PharMolix/UniProtQA huggingface dataset:
Protein: CAPSD_BPN4
Sequence: MLNYNAPTDGQKSSIDGANSDQMQTFFWLKKAIITARKEQYFMPLASVTNMPKHYGKTIKVYEYVPLLDDRNINDQGIDASGATIVNGNLYGSSKDIGNITSKLPLLTENGGRVNRVGFTRIAREGSIHKFGFFYEFTQESIDFDSDDGLMEHLSRELMNGATQITEAVLQKDLLAAAGTVLYAGAATSDATITGEGSTPSVVSYKNLMRLDQILTENRTPTQTTIITGSRMIDTKVIGATRVMYVGSELVPELKAMKDLFGNKAFIETQHYADAGTIMNGEVGSIDKFRIIQVPEMLHWAGAGAQATGANPGYRTSMVSGQEHYDVYPMLVVGDDSFTSIGFQTDGKSLKFTVMTKMPGKETADRNDPYGETGFSSIKWYYGILVKRPERLALIKTVAPL
What is the function of this protein?
Assembles, to form an icosahedral capsid with a T=9 symmetry, about 60 nm in diameter, and consisting of 535 capsid proteins.
What are the official names of this protein?
Major capsid protein, Gene product 56, gp56, Major head protein.
What are the subcellular locations of this protein?
Virion. Note=Present in about 548 copies in the virion.
Protein: MUTS2_STRZT
Sequence: MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASRELQSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHATEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVHFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADRGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDIFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: FRI2_MAIZE
Sequence: MMLRVSSSPAAAVANHLSGGAAATTAPARVTAQRSGVSLSAAAAAGKGKEVLSGVVFQPFEEIKGELALVPQSPDRSLARHKFVDDCEAAINEQINVEYNASYAYHSLFAYFDRDNVALKGFAKFFKESSDEEREHAEKLMEYQNKRGGRVRLQSIVAPLTEFDHPEKGDALYAMELTLALEKLVNEKLHSLHGVATRCNDPQLIDFIESEFLEEQGEAINKVSKYVAQLRRVGNKGHGVWHFDQMLLQEAA
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
What are the official names of this protein?
Ferritin-2, chloroplastic, ZmFer2.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid.
Protein: CADH6_BOVIN
Sequence: MRTYRYFLLLFWVGQPYPTFSTPLSKRTSGFPAKKRTLELSGNSKNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRKTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITEGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPHVEPRFLYLGPFKDSATVRIMVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNPPEFAEFYETFVCEKAKADQLIQTLRAIDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGIFTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHQGNMQSCHAEALVHPTGLSTGALIAILLCIVTLLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDSKLRRDIVPEALFLPRRTPAARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGAGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGVDSDKDS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).
What are the official names of this protein?
Cadherin-6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: Y1295_AQUAE
Sequence: MMKEETRTGIGLKDVSIRLVSESPLLPVGGFVYCEYGIPVRYLKIDENEVKLEISVEKLKNLSRVCENIEQVVDKVVEELRYALPEGVFTIAKVYANGIKLRELSYLEEYTSVGKGIIIDEDRELDQEMPAYVKENRETILGTIREVILLELMYSS
What are the official names of this protein?
Uncharacterized protein aq_1295.
Protein: DDL_GEOTN
Sequence: MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEEVKQLQFTSTATAMIPVSLNQVPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLNLPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKYEWKKGGEAVYDRIEQELGYPCFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPICSVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVDFFLAEDGTVYINEVNTMPGFTPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITYTFEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPM_ECODH
Sequence: MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: PNP_LEPIN
Sequence: MTHTISGQYGRDTIVLETGSWAKQAHGAVVYKSGNLVLLATVCAADEAKEGQDFFPLTCEYTEKLYSVGRFPGGYFKREAKPPEHEILISRIIDRPIRPLFPEGYFCEVQLQVQVLSADGDVSVAGHALNAASAALAVSDIPFNGPIAGARIGRVNGELILNPTTKEILNSDLDLVVAGTKTHIVMIEGEAKELSNEEMIAALRFAQKHIAEFVTLQEEYAKKIGVVKREVKLKVRDEELLSKVKEYAFAKLTTANQTPDKTARNKEISNVNKEVVEFFKDTIEDSDKIKDIKAYLHELEYEIVREQVLTKGTRFDGRKLDEIRSISVEINPLPGPHGSAVFTRGQTQSLGVVTLGTGSDNQRYETLEGQKEKSFMLHYNFPAFSVGEVRRSSGPGRREIGHGNLAERALKLVLPKPDEFPYVIRVVSEILESNGSSSMASVCSGSLALMAAGVPIQGSVSGIAMGLFSDSSGKYAVLSDIAGLEDHFGDMDCKIAGTRKGITAFQMDLKVTGVSFDVLESVFEQAQRGRFHILDIMEKHISKASSTLAGTAPRIIVRNIPKDRIGELIGPGGKNVRGISELTGAELYIEDDGKVTISGSNQESAEKAAKMVDGFFAEVEVGKIYEGKVKRIADFGAFVEILPGKEGLCHISKIDFKRVNSVKDIVKEGDIIRVKVLNVDKTGKIDLSRKDALEEEQV
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB2A_ANAIN
Sequence: MVADAVAKVCGSEAIKANLRRSWGVLSADIEATGLMLMSNLFTLRPDTKTYFTRLGDVQKGKANSKLRGHAITLTYALNNFVDSLDDPSRLKCVVEKFAVNHINRKISGDAFGAIVEPMKETLKARMGNYYSDDVAGAWAALVGVVQAAL
What are the official names of this protein?
Globin-2 A chain, Globin II A chain, HBII-A.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: GSA_PYRNV
Sequence: MLFERARGVFPGGVNSPARALKHLAAPLVANGASGPYLYTDRGRLVDYCMAFGAIILGHAHPRVKNAVAKQLERGWIYALLTEEEVAYAERIKAHVPSIEKMRIVNSGTEATMNAVRLARGYTRRDVIIKFDGNFHGSHDYVLVKAGSGAATWGVPTSAGVPQDVIKLTAVVPYNDVDAFVKAVREVGGRLAAVIVEPIAANYGLIIPDREFIKALREETERAGALLIFDEVVTGFRVGLSGAQGHFGVRPDLTTLGKVVGGGFPIGIFGGRADVMDMVAPSGPVYNAGTYNAHPVSVAAGLAVVEELERGEPYKIANEAAERLARGIEDIAGRVGFDVVVKQIASMFQLYFRRGDVKTPQDVRESDERLYLKLHELAIKHGVYLAPSQYETNFTSAAHTRDVVETTLAALEKAFTELKSQVGK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGD_XANCB
Sequence: MQRRHFLKNAAAALAALGLPALPPWALAAKAVGLRRLGQPQPFDYAWLKGQARALAKAPYKSHKQVLPGPLESLNWDQYQSIRYRQDHALWADGNGKFQAKFFHLGLYFHTPVHIYDIVDGKAQQLAYDPAAFDYGRSGLGGKQLPKDLGFAGFRLNTRKDTDRDFSAFLGASYFRAVGKEGQYGQSARGLAIDTGTGGPEEFPDFIAYYLEQPADDSDTVVVYGLLDSPSVSGAYRFAITNGEVLVMDIDSALYPRKAIERLGIGPCTSMYQTGENDRRMDWDWRPEIHDTDGLAMWTGGGEWIWRPLCNPPHLRFNMFVDENPRGFGLLQRDRNFDHYQDDGVFYEKRPCLWVEPKSGWGKGSVQLVEIPTVDETFDNIVAFWNPQAKPQPGQELLMGYRLYWGAHPPASSPLAHCMATRTGLGGIVGQKRSHFSWRFAVDFAGGELAALAKDPKAKVEAVLQVSRGTTEIVSARPLHELKGYRAMFDLVPPDEGTQQIDIRLFLRANGKPLTETWLYQWTPPPASERKIY
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GPMI_PARMW
Sequence: MDQSSGKGSGRDVGVAPVVLTILDGWGHRNDSEHNAIRQGDTPVMEALWHAYPHALIQASGSHVGLPDHQMGNSEVGHLTIGAGRIIRQELVRISDTVRDDQLNNTPALVELAEHLQNDTGTLHLLGLCSDGGVHSHVNHLCGLIHWAAAAGIKKVAVHAITDGRDTPTQSAMGSITLVQRAMEEAGVGHLASLCGRYWAMDRDKRWDRTEKAYDLYTDPTRSISDQSPQQLLAESYAAGITDEFLKPVRLSDDVMQDGDSVLVFNFRPDRARQIVQTLCLDDFDGFERRTTPKLDVVTFTQVEQDLPVSVAFPPEPLDDLLGQVVAEAGLRQYRTAETEKYPHVTYFMNGGIEQPLPGEERHLVPSPRVATYDLSPAMSADQLTDSCIDAIDQGTYSLIVINYANPDMVGHTGVMDAATEAIATVDRCIGRLLDAVGRRGGTMLITADHGNAELMQGPDGQAWTAHTTNPVPCILVEGEQRKLPGHGNDISLREDGGLADIAPTLLQILNLEQPAAMTGRSLIEPVSNVDPSPLSARLPLPV
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RNM5_ENTFA
Sequence: MKVAEIIVVEGKDDTRRIQEVVAADTIETIGSAINDEILTQIEHAQETRGVIIFTDPDYSGEKIRKTIMEVVPDAKHAFLSRKVAVPKKNGGSLGVEHASDEAIIEALKKVVTPVQADEDYQEIPRQTLVEYGLIAGANAKKYRELLGDDLRIGYTNSKQLVKRLSMFRITEAELKESMTRILKELANEE
What is the function of this protein?
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor.  Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
What are the official names of this protein?
Ribonuclease M5, RNase M5, Ribosomal RNA terminal maturase M5.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease M5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSEB_SALTY
Sequence: MSSGNILWGSQNPIVFKNSFGVSNADTGSQDDLSQQNPFAEGYGVLLILLMVIQAIANNKFIEVQKNAERARNTQEKSNEMDEVIAKAAKGDAKTKEEVPEDVIKYMRDNGILIDGMTIDDYMAKYGDHGKLDKGGLQAIKAALDNDANRNTDLMSQGQITIQKMSQELNAVLTQLTGLISKWGEISSMIAQKTYS
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.  SseB is required for correct localization of SseC and SseD on the bacterial cell surface.
What are the official names of this protein?
Secreted effector protein SseB, Secretion system effector B.
What is the protein family that this protein belongs to?
Belongs to the EspA/SseB family.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Secreted via type III secretion system 2 (SPI-2 TTSS). After secretion, localizes mainly on the surface of the bacterial cell.
Protein: TRUB_STRCO
Sequence: MTEKHTTPDGLVIVDKPSGFTSHDVVAKMRGIARTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTIRLGQTTLTDDAEGEITGSRDASKVTWEAIDAGVAELSGDIMQVPSKVSAIKIKGVRSYKRAREGEEFEIPARPVTVSSFAVYDVRDAVADDGTPVLDLVVSVTCSSGTYIRALARDLGAGLGVGGHLTALRRTRVGPYKLDGARTLDQLQQELTVMPVADAAGAAFPRWGVDARRARLLANGVRLEMPEEYTGVGAVAVFDPEGRLLALVEEHKGKAKSLAVFG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RLMH_CAMFF
Sequence: MQILVHCIQKKDDDFDNIKEYIKMSSKWADIKDINKFNSQIAKAQSASKEQAHKAYDLAYEHCLNGYCIGLDEKGYHLDSVEFADLLKNSSQISFFIGGAYGLSPQFKTKMNRLISLSKMTLAHKIAKLMLFEQIFRGLCINANHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_BURM7
Sequence: MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_THIDA
Sequence: MPTIVEELVRKKCAPCEGGIAPLTDAQVAPMLKGLSGWQRDGIKIVKEYKFKDHYQAQAFTNAVMWVSHREDHHPYLIVGYNTVKVEFWTHAIEGLSENDFICAAKVDSLLDL
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RL15_SYNR3
Sequence: MSLTLQSLKPQKGARRRKMRKGRGIAAGQGASCGFGMRGQKSRSGRPTRPGFEGGQMPLYRRVPKLKHFTLVNPKRFTVVNVGELAELKAGTVVTRDSLTEAGILTSPKHALKVLGDGELKVKLTVHAAAFTASAREKIEAAGGSCELID
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: NOVA1_RAT
Sequence: MAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGFPYANTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVR
What is the function of this protein?
Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion.  It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons.  Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion (PubMed:12124753).  Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons.  Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion.  With NOVA1, they perform unique biological functions in different brain areas and cell types.  Autoregulates its own expression by acting as a splicing repressor.  Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.  Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord.
What are the official names of this protein?
RNA-binding protein Nova-1, Neuro-oncological ventral antigen 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SE1L3_MOUSE
Sequence: MQWRGAGLWWPRRRQQQQQQQPPPPAFGPPAAAMVPPSRGVSPGLGGRPTSALLFLCYLNFVPSLGRQTSLTTSVLPRTEQSTTYADFIYFTAFEGSVRNVSEVSVEYLCSQPCVVHLEAVVSSEFRSSIPVYKKRWRNEKHLHTSRTQTVHVKFPSIMVYRDDYLIRHPISVSTVILRAWITHWHSGGGLNVRGEENLLHAVAKNYTLLQTVPPFERPFKDHQVCLEWNMDYLWSLWANRIPQCPLESDAVALLSFPYASSGENTGIVKKLQNFQNRELEATRSQRVDYPMVTISLWLYLLHYCEASLCGILYFVDSNEMYGTPSVFLTEDGSLHIQMHLVKGEDLAVKTKFTIPLKEWCRLDISFNGGQIVVTASIGWDLKSYHNQTISFHEDFYYNDTAGYFIIGGSRYVAGIEGFFGPVKYYRLRSLHPAQVLNPFLEKELAEQIKLYYERCTEVQDIISSYAATVQVGGERRETCDFHNSYLDLKRKYGRAEVCRGLPWEKELRDRHPSLFQSLLQMDLLTVPWNQNDSVLEIGARIFEKAVKRLSGVDGLHQISSAIPFLMDSSCCGYHKASYYLTVFYETGLNGPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGVDSYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIFPGVPGRNLTLAGEYFHKAAQGGHIEGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGLWHEALLYYVLAAETGIEVSQTNLAHICEERPDLAGRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLAALIEEGAVIPHHILEFLEIDPSLHSSNTSILQELYERCWSLSNEESLSPCSLAWLYLHLRLLWGAVLHSALIYFLGTFLLSVVIAWMVLYLQYISASGSSPAPAWVSADPTSSTPSPAVPPAADASDHDPPMMANGPEPRG
What are the official names of this protein?
Protein sel-1 homolog 3, Suppressor of lin-12-like protein 3, Sel-1L3.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SLYX_XANCB
Sequence: MHEQLSPRDQELEARLVELETRLSFQEQALTELSEALADARLTGARNAELIRHLLEDLGKVRSTLFADAADEPPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: SUCHY_HUMAN
Sequence: MPSETHAMLATLARVAALRRTCLFSGRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFAEPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVVDQHETH
What is the function of this protein?
Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA.  Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.
What are the official names of this protein?
Succinate--hydroxymethylglutarate CoA-transferase, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family.
Protein: SMG_ECOLI
Sequence: MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFEREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDNAEFELDDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: TRPF_CHLT2
Sequence: MKVKICGITHPDDAREAAKAGADYIGMIFAKDSRRCVSEEKAKYIVEAIQEGNSEPVGVFPEHSVEEILAITEATGITSIQLSGEDILFKFSQLREHFSIFYVVSVYSNGQPSAALPPMNDAVTVVYDHIGGERGSPFDWKAFSPFQHNNWMLGGGVNLWNIKEGISLLNPRGIDVSSGVERPGILRKDIFLMQALINSAKELSSSTL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: AROB_LACPL
Sequence: MTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDELTAAGFKVRVMTVPAGEESKSWSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASIYMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSFYQPDLVVIDPAILVTLPPRMLAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQRQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAVGLPTELPPIAPQAVAAVMQHDKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSVS
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRIP1_HUMAN
Sequence: MSPVHRSRTSQTQEAHKPTSTLSFISPPQPPRQDPKSPHILCSQPNACSRQSHVSYPNPWGLPCSQSKVSPPGTATNPNPKEWSRISGPPVSLDPQPWSSAPFKPTAQLPLLAQSLGPPAKPALPDPALPLQML
What are the official names of this protein?
Putative protein KRIP1, Kallikrein-related in prostate protein 1, Kallikrein-related mRNA protein, KARMA.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEL_VESMC
Sequence: MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG
What is the function of this protein?
Main toxin of bee venom with strong hemolytic activity and antimicrobial activity.  It has enhancing effects on bee venom phospholipase A2 activity.  This amphipathic toxin binds to negatively charged membrane surface and forms pore by inserting into lipid bilayers inducing the leakage of ions and molecules and the enhancement of permeability that ultimately leads to cell lysis.  It acts as a voltage-gated pore with higher selectivity for anions over cations.  The ion conductance has been shown to be voltage-dependent.  Self-association of melittin in membranes is promoted by high ionic strength, but not by the presence of negatively charged lipids.  In vivo, intradermal injection into healthy human volunteers produce sharp pain sensation and an inflammatory response.  It produces pain by activating primary nociceptor cells directly and indirectly due to its ability to activate plasma membrane phospholipase A2 and its pore-forming activity.
What are the official names of this protein?
Melittin, MEL, MLT.
What is the protein family that this protein belongs to?
Belongs to the melittin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Alpha-helical peptides form toroidal pores in the prey.
Protein: ECTD_STRAQ
Sequence: MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPVAAKDLQGYEHDGFLTVDQLIAPDEVAVYQAELNRLISDPAVRADERSIVEKQSQNVRSVFEVHRISEVFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGATGFYWHSDFETWHAEDGLPNMRTVSVSIALTENFDTNGGLMIMPGSHKTFLGCAGETPKDNYKKSLQMQDAGTPSDEALTKMADRHGIRLFTGRAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENAAQEPFAAPIRRPEFIGARDFTPVK
What is the function of this protein?
Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte.  Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
What are the official names of this protein?
Ectoine dioxygenase, Ectoine hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PhyH family. EctD subfamily.