PharMolix/UniProtQA huggingface dataset:
Protein: SSH2_MOUSE
Sequence: MALVTVQRSPTPSTTSSPCASEADSGEEECRSQPRSISESFLTVKGAALFLPRGNGSSTPRVSHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARMHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELNKKEMTTSADQIAEVKTVENLAAMPTVFMEHVVPQDANQKGLHTKERVICLEFSSQEFRAGQIEDELNLNDINGCSSGCCLSESKLPLDNCHASKALLQPGQAPDIANKFPDLAVEDLETDALKADMNVHLLPMEELTSRLKDLPMSPDLESPSPQASCQAAISDFSTDRIDFFSALEKFVELSQETRSRSFSHSRIEELGGGRSEGCRLSVIEVAASEMAADDQRSSSLSNTPHASEESSVDEDQSKAITELVSPDIIMQSHSENAISVKEIVTEIESISQGVGQVQLKGDILSNPCHTPKKSTIHELPLERVPAPESKPGHWEQDESFCSVQPELARDSGKCAPEEGCLTTHSSTADLEEEEPVEGEHDWGPGMHSGAKWCPGSVRRATLEFEERLRQEQENHGTASAGPTLSNRKNSKNDSSVADLMPKWKSDETTPEHSFFLKEAEPSKGKGKCSGSEAGSLSHCERNPTMPDCELLEHHSLPAPQDCLGSDSRSKKQEGDLKKQRAVVPNQECDTQAILLPLPKKIEIIEYTPTVTSLGHTEPGGEATPSKEGEKQGLRKVKMEQSITMFCALDENLNRTLEPSQVSLHPQVLPLPHSSSECDRPADPNPMLSSPQDKGDCPSTPFKTAAPFVSCSTQGASFSLDYLLPHSVVHLEGCTEQSSATDNELSPEQASWEDSRGHFLSSGSGMAHTSSPLTNEDLSLINKLGDSVGVLQKKLDPSPEACRIPHSSSSENIRDLSHSRGVVKEHAKEIESRVIFQAGFSKTSQMKRSASLAKLGYLDLCKDYLPDRELVSSESPHLKLLQPFLRTDSGMHALMAHEPSESAGAQQNPQPTKYSVEQLKTSECIVQSKPVERPSVQYAKEFGYSQQCLLPKARPELTSSEGGLPLLQTQGLQYTGPSPGLAVAPRQQHGRTHPLRRLKRANDKKRTTNPFYNTM
What is the function of this protein?
Protein phosphatase which regulates actin filament dynamics.  Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.  Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
What are the official names of this protein?
Protein phosphatase Slingshot homolog 2, SSH-like protein 2, SSH-2L, mSSH-2L.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Also localizes to focal adhesions.
Protein: GCYDB_DROME
Sequence: MYGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEGPE
What is the function of this protein?
Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments.  Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity.  When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
What are the official names of this protein?
Soluble guanylate cyclase 89Db.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AQPZ_CHRVO
Sequence: MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCHLNPAVSIGLWAGGRFPAGQLAPYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYAEHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFAPLAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSAA2_STAAR
Sequence: MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWKGNWHPSQLNQDNGYYSYYYYNGYNNYSYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYNTNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNNNGSVRVSEMNYGYGPGVVTSRTISASQAAGYNFIH
What is the function of this protein?
Not known; immunogenic protein.
What are the official names of this protein?
Staphylococcal secretory antigen ssaA2.
What are the subcellular locations of this protein?
Secreted.
Protein: STX1B_SHEEP
Sequence: MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTTDIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL
What is the function of this protein?
Potentially involved in docking of synaptic vesicles at presynaptic active zones.  May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).
What are the official names of this protein?
Syntaxin-1B, Syntaxin-1B2.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: LUXS_STRGC
Sequence: MSKEVIVESFELDHTIVKAPYVRLIGEESGPKGDVISNFDIRLVQPNEDSIPTAGLHTIEHLLAMLIRKRIDGMIDCSPFGCRTGFHMIMWGRHTPSEIAQVIKSCLEEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILKQGISDNAFERHVI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: ZAPA_YERPN
Sequence: MSAQPVDIQVFGRSLRVNCPPEQQDALNMAAEDLSQRLQDLKVRTRVNNTEQLVFIAALNVCHELAQERLKTRDYASNMEQRIRMLQQTIEQALLEQGRISDRQDTQFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: CWP03_ARATH
Sequence: KGVNDGT
What are the official names of this protein?
60 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RS8_SHESA
Sequence: MSMQDPIADMLTRIRNGQAANKVSVKMPSAKLKVAIAKLLKEEGYIADYAVADEAKPELEITLKYFQGQPVVETIQRVSRPGLRIYKGKNELPKVMGGLGVAIVSTSKGLMTDRAARLAGMGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ASTE_PSET1
Sequence: MSATTPDYIEELKQTGDFLTLSRNNEWHLAAGEFTLNNGTVVTIHDTGVIEFQPATVSSKDVVYSSAVHGNETAPIEICDELIKQIIAGELLLKQRALFIFGNPQSINIGLRFVEENLNRLFNGHHSVDGVPMNNERTRAAKLEQYVSDFFSRGEQGSSRCHYDLHTAIRGSKNEKFAVYPYLHGKPWKKSQLQFLLSCGVNTVLMMKSPATTFSYYSSFVHGADSFTVELGQVKPFGENDMSRFAKTKQTLTALISQDKVEYPEFNADEFELFTVHRTINRTQNEFSFPFSDQAENFTGFAKGELLATDGDTPYYADVQGEAIIFPNANVAIGQRALLTVVPMAIDSNFI
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: FLNB_TERSD
Sequence: MSESGGGTVATARQRQLVERALGEWQGEVAGRVIVVTGGARGIGRSLCEGLLRAGAKVVAADLTWDDADDFRKQLESDGSGMAVDMDITDDDALDAARDAVIDRFGTVDVLVNNASLVSETLFPPTGHRNTLDTTDRDWEVMFGVNVFGTLKAIRRFIEPMRAQQRGSIVNVVSSGVLAVAAGGGYHGLRPWTVEMPYQATKAAVMALTFYLAEEVRGDGVAVNAIMPGHTRASWFDATARAFNEQGIAYFMRPAIPEHLLPISLFLAAQDSAGASGRLYYVPEWNYDHGYGDYAAWQDHELPPDMEEIYSRLEAATPSYERAGVAHLPFDAQGALYAAGMANLGAQNSWTSNDSAQ
What is the function of this protein?
Catalyzes the dehydrogenation of both 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone to produce 9-fluorenone and 2'-carboxy-2,3- dihydroxybiphenyl, respectively.
What are the official names of this protein?
Fluoren-9-ol dehydrogenase, 1,1a-dihydroxy-1-hydro-9-fluorenone dehydrogenase, DHF dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PAFA_BIFLD
Sequence: MPQLRDSGTRSLHATEPVPSAEMDGFCRIFGVETEYGVAVTGAERPVDAGQVAMTMFQPIVSRSRSTNTYLTNGSRLYLDVGSHPEYATAEARDPREALAQDLAGEHVMRNLALKAQRKLRESYGAHATIHVFKNNVDSAGHAFGCHENYLVRRFVPLETIEHQLLPFLITRQLYTGAGRMTPDGFQITQRADFLDEAVSSATTRSRPMVNTRDEPHADPDSFRRLHVIIGDSNRSQWSTWMKLAVTHLVLCAIEDAFRHGTPSGFEHCAFADPAAANRTVSRFLDDPHAELTLESGESVSALGLQRRYYAAVKAFIETHVDALASSLPATTIDTIMGEWSRVLDALERGAYDALADRVDWAAKKRLFDALKRRRPDVTFAQMEQLELDYHDIANGRLYGSLVARNQMRELLTGDNVEYAVHNPPTDTRAALRGRFVDAALNVGAQFSADWTHLTLTAPERREAILLDPFEAEPTLGFEQLMEALN
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: Y4297_PSEPG
Sequence: MSVSVCPCGSGNLLDACCGHYHAGTPAPDAQALMRSRYSAYVLGLVDYLVATTLPAQQADLDRAAMAAWSAQSTWLGLEVESAEVLGGQPEHGFVTFTARWHDQDGDHQHRERSAFVQHAGRWYFIDPTVGLKAGRNDPCPCASGQKFKKCCASYVGS
What are the official names of this protein?
UPF0225 protein PputGB1_4297.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: AOXA_HUMAN
Sequence: MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHAYNGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNVPI
What is the function of this protein?
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin.  Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents.  Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent.  Is probably involved in the regulation of reactive oxygen species homeostasis.  May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen.  May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.  May play a role in adipogenesis.
What are the official names of this protein?
Aldehyde oxidase, Aldehyde oxidase 1, Azaheterocycle hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I51A0
Sequence: MDPNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YOR50_YEAST
Sequence: MASVKQTNKTLREGNPEHSTIFYIRGSILAPSYFLPDFARTLFPRKDMVSVGPLFPIIFAHSDSAAIDMSGTTGKRRCLVVVAAPIVDILISNRTSCTKSCASAARPCLEGSVAP
What are the official names of this protein?
Putative uncharacterized protein YOR050C.
Protein: SYP_CHLMU
Sequence: MKTSLLFYRTSKNANKEASVLSYELLEKAGYLFKTSKGIYSYTPLFQRVILKMTEIIREELNAIGGQEVCLPLLQSAELWQKTGRWEAFLSEKLLYVLKDRENKEMCLAPTHEEVVSEFVSQWLTGRKQLPVHLYQIGTKFRDEIRPRFGLMRAKEFLMEDSYTFSDSPEQMEEQYAKLRLAYQRIFDRLNLKYVIVTADGGKIGKGKSEEFHVLCSLGEDTICVSGSYGANIEAAQAIPPSYTYSSELLPMKEVATPNVRTIEDLETFFNTPRQQIIKTLVVKVHKKGSEQFFAICIRGDRQVNLTKVSSFLQADDCELASDEEIIKHLHVEKGFIGPLHCPVPCYADETTRPMTNFICANNQKDIHCRYVNWERDIPLPIFGDFLLAESGDLCPQNNEAPYEIFQGVEVAHIFNLGTRYTECFSVGFQDENGEKQLCWMGTYGIGVGRTLAACIEQLADSKGIVWPLAVAPFSITILYNGGDTEGEAVASQFYQSLNTAGFEPLLDDRNERLGFKLKDSDLLGIPYKLIIGKSFQKTGMLEIESRSGEKYNISPENLLDWCSKNLPCHTRKIPPIRE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA43_XENLA
Sequence: MENSGCALEVRWVQGINKKKVTFINDHTVCYPCGNFIVFHDTNTGKWSFLQCTTGSTGAFAVNTYSEVVAFSDQKLHPTIYVYTFPGFVKRAELKDGAQLDYSLIAFSHAAPYLASYSSIPDHVLTIWNWQESIPLCSKSDSQTTYTTLTFNPMNWHQLCLSSERSLTVWNIEICDNQYQLKAMPVKLPSEDGTTDIEEENLNSHTSNSVSYYGPLMPTSAVAGLVGDEAEIFIPKEQRKHSVQPSFHCWNATSDLYVGCAGGQILSISAETQKVTILAQKDQSADHLSRTTLLEGNIKTMAFHKEGLYVAGNDGVLHLFTIKGSEVKLEDSWNAQEPIDSISFSPSYKTLSITTSKGSLYLYNQRNPEETYKLLNVYSRDLLAADFLTFGNKYCLGTDISGHVQLWSVEDGKSVSSLNLNIQATAMACCPSSNYAAVGSSTGHIYFIDAVKTEAPRIVQRTRLYCVPVQHMHFDPRGNFLLTGAADRHIFILDARPSYSFQVLGYIVVCGEILTLSSLSSADTQQTKVMALVCPVDERKEEKGGTQLEMFSLPLQMLSSPSEYIDERGMFKDTMIQKISYDVDQPLFSAVMGYNSSSVFGYSSNETILLKYVIHKDISGSPVTALVAEKVVRGSQLGPGVLCLSPHLKWMAVSGRDGIVYVKDLLNMETMAQLQCHSYHNGGINSLAFSLDGQSIVTTGTCDGALVCLQWKSSGRSSSRLGLAGEYGKDLALSLQAAMKEEDQALSRMPVWTADADSLGVERKGKEYSQLSVDVTEQDSFPNTSANDVTWIKRKLEEAEKKETEKYAAEKEVIKTGIKKLRKTIQAMMRENESLPDIEKLDQQEFNLDTEEQERLYLDSEKEVARVRQEIELENLSKQYLREVIKQECWDSMAVKGRSVTAFHTGYEVMNYPMKERTPKELEKFARVLNLMKIEAVDLKVRKEIVETQPKIGPDDEEEVEEELMKCQDSSSLVGSLSDHYGGDTSCLYSQLILHSREEKINQIILLQDIIQNIKNAFNKDFDTVCRQKEQEITRVMERNNRIQEIMVELNLQEKLLEPTFTDNEKPERALTVDDSEVKVERYLTPEQKAKAEHLAKVEEAKRLAAQEDNAKQRALDDMMGGVLEVKKEDILRMEVPQPVFLARTEAEWTEEEKKQFKEYEKKCKDLSEEKEKYSKEELKINNLLFSLLIEEEINTRVAHLAYILDKKRKQKNQTAEIVKSFKSQVMAFRESYDNLVAEDKLLDRGFKKEFSDITSYQVDQLYKLYKRRPRVQRLRTQADSTAPFGERPGSAKAYKDSIALLMHAMDELDTPENVPEGVELPVWQRFCLARRSKIEYEQQVKIKALVLAEMQAFLDKRIEEDEKMRQDIENFMQELNVLRNEKMKFQLDLTVQFLLKQGQVELENTDLIPSFEDAILLHRSVIEDLNSTIKGLGEQKIASMVESKDFRKGIFQLEWEHRKIRMEMEDLEKKSRDISLLHVSKEFQVFLNEQNYDKRMSDQIQVLEETINAQEKQHGKNVKTYKKILKDLETHINKKIIANLELDKDLQELLVSFSERKHIYDVVGVEQSTEKAAKERYMEIIQRRKLVDLAKIQAQEIHELRSEVDRLRMKTFPALVQMEY
What is the function of this protein?
Involved in the regulation of the beating frequency of motile cilia in multiciliated cells of the larval epidermis.
What are the official names of this protein?
Cilia- and flagella-associated protein 43.
What is the protein family that this protein belongs to?
Belongs to the CFAP43 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: YQGF_MYCPA
Sequence: MVLTQHRVPDRPGDPDQDPGRGRRLGIDVGSVRIGVACSDPDAVLATPVETVRRDRSGKHLRRLAALVTELGAVEVVVGLPRTLADRTGTSALDAIDLADQLARRIAPTPVRLADERLTTVAAQRSLRAAGVRAKEQRAVIDQAAAVAILQSWLDQRRAATREAGDG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP11A_SHEEP
Sequence: MLARGLPFRSALVKACPPLLNTGREGWGHHRVGTGEGAGISTRTPRPYSEIPSPGDNGWINLYHFWRKKGSQRIHFHHIENFQKYGPIYREKLGNLESVYIIHPEGVAHLFKFEGSYPQRYDIPPWLAYHRYYQKPIGVLFKKSGAWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFRFAFESITNVMFGERLGMLEDTVDTEAQKFIDAVYKMFHTSVPLLNLPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRQKTEFRNYPGILYHLLKSEKMLLEDVKANITEMLAGGVDTTSMTLQWHLYEMARSLNVQEMLRKEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSNPDKFDPTRWLGKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFRVEMQQIGDVNTIFNLILTPDKPIFLVFRPFNQGPPQA
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (By similarity).  Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (By similarity).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (By similarity).
What are the official names of this protein?
Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc).
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: A1CF_MOUSE
Sequence: MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDSTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRLMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRTGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQGEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYHVKGDKREDKLYDLLPGMELTPMNTVSLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFIPPKLSAYVDEAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFALTTRGDAYGTF
What is the function of this protein?
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA.  Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine.  The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity).
What are the official names of this protein?
APOBEC1 complementation factor, APOBEC1-stimulating protein.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1 (By similarity).
Protein: D19L2_HUMAN
Sequence: MRKQGVSSKRLQSSGRSQSKGRRGASLAREPEVEEEMEKSALGGGKLPRGSWRSSPGRIQSLKERKGLELEVVAKTFLLGPFQFVRNSLAQLREKVQELQARRFSSRTTLGIAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFHLYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQNSVYRVLKVN
What is the function of this protein?
Required during spermatogenesis for sperm head elongation and acrosome formation (PubMed:21397063, PubMed:21397064).  Also plays a role in acrosome attachment to the nuclear envelope (By similarity).
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L2, Dpy-19-like protein 2, Protein dpy-19 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein. Note=Colocalizes with DPY19L2 at the inner nuclear membrane.