Protein: SHP2A_DANRE
Sequence: MAAVGPASPPPPPLWMHRDLSRAAAEELLARAGRDGSFLVRDSESVSGAYALCVLFQKHVHTYRILPDEENFLAVQTSQGVQPKRFKTLPELIQLYLQPSQGLVTTLLYPVEREETTEDRDYSDGEDEKPPLPPRTASTSSMTGSALVSTDTPPENVTAANGLSTISHEYLKGNYALDLEAVKQGANSLPHLNKTLLSSCKRLHGEVDKVLCGLEILSKVFDQQSASMVSRMIQQSMSQGGDQELEHLVTKLAILKDLLSSIEKKALKALQDMSSSTPAISPLLSIRNKVIPVQTFEVKLDVYLADLTKIGKSQKYSLSVDVEGGKLVVMKKMKDAQEDWNTFTHDKIRQLIKSQRVQNKLGIVFEKEKDKSQRKDFIFASAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGSVPAPKPLGSWILSRGLGKTLDEMAVTIPHDIYVFGTQENSVCDKEWVETLRCSLKEYTDMEYKPIAVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKIHRRNQNYLDILRQLSLGDKQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILNYINRKEFDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSWCDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFGTFEVGVTSQFVSKKGLPKSSEQAYIEFENIEAIVKTASRTKFFIEFYSTCLEEFKKSYENDTQSSDNVNFLRVGWSSKQLTTLKPILSDIEYLQDQHLLLTVKSLDGYESYGECVLALKSMIGSTAQQFHTYLSHRGEETGNIRGSMRVRVPSERMGTRERLYEWISVDKDDMGGPKGRTLPPRTSHDYVKPTSSSSSRKHGSAELSRVSEEGEKSSTSRHTHTKEENTHNRGKQDPFESDATTCKNSFNNPAYYILEGVPNQSAALASDILPGSALPPLANKTTAPPAGSVGKSKPPSGSSAQGRWQTSGRSVRPISEEGSSEDDGNIGPHTGSLNRPPPDFPPPPLPKAALEMSENSFGKPRVFSDLADGKIPPPSKPLVSPGLTPPPGGAPGGGVAFCIESPPVLSPNSAPFRRGGGASALDDQSCSVLQMAKTLSEVEYPSGRERGASQGPTGPQLRGLSFPSHPIQEESIAEDLPEEGGLWGAESSSSSLSVDCSVGEWLQKLGLQHYEEGLLHNGWDDLEFLSDITEEDLEEAGVRDPAHKKILLASLKQQQK
What is the function of this protein?
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.  Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear.  Part of a signaling pathway that regulates actin cytoskeleton remodeling.  Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation.  Participates in regulation of cortical and submembraneous actin.  Regulates cell adhesion and cell spreading.  Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A).  Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems.  May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity).
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A, Inositol polyphosphate phosphatase-like protein 1A, INPPL1-A, SH2 domain-containing inositol 5'-phosphatase 2A, SH2 domain-containing inositol phosphatase 2A, SHIP-2A.
What is the protein family that this protein belongs to?
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Nucleus. Nucleus speckle. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type.