Protein: MICA3_MOUSE
Sequence: MEERKQETTNQAHVLFDRFVQATTCKGTLRAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLVQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYTDTELLLSRENVDQEALLNYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNININFLRPSQVRHLYDSGETKDIHLEMENMVNPRTTPKLTRNESVARSSKLLGWCQRQTEGYSGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLSSSDTLDLNAEEKAVLIASTKSPISFLSKLGQTISRKRSPKDKKEKDSDGAGKRRKTSQSEEEEPPRSYKGERPTLVSTLTDRRMDAAVGNQNKVKYMATQLLAKFEENAPAQSTGVRRQGSIKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEVKGALQDGPTADANGLASVAASSAERSPGTSMNGLEEPSIAKRLRGTPERIELENYRRSVRQVEELEEVPEETQAEHNLSSVLDKGTEEDVASSSSESEMEEEEEEDDEDDHLPTSDLGGVPWKEAVRIHALLKGRSEEELEASKNFEPEEEEEEEEYEEEDEEYEEEEEEESSEAGNKRLQQIITAADPLAIQADVHWTHIREREAEERMLPTSESSTSRAPLDEDDLEEDADSEPAETEGEAAEDGDPGDTGAELDDQHWSDDIPSDAEAEHRLQSQAKVKAELELRVSENEEEKPSDAPKQEERGTSQVSSPSQPPEKQVGVFSPARSPGTEEAKSPLATKVKSPEEPLFPTPLLLREKPKAEVPEEQKAVLSPIRSQPVALPEARSPTSPTSLQPESLLAPPTPPTPPPTQLPICSQPQPSSDASIPSPTKSPIRFQPVPAKTSTPLTPLPVKSQGDPKDRLSGPLAVEEVLKRSDLVEEFWMKSAEIRRSLGLTPVDRSKGSEPSLPSPASKPISLKSYSVDKSPQDEGLCLLKPPSVPKRLGLPKSAGDQPPLLTPKSPSDKELRSSQEERRDLSSSSGLGLHDSSSNMKTLGSQSFNTSDSTMLTPPSSPPPPPPPNEEPATLRRKPHQTFERREASIIPPPTPASFMRPPREPAQPPREEVRKSFVESVDEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWSRSEKLQAKENGRLPPLEQDVPPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMAKQLSRMQAMEMVSSRSHTAQSQGKELGSESTRHPSLRGTQEPTLKHEATSEEILSPPSDSGGPDGSVTSSEGSSGKSKKRSSLFSPRRNKKEKKTKGEARPPEKPSPGLPEDVVAKPKSLWKSVFSGYKKDKKKKSDEKSCSSTPSSGATVDSGQRRASPMVRAELQLRRQLSFSEDSDLSSDDILERSSQKSKREPRTYTEEELSAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLEQVEEKQRQLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEGELSEEKKILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAAMLCKGFSLDWS
What is the function of this protein?
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization.  In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2).  Seems to act as Rab effector protein and play a role in vesicle trafficking.  Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles.  Required for cytokinesis.  Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity.  Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
What are the official names of this protein?
[F-actin]-monooxygenase MICAL3, Molecule interacting with CasL protein 3, MICAL-3.
What is the protein family that this protein belongs to?
Belongs to the Mical family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Midbody. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=Mainly localizes in the nucleus.