PharMolix/UniProtQA huggingface dataset:
Protein: FDHD_SACS2
Sequence: MGVRVKRFDLVRVKDSEAYKDSDFVAVEEPLNIRTCFEKCEDFAIIMRTPGDDKELSLGFLYSEGVINSIHDVEDIKQVENNVIEVKLNKPIGIRIRELIVNSSCGVCGRAFLYTLNILKSDLKVKREVIFSFPEKLREKQSVFNISGGLHATALFNPQGELLFIYEDVGRHNAVDKVVGRLLLEDKIPASNYIMQVSGRLGYEIVSKGIKAGIPIICGISAPTSLAIEIAEEAGLTLIGFLRGKSLNIYTHSERIY
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1268_SULIK
Sequence: MSKKIINEVIDILEDKKYTYTMIEYPEHNRKSVDIVLNSKEPTLIRVSEDKVTKEEISDLKKIAVSTLTASLVVTNEEEEDIVSVKADNVFAVSPEGFKKVINGEKIFLYRTRGGIFIKIRNYILKHKREEMGYSIGDVAKFLGVSRKAIYDYEKGDSDVSLEVAEKLIDLFGDDIIGDVIWDSIKGKKEVIEEDITEFSPESFKSKLIYKLKENGLNILSLKLTAADLIVKDNENNRYLVTIENKDYNKSMKKFYEAKKLASYTKSELLIIIRTSKMLKECEDLGYKTYEENDIHSLIDEIKGSNGRQS
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein M164_1268.
Protein: RTCA_ECOLI
Sequence: MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP4_METST
Sequence: MSRRKRPNWINTIALERMQILFEQAEKEFSKHPERSDRYVKLTRNISTKYNIPLPNYWRGRFCKNCNKFLKPGSNLRVRLSNNTISRKCLECGDLKKVPYTKKN
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK19_HUMAN
Sequence: MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
What are the official names of this protein?
Cyclin-dependent kinase 19, CDC2-related protein kinase 6, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19, Cyclin-dependent kinase 11, Death-preventing kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein: HFQ_VIBC1
Sequence: MAKGQSLQDPFLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARPVSHHSGDRPQGDRPQEKSED
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: TDCD_SALTD
Sequence: MNEFPVVLVINCGSSSIKFSVLDVATCDVLMAGIADGMNTENAFLSINGDKPINLAHSNYEDALKAIAFELEKRDLTDSVALIGHRIAHGGELFTQSVIITDEIIDNIRRVSPLAPLHNYANLSGIDAARHLFPAVRQVAVFDTSFHQTLAPEAYLYGLPWEYFSSLGVRRYGFHGTSHRYVSRRAYELLDLDEKDSGLIVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFGAMAWIAKETGQTLSDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERARLAIKTFVHRIARHIAGHAASLHRLDGIIFTGGIGENSVLIRQLVIEHLGVLGLTLDVEMNKQPNSHGERIISANPSQVICAVIPTNEEKMIALDAIHLGNVKAPVEFA
What is the function of this protein?
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP.
What are the official names of this protein?
Propionate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family. TdcD subfamily.
Protein: RF1_LEGPC
Sequence: MKKSLELKLQQMLERYEEVGRLLSEASIIADQNQFKSLSKEYAQLEPVSQCYESYLEAKNNLDSLNELLESDDKDLATMAEEEIDIVKKQIEELDEQLQWHLIPKDPDDERNIYLEVRAGTGGDEAAIFAGDLFRMYSRYAESQGWQIELISASHGEHGGYKEIIAKISGQAVYSQLKFESGAHRVQRVPETESQGRVHTSACTVAIMPEVDEINDIQINPDDLRIDTYRSSGAGGQHVNKTDSAIRITHIPTGVVVECQDERSQHKNRAKAMSLLKTRLLDAEVSKQKQEQAQTRKSLVGTGDRSERIRTYNFPQGRLTDHRINLTIYQLSDIMEGNLSLVIDPLKREYHAELLADLGRHD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_LACDB
Sequence: MAKDIKFSEDARRSLLNGVNKLANTVKTTLGPKGRNVVLEQSYGAPTITNDGVTIAKAIELEDHYENIGAKLVAEAASKTNDIAGDGTTTATVLTQAIVQEGMKNVVAGANPVGIRRGIEKATKAAVDQLHKNSHKVSSRDQIAQVASISSASKEIGDLIAEAMEKVGKDGVITIEDSRGIETELSVVEGMQFDRGYLSQYMVTDNDKMEADLENPYILITDKKISNIQDILPMLQEIVQQGRSLLIIADDVTGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKEQLADIAALTGGTVISEDLGLELKDTQLSQLGQARRVTITKDSTTIVDGSGAKEAIQERVDTIRKQIEDTSSDFDKKKLQERLAKLTGGVAVIHVGAATETELKERRYRVEDALNATRAAVDEGYVAGGGTALVNVEEAVKATKGDTDDEQTGINIVARALTAPVRQIAENAGQEGSVVVDHLRKVDPEVGYNAAEDKYVNMIDEGIIDPTQVTRSALQNAASIAGLLLTTEAVVAEIPEDKPEAAPAQPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP1A1_PLEPL
Sequence: MMLMMLPFIGSVSVSESLVAMTTMCLVYLILKFFQTEIPEGLRRLPGPKPLPIIGNVLGLGSKPYLSLTAMSKRYGHVFQIQIGMRPVVVLSGTGTVRQALIKQGDEFAGRPDLYSFRFINAGKSLAFSTDQAGVWRARRKLAYSALRSFSTLEGTTPEYSCVLEEHICKEGEYLIKQLNTVMKADGSFDPFRHIVVSVANVICGMCFGRRYDHDDQELVSLVTLSDEFGRVVGSGNPADFIPILQYLPSAEMKNFLRINEHFTEFVQKIVTEHYTTFNKDNIRDITDSLIDHCEDRKLDENSNVQMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIEDKVGLDRMPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQINHDPELWKDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAIIIQKLHFLPIPGEKLDMTPEYGLTMKHKRCHLKATMRARNEH
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 1A1, CYPIA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CPSB_STRPN
Sequence: MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYTQVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVTQKYGEAKAQELFIDNPRKIVMDQLI
What is the function of this protein?
Dephosphorylates CpsD.  Involved in the regulation of capsular polysaccharide biosynthesis (By similarity).
What are the official names of this protein?
Tyrosine-protein phosphatase CpsB.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.
Protein: HIS4_CROS8
Sequence: MIIPALDLIDGTVVRLHQGDYGQQRDYGRDPLPRLQDYEAQGAQLLHLVDLTGAKDPAKRQIALIQKLVAGVNVPVQVGGGVRSEDDVAALLDAGVARVVVGSTAVKAPQDVQRWFQRFGADALVLALDVRIDDAGNKQVAVSGWQENSGVTLETLVESYLPAGLKHVLCTDISRDGTLSGSNVALYEEVCARYPQVAFQSSGGIGELSDIRALRGSGVGGVIVGRALLEGKFNVTEAIQCWQNG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1427_METMP
Sequence: MFVPEEIIETIKMIEYQNLDIRTTTLGINLKDCADKDLDLLKENIYDKITSLGGNLVETANKVSQKYGIPIVNKRISVTPIGLIMGSTVKGLSDEEAVDACVEVGITLDKIAKEVGVDFIGGYSALVQKRATYEEKMLIRSIPKLMTKTDKVCASVNVATTKAGINMYAVKKMGEIVKETSEITKDAIGCAKIVVFCNAPEDNPFMAGAFHGPGEGDAVINAGVSGPGVVRAVVEQLKGKDIGTVSDEIKKTAFKITRMGELVGKEVANELGVNFGIVDLSLAPTPAIGDSIANILEAVGLERCGTHGTTAALAMLNDAVKKGGAMASSNVGGLSGAFIPVSEDAGMIEAVEVGALRLEKLEAMTCVCSVGLDMIAVPGKTPASTLSAIMADEMAIGMINKKTTAVRIIPVPGKDVGDYVEYGGLLGTAPIMPVSEFSSEELIERGGRIPAPIQSLTN
What are the official names of this protein?
UPF0210 protein MMP1427.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: ARY2_MOUSE
Sequence: MDIEAYFERIGYQSTRSKLDLKTLTEILQHQIRAIPFENLNIHCGESMELSLEAIFDQIVRKKRGGWCLQVNHLLYWALTKLGFETTMLGGYVFNTPANKYSSGMIHLLVQVTISGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWYLDQIRREQYVPNQEFINSDLLEKNKYRKIYSFTLEPRTIEDFESMNTYLQTSPASVFTSKSFCSLQTPEGVHCLVGSTLTYRRFSYKDNVDLVEFKSLTEEEIEDVLRTIFGVSLERKLVPKHGDRFFTI
What is the function of this protein?
Participates in the detoxification of a plethora of hydrazine and arylamine drugs.  2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2.  Less activity with anisidine and barely detectable with SMZ.
What are the official names of this protein?
Arylamine N-acetyltransferase 2, Arylamide acetylase 2, N-acetyltransferase type 2, NAT-2.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_CALBD
Sequence: MKIRPIGDRILIKFKEREEVTKSGIVLPDTVKEKPQIAEVIEVGPGGIVDGEKVEMVVKKGDKVIVSKYAGTEIKIDGEEYTIIRQDDVLAIIED
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_MARN8
Sequence: MQDSPANVVQPDWLDDIQWTEDGLVPAIAQDADNGDILMMAWMNRESLRLTVEEGQAVYWSRSRGKLWRKGESSGHQQVLRDIRLDCDADVVLLKVEQKGGIACHTGRRSCFYRTLKDGQWVSADPVIKDPNTIYGSN
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_HYDCU
Sequence: MDKLVIEGPCQLEGSVQISGAKNAALPILMGCLLSETPVVLSNVPHLKDVTTTIQLLATMGVEVMFDEELNIEIDASNITTKEAPYELVKTMRASILTMGPLLARFGEAKVSLPGGCAIGSRPVNIHIEGMQKMGAEIKVEQGYIIATADRLVGADITMEPVTVTGTENLLMAAVLAEGRTTLRNAAKEPEVSDLAHFLNKMGAKITGIDTDTLVIEGVEKLTGVSYRVIPDRIEAGTYLAAAALTKSCVTVKDVVPEHLTAVLDKFTEAGALVTTTDNTITLDMRNRSLKPVNIVTDPYPAFPTDMQAQFVVMNCLAEGEANVEETIFENRFMHVSELVRMGADIHVEGNVAHTKGVDHLIGAPVMATDLRASASLILAGLVAKGETVVSRIYHIDRGYELIEEKFHKLGAHIYRAN
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCN3A_MOUSE
Sequence: MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDIDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNHRPEGDRFPKSESEDSVKRRSFLFSLDGNPLSGDKKLCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRPGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDSWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKIRECFRKAFFRKPKVIEIHEGNKIDSCMSNNTGVVEISKELNYLKDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISNTYDKETIKGRIVLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEV
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:29142310).  May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (PubMed:29142310).  In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (PubMed:25172946).
What are the official names of this protein?
Sodium channel protein type 3 subunit alpha, Sodium channel protein brain III subunit alpha, Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subtype III, Voltage-gated sodium channel subunit alpha Nav1.3.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basal cell membrane. Note=In enterochromaffin cells, localized highly asymmetrically, almost exclusively at the basal side.
Protein: SPED_CLOBB
Sequence: MMLGLENKLKLYGFNNLTKTLSFNIYDVCYAKSEREQKDYIAYIDEQYNSERLTNILCDVTKMIGAHVLNISKQDYDPQGASVTILISEETLAVKEIDKSCNLGQIDILNTRDTIVGHLDKSHVTVHTYPEYHPDNSIATFRVDIDVSTCGEVSPLNALNYLIGSFDSDIITIDYRVRGFTRDVDGKKLFIDHKITSIQDYIDENTLKRYDAMDINVYQSNIFHTKMLIKEIELQNYLFNRDVYEIKPKQRLEIENNLRKEMIEIFSGTNIY
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: FIS1A_ARATH
Sequence: MDAKIGQFFDSVGTFFSGSDKIPWCDGDVIAGCEREVREATDSGTEDLKKECLMRLSWALVHSRQTEDVQRGIAMLEASLESSAPPLEDREKLYLLAVGYYRSGNYSRSRQLVDRCIEMQADWRQALVLKKTIEDKITKDGVIGIGITATAFGAVGLIAGGIVAAMSRKK
What is the function of this protein?
Component of the peroxisomal and mitochondrial division machineries.  Plays a role in promoting the fission of mitochondria and peroxisomes.
What are the official names of this protein?
Mitochondrial fission 1 protein A, FIS1 homolog A, AtFIS1a, Protein BIGYIN 1.
What is the protein family that this protein belongs to?
Belongs to the FIS1 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Protein: NUOH_XANAC
Sequence: MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKLLFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIVAGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKGGWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TMM9B_HUMAN
Sequence: MATLWGGLLRLGSLLSLSCLALSVLLLAQLSDAAKNFEDVRCKCICPPYKENSGHIYNKNISQKDCDCLHVVEPMPVRGPDVEAYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFANAHDVLARSRSRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVLS
What is the function of this protein?
Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands.  Has a role in TNF activation of both the NF-kappaB and MAPK pathways.
What are the official names of this protein?
Transmembrane protein 9B.
What is the protein family that this protein belongs to?
Belongs to the TMEM9 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass membrane protein. Early endosome membrane; Single-pass membrane protein.
Protein: CYDE_METM6
Sequence: MDDSKHILITKILKNEVTEALGCTEVGLIGYAVSLCNISDPFSIDKLELTLNNGSFKNAYAVGVPNTGKYGILPAVVGGLLGNSKNKLLIFNDITYSQELEDFIKEKLEIKVIDGPLFCNIKIKDNSGNYFESLIKDNHLNVVIPKIEKEKIDVEITTSEKGEYKNLELIDFLDYLDEIPEKIGKLVEKTVQTNKNLIKGDFLNYGTDILSIIVNKTTSACNTRMTGENMPAMSVAKSGNMGIMATLPIISYDSSTENNSEKLIKSVLLSMLVTIYSTYNSSYLSSMCGCVSKGGMGAVIGLCYYKNGKNLKKLDSSARTFTANLPGIICDGGKVGCALKLASGCFAAYSSLFVDISYENGIVGKDFKECVENISKISKAMGDLDCDIVEIMSKKM
What is the function of this protein?
Catalyzes the cleavage of L-cysteine to form 2-aminoprop-2-enoate and sulfide.  The former then spontaneously hydrolyzes to pyruvate and NH(3).  May be responsible for the production of sulfide required for the biosynthesis of iron-sulfur centers in this archaea.
What are the official names of this protein?
L-cysteine desulfidase, L-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the L-cysteine desulfidase family.
Protein: LOLA_YERPS
Sequence: MKRLLVACCFLSGLISASALADASTDLQNRLSKVNSFHASFSQAVTSSDGAVVQEGEGELWVKRPNLFNWHMTSPDESVLISDGETLWFYNPFVEQATATWLKNATGNTPFMLITRNNPDDWKQYNVKQKGDDFELTPKSASGNLKQFAISVTPSGTIKSFTAVEQDGQRSAYTLKSQQSSVVDASKFTFTPPKGVTLDDQR
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EDEM2_HUMAN
Sequence: MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
What is the function of this protein?
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655).  May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).  Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
Protein: YCF3_CHLSC
Sequence: MPRSRINGNFIDKTFSIVANILLRIIPTTSGEKEAFTYYRDGMSAQSDGNYAEALQNYYEATRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIRQGDSEIAEAWSDQAAEYWKQAIALTPGNYIEAHNWLKITRRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.