PharMolix/UniProtQA huggingface dataset:
Protein: HMDH_RABIT
Sequence: MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDSCCRREPVVVRNNQKFCSVEEEAGMSQDRKVEVIKPLVAETDSPHRAAFVVGGSSFPDTSLVLETKEPEIELPKEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVLGACCENVIGYMPIPVGVVGPLCLDGKEFQVPMATTEGCLVASTNRGCRAICLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLHISMAGRNLYIRFQSRTGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANYVTAIYIACGQDAAQNVGSSNCITLMEASGPPNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDSPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLEGACTKKAA
What is the function of this protein?
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: SIX3_HUMAN
Sequence: MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV
What is the function of this protein?
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes.  During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon.  Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression.  In addition, Six3 activity is required for the formation of the telencephalon.  During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration.  Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2.  During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm.  In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation.  Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory.  Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner.  Furthermore, during eye development regulates several genes expression.  Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element.  Directly activates RHO transcription, or cooperates with CRX or NRL.  Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures.  During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity).  Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.
What are the official names of this protein?
Homeobox protein SIX3, Sine oculis homeobox homolog 3.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUXX_THEVO
Sequence: MPKTVANTKPMDVLKNALSRNVLIDVKGNREYSGILEGYDVYMNVVLQNASEIINGENKGVFDRILVRGDNVIFVSPSKGDNE
What are the official names of this protein?
Putative snRNP Sm-like protein.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
Protein: MOAC_SALNS
Sequence: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIVDGKHHKGDVFATARIAGIQAAKRTWELIPLCHPLLLSKVEIQLQAEPEHNRVRIESLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVDAHD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: GSTM2_PONAB
Sequence: MPIILGYWNIRGLAHSIRLLLEYTDSSYEEKKYMMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGETEKEKIQEDILENQLMDNRMQLARLCYNPDFEKLKPEYLEGLPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Participates in the formation of novel hepoxilin regioisomers.
What are the official names of this protein?
Glutathione S-transferase Mu 2, GST class-mu 2, GSTM2-2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Mu family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_ECO7I
Sequence: MAKNYYDITLALAGICQSARLVQQLAHQGHCDGDALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL
What is the function of this protein?
Negative regulator of phage lambda lysogenization.  Contributes to the degradation of the phage regulatory protein CII.  Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease.
What are the official names of this protein?
High frequency lysogenization protein HflD.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ENDR_PAEPO
Sequence: MVTTMKEVAERAGVSKSTVSQFLQKRYNYMSENTKKKIEQAIEDLSYIPNEVARSLKQKKTFIVGVISSTILSRFTTEVVRAIEDECQLENVQVIVCNTDDDSLKEKKYVQSMIARQVDGLIIFPTEENKKLYVSLVKNGYPFVFVDRKIDELSVDTVLLNNEKASRACVEALIEHGHNNIGIITFPLGKKAITTRSERLSGYRNTLGKHDIPVNENYIKSGRLDEMPNLIGQLFHMENPPTAIIATNDMILEQVLIYAKNNHLTIPNDFSLIGIDDVSFASFYNPPITTVSQPSFEMGKRSARLLLEKIDQKEQDHEELSEIIRMNPVINHRESVLKLN
What is the function of this protein?
Putative repressor of the endoglucanase operon.
What are the official names of this protein?
Probable HTH-type transcriptional regulator EndR.
Protein: LFTR_CHLL3
Sequence: MIPVDALLKAYREGFFPMADASDGQLYWCRPEMRALFPLESYRPSRDVLRLQRRGEYSVFFDSDFEAVIRACAAPRKDDPETWISGEIVETYIRIHELGLAHSVECRYRGELAGGLYGIAIGGAFFGESMFYRRSYASQVALWHLVCHLRLKGYLMLDAQIMNPHLRRLGAVEVPHDEYMRLLEAALRKKTAFL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARB_LISMC
Sequence: MPKRDDIKTILVIGSGPIVIGQAAEFDYAGTQACLSLKEEGYRVVLVNSNPATIMTDAEMADKVYIEPITLDFVSRIIRKERPDAILPTLGGQTGLNMAMELSAAGILDECNVEVLGTDLTAIKKAEDREAFRDLMNELGEPVPESDIIHNLDEAYTFVERIGYPVIVRPAYTLGGSGGGICHNEQELIETVTSGLKLSPVTQCLLEKSIAGFKEVEYEVMRDANNNAMVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRDVSLKIIRALEIEGGCNVQLALDPDSYNYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVRNPVTGTTFAHFEPTLDYVVAKIPRFAFDKFEQADRRLGTQMKATGEVMAIGRSWEEALLKAVRSLEIGADHLLLEEAENADEATLERKICFPEDDRLFFLAAALRRGQTIEQLHAKTKIDLFFLYKLSKTIELENRIKENPQNQEILAEAKRAGFSDAFLATCWNVDEQAIYDLRKAQNLFPVYKMVDTCAAEFESTTPYFYSTYEEENESTRSAKESVIVLGSGPIRIGQGVEFDYATVHSVWAIQQAGYEAIIINNNPETVSTDFSISDKLYFEPLTLEDVMHVIEIEQPLGVVVQFGGQTAINLADGLAKRGVKILGTSLEDTDRAENRDAFEKALGILQIPQPAGKTATSVEEAINVATDIGYPVLVRPSYVLGGRAMEIVESEEALKHYMTNAVKVNPKHPVLVDRYVSGQEVEVDAISDGENVLIPGIMEHIERAGVHSGDSIAVYPAQRLSSQVKNTIVDYTTRLATGLNIIGMLNIQYVVDGEEVFVIEVNPRSSRTAPFLSKITEIPMANVATRVILGENLIDLGYTPGLAPEKQEIFVKVPVFSFAKLRSVDTSLGPEMKSTGEVMGKDVTLEKALYKGFVASGTTMHDYGTVLLTVADRDKEEAVELAKRFNRIGFTIMATKGTASTLEEADIPVSQVKKIGENQETLIDYIRNGQVTLVVNTLTTGKRPERDGFQIRRESVENGIPVCTSLDTAEAILRVLESRSFELESMNTSEVKQPKARV
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: NUOI2_ANADE
Sequence: MPQTVRAYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLEVDSGICTGCQACERACPIGCIQISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTGSIQHTREFEGTHKHIRNLVFRWADPMNPFPVYKVDKNAEYYPRVPLGSLVRQRLETMAWDRSAPQFLPPEPPKPAEAKPAAKAAPAAKPAAAAPAAPAAAAPAAAPAPAKPAAAPAPAAAAAPAAPAAEAPAAPAAPAANPESK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 2, NADH dehydrogenase I subunit I 2, NDH-1 subunit I 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y2345_MYCTU
Sequence: MRLVRLLGMVLTILAAGLLLGPPAGAQPPFRLSNYVTDNAGVLTSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELGNYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSGAAVAAANGLNRSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRRRRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNELALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRRELLTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRIGPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQAVSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADIQTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRARGAADPLTAFDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYIDTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHAQSLANADVQSAQRAYTRRGGNNAGAILGGIIIGDLLSGGTRGGLGGWIPTSFGGSSNAPGSSPDGGFLGGGGRF
What is the function of this protein?
May play a role in septum formation.
What are the official names of this protein?
UPF0603 protein Rv2345.
What is the protein family that this protein belongs to?
Belongs to the UPF0603 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSB28_PROMS
Sequence: MTSNKTAKIQFYEGTDEPVVPEIRLTRSKDGTTGQALFLFEKPQALSSITDGEITGMRMIDTEGEILTREVKVKFVDGEPIFLEAVYIWKNTPDFDRFMRFANSYAKSNGLGYSEKK
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PROA_SHEWM
Sequence: MIENNELYLQTLGQNAKQASYGLASLTGTQKKALLSAIAASLTAKSQAILAANQKDVAAARENGLSEAMIDRLLLDDARLKGVISDIDNVISLNDPVGTELESQLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLNSNMALSEAIREAITEQGLAADSVQLIKSPDRTLVSGLLKLDQFVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHLYMDKDANIAKSIEVIANAKVQRPTVCNALDTVLIHDSLAETALPQLFSNLSAQGVSFYGCEQTKAIADKLGLAISTATDETYGQEWLSLTLGIKVVADIDTAIGHIRRYSSGHSEGILTDNIHASAHFINQVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGLGEYTVRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_ECOL5
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMHVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S38A9_DANRE
Sequence: MDEDSKPLLGSVPTGDYYTDSLDPKQRRPFHVEPRNIVGEDVQERVSAEAAVLSSRVHYYSRLTGSSDRLLAPPDHVIPSHEDIYIYSPLGTAFKVQGGDSPIKNPSIVTIFAIWNTMMGTSILSIPWGIKQAGFTLGIIIIVLMGLLTLYCCYRVLKSTKSIPYVDTSDWEFPDVCKYYFGGFGKWSSLVFSLVSLIGAMVVYWVLMSNFLFNTGKFIFNYVHNVNTSDAFGTNGTERVICPYPDVDPHGNSSTSLYSGSDNSTGLEFDHWWSKTNTIPFYLILLLLPLLNFRSASFFARFTFLGTISVIYLIFLVTYKAIQLGFHLEFHWFDSSMFFVPEFRTLFPQLSGVLTLAFFIHNCIITLMKNNKHQENNVRDLSLAYLLVGLTYLYVGVLIFAAFPSPPLSKECIEPNFLDNFPSSDILVFVARTFLLFQMTTVYPLLGYLVRVQLMGQIFGNHYPGFLHVFVLNVFVVGAGVLMARFYPNIGSIIRYSGALCGLALVFVLPSLIHMVSLKRRGELRWTSTLFHGFLILLGVANLLGQFFM
What is the function of this protein?
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels.  Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (By similarity).  Acts as an arginine sensor (PubMed:33296665).  Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:33296665).  However, the transport mechanism is not well defined and the role of sodium is not clear.  Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency (By similarity).
What are the official names of this protein?
Neutral amino acid transporter 9, Solute carrier family 38 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Protein: TGT_SALPC
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPAFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRDRFDSLGNKNALFGIIQGSVYEDLRDISVKGLVEIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKSDTSPLDAECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTKFYQRQGRPVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: EI2BL_PYRHO
Sequence: MLPERVLEILREMKRERIKGASWLAKKGAEAFLTLAEELDESLLEDAIMELREEVVKVNPSMASLYNLARFIPVTNRRDILKSRALEFLRRMEEAKRELASIGAQLIDDGDVIITHSFSSTVLEIIRTAKERKKRFKVILTESSPDYEGLHLARELEFSGIEFEVITDAQMGLFCREASIAIVGADMITKDGYVVNKAGTYLLALACHENAIPFYVAAETYKFHPTLKSGDVMLMERDLIRGNVRIRNVLFDVTPWKYVRGIITELGIVIPPRDIQ
What is the function of this protein?
Catalyzes the exchange of initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Putative translation initiation factor eIF-2B subunit 2-like, eIF-2B GDP-GTP exchange factor.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: REV_SIVG1
Sequence: MSLGKEEKQALKIIKTLYGSNPYPQFSGTARQRRRARQRWRKQQQQIDKIAGRVLNTFEDQQLVAQLQELQLENKDLVLQHLPDPPHIHQDSSGIPAVWAPATPRGSNRACSSSGEGCEGSLGQTGCYCPIRLSGSHQQSKKSAARP
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: RRF_YERPS
Sequence: MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVEDSRTLALTVFDRSLSAAVEKAIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAEAEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKKVDAALAVKEAELMDF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERN2_MEDTR
Sequence: MEIQFDEPKKSLRPKKVNKFKGRNKKSETRDKFVGVRQRPSGRYVAEIKDTTQNIRMWLGTFETAEEAARAYDEAATLLRGSKTRTNFVTHVSYDSPLASRIRHLLNNRKKGTKQQDMNGISSTTSHADTTNDTTSDGSTSSTTNCIGTASGAINSTSASGVTSTSTNISTSASGVASTSTDISTNSSNTNVNDKSESLLSSSTTMQKPNLFEDAYRPDMSNLTNEYESSSYKSNVSWDFGPIFDNFPFDQWLDMTNNDGLLCDMVDKGVSEFERMKVERQISASLYAINGVQEYMKNVQDCNEAQWNLSPLC
What is the function of this protein?
Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs).  Binds to the GCC box (NF-responsive box) of ENOD11 promoter.  Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349).  Involved in early stages of root nodule development.  Functions redundantly with ERN1.  Is essential with ERN1 for the initiation of root hair infection, and nodule organogenesis and development.  Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242).
What are the official names of this protein?
Ethylene-responsive transcription factor ERN2, ERF transcription factor ERN2, NF box-binding protein 2, Protein ERF REQUIRED FOR NODULATION 2.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIE_CORJK
Sequence: MSASLDLRCYLVTGAPHEKVVDVAAAAAAGGAGVVQVRSKPISVRDLTALAVEVAAAVQKANPATRVLIDDRVDVAAALMPEHNIHGVHIGQDDLDPRLARQLLGKDAIIGLTTGTLPLVQQANEYADVIDYIGAGPFRPTPTKDSGREPLGLEGYPALVEASRVPVVAIGDVHAEDAADLAATGVAGLAIVRGIMQAENPKAYAESVVSQFSEANER
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL22_CLYEP
Sequence: MNVKAIANQXSVAPRKTRLVADLIRGKHVREAQAILMFTPKAASPIVSKLLKSAVANAVHNFSLKEEELYVKEIFVNEGLRLTRLLPRAKG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SFRP4_HUMAN
Sequence: MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types (By similarity).  SFRP4 plays a role in bone morphogenesis.  May also act as a regulator of adult uterine morphology and function.  May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity).  Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
What are the official names of this protein?
Secreted frizzled-related protein 4, sFRP-4, Frizzled protein, human endometrium, FrpHE.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted. Note=Cytoplasmic in ovarian tumor cells.
Protein: Y2578_JANMA
Sequence: MDARLLDILVCPICKGPLEHDKKAQELICKADKLAYPIRDGIPIMWADQARDLQVTPGTN
What are the official names of this protein?
UPF0434 protein mma_2578.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.