Protein: MYCA_MYCTT
Sequence: MVQTPRQKKFGNEPIAIIGSACRFPGAASTPSKLWELLRKPKDLLTKIPPNRFNADSFYHPDGAHHGASNVTESYFLEEDPRLFDAAFFNVKPVEAHSIDPQHRMLLEVVYESLEAAGQSIEGLAKSQTGVFVGLMCADFSDHILRDLDAIPTYMATGTARSLISNRISYFFDWHGPSMTIDTACSSSLFAVHQAVQLLRSGDSDLAVAAGSNLILGPELYIGESKLKMLSPTGRSRMWDADADGYARGEGVAAVILKRLSDAIRDGDHIESIIRESGINSDGRTKGLTMPNELAQADLIVRTYQKAGLDPTKEEERCQYFEAHGTGTEAGDCREAEGISRAFFGYQGGNEGPAPPSQSEKLYVGSIKTVVGHTEGTAGLAGLLKASLAIQHSTIPPNMLFERLSPKVAPFYKGVEIATEAKPWPKASDVRRASVNSFGFGGANAHVILENYEPPAVAAAGTGAGAGDAASQTSFTPFVFSAASETALEGVLEAYAAHLRENPDLPLRDLSYTLHSRRSALGVRAALPAVASTQQLANSISDHLELARAGRNDKSAGQGASIGSRPIAATPRLLGVFTGQGAQWAAMGKELIQGSAFVRDRIKSLESALSDLPASARASWSLTDELLADAASSRLGEALLAQPLCTAVQIVLVDLLREAGIEFAAVVGHSSGEIAAAYAARIISAEEAIKIAYYRGLCVEEHVKTEGAMMAVGTSYEDATELCNLDAFSGRLGIAACNSPSSVTLSGDAAAIREAKDILDDEKKFARPLKVNKAYHSHHMAACSAPYKQALEACNIEPRQLAEEEGGCVWYSSVYPGTAMGTTAAHIEDLKGEYWKDNMLRPVLFAQALETAIERNEDSPFNLVIEVGPHPALKGPASETLTALYGKKQLPLPPYTGTLSRGSGDIAALSVTLGTAWSRFGSPFVNFAQYEALLTGEPRSARKVVPNLPTYKWDHDKVFWHDTRLSRAMRNRKELPNPLLGRRIPDGVTDEMRWRNIIRPSELPWISGHQLQGQMVYPAAAYLSTAIEACAFLAEGSVVESVEIRDFDLGKALVFDGNTEQTGVETLFSLSNIVKKGPKQITANFAFHAALGADADVLSRLGSGRVIVTLAGTGTGAGTGRLLLPPQRAPEPADTAEVREDEFYASLEKLGYEYTNDFRALSGMRRKLDHGSAYVRVPGHELAADAVLVHPALLDCALQAIFLAYWYPNDGSLDQLQVPTGIASLTVNTSLCRQDLAEGVRLPLESFLTEDPLSTATIGGDVEVYGRDGRTPLIQVQGVRITPLATRTGQADRQLFMENVWGPGAPDGTLAADNRAGAADFELASDLERLTIYFMRKLVRDIPPSQRQGLEWHHEALFDFVEHVLEQTANGRQRFCKPEWLDDTWESISHIRAKHPDSIEVELTHAVGENLAAAVRGETQILQHMFKDNLLNRYYVEALGIRETTAFLARTVAQIVHRYPHMDILEIGAGTGGATKAIFREIGRTFSSYTYTDISTGFFEKAQEVFAATADKMIFRALDIEKDVVEQGYREGAYDLIIGSLVLHATKSLDKTMRATRRLLKPGGYLVLLELTNLDVLRTGFAMSGLPGWWLGRDDGRRYSPCATSARWHQVLLGAGFSGIDTITPEVDVLPRPFSVIVSQAVEPRVNLLREPLSHPAESNASAADGGELVIVGGQSLATVILIDSVLDLTRHFGFAVTRLSSLDEFDAAAVSPTALVLNLAELDQPVFSNLTGETMRGLQSMLDYQRTILWVTQGCRAEQPYMSMSVGLGRTVALEAPGVKLQFLDLDISRKPNSKLVAEALIRLRFTRDEGSTRGILYSTEQELVEDDGRILVPRLLPIRPANERYNSSKRKITKLTEVGAESPALVLASTDAGYAVYEGASDDARAGASDDTAIIRVTASTLLPVIGNLYGVLGQEKDSGSWVLGLSSTNGSHVAVPRGQVRLVGDAILKEEAQQQQRLLLLALLAVEAQSSQILSAVPRDSKLLVNEPPAGLAGSLVRRAAERGTTVVFTASTTDAADLGLPHGHPVVSLSPLSSKRAVRAALPADVALFLDCSAEPEGVGLGSLIAACVPPSGQSIKLAELGEKLRQQPTLVDAPPSDTELASLPTLVDWSSGDKVPVSLQSVDSLIRFDGAKTYVLFGLTSDLGRSLVDWMASHGARNVVMTSRRPNIDPKWLEERRARGIRIQAFANDITDPAAVEDLVNSIRRSFPPIAGIMHGAMVLEDVPFSEMSLEIMNKVVRPKVMGTIHLDRLFQDEQLDFFVFFSSLASASGNRGQSNYSAANMYMTAKTFERRRKGLAASVLHLGAVMGIGYVMREASEIVFPAIRRAGFQWMDERAFRQCVAEAILAGRPDSGRSPEIVTGLRVINVDEEEPAPWMDNPRFQHCIVRGGTDSGAKKNQGGAAAGVKTRLLEAATPEEVLDIIRDSFLQKLQIMLQTELQTDDERANILAANAEDTGIDSLVAVEIRSWFQKEMDVDVPVLKILGGATMADLVAFAHEKLPEGLTPNLGNESAAAAAAAAAERSQSRVEITPAPDAVDTSRTSTTVFSAPPTLDPASSSTGSDHPTSVTSSGHTTPAHELETGLSPPSAPPCAPREQDVERTAPMSLGQSRFWFLRSYIEDQTTFNISFSVRLKGPLQVDKLESAIQTLGHRHQALRTAFVARPGQLLPDQAVLKRSLLRLEKRQIKEAAEASEAFEAMKNYVFAIERGESMRLVLLSLSPSDHFLVVGYHHINMDGASLEVFMADLMKLYTGRPLAPRPFQYPDFAAQQQLEVQQGKMDRDIAWWQDQLAGAALFRLLGTGDLCIGMADANRFEGDLASSVGMYLNLLPLRFRPSGDRTFRDTLKDVRRTAYAAMAHSHVPFDLVLNNLKIQRSTLHSPLFQAFINYRAGVAEKRSLGAVEGEGEQYHFGRSAYDISLDIMENPNSDPRLMFLVQEQLYSEHEANILADTYMHLLDLFARKPDSTLGSAPAFAPETAEEAIRLGRGNPVVSDWPQTIVHRVDDIIQRNPDTIAVREALGGRVWNYRQLRDRVGAIARALLAAGVTGGSRVALFQEPGFDWVSSLLAVMRVGAVFVPIDPGTPVERLAVIAAAARPAVALSHDATESAQEAALAVIRDAGGARVVNVSRGEGEGEGDVAGAGAPANLAQPDEAAVIFFTSGTTGVPKGAIVPHRGITNFMEHTCDIRGPEVVLFHSALGFDLAMWQCFSGLAHGGTLVVAPRSMRGDPVAITGLMAKEKITCTGATPSEYHTWIQYGFSKLAQSTSWRIAMTGGEQCTPKLVDDFRSLRLPGLRLWNCYGPSEVTVGSNQAEIPLSEPPQAPVTVGKAMPNRSVYILDDRLEPVCAGAPGEVVIGGVGVGLGYLGNDHLTAEKFVPDPFAPAGGSAKMYRTGDRGRLTRDGELEILGRIDGDSQIKLRGIRIEMQDVEQAILRSADGALASVCVTARGEPPTLVAHAVFRPDAPVPRRDRDAFLRRLASSLPLPQYMHPAVIVEIPSMPLNLHGKLDRRAVQELPTRVVAAKEEEEEKRPNGSSAAPLTQQELQLRSRVWERVIPEDVLSLYTVDRDTDFFHVGGNSMLLVEVQRRVKDEFGANLTIMRLFENSTLGAMAAAVHDAALESAGVDAAIDWEDETALTKDLADAVPSPEERAAAGRRRLDNNGPGGKVVVILTGATGFIGRELLARLLSSPDVAEVRCIAVRDPSRLADVVESNPGRVSVHAGDLTSVEETVGEEDEQRLFADAHAVIHCGADVSFLKTYATLRRANVGSTKALARLALRHGLDFHYVSTAATGRLLLVADPSSSPTARGDVFGEESVAAYPPPPGWLDHYVASKWASEAFLERAAARLGLRVWVHRPTSVTGPGAGETDVMSTVMRFAKKLRAVPVSSRWRGSLDFVPVETVADGIVGAVIRGGREHQQQQQQQETTPEEAGSVVPVKFLHHSGGLVIPIERLQSHLEEEDGVEYRTVPLGQWIEMAVAEGLNVLVAAYLASVDEMDTDIVFQAYVKG
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of myceliothermophins, mycotoxins that contain a trans-fused decalin ring system connected to a conjugated 3-pyrrolin-2-one moiety and that have potential anti-tumor properties (PubMed:27960349).  The polyketide synthase module (PKS) of the PKS-NRPS mycA is responsible for the synthesis of the octaketide backbone (PubMed:27960349).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the octaketide with a leucine (PubMed:27960349).  A reductase-like domain (R) at the C-terminus catalyzes the reductive release of the polyketide-amino acid intermediate (PubMed:27960349).  Because mycA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase mycC (PubMed:27960349).  Following mycA-catalyzed construction and release of aminoacyl polyketide aldehyde, Knoevenagel condensation yields the expected ketone (PubMed:27960349).  This C18 keto acyclic precursor is the substrate of the Diels-Alderase mycB, that catalyzes the Diels-Alder cycloaddition to produce myceliothermophin E (PubMed:27960349).  A yet unknown oxygenase involved in the production of myceliothermophin A, via substitution with a hydroxyl group at the C21, has still to be identified (PubMed:27960349).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase mycA, Myceliothermophin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.