PharMolix/UniProtQA huggingface dataset:
Protein: CP19A_CHICK
Sequence: MIPETLNPLNYFTSLVPDLMPVATVPIIILICFLFLIWNHEETSSIPGPGYCMGIGPLISHGRFLWMGVGNACNYYNKTYGEFVRVWISGEETFIISKSSSVFHVMKHWNYVSRFGSKLGLQCIGMYENGIIFNNNPAHWKEIRPFFTKALSGPGLVRMIAICVESTIVHLDKLEEVTTEVGNVNVLNLMRRIMLDTSNKLFLGVPLDESAIVLKIQNYFDAWQALLLKPDIFFKISWLCKKYEEAAKDLKGAMEILIEQKRQKLSTVEKLDEHMDFASQLIFAQNRGDLTAENVNQCVLEMMIAAPDTLSVTLFIMLILIADDPTVEEKMMREIETVMGDREVQSDDMPNLKIVENFIYESMRYQPVVDLIMRKALQDDVIDGYPVKKGTNIILNIGRMHKLEFFPKPNEFSLENFEKNVPSRYFQPFGFGPRGCVGKFIAMVMMKAILVTLLRRCRVQTMKGRGLNNIQKNNDLSMHPIERQPLLEMVFTQEAQTRIRVTKVDQH
What is the function of this protein?
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
What are the official names of this protein?
Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: RUVB_LAWIP
Sequence: MSETAGKGVTMPEIMQSSYPDETLYREKDDSIRPSRLDDFIGQEELRENLKVFLNAARDRGQAMDHTLFYGNPGLGKTTLAQIIAAELGVNLICTSGPVLERSGDLAAILTNLSKHDILFVDEIHRMPITVEEILYPALEDYKLDLVIGQGPAARTVKIELEPFTLVGATTRIGLISSPLRDRFGIISRLEFYTPEELSQIILRTSRILNVPITKKGAIEIGRRSRGTPRIANRLLRRVRDFAAVFGSATVDEELVNHALQKLDVDEKGLDQMDRKLLTVLIELFAGGPVGIKTLAVACSEEVRTIEDIYEPYLIQCGFMKRTPRGRMATVKAYKHLNLTD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ATPG_BARHE
Sequence: MASLKDLRDRIASVKATQKITKAMQMVAAARLHRAQEAAHSARPYAKRMAAILANLANDVDPIDAPSLMRGTGRDDVHLLVVCTAERGLCGAFNVQIARRAREHIKTLLAAGKIVKVLTVGKKGADILSRDYKALMIDHIDLQSIKRVGFAEAAMISQKIVDLFDDDAFDVCTLFYSEFVSVINQRPVAFGLVPMVSSGGAVETAEVEQKIDNSADLQSIVYDYEPDAASLLDVLVPRNLSVQIFRALLENVAGEMGAKMTAMDNASRNAGEMINKLTVAYNRQRQAQITTELIEIIAGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PCHTP_TRISP
Sequence: MAFSTIVVLFVAAVGFGNKISSADTCPEFGEWKPWTECLWYPMQNIYDKMTASCGLPGHRNLTNILPLPPGFTIPPPCGHCSFKTRCRTRPKKEGCYPFDGEREICHEHGDICTIAKLPGIGCGWTVLQEVVKQCLSRPDIPEYMRAGYKKLFHMLPKGHCIEKDNQCKCCCGDYEPNEDGTECVKQQDHQCAPFNEPGDWSECLWFPLADMFKKVQSHCGVEGKPEGLSPSSLAPAGFQIPEKCGFCSFRLKCQSREKKEGCFPLKVDKKSCGAEDCPTCGDVCTLDKQNNSCAFTKAMGMKFWNSFAHKAKESNLAHWRRDGYADLFKFLPYGHCKEVGDKCKCCCHPYEPNEDGTACVVKQYCKSLEEVGGKKQQKDQPESEKKAENMPETTGNASHHQHRHHHGDSSSESHEQHHHHHHH
What is the function of this protein?
Binds iron and zinc.  May bind nickel.
What are the official names of this protein?
Poly-cysteine and histidine-tailed protein, Ts-PCHTP.
Protein: YBEY_MACCJ
Sequence: MLTVDFIDDNAQIDAKHLPEIERLLIFAAEQEGIDEEAEVAVSFVDENEIQAINKAYRNKDAVTDVISFALEEGEDDFEMSDEPRVLGDIIICVKRALEQAEEYGHSFERELGFLSLHGLLHLLGYDHMNESDEARMFGRQDEILNAFGLRRDV
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1985_PYRAR
Sequence: MKVEVVVEVRHTENKQKVIHALENIFTPKKIEEKRSDVGTVLIASCEGHECLEKLRSAIWRQGIQDAARSVIARGIVAEDTVVFSVNKQAAYAGVVSFVTEPNESPLGPITFTVKTSNTRQFLDWIAPRTYRGRVYYQAPPPD
What are the official names of this protein?
UPF0201 protein Pars_1985.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: AZOR_LACP7
Sequence: MSKVLYIKANIKLEGVSRTFQVSDHFIEEYKKQHPEDEVVVLDLYKENIDFLRPEDLEAMADINDETKKNTTFLKYAFQFAEADKYVIAAPMWNLGSPAILKAYFDYITITGITFHYTAEGPKGLLQNKKAVHIVARGGEYGNAPYEMGDRYVKTILGFLGVSDIQTIAIENLDIIGADVEAKVKEGKEKAGLVAKEF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RISB_STAES
Sequence: MNFEGKLVGKDLKIAIVVSRFNDFITTRLLEGAKDTLIRHEVEDTNIDVAYVPGAFEIPLVAKKLAQKGEYDAVITLGCVIRGATSHYDYVCNEVAKGVSKANDISDTPVIFGVLTTESIEQAVERAGTKAGNKGSEAAVSAIEMANLIKQIN
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RPOA_STAA3
Sequence: MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: HEM2_SCHPO
Sequence: MPVDISSLLHAGYSNPLLREWQGVRPITKSSLMYPIFISEIDDAKEAIDSMPNQFRWGVNRLEEFLGPLVKKGLRSVILFGVIESKKDYCGSMADSENGPVIKAVKEIRHLFPELVVACDVCLCEYTDHGHCGLLYEDGTINNAKSVERIAEVSGNYALAGAQIISPSDCMDGRVKAIKQKLVELELSHKVCVISYSAKFASGFFGPFRAAANGAPKFGDRSCYQLPCNARGLAKRAILRDVREGADGIMVKPGTPYLDILAMASKLADDLPIATYQVSGEFAIIHAAAAAGVFELKRHVMETMDGFMRAGANIVLTYFTPELLEWLEY
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: HBB_ERIEU
Sequence: VHLTAEEKALVTGLWGKVKVEEFGGEALGRLLVVYPWTQRFFDSFGDLSSADAVMGNPKVKAHGAKVLQSMGDGIKNLDNLKGTFSKLSELHCDKLHVDPENFRLLGNVLVCVLARHFGKDFTPAAQAAFQKVVAGVANALAAKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DAT_ACIBA
Sequence: MSVTSVNPATNATNEYYLTRQSQMESNVRSYPRKLPLAIAKAQGCWVTDVEGTQYLDCLAGAGTLALGHNHPAVIQSIQDTLASGLPLHTLDLTTPLKDAFTEALLAYLPGGKEEYCLQFCGPSGADATEAAIKLAKTYTGRSSVISFSGGYHGMTHGSLAMTGNLSAKNAVNGLMPGVQFMPYPHEYRCPLGLGGEAGVDALTYYFENFIEDVESGVTKPAAVILEAIQGEGGVVTAPVKWLQKIREVTEKHNIVLILDEVQAGFARSGKMFAFEHAGIEPDVVVMSKAVGGGLPLAVLGIKRKFDAWQPAGHTGTFRGNQLAMGTGLVVLETIKEQNLAQNAQERGEFPCIGNVRGRGLMIGVEIVDERKPADRIGSHPADSQLAAAIQTACFNNNLLLEKGGRNGTVIRLLCPLIITQEECVEVIARFKKAVAEALVAVRGA
What are the official names of this protein?
Diaminobutyrate--2-oxoglutarate aminotransferase, Diaminobutyrate transaminase, L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, DABA aminotransferase, DABA-AT, L-diaminobutyric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: GLNE_VIBVU
Sequence: MSLPSPLIPVAELAMQNAQQSGYLEHWPQALITQFQFISGLSKFVVETVQRDAQLAESLPEMLAQESRQEAYRTRLAEQLQACHDEVAGHRVLRQFRNREMVYIAWKDFTQAWSLEESLSHLSELAEAMIFETYQWQYQLCCKEWGTPTNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRLIKALDQQTFDGFCYRVDMRLRPFGESGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGREMYPEYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNIKLGAGGIREIEFIAQVFQLIRGGREPALRQRGLLVTLEAIKQLQLLEEAQVCHLVEAYKYLRRLENLLQAMADKQTQTLPDNELEQLALAVAMGYSQWQALQNDVQQHMAKVHAVFVTLIGDEEDEVSPVERHFNELWDMAHNPEVIEQILQNDLACQNAATMSEQIIQFKADLAKKTLGPRGREVLNRLMPKLFSAIFADADAQFGLPRVLHLLHNIATRTTYLELLDEHPAALTQLVRLCTASPMISEQLARYPILLDELIDPQQLYNPIALDAYRTELRDFLARIPEDDVEQQMDALRQFKQICSLRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVHQAWQQVAEKYGEPTHLKDREGKGFAVVGYGKVGGWELGYNSDLDVVFLHDCPVNVYTDGKKEIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVCPVDAFEEYQHNDAWTWEHQALVRARMIYGDEHLASEFHRVRHQVLAKPREQAKLQKEVADMRAKMRDHLGGKKSDRFMLKQDQGGITDIEFLAQYLVLNYSAEKPKLTRWCDNVRIFETLIAQGVMEEAQAMLLTQAYTTMRDEIHRRNLLNLDADVALDKFVALRQGVSKAWQEWLESSTI
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: SYD_ECOHS
Sequence: MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRARDEKNINRDMATGEIEVLASSLTIINRADVLPLDSNHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDVADLLKSVEFAVFAGPANDPKGRVAALRVPGGASLTRKQIDEYGNFVKIYGAKGLAYIKVNERAKGLEGINSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKKIVADAMGALRLKVGKDLGLTDESKWAPLWVIDFPMFEDDGEGGLTAMHHPFTSPKDMTAAELKAAPENAVANAYDMVINGYEVGGGSVRIHNGDMQQTVFGILGINEEEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANPTALAELSIQVVKKAENN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPH_ASPFU
Sequence: MASVQAYAQWVTVHLINSMSSETLSIQNASLSWGKWYKDGDKDAEITSEDVQQKTAPPGGSVNVNSCGRSDASSGTTGGFDLYDGNTKIGRVHWDCPWGSKTNDFDVGERNKNYWVEIGTWNKYGGAIGTVDVEVGRKR
What are the official names of this protein?
Asp-hemolysin, Asp-HS.
What is the protein family that this protein belongs to?
Belongs to the aegerolysin family.
Protein: TRPF_METKA
Sequence: MVRVKICGITRPEDAATADEAGTDAVGCVVEVPVSTPRKVSAEHANEVFSVVSPFVSRVAVLMDNLEPIDRLEEATAVQLHGTEDPETCEELSELGLDVIKTFWVDQRGSVWLGEELIGDEVLAEYCEIVDAVLLDTKSAEGGGSGERHDWDASARLVRRLDVPVILAGGLNPENVREAVEKVRPYAVDTSSGVEKEPGIKDPEAIAEFVRATKSV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MUG_SALTY
Sequence: MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLLDFRCGVTKLVDRPTVQATEVKLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRGIAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELDQALIMRGL
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP19_CHICK
Sequence: MSAESPEPASAEEQKEMEDKVISPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPTAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).
What are the official names of this protein?
cAMP-regulated phosphoprotein 19, ARPP-19.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_STRP1
Sequence: MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HPPA_RHILO
Sequence: MTILYAVIACGLLSVLYAIWATRSVLASDQGNARMQEISAAIREGAQAYLARQYTTIALVGVVVLLLAWWLLSITAAIGFLIGAVLSGAAGFIGMHVSVRANVRTAQAASNSLAAGLDIAFKSGAITGMLVAGLALLGVSIYYLILTGPMGLQPNDRIVIDSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVVATMVLGAIFFGGTAVLGAAMLYPLAICGACILTSIVGTFFVKLGANGSIMGALYKGLIVTGLLSIVGLAVATSVCFGWGEIGTVAGMVITGKNLFICGLIGLAVTGLIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGIISTYQLAGLYGTAIAVTTMLGLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGALVLFAAYSNDLKFFAANGDKYPYFQGMGEISFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAAGAIVEEVRKQFREDPGIMAGTSKPNYARAVDLLTKAAIREMIIPSLLPVLAPLVVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTSGGGAWDNAKKSFEDGFTDKDGVKHLKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAHG
What is the function of this protein?
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane.  Generates a proton motive force.
What are the official names of this protein?
K(+)-insensitive pyrophosphate-energized proton pump, Membrane-bound proton-translocating pyrophosphatase, Pyrophosphate-energized inorganic pyrophosphatase, H(+)-PPase.
What is the protein family that this protein belongs to?
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IMB4_YEAST
Sequence: MDQQFLSQLEQTLHAITSGVGLKEATKTLQTQFYTQPTTLPALIHILQNGSDDSLKQLAGVEARKLVSKHWNAIDESTRASIKTSLLQTAFSEPKENVRHSNARVIASIGTEELDGNKWPDLVPNLIQTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALFSQTINDPSSLEIRSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLNDFLLLDSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLSYRKSKVSQSKLGPEITVAALKVACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSELPPSQVASVIVEHIPAMLQSANVFERRAILLAISVAVTGSPDYILSQFDKIIPATINGLKDTEPIVKLAALKCIHQLTTDLQDEVAKFHEEYLPLIIDIIDSAKNIVIYNYATVALDGLLEFIAYDAIAKYLDPLMNKLFYMLESNESSKLRCAVVSAIGSAAFAAGSAFIPYFKTSVHYLEKFIQNCSQIEGMSEDDIELRANTFENISTMARAVRSDAFAEFAEPLVNSAYEAIKTDSARLRESGYAFIANLAKVYGENFAPFLKTILPEIFKTLELDEYQFNFDGDAEDLAAFADSANEEELQNKFTVNTGISYEKEVASAALSELALGTKEHFLPYVEQSLKVLNEQVDESYGLRETALNTIWNVVKSVLLASKVEPESYPKGIPASSYVNADVLAVIQAARETSMGNLSDEFETSMVITVMEDFANMIKQFGAIIIMDNGDSSMLEALCMQVLSVLKGTHTCQTIDIEEDVPRDEELDASETEATLQDVALEVLVSLSQALAGDFAKVFDNFRPVVFGLFQSKSKNKRSSAVGAASELALGMKEQNPFVHEMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQKALAAEDDEATREIIDRAYANASGCVARMALKNSALVPLEQTVPALLAHLPLNTGFEEYNPIFELIMKLYQENSPVITNETPRIIEIFSAVFTKENDRIKLEKESTLGREENMERLKQFQTEEMKHKVIELLKYLNTTYNGIVAQNPVLAAVIA
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Its predominant cargo substrate seems to be ribosomal proteins (PubMed:9321403).  Required for import of the ribosomal assembly factor NMD3 (PubMed:12612077).  May be involved in nuclear transport of YAP1 (PubMed:11274141).  Mediates the nuclear import of histones H3 and H4 (PubMed:11694505).  Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins.  The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015).  At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo (PubMed:9321403).  The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).
What are the official names of this protein?
Importin subunit beta-4, Importin-123, Karyopherin subunit beta-4, Karyopherin-123, Ran-binding protein YRB4.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nuclear pore complex.
Protein: KSTR2_MYCTO
Sequence: MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV
What is the function of this protein?
Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
What are the official names of this protein?
HTH-type transcriptional repressor KstR2.
Protein: IPTXI_PANIM
Sequence: MHTPKHAIQRISKEEMEFFEGRCERMGEADETMWGTKWCGSGNEATDISELGYWSNLDSCCRTHDHCDNIPSGQTKYGLTNEGKYTMMNCKCETAFEQCLRNVTGGMEGPAAGFVRKTYFDLYGNGCYNVQCPSQRRLARSEECPDGVATYTGEAGYGAWAINKLNG
What is the function of this protein?
Phospholipase toxin, which may catalyze the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  Inhibits both skeletal (RYR1) and cardiac (RYR2) ryanodine receptors (calcium release channels).  Probably blocks ryanodine receptors by generating a lipid product.
What are the official names of this protein?
Phospholipase A2 imperatoxin-1, Imperatoxin I, IpTx1, IpTxi, Imperatoxin inhibitor.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYL_METMP
Sequence: MDQKEVIGETGHKSVDLIKIMDKWQKKWTEAKIFEAEHDSRDKFFITAAFPYLNGVLHAGHLRTFTIPETIARYQRMKNKNVLWTFGFHVTGTPILGLANQIKERKEDIIWAYNNLHNIPMDELLKLNTPEAIVECFSKKATEAFKRMGFSLDWRRNFKTDDKVFSKFIEWQFYKLKEMGHITKGSHPVRYCPKCENPVEDHDLLHGEESTTVEYSLIKFTSKFDGKEIIMPMATLRPETVFGVTNAWVNPNEIYVMAEVHDEIQKLDSEDVDLKYNGIWIIGKECADKLKEQDRKIEILKEIKGSELLGLKIKNPVTKKEVPLLPADFVEMGIGTGCVMSVPAHAPYDYVALRDLGKVEEVGLIPLIEIEGYDKYPAKEIVEKLGIKDQNDEELLEQATSKIYKDEFHKGKLNENCGEYTGISVKDIKEKLTKDYINSNIAEIMYEFSEQKVVCRCGEKCIIKTVKGQWFINYSDENWKKLAHECIDNMNFAPEGIRQEFHNKVDWMKDKACARKRGLGTILPFDENWIIESLSDSTIYMAYYTIARFINEGLTPEQLIPELFDYVYLGNGNAEEIAKNSKIQAETIEEMRKEFLYYYPLDWRCSAKDLIPNHLTFMIFNHVALFGREHWPRGIEINGYVTIEGKKLSKSKGPVLPVSEVAENFGADVARFYITTCAELPQDADVKFKEMEKARDNLIKLYDLAVSVMEEESAEKELSLIDKWLLHKTYSSINSAETAYEEFQLRKIGLMFYELINDLRWYKRRGGENNSVLKEVVEIWTKLLSPVTPHLCEEIWEKLGYAGFISQEMYPVSKPELINEDLELGEEFIKSAMEDIRNIKGVAKINPEKMYLYTADDWKYDLLEFMNENAEKNVKALIPMVMKEDKFKRHGKEVMKLINEIMKIGVKKAIAEVEILENAKTFIESEFDCKVIVNGEDVKGKKKFAIPYKPAIYME
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT330_ASPTN
Sequence: MTQRLLRLSLAHYRKDSCTEESCHYFGTALHAKQAATLHAKHGTLQYYQVYSTQAARDALDAFRRSLGADWTIDQHDLTVELYIRDLQTLRNIAADPEFASFYHLEEPYLSRRHVVASLGWVEAYVEEGKVVNVTDEGSEYRPGFGEFVGSGGELEKALA
What is the function of this protein?
Putative oxygenase; part of the gene cluster that mediates the biosynthesis of isoflavipucine (PubMed:21236704).  The PKS part of the PKS-NRPS ATEG_00325 probably assembles a triketide from an acetyl starter and two malonyl-CoA extender units (PubMed:21236704).  The poly-beta-keto intermediate would then be fused to the leucine unit by the NRPS part (PubMed:21236704).  The resulting amide would be liberated from the PKS-NRPS through reductive release of the linear PKS-NRPS product from the enzyme complex (PubMed:21236704).  Further steps in isoflapucine synthesis include a cyclization step, an oxidation step, a hydrolysis step involving a trans-amidation, and an additional oxidation step, leading to flavipucine (PubMed:21236704).  Formation of isoflavipucine from flavipucine requires an unusual rearrangement (PubMed:21236704).  Alternative rearrangement reactions could build up rubrobramide, representing a branching of flavipucine biosynthesis (PubMed:21236704).  The enzymes involved in the post-PKS-NRPS steps have not been identified yet, but the putative oxygenases ATEG_003329 and ATEG_00330 encoded by the cluster could play a role (PubMed:21236704).
What are the official names of this protein?
Putative oxygenase ATEG_00330, Isoflavipucine biosynthesis cluster protein ATEG_00330.
What is the protein family that this protein belongs to?
Belongs to the tpcK family.