PharMolix/UniProtQA huggingface dataset:
Protein: BIOB_HALHL
Sequence: MTETDTWHWDQPQIHALFELPLPELLFRAQEVHRRHFNPGQVQACTLVSIKTGACAEDCTYCSQSARYDTGLEREALIDVETVREAAQRARASGATRLCMGAAWRGPKDRDLETLVAMVRAVKAEGLEACLSAGLLAEGQAERLAEAGLDYFNHNLDTSPSYYDQVVTTRSYEQRLQTLERIRDAGMRVCCGGIVGLGEARADRVEMLATLANLPVPPQSVPINRLIPIPGTPLEAAEPVDPFEIVRTIAATRLVLPRSYVRLAAGREQMSDELQALCLSAGANSLFLGERLLTTDNPDADADHRLLHRLGMTLEPRTHSCAELEP
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RS20_SHEB9
Sequence: MANSKSAKKRALQSEKRRQHNASRRSMLRTYVKKVIAAIKAGDHKTAAEAFAVAQPIVDRMATKGLIHKNKAARQKARLNAKIKAIAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YPFH_ECOLI
Sequence: MKHDHFVVQSPDKPAQQLLLLFHGVGDNPVAMGEIGNWFAPLFPDALVVSVGGAEPSGNPAGRQWFSVQGITEDNRQARVDAIMPTFIETVRYWQKQSGVGANATALIGFSQGAIMVLESIKAEPGLASRVIAFNGRYASLPETASTATTIHLIHGGEDPVIDLAHAVAAQEALISAGGDVTLDIVEDLGHAIDNRSMQFALDHLRYTIPKHYFDEALSGGKPGDDDVIEMM
What is the function of this protein?
Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.
What are the official names of this protein?
Esterase YpfH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Protein: LCMT1_CANGA
Sequence: MELAVQRTDTDALSSKVSAIHTKYLSGGISQQFAYEEVYGEYLASLRQVSRRVFGKCRYSGASFPVMNYGTYLRTVAIDERVLEFLQCNSGSQVQIVNIGCGSDLRMVSVLAKHSNVKYIDLDFKESVELKRQVLEKSSTLSSYLKNDNYVLRSCDLRDVPDTLELLNEECKPELPTLIISECVLCYMPEKETQSLIDGIIRLFKNGSWVSYDPMGGSDKNDRFGVIMQQNLRDSRQLEMPTLLINNSPEIYASRWTPNSDEQFERVVTDMWTYYNDKVPAEEKQRIKRLQFLDELEELKVMQSHYVIFFCKWNANPN
What is the function of this protein?
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
What are the official names of this protein?
Leucine carboxyl methyltransferase 1, Protein phosphatase methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: SYT_BURP0
Sequence: MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIVTDKDADGLDIIRHSTAHLLAYAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAIEKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEIIESIPASDEIKLYSHGSFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEKRDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFNKLAMSVYEDFGFDRIDIKLSLRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCGTLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAHAVVLNIAESQAEYARTVAQSLQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKEREAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STS18_POSPM
Sequence: MPSAIPMLYLPDTMSAWPWQRAINPYFNEVKAASNSWFKSFRAFSPASQKAFDKCDFCLLAALAYPRARKEHLRTGCDLMNLFFVIDEYTDVEDANVCRDMVDIVIDALRRPHDPRPEGEVVLGEIARQFWARAIETASPTSQRRFLETFIAYLESVVLQAADRDCDAEHTVQTYLAQRRDNIGSYPSYAVLELALDIPDDVFYHPAMNELSLYATEMLIIDNDLVSYNREQASGDTNNILFVIMRQFNCSLDHAMAWAAAYHSQLEARFMDAFKRMPSWGLEIDSQVEEYCQGIANWPRGNDCWSFESGRYFGDKGREVQKTRCVPLLPKKERDTSLRQQDVVITSL
What is the function of this protein?
Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to delta(6)-protoilludene.
What are the official names of this protein?
Delta(6)-protoilludene synthase 18, Terpene cyclase 18.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: ATBP_DROPE
Sequence: MGFPRILSKNNKIYTKLGEFCLSGDSFWIVCHTCQEELQTQDQFWKHIQDEHNFLHGVAKEHSRTSSYCLTDVEAAAATSGATTSQGAGSVTSVTVPLALYHCSTKYSEDDQREMDIHEAQQQQHQQQHQQQQQLQQQQQRDVAKELAELHANAVAVASAAAAAANESSTRSSSGIDIKIEPPCLTLPPEMQAAAAASNATIYHLPQLGPAAVPPPPPTTGFVSANVSTSTTVSTTPPNVTGSHSVMQQQAGVLTGSGLSTLSMSVGPSTAMAAALLSTQELPKDSNSTTASAGSAVSSDDGERWYICDYETCGLKFKYKSRMELHRVVHSKERRFNCELCSASFKQSCNLSTHRKKKHALRGIKSEILPQRF
What is the function of this protein?
May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions.  Binds to AT rich DNA (By similarity).
What are the official names of this protein?
AT-rich binding protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: FB248_ARATH
Sequence: MGKVSPKDLDSKTSVRKKKLKSSSNKYLKPGALVQLCYSKASAAKSCNELGKKRVPVFDTKSCNDLGKKRVPVFDIKHARNNKMAVEQLNSPKSPLMLSPVNVVKRSTLVRPMKFDDLQVESNNTCKKSPLMLSPMGIVMQNTLLRTPKTPQADPCVSESQLESLPMDLLVKIVCHLHHDQLKAVFHVSQRIRMATILARQYHFNYTTPDRSRQEMLRVMTPVPINRWPFRRGDGNPTMVSSPHTPKAPKHAPRPPSRTKLAEMKQITAVLFQDQTPFPSRCIVPSVLQRPTLFKPMAPKHPRVLFYEDELCQAVAQNNLT
What are the official names of this protein?
F-box protein At4g35930.
Protein: Y4111_BACC2
Sequence: MLYLHDVWVNWFEGEENGYNVCHFYEWRKDDTIELLDQVPLLKVDATLYHYIEDELLELPQKLLEDVHHKAYIRKNHERLQQEYCFVVTDGKGIIAIDTIGYNVPIRKSRLIPRQEQMVYEMVENVQAEKYEFQVEETEKEHHILSPSPFIMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWYTEWDPSAYGTVQHMEFEDIWARLYDEAESGWSEKHEQLCERLVKGQPFFEKLWEMENEQKVN
What are the official names of this protein?
UPF0736 protein BCG9842_B4111.
What is the protein family that this protein belongs to?
Belongs to the UPF0736 family.
Protein: RL31_NOCSJ
Sequence: MKKDIHPAYVETQVTCTCGATFTTRSTATSGTIHADVCSQCHPFYTGKQKILDTGGRVARFEARYAKKAAADAKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PMT1_TOBAC
Sequence: MEVISTNTNGSTIFKNGAIPMNGHQNGTSEHLNGYQNGTSKHQNGHQNGTFEHRNGHQNGTSEQQNGTISHDNGNELLGSSDSIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPSIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPVNPIDKETTQVKSKLGPLKFYNSDIHKAAFILPSFARSMIES
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (PubMed:8038607, PubMed:31276744, PubMed:34095742).  Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (PubMed:8038607, PubMed:9620262).  Promotes leaves ripening (PubMed:34095742).
What are the official names of this protein?
Putrescine N-methyltransferase 1, NtPMT1a, A411.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Putrescine methyltransferase family.
Protein: DCD_XANCB
Sequence: MSIKSDRWIKRMAEQHAMIEPFEPGQIKHDAAGQRIVSFGTSSYGYDVRCSREFKIFTNINSTIVDPKHFDPGSFVDIESDVCIIPPNSFALARTVEYFRIPRDTLVVCLGKSTYARCGIIVNVTPLEPEWEGRVTLEFSNTTPLPARIYANEGVAQMLFFQSDEVCETSYKDRGGKYQGQTGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: METE_BUCAP
Sequence: MTIFNHTLGFPRIGLNRELKKAQEDYWSGNLLYEDFLCVGSQLRRENWKKQKDAGIDYIPVGDFAWYDHVLSTSMMLGNIPERHLNVNDNKIDLDCLFRIARGCSPDVAASEMTKWFNTNYHYIVPEFNKNRILKFSWKQILEETDEALLLGYKVKPIILGPITYLWLGKIKGEYFDRLDLLKNILPIYKQVLRELSQRNIDFVQIDEPALVLDLPEKWKKAYSYAYEYLNGTTKILLTTYFDSIEHNIEYIRDLPIYGIHIDLVFGKYNLFDFNSKLPKEWILSLGVINGRNVWRADLIKLFKSISTILKFRKKLLIGSSCSLLHSPIDLQKEKNLDKESKKWFSFAVQKCTELSLLSKALNKNDTDSIQKWCSSIYERNFSKRVQKIEVQNRLSEILNVNFKRSDSYNIRSREQKKKFNLPILPTTTIGSFPQTLQIRKLRRDYKQGLINDVDYEIGIKKHIKEVIKEQEKLGIDVLVHGEPERNDMVEYFGENLDGFIFTDNGWVQSYGSRCVKPPIIIGDVSRLKPITVKWSKYAQSLTDKPVKAMLTGPVTILFWSFPREDISLEKIAKQIGLALRDEVLDLEKEKIEIIQIDEPALREGLPLRKSLWNEYLSWAVDAFRLSSSGVKNTTQIHTHMCYCEFHDIMHAISFLDADVITIETARSDMELLKSFKTFKYPNEIGPGVYDIHSSNIPSITSIKFLLNKAIAYIPVERIWVNPDCGLKTRNWNETILALKNMVCAAKEMRDKIKKIT
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: ILVC_ALKEH
Sequence: MQVYYDKDADLSIIQGKKVAVIGYGSQGHAHANNLKESGVDVVVGLREGSSSAAKAQKAGLAVASIEDAAAQADVVMILAPDEHQAVIYHNQIAPNVKPGAAIAFAHGFNIHFGQIQPAADLDVIMVAPKGPGHLVRSTYVEGGGVPSLIAIHQDATGKAKDIALSYASANGGGRAGVIETSFREETETDLFGEQAVLCGGITSLIQAGFETLVEAGYAPEMAYFECLHETKLIVDLLYQGGIANMRYSISNTAEYGDFTRGPRVINEESREAMREILAEIQEGEFAREFVLENQAGCPTLTARRRLAAEHEIEVVGERLRGMMPWINANKLVDKDKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GHRA_ECOUT
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLKPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERLCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC6_DICDI
Sequence: MSKRKLGHDGNSHELDEEEEEEEEDDDDELIHSTQDQDRPHKQQRVENGKQMTPTKQHQQQQQQQPISNGRLKKLKAQSSDEESGSSEDDDEDVEDVDSSGSDSGSSDDDDDDDDDDDDDDGNSEDEREAVRREQQLKSGVTEPEAGIIESITLENFMCHRHFKLDFCSNVNFIAGENGSGKSAVLIALIVCLGAKAGFTNRGSKLSDLVKAETNTAVITVKLRNQGQEAFKPEKYGKSVIIERRISRTGSSGYKVKDYNGKTVSDKFNDVSLILEQFNIQIDNPMSILTQDTSRQFLNSAGPQDKYKSFLMATQLDKMTKDYTTIREHIDKIKDMLSQKVVVIQELEKKVREYNKEYKDLQQMVGLERKISEFKNQLAWSFVVESEREAKRKEKQVAEAEERSFDNDIRKVDETIETYNKSIEDIKKDIKEFTDQIKIQEQKKETNNREILTIEREEAKIQTQIEANNKKRQQRKQRRHLQLQSINEIKERNAQLANNQSKLDEIKKKGQQKLQLEARKEELIKEKEDLMRDRENLKRDHQNQRTITQQMNREYEGLRVQLNNLRSTQKGENQAYGKGMTDFLHKIEASRRNFSKLPIGPIGLSLKIKNESWAFAIESAISKATLRNFLVFSIPDGITLQKLGHQFGIKVDYTKIPETTEVYKTVEHDELDPSLATVLRVLDSPSHFIINFLIDTKKVEQIGLGNDRKEIDSVLYTDRCPRGLSQFFDPQGNNYSKTKSGNPFYQAAKNSGEATMLRVNSDAAIQRTQRDMESKLPALNQQKKIEQELSSDVQAIEHKISQNDQDQNQCSRKILQITNEIKSIEDTLVQQTDDYSELEIGLASLDEEIKSMDEEINIQKAQRTEVAAQKGPFAENNRALDDQIDVLSNQLGNIENNLRKFNEGLRKLNNNKQALLQQQGRSAQERDQFKAEYQRILEIVKEKTDKATQICERIEIPTNETNTTLTNKIIQYTKQLEKESRGKRSRTEALKLFQDANNSLKEISEQRDNIEELATILERNLNERYKKWQRFRLSISRRSDQYFNIFLSKKGYTGSLTFDHQNGKLDINVELQKALPSNQNGTAKGDTKGLSGGERSFSTVSLLLAFWENMECPFRAMDEFDVFMDEVNRSISINLLMSKAEENRSKQYIFVTPLALNHIKTSEYVKVFRVRAPVRTGGDVTVETD
What is the function of this protein?
Core component of the smc5-smc6 complex, a complex involved in DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the smc1-smc3 cohesin complex to double-strand breaks (By similarity).
What are the official names of this protein?
Structural maintenance of chromosomes protein 6, SMC protein 6, SMC-6.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC6 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin.
Protein: TOP2B_HUMAN
Sequence: MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
What is the function of this protein?
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.  Plays a role in B-cell differentiation.
What are the official names of this protein?
DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
Protein: ANMK_NEIG2
Sequence: MAFCTSLGVMMETQLYIGIMSGTSMDGADAVLVRMDGGKWLGAEGHAFTPYPDRLRRKLLDLQDTGTDELHRSRMLSQELSRLYAQTAAELLCSQNLAPCDITALGCHGQTVRHAPEHGYSIQLADLPLLAELTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRVVLNIGGIANISVLPPGAPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLGRLLAHPYFSQPHPKSTGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPVLMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCILGAGYYY
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PNCB_BART1
Sequence: MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPTVNVTFSLINRTKTIRLADDIDESELRAQLDHALSLRFTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELARKDGQYILHFHGSWAHSSMWEIPALAIISELRSRAALKKLDRFALDVLYARAKAKMWRKVERLKKLPDIKISDFGTRRRHSFLWQRWCVEALKEGIGDSFTGTSNVLLAMDTDLEALGTNAHELPMVIAALSNNDDELRRAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLCDAPDWVADWTGFRPDSAPPIEGGERIIQWWKEKGQDPREKLLIFSDALDVDTIEKTYHHFHGKVRMSFGWGTDLTNDFTGCAPQEIATLDALSLVCKVTHANGRPAVKLSDNPEKTIGDSKEVQRYLNFFGNKKRVARPVKM
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: XYLP_LACPE
Sequence: MSVSMQHHSSEASPATQPASVIHKNMVPWSERFSYSLSDFACNLSFSLVSTYLMFFYTDVFGISAAIVGTLFLVARIVDAFDGPFWGIMIDHTHTRWGKSRPYWLWFAIPFAVFSVLCFTVPNMSTGMKVVWAYVTYIGVDVLYSAVNIPITSILPSLTSNPQERVTLSTIRQFMGTLGATIISTIALPLVAYFGGGSTSSAHGWFMVALIMAVIAMVIFFIVFANTKERVQTVQSKKSIPIKTSLKALKRNWPWVIVIFINFIYWLGMQTRSQVTVYFFKYNMHDATLASFILGLQLVALLAVVITPWTAKRIGKRNTMLMGMLLAIVGQLILWGGSKALNVPTITVGTIVGYLGTGFVSGLIAVMLADSVDYGEWKNGVRAEGIVTSFSSFSAKFGMGIGGAVTGLILSAGGYVANHAQSAQALNAIEMNYVWVPIVGFGLSAIALLFYKVDKIEPKMLADLEQKHAQENALADDQK
What is the function of this protein?
Involved in the metabolism of isoprimeverose (PubMed:9573180, PubMed:9683504).  Transports isoprimeverose into the cell.  Transport is driven by the proton motive force generated by malolactic fermentation.  Cannot transport D-xylose (PubMed:9683504).
What are the official names of this protein?
Isoprimeverose transporter, Isoprimeverose cation symporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADK_HAEIN
Sequence: MNHLYRSFKTIALVGKPRNDINLQMHKNLFHWLMERGYQVLVEKEVAITLELPFEHLATLEEIGHRAQLAIVIGGDGNMLGRARVLAKYDIPLIGINRGNLGFLTDIDPKNAYSQLEACLERGEFFVEERFLLEAKIERASEIVSTSNAVNEAVIHPAKIAHMIDFHVYINDKFAFSQRSDGLIVSTPTGSTAYSLSAGGPILTPNLNAIALVPMFPHTLTSRPLVVDGDSKISIRFAEHNTSQLEVGCDSQITLPFTPDDVVHIQKSEHKLRLLHLKIIIITMC
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_STRZJ
Sequence: MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKPKKVWASARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RIBA_SHESW
Sequence: MSIKYVATSKLPTPWGVFAMHGFEDTETGKEHVALTFGTLSADEPVLGRIHSECLTGDALFSLRCDCGFQLQTAMQNIAETGCGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFPADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKEFGIEVVERVPLQVGKNRYNEAYLKTKSTELGHMMSEYHFVDED
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: LYPD1_HUMAN
Sequence: MWVLGIAATFCGLFLLPGFALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASALRPGLRTTILFLKLALFSAHC
What is the function of this protein?
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.  In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs.  May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface.  May be involved in the control of anxiety.
What are the official names of this protein?
Ly6/PLAUR domain-containing protein 1, Putative HeLa tumor suppressor, PHTS.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: SYY_ECOHS
Sequence: MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_MANSM
Sequence: MSSYLFTSESVSEGHPDKIADQISDAVLDEILKQDPKARVACETYVKTGMALVGGEITTSAWVDIEYIARQVICDIGYTSSEMGFDGHSCAVLNGIGKQSSDINQGVDRDDPLNQGAGDQGIMFGYATNETEVLMPAAITYAHRLMERQAWVRKNGTLPWLRPDAKSQVTLKYENNKIVGVDAVVLSTQHSDSVTQEDLHEAVMEEIIKPVLPAKWLSKDTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQLSYAIGVAEPTSIMVETFGTGKVADELLVALVREHFDLRPYGLIKMLDLIKPIYRETAAYGHFGREQFPWEKTDRAAELKAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_SALCH
Sequence: MKKLKINYLFIGILTLLLAAALWPSIPWFGKTENHIAAIQARGVLRVSTIDSPLTYSVINGKKYGLDYELAQQFANYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYDSARVKNYQPGPMYYSVSQQLVYRVGQYRPRSLATVNENQLTIAPGHVVVNDLQRLKETKFPDLSWKVDDKKGSTTLLEEVISGKLDYTIADSVAISLFQRVHPELAVALDVTDEQPVTWFSRLDDDNTLSAALLDFFNSINEDGSLARIEEKYLGHGDDFDYVDTRSFLRAVDNVLPELEPLFKKYAKEIDWRLLAAISYQESHWDPLATSSTGVRGLMMLTKNTAQSLGLTDRTDAEQSISGGARYLEDMMAKVPETVPEDERIWFALAAYNMGYAHMLDARSLTVKTKGNPDSWTDVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQEAEAMKLAQDYPAVSPEELNKTPFPLLSFLSQSSGYLTHSPSLLFTPQKKEEK
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.