PharMolix/UniProtQA huggingface dataset:
Protein: POTA_LEUMM
Sequence: MSEKQVPIIAFNQVDLSFGDTHVLNNVDLEIEAGKFYTLLGPSGSGKSTILKLISGQLTADSGDISFEGQRVNDVPAEKRKVNTVFQNYALFPNMNVFDNVAFGPTLKGMNKTEIKNKVKEMLNLVKLSDFVDREIDELSGGQQQRVAIARALANDPEVLLLDEPLSALDYKLRKSMQYELREIQQRLGITFVFVTHDQEEALAMSDWIFVMNDGVIQQNGSPEDIYDEPINHFVADFIGESNIVDGIMKEDYVVHFVGKDFENVDAGMRPNERVEVVLRPEDLDLTSIENGKLVVTIEDQSFRGDYYEITARDDDGNEWQVQATNSAIIGARVGLTFDPEDIHIMRFNESEDDFDARLESYEDDDEI
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYH_BUCAP
Sequence: MNKKINSVRGMHDYLPEELKIWKKIENIIQKILTSYCYEEIRLPILEKTKIFQRAIGNITDVVEKEMYSFKDKKGNSLTLRPEGTVGCVRAIIENNLLFQKKQRFWYLGPMFRYERPQKGRYRQFYQLGVEVFGLNTPDIDLEIILLISRLWKCLGINLHIKLEINSIGSKLDRIKYQKELVFFLEKYKNILDEDSKKRLYTNPFRILDSKNDMMQKILKKAPLLKNYINTSAINHFNSLCNMMDSYGIKYIHNQNLVRGLDYYNSTVFEWKIDQIGSQNTICAGGRYDSLVQELGGNKTSAIGFAIGIERLVLLIKSLNIISCKEEDINIYIIFIGELNKIYAISLSEEIRNIYPKLKIFVDFMTCSLSKKIKNAVDSLAHIAILIGANEIKKNCFLLKDLKRGREYFFSKSELILKIKKIFYKQGN
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E1B55_ADET1
Sequence: MAQNNSDGVEGASPAKRRRLDQVTYSEICADFRSGSFSDFFMEKYNFAQVASYKMQPDDDWTDMIAQHAKIELDPTKEYVILSTVFIQSNCYIIGHGAKIVIVGEPGIAFKVLTKSFGPVITNMWAVSFTDCVFQRRDSYNGKVFTCASQVLFHNCFFVGFTGTCITSTAALTVRGCQFLACYRPIMFLAAFDLTVKHCVFDKCVIAISTEGDFEISSNLCTDSCCFLSAAGTGIFSYNSIVNPFTLQDSAEFSMVTCADAKVQLLHTIHIHSNPKLVYPQFMHNVLLRAKLFVGRRRGGFHPHFCSLKYSLLTLAKGSERKVNLSTCYPDGLKVYKVLNRNPNRLFTRLCECDASHQTADIVLGEVGLPATADPTLDSVDCLEFSSDEEW
What is the function of this protein?
Plays a major role to prevent cellular inhibition of viral genome replication.  Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.  This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM.  Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.  E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain.  E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
What are the official names of this protein?
E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B protein, large T-antigen homolog, E1B-495R.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 55 kDa protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53.
Protein: CO9A3_HUMAN
Sequence: MAGPRACAPLLLLLLLGELLAAAGAQRVGLPGPPGPPGPPGKPGQDGIDGEAGPPGLPGPPGPKGAPGKPGKPGEAGLPGLPGVDGLTGRDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGPPGGIGLRGPPGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPSICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGDPGPPGPAGLPGSVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKGTPGVAGPSGEPGMPGKDGQNGVPGLDGQKGEAGRNGAPGEKGPNGLPGLPGRAGSKGEKGERGRAGELGEAGPSGEPGVPGDAGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGQKGSMGDPGLPGPQGLRGDVGDRGPGGAAGPKGDQGIAGSDGLPGDKGELGPSGLVGPKGESGSRGELGPKGTQGPNGTSGVQGVPGPPGPLGLQGVPGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGAAGAGLDGPEGDQGPQGPQGVPGTSKDGQDGAPGEPGPPGDPGLPGAIGAQGTPGICDTSACQGAVLGGVGEKSGSRSS
What is the function of this protein?
Structural component of hyaline cartilage and vitreous of the eye.
What are the official names of this protein?
Collagen alpha-3(IX) chain.
What is the protein family that this protein belongs to?
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HIS3_ACIET
Sequence: MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKLWFKGEESGHVQQVHDIRLDCDSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAVDPVLKDPESIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_PELTS
Sequence: MRIMGLDLGDKKIGVALSDPMGWTAQGLDVIAVKGPPEASVERISELVRQYGVGKIVVGLPRNMNGSFGPRAERARAFAGCLAGALNLPVELWDERMTTLEAEKLLIEADLSRARRRQVIDKMAAVLILQSFLDSQGRPRREAGGKNPGGPEEP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_SHEFN
Sequence: MIDKTIPLVDLHRHLDGNVNVKTIWELGHQHGIQLPANSLEELAPFVQIQGKENNLVDFLKKLDWMVAVLADLDAVKRVAYENVIDAASQGLDYAELRFSPYYMAMNHNLPIEGVVEAVIDGVRAGVKEHDISVNLIGIMSRSFGQEKCRLELEGILAHRDSIVAMDLAGDELGFPGDLFTEHFKRVRDAGLQVTAHAGEAAGAESMWQAINILGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVKDYDVHPLRKFMDAGVLIGLNTDDPGVSAIDIAHEYRVVKSEMGFSDSQLATLQRNGVEMAFMSDSDRKALYAKKAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: CATR_ASPNG
Sequence: MRHFWLLPAVAGIAGAQCPYLSGEMSFTQEQDNAGDTIEVTEQPIDNTLYVNDTGSYMTTDFGTPISDQTSLKAGPRGPTLLEDFIFRQKLQRFDHERVPERVVHARGAGAYGTFKSYADWSNVTAADFLSANDKETPMFCRFSTVVGFRGSVDTARDVHGHACRFYTDEGNYDIVGINFAPFFIQDAIQFPDLVHAIKPMPNNEIPQAATAHTSAWDFFSQQSTALHSALWLMSGNGIPRSFRHMNGYGVHSFRFVAANGTSKVVRTPWKSQQGVASLVWDEAQAAAGKNSDYHRQDLYNAMPNGHYPKYELQAQIMDEADMLRFGFDLLDPTKLVPEEVVPYTPLGMMELNANPTNYFAEVEQAGFQPGHVVPGIDFTDDPLLQGRLFSYLDTQLTRHGGPNFEQIPVNRPRKPVHNNNRDGFGQQQIPTNNWAYTPNSMSNGYPMQANQTQGHGFFTAPYRYASGHLVRQTSPTFNDHWSQPAMFWNSLIPAEQQMVVNAIVFENSKVNSPHVRKNVVNQLNMVNNNLAVRVARGLGLDEPSPNPTYYTSNKTSNVGTFGKPLLSIEGLQVGFLASNSHPESIKQGQAMAAQFSAAGVDLNIVTEAYADGVNTTYALSDAIDFDALIIADGVQSLFASPALANQMNSTATSTLYPPARPFQILVDSFRYGKPVAAVGSGSVALKNAGIDSSRSGVYTGSSETTEKIAKEVLEGLYTFRFVDRFALDE
What is the function of this protein?
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase R.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: CCZ1A_ARATH
Sequence: MASMSSGDESLRLCMFDLRRGQTEGQELEKILFFYPADLDFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMVVEKNKETGAIWRIDALRRVLKEVHSLFVMFHGSIRALIEKEPTGGLTRSLLYPFITDYLSTFQIWSLSEDCCCEFFVGKKLQLPTFRETLRERGTVQMLTLARDTAVEVQSLVQVLDSCAGSLRCHSMILFQDLLVSTTLSADDTVDLFTFAVMRLTSKALSSDTSSWSYLRKGPGSSEISSRSNLAPVGSIDSLHSRNGNNMHHVIRPLQNDKWTKGKDGFLITDIWGLETGGSPDSAIPTIWLQQTQERMYLLAYQHKSLTLLLLMPTNAIVNGDLSISAVKQQVIEDASLRILKIEENISRGWGGENAYHIKGYRYLVVDNDTKVSRSSPSGKVTTLAKESLLALNKLREEVDSEKSRAKGQEKDMEICIRAKNNVWVIARVTRGKELYMALEKGSDTLLDTTDAVGRFSNRYCSGAFLMD
What is the function of this protein?
Plays an important role in membrane trafficking through the secretory apparatus.  In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family.  Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form.  The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles.  May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
What are the official names of this protein?
Vacuolar fusion protein CCZ1 homolog A.
What is the protein family that this protein belongs to?
Belongs to the CCZ1 family.
What are the subcellular locations of this protein?
Endosome. Prevacuolar compartment.
Protein: MNHA1_STAA1
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVLGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHS7_ASPFU
Sequence: MGFGQFDSICQKAALPLCSLVGPSSPISGSTGIIPNCYARNIELANTIIFEGAASFVHIIALGMTVIMILHVRSKFTAVGRKEIITFFYIYMALTICSLVIDAGVVPPRSGPFPYFVAVQNGLSSALCTCLLINGFVGFQLYEDGTFLSVWLIRLTSAVMFVVSFLISLLTFKSWGGMSPTNTIALFVVLYILNAISIAIYLVMQLLLVMNTLEDRWPLGHIAFGVIVFICGQVLLYGFSDTICDNVQHYLDGLFFATFCNLLAVMMVYKFWDYITKEDLEFSVGIKPNTWEVKELLPEEDRRTTVYQDSHSEYAGSMYHHRASTYGGHNY
What is the function of this protein?
Chaperone required for the export of the chitin synthase chs3 from the endoplasmic reticulum.
What are the official names of this protein?
Chitin synthase export chaperone.
What is the protein family that this protein belongs to?
Belongs to the CHS7 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LEPA_RHOCS
Sequence: MTDLSRIRNFSIIAHIDHGKSTLADRLIEFCGAIEAREMKAQLLDNMDIERERGITIKAQTVRLNYKAKDGEIYQLNLMDTPGHVDFAYEVSRSLAACEGSILVVDASQGVEAQTLANVYQAIDANHEIVPVLNKIDLPAADVPRVKQQIEDVIGLDASDAVEVSAKSGINIDGVLEAIVTRLPPPKGDAAAPLQALIVDSWYDAYLGVVVLVRVVNGELRTGQKVRFMATGATRELDRVGIFGPKKMLVDRLGPGEMGFVTAAIKDIRDTKVGDTITEEKRLAPTPLPGFKPSIPVVFCGLFPTDAADFEDLRESLGKLALNDASFQFEMESSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLITTAPSVVYRMHMNDGTMKEMHNPADMPDPVKIDRIEEPWIKANIMLPDEYLGGVLQLCTERRGIQKDLTYVGGRAMLVYELPLNEVVFDFYDRLKSISRGYASFDYVLEGYREGDLVKMSILVNNEPVDALAMIVHRTQAEYRGRQLCERLKDLIPRHLFKIPIQAAIGGRVIARETIAALRKDVLAKCYGGDISRKRKLLDKQKEGKKRMRQFGEVEIPQSAFIAALRMGQE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TPS9_SOLLC
Sequence: MAASSADKCRPLANFHPSVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVETCDNSTQKLVLIDAMQRLGVAYHFDNEIETSIQNIFDASSKQNDNDNNLYVVSLRFRLVRQQGHYMSSDVFKQFTNQDGKFKETLTNDVQGLLSLYEASHLRVRNEEILEEALTFTTTHLESIVSNLSNNNNSLKVEVGEALTQPIRMTLPRMGARKYISIYENNDAHHHLLLKFAKLDFNMLQKFHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVLNLTSIIDDTFDAYATFDELVTFNDAIQRWDANAIDSIQPYMRPAYQALLDIYSEMEQVLSKEGKLDRVYYAKNEMKKLVRAYFKETQWLNDCDHIPKYEEQVENAIVSAGYMMISTTCLVGIEEFISHETFEWLMNESVIVRASALIARAMNDIVGHEDEQERGHVASLIECYMKDYGASKQETYIKFLKEVTNAWKDINKQFFRPTEVPMFVLERVLNLTRVADTLYKEKDTYTNAKGKLKNMINSILIESVKI
What is the function of this protein?
Involved in the biosynthesis of germacrene C, one of the most abundant sesquiterpene in the leaf oil of tomato (PubMed:11090225).  Produces mainly germacrene C, but also smaller amounts of germacrene A, B and D when used with farnesyl diphosphate (FPP) as substrate; able to use both (2E,6E)-farnesyl diphosphate ((EE)-FPP) and (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) (PubMed:9482865, PubMed:21818683).  No or low activity with geranylgeranyl diphosphate (GGPP) (PubMed:9482865).  Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, limonene and terpinolene (PubMed:21818683, PubMed:9482865).
What are the official names of this protein?
Sesquiterpene synthase 9, SlTPS9, Terpene synthase 9, Beta-myrcene synthase TPS9, Germacrene C synthase TPS9, Limonene synthase TPS9, Sesquiterpene synthase 1, Terpinolene synthase TPS9.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_TRIL1
Sequence: MSDSKCPVTGKSSRQVAGGGTSNRDWWPNQLNLQILHQQSTKSNPMGEGFNYRQEFTMLDLAAVKKDLVALMTDSQDWWPADWGHYGGLMIRMAWHSAGTYRMGDGRGGAGSGSQRLAPLNSWPDNVNLDKARRLLWPVKQKYGRKISWADLMILAGNCALESMGFKTFGFGGGREDIWEPQEDVYWGGEKEWLATSDKPYSRYSGERDLDNPLAAVQMGLIYINPEGPDGNPDPVASGRDVRETFARMAMNDEETVALVAGGHTFGKCHGAGTADHVGPEPEAAPLEAQGLGWISSYKSGKGGDTISSGIEGAWKPNPTTWDMGYLKVLFKYEWELVKSPAGAHQWLAKDVADEDMVVDAHDPAKKRRPMMTTADLSLRFDPAYEKIARRYLANPDEFADAFARAWFKLTHRDMGPRSRYLGPEVPAEELIWQDPVPAATHELINNSDVADLKVTILATGLSISQLVTTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPGQLAKVLETLAAVQQEFNAAQSGNKRVSLADLIVLGGCAAVEQAARNAGQTVAVPFTPGRTDASQEQTDTASFEVLEPKADGFRNYQKEKYAVSAEELLVDRAQLLTLTAPEMTVLIGGMRVLNANFGNARHGVFTKRPEALTNDFFVNLLDMATIWKATSEDQDLFEGRDRTSGELKWTATRVDLIFGSNSQLRAIAEVYGCEDSQEKFLQDFAAAWDKVMQADRFELV
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: KAD_COLP3
Sequence: MRIVLLGAPGAGKGTQAQFLMAKFGIPQISTGDMLRAAIKAGSELGNKAKAVMDAGQLVSDDLIIGLVKERVAQEDCKAGFLLDGFPRTIPQADAMKESGIVVDHVLEFDVPDEVIVERMAGRRVHSGSGRVYHLVYNPPKVEGKDDVSGDDLSIRPDDEEATVRKRLAIYHEQTKPLVDFYQAEAKSGSCSYLTIDGTQAVEKVNQLLSAQLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARRD4_MOUSE
Sequence: MGGEAGADGPRGRVKSLGLVFEDESKGCYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAWGPSAGARVCIGGGSPAASSEVEYLNLRLSLLEAPAGEGVTLLQPGKHEFPFRFQLPSEPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKRLMLELPLVIGTIPYSGFGRRNSSVASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHVPPYPQPSDCDGEACYSMFACIQEFRFQPPPLYSEVDPHPGDAQETQPVSFIL
What is the function of this protein?
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:27462458).  Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity).  Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458).  May play a role in glucose uptake (By similarity).  Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (By similarity).
What are the official names of this protein?
Arrestin domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Early endosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Note=Also found in extracellular vesicles different from exosomes.
Protein: ECFA1_STRP6
Sequence: MSAIIELKKVTFNYHKDQEKPTLDGVSFHVKQGEWLSIIGHNGSGKSTTIRLIDGLLEPESGSIIVDGDLLTITNVWEIRHKIGMVFQNPDNQFVGATVEDDVAFGLENKGIAHEDIKERVNHALELVGMQNFKEKEPARLSGGQKQRVAIAGAVAMKPKIIILDEATSMLDPKGRLELIKTIKNIRDDYQLTVISITHDLDEVALSDRVLVMKDGQVESTSTPEQLFARGDELLQLGLDIPFTTSVVQMLQEEGYPIDYGYLTEKELENQLCQLISKM
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FDC1_ASPNC
Sequence: MSAQPAHLCFRSFVEALKVDNDLVEINTPIDPNLEAAAITRRVCETNDKAPLFNNLIGMKNGLFRILGAPGSLRKSSADRYGRLARHLALPPTASMREILDKMLSASDMPPIPPTIVPTGPCKENSLDDSEFDLTELPVPLIHKSDGGKYIQTYGMHIVQSPDGTWTNWSIARAMVHDKNHLTGLVIPPQHIWQIHQMWKKEGRSDVPWALAFGVPPAAIMASSMPIPDGVTEAGYVGAMTGSSLELVKCDTNDLYVPATSEIVLEGTLSISETGPEGPFGEMHGYIFPGDTHLGAKYKVNRITYRNNAIMPMSSCGRLTDETHTMIGSLAAAEIRKLCQQNDLPITDAFAPFESQVTWVALRVDTEKLRAMKTTSEGFRKRVGDVVFNHKAGYTIHRLVLVGDDIDVYEGKDVLWAFSTRCRPGMDETLFEDVRGFPLIPYMGHGNGPAHRGGKVVSDALMPTEYTTGRNWEAADFNQSYPEDLKQKVLDNWTKMGFSN
What is the function of this protein?
Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
What are the official names of this protein?
Ferulic acid decarboxylase 1, Phenacrylate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family. UbiD-like/FDC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODD_AZOC5
Sequence: MRFKGLDLNLLVALNALLSEHSVTSAAKSINLSQPAMSAAVQRLRIYFNDDLFTINGRERVFTARAESLAPAVRDILSRIQSTIIKGDLFEADRSERVFRIISSDYSTSIFIRGVISAASTSLPLLRFELISPDDNCHDLLNKSEVDALIMPEIFMSSAHPFVPLFEEKMVCVGCARNHEDRNISSIQEYLSMRHVVAKFGRGMRPSLEEWFMAENGMRRRIDIVVQSFSMIPPVIQGTERIAIMPYRLVEHFSKFMPLKVFALPFPLPRFTECLQWPSIATPDLGNRWLRAYLADHASQMMILDSAEYSGASI
What is the function of this protein?
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins.  NodD is also a negative regulator of its own expression.  Binds flavonoids as inducers.
What are the official names of this protein?
Nodulation protein D.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: C49A1_DROME
Sequence: MSGLRKTSIALMRRSTSSTTILPHSGGVGGAVSPPSSGVGVATEIEKSIAMQRLRTGESSNPKKLNVSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYIPQSPLNFKLTLRDE
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 49a1, CYPXLIXA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MINC_PARXL
Sequence: MSPKKSPFFELRSGSVDTLLFVVKTTDLEAMRAELTRRFEATPEFFANDVVAIDVRRLAGNERVALADIAQLLDSVRMRPVGVVADAQQAWAAESALPLLEARDRRGAAARSADEESANAAAAAPAATAATATPPADLFESVAGTPESGTPATAAAVEPAPAAEPVRLATSSQTMVVDKPLRSGQRIYAKGDLVVLGLVSYGAEVIAEGNIHIYAPLRGRALAGVQGNHDARIFCTCLEPELISIAGIYRTTENPLPADVLGKPVQIWLEEEKLMIEPLRLT
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: CD4_DELLE
Sequence: MDPRTSLRHLFLVLQLVMLPAGTQGKKVVLGKAGELAELPCKASQNKSLFFSWKNSYQTKILGRHGYFWHKGASNLHSRVESKINLWDQGSFPLVIKDLEVPDSGTYICEVEDKKIEVELQVFRLTASSDTRLLLGQSLTLTLEGPSGSNPSVQWKGPGNKRKNEAKSLSLPQVGLQDSGTWTCTVSQAQQTLVFNKHILVLAFQEVSSTVYAKEGEQMNFSFPLTFGDENLSGELSWLQAKGNSSPESWITFKLNNGKVTVGKARKDLKLRMSKALPLHLTLPQALPQYAGSGNLTLNLTKGKLYQEVNLVVMRVTKSPNSLTCEVLGPTSPRLILSLKKENQSMRVSDQQKLVTVLGPEAGMWQCLLSDKGKVLLESKVKILPPVLAHAWPKLLAVVLGGITSLLLLAGFCIFSAKCWHRRRRAERTSQIKRLLSEKKTCHCSHRLQKTCSLT
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.