PharMolix/UniProtQA huggingface dataset:
Protein: CDC73_CAEEL
Sequence: MDPLEALQKHVQRPEEFPLREVTVSGISYVAFGDYAYKKDTETSLQIYGKSDEFYSLESLVVFLKYSHENHGVYVKEAAAAGVRAVTRIDRKNVTEYLQGDRTDFPALMNQVNPLSLRQLLHSSEPEAKKPRLDGEAAGEPMDTSTSDEPQESAVSAAKKEVEIRALNDNLTKDRIAEMRRKRQSHREKGIVTIDESLSTLTSASLPKTRIHKTRENVMLGARDLSNVLDIITSAQRQWDLNEKKEKVAAVHATNLSKDQSGAAGGQQQRSGYSRYAQEAFAHEKTKEIQTEGSFIGSNFSSIKQGHHAVQKAPDAPPGRPPLAKPIQLLTSSTATSSGSSAAQNGSKRTSRSPIIIVPSAMNTMINLYNVRDILQNFSYVPVDQRRKETNKKPVDLAIQRQKNGVTYNIRVIDNAEKLANDDWDRVIAVFVMGVAWQFKGWKWNGNPTDIFTHIPAFHFHVDQDKPVAQVMQWNVHKIPVSATKRHMDKARFSQVWETIENFVRKNKPHLTARLGL
What is the function of this protein?
Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
What are the official names of this protein?
Cell division cycle protein 73, RNA polymerase-associated protein CDC73.
What is the protein family that this protein belongs to?
Belongs to the CDC73 family.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear localization depends on pafo-1, leo-1 and ctr-9.
Protein: TUS_SHIB3
Sequence: MARYDLVDRLNTTFRQMEQELAAFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVNNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRSLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_VIBVY
Sequence: MGQKVHPNGIRLGIVKPWNATWFANTKDFADNLDGDFKVRQFLTKELSKASLSRIVIERPAKSIRVTIHTARPGVVIGKKGEDVEKLRTAVAKIAGVPAQINIAEVRKPELDAQLVGDSIASQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARSEWYREGRVPLHTLRADIDYATSSAHTTYGVIGIKVWIFKGEILGGMPAATEAAEPKADKPKKQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RPOA_OLIPU
Sequence: MVREKVKVSTRTLQWKCVESRRDSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLRSNLYGTRNALICVQGPGYITARDIILPPSVEIIDNTQHIATLTEPIDLCIELKIERNRGYSLKMSNNFEDRSYPIDAVFMPVQNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALHEASRNLINLFIPFLHVEEETVYLENNQHQVTLPFFPFHNRLVNLRKKKKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKIEHFHIEDVKKILDILEKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OLCB_PENCN
Sequence: MLNLLLLSLSVCLLYVFITAFWNLYIHPLHHIPGPRQWIAFPILRHLSAIRGTLDSDLRRWHFRYGSAVRFGPDEASFITAEAWKDIYGSTRPQLPRVISSGSNTSDIINANDANHARYRKALAHAFSTNGVRDQEPLVIDYIVKLVGRLKEVAESKLPTDMVKWYKLTTFDMIGDLAFGEHFGGLEKSEYHHWVATVGRFTRIIPFLKIMDAYPVLFKVFLAVMPQSFWKAQAEQAEYTKLTVQKRLNSSIAQDRPDFMDSMLRHRNEKDKLSEHELESNASVLVLAGSETPADLLSGVTYWLLKTPEALEKATGEVRSLMKAESEITFSSVEARLPYLLACVNEGLRLYPSLPGELQRMSPDTPMKISGYDIPPRTRVSVHQYAAYSSPTNFHDPDRFIPERWLPEAKTNPSSPYLFDNREVFQPFSVGPRGCIGKSLAYPLMRTIIARVLWNFDFDLCEESRSWHIQKTFGLWEKPPLICKLTQRKQS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of 15-deoxyoxalicine B (PubMed:30090271).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase olcI (PubMed:30090271).  Nicotinyl-CoA is then a substrate of polyketide synthase olcA to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase olcH to yield geranylgeranyl-HPPO (PubMed:30090271).  Geranylgeranyl pyrophosphate is provided by the cluster-specific geranylgeranyl pyrophosphate synthase olcC (PubMed:30090271).  The FAD-dependent monooxygenase olcE catalyzes the epoxidation of geranylgeranyl-HPPO and the terpene cyclase olcD catalyzes the cyclization of the terpenoid component, resulting in the formation of the tricyclic terpene moiety seen in predecaturin E (PubMed:30090271).  The cytochrome P450 monooxygenase then catalyzes the allylic oxidation of predecaturin E, which is followed by spirocylization with concomitant loss of one molecule of water to form decaturin E (PubMed:30090271).  Decaturin E is the substrate of the cytochrome P450 monooxygenase olcJ which hydroxylates it at the C-29 position to form decaturin F (PubMed:30090271).  The short-chain dehydrogenase/reductase olcF may catalyze the oxidation of decaturin F to generate the 29-hydroxyl-27-one intermediate, and subsequent hemiacetal formation probably leads to the formation of decaturin C (Probable).  The dioxygenase olcK may be a peroxisomal enzyme that catalyzes the hydroxylation of decaturin C into decaturin A once decaturin C is shuttled into the peroxisome by the MFS transporter olcL (Probable).  Finally the cytochrome P450 monooxygenase olcB catalyzes the oxidative rearrangement to yield 15-deoxyoxalicine B (PubMed:30090271).  In the absence of olcJ, decaturin E may be shunted to a pathway in which it is oxidized to a ketone, possibly by olcF, to form decaturin D, which undergoes further allylic oxidation to yield decaturin G (PubMed:30090271).  Moreover, in the absence of oclK or oclL, oclB can convert decaturin C into 15-deoxyoxalicine A (PubMed:30090271).
What are the official names of this protein?
Cytochrome P450 monooxygenase olcB, 15-deoxyoxalicine B biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SIAH2_XENLA
Sequence: MSRPSSAGPCASKPCGKQKQPPPPPPHAPSLPATISGGPGASAPPAPTAAAITGPLSQQHQELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRASLTPSIRNLAMEKVASAVLFPCKYASTGCSLSLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLENVMQHLTHSHKSITTLQGEDIVFLATDINLPGAVDWVMMQYCFNHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENYAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Involved in eye morphogenesis, probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:11335112).  May play a role in the regulation of the cellular clock function (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase siah2, RING-type E3 ubiquitin transferase SIAH2, Seven in absentia homolog 2, Xsiah-2.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP306_DROME
Sequence: MSADIVDIGHTGWMPSVQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVEMRHAPDGAVVQD
What is the function of this protein?
Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity.  May be involved in the breakdown of synthetic insecticides.
What are the official names of this protein?
Cytochrome P450 306a1, CYPCCCVIA1, Protein phantom, Dmphm.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: PROF4_PHLPR
Sequence: MSWQAYVDEHLMCEIEGHHLASAAILGHDGTVWAQSADFPQFKPEEITGIMKDFDEPGHLAPTGMFVATAKYMVIQGEPGAVIRGKKGAGGITIKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLLKQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-4, Pollen allergen Phl p 12, pollen profilin variant 1, pollen profilin variant 5.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: P5CS1_ORYSJ
Sequence: MASVDPSRSFVRDVKRVIIKVGTAVVSRQDGRLALGRVGALCEQVKELNSLGYEVILVTSGAVGVGRQRLRYRKLVNSSFADLQKPQMELDGKACAAVGQSGLMALYDMLFNQLDVSSSQLLVTDSDFENPKFREQLTETVESLLDLKVIPIFNENDAISTRKAPYEDSSGIFWDNDSLAGLLALELKADLLILLSDVDGLYSGPPSEPSSKIIHTYIKEKHQQEITFGDKSRVGRGGMTAKVKAAVLASNSGTPVVITSGFENRSILKVLHGEKIGTLFHKNANLWESSKDVSTREMAVAARDCSRHLQNLSSEERKKILLDVADALEANEDLIRSENEADVAAAQVAGYEKPLVARLTIKPGKIASLAKSIRTLANMEDPINQILKKTEVADDLVLEKTSCPLGVLLIVFESRPDALVQIASLAIRSGNGLLLKGGKEAIRSNTILHKVITDAIPRNVGEKLIGLVTTRDEIADLLKLDDVIDLVIPRGSNKLVSQIKASTKIPVLGHADGICHVYIDKSADMDMAKHIVMDAKIDYPAACNAMETLLVHKDLMKSPGLDDILVALKTEGVNIYGGPIAHKALGFPKAVSFHHEYSSMACTVEFVDDVQSAIDHIHRYGSAHTDCIVTTDDKVAETFLRRVDSAAVFHNASTRFSDGARFGLGAEVGISTGRIHARGPVGVEGLLTTRWILRGRGQVVNGDKDVVYTHKSLPLQ
What is the function of this protein?
P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants.  Involved in abiotic stress tolerance.
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate synthase 1, OsP5CS1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
Protein: Y5185_ARATH
Sequence: MGSGLNDTLSRNYNGLELWEIIVIVLSAIFVVVLAISLWLTFRRKTSRSSSNLIPVSRQIPPSVPEEIKEIRVDEVSSSNGGNGYPSISEKFGDKEPEKGIKAESENGDSSRSGSFNHLEKKDGSSVSSANPLTAPSPLSGLPEFSHLGWGHWFTLRDLQMATNQFSRDNIIGDGGYGVVYRGNLVNGTPVAVKKLLNNLGQADKDFRVEVEAIGHVRHKNLVRLLGYCMEGTQRMLVYEYVNNGNLEQWLRGDNQNHEYLTWEARVKILIGTAKALAYLHEAIEPKVVHRDIKSSNILIDDKFNSKISDFGLAKLLGADKSFITTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAITGRYPVDYARPPPEVHLVEWLKMMVQQRRSEEVVDPNLETKPSTSALKRTLLTALRCVDPMSEKRPRMSQVARMLESEEYPIAREDRRRRRSQNGTTRDSDPPRNSTDTDKSEYHDLKPEGG
What are the official names of this protein?
Probable receptor-like protein kinase At5g18500.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CADM4_MOUSE
Sequence: MGRARRFQWPLLLLWAAAAGPGTGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGGDGHKRKEEFFI
What is the function of this protein?
Involved in the cell-cell adhesion.  Has calcium- and magnesium-independent cell-cell adhesion activity.  May have tumor-suppressor activity.
What are the official names of this protein?
Cell adhesion molecule 4, Immunoglobulin superfamily member 4C, IgSF4C, Nectin-like protein 4, NECL-4, TSLC1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CSI1_YEAST
Sequence: MDLLKFSSLAISEINFLHESSFDSIDHSWFLLIGCKLDQDDEIYIPINGNEAESQWYIEKVIRIPMQENDKINQERLERRINLTKVTQKDICILGILDLCQLEEDENITNKVTEKVLTQLTALALKYLIKYNVFRQHTSFQEAVNSLKGYKIENSVQIGAEIILDFLQDKVQIKDVNDRYQIPTPNNTVDPGFDEFQLIDMKDKEINIQKYNNNTIRKLLEKINRMIIFLKNYDATDKPFSSTQDVILRKISMLVTQLQRGGTSDMNYLLDNKINEIKLLEISCKQWEISNMLKK
What is the function of this protein?
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response.
What are the official names of this protein?
Cop9 signalosome-interactor 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NORR_SALTI
Sequence: MSFSVEVLAGIAIELQRGIGHQDRFQRLITTLRQVLACDASALLRYESRQFIPLAIDGLAQDVLGRRFTLEGHPRLEAIARAGDVVRFPADSDLPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDAMTPEQFEVFSDEELRLVAALAAGALSNALLIEQLESQNMLPGSSGVFEPIKETHMIGLSPAMTQLKKEIEIVAGSDLNVLIGGETGTGKELVAKAIHQGSPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLFVPPLRERGDDVVLLAGYFCEQCRLRLGLSRVVLSPGARRHLLNYGWPGNVRELEHAIHRAVVLARATRAGDEVVLEEQHFALSEDVLPAPSAESFLALPACRNLRESTENFQREMIRQALAQNNHNWAASARALETDVANLHRLAKRLGLKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: AIP9_SCOMU
Sequence: MCKYFIKIVSKSAKK
What is the function of this protein?
Anti-inflammatory peptide.  By activating the G-protein coupled receptor formyl peptide receptor 2 (FPR2), this peptide markedly activates neutrophils, resulting in cytosolic calcium increase, superoxide anion production, and chemotactic cellular migration.  In vivo, when tested on a auto-antibody-injected model, its administration strongly blocks the clinical phenotype of rheumatoid arthritis (RA).  Mechanistically, this peptide inhibits inflammatory cytokine synthesis from the joints and neutrophil recruitment into the joint area.  It may serve as a novel potential therapeutic agent for the control of RA via FPR2.
What are the official names of this protein?
Scolopendrasin-9, Scolopendrasin IX.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMH_ECOLC
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYN1_GEOSE
Sequence: MRNVVRKPLTIGLALTLLLPMGMTATSAKNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADRIVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEVVGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIGWPSEAEIEKTINMFAALGLDNQITELDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIADNHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
What are the official names of this protein?
Endo-1,4-beta-xylanase, Xylanase, 1,4-beta-D-xylan xylanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DRC2_RAT
Sequence: MPKKGKKPKLPLTDEEQLILFQQKLLADEEAAKKKERLLTQFLKDKLAKEEHNSSLNLNKINTQWRTVLREVKTRELHKDIEILSQIFERVVDCKDSVIKSLARDLTEAEEQYAHALRGHLHNVDQLLTLQRRRLSLLEENYNMELEVLTKEFETERKAILDHHDKEIHYLHDVFMAMEQNYVDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENVVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSKEIEVQMKKIQRLQEAISALKGKIVAHSREGEWQNQCIRNDKELVHVQLRKLKIQRTQARTESQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSALTPEEQEEVEIQSQEEITEDLAKIMMDYLGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSRLNPLFIVNHKSNLPQLPPSAAQPGGDRGPGGDRRLTYNVIEAAHIASHIL
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.  Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes.  Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
What are the official names of this protein?
Dynein regulatory complex subunit 2, Coiled-coil domain-containing protein 65.
What is the protein family that this protein belongs to?
Belongs to the DRC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: HMT1_MAIZE
Sequence: MGVLEDLVARAGGCAVIDGGFATQLEALGADINDPLWSAACLITRPHLVKEVHMQYLEAGADVIISSSYQATIPGFIARGMSVAEAEDLLRTSVKLANEARDEFWKSTLRKSKPIYNRALVAASIGSYGAYLADGSEYSGSYGADITAEKLKDFHRRRLQVLASAGPDLIAFEAIPNQMEAQALVELLEEEKVQIPSWICFSSVDGKNLCSGESFADCLKILNASEKVAVVGVNCTPPQFIEGIICEFRKQTKKAIAVYPNSGEVWDGRAKRWLPVECLGHKSFDALAKRWQEAGASLIGGCCRTTPSTIRAVSKILKGRTGH
What is the function of this protein?
Catalyzes methyl transfer from S-methylmethionine (SMM) to adenosyl-L-homocysteine (AdoMet).  SMM degradation (by HMT-1, HMT-2, HMT-3 and HMT-4) and biosynthesis (by MMT1) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level (By similarity).
What are the official names of this protein?
Homocysteine S-methyltransferase 1, S-methylmethionine:homocysteine methyltransferase 1, SMM:Hcy S-methyltransferase 1, ZmHMT-1.
Protein: MAPK3_HUMAN
Sequence: MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
What is the function of this protein?
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation.  Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.  Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.  MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2.  Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.  Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively.  Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.  Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript.  Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.  Also acts as a modulator of Polycomb-mediated repression.
What are the official names of this protein?
MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP-K3, MAPKAPK-3, MK-3, Chromosome 3p kinase, 3pK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Protein: NU4LM_HYDLE
Sequence: MTMVYANIFLAFITSLMGLLMYRSHLMSSLLCLEGMMLSLFVMMTVTILNNHFTLASMTPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYGB_AROAE
Sequence: MMTTATVLVELLTEELPPKALPRLGETFAAKVFEGLKARDLVAEDRGFRCFAAPRRLAVTVPTVRAAAPSREVTEKIMPVQVALDAEGRPTPALLKKLQAKGIAPEAVASFERRVDGKAEALFYTHLEPGAALDDVLAAIVQEAVKALPIPKLMRWGAGDAQFVRPVHKLAMLHGARVVPGRVLDLDAGRVTMGHRFMSRGEIELATAEAYEPTLLAEGKVIPDFAERRSNIERQLVATAQEQGASLGEYADLLDEVAALVEHPTVYVGEFELEFLAVPQECLILTMRANQKYFPLFDAAGKLLNRFLIVSNMRLADPSNIVAGNQRVVRPRLSDARFFFEQDRKHTLDSRLPRLAPVVYHNKLGSQLERVERLERLAGRIADRLHGDVAAASRAARLAKADLVTDMVGEFPELQGIMGRYYALNDGEGEVVADAVQSHYQPRFAGDTLPAGNTACAVALADKLDTLVGFFGIGQLPTGDKDPFGLRRAALGVLRILIETPLPLDLAALVGDAAEGFAPGLLTAADFESQLLDFMFERLRNLLREAGHAVDVVDAVLALHPTRIDLVPAKLDAVRVFRGLPEAEALAAANKRIVNILKKAEDELPEPDVALLQEQAEKALFHAVVEVAPLVHSHVANEDYTDALCALAGLRAAVDTFFDDVMVMVEEPLTRRNRLALLRQLAGLMNQVADLSRLSA
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPS_SHIFL
Sequence: MVKSQPILRYILRGIPAIAVAVLLSACSANNTAKNMHPETRAVGSETSSLQASQDEFENLVRNVDVKSRIMDQYADWKGVRYRLGGSTKKGIDCSGFVQRTFREQFGLELPRSTYEQQEMGKSVSRSNLRTGDLVLFRAGSTGRHVGIYIGNNQFVHASTSSGVIISSMNEPYWKKRYNEARRVLSRS
What is the function of this protein?
A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links.  Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion.  Functionally redundant with MepM and MepH.  Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds (By similarity).
What are the official names of this protein?
Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase, Lipoprotein Spr, Murein hydrolase MepS.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.