PharMolix/UniProtQA huggingface dataset:
Protein: Y2144_TREDE
Sequence: MSLDKSKHEKYVQILREELVPALGCTEPIAIAYTAANLRKIMGGIPDEILIESSGNIIKNAKSVIVPNTGGMKGMEASALIGLIGGNADKGLEVLADVTEEHVKLAHEYLAKSCTKLKLMDTPASLHIRITGKLNGDTGVAELIHQHTNIVLLKKNDEIIFEKPFSLESAAGALTDRTCLNVKDILDFADTVPVDEVSPIIMRQVEYNMRVSEDGLKTSYGIETGKNILKYNQKKGDDFSVKVQAEGEVAAASDARMCGCSYPVITNSGSGNQGLAVSVPVVVYARENKISEEKLIRCLIVSNLLAIHQKTGIGRLSAYCGAVTAGAACAAAITYMKGGSYEQVCGTIVNTLGTVSGILCDGAKQSCAAKIASALDSALFSHELAMDGNFFAGGDGIVKDDIEKTIAGIGVVAAQGMHKTDEVVLQVMLKD
What are the official names of this protein?
UPF0597 protein TDE_2144.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: VL2_HPV38
Sequence: MVRARRTKRASVTDIYRGCKASNTCPPDVINKVEQSTIADKILKYGSAAVFFGGLGISTGRGTGGATGYVPLGQGPGVRVGGAPTVVRPGVIPEVIGPTELIPIDSVTPIDPTAPSIVSLTDSSAVDLLPGEVETIAEVHPGPIDPIEIDTPVVSGGRNTNAILEVADPHPPTRATVSRTQYNNPAFQIISEVIPTSGESSLADHVLVSEGSGGQQIGGTRTAEEIELQPLLSRYSFEIEEPTPPRRTSTPLQRARQQFSSLRRALYNRRLTEQVGVTDPLFFTSPSKLVRFQFDNPVFDEQVTQIFEQDIADFEEPPDRQFLDVVKLGRPTLTESAEGYVRVSRLGRRGTIRTRSGTQIGSQVHFYRDLSTINTEEPLEMQLLGEHSGDASIVQGPVESTLVDVNVTEVPEGVLTETSMDPDTFNSEDLLLDDAIEDFSGSQLVVGTPRRSTTSITVPRFQTPQNPTIYYQDIQGYHVSYPESRERPAIIYPTPDIPTVVIHVADSSGDFYLHPSLRWRRRKRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RAD51_HUMAN
Sequence: MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
What is the function of this protein?
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308).  Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308).  Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308).  Recruited to resolve stalled replication forks during replication stress (PubMed:27797818, PubMed:31844045).  Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (PubMed:24141787, PubMed:12442171).  Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (PubMed:20413593).  Also involved in interstrand cross-link repair (PubMed:26253028).
What are the official names of this protein?
DNA repair protein RAD51 homolog 1, HsRAD51, hRAD51, RAD51 homolog A.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR- dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner (PubMed:27797818, PubMed:31844045).
Protein: YHAM_ECOHS
Sequence: MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCNEILFSRAKVWNGEKWACVTIVGGHTNIVHIETHDGVVFTQQACVAEGEQESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGKWGLHIGATLEKQCARGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: RL6_NEIMA
Sequence: MSRVAKNPVTVPAGVEVKFGTEALVIKGKNGELSFPLHSDVAIEFNDGKLTFVANNSSKQANAMSGTARALVSNMVKGVSEGFEKRLQLIGVGYRAQAQGKILNLSLGFSHPIVYEMPEGVSVQTPSQTEIVLTGSDKQVVGQVAAEIRAFRAPEPYKGKGVRYVGEVVVMKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: YCF29_PORPU
Sequence: MSYNLMLVENDTVLSKAIQEYLIDQGFNVDIALNGLEAFQLANKYKFDLIISDIIMPIIDGYELLEKLRKIDKLAKIPVIFLTAKGMTKDRIKGYNMGCYGYLSKPFDPEELVSLIKNLIYRDSLNSQNLKKQNSDEIPLFQLLYLTPREKSILNLVIDGLTNKEIAVILDTSIRNVEKYVSRLLQKTNTRNRTLLVKYSIKNNLLNKI
What are the official names of this protein?
Probable transcriptional regulator ycf29.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPIKE_CVBEN
Sequence: MFLILLISLPTAFAVIGDLKCTTVSINDVDTGVPSISTDTVDVTNGLGTYYVLDRVYLNTTLLLNGYYPTSGSTYRNMALKGTLLLSTLWFKPPFLSDFTNGIFAKVKNTKVIKDGVMYSEFPAITIGSTFVNTSYSVVVQPHTTILGNKLQGFLEISVCQYTMCEYPNTICNPNLGNQRVELWHWDTGVVSCLYKRNFTYDVNADYLYFHFYQEGGTFYAYFTDTGVVTKFLFNVYLGTVLSHYYVMPLTCNSALTLEYWVTPLTSKQYLLAFNQDGVIFNAVDCKSDFMSEIKCKTLSIAPSTGVYELNGYTVQPIADVYRRIPNLPDCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLMSFIQAYSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNRRFGFTEQSVFKPQPAGVFTDHDVVYAQHCFKASTNFCPCKLDGSLCVGNGPGIDAGYKTSGIGTCPAGTNYLTCHNAAQCDCLCTPDPITSKATGPYKCPQTKYLVGIGEHCSGLAIKSDHCGGNPCTCQPQAFLGWSVDSCLQGDRCNIFANFILHDVNSGTTCSTDLQKSNTDIILGVCVNYDLYGITGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYLTNRTFMIRSCYSGRVSAAFHANSSEPALLFRNIKCNYVFNNTLSRQLQPINYFDSYLGCVVNADNSTSSVVQTCDLTVGSGYCVDYSTKRRSRRSITTGYRFTNFEPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMEEFIQTSSPKVTIDCSAFVCGDYAACKSQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSDCNKVSSRSAIEDLLFSKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYNGIKVLPPLLSENQISGYTLAATSASLFPPWSAAAGVPFYLNVQYRINGIGVTMDVLSQNQKLIANAFNNALGAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISSSLQEILSRLDALEAQAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPTKYVTAKVSPGLCIAGDRGIAPKSGYFVNVNNTWMFTGSGYYYPEPITGNNVVVMSTCAVNYTKAPDVMLNISTPNLPYFKEELDQWFKNQTSVAPDLSLDYINVTFLDLQDEMNRLQEAIKVLNQSYINLKDIGTYEYYVKWPWYVWLLIGFAGVAMLVLLFFICCCTGCGTSCFKKCGGCCDDYTGHQELVIKTSHED
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: CH602_GLOVI
Sequence: MAKMIVFDETARRALERGVNALADAVRVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDPLENTGAQLIREVASKTNDVAGDGTTTATVLAQALIREGLRNVAAGANPMSLKRGMEKTVAKLVQEIAAMAKPVEDNKTIAEVATISSGNDEEIGQMIAEAMDKVGKEGVITVEESKSLVTELDVVEGMQFDKGYVSPYFVTDTERMITDLDEPFILLTDKKISIIQDLIPVLEKVARAGRPLLIISEDLEGEALATLVVNKLRGVLNCVAVKAPGFGDRRKAMLQDIAVLTGGDVISEDIGLKLENVTIDMLGKARKVTITKDKTTIVAGTDNKAAVEKRIAQIHKQMEDTDSDFDREKLQERLAKLAGGVAVIKVGAATETELKDRKLRIEDALNATKAAVEEGIVPGGGTTLLHLTKKIDAIKAGLADDEKTGADLIARALEAPLRQIADNAGVEGSVIAQKVRELDFNIGYDAMKGEFVDMLAAGVADPAKVVRSALQNAASIAAMVLTTEVLIVDKPEKKKAGAGAPDMGGMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALT1_HUMAN
Sequence: MRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPAGDVLEPVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCNGSRSQQWLLRNVTLPEIF
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8690719, PubMed:9295285).  Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (PubMed:9295285).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 1, Polypeptide GalNAc transferase 1, GalNAc-T1, pp-GaNTase 1, Protein-UDP acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
[Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted.
Protein: MCTS1_MOUSE
Sequence: MFKKFDEKENVSNCIQLKTSVIKGIKNQLLEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
What is the function of this protein?
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition.  When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation.  Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes.  Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.  Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant.  Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation.  Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells.  May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis.  May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis.  Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity).
What are the official names of this protein?
Malignant T-cell-amplified sequence 1, MCT-1, Multiple copies T-cell malignancies 1.
What is the protein family that this protein belongs to?
Belongs to the MCTS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMY11_CAEEL
Sequence: MNSVLSNIEKLDTYILRRNEYVAESKDEPNKLNTSRKLEVTTKKNQSNNKKRPPPINKARKSLPSIFRRAEENKDSAQIITPTGSKIIGSPLYKRSKSDSFFDHAFNFDKNLGKGSFGEVVAATCRSTSKKFAIKKIPFSKLSKDQYREAYGHMNIPCHPNIVRFHQAWIDKQILHIQLEMCDKSLAAYCHGIDWLEDKELWNVFLDILQGLGHLHNNFMLHNDIKPDNIFMTKNKVCKLGDFGLISDMRSEPINNSSNKHYQSEGDGKYCSKEAINGTLSIFSDIFSFGISILEVGTNIHLPSYGTGWEPIRKWEIPEEILEPMSDELRELVKQMMDKAPTRRPTCSELMKNHVVKEKLRIRKQEVEHIPSESQFQPISYLTTESPLGSRESSCSSIDFLDHFENAEKKTPFVSKLNFDLEDDEDEYEVFSPPRTPVKKSRYQQTMPEVSPPRKIQKLFQRKNLFDE
What is the function of this protein?
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase.
What are the official names of this protein?
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1, Myt1 kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Observed in the nucleus during prophase and metaphase.
Protein: SYP_STRM5
Sequence: MRLSQFHLHTTKETPSDAELTSHRLMLRAGMIRKLASGLYTWSPLGLRVLRKVERIVREEMDRAGAVEFQIPTIQPKELWEQTGRWQKFGPQLLKIKDRKDQTFCYSPTAEEAACDFARSELSSYKQLPVNFYQIQTKFRDEIRPRFGVMRSREFLMKDAYSFHLHDECLVREYENMKSAYSRIFTRLGLDFRMVQADSGAIGGDASQEFHVIADSGEDALVFSTGSDYAANMEAAIAADPAPRAAASEAMRKVDTPTQKTCEDVAALLGINLQRTVKSVALIAGEGEAQQFVLVLVRGDHEVNEIKLAKVAGLDEQRFASEAEIAEHLGSVPGFLGPIAPAKAIRVVADREVAAMSDFVVGANEAGFHLAGVNWGRDLAEPEVADIRNVRAGDRALDGGELKIARGIEVGHVFQLGRTYARALDATVLDENGKAAVMAMGCYGIGISRVVAAAIEQNHDDAGIIWPDAMAPWQVVVCVINPKGDAAVADAATNLLQELRDAGLDAALDDRGLRPGAMFADMELIGIPHRVVVSERGLAAGTYEYRSRRASEAESLDKATLLQRLQG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_BACAA
Sequence: MGNFHATTIFAVHHNGECAMAGDGQVTMGNAVVMKHTARKVRKLFQGKVLAGFAGSVADAFTLFEMFEGKLEEYNGNLQRAAVEMAKQWRGDKMLRQLEAMLIVMDKTTMLLVSGTGEVIEPDDGILAIGSGGNYALSAGRALKQYASEHLTAKQIAKASLEIAGDICVYTNHNIIVEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP3_CRYNB
Sequence: MPSPSPEASSSMSQPGPPSRSPSPASSNPDAPEASHNKTFADLGISPELCRACASMGFKKPSDIQAEAIPHALEGKDIIGLAQTGSGKTAAFSLPILQTLWENPQPFFALVLAPTRELAYQISQQVTSLGSGIGVRTAVLVGGMDMMSQSIALSKRPHIIVATPGRLMDHLENTKGFSLKSLKYLVMDEADRLLDLDFGPIIDKILKVIPKERNTYLFSATMTTKVAKLQRASLNKPVRVEVSSKYSTVSTLLQHYLLLPLKNKDAYLLYLANELSSSSMMIFTRTVADSQRLSIILRRLGFPAIPLHGQMTQSLRLASLNKFKSGGRSILVATDVASRGLDIPLVDLVINYDMPTNSKDYVHRVGRTARAGRSGKSITLVTQYDVEILQRIESHIGKKMTSFDVDKEAVALLTDTVAKANREAALEMRESGTGGGGGKRGRDKGKRKTFGDGDDRDRDDDVVEAGVPRKKNKFTPGGKKKARK
What is the function of this protein?
ATP-dependent rRNA helicase required for pre-ribosomal RNA processing.  Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent rRNA helicase RRP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7_ACTP7
Sequence: MSLTNEQLIEAIASKSVSEIVELIAAMEEKFGVSAAAAVAAAPAAGAAAAEEKTEFDVILAEAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGISKPEAEALKKELEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SODM_ACIAD
Sequence: MTRSLKTTLILLASSVISMSALAEFKQAPLPYATNALQPAIDQQTMEIHYGKHHKAYVDNLNAQIKTYPELDKTDLIQLQKQISKYNTAVRNNGGGHFNHTFFWESLAATNKTGQPSPALVKQITQDFGSLDAFKQKFNEAASGRFGSGWAWLIVTPNGKLAVTSTPNQDNPLMDLSETKGTPLLGLDVWEHAYYLKYQNRRADYIKAFWSVVNWNKVNERYNEAIKK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PCYA_NOSP7
Sequence: MSFTSMPSLREQQHPLIRQLADCIEAAWHQHLDLSPYHLPDELGYVEGRLEGEKLTIENRCYQTPQFRKMHLELANIGNMLDILHCVMFPRPQYNLPMFGCDLVGGRGQISAAIADLSPIQLERTLPESYTTALAQLPVLNFSQPRELPEWGNIFSDFCIFVRPGSPEEEAMFLSRVREFLDIHCMQAIASHPVSVEQVTQNLAGQHNYCTKQQQNDKTRRVLEKAFGPVWAENYMTTVLFDLPT
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: FRHB_METJA
Sequence: MRWNRMNPFGSYKKVVSARSTLKEVLKKAQDGGIVSTAFIYGLENNLLDGVIVADNAGEFKAVPKVATTPEEVLEAAGTKYTVCPNISVLKSAVREYGCEKIGVVGTPCQVRAVRKLMKYPVGFRHVPDKIALIIGIFCMENFPYYGLKLIVEEHCGVKMEDVVKMDIGKGKFWVYTRWGETKAIKLKETHPYEQIACHVCTDYTAELADISTGSVGSPDGWSTVFIRTAKGEEIFNKMVEDGYLEVKPIEEVKPGLGLVEKLALQKKEKNMKEIEHRKELGLPIPY
What is the function of this protein?
Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.
What are the official names of this protein?
Coenzyme F420 hydrogenase subunit beta, 8-hydroxy-5-deazaflavin-reducing hydrogenase subunit beta, FRH.
What is the protein family that this protein belongs to?
Belongs to the FrhB family.
Protein: TXAG1_AGEOR
Sequence: MCVATCLCTFAYVLAKSDEGENLISKVEETQRGCIEIGGDCDGYLDKSYCQCCRNNGFCSCYKVPEWFGYKVGCKCSVDWNFVGWCRLKQFCPGGSQNPSLCKDPNPRRRRHGK
What is the function of this protein?
Inhibits voltage-gated calcium channels (Cav).
What are the official names of this protein?
U10-agatoxin-Ao1a, U10-AGTX-Ao1a, AgorTX_B7b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type II/III omega-agtx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PRO_ADE09
Sequence: MSGSSERELAAIVRDLGCGPYFLGTHDKRFPGFLAGDKLACAIVNTAGRETGGVHWLAFGWNPRSRTCYMFDPFGFSDRRLKQIYSFEYEAMLRRSALASSPDRCLSLEQSTQTVQGPDSAACGLFCCMFLHAFVHWPDRPMDGNPTMNLLTGVPNGMLQSPQVLPTLRRNQEELYRFLARHSPYFRSHRAAIEHATAFDKMKQLRVSQ
What is the function of this protein?
Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions.  Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors.  Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating.  Without maturation, the particle lacks infectivity and is unable to uncoat.  Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction.  Cleaves host cell cytoskeletal keratins K7 and K18.
What are the official names of this protein?
Protease, Adenain, Adenovirus protease, AVP, Adenovirus proteinase, Endoprotease.
What is the protein family that this protein belongs to?
Belongs to the peptidase C5 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Present in about 10 copies per virion.