PharMolix/UniProtQA huggingface dataset:
Protein: TASOR_XENLA
Sequence: MEENKSVAEGKAATGSLKESEETSAQNGELGEPEVQQTLKRTNSTESGGTGQKPPEEAPRRRFQIPRKSRDKRALQVISSGSREFEEILKILHSSYLDANSKASFSYKCARLVHNEFLEKEFTEKRRQLKFDGRLDKELVESYVFLLVDQEQMHSITEKGLHVGHSRMTTLGKPSMGVYLSRYADLLQANPLETGTTGDIFIFKVIKGKMKFVFDHIRNNQMDSFSGNGGLDPVPKHECHVLKNMNAVTALLGYRAFERTQYYFYEYGFDEVLKRPRHVCPYAVMSFGYKDELATRQPPLPTSGPVSFPTERSFDRSSFTLWRGQLLNKGKLLCYASLKSTSGPFIPYRLPERLDLDIVIKIEVIKKSIPAVLFYKETHNKPNEAKHGGIYSRLYEVVEKTRTGSHLQGLLQKIERENLALVKPLDDRGFMFLYFPSPMTSAYASAKTRLLHALFIYHESRLTQPVANVPVPPSFVPESHEFMPEVLTFVPALHFALHKSQSDTSADFNDVVEKHSRIYLKRRAEKLNKFKEYVLKPYDSRLDYKKSLYVAPRIKGHIESALRSYLFGSEAYTIPVDKAKEMLKENQRFQQFSPVSDYEPVEDDHDSNKYNKKCPVSYVETNSEKSSESTDWDIDKINGLINLIQKKKQSKPETDEPSGVGLKRKLDRQSEKAWKHRKCEENVHHDNEPGESAQSLISSLGGQDTDLRQETESLSSECIKMLLEKLADSCIDPAMAESLKTLKQNSTEELPSQKLKNLSQAHDTEREGAGQDQHIVYNDQTTDNQENTTCLSEEAQQAEGSHSDHSVLMEEKILDPPLESASPCPSNTAGNNCPAQGPNSLDLEMHWKLIPIAEANLTEEQLVYVSTEDALPNDPRAGHKRRGSRYSPLHETERQRPRHDRDYCRSLTTPSRTERNMLQSKHCHNGLIENTVLEVYNTFSEQLHDVLKQRDVPYMVPAAPPLLSSDDRVLKLSDCLCEQVSDICVQQYVDDLHTTLDSVVAAHINSCAVSRTGSPVTEIMAATEVHTFHPKQTVTEYPHVHEHFHVNDLHSDVREANPFSADHVYKVGEENAANGHALSHNSRDLSQETPEISTSGVTDLSEPHLAISNLINQMNPEVFNNLVKIITHVNKNSVKFYVHTEEENAICQNIKEYLLKLGNTECRPEKFLESKTKADKLLIIIQNEDIPNCIHRVPALVLLKRLPSVSFAGVDSLDDLKNHTYNEIFVSGGFIVSDESVLNPETVTIDELKKFLMFLEEINSPDANWQWKIHYKFHKRLKELGRLNTNALNILTLLTTYQKKNLVEILSYHLSCDPQNQQAPQLECLIKLQVQYMKQRHVLFLTEKDAARFPDYCDNGIVVTRMVDFMDNFSNLIGHHSPNNEEQRLSQLTNQGDETAPGEADSKEEEDMSLDSEDDTPPIEVCTDSWKPESQKQNISSLLELVDKDQTESPSTLNQGKTPTLDELQPITPVSVAGSTTGENSVSTGDELGSNTKDYNREVNLSHQFSHFSLLTHQTFLGSMYPTLTNPSQAEICFMNSYSQLTEPETSKNSERKQK
What is the function of this protein?
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression.  The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting further deposition of H3K9me3.
What are the official names of this protein?
Protein TASOR, Transgene activation suppressor protein.
What is the protein family that this protein belongs to?
Belongs to the TASOR family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to chromatin.
Protein: RS15_HELPG
Sequence: MALNLEKKQEIIKAFATKENDTGSCEVQVALLNERIKLLTEHLKANPKDHSSRLGLLKLVAQRRNLLKYIKRTAHARYVVLIEKLGIKDR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PID_ARATH
Sequence: MLRESDGEMSLGTTNSPISSGTESCSSFSRLSFDAPPSTIPEEESFLSLKPHRSSDFAYAEIRRRKKQGLTFRDFRLMRRIGAGDIGTVYLCRLAGDEEESRSSYFAMKVVDKEALALKKKMHRAEMEKTILKMLDHPFLPTLYAEFEASHFSCIVMEYCSGGDLHSLRHRQPHRRFSLSSARFYAAEVLVALEYLHMLGIIYRDLKPENILVRSDGHIMLSDFDLSLCSDSIAAVESSSSSPENQQLRSPRRFTRLARLFQRVLRSKKVQTLEPTRLFVAEPVTARSGSFVGTHEYVAPEVASGGSHGNAVDWWAFGVFLYEMIYGKTPFVAPTNDVILRNIVKRQLSFPTDSPATMFELHARNLISGLLNKDPTKRLGSRRGAAEVKVHPFFKGLNFALIRTLTPPEIPSSVVKKPMKSATFSGRSSNKPAAFDYF
What is the function of this protein?
Serine/threonine-protein kinase involved in the regulation of auxin signaling.  Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing polar auxin transport.  Phosphorylates conserved serine residues in the PIN auxin efflux carriers.  Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis.  Acts in association with PIN1 to control the establishment of bilateral symmetry and promotion of cotyledon outgrowth.  Regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport.  Required for polarization of PIN3-dependent auxin transport for hypocotyl gravitropic response.  The protein kinase activity of PID is essential for its auxin efflux regulatory function.  PID kinase and PP2A phosphatase activities antagonistically regulate phosphorylation of PIN proteins, affecting PIN sorting.
What are the official names of this protein?
Protein kinase PINOID, Protein kinase ABRUPTUS.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Targeted to the cell periphery.
Protein: ACTPA_OULOR
Sequence: ATFRVLAKVLAELGKVSRKIAVGVDNESGGSWTALNAYFRSGTTDVILPDLVPNQKALLYRGGKDTGPVATGVVGVLAYAMSDGNTLAILFSVPYDYNLYSNWWNVKVYSGKRRADQGMSEDLSYGNPYGGDNGWHARKLAYGLKERGFMKSSAQSILEIHATKA
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.  Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts.  Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.
What are the official names of this protein?
DELTA-actitoxin-Oor1a, DELTA-AITX-Oor1a, Actinoporin Or-A, Cytolysin Or-A.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: AIP12_ARATH
Sequence: MELSETYACVPSTERGRGILISGNSKSDTILYTNGRSVVTLDLNNPLKVSIYGEHAYPATVARYSPNGEWIASGDVSGTVRIWGAYNDHVLKNEFKVLAGRIDDLQWSADGMRIVASGDGKGKSLVRAFMWDSGSNVGEFDGHSRRVLSCAIKPTRPFRIVTCGEDFLVNFYEGPPFKFKLSSREHSNFVNCVRFAPDGSKFITVSSDKKGIIYDGKTCEILGELSSDDGHKGSIYAVSWSPDGKQVLTVSADKSAKIWDISDNGSGSLNTTLNCPGSSGGVDDMLVGCLWQNDHIVTVSLGGTISIFSASDLDKSPFQFSGHMKNVSSLAVLKGNADYILSGSYDGLICKWMLGRGFCGKLQRTQNSQIKCFAAHEEEIVTSGYDNKISRISYKDDQCTNEESIDIGNQPKDLSLAPLSPDLLLVTFESGVVFLRDGKVVSTINLGFIVTALAVTPDGTEAVIGGQDGKLHLYSINGDSLTEEAVLERHRGAISVIRYSPDLSMFASADLNREAVVWDRVSREMKLKNMLYHSARINCLAWSPNSTMVATGSLDTCVIVYEVDKPASSRMTIKGAHLGGVYGLGFADDSHVVSSGEDACIRVWSFTPQ
What is the function of this protein?
Binds actin.  Enhances the F-actin depolymerization activity of actin-depolymerizing factor (ADF) proteins.
What are the official names of this protein?
Actin-interacting protein 1-2.
Protein: Y3642_PARXL
Sequence: MPSFDVVCEANMIEVKNAIEQSNKEISTRFDFKGSDARVEHKENEITAYADDDFKLGQVKDVLLSKMAKRNVDVRFLDYGKIEKIGGDKVKQVIKIKKGVSGDLSKKIVRLVKDSKIKVQASIQGDAVRITGGKRDDLQSVIAMLRKDVTDTPLDFNNFRD
What are the official names of this protein?
UPF0234 protein Bxeno_A3642.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RL24_BACAN
Sequence: MHVKKGDKVQVITGKDKGKQGVILVAFPKQNRVIVEGVNIVKKHSKPSQLNPQGGIITKEAPIHVSNVMILDPKTGEPTRVGFKVEDGKKVRIAKKSGELLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RL16_AFIC5
Sequence: MMQPKKTKFRKAHKGRIHGVASSGATLSFGQFGLKAMAPERITARQIEAARRALTRHMKRVGRVWIRVFPDVPVSKKPAEVRMGSGKGSPELWVVRVKPGRILFEIDGVNDQIAREALTLAAAKLPIKTRFVARIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: FRPD4_MOUSE
Sequence: MDVFSFVKIPKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV
What is the function of this protein?
Positive regulator of dendritic spine morphogenesis and density.  Required for the maintenance of excitatory synaptic transmission.  Binds phosphatidylinositol 4,5-bisphosphate.
What are the official names of this protein?
FERM and PDZ domain-containing protein 4, PDZ domain-containing protein 10, PSD-95-interacting regulator of spine morphogenesis, Preso.
What are the subcellular locations of this protein?
Cell projection, dendritic spine.
Protein: HIS1_ANOFW
Sequence: MLTVAMPKGRIFSEALALLKQAGYDIPDDLEHSRKLMIDVPSEQLRFILAKPMDVVTYVEHGVADVGIAGKDVLLEEERDVYEMLDLRISPCYLAVAGLPNTHVHPIAPRVATKYPNIASTYFREQGEQVEIIKLNGSVELAPLIGLAERIVDIVSTGRTLKENGLVELERIVDVTSRFIVNPVSYRMQDRAIERMVDRLTYAIEKVGENDEN
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPOR1_IPOBA
Sequence: MKALTLALFLALSLYLLPNPAHSRFNPIRLPTTHEPASSETPVLDINGDEVRAGGNYYMVSAIWGAGGGGLRLAHLDMMSKCATDVIVSPNDLDNGDPITITPATADPESTVVMASTYQTFRFNIATNKLCVNNVNWGIQHDSASGQYFLKAGEFVSDNSNQFKIELVDANLNSYKLTYCQFGSDKCYNVGRFHDHMLRTTRLALSNSPFVFVIKPTDV
What is the function of this protein?
Major tuberous root protein.
What are the official names of this protein?
Sporamin A, Clone PIM0335.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Vacuole.
Protein: KU_BPMOM
Sequence: MRAVWTGAVNFGLVNVPVKMYAATEEHDLKGHLAHVQDGGRIRYHKVCETCGEQVHTADLGKVFEVDGQTALLTDEDLAELPSENNKVIDVVEFVPAGEVDPILLDKPYYLNAEGSVRPYALLARTLSDADKVAIVRVTLRSKEHLAVLRVTGKNEVLTLQTLRWPDEVREPDFPKLDNKPELSEAELKVAAMLVDELSAPFNPDKHQDTYKVELRALVESKLEPVEVPEDVSGLLAKLEASVKPKQAKPDIRTWAKAQGFKISARGRIPKDIVDKYEGAMA
What is the function of this protein?
Required for replication of viruses with short cos ends (4 bases).  Stimulates dsDNA end-joining by host LigD; in conjunction with M. smegmatis or M. tuberculosis LigD can reconstitute NHEJ in S. cerevisiae.  Binds dsDNA with either blunt, 5'- or 3-overhangs, protecting it from host exonuclease degradation.
What are the official names of this protein?
Protein Ku, Gp206, Omega-Ku.
Protein: RL22_STRPN
Sequence: MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTPNKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINKRTAHITVAVAEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y1670_STRMU
Sequence: MFEKKKRLGLIVYLYYNRDARKLNKYGNVVYHSRRMRYSVLYIAQDETDKIIEEIGALKFVKKVLPSYIDTIDQNFVGSLMR
What are the official names of this protein?
UPF0298 protein SMU_1670c.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP83_BP186
Sequence: MSIRIEIGDKWVITSDQYQFILNEKKVVKTGNKAGEEWLDTIGYYPKINQLISGLVHHHIHTAMIISLSAMAEEIEKLSFICEEAFKAVKK
What are the official names of this protein?
Uncharacterized 10.4 kDa protein in GpA 5'region.
What is the protein family that this protein belongs to?
To phage P2 ORF83.
Protein: AP4AT_HUMAN
Sequence: MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISHESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAAAFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPHSTLQGFGYSKEHGRTAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSRVSDSGSHSGSDSHSGASREPGDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSREEAQHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSSDLLPQEHILLRTRPWLQELSMGSPGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAVPLPGSQVFLQPLSSTPVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAESRRWRPERIPGGTDSPKRGPSSCAWSRDSLFAGMELVACPRLVGAGAAAGESCPDAPRAPQTSSQRTAAKEPPGSEPSAFAFLNA
What is the function of this protein?
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
What are the official names of this protein?
AP-4 complex accessory subunit Tepsin, ENTH domain-containing protein 2, Epsin for AP-4, Tetra-epsin.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network.
Protein: PP4R2_MOUSE
Sequence: MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSPNYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSKDSELQLSEEKGHSDSSASESEVSLLSPVKNKHPDEDAVESEEHEVKRLKFDKEGDVRETASQTVSGEVSSVRAEETETAAPPPDKDRESRTRQHCTEEEEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDALTVNEETSEESHQMEGSGVSPAQTDSTSERSDSAGASRSGSDCLETQESGGPPSSKTGESVSVPSSMESEEATEVTDDPMEQD
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).  May regulate the activity of PPP4C at centrosomal microtubule organizing centers.  Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs.  The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair (By similarity).  Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner.  RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 2.
What is the protein family that this protein belongs to?
Belongs to the PPP4R2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Protein: TY27_PITAZ
Sequence: KPWERL
What are the official names of this protein?
Tryptophyllin-T2-7, Pha-T2-7, Tryptophyllin-7.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Tryptophillin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS6_STAA2
Sequence: MIKKRIIPCLDVKDGRVVKGIQFKGLRDIGNPVDLAIYYNEAGADELVFLDISKTEEGHSLMLEVIEQTASRLFIPLTVGGGIQSLDDITQLLNHGADKVSLNSSALKNPQLIKQASDKFGRQCICIAIDSYYDPERKAHYCCTHGGKKMTNIKVYDWVQQVEQLGAGELLVTSMGHDGMKQGFDIEHLAKIKSLVNIPIIASGGGGNAQHFVELFNQTDVSAGLAASILHDRETTVQSIKEVIRQGGIAVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_ECO81
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQESWEDAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELADTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLDKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSPLPLVDVDALERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: GTD2B_HUMAN
Sequence: MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVEKSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
What are the official names of this protein?
General transcription factor II-I repeat domain-containing protein 2B, GTF2I repeat domain-containing protein 2B, Transcription factor GTF2IRD2-beta.
What is the protein family that this protein belongs to?
Belongs to the TFII-I family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LDH_BORAP
Sequence: MLKSNKVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNEDKAKGEVMDLNHGQMFLKKNINVLFGTYKDCVNADIVVITAGLNQKPGETRLDLVGKNSKIFKDIITNVVSSGFDGIFVIASNPVDIMTYVTMKYSKFPIHKVIGTGTILDTSRLRYFLSDRFNVNTQNIHSYVMGEHGDSSFVTWDETKIAMKPLSEYLSEGKITELELDEIHKKVVNAAYEVIKLKGATYYAIGLGIKNIVNAIIGDQNIILPISSYINGQYGGLIKDIYIGAPAIVCKEGVKEVLNFKISPKELEKFNNSANQLKSYIDKIEF
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISDA_STAA9
Sequence: MTKHYLNSKYQSEQRSSAMKKITMGTASIILGSLVYIGADSQQVNAATEATNATNNQSTQVSQATSQPINFQVQKDGSSEKSHMDDYMQHPGKVIKQNNKYYFQTVLNNASFWKEYKFYNANNQELATTVVNDNKKADTRTINVAVEPGYKSLTTKVHIVVPQINYNHRYTTHLEFEKAIPTLADAAKPNNVKPVQPKPAQPKTPTEQTKPVQPKVEKVKPTVTTTSKVEDNHSTKVVSTDTTKDQTKTQTAHTVKTAQTAQEQNKVQTPVKDVATAKSESNNQAVSDNKSQQTNKVTKHNETPKQASKAKELPKTGLTSVDNFISTVAFATLALLGSLSLLLFKRKESK
What is the function of this protein?
Cell wall-anchored surface receptor that participates in the extraction of heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (By similarity).  Receives heme from IsdB and transfers it to IsdC (By similarity).  Also plays a role in the inhibition of host immune response.  Protects S. aureus against the bactericidal protease activity of apolactoferrin.  Decreases bacterial cellular hydrophobicity, which renders S. aureus resistant to bactericidal human skin fatty acids as well as to beta-defensins and cathelicidin.  Also binds fibronectin and chains B-beta and gamma of fibrinogen, promoting clumping of S. aureus with fibrinogen.  Involved in adherence of S. aureus to human desquamated nasal epithelial cells and is required for nasal colonization (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein A, Fur-regulated protein A, Staphylococcal transferrin-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the IsdA family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Encodes an LPXTG motif-containing sorting signal that targets to the cell wall, which is catalyzed by sortase A.
Protein: RIMO_PELTS
Sequence: MGIKIGLVSLGCPKNLVDSEIMLGILKKAGYEITAREKEADVLIVNTCSFINDAKEESIRTIIELARNKINGRCRAILVAGCLAQRYPAELMAEMPEIDGLVGTGQVPEIARAVRRVLEGGKVLLTGSPGYLHDAYFPKVLATPPYTAYLKIAEGCDNRCSYCVIPAVRGPFRSRRMEDIMSEAEELANKGVKELIIVAQDTTRYGIDLYGKPMLDALLEGLTGIKGPVWLRLLYTYPSLITDDLIYLMAKSRKICRYLDIPFQHASNRVLQLMNRRGSKEEAARLVAKLRADIPGIVLRTTFIVGFPGETEEDFQELLDFMAEAKFDRAGVFTYSREEGTAAAEMPGQVPEEVKLLRRERAMMLQQEISLQKNLKRVGEVIEVLVEGKSLKGRGMYTGRSEGDAPGIDGKVFFKSGFNLQPGDFARVLIKGGTEYDLTGETVL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_SHESH
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGVNVGIGRDHTLFALTDGKVKFEVKGPKNRKFISIEG
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.