PharMolix/UniProtQA huggingface dataset:
Protein: Y037_MYCTO
Sequence: MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQFGDGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLVGANTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVVTMNSVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGPRVLGPDDTERAIHGSAVYAVVTGLLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLILLLVRHVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAATIQVAAAGLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVSYILSITVAAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR
What are the official names of this protein?
Uncharacterized MFS-type transporter MT0042.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YI105_YEAST
Sequence: MKTWMYSYLFDCPILVLPWTPHNYYLYHRFHHFLPLCYWHYSADTY
What are the official names of this protein?
Uncharacterized protein YIL105W-A.
Protein: GLDH_FLAJ1
Sequence: MRIKNSGILLLAAILLFSCDKKRVFDEYKSVGSAWHKDSVVTFDLPVLDSTKKYNLFVNLRDNNNYPFNNLFLIVAIETPSGFTKVDTLEYQMANPDGTLMGNGFTDIKESKLYYKEDVKFKGKYKVHIKQAVRESGKIPGVEALEGITDVGFRIEQKD
What is the function of this protein?
Required for gliding motility and chitin utilization.
What are the official names of this protein?
Gliding motility lipoprotein GldH.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: AROQ_ALKEH
Sequence: MPELLLLNGPNLNLLGTREPGIYGSDTLADIERRLGEQCAGAGVRFSAFQTNAEHALIDRIHQAGRAGVDFILINPGAWTHTSIALRDALLGVGIPFIEIHISNVHAREPFRRQSYLADVAVGVISGLGVHGYELALQAALKRLDGSPRGQH
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL19_CLOTE
Sequence: MLDVIKAIEAEQIRTDLPAFKVGDTVKVHVKIKEGTRERIQVFEGTVIKRQNGGLRETFTVRRLAYGVGVERTFPVNAPTVSKIEIVRKGKVRRAKLFYLRDRVGKAAKVKERRY
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SYP_LACDA
Sequence: MRQSIFFMPTLKETPADAVAKSHQVMLRGGYIRQVTAGVYSYLPLGYKVLRKTEKIIEEEMANAGVVEMIMPHMLPASMWEESGRLPKYGPEMFRLKDRHGREMLLGPTHEETFTDVVAKSLKSYKQMPLQLYQIQTKFRDENRPRFGLLRGREFVMLDGYSFAASQEQLDKQFDDEKAAYLKIFKRTGVEVRPVIADSGTMGGKNSIEFQAPAAVGEDTIATNASGTYAANLEMAVSVDTFKQEPEELKAMEKVATPGCDSIDKLAEFLQVPATRIVKSVLYIVDEKKKVLVLIRADKEVNEVKLTHLLDCDSLRVAETSDLEELTGAGKGGVGPVNADWADEIVADKTVKGLYNVVVGAGESDAQFINANLDRDFRADRFADLRVANEGEPDPVDHEPLKFTTSIEVGHIFKLGTYYTETMGAKFLDQNGKSQPVIMGSYGIGVTRLLSAVVEQHATENGVAWPKEIAPFGIHIIQMKMKDEIQSKLAEDLEAKFAKYDVLYDDRNERPGVKFNDADLVGAPIRITVGRDAADGIVEVKRPGDDQAQKLAVADLEDFIANELD
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYH6_RABIT
Sequence: ILERGDALLVVQWNIRAFTGVKKWPWMELYFEIEPLLKSAEAEKEMAAMKEEFGRIKESLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKLKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLEERLKKKEFDISQLNSKIEDEQALVLQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATASALRRKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRRKLEEAQR
What is the function of this protein?
Muscle contraction.
What are the official names of this protein?
Myosin-6, Alpha isomyosin, Myosin heavy chain 6, Myosin heavy chain, cardiac muscle alpha isoform, MyHC-alpha.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Protein: KNAT7_ARATH
Sequence: MQEAALGMMGATVGGDGDTAVVAEQNRQLKGEIATHPMYEQLLAAHVACLRVATPIDQLPIIEAQLSQSHHLLRSYASTAVGYHHDRHELDNFLAQYVMVLCSFKEQLQQHVRVHAVEAVMACREIENNLHSLTGATLGEGSGATMSEDEDDLPMDFSSDNSGVDFSGGHDMTGFGPLLPTESERSLMERVRQELKLELKQGFKSRIEDVREEIMRKRRAGKLPGDTTTVLKNWWQQHCKWPYPTEDDKAKLVEETGLQLKQINNWFINQRKRNWHNNSHSLTSLKSKRKH
What is the function of this protein?
May be involved in secondary cell wall biosynthesis.
What are the official names of this protein?
Homeobox protein knotted-1-like 7, Protein IRREGULAR XYLEM 11, Protein KNAT7.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDUA1_VARRB
Sequence: MWFEILPGIAVMGTCLVIPGLATAYIHRFTNGGKEKRVAHFVYHWDLMERDRHISGVNRYYVSKGLENID
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, Complex I-MWFE, CI-MWFE, NADH-ubiquinone oxidoreductase MWFE subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA1 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: ORYZ_ASPFC
Sequence: MLSIKRTLLLLGAVLPAVFGAPVQETRRAAQKIPGKYIVTFKPGTDTATIESHTLWATDLHKRNLERRDTTSGEPPVGIEKSYKIKDFAAYAGSFDDATIEEIRKSADVAHVEEDQIWYLDALTTQKGAPWGLGSISHKGQASTDYIYDTSAGAGTYAYVVDSGINVNHVEFESRASLAYNAAGGSHVDSIGHGTHVAGTIGGKTYGVAKKTNLLSVKVFQGESSSTSIILDGFNWAVNDIVSKGRTKKAAINMSLGGGYSYAFNNAVENAFDEGVLSVVAAGNENSDASNTSPASAPNALTVAAINKSNARASFSNYGSVVDIFAPGQDILSAWIGSTTATNTISGTSMATPHIVGLSVYLMGLENLSGPAAVTARIKELATNGVVTNVKGSPNKLAYNGNA
What is the function of this protein?
Secreted alkaline protease that allows assimilation of proteinaceous substrates (By similarity).  Acts as a significant virulence factor in invasive aspergillosis.  Involved in immune evasion from the human and mice complement systems during infection.  Efficiently cleaves important components of the complement cascade such as such as C3, C4, C5, and C1q, as well as IgG, which leads to down-regulation of complement activation at the hyphal surface (By similarity).
What are the official names of this protein?
Alkaline protease 1, ALP, Aspergillopeptidase B, Aspergillus proteinase B, Elastase, Elastinolytic serine proteinase, Oryzin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: F16PA_HELPJ
Sequence: MDYKRFKGKHANIVIEIISLLEKGVKKAQEILEKPDAGSYTQLENSSGDTPIKADLALDKFLEETFLSLENVKSVFSEEKETPVTKENGSYLIAYDPLDGSSVMEANFLVGTIIGVYEKDYKAQNLVASLYVVFGHKIELVVALEEVYRYAFYQNKFHFIETIVLENKGKIIASGGNQKDFSLGLKKALEGFFAENYRLRYSGSMVADVHHVLVKKGGMFSYPQKKLRKLFEVFPLALMVEKAKGEAFYFDKGVKKRLLDQSVESYHEKSECYLASPHEAQILEKHLKGE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NMT_CRYNJ
Sequence: MDSSDSKAATDEEIRRALKAADLMKILDGKIALGNKSGTKNLGEHKFWKTQPVPQITGSGAPAPIEEGPIDDPKTPADVRQEPGVLPAGFEWSTIDINDEEQSKEVYVLLCENYVEDDDAMFRFNYSREFLLWALTAPGYLPDWHIGVRVQKTKKLVAFISGIKIDIRVRAKTFPAAEINFLCVHKKLRSKRLAPVLIKEVTRRVNLTNIWQAIYTAGVILPTPIGTCRYFHRNLNPPKLVDIGFSPLPRGSTIARLVQQYSVPSHPRIPGFREMKKEDVPQVGALLRRYLDRFDVAQAFRDDDEVEHWLLSGQGKEVGGRRVEQVVWAYVVEDPTTHRITDLISFYALPSTIMKHPKHNLLNAAYMFYYATDVVFPPSSSSANSDVDVDANAGESSVAAVGTGGEDAKTKKKLETRLNALTADILIIAKQAGFDVFNALTLLDNNMFLQEQKFGPGDGYLNYYLYNWNCAPIDGGHHSTTAKQGSKIGVVML
What is the function of this protein?
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
What are the official names of this protein?
Glycylpeptide N-tetradecanoyltransferase, Myristoyl-CoA:protein N-myristoyltransferase, NMT, Peptide N-myristoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_ECO81
Sequence: MKKFRWVALVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CDD_YERP3
Sequence: MQARFHTSWAELPASLQFALEPILSAENFPAMLTAEQVKTVKNISGLDDDALAFALLPLATACALTPISHFNVGAIARGKSGNFYFGANMEFRGVPLQQTIHAEQCAVTHAWLRGETNLVAITVNYTPCGHCRQFMNELNSGSELHIHLPGRPPSTLGQYLPDSFGPTDLAITTLLMDPVNHGYTLAETDPLTQAALNAANHSHAPYSQSHSGVALETTNGKIYAGRYAENAAFNPSLPPLQAALILANITGENCASIRRAVLVEGHNAVTSQWDTTLATLNALGCSAVKRVTF
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: LEU1_YEAST
Sequence: MVKESIIALAEHAASRASRVIPPVKLAYKNMLKDPSSKYKPFNAPKLSNRKWPDNRITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNYNDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATINNIIHSGDVSIPSLAEVEGKNAAASGSA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
What are the subcellular locations of this protein?
[Isoform Cytoplasmic]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.
Protein: RF1_HALHL
Sequence: MKATIRNKLERMAERHEEIGAQLADPDVVGDPSKFAELSREYARLEPVVQDLNAYRAEADTVASAEAMLNDGDAEIRALAEQELAEAQRRLEELEGALQRHLVPTDPNDQRNIFLEVRAGAGGDEAALFAGDLLRMYMRYAERQGWKTEILSAREGEHGGYREVIARVSGRSVYARLKFESGAHRVQRVPATESQGRIHTSACTVAILPELDEVSAIEVNTADLRVDTFRSSGAGGQHVNTTDSAIRITHLPSGLVVECQDERSQNKNRAKAIALLQARLTEQERAKQQSERSEQRRLAVGSGDRSERIRTYNFPQGRVTDHRIGLTLYKLEQVMEGGMDELLDGLTQEHQAEALAEIAEDSG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_MOOTA
Sequence: MPAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEVGIYSEVHRLPAATSQAELLKLIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVDGFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKKAVVVGRSNIVGKPVAMMLLARHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLVGDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ALX4_MOUSE
Sequence: MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRGFPGGDKFGTTFLSAGAKGQGFGDAKSRARYGAGQQDLAAPLESSSGARGSFNKFQPQPPTPQPPPAPPAPPAHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELPPDSEPVGMDNSYLSVKETGAKGPQDRASAEIPSPLEKTDSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVSDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNGYEMNGEPDRKTSSIAALRMKAKEHSAAISWAT
What is the function of this protein?
Transcription factor involved in skull and limb development.
What are the official names of this protein?
Homeobox protein aristaless-like 4, ALX-4.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COBS_ALKMQ
Sequence: MNIDMNRFISILQFLTRIPIKRDVPMEEAFHKGIIYFPVVGGIIGALLMVAYRGASLYLAHSLSALLTVGFFVFLTGGLHLDGLGDTFDGLYSNRNKETILEIMKDSRLGTNGVLAMVFILLLKLYGIQGLGEHQIYWGIILMPVMGRQAIVYGCYRTIYGRSQGLGHLFIGKVSKKELLISSLLTFILAAMHLPSLIFALLLPIGSQLYKGHVMKKIDGMTGDTLGSLCELTEGCYLLFILLITGAGLF
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1396_ARATH
Sequence: MATDDFFSLQREYWRQVAESDGFDIESVQIPPSMYGRINGLIPHNCEINTPLPYRVLGKHYAKLGLHRYNMLKGTKFEFGRLMKFNMLQNCVASFYITLEAYDYGVPGTSHPQTFQVRIDEKIFGSLDLTVSIARRTTDEVTTKKPFIHHYHGGAVADNIIFKGELPDWPSDDVLKDRERFYVIMNESEWRATAWISLYLELVLCAHDKFITNTDLSRLSIEKVAIETSIGDALLYERLEAKSANVYIWFKRLEKPRVPQQVFVTGMDVERKAIIRRVMDSTGYLTLVGKLCGGVTKVRQFN
What are the official names of this protein?
UPF0725 protein At1g23960.
What is the protein family that this protein belongs to?
Belongs to the UPF0725 (EMB2204) family.
Protein: Y1455_THEAC
Sequence: MSGIVTYGSYIPRYRIKPDEIARVWGENPDHIKNGIYILSKSVPAPDEDVATISVEAARNALKRKKIDPKEIGAIYVGSESHPYAVKPTATIVGSAIGVDFSLFAADYEFACKAGTAGMQNVKAMVDSGMIKYGLAIGADTSQGAPGDALEYSASAGGTAFIIGKDDTIAEINSTLSVASDTPDFWRREGQPYPSHGERFTGEPAYFRHVITAAKMMMERMETQPKDYDYVVFHQPNGKFPTRAAKMLGFEEKQYKDGLLTPYIGNTYSGSMMTGLSSILDVSKPGDHILAVSFGSGAGSDAFDITVTDRIEEMDRNRAPTIKKMLENVKWVDYAIYAKYKKKIIVGDGIE
What are the official names of this protein?
UPF0219 protein Ta1455.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. UPF0219 family.
Protein: EGTD_MYCTO
Sequence: MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK
What is the function of this protein?
Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine (ERG).  ERG is one of the major redox buffers which protects bacteria against redox stressors and antibiotics; loss of ERG or mycothiol (MSH, the other major redox buffer in this bacteria) leads to respiratory alterations and bioenergetic deficiencies that negatively impact virulence (PubMed:26774486).
What are the official names of this protein?
Histidine N-alpha-methyltransferase, Histidine trimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. EgtD family.
Protein: CCSA_PROMM
Sequence: MFGVTLAELSASLGDPVLALGLAAFALLLLAIPISFWMVSGGSNSAVVTLLVALANLVLTAQLVLRWWQSGHFPISNLYESLCFLAWACTLAQLLVERSLSSPIVSAAATPMALLCVAFASFALPETLQEASPLVPALRSSWLVMHVSVIMCSYAALLVGSFLSMAVLFTDRQQTLELRSSSIGTGGFRQAKLATSSMDQSDGLRLSSINLSRTEQLDSLSYRTITVGFLLLTLGLISGAVWANEAWGSWWSWDPKETWALICWMVYAAYLHTRFSRGWSGRRPALVAVAGIVVIVVCYIGVNLLGIGLHSYGWFFEA
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RLUA_HAEIN
Sequence: MALIEYNPPLEPYLDIIYQDNHLCVVNKPSGLLSVPGNQPQYYDSAMSRVKEKFGFCEPAHRLDMATSGIIVFALSKAADRELKRQFREREPKKHYQAIVWGHLENDYGEVNLPMICDWENRPRQRLDFVLGKRAVTKFEVLARLPNNSTRVKLTPVTGRSHQLRLHMLALGHPILGDKFYSHPQAKVMSPRLCLHAEELTITHPITGETMTFNAKSDF
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluA, 23S rRNA pseudouridine(746) synthase, Ribosomal large subunit pseudouridine synthase A, rRNA pseudouridylate synthase A, rRNA-uridine isomerase A, tRNA pseudouridine(32) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: Y1399_YERPE
Sequence: MDHRLLEIVACPVCNGKLYFNKENLELVCKVDNLAYPVRDGIPVLLENEARPLSIDEKHA
What are the official names of this protein?
UPF0434 protein YPO1399/y2773.1/YP_1194.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: NAGS_ASHGO
Sequence: MLFRRLLTTKVGYHTPNYVNRRLILSVLKSTATRREAKDYLTKYGDPAVAYHCVLYLRGTKTFSAGLINDFAIMLGRLRLLGIRPLVVLSPSKHVMTESEILRETFYKHGLQSIPINEPMASGTRETILQNGASYNSIIPIIMPFVYHQQRAKRMLAEDEVAFMRELVAYMPCRIDKFFIINRYGGIPSSERHDNSHVFVNLSQEYGSLAEVLKQQITDLRHEMDDGLLAERRATDGSYKEFQYTTLTESLTDLELMSAVLSLLLPSSTGLITSMHSAVTNSRYNPLLYNVLTDRSLVSSSLPSFKRDPISDNAWYELPACGAKIGTQRANPIFSTTVLKQGVDIKLYDYSTLTKENSVGFHELLSTAGSAQLPAHKRVNLTKLKGIIEHSFDRNLDMSHYLKRINGKIASIIVIGDYEGIAILTYEGPEKRPFAYLDKFAVLPHLRGSLCISDVIFNLMFKKFGDELVWRSRRENVVNNWYFQRSVGVLDLSIDIGHGPKKDNIFKLFYYGGKKGTQFYDFDRLREYITYVRDIEPSWSRK
What is the function of this protein?
N-acetylglutamate synthase involved in arginine biosynthesis.
What are the official names of this protein?
Amino-acid acetyltransferase, mitochondrial, Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RPOB_BREBN
Sequence: MAGKVIQSGRHRQRRTYSRINEVLGLPNLIEIQQKSYQWFLDEGLREMFQDISPIQDFTGNLVLEFIDYSLGEPKYDVDESKERDVTYAAPLRVKVRLLNKETGEVKEQEVFMGDFPLMTETGTFIINGAERVIVSQLVRSPSVYYNTKVDKNGKQTFTATVIPNRGAWLELETDAKDVIYVRIDRTRKIPVTVLLRALGFGSDIEILNLLGEDEYIKNTLEKDNTDSTEKALIEIYERLRPGEPPTVENAKSLLISRFFDPKRYDLASVGRYKMNKKLHLKNRLYNQRLAETLIDTTTGEIFAEAGQMIDRRVLERIVPALEGSIGFIDVRTHGGVLEDEAIHLQSINIFSPIEDGKIIKVIGNGNVDKSFKHITPADIVSAINYFMNLLHSVGSTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDQNQITPQALINIRPVIASLKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSSFARINDYGFIETPRRKVDPETGFVLTDISYLTADEEDVFNVAQANQPLDEDGRFVNDMVICRRKGEILSVPRDKVDFMDVSPKQVVSVATALIPFLENDDANRALMGSNMQRQAVPLLIPQAPFVGTGMEHKAAQDSGVAIVAKHPGQVERVTAREIWIRRYQEIDGRKVAGDLDKYKMHKFIRSNQGTCINQRPIVSTGDWIEKGDIVGDGPSTEKGELALGRNVIVAFMTWEGYNYEDAILLSEKLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRVGAEIQDGDILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGSGIIVDVKVFTRENGDELPPGVNQLVRVYIAQKRKISVGDKMAGRHGNKGVIARIMAEEDMPFLPDGSPVEIVLNPLGVPSRMNIGQVLETHLGMAAKLLGIHVATPVFDGARQAEVFETLAEAGLDRDGKTILFDGRTGEPFDRRVTVGCVYMLKLAHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTVKSDDVVGRVKTYEAIVKGENVPEPGVPESFKVLIKELQSLGMDVKILSGDEQEIEMREMEDEDEGNGEKLNLVLEGGSLNEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: BST1_MOUSE
Sequence: MAVQGGLLSLWLWLWLSLLTVLLGARARWRGEGTTPHLQSIFLGRCAEYTTLLSLGNKNCTAIWEAFKGVLDKDPCSVLPSDYDLFINLSRHPIPRDKSLFWENNHLLVMSYGENTRRLVALCDVLYGKVGDFLSWCRQENASGLDYQSCPTSEDCENNAVDSYWKSASMQYSRDSSGVINVMLNGSEPKGAYPTRGFFADFEIPYLQKDKVTRIEIWVMHDVGGPNVESCGEGSVKILEDRLEALGFQHSCINDYRPVKFLMCVDHSTHPDCIMNSASASMRRESASLHAIGDASLLISLLVALASSSQA
What is the function of this protein?
Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR).  Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium.  May be involved in pre-B-cell growth.
What are the official names of this protein?
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Antigen BP3, BP-3 alloantigen, Bone marrow stromal antigen 1, BST-1, Cyclic ADP-ribose hydrolase 2, cADPR hydrolase 2, Leukocyte antigen 65, Ly-65.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: FLAD_VIBCH
Sequence: MAVNVNTNVAAMTAQRYLTGATNAQQTSMERLSSGFKINSAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSANGSNSKSERVAIQEEITALNDELNRIAETTSFGGNKLLNGTFSTKSFQIGADNGEAVMLTLKDMRSDNRMMGGTSYVAAEGKDKDWKVQAGANDITFTLKDIDGNDQTITVNAKEGDDIEEVATYINGQTDMVKASVNEKGQLQIFAGNNKVTGDVAFSGGLAGALNMQAGTAETVDTIDVTSVGGAQQSVAVIDSALKYVDSHRAELGAFQNRFNHAISNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALSLLG
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  FlaD is not essential for flagellar synthesis and motility.
What are the official names of this protein?
Flagellin D.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.