PharMolix/UniProtQA huggingface dataset:
Protein: ASTRC_PONAB
Sequence: MEGAPTVRQVMNEGDSSLATELQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWISSSTYKDRNEEYRRQFTHLPDTERLIADYACALQRDILLQGRLYLSENWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIVTESEKFFFTSFGARDRSYLSIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMENLSLSIEDVRPRSPGRSSLDDSGERDEKLSKSISFTSESISRVSETESFDGNSSKGGLGKEESQNEKQTKKSLLPTLEKKLTRVPSKSLDLNKNEYLSLEKSSTSDSVDEENVPEKDLHGRLFINRIFHISADRMFELLFTSSRFMQKFASSRNIIDVVSTPWTAELGGDQLRTMTYTIVLNSPLTGKCTAATEKQTLYKESREARFYMVDSEVLTHDVPYHDYFYTVDRYCIIRSSKQKCRLRVSTDLKYRKQPWGLVKSLIEKNSWGSLEDYFKHLESDLLIEESILNQAIEDPGKLTGLRRRRRTFNRTAETVPKLSSQHSSGDVGLGTKADITGKKKEMENYNITLIVVMSIFVLLLVLLNVTLFLKLSKIEHAAQSFYRLRLQEEKSLNLASDVVSRAETIQNNKDQAHRLKGVLRDSIVMLEQLKSSLIMLQKTFDLLNKNKTGMAVES
What is the function of this protein?
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity).  Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity).  Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity).  In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity).  At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).
What are the official names of this protein?
Protein Aster-C, GRAM domain-containing protein 1C.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single- pass membrane protein. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS).
Protein: MTGA_ECOUT
Sequence: MSKSRLTVFSFVRRFLLRLMVVLAIFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDWVSMDQISPWMGLAVIAAEDQKFPEHWGFDVASIEQALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSAPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RR3_AMBTC
Sequence: MGQKINPLGFRLGTTQSHRSLWFAQPKDYSRNLQEDEKIRDCIKNYVQKHMRISSGFQGIARLGIQKRIDLIQVTIYIGSSNLLIEGPTRGIEELRTDVQKKLNSMNRRLNITITRIARPYEQPNILAEYIALQLKNRVSFRKAMKKAIELAEQANTKGIRVQIAGRLNGKEIARVEWIREGRVPLHTIRAKIDYCSYMVQTIYGVLGIKIWIFVDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FOXG1_PIPRU
Sequence: MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHPPPPAPQPPPPPQQQPPPPQAPQPPQARGAPAADDDKGPQQLLLPPPPPPAAALDGAKADGLGGKGEPGGGGAGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH
What is the function of this protein?
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
What are the official names of this protein?
Forkhead box protein G1, FoxG1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRAAH_MYCSJ
Sequence: MTIEPRATADLVDDIGPDVRSCDLQLRQFGGRPEFAGRVTTVRCFQDNALLKSVLSEPGDGGVLVIDGDGSLHTALVGDVIAALGRDNGWSGLIINGAVRDASTLRTLDIGIKALGTNPRKSTKTGAGERDVPVEFGGVTFTPGDVAYSDDDGIVIVTP
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: DAPB_CHLMU
Sequence: MKKSVGLIGNTGRMGGLLTEALRSHPRCLLGKGFSRRSQTLLKEVVLENDILIDFSAPEVTETLMDILLVTPKPVIIGTTGFSDNSVIRDKLSLLSEYVPVIFSPNMSLGAYVQRRLTACAAKLFDASYDVRILETHHRTKVDAISGTALSLAEAICSAKKDHFGDEQEPCIEMFGSRVGNIFGEHEVSFVGKNERFVIRHEAFSRQTFSDGVLIILRKIMEERLPAGYYTSDVLYESLFQEVVFD
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTU1_MALGO
Sequence: MPRECELCGTERAVLRRPKTGDLVCRACFFHVFETEVHQTIVEAQLFRRGDRVAIGASGGKDSTVLAYVMKTLNERYDYGLNLFLLSIDEGITGYRDDSLETVKRNQEQYGIPLKVLGYKELYGWSMDDIVASIGRKNNCTFCGVFRRQALDRGAASLGVDHIVTGHNADDMAETVLMNVLRGDIARLERCTDIITKGPDGVDGDEDDDETEGCGAGRSGFGGSGIRRSKPFKYAYEKEIVMYAYFKQLDYFSTECIYSPNAYRGYARAFLKDLESIRPSSIIDIIHSGENLHVAGQVKRAVQRTCTRCGYISSNELCKACVLLEGLNRGAPALGVRSDKSRAVREARLDGTSDIGRTIPRWEGVQRSSATAW
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_MYCSK
Sequence: MARLFGTDGVRGVANRDLTAELALALGSAAARRLSTAGHARRRVAVVGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTSAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDATEDRIAELVQQGPGERPVGAGIGRVVDAPDALDRYLRHVGKAVTTRLDALTVVVDCAHGAASAAAPLAYRAAGANVLTINADPNGLNINDGCGSTHMETLQAAVVSYGADLGLAHDGDADRCLAVDANGRVIDGDAIMVVLALAMRESGELASDTLVATVMSNLGLHLAMRDAGIEVRTTSVGDRYVLEELRAGSYSLGGEQSGHIVMPSMGTTGDGILTGLRLMSRMAQTRKSLAALAEPMHTLPQVLINVQVADKTTVAQAPSVQSAVAEAEAALGDTGRILLRPSGTEQVVRVMVEAADEDTARQLAVRVAESVSEQR
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: NMNA2_HUMAN
Sequence: MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG
What is the function of this protein?
Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity).  Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).  Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747).  Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747).  Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747).  Also catalyzes the reverse reaction, i. e.  the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747).  For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747).  Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747).  Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed:34314702).
What are the official names of this protein?
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon. Note=Delivered to axons with Golgi- derived cytoplasmic vesicles.
Protein: MDTH_PHOLL
Sequence: MSLVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIHFVEQLGWAALVVGFALGLRQFVQQGLGIFGGAIADRFGAKPMIVTGMLLRALGFAFIALATEPWILWLACILSALGGTLFDPPRTALVIKLTRPHERGRFFSLLLMQDSAGAVIGALIGSWLLQYDFQFVCWTGAGVFVLAAIWNALFLPAYRISTTRTPIWEGMERVIKDRRFFTYVLTLTGYFMLSVQVMLMFPIIVNEIAGTPAAVKWMYAIEATLSLTLLYPIARWSEKRFRLEQRLMAGLFLMSLSMFPVGLIGEINTLFGLICLFYLGTVTAEPARETLSASLADPRARGSYMGFSRLGLALGGALGYTGGGWLYDTGHALNIPQLPWFLLGIIGLITLYALHRQFNQRKIESAMLSGN
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF3_STRP4
Sequence: MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNXLDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTXKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILGIASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDDIELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLETFLKFAPEPHGHKKTDGEIVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNVTQFMAESRENVINAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSAKNVMKQKSFHKGIEQLVQEGAIQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAEVVMNPMGKKTVRWIKPEDLDERMSSSRNXLAKDRFDQPVFLFENDFALRWFADKYPDVELEEKM
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QRIC2_HUMAN
Sequence: MKDAAEELSFARVLLQRVDELEKLFKDREQFLELVSRKLSLVPGAEEVTMVTWEELEQAITDGWRASQAGSETLMGFSKHGGFTSLTSPEGTLSGDSTKQPSIEQALDSASGLGPDRTASGSGGTAHPSDGVSSREQSKVPSGTGRQQQPRARDEAGVPRLHQSSTFQFKSDSDRHRSREKLTSTQPRRNARPGPVQQDLPLARDQPSSVPASQSQVHLRPDRRGLEPTGMNQPGLVPASTYPHGVVPLSMGQLGVPPPEMDDRELIPFVVDEQRMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEPLGMDQRGCVISGMGQQGLVPPGIDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPISADQQGFVQPSLEATGFIQPGTEQHDLIQSGRFQRALVQRGAYQPGLVQPGADQRGLVRPGMDQSGLAQPGADQRGLVWPGMDQSGLAQPGRDQHGLIQPGTGQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQRALVQPGAYQPGLVQPGADQIDVVQPGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQRGLAQPRADHQRGLVPPGADQRGLVQPGADQHGLVQPGVDQHGLAQPGEVQRSLVQPGIVQRGLVQPGAVQRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQPGADQPGLVQPGAGQLGMVQPGIGQQGMVQPQADPHGLVQPGAYPLGLVQPGAYLHDLSQSGTYPRGLVQPGMDQYGLRQPGAYQPGLIAPGTKLRGSSTFQADSTGFISVRPYQHGMVPPGREQYGQVSPLLASQGLASPGIDRRSLVPPETYQQGLMHPGTDQHSPIPLSTGLGSTHPDQQHVASPGPGEHDQVYPDAAQHGHAFSLFDSHDSMYPGYRGPGYLSADQHGQEGLDPNRTRASDRHGIPAQKAPGQDVTLFRSPDSVDRVLSEGSEVSSEVLSERRNSLRRMSSSFPTAVETFHLMGELSSLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQMVKRTIPPELQEQLKTVKTLAKEVWQEKAKVERLQRILEGEGNQEAGKELKAGELRLQLGVLRVTVADIEKELAELRESQDRGKAAMENSVSEASLYLQDQLDKLRMIIESMLTSSSTLLSMSMAPHKAHTLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKKAKLQRQDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIAMLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDATTEQLNHMMQELVAKMSGQEQDWQKMLDRLLTEMDNKLDRLELDPVKQLLEDRWKSLRQQLRERPPLYQADEAAAMRRQLLAHFHCLSCDRPLETPVTGHAIPVTPAGPGLPGHHSIRPYTVFELEQVRQHSRNLKLGSAFPRGDLAQMEQSVGRLRSMHSKMLMNIEKVQIHFGGSTKASSQIIRELLHAQCLGSPCYKRVTDMADYTYSTVPRRCGGSHTLTYPYHRSRPQHLPRGLYPTEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILRKDSSGTSKRKSQQPRPHVHRPPSLSSNGQLPSRPQSAQISAGNTSER
What is the function of this protein?
Has an essential role in the formation of sperm flagella and flagellar structure maintainance.  It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.
What are the official names of this protein?
Glutamine-rich protein 2.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa.
Protein: RS16_CAMJJ
Sequence: MTVIRLTRMGRTKRPFYRIVVTDSRKRRDGGWIESIGYYNPMVEPEVIKVDAERLAYWKSVGAKLSDKVASITSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SYC_BAUCH
Sequence: MLAIFNTLTNKKEIFKPIHIGKVALYVCGVTAYDLCHIGHVRTFVTFDVVIRYLRYCGYEVNYIRNITDIEDKIIRKAANNGESCQQLTDRMIAEMHHDLDLLNILRPDKEPRATQHIKEIIQLTRQLIDKEHAYIASNGDVMFAIESANNYGILSSQNLNQLQIGQRVKITTVKRNPMDFVLWKMSKHGEPTWSSPWGNGRPGWHIECSAMSIKYLGKHFDIHGGGSDLIFPHHENEIAQSTCMENNPYVNFWMHSGMVTICNEKMSKSLSNFFTVRDVLKYYDAETVRYFLISSHYRKPLNYSEKSLQLARTALKSLYIALRNTKKEVIPSGGEYFIEQFMMAMNNDFNTPAAHAVLFQLAHEVNRLKTKNIKSAQGMAATLRYLANILGLLEQDPEVFLQKQKIVTDLNIALIEELVKQRNNIRKKHQWVQADKVREKLAAMGIVLEDTPQGTIWRRSF
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPCS_METJA
Sequence: MGLNITGLIPKHMENRGKLTLKENLKIIENILEQRKAPENGIDEEHIKLLLRLLSFMDTDKDPNVVQIGEREARVYTKLQRDGVFDFCHGVGRSGNLIDPQPKAPGASVMYKLTNKLLESFLKALGLKVNAIATPVATGMSLALCLSAARKKYNSNVVIYPYAAHKSPIKATSFIGMRMRLVETVLDGDIVKVEVSDIEDAIRKEINENNNPVVLSTLTFFPPRKSDDIKEIAKICQDYDIPHIINGAYAIQNFYYIEKLKKALKYRIDAVVSSSDKNLFTPIGGGIIYTKDESFLKEISLTYPGRASANPIVNILISLLAIGTKDYLNLMKEQKECKKLLNELLEDLAKKKGEKVLNVENPISSCITTKKDPLDVAGKLYNLRVTGPRGVRRNDKFGTCYLKEYPYDYIVVNSAIGVKKEDIYKVIEKLDEVL
What is the function of this protein?
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
O-phosphoseryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS.
What is the protein family that this protein belongs to?
Belongs to the SepSecS family.
Protein: O1086_MOUSE
Sequence: MENITEVTEFILMGFTDNADLEILSFFLFLAIYLFTLMGNLGLITLVIGDSRLHNPMYYFLSVLSSVDACYSTVITPQMVVDFVSEKKVISFIGCATQMFLAVTFGTTECFLLAAMAYDRYVAIHNPLMYVVSMSPRVYVPLIIASYAGGILHAVIHTVATFRLSFCGSNKISHIFCDIPPLLAISCSDTHFNQLLLFYCAGFIEVVTILIVLLSYGFILSVILKTRSTEGKRKVFSTCGSHLMAVSTFHGTVLFMYVRPSDSYALEHDMMVSIFYSIVIPMLNPLIYSLRNKDVKEAIKKVFGKRILCG
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 1086, Olfactory receptor 179-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: L_CHAV
Sequence: MDLNPVDDAAELSEENFFSGKLSKECRIRGLNSVDYNLNSPLVSDDLTYLLDKFKGKPVPIRWKMKKWDSILDQLRKHDLEYLRPSDLHQWFAEWMLYSKHGSKQGEDFLKTVDEEASDTFEVVRSFIRGWTGGEINFVRKSGKHMGYCAELCQKFLDLHKLTLLGNAATDNELLQLSKTFGDDKIYKKRLIKLPSLGRVIFDSGFFIVLDQRVLMDRNFMLMMKDVIIGRMQTVLSMISRCDDKFSSKDIDFLLKVYSTGDKIIRKLGNDGYELIKTVEPMCNLRLSDLARRFRPLIPPFPHFRRHIESTVDELSAKTPLIRELFSLIDTSPNVDSTLVVYGSFRHWGHPFINYFEGLEKLHKQVTMEKEIDTNYSEALASDLARIVLTKEFNEKKQWAVDYHRVPTNHPFKNHIRDNTWPTAAVIQDFGDHWHELPLIQCFDIPDLIDPSIIYSDKSHSMNRSEVLNHVRTKPHTPIPSKKVLESMIDKPATNWLEFLEEIDKNGLSDEDLVIGLKGKERELKIAGRFFSLMSWKLREYFVVTEYLIKTHFVPLFHGLTMADDMTAVIKKMLESSSGQGLTNYESVCIANHIDYEKWNNHQRKLSNGPVFKVMGQFLGYPNLIYRTHEFFEKSLIYYNERPDLMKVKNGILENSTHQRVCWNGQAGGLEGLRQKGWSILNLLVIQREAKIRNTAVKVLAQGDNQVICTQYKTKQYRNDIELRQALNQMAANNDVIMKAIESGTNKLGLLINQDETMQSADYLNYGKVPIFRGVIRGLETKRWSRVTCVTNDQLPTCANLMSSVSTNALTVAHFDVHPLNAMIQFNFFGNFARLLLIMHDPAIRQSLNQLKGPNINVHSYGFKVAMLYLDPSIGGVCGTALSRFLIRSFPDPVTESLSFWKLIHHSTSDIRLKNLSEQFGNPKIAVFRESHIEKLLEDPTSLNISMGMSAANLLKTEIKKNLLQKKSSIGNQIVKDAVYYIHSEDEKLRTFLWSITPLFPRFLSEFKAGTFMGVASSIVSLFQNSRTIRNVFRDYMSQTIDDLIVKSELTSLEHLSNYTDRKGSGGIWGCSAEQADKLRRMSWKRPVLGTTVPHPLEMHGRGTLKSPLSKCCKESRMDYISVHIPEGLNKVLDGRGSLPAYLGSKTSESTSILQPWEKESKIPIIRRATRLRDAIHWFVDPDSNLARSILNNIESLTGEKWEGALKGYKRTGSALHRFSTSRVSHGGFSSQSPACLTRMMATTDTMRDYAQLNYDFMFQASLLYSQMTSSVILMGTTVSNTIHFHVTCRKCIREITEPMLESPREYRGKDVHLVLAKWKNSSNGWGETLQLLKPVEGDWDTIPPVEKSYHVGRILGFLYGDLKSQNSSRADDSSIFPLSIQMRLRGRGFLRGILDGLVRASACQVIHRRSVALLSKPANAIYGGLIYLIDKISASTSFTTLCRDGPIREELSSIPHKIPTSYPTSNSDMGLHIRNYLKFQCKTVELGKYQSDIKDLWLFSDVMTSNIAGPFALSTKILKCLYKPALSQKDRNNIRKISNFSKMMRSQLSWDPTSSEFITSQILVCNEEIRHACKFGIPKLSLKFDDPVWGPEDYGLIWSIPVDYSSQSVPKNLKPCPRIQNPSISGFRLGQLPTGAHYKLRSILRKKNIHYRDALCGGDGSGGMTAAVLRYNLKARAIFNSILDFDGSTMKGASPDPPSALETVVNGRTRCVNAESCWENPSDLSEQRTWDYFKFLKTHHGLKIDLIVLDMEVRDFAISASIEKCVRHNVSSILEEDGVLIYKTYGSTIAAESSNAVVNIGVLFESVELIQTEYSSTSTSEVYMYCRKIKKFVDAPHPDWISLDYYWSKLLCFRSYKEEFFRSYEVSRKESLKGIPNSFIPDPLVNLETLLQIAGVPSGISHQLAIDIKESQLTQITAAMVLCGMIANYTLDVTKKRDSYNPPSDGRLIRMSAALVGISFWISVKYYDKELNFELEQILSRSFPIRWMLSHNYLFWTTKKGFRNAKDVRLSGNMANIGNWIRCMELLHLPPGSLSKDEVTTTCGKYIRNLKYSVILQQTGIIDLWKSRVASDDRSLMEVKTEFIESEHWVD
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviridae protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: APGM_PYRIL
Sequence: MPSVFWILFDGGGDRPVGGRTPFHTAFKPTIDYLTSLGSCGILDPIAPGVRPGSDTAHLALFGYDPYKYYTGRGAFEALGAGLELKPGDVAFRTNLATIDDNGMVLDRRAGRYITPEEVEAVENLMANIAEDIKRKYGVEIIYKSTVEHRGVLVLRGSVSHKVSDTDPHKVGAKLLESRPLENSKEAVLTAEVINEVTKRFSEVAKDLEINRKRRLEGRLPINAILLRGGGYMPQIEPVRERYNIKAAAIAGVALIRGVARAVGMDVYTARGLGGTKDDMFDEAVRLAVELMGRYDLVFLHVKGTDSASHDGDFKGKVSVIERLDKALTPYLDKLLNNYVVITSDHATPISIKEHTGESVPILLYGPDVVTDDVSKFSELTCWRGALGRIRGIDVMPILGSYLALTEKFGE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: E6_GOSHI
Sequence: MASSPKLFSMSILFLFALFSMQIHAREYFSKFPRVNINEKETTTREQKHETFVPQTTQKPEEQEPRFIPETQNGYGLYGHESGSSRPSFTTKETYEPYVTPVRFHPDEPYNSIPESSNNKDTYYYNKNAYESTKQQNLGEAIFTEKGWSTKENQNNNYYNGNNGYNNGEKQGMSDTRYLENGKYYYDVKSENNYYPNRFDNSRGVASRNEFNENRYNNMGRYHQNQEEFEESEEEFEP
What are the official names of this protein?
Protein E6.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: MSCL_PARDP
Sequence: MFKEFKEFIARGNVIDLAVGIIIGAAFTAIVNSLVADLINPIIGLLTGGTDFSGHYLVLKGEVPPGASLQVARDSGASVFAYGAFLSAVINFLIIAWAVFLLVKAVNRVQSAASRQKEAEAEAAAGPTQEELLTEIRDELRARRT
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_BACFR
Sequence: MPTIQQLVRKGREVLVEKSKSPALDSCPQRRGVCVRVYTTTPKKPNSAMRKVARVRLTNQKEVNSYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGTLDTAGVAGRTQRRSKYGAKRPKPGQAAPAKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: M2_I89A2
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQNAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).