PharMolix/UniProtQA huggingface dataset:
Protein: ISPF_FRAP2
Sequence: MSFRIGHGYDVHKFTSTKKNIILGGIEIPYEMGLEAHSDGDVLIHALCDAILGALCLGDIGKHFPDTDMEYKNTDSKFFLAEIKKMLDDKEYSISNIDCTIIAQAPKMLPHIEKMKACLASVLEIQINQINIKATTTEQLGFIGRKEGIATHVVCLLNR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: SYR_CERSK
Sequence: MNLFTEIRTLVTAELGAMTEAGDLPAGLDLSAVAVEPPRDPAHGDMSTNAAMVLAKPSGKPPRAIAEALATRLAADPRISSAEVAGPGFLNLRLRPAVWQGMVATILKAGDTYGRSTIGAGQKVNVEFVSANPTGPMHVGHVRGAVVGDALARLLAYAGWNVTREYYINDGGAQVDVLARSAFERYREAHGLEPEIREGLYPGDYLIPVGEALKAKYGDSLLDKGEQHWLTEVREFATEMMMQMIREDLAALGVEMDVYSSEKALYGTGKIEAALDRLKEMDLIYEGVLEPPKGKTPEDWEPREQTLFRSTAHGDDVDRPVKKSDGSWTYFAPDIAYHYDKVTRGFDQLIDIFGADHGGYVKRMKAAVAALSAGRVPLDIKLIQLVKLWKNGEPFKMSKRAGTYVTLRDVVEQVGTDVTRFVMLTRKNDATLDFDFDKVLEQSKENPVFYVQYANARINSVLRKAREQGMDVSDATLATADLDRLDHPAEIALIAKLAEWPRLVEIAARTNEPHRVAFYLHELASELHGLWNRGNDEAGLRFLQEDPVVSQAKIALARAVGVVICAGLGILGVTPVEEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VU84_HHV6U
Sequence: MKDRGNKNTSKTRQTVKSRRTRKTTKQFVERKKNLSAKTTIRNNRLQNNLSPQTTPTEKPVDYATARVFPQHTPYDIKFNKEKYRNNEIYAYSKLRKISNAVFRQEKEINRLTVFTDKPLADLSFKMPVNTSTTEKKEIVRSTECQRQDRNTVNAFKIFQSYETSPPYSPCSPKNFMSEIYRLFRCYNASIVQIQVYSRNKILINAMQEKLMSIGNMVINVGEQIISESVHHEPVVAIAINQFFRGTVPQTDALRKNAVTPIPVNASKKKLVGICSLMINAPTEKDLLCAAHVCINFAICYPNEITLNIAKLTQPMLLQEHITIYNSFNKYIYWDDYGKLLN
What are the official names of this protein?
Protein U84.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U84 family.
Protein: Y2537_LEPBL
Sequence: MSGHSKWATIKRKKDAIDSKRGAIFTRVGKEITVAAKMGGGDPEGNPRLRLAILKAKSVNMPKDNIERAIKKGTGELEGVVYEECLYECFGPAGIAIMVSAVTDKKSRTTPEIKSILTKLGGSLATSGSVSRLFEKKGVIVLESSQIGEDKLVDLAVGEGAEDVINEGEVYRVITTPDDYESVLHALNEKGLKSEESEIRYIALISSEIADKEVAKKVMKLIEQLDGHDDVTSVTSNFELAASLEKEFE
What are the official names of this protein?
Probable transcriptional regulatory protein LBL_2537.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_RAT
Sequence: MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L3, L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: RIMO_CARHZ
Sequence: MKYFILSLGCTKNQADSEVIMGILESKGYVRSLNPEESDLLIVNTCGFIAAAIEESIEEILNLVHLKKPGQKILVAGCLVQREGKELAKHLPEVDLFFTPREINNLDKLLADLGENNKLVLSEPGFLNLEKKPRAKSNEVYRYIKIADGCDNRCTYCTIPAIRGKYTSRPLDDILEEIKDTLKQGIKEIILVAQDTTAYGIDLYGEFKLVELLRKIGSIKGNFWVRLMYLYPDKITPELINEIKENPKVIKYVDVPLQHIHPEILKKMGRKGSSEEIISTLERLRKEIPDITIRTTFIVGFPGETEEQFNYLLDFVKKFKFNRLGAFPYYREKGTPAAKMKGQIPKKVKEQRYEKLMEVQQEISLNLNKALVGKKIPVIVEKKIRGENLYLGRTYMDAPEIDGIIEIKAEKRLKKGQIINVLITDYDIYDLKGEFIND
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBOA2_RAT
Sequence: MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAVWFRTYLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGISYCIMIIAGVESMHQCCFVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYEIHDGMFRKDEELTPSQRGLAVRRMPSLLEYVSYTCNFMGILAGPLCSYKDYIAFIEGRASHMAQSGENGKEEQHGKAEPSPNAAVTEKLLVCGLSLLFHLTISSMLPVEYNIDEHFQATASWPTKATYLYVSLLAARPKYYFAWTLADAINNAAGFGFRGYDKNGVARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERATFSPTVQTFFLSAIWHGVYPGYYLTFLTGVLMTLAARAVRNNFRHYFVEPPQLKLFYDIITWAATQITISYTVVPFVLLSINPSFTFYRSWYYCLHICSILVLLLLPVKKSPRKKNTEENAQPSWAKKFDERENSLGQNSFSMMNNVCNQNQDTGSRHSALTQ
What is the function of this protein?
Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.  May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS).  Prefers oleoyl-CoA as the acyl donor (By similarity).  May be involved in chondrocyte differentiation (By similarity).
What are the official names of this protein?
Lysophospholipid acyltransferase 2, LPLAT 2, 1-acylglycerophosphate O-acyltransferase, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoethanolamine O-acyltransferase, Lysophosphatidic acid acyltransferase, LPAAT, Lyso-PA acyltransferase, Lysophosphatidylcholine acyltransferase, LPCAT, Lyso-PC acyltransferase, Lysophosphatidylcholine acyltransferase 4, Lyso-PC acyltransferase 4, Lysophosphatidylethanolamine acyltransferase, LPEAT, Lyso-PE acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 2, O-acyltransferase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Endoplasmic reticulum.
Protein: DAPB_NEUCR
Sequence: MPSTYSDDNTLRSGLDRFRDHSPSQHRRSMSQETDSTVSTTSIVFDRIQERLDTKEFPARGTDGDDNDSLKDELNNDDLETGPFLGNASPSSRSNQRSSADGQRMDRSLRRWLFIVSGALVATWVIGLIFFVSSKAYKPSSSFAHDPQATVTHGSGKKVTLDQVLNNEWRAKSHSISWIAGVNGEDGLLLEKEGANKDYLVVEDVRAQNPSSVEASKSKTLIKDKLFEFANKTYWPTVTVPSRDLKKVLLATDVQNNWRHSYYAVYWIFDVETQQAEPLVPYDADARLQLASWSPTSDAIVYTRDNNMFLRKLDSDKIVQITRDGSADVFNGVPDWVYEEEVLASGVATWWSEDGNYVAFLRTNETGVPEYPIQYFVSRPSGEEPKPGEENYPEVRQIKYPKAGAHNPIVDLKFYDVKRGDVFSVDISGRFADDDRLITEVIWAGKQVLIKETNRVSDVMRVVLVDVGSRTGKAVRTVDVNDIDGGWFEISHKTKFIPADPANGRPDDGYVDTIIHNNGDHLAYFTPLDNPNPIMLTSGDYEVVDAPSAVDLQRNLVYFVSTKESSIQRHVYQVKLTGEDMTPVTDTSKEGYYAISFSTGAGYALVSYQGPNIPWQKVISTPSNPDKYEHVVEENKDLAEAAKKHELPINIYGTINVDGVELNYIERRPPHFDKNKKYPVLFQQYSGPVSQTVKKTFAVDFQSFVAAGLGYICVTVDGRGTGFIGRKNRVIIRGNLGTWESHDQIAAAKHWAQKDYIDEDRLAIWGWSYGGYMTLKTLEQDAGQTFKYGMAVAPVTDWRFYDSIYTERYMRTPQTNPEGYESAAVTNVTALSQNVRFLLMHGVADDNVHMQNSLTLLDALDQRSVENYDVQVFPDSDHGIYFHNANRIVFDKLTNWLVNAFNGEWLKIANAQPNGMKRRALPTA
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: RR4_NICSY
Sequence: MSRYRGPRFKKIRRLGALPGLTNKKPRNGSDLRNQSRSGKKSQYRIRLEEKQKLRFHYGLTERQLLKYVRIARKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPAARQLVNHRHILVNGRIVDIPSYRCKPRDIITAKDEQKSRALIQISLDSSPHEELPNHLTLHPFQYKGLVNQIIDSKWVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FMAG_ASPFU
Sequence: MAYELSTLQLSCVAFVAFMAVLVFRTRTRNLKQNVPPGPRPLPIIGNFFDLPPKGQPEYLHWFKHKDAYGPVSSINVMGTTLVIFHDKDAAHAVMGKKAQKTSARPQLNFAQLCGFENFLITHQYNDKYRLHRKMVHQEIGTKGLSAGFRPIQEQESIRFILQTFNRPDDILQHLKTLAAAIVLKITYGYSIERKGQDPLVELIEHAMENLSQAFVPLAWAVDSVPAIKYLPDWFPGMSYRKTARKWRAINEAAAELPYDFVKRQMAHKAHQPSYVSNLLEKHMIKSEDNKINVSAADEEAIKWTAVSLYAAGSDSTVAIIHSVICGLVMFPEVVTRAQEEIDRVVGSDRLPNFDDRTNLPYVDGIIKEAWRWNPVGPMGLTHKSEEDLVCGEYLIPKGSYLLPSLWWFLNDPKEYPEPRVFKPERYMEPFNHPDPSEIAFGYGRRSCAGRYFADASVYITVVQLLAVFNVRKARDDQGNEIPVTLQAIPGMVNRPAPFQFKVEPRSQHHIDLLRRIESEQIPEVSHASLLKPSTV
What is the function of this protein?
Multifunctional cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the multifunctional cytochrome P450 monooxygenase af510 acts as a 2,4,6-trichlorophenol monooxygenase that first performs the C-H hydroxylation at the bridgehead C5 position to yield 5R-hydroxyl-beta-trans-bergamotene (PubMed:24568283).  Subsequently, a four electron oxidation initiated at C-9 coupled to cleavage of the cyclobutane C5-C8 bond of the bicyclo[3. 1. 1] core yields the epoxyketone intermediate 5-keto-cordycol (PubMed:24568283).  An additional epoxidation reaction also catalyzed by af510 then furnishes the characteristic bisepoxide ketone 5-keto-demethoxyfumagillol (PubMed:24568283).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Multifunctional cytochrome P450 monooxygenase af510, 2,4,6-trichlorophenol monooxygenase, Fumagillin biosynthesis cluster P450 monooxygenase, Fma-P450.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYFA_STAAU
Sequence: MSEQQTMSELKQQALVDINEANDERALQEVKVKYLGKKGSVSGLMKLMKDLPNEEKPAFGQKVNELRQTIQNELDERQQMLVKEKLNKQLAEETIDVSLPGRHIEIGSKHPLTRTIEEIEDLFLGLGYEIVNGYEVEQDHYNFEMLNLPKSHPARDMQDSFYITDEILLRTHTSPVQARTMESRHGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNVKMSDLKGTLELLAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSSEYSGFAFGMGPDRIAMLKYGIEDIRHFYTNDVRFLDQFKAVEDRGDM
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3A_CANGA
Sequence: MAPPPLRPENALKRADELISVNEKPAALQSLYEFITARRIRYATPSQVEPIVFKFLELGVELKKGKLIKDALYQYKKLVHGSAEGLVSVGAVLRKFIDYVETKLASEQAKAEEKQKEEVSDDLEGGVTPENLLSSVYEADHSVAGFNDEALNSWMRFSWESYRTALDLLRNNSQLEITYSGVVSRTMQFCLKHQRKNEFKRLAEMLRQHLDTANYHQSKFGSNQVDLSDADTLQRYLDQRFQLVDASVKLGLWHEAYKAAEDVYHLMKMTTRKPKSSTLANYFENLVQIFLVSGDQILHTLAWKKYFELYSTNPNATEEEFKKIASTIFLSALSIQLDDLPNVRYNYQSRSYRLLDVETKPTRKEVIQSIVEDDTIFSRVDAETKTLYEIMEVEFDGESFKGKFEAILPKLEGESYFANYSVSLRDVIIRRMFVFASQKYEDISLNDLYSSVTFSSSFKLSEWDIEKQLLQAAVDDYVSFQLDHEQNKVTFVKDPLVNFAAIKEEEVEEEEEEEEEEEEEEKEAEGAEGAEGDTEEGQEAVAEPEPVIKRNYYIRKRLSELYEKLLEDTDYNTVSYLDKVRIAREALIKHTKDTIEDMKKNSEERAKMHQERRRQHMESAAMNAEKDAEQRQKRIMEERASIEAKLEEEAHRRLIEKKKREFEEVKQREIRKLVDELNAKGNGTKVEYDEVKDMDIPDITKYFVNRLSKNKDELEERMNFAVKRMDHLERAYRKVELPLLKKQADELRATDEVNFGNMKKKIVDAAKAEYEAKMEDYNRVSSVFDDYKTLRDRMLAAHNEKFAAIRAENAAKLEAAKKARIEEVRKQRYEELLARSEAEKKAAEEAERRAKLDEIARKQREMEEALERKSAARTFTQPRAPVVPNANLDEIARKQREMEEAIERKLAGKSAAPAPAPAPAASTPAASTPAAPGKMSFAERMRLKRQQQQQK
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIA7E_HUMAN
Sequence: MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAAESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF
What is the function of this protein?
Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675).  GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).  Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).
What are the official names of this protein?
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, GD1 alpha synthase, GalNAc alpha-2,6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: EGLN3_RAT
Sequence: MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHYNGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAINFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFVADVEPIFDRLLFSWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALAKD
What is the function of this protein?
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (By similarity).  Target proteins are preferentially recognized via a LXXLAP motif (By similarity).  Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184).  Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity).  Also hydroxylates HIF2A (By similarity).  Has a preference for the CODD site for both HIF1A and HIF2A (By similarity).  Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (By similarity).  Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity).  Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity).  ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia (By similarity).  Also hydroxylates PKM in hypoxia, limiting glycolysis (By similarity).  Under normoxia, hydroxylates and regulates the stability of ADRB2 (By similarity).  Regulator of cardiomyocyte and neuronal apoptosis (By similarity).  In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813).  In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:10386996, PubMed:11060309).  Also essential for hypoxic regulation of neutrophilic inflammation (By similarity).  Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity).  Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
What are the official names of this protein?
Prolyl hydroxylase EGLN3, Egl nine homolog 3, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3, Prolyl hydroxylase domain-containing protein 3, PHD3, SM-20.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm.
Protein: LEU1_LISMH
Sequence: MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEGDIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFEVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFQTRMEEMGYNLSEQELKDAFKRFKQLADAKKEVTEDDLHALILGQSSESADDFELKHLQVQYVTGGVQGAIVRIAERDGTLIEDAATGSGSIEAIYNTINRLMKQNIELTNYHIQAITAGQDAQAEVHVVIKDKSGAEFHGIGIDFDVLTASAKAYLQASAKSKTGSKQADFEEVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: KV5AL_MOUSE
Sequence: DVQMIQSPSSLSASLGDIVTMTCQASQGTNINLNWFQQKPGKAPKLLIYGASILEDGVPSRFSGSRYGTDFTLTISSLEDEDMATYFCLQHTYLPYTFGGGTKLEIKR
What are the official names of this protein?
Ig kappa chain V-V region W3082.
Protein: PSBA1_SYNP2
Sequence: MTTTLQQRGSASLWEKFCQWITSTENRIYVGWFGVLMIPTLLTATTCFIIAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVIFHFLIGVFCYMGREWELSYRLGMRPWICVAFSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLGAWPVVGIWFTALGVSTMAFNLNGFNFNQSILDSQGRVINTWADILNRANLGFEVMHERNAHNFPLDLAAGEQAPVALQAPAING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 1, PSII D1 protein 1, Photosystem II Q(B) protein 1.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: Y472_MYCTU
Sequence: MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator Rv0472c.
Protein: RNH2_STRPN
Sequence: MATIKEIKEFLVTVKELESPIFLELEKDNRSGVQKEISKRKRAIQAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILSKNCKIKGLNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSPQPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELLKEYDQQFPGYDFATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMRP1_MACFA
Sequence: MFLFSRKTKTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMEQHVDPEALQKMAKCAVQDYTYRGPISGHPYLPEKYWLSQEEADKCSPNYLGSNRYNTWRMEPYNSSCCNKYTTYLPRLPKEAGMETAVRGMPLECPPKPERLNAYEREVMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCRELPTLCTSLRAPARNAVCCYNSPAVILPISEP
What is the function of this protein?
May play a role in spermatogenesis.  May be involved in differentiation or function of ciliated cells (By similarity).
What are the official names of this protein?
Spermatid-specific manchette-related protein 1, Ciliated bronchial epithelial protein 1.
What is the protein family that this protein belongs to?
Belongs to the SMRP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Note=Localizes to the manchette in elongating spermatids. Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (By similarity).