PharMolix/UniProtQA huggingface dataset:
Protein: PPARD_MOUSE
Sequence: MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY
What is the function of this protein?
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826).  Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid.  Once activated by a ligand, the receptor binds to promoter elements of target genes.  Regulates the peroxisomal beta-oxidation pathway of fatty acids.  Functions as transcription activator for the acyl-CoA oxidase gene.  Decreases expression of NPC1L1 once activated by a ligand (By similarity).
What are the official names of this protein?
Peroxisome proliferator-activated receptor delta, PPAR-delta, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMN_MYCSS
Sequence: MPNPLPLVFDAPRRAKPPRHFADLDATARAAAVAELGLPAFRAKQLATQYYGRLTADPQQMTDLPAAVREQVAEALFPDLLTAVREIETDAGETRKVLWRAVDGTTFESVLMRYSDRNTVCISSQAGCGMACPFCATGQGGLQRNLSTAEILEQVRAAAVELRDRDGEGIAPAARGGRLSNIVFMGMGEPLANYNRVIAAVRRIVAPPPDGFGISARSVTVSTVGLAPAIRKLADERLNVTLALSLHAPDDELRDTLVPVNNRWKVSEALDAARYYADVTGRRVSIEYALIRDVNDQPWRADLLGKRLHGALGPLVHVNVIPLNPTPGSEWDASPKPAEREFVRRVRERGVSCTVRDTRGREIAAACGQLAAEG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE6_HPV31
Sequence: MFKNPAERPRKLHELSSALEIPYDELRLNCVYCKGQLTETEVLDFAFTDLTIVYRDDTPHGVCTKCLRFYSKVSEFRWYRYSVYGTTLEKLTNKGICDLLIRCITCQRPLCPEEKQRHLDKKKRFHNIGGRWTGRCIACWRRPRTETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: FLAB_HELPJ
Sequence: MSFRINTNIAALTSHAVGVQNNRDLSSSLEKLSSGLRINKAADDSSGMAIADSLRSQSANLGQAIRNANDAIGMVQTADKAMDEQIKILDTIKTKAVQAAQDGQTLESRRALQSDIQRLLEELDNIANTTSFNGQQMLSGSFSNKEFQIGAYSNTTVKASIGSTSSDKIGHVRMETSSFSGEGMLASAAAQNLTEVGLNFKQVNGVNDYKIETVRISTSAGTGIGALSEIINRFSNTLGVRASYNVMATGGTPVQSGTVRELTINGVEIGTVNDVHKNDADGRLTNAINSVKDRTGVEASLDIQGRINLHSIDGRAISVHAASASGQVFGGGNFAGISGTQHAVIGRLTLTRTDARDIIVSGVNFSHVGFHSAQGVAEYTVNLRAVRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAMIVMDMADSARTQLDKIRSDMGSVQMELVTTINNISVTQVNVKAAESQIRDVDFAEESANFSKYNILAQSGSFAMAQANAVQQNVLRLLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  Important for motility and virulence.
What are the official names of this protein?
Flagellin B, Flagellin N.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: RF1_LEPBA
Sequence: MIDRLKKIQEKYLRIEDELAKATASDTLKNLSKERSRLTPVYTKADEYLKITKDCQDAKSLLESENDPDMHSMLKSEIEEGEKKLEELAKELEIMLLPPDPNSGKSILVEIRAGTGGEESGLFCADLFRMYNKYADKKGLRVEIIDMSQTGIGGYKEIVFSLDDDKAYDLFKFESGTHRVQRIPETESGGRIHTSAVTVAILPEAEEKEVEIKESDLRIDVYRSSGAGGQHVNTTDSAVRITHIPTGIVVASQEERSQIKNRDKAMRVLRARIADQAAETAKLSADALKKAQVGSGDRSERIRTYNFPQGRCTDHRIGFTSHNLPAIMEGDLDELIDALIQEDRSKRLAEAKA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBAC_OPHSE
Sequence: SLSDKDKTFVKAFWGKLKGKADDVGAEALARMFGAFPATKSYFAHWPDLSAGSGPVKKHGKIIMAGVGDAVDKIDNLVSGLSKLSDLHATKLRIDXXXXXXXXXXXLVTLAANFPADFTPELHVSLDKFFAAVGAALSDKYR
What is the function of this protein?
Involved in oxygen transport from the gills to various peripheral tissues.
What are the official names of this protein?
Hemoglobin cathodic subunit alpha, Hemoglobin cathodic alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RS11_BACFN
Sequence: MAKKTVAAKKRNVKVDANGQLHVHSSFNNIIVSLANSEGQIISWSSAGKMGFRGSKKNTPYAAQMAAQDCAKIAFDLGLRKVKAYVKGPGNGRESAIRTIHGAGIEVTEIIDVTPLPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: VHR1_YEAST
Sequence: MNGPPTFTQYRINKFSGNGATHKIRELLNFNDEKKWKQFSSRRLELIDKFQLSQYKASEQDQNIKQIATILRTEFGYPVSCSKEFEKLVTAAVQSVRRNRKRSKKRYALSIANGSGGNVNNSISSNSTSDDEISPSIYQRSNSDFLPSSNYAADFQFSNKFQPLMSHQSHNGTIFPTVGTQNDSSPSVTSTQQKYNDIVTMLVHDLVTNVVPLSEQALKDPYTGPNLSHFATSSLSQQPNITTNIPIDSTVPFFLREKLLLQIQRSRTCQDISQAAGSIDIYANLEILGEMSIRMSIAFVIERFFSNLVSSSMKYITAKTCSPENLALLSQRLFGAATRHNLSHFPAAQVQLRLLYLVIGGIVKDFGFDPTLYPLSEIIHHIVMVQYPLASSCASEPPSSSPNKRVKRSPPVVSSDVMLNNNNTLSNRATLLTTLPMKPQSANKDVNRRVIIRFNDREQAFTFHQLSNGPPTVSEVLENCKNLFNIINKNKNFGIFHNDNLLNDESLAKLFDSFSTSEIHLVIKDISTIPLQDAKIPVPITLPKMSCIGENPSMPSIPLVPQEKDDPKKSSLTAFDNILNRISKSPMNEENSNTTLNTGTSTSNTNNNDHNESVPAPYVTKNKNSFQNGNLPQPVFQPLL
What is the function of this protein?
Transcription factor that binds to the VHRE consensus sequence in promoters of VHT1 and BIO5, and regulates their biotin-dependent expression.
What are the official names of this protein?
Transcription factor VHR1, VHT1 regulator 1.
What is the protein family that this protein belongs to?
Belongs to the VHR1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GPR2_CAEEL
Sequence: MDVSYYDGPKDEVIEAMLKSAVTAMKLGQYEDGKGRLEDTMEFGTSNFQLLGTIYMYYGRVCRHLNHDAKALEFFEHELNMFKLIFNYPEACDSTRRIVQQALKMEKFSKARRFAEDLIDYTSNKKNGEKYIGQARILFASVCLEGCERDVESNQDEKKKLLSICAEQIAAVKLFNENNTEGAVSETKIMLIEAKCLSLDEKYEESRRKYQECIDFAIKTDQFEAVHIAYYDKALYAETYLLFFIIRDLRSALFYATKFGKERDVVKYKSKLSEEMLRNGEFHEAYLYGLEALVSIRKLGLNEHIGDVLLTIAKCLIALGKRRQAAYFIILGSVLTINQSSFKLFYEQIDVAMNQERSETATDQDACLAIDSSPDPTSSNDMINKFVVKLEHATNVETWEMIVNGIIEDQKKPVAIEKKENEEPVDMMDLIFSMSSRMDDQRTELSAARFIPPRPVSSASKKTTKSHRILPGLRANWTKVQSMKFDGHTMNRILKRSKKSKSSLDSTNSIQGDDTRSDDVTMTSK
What is the function of this protein?
In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135).  Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122).  Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122).
What are the official names of this protein?
G-protein regulator 2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle. Note=Located to the spindle and cell cortex when in complex with lin-5 and gpr-1 (PubMed:12730122). During early embryogenesis, cortical localization changes with the cell cycle. In one-cell embryo, uniform cortical localization from prophase to metaphase and posterior enrichment during anaphase. In the 2-cell embryo, uniform cortical localization in AB blastomere and posterior cortical enrichment in P1 blastomere during interphase. In P1, uniform cortical localization from prophase to early anaphase and then posterior cortical enrichment during late anaphase and telophase (PubMed:14534135, PubMed:12730122). Cortical localization and asymmetrical distribution is regulated by the csnk-1-mediated regulation of pkk-1 (PubMed:18694560). Enriched at the contact site between EMS and P2 from prophase to prometaphase (PubMed:14534135).
Protein: TOP1_RFVKA
Sequence: MRAFTYKDGKLYEDKELTIPVHCSNPTYEILKHVKIPSHLTDVIVYEQTYEQSLSRLIFVGLDSKGRRQYFYGKMHVQRRNSARDTIFIKVHRVIDKIHKFIDDTIEHKNDVLFQLGVFMLMETSFFIRMGKVKYLKENDTVGLLTLKNKNIVRENRKILIHFVGKDKIIHNFTVHSSNRLYKPLLRLIGRKEPDSFLFHKLSEKKVYKAVQQFGIRLKDLRTYGVNYTFLYNFWTNVKSLNPIPPIKKMISTSIKQTADIVGHTPSISKRAYIANTVLEYLTHDSELINTIRDISFDEFIRLITDYITNTQTV
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
Protein: SLE1_STAA3
Sequence: MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSNLIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNGLNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQKIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVFNRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNNDGSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
What is the function of this protein?
Peptidoglycan hydrolase involved in the splitting of the septum during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase sle1.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: TRUB_LACP3
Sequence: MNGILPLYKPTGMTSADAVYHARKILGIKKIGHSGTLDPNVDGVLPLAIGAGTKAVPQLMASGKVYTGEITLGFATTTEDLDGEVVDKTPLTQPFTADQLDAALTAWTGNITQIPPMFSAVKVNGRRLYEYARAGETVKRPERQATVSQFTRTDEPVFSATDGTQRFRFEVHVSKGTYIRTLAVDVGKTLGVAAVMSQLTRVKSGGFTLKQAVSIEQLKAHAAAGTLADVIQPIDIAFADLPQVDLTVEQFEAISHGRFLSLDQQTPRVRLHFAGVLKAIYRREDDQYRPDLMFLANEKNV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SYD_STRMK
Sequence: MRTHFCGLVDETLIGQTVTLAGWTDVARNQGGVCFIDLRDHEGIVQVTVEVDNAEVFAVAASLGYEDVLQVEGVVRARHAVNDKMRTGKVEVIATAITVLNKAAPLPFHAHENPGEETRLKYRYLDLRRPEMQRMQRTRIKLVQALRRHLDEKGFQDIETPILTKATPEGARDFLVPARMHPGEFYALPQSPQLFKQILMVAGFDRYYQIARCFRDEALRADRQLEFTQLDMEFAFVRERDVQDFVEDMIRAIFKEVVDVQLDASFPRMTWAEAMRRYGSDKPDLRIALELVDVAELVKDSEFPVFTGPANDAEGRVAALRIPGGASLSRKQIDEYAAHAAKYGAKGLAYIKIADNGEISSPIQKFFSEASFAALVAHVGAGNGDIVFFGAGGYNKVSDFMGALRLKAGKDFGLVADGWAPLWVTDFPMFEWDEEEQRYVALHHPFTAPAVDDIADLRANARTAVSRGYDMVLNGNEIGGGSIRIHRPDMQSAVFELLGIGAEEARAKFGFLLDALNYGAPPHGGIAFGIDRIAALMAGTESIRDVIPFPKTTGAQDLMTDAPSPIVDAQLAEVHIQVRPKTN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFH51_TRYCR
Sequence: MQARGTVKVQGDAKVDGKMSTGQHSHHQHLNSTQANATTTALEYRAMNRPLYRGPISHNIISEMAEGFYVLSGGYKKLFIPSKDVYALMQNVGMHLTEEEFHDALRVIGQSEPQNADELSFSDFLLLMTREVDDTMADELRSAFFHYDKYKTGYVTRKQFTELFATLGERSTPEELEELLAVAEVDETDDKIDYNRFVNELTSRVNCM
What are the official names of this protein?
EF-hand protein 5 variant 1, EFH5, Calmodulin-ubiquitin-associated protein CUB2.65.
Protein: TAM_ECO55
Sequence: MSDWNPSLYLHFAAERSRPAVELLARVPLENIEYVADLGCGPGNSTALLNQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPEQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGRESLAGIHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLAESEQQLFLTRYHQMLEEQYPLQENGQILLAFPRLFIVARRTE
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_CORJK
Sequence: MAGKLRVHELAKELGVTSKELLATLKEQGEFVKTASSTVQPPVVKKMKKHYGVGEESAKESATTPSPAAKPGPKPAAKAAPKAAAKPGPKPGPKPGPQPVKNTNPVAGAGTRPTSTVKPGEKPAPKPGAKPAPKTAAKPTPKPGAKPGPKPGGAKPGAKPGPKPGGRAPRVANNPFSSGAPAERPAPRPRGGQAGPGDMPRPGSRPGGAKKAGPKPGGAKQGGGRRPSPAMMPSHPNPAQMPSKSDNFGGGRGRGGRHGGPGGPGGPGGPGGPRGGRGGRRGGTAGAFGRPGGAPRKGRKSKRQKRNEYEAMQAPSVVGGVKLPNGKGAKIRLARGASLMDFAEKIKADAAALVQALFNLGEMVTATQSVSDETLMLLGEEMDYKVEVVSPEDEDRELLESFDLQFGEDEGEDEDLAQRPPVVTVMGHVDHGKTRLLDTIRKANVGSGEAGGITQHIGAYQVSVSMEGEDRLVTFLDTPGHEAFTAMRARGAKSTDIAILVVAADDGVMPQTVEAINHAKAADIPVVVAVNKIDKEGAQPDKIRGQLTEYGLIPEEYGGETMFVDISAKQGTNIDQLLESVLLTADASLDLRANPDMDAQGVAIEAHLDRGRGPVATIIVQRGTLRVGDSIVVGDAYGRVRRMIDEHGNDVQEAGPSRPVQVLGLTSVSGAGDNLLVVDEDRTARQIADRRDARRRNALAARSRKRVSLEDLDSVLKETNTLNLILKGDNAGTVEALEDALLKIEVDDEVDLNIIDRGVGAVTETNVNLAAASDAVIIGFNVRAEGKATEVANAEGVDIRYYSIIYKAIEEVEAALKGMLKPIYEEKQIGTAEIRQIFKASSVGLIAGCMVETGKVRRNAQARLVRDGNVVAEKTTIESLRREKDDVTEVSAGYECGMVLSYPDIQVDDIIEVFELVEVPRT
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUBR1_PSEAE
Sequence: MKKWQCVVCGLIYDEAKGWPEEGIEAGTRWEDVPEDWLCPDCGVGKLDFEMIEIG
What is the function of this protein?
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
What are the official names of this protein?
Rubredoxin-1, Rdxs.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXUA_BURL3
Sequence: MSFRWYGESDPVSLQYIRQIPGVTHIVSAIYDEPVGEVWPAHKIDALKATIERAGLQFEVVESVPVHEDIKLGKPGRDRLIDHYRQTIRHLGAAGVRVICYNFMPVFDWTRTELSKTLDDGSTCLAFSTDAVDRIDPDDGIALPGWDSSYQPEQLKALLAEYRDVDEAALWANLEYFLKAIIPVAEEAGVKMAIHPDDPPRPIFGLPRIVKNRDDLARIVRIVDTPANGLTLCSGSLGAGPQNDVEALVREFGAMGRIHFAHIRNVKVDANGDFEETAHLSSCGSLDIAAIVKAYHDTGFTGYVRPDHGRMIWGETGKPGYGLYDRALGAVYLNGLWEALAKFDRTPSLATQ
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: PLH15_FORAG
Sequence: MPRFLKYILGLFLISISAFGQNLVPEVTELESGFNSPPNQAKARTWWHWISGNVSKSGITKDLEAMKAVGIQEAQLFNVDLGFPAGPVDYLSEDWLDLFHFSALEAKRIGLELTFHNTAGWSSSGGPWISPEYAMQTVVYSEIIVKGGKAIKKQLPQPETKLNFYKDIAVLAFPKPKQTMKIDDLDFKSLSGRIRNHLLPDTKIIPSEAVIQKQEIINLTAHLNDAGILEWKVPKGEWVILRLGHTPTGKKNHPAPKGGHGLEVDKMSTKAVDVYWEGGIQPILNKLGDLVGTTVNNCLIDSYEVGTANWTAGFDAEFETLRGYSLVSYLPTLAGYYVESGEITERFLWDFRRTIGDLMAKNYYAHFRDLCHKNGLKFSVEPYWGPFDNMQVGATGDIVMCEFWSGGYPFFDSPKFVSSIAHLNGSSIVGAESFTGIGGWDEHPAELKSIGDRAWAEGITRFIFHTYVHQPWDVAPGLALSYHGTDFNRLNTWWRQGKAFMDYIARSQFMLQQGKNVADVLVFTGESSPNTAFLLPEIKQLGYDYDLIGSNKLSDLFVKNGKICTPVGGQYDVLMLPESDWIKPETLHKIEDLVKDGAKVIGSKPKKSPSLEHYSTCDAEVKRLSDFLWGKGLVKEISIVDFLKGNNLLADFKIESDDVSDISFIHRKTDEADIYFIANARKESREIKVRFRVSNKQPEIWQAESGTIKKPAVWQNHADGTTSLPLQLGMEEAVFVVFKNASKEKSQLVSAKMELENPKSEPLSNLQIIKAEYGTFLQEGLVDITDKVAAEVKDNQLHIQASRAFCDCDPAMGYIKEFRMEYQIGEDIKTISAQEKEYVNINAGDKKLTVLKAVFGKFKPETKGVPKHYPVHDVTEKIKQEIASGNLVIPVNNQLIGGKTPEGDNTTIKITFTTDGEEQTLFVPKGRPLNLSKDRSKPEIVLNDGETQWITPYPGTLSYKNLSGKVMATTVKSVPQPIMLAGTWDVEFPSDLVTINKVRFDELKSWSAVENEGIKYFSGTASYHKTFQVSKKLLKSNNKLELDLGSVAVIAEVILNGKPVGTLWKAPFRLDVTNDVKTGENKLEVKVTNLWPNRLIGDEKLPLDFERKGPKIKSVPDWLLNNTKRPSERTTFPAWKHWDKEDELLSSGLLGPVKINVLVEKSL
What is the function of this protein?
Glycoside hydrolase involved in ulvan degradation (Ref. 2).  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable).
What are the official names of this protein?
Putative beta-glucuronidase, Glycosyl hydrolase 2 family protein P15, P15_GH2, Polysaccharide utilization locus H protein P15, PUL H protein P15.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SUV92_MACFA
Sequence: MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKNNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.  H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.  SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length.  May participate in regulation of higher-order chromatin organization during spermatogenesis.  Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase SUV39H2, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: RPPH_FRATW
Sequence: MIDKSGYRANVAIVLLNKQNRVFWGQRRNRTSWQFPQGGVATGETPLQAMYRELHEEIGLRPQDVEVIASTRDWYKYDIPDSLVRTKEPICIGQKQKWFLLKLKSPESYIDLDANDSPEFDNWRWVSYWYPINHVVYFKQEVYRKALTYFKEYIA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: ECR_BOMMO
Sequence: MRVENVDNVSFALNGRADEWCMSVETRLDSLVREKSEVKAYVGGCPSVITDAGAYDALFDMRRRWSNNGGFPLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEYRALELWSYDDGITYNTAQSLLGACNMQQQQLQPQQPHPAPPTLPTMPLPMPPTTPKSENESMSSGREELSPASSINGCSADADARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVIQEPSKNKDRQRQKKDKGILLPVSTTTVEDHMPPIMQCDPPPPEAARIHEVVPRYLSEKLMEQNRQKNIPPLSANQKSLIARLVWYQEGYEQPSDEDLKRVTQTWQSDEEDEESDLPFRQITEMTILTVQLIVEFAKGLPGFSKISQSDQITLLKASSSEVMMLRVARRYDAASDSVLFANNKAYTRDNYRQGGMAYVIEDLLHFCRCMFAMGMDNVHFALLTAIVIFSDRPGLEQPSLVEEIQRYYLNTLRIYIINQNSASSRCAVIYGRILSVLTELRTLGTQNSNMCISLKLKNRKLPPFLEEIWDVAEVATTHPTVLPPTNPVVL
What is the function of this protein?
Receptor for ecdysone.  Binds to ecdysone response elements (ECRES).  May play a role in the implementation of the choriogenic program at the end of vitellogenesis.
What are the official names of this protein?
Ecdysone receptor, 20-hydroxy-ecdysone receptor, 20E receptor, EcRH, Ecdysteroid receptor, Nuclear receptor subfamily 1 group H member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.