PharMolix/UniProtQA huggingface dataset:
Protein: SKG3_YEAST
Sequence: MKRIFSGVKSPKLSAPPKVFKNDESPSTPSSPKFDQGLRSLSASASRLFSNSISTPGSPTLDLPQEHSINGDISPELVPIVTLLSAQAHRRYHYGIFLILHDLKTDGTPAARQWEECYGVLLGTQLALWDAKELSDSKNNKNTSTMKKAASRPSFINFTDASVRSLDANDQVIIASENEKTKKDLDNVLVVSTTLKNRYFLKFKNSKSFKTWNAAIRLSLFEFTALQEAYTGSFLSSRGVKLGDIKVVMADTKFTYEDWVSVRFGTGMPWKRCYAVISPQSGKKKKNSKGSICFYENNKKTKKSNIMTTVVDARALYAVYPSSPILIDTSTIIKLEGFVSFDKSEEPQETNLFIMPEKHQGVPGYDTIIRFLIPAMNAFYLYGRPKGLIANRTDPDSLLFALPTLPHIYYLQVDDVLSLTKDKNYIHWSAADWRNNIVQVLQKKLSKGYKGCGNKTVSVSSGMMKSPAISSAELFEGYDSLPERQMESPQKSKMKSPTLASTDDINSASASVNSHATSVKQTELFVTDNSSKINDSVSAQSSVTTNFKDTFTTPMTSGMLNHENSERSFGSGLKLKITDSNLENMEDVEAKSANEFSTTPEDKHIHLANAAELSALYDKYSTSPFGKSEANSSPKPQKLEVKDRSKNENRSPYERYVGTSAESKTFEIGNVRESKSTINTSLSSPLRVEDSRRSKNEDLGSLKEFEELSQKISNMGMANISSEALSDTAENSSFVTDLNLNINNSSSVNLNEEQRVPDFGEENVFDPDYMEQNQMLETESRYTTDEFDFSDNQDAASSNYSNGQTNRTVTETLSASDRNDKIPHSSLFTNLNQLTSNGGNYQDREDFSGDQINKPQQSQPLHVKGPQTSSFGYRNSSANSSQPQAPYPVGRPLGKIRTGPLTVQPMQQGGNSSMYSFQSSQHRFHSSQQRQNQSLSFRNNTYGSGNNQNTFHPSPQLQQQPQNMRYLNNKLPINDRSPIPQTQHHVPDGRPSLHINTTNRTNPLTAQSGFSQFMPPNSTSTNPYSS
What is the function of this protein?
May play a role in cell wall integrity.
What are the official names of this protein?
Protein SKG3, Suppressor of lethality of KEX2-GAS1 double null mutant protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Bud neck. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPA_ACEWD
Sequence: MNLRPEEISQIIKNEIERYEDKLEVVDVGTVIQVGDGVARVHGLENAMAGELLAFPNEVYGMVLNLEEDNVGCVLLGYDDDIVEGDIVRCTGRIVEVPVGEAMIGRVVNALGFPVDGKGPIVTDHRRPVEVKAAGVIERESVNQPIQTGYKAIDSMIPIGRGQRELIIGDRQTGKTALAIDTIINQKGEDVICIYVAIGQKDSTVAQIVGQLEENNAMDYTIIVSAGAAQLAPLQYIAPYSGVTMAEYFMNEQQKDVLIIYDDLSKHAVAYRAMSLILRRPPGREAYPGDVFYLHSRLLERAAKLKAGGSITALPIIETQAGDVSAYIPTNVISITDGQIFLEAELFRSGIRPAVNPGISVSRVGGSAQIKSMKKVAGPLRIEYAQYRELASFAQFGSDLDDETKAQLAKGERIVEILKQDQYDPMNVEDQVLILYAATNGFLLDIEVKDIREFEKGLIKFAQKKYPEIMTKVKGKDGLSDEVVAAFAECIEAYKKVFSKSV
What is the function of this protein?
Produces ATP from ADP in the presence of a sodium ion gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, sodium ion specific, Na(+)-translocating ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPG_MYCTU
Sequence: MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESARPYAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEELFSLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDAFLLGTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRTLYSFEPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALTLMANRERQAQITQEISEIVGGANALAEAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TIM14_DEBHA
Sequence: MAPFNMDIPTLAIPGDRNQSQAIELSQQAQQPQQPQQSQQAYTGHLQRKQADEGSAEYYFDKGCEWMGNHPWMTGMGVLGVAYFASGFVKSKQPGINGKAFVKGPFGQKMTPKEALQILNLKETNLSQAKLKEQHRKLMMANHPDKGGSSYLATKVNEAKDILEKRGGLKKK
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, Presequence translocated-associated motor subunit PAM18.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MB12A_CHICK
Sequence: MAAEEEAAPLSGVGWAAGPESAPAGWSVITISVEGSAANLGKGFGHKGGYLCVSTAAPGSAGPVVTDVQVLSDRNPQPAGYSRAPEFPEPRSGVSRKKRLYVRLQPRGAAETAVFDIKLSGKSRAVPQYMKIGEIGSFAIWCKKGALPQCSPPPVPKPRTVSLGLKQLSLADSEQQAPGKPVAQSGSRHASFTLHNSADDGSSIYNLSAMDGVPFTLHPKFERSPKSDSSAILTDLTVKSLADIEKEYNYTFVVERTAAARLPPSIC
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
What are the official names of this protein?
Multivesicular body subunit 12A, ESCRT-I complex subunit MVB12A, Protein FAM125A.
What is the protein family that this protein belongs to?
Belongs to the MVB12 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with F-actin.
Protein: CBPA2_RAT
Sequence: MRLTLLLAALLGYIYCQETFVGDQVLEIIPSHEEQIRTLLQLEAEEHLELDFWKSPTIPGETVHVRVPFASIQAVKVFLESQGIDYSIMIEDVQVLLDQEREEMLFNQQRERGGNFNFEAYHTLEEIYQEMDNLVAENPGLVSKVNLGSSFENRPMNVLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKIASDYGTDPAITSLLNTLDIFLLPVTNPDGYVFSQTTNRMWRKTRSKRSGSGCVGVDPNRNWDANFGGPGASSSPCSDSYHGPKPNSEVEVKSIVDFIKSHGKVKAFITLHSYSQLLMFPYGYKCTKPDDFNELDEVAQKAAQALKRLHGTSYKVGPICSVIYQASGGSIDWAYDLGIKYSFAFELRDTAFYGFLLPAKQILPTAEETWLGLKTIMEHVRDHPY
What are the official names of this protein?
Carboxypeptidase A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL12A_RAT
Sequence: MCQSRYLLFLATLVLLNHLTSARVIPVSGPAKCLNQSQNLLKTTDDMVRTAREKLKHYSCTAGDIDHEDITRDKTSTLEACLPLELHKNESCLATKETSSIIRGSCLPPQKTSLMMTLCLGSIYEDLKMYQSEFQAINAALQSHNHQQITLDRNMLMAIDELMRSLNHSGETLHQKAPMGEADPYRVKMKLCILLHAFSTRVMTINRVMNYLSSS
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CREM_HUMAN
Sequence: MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
What is the function of this protein?
May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
What are the official names of this protein?
cAMP-responsive element modulator, Inducible cAMP early repressor, ICER.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm. Nucleus.
Protein: RUVC_DINSH
Sequence: MRVLGIDPGLRNLGWGVISVQGSRLRHVANGQIRSEGSELAQRLLSLYRQLTEVVAGHAPDAAAVEHTFVNKDATGTLKLGQARGIALLVPAAAGLEVAEYAPNHVKKSVVGVGHAAKEQVQHMVKLQLPGVVLAGADAADALAIAICHAHHLQSRGKVVAVNRTVAAPDGLRSVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: PROA_NOSP7
Sequence: MTTFDIGSPLIAIAQKTRKAASKLAILSTEAKNQAIIAIAQALESAKDEILQANIADCEAANAEGIPKPLYKRLQLDEHKLRDAIVGVQDVGKLDDPVGKVQIHRELDTGLILKRITCPLGVLGIIFEARPEAAIQIASLAIKSGNGVILKCGKEAVRSCEAIVKAIKQGLSHTAVNPDTVQLLTTREETLELLKLDKYVDLIIPRGSNSFVRFVQENTRIPVLGHADGICHLYIDKAADISKAVPITVDAKAQYPAVCNAIETLLVHQSIATEFLPKVADALQERHVELRGDKRTLKILPNIVSATEIDWETEYSDYILSIKIVDSIEDAIAHINEYGSRHTDAIITEDSTSVETFFGLVNSANIFHNCSTRFADGFRYGFGAEVGISTQQMPPRGPVGLEGLVTYKYQMTGDGHIVATYTGANAKAFTHRDLV
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_BRADU
Sequence: MTSKSTFVLGHRHLLGIEGLSAADITGLLDLSEEYVELNRQVDKKRTVLRGRTQVNLFFEASTRTQSSFELAGKRLGADVMNMSVSSSSIKKGETLVDTAMTLNAMHPDILVVRHHASGAVELLARKVDGSVINAGDGAHEHPTQALLDALTIRRNKGRIEGLVVAICGDVLHSRVARSNIILLNTMGARVRVVGPSTLLPPGIERMGVEVARDMREGLNGADIVMMLRLQRERMNGSFVPSTSEYFNYFGLDQKKLGYAKPDALVMHPGPMNRGVEIDTAVADGAQSLIREQVEMGVAVRMAVLEALARNLPNA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: POL_SIVV3
Sequence: KEALVIWGELPTLELPVEREVWEQWWADYWQVSWIPEWDFVSTPPWLKLWYTLTKEPLAKEDVYYVDGACNRNSREGKAGYITQYGKQRVEKLENTTNQQ
What is the function of this protein?
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme.  RNase H activity is associated with the reverse transcriptase.
What are the official names of this protein?
Pol polyprotein.
What is the protein family that this protein belongs to?
Belongs to the retroviral Pol polyprotein family.
Protein: YIDC_STRAW
Sequence: MDTIASLFSFITIPVSWVIVQFHSVYGKVFGADTGWAWGLSIVSLVILIRICLIPLFVKQIKATRAMQTLQPEMKKIQERYKNDKQRQSEEMMKLYKESGTNPLSSCLPILAQSPFFFALYHVLNGIATGKTIGVIDDQLLASARKAHIFGAPLAAKFTDSADKVTQLGATLMDVRVVTAIMIVLMSASQFYTQRQLMTKNVDTTVKTPFMQQQKMLMYVFPVMFAIFGINFPVGVLVYWLTTNVWTMGQQMYVIRNNPTPGSKAQAAFLERLQKHVLHHGKTRSRGQRAVVKAIVAKGRDRNEFERKFINALTKAGLAAQSDGTIGKGEATAVAETEDGTQTTGGAPRRQQPKRQSKSQRQSGSAKAAGESEPKSTPLSLSKSDEPDDAKPAAKPAGGANKPSTGTRSKAQSGQRKGPQRPKSPSKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSPD2_MOUSE
Sequence: MAENNAQNKAKLISETRRRFEAEYVTEKSEKYDSRDVERLQQDDNWVESYLYWRHNVVDETLKMLDESFQWRKEFSVNDLSESSIPRWLLELGGIYLHGYDKEGNKLFWIRVKYHIKDQKTIMDKKKLIAFWLERYAKRENGKPITVMFDMSETGLNSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWIMNAAFKIVKSWLGPEAVSLLKFTSKNEIQEYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPIASEDETSSKEDIEGDGKETLETISNEEPPALSEKSNPTESVSKKDENEKVDSKTKTFKKPLSVFKGPLLHISPAEELYFGSIESGEKKTLIVLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASIDIIVSPHGGLTVSAQDRFLIMAAEMEQSSGTGPAELSQFWKEVPRNKVMEHRLRCHTVESSKPNSLMLKDSISTMSDKTSEDLYLQLNRLLESNRKLEDQLQRSIWFQQLLLALTMVLLDFVVSFFYSLYN
What is the function of this protein?
Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif.  Might have a more important role in endoplasmic reticulum and endosomes contacts.  Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
What are the official names of this protein?
Motile sperm domain-containing protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif.
Protein: CB4C_ARATH
Sequence: MATTTAAAASGIFGIRIQDPRPGTGRVQARFGFSFGKKKPAPPPKKSRQVQDDGDRLVWFPGANPPEWLDGSMIGDRGFDPFGLGKPAEYLQYDFDGLDQNLAKNVAGDIIGIIQESSEIKPTPFQPYTEVFGIQRFRECELIHGRWAMLGTLGAIAVEALTGIAWQDAGKVELVEGSSYLGQPLPFSLTTLIWIEVLVVGYIEFQRNSELDPEKRIYPGGYFDPLGLAADPEKLDTLKLAEIKHSRLAMVAFLIFALQAAFTGKGPVSFLATFNN
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein CP29.3, chloroplastic, LHCB4.3, LHCII protein 4.3.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: CYAY_NEIMA
Sequence: MMTESEFIRASEALFEHIEDQIDENGWDFDCRFAGNVLTIEAGDGTQIIVNRHTPNQELWIAAKSGGYHFAEQNGKWLATRDSRDFYDVLNEALSAASGEAVKIAEL
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: H33_GOSHI
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: IAA6_ORYSJ
Sequence: MEEGSNKREGLPPQLLDLIPDEKEWKLREALGLGRSRNAGFDGEEDKKLDLKLGLPGFIEDDEAETLRDYRLQQESPSLSLSFFPKHSKTTSSTTTTTGAKRGFIDTVEDKTEGYNDQKQQARAGCGKELAVEEMIAAVSERKKGCCPPPPPPHGAPATPARNRPQTQGRGAAAPVVGWPPIRSFRRNLASSSSSKHSPEPQNDNANAKVTLTCKKNPLVKINMDGIPIGRKIDLAAYNSYDGLSSAVKQLFHGFLQAQKDQTNAQIAQQGADDKIFYQLLDGSGEYTLVYEDSEGDRMLVGDVPWKVFVSTAKRLRVLRSSELSHTLIGATARV
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
What are the official names of this protein?
Auxin-responsive protein IAA6, Indoleacetic acid-induced protein 6.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PFKAL_HUMAN
Sequence: MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583).  Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species.  Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, liver type, ATP-PFK, PFK-L, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B, PFK-B, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
Protein: MVL_MICVR
Sequence: MASYKVNIPAGPLWSNAEAQQVGPKIAAAHQGNFTGQWTTVVESAMSVVEVELQVENTGIHEFKTDVLAGPLWSNDEAQKLGPQIAASYGAEFTGQWRTIVEGVMSVIQIKYTF
What is the function of this protein?
Unexpectedly for a lectin, one of the 2 oligomannose binding sites of MVL can catalyze the cleavage of chitin fragments (such as chitotriose, i. e.  GlcNAc(3) or GlcNAc-beta-(1->4)-GlcNAcbeta-(1->4)-GlcNAc, and chitotetraose, i. e.  GlcNAc(4)) to GlcNAc.  This weak beta-1,4-glycosidase activity is restricted to the C-terminal carbohydrate-binding site.  Does not cleave Man(3)GlcNAc(2) or the tetrasaccharide Man(2)A.
What are the official names of this protein?
Lectin MVL, Mannan-binding lectin, N-acetyl-beta-glucosaminidase, Oligomannoside-binding lectin.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_EXISA
Sequence: MTNKLQVSKRELRPRSLRTKLRKEGKALGVVYGYKVDSTPIVFDEMDLRKILRDHGDNALIELHYDGNKINTLVHGSETDPFTNFYQHVEFMAVKMDEETEVEADIVLVGDAKGVKEGGYLAQSLYKVTVAATPANIPERIELDVSELGIGDSVTVADLPEEKSYKIVSEPDMHIASVNEPVAEVEEEESEEGSTEEEASEGASEETEESTEDKE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: NUOI_BORPA
Sequence: MEAIKDFFGSLLLTELFKGLRLTGKYFFKRKVTLRYPMEKTPTSARFRGLHALRRYPNGEERCIACKLCEAVCPALAITIESEQRDDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETHIHEYHGEKRGDLYFTKDMLLAVGDRYEAEIARRRAEDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KGUA_RHOJR
Sequence: MVADAQVSESKTAVRRGRLVVLAGPSAVGKSSVVRLLRERMPELVFSVSATTRDPRPGEVDGKDYRFTSRDEFQRMIESGELLEWAEIHGGLQLSGTPAAPVRRAIEQGKPVLVEVDLAGARAVRAAMPEALLVFMAPPSWDVLVERLTGRGTESAEVVERRLATARVELEAQDEFDEVIVNEDVSRSCDELVSLLVGRPEQSESTH
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2BS2_LYTPI
Sequence: MPRSPSKSSPRKGSPRKGSPRKGSPKRGGKGAKRAGKGGRRRNVVKRRRRRRESYGSYIYRVLKQVHPDTGISSRGMSVMNSFVNDVFERIAGEASRLCQANRRRTISSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTTSR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.2, sperm.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.