PharMolix/UniProtQA huggingface dataset:
Protein: DAPD_PARXL
Sequence: MSQQLQQIIDTAWENRAELSPKAAPADVREAVAHAIEQLDKGLLRVAEKKDGDWVVNQWLKKAVLLSFRLEDNAPMPAGGYSQFYDKVPSKFASYTAEDFAAGGFRVVPPAIARRGSFIAKNVVLMPSYTNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPVIIEDNCFIGARSEVVEGVIVEENSVISMGVYLGQSTKIYDRETGEVTYGRIPAGSVVVAGNLPSKDGTHSLYCAVIVKKVDARTRAKVGLNELLRGD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_LEGPH
Sequence: MSAYFRRKKMCRFSAEGGNEIDYKDINLLKNYITETGKIVPSRITGTQTRFQRQLAKAIKHARFIGLLPYCDSHR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RPOC2_SYNR3
Sequence: MTSSSKPARKTSKSKSKASKAAEAPAAPSNELSREAPTFQNKVIDKKALRSLVAWSYKHHGTAATSALADDLKDLGFRFATQAAVSISVDDLRVPGDKSTLLQEAEDQITATEERYRLGEITEVERHTKVIDTWTETNERLVQSVRRNFDENDPLNSVWMMANSGARGNMSQVRQLVGMRGLMANPQGEIIDLPIRTNFREGLTVTEYVISSYGARKGLVDTALRTADSGYLTRRLVDVAQDVIVREDDCGTTRSIKVAADDNGKYKSRLVGRLLAEDVVDGAGEVIATRNTEVDPPLSARIEAAGIAQVQVRSPLTCEAARSVCRKCYGWALAHNELVDLGEAVGIIAAQSIGEPGTQLTMRTFHTGGVSTAETGVVRSVVEGSVEFSAKAKVRPHRTPHGVEAQLAETDFSLTVKPSGKGKTQKLDVTAGSILFVNAGGSVPNDTILAQISSGSAVKKSVEKATKDVVCDLAGQVRYEDVIQPKEVPDRQGNITLKAQRLGRLWVFSGDVYNLPPNAMPVVQGGANVKTGEVLAESRQVSEFGGAVRLRESQGDSREVEIVTSSLTLKDCKLVATTTHSGQIWHLESKDNTRYRLNTEPGTKIANGEVIAELADDRFRTQTGGLVKFAPGLAIKKARSAKNGFEVSKGGTLLWIPQETHEINKDISLLMIEDGQWIEAGTEVVKDIFSQTAGIVTVTQKNDILREIIVRSGQLHLVSDSKVLARYTDGGGKMVNPGEEIAPGLKAEAMHMVEAVDTPEGGALLLRPVEEYAIPNEAHMPELGSVKQANGPSMGLKAVQRLAFKDGELVKSVEGVELLRTQLLLETFDTTPQMTVDVESAQDKRAKTIQRLQLTILETHLVRRDTLSDASHGSTHTEVKVADGDNIKRGDVVATVQILCKDDGVAQLPDRKDDEPIRRLIVERPSDTITVDLGGSKLSLKAGQRVVEGDDLGGGLTCPHSGQVEEVKGSSLTLRVGRPYMVSPDSILHVRDGDLVLRGDTLAQLVFERAKTGDIVQGLPRIEELLEARRPRESAVLCRKAGTIKVEQPEGEDNPTVSVNEGEELHTEYPILLGRTVMVSDGQEVKAGDLLTDGPINPHELLEVIFEDLRGPLPTMDAANQAIGRLQTALVQEVQNVYKSQGVTIDDKHLEVIVRQMTSKVRIEDAGDTTLLPGELIELRQVDQVNQAMAITGGAPAEFTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIEGKSDWLRGLKENVIIGRLIPAGTGFSGFDEQLKAEALPHPDILGEENAGYRRATNLRPDYTVEMPLPQSNTAVLDDPSDTELEATRSRHGIEDRTNLAAFARPAAGEELAEEHVPDPGALEGLQEEGLLSQDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: TBX6_XENLA
Sequence: MYHSELFQQYGTSYTMRPPHALAPTYPSAGGHHDSYRYSELDVPSQRFDGLFPALEPSQRILGAPPLTPLSLPPGPALGFGQVQPPCETPQLPGNVKMKLENKELWKQFHSIGTEMIITKSGRRMFPQCKVSVSGLEADGKYLLLADLLPVDNSRYKWQEDHWEASGRAEPRLPERVYIHPDSPAPGSHWMKQPISFHKIKLTNNTLDQMGHIILHSMHKYQPRFHIVRAQDVFSRRWGGCSSFTFPETLFLTVTAYQNEKITQLKIQTNPFAKGFREDGMKSKRDRSIRGKRKVISVEQEQEEEEQFQPEGECKRPPLYSGPCDSTLSEELDIGRSLGIPSPNCSFHPITPPTQTPPSTETPNPSLPANQEQGAPLQMSSQTPGTFLQTYPEPPRGASSLYSCSPTDAAQNQTLRPSAQRLPPGYQESPHISHSQGELKIYGTEMGPPGNFNPPSCAVTPSVRLSDEPMGRGFSMNFPHFLPNNKIGLQISGAQLQRMYNGGGWM
What is the function of this protein?
Transcriptional activator.  Plays a role in ventral mesoderm specification and acts together with nog during muscle differentiation.  Mediates posterior pattern formation of the embryo, including specification of posterior mesoderm, via activation of the Wnt and Fgf signaling pathways.
What are the official names of this protein?
T-box transcription factor TBX6, T-box protein 6, XTbx6.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOC2_COXBU
Sequence: MMVNSLKKRIQRSFNKAFDTYDDHASIQREICKQLLKPLKEMRIQTKIIADFACGTGISTKAVADSFPYQNLYAIDFCEKLLIQAKSKLKESNVEFILADFETNVFLCNSLDLIFCNMGFQWALDLKQTFFSLFSQLKAFGVLAFSVPLLGTFCELRNDCRNPFLTLQSIVQLLKAVGFELLTADEKIFTDSFESPLDAIRSIKSIGANCLLYPKRNKGLSPMPIEKNNTDTTLTYHIGFFIAKKIIQ
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase 2, Malonyl-ACP O-methyltransferase 2, Biotin synthesis protein BioC 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: WBNI_ECOLX
Sequence: MVINIFYICTGEYKRFFDKFYLSCEDKFIPEFGKKYYVFTDSDRIYFSKYLNVEVINVEKNCWPLNTLLRFSYFLKVIDKLQTNSYTFFFNANAVIVKEIPFSTFMESDLIGVIHPGYKNRISILYPWERRKNATCYLGYLKKGIYYQGCFNGGKTASFKRLIQICNMMTMADLKKNLIAKVHDESYLNYYYYYNKPLLLSELYSWPEKYGENKDAKIIMRDKERESWYGNIKK
What is the function of this protein?
Involved in the assembly of the O-repeating unit during O-antigen biosynthesis.
What are the official names of this protein?
O-antigen biosynthesis glycosyltransferase WbnI, UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
Protein: RNC_ALBFT
Sequence: MNNGLMALQARLQHEFSNPGLLTRALTHRSFSLDHNERLEFLGDSVLGLAVADLLYERLSTLPEGDLSRVRANLVKQDTLHHLALGLGLPEVIRLGEGEARSGGHKRPSILADALEAVIGAVYLDAGFAVAQGLVRRLFQAVEIKSDMEAIGKDPKTELQEWLQGRKMNLPLYRVVATLGAAHKQTFDVECEIVELNFLERGIGGSRRAGEQAAAAAMLQTLKAKAAQ
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA1_XANOR
Sequence: MPPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPNQKRGIRVPGGAGRDALLNLPVLGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKRLERGTERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: HISZ_SYNP2
Sequence: MIHQPPAGARDLLPLEVAQKAWINDNLQRVFQQWGYQRIVTSTLEWLETLTAGGAVDRTKVIQLQTAESQALGLRPELTASIARAAVTRMAENTFPQRLCYRANVFRHPPRGSHGKQMEFYQAGVELLFAAGIVADAEILLLLADSLDALGLEDWQLILGEAALGRSLLDPFPEPVRETVRHCVANLDRVGLQELPLDEDLKAYALDIFDLRGEPETILARVSQFDLGPEAQEIVANLKALFALLAGSTQKQLPIILDLTLIQTFDYYTGIVFEVVNFANHQSYILGQGGRYDQLLGLYHPQRENHPGIGFCLNIEELHTCLLTSPQLPKQLAGSAWLVIATEPNAQQQVFHYAQTLRQGDEMVRVEVELGGRSPAEIYAYARSSHITHLAWIDPSGEPKLETL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_VIBA3
Sequence: MTNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAVHSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKLDDGQYDAIVLAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLEGGCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGAREILTKLYADQE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CARB_RHIME
Sequence: MPKRQDIKSILIIGAGPIVIGQACEFDYSGTQACKALKEEGYRVILVNSNPATIMTDPGLADATYVEPITPEVVAKIIAKERPDALLPTMGGQTALNTALSLRRMGVLDRYNVEMIGAKPEAIDKAEDRALFREAMAHIGLETPKSRLANATDIKDHDRKSHEAERSALKAKLSGDELDKALDELENQWNLGEGDRKQRYVNHAMAIAAQALDDVGLPAIIRPSFTLGGTGGGIAYNRSEFFEIVGSGLDASPTTEVLIEESVLGWKEYEMEVVRDKADNCIIICSIENIDPMGVHTGDSITVAPALTLTDKEYQIMRNASIAVLREIGVETGGSNVQFAVNPENGRLVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELENDITGGATPASFEPSIDYVVTKIPRFAFEKFPGAEPTLTTAMKSVGEVMAIGRTFAESLQKALRGLETGLTGLDEIEVPDFDDNGDGRNAIRAALGTPTPDRLRMVAQALRLGMSEAEVHEACKIDPWFIAQFKAIVDMEARIREHGLPADAENLRMLKAMGFSDARLATLTGKRPKEVAELRNALNVRPVYKRIDTCAAEFASPTAYMYSTYETPFVGAARSEAQVSDRKKVVILGGGPNRIGQGIEFDYCCCHAAFALKDAGYEAIMINCNPETVSTDYDTSDRLYFEPLTAEDVIEIMRAEQENGTLHGVIVQFGGQTPLKLAEALEKNGIPILGTAPDAIDLAEDRDRFQKLLMKLDLNQPNNGIAYSVEQARLVAGEIGFPLVVRPSYVLGGRAMQIIHSESMLQSYLLDTVPGLVPEDIKQRYPNDKTGQINTLLGKNPLLFDSYLTNAIEVDVDCLCDGKDVFVSGIMEHIEEAGIHSGDSACSLPVHSLGTDMVDELERQTGALARALNVGGLMNVQFAIKDGTIYVLEVNPRASRTVPFVAKTIGAPIAKIAARVMAGEMLDEAIAAYGKKPNPRNLKHIAVKEAVFPFARFPGVDTLLGPEMRSTGEVIGLDTDYALAFAKSQLGAGVDLPRDGTVFVSVRDEDKERVLPAIRILSDIGFKVMATGGTARFLGEQGIVATKINKVLEGRPHVEDAIRNRQVQLVINTTDGNKAISDSKSLRRATLMQKVPYYTTMAGAEAAALAIKALKAGNLEVRPLQSYFET
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: DNAJ_LEGPA
Sequence: MEQRDYYELLEVSRNASDAEIKKAYRRLAMKYHPDRNPGDTSAEEKFKEIQKAYNILSDKQKRAAYDQFGHAGVDPSMGGGPGGFGGFGGFGDVFEDIFENIFSGGRGHGRQSRGQRGADLQFNVQLTLEEAAIGKEVEITVPRHGTCTVCEGSGAKKGTSPKTCETCQGMGQVRIQQGFFSIQQTCPTCHGEGKIISDPCASCHGQGRVRESKKINVKIPAGVDNGDRVRLSGEGEAGVHGGGSGDLYVQISLKKHAIFERHENDLHCEVPISFATAALGGSIEVPTLEGRVTLKIPAETQTGKVFRLRSKGMKSVRGYGQGDLLCKVVVETPVNLSREQKELLNKLQDSLENAKGTHSPKTSSWFAGVKKFFEDMKF
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEX_SHIFL
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS4_THESQ
Sequence: MLVVPAIDLFRGKVARMIKGRKENTIFYEKDPVELVEKLIEEGFTLIHVVDLSNAIENSGENLPVLEKLSEFAEHIQIGGGIRSLDYAEKLRKLGYRRQIVSSKVLEDPSFLKSLREIDVEPVFSLDTRGGRVAFKGWLAEEEIDPVSLLKRLKEYGLEEIVHTEIEKDGTLQEHDFSLTKKIAIEAEVKVLAAGGISSENSLKTAQKVHTETNGLLKGVIVGRAFLEGILTVEVMKRYAR
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_ACISJ
Sequence: MAVIKIKPTSPGQRGAVKISRDHLYKGEAFAGLLEPQFQKAGRNNNGHITTRHKGGGHKHHYRVVDFRRNKDAIPAKVERIEYDPNRTAHIALVCYADGERRYIIAPRNLEVGATIVSGSEAPIRVGNTLPIRNIPVGSTIHCIELKPGAGAQIARSAGTSATLLAREGVYAQVRMRSGEVRKIHIECRATIGEVANEEHSLRQLGKAGVKRWMGIRPTVRGVAMNPIDHPHGGGEGRTGEGRHAVDPWGNLTKGYRTRNNKRTQVMIVSRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: FACR2_DROME
Sequence: MAVITEHGGTTSSPPENNNSIGNGKHRVNGHQLSTSLTIPEFFAHKNIFVTGGTGFLGTVLIEALLDTHPDIGTIYVLVRGKRKFDPNERIRRLLQKPIFEKYSEKTLSKVVPVVGELSEPNFGFGPELLQELIDRVNVIYHSAATIKFSSPLRTAIRTNLTGTMRTIELAKQLKQLAAYIYCSTAFCNSNNRGLIAEEVYKSQFDPYEMMKMAEDDSAWEDFTDQKCKGYIRDHPNTYTFTKNLSENLLMAEMSGLPAAIVRPSIVYGTLEHPMKGWVGNANSGHLGFLAGFVKGIFRTMCGNANAVIDIIPCDYVINSSLVMGWYVGTRKLEQPEIIHCTSGEVNPLNLAEFCTIINDSVERHPPNSFVWKPVTKLRNGWRYNLFFYLFHLLPAMVFIIPEKLFGIGMPQHTAYEYMRVFQKGTKAFDYFLDKDFRYSLKNALRISALIPESDRRRYNFDASQCDWSEFIDRCLIGIRRFYFKESAVTTDWHRNYWKVFNVLYYAGYVVIFAVLYFALTLTLGLQIGLTLAVLIWGFLVWL
What is the function of this protein?
Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.
What are the official names of this protein?
Putative fatty acyl-CoA reductase CG8303.
What is the protein family that this protein belongs to?
Belongs to the fatty acyl-CoA reductase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y3251_SACS2
Sequence: MKITPIAFESLGVRSQATLIETKDLRVLVDPAVSLAPRRYNLPPHQREVDRLTQLAKVLVDVAKDVDVIVVSHYHYDHHDPGYVIPTDIYKNKIVFLKDPQNMINNSQKYRRAPRFLRSIKDKPRKIEIADGKTFEFNTTTISFSPAVPHGADERLGYVIQVAISDKDSTVIFTSDIEGAPKDVHLKFTKEKMPTVIIIDGPLSYLLGRALKEEELENSIRNMEEIIKNGLETVIIDHHVLRDINYAQVLKPVHDIAKDLGVRVTTAAEYLNLEPLILEARRKELYKEDNRPAKIPRGLANLLNAGDG
What are the official names of this protein?
UPF0282 protein SSO3251.
What is the protein family that this protein belongs to?
Belongs to the UPF0282 family.
Protein: RL22_CHLTA
Sequence: MFKATARYIRVQPRKARLAAGLMRNRSVVEAQQQLSFSQMKAGRCLKKVLDGAIANAESNENIKRENLCVLEVRVDVGPMFKRMKSKSRGGRAPILKRTSHLTVIVGERGQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RSMG_MICAN
Sequence: MILPELFDLWQETLEWQPDGAQQARFQQLYDLILEGNQRFNLTRITQPEEFWEKHLWDSLSGLAWLQKSQPDLLTKSLSVIDLGTGAGFPGVPIAIAYPHWSVTLLDSTQKKINFLEEVIDKLELNNTKTRLGRAEIVGKNLKHNCAYDIVCLRAVGNVDICVNYALPFLKKTGIAILYRGQWSAQDSLSLEENLGKAGGKILEIASFTTPLSESVRHCLYISKK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUN41_CANAL
Sequence: MRFSQATVLAFAALSLAAPAFEADNKNIKREDCDKTSFHGHHKHKRAVAYDYAYVTVTVDGNGNPITTVSPVLSIETIAKSEETSSTSTSISSTTTIVQNDSLTSDEPKTLSLPSGTIKPSSFATESQSQSQSSSTGGSGSGSTNGIEGDLAAFEDPTEEFEDGVLSCSDFPSGQGVIPLDHLGFGGWSGIENSDGSTGGNCKEGSYCSYACQSGMSKTQWPEDQPSNGVSIGGLLCKNGKLYKSSTRSNYLCEWGVKKANVVNKLSETVAICRTDYPGTENMVIPTVVGGGSTSVITVVDQSTYYTWRGGATSAQYYVNNAGVSWEDGCVWGTPGSGVGNWAPLNFGAGYANGIAYLSLIPNPNNRDSLNFKVKIVGESGSTVSGSCSYANGKFNGNSDDGCTVGVTSGEADFVLYN
What is the function of this protein?
Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction.  Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides.
What are the official names of this protein?
Secreted beta-glucosidase SUN41.
What is the protein family that this protein belongs to?
Belongs to the SUN family.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted. Note=Secreted into the medium of cells growing as blastospores as well as those forming hyphae (PubMed:17905924). Secretion is decreased in cells lacking VPS4 (PubMed:19819358).
Protein: GDL44_ARATH
Sequence: MSTSKAITLTLFITTTLLASCDAAANATTKPLFPAILIFGDSTVDTGNNNYPLPTIFRAEHFPYGMDLPDGKANGRFSNGKLISDIIATKLNIKEFIPPFLQPNLSDQDILTGVCFASAGAGYDDLTSLSTQAIRVSEQPNMFKSYIARLKGIVGDKKAMEIINNAFVVVSAGPNDFILNYYDIPSRRLEYPFISGYQDFILKRLENFVRELYSLGVRNVLVGGLPPMGCLPIHMTAKFRNIFRFCLEHHNKDSVLYNEKLQKLLPQIEASLPGSKFLYADVYNPMMEMIQNPSKYGFKETKRGCCGTGFLETSFMCNVFSPVCQNRSEFMFFDSIHPSEATYNVIGNRLDPLIRGKFQA
What are the official names of this protein?
GDSL esterase/lipase At2g31550, Extracellular lipase At2g31550.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: BACH_HALS4
Sequence: MRSRTYHDQSVCGPYGSQRTDCDRDTDAGSDTDVHGAQVATQIRTDTLLHSSLWVNIALAGLSILVFLYMARTVRANRARLIVGATLMIPLVSLSSYLGLVTGLTAGPIEMPAAHALAGEDVLSQWGRYLTWTLSTPMILLALGWLAEVDTADLFVVIAADIGMCLTGLAAALTTSSYAFRWAFYLVSTAFFVVVLYALLAKWPTNAEAAGTGDIFGTLRWLTVILWLGYPILWALGVEGFALVDSVGLTSWGYSLLDIGAKYLFAALLLRWVANNERTIAVGQRSGRGAIGDPVED
What is the function of this protein?
Light-driven chloride pump.
What are the official names of this protein?
Halorhodopsin, HR.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIPA2_PHATC
Sequence: MPKGRPSWFKVPAPSQGTQSTYSTASYSRYAQVKDSLQKLDLHTVCEEAQCPNIGECWNGGTGTIMLLGDTCTRGCMFCAVNTDSKPPPPDPFEPFKTAEAVVAWGVDYIVLTSVDRDDIADGGAQHFAQTVQLLKQNKPNLLVECLVSDFQGMLDSVETLALSGLDVYAHNVETVERLQPFVRDARANYQQSLSTLQHAKVVKPELYTKTSIMLGLGETEEEVTQTMTDLRAIGVDVVTFGQYLRPTEHHLSVVEYVTPEKFDHYRQVGENMGFKYVASGPMVRSSYKAGEFYLEHMIKKERTEAAIDIGENA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase 2, mitochondrial, Lipoate synthase 2, LS 2, Lip-syn 2, Lipoic acid synthase 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: WHI5_YEAST
Sequence: MSLRTPKRSRTSDEQEQEQEQEQVQNPDTHVNNEHQQRPGPTTLLSTPVRLKNGFGTPSPPSPPGITKSITKSRRRPSTTSLQGIFMSPVNKRRVGITAHGRVYDHNDDGHESESEDDENEEENENQKKYDGHVSMPLLPPTTPKSRRSEVFLSPSPRLRSPPTAARRSTGERPIREISHTLRTRLNYALVKLQNGWTDKTLPELETELAPAVQTPPRRYHNRFPDSADAGTSAHTAFLQALGGHPPREEATAVETLMLLSSPTKKQQHRPVPATSAGEPTDETEPESDTEVETS
What is the function of this protein?
Transcriptional repressor that negatively regulates G1-specific, SBF- and MBF-dependent transcription.  Binds via SBF to promoters of G1-specific genes to repress transcription in early G1.  During G1, phosphorylated by cyclin-CDK CLN3-CDC28 and progressively hyperphosphorylated by CDK associated with other G1-cyclins, which leads to dissociation of WHI5 from SBF, activating SBF-dependent transcription in late G1.  Elimination of CDK activity at the end of mitosis by the mitotic exit network (MEN) allows WHI5 to reassociate with SBF to again repress G1/S transcription.
What are the official names of this protein?
G1-specific transcriptional repressor WHI5.
What is the protein family that this protein belongs to?
Belongs to the WHI5/NRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles in a cell cycle-regulated manner. Localizes to the nucleus, where it is associated with SBF- dependent promoters. In late G1 phase, phosphorylation by G1-specific cyclin-CDK causes its export to the cytoplasm. Elimination of CDK activity at the end of mitosis allows WHI5 to reenter the nucleus.
Protein: TSHR_HUMAN
Sequence: MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
What is the function of this protein?
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258).  Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).  Plays a central role in controlling thyroid cell metabolism (By similarity).
What are the official names of this protein?
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: ACRBP_PIG
Sequence: MRQLAAGSLLSLLKVLLLPLAPAPAQDANSASTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFTQYRCSNHVYYAKRVRCSQPVSILSPNSLKEVDTSSEVPITTMTSPVSSHITATGRQVFQPWPERLNNNVEELLQSSLSLGGQEQGQEHKQEHKQEQGQEHKQDEGQEQEEQEEEQEEEGKQEEGQGTEESLEAMSGLQADSEPKFQSEFVSSNPFSFTPRVREVESTPMMMENIQELIRSAQEMDEMGDVYEEENIWRAQSPGSLLQLPHVDALLVLCYSIVENTCVITPTAKAWQYLEDETLGFGKSVCDSLGRRHLAACSLCDFCSLKLEQCHSETNLQRQQCDNSHKTPFISPLLASQSMSIGTQIGTLKSGRFYGLDLYGGLRMDFWCARLATKGCEDNRVASWLQTEFLSFQDGDFPTKICDTEYVQYPNYCAFKSQQCMMRNRDRKVSRMRCLQNETYTVLTQAKSEDLVLRWSQEFSTLTLGQAG
What is the function of this protein?
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome (PubMed:8144514).  Involved also in the acrosome formation (By similarity).
What are the official names of this protein?
Acrosin-binding protein, Acrosin-binding protein, 60 kDa form, Proacrosin-binding protein sp32.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Appears to be present only in the round spermatids and elongating spermatids. Colocalizes in the acrosome with proacrosin.