PharMolix/UniProtQA huggingface dataset:
Protein: I23O2_HUMAN
Sequence: MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
What is the function of this protein?
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).  Involved in immune regulation.  May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).
What are the official names of this protein?
Indoleamine 2,3-dioxygenase 2, IDO-2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
Protein: HEM3_SYNY3
Sequence: MTVSTSAPTVRIGSRKSQLALVQTYWVQEELQKHFPDRQFDVETMETQGDKILDVALAKIGDKGLFTQELEDGMLGKRTDLAVHSLKDLPTNLPAGLMLGCVTKRVNPADALVLNAKHQGKDLASLPEGAVIGTSSLRRLAQLRYHFPHLTFKDVRGNVNTRLAKLDSNEYDAIILAAAGLERLDMANRIDQLIPPEISLHAVGQGALGIECREGDQEILSLLKVLEDENSRDRCLAERAFLRQLEGGCQVPIGVNTHLDGDNLTLTGMVASLDGQRLIKDTLSAPRKEAEKLGQDLALKLREQGAGEILAEILAEAGRG
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MIRC_ASPFU
Sequence: MPFLDHRTGPSYGTIDQMEQHSDDEGERFLQEQCDTGRFSSDITSISEDSVQEGVRKIEAINLTWTARSLVIAYVSIFLMSFCTSLEGQTVMSLGAYATSAFSKHSLISTVLVVQNVVNAVIKPPMAKVADVFGRFEAFCVSILIYVLGYIQMAASTNVQTYASAQIFYSAGSTGLQILQQVFIADSSNLLNRAFLALLPEFPFLVTVWIGPTIADAVLKHASWRWGYGMWSIILPASFLPLALSLLLNQRKARRLNLIKPKSRPRGGVFAVLRRTWYDLDMGGLILLSAAVTLILVPLTLAANSKNGWKSDSIVAMIVVGLFCLIALPFWESSKRLAPKPLLSLHLLKQRTALAGCTLAFWYFMAFYFSVQPYFYSYLQVVQGYDVATAGRVTQTFAFTSTIAAFAVSILIKYTRRYRAFVIAGCVVYIIGMVLMMVTRHEGSTPAQILVTQVVVGIGGGLLNVPVQLGVQASASHQEVAAATAMFLTSMEMGGAVGAALSGAVWTHNIPRKLRLYLPEENKGDADAIFGKITKALSYPLGSPVRVAINQAYQETFKKLLILALIAIIPLVPLSLAMEDYKLDKMSEEPLVDPVPAEEGEIEPNRHVKRT
What is the function of this protein?
Major facilitator transporter that contributes to the maintenance of intracellular siderophore ferricrocin (FC) levels (PubMed:28367141).  Plays a role in conidiation and confers protection against oxidative stress (PubMed:28367141).  Contributes also to fungal virulence in the Galleria mellonella animal model system (PubMed:28367141).  Does not appear to play a role in either siderophore export or uptake (PubMed:28367141).
What are the official names of this protein?
MFS siderochrome iron transporter C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=localizes intracellularly, possibly to vacuole-like structures, but not found in the plasma membrane or at the nucleus (PubMed:28367141).
Protein: SYR_MARMS
Sequence: MNIQTLLNQRIQAAMVAAGASDTAQALVRQSAKVQFGDYQANGIMGAAKALKMNPCDFAQATLDKLDLSDLAEKVEIAGPGFINIFLKNVWLSKELTQLRTSERLDVNPVDAPETVVVDYSSPNLAKEMHVGHLRSTVIGDAVVRTLEFFGHHVVRQNHVGDWGTQFGMLLAYMERLRSENATISMALSDLETFYRAAKTCFDEDEAFATRSRELVVALQSGDEECLALWDEFINISLTHCEETYKMLGVSLERQHVMPESAYNDDLANVVNELKEQGLLQESNGAQCVFMEEFANKEGEITPIIVQKTGGGFLYATTDLAAVRFRQHTLNANRVLYFVDARQSLHFQQIFTLSRKAGFVKPETQLEHMPFGTVMGSDGKPFKTRSGGVAKLSSLLEEAQERAYQLVASKNPEMDEEELRNIGRVVGIASVKYADLSKNRTSDYVFNWDSMLSFEGNTAPYLLYAYSRVASIVKRSEIDVVNLTGEISIDEPQERALAVKLCQFEEAIQQVANDGMPHFLCAYLYDLAGTFMTFYEACPILNAEDEVKHSRLQLALNTASTLKLGLSLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_BORGP
Sequence: MKEALTSLFEKVTKLPTTSGCYKMLNENKKILYIGKAKNLRSRIKSYFLEKKSHKIKILMKNVKSIEVITTNSEYEALLLECNLIKTHKPDYNVKLKDGKGYPMIRITHEKYPRILKTRKIINDQSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNAPCLYYHMGQCLGVCYKENLEKEYQIEVNKAKSILNGNISEILSQIDIKLKLAVQKEDFETAIKLKEMKSSLIEINQIQIVTKANNLNIDYVYVHPGENVNTIIVLKYRDGKLVERDANFDESICKKDELVLQFLIQYYTSINMIVPDKIHIFLKDVDTKNVEKLINEIKNTKTEIIYKETKEILKIMEMAISNAKLSLREYENKSNKALESLKIFLEMDKLPKIIEGFDIAHLKGQETVASMVTFKMGIPFKENYKLYKLNSLLKGEIDDFRAIKEAILRRYSEIINKKLELPNLILIDGGKGQLSAAFSILKSLKIEDKVKVCSLAKKHETIFLITNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLYKKIDGVGEKTAQKILKLIGTYKDILPLSENEISEKIKVNIKLAKRIKEFAIKENSIKNIDNDK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDJC_THEP3
Sequence: MKYLIVNADDFGLTKGVNKGVVECYKNGILRSTSIMCNMPYANEALQVKELCPDLGFGIHITLDAGKPLSSPEKVNTLVDERGYFKRGFPHSLDDADVDQIRIEIEEQIKKAFSLGVTITHMDSHHHAQSHSKVIDAFIEMAHKYNLPVRSTPLDKEKIIKAGLKTVDNFIYTFYDDGVKKENLLSILGSLEEGTTEIMSHPAYVDDELVNISSYHAKREVERKILTDKDVLQFIRDNNILLTNYSILK
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: ERMM_STAEP
Sequence: MNEKNIKHSQNFITSKHNIDKIMTNIRLNEHDNIFEIGSGKGHFTLELVQRCNFVTAIEIDHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYKIFGNIPYNISTDIIRKIVFDSIADEIYLIVEYGFAKRLLNTKRSFALFLMAEVDISILSMVPREYFHPKPKVNSSLIRLNRKKSRISHKDKQKYNYFVMKWVNKEYKKIFTKNQFNNSLKHAGIDDLNNISFEQFLSLFNSYKLFNK
What is the function of this protein?
This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
What are the official names of this protein?
rRNA adenine N-6-methyltransferase, Erythromycin resistance protein, Macrolide-lincosamide-streptogramin B resistance protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Protein: Y955_LISMH
Sequence: MAKMTILKMKARLEKELDAPNRQFAYNRDNDTLSVTQNGKKVTLTIPQIVANYENDGDAAVEKIVYYVEEGFRAAAGNVELKNNQANIYPVVRATSFPSKTKAGEVLLTDEHTAETKIFYAFDLGKSYRFIEEGMLEKAQLTHKEIREAAFRNLANLAIPLKKDAVNGNDFYFVRTNDGYDASRLLNEAFLREMREKITGEMVLAVPHQDVLIIGDIQDNTGYDVLAHMTMDFFADGLVPITSLPFVYNNGKLEPIFIMAKNRLKE
What are the official names of this protein?
UPF0354 protein LMHCC_0955.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: MURQ_COLP3
Sequence: MNTQAKLVNELKNITTEGQNPNTLDIDLLDSLGVLKKINTEDQKVASIVGLLLPEISQGVDLIVDAFACGGRLIYIGAGTSGRLGVLDAVECPPTFSVSSEQVIGILAGGAGAMYKAVEGAEDNRQLAIDDLKAINLSSKDIVVGIAASGRTPYVISGMAFAREQGAKVIGVSCSANSSYAQNCDINICAVVGAEVLTGSTRMKSGTAQKLILNMLSTASMIRSGKSYQNLMIDVNASNKKLYARAVRIVMQATECDFDTAEMALAQANNQTKLASLMVLTGLDSTQAKAALASNKGFLRKAVEQQGC
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: DDBX_BOVIN
Sequence: MDPKGQRVKLNDGHFIPVLGFGTFAPREVPKSEALEVTKFAIEAGFRHIDSAHLYQNEEQVGQAIRSKIADGTVKREDIFYTSKLWSTSLRPELVRPALEKSLNNLQLDYVDLYIIHFPVALKPGETLFPTDENGKPIFDSVDLCRTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYFNQSKLLDFCKSHDIVLVAYGALGSQRLKEWVNPNLPFLLEDPVLSAIAKKHRQTPALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTPEDMKAIDGLNSNMRYNELLLGVGHPEYPFVEEY
What are the official names of this protein?
Dihydrodiol dehydrogenase 3, Prostaglandin F synthase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_DESAH
Sequence: MIQTIRGFRDILPGETPLWQTIERAASQLFEDFGFQEIRLPLIERTELFARSIGEVTDIVEKEMYTFPDRKGENITLRPEATASVVRSYIQHKMYAADPIQKLYTMGPMFRRERPQKGRYRQFFQINAEVFGIASPYIDAQLILLLNELFKRLGLTDLTAHLNSLGCRECRPLFHRALTEFLVSKQDRLCSDCRRRMDKNPLRTLDCKVPGCREAMQDAPTTLDHLCSDCSDHFTTVKATLKAQGVDFLVDKTLVRGLDYYSRTAFEIQTTALGAQSAVAGGGRYDALIKELGGPEVPAIGFAIGLDRLAEVMAQLKGCPAPRGPDLFIIPLGPGAMEKAYLCSSRLNLVGIRSETDYNGKSLKSLMKRADKLNAGHALILDYRQPDKNAPVLRNMKTREQVTLGLEDPTDEVIKILTNEGTLRD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_SALEP
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: HSLU_RICM5
Sequence: MKATKTTYKKDPMGLTPSQIVNELNRFIVGQEKAKKAVAIALRNRCRRKRVEGNLRNEIVPKNILMIGSTGVGKTEIARRLAKLTNSPFYKIEATKFTEVGYVGRDVESIMRDLVEIAVNTEKTLAKTKVDINAREKAIERILDSLVGKTSSSETREKFKEKILNGELDDTEIEISVADTTPVGSGSFEIPGMPGASMGVLNLGDMIGRALGSSKTKTKKMLVKDAMAIIIPEESEKLIDQEKIIQQAINLAENDGIVFIDEIDKIASTGSSGAKNAEISREGVQRDLLPLIEGTTVNTKYGPVKTDHILFIASGAFHIAKPSDLLPELQGRLPIRVELNSLTKDDMIKILLEPETSLIKQYSALIGTEDVCLEFAASAIEKIADYAITVNLEVEDIGARRLHTILENLLEDISFEASEMKGKKITIDDKFVENQLSKIITNLDLAKFVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_SULIM
Sequence: MLIIIRPSGEIALKSPRSRRNFEHTLANNIRSVIKEGKIWRSQGVLFLEVNDDNKNIEELSKVFGIASFSPVMSIKSYNNNLEDIINKAKEVFAEIVKGKIFSVRAKRIGSHNFTSLDVQRKVGEALYPFSRGVNLENPEVEVFIEIRNDVAYFYHKIIKGPKGLPVGVAGKTVVLFSGGIDSPVATWMMMKRGSIPVILNFNLGGSVHRKFVLEELSVLRKWSGGHKLKLFIVNGTDVLIKLSQIEKRNRVVMLKRVMYKVAERLCDKANAKSITTGESLSQVSSQTMTNLYVTEYGIKYPIFRPLIGFDKEEIVELARKIGTYEYSIKLPEYCAISTKARTSVELDEVLKDEENLNIDYEKVLENSEVIEI
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2F1_PLAOK
Sequence: MVSKIRTFGWVQNPGKFENLKRVVQVFDRNSKVHNEVKNIKIPTLVKESKIQKELVAIMNQHDLIYTYKELVGTGTSIRSEAPCDAIIQATIADQGNKKGYIDNWSSDGFLRWAHALGFIEYINKSDSFVITDVGLAYSKSADGSAIEKEILIEAISSYPPAIRILTLLEDGQHLTKFDLGKNLGFSGESGFTSLPEGILLDTLANAMPKDKGEIRNNWEGSSDKYARMIGGWLDKLGLVKQGKKEFIIPTLGKPDNKEFISHAFKITGEGLKVLRRAKGSTKFTRVPKRVYWEMLATNLTDKEYVRTRRALILEILIKAGSLKIEQIQDNLKKLGFDEVIETIENDIKGLINTGIFIEIKGRFYQLKDHILQFVIPNRGVTKQLVKSELEEKKSELRHKLKYVPHEYIELIEIARNSTQDRILEMKVMEFFMKVYGYRGKHLGGSRKPDGAIYTVGSPIDYGVIVDTKAYSGGYNLPIGQADEMQRYVEENQTRNKHINPNEWWKVYPSSVTEFKFLFVSGHFKGNYKAQLTRLNHITNCNGAVLSVEELLIGGEMIKAGTLTLEEVRRKFNNGEINF
What is the function of this protein?
An S subtype restriction enzyme that recognizes the asymmetric double-stranded sequence 5'-GGATG-3' and cleaves respectively 14 bases after G-1 (top strand) and 13 bases before C-1 (bottom strand).
What are the official names of this protein?
Type II restriction enzyme FokI, R.FokI, Endonuclease FokI, Type-2 restriction enzyme FokI.
Protein: YCF68_ORYSJ
Sequence: MAYSSCLNRSLKPNKLLLRRIDGAIQVRSHVDLTFYSLVGSGRSGGGTTAPLFSRIHTSLISVWRAISRAQVEVRPQWENGAPNNASSQTKNYEITLSFWGDGGIVPFEPFFHAFPGGLEKAAINRTSLILPS
What are the official names of this protein?
Uncharacterized protein ycf68, ORF133.
What is the protein family that this protein belongs to?
Belongs to the ycf68 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NDST3_MOUSE
Sequence: MSFIMKPHRHFQRTLILLATFCMVSIIISAYYLYSGYKQESEVSGRASEVDCGDLQHIPSRLMEVRRTMISDASRTDPTVLVFVESQYSSLGQDIIMMLESIRFHYHTEIAPGKGDLPALTDNVKGKYVLIIYENILKYINMDSWNRSLLDKYCIEYGVGIIGFHKTSEKNLQSFQFRGFPFSISGNLAVKDCCINPHSPLLRVTKSSKLDRGSLPGTDWTVFQINHSTYQPVIFAKVKTPENLSPPISKHAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRTQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLIEQMILNKKFALEHGIPTDMGYAVSPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPRELDKSIHGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVQTWTNLRLQTLPPAQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALCLFLIMHPSILSNSPSPKSFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEDAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPNAPWELRTLQKRCLVPGWYANHIERWLVYFPPFQLLIIDGQHLRTTPATVMDEVQKFLGVSPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRAFLSSYYRDHNVELSKLLHRLGQPLPSWLRQELQKVR
What is the function of this protein?
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate.  Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.  Has high deacetylase activity but low sulfotransferase activity.
What are the official names of this protein?
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3, Glucosaminyl N-deacetylase/N-sulfotransferase 3, NDST-3, N-heparan sulfate sulfotransferase 3, N-HSST 3.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. NDST subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: GLI3_MOUSE
Sequence: MEAQAHSSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAITMQPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEADKDESKQEPEVIYETNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIKLERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKTKMALLGEGRDSGVTLPPVHPPRRCSDGGGHTYRGRHLMPHDALANSVRRASDPVRTVSENMSLARVQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTMDADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVGQEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPSAQQPRGFGLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQMGQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPSSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCSTVQNYSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGNGTENSELLSPGANQVTSTVDSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ
What is the function of this protein?
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development.  The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor.  A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity.  In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation.  Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
What are the official names of this protein?
Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3-190, GLI3 full-length protein, GLI3FL.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium. Note=Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity). GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO.
Protein: PCYB_SPHSK
Sequence: MARVTTGITSSHIPALGAAIQTGTSDNDYWGPVFKGYQPIRDWIKQPGNMPDVVILVYNDHASAFDMNIIPTFAIGCAETFKPADEGWGPRPVPDVKGHPDLAWHIAQSLILDEFDMTIMNQMDVDHGCTVPLSMIFGEPEEWPCKVIPFPVNVVTYPPPSGKRCFALGDSIRAAVESFPEDLNVHVWGTGGMSHQLQGPRAGLINKEFDLNFIDKLISDPEELSKMPHIQYLRESGSEGVELVMWLIMRGALPEKVRDLYTFYHIPASNTALGAMILQPEETAGTPLEPRKVMSGHSLAQA
What is the function of this protein?
Responsible for the aromatic ring fission of protocatechuate.
What are the official names of this protein?
Protocatechuate 4,5-dioxygenase beta chain, 4,5-PCD.
Protein: GDPD2_HUMAN
Sequence: MAESPGCCSVWARCLHCLYSCHWRKCPRERMQTSKCDCIWFGLLFLTFLLSLSWLYIGLVLLNDLHNFNEFLFRRWGHWMDWSLAFLLVISLLVTYASLLLVLALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFLHIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLSRTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQTVPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPDEDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKALHKDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWTFLLQRRFVKKRGKTGLETAVLLTRINNFMME
What is the function of this protein?
Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine.  Accelerates the program of osteoblast differentiation and growth.  May play a role in remodeling of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Glycerophosphoinositol inositolphosphodiesterase GDPD2, Glycerophosphodiester phosphodiesterase 3, Glycerophosphodiester phosphodiesterase domain-containing protein 2, Osteoblast differentiation promoting factor.
What is the protein family that this protein belongs to?
Belongs to the glycerophosphoryl diester phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with the actin cytoskeleton.
Protein: RL22_COXBR
Sequence: MEVAAKLKYARISAQKARLVADQVRGLGAEQAVNLLRFSNKKAAALMKKVLDSAIANAEHNEGADIDELKVSTVMVDEGPSARRFHARARGRANQILKRTCHITVKVSDSQVEND
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y2109_PHOLL
Sequence: MAGHSKWANTKHRKAAQDAKRGKIFTKIIRELVTAARLGGGDPASNPRLRAAIDKALSNNMTRDTLNRAIARGVGSDEADNMETIIYEGYGPGGTAVMVECLSDNRNRTVSDVRHAFTKTGGNLGTDGSVAYLFAKKGVISYAPGLDEDAVMEAALEAGADDVETYDDGAIDVYTTPETFGDVKDALDAAGFVAESAEVSMIPSTKAELDAETAPKLLRLIDMLEDSDDVQEVYHNGEISDEIAALL
What are the official names of this protein?
Probable transcriptional regulatory protein plu2109.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT114_LACTA
Sequence: MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKLFKKRPKNCDQ
What is the function of this protein?
Insecticidal, cytolytic and antimicrobial peptide.  Forms voltage-dependent, ion-permeable channels in membranes.  At high concentration causes cell membrane lysis (By similarity).
What are the official names of this protein?
M-zodatoxin-Lt8o, M-ZDTX-Lt8o, Cytoinsectotoxin 1-14.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 06 (cytoinsectotoxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS27_METAC
Sequence: MVDYTQRPKSRFLRVKCNDCENEQIIFGSASRKITCVVCGRTLAEPTGGKSTITTHILEVLE
What are the official names of this protein?
30S ribosomal protein S27e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: ZIPA_GLAP5
Sequence: METHILFFILAGLLIAVLIGYSIWSARREKSRIFSNTFSTRPPSSPISNEITADIPTTLNPQGVVAQQPFNTETPADFIQSQQEVENSVKNIRISLQTQEISQPLYQETMPESPSEAYQQNQIQEQTVQVEQVETIEQTTEHNIITLYVVAPEGVQFQGNAIVQNLEMLGFHFGEYQIFHRHLDNPASPVLFSVANMMQPGVFDLARMEQFSTVGLVFFMHLPSVGNDLANLKLMIRTVESFAQSVGGFVLDEQHQIFNDESRQNYLLRVAN
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.