PharMolix/UniProtQA huggingface dataset:
Protein: AMPP1_METAQ
Sequence: MADSSPQLAKLRSLMKERKVHVYVIPSEDSHSSEYIAACDARREFISGFTGSAGCAIVTLEAAALATDGRYFNQAAKQLDGNWTLLKQGLQDVPTWQEWAASQSAGGKIVAVDPSLLPGSAAKKLNDQVRKAGGADLVPLDENIVDIAWGDSRPERPCQPVSVLPDELAGKPVATKIEELRQELAKKNCPGFFVSMLDEVAWLFNLRGSDIPYNPVFFSYATITPETAILYVDESKLDDSCRAHLRENNVQVKPYDSFLPDARHLHTEVKTKRQAGGDGVVIGNFLISNKASWAMSRALGGDGSVEEMRSPVGDAKAVKNETEMNGMRACHVRDGAALIEFFAWLEDQLVDKKIMIDEVQAADKLEQLRSKQQHFVGLSFPTISSTGANAAIIHYGPEKGSCATIDAGSVYLCDSGAQYRDGTTDTTRTLHFGKPSDAEKKAYTLVLKGLIGLDTAVFPKGTTGFALDCLARQHLWKNGLDYRHGTGHGVGSYLNVHEGPIGIGTRVQYTEVPLAPGNVLSNEPGYYEDGNFGIRIENIMMVREVQTEHCFGDKSYLGFEHVTMVPYCQSLIERDMLTADEKAWLNAYNDEVLKNTRGFFEGDDLTMSWLTRETRPVE
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase P, AMPP, Aminopeptidase P, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: IHFB_BUCAI
Sequence: MIKSELFERIAEQKINISNKMIERAAKEMLEHMIISLANGKRIEIRGFGSFSLHYRSSRIGRNPKTGKSVKLNEKYVPYFKPGKKLRDRANIHK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: P2C30_ORYSJ
Sequence: MAEICCEVVAGSSSEGKGPECDTGSRAARRRRMEIRRLRVVAERGAEEETSGKRRRLDGGGGEASTDEEDREVERARYGFTSVCGRRRDMEDSVSACPGFLPGHHFFGVFDGHGCSHVATSCGQRMHEIVVDEAGAAAGSAGLDEEARWRGVMERSFARMDAEAVASSRGSVAPAPTCRCEMQLPKCDHVGSTAVVAVLGPRHVVVANCGDSRAVLCRGGAAIPLSCDHKPDRPDELERIHAAGGRVIFWDGARVFGMLAMSRAIGDSYLKPYVICDPEVRVMERKDGEDEFLILASDGLWDVVSNEVACNVVRACLRSSGRRERNRSSPTSNLSPRQSSSSGDEAPNDGAPSAAAGSESDEESAAEEDKACAEAAVLLTKLALARQTSDNVSVVVVNLRRRKL
What is the function of this protein?
Together with ABI5, PYL5 and SAPK2, is part of an abscisic acid (ABA) signaling unit that modulates seed germination and early seedling growth.
What are the official names of this protein?
Probable protein phosphatase 2C 30, OsPP2C30.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: P53_EQUAS
Sequence: YSPALNKMFCQLAKTCPVYLRISSPPPPGTRVRAMAIYKKSEFMTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRAEYLDDRNTLRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKEEPCPEPPPRSTKRVLSSNTSSSPPQKEDPLDGEYFTLH
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: SHLD3_HUMAN
Sequence: MTTEVILHYRPCESDPTQLPKIAEKAIQDFPTRPLSRFIPWFPYDGSKLPLRPKRSPPVISEEAAEDVKQYLTISEHDAKSHSYDCTVDLLEFQPSLKKQHLTWSHTLKEQTNSGNLGKQSEKGKQHKRRSWSISLPSNNCTKNVSPLSKKLQDSLKALNLHSLYRARWTIEHTICNSQTLEDIWTKLNQIIRHNELPSCNATIQRHLGQIWVFCDIMYCEYVGSLLKGRLALTGKINLFVHKYGVIFSM
What is the function of this protein?
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs).  During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection.  Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
What are the official names of this protein?
Shieldin complex subunit 3, REV7-interacting novel NHEJ regulator 1, Shield complex subunit 3.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.
Protein: NUMB_HUMAN
Sequence: MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
What is the function of this protein?
Regulates clathrin-mediated receptor endocytosis (PubMed:18657069).  Plays a role in the process of neurogenesis (By similarity).  Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity).  Not required for the proliferation of neural progenitor cells before the onset of neurogenesis.  Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity).  May also mediate local repair of brain ventricular wall damage (By similarity).
What are the official names of this protein?
Protein numb homolog, h-Numb, Protein S171.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner.
Protein: SYG_MYCVP
Sequence: MAPSSSIIDTVANLAKRRGLVFQSGEIYGGTKSAWDYGPLGVELKENIKRQWWRAVVTSRDDVVGLDSAIILPREVWVASGHVEVFNDPLVECLNCHKRHRQDHMQEAYAEKEAKKGVTVDPDAVAMTEIVCPDCGTKGQWTEPRDFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAAEWHRYWIETRLQWYVDLGINRDNLRLYEHPKEKLSHYSDGTTDIEYKFGFAGNPWGELEGIANRTNFDLSTHSKHSGVDLSFYDQANDTRYVPYVIEPAAGLTRSLMAFLVDAYTEDEAPNAKGGVDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRQSWNVEFDDAGAIGRRYRRQDEIGTPYCITFDFDSLEDHAVTIRERDAMTQERVAISEVSNYLAVRLKGS
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MARC2_HUMAN
Sequence: MGASSSSALARLGLPARPWPRWLGVAALGLAAVALGTVAWRRAWPRRRRRLQQVGTVAKLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVIKEDGHMVTARQEPRLVLISIIYENNCLIFRAPDMDQLVLPSKQPSSNKLHNCRIFGLDIKGRDCGNEAAKWFTNFLKTEAYRLVQFETNMKGRTSRKLLPTLDQNFQVAYPDYCPLLIMTDASLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTTVDPDTGVIDRKQPLDTLKSYRLCDPSERELYKLSPLFGIYYSVEKIGSLRVGDPVYRMV
What is the function of this protein?
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752).  As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752).  May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045).  Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).
What are the official names of this protein?
Mitochondrial amidoxime reducing component 2, mARC2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome.
Protein: JNK_DROME
Sequence: MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTNNRTR
What is the function of this protein?
Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity (PubMed:9224720).  Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis (PubMed:8946915, PubMed:9224720, PubMed:10433922, PubMed:11784101).  Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade (PubMed:22227521).  Exhibits cytoprotective activity in neuronal cells in response to wounding to the integument (PubMed:22227521).  Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure (PubMed:10433922, PubMed:11784101).  Regulates the activity of SREBP in neurons and thereby the accumulation of lipids in glia (PubMed:25594180).  Plays a role in positively regulating the expression of DIP2 independently of AP-1, thereby ensuring proper axon guidance in mushroom bodies (PubMed:28396149).
What are the official names of this protein?
Stress-activated protein kinase JNK, dJNK, Protein basket.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: METK_LEIIN
Sequence: MSVHSILFSSEHVTEGHPDKLCDQVSDAVLDACLAGDPFSKVACESCAKTGMVMVFGEITTKAVLDYQKIVRNTIKDIGFDSADKGLDYESCNVLVAIEQQSPDICQGLGNFDSEDLGAGDQGMMFGYATDETETLMPLTYELARGLAKKYSELRRSGSLEWARPDAKTQVTVEYDYDTREGKQVLTPKRVAVVLISAQHDEHVTNDKISVDLMEKVIKAVIPANMLDAETKYWLNPSGRFVRGGPHGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSIVAGGLARRCLVQLAYAIGVAEPLSMHVETYGTGKYDDAKLLEIVKQNFKLRPYDIIQELNLRRPIYYDTSRFGHFGRKDELGTGGFTWEVPKKMVE
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: RNH2_PARPJ
Sequence: MTLSRAPRRKTVAGASAQQVGLNFETPDDIVCGVDEAGRGPLAGPVVAAAVIFDPSKPMIRGLDDSKVLTAKKRDELYDKIVDRALAYCIASATVEEIDSLNILHATMLAMKRAVEGLSVVPTLVKIDGNRCPTLSVRSEAVIGGDALVKSISAASILAKVTRDRMLLELHQTHPVYGFNAHAGYGTPQHLKALREHGPCEHHRRSFAPVREAHLRLSTGMPLPAGEVIVVSEVMFDDDAFGERGSAV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE6_HPV42
Sequence: MSGTSASSQPRTLYQLCKEFGLTLRNLQISCIWCKKHLTGAEVLAYHFKDLVVVWRKDFPYAACAFCLEFNSKICALRHYERSAFWYTVEKETGLLLEEQQIRCALCQKPLSQSEKNHHIDTGTRFQFILCQWTGRCTHCRGQCVERRLP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: CDN1B_FELCA
Sequence: MSNVRVSNGSPSLERMDARQAEYPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGNRQAVPLIGSQANTEDTHLVDQKTDTSDNQTGLAEQCPGIRKRPATDDSSPQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
What is the function of this protein?
Important regulator of cell cycle progression.  Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA.  Involved in G1 arrest.  Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes.  Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation.  Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
What are the official names of this protein?
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1.
What is the protein family that this protein belongs to?
Belongs to the CDI family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
Protein: PYRC_STAAN
Sequence: MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMMYEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVIRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPFIGYKVYGNPILTMVEGEVKFEGDK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: PROFW_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEDHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-4, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TOLB_SACD2
Sequence: MILGRKHLAKAGSKWLAGSSQWALSLMLILAAGMARAELVIEITQGADNPTPIAVVPFGGNGGLSENVSRIISADLDRSGLFESKSPENMLSFPSKQADIFYRDWRILGTDYLVIGDIQRSESGYVAEYGLYDVLQQKKMLGKVLSVGPTGLRDMAHKISDDVYQALTGIRGAFSTKILYIEDMGPSVKERYRLIKADADGAREQLIFKSSEPLLSPAWSNDLTQVAYVSFETSRPAIFRHNLITGKREQLTNFKGLNGAPAWSPDDSKLALVLSKDGNPEIYILDIATRALQRVTKTHSAVIDTEPNWTADGKGIIFTSNRGGNPQIYQVGLATGRVERLTFEGDYNARPRVTPDGKSLVMVHREDGVFHIAWQDIQSGDMRILTETWLDESPSIAPNGAMLLYATQHNNKGVLAAVSIDAGVKFRLPSKQGSVREPAWSPYAK
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: OPGC_ECOLU
Sequence: MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAEPSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKTLFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR
What is the function of this protein?
Necessary for the succinyl substitution of periplasmic glucans.  Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
What are the official names of this protein?
Glucans biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family. OpgC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCAM_TOBAC
Sequence: MDSALPVSAIGFEGFEKRLEISFFEPGLFADPNGKGLRSLSKAQLDEILGPAECTIVDSLSNDDVDSYVLSESSLFVYSYKIIIKTCGTTKLLLAIPPILKLAETLSLKVQDVRYTRGSFIFPGAQSFPHRHFSEEVAVLDGYFGKLAAGSKAVIMGSPDKAQKWHVYSASAGPIQSNDPVYTLEMCMTGLDREKASVFYKTEGSSAAHMTVRSGIRKILPNSEICDFEFEPCGYSMNSIEGAALSTIHITPEDGFSYASFEAVGYDMKTMKLGPLVERVLACFEPDEFSIALHADVATKLLERVCSVDVKGYSLAEWSPEEFGKGGSIVYQKFTRTPFCGSPKSVLKGCWKEDEEKEEKE
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: YGGN_ECO57
Sequence: MMRKMLLAAALSVTAMTAHADYQCSVTPRDDVIVSPQTVQVKGENGNLVITPDGNVMYNGKQYSLNAAQREQAKDYQAELRSTLPWIDEGAKSRVEKARIALDKIIVQEMGESSKMRSRLTKLDAQLKEQMNRIIETRSDGLTFHYKAIDQVRAEGQQLVNQAMGGILQDSINEMGAKAVLKSGGNPLQNVLGSLGGLQSSIQTEWKKQEKDFQQFGKDVCSRVVTLEDSRKALVGNLK
What are the official names of this protein?
Uncharacterized protein YggN.
Protein: 82J17_TRIFG
Sequence: MDSFLSQPITIVLAILSVLLYNIWKIRKPSNKFQKGMKLPQLSFALPLIGHLHLLGNQIPLAKTFASFADKYGPIFQIRLGAYPTLVISNKEAIKECFTTNDKILASRTKSTHGILLGYNHASFACAPYGRFWAKIRKVTMLELLSSRRVESLRHVYESEIDTLVKDLSLYVKVGKVEVVISEWMERLTFNIITKMICGKRYFEYLQDVDDVEANGNIVKLIKEVMHISGELVPKDVIPILGWFGFEGEVLKSMKRVSRDLDEVVGKWVEEHIEKSDDGVNNSNEKQDLIDVMLSVIEDDPDSGNDRDTIIKANIVNLMIAGSDTTSTTMTWILVLLLNNMNALKRAQEEIDQHIGRDRKIESSDIKNLVYLQAIVKETLRLHPTLPLSIPHEATEDCNIQGYYVPKGTRLFTNVWKLHRDPSIWLEPEKFSPERFINENGEIDHESHQFEYLPFGLGRRACPGSMFATQVIHIAVARLIHLFDFEVPINEVVDMKQGTGLILSKFTPLKVLLTPRLPYELYQ
What is the function of this protein?
Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e. g.  furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones (PubMed:31324795).  During the 5,6-spiroketalization of cholesterol, may catalyze the 27-monohydroxylation of furostanol-type steroid to an intermediate product that undergoes a stereospecific formation of the terminal heterocycle to yield diosgenin (PubMed:31324795).
What are the official names of this protein?
Cytochrome P450 CYP82J17, PpCYP82J17.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: COQ2_DICDI
Sequence: MIKSILSLQNFKFIKPCTNSSILKYNNNNNTNNNNNNNGINKYNSTFNNNNSNFSNKNLFSSKQYQQQSICNIPILSTISYHNKNNTNINTIINNNNSSNNNLINLNDKFNNLNNKTSPIIFNKNYSTTVSTLLDDNNSNSNNNNNSNNNKPSTTFVNDWISKFPNSVQPYLRLSRVDKPIGVWLLLYPCCWSISLAAPAGSFPDLKTMLVFGIGAYVMRSAGCVINDMADYKFDSKVERTKTRPIASKQLTHKQSLIFLGGQLLASFGLILSSLNYYTIALCASSLPIVVLYPFMKRFTYYPQFVLGLAFNWGALAGYSAIAGSCNWSIVAPLYLAGISWTMVYDTIYAHQDKRDDILVGVKSTALKFAEKSRIILSVFSGLVISGMFLTGIAANMPLFYYLGTAACSSHLIWQLKTVDFNNPSSCLEKFISNKNFGLYFLLIIIVSKLLQDKENENEIQKK
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
What are the official names of this protein?
4-hydroxybenzoate polyprenyltransferase, mitochondrial, 4-HB polyprenyltransferase, Para-hydroxybenzoate--polyprenyltransferase, PHB:PPT, PHB:polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: SYP_ONYPE
Sequence: MKTMKRVKTVTARSSDFGKWYTDVCLKAELIAYSEAKGFIIYLPYGYALWENIQKHLNCTLQKTGHQNVYFPLVFPEKLFHKEKNHIQGFSPEAAMITTTGKKNLSEKLVIRPTSEILFSQYYSKTITSYRDLPKLYNQWCNVVRWEKTTKPFLRGKEFLWQEGHTVHATEQEAMQQTLSILDIYQKLGKNLLALPFVCGKKTETEKFAGALITYSIEALMHDGQALQAGTSHYLGTNFAKSFQIQFQDCDHQKKYVHQTSWGVSTRLIGALIMVHSDDEGLVLPPYVSPMQIVIIPLQPQDDAVKQTSENLFSILQKNYRVHLDLQDKTAGWKFSQYELKGVPLRIEIGKRGLENDEVTIFQRYNFAKQNIKTKDLPSQIPQLFETIHNNMYQKALQHLEQNRKQATTYEEFKTYLKQGGYVAMSISGTDAELQIKQETGATARVILETNLITANCPVTNKKALQTVLFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.