PharMolix/UniProtQA huggingface dataset:
Protein: VE2_HPV21
Sequence: MENLSDRFNVLQDQLMNIYESAANTIESQIEHWQTLRKEAVLLYFARQKGVTRLGYQYVPPLAVSESRAKQAIGMMLQLQSLQKSEYAKEPWSLVDTSAETFRSPPENHFKKGPVSVEVIYDNDKDNANAYTMWRYVYYVDDDDQWHKSPSGVNHTGIYFMQGTFRHYYVLFADDASRYSRTGHWEVNVNKETVFAPVTSSTPPDSPGGQADSNTSSTTPATTTDSTSRLSSTRKQSQQTNTKGRRYGRRPSSRTRRTTQTHQRRRSRSKSRSRSRSRSRLRSRSRSRSRSYSRSRSQSSDQPQYRFRSGGQVSLITTATTTTTTATNYSTRGSGRGSSSTSSSTSKRPRRPRGGAIGGSSGRGRRSSSTSPSPSKRSRGKSESVRQRGISPDDVGKSLQSVSTRNTGRLGRLLDEALDPPVILVRGEPNTLKCFRNRAKLKYAGLYKAFSTAWSWVAGDGTERLGRSRMLISFFSFEQRKDFDKTVKYPKGVDRSYGSFDSL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RS20_SHESM
Sequence: MANSKSAKKRALQSEKRRQHNASRRSMLRTYVKKVIAAIKAGDHKTATEAFAAAQPIVDRMATKGLIHKNKAARHKARLNAKIKALAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CLPP_ATRBE
Sequence: MPIGVPKVPFRSPGEEDASWVDVYNRLYRERLLFLGQGINSEISNQLIGLMVYLSIEDETKELYLFINSPGGWVIPGIAIYDTMQFVRPDVHTVCMGLAASMGSFILVGGEITKRLAFPHARVMMHQPASGYYEAQTGEFVLEAEELLKLRETLTRVYVQRTGKPLWVVSEDMEKDVFMSATEAQAYGIVDLVAVE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: SSPA_HAEDU
Sequence: MTISANKRSVMSLFSDKNDIYSHQVRIVLAEKGVPYELENINPNTISEDFLELNPYANIPTLVDRDLVLFNSRIIMEYLDERFPHPPLMPVYPVLRGKSRLTMHRIEQDWYSLIDIVNKNPESKEAKKALSQLREEMLALGSVFAATSYFMSDEFSLVDCYIAPLLWRMHNLGVQFTGAGGKAIKAYMTKVFQRDSFSQSIGGSAPKHLMDDKE
What is the function of this protein?
Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.
What are the official names of this protein?
Stringent starvation protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. HSP26 family.
Protein: MP1_TALMA
Sequence: MKFLSSLVVLGLSAQALASPYVDHQATKDQRDVNVFKQVLQDINLDVQKFDQDITQYQGGDPTVLLADSDAIIKTTEEGIQRIGPQPPLSVTEALALVGPVQGVNKLIMKAVDHLIEKKGPLVGGGYGPQVKDSLERQAHAASKLSELVSSKVPSPLAPISKQLSDQVAQALQKGIQAFSISARQATKVKREATKVQRDISAFKKVIQNISLAVNKFNVDIERYVGGDASHLLADGNVLIKATLDGVQSLQNEPPLSSMEALALVGPVQDLSNQILLAIQNLIDKKEPLVQAGFGGKVENNLRQQEEAAQKLSELVSTKVPHELADISRQLSDGIAAGIKKGIDAFAGTGPAPTTSSTPEASTAPAPSTPPQTPEDTLVPATSTPAPGPAPTAPDSSMVWPTSTTASPDVQPTITSSGTSVPAAPTGGNSSPAVPAFTGAASANQVSGAVGLAAGLLAVLAF
What is the function of this protein?
Constitutive protein of the cell wall.  Binds fatty acids and may thus serve as a fatty acid transporter between P. marneffei and host cells during infection (PubMed:20053994).  Abundant antigen target of host humoral immune response (PubMed:9488383).
What are the official names of this protein?
Cell wall mannoprotein 1.
What is the protein family that this protein belongs to?
Belongs to the cell wall mannoprotein 1 family.
Protein: MATK_ALLPE
Sequence: MXXXXGYLEFDGARQQSFLYPFFFREYIYVLAYDHRLNRLNRNRSIFLENADFDKNYSSLIVKRLILRMYEQNRLIIPTKDLNQNPFFGHTNLFYYQMISVLFAVIVEIQFSLRLGSSFEGKQLKKSYNLQSIHSIFPFLEDKLTHFNYVLDVLIPYPIHLEILVQTLRYRVKDASSLHFFRFCLYEYCNWNNLDIKKKSILNPIFFLFLYNSHVCEYESIFFFLRKRSSHLRSTSYKVLFERIFFYGKIQHFLKVFVNNFPASLGLLKDPFLHYVXYHGKFILATKDTPLLMNKWKYYFVNLWQCYFSVWFQSQKVNINQLSKDNLDFLGYLSSLRLNPLVVRSQMLENSFLIDNVRIKLDSKIPISSIIGSLAKDKFCNVLGHPISKATWTDSSDSYILNRFVRICRNISHYYSGSEKKKNLYRIKYILRLCCVKTLARKHKSTVRAFLKRLGSGLLEEFLTGEGQVLSLIFPRSYYASKRLYRVRIWYLDILYLNDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GN_PSHV1
Sequence: MWLLRPAGSNFIVALIVLACAGPLTCSAQLDAGILNPWGSAGHNDAVMPGMFANSESDERFYSPHCSSRGLPLVNESMASVIFFLSLAMVCVAIVAILYNCCFNSFKNSVINSRW
What is the function of this protein?
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity.  Also plays a critical role in virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein N.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein N family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Protein: Y2284_GEODF
Sequence: MRILIITGLSGSGKSTAVRALEDEGFFCQDNLPVALFPTFVDLVDNAKERIRDVALVMDIRGRDFNKGFEKVFQEITEAGHLVDILFFDATDEVIIRRFSETRRRHPAIDSGSVPEGIRSERQQLAGLRSFATQIIDTSELNVHQLKDLVISLVKGGEGGREMTVHLQSFGYRFGLPLESDLVMDVRFLPNPYFIPELKEFSGLDPKVRAYVLKHDETGEFLTKFKELLEFLLPGYKREGKSYLTISIGCTGGRHRSVVIAEEIRDFFKRKQLNLKVSHRDMEKG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Geob_2284.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: HFLD_SALPB
Sequence: MAKNYYDITLALSGICQSARLVQQLAHQGHCDADALHVSLNSVIDMNPSSTLGVFGGSEANLRLGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALNTLGDRINGLQRQLDHFDLQSDTLMSAMAGIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRASLLAGIRAAVLWHQVGGGRLQLMFSRHRLTTQAKQILAHLTPEL
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LEUD_SHEAM
Sequence: MQAFTTHTGLAVAIDSANIDTDQIIPKQFLSKVTKDGFGIHLFHDWRYLDDAGDIPNPEFNLNKPRYKGATILLAQENFGCGSSREHAPWALADFGLRAIIAPTFADIFYGNAINNGLLPVRLPEAAVRQLMDEVEANEGAEVTVDLENLKVVSPSGAEFSFTLAESARQNLLKGLDAIGLTLAHEAAISEYESRIPAWRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CDKA_CONGR
Sequence: MPKQEKMMLVLLILPLPYCNAAGVTTVQWGGHGDGLDRYLQRGVRDVHRPCQSVRPGRVWGKCCLTRLCSTMCCARADCTCVYHTWRGHGCSCVM
What is the function of this protein?
Alpha-D-conopeptides act as non-competitive inhibitors of nicotinic acetylcholine receptors (nAChR).  This toxin has strong inhibitory activity on rat alpha-9-alpha-10 (CHRNA9-CHRNA10) (IC(50)=1. 2 nM) and a moderate inhibitory activity on human alpha-7 (CHRNA7) (IC(50)=210 nM), rat alpha-3-beta-2 (CHRNA3-CHRNB2) (IC(50)=498 nM), rat alpha-3-beta-4 (CHRNA3-CHRNB4) (IC(50)=614 nM) and rat alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRNE-CHRND) (IC(50)=743 nM) subtypes.  Shows a weaker inhibitory activity on human alpha-9-alpha-10 (IC(50)=28 nM) than on the rat channel.  This is explained by a different residue in the probable binding site (His-31 in rat alpha-10 and Leu-31 in human).
What are the official names of this protein?
Alpha-conotoxin GeXXA, Alpha-D-conotoxin GeXXA, Ge-5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin D superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: METAA_GEOKA
Sequence: MPINIPKDLPAKEILEQENIFVMDEERAYSQDIRPLNIIILNLMPEKEKAETQLLRLLGNSPLQVNVTFLRPATHEPKTTSKHHLEQFYTIFPHIRHRKFDGMIITGAPVEQMPFEEVNYWGELTEIMEWTKTNVTSTLHICWGAQAGLYYHYGIPKYPLPEKCFGVFNHTVEVKNVKLLRGFDDVFRMPHSRHTDVKREDIEKVPDLTILSMSDKAGVCLVASNDGRRIFLTGHPEYDATTLKEEYERDLAKGLPIHIPESYFPNDDPSQPPLNTWRSHANLLFVNWLNYYVYQETPYEWE
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_STAS1
Sequence: MAKENVCIVYGGKSAEHDVSILTAQNVLNAIDKEQYQIDIIYITNDGAWKKKENIVDTINDIDSLRLIDVEAGEISKLLSQGSTGNAYSAVFPLLHGPNGEDGTIQGLFEVLDIPYVGNGVLAASSSMDKLVMKQLFAHRGLPQLPYVSFLRSEYHKYEGNILKLVHDKLEYPVFVKPANLGSSVGISKCNNEEELKNGIEEAFQFDRKLVIEQGIEAREIEVAVLGNDYPETTWPGEVIKEVAFYDYKAKYKDGKIKLDIPADLDEEVQMTLRNMAVEAFKATDCAGLLRADFFVTDDNQIFINETNAMPGFTAFSMYPSLWENMGVSYSDLIKKLIELAKEKHEDKKQNKYKID
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_VITVI
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ITPK4_ORYSJ
Sequence: MAPELSSPSSSPRYTVGYALLPEKVSSVVRPSLVALAADRGVRLVAVDVSRPLAEQGPFDLLVHKMYDRGWRAQLEELAARHPGVTVVVDSPGAIDRLLDRATMLDVVSGLRTPVSVPPQVVVSDAAADADELLARAALRFPLIAKPLAVDGSAESHDMRLVYRRDGVLPLLRAPLVLQEFVNHGGVLFKVYVVGDRATCVRRSSLPDVPARRLLDLDAEPSVPFANISNQPLPPPDDDGGAADDDTPAAGFVDEVARGLRRGLGLHLFNFDMIRERSEEHGDRYFIIDINYFPGYAKMPGYEAALTDFFLEMLRGTRPVPEQLGPGSGLDMEARKLEPGLGIGLRELESGRAQA
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds.  Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase 4, Inositol 1,3,4-trisphosphate 5/6-kinase 4, Inositol-triphosphate 5/6-kinase 4, Ins(1,3,4)P(3) 5/6-kinase 4, OsITP5/6K-4, OsITPK4.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: MOS_DENAN
Sequence: PSVNARPCSSPLVCPAKGEKFFGVGSTSRIRRLPPHLAWCSIDWEQLCLLNLLGSGGFGSVYKATYHGATVAVKQVNRCSKNHLASRQSFWAELNVVRLDHNNVVRIVAASTCTPASQDSLGTIIMEYAGNCTLHHVIYGTGYLTGNSNDDLKCDHGFLSTAQAIIYSCDIVAGLMFLHSQLIVHLDLKPANIF
What are the official names of this protein?
Serine/threonine-protein kinase mos, Oocyte maturation factor mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CNDH2_HUMAN
Sequence: MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSSVQEDRANGVASSGVPQEAENEFLSLDDFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEKNNNPLYSRQGEVLASRKDFRMNTCVPHPRGAFMLEPEGMSPMEPAGVSPMPGTQKDTGRTEEQPMEVSVCRSPVPALGFSQEPGPSPEGPMPLGGGEDEDAEEAVELPEASAPKAALEPKESRSPQQSAALPRRYMLREREGAPEPASCVKETPDPWQSLDPFDSLESKPFKKGRPYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSFADMEVLYWTHVKEQLETLRKLQRREVAEQWLRPAEEDHLEDSLEDLGAADDFLEPEEYMEPEGADPREAADLDAVPMSLSYEELVRRNVELFIATSQKFVQETELSQRIRDWEDTVQPLLQEQEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEMAVDTMSLRLLTHQRAHKRFQTYAAPSMAQP
What is the function of this protein?
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007).  May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids.  Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation.  Required for decatenation of chromatin bridges at anaphase.  Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity).  Seems to have lineage-specific role in T-cell development (PubMed:14532007).
What are the official names of this protein?
Condensin-2 complex subunit H2, Chromosome-associated protein H2, hCAP-H2, Kleisin-beta, Non-SMC condensin II complex subunit H2.
What is the protein family that this protein belongs to?
Belongs to the CND2 H2 (condensin-2 subunit 2) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.
Protein: SPEE_ECOLU
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUFE_SALG2
Sequence: MAALPDKEKLLRNFTRCANWEEKYLYIIELGQRLAELNPQDRNPQNTIHGCQSQVWIVMRRNANGIIELQGDSDAAIVKGLMAVVFILYHQMTAQDIVHFDVRPWFEKMALAQHLTPSRSQGLEAMIRAIRAKAATLS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3HAO_RAT
Sequence: MERCVRVKSWVEENRASFQPPVCNKLMHREQLKIMFVGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGEHRDVVIRQGEIFLLPARVPHSPQRFANTMGLVIERRRMETELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPNPDQLLKEPPFPLSTRSVMEPMSLKAWLESHSRELQAGTSLSLFGDSYETQVIAHGQGSSKGPRQDVDVWLWQLEGSSKVTMGGQCVALAPDDSLLVPAGFSYMWERAQGSVALSVTQDPACKKPLG
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: LPXK_BART1
Sequence: MHISAPHFWWKNKSFLRFLLAPISWGYGYFSCRFMGRQPPVIDLPVLCIGNFTCGGTGKTPVVIAFAKVAKELGFVPGVVSRGYGGAVKGVHLVNEKYDTARDVGDEALLLAQHAFVAVSANRYAAAQRLKKEGCNLILMDDGFQSRRLYMDYTLLVVDAMRGFGNGAVFPAGPLRVPLKTQFSFMDSVLLIGHSDARDNVSFLIARTGKPLHRAHLKARASDEVAGKSFLAFAGIGNPDKFFQSIKELSGHVVQTYTYPDHYFFTDKNLTSLVQKAQMYNLWLATTAKDYIRIQTIHERKDLKNLIVFDVDVDFVQKDFCRMLLEEVITRFRKRSCEFSCAKGKG
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: THIC_AGRRK
Sequence: MNIAAKNITPTVTTGPLPASRKIYIPGDIHPDIRVPMREIGLHPTSGEPPVIVYDSSGPYTIEGADIRIEQGLLDLRRNWVLARGDVEAYQGRHVRPEDNGFASGERLTPEFPTLRQPLRAKDGKAVTQLAYARAGIITPEMEFIAIRENLGRKAQAEAMVRDGESFGAHIPDHVTAEFVRQEVAAGRAIIPANINHPEAEPMIIGRNFLVKINANIGNSAVTSSMAEEVEKMVWAARWGADTVMDLSTGRNIHNIREWIIRNSPLPIGTVPLYQALEKVEGIAENLTWEVYRDTLIEQAEQGVDYFTIHAGVRLHYIPLTVNRVTGIVSRGGSIMAKWCLHHHRESFLYEHFEEICDICRTYDVSFSLGDGLRPGSIADANDAAQFAELETLGELTKIAWAKDCQVMIEGPGHVPMHKIKENMDKQLAVCGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPDRNDVKTGVITYKIAAHAADLAKGHPAAQLRDDALSRARFEFRWEDQFNLSLDPETARSFHDETLPKEAHKVAHFCSMCGPKFCSMRISHDIRAEAQKEGLEAMAAKYREGGDLYMPVDAVEPSAG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: Y1841_ARCFU
Sequence: MGDNLKVIEADSVSYDYPDGSAGVREVSLEIFEGDRVGLIGANGSGKSTLILLLAGLLRPTKGKIRIFGREIDKKNVEEIRRKIGVVFQNPDDFLFNPTVRDELLYVPRQLEWSEEEMENAVKEYAEMFGITHLLNKPPFRLSGGEKKKVEIASVLIYKPEVLLLDEPTAYVDGKTKRLILKILEDFKGTLVIATHELDVAEKLADKFVLLNLEHRIEAAGGKEILKNEELLEKAGVI
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein AF_1841.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PIG7_CLAP2
Sequence: MSETHIPYRLDGKIALVTGSGRGIGAAMAVELGRLGAKVVVNYVNSVESAEKVVDEIKGLGSDAVAIQADVRQVSQIVELMDKAVKHFGGLDIVCSNSGVVSFGHFGDVTEEEFDRVFSLNTRGQFFVAREAYRHLNNGGRIILMSSNTAKDLSVPKHSLYSGSKGAIDSFVRIFSKDAGDKKITVNAVAPGGTVTDMFHSCSQHYIPGGDKYTAEERQAMAAHASPLTRNGFPLDIAKVVCFLASDEAEWVNGKVLTLDGGAA
What is the function of this protein?
Short chain dehydrogenase; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (PubMed:28955461).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity).  The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity).  The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity).  The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units (PubMed:32105084).  Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 (PubMed:28955461).  CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization (PubMed:28955461).  The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis (PubMed:28955461).  It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity).  Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 (PubMed:28955461).  Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin (PubMed:28955461).
What are the official names of this protein?
Short chain dehydrogenase CPUR_05429, Ergochrome gene cluster protein CPUR_05429.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: FLAB4_THEKO
Sequence: MRRRGAIGIGTLIVFIAMVLVAAVAAGVIIGTAGYLEQKAQAAGRQTTQEVASGIKVLNVYGYTNATPPSNGTIERMAIFITPNAGSEGIDLSNVKIVLSDGRRLVVYNYSGSFQNAESVKDLFNMTYVGVWNSTNGTASFGIAVINDIGSEMQGTHPTLEFGDMVALCVWTTMFEYEDKDGIGPSTRITGKVIPERGAAGVLDFTTPATFSYNVMVLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B4.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: Y3696_BACAC
Sequence: MTKNIHDVAYELQKAIAENDDFKTLKESYAAVQADAASKNLFDEFRTMQLSLQQKMMQGQEITEEDNQQAQEVVVRIQQDAKITKLMETEQRLNVVIGDVNKIIMKPLEELYSAQQQV
What are the official names of this protein?
UPF0342 protein BAMEG_3696.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.