PharMolix/UniProtQA huggingface dataset:
Protein: TEN3_TENMO
Sequence: MKTFVICLILVVAVSAAPDHHDGHLGGHQTGHQGGQQGGHLGGQQGGHLGGHQGGQPGGHLGGHQGGIGGTGGQQHGQHGPGTGAGHQGGYKTHGH
What is the function of this protein?
Antifungal heat stable protein produced in response to injury.  It is active against C. albicans.  No antibacterial activity against Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Tenecin-3.
What is the protein family that this protein belongs to?
To H.diomphalia holotricin 3.
What are the subcellular locations of this protein?
Secreted.
Protein: YBEY_POLSJ
Sequence: MAPDVPLRQLDLSLQFGQFPGVARHRAALPRRRVQRWISHALKTDAEITVRIVDAEEGQSLNRDYRRKDYATNVLTFDYTREPVVTADLVLCAPVVEREAREQGKTLEAHYAHLLVHATLHAQGYDHETNERDALEMEALEILLLASLRFANPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BURM7
Sequence: MATTRKPRGGAGGATQPALDFDAPGEIVCGVDEAGRGPLAGPVVAAAVVLDPARPIVGLDDSKALSAKKRERLFDEIVAYALAYSVASASVEEIDSLNILHATMLAMKRAVEGLSVLPTLAKIDGNRCPMLAIRSEAIVGGDALVPSISAASILAKVTRDRMLVELHQQFPMYGFDAHAGYGTPQHLAALREHGPCEHHRRSFAPVREAFDLIR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_MACCJ
Sequence: MEKLQQRVKEDGVVIDGGILKVDSFLNHQIDPELMYEVGETIYNKYKDEGITKVLTIEASGIAPAIMTALKFKVPCLFAKKSVPSTLTEEVYHTDIHSYTKNKTSHVVVSKRFLSENDRVVIIDDFLANGEAALGLYNLVQQAGATCVGVGIVVEKSFQSGKQRLLDAGLDVTSLCEIAALDNGKVTLVGEGEL
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_CHLSY
Sequence: MKVLHTVAEFRQARAAFDVLGFVPTMGYLHQGHLALVEQARRECPAVAVSIFVNPTQFGPNEDYARYPRDTNRDLALLEAAGVDLVFIPSVEEMYPPGFGTYVIQPAADEVLEGAARPGHFRGVATVVCKLFNIVQPTKSYFGQKDAQQTVVVRQMVRDLNLPVEIVIVPTVREPDGLALSSRNVYLNAEQRAAAPVLYRALRTAAERYAAGERDAETLRAVMRSVLAGEPLARPDYVSVAHPLTLRELDRIGADGALLSMAVRFDQVRLIDNWLLEGEGK
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_KLEAE
Sequence: MERYETLFAQLKNRQEGAFVPFVTLGDPGPEQSLKIIDALIEGGADALELGIPFSDPLADGPTIQGAALRAFAAGVTPAQCFEMLAAIRQKHPTIPIGLLMYANLVFSPGIDAFYAQCARVGVDSVLVADVPVEESAPFRQAAMRHNIAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLHHLVEKLAEYHAAPPLQGFGISAPEQVSAAIDAGAAGAISGSAIVKIIERHLDEPQTMLDELKAFVQSLKAATKTA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: SUCC_KLEP3
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVKSKEEIRAFAEHWLGKRLVTYQTDANGQPVNQILVEAATDIDKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKIAIDPLAGPMPYQGRELAFKLGLEGKQVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDNVKAVLVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKSLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: DAPA_SULNB
Sequence: MNNYISGATTAIITPFKNGTLDEATYANLIQRQIDNNIDAICPVGTTGESATLSHDEHKRCIEIAVEVCKGSNAKVLAGAGSNATHEAIDIAKHAEACGVDALFSVSPYYNKPSQEGLYQHYKAIASAVEVPFMLYNVPGRTGVDILPDTVKRLFDDVWNIMGIKEATGSIERTVELLAKVPDLYVFSGDDSIDFPILASGGKGITSVTANLLPDMKADLTHAALRGDFKTSKAINDELFEINKVLFCESNPIPIKAAMYIAGLIDTLEYRLPLVPPSSENMKKIENVMKKYKIVGA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPP3_ORYSJ
Sequence: MTNHAGFAADDAVTAAVPVQAAQGGRHFPPFLAPSSRLTDCKKAAAHVDLAGAGGVATVPGSWPRHAKPVSGAELDDWMEKHPSALAWFESVAAAAKGKEIVVFLDYDGTLSPIVADPDRAFMSDEMREAVRGVAKHFPTAIVSGRCIDKVFDFVKLEELYYAGSHGMDIRGPTAAASEYNHNMKAKQGDAVTFQPAADFLPVIEEVYHVLKERMASIRGSLVENNKFCLSVHYRCVDEAEWGVLDGKVRAVIEGYPDLRLSKGRKVLEIRPVIDWDKGSALQFLLKSLGYEGRNNVFPIYIGDDRTDEDAFKVLRNMGQGIGILVTKVPKETAASYTLREPSEVKEFLRKLVKIKINGDKGLIGK
What is the function of this protein?
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.  Trehalose accumulation in plant may improve abiotic stress tolerance (By similarity).
What are the official names of this protein?
Probable trehalose-phosphate phosphatase 3, OsTPP3, Trehalose 6-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the trehalose phosphatase family.
Protein: YOAH_SALPB
Sequence: MFAGLPSLSHEQQQKAVERIQELMSQGMSSGEAIAQVAGELRANHTGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: 3SO1_NAJAT
Sequence: MKTLLLSLVVVTIVCLDLGYTRLCLSDYSIFSETIEICPDGHNFCFKKFPKGITRLPWVIRGCAATCPKAEARVYVDCCARDKCNR
What are the official names of this protein?
Neurotoxin-like protein NTL2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group I sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYH_CAMHC
Sequence: MIQALRGMNDMMDDEAKLYKKIIDVCEDTAKKYGYEYIEIPKLEETALFKRSVGESSDIVGKEMYQFTDKSGNDVCLRPEGTAGVVRAFIEHKMDRAGGVKKYFYHGSMFRYERPQKGRLREFHQFGIECFSEGSVYEDASVILMLSEILKKLDIEATLKINSLGDGDCMPKYREKLLKFLKENENELCSDCKRRISTNPIRVLDCKVEHCQKILQNAPLITENLNEICAGEFSKLQEILTANGVTFEVDPKLVRGLDYYTKTAFEFVSGEIGSQSAVGGGGRYDNLVAFLGGRPTFGVGFALGIERFMEILSSKESKQKRVGIYICALDKKYIDKIFKIGIDLRRNFKVEISYEAKNLQKHLKNADNKNAEIFLCMGENEAKNDELFMKNLIAKTNKNIKIAEILKEIR
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_PSELT
Sequence: MERDFCEIKLDEPLKYHTSFKIGGPARLFVVPNSIEGLICALSHFPDAKILGRGTNILAPDSGVDVVISTVNLNKCFVDDELIVCESGASLFSVCKKASHNSLSGLEFAYGIPGSVGGAIYMNAGAYGGQICDVVAWVEVYDGEKVMTLDRSQLEFSYRKSIFQRTRWMILKAAFKLKKADMNEINNAMEEIMTRRMESQPMDMPSAGSVFKKPGEDFYVARVIEEIGLKGLRVGDAQISTKHAGFIVNLGEARSSDVLKLIEIIRHRVKEHCGIQLQLEVEIW
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_STRR6
Sequence: MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIVLEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDLEAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFAGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQLGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDEEKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAFRGVGSIEDVIAKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYV_BACTN
Sequence: MELASKYNPADVEGKWYQYWLEHRLFSSKPDGREPYTIVIPPPNVTGVLHMGHMLNNTIQDILVRRARMEGKNACWVPGTDHASIATEAKVVNKLAAQGIKKTDLTRDEFLKHAWDWTEEHGGIILKQLRKLGASCDWDRTAFTMDEERSKSVLKVFVDLYNKGLIYRGVRMVNWDPKALTALSDEEVIYKEEHGKLFYLRYKVEGDPEGRYAVVATTRPETIMGDTAMCINPNDPKNAWLKGKKVIVPLVNRVIPVIEDDYVDIEFGTGCLKVTPAHDVNDYMLGEKYNLPSIDIFNDNGTLSEAAGLYIGMDRFDVRKQIEKDLDAAGLLEKTEAYTNKVGYSERTNVVIEPKLSMQWFLKMQHFADMALPPVMNDELKFYPAKYKNTYRHWMENIKDWCISRQLWWGHRIPAYFLPEGGYVVAATPEEALAKAKEKTGNAALTMDDLRQDEDCLDTWFSSWLWPISLFDGINHPGNEEISYYYPTSDLVTGPDIIFFWVARMIMVGYEYEGKMPFKNVYFTGIVRDKLGRKMSKSLGNSPDPLELIDKYGADGVRMGMMLAAPAGNDILFDDALCEQGRNFCSKIWNAFRLIKGWTVDDNIQASDAAKLAVHWFESKQNEVAAEVADLFSKYRLSEALMAVYKLFWDEFSSWYLEMIKPAYGQGIDRTTYSATLCFLDNLLHLLHPFMPFITEELWQQMYERNAEEGESLMVSALSMDTYVDTAFVAQFEVVKGVISNIRSIRLQKNIAQKEPLDLQVLGENPVAEFNAVIQKMCNLSSITVVESKAEGASSFMVGTTEYAVPLGNMIDVEAEIARMEAELKHKEGFLQGVLKKLSNEKFINNAPAAVLEMERKKQADAESIISSLKESIAALKKA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y261_MYCBP
Sequence: MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRTLAADTAAMIGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGVEPDPDEMHAAGPAFTGRPGMFVRASGMALPLADDSVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTVWLGPFGGHEMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGAALAVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP
What are the official names of this protein?
Uncharacterized methyltransferase BCG_0261c.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: LPXA_AERS4
Sequence: MIDQTAIIHDTAIVHESAVIGKGVEIGPFSVIGAEVEIGDNTWVGSHVVIKGPAKLGRGNKIFQHTSIGEDCQDKKYAGERTFLEIGDNNVFRENCTVHRGTIQDQSLTKVGSGNLFMVNVHVAHDCIIGDNCIFANNATLAGHVVIGDFVIFGGLSAIHQFGRVGSHAFIGGCAALNKDVPPYVMAAGNYAKPFGVNSEGLRRRGFSAEAISAVKRAYKEIFRSGKTVEEVLPVLTEMAATEPAVQLYVDFLKDNERGIIRA
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJ006_HUMAN
Sequence: MFLHSGPARGPCTAAGRSASVRVPVQVAHELQGPDAIVFGAEVEQVHLVANELDAGRVQLLLAQGVAAAVLLVQVVMGEELGEQGHQQARGEVADGQAALLDTAKMLVAEQAVGAGQLQVGLGISNLSKSIGTSQIFLERHRSPLKLSSTLITEMSSGRLEEL
What are the official names of this protein?
Putative uncharacterized protein FLJ31958.
Protein: ALLA_BURM9
Sequence: MKTLSIEPLTRAAFAPFGDVIETQGAKQIPINLGTTMRFHDLAKIDVADEGGRPLVNLFRGQPRTLPFEVTMLERHPLGSQAFVPLTDRPYIVVVAPAGDLDASKIRAFVTSGWQGVNYAKGVWHHPLIALGEVSDFIVVDRGGDGRNLNEQNLPESLWLTDDALLAVGA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: XKDV_BACSU
Sequence: MAYEEKTDWLPDDPINEDDVNRWEKGIKDAHTDLAAHKNDMNNPHNTTKAQIGLGNVDNVQQASKTEFNEHNHDSTRHITSVERDEWNAKETPAGAQYKADQAEANAKAYTDNFAARRDNPNQVTKAQVGLGNVENVKQASLADFDAHLSNSKVHVSEGERNKWNAAQLIKLTGDDGKRIQLQDGTDILTLSSGFYCAVGQSVVNNPVEGDAAWYNYDIVEGGSGRKTIVAYQSWGSMMWIGMVHTDGEFRGWKQIATTDFIDRVQTELDLHENDKTNPHSVTKQQVGLGNVENVKQETPDGAQKKADTALNQSKDYTNSTAFITRPLNSITDANDLNLPPGTYRLDTNYMNANPVLQNQFPLNDNRTGLLIIYPSANKWATRQDWFSISTKTLYTRVAVNGTDYSGWYILENSEGSQNKADKALADAKNYVETNYTNQKLTVLTGSNAIQDARISGNDYKYGITFMDIGANNTTGYPLTYGFVKNEKHSNYRFTQYFYGNADTTSGSYDHVGTWIRHWWADSGWTAWQKISGFAHANIGTTGRQALIKGENNKIKYNRIIKDSHKLFDTKNNRFVASHAGMHLVSASLYIENTERYSNFELYVYVNGTKYKLMNQFRMPTPSNNSDNEFNATVTGSVTVPLDAGDYVEIYVYVGYSGDVTRYVTDSNGALNYFDVLELGGRNYPRV
What are the official names of this protein?
Phage-like element PBSX protein XkdV.
What is the protein family that this protein belongs to?
To B.subtilis YqcC.
Protein: LIPB_SYNJB
Sequence: MNFSGSPVQLPLLQVHLPGEVPYRTAWAWQQARLAHMIRDPQLPDGLLLLTHPAVYTLGAGADPKFLKSLSQPIGSPAIHPESPSEQEPEILRVERGGEVTYHGPGQWVGYAMLNLKRHRPDLHEYLRQLEEVVIQTLAHFGLQGERIPGLTGVWVQGRKVAAIGIKVSRWVTYHGFALNVCPDLAAFEAIVPCGIPDRPVGSLVHFCPEVTMAAVAPVLVESFCQVFGLQAQAVSLAEWLGEPRLSDKLLGESTAQTPKRK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFE3_MOUSE
Sequence: MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILDPDSFYELKSQPLFLRSSLPISLQATPTTPATLSASSSAGGSRTPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES
What is the function of this protein?
Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:16936731, PubMed:29146937).  Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:16936731).  Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:27913603).  Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:27913603).  Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (PubMed:23582324).  Required to maintain the naive pluripotent state of hematopoietic stem cell (By similarity).  TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (PubMed:30595499).  Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation and cytoplasmic retention of TFE3 inhibits browning of adipose tissue (PubMed:27913603).  In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (PubMed:16936731).  Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similarity).  It also binds very well to a USF/MLTF site.  May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).
What are the official names of this protein?
Transcription factor E3, mTFE3.
What is the protein family that this protein belongs to?
Belongs to the MiT/TFE family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:23582324, PubMed:27913603). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:23582324, PubMed:27913603).
Protein: PROA_LEGPL
Sequence: MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDVRKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKIINNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAIKTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJ4A_SCHPO
Sequence: MFFIVAAGFVIAALIAAIGMAINRFFVRRRQARAGQTKPATTRPMAEARARPGATAVPRRSPTSPQSAYVPATVYTSPIGSPRRGSVRYTHVMAHPNTTTTVSENLPEEVPPPYSPAATASNTPQNEASPAATEAVNHERPASPPPVYRPPEEMV
What are the official names of this protein?
Uncharacterized proline-rich protein C70.10.
Protein: HSPQ_ECO55
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDEHPEQPSMDELAQTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP2_ROTP5
Sequence: MAELACFCYPHLEKDSYKFIPFNSLAIKCMLTAKVDKKDQDKFYNSIVYGIAPPPQFKKRYNTNDNSRGMNFETSMFNKVAILICEALNSIKVTQSDVANVLSRVVSVRHLENLVLRKENHQDVLFHSKELLLKAVLIAIGQSKEIETTATAEGGEIVFQNAAFTMWKLTYLDHKLMPILDQNFIEYKITLNEDKPISDACVKELVAELRWQYNRFAVITHGKGHYRVVKYSSVANHADRVFATYKNNAKSGNVTDFNLLDQRIIWQNWYAFTSSMKQGNTLDVCKKLLFQKMKQEKNPFKGLSTDRKMDEVSHVGI
What is the function of this protein?
Participates in replication and packaging of the viral genome.  Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities.  The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures.  The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.
What are the official names of this protein?
Non-structural protein 2, NSP2, NCVP3, Non-structural RNA-binding protein 35, NS35.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP2 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: PCNB_SALTY
Sequence: MFTRVANFCRKVLSREESEAEQAVARPHMTIIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPDQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGSESDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMQDLQEGVIRLIGNPETRYREDPVRMLRAVRFAAKLNMHISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGNGYETYQQLREYHLFQPLFPTITRYFTENGDSAMERIIAQVLKNTDNRIRNEMRVNPAFLFAAMFWYPLLEMAQKIAQESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAFDLLELRAQVENNTELQRLAQWWAEFQASAPPEQKGMLNELDDDPAPRRRRSRPRKRAPRREGTV
What is the function of this protein?
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay.  Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
What are the official names of this protein?
Poly(A) polymerase I, PAP I.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: SPMA_BACSU
Sequence: MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGLMSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFGLGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSKTPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR
What is the function of this protein?
Involved in spore core dehydration; might be involved in the transport of something into or out of the forespore or could be required for some modification of the cortex peptidoglycan structure.
What are the official names of this protein?
Spore maturation protein A.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBL_PORAE
Sequence: MDQSVQERTRIKNERYESGVIPYAKMGYWDPDYAIKATDVLALFRVTPQPGVDPVEAAAAIAGESSTATWTVVWTDLLTACDLYRAKAYRVDPVPSSPDQYFAYIAYDIDLFEEGSIANLTASIIGNVFGFKAVKALRLEDMRIPVAYLKTFQGPATGVVVERERMNNFGRPLLGATVKPKLGLSGKNYGRVVYEGLKGGLDFLKDDENINSQPFMRWRERFLFCMEGVNRASASSGEVKGHYLNVTAATMEDMYERAEFSKEVGSIICMIDLVIGYTAIQSMAKWARKNDMILHLHRAGNSTYSRQKNHGMNFRVICKWMRMAGVDHIHAGTVVGKLEGDPLMIKGFYNTLLEPHLNINLPEGLFFEQNWASLRKVMPVASGGIHCGQMHQLIDYLGDDVVLQFGGGTIGHPDGIQAGATANRVALESMLLARNEGRDYVAQGPQILRDAAKTCGPLQTALDLWKDISFNYTSTDTADFVQTPTANV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.