PharMolix/UniProtQA huggingface dataset:
Protein: FER5_ZYMTI
Sequence: MTTTTTTTALTFTLPDGTSTVTIRPTQKAAPSEEPSQDTAPSKKDSNHEVYLNDHLIATWVIDPSVKTRVSPAQVLDERAEFDSVRHLVLSSRRSNDNGHTWISIYALWLLHHDLDVIPISSPSNSAVTTYLINTGLAAPSPFEPADTDAGRTLLLAREAFWQGAGTPDNLSWLRSRPEASIPGFNSHLGAFASQMSFTRRGNVCTTHPLRPQKPAPGTVVYSRYIVEVGQHLQLVHIDASNPVHFSAYARWQNSDRVNHGWRERGPDEKHAAYLESQRIDPHTMSLIFLWDGEPAGYSEVGWAKEDNTACFVSSNCGIHIGEFDQLSHILVGEEKFRGGKRYQAVATSIKHLCFLRDPRTTQVIAEPRFDLPSVPIQARFLPQERKKRVQLPHKQAVLFALQRERFFQEGHFY
What is the function of this protein?
Acyltransferase; part of the gene cluster 14 that mediates the biosynthesis of a ferrichrome A-like siderophore which may contribute to organismal virulence (Probable).  The first step of siderophore biosynthesis is performed by the HMG-CoA synthase (HMGS) MYCGRDRAFT_54740 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (By similarity).  The enoyl-CoA isomerase/hydratase MYCGRDRAFT_76805 then catalyzes the conversion of HMG-CoA to methylglutaconyl-CoA (By similarity).  The acyltransferase MYCGRDRAFT_85486 then fuses methylglutaconyl-CoA with hydroxyornithine to yield methylglutaconyl hydroxyornithine (By similarity).  Methylglutaconyl hydroxyornithine is then available for use by the nonribosomal peptide synthetase NRPS2 to generate the ferrichrome A-like siderophore (By similarity).
What are the official names of this protein?
Acyltransferase MYCGRDRAFT_85486, Ferrichrome A-like siderophore biosynthesis protein MYCGRDRAFT_85486.
What is the protein family that this protein belongs to?
Belongs to the lysine N-acyltransferase mbtK family.
Protein: ATPE_ACIBT
Sequence: MATMQCDVVSVKESIYSGAVTMLIAKGAGGELGILPGHAPLVTLLQPGPIRVLLENGTEEIVYVSGGVLEVQPHVVTVLADTAIRADNLDEAAILEARKNAEQLLANQKSDLDSAAALAALAETAAQLETIRKIKNRAQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ENO_SHIF8
Sequence: MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKFWRQNPAGCDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CAMPS_PINCO
Sequence: MALVSVAPLVSMRRSLFSSPYELKSIDKTIPNLVMCRKRMSGTPSIRVSSTTSASNDDGVRRRVGDYRYNHWDDDLIDSLATSYEAPSYLERADTLVEAIKDRFNSMGVEDGERISPLTDLYQRLWMVDSVERLGIDRHFQNEIKSALDYVFSYWKEKGIGRGRQSAVTDLNSTALGFRTLRLHGYPVSSDVLENFKDHNGQFTCSGIQTEGEIRGVLNLFRASLIAFPGEKVMEEAEIFSTMYLKHALQKIAVSSLSQEIEYLLDYGWHTNLPRLEARMYMDVFPQDTIYEQKLVELAKVEFNIFHSLQKRELQSLTRWWKHYGFPQLSFTRHIHVEYYTFASCVATDPKQSAFRLGFAKMSHFVTVLDDIYDTYGTMEELELFTAAIKRWDPSLVDCLPEYMKGVYMAVYDTVNEMAKEAEKVQGRDTLNYVRQAWEPYFDAYMIEAKWISSGYLPTFQEYLDNSKISFGSRITILQPILTLGEPLPHEILQEIDFPSKFNDLISVLLRLKGDTRCYKADRARGEEASSVSCYMKDNAGLTEEDAIHRINAMVHNLLKELNWELLKPDCNVPISCKKAAFDICRIFHHGYKYRDGYGDATIETKNLVKRTVLEPVPL
What is the function of this protein?
Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:23679205).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (-)-camphene, (+)-alpha-pinene and (-)-alpha-pinene, and, to a lower extent, to tricyclene, myrcene and (-)-beta-pinene (PubMed:23679205).
What are the official names of this protein?
(-)-camphene synthase, chloroplastic, (+)-alpha-pinene synthase 1, chloroplastic, (-)-alpha-pinene synthase 1, chloroplastic, (-)-beta-pinene synthase (-)camp/(+)alphapin1, chloroplastic, Myrcene synthase (-)camp/(+)alphapin1, chloroplastic, Terpene synthase (-)camp/(+)alphapin1, PcTPS-(-)camp/(+)alphapin1, Tricyclene synthase (-)camp/(+)alphapin1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PROAO_OLEEU
Sequence: MSWQTYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVCGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-1, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FOLD_STRGC
Sequence: MAELIDGKALAAKLQGKLAQKTAKLKEKTGQTPGLVVVLVGNNPASQIYVRNKERSALAAGFRSKVERLPEETSQEELLSLIETYNQNPDWHGILVQLPLPDHIDDEAVLLAIDPDKDVDGFHPLNMGKLWSGHPVMIPATPAGIMAMFHEYGVELEGKRAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKTAKRADILVVAIGRGHFVTKDFVKEGAVVIDVGMNRDENGKLIGDVQFDEVSEIASLITPVPGGVGPMTITMLMEQTYQAFKRSLES
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MIPO1_MOUSE
Sequence: MNSEQSIRELGNEVPSEDLELPGRKTSNFQVLQPCRDEGASAECSIVECGKNYEPVISHQVIPDLNKETSVAYLQKELEILRASNTKLQEKLAKEDKEKRRLKLKLELQEKAAEADIAERTAALVEEVYFAQRERDEAIMCRLQLALKERDEAIAHVKHMEMSLKMLENINPKENDMTLQELLDRINNADTGIAIQKNGAVIVDTIYKTTGCRKRITAEEMSAVLEERDAALSQCKQLHQRLLDLKKQNQTSTNNTKHPTAKNNQEHTLKYNLNIASIN
What are the official names of this protein?
Mirror-image polydactyly gene 1 protein homolog.
Protein: YOCN_BACSU
Sequence: MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGFGEENGDFTPLVVPISNVLDADLVDSNSAKNSVV
What are the official names of this protein?
Uncharacterized protein YocN.
Protein: KAD_NOCSJ
Sequence: MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVPDEVTNRMVRNRIDEPDAVGGFLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEIVGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYKQRDLVHEVDGIGEVDEVTARIFQALDVIPES
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_BRUMB
Sequence: MLTRKQHELLLFIHERLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLSPQKKFAPSVIEGSLGKVASVQPVRPAPAPQNSEAPATVSVPVMGRIAAGVPISAIQNQTHMLSLPPEMIGAGEHYALEVKGDSMIDAGIFDGDTVIIKRGDTANPGEIVVALVDEEEATLKRFRREGASIALEAANPAYETRIFGPDRVHVQGKLVGLIRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: HTPG_OLEA2
Sequence: MSKEHGAAAEKHEFRTEVRKLLHIITHSLYTNREIFLRELVSNASDALDKLRFAQTRGEAAPAADLDLNIAITVNEETRTLTVSDTGIGMTRQELIDNLGTIASSGSERFLKELAEKGEQASNIIGRFGVGFYAVFMVADSVTVTTRSALDASGAWRWTSDGLGSFELEEALDAPERGTRIDIRLKEDAGDFLKKDHLKDVIRRHSNFIPFPVSVEGEHVNTTPALWREPRFQVTEEQYKDFYTFLTFDTQAPMDTIHLSIDAPVQFTSLAFIPNFGNELFGYDRDKYGLDLYVRRVLISKEYKALIPEYLSFLKGVVDTEDLPLNISRETLQENALIAKIRQTLVKQVLAHLAKLAESDAEKYATFWRTHGRVFRMGYNDYINRDKFIPLLRFNSSALDDEKGLCSLDDYIGRAREGQKTVWYVSAPNREAARLNPHVEIFRRKGIEVLYLYEAADEFIMESLGKWNEFEFRSAEHADADALKDFDDVEKKDAPEALDEEGRKTLSSLLSHMKTLLGDKVEDVRESARLSDSPACLASKDGGMTASMEKLMRVMNKDESVPRKVLEINPDHPLTRNLLRLYRADADDRLLAQATEQLYESALLLEGYLRDPHALVGRVNSLLEQATGWYAEVRKL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_FLAJ1
Sequence: MHLNKLSLFNYKNFSEAGFDFDIKINCFVGKNGIGKTNVLDAIYHLAYGKSYFNPLAVQNIKHGEEFFVIDAELEKNDRTEQIVCSLKKGQKKVLKRNGKAYDKFSDHIGFIPLVIISPADRDLIVEGSETRRKFMDSVISQLDSTYLHQLIQYQKVIVQRNALLKYFALNHTFDNDTLSIYNEQLNEFGKSIFEKRKEFLEEFIPIFNVHHQAITGSEESVQLVYESHLFEKDLLTLLQENINKDRALHYTSSGIHKDDLSFEIDSHPIKKFGSQGQQKSFLIALKLAQFEFLKKQSGVKPILLFDDIFDKLDETRVAKIVEMVNSETFGQLFISDTHPERTEAIVKSTHQTYKIFNL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCP2_MOUSE
Sequence: MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSKQFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVSWFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKRRVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVPEEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNKYKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNPLELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAINSVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQNFNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRALPGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQNHPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPSDSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLSDTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVLNKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKEETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISETSAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRGSKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPKDWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRDENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKTSLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKAHEGNDA
What is the function of this protein?
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase.  Plays a role in the assembly of synaptonemal complexes (PubMed:16717126).  Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:16717126).  Required for insertion of SYCP3 into synaptonemal complexes (PubMed:16717126).  May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions.  Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
What are the official names of this protein?
Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein.
What is the protein family that this protein belongs to?
Belongs to the SYCP2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes.
Protein: A3673_ARTBC
Sequence: MKLASLLVGSLMLAVPALAFEQSAIQTLRDATTATGAYHSKFPHALSEGPEAAISNINSATARAADEAKTAMTGLTVQSQSLAGALKGVSWISPHVLVVLFMPKYGVLTMFVWQFFDAMTTLSHDATNPAVFCSKNIDRLGPSMGWNLRLPHATTLKRDCKDGEKLVADLAGSYKIAVDSLEQAQAMLESPQGKCKQ
What are the official names of this protein?
Uncharacterized secreted protein ARB_03673.
Protein: RK22_OENPA
Sequence: MKKKKTYGEVYALGQYISMSAPKARRVIDQIRGRSYEETLMLLALMPYRACDPILKLVNSAAANARHNMSFNEATLVISKAEVNEGTTVKKLKPRARGRSYPIRRPTCHIRIVLQDTSFDEFEEDFFSLKKDAWEKKIRTKI
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PIMT_SALTI
Sequence: MVSGRVQALLEQLRAQGIRDELVLNALAAVPREKFIDEAFEHKAWENIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWQARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMAQLDEGGILVLPVGDEQQFLKRVRRRGGEFIIDTVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BACAN
Sequence: MRKYEIMYIIRPGVEEEAQKALVERFAGVLTNNGAEIINTKEWGKRRLAYEINDLREGFYMILNVNANAEAINEFDRLAKINEDILRHIVVKEEEK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ITB6_SHEEP
Sequence: MGIELLCLFFLFLGRNDHVQGGCAMGGAETCEDCLLIGPQCAWCSQENFTHLSGVGERCDTPANLLAKGCQLTFIENPVSQVEILTNKPLSIGRQKNSSNIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTILEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGVLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNSGVPFPHQKKCSHMKVGDTASFNVTVSLPNCERRSRHVILKPVGLGDALEILVSPECSCDCQKEVEVNSSKCSNGNGSFQCGVCACNPGHVGHHCECGEDTLSTESCKEAPELPSCSGRGDCYCGQCVCHLSPYGNIYGPYCQCDNFSCVRHKGLLCGDNGDCDCGECVCRSGWTGEYCNCTTSTDPCVSEDGILCSGRGDCVCGKCICTNPGASGPACERCPTCSDPCNSKRNCIECYLSADGQAQEECVDKCKLAGATINEEEDFSKDSSVSCSLQGENECLITFLLTTDNEGKTVIHSIEKDCPKPPNIPMIMLGVSLAILLIGVALLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHKEKQKVDLSTDG
What is the function of this protein?
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity).  It recognizes the sequence R-G-D in its ligands (By similarity).  ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).  Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
What are the official names of this protein?
Integrin beta-6.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
Protein: TROPI_TALSN
Sequence: MASLPSQSCCYQGFRHSGAPKGTLSMVKDIEVYTSYPPDKSTEYGVLILTDIVGHRFSNAQIIADQFAENGYFVMMPDLFLGDAVPLNKPGEFDMGKWRSGAYHPQGKNHLPETVDPIVEVCLSEMRSKYQCKKIGAVGYCFGGKYVVRHLIPGKMDVGYTAHPSHIDESELKGIKGPLAIAAAAKDNIFPAEKRHVSEEILQEVGFPYQINLYSGVSHGFGVRGDMNAGEVRYAMRSAFVQAVEWFNEYMKEK
What is the function of this protein?
Hydrolase; part of the gene cluster that mediates the biosynthesis of the tropolone class of fungal maleic anhydrides (PubMed:22508998, PubMed:24863423).  The pathway begins with the synthesis of 3-methylorcinaldehyde by the non-reducing polyketide synthase (PKS) tropA (PubMed:22508998).  3-methylorcinaldehyde is the substrate for the FAD-dependent monooxygenase tropB to yield a dearomatized hydroxycyclohexadione (PubMed:22508998, PubMed:24863423).  The 2-oxoglutarate-dependent dioxygenase tropC then performs the oxidative ring expansion to provide the first tropolone metabolite stipitaldehyde (PubMed:22508998, PubMed:24863423).  Trop D converts stipitaldehyde into stipitacetal which is in turn converted to stipitalide by the short-chain dehydrogenase/reductase tropE (PubMed:24863423).  The next steps involve tropF, tropG, tropH, tropI and tropJ to form successive tropolone maleic anhydrides including stipitaldehydic, stipitatonic and stipitatic acids (PubMed:24863423).
What are the official names of this protein?
Hydrolase tropI, Tropolone synthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: UREE_RHOP2
Sequence: MIRASKVHGQYHWKEPAADTVVLDFDDRHRRRMAMTGTRGLSFLLDLEHATALRGGDALVLDDGRLIEVVAAPEPLLEIRGRDPQHLVRLAWHLGNRHLPTQIMAKALRIRRDHVIADMVRGLGGKAVEIEAPFDPEGGAYAPAHEGAAHHDHGGHEHRHHDHGHHDHADHEHDHKHDHGKHDHAGHDHAHDHHVHDEHCGHDHGHGHSHKHDHK
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMT2_TOBAC
Sequence: MEVISTNTNGSTIFKSGAIPMNGHHNGTSKHQNGHKNGTSEQQNGTISLDNGNELLGNSNCIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPTIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAEYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEIDFKNPVNPIDKETAQVKSKLAPLKFYNSDIHKAAFILPSFARSMIES
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (PubMed:10598105, PubMed:31276744, PubMed:34095742).  Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (PubMed:10598105).  Promotes leaves ripening (PubMed:34095742).
What are the official names of this protein?
Putrescine N-methyltransferase 2, NtPMT2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Putrescine methyltransferase family.
Protein: Y2318_SYNE7
Sequence: MNVNTARTSAVIVHPVPPAYADCYLVWQQSITTAAAQFDGYQGTDIYPPENDRDPNWIAVLHFQTPADLQGWLDSPQRAEILAQLPPELAGYSKTVLPQGFAPWFSQLLHKPPSWKMALTVLLALYPTVLLLNLLITPHLQGLGRAGAVLVGNAIGVALMQWGIMPRLTRLLKPWLSADSDRRFSVLGGAAIVSILLLLAHLFQRWFF
What are the official names of this protein?
Uncharacterized protein Synpcc7942_2318, ORF 2.
Protein: RLUA_VIBCH
Sequence: MAMTEYNPPKDPWIDVIYEDEHIIAANKPSGLLSVPGRPVEHYDSMWARLVDYCPDVKVVHRLDMSTSGLILFAKGKHMESALKKQFQYRLTHKIYYARVWGVMEQNEGEVNLPLCCDWPNRPKQKVCFEEGRDSLTRYQVVKREEKTTVVRLIPITGRSHQLRVHMQSLGHPIVGDDLYAPPEAVEFADRLQLHAAELCFYHPRSHWLRTLFVPCDFYPEAEEQILQHFDPERKLPDYKKLSQD
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluA, 23S rRNA pseudouridine(746) synthase, Ribosomal large subunit pseudouridine synthase A, rRNA pseudouridylate synthase A, rRNA-uridine isomerase A, tRNA pseudouridine(32) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: PG034_MONPV
Sequence: MIMRTDTNNILMRHLKNLTDDEFKCIIHRSSDFLYLSDRDYTSITKETLVSEIVEEYPDDCNKILAIIFLVLDKDIDVDIETKLTPTPKPAVRFAILDKMTADIKLTDLVRHYFRYIEQDIPLGPLFKKIDSYRIRAINNYSKELGLATEYFNKYGHLMFYTLPIPYNRFFCRNSIGFLAVLSPTIGYVKAFYKFIEYVSIDDRLKFKKELMSK
What are the official names of this protein?
Protein OPG034.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG034 family.
Protein: SYE_PYRFU
Sequence: MEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKIVEEVNTLSLEEQKKKLEEIYPEYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGAFHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELIFYDMIIEDLEWLGIKPDEIVYASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKMLNGEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDHELGVTHIFRGQEHSENETRQRYIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGKYLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDATVSWDNLAAINRKLVDPIANRYFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFIRLKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRKGLLEKNANVKEGEIVQFERFGFVRIDKIENDKVIAIYAHK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.