PharMolix/UniProtQA huggingface dataset:
Protein: MOR2_SCHPO
Sequence: MSLNEIAHDQPVENGPLYSEKQDHTAVDYALHILFTQFVRLSEQKISFLSRYHANEGKNAEPVRFNVGEQEAILLLKKGEDNEFDRCIQALVALASSKPVAVIESLLCWRKVRVDITSSSGTPRVVNERRSSISIYILCRVLTEIAETIPSNALEESTVSCLLECVFHQLLSAKNLPVSSSYFSLANWESFAFLVGSMSRFNFVMVSDRFIEEIEHLEKSGCDSRQKETVLVHLLRAMRYLRLQLYPTTLLEESIAFLQSLTSFFMKANTALKIEYAYLMEQLLRPLISRATFEVNIPAWSRTIETIYPVVLKMCTKTKYWNVFFPFCCTLLCLSPKQFFLKHWISSLDAAFFRVKDRRLRNTGLPHLSRVVWTYSNQYKEEPSIMNSNISNILKSGFSIGKKFSVVPFATLEELDGYAQIVRVVGAHFPELVIKEILTPLSTDAFTENIGPEKLMIVVRSVYYILHDMKYKKSDSTIFEYIEFEFVDLHEVAVGTPLQQFVHNLSQKLLFLVFQLSTNTNCYLDSKNATSLLALYINALKVFPCLMGKLEQRVIDAYVKCLNCSNKIIHTVCHNSLIYFSSGLKMSKSVISCLSRKLVKGSEYLLRTYHEVIRIWISQQEAVIEKRNSVLSNKSCASSESNTPASVKQDYDDIQSWTIIEEIQSLGVLHLSSPSVGIRKFAVALLNDVKQLNTEYLMLSSDKVEVGDIYSEPTIVDVLKDCDSSILSVESHLPTAAERSRLRKFINDGTKDMLLKLATSNSGVDISIWYNVFPRFIKVCFERFPTTMALLRNTVCEKLPSITMQLLSRIESSELNFNLKSAVKNDNFPEFLLVQWKLYLIVACCTITYTSNVDYSHTDLRRTLTAVQSGNHLRGLQETIKITSAESLFSMVLPLIFTEFSPIREAVVFAIGCINVNAFPQLVRSLKPYISVLKQDHQEFIFAGLNFPSVKRRNKPDLLLRSEIAHIFAMTSHLLLHELLNEDREALSVISEFLKDLKGFLSTPNVQADEKYLKLRCYFSQLLEKVLLVQNLHPSSEVLPFSGRASCWKLLDEWTGFGPARAITKNREELMRAHIRGNNKDIRERDKLLASFEAGKQNLEYLAIKAMIALCTAKLQQELTEGVFLFDIEILLNWFTAVFGSPSKAIVGLARKGLTALLLENSSNEVLLQKVINRCFSKEISQTISNYYFLSLSEMLIQINPNNLSKPKLLPLCLVNLSTNNLSVRLKAFELLGNFHLNNFTMTALMEFKTFLESSNPALYLKPQYLFSVQLASDFTEDSFTLTSECLRYFNYGHQHRRGLVTVLLPWLQNLELKMDVENKTFDSFTAVILIDLIEVTAKFTNDLPNEIEALWTSLALSRHKSNWTVILFFLMQQCYQRKTFSFVDCTRQITIYLAKTELLSDLYSTLLSFVCPANVSNENQEVYKFSLEDLSSTYVANLEDLFPSEKNHISYSPCQLSLLLLMDILPNPSIITVTDDVATILHAAFIQFDHYSRIVQEQCQQIFQYVVRKVLAMEGRLDYDDAYFDFNVESSLITGLRGKTKKEDDLVKYHNMILKTIELLSSSYPELKQIWGEVALSWATTCPSRRLACNSFQLFRSLLPDFDARMLLEIISRLVGTISDETSYLRDYSVEILRTFNSYVLVMNSDDLLSYSQILWTAIACLTTIHEDEFIESVKIAYAYFLRVEETDSATQQIMETFPQNWVGDYQGLQILILKGFRSTNSFEITMNFFLLLMDFKDNDLVGVGYLRILSCLLVSLPAMVYTYEHSDPITFDLSVFCHKLATLASQFNDDALIELLDTYLKRKFRSIKDFLKHTVSYLYSYYFEDYELEIVSTLTMFLSNNLTWFRKSTLDVLKELFPLIDFQKPIYSEHGLGIVSPLLRLLPTGYAMEALSLLTDSVLHVSAPTDMQTLKLLMVDPKLKNSDDRLAGFFEIPDEDGWYEPNSEYAAAITKSNVHAVFYSCSTTEASVSTPEVRFHADEVSNYPRHVPTDSHGSLDENSLGELVTTLHSLDVFFAEDRDEELIQPDVAVDPKLDITSEDYDDRIATILSGSLRRQKQGLMAYETESFRDYSPNEEIDASAKLPMDMPPVRVRKSSFISKLKPHYFMDAESYYPSLKALGNSAEHRLSLDEIRGAAELKQNKNWNSMLDQSVSMINEDSVEDHETHENYYHLRTMFQGSESNESFTDTTRSRGWH
What is the function of this protein?
Required for the maintenance of cell polarity.  Has a role in localizing F-actin at the cell tips.
What are the official names of this protein?
Cell polarity protein mor2, Morphological round protein 2.
What is the protein family that this protein belongs to?
To yeast TAO3/PAG1.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Found at the cell tips and at the site of septum formation.
Protein: PROA_SYNFM
Sequence: MREEVLTMGKRARQAAHHMAKVGDVHKRKALEHMALNIEGAEAAIREANDKDIRAAVAKGLPAAKVDRLRLDAKVLEEMACGLKEVARLSDPVGEITRMWTRPNGLRVGRMRIPLGVIGIIYESRPNVTVDAAALCIKAGNAVILRGGSEAFHSNRCLADILRRSLVETGLPEDAVQLVGTTDREAVLDLLKLEECIDVMIPRGGEDLIRFVAENARMPVLKHYKGVCHVFVDDEADPDMAMRICMNAKVQRPGVCNAMETLLVHAGIAQRFLPPMAEAFRAAGVELRGCERTRRIVADCAQAVEEDWYAEYLDLILAIRVVNDMEEAIEHITRYGSQHTEAIVTGNFERAHRFLQEVQSSLVLVNASTRFNDGFQLGLGAEIGISTSRLHAFGPMGVEELTTTKFIALGNGQLRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP5M1_MACFA
Sequence: MAQRAVWLISHEPGTPLCGTVRFSRRYPTVEKRARVFNGASYVPIPEDGPFLKALLFELRLLDDDKDFVESRDSCSRINKTSIYGLLIGGEELWPVVAFLKNDIIYACVPLVEQTLSPRPPLISVSGVSQGFEFLFGIQDFLYSGQKNDSELNTKLSQLPDLLLQACPFGTLLDANLKNSLDNTNFASVTQPQKQPAWKTGTYKGKPQVSISITEKVKSMQYDKQGIADTWQVVGTVTCKCDLEGIMPNVTISLNLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQLKEEEVQLRITINLKLHESVKNNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIGQKFPKSMEISLSGTVTFGAKSHEKQPFDPICIGETAYLKLHFRILDYTLTGCYADQHSVQVFASGKPKISAYRKLISSDYYIWNSKAPAPVTYGSLLL
What is the function of this protein?
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
What are the official names of this protein?
AP-5 complex subunit mu-1, Adaptor-related protein complex 5 subunit mu-1, Mu5.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=May cycle on and off membranes.
Protein: UGTP_STAAC
Sequence: MVTQNKKILIITGSFGNGHMQVTQSIVNQLNDMNLDHLSVIEHDLFMEAHPILTSICKKWYINSFKYFRNMYKGFYYSRPDKLDKCFYKYYGLNKLINLLIKEKPDLILLTFPTPVMSVLTEQFNINIPVATVMTDYRLHKNWITPYSTRYYVATKETKQDFIDVGIDPSTVKVTGIPIDNKFETPINQKQWLIDNNLDPDKQTILMSAGAFGVSKGFDTMITDILAKSANAQVVMICGKSKELKRSLTAKFKSNENVLILGYTKHMNEWMASSQLMITKPGGITITEGFARCIPMIFLNPAPGQELENALYFEEKGFGKIADTPEEAIKIVASLTNGNEQLTNMISTMEQDKIKYATQTICRDLLDLIGHSSQPQEIYGKVPLYARFFVK
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).  In vitro, UgtP can also use cholesterol, cholesterolglucoside and the fluorescent substrate 6-(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)-amino-caproyl-sphingosine (NBD-ceramide) as sugar acceptors, but it can only use UDP-glucose as sugar donor.
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: GSH1_SALPA
Sequence: MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIQHMLTFMRDLHRYTARKLGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGVTEGEAAKEKISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEKTDCGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYARIGVEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCVLADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCETAQFPLPKVGKDLFRDLKRVAQTLDSIHGGEEYQKVCDELVACFDNPELTFSARILRSMIDEGIGGTGKAFGEAYRNLLREEPLEILQEEEFIAERDASVRRQQEIEAADTEPFAAWLAKHA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: H13_BOVIN
Sequence: MSETAPVAPAAPAPAEKTPVKKKAKKSGVAAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAATGEAKPKGKKAGAAKPKKAAGAAKKPKKSTGAATPKKAAKKTPKKVKKPAAAAGTKKVAKSPKKAKAAKPKKPTKSPAKAKAPKPKAAKPKAAKPKATKAKKAVSKKK
What is the function of this protein?
H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.  H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers.  Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
What are the official names of this protein?
Histone H1.3.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
Protein: PSAA_NEPOL
Sequence: MTISPPEREAKKVKIVVDRNPVVTSFEKWAKPGHFSRTLAKGPTTTTWIWDLHADAHDFDSHTTDLEDISPKIFSAHFGQLGVILIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGFQGIQITSGFFQLWRASGITSELQLYSTAIGGLLLAAAMFFAGWFHYHKAAPKLEWFQNVESMMNHHLGGLLGLGSLGWAGHQIHVSLPVNKLLNAGVDPKEIPLPHEFLLNRDLMAQLYPSFAKGLTPFFTLNWAEYGDFLTFRGGLNPVTGGLWLSDTAHHHVAIAVLFLVAGHMYRTNWGIGHSMKEILEAHKGPFTGEGHKGLYEILTTSWHAQLAINLALFGSLSIVVAHHMYAMPPYPYLATDYGTQLSLFTHHMWIGGFCVVGAAAHAAIFMVRDYDPTNNYNNLLDRVIRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIHKTHALAPGLTAPNALASTSPSWGGDVVAVGGKVAMMPISLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSISVVIFHFSWKMQSDVWGNVTAQGVSHITGGNFALSSNTINGWLRDFLWAQASQVIQSYGSALSAYGLIFLGAHFIWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPSIQPRALSITQGRAVGVAHYLLGGIATTWAFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: UGL_BURO1
Sequence: MKLLRYGPSGQEKPGILDAAGRIRDLSAHVPDLAGDVLSDAGLARLRAIDPATLPLVSGEPRIGACVGHVGKFIGIGLNYADHAAEAGMPVPKEPVVFGKWTSSICGPNDGIDIPKGSVKTDWEVELGVVIGAKCKDVDEARALDYVAGYCVVNDVSEREWQIERGGQWDKGKGFDTFGPIGPWLVTRDEVPDPQRLDLWLEIDGHRYQNGNTRTMVFTVAQLVAYLSTCMTLQPGDVITTGTPPGVGMGVKPSPVFLKAGQTVRLGIEGLGEQLQRTRDAQ
What are the official names of this protein?
Ureidoglycolate lyase, UGL, Ureidoglycolase, Ureidoglycolatase, Ureidoglycolate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: TYSY_STRPC
Sequence: MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMFAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1274_LATSS
Sequence: MAMDQKRLDRINELAHKAKAEGLTPEETMERQELRDAYLKDFRSSFRSQVEMLQVYDKEGKEVTPEKVKDIQREKGLRDD
What are the official names of this protein?
UPF0291 protein LCA_1274.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUS1_DICDI
Sequence: MIIRFKINEIECEVNEEKEDITILQACTANGIEIPRFCYHEKLTIAGNCRMCLVYVTNEEKLLAACGIPLDENFDDESIETEIDEILKAREGVMEFLLINHPLDCPICDQGGECDLQEQTLAYGLDTGRFYIKKRAVEIKTFGRLIKGIMTRCIHCTRCVRFLTEIAGVNELGVLGRGYNMEIGTYKKNVMIESELSGNIIDLCPVGALTSAVYAYKGRPWELKNIKGIDIFDTLLTPINYQVKGGEIFRILPRINDRINEEWITDKVRFHYESYKIIEKIRKETPSYKIQANKFIELTWKTALKMVFKVLLNKKNKVDLIIGSKINSTNLRIYKELMNRLGSKNYITENGLMFKKFNYDLRENYINSNDLYNVDKNDLVLLCGINLRVESPLLNIKLRNVNFGDDEIESVKKIGIIGNKFDWKHESEYIGATLNSMLKLFEGRLPYCQQIKKSKAPLIIVGPSLLTRISLTLQEMRAIFMKACNLKPENILIITQGANFGMALEEGLFKEKFSIGGNVLYSIDSNEVQVTNKINYVIYQGIINDKFENKIDLYLPSKHYFEDFEGDREVYMNTFGQRSEIEKLSISKGNKIKENSMIGYIQLMYLNNKEMTRKEKEQKDIKLSYREMKKEEKRKIKVNKYLTINNIIENYYMTDINIRLSKNLMITGQLRKEKKIMEAGIWKNRKCI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme.  It may form part of the active site crevice where NADH is oxidized (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 75 kDa subunit, Complex I-75kD, CI-75kD.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Matrix and cytoplasmic side of the mitochondrial inner membrane.
Protein: RS13_DEIDV
Sequence: MARVAGVDLPREKRIEIALTYIYGIGLTRSKEVLAQTGISADTRVKNLTEAEQSTLRDAIEKTFKVEGDLRSEVGQNIKRLMDIGAYRGLRHRRGLPVRGQRTKTNARTRKGPKKTVAGKKKATRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MPS1_ENCCU
Sequence: MEGIFNSKSLYEYLEEQKQAGISKTKEISLYYKATSKSVGDDEYSLRIWLDYIRLLMDGTKDVTEARETFKMIKMRFCKFYNYWEAYVRFEIEAGNGSLCKILQHSIDFVKVKEFTEKKRVLEYLECVMSYARNGEDLSVFCRGPETSFKPGAQVLSPFEARIGEQSKNKVLKKEHEESGPGHRDDGKNLLSRSGRAHLAPDECKENDNKNRAREDGASLSPSFAAKSKNCGATFGTIPIRFEKEDYSQGITMEINAALGRTSPEGSNSSPRSGAVRSRERIIIKGREIEILKQIGKGGSSKVYKVLFGSNVYALKRVELIGDEKMLSSYINEINLLYKFKGTSEIVEIIDHEVGEDYLHILLEYGETDLSKIIRKGGLSMNFIKDVWEQMLLIVKRVHIERIIHCDLKPANFLFVKGRVKLIDFGISKVIRNDTTSILSEEQCGTVNYMSPEAVTQNKSKVARSSDIWSLGCILYEMVHSNPPLHEYPNLIQKIQRLQEYSEFKYTSKNKAAVMVMKECLARDPKKRPTIDNLLNHRFLTGEMCLESLRELVEKILKIDGGDRVDPEHVDRIAEQLHSTHRQDQA
What is the function of this protein?
Involved in the regulation of the onset of mitosis.  Involved in a pathway that coordinates cell proliferation and differentiation.  Implicated in spindle pole body (SPD) duplication.  Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues (By similarity).
What are the official names of this protein?
Probable serine/threonine-protein kinase MPS1 homolog, Monopolar spindle protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: VPU_HV1YB
Sequence: MLWLGFIALGVAIIIAAIIWVLLYKEYKKIKLQEKIEQIRQKIRDRTEDRGKESDGDAEWLAILLSPDKLDNWV
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: LPXA_PSEPG
Sequence: MNSIDPRAIIDPSAKLADGVEVGPWSIVGPDVEIGEGTVIGPHVVLKGPTRIGKHNRIFQFSSIGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRAETTVGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVGDWAILSGYTLVHQYCHIGAHAFSGMGTAIGKDVPAFVTVFGSPAEARSMNFEGMRRRGFSDEVIHVLRRCYKIVYRQGLTVEDALKELAEPAAQHPEVELFRQSIVSSARGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRT4_ONCMY
Sequence: MPRRRRASRRIRRRRRPRVSRRRRGGRRRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine PTP4.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CVIF2_ARATH
Sequence: MASSLIFLLLVTLTFSASTLISAKSNTTTIIESTCKTTNYYKFCVSALKSDPRSPTADTKGLASIMVGVGMTNATSTANYIAGNLSATVKDTVLKKVLQDCSEKYALAADSLRLTIQDLDDEAYDYASMHVLAAQDYPNVCRNIFRRVKGLAYPVEIRRREASLRRICGVVSGILDRLVE
What is the function of this protein?
Inhibits fructosidases from both cell wall (cell wall invertase CWI) and vacuoles (vacuolar invertase VI).
What are the official names of this protein?
Cell wall / vacuolar inhibitor of fructosidase 2, AtC/VIF2.
What is the protein family that this protein belongs to?
Belongs to the PMEI family.
What are the subcellular locations of this protein?
Vacuole.
Protein: GSHAB_CLOPE
Sequence: MVNLDKGLLKIIKDESLEDYFIKANFGLEKENVRVTESGNLALTPHPKAFGDREKNAYIKTDFSESQLEMVTPVCNTLEEVYSFICNLNKVVSLEIMKNGEFLWPQSNPPILPREEEIPIAKLSNREDELYRENLSYKYGKKKQVISGIHYNFSFKEEFIKLLYKELKVEKDFREFKDDIYLRMARNFQKYHWLLIYLTGASPVFHESYIEEIKEEGEKLGEDSYYIKDDTSLRNSSYGYKNKKDYYVSYNSIEEYASDIKNLVKDKEIQSIKEYYNPIRLKSLGSEDMLESLLHKGIDYLEVRLLDLDPLSIQGVSKETLYLLHLFMIYTLLKENKEITYKDQEEFFKNHDMVALKGRNEEAVIYENGVPVLLKDKGREILSEMDEIVEILFSNNEEFKNVIKRALEKINNPHDTISEKLIKDIKEEGYINFHMRLAKEYLNNFKNKEFNLVGYEDLELSTQILILDAIKRGIEFNIMDRLENFISLSDGEKVEYVKQATKTSKDSYITALIMENKLVTKDILRENNIRVPKGKDYDNIDEAKKDFRLFKDEKIVIKPKSTNFGLGISIFPGEYSREDYDKAVEIAFREDSSILIEEFMTGKEYRFLVIGEEVVGILHREPANVIGNGESTIEELVSEKNKDPLRGKGYKTPLEKIKLGEIEEMFLKNQGLSFKSIPKNGEKIYLRENSNISTGGDSIDFTDKIHPSYKEVALKSAKAVKALICGVDMVIDNIEEEAKEKNHGIIELNFNPAIHIHCFPYKGENRKAGEKILDLLFN
What is the function of this protein?
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
What are the official names of this protein?
Glutathione biosynthesis bifunctional protein GshAB, Gamma-GCS-GS, GCS-GS.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
Protein: Y1941_SULIM
Sequence: MIQGDLVQIQELNNEIGRFLIEIARKAIKEEFKLDKLDLSNYNNPILDKKGLAFVTLEKITYNTSSLRGCIGYVEAVAPLKQIVASAAKAAAFSDPRFNPLQKDELSEIIIEVTVLTKPEEIKVKDRWDLPKIIKVGEDGLIVEKGILHSGLLLPQVPMEYCWDEETFLAETCIKASLEPDCWLDNSVRIKRFHGIIFRETRPDGSDIIVVKPSDIKCKLNELLNNF
What are the official names of this protein?
Protein M1425_1941.
Protein: GGR_METM6
Sequence: MRALNDSYDVVVVGAGPAGSMASYNASKNGAKTLLIEKSQEIGTPVRCAEAVPRLEDFGINPDPSFVRSYIKGGYLIAPNGKKVVVKGGKTDGYVVERKVFDKFLAIRSGQAGTQIAVKSRVTKIEKTDDGYDVFVNYLGDEYIVKTKIVIAADGVESNIAEYAGLKSKKSSKEICSCAEYEMTNVKLLDNEMMEFYFGDICPKGYIWLFPKGDTVNVGIGIIDSKKRALDYLDEFLTNPLVEGRLDNAVPIEFKVGGDPVGGPIEKTVADNIMVVGDAAGHVSPLTGGGIGLSMACGVMAGEVAAESTKAEDYSEEFLNLYEKRWKERYYKPLMKDLKYKNILQKLSDEELNAIADSIPENLEEVDVGKLAVKIVAKAPSLLRHFKELL
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase, DGGGPL reductase, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase, Geranylgeranyl reductase, GGR.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Protein: HIS2_NEIMF
Sequence: MGDSVLSAIQQTITQRKSANPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKNPSHLVYEVADLWFHTMILLTHHDLKAEDVLDELARRQGLSGLAEKAARTES
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_CHLPB
Sequence: MKRTFQPHNRKRRNKHGFRQRMATKTGRKIISSRRAKGRHSLSVSSDMGSRRQ
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL21_STRPM
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKIDAEAGAEVTFNEVVLVGGDKTVVGTPVVEGATVVGTVEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RLMI_VIBVY
Sequence: MSAAIYLVKGREKSVVRRHPWIFSRGIDRVEGNPQLGETVDVYGHDGKWLAKAAYSPESQIRARVWSFEKQDVNRAFFVKRIQDAQLLREDVIERDGLTGYRLIAAESDGMPGVTIDRYQNFFVCQLLSAGAEHQKQNIVDALIEVFPDCNVYERSDVSVRKKEGLQETTGVLHGEMPPKSVVIEENGVKISVDIVGGHKTGFYLDQRDSRQQAMKYVKDKEVLNCFSYTGGFGLYALKGGAKRVINADVSQPALDTAKFNAELNEFDISKKRAVFLNADVFKLLREYRDQGTKFDVVIMDPPKFAESKAQLNGACRGYKDINMLAMQILKPGGTLLTYSCSGLMDQVLFQKIIADAAVDAGRSVKFVERFEQAADHPTDTAYPEGFYLKGFACKVL
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_WIGBR
Sequence: MNDNFLNIQIECCLYKQTPSIDKFKFWIKSIFLHFKKVSEINLRLVEKKEIKNLNKKFLKKNYPTNILAFPCIMPNNDQISFLGDLVVCSEIVEKEAKNQNKSVESHWAHIIIHGTLHLLGYDHSNNSNKIEEMEILEIKFLNLFGYHNPYF
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.