PharMolix/UniProtQA huggingface dataset:
Protein: CP3AP_MOUSE
Sequence: MELIPNLSIETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFDEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILKVVSRDKPRTGS
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 3A25, CYPIIIA25.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: DSBB_HAES1
Sequence: MLIFFKNLSMKRSTWILLFISALVLESTALYFQHGMGLNPCVMCIYERVAILGILFSGLIGCIAPKWLVLRILALLIGLGSAVKGLLLAIKHLDYQINVYPWNQCAMVPDFPQTLPLDKWFPNIFMPSGSCSDITWSFLGFSMVQWIIVIFACYFLFFIILSISQFKKVRKNRMLFR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMN_IDILO
Sequence: MTNAIDKKVNLLDLNREGIKEFFREMGEKPFRAEQVMKWLYHFCVDDFDEMTNLNKALREKLKQVAEIRAPEVREQQQSSDGTIKFAMTLFDGQDVETVWIPEGDRATLCVSSQVGCALECTFCSTGAQGFNRNLSVAEIIGQVWRVNQLLGAYGKTGIKPVTNVVMMGMGEPLLNLNNVVPAMELMLDDLGFGLSKRRVTLSTSGVVPALEKLRERIDVMLAISLHAPDDELRNEIVPINKKYNIEEFLASSRRYVEQSKAQRKVTVEYVMLDHVNDSTDQAHALAKTLKDTPSKINLIPFNPFPGSDYGRSSNSRIDRFAKVLMEYGLTVMVRKTRGDDIDAACGQLVGDVIDRTKRILKRQQKQRGGEAIAVKTT
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAP1_ARATH
Sequence: MALSMRKAIGVVKDQTSIGIAKVASNMAPDLEVAIVKATSHDDDQSSDKYIREILSLTSLSRGYVHACVTSVSRRLKKTRDWIVALKALMLVHRLLNEGDPLFQEEILYATRRGTRILNMSDFRDEAHSSSWDHSAFVRTYASYLDQRLELALFERRGRNGGGSSSSHQSNGDDGYNRSRDDFRSPPPRTYDYETGNGFGMPKRSRSFGDVNEIGAREEKKSVTPLREMTPERIFGKMGHLQRLLDRFLSCRPTGLAKNSRMILIAMYPVVKESFRLYADICEVLAVLLDKFFDMEYTDCVKAFDAYASAAKQIDELIAFYHWCKDTGVARSSEYPEVQRITSKLLETLEEFVRDRAKRAKSPERKEIEAPPAPAPPVEEPVDMNEIKALPPPENHTPPPPPAPEPKPQQPQVTDDLVNLREDDVSGDDQGNKFALALFAGPPANNGKWEAFSSDNNVTSAWQNPAAELGKADWELALVETASNLEHQKAAMGGGLDPLLLNGMYDQGAVRQHVSTSELTGGSSSSVALPLPGKVNSHILALPAPDGTVQKVNQDPFAASLTIPPPSYVQMAEMDKKQYLLTQEQQLWQQYQQEGMRGQASLAKMNTAQTAMPYGMPPVNGMGPSPMGYYYNNPY
What are the official names of this protein?
Probable clathrin assembly protein At4g32285.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.
Protein: ARSB_RAT
Sequence: MGELSGCTGGSRAGGPGPRLPLLLLLLLWPARASDAAPPPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHMGLQHYLIMTCQPNCVPLDEKLLPQLLKDAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIECLNGTRCALDLRDGEEPAKEYTDIYSTNIFTKRATTLIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYDFIQDKHRRIYAGMVSLLDEAVGNVTKALKSRGLWNNTVLIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGAGFVASPLLKQKGVKSRELMHITDWLPTLVNLAGGSTHGTKPLDGFDVWETISEGSPSPRVELLLNIDPDFFDGLPCPGKNTTPEKNDSFPLEHSAFNTSIHAGIRYKNWKLLTGYPGCGYWFPPPSQSNISEVPSVDSPTKTLWLFDINRDPEERHDVSREHPHIVQNLLSRLQYYHEHSVPSYFPPLDPRCDPKGTGVWSPWM
What is the function of this protein?
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:24311516).  In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (PubMed:24311516).  Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity).
What are the official names of this protein?
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Lysosome. Cell surface.
Protein: RPIA_EXIS2
Sequence: MYEQEKKMLAEAAIKQVKNGMILGLGTGSTTRSFIDALGEWVKAGGEVQGVATSNETVEQAKRLNIPLLSLEEATHIDLVIDGIDQIDPRFRVLKGGGGALFREKVVALMSREILYLADASKFVHHLTGPLPVEIDAFARPYVERYLRDKQLDVTLREHDGQPFVTDGGHLILDVDLERVQDVRHFAQELKSLTGVLETGYFERQPDHVLTVEQGKVRQLAHPNLRDGGGLV
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: Y1788_STAAR
Sequence: MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
What are the official names of this protein?
Putative universal stress protein SAR1788.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP2_PENCH
Sequence: MSDADPFDMSDDDDNSVLSHTPPKKQKKAPTTKKGGSKPLADVENESFMDGIEESNNQDKDTNVSEKYQKLTQLEHIIKRPDTYVGSTERTTQHMWVYSSESEGMEYREVSYVPGLYKIFDEIVVNAADNKQNDKNMDEIRVTIDRESGEISVWNNGRGIPIEMHSKEKMYVPELIFGHLLTSSNYDDTQMKVTGGRNGFGAKLCNVFSTEFTIETQDSRQKKKYKQTWTENMTKMGKAKITDAKGADYTKVTFKPDYAKFGMTGMDDDFEALVKRRVYDLAGTAKVAVKLNGSRIPIRNFKMYMEMYTKAIRRERGDMGPAGKNEIITCSPDPRWEVGFAVSDGAFQQVSFVNSIAITSGGTHVNYIADQICSKLAEQVKKKNKNGATLKPAQIRNHIFIFVNALIVNPAFTSQTKEQLTTKQSQFGSKCVLEEDFYKKILKTEVMTNILHFAQQKADQMLKKTDGGRRSRMNNPKLTDANKAGTKEGHHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIVKVWKGDPKNPTKQRSFFTMPEYEAWKEEHGHERGWEHKYYKGLGTSTTEDAQIYFRDLDRHLKEFHTMQDNEVELIELAFSKKKADERKGNVRQFRPGTFLDHSVDKITYTDFINKELILFSMADNIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQPWFRGFTGEVTAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTTNLVAFDPERITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLSNQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEEDSESGDTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRDLEDFINEWRFQNDEEARRQRKVANMGRRTSSKLMTTGRGGGAAARKRKAALGDDPDDEDFAAPKSKKSAAAKKTESKGGGLLSFLGKSSAKPKPSPADGGDSDDDFDMEIMPKKSRGAPKSEPKADPKPKDEDEDIVMEDSDIEEIIPKKSRGSSKPSVKPESEDGQAKIAEAPKRGRAAAKPKPKPKSEDEEDELDDDDFMEITKAEAAKPSAQPARSGRKTTKYAELSDSDSDNGDDLLGDVSKMVKGIGSTNGASTSDSRLLFSERSRPGSSAGLKTTASKASKPSEFDADETDYSKLVPSNTPRRSLQVKPKDAKVSDDNEPEDDDDEPVKPAAKGKAAAKGKSTAAAANQLLQRLVVGRRKMLPKPPPRLPCPLPQRRTHRSNPRPRRPRRRS
What is the function of this protein?
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.  Topoisomerase II makes double-strand breaks.
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TES_DASNO
Sequence: MDLEAKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSSEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVPAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPEHDQDPSKCHELSPKEVKEMEQFVKKYKNEALGVGDVKLPSEMDAQAPNRICIPGGDRSTTAAVGAMEAKSGEHRRTQYSCYGCKLSMKEGDPAVYAERAGYNKLWHPACFICSTCCELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGEIYVMVNEKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS
What is the function of this protein?
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton.  Plays a role in the regulation of cell proliferation.  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Testin.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Protein: CYSZ_ECOK1
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S35A1_MOUSE
Sequence: MAPARENVSLFFKLYCLTVMTLVAAAYTVALRYTRTTAEELYFSTTAVCITEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELAKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWISVFMLCGGVTLVQWKPAQATKVVVAQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLAGTYLSDGAEIQEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVLLFGLQITLSFALGALLVCVSIYLYGLPRQDTTSIQQEATSKERIIGV
What is the function of this protein?
Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:8755516, PubMed:10085119, PubMed:30985278, PubMed:34015330).  Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278).  Also able to exchange CMP-sialic acid for AMP and UMP (By similarity).  Also mediates the transport of CDP-ribitol (PubMed:34015330) (By similarity).
What are the official names of this protein?
CMP-sialic acid transporter, CMP-SA-Tr, CMP-Sia-Tr, CST, Solute carrier family 35 member A1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: ARGJ_STAS1
Sequence: MRDIETIDTLNQLNIDLQGDVSSPLGFIAGGLHCGLRRKKVDFGWIYSTTPATATGVYTLNQFKAAPLKLTEDSINKDKALQAIIVNSAIANACTGEKGMQDALDTQAWIAEQLNIEQHLVGVASTGVIGSFLPMDKIQYATQHVLKEQYNKSEAFNQAILTTDTMTKHLSVKVEIDGTTVTIGGTAKGSGMIHPNMATMLGFITTDANIDANTLDYCLKQSIDQSFNMITVDGDSSTNDMVLCMANGQAQHTQIDALHPEWHKFVYALNFVCHYLAKSIAKDGEGATKLVTVKVKGAHDVVEARKIAKSIVSSNLVKTAVHGEDANFGRIVTAIGYASRYIEPSATHVSLCQVSVLEKGMAVDFDEQRLKEELASDNILIEATVGNGEGEAAAYGCDLSYEYVRINASYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_THIDA
Sequence: MADPLQHKGAAKTSRIPIKIVPQERQRLPPWIRAKAPSLPNVGRLKGILREAKLHTVCEEASCPNLGECFGHGTATFMILGDLCTRRCPFCDVGHGTPLPPDADEPRHLAETIALMALKYVVITSVDRDDLRDGGAGHFAECIAAVREKSPATRIEILTPDFRGRLDKALAALDRAPPDVMNHNLETVPRLYKAARPGADYAHSLKLLQDFRTRHPDIPTKSGLMLGLGETDDEILEVMRDLRAHGVDMLTLGQYLQPSRHHLAVLRFVTPERFAQFEQEALAMGFRHAACGPMVRSSYHADQQAAAAAAG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_LACLM
Sequence: MKRTNYAGNITEEYLNQTITVKGWVAKRRNLGGLIFIDLRDREGIVQIVVNPETAATEVAEAADKARNEFVLEVTGKVVERASKNDKIKTGGIEIEATAIEILSTSKTTPFEIKDDVEVLDDTRLKYRYLDLRRPEMLKNITMRHATTRSIREYLDGAGFIDVETPFLNKSTPEGARDYLVPSRVNKGEFYALPQSPQLMKQLLMTAGLDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLGEEEIQELTEELIAKVMKDVKGIDVTLPFPRMNYDDAMNFYGSDKPDTRFELLLTDLSALAKTVDFKVFQEAEVVKAIVVKGAADKYSRKSIDKLTEQAKQNGAKGLAWVKFEKGEFAGGVSKFLAESTDSFVNELKLTDNDLVLFVADSLDVANSALGALRLTIGKQQGLIDFRKFNFLWVIDWPMFEWSDEEERYMSAHHPFTLPTKETQAFLSADGHRKDSDLKKVRAHAYDIVLNGYELGGGSLRINSRDLQEEMLSALGFKLEDANEQFGFLLEALDYGFPPHGGLALGLDRFVMLLAGKDNIREVIAFPKNNKASDPMTQAPSIVADKQLEELSIKLANKDQ
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RND2_HUMAN
Sequence: MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGMQRSAQLSGRPDRGNEGEIHKDRAKSCNLM
What is the function of this protein?
May be specifically involved in neuronal and hepatic functions.  Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
What are the official names of this protein?
Rho-related GTP-binding protein RhoN, Rho family GTPase 2, Rho-related GTP-binding protein Rho7, Rnd2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.
Protein: GATF_KOMPG
Sequence: MFRTAVRNYSSRVGQKFQSLEQIKEYLKKPTWDTKTLLKGSQKSLEIDTPKLHRLLQLSGLSTDLDAGKERQLLNDLNAQLTMMNKLQEIECKEFDLIETQHSPLKFQDIRNATGELRQSSKKGETGQWNPLDLASVKSEGFYVVNEKLGKE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  Required for proper protein synthesis within the mitochondrion.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial, Glu-AdT subunit F.
What is the protein family that this protein belongs to?
Belongs to the GatF family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: IF2G_ARCFU
Sequence: MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEPPEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVIAQNKIDIVSRERVLENYQEIKEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKPGTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEATPGGLVGIATKLDPTLTKSDALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVEKIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCADKGSRVAISRRVGSRWRLIGAGIIR
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: ARGB_CORU7
Sequence: MPKIHDSSCTSGLTPSQRSHVLAEALPWLLHYRDKIVVVKYGGNAMIDDELKRAFAADMVFLRAVGARPVVVHGGGPQINMMLDKVGLEGEFRGGFRVTSPEVMEYVRMVLFGKVGRELVGLINEHGPYAVGASGEDAGLFTAEKFQPEIEGELVDIGRVGSITDVDPTSLFDLIDAGRIPVVSTIAPDDDGLVYNINADTAAGALAGALDAERLVMLTNVPGLYTDWPNKDSLVSSLTPAELEELLPTLDSGMIPKMTACLDAIHNGVKAAHVIDGRVPHSVLLELMTEGGIGTMISSESYEH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_METPB
Sequence: MTTDVRILGIDPGLRRTGWGLITARGTKLSYLACGVVTSDGDLPLALRLRELHEGLTRVLTTHAPDEVSVEETFVNKDAQATLKLGHARAVALLVPALAGLPVAEYAANLVKKTVAGNGHAEKVQIQAMVKFLLPKAEFKLADAADALAIAITHASHRGAIALDRRHAVAAGSGPGAARIAAALARLDR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: MNME_STRA1
Sequence: MSITKEFDTIAAISTPLGEGAIGIVRISGTDALKIASKIYRGKDLSAIQSHTLNYGHIVDPDKNEILDEVMLGVMLAPKTFTREDVIEINTHGGIAVTNEILQLILRHGARMAEPGEFTKRAFLNGRVDLTQAEAVMDLIRAKTDKAMDIAVKQLDGSLKTLINNTRQEILNTLAQVEVNIDYPEYDDVEEMTTTLMREKTQEFQALMENLLRTARRGKILREGLSTAIIGRPNVGKSSLLNNLLREEKAIVTDIEGTTRDVIEEYVNIKGVPLKLVDTAGIRDTDDIVEKIGVERSKKALEEADLVLLVLNSSEPLTLQDRSLLELSKESNRIVLLNKTDLPQKIEVNELPKNVIPISVLENENIDKIEERINDIFFDNAGMVEHDATYLSNARHISLIEKAVDSLKAVNEGLELGMPVDLLQVDMTRTWEILGEITGDAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATS_BOVIN
Sequence: MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI
What is the function of this protein?
Thiol protease.  Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation.  The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
What are the official names of this protein?
Cathepsin S.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
Protein: AZOR_AZOSB
Sequence: MNILQINSSARSEGANSTRVANDVTTRLLAANPDATVTVRDLAKNPVPVLDEAALGALFAPVESRSTDQAARVAASDALIAEVQAADVLVLGVPMYNFTVTAQFKNWIDAIARAGVTFRYTANGPEGLLKGKTVYVALARGGQYRGSPLDTQVPYLKAVLGFLGITDVRFIYAEGLNMGPEAAAKGFAQAAADLDAALAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: DBP6_PICST
Sequence: MFGARFDPTADDSSSDESEEESEEEENENENVVNNDVAKDIDSVESEESEDSDHSNDPNDAMDVDSEVNTEVDVDYVSKYKSVFDKFKKSVPETKKIDSESSSEEEDDVEMQDLMPLPQPALPRDKRLISSNSHLKNLDWLATPIYASPEDSKPFSEFEISPFLLKNLERDNFTTAFSVQIAIMDILLHDIKRNRLEPDVKGDILVNAATGSGKTLAYSIPIIEALHNRVVPRVRAIVLVPTKPLINQVKATFVQLSRGTNLSVVSLRNDVSIKEEGIKIVNSPPDIIVSTPGRLVEHISNKSINLNSLQFLVIDEADRLLNQSFQNWCQVLISSLEGDVNIAEEWKITPQKLIFSATLTTDSGKLSALKFQKPRLVIVNDRKQLVNEIFNVPSSLSEYTIQFGTAKASIKPLILAKYLLENNKLSNVLIFTKSNEASIRLCKLLELMFGKLHPSMNIAYINSTNNKSAIRTKILKDFSTQKINILVATDLIARGIDILSITDVINYDLPNSSREYVHRVGRTARANQTGHAYTLCFGKGEAKWFKKIISDVGRGDKTIEKVEIELKELIVAEDENVYNECLESLSKQVFH
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP6.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TCAA_STAAC
Sequence: MKSCPKCGQQAQDDVQICTQCGHKFDSRQAFYRKSTDEDIQTNNIKMRKMVPWAIGFFILILIIILFFLLRNFNSPEAQTKILVNAIENNDKQKVATLLSTKDNKVDSEEAKVYINYIKDEVGLKQFVSDLKNTVHKLNKSKTSVASYIQTRSGQNILRVSKNGTRYIFFDNMSFTAPTKQPIVKPKEKTKYEFKSGGKKKMVIAEANKVTPIGNFIPGTYRIPAMKSTENGDFAGHLKFDFRQSNSETVDVTEDFEEANISVTLKGDTKLNDSSKKVTINDHEMAFSSSKTYGPYPQNKDITISASGKAKDKTFTTQTKTIKASDLKYNTEITLNFDSEDIEDYVEKKEKEENSLKNKLIEFFAGYSLANNAAFNQSDFDFVSSYIKKGSSFYDDVKKRVSKGSLMMISSPQIIDAEKHGDKITATVRLINENGKQVDKEYELEQGSQDRLQLIKTSEK
What is the function of this protein?
Plays a major role in decreasing resistance to glycopeptide antibiotics.  Overexpression confers oxacillin hypersusceptibility, without affecting the levels of resistance towards vancomycin.  Could be involved in virulence.  Overexpression increases the levels of teicoplanin susceptibility.  Overexpression also increased susceptibility to oxacillin in methicillin-resistant strains.
What are the official names of this protein?
Membrane-associated protein TcaA, Teicoplanin-associated protein A.
What is the protein family that this protein belongs to?
Belongs to the TcaA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y957_STAAN
Sequence: MTKYTFKPKDFKAFNVEGLDARMEALNEYIRPQLHELGEYFSDFFTSQTGETFYPHVAKHARRSVNAPKDTWVAFATSKRGYKMLPHFQIGMFEDQLFVMFGIMHEAKDKATRAKVFERKFKAIQQLPDDYRVCLDHMKPDKPFIKDLTDDDLKEAIQRAINVKKGEFFIARAITPQDKRLKSDKAFIAFLEETFDQFLPFYSA
What are the official names of this protein?
UPF0637 protein SA0957.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.