PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_ERWT9
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEEIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGANPNVSDADSDQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRRELFLNAGRRIVALTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFDISDIDRLSRLVPHLCKVAPSTPKYHMEDVHRAGGVLGILGELDRAGLMDNSVRNILGLSLRETLDRYDIMLTQDDAVKKMFRAGPAGIRTTQAFSQDTRWETLDDDRQHGCIRAREFAFSQDGGLAVLYGNLAENGCIVKTAGVDEGSLVFSGPAKVYESQDDAVAAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHASPEAASGGTIALVKDGDIINIDIPQRGIQLDVAENELAARRLEEDARGEAAYTPHGRERQVSFALRAYATLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RPOA_ALIFM
Sequence: MQGSVTEFLKPRLVDIEQVSTTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIEGVLHEYSTKEGVQEDILEILLNLKGLAVKVEGKDEVIITLNKSGAGPVVAGDITHDGDVEIANPEHVICHLTDDNAEISMRIKVERGRGYVPSTARIHTEEDERPIGRLLVDATYSPVDKISYAVEAARVEQRTDLDKLVIDMETNGTLDPEEAIRRAATILAEQLDAFVDLRDVRVPEEKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIAED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: GLYC_BRSVL
Sequence: MSNHTHHLKLKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAKPTSKPTIQQTQRPQNHTSPLFTEHNYKSTHTSIQSTTLSQLLNIDTTRGTTYSHPTDETQNRKIKSQSTLPATRQPPINPSGSNPPENHQDHNNSQTLPYVPCSTCEGNLACSSLCQIGLERAPSRAPTITLKKAPKPKTTKKPTKTTIHHRTSPEAKLQPKNNTAAPQQGILSSPEHHTNQSTTQI
What is the function of this protein?
Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
What are the official names of this protein?
Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG.
What is the protein family that this protein belongs to?
Belongs to the pneumoviruses glycoprotein G family.
What are the subcellular locations of this protein?
[Isoform Membrane-bound glycoprotein G]: Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Isoform Secreted glycoprotein G]: Secreted. Note=The protein is shed from infected cells before the appearance of progeny virus. The initiation at the downstream methionine removes a portion of the transmembrane domain. The remaining hydrophobic portion of the sG protein is essential for translocating it into the lumen of the ER during translation and would likely maintain its membrane association until a proteolytic event releases the mature sG protein into the medium.
Protein: SFRP5_BOVIN
Sequence: MRAAAGGARAAVLALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types.  SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina.  Inhibits Wnt8 signaling, in vitro.
What are the official names of this protein?
Secreted frizzled-related protein 5, sFRP-5.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSMB_HUMAN
Sequence: MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII
What are the official names of this protein?
Beta-microseminoprotein, Immunoglobulin-binding factor, IGBF, PN44, Prostate secreted seminal plasma protein, Prostate secretory protein of 94 amino acids, PSP-94, PSP94, Seminal plasma beta-inhibin.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted. Note=Sperm surface.
Protein: TSI5_PSEAE
Sequence: MPTEGRRRGVSAAMIKHYLLMTLVCIPLALLYVCLEWFFGNTWVTVGVFFGVLVVLRLGLYLYRRSKGIRDGYLDE
What is the function of this protein?
Immunity protein that plays a role in preventing early activation of toxin Tse5.
What are the official names of this protein?
Immune protein Tsi5.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRMB_XANCP
Sequence: MTDPFTSDGAKMPPKPFTIEEGRRQVRSFVLRQGRFTPAQQRAFDELWPRFGLDYTGAPRDLDAVFGRPAPKVLEIGFGNGAALRFAAQHDPARDYIGIEVHAPGVGRLLNALDDDGATHVRLYHHDAVEVLEREIADGALDEVRIYFPDPWHKKRHNKRRLVQPAFAQLLVRKLRDGGRLHAATDWADYAEQMWDVLDATEGLVNRAGPRGHVARPAWRPQTHFETRGQKLGHGVWDLLYDRESGMENRESPGQAPAAPG
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PRP19_YEAST
Sequence: MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP
What is the function of this protein?
Probable ubiquitin-protein ligase involved in pre-mRNA splicing.  Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation.  It is also probably involved in DNA repair.
What are the official names of this protein?
Pre-mRNA-processing factor 19, RING-type E3 ubiquitin transferase PRP19.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PRP19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IXTPA_EXIS2
Sequence: MKIIVATRNAGKVGEFQAMLGRLGYDVESLLDYDTAPETEETGSTFEENAELKSKEAAAYFGHAVLSDDSGLEVDALDGAPGVYSARFAGEDKSDAANNALLLEKLADTPADRRTARFVCALSLAKPSGETLTVRGTMEGQIGFEQKGTNGFGYDPLFLIPSLNQTAAELTKSEKAAISHRGQALKKLEAALTTFLGE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: TAL_MYCBT
Sequence: MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARLAYAAYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTDVFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VA54_VACCC
Sequence: MTRWWRSRYICRSQCSNVKNSTCSQQILYIHLLILSYTTITKSFFKTLNHHQKSMFKVIRLKYIFEINSCISHPSILDLYVLKNTILLIL
What are the official names of this protein?
Protein A54.
Protein: TBPL2_MOUSE
Sequence: MVGSLIMEEDIYLDLFLDPYTIQDDFPPAMSQLFSPGVPLDMHSLPSNPETVFHPHLGGVKKASTDFSSVDLSFLPDELTQENRDQTVTGNKLASEESCRTRDRQSQLQLPDEHGSELNLNSNSSPDPQSCLCFDDAHSNQPSPETPNSNALPVALIASMMPMNPVPGFSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV
What is the function of this protein?
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes.  The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
What are the official names of this protein?
TATA box-binding protein-like 2, TBP-like 2, TATA box-binding protein-related factor 3, TBP-related factor 3.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokinesis.
Protein: BIOD_RHOPA
Sequence: MSARIVVTGTDTGIGKTVFAAALAGALDATYWKPVQSGLEDETDSGAVQRLSGLAADRILPERYRLQTPASPHLAAEIDGVDIDVAALELPSVSRPLVVEGAGGLMVPLTRETTYIDVFARWAAPLVLCARTSLGTINHTLLSIEAIRARDIPLLGVAFLGDENLDSEQIIVELGHTRRLGRLPRLERLDAAALRAGFAAAFEPRDFLGDAP
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECG_ECODH
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIIMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: YBFG_ECOLI
Sequence: MREMNQLVNTEDSAWPIIQNWLKDATNHTELLPVNKDLAETALYQLQVTTKSPMGALVYGSGGLLIDNGXLRIAGSGHPRLPRDPVSWTQRPEFAGVRALPIADDVAGVIFALNGGDLGEDTGCVYYFAPDTLNWESLEVGYSEFLQWALSGDLDTFYENVRWQQWREDVIKLSATEAFTFYPFLWVQSEEARTRKVISLTELWEMQYQMKETFTQ
What are the official names of this protein?
Putative uncharacterized protein YbfG.
Protein: PLSY_LARHH
Sequence: MTTIASLVLAYLLGSVPFAVLVSLGMGLADPRSYGSGNPGATNVLRSGNKLAALLTLLGDAAKGWLAVWLAQTYGASFGLAAPEIAMVGLAVFIGHLWPVFLAFRGGKGVATALGVLLAVNPWLALIAAAVWLAVALLTRYSSLAAMVSAVATAVAAWFIEPGVYAGLTIVIALLLVRRHKQNILNLVSGTESRIGGKKKS
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPAT_PROM9
Sequence: MVQVNENYLKLKAGYLFPEIAKRVKIYSQSNKSAEIIKLGIGDVTEPLPRACIDAMSKALDDMGTAEGFRGYGPEQGYSWLREKISEHDFISRGCQILPEEIFVSDGSKCDSSNILDILGKDNSIAVTDPVYPVYVDSNVMTGRTGDALENGTYQGLTYLAINEGNNFLPELPQKKVDILYLCFPNNPTGATITKEELKKWVDYALQNKSLILFDAAYEAFIQDNDIPHSIYEIEGAKDCAIEFRSFSKNAGFTGVRCAFTVIPKNLKGLSSTNEEIDLWPLWNRRQSTKFNGVSYVVQRGAEAVYSLEGKKEVRGLIDFYMENAKIMKNKLQTAGYKVYGGDNAPYIWIKVPDQMTSWNFFDFLLQNVSVVGTPGSGFGLSGEGYFRLSAFNSRSNVLDAMERIINI
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: LIPA_SHESM
Sequence: MNRPERLQPGVKLRDADKVSRIPVKIVPSERETMLRKPDWLRVKLPASNQRILEIKQALRSNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPLKPDAEEPVKLAQTIRDMKLKYVVITSVDRDDLRDGGAQHFADCIREIRKLNPEIKIEILVPDFRGRIDAALDILSTEPPDVFNHNLETAPMHYRKARPGANYQWSLDLLKRFKERHPNVPTKSGLMMGLGETNEEIAQVLRDLREHKVEMLTLGQYLQPSKFHLPVERYVSPAEFDELKVLADELGFTHAACGPLVRSSYHADLQAQGKEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKUK_BACSU
Sequence: MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDSQVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILDGHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDSYTAFSYANRFTK
What are the official names of this protein?
Uncharacterized protein YkuK.
Protein: INT1_ARATH
Sequence: MTLTIPNAPGSSGYLDMFPERRMSYFGNSYILGLTVTAGIGGLLFGYDTGVISGALLYIKDDFEVVKQSSFLQETIVSMALVGAMIGAAAGGWINDYYGRKKATLFADVVFAAGAIVMAAAPDPYVLISGRLLVGLGVGVASVTAPVYIAEASPSEVRGGLVSTNVLMITGGQFLSYLVNSAFTQVPGTWRWMLGVSGVPAVIQFILMLFMPESPRWLFMKNRKAEAIQVLARTYDISRLEDEIDHLSAAEEEEKQRKRTVGYLDVFRSKELRLAFLAGAGLQAFQQFTGINTVMYYSPTIVQMAGFHSNQLALFLSLIVAAMNAAGTVVGIYFIDHCGRKKLALSSLFGVIISLLILSVSFFKQSETSSDGGLYGWLAVLGLALYIVFFAPGMGPVPWTVNSEIYPQQYRGICGGMSATVNWISNLIVAQTFLTIAEAAGTGMTFLILAGIAVLAVIFVIVFVPETQGLTFSEVEQIWKERAYGNISGWGSSSDSNNMEGLLEQGSQS
What is the function of this protein?
Vacuolar inositol-proton symporter involved in the release of myo-inositol from vacuoles.  Not involved in glucose or fructose transport.
What are the official names of this protein?
Inositol transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: TPM_PICAN
Sequence: FDRYNQILDEHNMNLREAEQILRYLKVKSVKDEETKKIKQEEAEMKKKIEGEASRKKLELEQRRTEQQPSGDANDMFGSTDDLMNLDLDNFRTDFLDFGETSERPQNDDMMKDIFEMKTADNSEGSAMDSLTDLNLDFLDQPAQAGPEPAAPAQEDDAGLMPTDQMENLFSQFDELVNSGDY
What are the official names of this protein?
Tropomyosin-like protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ILVC_HALOH
Sequence: MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESDGFRVFKTSEAVKRADIIQVLIPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPPDNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGKAKELGLAYAKGIGCTKAGVIETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMFEGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRPVFNALTSKDENHLIEKVGKKLRDMMPWINE
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MTLD_ACTP7
Sequence: MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVVKNIAAINSKDEEAVIEQVKSVELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIACENMVRGTSFFKAKIFENLTASQQAEIEKFVGFVDSAVDRIVPPAELNEADPLEVTVEEFSEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAIAIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIRKLSPNDRLIKPLLGTLEYGLPHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVEKYTGLTNQEVIDQVVALYN
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: THIG_CHLPD
Sequence: MDFLHLGSFVFSSRLILGTGKFSNADLMIEAIKASGAQLVTVALRRFNREQIADDLFGPLSALQGITLMPNTSGASTAREAIHAAHIARELSGSPFIKVEIHPNPQHLMPDALETWEASRILAKEGFLVMPYIPADPVLAKRLEEVGCASVMPLGSAIGSGQGLANAGMIELIIRESGIPVIVDAGLRAPSEAAAAMEMGCGAVLVNSAVAVAGNPPEMANAFAEAVRAGRRAFKAELMPKSSFALSTSPLTTFLGKKS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPA9_SHIFL
Sequence: MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALPALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
What is the function of this protein?
Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell (PubMed:18005683, PubMed:20831869, PubMed:24248594, PubMed:29024643, PubMed:29144452, PubMed:31216343, PubMed:33303953).  Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG (PubMed:18005683).  Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection (PubMed:18005683, PubMed:20010814).  Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation (PubMed:15950937).  Catalyzes 'Lys-48'-linked polyubiquitination and subsequent degradation of a subset of host guanylate-binding proteins (GBP1, GBP2, GBP4 and GBP6), thereby suppressing host cell defense (PubMed:29024643, PubMed:29144452, PubMed:31216343, PubMed:33303953).  In contrast, host GBP3 and GBP7 are not ubiquitinated by IpaH9. 8 (PubMed:29024643, PubMed:29144452, PubMed:31216343).  Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme (PubMed:18005683).
What are the official names of this protein?
E3 ubiquitin-protein ligase ipaH9.8, Invasion plasmid antigen ipaH9.8.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (PubMed:11115111, PubMed:11418613). Transported into the host nucleus (PubMed:11418613). This transport is independent of cytosolic factors, but dependent on temperature and partly on ATP/GTP (PubMed:11418613).
Protein: GSA2_STACT
Sequence: MEFTESERLQSLSDEYILGGVNSPSRSYKAVGGGAPVVMKEGKGQYLYDVDGNRYIDYLQAYGPIITGHAHPHITKAIQEQAAKGVLYGTPTELEIKFAKKLREAIPSLKKMRFVNSGTEAVMTTIRVARAYTNRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPKSVAQEVITVPFNDIEAYKEAMKHWGNEVAAVLVEPIVGNFGMVEPKPGFLEAVNEITHEYGGLVVYDEVITAFRFHYGAAQDLLNVYPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQDGVYEELDRLGKKLEDGLNELIDKHDITATINRVYGSLTLYFTDEKVTHYDQAENADGDAFAKFFKLMLNQGINLAPSKFEAWFLTTEHTDEDIEETLRAADYAFSQMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEM1_PHACH
Sequence: MAFKSLIAFVALAAAVRAAPTAVCPDGTRVSHAACCAFIPLAQDLQETIFQNECGEDAHEVIRLTFHDAIAISRSQGPKAGGGADGSMLLFPTVEPNFSANNGIDDSVNNLIPFMQKHNTISAADLVQFAGAVALSNCPGAPRLEFLAGRPNKTIAAVDGLIPEPQDSVTKILQRFEDAGGFTPFEVVSLLASHSVARADKVDQTIDAAPFDSTPFTFDTQVFLEVLLKGVGFPGSANNTGEVASPLPLGSGSDTGEMRLQSDFALAHDPRTACIWQGFVNEQAFMAASFRAAMSKLAVLGHNRNSLIDCSDVVPVPKPATGQPAMFPASTGPQDLELSCPSERFPTLTTQPGASQSLIAHCPDGSMSCPGVQFNGPA
What is the function of this protein?
Catalyzes the oxidation of Mn(2+) to Mn(3+).  The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds.
What are the official names of this protein?
Manganese peroxidase 1, MnP-1, MnP1, Manganese peroxidase isozyme 1, Peroxidase manganese-dependent 1, Peroxidase manganese-dependent I.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ligninase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FB337_ARATH
Sequence: MDTTNSSRWSELPIDILRSLLEQKGGCAIYNPDEAKDYKTKRDSSGIRFLANSVNWFLVLDSRSNLYIIDVFSEKKIDLPPLESIKNGLYSLEQVGDEKKKEYIVVWFFDKGTEYIAFCKNGEDHYRDIPIRKNVCKELQDLYDMLLHGGNNLYISKTRQSIRKLRFFEEEGFIDVDNSEILPFRKISFYIDGARFSNNIAVTTSREVLLVQNFFYETTRYRSFRLYKKDPNPDLNATINNPYPMVELCSLGDVSASGFGDRKRSCLDMCMFNLVTKKLKRFPDLSNLKLTDARCTTTSSGNNWKFSIIVSEVIDSKFLELRFADLDSESQQQTKLKFSMLKSEFVDMNKEDSQIEINEKETKINQEHDQSDETQAKRRRSLTSSVWQDLVSVGGEANVKEIDRSMETPNSSPPWSELPGDILRSVFERLSFVDFQRAKQTCPIKRSKSNCLRLWLITFGGLERLPHLSSVCFISWT
What are the official names of this protein?
Probable F-box protein At5g25300.