PharMolix/UniProtQA huggingface dataset:
Protein: IFM2_HUMAN
Sequence: MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGVPHNPAPPMSTVIHIRSETSVPDHVVWSLFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGIFMTILLIIIPVLVVQAQR
What is the function of this protein?
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:33563656, PubMed:26354436).  Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:33563656, PubMed:26354436, PubMed:33270927, PubMed:33239446).  Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656).  Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.  In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436).  IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).
What are the official names of this protein?
Interferon-induced transmembrane protein 2, Dispanin subfamily A member 2c, DSPA2c, Interferon-inducible protein 1-8D.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein.
Protein: RECF_GEOSL
Sequence: MHLNAIAISAFRNIDHVEISFDRRFNVLHGANGQGKTSVLEAIYLLGTMKSFRMAKAHDLIAWNAPHSLVRGDIDKAGVRREIALYLGREGRKARIDRKPVTKLADFFGAVNAVVFSPEEIGMARGGPELRRRYLDRAIFNGDLGYLLLHHEYHRLLKQRNALLRRGERDGLEVWTIQLAEAGARLMVKRRAYLSQIEPLVRQFYRDIAGAGQEVGLAYRCHGLASAEGERDCAAALRELMAAHEAEELRRGATGVGPHRDDVDFILNGRVIRHHGSQGEQRSFVLAVKMAEIEYLERLNGAPPVLLLDDISSELDPERNANLMTFLRGKRMQVFITTTDVSTLRLEGIDTHASFRVSRGTVTPV
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_XANOP
Sequence: MRYALGVEYDGSEFQGWQQLGEHGGPSVQASLQAALSSVADAPVQVVCAGRTDAGVHGECQVVHFDSDAHREPRGWMLGTTARLPPSIAVRWCVPAAADFHARFSARARRYRYRLLNRQIRPALYRQTLSWERRPLDADAMHVAAQALLGENDFSAFRSVQCQALHARRNLQAIHVQRIGEVVEVQVQANAFLHHMVRNIVGSLILVGTGEQPADWIATLLAGRDRTVAGPTAPPQGLVFIGPLYPAEWHLPAEVTQ
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: NIPSN_DROME
Sequence: MLKLRNLLAVGKSNNNAVRSLSTTPSRNDSESWFSKLLVRKIEPTKESHSRMLSDKEIIYALHTHNVRPDSMGSYLNNYKTTVALINEKKANLSCELVASWTVQVGDMDQCLHLWKYTGGFEKIDQAKEDLWNDPEYLSLMQERSKFLRSRHLQYLLAFSYWPQIASRTGKNIYEMRSYRLTPGTMIEWGNNWARAINYRKHNNEAFAGFFSQIGRLYNVHHIWCYKSLQDRKETREAAWRSPGWDECVAYTVPLIREMHCRVLAPTEFSPSQ
What are the official names of this protein?
Protein NipSnap.
What is the protein family that this protein belongs to?
Belongs to the NipSnap family.
Protein: FOLD_SHELP
Sequence: MTAQIIDGKAIAQSIRKQLSAKVTARKEAGKRVPGLAVILVGADPASQVYVGSKRRACEEVGFLSQSFDLPTETSEADLLALIDKCNEDPSIDGILVQLPLPDHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTRDLEDKVRRADLLIVAVGKPNFIPGEWIKPGAIVIDVGINRLESGQLVGDVQYDVAAEHASHITPVPGGVGPMTIASLLENTLYAAENYHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FOLB_STRCO
Sequence: MDRVALRGLKARGHHGVFPKEREDGQTFLVDIVLGLDTRPAAADDDLAKTVHYGIVAEEVVAVVEGEPVNLVETLAERIAQVCLKHEGVEEVEVCVHKPDAPITVPFDDVTVTIIRSRV
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: AROC_HALMA
Sequence: MNGNEFGRLFRMTTYGESHGEAMGCTVSGVPAGVELSEEEIQKDLDRRKPGQSMITTSRGEPDKVTINSGIQDGYTTGTPIGMVIQNKDARSGKYEPFITAPRPSHGDYTYSAKFGTRNWGGGGRSSARETVNWVAAGGVAKQVLEQSDYDVQIKAHVCQIGDVEAGPVTFEDMLEHSEENEVRCADPEAAEEMRDVADQHQKEGDSIGGAIYFECRGVPSGLGAPRFDSFPSRLGQAMYSIPAVNDFEYGIGREARTTKGSEYTENWEFDEDGHPTPVGNDHGGIQGGITTGQPIYGEVSWHAPVSIPKTQETVDWETGEGKEITVTGRHDPVLPPRAVPVVEAMLACTVLDFMLLGGRINPDRLDGRPGEYDTDYHPSSPQNDPEDADTHAKTIDDD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: AGUA2_LISMF
Sequence: MGQLKGLPVEDGFRMPGEYEPHIGCFMIWPERPDNWRLGGKPAQQNYKEVAVAISNFEPVTMFVSPNQYKNARKELPDTIRVIEMSNDDAWIRDYGPSFLVNDKGEMRGVDWGFNAWGGLLDGLYFPWDKDNQIAKKVCDLERLDYYSQKDFILEGCSIHVDGEGTLVTTEECLLSEGRNPNLTKIEIEQTLKKYFHVQKVIWLKHGFYLDETNGHVDNIFNFVAPGEVVLSWTDNKSDPQYEISRECYDILANQTDAKGRTFMIHKLHCPDPVLITQTESEGVEAINGTFPRQAGDRLAASYVNYYTANGAIIFPLFDDPKDKDAQELLEQLYPDRKIVGIKAREILLGGGNIHCITQHLPDKSTIRE
What are the official names of this protein?
Putative agmatine deiminase 2, Agmatine iminohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the agmatine deiminase family.
Protein: MPD1_YEAST
Sequence: MLFLNIIKLLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEVYSGARTLAPIVDFSLSRIRSYVKKFVRIDTLGSLLRKSPKLSVVLFSKQDKISPVYKSIALDWLGKFDFYSISNKKLKQLTDMNPTYEKTPEIFKYLQKVIPEQRQSDKSKLVVFDADKDKFWEYEGNSINKNDISKFLRDTFSITPNEGPFSRRSEYIAYLKTGKKPIKKNHSSSGNKHDEL
What is the function of this protein?
Participates in the folding of proteins containing disulfide bonds.
What are the official names of this protein?
Protein disulfide-isomerase MPD1.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: NRDR_STRP3
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: UBIG_SODGM
Sequence: MIPEVSNEASQPAAHRQENVDPNEIAKFDAVAARWWDLEGEFKPLHHINPLRLDYILERSGGLFGKNVLDVGCGGGILAESMAREGAKVTGLDMGAEPLAVARLHALESGVMLAYHQQTVEEHAEAHPGAYDVVTCMEMLEHVPDPASIVRACARLVKPGGEVFFSTLNRNPKAWLMAIVGAEYVLRMVPRGTHDITKFIKPAELLGWVDDTPLREQHIIGLHYNPLRDRFYLGGNVDVNYMLHTRRQA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: SEM3B_MOUSE
Sequence: MGRAEAAAMIPGLALLWVAGLGDTAPNLPRLRLSFQELQARHGVRTFRLERTCCYEALLVDEERGRLFVGAENHVASLSLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHTYNHTHLLACGTGAFHPTCALWRWATAGGTHASTGPEKLEDGKGKTPYDPRHRAASVLVGEELYSGVTADLMGRDFTIFRSLGQNPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRESAVEAAPAMGRMSVSRVGQICRNDLGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDRQTPLLYAVFSTSSGVFQGSAVCVYSMNDVRRAFLGPFAHKEGPTHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNPVLPMGGRPLFLQVGAGYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPNSEGLLLEELQVFEDSAAITSMQISSKRQQLYIASRSAVAQIALHRCTALGRACAECCLARDPYCAWDGSACTRFQPTAKRRFRRQDIRNGDPSTLCSGDSSHSVLLEKKVLGVESGSAFLECEPRSLQAHVQWTFQGAGEAAHTQVLAEERVERTARGLLLRGLRRQDSGVYLCVAVEQGFSQPLRRLVLHVLSAAQAERLARAEEAAAPAPPGPKLWYRDFLQLVEPGGGGGANSLRMCRPQPGHHSVAADSRRKGRNRRMHVSELRAERGPRSAAHW
What is the function of this protein?
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
What are the official names of this protein?
Semaphorin-3B, Semaphorin-A, Sema A.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YFCN_SALDC
Sequence: MKKKTSLSEEDQALFRQLMVGTRKIKQDTIVHRPLRKKITEVPTRRLIQEQADASHYFSDEFQPLLNTEGPVKYVREDVSHFELKKMRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHIFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWQPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: RL31_ECO57
Sequence: MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKCHPFFTGKQRDVATGGRVDRFNKRFNIPGSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: HEMH_NOSS1
Sequence: MGRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEALKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNLVILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIPSWYKEPGYLQAMAELIRQEIEQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVGPVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRRVPAPNTHPVFIRALADLVIDALNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNGRIAMLGFIALIIELVTGQGLLHMIGLLQ
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_MYCMM
Sequence: MTERAGLRLHDTAAGAVRDFVPLREGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLMARGFDVAFIRNVTDIDDKILNKAAAAERPWWEWAATYERAFTAAYDALDVLPPSAEPRATGHVTQMVELIERLIERGHAYAGGGDVYFDVLSYPDYGQLSGHKVDDVHQGEGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHLECSAMARTYLGAQFDIHCGGMDLIFPHHENEIAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPTMLQRVRPAELRYYLGSAHYRSMLEFSDIALQDAVNAYVGVEEFLHRVRSRAGVVVVGDWTPRFAAALDDDLSVPIALAEIHHTRAEGNRALDAGDHDAALQSASSIRAMMGILGCDPLDERWESRDETSAALAAVDVLVQAELENRQKAREERNWALADEIRNRLKNAGIEVTDTADGPQWLLGGDGK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOA2_PANPA
Sequence: MKLLAATVLLLTICSLEGALVRRQAKEPCVDNLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFMELGTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1210_ACTP7
Sequence: MAGHSKWANIKHRKAAQDAQRGKIFTKLIRELVTAAKIGGGDVSANPRLRSAVDKALSNNMTRDTINRAIERGVGGGDDTNMETKIYEGYGPGGTAVMVECLSDNANRTISQVRPSFTKCGGNLGTEGSVGYLFSKKGLILIASGDEDALTEAAIEAGADDIQPQEDGSFEIYTAWEDLGSVRDGIEAAGFKIQEAEVTMIPSTTVELDAETAPKLLDLINRLEDCDDVQNVYHNGEISDEVAALL
What are the official names of this protein?
Probable transcriptional regulatory protein APP7_1210.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPB_CHICK
Sequence: MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKLKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLQEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPSHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVTEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRPLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEVTVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVSLVQEKKKQNSFIAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMSSKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPASCTDAEFRQMWAEFEWENKVTVNTNIIDLNEYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKPIHLGPEAPVTGHIRIRAKSQGMALSLGDKINLSQKKTSL
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit beta, Beta-coat protein, Beta-COP.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: Y1001_RHIME
Sequence: MWFLVKATFWFSLVLVLLPFLDPSSSEKLEHGPKMEIGGTFSAANEAIQYISAICVEKPDVCEKGAETFVALGHRAREGARIAYEFLNTQFAEGDAAAPDVKVMTGTVTPAESVPSAEATEKAEPAFKRMPVPEHRLDPGPASGK
What are the official names of this protein?
Uncharacterized protein R01001.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PGK_SINMW
Sequence: MTFKTLDDLTDIAGKRVLVRVDLNVPVKDGQVTDTTRIERVAPTIRELSEKGAKVVLLAHFGRPKGEPVADMSLKTIASAVEEILDQRVYFAPDCIGDKAANAIADLNDGEVLLLENTRFHKGEEKNDPAFVTALAANGDIYVNDAFSAAHRAHASTEGLAQHLPAYAGRTMQAELEALEKGLGNPQRPVVAIVGGAKVSTKIDLLQNLVKKVDALVIGGGMANTFLAAQGVDVGKSLCEHDLAETAKAILAAASEAGCAIVLPVDGVVAREFKAGADNEVVDVKAIPADAMMLDVGPKSIDAINEWISRAETLVWNGPLGAFEITPFDKATVAAAKHAAARTRSGSLVSVAGGGDTVAALNHAEVADDFTYVSTAGGAFLEWMEGKPLPGVDILKQQR
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC12_YEAST
Sequence: MLKLRQLQKKKQKENENSSSIQPNLSAARIRLKRDLDSLDLPPTVTLNVITSPDSADRSQSPKLEVIVRPDEGYYNYGSINFNLDFNEVYPIEPPKVVCLKKIFHPNIDLKGNVCLNILREDWSPALDLQSIITGLLFLFLEPNPNDPLNKDAAKLLCEGEKEFAEAVRLTMSGGSIEHVKYDNIVSP
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.  The major substrate is CDC53/Cullin.
What are the official names of this protein?
NEDD8-conjugating enzyme UBC12, RUB1-conjugating enzyme, Ubiquitin carrier protein 12.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Protein: DAU1_DAUCA
Sequence: MGAQSHSLEITSSVSAEKIFSGIVLDVDTVIPKAAPGAYKSVEVKGDGGAGTVRIITLPEGSPITSMTVRTDAVNKEALTYDSTVIDGDILLGFIESIETHLVVVPTADGGSITKTTAIFHTKGDAVVPEENIKFADAQNTALFKAIEAYLIAN
What are the official names of this protein?
Major allergen Dau c 1, CR16, Pathogenesis-related protein Gea20.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: NQRE_VIBVY
Sequence: MEHYISLLIKSIFIENMALSFFLGMCTFLAVSKKVKTSFGLGVAVVVVLTIAVPVNNLVYNLVLKENALVEGVDLSFLNFITFIGVIAALVQILEMILDRFFPPLYNALGIFLPLITVNCAIFGGVSFMVQRDYNFAESVVYGFGAGVGWMLAIVALAGIREKMKYSDVPPGLRGLGITFITVGLMALGFMSFSGVQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TFB1M_PONAB
Sequence: MAASGKLSTWRLPPLPTIREIIKLLRVQAAKQLSQNFLLDLRLTDKIVRKAGNLTNAYVYEVGPGPGGITRSILNADVAELLVVEKDTRFVPGLQMLSDAAPGKLRIVHGDVLTFKVEKAFSESLKRPWEDDPPDVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQYLCNVRHIFTIPGRAFVPKPEVDVGVVHFTPLIQPKIEQPFKLVEKVVQNVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADVDPTLRPCQPSISHFKSLCDVYRKMCDEDPQLFAYNFREELKQRKSKNEEKEEDDAEN
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.  Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM.  Stimulates transcription independently of the methyltransferase activity (By similarity).
What are the official names of this protein?
Dimethyladenosine transferase 1, mitochondrial, Mitochondrial 12S rRNA dimethylase 1, Mitochondrial transcription factor B1, mtTFB1, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ILVC_PARL1
Sequence: MRVYYDRDADVNLIKGKKVAIIGYGSQGHAHALNLRDSGVKEVAVALRAGSATAKKAEGEGLKVMTVADAAKWADVLMMLTPDELQADIYYADLHENMKPGSALLFAHGLNIHFNLIEPRKDIDVLMVAPKGPGHTVRSEYKRGGGVPSLIAVHQDATGNAHDVGLSYASANGGGRAGIIETTFREECETDLFGEQVVLCGGLVELIRAGFETLTEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLHDIQSGKFTRDWMLENKVNQTSFKATRAAAAAHPIEEVGARLREMMPWISANKLVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: THIM_DESPS
Sequence: MSNISLTAAENLQQIRENKPLIHNITNFVVMNYTANVLLATGASPVMAHAQNEVEEMVAFAGSLVLNIGTLSESWVSSMLMASQRANTLKTPIILDPVGSGATAFRTASAKRIIAEAKVSVIRGNASEILSLGSEQSNTRGVDTSQSVSDAAQTASLLARELDTILAITGPTDLVTDGRRVFNVDNGHPLMPYVTGTGCSATAVVGAFAAVDRDYLRAATTALAFFGLAGEMAGKAATGPGSFMIHLLDALYNMSPEQLEKGCRIKESSATRS
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: NADA_BURCM
Sequence: MQSTIKPVEYDRPVAAGTVCGVGQAWAKVPDAPSAEERAALKARIKALLAREKAVLVAHYYVDAELQELADETGGCVADSLEMARFGRDHDAQTLVVAGVRFMGETAKILSPGKRVLMPDLDATCSLDLGCPADEFSAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLEIVADLHARGEKIIWAPDRHLGSYIQKKTGADMLLWQGSCLVHDEFKGIELDLLRAEYPDAKVLVHPESPENVVAQADVVGSTTQLIDAAVKLDATHFIVATDLGILHKMQLAAPGKTFIAAPTAGNSATCKSCAHCPWMAMNGLANLADVLERGHNEIFVDPAIGVRARLPIDRMLDFAAAHKKRVQASGDLQRDQQLFANVGAA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFP27_MOUSE
Sequence: MDVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSVEELQQIGDQKKTYQQIGHKSASDMVFITKTLGAESCHDYSGVRKVIHVNSYIVLPPKRPRHWDPPEDEPKHSSDLQTHDESNGLKRTKRITEYGKISSCINTEHILTGEKLPDHNQCGKVLGYKQIPCQYQKIHTGEKSYECAEFGKIFTQKSQLRVHVTSPTGEKLYVCVECGKACSQTSEFLTHQKTHTREKPYKCGDCGKSFFQVSSLFRHRRIHTGEKLYDCSHCGKGFSYNSDLRIHQKIHTGEKRHGCVDCGKAFTQKSTLRMHQKIHTGERAYVCIECGQAFIQKTHLVAHRRIHTGEKPYACDGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKPFSSAPNLLPRKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKSALTVHRRIHTGEKSYVCVKCGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIHTGEKPYVCSNCGKAFANRSNLITHQKTHTGEKAYVCARCGKAFTQRSDLVTHQRIHTGEKPYGCSTCGKAFTQKSHLSIHEKIHTGERQYGCRDCGKAFNQKSILIVHQKIHTGEKPHVCAECGRAFIRKSNFITHQRIHTGEKPYGCTDCGKSFTSKSQLLVHRPIHTGEKPYVCAECGKAFSGRSNLSKHQKTHTGEKPYACSECGKSFRQKSELITHHRIHTGEKPYDCGDCGKSFTKKSQLQVHQRIHTGEKPYRCAECGKAFTDRSNLNKHQTTHTGEKPYKCVVCGKGFVQKSVLSIHENVHTSAV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 27, Zfp-27, Protein mKR4.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUFE_ECOBW
Sequence: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEDRSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.