PharMolix/UniProtQA huggingface dataset:
Protein: DAPH_BACCZ
Sequence: MKMMDANEIISFIQKSEKKTPVKVYIKGDLKEVTFPETVQAFVNKKSGVLFGEWSEIKTILDENSKYIVDYVVENDRRNSAIPMLDLKGIKARIEPGAIIRDHVEIGDNAVIMMNATINIGAVIGEGSMIDMNAVLGGRATVGKNCHVGAGAVLAGVIEPPSAKPVIVEDDVVIGANVVVLEGVTVGKGAVVAAGAVVTEDVPPYTVVAGTPARVIKEIDEKTKAKTEIKQELRQLNPEK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: Y433_METJA
Sequence: MDAKEILELVEESYKSEDGDYKNKVYFISYFLSSLIFVLIHISIKYWNFNILFIVSLLLIIGSILIVRQQKLYKKTRCYFDKIFEKIVKYGMIAVVLSSVITLYTYPRISGVAIAGIFGFLLVIDGILFKSKKRKFLGLLMMFSSIPMFIFHEYQFLIFAFVQFLVALCFLICKE
What are the official names of this protein?
Uncharacterized protein MJ0433.
Protein: TMG2_MOUSE
Sequence: MRGRPSLLLVYMGLATCLDTSPHREQNQVLDIFLDAPEAQSFLVGRRRFPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYTYNGKGGRGRVDVAGLAVGLTSGILLIVLAGLGAFWYLHYRRRRLRGQESCLQETGLIIPLSPQTPQSPPLPPGLPTYEQALAASGVHDAPPPPYSSLRRPH
What are the official names of this protein?
Transmembrane gamma-carboxyglutamic acid protein 2, NEDD4 WW domain-binding protein 1, Proline-rich gamma-carboxyglutamic acid protein 2, Proline-rich Gla protein 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL15_SALTI
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL20_UREPA
Sequence: MRVKGGSVTRQRRKRWLEKAEGSWGTRNTSYRIARQTVIRAAEYAYRDRRNKKRDFRKLWISRINAAVRELGYTYSQFMNALVKANVVTKDGQGLNRKMLSELAINNPEAFNQLVDKVMK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PSBJ_SACHY
Sequence: MADTTGRIPLWLIGTVTGILVIGLIGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACPS_LEIXX
Sequence: MIAGIGVDVVDLARFGRSLARTPALRDRLFTEAERGLPVHSLAARFAAKEALIKALGGSEGVRWHDLEIVSDEERNPAFVLRNVVERQALERGIAHIHVSMSHDAGIATAFVVLERDS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_DESAH
Sequence: MGKIIGIDLGTTNSCVAVMEAGEPKVITNSEGNRTTPSVVALTEGGDRLVGQTAKRQAITNPENTVFGVKRLIGRKFDSPQIQGDKKVLPYKIEASANGDTRINLRGKQHSPAEISSFILANIKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGKIAGLTVKRIINEPTAASLAYGLDKKGEEKIVVFDLGGGTFDVSVLEIGDGVFEVKSTNGDTHLGGEDFDLRIIDYIADEFKKSQGIDIRGDKMALQRLKEAAEKAKMELSSAVETDINLPFITADASGPKHLDVKLTRAKLESLVADLLDNLVAPCKTALKDAGLTSSDINEVVLVGGMTRMPAVQERVEKIFSKKPHKGVNPDEVVAMGAAIQAGVLQGDVHDVLLLDVTPLSLGIETLGGVMTKLIDKNTTIPTKKSQVFSTAADSQPAVSIHVLQGEREMAAGNKTLGQFELTDLPPAPRGVPQIEVTFDIDANGIVHVAAKDKATGKEQSIRITAASGLSEEEIKKMVNDAELHADEDKKKHELVDAKNTAESLIHQTEKTLKEHGDKVDAATKTAIEAACEELKKVKEGTDAAIIKEKSEALTQASHKLAEAMYQQAAQESGQTEGAAQDPKGAAQDDDVVDADFEEVKDHKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NU4LM_PISOC
Sequence: MSSYLTIIISFFYLGILGILLNRLHLLSILLCFELLLISLFIWICNTLFKTFNNLILSNNLILLTLSACEASAGLSLMVALSRTHNSDLVSSMNILQQ
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: DEF_CELJU
Sequence: MALLPILEFPDPRLRTVAKPVTQVDDSIRQLVDDMFETMYDAPGIGLAATQVNVHKRVVVIDVSEDKSQPLVFINPEIEVLDEELSQYDEGCLSVPGFYETVERPGHIRVKALDRAGNAFELQPQGLLAVCIQHELDHLNGKLFVDHISPFKRSRIRSKLEKKHKAGVR
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: TM242_PONAB
Sequence: METAGAGTGQPASGLEAPGSADDRLFLVKGGIFLGTVAAAGMLAGFITTLSLAKKKSPEWFNKGSMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHSMKDFRSKMQSIFPTIPKNSESAVEWEETLKSK
What is the function of this protein?
Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3.  Participates in the incorporation of the c-ring into vestigial complexes.  Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.
What are the official names of this protein?
Transmembrane protein 242.
What is the protein family that this protein belongs to?
Belongs to the TMEM242 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FABZ_CALS8
Sequence: MYDVTSILQILPHRYPFLLVDRIIEIEEGKKAKGIKNVTINEPFFQGHFPGNPVMPGVLIVEAMAQVGAVAILSKEEFKGKTPFFAGIDKVRFKKVVRPGDVLLIETELISLKGYIGKAKATAYVEGEVVCEGELLFAIK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4061_PHOLL
Sequence: MAKQPEDWLNDYPAEEEEEEIIWVSKSEIKRDAEALKKLGTELVELSKSALERVPLDEDLLAAIELAQKIKREGRRRQLQFIGKLLRTRDVEPITIALDKLKNRHNQQITLLHKLEELRDKLIDGNDDVIDEVVALFPQTDRQQLRTLIRNAKKEKAANKPPKSYRQIFQYLKDMAESA
What are the official names of this protein?
UPF0307 protein plu4061.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: RECR_RICAE
Sequence: MNETNDNDIDQLIYLFSKLPGLGIRSARRIALYLLQDKDVRLKSLINNLVEIDKKIVKCEICGNMDTENMCRICSSEYRDKSIIAIVETVAELWAMERSGNFKGLYHVLGHNLSAASRQNPSILRLPELLTRCFAENIKEVIIATNSTLEGQTTAYFITEYLKEHPAKISRLASGIPIGGELDYLDEGTVSAAINLRQPFE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: INS2A_CONGE
Sequence: MTTSSYFLLVALGLLLYVRQSFSTHEHTCQLDDPAHPQGKCGSDLVNYHEEKCEEEEARRGGTNDGGKKRRRASPLWKRRRFLSMLKARAKRTGYKGIACECCQHYCTDQEFINYCPPVTESSSSSSSAA
What is the function of this protein?
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock.  Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin.  In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
What are the official names of this protein?
Con-Ins G2, Insulin 2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEP10_SCHMA
Sequence: MTADVLKALPPDVRTLKLSGHVGFDSLPDQLVNKAISQGFVFNILCVGETGIGKSTLLETLFNQKFDFSPSNHDLTDPKLKAVTYDLKEANVKLKLTVVETCGYGDQINKENNIKPVVDYIDNQFENYLQEELKMKRSMQAFHDTRVHVCLYFIAPTGHSLKSIDLVAMKKLENKVNVIPVIAKSDTITKSELQKFKARILSEIQSNEIGIYQFPTDDEAVSETNSVMNQHIPFAVVGSSEEVKINGKTVRVRQYPWGSVQVENENHCDFVRLREMLLRVNMEDLRERTHGVHYETYRRQRLIEMGFRDDEKMSLQETYEKRRELQRKELQQKEEEMRQMFVQRVKEKEQVLKEAERELQTKFESLKKTHAEEKKKLEEKKRFLEEEIAAFERRKQLAEQARQGNLTMKKRK
What is the function of this protein?
Filament-forming GTP-binding protein.  Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins.  May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability (PubMed:24464615).  Able to bind to phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes.  Self-assembles into ordered cage-like structures on the vesicle membrane.  Binds also to 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS)-containing vesicles suggesting the requirement for negatively charged membranes.  Is also able to promote deformation of the GUVs (PubMed:27687162).
What are the official names of this protein?
Septin-10, SmSEPT10.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with actin in the longitudinal and circular muscles of the sporocyst.
Protein: PTR1A_XENLA
Sequence: MAEWKEEVEVLVQRVVKDITGAFRRNPNIDEIGLIPCPEAKYNRSPIVLVENKLGVESWCIKFLLPYVHNKLLLYRQKKLWLNRDELIDVTCTLLLLNPDFTTAWNVRKELIQSGTLNPVKDLQLGKLALTKFPKSPETWIHRRWALQRLVQELVVAAVVDKDAICPETSERIQAIVEEEMHVCCEAAGRYPSNYNSWSHRIWVVQHLGNLKATLLIDELSSTKHWVSMHVSDHSGFHYRQFLLKSLLSKTLKDFDNVGAITDLIANEENLCLPRDGEANWNQICFDLPYLLEEEMDLNRELVDSFPGHETLWCHRRQIFNLIHQLLLEQSQSATPQSTSASIPDGSGNISQMSTTFQSYVTNPMDIDGMSDPNKQGYTQEIKRLKRAPVQDSLSFDSELRFINCVLTNCCSPEQSRFAASYRKWLLSLQGH
What are the official names of this protein?
Protein prenyltransferase alpha subunit repeat-containing protein 1-A.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit alpha family.
Protein: HPRK_NEIG2
Sequence: MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANDLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: IABG_MAIZE
Sequence: MAPHVLVVPFPGQGHMNPMVQFAKRLASKGVATTLVTTRFIQRTADVDAHPAMVEAISDGHDEGGFASAAGVAEYLEKQAAAASASLASLVEARASSADAFTCVVYDSYEDWVLPVARRMGLPAVPFSTQSCAVSAVYYHFSQGRLAVPPGAAADGSDGGAGAAALSEAFLGLPEMERSELPSFVFDHGPYPTIAMQAIKQFAHAGKDDWVLFNSFEELETEVLAGLTKYLKARAIGPCVPLPTAGRTAGANGRITYGANLVKPEDACTKWLDTKPDRSVAYVSFGSLASLGNAQKEELARGLLAAGKPFLWVVRASDEHQVPRYLLAEATATGAAMVVPWCPQLDVLAHPAVGCFVTHCGWNSTLEALSFGVPMVAMALWTDQPTNARNVELAWGAGVRARRDAGAGVFLRGEVERCVRAVMDGGEAASAARKAAGEWRDRARAAVAPGGSSDRNLDEFVQFVRAGATEK
What are the official names of this protein?
Indole-3-acetate beta-glucosyltransferase, (Uridine 5'-diphosphate-glucose:indol-3-ylacetyl)-beta-D-glucosyl transferase, IAA-Glu synthase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: GCSPB_KOSOT
Sequence: MTIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRKNYSVDNGFYPLGSCTMKYNPKLNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSEITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKVIVPDSAHGTNPASASMAGFQVVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYDGANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDLTDEGYILKTDLSHSIGRIRSFYGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTRLSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRMLDYGVHPPTIYFPLIVHEALMIEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIPKEQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: GSID_SALCH
Sequence: MRLFNWRRQAILHAMPVVKPDQIRTPWREFWRRFRRQHVALVAGGFVLALILVAIFARWLTPYDAENYFDYDSLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGAIIGTVLGLLAGYYEGWWDRFIMRICDVLFAFPGILLAIAVVAVLGSGIANVIVAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDTTILFSHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVALFPAVAIFLTVLAFNLLGDGLRDALDPKIKG
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutathione transport system permease protein GsiD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOAA_EDWI9
Sequence: MVSQLTDAFARTFYYLRLSVTDVCNFRCTYCLPGGYRPDSHGAKRFLSCDEIRRISHAFAALGTEKVRLTGGEPTLRRDFCDIVAAVRENSAIRTLAVTTNGYRMARDVGAWRDAGLTAINVSVDSLDARQFHAITGEDRFAQVMAGIDAAFDAGFGRIKVNTVLMRGVNDGSLQAFLHWIRRRPIQMRFIELMETGDGSELFRRHHVSGATIRTQLLAAGWQRRLPGRSDGPAQVFWHPDYLGEVGLIMPYEKNFCASCNRLRVSAVGNLHLCLFGEQGIALRDLLQEDAQQAALQVRIAAALRHKREGHFLHQGDSGHTQNLSFIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: CLPP1_SYNE7
Sequence: MIPIVVEESGRGERAFDIYSRLLRERIIFLGEPVTSDVANRIVAQLLFLEAEDPEKDIYLYINSPGGSVYDGLGIFDTMNHIRPDVSTVCVGLAASMGAFLLAAGAKGKRTSLAHSRIMIHQPLGGAQGQAKDIEIQANEILYIKQNLNEVLAERTGQPLSRIEDDTDRDFFMSASEAVEYGLIDRVIDRRALKATA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB14_CHICK
Sequence: MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
What is the function of this protein?
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.  Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity).
What are the official names of this protein?
Ras-related protein Rab-14.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome.
Protein: INT3_DROMO
Sequence: MEQQQQKSAVHVSKLFVCTAVDCKDEIEEKFERSYASLQQQIAGLSDKEMHDMLTQFVCKEKQHEEISIGFLYIILTDPAMAPKTYRDITLVSRDGMNVIVANLTLLVAEKYTKLTETARRQLIWVLREFVKHQVLSVENVIWNCLRQAGGGDVSHKNLFLVESLLDIFIEYRAWLETNPFLVQSSVYSFVRLIEDHANPALISLRQKEVKFTISLIRDRFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILYNPKSLHPTFNGIWHLLQIRTSRRFLQCRLLPEMERKLHFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIRNHPFVSSTLLDFLCRITKNFYIKNEDKIRLGVYNSLKLILDKQVIPNLHPLFESPKLDRELRNLIRENFREFVSPVSNMPQTMYPATHSIQAPIFKKEADQRITQIENIDVGAGVLAANSSTISLVDDDSKVATIPTESLERETEAVFSDEDGENLGRCTKNEENTDDDDDLPLSKVRLKEKPVPEKVELPEAIAESFEIFVTKRNSFTWEAFLKDFRTLPASTLDETQLNYVISNTVLILRETLPQQNVFSESKTEEKCLAKSISYPLYGLFRFLYENEDKSKKPFQSLLSEICERLSETGYLLLYFMKIHCKLQTRKNAQQSYQFKTTVYRQICEATDGKIASCLVRDLDLLEKENTTIYLWLLPDIYREFKTIAINNTDLLRITLRCVDAKNVRDIMYSIAQGKMTIFKQDGLIECIRESLEYETYEQFCLWQLIQAHDVPLKCIQDILPELEAANHPEALSHLLLLLKNEEPTNEIIRLLLSREAKSRGDPFVTSALRFWCQRCEEKLSEIIASLLTSKYPSSSPNKRKRPSKGSSAASSTPSADHVLNHLEHYRRSCRHGTGTGLYVHDMMQRALQSAYTHSNESTKKQFSDLFALAAEDETTAVGRRGGSGRGRKQPAGKKDSNNHSAGSKKNSDVVKAIYSSDESSSEEDWSKHKITQAAKKRKKAINDSD
What are the official names of this protein?
Integrator complex subunit 3 homolog, SOSS complex subunit A homolog.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 3 family.
Protein: KSR2_MOUSE
Sequence: MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCAASNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPDQLSLEDLLEMTDEQVCETVEKYGANQEECARLNASLSCLRNVHKSGGNLSKQDWIIQWPTTEPGQESNPVCPPEPSPWIRTHLSQSPRVQTKCPQHFCPTSPTPGTPVYTQVDRLTVDAYPNLCPPPPPLESGHRSLPPSPRQRHVVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGNRVDEANTPKAKKKSKPLNLKIHSGVGSCENIPAQQRSPLLSERSLRSFFVGHGPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPVRKPARYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCPRQKKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNTILEGNPLLQIEVEPTSENEESHNEAEESEDEFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
What is the function of this protein?
Location-regulated scaffold connecting MEK to RAF.  Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro).  Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1.  Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro).  Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling.  Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
What are the official names of this protein?
Kinase suppressor of Ras 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: IF1_MYCSJ
Sequence: MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX26_YEAST
Sequence: MFFSQVLRSSARAAPIKRYTGGRIGESWVITEGRRLIPEIFQWSAVLSVCLGWPGAVYFFSKARKA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 26, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the fungal cytochrome c oxidase subunit 26 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.