PharMolix/UniProtQA huggingface dataset:
Protein: GLMM_BURO1
Sequence: MGRRYFGTDGIRGTVGEAPITPDFVLRLGYAAGKVLAGSADVAAGSRPTVLIGKDTRVSGYMLEAALEAGFSAAGVDVMLAGPMPTPGVAYLTRALRLSAGVVISASHNPYHDNGIKFFSADGNKLPDDTEAAIEAWLDKPLECAPSDGLGKARRLDDAAGRYIEFCKSTFPAAFDLRGLKLVIDCAHGAAYQIAPHVFHELGADVIPIGVAPNGFNINDGVGATAPDALVRAVRANHADLGIALDGDADRLQVVDATGRLYNGDELLYVLVKDRIATDGKVDGAVGTLMTNLAVEVALQREGVKFVRAAVGDRYVLEQLREHGWQLGAEGSGHILSLDRHSTGDGIVSALLVLAALKRSGRTLAQVLDGVTLFPQKLINVRMKPGADWKGSASIRAAIDAAEAALAGSGRVLIRASGTEPVLRVMVEAQQAADAVRHAETIADAVRAATT
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: SODM2_STAAC
Sequence: MAFKLPNLPYAYDALEPYIDQRTMEFHHDKHHNTYVTKLNATVEGTELEHQSLADMIANLDKVPEAMRMSVRNNGGGHFNHSLFWEILSPNSEEKGGVIDDIKAQWGTLDEFKNEFANKATTLFGSGWTWLVVNDGKLEIVTTPNQDNPLTEGKTPILLFDVWEHAYYLKYQNKRPDYMTAFWNIVNWKKVDELYQAAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe] 2.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: Y896_STRP3
Sequence: MSDEKYNAKLDQAGGKLKEGFGKISGDKSLETEGKVDKVTGKVKEVIADAKDTVKGLAKGLDNKDK
What are the official names of this protein?
UPF0337 protein SpyM3_0896.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: RPOB_YERP3
Sequence: MVYSYTEKKRIRKDFGKRPQVLDIPYLLSIQLDSFQKFIEQDPEGQHGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVKECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNFTTAQILDLFFEKVVFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKARRITARHIRQLEKDGIDRIEVPVEYIAGKVVAKDYVDASTGELICAANMELSLDLLAKLSQAGHKQIETLFTNDLDHGAYISETLRVDPTSDRLSALVEIYRMMRPGEPPTREAAENLFENLFFSEDRYDLSAVGRMKFNRSLLRDEIEGSGILSKEDITEVMKKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRRVRDGVVTDEINYLSAIEEGNFVIAQANSNLDDEGRFLEDLVTCRSKGESSLFSREQVDYMDVSTQQIVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTSVAKRGGTVQYVDASRIVIKVNEDEMHPGEAGIDIYNLTKYTRSNQNTCINQMPCVNLGEPIERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLTEELQILEAGLFARIHAVLVSGGIEAEKLSKLPRERWLELGLTDEDKQNQLEQLAEQYDEMKSEFEKKMDAKRRKITQGDDLAPGVLKIVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGEKINAMLKKQEEVAKLREFIQKAYDLGDNVCQKVDLSTFTDDEVLRLAENLKKGMPIATPVFDGATEKEIKELLQLGGLPTSGQITLFDGRTGEQFERQVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLLKEIRSLGINIELEEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PER9_CAPAN
Sequence: GFDVVDNIK
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 9.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP9_SACPA
Sequence: MQLVLAAKYIGAGISTIGLLGAGIGIAIVFAALINGVSRNPSIKDTVFPMAILGFALSEATGLFCLMVSFLLLFGV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
What are the official names of this protein?
ATP synthase subunit 9, mitochondrial, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ZDS_MAIZE
Sequence: MASVAATTTLAPALAPRRARPGTGLVPPRRASAVAARSTVTSPTWRQRSQRLFPPEPEHYRGPKLKVAIIGAGLAGMSTAVELLDQGHEVDLYESRPFIGGKVGSFVDRQGNHIEMGLHVFFGCYSNLFRLMKKVGADNNLLVKEHTHTFVNKGGTIGELDFRFPVGAPLHGIQAFLRTNQLKVYDKARNAVALALSPVVRALVDPDGALQQVRDLDDISFSDWFMSKGGTRESITRMWDPVRYALGFIDCDNISARCMLTIFTLFATKTEASLLRMLKGSPDVYLSGPIKKYITDRGGRFHLRWGCREVLYEKSPDGETYVKGLLLTKATSREIIKADAYVAACDVPGIKRLLPSEWREWEMFDNIYKLDGVPVVTVQLRYNGWVTELQDLEKSRQLQRAVGLDNLLYTADADFSCFSDLALSSPADYYIEGQGSLIQAVLTPGDPYMPLPNEEIISKVQKQVVELFPSSRGLEVTWSSVVKIGQSLYREAPGNDPFRPDQKTPVKNFFLSGSYTKQDYIDSMEGATLSGRRTSAYICGAGEELLALRKKLLIDDGEKALGNVQVLQAS
What is the function of this protein?
Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene.  It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.
What are the official names of this protein?
Zeta-carotene desaturase, chloroplastic/chromoplastic, 9,9'-di-cis-zeta-carotene desaturase, Carotene 7,8-desaturase.
What is the protein family that this protein belongs to?
Belongs to the zeta carotene desaturase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chromoplast.
Protein: NADK_PARUW
Sequence: MIALFPNESKDPSLKIAAEICQFLISRNIEITAEDKHAKQLNVFPLSQVNVQHINFRISLGGDGTILRLIHKHPTIHAPLLGINLGSLGFLADIPLDGIFPSLEDLIKGRYRVQKRMMVEGSVLCKPSCFAVNEVVIHRAQNPCLIDLAIYVDGNYLNTFSADGMIISTPSGSTAYSLAAGGPILTPELKAFVLTPICPHTISNRPIVLMPEISIQVKYLSSYAPVEVSSDGISSFSLSTNEIFHASISSQTFDLVCLERHDYFATLREKLGWQGKLKI
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_BORBU
Sequence: MKKNLMLIFGGVSFEHEISCKSAYSIYLALLDLNKYNIYPVYIDKCTGVWYLLDSVSDPPKPINTDVLPIVSLLPGFGIFSNNKNLEIDVVFPVVHGRTGEDGAIQGVLKVMDIPCVGAGIIGSAISSNKYFCKLLLKSFDIPLVPFIGFRQHDYFLDKEEIKRNVKEVLGYPVIVKPAVLGSSIGINVAYSENQIESFIKEALKYDLTIVIEKFIEAREIECSIIGNEKMKIFSPGEVVVQDFIFYDYDAKYSVIPGNSIIFNIPAHLETNQLLSIKEYAFLTYKNLELRGMARVDFFVEKKSGTIYLNEINTIPGFTDISMFAKMCSNDGLQFKDLVDNLIDYAFQSYINRKKRIDFEN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAO1_ALIF1
Sequence: MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQNFENDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALVQFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGAGSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKDWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQEMHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVTDEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEALQQKIESYFWKPVYRRYKRTAF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: DAPB_PSEF5
Sequence: MRRIAVMGAAGRMGKTLVEAVQLRSPLSGLTAAIVRPGSSLVGADAGELASLGRLGVPMSDSLEKVVDEFDVLIDFTLPEVMLKNLAFCRKAGKAMVIGTTGLGAREKQLLAEAGKEIPIVFAANFSVGVNLSLKLLDMAARVLGDDADIEIIEAHHRHKIDAPSGTALRMGEVIASALGRDLQQVAVYGREGHTGARERETIGFATVRGGDVVGDHTVLFATEGERLEITHKASSRMTFAKGAVRAALWLDGREAGLYDMQDVLDLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_PSELT
Sequence: MAKEKFVRTKPHVNVGTIGHIDHGKTTLTAAITKYLSYKGFASFVPFEQIDKAPEEKARGITINITHVEYQSEKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVNVPAMVVFLNKVDAVDDQELVDLVEMEVRDLLTKYEFPGDEIPVIRGSALLALEANDPNDAAYKPIQELIDALDSYIPEPVREVDKPFLMAVEDVFSITGRGTVATGRIERGKIRPGDEVEIVGLSYETRKTVVTSVEMFRKELDEGLAGDNVGCLLRGIDKDEIERGQVLAAPGSITPHTTFKANVYVLKKEEGGRHTPFMKGYRPQFFIRTADVTGEITELGNNAEMVMPGDNAILTIKLIYPVAIEKGMRFAIREGGRTVGAGVVAEIVE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_CERS1
Sequence: MSYIPFPDISPELFSIELFGVTFALRWYALAYIAGLLIGWRLVLRMIRAERLWSFGPPMTEDQLERLLTWVILGVILGGRLGFVLFYQPAHYLAHPLDILKVWEGGMSFHGGFLGVMTALVAFCLKERISILPVADLLAAATPPGLFLGRIANFINAELWGRPTTLPWGVAFPGEAAQSCPGIEGICARHPSQIYEAGLEGILLFAVLSLLVWRRGWLHWPGSVSGMFLAGYGATRFLVEFVRQPDAQFVSAGNPLGLAWQISGYGLTMGQILSLPMILLGLYLILRSRRTA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PANB_CYAP4
Sequence: MVVTIPQLQQWKRSGRAIAVLTAWDWLWASLLDQAGVDLILVGDSLAMVALGHKNTLPLSLDEMLHHTRAVCRGVQRALVVCDLPFGSYQESPQQAVRSASRVLKETPAQAVKLEGGYPAMVETVTHLVRAGIPVLGHVGLTPQSVHQYGGYPQQGKSVEAAERILSEAIALEQAGAFAIILEHIPADLGLTITQKLSIPTIGIGAGPHCDGQVLVTADALGLSERQPPFAKAYANLRETILQAVQEYCNEVQTHQFPGSG
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_YERPG
Sequence: MRVLHVCSELFPLLKTGGLADVIGALPAAQLAEGADVRIILPAFPDLRRGIPETVLVREIDTFAGRVALRYGHYRGIGIYLIDAPALYDRAGSPYHDASLYAYSDNYLRFALLGWMACELACGLDGYWRPEVVHAHDWHAGLTCAYLAARGRPARSVFTVHNLAYQGLFSADHLSELHLPAEFFQIYGLEFYGQISYLKAGLFFADHVTTVSPTYAKEITQPAFGYGMEGLLQALARQGRLTGILNGVDSDIWDPQSDTLLPTRYDAENLQAKAINKTHLQTAMGLQLAENKPIFAVVSRLTVQKGLDLVLEALPELLALGGQLVVLGSGDATLQEAFLAAAAEHSGQVGVQIGYHEAFSHRIIAGSDVILVPSRFEPCGLTQLYGLKYGTLPLVRHTGGLADTVVDCALENLADGSASGFVFNECEAQALVKAIRRAFVLWSRPKHWRHVQRHAMRLDFGWQLAAVDYLSLYRRL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: FLGE_BUCAI
Sequence: MIAISGLLANNDYMEIISNNIANASTIGYKSRKPLFFDMFSHSFYSNTTNGYGVGISSIIQNFNNGMLVETGRDLDLGIIKDGFFRLVDSQGHVYYTRDGQFFLDKDQNIINIQGMYLTGLNTSCSKSDFNNRSNLEPINLKNSNILKNKPTSEIMLKAFLNRNTESKSSVDNSDNKLSKPEDYMTYISIYNKEGKKEDITVSFNKKETNKWTVNVESNDSDDKETIKNSFDLTFNDDGELTSDNVFNITSKDSKKYENITLNLTGTIEQSNSDVSWEEHSQNGYPQGNLKTFDIVTNGEIIGTYCNQKQQTIGQILLSKFINPEKLQPESGNLWSATAESGEAKTAMKAGIQESGVLSNKTLEVSNVDLNKELINMIIAQRNYQSNAQSFKTEDKIINTLINLQ
What are the official names of this protein?
Flagellar hook protein FlgE.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: TOP6B_THEON
Sequence: MAEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKVIVEDNGPGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKERHPNPKGWRGTRIELEVKNVRYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLTDDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERLMNGEVDKVLRSFKGYTKVVKQVAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRPIGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVGLAYGGEISSGFDLLRYANRVPLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEIHNEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNYFLRFIEERFAQSEVEAEEVAENA
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: IMDH2_RAT
Sequence: MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNESDELVAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHGLHSYEKRLF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion.
Protein: TBA8_CHICK
Sequence: VDQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEQSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYSPIISAEKAYHEQLSVSEITNACFEPSNQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSMDGEDEGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-8 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FFAR2_RAT
Sequence: MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE
What is the function of this protein?
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity.  In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.  SCFAs serve as a source of energy but also act as signaling molecules.  That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301).  Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation.  May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine.  May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake.  Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes.  In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines.  May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils.  In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
What are the official names of this protein?
Free fatty acid receptor 2, G-protein coupled receptor 43.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GRPE_HISS2
Sequence: MSEQEKVEQEEISAELETQNEQEKPMEETEIQDGDALENAIARVQELEEQLIQAVKKEQDILLRTRAEIDNIRRRAEQDVEKAHKFALEKFAKDLLETIDNLERALSTPANVENETIKSLVDGVELTLKGLLSTVARFGVEPVGVIGETFNPELHQAISMQPTEGFESNQITVVLQKGYLLNGRVIRPAMVMVAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_PSE14
Sequence: MTQPIVVAALYKFVTLSDYVELREPLLQAMVDNGIKGTLLIADEGINGTVSGSREGIDGLMAWLKSDPRLIDIDHKESYCDEQPFYRTKVKLKKEIVTLGVEGVDPNKSVGTYVEPKDWNALITDPEVLLIDTRNDYEVSIGTFEGAIDPKTTSFREFPEYIKAHFDPAVHKKVAMFCTGGIRCEKASSYMLGEGFEEVYHLKGGILKYLEEVPEQESQWRGECFVFDNRVTVRHDLTEGDYDQCHACRTPISAEDRASEHYSPGVSCPHCWDSLSEKTRRSAIDRQKQIELAKARNQPHPIGRNYRLPSEA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: HIS6_SALRD
Sequence: MPLAKRIIPCLDVDEGRVVKGINFVDIRDAGDPVEQARTYDAAGADELVFLDITATHEDRDIMHDVVRRTADQVFIPLTVGGGLRSVDDMRAMLQAGADKVAINSAAVKDPDLIARGADAFGDQCIVVAIDAKRRDGDGPAWEVVVHGGRKPTGRDAVEWAAEAEARGAGEILLTSMDRDGTKDGYDLALLRAVTERTQIPVIASGGAGTLEHLREGLVDGGASAVLAASIFHFREHTVEEAKDHLRDAGLPVRPALNNWTDRYAPTD
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ECOK1
Sequence: MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSESILNANAQDVADARANGLSEAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAAALAQLQAGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.