PharMolix/UniProtQA huggingface dataset:
Protein: UBCD2_DROME
Sequence: MSSTPAAGSAAEVATSSATSNAPSAPSTTASNVSNTSQPTTAGTPQARGGRGSNANGGASGSNAGGGDEPRKEAKTTPRISRALGTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2-24 kDa, E2 ubiquitin-conjugating enzyme 2, Ubiquitin carrier protein, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: CXXC1_BOVIN
Sequence: MEGDASDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDSSERDGSEPRDEGGGRKRPAPDPDLQRRAGAGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQPQPQPSQKLGRLREDEGAVASAAVKEPPEATATPEPLSDEDLPLDSELYQDFCAGAFDDHSLPWMSDTEESQFLDPALRKRAVKVKHVKRREKKSEKKKDERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSNAER
What is the function of this protein?
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
What are the official names of this protein?
CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity).
Protein: MTGA_KLEOX
Sequence: MTFRFSARCRLIKRFLLRLLLACAVLWGGGVALFSIVPVPFSAVMLERQLGAWLSGNFHYIAHSDWVGMDEISPWMGLAVIAAEDQKFPEHWGFDVPAIEKALAHNERNENRIRGASTLSQQTAKNLFLWDGRSWLRKGLEAGLTVGIETVWSKKRILTVYLNIAEFGEGTFGVEAASQRYFHKPASRLTAAEAALLAAVLPNPIRFRADAPSGYIRSRQAWILRQMRQLGGEGFMRANQLH
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Monofunctional biosynthetic peptidoglycan transglycosylase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: BIOB_CHLCH
Sequence: MLHPAIESAYRVLATGEPLTHGEALQLANLSGSDLLDLASLAHKVQLRYAGGVESFHACSIMNAKSGVCGENCRFCAQSKHNNAAIEVYDLVSDDSVLIEARQAVANGVSHFGIVTSGYGYQRITPEFERLLGMIDRLHSELPSLNVCASFGVLGEEPVAALAAHGIAHYNINLQVEPNRYNDLIATTHSAEERIATIHRLRQHNIAVCCGGIIGVGESVEERIGLLIALQALDLAVIPLNVLVPIAGTPLEKSEPLSAAEVLKTFAICRLLHPRTIIKFAAGRETMMKDFQGLLMLAGVNGFLTGGYLTTRGRDVADDQRFAAQLASFA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GLMM_SYNE7
Sequence: MVSATRWETAIEVTPWIAAIAEQVPLFGTDGIRGRVGEHLTAPLAQQVGFWTGQVLRQAGGDRGPVVVGQDSRNSSNMLAMALSSGLAAAGVEVLHLGLCPTPGVAYLTHHSEAIGGVMISASHNPPGDNGIKVFGADGSKLDRQLQAAIEAGLRGQQTSLPATTWGQHYYQPQLADHYQAAIAQSLGQRANLQGLKIVLDLAWGAAALLAPRLFRELGAEVIALHDLPDGNQINVNCGSTHLARLQAAVLEQGADMGFAFDGDADRVLAVDGRGRSVDGDHILFLWGRELEQQQQLPGQAIVTTVMANLGFERAWQAVGGEFVRTAVGDQYVQAEMQARGAMLGGEQSGHILCRHYALTGDGTLTAAHVAALVQASGVSLADLVDQSFRPYPQLLRNVRVEDRDRRCNWQNCAALTQAIAAAETDMGDRGRVLVRASGTEPLLRIMVEAEEAQQVEHWTTHLVQVAESHLL
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RS11_LISW6
Sequence: MARKTNTRKRRVKKNIESGIAHIRSTFNNTIVMITDTHGNALAWSSAGSLGFKGSRKSTPFAAQMAAESAAKSAQEHGLKTLEVTVKGPGSGREAAIRALQAAGLEVTAIKDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RL4_NITEC
Sequence: MVKIPCRSENGQVVNIEVSDSVFDRVYNEALVHQIVTSYLANARSGTRAQKGRSEVAGSTRKQWRQKGTGRARVGAASNPLWRGGGKIFPNKPTENFTKKVNRKMYRAGMCTIFSQLLRNSKLVAISEFRVETTKTKFFLQKLKNYQLENVMIITDEVDENLYLASRNVPNIKVVEIDLIDPVSLLSYDNVVITREAVNKIESVLQ
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ACEK_PHOLL
Sequence: MGIDSAHLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKKRINLYDHHVGLVVEQLKCIHSAFGYDEEYIAKVKVVYTGLLPDYPRFEIAESFFNSVYCRLFEHRNLTPDKLFIFTSQPARRFRDIPRPLSRDFFPNDNLALMLRTILNDLPLRLPWENLERDIYYITDYLQQTFPVGELLQATFQIANELFYRNKAAWLVGKIRIGGQVYPFLLPIHHNESGGIFIDTCLTDYADASIVFGFARSYFMVYAPLPAALVEWLREILPAKSTSELYMAIGCQKHGKTEYYREYLAFITFSKEQLIIAPGVKGMVMLVFTSPSFDRVFKVIKDQFAPQKEVTQERVQECYRLVKEHDRVGRMADTQEFENFVIDKARISPELMEELQKEVPEKLEDLGDKILIKHLYMERRMTPLNIYMEQVEERKLKDVIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDELAGEPWYSVAPNDVFPEEFRHFLCTDSRIRRYFEEMHSDLFKADYWRALQERIRSGHVEDVFAYRRKQRFSQRTEIETYSIAKVSA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMPX_SOLTU
Sequence: ASNVPKELVEKGQNRV
What are the official names of this protein?
Unidentified mitochondrial matrix protein.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y1180_SULIM
Sequence: MSYLVVTIKVILITGMPGSGKSEFAKLLKERGAKVIVMSDVVRKRYSIEAKPGERLMDFAKRLREIYGDGVVARLCVEELGTSNHDLVVFDGVRSLAEVEEFKRLLGDSVYIVAVHSPPKIRYKRMIERLRSDDSKEISELIRRDREELKLGIGEVIAMADYIITNDSNYEEFKRRCEEVTDRVLKNG
What are the official names of this protein?
UPF0200 protein M1425_1180.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: NPFF2_HUMAN
Sequence: MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
What is the function of this protein?
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides.  Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands.  This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Neuropeptide FF receptor 2, G-protein coupled receptor 74, G-protein coupled receptor HLWAR77, Neuropeptide G-protein coupled receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HOA_PSES1
Sequence: MTTKKIYISDVTLRDGSHAIRHQYSVEQVRTIAKELDEAKVDSIEVAHGSGLQGSSFNYGFGAHTDLEWIEAVASVVKHAKIATLLLPGIGTIHDLKAAYDAGARIVRVATHCTEADISKQHIEYARHLGMEAVGFLMMSHMSTPQGLAQQAKLMESYGATCCYVVDSGGALSMDDVRMRFRAFKDVLKPETETGIHAHHNLSLGVANSIVAIEEGCDRVDASLAGMGAGAGNAPLEVFIAAAERMGWHHGTELYKLMDAADDIVRPLQDRPVRVDRETLALGYAGVYSSFLRHSEAAAQKYGLKTMDILVELGRRRMVGGQEDMIVDVALDLLKSLEHERIHAQPVSSEAG
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: SC61G_HUMAN
Sequence: MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity).  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).  The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
What are the official names of this protein?
Protein transport protein Sec61 subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
Protein: GPDA_ECODH
Sequence: MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF2_METTE
Sequence: MGRRKKMVERVTTLMNEPEKIRNIGIVAHIDHGKTTLSDNLLAGAGMISKELAGRQLFMDSDEEEQERGITIDASNVSMVHTYNNEDYLINLIDTPGHVDFGGDVTRAMRAVDGAVVVVDAVEGTMPQTETVLRQALREHVRPVLFVNKVDRLINELQVDSQEMQVRLGKVIDHVNKLIKNMNPEKFKAGWKVDAAAGTVAFGSALYNWAISVPMMQKTGISFTNVYDYCKAEDMKALAEKCPLHATVLDMVIRFLPNPLEAQKGRVPTIWHGDANSEIGKSMASANADGDLAFMVTDISIDPHAGEVATGRLFSGSFSRGMEVYISGTARKSRVQQVGIFMGPERLEVEKIPAGNIAAVTGLKDAIVGSTVTTLDGMTPFESIRHVSEPVVTVAVEAKHTKDLPKLVEVLRQVAKEDPTLQITLDEETGEHLMAGMGELHLEVIAHRIQRDKNVEITTSKPIVVYRETIKKKIEPVEGKSPNRHNRFYIYVEPLDTAIVEMIKSGDISMNLPELERRQKLIELGMGKEEAKGIVGIHNSNIFIDITKGIQYLNETMELILDGFEEVMRAGPLTREPVANMKCVLVDAKLHEDAIHRGPAQVIPAARQAIQAGMLMAEDCLLEPYQKVFVQVPQLTMGGATKELQGRRGIILNMTTEGDLAIIEARVPVAEMFGFAGEIRSATEGRAMWSTEFGGFDIVPTSIQTEVVGQIRERKGLKRDLPKASDYLSM
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBHL_RICRS
Sequence: MITKNYLIDKIHDKLNYLSKEDVKDSVDLILDYLNESLKQQKRIEIRNFGNFSIRKRKFPESEKFYNTVYYRMPKNLFKE
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-like.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MFD_MYCTU
Sequence: MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNAB_PROVU
Sequence: MENTSVNKEPSIIVGGFVLGGAMIGAGMFSLPTIMSGAWFINSLFILFIVCFFMFHSGIYILECISKYGAGTNYFDISKELLPKWACYIANASLIFVLYILIYAYISAAGSIIYEASLLYGINFNLRAIFFIFTIALGATIWWGGACASRLTSIFLFIKIVLFILAFSGLFFKAKGDLLFSATFAGKSQLYLYPFIFIIIPYAITSFGYHGNVCSLYKLYNQNERKVVKSCIIGCLLALVIYLLWMIGTMGNLPREQFITIIQKGGNLDAFIDSLYTVLNSKYIEGFLLWFSISAVFCSFLGVAIGLFDYILASLKFKDNKTGRLKSGVLCFTPPLLLCLFFPNGFLIAIAYAGTAACVWAIICPAVMALKARQKFPNSGFKVWGGKKLIYAVIAFGVVGIICQSWRNLIYCLFIVK
What is the function of this protein?
Involved in tryptophan transport across the cytoplasmic membrane.  Plays a role in transporting tryptophan which is to be used catabolically.
What are the official names of this protein?
Low affinity tryptophan permease.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTR1A_HUMAN
Sequence: MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
What is the function of this protein?
High affinity receptor for melatonin.  Likely to mediate the reproductive and circadian actions of melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
What are the official names of this protein?
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PRP28_ASPFU
Sequence: MDGIISNGSPGAPVTQPPPEPLERPPTPPPPPPEDSAAPPPPPDTSVPPPPPEDAPPAPPPEKKKKVGWGAKRPAATPLSVEELVRKKREADAAAAKPKFLSKAERERIALEKRAKEVEAGRRLKLDPFTDGTDRSGTQSPSVYPETPNGDERSIPTGPRAMRNSEVPTGPAAMRNKTYDMSPPPPPKAMSFSLTDGKGDSKRQAEEDEAAAQAALIKQKYMGTEKTSSFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQQRHEANFYGRGRLAGFGDDVADTLAQKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDQVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYISELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEARKFTQPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKQMGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMANSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPNRGLAKKSDDSSGFGTKSGWQ
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase prp28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RUVB_STRE4
Sequence: MTRILDNDLIGDEGSVERTLRPQYLREYIGQDRVKDQLMIFIEAAKRREESLDHVLLFGSPGLGKTTMAFVIANELGVHLKQTSGPAIEKAGDLVAILNDLEPGDVLFIDEIHRMPMAVEEILYSAMEDFYIDIMIGAGDTSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQTADLTEIVERTADIFDMTIKHEAAYELARRSRGTPRIANRLLKRVRDYAQIMGDGMITTQITDKALTMLDVDQEGLDYVDQKILRTMIEVYQGGPVGLGTLSVNIAEERDTVEDMYEPYLIQKGFIMRTRTGRVVTEKAYQHLGYPYEKTIKT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL32_PROM3
Sequence: MAVPKKKTSKGKRNQRHAIWKAKAATAAQRALSIGKSVLSGRAQGFVYPMQESDDDES
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: HMUV_ALIF1
Sequence: MSLSSLAISANNISYRIGSKIILDDINLELRCGEVTTLLGPNGAGKSTLLKLLCDEITSFNDIRYFGKAKDQWDGNELAKRLGVLPQHSTLSFAFNVNEVVELGGLPLSLSNQALREITSNMMQKTVIKHLAERAYPSLSGGEKQRVHLARVLTQVSQHQQKIVMLDEPTSALDLSHQHNTLKLARELASEGAAVIVVLHDLNLAAQYSDRVIVLQDGKLQADGAPWEAITSKMIENVYGHKTLVQAHPTLNFPVVFAA
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RIFK_METMP
Sequence: MEIFGHVVSGLGEGKFFVGLTHYKNKFEELTGFTPFEGTLNVKLKHNFNLDEFNPIEFDGFEIDGKKYFGGKVLLIKLFNKQGNSINCAVVAPKKTDHSKKTLEIIAPIQLRKFLLLKNSDVVKLVI
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: GVPE1_HALSA
Sequence: MDDLLEELTADIDANAAISFAVTDLESVIESDGASDHADQPPDEGATQRYTDTPLTDDAVATMDGWLDNDQLHTISDAIVTEHIDEILLLLITVRDGACGKELLQDLRRLFGADLSPGTVYPHLNDLAVEGVLEVQKLSKRKVYRLSDPEGAFTRIDHMVDQLLLFSLVLKAVMTDCKARQSQSQGRETND
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpE 1.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: RSMA_STRPS
Sequence: MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEIDDQVNVIEIGPGIGALTEFLAERAAQVMTFEIDHRLVPILADTLRDFDNVTVVNEDILKVDLAQHIQNFKNPDLPIKVVANLPYYITTPILMHLIESGIPFSEFVVMMQKEVADRISAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVEDENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLAEFAGLADALKGQGL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_MOUSE
Sequence: MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDASKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L3, J1 protein.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.