Protein: FUSA1_GIBZE
Sequence: MGSLSAVPATNGNHAALNGSASTNGQHVNGSTHVNGNHSLNGSAQVNGHSATTANLEPIAVVGMSCRLPGDATDTQKLWELITKGRSAWSKVPTDRWNQEAFHDPAAEGKPGRTSTDGGHFLKDDIKAFDASFFGVNPIEATAMDPQQRLVLEIAYEAFENAGLTLQQLSGSNTGVYVGLWASDYQEMLLRDIDFPPIYQASGVGAAIASNRVSYCFNLHGPSLTLDTGCSASLVALHQAVHSLRAGETDKCFVAGVNLQLDPQRYGYQNKLSMFSKQGKSFTFDHRAKGASGYGRGEGCSGVVLMPLSKAQKQGFPIRAVIRNSVANQDGKTNGITVPSAAAQSAAIEKAYAQVGLTPYADYVEAHGTGTTVGDPIEAKAIAKVLGAGRQSDSPLPIGSLKANIGHTESAAGLTGLVKAVLMLENNMIPPQVNYEKPNPEIDLDALNLRIPISLENKPLKRISVNSFGYGGTNAHVVVDAADAIPIKPTNTDSQETKDTLRVREQLFVLSAASEKSSQDLVLNVAKYLESKADAADTDALLSRLAYTLSRRTVMENRIGVVASDLADLVEQLTKLSSEGIPRADRQTSPRIGFVFSGQGAQYPRMGQSLLGTWPTFTSSMKRAAECVKACGSSWDLLEELLKDASESRMEDPCIAQPMSTAVQISLVDALKDLGVIPTAVVGHSSGEIAAAYCAEAISFEDAMTVSYHRGRLTSELRLENKGKAGSMIAVGASAATVKQSIDQLGTAAANRITIACHNSPASVTVSGDADVIESLKQRLDEQDIWNRLLRTGGAAYHSPQMLQIAQKYHEAIKDVSGSVPASNVAMASSVTGEDQGDKPITRDYWVHNLVSPVRFTDALKKTCVGENGTRKVDLLLELGSHFQLESPIKQTLRTFTGEAAKVHYTGSLKRGEDAQLSMLQMLRSLYLQKSPVAFWKVNAGFGATFQLLTDLPPYPFDHSKTYWHEGRVSRAYKHRQNLPHELLGTLVHDNNPQEPRWRCLLNLKDVPWLSGHIIQGQTIFPATAYLSMVFQAARQDMAARNPQASINRFILRNVTFSQALVMENNKTDLEISLSLRPQAISARKSSQQWQEFRIFSTSADDVWIEHVRGLVQVILKSEAVQEDSFVPTRITLPPHAQHIPANQFYHRARDIGVNWSAPFDNLNDIKIAAGSCIADSSFVAGPSAGACEKDYVIHPGVMDAILYHGMMGVLIFDENDKSPVVPTFIEKMIVAEQDQAKPIEEVTCHAARTESALTFDIGIFEKNHEDNMVLQAWGVVATKLPDVSIGEGRKRDLCHVPDWATYLPKTTQEYIDGLCKKSLDDRSIIPEIKALEAMTVHYVKQALASTPEDEVAEGYQRNWYNWMKTLADQEPDPEYLKAGEEDDSVSAQVARRLGPRLGDILRGTTHSLSILNEDSMLSGLYLEGGNVRCISQIATYMGELGRLNPNMKIVEVGAGTGSATLPVLQALQAPNRVLASQYDFTDISPGFFPAARELLADYEGVVQYKILNAEKTAEENGFEPNSYDVLIASNVLHATPCIDAVLENVKTMLRPGGKLILMEPTENLPHYGLVFGSLAGWWAGVDEGRTLSPMLSRSQWIETLSKNGFINNGPIFEDYPVAEGGSIHVFVSEVPVPASTEAPLDVDIVSYSGEATYTDFAERLQKNLWDRSVQSCNVSSSMSGDKLSVIMPDFVDRVAWDMDGPLFESLRSRVAGSKVIIFVMCTAKSKEKRPSGDWIYGFVRSIRYEYASVRLVTLELESGLEAGVDALKTILNSPTADLSLPLEDIELEYMEREGQIFVSRVRSEPKFDNYVSRDLGRAGSEEALFLNERPMSAELGVPGVLDTIRWVDNPEITGPVDPDCVRLQLCAASINFKDVLVASGQLEGITQMRNDCSGIVLDVGANMTDKFKVGDRVCSLYSQSFTNYPMVHGLCCHVIPDDMDFADAASIPLVWSTVYYCLITIARLQKGESILIHSAAGAVGQASIMLAHHIGAEVFVTCGNDAKVELLNTEFGIPRDHIFSSRTTVFRDKIRAMTNGNGVDVVLNSLGGEMFRESCNTLAAHGRFVEIGRKDLMENALMPMEFLLNNITFSYVDFAHILATRTALASQLLGDVMKLFASGAVQHVRQIKYPISEMASAFRLVQAGKHTGKVILTVEPDVKVQVVPSKPSPVQLKPDATYLVVGGLGGLGKRLVDWTAEKGARNIVIFSRTAQPDADAQSFLDKLVSMGVTVRVEKCDVSSEESVIEALARIQETMPPIRGLFQAAMVLHDILLEHMTVEEWCKVTAPKVQGTWNLHKYLPEDMDFFVMLSSVVSMVGTVGAGNYASACAFQDGIARYRRRLGLTAYAVNIGAIVEAGYVSENPEVAVNLRKNGLGSVAISEFLSHLGDVIQNKTEYSQSSLGILPNGNERGLGEARWANDKRLAQIFGAETQAGNKTVGGGADNVGFALQSATTFQEAQDIICDAIVKQLATILAIQSDDIIPARSLDSYGLDSLVGVELRNWIGAYLQVNLPLLVMWNTSSINELAEIVTKGSRLVKVKVEDTEEEQVDVVKD
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204).  Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204).  The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204).  The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable).  Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204).  The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase.  The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable).  The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable).  The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable).  The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase PKS6, HR-PKS PKS6, Fusaristatin A biosynthesis cluster protein PKS6.