PharMolix/UniProtQA huggingface dataset:
Protein: AUSM_EMENI
Sequence: MSDTPTRKTDLRVIIVGGSVAGLTLAHCLANANIDHIVLEKRAEISPQEGAFLGIWPNGGRIFDQLGVYADLEKCTVPIHKMRVRFPDGVSFSSELPRQVQERFGYPIISLDRQKVLEILYNRYPAKSNIHVNKKVTEIRQTEREAQVLTADGAVYKGDLVVGADGIHSAVRAEMWRQAKDLVGRRDRQDVNHEIAAFTVEYACVFGISSPISGLESGEHVNSYSNGLCVITFHGKDGRVFWFILIKLQKRFIYPFTPRFSASDAAKICAEYANVPVWGDICVRDLWGNKTSVSMTALEEGLLETWRFKRVVLLGDSIHKMTPNIGQGANTAAEDAGVLASLLQRLSTSDSSATSCTIDAVLQEYASLRYERVKSTYQRAYFGARLHTRDDALKAFVGRYIFPRFRQQVLERTSQAIAGAPQVDFLPTPKRTGPGWSDYAGSPEVGAPTLPWLVISLPVLASMLCYLVYSSVFVTPIFP
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759).  Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759).  Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).
What are the official names of this protein?
FAD-dependent monooxygenase ausM, Austinoid biosynthesis clusters protein M.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PLA2B_ARATH
Sequence: MMFRTSLMRFAAAFFAIVFVVLVGVARSEECTRTCIAQNCDTLSIRYGKYCGIGHSGCPGEEPCDDLDACCKIHDHCVELNGMTNISCHKKFQRCVNRLSKAIKQSKNKKVGFSTKCPYSVVIPTVNQGMDIGILFSQLGNDMKTEL
What is the function of this protein?
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli.  Regulates the process of cell elongation and plays important roles in shoot gravitropism by mediating auxin-induced cell elongation.  Involved in stomatal opening in response to light.  Plays a role in pollen development and germination and tube growth.
What are the official names of this protein?
Phospholipase A2-beta, Secretory phospholipase A2-beta, AtsPLA2-beta.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum.
Protein: IL10_CANLF
Sequence: MHGSALLCCCLVLLAGVGASRHQSTLLEDDCTHFPASLPHMLRELRAAFGRVKIFFQMKDKLDNILLTGSLLEDFKSYLGCQALSEMIQFYLEEVMPRAENHDPDIKNHVNSLGEKLKTLRLRLRLRRCHRFLPCENKSKAVEQVKSAFSKLQEKGVYKAMSEFDIFINYIETYMTMRMKI
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_GLAP5
Sequence: MFTKLMTAIFGSSNDRTLRRLNKRVAQINRLEAEFEKLTDEQLQAKTAEFKQRLAEGATLDSLLHEAFATVREASKRVLGMRHFDVQLIGGMVLTERNIAEMRTGEGKTLTATLPCYLNALTGKGVHVVTVNDYLARRDAETNRPLFEFLGMTVAVNIPGLPSDVKRQAYLADITYATNSELGFDYLRDNLAHSKEERFQRPLHYALVDEVDSILIDEARTPLIISGPAEDATQIYQAIDKVIPHLIAQDKEDTEEYTGDGDFTLDLKSKQAHLTERGQVKVENILTKMGLMHEGESLYHPARISLLHHVYAALRAHKLFEVNVDYIVKDGEIVIIDEHTGRTMAGRRWSDGLHQAIEAKEGVNIQGENQTVASITYQNYFRLYEKLAGMTGTADTEAFEFQQIYGLDTVVIPTNRPMIRDDKTDLMFKSEPEKFQAVIKDIQDCIARKQPVLVGTISIEKSEALSEALKQAGIPHKVLNAKFHAQEAEIVADAGYPGAVTIATNMAGRGTDIVLGGNWKAEIAKLENPTQEQIDEIKAKWQERHDIVMQAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDALMRIYLNEGKLNMMRKAFTEEGEAMESKLLTKVIASAQAKVEAYNFDGRKQLLQYDDVANEQRKAIYEQRNYLLETDDISAMINTVREDVFNAVIDQYIPPQSIEEMWDVPALENRLKQEFGMELPIVKWLEAEDDLHEETLRERIINIAKEQYQAKEAMVGAEVMRSFEKGVMLQNLDELWKEHLSAMDYLRKGIHLRGYAQKDPKQEYKKESFAMFTDMLDHLKSNVISVLSRIQVRSQEEVEQAERERQAHAEQESSHYHAEGEGQDFSDLHIGRNEPCPCGSGKKYKHCHGSKAKYS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PP118_ARATH
Sequence: MLQPSPPHYSSSRDVRHHHHHHHHHHHLALSSKARVFPLSLPCNFSSRVSFKLQLHCAASSSSSVSPPRCSKPNPSSRKRKYGGVIPSILRSLDSSTDIETTLASLCLNLSPKEQTVLLKEQTRWERVLRVFRFFQSHQSYVPNVIHYNIVLRALGRAGKWDELRLCWIEMAHNGVLPTNNTYGMLVDVYGKAGLVKEALLWIKHMGQRMHFPDEVTMATVVRVFKNSGEFDRADRFFKGWCAGKVDLDLDSIDDFPKNGSAQSPVNLKQFLSMELFKVGARNPIEKSLHFASGSDSSPRKPRLTSTFNTLIDLYGKAGRLNDAANLFSEMLKSGVPIDTVTFNTMIHTCGTHGHLSEAESLLKKMEEKGISPDTKTYNILLSLHADAGDIEAALEYYRKIRKVGLFPDTVTHRAVLHILCQRKMVAEVEAVIAEMDRNSIRIDEHSVPVIMQMYVNEGLVVQAKALFERFQLDCVLSSTTLAAVIDVYAEKGLWVEAETVFYGKRNMSGQRNDVLEYNVMIKAYGKAKLHEKALSLFKGMKNQGTWPDECTYNSLFQMLAGVDLVDEAQRILAEMLDSGCKPGCKTYAAMIASYVRLGLLSDAVDLYEAMEKTGVKPNEVVYGSLINGFAESGMVEEAIQYFRMMEEHGVQSNHIVLTSLIKAYSKVGCLEEARRVYDKMKDSEGGPDVAASNSMLSLCADLGIVSEAESIFNALREKGTCDVISFATMMYLYKGMGMLDEAIEVAEEMRESGLLSDCTSFNQVMACYAADGQLSECCELFHEMLVERKLLLDWGTFKTLFTLLKKGGVPSEAVSQLQTAYNEAKPLATPAITATLFSAMGLYAYALESCQELTSGEIPREHFAYNAVIYTYSASGDIDMALKAYMRMQEKGLEPDIVTQAYLVGIYGKAGMVEGVKRVHSRLTFGELEPSQSLFKAVRDAYVSANRQDLADVVKKEMSIAFEAERECSSRSGEEEEDDEEENSEEDEAF
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g73710.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: SYE_YERPG
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFSRHLGGEFVLRIEDTDLGRSTQEAIDAIMDGMNWLNLDWDEGPYFQTKRFDRYNAVIDQMLDAGTAYRCYCSKERLEALREAQMANGEKPRYDGHCRDSQCTHGADEPSVVRFRNPQEGSVIFDDKIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVIDDWDMEITHVIRGEDHINNTPRQINILKALGAPVPEYAHVSMILGDDGKKLSKRHGAVGVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFSIEEMTQLFTLDAVSKSASAFNTEKLQWLNHHYINSLPPEQVAVHLSWHVEQLGIDTRNGPELVEIVKLLGERCKTLKEMAESCRYFYEEFDAFDVDAAKKHLRPIARQPLEAVKVKLAAITEWTTENVHNAIQGTADELGVGMGKVGMPLRVAVTGVGQSPGMDVTVHAIGQARTLARIDKALAFISEREAQQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_MYCBP
Sequence: MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: COAX_ACICJ
Sequence: MKLVIDAGNTNIVFAVHDGSRWRGTWRIATDAQRTSDEYGVWLTVLLDRAGIAAGGIDGAVIGTVVPAALYHLRRLCRDWFSLEPLIARAELDWGFAIEMDNPAEIGADRLLNALAAHHGYGGPLIVIDFGTATTFDVVNGNGAYVGGVIAPGINLSVEALHQAAARLPRIGIGRPQLVIGKSTIPAMRSGIYWGYVGLVEGLIARIEADFGAPMKTIATGGLAPLIAEGTSRIEHTDPDLTLEGLRLLALRNPAPVLRPREAEHE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_DESVM
Sequence: MKTYRDHYFLKAKQENYPARSIYKLKEIDNRFKLFRQGMKVLDLGAAPGSWSLGAAERVGPKGRVLACDLQTTDTQFPPNVTFMQEDVFNRSEAFEDALAAMGPFHVVISDMAPRTTGTRFTDQARSLELCIEALAVADHCLIKGGSFVVKIFMGPDVKQLLDALRARFETVKTFKPKSSRVESKETFYVCLGYRGDGQQD
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4LM_PHOVI
Sequence: MSMVYANIFLAFIMSLMGLLMYRSHLMSSLLCLEGMMLSLFVMMTVTILNNHFTLASMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NIFK_BRASP
Sequence: MAQSADHVLDHLELFRGPEYQQMLADKKMFENPRDPAEVERIRAVTKTPEYREKNFAEALAVNPAKACQPLGAVFVSVGFEGTLPFVHGSQGCVAYYRSHLSRHFKEPSSCVSSSMTEDAAVFGGLNNMIDGLANSYNMYKPKMICSTTCMAEVIGDDLNAFIKTSKEKGSVRRSSTPFAHTPAFVGSHVTGYDNALKGILEHFWNGKAGTAPKLERKPNEAINIIGGFDGNTVGNLREIKRILALMGIKHTILADNSEVFDTPTDGEFRMYDGGTHVEDTANAIHAKATISMQQWCTEKTLPFVSEHGQDVVSFNYPVGVSATDDLLVALSRISGKEIPEQLARERGRLVDAIADSSAHIHGKKFAIYGDPDLCYGLAAFLLELGAEPTHVLSTNGNNVAGENATLFAGSPFGELPAYPGRDLWHMRSLLFTEPVDFLIGNTHGKYLERDTGTPLIRIGFPIFDRHHHHRFPVWGYQGGLNVLVKILDKIFDEIDKKTSVLGKTDYSFDIIR
What is the function of this protein?
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase molybdenum-iron protein beta chain, Dinitrogenase, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: MURG_VIBCM
Sequence: MMNKNKKLMVMAGGTGGHVFPGLAVAKQLQQQGWQIRWLGTADRMEAELVPKHGIEIDFIQVKGLRGQGLMRLLKAPFQIVNAILQARRHLLTYQPDAVLGMGGYVSGPGGIAAWLLGIPVVLHEQNAVAGLTNQWLAKIARRVFQAFPGAFADASVVGNPVRQDVVQLAAPEQRFATRNGAIRILVMGGSQGARILNQTLPAVMAALGEGYEIRHQAGKNSQQDVAEAYAAAGVESAQVTEFIDDVADAYAWADLLICRSGALTVSEVSAAGVGAIFIPFMHKDRQQALNADHLVACGAAKMIEQPELSVEKLTQMVRELDRAQLLSMAQKARQAAKLDADKVVAQAIIAITE
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NM111_ASPOR
Sequence: MDLNGDAGAKRKRSSIVPAERPAKHLKPESSALTPGDSTPANGTVYDIEDEDDASRLLPIGPAQADSPEWQATIEEVVKSVVSIHFCQTCSFDTELSMSSQATGFVVDAERGYILTNRHVVCPGPFWGYCIFDNHEECDVRPVYRDPVHDFGILKFDPKAIRYMNLTELKLQPDAARVGSEIRVVGNDAGEKLSILSGVISRLDRNAPEYGEGYSDFNTNYIQAAAAASGGSSGSPVVNIDGHAIALQAGGRADGAATDYFLPLDRPLRALECIRRGEPVTRGTIQTQWILKPFDECRRLGLTPEWEATVRKAAPTETSMLVAEIILPEGPADGKLEEGDVLLQVNGELLTQFIRLDDILDSSVGQTVRLLVQRGGQDVEIECQVGDLHAITPDRFVTVAGGTFHDLSYQQSRLYAIATRGVYVCEAAGSFKLENTLSGWLIDSVDKRPTRNLDEFVEVMKTIPDRSRVVISYRHIRDLHTRGTSIVYIDRHWHPKMRLAVRNDETGLWDFSDLADALPALPPVPRKADFIQLDGVSQPAASEIVRSFVRVSCTMPLKLDGYPQAKKTGFGLVVDAEKGLVVVSRAIVPYDLCDINITVADSIIVNAKVVFLHPLQNYTIIQYDPSLVQAPVQSAKLSTEYIKQGQDTIFVGFNQNFRIVVAKTAVTDITTVSIPANASAPRYRAINLDAVTVDTGLSGQCSNGVLIGEDGVVQALWLNYLGERTPSSHKDVEYHLGFATPSLLPVVSKIQQGVMPELRILNMESYVVQMSQARIMGVSEEWIEKVTQANPSRHQLFMVRKVDCPPAGFDNMADTFQEGDILLTLDGQLITRVSELDVMYDKEFLEALIVRNGQEMRIQVPTVPTADLETDRAVVFCGAVLQKPHHAVRQQISKLHSEIYVSARSRGSPSYQYGLSPTNFITAVNGVPTPDLDRFVKEVSKIPDNTYFRLRAVTFDNVPWVVTMKKNDHYFPMSEYLKDPSQPCGWRTVSHNKSKHKDGIAPDAANLNPDAMEQGYDGASDIEPEAE
What is the function of this protein?
Nuclear serine protease which mediates apoptosis.
What are the official names of this protein?
Pro-apoptotic serine protease nma111.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPB_HYDCU
Sequence: MPLQVKYLGLQPYESTWEAMQRFTNERTEHTPDELWVVEHPPVFTQGLNGQAKHLQAFALEQNIPIIQTDRGGQVTYHGPGQIIIYVLLDLKRAQLGVRDLVHRMEKAIIEFLCDLSISADARPDAPGVYVDGQKIASLGLKIRKQKSYHGLALNFDMDLTPFSWITPCGLEGIQMTQVSHFIQQPDQLASQTALIKALCHQLQPEIDS
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_YERPA
Sequence: MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPALSAQLTAIGHRIVHGGEKFTSSVIVTEDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEESYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVMGTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTALMDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRAR_STAAW
Sequence: MQILLVEDDNTLFQELKKELEQWDFNVAGIEDFGKVMDTFESFNPEIVILDVQLPKYDGFYWCRKMREVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFYTNVLIAKLQAIYRRVYEFTAEEKRTLTWQDAVVDLSKDSIQKGDDTIFLSKTEMIILEILITKKNQIVSRDTIITALWDDEAFVSDNTLTVNVNRLRKKLSEISMDSAIETKVGKGYMAHE
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs) (PubMed:25287929, PubMed:26597988).  Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis (By similarity).
What are the official names of this protein?
Response regulator protein GraR, Glycopeptide resistance-associated protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_CLOB1
Sequence: MSGKILDKMAGLLGLEDDLEEDLEEVEEETAEEEVTPLISSNTKRNNKVVSIHTAVSAKVKIIKPCSYEEAVDICDELKNRKIIIVNTTDLETKIAQRLLDFMGGASYALGGSLEEVEKSVYILAPSTVEVTNELKSQLISSKGIFNWNK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RECR_ECOSE
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PURR_SHIFL
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: MSHB_MYCBP
Sequence: MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVHVVTCTLGEEGEVIGDRWAQLTADHADQLGGYRIGELTAALRALGVSAPIYLGGAGRWRDSGMAGTDQRSQRRFVDADPRQTVGALVAIIRELRPHVVVTYDPNGGYGHPDHVHTHTVTTAAVAAAGVGSGTADHPGDPWTVPKFYWTVLGLSALISGARALVPDDLRPEWVLPRADEIAFGYSDDGIDAVVEADEQARAAKVAALAAHATQVVVGPTGRAAALSNNLALPILADEHYVLAGGSAGARDERGWETDLLAGLGFTASGT
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: CT51_CONCB
Sequence: MRCVPVFIILLLLASPAASDPLEKRIQSDLIRAALEDADTKNDPRILEDIVSTALATCCKFQFLNFCCNEK
What are the official names of this protein?
Conotoxin Ca5.1, Ca-92.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OFT11_ARATH
Sequence: MKSKIHHQPNGSNNGVVSSNDNGCRSESPSPPLSPNRRVLRRQRRQTLLRASSFSLRRNLRYLLLLPMIYASGLLMCVGPFSGLVGWVYVPGSVYRSPEIYRKLKDDIFSDNSTALELSSVWKFKRRPKMPKPCPNSTVSSHFGLNRESSALAPSSGYLIVEANGGLNQQRSAICNAVAVAGLLNAVLVIPRFEFHAIWKDSSNFGDIYDEDHFISSLEGYVKIVRDVPDEIMTRFSYNVSSIPTIRVQAWATVNYYNGEVYPVLKEHGVIRITPFANRLAMSVPPYIQLLRCIANYKALKFSSPISTLAEKLVDRMVEKSSATGGKYVSVHLRFEEDMVAFSCCLYEGGRAEKSEMDVIRQKSWKGKFKRRDRVIRPDLNRVNGKCPLTPLEVGMMLRGMGFDNNTSIYLASGRIYQPEKHLAPLQEMFPRLYTKESLATPEELAPFQGYSSRMAALDYTVSLLSEVFVTTQGGNFPHFLMGHRRFLFGGHAKTVIPDKPKLVLLLQDMEMRWEVFKKEMKLMLGESDRKGVMVPRVRKINRKTSIYTYPLPECECIFHLSSNFSNTGNILSLGALHPSSNLISSARL
What are the official names of this protein?
O-fucosyltransferase 11, O-FucT-11, O-fucosyltransferase family protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase GT106 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: GCST_LYSSC
Sequence: MTNELKRTPLFEEYAKYGAKTVDFGGWELPVQFSSIKDEHDAVRNRAGLFDVSHMGEILVTGPDALNFLQNLLSNDVSKIATGQAQYTAMCYENGGVVDDLLTYKLADDHYLLCVNAANIEKDYDWMLENQHQYDVTIDNQSDAYAQIALQGPLAEEVLQSLTSTDVSAIKFFRFQENVEVTGHKVLVSRSGYTGEDGFELYGAPEDIKALWGKILDAGQDKGVVPAGLGCRDTLRFEAGLPLYGQELSATISPLEAGIGFAVKLNKEDFIGHDALVAQKENGLPRKLVGIEMIDKGIPRHGYKVFKDGKEIGEVTTGTQLPSSKRNVGHALIDSQFATIGNEMEIEIRGKQLKVVTVETPFYKRSK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: ENGB_NITHX
Sequence: MTTGADADLIERGRKLFAGDWQFIWASPSIETLPPMAGVEVAFAGRSNVGKSSLINALTGRGTLARTSRTPGRTQELIFFEGPKDADVRLVDMPGYGFASAPKARIASWTSLIHKFLLGRASLARVYVLIDSRHGIKDIDQAILTTLDRSAVSYQIVLTKADEVKATEMAERTEATRTLLAKHPAAFPDVLVTSSRTGYGVPELRAAMARLIGEHQR
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.