PharMolix/UniProtQA huggingface dataset:
Protein: DEF_LACLA
Sequence: MISMDDIIREGYPTLREVANDVTLPLSDEDIILGEKMLQFLHNSQDPVMAEKMGLRGGVGLAANQLGLLKKVIAVLIPNEPEVDEDGNEIPPKEAYKMREIMYNAKVVSHSVQDAAVEGGEGCLSVDREVPGYVVRHARVTVEYYNKEGEKKKIRLKDFPAICVQHEIDHTNGVMFYDHINMNDPWEIKDGMIIVK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RS8_PROMM
Sequence: MANHDPISDMLTRIRNASEKRHQTTRVPASRMSRSIAKVLQQEGFISEISEEGEGVRTHLVLELKYSGKHRHPTIRSMQRVSKPGLRIYKNTRALPKVLGGLGMAIISTSKGVMSDRDARKQGVGGEVLCYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TI232_ARATH
Sequence: MAANNRSDHGSDENTRLYNPYQNYEVPINKSQYLYKLPTSPEFLFTEEALRQRRSWGENLTFYTGTAYLGGSVAGASVGVITGVKSFESGDTTKLKINRILNSSGQTGRTWGNRIGIIGLVYAGIESGIVAATDRDDVWTSVVAGLGTGAVCRAARGVRSAAVAGALGGLAAGAVVAGKQIVKRYVPI
What is the function of this protein?
Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.  Links the inner and outer membranes (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM23-2.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MBTK_MYCSS
Sequence: MQHRDVGKPTLSYSGRLIAQMTEIDEALKPVLPRELTTVSDEVRAVPAPPLPVLAEPFALRPADPDADAEMISEWMNRPHLVEAWEYPWPPQRWRRHLKAQIDGEYSRPLIGSFKGADVVYVELYRAAKDSIAPRYAADPHDIGIHAAIADLRFVNRGFAPLLLPRVVASVFEIDPRCRRIMFDPDHRNTGARRVCEFAGCTFLGEHDMANRRMALYALPRTPADAPPTGDLQSSPVGESISSS
What is the function of this protein?
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
What are the official names of this protein?
Lysine N-acyltransferase MbtK, N-acyltransferase MbtK, Mycobactin synthase protein K.
What is the protein family that this protein belongs to?
Belongs to the lysine N-acyltransferase MbtK family.
Protein: LEXA_NITHX
Sequence: MLTRKQYELLRFINERLKESGVPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLPNRARAIEVIKLPEVAGNGGGRRGFTPSVIEGNLGKVRPSGGGVVDDAERPVAVPVMGRIAAGTPIEALQTRSHTISVPPDMLGSGEHYALEVRGDSMVEAGILDGDMALIQRNETAETGDIVVALIDDEEATLKRFRRRGASIALEPANTAYEVRILPPNRVQIQGKLIGIYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GDN_HUMAN
Sequence: MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
What is the function of this protein?
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase.  Promotes neurite extension by inhibiting thrombin.  Binds heparin.
What are the official names of this protein?
Glia-derived nexin, GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Protease nexin I, Serpin E2.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RL29_STRZJ
Sequence: MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQLEQTARLKEVKKQIARIKTVQSEAK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: DOTC_DOTSE
Sequence: MSEDHTKADNLSEKDPHSPERSDSSSHEDAHAREEEESSDDDGALDGKPASLIAIVMIALSLIGLQLAVFLSALDTTIVTVALPAISAHFNSTAAYTWVGSAYLLANAASTPIWGKLADIFGRKPMLLLANALFMIGSLVCALSINVGMLITARAIQGAAGGGLLTLVDTIIGDLFSLRTRGTYLGMIGGVWAIACALGPIVGGAFTSSVTWRWCFYINLPIDGLAFGIIFFFLKLKTPKTPILEGFAAIDWAGSFFIIGGTLMFLFGLQYGGITFPWDSATVICLLVFGVVCIVLFGLVEWKFARFPIIPLRLFQYRNNCGALLVAFFHSFVFTSAFYYLPLYFQAVKGATPILAGVYILPAVLSTGVSAAATGAFIGNTGNYLIPMYFGMSMMILGYGLLINFDAGSGWAKLIIYQLIAGIGNGPNFQAPLVALQTKIKQSDIATGTATFNFVRNIATAISVVAGQVLYQNQLKKMTSTLQQLGPAASLIAAGDAGANTQAINALPTPQRDLARSAIADALSPMWIMYTAFAAAGLFCILLVSKTELTTTHEVTEVGLEAQKKAEAERKAERQAKDLEKAQKS
What is the function of this protein?
Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963).  One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production (PubMed:22069539).
What are the official names of this protein?
Efflux pump dotC, Dothistromin biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: DPO4_ECOL5
Sequence: MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVTLLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKSDLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_HORSE
Sequence: MNPLIFTTILMTVLLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYNPRTMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKVFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLVYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKMPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFETKRITLLPPLIVMSSLLLPLTPMLSILD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NDRG4_HUMAN
Sequence: MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQACTHSESSEGLGQVNHTMEVSC
What is the function of this protein?
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity).  May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF.  May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
What are the official names of this protein?
Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RS16_ASHGO
Sequence: MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVQPEILRFKVYEPLLLVGLDKFANIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKFVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGRGARARFQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NRDR_BRASO
Sequence: MRCPSCNSLDTQVKDSRPTEDSSVIRRRRVCVTCNFRFTTFERVQLRELTVIKRNGRRVPFDRDKLMRSVQISLRKRSVDPERVEKMVSAIVRELESGGESEVSSEAIGEIVMEHLRDLDDVAYVRFASVYRNFREAKDFEAVLGELSAEDETPRLAPVRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CEP2_SHV21
Sequence: MDDFRNKLRNFLNNECLWVKNVACTSFTKVYCATTAVSPFFKPISPQGVPDKHYINVTLIILKPKKSHPYITVYINDLAVDCCSTEILQVKPVPCSHFSLIYFGPLIAPPHNVQIPANLSIKASKKSHLTKNQVIFTSKVIHPERLPDGYKSASLIGACAWYSEGAIFQHFLSTDYMSLCPAFKEFPSLSRILSLLTRCDDLSCVPCYGEKIHVNCQSGYTDSDCDGKSNSCPCITSCTALKKDIVPITGHRNLLSLLFDATIQHNITSIKFFSPQTPTTVNNVFCGVLDTGETVECTCEAWNLLMFSDFISRQMIYNCQIMKRFCLRSC
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid.  Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
What are the official names of this protein?
Cytoplasmic envelopment protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Protein: TBB3_MAIZE
Sequence: MREILHIQGGQCGNQIGAKFWEVICGEHGVDSTGCYSGVSPQQLERINVYYNEAGGGRYVPRAVLMDLEPGTMESIRAGPFGGIFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTNPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPVGLSMSSTFVGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVAEYQQYQDATAEEYDEEEQDGEEEHD
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-3 chain, Beta-3-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL30_RALPJ
Sequence: MSQKTVKVQLVRSLIGTREDHRATVRGLGLRRMNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: C3AR_CAVPO
Sequence: MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMRRTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPIWCQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFTLENHTICTYNFSPGSFDYLDYAYDRDAWGYGTPDPIVQLPGEMEHRSDPSSFQTQDGPWSVTTTLYSQTSQRPSEDSFHMDSAKLSGQGKYVDVVLPTNLCGLPMEENRTNTLHNAAFLSSDLDVSNATQKCLSTPEPPQDFWDDLSPFTHEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRMRRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPESRVGAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSTSFIQAKAFSEKHSLSTNV
What is the function of this protein?
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a.  This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
What are the official names of this protein?
C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NMD3_CHATD
Sequence: MDLDSPMGMAPMMGTARTGATILCCNCGVPIDGTSSAGALCYDCIKSTVDISQGIQREGTLHFCRDCERWLMPPSTWVAAAPESRELLSLCLKRLRNLGRVRIIDARFVWTEPHSRRIKVKITIQDQVSDGVLMQQSFEVVYVVAYQQCRECAKSYTANVWRAVVQVRQKVTHKRTFLLLEQLILKHQAHKDTINIKEEKDGVDFFFAQRNQAEAFVHFLKSVVPITLKDSRHLISQDTHTGDKQYKFTYSAEIIPICRDDLVALPLKLAKQIGNIPPLCLCYRIGTAVYLLDPNTLHTAELSSDVYWRQPFRPLADATSMVEFIVMDIEATGIRKGKWVLAEVTVARASDLGVNDNVYFTRTHLGHLLHPGDSVMGYMLTGTNFNSDTFDAIENSRQYGSTIPDVVLVKKHYPNRRRNRRRNWKLKRLPKDEGELLPKATDQARMDDEYEAFLRDVEEDEELRATLALYKNTRKTKKPQQDADAMSIAETEDDDDGPKISMDELLDDFEDLDIQDDQ
What is the function of this protein?
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal export protein NMD3.
What is the protein family that this protein belongs to?
Belongs to the NMD3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Protein: GEML5_ARATH
Sequence: MTGSQEDQPKIIIDQEQPKTLETEHQPEPSSSSPDQKKWGTHVMGAPAAPVAHPDNQQAAAWVAGDNQQTQYQPYVIYSPVEHPTTNNPLEPVIGMFHTWSRKAETVARNLWHNLKTGPSMSETAWGKVNLTAKAITKGGFESLFRQIFGTEPNETLKKTFACYLSTTTGPVAGTVYLSNARVAFCSDRPLYFTAPSGQESWSYYRVVVPLANVATVNPVVVKETPPEKYIQLTTVDGHDFWFMGFVNYEKATHHLLTSVSDFQTAHGSVSG
What are the official names of this protein?
GEM-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the GEM family.
Protein: COMB_PSELT
Sequence: MIDVLFLPEPVSQQHVCVVVDVLRATSTIVTALANGARCVVPVRKIAEAKKRKAENILICGERKGIKPKGFDLGNSPIEYFTVKDKEVILTTTNGTRAISMINSQKLYAACFLNLHAVIEQLRNHDHVTIVCSGQKGKIAYEDVLCAGAIVYELNDKLTDGARISRELWKQSRRKDLSKLLFESQHAQELAEYGFSSDITFCSQTDLYSIVPVFVEDRFIKQAP
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: 3L273_DRYCN
Sequence: MKTLLLTLVVVTIVCLDLGDSLICYQAYNTPQTCAPGENLCYTKTWCDYWCHVKGKRIDLGCAATCPTAKPGEDVTCCSRDKCNPHPLQRPR
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 73, LNTX-73.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DTD_STRAW
Sequence: MRAVVQRVDGASVVVEGENGPETVGEINGEGLCVLVGVTHDDTEEKAAQLARKLWSVRMLADEKSCSDIDAPLLVISQFTLYGDARKGRRPTWNAAAPGDVAEPLVDEVVARLRALGATVATGRFGAQMRVSLTNDGPFTVLIEN
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERN1_HUMAN
Sequence: MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
What is the function of this protein?
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:21317875, PubMed:28128204, PubMed:9637683, PubMed:30118681).  In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875).  Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875).  The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875).  The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875).  Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).
What are the official names of this protein?
Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: EVI2A_HUMAN
Sequence: MPTDMEHTGHYLHLAFLMTTVFSLSPGTKANYTRLWANSTSSWDSVIQNKTGRNQNENINTNPITPEVDYKGNSTNMPETSHIVALTSKSEQELYIPSVVSNSPSTVQSIENTSKSHGEIFKKDVCAENNNNMAMLICLIIIAVLFLICTFLFLSTVVLANKVSSLRRSKQVGKRQPRSNGDFLASGLWPAESDTWKRTKQLTGPNLVMQSTGVLTATRERKDEEGTEKLTNKQIG
What is the function of this protein?
May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
What are the official names of this protein?
Protein EVI2A, Ecotropic viral integration site 2A protein homolog, EVI-2A.
What is the protein family that this protein belongs to?
Belongs to the EVI2A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SEM3C_HUMAN
Sequence: MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWASSVRALPFHPKDIMGAFSHSEMQMINQYCKDTRQQHQQGDESQKMRGDYGKLKALINSRKSRNRRNQLPES
What is the function of this protein?
Binds to plexin family members and plays an important role in the regulation of developmental processes.  Required for normal cardiovascular development during embryogenesis.  Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).
What are the official names of this protein?
Semaphorin-3C, Semaphorin-E, Sema E.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: XERC_XYLF2
Sequence: MSRLVEDFFAFLHVERGMSSHTLDAYRRDIGALIAWGGQQAVGEVVALDRAQLQAFVSAEHRRGLSAKSLQRRLSACRGFYTWLVKRGHIAVNPAAGLRAPKALRKLPRILDADEAVSFVQIPTDTPLGLRDRALLELFYSSGLRLSELCGLRWDGLDLDAGLVSVLGKGSRQRVVPVGSYALSALREWCASSGGGAQQPVFPGRYGGPISARAVQVRIKQLAQRQGMAKHVHPHMLRHSFASHLLESSGDLRGVQELLGHADITTTQIYTHLDFQYLSKVYDAAHPRARRKAR
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMI_STRP1
Sequence: MQVQKSFKDKKTSGTLYLVPTPIGNLQDMTFRAVATLKEVDFICAEDTRNTGLLLKHFDIATKQISFHEHNAYEKIPDLIDLLISGRSLAQVSDAGMPSISDPGHDLVKAAIDSDIAVVALPGASAGITALIASGLAPQPHVFYGFLPRKAGQQKAFFEDKHHYPETQMFYESPYRIKDTLTNMLACYGDRQVVLVRELTKLFEEYQRGSISEILSYLEETPLKGECLLIVAGAQADSEVELTADVDLVSLVQKEIQAGAKPNQAIKTIAKAYQVNRQELYQQFHDL
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD003_HUMAN
Sequence: MEVDAPGVDGRDGLRERRGFSEGGRQNFDVRPQSGANGLPKHSYWLDLWLFILFDVVVFLFVYFLP
What are the official names of this protein?
Uncharacterized protein C4orf3, Hepatitis C virus F protein-transactivated protein 1, HCV F-transactivated protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.