PharMolix/UniProtQA huggingface dataset:
Protein: LST2_CAEBR
Sequence: MQSFRKIWNKPRPDDWMPLARFYYADSALNDIASELDSFDGRRDPDRCNALVTRLRVAQDRVLHIITEMLIHLYPREQDRACRDFRIKFPDEILHDTLPGQLWFGAECLSAGSNIIDHETESDLIRPLAKEVTKQLDILRDLLKNQSLRDPSAYNPVIKENLLKFDKLFAEFEYQYVSAMVPVKSVKEHDSQLDVAVLFSEVLSLALEKDLITQDLIDYCDPSVMIAIPRLGIVWGLLVYSEGALNVDVPAENLSEMFRPFYSLLVKIRNLLRILTPVELTRLETVLCKGETAVPEDSSSKLTMSDFRTNATDEEKAKNNQRVWMCDMPSDSTSSLDSDLRDSASEATSLASSGLTSPSSGSEDNLNRMVDKSDEELDDDVIETASSEENESDSNNENVEMVASSGDSSETESNSKENEEDVDEQATLQALAHETAEQLVAIKKKHEKHSKIIIPMQNEPRTLIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKIILQPSEVIPVYEVVNAQVANNSTEGEETGVEAQETLPLPAFMGVRWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNSISIPEHGYDRKVRVCNLCYVHRLNPFGCNEQSQASENNTGISSVAEQSSAQATSASS
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: DUT_METJA
Sequence: MIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIEIFNSEKDEHIKLDRGVYIVKVADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGRPEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKGR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, MjDUT, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
Protein: DDI2_DANRE
Sequence: MLLTVFCAPRDRSETTFALDVSPELELRDFLALCELESGIPAGEIQIIYAEQPLQDPTRALGNYGLKDGDVLVLRQAERLRAPPQPTVPGLPRIDFSSIAVPGTSSGQNRNRPQQAQRPSTTQPPPPQATTSPGSGVSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLERFTKVLMEQQQDRARRDQERIKLLTADPFDLDAQAKIEEEIRQHNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEDQPMDMLLGLDMLKRHQCSIDLKKNVLLIGTTGTETRFLPEAELPECARLAYGPEGREEPRPDEIADRELAEAIQRSVQDSGKMHDM
What is the function of this protein?
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane.  Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1.  Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2.  Required for cellular survival following replication stress.
What are the official names of this protein?
Protein DDI1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the DDI1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Chromosome.
Protein: TBX32_CAEEL
Sequence: MTSQYSNYSCPLNNIQVNVIGSSRTSDDHFLEQMLTKRKKTNISQDLHYTLLGLNPRDLYQISIKLARIDEKKYKFNGNFNGGDYYPHKNSEIPMEDTEEIVHLDGYQTGARWMKTGVYFPKIGISKEQPDKERCLLLESLHAYVPVLRFTTSSGISLEVTVWSQKFVTTMTSSNRSVKRREKRKLEETTGPSAKKTPEVIEFTQEAVVPEVYNAQQVYQMQNDTMISSDSKFCSPLAFQQDFTEEFGTISQLDAYVNVNVQSCSSSSLSSPAALQQDSTVSSDNDFDDKNSEEFDAVFEYIDQQFSNHDQNPMDQQSKSIDLNQTTWTSQSINNQSYLSTASSPAALNQDSFASEKSSIVRDKKNDENCLDEFDRVFNELDQQFTPTENQLQDLSNCTTWNQEPINNSIQSNQLNNNIAPALEENVEDDNAIFEHFFICN
What are the official names of this protein?
Putative T-box protein 32.
What are the subcellular locations of this protein?
Nucleus.
Protein: ICT1_HUMAN
Sequence: MAATRCLRWGLSRAGVWLLPPPARCPRRALHKQKDGTEFKSIYSLDKLYPESQGSDTAWRVPNGAKQADSDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLATAEWIAEPVRQKIAITHKNKINRLGELILTSESSRYQFRNLADCLQKIRDMITEASQTPKEPTKEDVKLHRIRIENMNRERLRQKRIHSAVKTSRRVDMD
What is the function of this protein?
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit.  Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation.  May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
What are the official names of this protein?
Peptidyl-tRNA hydrolase ICT1, mitochondrial, 39S ribosomal protein L58, mitochondrial, MRP-L58, Digestion substraction 1, DS-1, Immature colon carcinoma transcript 1 protein, Mitochondrial large ribosomal subunit protein mL62.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
Protein: TRHBN_MYCTO
Sequence: MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSAFFSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADALTAAGVPSETITEILGVIAPLAVDVTSGESTTAPV
What is the function of this protein?
Binds oxygen cooperatively with very high affinity.
What are the official names of this protein?
Group 1 truncated hemoglobin GlbN, Truncated hemoglobin, trHbN, Hemoglobin-like protein HbN.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group I subfamily.
Protein: Y4802_PSEPK
Sequence: MSEPDVKSHKIEFPCDDYPIKVIGDTVVGFKDMVIEVLSKHAKVDLSTLAERQSKEGKYTTVQLHIVAESENQLHDINSALRATGIVKMVL
What are the official names of this protein?
UPF0250 protein PP_4802.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: H2A6_ARATH
Sequence: MAGRGKTLGSGGAKKATSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELSKLLGDVTIANGGVMPNIHNLLLPKKAGASKPQED
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Required for the T-DNA integration step of plant transformation by Agrobacterium.  May play an important role in illegitimate recombination.
What are the official names of this protein?
Histone H2A.6, HTA1, Protein RESISTANT TO AGROBACTERIUM TRANSFORMATION 5.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: EFG_VESOH
Sequence: MARTTPLDRYRNVGIMAHIDAGKTTTTERILLYTGRTHRIGEVHDGSATMDWMEQEQERGITITSAATTCFWKGMDGQFEDHRVNIIDTPGHVDFTIEVERSLKVLDSACAVFCAVGGVEPQSETVWRQANKYNVPRIGFVNKMDRSGADFLRVCKQIKTRLGGNPVPMQIAIGAEESFEGVIDLISMKAIFWNEVDQGATYETRDIPIELQGLAKEQYEFMVESAAEANDELMEKYLEESKLSNHDIKKGIRLRAIKSEIIPMFCGSAFKNKGVQAVLDAMIMYMPSPLDVDAITGISDDKDETVVPRKADDNEPFAALAFKIATDPFVGNLTFFRVYSGVLEAGDFVYNSSKGKKERIGRMVQMHSNERDEIKEVRAGDIAAAIGLKDVTTGDTLCDMKEKIILERMEFPEPVIALAVEPKTKADQEKMGIALGKLAAEDPSFRVSTDEESGQTIIAGMGELHLDIIVDRMVREFDVECNVGAPQVSYREAITTMVEHQHKFVKQSGGRGQYGHVYLRIEPQEPGTGYEFVDEIKGGVIPKEYMPAVNKGVQEQMENGVLAGFPLVDIKVTVYDGSYHDVDSNEIAFKIAASKCLSEGVKMANPQLLEPMMAVEVLTPEDYMGDVMGDINRRRGIVSAMEDMPAGKQVKAEVPLAEMFGYSNDLRSITQGRANYSMEFAKYTAAPKNVADEIIEKLNK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_RICRS
Sequence: MKKIILVAGGTGGHFFPAVALGEELIKRGYEVHFITDLRCKQYIKQDMKVIFHILDLKRSGNIFLFLPRLSIAVLKAIKLLYNMKPSVTVGFGGYPVIAPMFAAIFLRVPIIIHEQNSYLGKVNKFFASFAKKIAISYEKIKNLPEFAKSKIVVTGGVVRENIRELKVIEMSSRGLTTGSKKSLIKALDSVVKPRHDKLFTIFIFGGSQGAKLFSELIPASIQILMQKQPSLELNIIQQAALDDQVKIKDIYSKLNITYEVAEFFDNMALQYKEADLVISRAGASTIEELTYIGLPAIFIPLPSAADNHQYYNAQLLADEKTGWCLEQNNISAGKLADKILDLISNPKILEDASQNLLKRRKEGHKLLSNLIEEVI
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LOLA_WOLSU
Sequence: MRIALLWVAFGALALAAFESIGSFRSEFVQTIRSEDGKIIEYRGRVYAKSPYYGLWKYEKPMEKEIYIVDKQVVIYEPALEQATVSSLQNSIDFMALLRQSKRNSEGIYEATVFEQKYQILADEKGEPQKVFFIDKLHNEVQIIFKNAEINPVLEKEMFLFMPSGEIDLIRQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GEFW_DICDI
Sequence: MAERVKILKPGLTNRSRSASIDMIVMDEIAKNNPIYTNDNSNNNNNDETSSNISGSNSIQNLSLNNLNNLSGGGGGSNSNSVNNTISERNPDSPRFRSNTGNLQTMMMVSNGNIIGSIQSPSPPISPRAQMTAPNLSKFLDQHTPPPSPKPEHLSGHLRIQQQHHSGIYRNLSFSSVNSSTSFGDFKRSTNLFQPPQSQSQQQQQLQLQQQQQQSMPNLSLGNNINSNNNNNNGSENNDISMEIKDNTSGIDTSVKSFSPRKKRKKENKIIRRIRRWMTWVISSNIWLTIMIISIIFVLFIDDIIGASGSPSSNAIDYSIMAVKCSIIGFFSIDIILNLFCFQQEYFPGTIVFWLDLISLISIVTDIHHFQNYYANLVLSITVNTRIIRICGSFIRISLISTLYNRFLRKQTLPSEGLEVEASKLGDKLIRLTTNKIVLLALAVLFATQLLVYESDTPTQYIQSTISSFEYLSSTYGLQSPEFTGVFNNYQLNNEKLLFTQISNQKIFNLPDKINSLQERSILKYNYLNSIIWIDNSYYIKYSCILHLCLTVFVILVLITINLLIVNDAHWLVINPLENVLTIVKLLSKQNSMIKQGGGGSGIVGGFSNNTINSNSNLNSNSNLNSNSNSNLVRNRVESIGNKSDTADTTSSSGIDNEEPDEADFLLGMLNEIDDSLQAAKEKVEEESIQNSILKKDIEDLYVEKYILQVHLRSIVRKINFHDPIGHYLKNRQLLLMQSNATFNTLEQDSEDDIRFKLNDDGLPDLNVIQYATIDKLIEKLTMAEAHDLKFANVFLLTYRKFLSPVELMERLTIRFCVTPTMELPEKLLASKEQVEQWRKTKQEQIRTSVFNTIKLWIGIYNWDFYENPDLYELFNNLVNKIMPFCKMEKHATYIDSIHKRKMATYIQDPPYIPIEPLTQEEIAETMVLEDRLLFNFDISDIAIQITLMEFDLFKNIKSKEFLNLAWTHKTEKTRLSPNIVRFIEHFNSVSFWLQTCIVKSGKIKERVAVLKKVIALADVFVQLNNYYGAMEVLSSLESSAVSRLHKTWEQVPQSSIQSLQSLQKLLSPQENFKNYRERISKCGSCCIPYIGLYLSDLTFIHEGNPDYYQQSQLINFSKLREVAITINTIKQFQNIFYYYEKNQNIRSQMNFKSPGADIIWKMSLSCEQRNK
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP.
What are the official names of this protein?
Ras guanine nucleotide exchange factor W, RasGEF domain-containing protein W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL28_WOLTR
Sequence: MSRVCELTNRKKSFGNKVSHSNRKAKRIFLLNLHNVTLISNILNKKFKFRVAIRTLRTIDYKGNLDAFLLNTRTVKLSKKAQKIKRKLKKVLAKQEVELGISDA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: BR2B_RANDY
Sequence: GLFDVVKGVLKGAGKNVAGSLLEQLKCKLSGGC
What is the function of this protein?
Antimicrobial peptide.  Active against the Gram-positive bacterium S. aureus (MIC=30 uM) and the Gram-negative bacterium E. coli (MIC=30 uM).
What are the official names of this protein?
Brevinin-2DYb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: YHEH_BACSU
Sequence: MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQAVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLLVFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHISFTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA
What is the function of this protein?
Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone.  Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IF2P_METBU
Sequence: MVVKDNLRTPIVCVMGHVDHGKTSLLDMIRGSAVVSGEAGAITQHIGATEVPISAIVEKCGNPGLLDKFMVPGLLFIDTPGHHAFTTLRSRGGALADLAVVIVDINEGFKPQTIESLNILQQHKTPFVVVANKIDKIHGWNPQKGAPFMTSYNKQSEHVRGSLDTKFYEVVGELYNHGFSSDRYDRVNDFQHNIGVIPISAITGEGIPDLLMVLLGLAQRFLESNLHYNAEGPGVGTVLEVKEERGLGTTLDLILYDGVLKKGDTIVVGCLGEPIQTKVRAVLKPRALSEINVEDKFKQVSKVTAAVGVKISAPHLDGALSGGSVRVATAETLDAVVEEVRNEIEDVQIDTDQSGITIKADTIGSLEALVNELKKEDIPIRKANVGDISNRDIMEAFAIEDPFHSVIVGFNVNILPDAKEKVRSTGVKVFMNDVIYRLIDDYRDWVKEQRAISEKAVSETIVKPAMFTIMPDCVFRQSKPAVVGVRVIGGTIKTKVDVATGDGTVVGIVKGLQSRGENVSVATIGMEVAMSIEGPTVGRQINEGDILHANIPERHVKILEQELYDSLSADELEALDSFLDIKRRDNPFWAK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: MCR_SAISC
Sequence: METKGYHSLPEGLDMERRWGQVSQAVEHSSLGSTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYYEQQNQQRSMSPAKIYQNVEQLVKFYKENGHRPSTLSCVNRPLRSFMSDSVSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTPRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTSRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGTCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARRSKKLGKLKGIHEEQPQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSAISRALTPSPAMVLENIEPEVVYAGYDNSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFIRLQLTFEEYTIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVNDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
What is the function of this protein?
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol.  Binds to mineralocorticoid response elements (MRE) and transactivates target genes.  The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
What are the official names of this protein?
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding.
Protein: RL23_SYNJA
Sequence: MTESKRILADVLLRPVITEKATALMEQRKYVFEVMPTATKPLIRAAVEEMFGVRVTAVNTLKLPRKQRRVGRSVGYRSRPKRAIVTLAEGDSITLFPDT
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PRIB_ECO55
Sequence: MTNRLVLSGTVCRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: URM1_YEAS1
Sequence: MVNVKVEFLGGLDAIFGKQRVHKIKMDKEDPVTVGDLIDHIVSTMINNPNDVSIFIEDDSIRPGIITLINDTDWELEGEKDYILEDGDIISFTSTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GPI7_ASHGO
Sequence: MRFKEVGLLFCQLLAVLIFAAGFFPQKKVLKGDAQFQYMAETQRALEPAFDKLVLVVIDALRADFLFQQNVSHFDFVHELLNRGEAWGFTAYSNPPTVTLPRLKGITTGSAPNFLDAILNVAEDDSSSNLKDQDSWISQFAKHGKKIHFFGDDTWLKLFPEEFFQKHDGTNSFFVSDFEEVDTNVTRHLPHELQHKDWDVLILHYLGLDHIGHKGGAASQFMPPKHREMDAVIRQIYDQVDNRTLLCVMGDHGMNDLGNHGGSSAGETSAGMVFISKMLSSYPRPAAQDGVSSPVTAAEDYQFFTRIQQVDFVPTIASLFNIPIPKNSLGVFVREFSSLLGQHATTKIIENYHQLMQLAAKKTAARGNDDIDSMLAEMKDVQATLARTATNYNYAMLFLGVGMLSIVTAATAYCYISSARLNEASVLMIAVTALLGSSVFGSSFVEEEHQIWWWIIIAVVGYSWATRPSCTPSHLVFLVCARLLRGWNNSGQKFMYDFTVAELLKSHPSIKWLLVCATLAVVALDGFTERPLLSIFNLLAGLLCFVYKTCWANVNGEVSPTYAQTLVTKACSLLFAGGTPWDDKQLLVPLARLFFKVTAAIVCMRIAYNVVFAKRKFLSELFPLFTIVLIMQTASQNIPLFLVFTIMRSSLRNILRVGYPQQRCEMFFVLSLILQNLSFFQFGGTNSIATIDLTNSYNGISENYNIYVVGLLMCIGNMAPAIYWSLAAVVDHQLYSKKSYAQQKLSSMFFYSVNSLLLLVACICMRYHLFIWSVFSPKLCYLLGWNILIHFLTETVLEPFLLMVAG
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the GPI second mannose (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 2, Glycosylphosphatidylinositol-anchor biosynthesis protein 7.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YOAL_ECOLI
Sequence: MDRHRRHFSIRPFNACLSGTLCRTFRLHFVVTPALFLASNSYSLSRSLSWNS
What is the function of this protein?
May serve a regulatory role in expression of downstream gene yoaE; in a yoaL-yoaE-lacZ fusion mutation of the start codon to a stop codon in yoaL decreases expression of beta-galactosidase, suggesting translation of the 2 genes is coupled.
What are the official names of this protein?
Protein YoaL.
Protein: KUP_NITEC
Sequence: MALDSESSASNRQGSRNEQDTNPRLTAALCLTALGVVYGDIATSPLYAFREALHNIAPDSRTPESILGILSLIFWALIILVSIKYLLIIMRADNHGEGGILALLALLRPWRGSPQHQRNVLIVLGLFGAALLYGDGMITPAISVLSAMEGLEVAAPQLTSYIIPATTVILVLLFMVQKRGTARIGRVFGPIMLVWFVVIALLGLNGIIHHPQVLVAVNPYYGINFFTDNGWSAFRVLGGVFLALTGAEALYADMGHVGRAPIRLMWFALVLPALLLNYFGQGALLLLDPHEAQPFFHLAPPSFLYSLVGLATLATIIASQAIISGVFSLTRQAIQLGQSPRLTLVQTSSEEIGQVYVPAANWFMMIAAVWLVLHFRSSDNLAGAFGIAVSGTMVITTILAFFVMRERWHWNILTAVAVTVGFLIIDLAFFSSNLLKITDGGWFPLAIAVFIFTLMITWQQGRQLLIQRIHKETESFQDFLQRIVTDPPVRVSGTAVFLTIHQHDTPPALLYQLIHNKALHEQVVLVTVITEEVPRVPAAERLEVMELSSGFHRIIVHYGFMQSPNVPVALRACETLGLKIDLDTTTYYLSRASLIPTDERPGMALWRDRLFAFMSRNSAWPTAFYHLPPEHVIELGIQVEL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KDGD_PSE14
Sequence: MNPQELKSILSSGLLSFPVTDFNAQGDFHRAGYIKRLEWLAPYGASALFAAGGTGEFFSLAASEYSEIIKTAVDTCATSVPILAGVGGPTRQAIEYAQEAERLGAKGLLLLPHYLTEASQDGVAAHVEAVCKAVKIGVVVYNRNVCRLTPTLLEQLAERCPNLIGYKDGLGDIELMVSIRRRLGDRFSYLGGLPTAEVYAAAYKALGVPVYSSAVFNFVPKLAMDFYHAIARDDHEAVGKYIDDFFLPYLEIRNRKAGYAVSIVKAGAKIAGYDAGPVRAPLTDLTPDECDMLAALMDKQGKQ
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: PEA15_HUMAN
Sequence: MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA
What is the function of this protein?
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade.  Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity).  Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis.  Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
What are the official names of this protein?
Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED.
Protein: Y1056_AERPE
Sequence: MVGGVRIARARGPPIEPEELDDADGEALVRIARRAVEEWVEHGRRLDVEAGGKLGRPGAAFVTLERRSGDGWELRGCIGVVRPVLPLVEAVVTAAVDAASSDPRFEPLSREELDRVRVEVTVLGSMEPLPKKPHERPALVEVGLHGLYVEKPPYAGLLLPQVAVDEGWDPILFLTWACIKAGLPGTCWLREDVEIYRFRAAVWRETEPRGPVVRRDLAREAAAKGVNARVS
What are the official names of this protein?
Protein APE_1056.1.
Protein: FLHC_CUPNH
Sequence: MDVHDIAGTAVAGSPAPVPRARPPRPGKSMLQDVEQIRLAIEMIGLGARLQVLESEVSLPRVRLIRLYKELCGVSPPKGMLPFSTDWFVSWRPNAHASMLLGAYRFMTSRGSLDGIRAVLSSYRMYREQLCATGEASQLSFTRAWTLVRFYERGMLRLARCRDCRGEYVVQADDARHRYVCGLCLPPARAGKGRKPAPAALAG
What is the function of this protein?
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhC.
What is the protein family that this protein belongs to?
Belongs to the FlhC family.
What are the subcellular locations of this protein?
Cytoplasm.