PharMolix/UniProtQA huggingface dataset:
Protein: RSMA_SHEAM
Sequence: MSNKVHLGHTARKRFGQNFLTDGNIINRIVGAISPDDDHVMVEIGPGLAALTEPVAMGIKNLTVIELDRDLAERLKVHPTLKDKLTIHQGDAMKFDFSQLVEPERKLKVFGNLPYNISTPLMFHLFEFAEHIENMHFMLQKEVVLRLSASPGTKAYGKLTVMAQYYCQVVPVLEVPPGCFTPPPKVDSAVVRLVPYAEKPWPCHDVEMLRKVCNTAFNMRRKTLRNNLKPLLQDADFDVLGIDAGLRPEDISVAQYVAMANYLCEKR
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYN3_KLULA
Sequence: MATKLEAFINDLRLQCETNDTTKYVSIVLFCEKETTLKLFFQYIDGIDTNSEPKLAVLSPTLSPVGYYTKEITTEDGWQVILNITCIPPPWKSSSIDLLPSILKSDPEKSSKRFVLLLDWINEDQSYWLEDIEGLFVQLKQVSPETKAAGSVMMLHSDYCKHLENTHTKWSSTAIDFMHQSLRTLALHLKISLYSDLKNSVLAAKSAVGVPLSTEEQKSLIDMVNLENVNVTYGSDSLNKIAMIDENFPLSVYKDNLSTLKHDFSDVIPEIKPRNMGSCAITEPIKPLPDLQSLIPDVQGQLSHLYELQRKNSSLKRVTNQPAVVQDIGQDNTMALNDIASDNNHLQHVPDDDSALDSLVHGIVQRHQIS
What is the function of this protein?
Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast.  Probably required for normal progression of the cell cycle (By similarity).
What are the official names of this protein?
Cytoplasmic dynein intermediate light chain DYN3, Dynein protein 3.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain DYN3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GLGSY_MYCTU
Sequence: MRILMVSWEYPPVVIGGLGRHVHHLSTALAAAGHDVVVLSRCPSGTDPSTHPSSDEVTEGVRVIAAAQDPHEFTFGNDMMAWTLAMGHAMIRAGLRLKKLGTDRSWRPDVVHAHDWLVAHPAIALAQFYDVPMVSTIHATEAGRHSGWVSGALSRQVHAVESWLVRESDSLITCSASMNDEITELFGPGLAEITVIRNGIDAARWPFAARRPRTGPAELLYVGRLEYEKGVHDAIAALPRLRRTHPGTTLTIAGEGTQQDWLIDQARKHRVLRATRFVGHLDHTELLALLHRADAAVLPSHYEPFGLVALEAAAAGTPLVTSNIGGLGEAVINGQTGVSCAPRDVAGLAAAVRSVLDDPAAAQRRARAARQRLTSDFDWQTVATATAQVYLAAKRGERQPQPRLPIVEHALPDR
What is the function of this protein?
Glucosyltransferase that uses UDP-glucose as the sugar donor to elongate alpha-(1->4)-glucans.  Is involved in the biosynthesis of both 6-O-methylglucosyl lipopolysaccharides (MGLP) and glycogen.  May also use ADP-glucose as substrate.
What are the official names of this protein?
Glycogen synthase, Alpha-1,4-glucosyltransferase Rv3032, UDP-glucose--glycogen glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: HTMR_MYCTU
Sequence: MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD
What is the function of this protein?
Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region (PubMed:26303802, PubMed:27432954, PubMed:28743871).  Also represses the expression of at least five other genes, including the methyltransferase Rv0558 (PubMed:26303802).  Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil (PubMed:28743871).
What are the official names of this protein?
HTH-type transcriptional repressor Rv2887.
Protein: MTB3_SOLLC
Sequence: MAEKFFLKGEDKVNMEGVLGSEAVEFFSWSASNHMLTEFTSSRGDLGVQQALCKIVEGSDWTYAIYWQVAKSKSGKSALIWGDGHCRETKIGQGEGANDSAHQKMMDGNKKKMVLQKIHTCFGGSEDDNIAAKLESVSDVEVFYLTSMYYIFPFDKPSSPSQSFNSARSIWGSDLKGCLEHFQSRSYLAKLARFETLVFVPLKSGVVELGSVKSIPEDQNLIQMVKTSVVVSNPPQPKANTKIFGRELSLGGAKSGPISINFSPKVEEELSFASDSYEVQAALGSSQVYGNSSNGYRSDEGEGKLYKEELDERKPRKRGRKPANGREEALNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITDLQARIRVLDAEKEMVGDKQKQQVILEIDFHQRQDDAVVRVGCPLNAHPVSRVLKTFQEHQVVAQESNVSLTENGELVHMFSIRAPGPAAEDLKEKLTAASRFALKTRWSVSVIRLLCFARLFVYEHQCLAGKFALYFVDYTI
What is the function of this protein?
Transcription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166).  Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166).  Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166).
What are the official names of this protein?
Transcription factor MTB3, Basic helix-loop-helix protein 138, Protein MYC2-TARGETED BHLH 3, Transcription factor bHLH138, bHLH transcription factor bHLH138.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABZ_BARHE
Sequence: MITTEGTRSLETLDIEKLLSILPHRYPFLLIDRIVEIDGEQEAIGIKNITINEPHFVGHFPAKPVMPGVLILEAMAQTAGAISLLRLGNKQTNLVYLMTVDNAKFRKPVIPGDQLKIHVRLLKKRSGMRRFSCIAEVKGVRVAEAEIAAMILEKE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OST3_ORYSJ
Sequence: MESPPHPLLLLLTLLVAAGAASAGADDLVAELQSLRSRSPSGVIHLTDTSITRFLSAPAPRPYSVLVFFDAASLHSKTDLHLPQLRREFALLSASFLAHNPASADLFFADIEFSESQHSFAQFGVNSLPHVRLVRPEHTRLAGSEQMDQSHFSRLADSMAEFVESRTGLEVGPIVRPPLVSRNQMILLVILFLVSIPFLIKRIMDGETLFHDRRVWMAGALFIYFFSVSGGMYGIIRHTPMFITDRSDPNKLVFFYQGSGMQLGAEGFAVGFLYTLVGLMIAMVTHLLVRVESLQIQRFTMLAVMIIGWWAVKKVILLDNWKTGYSIHTFWPSSWR
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the OST3/OST6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ADM1B_XENLA
Sequence: MSSGALFPSLVPGSRGSSSKYLVEFRAGKMSLKGSTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGSVDDDLIIFPDDCEFKRVSQCTTGRVYVLKFKAGSKRLFFWMQEPKTDKDEEHCRKVNEYLNNPPMPGALGGSGSGSHELSALGGEGGLQSLLGNMSHNQLMQLIGPTGLGGLGGLGALTGPGLASLLGSGGPTTSSSSSSSRSQSAAVTPSSTTSSTRTTSAPVAPAAAPATTPSPAVSSNDGASAATSPTQAIQLSDLQNILATMNVPATGEGGQQVDLASVLTPEIMAPILANAEVQERLMPYLPSGESLPQTADEIQNTLTSPQFQQALSMFSAALASGQLGPLMSQFGLPADAVDAANKGDIEAFAKAMQSTSSQKERESSEKKEEEEDMSLD
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  Within the complex, functions as a proteasomal ubiquitin receptor.
What are the official names of this protein?
Proteasomal ubiquitin receptor ADRM1-B.
What is the protein family that this protein belongs to?
Belongs to the ADRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZAPA_CITK8
Sequence: MSAQPVDIQIFGRSLRVNCPPEQRDALNQAADDLNQRLQDLKVRTRVTNTEQLVFIAALNISYELTQEKAKTRDYAASMEQRIRMLQQTIEQALLDQGRITEKTGQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: PRP8B_ARATH
Sequence: MWNIDGTSLAPPGTDGSRMQTPSHPADHPSYTAPSNRNTPTVPTPEDAEAKLEKKARTWMQLNSKRYGDKRKFGFVETQKEDMPPEHVRKIIRDHGDMSSKKHRLDKRVYLGALKFVPHAVFKLLENMPMPWEQVRDVKVLYHITGAITFVNEVRWVVEPIYMAQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNLLDVDPLEAIQLELDEEEDSAVYSWFYDHKPLVKTKMINGPSYQTWNLSLPIMSTLHRLAAQLLSDLVDRNYFYLFDMPSFFTAKALNMCIPGGPKFEPLHRDMEKGDEDWNEFNDINKLIIRSPLRTEYKVAFPHLYNNRPRKVKLCVYHTPMVMYIKTEDPDLPAFYYDPLIHPISNSNNTNKEQRKSNGYDDDGDDFVLPEGLEPLLNNSPLYTDTTAPGISLLFAPRPFNMRSGRTRRAEDIPLVAEWFKEHCPPAYPVKVRVSYQKLLKCYLLNELHHRPPKAQKKKHLFRSLAATKFFQSTELDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDANVQFRLGNVDAFQLADGLQYIFSHVGQLTGMYRYKYRLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPMWRVWLFFLRGIVPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDVVDAMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPVAIENMILRYVKSKADWWTNVAHYNRERIRRGATVDKTVCRKNLGRLTRLWLKAEQERQHNFQKDGPYVTADEGIAIYSTTVNWLESRKFSAIPFPPLSYKHDTKLLILALERLKESYSAAVKLNQQQREELGLIEQAYDNPHEALMRIKRHLLTQHSFKEVGIEFMDLYSHLIPVYQIDPLEKITDAYLDQYLWYEGDKRHLFPNWIKPADSEPPPLLVYKWCQGINNLQGIWDTSDGQCVVMLQTKFEKLFEKIDLTVLNSLLRLVLDPKLANYVTGKNNVVLSYKDMSYTNTYGLIRGLQFASFVVQFYGLVLDLLLLGLTRASEIAGPPQRPNEFMTYWDTKVETRHPIRLYSRYIDKVHIMFKFTHEEARDLIQRHLTERPDPNNENMVGYNNKKCWPRDARMRLMKHDVNLGRSVFWDMKNRLPRSITTLEWENGFVSVYSKDNPNLLFSMCGFEVRVLPKIRMGQEAFSSTRDGVWNLQNEQTKERTAVAFLRADDEHMKVFENRVRQILMSSGSTTFTKIVNKWNTALIGLMTYFREATVHTQELLDLLVKCENKIQTRVKIGLNSKMPSRFPPVIFYTPKEIGGLGMLSMGHILIPQSDLRYSNQTDVGVSHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAQAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQALKQNPFWWTHQRHDGKLWNLNNYRTDVIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIYMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVLDQELEPLEIETVQKETIHPRKSYKMNSSCADVLLFAAHKWPMSKPSLIAESKDVFDQKASNKYWIDVQLRWGDYDSHDIERYTKAKFMDYTTDNMSIYPSPTGVIIGLDLAYNLHSAFGNWFPGSKPLLAQAMNKIMKSNPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGEIFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGVIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKIEKFGDLILKATEPQMALFNIYDDWLMTVSSYTAFQRLILILRALHVNNEKAKMLLKPDMSVVTEPNHIWPSLTDDQWMKVEVALRDLILSDYAKKNKVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLTAVTTRTTNVHGDELISTTISPYEQSAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIMPKNILKKFICIADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQCGNHQQVQLPSSLPEHQFLDDLEPLGWIHTQPNELPQLSPQDVTFHTRVLENNKQWDAEKCIILTCSFTPGSCSLTSYKLTQAGYEWGRLNKDTGSNPHGYLPTHYEKVQMLLSDRFFGFYMVPENGPWNYNFMGANHTVSINYSLTLGTPKEYYHQVHRPTHFLQFSKMEEDGDLDRDDSFA
What is the function of this protein?
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs.  Required for the assembly of the U4/U6-U5 tri-snRNP complex.
What are the official names of this protein?
Pre-mRNA-processing-splicing factor 8B, PRP8 homolog B, AtPRP8B.
What are the subcellular locations of this protein?
Nucleus.
Protein: SR1IP_RAT
Sequence: MAVPGCNKDNVRAGCRKCGYPGHLTFECRNFLRVDPKRDIVLDVSSTSSEDSDEESEELNKLQALQEKRINEEEEKKKEKSREKIKLKKKRKRSNSSTTEEDSSKQKKQKYQKKEKKKEKKNKSKKGKHHKKEKKKRKKEKRSSPNRSEVTKK
What is the function of this protein?
Possible splicing regulator involved in the control of cellular survival.
What are the official names of this protein?
Protein SREK1IP1, SFRS12-interacting protein 1, SREK1-interacting protein 1.
Protein: Y354_METJA
Sequence: MQINKAIELLERAWSDYNNGDTVGAILKLEEAEDLIRKLRVRLCSEIRREGYDAIFIK
What are the official names of this protein?
Uncharacterized protein MJ0354.
Protein: ISCA_SALPA
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTAEDTVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFSNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: XGPT_EDWI9
Sequence: MSEKYVVTWDVLQMHTRKLAARLLPAERWTGIIAVSRGGLVPAAILARELGIRHVDTVCISSYDHDNQRELRVLKCAEGDGEGFIVVDDLVDTGGTAQAIRDMYPKAHFVTIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMGVSFVEPLSGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FRDD_ECOLC
Sequence: MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIS1_YEAS1
Sequence: MTNWQQQLPLTDTQKNELDKSVLRYLNWNYKQTVRHEHAQDYESVRHAIVTLSGFLLQESVDRQEFISNNDTSNESMVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNGASAHNVLKWIPRNLPSCLINVESSVTSVKLHPNLPIVFVATDHGKLYAFDLFNYTIPLASLQSHTKAITSMDVLFTNFTNSSKKNYLVVVTASKDLQIHVFKWVSEECKFQQIRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWVRSIDVLGDYIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTPSTDRYKNWGMQYCVSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWVRDISIRGQYLFSCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMMVTGGLDCKSNVFMR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  Plays a central role in positioning the mitotic spindle at the bud neck during cell division.  Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles.
Protein: UHD1_USTMA
Sequence: MAGTSRNVRVLVTGANGFVGSHIVSLLLSRGYVVNATVRRQTASEKLIATFACDRLHVFVIPDLTSEQALDEAIRGCKYVVHVASTVPSKEQASGIDIDSAISSIESVMNSAVAHASEKVVLTSSMSTHLDVKAPILNESTWYTPDRSSTKLMVQYMSSKTLVERRAWELSSTLKLPLTTVAPVYIGGPTIIHEQDPKSSVSNQDLLRCIEDESRSRIPGWIDVRTVAHLHLHAIEDHSLNGRRILACTHNRGVVPMDCSLMNSLLAKDSAALIDFDRTKRDLLEQIDAFNSGQTRRVVA
What is the function of this protein?
Fatty acid hydroxylase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA) (PubMed:15932999, PubMed:17850255).  UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U. maydis (PubMed:15932999, PubMed:17850255).  UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group (PubMed:17850255).  In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid (PubMed:17850255).  UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1 (PubMed:17850255).  Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2 (PubMed:17850255).  Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable).  The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable).  The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable).  The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable).  The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion (PubMed:17850255).
What are the official names of this protein?
Fatty acid hydroxylase uhd1, Ustilagic acid biosynthesis cluster protein uhd1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: DD21B_XENLA
Sequence: MPGKVYTDEMEGKSIKKKKLTETPLPKLKKRKMQNGETEDLDLEHVTESVNGEINNNNPTPKLKKNKKPAPKSDLSETAEQCDGEQPDPSTPTPKKVKKKKLKEGKEDSDAQEETNISLSSQGGQCDGEQPDPSTPTPKKIKKKKLKEGKEDSDAQEETDISEPQMNGVKSVKKSKKNTTGDEPAPKKRKTDTSEITAANECEEKELTKEEEEIKKEKIDGDFSKFPISKDTIKNLQAKGVTYLFPIQSKTFHTVYSGKDVVVQARTGTGKTFSFGIPLVERLSEDQQPLARGRAPRVIILTPTRELAIQITNELRSMTKKLKVACFYGGTPYQQQVFAIKDGIDFLVGTPGRIRDLVQNYRLDLTALKHVVLDEVDMMFDVGFSEQVEEILSVRYKPDPEENPQTLLFSATCPDWMYNVAKKYMRKQYEKVDLVGHRSQKAAITVEHLAIECNRSQKAAVLGDIVQVYSGSHGKTIIFCDSKLQAHELSTNCGSLKQSAKPLHGDLQQKEREVVLKGFRQGTFEVLIATNVAARGLDIPEVDLVVLYSAPKEADAYVHRSGRTGRAGRTGVCISLYEPWEKHYLRNVERSTGITFKRVGIPSLMNVAKSSSADAIKSLDTVPADVIEHFKEYAQELIEKKGALTALAAALAHISGATSIKQRSLLNMEAGYMTITLKSSVPIHNLSYAWRSIKEQLGEDVDSKIHRMCLLKDSMGVCFDVRSEDLQSMQESWSDTRRWQFTITTELPEIQESERSFDGPRNRSFGGRGRRPFDRRNNSRNSSGGGGGRRGRSGGFRRGR
What is the function of this protein?
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity).  Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity).  In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (PubMed:12851405) (Probable).  Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity).  In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity).  Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability (By similarity).
What are the official names of this protein?
Nucleolar RNA helicase 2-B, DEAD box protein 21-B, Gu-alpha-B, Nucleolar RNA helicase Gu-B, xGu-2, Nucleolar RNA helicase II-B, RH II/Gu-B.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Mitochondrion.
Protein: TRIM5_PANPA
Sequence: MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTKSETEMVQQTQSVRELISDLERRLQGSVMELLQGVDGVIKRMENVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELTDVRRYWVDVTVAPNNISCAVISEDMRQVSSPKPQIIYGARGTRYQTFMNFNYCTGILGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDAMCNIEKNENYQPKYGYWVIGLEEGVKCSAFQDGSFHTPSAPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPYLNPRKCGVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: YCIB_POLAQ
Sequence: MKFLFDLFPIILFFIAYKFGGIYQATIVAMVATIVQILWVYYRHRKIDAMQWVSLIMIMVFGSLTIFLHDSTFILLKPTALYWLFSGVLFVSAQFFNKNWIQVLMGKQITLKPTHAHTVWHQLNLAWSAFFFFMGFLNLYIAFEYSEETWVNFKLFGSTGLLIAFVIAQGFWMSRHIEHPAE
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.