PharMolix/UniProtQA huggingface dataset:
Protein: TGT_HAEIE
Sequence: MKYELDKTSGNARRGRLVFERPQGTFSVETPAFMPVGTYGTVKGMTPEEVRATGAEILLGNTFHLWLRPGQEIMRKHGDLHDFMQWHRPILTDSGGFQVFSLGKLRKITEEGVKFQNPINGERIFLSPEKSMEIQYDLGSDIVMIFDECTPYPATFDYAKKSMEMSLRWAKRSRDRFDELGNKNALFGIIQGGVFEELRKVSLEGLVNIGFDGYAVGGLAVGEPKEDMHRILEYICPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGIVKIRNAKYRDDTSPLDPECDCYTCKNYTKAYLYHLDKCGEILGARLNTIHNLRYYQRLMAEIRQAIEDDRFDDFVVEFYARMGKPVPPLQLADKS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ASSY_ALKMQ
Sequence: METKNKKKVVLAYSGGLDTSVILKWLEETYGYEVIAACVNVGQTEDFAAIKKKALATGASKAYIVDVTEEFITDYIFPTLKAGAVYEDDYLLGTSFARPLISKKLVEIAEKEGAVAIAHGATGKGNDQVRFEATIKALNPNLKIIAPWRTWDLKSREDCIDYAVQHGIPIPVTKKDIYSRDENIWHISHEGGNLENPWNEHDDTIYKLSVSPEKSPDTPTYVELEFYKGIPVAVDGVKYEPIDMLTTLNKLGGAHGVGIIDIVENRLVGMKSRGVYETPGGTLLFAAHKALEKLTLDRDTTSFKKGISVKYAQLVYDGLWHTPLKDALDQFVNSTQEFVTGQVKLKLYKGNCTAVASASPFSLYNEDFVTFGEDHVYNQQDAEGFINLFALPLTIRALMLEEKLQGEAKEKKII
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASI2A_MACAT
Sequence: MAPLLKLNILLLIVLICFTFHANATHRCVRHGEYCNERIRLDCCFGDCVKNKCSDDF
What is the function of this protein?
May act as a neurotoxin.
What are the official names of this protein?
U-Asilidin(1)-Mar2a.
What is the protein family that this protein belongs to?
Belongs to the asilidin-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPIA_GLOC7
Sequence: MTVTNDPVVLMKQEVGKAAAQRVHSDTIIGLGTGSTTAYAIQYIGERIQTGELKNVVGVPTSFGAEVLARKYGVPLTTLDVIDKMDLAIDGADEVDPQKNLIKGGGAAHTREKIVDSLADVFIVVVDSGKLVDKLGSTFLLPVEVIPMAVTPVIKALEKLGGKTDLRMGVKKAGPVVTDQGNLVIDVKFDNIEDPANLEKTINNIPGVLENGLFVGVADLILVGEIIDGKPRVREIS
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: LUTB_BACC3
Sequence: MSMKISEKKFNDRVGDGIQDSFMRGAVSSAQTRLYTNRLKAADELGNWEEWRELGEEIRQHTLENLDYYLMQLSENVSKRGGHVYFAKTKEEAAKYIQDVAKKKQAKKVVKSKSMVTEEISMNHALEEIGCEVLESDLGEYILQVDNDPPSHIIAPALHKNRTQIRDVFKEKLGYENSDDPYEMTKFVRKQLREKFMDAEIGVTGCNFAVANTGSLCLVTNEGNADLVMSIPKTQIAVMGMERMVPTMEELDVLVGLLCRSAVGQKLTSYVTVAGPIQEEEVDGPEEFHLVVVDNGRSQILGSEFRQVLQCIRCAACVNVCPVYRHVGGHSYGSIYSGPIGAVLTPLLGGYDDYKELPYASSLCGACTEACPVKIPLHDLLLKHRQVIVEQEGRAPLAEKLAMKMFSMGASSAALYKMGSKMAPAAMSPFTSGNRVSKGVGPLKNWTDIREFPAPSKERFRDWYKDHKKGGDK
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.  Has probably a role as an electron transporter during oxidation of L-lactate.
What are the official names of this protein?
Lactate utilization protein B.
What is the protein family that this protein belongs to?
Belongs to the LutB/YkgF family.
Protein: Y2901_MYCTO
Sequence: MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVEMVPRNTDGEVYFELRLADAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE
What are the official names of this protein?
Uncharacterized protein MT2969.
Protein: TRXB_MYCSM
Sequence: MSTSQTVHDVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQFGGALMTTTEVENYPGFREGITGPELMDQMREQALRFRADLRMEDVDAVQLEGPVKTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTCATCDGFFFRDQDIVVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRASKIMLERARANEKITFLTNTEITQIEGDPKVTGVRLRDTVTGEESKLDVTGVFVAIGHDPRSELVRGQVELDDEGYVKVQGRTTYTSLDGVFAAGDLVDHTYRQAITAAGSGCAASIDAERWLAEQD
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_CLOBL
Sequence: MSEIKVGENESLENALRRFKKKCARAGVLSEVRKREHYEKPSVKKKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: TYSY_BACCN
Sequence: MKHAEYEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKNWVESDEYKGPDMTNFGLRSQEDEAFKTQYDEQMEIFKKNVLEDDEFARKYGYLGDVYGKQWRAWKTAAGETIDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLAVGEFVHTIGDAHIYTNHFEQVKKQLAREPRPFPTLKLNSDVKSVFDFEMGDLTIEGYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_STRR6
Sequence: MKLLEERILKDGHILDDNILKVDSFLTHQVDFSLMREIGKVFAEKFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQDGRDLLEKAGYPVLSLARLDRFENGQVVFKEADL
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPA_SALTI
Sequence: MSQTIDLTLDGLSCGHCVKRVKESLEQRPDVELADVTVTEAHVTGTASADALIETIKQAGYGATLSHPKAKPLTESSIPSEALAAVPHELPVATADEESQQLLLSGMSCASCVTRVQHALQSVPGVTQARVNLAERTALVMGSASAADLVQAVEKAGYGAEAIEDDIKRRERQQETAIATMKRFRWQAIVALAVGIPVMVWGMIGDNMMVTGDNRSLWLAIGLITLAVMVFAGGHFYRNAWKSLLNGTATMDTLVALGTGVAWLYSMSVNLWPQWFPMEARHLYYEASAMIIGLINLGHMLEARARQRSSKALEKLLDLTPPTARVVTEDGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQGEAWLDEAMLTGEPIPQQKGEGDSVHAGTVVQDGSILFRASAVGSHTTLSRIIRMVRQAQSSKPEIGQLADKISAVFVPVVVAIALFSAAIWYFFGPAPQIVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVVAVKTFNGVDEAQALRLAAALEQGSSHPLAHAILEKAGDDKLPQVNGFRTLRGLGVSGEAEGHQLLLGNQALLNEQHVATDDMTAEITAQASQGSTPVLLAIDGKAAALLAVRDPLRSDSIAALERLHNAGYRLVMLTGDNPTTANAIAKEAGIDEVIAGVLPDGKADAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQNLLGAFIYNSIGIPVAAGILWPFTGTLLNPVVAGAAMALSSITVVSNANRLLRFKPKA
What is the function of this protein?
Probably also encodes a cytoplasmic copper chaperone CopA(Z) that is produced by programmed ribosomal frameshifting (Probable).
What are the official names of this protein?
Copper-exporting P-type ATPase, Copper-exporting P-type ATPase A, Cu(+)-exporting ATPase, Soluble copper chaperone CopA(Z).
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
[Copper-exporting P-type ATPase]: Cell inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform Soluble copper chaperone CopA(Z)]: Cytoplasm.
Protein: HEM1_PROM1
Sequence: MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVKDPQLGIEAIKSFLLEFSGLEDEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQVKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQAHGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQIDCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKSVSGIESHDVDDLQEVVSRNQEARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSSLESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTKLRAPQSRNDRRDSLDVIEKLFNLDVSSSLNKPKNN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: DPO1_STRPN
Sequence: MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNVAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDHMGIRHYDLAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVAEFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVSESLDFTIVDQISQDMLSEESIFHFELFGENYHTDNLVGFVWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, POL I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: NUOB_SHIDS
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIAKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPA1_NITMU
Sequence: MHLNPSEISELIKSRIEGLEATAEVRTQGTVVSVTDGIVRIHGLSDVMQGEMLEFPGNTFGLALNLERDSVGAVVLGEYEHITEGDTVKCTGRILEVPVGEELIGRVVNALGQPIDGKGPITTKHSEPIEKIAPGVVWRQSVNQPVQTGLKAIDAMVPIGRGQRELIIGDRQTGKTAVAVDAIINQKGENMICIYVAIGQKASSISNVVRKLEEHGAMEYTIVVAATASESAAMQFIAPYSGCTMGEYFRDTGRDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVSAAYVEKETNGAVKGKTGSLTALPVIETQAGDVTAFVPTNVISITDGQIFLESDLFNAGIRPAINAGISVSRVGGAAQTKVIKKLGGGVRLALAQYRELAAFAQFASDLDEATRKQLERGKMVTELMKQPQYSTLSVSEMALTLFAVNKGYLDDVEVSRALAFESALRGFIRSKYGAILDKIETTKDLDAETEKELDAAIQDFKKNGTY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y197_LEGPH
Sequence: MTMMITTGNSFEGKVIKQYLGIVRGIVVRSPTISQGLMGGLKSIVGGKIGAYSEMCEHAREEAFQLMIEHAQALNANGIIAMRYDTGEIGQAGTEVLCYGTAVII
What are the official names of this protein?
UPF0145 protein lpg0197.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: SABP2_TOBAC
Sequence: MKEGKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASGTDLRKIEELRTLYDYTLPLMELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFLAAFMPDSVHNSSFVLEQYNERTPAENWLDTQFLPYGSPEEPLTSMFFGPKFLAHKLYQLCSPEDLALASSLVRPSSLFMEDLSKAKYFTDERFGSVKRVYIVCTEDKGIPEEFQRWQIDNIGVTEAIEIKGADHMAMLCEPQKLCASLLEIAHKYN
What is the function of this protein?
Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue.  MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect.  Also able to catalyze the conversion of acibenzolar-S-methyl into acibenzolar to induce systemic acquired resistance.
What are the official names of this protein?
Salicylic acid-binding protein 2, NtSABP2, Methyl salicylate esterase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Methylesterase family.
Protein: YXCA_BACSU
Sequence: MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFLNASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG
What are the official names of this protein?
Uncharacterized protein YxcA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMD_ACTP7
Sequence: MWIGIISLFPEMFKAITDFGVTGRAVKQDLLQIQCWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHAAKQAAKAEDGVEAKVIYLSPQGRKLDQQGVKTLASNQKLILICGRYEGVDERLIQTEVDEEWSIGDYVLTGGELPAMTLIDAVARFVPGVLGKQASADEDSFATGLLDCPHYTRPEMLDGIPVPEVLMSGHHENIRKWRLEQSLERTWLRRPELLDSLALTDEQRVLLAKIKKQHKIS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_CLOTE
Sequence: MRKIAVLTSGGDAPGMNAAIRAVVRTGLDKGITVLGIERGFDGLLNGEIFEMTRRSVADIIQRGGTILRTARSEEFKTEEGQKKATDILRVFGVEGLVVIGGDGSFQGAKSLSELGVKTIGIPGTIDNDLAYTDYTIGFDTAVNTVLDAINKLRDTSTSHGRASVVEVMGRNCGDIALYAGLAGGAESIIVPELRFDIDKLCKTILEGKKNGKMHNLIIVAEGAGKANDIAKTIEKVTGVGTRATVLGHIQRGGSPTANDRILASRMGNRAVELLLEEKSSRVVGINDNRIVDMDIHEALSIEGKFDEKLYEIAKALSY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCB5R_DEBHA
Sequence: MSQPEPNPFIIFATVAAIISSAVAYYFFQLSRKNAPVLKPNDFQKFPLIEKTRVSHNTCVYRFGLPRSTDRLGLPIGQHIAIGATINDKEVVRSYTPISTDDELGYFDLLIKAYENGNISRHVESKKIGETIDIRGPKGFFTYTPGMVESFGMIAGGTGITPMYQILTAILRNPEDKTKVSLVYANVTEDDILLKEELNKMAREHPDRFKIYYVLNTPPENWTGGVGFVTPEIMDKHLPKASEATNLLLCGPPPMISAMKKAAVGLGYQKAKPVSKLGDQIFVF
What is the function of this protein?
NADH-dependent reductase for DPH3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.  By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: CBTA_ECOLI
Sequence: MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
What is the function of this protein?
Toxic component of a type IV toxin-antitoxin (TA) system (PubMed:14594833, PubMed:21166897, PubMed:22515815, PubMed:28931012, PubMed:28257056).  Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB (PubMed:28931012).  Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization (PubMed:21166897, PubMed:28931012).  Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division (PubMed:21166897, PubMed:28931012).  Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; these effects are overcome by concomitant expression of antitoxin CbeA (YeeU) (PubMed:14594833).  In other experiments cells swell, by 6 hours are lemon-shaped and by 24 hours those that have not lysed are spherical with diminished polar regions (PubMed:21166897, PubMed:28931012).  Toxic effects are neutralized by cognate antitoxin CbeA, although there is no direct interaction between the 2 proteins (PubMed:14594833, PubMed:22515815).  Toxic effects are also neutralized by overexpression of noncogate antitoxins YafW and YpjF (PubMed:28257056).
What are the official names of this protein?
Cytoskeleton-binding toxin CbtA, Toxin CbtA, Toxin YeeV.
What is the protein family that this protein belongs to?
Belongs to the CbtA/YkfI/YpjF toxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXW_MYCTU
Sequence: MTSRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS
What are the official names of this protein?
ESAT-6-like protein EsxW.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. CFP-10 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS) (Probable). May bind to lipid membranes after dissociation of the complex (Probable).
Protein: RDGC_XANC8
Sequence: MFFRNLTLFRFPTTLDFSEIETLLPQVQLKPVGPLEMSSRGFISPFGRDEQDVLSHRLEDFLWLTVGGEDKILPGAVVNDLLERKVAEIEEKEGRRPGGKARKRLKDDLIHELLPRAFVKSSRTDAILDLQHGYIAVNTSSRKSGENVMSEIRGALGSFPALPLNAEVAPRAILTGWIAGEPLPEGLSLGEECEMKDPIEGGAVVKCQHQELRGDEIDKHLEAGKQVTKLALVMDDNLSFVLGDDLVIRKLKFLDGALDQLEHSEGDGARAELDARFALMSAEVRRLFLLLEDALKLSKAEA
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL22_PSELT
Sequence: MVSENEKTRRPKRSIQHRQNKDENNIEIKAVAKFLRASPRKVRSVANTIRGKSVSEAFQVLEMSPKKAARLIEKVLRSAVANAENNANLSSDSLYISRCFVDDGPRYKRIWPRGRGRADIIQRRMCHVTVAVKSIEAKS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MOAA_MYCS2
Sequence: MTVTALGLPTVARSTGDGSAGASPAPADGPLVDTYGRAATDLRVSLTDRCNLRCTYCMPAEGLNWLPGDALLSPTELARLLRIAVARLGITSVRFTGGEPLVVRHLEEVVAAAAALEPRPEITLTTNGLGLARRAEGLKKAGLNRINVSLDSVDAAHFARITRRDRLPDVLAGLAAAKAAGLEPVKVNAVLDPVSGLDDAVELLRYCLQHGYQLRIIEQMPLDASHSWQRDNVIDADRILQTLQQHFELTPDSRPRGSAPAELWQVAEGPTHAAGTVGVIASVSHAFCSACDRTRLTADGQIRSCLFSREETDLRHLLRGGADDAEIEAAWRAAMWSKPAGHGINDPDFVQPVRPMSAIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: FBL50_ARATH
Sequence: MEQLNPASMDCLPDELLVEILSSLTTKQAVSTSLLSKRWKTLYSLVHNLDIDDYILFHREDGYHRYRPDIQKSFEDFVERTLAFRGHIKTFSLKSRELYAFGLGVDVVNRWICNALERGVSELHLCINSQFELPYKFFTSTTLVMLSLGRGLVCSKIPPETSLPVLKILFLYSIWFKDLTRHVVDLYYSDLPRRKAPHCHLDSLAKVTLDLHYLRYGYQKVQNYANVKNIISEIRNVKTLHLTSSAVEVISVCRKDGLPVFNNLVELMFSSRKRHRKVLPLLLERSPNLETLILSDLYRYTYGRRHRFVGIQIPANNKIKMLSFMQYQGSATELKHISHLLLKMECLEVVKVYLATEMNDLKKMQLTEDEVKLPAASSKVKIQVMGS
What are the official names of this protein?
Putative F-box/LRR-repeat protein At3g44080.
Protein: RS10_AGRFC
Sequence: MTGQNIRIRLKAFDHRILDASTREIVSTAKRTGASVRGPVPLPTRIEKFTVNRSPHVDKKSREQFEMRTHKRLLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: HTPG_SHEPA
Sequence: MSQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYEALTNDNLYEGDGELRVRISADKEKGTVTIEDNGIGMTRDGVIEHLGTIAKSGTADFFKKLSGDESKDSQLIGQFGVGFYSSFIVADRVTVRTRAAGHSADEAVLWESAGEGDFTVETISKQTRGTEITLHLRDDEKEFADDYRLRSIITKYSDHISVPVEMFEAGTPAVEATEDTEAVAATEGSWKPMNKATALWTRNKSDVSDEEYQEFYKHISHDFTDPLLWSHNRVEGKQEYTSLLYIPAKAPWDMWNRDRKHGLKLFVQRVFVMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNKVTTALRTAVTKRVLGMLEKLAKNDAEKYQSFWTEFGQVLKEGPAEDFANKERIAGLLRFASTHTGEATPNVSLADYIERMQEGQSKIYYIVADSHEAAANSPHLELLRKKGIEVLLMSERIDEWLINHLTEFDGKKLHSVTRGDLELGELEDDDEKEAQEKLQTESEGLVKRVKDSLGDKVSEVKVTTRLTDTPACVVAGEGEMSTQMIKLMQAAGQDVPEPKPTFELNPEHPLVARLNDEQDEQQFAQWSELLLQQALLSEKGSLADPSAFIKLMNQMLLASVK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCC_ECOL5
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.