PharMolix/UniProtQA huggingface dataset:
Protein: NRDI_YERPY
Sequence: MNPLVYFSSSSENSHRFVEKLQLPAIRIPIAGAREKLRVEQPYILLVPSYGGGSPVGAVPIQVIRFLNDVHNRSLIRGVIAAGNTNFGDAYCLAGDIISHKCQVPYLYRFELLGTAEDVANVRKGVTEFWQRQN
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: VATD_ARCFU
Sequence: MAEVQPTRMELIKLRRRIKMATRGHALLKMKRDGLIMEFRQLLEEAKEVIGGMVQKYEKAQSKLALAIAVDGIVAVRSIALSCCQIPPEFSMKRKNIMGVVVPVIKREPIRKKPTERGYGILSTSTRVDEAVEAYEELVDAVLEVAEIETTLRKLIEEIERTKRRVNALEYRVIPTMEELAKFISFKLEEMDRENIIRLKKLKMKKAKS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: BIOW_METM5
Sequence: MFSLKMRASRNGNHVSGAERLVNEEKIEKISSELIKRAMSHENGVPDFINLKIEKVTEKINKLKHLEIKTVHSTSKENSRNIARNLLKNELEKYYLKNGKDIEKIDELIDFAFKIIDAGNMRGAAILDLDGNRLENILERGIRVKNIDTTEELSEKILKDSSLTERTVDAIAIATKVVNCGVISELCTSDNFSYTTGYVATKDGYFRILNLKDKGQVGGRVFFVENSKIDELYDKLENMPVTVY
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: RL391_ARATH
Sequence: MPSHKSFMIKKKLGKKMRQNRPIPHWIRLRTDNTIRYNAKRRHWRRTKLGF
What are the official names of this protein?
60S ribosomal protein L39-1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: THSA_THEK8
Sequence: MAQLSGQPVVILPEGTQRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDGATILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYALAAEKAQEILEEIAIKVNPDDEETLLRIAMTSITGKNAESHKELLAKLAVDAVKQVAEKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVEGAKIALINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDDLAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEIVEERKLAGENMIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAISVDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEILVKVISEHKNKGLGIGIDVFAGEPADMLERGIIAPLRVTKQAIKSARAAIMILRIDDVIAAKVSKPEGRQGAECPPNGCMGGMDMRM
What is the function of this protein?
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
What are the official names of this protein?
Thermosome subunit alpha, Chaperonin subunit alpha, Thermosome subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
Protein: ENO_STRPG
Sequence: MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DRE2_CANGA
Sequence: MAKSGLLLIHPAITTTPEEVEKAKADAVAADVKIANQFLINKVNEGSVKLQKGIYDVIYYLTPEAPDAILFPKKLIGALNEALKVGGVLYGLSDKYKIDALVNDFDIVSDSGKYHWVKKVNMAVKAEPVAVPLKKSEKSEPSKTLPSFKKAGESKLPSFKKAANKPLPTFKKKVEEAKPKVEARVHKAENDDDELEDEEDENLFDASRSKYFDEDDSESLDEDDLLNEEDAKNIGGITMITCGKSKTKKKKACKDCSCGIKEEEEAEIDNIRSQQDTVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCTGCPYLGLPAFKPGEPINLDSITDDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: DYLT5_MOUSE
Sequence: MAQTHGSKQQAQRLEQGAESLRHGAQAQSRENNVSLSTVSHADEPSQRDESSRLTVRMENTYQLGPTKPFPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQRDDQSIVIGSRCLWNPKSDTVSSYTFKNSTFFALANVYAVYFE
What are the official names of this protein?
Dynein light chain Tctex-type 5, Tctex1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
Protein: BRK2_PHYSA
Sequence: RPPGFSPFRIY
What is the function of this protein?
May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle.  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Phyllokinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACPS_VIBC3
Sequence: MIVGLGTDIAEIERVEKALARSGENFARRILTDSELEQFHASKQQGRFLAKRFAAKEAASKALGTGIAQGVTFHDFTISHDKLGKPLLTLSGQAAELASQLQIENIHLSISDERHYAMATVILERR
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_KLEP7
Sequence: MKKQAELYRGKAKTVYSTDNPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMSKLAEAGIPTQMEALLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNDSYCETFGWVSKENLARMRELTYKANDVLKKLFDDAGLILVDFKLEFGLFKGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVAHRLGVKLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CDC62_SULTO
Sequence: MKVLDELRDLVEDAIKGSTVFEKSKVLTPDYIPKNLPHREKQIKELSINFREILSNPGSTSVRVVISGKTGTGKTVTTKKFGELFSEIAKEKGLRVVYTHINCHRQRTLYLMLVEIANQLNLQIPNRGLSSQETFKLIYDYLEKRNIQLIITLDEFDYFVSTSPVEDIYFLVRIYDELNALVKRIHYIFILRELTSLASLDKSIKDHVIKNVIEFPPYTSEELYDILMDRIVNEKAFREGAVLEETVRFISDIYGIDKGGSGNARLALETLELAGKIADTEGSLLVTIDHAKKANSKINPELSIILDTIRDLDLHQLLVVKAIMNLHKKEGDDFFSMGKVEEEYNIVAKDLGEIPRKHTQVFEYIRKLKLMGLITARQSGKGMRGRTTLISLSVPISEELDNLINNEIRDRLLQQKNY
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 2.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: MTNB_XYLF2
Sequence: MNATCTPSLPYDASRLRELAHLLIGTISEFAQAGWTPATSSNFSHRLDEHHVAITVSGRDKRCLREEDIMAVDLDGNAVGHPHTPSAETLLHTQLYRRFPEIGCVLHTHSLTQTVASRVYAGAGHISLKDYELLKAFAGHSTHETTLDVPVFCNTQNMNILAAQVDTLLDKQRMWGYLINGHGMYTWGNTLADARRHLEALEFLLHCELDLLKLRGYL
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: DTD3_SYNY3
Sequence: MHLVDTHVHINFDVFAADLDQLQHRWRQAGVVQLVHSCVKPQEFDQIQSLADRFPELFFAVGLHPLDAEDWQDNTAGQILAYAKADDRVVAIGEMGLDFFKADNRDHQIEVFRAQLAIARELNKPVIIHCRDAAQTMRQVLTDFQAESGPVAGVMHCWGGTPEETQWFLDLGFYISFSGTVTFKKAEGIQASAQMVPPDRLLVETDCPFLAPVPQRGKRNEPAFVRHVAEAIAALRHVPLETLAQQTTTNARNLFKLPVPA
What is the function of this protein?
Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr).
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, D-tyrosyl-tRNA deacylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. DTD3 subfamily.
Protein: Y393_STAAB
Sequence: MNNFRQCALCIGTSVLILLVSGCSGVFDTPEDSKETQIKKSFAKTLDMYPIKNLEDLYDKEGYRDGEFKKDDKGMWTIYTDFAKSNKSDELDDEGMVLNLDRNTRTAKGYYFVKKFYEKDKFSDRKNYKVEMKNNKIILLDKVNDPNLKERIENFKFFGQYANFKDLENYNNGDVSINWNVPSYDVEYKMSNKDENVKQLRSRYNIPTDKAPMLKMHIDGDLKGSSVGYKRLEIDFSKEDRDISVIDYLSYKPAKK
What are the official names of this protein?
Uncharacterized lipoprotein SAB0393.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y679_RHOPA
Sequence: MQTSTEVVPPLMSRFRPSAAPRKPAPFLPMSRAEMDKLGWDACDIVLVTGDAYVDHPSFGMAIIGRLLESQGFRVGIISQPDWQSAEPFKALGKPRVFFGVTGGNMDSMVNRYTADRRLRHDDAYTPNGEGGKRPDRCTLVYAQRCREAFKDVPIILGGIEASLRRIAHYDYWSDKVRRSVLADAKADLLLYGNAERAVIEVAHRLAAGEAPRELEDIRGVALFRRVPENTIELHADDLDAADEGARQVRGDVVIRLPSCEQVEQDKEAYARASRVLHRESNPGNARPLVQRHGDRDLWLNPPPIPLTTEEMDSVYDLPYARAPHPSYGNAKIPAWDMIKTSVTIMRGCFGGCTFCSITEHEGRIIQSRSEASILQEIEKIRDKTPGFTGVISDIGGPTANMYRMACKDSNIESSCRKPSCVFPDICPNLNTSHDDLIRLYRKVREVKGIKRVMVASGVRYDLAVKSPAYIKELVSHHVGGYLKIAPEHTERGPLDKMMKPGIGTYHRFKQMFEAAAKQAGKQYYLIPYFIAAHPGTTDEDMMNLALWLKRNRYRADQVQTFLPSPMATATAMYHSGVNPLRGVRHGASEPVEAIKGLRQRRLHKAFLRYHDPDNWPVLREALKAMGRADLIGSRPDQLVPAHQPPGTGKAAGTRRPVRGDGPKPQRFTTKGVRLVK
What are the official names of this protein?
UPF0313 protein RPA0679.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: RL32_PSEA8
Sequence: MAVQQNKKSRSARDMRRSHDALESNALSVEKSTGEVHLRHHVSPDGFYRGRKVVDKGSDE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL36_YERP3
Sequence: MQVLSSLRSAKNRHPDCKIVRRRGRVYVICKSNPRFKAVQGGTHKKR
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: THII_STRPG
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAITVRSDRDRTHVSLNGTDYQPVVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_HELPY
Sequence: MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTLLPDASSDIQKEIYRFKDHGDRDVALRFDLTVPLARFVSLHHQTLGMPFKRYAIGNVFRGERAQKGRYREFTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSINHRKILNGICEYFGISQVNEALRIVDKLEKIGLNGVEEELKKECGLNSNTIKELLELIQIKQNDLSHAEFFEKIAYLKDYNENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVCSGGRYDHLTKNFSKENLQGVGASIGIDRLIVALSEMQLLDERSTQAKVLIACMHEEYFSYANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVAVIGEEEFKSETLSLKNMHSGMQLNCLSFLKALEIIGENDEDL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1658_SERP5
Sequence: MQLSTTPTLEGFTITEYCGVVTGEAILGANIFRDFFAGVRDIVGGRSGAYEKELRKARLIAFKELEEQAKELGANAVVGIDIDYETVGKDSSMLMVTVSGTAVKVSR
What are the official names of this protein?
UPF0145 protein Spro_1658.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: FBSP1_DROPS
Sequence: MVDRVAALCNYNVLEVVFSYLDLNDLGRCSQVCKSWFHFLNDENSDVWRFHCLNKLPKEVTKSELLSPVPTYKTKLRAFFHSWNPSDCSRNVYIKPNGFTLHRNPVAQSTDAARAKIGFRHGRHAWEVIWEGPLGTVAVIGISTKEAALQCHGYVALLGSDDQSWGWNLVENHLLHNGDMQGGYPLLNNAPKYQVGERIRVILDCDDNTLSFEKNYEFLGVAFRGLPDKKLFPTVSAVYGNTEVSMVYCGTPLDG
What is the function of this protein?
Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).
What are the official names of this protein?
F-box/SPRY domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the FBXO45/Fsn family.
What are the subcellular locations of this protein?
Synapse.
Protein: TRMD_MYCTA
Sequence: MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRERRPDLSHPD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB32C_DICDI
Sequence: MYSNKNDKDKDKDQNNENNKNNDDEAISLKILVVGKLACGKTSIIQRYCHNNFQPKYKPTIGVDFQQKVLEIMGQKVLLQLWDIAGQERFGHMTRVYFQNAHGAVIVFDATRSGTFLGAKAWKDDIDYCFNNENLPTILLANKCDLLTPPYTFPEDINTFCEQNRFNKYFYTSAKEDTGINEALEELVKIILESYQTQEQSTGFKLSDQSQSTETTPTQSKTCC
What are the official names of this protein?
Ras-related protein Rab-32C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
Protein: LFTR_PARPJ
Sequence: MVPWLGPDDPFPPVERALGATSGAPGLLAASGDLLPSRLIDAYRRGIFPWYSDGQPVLWWSPDPRMVLRPAEFKVAPSLRKTLRRVLREDAWEIRVDHDFASVMRACAQAPRRGQRGTWITADVVEAYSSLHRVGDAHSIETWFEGKRVGGLYGVSFGKMFFGESMFAEVTDASKMALAALVGHLRRHEIEMIDCQQNTSHLASLGGREITRKSFIAHVRASVEAPPIPWRFDKTALLEVVAPAS
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_LEGPH
Sequence: MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNLRLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLALDKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGGKGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKTRVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICKVQGISEQLAKRIYEHFHP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_SHEPW
Sequence: MKPLNVIFAGTPDFAARHLQALIESQHKVIAVYTQPDRPAGRGKKLQSSPVKALALENDIPVLQPKSLRDETAQQELTALNADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDAETGVTIMQMDIGLDTGDMLLKTQLKIEDTDTSATLYEKLADQGPSALVEALAGIAADTLPAEKQDESLANYAEKLSKEEAQIDWSKSAEALWREIRAFNPWPVSHYQHAGNTIKVWQSHVSEKTSTAAAGTVISADKNGIDVATGNGVLTITSMQLPGKKPLSVADILNSRADWFTAGTQLNNAMGDQG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SYFA_SHIB3
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRLFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_SHEPA
Sequence: MTAQNIDGKAIAQSIRTQLKDKVTARKEAGKRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLDSSTSEDALLSLIDECNEDPTIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLLKSTGVDTFGLDAVVVGASNIVGRPMSLELLLAGCTTTTCHRFTRNLEDKVRSADLVVVAVGKPGFIPGDWIKPGAIVIDVGINRLESGQLVGDVEFDVASQHASFITPVPGGVGPMTIASLLENTLYACEQYHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: NRAM_I05A1
Sequence: TIGSICMVIGIVSLMLQIGNMISIWVSHSIQTGNQNQVEPISNTNFLTEKAVASVTLAGNSSLCPIRGWAVHSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGMITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGVKGFSFKYGNGVWIGRTKSPNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVSWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: TRM1_PYRAE
Sequence: MRHLVLRREGGVKFYAPDPEKYGGIYSAPVFYNPAMEKNRTLSTLLLKAYGKGGLVVCEPLSGTGVRGIRYAVESGVVGKLILNDISKEAVELIKKNLEINGVDAEVYNEDANVLLHKLKDSCDVVDIDPFGSPAPFIHGAFRALKEEGLICATATDTAVLVGRYPRKCLRRYGSVIVKTPFYIEVGLRNLLGYIARVAAAEDYKITPLMSYWEGHYFRVCAYAARGARDADDNFHHIAYIKYERGVRKILHAQSEGSSGPLWVGPLGDPLIINKMSEIGPYQDFLKILAEEYSISAPWFYRLPEFAAGGKSPTLKEAVGVLRAAGIYAVRTHMAPDGFKADGEYGEVLMAFKRYISSAHSLQ
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: DER_CROS5
Sequence: MALPIVAIIGRPNVGKSTLVNRLAKDRQAIVHDQPGITRDRTYRPAFWCDRDFQVVDTGGLVFDDDTEFLPLIREQAMAALTEASAAIFVVDGQLGPTAGDREISDWLRRQKVPVLLAVNKCESPEMGLIQAAEFWELGLGEPYPISGIHGSGTGELLDQLITYLPSPDELPDREEINVSIIGRPNVGKSSLLNAFLGEQRAIVSPISGTTRDAIDTVVERGDNTYRLIDTAGIRRKKNVNYGAEFFSINRAFKAIRRADVVLLVIDAIDGVTDQDIKLADRIIDEGRAAIIVVNKWDAVEKDSYTIYDYKQKVMDRLYFMEWADIIFVSAMSGKRVENIFELVDVAVEEHRRRVNTSVVNEVLEEAVKWHSPPTTKQGKQGRIYYGTQVSSQPPTIALFVNDPKRFNDNYRRYIERQFREQIGFPGTPIRLLWRGKKTRDVEPSLNRATKV
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: H2B2_ORYSJ
Sequence: MAPKAEKKPAEKKPAEEKAGEKAPAAGKKPKAEKRLPASKGEKGGEGKKERGRKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGEAAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.