PharMolix/UniProtQA huggingface dataset:
Protein: TT30A_XENTR
Sequence: MAARQIKDGEYTATIYKLIKEARYGEAIQILSNELQKQYRSRAGLSLLGYCYYQIQDFVNAADCYEQLIQITPEVEEYKLYYAQSLYKACMYPEAMKATFALDSSAYQSKMLKLQASIRYGEEDISGAKSLVEQMPSEDPESEINMGCLLYKEGHYEEACKKFITAMQVMGYKQDLSYNIALCYYSMKQYAPALKHIADIIERGIREHPELGVGMTTEGIEVRSVGNTLVLHETALIEAFNLKAAIEYQLKNYEAAQEALTDMPPRSEEELDPVTLHNQALMNMDTKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFFKLDELAGMLTEQMRKLTKQVQEARHNRDDEAVKKAVNEYDETLEKYIPVLMAQAKIYWNMENYQMVEKIFRKSVEFCNEHDIWKLNVAHVLFMQDNKYKEAIGFYEPIVKKHYDNILNVSAAVLANLCVSYIMTSQNEEAEELMRKIEKEEEQIAYENPDKKIYHLCIVNLVIGTLYCAKGNYEFGISRVIKSLEPYNKKLGTDTWYHAKRCFLSLLENMSKHMIMLRDDVIAECLQFLEHCEIYGRNIPAVIEQPLEEERMHIGKNTVTYESRQLKALLYEITSWNL
What is the function of this protein?
Required for polyglutamylation of axonemal tubulin.  Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
What are the official names of this protein?
Tetratricopeptide repeat protein 30A, TPR repeat protein 30A.
What is the protein family that this protein belongs to?
Belongs to the TTC30/dfy-1/fleer family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: RS21_CERCA
Sequence: MENDAGESVDLYCPRKCSASNRIIHAKDHASVQLNIVDVDPETGRMTVGSKTYAICGEIRRMGESDDCIVRLAKKDGLITKAF
What are the official names of this protein?
40S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: PROA_SPHAL
Sequence: MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAILAANAEDMAAGQTNGLSGAMLDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNGLELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVILRGGSEAVHSNRALHAAFAAGLVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLDGINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEVRGDRDVAALSPHVESASAGDWDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTEDAATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIATGRLHARGPVALEGLTTYKWLVRGSGQLRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFS_AZOBR
Sequence: MTAQGIYLDNNATTRVDPDVLAEMLPLFTEQFGNPSSMHGFGAAVGGQDRMGAQAGAGAARAAHDSEIVFTSGGTESDNTAILSTLEAYPKKKSIVTSVVEHPAVLALCDYLEKKRGYTVHRIGVDNRGNLDLDAYKRCALGPDVAIVSIMWANNETGTIFPIEELAQLAKAAGAVFHTAVQAVGKIPMNVRHSAVDMLCACGHKLHAPKGVHALYVKRGLRFRPIVRGGHQERSRRAGNGERAGHRRAGGGAHVALMHMTDENTRVKRSRQAGAAILAAVPNCFVTGNPANRLPNTCNVAFEYIEGEAILLLLNEADIAASSGSACTSGSLEPSHVMRAMGVPYTAAHGPTRLSLSRETTEEEIDRVIRVVPGMRTGRSVSPYWSQAAPEGVRPVYS
What is the function of this protein?
Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.
What are the official names of this protein?
Cysteine desulfurase, Nitrogenase metalloclusters biosynthesis protein NifS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
Protein: RBKTP_CUPTR
Sequence: MNASGTFFFVVGPSGAGKDALMDGARAALDDNYVFARRVITRPEGAVGEAHEAVSEAEFARRQRSGEFLVTWDAHDLRYGLPCSLMSELERGRHVVANGSRAVIAELAQRLPRFVVVLVTAPQDVLARRIAARGRESGEQIARRVARTGAALPPEVRCLTVLNDSTLEVGRARFVEALRHGTRVASDGAPASRTNLMAKLRGEPLDQAAYVAVLQDAMAGRYTEAELTEFLVAATRSLDDQEVVALARARTVFTPRIKWDEPIVVDKHSIGGVPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAMETVARVDLAHDDVRRCVAQARACIAWNGRLNHSVVDDVMNAITRPLRLDSRRWAVASILSKKYTAGATHVIVDLPYGPQTKLATRADAEALGAMFEHVGKGLGLHVRALVTDGSRPIGRGIGPALEVRDVRQVLANDPCAPADLREKALRFAGEIIAFDARVGSPAEGLRIATALLSEGKAKAAFDRIAATQGARPEPVAPGAHTCVVSATMQGRVAAIDGLRISGVARAAGAPRELGAGVDLLCTIGAKVESGQPLYRIHAGSDAALAAAAALARAGGECSEAVRIDPD
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: PURA_LACGA
Sequence: MTAIAVVGSQWGDEGKGKITDFLSKDAAMAVRSNGGNNAGHTIEIGDKTFKMRLIPSGIFAAKKGAVIGNGVVINPEVMFGELDNLEKEGIDISGLKISNRAHVIMPYHILQDTYQEEAKGDKKIGTTKNGIGPCYMDKASRIGIRVCDLLERDTFEEKLRTNLAEKNALFTKVYNKPALKFEDIFEKYLEYGQKMKKYVTDTSVVVNDALDKNEKVLFEGAQGVMLDIDEGTYPYVTSSNTISGGIASGIGMGANRLNTVIGVCKAYTTRVGEGPFPTELLDEVGDRIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVAGINALSLNLLDVFSGFDKIKIATAYELDGKKIDYYPASLKELYRCKPVYEELPAWDEDITNVKTWEDLPENAKKFLNRVSELVGVPLVTVSVGPDREQTIVLKNPWEM
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_PHOV8
Sequence: MRKAKPKKRVILPDPVFNDQKVSKFVNHLMYDGKKNTSYEIFYAALETVKTKLPNEEKSALEIWKKALDNVTPQIEVKSRRVGGATFQVPTEIRPDRKESISMKNLILFARKRGGKSMADKLAAEIIDAFNEQGGAYKRKEDMHRMAEANRAFAHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RIBL_METM6
Sequence: MEKKIAVTAGTFDLLHPGHFNTLNFAKKHADELVVIIARDETVKKIKGRSPVIPEEQRKIMIETLKPVDRAVLGSLNDKLEPILEIRPDVIILGPDQTTYQINELKSQLAEHFLYPEVLKVEEYVKCPFHSSYDILKEIVRRWCCKELKV
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: F16PA_HYDCU
Sequence: MKRLDQVLAADGVNAELELVIKDVMVACKDIAYKLGQGELAGILGATEDENVQGETQKMLDVISNDLLKDILVANPYVRGVGSEEEDYTIAGNADGKYLVTFDPLDGSSNIDVNLSVGTIFSVLEAQDDQSGDNQEVFLQNGRKQVAAGYVLYGPSSLLVMTTGNGVNLFTLDTNIGEFVLTKEALQIPEDTAEFAINMSNQRFWEPEMKQYIDDCLLGEEGPLAKRYNMRWVASMVAEVHRILIRGGIFMYPYDNRDPSKAGKLRLMYEGNPMSMIVEQAGGASSTGRMDIMDVAPQGIHDRVPVVLGSKNEVAKVVAYHTK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLL4_RAT
Sequence: MTPGSRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV
What is the function of this protein?
Involved in the Notch signaling pathway as Notch ligand.  Activates NOTCH1 and NOTCH4 (PubMed:25700513).  Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.  Essential for retinal progenitor proliferation.  Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types.  During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).
What are the official names of this protein?
Delta-like protein 4, Drosophila Delta homolog 4, Delta4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RF1_SHEON
Sequence: MKESVIRKLEGLLERNEEVLALLGDASVIADQDRFRALSKEYSQLEEVVAGFKAYQQAQADLESAKEMLEEDDAEMREMAQEEIKAAKVELERLEAELQILLLPKDPNDDTNAFIEIRAGAGGDEAAIFAGDLFRMYSRYAEANRWQLEIMSSNEGEHGGFKEIIVKVSGEGAYGKLKFESGGHRVQRVPETESQGRVHTSAVTVVVMHEVPEAEAISINPADLKVDTFRSSGAGGQHVNKTDSAIRITHIPTGIVVECQDQRSQHKNRAQAMSVLAARIQAVEDEKRRSAEESTRRSLVASGDRSERVRTYNFPQGRVSEHRINLTLYRLNEVMEGDLDAILGPLMQEHQADLLAALADEQG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_PSEA7
Sequence: MSQPLTVECPTCGAPVEWKSDNKYRPFCSDRCKLIDLGAWAAEEHAIPGDTLEDDIFSADLPPREH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: REX_STRA5
Sequence: MDKSIPKATAKRLSLYYRIFKRFNTDGIEKASSKQIADALGIDSATVRRDFSYFGELGRRGFGYDVKKLMNFFAEILNDHSTTNVMLVGCGNIGRALLHYRFHDRNKMQISMAFDLDSNDLVGKTTEDGIPVYGISTINDHLIDSDIETAILTVPSTEAQEVADILVKAGIKGILSFSPVHLTLPKDIIVQYVDLTSELQTLLYFMNQQQ
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ER21B_XENLA
Sequence: MNIFRFLGDISHLSAIIILLLKIWKSRSCAGISGKSQLLFAIVFTTRYLDLFTNFISFYNTSMKVVYVASSYATVWMIYSKFKATYDGNHDTFRVEFLIVPTAILSFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGIYRTLYLFNWIWRYQFEEFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA
What is the function of this protein?
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
What are the official names of this protein?
ER lumen protein-retaining receptor 1-B, KDEL endoplasmic reticulum protein retention receptor 1-B, KDEL receptor 1-B.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Protein: LPAT2_BRAOL
Sequence: MAMAAAAVIVPLGILFFISGLVVNLLQAVCYVLIRPLSKNTYRKINRVVAETLWLELVWIVDWWAGVKIQVFADDETFNRMGKEHALVVCNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYLFLERNWAKDESTLKSGLQRLNDFPRPFWLALFVEGTRFTEAKLKAAQEYAATSQLPVPRNVLIPRTKGFVSAVSNMRSFVPAIYDMTVAIPKTSPPPTMLRLFKGQPSVVHVHIKCHSMKDLPESEDEIAQWCRDQFVAKDALLDKHIAADTFPGQKEQNIDRPIKSLAVVVSWACLLTLGAMKFLHWSNLFSSLKGIALSALGLGIITLCMQILIRSSQSERSTPAKVAPAKPKDKHQSGSSSQTEVEEKQK
What is the function of this protein?
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase 2, Lysophosphatidyl acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: C555_CHLTE
Sequence: MSRFVSAALVGAALLVSGNAFAYDAAAGKATYDASCATCHKTGMMGAPKVGDKAAWAPRIAQGMNTLVSKSIKGYKGTKGMMPAKGGNAKLTDAQVGNAVAYMVGQSK
What is the function of this protein?
This basic c-type monoheme cytochrome has been found exclusively in the green photosynthetic bacteria, although its role in bacterial photosynthesis is not established.  It has an unusually low redox potential compared with mitochondrial cytochrome c.  It is reactive with cytochrome c oxidases but not with reductases.
What are the official names of this protein?
Cytochrome c-555, Cytochrome c555.
Protein: LIPA_RICRO
Sequence: MANLNKRPDWIKVKAPNSTEYYNTKDLIKNLRLNTVCEEAACPNIGECWSKKHTTVMILGSVCTRACRFCNVKTGRPDLLDPYEPQRLAEAVQKLNLKHVVITSVDRDDLEDGGASHFAECISEIRKSSPNTTIEILTPDFLRKEGAAEIIANAKPDVFNHNVETVPSLYKTIRPGARYYNSLSLLHNIKKLSPEIFTKSGMMVGLGEEINEVVQVIDDLREAKVDFLTIGQYLQPTKNHAEVAKYVTPEEFKYLERLAKTKGFLMVSASPLTRSSYHADEDFQKLKENYQQKLVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_PSEPK
Sequence: MSYAVIVTGGKQYKVAEGEFLKIEKLEVATGESVTFDRVLLVANGEEVTIGAPVVAGAKVVAEVVSQGRHDKVRIIKFRRRKHHMKRMGHRQWFTEIKITGIQA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: DLDH1_BACSU
Sequence: MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLGGVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGGVAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYSERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQMSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRRPNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAAEAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSLNETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTLGEITMEAAEVAIGSPIHIVK
What is the function of this protein?
Catalyzes the oxidation of dihydrolipoamide to lipoamide.
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, Dihydrolipoamide dehydrogenase, E3 component of pyruvate complex, S complex, 50 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_PYRSA
Sequence: MRRFSETYGQKKQITFFCSNLSITAVVIEGLLKHKEEYGALERGMDILAEAVSVTLGPKGRNVVLESGKYGPPQIVNDGVTIAKEIELEDHIENTGVALIRQAASKTNDVAGDGTTTATVLAHAMVKQGMKNVRCRSKSIAIKRGIEKATQFVISQIAEYSRPVEDTKSITQVAAISAGNDMEVGQMIADAIEKVGREGVISLEEGKSTVTELELTEGNGWFLKKGFISPYFVTDTDRMETTQENPYILLTDKKISLVQELVPIHLELISKTSRPLLIIAEDVEKEALATLVVNKLRGIVNVVAVRAPGFGDRRKTMLEDIAILTGGQVISEDAGFSLETVQLDMLGQARRITVVKEGTTIIAEGHEREVKARCEQIRRQIEASESSYEREKLQERLAKLAGGVAVIKVGAATETEKDKKLRLEDAINATKAAVEEGIVPGGATLIHFIEDLNDWAEDNLLDDELIGALIVEKALSAPMKRIIENTGISSSIIIEKIKDKDFSIGYNAAQGEIEDMYEIGVIDPAKVTRSAMQNAASIASMILTTECIVVDKKKTCSLETSIYWLVLTNKYFCLDLLRLYFFLKD
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, chloroplastic, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RECX_KLEP3
Sequence: MTEPSSRRSGYARLLDRAIRILAMRDHSEQELRRKLAAPVMSKNGPEALDVTPEELEQVVAWCIENRYLDDHRFVGQFIASRSRKGYGPARIRQELSQKGIARQDVEQAMRECDIDWVSLAREQAQRKYGEPLPSAFTEKVKVQRFLLYRGYLMEDIQEIWRNFAD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_KALTU
Sequence: MASHVVGYPRMGPKRELKFALESFWDGKSSAEDLKKVAADLRSSIWKQMADAGIKYIPSNTFAYYDQVLDTTAMLGAVPARYGFNGGEIGFDLYFSMARGNASLPAMEMTKWFDTNYHYIVPELGPEVKFAYSSHKAVDEYKEAKALGVDTVPVLVGPVSYLLLSKAAKGVEKSFPLLSLLPKILPVYKEVIAELKAAGASTIQFDEPTLVMDLESHQLKAFTDAYADLESTLSGLNVLVETYFADLTPEAYKTLVSLNGVTAFGFDLVRGTKTLDLIKSGFPSGKYLFAGVVDGRNIWANDLAASLATLQSLESIVGKDKLVVSTSCSLLHTAVDLVNETKLDDEIKSWLAFAAQKVLEVNALAKALAGQKDEAFFSANAAALASRKSSPRVTNEAVQKAAAGLKGSDHRRATTVSARLDAQQKKLNLPVLPTTTIGSFPQTVELRRVRREYKAKKISEEEYVKAIKEEISKVVKLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTVNGWVQSYGSRCVKPPIIYGDVSRPKAMTVFWSSLAQSMTSRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIEDEAEDLEKAGINVIQIDEAALREGLPLRKSGHGFYLQWAVHSFRITNVGIQDTTQIHTHMCYSNFNDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPPTEELADRIRKMLAVLESNVLWVNPDCGLKTRKYNEVNPALSNMVYAAKPI
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Pollen allergen Sal k 3, SkMetE, Vitamin-B12-independent methionine synthase.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: UCSI_ACRSP
Sequence: MSPTDMKAVVFYGPHSIAIESRPIPKVQHDKDIVVKVSASGLCGSDLHYFRGHEVVDSAGFIMGHEFVGEVVEAGRAVTTVRPGDKVVSPFTVSCGDCFYCKLQNSSRCVHCQVFGSNGLDGAQAEYVRVPLADSTVVRAPPGLSDDALILMADIFPTGFFGARNAMAGLGAQDPTEAVVVVIGCGPVGLCAIVSALEYRPRVVFAIDSVDSRLGLAEKLGARPLDLKKGVPSIISAVQEVTEGRGADAVVEVVGQGPALRTAYDIIRPFGSISSIGAHHSAMPFSATDGYE
What is the function of this protein?
Medium chain reductase/dehydrogenase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Medium chain reductase/dehydrogenase ucsI, UCS1025A pyrrolizidinone biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: RRAGA_RAT
Sequence: MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
What is the function of this protein?
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.  Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form.  In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB.  Involved in the RCC1/Ran-GTPase pathway.  May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
What are the official names of this protein?
Ras-related GTP-binding protein A, Rag A, RagA.
What is the protein family that this protein belongs to?
Belongs to the GTR/RAG GTP-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lysosome.
Protein: HRCA_BORBR
Sequence: MDDRARALLKALIERYIADGQPVGSRTLSKVFDLSPATIRNVMADLEELGLIHSPHTSAGRVPTPRGYRMFVDSLLAVRAYQFEPAHIGELLPVSEPSRAVNAAAALLSNLTQFAGVVLTPKRTQIFRQIEFIRLSDKRVLLIIVTPEGDVQNRILSAQRDYTEAELLEAGNFFNVHFSGKSFDAVRRTLSTELAQLRDDISRLMQAAVEAGAEAADDGEAVVISGERKLLDVTDIASDMDRLRKMFSLFEKKTDLLQLLDVSSRAQGVQIYIGGDSQLVPMEEVSVITAPYGVDGKVIGTLGVIGPTRMAYERVIPIVDITARLLSNALSHNQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: YAEH_SALTI
Sequence: MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDRGEFFAKSVKFKYPRQRKTVVADGIGQGYKEVQEISPNLRYVIDELDQICQRDRSELDLKRKILDDLRHLESVVANKISEIEADLDKLTRK
What are the official names of this protein?
UPF0325 protein YaeH.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.