PharMolix/UniProtQA huggingface dataset:
Protein: APOA1_MUSPF
Sequence: MKAVVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDAVKDGGRDYVAQFEASALGKQLNLKLLDNWDSLSGTVAKLREQIGPVTQEFWDNLEKETEALRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVELYRQKVAPLGTELREGARQKLQELQEKLTPLGEELRDRARTHVDALRAHLAPYSDQLRERLATRLQALKEGGSASLAEYHAKASEHLSALSEKAKPALEDLRQGLLPVLESFKVSLLAAVDEAAKKLNTQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility.
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUFP_OSTLU
Sequence: MASLPARRIRNFSIIAHIDHGKSTLADTLLMRTKTVKERDMVKQVLDSMDLERERGITIKLNSARMDYVASDGELYVLNLIDTPGHVDFSYEVSRSLAACEGALLVVDSSQGVEAQTVANVYLALENDLEIFTVLNKIDLAGSEPDRVKQEIEDVLGLDASDAILASAKANIGMDDILERIVQVVPPPRDTANEPLRALIFDSYFDPYRGVVAVFRVMDGTMKTGDAMKMMATGATFAADEIGIMRPDKVPVKELGPGEVGYIIGGIKSVADARVGDTITLSKNPAAEALPGYSKSVPMVFAGIFPTDTDRYDDLRESLQRLQINDCSLSFEPEQNSAMGTGFRCGFLGLLHMEIIQERLEREYDLDLITTAPSVVYNVYRTDGTMDSISNPADLCPPELRERIEEPYCRLDMIAPSDYVGTLMELASQRRGEFIDMTYLSETRTSIKYDIPLAEVVTNYFDDMKSRSRGYASMEYAITGYRQSDLVRLDVLINQEPADPLAVITHRDRAYSIGRQLVDKLKELIPRQMFRIPIQAAIGNKVIAATSISAMRKDVTAKCYGGDISRKKKLLKKQAAGKKRMKQFGKVEVPQDAFLAVLSVDGAAD
What is the function of this protein?
Promotes chloroplast protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
What are the official names of this protein?
Translation factor GUF1 homolog, chloroplastic, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ZN622_MOUSE
Sequence: MAALTCITCRVAFRDAELQRAHYKTDWHRYNLRRKVAAMAPVTAEGFQERVRAQRAVAEAAEASKGAATYCTACGKKFATFNAYENHLGSRRHAELERKAVRAASRRVELLNAKNLEKGLGADGVDKDAVNAAIQQAIKAQPSTSPKKAPFVPTDECGRAAAGARGVPERDPTEKPPRLQWFEQQAKKLAKQQWEDGEEEGEEEEEDDEDEDWEDIDSDDGLECEDPGVEDQDAEDAAAEESPPLGAIPITDCLFCSHHSSSLVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAELEALSTDKILECDDETMELILPSGARVGHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWMGSTGAALMRERDMQYVQRMKSKWMLKIGMKNNATKQMHFRAQVRF
What is the function of this protein?
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.
What are the official names of this protein?
Cytoplasmic 60S subunit biogenesis factor ZNF622, Zinc finger protein 622.
What is the protein family that this protein belongs to?
Belongs to the REI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GAJB_BACC5
Sequence: MSLSKIIPSNKKEEQKSINAIFNSIDKSEGIIFNSGAGAGKTYALIESLKYIIRNYEKSLKQHNQQIICITYTNVATKEVKERLGNTDLVLVSTIHERMWGLIKDYQKELVEIHKEKLEDEISSLKQKLEKGQGYEKFQELEEDLKGNFKKIMIENRELFFQNYSAKAAEVKKSFKILLNDYPNMLKNVGNFKRIVNAIYKLDQYSKCYENISLNKQGYKSVEYNSIYNNDQLYKMRISHDTLLDYGLKIIKKYDLLKQIIIDKYPFIFIDEYQDTDEKVILIMSYLEQYAKKIDHKIFIGYFGDTAQNIYDDGVGSEITKIHSGLKQIDKVFNRRSTKEVIEVINKIRNDSIEQISIYDDCEGGSVKFYKGTSGNVKDLIERYIYEWKITTENQLHCLVLTNKIVAEYSGFKNIYEAFKETDKYKGSNYNQLNTELLSNDLSKLGEIPKLLFNIVRLQNNLVDKTTSVIDITPKESLFDEMSIEGLRNLIKLLKQYQGKTLGEYIESISTVYSQVNDENYKKIIDWTFGFENITFELFKNHLIEKLFNNILDDDVDRATATIQKILEVDIVEYGLWYKFIMDKQEEKVIYHTYHGTKGREFDNVIIIMENAFGRNHNYFNFFFENFLHPDVLEGEKKLNFEKIKNLLYVSCSRAIKNLRVLYIDDVTDFESEIKEMFGEVYPF
What is the function of this protein?
Component of antiviral defense system Gabija type II, composed of GajA and GajB.  Expression of Gabija type II in B. subtilis (strain BEST7003) confers resistance to phages phi105, and SpBeta (PubMed:29371424).  May be a helicase or contribute to GajA activation (Probable).
What are the official names of this protein?
Gabija protein GajB, Putative helicase GajB.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
Protein: EZRA_STAA2
Sequence: MVLYIILAIIVIILIAVGVLFYLRSNKRQIIEKAIERKNEIETLPFDQNLAQLSKLNLKGETKTKYDAMKKDNVESTNKYLAPVEEKIHNAEALLDKFSFNASQSEIDDANELMDSYEQSYQQQLEDVNEIIALYKDNDELYDKCKVDYREMKRDVLANRHQFGEAASLLETEIEKFEPRLEQYEVLKADGNYVQAHNHIAALNEQMKQLRSYMEEIPELIRETQKELPGQFQDLKYGCRDLKVEGYDLDHVKVDSTLQSLKTELSFVEPLISRLELEEANDKLANINDKLDDMYDLIEHEVKAKNDVEETKDIITDNLFKAKDMNYTLQTEIEYVRENYYINESDAQSVRQFENEIQSLISVYDDILKEMSKSAVRYSEVQDNLQYLEDHVTVINDKQEKLQNHLIQLREDEAEAEDNLLRVQSKKEEVYRRLLASNLTSVPERFIIMKNEIDHEVRDVNEQFSERPIHVKQLKDKVSKIVIQMNTFEDEANDVLVNAVYAEKLIQYGNRYRKDYSNVDKSLNEAERLFKNNRYKRAIEIAEQALESVEPGVTKHIEEEVIKQ
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: RSMH_ECODH
Sequence: MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTHA_HAEPH
Sequence: MGFHSKNNSEYNGDFIILSSIYYWMILLYCIKFFLSKYLIYCMSLTYIDLFSGAGGFSLGFDRAGFHQLLSVEIEPHYCDTYRANFPDHQVLQQDLTTLSDDNLLRHINHRKVDVVIGGPPCQGFSMAGKIGRTFADDPRNHLFKEFVRVVKLTQPKFFVMENVARLFTHNSGKTRAEITEQFERLGYKVKCKVLNAADFGVPQLRSRIVFIGRKDGGEITFPEPSHTEYNTVGDAIGHFPKLNAGENSLILNHEAMNHSTQMLEKMSFVKNGGDRNDIPESLRPISGDVRKYIRYHSDKPSVCVTGDMRKVFHYEQNRALTVRELAALQSFPDDFVFLGKKIAQQQQVGNAVPPLLAQAIAEAVLKMNTNE
What is the function of this protein?
A methylase that recognizes the double-stranded sequence 5'-GGTGA-3' and protects the DNA from cleavage by the HphI endonuclease (PubMed:8759008).  Probably methylates C-2 on the bottom strand (Probable) (PubMed:12654995).
What are the official names of this protein?
Type II methyltransferase M1.HphI, M1.HphI, Cytosine-specific methyltransferase HphIA, M.Hphi(C), Modification methylase HphIA, M.HphIA.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: EIF3M_CAEEL
Sequence: MADTRELPVFAYIDDVKQLQELRQYLNKHDSVKLDPNGPSETAQNMIEICSTLNVLPSWSQDVDLVLNSISSLIVVVPGEKCEPVVDSFIKNVAPQFYKGTGWASHAGIAVRVLSNLYKGYSNFHTVQEKIFKALVDMCAEARLIGELECNLETLQDRFNTWKTPVEGQREILRAVHRALLVDQRVDQAAKVMTALLGTYTEKDAAAARDDAMECVRTAVVDPKSFSFDHLERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKFVTEHLKVDETILLKKIRLLTLMSLAEEKNEISLDELAKQLDILADETLEEFVIDAIQVNAISGKINEMARTLIVSSYQHRRFGTEQWVLLEKRLKVLIANLKQTHNNVHEVNQRIEAL
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential).  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (PubMed:17403899).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF (PubMed:17403899).  The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo.  Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3 (PubMed:17403899).
What are the official names of this protein?
COP9/Signalosome and eIF3 complex-shared subunit 1, COP9 signalosome complex subunit 7, Signalosome subunit 7, Eukaryotic translation initiation factor 3 subunit M, eIF3m.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_SHESH
Sequence: MSDPFSEAQHQLDALGLRCPEPVMMVRKSVRKMAQGETLLIIADDPATTRDIPSFCEFMDHKLLASQTDSTPYQYLIQKGL
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPA_STAAC
Sequence: MKQGTVKWFNAEKGFGFIEVEGENDVFVHFSAINQDGYKSLEEGQAVEFEVVEGDRGPQAANVVKL
What is the function of this protein?
Involved in cold stress response and in the susceptibility to an antimicrobial peptide of human cathepsin G (CG117-136).  Regulates yellowish-orange pigment production through a still unclear SigB-dependent mechanism.
What are the official names of this protein?
Cold shock protein CspA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_CERS1
Sequence: METEVEHTGLAIHPMDQFIVKKLFCHTESTAPMNECTTNIHWYDITNVTMWMAIAVLVIAAILVLGTRRRAIVPSRSQSVAELLYGFIHNMVEEVTGHEGVKYFPYVMTLFLFVLCGNVLGLLPLSFTTTSHMAVTVPLALMVFVGVTALGFMKNGPGFLKMFWVTSAPLAIRPVLAVIEVISYFVRPVSHSIRLAGNMMAGHAVIKVIAGFASIVVVSPVVVGAVTAIYALELLVAVVQAYVFTILTCVYLRDAVGDAHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMD_RUEST
Sequence: MSDTPDLAGVWKAKILTLFPEAFPGVLGESLTGKALQQGLWQLETVDLRPFGIGKHKNVDDTPAGGGAGMVLRADVLGDAIEHAMQGTAGNWPLIYLSPRGRRMDQQMMQTFARCDGLTLLCGRFEGVDERVLEHYGIQEVSLGDFVMTGGELAAQALIDATVRLIPGVLGNQASTEEESFSSGLLEHPQYTRPADWKGRAIPDVLMSGHHGKIAEWRQDMSEKITQERRPDLWAAYQARKSKT
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPA_MYCBO
Sequence: MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
What is the function of this protein?
Supports mycobacteria survival during infection by modulation of the phagosome maturation and modulation of the normal host signaling pathways, including host innate immune responses and cell apoptosis.
What are the official names of this protein?
Low molecular weight protein-tyrosine phosphatase A, LMW-PTP, PTPase, Low molecular weight tyrosine phosphatase PtpA.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: DXR_BORA1
Sequence: MSGFQRIAVLGSTGSIGDSTLDVIARYPERFGVYALSAFSRMDKLAAQALATGAAVVVVPDNNAATRFRQAWSPSRALPEIRVGAQALADTAADAGCDTVMAAIVGIAGLPAALAAAQSGKRVLLANKEALVAAGSIFMSAVRQSGAELLPIDSEHNAIFQCLPQGERAGAPSTPAKTVRKLILTASGGPFRRHSPEDLQDVTPDQACAHPNWSMGRKISVDSATMLNKGLEVIEAHWLFAMPADRIEVLIHPQSVVHSLVEYDDGSVLAQMGQPDMRTPISYGLGFPERLDAGVSPLDLAKWGRLDFETPDLERFPCLRLSYEALRAGQAACVALNAANEIAVAAFLEGRLPYPWIARVIDAALEWQAGRPSVTLDHLTDVLALDAQVRAYAGNLGLA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: ENTP5_AILME
Sequence: MATTWGAAFFMLVASCVCSTVFHRDQQTWFEGVFLSSMCPINVSASTLYGIMFDAGSTGTRIHIYTFVQKIPGQLPILEGEIFESVKPGLSAFVDQPKQGAETVEELLEVAKDSVPRSHWKRTPVVLKATAGLRLLPEQKAEALLFEVREIFRKSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGHSQKTVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGIDGHTFRSACLPRWLEAEWIFGGVKYQYGGNKEGNEGSGEVGFEPCYAEVLRVVQGKLHQPDEVRKSSFYAFSYYYDRAADTDMIDYETGGVLKVEDFERKAREVCDNLEKFTSGSPFLCMDLSYITALLKDGFGFADSTILQLSKKVNNIETGWALGATFHLLQSLGISH
What is the function of this protein?
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity).  In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases.  UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose.  Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose.  Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Uridine-diphosphatase ENTPD5, UDPase ENTPD5.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted.
Protein: RPOC1_SOYBN
Sequence: MIDQYKHQQLRIGSVSPQQISAWAKKILPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIRDKKDDPKFCEQCGVEFIDSRIRRYQMGYIKLACLVTHVWYLKRLPSYIANLLDKSLKELESLVYCDFSFARPVVKKPTFLRLRGSFEYEIQSWKHSIPLFFTTQGFDIFRNREISSGAGAIREQLADLDLRILMDSSLIEWKELGEEGSPDNENEWEDRKVGRRKNFLVRRIELAKHFLRTNIEPEWMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLIDLLTTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDIIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFLIRGLIRKHFASNIGIAKSKIREKEPIVWEILQEVMQGHPVLLNRAPTLHRLGIQAFQPILVEGRAICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHTNLLSPAIGDPISVPTQDMLIGLYILTSGNRRGIYSNRYNPRNCGNFRNLKNERIRDNNYKYTKKKEPFFCNSYDAIGAYQQKRINFDSPLWLRWRLDQRIISSREVPIEVHYESLGTYHEIYEHYLVVRSTKKEIRSIYIRTNVGHISFYREIEEAIQGFCRAYSYDI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TPM_METEN
Sequence: MKLEKDNAMDRADTLEQQNKEANNRAEKSEEEVHNLQKRMQQLENDLDQVQESLLKANNQLVEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin, Allergen Met e I.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: RRF_ACIBY
Sequence: MINDLKKDSEQRMLKTLESLEQGFAKVRTGRAHPSILNGVMVPYYGSDVPLNQVANVGVEDSRTLIVQPFERTMVAAIDKAIRESDLGLNPITADSIRVPLPALTEETRRDMQKIARSEAENAKVAIRNIRRDVLGDIKALLKEKEISEDDERRAGDDIQKITDKYVAEVDKRLAAKEAELMKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGB_BACC2
Sequence: MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA.  The LrgAB and CidA proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: M2_I02A7
Sequence: LLTEVETPTRNEWECRCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTAGVPESMREEYRQEQQSAVDVDDGHFVNI
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion) (By similarity).
Protein: Y680_RHILO
Sequence: MKLTWYGHSAFRIETGDAKILIDPYLIGNPSWTGGWEGPAEGITHVLLTHGHSDHISGALEVLGKSGAQLVANFEICMYLVGKGADGSKINPGNIGGTVDCGGFTTTFVQALHSSSFGEDGGKNVYLGNPGGLVLHFPEDRTLYHMGDTDIFSDMALINELHEPKIGIVPIGDRFTMGGAVAALACRRFFKFDTVVPCHFGTFPMIDPTPEKFEAGLEGSGVKVALPKIGETITI
What are the official names of this protein?
UPF0173 metal-dependent hydrolase mll0680.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: PAF1_RAT
Sequence: MAPTIQTQAQREDGHRPNSHRTLPERSGVVCRVKYCNSLPDIPFDPKFITYPFDQNRFVQYKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVLLDPADEKLLEEEIQAPTSSKRSQQHAKVVPWMRKTEYISTEFNRYGISNEKPEVKIGVSVKQQFTEEEIYKDRDSQITAIEKTFEDAQKSISQHYSKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDTSGAAALEMMSQAMIRGMMDEEGNQFVAYFLPVEETLKKRKRDQEEEMDYAPDDVYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYNELETRVRLSKRRAKAGVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMEAEEKEAGGSDEEHEKGSSSEKEGSEDERSGSESDREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAHRGSDNDSDSGSDGGGQRSRSQSRSRSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex.  Involved in polyadenylation of mRNA precursors (By similarity).
What are the official names of this protein?
RNA polymerase II-associated factor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the PAF1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Protein: MURA_BARHE
Sequence: MDSIEIVGGKKLKGIIPISGAKNAALPLMIAALLTEETLSLDNIPHLADIELLIRILNNHGVGYAVDGQKNHTECVHSRTIHFTAQKITTTYAPYDLVRKMRASFWVIGPLLARCREAYVSLPGGCAIGTRPVDFILEGLKTLGARITIENGYVHAKVPKGLKGAHYRFPKVTVGGTHVMIMAAVTANGKTVLENAACEPEVTNLVQALNAMGAKITGEGTTILTIEGVQKLNGARISVIPDRIEAGTYAMAVAMTGGDVMLKNANPHHLTQVLEILQKTGLDIEIKPQGIHLKRNLRQTKIMPVDIKTGPYPAFPTDLQAQFMALMTRAQGISHITETIFENRFMHVQELNRLGAQIKLDGQTATVFGTEHLQGAPVMATDLRASVSLVIAALAAKGKTTVNRVYHLDRGFERLEEKLARCGATIQRITV
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPI2_BRUMA
Sequence: MMSTMSIKEGLLVILLSLFLFDTTALIHRREIPHMESKGQMQRGQVLLGGWQERSPEDNEILELLPSVLTKVNQQSNDEYHLMPIKLLNVSSQVVAGVKYKMEVQVARSECKKSASEQVNLKTCKKLEGHPDQVMTLEVWEKPWEDFLQVNILETKVLSSV
What is the function of this protein?
Cysteine protease inhibitor which inhibits members of the peptidase C1 family.  Also acts as an asparaginyl endopeptidase inhibitor (PubMed:11301256, PubMed:15664654).  In the human host, inhibits CTSL/cathepsin L, CTSS/cathepsin S, CTSB/cathepsin B and asparaginyl endopeptidase LGMN/AEP which may cause defects in both antigen and MHC class II invariant chain CD74/Ii processing (PubMed:11301256).
What are the official names of this protein?
Cystatin cpi-2.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.