PharMolix/UniProtQA huggingface dataset:
Protein: HSP1_DASSP
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRGRRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CCG4_NEUCR
Sequence: MKFTLPLVIFAAVASATPVAQPNAEAEAQWCRIHGQSCWKVKRVADAFANAIQGMGGLPPRDESGHQPAQVAKRQVDELAGIIALTQEDVNAYYDSLSLQEKFAPSTEEEKKTEKVAKREAEAEAQWCRIHGQSCWKKREAEAQWCRIHGQSCWKRDALPEAEPQWCRIHGQSCWKKRDAAPEAAPEAEANPQWCRIHGQSCWKAKRAAEAVMTAIQSAEAESALLLRDTTFSPVDRVGKRDPQVCNMRLHPKKVCWKRDASPEAACNAPDGSCTKATRDLHAMYNVARAILTAHSDEN
What is the function of this protein?
Pheromone that is regulated by the circadian clock.  Expression is mating type specific and under the control of the mating type locus.  Involved in conidiation.
What are the official names of this protein?
Clock-controlled pheromone ccg-4.
What are the subcellular locations of this protein?
Secreted.
Protein: KR197_HUMAN
Sequence: MSYSGSYYGGLGYGCGGFGGLGYGYSCGCGSFRRLGYGCGYGGYRYSCCHPSCYGGYWSSGFY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 19-7.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 19 family.
Protein: HIS5_PYRFU
Sequence: MDRIAIVDLGIGNLANVKKALKGYITSDPYEIEKADKIVLPGVGNFGAVVDKLAPIKDIIIEGINEGKPFLGICLGMQLLFEESEESPGKEGLGIFKGKVVKLKNVRTPHIGWNQVWIKKECKLFEGLKNGSYFYFVHSYHAVPQDPDIIATTTDYENAEFVSSVCFENIFGVQFHPEKSSKNGLILLRNFRRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_ERYLH
Sequence: MAANSRKAAAILLSGGLDSMVTAAIAQEQGYAVHALTIDYGQRHKVELQSARLIAAKIGAERHVEIEADLRALGGSALTDDIDVPKCGVGNDIPVTYVPARNLVFLSLTTAFAEASGARDIFIGVNALDYSGYPDCRPEFIESFAVTANLATKAGVEESAPFKIHAPLQHMTKADIARECARLGLESAWSWSCYDPLPGLKPCGACDSCRLRRKGFAEAGLADGLDYPADAPPIQGENA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: TPS19_ARATH
Sequence: MEATRMGFGGLSVPLSLTPNLSLIPQRLLDKHNLSLKPVKIHHLVCVRSTKSSDDLETSRPSTYFSPSLWGDHFLSVSLDHAEFVELEREIETMKPLVKDMLMSSQSSDKEKIRLIHLLVSLGSSYHFDKEIQDILKHSFTKLDGIIVEEDDLETISIMFEVFRLYGHKMSCDAFDRFRGGDGRFKESLAKDVRGMLQLFEVAHLGTLSEDIMDEALRFTRNHLESLTSGNVSSASPHILKHIQNSLYIPRYCNIEVLVAREYISYYEQEEGYNEILLKFAKLNFNFCQCHYIQEIKTLTKWWKDLDLASKLPYIRDRSVESHLGGLGPYFEPQYSLGRIIVAKTIMIIVVADDTYDAHATIPEATVLTEYFQRLNIGADDKLSGYLRIVLESVFEVMGEIEQEMSPKGRSYSVKQVLERFKIIAKAYKQLTEWARKGHVPTFDEYMKVGLVTAGMGDYAGYCFIGMEDINEKEAFEWLNSNPLLIDALNVLFRIANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASRELRKMYIYNKKVVVEEFMNSHDRVPRQVLLRCLNFARLFDVIYTEGDGYSEPKGKIEHFMTSLYVHPIPLS
What are the official names of this protein?
Terpenoid synthase 19, AtTPS19.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPLP1_CAMFO
Sequence: MQCIPKKTFMAMLRIPEVRSNLAAYLRTALMVQEVKNHDDMVHLKALSSEENEDFEICIPGGTYLELFRNPVLRSHLSAMERSYKFPGRFLSEEVDSRDLIPESEKRSLATLAKNGDLPITIQERESDNDDEEKRSASSSDNVGSLHELFDEVSYRRRTPEIYDYLTEQDPEVLEYSPDKRNVGSLARDFALPTGRRHIASVARDHGLPSGKRNVGSLARQSMLPLSGKRNVASLARYYMLPQSGKRNVAALARDSSLPYGKRYLGSLARSGSYPTRDYDEGKRSIASLARSGDWPSVAKRGRMTSGRIMARVLNRRYGRSLSDDREAPSEPLDLQQLIRQGNSEGKENEWQATPFTVSEDLDEGKAKNRSNRRIEASQTRHKRQIDFSDEYPLPVMQNNMLDYEDMMEAIADHYPNAEKRFMGQTVSQPPLRVFRRVLFSYLDVMSTVFCRTCNQVEPHLLQTEKIYHIYVCQYQQIYQPHHVKDNPNTNEPTTMYNHYVQKKCSPMSSSSTHGIITVVRENPADGSSSNYTPDASTRSLRPIFTPKTRYLQSLHGDCRHGFKRFLLLPDIDNFLRTSNSHIAPRSM
What are the official names of this protein?
Neuropeptide-like 1.
What are the subcellular locations of this protein?
Secreted.
Protein: RR14_HELAN
Sequence: MAKKSLIQREKKRQKLEQKYHLIRRSSKEEISKVRSLSDKWEIYGKLQSPPRNSAPTRLHRRCFSTGRPRANYRDFGLSGHILREMVHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEUD_SYMTH
Sequence: MRPFTRETGLAVPLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATILIAGRNFGSGSSREHAPWALSDYGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMRRAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLHGLDDIGLTLQYEDEIAAYEARRPAWLPTTPAR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: LAP_YMTV5
Sequence: MSNICWICNDTCDERNNFCICSEEYKIVHLKCMQSWINYSKKVECDLCKNKYNIKKSYHYFSRWKWCFSDKKTVLSKILFIFFAVGFIFITTSMSSNVASLVTRIDDTFFDVVFLTVYISMILVTVCLCVFVLALAVDFLLDAKEKNSFLTIKEIV
What is the function of this protein?
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.  Binds target molecules through transmembrane interaction.  The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed.
What are the official names of this protein?
E3 ubiquitin-protein ligase LAP, Leukemia associated protein, LAP, RING-type E3 ubiquitin transferase.
What is the protein family that this protein belongs to?
Belongs to the poxviridae LAP protein family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network membrane. Host early endosome membrane.
Protein: Y4045_BACAC
Sequence: MGRKWNNIKDKKASKDANTSRIYAKFGREIYVAAKQGEPDPESNQALRVVLERAKTYNVPRTIIDRAVEKAKGGSEENYDELRYEGFGPNGAMVIVDTLTNNVNRTAADVRAAFSKNSGNMGVNGSVAYMFDATAVIGLEGKTSDEVLEILMEADVDARDILEEEDAVIVYAEPDQFHAVQSALKDAGVEEFTVAELTMLAQNDVTLPEDAQAQFEKMVDALEDLEDVQQVYHNVDLGE
What are the official names of this protein?
Probable transcriptional regulatory protein BAMEG_4045.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_CERS1
Sequence: MAADKQNLQDAFLNHVRKAKVPVTIFLINGVKLQGVITWFDNFCVLLRRDGQSQLVYKHAISTIMPGQPINLYEGDD
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: ARGR_SHIDS
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1299_STRP3
Sequence: MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGENIFCQITAVKRNFAEAKLLTVNKASKNRVKPACSVYETCGGCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPIDNCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVALNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGFAFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGKAEDIIPKWYKQGYRADAIIVDPPRTGLDDKLLKTILHYQPKQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV
What are the official names of this protein?
Uncharacterized RNA methyltransferase SpyM3_1299.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: HEM6_KLEP7
Sequence: MKPDAAQVKTFLLQLQDSLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGVNFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVYPRYKKWCDDYFYLKHRQEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYGERERHFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_RHOOB
Sequence: MVDPARARKLAKRIGTIVATAIDHEIKDPRLAFVTITDTKVTADLHDATVYYTVMGADLESEPDLVSAAAGLEKAKGVLRSKVGAGTGVRFTPTLTFVADTVPDTARHMEELLARARAADDEVARVAAGASPAGDPDPYKEPRVEDADDAEVDEPSRSRQAD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_ECOLI
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11, Large ribosomal subunit protein uL11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SLMA_SALSV
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKNTSTRLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDENLLASQLLAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL34_PSEMY
Sequence: MKRTFQPSTIKRARTHGFRARMATKNGRAVLSRRRAKGRKRLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TCPG_ENCCU
Sequence: MQKPIPRKMYILVPDKPAQIQNESAIAAKTISSVIRTCLGPRAMQKMVLTKINSIELTNDGNAILRELDVAHPSARSLIELAKTQDDEVGDGTTSVVLLAAEILNEMTYILDRDVHPIRICKALGRALEICIKAIDGAAISLDSNEETKIKIINGSVASKICNILKVPIGNLALEAVKKVYVKEENKCDLKNNMKVEKVLGGNLMESEVVDGVLINKDIIHPQMRRVIENPRIVIIESPLEYKKGESQTNYEFSKENDFTRALEIEEEQVREMCERIIGVRPDIVVCEKGISDLALSILFENNITGLRRLKKTDISRLSKVCGARSVSRPEDLEERHVGVSCGLFEYIKYGEEYYCKFSRCAHPKACSVVIRGPTKDILDELERNFMDAVKVAKSIFISPKLCPGGGAAEMAMAHELMQSAGDNEVEAEVFSRMASALTIIPSILLENSGVFNPLEAITLLEQKHKEGSFYGVNGTTGEIVDTRDLVLEPYAVKSQCIKSAVEAVSQLLRIDGIIESKR
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_ECO27
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDIVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: RS20_HALOH
Sequence: MPIIKSAKKRVRITEKRTAYNREWKEKIKQAIKEFEKVVEEGNVEEAEAKLREASKILDKSAGKGIIHKNKAARKKSQLTRQFNKIA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: TVC3_MOUSE
Sequence: MLLLRWFTSCCLWVFGLGQLEQTELSVTRETDENVQISCIVYLPYFSNTAIHWYRQKTNQQFEYLIYVATNYNQRPLGGKHKKIEASKDFKSSTSTLEINYLKKEDEATYYCAVYSSGFHKVFAEGTKLIVI
What are the official names of this protein?
T-cell receptor gamma chain V region DFL12.
Protein: TRUA_ECOL6
Sequence: MSDQQQPPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETTAQRKDAAWTLGVNANLPGDIAVRWVKAVPDDFHARFSATARRYRYIIYNHRLRPAVLSKGVTHFYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLMEVGAHNQPESWIAELLAAKDRTLAAATAKAEGLYLVAVDYPDRYDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SYN_ENTFA
Sequence: MNGETNVEQIQIIDSNKHVGETVKIGAWIANKRSSGKIAFLQLRDGTAFFQGVVFKPNFIEAFGEEAGTEKFQEIKHLSQETAVMVTGVIKEDSRSKFGYEMDITDLEVVGASEDYPITPKEHGTDFLMDHRHLWLRSSKQHAIMLVRNEIIRATYEFFNEQGFIKIDSPILTGSAPEGTTELFETDYFGQPAFLSQTGQLYAEAGAMAFGKVFTFGPTFRAEKSKTRRHLTEFWMIEPEMAYTTHEESLDIQEAYVKHLIKSVLKNQQYPLDVLERDTALLEKYVSEPFKRITYDDAIELLQKEEANNDYDHIEWGEDFGSPHETFISNYYGVPTFILNYPKAIKAFYMKPHPTREDVVICADLIAPEGYGEIIGGSERATDYDYLKEKVAEFGLSEEEYSWYLDLRKYGSVPHSGFGLGLERAVTFITGNEHIREAIPFPRMLNRIYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERCC5_MOUSE
Sequence: MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRDSHGNVIENAHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLAKRRQRKDSASIDSRKTTEKLLKTFLKRQALKTAFRSSRHEAPPSLTQVQRQDDIYVLPPLPEEEKHSSEEEDEKQWQARMDQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESNDFSQYQLKGLLKKNYLNQHIENVQKEMNQQHSGQIQRQYQDEGGFLKEVESRRVVSEDTSHYILIKGIQGKKVMDVDSESLPSSSNVHSVSSNLKSSPHEKVKPEREPEAAPPSPRTLLAIQAAMLGSSSEDEPESREGRQSKERNSGATADAGSISPRTCAAIQKALDDDNDEKVSGSSDDLAEKMLLGSGLEQEEHADETAERGGGVPFDTAPLTPSVTEVKECVTSGSSANGQTDSAHSFTTASHRCDTPKETVSLARAVKEASQISSECEVEGRPAALSPAFIGTPSSHVSGVLSEREPTLAPPTTRTHSDQGIDIHPEDPELQNGLYPLETKCNSSRLSSDDETEGGQNPAPKACSTVHVPAEAMSNLENALPSNAEERGDFQETIQLREVPEAAARELISAPKPMGPMEMESEESESDGSFIEVQSVVSNSELQTESSEASTHLSEKDAEEPRETLEEGTSRDTECLLQDSSDIEAMEGHREADIDAEDMPNEWQDINLEELDALESNLLAEQNSLKAQKQQQDRIAASVTGQMFLESQELLRLFGVPYIQAPMEAEAQCAMLDLTDQTSGTITDDSDIWLFGARHVYKNFFNKNKFVEYYQYVDFYSQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGRGLDPLLKFSEWWHEAQNNKKVAENPYDTKVKKKLRKLQLTPGFPNPAVADAYLRPVVDDSRGSFLWGKPDVDKISTFCQRYFGWNRMKTDESLYPVLKHLNAHQTQLRIDSFFRLAQQEKQDAKLIKSHRLNRAVTCILRKEREEKAPELTKVTEALDDAKGKTQKRELPYKKETSVPKRRRPSGNGGFLGDPYCSESPQESSCEDGEGSSVMSARQRSAAESSKISCSDVPDLVRDPPHGRQGCVSTSSSSEDDEDKAKTVLVTARPVFGKKKLKLKSMKRRKKKT
What is the function of this protein?
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair.  Makes the 3'incision in DNA nucleotide excision repair (NER).  Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble.  Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA.  Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes.  Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II.  Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity.  Required for DNA replication fork maintenance and preservation of genomic stability.  Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site.  During HRR, binds to the replication fork with high specificity and stabilizes it.  Also, acts upstream of HRR, to promote the release of BRCA1 from DNA.
What are the official names of this protein?
DNA excision repair protein ERCC-5, DNA repair protein complementing XP-G cells homolog, Xeroderma pigmentosum group G-complementing protein homolog.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with RAD51 to nuclear foci in S phase. Localizes to DNA double-strand breaks (DBS) during replication stress. Colocalizes with BRCA2 to nuclear foci following DNA replication stress.
Protein: MARK1_HUMAN
Sequence: MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
What is the function of this protein?
Serine/threonine-protein kinase (PubMed:23666762).  Involved in cell polarity and microtubule dynamics regulation.  Phosphorylates DCX, MAP2 and MAP4.  Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).  Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly.  Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX.  Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
What are the official names of this protein?
Serine/threonine-protein kinase MARK1, MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par-1c, Par1c.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite. Note=Appears to localize to an intracellular network.
Protein: PYRH_PROM3
Sequence: MAYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVMNAITLQDGLERAGVATRVQTAIEMQEVAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATKVDGVYDRDPKRFPDAKRYDSLTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HM20B_HUMAN
Sequence: MSHGPKQPGAAAAPAGGKAPGQHGGFVVTVKQERGEGPRAGEKGSHEEEPVKKRGWPKGKKRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLMNTLLNGHKGGDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNAVLQRHTQSMSSARERLEQELALEERRTLALQQQLQAVRQALTASFASLPVPGTGETPTLGTLDFYMARLHGAIERDPAQHEKLIVRIKEILAQVASEHL
What is the function of this protein?
Required for correct progression through G2 phase of the cell cycle and entry into mitosis.  Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein, BRCA2-associated factor 35, HMG box-containing protein 20B, HMG domain-containing protein 2, HMG domain-containing protein HMGX2, Sox-like transcriptional factor, Structural DNA-binding protein BRAF35.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
Protein: YQCG_ECOLI
Sequence: MSEENKENGFNHVKTFTKIIFIFSVLVFNDNEYKITDAAVNLFIQI
What are the official names of this protein?
Uncharacterized protein YqcG.
Protein: DEOD3_SHEON
Sequence: MTAHINAQPTDFAETVIMPGDPLRAKYIAETYLTDAVEVTNVRNMLGYTGYYQGQRISVMGHGMGISSMVLYGHELINFFGVKRIIRIGSLGATQQHVEMRDVILAQAAGTDSPTNAKRSSGYHMATSATFSLLHKAYTKANEKGISVKVGNVFSGDLYYDPDEDMIPALERFGVLGIDMEVAGLYGLAHQQGIESLAILTVSDHCLTGEETTAQERQLSFNNMIELALETALN
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.