PharMolix/UniProtQA huggingface dataset:
Protein: GLO2_PASMU
Sequence: MLVPIPALNDNYIWLYGRANLPIIVIDIPEFTPLLDYVQQHQLNVEALLLTHHHDDHTAGVSLFKQHFPNVKVFGPAETQAKGATEIVNMGILQTEHYHIHVLQTAGHTEQHVSYLVDGHLFCGDSLFSAGCGRVFTGNYQHMFDGLQRLKSLPDDTIVCPAHEYTLANLAFAKYILPENVAIQQHEQWVQKQRVTHQPSLPTTMGREKQINPFLIAQDMETFVAWRKAKDVF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: RS3_BACTN
Sequence: MGQKVNPISNRLGIIRGWDSNWYGGNDYGDSLLEDSKIRKYLNARLAKASVSRIVIERTLKLVTITVCTARPGIIIGKGGQEVDKLKEELKKVTDKDIQINIFEVKRPELDAVIVANNIARQVEGKIAYRRAIKMAIANTMRMGAEGIKIQISGRLNGAEMARSEMYKEGRTPLHTFRADIDYCHAEALTKVGLLGIKVWICRGEVFGKKELAPNFTQSKESGRGNNGGNNGGKNFKRKKNNR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: INTU_RAT
Sequence: MADPARRDPRGRAPELPGDLSSQEEEEEESDSDAGASSLGSCSSASSDTDLEPEWLDSVQRNGELFYLELSEDEEESLLPETQTVNHVNHVRFSEKEVIIEEDDSRERKKYEPKLRRFTKILKSKSLLPKRHHKKKSSNTGPVSILKHQSTQRTGVTVQQRYKDVTVYINPKKLTAIKAREQAKLLEVLVGVIHQTKWSWKRSGKQADGERLVVHGLVPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKKETAQPKKKKAQSSTNDLVKLLCGSEADATQHSTLSIPHITMYLTLQLQSEVAREEQEMLYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHVNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMTEDVAQTLKFMYGSLDSAFCQVENTPRLDHFFSLFFERALRPGKLHLSASPSAQQYDAASAVLLDNLPGVRWLLLPQELKVELDTALSDLEAADFQELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVVEIAAYCRQYCLLPLAAQQRIGQLIIWREVFPQHHLQPATDSDPEAFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASKATGNPGPDCIYVDQARATLHQLEGVESRIEEQLAATPGPCLSCADWFLAAPREKADSLTTSPILGRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPGEGEENVGLSPHTTPDTVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYNMMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHRCCLTIRAVFQQTLKVEKKKALSDGDHLESANSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFRLFFGLTL
What is the function of this protein?
Plays a key role in ciliogenesis and embryonic development.  Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules.  Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension.  Has an indirect effect on hedgehog signaling (By similarity).  Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
What are the official names of this protein?
Protein inturned, Inturned planar cell polarity effector homolog, PDZ domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the inturned family.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Cytoplasm, cytoskeleton, cilium basal body. Note=Enriched at the apical surface in ciliated cells.
Protein: YJIN_ECOLI
Sequence: MNKLIELRRAKRLALSLLLIAAATFVVTLFLPPNFWVSGVKAIAEAAMVGALADWFAVVALFRRVPIPIISRHTAIIPRNKDRIGENLGQFVQEKFLDTQSLVALIRRHEPALLIGNWFSQPENARRVGQHLLQIMSGFLELTDDARIQRLLKRAVHRAIDKVDLSGTSALMLESMTKNDRHQVLLDTLIAQLIALLQRDKSRKFIAQQIVRWLESEHPLKAKILPTEWLGEHSAELVSDAVNSLLDDISRDRAHQIRHAFDRATFALIDKLKNDPEMAARADAVKSYLKEDEAFNRYLSELWGDLREWLKVDINSEDSRVKERIARAGQWFGETLIADDALRASLNGHLEQAAHRVAPEFSAFLTRHISDTVKSWDARDMSRQIELNIGKDLQFIRVNGTLVGGCIGLILYLLSQLPALFPLGNF
What are the official names of this protein?
Uncharacterized protein YjiN.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSB1_ZYGRC
Sequence: MAEGVFQGAIGIDLGTTYSCVATYESSVEIIANEQGNRVTPSFVAFTPEERLIGDAAKNQAALNPENTVFDAKRLIGRRFDDESVQKDRKTWPFKLIDVEGNPVVEVQYLGETKTFSPQEISSMVLTKMKEIAEAKIGQKVEKAVITVPAYFNDAQRQATKDAGSISGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLHIAGGVYTVKSTSGNTHLGGQDFDTNMLEHFKNEFKKKTGNDISGDARALRRLRTACERAKRTLSSVTQTTIEVDSLYNGDDFETSITRARFEDLNSSLFKSTLEPVEQVLKDAKVPKTEIDEVVLVGGSTRIPKVQKMLSDFFEGKQLEKSINPDEAVAYGAAVQGAILTGQSTSEDTKDLLLLDVAPLSLGVGMQGDIFGIVVPRNTTVPTIKRRTFTTVADHQSTVQFPVYQGERVNCKENTLLGEFDLKNIPPMQAGEPVLEAIFEVDANGILKVTAVEKSTGKSANITISNAVGRLSSDEIEKMVNQAEEFKAADEAFAKKHEARQRLESYVASIEQQVTDPVLSSKLKRGSKTKIESALSDALASLEIQDASTDDLRKAEVGLKRVVTKAMSSR
What is the function of this protein?
Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol.  Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized.  The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD.  The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state).  During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain.  Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state.  Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release.
What are the official names of this protein?
Ribosome-associated molecular chaperone SSB1, Heat shock protein SSB1, Hsp70 chaperone Ssb.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with translating ribosomes.
Protein: AKH_STRNA
Sequence: QVNFTPSW
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic hormone, AKH.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEGPL_PSE14
Sequence: MSIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAIANQQMPDLEGLPPMLREFLERSMPPGSRPPGAGKGDRQRETQSLGSGFIISPDGYILTNNHVIDGADEILVRLSDRSELKAKLIGTDSRTDVAVLKIDGKDLPTAKLGNSNTLKVGEWVLAIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINSQIFTRSGGFMGLSFAIPIDVAMDVANQLKASGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQVLEDGPAAKGGLQVGDVILSANGQPIIMSADLPHLIGNLKDGSKAELEVIRDGKRQKLTVTVGALPDEGQEMGDVAGTGAERSSNRLGVSVIELTAEQKKSLDLKGGVAIKEVTGGPASLIGLQPGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLSE
What is the function of this protein?
Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
What are the official names of this protein?
Probable periplasmic serine endoprotease DegP-like, Protease Do.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HXD8_CHICK
Sequence: MSSYFVNPLYSKYKAAAAAAAAVAAGEPLPAPYYDCHFAPERQQIFTTQQEAELVQYPDCKSSSANIGEEPDHLNQSSSPAQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPASKQEGKEGEAKKETHDLEDDRAESHTN
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D8, Homeobox protein Hox-M, Chox-M.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTA10_ARATH
Sequence: MQICQTKLNFTFPNPTNPNFCKPKALQWSPPRRISLLPCRGFSSDEFPVDETFLEKFGPKDKDTEDEARRRNWIERGWAPWEEILTPEADFARKSLNEGEEVPLQSPEAIEAFKMLRPSYRKKKIKEMGITEDEWYAKQFEIRGDKPPPLETSWAGPMVLRQIPPRDWPPRGWEVDRKELEFIREAHKLMAERVWLEDLDKDLRVGEDATVDKMCLERFKVFLKQYKEWVEDNKDRLEEESYKLDQDFYPGRRKRGKDYEDGMYELPFYYPGMVCEGTVTTLHLYQGAFVDIGGVHEGWVPIKGNDWFWIRHFIKVGMHVIVEITAKRDPYRFRFPLELRFVHPNIDHMIFNKFDFPPIFHRDGDTNPDEIRRDCGRPPEPRKDPGSKPEEEGLLSDHPYVDKLWQIHVAEQMILGDYEANPAKYEGKKLSELSDDEDFDEQKDIEYGEAYYKKTKLPKVILKTSVKELDLEAALTERQHHNKLMMEAKARGEGYKIDKLRRNIEMDEYDFLHWRRSLEEREALLRDISSRQALGLPLEEPGRYKPGSFFGKDQYDPTSALYQYDYWGEPKNSEISKQERMKDAHNKSIVGKGNVWYDMSYDDAIKQTIEKRKEGSTLASQEEETESEEEEEDDDDFDDFDYSILSDESSIGYSEQQPLVNGTQVLTD
What are the official names of this protein?
Protein PLASTID TRANSCRIPTIONALLY ACTIVE 10, pTAC10, Plastid-encoded RNA polymerase-associated protein 3, PEP-associated protein 3, Protein PIGMENT DEFECTIVE 312.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UCHL1_BOVIN
Sequence: MQLKPMEINPEMLNKVLTRLGVAGQWRFEDVLGLEEESLGSVPAPACALLLLFPLTAQRCFKLGREAASRFHHPDYPGRLFILLVSQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGTSSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
What is the function of this protein?
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.  This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).  Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).  The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor.
Protein: YTLI_BACSU
Sequence: MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLGVLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTASLIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFFYDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKMELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHFDRATKDLIARITKRFQQRSKELEGTSDKTITG
What is the function of this protein?
Positively regulates the expression of ytmI operon in response to the availability of sulfur sources.
What are the official names of this protein?
HTH-type transcriptional regulator YtlI.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RNFA_SHEB9
Sequence: MTEYLLLLISTVLVNNFVLVKFLGLCPFMGVSSKLESAIGMSMATTFVLTLASILSYLVNQYLLLPFDLSYLRTMSFILVIAVVVQFTEMVVQKTSAALHRALGIYLPLITTNCAVLGVALLNVNEKHDFIQSAIYGFGAALGFSLVLILFSAMRERLAAADVPLPFKGGAIAMITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KLDC4_PONAB
Sequence: MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVEAPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNIRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGSPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYTFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIIIYGGYSKQRVKKDVDRGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSAAMALNHQTLFFGGVCDEEEEESLAGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRGRKEESEGGSKLACGGAGTQGPVQVVKEVVAEDGTVVTIKQVLAAPGSAGQPRSEDEDSPEEAGSSAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGDEDEDEDSREESGAED
What are the official names of this protein?
Kelch domain-containing protein 4.
Protein: PLS11_PHYTB
Sequence: FLSLIPKIAGGIASLVKNL
What is the function of this protein?
Antimicrobial peptide with activity against Gram-negative bacterium E. coli ATCC 25922 (MIC=25 uM), Gram-positive bacterium S. epidermidis ATCC 12228 (MIC=6. 25 uM) and against fungus C. albicans ATCC 24433 (MIC=50 uM) (PubMed:29980138).  Has an anti-inflammatory effect, since it inhibits the production of the pro-inflammatory cytokine TNF-alpha (PubMed:30734396).  Has an activity of stimulation of insulin release, which may protect the species from being eaten by predators by causing fatal hypoglycemia (PubMed:30734396).  Is cytotoxic to cancer line cells (PubMed:30734396).  Shows moderate hemolysis on mouse erythrocytes (LC(50)=28 uM) (PubMed:30734396).
What are the official names of this protein?
Phylloseptin-1.1TR, PLS-1.1TR.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EFC4A_DANRE
Sequence: MSPRSTLRSPLPSRTARSSASSDTPSPGADRQDRMSKAKELFVLCDKEGKGFITKRDMQRLQQELPLSPEQLESVFESLDRDRNGYLTPLEFHTGLGELVGSGPEEKVRSAGEIVGEEREEPTEIRFTQILMELGADKLFKDQWELCGLWCELQRDKPELLGVLEEVLSYTVSHLQDALKEKDNLEHALRRREEDHDRVVRSMYEDMESQLKEERERRQALDSMRQGDKKEQLLHELRTREQELEFTLTKQRELESRINSLSSDQADARGENRRLQNVNQQLQDQLEQSREELQNSLSQLQQLQNTIKLQQRGKEREVLKVSRNMQKERESLVRQLELLRDMNKRLRDDKDAHQAQKMVSQKHSFTPPTYYPACRCVHNFSPWPRSIYPY
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 4A, Calcium release-activated channel regulator 2B.
What is the protein family that this protein belongs to?
Belongs to the EFCAB4 family.
Protein: B4GT3_RAT
Sequence: MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPGAPGAAGAPLAQVLPDCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPHGSH
What is the function of this protein?
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
What are the official names of this protein?
Beta-1,4-galactosyltransferase 3, Beta-1,4-GalTase 3, Beta4Gal-T3, b4Gal-T3, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, N-acetyllactosamine synthase, Nal synthase, Neolactotriaosylceramide beta-1,4-galactosyltransferase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Protein: PUR7_CELJU
Sequence: MEKREQLYAGKAKSIFNTDDPDHLVMLFRNDTSAFDGKRVEQLDRKGMVNNKFNAFIMGKLQAAGIPTHFVKLLSDTEALVKKMDMIPVECVVRNLAAGSLVRRLGVQEGQVLNPPTFELFLKNDALGDPMINESHVESFGWATREQLARMKELTFKINEVLKDLFAAGNMLLVDFKVEFGLHKGEVILGDEFSPDGCRLWDKDTREKLDKDRFRQNLGNVVESYELVGQRLGLTF
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: COAD_TRIEI
Sequence: MIAIYPGSFDPITLGHIDIIERGCNLFEKVIVAVLRNQSKTSLFTIEQRLNQICHSTKHLLNVEVASFDGLAVNYAKMQQAKVLIRGLRVLSDFEKELQMAHTNKTLSPEIETVFLATSNEYSFLSSSVVKEIAVFGGSVDHLVPQHIAIDIYKCYDKTQPKPILNQR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOE_HYLLA
Sequence: MKVLWAALLVTFLAGCQAKVEQAVEPEPEPELRQQAEWQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYRSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEVGGRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RLM1A_ARATH
Sequence: MASSSSSASRTWRYRVFTSFHGSDVRTSFLSHFRKQFNNNGITMFDDQRILRGETISPALTQAIRESRISIVLLSKNYASSGWCLDELLEILKCKDDMGQIVMTVFYGVDPSDVRKQTGEFGIAFNETCACRTEEERQKWSQALNYVGNIAGEHLLNWDNEAKMIEKIARDVSEKLNVTPCRDFDGMVGIEAHLRKIQSLLDLDNDEVKMVAISGPAGIGKSTIGRALHSLLSNRFHHTCFVDNLRGSHPIGLDEYGLKLRLQEQLLSKILNQDGSRICHLGAIKERLCDMKVFIILDDVNDVKQLEALANESNWFGPGSRIIVTTENKELLKQHGINNTYYVGFPSDEEAIKILCRYAFRQSSSRHGFKKLTRSVTELCGKLPLGLRVVGSSLHGKNEEEWEYVIRRLETIIDRDIEQVLRVGYESLHENEQSLFLHIAIFFNYEDGDLVKAMLAENDLDIEHELNILVNKSLIYISTDGRIRMHKLLQLVGRQANQREEPWKRRILIDAQEICHVLENDIGTGAVSGILFDTSGINEVSISNKALRRMCNLRFLSVYKTKHDGYNRMDIPEDMEFPPRLRLLHWDAYPSKCLPLKFRAENLVELDMKDSRLEYLWPGTQLLTKLKKLNLEGSYNLKELPDLSNATNLEMLDLSVCLALAELPSSIKNLHKLDVIYMDLCESLHMIPTNINLASLETMYMTGCPQLKTFPAFSTKIKRLYLVRTGVEEVPASITHCSRLLKIDLSGSRNLKSITHLPSSLQTLDLSSTDIEMIADSCIKDLQRLDHLRLCRCRKLKSLPELPASLRLLTAEDCESLERVTYPLNTPTGQLNFTNCLKLGEEAQRVIIQQSLVKHACFPGSVMPSEFNHRARGNSLKILVKSSASFAFKACVLISPRQLQCERNQRRVKIRCRVTDGRGRFVGSKVVSLEHPNHSTGIRTKHLCFFNGVLTEVSCDALCFVFKISAYNPLDNYEISECAVQILTNEPERRSCDGGSE
What is the function of this protein?
TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Leptosphaeria maculans (blackleg disease).
What are the official names of this protein?
Disease resistance protein RML1A, Protein RESISTANCE TO LEPTOSPHAERIA MACULANS 1A.
Protein: PSBH_PROM3
Sequence: MAQSTRLGNLIKSLPGYAPGKVVPGWGTTPVMAGIGFMLLIFLVTILQIYNQSLLLQSISFE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: VP54_BPAPS
Sequence: MVRFNCFITEQDGQGDHVTQIKRFNINRFRFRRYFRVFNHRFNGFSRFRFCLGDFTLFLGNNRCWLVIGFSVCFDNRRRLNDYFRLNDN
What are the official names of this protein?
Putative protein p54.
Protein: RECU_BACCN
Sequence: MTIRYPNGKRYNQALQPQKTKMKKHTYGNRGMSLEEELNETNQYYLSHNIACVHKKPTPLQIVKVDYPARSAAVVREAYFKQPSTTDYNGVYKGKYIDFEAKETKNKTNFPLQNFHLHQIEHMKQVIAHDGIAFVIIKFTLYNEIYLLDAKHVISFWNRKDTGGRKSITKQEIEEHGSLLSCGYHPRIDYISILDMVYFS
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IWS2_ARATH
Sequence: MQELDSSNDEWVKELEGENEESKFTGRRLVKKSISVPELVDEVEEDLDDFTEPADDFNDKVGKKRQRKKKDESGLEKTKKNKKQNSEEVQEMWDSITNNTNSQYGDKVVVKPPKKKDEDAEEIKKLFSLRKKKSKCDKTSMEIGMQVEQVMANLEIAVEDDVICNREGKPAINKLMKLPLLNETLSKKPLQGEFLDHGVLNLLKNWLEPLPDGSLPNINIRSAVLMILNDFRIDLDQDSRREQLIKSGLGKVIMFLSKSDEETTPNRRLANDIINKWGRIIYNKSTRYDNMFTQEELDEQRQILLRRQTKTAPKVSGTRARDFNTDIDLYELGTWTGRARAKIPTTMSMDFKIRPPSKVDINQEEEPCSKWQMEKRHKNKQQKNIRKGGMQALKLSVDGRTMLKYL
What is the function of this protein?
Transcription factor involved in RNA polymerase II (RNAPII) transcription regulation.  Involved in transcription elongation.  May function at post-recruitment and elongation steps of transcription.
What are the official names of this protein?
Protein IWS1 homolog 2, AtIWS2.
What is the protein family that this protein belongs to?
Belongs to the IWS1 family.
What are the subcellular locations of this protein?
Nucleus.