PharMolix/UniProtQA huggingface dataset:
Protein: HYDA_PSEAE
Sequence: MSLLIRGATVVTHEESYRADVLCANGLIQAIGENLETPSGCDVLDGGGQYLMPGGIDPHTHMQLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFHTWRGWAQKSAADYGFHVAITWWSDEVAREMGELVAQHGVNSFKHFMAYKNAIMAADDTLVASFERCLELGAVPTVHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEAASRAIRIAETLGTPLYLVHISSREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDWATAAGYVMSPPFRPVEHQEALWRGLQSGNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTAGIEDRMALLWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQGSRTLSAATHHQRVDFNIFEGRTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVERPAYPSVYEVLGRRAERQRPVAVER
What is the function of this protein?
Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids.
What are the official names of this protein?
D-hydantoinase/dihydropyrimidinase, DHPase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Protein: YDIB_SALEP
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPYTYMAFEVDNTTFASAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIRGKTMVLLGAGGAATAIGAQAAIEGIKEIKLFNRKDDFFEKAVAFAKRVNENTDCVVTVTDLADQHAFTEALASADILTNGTKVGMKPLENESLIGDVSLLRPELLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFELWTGKAFPLDYVKQVMGFTA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: BSHC_THET8
Sequence: MEAACLVRSLGLPQGEEALKARLRRPGHPRLREALAAYLKRLQAPEEAFRALERLEVGAVVTGQQAGLLGGPALTFYKAHTALCLADRAGAAGVFWVASQDHDVEEVRHLHLLRDEVPETLSLDLPPLPSGRIPLAPHRERLRAFLGPWAKDYRLGYALEAETLSEFFARVLLAFLGERGLVPFDPMAEELAPLFLEALERELSDPLGSAEAINREAERIRALGGKPPLRRKPGATNLFLETDQRRLLFYEGGAFTDGVRRYTAKELWEIARADPSRLTPAAGLRPVFQDLVLPTAGFVVGPNELRYVAELSGVYARYGLAMPALFLRAFGVVVEPPVRRILEKYRLDPWAFVDEGEAAFLRAAEAWLAPFRAFRDRVEGLLQEASRLVEEAEALEPNLVRPLRRFRARVGGEAERLRRKLLAAQAARDEVLARHLGRLKVHLLPFGLPQERVYPYAMYALRHGEALRRLAEAPWEGRVALYLG
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: ATPE_AGRST
Sequence: MKLNLYVLTPKRIIWDCEVKEIILSTNSGQIGVLPNHAPINTAVDMGPLRIRLLNDQWLTAVLWSGFARIVNNEIIILGNDAELGSDIDPNEAQQALEIAEANLSKAEGTKELVEAKLALRRARIRIEAVNWIPPSN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS17_CORU7
Sequence: MSEANVNKKEKGQKKVRTGYVVSDKMAKTIVVELEDRKQHALYGKIMRRNSRVKAHDEEGLAGVGDRVRIEETRPLSKDKHFRLLDIVEKAR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RECF_CALS4
Sequence: MYLKEIFVDNFRNLKKQKLEFCEGVNLIYGLNAQGKSNLLEAIRLLSMGRSFRGSKMSELVKFDEEYFYVRGLVRSADFYEKKIEFGYKVNGNKVIKVNGNKLKSTGEILGHFLTVIFSPEDIEIIKEGPSRRRKYLDACISVIDKNYFFDLLQYNKTLSNRNSLLKKIKEEGKGEDLLEIFDEKLAEYGARIIKVRNNYLEKLKNSMSKFLMEISNEKLEIIYLNSAGVKEVHEENLIREKLKNRLTKSLTLDLKYLSTQVGPHREDFKILINGYDSRVYSSQGQKRTAALCLKLSELEILEEETGEKPVLLLDDVMSELDDNRKKYILKKLEGFQSFITHTSKSDVEGDCCFKIYDGIVMRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CZCS_CUPMC
Sequence: MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEHFLREVDGVQGVPAAQHRFDDLVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGKSSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTTLVLGTTVGVILTALVGAAITRRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFSADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADSANVALELTELQLNAELRKLSAYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNAVRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLIFDRFFRGDRARSNSSQSTGLGLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG
What is the function of this protein?
Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis.  Probably activates CzcR by phosphorylation.
What are the official names of this protein?
Sensor protein CzcS.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PSBN_CUCSA
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATPG_VIBPA
Sequence: MAGAKEIRNKIGSVKSTQKITKAMEMVAASKMRRSQDAMEASRPYAETMRKVIGHVANANLEYRHPYLEEREAKRVGYIIVSTDRGLCGGLNINVFKKAVTDIQTWKEKGAEIELAVIGSKATAFFKHGGAKVAAQVSGLGDSPSLEDLIGSVGVMLKKYDEGELDRLYVVFNKFVNTMVQQPTIDQLLPLPKSDSKEMQREHSWDYIYEPEPKPLLDTLLVRYVESQVYQGVVENLACEQAARMIAMKAATDNATNLIEDLELVYNKARQAAITQELSEIVGGASAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACCA_TRIEI
Sequence: MPKSERKILLDFEKPLAELENRINQIRELAKDCSSVDVSEQIYQLEAKATQLRQEIFSSLSPVQKLQLARHPRRPTSLDYIQAISDEWIELHGDRGGSDDPAIVGGLARVNGRPVVIIGHQKGRDTKDNVARNFGMASAGGYRKSIRFMEHGNRFGMPILTFIDTPGAWPGIEAERLGQGEAIAYNLREMFHLDVPIICTVIGEGGSGGALGVGVGDRLLMLEHSIYTVASPEACAAILWKDASKASQAAEALKITSWDLKKIGIIDDVVPEPSGGAHANPLQAAENLKTAIVKSLDDLNHLSSPQRRKKRYQKFRSMGVFLET
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_DEIRA
Sequence: MPKSALMSSSFQTSVSPRPLPVSCASRTAARKLSLYCSEGRTRCGMGQGKGWRWPGHRPPGLPSPTNRVGQSVPKWRPQPHKAAGGGRTIRDVKEAAFDVLDLGLLPYPQAWARQKQELARVAVGGRPTLLLVEHPAVLTLGRKAQEGENIVVTREYLAAQGIDVFAVERGGDVTYHGPGQLVAYAIFPVGRRVRDFLRLLENAVVTALGTLGLPDARPNPGYAGVYVDPREINGKTYDQKICSIGVAIKQNVALHGIGLNVCTNLDHFDLIVPCGLTDTQMTSVQREYDLRGLGSVSMEQAKKALTDAFALTFADYDWSLPGVAAGQEALSVASP
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN139_MOUSE
Sequence: MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD
What is the function of this protein?
E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death.  Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER).  Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression.  Involved in the sterol-accelerated degradation of HMGCR.  This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane.  In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR.  The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction.  Required for INSIG1 ubiquitination.  May be required for EIF3 complex ubiquitination.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF139, RING finger protein 139, RING-type E3 ubiquitin transferase RNF139, Translocation in renal carcinoma on chromosome 8 protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS2_TRIEI
Sequence: MPVVSLAQLLESGVHFGHQTRRWNPRMSQYIFTERNGVHIIDLVQTAQLMDEAYNYIRTASEQGKKFLFVGTKRQAAGIIAQEATRCGGYYINQRWLGGMLTNWTTIKTRVERLKDLERREESKALDLLPKKEASVLRREMAKLQKYLGGIKNMRRLPDGVIMVDQRREYNAVQECQKLNIPIVSLLDTNCDPTQVDIPIPANDDAIRSIKLIVGKLADAIYEGRHGQLEADYEDYYEDYEEYEDDYEGAEGDLDLDSANEEESLEDNNEEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NIKR_SULIK
Sequence: MSAEKISISLPKELYRELEDFITRKGIPDRSKIFQIALRNYLDENREGTEIIYGIINLVYDHEEASEALTEIQHEYKDNIISTLHLHVNERLCIEAIAVKGEKSKLVELNNRLGQIRGILKARLLISFPYEKT
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: CYOE_KLEP7
Sequence: MFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLGGYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVPDSHSLLAYVR
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPG_BUCAI
Sequence: MTSTKEIKNKIVSVTNTKKITKAMEMVAVSKMRKTEERMRSGRPYSDIIRKVIDHVTQGNLEYKHSYLEERKTNRIGMIIISTDRGLCGGLNTNLFKQVLFKIQNFAKVNIPCDLILFGLKSLSVFKLCGSNILAKATNLGENPKLEELINSVGIILQEYQCKRIDKIFIAYNKFHNKMSQYPTITQLLPFSKKNDQDASNNNWDYLYEPESKLILDTLFNRYIESQVYQSILENIASEHAARMIAMKTATDNSGNRIKELQLVYNKVRQANITQELNEIVSGASAVSID
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y488_HAEIN
Sequence: MLDYEIFNPYEGLIFDMDGTLIDTMPVHAQAWTMVGKKFGYEFDFQIMYNFGGATVRTIAGEMMKAANMPLDRIEDVLAAKRELSYQLIPTQSKLLPTFEIVKSFHQKKPIALGSGSHRKIIDMLMDKLAIAPYFNAIVSADDVKEHKPHPETFLRCAELIQANPSRCIVFEDADLGVQAGLSAGMDVFDVRTREIISPR
What are the official names of this protein?
Uncharacterized protein HI_0488.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: HUTH_BRUA4
Sequence: MTLVLKPGSVPLETLETIYREGLPVRIDPAFHAGVEKAAARIAEIAAGDEPVYGINTGFGKLASIRIAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLISLGRGASGVRLEVITLIEDMLKKGVIPMIPEKGSVGASGDLAPLAHMTAAMIGEGEAFYKGERLPSAKALEKAGLKPVVLAAKEGLALINGTQTSTALALAGLFRAHRAAQTALITGALSTDAAMGSDAPFHEEIHTLRGHKGQIDAGRALRALLEGSVIRQSHLEGDQRVQDPYCIRCQPQVDGACLDILRQAARTLEIEANAVTDNPLILSDGRAVSGGNFHAEPVAFAADQIALAVCEIGAISQRRIALLVDPALSFGLPAFLARKPGLNSGLMIAEVTSAALMSENKQMAHPASVDSTPTSANQEDHVSMACHGARRLLQMTANLNAIIGIEALTGALGVELREPLTTSPELAKVIAVLRGKVPTLEDDRYMADDLKNAAELVVDGALAGAVSSGILPSLEA
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_EHRRG
Sequence: MQGLYIKSYGCQMNVYDSLIIENIIKPLGFSIVNELSEADIVILNTCHIREKAAEKLYSELGRIRKIQETKNLTIVVAGCVAQAEGTEIFTRAPFVDIVVGPQSIHTLPELIVKARKIKKQIINIDFPVISKFDAIAVEEYTKNQKVSAFISVQEGCNKFCSFCVVPYTRGEEYSRTVEAIFKEALILADSGIKEITLIGQNVNAYHGTYKGNEWDLGRLIQHIAKISSIERIYYTTSHPRDMHESLYEAHGIEKKLIPFIHLPVQSGSNKILRKMNRKHTAEEYINIIKTLRKHRSDIAYSSDFIVGFPGETDEDFENTIRLIEEVKFSQAYSFKYSPRPGTPSAEYTSQIPDEIKSQRLTKLQELVHKQQLEFNKKMIGETHPVLFYKKGKFDNQIIGKTPYMQSCYINTENPDLYYNKIVPIKITDAHKNHLTGIIPHTLPV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAPD_AGGAC
Sequence: MYAIAFDLEISELKKHYGDPYNNAYFEVKSELEKIGFEWTQGSVYLSKDPRNNLATVYKAINLLSNIDWFKHSVRDIRAFKVEDWSDFTEIVKTS
What is the function of this protein?
Cleaves ssRNA, mostly between U:A.
What are the official names of this protein?
Endoribonuclease VapD homolog, Virulence-associated protein D homolog.
What is the protein family that this protein belongs to?
Belongs to the VapD ribonuclease family.
Protein: DXS_BURCJ
Sequence: MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHKILTGRRDQMHSLRQYDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEEFGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVFGEWLCDEAERDTRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVATVKEFTEIPLGKGEVRRRTSQPEGKRVAILAFGTMVAPSLAAAEELDATVANMRFVKPVDAALVRELAETHDYVVTVEEGCVMGGAGSACVEALMESGVIRPVLQLGLPDLFIDHGDPAKLLSQCGLDGAGIAKSIRERFLNPAADVAGQAKRVA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: BLA2_ECOLX
Sequence: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
What is the function of this protein?
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
What are the official names of this protein?
Beta-lactamase SHV-2, SHV-2A.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: PGK_SPHAL
Sequence: MTAFKTLDDIGDVTGKRVLVRVDLNVPMIDGAVSDATRIQAAMPTIRELSDKGAIVLLLAHFGRPKGAKNPTQSLSLVMGGVEDVLGHSVMFIPEAVGEGAKAGVAVLAPGDVAVLENTRFYPGEEQNDPAFADALAEIGDLYVNDAFSAAHRAHGSTEGIARRLPAYAGRAMEAELKALDAALGNPVQPVAAVVGGAKVSSKIDVLRNLVGKVDHLIIGGGMANTFLAARGVDVGRSLCEHELVDTANAIFDAADAAGCTIHLPYDVVVAKEFAPNPPTRTVNVHEVAADEMILDVGPAAIEALADVLKNCRTLVWNGPLGAFETPPFDTATVALARTAAALTREGSLTSVAGGGDTVAALNHAGVAGDFTFVSTAGGAFLEWMEGKPLPGVDALKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG13_HUMAN
Sequence: MKCVFVTVGTTSFDDLIACVSAPDSLQKIESLGYNRLILQIGRGTVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEGHLFYCTCRVLTCPGQAKSIASAPGKCQDSAALTSTAFSGLDFGLLSGYLHKQALVTATHPTCTLLFPSCHAFFPLPLTPTLYKMHKGWKNYCSQKSLNEASMDEYLGSLGLFRKLTAKDASCLFRAISEQLFCSQVHHLEIRKACVSYMRENQQTFESYVEGSFEKYLERLGDPKESAGQLEIRALSLIYNRDFILYRFPGKPPTYVTDNGYEDKILLCYSSSGHYDSVYSKQFQSSAAVCQAVLYEILYKDVFVVDEEELKTAIKLFRSGSKKNRNNAVTGSEDAHTDYKSSNQNRMEEWGACYNAENIPEGYNKGTEETKSPENPSKMPFPYKVLKALDPEIYRNVEFDVWLDSRKELQKSDYMEYAGRQYYLGDKCQVCLESEGRYYNAHIQEVGNENNSVTVFIEELAEKHVVPLANLKPVTQVMSVPAWNAMPSRKGRGYQKMPGGYVPEIVISEMDIKQQKKMFKKIRGKEVYMTMAYGKGDPLLPPRLQHSMHYGHDPPMHYSQTAGNVMSNEHFHPQHPSPRQGRGYGMPRNSSRFINRHNMPGPKVDFYPGPGKRCCQSYDNFSYRSRSFRRSHRQMSCVNKESQYGFTPGNGQMPRGLEETITFYEVEEGDETAYPTLPNHGGPSTMVPATSGYCVGRRGHSSGKQTLNLEEGNGQSENGRYHEEYLYRAEPDYETSGVYSTTASTANLSLQDRKSCSMSPQDTVTSYNYPQKMMGNIAAVAASCANNVPAPVLSNGAAANQAISTTSVSSQNAIQPLFVSPPTHGRPVIASPSYPCHSAIPHAGASLPPPPPPPPPPPPPPPPPPPPPPPPPPPALDVGETSNLQPPPPLPPPPYSCDPSGSDLPQDTKVLQYYFNLGLQCYYHSYWHSMVYVPQMQQQLHVENYPVYTEPPLVDQTVPQCYSEVRREDGIQAEASANDTFPNADSSSVPHGAVYYPVMSDPYGQPPLPGFDSCLPVVPDYSCVPPWHPVGTAYGGSSQIHGAINPGPIGCIAPSPPASHYVPQGM
What is the function of this protein?
May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.
What are the official names of this protein?
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13, Asparagine-linked glycosylation 13 homolog, Glycosyltransferase 28 domain-containing protein 1, UDP-N-acetylglucosamine transferase subunit ALG13 homolog.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
[Isoform 2]: Endoplasmic reticulum. Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14.
Protein: CUTI2_MAGO7
Sequence: MQFSLSIATAILAATASAMPVLETRQTVGTTANEFTSGGCKDVVLLYARGTTQAGNMGQEPGPELGNALKARLGAARVAVQGVAYSASLLGNLNPGGAPANEATSFRTLIGQVASQCPNARIVVSGYSQGAALVHRAVEGATAAVRARIAAGVTFGDTQKQQDGGRIPGLDASKTLIICNTGDRVCEGTLIITAAHSGYGARAGEAVDFIAARV
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (PubMed:17704215).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (PubMed:17704215).  Required for efficient penetration of the host plant cuticle by the appressorium during the initial stage of fungal infection (PubMed:17704215).
What are the official names of this protein?
Cutinase CUT2.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS3_PELPD
Sequence: MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGEESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPAQVYKK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL4RA_MOUSE
Sequence: MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWACLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEVPVGALGIAVS
What is the function of this protein?
Receptor for both interleukin 4 and interleukin 13.  Couples to the JAK1/2/3-STAT6 pathway.  The IL4 response is involved in promoting Th2 differentiation.  The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.  In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
What are the official names of this protein?
Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 4 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.