PharMolix/UniProtQA huggingface dataset:
Protein: DADA_YERPE
Sequence: MRVVILGSGVVGVTSAWYLAKEGHDVTVIDRQDGPAQETSAGNAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAIRLDGSSLQLRWMWQMLRNCDTSHYMVNKSRMVRLAEYSRDCLKDLRAATGIQYEGRQGGTLQLFRTEQQFDNAAKDIAVLDDAGVPYSLLTAEQLATVEPALAKVAHKLTGGLRLPNDETGDCKLFTERLAKMAEQAGVKFIFNRSVDKLLVEGDQIAGVLCGDDIIKADAYVVAFGAYSTALLAGLVSIPVYPLKGYSLTIPITDPASAPFSTVLDETYKIAITRFDDRIRVGGMAEIVGFNTQLAPARRETLEMVVRDLYPHGGDISQAVFWSGLRPMTPDGTPIVGRTPLKNLYLNTGHGTLGWTMACGSGQLLADIIQGRRPAIVADDLSVARYRAGFQPLNIAPLHDIHPIR
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: FOSB_BREBN
Sequence: MPQLQGLNHLLFSVSDLEKSFCFYRDVLHAKPLVRGRKLAYFDLNGYWLALNEEPDIPRNEIAHSYTHMAFTITEESFDEWYAHLEKHGVTILHGRDRSERDKRSIYFIDPDGHKFELHTGTLQDRLAYYRDEKHHMTFFE
What is the function of this protein?
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin.  L-cysteine is probably the physiological thiol donor.
What are the official names of this protein?
Metallothiol transferase FosB, Fosfomycin resistance protein.
What is the protein family that this protein belongs to?
Belongs to the fosfomycin resistance protein family. FosB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPYR_COREF
Sequence: MSVEVTVEIPKGSRNKYEIDHETGKVYLDRYLFTPMAYPLDYGFIDHTLGEDGDPMDALVILPESVFPNVIVKSRVIGVFKMTDEAGGDDKLLAVLDDPRYDHIQDISDVSDFLKDEIEHFFVHYKDLEKGKHVDGSGWGDKAEAEQILADSIERYKA
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EZH2_XENTR
Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECSVTSDLDFPKQVIPLKTLTAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALAQYSDYEDDEDGDDNQDDERDDTAKDQDDNMEDQETQPLRKFPSDKIFEAISSMFPDKGTLEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNNEAANDGKPCGPHCYQLLEGAREFAAALTAERIKTPPKRPSGRRRGRLPNNTSRPSTPTVNVLEAKDTDSDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVIAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.  May regulate the circadian clock via histone methylation at the promoter of the circadian genes.
What are the official names of this protein?
Histone-lysine N-methyltransferase EZH2, Enhancer of zeste homolog 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3551_METAC
Sequence: MIILETRGLKYTYPDGTVALQGINIEIKKGKKIAFVGQNGSGKSTLFLLLNGTLKPQEGEILFHGSPFKYDSKSLREIRKSVGIVFQNSDDQIFAPTVYQDVAFGPANLGYSKERIDASVQHALEHVGLTRLKDKPPHHLSGGQKKRVAIAGVMAMEPEVIILDEPLSNLDPVGADEIMDLLNEFNHFGSTIIISTHDVDLAYRWSDYVYLMSNSKLIGQGTPAEVFKEQELLKKAGLRQPTTLEIYHEIERRGLAYGKNSPKTIPELVNTLKPLDLMWVEVPPGVREGENLNIGVMYGEYATQSPYEAINATVLHIHPDGRAIVELKRKGIKAGGVLLYDMDSYSLPEVRQIIKDGEIVFVGAMGKQSKTLAEQDGIHLDVTSGVIDKSILMALCGKRCLILTSGGMVDHALNRTREYVEKSGIEFTVGVVNREGGCKWIEEIDENPGALKI
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MA_3551.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y959_STRPC
Sequence: MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTDSVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILYYACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF
What are the official names of this protein?
UPF0758 protein MGAS9429_Spy0959.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: PROFD_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-1, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HUTI_AERS4
Sequence: MNKELLNCERVWLNVTPATLRPDLADYGLLEPHALGVHEGKIHALVPMQDLKGPYPAHWQDMKGKLATPGLIDCHTHLIFAGSRAEEFELRQKGVPYAEIARKGGGILSTVRATRAASEEQLFTLAAARIKSLIREGVTTVEIKSGYGLTLEDELKMLRVARRLGEALPIRVKTTLLAAHAVPPEYRDDPDSWVETICQEIIPAAAEAGLADAVDVFCEHIGFSLAQTEQVYLAADQYGLPVKGHMEQLSNLGGSALAANFGALSVDHLEHLDQEGIQALAHRGVVATLLPTAFYFLKETKLPPVAALRKAHVPMAVSSDINPGTAPIVSLRMAMNMACTLFGLTPVEAMVGVTRNAARALGEQERLGQLRVGMLADFLVWNCAHPAELSYLIGVDQLVSRVVNGEETLHG
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1233_METJA
Sequence: MSKITLVLTMNYITSKIAKEILNSQSEEIFLNLDLNKTEKKEKILIDREKKIAKFPEGDVSFDILKKIAKDEGHIYFIKDGEVFKAAISNNGYYKLVPTIPPTIEINGIRMHRTKEVNPYEDTLNKINAVKVKKGEKVLDTCMGLGYTAIEAYRRGAEVITIEKNPNVLELAKINPYSEELFKGGIKIILGDAYDVIKRFKDEEFDVVIHDPPRFSLAGHLYSEEFYKEIFRVLKPGGRLFHYVGNPGKKYRGKDLQKGVMERLRKVGFVNVKRVEEALGVVAVKPRD
What are the official names of this protein?
Uncharacterized protein MJ1233.
Protein: PYRG_PARXL
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEVGGTVGDIESLPFLEAARQMSLRMGRNSACFVHLTLVPWVATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDERAKISMFSNVPEDAVISVWDADSIYKIPQMLHDQGLDAIICEELKLEPKAADLSMWSDLVEKLEHPRHEVTIGMVGKYVDLTESYKSLIEALRHASMHTSTKVNIEYIDSEEIETHGVESLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKDANSTEFDQETPNRVVALITEWYDREGRVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFVPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALAHQQSRTAAEVGEKA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NACB_ASPOR
Sequence: MLNRSPSGTAFDHENGKLTHTYPQCIISPSSSHTRSTPNSYKPDHESTRLTNSLKNRGKGTPRRKVKKVHKSSGADDKKLQATLKKMNVQPIQAIEEVNMFKEDGNVIHFGAPKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKNQAGAEGKKDDDEDDIPDLVEGENFESNVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: SSDH2_SCHPO
Sequence: MAPQFKRPELFGFDKSHAQSFVQGKWISSPNNKTFEVDNPATGEIIGKVADVSVEETKKAISAANEAFKTYKNFTHVQRSQLLERWAELIMENKDDLVKMLTLENGKPLSQAEMEVTTCSGYLKWYAAEAVRTFGDVAPSSLQSQNFLISIKQPVGVSALITPWNFPAAMIARKGGAALAAGCTAIFLPAFRTPYVCLGLVRLAQEAGFPDGVLNVITSSDASAHGKELTTNPIVRKVSFTGSTNVGKILMGQSASTIKKVSMELGGNAPFIVFPDFPIDQAVESFCTIKFNSCGQVCVCPNRVYVHKNVYDEFVSKLTEKVKTIKVGDGFDSSSAVGPLISQDGCKKVSKHIEDAVSKGAKITVGGKEISSSKGYFFEPTVLSGVTQDMLVASEETFGPLASVFKFDDTEEVIEWANDSDVGLAGYVFTNNLSTMIHVAKELEVGLVGANIEMVDEPFISFGGIKQSGFGKEAGRLGVQEFMVVKEINLKTL
What are the official names of this protein?
Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)], SSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: MTAP_AEDAE
Sequence: MRPAIKIGIIGGSGLDDSQILESRSEKVVSTHFGNPSDVLIEGKIAGVDCVLLARHGRNHSIMPSNVNYRANIWALKTVGCTHVIVSTATGSLQERIHPGDLVIPDNFIDRTTKRAQTFYDGNDMLVGVCHVPMEPAFCSRTREVLIETAKELGLVGVHNKGTVVTIEGPRFSSKAESNLFRQWGADLVNMTLVPEVVLAKEAGLCYAAIAMATDYDCWRDCGENVNVADVMATFKKNVTKVTQLITAVIPKIAEMDWTETIGELTKTVNGSIMLPHAY
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: STHA_KLEP3
Sequence: MSHSWDYDAIVIGSGPGGEGAAMGLVKQGVRVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFVDEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHHPRIYDSDSILSLQHEPRHVIIYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQTALPHIYAVGDVIGYPSLASAAYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_KINRD
Sequence: MLVAAFAAAGEEVEGNPTYPILPHLGELIVGIIFAIIIYAVIAKKVVPRLEAMYEERRAAIEGNVEKAEKAQAEAQVALEQYKAQLADARGEANRIREEARQQGAQILAEMREQAQAESERITTAARATIEAERVQATAQLRAEVGRLATDLAGRIVGESLQDSARQSGVVDRFLADLERSESGASSR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: VAMP5_RAT
Sequence: MAGKELERCQRQADQVTEIMLNNFDKVLERDGKLSELQQRSDQLLDMSSAFSKTTKTLAQQKRWENIRCRVYLGLAVAGGLLLILVVLLVIFLPSGEDSSKP
What is the function of this protein?
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
What are the official names of this protein?
Vesicle-associated membrane protein 5, VAMP-5, Myobrevin.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).
Protein: EFTU_THENN
Sequence: MAKEKFVRTKPHVNVGTIGHIDHGKSTLTAAITKYLSLKGLAQYVPYDQIDKAPEEKARGITINITHVEYETEKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVEVPYMIVFINKTDMVDDPELIELVEMEVRDLLSQYEYPGDEVPVIKGSALKALEAPDDPNHEAYKPIQELLDAMDNYIPDPQRDVDKPFLMPIEDVFSITGRGTVVTGRIERGRIRPGDEVEIIGLSYEIRKTVVTSVEMFRKELDEGIAGDNVGCLLRGIDKDEVERGQVLAAPGSIKPHKRFKAEVYVLKKEEGGRHTPFTKGYKPQFYIRTADVTGEIVGLPEGVEMVMPGDHVEMEIELIYPVAIEKGQRFAIREGGRTVGAGVVTEVIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_SHEHH
Sequence: MFDGIGFMELLLIGIVGLVVLGPERLPTAVRSVSSWIRAMKKMANSVKDELEQELKIEQLHSDLKNAESQGLKNLSPELQDSINQLKEAAQSVNRPYQVEDVPAAKDVPAKEMPTSETSTATNANSDKPNG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: XPA_DROME
Sequence: MSAEVSTNESAPPAEKKSKLTNAQKARIERNQAKAQKLREAKLVSHPFKELASNKEGGTHPEAALSQGSSVIKVQGTKYIDSGGGFLLEQPVMPTGVGPAGLNKSGEEAPPILDDAIAIPVQYEECLECGDMFADSYLFNNFGHSVCDKCRDKDERYALITRTEAKAEYLLKDCDFDKREPKLRYISRKNPHNVRWGEMKLYLHLQIHQRALEVWGSEEELVRQHEAREDKREEGKARKYNKKMKQLRMEVRSSIYTKKTHEVHEHEFGPDTYDEEEDTYTHTCITCPYSETYEKM
What is the function of this protein?
Involved in DNA excision repair.  Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
What are the official names of this protein?
DNA repair protein complementing XP-A cells homolog, Xeroderma pigmentosum group A-complementing protein homolog.
What is the protein family that this protein belongs to?
Belongs to the XPA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_BIFLD
Sequence: MLDIQFIREHTDIVKESQRKRGESVELVDEVLSSDTARREALKAFEEARAQQKEIGKKVASAPADEKAKLIAETKELSQKVSEYKSKADSAAEEYTTAMWKLSNIVEPEAPEGGEDDYVVVKKVGQIRDFAAEGFEPKDHLTLGTGVAGIDMRRGVKVGGSRFYFLRGQVARMQIAMLTMAVDQAEEHGFTLAITPTLVRPEVMRGTGFLNSHADEIYRLREPDDQYLVGTSEVALAGMHENEILDLGNGPLRYCGWSSCYRREAGAAGKDTSGIIRVHQFDKVEMFVYAKQEDSYKEHEHLLAMEQEMLAKVEVPYRIIDTAAGDLGSSAARKFDCEAWVPTQGRYRELTSTSNCTEYQARRLNIRERMEDGGTRPVSTLNGTLATTRWLVAIMENHQQKDGSIEIPQAMRAYMGGKEVIEPTKWEA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_MYCLE
Sequence: MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: TMEDA_DROSI
Sequence: MARAAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEYEVSDVPGQIIDYIARDTKGHILSQKEHITKGKFSFMSEVYETYEICFISKVPAHQRGVVQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE
What is the function of this protein?
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo.  Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein bai.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL14_ECOSM
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NUOH_KLEP7
Sequence: MSWLTPDLIDILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPRFSDRVIFTLAPVIAFTSLLLAFAIVPVSPTWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNNQAHLWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALIVTLFFGGWNGPWLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLVNLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GET3_MOUSE
Sequence: MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSTQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Guided entry of tail-anchored proteins factor 3, ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Protein: DADA_STRM5
Sequence: MRVLVLGSGVIGTTSAWYLRQAGFEVTVIDRQPGPALETSFANAGQLSFGYTSPWAAPGVPKKAIGWLFEKHAPLAIKPGMDLAQYRWLWQMLRNCTHERYAINKARMVRMSEYSRDCLNELRAQIGIEFEGRDLGTTQLFRTQQQLDASAQDIEILAQYGVPYEVLDRAGIIQAEPALAHVDGLVGALRLPRDQTGDCQLFTRRLAQMCVDAGVEFRFDQDITGLVSDGERITGVHVNGTLETADRFVVALGSYSPALVAPLGMRLPVYPLKGYSLTLPITDPAMAPTSTILDESYKVAVTRFDDRIRVGGMAEVAGFDLSLSQRRRETLELVVSDLYPKGGDLSRAQFWTGLRPATPDGTPVIGATPFRNLYLNTGHGTLGWTMACGSGRYLADLMSARQPQISTEGLDVFRYGQYGHAPQHENRTCVLPAR
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.