PharMolix/UniProtQA huggingface dataset:
Protein: MINC_BACC1
Sequence: MEEKKQQNVTIKGTKDGITLHLDDCCSFSELLKELDEKLSTHYYDGDGRSLIEVHVKVGNRYLTEVQQEEIRTLIRNKKNLVVDSIESDVITKEEAIAWKEETEIVPISKIVRSGQVLHVKGNLLLIGDVNPGGTVIAGGNIFVVGSLRGIAHAGYYGDSDAVIAASVMNPMQLRISDVAMRAPEEKEDGAEAAECAYINENNHIVVDRLQLLTHLRPNLTKLERGIV
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RS19_BACLD
Sequence: MARSLKKGPFVDDHLMTKIEKLNEADKKQVVKTWSRRSTIFPQFIGHTIAVYDGRKHVPVYISEDMVGHKLGEFAPTRTYKGHASDDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ZNF98_HUMAN
Sequence: MPGPLGSLEMGVLTFRDVALEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFVGIAASKPDLITCLEQGKEPWNVKRHEMVTEPPVVYSYFAQDLWPKQGKKNYFQKVILRTYKKCGRENLQLRKYCKSMDECKVHKECYNGLNQCLTTTQNKIFQYDKYVKVFHKFSNSNRHKIGHTGKKSFKCKECEKSFCMLSHLAQHKRIHSGEKPYKCKECGKAYNEASNLSTHKRIHTGKKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKIIHAGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKFYKCEECGKAFSRLSHLTTHKRIHSGEKPYKCEECGKAFKQSSTLTTHKRIHAGEKFYKCEVCSKAFSRFSHLTTHKRIHTGEKPYKCEECGKAFNLSSQLTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTGEKPYKCEECGKAFNQSSHLTTHKMIHTGEKPYKCEECGKAFNNSSILNRHKMIHTGEKLYKPESCNNACDNIAKISKYKRNCAGEK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 98, Zinc finger protein 739, Zinc finger protein F7175.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FMT_ANASK
Sequence: MRIAFLGTPAFAVAALDALDWAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVLQPEKVRDGTLAAALRALAPDALVVAAYGRILGKDLLTLAPHGAINVHGSLLPRWRGAAPIQWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIREDDTSETLAPRLAALGGEALVEALRLLEAGAIVPVRQDAAQATLARILEKEDGRIAWTSPARRVSDRLRGFTPWPGAFTTLEGRTLKVLEARPGADAEAPAGEPGEAEVVPGRGLAVACGGGTALLVTRVQLEGRPAQSALDLANGLRRKRFRLGT
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RPOA_AERHH
Sequence: MLGSVTDFLKPRLVDIEQVSPTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSSKEGVQEDILEILLNLKGIAVKLEGKDEVTLSLTKSGTGPVTAGDITHGDEVEIVNPEHVICHLTGANAEISMRLKVQRGRGYVPASARVHNDDEERPIGRLLLDSAFSPIVRIAYNVEAARVEQRTDLDKLVIDMETNGTLDPEEAIRRSATILAEQLEAFVDLRDVSVPEKKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: ISPE_HELPH
Sequence: MMHVFEVYPKVNIFLKILHKEGAYHKLISRMCLVKDKLKDIISVKSALSFSLKGDFDCPLEENSLFKALQILKNFLKSKNFSHSAIKSLDTLAIEVEKNIPTQAGLGGGSADAGGLLYHLNHIFDWRLSLEELYSMGSLVGADTNFFISQHKSANATSYGEVIENFEEEPLENRLEIYAPNHVFCSTKAIYQAYKPETCFSQTKEWLKKPSLECLKTCDRSELNDLLKPALLTNQALRDIESELGKEWFFSGSGSAFFRLKNTQKGANETHCQQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: SYGB_LISMC
Sequence: MSKDFLLEIGLEEMPAKYVTSSVLQLEKRVTDWLKDNQIEFKEIKTYSTPRRLTVLVEEMAEEQANRVEEAKGPAKKIALDDEGNWSKAALGFAKSQKVAPEDLTFREIKGVEYIYIKKEVIGEKTTALLPSLEKVVTSMTFPVSMHWGSNDLRYIRPIKWLIAMFGEEIIPFEITGVSTSNTSRGHRFLGKTATINQPSDYPNALLEQFVVVNASERKQAIVEQLRELETMENWQIREDDDLLEEVTNLVEYPTVLAGNFEKEYLELPEEVLITTMKEHQRYFPVFSQEGELLPHFVTVRNGNHENLDTVARGNEKVLRARLSDADFFYQEDLKITIDEAVAKLQNIVFHEKLGTLTEKMKRVQKVALMLADYLNWQEEDKQDIIRLTNIYKFDLVTNIVGEFPELQGLMGEKYALLQGEKPAIATAIREHYLPSSAEGDLPQTDLGSLIAIADKLETLIGFFCVNIAPTGSADPFGLRRSAFGAVRIIQANGWDIPMLEVVSRIVDMERAEGATELPSSDVIKEVQTFLKNRLRVILQGHHIRHDIIDAVIGGDPNMIPQLIDRAQILNKHADAEWFRPTIEALTRVVNISKKYEDGVEVDPSLFENEYEQALFDKLEKLKFDFAGLKIVDRLKAFADLRTTIDAYFDNTLVMTDNDELKNNRLALLFELASFIKEFAQMDEINVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_POLNS
Sequence: MARYLGPKAKLARREGTDLFLKSARRALSDKCRLDNKPGQDGRTSGSRTSDYGNQLREKQKVKRIYGVLERQFRRYFAEAERRKGNTGETLLQLLESRLDNVVYRMGFGSTRAEARQLVSHCAILLNGNPVNIPSIQVKPGDVVAIREKAKKQARITESLNLVGQMAAVTWVSVDVAKLEGTFKQVPDREDISGEINESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL16_LACP3
Sequence: MLVPKRVKHRREFRGKMRGAAKGGRNVDFGEYGLEALESHWITNRQIEAARVAMTRYMKRGGKVWIRIFPHKSYTSKGVGVRMGNGKGAPTGWVAVVKREKIMFEVGGVSEAVAKEALRLASNKLPIRTKIVSREEVGGQSNEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DAPA_THEP1
Sequence: MFRGVGTAIVTPFKNGELDLESYERLVRYQLENGVNALIVLGTTGESPTVNEDEREKLVSRTLEIVDGKIPVIVGAGTNSTEKTLKLVKQAEKLGANGVLVVTPYYNKPTQEGLYQHYKYISERTDLGIVVYNVPGRTGVNVLPETAARIAADLKNVVGIKEANPDIDQIDRTVSLTKQARSDFMVWSGNDDRTFYLLCAGGDGVISVVSNVAPKQMVELCAEYFSGNLEKSREVHRKLRPLMKALFAETNPIPVKAALNLMGFIENELRLPLVPASEKTMELLRNVLKESGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANTR_TRASC
Sequence: DLLEALSQDQKLLMAKFLPHIYAELANREGNWHEDAALRPLHDHDYPGWMDF
What is the function of this protein?
May control digestion processes.
What are the official names of this protein?
Gastrin/cholecystokinin-like peptide, Antral peptide.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMU_XANOR
Sequence: MTLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQVQAAFADQSDLQWAAQREQLGTGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELADPTGYGRILRDAEGKVAAIVEQKDANDEQRRIRTINTGILTAESTALRRWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQLRTARALCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVITEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAFVGSNSALVAPIEIGANSTIGAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_BART1
Sequence: MVSSKDIIQRRARRVRRRIKMVSHDRPRLSVYRSNQNIYAQVIDDLRGCTLVSASTLESDLKKSLKSGADKEAAFAVGKLIAERAKKAGVNEVVFDRGAYVYHGRVKALAEAAREGGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: T176B_RAT
Sequence: MAQATVTVDGVKVTSTRPQSAQISIHIHHKSALEQLLGAMGSLKKFLSYPQARIHYGQLSLGVTQILLGLVSCVLGVCLYFGPWTELCASGCAFWSGSVAILAGVGIVIHEMGQGKLSGHISRLLLLACSATAAAATVMGVKSLIWQTSASYYFEISSTCDSLQPSIVDRFRSVRFTDDSDWRTERCREYLRMMMNLFLAFCILFTVICILKIVVSVASLGLSLRSMCGRNSQVLNDEETEKKLLGGDSAPASPTKEKIPVTP
What is the function of this protein?
Required for the development of cerebellar granule cells (By similarity).  May play a role in the process of maturation of dendritic cells.
What are the official names of this protein?
Transmembrane protein 176B, Protein LR8, Tolerance-related and induced transcript protein.
What is the protein family that this protein belongs to?
Belongs to the TMEM176 family.
Protein: S52A2_MOUSE
Sequence: MAAPPLGRLVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYLSVLVALGNLGLLLVTLWRRLARGKGEQVPIRVVQGLGIVGTGLLASLWNHVAPVAGKPYSVAFLTLAFVLALACCASNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALGQGVGRLECLHVPANRTTGPPIEVSPINFPERFSATTFFWVLTALLGTSAAAFQGLLLLLPSPTSEPTTGTGLRVETPGTEEEEEEEEASPLQEPPGQVAGIVSSPDPKAHQLFSSRSACLLGLLAITNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSCANPLACFLAMAVLCRSLAGLCGLSLLGMLLGSYLMTLAALSPCPPLVGTSAGVVLVVLSWVLCAGTFSYIKVAISSMLHSGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYRVFRSGKDCVDQCGL
What is the function of this protein?
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.  May also act as a receptor for 4-hydroxybutyrate.
What are the official names of this protein?
Solute carrier family 52, riboflavin transporter, member 2, Porcine endogenous retrovirus A receptor 2 homolog, PERV-A receptor 2 homolog, Protein GPR172B, Riboflavin transporter 1, mRFT1.
What is the protein family that this protein belongs to?
Belongs to the riboflavin transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTS_BRUO2
Sequence: MENAGPDAPVRLTPMMEQYIEIKAANVDSLLFYRMGDFYELFFDDAVAASAALGITLTKRGKHLGEDIPMCGVPVHAADDYLQKLIAKGYRVAVCEQVEDPAEAKKRGSKSVVKRDVIRLVTPGTLTEEKLLDPAQANFLMAMGRTRGDGALALAWIDISTGTFRVAETTPDRLFADIMRVDPRELVVADSAFHDEELRPVFDLIGKAVTPQPATLFDSAAAQTRIQHYFNVATLDGFGQFSRPELSAISGAIAYIEKTQISERPPLMRPEREHEGGTLFIDPATRASLELARTMSGKRDGSLLKAIDRTVTGGGARLLAERLTAPLTSPKEIAPRLDSVSWCLSEQTLCEALRLELKGVPDMPRALSRLAVGRGGPRDLGALACGFEAAGGIASLLDGALLPDELAAAREAIEKMPAGFAAHLDRALADELPLLKRDGGFVREGYNSELDEMRALRDQSRRVIAGLQADYIEETGIKSLKIKHNNVLGYFIEVTANNSGAMTDTDEAKSRFIHRQTMANAMRFTTTELAELESKIANAADRALSIELAIFEELTAEAVAHADSIRAAASALSVFDVSTALAVLAEEQGYCRPHVDDSLSFNIVAGRHPVVEQALRRQAANPFVANDCDLSPQRDGGDGAIWLLTGPNMGGKSTFLRQNALIAILAQMGSFVPAGSAHIGVVDRLFSRVGASDDLARGRSTFMVEMVETAAILNQAGEHSLVILDEIGRGTATFDGLSIAWAAVEYLHEKNRCRALFATHFHEMTALSEKLERLSNVTMRVKEWDNDVIFLHEVAKGAADRSYGVQVARLAGLPEAVVNRARDVLHQLEAGETSGKADRLIDDLPLFSVMLQQEKPKPQIQAKDSELANAVAAISPDELTPREALDLIYKLKELAGKA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: FIS_SHEB2
Sequence: MFDQTTNTEVHQLTVGKIETANGTIKPQLLRDAVKRAVTNFFAQLDGQEAQEVYEMVLSEVEAPLLDIIMQHTRGNQTRAANMLGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: FPPS1_PARAR
Sequence: MSSDLKSRFLQVYDTLKSELINDPAFEFDDDSRQWVEKMLDYNVPGGKLNRGLSVIDSYQLLKGGELTDNEIFLAAALGWCIEWLQAYFLVLDDIMDESHTRRGQPCWFRLPKVGMIAANDGIILRNNVPRILKKHFRGKPYYVDLLDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLSIHRRIVQYKTAYYSFYLPVACALLMFGEDLEKHEEVKNVLVEMGTYFQVQDDYLDCFGAPEVIGKIGTDIEDFKCSWLVVKALELSNEEQKKILHENYGKKDPSSVAKVKELYHTLNLQGVFEDYENTSYKKLITSIEGHPSKAVQAVLKSFLGKIYKRQK
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
What are the official names of this protein?
Farnesyl pyrophosphate synthase 1, FPP synthase 1, FPS 1, (2E,6E)-farnesyl diphosphate synthase 1, Dimethylallyltranstransferase 1, Farnesyl diphosphate synthase 1, Geranyltranstransferase 1.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Rubber particles.
Protein: RNZ_CLOK1
Sequence: MLDVCLLGCGGSMPIPDRNLTAMIVSYQGRKLLIDCGEGTQVSLKILGWKIRNIDVILFTHFHADHIAGLPGLLLTIANSGRLEPITIIGPYGLIKIVMGLKVIAPVLPYSIELVELHGKEKYFQKIGYFNINILSVDHGIPCFAYSIDVQRNRKFDREKALKNKVPLIFWSKLQKGEEIKQRDKLYTPDMVLGYGRRGLKISYCTDSRPSRELVEFVKKSDVFICEGMYGDDEKKHKAISYKHMIFSEAAVIAKEAEVEELWLTHFSPSLIEPQAYIENAKNIFKNTIIGQDRYVKSINFKE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: ACTZ_PIG
Sequence: MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGWSLPSAPCPRKLPQSCQAQTPREMTRESPFLPIQVLVTGY
What is the function of this protein?
Part of the ACTR1A/ACTB filament around which the dynactin complex is built.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Alpha-centractin, Centractin, ARP1.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP1 subfamily.
Protein: SLU7_RAT
Sequence: MSAAAVDPVSATPMTGSKEMNLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPDEHIQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKESVNSEECIINDATGEEPVKKPQTLMELHQEKLKEEKKKKKKKKKHRKSSSDSDDDEERKQEKLKKALNAEEARLLHVKEIMQVDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron.  Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region.  May be involved in the activation of proximal AG.  Probably also involved in alternative splicing regulation.
What are the official names of this protein?
Pre-mRNA-splicing factor SLU7.
What is the protein family that this protein belongs to?
Belongs to the SLU7 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
Protein: CF226_HUMAN
Sequence: MERPRSPQCSAPASASASVTLAQLLQLVQQGQELPGLEKRHIAAIHGEPTASRLPRRPKPWEAAALAESLPPPTLRIGTAPAEPGLVEAATAPSSWHTVGP
What are the official names of this protein?
Uncharacterized protein C6orf226.
Protein: DHMA1_MYCBO
Sequence: MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase 1.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: DEL10_CAEEL
Sequence: MVRMAERLAENFIPEANQRNENEPAYSRYKRVGQNRSRLNSRASLGSSMGRRITLIETDSGVIEVESDKQFLDAFKDANMDAVHHLNAASPVTRGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIEAEYPSKISFPTVAICNNNQFRLTYLTGGRIMNRRSKSISGSLLSTGHDVESVFDTVLRKSWDMDAVKFLRSAAHWKSRMILGCTWPNGTSCKLSDFKAVWTTTGLCWAINTDPHNPYEVTGSGEGHGLRLLLNVESYERVDACTKHFRTKTLPGLKILIYNQTDIPDSSMNGVNVPSGYSMDIPFKMQHRSKLTGVHCIEENDEQIEASTDFNNPENIRTCTLRRYMTEVENSCHCTLRRAYTSNSTDVKMKACNVDQYFGCAQKAMQRIREEGTASTCLPPCKSIDYTAWQDMNRLPQNLMPALIEEQEEDDEDDVEQEELDENVSFSTVSGGETFSCEDSAYLDDKQVMRIKRDAHRAYEMQARHQEDIFLRSRRLIARLRNAINSIERYKWGWHYDTFSGVADRLSNLTCFSNFSERHRDIISILESRPITSEEKKANQMFFLLDETAFNRNATRYMSVGDLKSRYGDKVDDVAEEIAVILRIMEKLWHVFMPDSYIRTMTGDFSRMDRIIELMNQYELNKLQRRAWAEKMQSRQMKHFFEDDFYESYYQPLIKDLDTTLVKQIDEVEADWPKVEYYLQRGSAGKTGAIMFFGDGNKDNRQKFEKLIVEMHECASGKMRKEAGKMLSSFKKSYRELQAAYGKLFKEELPDYLENFQFGNKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEIVYLCIQYGLCGKRARNMKCIPMDALTRQMKKVATCSCCKKPIEKSREPIYKKKSQSYQRRFTADDEDQGDKFRSRASSEESKRRKNIWAQMNDPSGNSTLTPSEIKNFLDQVQRNSQPPSYHDDHHPEDHYYYNDPNYLTISPPSDRPEDNREGSTSGYYSSPRAPPQANPRDESPIPDTEPISVSEFSDALAPPLFKTPPRERRTRKEQKIDEEDDDKHSYV
What are the official names of this protein?
Degenerin-like protein del-10.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: SHO1_CLAL4
Sequence: MGFRMANFLGDPFAISTVSFGVIAWIVAIAGAGSSASDNFPRFTWWGLVYEILLIIMVFLLYLNNTIELYKFTLVGLLSVGFLYTTNSTNNLIYSSNSGNLCCAAGCILLSMLNFLWIVYFGGHPESPSNQFIDSFAMKSSYAQQLPSEKNDDHEFAVPRSASGSQGFGVSDSRHSQLTNSKSGYMSSSQLNGLENFSHTNVQNTGTVGASNPASMPNTVYNTNGTNTADSNFAVPVSTFRYKARALYSYDASPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLD
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_METRJ
Sequence: MRHAYRGRRFNRTAEHRKAMFANMSAALIKHEQIITTLPKAKDLRPVVEKLITLGRIDSVHTRRLAMAQLRDADMVKKLFTVLGPRYKGRPGGYCRIMKAGFRQGDNAPLAVIEFVDRDVDARGKDSGPSQVADAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ATPG_NEIMA
Sequence: MAVGKEILTKIRSVQNTQKITKAMQMVSTSKMRKTQERMRLARPYAEKVRMVMSHLAQTNTDHGIPLLESHREIRRVGFILITSDKGLCGGLNANVLKKFLAQVQEYQNQGIEEEIVCLGSKGLMACQSIGLNVVASAVNLGDTPKMEMLLGPLTELFQRYEKHEIDRIHLVYSGFVNTMRQEPRMEVLLPIGENVIGDSAPKSPFSWEYRYEPTALAVLEYLVRRYLESVVYQALSDNMASEQAARMVAMKAATDNAGNAIKELRLVYNKSRQAAITTELSEIVAGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HAP28_MOUSE
Sequence: MPKGGRKGGHKGRVRQYTSPEEIDAQLQAEKQKANEEDEQEEGGDGASGDPKKEKKSLDSDESEDEDDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK
What are the official names of this protein?
28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PAP, PDGFA-associated protein 1, PAP1.
What is the protein family that this protein belongs to?
Belongs to the PDAP1 family.
Protein: PTH_ACIB3
Sequence: MSNISLIVGLGNPGSEYAQTRHNAGFWFVEQLADKYGITLKNDPKFHGISGRGNIEGHDVRLLLPMTYMNRSGQSVVPFSKFYQIAPEAILIAHDELDMNPGVIRLKTGGGHGGHNGLRDIVPHIGPNFHRLRIGIGHPGSKERVSGHVLGKAPSSEQSLMDGAIDHALSKVKLLVQGQVPQAMNQINAYKPA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX3_RAT
Sequence: MLRSMWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKLREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSIVAVYSTCMLVVLLRVQLNIIGGYIYLDNATVGKNGTSILAPPDVQQQYLSSIQHLLGDGLTELVTVIKQAVQRILGSISLKHSLSLLDLEQKLKEIRTLVEQHRSCWNDKDASKSSLCHYMMPDEETPLAAQAYGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSINSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLMMEQVKDFAANVYEAFSTPQQLEK
What is the function of this protein?
Involved in peroxisome biosynthesis and integrity.  Assembles membrane vesicles before the matrix proteins are translocated.  As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
What are the official names of this protein?
Peroxisomal biogenesis factor 3, Peroxin-3, Peroxisomal assembly protein PEX3.
What is the protein family that this protein belongs to?
Belongs to the peroxin-3 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.