PharMolix/UniProtQA huggingface dataset:
Protein: PROB_PSEMY
Sequence: MRDKVTGARRWVVKIGSALLTADGRGLDRAAMAVWVKQMVALREQGVELVLVSSGAVAAGMSRLGWTSRPSAMHELQAAAAIGQMALVQAWESSFAEHGRRTAQILLTHDDLSDRKRYLNARSTLRTLVGLDVIPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMYTADPRHNPDAELIHEARADDPALDAVAGGVGGALGRGGMQTKLRASRLAARSGAHTVIVGGAIEQVLARLKAGERLGTLLAPERGLLAARKQWLAGHLQTRGTLVLDAGAVKALSQDRKSLLPVGVKAVQGSFRRGEMVVCVAPDGREVARGLVNYSALEAQKIIGQPSDAIEKLLGYVDEPELVHRDNLILV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27A_XENLA
Sequence: MPSKLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKKNQSFCPTINLDKLWTLVSEQTRLNHAKNLEGPAPIIDAVHAGYYKVLGKGKLPKQPVIVKAKFFSRKAEEKIKSVGGACVLGA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L27a, L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_PECAS
Sequence: MSDDASTLLRTISWFTEPPSVLPEHIGDWLMETSSMTQRLEKYCAQLRVTLCREGFITPQMLGEERDQLPADERYWLREVVLYGDDRPWLFGRTIVPQQTLEGSGAALTKIGNQPLGRYLFEQKSLTRDYIHTGCCEGLWARRSRLCLSGHPLLLTELFLPESPVYYTPGDEGWQVI
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y8853_DICDI
Sequence: MKDYEIVFTVFSSIIFAFLLFRLCKFCCVFCCALCNVPDNVYGRKRPRGSIVVEENEDDGNGEKEGLLNV
What are the official names of this protein?
Putative uncharacterized protein DDB_G0272506.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NU4LM_ECHGY
Sequence: MQMTMINMILAFIMATTGLLMFRSHFMSSLLCLEGMMLSIFILMSISTLNFNNSLAMMFPLVLLVFAACEAAIGLSLLVKISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADK_ECOUT
Sequence: MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCTKGYEVIVEQQIAHELQLKNVKTGTLAEIGQQADLAVVVGGDGNMLGAARTLARYDIKVIGINRGNLGFLTDLDPDNAQQQLADVLEGHYISEKRFLLEAQVCQQDCQKRISTAINEVVLHPGKVAHMIEFEVYIDEIFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRNDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENG_CORK4
Sequence: MARATLEKKPREVARMFDAVGKKYDLTNTVLTGGIDTLWRKATRKRLDPKPGEKVVDLAAGTGVSTAELSKSGALVVGCDFSLGMLKAGRHRNVPLVAGDGLNLPFADNTFDAATISFGLRNFGDTAAGLREIARVVKPGGRLTVCEFSTPVIPVFSTIYTEYLMRALPTVAKIVSSDPESYVYLAESIRAWPDQETLARIIQSAGWKEVGWRNLTGGIVALHSATKPR
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: IHFA_SALG2
Sequence: MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKEE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RPOA_LACLA
Sequence: MIEFEKPKITKFDESENYGKFVVEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIQIEGVQHEFATIPGVREDVIQIVLAVKGIAIKSYVESEKQIELDVTGPMDVTAGDILTDSDIEIVNKDHYLFSIAEGHSMRAVMTVKKGYGYVPDDENKVDGAPIGTIAVDSIYTPVSKVNYQVEPARVGGDSSYDKLTLEITTNGTIVSDEALSLSAKILTDHLNLFVDLSEVAAEAETLVVKDEVKTERVLDKIIEEMDFSVRAYNGLKRAGINTVADIVEMSEADMIKVKNLGHKSVEEVKVKLTELGLSLKKRK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RR18_LIRTU
Sequence: MDKSKRLFRKSKRSFRRRLPPIGSGDRIDYRNMSLISQFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSSLPFLNNEKQFEKTESIPRTTGPRTRNK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLPE_YERPG
Sequence: MEQFEAISVEQAYLRWKEGKTALVDIRDPQSYEAGHAPGAFHLTNSSLHTFMQQTDFDQPVMVMCYHGNSSKGAAQYLLQQGFDVVYSIDGGFEAWARSYPQDITSESR
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3L237_OPHHA
Sequence: MKTLLLTLVVMTIVCLDLGYSLICFISPHDSVTCAPGENVCFLKSWCDAWCGSRGKKLSFGCAATCPKVNPGIDIECCSTDNCNPHPKLRP
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin OH-37.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MLTC_ECO7I
Sequence: MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENFWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: ZN853_HUMAN
Sequence: MLHQPTPGNRGLTARMEVGPATETFVLELQCLEDGGPGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQELMVLPAVAAPAVVAIPGPAGSAALTPARQRRRRRARDRPTICGECGKGFSRSTDLVRHQATHTGERPHRCGECGKGFSQHSNLVTHQRIHTGEKPYACSYCAKRFSESSALVQHQRTHTGERPYACGDCGKRFSVSSNLLRHRRTHSGERPYVCEDCGERFRHKVQIRRHERQLHGAGRSRGLGLLRASRPAALGGPARAEQAATATAPADKAL
What are the official names of this protein?
Zinc finger protein 853.
Protein: SYE_PSYA2
Sequence: MMQPSTSTNSNRPVRTRIAPSPTGFPHVGTAYIALFNLAFAKAHGGEFILRIEDTDQTRSTEQSEKMILDALRWVGLDWSEGPDVGGPHAPYRQSERSAIYKKHAEQLIDSDHAFRCFCTSEELDTMRAEQMANGETPRYDGRCAHLATEKTEQLVKEGKPNVIRMRVPTEGVCQVQDMLRGTVEIPWTQVDMQVLLKTDGMPTYHLANVVDDHLMDISHVLRGEEWLNSAPKHQLLYEYFGWEMPVLCHMPLLRNPDKSKLSKRKNPTSITYYRDAGVLPEALLNYLGRMGYSMPDEAEKFTLDEMIASLDIQRVSLGGPIFDIEKLNWLNAEWLRALTPEELKNKILDWASNSDKLTAIAAAIQPRIELLSDAVNWSGFYFQNLPDINAESFTHKSLTAEQIIEMLQLALWQLETLPTWSEENIYATLKGLAAHLDIKMRDFMAPFFIAIAGSTSSTPVMNSMAIIGADMTLTRLRHAVDVLGGLGKKKLKKLEKQAAELPDFLAAE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_NEUCR
Sequence: MSEPKNKRQKREDYRAALRANGVTELPRKKFYRQRAHANPFSDHSLIYPPTPEQMDWASLYPHYAVEEPIEQKTETTESEESTGQELSAPAIRKLTKQVEVADIGCGFGGLLIALAPVLPETLVLGLEIRVSVTQFVEDRIKALRVQNEEQKLYRNIAVLRANTMKFMPNFFNKGQLNKIFICFPDPHFKARKHKQRIVSTTLNSEYAYVLRPGGIVYTITDVPDLHEWMVGHFNAHPAFERVSVEEQEADPLVEIMRNETEEGKKVTRHNGQKHVALFRRLEDPQWPEDVSA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUD_PSYWF
Sequence: MQAYNTQTGIVCPLDRSNVDTDQIIPKQFLKSIKRTGFGVNLFDDWRYLDEGFPGQDNSKRPINPDFVLNKPRYQGATILLARDNFGCGSSREHAPWALSEYGFRTVIAPSFADIFYNNCFKNGMLPIVLTEAQVDDLFEQCLANEGYELTADLERQVVVTPDGTEYPFEVDEFRKHCLLNGLDDIGLTLQQSEAIKAYEAKMQQNTPWIFKEVRA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: STAR6_HUMAN
Sequence: MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS
What is the function of this protein?
May be involved in the intracellular transport of sterols or other lipids.  May bind cholesterol or other sterols (By similarity).
What are the official names of this protein?
StAR-related lipid transfer protein 6, START domain-containing protein 6, StARD6.
Protein: Y1765_BRUA2
Sequence: MSDDITSEAQTIAVGQLRAFIERIERLEEEKKTIGDDIKEVYAELKGSGFDSKVVRTIIRLRKKEDHERQEEEAMLQLYMDALGMS
What are the official names of this protein?
UPF0335 protein BAB1_1765.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: HEMH_ECO45
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRSVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALEMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC24_DICDI
Sequence: MTSKRQYPIDQSNQLSQGQNPSPQQPLQQYPQQPYQPNPTYGNDTTQQWNQTPQQQQQPQQQNISPPQSQNQNGVQNTIHTGGSKRVYPVDPQNETLLSSNFSNMNLSSQQQQPLPQPTHIPVPGPNTTTYNPYIQQPQQQPQQQPQQQPQQPQQPQQQPQQQTQQPQTWNTSPPQTQQQPIQTFTPHISPPQTQQQQPQQTTPFQPMQPTQPSYSQPQQTQPLPLPPMQPSYNQQPYTQQPYTQQPYTQQPGQQSQYQQPQQQTPQQQAAVEQPVPTLENLCPKPFMRLSMNAIPNHPSILNKVHIPLGLNIHPLAHDPQGPVPVVYSSIIRCRRCRTYINPFVTWLNGGGRWRCNMCENINDTPQDYFSPIDFTTGKRSDILNRPELQKGCVEFLASSDYLVRPPQPPTYFFIVDVCYESIVSGMLNTAINAIKTTLGDLIEKSNGRARFGIMTFDDSLHFYNLKSNPSNRPQMFVVTDMDQVYVPPFEDFLVNLKDGLEVVENTLNIIQSMPRTQQKVESCLGSALKAAFSICERVGGKLIVLQSYIPRGPLGKLSIRDYQPLLGTKKESTLLQPSNDGEFYKELALSCTSQQLSVDLFLFSNDYTDTASLGTLCQITGGSMYYYPSFVASRDGQVFAANLIHSLTRDTAWEAVMRVRTSRGLTINSYHGNYFLKTSDLLGLPTIDSDKTITLQMGISDSIGQKYASLQSALLYTHSCGERRVRVFTISIPVVSNYQDLFRYADISVVTSLISKMAIDKALSSSLNDARDAIANKCVEILQAFKAASTSNPQANPAVTLSQNAPKLLLPETLKHLPLYVVSMVKSIIFSSRTTHPDLRAFHMQRMKTLDLNSCLNFFYPYFYSLLAPPNYQPPTTPNTPFVPHSFKLSSDELQRNGLFAIVNGYTLYLFIGEQLPQPVFTDIFGVPDVSQLDINTFQDLPILDNDHSRYARKVIELVRNSYPEYLKMFVVKSTDRQRRPEFQSLLIEDRTPEGCSYYEFIIQLQSRITQN
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC24.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XPT_STRZP
Sequence: MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGRVFAEKFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQDGRDLLEKAGYPVLSLARLDRFENGQVVFKEADL
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGPS_SYNP2
Sequence: MKSSLVILYHREPYDEVRENGKTFYRDKTSPNGIMPTLKSFFANAEQSTWVAWKQISGKQQENFQAKMAFPGQENSVVHRIPLSADQVKNFYHITSKEAFWPILHSFPWQFTYDSSDWENFKQINEMFAEAACEDADDDALFWVHDYNLWLTPYFIRQKKPNAKIAFFHHTPFPSVDIFNILPWREAIVDSLLCCDLCGFHLPRYVQNFVAVARSLRKVEITRQVPVDEHAFTAVGTALAEPEITTQLKYKDHLVNLDAFPVGTNPTQIRAQVEKASTQERIRKIREELGSNKLILSAGRVDYVKGTKEMLVCYERLLERRPELQTKVNLVVAAAKAASGMRVYKNAQSEIERLVGRINGRFAKLNWTPILLFTSALSYEELLGFFGAADIAWITPLRDGLNLVAKEYVVAHGCDDGVLILSEFAGSAVELPDAILTNPYAAKRMDESIDQALAMPVEEQQRRMKSMYQAIQRYDVQQWANHMFREAKATAVLGKEPTPV
What is the function of this protein?
Involved in salt tolerance by producing GG-phosphate from ADP-glucose and glycerol-3-phosphate (G3P), an intermediate in the synthesis of the osmolyte glucosylglycerol (GG).
What are the official names of this protein?
Glucosylglycerol-phosphate synthase, Glucosyl-glycerol-phosphate synthase, GG-phosphate synthase, GGPS.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: PSN1_PONAB
Sequence: MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGSSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGGPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
What is the function of this protein?
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the presence of the other members of the gamma-secretase complex for protease activity.  Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.  Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin).  Under conditions of apoptosis or calcium influx, cleaves CDH1.  This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity).  Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).  Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity).  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis.  Involved in the regulation of neurite outgrowth (By similarity).  Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity.  It acts through the control of SYT7 presynaptic expression (By similarity).
What are the official names of this protein?
Presenilin-1, PS-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane; Multi-pass membrane protein. Cell projection, growth cone. Early endosome. Early endosome membrane; Multi-pass membrane protein. Cell projection, neuron projection. Cell projection, axon. Synapse. Note=Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. Colocalizes with UBQLN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes.
Protein: GLYA1_PSEAE
Sequence: MFSKHDQIRGYDDELLAAMDAEEARQEDHLELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVERLAIDRARQLFGADYANVQPHSGSSANAAVYLALLNAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGLDTATGLIDYDEVERLAVEHKPKMIVAGFSAYSKTLDFPRFRAIADKVGALLFVDMAHVAGLVAAGLYPNPIPFADVVTTTTHKTLRGPRGGLILARANEEIEKKLNSAVFPGAQGGPLMHVIAAKAVCFKEALEPGFKDYQAQVIRNAKAMAEVFIGRGYDVVSGGTDNHLMLISLVRQGLTGKEADAALGRVGITVNKNAVPNDPQSPFVTSGIRIGTPAITTRGLQEAQSRELAGWICDILDHLGDADVEAKVATQVAGLCADFPVYR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_BACC3
Sequence: MKVLQEKILNEGKVLSGDVLKVDAFLNHQIDPVLMQEIGKEFAKRFKEENITKIVTIESSGIAPAVMAALELGVKVIFARKRKSLTLQDNMYVANVYSFTKQETNEISLSRNHIDESDRVLIIDDFLANGQAALGLMSLVEQAGASIAGIGIVIEKAFQDGGKKLREQGVRVESLAEIASLGNGTVTFVQHETAEVK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS24_SPOFR
Sequence: MTEGTATIRTRKFMTNRLLARKQMVCDVLHPGKPTVSKTEIREKLAKMYKVTPDVVFVFGFKTNFGGGKSTGFALIYDTLDLAKKFEPKHRLARHGLYEKKRPTRKQRKERKNRMKKVRGTKKSKVGAAAKK
What are the official names of this protein?
40S ribosomal protein S24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: PUR7_GEOUR
Sequence: MSKLVLTTDFPDLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPDKGYVLTQISAFWFRQMEDIIPNHIISTEVKDFPAECQKYADVLEGRSMLVKKAKPLPAECIVRGYISGSGWKDYQATGSVCGITLPAGLKESDRLPEPIFTPSTKAELGTHDENISFEKMVDMCGKDIAEKVRDITLKIYKKARDIADGKGIIIADTKFEYGIYEGELIIIDECMTPDSSRFWPKDSYQPGGPQPSFDKQFLRDYLETLDWDKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: BTGC_ASPTN
Sequence: MSGDPRSFSFNQGDDHPIDSSQQPLHPTNTMADSYSDRNWGAPGGLDHTHSMRTQSTATPGMDNLGPAAVGGGISGIALGVANSHDRQSGVDAFRDTDGGNFPAERGYNAPGSDNPYVPPPPAAAYDSSDNLTARSGAYGSSAALAAAASAPAGASNTSRRSFVDSPYQGVGALDAGPYQRQSVYNNGDYPLVINPDEIIDDGDDGFALPNSKSAGHKSRAVPAAAAGAAGGAAAGGLLGGIFKSKAAAEGPSYGPVPGAGIEAAEKGQWAKPKPGTGSRKRGWIVGIILAVVIVGAIVGGAVGGTLGNREKESPSSSETASGDEKVNGDLGKDSDEIKSLMNNPNLHKVFPGMDYTPWGTQYPLCQKYPPSQNNVTRDIAVLSQLTNTVRLYGTDCNQTEMVLHAIDRLELTEMKLWLGVWIDTNKTTCERQLNQLYDVLDKTKDHSIFKGAIIGNEALYRAGSSIAEAEKTLISYMTEVRDHFKKNNINIPIATSDLGDNWNAELVKASDVVMANVHPFFAGVSVDLAASWTWDFWNNHNLVLTKGTDKKQIISEVGWPSGGGNDCGDGGNCPNDSAGSVAGIDEMNQFMSDWVCQALDNGTDYFWFEAFDEPWKIVYNTKNENWEDKWGLMDPARNLKDGLKIPDCGGKTAT
What is the function of this protein?
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.  This enzyme may be involved in beta-glucan degradation.  Active on laminarin and lichenan (By similarity).
What are the official names of this protein?
Probable glucan endo-1,3-beta-glucosidase btgC, Endo-1,3-beta-glucanase btgC, Laminarinase btgC.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.