PharMolix/UniProtQA huggingface dataset:
Protein: METK2_DAUCA
Sequence: MDTFLNTSESVNEGHPDKLCDQISDAVLDACLEQDPDSKVACETCSKTNMVMVFGEITTKANVDYEKIVRKTCRDIGFVSDDVGLDADNCKVLVQIEQQSPDIAQGVHGHLTKRPEDIGAGDQGHMFGYATDETPELMPLSHVLATKLGAKLTEVRKNGTCPWLRPDGKTQVTVEYYNDKGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPIIPAKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRMIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVSYAIGVPDPLSVFVDSYGTGNIPDKEILKIVKETFDFRPGMIAINLDLKRGGNNRFLKTAAYGHFGRDDADFTWEVVKPLKWEKPQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_METI4
Sequence: MRHQKRTHKLGRDTQHRSALIANLAKELIEHKRIKTTLIKAKALRPFAEKLITLAKKGTLHARRLVVRKIHSKKAARLLFKEIAPQMQGRIGGYVRIYKMGNRLSDGAKMALIEWTEGQVPVENQKAQKAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SYY_NITWN
Sequence: MVAFKSDFLNTLQERGFIHQCSDFEGLDALASRNQVTAYTGYDCTAPSLHVGHLLSIMMMHWLQQTGNKPIALMGGGTTRVGDPSGRDETRKILSYDQIDANKESIKGTFLKFLVFGDGKNDAIMTDNAEWLTRLNYIEMLRDVGRHFSINRMLTMDSVKMRLEREQELSFIEFNYMILQSYDYVELARRHGCNLQMGGSDQWGNIVNGVDLGRRMGTHQLYALTCPLLTTSSGAKMGKTAAGAVWLNATMLPVYDYWQYWRNVEDADVGRFLKLFTILPMGEIAKLAALQGSEINEAKKVLATEATALLHGRDEAEKAADTARTTFEQGAISESLPTLDIPRSELASGAGVLALFVKAGLVASNGEARRQIKGGGLRVNDVAVADDKMVLTPDHLTPEGVIKLSMGKKRHVLLRPA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTR24_ARATH
Sequence: MAITYSSADELGNTTEGFLEIRENTSGGWKSARLIIVVQMAERFAYFGIASNLIMYLTGPLGESTAAAAANVNAWTGTVAFLPLLGGFLADSYLGRFRTIIISSSLYILGLGLLSFSTMIPSHQSKDSNQLQETIFFFSLYLVAIGQGGYNPCIKVFGADQFDGNDHKEARDKSSFFNWLMFGNCISILTTRLVSTYIQENLSWSLGFGIPSVSMLLSLFLFLLGTTSYRFSTERVGKKNPFARISRVFMEALKNRRQPDLDIANANANETLLLLAHQSSKQFRFLDRAAISCELAEIEEAKAVLRLIPIWITSVVYTIVHAQSPTFFTKQGATMDRSISPGLLVPAATLQSFINLSVVVFIPIYDRLLVPFARSFTQNSSGITTLQRIGTGIFLSILAMVLAALVETKRLQAARDELSIPMSVWWLIPQYVIFGVSDMFTMVGLQEFFYGQVPSELRSVGMALNLSIYGAGNYLSSFMISVIDKITNQYGQRSWFDNDLDQAHLDYFYWLLACLGFIGFAFYLWFAKSYVYSRSNTF
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 5.11, AtNPF5.11.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CB2B_PINSY
Sequence: MASCGIGSCAFAGGQISSLKPHTNQLLGVGAGVHGEARVTMRKATTKKLTASASTSPWYGPDRVLYLGPFSGEPPSYLTGEFPGDYGWDTAGLSADPENFAKNRELEVIHCRWAMLGALGCVFPELLARNGVKFGEAVWFKAGAQIFSEGGLDYLGNPSLVHAQSILAIWACQVILMGAVEGYRIAGGPLGEVTDPIYPGGSFDPLGLAEDPEAFAELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPIENLADHLADPVNNNAWAYATNFVPGK
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein type 2 member 1B, chloroplastic, Chlorophyll a-b binding protein type II 1B, CAB, LHCP.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: HSP7F_SCHPO
Sequence: MSSRTNVVGIDFGNSKTVIAVARNRAIDVIVNEVSNRSTPSLVSYGERSRFLGEAAKSAEASNFRNTVGSLKRLAGRTYDDPEIKDIESNFISAKLTEVDGFVGAKVQYLNEETAFSNIQLIAAYFTKIKAIAEAELIGSVSDVVISIPAWFTDIQRRALLEAANIAGLNPLRLMNDNAAAALTYGITKTDLPEPESPRRVAIVDFGHSNYSVSIVEFSRGQFHIKSTVCDRNLGSRNMDKALIDYFAAEFKEKYKIDVLSNPKATFRLATAVERLKKVLSANANAPLNVEMIMNDIDASSFIKRSDFEELIKPLLERLTPPIEKALELAGIKKEDLYSIEMVGGCTRVPIVKEVIANYFGKGLSFTLNQDEAVARGCALSCAILSPVFRVREFHVHDVTTYPITFSWEPIPENPEEDSSLEVFSEGNPIPSTKILTFYRKAPFKLLAAYSKEAQLPGSIKQNIAQYLINDVVPNKDGDLSIVKIKVRLDLHGILVVEQAYIVEEQEVEEPVETSPEEEAEKKTDEPVKMRKVKKLVKVADLSVSVQEDRLPTEVLEKYREAEHQMIATDKLVAETVDRKNALEEYIYDTRAKLDDIYAPFTNEEESSKFKEMLTKAEDWLYEEGEDTTKAVYTAKLEDLMRVGGPIRQRYLDAEEAKRQKVQAEREAAKAATKSEAEKQKPSGKFEEGTGGRAPPPPPAEEVAPENEEVETMEIDEQKE
What is the function of this protein?
Required for normal growth at various temperatures.
What are the official names of this protein?
Heat shock protein homolog pss1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E1B55_ADEM1
Sequence: MEDRQALEEAGEEMGFPVVNISGGGRGRRGNYSNDGSGARELSLRVNEEVTEPPYNSITYAEVLRLYRQNGFSFFLSNLHFEQIKYFEHREGEGDLGAIIREHGKIVLDPNVVYHLRRPLKIQSLCYIVGRGAVIKVHASVGQQAVHVYRQLDISPRIMGMLNVTFLECKFHWADDEGVNFERLARHFTLFFLTYESVFFACDFVGFPGLTLRSTCLLRVEGCTFTSCAVGIHHADVADLKVKACYFNHCSVCIFADGPADVLRNCATNCDCFVIMEQEGSVVGNSVVYKLPPSRADDLMICQQGYMYPLSSIHIVRNLSCEYPKLKNNVFSHVDMHVGLRQGLQHFNQCNLSFVYCMLETESVPKVSFYSSYIQTLTVAQIVQFSREHSRECQCFCGGRHRLLFPSVVHITPTVVPDRTRFTVDVEELSDDE
What is the function of this protein?
Plays a major role to prevent cellular inhibition of viral genome replication.  Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.  This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM.  Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.  E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain.  E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
What are the official names of this protein?
E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 55 kDa protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53.
Protein: RS15_ACIET
Sequence: MIASSVKAEVVKANARSANDTGSPEVQVALLTARINELTPHFKQHAKDHHGRRGLLRMVSRRRKLLDYLKAKDADRYTALIAKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ARCA_VIBVU
Sequence: MSKLYVGSEVGQLRRVLLNRPERALTHLTPSNCHELLFDDVLLVEAAGKEHDAFADTLRQQGVEVLLLHDLMVDTLAVPEAKQWLLDVQISDFRYGPIFARDLRRYLSEMDNEHLATILLGGLAYSELPIQSASMLPRMKQPLDFVIEPLPNHLFTRDTSCWVYGGVSLNPMMKPARQRETNHLRAIYQWHPIFAGQDFIKYFGNEDLHYDNANIEGGDVLVIGKGAVLIGMSERTTPQGVENLAANLFKHGQAKEVIAIELPKHRSCMHLDTVMTHMDVDTFSVYPEIMRKDLHTWRLTPKGNGEMQVEALHNYLHAIERALGLNHLNIITTGGDSYEAEREQWNDANNVLTVKPGVVIGYERNVYTNEKYDKAGIEVLTIPGNELGRGRGGARCMSCPIERDDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLXK1_ECOLI
Sequence: MKIVIAPDSYKESLSASEVAQAIEKGFREIFPDAQYVSVPVADGGEGTVEAMIAATQGAERHAWVTGPLGEKVNASWGISGDGKTAFIEMAAASGLELVPAEKRDPLVTTSRGTGELILQALESGATNIIIGIGGSATNDGGAGMVQALGAKLCDANGNEIGFGGGSLNTLNDIDISGLDPRLKDCVIRVACDVTNPLVGDNGASRIFGPQKGASEAMIVELDNNLSHYAEVIKKALHVDVKDVPGAGAAGGMGAALMAFLGAELKSGIEIVTTALNLEEHIHDCTLVITGEGRIDSQSIHGKVPIGVANVAKKYHKPVIGIAGSLTDDVGVVHQHGIDAVFSVLTSIGTLDEAFRGAYDNICRASRNIAATLAIGMRNAG
What is the function of this protein?
Catalyzes the transfer of the phosphate group from adenosine triphosphate (ATP) to (R)-glycerate to form (2R)-2-phosphoglycerate, an enzymatic step in (L)-glucarate/galactarate catabolic pathway.
What are the official names of this protein?
Glycerate 2-kinase, Glycerate kinase 1, GK1.
What is the protein family that this protein belongs to?
Belongs to the glycerate kinase type-1 family.
Protein: MURE_CHLPD
Sequence: MSLADLIRQIPVLEAAGGSTTSLPVSMISSDSRDVLPGALFIAVRGYSADGHRFIKSAVERGAAAVLCEEIPPVLPDASLPYLRVEDARQALALAARQFYGFASDALHVIGVTGTNGKTTTARLITAMLNACGIRTGYIGTNLCTFGEQQIPLDRTTPEAHILHALFRRMLDSGCSVAVMEVSSHALVLQRVYGITFHAAVFTNLSMEHLDFHKTMQEYAGAKRQLFEQLSPQGFAVINSDDPRAEEMVSKINPEKRFCCTLDQTGRVAGDASRRFSAELIDQSIASATIRLCFPDAQQTISTVLPGQYNVMNLLQAAAVGCGMGLGSPVVAAALDALPGVAGRMERIMDRRRKEFVFVDYAHTPDALFKALSTLNALKSPASRLIVVFGCGGNRDRLKRPEMGRIAVENADLVILTSDNPRDEDPEMIIDEIEKGIRVKNHKRITDRAQAIRTAVALLQPGDVLLVAGKGHEQYQETAGEKSFFSDQETLRNALAEENAGEPEKGAVCKGC
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRTSO_SOLLC
Sequence: MCTLSFMYPNSLLDGTCKTVALGDSKPRYNKQRSSCFDPLIIGNCTDQQQLCGLSWGVDKAKGRRGGTVSNLKAVVDVDKRVESYGSSDVEGNESGSYDAIVIGSGIGGLVAATQLAVKGAKVLVLEKYVIPGGSSGFYERDGYKFDVGSSVMFGFSDKGNLNLITQALAAVGRKLEVIPDPTTVHFHLPNDLSVRIHREYDDFIEELVSKFPHEKEGIIKFYSECWKIFNSLNSLELKSLEEPIYLFGQFFKKPLECLTLAYYLPQNAGSIARKYIRDPGLLSFIDAECFIVSTVNALQTPMINASMVLCDRHFGGINYPVGGVGEIAKSLAKGLDDHGSQILYRANVTSIILDNGKAVGVKLSDGRKFYAKTIVSNATRWDTFGKLLKAENLPKEEENFQKAYVKAPSFLSIHMGVKADVLPPDTDCHHFVLEDDWTNLEKPYGSIFLSIPTVLDSSLAPEGHHILHIFTTSSIEDWEGLSPKDYEAKKEVVAERIISRLEKTLFPGLKSSILFKEVGTPKTHRRYLARDSGTYGPMPRGTPKGLLGMPFNTTAIDGLYCVGDSCFPGQGVIAVAFSGVMCAHRVAADLGFEKKSDVLDSALLRLLGWLRTLA
What is the function of this protein?
Carotene cis-trans-isomerase that converts 7,9,9'-tri-cis-neurosporene to 9'-cis-neurosporene and 7,9,9',7'-tetra-cis-lycopene (also known as prolycopene) into all-trans-lycopene.  Isomerization requires redox-active components, suggesting that isomerization is achieved by a reversible redox reaction acting at specific double bonds.  Isomerizes adjacent cis-double bonds at C7 and C9 pairwise into the trans-configuration, but is incapable of isomerizing single cis-double bonds at C9 and C9'.
What are the official names of this protein?
Prolycopene isomerase, chloroplastic, CrtISO, Carotenoid isomerase, Protein tangerine.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Peripheral membrane protein.
Protein: BRAC_ANNTR
Sequence: MASLYLPTIWASTLTAATIFIVAVLSKWLRKPRSFDVPIVGAESGDLNVLKARYVQEADALLREGYEKFKDAIFQVITPDGPRVFLPRKYAHDLKDYSRHEASGMKALADRHIGHYTTIDHESDIMLGAIKIDLNRNLGTFVGDVEHEVAFCFETQFPACDDWTPIDLHDKLLRVVAQASARIFVGYPMCRNEEWLECSTKFALDVMTGGEKLKQWHPYLRPIAQYFVPEMTRIRGDHQRALELLLPELNRRLAEPADPDSSPHNDMIQWMQDRARKTGDNSFDNKELANLQMLTATAAIHTTRLAIIHALYDLAARPEYVEPLRKEILEATKDSNGVLQKQHLTQMKMLDSFMKESQRHSPPSVATYQRKAMIPITLSNGFHIPAGTIVQCNTNILDETPPDWGDPHAFDGFRFYKLRNRTPDDINKFQFASPTYDSMQFGFGKDACPGRFFASNQIKIILAYILSHYDIKFEDSVVGRPKNFMFEVNVLADPTKMVLFKKIR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the brasilane terpene glycosides brasilane D and E (PubMed:32936132).  The biosynthesis starts with the activity of the terpene cyclase braA that converts farnesyl pyrophosphate into the sesquiterpene alcohol trichobrasilenol (PubMed:32936132).  Subsequently, trichobrasilenol is glycosylated by the O-glycosyltransferase braB putatively using UDP-GlcNAc as sugar donor to yield brasilane A (PubMed:32936132).  The latter then undergoes two rounds of oxidation performed by the cytochrome P450 monooxygenase braC (PubMed:32936132).  In the first round braC hydroxylates C-12 forming brasilane D, which serves as substrate in the second round to establish the epoxide at the bond between C-5 and C-10 and oxidize the alcohol at C-12 to an aldehyde leading to the final product brasilane E (PubMed:32936132).
What are the official names of this protein?
Cytochrome P450 monooxygenase braC, Brasilane terpene glycosides biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y057_NPVAC
Sequence: MKHPVYARYLEFDDVVLDLTSLIFLEFDNAQNEEYIIFMNVKKAFYKNFHITCDLSLETLTVLVYEKARLIVKQMEFEQPPNFVNFISFNATDNDNSMIIDLCSDARIIVAKKLTPDETYHQRVSGFLDFQKRNCIPRPPIESDPKVRDALDRELEIKLYK
What are the official names of this protein?
Uncharacterized 19.0 kDa protein in LEF8-FP intergenic region.
Protein: RSMJ_SERP5
Sequence: MSVCLLCEEGADPGALSILAQRWQLTSDDEALMALVLTPERLELRKRDEPKLGAIYVDFVSGTMAHRRKFGGGRGEAVAKAVGIKGNYRPDVVDATAGLGRDAFVLASLGCRVRMLERNPVVAALLDDGLQRGYQDAEIGPWLRERMTLLHASSLTALGDIDPRPEVVYLDPMYPHKQKSALVKKEMRVFQSLVGSDDDADGLLEPARRLATKRVVVKRPDYAPPLANVQAHAASTTKSHRFDIYMPV
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_PSYWF
Sequence: MIDPKLLRQDLTELKQKLAKRGYELDVDFWQQMESQRKSLQVITEDLQAKRNAGAKQVGVLKKNGEDATELLAEMQNISSEMKQAEESLKALQDKINQAALQIPNIPADDVPEGSSEEDNVEVRKWGTPRQFDFKVQEHSDLGEVLGQLDFAAAAKLTGSRFSVLKGQLAQLHRALIQFMLNTHTVKYGYTECYVPYIVNSDSLEGTGQLPKFEEDLFKLTNHTNNEAMGFYLIPTAEVPMTNLVRGERLDASELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAAQSDELLEQMTGQAEYILQQLQLPYRVVKLCTGDMGFSALRTYDIEVWVPSQDTYREISSCSNCGDFQARRMGTRVKEGKKTELVHTLNGSGLAVGRTLLAIMENHQNADGSITIPEVLRPYMGGAEIISA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD69_DANRE
Sequence: MGCHNSKVCGQVSKKKKKNKAQEGEKRTKDIKLQDGRGTHSSEEERCCLENQLENYEWQLKILHAVLTASGDQEREQLLKDHPGDICTLVHSITEKVKTEISADLNDLHEQQMRSVSEQHQSETEELQRLHSEEKNVLNESHAAAEEALKDQIEDLTSELKLFNELKRRAEASTLKRDLQRNIETHGSPGEFWEQEQESLLFVIEMKRQNLQDQGNKLLQMEAQVEKNLSLEDQLLQALQQNEDFRVRIENYQSLIQQLSKEQNDMQEVLEKQSLQNQKLIQEKEELLFKLLHRRDSCSTFHLPSVIPTQVSPS
What is the function of this protein?
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.
What are the official names of this protein?
Coiled-coil domain-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the CCDC69 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.
Protein: YIHY_ECO27
Sequence: MLKTIQDKAKHRTRPLWAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLVAVVFALFAAFPMFSDVSIQLRHFIFANFLPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYSIDSALNTIWRSKRARPKIYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRIFPLLLSWISFWLLYSIVPTIRVPNRDAIVGAFVAALLFEAGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEDDEP
What are the official names of this protein?
UPF0761 membrane protein YihY.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PON1B_ANOEM
Sequence: RYCPSGCRKKPYGGGCSC
What are the official names of this protein?
U1-poneritoxin-Ae1b, U1-PONTX-Ae1b, Poneratoxin.
What is the protein family that this protein belongs to?
Belongs to the poneritoxin-Ae1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENV_BLVAF
Sequence: MPKKRRSRRRPQPIIRWVSLTLTLLALCRPIQTWRCSLSLGNQQWMTAYNQEAKFSISIDQILEAHNQSPFCAKSPRYTLDSVNGYPKIYWPPPQGRRRFGARAMVTYDCEPRCPYVGADRFDCPHWDNASQADQGSFYVNHQILFLHLKQCHGIFTLTWEIWGYDPLITFSLHKIPDPPQPDFPQLNSDWVPSVRSWALLLNQTARAFPDCAICWEPSPPWAPEILVYNKTISSSGPGLALPDAQIFWVNTSSFNTTQGWHHPSQRLLFNVSQGNALLLPPISLVNLSTASSAPPTRVRRSPVAALTLGLALSVGLTGINVAVSALSHQRLTSLIHVLEQDQQRLITAINQTHYNLLNVASVVAQNRRGLDWLYIRLGFQSLCPTINEPCCFLRIQNDSIIRLGDLQPLSQRVSTDWQWPWNWDLGLTAWVRETIHSVLSLFLLALFLLFLAPCLIKCLTSRLLKLLRQAPHFPEISLTPKPDSDYQALLPSAPEIYSHLSPVKPDYINLRPCP
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: WBJC_PSEA1
Sequence: MKVLVTGANGFVGRNLCAHLAERGGIEVVPFTRESSVGNLPELIRSVDFIFHLAGVNRPEKPEEFKIGNSELTYALCEAVRSNGRAIPLLYTSSIQAEVDNEYGLSKRAAEEHLQVLGEDIGCPVYIFRLPNVFGKWSRPNYNSAVATFCHNIIRDIPIQINNSSAEITLVYIDDVVRTFMKVMDGKLSNAVSLQVEPQYQISVGELAEQLYEFRNSRKSLTTARVGSGLTRALYSTYLSFLPEDSFSYDVPMHSDPRGTFVEMLKTADSGQFSFFTAHPGVTRGGHYHHSKTEKFLVIKGMARFKFRNILTGAFYEICTNGEKAEIVETVPGWTHDITNVGTDDMVVMLWANEVFDRENPDTYACSVGEGA
What is the function of this protein?
Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis, thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen.
What are the official names of this protein?
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: YAF1_BACLI
Sequence: MRTGGLREMSQTNEYEVFQKEIKEIKADQKTLEKRVSTLERTSERHDQQIISINEKLNKIEENTTWIKRSITGAIITAVSTGIIGGAIAVFYNLLQK
What are the official names of this protein?
Uncharacterized 11.0 kDa protein in cwlL 5'region.
What is the protein family that this protein belongs to?
To B.licheniformis xpaL1 and to B.subtilis XhlA.
Protein: MSHR_CANLF
Sequence: MVWQGPQRRLLGSLNGTSPATPHFELAANQTGPRCLEVSIPNGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAGALAAQAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQHARGIARLRKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHPICGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RAB5A_PIG
Sequence: MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGINCTRGRGVDLTEPTQPTRSQCCSN
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  RAB5A is required for the fusion of plasma membranes and early endosomes.  Contributes to the regulation of filopodia extension.  Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan.  Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
What are the official names of this protein?
Ras-related protein Rab-5A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle. Membrane. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane. Endosome membrane. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.
Protein: YJS2_YEAST
Sequence: MTGYRVIHLTGIYYTFYRRKSFFFFFLEYLHNSLRVLSWKGIITKIAASPFVIVLYFNTAFFNPFKTLYENEKKKAKKNLKLTRENASLSIRKMHQYSAIIPSGT
What are the official names of this protein?
Putative uncharacterized protein YJL182C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.