PharMolix/UniProtQA huggingface dataset:
Protein: RS19_MYCGI
Sequence: MPRSLKKGPFVDDHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTEAMVGHKLGEFAPTRTFKGHIKDDRKAKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: NUOB2_CHLAA
Sequence: MGIEEKAGNLGIVTTTLETVVNWGRTNAMWPLLFGLACCAIEMMGAQASNYDLSRFGMELNRASPRQADLMIVAGRVSRKMAPVVRRLYDQMPEPKWVIAMGDCAACGGIFNNYAIVQGVDEVVPVDVYVAGCPPRPEALIDGIMMLHQKVMREKISGKKESPIRIDQPLVQVK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAAF4_PANTR
Sequence: MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCMENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKELEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVIQGTELKS
What is the function of this protein?
Involved in neuronal migration during development of the cerebral neocortex.  May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.  Axonemal dynein assembly factor required for ciliary motility (By similarity).
What are the official names of this protein?
Dynein axonemal assembly factor 4, Dyslexia susceptibility 1 candidate gene 1 protein homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, neuron projection. Dynein axonemal particle.
Protein: ZAPA_ECO81
Sequence: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELAQEKAKTRDYAASMEQRIRMLQQTIEQALLEQGRITEKTNQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: RS4_SHIF8
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PDXH_VIBCM
Sequence: MDLSDIRREYIHGGLRRKDLQANPIDQFNLWLQQAIDANLSDPTAMTVATVDEHGQPFQRIVLLKNVDDAGFVFYTNLGSRKAQHIAHNNKISLHFPWHPLERQVHITGVAEKLTAMENMKYFMSRPKESQIAAIASHQSSRISARGVLEGKYLELKQKFANGEIPVPSFWGGYRIRPESLEFWQGGEHRLHDRFLYSRQDDNWTVDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: UNG_LACPL
Sequence: MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVVILGQDPYHGPGQAHGLSFSVLPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVLLLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVVFILWGKAARSKIKLIDTQTNVVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMG13_ARATH
Sequence: MSTVSSDPAHAKKSRNSRKALKQKNEIVESSPVSDKGKETKSFEKDLMEMQAMLEKMKIEKEKTEDLLKEKDEILRKKEVEQEKLKTELKKLQKMKEFKPNMTFAFSQSLAQTEEEKKGKKKKKDCAETKRPSTPYILWCKDNWNEVKKQNPEADFKETSNILGAKWKGISAEEKKPYEEKYQADKEAYLQVITKEKREREAMKLLDDEQKQKTAMELLDQYLHFVQEAEHDNKKKAKKIKDPLKPKQPISAYLIYANERRAALKGENKSVIEVAKMAGEEWKNLSEEKKAPYDQMAKKNKEIYLQEMEGYKRTKEEEAMSQKKEEEEFMKLHKQEALQLLKKKEKTDNIIKKTKETAKNKKKNENVDPNKPKKPTSSYFLFCKDARKSVLEEHPGINNSTVTAHISLKWMELGEEEKQVYNSKAAELMEAYKKEVEEYNKTKTSS
What are the official names of this protein?
High mobility group B protein 13, Nucleosome/chromatin assembly factor group D 13.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SSRP_XANOR
Sequence: MSKKPTKDKANGAKATKTIALNKRARHEYHLEERYEAGLALQGWEIKAIRAGRANIVDGYAYVRSGEIYLIGAQITPLIQASTHTVPVERRDRKLLLHRAEIDKVLTRVEREGYTLVPTALYWSSNKVKLEIALAKGKQNHDKRDAAKERDWQRDKQRVMRRHNRDA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PHS_BURCM
Sequence: MIHKLTSEERKTRLEGLPHWTAVPGRDAIQRSLRFADFNEAFGFMTRIAIKAQEMNHHPEWFNVYNRVDITLSTHDAHGLTERDILLAQFIDHVCAHTQPAA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ACPS_STRS2
Sequence: MIVGHGIDLQEMEAIESARIKHQGFPKKILTEKEFERYQSLSGRRQLEYLAGRWSAKEALTKALGTGIGKIGFHDIEILNTSKGVPYVTKSPFDGNIWLSISHSGNFVQASVILEEKDD
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO5_SULIL
Sequence: MRGSSNRKIDPRIHYLVPKHEVLSIDEAYKILKELGIRPEQLPWIRASDPVARSINAKPGDIIRIIRKSQLYGEVVSYRYVISG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC1_RAT
Sequence: MGSVLGLCSVASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFATAVAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIILFFVYYTHPASCSENKAFISVNMLLCIGASVMSILPKIQESQPRSGLLQSSVITIYTMYLTWSAMTNEPETNCNPSLLSIIGFNTTRPVPKDGQSVQWWHPQGIIGLVLFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGNGRSDGSLDDGEGVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
What is the function of this protein?
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
What are the official names of this protein?
Serine incorporator 1, Tumor differentially expressed protein 1-like, Tumor differentially expressed protein 2.
What is the protein family that this protein belongs to?
Belongs to the TDE1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CCSA_AETGR
Sequence: MIFSILEHILTHISFSVVSIVMTIYFLTLLVNLDESIGFYYSSDKGIIITFFSITGFLFTRWIFSGHFPLSNLYESLIFLSWAFSIIHMISFFNKKRKKNLNAITAPSAIFIQGFATSGLLNKMPQSAILVPALQSQWLMMHVSMMVLGYGALLCGSLLSIALLVITFRKVGPFFYKKNINRKKFLTEFFSFDVLYYINERNSILLKQNINLSFSRNYYRYQLIEQLDYWSYRIISLGFLFLTIGILSGAVWANETWGSYWNWDPKETWAFITWTIFAIYLHIKTKQNGRGINSAIVASIGFLVIWICYFGVNLLGIGLHSYGSFTSN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NSCC_TRIT1
Sequence: MGKQQETILIIGAGISGLATSRLLTNNGIPNIVFEASTPDRSQGFAISLQEFGYSTLLAALGDLPLSSLIRAVAPDRQIGGTGWIDQALRDNRTGELLVAPDLTTTKQTIVRANRNALRHWIADCGEDELDVRYGHKLQSIKGKLGDVTAIFENGAKYKGSLIIAADGVNSTSRSQILPDVVPETIPLIHYHGEFQLSHSAFDELIRPHSGHSNILVGVGDSFNTPLSICNITKTRVHLDWSYSRTVKGENDILYRPNVQSEEAKQIPPALLEELDALNLAEPWKTILNSESLKTHRVFHWTTRCVYITQDDARRAGEQGVIFVGDSWHAMPIFGGEGGNHALLDGVELADAIAASTASSGNGDWDSVIKNYYGGAWKRSQEAVRRSTQRFFLLHRPATEWKEISEQKKKPA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997).  The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity).  The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity).  The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity).  The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity).  Neosartoricin B can be converted into two additional compounds neosartoricins C and D (PubMed:23758576).  Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (PubMed:23758576).  On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (PubMed:23758576).  Both of these compounds are novel and possibly represent related metabolites of the gene cluster (PubMed:23758576).
What are the official names of this protein?
FAD-dependent monooxygenase nscC, Neosartoricin B biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: DCK1_FOWPN
Sequence: MDSINEFTSKKLSIEGNISSGKTDVLNILRNINNVVSFHDVEDRYTPIEKELIRKFHENPSRWSYALQTHYCMKRVRMHLECFVPSRVNILERSIFSDRYVFAEAATALGYMDDPEWALYCKQHDWYTDKLEIQFDGIIYLRTIPESCKERINEKSITEKNYPNISIDYLKTLHEKHELWLTQCKKVPVLIIDGEEDFIFDPCAKKKLINEVTEFINSI
What are the official names of this protein?
Probable deoxycytidine kinase FPV059, dCK.
What is the protein family that this protein belongs to?
Belongs to the DCK/DGK family.
Protein: SECA_SHESA
Sequence: MFGKLLTKVFGSRNDRTLKGLQKVVNKINALEADYEKLTDEQLKAKTAEFRERLAAGASLESIMAEAFATVREASKRVFEMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNALTGKGVHVITVNDYLARRDAENNRPLFEFLGLTVGINVAGLGQQAKKDAYNADITYGTNNEFGFDYLRDNMAFSPQERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKINTLIPSLIRQDKEDSEEYVGEGDYSIDEKAKQVHFTERGQEKVENLLIERGMLAEGDSLYSAANISLLHHVNAALRAHTLFERDVDYIVQDGEVIIVDEHTGRTMPGRRWSEGLHQAVEAKEGVRIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVRKDMADLVYLTANEKYQAIIKDIKDCRERGQPVLVGTVSIEQSELLARLMVKEKIPHQVLNAKFHEKEAEIVAQAGRTGAVTIATNMAGRGTDIVLGGNWNMEIEALENPTAEQKAKIKADWQERHDAVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASDRVSGMMKKLGMEEGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVYAQRNELMDAESIEDTIKNIQDDVISAVIDQYIPPQSVEELWDVPGLEQRLQQEFMLKLPIQEWLDKEDDLHEETLRERIITSWSDAYKAKEEMVGAPVLRQFEKAVMLQTLDGLWKEHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQLLSTLKHDVISVLSKVQVQAQSDVEEMEARRREEDAKIQRDYQHAAAEALVGGDDGSDEMMAHTPMIRDGDKVGRNDPCPCGSGRKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: S35B3_HUMAN
Sequence: MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNSRKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV
What is the function of this protein?
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi.  PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi.  Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.
What are the official names of this protein?
Adenosine 3'-phospho 5'-phosphosulfate transporter 2, 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPS transporter 2, Solute carrier family 35 member B3.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: DPO3B_ECOL6
Sequence: MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T23O_HERA2
Sequence: MSQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLRANDTGRANQSIRRILTILKTIVAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFVLGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQLNGYAIPSEQIGRDVTQSLVASPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAAYLASTIKPFFPDLWAIRADL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: LEU3_STRGG
Sequence: MSRSIDLAVIPGDGIGQEVVAQGLKVLNAVLPQDVKLETKEYDLGAQRWHRTGDTLPDAELEALKGHDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHFINLRPSKLFPNTATPLAGRPDIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSLNTAYGVERVVRDAFERAAARPRKKLTLVHKNNVLVYAGHLWKNTFDKVAAEYPQVSTDYLHVDAATIFFVTQPERFDVIVTDNLFGDILTDLAAAVSGGIGLAASGNINPTGAFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLRHLGYEAEAARIEDAVSADLAERDGSVARTTDEIGDALAVRVAS
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_CULQU
Sequence: MNRRLPATLRELSECFRSKSLDPLTFTEHTLHRASDRAKHLNAFVRISSQTALQQAEASTQRHRSGSTLGPLDGATIAVKDNFCTRNVATTCASRMLESFVPTYSATVWERLERGGAVLVGKTNMDQFGMGSGTVDSIFGPTRNCWSESLEGERFRIAGGSSGGSAVAVASGVCFAALGSDTGGSTRNPASYCGVVGLKPTYGLLSRHGLIPLVNSMDVPGILTRTVKDCATVLNAIAGPDERDSTTVKKPFKPVELPESICLKGLRIGIPVEYHCEGLSEEVLHTWAKVADMLEDAGATVTSVSLPYTSASIFVYSILNQCEVSSNMSRYDGIEFGLRSDEDASTEQLYARSRAEGFNGVVKNRILTGNYFLLRKNYDKFFQKALQVRRLIAEDFDKAFTKVDFLLTPTTLSSAPLYEDFVQGTNRDQCAVQDFCTQPANMGGIPAISLPIRLSEHKLPISLQLMGPNFSEQNLLTVAKWIESQVEFEHLCATND
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, Glu-AdT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GLPG_ECOSE
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVVMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y138_META3
Sequence: MEKLSFEEGKFAVKFARINIECYLSGVHYVVDDLPPIFKKPRGVFTTLYTYPKRNLRGCIGIPEPVMPLIDALKEASISASVDDPRFPPVGRMELRDITIEISILTPPKLVEANSPADYLEKIKVGRDGLIIEYGTYRGLLLPQVPIEHNWDIGEYLANLCLKAGLPVDTWIKKKVNIYSFESQIFKELSPNGKIVEEK
What are the official names of this protein?
Protein Maeo_0138.
Protein: QUEC_BURP6
Sequence: MIRTDAKDGALVLFSGGQDSATCVAWALERYQTVETLGFDYGQRHRVELECREGVRDALKRRFPQWSHKLGDDHLIDLSVLGSISDTAMTRAIEIETASNGLPNTFVPGRNLLFMTIAAAIAYRRGLRALVGGMCETDFSGYPDCRDDTMKALQVALNLGMDTRFVLETPLMWLDKADTWRLAEQLGGAPLVELIRVETHTCYVGERSELHDWGFGCGECPACKLRKRGYDAYLRGESVTEAPA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: HP1B3_RAT
Sequence: MATDMSQGELIHPKALPLIVGAQLIHADKLGEKADDSTMPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPENETPPAPSREAEQPKGEPESGEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSEDEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRGKVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKKKSFKTKK
What is the function of this protein?
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity.  May play a role in hypoxia-induced oncogenesis.
What are the official names of this protein?
Heterochromatin protein 1-binding protein 3.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
Protein: PYRB_AGRVS
Sequence: MVFFPHRHLIGIKGLTETDITYLLDKADEAVKISRQREKKTSTLRGLTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMHPDVLVVRHASAGAAALLSQKVACAVINAGDGQHEHPTQALLDALTIRRAKGKLSRIIVAICGDVLHSRVARSNILLLNAMGARVRVVAPATLLPSGIADMSVEVFHDMKEGLKDADVVMMLRLQRERMAGSFVPSIREYFHFYGLDAEKLKAAKEDALVMHPGPMNRGVEIASDVADGPQSVIESQVEMGVAVRMAVMESLLISDNNGPRSEGVGA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.