PharMolix/UniProtQA huggingface dataset:
Protein: DADA_XYLFT
Sequence: MRVLILGSGVIGTTSAWYLSKAGCEVVVVDRQSGAGLETSYANGGQLSFGYTSPWAAPGVPLKAVRWLFERHAPLSIRPTTDWNQYVWLARMLRHCSAERYAVNKSRMLRLSEYSREALEALSAETGITFEGRRLGTIQLFRTQQQLDGAVRDIELLTQYGIPYEVLSPHQLAKFEPGLADGSVRFVGALRLPHDQTGDCCLFTQRLAALAAKRGVEFRYGCTVQRLEVDGPRVTGAWINGALERADCCVVALGSYSPLLLAPLGLRLPVYPLKGFSLTLPMIDASRAPVSTVLDESYKVAVTRFDERIRVAGMAEVSGYDVSLNPRRRSTLEMVVQDVYPGCGDLGRGEFWTGLRPATPDGTPVIGATPYQGLFLNTGHGTLGWTMSSGSGRYLADLICCRPCEISSEGLDMFRYLVSTIPCPQECAPCVPPTP
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: NSP4_ROTAD
Sequence: MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCIVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDNLITRPVDVIDMSKEFNQKNIKTLDEWESGKNPYEPSEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: MTP9_ARATH
Sequence: MAATEHRGLSGGDYNVDLLPIDQDDSPPSSWRLSLDTFRLPSSSPLSSGRHNGRTRLSRYLRTPKKERKVSEYYKQQEKLLEGFNEMETINETGFVSGAPTEEELKKLAKSERLAVHISNAANLVLFVAKVYASVESRSMAVIASTLDSLLDLLSGFILWFTANAMRTPNNFRYPIGKRRMQPVGIIVFASVMATLGLQVILESTRLLVSKNGSHMSSTEEKWMIGIMASATVVKFLLMLYCRSFQNEIVRAYAQDHLFDVITNSVGLATAVLAVKFYWWIDPSGAILIALYTISTWARTVLENVHSLIGRSAPPDFLAKLTFLIWNHHEKIKHIDTVRAYTFGSHYFVEVDIVLPEDMRLHEAHNIGETLQEKLEQLSEVERAFVHIDFEFTHRPEHKCKV
What is the function of this protein?
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
What are the official names of this protein?
Metal tolerance protein 9, AtMTP9.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: ACKA_ECOL6
Sequence: MSSKLVLVLNCGSSSLKFAIIDAVNGEEYLSGLAECFHLPEARIKWKMDGNKQEAALGAGAAHSEALNFIVNTILAQKPELSAQLTAIGHRIVHGGEKYTSSVVIDESVIQGIKDAASFAPLHNPAHLIGIEEALKSFPQLKDKNVAVFDTAFHQTMPEESYLYALPYNLYKEHGIRRYGAHGTSHFYVTQEAAKMLNKPVEELNIITCHLGNGGSVSAIRNGKCVDTSMGLTPLEGLVMGTRSGDIDPAIIFHLHDTLGMSVDAINKLLTKESGLLGLTEVTSDCRYVEDNYATKEDAKRAMDVYCHRLAKYIGAYTALMDGRLDAVVFTGGIGENAAMVRELSLGKLGVLGFEVDHERNLAARFGKSGFINKEGTRPAVVIPTNEELVIAQDASRLTA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_VIBCH
Sequence: MPRRRVIGQRKILPDPKFKSELLAKFVNILMVDGKKSTAEKIVYTALDTMAEKSGKDHLAVFEEALENVRPAVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWLVEAARKRGEKSMAARLAAEMLDAAENKGSAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: NAGAB_RALSP
Sequence: MTQNWIDAACLDDIPEGDVVGVKVNGKEIALYEVEGEIYATDNLCTHGAARMSDGFLEGREIECPLHQGRFDVCTGKALCTPLTKDIKTYPVKIENMRVMLKME
What is the function of this protein?
Component of two multicomponent enzyme systems which are involved in the catabolism of naphthalene (PubMed:11872705, PubMed:9573207).  Plays a role as an electron transfer component for both salicylate 5-hydroxylase (S5H) and naphthalene 1,2-dioxygenase (NDO) systems, by transferring electrons to the oxygenase components (PubMed:11872705, PubMed:9573207).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase/salicylate 5-hydroxylase systems, ferredoxin component, NDO/S5H systems ferredoxin component, Ferredoxin NagAb.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: RL2_MESH2
Sequence: MALKYYKPTTNGRRHMSSLDFGANLTTNKPEKSLLTILKKHSGRNSQGKITVRHQGGRHKRKYRLIDFKRNKDDIPGIVKTIEYDPNRSANIALISYIDGEKRYILAPKNLKVGQKISSGPKSDILVGNALPLAKIPEGTFVHNIELKPGAGAKLIRSAGTWAQIQGRDEDGKYVILKLKSGEYRRILATCRATIGVVGNEENSLVNIGKAGRNRHKGIRPTVRGSVMNPNDHPHGGGEGKQPIGRKSPLTPWGKKALGVKTRNPKKPSTKLIIRSRKETKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: FMT_CALS4
Sequence: MRIVFMGTPEFAVPSLKRLFEEGYDVLAVVTQPDKQRGRGMKVSFSPVKELALQKGVKVLQPESVKNNPEFLQELKELNPEVIVVAAYGKILPEEILTLPEYGCINVHASLLPKYRGAAPINWAIINGEKETGITTMLMDKGLDTGDMLLKRSIAIEEDDDAQTLHDKLANLGAEVLSETLKKLKEGKLIPEKQKDEEATYAPIITKEMGHIDWKSPACRIRNLIRGLKPWPGCYTFYDGKMLKIWKAEVVEHFGNEPPGSVLKSKDELIVKCGENALRILEIQQEGSRKMGIREYLIGHNIPEGTILK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: Y1705_METHJ
Sequence: MKITYLGHACVVLQGSKCVLIDPFIPEGEIRVTPDLVAVTHAHADHMGIAASYTAPIITNNEIAHYLRGKGCITEAMNIGGTIVVDGISFTMTQAIHSSWLEDEGIGMYGGSAAGFVISMDGRTVYHAGDTGLFSDMRLIGELYHPDVALIPIGGRFTMGPREGMMAAEFIGAPVVIPIHYNTFDKIRQDVSEFARAINETTDMKTVILEPGMEYEIKK
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Mhun_1705.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: IRB10_MOUSE
Sequence: MGQSSSKPDAKAHNMASSLTEFFKNFKMESKIISKETIDSIQSCIQEGDIQKVISIINAALTDIEKAPLNIAVTGETGAGKSTFINALRGIGHEESESAESGAVETTKDRKKYTHPKFPNVTIWDLPGVGTTNFKPEEYLKKMKFQEYDFFLIISSARFRDNEAQLAEAIKKMKKKFYFVRTKIDSDLWNEKKAKPSSYNREKILEVIRSDCVKNLQNANAASTRVFLVSSFEVAQFDFPSLESTLLEELPAHKRHIFVQCLPTITEPAIDRRRDVLKQTIWLEALKAGASATIPMMSFFNDDIEEFEKILSHYRACFGLDDESLENMAKEWSMSVEELESTIKSPHLLSSEPNESVADKLVKTMEKIFAVTGGFVATGLYFRKSYYMQNYFLDTVTEDAKVLLKKKVFLQDSVDSE
What is the function of this protein?
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens by mediating cytosolic release of pathogenic ligands that activate the inflammasomes (PubMed:16959883, PubMed:20109161, PubMed:27693356, PubMed:30062052, PubMed:30510167, PubMed:34694641).  Following infection, recruited to the membrane of pathogens in a GBP-dependent manner and mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:27693356, PubMed:30062052, PubMed:30510167).  Promotes AIM2 and NLRP3 inflammasome activation following A. fumigatus infection by liberating beta-glucan, which directly triggers inflammasome assembly (PubMed:30510167).  Promotes NLRP3 inflammasome activation following influenza A virus infection (PubMed:34694641).
What are the official names of this protein?
Interferon-gamma-inducible GTPase 10, Irgb10.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
Protein: Y1617_MYCBO
Sequence: MLGLSATGVLVGGLWAWIAPPIHAVVAITRAGERVHEYLGSESQNFFIAPFMLLGLLSVLAVVASALMWQWREHRGPQMVAGLSIGLTTAAAIAAGVGALVVRLRYGALDFDTVPLSRGDHALTYVTQAPPVFFARRPLQIALTLMWPAGIASLVYALLAAGTARDDLGGYPAVDPSSNARTEALETPQAPVS
What are the official names of this protein?
Uncharacterized protein Mb1617.
What is the protein family that this protein belongs to?
To M.leprae ML1222.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1466_MARMM
Sequence: MTIYVDADACPVKDEIIRVGERHQTEMLFVCDGGLRRPNSQWARLVIVEGKLDAADDWIADHIGAGDVFVTADIPLADRCIKAGAIGIDPRGKLWTQDNIGASLATRNLMTDLRETGAVTSGAKPFGPKDRSSFLDGMERVMRAAAAKKA
What are the official names of this protein?
UPF0178 protein Mmar10_1466.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RS15_HALSA
Sequence: MARMHTRRRGSSGSDRPTADEPPEWSDVDEDAIEERVVELAEQGHDPSQIGLKLRDEGVQGTPVPDVKLATGKKVTEILEAHDAEPELPEDFRNLLEKAVRLHEHVEANGQDHQNKRALQNTQSKIRRLADYYRGDKLDEEFAYSYETAREIIEE
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CYB_SORSU
Sequence: MTNLRKTHPLMKIINNSFIDLPAPSNISSWWNFGSLLGICLIVQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGIYYGSYMFLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIVAALAGVHLLFLHETGSNNPSGLPSDADKIPFHPYYTIKDILGVLLFILILTSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAVIPLLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVLMPIASLLENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AOXD_MOUSE
Sequence: MPSVSESDELIFFVNGKKVIEKNPDPEKNLLFYTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPATACLVPICWLHGAAITTVEGVGSIKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNHPEPTPDQITEALGGNLCRCTGYRPIVESGKTFSQKSTVCQMKGSGKCCMDPDEKCLESREKKMCTKLYNEDEFQPFDPSQEPIFPPELIRMAEDPNKRRLTFQGKRTTWIIPVTLNDLLELKASYPEAPLVMGNTTVGPGIKFNDEFYPVFISPLGVPELNLMDTTNNGVTIGAGYSLAQLKDTLDFLVSEQPKEKTKTFHALQKHLRTLAGPQIRNMATLGGHTASRPNFSDLNPILAAGNATINVVSREGKDRQLPLNGPFLEKLPEADLKPEEVILSIFIPYTAQWQFVSGLRLAQRQENAFAIVNAGMSVEFEEGTNTIKDLKMFFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVLQEIRIPPDAEGGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPDIPGKFVSALDDFPIETPQGIQMFQCVDPKQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKITSLDVSEALACPGVVDVITAEDVPGENDHNGEILYAQSEVICVGQIICTVAADTYIHAKEAAKRVKIAYDDIEPTIITIEEALEHNSFLSPEKKIEQGNVDYAFKHVDQIVEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKRAGGAFGGKVTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAGRHPLLGKYKIGFMNNGEIRAADVEYYTNGGCTPDESELVIEFVVLKSENTYHIPNFRCRGRACKTNLPSNTAFRGFGFPQATVVVEAYIAAVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAAEEFNGNNYWKKRGLAVVPMKFSVAVPIAFYNQAAALVHIFLDGSVLLTHGGCELGQGLHTKMIQVASRELNVPKSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPIIRKNPKGKWEEWIKMAFEESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFVDAAFSINPALDIGQVEGAFIQGMGFYTTEELKYSPKGVLYSRGPEDYKIPTITEIPEEFYVTLVHSRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGLSDIFPLNSPATPEVIRMACTDQFTEMIPRDDPSTFTPWSIHVS
What is the function of this protein?
Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate.  Is responsible for the major all-trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin.  Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases.  Acts as a negative modulator of the epidermal trophism.  May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles.
What are the official names of this protein?
Aldehyde oxidase 4, Aldehyde oxidase homolog 2, Azaheterocycle hydroxylase 4, Retinal oxidase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BDNF_AILME
Sequence: MTILFLTMVISYFGCMKAAPMKEANVRGQGSLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2.  Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2.  Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).  Binding to NGFR and SORCS2 promotes neuronal apoptosis.  Promotes neuronal growth cone collapse.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: RUVB_FLAPJ
Sequence: MNENLDPTNQKYNPEELDLEKKLRPLSFDDFTGQEQVLENLKIFVQAANLRGEALDHTLFHGPPGLGKTTLANILANELGVGIKITSGPVLDKPGDLAGLLTNLDERDVLFIDEIHRLSPIVEEYLYSAMEDFKIDIMIESGPNARSVQINLSPFTLVGATTRSGLLTAPMRARFGIQSRLQYYNAELLTTIVQRSSSILKMPITMEAAIEIAGRSRGTPRIANAMLRRVRDFAQIKGNGSIDIEIAKFALNALHVDAHGLDEMDNKILNTIIDKFKGGPVGLSTLATAVSESSETIEEVYEPFLIQEGFIMRTPRGREVTEKAYKHLGKVKANVQGGLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LUKDV_STAA8
Sequence: MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMPLLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDSKETNPGV
What is the function of this protein?
Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells.  The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL).  LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin.
What are the official names of this protein?
Leucotoxin LukDv, Variant of LukD.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GCST_CHLTE
Sequence: MKKTALSAWHEAAGAKMIDFGGFLMPVQYTGIIAEHKAVREAAGLFDVSHMGNFYVRGARALEFLQYMTTNDLAKIVDGQAQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDFDWLSSHIGQFEGVALENHTSELSLIALQGPKSFDILARVFPGAGIDKLGSFHFIKLPFEGAEIMVARTGYTGEAGVEICLPNERAVALWSALMEAGKSDGIQPIGLGARDTLRLEMGYSLYGHEIERDVNPLEARLKWVVKLNKPNFIGKQACEQVEINPRKSVVGFSLEGRAIPRQHFKVYNSDKQEIGEVCSGTVSPTLQEPIGTASLLLDYAQPGTPIFVEIRGTMQPGAVRRLPFVHADRP
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RIFK_PYRHO
Sequence: MKLKTLLLLIDLGKRGAIGGKITITLREISKELDVSPQTTLRWLEELEELGYIEKEESRRGTSVMITEKGIRLLEKLYEDISIALYSGVIVGEVISGIGEGAYYVRQYAPFIREYLGFDPYPGTLNVKVIFPKTIFDALCTSRPIIIPGFKKNGRTFGDVRAYRIKIDGIEGAIVIPSRTVHPPKIAEVIAPVNLRKTLNLQDGDKVRIKVL
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: TMG3_MOUSE
Sequence: MAVFLEAKNAHAVLKRFPRANEFLEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGYPNAVYSVRDPSQSSDAMYVVVPLLGVVLLIVIALFIIWRCQLQKATRHHPSYAQNRYLASRAGHNLPRVMVYRGTVHSQGESSGHREAGNNPQIVMGPSRGGRTTVRLESTLYLPELSLSRLSSATPPPSYEEVTAPQEGSSEEASVSYSDPPPKYEEIVAASPSADK
What are the official names of this protein?
Transmembrane gamma-carboxyglutamic acid protein 3, Proline-rich gamma-carboxyglutamic acid protein 3, Proline-rich Gla protein 3.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RBFA_MYCPA
Sequence: MPDPARARRLAKRINTIVASAIEFEIKDPGLDGVTIVDTKVTADLHDATVFYTVMGRTLDDEPDYGAAAAALERAKGALRTMVGAGTGVRFTPTLTFTRDTTSDSVARMDELLARARAADADLARVRSGAKPAGEADPYRESGSGVEPGRDGSIGDDDQPEY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_THEM4
Sequence: MKKIILALIRFYQKFISPLKPPTCIYTPTCSEYTYQAVKKFGVFKGLFLGFKRILRCNPLHEGGEDPVPDKFYIIKGRRLD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XKR6_RAT
Sequence: MAAKSDGGGVGVGFAQLHNLDEAVGSGEEDGEPGGGGCGGGDGSEPGESSSLHICHCCNTSSCYWGCRSACLRSLLGKKPRRSAAAADGGDQPLQPPGAAGRHPPTPSAGRPQPASPQVERPWLDCLWIVLALLVFFGDVGTDLWLALDYYRKGDYGCFGLTLFFVLVPSLLVQSLSFRWFVQDYTGGGLGAVEGLSSRGPPMMGAGYGHGAARGGPGAGGSATPGAQRLCRLSVWIWQSVIHLLQMGQVWRYIRTMYLGIQSQRQKEHQRRFYWAMMYEYADVNMLRLLETFLESAPQLVLQLCIMIQKNSAETLPCVSSVTSLMSLAWVLASYHKLLRDSRDDKKSMSYRGALIHLFWRLFTISSRVISFALFASIFQLYFGIFVVVHWCAMAFWIIHGGTDFCMSKWEEILFNMVVGIVYIFCWFNVKEGRTRYRMFAYYTIVLTENAALTFLWYFYRNPESTDSYAVPALCCVFVSFVAGITLMLLYYGVLHPMGPRAKVFASSCCAELLWGIPLPPDVEPMAPQTPGYRGTQVTPTRAVTEQQEDLTADTCLPVFQVRPMGPSTPSGRPYHPEGPLIKIDMPRKRYPAWDAHFVDRRLRRTINILQYVTPTAVGIRYRDGPLLYELLQYESSL
What are the official names of this protein?
XK-related protein 6.
What is the protein family that this protein belongs to?
Belongs to the XK family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL19_ANADE
Sequence: MLRKAIADIEAKYLRTDLPEMRAGDSVRVHTKIKEGDKERIQVFEGVVIAYRKGAPGSSMFTVRKVSYGVGVERMFPVHSPRIDKIEVVGHGGVRRSRLYFLRNLQGKAARLHQEEGPGAADAAHAAPTPA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATG16_ASPFU
Sequence: MAHWRNEYSAALAARDRREKANVALYNASDRTSRIASTGAQGAQYLTGTGDKHTAIPAAGKSLAGPSVPDILAATRADLSEAQRARSELQARLTELSTELEKLRKRSTQDSRRIHVLESEDFQDELASLNLQLNMAEERSSRLQRENRELIDRWMARIGREAEAMNDASKFS
What is the function of this protein?
Stabilizes the atg5-atg12 conjugate which is necessary for autophagy.  The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS).  Recruits also atg3 to the PAS.  Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
What are the official names of this protein?
Autophagy protein 16.
What is the protein family that this protein belongs to?
Belongs to the ATG16 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: PTH_SHESM
Sequence: MSEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQELINAAVDEAVRSTEVLFKEDMVKAMTRLHSFKAE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.