PharMolix/UniProtQA huggingface dataset:
Protein: GPDA_XYLFM
Sequence: MIDSKQKIAVLGAGSWGTALAALVARHDYPTILWGRDVRVIQSIDIQHQNFRYLPSIMLPQTLRATTDLAAAVSGADWILVAVPSYAFTETLCRLAPLLSIGVGVAWATKGFEPGSGRFLHEVAREILGGDVPLAVVTGPSFAKEVTLGLPTAVTVHGEDVCFTQMVANAMHGPMFRAYTGNDVIGAELGGAMKNVLAVAIGVADGMQLGMNARAGLITRGLNEMLRLSAVIGARPETLMGLAGLGDLVLTCTGDLSRNRRLGFALGRGQSLSDAIREIGQVIESVQTSDEVMRQAEQNGVELPISEAVRAVLREEITPYAGMKALLAREQKPEYLDILFKANCSL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFN_NOSS1
Sequence: MAIVTLPNKSVAVNPLKQSQALGASLAFLGLKGMIPLFHGSQGCTAFAKVVLVRHFREAIPLATTAMTEVTTILGGEDNIEQAILTLVEKSSPEIIGLCSTGLTETRGDDIERFLKDIRDRHPEISHLPIVFAPTPDFKGALQDGFAAAVESIVQEIPQPGTTRSEQVTILAGSAFTPGDLQEIKEIVTAFGLVPIFVPDIGASLDGHLDEEYSSVTTSGTTVKQLQEVGCSAFTIALGESMRGAARILEDRFNIPYEVFSELTGLEPVDEFIQALAILSSNSVPEKYCRQRRQLQDAMLDTHFYFGAKRISLALEPDLLWSMVKFLQSMGTQIHAAVTTTRSPLLEQLPIKSVTIGDLEDFEQLAVESDLLIGNSNLAAIAKRLSIPHYRLGIPIYDRLGNGHYTKVGYRGSMEVLFGIGNLFIDAEEARVKNFDENFVTGHG
What is the function of this protein?
This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).
What are the official names of this protein?
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifN.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: RL18_ECOHS
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: EV45_HHV2H
Sequence: MAFRASGPAYQPLAPAASPARARVPAVAWIGVGAIVGAFALVAALVLVPPRSSWGLSPCDSGWQEFNAGCVAWDPTPVEHEQAVGGCSAPATLIPRAAAKHLAALTRVQAERSSGYWWVNGDGIRTCLRLVDSVSGIDEFFEELAIRICYYPRSPGGFVRFVTSIRNALGLP
What is the function of this protein?
Important virulence factor of HSV neurotropism.  Seems to be required for glycoprotein B-induced fusion (By similarity).  Dispensable for growth in vitro.
What are the official names of this protein?
Envelope protein UL45, 18 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 UL45 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Note=In transfected cells, it is retained within the ER.
Protein: NSP5_ROTGI
Sequence: MAEASEFNFNLRRKSRAVTASRRVKEEVKEKQKMDDSKSQVVDVDSVSVYSHESSRSNYSDAYEKLKREPVVEESNDARYRTFEFSEDEETFKPANKMSDKSQRNSKSKHTEGLECSDTVLEKISELTLEIEKVKQMNQPITVDAAFNMTLRNVDNLTTRQKQALVNSIINSMN
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: 3MG1_ECOLI
Sequence: MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVLKKRENYRACFHQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNARAYLQMEQNGEPFVDFVWSFVNHQPQVTQATTLSEIPTSTSASDALSKALKKRGFKFVGTTICYSFMQACGLVNDHVVGCCCYPGNKP
What is the function of this protein?
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
What are the official names of this protein?
DNA-3-methyladenine glycosylase 1, 3-methyladenine-DNA glycosylase I, constitutive, TAG I, DNA-3-methyladenine glycosidase I, DNA-3-methyladenine glycosylase I.
Protein: ENGB_VIBCH
Sequence: MSVKIHYQNTHFITSAPDIRHLPEDEGIEIAFAGRSNAGKSSSLNRLTNQKNLAKTSKTPGRTQLINLFKVADGCHIVDLPGYGFAQVPLEMKLKWQRALGEYLQKRQSLKGLVVLMDIRHPMKDLDQQLIIWAVECGIPVQVMLTKADKLKSGARKAQVLKVREEAKTFGGDVAVDAFSSLSGIGVDTLRAKLDEWYAPMLAALAEQEEGEQPESSTDQ
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MSCL_DESHD
Sequence: MWKEFKEFAMKGNVIDLAVGVIIGGAFGKIVTSLVNDVIMPLVGLLLGQMDFSNAFITLGKGDFATIAEAQAAKVPTLNYGLFINNVVDFLIIAFTIFIVIKQINRFNRKKEVKEEVAEEKATKPCPYCYVEIHKEATRCPHCTSVLESP
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOC_WEIHE
Sequence: RIRYKGIVCDRCGVEVTSAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDMSPRSLEEVIYFASYVVTKPGDTSLTEKQLLSEREYRQLKAEYGNAFEAGMGAEAVQTLLSNVDLEEEVTELKAQLREATGQKRVRAVRRLDIIEAFVKSGNKPEWMVMDVIPIIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLELNAPGIIVQNEKRMLQEAADALVDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQDLLGKRVDYSGRSVIDVGPFLKMNQMGLPRPMAMELFRPFIMKELVKRDLAGNIRAAKRKIDRHDEDVMDVLEDVIKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLVTEAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAGHILAPKDGKPIVAPSQDMVIGNYYLTTEEAGREGEGMIFKDVNEVRTAYQNKYVHLHTRIGIQTASLSAEKPFTAEQRSRIMMTSVGKLFFNDILPADFPYLNEPTEANLHEIDNRFFLEPGEDIKARYAETPILPPFKKGYLSDIIAEVYKIYKVTETSLLLDRMKDLGYDESTKSGLTVGVADVTDLKEKPEIIEDAHKQVATVTKQFRRGLITDSERYERVIAIWNKAKDDITEKLIEHFEPDNNIFMMSDSGARGNISNFTQLAGMRGLMAAPNGRIMELPIIANFREGLSVLEMFFSTHGARKGMTDTALKTADSGYMTRRLVDVAQDVIIREDDCGSDRGLDVSAIMNGNEVIESLYERILGRYAQKSVFEPQTGDKLVGHNEMITEDIAKRIIEAGVTTVTIRSAFTCNTEHGVCVRCYGRNMATGDVVEVGEAVGTVAAQSIGEPGTQLTMRTFHTGGVAGNDITQGLPRVQEIFEARNPKGRAMITEVTGEVTTIEENPADRTKEVTIQGETDTRTYTLPMSSRMRVGEGDHIHRGETLNEGSADPKEIIQVRDTLATENYIVLEVQKVYRMQGVEISDKHIEVMARQMLRKVRVMDPGETDLLPGTLMDIAQFRDANEGTLLKGG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL16_BARQU
Sequence: MLQPKRTRFRKQFKGRIHGVSKGGTDLNFGAYGLKAVEPERITARQIEAARRAITRYMKRSGRVWIRIFPDLPVTSKPTEVRMGKGKGGVEYWAARVAPGRIIFEIDGVLEDVAREALRLGAAKLPIKTRFIQRLAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: LYSET_XENTR
Sequence: MWRVEFVACLRPSCQFCTAMCSILSAGRAWRMMNFRQRMGWIGVSLYLFVSAAAFYYVFEINETYNRLALEHVQLKPQEPHRGTTWTHSLKARLLSLPFWLWAALFLIPYFQVFLFLYSCTRADPKTVGYCIIPICLAIICNRHQSFVKASNQISRLQLIDT
What is the function of this protein?
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes.  LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB.  GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes.  LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.
What are the official names of this protein?
Lysosomal enzyme trafficking factor, Transmembrane protein 251.
What is the protein family that this protein belongs to?
Belongs to the LYSET family.
Protein: CMOA_SALTI
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNTQVYDLGCSLGAATLSVRRNIRHEHCRIIAVDNSPAMIERCRRHIDAYKAPTPVEVVEGDIRDITIENASMVVLNFTLQFLEPAERQALLDKIYLGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLRQAGFEHSELWFQCFNFGSLVALKAGVAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: CSPL3_PHYPA
Sequence: MAEPVIVVPRKGVYSDDSYHHHHRHHSFHSCTNFLLRTLTAGATAAAVVVMLISTQTSGTIYGYFRGRWRDYPAYKWLIIANAVVFVYSVMAAIVACFSVIARRGPLSYSPSAWLTLLVDFLAASALISAASAALAVALLARNGQDLQGTHYWPTVCNYVSKFCDYTQGAIIASFVGFGLLFLSTLLAASALYHLSHRRH
What are the official names of this protein?
CASP-like protein 1U2, PpCASPL1U2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 6PGD_CAEEL
Sequence: MAEADIAVIGLAVMGQNLILNMNDHGFTVCAFNRTVKLVDDFLANEAKGTKIIGAHSIEEMCKKLKRPRRVMMLIKAGTPVDMMIDAIVPHLEEGDIIIDGGNSEYTDSNRRSEQLAAKGIMFVGCGVSGGEEGARFGPSLMPGGNPKAWPHLKDIFQKIAAKSNGEPCCDWVGNAGSGHFVKMVHNGIEYGDMQLIAEAYHLLSKAVELNHDQMAEVLDDWNKGELESFLIEITANILKYRDEQGEPIVPKIRDSAGQKGTGKWTCFAALEYGLPVTLIGEAVFARCLSALKDERVRASKQLPRPQVSPDTVVQDKRVFIKQISKALYASKIVSYAQGFMLLAEASKQFNWNLNFGAIALMWRGGCIIRSRFLGDIEHAFQKNKQLSNLLLDDFFTKAITEAQDSWRVVVCAAVRLGIPVPAFSSALAFYDGYTSEVVPANLLQAQRDYFGAHTYELLAKPGTWVHTNWTGTGGRVTSNAYNA
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: PHS_DINSH
Sequence: MAQKLDDSTRDEHLAPLMRAGWEMVEGRDAIKKTFVFGDFTEAFAFMTGTALWAEKWDHHPEWSNVYKTVEVTLTTHDVGGLSELDIKLASKMDNLA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: NLT2G_WHEAT
Sequence: MAGMMKKQVVTALMLALVVLAAAPGGARAACQASQLAVCASAILSGAKPSGECCGNLRAQQGCFCQYAKDPTYGQYIRSPHARDTLTSCGLAVPHC
What is the function of this protein?
Transfer lipids across membranes.  May play a role in plant defense or in the biosynthesis of cuticle layers.
What are the official names of this protein?
Non-specific lipid-transfer protein 2G, LTP2G, 7 kDa lipid transfer protein 1, Lipid transfer protein 2 isoform 1, LTP2-1.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family. B11E subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ZNRF4_HUMAN
Sequence: MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVSSAPPEAPGQ
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966).  Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830).  Could have a role in spermatogenesis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase ZNRF4, Nixin, RING finger protein 204, RING-type E3 ubiquitin transferase ZNRF4, Zinc/RING finger protein 4.
Protein: UFD1_DICDI
Sequence: MNLDEYVRSLRGEVMGHHHGGPGRYEQKFKAFPISFLPKEKHSLESGGKILLPPSALNALSRLNIQYPMLFEISNPISGKKSHCGVLEFIAEEGICYLPLWMMQNLQLKEGEFIDIKNATLAKGTFVKIQPRTSNFIDISNPKAVLENSLRKFATLTKDDEIMIDYNNTKYYLKVVELKPANAISIIEADVSVDFAPPMDSKEATSPSTSSPGSHVSGPSKGLTFGPASTSAKPIPGGKKKKDESDSDSDSDDEPKFKAFAGTGARLDGKVGTPLGTSPKTLNTNNNNNNNNNNNNNNNNNNNNNSNNNNTKNEDTKFKSFSGKGHSLKD
What is the function of this protein?
Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway.
What are the official names of this protein?
Ubiquitin fusion degradation protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UFD1 family.
Protein: TUSA_SHIBS
Sequence: MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ANADF
Sequence: MGVRSDTIKKGFERAPHRSLLRATGLTDADFDKPFIGIANSHVDIIPGHFFLQEYGRIAKDEIRKAGGVPFEFNTIGVDDGIAMGHAGMLYSLPSRELIADSIETMMNAHSLDALLCIPNCDKIVPGMLMGALRVDVPTVFCSGGPMKAGRMADGTAIDLTTAFEAVGKRALGQMSDAELYEIECKACPSGGSCSGMFTANSMNVLCEAMGVALPGNGTALALTPEREALLRRAARRAVEIAGDERFRLRRIVNADAIHNAMVVDMAMGGSSNTVLHMLAIAREAGVEFGLRQIEAVAAKVGHIAKIAPSLSTVHIEDVHRAGGVPAVLHEVARRGGVVREDALTVTGETVGERIRGAEIKDRSVIHPLEEAYSAVGGLAVLFGNLAPEGAVVKTAGIQPSMRKFTGRAICFDSQEEAIAGIMGGKVKPGHFVVIRYEGPRGGPGMQEMLAPTSLIMGMGLGEQVALATDGRFSGATRGACVGHVSPEAAEGGPLALVQDGDAVTIDVEARALTVDVPDAELARRREGFRPKRKEIRSSWLKRYALLVSNASAGAVMKTEL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CYB_PANTS
Sequence: MTNIRKSHPLIKIINHSFIDLPAPSNISAWWNFGSLLGVCLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLYMHVGRGMYYGSYTFSETWNIGIVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFTLPFIVSALAAVHLLFLHETGSNNPSGMVSDSDKIPFHPYYTIKDILGLLVLVLTLMLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPALHTSKQRGMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIAIGQLASILYFFILLVLMPISGIIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MAGL2_HUMAN
Sequence: MSQLSKNLGDSSPPAEAPKPPVYSRPTVLMRAPPASSRAPPVPWDPPPIDLQASLAAWQAPQPAWEAPQGQLPAPVVPMTQPPALGGPIVPAPPLGGPMGKPPTPGVLMVHPPPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPPPGTPMSHPPPPGTPMAHPPPPGTPMAHPPPPGTPMVHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAQPPAPGVLMAQPLTPGVLMVQPAAPGAPMVQPPPAAMMTQPQPSGAPMAKPPGPGVLMIHPPGARAPMTQPPASGAPMAQPAAPPAQPMAPPAQPMASWAPQAQPLILQIQSQVIRAPPQVPQGPQAPPAQLATPPGWQATSPGWQATQQGWQATPLTWQTTQVTWQAPAVTWQVPPPMRQGPPPIRPGPPPIRPGPPPVRQAPPLIRQAPPVIRQAPPVIRQAPPVIRQAPAVIRQAPPVIRQAPPVIRQAPPVIRQAPPLIRQAPPPIRPAPQVLATQPPLWQALPPPPPLRQAPQARLPAPQVQAAPQVPTAPPATQVPAAPPAGPQVPQPVLPAPLSAPLSAPQAVHCPSIIWQAPKGQPPVPHEIPTSMEFQEVQQTQALAWQAQKAPTHIWQPLPAQEAQRQAPPLVQLEQPFQGAPPSQKAVQIQLPPQQAQASGPQAEVPTLPLQPSWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTPSGECRASSIDRRGSSKERRTSSKERRAPSKDRMIFAATFCAPKAVSAARAHLPAAWKNLPATPETFAPSSSVFPATSQFQPASLNAFKGPSAASETPKSLPYALQDPFACVEALPAVPWVPQPNMNASKASQAVPTFLMATAAAPQATATTQEASKTSVEPPRRSGKATRKKKHLEAQEDSRGHTLAFHDWQGPRPWENLNLSDWEVQSPIQVSGDWEHPNTPRGLSGWEGPSTSRILSGWEGPSASWALSAWEGPSTSRALGLSESPGSSLPVVVSEVASVSPGSSATQDNSKVEAQPLSPLDERANALVQFLLVKDQAKVPVQRSEMVKVILREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYIIINKLGYHTGNLVASYLDRPKFGLLMVVLSLIFMKGNCVREDLIFNFLFKLGLDVRETNGLFGNTKKLITEVFVRQKYLEYRRIPYTEPAEYEFLWGPRAFLETSKMLVLRFLAKLHKKDPQSWPFHYLEALAECEWEDTDEDEPDTGDSAHGPTSRPPPR
What is the function of this protein?
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.  Acts as a regulator of retrograde transport via its interaction with VPS35.  Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853).  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity).
What are the official names of this protein?
MAGE-like protein 2, Necdin-like protein 1, Protein nM15.
What are the subcellular locations of this protein?
Early endosome. Cytoplasm. Nucleus. Note=Recruited to retromer-containing endosomes via interaction with VPS35. Colocalizes with CLOCK and ARNTL/BMLA1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus (By similarity).
Protein: SPPA_SALTI
Sequence: MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGALGRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQYYLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYLHTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKTPADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVVVSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLSIEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMVMDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR
What is the function of this protein?
Digests cleaved signal peptides in vitro, its in vivo function is unknown.  This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity).
What are the official names of this protein?
Protease 4, Endopeptidase IV, Protease IV, Signal peptide peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S49 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YJZ0_YEAST
Sequence: MKFLPFLRFCTWYVILVRGSPPLMKYECSDVGKKFNGTVCNDASSDCDTSVPPKVPLDPTGAAGRYFVTKLVGERGTSSNIFSRLDMAILEALIFMQSCLILSCSWWILN
What are the official names of this protein?
Putative uncharacterized protein YJR020W.
Protein: ANMK_ACAM1
Sequence: MHVIGLMSGTSVDGIDAALVEISGRELDLQVDLIAAQTYPYPDALRNQILAVCRGEPLSIEALAGLDDAIAMQFAQAAQSIQAEATLTAELIGSHGQTVFHRPPQGNLGYTLQIGRGAVIAHQTGINTVSNFRVADMAAGGQGAPLVSKLDICLLSHPEFYRCVQNIGGIGNVTYLPPLTDASQLGMGVKGWDTGPGNVLMDLAVAHFSKGELTYDADGAWAAQGNPCQPLIEEWLRHPFFQAPPPKSTGRELFSPDYLQTCLQTAASYQLSPADMLATLTDFTAATIVYNYDQFLPHPPDQVVLCGGGSRNGYLRQCLQQRLGGSTVLTTDDVGLNSDAKEAIAFAVLAYWQQLQIPGNVPAVTGASGPILLGELHLV
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: IHH_DEVDE
Sequence: VMNLWPGVRLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Indian hedgehog protein, IHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Indian hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Indian hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: TRPC_RHOPB
Sequence: MSDILTKIEAYKREEIAAAKRARPLAELAAAAKTASPPRGFVAAIREKLAGGDTALIAEIKKASPSKGLIRADFDPPALAKAYQQGGAACLSVLTDTPSFQGSLDYLVAARAAVTLPVLRKDFMFDTYQVVEARAHGADCILIIMAALDDAAAQDIEDAAIALGMDVLIEIHNRDELERALKLRSPMIGVNNRNLRSFEVTLATSEALAPLIPADRLMVGESGIFAPADIARLERVGIATFLVGESLMRQHDVAAATRTLLARDSLRTTGTR
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: GLGA_STRPI
Sequence: MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYYDMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDFDDGERFAFFQLAAIEAMERIAFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVLTIHNLEFQGQFSEGMLGDLFGVGFERYADGTLRWNNCLNWMKAGILYANRVSTVSPSYAHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAKNKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPAFEGAFSWFAQIYPDKLSANITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGTLPLVHEVGGLRDTVCAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNLQKQAMESDFSWDTACKSYLDLYHSLVN
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: TAM_RHOP5
Sequence: MADWSAEQYLKFEDERTRPARDLLAQVWLDDPRRVVDIGCGPGNSTELLVKRWPQAKVTGVDNSADMLRQARERLPGHNFIEANIAHWVAPVGTEVVFANAVFQWVPNHLKHMQRLLGALAPGGVLAVQMPDNLDELSHILMREVAFQEPWREQLSTAAELRDTLPKPGVYYDALRPLCSRLEIWHTVYNHALDSAAAIVEWVRGTGLRPFVDPLELPERKAYLAAYTARIAAAYPPQADGKVLLRFPRIFIVASK
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.