PharMolix/UniProtQA huggingface dataset:
Protein: RLA0_NEUCR
Sequence: MGGKSANKAGYFDKLKGLLEDYRSIFIVSVDNVSSQQMHEIRQSLRGEAVVLMGKNTMVRRALKTFVADTPEYERLLPFVKGNVGFVFTNGDLKEVRDKILANKVAAPARAGAIAPADVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGAKVGPSEATLLNMLNISPFTYGMGIAQVYDQGNTFPSDVLDISEEQLLKAFSTAITTIASLSLALNFPTLPSVIHSVVNAYKKVLAVAIETEISWPEIEELKDRIANPEAYASAAPAASTEAAPAAGKAEEKEEEKEESDEDDGGFGGLFD
What is the function of this protein?
Ribosomal protein P0 is the functional equivalent of E. coli protein L10.
What are the official names of this protein?
60S acidic ribosomal protein P0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y2961_BURMS
Sequence: MIIVLSPAKSLDYETPPHVSHHTQPQFADDAAALIDELRRLSPQQIATLMSISDPLARLNFQRYADWSRASTPANAKQAVLAFNGDVYEGLDARSLSPDDLDYAQRHVRVLSGLYGLLRPLDLLQPYRLEMGTRFSNARGKDLYAFWGERITHALNAELKTRVGASRVLVNCASAEYFKSVKPKLLDARVVTPVFEDWKDGRYKIISFHAKRARGLMARYVVEGRIDSPDALKDFASEGYAFDASASNDDTYVFRRRAGA
What are the official names of this protein?
UPF0246 protein BMASAVP1_A1161.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RRP17_YEAST
Sequence: MAVHTNRQILTRGKNYATKQSKKFGTDEVTFDKDSRLDYLTGFHKRKLQRQKKAQEFIKEQERLRKIEERQKIRQERKEVMEEQLKTFKESLNLEAEIEDAKNDKTEDLQVESDESWHGFDSDKDDGDNDNNESSVKPILKKGAITEIYDDSTTVELETLEPNDNFEYLAQLNNVKLEKAEKVLKQSINRATKYAKFLGVDEKQKKKPRVKKFRYLTKNERRINQRKANDNKRRR
What is the function of this protein?
Essential protein involved in ribosomal RNA processing.
What are the official names of this protein?
Ribosomal RNA-processing protein 17.
What is the protein family that this protein belongs to?
Belongs to the RRP17 family.
Protein: METJ_ECO27
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_DESHD
Sequence: MRIMGLDFGERTIGVAVSDAMLLTAQGVKTIRRSPKELEELKTMLQDYEVDHIVLGYPKNMNGTLGPRAQATEEFAQILKEEFGLPVTLWDERLSTMGAQRSLLEADVSRAKRKQVIDKMAAVFILQGYLDYIRQKNGQNKE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_NEIG1
Sequence: MTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDSIRGKHRLNLPAVIAEIKKASPSKGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEYLKQAREAVLLPVLRKDFIIDEYQVYQARAWGADAVLLIAAALEQGQLERFEALAHELGMTVLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGKADVEFMRARGVHTFLIGETFMRADDIGAEVGKLF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: SECA_FRATW
Sequence: MLSLVQKIIGSRNERFIKKVSRIVQKINSLEPEFEKLSDEQLKAKTFEYRERLANGEILDNLLPEAFATVREAGKRTKNMRHYDVQLIGGIVLHQGKVAEMRTGEGKTLVATLPAYLNALTGDGVHVITVNDYLAKRDAELMSDIYEFLGMSVGVIVADLNPQQRKEAYACDITYGTNNEFGFDYLRDNMAYEKEQQVQRSRNYVIIDEVDSILIDEARTPLIISGASDDSSEMYNLFNRLVPYLEKQEKEEVENEQEQRDFYVDEKSKNAYLTEKGYAKIENMLKKEGILEEDDNLYSPHNITKMHYLNACLRAHSLYQLNIDYIVRDQEIVIIDESTGRAMPGRRWSDGLHQAIEAKEGVKVNAENQTMASITFQNFFKLYNKIAGMTGTADTEAFELHSIYGLEVIIIPTNKPMIRKDHHDEIYGSVSEKFDAIVEDIKERISKGQPVLVGTASIEASEVLSTLLKKKKIRHNVLNAKQHEKEASIIAMAGYPDNVTIATNMAGRGTDIILGGNLEVEIAQLEDPTPEDIAQIKAEWLKRNEAVKKAGGLCIIGSERHDSRRIDNQLRGRAARQGDPGESKFYLSMDDNLLRIFASQSMAERVKKGLKGGESLAFGFMSKVISKAQGKVESYHFDIRKNLLEYDNVVNTQRKVIYEQRQSFLEAEDVSDILADIRIDVAEQLFHDYVPAGSMHELWDLEGLEKALKSDFMIELDLQKLYEEDDSLGEEDLKRLVREAIEIEFVEKTKNLDSGAVRQFEKFSLLQSLDTHWREHLSSIDHLRNSINLRGYAQKDPKNEYKKEAFELFSTMLDNFKYEVISSLAKIRIATEEETQRAQQEWQESMSDIKAEHESVIDNNQRHDEDEQEEAPKVQQVRREGPKVKRNDPCPCGSGKKYKQCHSKVE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: VATA_THEAC
Sequence: MGKIIRISGPVVVAEDVEDAKMYDVVKVGEMGLIGEIIKIEGNRSTIQVYEDTAGIRPDEKVENTRRPLSVELGPGILKSIYDGIQRPLDVIKITSGDFIARGLNPPALDRQKKWEFVPAVKKGETVFPGQILGTVQETSLITHRIMVPEGISGKVTMIADGEHRVEDVIATVSGNGKSYDIQMMTTWPVRKARRVQRKLPPEIPLVTGQRVIDALFPVAKGGTAAVPGPFGSGKCVSGDTPVLLDAGERRIGDLFMEAIQDQKNAVEIGQNEEIVRLHDPLRIYSMVGSEIVESVSHAIYHGKSNAIVTVRTENGREVRVTPVHKLFVKIGNSVIERPASEVNEGDEIACASVSENGDSQTVTTTLVLTFDRVVSKEMHSGVFDVYDLMVPDYGYNFIGGNGLIVLHNTVIQHQLAKWSDANIVVYIGCGERGNEMTEILTTFPELKDPNTGQPLMDRTVLIANTSNMPVAAREASIYTGITIAEYYRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLGRRVSEFYERSGRARLVSPDERYGSITVIGAVSPPGGDISEPVSQNTLRVTRVFWALDAALANRRHFPSINWLNSYSLYTEDLRSWYDKNVSSEWSALRERAMEILQRESELQEVAQLVGYDAMPEKEKSILDVARIIREDFLQQSAFDEIDAYCSLKKQYLMLKAIMEIDTYQNKALDSGATMDNLASLAVREKLSRMKIVPEAQVESYYNDLVEEIHKEYGNFIGEKNAEASL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: ZN217_HUMAN
Sequence: MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIEGYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKEKNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNGKSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTKKTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQLATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPSVDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTCSPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQDTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQDFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLEVSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTFYPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSEMFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYFCNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCVYPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQHLSNSMAQKRNYENFIGNAHYRPNDKKT
What is the function of this protein?
Binds to the promoters of target genes and functions as repressor.  Promotes cell proliferation and antagonizes cell death.  Promotes phosphorylation of AKT1 at 'Ser-473'.
What are the official names of this protein?
Zinc finger protein 217.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein: DNLI_MYCTA
Sequence: MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
Probable DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: DCN1_EMENI
Sequence: MPPYTAAQKQQITQFVSFTQANNTTAAKFLRQSRWNTEEAIDAFKNRIAPASMGLIFRPCATAGVREAVLRISIFQKLIPGLPAGNDALADWVLYLYGFTFLLKEFRDSPEENPDTIGIEGAMRYLGDIEVELDEVTCLAIAELLQSPSMGEFTREGFLNGWRSVQCDSIAKMAAHAANLRTRIPSEPDLFRRVYRYTFPLCLVQGQRNLQFEIAVEQWNLFFTTPKGGIAWNTTTTPWLDWWVEFLEERGKKPVNKDLWQQVEVFMRKTHEDEAFGWWSEDGAWPGTLDDFVAWVRKKRGDEGAMEE
What is the function of this protein?
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.  Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
What are the official names of this protein?
Defective in cullin neddylation protein 1.
Protein: IF3_LEPBL
Sequence: MQRKPSQKSATDKLFNHRINEKITGVSRVRLVSDDGVAIVSFEEALRKAKEENLDLVEVSADQELHVCKIIDYGKYKFELLKKNKEAKKKQHVINVKEIKIRPRIESHDYEIKKKHAQEFLGKGDKVKVSLRFRGREMMHSDLGMKVVYRMIEDLKEYGLAERDPIQDGKQIVVIINPK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGR2B_DANRE
Sequence: MTAKTLEKAPVSLGGFVHPLADSIYSVDELGTTLPASVTIYNDLGGHYEQINAGDGLINGDMSTEKRALDLAYSSTFAQPAGPRNQTFTYMGKFSIDSQYPGNWNPEGVINIVSAGILGMTQPSSASSSPASSVSPSHFSSTLSCTMAQNQADMEHIYSPPPPYSGCGEVYQDPSAFLSTSTCPISYPPPSYSSPKPNADSGLFPIIPDYAGFFQPPCQRDMQSMPDRKPFSCPLDSFKLPPPLTPLNTIRNFTLGGPGPDGPRLPTAYTPQNLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHTKIHLRQKERKSSSSSTGVSSSERGVATSICSSSSNQ
What is the function of this protein?
Sequence-specific DNA-binding transcription factor.  Binds to two specific DNA sites located in the promoter region of HOXA4.
What are the official names of this protein?
Early growth response protein 2b, EGR-2b, Protein krx-20, Zinc finger protein Krox-20.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SLRR_BACSU
Sequence: MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSVQFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNRLKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR
What is the function of this protein?
Represses sigma(D)-dependent flagellar genes and activate the eps and yqxM operons.  Repressor activity is regulated by SlrA.  Controls the initiation of biofilm formation.
What are the official names of this protein?
HTH-type transcriptional regulator SlrR.
Protein: MURB_TREDE
Sequence: MNNLFSILHNTPLFQEGTIEFYKPLKPLTSYKIGGPAEALFCPKDEDHLKEALIFLSKNKISASLIGGGTNILVSDKGFRGVLISLKNLNKIEIIGESENKVFVRAGAGVLTDKLTKWAVENSLSGLECFGGLPGSVGGAVFMNARCYDVSISDRLKSIKYILADGDKTEFAEYEYNPSDWDYKASPFQQNPVSTEITKNRKIVLSAVFTLTHGIKEEIAVKTEEKVQDRISKGHFKEPSAGSTFKNNRAFGLPSGKLIEDAGLKGLCEGGAQVAPWHGNFIINKHDASASDIKTLIEKVQKTVKDKTGFLLEPEVIFAGDWG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5010_ARATH
Sequence: MATRGAVAAAASTIWKHRRNPSLRSLSRHFNPNFNHRIIPTGFKYQVRAIQGTSTDPVITPLKNREEPKPQNWKIKMLYDGDCPLCMREVNMLMERNEKHGTIKFVDISSNDYSPEDNQGLDYKTVMGQIHAIQSDGNVVKGVEAFRRLYEEVGLGWVYTITKFEPIGKLADVVYDVWAKYRLQVTGRPSIEAILEARKKDKVETCGESKNCKI
What are the official names of this protein?
Uncharacterized protein At5g50100, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIPA_MYCBT
Sequence: MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYEQARNSRALASR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_PARMW
Sequence: MSELRDTRLEKCQALSDLGQGPYALNFEPTHRMAALHEAHADLPNGEEREVTVSVAGRVMTRRVMGKLAFFTLADETGTIQLFLEKAGLEAQQEGWFKQITGLVDGGDWLGVSGTLRRTDRGELSVKVSDWRMLTKALQPLPDKWHGLADVEKRYRQRYLDLIVSPDSRETFRRRARLVSGIRRWLDQRDFLEIETPVLQSEPGGADARPFETHHNALDLPLTLRIATELHLKRLVVGGFERVYELGRIFRNEGVSTRHNPEFTSVEIYQAYSDYIGMMELTEQMVSAVCQEVCGSCQITYQDTEIDLSPPWRRATMHELVEEATGLDFNSFSSREAAAVAMTGKGLHAPELADSVGRLLNEAFEQAVETTLIQPTFVTDYPVEISPLARPHRSKPGLVERFELFIVGREHANAFSELTDPVDQRQRLEAQQARKAAGDLEAQGLDEDFVTALEVGMPPTGGLGIGIDRLVMLLTDSPSIRDVIAFPLLRPEPRAADAPAMG
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUC1_HUMAN
Sequence: MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHSSVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL
What is the function of this protein?
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions.  Modulates signaling in ERK, SRC and NF-kappa-B pathways.  In activated T-cells, influences directly or indirectly the Ras/MAPK pathway.  Promotes tumor progression.  Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.  Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
What are the official names of this protein?
Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions. SUBCELLULAR LOCATION: [Isoform 5]: Secreted. SUBCELLULAR LOCATION: [Isoform Y]: Secreted. SUBCELLULAR LOCATION: [Isoform 9]: Secreted. SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.
Protein: UBR1_HUMAN
Sequence: MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRCPLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRVSEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIFFNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVRLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL
What is the function of this protein?
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.  Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.  May be involved in pancreatic homeostasis.  Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
What are the official names of this protein?
E3 ubiquitin-protein ligase UBR1, N-recognin-1, RING-type E3 ubiquitin transferase UBR1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I.
What is the protein family that this protein belongs to?
Belongs to the UBR1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: LEXA1_NOCFA
Sequence: MTDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSLEERGFLRRGEGVARPIDVRLFLHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLTLPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREANSGDIVAAMIGEEATVKVFRRRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SYR_HELHP
Sequence: MHHHIKALLQSALNIKNTIDIVLERPKNKDLGHFATPLALSLAKIEKTNPKLIAEEIAKILTNYAEFEKVETLNGFVNLTLSTTFLQHIAQKQLQHCMTLEADSINPNISQYTQKTQITPKEHILIEFVSANPTGPLHIGHARGAVYGDALTRVGRFLGYDILTEYYINDAGAQIYMLGLSIFLAGREHILKTQVEYPQSYYKGEYIIDLAKQCALHFGEDVFKSEDSISSLADFGKDMMLQEIKDNLAQVGIKFDSFVSEKSLYDRWQDTLDTLKSHQGIYTKDGKIWIASSQINDEKDRVVVRENGEPTYLAGDIIYHQDKFHRHFEHYINIWGADHHGYIARVKAAIHFLGYDENKLEVLLSQMVSLLKGGQPYKMSKRAGNFILMKDVIEDIGADALRFIFLSKKPDTHLEFDVDELKKEDGSNPIYYINYANARIHTLFNKAGVNMQQTAQNANKLDINEQAKALLFEALCLQQIIESSFRNREIQKICDYLKSLSASFHSFYNTHKILQSPNESSILYVLMIVSQSLTLGLSLLGIKAKTRM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANX1_MOUSE
Sequence: MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLSDEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQKTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQRLLNPSC
What is the function of this protein?
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation.  May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.  Plays a critical role in oogenesis.
What are the official names of this protein?
Pannexin-1.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CAS7_HALVD
Sequence: MTTLNRSELLFVYDAQDCNPNGNPIGDNRPRRDPDTGQGIITDVRLKRYLRDQLQDDGFDIYVKKTEGRSHTRTKLIKDVLGGVDDADDLEDLGDVAEAFLDAATDVRYFGSTLSFEASDKDEDEAFRDALNSSLPNNYQGPVQFLPSKSLNEVEENEEYDSLTSVISTGEGNRQGGFDLDDKRIKYGIFPFWGLVDNNGAESTNLSQADVERLDTLCWRALKNQTTSRSKLGQEPRLYVRVEYEEGNYHVGGLQNLLELGDDSSESLRSVKDVVVDVTELVETLERVADRIDTLHVVGDGRLELDIGDETIRADEFWSHLSEAGHDVHEIDVLNERDLA
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Plasmid targeted by CRISPR locus P1 transform wild-type cells very poorly (PubMed:22767603).  This protein helps process or stabilize pre-crRNA into individual crRNA units, in vivo Cas6 and Cas7 are also required for optimal crRNA processing and/or stability (PubMed:24459147).
What are the official names of this protein?
CRISPR-associated protein Cas7.
What are the subcellular locations of this protein?
Cytoplasm.