Protein: ARMB_ARMME
Sequence: MSPSLVVPVFAGHGTTAINSTSLRERAVTDASSSSGALLLDACYYAFNVELSTLSPSEASAVGINPDHFKDPKSLLLLPSHEHYFTNSVVTAATLFLVQTLRYLASVQASSSASFASTLQMNSEHGLGIVGFSSGILPACVVGSSETTLEFISNAVETFRLAFWIGVRLQVHKASVETPELLGESPLPWSLAFLSMSPAAAESAIQSFHKSFEGTPELRVTSVVSETSVTISGRPDILAAFAAQLPPSGPVHKTTVDALYHSSSHHDGVRSQVLADVIRRNIRFPTHADIKIPVRSTYSGELLNKSPEGSASFVEQVIDMILTQPVNWDKVTEALVRAAPEAEVVHLLNFGPGAGLTKGIERYFPSGKVSSIDLSTEAVHTSTLQMPSSVQEPIAICGMSVNMPGAQSVAKLWEVLEKGINTVSEVPEHRFKVSDYNDPKKKSRTMAAHTGNFIDEPDAFDNKFFNISPREARSMDPQQRVLLHTAYEALEDAGYVPNSTPTNNPETFGCYVGVATNDYVQNLRNDIDVYYSTGTLRAFLSGRISYALQFSGPSIVVDTACSSSLIAVYQACRALMNRDCNAAVAGGVNVIGSPDMFLGLDRGHFLSPTGQCKAFDASADGYSRSEGCGIFVLKRLSDAVAENDQILGVIRGVEVNQSGNAYSITRPHAPTQENLFTQTLERSGLDASRISVVEAHGTGTQAGDPIELESIRGIFAKNRKTNNPLHITSVKANIGHLEAASGAAALAKLLLMLRHRTIPRLISLKNLNPRIKPLASDNVIIDTKQVAWAVPDESLPRVALLNNFGAAGSNGALLLEEYIPKSSEKIEVSSTFIVGLSAKNEQALVDLRASYIEYLRSPASAGVSLADIAYTATARRRIFSHRFAVTVKSKEELAHKLELASGKTVSDKAPGKVVFVFSGQGGQYLGMGSALYKTSTLFKSAIDECEYFLKKNNFPGVLPIITSDGESSELTPVEEFEANQAAIFALEYGLAKLWMSWGVTPTAVVGHSLGEYAAHVVAGVLSLESALTLVAHRVRIMMRTCELDTTGMIAINLGSGAVTDILSSSPDFSGISIACYNSATDCVASGAIGQLDALKAHLDKNVHCKSVRLKVPFGYHSSAMQPLLEEFGALAKRVTVHAPKIPVISNPLGRVVREGDKSAFNAEYYLSHCADPVQFESGISALIDDVSFMDIAAWIELGPHPTTLPMLTVHPGVSKEALLVGSLKKRQDDNLTLSSSLSQLYTSNVPVQWRDVFADVSAACVSLPSYPWQKSKFWVAWKEDSPAPASSTEGSPAPTKAFNPVNDFGMLQSWAQFPSAANSQTAIFETPISLLKTSITGHIVGDVPLCPASVYHELALAGIEASKAHLSLPLQGSHSALFNIDYVKPLVYSKDVARVVKTTIAMNTDGSGTFTVESYADSEPESVHCSGQFRPLLVADTTTKFNRMAPVVSRRTAAICSGEDDEAEVITTRTAYEIIFTRVVRYAKEYHTMKNVTISKNGMEGYAIVKLPKDHDRSKFVVHPVFMDTMLHVAGFLANMQGGDNDAYICSKVKSVKAVPSLINNDATYGVFVVNAWVESEGIMLSDAIAVDISEHGQIVAQLKGMCFKKLRLNTLQRSLAMHAGHTSPAPAPKRTVAAAPKPKITEVAPALGPRSSPAKRSVDVQNTVLKIIGDTCGIEVSALDVNADLETYGVDSLMSIEILRKFEESFLQMQFDTTIFSTCNNITELVREISSTIGSQAATAVNTPETASTPEPTLQGDAPQSTDVRSILLELISSFTGFEISSFDLNADADSAYGLDKFLFIPLFSKLQSFFPDVTLDPAKPSVCSTIGELLDEVTAQVQAGPSSSSPGIVDTKPMFVSVLGLDESDIQDDTEFETIGLDSLTAIEALHAIQTKYGLELPSNLFELHNTVKAVNQYISSKQPGKSPKPSEEATMDPDKEEDLSDLTPEQVQSVVRVLRLDEVPMSVQKSSSSGSPLFLFHDGSGAVNYLRRLGSVGREFWGFNNPNYATGKPWGSVEAMASAYADYAVKVAGSRPVIFGGWSFGGVVGFEAARQLMRRGVPVKGVVLIDSPFPVDHVPSSNEFMAVTAGAFTRGGRTPIGRMMWKQLQQNAPLLKTYDPRIAGGPYPPLVLLHNQEGIPPDAFLPYPVPRWMSEKGTDPCLLADDWSGLVGASIKVIHLPGTHFTTFATPHLGAVTQALVDGCAYLDEL
What is the function of this protein?
Non-reducing polyketide synthase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols (PubMed:23993460).  The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene (By similarity).  The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (PubMed:23993460).  ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (PubMed:26655762).  The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (Probable).  The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (Probable).  The role of the NAD(+)-dependent enzymes remains unknown (Probable).  Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (Probable).  The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (Probable).  Finally, several halogenase localized outside of the cluster (armH1 to armH5), are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (PubMed:26655762).
What are the official names of this protein?
Orsellinic acid synthase armB, OAS, Melledonol synthase, Melleolides biosynthesis cluster protein armB, Non-reducing polyketide synthase armB.