PharMolix/UniProtQA huggingface dataset:
Protein: DBP10_GIBZE
Sequence: MPRRGASPTPSEGEIDIFGSLYPGETDNANGGNGGDDFDFDGLLNNPEPGNDDTDEAFIALQQAASFRKATNLKGRTVKKGGGFQAMGLNNNLLKAITRKGFSVPTPIQRKAIPLILDRKDLVGMARTGSGKTAAFVIPMIEKLRAHSARFGTRALIMSPSRELAIQTLKVVKEFSRGTDLKCVLLVGGDSLEEQFGYMAANPDIVIATPGRFLHLKVEMSLDLSSIKYVVFDEADRLFEMGFAAQLTEILHALPPSRQSLLFSATLPASLVEFARAGLQDPSLVRLDAEQKVSPDLESAFFAVKGAEKEGSLLHILHDVIKMPVGSPEGVNNDSEKGSKKRKRGADGGSGKPTEHSTIIFTATKHHVEYLANLLIYAGFAVSYVYGSLDQTARRIQVEDFRMGKTNILVVTDVAARGIDIPVLANVINFDFPPQPKVFVHRVGRTARAGQRGWSYSLVRDTDAPYLIDLQLFLGKKLVVGQETKNPSFSEDVVVGALKRDPVEGHVEWFNKSLHESEDINALRGVAVKAEKLYLRTRNSAASQSAKRSKELVGSQGWTQLHPLFGEDVDGAEQARVDMLARISGFRPQETIFEIGGRRDKGTTEAAEVMKQLRKRITPRRQTEAKADDDFEGIGDDIPAAAEAGADSDEEEVVMDEMDVDEESDDGLEVTVTNTNSKKGRTDWRDSEVFMSYTPRTFNAAEERGYGVSSGGQDPSNFVEAARGVTMDLTNDENAKSFGEPTRSKMRWDKKSRKYVSRENDEDGSKGAKMIRGESGVKIAASFQSGRFDKWKRANRLGKLPHVGEQVRPGSASHAANLPSGVRYKHKQERAPKEADKYRDDFEVRKKRVDEAREKRVGRFRDGMGSKKELKGREDIRKARIEKEKKRLKNARPTRRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CNKR3_RAT
Sequence: MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFSYRGHTKSKQPLPGRKGSESPNSFLDQESQRRRFTITDSDQLPGYSVGTNILPIKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGHGRKGEDALCRYFSNERITPIIEESASPVYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGPKKKSASSSAKASSGEPSLLVSWLTRLKLLTH
What is the function of this protein?
Involved in transepithelial sodium transport.  Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression.  Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
What are the official names of this protein?
Connector enhancer of kinase suppressor of ras 3, Connector enhancer of KSR 3, CNK homolog protein 3, CNK3, Maguin-like protein, Parturition-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the CNKSR family.
What are the subcellular locations of this protein?
Cytoplasm. Apical cell membrane; Peripheral membrane protein.
Protein: THIG_BORA1
Sequence: MSSQDTLTIAGKSYQSRLLVGTGKYKDFAETRAALDASGAQIVTVAIRRTNLGQNPGEPNLLDYVPPSRFTMLPNTAGCYTADDAVRTLRLARELLDGHDLVKLEVLGDPTNLFPNMPETLKAAKTLVDEGFKVMVYCTDDPIQCRMLEDIGVVAIMPLASLIGSGMGILNPWNLRLILDQSKLPVIVDAGLGTPSDAAVAMEMGCAAVLMNTAISGAKDPILMASAMKKGVEAGREAFLAGRVPRKLYSGVPSSPTEGLISTAK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSM_MYCTO
Sequence: MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA
What is the function of this protein?
Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor.  May be of particular importance for cysteine biosynthesis in the persistent phase of M. tuberculosis.
What are the official names of this protein?
O-phosphoserine sulfhydrylase, OPS sulfhydrylase, CysO-thiocarboxylate-dependent cysteine synthase, Cysteine synthase B, CSase B, O-phosphoserine-specific cysteine synthase, [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: UVSE_BACAA
Sequence: MIMRFGYVSHAMALWDCSPAKTITFTSFQKLSKQEREDKLYDVTKQNLEHTIRILHYNIAHEIPLYRLSSSIVPLATHPEVEFDYIGAFTPLWRKIGALIKEHNLRISFHPNQFTLFTSDKPHITTNAITDMTYHYKVLDAIGIADSSYINIHVGGAYGNKEKAIERFHENIKKLPAHIKKQMTLENDDKTCTTAETLSICQKEKIPFVFDYHHHMANLCEEPLEELLPAIFETWSHTNIVPKVHISSPKSKKEFRAHAEYIDLEFIKPFLHVAKKINHNFDIMIESKQKDLAMLQFIQELSSIRGIKRISSSTLQW
What is the function of this protein?
Component in a DNA repair pathway.  Removal of UV LIGHT damaged nucleotides.  Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion (By similarity).
What are the official names of this protein?
UV DNA damage endonuclease, UV-endonuclease, UVED.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: MTNN_ECOUT
Sequence: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: TYSY_SHESH
Sequence: MKQYLELCNRIIDEGTWIENERTGKRCLTVINADLTYNVGNNEFPLITTRKSFWKSAIAEMLGYIRGYDNAADFRALGAKTWDANANENQVWLNNPHRKGVDDMGRVYGVQGRAWSKPDGGTVDQLKKIVDNLKAGVDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLYLNSFQRSCDVPLGLNFNQVQVYTLLALIAQITGKKPGMAYHKIVNAHIYEDQLALMRDVQLKREPFEPASLSINPDIKSLEDLETWVTMDDFEVSGYQHHEAIKYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VGF_VACCT
Sequence: MLINYLMLLFAAMIIRSFADSGNAIETTLPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIMLVLVGIIIITCCLLSVYRFTRRTKLPLQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.  This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells.  Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival.  The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo.
What are the official names of this protein?
Pro-vaccinia growth factor, Pro-VGF.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
What are the subcellular locations of this protein?
[Pro-vaccinia growth factor]: Host membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Vaccinia growth factor]: Secreted.
Protein: DGTP_YERP3
Sequence: MSGIDFKQKISFQRPFSKPSSAEDEYEITRVFESDRGRIVNSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQVGRYIAKEILNRFKQDKKITAYGLDKLLDPFESIVEMACLMHDIGNPPFGHFGESAINDWFTKRMDPNGGSGSEPQSTDQCQVEVLKLCEGETELNILRSKIRHDLSQFEGNAQAIRLVHSLLKLNLTYAQVGCILKYTKPAYWSAPIPASHNYLMKKPGFYLAEENYVKELRRELNMEEFDRFPLTYIMEAADDISYCIADLEDAVEKNIFSVEQLYDHMSQEWGAVTPGDLFDKVVGAAFRQLGREQGRRSSEDQFFMYLRVNTVGKLVPHAAQRFIENLPAVFSGSFNQALLEDSSAACKLLQIFKRVAVKHVFNHPEVEQLELQGYRVISGLLDIYSPLLAMPETAFTQLVADDRHRKYPIETRLFHKLSIKHRLAYAESAERIRNLPSEQYEIYEYYYRARLIQDYISGMTDLYAYDEYRRLMAAE
What is the function of this protein?
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 1 subfamily.
Protein: Y236_THEAC
Sequence: MHDLIMSMAEVDISLDIGTKAVRLARAAASSYLRNEKLPDPPADPIFQEKHGVFTTINTYPGNTLRGCIGFPEPYYPLGEGIIRSSIYAATEDPRFEPMKIDEISHVTFEVSILTQPVEITVNPEDRPKAVHIGRDGLIAVYNGASGLLLPQVATEYRMNPEEFLEALCEKAGLWEGCWKYKKVKISKFQATVFGEKDPEGVVEKR
What are the official names of this protein?
Protein Ta0236.
Protein: AROK_ACIBY
Sequence: MPSKAFETLPNIYLVGPMGAGKTTVGRHLAELLGREFLDSDHEIERKTGATIPWIFEKEGEVGFRTRETVVLNELTSRKALVLATGGGAITQAPNREFLKQRGIVVYLYTPVELQLQRTYRDKNRPLLQVENPEQKLRDLLKIRDPLYREVAHYTIETNQGAARDLAQKILQLILSNKLK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_STRPF
Sequence: MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATPF_RANMC
Sequence: MKKVTDSFVSLGHWPSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILSTIRNSEELRGGAIEKLEKAKARLRKVKAEADEFRTNGYSEIEREKCNLINSTYQNLERLENYKNETIQFEQQRAINQVRQRIFQQALQGALGTLNSCLNNELHLRTISANIGMFGAMKEIT
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CYCTI_TITOB
Sequence: MKFIIVLLLLTALTLTSIPVIEGILKRCKTYDDCKDVCKARKGKCEFGICKCMIKSGK
What is the function of this protein?
First cyclic scorpion trypsin inhibitor (Kd~0. 5 nM).  Does not inhibit chymotrypsin.
What are the official names of this protein?
Cyclotide trypsin inhibitor TopI1.
What are the subcellular locations of this protein?
Secreted.
Protein: MSHD_MYCVP
Sequence: MTSQDSVDWQDVLPVDERQRIRDLISDATSADGVAPVGDQVLRELGQQRTRHLVALQDGALRGYLNLAPAGDGAPPMAELVVHPDARRRGIGSAMIRTALSVGGPDTRIWAHGDLEPARATAAALGLSAVRELLQMRRSLADLPTAPPVDGVRFATYAGPQDDAEVLRVNNAAFSWHPEQGGWTEADIAERRDEQWFDPDGFFLAFDEDSGRLLGFHWTKVHSATLGEVYVVGVDTAAQGRGLGGALTLIGLHHLADRLLSSGHDADVMLYVEADNTAAVKTYRRLGFEVVNTDVAYAVEG
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: GPMA_STAA2
Sequence: MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CSN7A_MOUSE
Sequence: MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPASGTNQRQPSKKASKGKGLRGSAKIWSKSN
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, JAB1-containing signalosome subunit 7a.
What is the protein family that this protein belongs to?
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CTU2_ASPNC
Sequence: MPGKELPDRCMNCHEAEPAFLLRERHVCQECYIRFLNFKPFRRMERYRLRRNMPQTGPCKLLLPLSYGVSSTVLLHMLHRQLEALRSKKHGPAGFEILVLVVEPSTISPVPPHEEGFALAQQTFPLCSFTRLPFHSIFELDPDVHQIMSQYAGEHFTDDTSLSDEERLNRFRRSITTATSKSDVDQILLNKLVVAFAKKMECRGIVWGDSDSKLAAKTLANVAKGRGSAVTWQVCDGMSPFGLEFNFPLRDVFTAEIRTYATLFPELAGIIVHDEPPSENTLTKNLSIDELMIRYVSTQGEKYPGVMLNVTRTASKLQSSGTSIGGLQCNFCGAFMTTNENITGEQGNEQLQFCYACARSQPELSC
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_SULDN
Sequence: MKTYKIALIKGDGIGPEIIDEAVKVLDAVASCCDLEFSYEEALMGGCAYDITGDPLPQETINISLNSDAVLFGAIGGAKWDNLPREKRPESGLLRFRKELGVYANLRPANVFDELINASSLKAEVIKGVDLMVVRELIGGIYFGEPKGRDENRGWNTMVYTREEIVRIAHQAFKIAMSRSKRVCSIDKANVLDVSQLWREVVIEVAKEYPEVELTHMYVDNAAMQLIRDPRQFDVMLTGNIFGDILSDEASMLSGSIGLLPSASVGAKIGVYEPIHGSAPDIAGQGIANPIATILSASMMLRYALGEHGAADKIDAAVKRALKEGYRTKDLAQYDAKEVCSTSEMGSIIANYAAK
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGR1_MOUSE
Sequence: MVQAKSWTLKKHFEGFPTDGNFELKTTELPPLNNGEVLLEALFLSVDPYMRVAAKKLKEGDRMMGEQVARVVESKNSAFPKGTIVAALLGWTSHSISDGNGLTKLPVEWPDKLPLSLALGTVGMPGLTAYFGLLDICGVKGGETVMVSAAAGAVGSVVGQIAKLKGCKVVGTAGSDEKVAYLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNVGGEFSNAVILQMKTFGRIAICGAISQYNRTGPCPQGPAPEVVIYQQLRMEGFIVNRWQGEVRQKALTELMNWVSEGKVQCHEYVTEGFEKMPAAFMGMLKGENLGKTIVKA
What is the function of this protein?
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX).  Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity).  Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity).  Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity).  Plays a role in metabolic detoxification of alkenals and ketones.  Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity).  May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
What are the official names of this protein?
Prostaglandin reductase 1, PRG-1, 15-oxoprostaglandin 13-reductase, Dithiolethione-inducible gene 1 protein, D3T-inducible gene 1 protein, DIG-1, Leukotriene B4 12-hydroxydehydrogenase, NAD(P)H-dependent alkenal/one oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the NADP-dependent oxidoreductase L4BD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRDD_VIBCM
Sequence: MFLLWCKELIVINTNPKRSDEPVWWSLFGAGGTWFAMITPITVLVLGILAPLGVIDAEALSYERVSSFATSIIGALFIIGTLALPMWHAMHRVHHGMHDLKFHTGVAGKIACYGFATIISALAVVFIFMI
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PMTJ_ARATH
Sequence: MNPSQQHLPKLCPKRLFLFFTPFLLFSLYYILTTIKTITISSQDRHHPPQLHVPSISHYYSLPETSENRSSPPPLLLPPPPSSSSSLSSYFPLCPKNFTNYLPCHDPSTARQYSIERHYRRERHCPDIAQEKFRCLVPKPTGYKTPFPWPESRKYAWFRNVPFKRLAELKKTQNWVRLEGDRFVFPGGGTSFPGGVKDYVDVILSVLPLASGSIRTVLDIGCGVASFGAFLLNYKILTMSIAPRDIHEAQVQFALERGLPAMLGVLSTYKLPYPSRSFDMVHCSRCLVNWTSYDGLYLMEVDRVLRPEGYWVLSGPPVASRVKFKNQKRDSKELQNQMEKLNDVFRRLCWEKIAESYPVVIWRKPSNHLQCRKRLKALKFPGLCSSSDPDAAWYKEMEPCITPLPDVNDTNKTVLKNWPERLNHVPRMKTGSIQGTTIAGFKADTNLWQRRVLYYDTKFKFLSNGKYRNVIDMNAGLGGFAAALIKYPMWVMNVVPFDLKPNTLGVVYDRGLIGTYMNWCEALSTYPRTYDLIHANGVFSLYLDKCDIVDILLEMQRILRPEGAVIIRDRFDVLVKVKAITNQMRWNGTMYPEDNSVFDHGTILIVDNSIK
What are the official names of this protein?
Probable methyltransferase PMT19.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RS13_THEAC
Sequence: MAKGSANNVKVNQDAGKSQPEKKENKDFQYIVRIANKDLNGERLLPLALSDLKGIGERLGYVIAERLDLPIDKKIGELKEEQLEKLREYVEAKEYDLPEWLLNHRREPVTGKNLNLVSTDLEIQVQEDINLMKKIRSYKGIRHEKGKKVRGQRTRSNGRKGLSIGVVRKKE
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: Y594_BACP2
Sequence: MLQQLLSNAFTMVLIILVINIVYVSFSTMRLILTMKGRRYAAAFAGTIEMLIYVIGLSIVLDNLDQIQNVIAYALGYGMGIIVGMKIEEKLALGYTTVNVITKELDVDLPRQLREKGYGVTSWVAGGLEGDRTALQILTPRKYELQLYETIKTLDSKAFIISYEPKSIHGGFWVKAVKKRRIKE
What are the official names of this protein?
UPF0316 protein BPUM_0594.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YAJD_SALTY
Sequence: MAIIPKNYARLESGYREKALKLFPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEADQYGSTVIAGEDAQKDVGEATYNPFADLKAMMNKKK
What are the official names of this protein?
Putative HNH nuclease YajD.
What is the protein family that this protein belongs to?
Belongs to the HNH nuclease family.
Protein: RIR2_HHV11
Sequence: MDSAAPALSPALTALTDQSATADLAIQIPKCPDPERYFYTSQCPDINHLRSLSILNRWLETELVFVGDEEDVSKLSEGELSFYRFLFAFLSAADDLVTENLGGLSGLFEQKDILHYYVEQECIEVVHSRVYNIIQLVLFHNNDQARREYVAGTINHPAIRAKVDWLEARVRECASVPEKFILMILIEGIFFAASFAAIAYLRTNNLLRVTCQSNDLISRDEAVHTTASCYIYNNYLGGHAKPPPDRVYGLFRQAVEIEIGFIRSQAPTDSHILSPAALAAIENYVRFSADRLLGLIHMKPLFSAPPPDASFPLSLMSTDKHTNFFECRSTSYAGAVVNDL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase small subunit, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RS6_CROS5
Sequence: MSQHYEMIFILRPDLSEEQVNQAVAKYQEFLTENNATDLQTKIWGKRRLAYPIQKKVDGIYVQFNYQADGSQVAPLERMMRLGEDVMRYLTIKLDHVSSETAEEEESEPAQSEPVASEA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SCPB_BACSU
Sequence: MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIMADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVSYKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGLKTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.