PharMolix/UniProtQA huggingface dataset:
Protein: LPXK_HAEDU
Sequence: MNIWQKKSIISWLLFPFSCLFWLISQIRWYLFRKNWLKSYRSPVPVLIIGNISVGGNGKTPLVVWLVEQLQARQINVGVISRGYGGKTTQFPQLVDAQSQAEMVGDEPVLIVQRTGVPLAISPNRKQSIELLLSRFPLDLIISDDGLQHYALQRNIEWVVIDGERRFGNGFLLPAGSLRELPSRLTSVQAVICNGGTANIGEHFMKLDATFAQNLLTGEQRPLSHFTQACVAMAGIGYPPRFFNMLRRLGLQLTQTYSFADHQAFNAVQLATLASHETPLLMTEKDAVKCRHFAQANWWYVPVNATFSAESTTYLMTEILKYLGKSNE
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: PIMT_METM5
Sequence: MPLNEIIGVIGNLISKGYIQKQSVIDALMSVPRHKFIPKAMEEYAYIDSPLGIGCGQTISAIHMVGIMCEELDLDVGQNVLEVGTGSGYHAAVVSEIVGESGKVTTIERIPELFEKSKQVLSELGYENVEVVLGDGTKGYLENAPYDRIYVTASGPNVPIALFEQLNDGGIILAPVGSHFQTLMRYKKINGKIFKEKLLEVAFVPLIGENGF
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_BRUA2
Sequence: MSDKAAGETKNGNGATTEPSLNILAQYVKDLSFESPGAPLSLRPREKAPSININVNVNANPLSETDFDVVLTLEAKAVDGKDILFNTELVYGGVFRIQGIPQEHMLPLLFIECPRLLFPFARQIIADATRNGGYPPLMIDPIDFAQMFQQRMAEEQAKSAVKS
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPFN_SALNS
Sequence: MDWLAKYWWILVLVFLVGVLLNVIKDLKRIDHKKFLANKPELPPHRDFNDKWDDEDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y4LG_SINFN
Sequence: MLSPSEFTIGTLGSAAPLSLILPRTKYEATMLVGHVDKAPAAVFLSGEFAFHYFPSTDNDSWRGLIVPGVRVEVDETSVFDQGQTMAPLGAAIRIDTRLAIRAKSEHSLSGSSALTIHDKLVSAGDLRAGFTRWQIVIGEGQTKRVLWQRSDEDEAAKSSA
What are the official names of this protein?
Uncharacterized protein y4lG.
Protein: RPE1_ORYSJ
Sequence: MAAAAAAKIAPSMLSSDFANLAAEADRMVRLGADWLHMDIMDGHFVPNLTIGAPVIQSLRKHTKAYLDCHLMVTNPSDYVEPLAKAGASGFTFHIEVSRDNWQELIQSIKAKGMRPGVSLRPGTPVEEVFPLVEAENPVELVLVMTVEPGFGGQKFMPEMMEKVRALRKKYPSLDIEVDGGLGPSTIDVAASAGANCIVAGSSIFGAAEPGEVISALRKSVEGSQNKS
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase, cytoplasmic isoform, Cyt-RPEase, Pentose-5-phosphate 3-epimerase, PPE, RPEcyt, Ribulose-5-phosphate-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS29_RAT
Sequence: MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDESLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway.  The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.  The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5.  Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).  Acts also as component of the retriever complex.  The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1).  In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.  The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes.  Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 29, Vesicle protein sorting 29.
What is the protein family that this protein belongs to?
Belongs to the VPS29 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome. Late endosome.
Protein: MAL2_HUMAN
Sequence: MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP
What is the function of this protein?
Member of the machinery of polarized transport.  Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
What are the official names of this protein?
Protein MAL2.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.
Protein: TRUB_SYNWW
Sequence: MHGFLNINKPQAMTSFDVIKKLKKVLPRKYKLGHLGTLDPMAEGVLPVAVGCGTRIIPFVEDETKEYIATMTLGASSDTQDAWGVITYHTPRKIEPAQVEKVLALFRGKSRQVPPMYSAVHHEGKRLYELARQGLEVERKAREIEIFELELLNADWEQELPQLSLRVSCSRGTYIRTLCHDIGQELGCGAYLSSLRRSRSGCFKIEEAVSLDYIIEKRENLSRALLPLDYPINNLPLISLKSAELPAIINGRQISRTGKLASPRVRLYTPEGQLLAIAEANNYNEDTVLQPCRVFKINE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RPOZ_CLOBL
Sequence: MSNSMINPSIVNLLEKVDDRYSLVTITSKRSRQLIDGAKPLVDIDSTKPVTVAINEIHEGKITYKTVKEGIK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: MYRA_MICGR
Sequence: MHPDLLPHLRCPVCGQPLHQADAAPPRALRCPAGHSFDIARQGYVNLLTGRAPHVGDTAEMIAAREEFLAAGHYDPFSAALATAAARAVPRRVRPGDGVGEPVAYPDLVVDAGAGTGRHLAAVLDAVPTAVGLALDVSKPALRRAARAHPRAGAAVCDTWGRLPLADATVAVLVNVFAPRNGPEFRRVLRPDGALLVVTPTAEHLVELVDRLGLLRVDPAKDARVADSLTRHFEPAGQSTHRHRLQLTRKEVLTLVGMGPSAWHTDPARLTARVAALSEPVTVTAAVRLARYRPI
What is the function of this protein?
Confers strong resistance to mycinamicin (MM) and tylosin (TY).  May function as methyltransferase.
What are the official names of this protein?
Putative 23S rRNA (guanine-N(1)-)-methyltransferase, Mycinamicin-resistance protein MyrA.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmA family.
Protein: HRR25_YEAST
Sequence: MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQRDLLIEKGDLNANSNAASASNSTDNKSETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTILNNNAASSLPEELLNALDKGMENLRQQQPQQQVQSSQPQPQPQQLQQQPNGQRPNYYPEPLLQQQQRDSQEQQQQVPMATTRATQYPPQINSNNFNTNQASVPPQMRSNPQQPPQDKPAGQSIWL
What is the function of this protein?
Protein kinase which phosphorylates serine and threonine residues (PubMed:1495994).  Can use casein as a substrate (PubMed:1495994).  Phosphorylates elongator complex member ELP1/IKI3 on 'Ser-1198' and 'Ser-1202' which promotes the tRNA modification function of the complex (PubMed:25569479).  Associated with repair of damaged DNA and meiosis (PubMed:1887218).
What are the official names of this protein?
Casein kinase I homolog HRR25.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: AGRB_CLOBE
Sequence: MIKYLSTNISLYFQENNSCLSKKDVLKIQYTLEAILSDLSKFIIIFLVFLFIKEIPLFLFSFIILNSTRPLLGGIHCKTYYGCLTCSILYFMIILLFTRLFPELNTNFYIVFFILSLAITFIFAPCPNEKRPVKNKATLKILSLISLTFWIILFYLSPLQTRNCILISIFLQIIQVIIINTKGVIFNAKNNKTFFNRTT
What is the function of this protein?
May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor.
What are the official names of this protein?
Putative AgrB-like protein.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VOPP1_XENLA
Sequence: MKSLHCVGLYLLSLLCQLTEAKKHCWYFEGLYPTYYICRAYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPLLVDEPTFNVSYTRQPAGPPGGPQQPVMPYYSDPGGAMGNPMTPSFYVQPNSPQGNPPFPPPPSYCNTPPPPYEQVVKSYK
What is the function of this protein?
May be involved in the transcriptional activity of NFKB1.
What are the official names of this protein?
Vesicular, overexpressed in cancer, prosurvival protein 1, EGFR-coamplified and overexpressed protein homolog, ECop.
What is the protein family that this protein belongs to?
Belongs to the VOPP1/ECOP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
Protein: SSH4_NEUCR
Sequence: MITMPDYRPGMNGIIIGLLSSFGSAILIGCFFLIFYFFRCTTSGRIFLDRIGRPGEYDDEQQFLREEAEALETMDDMQRTEYLRAKAFIAANPPESLQTDISLSQYLAIQEKGVSAWEFEPELEIANCFVEARTEIEFFDSECTVMSNLPVPKQNEVYYWEAKIYDKPENTLISIGMATKPYPLFRLPGFHKYSVAYLSNGTRRYNQPFNATSYGPQVVQGDVIGVGYRPRSGTIFFTRNGKKLEDVVHGLKSQNFFPSIGANGPCIVHVNFGQAGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLEAGTKDGFTSTLGRGRGYSHPVQTYSRQGLAAVDSSHNRTRSGNFRMFPPTSPGPVRSPTDISLAHLVPTEDAGEPSSSAAALVDQDGQPITGGFLSPDQPPPEYTSPVNSRPGSRRHSSDSENTPLIQLSGRSRGASSATARPIQSGGSHNRPRAGSHRPPSPPIPSYQDAVRQGAGRDRSDSTRSARDSS
What is the function of this protein?
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport.  May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
What are the official names of this protein?
Protein ssh4.
What is the protein family that this protein belongs to?
Belongs to the SSH4 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: ROT1_YEAST
Sequence: MWSKKFTLKKLILGGYLFAQKVYCEDESNSIYGTWSSKSNQVFTGPGFYDPVDELLIEPSLPGLSYSFTEDGWYEEATYQVSGNPRNPTCPMASLIYQHGTYNISENGTLVLNPIEVDGRQLFSDPCNDDGVSTYSRYNQTETFKEYAVGIDPYHGIYTLQLYQYDGTPMQPLYLAYRPPMMLPTETLNPTSSATSTDDPSSNKKRSLRSLVRRSLENRHKTNAIKRQNTSFLTSNAIWYISAGMLGVGSLLFLAF
What is the function of this protein?
Required for normal levels of the cell wall 1,6-beta-glucan.  Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.  Controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability.
What are the official names of this protein?
Protein ROT1, Reversal of TOR2 lethality protein 1.
What is the protein family that this protein belongs to?
Belongs to the ROT1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: METK_TRIV2
Sequence: MSRRYLFTSESVTEGHPDKICDQISDTILDTLLTQDPTSRVAAEVVVNTGLVLITGEITTKANVNYANIARQKIAEIGYTNADNGFSASSTSVIVALDEQSPDIAQGVNTAQETREQDSEELFDKIGAGDQGIMFGFACNETPELMPLPICLAHRIARRLAAVRKTGELSYLRPDGKTQVTVVYEDGRPVGIDTVLISTQHTATIGDITDEAAVQAKIKQDLWTAVVEPVFGDLEIKPDQETRFLVNPTGKFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLAEKCEVQLSYAIGVARPVSIFLDTFGTGKVDDEILLGLVKDNFELRPAGIIHSFNLRNLPSERGGRFYQDVAAYGHLGRNDLDLPWERTDKADFLKQAVTHSLSAAIA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1879_CLOBA
Sequence: MNTNKILETIKMIEEEKLDIRTITMGISLLDCIDSDGEKARMKIYDKITKSAEHLVEVGRQIESEYGIPIVNKRVSVTPISIIAGATNEDSYVKFAQTLDKAADTLGIDFLGGFSALVQKGCTKGDKILISSIPEALAITQKVCASVNVGCTKSGINMNAVRDMGEIIKKTAELTKDKKGFGCAKLVVFANAVEDNPFMAGAFHGVGEAEKIINVGVSGPGVVKRALEKVRGQSFDIVAETIKKTAFKITRMGELVANEASRRLDVPFGIVDLSLAPTPAVGDSVAEILEEIGLERVGTHGTIAALAMLNDAVKKGGVMACSHVGGLSGAFIPVSEDAGMIEAVINGSLNLEKLEGMTCVCSVGLDMIAIPGDTPASTISAMIADEAAIGVINNKTTAVRIIPAPGCKVGDMVEFGGLLGTAPVMKINENSSELFAQRGGRIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein CLH_1879.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: Y1635_METJA
Sequence: MSNKTKLKDNKELLYQVVLSYKVSHNYPLKAFLIECKNKLNECIDMIWNNIKYTKKDNPKLPKSNEFKRELRNKLLENWNYASHYIDGIIKTSYSILQSWASNYKRGYRTKTKPIAKRLFVRVKTTLIKYDKEKGEIRITIKPRKDYLILNIKNEWFFDKVKNLTIGEIILKEKETFLTFKDNLNYSDKGMIVGVDSNLRSLDLFHPIEGWTRVDLTELHRIKEVYDRKIDFLKKLLKKFPLRAMRKINRLFERRRNRVKDFLHKLTIQLSRLFPDAIFVFEDLNKRRMYKSKYFNRKIDRVNWNGLIEKISYKTIVILVNPAYTSTICPICGSRMESQEGQVVYCSNCLNSFNRQLVGCYNIFKRGLGNIKEIMGGSGVTTTGVEVSFGKLMTPNPNVIYIVDYNGKYFNEIA
What are the official names of this protein?
TnpB-like protein MJ1635.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transposase 35 family.
Protein: RS21_PSEA8
Sequence: MPAVKVKENEPFDVALRRFKRSCEKAGVLAEVRSREFYEKPTAERKRKAAAAVKRHAKKVQREQRRRERLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: DXS_VIBPA
Sequence: MTLDISKYPTLALANTPEELRLLPKETLPTLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPVDKLIWDVGHQAYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAGLGLAISAQKEGKGRKVISVIGDGAITAGMAFEAMNHAGDVHPDMLVILNDNEMSISENVGALNNHLAKVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPGTLFEEFGFNYIGPIDGHDVNELVKTLKNMRELKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPSHNCLPKSSGGKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEFPDQYFDVAIAEQHAVTLATGMAIAGDHPIVAIYSTFLQRGYDQLIHDIAIMDLPVMFAIDRAGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHKHTGPSAVRYPRGSGMGTEIEKEFTALEIGKGRVVRKGEKVAILSFGTFLPNALEAAKNLNATVADMRFVKPLDEALIRQLADEHDVLVTLEENAIAGGAGAGVIEFMMKEKIIKPVLNLGLPDKFIHQGTQEELHEELGLDAKGIEKSIAEYLAK
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: TYSY_RHOBA
Sequence: MQGYLQLLDEVLHDGIDRDDRTGVGTRSLFGRQMRFDLAEGFPLLTTKKLHIRSILHELLWFLRGDTNIGYLKENKVSIWDEWADEAGDLGPVYGHQWRSWEGANGDTVDQIAWVENEIRTNPRSRRLVVSAWNVADVPKMALPPCHLLFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYAMLTSMMAHVTGLKPGEFVHTLGDVHLYSNHFDQAREQLSRTPRPLPTFHIKRDVASVTDFQFDDFELTNYDPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I67A2
Sequence: MSLLTEVETPIRSEWECRCNDSSDPLVAAASIIGILHLILWILDRLFFKCIYRRFKYGLKRGPSTEGVPESMREEYRQKQQNAVDVDDGHFVNIVLE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CPHE_PSEAG
Sequence: MIRSFIRSSALLLALLPVTGYSAGPLILVGGGLKDDNTAIYQRLIQLAGGNGQARIGVITAASIPESDDPDAGTADAANSKANGEFYAQLLETYGAADAQWIPIDLDQISNNSNPQVVAQINSMTGFFFGGGDQSRLTQTLQTATRADSPALAAIRARHNAGAVLAGTSAGTAIMVQGPMVTGGESYDGLRYGVYTTPSGDDLSYDMQGGFGFFNYGLLDTHFSERGRQGRIVRLADHTQVPFAFGVDENTALLVQNNATLGQVEMEVIGENGVFIFDLRNKERGTGSTYALYDVLGSYLTAGDRYRPVTGQFVIASGKTSLRGRERYSAAMTVTTDIFSSPNNSGANGRRKPREFVKVSADLFDSRVTSTLGRTYETNPLSRRSVQKHAVRQPWLPGHRWRQEHAVLPAFADGFPS
What is the function of this protein?
Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
What are the official names of this protein?
Cyanophycinase, Extracellular CGPase, CPHEpa, Extracellular cyanophycinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y338_CHLL3
Sequence: MVEFHEKRGNAVFGVRVQPRSSKSAVSGPYGNALKVTLKAAPVDDAANRECCRLFSKLFSIPDSRVSIVSGAASRTKSVMLEGLSAEEARSILRNSSIPGL
What are the official names of this protein?
UPF0235 protein Plut_0338.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: GRCA_SALPC
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKSGFAEDEVVAVSKLGEIEYREIPMEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: ATPD_THEMA
Sequence: MRFSAVAGRYARALLNVAIEKEKEEEYLRFLDLVCQIYESSRELFDNPILKPEKKISLIKEIMKSFGQEMDEFQERFLTLVFERKRQKLLRNIRDLFEYEKILSEQKVPANLSIAHSPEDEELSLLRKFVRKYALKDPVFDISIDESLIAGALVEFEGFRLDTTVQGRLKRIAREALKRGEMS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UPPP_LACPL
Sequence: MLDIFKAVILGIVEGITEFLPISSTGHLVLVDEFIKMQQSTQFTDMFNVVIQLGAIMAVVVLYFHKLNPLSPRKDTTEKRNTWVLWSKVLLAVIPSVIVGLPLNDWMDEHLMNWAVVSATLIIYGVLFIVIENHNKRLTPRFANLQTLPYTTALFIGCFQLLSLIPGTSRSGATILGAILIGTSRYVATEFSFFMAIPTMFGASLLKLVKFFAHGGSLAGLQGAVLAVGVIVSFVVAYLSIRFLLDYIKKNDFKAFGWYRIVLGVLVIGYFTLIH
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.