PharMolix/UniProtQA huggingface dataset:
Protein: PHOL_MYCBO
Sequence: MTSRETRAADAAGARQADAQVRSSIDVPPDLVVGLLGSADENLRALERTLSADLHVRGNAVTLCGEPADVALAERVISELIAIVASGQSLTPEVVRHSVAMLVGTGNESPAEVLTLDILSRRGKTIRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLAMAKAVHALQTKQVTRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPELIPKLMSAGVIEVAPLAYMRGRTLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQIDLPGGARSGLRAAVDILEDIDDIHIAELTSVDVVRHRLVSEIVDAYARYEEPGSGLNRAARRASGARGRR
What are the official names of this protein?
PhoH-like protein.
What is the protein family that this protein belongs to?
Belongs to the PhoH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MET_COLGU
Sequence: MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSGNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPHHPLHSISVRRLKETKDGFVFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLSVQRETLNAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRAEFTTALQRVDLFMGQFSEVLLTSISTFVKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCQDKCVRSEDCPSGTWTQQICLPAIYKVFPTSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPIITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLHSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISIALLLLLGLFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RPOB_LEPIC
Sequence: MYGQVERKRVNFGKITNLDYLPNLIQIQKRSFDWFLQADVKDETKRRHQGLEAVFRETFPIESPNNDMIMEYSHYILGEPKRSPQECKDTDATFAMPLKAVIRLIIKETGEIREQTVYMGDLPVMTEQGTFIINGAERVVVSQLHRSPGIFFSYDMERDVFSARVIPYRGSWLEFEMDNKGILIAKIDRKKKFPATLLVKSLGHGTNEEVLRLFYSSKKEKIAGATSKDLKKILGRRTINDIINMETGEVMLEAGSKINEDNISILKEMKVKEVELIEFPKGKDNPILINALEKDGVNDYEDAILKFHSLMRQGEPSTIENATTELTRLFFSPKTFDLGEVGRYKINSKFEFNNPKEFSGEKSRVLRPADIIETVRYILNLFSETENYYPDDIDHLGNRRIRSVGELISNQLKTGFSRVERVIKERMTVQEIETQTPQLLISIKPITAVINEFFGSSQLSQFMDQTNPLAELTHKRRLNALGPGGLSRDRAGMEVRDVHYSHYGRMCPIETPEGPNIGLILSMSSYARVNDYGFLETPYRTVKNGKVTGQIEHLTADKEEYHYIAQASGVIDEKGELKNKLISTRHRGDFPFRNPSEIQYMDLAPLQVVSVSTALIPFLEHDDANRALMGSNMQRQAVPLLREEAPFVGTGMETRAAYDSRICIVNKHDGVVTSVDAENIVVERKGGKESDTYQLTKFKKTNQGTCFNQKPIVGVVHSEINGKVSKVSKEKIEVTGENGELKEYVLQIGSKQYSPIVSAGEEVKRGSTLAGQVVVGEKLDEMGNILVKGTVLADGPAVDNGVLALGRNVLAAFMPWEGYNFEDAILISERIVRDDVFSSIHIEEFEIQARETKLGPEQITRDIPNLSDKAFRDLDETGVIRIGAEVKPGDILVGMVTPKGETDLTPEYKLLHSIFGEKAKDVRDSSLRMPNGFEGTVIDIKRFSRENQDELPAGVEEMVKVFVARKRKLLVGDKMAGRHGNKGVVARVMAEEDMPYMEDGTPLDIVLNPLGVPSRMNLGQIFETQLGFAASKLGISFETPVFDGAEESDVDNFCKEANLPLNSKFKLYDGRTGLPFMNEVFCGYIYILKLAHLVEDKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGASHTLQELLTIKSDDMLGRARIYEAIVKGIHSIKPGIPESFNVLVQELRGLALDIIITDSEGNTVDISDYEDEYSKSKKKIKFETIENA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: DFB29_MOUSE
Sequence: MPVTKSYFMTVVVVLILVDETTGGLFGFRSSKRQEPWIACELYQGLCRNACQKYEIQYLSCPKTRKCCLKYPRKITSF
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 29, BD-29, mBD-29, Defensin, beta 29.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GON2_CLUPA
Sequence: QHWSHGWYPG
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Gonadoliberin-2, Gonadoliberin II, Gonadotropin-releasing hormone II, GnRH-II, Luliberin II, Luteinizing hormone-releasing hormone II, LH-RH II.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: FMO1_MOUSE
Sequence: MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFVPNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFPGILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQVLKGATTLPPPSVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVKVTKTRTIQESPSSFETLLKLFSFLALLIAVFLIFL
What is the function of this protein?
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:9580872, PubMed:32156684).  Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (PubMed:32156684).  In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
What are the official names of this protein?
Flavin-containing monooxygenase 1, Dimethylaniline monooxygenase [N-oxide-forming] 1, Dimethylaniline oxidase 1, Hepatic flavin-containing monooxygenase 1, FMO 1, Trimethylamine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NUSB_PROA2
Sequence: MKAHRRHIREKIVQALYTLDVRDTDTATAGDWLITPEISKDPKAIRFFKQLLGAIVDNREEIDQYISKHTFNWDMSRIAIIDKNILRMAMAEILYFEDIPPKVSINEAIEIAKKFNSTDKSSKFVNGILDAVYNDLNKSGKINKCGRGLIDQSSNLKKNKEKSPSDDQ
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: Y840_BRUA4
Sequence: MSSLAQASKPSAQRWGLGALIVLAILAVQASWLYFDGRIAMCECGTIKLWSGSLMTENSQHISDWYTLSHIIHGFLFYWLFTVIAPKAPLGLRLAAAVGIEAVWELVENSNFIIERYRANTSSVDYFGDSIVNSVADTVAALIGFLIAAKLPTKITVAIALFFEVLALIVIRDNLTLNVIMLLHPFEFIKQWQSGL
What are the official names of this protein?
UPF0314 protein Oant_0840.
What is the protein family that this protein belongs to?
Belongs to the UPF0314 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YBEY_NITWN
Sequence: MPNITCREQPARARRGGEKHIMIRSATPVTEILVVADCWRAEAGAEAVIHRAIATAAGMVDKDTGDAELAIMLTDDAGIRTLNANWRGLDKPTNVLSFPALQPTGPCLPDDPPRMLGDIAIAYETLRREAGDERKTFDHHLSHLAVHGFLHLIGYDHETDGEAEEMESLERQILAQLGIPDPYAPPERMT
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATL79_ARATH
Sequence: MRLLVAEAASPLSSAATPTCNSHTCRWKPYSNSTDFTANASVLLILVISALICALSLYAAIRCFLRPTLETEDDHKPDPEAAASSTPTTPTLVYSSDLELAGAEAECAICLSEFEQGESIQVLEKCQHGFHVKCIHKWLSTRSSCPTCRTSIFSQHSETPSSHINA
What are the official names of this protein?
RING-H2 finger protein ATL79, RING-type E3 ubiquitin transferase ATL79.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IF3_AZOPC
Sequence: MRKDKLKDQYRINEEIRSEEVRVVGNNVEQRIYPISEALRMAGELELDLIEISPTAVPPVCKIFDYQKFIFQQKKHQKEQKVKLSKIVVKEIRFGPQTDEHDYSFKLKHAKSFLEEGNKVKAYVFFRGRSILFKEQGEILLLRFANDLEDYGKVEQLPILEGKKMIITLAPKKVEIISRRLKR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SALHS
Sequence: MAKRDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDAQKRAAYDQYGHAAFEQGGMGGGFGGGFNGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMDLTLEEAVRGVTKEIRIPTLEECDVCHGSGAKAGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCHKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVMLKVPSETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLSEKQKQLLKDLQESFGGPTGEKNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UB2D3_HUMAN
Sequence: MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination.  Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation.  Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin.  Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin.  Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA.  Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase.  Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair.  Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus.  In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53.  Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis.  In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes.  In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.  Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 D3, (E3-independent) E2 ubiquitin-conjugating enzyme D3, E2 ubiquitin-conjugating enzyme D3, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: RL29_CAMJ8
Sequence: MKYTEIKDKTAAELATMLKEKKVLLFTLKQKLKTMQLTNPKEISQVKKDIARINTAINALR
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RR19_MANES
Sequence: MTRSLKKNPFVANHLLKKINKLNNKAEKEIIVTWSRASTIIPTMIGHTIAIHNGKEHLPIYITDRMVGHKLGEFAPTLNFRGHAKNDNKSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUTB_YERE8
Sequence: MILNARPEPIAFPTSASALIVVDMQNAYASEGGYLDLAGFDVSATAPIITNIKRAITAARAAGIQVIFFQNGWDPQYVEAGGEGSPNWHKSNALKTMRKQPELMGKLLAKGDWDYALVDELQPQAGDIVIAKPRYSGFFNTQLDSILRAKGIHHLIFTGIATNVCVESTLRDGFFFEYFGVVLEDATHQAGPDFAQKAALYNIETFFGWVSDVETFCNCIAPSAQLSQSA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: RS2_LACP7
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAEYIYTERNGIYIIDLQKSVGKVDEAYYAIKDVVANGGKVLFVGTKKQAQDSVKSEAERCGMYYVNERWLGGMLTNFKTIQSRIKRLKEIETMANDGTFEVLPKKEVIELKKEWEKLEKNLGGIKDMKEVPEAIFVVDPKKERICIQEAHNLGVKLIGIADTNCDPEELDHVIPGNDDAIRAVKLIVAKMADAVIEANQGVQLTDSTDVAEEATETVEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: EAMB_ECOK1
Sequence: MTPTLLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIVWLAWKIATSPTKEDGLQTKPISFWASFALQFVNVKIILYGVTALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQYGRQLNIVLALLLVYCAVRIFY
What is the function of this protein?
Exporter of O-acetylserine (OAS) and cysteine.
What are the official names of this protein?
Cysteine/O-acetylserine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FBX33_MOUSE
Sequence: MLLFLSVPQPRPPGARTRAGAARLVRWRRRQRLRLLQLRRLRGLLRGLRRRPGTGGRRPSRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGPGDGGSGGGTDTGTGGEDGEALQLSSRWLEVLRIYLELVLCVLLSIRNNRNLQKFSLFGDISVVHQQGSLSSTYLSRVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNPIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNASVMLKSLDNMPNDEHWKALSRKSSSLRVYLMVFDIKSEDMLKILKPSIPLERVHFDSYVTCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLQVTEESIDFDQGELADQDVDPVQNLIEQVSLGLGQSWHAVLDIESLSVFTEPNRHFYREMQSFSEDI
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Probably recognizes and binds to phosphorylated target proteins.  Recognizes YBX1.
What are the official names of this protein?
F-box only protein 33, AIG30-12-1.
Protein: ADH7_HUMAN
Sequence: MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267).  Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267).  In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267).  Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387).  Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820).  Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387).
What are the official names of this protein?
All-trans-retinol dehydrogenase [NAD(+)] ADH7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Omega-hydroxydecanoate dehydrogenase ADH7, Retinol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_ANASK
Sequence: MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQAEANANIRQLARTDKDAVEGARASLRALGDEVKKTEAALGDVEAELTRLLMVVPNPPSDSVPDGKDEHDNVVVRTWGEQKAYGFTPKPHWELGEALGVLEWQQAAKLSGSRFTILKGAAARLERAIVSFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTNMHRDEIFEASAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESEAEHEKMLDDACEVLRRLGLHFRVVLLCAGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCEDFQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQCQEADGTVVIPEPLRPYMGGLERIAAETFPRGVER
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_BURVG
Sequence: MTSPEAADTPFEPKKILAQLPHMPGVYRYYDATGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAITEDDYAIDVSNAARFLLGRQSEVMNELEQKMHAFAAELKFEQAAAVRNQMSSLATVLHQQAIEVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGDEADGVDDAAAAMPDQPVEGEGDGDGGAAARVAGAGAGASVEAEVLDAFISQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLTMAEQNARIALARLLSEQGSQQARTRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNIAGITPGDDYAAMRQVLTRRYEKMVELAAQAAAADAATGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELDGVGAKRRQRLLARFGGLRGVVAASVEELASVDGISHALAEQIYKQLH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_XANOR
Sequence: MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKGFILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYEQRGKLTRVDGVGSLDEVLERIRKALGR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y921_RICBR
Sequence: MHKDTKLLDEIKNIKSKLKSGKPAVAPKPTPKQIKAWEETHKSHLNLDTKNSSISVPPPMPDHVLLQTSKTLSVSTLPNIKFNTINQAKFLKAIEDYDLDKIKELISSNTIKIDSFGKRGKLGKTPLQYAIINDKPELAKLLIDAGANINVKTQNGRNLFELAMYNSASDQTFELLLKTNININSMDLRALSRLHNKLFSILLKPANDINTTIGKFNRTLLHQAAERNNIKKAQISINHNINVEAQDITGETALHMLKTSKMAKILLKAGSNTEAQNKLGRTPLHNAILQANKRQVNIKNIHNIVLKLIKSGANPNAVDYYGFTPLEYAIRINDSKIFKLLIKNNAKFKKNRYELFCQALESGNLTATKYLFKKEFLNNINDKNGQNYLYYIATGGNKEVLEYLVKKNHDNGKKILTQFVDKQRNTPIHIAAQNGQFEIIKNFQKLGFDINARNADGETVLHILARAQNGEMIKELIKLGADINIKNKIGKTALDKVEEDFKGISKKISNKQLQELFEESNIIARTGRIEDETKYLYQYRQDGYYKNIEREGNRGRSATLLVPEVNISLFFTGIGLLYNANDSTIRHFMPHDFWTDNARRTEDFFNMRLDNKKFVQTHSKEKFLKTYKNFLKDNPQKDYNEIIANLYPKGLIGIALQNDDLEHKLYALEAKYYVSEKYNMDLPMTIVKNKKLIP
What are the official names of this protein?
Putative ankyrin repeat protein RBE_0921.