PharMolix/UniProtQA huggingface dataset:
Protein: TBA1_HORVU
Sequence: MREIISIHIGQAGIQVGNACWELYCLEHGINQDGTMPSDTTVGVAHDAFNTFFSETGAGKHVPRAIFVDLEPTVIDEVRTGAYRQLFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLDRVRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVPEITNAVFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTVQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGADDEGDEGDDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VAGO_DROME
Sequence: MESISSMIYLVAMMSLIIGGSQAIPYRPSAYLYNQQYCMDTLTGRQLYIGEVFTREDQCVRIQCLETLQLWEDSCQVPKLTQGNCTPVPSTNPHAEYPRCCPLYECKSYESNSGGTLEQTNIYDHYGTLRSSHLTEMIVIDGRTPPRGEIHTASARKYQV
What is the function of this protein?
Probably involved in the antiviral immune response (PubMed:18953338).  May have a role in controlling viral load in the adult fat body, after infection with viruses such as the Drosophila C virus (PubMed:18953338).
What are the official names of this protein?
Protein Vago.
Protein: KCY_COREF
Sequence: MPDGGLIIAIDGPSGTGKSTTSRALATRLNAKYLDTGAMYRVATLHVLNQGIDPADTDAVITATAALPLAISDDPSSTEVLLAGVDVQTEIRGPEVTSHVSAVSAIPEVRDNLVNLQRALADRAHRCVVEGRDIGTVVLVDAPVKAYLTASPEVRAQRRYDQDTAAGRAADFDEVLAAVVKRDELDSTRAASPLKPAEDAHIIDTSAMTMDEVLTHLIQLTEASAERSNQ
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_VERA1
Sequence: MAASFKALPQQLTLTRSFARCYSVSAESIPAAKKKYVPTEGSYPQGFQASGILVGVKPGNKTKPDLAFLTSDRPCAAAAVFTKNKFQAAPVTFSRDLLKRRGNRGIRGVLINSGCANAVTGKGGLEDASLMAKAADEQLGGEDGAGSSTIVMSTGVIGQRLPIDKIVGNVGAAHGALGSGHKDWLACATAICTTDTFPKLMSRTFSLPSSPGVEYRMAGMTKGAGMIHPNMATLLGVVATDAPIAPGVMPSVLKHAVDRSFNSITIDGDTSTNDTVALLANGAAGGQEISSVDSPDYAAFQTVLSDFSADLAKLIVRDGEGATKFVTIRVVDSASEEAARKVASTIARSPLVKTALYGRDANWGRILCATGYALISEPGQDINEVASIVSEKTNVSFVPTDGSAELKLLVNGEPETVDEARASEILELEDLEILVKLGTGDKQATYWTCDYSHEYITINGDYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: BGAT2_RAT
Sequence: MKDLRFGRLKCYSLHLGILPLTVLVLVFFCFVCLSLRSQEWGHPGAVNRKAYPQPRVLTPTRTDVLVLTPWLAPIIWEGTFDIDTLNEQFRLRNTTIGLTVFAVKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVPLGAGRRLVVLTVRNYTRWQDVSMHRMEVISHFSEQRFRHEVDYLVCADVDMKFRDHVGVEILSALFGTLHPGFYRSRRESFTYERRPQSQAYIPWDQGDFYYMGAFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYMWDQQLLGWPSIMKKLRYVAVPKNHQAIRN
What is the function of this protein?
Posseses strong B transferase activity and a weak A transferase activity.
What are the official names of this protein?
Histo-blood group ABO system transferase 2, B blood group galactosyltransferase, Blood group A glycosyltransferase 2, Cis-AB transferase 2, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT 2, Putative blood group A transferase T2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity).
Protein: GSPL_XANCP
Sequence: MTAWRDTLGRIGVRAMPGAGGFWRWWQQSLLAWLPQRWQWQLGLSQSRLLLQLDGEALQLLRQRDQTSDTVASLPWPVQPQEVNALLPTALEGLPQHWLLPASHALRRPLRLPAAAAARLQDVARFEIDRQTPFTADQVYFDARVLDVREDGQLDAELVVVPRRMIDGPAGVPEAWSNALSGIDVADARGAPLGVNLLPPARRLRRSDPMQRWNLLLAVAALVLLAVAGWLLLDNRRQAADDLRAQVQANAGRARQVAAERQQLLELVEGAAFFQEQRATRPTSVEIWDELSRRLPSGTYLEKFSVEGGQLQLIGLSKEASSLVRRLEGSPLWHTPSLTGVLQSDAGRNVDRFTITAELAGPDAKEAADAAQR
What is the function of this protein?
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in the complex assembly and recruits XpsM resulting in a stable complex in the inner membrane.  Provides thus a link between the energy-providing XpsE protein in the cytoplasm and the rest of the T2SS machinery.
What are the official names of this protein?
Type II secretion system protein L, T2SS protein L, General secretion pathway protein L.
What is the protein family that this protein belongs to?
Belongs to the GSP L family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DNAG_STAEQ
Sequence: MRIDQSVIDEIKNKTDILDLVSEYVKLEKRGRNYIGLCPFHDEKTPSFTVSEDKQICHCFGCKKGGNVFQFTQEIKDVSFVEAVKDLGERVNIQVDIGQNQTNSSTKIASDELKMIEMHELIKDYYHYALMKTVEGEEALNYLHERGFTDDLIKEREIGYAPDNSHFCHDFLEKKGYDIELAFEAGLLSRNEENFTYFDRFRNRIMFPLKNGQGRIVGYSGRTYTDQEPKYLNSPETPIFQKRRILYNLNKARKFIRKQDEIILLEGFMDVIKSDYAGLKQVVASMGTQLSQEHITFLQKLTQNVTLMFDGDYAGKEATLKTGQALLNQGLNVYVVQLPSGMDPDDYIRKYDNEQFLKFVQQDKQSFVLFKVKMYQNEINHNDLAYEKHFKETVRDLSLVNSGIIRNKLIQNIADIFKVNPETIQYELDATYQHQMSSNTYPTFQDEPSKQQLILGRLTKNEKAERALIKHLTKDKDTFLNYYQKIVPEDFTNSYLKRIFSYLYDYYSKNDYYTISDMMQYIESNELREVLIELDQYHLNDEPYENEIEDYIQIIKNNNNEDSLESLNYKLREASRIGDSELQKYYLQLIVNKNKNRM
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: RL19_MESH7
Sequence: MQAKLIEILESSQIRLYPQFQPGDNVRVYFKIQEGNKTRIQIFEGLVIKFKKNGLSSNFVVRKISHNVGVERTFLLHSPLVDKVEVIRSNKVRRAKLYYMKKRSGKSARLKEIKRKELKNL
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: Y1374_SYNY3
Sequence: MSQSLSAEKLHFTTKLAYGAGDFGPAITANILVFYLLFFLTDVAGIPAALAGSVLMIGKIFDAINDPIIGLLSDRTRSRWGRRLPWMLGGMIPFALFYTAQWLIPHFSDDRLTNQWGLFIYYVAIAMAFNLCYTTVNLPYTALTPELTQNYNERTRLNSFRFAFSIGGSILSLILYILIAAGLPDRPQQQFGELGVMISVLSISALLWSALRLQEKGKEPILSPSLRRRLAPLLMAAGITLILLAIAKSFNLLGGSGFDYISFFLILLGLIWGGFGFTLRDSAVEEHLQKLENSPSPGVTENLPLLKQLKIAFSNRAFLFVIGIYLCSWLAVQLTASILVYFVVSWMGLNEQQSGTIALAVQGTALVMLFVWQALAQFLDKKVIYFLGSMVWMGAEAGLWLVQPGQVALLYTLAIFAGVGVSVAYLIPWSMIPDVVDLDELNTGKRREGFFYAFMVLLQKVGLALGLFLVGLTLEASGFIARIPGEPIPIQPDSALWAIRFAVAPLPAFFLLGGLILAIFYPITRAVHTDIRQQLQARQQNNHI
What are the official names of this protein?
Uncharacterized symporter sll1374.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: M2K3_ARATH
Sequence: MAALEELKKKLSPLFDAEKGFSSSSSLDPNDSYLLSDGGTVNLLSRSYGVYNFNELGLQKCTSSHVDESESSETTYQCASHEMRVFGAIGSGASSVVQRAIHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFHGAFYSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDIKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECGTGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDARPTADQLLSHPFITKHEKERVDLATFVQSIFDPTQRLKDLADMLTIHYYSLFDGFDDLWHHAKSLYTETSVFSFSGKHNTGSTEIFSALSDIRNTLTGDLPSEKLVHVVEKLHCKPCGSGGVIIRAVGSFIVGNQFLICGDGVQAEGLPSFKDLGFDVASRRVGRFQEQFVVESGDLIGKYFLAKQELYITNLD
What is the function of this protein?
MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression.  Activates by phosphorylation the downstream MPK6, MPK7 and MPK8.  MKK3-MPK7 module acts as a positive regulator of PR1 gene expression.  MKK3-MPK8 module negatively regulates ROS accumulation through controlling expression of the RBOHD gene.  Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses.  Activator of the C group MAP kinases.  Activates MPK7 in response to ABA (PubMed:25720833).  Mitogen-activated protein kinase (MAPK) that is specifically regulated by MAPKKK20 and mediates signaling that regulates cortical microtubule functions (PubMed:28848569).
What are the official names of this protein?
Mitogen-activated protein kinase kinase 3, AtMKK3, MAP kinase kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: COAD_KOSOT
Sequence: MKAIYPGSFDPITYGHMDILKRASKIFDEVVVLVMKNINKRYFFTFSERLSMVEKAVEGIQNARADSYEGLLVDYARKAGIKIVVRGLRAISDFEMEIQVAHINKAMYADLETVFLMTDPKYSFLSSSIVREAASFGGDVSLWVPPYVEEALKRKFSGST
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP1_THEVO
Sequence: MIYISEFIGRHVEVIQSSNRYDVGISGQVSFETKNTFEITKGTGKVIVPKEGRIFTFDGKFKVDGSLINYRPEDRLREYRKILKKLGGN
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 1, RNase P component 1, Rpp29.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_OCEIH
Sequence: MSECIGMLLAGGEGKRLGMLTKQGAKPAVPFGGKYRIIDFTLSNCTNSGIQTVGILTQYAPLELNKHIGNGKPWDMNHQHGGVSILPPYTGTKGGDWYSGTADAIYQNMNFIHQYEPEYVLIISGDHIYQMDYQQMLEQHKRTNADVTISVIEVPWAEAGRFGILHANDEQIIYEFEEKPKNPSSNLASMGIYIFNWKTLKKYLIEDANKPNSSRDFGKDIIPSMLNNQHRLYAFKFNGYWKDVGTIQSYWEANMDVLKDNNGYFSLHDRNWRIYTHDSNLPPHFIGTNGKAVNSYINSGSIIYGHIKNSIVFRNVSVQQGSYINQSIIHPNVKIGKDCVLDRVIVMENTTIPEGTIFRSDKEIEPFIINNEILNSMLAPAGGDV
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MOEA1_MYCTU
Sequence: MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
What is the function of this protein?
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
What are the official names of this protein?
Molybdopterin molybdenumtransferase 1, MPT Mo-transferase 1.
What is the protein family that this protein belongs to?
Belongs to the MoeA family.
Protein: SDF2A_DROME
Sequence: MLRQLRLTMDISGWIFLPWRRSMSNMKDSPPPPPPLASTFNDVIVDYEDPDYLPLPEYPVRPNEPLETRKQRLLYQSRKRGMLENDLLLSTFAAKHLQNFSAEQTAQYDQLINGVSNDWDIYYWATEVKPTPKEYDTEIMGLLKEHVKNAERVTRLRQPDLNI
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2-A, mitochondrial, SDH assembly factor 2-A, SDHAF2-A.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GALT4_DROME
Sequence: MAIKKRYVKRLLRKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTMLDTFYDGLK
What is the function of this protein?
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide.  In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties.  Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.  Prefers the diglycosylated Muc5AC-3/13 as substrate.
What are the official names of this protein?
N-acetylgalactosaminyltransferase 4, Protein-UDP acetylgalactosaminyltransferase 4, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4, pp-GaNTase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: MENB_ECOL6
Sequence: MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
What is the function of this protein?
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA synthase, DHNA-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
Protein: PGK_PINST
Sequence: FAVGTESIAKTFSEALDTTKISDVLSK
What are the official names of this protein?
Putative phosphoglycerate kinase, PS15.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
Protein: ES8L1_HUMAN
Sequence: MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI
What is the function of this protein?
Stimulates guanine exchange activity of SOS1.  May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
What are the official names of this protein?
Epidermal growth factor receptor kinase substrate 8-like protein 1, EPS8-like protein 1, Epidermal growth factor receptor pathway substrate 8-related protein 1, EPS8-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the EPS8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_VEREI
Sequence: MNQVEIYTDGACKGNPGPGGWGVLLRSGPTEKALFGGALGTTNNRMELMAVIEALSALQRPCAVTLYLDSEYVRKGITEWIHGWKAKGWRTAARQPVKNVDLWQRLDALVSTGGHRIEWRWVKGHSGDPGNERADALANRGVDQALGRGALASAE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF2M_YEAST
Sequence: MWKWNVRRWAGARVNISKNRLSVINVGSRYLSTARSPLSKVRNIGIIAHIDAGKTTTTERMLYYAGISKHIGDVDTGDTITDFLEQERSRGITIQSAAISFPWRNTFAINLIDTPGHIDFTFEVIRALKVIDSCVVILDAVAGVEAQTEKVWKQSKSKPKICFINKMDRMGASFNHTVNDLINKFMRGTTTKPVLVNIPYYRKQPTSNDYVFQGVIDVVNGKRLTWNPENPDEIIVDELDGTSLEQCNRCRESMIETLTEYDEDLVQHFLEEAEGDYSKVSAQFLNASIRKLTMKNMIVPVLCGASFKNIGVQPLLDAIVNYLPSPIEAELPELNDKTVPMKYDPKVGCLVNNNKNLCIALAFKVITDPIRGKQIFIRIYSGTLNSGNTVYNSTTGEKFKLGKLLIPHAGTSQPVNILTAGQIGLLTGSTVENNISTGDTLITHSSKKDGLKSLDKKKELTLKINSIFIPPPVFGVSIEPRTLSNKKSMEEALNTLITEDPSLSISQNDETGQTVLNGMGELHLEIAKDRLVNDLKADVEFGQLMVSYKETINSETNIETYESDDGYRFSLSLLPNSDALPNCLAYPLGVNENFLIMEKNGNWDKEWKYQVSFESILNSIIASCIVGLQRGGKIANFPLYACSIKINSDWSVPPDIETPQEILKITRNLIFKALNDLKPEKYNLLEPIMNLDLTIPQSDVGTVLQDLTGARKAQILSIEDESSVSNSGASTCNSPENSNRIYIPSDAVTTLHATKDKKNTQETSSNVKKIIKAKVPLREITTYTNKLRSLSQGRGEFNIEYSDMEKVTNDRLQSILHDL
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation (By similarity).  Required for respiratory growth and essential for mitochondrial genome maintenance.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MANBA_ASPAC
Sequence: MRALPTTATTLLGVLFFPSASRSQYVRDLGTEQWTLSSATLNRTVPAQFPSQVHMDLLREGIIDEPYNDLNDFNLRWIADANWTYTSGKIEGLGEDYESTWLVFDGLDTFASISFCGQFVGATDNQFRQYMFDVSSILKACPEEPTLGIQFGSAPNIVDAIAQDPSSPTWPEGVQITYEYPNRWFMRKEQSDFGWDWGPAFAPAGPWKPGYVVQLKQAAPVYVRNTDLDIYRLGQINYLPPDQTQPWVVNASLDYLGSLPENPSMAIEVKDLQSGEILASRPLTNITVTEGSVTGVTVLEGVDPKLWWPQGLGDQNLYNVTISVTDGGNQSVAEVTKRTGFRTIFLNQRNITDAQLAQGIAPGANWHFEVNGHEFYAKGSNLIPPDCFWTRVTEDTMTRLFDAVVAGNQNMLRVWSSGAYLHDYIYDLADEKGILLCSEFQFSDALYPTDDAFLENVAAEVVYNVRRVNHHPSLALWAGGNEIESLMLLLVEAADPESYPFYVGEYEKMYISLFLPLVYENTRSISYSPSSTTEGYLDIDLSAPVPMAERYSNTTEGEYYGDTDHYNYDASIAFDYGTYPVGRFANEFGFHSMPSLQTWQQALTDPADLTFNSSVVMLRNHHYPAGGLMTDNYHNTVARHGRNDPGRAGLLPDAQHSVRPRGQLQRLVPRDPALPGGPLQVTNPVLPAGQRAARTPARVPVLAARGHLAGALVGGDRVRRPLEGPHYVARDIYKPVIVSPFWNYTTGALDIYVTSDLWTAAAGSVTLTWRDLSGKPIASNGGLPTKPLPFHVGALNSTRLYRMNMKQQPLPRHEDAILALELTATGSLPNTDEEVTFTHEQWFTPAFPKDLDLVNLRVRVEYDAPLGKFAVEATAGVALYTWLEHPEGVVGYFEENSFVVVPGQKKVVGFVVQADETDGEWVHDVTVRSLWDLNEGE
What is the function of this protein?
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length.  Involved in the degradation of polymeric mannan and galactomannan.  Releases the terminal mannose residue from mannotriose and is somewaht less active on other mannooligosaccharides.
What are the official names of this protein?
Beta-mannosidase A, Mannanase A, Mannase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SPI1_RAT
Sequence: MLQACKMEGFPLVAPPSDELVTYESELYQRQTHDYYSLIGGDGDSHSDHYWDFSTHHVHSEFESFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMAPPHASLSHQVSYMPRVCFPYPPLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
What is the function of this protein?
Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites.  Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity).  Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R or FCER1A (PubMed:15304324).  Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors.  FCER1A transactivation is achieved in cooperation with GATA1 (PubMed:15304324).  May be particularly important for the pro- to pre-B cell transition.  Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity).  In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
What are the official names of this protein?
Transcription factor PU.1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RM16_YEAST
Sequence: MFPYLTRMNLSIKMGGLTLKESSPNAFLNNTTIARRFKHEYAPRFKIVQKKQKGRVPVRTGGSIKGSTLQFGKYGLRLKSEGIRISAQQLKEADNAIMRYVRPLNNGHLWRRLCTNVAVCIKGNETRMGKGKGGFDHWMVRVPTGKILFEINGDDLHEKVAREAFRKAGTKLPGVYEFVSLDSLVRVGLHSFKNPKDDPVKNFYDENAKKPSKKYLNILKSQEPQYKLFRGR
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein L16, mitochondrial, Mitochondrial large ribosomal subunit protein uL16m, YmL47.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.