PharMolix/UniProtQA huggingface dataset:
Protein: NQRE_VIBA3
Sequence: MEHYISLLVKSIFIENMALSFFLGMCTFLAVSKKVKTSFGLGVAVVVVLTIAVPVNNLVYTHILKENALVEGVDLSFLNFIAFIGVIAALVQILEMVLDRFFPPLYNALGIFLPLITVNCAIFGGVSFMVTRDYNFAESVVYGFGSGVGWMLAIVALAGIREKMKYSDVPPGLRGLGITFITVGLMALGFMSFSGVQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PEPF_MYCPU
Sequence: MSKEIKEYKKYSDVPKEYRFDLDYLLEGKTIDQLFDQFLEKSKKLIKIKDSKYQNIESYLESLKLEEDFNLLNNKIINYISNNISVNVVDSHFREISQKFEFMYYSFFNQIGDENQRILEHEEKITKWLLDPRLASYKKALDFVFKSKKHRLSKEVEDYLIKVSRGNIELYKVYGILTNSELDYGYALSSDGKRKIEINLSNRFNLLKDQDENIRKTTYLNWNKASAKHKETLSSLLYQHFSKLSADALARGYSSTVNSFLFEDQVDEKLLKNLYDKVSSNKKVFQKYYQNYKKFFEKKNSKQMEAWDIYLPLVVVDEKYSIEEAQDLVLKSLEPMGSEYISKVKEAFSSRWVDYLPVKNKRSGAYSIGSTHGIDKKFILMNFDGTLNSVSTLSHEMGHSMHSYFSDKTQPQSLSSYPIFLAEIASIFNELMLKDYLLEVSENLETKFHILNESILNFVGTVHRQTLWSEYEYTLYNKIDKGEPVGTYTKIDEIYEQISQKYKVSDLKNHHPEDEKNVIGVNVPHFYYHFYVYKYAIGMIVANVFYQKYKEEGKQALEFYINKFLSAGGRDWPVEILKDAGIDLYDSKIYDLAFKNFEQTIDQFVEIGNKLFK
What are the official names of this protein?
Oligoendopeptidase F homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3B family.
Protein: GLMM_ECOHS
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVEAALGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: DC4C_PSEPU
Sequence: MDEKQRYDAGMQVRRAVLGDAHVDRCLEKLNDFNGEFQEMITRHACGD
What are the official names of this protein?
4-carboxymuconolactone decarboxylase, CMD.
Protein: PTH_CLOP1
Sequence: MILIVGLGNPGKQYEQTRHNIGFDVIDYMANKYNIDVNREKFKGICGEGFIENKKVILLKPLTYMNLSGESIRELANFYKLEDDEIIVVYDDISLDIGRLRIREKGSAGGHNGIKSIIQNLGGDKFPRVKVGVGQPKDNLVNHVLGKFSKEDREHIEKVIPVVSDAIVEIVKNDAKESMNKFNGVNIE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_PSEFS
Sequence: MTRSPFRRLVFGTLRRLLYLWVRSETINQSSLTLNLDRSRPVFYVLQSPSLSELAVVDAECTKAGLPRPVLPVSVGPLMEPAAFFYLTPEPDWLGRQDKRGAPPTLTRLVNTLSEHAEENAQIIPVSVFWGQSPESESSPWKLLFADSWAVTGRLRRLLSILILGRKTRVQFSAPINLRELIEHNKGHERTVRMAQRILRVHFRNLKTAVIGPDLSHRRNLVKGLVNMPLVRQAIADEAEREKITPEKAKAQALRYGNEIASDYTYTAIRFLEVVLSWFWNKIYDGIKVNNIEGVQKVAQGYEVIYVPCHRSHIDYLLLSYLLFKNGLTPPHIAAGINLNMPVIGSLLRRGGAFFMRRTFKGNPLYTSVFNEYLHTLFTKGFPVEYFVEGGRSRTGRMLQPKTGMLAITLRSFLRSSRMPIVFVPVYIGYERVLEGRTYLGELRGASKKKESIFDIFKVVGALKQRFGQVAVNFGEPIKLAEFLDAEQPDWRSQELGPNYKPAWLNETTNRLGEQVARHLNEAAAVNPVNLVALALLSTTRLALDEQAMARQLDLYLALLRRVPYSPHTTLPDGDGLALIKHVKDMDLLSEQSDALGKILYLDEQNAVLMTYYRNNVLHIFALPALLASFFQSSSRMSRDQILRYTHALYPYLQSELFIRWSLDELDTVVDQWLEAFVEQGLLRFENNVYLRPAPSSRHFVLLTLLSKTVAQTLQRFYMAISLLLNSGQNSISAEELEDLCTIMAQRLSILHGLNAPEFFDKSLFRHFIQTLLEQDVLRRDEAGKLSYHDLLGELAEGAAKRVLPAEIRLSIRQVALHRVDGAAEAAVEPQPPKPEESR
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACKR2_RAT
Sequence: MPTIASPLPLATTGPENGSSIYDYDYLDDVTVLVCSKDEVLSFGRVFLPVVYSLIFVLGLAGNLLLLVVLLHSVPQRRRMIELYLLNLAVSNLLFVVTMPFWAISVAWHWVFGSFLCKVVSTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKTRFRNLLLIVMVWITALAVSVPEMVFVKVHQTLDGVWHCYADFGGHATIWKLYLRFQMNLLGFLFPLLAMIFFYSRIGCVLVRLRPPGQGRALRMAAALVVVFFLLWFPYNLTLFLHSLLDLHVFGNCKISHRLDYMLQVTESLAFSHCCFTPVLYAFSSHSFRQYLKAVLSVVLRRHQAPGTAHAPPCSHSESSRVTAQEDVVSMNDLGERQADISLNKGEIGNN
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3.  Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway.  Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.  By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses.  Plays a major role in the immune silencing of macrophages during the resolution of inflammation.  Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
What are the official names of this protein?
Atypical chemokine receptor 2, C-C chemokine receptor D6, CCR10-related receptor, Chemokine-binding protein 2, Chemokine-binding protein D6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: GLND_STUS1
Sequence: MPQVDPELFDRSQFQAELALKASPIAAYKKAIRQARQVLDERFRAGRDIRRLIEDRAWFVDQILRSAWSRFDWDKGADIALVAVGGYGRGELHPYSDIDLLILLDENDQEIFREPIEGFLTLLWDIGLEVGQAVRSVAECADEARADLTVITNLMESRTIAGPERLRQAMLQVTSTQQMWPSKEFFLAKRNEQRARHAKYNNTEYNLEPNVKGSPGGLRDIQTILWIARREFGTLNLQAMVDQGFITEGEHSLLTAAQEFLWKVRYGLHMLAGRAEDRLLFDHQRSLAALLGYEDSDAKLAIERFMQKYYRVVMSIAELSDLVGQHFAEVILWEGESGPIVPLNSRFQVRDGYLEVSNPAIFKRTPFAILETFVLLAQHPDIQGVRSDTIRLLRDHRYLIDDTFRQDLRNTSLFIELFKCKEGIHRNLRRMNRYGILGRYLPEFGHIVGQMQHDLFHIYTVDAHTLNVIKYLRKLTKPGVAEKYPLASKLVEKLPKPELIYIAGLYHDIAKGRGGDHSELGAVDAEQFCRRHKLPAWDTRLVVWLVENHLVMSTTAQRKDLSDPQVINDFAQRVGDETHLDYLYVLTVADINATNPTLWNSWRASLLRQLYTETKRALKRGLENPLGREEQIRQTQRAALDDLVRHGTDPDDAEQLWAQLGDDYFLRHTATDVAWHTDAIIEHPANGGPLVLIKETTQREFEGGTQIFIYAPDQHDFFAVTVAAMDQLNLNIHDARILTSSSQFTLDTYIVLEADGSPIGNNPERIEEIRSGLIAALRNPDDYLTIIQRRVPRQLKHFAFPPQVTIHNDTQRPQTILEIIAPDRPGLLARVGQLFLDFDLSVQNAKIATLGERVEDVFFVTDADNQPLSDPQLCLRLQQAIIKELQQENEQQPSPSSIVI
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: BDS7_ANEVI
Sequence: MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRAAPCFCSGKPGRGDLWILRGDCPGGYGYTSNCYKWPNICCYPH
What is the function of this protein?
Blocks Kv3 voltage-gated potassium channels.  Reduces blood pressure.
What are the official names of this protein?
Kappa-actitoxin-Avd4g, Kappa-AITX-Avd4g, Antihypertensive protein BDS-7, Blood depressing substance 7, BDS-7.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: URE3_YERPB
Sequence: MQLTPREVEKLMIYTLSDVAFKRKARGLKLNYPEAVSIITVTAMEGARDGKSVEDVMKEASKVLTKDDVMDGVADLIPNVQVEAIFTDGSRLVTVHDPIK
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 36012_ASFK5
Sequence: MLPSLQSLTKKVLAGQCLPEDQHYLLKCYDLWWNNAPITFDHNLRLIKSAGLQEGLDLNMALVKAVKENNYSLIKLFTEWGANINYGLISVNTEHTWDLCRELGAKKTLNEGDILQIFIDLKFHKTSSNIILCHEVFSDNLLLKKVNNLKMRIEIFWELREIIEKTDLLNNEFSLNTLLLKYWYAIAVRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKICMDLEEMMRIACIKDHSLSTIYYCYMLGANINQAMLTSIQYYNIENIFFCMDLGADAFEEGMALVGQEGYEPIRNILSLKIYSPATTPLPKSTDPEIIDHELKNYFSKNMMVFLTYDLR
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-12L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: ANFC_HUMAN
Sequence: MHLSQLLACALLLTLLSLRPSEAKPGAPPKVPRTPPAEELAEPQAAGGGQKKGDKAPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).  May also be vasoactive and natriuretic (PubMed:1672777).  Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034).  Binds the clearance receptor NPR3 (PubMed:11533490).
What are the official names of this protein?
C-type natriuretic peptide.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACKA_MYCS2
Sequence: MTVLVVNSGSSSLKYAVVRPASGEFLADGIIEEIGSGAVPDHDAALRAAFDELAAAGLHLEDLDLKAVGHRMVHGGKTFYKPSVVDDELIAKARELSPLAPLHNPPAIKGIEVARKLLPDLPHIAVFDTAFFHDLPAPASTYAIDRELAETWHIKRYGFHGTSHEYVSQQAAIFLDRPLESLNQIVLHLGNGASASAVAGGKAVDTSMGLTPMEGLVMGTRSGDIDPGVIMYLWRTAGMSVDDIESMLNRRSGVLGLGGASDFRKLRELIESGDEHAKLAYDVYIHRLRKYIGAYMAVLGRTDVISFTAGVGENVPPVRRDALAGLGGLGIEIDDALNSAKSDEPRLISTPDSRVTVLVVPTNEELAIARACVGVV
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2233_SHEAM
Sequence: MQFPVDTHSHTVASTHAYSTIHDYLAVAKEKGIRLFATTDHGPAMKDAPHFWHFVNLRVLPRIWNGVGILRGIEANIMNEKGEIDYFGEYLSELDLVQAGFHEPVFAPADRLTHTRAMIATMESGLVDIITHPGNPAYPIDVEAVVGAAKACNVALEINNSSFTASRKGSEENCLAIARMATKLDAQLVMGSDAHVAFDLGGFDRSLAIVDAADYPRQRLLNESPMALLHFLQQRGHQHLDELIRYFRPVL
What are the official names of this protein?
Probable phosphatase Sama_2233.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: ARP10_HUMAN
Sequence: MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPLDGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKALGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Actin-related protein 10, Actin-related protein 11, hARP11.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RLMN_NITWN
Sequence: MAEGGVPLEKTAIGTYVPPAKPSLIGLSRAEMAERLAAIGIPREQRRMRVQQLWHWMYVRGARTFAEMTSVSKDMRAELEKHVTLDRPEVVAEQISSDGTRKWLLRLPSGDDLEKPHEVECVYIPETDRGTLCVSSQVGCTLNCSFCHTGTQRLVRNLTAGEIVGQIMVARDRLNDWADRETPHGNRLVTNIVMMGMGEPLYNFDAVRDGLLIVADNEGIGISKRRITLSTSGVVPNIVRAGEEIGVMLAISLHAVRDELRDELVPLNRKYPIAELMQACRDYPAASNAKRITFEYVMLKGVNDSLDDARRLVKLLNGIHAKINLIPFNPWPGTRYECSDWDQIEKFSEYVFNAGYSSPVRTPRGRDILAACGQLKSETEKLSARERQALRAMAMTD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_HELPH
Sequence: MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCIEIAIETCKNTKTPSNSCMKVLAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQGLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFREVPNIKAIKEASGSLKRVTELHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQNKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y763_METJA
Sequence: MDEIKEYLAKILENKIKISMIAKFKSVEEYEGRIFKDLFDVEMKNLEILYEKYLIYFNEKPNIKAEVDTNADVIEILKETIELEKFLAKKLGVNFGVRQAVIHALSDDERFLYFLTKKPYF
What are the official names of this protein?
Uncharacterized protein MJ0763.
Protein: YCDX_ECOSM
Sequence: MYPVDLHMHTVASTHAYSTLSDYIAQAKQKGIKLFAITDHGPDMEDAPHHWHFINMRIWPRVVDGVGILRGIEANIKNVDGEIDCSGKMFDSLDLIIAGFHEPVFAPHDKATNTQAMIATIASGNVHIISHPGNPKYEIDVKAVAEAAAKHQVALEINNSSFLHSRKGSEDNCRAVAAAVRDAGGWVALGSDSHTAFTMGEFEECLKILDAVDFPPERILNVSPRRLLNFLESRGMAPIAEFADL
What are the official names of this protein?
Probable phosphatase YcdX.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: HIS4_ARATH
Sequence: MEATAAPFSSIVSSRQNFSSSSSIRASSPASLFLSQKSIGNVNRKFKSPRSLSVRASSTSDSVVTLLDYGAGNVRSIRNALRHLGFSIKDVQTPGDILNADRLIFPGVGAFAPAMDVLNRTGMAEALCKYIENDRPFLGICLGLQLLFDSSEENGPVKGLGVIPGIVGRFDASAGIRVPHIGWNALQVGKDSEILDDVGNRHVYFVHSYRAIPSDENKDWISSTCNYGESFISSIRRGNVHAVQFHPEKSGEVGLSVLRRFLHPKLPATQKPMEGKASKLAKRVIACLDVRTNDKGDLVVTKGDQYDVREQSNENEVRNLGKPVDLAGQYYKDGADEISFLNITGFRDFPLGDLPMIQVLRQTSKNVFVPLTVGGGIRDFTDASGRYYSSLEVAAEYFRSGADKISIGSDAVSAAEEFIKSGVKTGKSSLEQISRVYGNQAVVVSIDPRRVYVNHPDDVPYKVIRVTNPGPNGEEYAWYQCTVSGGREGRPIGAFELAKAVEELGAGEILLNCIDCDGQGKGFDIDLVKLISDSVGIPVIASSGAGTPDHFSEVFEKTNASAALAAGIFHRKEVPIQSVKEHLQEERIEVRI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR.  The ammonia is channeled to the active site of the cyclase domain.
What are the official names of this protein?
Imidazole glycerol phosphate synthase hisHF, chloroplastic, IGP synthase, IGPS, ImGP synthase, Protein HISTIDINE BIOSYNTHESIS 4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EZRA_STRP7
Sequence: MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVAENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: P80_DICDI
Sequence: MKVISGLLFFILISCSLFLVQGQVDCVTNSSDASCTNFQYPLANITADINNLCGSMPYMPVCTIQQSCNQESSTSGICDPFSILGDSCLHDMPGMSGCNNFKKLCASGSVVEQCSTVDSVTDLPTTMKMWANIKSICNEMTMTGCEKCTILNATCDVLTVYSTLCLAMPEMGQCANWTQMCASSGNMASSPISSGICTDEPTPATDCFTNPSDPSCADYVYTAANANADILNLCKSMPYMTVCSIQKSCNQESSTSGICAPFSILGDSCLHDMPGMNGCSNFKKLCASGSVVEQCSSVDSISNLPTTMQLFAGIKSICTEMAMDGCEKCSGNSPTTTCDVLPVYSSLCMAMPDMSQCANWTKMCSSSGQLYNSQITSDYCVASVADAVPIMRMYFHTGILDYILFKSWVPRTDRQFAGSWFAIFFFAIFFELEKTLRSILEKRWTPNKKDSEDNNLINSSFLSGSYPKFSYRDIIRGCLHAIELTCSYALMLVAMTFNVALFFAVIAGVLVGNILFGRYRNYTPRVTCCE
What are the official names of this protein?
Protein P80, Endosomal membrane protein.
What is the protein family that this protein belongs to?
Belongs to the SLC31A transporter family.
What are the subcellular locations of this protein?
Late endosome membrane; Single-pass membrane protein.
Protein: RS27_HOMAM
Sequence: MPLAKDLLHPSPSEEKRKCKLKRLVQHPNSYFMDVKCPGCFKISTVFSHAQTVVACVGCATVLCQPTGGKAKLTDGCSFRKKQN
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Required for proper rRNA processing and maturation of 18S rRNAs.
What are the official names of this protein?
40S ribosomal protein S27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: MSH3_LODEL
Sequence: MASKKQSTISLFFSSQTRKSPGRDAKKNDISSSPFNAASSTNNSIGSTPRVSPIAKFQYNKSTSTLHENTNPRVKRVSTLNVDVEKEHKKIKRARSTKLTPLESQILQLLSEHPDKILLIQVGYKYKVYGEDARHVARCLNIMFISSSTDPTFSYCSFPENRLHINLQRILNTGVKVGVVKQMESAIIKEVDKIGKSGDLMKRELTGVYTRGTYMNDEFIDSGVNSPEQEELGYIVCVNEISRYQFAIVAIQPLTGEIIYDDFTDDVSHDELETRLLYLRPSEVLLLGCGGNESNNNNNNNSNNSSNNNDNGTDADAQNQTSTLQCFQKLVNHNIKIERKPKGLNNLKAVLNAAALNFYRELLEPVQVCVSELVKYLEEFNLSNIFTVIENVSKFDSKKTMILPASTMLSLEIFQNSENSTTKGTLFSLLNHTKTPFGMRLLESWVSHPLIDKDKIEERYQAVEDLSTGSHFNDCLSRLLQKIGKNLDLESIAIKIHYSTTTRSLATKINRKDIFMMLLMYQSALQFVSQFEKTIKASNLSPLLKRVLDNLLQLANTDTVDRFMDMINPSYLLGEQQNLHQSSRSTREQKVKFFNLNNGFEEINRELAEIMNVKMLLEEELVKVKKLLQRPQLNYVTSNGEPYLIEVRNGKAVESLPIDFIKINGTTTVSRFRSKEIAHLYKMKQYHEEVLNNRCDEAFNTFLNELDSHYGFFQGITKNLAVLDCLLSLAAVSNSNSNTHVKPNLSDELIIDVKNARHPIIEHLRDGYVANDIDIRYDSNRVLVITGPNMGGKSSYVKMVALLIIMTQIGCYIPCEAATIGIFDSILIRMGASDNLLKGRSTFMTEMLECSNIIQKLTPRSLVILDEIGRGTGSIDGYSLAYAILRYLVESKLKPIVLCITHYTGLLSETEDEKFDKDAKDENLDTGDDVVKSYYMGYEEITQPGQVFPEIVFLYNLCPGVSNSYGLQVAKMAGLPKKVLLEAYLMSSVTDFD
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATG7_PICGU
Sequence: MIMTELRDLVGKPLKYVPTRSFVESSFFKALSDLKLNQLKLNTDTVSISGFMNHPKNLTKFQDYPILNLDFSSFELASSASSAASDENVEYKGTLLNVNTIEEFKAINKSDLLKQWGSLIYKSITEGDTTYRSVNQFFVLTFSDLKKYKFYYWFAYPSLQSQWTVKECKEAPSFEDETRKYLDTQEELEFFFAREQEEFCGLSKFLNGSKKVNEHSTFVFVDSCRHPGLYPGWQLKNFLYILARQGMREIRLFVYRYDGTSIMMKLQLDSIPNDIKFMGWERTKDDKLGPKLADLGSLIDPIQLADQAVDLNLKLMKWRISPQLNLEKVAQQKVLLLGSGTLGSYVARALMGWGVRHITFVDNGRVSYSNPVRQPLFGFNDCFSDEGLGRWKAPRAAEALKEIFPGVNSSAYNLEVPMIGHPVENEQSAKANYETLERLVDENDAIFLLMDSRESRWLPTLLGMAKNKLVINAALGFDSFLVMRHGTTTNNLGCYYCNDVVAPSDSLSDRTLDQMCTVTRPGGALMASALAVELLVSVLQHPEGAEADAKEHSFFGEVPHQIRGFLHNFSQTKLYAPKYTHCSACSQPVVDSFRSQGWDFVKNCLNDTKHLERVCGLEEVQREAERASEALLEQAAGLDLSDEEWL
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.