PharMolix/UniProtQA huggingface dataset:
Protein: EFP_PELPB
Sequence: MISISNVSKGAIIRFKGEPHSIESLMHRTPGNLRAFYQANMRNLKSGRNVEYRFSATESVDVIITERKQYQYLYRDGSDFVMMDSETFDQINVPEIAIGSASRFVKDGITVTIVFSDDASILGVELPTFVEVEVTETSPASKDDRATSGTKPAMVETGTEVSVPMFIQTGSIIRVDTRTGEYIERVKK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHZA_PSEFL
Sequence: MPGSLSSGGFNDHLELRRKNRATVDQYMRTNGEDRLRRHELFTPDGSGGSWNTETGEPLVFKGHAKLAALGVWLHQCFPDWQWHNVRVFETDNPNHFWVESDGRGTTRVPGYPEGYCENHYIHSFELDNGKITQNREFMNPFEQLRALGIPVPKIKREGIPAS
What is the function of this protein?
Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control.
What are the official names of this protein?
Phenazine biosynthesis protein PhzA.
What is the protein family that this protein belongs to?
Belongs to the PhzA/PhzB family.
Protein: COMA_NEIGO
Sequence: MLCVLAGAAYGVFRTEAALSSQWRAEAVSGVPLTVEVTDMPRSDGRRVQFAAKAVDSGGRTFDLLLSDYKRREWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGVGGVGTVGADRVLLHGGSGWGIAVWRSRISRNWRQADADGGLSDGIGLMRALSVGEQSALRPGLWQAFRPLGLTHLVSISGLHVTMVAVLFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAFAWAWRRGRLSAWATWWQALAAVLLFDPLAVLGVGTWLSFGLVAALIWACAGRLYEGKRQTAVRGQWAASVLSLVLLGYLFASLPLVSPLVNAVSIPWFSWVLTPLALLGSVVPFAPLQQAGAFLAEYTLRFLVWLADVSPEFAVAAAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAGFVSYRPEAVPENEAAVTVWDAGQGLSVLVRTANRHLLFDTGTVAAAQTGIVPSLNAAGVRRLDKLVLSHHDSDHDGGFQAVGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLRPSERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVGKYGGNLYSQVLVLGHHGSNTSSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGGVKAQRLRVYKFYWQKKPFE
What is the function of this protein?
Essential for natural transformation.  Could be a transporter involved in DNA uptake.
What are the official names of this protein?
Competence protein ComA.
What is the protein family that this protein belongs to?
To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHLN_ANGEV
Sequence: MNTFEILTFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNALGVMIFAEPRYAMAELEEGDISAQLNDHEELKRLCLHIKKDRNPSVIVWIGTCTTEIIKMDLEGIAPKVETEIGIPIVVARANGLDYAFTQGEDTVLAAITHRCPEYKSWVDEEDGTEKKVLSVYSERNRDETFKSPNHPPLVLFGSVPSTVASQLDSELKRQSIRVSGWLPAQRYTELPSLGEEVYVCGVNPFLSRTATTLMRRRKCKLIGAPFPIGPDGTRAWIEKICSVFGIKPQGLEERETQIWNNLKDYLDLLRGKSVFFMGDNLLEVSLARFLIRCGMIVYEIGIPYMDKRYQAAELSLLQDTCKKMHIPMPRIVEKPDNYNQIQRMRELQPDLAITGMAHANPLEARGINTKWSVEFTFAQIHGFTNAKDVLELVTRPLRRNNSLEHLGWTNLLQPTII
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS20_SYNPW
Sequence: MANNKSSKKRVEIAERNRLQNKAYKSSMRTLMKRCFSACEAYNATPGDEAKTSVQASMNAAFSKIDKAVKRGVLHRNAGAHQKARLSVAVKKAIDPAPASAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: LYSC_PAROL
Sequence: MRTLVVLLLVAVANARVYERCEWARLLRNQGMDGYRGISLANWVCLTEWESHYNTRATNHNTDGSTDYGIFQINSRWWCNDSQTPTSNACNIRCSELLTDDVIVAIKCAKRVVRDPNGIGAWVAWRQHCQGQDLSSYLAGCGL
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRSJ_ECOLX
Sequence: MVVNKTTAVLYLIALSLSGFIHTFLRAEERGIYDDVFTADELHHYRINERGGRTGSLAVSGALLSSPCTLVSNEVPLSLRPENHSASRGAPLMLRLAGCGDGGALQPGKRGVAMTVSGSLVTGPGSGSALLPDRKLSGCDHLVIHDGDTFLLCRPDRRQEEMLAAWRKRATQEGEYSDARSNPAMLRLSIKYE
What is the function of this protein?
This protein maintains pilus integrity and thus is an important participant in pilus assembly.  It may function as molecular chaperone directly or indirectly in the correct assembly of PapA subunits.
What are the official names of this protein?
Protein PrsJ.
What are the subcellular locations of this protein?
Periplasm.
Protein: ECM14_ASPNC
Sequence: MRHLLSLLVLLIASAALVSAVPAGSIITPQPPVEPVHLLSSQPSDPRRPWIRLRDWIIESIWGIEKPASRRFPLNDSPRNRSPPSRILARYGSDVVLRFSLRNHDEAEALAQAADILFLDVWASTPAFVDIRLAEEVIPSLLGLLPNSLQTAYTPLIDNLAERIYTTYPSKKPIGLEGQSGFASSSRPAPKFGDLFFHEYQPLSVIIPWMRLLASMFPSHVRMISVGVSYEGREIPALRLSAGSSTAASGPRKTIIVTGGSHAREWIGTSTVNHVMYTLITKYGKSKAVTRLLQDFDWIMIPTINPDGYVYTWETDRLWRKNRQRTSLRFCPGIDLDRAWGFEWDGGRTRANPCSENYAGDEPFEGMEAQQLAQWALNETQNNNADIVSFLDLHSYSQTILYPFSYSCSSIPPTLESLEELGLGLAKAIRYATHEIYDVTSACEGIVTASAADNNPGRFFPIGGNSGGSALDWFYHQVHATYSYQIKLRDRGSYGFLLPSEHIIPTGKEIYNVVLKLGSFLIGGDSFDVDWESELFDLSKDESDLDSRYSKSNDRSPAYLHNANGPLPNIDEDEDKEWVMVEEEDYTDDDDDDDDDDEEEEEEEEDTYWATEHTYEFRRRR
What is the function of this protein?
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
What are the official names of this protein?
Inactive metallocarboxypeptidase ecm14.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Vacuole. Secreted.
Protein: YCF12_ADICA
Sequence: MNLEIITQLVVLTLVAASGPLVIALLAIRKGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PQQC_KLEP7
Sequence: MLITDTLSPQAFEEALRAKGDFYHIHHPYHIAMHNGNATREQIQGWVANRFYYQTTIPLKDAAIMANCPDAQTRRKWVQRILDHDGSHGEDGGIEAWLRLGEAVGLSRDDLLSERHVLPGVRFAVDAYLNFARRACWQEAACSSLTELFAPQIHQSRLDSWPQHYPWIKEEGYFYFRSRLSQANRDVEHGLALAKAYCDSAEKQNRMLEILQFKLDILWSMLDAMTMAYALQRPPYHTVTDKAAWHTTRLV
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: IF1_VIBC3
Sequence: MAKEDVIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVEMTPYDLSKGRIVFRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_MYCBP
Sequence: MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYEQARNSRALASR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLB_COXBR
Sequence: MSLISNNEERSLRVRYCIAIALSALLISGCTTLRLPNQSTSVYHQQTWAQRYYDLSRISQWNIDGAFSIQQPGKTIIAAYDWQQKGMNYRIRIHSSLDIYSVNISGRPGMVTLWRSPRQHYTASTPEQLMQQQLGWQLPLSNLYYWIRGIPAPGAYQADFDTYTHLIALQQSGWHIRFSQYTTVGSVDLPRTLQLSNGPLAVKIVVKHWQ
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RECX_BACCN
Sequence: MAVITKIEVQKRTKERFNIYIDKGQGEEYGFSVNQAVLIKHGLQKGLEIDEVEIANILYNEEVQKAYLQAISYLSYQMRTKQEVEEYLRKKEVGQAIISEVISKLLHDRYINDKEYAVLYVRTQSNVNQKGPSVIRKELLRKGVQEVIITHSLQEYPKEKQVDNAFMLIEKKKRSYQKHSFLQMKQKLEDMLIRKGFSRDVIQICLEELKEEKDDSKQQEALYYHGNKYYEKYKKYDGWTFENKMKQALYRKGFSIDEIEGFLQMKCEEG
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAD1_YEAST
Sequence: MEVDNKRRHSEDELKQEAVKKIKSQEPNYAYLETVVREKLDFDSEKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFIHSIDENHHVFLNLTSLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPKDLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRDHFLLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLNPIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKVENKPEASESVTGKVIVKPFWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKSRSSSTSTVFELTRLPQFLIFHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIKQPSTDGNAFNGDEKSHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE
What is the function of this protein?
Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle.  Required for splicing of pre-mRNA.
What are the official names of this protein?
Pre-mRNA-splicing factor SAD1, snRNP assembly-defective protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPH_EHRRW
Sequence: MHNAIYTDLQKEVEVILARPRGFCAGVSRAIEIVKLAIEYYKDTKTIYVLHEIVHNKYIVETLKTMGVIFIDKVDQAQDGSVLIYSAHGVSKSIKQLAELRDLEVIDATCPLVNKVHKEVQLYDKSGYQVILIGHKGHREVEGTVGQISTPVIIVQNLNDIDKIEIFDPDKLAYVTQTTLSVDDTKVIIDKLKKKFPNIKGPDLKDICYATQNRQTTTKRLAELVDIVFILGSKNSSNSNRLKELAGIQTQAFLIDSYKEIDLNLLNDITKIGITAGASAPDILVQQVIDFLKQHMKVKLSDLEIVQESVTFNVPRQLRQYKEQYNPI
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: LECM_NOTSC
Sequence: MGRFLLVTLSMLVVTFSLNEANSCCCPQDWLPKNGFCYKVFNDLKNWNDAEMFCRKFKPGCHLASIHSNADSADLAEYISDYLKSDGHVWIGLNDPRKQRTWVWSDRSSTNYLAWNQGEPNNSKNIEYCVHLWALTGYLKWNDTPCEALYHFICQCKF
What is the function of this protein?
Mannose-binding lectin that binds to and agglutinates erythrocytes in a calcium-dependent manner.
What are the official names of this protein?
C-type lectin mannose-binding isoform, CTL, Venom C-type lectin mannose binding isoform 1.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ALB1F_PEA
Sequence: MASVKLASLIVLFATLGMFLTKNVGAASCNGVCSPFEMPPCGTSACRCIPVGLVIGYCRNPSGVFLRTNDEHPNLCESDADCRKKGSGKFCGHYPNPGIEYGWCFASKSEAEDFFSKITQKDLLKSVSTA
What is the function of this protein?
PA1b binds to basic 7S globulin (BG) and stimulates its phosphorylation activity.  Involved in the signal transduction system to regulate the growth and differentiation as a hormone peptide (By similarity).  Toxic to various insects through binding to a high affinity binding site in the insect gut.
What are the official names of this protein?
Albumin-1 F, PA1 F, PsaA1b005/PsaA1b011.
Protein: PYRE_SPHAL
Sequence: MTDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPRELKQAIDLVVSPAMGGVIIGHEMGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVVTTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVPFYPLVAINFPTYAADELPPELAGTEAIKPGSRSVAA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PEN2_MOUSE
Sequence: MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:24941111).  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).  PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:24941111).
What are the official names of this protein?
Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2.
What is the protein family that this protein belongs to?
Belongs to the PEN-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein: RAB1A_CANLF
Sequence: MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:1429835).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:1429835).  RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:1429835).  Required to modulate the compacted morphology of the Golgi.  Regulates the level of CASR present at the cell membrane.  Plays a role in cell adhesion and cell migration, via its role in protein trafficking.  Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity).  Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
What are the official names of this protein?
Ras-related protein Rab-1A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms.
Protein: KIBRA_MOUSE
Sequence: MPRPELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQGGYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLEFEDTELSTTLCELNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASAQRPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQLSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLDSANTLVFNEAFWVSISYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQCREPQPTEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEEEGEEDVFTEKVSPEAEECPALKVDRETNTDSVAPSPTVVRPKDRRVGAPSTGPFLRGNTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRTERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLEKKVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
What is the function of this protein?
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis.  Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation.  Regulates collagen-stimulated activation of the ERK/MAPK cascade.  Modulates directional migration of podocytes.  Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity).  Regulates collagen-stimulated activation of the ERK/MAPK cascade.
What are the official names of this protein?
Protein KIBRA, Kidney and brain protein, KIBRA, WW domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the WWC family. KIBRA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
Protein: ATPE_STAHJ
Sequence: MSTVNLDIVTPNGSVYEKDDVELVVFQTTAGEMGVMSGHIPTVAALKTGHVKVNFRNGTEYIAVSGGFVEIRQHKVSVIVQTAETASEIDVERAKLARQRAQSHLEDQDNSDINRAKRALARAENRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RLMH_SHEB5
Sequence: MKLQLIAVGTRMPDWVTRGFEEYQRRFPRDMALELIEIPAGKRGKNADIVRILQKEGEQMLAAIPKGNHIVSLDLPGKNWTTPELATALTKWQLDGRDVSLLIGGPEGLAPACKEAANQSWCLSALTLPHPLVRVVVAESLYRAWSVNTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_SHEB2
Sequence: MRIGILGGTFDPIHYGHIRPAIEVKHALALDKILLMPNHIPPHKQQPNLTTAQRLNMVADVCSQLDGFELCDIEAKRDTPSYTVVTLEQLKALHPEDELFFIMGMDSFLQLKSWYEWQRLFNFAHLVVCQRPGWQLDAAHPMQQILTARSHAHQETHEGHAKNTHKNSGQIFPVTITPQDISSTQIREQLAKGEIPADLLMPITLDYIQNQRLYLP
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: ATNM_ARTSZ
Sequence: MLDIPLSESLQHPGTRVAVNIIISIAAIALVRVIGSRWLTQYHLRALPLVNGLGLFESGKRAKGSFLFNAQGLLDEGYAKSSKAFRVQTDSEQVVVLAPECASEIRNDDRFSFTNLLAEDFLAHIPAFVNFSPHNGLNDMANDVITKKLNPALGLVTPDLSAEATLTFRDHWTDSTEWHSVNVKGTILEIVARLSSRVFLGPELCRNPAWLRITVDYTTNLFFGVVALKKWRSFLHPLVWRFVPEVRKVRQQIEEAIQLIQPVVDKRHAESRSSAASSGKKDQTLYDLCSYPEYIEPLRDELVTVLKESGMTKAGLFKLKLMDSFMKESQRFKPGAMIMMRRKVMEDVTLSNGVFLPRGVQVGIPLRSHFNPKAYSDPDKFDGYRYVKMADDPEKEVFRHFVTTSQEHMGFGFGKHSCPGRFFAANEVKVALCHILLKYDFKLAEGPKPNVMKMGWVLISDPMTNLMIKRREGIDESILE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids (PubMed:29797385).  The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids (PubMed:29797385).  The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (PubMed:29797385).  The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA (PubMed:29797385).  The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (PubMed:29797385).  The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable).  The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster (PubMed:29797385).  The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable).  For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase atnM, Arthripenoid biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.