PharMolix/UniProtQA huggingface dataset:
Protein: O162_CONAH
Sequence: MKLTCVVIVAVLFLTAWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDECYPPGTFCGIKPGLCCSERCFPFVCLSLEF
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.
What are the official names of this protein?
Delta-conotoxin-like Ac6.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_SYNC1
Sequence: MKMILLGPPGSGKGTQAKMLSERLGIPQISTGDMLRAAVKEGTPMGVKAKAKMDAGALVPDEVVVGIVRERLVKDDCDKGFILDGFPRTLPQADALKQTLGDLKKDLDAVISLEVDNDAVVGRVAGRRTCRDCGKMYHVEFDAPAVADKCDKCGGQLFQRDDDKEETIRKRLDVYAQQTAPLIAYYRADGLLRDIDGMKDISGVQQQILSALGCGL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CR025_PONAB
Sequence: MKMEEAVGKVEELIESEAPPKASEQETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRVYESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSRSESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDSSTSDSDLTCDSSTSSSDDDEEVSGSSKTITAEIPETGFCYVVQAGLGLLGLSDLHTLASQSAEILWDSHLA
What are the official names of this protein?
Protein C18orf25 homolog.
Protein: NTPC_ENTHA
Sequence: MEYHELNPLIRGRELELISKDTFEQMIQTDSIDSLGEILQSTIYQPYIYDGFDKDFEANLSQERSKLFQWLKESAPEPEIVWIYTMRYTFHNLKVLTKAEITGQNLDHLYIHDGFYSLEVLKDAIHTQVSVELPDSLMDYIREVHEYCEESTILQGIDVIYDRCFLTEQRRLGEQLGYPELLEEIIAFIDLTNITTTARGILQHRSAGFMTTVISSSGSIPKDTLLSFVRGEMASFTQFLLTTDYSELLKQVIHEEQIDLVSLEQLKDDYLSSFYQVAQTQAFGPLPLLAFLNAKEVESKNLRLLIIGKRNHFSLEQLKERMRQVYDL
What is the function of this protein?
Involved in ATP-driven sodium extrusion.
What are the official names of this protein?
V-type sodium ATPase subunit C, Na(+)-translocating ATPase subunit C, V-type sodium pump subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: TMM17_MOUSE
Sequence: MELPDPVRQRLSNLSLTVFGDSSRTGPESSDAADNEMVSSLALQMSLYFNSYFFPLWWVSCIVMLHLKYSILPDYYKFIVVTVVILITLIEAIRLYLGCMGNLQEKVPELAGFWLLSLLLQLPLILFLLLNDGLRNLPLEKAIHIIFTIFLTFQVISAFLTLKKMVNQLAARFHLQDFDQLSSSSAAVRRVRQCTEEL
What is the function of this protein?
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for ciliogenesis and sonic hedgehog/SHH signaling.
What are the official names of this protein?
Transmembrane protein 17.
What is the protein family that this protein belongs to?
Belongs to the TMEM17 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Note=Localizes to the transition zone of primary cilia.
Protein: FIBA_HORSE
Sequence: TEEGEFLHEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: DGTL1_LEPIC
Sequence: MYFSRDDLLQKETETLAPYAISNANNGGRIYEEEEHSYRLPFQRDRDRILHSSAFKRLQYKTQVFIFSVGENYRNRMTHTLEVAGLSRTIASALGLNSLLSESIALAHDLGHTPFGHAGQEILSGLMKDYGGFEHNKQSLRIVTSIEKKYPNFPGLNLCRETLKGLMKHGADYDSSVILLERKENGPSLEGMIADLSDEIAYTNHDIEDGWEMGYLHLGDLLENPFWKEVYEECKDQYKEVGEKILIRTSIRTLTNFLVSDLIQNIAHRLEKKQIKSTEDLALLWKQDFRIASFSKEVDLKFRELKSFLYEKLYRHEDLIRMSDYGKKIIESLFDYFLKHPEKIPDTYKERIEEESLYRVISDYVAGMTDRYAEKIYQSLP
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: LPXD_BURO1
Sequence: MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPRNFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMADTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIYTSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: SUCC_WOLSU
Sequence: MNIHEYQAKALLAQYGVGIPRGGVAETPAEATVIAQRLGGEIWAIKAQIHAGGRGKAGGVKLAKTPEEAGEIAKAMLGSRLITHQTSLEGKEVHKVYVEEGLGIEREYYLGIVLDRSLEMPVIMASRQGGVDIEEVAKNSPNEIIKVAVDPMIGFRPFHGRKLAFALGLAKEQVGLFVDFCTSLFRLYVQKDAEIVEINPLVFTSCKRFVALDAKISFDNNALYRHPEIVAMRDLSEEESSEIEAGEYNLNYVKLQGNVGCMVNGAGLAMATMDIIKHEGGEPANFLDVGGGAKPETVAKGFEIILKDPNVKAIFVNIFGGIVRCDRVANGILEAAKIVHVSVPVVVRLDGTNAKEAKEILEQANIPNIFAAPSLEGGAKKAVELACQGGAS
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SPI1_PIG
Sequence: MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMAPTHASLGHQVSYLPRMCLLYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGALVVRRHPPH
What is the function of this protein?
Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites.  Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity).  Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity).  Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors.  FCER1A transactivation is achieved in cooperation with GATA1 (By similarity).  May be particularly important for the pro- to pre-B cell transition.  Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity).  In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
What are the official names of this protein?
Transcription factor PU.1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIBB_METLZ
Sequence: MFTFNTIEEALKSLQNGEMIIVTDDENRENEGDLICAAEYATTENVNFMAKYGRGLICMPMGRSLVEKLCLPPMVLKNTDNHETAFTVSIDHVDTTTGISAVERGITARKCIDPNARPEDFRRPGHMFPLQAKDNGVFEREGHTEATVDLMKLAGLREAGLCCEIMADNGEMMRTPELISMAKQYNLTFVTIKDLQAYRRKQEASALAVEQKNMSPMDC
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: RS8_METM7
Sequence: MSLMDPLANALNHVSNCESVGKNVAYLKPASKLIGRVLNVMQDQGYIGNFEYIEDGKAGVYKVDLIGQINKCGAVKPRFAVKNHDFEKFEKRYLPAKGFGLLIVSTPKGLMTHDEARNAGVGGRLISYIY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RSTB_ECOLI
Sequence: MKKLFIQFYLLLFVCFLVMSLLVGLVYKFTAERAGKQSLDDLMNSSLYLMRSELREIPPHDWGKTLKEMDLNLSFDLRVEPLSKYHLDDISMHRLRGGEIVALDDQYTFLQRIPRSHYVLAVGPVPYLYYLHQMRLLDIALIAFIAISLAFPVFIWMRPHWQDMLKLEAAAQRFGDGHLNERIHFDEGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALNRDISQLEALIEELLTYARLDRPQNELHLSEPDLPLWLSTHLADIQAVTPDKTVRIKTLVQGHYAALDMRLMERVLDNLLNNALRYCHSTVETSLLLSGNRATLIVEDDGPGIAPENREHIFEPFVRLDPSRDRSTGGCGLGLAIVHSIALAMGGTVNCDTSELGGARFSFSWPLWHNIPQFTSA
What is the function of this protein?
Member of the two-component regulatory system RstB/RstA.  RstB functions as a membrane-associated protein kinase that phosphorylates RstA (Probable).
What are the official names of this protein?
Sensor protein RstB.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OLF50_MOUSE
Sequence: MMKSNQSTVSEFILLGLPIQPEDQAVYFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDISFSSVTAPKMLMNMLTHSQSISHAGCVSQIYFFLLFGCIDNFLLTSMAYDRYVAICHPLHYTTIMSQSLCVLLVMVSWAFSSSNGLVHTLLFARLSLFRDNTVHHFFCDLSALLKLSSSDTTINELVILTLAVVVITVPFICILVSYGHIGATILRTPSIKGICKALSTCGSHLCVVSLYYGAIIGLYFFPSSNNTNDKDVIVAVLYTVVTPMLNPFIYSLRNRDINGALRKTLSRRLCSH
What is the function of this protein?
Odorant receptor.  Activated by (+) and (-)-carvone.
What are the official names of this protein?
Olfactory receptor 50, Olfactory receptor 136-6, Olfactory receptor I-D3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TX1_STRCF
Sequence: DCTRMFGACRRDSDCCPHLGCKPTSKYCAWDGTI
What is the function of this protein?
Acts as a gating-modifier to inhibit voltage-gated potassium channels.  It inhibits delayed Kv2. 1/KCNB1 (IC(50) is 12. 7 nM), Kv2. 1/Kv9. 3 (IC(50) is 7. 2 nM) (KCNB1/KCNS3), Kv2. 2/KCNB2 (IC(50) is 21. 4 nM), and transient Kv4. 2/KCND2 (IC(50) is 1. 2 nM) channels.
What are the official names of this protein?
Kappa-theraphotoxin-Sc1a, Kappa-TRTX-Sc1a, Stromatoxin-1, ScTx1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 57 (ScTx1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y496_PROA2
Sequence: MSGHSKWSTIKRKKAATDQKRGNLFTKLVREITIAAKMGGGDPSGNPRLRLALDNARANSMPQENIQRAIKKGTGELDGVVYEEITYEGYGPGGIALIIETATDNRNRTVADIRHIINRSNGSLGENGSVSWMFHRKGCIDVLKSSAGEEELMEILLEAGLEDLNTDDEQFYNVIIDVKDLESAKKALDDKGIAYENARMDMIPDNYVELEAEDAVKAVKLIDALENSDDVQVVYSNIEFSEQAMNSLDS
What are the official names of this protein?
Probable transcriptional regulatory protein Paes_0496.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_SHESA
Sequence: MAEVANNEQQAPQFNIQRVYTKDVSFETPNSPAVFQKEWNPEVKLDLDTRSAKLADDVYEVVLSLTVTAQNAGETAFLCEVQQAGIFSIAGLTEPQLAHSLGAYCPNILFPYAREAVGSLVGRGTFPQLNLAPVNFDALFAQYVQQRQAAAAAPAAEEANA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_LISW6
Sequence: MQLITTENKLAGSKKALEIIEKGITTGEVNTLGLATGSTPETLYAELVKSDVDTTNVTTTNLDEYVGLAASDPNSYHYYMNNLLFSKKAFKESFLPNGEATDAEAECARYEEILTEHPIDIQVLGIGTNGHIGFNEPGTSFDSLTHKVVLTDSTREANKRFFEREEDVPTHAYSMGIKSIMNAKKIILLAFGENKAQAIKETIKGPVDVNCPASVLQNHPDVTVILDNEAASLL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: REPI1_MOUSE
Sequence: MLEQRCRGPTAMGPAQPWLFSGPSQESSQPDRGLRYQGKSAQPRGQTPGKVHRCAHCRKRFPGWVALWLHARRCQARLPLPCHECNQRFRHAPFLALHLQVHASAVPDLGFICHLCGHSFRGWVALVLHLRAHSASKRPITCPECDRRFWRQKQLRAHLRRCQPPVPEARPFICGNCGRSFAQWDQLVVHKRVHVAEALEEAAAKALGPRPRGRPAAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRLEVSAQAAPHPESHQIAAEPMAQPALGVPLGSPRTPAEAPALLHSCSDCGRSFRLERFLRLHQRQHTGERPFACTECGKNFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPERPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKSNLITHRKSHIRDGAFCCAICGQTFDDEDRLLMHQKKHDA
What is the function of this protein?
Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication.  Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone.  Facilitates DNA bending (By similarity).
What are the official names of this protein?
Replication initiator 1, Zinc finger protein 464, Zfp-464.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRDI_RHILW
Sequence: MGLIVYYSSRSENTHRFVARLGLRAARIPAGGADAFHIREPFVLVVPTYSDGDGKGAVPKQVIRFLNDAENRGHIRGVIAAGNSNFGETYGLAGDVISQKCRVPYLYRFELIGTEEDVANVKHGMERFWTREQL
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: PYRF_NEIG1
Sequence: MNPLITDFQTPQQRTPVIVALDFANEKDTLGFVRNLDPALCQIKIGKELFTATGRSLAESLIHQGFKLFLDLKYHDIPHTVAQACKVAADMGVWMVDMHASGGRRMMEAAAEAVAGYGTKPLLIGVTVLTSMEQSDLAEIGLNTAPEEQVIRLAKLAQSSGLDGVVCSAQEAAPLRRELGRDFVLVTPGIRLDVAGNNDDQRRIMTPAEALAAGSTYLVMGRPVTRAADPVAVLREVNRVANLEAN
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CDT1_HUMAN
Sequence: MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
What is the function of this protein?
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564).  DNA replication licensing factor, required for pre-replication complex assembly.  Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932).  Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055).  Potential oncogene (By similarity).
What are the official names of this protein?
DNA replication factor Cdt1, Double parked homolog, DUP.
What is the protein family that this protein belongs to?
Belongs to the Cdt1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Transiently localizes to kinetochores during prometaphase and metaphase.
Protein: EF1B_METST
Sequence: MSDVAAILKVMPESPEIDLEALKETIKNTIDADSFERIEEEPIGFGLIALNVTIVVDDGEGGTEPAEEALAALDEIQSVEVTDVRRLM
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: TIG_GLAP5
Sequence: MSISIETLEGLQRRVTVTVAADKIEAGYKEQLKGYAKNARVDGFRKGKVPHSIIEQRYGLAARQDVLSEEMQRAFFDVVIAEKINLAGRPTFTPNNYQPGQDFSFVATFEVFPEVELKGLENIEVEKPVVEITEADLDKMVDVLRKQQATFAETTEAAKADDRVTIDFVGSVDGEEFEGGKASDFVLAMGQGRMIPGFEEGIVGHKAGEQFDIDVIFPAEYHAENLKGKAAKFAITLKKVENIVLPELTEEFVKKFGSAKTVEELRVEIKKNMQRELKNALTTRVKNQVINGLLANNDIEVPSSAVAEEVDVLRQQAVQRFGGKPEMAAQLPAELFEVEAKRRVQVGLLLSSVITSNELKVDEDRVKETISELASAYEQPAEVVEYYAKNPRLTDNIRNVVLEEQAVEAVLAKAKVTEKASSFDEVMSHQG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: A2372_ARTBC
Sequence: MHSIIFKAAVALLGVSTAAGFSYQNSRLCLKLLAQGVEVDLPNSTDYETEQQNYWSTACTALRPDCIIAPKNARDMSRAVAAIQESKTTRFAIKSGGHSPNQLFSSIHDGVLISTRNLKQITYNEHTQTAVLGPGLKWEEAVGGLKDKGQTVVGGRLGGIGVGGLILGGGLSFLSGQYGWATNNVVNFEVVLANGTIVNANATSNPDLYAVMKGGSGNFGIVTAFTVKTHTQDPEIWGGSMFFDGNHTESLTRAIRDFAEYNTDDKASIIGTVNRNPSLIWVVFLTYDGPSPPEDVFRNFTQIPNIRNTVKRQSYHSLMLANDEYIRHGNRFSIGAETSVNPSGTHGYDIFKSFIDHWNDVTDDFIDIPGSASSLALQPLPRSISTKAKESGGDVAGFDPRYDYLLLQIAVSWNSSTSDSVIEAATRKYYTVQGDMIKQFTNEGKLPKAYCPLYLNDLNANQDFWGRVAPSTREKALAVRRAVDPTLFFQNRVTGGFRLG
What are the official names of this protein?
Uncharacterized FAD-linked oxidoreductase ARB_02372.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL21_ESCF3
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: LSPA_CHLPN
Sequence: MATRFRSTLLVITLFVLIDWVTKLVVLLQYKDLQILTHPTLYTHSWGRFSFSIAPVFNEGAAFGLFSNYKYFLFLLRIFVILGLLAYLFFKKKSIQSTTQTALVLLCAGAIGNVGDIIFYGHIVDFISFNYKQWAFPTFNVADVLISLGTLLLVYKFYFPTKQTEKKR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAA_SHEB5
Sequence: MTSKNSIQKALYLAFERLQWSELRDSVPLTLSEQDLENLRGINEKISLSEVTDIYLPLSRLLNLIVKAKQQRGLVVDEFLGQKPSRSPYIISIAGSVAVGKSTTARILQALLRHWPEHPKVDLVTTDGFLYPLADLKRKGLLQRKGFPESYDMKMLVEFISAVKSGQPHVKAPIYSHVTYDRVKNQHQTVSQPDILILEGLNVLQTGLDSPVDTRRPFVSDFVDFSIYVDAEEPLLKQWYKERFLQFRSGAFSDKKSYFHHYSSLTDDEANTIAANIWDTINGPNLQLNIQPTRERAHLILQKGQDHLMSHVLMRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_AERHH
Sequence: MARYFRRRKFCRFTAENVTEIDYKDIVTLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLALLPYTDLHNK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TPC_HUMAN
Sequence: MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR
What is the function of this protein?
Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria.  It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.
What are the official names of this protein?
Mitochondrial thiamine pyrophosphate carrier, Mitochondrial thiamine pyrophosphate transporter, MTPPT, Mitochondrial uncoupling protein 1, Solute carrier family 25 member 19.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: RL7_STRGR
Sequence: MAKLSQDDLLAQFEEMTLIELSEFVKAFEEKFDVTAAAAVAVAGPAAGGAPAEAEAEQDEFDVILTGAGEKKIQVIKVVRELTSLGLKEAKDLVDGTPKPVLEKVAKEAAEKAAESLKAAGASVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12, SA1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.