PharMolix/UniProtQA huggingface dataset:
Protein: PYRB_ALKEH
Sequence: MNAQLDNQGRLRHFLTTEGLPRPLLNQILDTAESFTGVIGKSVKKVPLLRGRTVINLFFEPSTRTRTTFELAATRLSADVLNIDVAVSSQSKGESLLDMLRNLEAMQCDAFVVRHGDSGTAEFIARHVRPGVSVLNAGDGRHAHPTQAMLDMFTIRQHKGDFEPLRVAIVGDILHSRVARSQIHALNGLGAGEVRVIAPRTLLPRDVETLGVRVFHDMQAGLRDVDVVMMLRLQRERMRGALLPSEGEYFKLYGLTEEKLSVAHPDAIIMHPGPINRGVEMNSAVADGPRSVILQQVTNGIAVRMALMSMLLGRAGGGEDA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: Y2717_LEGPC
Sequence: MAIISSLANHLLIAMPSLKDPNFERSVVYLCEHNEQGSVGLIINRPLQFPLSIVFEQLQIEPIRVEKNGLPLLFGGPVQPERGFVIHKQMGGWRSSLFLQDEVTVTTSNDIIRAIAYDEGPKDVLITLGYAAWTEQQLEREIMSNTWLVCPYKSEILYEVPFEERWEYAGLTLGIKMNQLSSDAGHA
What are the official names of this protein?
UPF0301 protein LPC_2717.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: WNT4_STRPU
Sequence: SGSCEMKTCWKSMPTFGDIGQVLKEKFDGATEVQSLKIGSRQQLVPTQRDFKPHTSSDLVYLVPSPDFCEEDLKVSIPVGLTFSHPPNQGSLGTHGRRCNKTSKAIDGCELMCCGRGFNTHIEEVIERCSCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Plays an important role in embryonic development (By similarity).
What are the official names of this protein?
Protein Wnt-4.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: AROQ_PROM1
Sequence: MDLLLINGPNLNLVGKREPSIYGSQTLEDIQEELLTLANELGANLKFFQSNSEGEMIDCIQNSVGSIDGILINAGAYTHTSIALRDALLGVAIPYVEVHLSNIYSREEFRHKSFLSDKALGLVCGFGANSYQLALEGIVSYLKRV
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: MTNN_SALG2
Sequence: MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLASTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCYNFSVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RPIA_METPP
Sequence: MNQDELKTLVGRAALEYVPEGSIVGVGTGSTVNCFIDALAGIKERIAGAVSSSVKSTERLREKGIRVFEAAAVESLPVYIDGADEIDPHGCMIKGGGAALTREKIVADLAERFVCIADASKLVDVLGRFPLPVEVLPMAVSQIQRRFAKLGATATVREGVITDNGQLILDVQGLRIGDPLAFETEVNQWPGVVTVGVFARHKASVCLLGTPEGVKTLRF
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RL29_DROME
Sequence: MAKSKNHTNHNQNKKAHRNGIKRPLRKRHESTLGMDVKFLINQRYARKGNLSREESVKRYNERIASQKGKPKPVTL
What are the official names of this protein?
60S ribosomal protein L29, L43.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL29 family.
Protein: CHLN_GLOVI
Sequence: MVSQPTTSSGPQFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDVNAKLNAYDELQRLCLQVKKDRNPSVIVWIGTCTTEIIKMDLEGIAPKLEDEIGIPIVVARANGLDYAFTQGEDTVLAAMASRCPAPQEVRSEEEKKERTGGLRTLFSHGKKDEKKAGPAPSEYVDHQPLVLFGSLTDPVVNQLTLELKKQGIRVSGWLPAPRYTELPIVEQGVTYVAGVNPFLSRTASALQRRMRCNLITTPFPIGPDGTRGWIEAICQALGVIPKGLDEREQQIWDALRDDVEFLKGRSVFFMGDNLLEVSMARFLIRCGMIVHEVGIPYMDKRYQQAELELLDRTCRELGHPPVRIVEKPDNYNQIQRIYACKPDLVITGMAHANPLEARGITTKWSVEFTFAMIHGFTNAHDMLKMVRKPLDRNNALKSLGWEKLIQEV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: TAL1_SALCH
Sequence: MTDKLTSLRQFTTVVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAKQQSSDRAQQVVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRIIKLYNDAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKANTDKKDYAPAEDPGVVSVTEIYEYYKQHGYETVVMGASFRNVGEILELAGCDRLTIAPALLKELAESEGAIERKLSFSGEVKARPERITEAEFLWQHHQDPMAVDKLADGIRKFAVDQEKLEKMIGDLL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase 1.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_STRA5
Sequence: MNNEFINFDRISRENWKDLHQQSQALLTEKELESIKSLNDNINIQDVIDIYLPLINLIQIYKRSQENLSFSKAIFLKKENYQRPFIIGISGSVAVGKSTTSRLLQLLISRTFKDSHVELVTTDGFLYPNEKLIQNGILNRKGFPESYDMESLLNFLDTIKNGITAKIPIYSHEIYDIVPNQLQTIETPDFLILEGINVFQNQQNHRLYMNDYFDFSIYIDAENKQIEEWYLQRFNSLLQLAEADPSNYYHKFTQIPPHKAMELAKDIWKTINLVNLEKYIEPTRNRADFIIHKGKHHKIDEIYLKK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_STRP4
Sequence: MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTRAQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: BTUD_ECO8A
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KHSE_STAES
Sequence: MEEVLKLKIPASTANLGVGFDSIGMALDKYLHMSIRKIERSNWEFLYYSSELEGLPKDENNYIYQTALNVAHKYNVTLPSLQIEMRSDIPLARGLGSSASALVGALFIANYFGNIQLSKYELLQLATEIEGHPDNVAPTIYGGLIAGFYNPITKITDVARIEVPHVDIILTIPPYELRTEDSRRVLPDTFSHKGAVQNSAISNTMICALIQHKYKLAGKMMEQDGFHEPYRQHLIPEFNQVRKLSRQHDAYATVISGAGPTILTLCPKEKSGKLVRTLREKINNCASELVTINEIGVKDEVVYLKS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YB83_SCHPO
Sequence: MNIDEWQRIEETAPGNKCLAKLNELESILKDAKKSCLKDPTTSMKELVACSEKTQQVFDDLKRTEKKFHTSLNRFGKTLEKKFNFDLEDIKLHSSFESKKREIDTALSLHFFRQGDVELAHLFCKEAGIEEPSESLHVFTLLKSIVQGIRDKDLKLPIEWASQCRGYLERKGSSLEYTLQKYRLVSNYLTTKDIMAAIRYCRTNMAEFQKKHLADIQKTMIALFFCSRNEVLSGTNDSHDSIHHIISNNAQLNIPQEYIDVLDLDWKSLELLFVREFCAALGMSLESPLDIVVNAGAIALPILLKMSSIMKKKHTEWTSQGELPVEIFLPSSYHFHSVFTCPVSKEQATEENPPMMMSCGHVIVKESLRQLSRNGSQRFKCPYCPNENVAADAIRVYF
What are the official names of this protein?
LisH domain-containing protein C29A3.03c.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CDD_SHEHH
Sequence: MQDRFLKSIAKLPEPLATAIVPLLDKDFAGHIDAQQLEVLQIASKMELNELLLALLPIAAALARPPISEFHVGAIAKGKSGDIYMGANIELPGEALFHSVHAEQSAISHAWLSGESIIEDIIVNASPCGHCRQFINELVDGSKVKIHLPAQKIEPLAHYLPYAFGPSDLNITEPLLTKQQHTLTLDSNDPMIIEALDHAGLSYAPYTKNYASVVLETKDGATYCGRYAENAAFNPSMQPMQMALSTMARHNRDFSEINRAVLIESSKGVISLVGAAMDALHSVAVVELEHIVVEPE
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RSXE_SALTY
Sequence: MSEIKDIVVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTVSALRRWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPWLSALDGFSIGMGATGAMFVLGSLREILGNGTLFDGADSLLGGWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAVKYLIDEKMKKRRAETAPSAVPAGETGKV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y2615_ACIBT
Sequence: MLPFKLWVDADALPKILREVILRASDRYQLEVIFVANQNVGITPSVRIKSLQVLSGADQADQEIVNRMSENDIVITQDIPLAAQVIEKGGIAIHPRGEVYTTANVKARLHLRDFMDTLRGAGVQTGGPPPISERDKREFSSALDQTILKQKRKTA
What are the official names of this protein?
UPF0178 protein A1S_2615.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RSMG_CITK8
Sequence: MLNKLSRLLDEAGISLTDHQKNQLIAYVDMLHKWNKAYNLTSVRDPNEMLVRHILDSIVMAPHLQGERFIDVGTGPGLPGIPLSIVRPESHFTLLDSLGKRVRFLRQVQHELKLENITPVQSRVEEFPSEPPFDGVISRAFASLDDMLSWCRHLPGENGRFYALKGQLPEEEIASLPAAFSVESVVKLRVPQLEGERHLVVIKPNKI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURZ_BPVC8
Sequence: MKNVDLVIDLQFGSTGKGLIAGYLAEKNGYDTVINANMPNAGHTYINAEGRKWMHKVLPNGIVSPNLKRVMLGAGSVFSINRLMEEIEMSKDLLHDKVAILIHPMATVLDEEAHKKAEVGIATSIGSTGQGSMAAMVEKLQRDPTNNTIVARDVAQYDGRIAQYVCTVEEWDMALMASERILAEGAQGFSLSLNQEFYPYCTSRDCTPARFLADMGIPLPMLNKVIGTARCHPIRVGGTSGGHYPDQEELTWEQLGQVPELTTVTKKVRRVFSFSFIQMQKAMWTCQPDEVFLNFCNYLSPMGWQDIVHQIEVAAQSRYCDAEVKYLGFGPTFNDVELREDVM
What is the function of this protein?
Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate) (PubMed:33926954).  Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP (PubMed:33926955).  dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase.  This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base (PubMed:33926955).  The resulting non-standard viral DNA is called Z-genome (PubMed:33926955).  The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes (Probable).
What are the official names of this protein?
N6-succino-2-amino-2'-deoxyadenylate synthase, 2-amino-2'-deoxyadenylo-succinate synthase, PurZ.
What is the protein family that this protein belongs to?
Belongs to the Caudovirales PurZ family.
Protein: TRPD_NEIM0
Sequence: MITPQQAIERLISNNELFYDEMTDLMRQMMSGKVPPEQIAAILTGLRIKVETVSEITAAAAVMREFATKVPLENAEGLVDIVGTGGDGAKTFNISTTSMFVAAAAGAKVAKHGGRSVSSSSGAADVVEQMGANLNLTPEQVAQSIRQTGIGFMFAPNHHSAMRHVAPVRRSLGFRSIFNILGPLTNPAGAPNQLLGVFHTDLCGILSRVLQQLGSKHVLVVCGEGGLDEITLTGKTRVAELKDGKISEYDIRPEDFGIETRRNLDEIKVANTQESLLKMNEVLEGREGAARDIVLLNTAAALYAGNVAASLSDGISAAREAIDSGRAKSKKEEFVGFQPQQRCHFLGKMELG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TSGA_YERPB
Sequence: MNNSNRIRLTWISYLSYALTGALVIVTGIVMGNIAEYFNLPIASMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLVFGFILMLIAIAGLMVGHNLMIFSISMFIFGVVSGITMSIGTFLVTHMYEGRQRGSRLLFTDSFFSMAGMIFPIAAAMLLARHIEWYWVYACIGLLYVGIFVLTLCSEFPVLGHKATDQSKPVVKEKWGVGVLFLAIAALCYILGQLGFIQWVPEYATKTFNMNISQAGQLVSNFWISYMIGMWIFSFILRFFDLQRIVTVLAAMATLAMYLFVSTDNPAYLSYYILALGFVSSAIYTTLITLGSLQTKVSSPKLVNFILTCGTVGTMLTFVVTGPIVANNGVHAALETANGLYLAVFILCLALGFFTKHRSHGHVTH
What are the official names of this protein?
Protein TsgA homolog.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RR2_SACHY
Sequence: MTRRYWNINLKEMIEAGVHFGHGIKKWNPKMAPYISAKRKGTHITNLARTARFLSEACDLVFDAASQGKSFLIVGTKKRAADLVASAAIRSRCHYVNKKWFSGMLTNWSITKTRLSQFRDLRAEEKMGKFHHLPKRDAAILKRKLSTLQRYLGGIKYMTRLPDIVIVLDQQKEYIALRECAILGIPTISLVDTNCDPDLANISIPANDDTMTSIRLILNKLVFAISEGRSLYIRNR
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PALY_PINTA
Sequence: MVAAAEITQANEVQVKSTGLCTDFGSSGSDPLNWVRAAKAMEGSHFEEVKAMVDSYFGAKEISIEGKSLTISDVAAVARRSQVKVKLDAAAAKSRVEESSNWVLTQMTKGTDTYGVTTGFGATSHRRTNQGAELQKELIRFLNAGVLGKCPENVLSEDTTRAAMLVRTNTLLQGYSGVRWDILETVEKLLNAWLTPKLPLRGTITASGDLVPLSYIAGLLTGRPNSRVRSRDGIEMSGAEALKKVGLEKPFELQPKEGLAIVNGTSVGAALASIVCFDANVLALLSEVISAMFCEVMNGKPEFTDPLTHKLKHHPGQMEAAAIMEYVLDGSSYMKHAAKLHEMNPLQKPKQDRYGLRTSPQWLGPQVEIIRSATHMIEREINSVNDNPVIDVARDKALHGGNFQGTPIGVSMDNLRLSISAIGKLMFAQFSELVNDYYNGGLPSNLSGGPNPSLDYGLKGAEIAMASYTSELLYLANPVTSHVQSAEQHNQDVNSLGLVSARKSAEAIDILKLMLSTYLTALCQAVDLRHLEENMLATVKQIVSQVAKKTLSTGLNGELLPGRFCEKDLLQVVDNEHVFSYIDDPCNASYPLTQKLRNILVEHAFKNAEGEKDPNTSIFNKIPVFEAELKAQLEPQVSLARESYDKGTSPLPDRIQECRSYPLYEFVRNQLGTKLLSGTRTISPGEVIEVVYDAISEDKVIVPLFKCLDGWKGTLAHSEINNLPRSPLYNDCYDLSPRMLLLMLLFSDPEFDWS
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRP8_RHOPR
Sequence: QERRAMGFVGMR
What is the function of this protein?
Myoactive peptide.  Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
What are the official names of this protein?
Tachykinin-related peptide 8, Rhopr-TRP-8.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4B_CLOP1
Sequence: MAKMMGPRFKMCRRLGLNVVGHPKAMKRADRGTSRADKKLSDYGIQLLEKQRLRAYYGVMERQFTRYVDQAFNSKEQPGEALLMILESRLDNMVYRMGFASSIRQARQMVNHGHFLVNGKKVNIPSFRLNIGDEVVLREKSRKTEMFVNNFKDSIGSEVPYVSKEEDNFKGIFTRKPKREEIPITIQEQLIVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: QPCT_HUMAN
Sequence: MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
What is the function of this protein?
Responsible for the biosynthesis of pyroglutamyl peptides.  Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.  Also catalyzes N-terminal pyroglutamate formation.  In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta.  May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
What are the official names of this protein?
Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC, sQC, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, EC.
What is the protein family that this protein belongs to?
Belongs to the glutaminyl-peptide cyclotransferase family.
What are the subcellular locations of this protein?
Secreted.
Protein: CERL1_ARATH
Sequence: MASRPGALTEWPWSPLGSFKYLLVAPLVMASMHSYVTAVDEEKDLSRLMIVVLMLWRIVHSQIWISVSRQRTAKGTNKIVDKPIEFEQVDRERTWDDQVIFNTLLMYLANIKLPGASHLPPWRLDGAILMALLHAGPVEFLYYWFHRALHHHFLYSRYHSHHHSSIVTEPITSVVHPFAEHIAYTLLFAIPMVTASLCGILSIVSIMGYITYIDFMNNMGHCNFELFPKRLFHLFPPLKFLCYTPSFHSLHHTQFRTNYSLFMPIYDFIYGTTDNLTDSLYERSLEIEEESPDVIHLTHLTTHNSIYQMRLGFPSLSSCPLWSRPPWYLTCFMWPFTLLCSFALTSAIPLRTFVFERNRLRDLTVHSHLLPKFSFHYKSQRHHESINTIIEEAILEADEKGVKVMSLGLMNNREELNGSGEMYVQKYPKLKIRLVDGSSMAATVVINNIPKEATEIVFRGNLTKVASAVVFALCQKGVKVVVLREEEHSKLIKSGVDKNLVLSTSNSYYSPKVWLVGDGIENEEQMKAKEGTLFVPFSHFPPNKLRKDCFYQSTPAMRVPKSAQNIDSCENWLGRRVMSAWKIGGIVHALEGWEEHDCGNTCNVLRLHAIWEAALRHDFQPLPPSPL
What are the official names of this protein?
Protein CER1-like 1.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PBPA_RICPR
Sequence: MYKSLFLCLKIFAVLILIGCSVTAYIIYHYSHDLPDYSQLARYYPPSVTRIYSRDGKLIEEYAFERRVFVPINNVPSSLIESFIAAEDKNFYTHPGIDLLGIVRAAFLNISNYLHNRRMEGASTITQQVVKNFLLTNEVSLERKIKEVIISYMISRIFTKHQILELYLNQTFFGRGAYGVAAAAQNYFNKSVEELTIAESAFIAALPKAPSELNPDKNYSRVKARRDYVIERMFEDGYITRDTMKEAIGSPIVLRKRAKEETVTADYYAEQVREEVIRMLNSKEEFYRGGLTIITSLDAKMQQLAENSLRKGLREFDRKSGFRKPIANIPLDNWQEELKKLPTPSSLLEYKLAVVLDVSDNHAKIGLIDGSKAKIPIVEMQWARSNLKSVKTLLKKGDVIVVEPIKDCYALRQIPEVNGAIMVMNPHTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGVKPNQIFNDGPIEIIQGPGMPSWCPKNYEGQFLGDMTMRTGFEKSRNLITVRVATAVGLTKIVDIIKRFGINNEPKKVYSMVLGSIETTLSRITNAYAIIANGGKKVEPHFVELIQDRNGKIIYRRDNRECFSCNIADSDLDTAILEIPKEDIYRVTDEASNYQITSFLTGAIDSGTGYAARKLGKIIAGKTGTSNDSKDTWFIGFTPKIVVGSYVGYDTPKELGKKATGSNVVLPIFIDFMNHAYKDEPSLPFKVPDSIKLIAVDRITGKMIPNGTVIEAFKVNNIQMLENDYMIDNHDIFDYVPGMLDQSQEIY
What is the function of this protein?
Cell wall formation.  Synthesis of cross-linked peptidoglycan from the lipid intermediates.  The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
What are the official names of this protein?
Penicillin-binding protein 1A, PBP-1a, PBP1a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: SIR5_MONDO
Sequence: MSLLHFATRRLILQVLRELGLKAPPVHKTLKICIAMSRPSSNMADFRRFFARAKHIAIITGAGVSAESGVPTFRGPGGFWRKWKAEDLATPEAFAQNPSLVWEFYHYRREVILKKHPNAAHVAIAACEERLSLQGRRVVVITQNIDEFHTKAGTKNILELHGSLFKTRCCSCGNVRVNYNNPICPALEGKGLPDPNAPDAQIPLENLPRWKTTGDFSVLFLLDASPLYPSNLSCSHPVGAPALSEVADLGRWVGTSSLVYPAGMFGPHVALRGIPVAEFNTVTTPVTQNFRFHFSGLCGTTIPEALSPHESEKTG
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins.  Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting.  Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species.  Activates SHMT2 by mediating its desuccinylation.  Modulates ketogenesis through the desuccinylation and activation of HMGCS2.  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.  Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
What are the official names of this protein?
NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, SIR2-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
Protein: EF2_HALMA
Sequence: MGRRKKIVQECETLMDDPEHIRNIAIAAHVDHGKTTLTDNLLAGAGMISDDTAGEQLAMDTEEDEQERGITIDAANVSMTHEYEDQNHLINLIDTPGHVDFGGDVTRAMRAVDGALVVVDAVEGAMPQTETVLRQALREGVKPTLFINKVDRLISELQEGPEEMQKRLLAVIQDVNDLIRGMTEEMDDIEDWTVSVEEGTVGFGSALYKWGVSMPSMQRTGMDFGEIMELERADNRQELHERTPLSDVVLDMVCEHFPNPVDAQPMRVPRIWRGDAESQLADDMRLVNEDGEVVLMVTDIGVDPHAGEIAAGRVFSGTLEKGQELYVSGTAGKNRIQSVGIYMGGEREEVDRVPAGNIAAVTGLKDAIAGSTVSSEEMTPFESIEHISEPVITKSVEAQNMDDLPKLIETLQQVAKEDPTIQVEINEDTGEHLISGQGELHLEVIGQRIERNQGIPINTGEPIVVYREAPQEDSREVEGRSPNNHNRFYISIEPLGEDIVETIKMGEASMDMPELERREALQEAGMDKDDSQNIEHIHGTNILLDETKGIQHLNETMELVIEGLEEALDDGPLASEPVQGSLIRLHDARLHEDAIHRGPAQVIPAVREAVHNSLIDASIKLLEPIQQVRIDVPNDHMGAASGEIQGRRGRVDDMYQEGDLMVVEGVAPVDEMIGFSSDIRSATEGRASWNTENAGFQVLADNLQPDKISEIRERKGMKQELNPAIDYF
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.