PharMolix/UniProtQA huggingface dataset:
Protein: SRGP3_HUMAN
Sequence: MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTM
What is the function of this protein?
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase.  May attenuate RAC1 signaling in neurons.
What are the official names of this protein?
SLIT-ROBO Rho GTPase-activating protein 3, srGAP3, Mental disorder-associated GAP, Rho GTPase-activating protein 14, WAVE-associated Rac GTPase-activating protein, WRP.
Protein: TOP6B_NATPD
Sequence: MTSYQSQLGDGGGGEPIAEELAESQQSISIAEFFEKNKQMLGFDSDAKALVTAVKEAVDNALDAAEEAGILPDIYVEIEDRGDYYRLTVEDNGPGITKEQIPKVFGKLLYGSRFHAREQTRGQQGIGISAAVLYSQLTSGKPAKITSKTDSHSSAQYFELTIDTDTNEPEIDHEREATWERPHGTRIELEMEGNMRARKQLHDYIKYTAVVNPHARVEFHEPEDSFKSERATEELPPETEEIRPHPHGVELGTLLKMLDATDSYSLSGFLQAEFTRVGNKTADGVIDSFRDRHFGREMAWSPPQPHEDVDIETAVSDAVANKSAEATAAFARAVADEVTDMAALSHAELSAVVASVADDIEAEHDETFGETVRENAVEAAWKSVTDDVSADCYALVDGATTTRKDDAAVEGLSRRLAEKFTDQEDARNRFRRSTLREFVDRAADATEEYDDATFGETARENVVEAVWERAVTVPDEPPTVTEVADNRDAAARLLEAMRSTDILSPPTDCLAPISEDLVKAGLKKEYDAEFYTSVTRDASVHGGDPFVVEVGIAHGGDIAVDGSVETLRFANRVPLVYQRGACATVDVLKGVNWRNYGLDQPGGSGMPSGPAVIMVHVASTSVPFTSESKDAVANIPEIEDELRLALQQAGRDLQSHLKKQRSLEKRRRKQDVIADILPDMAAKLSEVTDREPLDVEDSLARIMNNVLVERTVEESTVQLSVHNYGDTNVGPEVTDIVSQEPDGAESATVVEMDGEWFLKWSPTVGGGETATLEYEVDGDAEFDISVEGIEAEKLTVDA
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: HLDE_MARMS
Sequence: MNSSYLNFKDKHILVVGDVMLDRYWHGGTSRISPEAPVQVVKVSSIEDRPGGAANVALGLAKLGVSVTLVGVVGNDENADVLARCLEDAGVICRFVRSETLPTITKLRVMSRHQQLIRLDFEEREDSLSQNEALAKVVEECLPKSDAVIFSDYAKGCLADVQSLIKLSNAAKVPSFVDPKGNDFSIYQGATLVKPNLLEFETIVGKCSSTKELEEKAKALREQFGWKALLVTRGEDGLILLSDDKPPFSLATAAKEVFDVTGAGDTVVAVLTAVYVTSKRFIDAVEYANQAAGYVVGKLGTASISAERLDAIMFQRSHNTNFGVLSPKDLLEQIKLAQMNGEKIVFTNGCFDILHPGHIAYMKQAKALGDRLIVAVNTDASVKRLKGEKRPINNLIHRMSVLEGVGSIDWVTWFDEDTPKEIIEFLTPDVLVKGGDYTIETIVGADHVLAHGGEVKVLTFVDGYSTTSIIEKANL
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: METK_CHLAA
Sequence: MANTFMNSPRFYFTSESVSEGHPDKMCDQISDAILDAFLSHDPKARVAVETATTTGLIVVLGEVTYERGYIPIEEIVRRTVKEIGYTSAEYGFDADTCGVMVAIHGQSPDIAMGVDKALEAKIGAMADDVEAVGAGDQGMMFGFACDETPELMPASIALAHRLIRRLERVRKDGTLPYLRPDAKSQVTVEYSFGKPVRVDTVLISSQHAPDITQDQIRADLIEHVIKTEIPEAWLDSQTKIFINPTGRFVIGGPMGDSGLTGRKIIVDTYGGVARHGGGAFSGKDPSKVDRSAAYACRWVAKNIVAAGLARRVELQVSYAIGVARPLSLSVETFGTAAVPDEVILKAVNEVFDLRPGAIIRDLDLRRPIYRKTAAGGHFGRTDIDLPWERTNRVEELRRAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_CLOBH
Sequence: MSKDDVIEMQGTVLESLPNAMFEVELESGHKIIAHISGKLRMNFIRILPGDKVTVELSPYDLTRGRITWRAK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_FUSNN
Sequence: MVMKKKRIIAMILAGGQGTRLKELTEDLAKPAVAFGGKYRIIDFTLTNCSNSGIDTVGVLTQYEPRILNNHIGRGSPWDLDRMDGGVTVLQPHTRKNDEKGWYKGTANAIYQNIKFIEEYDPEYVLILSGDHIYKMNYDKMLQFHIQKDADATIGVFKVPLVDAPSFGIMNTKDDMSIYEFEEKPKEPKSDLASMGIYIFNWKLLKKYLDEDEKDPNSSNDFGKNIIPNMLNDGKKMFAYPFKGYWRDVGTIQSFWDAHMDLLSEDNELDLFDKSWRVNTRQGIYTPSYFTKESKIKNTLIDKGCIVEGEIEHSVIFSGVKIGKNSKIIDSIIMADTEIGDNVTIQKAIIANDVKIVDNIVIGDGKKIAVVGEKKIIDSQSLVK
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: PNP_GEOKA
Sequence: MEQEKRVFSIDVAGRPLIIETGELAKQANGAALVRYGDTVVLSTATASREAKNVDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAILVSRLIDRPIRPLFAEGFRNEVQVVSMVMSVDQDCAPEVAALIGSSVALTISDIPFEGPIAGVIVGRVDGQFVINPTVEQMEKSDLHLVVAGTKDAINMVEAGADEVPEEVILEAIMFGHEEVKRLIAFQEEIAAQVGKEKMEVVLYEPDPALEAEIRQLAEADIKRAVQVPEKLARDAAIEDVKAGVIAKYEAEEADEEKLKQVQEILHKLVKEEVRRLITVEKIRPDGRKVDEIRPLSSAVGVLPRTHGSGLFTRGQTQVLSVCTLGALGDVQILDGLDLEESKRFMHHYNFPPFSVGETGPMRGPGRREIGHGALGERALEPVVPSEREFPYTIRLVSEVLESNGSTSQASICASTLAMMDAGVPIKAPVAGIAMGLVKNDDHYTILTDIQGIEDHLGDMDFKVAGTRKGVTALQMDIKIKGLTREILEEALMQARKGRLEILDHMMQTLSEPRKELSKYAPKILIMHINPDKIREVIGPSGKQINKIIDETGVKIDIEQDGTIFISSVDEAANQKAKQIIEDIVREVEVGQVYLGKVKRIEKFGAFVELFNGKDGLVHISELAEGRVGKVEDVVSIGDEILVKVTEIDKQGRVNLSRKAVLRDARNIGGELPRESREKRGRRPERHRMKP
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCKD_BACSU
Sequence: MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQKKEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPHPHKFEKRH
What are the official names of this protein?
Uncharacterized protein YckD, ORF4.
Protein: NQOR_METBF
Sequence: MVKVNVIFHSIHGHTYKMAEAIAEGAREVEGAEVEIYQVPETLPYEVLEKMGAIETKNLFAHIPVVTRSMYEDVFAGADALIFGTPTRYGNMTAQMRTVFDGLGGLWSRDALVGKVGSVFTSSGTQHGGQESTILTTHVTLLHLGMIIVGLPYSETRQRRMDEITGGSPYGASTIAGAEENRQPSENELAMARYQGRHVTQIAKKLIG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ACCD_BACAH
Sequence: MLRDLFVKKKKYAAIPSEQVRKDVPDGVMTKCPKCKKIMYTKEVLKNLKVCVNCGYHHPMNAWERLDSILDEGSFREYDKEMVSLNPLEFPNYEEKLESDRKKTELNEAVVTGEGTIDDMLVVVAVMDSRFRMGSMGSVVGEKIARAVEKAYDLQVPFIIFTASGGARMQEGILSLMQMAKTSVALKKHSNAGGLFISVMTHPTTGGVSASFASIGDYNLAEPGALIGFAGRRVIEQTVREKLPEDFQTAEFLLEHGQLDAVVHRDDMRESLRKILEVHQGGEMAVWQS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1C_LACSA
Sequence: MIIDTTEVQAINSFSILESLKEVYGIIWMLIPIFTLVLGITIGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKENLLPSRGDTRLFSIGPSIAVISILLSYLVIPFSYHLVLADLSIGVFLWIAISSIAPVGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSSSTVDIVEAQSKYGFWGWNLWRQPIGFLVFLISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWNLSIPYIFVPEVFEITKRGRVFGTIIGIFITLAKTYLFLFIPIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTCSQLISL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KTHY_SHIF8
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: PSRP_ALBFT
Sequence: MSQRTVFFISDGTGITAETFGNAILAQFETNFRHVRLPFTDSVDKAHQAVREINHAGIVDGNKSIVFTTLVDMEVLKVITDNCHGMVLDMFSTFVHPLESELNLKSSHRIGRFTDASKSSAYQSRIEAINFSLAHDDGQSNTDLEHSDIILVGVSRSGKTPTSLYLAMQYGLKASNYPLIPDDFERQQLPPALKAHKSKLFGLTIQPERLSEIRNERRPNSKYASLENCRMEVSEAEAMMRRSGIRWLSTTTKSIEEISTTILQEIRPERLAY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: SLYX_SHEON
Sequence: MQGVQEQIEELQTKLAFQELTVEELNQEVIKLNQLVAHQQHQIQLLIGKLQAIEPSNMATQAEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RIMP_CLOBM
Sequence: MSKHNLIENLKKQIEPIVEGLNYELYHIEFVKEGKENYLRIYIDSENGASLEGCEKVSRAVSELLDDIDPIQESYYLEVSSPGIDRVLYTDKHLEKYKGYNIILNLYSPIDKKKKYEGELIDFNENEINIKVEENIVTIPREKISKTTLKGEL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQAN_BACSU
Sequence: MDCIKFTVYGEPVAQGRPRGSIRNGKVHMRDPAKSKYFKQYVALVASQHRPETIITGPVSMDVKVYRPMPKSVSNSKKKKEKAEKGLLRPTTKPDVDNYVKGVKDALNHLIYKDDSQVVDLKVSKFYSEEPRVEVMIREVSA
What are the official names of this protein?
Uncharacterized protein YqaN.
Protein: RK11_CYAM1
Sequence: MGKKVLAVVKLALPAGKATPAPPVGPALGQYGVNLVMFTKEYNAKTADQIGLIIPAQITIYEDKSYSFILKTPPASVLLKRAAQIEKGSNNGTIVASITQEQLQQIALTKLPDLNTKDVKKAMSIISGTAANMGIQIL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NPD_BACCR
Sequence: MIFVQQFEEVRSILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCKSGYDLQYMIDHEVPRCEKCNFILNPDVVLYGDTLPQYQNAIKRLYETDVLIVMGTSLKVQPVASFPQIAKREVGATTILVNEELTGQEYNFDFVFQNKIGEFVEGLSSMK
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPH_ANTSP
Sequence: MDSIISAASVIAAGLAVGLAAIGPGIGQGSAAANAVEGIARQPEVEGKIRGTLLLSLAFMESLTIYGLVVALSLLFANPYTG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PA2A1_BUNCE
Sequence: LVAVCVSLLGAANIPPQPLNLYQLMNMIQCANTRTWPSYTNYGCYCGKGGSGTPVDDLDRCCYTHDHCYNDAKNIDGCNPVTKTYSYTCTEPTITCNDSKDKCARFVCDCDRTAAICFAKAPYNTSNVMIRSTNSCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows anticoagulant and neurotoxic activities.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Acidic phospholipase A2 1, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYNP2_MOUSE
Sequence: MGTGDFICISMTGGAPWGFRLQGGKEEQQPLQVAKIRSQSKASGSGLREGDEVVSINGNPCADLTYPEVIKLMEGITDSLHLLVKRPSSGTSETLDSESETTNHQHLTHEGPMESTTLQIQQATETQSEDFFLAPVQTKVPLTEDQSNAWGYAECPKEEQAPPMLGSQEGHLVEEVILRQKAEAGQPGHVVELQLSLSKERHQCTSGPIVTLQGNDKSTSPDPDWSSQLERTVHINSIPAPEKADTSLTSSTSSGRELRVIQGRDPGGAGLPQVEVILDCSDRLKAEECRLQTGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEHGEDQRSGKDQSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREEEEEEDQEAGDKDEISEVAFLGTSESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGGMAGGGPDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLASVPQQNGFSGVSETAGAQRMFPMNRTAKPFLGSMNQPAAPFSPTRSVTSPISDFPAPPPYSAVSPPPEAFSRGVSSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGGDSGPEEDYLSLGAEACNFMQSSAKQKTPPPVAPKPAVKSPSSSQPVAPVSPVWSPGVAPAQRPAFSTSNPPNPPQVTAVSSIKIAQPAAPPARPASALNLAGPFKGPQAVVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTFQPPDSKDGLPQKSTVKVSSAPAMKQALPPRQANVGSPTNAQASSVYSVPAYTSQPNFFAAEATSPVSASPVPVSVPTSPKQESTSTSYFVAPRPKFSAKKSGVTVQVWKPSVVEE
What is the function of this protein?
Has an actin-binding and actin-bundling activity (PubMed:11673475).  Can induce the formation of F-actin networks.  At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines.  Involved in autophagosome formation.  May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes.  Involved in regulation of cell migration.  May be a tumor suppressor (By similarity).
What are the official names of this protein?
Synaptopodin-2, Myopodin.
What is the protein family that this protein belongs to?
Belongs to the synaptopodin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Cell junction, focal adhesion. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (PubMed:11673475, PubMed:15883195, PubMed:17923693).
Protein: GSH1_SALPC
Sequence: MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIQHMLTFMRDLHRYTARKLGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGVTEGEAAKEKISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEKTDCGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYARIGVEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQLRFLDLFMVWCVLADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCETAQFPLPKVGKDLFRDLKRVAQTLDSIHGGEEYQKVCDELVACFDNPELTFSARILRSMIDEGIGGTGKAFGEAYRNLLREEPLEILQEEEFIAERDASVRRQQEIEAADTEPFAAWLAKHA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: ROK1_NEUCR
Sequence: MDIFKVLSRGIKAQPKKNQPGAPQLLPSAGAKVNPQFFHDNVGGANAKRGKKRKRKGAQANNATESGDEDDDASDVDYFAPKPTPEELAAKKDAELKADEPKKQKPKLLEENECRQILKSHRLKFTVLAGRVPQDEAATEEKPPKKQKKQKEDRKKQEEEEKKKKKKDEDKKQIYPQPLNSFGELKYTYGIHPVLADNITRQGFRVPTEVQMGSLPLQLRPEMALEKATDVEDVKVEKGIDFLGVAPTGSGKTISFLIPAIDAIIKRRAEDYTPETDEHVLQAIVVAPTRELASQIVNEGRKLAIGTGVRVVLMKRTLRLVAESNEQEETEQEAKEEVQDSDSDSEAESEPEEVMKIDEEEEEEEESDSDAEKKTESRAKGDQKFKKERPITRVDILVTTPKILLNFLCGGEKEKGKPRIIKKTLPTVQSLILDEADVLLDPIFRKQTMGIWRACTHPNLGMTCWSATMASNIEALLTKHIDKRAKRTPEQTPKPLIRLVVGLKDTAVPNITHKLIYTATEPGKLLALRQLLHPVSSADSGPPLRPPFLVFTQTIERAQALHDELKYDIPLEAGGSARVAVLHSSLPDSVRSKIMARFRSGEVWVLITTDVLARGVDFAGVNGVVNYDVPVSAAAYVHRAGRTGRAGREGGVAVTFYTKDDIPFVKSVANVIAMSEKQAGKDIDEKDTVKAAQGSVQKWLLDALPKVAKEDKRKLKVRGVESRRTGGKATITTKSSWERRRENNRREAIEASKRRKREAQKAQKEGGAAPEKAEEEWTGLD
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase rok1, DEAD box RNA helicase 16.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL17_THEPA
Sequence: MVKYSREPSNLTRSAKAYGAYLRVHFKNTYETATAIKGMLVKDAKRYLNDVIERKRCVPFRKFRGGVGRCAQAKAFKHTQGRWPEKSCKFLLDLLKNLESNAEVKGLEQSKLRLEHVQVNRAPVGRRRSYRAHGRIIPFLSHPCHVELIAVEDEDHVPRHTSTEKRVVKLNKRELARMRLRTGKSLS
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SEMG2_HUMAN
Sequence: MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASRB_SALTY
Sequence: MSHCSCHDKPQHSLLPAAYRILSITRHTPLEWNFRVAVDFPAHWGQFVEVSLPRVGEAPISVSDYGDGWIDLLIRNVGKVTSALFTLKEGDNVWLRGCYGNGYPVDTLRHKPLLVVAGGTGVAPVKGLMRYFVENPQEIGQLDMILGYKNRDCVLYKEEMATWRGKHNLVLTLDEGEADDRYQIGRVTDRLADMTLSDIDTMQAIVVGPPIMITFTVKMLLQKGLKPEQIWVDYERRMACSVGKCGHCRMGEVYVCTDGPIFNYAVAQRFAD
What is the function of this protein?
This enzyme catalyzes the hydrogen sulfide production from sulfite.  It is strictly anaerobic.  It is regulated by electron acceptors rather than by cysteine.
What are the official names of this protein?
Anaerobic sulfite reductase subunit B.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPH6_MOUSE
Sequence: MASERKTKLSKNLLRMKFMQRGLDSETKKQLEEEERKMISDEHWYLDLPELKEKESFIVEEQSFSLCEDLLYGRMSFRGFNPEVEKLMLQMNSKNRAEAAEEDETVEVDVSDEEMARRYETLVGTIGKKFVKKRDRANYEEDENGTIKAIKPKKMFLKPQD
What is the function of this protein?
RNA-binding protein that associates with the RNA exosome complex.  Involved in the 3'-processing of the 7S pre-RNA to the mature 5. 8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.
What are the official names of this protein?
M-phase phosphoprotein 6.
What is the protein family that this protein belongs to?
Belongs to the MPP6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.
Protein: NDK_DESVH
Sequence: MVERTFSIIKPDAVERNLQGEVLAMIQGAGLKVVAMKMIHLTKAQAEGFYAVHRERPFFDSLTTYMCSGPVVCSVLEGENAISRYREIMGATNPANAAEGTIRKKYAVSLEANSVHGSDAPETAAFEISYFFNALEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.