PharMolix/UniProtQA huggingface dataset:
Protein: IF2_GLUDA
Sequence: MSEGNDQDQGKGRLSLRPAGRKDVGRTVDAGSVRQSFSHGRSKVVQVEVRKKRGPGPAPAGSGSGSSGGGRAGGRGGSGGRALTASELATRQRVLEEQRAEAVRREQERREQEKIMILSAAEEARRRDEEARRAAEDEVREKEEAAARAREEEAERRASAQAHGQAGTPSRAEPEPESSGPVVSAVPIPGAVTLAPPMERLRPLAERAIMPARPVTPSRPATPAATPQAPGETLRLRTGRVGEAEDDRRPARRPGGGIAPGRKPSGASPKKGGDSRRSGRIDVQAAIEGDDDKTRSLASVRRQRERERRQAELERLRADQVRVVRDVILPETITVQELANRMAARQGEVIKALMKMGVMATVTQSLDADTAELVVQEFGHRVRRVADSDVEIGIEGIEDQPEDLLPRPPVVTVMGHVDHGKTSLLDALRTTDVAAAEAGGITQHIGAYQVTLPSGSKITFIDTPGHEAFTAMRARGASVTDVVVLVVAADDGVMPQTIEAIRHAKAANAPIIVAINKCDKPGANPERVRQELLSHEIVVESMGGDTQDVEVSALKRTGLDKLEEAILLQAEMLDLRANPDRVAEGSVIESRLDRGRGPVATVLVQKGTLRRGDIVVAGAEWGRVRAMLDDRGRQIQEAAPAMPVEILGIAGVPGAGEPFVVVDNENRAREISEFRQRVIRDRTAAGQTAARGTLDQMLARIQAGAQKEVAVLIKADVQGSAEALQATVLKLEHEEVKVRVLTAGVGQITESDVQLAKASDAVIIAFNVRATTQARELAQREGVDIRYYSIIYQVADDVEQLVKGKVAPKHREKFLGYAEIRKVFDITKVGKVAGCYVTEGVVKRGCGVRLLRDNVVVHEGELSQLKRFKDDVKEVARGYECGLSFAGYNDLREGDMVECYEMELVPA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_LIMRD
Sequence: MLKPLGDRVVLKAETEEEKTVGGIVLASNVKEKPTTGKVIAVGEGRTLENGQKLAPAVKEGDRVLFDKYAGNEVEYNGEKFLVVHAKDLVAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKT1_TRYB2
Sequence: MYPRHDDVSLFQRFVNDHKLEEKGLPLYQLAQLEGTDQVMLGVDGTKIIDMITQAVREREKMAIYTYTTPYTVYEKINEFRTMFQSIKNCTPVFVFNGIQYSPDSAEEFGREKNVVPSEVAALTGTDSSRLSNTTNVRFAEIHKKTANRFVVEEDVEGQIIRIFRSEFKNTIRAPYLAWAQLSSFRHCNHRHISEVYGCLELLAFPGIDRVVTNINPTRGTFDVVYKARVLEAARLSEEDLSSLILVESRSRVMRTVTLKFSSLEDMIKKVVRYKGSTIGASFAQQLHEEAIRASEANRMRASNQRGAAFRNLSAFASPVLTLTPPHCLPLHFLYGIPGFPHADAESFVGLPLPPVLYYIMSAGLLSPSLFAAVSQETVVDDWPLVDSIKYRDVAETVLPLRVQTIYQLAWTMSRGLGSISWFRRYNVLPARVSKLHVPPAIQLDGWALHSVTVPRGLHLVDVMEFAHLACSVDQVIYNTMEETYAAILLQSLDLLGYLTHETQDLHEEGQSSEPSTFGRALQLCSVPTLSEYTVLLIELARTNAISTEPFRITTEEVSPRDTPRDIVFASRVLSIIPLNVSGPWTAPIDAELAAFSMLSRMISRSIRQLLEAITTLMFSKGRTHVPLHRIGEIQRLLPFSTPVEFGCGVLVEYMLMKDKCTLKDLEEAFPECTYLRHDLATLFYFWDLAVQVLQRIETKENFCVDQHCLSSANERMKRAQKNLNILTGVRETYY
What is the function of this protein?
Involved in post-transcriptional regulation of gene expression (PubMed:24470144).  Promotes mRNA stabilization by recruiting a complex containing PBP1, LSM12 and XAC1 to mRNAs (PubMed:24470144, PubMed:32532821).  Recruited to mRNAs by sequence-specific RNA binding proteins (PubMed:24470144).  May regulate translation through interactions with the EIF4E6-EIF4G5 translation initiation complex (PubMed:32532821).
What are the official names of this protein?
Post-transcriptional regulator MKT1, Inactive endonuclease MKT1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, Stress granule. Note=Localizes to polysomes (PubMed:24470144). Partially localizes to starvation- induced stress granules but not to heat shock-induced stress granules (PubMed:24470144).
Protein: HSP7C_ICTPU
Sequence: MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTIFDAKRLIGRRFEDSVVQADMKHWPFKVISDGGRPRLEVEYKGEAKNFYPEEISSMVLVKMKEIAEAYLGKSINNAVITVPAYFNDSQRQRTKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGSERNVLIFDLGGGTFDVSILTIEDGIFDLKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISDNKRAVRRLATACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLDPVEKALRDAKMDKAQVHDIVLVGGSTRIPKMEKLLQDFFNGKELNKSINPDEAVAYGAAVQAESSLGDKSENVQDLVLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDKHKILDKCNEVISWLDKNQTAEKDEYEHQQKDLEKVCNPIITKLYQSDGGMPGGMPDGMPGGFQELGAAPGGGSSGPTIEEVD
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes.  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones.  The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state.  In the ATP-bound form, it has a low affinity for substrate proteins.  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins.  HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
What are the official names of this protein?
Heat shock cognate 71 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MSCL_BURVG
Sequence: MSIIKEFKEFAVKGNVMDLAVGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFILLGTIPPSFKGNPDSFKDLQAAGVAAFGYGSFITVAINFVILAFIIFLMVKFINKLRKPAEAAPAATPEDVLLLREIRDSLKQR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASTG_ASPOR
Sequence: MGEQTEFEPIQLSPLDQAIPPVYIRILLCFSVVNVDRAISQLQTGVSSLLSALPFLSGDVVRYTAPGKTKWLYQLCPPTHQVQATGVLVVKHHQMRCMVDEKRFAPSSTSHIPLSPFAEPARPAPIFRVQANAYIDGITLGFAFHHIAVDATGMGVIISELARHCRSSPPPSLLCPDYERATRQLISNSRATECSGLDHSGDYISCQALSPPAEGSEDASPSIEISTETRTFVFPAARLESLKNACIEMLPTLDQQQRQQNPCLDEPARTKVPWLSTNDVFVALLWVCLTRCRYQEDQNSGLPSDEHTRICMGVNMRSRIQPPLSADYLGNAILSLSFKLNVNVFRRTQVTNESIEGVDSKDIEHKQWLATICRVARNIRRGVNGMDDSYFRSVVSFLEDSSDCRLFDYARCDFCVPSWRHLCVYHADFGEMGRPKSLEVFDVPGDGSFCILPQHYGAAAPWELLLGLLKA
What is the function of this protein?
O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities (PubMed:27628599).  The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate (PubMed:27628599).  Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK (PubMed:27628599).  Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE (PubMed:27628599).  The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin (PubMed:27628599).  The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively (PubMed:27628599).  Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B (PubMed:27628599).
What are the official names of this protein?
O-acetyltransferase astG, Astellolide biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the fumigaclavine B O-acetyltransferase family.
Protein: RU17_YEAST
Sequence: MNYNLSKYPDDVSRLFKPRPPLSYKRPTDYPYAKRQTNPNITGVANLLSTSLKHYMEEFPEGSPNNHLQRYEDIKLSKIKNAQLLDRRLQNWNPNVDPHIKDTDPYRTIFIGRLPYDLDEIELQKYFVKFGEIEKIRIVKDKITQKSKGYAFIVFKDPISSKMAFKEIGVHRGIQIKDRICIVDIERGRTVKYFKPRRLGGGLGGRGYSNRDSRLPGRFASASTSNPAERNYAPRLPRRETSSSAYSADRYGSSTLDARYRGNRPLLSAATPTAAVTSVYKSRNSRTRESQPAPKEAPDY
What is the function of this protein?
Involved in nuclear mRNA splicing.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein 70 kDa homolog, U1 70K, U1 snRNP 70 kDa homolog, U1-70K, U1 small nuclear ribonucleoprotein SNP1, U1 snRNP protein SNP1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NIP31_ARATH
Sequence: MAEISDITTQTQTVVLDIENYQSIDDSRSSDLSAPLVSVSFVQKLIGEFVGTFTMIFAGCSAIVVNETYGKPVTLPGIALVWGLVVTVMIYSIGHVSGAHFNPAVSIAFASSKKFPFNQVPGYIAAQLLGSTLAAAVLRLVFHLDDDVCSLKGDVYVGTYPSNSNTTSFVMEFIATFNLMFVISAVATDKRATGSFAGIAIGATIVLDILFSGPISGASMNPARSLGPALIWGCYKDLWLYIVSPVIGALSGAWTYGLLRSTKKSYSEIIRPNCNKVSSRDRQEASQDEICVLRVVDPANQNYFICSSPTDINGKCNVTCKLA
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Aquaporin NIP3-1, NOD26-like intrinsic protein 3-1, AtNIP3;1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRPF_CANAL
Sequence: MKVVKICGIKTVEAASVAIDNGANLLGCILVPNRARTIDLEVAKQIARMVKRDRNPPPKFAGGTSTQHFEQVAQWIIENGPFLVGVFRNQPKEEVFRIAREVGLDFIQLHGSEDKLEFLGTEFGLIPRYVVPDELDLLEEQSLSLTQCVSLPLLDSEVGGEGKLLDWTFIEKLPTKAILAGGLTPENLPTFDNILGYDVSGGVETNGVKDSLKIIKFIQKGHAQSS
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RNPA_SODGM
Sequence: MVKLAFPRELRLLTPNHFTFVFQQPQWAGTPHVTILGRLNTLGHPRVGLTVAKKHVKRAHERNRIKRLTRESFRLHQHALPTMDFVVIAKKGVADLDNHTLTEALEKLWRRHCRQSQSC
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL15E_PYRAB
Sequence: MGMYKYIREAWKSPKKSYVGQLLKQRMIKWRREPAVVRIERPTRLDRARALGYQAKQGYVIVRVRVRRGGRKRPRWKGGRKPSKMGQVKYSPKKSLQWIAEEKAARKFPNLEVLNSYWVGEDGMYKWFEVIMVDPHHPVIKSDPKIAWIALKHHKGRVFRGLTSAGKKGRGLRNKGKGAEKIRPSIRANEGKGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: MAP12_DICDI
Sequence: MNKILKNIINKSSINNVFKTSFNGGISSSSSSSSSYLNNNNNIIKSYNVQQKQQQRYYSSFEDDLSPKKLKEKILENETEEIRDFVRSQRLTKKTASPLEGMNRKERRKMTTKLYRNPDNLIRGGIVSPQPLIPAHIKKPKYVLGEPVIDFEIDDPIEIHTAESIEHMRVVGKMAKEVLEYAGTLVRPGITTDEIDKLVHQNIIDRGAYPSPLGYKGFPKSICTSINEVLCHGIPDDRPLEFGDIVKIDVTLYYNGYHGDTCATFPVGEIDSSSKRLIEATEKALYAAIGEVKDGALFNKIGKKIQLVANKYSLSVTPEFTGHGIGQLFHTAPFVFQCANEFDSVMKEGMIFTIEPVLVESTSPYAEWKMWDDKWTVSSREGGWSAQFEHTILVTKDGYEILTK
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 1D, mitochondrial, MAP 1D, MetAP 1D, Methionyl aminopeptidase type 1D, mitochondrial, Peptidase M 1D.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CTRB_NEIMA
Sequence: MSEQLPVAVATETKAERKKPKKKSWIKKLSPLFWVTVIIPTVISLVYFGFFASDRFTSQSSFVVRSPKSQSSLNGLGAILQGTGFARAQDDIYTVQEYMQSRSALDALRKKMPIRDFYEKEGDIFSRFNGFGLRGEDEAFYQYYRDKVSIHFDSVSGISNLSVTSFNAGESQKINDALLKQGEVLINQLNERARQDTIRYAQEVVNSAEEQVKEASVQLTKFRVSNGIFDLKAQSDVQMGLVSKLQDELIVIQTQLDQVKAVTPENPQIPGLIAREKSLRKEISQQMKAISGGGEGSLSNQAAEYQRVYLENELAEKQLAAAMTSLESAKAEADRQQLYLEVISQPNKPDLAYEPNRLYNIVATFVIGLIVYGIVVLLSASIREHKN
What is the function of this protein?
May form an ATP-driven capsule polysaccharide export apparatus, in association with the CtrC and CtrD proteins.
What are the official names of this protein?
Capsule polysaccharide export inner-membrane protein CtrB.
What is the protein family that this protein belongs to?
Belongs to the BexC/CtrB/KpsE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BTD_DROME
Sequence: MIDAACNYLNPYAQQHQAQQQQHAQHQQHAQQQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQQQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMKLELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGALAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLCLTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTPLVNYAPYANLYQHSTSAGSSVNPPPPPPPLFQQQMTTTTSSAAASFVEQPWSSSSSRAIQPATTSASSSSSSSASSPAAAVVSAIGSASSPAASATALAQHHYAALAMQSESQLAAEYGLTMSGLASGASQDSSSSCHMKSEYAASYPADFGAGTASYGYPHPHPHHHNAWAAAYHPHATA
What is the function of this protein?
Required for the development of the antennal, intercalary and mandibular segments of the head.
What are the official names of this protein?
Transcription factor btd, Protein buttonhead.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSPQ_PROMH
Sequence: MMIASKFGIGQQVRHKLLGYLGVVVDVDAEYSLDQPNEDDIASNMTLRSAPWYHVVMEDDEGQPVHTYLAEAQITYELSDEHLDNDSMDELSQSIRNQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_SHESW
Sequence: MKRTIIMMLDSFGVGASADAASFGDVGSDTFGHIAKACAEGKADIGREGPLKLPNLARLGLGHAAMESTGAFAPGFGDNVELIGAYGHAQELSSGKDTPSGHWEMAGVPVLFEWGYFSEHQNSFPKELTDKILARAGLDGFLGNCHASGTTILEELGEEHMRSGKPIFYTSADSVFQIACHEETFGLDNLYRLCEITREELAPYNIGRVIARPFNGTGPSDFARTGNRKDYSLEPPAKTVLDKLKAAGGEVVSVGKIADIYAYCGITKKVKANGLEDLFDATLAEVKSAGDNTIVFTNFVDFDSHYGHRRDVAGYAKGLEYFDARLPEMLALLGEDDLLILTADHGCDPTWQGTDHTREYVPVLAYGAGLKAGSLGRRNSFADIGQSIASHFKLEPMAYGESFI
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_LEIXX
Sequence: MQRLEFSESERSTVGIEWELALVDGATGDLVPIAKEVLGELGTSDGREHPQITHELLMNTVEVVSQVHRTVPAAIADLQELIGMVREVTDPRGVELMCAETHPFAQWYDQRITPSERYDRLLDRTQWWGRQMMIWGVHVHIGIDERDKALPIVNGLLTYYPHLQALSASSPFWAGANTGYASNRALMFQQLPTAGLPWQFGAWANYEEYVQDLVTTGVVTDHSEVRWDIRPSPKWGTVEMRACDGLSTADEVGAVAALIHCLTDQMLGELDDGVKPVTLQPWFVRENKWRAARYGLDAEVIVAPDGAERLVRDELAELTETLAPIAERLGCAEQLAQVHTILRTGASYQRQLAVAEANGGSLQEVVSSLTNELRNGLG
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: AGAA2_SHESA
Sequence: MKPNTDFMLIADGAKVLTQGNLTEHCAIEVSDGIICGLKSTISAEWTADKPHYRLTSGTLVAGFIDTQVNGGGGLMFNHVPTLETLRLMMQAHRQFGTTAMLPTVITDDIEVMQAAADAVAEAIDCQVPGIIGIHFEGPHLSVAKRGCHPPAHLRGITEREWLLYLRQDLGVRLITLAPESVTPEQIKRLVASGAIISLGHSNADGETVLKAIEAGASGFTHLYNGMSALTSREPGMVGAAFASENTYCGIILDGQHVHPISALAAWRAKGTEHLMLVTDAMSPLGSDQTEFQFFDGKVVREGMTLRDQHGSLAGSVLDMASAVRYAATELNLGLSNAVQMATRTPAEFIQRPQLGDIAEGKQADWVWLDDDQRVLAVWIAGELLYQAEQARFA
What is the function of this protein?
Involved in the pathway of N-acetyl-D-galactosamine degradation.  Catalyzes the conversion of N-acetyl-D-galactosamine 6-phosphate to D-galactosamine 6-phosphate and acetate.  It can also catalyze the conversion of N-acetyl-D-glucosamine 6-phosphate.
What are the official names of this protein?
N-acetylgalactosamine-6-phosphate deacetylase, GalNAc-6-P deacetylase, N-acetylglucosamine-6-phosphate deacetylase, GlcNAc-6-P deacetylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. NagA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_CORCA
Sequence: VGFKAGVKEYKLTYYTPTYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEANYKSQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGKPPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSGP_ONCMY
Sequence: MIMGGVRELLLVVMTVGVVKVSCYPVGKSQKQDQVSLQRRLGELSSNDVSIVHALALLRSIGSDAKQAREEYLETNEVESQASPNHGSSPANDALSSEEKLRRVSSDDAATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDAMDI
What is the function of this protein?
In response to egg activation, PSGP is discharged by exocytosis into the perivitelline space, where it undergoes rapid proteolysis into glycotridecapeptides.  During fertilization and/or early development the glycotridecapeptides prevent polyspermy or are involved in the formation of a fertilization membrane.
What are the official names of this protein?
Polysialoglycoprotein, PSGP, Apopolysialoglycoprotein, apoPSGP.
Protein: SWNR_METRA
Sequence: MRVAIAGYGDLTRYICEEFVKAGHVLVILTRSYKPQLESQGVAQAITDYSPSSLRAPLADCEVLISTISDISSAYTNVHRNLILACQESPRCKRFIPAEFVADIEAYPDEPGFYYAPHEPIREMLRGQTDLEWTLVCIGWLSDYFVPSKNRHIKDIGEFHPMNWAGNKIVIPGTGNEPVDFTWARDVVRGLASLIEAPRGSWEPYTFMSGERSCWNDATRLAVQKYRPGIPIQHVSLHSVAGMIKTAKDENTEVLADYYLLSISQACAIPTDKVEAHREKYFSGVTFRSLRDGLCQVDEHPDSIL
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of swainsonine (SW), a cytotoxic fungal alkaloid and a potential cancer therapy drug (PubMed:28381497, PubMed:32786262).  Swainsonine production occurs via a multibranched pathway and is dispensable for fungal colonization of plants and infection of insect hosts (PubMed:32786262).  The first step of swainsonine biosynthesis is the production of the precursor pipecolic acid (PA) via conversion of L-lysine (Lys) to 1-piperideine-6-carboxylate (P6C) by the aminotransferase swnA, the latter being further reduced to PA by the reductase swnR (PubMed:32786262).  PA can be converted from lysine by both the SW biosynthetic cluster and the unclustered genes such as lysine cyclodeaminase (PubMed:32786262).  The PKS-NRPS hybrid synthetase swnK uptakes and condensates PA and malonyl-CoA with and without skipping of the ketoreductase (KR) domain in order to produce 3 intermediates, 1-oxoindolizidine, (1S)-1-hydroxyindolizin, and (1R)-1-hydroxyindolizine; with the transisomer (1S)-1-hydroxyindolizin being predominant (PubMed:32786262).  The terminal thioester reductase (TE) domain of swnK is involved in reduction of the thioester bond to release the intermediate aldehydes (PubMed:32786262).  The oxidoreductase swnN could contribute to the reduction of 1-oxoindolizidine to (1S)-1-hydroxyindolizin and (1R)-1-hydroxyindolizine, contributing to the major route of SW production (Probable).  The dioxygenase swnH2 would be responsible for the oxidization of (1R)-1-hydroxyindolizine into (1R,2S)-1,2-dihydroxyindolizine and of (1S)-1-hydroxyindolizin to yield both (1R,2S)-1,2-dihydroxyindolizine and (1S,2S)-1,2-dihydroxyindolizine (PubMed:32786262).  The dioxygenase swnH1 then performs the conversion of the 1,2-dihydroxyindolizine epimers to SW (PubMed:32786262).
What are the official names of this protein?
Oxidoreductase swnR, Swainsonine biosynthesis gene cluster protein R.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: KCNS1_AOTNA
Sequence: MLMLLVRGTRYENHRPKVTLPTPLGGRSNEATVCESPSPDTGIRWRRSDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRVTRPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDHGGTGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEHVGFDTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDGVSEASLETSRETSQEGRSADLETQVPSEPPHSQMY
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
What are the official names of this protein?
Potassium voltage-gated channel subfamily S member 1, Delayed-rectifier K(+) channel alpha subunit 1, Voltage-gated potassium channel subunit Kv9.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.
Protein: ACP_STAA9
Sequence: MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.