Protein: SDC3_CAEEL
Sequence: MSDEPPIVLPTEEDGPFSNCVSIAFVNDKSIPVELRIRKAIRGKVTFTQELVVAARRLYLDGELERPDLNYHVAADFYDPFMIPVPDHRNWEYNPLYPREWPRLIDRDLVQKIKMSNTYKKNQARRKRRRLLRIFHRKRGGEFLNYLWHSKENDVHYKRYMAAYQFPLPFEKCIRDVVREELKDPETSFSKPPSVVHHSKIRPATPDLLKLAKYLGKDRFCFIVTPFKFRSQFRLRYYKKSPFKRSNILEKWLKFKKVRDQGVFNIRDAAREVKKLLQRKNVYHMTDPQCEQEFWDVYRLQMQWLEEDNIEENITMLRENLSKVTDEEFNRSVYIMRPENRASIHDDVTFTTDAEINLKPIVLELFRNNMPLEDIRQVKECIDDMINLTVCQELIPQVATIETVRDYSGVEQHRLKYIRPENELEIMFQLATVLVKNENTHDQEITSPMFALLRTEQYLWSIPLRPFLRMYTDWRKTKLNFKKFRKFSPELVSKAPIDLFKVFLTTNMDKKGVATKDTDCFDYRTASEIKKLYHEEFIRVRPIIEHQRFHRCYTSVITEEPLPNPFYWVHRGQWEKVYECNWKQRVKPLAGRFSWKTKHPNICDLPRLEKDDKQEMEMLAKMREKIREYNKEKEKHPFYVSSSLPEFASTSDFVKFPISNTGIKYTAPRRNQPKVQRSLVTYTRFRLAELEDKDFSFPEEKMLEKNRLLEKLNFEERLQLDALMSKDVKYKPRMIPEKGFLQLQDEKLILKRLCEKEDEWSGKQKRRFPDLYEQATQEAERLGDPDASTSGTSNKELGLLPVWKHDDFRDLKKINVLGSKEYPISSPYLIKRLHYDIHLEIVRDKLKSWIYRTELWEKMKPVYERLKRDKEKREKEWHEMRAAQRAQKEKEEEDQRRMDMGIEHGQESLLKSITPEVEQQILLPISRENSFEEMLPAPQEAYDEDLDQDIDIHFDGAESVCTGIRLDSEDRELVDSPDQVENEEPERVEAVTENIRQEMSDAEMRDLMRKKREQYSMLFPNVPQPFQPLNRFDVTAPGAGIVPPYDEAPDFDLSAYLEEDHVRIPTLSTVEINSLLKDQDLVEEQEIVEEEETPLVVEEPDIPAAPVLSAEEKASRISREMSALRKLPDAAFNYASDRDGVVVEEVETIEEIQEIYNDKLEKMIAARLGSIAQGANIERLSEDQLLGDQGSEDISFEEIQVDLLLESGVEVQVNQSVTISRSSTSFESLLVEDPEEHPEQLPVSASEKANNQIVPEVEVEGSVVPVTNQQEENVTSEGPTLQEGSSIPSSSHIYTVDELLGTESPGPEATETPVAEESPKKKSGKTTRGRPKKVKENLKKRIQPRRGQKEEAAHEPEVVEEQEQVEPEVGPEVVHEPVPAPAAQLETEPIEQQIEEPDKVFEPIIEALPLFETSPVPAPEGNIPSRAHSSDDDVQVISSETDPNGPINLVEQVQNDKLTAYQYSTEELLGEYGELDEAGAPSPSEIVVHDEVLQDEVLQPNPKSSKKRGRRRKKTPPHIAKARKVFTSISKTEEIELAPTPTQQSRKRMANVSSEEATATRRQKRAKVEEPNDSDVSRVLTPEPEDLHETERPGHVGEEGFETPSLRTGRESTASSVKTSRSKRLFLSKNNPVPRMRIQSQAGTNASPTPARRTGVARDSVSPDGASEKLKQLPKSVQDIFEVFDVERSAERGESATVTNLEGPVKIEIEDENWMAPPAITETSRKSKKRLRAEKQQQILDDIKLELNGEPPQKRECEILMERVQVKIEEGVENADCRIVQANFNCKSVEEHETLPLKIIRVFEENEKPVHKFFMTQIIWKEINEAFMTDPEKFMLLVRILFSDRNISGQIYKISMTVTDRIKGFDDDFIKLLTQFPKKLSQEHKPLVDYNKLAHALREKASLHLNNHKITPFTFHGVISNITEMKEKIIGRCEIGMLTDGDRDVLNSTENMLLGAYMKSVLRMTAQSQVSWAHPEYIKRRLEMIYYGWRMFLGSGGFFRVALAINRKDVKPMSQQFRDFFIEYLKDVNENYAKAVELVQMDEDKLMEAMIEKAGLSSIDLLALDEDVQGQVSESHKHKCVQCSIRNQSVYFSSYSLLELHGKLHQNLHELAPEDADDCQDCYETLTSSFEVIVHRINHHHSRRCFFADD
What is the function of this protein?
Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:8431944, PubMed:11937488).  Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:11937488, PubMed:14660541).  Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:14660541, PubMed:9458050, PubMed:8939870, PubMed:9056777, PubMed:8939869).
What are the official names of this protein?
Zinc finger protein sdc-3.
What are the subcellular locations of this protein?
Chromosome. Nucleus. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos after the 40-cell stage.