PharMolix/UniProtQA huggingface dataset:
Protein: VATB_HYPBU
Sequence: MEAAMGPSPVIREYETIREVRGPLLIVEGISDAAYDEIVEVELPSGERRRGRVLETARGYAVVQVFEGTTGISVTGTKVRFLGRTLEIKVSDEMLGRVFNGLGDPIDGGPPITSGVRRDINGEPLNPAARAYPEDFIQTGISAIDGMNTMVRGQKLPIFSGSGLPHNKLAVQIARQATVRSGEEFAVVFAAIGVMYDEAIFFKRFFEETGAIKRAALFINLADEPASVRLITPRVALTLAEHLAFDLGMHVLVILTDMTNYCEALREISAAREEVPGRQGYPGYMYSDLASIYERAGRAHGRKGSITQMPILTMPNDDITHPIPDLTGYITEGQIVLSRELHNRGIYPPINVLMSLSRLMKEGIGPGKTREDHANVSDQLYTAYSRAVELRSLAAIVGEESLSEVDRKYLRFGEAFEQRFLKQGFYENRSIEETLDLAWEILSILPESELYKIKDEYIRKYHPKYRKKQSQSSGGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: FLHO_BACSU
Sequence: MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAFPEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQVPMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNENFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAYSLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI
What is the function of this protein?
Not required for motility.
What are the official names of this protein?
Flagellar hook-basal body complex protein FlhO.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
Protein: FEN11_LACBS
Sequence: MGIKGLTGLLSQHAPKAIQEHEIKTLFGRKVAIDASMSIYQFLIAVRQKDGELLTNDAGETTSHLMGLFYRTLRIVENGIKPAYIFDGKPPELKKGVLSKRLERREEAKEEGEEAKETGTVEDVDRFSRRTVKVTREHNEECRRLLRLMGIPVVIAPSEAEAQCAELARGGKVYAAGSEDMDTLTFNAPILFRHLTFSEAKKQPISEINLKEALEGLDMNMSQFIDLCILLGCDYLEPIKGVGPKSALKLIREYGGLKGVVKHLRENSGCRGMQIPDEWPWEEAKKIFEKPDVLPADEVELEWTNPDVDGLVQFLVKEKGFNEDRVRKGAEKLQKFLNSKQQGRLDGFFSVKPKEKAAAPAPVGKAKGKGKVDAKAKGTKRKVGFLNSMSGPLA
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1-A, FEN-1-A, Flap structure-specific endonuclease 1-A.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: UBIE_ECOK1
Sequence: MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: OFUT2_ARATH
Sequence: MGQERPNDEERPESRDLGVYGCSPPHSPRLGPTRFYVFAGDPNPKQTIKRCKRKRIQACNDQRTAKTAIGVMAILGFFCLVNWFMLSRLHEGRVWLRRGLSENPKHVSAQNEERKKFEKQKMKYNGTYGRMLSLATDALAEGMRDNRYCNGFDFEQNKLETKDLWQEPKEQASAWKPCADQRSLTPDDGKNGYIMVTANGGINQQRVAVCNIVVVARLLNAALVIPKFMLSDVWTDASQFGDIYQEEHFMEYLSPDIRIVKELPKELQSLNLEEIGSVVTDIEVMKEAKPDFYMTHILPILLKNRVIHFVGFGNRLAFDPLPFELQRLRCRCNFHALNFVPRIQETAALLVKRLRGSGSYYLALHLRFEIDMVAHSLCYFGGGETEQKELDSYRQKHFPSLSTLTRKKKFRSADVLRTEGLCPLTPEEAVLMLAALGFNRETRVFVAGANIYGGSKRLAVLTSLYPNLVTKEKLLTESELQPFKNFSSQLAALDFIACAAADAFAMTDSGSQLSSLVSGYRIYYGGGKLPTIRPNKRRLSDILLKNSTIEWNVFEKRVRKAIRQTKHVFARPNGRSVYRYPRCKECMCHA
What are the official names of this protein?
O-fucosyltransferase 2, O-FucT-2, O-fucosyltransferase family protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase GT106 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RAD54_DROYA
Sequence: MRRSLAPSQRGPMRPESRHSFTPPLLKKNKRSCQQELEREQELDRKRQSALRDASNTMDLPLPIRFTANSEYERAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPVACNALVLFNPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLQGRLLCLPMEGGTKENTIRALEQFSMTSSRLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEGERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTSIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEKITAREKGFENSQNVLPSNYNTKDLNPELSGKFMLLDFMLAAIRADGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRMVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKDLFTFDADILSDTHEKLKCKRCVQNVQVKPPPDNTDCTSHLSQWYHCSNNRGLPDNILAQAWTDCKCVSFVFHHRSQAQEIVAIAEEAASEQPEEKPDRRKRPSTPPSDDSADEDFLGF
What is the function of this protein?
Involved in mitotic DNA repair and meiotic recombination.  Functions in the recombinational DNA repair pathway.  Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51.  In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54 (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RAD54-like, Protein okra.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSPLL_ARALL
Sequence: MAPPPPSPPPVSLKVSLLLLRVLTGVFLVIALIILSTNSVTIVSQGSALKFHFKDVYAYRYMLSAAVIGLLYAVIQLFFTISEFATGMKNPFNYQLDFYGDKLISYLVATGSAAGFGVSKDLKDAFIALVALDSTDPVDKFFSRGYASASLLLFSFICLAVLSVFSSLAIAKRN
What are the official names of this protein?
CASP-like protein 4D2, AlCASPL4D2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1348_METJA
Sequence: MRCLELNWEIMNKDSSNFLYKYWLKGCEFYNKKDYDKAIEYFSLSNKIFKENVPKCDYYGLREEAYKEILNNNIEEGIKKFDWFVEGILADGDYYNLSGELSTIASIFAKIGKLDITKNFLNSGGEWIYNDVIKDANSEDILKSVLTFDFSYEERKEILNREPHLRKLFEDNIYNFNSDFFDFMMMFFIGAGNWKRFLEVYEEFKNKIKSCQISNEIVNEIIKRFDKSMSDLLAIAHLLKENYEKCLYYVMLFKEYFDLDEFNEIEKNKINLIVDIAYNLKNGNVKKEEWLNRLNEIYKEIIKRPLPNTYKDAHNDDLLNEILDYYVLKEFIEKKL
What are the official names of this protein?
Uncharacterized protein MJ1348.
Protein: RL4_STRE4
Sequence: MANVKLFDQTGKEVSTVELNDDIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVESLSFAAPKTAEFAKVLSALSIDTKVLVLVEEGNEFAALSARNLPNVAVATAATASVLDIVNADKLLVTKEAISTIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CAP7_HUMAN
Sequence: MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA
What is the function of this protein?
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein.  Binds heparin.  The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.  It may play a role in mediating recruitment of monocytes in the second wave of inflammation.  Has antibacterial activity against the Gram-negative bacterium P. aeruginosa, this activity is inhibited by LPS from P. aeruginosa.  Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A. actinomycetemcomitans ATCC 29532, A. actinomycetemcomitans NCTC 9709, A. actinomycetemcomitans FDC-Y4, H. aphrophilus ATCC 13252, E. corrodens ATCC 23834, C. sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E. coli ML-35.  Has antibacterial activity against C. sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
What are the official names of this protein?
Azurocidin, Cationic antimicrobial protein CAP37, Heparin-binding protein, HBP, hHBP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
What are the subcellular locations of this protein?
Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides.
Protein: AROE_AGRFC
Sequence: MADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKEGKPGAAVGGNATIPHKEAAYRLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNLDERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVVNRTVERARELADRFGPRVFSHPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQEQGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: NIFH2_TRIV2
Sequence: MIDNIRQIAFYGKGGIGKSTTSQNTIAGLAEMGERIMIVGCDPKADSTRLMLHSKAQTTILHLAAERGAVEDLELDEVLLTGYQGVKCVESGGPEPGVGCAGRGIITAINFLEENGAYEDLDFVSYDVLGDVVCGGFAMPIREGKAQEIYIVCSGEMMAMYAANNIARGILKYAHSGGVRLGGLICNSRNVDREVELIEALAERLNTQMIHFVPRNNVVQHAELRRMTVIEYATEHPQANEYRTLAKKIKENTKLTIPTPISMDELEELLVEFGILGGEEEYQKAIAQDAGKAVVV
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 2, Nitrogenase Fe protein 2, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: TM252_PONAB
Sequence: MQNRTGLILCALALLMGFLMVCLGAFFISWGSIFDCQGSLIAAYLLLPLGFVILLSGIFWSNYRQVTESKGVLRHMLRQHLAHGALSVATVDRPDFYPPAYEESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIASLVVTAISEDAQRRGQEC
What are the official names of this protein?
Transmembrane protein 252.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LPXD_PHEZH
Sequence: MPDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLPGLARLEGACFVQARDASVLPDGCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLEPGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECDIGANVTLGFALLGDRVRILAGAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNLVQIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKDIPAGETWGGMPARPIRHWLKETAWLARMANRRGPDGKGAGNDA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RL33_VIBC1
Sequence: MAKKGVREKIRLVSSAGTGHFYTTDKNKRNMPGKFEIKKFDPVVRQHVMYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MURI_SHEB2
Sequence: MSRPILVFDSGIGGLSVLAEIRKSLPHSDYCYLFDNARLPYGELEEQVLIAGCVALVCDLVARTNAMIVVVACNTASTVVLPALRANLSIPVVGVVPAIKPAAQMSKSKRIGLLATPGTVKRHYTHSLISQFADDCHVELFGCSELVMMAEQKIATGEMDMHRLADLLAPVVAAQLDVLVLGCTHFPMIQAELQQVLGAGVTLMDSGAAIAKRVVTLLTQQNFIVEQRRVTNEREAVGESAMQAFYTKAEISEGLTTTLIDCGFSTIERITTTN
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: ATPA_PSEPF
Sequence: MQQLNPSEISEIIKGRIEKLDVTSQARNEGTVVSVSDGIVRIHGLADVMYGEMIEFPGGVYGMALNLEQDSVGAVVLGAYTTLAEGMSAKCTGRILEVPVGKELLGRVVDALGNPVDGKGPLGNTETDAVEKVAPGVIWRKSVDQPVQTGYKAVDAMIPVGRGQRELIIGDRQIGKTALAIDAIINQKDSGIFCVYVAIGQKQSTIANVVRKLEENGALANTIIVAASASESAALQFLAPYSGCTMGEFFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVSEEYVEKFTNGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESAMFNSGIRPAVNAGVSVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPMSIADMSLSLYAAERGFLTDIEITKIGSFEQALIAFFNRDHADLMAKINVKGDFNDEIDAGLKAGIEKFKATQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SUB7D_COCP7
Sequence: MRAIISVALFLSLSLLSAVNAAEILSAGDTDDVIPDSYIVVMRDGLSTDAFNSHTTQISGFRNEDRNVKASLKKTFDLNGLKGYSGTFDEATIRQIANDPAVKYIEHDRIANARGLVEQQDAGWNLARISHKKTGARTYVYDKSAGAGISVCLVDTGVDVDNPDLGGRATWGANFVDNDDSDGNGHGTFLASLIAGQKHGVAKKAKIIAVKVLDANGSGSYSNVISGIDWCVKYAKEHGISERMVVNLSLGGGYSQAVNQAAENAVLAGMFVSAAVGGSNRDARNDSPASARGVCAIAASTMDDKAALFSNYGSIVAVYAPGQNIMAAGRMGSVTLSGTSFAAGHASGVGAYLLALEKITGDRVCTRIKELAIPVIRNSPSNTTRLLLYNGSGR
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease CPC735_005570.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NEUR3_BOVIN
Sequence: MEEVTSCSFSSPLFQQEDKRGVTYRIPALIYVPPAHTFLAFAEKRSSSKDEDALHLVLRRGLRTGQSVQWEPLKSLMKATLPGHRTMNPCPVWERKSGYVYLFFICVQGHVTERQQIMSGRNPARLCFICSQDAGYSWSDVRDLTEEVIGPEVTHWATFAVGPGHGIQLQSGRLIIPAYAYYIPFWFFCFRLPYRARPHSLMIYSDDLGATWHHGRLIKPMVTVECEVAEVIGKAGHPVLYCSARTPNRHRAEALSIDHGECFQKPVLSHQLCEPPHGCQGSVVSFCPLEIPGGCQDLAGEDAPAIQQSPLLCSSVRPEPEAGTLSESWLLYSHPTNKKRRVDLGIYLNQSPLEAACWSRPWILHCGPCGYSDLAALENEGLFGCLFECGTKQECEQIAFRLFTDREILSHVQGDCSTPGMNSEPSKK
What is the function of this protein?
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides.  Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:9988745).  Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR.  Desialylates EGFR and activates downstream signaling in proliferating cells.  Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity).
What are the official names of this protein?
Sialidase-3, Ganglioside sialidase, Membrane sialidase, N-acetyl-alpha-neuraminidase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
Protein: TICRR_HUMAN
Sequence: MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL
What is the function of this protein?
Regulator of DNA replication and S/M and G2/M checkpoints.  Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins.  Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC).  Required to prevent mitotic entry after treatment with ionizing radiation.
What are the official names of this protein?
Treslin, TopBP1-interacting checkpoint and replication regulator, TopBP1-interacting, replication-stimulating protein.
What is the protein family that this protein belongs to?
Belongs to the treslin family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: SSN2_CANGA
Sequence: MKEATDDYDLSKLVSNFYRLEKITKINYAQYLPKKQNDQWGIQMEIQMRKKDRKLLVALLSKELWCFSINDQVLPSPNDIDPELNVSADKTGSFTADYSKPNLPPHYALFLKSLKRMIYLNLVEQSKNTLVQFGNSCINITKNNESNNLLQIEPHLFSNSELAISICVKDLGLLPLKVNSIDPAFLSSHALYMAPSGVRVYLVENKNDNSGTNQEHLHKYLVPVPENGEVLLKTLYASHGIKLNSSTCQWVNIIPNITHLNGRAPNISQYMDLPKELRTIVWPLDLVFAQPALDIDSSTTLSQINGLDTFEDTLSLIDNFLQLKQSSSYRTPGSSGGLTGTNIGTNVFSSEGAYTDQFQVYPKSQTNQQQTSSNSKVSPSDAASPYPGIDKIIEQKQFTPDFMASPSVSGNSNELFNDRKNGHTDLLISPSKMDVDTDFPGSNLAGQEAPSQPASDVKKSSVSASDSELFGEEDEDEDDADLFGESNNDSTGESNANNSKGEITEDIFASSDDESSLQPKKESTFYDGIKNGSAESGLNMQDRANLKRTYLDIRIEETPLSSPLYTDPGAPLPVETPRDRRKSVFAPLNFNPIIAKDVDNKYKNGGKYSFSPLQKEEALNFDVSRTELSSSEGEDSESSDDELEDLANKNDGVVYDKAENIGYKTFANLQDSVPPGLIKQDFLGNPYLASLEGSKEGQNTIWKMPQTDIAQTESPLKAIDTSIGPDGTLPNTTSSEQSKSVYVHDYGISPTKMSNDPAFDTAKIEGKYEFMNNFPSSFPFLLRHMPLSLIPDTFKHLNPTITVNERNNQIIDLLAEQIVYDYNILGNLTIPDVPYSGIRNYSNGVVKNTIDNLFSEFTRLDGTTLISRLYPMETPFVSVRKQHDQIKLRSDVQQFTKYANLKPVRGIKNFKFLVLTDSFKEDCIQFISSLSQTYINHELGFCEHLQLTNEDSKGLIYLKDFEDSKLLLLAAQIVSYLSTNRTSGKEVAFMMIIPVQRCDISELVEKTAKFQIIQNEVKAKIPSMELYLKIVPMDFIKSPLTSVDDYTNLCISIYNILPNKMIKFTHIRKQIPEKLTFKTSQQASAFKYDAYIHLAYSRSVDKQWMFAALSDSAGKENMMKTWYLGSSKNKFDEACNHIWEMALSLAGKNYGKVCLILTRLNGILPDDELMNWRRLSGRNIHLAVVCVDDNTKISFFDRNESYPSYKRLYQNANSIETLVDPERIDDYLIRDLDQDIHGVIFENPFPLVNSLHRCAIKSGALVKFNVSTTATEPHSLDKFEVNLLNCPHSDSFKLLETILEEFRNLAALNVWFGITNGENGHIPWHVLAVKKMMKTLVHTRVKVAQ
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 13, Mediator complex subunit 13.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 13 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRP4L_ARATH
Sequence: MEPNKDDNVSLAATAQISAPPVLQDASSLPGFSAIPPVVPPSFPPPMAPIPMMPHPPVARPPTFRPPVSQNGGVKTSDSDSESDDEHIEISEESKQVRERQEKALQDLLVKRRAAAMAVPTNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDINGQLDKLVKDHEEDVTPKEEVDDEVLEYPFFTEGPKELREARIEIAKFSVKRAAVRIQRAKRRRDDPDEDMDAETKWALKHAKHMALDCSNFGDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTDGTLLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQEGYFLATASYDMKVNIWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLWTSSGNDDEDEEKETMDIDL
What is the function of this protein?
Participates in pre-mRNA splicing.  Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity).  Essential for reproduction.  In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success.  Involved in a mechanism that prevents accessory cells from adopting gametic cell fate (PubMed:17326723).  Modulates egg cell signaling center that regulates the development of all female gametophytic cells (PubMed:22190635).
What are the official names of this protein?
U4/U6 small nuclear ribonucleoprotein PRP4-like protein, Protein EMBRYO DEFECTIVE 2776, Protein LACHESIS.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Colocalizes with CLO.
Protein: H4_MYTCH
Sequence: MSGRGKGGKGLGKGGAKRHRRVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.