PharMolix/UniProtQA huggingface dataset:
Protein: CNDP2_BOVIN
Sequence: MSALTTLFKYVDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADIKQLGGSVQLVDIGTQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLFGRGATDDKGPVAGWINALEAFQKTKQEVPVNVRFCLEGMEESGSEGLDALIFAQKDAFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLIMLMGCLMDKKGKILIPGISEAVAPVTEEELELYDKIDFDLEEYARDVGAGTLLHGCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVSEQVTSYLTKKFAELHSPNKFKVYMGHGGKPWVSDFNHPHYLAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRRNYIEGTKMLAAYLYEVSQLKD
What is the function of this protein?
Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides.  Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity).  Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism.  Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis.  Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity).
What are the official names of this protein?
Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Threonyl dipeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABD_HUMAN
Sequence: MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
What is the function of this protein?
Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1).  This suggests the existence of the biosynthesis of fatty acids in mitochondria.
What are the official names of this protein?
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial, MCT, Mitochondrial malonyl CoA:ACP acyltransferase, Mitochondrial malonyltransferase, [Acyl-carrier-protein] malonyltransferase.
What is the protein family that this protein belongs to?
Belongs to the type II malonyltransferase family.
Protein: SIGF_MYCTO
Sequence: MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIEGLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERERTVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released.  Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase (PubMed:14977982).
What are the official names of this protein?
RNA polymerase sigma factor SigF, Sigma factor SigF, Alternative RNA polymerase sigma factor SigF, RNA polymerase sigma-F factor, Sigma-F factor, Stress response/stationary phase sigma factor SigF.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: PTH_MYCTU
Sequence: MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKRSGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRIRLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVPTICEQAADATELLIEQGMEPAQNRVHAW
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAD_PORPU
Sequence: MPDTINLNMPSPTFGGSTGGWLRAAEVEEKYAITWTGKNESKFEMPTGGTATMRDGENLLYLAKKEQCLALGTQLKGKFKISDYKIYRVFPNGEVQYLHPKDGVFPEKVNAGRASINSVDHSIGKNVNPINVKFTNKATYD
What is the function of this protein?
PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center.
What are the official names of this protein?
Photosystem I reaction center subunit II, Photosystem I 16 kDa polypeptide, PSI-D.
What is the protein family that this protein belongs to?
Belongs to the PsaD family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RISB_PSEPG
Sequence: MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVSESDITIIRAPGAFEIPLVAQKVAQQGAYDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSMEFGVPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GLYA_ACIBY
Sequence: MFANISISEFDPELAQAIASEDERQEAHIELIASENYCSPAVMEAQGSKLTNKYAEGYPGKRYYGGCEFVDVIEQMAIDRAKELFGADYANVQPHAGSQANSAVYLALLNPGDTVLGMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYEEVERLALEHKPRMIVAGFSAYSRVVDWQRFRDIADKVGAYLFVDMAHVAGLVAAGVYPNPVQIADVTTTTTHKTLRGPRSGLILAKANEEIEKKLQSAVFPGNQGGPLMHAIAAKAICFKEAMSDDFKAYQQQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAWLGAAHITVNKNSVPNDPRSPFVTSGIRIGTPAVTTRGFGEAEVRELAGWIADVIDSKGDEKVIADVKAKVEAVCAKFPVYAK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y347_METJA
Sequence: MGFDPVTFAKIKKISIDSNADGYIDYANQAGNADKLDGKDASDFLSIDSFKDLKEDNGYIKFPTGLIMQWGKVYVNNTTSYQEIPVNFTIEFPNKCLNVFASIYEGSGVDNDYIKCITRIANITTKGCVVCITDISGASGDVGFFWFAIGY
What are the official names of this protein?
Uncharacterized protein MJ0347.
Protein: DACB2_MYCTU
Sequence: MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGPAQTWIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAMANPVFAQITAEPSAMFPSDNGEQLIVNQDELLQRYPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFALNPQASVGSL
What is the function of this protein?
Probably cleaves the terminal D-Ala-D-Ala dipeptide of the peptidoglycan stem peptide (Probable).  Shows significant D,D-carboxypeptidase activity in vitro (PubMed:22906310).  Acts on the synthetic penta-peptide substrate Penta-DAP (L-Ala-gamma-D-Gln-DAP-D-Ala-D-Ala).  Shows also weak activity on Penta-Lys (L-Ala-gamma-Glu-L-Lys-D-Ala-D-Ala) (PubMed:22906310).  The catalytic domain binds weakly to peptidoglycan in vitro (PubMed:25551456).  Plays an important role in the maintenance of colony morphology and cell wall permeability and integrity (PubMed:25467937).
What are the official names of this protein?
D-alanyl-D-alanine carboxypeptidase DacB2, D,D-carboxypeptidase DacB2, DD-carboxypeptidase, DD-peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S11 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RIMO_ACIBS
Sequence: MKTPKVGFVSLGCPKALVDSERILTQLKTEGYQVASDYDGADLVVVNTCGFIESAVQESLDAIGEAMSENGRVIVTGCLGKDEDKIRQMHPNVLKVTGAAAYQDVMEAVHEYVPAPPKHNPFIDLVPEQGIRLTPKHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPVGSVLEEAAALKRAGVKEILVISQDTSAYGVDTKYKLDFWNGQPVKTKFFDMCEALGQLGIWVRLHYVYPYPHVDAVIDLMAQGKILPYLDIPFQHASPRVLKLMKRPAHSENTLEKIKLWREKCPDLVIRSTFVVGFPGETEEDFQILLDWLVEAQLDRVGCFTYSPVEGATANDLPDHVPEEIKQERYERFMQVQQQISAAKLQKRIGQTMTVLVDSLEDEYPVAVARSYADAPEIDGNVFVEDIDKSTIQPGDMLEVEITDADEYDLFAKLIKIKSV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRADD_MOUSE
Sequence: MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEIKAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEVTAELPTGDWMAGIPSHILSSSPSDQQINQLAQRLGPEWEPVVLSLGLSQTDIYRCKANHPHNVHSQVVEAFVRWRQRFGKQATFLSLHKGLQAVEADPSLLQHMLE
What is the function of this protein?
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis.  Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
What are the official names of this protein?
Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MYG_EQUQB
Sequence: MGLSDGEWQQVLNVWGKVEADIAGHGQEVLIRLFTGHPETLEKFDKFKHLKTEAEMKASEDLKKHGTVVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISDAIIHVLHSKHPGDFGADAQGAMTKALELFRNDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PHOT_BACSU
Sequence: MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQGFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMFWNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISALPLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLTGTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM
What is the function of this protein?
Exhibits the same spectroscopical features and blue-light induced photochemistry as plants phototropins, with the reversible formation of a blue-shifted photoproduct, assigned to an FMN-cysteine thiol adduct.  Although it is a positive regulator in the activation of the environmental signaling branch of the general stress transcription factor sigma-B, its precise role is undetermined.
What are the official names of this protein?
Blue-light photoreceptor, Photoactive flavo-yellow protein, Phototropin homolog.
Protein: TRUD_XANC8
Sequence: MSDSPVLPRAHGAAVLTAAMRSVAEDFQVDELPAFDASGEGEHLLLTVRKRGQNTAYVAKRLAQWAGIAEMGIGYAGLKDRHAVTTQRFSVHLPKRIAPDLSALDDDDMQVVEHTWHNRKLQRGALHGNRFVLTLREVVGDQAVIDARLHAIAARGIPNWFGEQRFGRDGGNVAAALAMFGHTRQPDGTLAPAPKRRLRNDQRSLLLSAARSALFNQVLTARVEQGNWDAPLDGEAWMLDGSRSVFGPEPWSEVLAERLARFDIHPSGPLWGAGELRCSADAAAIEQAALSDPQSLALRTGLEAAGLKQERRALRLRPQGLAHAWLDAQTLQLTFALPPGCYATAVLWELGEVVDAARVAPQSRSEG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: TSAD_HAEDU
Sequence: MRILGIETSCDETGVAIYDEQRGLIANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQAALKEANLTASEIDGIAYTAGPGLVGALLVGATIARALAYAWNVPALAVHHMEGHLMAPMLEENPPEFPFIALLISGGHTQLIKVAGVGEYEILGESIDDAAGEAFDKTGKLLGLDYPAGVALSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINAQLDENGQLNEQTRCDIAHAFQQAVVDTIIIKCKRALQQTGYSRLVMAGGVSANKQLRAELATMMQALKGQVYYPRPQFCTDNGAMIAYTGFIRLKKGEKTDLSVSVKPRWPMTTLLKLSAHHKV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTU3C_STAAT
Sequence: MFKKLFGQLQRIGKALMLPVAILPAAGILLAFGNAMHNEQLVEIAPWLKNDIIVMISSVMEAAGQVVFDNLPLLFAVGTALGLAGGDGVAALAALVGYLIMNATMGKVLHITIDDIFSYAKGAKELSQAAKEPAHALVLGIPTLQTGVFGGIIMGALAAWCYNKFYNITLPPFLGFFAGKRFVPIVTSVVAIATGVLLSFAWPPIQDGLNSLSNFLLNKNLTLTTFIFGIIERSLIPFGLHHIFYSPFWFEFGSYTNHAGELVRGDQRIWMAQLKDGVPFTAGAFTTGKYPFMMFGLPAAAFAIYKNARPERKKVVGGLMLSAGLTAFLTGITEPLEFSFLFVAPVLYGIHVLLAGTSFLVMHLLGVKIGMTFSGGFIDYILYGLLNWDRSHALLVIPVGIVYAIVYYFLFDFAIRKFKLKTPGREDEETEIRNSSVAKLPFDVLDAMGGKENIKHLDACITRLRVEVVDKSKVDVAGIKALGASGVLEVGNNMQAIFGPKSDQIKHDMAKIMSGEITKPSETTVTEEMSDEPVHVEALGTTDIYAPGIGQIIPLSEVPDQVFAGKMMGDGVGFIPEKGEIVAPFDGTVKTIFPTKHAIGLESESGVEVLIHIGIDTVKLNGEGFESLINVDEKVTQGQPLMKVNLAYLKAHAPSIVTPMIITNLENKELVIEDVQDADPGKLIMTVK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in alpha- and beta-glucoside transport (By similarity).
What are the official names of this protein?
PTS system glucoside-specific EIICBA component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PROFT_OLEEU
Sequence: MLWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGVMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-2, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MRAY_STRAW
Sequence: MMKQILFSGVIGLFLTLVGTPLLIKLLARKGYGQYIRDDGPREHHSKRGTPTMGGIAFILATIIAYFMSKVITGYTPTFSGLLVLGLMAGMGLVGFLDDYIKIVKRRSLGLRAKAKMAGQLIVGIAFAVLALQFADNHGNTPASTRLSFVEDFGWTIGPVLFVIWALFMILAMSNGVNLTDGLDGLATGAATMVFGAYTFIGVWQFQESCANAQTLTNPAACYEVRDPLDLAVVASALMGACFGFLWWNTSPAKIFMGDTGSLALGGALAGLAICSRTELLVALLGGLFVLITMSVVIQVGSFRLTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGMCVIVGLGLFYAGWAAKK
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA_SHIF8
Sequence: MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: Y273_HALLT
Sequence: MSRTALIENITAMLEDADFLVSDRCAVRPKSFDVAARRDEDLVLLKILGNVDALDAETGAEMRRLGEYLQATPMVIGIRTRDEELKPGVVYFRHGVPVINPDTGYDLFVEGMPPLIYAAPGGLYVSLDGDLLADEREERGWSLGRLATELGVSRRTVSKYEDGMNASIEVAIQLEDLFNEPFSSPVDVLDGAGEVRDADPTPSAPETDPDDEHVLHVLTNAGFTVHPTARAPFKAVSEDEGSSPARVLTGHSTFTPAAEKRARIMSSIGEVARTRSVYFTEENEDRESVDGTALVSCEELADISDPEGIRELIRDRAKAPSEA
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein Hlac_0273.
Protein: GYRB_BACCE
Sequence: HAGGKFDGGGYKVSGGLHGVGASVVNALSTELEVFVHREGKIHYQKYERGIPVADLKVIGDTDQTGTITRFKPDPEIFQETTVYDFDTLATRMRELAFLNRNIKLTIEDKRERKQKKEFHYEGGIKSYVEHLNRSKQPIHEEPVYVEGSKDGIQVEVSLQYNEGYTNNIYSFTNNIHTYEGGTHEVGFKTALTRVINDYGRKNSILKDADSNLTGEDVREGLTAIVSIKHPNPQFEGQTKTKLGNSEARTITESVFSEAFEKFLLENPNVARKIVEKGTMAARARVAAKKARELTRRKSALEVSSLPGKLADCSSKDPAISEIYIVEGDSAGGSAKQGRDRHFQAILPLKGKIINVEKARLDKILSNDEVRTIITAIGTNIGGDFDIEKARYHKVIIMTDADVD
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSUN2_CHICK
Sequence: MGRRARDRRRQLQPQQRRERSGGGGGGGDDQAGWAGGYPEIVKENELFERYYREQRIVPDGEWDAFMAALREPLPATLRITGYKSHAREILHCLKEKYFRELQHLEVDGQKVEMPQALSWYPEELAWHTNLSRKILRKSPQLERFHQFLVSETECGNISRQEAVSMIPPLLLNVNPDHKILDMCAAPGSKTAQLIEMLHADMNVPFPKGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPNLQVDVDGRKETLFYDRILCDVPCSGDGTMRKNIDVWKKWTTQNSLQLHGLQLRIATRGVEQLAEGGRMVYSTCSLNPIENEAVIASLLEKSQGALELADVSSELPGLKRMPGITKWKVMLKDGQWFEEWKDVPSNRQTQIRPTMFPIKEEEKLKAMNLERCIRILPHHQNTGGFFVAVLIKKSPMPWNKRQPKVHQKLPGKTEDTEVTATNAGDGSEDATEKPTLAEDEEPKKVQELQNSDTEQSKKGVCGPPPSKKMKLFGFKEDPFVFLPEDDPLFLPIQKFYALDPSFPKMNLLTRTQEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWSRNSDGEQFGCAFRLAQEGIYTLYPFIHARIVNVCIEDVKILLTQENPFLSKFSSETQRKVKDMAMGSIVLKYEPDPEKPDDLQCPIVLCGWQGKTSLRAFVPKNERLHYLRMMGVEVFKAKRKEGESEGKTEEEVQCRPAQTEEGMDVEDKERDAVTKMEAEIDEESPRSPVESSAMEIENKSEDSDQCSKNTNSHINQESKDMNTNNVKD
What is the function of this protein?
RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs).  Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay.  Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors.  tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs).  Also mediates C(5)-methylation of mitochondrial tRNAs.  Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay.  Cytosine C(5)-methylation of mRNAs also regulates mRNA export.  Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs.  Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
What are the official names of this protein?
RNA cytosine-C(5)-methyltransferase NSUN2, NOL1/NOP2/Sun domain family member 2, mRNA cytosine C(5)-methyltransferase, tRNA cytosine C(5)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Secreted, extracellular exosome.
Protein: TRM71_DROME
Sequence: MGKTSKDKRDIYYRQAKDEGWRARSAFKLLHVDEAYGILNGVQRAVDLCAAPGSWSQVLSRKLYDTCETDDEKSAVKIIAVDLQAMAPIRGILQLQGDITKQSTAEAIIGHFGGNEKAQLVVCDGAPDVTGVHEMDEYMQHQLLVAALSIATCVLETGGTFVAKIFKGNATSLLSSQMQIFFKKFDIYKPPSSRPSSIEAFVVCSDFCLPEGYIPQVINPARDDIRLLAQKTGSEVNRRLVPFIACGDLNGLSDPEEGKTSSSDESKSNLEYVYDAVMDDASYPLEFKEILKQVYDEQRHII
What is the function of this protein?
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
What are the official names of this protein?
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 1, 2'-O-ribose RNA methyltransferase TRM7 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMTA_ECO55
Sequence: MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLDHVARNHPAPQAPRYIYKLEQALDAM
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.  Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
What are the official names of this protein?
Endo-type membrane-bound lytic murein transglycosylase A, Peptidoglycan lytic endotransglycosylase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y017_SIFVH
Sequence: MINMGGKTLIINWENPLNRDAYTEIGKLMVLVLPYVVNIEIVDTEGCIMEIDDTIEDEIKELSRFLKYVEVSFAEE
What are the official names of this protein?
Uncharacterized protein 17.