Protein: HERC2_DROME
Sequence: MFNRQASGGAGSSGQGAGSSQTASAAPVSAGVGVGGGGGASGAAAGAGSAAGSGSGSGSGSAAPPSHSPDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCRFQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTHFSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSEDNSDLESVASHEG
What is the function of this protein?
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase HERC2, HECT domain and RCC1-like domain-containing protein 2, HECT-type E3 ubiquitin transferase HERC2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.