PharMolix/UniProtQA huggingface dataset:
Protein: HEMY_HAEIN
Sequence: MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEWGVTRFFRLSRSSYQWFSNRKRVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLNLIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIARTRILLQQNKLPAARSSVDSLLEMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKMNEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAISLPLCTQITRLQPEDNSKLLKLIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKNVIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSVMAIQDVIPESAEEKTEENSTALLESKSE
What is the function of this protein?
Involved in a late step of protoheme IX synthesis.
What are the official names of this protein?
Protein HemY homolog.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: A1KA1_LOXAP
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDSSANPEYTYHGVPCDCGGTCTKWEHFNEFLKGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQASDAGKKLAKSLLQNYWNNGNNGGRAYIVLSIPNLAHYKLITGFKEALTSEGHPELMDKVGYDFSGNDDIGDVANAYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSSGYINKVYYWTVDKRQSTRDALDAGVDGIMTNYPDVIADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LapSicTox-alphaIB1ai, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UGT52_DICDI
Sequence: MDEFTSDSLTTSRLLRQISHSDSLSSVGSSSNRSNSNYENKINNGIINDFDSTNANDGISNNSNNSNNNNNSSSILKIHQSPQSILSTEQQHQIQQYQQYHQQQIYESGYVPPHVYIFDPDYKSNNDEEDKEKRSLIELNKSTDLSNIKTTTTTTTTTTPPPLMIPENEEENKQLRQEILNELSKSESFTKIKEPGEIYGFCECSLLYNHLTCANLVITSNYLIFLPQQQVDSDYVLENYLYKKGDFFWKKYWFVLTPDSISWYKSSILKETHYPNGTILLSKIVTVDKLDPEETGKPFCLQIMTNTSIHLIQLDTEPQLEHWYHEINRMQKNLNVTIPIGDIVSITMESNAALFFDSLCLTLKKGENCLVTPSSSSNEVYSLLIKLWNRNRGVTVVEPEKQQRLLEFQKTFKLSQGVNLLIETPCVFYQDEEFSYEGVLYATTEGTLYFSSLDSVLIIPESDIYAITIDRKSDNRDALKVYTTDYDVLFFDSIDDIETFFNVISTSLARSNPKIFFSTVGQIPPIDEPKHDEKEHKSTYQTISSGIRSWKIPIPSLPNFSIPIPKSIPIPLFRSKSSSHLDPQNSQQQQQQQQQSSSLQLDDNNNNIVIPHTSNPTTIIPSTSSSSAIPPPPSSTSSTSSTTHEKTIIIQKNSSINSTFHDIFPLLPLDETVIMFQNCSLYYYSYDSNVEGIVYITKSYIAFNPSPLDKQQQQQQQQQQQQPNSSSITSTTYDRDLDTDSDTDSESDFDYPKQSQHDNSVVMVNNNQYKVKEVLMKKALIPIEDIVSVTKERFLLFFNQCVKIITLDHKWIFGSLNNINSFYNLILETWKQIPKTLLDSSSSSSSSSSSSLLSSSPNNNNSDLNINGNSEGSIFTPLESIKIKNKLGLPADEVLITWFNCTNFKGAQLKYGFLYISNNNICFRSKFGFQKRTIVIPLSQVIEIKKYSAFIPNGIKITTASHHEFQFASFIHRNRVYQILYETWLKANNKKSNSSNSLSSSPTITSPLAISPSIASPSITPPSSTPPSSTTPSSTTPTITSPTIHSTLPSTVVYNDIQEIIDGENNSNNNNNNNNTNNTNKSNSFIGNVEEDVDKIKRSIKSLPILKIHSAQQQQQQQPKTTTTTTSTTTTNLISPRLLTPLTITQSPGFSSLVNSPILPVKPLRITILTIGSRGDIQPFIALSLGLKEYGHNVTLATHELYRDLISKEFGLNYQPLGGDPRELMDLCVRNGIFTPKFIKEALSRFRSFIDDLLLTCWKAVQNSNTQVLIATPGCFAGPHIGEVLQIPFFNAFTMPFTRTRTYPNPFAPFASHQMGGVFNLATHVMMEKVLWQPISGQINQWRTETLKIPPWNSSVSINETYRMPYLYCFSKYLVPKPPDWSGEIAITGYWTLKNQANSDSPPDDLIQFLNEESSTENDDIPIYIGFGSIVIDNPTALSLLLIEAIKLSGKRAIISQGWGGLSIDEHNNNNNNNNNNNNGENSDSNKSSLQSNRIYLLKKPVDHSWLFEKVSLVISHGGAGTVAASLLAAKPTIVVPFFGDQFFWGERIKQTGIGTSIPFDILTAKSLSSHIISILNEPSVRAKVNKMSHLLKREDGVKTAIDFIHRYLPFSFIPPREIPFSSAPNSCMGCKQPFTLLHVMKARVHCHCCGKIFCESCTSHKCPIKKYRINTPVRVCDKCFNDLQSNPSSNSFILND
What is the function of this protein?
Involved in the biosynthesis of sterol glucoside.  Can use different sterols such as cholesterol, sitosterol, and ergosterol as sugar acceptors.
What are the official names of this protein?
UDP-sugar-dependent glycosyltransferase 52, Sterol 3-beta-glucosyltransferase, UDP-glycosyltransferase 52.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
Protein: INHA_TABYA
Sequence: MTLKRIFCAALALIVLQSVASAVDYCRLSCPEGRDHVGCRNAGFGAHCGSNPQTPKLHQEHIKMVLQKTNWLRGVVAEGSFCYPKAARMPVLVWDDELANLAALHTKGCVTETNKCRSTERFHSPGQSSYEISGDTLPSAMDILNFALRDWYLQKDNLTREDIGSYPAGEDKGLKNMANLISDKVTAIGCGLAQWRKENYKGAFHCSLLFIERSRSSIYQRGDNFATNCLKTHPTYRAGVLSDEQYSN
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (By similarity).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (By similarity).
What are the official names of this protein?
Tabinhibitin 10.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y019_BACCN
Sequence: MMRGGMGNMNNMMKQMQKMQKQMAKAQEELGEKQVEGTAGGGMVTVIANGHKQILDVKMKEEVVDPEDIEMLQDLVLAATNDALKKAEELSNATMGQFTKGLNLPGGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Bcer98_0019.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RIMO_PROMH
Sequence: MSQTNQVPKIGFVSLGCPKNLVDSERILTELRTEGYQVVPTYDDADLVIVNTCGFIDSAVQESLEAIGEALDENGKVIVTGCLGAKENQIREVHPKVLEITGPHSYEQVLSHIHHYVPKPSHNPFTSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLDSRPIGEVLNEAKRLVNAGVKELLVISQDTSAYGVDTKHQTGFWDGMPVKTSMVSLCEQLAKLGIWVRLHYVYPYPHVDEVIPLMAEGKILPYLDIPLQHASPKVLKLMKRPGSVERTLERVKRWREICPELTLRSTFIVGFPGETEEDFQMLLDFLTEARLDRVGCFKYSPVEGAKANELPDQVPEEVKEERYHRFMQLQQQISTERLQEKIGKVLPVIIDEVDEEGAIGRSMADAPEIDGAVYLNEQFDVEPGQIVRVLIEHADEYDLWGTIVEQ
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMT1_MAIZE
Sequence: MGSTAGDVAAVVDEEACMYAMQLASSSILPMTLKNAIELGLLEVLQKEAGGGKAALAPEEVVARMPAAPGDPAAAAAMVDRMLRLLASYDVVRCQMEDRDGRYERRYSAAPVCKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDSRFNRVFNEGMKNHSVIITKKLLDFYTGFEGVSTLVDVGGGVGATLHAITSRHPHISGVNFDLPHVISEAPPFPGVRHVGGDMFASVPAGDAILMKWILHDWSDAHCATLLKNCYDALPENGKVIVVECVLPVNTEATPKAQGVFHVDMIMLAHNPGGKERYEREFRELAKGAGFSGFKATYIYANAWAIEFIK
What is the function of this protein?
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid (By similarity).  The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins (PubMed:16941210).  Can use the flavone tricetin (5,7,3',4',5'-pentahydroxyflavone) as the preferred substrate and give rise to its 3',5'-dimethyl derivative, tricin (3',5'-dimethoxy-5,7,4'-trihydroxyflavone), as the major product, and selgin to a lower extent (Ref. 3).  Tricin exhibits potential benefits for human health including relaxant effect on smooth muscle of intestinal tissues, antioxidant effect, antihistaminic activity, and growth inhibition of human malignant breast tumor cells and colon cancer cells (Ref. 3).  Can also use luteolin, quercetin and 5-hydroxyferulic acid (5HF) as substrates (Ref. 3).
What are the official names of this protein?
Caffeic acid 3-O-methyltransferase, CAOMT, COMT, Flavone 3'-O-methyltransferase 1, ZmOMT1, S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase, Tricin synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: PER1_BETPN
Sequence: GLTQKDLVALSGAHTIGKAR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLPK_SHEWM
Sequence: MTKKYVVALDQGTTSSRAIIFDHDANIVSVSQREFTQIYPQAGWVEHDPMEIWASQSSTLIEVIARSGIHASEIASIGITNQRETTVIWDKQTGKPVYNAIVWQCRRSSEICEELKSQGLEAYIRDTTGLLLDPYFSGTKIKWILDNVSGVRERAERGELLFGTIDTWLVWKLTEGKVHVTDPTNASRTLLFNIHTQSWDKRILEALTIPESLLPQVKPSSAVYGKTRIAGEGGEISIAGIAGDQQSALFGQLCTEPGMAKNTYGTGCFLLMNTGEKAVKSNHGLLTTIAIGAKGEVNYALEGSVFMGGATIQWLRDELGLIRDAQDTEYFASRVESTNGVYLVPAFVGLGAPYWDPSARGALVGLTRGSNRNHIIRAALEAIAYQSRDLLDAMAKDSGVELKKLKVDGGAVANDFLMQFQADITSVEVQRPAVTETTAMGAAFLAGLAVGFWDSTSELKHRADIDKSFMPSISEEQKDELYAGWQKAVSQTING
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: YUGM_BACSU
Sequence: MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHFFIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAVYFLIECAFFPVGRAKETTISM
What are the official names of this protein?
Uncharacterized protein YugM.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLYA_LEGPC
Sequence: MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAISRAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALEKLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLILCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLLVDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNISRVKTQVLLLCREFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYT4_ARATH
Sequence: MADLTCTTPFLLYPSLVIILFFYSINHHNQIFSSVVDDDPSCRLSSSPQAVFSSFRIFPFRSSSSCLNITSNNNSTSEVVVVEEVDEAVERIEEGLAMARAAIRKAGEKNLRRDRDRTNNSDVGVVSNGSVYLNAFTFHQSHKEMEKRFKIWTYREGEAPLFHKGPLNNIYAIEGQFMDEIENGNSRFKAASPEEATVFYIPVGIVNIIRFVYRPYTSYARDRLQNIVKDYISLISNRYPYWNRSRGADHFFLSCHDWAPDVSAVDPELYKHFIRALCNANSSEGFTPMRDVSLPEINIPHSQLGFVHTGEPPQNRKLLAFFAGGSHGDVRKILFQHWKEKDKDVLVYENLPKTMNYTKMMDKAKFCLCPSGWEVASPRIVESLYSGCVPVIIADYYVLPFSDVLNWKTFSVHIPISKMPDIKKILEAITEEEYLNMQRRVLEVRKHFVINRPSKPYDMLHMIMHSIWLRRLNVRIPLSQ
What is the function of this protein?
May be involved in cell wall biosynthesis.
What are the official names of this protein?
Probable glycosyltransferase At5g11130.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: NCP_PIG
Sequence: GPANXIPIVSRREWGALASEXSANL
What are the official names of this protein?
20 kDa neutrophil cationic protein, NCP.
Protein: DRM2_ARATH
Sequence: MVIWNNDDDDFLEIDNFQSSPRSSPIHAMQCRVENLAGVAVTTSSLSSPTETTDLVQMGFSDEVFATLFDMGFPVEMISRAIKETGPNVETSVIIDTISKYSSDCEAGSSKSKAIDHFLAMGFDEEKVVKAIQEHGEDNMEAIANALLSCPEAKKLPAAVEEEDGIDWSSSDDDTNYTDMLNSDDEKDPNSNENGSKIRSLVKMGFSELEASLAVERCGENVDIAELTDFLCAAQMAREFSEFYTEHEEQKPRHNIKKRRFESKGEPRSSVDDEPIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWETISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDAFPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKHVQRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTERFKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIKMKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEKYGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMRGS
What is the function of this protein?
Involved in de novo DNA methylation.  Controls asymmetric and CpNpG methylation.  Required for FWA gene silencing but not for the maintenance of SUP gene silencing.  Functionally redundant to CMT3 to maintain non-CpG methylation.  Involved in RNA-directed DNA methylation (RdDM) (PubMed:12121623, PubMed:12151602, PubMed:14680640).  Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts (PubMed:21060858, PubMed:21212233).  Associates with long non-coding RNA (lncRNA) produced by RNA polymerase V (Pol V).  This association is dependent on AGO4 and IDN2, and results in DNA methylation of RdDM target loci (PubMed:24862207).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase DRM2, Protein DOMAINS REARRANGED METHYLASE 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Peri-nucleolar.
Protein: RL13_RUTMC
Sequence: MKTFSAKAHEVKRDWLLVDADGKILGRFATQIASRLRGKHKPEYTPHTDTGDYIVIINASKIKVTGNKFEDKMYHHHTGYVGNLKSIAFKDLQAKKPEEIINKVVKGMLPKGPLGRDMFRKMKVFAGSEHTHGAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: TPIS_SHESW
Sequence: MALRRPMVAGNWKMNGSAALAQELFKKFASKLQNDSAEVVLCPPSIYLESVRQLLEANKEALDGSLVRMGAQNLSQHDFGAYTGEVSGQMLKDSGCRYVIIGHSERRRMYGETSNIVAEKFAAAQKHGLTPILCVGESGPAREARRTFEVIAEELDIVIQKNGTMAFDNAIIAYEPLWAVGTGKSATPEQAQEVHAFIRKRLSEVSPFIGENIRILYGGSVTPSNAADLFAQPDVDGGLIGGASLNSSEFLSLCTIAMSA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_OENOB
Sequence: MRTIKIIQTASQLPEKIVSNDDLAGMMDTSDEWIRSRTGIFKRHIAVDETTASLAASVLQKLLKGSGISADQIDFVLVATMSPDSMAPSTAAQASALAGLSNAFAMDINVACSGFVYGLTLAHGLVNTLGSHYGVVIGAETLSKLVDWQERSTAVLFGDGAAGVLVEAVDGPERLLAADLKTFGKEAKSLTAGHLWSSTTWNQPEKGSRYFQMDGHAVYSFATRQVAASIKRTFEKISADIGDTDYFLLHQANQRIIDKVADLLKQPADRFLSNLSKYGNTSAASIPLLLDEMVTGNIVKSGQLLTLSGFGAGLSVGSIVYKY
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F162A_HUMAN
Sequence: MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE
What is the function of this protein?
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785).  May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785).  May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).
What are the official names of this protein?
Protein FAM162A, E2-induced gene 5 protein, Growth and transformation-dependent protein, HGTD-P.
What is the protein family that this protein belongs to?
Belongs to the UPF0389 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: CPEB1_MOUSE
Sequence: MAFSLEEAAGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEETVTSRMLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTQSVLSMLQNPLGNVLGKAPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGASVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN
What is the function of this protein?
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons.  Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs.  In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity).  Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses.  Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation.  Induces the assembly of stress granules in the absence of stress (By similarity).  Required for cell cycle progression, specifically for prophase entry (By similarity).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, mCPEB, mCPEB-1.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Cytoplasm, P-body. Cytoplasmic granule. Membrane. Postsynaptic density. Note=Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density (PSD) fractions. Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin. Membrane- associated. Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs. In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment (By similarity).
Protein: NPT2C_HUMAN
Sequence: MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL
What is the function of this protein?
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379).  The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity).
What are the official names of this protein?
Sodium-dependent phosphate transport protein 2C, Sodium-phosphate transport protein 2C, Na(+)-dependent phosphate cotransporter 2C, Sodium/inorganic phosphate cotransporter IIC, Sodium/phosphate cotransporter 2C, Na(+)/Pi cotransporter 2C, NaPi-2c, Solute carrier family 34 member 3.
What is the protein family that this protein belongs to?
Belongs to the SLC34A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=ocalized at the brush border membrane in the kidney.
Protein: AMPA_YERPP
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKVGQTLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNTYWKVRQAVETAKETLYTFDQLKSNKTEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIASGIKAAKDLGNMPPNICNAAYLASQARQLADAFSTNTVTRVIGEQQMKELGMHAYLAVGHGSQNESLMSVIEYKGNPNKDAKPIVLVGKGLTFDSGGISIKPAEGMDEMKYDMCGAATVYGVMRVVAELQLPLNVVGVLAGCENMPGGRAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPELVIDIATLTGACVVALGNHLTGLMSNHNPLAHELIGASEQAGDRAWRLPLGEEYYEQLDSNFADMANIGGRAGGAITAGCFLSRFTRKYSWAHLDIAGTAWRSGKNKGATGRPVALLSQFLLNRAGLNGDD
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_YEAST
Sequence: MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY
What is the function of this protein?
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.