PharMolix/UniProtQA huggingface dataset:
Protein: ENV_MMTVB
Sequence: MPKHQSGSPTDSSDLLLSGKKQRPHLALRRKRRREMRKINRKVPRMNLVPIKEKTAWQHLQALISEAEEVLKTSQTPQTSLTLFLALLSVLGPPPVTGESYWAYLPKPPILHPVGWGSTDPIRVLTNQTMYLGGSPDFHGFRNMSGNVHFEGKSDTLPICLSFSFSTPTGCFQVDKQVFLSDTPTVDNNKPGGKGDKRRMWELWLTTLGNSGANTKLVPIKKKLPPKYPHCQIAFKKDAFWEGDESAPPRWLPCAFPDQGVSFSPKGALGLLWDFSLPSPSVDQSDQIKSKKNLFGNYTPPVNKEVHRWYEAGWVEPTWFWENSPKDPNDRDFTALVPHTELFRLVAASRHLILKRPGFQEHEMIPTSACVTYPYAILLGLPQLIDIEKRGSTFHISCSSCRLTNCLDSSAYDYAAIIVKRPPYVLLPVDIGDEPWFDDSAIQTFRYATDLIRAKRFVAAIILGISALIAIITSFAVATTALVKEMQTATFVNNLHRNVTLALSEQRIIDLKLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDFICVTPLPYNATENWERTRAHLLGIWNDNEISYNIQELTNLISDMSKQHIDAVDLSGLAQSFANGVKALNPLDWTQYFIFIGVGALLLVIVLMIFPIVFQCLAKSLDQVQSDLNVLLLKKKKGGNAAPAAEMVELPRVSYT
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp70, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: Y1502_CLOPE
Sequence: MKIAVRGGHNFKAKGALGIIDETIENRKVYKALIKYLNIAGHNVIDVTPGECDVNTDLYLGVQKAEDNNSELFLSIHFDKAYDRYEGALGTGTWIYGRGGKAEIYAKRIVDNLSKGTGLKNRGVKENSKLYELRKTSMPAVLVEVCFCEATEDVRIYREKGPDLIGKLIAEAINEKEIEENIKPEGQEDSLKEKFLKSTNTKAIANLDPRDNPSSIYKDLGEIYKGERIRVLPEICDNKDYLPIIYWKDTTNIESQKVWVSAKQNYLKIDTNATVINVVTELDARYIKSQRSSKMGYVKNGERLYVHKIESGYALGTYFASNGYKTAWFTAKYISLD
What are the official names of this protein?
Uncharacterized protein CPE1502.
What is the protein family that this protein belongs to?
To C.perfringens pIP404 ORF10.
Protein: RL13A_PIG
Sequence: QVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKLTGKFXYLGRL
What is the function of this protein?
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions.  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.  Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.  In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex.  Involved in methylation of rRNA.
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LONB_HALSA
Sequence: MSNESTNDAPPDDDPDDPEPSVDHDDTDGLQDDPADSVDDAGEVDDLENLGSDVGVEGDVSIDEDNAEDDLLGGLRIDDTSDITVPDRLVDQVIGQEAAREIVKRAAKQHRHVMMIGSPGTGKSLLAKAMSRLLPKESLQDVLVYHNPDDSNEPKVRTVPAGKGEQIVDAHKEEARKRNQMRSFLMWIMILLAVGYALLIATPARPLLALLSAAGIYLLFRYTNRGSDAMVPKLLINNADRQVAPFEDATGAHAGAMLGDVRHDPFQSGGMATPSHERVEAGSIQKANKGVLFIDEINTLDVRSQQKLMTAIQEGEFSITGQSERSSGAMVQTEAVPCDFIMVAAGNMDAMENMHPALRSRIKGYGYEVYMDDTIEDTPDMRRKYARFVAQEVEKDGNLPHFAPDAIRELILEAKRRAGRKDSLTLKLRDLGGLVRVAGDIARSEGHDLTQRSDVLEAKKRSRSIEQQFVDNYIQRRKDYELGTTSEEAVGRVNGLAVMGGDSGIMLPVMAEITPAQSQEEGRIYATGQLKEMAEEAVENVSAIIKKFSDENMSEKDTHIQFVQAGEGGVDGDSASITVATAVISALEDIPVAQELAMTGSLSVRGDVLPVGGVTHKIEAAAKAGCERVIIPKANEDDVMIEDEYEEQIEIIPVTHISEVLDVALVGEPEKDSLVDRLKSITGKALDSASDSGTTGGNPSPQ
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Degrades polypeptides processively (By similarity).
What are the official names of this protein?
Archaeal Lon protease, ATP-dependent protease La homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYPH1_CUPNH
Sequence: MNDASSDPGIPGRPGDVVAAAAPREVGALVFRPLEIDTWQEHVIYMHPDCPVCRAEGFSAQARVRVQIGDRSLIATLTLLGAPLLNTGEASLSLSAARTLSARAGDVVHVTHAPALESVRALRAKIYGCHLDSVQLDGIIGDISAGRYADVHIAAFLTACADGRMSLRETVDLTRAMVRSGQRLNWDREVVADKHCVGGLPGNRTTPVVVAIAAAAGLLLPKTSSRAITSPAGTADTMEALTRVTLDSTELRRVVEQVGAALVWGGALSLSPADDVLIRVERALDIDSDAQLVASILSKKIAAGSTHVLIDVPVGPTAKIREDSDLARLDLAMTKVADAFGLKLRILRTDGSQPVGRGVGPALEALDVLAVLQCQPTAPADLRERSLLLAGELLEFCGAIPPGQGRLLAGSLLDSGAAWARFQAICEAQGGLRTPGQAVFRRDVVAARSGIVTSVDNRHVARTAKLAGAPRRQVAGLELHVRAGDEVVAGAPLCTLHAQASGELEYAFSYALAHDPFRIE
What are the official names of this protein?
Putative thymidine phosphorylase 1, TdRPase 1.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: LPXA_ACTP7
Sequence: MRLIDSTAKISPLAVVEEGAQIGAHVEIGPFSVIGKNVKIGAKTIIHSHVVINGHTEIGEQNQIFQFASIGEINQDLKYQGEPTKVIIGNRNRIRESVTIHRGTVQGGGVTRIGNDNLFMINTHIAHDCSIGNRCIIANNGTLAGHVTLDDFVIVGGMSAIHQFVVIGSHVMLGGGSMVSQDVPPYVMAQGNHAQPFGVNLEGLKRRGFDKPAMHAIRNAYKLIYRSGKTIEEAIPEIEQFAVNEPAVQLFLDFFKRSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AN34C_MOUSE
Sequence: MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRQSPPLCTTPSDVELKTSGLASPPSEKDDDFFILQTGHQSGCSTSKVLNEPGSPTRKVSSLKRARLPQLKRLQSEPWGLIAPSVLAAATRQDETHGTSTDNEVIRSINDVTFPKRGPLSRTNSIDSKDPTLFPTVQEQVLKVSASTPASWKAAYEKGQAPHPRLARRGTLPLDQEKSGMCPPGPSTLKDPASLKLLENDLYDLDIQPVGDPPNSMSLESGKGPLDRKKLNSSHLSLFHGSRESLEVVPSTSPTSVRRRPPHLLERRGSGTLLLDRIAHTRPGFLPPLNVNLNPPIPDIRASSKPASPLASGLKSMAPVAPNSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMA
What are the official names of this protein?
Ankyrin repeat domain-containing protein 34C.
What is the protein family that this protein belongs to?
Belongs to the ANKRD34 family.
Protein: PYRC_STAES
Sequence: MKLIKNGKILKNGILKDTEILIDGKRIKQISSKINASSSNIEVIDAKGNLIAPGFVDVHVHLREPGGEHKETIESGTKAAARGGFTTVCPMPNTRPVPDTVEHVRELRQRISETAQVRVLPYAAITKRQAGTELVDFEKLALEGVFAFTDDGVGVQTASMMYAAMKQAVKVKKPIVAHCEDNSLIYGGAMHKGKRSEELGIPGIPNIAESVQIARDVLLAEATGCHYHVCHVSTKESVRVIRDAKKAGIHVTAEVTPHHLLLTENDVPGDDSNYKMNPPLRSNEDREALLEGLLDGTIDCIATDHAPHAKEEKAQPMTKAPFGIVGSETAFPLLYTHFVRRGNWSLQQLVDYFTIKPATIFNLNYGKLHKDSYADLTIIDLNTEKEIKSEDFLSKADNTPFIGEKVYGNPTLTMLKGEVVFEEEK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: Y1131_XANC8
Sequence: MGRGPSIEGRKNASDAKRGKIFTKIIREISVAARAGGGDPSNNPRLRTAMDKGLSSNMSKDVIERAIKKATGELEGVEYEEVRYEGYAPGGVAVIVDCLTDNRVRAVADVRHAFSKCGGNMGTDGSVAFMFKRLGVLSFAAGADEDAVTEAAIEAGADDVVVYPEDGAIDVLTAPDTFAQVKQALATAGFEPAHAEITFRAENDIAVDGDTAVQVRKLLDMLEDLDDVQDVYSNVDQASLGA
What are the official names of this protein?
Probable transcriptional regulatory protein XC_1131.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_CHLAA
Sequence: MDLVQSTINQIGPLDDRAATAARRRQDMLTKPAGSLGRLEELSIRIAGITGRERPRLTNPAVIVMAADHGVARQGVSAFPAEVTPQMVLNFLRGGAAINVLARHVGARVIVVDIGVATDLPPHPDLVSRKLAYGTADFSQEPAMSHETARQAIAVGIACANQAIDSGVDLLATGEMGIANTTAASAVVAAITRRPASEVTGRGTGIDDSGLARKIAVIEQALHRHQPNPDDGLDVLAKVGGLEIGGLAGVILGAAARRVPVVIDGFIAGAAALIAATLAPAATAYMIAGHRSVERGHAAVFSHLDLQPLLDLNMRLGEGTGAVLAMSICQAACKILDEMATFAEAGVSEKV
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: PARA_CAUVC
Sequence: MSANPLRVLAIANQKGGVGKTTTAINLGTALAACGERVLLIDADPQGNCSTGLGIGRTQRRTTLYDVLMGEAPVVDAAVKTELPGLDVIPADADLSGVEIELGQTARRSYRLRDALEAIRANGPYTYVLIDCPPSLNVLTVNAMTAADAVFVPLQCEFFALEGLTQLMRTIERVRGSLNPRLEIQGVVLTMYDRRNSLSEQVAKDVRAHFGDKVYDAVIPRNVRVSEAPSFGKPVLLYDLKCAGSQAYLKLAREVISRERDRQAKAA
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication (By similarity).
What are the official names of this protein?
Chromosome partitioning protein ParA.
What is the protein family that this protein belongs to?
Belongs to the ParA family.
Protein: YCF12_MARPO
Sequence: MNLEVIAQLTVLALIVASGPLVIALLAARKGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12, ORF33.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NUSB_OCEIH
Sequence: MNRHKAREKAFQVLFQLDINETELEEVMETLKEKERYDVFLRSLVEGVIQHKSVIDEKISTHLEKWTIDRIASVERTILRMAILEIMYIDDIPQNVSINEAIELAHTFGDEQSGKFVNGVLSKIIA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PSBX_SYNR3
Sequence: MTPSLANFLNSLVAGALIVVVPITIALILISQTDQVDRKL
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SYK1_SALTI
Sequence: MSEQNAQGADEVVDLNNEMKARREKLAALREQGIPFPNDFRRDRTSDQLHAEFDAKEAEELEALNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKTRSKILAGIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDVLGTTQVPYGDEVFDFGKPFEKLTMHEAIKKYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVNAKAAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP196_ARATH
Sequence: MSLLRRRFVKQSVNCITFLQILAERSFSTVKIPPGRRKTTEFDKLINEAGSSGDFETVRRLLNNRIVLGSFNTSDTFKFLTNTASYSSYLEDLRRVLPQIDGGFSRKNAYDILISRLCKLGRIDDALIVIGDMSNGRLGLTPSTYHPILCSLTRKYKIEEAWRVVESMRSKSVSMDVTAYNYFLTSHCYDGELESASEVMRKIEEDGNSPDSRSYDALVLGACRAGKVEAAMAILRRMEEDGVTVLYSTHAHVITGLVEGGYYALGLEFVMAYAGKDLRLDSESFGFLAGKLVKRKRYEEAMIVVKEMVMRGLRMGDELRQFYEGNVRYDDDDEDSLVQSERECYIEQKLN
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g40240, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: S17AB_XENLA
Sequence: MSSPDGGYGSDDQNQGKCSVPIMMSGLGQCQWSEPMTSLGEGKLKSDANSRSKAEGRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALSLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRAENGFMHMTEAQESAVMGTDGRMCLENFNLGFHEQTYPQLPQASHYREPQAMAPHYDGYSLPTPESSPLDLAEADPVFFTSPAQDECQMMPYSYNSSYTHQHNSGASMLVRQMPQTEQIGEGSPVEGMMACQSSPHMYYGQMYLPGSTRHHQHPQAGQPSPPPEAQQLGRADQTQQADMMAEDRTEFEQYLSYVSKSDLGMNYHGQESVGPTADNGPISSVLSDATTAVYYCNYPSA
What is the function of this protein?
Transcription activator.  Binds to the DNA sequence 5'-AACAAT-3'.  All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function.  In addition, the sox17 proteins have distinct but overlapping roles in later gut development.  Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly.  Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.
What are the official names of this protein?
Transcription factor Sox-17-alpha-B, xSox17alpha2.
What are the subcellular locations of this protein?
Nucleus.
Protein: TX21A_PLETR
Sequence: MKHLIVAVVLLSALAICTSAEEEQVNVPFRPEERIGECAGWNDNCDKRSCCDQCHQCRCKFGSNCRCTGTKPSCGKR
What is the function of this protein?
Excitatory toxin that acts on both calcium and sodium (Nav) channels.  It preferentially blocks a subset of calcium channels that is apparently not required for neurotransmitter release, it decreases threshold for sodium channel activation and it slows sodium channel inactivation.  As it enhances synaptic transmission by prolonging presynaptic release of neurotransmitter, its effects on sodium and calcium channels may act synergistically to sustain the terminal excitability.
What are the official names of this protein?
Delta/omega-plectoxin-Pt1a, Delta/omega-PLTX-Pt1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 02 (plectoxin) family. 01 (Tx3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVB_RHOPA
Sequence: MTDPSRLVTPERRGDDLGDAALRPQNLSEFVGQQQARANLQVFIDAARKRKEALDHVLFVGPPGLGKTTLAQIVARELGVGFRATSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPSVEEVLYPAMEDFQLDLIIGEGPAARSVKIDLSKFTLVGATTRAGLLTNPLRDRFGIPIRLNFYTIEELESIVTRGARVLGTPITADGANEIARRARGTPRIAGRLLRRVRDFASAADAEAIDRAIADHALGALEVDSAGLDAMDRRYLTTIALNYGGGPVGVETMAAALSEPRDAIEDIIEPYLIQCGYLQRTPRGRLLTDHAFRHLGLAAPSRDPAQFGLFGDTGDQE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CYSJ_PECAS
Sequence: MTTPVSPTSLLPLSAEQLTRLQAATGDFSSTQLAWLSGYFWGLIQQPGNVQPGATIDAATTASAVTVPVQTITLISASQTGNARRVAEQLRDDLLAAKLPVNLVNAGDYKFKQIGQEKLLLIVASTQGEGEPAEEAVALHKFLLSKKAPELKDTAFAVFGLGDTSYEFFSKAGKDFDGRLAELGAERLLDRVDADVDYQALAAQWRRQLVDILQARVPVQGNAVAQLAAQGALDEITSSPYSKSSPLQATFAVNQKVTGRGSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVQELLELLWLKGDESVSVDGKALPLSQALKSHFELTQNTAPIVEKYAALSRNETLLSLLADKPALQQFAQRTPLVDMVRQAPVELTAEQLLGLLRPLTPRLYSIASSQAEAESEVHITVGVVRYEYEGRARAGGASSYLADRLSEDDEIRVFIEHNDNFRLPANSETPVIMIGPGTGIAPFRAFMQQRDADGAEGKNWLFFGNPHFTEDFLYQVEWQRYVKEGLLTHIDLAWSRDQAHKIYVQDKLREKGAEVWRWIQDGAHLYVCGDANRMAKDVERALLDVIVEHGGMDSEQADEFLSDLRLERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: SIR1_HUMAN
Sequence: MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
What is the function of this protein?
(Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein.  The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection.
What are the official names of this protein?
NAD-dependent protein deacetylase sirtuin-1, hSIRT1, NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
Protein: INV1_YEASX
Sequence: MLLQAFLFLLAGFAAKISASMTNETSDRPLVHFTPNKGWMNDPNGLWYDAKEGKWHLYFQYNPNDTVWGLPLFWGHATSDDLTHWQDEPVAIAPKRKDSGAYSGSMVIDYNNTSGFFNDTIDPRQRCVAIWTYNTPESEEQYISYSLDGGYTFTEYQKNPVLAANSTQFRDPKVFWYEPSKKWIMTAAKSQDYKIEIYSSDDLKSWKLESAFANEGFLGYQYECPGLIEVPSEQDPSKSHWVMFISINPGAPAGGSFNQYFVGSFNGHHFEAFDNQSRVVDFGKDYYALQTFFNTDPTYGSALGIAWASNWEYSAFVPSNPWRSSMSLVRPFSLNTEYQANPETELINLKAEPILNISSAGPWSRFATNTTLTKANSYNVDLSNSTGTLEFELVYAVNTTQTISKSVFADLSLWFKGLEDPEEYLRMGFEVSASSFFLDRGNSKVKFVKENPYFTNRMSVNNQPFKSENDLSYYKVYGLLDQNILELYFNDGDVVSTNTYFMTTGNALGSVNMTTGVDNLFYIDKFQVREVK
What are the official names of this protein?
Invertase 1, Beta-fructofuranosidase 1, Saccharase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
[Isoform Intracellular]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Secreted]: Secreted.
Protein: FACE_TAESO
Sequence: MDVGGALDLYGCSVNVYNAILIFIWVLFLWETYINLRQLKVAKRVTESPEEIKCLMNDVDFDKSRRYAIDKMNFDIVSGFYNILSLSAVLYFQLIAWAWHKSQEHMLFVCSYAPRSFGTTEGSEILFSLLFTVYVALFQFFESLPWSYYRHFVIEERYGFNKQTIGFFIKDRLKSLAVGLVIGLPIISMLVWIIKAGGHYFYIYAYGFTFVVSFIIMFIYPEFIAPIFDRYEHFPDCELRKKIEELAASIEFPLKKLYVVEGSKRSSHSNAYFYGFGKNKRIVLFDTLIKGFKMPGVEADSSANADESSDETQNRGCGDDEEILATLAHELGHWKLKHMTFNLIIAQINIFFMFFAFGQLINVDQLFVDFGFPPSTAPILIRLIVVFQFIFMPYSSVLEFLMTMLSRKFEFQADAFAVSLKSGEKLKSALLVLTKDNLSFPVYDWLYSMCNHSHPPIIERLAAIDAKMGKEK
What is the function of this protein?
Zinc-dependent metalloproteinase (PubMed:16750535).  Proteolytically removes the C-terminal three residues of farnesylated proteins (By similarity).
What are the official names of this protein?
CAAX prenyl protease 1 homolog, Zinc metalloproteinase Ste24 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: P52K_MOUSE
Sequence: MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIEETSEQEQETNTNAQNPSAEAVNQQDANVLPLTLEEKENKEYLKSLFEILVLMGKQNIPLDGHEADEVPEGLFAPDNFQALLECRINSGEEVLRKRFEATAVNTLFCSKTQQRHMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFFHRSPQLLLELDSVISVLFQNSEERAKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGIINSDTNVRWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQQGNLESQLTSESYYKDTLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTNKSELPTINSETIENT
What is the function of this protein?
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR).  May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
What are the official names of this protein?
52 kDa repressor of the inhibitor of the protein kinase, p52rIPK, 58 kDa interferon-induced protein kinase-interacting protein, p58IPK-interacting protein, THAP domain-containing protein 0, THAP domain-containing protein 12.