PharMolix/UniProtQA huggingface dataset:
Protein: OTC_CERSK
Sequence: MNHFLDIHKTDTAELRQMMDSAHAMKAARKGRPKGQFDEDQPLAGRMVALIFEKPSTRTRVSFDVGVRQMGGQTMVLSGKEMQLGHGETIADTARVLSRYVDLIMIRTFEEATLLEMAEHATVPVINGLTNRTHPCQIMADVMTYEEHRGPIAGRKVVWAGDGNNVCASFLHAAGQFGFDFTFTGPPTLDPEAEFVGYAREKGRRVSIERDPAKAVAGADLVVTDTWVSMHDPQSARERRHNQLRPYQVNEALMAQAKPDALFMHCLPAHRDDEATSAVMDGPHSVIFDEAENRLHAQKAIMRWCLGL
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEP4_HAEIN
Sequence: MIYFTMFLLGGILGIALWFYLSGFITRLQQNIYAIYVELFPQNRSPFQPHFASIQQKKCGHILRYFFSIGVGFIFLQIAFKDSIFTVWIGLTLIILWTISYLDWHYQLISTTPCLWLLTLGLFGADNNFSLLTLSESIKSAASFFIVFYVIYWLAKFYYGKEAFGRGDYWLAMALGSFIHLETLPHFLLLASVLGICFSLIHRKKKEFLPFAPFMNLSAVIIYFVKYYGY
What is the function of this protein?
Plays a role in type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.  Substrates include proteins required for biogenesis of the type II general secretory apparatus.
What are the official names of this protein?
Prepilin leader peptidase/N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GOSR1_RAT
Sequence: MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSARDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTHSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
What is the function of this protein?
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport.  It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.  May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14).  Participates in docking and fusion stage of ER to cis-Golgi transport.  Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
What are the official names of this protein?
Golgi SNAP receptor complex member 1, 28 kDa Golgi SNARE protein, 28 kDa cis-Golgi SNARE p28, GOS-28, GOS28.
What is the protein family that this protein belongs to?
Belongs to the GOSR1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi apparatus.
Protein: RL14_ECO57
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: KCY_STRGG
Sequence: MSTTVETARSSVIVAIDGPSGTGKSSTSKAVAAKLGLSYLDTGAQYRAITWWMLTNGVDVGNPEEIATAAAKPVIVSGTDPAAPTITVDGEDASGPIRTQEVTSKVSAVSAVPEVRTLITALQRSIAAAATGGIVVEGRDIGTTVLPDADLKIFLTASPEARAARRSGEVKGSDLSATREALIKRDAADSGRKTSPLAKADDAVEVDTTELTLQQVIECVVTLVEGKRVAA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_HAEIN
Sequence: MSMQDPIADMLTRIRNGQAANKVAINMPSSKLKVAIANVLAAEGYIESVKVLEGAKPELEITLKYFQGKPVVESIQRVSRPGLRIYKRKDELPKVMGGLGVAVISTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PLSX_STAA9
Sequence: MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKNLEIMLFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSVGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSFELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKLAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: OS9_GIBZE
Sequence: MRRFNLILLASLQLVGARSPGGFNIHEDLLTYPQFEVVFDNQYISEKDAHSLLDSQHPTYSADFAQSTLGQAREADARDNEAENKDQDGPSYKYELMKMPPNEYLCSIPILQSPEAENKTANELAKAEEARELTRATASGWELLSELQDSCLYFMSGWWSYSFCNNREIVQFHALPSIPNGQPPKRDPHTMEFTLGRVPAVPASAAHQAKMNGQEAPPPAELQVKGDQRYLVQRLEGGTICDLTGRERTIEVQYHCVPGMKADRIGWIKEVTICAYLMVVNTPRLCNDVAFLPPEETRANPITCKLILDKLNEPPSLDQTVPLAQDEAQVPLKQEDTGAKSGDAAPRDVGKEPINIGGVLVGARNVLSGADEAGKPPAKLPPPRSYFSNSNTDTERFLKVVASGKSKEDGGEMEVLGNEELEKLDLKPSVVKDMTERMRKLAGKYGWKLELVELPGGEKELRGYIDADEEELAKNKAKLKKEKEAAAKAKGDDEEEVVEGSEEQFFDKKDEL
What is the function of this protein?
Lectin involved in the quality control of the secretory pathway.  As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
What are the official names of this protein?
Protein OS-9 homolog.
What is the protein family that this protein belongs to?
Belongs to the OS-9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: RT34_BOVIN
Sequence: MARRKVRPRLIAELARRVRALREQRERPRDSVRYALDYETLIRPHSGRKLPLRAWVDVRRESRLLQLLGRLPFFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGKAWGILTFKGKTESEAREIEQVMHHDWRLVPKHEEAAFTSFTPAPEETPRPVPYPPLLRAMILAERQKNGDPSTEEPMLSLERIRTDPWDYPENQEAKKKTKGTAV
What is the function of this protein?
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
What are the official names of this protein?
28S ribosomal protein S34, mitochondrial, MRP-S34, S34mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS34 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KCC2B_BOVIN
Sequence: MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIMAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGATMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSTHTTIEDEDTKARKQEIIKITEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle.  In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.  This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.  In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling.  Also regulates the migration of developing neurons.  Participates in the modulation of skeletal muscle function in response to exercise.  In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.  In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway.  Phosphorylates reticulophagy regulator RETREG1 at 'Ser-147' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Synapse.
Protein: CRGS1_CHIID
Sequence: MGKIIFYEDRNFQGRHYECSSDCADLSPYFSRCNSIRVESDWWVLYEKPNYMGYQYVLTRGEYPDYQRWMGFNDCVRSCRMLPHTGRSYRMRIYERLTFGGQMMEIMDDCPSVYDRFRYRDIHSCQVMDGYWIFYEHPNYRGRQYFMRPGEYRRYSDWGGYSSTVGSLRRIME
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin S-1, Beta-crystallin S-1.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: TBA_ENTDO
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPSGQMPSDKAVGGKDDSFNTFFSETGSGKHVPRAVFVDLEPTVVDEIRTGLYRQLFHPEQLITGKEDAANNYARGHYTIGKEHIDLVLDRVRKLSDQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVATAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICKRNLDIERPSYTNLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLAVAEVTSACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDTFEAEEEEGGDEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PG154_VACCW
Sequence: MDGTLFPGDDDLAIPATEFFSTKAAKKPEAKREAIVKADEDDNEETLKQRLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTGRRPYE
What is the function of this protein?
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV).  The wrapping consists of the addition of Golgi membranes to the mature virion.  Participates in mature virion (MV) movement within the infected cell.  May play an indirect role in MV-cell fusion.
What are the official names of this protein?
Protein OPG154.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG154 protein family.
Protein: SF3B5_BOVIN
Sequence: MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome.  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
Splicing factor 3B subunit 5, SF3b5, Pre-mRNA-splicing factor SF3b 10 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SF3B5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTPA2_USTMA
Sequence: MPPAALQATVSESVKDAIISKLRQPPSAVPSREWSAETRTSLTPADAGIAEARASAEDIELVDLQHHNFSEPRKRIVSPASLSRFEHSQAFAEILAFICVCNTRVVGKTLTEEIQISSACRTILEMLDQVAALRESTPPDASIGSSRFGNPAFRTFYAKIRENTDRLHRMIPGLETDSEWSRAARAELSVYFQECWGNEKRIDYGSGMELNMACWLLCLCKLRILRLPEDGACIVLRIFWTYVQVMRDIQSSYWLEPAGSHGVWGLDDYHFLPFLWGAGQLSSHRHLRPKAIHDAEIVDEFAPKYMYLACIQFINSVKTASLRWHSPMLDDISGAKSWSKVNQGMIKMYRAEVLKKLPIAQHIFFGSLLRFPEPATGELEEEDVEEDAHGHIHPAGKPHAHGTGEGQAAGWGDCCGIPIPSAFAAAEQEKKRQQGNFSSTMLGEKPFGTGVRRIPFD
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase.  Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A activator 2, Peptidyl-prolyl cis-trans isomerase PTPA-2, PPIase PTPA-2, Rotamase PTPA-2, Phosphotyrosyl phosphatase activator 2.
What is the protein family that this protein belongs to?
Belongs to the PTPA-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G7AC_BREDI
Sequence: MLRVLHRAASALVMATVIGLAPGVAFALAEPTSTPQAPIAAYKPRSNEILWDGYGVPHIYGVDAPSAFYGYGWAQARSHGDNILRLYGEARGKGAEYWGPDYEQTTVWLLTNGVPERAQQWYAQQSPDFRANLDAFAAGINAYAQQNPDDISPEVRQVLPVSGADVVAHAHRLMNFLYVASPGRTLGEGDPPDLADQGSNSWAVAPGKTANGNALLLQNPHLSWTTDYFTYYEAHLVTPDFEIYGATQIGLPVIRFAFNQRMGITNTVNGMVGATNYRLTLQDGGYLYDGQVRPFERRQASYRLRQADGSTVDKPLEIRSSVHGPVFERADGTAVAVRVAGLDRPGMLEQYFDMITAHSFDDYEAAMARMQVPTFNIVYADREGTINYSFNGVAPKRAEGDIAFWQGNVPGDSSRYLWTETHPLDDLPRVTNPPGGFVQNSNDPPWTPTWPVTYTPRDHPSYLAPQTPHSLRAQQSVRLMSENDDLTLERFMALQFSHRAVMADRTLPDLIPAALIDPDPEVQAAARLLAAWDREFTSDSRAALLFEEWARLFAGQNFAGQAAFATPWSLDKPVSTPYGVRDPKAAVDQLRTAIANTKRKYGAIDRPFGDASRMILNDVNVPGAAGYGNLGSFRVFTWSDPDENGIRTPVHGETWVAMIEFSTPVRAYGLMSYGNSRQPGTTHYSDQIERVSRADFRELLLRREQVEAAVQERTPFNFKP
What is the function of this protein?
Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).  Cannot efficiently use cephalosporin C (CPC), penicillin G, or ampicillin as substrates.
What are the official names of this protein?
Glutaryl-7-aminocephalosporanic-acid acylase, Glutaryl-7-ACA acylase, 7-beta-(4-carboxybutanamido)cephalosporanic acid acylase, CAD, GL-7-ACA acylase, GCA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S45 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ERD22_DANRE
Sequence: MNIFRLTGDLSHLAAIIILLLKIWKSRSCAGISGKSQILFALVFTTRYLDLLTSFISLYNTCMKVIYIGCAYATVYLIYAKFRATYDGNHDTFRAEFLVVPVGGLAFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFCLGVYRALYLFNWIWRFYFEGFFDMIAIVAGVVQTILYCDFFYLYVTKVLKGKKLSLPA
What is the function of this protein?
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity).  Binding is pH dependent, and is optimal at pH 5-5. 4 (By similarity).
What are the official names of this protein?
ER lumen protein-retaining receptor 2, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Protein: TPCD_COCH5
Sequence: MQLLGTLSWLYAIQASIGSSKAVTADYGSCHDACTLLSGTLSVELGGSHVSDYKHYPTIANGSSVASLFWAQQQQSAQPACLVHVYSPQDVATVISVSRSTNCPFAVRGGGHSDIPGASNINGGITVNMAALSNVELHESEGLARVGAGARWGDVYKELEKSNKTVVGGRLTGVGVGGLVLGGGLSHFSGLHGWACDNVRNYEVVLANGTLVIASNSSNPDLYRALRGGGNSFGVVTRFDLDVFQQGPMWGGLHVWPFQPSVTSAITRGFVEFAHNAPSDPHVSLFAGLGYKQGGFAWAVGQYDALGRVEPPIFTQFKDDVEVYGTAKIVSTARLTSLSDLADELNQSEPAGIRSRFTTATFTADAELLILIVEFFEEQVQKALDKGLDKDQRFAPMLGIQPLTQNLLRAQETRGGNVMGLRDLDAPLVVCSFGWEWSYESDDKVVIDGIKAVLDHSVSAAKEKGLYHPFKYMNYAALDQDPIESYGKENIEFLKRVRAMYDPEGVFTNLVPGGHKIN
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of terpestacin (PubMed:29185768).  The bifunctional terpene synthase tpcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene preterpestacin I (PubMed:29185768).  The C-terminal prenyltransferase (PT) domain of tpcA catalyzes formation of GFPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP into preterpestacin I (PubMed:29185768).  The cytochrome P450 monooxygenase tpcB then hydroxylates preterpestacin I to yield 24-hydroxypreterpstacin I (renamed as preterpestacin II) whereas the cytochrome P450 monooxygenase tpcC further hydroxylates preterpestacin II to yield 16,17-dihydroxypreterpestacin II (renamed as preterpestacin III) (PubMed:29417814).  Finally, the FAD-dependent monooxygenase tpcD converts preterpestacin III into terpestacin (PubMed:29417814).
What are the official names of this protein?
FAD-dependent monooxygenase tpcD, Terpestacin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: RS15_STRP7
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIKQHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: UREG_METNO
Sequence: MTTSRHGPLRVGIGGPVGSGKTALMEGLCKALRARYDLCAITNDIYTKEDARLLTVAGALPEERIMGVETGGCPHTAIREDASINLAAVAEMRRRFPALDLILIESGGDNLAATFSPELADLTLYVIDVAGGEKIPRKGGPGITRSDLLVINKTDLAPLVGADLAVMEADTRRMRGSRPYVFTSLRQGEGVEEVARFVVEAGGL
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFD1_SCHPO
Sequence: MQNLASQIQEKAVDSQQQLRTIMVQIAAKERALKISELAKKELEDVGEDKAVYTSLGKMFMKSDLASVRTHLDAEMASLREDIEALQKKQTYHETTASNAEQHLQKIKESIS
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
What are the official names of this protein?
Probable prefoldin subunit 1.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
Protein: YXLF_BACSU
Sequence: MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTLQMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKRKCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDPTGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQTNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVTRFEQKTESLEDVYLKVVHA
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YxlF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: PG042_VACCC
Sequence: MNPDNTIAVITETIPIGMQFDKVYLSTFNMWREILSNTTKTLDISSFYWSLSDEVGTNFGTIILNEIVQLPKRGVRVRVAVNKSNKPLKDVERLQMAGVEVRYIDITNILGGVLHTKFWISDNTHIYLGSANMDWRSLTQVKELGIAIFNNRNLAADLTQIFEVYWYLGVNNLPYNWKNFYPSYYNTDHPLSINVSGVPHSVFIASAPQQLCTMERTNDLTALLSCIRNASKFVYVSVMNFIPIIYSKAGKILFWPYIEDELRRSAIDRQVSVKLLISCWQRSSFIMRNFLRSIAMLKSKNIDIEVKLFIVPDADPPIPYSRVNHAKYMVTDKTAYIGTSNWTGNYFTDTCGASINITPDDGLGLRQQLEDIFMRDWNSKYSYELYDTSPTKRCKLLKNMKQCTNDIYCDEIQPEKEIPEYSLE
What is the function of this protein?
DNA nicking enzyme that cleaves extruded cruciform DNA at its tip.  Probably nicks viral hairpins.
What are the official names of this protein?
Virion nicking-joining enzyme, Phospholipase-D-like protein K4.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG042 family.
Protein: RAB25_HUMAN
Sequence: MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL
What is the function of this protein?
Involved in the regulation of cell survival.  Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226).  Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity).  May selectively regulate the apical recycling pathway.  Together with MYO5B regulates transcytosis (By similarity).
What are the official names of this protein?
Ras-related protein Rab-25, CATX-8.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.