PharMolix/UniProtQA huggingface dataset:
Protein: IF4A3_DANRE
Sequence: MATAVVPVRKRILKEEDMTKIEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFCVSVLQCLDIQVRETQALILAPTRELAGQIQKVLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVCLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVSQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase.  Involved in pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity).  Involved in craniofacial development (PubMed:24360810).
What are the official names of this protein?
Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic translation initiation factor 4A isoform 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: Y355_STRP6
Sequence: MFQKQERIGLVVYLYYNRDARKLSKFGDLYYHSKRSRYLIIYINKNDLDTKLEEMRRLKCVKDIRPSAFDDIDRQFVGNLHRDETNNHQKG
What are the official names of this protein?
UPF0298 protein M6_Spy0355.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NARF_DROER
Sequence: MSGLSRALQLTDIDDFITPSQMCIKPVKIDKAKSKTGAKIMIKDDSCFEESESGKKKLNKVEITLQDCLACSGCITSAEGVLITQQSQEELLRVLQENLTKKATEDWGNVRTIVFTIATQPLLSLAHRYQIGVEDSARHLAGYFRSLGADYVLSTKVADDIALLECRQEFVERYRENENLTMLSSSCPGWVCYAEKTHGNFILPYISTTRSPQQIMGVLVKHVFAEKLNVPASQIYHVTVMPCYDKKLEASREDFFSTANNSRDVDCVITSVEVEQLLSESQRTLAQYDPVDLDWPWSNVPPDFMVWAHEKTLSGGYAEHIFKFAAKELFNEVPRSELEFKQLKNRDFREIILKKNGNTVLKFAIANGFRNIQNLVHKLKRGKVSNYHFVEVMACPSGCINGGAQIRPTTGQHVRELTRKLEELYHNLPQSDPENSLTKLIYTDFLDGFQTEKSYELLHTRYHDVVSELSKSLNINW
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins (By similarity).
What are the official names of this protein?
Probable cytosolic Fe-S cluster assembly factor GG21400.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: F1142_MOUSE
Sequence: MSDKDPPESPVVTGVASTLKDENCEPVEKPEDKSQPVVSTRKRPETKPSSDLEASALPAQVSLAVAKETASKDVPQTGWGYWGSWGKSLLSSASATVATVGQGISNVIEKAETSLGIPSPTEISAEVKQAAGEKNAGENGSLLVAAPFGMLSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRTSTLSQVLREAKDKEEQRPSNEVTMETDKKTHYGLLFDEFQGLSHLEALEMLSRESEIKVKSILSSLSGEELQTTRLELEQLKEVFSLAEFCEEEEEERQGDDNFTKEITDLFAQLHVSSRPEKLARARNTAYKWIRTSLARPVAEKEEGEKESEAGNTEEAQKHSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGQKQEVTALERSQTLSQMTVMLCKDLASLSKEFTTCLTTAGVREKADVLNPVITAVFLEASNSASYIQDAFQLLLPVLQISLIESKTESSTCEPQSRDL
What are the official names of this protein?
Protein FAM114A2.
What is the protein family that this protein belongs to?
Belongs to the FAM114 family.
Protein: GCH1_CAEEL
Sequence: MSRIENESGFLSSDAASVGSEDDKVEMKKRNGTIPKEDHLKSMCNAYQSIIQHVGEDINRQGLLKTPERAAKAMMAFTKGYDDQLDELLNEAVFDEDHDEMVIVKDIEMFSLCEHHLVPFMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQERLTKQIATAMVQAVQPSGVAVVIEASHMCMVMRGVQKINASTTTSCMLGVFRDDPKTREEFLNLINKR
What is the function of this protein?
Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: YCF46_NEOYE
Sequence: MNFTQDLRLLLKSRYPIIVINTREEDRLEYIIKHSLNCSNSQQVYSWDFVDGYTNNPSDNGYAKRNPLLALEFIENLNNESLNLFLLKDFDSFLNEIVLIRKLRNLAKIIKTQSKHIIIISCKINIPFALNDIITVIDLPLPSLLEIKKEIIRLSKALNLNLNSELVNNITKSCQGLSIDRIRKVITKIIAQYNQIDSRSLPIIIEEKRQIINQTHLLEFYPYSKVNRDIGGLDVLKQWLQKRSRSFSKQSLNYGIPSPKGLLLVGIQGTGKSLTAKAIASDWMLPLLRLDMGKLFGGLVGESESKMREMINISEGLSPCILWIDEIDKAFSGLHSQGDSGTSARVFGTFITWLSEKKAPVFVVATANKIQSLPSEMLRKGRFDEIFFLDLPNRQERESIFKIHLSKVRPRSWQKYDIHELSLLCNKFSGAEIEQAIIESMHTAFSEEREFSTEDIKIAIKQFVPLAFTDKEQVESLQAWAGDGRARNASLT
What are the official names of this protein?
Uncharacterized AAA domain-containing protein ycf46.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Highly divergent.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ARGC_STAAR
Sequence: MIKVGIVGGSGYGAIELIRLLQTHPHVTIAHIYSHSKVDEPLKLTFPHLQHIMQHFEALTVDNNDCDVIFFATPAPVSKTCIPPLVEKGIHVIDLSGAFRIKNREIYEAYYKETAAAQDDLNHAIYSISEWQSLDNNGTKLISNPGCFPTATLLALHPLISEKIVDLSSIIIDAKTGVSGAGRSLSQRVHFSEMNENLSAYAIGNHKHKPEIEQYLSIIAGQDVSVIFTPHLVPMARGILSTIYVKLSSEYTTESLHKLMTSYYANQPFVRIRDIGTFPTTKEVLGSNYCDIGIYVDETTQTAILVSVIDNLVKGASGQAIQNLNILYDFEVTTGLKQSPVYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_LEUCK
Sequence: MSEKTIAIKAQKVEEIADQFKNAASAVVVDARGLTVAQSTELRHQLREEGIVLEVIKNKILTRAAEKAGFAELNDIFAGPSAVAFSNDDAVAPSRILKKFADANEKLEIKGGVVDGTIANIEDINKYASLPSREGLLGQLMAEFQFSIRSFAYAVKAVQDKLEEGGEAAEEALAAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: VIF_HV1JR
Sequence: MENRWQVMIVWQVDRMRIRTWNSLVKHHMYISGKAKGWIYKHHYESTNPRVSSEVQIPLGDARLVITTYWGLHTGERDWHLGQGVSMEWRTRRYSTQVDPDLADQLIHLYYFDCFSESAIRNAILGHIVSPRCEYQAGHSKVGSLQYLALTALIKPKKIKPPLPSVKKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: ENO_PARMW
Sequence: MIDSLDLVIDTIVAREVLDSRGNPTVEAEVLLEGGAMGRAIVPSGASTGAHEAHELRDGGDRYMGKGVSQAVTHIEERIAPTLCGLSALDQAAVDAAMLELDGSDNKSSLGANAILAVSMATARAAANGLGLPLYRYLGGPMANLLPVPLMNVINGGAHAANSLDFQEFMLVPHGAPSFREALRMGTEVFHTLKGLLKAKGMSTSVGDEGGFAPDLGNVEAGEILVEAITKAGYKPGEQISLALDVASTEFFENGRYAFDGGNYDSAEMVGQLEQLVEKFPIVSIEDGLAEDDWEGWKLLTERLGGKVQLVGDDLFVTNTKRLQQGIDNSTANSILIKVNQIGSLTETLQAIDLAGRSGYTSVISHRSGETEDTTIADLSVATRAGQIKTGSLSRSERVAKYNQLLRIEDELGSQAVYAGAVGQGPRGNA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: KA104_CENTE
Sequence: AVCVYRTCDKDCKRRGYRSGKCINNACKCYPYA
What is the function of this protein?
Blocks human voltage-gated potassium channel Kv1. 2/KCNA2 (IC(50)=3. 6 nM) and Kv1. 3/KCNA3 (IC(50)=72 nM).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 10.4, Toxin II.10.4.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 10 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL36_RICAH
Sequence: MKVVSSLKSLKKRDKDCQIVKRRGKIFVINKKNKRFKAKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RS12_RHOCS
Sequence: MPTINQLIRKPRAPLVARDKVPALQECPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGYEVISYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGVLDTQGVKDRRQRRSLYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: MYG_PHOVI
Sequence: MGLSDGEWHLVLNVWGKVETDLAGHGQEVLIRLFKSHPETLEKFDKFKHLKSEDDMRRSEDLRKHGNTVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSKHPAEFGADAQAAMKKALELFRNDIAAKYKELGFHG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RBFA_SHEPW
Sequence: MAKEFSRTRRIAQQLQQELAVVLQRDMKDPRIGFVTVNDVDVSRDLSYAKVFVTFFEEDEKLVQEKVEALDAAAGYIRSLVAGRMKLRVMPELRFIYDSSLVEGMRMSNLVSRVISDDEAKQQEHGTVENAKQDGDKAEDDK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_GEOTN
Sequence: MAKNVRVRYAPSPTGHLHIGGARTALFNYLFARHYGGKMVVRIEDTDIERNVEGGEESQLENLKWLGIDYDESIDKDGGYGPYRQTERLDIYRKYVNELLEQGHAYKCFCTPEELEREREEQRAAGIAAPQYSGKCRHLTPEQVAELEAQGKPYTIRLKVPEGKTYEVDDLVRGKVTFESKDIGDWVIVKANGIPTYNFAVVIDDHLMEISHVFRGEEHLSNTPKQLMVYEYFGWEPPQFAHMTLIVNEQRKKLSKRDESIIQFVSQYKELGYLPEAMFNFFALLGWSPEGEEEIFTKDELIRIFDVARLSKSPSMFDTKKLTWMNNQYIKKLDLDRLVELALPHLVKAGRLPADMSDEQRQWARDLIALYQEQMSYGAEIVSLSELFFKEEVEYEDEARQVLAEEQVPDVLSAFLANVRELEPFTADEIKAAIKAVQKSTGQKGKKLFMPIRAAVTGQTHGPELPFAIQLLGKQKVIERLERALHEKF
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK2_CATRO
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLAQDPESKVACETCTKTNMVMVFGEITTKAQVDYEKIVRDTCRAIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNDNGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVVPEKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDKEILKIVKENFDFRPGMIAINLDLKRGGNSRFLKTAAYGHFGREDPDFTWEVVKPLKFEKVEA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_PSEE4
Sequence: MNTVKTVRELRAAVARARGEGKRIAFVPTMGNLHSGHAALVTKAAQRADFVVASIFVNPLQFGAGEDLDKYPRTLAADQEKLLQAGCHLLFAPTVEEMYPDGMAVQTRVSVPQLSEGLCGASRPGHFEGVATVVSKLFNMVQPDLAVFGEKDFQQLAVIRAMVRDLNMPIQIIGEPTVRAEDGLALSSRNGYLSPEQRAAAPALYRTLNGMAEAIRRGQRDFSALVADGQAQLDAAGFRKDYLEVRHALTLRPAQVDDRDLVVIAAAYMGSTRLIDNLYLHLEEQTA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHS16_CAEEL
Sequence: MLELIYILPLLCFVYFLFRRFVLENFYVESSGKYVMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTLQLDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNTLGAVRMCHAFVPLIKKSRGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEMRPFGVSVHILEPGCFKTELLNNDAQRMRIQKIWNSLSVETKEEYGEDYRNDFERAWEAGVNVVANPNIGWVVDCYSHALFSWWPRLRYCPGWDAIFMFIPLSIFPTALQDWILAGLYKLNPGPSLTPAVLVKNKKRRSAIQWIQFLSQIAIIPLLYTIFFVKNTQKQTVETSTHHHNVTVSE
What is the function of this protein?
3beta-hydroxysteroid dehydrogenase that converts 3beta-hydroxysteroids to 3-ketosteroids, an essential step in the production of dafachronic acids from cholesterol.  Catalyzes the dehydrogenation of lathosterol (5alpha-cholest-7-en-3beta-ol) to lathosterone (5alpha-cholest-7-en-3-one), a step required for maximal biosynthesis of Delta(7)-dafachronic acid (PubMed:22505847).  Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth, they can also regulate C. elegans lifespan (PubMed:22505847, PubMed:22505849).
What are the official names of this protein?
3beta-hydroxysteroid dehydrogenase dhs-16.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HUTG_STAA9
Sequence: MYKQGEPNLWTGRLDSETDPKKFRHFQTVTFEDLSKLEKSSMPSGVGILGYAVDKGVALNKGRIGAKEGPDAIKQAFAGLPDLNQCETLVDYGNVYHDHEELIDTQKEFAMLAAKSIANHRQTFLLGGGHDIAYAQYLATRKVYPTQSIGVINIDAHFDTRAEQQSTSGTSFRQILEEDENTDYLVLGIAQGGNTQSLFDYAKEKKIDYVFADELLSHVSPTIKDMIERFVHEHDVIMFTICMDVIDSAFAPGVSAPAVLGLYPHTVLELAKRIIPSDKVSSVSIAEMNPTYDADNRTAKLVANLVHHFLK
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: RS18_BACTN
Sequence: MAQQTQSEIRYLTPPSVDVKKKKYCRFKKSGIRYIDYKDPEFLKKFLNEQGKILPRRITGTSLKFQRRIAQAVKRARHLALLPYVTDMMK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RECU_STRMU
Sequence: MVNYPHHFIRKQSKPSQISKTINFANRGMSFEAAINATNNYYLSQKIAVIHKKPTPIQIVRVDYPRRSRAKIVEAYFRQASTTDYSGVYKGYYIDFEAKETRHKTSIPMKNFHAHQIKHMSQVLDQKGICFVLLHFSTLRETYLLPASHLIHFYRIDNGGKSMPLDYIKKNGYQVNVSAFPQVPYLDIIDKNILGGD
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINE_HELPG
Sequence: MSLFDFFKNKGSAATATDRLKLILAKERTLNLPYMEEMRKEIIAVIQKYTKSSDIHFKTLDSNQSVETIEVEIILPK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: NIBA3_HUMAN
Sequence: MGPDRKEVPLSRGTQAVVVGKGRGAPGDDSSMGGRPSSPLDKQQRQHLRGQVDTLLRNFLPCYRGQLAASVLRQISRELGPQEPTGSQLLRSKKLPRVREHRGPLTQLRGHPPRWQPIFCVLRGDGRLEWFSHKEEYENGGHCLGSTALTGYTLLTSQREYLRLLDALCPESLGDHTQEEPDSLLEVPVSFPLFLQHPFRRHLCFSAATREAQHAWRLALQGGIRLQGIVLQRSQAPAARAFLDAVRLYRQHQGHFGDDDVTLGSDAEVLTAVLMREQLPALRAQTLPGLRGAGRARAWAWTELLDAVHAAVLAGASAGLCAFQPEKDELLASLEKTIRPDVDQLLRQRARVAGRLRTDIRGPLESCLRREVDPQLPRVVQTLLRTVEASLEAVRTLLAQGMDRLSHRLRQSPSGTRLRREVYSFGEMPWDLALMQTCYREAERSRGRLGQLAAPFGFLGMQSLVFGAQDLAQQLMADAVATFLQLADQCLTTALNCDQAAQRLERVRGRVLKKFKSDSGLAQRRFIRGWGLCIFLPFVLSQLEPGCKKELPEFEGDVLAVGSQALTTEGIYEDVIRGCLLQRIDQELKKTLGANDVSCTLDGCLEVPWEQEGAAPNLNLVSSFLAGRQAFTDFLCLPAKSSANWILAASLLSCSCFRSGFHRDSRVFLVQLAEGLSHSLETVSSHSVWSFRPTPRQ
What are the official names of this protein?
Protein Niban 3, B-cell novel protein 1, Niban-like protein 2, Protein FAM129C.
What is the protein family that this protein belongs to?
Belongs to the Niban family.
Protein: HOP2_MOUSE
Sequence: MSKSRAEAAAGAPGIILRYLQEQNRPYSAQDVFGNLQKEHGLGKAAVVKALDQLAQEGKIKEKTYGKQKIYFADQNQFDTVSDADLHGLDASIVALTAKVQSLQQSCRHMEAELKELTSALTTPEMQKEIQELKKECAQYTERLKNIKAATNHVTPEEKEKVYRDRQKYCKEWRKRKRMTTELCDAILEGYPKSKKQFFEEVGIETDEDHNVLLPDP
What is the function of this protein?
Plays an important role in meiotic recombination.  Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis.  The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA.  This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA.  This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing.  May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
What are the official names of this protein?
Homologous-pairing protein 2 homolog, PSMC3-interacting protein, Proteasome 26S ATPase subunit 3-interacting protein, Tat-binding protein 1-interacting protein, TBP-1-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the HOP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TLK2_MOUSE
Sequence: MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYDTSQGKGTPRGHKISDYFERRAEQPLYGLDGSAAKEASEEQSALPTLMSVMLAKPRLDTEQLAPRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
What is the function of this protein?
Testis-specific isoforms may play a role in spermatogenesis.  Highly expressed in embryos throughout development.
What are the official names of this protein?
Serine/threonine-protein kinase tousled-like 2, PKU-alpha, Tousled-like kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Protein: XYNY_ACETH
Sequence: MKNKRVLAKITALVVLLGVFFVLPSNISQLYADYEVVHDTFEVNFDGWCNLGVDTYLTAVENEGNNGTRGMMVINRSSASDGAYSEKGFYLDGGVEYKYSVFVKHNGTGTETFKLSVSYLDSETEEENKEVIATKDVVAGEWTEISAKYKAPKTAVNITLSITTDSTVDFIFDDVTITRKGMAEANTVYAANAVLKDMYANYFRVGSVLNSGTVNNSSIKALILREFNSITCENEMKPDATLVQSGSTNTNIRVSLNRAASILNFCAQNNIAVRGHTLVWHSQTPQWFFKDNFQDNGNWVSQSVMDQRLESYIKNMFAEIQRQYPSLNLYAYDVVNEAVSDDANRTRYYGGAREPGYGNGRSPWVQIYGDNKFIEKAFTYARKYAPANCKLYYNDYNEYWDHKRDCIASICANLYNKGLLDGVGMQSHINADMNGFSGIQNYKAALQKYINIGCDVQITELDISTENGKFSLQQQADKYKAVFQAAVDINRTSSKGKVTAVCVWGPNDANTWLGSQNAPLLFNANNQPKPAYNAVASIIPQSEWGDGNNPAGGGGGGKPEEPDANGYYYHDTFEGSVGQWTARGPAEVLLSGRTAYKGSESLLVRNRTAAWNGAQRALNPRTFVPGNTYCFSVVASFIEGASSTTFCMKLQYVDGSGTQRYDTIDMKTVGPNQWVHLYNPQYRIPSDATDMYVYVETADDTINFYIDEAIGAVAGTVIEGPAPQPTQPPVLLGDVNGDGTINSTDLTMLKRSVLRAITLTDDAKARADVDKNGSINSTDVLLLSRYLLRVIDKFPVAENPSSSFKYESAVQYRPAPDSYLNPCPQAGRIVKETYTGINGTKSLNVYLPYGYDPNKKYNIFYLMHGGGENENTIFSNDVKLQNILDHAIMNGELEPLIVVTPTFNGGNCTAQNFYQEFRQNVIPFVESKYSTYAESTTPQGIAASRMHRGFGGFSMGGLTTWYVMVNCLDYVAYFMPLSGDYWYGNSPQDKANSIAEAINRSGLSKREYFVFAATGSDHIAYANMNPQIEAMKALPHFDYTSDFSKGNFYFLVAPGATHWWGYVRHYIYDALPYFFHE
What are the official names of this protein?
Endo-1,4-beta-xylanase Y, Xylanase Y, 1,4-beta-D-xylan xylanohydrolase Y, XylY.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.