PharMolix/UniProtQA huggingface dataset:
Protein: RL33_RICAE
Sequence: MAKKNKNVLVRLVSTAGTGVFWVKKRNPKTQTEKLSFRKYDKVVRKHVLFKEEKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PURL_ANAD2
Sequence: MTEPITPEIVAQHGLKPEEYQRILEHLGRTPTLTELGVFSVMWSEHCSYKSSRVHLKTFPTSGPRVLQGPGENAGVVDLGDGLAAAFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIASLNALRFGDPSHPRTAYLLEGVVAGIGGYGNCMGVPTVGGEVAFHPSYNGNCLVNAFTLGILPADKIFRGTAAGVGNPVMYVGAKTGRDGIHGATMASAEFDASTEEKRPTVQVGDPFMEKLLLEACLELFQTDAVVGIQDMGAAGLTSSSVEMAGRGGNGLDLFLDQVPLREEGMTPYEILLSESQERMLLVAAEGKEELVRSICEKWDLDVAVIGRVTASGRWRAHWRGAVVADLPVDPLTEGAPKYHRPMAPHPALPALHAFDAAALPEPADLGAALLRLLARPTIASKEWVYRQYDHMVRLVGAVRPGGDAAVVRLAVSHDAHAHKGIALSVGVNGRFCFLDPYLGAMHAVAECARNIACVGGEPIAITDCLNFGNPEKPEIMWQFAECVRGIGDACRAFGTPVVSGNVSLYNETEGQGILPTPTVGMVGLVEPVERTCHSTFRDAGDVIALVGSLQGEVGGSEYLSAEHGKEAGRPPALDLAREKAVQETVRRAVRAGLLSSAHDCSEGGLAVALAESCMMHEVPADGSKPAWIGCAVRIPFPVRKDFVLFGEDASRILVSLPKENAARFVDLAQQCGAPVIRLGAVGGDRLEIQGALSVPVEDLARAWRDGIPAVLRRDAAHAGTTAPA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLA1_BACCE
Sequence: MRINTNINSM
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
What are the official names of this protein?
Flagellin.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: SSRP_PECCP
Sequence: MTKKKAYKPGSATIAQNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANLSDSYVTFMNGEAYLFGATITPLNVASSHVVCDPIRTRKLLLNKRELESLFGRVSREGYTVVALSMYWKNAWSKVKIGVAKGKKDHDKRDDIKEREWKLDKARIMKNANR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: HUTG_SALDC
Sequence: MTQWYPASPALWQGRDDSIEAPDARRLFQTVTRSETFSPENWQQKIALMGFACDEGVKRNAGRPGAAGAPDALRKALANMASHQGHERLVDLGNWVAPTPDLEGAQQALRDAVSRCLRAGMRTLVLGGGHETAFGHGAGVLDAFAQESVGIINLDAHLDLRQTDRATSGTPFRQLAQLCDAQSRAFHYACFGVSRAANTQALWREAQWRNVTVVEDLDCHDALAQMTQFIDKVDKIYLTIDLDVLPVWEMPAVSAPAALGVPLIQVLRLIEPVCRSGKLQAADLVEFNPRFDEDGAAARVAARLGWQIAHWWR
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: SAU39_ORYSJ
Sequence: MPLQTIHKLKHQYTHNKSSSHQKKHTMINPKRLVHLAKKWQHMAALGRRRLTITGATKEGNLRCSSAIADKGHCIIYTADGERFGVPLTYLSTTVFGELLRLSEDEFGFTGEEKITLPCEAAVMEYVMCLLRRKPSEEVEQAVVSSVVMPCNYKSSTSMVSVNLSQSLAIF
What is the function of this protein?
Involved in the negative regulation of organ growth.  May act as a negative regulator of auxin synthesis and transport.
What are the official names of this protein?
Auxin-responsive protein SAUR36, Protein SMALL AUXIN UP RNA 36.
What is the protein family that this protein belongs to?
Belongs to the ARG7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_CHLPM
Sequence: MRKVKPARKLGRTAAHRKATLSSLSTQLILHKRIETTEAKAKETRKVVEKIITKARKGTVHAQREIFKDIRDKEAIKTLFEEIVGKVGTRNGGYTRVIKLCPRFGDAAKMAVIELVDFAEAPAAAPKAARQDRSKRVKGSRKTEASAAKAAPAAQAAPELPAESDAPAAEAAPTEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RNP4_PYRHO
Sequence: MVDIVKRRDWEKKEKKKIAIERIDTLFTLAERVARYSPDLAKRYVELALEIQKKAKVKIPRKWKRRYCKRCHTFLIPGVNARVRLRTKRMPHVVITCLECGYIMRYPYLREVKQKRKKAT
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.  Binds RNase P RNA.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_XYLFM
Sequence: MKPFTQHTGLVCPLDRVNVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDAGQPGQDNSKRPINSDFVLNLPRYRGASVLLARDNFGCGSSREHAAWALDEYGFRTVIAPSFADIFFNNSFKNGLLPLVLNKVEVDALFAQCQVTEGYTLTVDLAAQQVITPDGTTYAFQIDTFRKHCLLNGLDDIGLTLQYAEAIRAFEATHRIRQPWLFAPLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: YONI_SCHPO
Sequence: MLCAARKCLNKTFISVRLNAFSCLAELNFRHTWYCSKKETPYQLERLQEEDIEETFICGKGPGGQKINKTSIVAQVKHIPTGIIVRSQDTRSREQNRCIARKRLTEKVDEFKHGNDSLLARKVQRIVKKKKQREKKSKRKYGNKIDDQDSSLNNNEAKQDVI
What are the official names of this protein?
Uncharacterized peptide chain release factor-like protein C1105.18c, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: S35A3_MOUSE
Sequence: MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGVYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVALQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA
What is the function of this protein?
Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:31118275).  May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (By similarity).  However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transporter, Golgi UDP-GlcNAc transporter, Solute carrier family 35 member A3.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: LCL2_PODAN
Sequence: MRSLSLILLALATMLTPISAQFGFFDQMFGGGGGGEQEQHHGHGHGGHQRQQQNAPSDGAGYRAQYARLHCDNYLCPDTLACVHFPHHCPCPWPAHEEKVELAEGQRICVSHGGFKAGEAARKVELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: BIOB_CORGL
Sequence: MTIPGTILDTARTQVLEQGIGLNQQQLMEVLTLPEEQIPDLMELAHQVRLKWCGEEIEVEGIISLKTGGCPEDCHFCSQSGLFESPVRSVWLDIPNLVEAAKQTAKTGATEFCIVAAVKGPDERLMTQLEEAVLAIHSEVEIEVAASIGTLNKEQVDRLAAAGVHRYNHNLETARSYFPEVVTTHTWEERRETLRLVAEAGMEVCSGGILGMGETLEQRAEFAVQLAELDPHEVPMNFLDPRPGTPFADRELMDSRDALRSIGAFRLAMPHTMLRFAGGRELTLGDKGSEQALLGGINAMIVGNYLTTLGRPMEDDLDMMDRLQLPIKVLNKVI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: SYP_STRPS
Sequence: MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLPLANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKSDFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDAYSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSARTALDRWVVLDKSVVSFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATNEYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVGNDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVRNAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFKLGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRYAWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKFSDSDLIGLPIRITVGKKATDGIVEVKIKATGDTIEVHADNVLETLEILSKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAEA_GIBM7
Sequence: MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLAPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRRVRVTPQEHRQMLEATGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ
What is the function of this protein?
Methyltransferase that performs automethylation (By similarity).  No other methyl-accepting substrate has been identified yet (By similarity).  Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:22713715).  Controls the expression of the bikaverin, fumonisins, fusaric acid, and fusarins gene clusters; as well as two clusters for which the corresponding secondary metabolite is unknown (PubMed:22713715).
What are the official names of this protein?
Secondary metabolism regulator LAE1, Methyltransferase LAE1, Velvet complex subunit LAE1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IHFB_HAES1
Sequence: MTKSELIENLASTNPNVPLKDIENAVKDILEQLSQALENGERIEIRGFGSFSLHFRQSRIGRNPKTGEKVDLSAKYVPHFKAGKELKERVNIYS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: BAICD_CLOSV
Sequence: MSYEALFSPFKVRGLELKNRIVLPGMNTKMAKNKHDIGEDMIAYHVARAKAGCALNIFECVALCPAPHAYMYMGLYTDHHVEQLKKLTDAVHEAGGKMGIQLWHGGFSPQMFFDETNTLETPDTLTVERIHEIVEEFGRGARMAVQAGFDAVEFHAAHSYLPHEFLSPGMNKRTDEYGGSFENRCRFCYEVVQAIRSNIPDDMPFFMRADCIDELMEQTMTEEEIVTFINKCAELGVDVADLSRGNATSFATVYEVPPFNLAHGFNIENIYNIKKQINIPVMGVGRINTGEMANKVIEEGKFDLVGIGRAQLADPNWITKVREGKEDLIRHCIGCDQGCYDAVINPKMKHITCTHNPGLCLEYQGMPKTDAPKKVMIVGGGMAGMIAAEVLKTRGHNPVIFEASDKLAGQFRLAGVAPMKQDWADVAEWEAKEVERLGIEVRLNTEVTAETIKEFNPDNVIIAVGSTYALPEIPGIDSPSVYSQYQVLKGEVNPTGRVAVIGCGLVGTEVAELLASRGAQVIAIERKGVGTGLSMLRRMFMNPEFKYYKIAKMSGTNVTALEQGKVHYIMTDKKTKEVTQGVLECDATVICTGITARPSDGLKARCEELGIPVEVIGDAAGARDCTIATREGYDAGMAI
What is the function of this protein?
Stereo-specific NAD(H)-dependent 3-oxo-delta4-cholenoic acid oxidoreductase involved in bile acid 7alpha-dehydroxylation.
What are the official names of this protein?
3-oxocholoyl-CoA 4-desaturase, Bile acid-inducible operon protein C, Bile acid-inducible operon protein CD, Bile acid-inducible operon protein D.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: Y085_AFV2P
Sequence: MSNYEILDKIRERIEKEFIMARQSRIDVVLMPMNEYSGYFYTIYTVEYTDVSNEFSSVMLTQGEYIILKNSVLVKIGDKVKQLEL
What are the official names of this protein?
Uncharacterized protein ORF85.
Protein: CYB_GALSE
Sequence: MTNIRKQHPLAKMINHSFIDLPAPSNISSWWNFGSLLGLCLMIQIITGLFLAMHYTSDTSTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFMHIGRGLYYGSFTFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTGLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMIHLLFLHETGSNNPSGISSDSDKIPFHPYYTIKDLLGVILLLVSLFSLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVSSILILALIPHLHTAKQQSMMFRPLSQCLYWMLVADLFTLTWIGGQPVENPFITIGQTASIIYFLIILILMPLTNLLENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL4_ALCBS
Sequence: MNLNTASGGTVTVSEVAFGKDFNEPLVHQVVTAFLAGARQGSKAQKNRSDVSGGGRKPWRQKGTGRARAGTIRSPIWRGGGKTFAAVPRDHSQKVNRKMYRGALQCIMSELVRQERLVVVDEFTVDSPKTKAVAAKLKGMELTSVLIVTDNVDENLFMASRNLPKVDVRDSQGVDPVSLIAFEKVLITVPALKKLEEALA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: YIDE_SALEP
Sequence: MSDIALTVSVLALVAVVGLWIGNIKVRGVGFGIGGVLFGGIIVGHFVDQAGVTLSGDMLHFIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIMGGLVTAILHKIFAIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPVDLVDQMGMSYAMAYPFGICGILLTMWLMRLIFRVNVEAEAQKHESSLANGHSLIQTMNIRVENPNLNNMAIQDVPILNSDKIICSRLKRDDTLMVPSPGTIIQAGDLLHLVGQPTDLHNAQLVIGKEVDTSLSTRGTDLRVERVVVTNEKVLGKRIRDLHFKERYDVVISRLNRAGVELVASSDASLQFGDILNLVGRPASIDAVANVVGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFVPGFPVALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLTQGEGLSWIGYGIFITAIPLITVGLLARIFAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPLVMFLRIITPQLLAVIFWGMG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AKSA_METKA
Sequence: MQSPYVREAVREMDLPDEVIVYDTTLRDGEQTPGVSFTPEQKLEIAHLLDELGVQQIEAGFPVVSEGERDAVRRIAHEGLNADILCLARTLRGDVDAALDCDVDGVITFIATSELHLKHKLRMSREEVLERIADTVEYAKDHGLWVAFSAEDGTRTEFEFLERVYRTAEECGADRVHATDTVGVMIPAAMRLFVAKIREVVDLPIGVHCHDDFGMAVANSLAAVEAGAQAISTTVNGIGERAGNAALEEVIMALKELYGIDPGFNTEVLAELSRKVSEYSGIDVPPNKAVVGENAFRHESGIHVAAVLEEPRTYEPIDPKEVGMNRKIVLGKHTGRKAVVAKLEELGVEPEEEIVEEVLKRIKALGDRRVRVTDSKLEEIVRNVLESRGDRDDPGSR
What is the function of this protein?
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form (R)-homocitrate.  Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate.  These reactions are part of the biosynthesis pathway of coenzyme B and biotin.
What are the official names of this protein?
Homocitrate synthase AksA, (R)-homo(2)citrate synthase, (R)-homo(3)citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: COS1_YEAST
Sequence: MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEVTENTPSSDPHDWEVVAANLNSYLYENKAWNTKYFFFNAMVCQEAFRTTLLEPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNSEKSWSPVGLEDAKLPKEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTFYLGWILFMLVQGFQNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWKNEEFFFDGIDCEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA
What are the official names of this protein?
Protein COS1.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SAT3_STACB
Sequence: MSEALIGGGAKKVYILSRRRDVLESAAAKHEGILIPIQCDVTSKASLQSAVDIVTKDSGYVNLLIANSGTLGPTNRLDHDLSIHELRKNVFDNVSFEDFNNTLSVNTTGAYFTMLAFLELLDAGNKNALKGGFGGPSTEGGAPSIQSQVIFTSSLGAYSRDRLSPPAYSASKSALSHLAKHASTNLAKYGIRVNVLAPGLFPSEIATLMTANRDPATENLGDRMFIPARKFGGAEEMGGTVLYLASRAGSYCNGLILVNDGGRLSVMLSEY
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the satratoxin SC1 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings (PubMed:25015739).  Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton (PubMed:25015739).  SC1 encodes 10 proteins, SAT1 to SAT10 (PubMed:25015739).  The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding (PubMed:25015739).  The putative short-chain reductase SAT3 may assist the PKS in some capacity (PubMed:25015739).  SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase (PubMed:25015739).  SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity (PubMed:25015739).  The probable transcription factor SAT9 may regulate the expression of the SC1 cluster (PubMed:25015739).  SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13 (PubMed:25015739).  SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases (PubMed:25015739).  The SC2 cluster may be regulated by the transcription factor SAT15 (PubMed:25015739).  SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21 (PubMed:25015739).  SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites (PubMed:25015739).  The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression (PubMed:25015739).
What are the official names of this protein?
Short-chain dehydrogenase/reductase SAT3, Satratoxin biosynthesis SC1 cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NADE_EXISA
Sequence: MQQHIIESTHVKPTINPKEEIRQRIDFLKAYVKRAGAKGLVLGISGGQDSSLAGKLCQLAMEELREETGDEYTFYAIRLPYGEQHDEHDAQLALEFIRPDKSFTVNIKPAVDASVEAFHRATGLELSDFHKGNTKARERMKAQYDIAATFGALVVGTDHAAEYVTGFYTKHGDGACDLTPLTGLNKRQGKALLHELEAHERVIYKVPTADLEDGRPGLPDEVALGMTYDQLDDYLEGKTIDPTIAERIETIFKRSRHKHHMPASLYDEWWQ
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: ISPD_CLOAB
Sequence: MNCAIIMAAGRGSRMKVNKNKQFILIQGKPILAYTIDKFQRSPLIDEIIIVAAESEINFCMQEIVYKYKFNKVKNIVSGGSERQQSVMNGLKAVKSANIVLIHDGARPFVDNKIIENGIKYAEKYGGAACGVQPKDTIKIKSEDGFSEKTIDRSKLFCVQTPQCFKYDSILKAHINAEKEGILATDDTMIFEMSGNKVYLYDGSYENLKITTPDDLYAAETLLKKNSIQ
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PCKA_BRUME
Sequence: MKETGIHNKAASISTSGLKELSAVFYNLGPARLYEETIRRGEAELSAQGALVARTGQHTGRSPKDKFVVRDANTEDHVWWDNNKPMTPEAFELLYADFIEHAKGRELFVQDLIGGADADNKINARVITEYAWHSLFIRNLLIRPSQEALASYVPEMTIIDLPSFKADPERYGVRTETVIAVDLTRKIVLIGGTSYAGEMKKSVFTALNYILPAKGVMPMHCSANEGPNGDTAVFFGLSGTGKTTLSADPTRTLIGDDEHGWGEHGVFNFEGGCYAKTIRLSAEAEPEIYATTQRFGTVLENVVLDENRQPDFDDGSLTENTRCAYPLDFIPNASKSGKGGQPKNIIMLTADAFGVMPPIAKLTPAQAMYHFLSGYTAKVAATEKGVTEPEATFSTCFGAPFMPRHPSEYGNLLRKLIAEHKVDCWLVNTGWTGGAYGVGKRMPIKATRALLAAALDGSLNNAEFRIDPNFGFAVPVEVPGVESSILDPRSTWADKVAYDAQAKKLVDMFVSNFEKFESHVDHEVKDAAPAIRMAAE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.