PharMolix/UniProtQA huggingface dataset:
Protein: SOSSC_BOVIN
Sequence: MAANPSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASIALSRPALNKDFRDHAEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE
What is the function of this protein?
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint.  The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability.  Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).
What are the official names of this protein?
SOSS complex subunit C, INTS3- and NABP-interacting protein, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, SOSS-C, Single-stranded DNA-binding protein-interacting protein 1, SSB-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOSS-C family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear foci following DNA damage.
Protein: A28_LSDVN
Sequence: MNAITIFFIILSTVAVCIIIFQLYSIYLNYDNIKEFNSAHSAFEFSKSVNTLSLDRTIKDPNDDIYDPKQKWRCVKLDNDYVSVSMFGFKSNGSEIRKFKNLESCIDYTFSQSTHSDIKNPCILQNGIKSKECIFLKSMF
What is the function of this protein?
Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).
What are the official names of this protein?
Envelope protein A28 homolog, Protein LSDV118.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A28 protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Note=Component of the intracellular mature virion (IMV) membrane.
Protein: S46A3_PONAB
Sequence: MKILFVEPAIFLSAFAMTLTSPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAVIDFLLGLVTGLTGLSSGYFIRELGFGWSFLIIAASLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTTITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMVMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGILFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDRAC
What are the official names of this protein?
Solute carrier family 46 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SLC46A family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL9_FRASN
Sequence: MKLVLTQEVPGLGSPGDIVDVADGYGRNYLVPRRYAILATRGAERQVAQIKRARDARAVRDLDHAKEIAGQLSGLSVRLVSRAGKEGRLFGSVTAADVVSAVTDAGGPALDRRRVELSTPIKSLGSHTVAVHLHPEVSAKLTVQVTSA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ASSY_BURCM
Sequence: MSTILESLPTGQKVGIAFSGGLDTSAALHWMKLKGAVPYAYTANLGQPDEDDYDAIPKRAIEYGAAGARLIDCRAQLVAEGIAALQSGAFHITTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQTFIDELGGRAEMSEFMNQAGFAYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIAAEEVTVRFEAGQPVALNGVEYKDPVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAITGEVKIELRRGNDYSILSTKSPNLTYQPERLSMEKVASTFSPRDRIGQLTMRNLDITDTRDKLRVYSQVGLLTPGESSALPQIKGDSDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y319_RICBR
Sequence: MKEQDNLSISQELYGTILINLKSIVQNIFPLEYNKQEITISYIVEQIASSGSIQKNSDYPELDEEIEEINQAIIDYCKYKEIPKEEENNIYKKTSELIKDGFLKNIEQTTKLEPTTELEKKYLDKLNQATSSDEKKIIIDQHKLEIEAFNKQIAQDFQKKQEDLRGNREITNVEEHKLVKEGIVTKEEIEPYLSNYPLLNTLVEYIYLDDDQDIPLVKKLFEIARNFYPNNSTQELKELMELSYKKVNDLVGTNSSNILELLNHKQISFADINNVESEELHKINEIKIKSNFKILDCVISGDCRVTLKKLIETGKIESFDKKELELVVALFEKDADTLNKHQETKLSSKVGKLLLTFHASKAYKLDDLMQFINIIDVAEELLFTATYYQNINIIKQIIETKIEISSSTLIKALYINFTSDNKEILDYLLSFKGLNINEHDENGGTLLDYAITFNKLDIVKKLLSHENIEVNKKNIYGFTILEQAINDDKLEIVKLLLSCKSLEINQKNQYQTTPLQQAINGDKLEIVKLLLSHPDIKFNEKDQLGYTSLDWVIICNKLEIFKVLMPHLDINQKNQDGYTPLEWSIYNSYEVFQTLLLRPDINVNEENQHGLTPLQLAIIDHNDQMIQALLSHKNIEVSEKNQYGTPLELVINNSNDTALKLLLSHPKINLNKTEIAEILRLHEAKLKEEVQDDSVPISNIELDTSVLGGLEEDQESYGL
What are the official names of this protein?
Putative ankyrin repeat protein RBE_0319.
Protein: MK07_RAT
Sequence: MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSGPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPVPAPAPAPAPTPKPSSAQPTSPPNGPVSQSTAPLQPAGSIPGPASQPVCPPPGPVPQPAGPVPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP
What is the function of this protein?
Plays a role in various cellular processes such as proliferation, differentiation and cell survival.  The upstream activator of MAPK7 is the MAPK kinase MAP2K5.  Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C.  EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway.  May have a role in muscle cell differentiation.  May be important for endothelial function and maintenance of blood vessel integrity.  MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.  Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity).  Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Protein: KRFB_CATAU
Sequence: MSCYDLCRPCGPTPLANSCNEPCVRQCQDSRVIIEPSPVVVTLPGPILSSFPQNTAVGSTTSAAVGSILSEEGVPINSGGFNLSGLGGHYYSRRCLPC
What are the official names of this protein?
Feather beta keratin, F-ker.
What is the protein family that this protein belongs to?
Belongs to the avian keratin family.
Protein: OAZ2_HUMAN
Sequence: MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers.  Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240).  Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).
What are the official names of this protein?
Ornithine decarboxylase antizyme 2, AZ2, ODC-Az 2.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMM_HAHCH
Sequence: MSEKVCIGKIVGVYGVKGWLKVRSFTSPPENMLRYANWELVREDGNRSSAKLRSGKPQGKGIVIALAGVDDRNLAKSYVGCQIEIESSELPALEEGEYYWRQLEGLTVFTSEGVNIGRVSHLIETGANDVLVVIGSAESIDKRERLIPYLPGQFIENIDLDKNLMVVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO6_METAC
Sequence: MVKEKYTRFERARIVGARALQIAMGAPVLVDDDGRLDPLGVAIAELKAEIIPITVKRKKS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_METVO
Sequence: MAKFIMVAGTASNSGKTVMVSGICRMLANKGYKVAPFKSENMSLNSRVSVEDGEIAVAQYTQSVAAKVEPSTHFNPVLLKPKGNFTSQVIIHGKPYKNLDYNEYRNEKDYCIEKIKESLDYLNKNYDYVIMEGAGSCCEINLLEDDIANLRVAEMANADVLLVSDIDRGGVFASLYGTVELLPENWRKLIKGFIINKFRGNADVLTDGFKKITELTNIDVAGLIPYDES
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: SMG_SHEAM
Sequence: MFDILMYLFENYVQNDLEVDMLVDEDQLKKELALAGFRQTEIIKALNWLEHLADLRDSEQPYLCHHEQHSFRVYTPEEMERLDVECRGFLMFLEQIKVLNVEAREMVIDRVMDLDESSLTLDDLKWVIMMVLFNAPGQEMAYNQMENMMFDEQPGRLHS
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: NHAP2_SHEPC
Sequence: MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYSTAYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVDTELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSNKLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDILLPGFALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVYCLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDALSHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHPVIGDHFQWQSLHWVVAGLHEGKVTNIGIRLPPET
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MMF1_PSEA3
Sequence: MDDKIALTSNDGERPRMKKDWRFWTIFAALMLIAFLAALDMTMISTALPAIVAALPPSSIAANWITSAFLLPMVASQPIFGGLSCSLGRKNSVISALVIFLVGSIVCATAKSVLVLVVGRGVQGLGGGGIHALSEIIMSDLTTLRERGVYFGLIALVFAVAGFIAPVLGGVFSHSSWPWIFWINLPIGAVALVLLVLFLNIRVPLLTGRQKWEKLDLVGNAILFGSVTAVLIAVTEGGIKYRWSDARVWVPLVVGLIGLVAFLMVEWIPGPLCRQPVFPRDLFANRTAAVAYLQTFLHGVIFYGIIYMVPIYFQAIKDRTPLQSAIWSFPLTAPSTPLALIAGLLISISGRYKKLIFIGWALMAGGVGWLTHWSVGTSKAEWAISQIIAGAGIGIMFPITLPPIQASLPVERLEAATAAYAFSRTFGAVWGITGATTIFATQAAKKLRPDYGQLEPLGLNDFTVIAFAESLRYLPEQLQVLVKKVYADAISDSFWLFVPLAIIGFASTFLLKDLPLPDFIKSQAVLEEKGASENASPPESLA
What is the function of this protein?
Glycosyltransferase; part of the gene cluster that mediates the biosynthesis of mannosylerythritol lipids (MELs), surface-active substances that enhance the availability of water-insoluble substrates (Probable) (PubMed:31923270).  MMF1 is directly involved in the secretiopn of MALs (Probable).
What are the official names of this protein?
MFS-type efflux pump MMF1, Mannosylerythritol lipids (MELs) biosynthesis cluster protein MMF1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1119_STAAW
Sequence: MGQNDLVKTLRMNYLFDFYQSLLTNKQRNYLELFYLEDYSLSEIADTFNVSRQAVYDNIRRTGDLVEDYEKKLELYQKFEQRREIYDEMKQHLSNPEQIQRYIQQLEDLE
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein MW1119.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: FSP4_VULVU
Sequence: XXYQTDELARVLSPT
What are the official names of this protein?
Autoantigenic sperm protein 4, fSP4.
Protein: MOAA_CLOAB
Sequence: MIDKHGRNIDYLRISVTDRCNLRCIYCMPKMKGYIQENNKISCSDIFKLLRAAVSVGINKVRYTGGEPLLNEEISKIIYETSKLPQINDIAITTNGILLPQMAKDLKKAGLKRVNISLDTLKSDTFTKITNFNQITKVIDGIDTCLKLNLKPVKINTVLIKGINDLEVNDFVNLSREMPVEIRFIELMPIGEGAKIYEKGRVNIKELLMSRSDLIPIESLQNSTANMYKIKGGKGRIGYITPISCKFCSTCNKIRLTSMGTIKPCLHSNQEIDLKPYLNNEDVLVEKLKTIIFNKTFQHHINEENISRSKKMMYQIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: IF2_XANOM
Sequence: MSQQTTIRKLAELVNTPVDKLLVQLAEAGMKFSGPDQVVTSTEKMKLLGFLRRTHGKAETPAEAASEAAKKITLNRRKLQEVTVSAGRTKTTVNVEVRQKRTYVKSENEGSGRATPMTPDEERADILAKLAASRQRNLDEQQRLAESDRVRDEEIQRKRDEEQAAKDRAEAERKAAEEAAAAASAPAPAPVAAAPTPSAAAPAARAPSSPSSAPRPSRPGGASPASRPSTPARPDDRNNAAKHKTRGSHVMVAGVEDDDATKRFAGQLHLSAADRARRSNVRGKPTGRPGSSSSRRGNDNGRGSNQANSGPHGFERPTAPVVREVAIGETITVADLAQKLALKGGDVVKALFKMGVMATITQSIDHDTAALVTEELGHKAVRADNADFEDALLAHAEDAQGDTTTRPPVVTIMGHVDHGKTSLLDYIRRTKIASGEAGGITQHIGAYHVETDRGVISFLDTPGHAAFTSMRARGAKITDIVVLVVAADDGVMPQTKEAVAHAKAAGVPLIVAVNKIDKAGADPLRVKNELLAENVVAEDFGGDTQFIEVSAKVGTGVDTLLDAISLQAEVLELKAVAEGRASGTVIESSLDKGRGPVATVLVQQGALKRGDYLVCGIQYGRVRALFDETGHQPGSAGPSIPVQVLGLSGVPEAGDDFVVVDDERLAKDVAQQRETKRRESRLVASATNRMEDILAQMGKGEGQQVLNLVIKADVQGSVEALKQSLVALSNEDIRINVIHSGVGGITESDANSAAASKATIIGFNVRADASARKIVESNGVDLRYFSIIYDVIDQVKQVASGLLGVEIREEIMGIAQVRDVFRSSKFGAVAGCMIIEGVVKRSKPIRVLRDSVVVFEGELESLRRFKENVDEVRNGNECGIGVKAYNDVKAGDQIECFERIEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP2B1_DROME
Sequence: MSATSTRSSVTRKSSLSKSSSSDKSAKSSSNSSKSPTAASGNKQKMQYTKTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVTRSSSSSSNNNNNNSNTSSTTTTKDISNTSSNDTATVTKTSRTTVKSATTSNVRAGFTAKKFP
What is the function of this protein?
Calcium-dependent, calmodulin-stimulated protein phosphatase.  This subunit may have a role in the calmodulin activation of calcineurin.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2B catalytic subunit 1, Calmodulin-dependent calcineurin A1 subunit.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2B subfamily.
Protein: HLGA_STAAU
Sequence: MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity.
What are the official names of this protein?
Gamma-hemolysin component A, H-gamma-2, H-gamma-II.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FETP_THISH
Sequence: MARMVNCVLLGKEAEGLDFPPYPGELGKKIYEGVSKEAWQKWVKHQTMLINEYRLTPVDPKARKFLEEEMDKFFFSGGSTKPEGYVAPSK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: EFTS_NITOC
Sequence: MAITAAQVKELRERTGSGMMECKKALVETGGDIETAIEWMRKQGLAKADKKAGRVAAEGIIVTAVSQDGRKAAMVEVNSETDFVAKNEDFRQFAEDVAHQALISNPATLEDLTSLPLGKGRESVDERRHALVAKIGENLNVRRFTLVEAENGCIGRYVHGDRIGVLVAVEGGEEALAKDLAMHIAASKPQAIAPKDIPVEILDKERAIQIAQAKDSGKPPEIIEKMVQGRLQKFLSEITLLGQPFVKDPDIKVEKLLKDAGANVYRFARFEVGEGIEKKVENFAEEVRSQAQGD
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUX1_HYPJE
Sequence: MYRKLAVISAFLATARAQSACTLQSETHPPLTWQKCSSGGTCTQQTGSVVIDANWRWTHATNSSTNCYDGNTWSSTLCPDNETCAKNCCLDGAAYASTYGVTTSGNSLSIGFVTQSAQKNVGARLYLMASDTTYQEFTLLGNEFSFDVDVSQLPCGLNGALYFVSMDADGGVSKYPTNTAGAKYGTGYCDSQCPRDLKFINGQANVEGWEPSSNNANTGIGGHGSCCSEMDIWEANSISEALTPHPCTTVGQEICEGDGCGGTYSDNRYGGTCDPDGCDWNPYRLGNTSFYGPGSSFTLDTTKKLTVVTQFETSGAINRYYVQNGVTFQQPNAELGSYSGNELNDDYCTAEEAEFGGSSFSDKGGLTQFKKATSGGMVLVMSLWDDYYANMLWLDSTYPTNETSSTPGAVRGSCSTSSGVPAQVESQSPNAKVTFSNIKFGPIGSTGNPSGGNPPGGNRGTTTTRRPATTTGSSPGPTQSHYGQCGGIGYSGPTVCASGTTCQVLNPYYSQCL
What is the function of this protein?
Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose (Ref. 4).  The degradation of cellulose involves an interplay between different cellulolytic enzymes.  Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs).  The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain.  Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase, Cellobiohydrolase 7A, Cel7A, Exocellobiohydrolase I, CBHI, Exoglucanase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TBB2A_MACFA
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2A chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FOLD_YERPB
Sequence: MSAKIIDGKTIAQQVRNEVAAVVQQRLAAGKRAPGLAVVLVGENPASQIYVASKRKACEEVGFVSRSYDLPMATSEAELLALIDSLNEDTEIDGILIQLPLPNGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPKLRACTPRGIMTLLERYDIPTYGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLESGKVVGDVAFDVAAERAGWITPVPGGVGPMTVATLIQNTLQACEEYHDISQN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CXA6_RAT
Sequence: MSDWSALHQLLEKVQPYSTAGGKVWIKVLFIFRILLLGTAIESAWSDEQFEFHCNTQQPGCENVCYDQAFPISHVRLWVLQVIFVSVPTLLHLAHVYYVIRQNEKLKKQEEEELKVAHFNGASGERRLQKHTGKHIKCGSKEHGNRKMRGRLLLTYMASIFFKSVFEVAFLLIQWYLYGFTLSAVYICEQSPCPHRVDCFLSRPTEKTIFILFMLVVSMVSFVLNVIELFYVLFKAIKNHLGNEKEEVYCNPVELQKPSCVSSSAVLTTICSSDQVVPVGLSSFYM
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction alpha-6 protein, Connexin-33, Cx33.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: MHPB_XANP2
Sequence: MTIKLKCLSHTPLRGLNDPAPEVIAEVDAVLARARADVEAFDPELIVIFAPDHYNGLFYDLMPPFVIATAAKSVGDYMTLPGPLSVERDLALELARFILDHDVDISLSHRLQVDHGCTQTLEELTGSLTRYPVIPIIINSVAPPFAPYRRIRRLGEVVGQFIATLDKRVLVLGTGGLSHEPPVPLLEGAPEAIGEFLICGRNPTPEARAARQERTIAAGKIYGTELSAQTPLNAEWDQAFIDLLLDARLDAVDDFSIEEISKEAGRSTHEVRTWVAAFAALAAARGGYSAHRDYYRPINEWIAGYGVMSAEPR
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.