PharMolix/UniProtQA huggingface dataset:
Protein: CLCN3_RAT
Sequence: MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGVVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
What is the function of this protein?
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634).  May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321).  It could help neuronal cells to establish short-term memory (PubMed:8155321).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Note=In hepatocytes found in the canalicular membrane. SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=In hepatocytes found in the canalicular membrane.
Protein: SPDLY_HUMAN
Sequence: MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPETQCPQQ
What is the function of this protein?
Required for the localization of dynein and dynactin to the mitotic kintochore.  Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.  Also required for correct spindle orientation.  Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067).  Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin.  Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).  Plays a role in cell migration (PubMed:30258100).
What are the official names of this protein?
Protein Spindly, hSpindly, Arsenite-related gene 1 protein, Coiled-coil domain-containing protein 99, Rhabdomyosarcoma antigen MU-RMS-40.4A, Spindle apparatus coiled-coil domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the Spindly family.
Protein: DDB1A_ARATH
Sequence: MSSWNYVVTAHKPTSVTHSCVGNFTSPQELNLIVAKCTRIEIHLLTPQGLQPMLDVPIYGRIATLELFRPHGEAQDFLFIATERYKFCVLQWDPESSELITRAMGDVSDRIGRPTDNGQIGIIDPDCRLIGLHLYDGLFKVIPFDNKGQLKEAFNIRLEELQVLDIKFLFGCAKPTIAVLYQDNKDARHVKTYEVSLKDKDFVEGPWSQNSLDNGADLLIPVPPPLCGVLIIGEETIVYCSASAFKAIPIRPSITKAYGRVDVDGSRYLLGDHAGMIHLLVITHEKEKVTGLKIELLGETSIASTISYLDNAVVFVGSSYGDSQLVKLNLHPDAKGSYVEVLERYINLGPIVDFCVVDLERQGQGQVVTCSGAFKDGSLRVVRNGIGINEQASVELQGIKGMWSLKSSIDEAFDTFLVVSFISETRILAMNLEDELEETEIEGFLSQVQTLFCHDAVYNQLVQVTSNSVRLVSSTTRELRDEWHAPAGFTVNVATANASQVLLATGGGHLVYLEIGDGKLTEVQHALLEYEVSCLDINPIGDNPNYSQLAAVGMWTDISVRIFSLPELTLITKEQLGGEIIPRSVLLCAFEGISYLLCALGDGHLLNFQMDTTTGQLKDRKKVSLGTQPITLRTFSSKSATHVFAASDRPTVIYSSNKKLLYSNVNLKEVSHMCPFNSAAFPDSLAIAREGELTIGTIDDIQKLHIRTIPLGEHARRICHQEQTRTFGICSLGNQSNSEESEMHFVRLLDDQTFEFMSTYPLDSFEYGCSILSCSFTEDKNVYYCVGTAYVLPEENEPTKGRILVFIVEDGRLQLIAEKETKGAVYSLNAFNGKLLAAINQKIQLYKWMLRDDGTRELQSECGHHGHILALYVQTRGDFIVVGDLMKSISLLLYKHEEGAIEERARDYNANWMSAVEILDDDIYLGAENNFNLLTVKKNSEGATDEERGRLEVVGEYHLGEFVNRFRHGSLVMRLPDSEIGQIPTVIFGTVNGVIGVIASLPQEQYTFLEKLQSSLRKVIKGVGGLSHEQWRSFNNEKRTAEARNFLDGDLIESFLDLSRNKMEDISKSMNVQVEELCKRVEELTRLH
What is the function of this protein?
Component of light signal transduction machinery.  Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s).  Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1.  Plays a role in DNA repair by forming with DDB2 the UV-damaged DNA-binding protein complex (UV-DDB).  Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DNA damage-binding protein 1a, UV-damaged DNA-binding protein 1a, DDB1a.
What is the protein family that this protein belongs to?
Belongs to the DDB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus upon exposure to UV (PubMed:18551167). Excluded from the nucleus when in complex with farnesylated ASG2 (PubMed:26147561).
Protein: BL1S1_ZYGRC
Sequence: MAPKYELDQLVNSICKSTRDTDASKILKEIEDNNSYITEVQLKRLLKLHDGSFRESLTPLQKLHDKYNEIVMRQGDLQSWAELIDRDLRVLELTMQLAKRR
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit BLS1, BLOC-1 subunit BLS1, BLOS1-homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: RBFA_MYCUA
Sequence: MADPARARRLAKRITTIVASAIEYEIKDPGLVGVTITDAKVTADLHDATVYYTVMGPTLDGEPDYAAAAAALERAKGVLRTKVGAGTGVRFTPTLTFTRDVTSDTVHRMDELLARARAADADLARVRVGAKPAGEADPYRDRGSVDEPSDAGGLVIRTSDGLEAENTGDDYQAED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1039_BURO0
Sequence: MPPMTRKTRIQPIEPVAEEDDNGYDRPSKSQLKREMHELQVLGQALVDLPKDALKRMPMPESLGDAVREARRITDHEGKRRQLQYVGRVMRSLTDDETAALRTALDAQRGVNKAATARLHWIERTREQLLASDDALTEFLRQHPDADIQEGRTLIRNARKEAQQGKPPRYFRELFQWIKAAGGASDSDDEAADDAGDDHDDDEA
What are the official names of this protein?
UPF0307 protein Bcenmc03_1039.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: PROQ_IDILO
Sequence: MSEPEKLTKSKDVIAYLAEQFPDCFTIKGDAKPLKIGIFEDLAKRLEDDDKVSKTRLRTALRHYTNSWRYLYSVKTGAQRVNLDGEQVEAVTEEHQQHAQETLKESKAKVAEKNKATNKAAAKKAPAKDKPENTAKAKPKTAKKPAKPKVKLADVELNKLSVGQQVQVKAGNTPMSATVLELDKDDVQVQLQNGLIMKVKADKIFLRA
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_METKA
Sequence: MRLKRLSTNHLLSIADLDREDVETVLRVAERFKERYLAGERVIPILEGKTLGLIFEKPSTRTRVSFEVAMHQLGGQAFTYTKQELQLGRGEAIKDTAAVLSRYLDGVMIRARRHEDIEEFARYSEVPVINGLSDLEHPCQALTDAFTIREKLGRGPHTVAFVGDGNNVCSSLALVCATLGWDFVHAVPEGYECPDRVWREVERRAEESGSETRVVRDPKEAVREADVVYTDVWVSMGDEAEREERLRVFRPYQVNEELMSHAPEHAIVMHCMPIQRGYELTDDVADSERSVIYDQAENRLHVQKAILALLMG
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK2_RAT
Sequence: MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase isoform type-2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2, Methionine adenosyltransferase II, MAT-II.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: SEC16_ASHGO
Sequence: MSTEAKRRRNQKKKQKQKQKKAAEKMQEQASLESTLGSPIDVSIFEQQQYGGAEDAEAAGAAAARESADESRGASVESSGSTDNAIGDDRAGSAPSPYVAVGDSAAVSTAVEVSAPLQDEAFSAVDVEATESPASALPAASVEESEHVSIATPAEPSAAPVAPEAAASEENVVQMAGENGTNPEADVPIEDESNFLFGDSPHSPLPWDDGGASDPEQRPEMTEERPELPTFEEERTQHTSLLPSTSNEHKTPQEALSSEEDQAAEPEQNIGVCDGHAEDSTVDVEWEQHTSSSELFGEEHDTPHSPLPWEEQEAAAPEENRSRMEEHKESISGDERDQDVPITEDSAKTGSLPEDTVPGENTPGDIPETATSAKNVDFDSANGTGNVPVESQAHSTTHTPEEYAADSNSLFALEDDGGDFLAELSNGHDVSSQSAADMLPIDDNVPRTTFDGADALAGPAETYEPGDLFADEDTAEEPPWAQNTNPNVDTSQQLPVSRSSAELSSSQAAKETPGIEVPPPMFWDEESDSIEASNDQLAFTPVAQRGKVTLPDKKFSFLDNDDDLLNDDEEEEANAGDQPENDQENCDDDSFLDSDEEPPLLPPKAGKTTYTPSTQVLGQDRSSYDAHNLSSSMAVSPAVAAVTGQQQFLPGPPVPEKPKVGKYALPKQPNPPPQTNKGYYAPTLGGVGLEATDKPPVLSVNDESVRRLEEEKKKSDAYDFPLELVKSKPKPAKPVPVPSIPSIVTASQPASRSFSPSDAQPVFSPEKAGITPLKPTVPPVKNPYQPNFDGNYLSLVDAVNSRTSSVQQNPYAPPPVNVGPQVTSEKPYAAYEGAASGSQSQHPFPPQPLGAYGTNAPKPPLNSYNLAAAQMDSPKERRPAAYVNTSRTRAISNASVGSSGSYNSHQLPAGPTVVPPRFAFPPPQAHISPTIPALQTVGIAGAPPAVSSPGTQRRTHARSHSSVYAPANAPHASKYAPTVHPSVQQKYPSVAGPSKRSLAGNGVPDGVSNRVLPPTIQEVPVDGHALNFRQFPLFNWSQTSKIVYGLSLPIDTGNYMLGKPFPVSGIHVRNSESILVPNVILKDFPGPLIKGKTRTKDLEKWLELSIAYQRESLPGRDLTLWYVLKHKLSTSGSLRELSKILYDSDQLIPYMGQMHSHGRPTLLSHKLDPNSQMQILAHLQVGSPGAALDLALAQKDYALALVLSSLIGKDKWSEVVDTYLREEFSVSAGNNQFSVYLLALIFQVFVGNSNRVLQELTANPLKRDWAIQDWNIILAAVLNNIPKDVDPRQLPPVVMEFLVGFGVFLVQSGKLAAGAVCFVIANVPLSQNELLPHSGVKFECLGSINSLDAVLLSEVYEYYYTTINDNCPFFASLLLMKTVHASALLDYGLPTTVPKYLDVITGLLRNAPKNSAIAVSLTHQLESINLRLSGVTTAWIGKPTLSSVWGQLDKSFNKFIGGDADDFSKQPEKTVFDSFTPSASRNASMVDLNHGVTPMRPSAIKNSGVNRSHTDLPVSNKGGYAPLNAPGSNVFSVSRSNNHPHGTEHGNSMSNLHGDSQHLTHKTNYTPHRASNLISPKYPEEPQNSHLPNQQSNLPSPANGHSRNPSIPSVATPPPIFSAPPKRARGKYAATASGAVSVDQLYSDAGHSNTPTKVKSVPTCPEIAETPAALATRQATDSMTDFFAPPLLQAGLQQDRRSSAYSASSQGILPSSRRSSNISDVMLPPKKSGSGKPYRKTTVNYTPIDMEASSLAPSSVSLSQSTGDTTTEVKRARNSGEASNSSATEVADSTVLHKSPESVDTSEYSFPDESVQSWEENAEDDQDPLHTVSAISNTEVPVDKRDGERGSQNTLTKAAPYSDLAPYEHEGNAPSTESPAIKGSRVQVQVQVTPPEDFAHIQSQVVSPEKEASPTVEKGANANESSPDLHERQPYAGLGVSYNPNTGGPRPFASHQYLPRAPAVPAYSPIEENAAEEGRTDNQTKAVEKQEHAVLKRTVSGPVIGSEKLMSPALAHPIPRTSRFEPIKEIIQNDEDTFRKDKVPVIRASSNPNFNPYTPVASEQYYDDVVEDESDDSEEESERKRQEKEKEEERKREAAEKEKRKNEGGGSSRWFGWLKKDTNEKKPIKAKLGQKNNFYYDEKLKRWVNKDATEEEKQKVSTPPPPPPVVKRKMNTTPEIKPRSGSVVGGPAIRTQGAVAPVNPQDPQPCQAVVGASSALQKQASPVKPRDPAINLTSKKANGLDDLISLTAGPSNAVSRRKKKPGRGYVNVLNNL
What is the function of this protein?
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules.  Also involved in autophagy (By similarity).
What are the official names of this protein?
COPII coat assembly protein SEC16, Protein transport protein SEC16.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ZAPB_ENT38
Sequence: MTMSLEVFEKLESKVQQAIDTITLLQMEIEELKEKNNALAQEVHSAQNGREELERENQQLREQQNGWQDRLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: QUEC_LEPBP
Sequence: MVSILDSSFKSKTEKKGAIVLLSGGLDSTTCLYLAAKDFGYPKNKKLPLLALSFDYSQKHKIELTKSKKIAKTLGIKHVIQKLDPGFFLGSSLTESKIKVRKNAKSLFSGDETEIPNTYVPGRNILFLSFALSLAEGHGYDSIYIGVNALDYSGYPDCRPEFIDSFQKMANLGTKKGVSGTGDSIQIKTPLLHLGKKEIIELGMSVGAPLGLTHSCYDPVSGKPCGKCDSCILRAKGFLEVGLKDPAL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: KAD_STRSV
Sequence: MNLLIMGLPGAGKGTQAAKIVDHFNVAHISTGDMFRAAIANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQNDIKETGFLLDGYPRTIEQAHALDQTLTELDLALDGVINIEVDPNSLLERLSGRIIHRETGETFHKVFNPPADYKEEDYYQREDDKPETVKRRLDVNIAQGQPIIDHYRRKGLVHDIQGNQDINDVFSAIEKVLTNLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF5A2_HUMAN
Sequence: MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK
What is the function of this protein?
mRNA-binding protein involved in translation elongation.  Has an important function at the level of mRNA turnover, probably acting downstream of decapping.  Critical for the efficient synthesis of peptide bonds between consecutive proline residues.  Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity).  Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.  Functions as a regulator of apoptosis.  Mediates effects of polyamines on neuronal process extension and survival.  May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-2, eIF-5A-2, eIF-5A2, Eukaryotic initiation factor 5A isoform 2.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Protein: RL4_METPP
Sequence: MELELLNEQGQAASKVDAPDTVFGRDYNEALVHQVVVAYQANARQGTRAQKDRQTVKHSTKKPWRQKGTGRARAGMTSSPLWRGGGRIFPNSPEENFSHKVNKKMYRAGMAAIFSQLAREGRLAVVDSIKVETPKTKALAAKFKAMGLESVLVIADEVDENLFLASRNLANVLVIEPRYADPLSLVFYKKVLVTKGAIEKLKEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RNH2_SHESR
Sequence: MAVFKTLTDADMAIFSTGLVAGVDEVGRGPLVGDVVTAAVILDPNRPIAGLNDSKKLTEKRREALFDEICEKALSFHVGRASPAEIDELNILHATMLAMQRAVAGLSLTPELVLVDGNRSPAFNHAGQALTSHSIVKGDGLIASISAASIIAKVTRDREMDALDAAYPQYGFAKHKGYPTKAHFDAIAEHGVFDQYRKSFKPVKALLER
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDT4_MOUSE
Sequence: MKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPTNGNSSVPSLPDNNALFVTAAPPSGVPSSIR
What is the function of this protein?
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (By similarity).  Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (By similarity).  Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity).  Does not play a role in U8 snoRNA decapping activity (PubMed:16141072).  Binds U8 snoRNA (PubMed:16141072).
What are the official names of this protein?
Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DIPP subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_OENOB
Sequence: MDLSKLTTEARNKRTMNLDRMTIHEFATIMNQEDQSVPLSVANSLATIENAIDSITKHFKQGGRLFYIGAGTSGRLGVLDAVECVPTFGIEAEMVRGLIAGGPSAMTLAVEGAEDDDKLASSDLKKRALTAADVVVGIAASGRTPYVIGGLDYADSLGAATISLACNQNSEISKHAQIAIEVPVGPEILTGSTRLKAGTAQKLVLNMLSTGAMVGIGKVYKNLMVDVRPTNEKLLIRSKRIICQATNCDEATAAEVFEKADRNVKLAIVMILTNLPKKEANEQLRKADGFISKTIPE
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: LRTM2_MOUSE
Sequence: MLAPGGGPEQRSKLVLQWRQVSWITCWIALCAVEVIPACPFSCTCDSRSLEVDCSGLGLTTVPPDVPAATQSLLLLNNKLSALPSWAFANLSNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQSLDRLTFEPLASLQLLQVGDNPWECDCNLREFKHWLEWFSYRGGRLDQLACTLPKELRGKDMRAVPMEMFNYCSQLEDENNSAGLDAPGPPCTKASPEPPKPKPGAEPEPEPSTACPQKQRYRPVSVRRAIGTVIIAGVVCGIVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEHEDQKQISSVA
What are the official names of this protein?
Leucine-rich repeat and transmembrane domain-containing protein 2.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TRUB_STRP3
Sequence: MINGIINLKKEAGMTSHDAVFKLRKLLQEKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTEAGKVYEGQVTLGYSTTTEDASGEVVARSSLPAVLTEELVDQTMTTFLGKITQTPPMYSAVKVNGRKLYEYARAGESVERPRREVTISLFERTSPLNFTEDGLCRFSFKVACGKGTYVRTLAVDLGRALGVESHMSFLQRSASAGLTLETAYTLGEIADMVSKQEMSFLLPIEYGVADLPKMVIDDTELTEISFGRRLSLPSQEPLLAAFHGEKVIAILEKRDQEYKPKKVLI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: DIUH2_TENMO
Sequence: AGALGESGASLSIVNSLDVLRNRLLLEIARKKAKEGANRNRQILLSL
What is the function of this protein?
Stimulates fluid secretion by the Malpighian tubules.  Increases cyclic AMP production in Malpighian tubules.
What are the official names of this protein?
Diuretic hormone 2, DH(47), DH47, Diuretic hormone II, DH II, Diuretic peptide II, DP II.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: METXS_PSYA2
Sequence: MNSVGVVKPQTLHFAEPLTLECNRTLPSFELIIETYGTLNSDKSNAVLICHALSGSHHAAGFHSDNDKKAGWWDNMIGPNKSIDTNRFFVVCVNNIGSCFGSTGPTSINPESSKAQVYGPDFPLVTIKDWVKTQAMLSDRLEIDVWHAVVGGSMGGMQALQWAADYPSRLKRCVVIASTPKLSAQNIAFNEVARQSILSDPDFKNGRYLQAGTYPRRGLILARMVGHITYLTDDAMKAKFGRDLKSGKFMYGYDVEFQVESYLRYQGERFSENFDANTYLLMTKALDYFDPTRDYPLTQSAQPIDSLVPEELLASSLVESVKADSSEDELAKTLADSADIDNISASNHQELTALKAAFAHTECQYLIVSFTTDWRFAPERSQEIVDALMATGKPVSYINVDAPHGHDSFLFDIPRYMGAVKGFLNAPFMTDNQSKNSQQKLGARS
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_STRM5
Sequence: MARSRSRIDRTPFQTEILDLSHDGRGVARREGEGGKVTFVSGALPGEVVMAEQTARSRHFDEARTVEVLKASPQRVTPKCPHFGTCAGCVLQHLDEDQQIVAKQRVLMDNLERIGHVKPGTVLAPLVGESWGYRRKGRFSVRRVEKKDKTLVGFREQDPRFVADLSQCLTVIPEIGTKVEALSTFIESLDGKRDIPQIEFIAGDQAVVLTVRHLQPLSDADRAAWATFGQQHGFVIYLQSGGVDTVQPLDGQGVPLSFRLAPWDVELAFRPLDFIQVNAKLNEKMIAHALDLLEPGEDERVLDLFCGLGNFTLPLARRVREVVGVEGDAGLVARARENAERNGLANAQFFSADLTQDQRSTAWMRQGFDKLLLDPPRSGAIEVLQQLPLKQFKRIVYVSCHPGSLARDAGYLVNEQGFTLVSAGAMDMFPHTAHVESIAVFEKR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.