PharMolix/UniProtQA huggingface dataset:
Protein: HPCL4_HUMAN
Sequence: MGKTNSKLAPEVLEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRLEMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDPSIVLLLQCDMQK
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
What are the official names of this protein?
Hippocalcin-like protein 4, HLP4.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: AROC_YERPN
Sequence: MAGNSIGQFFRVTTFGESHGIALGCIIDGVPPGIPITEADIQLDLDRRRPGTSRYTTQRRELDQVRILSGVFEGVTTGTSIGLMIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGVRDYRGGGRSSARETAMRVAAGAIAKKYLAQKFGVQVRGYLAQMGDVSCDLLDWDLVEQNPFFCPDASKLEPLDALMRELKKAGDSIGAKITVVAENVPVGLGEPVFDRLDADLAHALMSINAVKGVEIGDGFAVVTKRGSENRDEITPQGFQSNHAGGILGGISSGQPVVAHIALKPTSSIMVPGQTINRQGEAVEMVTRGRHDPCVGIRAVPIAEAMMAIVLMDHLLRQRAQCGDVASDVPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: CDK8_DANRE
Sequence: MGYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDRDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPLQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLSNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIRRITSEQAMQDPYFLEEPLPTSDVFAGCQIPYPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPDNSHAQGPPLKKVRVVPPTATSSGLIMTSDYQRSNPHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSHQTHRY
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.  Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPG_AKKM8
Sequence: MGNLRDIRRRIKSVKNTSQITRAMQMVASAKMRRAQDQAVKGRPYIRALAEVLYHLQDEIDTSNSPLMQTHGGADLVLLVNTDRGLCGGLNANLIKMVREQAPENAHYITIGRKLNAALAKLNERLEATWSLTDPLSLLELKPVFDFIVQKFKAEEYGRVFVAFSGFVNTMVQKPVFRQLLPIEPEPLMNMAKAGGSSLDGADAHKQFLLEPSPAALLDTILPLYVFHGLVQIVLEARASEHSARMVAMKGATENAKNIIGGLTLDYNKARQTQITNELLEITTAMRAME
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1139_DESVM
Sequence: MQQKSSSQKLINVGFGNFVVASRVVAIVNPSSSPMRRLREDARQEGRLVDATQGRKTRSIIITDSNHVILSAIQAETVGQRYTQEDAD
What are the official names of this protein?
Putative regulatory protein DvMF_1139.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: RU1C_ANOGA
Sequence: MPKYYCDYCDTYLTHDSPSVRKTHCTGRKHKDNVKFYYQKWMEEQAQHLIDATTAAYKAGKIAPNPFTAGPPKPNISIPPPTMNMPPRPGMIPGMPAGAPPLLMGPNGPLPPPMMGMRPPPMMVPTMGMPPMGLGMRPPVMSAAPPQLNPKS
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYA_CROS5
Sequence: MTTTAPFLTGNQIRDRFLQFYAQHNHQILPSASLVPEDPTVLLTIAGMLPFKPIFLGQKQPDFPRATTSQKCIRTNDIENVGRTARHHTFFEMLGNFSFGDYFKEQAIKWAWELSTKVYRLPPENIVVSVFEKDDEAFKLWEEMIGIPPQRIKRMGEKDNFWKAGPTGPCGPCSELYYDFHPELGEDNIDLEDDSRFIEFYNLVFMEYNRDAEGNLAPLQNKNIDTGMGLERMAQILQKVPNNYETDLIFPIIETAANIANIDYQKATEKTKVSLKVIGDHVRSVVHMIADGITASNTDRGYVLRRLIRRVVRHGRLIGIEGQFIKQVAETAIELSENAYPQVRERESFIKGELEREETAFLKTLERGEKLLAEIIEKTETQGQISGVDAFTLYDTYGFPLELTQEIAEESNLTVNIEEFEAEMRQQQERSKAAHETIDLTVQGSLDKLAEHIHPTAFLGYTDLQLTAKVEAVLIQGKTVDTAEAGSEVQIVLDQTPFYGESGGQIGDRGFLTGENLVIRVEDVQKESGIFVHFGRVERGSVSVNDQVTATIDRACRRQVQANHTATHLLQAALKKVVDKSISQAGSLVAFDRLRFDFNCPRAVTSEELQEIEDLINTWIAEAHETEIAVMPIETAKEKGAIAMFGEKYGSEVRVIDVPGVSMELCGGTHVKNTAEIGLFKIMSESGISSGVRRIEAVAGPAVLEYLKVRETVVKDLCDRFKIKPEEISDRITTLQSELKTTQKELEAVKQDLAVAKSDQLLTEAESIGEFKLLVSDMGEMDAKALQTAAERLQQKLGEGAVILGSIPSEGKVSLVAAFSKKVNQEKQLQAGKFIGQIAKICGGGGGGRPNLAQAGGREPSKLSEALLTAKEQLTESLK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOD_ECOLC
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGVDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDKE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: LOL2_ORYSJ
Sequence: MQSQIVCHGCRNILLYPRGAPSVCCAVCHAVSSTAPSPGMDIAHLICGGCRTLLMYTRNATSVRCSCCDTVNLVRPVSSIAHLNCGQCQTVLMYPYGAPSVKCAICNFITNTGMNTMRHLPPNGTSYTAPSTSAPTTQSQNVTVVVENPMTVDAKGKLVSNVVVGVTTGGKK
What is the function of this protein?
Putative zinc finger that may be involved in programmed cell death and defense response.
What are the official names of this protein?
Protein LOL2, Protein LSD ONE LIKE 2, OsLOL2, Putative zinc finger LOL2.
What are the subcellular locations of this protein?
Nucleus.
Protein: MBPHL_HUMAN
Sequence: MEAATAPEVAAGSKLKVKEASPADAEPPQASPGQGAGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALDTRRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLADCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVPN
What is the function of this protein?
Myosin-binding protein which plays a role in cardiac function (PubMed:28778945).  Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945).
What are the official names of this protein?
Myosin-binding protein H-like.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. MyBP family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere.
Protein: RECF_CAUVC
Sequence: MASAALLSLTLADFRSYERARLETGGRSVYLFGANGAGKTNLLEAISLLSPGKGLRGVSLAEVGRRLPGEAVGRAWAVAAEVQSGEDAPVRIGTGVEQGGAARRTVRLEGETVPPGRLADHVRPIWLTPAQDRLFLEAASERRRFFDRLVFAGEPAHAANANGYDKAQRERMRLLVDAAETGAPADAAWLTALEARLAEFGALLAQARARTLLALQAEIDGRGDRPFPLARLGLTGEWERMALEGAPFAEIELKLAQALASARARDGAAGRALTGPHRGDLAIFHVEKDRPAAECSTGEQKALILNLVLAQAARLSRAESAPNPVILLDEVAAHLDLTRRAALADELTALKLQAFLTGTDESLFDHLKGRALGVRVGDAGLTTLEDE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YC18_KLEPN
Sequence: MIVVTHTAVVQVLIHMEWIADPSIWAGLVTLVVIELVLGIDNLVFIAILAEKLPPAQRDRARITGLMLAMGMRLLLLASISWLVTLTKPLIVFHDFSFSARDLIMLFGGLFLLFKATVELNERLEGKDSDNPTQRKGAKFWAVVAQIVVLDAIFSLDSVITAVGMVDHWR
What are the official names of this protein?
Uncharacterized 18.9 kDa protein in cps region, ORF18.
What is the protein family that this protein belongs to?
Belongs to the TerC family.
Protein: CAN10_HUMAN
Sequence: MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.  May play a role in insulin-stimulated glucose uptake.
What are the official names of this protein?
Calpain-10, Calcium-activated neutral proteinase 10, CANP 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
Protein: SRTB_STAA8
Sequence: MRMKRFLTIVQILLVVIIIIFGYKIVQTYIEDKQERANYEKLQQKFQMLMSKHQEHVRPQFESLEKINKDIVGWIKLSGTSLNYPVLQGKTNHDYLNLDFEREHRRKGSIFMDFRNELKNLNHNTILYGHHVGDNTMFDVLEDYLKQSFYEKHKIIEFDNKYGKYQLQVFSAYKTTTKDNYIRTDFENDQDYQQFLDETKRKSVINSDVNVTVKDRIMTLSTCEDAYSETTKRIVVVAKIIKVS
What is the function of this protein?
Transpeptidase that anchors surface proteins to the cell wall (PubMed:11830639, PubMed:15718231, PubMed:24519933) (Probable).  Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal.  Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable) (PubMed:24519933).  This sortase recognizes an Asn-Pro-Gln-Thr-Asn (NPQTN) motif in IsdC, which is cleaved by the sortase between the threonine and aspargine residues; may only have 1 substrate in this bacterium (Probable).  May be dedicated to the process of iron acquisition during bacterial infection (Probable).
What are the official names of this protein?
Sortase B.
What is the protein family that this protein belongs to?
Belongs to the bacterial sortase family. Class B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: CSPLW_ARATH
Sequence: MAVSKLTLAATSGKSCKILLGLRLLAFSATLSAAIVMGLNKETKTFIVGKVGNTPIQATFTAKFDHTPAFVFFVVANAMVSFHNLLMIALQIFGGKMEFTGFRLLSVAILDMLNVTLISAAANAAAFMAEVGKNGNKHARWDKICDRFATYCDHGAGALIAAFAGVILMLIISAASISRLVQPNKCCSTTASPSVVP
What are the official names of this protein?
CASP-like protein 1B1, AtCASPL1B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VM3CX_DABRR
Sequence: VATSEQFNKTFIELVIVVD
What is the function of this protein?
Catalytic subunit of coagulation factor X-activating enzyme, a zinc-protease enzyme that acts in hemostasis.  Activates coagulation factor X (F10) by cleaving the Arg-Ile bond at position 234 and is also able to activate coagulation factor IX (F9) and protein C (PROC) by specific cleavage of Arg-Ile and Arg-Val bonds (By similarity).
What are the official names of this protein?
Coagulation factor X-activating enzyme heavy chain, Coagulation factor X-activating enzyme chain alpha, RVV-X heavy chain, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIId sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EFG_CAUVN
Sequence: MPRTHKIEDYRNFGIMAHIDAGKTTTTERILYYTGKSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWNDKRLNIIDTPGHVDFTIEVERSLRVLDGAVTVLDGNAGVEPQTETVWRQADKYKVPRIVFVNKMDKIGADFDKSVESIRDRLGAKAVPIQFPIGSESNLKGLVDLVRMKAVVWDNDGLGASYRDEEIPADLMDKAVEARAYLVENAVELDDDAMEAYLGGEEPSIETIKKCIRKAVLTGAFYPILCGSAFKNKGVQPLLDAVVDYLPSPVDIPPTKGIDFKTEEETTRKASDEEPLSVLAFKIMDDPFVGSLTFCRIYSGKMETGMSLLNSTRDKRERVGRMLLMHSNNREDIKEAYAGDIVALAGLKETRTGDTLCDPLKSPVILERMEFPAPVIEIAVEPKSKADQEKLGVALQKLAAEDPSFTVSTDFESGQTILKGMGELHLDIKIDILKRTYKVEANIGAPQVAYRESLGRKVDIDYTHKKQTGGTGQFARVMITFEPGEPGSGFVFESAIVGGAVPKEYIPGVQKGLESVKDSGLLAGFPLIDFKATLTDGKYHDVDSSVLAFEIASRAAFKELREKGAPKLLEPIMKVEVVTPEEYLGSVIGDLNSRRGMIQGQDMRGNATVVNAYVPLANMFGYVNTLRGMSQGRAQFSMVYDHYDPVPQHVADEVIKKYA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_RHOP5
Sequence: MNIRSNPDTTRPAVTTGALPSSQKIYVTPDAAPDLRVPLREIILSKEAAEPNLPVYDTTGPYTDPAITIDVNAGLKRPRTQWVLERGGVEQYQGREIKPIDNGNVSGEHAAAAFKAYHQPLRGVGDSPITQYEFARKGIITKEMIYVATRENLGRKQQLERAEAALADGESFGAAIPAFITPEFVRDEIARGRAIIPANINHGELEPMIIGRNFLTKINANIGNSAVTSSVEEEVDKMVWAIRWGADTVMDLSTGRNIHTTREWILRNAPIPIGTVPIYQALEKCDGDPVKLTWELYKDTLIEQCEQGVDYFTIHAGVRLAYIHLTANRVTGIVSRGGSIMAKWCLAHHQESFLYTHFDEICDLMRKYDVSFSLGDGLRPGSIADANDRAQFAELETLGELTKIAWDKGCQVMIEGPGHVPLHKIKINMDKQLKECGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPDRNDVKVGVITYKIAAHASDLAKGHPAAQLRDDAVSRARFDFRWQDQFNLGLDPDTAKAFHDETLPKDAHKVAHFCSMCGPKFCSMKITQDVRDYAAGLGDNEKAALYPAGHVGMTISGVIEDGMAQMSAKFRDMGEELYLDAEKVKESNRALS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: HSCB_YERPY
Sequence: MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLGNEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRVAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQQVEQLEERLFDDFA
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: CBPA_ECOK1
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFNRQFHHGDGQSFNAEDFDDIFSSIFGQHARQSRQRPATRGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGTKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CC127_MOUSE
Sequence: MNNLNDPPNWNIRPNARADGGDGSKWNYALLVPMLGLAAFRWIWSRESQKEIEKARKAYHQRTAAFQQDLEAKYHAVISEHRRAVAQLSLELEKEQNRTSSFREALISQGRKLAEEKKLLEQERAQIKQEKSRLQPLRNVYLSCLQEEDDWQRRAQHVLKEVGEALEERQNIYCSLIIPRSARLELEKSLLVRTSVDPVAADLEMAAGLSDIFKHDKHCGDVWNTNKRQNGKLMWMYLKYWELLVELKKFKKVEKVILEK
What are the official names of this protein?
Coiled-coil domain-containing protein 127.
Protein: HAP2_HAEIF
Sequence: MKKTVFRLNFLTACISLGIVSQAWAGHTYFGIDYQYYRDFAENKGKFTVGAQNIKVYNKQGQLVGTSMTKAPMIDFSVVSRNGVAALVENQYIVSVAHNVGYTDVDFGAEGNNPDQHRFTYKIVKRNNYKKDNLHPYEDDYHNPRLHKFVTEAAPIDMTSNMNGSTYSDRTKYPERVRIGSGRQFWRNDQDKGDQVAGAYHYLTAGNTHNQRGAGNGYSYLGGDVRKAGEYGPLPIAGSKGDSGSPMFIYDAEKQKWLINGILREGNPFEGKENGFQLVRKSYFDEIFERDLHTSLYTRAGNGVYTISGNDNGQGSITQKSGIPSEIKITLANMSLPLKEKDKVHNPRYDGPNIYSPRLNNGETLYFMDQKQGSLIFASDINQGAGGLYFEGNFTVSPNSNQTWQGAGIHVSENSTVTWKVNGVEHDRLSKIGKGTLHVQAKGENKGSISVGDGKVILEQQADDQGNKQAFSEIGLVSGRGTVQLNDDKQFDTDKFYFGFRGGRLDLNGHSLTFKRIQNTDEGAMIVNHNTTQAANVTITGNESIVLPNGNNINKLDYRKEIAYNGWFGETDKNKHNGRLNLIYKPTTEDRTLLLSGGTNLKGDITQTKGKLFFSGRPTPHAYNHLNKRWSEMEGIPQGEIVWDHDWINRTFKAENFQIKGGSAVVSRNVSSIEGNWTVSNNANATFGVVPNQQNTICTRSDWTGLTTCQKVDLTDTKVINSIPKTQINGSINLTDNATANVKGLAKLNGNVTLTNHSQFTLSNNATQIGNIRLSDNSTATVDNANLNGNVHLTDSAQFSLKNSHFSHQIQGDKGTTVTLENATWTMPSDTTLQNLTLNNSTITLNSAYSASSNNTPRRRSLETETTPTSAEHRFNTLTVNGKLSGQGTFQFTSSLFGYKSDKLKLSNDAEGDYILSVRNTGKEPETLEQLTLVESKDNQPLSDKLKFTLENDHVDAGALRYKLVKNDGEFRLHNPIKEQELHNDLVRAEQAERTLEAKQVEPTAKTQTGEPKVRSRRAARAAFPDTLPDQSLLNALEAKQAELTAETQKSKAKTKKVRSKRAVFSDPLLDQSLFALEAALEVIDAPQQSEKDRLAQEEAEKQRKQKDLISRYSNSALSELSATVNSMLSVQDELDRLFVDQAQSAVWTNIAQDKRRYDSDAFRAYQQQKTNLRQIGVQKALANGRIGAVFSHSRSDNTFDEQVKNHATLTMMSGFAQYQWGDLQFGVNVGTGISASKMAEEQSRKIHRKAINYGVNASYQFRLGQLGIQPYFGVNRYFIERENYQSEEVRVKTPSLAFNRYNAGIRVDYTFTPTDNISVKPYFFVNYVDVSNANVQTTVNLTVLQQPFGRYWQKEVGLKAEILHFQISAFISKSQGSQLGKQQNVGVKLGYRW
What is the function of this protein?
Probable protease; promotes adherence and invasion by directly binding to a host cell structure.
What are the official names of this protein?
Adhesion and penetration protein autotransporter.
What are the subcellular locations of this protein?
[Adhesion and penetration protein autotransporter]: Periplasm. SUBCELLULAR LOCATION: [Adhesion and penetration protein]: Secreted. Cell surface. SUBCELLULAR LOCATION: [Adhesion and penetration protein translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Protein: STK4_XENLA
Sequence: METVQLRNNPRRHLKKLSEESLNKQPEEVFDVLEKLGEGSYGSVYKASHKETSQIVAIKQIPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEFCGGGSVSDIIRLRKQTLNEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLSCEGTAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAEIHPMRAIFMIPSNPPPTFRKPELWSKDFVDFINLCLVKNPELRSSATELLQHPFIKAAKGESILRHLLNAAQDEKLKRTELKQREVEPEEKENVNEDEVDVGTMVQAGGKDLNTMKELGMMSEGADGTMVEKDKLETQMGTMLINDEDEEEETGTMKQCTEPAQQAKPSFLEYFEQKENQFGTPEKTSPTSTDPSEWKIPLNGDYSFLKDWSVAEVQLKLNSLDPMMEREIEEIHHKYQAKRQPILEAIESKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz.  Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between nucleus and cytoplasm.
Protein: INSI3_ECOLI
Sequence: MRRTFTAEEKASVFELWKNGTGFSEIANILGSKPGTIFTMLRDTGGIKPHERKRAVAHLTLSEREEIRAGLSAKMSIRAIATALNRSPSTISREVQRNRGRRYYKAVDANNRANRMAKRPKPCLLDQNLPLRKLVLEKLEMKWSPEQISGWLRRTKPRQKTLRISPETIYKTLYFRSREALHHLNIQHLRRSHSLRHGRRHTRKGERGTINIVNGTPIHERSRNIDNRRSLGHWEGDLVSGTKNSHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGVKVYFCDPQSPWQRGTNENTNGLIRQYFPKKTCLAQYTQHELDLVAAQLNNRPRKTLKFKTPKEIIERGVALTD
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase InsI for insertion sequence element IS30C.
What is the protein family that this protein belongs to?
Belongs to the transposase IS30 family.
Protein: OBG_CELJU
Sequence: MKFVDEAPISVEAGKGGNGALSFRKEKFVAKGGPDGGDGGDGGSVFLVADENLNTLIDYRFQPKYRAEDGEKGASKNCTGAKGDDLLLPVPVGTTVIDMDTEEVFGDLTEHGQRLKVAQGGFHGLGNTRFKSSTNRVPRKTTPGTEGEKRNLKLELKVLADVGMLGLPNAGKSSFIRAVSSAKPKVADYPFTTLVPNLGVVKVQQHRSFVIADIPGLIEGASEGAGLGVRFLKHLTRCRLLLHMVDMAPVDGSNPVDNVRVIANELQKFSPTLSNRDRWLLLNKIDLLPIDEVEARCAAVVKELEWTGPVFRVSALKHEGTAELSGKIMDHLEAIWEEERENPDARALELERQNQMAAEARERIEELREARRQARLAAGEDDDFNEDDYDVEVIYVNY
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.