PharMolix/UniProtQA huggingface dataset:
Protein: MOS_CHLAE
Sequence: MPSPLALRPYLPSEFSPSVDARPCSSPSELPAKLLLGATPPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYHGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAASHPEGDAGEPHCSTGGPLTLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPLYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFQDSLPGQRLGDVIRRCWRPSAAQRPSARPLLVDLTSLKAEFG
What are the official names of this protein?
Proto-oncogene serine/threonine-protein kinase mos, Oocyte maturation factor mos, Proto-oncogene c-Mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CITE4_MOUSE
Sequence: MADHLMLAEGYCLLQVPPHTHGPHAPRTLQPYAGPGMDSGLRPRGAPLGPPPPPGTLAYGSFGSPVSFQPFPVSQSPGAGSTHLQSAATPSPGRIPAPPAAAGGPSPLQPAPGAAASLPPPPPPPALGCMDTELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPAAGSVSC
What is the function of this protein?
Acts as transcriptional coactivator for TFAP2/AP-2.  Enhances estrogen-dependent transactivation mediated by estrogen receptors.  May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP.  May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
What are the official names of this protein?
Cbp/p300-interacting transactivator 4, MSG1-related protein 2, MRG-2.
What is the protein family that this protein belongs to?
Belongs to the CITED family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MNMC_PSYCK
Sequence: MPKPASMAMNTTKSTTPAHVISPANIEWQTDDAGNEVPVSGEFGDAYFSQADGLAESHHVFLAHNQLPTRLANLIPKQCFTIYELGFGTGLNLLATWQLWRQLRLTHPHLASARLHFITTEKHPVPFSDLAKILAPLGQRTPELALLIEQLLTSYPPLIAGCHRLDFIDDNLTLDIWLGDANDSLASLDSTVATQRPYINAWFLDGFAPSCNEILWTERIFSHMQRLSRAGTTAATYSCAGIIKRGLQSQGFVIKKSKVLGSKREMLTAVMSEMSSLDKPISTLSNKVTLSNYPNNAVVIGAGVAGLLTAWSLANRGISVTVLDKDAPLAGASGNPRALLAPNMTPIHHVYEHLHSIGYLYSGRLYRYFNQQAAIQKSPLILEQTGTLDLLVKTNIGTEQILDYPDTMATTISPEKAQDISGLKDKDLAHNLYMPQAGLVNPQALQTVILAHPNITYQQLNIINIKETENSIILTGSKEDENASQASLTITADHVVICAAYESHQLDKRIVKCRTIRGQLSWFTPTAQQLTQLPKLPLKYSGYCAPFIGQSGDAELNHISENQPQFLLGASFIDGDTNIDVRDEENQQNYDKLIEDMPELSSVLPNDISTWHARAGIRTQTMDYHPLVGLLAQSQRLWSMSAMGAKGYAIAPICAEALADMMLGCFTPLSAAMLARLSPNRARLHKVHKHKTRQAVI
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_RHOPS
Sequence: MRPVIIHTDGACSGNPGPGGWGAILKFGDTEKELKGGEAHTTNNRMELLAAISALEALTRPCTVDLYTDSQYVKNGIGSWIHNWKRNGWKTADKKPVKNVDLWQRLDAALKSHEVRWHWVKGHAGHDENERADQLARDGLTKHRLKSRIG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_LEPBL
Sequence: MILAAPTGAGKTSLVTELDPTRFEILSFDSRQIYKNMSIGTAAPTKKEQSKIAHHLVEVLSPSEAVDAGLYNRLAEEALQKVLNLDKIPVFTAGTGFYLKAFLFGMFPVPEIDVSVRDRVLSMSKEEKKNLLKELDPNALDKIFPEDDYRLGRALEVNLMGEKWSRLKIDPNTSAICRYDLDIRLGVFLDLDRKELYERINLRAKQMIEKGMADEAWKIQERFGETCPGLKSLGYNFALENKKGNSNLETFLADLSRSHRNYAKRQVTWFRKEPYVQPMGRSEALERIKHMK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TPC10_HUMAN
Sequence: MDASEEPLPPVIYTMENKPIVTCAGDQNLFTSVYPTLSQQLPREPMEWRRSYGRAPKMIHLESNFVQFKEELLPKEGNKALLTFPFLHIYWTECCDTEVYKATVKDDLTKWQNVLKAHSSVDWLIVIVENDAKKKNKTNILPRTSIVDKIRNDFCNKQSDRCVVLSDPLKDSSRTQESWNAFLTKLRTLLLMSFTKNLGKFEDDMRTLREKRTEPGWSFCEYFMVQEELAFVFEMLQQFEDALVQYDELDALFSQYVVNFGAGDGANWLTFFCQPVKSWNGLILRKPIDMEKRESIQRREATLLDLRSYLFSRQCTLLLFLQRPWEVAQRALELLHNCVQELKLLEVSVPPGALDCWVFLSCLEVLQRIEGCCDRAQIDSNIAHTVGLWSYATEKLKSLGYLCGLVSEKGPNSEDLNRTVDLLAGLGAERPETANTAQSPYKKLKEALSSVEAFEKHYLDLSHATIEMYTSIGRIRSAKFVGKDLAEFYMRKKAPQKAEIYLQGALKNYLAEGWALPITHTRKQLAECQKHLGQIENYLQTSSLLASDHHLTEEERKHFCQEILDFASQPSDSPGHKIVLPMHSFAQLRDLHFDPSNAVVHVGGVLCVEITMYSQMPVPVHVEQIVVNVHFSIEKNSYRKTAEWLTKHKTSNGIINFPPETAPFPVSQNSLPALELYEMFERSPSDNSLNTTGIICRNVHMLLRRQESSSSLEMPSGVALEEGAHVLRCSHVTLEPGANQITFRTQAKEPGTYTLRQLCASVGSVWFVLPHIYPIVQYDVYSQEPQLHVEPLADSLLAGIPQRVKFTVTTGHYTIKNGDSLQLSNAEAMLILCQAESRAVVYSNTREQSSEAALRIQSSDKVTSISLPVAPAYHVIEFELEVLSLPSAPALGGESDMLGMAEPHRKHKDKQRTGRCMVTTDHKVSIDCPWSIYSTVIALTFSVPFRTTHSLLSSGTRKYVQVCVQNLSELDFQLSDSYLVDTGDSTDLQLVPLNTQSQQPIYSKQSVFFVWELKWTEEPPPSLHCRFSVGFSPASEEQLSISLKPYTYEFKVENFFTLYNVKAEIFPPSGMEYCRTGSLCSLEVLITRLSDLLEVDKDEALTESDEHFSTKLMYEVVDNSSNWAVCGKSCGVISMPVAARATHRVHMEVMPLFAGYLPLPDVRLFKYLPHHSAHSSQLDADSWIENDSLSVDKHGDDQPDSSSLKSRGSVHSACSSEHKGLPMPRLQALPAGQVFNSSSGTQVLVIPSQDDHVLEVSVT
What is the function of this protein?
Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether.
What are the official names of this protein?
Trafficking protein particle complex subunit 10, Epilepsy holoprosencephaly candidate 1 protein, EHOC-1, Protein GT334, Trafficking protein particle complex subunit TMEM1, Transport protein particle subunit TMEM1, TRAPP subunit TMEM1.
What is the protein family that this protein belongs to?
Belongs to the TRAPPC10 family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network.
Protein: KDUI_SALPC
Sequence: MDVRQSIHSEHAKTLDTQALRREFLIENIFVADEYTMFYSHIDRIIVGGIMPVSHSVEIGGEVGKQLGVSRLLDRRELGVINIGGAGAIIVDGQRHDIGHRDALYIGKGAKELVFVSNEASRPAKFYYNCAPAHTAYPTKKVSPADVAPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYLYFNMEEDSCVFHMMGQPQETRHIVMRNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVQDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: RSXE_SALNS
Sequence: MSEIKDIVVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTVSALRRWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPWLSALDGFSIGMGATGAMFVLGSLREILGNGTLFDGADSLLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAVKYLIDEKMKKRRAETAPSAVPAGETGKV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OPGH_VIBC3
Sequence: MTNPMVEQGASQLMGGSAMPPEQHGEMPEQNLKRLSEGFPRDAIQTGGVKSCSWRRVFVVGFALLISAFAIFEMRGVFLVGGLTPIEYAVLVLFAINFCWIALAFSSSIAGFFVLASRKPAPNTEQPLTTRTAILMPTYNEAPDRVFAAVETMALALAKTEHGHAFDWFILSDTTDPEVALSEEQAFWLLRQQTAGKANVYYRRRRKNIARKAGNIADFCRRWGSGYDHLLVLDADSVMQPSTMISLAQRMQSDPDAGLIQTIPALINGTTLMARVQQFAARIYGPVVGTGLAWWVQKEGNFWGHNAIIRTEAFMSAAGLPHLSGRPPFGGHILSHDFVEAALIRRAGWSVTIAADLSGSFEECPPSIIDLAVRDRRWCQGNLQHSRIIGTKGLHWISRLHLTTGIMSYLSSPFWLLLILSGLLLALQAHFIRPEYFTEQFSLFPTWPVMDSARALQLFYITMGILFSPKIFGLLLLMFDGEMCRTLGGRLRVILSAVTEILLSALVAPIMMLIHCGAVVSILFGRDSGWAPQRRDDGSLPIKDLLYRHRWHMTAGVLLGYAAMLDSWTLLAWMSPALIGLWFSVPLSGITASYTIGAWFKQKRILATPEEIETPAIVLAAQARRDEYVVDLQEVWNARMVLADHNLIALHIAMMDKLPSRQPGTAIEPLDAVARIKVQEAESQESLLALLTKVELSYVLGNPLLIQQVAKLPPSLANQTV
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPA_GRAFK
Sequence: MNTDVAPVKSKTERKPKPKWLRVKLPTGKKYTELRNLVDKYDLHTICTSGSCPNMGECWSEGTATFMILGNVCTRSCGFCGVKTGRPETVDWDEPEKVARSIKLMQIKHAVVTSVDRDDLKDMGSIVWAETVKAIRRMNPETTLETLIPDFQGNERNIDRIIEVAPEVVSHNMETVKRLTREVRIQAKYDRSLAVLKYLKDNGIRRTKSGIMLGLGEQEEEVIQTLKDLREAGVDVVTIGQYLQPSKKHLPVKQFITPDQFQKYEKIGLELGFRHVESSALVRSSYKAQKHLN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAZA2_MOUSE
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: MPC1_YEAST
Sequence: MSQPVQRAAARSFLQKYINKETLKYIFTTHFWGPVSNFGIPIAAIYDLKKDPTLISGPMTFALVTYSGVFMKYALSVSPKNYLLFGCHLINETAQLAQGYRFLKYTYFTTDEEKKALDKEWKEKEKTGKQ
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 1, MPC1, Protein FMP37.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PBO5_CAEEL
Sequence: MTRLSILQHLLTFLILSKINATSTTESYFDSSEEAPNVLLNHLNNESEGEELTQINDTQPAFVPGSSKRLTEYLLSRHNLNAPPDGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDPALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSCEINIRHFPLDDQRCAIEIASWAYGQEKIRLHAHTDHSLEHYKRNEEWHLLNLNVSEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGVTAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGRYGDEPSDFWMRCFLLKPVFRTSNRRKYRMNPEEPTQVILVSEAKNGEVLTKKSTELNGTVVKEIMLSSRLEALEEYIRKMVNRCETIKWELDEIDAAENIELVRRRSTNGYVRISERLDILFMFLFLSTVTIPVAVLFYLT
What is the function of this protein?
Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle (PubMed:18191228).  Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells (PubMed:25849533).  Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline (PubMed:18191228).
What are the official names of this protein?
Proton-gated ion channel subunit pbo-5, PBoc defective protein pbo-5.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: NXPE3_BOVIN
Sequence: MWINFVKLRLFCCLLAVLMVVVLVVNVTQVEYLDRETASATFIDSGGQFVSSQVIRISRNPYCGYERQILSSRERLEEDSLLAALQWQEPDVGPVPFLKSTDPSSSYFVILNSAAFFRVGSQLEVLVHVQDFQRKPKKYGGDYLQARIHSPKLQAGAVGRVVDYQNGFYKVFFTLLWPGQVKVSISLVHPSEGIRVLQYLQEKKPDRVYFKSLFRSGRISETTECNVCLPGSLPLCNFTDLYTGEPWFCFKPKKLPCSSRINHFKGGYLKGLLTATENAFFQSGVNIKMPINSSGPDWVTVIPRNIKETNSLELSQGLGTFPSGYYYKDQWRPRRFKMRQFNDPDNITECLQRKVVYLFGDSTIRQWFEYLTTFVPDLVEFNLGSPKNVGPFLAVDQKHNILLKYRCHGPPIRFTTVFSSDLRYVANELNGIVGGKNTVVAIAVWSHFSTFPLEVYIRRLRNIRRAVVQLLDRSPKTVVVIRTANVQELGPEISLFNSDWYNFQLDTILRKMFSGVGVYLVDAWEMTLAHYLPHKLHPDEVIVKNQVDMFLSFVCPLET
What are the official names of this protein?
NXPE family member 3, Protein FAM55C.
What is the protein family that this protein belongs to?
Belongs to the NXPE family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYA_GRABC
Sequence: MATSNDIRATFLNYFARNGHEVVDSSPLVPRNDPTLLFVNSGMVQFKNVFTGQERRPYSRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEQAITHAWNVVTREFGLPAEKLLVTVYQDDDDAARLWKSIAGLPEERIIRIASSDNFWRMGDTGPCGPCSEIFYDHGPSIPGGPPGSPDEDGDRFIEIWNLVFMQYEEGPPGTRVNLPRPSIDTGMGLERLAAVLQGKHDNYDTDTLRALIVASAEATGQDPDGPHKTSHRVVADHLRSTSFLMADGVLPSNEGRGYVLRRIMRRAMRHAHLMGMTEPLLYRLVPALVRQMGAAYGELVQAQSLITETLRLEETRFKAMLDRGLAMLSDEVGKLGEGQTLSGDVAFKLYDTYGFPLDLTQDALREQGRAVDVAGFDAAMTEQRRRARAAWSGSGDAAQEGVWFEIRDRVGGTEFLGYSTEKAEAEIIALVANGALTETAPAGTEVAVVLNQTPFYGESGGQVGDTGIITGPNGLRIIISDTQKKLGDVFVHLGRVESGLAQIGQPVEVVVDHQRRSAIRAHHSATHLLHEALRRRLGTHVAQKGSLNAPDRLRFDVSQPTPITRDDLAVVEAEVNALIRQNSPVNTRLMTPEQAVAEGAMALFGEKYGDEVRVVSMGAPVEEGKPAYSIELCGGTHVGRTGDIGLFRITGESAVSAGVRRIEAVTGEAALAQIAEAERRLQETASLLRVAPGDVTTRVASLLEERKKLEAQLADAQRKLATGGAADKVEEVGGVKLAARNLGDVAPKELKGLAEAIARQLESGVVALVSTAEGKASVVVGVTADLTSRFDAVTLVRAASAAVGGKGGGGRPDMAQAGGPDAAQADAALQAVRDAMAA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THILA_XENLA
Sequence: MAFCGTRTAARLSHSTRALHNTHRNFASQRTLNEVVIASAARTPIGSFQGTLSSLPATKLGSIAIKAAVERAGIPADEVKEVYMGNVLQAGQGQAPSRQATLGAGLAISTPTTTINKVCASGMKSVMLAAQSLMCGHQQVMVAGGMESMSNVPYCMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKFSISREEQDSFAIHSYTRSKAAWDSGLIANEIAPVTIAQKGKPDIIVQEDEEYKRVDFSKFPKLKTVFQKDNGTVTAANSSTLNDGAAALLLMTTEAANRLNVTPLARIVAFADAAVDPIDFPIAPAYAVPKLLSEAGLKKEDIAMWEINEAFSVVVLANIKMLGIDPARVNMNGGAVSLGHPIGMSGARIVGHMAHALKKGQFGIAGICNGGGGASAVLIEKL
What is the function of this protein?
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA.  Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms.  The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA.  Thereby, it plays a major role in ketone body metabolism.
What are the official names of this protein?
Acetyl-CoA acetyltransferase A, mitochondrial, Acetoacetyl-CoA thiolase A.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRBF_ECOLI
Sequence: MRENKSNPELKIRSTERDYKYISRITGRYAGLSLVFLTAGIVLWTVMDIIFDACIDSWKADPELNNSSYMWNILIYAIPYTLYALAAGFLVTFFSVPNVRINIRKYRDIPAEMSYAPGEHIKGGQE
What are the official names of this protein?
Protein TrbF.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGB_PROMP
Sequence: MMDDSLRVSILSEALPYIQRFSGRKIVVKYGGSIMEDEKLKEAFFRDIALLSSVGVCPVVIHGGGPEINRWLNKLEISPKFENGLRVTDEKTMEIVEMVLMGRVNKQIVRGINKTGSLAVGISGLDGNLIQSRELGDGSHGLVGEVTQINPELLDPLIAKGYIPVISSIGSTADGISHNINADFVAGEVAAAINAEKLILLTDTPGILKEGDNPNSLVKQINLKDARKFIEKNIVSNGMLPKTECCIRALAQGVKAAHIIDGRIEHSLLLEIFTNSGIGTMINA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VASP_CANLF
Sequence: MSETVICSSWATVMLYDDSNKRWLPAGTGPQSFSRVQIYHNPTANSFRVVGWKMQPDQQVVINCAIVRGIKYNQATPTFHQWRDARQVWGLNFGSKEDATQFAAAMASALEALEGGGPPPPPPPAAPPTWSVQNGPASEEVEQQKRQQPGPPEHLERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGVSLSGGSAAGHGAGGGPPPAPPLPTAQGTSGGGTGAPGLAAAIAGAKLRKVSKQEEASGGPPVPKAESTRSTGGGLMEEMNAMLARRRKATQVGEKPPKDESANEEPEARVPVPAQSETVRRPWEKNSTTLPRMKSSSSVTTSEAHPSTPSSSDESDLERVKQELLEEVRKELQKVKEEIIEAFVQELRKRGSP
What is the function of this protein?
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.  VASP promotes actin filament elongation.  It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein.  VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments.  Plays a role in actin-based mobility of Listeria monocytogenes in host cells.  Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
What are the official names of this protein?
Vasodilator-stimulated phosphoprotein, VASP.
What is the protein family that this protein belongs to?
Belongs to the Ena/VASP family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity).
Protein: VE4_HPV28
Sequence: MDDTSAHEKYPLLDLCAPVTPPRRRPKPRWARPKDRSKNDSDSRHSTGSSSSDSTPKPPPRKPLNEQVNHWTLQGPATVTLHVHTPSGTQVTLTVHL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: CH60_TRIL1
Sequence: MSAKEIRFNEEGRNAILRGVNALADAVKVTLGPKGRNVIIEKSFGSPLITKDGVSVAKEVELENKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYKQGSKLVAAGHNPMEIKRGIDKAVEAIVAELQKISKPIKDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVSDPERMEATLENATILIYDKKISNMKDMLPVLEQTAKSGRPLMIIAEDIEGEALATLVVNKLRGVLNVCAVKAPGFGDRRKAMLEDIAILTGGKVISEEMGFKLENTTMEMLGRAKRIVVDKDNTTIIDGDGSEADIQGRVKQIRAQIEDTTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHATRAAVDEGIVPGGGVAYIRALNALDSVVLPAEQQFGVTIIKSSLEAPIRQIADNAGIDASIVVDKVKNGKEAFGYNAADDTYVDMLEAGIIDPTKVSRCALQNASSVAGLMLTTECMIAEKPKKDSGMPAMPGGMGGMGGMGGMDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAR5_ASHGO
Sequence: MLEILLFLCVIIQRSHINAEITHVVSHLAETALRQDTNFQLLSQDIIAKKFPILDSSCVRRALSDFLPQCLQYGFETVPSDVRTQAAVKLSICELQASGVDNMPPECVGAVHFGACLRAMERTPQWWTTYSGNYQHLPSTCFENALPYEKEQLLSLFLNITDVYSNFQDDLVVDLEKYRANFEATVEASLRLMKASLMEGTHEIVNQLKDDLNYVNSKLADMGETITEHTDNVRTVFNDISDELNDYDMAGQIAHLKEDTMSLWQKINSDMGTYHDVQMSSLYNINAVFDTFYNRATESVQQVRTSVIESQLETLDLIADFNSLVRKSILPVLADELQPQLQEMSVSISRSLVGLSASYNEHLQAWSNRVNETLSEMESHLNNTMSQVEHMNDSIETLENKVFVLVSLGNALTTYVKWIYTFSRALISGYGIVTLIMSMLVVRYSIKLNSSWIKVLGRSTFILVAVVLGARTGSMLSY
What is the function of this protein?
Required for nuclear membrane fusion during karyogamy.
What are the official names of this protein?
Nuclear fusion protein KAR5, Karyogamy protein 5.
What is the protein family that this protein belongs to?
Belongs to the KAR5 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Protein: TAW22_NANEQ
Sequence: MSYDIIGEIAIIYPPVDDLDKIVNKILKHHKYVKAIYLKTDKLETELRLPKLKLLYGEPILETTYKENKCVFKLRVDKVYFSPRLSTERKEFIDLVKDNEKILIPFAGVNPYPIVIAKHRKVQIKSIELNPWAVKYGIINTKLNKVNVDTILADFGIAWKYIRNLHNKEGIVTKYVNELLKAKPELDLVYTNEEYYDLLNQYYNTKLIEELKPGIEYFDRIIMPLPKGGEHFIFEALVLAKKYIHLYSFAHEKEIEQKVKEIIDIASQLREIKHYDYKIVGDIGVRKYRIRINIYLI
What is the function of this protein?
Catalyzes both the N1-methylation of guanosine and the C7-methylation of 4-demethylwyosine (imG-14) at position 37 in tRNA(Phe).
What are the official names of this protein?
tRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22, tRNA(Phe):m1G/imG2 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Cytoplasm.