PharMolix/UniProtQA huggingface dataset:
Protein: FKB1B_BOVIN
Sequence: MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE
What is the function of this protein?
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin.  PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FKBP-12.6, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Sarcoplasmic reticulum.
Protein: MAMS_MAGGM
Sequence: MDFRPDQVVARIRGAVEGALTAQSVLGIGGALVLILVVIALLPDRFTRGEGKTATAVSSGAAQALPAALPGLSPFTPAKPLQFSGRVTQVASIGNDVGWGQVHVWIDNGTGALQEISVAPQSYLNQIGCPSFDGARISGIGFLFDAGRPNAELYAKSVLVGGRTCKLRDDEGLALWMTVQ
What is the function of this protein?
May play a role in magnetite crystal growth and size.
What are the official names of this protein?
Magnetosome protein MamS.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamS family.
What are the subcellular locations of this protein?
Magnetosome membrane; Single-pass membrane protein.
Protein: DDL_RHOE4
Sequence: MNSSRTRVAVIFGGRSNEHSVSCVSAGSVLSNLDPDRYDVVPIGITVDGSWVLGSSDPSSLAISGRALPSVDKDGTSVVLSADPTREGEVISFDGSDAGAVLASVDVVFPVLHGAYGEDGTIQGLLELAGVPYVGPGVLASAAGMDKEFTKKLLAAEGLPVGVQVVLRPGIATLTEEQKAELGLPVFVKPARGGSSIGITRVSNWDGLDGAIAHARLHDPKVIVEGAIIGREVECGVLEFPNGDVKASVVAEIRMPDADTDSDAFYDFDTKYLDDVCEFDIPAKLDESVSDQIRELAVRAFKALDCQGLSRVDFFVTADGPVINEINTMPGFTSISMYPKMWNATGIDYRTLISTLVDTAIARGTGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_ACET2
Sequence: MECLMAVILAAGEGKRMKSKKAKVVHEIQGIPLVEWVYRSVKNAGIDEVVLVVGHKAEEVKEKMGDKVLYAFQEKQLGTGHALMQAQEYLKDKDGYVVVLYGDTPLITSKTISDTINYHREQANSATIITAVLNNPDGYGRIVRSGDGSVRKIVEHKDASLEERNIKEINSGIYCFNIRDLTEALKELDNNNSQGEYYLTDTIEILINKGKKVGAIKVEDSSEILGINDRVQLAEAGRIIRSRILKRHMKNGVTIIDPDSTYIDEDVEIGIDTVVYPSTIIEGKTKIGEDCIIGPGSRLVNAQISDRVEVKNSVVLESSIDNDTKVGPFAYVRPGSVIGKNVKIGDFVEIKKSVIGDKTKISHLTYVGDAEVGKNVNLGCGVVVVNYDGKKKNKTIIGDNAFVGCNVNLISPVEVKDNAYVAAGSTITEEVPEYSLAIARSRQTIKEDWVIKKGMLRQEKE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_VIBPA
Sequence: MATVTAALVKELRERTGAGMMECKKALVEANADIELAIENMRKSGAAKAAKKAGNVAAEGAIIIKEENGSAVLLEVNCQTDFVAKDGNFTAFAQEVAAAALASKATVEELQAQFEEARVALVAKIGENINIRRVQYVEGTAIASYRHGEKIGVVVAGEGDAETLKHVAMHVAASKPEYVNPEDVPADVVAKEKEVQVEIAMNEGKPAEIAEKMVVGRMKKFTGEISLTGQAFIMEPKKTVGEMLKEKGASVATFVRLEVGEGIEKAEGLSFAEEVALAQKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBK_MARPO
Sequence: MFNIYLENAFYLNGITFAKLPEAYSIFDPIVDVMPIIPLFFFLLAFVWQASVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: KLF1_DANRE
Sequence: MAVTQAVLPSFSNFCTNSENMKFEKGFLDLDSKDLHQSPASYKPSQFLTDEHQDDSEGCWDMEFLLSDWASMSPERSNSQNYTPQRPTLQDQLHSPDLYQELNAPKPNRHQVCVASSLAELLPPEATLSSSLPPDLQFNCGFLDQQAAKSYSQAENPQQFSAFPVTSNVNRDSSMGKMGKSWDFGHYYQPAPLISFPDSKFVQTQGITMETVVFPPHHHYNFIPSYSHPRLYQQQANYVHRPPPQSHFPSTQSMVPDSTVPPAGLESKRIRRGLVKRKATVHSCEYPGCQKTYTKSSHLKAHLRTHTGEKPYHCTWDGCGWKFARSDELTRHFRKHTGQKPYECLLCHRAFSRSDHLALHMKRHV
What is the function of this protein?
Transcription regulator (PubMed:18941117, PubMed:33833125).  Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1. 1 and microRNA mir-144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144 (PubMed:33833125, PubMed:18941117).  May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes (PubMed:33833125).  Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts (PubMed:33833125).
What are the official names of this protein?
Kruppel-like factor 1, Erythroid krueppel-like transcription factor, Kruppel-like factor d.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Colocalizes with the cytosolic muscle marker troponin C.
Protein: DEGP1_ARATH
Sequence: MATTTSCSLLLSSTLFLHSPPSSHLSFFNLSSSRSSPISLYPIRSKRYFRILSKLSLNDNNRDDDDDTLHFTPFSAVKPFFLLCTSVALSFSLFAASPAVESASAFVVSTPKKLQTDELATVRLFQENTPSVVYITNLAVRQDAFTLDVLEVPQGSGSGFVWDKQGHIVTNYHVIRGASDLRVTLADQTTFDAKVVGFDQDKDVAVLRIDAPKNKLRPIPVGVSADLLVGQKVFAIGNPFGLDHTLTTGVISGLRREISSAATGRPIQDVIQTDAAINPGNSGGPLLDSSGTLIGINTAIYSPSGASSGVGFSIPVDTVGGIVDQLVRFGKVTRPILGIKFAPDQSVEQLGVSGVLVLDAPPSGPAGKAGLQSTKRDGYGRLVLGDIITSVNGTKVSNGSDLYRILDQCKVGDEVTVEVLRGDHKEKISVTLEPKPDES
What is the function of this protein?
Serine protease that is required at high temperature.  May be involved in the degradation of damaged proteins.  In vivo, can degrade beta-casein.
What are the official names of this protein?
Protease Do-like 1, chloroplastic, Protein DEGRADATION OF PERIPLASMIC PROTEINS 1, DEGP PROTEASE 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
Protein: NARG_HALMT
Sequence: MSRNDASQLDDGETTAESPPDDQANDAPEVGDPPGDPVDADSGVSRRTFLEGIGVASLLGIGTSAASDDSLFQMGGLKPVDDPIGNYPYRDWEDLYREKWDWDSVSRSTHSVNCTGSCSWNVYVKNGQVWREEQSGDYPRFDESLPDPNPRGCQKGACYTDYVNADQRIKHPLKRVGERGEGKWKRISWDEALTEIAEHVVDEVEAGRYDAISGFTPIPAMSPVSFASGSRLVNLLGGVSHSFYDWYSDLPPGQPITWGTQTDNAESADWYNADYIIAWGSNINVTRIPDAKYFLESGYNGTKRVGVFTDYSQTAIHTDEWLSPDSGTDTALALGMAQTIVDEGLYDEAHLKEQTDMPLLVRQDTGKFLRASDVPSVNTDADRPEWMLLMLDSNGRIREAPGSLGERDGQKDYSKSIELDFDPQLDGETTVQTQSGRVQVRTVWAELRDELANWDPEMVHEETTVGKETYQRIAREFAEADKAKIIQGKGVNDWYHNDLGNRALQLLVTLTGNLGEQGTGLDHYVGQEKIWTFHGWKTLSFPTGKVRGVPTTLWTYYHAGILDNTDPDTAAKIRESIDKGWMPVYPEERDNGSRPDPTTMFVWRGNYFNQAKGNVAVEEQLWPKLDLVVDINFRMDSTAMYSDIVLPTASHYEKHDLSMTDMHTYVHPFTPAVEPLGESKTDWQIFRELAQKIQEVATERGVEPISDRKFDREIDLQSVYDDYVRDWETGEEGALAEDRAACEYILEHSEESNPADSDEQITFADTVEQPQRLLEAGDHWTSDIEDGEAYAPWKDFVQDKNPWPTVTGRQQYYIDHDWFLELGEELPTHKEGPENTGGDYPMEYNTPHGRWAIHSTWRDSEKLLRLQRGEPLLYLHPEDAEERGIEDGDSVEVFNDLAEVELQAKIYPSSQRGTARMYFAWERFQFDSDSNFNSLVPMYMKPTQLVQYPEDSGEHLHFFPNYWGPTGVNSDVRVDVRKAGGGDE
What is the function of this protein?
The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions.  The alpha chain is the actual site of nitrate reduction.
What are the official names of this protein?
Respiratory nitrate reductase subunit alpha, Nitrate reductase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side.
Protein: RPOB_MYCUA
Sequence: MLEGRILADFRQTDASLHQGRPQSSSNSSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSQRWRESAAQRGDATPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDEVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGGFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKLLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWSNEQIHERFGFSEIMMGTLEKDNTAGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLNAGQPITSSTLTEEDVVATIEYLVRLHEGQTAMTAPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIHYLTADEEDRHVVAQANSPIDAQGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVADKAGVIEEVSADYITVMADDGTRHTYRMRKFARSNHGTCANQSPIVDAGERVEAGQVIADGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPAEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKSGWNIDVANGVPEWAGKLPENLLSAQPDSIVSTPVFDGAQEAELQGLLSATLPNRDGEVLVDGDGKAKLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: POC5_HUMAN
Sequence: MSSDEEKYSLPVVQNDSSRGSSVSSNLQEEYEELLHYAIVTPNIEPCASQSSHPKGELVPDVRISTIHDILHSQGNNSEVRETAIEVGKGCDFHISSHSKTDESSPVLSPRKPSHPVMDFFSSHLLADSSSPATNSSHTDAHEILVSDFLVSDENLQKMENVLDLWSSGLKTNIISELSKWRLNFIDWHRMEMRKEKEKHAAHLKQLCNQINELKELQKTFEISIGRKDEVISSLSHAIGKQKEKIELMRTFFHWRIGHVRARQDVYEGKLADQYYQRTLLKKVWKVWRSVVQKQWKDVVERACQARAEEVCIQISNDYEAKVAMLSGALENAKAEIQRMQHEKEHFEDSMKKAFMRGVCALNLEAMTIFQNRNDAGIDSTNNKKEEYGPGVQGKEHSAHLDPSAPPMPLPVTSPLLPSPPAAVGGASATAVPSAASMTSTRAASASSVHVPVSALGAGSAATAASEEMYVPRVVTSAQQKAGRTITARITGRCDFASKNRISSSLAIMGVSPPMSSVVVEKHHPVTVQTIPQATAAKYPRTIHPESSTSASRSLGTRSAHTQSLTSVHSIKVVD
What is the function of this protein?
Essential for the assembly of the distal half of centrioles, required for centriole elongation.
What are the official names of this protein?
Centrosomal protein POC5, Protein of centriole 5, hPOC5.
What is the protein family that this protein belongs to?
Belongs to the POC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles.
Protein: PABP_PICST
Sequence: MSAADANQLQESLEKLNLDSAPAAAEEEAVAAESAPAGEEGADSANVAESTASLYVGELNTSVNEATLFEIFSPIGQVSSIRVCRDAVSKKSLGYAYVNYHKMEDGEKAIEELNYSPIEGRPCRIMWSQRDPSARRSGDGNIFIKNLHPAIDNKALHDTFSTFGKILSCKVATDDMGQSKCFGFVHYETAEAAEAAIENVNGMLLNDREVFVGKHISKKDRESKFEEIKANFTNIYVKNIDLEYSEEDLKKLFTPYGAITSIYLEKDAEGKSKGFGFVNYEGHEAAVKAVEELNDKEINGQKIYVGRAQKKRERMEELKKQYENTRLEKLSKYQGVNLFIKNLDDTIDSEKLEEEFKPFGTITSARVMVDETGKSKGFGFVCFSSPEEATKAITEMNQRMFFGKPLYVALAQRKDVRRSQLEQQIQARNQMRMQNAAATGGIPGQFIPPMFYGQQGFFPPNGRGNAPFPGPNPQMIMRRGQPFGGPEQWPRPGPNGQPVPVYGIPPQAYSDFNGQNIRQQRGYYPNRNQNKGRQQRDLAAIIASAPPDQQKRILGEELYPKIVATGKAQEPEAAGKITGMMLDLDNQEILALLEDDELFTNHFEDALTAFEEYKNSEAAAPVAPAAPAEPQA
What is the function of this protein?
Binds the poly(A) tail of mRNA.  Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.  In the nucleus, involved in both mRNA cleavage and polyadenylation.  Is also required for efficient mRNA export to the cytoplasm.  Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation.  In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein, cytoplasmic and nuclear, PABP, Poly(A)-binding protein, Polyadenylate tail-binding protein.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RECO_XANOP
Sequence: MLIEHERGFVLHVRAWRETSLLVEVLTEQHGRVGLLARGVHGPRKQALRAALQPLQLIQFSAVQRGELAQLRQAEALDTAPRLVGDTMLAGFYISELLLRLAPRNDPVPELYACYTQARTHLAADLPLAWGLRRFERDVLEGLGFAFDLQHDSDGQPIDPAARYRLDPEEGALRVLSERLAQDRRETVTGAALLALGEDVMPAAEDMPGLRRSMRSVLLHHLGGRGLKSWEMLEDLARRR
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: LHWL3_ARATH
Sequence: MGSTSQEILKSFCFNTDWDYAVFWQLNHRGSRMVLTLEDAYYDHHGTNMHGAHDPLGLAVAKMSYHVYSLGEGIVGQVAVSGEHQWVFPENYNNCNSAFEFHNVWESQISAGIKTILVVAVGPCGVVQLGSLCKVNEDVNFVNHIRHLFLALRDPLADHAANLRQCNMNNSLCLPKMPSEGLHAEAFPDCSGEVDKAMDVEESNILTQYKTRRSDSMPYNTPSSCLVMEKAAQVVGGREVVQGSTCGSYSGVTFGFPVDLVGAKHENQVGTNIIRDAPHVGMTSGCKDSRDLDPNLHLYMKNHVLNDTSTSALAIEAERLITSQSYPRLDSTFQATSRTDKESSYHNEVFQLSENQGNKYIKETERMLGRNCESSQFDALISSGYTFAGSELLEALGSAFKQTNTGQEELLKSEHGSTMRPTDDMSHSQLTFDPGPENLLDAVVANVCQRDGNARDDMMSSRSVQSLLTNMELAEPSGQKKHNIVNPINSAMNQPPMAEVDTQQNSSDICGAFSSIGFSSTYPSSSSDQFQTSLDIPKKNKKRAKPGESSRPRPRDRQLIQDRIKELRELVPNGSKCSIDSLLERTIKHMLFLQNVTKHAEKLSKSANEKMQQKETGMQGSSCAVEVGGHLQVSSIIVENLNKQGMVLIEMLCEECGHFLEIANVIRSLDLVILRGFTETQGEKTWICFVTESQNSKVMQRMDILWSLVQIFQPKANEKG
What is the function of this protein?
Transcription factor that may regulate root development.
What are the official names of this protein?
Transcription factor bHLH155, BHLH transcription factor gamma, bHLH gamma, Basic helix-loop-helix protein 155, AtbHLH155, bHLH 155, LONESOME HIGHWAY-like protein 3, bHLH transcription factor bHLH155.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family. LHW subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AKL2A_DANRE
Sequence: MRALRAPVLVMGLVLLICTAAQSDASANKVEKTLRRIMEIMRQVENSADDESAQKTESAPEPKDTHHLKTASGETILEIFPRDLSRKEKFITILTGRRLSNPLRHQSCVFETSDLVVFHPSGPLYFGPKCKKDVYRLYHNTRDCTIPAHYKRCARLLTRLAGTRKCQEG
What is the function of this protein?
Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532).  Required for neural crest cell differentiation and iridophore development during embryonic iridophore development and adult stripe development by acting as a receptor for LTK (PubMed:29078341, PubMed:29317532).
What are the official names of this protein?
ALK and LTK ligand 2a, Augmentor alpha-1, AUG-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ALKAL family.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CDC6_METST
Sequence: MNNIFKTINNKDSIFLTKKYLDHRFIPETLPHRDEKIKSIAQYWVESLDKITPPDITIYGKTGTGKTAVTLYAKKQLEEVAAEQNLNIRVEYIRCTDYNTEYQILARLCQQLGKPVPYRGWTKAEVVNAFRNLFKKNILGEDLILIVILDEVDVILKNDGDNILYTLTRTDNVAITSISNYIDFKQFIKPKVKSSLRDREIVFPPYNAQQLIDILKERSKVSFSEGAISEGVIALCSALAAKEEGDARYALDLLKTSGEIADEKESSVIEESFVKEAKDRIEHSKIIDVVVTLPIQQQKVLESITYLTKKREEITSGRLYEVYQDLAKNDKVSYRRIFDFINELEMLGLISTNTISRGRGKGRTNIITLQCDIELIDKALIYKD
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: DAPE_LEPCP
Sequence: MHLPTLSLVEELIARRSVTPDDAGCQALIAARLAALGFEIHALPHGPADARVDNLWAIRRGQGDGPTLVLAGHTDVVPTGPLERWHSDPFVPSHRAGLLYGRGAADMKTSLAAMVVAVEEFVAAHPVHRGSVAFLLTSDEEGPAVDGTVKVCEWLAARGERLDACIVGEPTSVRQLGDMIKNGRRGSLSGRLTVVGQQGHIAYPHLARNPIHLAAPALAELAQQRWDDGNEHFPPTSWQMSNIHAGTGATNVIPGELVVDFNFRFSTESTPESLQQQVHALLDRHGLEHRIAWTLGGRPFLTRPGSLTDALSQAITAVTGLRTELSTTGGTSDGRFIAQICPQVVEFGPVNATIHQVDEHCEVAALGPLKDIYRRTLEAMLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: SYQ_YERE8
Sequence: MSEAEARPSNFIRQIIDEDLASGKHTSVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGQCNLRFDDTNPVKEDVEFVESIKRDVEWLGFTWSGDVRYSSDYFDQLYQYAVELINKGLAYVDELTPEQMREYRGTLTAPGKNSPYRDRSVEENLALFEKMRAGGFAEGTACLRAKIDMASPFMVMRDPVLYRIKFAEHHQSGNKWCIYPMYDFTHCISDAIEGITHSLCTLEFQDNRRLYDWVLDNISIECHPRQYEFSRLNLEYSIMSKRKLNLLVTEKVVEGWDDPRMPTISGLRRRGYTAASIREFCRRIGVTKQDNNVEMMALESCIRDDLNENAPRAMAVLDPIKVVIENRAAGEEWLTMPNHPNNPDMGTRQVPFDSEIYIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGHVTTLYCSYDAETLNKDPADGRKVKGVIHWVSVKHALPAEIRLYDRLFSVPNPAAAEDFLSTINPESLIIRQGFVEPSLADAVPEKTYQFEREGYFCADSHYSRPDALVFNRTVGLRDTWAAKVTN
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBX2A_MOUSE
Sequence: MKEVDNLDSIKEEWACETGPPDSQPLNDNQQKDCEYFVDSLFEEAGKAGAKCLSPTEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELWGIFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPRIVSKAKSVEVDNKSTLSAVSLNNLEPITRIQIWLANGERTVQRFNVSHRVSHIKDFIEKYQGSQRSPPFALATALPFLRFLDETLTLEEADLKNAVIIQRLQKTAEPFRKL
What are the official names of this protein?
UBX domain-containing protein 2A, UBX domain-containing protein 4.
Protein: PYRC_ENT38
Sequence: MTAQPQVLKIRRPDDWHIHLRDGDMLKTVVPYTSELYGRAIVMPNLAPPVTTVDAAIAYRQRILDAVPTDHDFTPLMTCYLTDSLDPNEVECGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKLGMPLLVHGEVTHAEIDIFDREARFIETVMEPLRQRLQGLKVVFEHITTKDAAEYVRDGNELLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFTRAFLGTDSAPHARHRKEASCGCAGCFNAPTALASYATVFDEMGALEHFEAFASINGPRFYGLPLNETFIELERKESQVEESIALTDDTLIPFLAGEIVHWTVKR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: RS272_HORVU
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGAKKRKKKTYTKPKKQKHKHKKVKLAVLQFYKVDDSTGKVTRLRKECPNADCGAGTFMANHFDRHYCGKCGLTYVYNQKA
What is the function of this protein?
Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.
Protein: YIDC_CYTH3
Sequence: MDKNQIIGISLISVLMLGYFGFMSTQTPETPVTTPPAITQPVQSDTVLLKSAATDTALKAQNQREYGDFAAAMVGEAKEYKLENKDVVVTLSTKGGTIKSVLLKNYFTWDKKQLFLFKQENNQLSLILNTNKKPVDLYSLYYAGVESKAGDKQVVTFKTDAGNGKTIEHTYTLGAAGFTVDYNLKAAGFGGELPNLPLTLDWREQVERIEYDSEQARVKSTVNYMAAEDGFDYLSEASKDRETETLSNVYWVSLKQKFFNSGFYIREGGTIPSATVTAYPMYSTLPNAPVNSEKFIKALEAQVQLPLEAVISGKAAYAFYFGPNDFKICKAVPAENYQKNVNLGWPLVSWINRFVVIPVFDGLKGVFSSFGLIIVILVLLIKLVLLPLSYKSFVSMAKMKALKPELDELKAKHGDDQQAIQMEQMQVYKQFGINPLSGCIPVLLQMPILLAMFNFFPNAIDLRGESLWWATDLSSYDEFAKLPFTIPFYGSHVSMFTLLMTISTLAYTWVNNQVSTVTGPMKYMSYAMPVVFLFVLNSFPAGLSFYYFVSNLVTIAQQLIIRRFVDEGQLRLQLEAKRDKNLSGDTTGGAPKKNRFMARMEEAMKQREQEQQFKKNIKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOF_DESDA
Sequence: MSDVAARLETIRAAHLYRRLRTLSTPQDREVVIDGRRVLLFSSNSYLGLGINAHIRRSAVRALEKFGTGAGGSRLVTGNMTPHMQLESALAAFKGSESALAFTSGYTANMGVISALCHKDTVIFSDALNHASIIDGCRLARGRTVVYAHNDMDDLLEKIRQLRPRQGFIITDGVFSMDGDLARLPELAHIARSYGLTLMVDDAHATGVLGATGRGTLEHFGLSHEDVPVVTGTLSKAIPSEGGFVCGSEILCELLRNTARPFIFTTAPSPAAVAAATAGIGHIAAHPGLVRRLQDNVAYFTGSLAEQGMHVPGQSPIIPIMAGEEEKAVRAAEALLALGVFAPCIRYPTVPRGQARLRLTVMASHTRDDLDHAAVSLRKALAGV
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: PRIO_PANTR
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSSQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.