PharMolix/UniProtQA huggingface dataset:
Protein: TMM33_MOUSE
Sequence: MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSFLDKLSTNQQNILKFIACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHIIMKPSCPLFVRRLCLQSIAFISRLAPTVA
What is the function of this protein?
Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis.  Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699).  Suppresses the RTN3/4-induced formation of the ER tubules.  Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.  Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis.  Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.  Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM.  Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity).
What are the official names of this protein?
Transmembrane protein 33, Protein DB83.
What is the protein family that this protein belongs to?
Belongs to the PER33/POM33 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Melanosome. Nucleus envelope. Note=Co-localizes with RTN4 at the ER sheets.
Protein: SYGB_PSEPW
Sequence: MSAQDFLVELGTEELPPKALATLGDAFLAGIEKGLQAAGLNYTGKQVYAAPRRLAVLIRQLDVQQPDRSINIDGPPLQAAFKDGEPTQAALGFAKKCGVELSEIDQSGAKLRFSQHIPGKATASLLPTIVEDSLNDLPIPKRMRWAASREEFVRPTQWLVMLLGDQVVDCTILSQQAGRESRGHRFHHPQNVVITTPANYVEDLRKAYVLADFAERRELIAKRTTELAMQQEGTAIVPPALLDEVTALVEWPVPLVCSFEERFLEVPQEALITTMQDNQKYFCLLDSEGKLLPRFITVANVESRDPKQIVSGNEKVVRPRLTDAEFFFKQDKKQPLETFNERLKNVVFQAQLGTVYDKAERVSRLAAYIAPLIGGDAQRAGRAGLLSKCDLATEMVGEFPEMQGVAGYYYALNDGEPQDVALALNEQYMPRGAGAELPQTLTGAAVAIADKLDTLVGIFGIGMLPTGSKDPYALRRAALGVLRILIEKQLDLDLTPAVEFAVKQFGAKVKAAGLAEQVLEFIFDRLRARYEDEGIDVATYLSVRALKPGSALDFDQRVQAVQAFRKLPEAEALAAVNKRVSNLLSKAEGAIAEQVEPKYFDNANEFSLYSAIQQADQAVQPMAAARQYSESLARLAALRDPVDAFFEAVMVNAEDAKVRANRYALLSRLRGLFLGVADISLLG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANGI_PANTR
Sequence: MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDHRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: CTRA_NEIMA
Sequence: MLKLKFCIVISFLILGSACSAIPSSGPSAKKVVSLGQQSEAQIPEVELIDVNHAVAQSLYKAQVNQSFTQFGDGYASTGTLNIGDVLDIMIWEAPPAVLFGGGLSSMGSGSAQQTKLPEQLVTARGTVSVPFVGDISVVGKTPGQVQEIIKGRLKKMANQPQVMVRLVQNNAANVSVIRAGNSVRMPLTAAGERVLDAVAAVGGSTANVQDTNVQLTRGNVVRTVALEDLVANPRQNILLRRGDVVTMITNPYTFTSMGAVGRTQEIGFSARGLSLSEAIGRMGGLQDRRSDARGVFVFRYTPLVELPAERQDKWIAQGYGSEAEIPTVYRVNMADAHSLFSMQRFPVKNKDVLYVSNAPLAEVQKFLSFVFSPVTSGANSINNLTN
What is the function of this protein?
Involved in transport of capsular polysaccharides to the cell surface.  May function as a membrane anchor for capsular polysaccharides.  Possible porin properties.
What are the official names of this protein?
Capsule polysaccharide export outer membrane protein CtrA.
What is the protein family that this protein belongs to?
Belongs to the BexD/CtrA/VexA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: G6PI_BURM1
Sequence: MTLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITDETLRLLVQLAREARVEARRDAMFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAKMATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVTHALRHVATRDISMHFVSNVDGADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSANPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFREAPLERNLPVLLGLIGIWYRNFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDGRFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEHKVLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED31_CAEEL
Sequence: MGRFSFNRYGYNTMQMESVESEKTRFEVECEFVQALANPNYLNFLAQRGYFKEEYFVNYLKYLLYWKDPQYARCLKFPQCLHMLEALQSQQFRDSMAYGPSAKFVEDQVVLQWQFYLRKRHRLCMMPDEGQELEESEDEADIRQKDTEDEDDEETMKKPDADTAEKNSTTSTVSKKEK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31, Mediator complex subunit 31, Mediator complex subunit soh-1.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4759_ARATH
Sequence: MASRTKTGLMETPRSKPSPPTPRVSKPTVTKSDGNSPSPVQSTRLSIDRSPQTVNSKPVSDRRTARVPTPPEANYFLIIICMAFQKSQSRLGKGTGLLVQQTQEDLRKANEQIERLKKDKAKALDDLKESEKLTKEANEKLREALAAQHHAEKSSEIEKFRAVELEQAGIEAVHKKEVSWKKEVESIRSQHALDISALLSTTEELHRIKQELAMTADAKNKALSHAEEATKIAENQAEKAEILSSELSRLKALVGSDEQKKSNEDDEVVSKLKSEIEMLRGKLEKVSILENTLKDQEESIELLHVDLQAAKMVESYANNLAAEWKNEVDKQVEESKELKTSASESLDLAMKQLEENNHALHEAELGNATLKEKVESLVTTIGRQENDLEESQHQVCISKEETSKLEKLVESIKSDLETTQGEKVRALLNEKTATSQIQNLLSEKTELATELENCKKEEEKIKKAMESLTLDLQEVSVEAKEAKEKLLTCQAELELCGVQIESLKLAEKDTNEKHGKMLEDARNEIDGLKSSLENTENEFFNSKTEWEQRELHLMLCVKKLEDGNFSVQEELSKVKNLLHLKEVEACAAKEEDAKMQTNRKELEEEIKDLQEIVEVAKADSMKLKESLVEKEDELKNTAAENRKLREMEVSSIDKIDQLSKVKESLVDKETKLQNIIQEAEELRVKEIDYLKKIEELSAAKESLVEKETKLLSTVQEAEELRRRELACLKKIEELSAVNERLVDKETKLQSSIQEVEVLKEREAENIKQIEELSLSNERLVEKEAKLQTVVQENEELREKESAYQKKIEELSKVDEIFADREAKLQSSTQENEELREREVAYLKKIEELAKLQENLLDKENELHDMVLEIEDLKAKDSLAEKKIEELSNLNKSLLVKESELQDVVFENEKLKSKEALSLKTTEELSDVKQTLADKEKELKTAVVENEKLKAQAASSFQKIEELKNLKQSLLDKENELEGVFQANEELKAKEASSLKKIDELLHLEQSWIDKGNENQELKVREASAAKRIEELSKMKESLLDKELQTVIHDNYELKAREASALKKIEELSKLLEEASSTHEKGEEITNTNPFDNSTGEQKVQESPLEAIDRHLKDDTTIHWSAHNVQVIGKGEKGKDKDTVESEVYHLEKREASSERDTEHDFAEEEVDSKAEGSENFDQLSNGLSLAEQTEDVVSKDQQQKKKKPLLRKFGNLLKKKSSSQK
What are the official names of this protein?
WEB family protein At4g27595, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the WEB family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UREE_YERRO
Sequence: MILIEHILGNVKKDPVWQAKLKNATFDLLVLDQREAQKSRCRKSSTQGLDLGISLDRHVVLADGDVLAWDEKTNVAVVVQINLRDVMVIDLSELKTRSPDELIKTCFELGHALGNQHWKAVTKNNEVYVPLTVATTMMDSVMRTHGFQHLPFRFVKGAEILPRLSNSEARLLFGGAEDTDTHVHVASPLDEPHGSGLHIHGIHSHGDGHSHSHDDHDHDHNHDHDHKH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_MACCJ
Sequence: MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIAQKKRNKENADDAIKAMREVGEEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDENVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSGARFAFLTKDGARLERALMNFMLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYRDEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALEDMTRSAESILEKLNIPYRTIALCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQARRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQNEDGSITVPEVLVPYMGGQTVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXS1A_CUPSA
Sequence: FLAKKVAKTVAKQAAKQGAKYVVNKQME
What are the official names of this protein?
Short cationic peptide-1a, SCP-1a, Cupiennin 1-like peptide-1a, Truncated variant of Cupiennin 1 family.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP6_WOLWR
Sequence: MALNPLEQFKVYTVIELPRLFGYDVSFTNSSLFMMISVILVILFLLFGIKKGAVIPGYLQAAVEYVYDFVISIIENNTGSKGLQHIPLIFTVFIFILSCNLVGVLPYSFTVTSHVIVTFALSMVVFIYITIVGFKERGVEFLRILLPKGTPSWLAPIIIIIKLFAYLVRPVSLSIRLAANMIAGHTIIKVIAGFIVNMNIFFTPAPFLFIIALIGFEVFVAILQAYIFTILTCVYLSDAVK
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDC3_MAIZE
Sequence: PNEPLRVNVLFKHVQKMLTGDSAVIAETGDSWFNCQKLKLPEGCGYEFQMQYGSIGWSVGALLGYPQGANHKRVIAFIGDGSFQVTAQDVSTILRCEQNSIIFLINNGGYTIEVEIHDGPYNVIKNWNYTGFVDAIHNGLGKCWTSKVKSEEDLTAAIETALGEKDCLCFIEVIAHKDDTSKELLEWGSRVSAANSRPPNPQ
What are the official names of this protein?
Pyruvate decarboxylase 3, PDC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: RL17_STACT
Sequence: MGYRKLGRTSDQRKAMLRDLATSLIVNERIETTEARAKELRGVVDSLITLGKKGDLASRRQAAKVVRDVEILNEDDTTQTALQKLFGEIAPRYTDRQGGYTRVLKAGPRRGDGAESAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ACCA_HELPH
Sequence: MAIYLDFENHIKEIQNEIELALIRGDEDAKEILEKRLDKEVKSIYSNLTDFQKLQLARHPDRPYAMDYIDLILKDKYEVFGDRHYNDDKAIVCFIGKIDNVPVVVIGEEKGRGTKNKLLRNFGMPNPCGYRKALKMAKFAEKFNLPILMLVDTAGAYPGIGAEERGQSEAIAKNLQEFASLKVPTISVIIGEGGSGGALAIAVADKLAMMEYSIFSVISPEGCAAILWDDPSKTEVAIKAMKITPRDLKEAGLIDDIILEPSKGAHRDKFSAANTIKEYFLDALRTIQQDPHFLENRYQKLMSLGSFVESMN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_BORPA
Sequence: MSAVPDIPGGPAQRLAQACDALRLPADAGQQQKLLRYIEQMQRWNRTYNLTAIRDPGQMLVQHLFDSLSVVAPLERGLPAAGSGARVKLFDVGSGGGLPGVVLAIMRAHWDVTCVDAVEKKTAFVRQMAGALGLPNLQAAHTRIEQLEPAQCDVVISRAFASLQDFAKLAGRHVREGGTLVAMKGKVPDDEIQALQQHGHWTVERIEPLVVPALDAQRCLIWMRRSQGNI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_PROM0
Sequence: MLDKEVLVIGAGLAGSEAAWQLANSGVPVKLVEMRPIKSTPAHHTSEFGELVCSNSFGALSPDRAAGLLQKELRFFKSLIVQTADKFAVPAGGALAVDRSKFSYALTEQLSNHPLVEIKRFEQLDIPSEENITILATGPLTADDLSYKIQDFTGIDDCHFFDAASPIIYGDSIDQEIVFKASRYDKGDPAYLNCPMDENKYIHFRNELIEGEQANLKDFEKESANFFEACLPIEEIARRGVDTMRYGPLKSIGLWNPKWGDLFDRENRLKKRPHAVVQLRKEDLEGKLLNMVGFQTNLKWSEQKRIFRMIPGLEKAEFVRFGVMHRNTFLESPKLLLPTLQFMKRENLFAAGQITGTEGYAAAAAGGLLAGINASLLAKGKKPVSFPDESMIGSLMNFISNKNQILSNQKKNKFQPMPASFGLVPELTKRIKDKRLRYKAYQERSTEALNDFKNKLDSCFDKDHLLSKIY
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMGA_BACSU
Sequence: MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLKKRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEESLVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQYAKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRDAETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDLACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIRKGIALGYLTTNNYDRWVYHEKD
What is the function of this protein?
Required for uptake of DNA by competent cells.
What are the official names of this protein?
ComG operon protein 1.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mostly to the cell poles during the development of competence, this depends on comK. During competence a number of proteins (at least CoiA, ComFA, ComGA, DprA, RecA and SsbB) are thought to colocalize at the cell pole, when comFA is disrupted ComGA no longer accumulates (PubMed:16009133). Colocalizes with CoiA and DprA (PubMed:17630974). During development of competence ComGA and SsbB colocalize in discrete foci which accumulate at the cell poles and then delocalize without the overall levels of proteins decreasing, these processes are coincident with the timing of transformability and the site of DNA uptake (PubMed:16009133).
Protein: DAPF_NATTJ
Sequence: MKFEKMHGLGNDFILMKDFQRNYPDLAKRLCDRRFGIGADGLVIYSSCKNSNINADYQMRIYNSDGSEAEMCGNAIRCLAKYLAKTEETDGKRLAIATTAGIKRVEIVENFDLMGEINLSGMVGSQEQLVKVNMEKPLLKSSDIPLAVKNDRNDIARQRPIDTPYGIYYLTEVSTGPPHAVIFVQNLLPEEQLLELGPIIEKHDLFPYGTNVEFVKVESSNHLRVQVWERGAGKTLACGTGACAVVVAATINGFCNGMAYVELPGGKLFINWDNNTEELYMIGPAEHVYSGELNNQIFY
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBCP1_MOUSE
Sequence: MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQKLLGLKVKGKPAENDVKLGALKLKPNTKIMMMGTREESLEDVLCPPPDNDDVINDFDIEDEVVEVENREENLLKVSRRVKEYKVEVLNPPREGKKLLVLDVDYTLFDHRSCAETGVELMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIDVKPLGVIWGKFSEFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELVKLTQYLKEIAKLDDFLELNHKYWERYLSKKQGQ
What is the function of this protein?
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity.  Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1.  Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.  Has also been reported to stimulate the proteolytic activity of the 26S proteasome.
What are the official names of this protein?
Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with nuclear proteasomes.
Protein: DHPS_NEIMB
Sequence: MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: ARPC1_YEAST
Sequence: MSFSNSKDKSVVAVYKLVKAPIYSHCFSQDKSILAVTCETDCLVYRVSNNTPPVLFATLKDHDKTITAVDISIHGRIVTCSQDRNAYVWEPLSDGTYKPTLVLLRINRAATSVTWAPNGYKFAVGSSARIIAVCYYEHENNWWVSKHIKKPIKSTINCLSWHANGVLLAAGGTDGFMRVFSGFIKGLDSKESVAGSPWGQKFPFGCLIREWYQGSYIHDVEWRSQMERIAYVAHDGTLNVVDYQSPVQSVNAPEGLPYRSLVWINDHEIVCGGYSCHPVLFSEASEGWKFAKNLDKSDNNKSSALTASGNTDELSGNNDESSTFGISALRKFKELDLKGKVSTDVQESAHENAIVELRPFAESNGQITQVSSCGLDGKIVIYTI
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 1, Arp2/3 complex 41 kDa subunit, p41-ARC.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ARPC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.
Protein: TRMD_OCEIH
Sequence: MHIDILTLFPEMFHGVFQSSILNKAVERQQFTYDLVNFREYSKNKHQKVDDYPYGGGAGMVLTPQPIFDAVEAVKSKRNSKPRVILMCPQGETLTQQKSEELAKEDHLIFICGHYEGYDERIREHIVTDEISIGDYVLTGGELGSMVVVDSVVRLLPDVLGNQQSAPQDSFSTGLLEHPHYTRPADFRGYKVPEVLLSGNHANIDSWRRKQSLIRTWNRRRDLLDKIELTDEEKITLNTDTPDEV
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_XYLFA
Sequence: MIFPCLFQSMLNLYAEALSTFSLLFEEAKSSSEIEPDAMMLATASLEGHPSVRTVLLKKFDARGFVFYSHIDSPKGRDLQANPQAALLFLWRSLREAGVQVRIEGRVQQVLAEEADAYFASRPRQSQIGAWASMQSCPLGSPEEFQARLAEVKATFEGRDVPRPEGWVGFRVAPRVLEFWYGARFRLHERWRYEVDAAGYWRKFLLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RECF_ECO5E
Sequence: MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEPGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELIPLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRQLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_ECO27
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.