PharMolix/UniProtQA huggingface dataset:
Protein: HV169_HUMAN
Sequence: MDWTWRFLFVVAAATGVQSQVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-69, Ig heavy chain V-I region EU, Ig heavy chain V-I region SIE, Ig heavy chain V-I region WOL.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: GAL1_ECO81
Sequence: MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDTPIIAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAPR_LISIN
Sequence: MKKYSKKDRQMKLQVAIEENPFITDEQLAEKFGVIVQTIRLDRVALSIPELRERIKHVASVNYADAVKSLPIDEVIGEIIDIQLSKSAISIFDVRSEHVFKRNKIARGHHLFAQANSLATAVIPNELALTTQATVRFVRSVYEGERIIAKAKVRPATDNRAITIVDVKSYVGDEIVLKGKFEMYHATQK
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: RDGC_SHEB8
Sequence: MWFKNLTLYRFNKPFAVETEALETALADFTFSPCSSQDVSKFGFSNALGKKGCSLVHSADNRHLICVTKEEKILPGQVIKEALEEKVALIEDEENRKMAKKEKDALKDEIITSLLPRAFSRRSQTHALILPELEMILVDSSSATKAEELLALLRKALGSLPVIPLSFKAPVESNLTEWLKLGSAPLPFEMQDEAELKSEADEGGIVRFKQQDLKEDEVLAHLATGKQVHKLALHFGQSIALLLQSDASVKRLKFSEEFRAGNDEVGTDDPMARLDADFALMGSELVALMHALVAALGGLEDAQV
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SUB1_TRIRU
Sequence: MGVFRFISISLAAVSAANAAQILSMPHAQTVPNSYIVMMKDDTSDDDFKHHQSWLQSTHTHNITRRATIQNAGMRHKYNFNKMKGYSGIFDDETIKDIAKDPKVMFVEPDTIVSVHGKVEQSNVPSWGLARISNPQPGADSYTYDSSAGEGITVYSVDTGVDVNHEDFEGRAIWGSNQVNDGDDRDGSGHGTHTSGTMVGKMYGIAKKAKLVAVKVLGNDGSGPTSGIVAGINWSVEHARQNGGTKKAVMNMSLGGSSSSALNRAAAQAVEQGMFLSVAAGNDNQDAQSSSPASEPSVCTVGSSAEDDSRSSFSNWGPAIDIFAPGSNIVSARPGGGSQSMSGTSMAAPHVAGLAAYLMALEGISGGAVCDRLKELGTSSITDAGPGTPTNVLINNGGAKGGQPNPNPAPAPSPSQPSEPQQPTPSQPGQPGEPFPGEPFPGEPFPGQPFPGESAPAPAPAPMPPTPQHPHTPYPGGDNFDFDSFWKKYFGGEHWRKMFSSFWN
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGB_META3
Sequence: MDNALKAEVLIESLPYICKFQDQKIVIKYGGHAMVDEEAKSWIAKDVVLLRFVGLNPVIIHGGGPEINKAMEKMGKEPEFIHGLRVTDEETLDIVKMVLIGKINGDIVSKLGKYGGKAVGLSGKSGHLISARKKIQYIIKEDEKIEVDLGRVGEVDSINTELIDILLEKKYIPVISPIGIDSQANTYNLNADIAAGDIAGAINAKKLIMITDVDGVMDDINDPSTIYKKLTISQVGEMIDKGIISGGMIPKIEACVNALRKGVDSVHIINGKIPHSVLLEVFTEEGIGTMITRD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_MESHJ
Sequence: MVRIRLQRMGSKFNPFYKIVVADARAPRDGRFIEALGYYNPQQKFAKVNLEKTYRWLHIGAQVTQTVRNIFSKKGVFKNFLEQKSSRA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: COX2_GAZSP
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYVISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSARPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HPCH_SALCH
Sequence: MKNAFKDTLKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEPLAKRYLELGALFVAVGVDTTLLARGAEALAARFGVEKNLSGASGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: DER_RICPU
Sequence: MTKQIITLVGRPNVGKSTLFNRLSIRKKAIVHDLPGVTRDRKYTDGKIGSFEFLLIDTPGLDENPNSMGERLIEQTTKAILEADLICFMVDGRSGILPDDKLLSSFVRKYNKPAILVVNKCEKAFDFDKEYYKLGFDSMIAISAEHGTGLIDLYDEIIAKLPEEESIETNIADPIKGDCLQIVVSGRPNAGKSTFINALINDERLLTGPEAGITRESIEIDWQYKNNHIKLIDTAGLRKKSTITESLEKLSASDTINSIKFANTVILMIDALAPLKQQDLNIASHVVNEGRSIVIVVNKWDLVKESEKEAFQEEFYYQINTHLPQVKGIPVLFISAINKQNIEQVLDACLKIYKIWNKKITTSKLNEWLNFTTKAHLLPLQKGGRRVRVKYMTQTKTRPPTFKLFSNNPEKITDSYTRYLVNNMREAFDMPGIPIRFIYVKTKNPYV
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SYY_PARMW
Sequence: MPESTPSLPDWLSRGMADLFPAGDPTDADQALAARLAQAEKEGRPLRVKLGIDPTGSNIHLGHSILFRKLRAFQDAGHTAVLIIGDFTARIGDPTGKCATRVQLSKEDVAANASTYLRQLGQDQPKETALLDFETPGRLEVRYNSEWLEGMDLPAVIGLLGTGTVGQMLAKDDFSKRYGSGTPIALHEFLYPLLQGYDSVAVNADVELGGTDQKFNVAMGRDLQRHFNKGTQFGLLLPILVGLDGVQKMSKSLGNVVGLEEDPLSMYSKLEKVGDGAINDYVTLLTDLDLATLPENPREKQKAMALAVTASRHGMEAAQKAQLDAASLVGGAGDAATEVPGASLAEVNFPAKAFYLLSAVGICASSSEARRQIKGGAVRLEGEKIGDPNQEFASAAELEGKVLQLGKKTFRRLTA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHNA_ACISS
Sequence: MEKIMSNKFNNKVALITGAGSGIGKSTALLLAQQGVSVVVSDINLEAAQKVVDEIVALGGKAAANKANTAEPEDMKAAVEFAVSTFGALHLAFNNAGILGEVNSTEELSIEGWRRVIDVNLNAVFYSMHYEVPAILAAGGGAIVNTASIAGLIGIQNISGYVAAKHGVTGLTKAAALEYADKGIRINSVHPGYIKTPLIAEFEEAEMVKLHPIGRLGQPEEVAQVVAFLLSDDASFVTGSQYVVDGAYTSK
What is the function of this protein?
Catalyzes the oxidation of cyclohexanol to cyclohexanone.  Required for the conversion of cyclohexanol to adipic acid.
What are the official names of this protein?
Cyclohexanol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PG24_MYCTO
Sequence: MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGADEVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLLNIVNTPTQLLLGRPLIGNGANGAPGTGQAVGADGLLYGNGGAGGSGAPGQAGGPGGAAGLFGNGGAGGAGGDGPGNGAAGGAGGAGGLLFGSGGAGGPGGVGNTGTGGLGGDGGAAGLFGAGGIGGAGGPGFNGGAGGAGGRSGLFEVLAAGGAGGTGGLSVNGGTGGTGGTGGGGGLFSNGGAGGAGGFGVSGSAGGNGGTGGDGGIFTGNGGTGGTGGTGTGNQLVGGEGGADGAGGNAGILFGAGGIGGTGGTGLGAPDPGGTGGKGGVGGIGGAGALFGPGGAGGTGGFGASSADQMAGGIGGSGGSGGAAKLIGDGGAGGTGGDSVRGAAGSGGTGGTGGLIGDGGAGGAGGTGIEFGSVGGAGGAGGNAAGLSGAGGAGGAGGFGETAGDGGAGGNAGLFNGDGGAGGAGGLGIAGDGGNGGKGGKAGMVGNGGDGGAGGASVVANGGVGGSGGNATLIGNGGNGGNGGVGSAPGKGGAGGTAGLLGLNGSPGLS
What are the official names of this protein?
Uncharacterized PE-PGRS family protein PE_PGRS24.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family. PGRS subfamily.
Protein: MIAA_BURO0
Sequence: MSASSQSRPTTIACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRDMDIGTAKPSRDERASVPHHLIDIIDPADAYSAAEFRADTLRLIGEIVARGRTPLLAGGTMLYYKALTQGLNDLPGADPEVRAALDADAARDGWPALHARLAQVDPDTAARLAPNDSQRIQRALEIFMLSGQPMSALLAAPRRTDDAAAAYRFVPVALEPSDRAVLHARIAQRFDAMLDAGFIDEVERLRRRDDLHPDLPSMRCVGYRQAWEFLDGDTDYRTMRDKGIFATRQLCKRQITWLRAMPERIVVDCIAPDSTARALDALERVLDGRTPD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: OPSD_BUFBU
Sequence: MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSILCAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTVTMYSSMNGYFILGATGCYVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFSENHAVMGVAFTWIMALSCAVPPLLGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVFFLICWVPYASVAFFIFSNQGSEFGPIFMTVPAFFAKSSSIYNPVIYIMLNKQFRNCMITTLCCGKNPFGEDDASSAATSKTEASSVSSSQVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: YJJB_ECO27
Sequence: MGVIEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGSIGHGSRMILMTSGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMISAVKISQLGYSEPLMITLLTNFLTASSIVGALSIGLSIPGLWLYRKRPRV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADD_STRCO
Sequence: MGGTFDPIHHGHLVAASEVAAQFQLDEVVFVPTGQPWQKSHRAVSAAEDRYLMTVVATVENPQFSVSRIDIDRGGPTYTVDTLRDLRALNPDADLFFITGADALAQILTWRDSEELFSLAHFIGVTRPGHTLTDAGLPKGGVSLVEVPALAISSTDCRARVAKGDPVWYLVPDGVVRYIDKRHLYRGE
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: TRMD_CYAP4
Sequence: MRFDVVTLFPDFFTSPLASGLLGKALAKQIAEVYLLNPRDFTTDKHHRVDDESYGGGVGMVLKPEPIFAAVESLPVLPRREVILMSPQGERLDQALLQSLADNFDQLVVICGHYEGVDERVVDHLVTREISLGDFVLTCGEIPALTLLNGVIRLLPGTVGKAESLQNESFIDGLLDFPHYTRPADFRGWPVPQVLRSGHHAEVDRWRRTQQIQRTRDRRPDLYQRWLNSLPPDSLQDFTV
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_COXBN
Sequence: MTHSVQLKILDKRLGSEFPLPAYATKGSAGLDLRACLDEPLKIEPDETCLISTGLAIYLGHSNVAATILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGKEPYTINPGDRIAQLVVLPILKAQFAVVEEFELTERGAGGFGSSGQN
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: MURC_COXBR
Sequence: MQLDKKIINHVHCLGIGGIGVSALAEILLKKGCRVTGSDVSPNKNTERLQRLGAEIIFNHDGTAITQADCAVYSSAIGATNPELMAAKQAKIPLLKRGEMLANLMKEYQSIAVAGAHGKTTTSGMLSHAFVEANLDPTFMVGGVLNNSQTPARVGNGHYFIAEADESDASFLFMHPDIAVVTNIDADHLSTYDGDFNRLKQTYIQFLEQTAQDGVVVLCLDDPILREIAPLLSRRVITYGFSSDAQYRVVDYCQQGIQSLFQIHSPQRKAPLTVKLSMPGQHNALNATAVTAIADVVQMNEPALLKSLADFPGVDRRFTIRGEMILPKGNALIIEDYGHHPNEIKATLAAARAAWPERRMVLVFQPHRYSRTRDLMTEFVSVLAETDWLVLLEVYSAGEMPIPGADGMALIKMMSNGMAQKTTFVPLLQNLPETLQKLSQPNDIIILQGAGNIGSIVTALVQTHG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISXH_RUEPO
Sequence: MTITVLKSAPGLPPAPQGDAADVVQVMLARLRAEGEAAARDYAARLDGWSGEIVVSPDQVARASEQVPEDLKTQIRYAHDNIRRFAEAQRASALDFQTELRPGLIAGQKQIPLAAAGAYVPGGRYAHIASALMSIATARAAGVGQITAVSPPQVGRGVHPAILYAMSLAGADRILALGGVQGVAALAFGLFGAPPADILVGPGNQFVAEAKRQLFGPVGIDMFAGPTDSLVIADSTADPLTVAWDLVGQAEHGYNSPVWLVTDSAALAEAVLAHIPGCIADLPEPNRSSAQAAWDALGEVILCTDREEMAATADRYAPEHLHVQAADLDWWRGRLSAYGSLFLGELTTVAFGDKASGPNHVLPTSGAARYTGGLSVHKFLKTVTWQQVAPQALPDLARATATISRAEGMEGHARTADIRLEKLRPTLRQVGTG
What are the official names of this protein?
Histidinol dehydrogenase homolog.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: HSP83_LEIAM
Sequence: MTETFAFQAEINQLMSLIINTFYSNKEIFLRDVISNASDACDKIRYQSLTDPSVLGDATRLCVRVVPDKENKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGADMSMIGQFGVGFYSAYLVADRVTVTSKNNSDEVYVWESSAGGTFTITSAPESDMKLPARITLHLKEDQLEYLEARRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEEAKKADEDGEEPKVEEVTEGEEGKKKKTKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPPATKHFSVEGQLEFRAIMFVPKRAPFDMLEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLEMFEEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEVMTTLKDYVTRMKAEQNSIYYITGDSKKKLESSPFIEQAKRRGFEVLFMTEPYDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKRQREEEKATCEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQMMRNQALRDSSMAQYMMSKKTMELNPKHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLEDPTYAERINRMIKLGLSLDEEEEEEAVEAAVAETAPAEVTAGTSSMELVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
What are the official names of this protein?
Heat shock protein 83, HSP 83.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBBP9_HUMAN
Sequence: MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA
What is the function of this protein?
Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647).  May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647).  May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
What are the official names of this protein?
Serine hydrolase RBBP9, B5T-overexpressed gene protein, Protein BOG, Retinoblastoma-binding protein 10, RBBP-10, Retinoblastoma-binding protein 9, RBBP-9.
What is the protein family that this protein belongs to?
Belongs to the RBBP9 family.
Protein: MUCEN_PONAB
Sequence: MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTIKTSITTPNTESLQKNVITPTTGTTPKGKITNELLKMSLMSAVTLTSKDEGLKVTTTDVRKNESIVSNVTVTIVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSILQPDASPSETGTLSSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLVGLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN
What is the function of this protein?
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
What are the official names of this protein?
Endomucin.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RASU_DICDI
Sequence: MSAFIYNNSNNNNSMRLCVMGDGGVGKTSITIQFISNHFVNCYDPTIEDLYRKQCLIDDQVYMLDILDTAGQDELNAIRNHWIKSCEGFILVYSVTSRSSFDQIQSFLDQIKFLKSEKVPIIMIANKSDLDDERQVTYQEGENFANRFGMSFMEVSAKYKLNIDEVFNQIAQHCVKRRCDHIYINKSIRNKNSIFKKFNQKLNNTFHSICKMI
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
Ras-like protein rasU.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: PAFA_FRACC
Sequence: MDRRIFGLENEYGVTCVFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLKNGARLYLDVGSHPEYATPECDSVPDLVTHDKAGERILEGLLVEAERRLREEGIAGDIHLFKNNTDSAGNSYGCHENYLVGRHGEFSKLADVLVPFLVSRQILCGAGKVLQTPRGAVYCISQRAEHIWESVSSATTRSRPIINTRDEPHADAERFRRLHVIVGDSNMSETTMLLKLGATDLVLRMIEAGVMLRDMTLENPIRAIREVSHDMTCQRRIKLANGREVSALDIQWEYHSKAVEFVERRGGDGDEVAKRVLDLWGRTLLAIETDDLELVAREIDWVTKYVLIERFRHKHGLSLASPRVAELDLKYHDIHRDRGLYYRMERAGLVERVTRDLDVFEAKSRPPQTTRARLRGEFIKRAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVDKLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: GPA7_CAEBR
Sequence: MGHCTSKDQKEGKRLNRRIDEQIKKDQSMSLRIIKLLLLGAGESGKSTILKQMRILHKDGFSQQDLEMIRPVVYSNCIHSMLSILRAMFHLQIEYGEPDRVRDSQLVFATVHANKEELTEELAQAMQRLWHDPGVRECYRRSNEYQIDDSAKYFLDNLPRLSSPSYVPSEQDLLRTRIKTTGITEVLFELKGLTFRVIDVGGQRSERKKWIHCFDNVNAIIFISSLSEYDQTLREDNCTNRMQESLKLFDSICNSPWFADIHFILFLNKKDLFAEKIVRSPLTVCFPEYKGQQNQTECINYIQWKFEQLNRSSQREIYCHHTCATDTNNVQFVLDACLDMIIAKNLKSMGLC
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-7 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein: YD144_YEAST
Sequence: MSRILVIGAGGVGVITALSLWLKKESDVSLVVRSDYDRVLKHGYTIESCDYGRLEGWRPHHIYSSVEDAASAADNQGYNYIVVTTKNIIDGPVNSRVSNIIRPVLEKNKELHGPQLTTHILLVQNGIDIEKEIWAEFPREQYRYTVLSGIQLIGSTKIGSGHISQVGQDHLSCGAFDPQDAAAIQAANDFVRMYSNEGQNFVEFDPRVRYSRWKKLLYNAAINTSTALVGLDVPRCLEFGVNKKSTEIEVFHPAMREIIAIAASEGIIIEEEFITMFTEITRKKVFKPSMCVDCEKGQLMELEVILGNPIRIAKRNGVATPTLSILYNLLVLVQAKLKERKGLLKFDEKTATLVDE
What are the official names of this protein?
Uncharacterized protein YDL144C.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.