PharMolix/UniProtQA huggingface dataset:
Protein: WDR12_XENTR
Sequence: MAQIQARFFTEEEKYKVDDVPFSIPATSEIVDLSNLINKLLETKNGDHKPVEFDFLVKSQFLRMPLIKHMEAEGISTEVVVEIEYVEKITAPQPEECMMHDDWVSSIAGTEEWILTGSYDKTCRIWSLEGKTIMTITGHTEAVKDVTWVKKDSLSCLLLSASIDQTIQLWEWNTERNKIKALHCCRGHAGSVDSIAVDASRTKFCSGSWDKMLKIWSAVPSEEEDEYEETSDRPRKKQKTEKMGLTRIPIVTLSGHSEAVSSVLWSDVDEICSASWDHNIKIWDVETGTVKSTLAGNKVFNCISYSPLSQRLASGSTDRHIRLWDPRSKDGSLVLCSLTSHTGWVTSVKWSPSHEQQLVSGSLDKLVKLWDTRSCKAPLYDLAAHSDKVLSVDWTDAGLILSGGSDNKLYSYRYTASLSDVGA
What is the function of this protein?
Component of the PeBoW complex, which is required for maturation of 28S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein wdr12, WD repeat-containing protein 12.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: HISZ_BURPS
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLTGLKKIRLDLCHAGVLAALFARDAAAAERGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDDARRLLPALPEIARALDDLAHLAAQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVIEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PBLST_EUGGR
Sequence: MYILVWKKGQQIKTFHTLDEAAQFKAASNIDEAQMFSVTVASAISASGGSTEATNLRRLMYLSKSTNPEECNPQFLAEMARVAFIRNREIRVSGFLMYSSPFFIQVIVETDEDLDFLFAKISADPRHEMCIVLANGPGTGRMYGDWHMKDSHLDSITTHTAMKTILYQIARSFSSMWIYLQKSAANMLMLGKDPAAQPPERRSVVVTFIYLVEFCSIFSHPNLTEKTADVLSTFVYVCVKNVEGSGGNIAKFIPAICMTYWPIIRTKEALTAIQQISEDLAQLRSQQAQGSAVSLRYSQAGVHYGRGMQCNAGSRKSDFTLLGDCINTTSRIATLAKKLKTPLLFGFEVRCLLGDEKREEIEGAGIHQVKGRDKPVVVYQFPGPDLDVAMVRQKIEQFTPGRFRCQMPVVEYEALPISQRPPIFDDTPKSNPRPRTPGYGGRQRSDSLVDRLIRIANLSGFSESATGDTTLTTLTYISQATRPMSRLDLSAIMPTATRRNAQQSNIGTVLHENGLFVQTLEGPKDAVVNLYLRIRQDPRHTDVTTVHMAPLQERVYTSEWTLTLATEEMLATFPPVQDVLSQLAKSYTSLETYVPSTVVRYLTAGNNPRNLMPVSCGVVMLATDISSFTSLTEISSFTEVWMICNTFIDACTSAICQEGGEVIKLIGDCVTPYFPGNNADLAVAAAQELFIFCRQLREAFVDVLDVRGCVSCAVGMDYGQVVMAQCGLLRLSDYVAAGAVSAGVVEVEAITREVGYQFVVTVPDADRVQPQFRDYGIEPTPQAIGGLPCYGIVREVFDLPVESIKRGIKAMHAARSGEQPLTEPEQAKPDFRVSPGRDRHGVSGRRSNSSQGKGSIQVG
What are the official names of this protein?
Photoactivated adenylate cyclase subunit beta-like protein ST-.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum.
Protein: ZAPB_HAEI8
Sequence: MSLEILDQLEEKIKQAVETIQLLQLEVEELKEKNAESQRNIENLQTENEQLKNEHRNWQEHIRSLLGKFDNV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: METR_SALTI
Sequence: MIEIKHLKTLQALRNSGSLAAAAAVLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEVLLQLANQVLPQISRALQACNEPQQTRLRIAIECHSCIQWLTPALENFRASWPQVEMDFTSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDFEVRLVLAPDHPLASKTQITPEDLASETLLIYPVQRSRLDVWRHFLQPAGISPLLKSVDNTLLLIQMVAARMGIAALPHWVVESVERQGLVVTKTLGDGLWSRLYAAVRDGDQRQAVTEAFIRSTRDHACDHLPFVRSAERPIFDAPTAKPGSQPRL
What is the function of this protein?
Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes.  It is also a negative regulator of its own expression (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator MetR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_ACIB5
Sequence: MKQQAKSRKPQQPEYIFQVETLSHEGRGIAHYGSHPDHPADKHGKKVFIRYALPGETVKAQITHEAKRLEEAEMVELLAEPSANRVEAVCPHYGICGGCSMQHIHPDEQIHLKQNVLQSHLQHFAGIQPEQWLEPIRSLQSDYRRRARIGVRYLPKQDRLILGFREHHSNRLTSIHTCSVLDKKLSDNLPELRNLLQSLKGKAHIGHVELAKGDHEISLLVRHIEKLNNADVNQLRQFALHKGWQLYLQPKDQSLRRIDEEQGAMRLHYALNAFDVNFAFSPLDFTQVNATVNEQMVQLACELLQLQQGERVLDLFCGLGNFSLPLARCVGAKGQVVGVEASEEMVQRATDNAKRNNLVQASFFSQDLTKDFSHHSWANQGFDALLIDPPRAGAYEIMQYVPNFGAKRIVYVSCNPATLARDAGVLVQHGYQLKKAAVMDMFTHTEHVESIALFEKIQEIND
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: MCE1_YEAST
Sequence: MVLAMESRVAPEIPGLIQPGNVTQDLKMMVCKLLNSPKPTKTFPGSQPVSFQHSDVEEKLLAHDYYVCEKTDGLRVLMFIVINPVTGEQGCFMIDRENNYYLVNGFRFPRLPQKKKEELLETLQDGTLLDGELVIQTNPMTKLQELRYLMFDCLAINGRCLTQSPTSSRLAHLGKEFFKPYFDLRAAYPNRCTTFPFKISMKHMDFSYQLVKVAKSLDKLPHLSDGLIFTPVKAPYTAGGKDSLLLKWKPEQENTVDFKLILDIPMVEDPSLPKDDRNRWYYNYDVKPVFSLYVWQGGADVNSRLKHFDQPFDRKEFEILERTYRKFAELSVSDEEWQNLKNLEQPLNGRIVECAKNQETGAWEMLRFRDDKLNGNHTSVVQKVLESINDSVSLEDLEEIVGDIKRCWDERRANMAGGSGRPLPSQSQNATLSTSKPVHSQPPSNDKEPKYVDEDDWSD
What is the function of this protein?
Second step of mRNA capping.  Transfer of the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
What are the official names of this protein?
mRNA-capping enzyme subunit alpha, GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GTase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTP1_CAEEL
Sequence: MRLGSNSYDVQRTEAIGQTPVKTPPPNQIRCTVTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFIAVDNSSAQQKKWLDPSKNLRKQMICPPYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQNFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGIKMNEYAWVRIRKLSFKKKQFQVLVANEDGVSETIMIFNIMSAKICKLLWKCCIEQHTFFRLKTPPKTPQRKVFNFGSKFRYSGRTEYQTLEENEHRKSAGHRNFHRSLSKSSFLRSTFSGNTQSIDSSRYTNTTTTDSPELPSSGQLLARRLLSAARHDTDSSDALGYASDGAVVCAPLTTPLSPRRTRDYATDSESSAPSLRQQRLSKEAIYYGTQESCDEKSWTPSMACTSTSPGIHASTASVRPVSSGSTPNGASRKSANSGYSGYGYATQTQQPTSTTNASYSPYLNGTISRSSGAAVAKAAARGLPPTNQQAYNTSSPRNSVASYSSFASAGIGGSPPRSKRSPQSNKSSSPVGEDQVVTIKMRPDRHGRFGFNVKGGADQNYPVIVSRVAPGSSADKCQPRLNEGDQVLFIDGRDVSTMSHDHVVQFIRSARSGLNGGELHLTIRPNVYRLGEEVDEPDSTMVPEPARVADSVPNSDKLSKSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGTIKPLAEYSKR
What are the official names of this protein?
Tyrosine-protein phosphatase 1, Protein-tyrosine phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ACP_ACIF5
Sequence: MDNVADRVKKVVVEQLGVNEDEVTNEASFVDDLGADSLDTVELVMALEEEFDCEIPDEEAEKIATVQQAIDYVSAHIPAKDA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_RICPU
Sequence: MNATILVKIITPLSIALEKQAKMVTMSGEEGMFGVLPSHVPMIVSLKAGLVQVYIDDMHKSENTYLISGGVTEVTANYINIATDTAINVTNLSEAEIATKLLDLQKTLSDQH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UVRA_STRR6
Sequence: MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKKGQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTLREGALAPWNPISSNYYPNMLEQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVEFFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_PHOPR
Sequence: MRTQYCGHLNKSLEGQTVELCGWVNRRRDLGGLIFIDMRDREGIVQVVVDPDMKDVFELANQLRNEFCIRLIGEVRVRPESQVNKKMATGEVEILATGLEIINRSDVLPLDFNQNNSEEQRLKFRYLDLRRPEMSDRIKLRAKASSFVRRFLDENAFLDIETPVLTKATPEGARDYLVPSRVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFMSAEQVREITEKMITEMWKELLNVDLGTFPIMQFEEALRRFGSDKPDLRNPLELVDVADILKDVDFKVFSGPANDEKGRVAVIRVPGGASLSRKQIDEYTKFVGIYGAKGLAWMKVNDREAGFAGVQSPVAKFLNEDVVANLLDRTQAETGDIILFGADSKRVVTEALGALRLKLGEDLELTDKSIWKPLWVIDFPMFEEDGEGNLHAMHHPFTSPLGITAEELAVNPAAANSNAYDMVINGYEVGGGSVRIHNADMQSAVFNILGIEEGEQQSKFGFLLEALKYGTPPHAGLAFGLDRLVMLLCGTDNIRDVIAFPKTTAASCLLTNAPSLANPDSLKELSIAVAIAKKETAKEESAE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANA_SALPB
Sequence: MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECNKVIDLLIKTGVFRGLKTVLHYMDVLSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TKTC_METJA
Sequence: MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAEQNMIGMAAGLATTGKIVFASSFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDGASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYKGPVYVRMPRRDTEIIYENEEEATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEIIKKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGLDGESIAKRIMEEMKKE
What are the official names of this protein?
Putative transketolase C-terminal section, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: CH10_AZOVD
Sequence: MKLRPLHDRVVIRRSEEETKTAGGIVLPGSAAEKPNRGEVVAVGTGRVLDNGEVRPLAVKVGDKVVFGPYSGSNTIKVDGEDLLVMGENEIFAVVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XGPT1_HAEI8
Sequence: MSEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCIASYHDHNNQGELQVLHAAQVPNGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPAGAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase 1, XGPRT 1, Xanthine phosphoribosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATXE2_ASTEC
Sequence: MRSSKIRCPGAIRVGTLVTAFGCLPHVAFAAAREAPPVTPEVLVRLADIGTMSASETTPLLSLSPDGRYVAFQVRQADPVTNLNVFRMVVKATDGATDAIDVDVGGEYLFWTIPSWGYARNAPSGANLTIQPRWSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSGRPGFVEAEAEIEREGRRGWVYDERFHPLTGARPRVLEPISIVYQVLDLKTGTRRAATPTEVARLREKPDPLRAMVGRTTFSVSRTDPQNINAPTTLVARRGEGEPVRCDEEACQNITRMWGDETANVLYFLRREGWASNEMALYRMPADALKPVRIWHATGLLQGCERQAKRLICAQESALQPRRLVTLNLTSGQMSPLYDPNPDLSRYRLPKVERLTLRNRNGIEVFSDLVLPPDYQLGTRLPLVIVQYSSRGFLRGGTGDENPILPLATAGFAVLSFHSPRSEASYQRFTSPIAQSKAEYSNWRNRWNILHTLEDLIDDLDRRGVIDPARVGLTGLSDGATTVHFGLINSHRFAAAVTSSCCTDSFTASVMNGPRISGALKAYGIETDQADDGPFWAATSFVVNASRLDTPLLIQSADEEYLGALPGFTALQQARKPVELIIYPNEHHVKWQPAHRLAVYNRTIDWFRFWLMDQSDPAPDKAAQYDRWRALRALRQKSPSPTPAP
What is the function of this protein?
Lasso peptide isopeptidase that specifically hydrolyzes Astexin-2 and Astexin-3, converting them to linear peptides (PubMed:23862624).  Has only a few specific contacts with subrates, because it recognizes Astexin knotted structure (principally the loop structure) (PubMed:26534965, PubMed:27998080).  Its binding to lasso peptides opens them to expose the isopeptide bonds for hydrolysis (PubMed:27998080).
What are the official names of this protein?
Lasso peptide isopeptidase AtxE2, Isopeptide hydrolase AtxE2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPP2_RAT
Sequence: MPVAATNSESAMQQVLDNLGSLPNATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNNLELVQEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRSASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGVSTKQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY
What is the function of this protein?
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895).  In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity).  Seems to negatively regulate SRC function in epithelial cells (By similarity).
What are the official names of this protein?
MAGUK p55 subfamily member 2, Protein MPP2.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell projection, dendrite. Postsynaptic density. Cytoplasm, cytoskeleton. Membrane. Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.
Protein: GAG_HV196
Sequence: MGARASVLSGGKLDAWEKIRLRPGGKKKYKLKHLVWASRELERFALNPGLLETTEGCRQIITQIQPSIQTGSEEIKSLYNTIAVLYFVHQKIEVKDTKEALDKLEEEQNKSQRKTQQEAADKGVSQNYPIVQNLQGQMVHQALSPRTLNAWVKVIEEKAFSPEVIPMFTALSEGATPQDLNTMLNTVGGHQAAMQMLKDTINDEAAEWDRLHPVHAGPIPPGQMREPRGSDIAGTTSTLQEQIAWMTSNPPVPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFFKTLRAEQATQEVKNWMTDTLLVQNANPDCKTILKALGPGASLEEMMTACQGVGGPSHKARILAEAMSQVTNPVVMMQKGNFKGHRKIVKCFNCGKEGHIARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSHKGRPGNFLQSRPEPTAPPAESFGFGEEITPSPRQETKDKEQSPPLTSLKSLFGNDPLSQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: GLSA_AERS4
Sequence: MVLSSELLASILAEVRPLLGQGKVADYIPALAQVPADRLGMAVCTVEGELFTAGDAFEPFSIQSISKALSLTLALTLYQEEEIWARVGKEPSGQPFNSLVQLEFEQGIPRNPFINAGALVVSDLLETRLTAPRQRTLELVRRLSGNPAIMADQVVARSEYQHSARNAAIAYLMKAYGNFENEVDKVLQSYFNACAIRMSCVDLARAFIYLANRGVPLGAGEPLLPARTTKQVNALLATCGLYDEAGDFAYRVGMPGKSGVGGGIMALIPGELCVCVWSPELNKAGNSLAGTAALELLAERLGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: CYB_ARTSF
Sequence: MLGNKMLSLPEQQPTLKIINSALVDLPVPANISIWWNFGSLLGLCLLIQIVIGLFLAMHYTAWVELAFSSVANICRDVNYGWLLRTVHANGASFFFICIYFHIGRGMYYGSFHYFETWMTGIALLFLVMAAAFLGYVLPWGQMSFWGATVITNLVSAVPYIGNDVVQWLWGGFAVDNPTLTRFFTFHFLIPFLVAGLTMIHLLFLHQSGSNNPLGINANLDKLPFHPYFTIKDTVGFMVLIFFLVTLSLTSPYLLGDPDNFIPANPLVTPAHIQPEWYFLFAYAILRSIPNKLGGVIALVSSILILVSLPFTFKPKFRGLEFYSVAQPLFWSWVSVFLLLTWIGARPVEDPYNFLGQILTCAYFSYFVFTPIVINLNDKIV
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPD_SCHPO
Sequence: MFRLSNYMLRKSQFPQGLVRAPFGIRGYAQAVQKNEKLVLSMALPYQTIYEKVPVTQVDIPAEDGEMGILKDHVPMIQCLKPGVISVTDESSNKSKYFISGGFAVQQPSNELSITVPEAYKLEDFSSSVANQLLEKHKAEMNSSDEGVAAEAAVRVSVLESLVRALK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element.  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).
What are the official names of this protein?
ATP synthase subunit delta, mitochondrial, F-ATPase delta subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
Protein: LEUD_PYRNV
Sequence: MKVRGKAIVYGDKIDTDVIIPAKYLVYTDPAVLGQHAMEPLDPEFPKKAKGAVLVAGRAFGMGSSREQAAIALKGAGVLAVVAESFARIFFRNAINVGLPVLQVPDVTKRVREGDELEVDIEGGYLLNLTTGERLEGKPLRGLPLAILKAGGLVNFLKTAGR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: AROC_PROM3
Sequence: MGSSFGDLFRISTFGESHGGGVGVIVEGCPPRLELDLQKIQAELDRRKPGQSKISTPRKEEDQVEILSGLLNNTTLGTPIAMVVRNKDHKPGDYKEMNVAFRPSHADATYQAKYGIQARSGGGRASARETIARVAAGAIAKQLLTKAHNTEVLAWVKRIHTLEAEINAQDVSIDDVEANIVRCPNQVMAAQMVERIEAISREGDSCGGVIECVVRNAPMGLGMPVFDKLEADLAKAVMSLPASKGFEIGSGFGGTLLKGSEHNDAFLPSNDGRLRTATNNSGGIQGGITNGESIVIRVAFKPTATIRKDQQTIDADGNTTTLSAKGRHDPCVLPRAVPIVEAMVSLVLADHLLRQQGQCSLW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y1786_STAAW
Sequence: MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
What are the official names of this protein?
UPF0342 protein MW1786.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.