PharMolix/UniProtQA huggingface dataset:
Protein: POLG_LIVSB
Sequence: SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSVDVWLDAIYQESPAKTREYCLHAKLSETKVAARCPTMGPAALAEERQIGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGYVYDANKIVYTVKVEPHTGDYVAANETHKGRKTATFTVSSEKTILTLGEYGDVSLLCRVASGVDLAQTIILELDKTAEHLPTAWQVHRDWFNDLALPWKHEGNPHWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGNKYHLKSGHVTCEVGLEKLKMKGLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIGRVFQKTRKGIERLTVIGEHAWDFGSAGGFFSSIGKAVHTVLGGAFNSIFGGVGFLPKLLMGVALAWLGLNTRNPTMSISFLLTGGLVLAMTLGVGA
What is the function of this protein?
Binds to host cell surface receptor and mediates fusion between viral and cellular membranes.  Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM.  They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E.  The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers.  prM-E cleavage is ineficient, and many virions are only partially matured.  These uncleaved prM would play a role in immune evasion.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CSPJ_SALTI
Sequence: MTTKITGLVKWFNPEKGFGFITPKDGSKDVFVHFSAIQSNEFRTLNENQEVEFSAEQGPKGPSAVNVVAL
What are the official names of this protein?
Cold shock-like protein CspJ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_RICPR
Sequence: MKVIFMGTPEFAVPTLKKLIIHHEVKAVFTQQPKAKGRGLHLAKSPIHQLAFEHQIPVYSPSTLRNDETINLIKKIDADIIVVIAYGFIVPKAILEAKKYGCLNIHPSDLPRHRGAAPLQRTIIEGDRKSSVCIMRMDSGLDTGDILLKEDLNLERRITLDELSNKCAHLGAELLIKTLANIDNIVPIKQSSNGITYAHKLTKAEGKINWYESAYSIDCKIRGMNPWPGAYFSYNDKIIKILRAEYFNYNHHFIPGTVINNKLEIACGSGILRVKKLQQESKKALNIEEFLRGTNILKDTILK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SP2SB_BACSU
Sequence: MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E. coli.
What are the official names of this protein?
Stage II sporulation protein SB, Antidote protein SpoIISB, Antitoxin SpoIISB.
What is the protein family that this protein belongs to?
Belongs to the SpoIISB antitoxin family.
Protein: NIFH_PELPB
Sequence: MRKVAIYGKGGIGKSTTTQNTVAGLAEMGKKIMVIGCDPKADSTRLLLGGLQQKTVLDTLREEGEEVELEDIIKDGYRNTRCTESGGPEPGVGCAGRGIITSVNLLEQLGAFDDEWDLDYVFYDVLGDVVCGGFAMPIRDGKAEEIYIVCSGEMMAMYAANNICKGILKYADTGGVRLGGLICNSRNVDNERQMIEELAKKIGTQMIHFVPRNNFVQRAEINRKTVIEYDPTHEQADEYRALAQKINDNKMFVIPKPLEIEELEALLIEFGIAN
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: SYA_LEPIN
Sequence: MKPKSVSEIREIFLNYFKDKSHNVVPSSSLLPAGDPTLLFTTAGMVQFKPLFTGAVELPYTRATSCQKCLRTTDLEVVGKTERHCTFFEMLGNFSFGDYFKEEAIEYALDCSVNHFGFDKNKIWVTVYTDDDEAEKIWLSKGIPKERITRLGKKDNFWGPAGDSGACGPCSELYLDRGIEKGGPNCATSGTCKPGCDCDRFLEFWNIVFNQFNQDTEGNLHPLKQTGIDTGSGLERVALLLQEVDSVYDTNELRKIISFYEELSGISYEDKTLSEISEKKNNNQQISSQVRNETKSIQDSRKTAFRVVTDHIRSVLFSIGDGIYPDRTGRGYVIRRLIRRATLFGRKLNFKEPFLYKLVDKVIEIYKARYPELQRNAAAITKTILVEEELFLKTLELGLEKIESLVQKTKAGGKTIFSGADAFLLYGTYGFPAEMTEEIVAEQGLDFDKKGFQEELEKDRQFSRESWKVNKVSLMTGLNVDKTEFLGYSSVSGKGNITHLFYNSPKSSNSLSQVDSKLQSSTPAGTGSYDSKQVSSLKEGQAGAIVLNKTPFYPEGGGQVGDIGFLRQGKNVFKVFDTQKENDSIIHFGEVLSGEFIVSQELEAEVEITRRERLKFHHSGTHLLNGALRTLLGDHVLQKGSIVSPEYLRFDFSHPSSLTSEEIRQIESWVNESIRKNFPVETKELSIEDAKKTGAVATFGEKYGERVRVVQMGDASIEFCGGTHVSRTGEIGYFFIKKESSPGAGNRRIEGVCGPAVIETFQNRFSELTESVQNLNLKIKSELGEEGTKILILSFIPGPDEIREKLEKEGASAVSFFRDLSENIATKIEENTSSFLKIKKNLAERDFENNTSVIENVLASSVDTGIGKIVSAIFEDKDPNSLKGLSDNLKVREKNLLVILGSRNSENASIVITCSSELTLKGIHCGNLIKTACELLGGKGGGRPDMAQGGGKEKQNLESAIAGVINEAKQILTGERV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GET3_XENTR
Sequence: MAAPADDEFEDAPDVEPLEPTLSNVIDQRSLRWIFVGGKGGVGKTTCSCSLAVQLSRVRESVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPDEIFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQLVFPEPEKPCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGAENVNTFSKLLLEPYKPPSGK
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Guided entry of tail-anchored proteins factor 3, ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: RS9_WOLSU
Sequence: MAKIYATGKRKTAIAKVWLTPGSGKLTVNGTTLNDWLGGHEAIKMKVMQPLLLTKQEKSVDIVSVTLGGGYSAQAEALRHGISKALSAYDIAFRAILKPKGLLTRDSRVVERKKYGKRKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CH10_HOLOB
Sequence: MTKFKPLGDRILVKRVEAEERTSGGIVIPDTAKEKPIEGTVIAVGPGARDPQGNLIALEVKQGDRVLFGKWSGTEVKLSGEDYIVMKESDVFGTIA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLGT3_HUMAN
Sequence: MRRLPRALLLQLRLALLVAAGAPEVLVSAPRSLVWGPGLQAAVVLPVRYFYLQAVNSEGQNLTRSPAGETPFKVVVKSLSPKELVRIHVPKPLDRNDGTFLMRYRMYETVDEGLKIEVLYGDEHVAQSPYILKGPVYHEYCECPEDPQAWQKTLSCPTKEPQIAKDFASFPSINLQQMLKEVPKRFGDERGAIVHYTILNNHVYRRSLGKYTDFKMFSDEILLSLTRKVLLPDLEFYVNLGDWPLEHRKVNGTPSPIPIISWCGSLDSRDVVLPTYDITHSMLEAMRGVTNDLLSIQGNTGPSWINKTERAFFRGRDSREERLQLVQLSKENPQLLDAGITGYFFFQEKEKELGKAKLMGFFDFFKYKYQVNVDGTVAAYRYPYLMLGDSLVLKQDSPYYEHFYMALEPWKHYVPIKRNLSDLLEKVKWAKENDEEAKKIAKEGQLMARDLLQPHRLYCYYYQVLQKYAERQSSKPEVRDGMELVPQPEDSTAICQCHRKKPSREEL
What is the function of this protein?
Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001).  Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001).  Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563).  May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001).
What are the official names of this protein?
Protein O-glucosyltransferase 3, KDEL motif-containing protein 2, Protein O-xylosyltransferase POGLUT3.
What is the protein family that this protein belongs to?
Belongs to the KDELC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: ACP_CAMFF
Sequence: MAVFDEVKDVVVEQLSVAPDAVKMESKIIEDLGADSLDVVELVMALEEKFEVEIPDSEAEKLISISDVVNYIDGLKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC2_NEOYE
Sequence: MDNRRSLAQPSFSNKVIDTNELKNLIVWAFRNYGIARAANMADKLKDLGFHYATQAGISLSLEDLRIPPSKQSLLLGTIEDIKATENKYRRGEITAVERFQKVIDTWNNASESLKQEVIKYFKETDPLNAVSMMAFSGARGNISQVRQLVGMRGLMADPQGQIIDLPISSNFREGLTVTDYFISSYGARKGLVDTALRTADSGYLTRRLVDVSQDVIIREVDCKTNKGIILEDLVDTQKILINLEQALSGRVLAENVFHPETNCLIAHTNQDVSPKLAKEITKAGIKKVLVRSPVTCNSRSSVCQYCYGWNLAHGRLVDLGEAVGIIAAQSIGEPGTQLTMRTFHTGGVFTGELAEQIYAPIDGQLIDLDIESYTDVRTRHGEQALITKKPTQVTIRSKKNQKSIINLSKGTTLLICDGELVSKDQVIAESPRRNRLMTERAQKHVVSDLSGKICFSNLTVEETDNNQYTTRITKTGGLIWVLSGEVYSISDSANVIVHKEDKTKAGTILAQTELINHYAGEVRIHQNTNSSITNIQVITESIVIPGCYIYTDVIHKKESYILETEKKQKFLFKAIPNQKIQDGYTVAELISDTYKTTSGGIIKYLDLNVSKKKTGLDKDAYEILSPGYILWISEETHEINKDSSLILVHNGDVIESGTELVKNIFSKSSGIAEIIEKDGIVREIIIKPGSIYKLSEVYSNNDKSRGFLRPGERLHNNISTDKLVYWEYIENEQMPYILIRPVIVYSIPETKSSLIENLVSQKPSQTKLKLVKRTPFRDGERVKSIEGVHLVTTNLVAEIEHRDDNLISSIEFSAKESGNNYFDLRLSTFETLSIKSIDVNKSEKQQSQTRIIVKNGEYIKPFTVVASTEIIAMSEGTVEEIYSEKNTSRRILIATSSDKKTFNIGKSTVKVSVGDWIRCGDFITENMTSLDSGQIIEISSRSVTLRIARPYLVSNGAILHVDNNALIRRGETLAILVFDRAKTGDIIQGLPRIEEILEARKKTDVLLNPHDILDASFDLYIECGLALYEAARLSFQEIQLLLVKEVQLVYQSQGVNISDKHVEVIVRQMTSKVKIENGEETGYLPGELVELQKIEQTNKAITLRNKINASYRPVLLGITQASLNTESFISAASFQETTKVLTEAAISGKLDWLRGLKENVIIGRLIPAGTGFNMYDNCNGSSLEKKNLTANTNDESTISSVRDDLDDIILDDRTARNYFSNKSVE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YIDZ_SALEP
Sequence: MKKSLTNLDLNLLLCLQLLMQERSVTKAAKRMNVTPSAVSKSLAKLRAWFDDPLFVNTPLGLAPTPLMVSMEQSLADWMQMGNQLLDKPHHQTPRGLKFELAAESPLMMIMFNSLSQQIYQRYPQATIKVRNWDYDSLEAITRGEVDIGFTGRESHPRSRELLSLLPLAIDFEVLFSDLPWVWLREDHPALREAWDLDTFLRYPHISICWEQSDTWALDDVLQEMGRKRHIALSLPGFEQSLFMAAQPDHTLIATAPRYCQHYNQLHQLPLVARPLPFDAQQREKLMVPFTLLWHKRNSHNPKIVWLRQAINTLCRRLI
What is the function of this protein?
Involved in anaerobic NO protection.
What are the official names of this protein?
HTH-type transcriptional regulator YidZ.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: HIS1_PROMS
Sequence: MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESELKVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLIKIDDLYYSTARLIGNPLSMRLDDNHLRDTILSIESTNAL
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNPTG_BOVIN
Sequence: MAARLAGLAVVLGFAARGPAPGGAAKMKVVEEPNTFGLNNPFLPQTSRLQPKRDPSPVSGPAHLSRLSGKCFSLVESTYKYELCPFHNVTQHEQTFRWNAYSGILGIWHEWEITNNTFRGMWMRDGDACQSRSRQSKVELTCGKSNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLPAALQQRWDQLEQDLVDELITAQGYEKSLRAIFEDAGYLKTSEPNEAAQQEGGTKGLRFETLESCQEAHKALSQEIKRLQGVLTQHGVPYGKPTETPSSEHWGPQVPTAGMAEPLRGDPGLRGDTL
What is the function of this protein?
Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus.  Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB).  Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity).
What are the official names of this protein?
N-acetylglucosamine-1-phosphotransferase subunit gamma, GlcNAc-1-phosphotransferase subunit gamma, UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus.
Protein: Y1298_ERWT9
Sequence: MRSFLHVIWQYLRAFFVIWLCLYAGRGVAWLLPIAIPASILGMLLLFILLSANILPLAWVKPGCNLLIRYMALLFVPISVGIMDHMDILSAQFAPIVISCAVGTLIVLMTTGMVAQRMDNRHSRRLEGKDE
What are the official names of this protein?
UPF0299 membrane protein ETA_12980.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSCA_RICFE
Sequence: MQIIEITEPEQADFKQERQIAVGIDFGTTNSLIAIATNRKVKVIKSRDDKELIPTTIDFTNENFIIGNNKGLRSIKRLFGKTLKEILNTPALFSLIKDYLEANSSELKLNFANKQLRISEIAAEVFIYLKNQAEEQLKTNITKAVITVPAHFNDAARGEVMLAAKIAGFEVLRLIAEPTAAAYAYGLNKNQKGCYLVYDLGGGTFDVSILNIQEGIFQVIATNGDNMLGGDDIDVVITQYLCNKFDLPNSVDTLQLAKKAKETLTYKDSFNNDNISINKQTLEQLILPLVERTINIAKECLEQAGNPKIDGIILVGGATRTPLIKTELSKAFKVQHISKRFRQDEFKGEPAGRIKIREHRQVLQNSLVSNFMEYAVDILSDIDPDKAVVWGAALQAENLTAPHTNSLLIDVVPLSLGVELYGGIVEKIIMRNTPIPISVVKEFTTYADNQTGIQFHILQGEREMAVDCRSLARFELKGLPPMKAGNIRAEVTFAIDADGILSVSAYEKISNTSHTIEVKPNHGIDKTEIDIMLENAYKNAKIDYTTRLLQEAIIEAEALIFSIERAIAELTALLSESEISIINSLLDNIKEAAHARDRILINNSIKEFKSKIKKSMNTKLNIIINDLLKGKNINQTK
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CPS2_ISOER
Sequence: MSSSSNVTSLPRLTTAGGVFPREMVRVHSSCNILRSKAKVGGINYFNPGNIKCVEVHKSRQVAVAAVKSLEYETEKPTNQDVVSEKMRVLSERIGTMLQNMNEGEISISPYDTAWVALVEDTDGRPQFPTSLEWISNNQLADGSWGDRKFVIYDRILNTLACVVALTTWNMHPHKCNRGLRFIRDNIEKLENENEELMPIGFEVVFPSLIEAAQKLGIEIPHIDSPCIKKIQAMRDFKLKRIPMELLHKKPTSLLHSLEGMQGLVWEKLLDFRSDGSFLCSPSSTAYALQHTKDELCLQYLLKAVKKFNGGVPNVYPVDMFEHLWCVDRLQRLGICRYFRAQIKEMLDYVYKYWTDKGICWARNTNVQDVDDTAMGFRLLRMHGYDVSTDVFKQFEKAGEFCCFPGQSTHAITGMYNVYRTSQIMFDGEDILADAKNYSATFLHQKRLASELVDKWIITKDLPGEVGYALDVPFFASLPRLEARFFLEQYGGDDDVWIGKTLYRMPYVNSDTYLELAKLDYKKCQAVHQLEWKSIQKWYRDCKLGEFGLGEKRLLLAYFLAASTAFEPEKKGERLAWAKTAFLVETIASQQLSHEQKREFPNEFEHGSSLNMENGGRYKTRTRLVEILSNTVSQLSFETLVAEGRDIKQQLSNTWQKWLKTWEEGGNLGEAEAQLLLQTLHLSSGLDESSFSHPKYHQLLEATCKVCNQLRLFQNRKAHDAQGGISDLVIGTTFQIEASMQELVKLVFTKSSEDLDSITKQSFFAIARSFYYTAYCDAGAINSHIYKVLFENID
What is the function of this protein?
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities (PubMed:22284743).  Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP) (PubMed:22284743).
What are the official names of this protein?
Ent-copalyl diphosphate synthase 2, IeCPS2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsc subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACCA_XANAC
Sequence: MNPNYLDFEQPIADLEAKIQELRKASTGPAVNVETEVRALRDKLRVRTAQIFRDLSAWQVSQLARHPQRPYTLDYINTICDEFHELAGDRAYADDKAIVGGLGRIDGRPVVIIGHQKGRDTKTKVARNFGMPRPEGYRKALRLMKLAERFRLPLLTFIDTPGAYPGIGAEERGQSEAIARNLLEMAELKIPVICTVIGEGGSGGALAIGVGDRTLMLEYGTYSVISPEGCASILWKDAAKAKDAAEQLGLTAKRLKGLGLVDKVIREPTGGAHRNPEQMGKRLKAVLLNELDALEKIPVDTLLQQRYERLRSYGAYEGH
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VHT1_SCHPO
Sequence: MASEWPETSRASSVEENPKLNIPEIVESVSDSKPSLKNQFSTTVIDSSDLNVFNDGAETTVKEQEFTSSELRRLQKLRLKMDLRIIPCLWILYFLSCCLRFTVSLSFTMNTAQGHSLIQTLSGYSAHYLALGLALFYVGYIIFEVPSNLMMAFIEPRIWVSRIQLTIGVVGACHAVLGTKHGNAQSYVALRFFLGVAESGLWPGLAYYMSRWYRGKHLGKRIGWYYTAAQIAAAAVSLVSAGFQKMDGARGLYGYQWMFLIWGVVAIAQALSIPWWLPAVASKEHRKSLSSFIPLPKWMKTLSPQRIGFLTPADKSLHSRYIAEMNVGKRWQWSDLLKSCLDLRVWPFILMYFGIVGVGNGIFNYCTLIIEEINPSFSGIDISLLNAPIWLADALGIVTVMPLYDRFHKKFSFFTGSCLIIIAGLAVANYAPRAWSRYGGLLMIGFGLGPTVPICMAWCSASMAKTYGDVGVASSLALVTGLGNLGSVVTTYALYSGWPGDPTFRKSNDVCIALIGVSIIACGIEFLLDKTGFGQFNASFNNHDHEVEDEQEMTDIKPALPSSQQADA
What is the function of this protein?
Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons.
What are the official names of this protein?
Vitamin H transporter 1, H(+)/biotin symporter vht1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Allantoate permease family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PARP3_MOUSE
Sequence: MAPKRKASVQTEGSKKRRQGTEEEDSFRSTAEALRAAPADNRVIRVDPSCPFSRNPGIQVHEDYDCTLNQTNIGNNNNKFYIIQLLEEGSRFFCWNRWGRVGEVGQSKMNHFTCLEDAKKDFKKKFWEKTKNKWEERDRFVAQPNKYTLIEVQGEAESQEAVVKALSPQVYSGPVRTVVKPCSLDPATQNLITNIFSKEMFKNAMTLMNLDVKKMPLGKLTKQQIARGFEALEALEEAMKNPTGDGQSLEELSSCFYTVIPHNFGRSRPPPINSPDVLQAKKDMLLVLADIELAQTLQAAPGEEEEKVEEVPHPLDRDYQLLRCQLQLLDSGESEYKAIQTYLKQTGNSYRCPDLRHVWKVNREGEGDRFQAHSKLGNRRLLWHGTNVAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVTTMHCGGHQVGYMFLGEVALGKEHHITIDDPSLKSPPSGFDSVIARGQTEPDPAQDIELELDGQPVVVPQGPPVQCPSFKSSSFSQSEYLIYKESQCRLRYLLEIHL
What is the function of this protein?
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253).  Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity).  In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity).  Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity).  ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).  Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (By similarity).  Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity).  Suppresses G-quadruplex (G4) structures in response to DNA damage (By similarity).  Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334).  Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity).  May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity).  Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965).  In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity).
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, DNA ADP-ribosyltransferase PARP3, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly [ADP-ribose] polymerase 3, PARP-3, Poly[ADP-ribose] synthase 3, pADPRT-3.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1- dependent manner.
Protein: Y3105_BACHK
Sequence: MVAHAEINNLSFVYADENEYALQHISLSIQKGEFIVLAGGSGSGKTTLLKHFKKELLPIGKRTGDTYYDGTLLENVPDLLSAQEIGMVFQNPENQLVMDTVIQELAFSLENIGLPSHIIQKRIAELISFLGFQDLLHQSVHTLSGGQKQLVNLAAVLVMQPKLLLLDEPTAQLDPIAAKEFLGLLKRINEELGITIVLSEHRLDEVIPLATRVICMSNGRIVYDGSPKTVVANMWEVEKFRPFIPQIPRLFLEWNAKDIPFTVREAQMKLNNFSAISYVNKPIAQSEKQEVILSAEHISFQYEKNSPLILRDLTVSIEKGEWVALVGKNGTGKSTLLTLLAGLQKARRGKVKWNGKVIHKIDSKERFKSIGYVSQHPYYHFTFDTVWDEVYERARELYGEQGKEIAEHQLKKFWLYGLKERHPHDCSGGEQQLLALCTTLLSKPTLLLLDEPTKGLDPWKKERVGELFRKLQKEGTTIVMATHDIEFAAKYVDQCMMLFDGAVIMNDAPKEFFSGNFFYTTSINRFIRKELPYALTWEDVYEACPNDILHS
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein BT9727_3105.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ASSY_MYCSK
Sequence: MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMDVVRQRALDCGAVEAVVIDARDEFAEDYCLPAIQSNALYMDRYPLVSALSRPLIVKHLVDAAREHKGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDVYDYTEDPTLNWSTPDEVIVGFDKGVPVSIDGRDVTVLQAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRTTDQKWGELVYDGLWFSPLKTALESFVAKTQEHVSGEIRLVLHGGHIAVNGRRSQESLYDFNLATYDEGDTFDQSSAKGFVHVHGLSSSISARRDLGIK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.