PharMolix/UniProtQA huggingface dataset:
Protein: PANC_YERE8
Sequence: MLIIETLPLLRQQIRRWRQEGKRVALVPTMGNLHEGHMTLVEDAKTRADVVVVSIFVNPLQFERPDDLARYPRTLQEDCEKLTRHGVDLVFAPAAADVYPAGLEAQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLVQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPIVRAKDGLALSSRNGYLSAQERKIAPQLYKIMQALAEKLALGERQIDDLLADTAEQLRDAGFTPDELFIRDAQSLQPLTVDSKQAIILMAAWLGKARLIDNQQVDLHS
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MARH4_HUMAN
Sequence: MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV
What is the function of this protein?
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF4, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, RING-type E3 ubiquitin transferase MARCHF4.
Protein: ATPF2_CERS1
Sequence: METEVHEAAGAAGHAGQAVGMPQLNFDYWPNQIFWLLVTLVAIYFLLTRVALPRIGAVLAERRGTITNDLAAAEELKQKAVLAEKAYNEALAKARAEAQAIVAETRAAIQAELDEATAKADAEISAKSAESEARIAEIRAGALQSVSEVAKDTAEALVAALGGKSDAAAVDAAVAARMKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LRKS4_ARATH
Sequence: MSQTFAVILLLLIFLTHLVSSLIQDFSFIGFKKASPNLTLNGVAEIAPTGAIRLTTETQRVIGHAFYSLPIRFKPIGVNRALSFSTSFAIAMVPEFVTLGGHGLAFAITPTPDLRGSLPSQYLGLLNSSRVNFSSHFFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSPFSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMSGEAFSLSLPSLPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVKDEDRVEEWELDFGPHRFSYRELKKATNGFGDKELLGSGGFGKVYKGKLPGSDEFVAVKRISHESRQGVREFMSEVSSIGHLRHRNLVQLLGWCRRRDDLLLVYDFMPNGSLDMYLFDENPEVILTWKQRFKIIKGVASGLLYLHEGWEQTVIHRDIKAANVLLDSEMNGRVGDFGLAKLYEHGSDPGATRVVGTFGYLAPELTKSGKLTTSTDVYAFGAVLLEVACGRRPIETSALPEELVMVDWVWSRWQSGDIRDVVDRRLNGEFDEEEVVMVIKLGLLCSNNSPEVRPTMRQVVMYLEKQFPSPEVVPAPDFLDANDSMCLDERSGSAGEFEDFVDSARFYSGPNETTTSSIFSFSGKTRTDPR
What is the function of this protein?
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae.
What are the official names of this protein?
L-type lectin-domain containing receptor kinase S.4, LecRK-S.4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: LUCI_LUCMI
Sequence: MEMEKEENVVYGPLPFYPIEEGSAGIQLHKYMHQYAKLGAIAFSNALTGVDISYQEYFDITCRLAEAMKNFGMKPEEHIALCSENCEEFFIPVLAGLYIGVAVAPTNEIYTLRELNHSLGIAQPTIVFSSRKGLPKVLEVQKTVTCIKKIVILDSKVNFGGHDCMETFIKKHVELGFQPSSFVPIDVKNRKQHVALLMNSSGSTGLPKGVRITHEGAVTRFSHAKDPIYGNQVSPGTAILTVVPFHHGFGMFTTLGYFACGYRVVMLTKFDEELFLRTLQDYKCTSVILVPTLFAILNKSELIDKFDLSNLTEIASGGAPLAKEVGEAVARRFNLPGVRQGYGLTETTSAFIITPEGDDKPGASGKVVPLFKVKVIDLDTKKTLGVNRRGEICVKGPSLMLGYSNNPEATRETIDEEGWLHTGDIGYYDEDEHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPNIFDAGVAGVPDPDAGELPGAVVVMEKGKTMTEKEIVDYVNSQVVNHKRLRGGVRFVDEVPKGLTGKIDAKVIREILKKPQAKM
What is the function of this protein?
Produces green light with a wavelength of 570 nm.
What are the official names of this protein?
Luciferin 4-monooxygenase, Luciferase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: HIF1A_EOSFB
Sequence: MEGAAGGEEKKNRMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPIKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYNDVMFPSSDDKLTSINLAMSPLPASETPKPLRSNADPALNQEVALKLEPNAESLELSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSPNPPSVSTAFQQTQLQEPTITTTTTEELKTVTKDSTEDIKILITSPSSTHTPKETTTATTSSPYSGTQSRTASPNRAGQGVIEQTEKSHPRSPNVLSVTLSQRNTVPEEELNPKIIALQNAQRKRKMEHDGSLFQAAGIGTLLQQPDDRAPATSLSWKRVKGCKSSGQNGMEQKTIILIPSDLACRLLGQSMDGSGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
What is the function of this protein?
Functions as a master transcriptional regulator of the adaptive response to hypoxia.  Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.  Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity).  Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).  Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300.  Activity is enhanced by interaction with NCOA1 and/or NCOA2.  Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.  Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles. Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Protein: NUOC_MYCS2
Sequence: MSTSNGSANGTNGVGLPRGDEPEIIAVRRGMFGNRDTGDTSGYGRLVRPVALPGSTPRPYGGYFDAVMDRLAEVLGEERYAMSIERVVVYRDQLTIEVSRVQLPAVASVLRDDPDLRFELCLGVSGVHYPEDTGRELHAVYPLMSITHNRRIQLEVAAPDADPHIPSLYAVYPTTDWHERETYDFFGIIFDGHPSLTRIEMPDDWEGHPQRKDYPLGGIPVEYHGAQIPPPDQRRSYS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FAS2_PENPA
Sequence: MRPEVEQELAHTLLVELLAYQFASPVRWIETQDVILAEQRTERIVEIGPADTLGGMARRTLASKYEAYDAATSVQRQILCYNKDAKEIYYDVDPVEEEPEATEPAPSATPAAPAAAPAAGAPPPPPSAGPAASVEDIPVTAVDILRTLVAQKLKKSLADVPLSKAIKDLVGGKSTLQNEILGDLGKEFGSTPEKPEDVPLDELGASMQATFNGQLGKQSSSLIARMVSSKMPGGFNITSVRKYLETRWGLGSGRQDGVLLLALTMEPAARLGSEVDAKAYLDDVTNKYAASAGVNLSAPVAGGDSGGAGGGMVMDPAAIDALTKDQRALFKQQLEIIARYLKMDLRGGEKAHVISQETQKALQAQLDLWQAEHGDFYASGIEPSFDQLKARVYDSSWNWARQDALSMYYDIIFGRLQVVDREIVSQCIRIMNRSNPLLLDFMQYHIDNCPTERGETYQLAKELGQQLIENCREVLEVAPVYKDVAVPTGPQTTIDARGNISYKETPRTSARKLEHYVKHMAEGGPISEYSNRTKVQNDLKSVYKLIRKQHRLSKSSQLQFDALYKDVVHALGMNESQIIPQENGHSKKGGRSAAKRNTPTRPGKVETIPFLHLKKKTEHGWDYNKKLTGIYLNVTESAAKDGLSFQGKNVLMTGAGAGSIGAEVLQGLISGGAQVIVTTSRFSREVTEYYQAMYARYGARGSQLVVVPFNQGSKQDVEALVEYIYDTKKGLGWDLDFVVPFAAIPENGREIDSIDSKSELAHRIMLTNLLRLLGSVKTQKQAHGFETRPAQVILPLSPNHGTFGNDGLYSESKLALETLFNRWYSENWGHYLTICGAVIGWTRGTGLMSGNNMVAEGVEKLGVRTFSQQEMAFNLLGLMSPAIVNLCQLDPVFADLNGGLQFIPDLKGLMTKLRTDIMETSDVRQAVMKETAIEHNIVNGEDSGVLYKKVIAEPRANIKFEFPNLPDWEKEVKPLNENLKGMVNLDKVVVVTGFSEVGPWGNSRTRWEMESKGKFSLEGCVEMAWIMGLIKHHNGPLKGQAYSGWVDAKTGEPVDDKDVKPKYEKHILEHTGIRLIEPELFKGYDPKKKQLLQEIVIQEDLEPFEASKETAEEFKREHGDKVEIFEIPESGEYTVRLCKGATMLIPKALQFDRLVAGQVPTGWDASRYGIPDDIISQVDPVTLFVLVCTAEAMLSAGVTDPYEFYKYVHLSEVGNCIGSGIGGTHRLRGMYKDRFLDKPLQKDILQESFINTMSAWVNMLLLSSTGPIKTPVGCCATAVESVDIGYETIVEGKARVCFVGGFDDFQEEGSYEFANMKATSNAEDEFAHGRTPQEMSRPTTTTRAGFMESQGCGMQLIMTAQLALDMGVPIHGIIALTTTATDKIGRSVRSVPAPGQGVLTTARENPGKFPSPLLDIKYRRRQLDLRKKQINEWQEAELLYLQEEAEAMKAQSDETFNEAEYMQERAQHIEREAIRQEKDAQYSLGNNFWKQDSRIAPLRGAMATWGLTVDDIDVASFHGTSTVANDKNESDVICQQMKHLGRSKGNAVMGIFQKYLTGHPKGAAGAWMFNGCLQVLDSGLVPGNRNADNVDKVMEKFDYIVYPSRSIQTDGVKAFSVTSFGFGQKGAQVIGIHPKYLYATLDQAQYEAYKTKVEARQKKAYRYFHNGLINNSIFVAKSKAPYEDEQQSKVFLNPDYRVSVDKKTSELKFSTTAPEAKQSESTRQTLESLAKANATENSKIGVDVEHIDSVNIENETFVERNFTQSEQDYCRKAASPQSSFAGRWSAKEAVFKSLGVSSKGAGAALKDIEIGVDANGAPVVNLHGAAAAAAKQAGVKQVSVSISHSDSQAVAVAVSQF
What is the function of this protein?
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH.  The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.
What are the official names of this protein?
Fatty acid synthase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.
Protein: DRT2_PHAJA
Sequence: SLGGFLKGVGKALAGVGKMVADQFGNLLQAGQ
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Dermatoxin-J2, DRT-J2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermatoxin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: URED_MICAN
Sequence: MWQGNLELIYKQKNLATEINHVYATAPLKVQRPFYPEGKNLCHTVILHTAGGIVGGDVLQQKIHLQAATNALITTASAGKVYQSNGQMAQQLIEIKIDDNASLEWLPQETIIFNGAAFRQHLRVDLGENSSWLGWEITRFGRSARGEKFLAGEWHSNWEIWRSGQPLWLDRSCLLGGKMIEGFSGLNDSALIGTLVYIGQPVGRNLIEKVRDFSLEGERGVTNTLGDGLLCRYRGNSSGEVRQWFQQVWQILRREMSDQEAIIPRVWLSW
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNRE_PLAL2
Sequence: MEICPFVRLLDWRTLRAADCLTARQSREVDRFAIEELGISSLVLMENAARSVCDWFSQHVQASSSEETSFVVRVVCGRGNNGGDGFAIARLLWTMGYAVEIFATHPEAELAPDARVNAALARKLGIPWREMREFGEAAASARAEDWIVDAILGTGQSRPLSGVLAELVQGMNASLSRRLAVDLPTGFSADAGPGLGNPLTEQPHELVELCVRADVTVTFVTPKMGMLHPGAREYLGETFVASIGLPEKLLREAVSLQ
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: OR98A_DROME
Sequence: MLFNYLRKPNPTNLLTSPDSFRYFEYGMFCMGWHTPATHKIIYYITSCLIFAWCAVYLPIGIIISFKTDINTFTPNELLTVMQLFFNSVGMPFKVLFFNLYISGFYKAKKLLSEMDKRCTTLKERVEVHQGVVRCNKAYLIYQFIYTAYTISTFLSAALSGKLPWRIYNPFVDFRESRSSFWKAALNETALMLFAVTQTLMSDIYPLLYGLILRVHLKLLRLRVESLCTDSGKSDAENEQDLIKCIKDHNLIIDYAAAIRPAVTRTIFVQFLLIGICLGLSMINLLFFADIWTGLATVAYINGLMVQTFPFCFVCDLLKKDCELLVSAIFHSNWINSSRSYKSSLRYFLKNAQKSIAFTAGSIFPISTGSNIKVAKLAFSVVTFVNQLNIADRLTKN
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
What are the official names of this protein?
Odorant receptor 98a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2366_MYCTU
Sequence: MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG
What are the official names of this protein?
UPF0053 protein Rv2366c.
What is the protein family that this protein belongs to?
Belongs to the UPF0053 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1074_METJA
Sequence: MAIAYAKLYELIHKKIKDEREADELYNAIIEIIKESKVIVKNELKDELKDELATKKDIDLVREEMKAMEERILRYVDNRFNQLLIVQLIILFAIIITNPNAIELIKLLFGFK
What are the official names of this protein?
Uncharacterized protein MJ1074.
What is the protein family that this protein belongs to?
Belongs to the M.jannaschii MJ0023/MJ0349/MJ1072/MJ1074/MJ1107/MJECL16 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SQS1_YEAS7
Sequence: MAKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPTNSWHNSSIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNRYDSSTDLQAGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENEDDDSQNSPSTDHSLSSNESKVEDGDLFFVDEEAQQSPDLTKIKRVCIEEIARPREVAIEFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSEVDQGFNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLSSPASEELEFGFKEEDFVINTNDIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVVDELGLPEDRLPAYLNFIKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHSDIEEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIETKAKKRKAKEDFIDQENRNSNDMLKKYPYGLHIQNIKDEFESFLSRNNDRLTFPPLDPHGNKTVMKIAKHYNMKSSKIGKANHTSVVVEKIKKTKWSSPNYSLIDQLMRQRPVFMRIDIRRPREEQAAFERTKTIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGLGIQGNKGISEPIFAKIKKNRSGLRHSES
What is the function of this protein?
May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants.
What are the official names of this protein?
Protein SQS1, Squelch of splicing suppression protein 1.
What is the protein family that this protein belongs to?
Belongs to the SQS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPE_SHELP
Sequence: MTSNRSTAWPAPAKLNLFLHVNGRRADGYHELQTLFQFIDYCDYLDFAVNDSGSLTLHSEMEAVVANSDNLILKAAKSLQEYTGTHQGAEIWLDKKLPMGGGIGGGSSDAATTLVALNHLWQTQLSQDELAKIGLSLGADVPVFINGLAAFAEGVGEKLIPVEAPENWYLILTPDVHVSTAEVFNDPLLPRDTPKLSMDDLMSSDWHNDCQPRVAERYPQVAKALAWLIEYAPSRMTGTGACVFGIFDTRQQAEHVFAKLPAGLCGFIAKGTNKSPLALRLTQH
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: GLR_RAT
Sequence: MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
What is the function of this protein?
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.  Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.  Plays an important role in mediating the responses to fasting.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Promotes activation of adenylate cyclase.  Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Glucagon receptor, GL-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
Protein: TRPC3_RAT
Sequence: MSTKVKKCREPARVTLPAPEEEDGEAEGAEPQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSALRCE
What is the function of this protein?
Forms a receptor-activated non-selective calcium permeant cation channel.  May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
What are the official names of this protein?
Short transient receptor potential channel 3, TrpC3, Trp-related protein 3.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y697_METVS
Sequence: MIRDTVVSGIFYPLEYHDLIEMIEYCYLNPRGPKKLPSKLGRYEKPIGVISPHAGYVYSGPIAAHSYKEISKKVSGNITAVIIGPNHSGMGSVVSTMEGIWKTPLGNLEIDNEFSERLWKECDIIDLDETAHLKEHSIEVQLPFLKHLELLNIAKFKFVPISMSLQDYDTAVGVGYMVAKVAKELNRKIIIIASSDFSHYEPEEIASKKDAIIIKDILKMEEEEIFTDVVTNNVTMCGYGPIIAMIKAMKVLGAKESKLLSYSTSGDVTKDYSEVVGYGALIIE
What are the official names of this protein?
MEMO1 family protein Mevan_0697.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: SYS_GEOSL
Sequence: MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISKVKDKSQIQDKIAEMREVGVRIKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNRQVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALVNFMLDLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRAEILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKLLSNAEEVLRQLGLAYRVVELCTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSRRASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQEDGSVVIPDVLRPYMGGLQKIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPCH_SALAR
Sequence: MKNAFKDALKAGRPQIGLWLGLANSYSAELVAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLVPMVQNADEARDAVAATRYPPAGIRGVGSALARASRWNRIPDYLHEANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPAVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: GCH1_ECOL5
Sequence: MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRHEFLRAVRHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: IFNG_FELCA
Sequence: MNYTSFIFAFQLCIILCSSGYYCQAMFFKEIEELKGYFNASNPDVADGGSLFVDILKNWKEESDKTIIQSQIVSFYLKMFENLKDDDQRIQRSMDTIKEDMLDKLLNTSSSKRDDFLKLIQIPVNDLQVQRKAINELFKVMNDLSPRSNLRKRKRSQNLFRGRRASK
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.