PharMolix/UniProtQA huggingface dataset:
Protein: HJC_METTH
Sequence: MVKNGTRGERDLVKLLWEKGFAAMRAPASGGATKKPLPDIIAGNGEIYLAIEVKTTARERIYIDSEKIGALLRFSDIFGARPYIGIKFRYRDWIFLSPGDLELTPSSNYRLDLDIALERGRDLDEVTGNHRQTRLR
What is the function of this protein?
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination.  Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.  Cleaves both mobile and immobile junctions.  Converts a synthetic Hj to nicked duplex products.  Binds a variety of branched DNA structures but linear dsDNA poorly; cleaves only 4-way junctions.  Confers UV and mitomycin C resistance to E. coli cells lacking the endogenous Hj machinery RuvABC.
What are the official names of this protein?
Holliday junction resolvase Hjc, Hjc.
What is the protein family that this protein belongs to?
Belongs to the Holliday junction resolvase Hjc family.
Protein: T23O_DROPS
Sequence: MSCPYAGNGNDHDDAAVPLSTEVGKIYGEYLMLDKLLDAQCMLSTEDKRPVHDEHLFIITHQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFGGDEQALSAIRSSEYEPSLLELVQRWLERTPGLEESGFNFWKKFQQSVDQFLAAQVEIAMEEPVEQAKNYRLMDIEKRREVYHSIFDPAVHEALVKRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKLVHKSV
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Protein vermilion, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: PHNC_HALSA
Sequence: MSNITVTNLHKSYGDVDALEDVSFEILDGEFVVILGESGAGKSTLLRCLNGLTEPTTGSVKIDGEPVNGPRDDVGMIFQQHNIIEEMTAYTNALSGSLNRTSLVRSLFQWNDREEKLDALRALDTVGLLDDAEQRAGRMSGGQQQRVGISRALVQDPNLLLADEPVASLDPASAESVMGYIKDAADQHDLTTLASLHQVNLAREFGQRFIGMKDGRVIFDGYRDDLTFDVIDDIYGNIQTDAIRTGDDANADVAPTTSSDGGTDAAGGPDQQPASDPHLS
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CLPB_THET8
Sequence: MNLERWTQAAREALAQAQVLAQRMKHQAIDLPHLWAVLLKDERSLAWRLLEKAGADPKALKELQERELARLPKVEGAEVGQYLTSRLSGALNRAEALMEELKDRYVAVDTLVLALAEATPGLPGLEALKGALKELRGGRTVQTEHAESTYNALEQYGIDLTRLAAEGKLDPVIGRDEEIRRVIQILLRRTKNNPVLIGEPGVGKTAIVEGLAQRIVKGDVPEGLKGKRIVSLQMGSLLAGAKYRGEFEERLKAVIQEVVQSQGEVILFIDELHTVVGAGKAEGAVDAGNMLKPALARGELRLIGATTLDEYREIEKDPALERRFQPVYVDEPTVEETISILRGLKEKYEVHHGVRISDSAIIAAATLSHRYITERRLPDKAIDLIDEAAARLRMALESAPEEIDALERKKLQLEIEREALKKEKDPDSQERLKAIEAEIAKLTEEIAKLRAEWEREREILRKLREAQHRLDEVRREIELAERQYDLNRAAELRYGELPKLEAEVEALSEKLRGARFVRLEVTEEDIAEIVSRWTGIPVSKLLEGEREKLLRLEEELHKRVVGQDEAIRAVADAIRRARAGLKDPNRPIGSFLFLGPTGVGKTELAKTLAATLFDTEEAMIRIDMTEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQILDDGRLTDSHGRTVDFRNTVIILTSNLGSPLILEGLQKGWPYERIRDEVFKVLQQHFRPEFLNRLDEIVVFRPLTKEQIRQIVEIQLSYLRARLAEKRISLELTEAAKDFLAERGYDPVFGARPLRRVIQRELETPLAQKILAGEVKEGDRVQVDVGPAGLVFAVPARVEA
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_CHLMU
Sequence: MALKIRLRQQGRKNHVVYRLVLADVESPRDGKYIELLGWYDPHSEQNYQLKSERIFYWLNQGAELTEKAGALVKQGAPGVYAELMAKKNARRAVVRQKRRAYRQRLAARRAEAAAK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: KAD_VIBVY
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDEIILGLIKERIAQEDCAKGFLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDKEETVRARLGVYHSQTAPLIEYYGKEAAESNTKYLKFDGTKQVAQVSADIEKALA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_STUS1
Sequence: MNLHEYQGKQLFAEYGLPVSKGYAVDSPKEAAEACDKIGGTQWVVKAQVHAGGRGKAGGVKLVRSKDEARAFAQQWLDKRLVTYQTDANGQPVSKILVEACTDIDKELYLGAVVDRASRRIVFMASTEGGVDIEKVAHDTPEKILKATIDPLVGAQPFQARELAFQLGLKGDQVKQFVHIFVGLAQLFQDYDLALLEVNPLVIKTDGNLHCLDAKINIDSNAIYRQPKLRDMADPSQDDPREAHAAKWELNYVALDGNIGCMVNGAGLAMGTMDIVNLHGGAPANFLDVGGGATEERVTEAFKIILSDSNVAAVLVNIFGGIVRCDMIAEGIIGAVREVGVKVPVVVRLEGNNADLGAKMLSESGLNIIGANSLTDAAIQVVKAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: CAPSD_MUMIM
Sequence: MAPPAKRAKRGWVPPGYKYLGPGNSLDQGEPTNPSDAAAKEHDEAYDQYIKSGKNPYLYFSAADQRFIDQTKDAKDWGGKVGHYFFRTKRAFAPKLATDSEPGTSGVSRAGKRTRPPAYIFINQARAKKKLTSSAAQQSSQTMSDGTSQPDGGNAVHSAARVERAADGPGGSGGGGSGGGGVGVSTGSYDNQTHYRFLGDGWVEITALATRLVHLNMPKSENYCRIRVHNTTDTSVKGNMAKDDAHEQIWTPWSLVDANAWGVWLQPSDWQYICNTMSQLNLVSLDQEIFNVVLKTVTEQDSGGQAIKIYNNDLTACMMVAVDSNNILPYTPAANSMETLGFYPWKPTIASPYRYYFCVDRDLSVTYENQEGTIEHNVMGTPKGMNSQFFTIENTQQITLLRTGDEFATGTYYFDTNPVKLTHTWQTNRQLGQPPLLSTFPEADTDAGTLTAQGSRHGATQMEVNWVSEAIRTRPAQVGFCQPHNDFEASRAGPFAAPKVPADVTQGVDREANGSVRYSYGKQHGENWAAHGPAPERYTWDETNFGSGRDTRDGFIQSAPLVVPPPLNGILTNANPIGTKNDIHFSNVFNSYGPLTAFSHPSPVYPQGQIWDKELDLEHKPRLHITAPFVCKNNAPGQMLVRLGPNLTDQYDPNGATLSRIVTYGTFFWKGKLTMRAKLRANTTWNPVYQVSVEDNGNSYMSVTKWLPTATGNMQSVPLITRPVARNTY
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1.  The capsid encapsulates the genomic ssDNA.  Capsid proteins are responsible for the attachment to host cell receptors.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.  Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s).  VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).
What are the official names of this protein?
Capsid protein VP1, Coat protein VP1.
What is the protein family that this protein belongs to?
Belongs to the parvoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ASQJ_EMENI
Sequence: MGYPKAFTSSDSEPEPDLSRDLGNPVMGNPGVVSRSSSTVAQHSVRNNPTGPDGRLAGLWNARALLRFPAEVNGVRLDFKSVSSRRPTSRLSLLPYSLCSICPSSQATMTSKDHVKSQIPRLSAINDLHKIWPTVEEHGAAIIESFLSLDIVRRLNEEVDPFVKIEPIPAAKTKDHPNHVLSTTTRLVNVLAPISKAYREDVLNSKVLHRICSDAFHVYGDYWVLMGAVMELAPSNPAQPLHRDMRFSHPIVEYLKPDAPATSINFLVALSPFTAENGATHVILGSHKWQNLSNVSMDATVRALMNPGDALLITDSTIHCGGAETTGTETRRLLTITMGISQLTPLESNLAVPRPVIESLTPLAQRLLGWASQRSAAPRDIGLLTIRGNSIEKTMNLKAEQPLHDDEAEPLCRETI
What is the function of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934, PubMed:26553478).  Within the pathway, the iron/alpha-ketoglutarate-dependent dioxygenase asqJ acts as a (-)-cyclopenine synthase that converts 4'-methoxycyclopeptin into 4'-methoxydehydrocyclopeptin through dehydrogenation to form a double bond between C-alpha and C-beta of the O-methyltyrosine side chain (PubMed:25251934, PubMed:26553478).  AsqJ is a very unique dioxygenase which is capable of catalyzing radical-mediated dehydrogenation and epoxidation reactions sequentially on a 6,7-benzo-diazepinedione substrate in the 4'-methoxyviridicatin biosynthetic pathway (PubMed:25251934).  AsqJ is also capable of converting cyclopeptin into dehydrocyclopeptin (PubMed:25251934).  The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin.  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, (-)-cyclopenine synthase, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqJ, Aspoquinolone biosynthesis protein J.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: NUOI_CAMJE
Sequence: MKNYYLVDEKRKTPVSTWEKISQALRRSVKLELFVGLFVMMRELLKRNNSATIKYPFEKVKLDNRYRAVHRLMRFIESENERCIGCGLCEKICISNCIRMETSLDENGRKKVENYSINLGRCIYCGFCAEVCPELAIVHGTEYENAAEQRSYFGYKQDFLTPIDKLKNQVEFEGAGSLRKDANLWVKKTPNYYDVMIERALENQNTQEQGENK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KP86R_ASFB7
Sequence: MGINQSQHSMGVNQSHHFMGVNQSHHFMGINQSQHSMGVNQHIIGDSYLISCMVVAPCCLKACMVLAPCCLKACMVLAPCCLKAAR
What are the official names of this protein?
Uncharacterized protein KP86R/DP86L.
Protein: YBEY_LACJO
Sequence: MNNLDISFNDEVNFLKDSDKDWITWISNLLLSAKKEIHKENTQEMSINFVSSKKIHEINKKYRGKDRPTDVISFAIEDGLDEDFISAFSDDPDFVEDIGDLFLCPEVIKRHSVEYETGFNREFGYTLVHGYLHLNGYDHIEDDEAKVMFGIQGKVLREYGLPLHPDQENHGKQIH
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_TRIV2
Sequence: MTQRIIGLTGGIATGKTTVANYLASAHHLPIFDADIYARDAVSLGSPILDAIAGRYGKEILLPDGSLNRPKLGEIIFQNQDERHWLESLIHPYVRDRFLKAIAESTSPILVLVIPLLIEVQMTNLVTEIWVVICSESQQLQRLMERNHLTLEQAQARINSQLSLKEKAAIADVVLDNSSSLESLLKQVDIALNFEL
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUOX1_PIG
Sequence: MGFRLALAWTLLVGPWMPMGARNSISWEVQRFDGWYNNLMEHKWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTAMRGPAGQASLRNRTVLGVFFGYHVLSDLVSIEKPGCPAEFLNIHIPPGDPVFDPHKSGDVVLPFQRSRWDPNTGQSPSNPRDLTNEVTGWLDGSAIYGSSHSWSDELRSFSGGQLASGPDPAFPRQAQDPLFMWTPPDPATGQRGPQGLYAFGAEQGNREPFLQALGLLWFRYHNLCAQKLAREHPLWGDEELFQHARKRVIATYQSITMYEWLPSFLRKMPQEYTGYRPFLDPSISPEFLAASEQFFSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPNLQRAEDVDALLLGMASQIAEREDHMVVEDVQDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARARLGLPPVTRWQDINPALSRSDGIVLEATAALYNQDLSRLELLPGGLLESYGDPGPLFSTIVLDQFVRLRDGDRYWFENTKNGLFSEKEIAEIRNTSLRDVLVAVTNMTPGALQPNVFFWHAGDPCPQPRQLSTKDLPACAPLIMRDYFKGSGFGFGVTIGTLCCFPLVSLLSAWIVAQLRRRNFKRLQVQNRQSIMCEKLVGGMKALEWQGRKEPCRPVLVHLQSGQIHVMDGRLSVLRTIQLRPPQQVNLILSSNHGRRTLLLKIPKEYDLVLMFDLEEERQVMVENLQSALKESGLSFQEWELREQELMRAAVTREQRSHLLETFFRHLFSQVLDIDQADAGALPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLTEVVESMFREAGFQDKQELTWEDFHFMLRDHDSELRFTQLCVKGVEVPEVIKDLCRRASYISQEKLCPSPRVSAHCPRSNVDVEVELTPWKLQCPTDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFVENYRRHIGCLAVFYTIAGGLFLERAYYYAFAAHHMGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDNGSEFPQKYYWWFFQTVPGLTGVMLLLILAIMYVFASHHFRRCSFRGFWLTHHLYILLYMLLIIHGSFALIQLPRFHIFFLVPALIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTDDNCAKYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
What is the function of this protein?
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO.  Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa.  May have its own peroxidase activity through its N-terminal peroxidase-like domain.
What are the official names of this protein?
Dual oxidase 1.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the peroxidase family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.
Protein: RS8_BRASO
Sequence: MSTHDPISDLITRIRNAQMRSKSKVTTPGSKMRASVLEVLKSEGYIRGYATMEHPSGRSEIEIELKYFDGEPVIREIERVSKPGRRVYTSVKNLPRVNNGLGISVLSTPKGIMADHSARDANVGGEVLFTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FOLD_BURPS
Sequence: MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SYT_RHORT
Sequence: MVAISLPDGSVRSYEGPVTGRQIAEDIGPGLAKAALAVTIDGTMKDLSVPITTDASVSLITARDAAALELLRHDAAHVMAQAVQELYPGTQVTIGPAIENGFYYDFARAEPFTPEDLERIEERMREIVGRDLPIVREVWERDEAIAYFTKLGETYKAELITGLPANEDVSVYRQGDWLDLCRGPHLPSTGKLGTAFKLMKLAGAYWRGDSRNPMLQRIYGTAWPDRKQLDAYLTMLAEAEKRDHRRVGQEMDLFHLQEEAQGAVFWHPKGWTVYRTLQNYMRRRLDLAGYVEVNTPMLVDRALWEKSGHWEKFRQNMFISEAEDKLLAMKPMNCPCHIQIFKQGIKSYRDLPLRMAEFGACHRNEASGALHGLMRVRAFVQDDAHIFCTEDQIVSETQAFCDLLKSVYRDLGFTEIKVKFSDRPEVRAGSDETWDKAEAALREATDAAGLEWTLNPGEGAFYGPKLEFVLRDAIGRDWQCGTLQVDFVLPERLGADYVGEDGDKHRPVMLHRAILGTFERFMGILIENCAGRFPFWLAPVQVVVATITSDADDYARTVLAALKAKGLRAVADLRNEKINYKVREHSLAKVPVMLVVGRKEAETGGVALRRLGGQSQEVLALDEAIATLANESVAPDLRAAPQG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMEM9_HUMAN
Sequence: MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
What is the function of this protein?
Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053).  By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053).  TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568).  In the liver, involved in hepatic regeneration (PubMed:32380568).
What are the official names of this protein?
Proton-transporting V-type ATPase complex assembly regulator TMEM9, v-ATPase assembly regulator TMEM9, Dermal papilla-derived protein 4, Transmembrane protein 9, Protein TMEM9.
What is the protein family that this protein belongs to?
Belongs to the TMEM9 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
Protein: RL24_SODGM
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKAIVEGINLIKKHQKPVPAMNQPGGIVEKEAAIDLSNLAIFNAAASKADRVGFKIEDGKKVRVFKSNGETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RK28_CYAM1
Sequence: MSRVCPLTLKKCNHAFRVTYSHKRNHRRQFVNLQKKRIFINNEWVVLKISTKAIKTLKSKTLKSKTFSNARLLHL
What are the official names of this protein?
50S ribosomal protein L28, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: REDX2_CATRO
Sequence: MEKQVEIPEVELNSGHKMPIVGYGTCVPEPMPPLEELTAIFLDAIKVGYRHFDTASSYGTEEALGKAIAEAINSGLVKSREEFFISCKLWIEDADHDLILPALNQSLQILGVDYLDLYMIHMPVRVRKGAPMFNYSKEDFLPFDIQGTWKAMEECSKQGLAKSIGVSNYSVEKLTKLLETSTIPPAVNQVEMNVAWQQRKLLPFCKEKNIHITSWSPLLSYGVAWGSNAVMENPVLQQIAASKGKTVAQVALRWIYEQGASLITRTSNKDRMFENVQIFDWELSKEELDQIHEIPQRRGTLGEEFMHPEGPIKSPEELWDGDL
What is the function of this protein?
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e. g.  tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine.  Catalyzes the second oxidation step of the unstable intermediate product resulting from the reaction triggered by the geissoschizine oxidase (GO) in the stemmadenine biosynthesis process from 19E-geissoschizine.
What are the official names of this protein?
Protein REDOX 2.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: DMPD_PSEUF
Sequence: MNAPQNSPEIGREIIAAGIRTNLHDSGAGFPLMMIHGSGPGVTAWANWRLVMPELAKSRRVIAPDMLGFGYSERPADAQYNRDVWVDHAVGVLDALEIEQADLVGNSFGGGIALALAIRHPERVRRLVLMGSAGVSFPITEGLDAVWGYNPSFAEMRRLLDIFAFDRNLVNDELAELRYQASIRPGFHESFAAMFPAPRQRWVDGLASAEAAIRALPHETLVIHGREDQIIPLQTSLTLADWIARAQLHVFGQCGHWTQIEHAARFASLVGDFLAEADAAAIS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxymuconate semialdehyde to 2-hydroxypent-2,4-dienoate.
What are the official names of this protein?
2-hydroxymuconate semialdehyde hydrolase, HMSH, 2-hydroxymuconic semialdehyde hydrolase.
What is the protein family that this protein belongs to?
Belongs to the DmpD/TodF/XylF esterase family.
Protein: IDI_SHIB3
Sequence: MQTEHVILLNAQGVPTGTLEKYAAHTADTLLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGERNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTNSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQAANSEARKLLSAFAQHN
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.