLMMAPPLDMQLPETMKQHAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIKAAKFPPAPQTPLDQQNTDKEAPSADDHSEEVAGGRRNPNQVVITVPTIKYKPSANCAYTQLISKIKGVPLQAVLQEDESSNPGNSQHSGGTASPALSCRSEGHNSQGGEFTPVLLQYNGSTFTHEEESSNREQQDDNDVNGGEPPQVELLKNTSALALAQNYSSESEEEEDQVQPEKEEEKKPEPVLTFPVPKDSLRHIIDKTATYVIKNGRQFEETLRTKSVDRFSFLLPANEYYPYYLYKVTGDVDAASKEEKTRKAAAVAAALMSKKGLSFGGAAAAVSGSNLDKAPVSFSIRARDDQCPLQHTLPQEASDEETSSNAAGVEHVRPGMPDSVQRAIKQVETQLLARTAGQKGNITASPSCSSPQKEQRQAEERVKDKLAQIAREKLNGMISREKQLQLERKRKALAFLNQIKGEGAIVGSAVPVVGPNPPESAAGAATADSGDESGDSVRSIPITYFGPDDDDEVGEQRPEMRLIGSTQKDEEDDDEEDGGDLEKYNLLNDDSTNTFTSKPVLPPTAAPPPAAVLLSDDDDVQLVATTSTRSSSSRHLKTHRRSRSRSKNVRSSDSSPSSRESSRRRRQKSSRLSREPSSNPPRKSQHSSTQRKKTPKKRRRSKSRSRSKSIRRSRSISILRNNRRSRSRSPSCRNAEQRRQQDRRRTPTKKSHKRHKRRRRSSSP
What is the function of this protein?
Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events).  Regulates its own expression at the level of RNA processing.
What are the official names of this protein?
Protein suppressor of white apricot.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Speckled subnuclear compartment.
Protein: GIPC2_RAT
Sequence: MPLGLRGKKKAAKSKETARLVEGERSGGSQGVPGPPAPARRLVFHAQLAHGSATGRVEDFSSISELYAKIAGVFEIAPSEILFCTLNTPKIDMGKLLGGQLGLEDFIFAHVKGIKKEVNVYKSEDSLGLTITDNGVGYAFIKRIKDGSTIDSVKTICVGDHIECINGENIVGWRHFEVAKKLKELKKEELFTLQLIEPKKAFEIGPRSKAGKTSTEKIGTSRGTLRLRSKGPATVEDLPSEAKAKAIEKVDDLLELYMGIRDIDLATTMFEAGKDKSNPDEFAVALDETLGDFAFPDEFMFDVWGAISDVKQGR
What are the official names of this protein?
PDZ domain-containing protein GIPC2.
What is the protein family that this protein belongs to?
Belongs to the GIPC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YANB_ASPNA
Sequence: MDRIDVHHHFIPPAYVEAFKTTGGDPSGWHLPQWTPESSLSLMDSHNTRTAILSLTAPGTSILAHSPGASATLAREINLYAAKLHNENPTRFGFFASLPHLTPDTIPAAIEEAIYALETLHADGITLYTRYTGTGYLGHDAFAPLWEELNRRKAVVFIHPTNTAADARNRSILVNPALPQPIIDYPHETCRTAVDLITSGTISRNPDVKIILSHGGGTLPILATRAAHLLYDAKLTSISPEDFLEQARSFYFDLALSGNDENMQLLVGRNGFAKGGHVFYGSDFPYAPVSTINKYVRMMEGFSVQGEEVEKAIARDSAVKLFPRFQMPADLRVGKTNNWGAFSACLLLPVGLSALYSVLQSRVHTYST
What is the function of this protein?
Decarboxylase; part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria (PubMed:24684908).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA (PubMed:24684908).  6-MSA is then converted to m-cresol by the decarboxylase yanB (PubMed:24684908).  The cytochrome P450 monooxygenase yanC then catalyzes the oxidation of m-cresol to toluquinol (PubMed:24684908).  Epoxidation of toluquinol is then performed by the short chain dehydrogenase yanD, with the help of yanE, and a further prenylation by yanG leads to 7-deacetoxyyanuthone A (PubMed:24684908).  The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase yanH to yield 22-deacetylyanuthone A (PubMed:24684908).  O-Mevalon transferase yanI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (PubMed:24684908).  Finally, the FAD-dependent monooxygenase yanF oxidizes the hydroxyl group at C15 of yanuthone E to form yanuthone D (PubMed:24684908).  Furthermore, several branching points in the pathway lead to the production of yanuthones F and G from 7-deacetoxyyanuthone A; yanuthones H and I from 22-deacetylyanuthone A; and yanuthone J from yanuthone E (PubMed:24684908).
What are the official names of this protein?
Decarboxylase yanB, Yanuthone D biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.