PharMolix/UniProtQA huggingface dataset:
Protein: RHO_BUCAP
Sequence: MNLTALKNMPVSELITLGEKMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNAVNYDKPENARSKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTILLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALVDTGSKMDEVIYEEFKGTGNMELPLSRKIAEKRVFPAIDYNRSGTRKEELLTLPDELQKMWILRKIIHPMSEIDAMEFLLNKLSMTKTNDEFFDMMKRS
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: AMIA2_MYCBO
Sequence: MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSLRAIDVSQPTLNAFRVVLTESALADAAAADKRRAAGDTAPLLGIPIAVKDDVDVAGVPTAFGTQGYVAPATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPEAFNGVTVNGVLARTVEDAALVLDAASGNVEGDRHQPPPVTVSDFVGIAPGPLKIALSTHFPYTGFRAKLHPEILAATQRVGDQLELLGHTVVKGNPDYGLRLSWNFLARSTAGLWEWAERLGDEVTLDRRTVSNLRMGHVLSQAILRSARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPMARAFDRLGSFGTDRAIIAACPSTWPWNLLGWPSINVPAGFTSDGLPIGVQLMGPANSEGMLISLAAELEAVSGWATKQPQVWWTS
What are the official names of this protein?
Putative amidase AmiA2.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
Protein: VG61_ICHVA
Sequence: MISVARAMTDSDSLVVSTVDRNSDMKFIWPEKVYFRGCTHRSIPLLDDAAFNERMLCQDDLTLLKFGLDFFMRSTPFLKSFWLTEFGLVMVTDALTEYAMRIWRAINRVHLGDTDAPTVAEITRHINHLSGRTMMIPSIYSGPKNGQYPILNKMHELFTLFATGKISILNHEILPEAALLHEQTHDLLDRLTRDLPLFLEYEDGPRSDPFTHVDRLGKLRARGEVVMYACVEPTPVPRSVDLWEHMSEMYAESCYWLLQRETPRNMIALMDFIHVKTGYSTTTNELMGYMRDRTSTIDILAFLFELTAGDFTWNFWALV
What are the official names of this protein?
Uncharacterized protein ORF61.
Protein: CHO2_YEAST
Sequence: MSSCKTTLSEMVGSVTKDRGTINVEARTRSSNVTFKPPVTHDMVRSLFDPTLKKSLLEKCIALAIISNFFICYWVFQRFGLQFTKYFFLVQYLFWRIAYNLGIGLVLHYQSHYETLTNCAKTHAIFSKIPQNKDANSNFSTNSNSFSEKFWNFIRKFCQYEIRSKMPKEYDLFAYPEEINVWLIFRQFVDLILMQDFVTYIIYVYLSIPYSWVQIFNWRSLLGVILILFNIWVKLDAHRVVKDYAWYWGDFFFLEESELIFDGVFNISPHPMYSIGYLGYYGLSLICNDYKVLLVSVFGHYSQFLFLKYVENPHIERTYGDGTDSDSQMNSRIDDLISKENYDYSRPLINMGLSFNNFNKLRFTDYFTIGTVAALMLGTIMNARFINLNYLFITVFVTKLVSWLFISTILYKQSQSKWFTRLFLENGYTQVYSYEQWQFIYNYYLVLTYTLMIIHTGLQIWSNFSNINNSQLIFGLILVALQTWCDKETRLAISDFGWFYGDFFLSNYISTRKLTSQGIYRYLNHPEAVLGVVGVWGTVLMTNFAVTNIILAVLWTLTNFILVKFIETPHVNKIYGKTKRVSGVGKTLLGLKPLRQVSDIVNRIENIIIKSLVDESKNSNGGAELLPKNYQDNKEWNILIQEAMDSVATRLSPYCELKIENEQVETNFVLPTPVTLNWKMPIELYNGDDWIGLYKVIDTRADREKTRVGSGGHWSATSKDSYMNHGLRHKESVTEIKATEKYVQGKVTFDTSLLYFENGIYEFRYHSGNSHKVLLISTPFEISLPVLNTTTPELFEKDLTEFLTKVNVLKDGKFRPLGNKFFGMDSLKQLIKNSIGVELSSEYMRRVNGDAHVISHRAWDIKQTLDSLA
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).  Preferentially converts di-C16:1 substrates.
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT, Choline-requiring protein 2.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi- pass membrane protein.
Protein: BDNF_ACRJA
Sequence: SCMKAAPMKEISIRGQGSLAYPGLQTQGNLDTLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQPSKENKDADLYSSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSTKGYAKEGCRGIDKRYWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: VGF_VACCA
Sequence: MLINYLMLLFAAMIIRSFADSGNAIETTSPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIMLVLVGIIIITCCLLSVYRFTRRTKLPIQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.  This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells.  Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival.  The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo (By similarity).
What are the official names of this protein?
Pro-vaccinia growth factor, Pro-VGF.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
What are the subcellular locations of this protein?
[Pro-vaccinia growth factor]: Host membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Vaccinia growth factor]: Secreted.
Protein: KRA61_HUMAN
Sequence: MCGSYYGNYYGTPGYGFCGYGGLGYGYGGLGCGYGSCCGCGFRRLGCGYGYGSRSLCGYGYGCGSGSGYYY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 6-1.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 6 family.
Protein: PANB_EDWI9
Sequence: MTPTTLSHLRKRKQEKHKFATITAYDASFARLFAEQGIDVMLVGDSLGMTLQGHDTTLSVTVADIAYHTRAVRAGAPACLLMADMPFMSYATPELACTNAAELMRAGANLVKMEGGAWLCDSVRMLTERAVPVCGHLGLMPQSVNIFGGYRVQGRDQDAADQLLSDALALEGAGAQMLVLECVPAQVAKTISEALRIPVIGIGAGRDTDGQILVMHDALGISSGHMPSFVKNFLAAEGDIRAAVRRYINDVEQGLFPADEHTFN
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_DESHY
Sequence: MAKKVVGLVKLAINAGKANPAPPVGPALGQHGVNIMAFCKEYNERTKDQAGLIIPVEITVYEDRSFTFITKTPPASILLKKAANINSGSSEPNRKKVAQVSKTKVREIAETKMKDLNAASVEAAMSMVEGTARSMGITIVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SPDYA_HUMAN
Sequence: MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE
What is the function of this protein?
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555).  Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995).  Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).
What are the official names of this protein?
Speedy protein A, Rapid inducer of G2/M progression in oocytes A, RINGO A, hSpy/Ringo A, Speedy-1, Spy1.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CTAA_PARDP
Sequence: MARRPVFQEVTETTPPGTTPSGGMIDAGHKGARGAIRLWLVVLFVMVAAMIALGGATRLTGSGLSITEWKPVTGAIPPMDAATWQAEFDKYRQIPQFELVNSDMDLASFKRIYWWEWSHRLLGRLVGLVWAAGFVFFLATRRIPTGWTPRLLLLGALGGAQGAIGWWMVHSGLSGEMVRVASYRLATHLGLAFAILGLIAWYVLALSRSEAALLRARRAGEAKLFSMTTGLMHLAFVQILLGALVAGIDAGRMYTGWPTMGGEWIPAEIWDATLGWRNFFENPALVQFIHRMTGYLLAVFAVVVFLRARRSPHPVTRGAYVAMLVALAVQVALGIMNVLHASPLPLALAHQIGAVALFTLILRARHHARYPYETSVRGTVR
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSP11_OXYRB
Sequence: MSLIPNNWFNTGRRSNIFDPFSLDEIWDPFFGLPSTLSTVPRSETAAETAAFANARIDWKETPEAHVFKADLPGVKKEEVKVEVEDGNVLRISGQRAREKEEKNDTWHRVERSSGQFMRKFRLPENAKVDQVKAGMENGVLTVTVPKNEAPKPQVKAINVY
What are the official names of this protein?
18.3 kDa class I heat shock protein, HSP 18.3.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_EDWI9
Sequence: MSSILFNRRWASVLLEALTRHGVHHVCIAPGSRSTPLTMAAASHPRLHSHTHFDERGLGHLALGLAKVSGQPVAVIVTSGTAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAIRQQNMFASHPTETLSLPRPTPDISAAWLVSSIDSAMARLDHGALHINCPFADPLYGEDDDGQQGWSAALGCWWQGETPWLQESSPYTGALRAEVDWAQWRRRRGVVLIGRVDAEAGRQAAAWGEELGWPVLGDVLSQSGQPLPCADLWLPHAEARRLLAQAEIVVQFGASLTGKRLLQWQAACKPQRYWLIDPLPGRLDPACHRGRRLVAPVQAWLQAHPAQPAAPWAPQLKVLAGRAAQCVEQTLQASFGEAQVAHRLAQLLPLRGQLFVGNSLIVRLVDALGQLPAGYPVYSNRGASGIDGLVSTIAGVQRGSGLPTLAILGDLSALYDINGLALLRQVTAPTVVIVVNNNGGQIFSMLPTPPAERERFYLMPQNVDFRHAAALFDLDYACPVDWAALTDAVSQGWRRCGTTLIELRVPGTAGAEALQQLLGKVAAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: FLAC_METVO
Sequence: MPNISEIIDDIKQKIKLGKKNDTTPLEDDSEDEFSFVLDEETTAESDNDLVAANEELLAKMGELESKFPKIEMMVTNLRKENENLRSDIHNINENFQDMMALYEVVSNQINPFIGISKVTATSMEKVEKIEHESTNLKKRVEELQNDVVILANVYLQEHDIDLDGVINEILAEEEFSKAILGEDSDDW
What are the official names of this protein?
Putative flagella-related protein C.
What is the protein family that this protein belongs to?
To M.jannaschii FlaC.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: RS1_SYNP6
Sequence: MVTQDIPAVDIGFTHEDFAALLDQYDYHFNPGDTVVGTVFNLEPRGALIDIGAKTAAFLPVQEMSINRVESPEEVLQPSEMREFFILSDENEDGQLTLSIRRIEYMRAWERVRQLQTEDATVRSEVFATNRGGALVRIEGLRGFIPGSHISTRKAKEDLVGEELPLKFLEVDEDRNRLVLSHRRALVERKMNRLEVGEVVVGAVRGIKPYGAFIDIGGVSGLLHISEISHDHIETPHSVFNVNDEVKVMIIDLDAERGRISLSTKQLEPEPGDMVRNPEVVYEKAEEMAAQYREKLKQQAEGLVVTE
What is the function of this protein?
Binds mRNA.
What are the official names of this protein?
30S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
Protein: CDPAS_METM7
Sequence: MDLLLLLFSAIWYILPAYVANAVPCILGGGRPVDLGKNFFDGNRIIGNGVTYRGTFFGILFGIITGILQHFIVILYMDPQSVFNYGLTGYIILGFLLGTGALFGDMLGSFIKRRLKLNQGQSAPLLDQMTFIVFALIFAYPLYQQPVNLMVILLVISPIIHFSSNIIAYKLHLKKVWW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WSB2_BOVIN
Sequence: MLSPAPEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSKKLWARHHPQVPDVSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQLNPPMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
WD repeat and SOCS box-containing protein 2, WSB-2.
Protein: RL2_XANCB
Sequence: MPLMKFKPTSPGRRSAVRVVTPDLHKGAPHAALLDSQSKSGGRNHHGRITVRHVGGGHKQHYRIIDFKRNKEGIPARVERIEYDPNRTAHIALLCYVDGERRYIIAPKGLKAGDQVIAGANAPIKTGNALPLRNIPVGTTVHGIELKPGKGAQIARAAGAAVQLVAREGIYATLRLRSGEMRKVPVECRATIGEVGNDEHNLEKLGKAGAKRRRGVRPTVRGAAMNANDHPHGGGEAKAGQGNPHPVTPWGVPTKGYKTRKNKRTQQFIVRDRRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PYRC_SHIBS
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVMPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHNFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREAHFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: PSAM_ZYGCR
Sequence: MTIISDSQIVVALISALVTGILALRLGRELYR
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HEAT6_XENLA
Sequence: MAAQEDRLDSFGMQHGILLSSSPSLQPPYNHQEYAWDFQRYLNKLQSLRPSDSESFRTEINLLLDQLISQDYTPGVTGIGQEEVCAILVQACRLVQHNQEHLVSKVCQLVHYLLNRLQVIVDEQNLDFLLAFSISALKQCSSWTHADVLHALAALVYNNGSKCQKYLNELLGPTGILVNLCDPSQPDPELWREAIHCMANLCLGVPGHPYLDEPYRMTCFKNFLTVLQTPKPNIVDDIAVCTLLQNALKGIQSLLNGSKIKLLETGQLGSLLAVLKKYMFHGLPGLSIEMPTVLYPTPLAQYDGRSPTKPEQPEAAVNQPTWSKKKRKAGKQKKGHQGEESKEELKNEIGAEINKDLEKMKLCSGEAQHSLYLGPQKSPLDPHQGQVGKDHFSPQVQRYKKINSSDSEYSDAEGSLQNKIRSFQAKVRQGALSCFLSTIKSIEKKVLYGYWSAFVPDISGIGSPQSVSLMTIALKDSSPKTRACALQVLSAILDGSKQFLSVADDASDHKRAFTPLSVTLASSIRELHRCLLLAIVAESSAQTLTQIIKCLANLVSNAPYHRLKPGLLTRVWNQIKPYIRNKDVNVRVSSLTLLGAIVSAQVSLPEVQLLLQQPLYSLSQNSGSATPSDPESNRKESMLEGGKKNGLHSEHSQSCWLIRLCITLVVEPREDSYSDSEPSSTPAVMYEPSPVRLEALQVLACLVKGCFNMAQSYLIELGEVACKCMQETDASIQLHGAKLLEELGTGIVQQQKPDSIVPINLMVPINQAVTFWNMILNGPLPAALQNEQHPTLQTSACDALSSVLPEAFSNLPNDRQILCITLLLGLNHSENPLVKAAAARALGVYILFPCLRQDVMFVADTANAILMCLSDRSPNVRAKAAWSLGNLTDSLIVNMEAMGQSFQEEFSDMLLLKMLWAATEASKDKDKVKSNAVRALGNLLHFLQPYHIVKPRFCESIECAIQALVSTVLGDGTMKVKWNACYALGNVFKNTALPLGKATWTAAAYNALTTVVKACKNFKVRIKSAMALSIPFSREQYGSTEQYCDIWNALVTALQKSEDTEDFLEFKYSASLREQICQALIHLLSLASQEDLPRIRKTLLEKGDSIRNYVLHYVKSEVQGDESQREHQDRGKMLQRAIEHIRGFEELPGSNKGLIEVAYFEAILVSCDKEMEAL
What are the official names of this protein?
HEAT repeat-containing protein 6.
Protein: GLYA_DESAP
Sequence: MVWNRSLAETDPEIARAIALEITRQGAKLELIASENFVSRAVLEAQGSVLTNKYAEGYPGARYYGGCEYVDIVESVAIRRAKEIFGAGHANVQPHSGAQANMAAYFAFLEPGDTIMGMRLAHGGHLTHGAKINFSGRYFRYVPYGVEEETGRIDYDRMHAIAREHRPKLIVGGASAYPRELDFARMRAIADDVGALLMIDMAHIAGLIAAGLHMSPVPYADVVTTTTHKTLRGPRGGMILCPEEYAAAIDKAVFPGIQGGPLMHVIAAKAVALGEAQRPEFKTYQEQIVKNARALAQALQERGFELVAGGTDTHLILVDLRNKGLTGAVAEDLLDRVDVTVNKNMVPFDPQPPRVTSGIRIGTPAVTTRGMKEDSMVQIAEVISLTLDHPEEGAVQARAKAIVAELCAAHPFLKL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_CAMJE
Sequence: MNFQPLGKRVLVKRVEETKTTASGIIIPDNAKEKPLMGEVVAVSKEITDIANGDKIVFAKYGGTEIKLDNNEYLVLNLDDILGILK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_BACCZ
Sequence: MKKILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RL332_MYCGI
Sequence: MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLEIKKFCPNCGKHQAHKESR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: IFNG_TURTR
Sequence: MKYTSYFLAFQLCVILGSSGSYCQAPFFKEIQNLKEYFNASNPDVAGGGPLFLEILENWKDESDKKIIQSQIVSFYFKLFENLKGNQIIQRSMDIIKQDMFQKFLNGSSEKLDDFKKLIQIPVDDLQIQRKAISELIRVMKDLSPRSNLRKRRRSQNLFRGQRASK
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROK_RALSO
Sequence: MSVSNVFFVGLMGAGKTTVGRAVARRLDLPFFDSDHEIEARCGVRVPVIFEHEGEMGFRDRETQMIDELTARHGVVVATGGGAVLRPENRAFLRERGTVIYLRANPHDLYLRTRHDKNRPLLQTENPRARLEELHAIRDPLYREVAHFVIETGKPTVAQLVNMVLMQLEVAGIVVPPAASSPTSQVSRQS
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_PSEAB
Sequence: MKANELREKSVEQLNEQLLGLLRDQFNLRMQKATGQLGQSHLLSQVKRDIARVKTVLNQQAGK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: AROC_SULIN
Sequence: MPGNSFGKLFRVTTFGESHGPAVGVVIDGVPAGLPLTVEDIKFELEFRKPGRLYVSGRREKDEPEILSGIFNNRTTGSPIAVIVRNTDVISSFYEEIRYKPRPGHADLPFIMKYGYENWDYRGGGRASARETVGRVIAGAVAKKLLMLADTWIAGHLRSLGPEELNEEVTFEEVLCSKYSPVRASKKVLEEKYEALIKKATQEGDSYGGIAEVITKNPPIGLGEPVFDKMKAELAKAIMSIPAVTGFEYGLGFMVSKMKGSEANDEIIRKDNKIGWKYNYAGGILGGLTNGEDLIVRCAFKPTSSIRKPQKTIDLRNLEETYISVIGRHDPAVAIRGVTVVESMVALTLVDHAMRAGVIPLVKLTEEQGNIVQQRWERYVRSCKPMEESQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.