PharMolix/UniProtQA huggingface dataset:
Protein: NRDI_CITK8
Sequence: MSQLVYFSSSSENTHRFMQRLGLPAIRIPLNERERIRVDEPYILVVPSYGGGGTAGAVPRQVIRFLNDEHNRALIRGVIASGNRNFGEAYGRAGEVISQKCGVPWLYRFELMGTQSDIDNVRKGVSEFWQRQPQNV
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: IF4EH_MIMIV
Sequence: MDSNNTEFKDNYQHIPDDIPLTNIKLPNEWVLYLYDKQLFKKMANRPNFQAKPHKALCTISTVNDLLYIMELMKVNNDPKIKSVETDGKINLDANDYIIMRKGIEPIWEDPRNSNGGTFTVKMDHSKGYDVWKIFIQYILGETLTSEISDMKSINGITVSYISDSYNFQNPASKNTLGNTLGNSLGNSLGNGLGNSFTYIKIWDGKPDRTRDQFVSMLPATIIDKIKSDSLMYSQNSKKKHFNEKNIIGKLNSGRKPSNTRGGFSSFGNKRY
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E homolog, eIF-4E, eIF4E, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: NU2M_DOBMI
Sequence: MNPAIFTTIILTMILGTMIVTTSSHWLTVWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAITINLVYSGQWSVTKPLTPMASITMTLAMAMKLGLSPFHFWVPEVTQGTQLSSGLILLTWQKLAPMSILYQISPTINLELLLMMAILSIAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPAMTLLNLXVYILLTTTXFMMLMLNSSTTTLSLSHTWNKTPLLATTILLIMLSLGGLPPLSGFXPKWMIIQEMTKNDSIIMPTIMAMAALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFNSTKPMTYISPLIILSTLXLPLSPMLTLLE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DNAA_STRT1
Sequence: MTEKEHFFWNKLLELAKEELTQATFDYYVLDTKLIKIQDNVATILLEEVKKLFWEKNMQSFILMTGFEVYNSEIKVEYVFDEALVSETKPTLANNDFSNKREQQTPDLPTLNSDLNSKYTFDNFIQGDENRWSVAASLAVADSPGATYNPLFIYGGPGLGKTHLLNAIGNKVLHDNPQARIKYITAENFINEFVLHIRLDKMDELKLKYRHLDVLLIDDIQSLAKKSTQATQEEFFNTFNVLHDNNKQIVLTSDRNPDQLNEMEERLVTRFKWGLTVNITPPDFETRVAILTNKIMDYDYHFPPETIEYLAGQFDSNVRDLEGALKDISLVANVRQLDTITVEVAAEAIRARKIDGPKLTLIPIEDIQSEVGKFYNVTVKEIKATKRTQNIVLARQVAMYLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMLAQDDSLRIEIDTIKNKIK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FES1_ASPTN
Sequence: MDANMNKILKWSIQNSTNASSDQNAAADATSRGLTPEMMATLFGGPSDADLMKASMEALRSDEVDLENKLVAFDNFEQLIESIDNANNLEPLGLWTPLVELLRHEEADMRRMAAWCVGTAVQNNEKAQDKLVVLNALPTLVAMSTSDPNPAARKKAVYALSSAVRNYQPAMDEVAKHLPEGYPRGEKIDAADMDAVDGIMDKLRAHPVESSA
What is the function of this protein?
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP.  Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
What are the official names of this protein?
Hsp70 nucleotide exchange factor fes1.
What is the protein family that this protein belongs to?
Belongs to the FES1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_SHIF8
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQVVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_ALIF1
Sequence: MSITNEQILDAVAEMSVMQVVELIEAMEEKFGVTAAAAVVAGGAAGGDAAEEQSEFDVILTSAGANKVAVIKAVRGATGLGLKEAKGLVDSAPAPLKEGVDKAEAEALKAQLEEAGASVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TRAB4_ECOLX
Sequence: MNKVQIGAPRTSASPGVIMKPEGSVKIAVMNGSRQVDQVVNGEWLTMKVLPEAGLPKGIHQLSDAKDASKNVHPHKHVGQVLHDDGRNVYQFSEGGIVKHSRGIFEKPPVVGKNYEIAYSRGQGKVIGEVSQEQAAKAEQKRSRSI
What are the official names of this protein?
Protein TraB.
Protein: APT_GEOTN
Sequence: MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDLLATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLEGYDILTLMQF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2HP_PROMU
Sequence: MRTLWIMAVLLLGVEGSVIELGKMVFQETGKNPVKNYGLYGCNCGVGKRGKPVDATDSCCFVHRCCYKKVTGCDPKKDRYSYSWENKAIVCGEKNPPCLKQVCECDKAVAICLRENLGTYDKKHRVTMKFLCKAPESC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity.  Exhibits potent myotoxicity causing myonecrosis and edema in the gastrocnemius muscle of mice (PubMed:16793192).  Is also able to stimulate the release of IL12 (IL12A-IL12B), TNF-alpha (TNF), IL6 and IL1-beta (IL1B) from human monocytes, and induce IL2, TNFalpha and IL6 release from T-cells (PubMed:16793192).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog promutoxin, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. R49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPA_MOOTA
Sequence: MQWGRILTAMVTPFTADGKLDLDGARRLAAYLVDHGSDGLVVAGTTGESPTLTHEEKIALFREVKKAVGDRAAVIAGTGTNSTAASIELSREAEALGVDGLMLVVPYYNRPSQEGLYQHFKAIAAATTLPIILYNIPSRTGRNMDAATTLRLAEIKNIKAVKEASGDLDQATAILRQAPADFLVYSGDDSLTLPLMAVGGYGIISVVAHVAGEKMQAMVRAFTAGDVQGAAALHRELFPLFKALFITSNPVPVKEALQMLGLPAGPVRLPLVGATREEKEKIAAALKETGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_SHEB8
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSHLSLYDIAPVTPGVAVDLSHIPTAVEIKGFAGEDPTPALVGADVVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVAATCPTALVGIITNPVNTTVAIAAEVMKKAGVYDKNRLFGITTLDVIRSETFIAELKGLNVADVKVNVIGGHSGVTILPLLSQVEGVTFTDEEVASLTTRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLSLVRGLQGEANIVECAYVDGGSEHAEFFAQPVLLGKNGIEKVLPYGEVSAFEANARDSMLDTLKGDIKLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: PYRB_SODGM
Sequence: MVNPLYQKHIISINDLSREELEMVLTSAAALKARPQPELLKHKVIASCFFEASTRTRLSFETAIHRLGASVVGFPDADNTSLGKKGETLADTISVISTYVDAIVMRHSQEGAARLATEFSGQVPILNAGDGANQHPTQTLLDLFTIQETQGRLDHISVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPKALAMPAHILHMLEEKGIAYSLHASIEDVIPELDILYMTRVQKERLDPSEYANVKAQFVLHAGDLLQARANLKVLHPLPRVDEIAIEVDHTPYAYYFQQAGNGIFARQALLAAVLGHNPDQPTS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ATPD_SULAA
Sequence: MKVDKKFLKKVVKGMIKVLGNDEEKLSNTSKALDILSLLYKSNSNFRNIILSPTVSLEEKEKAVSKILDVLNLPQEVKPFIFLAVKENKGNIIKELNKAFRFEVEKFFATVQGEVITAHPIDEDLLNQIKTVLESKIGKKIEFTVKEDKSLIGGAVIKAGSYILDTSVRNYLKQLERSLTRF
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZIPA_KLEP7
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSRDDESENDDFDDNVEGVGEVRVHPVTHAPHGAHGEHEAPRQSPQHQYQPPYERQMQQPARPEEPVRQPPQPPRQAPVPPQQQPAPHAAPQPGWQQPQPAQPPVQPQHQPQPVVQQPVAPQPVTPTVAQPQPAAPQQPAPQPVAASQPAVAEPQPVEPQQPAAPQPKERKETVIVMNVAAHHGAQLNGEVLINSIQQAGFKFGEMNIFHRHLSPDGSGPVLFSLANMVKPGTFNPDSMADMMTPGVTIFMQVPSYGDELQNFKLMLQSAQYIADEVGGVVLDDQRRMMTPQKLREYQDRIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: STYK1_HUMAN
Sequence: MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML
What is the function of this protein?
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines.  When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs.  May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase STYK1, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACPS_BACC2
Sequence: MIIGIGIDIIELNRIEKMLDGKLKFMERILTKNERNVAMELKGSRLTEFVAGRFAAKEAYSKAVGTGIGKEVSFLDIEVKNDERGKPILITSTEYVVHLSISHSKEFAVAQVVLESSSR
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_HYDCU
Sequence: MTLLAIGIEYQGTAYCGWQHQKHCDSVQQQLEKALSYIADEPIGLNCAGRTDTGVHAIGQIAHFETNASRPDKAWIQGVNTQLPNDIRVTWVKPMPEDFHARFSAVARQYRYVIFNRPVHSAILANRVTWENRPLDVKKMHAAAQDLLGENDFSSFRAAGCQASHANRNVQYLQVSRQGNFVFVDIQANAFLHHMVRNIVGTLLEVGRLDKPVEWVSELLKKQDRTQAGMTAPAAGLYFVNALYPESFELPRVVLDELLWQA
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CCA_TOLAT
Sequence: MQIYLVGGAVRDTLLGLPVTERDYVVVGSEAQTLLDLGYQPVGRDFPVFLHPQTKEEYALARIERKQGKGYTGFACYAAPDVTLEQDLLRRDLTINAIAQDQDGQLYDPYGGISDLNNRVLRHISPAFSEDPLRVLRVARFAARFHHLGFYIAPETLALMRKLSRSGELNHLTPERIWKEIEKVLSGRNPQIFFEILHDCEALNVLLPEVDALFGIPARPDWHPEVDTGIHVMMALREASQRSEQLAVRFATLCHDLGKAQTPAHILPSHHGHGERGTPLIRELCKRLKVPNDCRDLAILVSELHSLVHTALQLRPATMLKLFDRLDVWRKPERLSQLLLCCQADFYGRQGFAEREYPEPEYVQQAYDAAVAVAVKPIVEAGYTGEAIRLQLSRRRIFAIRDVHCRWNDK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: EIF3B_DROME
Sequence: MAKKKSEEHSGTDANDSDYQEEPNFDDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKLVINKLFSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKYENIPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAETAPNCVQVGFWQNVLPEPFELETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTYGPTPTGQKIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKFVARMGENSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIPKKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFLGMFYNFEIFHMREKEIPVDSVEIRELILAFAWEPVGNKFSIIHGETNSSNVSFYEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMANLTMGTFEFVDSTNDYIITASPDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEEKQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQKSRRIMLRGHVDTDNLETDEVDEEIVEFLVKEEVTLLE
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit B, eIF3b, Eukaryotic translation initiation factor 3 subunit 9.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSBA_SODGM
Sequence: MLNDKDLSTWQTFRRLWPMISPFKTGLIVAAIALILNAASDTFMLSLLKPLLDDGFGKANSNILVWMPLVVIGLMVLRGVSGFVSSYCVSWVSGKVIMNMRRRLFNHMMDMPVSFFDQQSTGTLLSRITYDSEQVASSSSGALITVIREGASIIGLFAMMFYYSWQLSLILVVIAPVVSFAIRQVSKRFRQISKRMQNTMGQVTTSAEQMLKGHKEVLIFGGQKVENERFNSVSNRMRQQGMKMVAASSVSDPLIQFIASLALAFVLYAASFPSVMETLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFSILDMETEKDEGTVEVERVKGDIAFDHVTFSYPGKETPSLHDISLSIPTGHTVALVGRSGSGKSTIANLLTRFYDIQQGQILLDGTDLRAYKLASLRNQVALVSQNVHLFNDTIANNIAYARKATYSRKQIENAARMAYAMDFIEKMDQGLDTVIGENGVLLSGGQRQRIAIARALLRDCPILILDEATSALDTESERAIQKALDALQKNRTSLVIAHRLSTIEKADEILVVVEGRIVERGNHEELMSRQGVYAQLHQLQFGQ
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FEMX_STAHJ
Sequence: MEKMNITNQEHDAFVKAHPNGDLLQLTKWAETKRLTGWYSKRVAVGEDGEIKGVGQLLFKKIPKLPFTLCYVSRGFVTDYSDKAALEQLLEETKKVAKAEKAYAIKIDPDVEVDKGIDALKNLNALGFKHKGFKEGLSKDYIQPRMTMITPIDKSDEEIFQSFERRNRSKVRLSLKRGTKVERSNREGLKNFAELMKITGERDGFLTRDLSYFQNIYDSLHEDGDAELFLVKLEPKPVLDDIDNELKELESEKTQLQNKYERKQVKKTKNKLNDVEAKIQKSIERKDDMTDLLAKHPNGIYLSGALLMFAGSKSYYLYGASSNDYRDFLPNHHMQYEMMKFAREHGAKTYDFGGTDNNPDKDSEHYGLWAFKRVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKGK
What is the function of this protein?
Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor.
What are the official names of this protein?
Lipid II:glycine glycyltransferase, Factor essential for expression of methicillin resistance X.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR321_MIMIV
Sequence: MLIVLININNKYYCYNILIMEPKEIDSTDNNLVDEKVDNNNNSVIESNSGSDSESDYDTDSFTDDDSDDDFEKQQLERLENAGRDIDTFKNWFKNKTDDSNVYNVFESTFSPEFRSQLYEYINEFFNNNDIVTDQLLAYWKILIKNIMRSNRKYQVIASKINIDENTYDSNLKLFKEKSMFRCFMDEEPICYFKENGNNYYVS
What are the official names of this protein?
Uncharacterized protein R321.
Protein: Y1603_CORJK
Sequence: MSTPTPPSSGRPKQPFPSSPGSSRRSKILGILVAIIAIAIFIVPVVVSTYTDFAWFRSVDYQGVFMNVIVTRLVLFVVFGLIGALISWLAAFLAYRARPDEIESLGTSSPLAEYRPLIRRNMRPFLVGIPLFVGVITGMIVQSNWRSVLLFLNGSNFGVHDPQFDKDLGFYAFNLPFLQMLVSTFSVLLILAFVINGIGHYLLGSITTGNPRVGEKASISTNARRQLAVIAGVWMLLKAVGYWFDRYGLLTRSHETFTGASYTDINAVLPAQIVLLVISIFVAAMFFVTIVLRDLRIPALAVALMVGSSLTVGLAWPAMLEQFSVNPNRAEKEREYIARNIEATRYAYGIGDDKVTYDRDWGASGDAASKEQKKAVADDSATLSNVRLLDPEVLTPTFTQQQQLRNFYGFPDELAIDRYEVDGKMRDFVVAARELNPNTLDGNQNDWINRHTVYTHGNGFVAAPSRKVDEVARDVGSARGGYPVYTVADLQSMQSGKQGGELKLDVKQPRIYFGPVIASSNQNNSDYAIVGNTEGEPLEYDTDASNYTYTGTGGVDVSNYFNRLMFSAHFESMNMLLTDRIGEGSKILYERDPRERVHKVAPWLTTDSKTYPIVIDGRVKWVVDGYTTLNNLPYSERIGLTDSTADAINPDGVSETQVVDNEVGYIRNSVKAVVDAYDGSVDLYAFDEADPVLKAWRGAFPGVVKPRSEISKELEDHLRYPEDMFKVQRELIAKYHVSDPGVFFQNDSFWSVPTDPTAPQDRQDNAQPPYYVVAADPETNKPSFQLITPFRGLRREFLAAHMSVGSDPDNYGKINVRVLPTGTQTLGPNQAQDTMMSSDEIARERTLLKGTNDLTNGNLLTLPVGDGQILYVEPVYSQRSGQDSAFPKLLRVLVSYNGQVGYAPTIAEALDQVGIKTSSTTDIQEIDGSVVDPTKDGGSGNKGDKGKDADKDKKSKDEQSSDAKGAAGKSDDKGTDTAPEQRVRDAMDKVNKTRESGTFEEFGKALDELDKAVQDLQSER
What are the official names of this protein?
UPF0182 protein jk1603.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MREG_MOUSE
Sequence: MGLRRWLRSACCCCPCRCLEEPARPEKEPLVSGNNPYSSFGATLERDDEKNLWSMPHDVSHTEADDDRILYNLIVIRNQQTKDSEEWQRLNYDIYTLRQIRREVRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETSIFPASWELSERYLLVVDRLIALDAAEDFFKIASQMYPKKPGVPCLVDGQRKLHCLPFPSP
What is the function of this protein?
Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22940130, PubMed:22275436, PubMed:30174147).  Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:3410303, PubMed:22753477).  Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22940130, PubMed:22275436).  Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147).  Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147).  Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024).  Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024).  Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024).  May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable).
What are the official names of this protein?
Melanoregulin, Dilute suppressor protein, Whn-dependent transcript 2.
What is the protein family that this protein belongs to?
Belongs to the melanoregulin family.
Protein: PYRF_STAAE
Sequence: MKDLPIIALDFESKEKVNQFLDLFDESLFVKVGMELFYQEGPQLINEIKERGHDVFLDLKLHDIPNTVGKAMEGLAKLNVDLVNVHAAGGVKMMSEAIKGLRKHNQDTKIIAVTQLTSTTEDMLRHEQNIQTSIEEAVLNYAKLANAAGLDGVVCSPLESRMLTEKLGTSFLKVTPGIRPKGASQNDQHRITTPEEARQLGSTHIVVGRPITQSDNPVESYHKIKESWLV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.