PharMolix/UniProtQA huggingface dataset:
Protein: TXI92_DIGCA
Sequence: MKVFVVLLCLSLAAVYALEERLDKDADIMLDSPADMERAKDGDVEGPAGCKKYDVECDSGECCQKQYLWYKWRPLDCRCLKSGFFSSKCVCRDV
What is the function of this protein?
Insecticidal toxin (PubMed:8541888, PubMed:8896202).  This toxin promotes opening of insect Nav channels.  The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i. e. , receptor site 4).  The American cockroach P. americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop.  In vivo, paralyzes lepidopteran and dipteran larvae.  Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760).
What are the official names of this protein?
Beta-diguetoxin-Dc1a, Beta-DGTX-Dc1a, Dc1a, Insecticidal toxin DTX9.2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 26 (DTX) family.
What are the subcellular locations of this protein?
Secreted.
Protein: OSPF_SHIFL
Sequence: MPIKKPCLKLNLDSLNVVRSEIPQMLSANERLKNNFNILYNQIRQYPAYYFKVASNVPTYSDICQSFSVMYQGFQIVNHSGDVFIHACRENPQSKGDFVGDKFHISIAREQVPLAFQILSGLLFSEDSPIDKWKITDMNRVSQQSRVGIGAQFTLYVKSDQECSQYSALLLHKIRQFIMCLESNLLRSKIAPGEYPASDVRPEDWKYVSYRNELRSDRDGSERQEQMLREEPFYRLMIE
What is the function of this protein?
Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3.  This epigenetic modification results in inhibition of the transcription of a specific subset of pro-inflammatory genes, and ultimately to a reduced immune response against the invading pathogen.  The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host.
What are the official names of this protein?
Phosphothreonine lyase OspF, Effector protein OspF.
What is the protein family that this protein belongs to?
Belongs to the phosphothreonine lyase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cell.
Protein: CPGS_METFV
Sequence: MGETKKMICLVDGEHYFPVVKDSIEILDDLEHIDVVAVVFIGGTEKLQIEDPKEYSEKLGKPVFFGPDPKKIPYDVIKKCVKKYNADIVMDLSDEPVVDYTKRFRIASIVLKEGAVYQGADFKFEPLTEYDVLEKPSIKIIGTGKRIGKTAVSAYAARVIHKHKYNPCVVAMGRGGPREPEIVEGNKIEITAEYLLEQADKGVHAASDHWEDALMSRILTVGCRRCGGGMLGDTFITNVKRGAEIANKLDSDFVIMEGSGAAIPPVKTNRQIVTVGANQPMININNFFGPFRIGLADLVIITMCEEPMATTEKIKKVEKFIKEINPSANVIPTVFRPKPVGNVEGKKVLFATTAPKVVVGKLVNYLESKYGCDVVGVTPHLSNRPLLRRDLKKYINKADLMLTELKAAAVDVATRVAIEAGLDVVYCDNIPVVIDESYGNIDDAIIEVVEMAIDDFKNNR
What is the function of this protein?
Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.  It is also able to catalyze the hydrolysis of cDPG but with significant slower rates (8-10 times).  May be involved in thermoadaptation.
What are the official names of this protein?
Cyclic 2,3-diphosphoglycerate synthetase, cDPGS.
What is the protein family that this protein belongs to?
Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_CHLTE
Sequence: MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYRGMAAYASFLGVKPELVIMSNGSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAGVVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSKSLSHDEIERIVEAADAIVLVDEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPFASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVANASEVFRKLKNAGVLVRNVSGYPLMENCLRFNVGLREENDRLLELLKKL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: YR508_MIMIV
Sequence: MSKRVTSSKKSKIMREDSENDSAKNLSKTSKSVSKSKEAGSKRTKQNSSKSSKDLKTTKNIGGSKSSRTYNSEGSKNIKKTSSSKDSKVIKKNKQKVESSDSEKHSENKSHKKSSKSSSISRKKPIKKDTRKINIELVSDSDNNSDSELNGVDTTGDDIIYLKGEDNNDEKQNKKSPKKLLNEKKISSESFDDKLNELREELRENYIRQKKIMNDIKDLANLHKKDLRLAVKSGNRLNSGKHSGFNKPQTVPQSLKDLLKINDDVLSRSKVTELMYKYFTDNKMYNSKTKREIIPNSKIKKLFGMKEGDIITFYNMQTWLKKVYNENQNNEKLEE
What are the official names of this protein?
Putative SWIB domain-containing protein R508.
Protein: UVRC_CHRVO
Sequence: MSKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLMVRQIASIETTVTRSEAEALILENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYRGEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVFANRSRPCLLYQIKRCSGPCVDHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQEKQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEAFIGQHYQHAGVPAALVVNGVVDDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAELAILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTMGEATVASCVVYDKGAMQPTEYRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELGLNLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRARRAKARTSSTLEDIPGIGAKRRQQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNALH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_KOCRD
Sequence: MFKNPAELADRVLAGTPVTPDEALDLLRTDDPGMLDLVAAAARLRREHFGMTVKVNYLVNLKSGLCAEDCGYCSQRLNAGTDILKYSWLSPEQAVEQAEYGIKGGASRVCLVASGRGPSNREVGNVTRTVEALKEQHPDVEVCACLGLLKDGQAESLSSAGVNAYNHNLNTAESHYESICSTHTYQDRVDTVERAKDAGLSPCSGLIVGMRETDEQLVEAVFALRDLGSDSVPVNFLMPFEGTPLAGTWQLSPQKCLKILAVVRFVCPDKEIRMAGGREMHLRSLQPLALHVVNSLFLGDYLTSEGQAAEADLAMIADAGFTVLGAGPDPSRDRHAGPADVQGSGAEQGAGERTTTPCGSVCGSAAGSSSGDGSAPDGGRAPADVSRSGPAEAVGSSPEDGSRNAGGPARTRSAAASSAPTGAGMSPALAALLGSDDGPEQDEDDTRVRVELSPTVRRRGAGTSVAPNA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RL21_DEIRA
Sequence: MFAIIQTGGKQYRVSEGDVIRVESLQGEAGDKVELKALFVGGEQTVFGEDAGKYTVQAEVVEHGRGKKIYIRKYKSGVQYRRRTGHRQNFTAIKILGIQG
What is the function of this protein?
Binds directly to 23S rRNA, probably serving to organize its structure.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: YBAB_SHIBS
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RECO_MANSM
Sequence: MLHRKPYSETSLLVDLFTEESGRLTVLAKGARAKRSALKSVLQPFTPLLLRWTGKSSLKILTKAEPAAIALPLQQTALFSGFYVNELITRVIEPETPNPQLFQDYLHCLTSLAVSQNFVEPALREFEFKLLNILGYGVDFLHCAGSGEPVDENMTYRYREEKGFIASLIKDNLTFFGRELIAFERQDFSEKSVLQAAKRFTRVALKPYLGNKPLKSRELFTQTILHLK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SAA2_HUMAN
Sequence: MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY
What is the function of this protein?
Major acute phase reactant.
What are the official names of this protein?
Serum amyloid A-2 protein, SAA2.
What is the protein family that this protein belongs to?
Belongs to the SAA family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF1_AYWBP
Sequence: MSKNNLNETESKIEIEAKVVELLSNDKFKVELPNKKTIIAYVSGKIRINNIRILPGDKVRIELSPYYPTQARITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_STRSY
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTIISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEEYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDHMVAEFKKENGIDLSADKMALQRLKDAAEKAKKDLSGVTSTQISLPFITAGAAGPLHLEMTLTRAKFDELTYDLVERTKIPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNDVDQAIFATEKTLKETEGKGFDAERDQAQAALDELKAAQEANNLDDMKAKLENLNEKAQALAVKLYEQAAAAQQAAAGQEGAQTANNADDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MNMA_ERYLH
Sequence: MNAVAPLPLPADAADMFDLPRPAAESRIVVAMSGGVDSSVVAALAHASGAEVIGITLQLYDYGAATGRKGACCAGDDIQDARAVADRLGIAHYVFDHESAFREDVVEQFADDYLSGRTPVPCIRCNMGPKFTDLLRMARELGADCLATGHYVRRVAGEHGPELHRALDPARDQSYFLYGTTETQLDFLRFPLGDLPKTAVRELAEAAGLRNAAKPDSQDICFVPDGDYAKIVKTMRPEGGTPGDIVHAQTGEVLGQHKGIVHYTVGQRRGLEIGGQPEPLYVVGLDAAASRVKVGPKRLLAVQAASVIETNRIGPLPDVPLTAKVRSLAKPVPITLDGSLGDGATTRITFEQPEFGVAPGQAGVIYAGDRVIGGGWIDSTESAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRD_ALIFM
Sequence: MASAKDIKKSILAPVLDNNPIALQVLGVCSALAVTTKLETAFVMTLAVMFVTALSNLFVSLIRNHMPNSVRIIVQMAIIASLVIVVDQVLKAYLYDISKQLSVFVSLIITNCIVMGRAEAFAMKSAPFPSFIDGIGNGLGYGFVLMTVAFFRELLGSGKLFGVEVLPLVSNGGWYQPNGLMLLAPSAFFLIGFMIWAIRILKPEQVEAKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCD_SYNPW
Sequence: MSLFDWFADRRKEQSVVKVAQEPEEGDGLWSKCPECGQVVYRKDLLANASVCSNCGHHHRINSAERIALIADEGSFEAMDEALAPTDPLGFKDRRAYADRLRETQSGTGLRDGVITGMCRVDGIPMALAVMDFRFMGGSMGSVVGEKLTRLVEQATAKRLPLLIVCASGGARMQEGMLSLMQMAKISGALERHRQAGVLYMPLLTHPTTGGVTASFAMLGDLILAEPKALIGFAGRRVIEQTLREKLPDNFQTAEYLQDHGFVDTIVPRTQLKSTLANLMKLHGCLQGSAAV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZMYM5_MOUSE
Sequence: MEAHLADMESSGGPTSSLAGTSRNTHVEDDDVVFIESVQPPICAPAIPNERNFVFASSKHENPPGTDSTISPSWRDLTSQKGNLCETIVIDDEGDTDTNGGEEKNPTDFIEWGPNGNKSSTKNVDFPIASLSRSKTKTAVGPFNPGRIDVTDAFQNGRFAVHHNPDSWISQSASFPRNQKQQGVDSLSPVASLPKQIFQPSNQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTRKTRNVMCKKDSPVRTTTIVPPVESSKSLQGFYNASLSPYENCQSLRKEVFTKSRCIICNKLGEVRHEISVNSITHKLCSNNCFNEYRLTNGLIMNCCEQCSKYMPKSTGHSILITGQQKRFCCQNCADEYKEIMEAKSKLLLLQNRKRNAIREENEKRLRESSGTLSGNTGDIPEKKEKSSEIIKVAADCSLDTSSEEQNVNLPCSVAVISDTFKEQLGDKNSEELDMSILPSLDPGSWPRILNMKQREFLVKNNPPQIRNFNFPKDSAGKKFSETYYTRILPNGEKGTRPWLLYSASKDSVFCLYCRLFGEGKNQLRNENGCKDWHHLSHLLSKHDESEMHINNSVKYSKLKSDLENKTNEATEGGEDCVQLLYT
What is the function of this protein?
Functions as a transcriptional regulator.
What are the official names of this protein?
Zinc finger MYM-type protein 5.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAST_CHACK
Sequence: INWKAILGKIGKAAAAVI
What is the function of this protein?
Is able to induce edema but does not present hemolytic or hyperalgesic activity.
What are the official names of this protein?
Communis-AAAA.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
[Communis-AAAA]: Secreted. Target cell membrane. Note=Forms an alpha-helice. SUBCELLULAR LOCATION: [Communis]: Secreted. Target cell membrane. Note=Forms an alpha-helice, which probably inserts into the membrane.
Protein: RSMA_SHISS
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_NEIMA
Sequence: MSDDKSKALAAALAQIEKSFGKGAIMKMDGSQQEENLEVISTGSLGLDLALGVGGLPRGRIVEIFGPESSGKTTLCLEAVAQCQKNGGVCAFVDAEHAFDPVYARKLGVKVEELYLSQPDTGEQALEICDTLVRSGGIDMVVVDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKLTGHIKKTNTLVVFINQIRMKIGVMFGSPETTTGGNALKFYSSVRLDIRRTGSIKKGEEVLGNETRVKVIKNKVAPPFRQAEFDILYGEGISWEGELIDIGVKNDIINKSGAWYSYNGAKIGQGKDNVRVWLKENPEVADEIDAKIRALNGVEMHITEGTQDETDGERPEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUE_ECO24
Sequence: MFAEYGVLNYWTYLVGAIFIVLVPGPNTLFVLKNSVSSGMKGGYLAACGVFIGDAVLMFLAWAGVATLIKTTPILFNIVRYLGAFYLLYLGSKILYATLKGKNNEAKSDEPQYGAIFKRALILSLTNPKAILFYVSFFVQFIDVNAPHTGISFFILATTLELVSFCYLSFLIISGAFVTQYIRTKKKLAKVGNSLIGLMFVGFAARLATLQS
What is the function of this protein?
Exporter of leucine.
What are the official names of this protein?
Leucine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NNRD_CRYNJ
Sequence: MASKQHAHILSLARSMIPPLHPKLHKGQAGRIGVLGGSGDYSGAPYFSSMGAMRFGADLAHVICEPSAGAVIKTYSPDLIVHTILDPQKSREDIRSALKGVMSRLHVLIIGPGLGRDDHMQSCAKIAFELAKDMEQMGVVVDADGLWLVQNEPKVVMDWPGVPRIILTPNVMEFKRLCDTMVGARTVLHLSPSTLINYQKINASGPHTSLCPQLATALGNATIIQKGPSDIISNGLKIPSALLSDESEEQNYLEVKVEGGLKRVGGQGDILSGSTGVLLAWGSEWVRGTYEHVGHPPPQDKAIAENIPVLAAYGASTFNRTVSKRGFQKKGRSMVTGDLVDMVGEVYEEVFGKPGEMEGRGKL
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_SHEPA
Sequence: MSIENSAVSDHSGVNKVVLAYSGGLDTSAIIPWLKETYDNCEIVAFCADVGQGDAELEGLYEKAIASGASECYIVDLKEELVADYIYPTIATGAIYEGTYLLGTSMARPIIAKAQVEVARKVGADAVCHGCTGKGNDQVRFEGCFAALAPDLKVIAPWREWEMVSREDLLDYLAERNIATAASATKIYSRDANAWHISHEGGELEDPWNEPSKGVWTMTVAPEDAPNQPEYVSLELEQGKITKVNGEALSPYKALMVLNEVAGAHGVGRIDITENRLVGMKSRGCYETPGGTVMFAALRAIEELVLDKTSREWREQVGAQMAHLVYDGRWFTPLCESLLGASKPLADLVNGEVVVKLYKGQASVVKKRSPNSLYSEEFATFGADDVYNQKDAEGFIRLYSLSSRIRALHSQK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRA_SHIFL
Sequence: MQTSNITNHERNDSSWMSTVKSTTEVSWNKLSFCDILLKIITFGIYSPHETLAEKHSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFHVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV
What is the function of this protein?
Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading.  Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles.  The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks.  Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure.  This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell.  Is absolutely required for virulence.
What are the official names of this protein?
Cysteine protease-like VirA, Effector protein VirA.
What is the protein family that this protein belongs to?
Belongs to the protease EspG/VirA family.
What are the subcellular locations of this protein?
Secreted. Note=Translocated into the host cell via the type III secretion system (TTSS). Localizes in the cytoplasm of the infected cell.
Protein: PACC_YEAST
Sequence: MVPLEDLLNKENGTAAPQHSRESIVENGTDVSNVTKKDGLPSPNLSKRSSDCSKRPRIRCTTEAIGLNGQEDERMSPGSTSSSCLPYHSTSHLNTPPYDLLGASAVSPTTSSSSDSSSSSPLAQAHNPAGDDDDADNDGDSEDITLYCKWDNCGMIFNQPELLYNHLCHDHVGRKSHKNLQLNCHWGDCTTKTEKRDHITSHLRVHVPLKPFGCSTCSKKFKRPQDLKKHLKIHLESGGILKRKRGPKWGSKRTSKKNKSCASDAVSSCSASVPSAIAGSFKSHSTSPQILPPLPVGISQHLPSQQQQRAISLNQLCSDELSQYKPVYSPQLSARLQTILPPLYYNNGSTVSQGANSRSMNVYEDGCSNKTIANATQFFTKLSRNMTNNYILQQSGGSTESSSSSGRIPVAQTSYVQPPNAPSYQSVQGGSSISATANTATYVPVRLAKYPTGPSLTEHLPPLHSNTAGGVFNRQSQYAMPHYPSVRAAPSYSSSGCSILPPLQSKIPMLPSRRTMAGGTSLKPNWEFSLNQKSCTNDIIMSKLAIEEVDDESEIEDDFVEMLGIVNIIKDYLLCCVMEDLDDEESEDKDEENAFLQESLEKLSLQNQMGTNSVRILTKYPKILV
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes.  Required for meiosis, sporulation and invasive growth.
What are the official names of this protein?
pH-response transcription factor pacC/RIM101, Regulator of IME2 protein 1, pH-response regulator protein RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: APOC1_SAIBB
Sequence: MRLFLSLPVLVVVLLMILEGPGPAQGAPESVEASSGLDKLKEFGNNLEDKVREFFKRIKESDIPAKTRNWFSETLQKVKEKLRIES
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFA_HAEIG
Sequence: MTHYILLIIGTALINNFVLVKFLGLCPFMGVSKKIETAVGMGLATMFVLTVASLCAYLVDHYILIPLNATFLRTLVFILVIAVVVQFTEMAINKTSPTLYRLLGIFLPLITTNCAVLGVALLNVNLAHNLTESVVYGFGASLGFSLVLVLFAALRERLVAADIPATFRGSAIALITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSMF1_PONAB
Sequence: MAGLEVLFASAAPAITCTQDALVCFLHWEVVTHGYYALGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFAVGGEDLDPFGHRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPNPDHLPPPGYDDMYL
What is the function of this protein?
Plays an important role in control of proteasome function.  Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome.  Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).
What are the official names of this protein?
Proteasome inhibitor PI31 subunit.
What is the protein family that this protein belongs to?
Belongs to the proteasome inhibitor PI31 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.