PharMolix/UniProtQA huggingface dataset:
Protein: FABH1_BACTN
Sequence: MDKINAVITGVGGYVPDYVLTNDEISKMVDTTDEWIMGRIGIKERHILNEEGLGTSYMARKAAKQLMQRTKSRPDDIDLVIVATTTSDYRFPSTASILCERLGLKNAFAFDMQAVCSGFLYAMETGANFIRSGKYKKIIIVGADKMSSVIDYTDRATCPIFGDGAAAFMLEPTTEEVGIMDSVLRTDGKGLPFLHIKAGGSVCPPSYYSLDHHLHYIYQEGRTVFKYAVANMSDSCEAIIARNHLTKEEVDWVIPHQANQRIITAVAQRLEVPSEKVMVNIERYGNTSAGTLPLCIWDFEKKLKKGDNLIFTAFGAGFAWGAVYVKWGYDPKEDA
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III 1, Beta-ketoacyl-ACP synthase III 1, KAS III 1, 3-oxoacyl-[acyl-carrier-protein] synthase 3 1, 3-oxoacyl-[acyl-carrier-protein] synthase III 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPAT1_BOVIN
Sequence: MDESALTLGTIDVSYLPNSSEYSIGRCKHATEEWGECGSRPTVFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAGELNPDGSAQQQSKAVNKVKKKARKILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLIFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDILYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKISCARAGLLSVVVDTLSTNTIPDILIIPGGISYDRIIEGHYNGEQLGKPKKNESLWSIARGVIRMLRKNYGCVKTDFAQPFSLKEYLESQSQKPVSAPLSLEQALLPAILPSRPSGAADEGTDMSINESRNATDESRRRLIAHLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIGLFTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQFLGNCITITHTSKNDEFFITPSTTIPSVFELNFYSNGVLHVFIMEAIIACSLYAVLKKRGPGGPASPSLVSQEQLVHKAASLCYLLSNEGTISLPCQTFYQICHETVGRFIQYGILIVAEQDDQEDISPGLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAVFIHNFGGPVPEPEFLQKLHKYLITRTERRVAVYAESATYCLVKNAVKTFKDIGVFKETKQKRVSGLELSNTFLPQCNRQKLLEYILSLVVL
What is the function of this protein?
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: CY550_CYAPA
Sequence: MFNKNFWTSIIIGCLFCTITYSGVNAAALDEETRTVALNSTETVVLTPEQVKRGKRLFNSTCGICHVGGITKTNPNVGLDSEALALATPPRNNIESLVDYMKNPTSYDGSEEIYDIHPSIRSADAFPKMRNLTEEDLYDIAGHILLSPKILPSQWGGGKIYY
What is the function of this protein?
Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.
What are the official names of this protein?
Cytochrome c-550, Cytochrome c550.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PsbV subfamily.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: SPTSA_HUMAN
Sequence: MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSIVGMALYTGYVFMPQHIMAILHYFEIVQ
What is the function of this protein?
Stimulates the activity of serine palmitoyltransferase (SPT).  The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.  The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851).  Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI) (PubMed:23510452).
What are the official names of this protein?
Serine palmitoyltransferase small subunit A, Small subunit of serine palmitoyltransferase A, ssSPTa.
What is the protein family that this protein belongs to?
Belongs to the SPTSS family. SPTSSA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LOLD_BARHE
Sequence: MTAILELVEIERHFLGGNKPLIILDKANFILNRGELVALVAPSGAGKSTLLHIAGLLEKPTAGDVMLRGVSCAKRSDNERTAIRQNDIGFVYQFHHLLPEFTALENVMIPQMIAGFKKSIAEERALKLLTYLRVSHRANHRPSELSGGEQQRVAIARAVANGPSVLLADEPTGNLDPVTSAYVFQALSALVRQAGLSALIATHNYALAKQMHRRITLKEQKIVELP
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FUT3_HUMAN
Sequence: MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLWTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADTVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:12668675, PubMed:1977660, PubMed:11058871).  Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:12668675, PubMed:11058871, PubMed:27453266).  Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871, PubMed:29593094).  Prefers type 1 chain over type 2 acceptors (PubMed:7721776).  Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776).  Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660).
What are the official names of this protein?
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, Alpha-3-fucosyltransferase FUT3, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: CYC6_NOSS1
Sequence: MKKIFSLVLLGIALFTFAFSSPALAADSVNGAKIFSANCASCHAGGKNLVQAQKTLKKADLEKYGMYSAEAIIAQVTNGKNAMPAFKGRLKPEQIEDVAAYVLGKADADWK
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid lumen.
Protein: NADA_VIBC3
Sequence: MSHILDTINTVYPFPPKPIPLRDEEKQAYIAEIKQLLIEKDAVLIAHYYTDPEIQALAESTGGFVGDSLEMAKFGNRYPATTLIIAGVRFMGESAKILTPEKRILMPTLEAECSLDLGCPADKFTEFCDAHPDHTVVVYANTSAAVKARADWVVTSSIALEIVEHLDSEGKPIIWGPDRHLGAYIAKKTGADMLLWQGECVVHDEFSADALRKMKALYPDAAILVHPESPASVVELADAVGSTSQLIKAAKTLPQQKMIVATDKGIFFKMQQMVPEKELIEAPTAGAGATCRSCAHCPWMAMNGLQAIAQALREGGKQHEIFVDEALRVKSLIPLNRMLDFAEQLNLKVKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHP_BACTI
Sequence: MEKIFKVTSDSGIHARPATLLVNTASKFGSDINLEYNGKNVNLKSIMGVMSLGIQQNAEIKITANGDDAAQALAAIEETMKNEGLGE
What is the function of this protein?
P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes.  Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources.  P-Ser-HPr mediates glucose catabolite repression of cry4A toxin expression.
What are the official names of this protein?
Phosphocarrier protein HPr.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P_OGAPD
Sequence: MTANVGINGFGRIGRLVLRIALSRDDINVIAINDPFIAPDYAAYMFKYDSTHGKFKGTVTHEGKYLVINGKKIEVFQERDPANIPWGKEGVDYVLDSTGVFTTIEGAQKHIDAGAKKVIITAPSKDAPMFVVGVNHEEYTPDIKILSNASCTTNCLAPLAKVINDTYGIEEGLMTTIHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPALAGKLTGMSMRVPTTDVSVVDLTVNLKKPTTYEDICATMKKAAEGPLAGILGYTDEAVVSSDFLTDSRSSVFDAKAGILLTPTFVKLVSWYDNEYGYSTRVVDLLQHVAKVSA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1877_MYCTU
Sequence: MAGPTAPTTAPTAIRAGGPLLSPVRRNIIFTALVFGVLVAATGQTIVVPALPTIVAELGSTVDQSWAVTSYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLAISRALQGVGAGAISVTAYALAAEVVPLRDRGRYQGVLGAVFGVNTVTGPLLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGILVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAAAAILPPRLFGSPVFAVCCVLSFVVGFAMLGALTFVPIYLGYVDGASATASGLRTLPMVIGLLIASTGTGVLVGRTGRYKIFPVAGMALMAVAFLLMSQMDEWTPPLLQSLYLVVLGAGIGLSMQVLVLIVQNTSSFEDLGVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALTSGAVPVPAVPSPAVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLTDIHDDADDLGDGFGVPRAESPEDVLEIAVRRMLPNGVRLRDIATQPGCGLGVAELWALLRIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDILTLTPSGHRQVDSLAVLIRQWLLDHLAVAPGLKRQPDHQFEAALQHVTDAVLVQRDWYEDLGDLSESRQLAATT
What are the official names of this protein?
Uncharacterized MFS-type transporter Rv1877.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YABA_BACLD
Sequence: MDKKELFDTVISLEEQIGSLYRQLGDLKQHIGEMIEENNHLQLENEHLRKRLEETDQRLKSVKSDEKEIKAEKTGHADIGEGHDNLARLYQEGFHICNIHYGSVRKEGDCLFCLSFLNKK
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: Y190_CLOPE
Sequence: MKKGNVRTLDGIIYSLFIFMTIVTLFIIYRDIPSNAVLNFVTAYAIFAILIPLYILVRVLFTVKHFTFEEVKKEGVKFLMFFIGIMMLNLVGDFLLPLPDLKLSKMLPSSLGFAFGITCFDIVLSKRTK
What are the official names of this protein?
Uncharacterized protein CPE0190, ORFC.
Protein: AB13C_ORYSJ
Sequence: MPHFPNLPLPEAAAAAAHAALLALALLLLLLRSARALASRCASCLKTAPRRAAAVDGGLAAASSVGAWYRAALACCGYALLAQVAALSYEVAVAGSHVAVEALLLPAVQALAWAALLALAMQARAVGWGRFPVLVRVWWVVSFVLCVGIAYDDTRHLMGDDDDDEVDYAHMVANFASAPALGFLCLVGVMGSTGVELEFTDDDSSVHEPLLLGGQRRDADEEPGCLRVTPYGDAGIVSLATLSWLSPLLSVGAQRPLELADIPLMAHKDRAKSCYKAMSSHYERQRMERPGSEPSLAWAILKSFWREAAINGAFAAVNTIVSYVGPYLISYFVDYLSGKIEFPHEGYILASVFFVAKLLETLTARQWYLGVDVMGIHVKSGLTAMVYRKGLRLSNSSRQSHTSGEIVNYMAVDVQRVGDYAWYFHDIWMLPLQIILALAILYKNVGIAMVSTLVATVLSIAASVPVAKLQEHYQDKLMASKDERMRKTSECLKNMRILKLQAWEDRYRLKLEEMRNVECKWLRWALYSQAAVTFVFWSSPIFVAVITFGTCILLGGELTAGGVLSALATFRILQEPLRNFPDLISMIAQTRVSLDRLSHFLQQEELPDDATITVPHGSTDKAININDATFSWNPSSPTPTLSGINLSVVRGMRVAVCGVIGSGKSSLLSSILGEIPKLCGQVRISGSAAYVPQTAWIQSGNIEENILFGSPMDKQRYKRVIEACSLKKDLQLLQYGDQTIIGDRGINLSGGQKQRVQLARALYQDADIYLLDDPFSAVDAHTGSELFREYILTALASKTVIYVTHQIEFLPAADLILVLKDGHITQAGKYDDLLQAGTDFNALVCAHKEAIETMEFSEDSDEDTVSSVPIKRLTPSVSNIDNLKNKVSNNEKPSSTRGIKEKKKKPEERKKKRSVQEEERERGRVSLQVYLSYMGEAYKGTLIPLIILAQTMFQVLQIASNWWMAWANPQTEGDAPKTDSVVLLVVYMSLAFGSSLFVFVRSLLVATFGLATAQKLFVKMLRCVFRAPMSFFDTTPSGRILNRVSVDQSVVDLDIAFRLGGFASTTIQLLGIVAVMSKVTWQVLILIVPMAVACMWMQRYYIASSRELTRILSVQKSPVIHLFSESIAGAATIRGFGQEKRFMKRNLYLLDCFARPLFSSLAAIEWLCLRMELLSTFVFAFCMAILVSFPPGTIEPSMAGLAVTYGLNLNARMSRWILSFCKLENRIISVERIYQYCKLPSEAPLIIENSRPSSSWPENGNIELVDLKVRYKDDLPLVLHGISCIFPGGKKIGIVGRTGSGKSTLIQALFRLIEPTGGKVIIDDVDISRIGLHDLRSRLSIIPQDPTLFEGTIRMNLDPLEECTDQEIWEALEKCQLGEVIRSKDEKLDSPVLENGDNWSVGQRQLIALGRALLKQAKILVLDEATASVDTATDNLIQKIIRSEFKDCTVCTIAHRIPTVIDSDLVLVLSDGKIAEFDTPQRLLEDKSSMFMQLVSEYSTRSSCI
What is the function of this protein?
ABC transporter that may affect phytic acid transport and compartmentalization.  May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking.  Required for phytic acid accumulation in developing seeds.  Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
What are the official names of this protein?
ABC transporter C family member 13, OsABCC13, Multidrug resistance-associated protein 13, OsMRP13, OsMRP5, Protein LOW PHYTIC ACID 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UBIA_ECOUT
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGIFQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FABZ_CAMJR
Sequence: MIDVMQIQEILPHRYPFLLVDKITELKVKEVVLGYKNISISDHVFMGHFPGHPIYPGVLILEGMAQTGGVLAFESMEDKVDPKSKVVYFTGIDGAKFRNPVRPGDRLDYEMSVVKNRGNMWIFKGQAFVDGNLVAEAELKAMIVDK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGDA_ACIFV
Sequence: MPKTVSPGVQALRDVVEKVYRELREAKERGEKVGWSSSKFPCELAESFGLHVGYPENQAAGIAANRDGEVMCQAAEDIGYDNDICGYARISLAYAAGFRGANKMDKDGNYVINPHSGKQMKDANGKKVFDADGKPVIDPKTLKPFATTDNIYEIAALPEGEEKTRRQNALHKYRQMTMPMPDFVLCCNNICNCMTKWYEDIARRHNIPLIMIDVPYNEFDHVNEANVKYIRSQLDTAIRQMEEITGKKFDEDKFEQCCQNANRTAKAWLKVCDYLQYKPAPFNGFDLFNHMADVVTARGRVEAAEAFELLAKELEQHVKEGTTTAPFKEQHRIMFEGIPCWPKLPNLFKPLKANGLNITGVVYAPAFGFVYNNLDELVKAYCKAPNSVSIEQGVAWREGLIRDNKVDGVLVHYNRSCKPWSGYMPEMQRRFTKDMGIPTAGFDGDQADPRNFNAAQYETRVQGLVEAMEANDEKKGK
What is the function of this protein?
Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway (PubMed:3691501).  Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)-glutaconyl-CoA (PubMed:3691501, PubMed:7398622, PubMed:7607244).  The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical (PubMed:7607244).  Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate (PubMed:7607244).  The appropriate redox state of dehydratase HgdA-HgdB complex (CompD) is maintained by HgdC (CompA) via hydrolysis of ATP and ATP-dependent electron transfer (PubMed:7607244).  Since the electron is recycled, the dehydratase is able to perform several turnovers with only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) (PubMed:7607244).
What are the official names of this protein?
(R)-2-hydroxyglutaryl-CoA dehydratase, subunit alpha, (R)-2-hydroxyglutaryl-CoA dehydratase, component D.
What is the protein family that this protein belongs to?
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_METPB
Sequence: MKKAYVKSYGCQMNAYDAGRMADVLAAEGYSATESVEEADVVVLNTCHIREKAAEKVYSELGRLRVLKGERAESGQDTRIVVAGCVAQAEGREILSRAPAVDVVVGPQSYHRLPDLLRQSRETRVVDTEFPVEDKFDHLPARRNRGVTGFLTVQEGCDKFCAFCVVPYTRGAEVSRSVAAVVEEARRLVEGGVREITLIGQNVNAYHGDGPDGAPATLGHLMDALSAVPGLLRLRYTTSHPNDFADDLIAAHAGNPLVMPYLHLPVQSGSDRILHAMNRRHTGDAYRRLIERIRTARPDIALSSDFIVGFPGESDADFAETMRLVAEIGFAAAFSFKYSPRAGTPAAEREDAVPEAVKTERLAALQQLLDQQRHAFNAAAVGTVAEILVEKTGRHPGQVAGKTPHLQAVQFDAPASTIGTLVPVRITRAGSNSLFGEVLEGAAAAA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_KLEP7
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: WDR55_RAT
Sequence: MDPTCQESPAEDSNNEEDLDSTKAAPRIRDTPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHVLDVEQGQLERRISKAHSAPINSLLLVDENVLVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGEPVEELALSHCGHFLASSGHDQRLKFWDMTQLRTVVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREDEEEAKAPEEVSGESDDDSD
What is the function of this protein?
Nucleolar protein that acts as a modulator of rRNA synthesis.  Plays a central role during organogenesis (By similarity).
What are the official names of this protein?
WD repeat-containing protein 55.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: SYQ_PROMH
Sequence: MNEADARPTNFIRQIIDEDLATGKHNSVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGKCNLRFDDTNPVKEDVEYINSIQKDVQWLGFQWDGNVHYSSDYFDQLYQYAIELINKGLAYVDELSAEEIREYRGTLKEPGKNSPYRSRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALENITHSLCTLEFQDNRRLYDWVLDNITIPCHPRQYEFSRLNLEYTVMSKRKLNQLVTENIVDGWDDPRMPTISGLRRRGYTAESIREFCQRIGVTKQDNNVEMASLEACIRDDLNENAPRAMAVIDPVRLVIENMPEGEEILTAPNHPNKPEMGTREVPFSREIYIDRADFKEEANRQYKRLVLGKEVRLRNAYVIKAERVEKDEQGEITTIYCTYDPQTLNKDPADGRKVKGVIHWVSIPHAIPAEIRLYDRLFSVPNPGAEEDFLSTINPESLVIRQGFVEASLKDAAIEKAYQFEREGYFCADKLSTADKLVFNRTVGLRDTWAKISKQG
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_PROMM
Sequence: MRVDYDVAAALRHEGLKPHDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSFPTSGHRILVGPGENAGVVDLGDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLEDERNVGLMEGVVEGIAHYGNCVGVPTVGGEVAFDSSYSGNPLVNAMALGLMETDEIVCSGAHGVGYPVIYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVGDPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELGMTPYEFLLSESQERMLFVVKPGQEQSLMERFIRWGLQAAIVGCVLEEKVVRVLQKGEVVAEVPANALADDTPIDRHELVSDPPLEIQAKWDWQENLLPVVGLKGINLNSQSHFGSNISWDEILLKLLDDPTIASKRWVYRQYDHQVQANTVSAPGVSDAAVVRLRPQQGKGSVDEVKRGVAAVVDCPNRWVFLDPERGAMAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLALACRGLSKACKTFSTPVTGGNVSLYNETRLADGKIQPIHPTPVVGMVGLVHNLVNVCGQAWLEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVTGRPPEIDLKLECLVQSFLRNSITEGFVRSAHDLSDGGLAVAVAECCIAANLGAHIELPSSDARLDRLLFAEGGSRILVSVPSTQAVAWQKVLNQAKTTAPGSVFDQYLGVVTADDELLITQAGNRLVQLPLNQLRECFEQAIPRRMGLDLSSSV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.