PharMolix/UniProtQA huggingface dataset:
Protein: RSGA_ECO81
Sequence: MSKNKLSKGQQRRVNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVESADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGMEFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQKEILTNDVSDNSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAVEEGKIAETRFENYHRILESMAQVKTRKNFSDTDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PD_CHLPN
Sequence: MTNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFARREKSNELFRQEMKQAVIQFSPSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDLDKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQGKPWSRVIIEKPFGRDLDSAKQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSETIGIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSEGSSIVRGQYGPGTVQGVSVLGYREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGKRLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRIQPDEGVALKFNCKVPGTNNIVRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQDSSPSFPNYPAGSSGPKEADALIERDGRSWRPL
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: FABA_STRMK
Sequence: MTRLHAFNREQLLASARGELFGTAAGRLPNDPMLMFDRITDIREDGGPHGKGMVRAELDIRPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWLGAPGKGRALGCGEVKFTGQVLPEAKLVRYEIDISRVINRKLVMAQSDARMYVDDREIYSARDLRVGLFTETGSF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YORT_BACSU
Sequence: MERFIKRLSASCESTIHHKVYQIMNEAKTEFEKVLKKLK
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YorT.
Protein: RIMP_STRP2
Sequence: MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVDKPEGITLNDTADLTEIISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGKYIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVRIPYSLVSKARLAVKL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y870A_HAEIN
Sequence: MVLYFYNKINRSFGLMILLYFFRSGGLAFRISELFLIFSIPLFALLINELSGVNRVLMFFILVYYISIVFLRRIYVHVVFGVNTFLPYKPIFDSYL
What are the official names of this protein?
Uncharacterized protein HI_0870.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACHA6_RAT
Sequence: MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-6.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: CLPP_BORPD
Sequence: MQRFTDFYASMHGGASVTPTGLGYIPMVIEQSGRGERAYDIYSRLLRERLIFLVGPVNDNTANLIVAQLLFLESENPDKDISLYINSPGGSVYAGMAIYDTMQFVKPDVSTLCTGLAASMGAFLLAAGKKGKRFTLPNSRIMIHQPSGGAQGQASDIQIQAREILDLRERLNRILAENTGQPVERIAVDTERDNFMSAEDAVSYGLVDKVLASRSEG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PET8_YEAST
Sequence: MNTFFLSLLSGAAAGTSTDLVFFPIDTIKTRLQAKGGFFANGGYKGIYRGLGSAVVASAPGASLFFISYDYMKVKSRPYISKLYSQGSEQLIDTTTHMLSSSIGEICACLVRVPAEVVKQRTQVHSTNSSWQTLQSILRNDNKEGLRKNLYRGWSTTIMREIPFTCIQFPLYEYLKKTWAKANGQSQVEPWKGAICGSIAGGIAAATTTPLDFLKTRLMLNKTTASLGSVIIRIYREEGPAVFFSGVGPRTMWISAGGAIFLGMYETVHSLLSKSFPTAGEMRA
What are the official names of this protein?
Putative mitochondrial carrier protein PET8.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZN689_MOUSE
Sequence: MAPPSAPLLLRAVGEAGPTRKRGRRPRALKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALGCAGPKPALISWLERNTDDWEPAALDPQEYRRWVTFQRKTRSKQKTEEKDVFPPKEAPRKGKRGRKPSKPRLIPRQTSGGPICPDCGCTFPDHLALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTHTGEKPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECSRRFRQRTALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLSQHQLLHTGEKPFPCLECGRCFRQRWSLAVHKCCPNTPNGSPRPLIGGPSQRSSAL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 689.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VP31_BPPRD
Sequence: MNVNNPNQMTVTPVYNGCDSGEGPQSVRGYFDAVAGENVKYDLTYLADTQGFTGVQCIYIDNAENDGAFEIDVEETGQRIKCPAGKQGYFPLLVPGRAKFVARHLGSGKKSVPLFFLNFTIAQGVW
What is the function of this protein?
In association with P2 and trimeric P5, forms the spike complexes located at the 5-fold vertices of the capsid.  Essential for viral infectivity.
What are the official names of this protein?
Penton protein P31, GpC, Protein C.
What are the subcellular locations of this protein?
Virion.
Protein: RL9_PROM9
Sequence: MAKRVKVALTESIASLGKEGDLVEVAPGYARNFLLPYGKAMNVTPAVLKQIERKKEKEKIAADKLKQEALDFQTALSTIGRFTIKKQVGEDGVLFGTVTNGDVAEAIEAATKKEIDRRNITVPDIHNLGSFTAKIKLHPDVNAEVNIEVTS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TRPA1_ARATH
Sequence: MDLLKTPSSTVGLSETFARLKSQGKVALIPYITAGDPDLSTTAKALKVLDSCGSDIIELGVPYSDPLADGPAIQAAARRSLLKGTNFNSIISMLKEVIPQLSCPIALFTYYNPILRRGVENYMTVIKNAGVHGLLVPDVPLEETETLRNEARKHQIELVLLTTPTTPKERMNAIVEASEGFIYLVSSVGVTGTRESVNEKVQSLLQQIKEATSKPVAVGFGISKPEHVKQVAEWGADGVIVGSAMVKILGESESPEQGLKELEFFTKSLKSALVS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).  Contributes to the tryptophan-independent indole biosynthesis, and possibly to auxin production.
What are the official names of this protein?
Tryptophan synthase alpha chain, Indole synthase, Indole-3-glycerol-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2640_MYCLE
Sequence: MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMADDKDAFAEFVTAHRL
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: YNL5_YEAS7
Sequence: MKANGLDNDPARTRMERTDIDSEHPEAQPLLNNNHRTLGAGSANGPAVNEGRDIESDGFIKDSLFQIRKGYRIFIHNSKWILNILILINTIWLVTTLISDFFFNINILFGFSNRYASFNDLTLIFISIIANSFNLWFNKLGLYSALDYSLNVTLCVLTLFNLALTYLIKYTRQRIGFVGTFTYLWTSFSFFIGAILDWYLLFYNNSINEPLEERRIDDANISTFNENHTNSTENRDRSQYGSGSPTPTHRSQLVQNKHTLTEWVSIGFRNTIKFLILIFFALFTLNTLLTTLDTYRLTHKLPITVQSPSYEAFHYVDAAKTYQLHITCYGDVFDQENNTDLSENKKQPIILFEHGGYDTGYLSATWIEELYHLDKIQRYCLYDRPGYGLSDSPPAPISIAMVAESLRYALIKDAKIKGPFTTVGYDLGGLFTRVFTAKNVDIVDSMMLVESWHEELLLKNYIQRLLPPGRGDGDDGDDGNGNDGDGRNHDKTWLPSEIERHNEFRLWWKGIWSSLGWRLQTSWLLAHHGSKERIYGRDMKYQGRFLRSKFLESVTSSILSYRDVTNNAESLQNVKTSIVSSKEMVKKSALWGDWQRDLTKISHKTQEWKIVEGGHEIYKYGLGKQQTQEVLLRLIGELGKLTED
What are the official names of this protein?
Uncharacterized vacuolar membrane protein SCY_4679.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: EFP_METRJ
Sequence: MKVIASTLRKGNVVEKDGKLYVILFAENIHPGKGTPVTQLDMRRITDGVKVSERYRTTEQVERAFVEDREHTFLYSDGEGFHFMNPENYEQIAVPEDVVGDAAPYLQEGMAVMLSVHNGVPLTIELPQRVTLEVAETEPVLKGQTASSSYKPATLSNGVRTTVPPHIAAGTRVVVMTADGSYVERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUGFT_MYCBO
Sequence: MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA
What is the function of this protein?
Sugar N-formyltransferase that catalyzes the conversion of dTDP-4-amino-4,6-dideoxyglucose into dTDP-4-formamido-4,6-dideoxyglucose using N(10)-formyltetrahydrofolate as the carbon source.  Plays a role in virulence.
What are the official names of this protein?
dTDP-4-amino-4,6-dideoxyglucose formyltransferase, dTDP-Qui4N formyltransferase, Sugar N-formyltransferase BQ2027_MB3438C.
What is the protein family that this protein belongs to?
Belongs to the dTDP-Qui4N formyltransferase family.
Protein: YNTX_RHIET
Sequence: GNKVILSDGPNVFTGCKLTVHMQTGQAELESCGGRVQIQLDPKSQPNAQQQKQN
What are the official names of this protein?
Uncharacterized protein in rpoN-linked probable transport protein 5'region.
Protein: PLSY_CUPNH
Sequence: MANLLFALAAYLIGSVSFAVVVSKLMGLPDPHSYGSGNPGATNVLRTGNKKAAILTLIGDALKGWLAVWLAARFGPAYGLNETGLAMVALAVFLGHLFPVYHRFAGGKGVATAAGILLAIDPILGLGTLATWLIIAFFFRYSSLAALVAAIFAPFFHVLMNGVDVMTGAIFVISVLLIARHRQNIAKLLAGKESRIGEKKKV
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPH_LISMO
Sequence: MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVDGANREEILDKITTGTVIFTAHGVSPSVKAKAVAKGLTTIDATCPDVLHTYNLILEKQAAGYEIIYIGKKGHPEPEGAYGTAPDVVHLVETKADIDALSLLSDKIFVTNQTTMSKWDVADLMHYIKGKFPKAIQHQEICMATQVRQEAVALQAKDADLTIVVGDPRSNNTARLAQVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKTTWKREHNQDFERILPKTKNKYMAEKRSQRLAHLKNGGS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PCKA_SHEB5
Sequence: MADGLNRVHFNPSTAQLVEFALLRGEGELTANGALVAKTGARSGRSPGDRFIVREPSSEAEIEWGPVNQAFDPGAFEGLWARVEAYLADKELFVSDLEVGADTEHYQPVRVTTQYAWHQLFARNLFIIPEEFNRKNKPVWQIINAPDFVCDPARDGTNSDATVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAQGVLPMHCSANVGKDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAPGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVVMDEHRVPNYKDSSLTENTRAAYPLEHIAQRKEDNCGAEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEIGSTSAIQSTFSTCFGAPFFPRPAGVYAELLMKRIESFGSQVYLVNTGWTGGPHGVGKRFDIPTTRAIVDAIVSGELKDVETVHLDTLNLAVPVAVTGVDSNLLNPINTWGDKALYTEYAQKLAEAFTKNFAKYQVSDAIRNAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_THEVO
Sequence: MKTYLVRYSEIGLKGDRERARMERILADNIINYYKKIGYEARCQLLAGRLLVEAENDIPLSKVFGIKSYSECIRIKFENQEDIVKKVHALYEEKVKGKTFGVRCRRTGTHSFTSIDMEKAIGDALYSISNGVDLKSPEVWIHVDIVGKDALIYDKIYKGPGGLPLGSEGKLISMVSGGIDSPVATWLMMKRGSPCDIFFCSLADPIDTQAFLEIAKKLVERWSPYRDGNVFIADCRDLIRDMVIEKKTNFNNVTFKKVLYRLAERLAEKYRYLGIVTGESLGQVSSQTAENLLSIEHGINFPIYRPLIGLDKDEITAIARDIGTFPEKNVGEFCSLFSAHPVTRSKWEDIEEDVKKIDIEKFIERVTAIKFSEIGKIVINSDLMLNKNLEDAVFIDLRKKDLYEKSHYQGARHLDLEQALAINDTSKKYVFYCSMGLQSAYVASVLRERGIEAYFTTFSKLSKQKGSVDETIGKRV
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_METTP
Sequence: MFTIITGAQFGDEGKGKIVDLLAEKYDIIARFQGGDNAGHTVKVGDKTYKLHLVPSGVLFDKRLLIGPGVVLNPKVLWEELQTLWGMGMKVDLGIDPKTSIIMPYHIEMDALREKARTAKIGTTRRGIGYAYIDKIAREEVQMADITDPEMLKRKLEEIAPAKESAIKEMGGDPSVVRDEAQLRAYLEIGRALKNNLTDVSLEINRALDEDKMVLAEGAQGAFLDVIHGTQKFVTSSFTTAGSACANLGVGPVRVDNVVGVVKAYITRVGEGPMPTELKDEIGDRLREAGGEYGTTTGRPRRCGWFDAVLGRKAVYLNGYTELALTKLDVLTGLRRIKICVAYELDGEILEYPPESTYELARCVPVYEEMEGWSESISEALDYSDLPQNARAYVERIQELMDVDIAAISVGPAREQTIYME
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEB_YERP3
Sequence: MTHPSFIRLRFAFKLSFAIVAALFLGFHLQLETPRWSVLTAAIVSAGPAFAAGGEPFSGAIRHRGWLRIIGTFIGCIGGLVIIVLTIRAPVLTLMLCCLWAGICTWISSLVRVENSYAFGLAGYTALIIIVTTGETPLLTPQFAVERCSEIVLGIVCAVMADLLFSPRSIKQDIDRLVDKVLVDQYRLLQLCIQPAEKSEIDRAWNELVKNTTSLNGMRSYLMMESSRWQRCNRRLQVLHTESLALITQACETYLVMSNHPEVISAELKTMLSEPAQTPAEIHQQMKKLRQFIAASHSEAIPHTISSWVGAATRYLLLSKGIQTNSSINQVEEDILAGDAPVKPISAEGHHAMINGLRTGIATAIGGLFWLWTGWTSGAGCMVMIAVVTSLAMRTPNPRRMALDFLVGVIIALPIGALYFMFIIPSTQQSMLLLCISLGVLAFIIGIEVQKRRLGSLGTLASTINIIVLSNPMIFNVRQFLDSALGQIVGCFVSLIVLLLIRDNAKDRTGRTLLNRFVYSAVSALTTNKTKRGENHLPALYQQLNQLLMMFPADIDKYRLALTLIIAHQRLNRTEIPVNAELSAFHKQIRSTAERVITVNNDQKRRYYFARLLQELDQYQQKLVDYQAADAVIRPVKRLTEMLRKYQSALI
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YBEY_UREPA
Sequence: MHFLITNEVKKIFNDKLYSQRFKQITDLVSTKLNIDKKRFFECHFVDEKTIQEINKNYRNKDYITDVISFAFDDGEIITPLLGEMYICYQKVVDQASQFAHSFERELCFLFTHGLLHLLGYDHIKIEDEKIMFALQDEILNELKITRNINGARND
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL9A1_GADMC
Sequence: AQLVDSMPSASTGSVVVTDDLNYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAAYLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEYDIDAAWQCIEYYAGLAPTLSGQHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAGVPVGLVNVVQGGAETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVEMGDVDSLF
What is the function of this protein?
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro).  Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
What are the official names of this protein?
4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABADH, Aldehyde dehydrogenase family 9 member A1, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PSA6_MOUSE
Sequence: MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITESIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-6, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707).
Protein: GPI2_YEAST
Sequence: MTRSPWKRLLWLKQEYPDNYTDPSFIELRARQKAESNQKSDRKLSEAARAQIRLDFISFYQTILNTSFIYITFTYIYYYGFDPIPPTIFLSFITLIISRTKVDPLLSSFMDVKSSLIITFAMLTLSPVLKSLSKTTASDSIWTLSFWLTLWYIFVISSTKSKDKPSNLSTNILVALVAVLSSRLSTTIDVFCFLLICIQLNIILPTYLSVTNKVVPIISNIIVYSFLNVALGWIYMLLIFFASVFYITVLPKWFIYWKINYHKRDNDLLSTWDARTPILD
What is the function of this protein?
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit, GPI-GlcNAc transferase complex subunit GPI2, GPI-GnT subunit GPI2.
What is the protein family that this protein belongs to?
Belongs to the PIGC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DXR_WIGBR
Sequence: MKKITILGSTGSIGKNTLKIISNNLDKFSVYSLVAYGNNINVLISQCIKYKPNYVCIMNKKKLLDLKQGLLKNKCKTSVLFGSNDICNLSSSKEVDIVISATVGLSGIFFLFSAIKSGKKILLANKEILVSCGHFFMKQVEKYKSIIIPIDSEHNAIFQSLPLDFQKKLGIASINKYGIYKLILTGSGGPFRNVELRDLKKVSPDQACNHPNWKMGKKISIDSATMMNKGFEYIVAKWLFNVCKDQIELIIHHQSIIHSMIRYIDGTVIANMSLPDMQSSISYGLGYPKRIKIKNKYLDFYKNNKLTFESIDYNRYPCLNLAIQASYNGQGATTVLNSANEISVSAFLSKKIYFTDIAIINKKVLDKLDIFEPSSIEEILLLDSKARNLAKKFIKCY
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.