PharMolix/UniProtQA huggingface dataset:
Protein: SOX13_HUMAN
Sequence: MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLSSDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPKAPELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQLLHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMSSSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGELVVLTD
What is the function of this protein?
Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192).  Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity).  Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).  Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity).  Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity).  Promotes brown adipocyte differentiation (By similarity).  Inhibitor of WNT signaling (PubMed:20028982).
What are the official names of this protein?
Transcription factor SOX-13, Islet cell antigen 12, SRY (Sex determining region Y)-box 13, Type 1 diabetes autoantigen ICA12.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CRBN_DROMO
Sequence: MDDEETAEIDETSSSSTNTNTNATAMATATETAAEMHVELEQDEEIPQGSENGAGTGAGDGTRAEAGASAIHAETTAHVSSRARLENMIEEVDNMFEEVSELMVDVTELMRRANQLREDAGTGAVPQNPTVATNTTPPAEIEEEEEGPEQQAEQALVNNDSPSQASISSRHSGSDMSLDSPGSEDDSDAEAVPRWMIPANRVRSAVDMLVSQARNRDGGIATLLRRENFLQRVRSMVFSQDRIRGRASDDANNADVINTVPDDTSEASPPPPLDVDMEEGVRFDTNLPAEHSYFGTNLNRVPGVDYLEVGSTHRMLIFMHQHILFPGEVLPFMIDGNIIDEEIEDTGRDGVIFGVGFPLMQPPDDNPHKLYGVTCQIYEKGESGRQHVFYKSRALQRIVINCDDIQGPPQYIARNPTMKCYSKVKILPEYFLPEPLKCIDMGSLNRFRDIPSMQEKFRRFQLTTTPWPVEACGEYSFEHIVEKARQKLEIHKIDTMPKCPIQLSFWLVRNLHLTEKMMRLTFLTDSVNIRLQIIGTTLKHESLFYCRYCNSSLAYCSDLFAMSKHGVQTQYCNSAGYIHETNTVYRVIAHAIGYSGEPSTEFSWFPGYQWHIIICKFCAQHVGWEFKAVEPNLAPKVFFGLAGSSVRIGKTSERTPTHGSRFVVRNLLRLVSRELE
What is the function of this protein?
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Has an essential role in mediating growth by negatively regulating insulin signaling.  It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
What are the official names of this protein?
Protein cereblon, Protein ohgata.
What is the protein family that this protein belongs to?
Belongs to the CRBN family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACYLL_CAUVN
Sequence: MKAQLMITPTASDRTVRFADFPTLTQALDFAATGETGINLYSLRGELVEALPYAKLRDEAVVLARRLLAIGAKVGDSVALLAETDGDFVRAFFACQYAGLLPAPMALPTPLGGREAYIEQISNLARSAKANILIGPVGLKDWVAEIGARAGLAFAGVLADLPEDAGAALPTITPEDPCYLQFSSGSTRTPTGVLVRHKALMANCVAITRDGLQVRASDRAISWLPLYHDMGLIGFLLSPLSCQMTVDLLPTGAFVRRPLLWIDLIGRNKATIAYSPTFGYELCARRVQGQSLENYNLSHWRSAGLGGDMIRMPPLKAFVEAFAPAGFSDKAFVASYGMAEATLALSMAPLGKGLRAETLDVERLERDALAVDAPEGSERARDFARCGPALPDHFLEVRGDDGQVLPERGVGRIFAKGPSVMSAYFANPEETARVLAADGWLDTGDIGFKIDGEIVITGRAKDLIILNGRNIWPQDLEWTADNEIDGLRSGDVCAFAIPAEPEDEVVVLVQARGGDADSRAALRESVATLLRTRHGVEAKVKLVGAHALPQTSSGKLSRSKAKTAYLAGTYGD
What is the function of this protein?
Involved in de novo bacterial ceramide synthesis.
What are the official names of this protein?
Putative acyl-CoA synthetase CCNA_01223.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: VN1R1_HUMAN
Sequence: MVGDTLKLLSPLMTRYFFLLFYSTDSSDLNENQHPLDFDEMAFGKVKSGISFLIQTGVGILGNSFLLCFYNLILFTGHKLRPTDLILSQLALANSMVLFFKGIPQTMAAFGLKYLLNDTGCKFVFYYHRVGTRVSLSTICLLNGFQAIKLNPSICRWMEIKIRSPRFIDFCCLLCWAPHVLMNASVLLLVNGPLNSKNSSAKNNYGYCSYKASKRFSSLHAVLYFSPDFMSLGFMVWASGSMVFFLYRHKQQVQHNHSNRLSCRPSQEARATHTIMVLVSSFFVFYSVHSFLTIWTTVVANPGQWIVTNSVLVASCFPARSPFVLIMSDTHISQFCFACRTRKTLFPNLVVMP
What is the function of this protein?
Putative pheromone receptor.
What are the official names of this protein?
Vomeronasal type-1 receptor 1, G-protein coupled receptor GPCR24, hGPCR24, V1r-like receptor 1, V3r-related gene protein, Vomeronasal olfactory receptor chromosome 19 subtype I member 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: H4_CHLRE
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRTVLKTFLENVIRDSVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TPIS_SALPB
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELAGVAGCDVAIAPPEMYIDLAKRAAAGSHIMLGAQNVDLNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCS2_SCHPO
Sequence: MSVECSGELFFYPPFTTMSKELISVHNPNPEPVIFKVKTTAPKHYCVRPNSGKIEPKSTVNVQVLLQAMKEEPAPDFKCRDKFLIQSMAIGDADTSNVENYHEFWTEMEKQGRSIFDRKIRCVYSTKQPPQSADKQVENTSTSNPPVSVEGSENLASSVGGPTAVGVSLDEAQNDFNGAKDHLSNGVNTVVPDSTFRSTFESAQIPDASVVQTVVTDADNGAASVKDTIVTAESASSKGADVARSKVQDIIDNEIPKPSESPRRSVSSTPPVHPPPPVPQNLSAVNEEFDTKKNDFDSKLPESTPAVEKVSENLGSETRESLQGAKPAAGAHSSDNALEQIKPSYSADPSSSTGASLTESPGIPPNIVIILCLIFFLIGYLFF
What is the function of this protein?
Vesicle-associated membrane protein-associated protein (VAP) implicated in maintaining the cortical endoplasmic reticulum (ER)-plasma membrane (PM) attachment (PubMed:23041194, PubMed:26877082, PubMed:29290560, PubMed:32023460).  ER-PM contacts function to modulate the distribution of contractile ring components to ensure robust ring assembly (PubMed:26877082).  ER-PM contacts function also in controlling exocytosis and maintenance of cell polarity regulating cell shape (PubMed:29290560).  VAPs play an important role in regulating eisosome assembly (PubMed:32023460).  VAPs also contribute to ER-phagy by tethering atg8 to the ER membrane, but also by maintaining the ER-plasma membrane contact (Ref. 8).
What are the official names of this protein?
Vesicle-associated membrane protein-associated protein scs2, VAMP-associated protein scs2, VAP homolog 1.
What is the protein family that this protein belongs to?
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localizes at the cortical endoplasmic reticulum- plasma membrane contact sites.
Protein: WZYE_YERPY
Sequence: MTLGQFGGLFCIYLIAVIFILTLTYQEFRRVKFNFNVLFSMLYLLTFYFGFPLTCMLVFQFGVAVVPVEYLLYAMLSATAFYGIYYVTYKTRLRQPRSQPRTPIFTMNRVETNLTWVLLALVAVGTVGIFFMQNGFLLFKLDSYSKIFSSDVSGVALKRFFYFFIPAMLVVYFLKQDRRAWFFFLASTVAFGILTYVIVGGTRANIIIAFSLFLFIGIVRGWITLWMLAAAGVFGIVGMFWLALKRYGLDVNGAEAFYTFLYLTRDTFSPWENLGLLLQNYDKIDFQGLAPIVRDFYVFIPSALWPERPDLVLNTANYFTWDVLDNHSGLAISPTLIGSLVVMGGVLFIPLGAIVVGLIIKWFDWLYEQGKAESNRYKAAILQSFCFGAVFNIIVLAREGLDSFVSRVVFFCVIFGACLVLAKLLYWLFDTAGLIKRQGIKSNRLSTPNAGNQL
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_CORU7
Sequence: MTMTDPIADMLSRVRNASNAFHDSVTMPSSKLKAHIAEILKQEGYIEDFAVNDRKDGKAGKELEITLKYGPTRERALAGVRRVSKPGLRVYTKSTNLPKVLGGLGVAIISTSHGLLTDREASNKGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y3364_BACAN
Sequence: MVAHAEIKNLSFVYADENEKALQHISLSVQKGEFIALAGGSGSGKTTLLKHFKKELLPIGKRTGDTYYDGTLLENVPDLLSAQEIGMVFQNPENQLVMDTVIQELAFSLENIGLPSHIIQKRIAELISFLGFQDLLHQSVHTLSGGQKQLVNLAAVLVMQPKLLLLDEPTAQLDPIAAKEFLGLLKRINEELGITIVLSEHRLDEVIPLATRVICMNNGRIVYDGSPKTVVANMWEVEKFRPFIPQIPRLFLEWNAKDIPFTVREAQMKLNDFLAISYVSEPIVQSEKQEVILSAEHISFQYEKNNPLILRDLTVSIEKGKWVALVGKNGTGKSTLLTILAGLQKARRGKVKWNGKVIHKIDSKERFKSIGYVSQHPYYHFTFDTVWDEVYERARELYGEQGKEIAEHQLKKFWLYGLKERHPHDCSGGEQQLLALCTTLLSKPTLLLLDEPTKGLDPWKKERVGELFRKLQKEGTTIVMATHDIEFAAKYVDQCMMLFDGAVIMNDAPKEFFSGNFFYTTSINRFIRKELPYALTWEDVYEACQNDMLHS
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein BA_3364/GBAA_3364/BAS3118.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CAH11_SHEEP
Sequence: MGAAPRLSAPRVLVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVDLKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNLSAATRGPNGLAILSLFVNVAGSSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNGRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDDVPHGL
What is the function of this protein?
Does not have a catalytic activity.
What are the official names of this protein?
Carbonic anhydrase-related protein 11, CA-RP XI, CA-XI, CARP XI, Carbonic anhydrase-related protein 2, CA-RP II, CARP-2.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL1RA_RAT
Sequence: MEICRGPYSHLISLLLILLFRSESAGHPAGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQEDQ
What is the function of this protein?
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A.  Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
What are the official names of this protein?
Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_UREPA
Sequence: MLKQKKFFISTPIYYSSGNPHIGHAYTTIIADVLARYKRLFGYDVFFLTGMDEHGQKIQQKAFEENISPKALVDRNSIIFLNLWKRLNISFSKFIRTTQMDHEESVQKVFSYLYKQGKIYLGQWTGYYCVSCEENYNPAEIIKSQDNIMLCRMGHKLETKSEESYFYKMSDQAPFLKTYYQNHPNFIIPNERANEMVNNFLNNLEDLSISRTTFDWGIPIAENPKHVIYVWLDALMNYLTATGYLSNNEELFQKYWCDNETEIVHLLSKEIARFHCIYWPIFLNDLQIRFPSTILSHGWIITKEGKMSKSLGNVIDPNVLIDTYGVDALRYYLMADLSLFRDAIFSEDNLIETYNTQLANSYGNMISRTLGMLKKYRNNIVPKYVGCVLKNDEKLENLINKNIELVQENINKYSIDKALNCIQEILVEANKYIEDNKPWELAKNQQEQELDSLLVHLVKVIQVTTTLLSPILIEGSKKAVEQLNFDESFLTLASLASYDIFNYHKVNDSKPIFARIIVEKQ
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_PSE14
Sequence: MDDNKKKALAAALGQIERQFGKGAVMRMGDHDRQAIPAISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLSVIAQAQKMGATCAFVDAEHALDPEYAGKLGVNVDDLLVSQPDTGEQALEITDMLVRSNAIDVIVVDSVAALVPKAEIEGEMGDMHVGLQARLMSQALRKITGNIKNANCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRTGAVKEGDEVVGSETRVKVVKNKVAPPFRQAEFQILYGKGIYLNGEIVDLAVLHGFVEKSGAWYSYQGSKIGQGKANSAKFLADNPEICKALEKQIRDKLLTPGVDTKAVGSREAAVADDMAEADADI
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_VIBC1
Sequence: MINEINKDAQERMDKSVEALKNNLSKVRTGRAHPSLLSGISVEYYGAPTPLNQVANVVAEDARTLAITVFDKELTQKVEKAIMMSDLGLNPMSAGTIIRVPLPPLTEERRKDLVKIVRGEAEGSRVAVRNIRRDANSDLKGLLKDKEISEDEDRKAQDEIQKLTDVAVKKIDEVLAAKEKELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP1RB_DANRE
Sequence: MAEVPGTSSETITETVQTGTPPPPQQEGRSLTIKLRKRKTEKKVEWSSDTVDNEHLGRRSSKCCCIYEKPRQFGESSSESEGDDEEGCGSAHCILGHGRRGHGQREGGGTTVPPSSGGTNPH
What is the function of this protein?
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome.  Inhibitor of protein phosphatase 1.
What are the official names of this protein?
E3 ubiquitin-protein ligase PPP1R11, Protein phosphatase 1 regulatory subunit 11.
Protein: NRDI_BRUMB
Sequence: MSLIVYFSSRSGNTHRFVERLGVRSSRIPLEASGALQVREPFVLVTPTYGGGSTKGAVPNPVIRFLNDADNRALIRGVIAAGNSNFGEAFCIAGNIISAKCGVPYLYRFELLGTAEDVGNVRNGMEQFWTRQTQA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: OBG_BURO1
Sequence: MKFIDEARIEVIAGDGGDGSASMRREKFVPFGGPDGGDGGRGGSVYAIADRNINTLIDYRYAKKHLARNGENGRGSDCYGKGGDDVTLRMPVGTIISDMDTGELIADLTEHDQRVMLAQGGAGGLGNLHFKSSTNRAPRQKTDGKPGERRMLKLELKVLADVGLLGMPNAGKSTFISSVSNAKPKIADYPFTTLAPNLGVVRVGPSKSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTGVLLHLVDLAPFDESVDPVAEATAIVGELRKYDEALYEKPRWLVLNKLDMVPEDEREARVADFLDRFGWDGPVFEISALTGQGCEALCYAIYDYLSEHSDAHRAAEAEDLAADVRFRDAPPAKGGATPGDDA
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Protein: MARH1_HUMAN
Sequence: MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.  By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171, RING-type E3 ubiquitin transferase MARCHF1.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: BDH_RAT
Sequence: MLAARLSRPLSQLPGKALSVCDRENGTRHTLLFYPASFSPDTRRTYTSQADAASGKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLLKDKGDAGVRELDSLKSDRLRTIQLNVCNSEEVEKAVETVRSGLKDPEKGMWGLVNNAGISTFGEVEFTSMETYKEVAEVNLWGTVRTTKSFLPLLRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMHPLGVKVSVVEPGNFIAATSLYSPERIQAIAKKMWDELPEVVRKDYGKKYFDEKIAKMETYCNSGSTDTSSVINAVTHALTAATPYTRYHPMDYYWWLRMQVMTHFPGAISDKIYIH
What are the official names of this protein?
D-beta-hydroxybutyrate dehydrogenase, mitochondrial, 3-hydroxybutyrate dehydrogenase, BDH.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion matrix.
Protein: ODO1_COXBU
Sequence: MPKITMQQFQKNSYLADNNAGYIETLYENFLKDPHSVNEEWRSYFRTLTNGASTPDISHATIREEFRELARKPRSISPTAITPAAEQAAVDLLIEGYRRFGHLNAKINPLGDNRPVDSRLELGHYNLTESDFNKTFATYGLLNKPKATLKEIYTRLREIYCGSIGVQYSTISDERERNWLRDYVEQRLPSIEFDKETKRNILQQLVTAESLEKYLDTKYVGQVRYSLEGGDSLIPLLDELTKRARHQKIEEIVICMAHRGRVNVLLNIMGQSAAELFQEFEGKKDYGLMSGDVKYHRGYSRDVKTDAGPIHLSLAFNPSHLEFICPVAMGSVRARQERQNGHKRDYAMTVMIHGDASFSGEGIVMEALSMSQTRAHHVGGSIHIILNNQVGFTTSNPHDARSSMYCSDIAKMLDAPVFHVNGDDPEAVVAVTQLALDYRMAFHKDVFIDLVCYRRHGHQEVDDPMPTQPAMYKVIQEHPTTRTLYAKNLIEKKLCTAEEVDQWIDDYRDRLDRGRQLVETLPEGLSAHYAANWTPYLGQDWTTLVDTTLPLKKLKALGKKFSTLPNTLHLHRKVEAIYKARLEMAEGKTPMDWGFAEMLAYASLLEEGFSVRLVGQDSRRGTFFHRHAVVFDQETGKEYEPLKHLSDKQAAPHIYDSLLCEAGALGFEYGYSTADPNSLVIWEAQFGDFANVAQVIVDQFISSGWQKWNRLSGIVLFLPHGYEGKGPEHSSARLERYLQLCAQNNMQVCAPTTPSQIFHLLRRQVLRPYRKPLVVLTPKSVLRNKLAVSSLEDLARGQLKLLIPEIEKHDPKKITRVILCSGKVYYDLLAKRREHKGKLNHIAMIRIEQLYPFPYDELKAELEKYPNAKQVIWCQEEPKNQGAWFCTRHRLIKCMRDDQTLEYVGRSAFAAPAAGYSALYVKLQEQLVNQALEI
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: SOMA1_XENLA
Sequence: MATGFCSSFGLLVVLLLKNVADVGAFPSVPLFSLFTNAVSRAQYIHMLAADTYRDYERTYITDEQRHSNKNSHVVSCYSETIPYPTDKDNTHQKSDLELLRFSLNLIQSWLNPVQALNKVFSNNLVFGSSDVYERLKYLEEGIQALMQELEDGSFRSFPFLRPPYERFDINLRSDDALVKVYGLLSCFKKDMHKVETYLKVMKCRRFVESNCTI
What is the function of this protein?
Growth hormone plays an important role in growth control.
What are the official names of this protein?
Somatotropin-A, Growth hormone A, GH-A.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTF_ECO57
Sequence: MANYFIDRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTITVSATYPGADAQTVEDSVTQVIEQNMNGLDGLMYMSSTSDAAGNASITLTFETGTSPDIAQVQVQNKLQLAMPSLPEAVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVASNIKDPLSRTAGVGSVQLFGSEYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQLGGMPQAADQQLNASIIVQTRLQTPEEFGKILLKVQQDGSQVLLRDVARVELGAEDYSTVARYNGKPAAGIAIKLATGANALDTSRAVKEELNRLSAYFPASLKTVYPYDTTPFIEISIQEVFKTLVEAIILVFLVMYLFLQNFRATIIPTIAVPVVILGTFAILSAVGFTINTLTMFGMVLAIGLLVDDAIVVVENVERVIAEDKLPPKEATHKSMGQIQRALVGIAVVLSAVFMPMAFMSGATGEIYRQFSITLISSMLLSVFVAMSLTPALCATILKAAPEGGHKPNALFARFNTLFEKSTQHYTDSTRSLLRCTGRYMVIYLLICAGMAVLFLRTPTSFLPEEDQGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKEKDNVQSVFTVGGFGFSGQGQNNGLAFISLKPWSERVGEENSVTAIIQRAMIALSSINKAVVFPFNLPAVAELGTASGFDMELLDNGNLGHEKLTQARNELLSLAAQSPNQVTGVRPNGLEDTPMFKVNVNAAKAEAMGVALSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRMLPDNINQWYVRNASGTMAPLSAYSSTEWTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMKFMADLVAKLPAGVGYSWTGLSYQEALSSNQAPALYAISLVVVFLALAALYESWSIPFSVMLVVPLGVVGALLATDLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPIEAIIEAARMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFVPVFFVVVEHLFARFKKA
What is the function of this protein?
Part of the tripartite efflux system MdtEF-TolC, which confers resistance to various compounds.
What are the official names of this protein?
Multidrug resistance protein MdtF.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUCC_LEPBL
Sequence: MKIHEYQAKEILRRHKANVPFGIVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDATAAVDKILGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTILMASTEGGMEIEEVAETHPEKILKIAVDPGIGLQVNQARQLAFELGLPAESHKSFQSLVMAIYDAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDITEEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFVNIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: NDPA_SALEP
Sequence: MSLDINQIALHQLIKRDEQNLELVLRDSLLEPTTTVVEMVAELHRVYSAKNKAYGLFNEESELAQALRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGIVLFCHYRYLAVEYLLVTVLNNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPQSTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELESLSKELSGVSEVSFSEFTAEKGYELEESFPADRSTLRQLTKYAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLREQLQRRTSGEK
What are the official names of this protein?
Nucleoid-associated protein YejK.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.