PharMolix/UniProtQA huggingface dataset:
Protein: YRRS_BACSU
Sequence: MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSPSSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDSSSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATYDSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITWVDEKGWKPTKVEKLK
What are the official names of this protein?
Uncharacterized membrane protein YrrS.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TSAD_BART1
Sequence: MRLLGIETSCDETAAAVIEYNNESSSRILSNIVWSQIDHHAPYGGVVPEIAARAHVEILDHLILQALTEANTKLKDIDGIAATSGPGLIGGLLVGVMSAKALSLATGKPFIAVNHLEGHALTAVLTHNVKFPYLLLLVSGGHTQTILVHGVGNYQRLGTTIDDALGEAFDKTAKLLGLPYPGGPALEKAALLGDKNRIPLPRPLKGEKRLDFSFSGLKTAVRQAATAIAPLTENDVADIAASFQAAVTDTVRDRVHLALQHFTHQYPLSHDQEKHSPALVVAGGVAANQALRSTLQELAHQHGFEFIAPPLSLCTDNAAMIAFAGAQKLAQGETSSLDIAPRSRWPLDEKAIPLIGMGRRGTKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELH2_ACIAD
Sequence: MPVFHFKDTLTAQDVALNYATFGQADRPALIFSNSLGTNLSMWQQQIAYFQDKYFVICYDTRGHGASSTPVGPYRIDQLGTDVIALLDHLQIPQATFCGISMGGLTGQWLAIHFPERFNQVIVANTAAKIGEAQAWQARAQLVREQGLTPIAQTAATRWFTPGFIEDSPEIVEKLSHDLAQGSAEGYASCCEALAEADVRPQLQRISIPVLVIAGAQDPVTTVADGQFLCEHIVHSTLEVLEASHISNVEQPQAFNHAVEAVMKRFN
What are the official names of this protein?
3-oxoadipate enol-lactonase 2, 3-oxoadipate enol-lactonase II, Beta-ketoadipate enol-lactone hydrolase II, Enol-lactone hydrolase II.
Protein: RS13_MYCCT
Sequence: MARISGVEIPNNKRVVVSLTYIYGIGLPTAQSVLKTLNISEDIRVKDLTEEQIKNISIEISKYKTEGELRREVSLNIKRLMEIGSYRGLRHRKGLPVRGQSSKTNARTVKGPRKTVANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YFE5_CLOPA
Sequence: ILLDEHIRLLGIDPYSIDGYSRECFSHLAVASTVARGGADLAIGSEKMGLQVKNIDFIPLQKERYELVIKKEDMNKPFFKVLMDIINSNNFKMELEGLGGYDLSETGKIVTEL
What are the official names of this protein?
Uncharacterized protein in ferredoxin 2Fe-2S gene 5'region.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0886 C-terminal region.
Protein: CLPP_XANAC
Sequence: MSIVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDHMANVIVAQLLFLEADNPEKDISIYINSPGGVVTAGMAIYDTMQYIKPDVSTICVGQAASMGALLLASGAAGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILTLRSRLNEILAKHTGQSLETIARDTERDNFKSAVDAQAYGLVDQVLERRPEESIQPS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_SALPA
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVVTERDALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDAEEPQKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIRAKSPEIKIETLVPDFRGRMDRALDILNATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNAEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPEEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_PEDPA
Sequence: MNTVANADFNGIVMFERSHRENDLLVKFLTKEHGKRMFFIRNAKKVDFKLRSAILPFSHGQYTGLIRSNGLSYINAALDVQQFENIFQDITLNAYATFVLNLVDAAFDDNVKITSWFERINRALILIDAGNDAEIITDLIQIQLLNSFGISITWDHCVICGRTDLPLDYSEAFGGMLCQSHWERDEHRWHLKPKSARIIGILSAVSIFKLGQISISKETKQEIWNLTADIYKNQVGINLKSRSFIDQMKKWEI
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SYFA_CHLPN
Sequence: MEMKEEIEAVKQQFHSELDQVNSSQALADLKVRYLGKKGIFRSFSEKLKQCTDKAKLGSLINDFKTYVEDLLQEKSLVLLASEQAEAFSKEKIDSSLPGDSQPSGGRHILKSILDDVVDIFVHLGFCVREAPNIESEANNFTLLNFTEDHPARQMHDTFYLNATTVLRTHTSNVQARELKKQQPPIKVVAPGLCFRNEDISARSHVLFHQVEAFYVDHNVTFSDLTAILSAFYHSFFQRKTELRFRHSYFPFVEPGIEVDVSCECCGKGCALCKHTGWLEVAGAGMIHPQVLRNGNVDPEIYSGYAVGMGIERLAMLKYGVSDIRLFSENDLRFLQQFS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_RICFE
Sequence: MLLSKYFLPVLKEEPSEAQVTSHKLMLRSGMIRQQAAGIYTWLPLGLKVLKNIENIVRSNMNKAGALEVLMPCIQPAHLWMESGRFDNYGKEMLKFQDRHDNTLLFGPTNEDMITDIFRHNIKSYKDLPKNLYHIQWKFRDEIRPRFGVMRGREFLMKDAYSFDINEENAVKTYNQMYQAYINTFRDLGVFAIPVIADNGPIGGNLSHEFHIIAETGESTIYYNKRFKTLKDNPNIDVEEIKSWYAAAEEKHDVNKLPISEQEITSSKGIEVGHIFYIGSKYSVNMNALINDEHGKLTPVEMSSYGIGISRLVAAIIEANCNEKGIIWPSNVAPFKVSLINLNIHDSKCVELAAKVYKELSAQNIEVLYDDTEARAGSKFATHDLIGSPYQIIIGPKKAADDIVELKNRKIGVIEDIEVENLIHYIK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEFB_AEDAE
Sequence: MKSITVICFLALCTVAITSAYPQEPVLADEARPFANSLFDELPEETYQAAVENFRLKRATCDLLSGFGVGDSACAAHCIARGNRGGYCNSQKVCVCRN
What is the function of this protein?
Antibacterial peptide mostly active against Gram-positive bacteria.
What are the official names of this protein?
Defensin-B.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MCE1_ASHGO
Sequence: MDSRDAPEVPGIRQPANVTTDLKMIICKLLNSPKPAKTFPGSQPVSFQHVDIEEKLLAQDYYVCEKTDGLRALMLIIMNPVTKEQGCFLIDRENNYYLLNGFRFPRLPRANRKELLETLQDGTLVDGELVVQTNPATRLRELRYLMFDCLAINGRALVQSPTSSRLAHLGKEFYKPYYDLRAYYPDRCATFPFKLSMKHMNFSFDLDRVAGSLDKLPHVSDGLIFTAVDTPYTVGGKDSTLLKWKPEQENTVDFKMILEIPVVEDDTLPKKDRNRFYYNFDVKPSFHLYIWQGGPDVNTRLHDFEQPFSKKELEILHRTYKVFAELQISDEQWAKMKALEQPLNGRIVECAKDQETGEWKFLRFRDDKLNGNHVSVVQKVLESISDSVKLEDLEHMIPRIKARWEERKSKKRTHSSISGPMLPPVAETKAPREATQSRYIDDEDWSDEADDDDEDSLKRARIE
What is the function of this protein?
Second step of mRNA capping.  Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
What are the official names of this protein?
mRNA-capping enzyme subunit alpha, GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GTase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YKFO_ECOLI
Sequence: MSTTYQCIVR
What are the official names of this protein?
Protein YkfO.
Protein: YD023_YEAST
Sequence: MISVNFSPLISSSNTHICTIGAKTSGYPLQFSATTLAIVVPQLPDPITVTLKGFSAAFKETEEELLFLPAFKWPEVKFNLSAAADIFILSIFVFVEGGGVQYTIVS
What are the official names of this protein?
Putative uncharacterized protein YDL023C.
Protein: RDRP_I35A3
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKRKQKLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNGSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQRCCNLFEXFFPSSSYRRPVGISSMVEAMVSRAQIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: GLO2_SALTY
Sequence: MNLNSIPAFQDNYIWVLTNDEGRCVIVDPGEAAPVLKAIAEHKWMPEAIFLTHHHHDHVGGVKELLQHFPQMTVYGPAETQDKGATHLVGDGDTIRVLGEKFTLFATPGHTLGHVCYFSRPYLFCGDTLFSGGCGRLFEGTPSQMYQSLMKINSLPDDTLICCAHEYTLANIKFALSILPHDSFINEYYRKVKELRVKKQMTLPVILKNERKINLFLRTEDIDLINEINKETILQQPEARFAWLRSKKDTF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: IRC20_YEAST
Sequence: MSAVGALLAREYNVTAEKCDFFLENGSFDSVIAALPALNQEQETVTQKVSKNGKELINVASVNIEIPERISLSNNGRQLFKFIVDIEILPCENDNEATLVVSSDSVSLFQIGFKMENNSKIAVDKQLPLILDICAHKNQERALRNQLENRKSLERKPSRKRRKKNSNVNDPEKLLKSRIHELSLSYKDFECSPVVFRYNDSSLTWVLSFNLKLKFLNNKFNRFSVEANQILDLTFSNRDENEFERYHKHSHIHSNFIQKQFISQILEYSKDRLSKIKPFLPQSIPDLKVNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDEVGLIDFMNEYYAYGYELIARSPDEVGPSLLWNKLTGYILTTEDAAHLYNQYRKERLSGDYPVCAKGVLAEEMGLGKTIEILSLILLNRRKLKDSEATFIDDENRTITKTKTTLIICPNAILKQWLEEIELHANSLKWYTYRGYNEIMKDCKTVDEAVQQLCQYDIIVTSYNIIATEVHHAEFNRSIRSRRLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSAKCTSLLHRIHTWGVSGTPIQNIYNFRMIMSYLKLHPFCDEVDFIRTLQEEIKLRNEAKDYTSNDFVCQLKGVRFSIKDCMNIFYRYDLCIRHSKANVASQIHIPRQHNFIIPLEFAPIEWDNYLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYICCHALFPEILSTRQKRLHGHLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISNTPAKALESFIKIRDDLMIHIRQKFNVEDPFDKSLNLSEDEDEHMDERFGEKETSSGDESDREINGAKNHDNHNNDGMLSNHLKKKGLRAMMNLLHDCYFFLGSVYYNLGTRKLEEADDKHRKEKTEEVVYSDVFPKNELEEIEENRLLEQENYANAEILRKSILSSEARKVDMTIKMARTKFAPMTSNIPLRLINIEFDHKNDYSSNLAVSRCFKSLSKLIEGLNEQTKNFNELLDELLIIIYEPVHRTEDDDSTNKIIGNEEYSTSIDSQDKIFSLLGCLEIILQNRDNILTSESEVKIPKHLVPEGSIISKYQKQLLNSLRLISGTPLRTVFDELKNSRIVRRISSSNESESTIQNFEDYLLQYEVESKSLFKYNKQVRESLKILGSIYNAKTEYYSQLQRISDSLVSLHSLSAPQLSHLIRTINKSLGGTLDAKINNIESRLIYLKNLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSKCPICKGFCSISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEKLFGNKYEQFHQINEVHQIHIKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLKVIGKVLKLYHIEHLACLSNTANVGETINNFKRQPSVTCLLLNVKTLGAGLNLINAKHIFLLDPILNNSDELQAMGRNNRIGQDEETFVWNFMIRNTVEENILRYKCILEERKRKEKSKKGDKYDEAQDETDNEESDDAKFEISVVDQEVSNEHLWNCFFHGSD
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Uncharacterized ATP-dependent helicase IRC20, Increased recombination centers protein 20.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL2_BORRA
Sequence: MGIKIYRPKTSSLRYKTTLSFDELSKGNDPLKSLTKGKVSRAGRDSSGRISVRRRGGGHKRRYREIDFARRDKFGIPARVAAIEYDPNRSPNIALLVYRDGDKRYIIAPKGVKVGDILESGPNAPIKIGNALPLENIPVGKMVHNIELNIGKGGQLVRGAGGYAMIIASDGDYVTVKLPSGEMRMIFKKCIATLGEVGNEDYMNVSIGKAGKSRWLGRRPKVRGVAMNPIDHPHGGGEGKTSGGRHPVSPWGQPAKGYKTRKKNKYSDKFIVKRRNN
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: YIDD_HISS2
Sequence: METSHSFGAKVLIGAIRIYQLMISPLIGPRCRFVPTCSCYGIQAVKTHGVVKGSWLTVKRILKCHPFNVGGYDPVPPKINNNKENE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CHEA_SALTY
Sequence: MSMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTILQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPRDESKLRIVLSRLKANEVDLLEEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQEKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVITQSMLAQRSNELDPVNHGDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIEMPEKRLEAGKNVVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAEQVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEVFILPLNAVMESLQPREEDLHPLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVVILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQGLNREQRMAITAA
What is the function of this protein?
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.  CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
What are the official names of this protein?
Chemotaxis protein CheA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL7_HUMAN
Sequence: MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
What is the function of this protein?
Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:7527823, PubMed:25870237).  Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231).  Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963).
What are the official names of this protein?
Interleukin-7, IL-7.
What is the protein family that this protein belongs to?
Belongs to the IL-7/IL-9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_BORPD
Sequence: MDLKLLNDQGQAATFSAPDTIFGRDFNEALVHQVVVAYQANARSGNRAQKDRAEVKHTTKKPWRQKGTGRARAGMTSSPLWRGGGRTFPNSPEENFSQKVNKKMYRAGIRSILSQLAREDRIAVVDTFGLESPKTKLAVAKLKSLGLDSVLIITDAVDENVYLATRNLPHVAVVEPRYADPLSLIHYKKVLITKPAIAQLEEMLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: IBB3_SETIT
Sequence: SGERPWKCCDLQTCTKSIPAFCRCRDLLEQCSDACKECGKVRDSDPPRYICQDVYRGIPAPMCHEHE
What are the official names of this protein?
Bowman-Birk type trypsin inhibitor 3, Bowman-Birk type trypsin inhibitor III, FMTI-III.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: PGH1_SHEEP
Sequence: MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
What is the function of this protein?
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (PubMed:9448728).  The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes.  This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.  The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975).  Involved in the constitutive production of prostanoids in particular in the stomach and platelets.  In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.  In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (PubMed:10438452).  Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (PubMed:9448728).
What are the official names of this protein?
Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the prostaglandin G/H synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: NANT_ECOL5
Sequence: MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHGGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSTGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPIIGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNNLVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8E_IGNH4
Sequence: MGVYHGPDLKKITGGKKRRHRKVKRKYWMGRYPTNTTLAENEKRKIERVRGGNIKVRLRYAAYANVVDPNENVAKKVKILRVLETPANKELARHGIIVKGTKIETELGVAVVTSRPGQDGVINAVLIERK
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: AMD2_GIBM7
Sequence: MTTSKDTTKVHKPWTEVVTEKRALRDARIDKHLKSDIKFPSDGISFETVDIDVLTSLLRDRKVSAVEVIHAHSRACEAQKQTNCLTEICFDDALEQATQLDEFQQEHGQLMGPLHGVPVTVKDQFNIRGLDSTLGYVAKAFSPAESDAPLVQTLKKLGAVIIAKTNLPQSIMWCETNNPLWGLTTHPEDPKLTPGGSSGGEAAMLLMGASIIGWGTDIGGSIRIPCHMNGLWGLKPSSGRLSYRGVEVTLEGQQHIPSAVGPMARSLSCLKLVTKLAIEAEPWAIDPQLPPVPWRDGIFQATSTRPLSVFRDLVTKLEAAGHEVIEWDSSLNSSIIDIMDGYYSADGGEDIRSAVSAGGEPFIPQIQAFVNRGEPISVFEYWQLNKRKIAIQEAYHDMWDNKRSPTSRPVDVLLVPTMPHTAVPHGSCRWTGYTKIFNLLDYTALTFPAGKAPRGENDGSFWEHVPRNEVDAWNQRLYDPVTMGGRHVGLQIVGRRFEEEKVPIVLKPKCIF
What is the function of this protein?
Amidase; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases an other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
Amidase 2, Fusarium detoxification of benzoxazolinone cluster 2 protein AMD2, FDB2 cluster protein AMD2.
What is the protein family that this protein belongs to?
Belongs to the amidase family.