Protein: FER3_USTMA
Sequence: MAATTLSRLPALHPYSAVAEPRTLDGTRCFKFMRKSCLEFVKSLVNDEKGEKLISSLAVFVGHLVGCDADEALFKVRFGDGQTRITSAGAVHAQVVDVEASSLPGIAFRFFPPQPTLPKTLDDDLVVTVNSNSDKDVEFVLEFAQTVPSEAGQGIFAYFCKQVLESTLTEDETPLSILNPSPVSKLPEHAQLHDSFLDQAEKFPDRMAVQFLERLDQEDMGQFSKLTYDELKRLATSLAVKLQATHAKTSKPQNRQVVVPMLLCPSLELYVSYLAILMAGFAFCPLPVDAPDARLISLLAQLDTTILLGANSSQPPQWMPASVEWINVTDTLAETDQFAKHLTPAKRMQECAYVLFTSGTTGTPKGVQISHYSASISIFSHAACLDPSLLQLSSNTPGSTFKWFQFASTVFDPSVMEIFVTLSSGGTLCSANRALTLSDLEKVVRLSGADIMMATPSVATLLNPERIPKLKFLWTMGECLNSTVIRRFAAENGRTTLANAYGPTEASVNCTLLQPFPADFRGSIIGAPLPSCSLAVLHDGGDSPSGEKRFQAAPRGVTGELVIGGSHVGIGYLDMPEATADAFTTFAPLGRVYRTRDRARVVWDRDGNPLIEILGRMNAEQVKLSGRRVELGEIDSILQSSHTIQNAASVIWRPPTSQLQSGGGERLVCCIVLAPSAQPQDAEADCKIIADAQLPPHMRPWRYIVLPGLPVTVSGKSDRKQLSKIVAELLSSSAEQGSTKERSSEQNQVNANEDPVTQALIEAICAVCQLDAKSVSMDGDLFELGMDSLSAMRLLQLLRQSKVTATAARQLQVAQILGAKACRDLIPLLSDTTVSRDAEENNVSYPNNTDWSTELRSFEDRCRRSALLGLDERTRMRVQKIFPTTATQSGMLTSFLTRPASIGSKRSYINHTVYHFSSVSEACKFFDAFRTVLQKHDIYRTVFVPVDDKLAPFAQCVLSPASDDDNVSAHTSSTAIDACLKQHLEQIDNAISLEQPPWHLGLLAPPQEDEVEQSVVVLSLMHAIFDGGSLDLLQQEVVSLLRDDALQTSLEVRCTELEATVQHHFTSDLESSRRFWHQRLEGVSRTRFPCANGYKATEQSALGHASEVTELYSRSSMDEIVKQARCQRTSALVLLQTAWNLVLAAYTEDESLNYITSGSVHSGRLDEQTQSCMAPTFNVIPFITRLDQGTGNSATLTSAQLLAEATQASTAGLSHLEIPLGALARSGGMPFDTLFAVQRFDAQTCSNATLPWASISYPVMANDFAVMVEVWPGSKATEKMRLRLTYSLAVLDAPSAQLLLQQYEDILHSLMREPETTTVQQLINGEGLRQSALSVCRGPLASENDDSQTEAQLLHSYFENKAATEPEAIALEFYFNQDSDTDGSMEVQRWTYFELNAQANRLARYLLSVTGKPTLRDLPIPICMERCPELYVGVLATLKAGGAWCPIDVQSPRARQLELIARTKSRVVLVTPNTSADLGEVQADGQPLTIKVNACDTSQFHHLSADNLRPTATPATLAYLIWTSGTTGAPKGVMIEHASAVASMQALQQHVKPLQQDMPPRCLQFSAYTFDVFVQDLFWTWGLGGAIIAATREIMLGSTAELIAASQTSHAHLTPAFAAGLRRDSCPSITSVTFIGEKLTESVAADWTSSCASIDKPNDSIAVYNTYGPAEVTVVATLRQLFGGEKLQSANVGVPMQGVTAIVCKNREQPIRPCAKGSIGELVLAGAQVGRGYLNDKAKTEAAFTYSPEWKQRLYYTGDYVRMLHDGSIEFIGRRDDLVKLGGIRVELSEISAALLSVQERRKQAAVVERVETMMLSRLDRPTKQVISFLACPYLAASTDRGVHGAISEPLLLTSGDAIQLAHQTLNNVRDVLPPYMVPSMVLVLSRIPQTASAKIDRAKLQAAYDSADLAQWVSLLSTTADDPDNPEGEDGDLQCQVIAAISEITGTSTQDINSSSSLVSIGLDSIRAIRLAAKLKQNGTPLPISTLLACSTVRMLIRGLATKTGDGHEVAEEDTRNRLLAVKLSEFDKNVREMLPTGSKQDFEVCIPCSTLQEGMLAETLADPAAYWSDHVLQLDSHIDLARLAEAWRRAAHNIEMLRTVFAVVSQTAGLEEVQFDKNTDVFALQMVHKSVDITLIDVCDPIRVKSDDRLHQAVSKWTRSVAQDRADNVFATPLWKVKTFVVQDDSSSGNDQVPLTYAALCIHHALYDGPSIDIILNRVRDEYSALSPDMLDDHHNIRLLPTTSLSTQSEFAYACVADEQRESILHWEQKLQPRGPAAMLPDLTSVKDLPSDAKSARFIAASRKLQCTSARPQGVGLSALIKSAFAIVLAQYVEAEDQRHVVLGEILSLRNLHATLSTEQGAVGPLLTTQPFSLLLDAALEQKSAASYLQSNVIVHPSMQHRFASLASLAKIMGTRSDQEMFTAMYVYHPRRQPVSVSTKPIWTLLEDRSSEIRVEHSTVLNVFEHDDVEDSLILELSMKEDRISKDMLETLLDQVVSLLTLLLDGAGETLQALLGKVGQDQRELASVSHVPRGSRHAGDGSEVDQGHDPLFWLQHYAKNHPSWLAVVIAAGTPETACINDAELSSWTYAQLNAKADQVARLIRSLDLPSEGPIALCMQRSLISIAVTVAIFKCGRTYLPIDDQLPTERKRLLISDSRCALVVTEGTCLGELEADCISSVLNVSKNDFEQSLAALSHRDDHTELTSIKPRADDGAYLLYTSGSTGKPKGVLVGRANLCSFIDSYAEVVSAECPSTLQLGGKGRYLGLAGRAFDVHLSQMFMSWRFGLALATGERPLLLGDLKATVQTMSITHMSCVPSLLDQCDLVPQEVPSLVFLGVGGEKLTDRVRDTLASSLTVLNAYGPTETTIMCTVNRVHPHSHVRDIGQVLPGNTAVVIDFDDKSRFAPVIRGRAGELCIRGDLVALGYHALDPSQMATSGFVTTPDGTRMYRTGDAARMMADGSLHYLGRRDEQEKIRGQRLELGEVSRCAIAGADESIQATTLICQHESLAKPLLITLIATKTSSTGDQRRDTLPQFLAPSTETGRLAQHVLQYCKQHLPSYMVPDLVVGVSHLTQLAASGKTDVRRLKAWLAAADPTQLFSFEGRGHANAQSGSESNVNRPLSSLEREIASAIRRMLPKCPAEIRPDTSIFDLGIDSLSVIRLAGQLRKEGLAISIGRLRMHPRVQDIAAELSDSKALEVDLSVGVKALESFQARHQDQVQASRVEKVTKVLPCLPSQEGMVAISLSSKDEPVYVARIAVRFNDIQPEATAFAAVSLRRAWRQLSERHSILRTCFDHVDDVTIAQIVLDAVDIQRHIVTTKTQNSTAAIARAILQDITVIPPWRIELDDEAGSEPTFVLHMHHALYDGHSLPLLLNDLARVIQSIDDDGPESHDQQPGVQEMLESILSVSEQRAERFWRNTFADFPVNDPSVWTSIASVQGRAPLRCKATVQLAPLEAAAKTLQVTLSSLVASALGIALCRSLETTAFTVGFVLWGRSLDHVSAESIVAPCLTTVPMPFALCADRGSRHVGELIRACHDWNSSCLAFQHTSMRQIRRWIGSECRGSLVDLLYSFVQAGASNSSELARTWHLDSVEAETDAPAAVEVTADRDRDELRISAMARHLLPHDGLEGMTENLQILLNKIANGTGTNMDLKAAGIPTSSVASKLARELPSHSAVSRPLTAAEEQIRDLAVTMCGVPNTEMLQLDTPFLRIGLDSIVALRFSARLRREHGLQLSAHDVLAAGTIAGLSKLLDQRQAEGRSDATVSSSLDSTAARYKATPLQAGMLNGTLASASHDLYVHHHAVLFKQPLDHDRLQRALQHVVASHDILRTSFHLEGEPSETKNAVNSLSWYAQVTPFESLRSATEIRVVRSDKTASAALKEYGTDFIFDGPEKFNVSPWCAAILHCTSSQDVLVISMHHSLYDGVSLPSMFADLRASYHDLTHELVQRPPFSKAADLIASSAHESEQYWLKTLIEFKQPSLLVKKSSRSSTTPSLYRLDERRLSVSLATLKRLSAELGATPQAIAMLSWSKVLAVAAGQRDVCFGQVVSGRYLNLPGIEDVSGPLINTVPIRINLIDDLASNAVTARDLQERIVAAQPFQHASLGRIQNAWRREHGAHSTFFDTLFVFHNIEGKSSSASSSKSELWTALDPSEGPIQTESSTSTVVTTAASEYPVNISVIQDDDGVQIKAGASDAVGGIDWLPKTLQLFEQVFLDLLERPHRSVGAFPERLAALPLTVGRDGTDKDTSASVGVDAGRRSLSTAEQDIVLRHMAKRLNVDAAIINSCPNLFLLGIDSLLAICISADARSEQVPLTPFDVLSAGTFARLTVATETRSEAPRIGVDDSTDTEREMLVGKEAEQEAIELLKVPSCEVETVLPLLTGQQQHIAQWLQRGRRFLEPTFVYACPSKLDVSKLKSAWNELRRRNAALRTAFVRLKDRRTLVQVVLAENSLVWRDHERGRLGVVDGSNNLDAAAFEAVQRLNASPTDLFRPSARLTLVQGKQSDLVLVTIHHTSYDAWSMRLMADELMQLYHNIDQGKLESMRAPVSFADFIDQTHREALRNRDATASFWETRLRGASATLVCRGATQSLEQTMHVRKPALQDVDTLEAACRARGFGLQVVVILAYARLLSSEVSDTKITSPTFGFYTAGRASAIDGVGNMIGPTTAMQPMTVATAGGDQEDLFERLRAIQTDLVSRAEHQQDYVDLPVAFDAHLNLLWHKPITTSMRPPTDDSNASAPSLLKPYRLPYDSGYFTRHPLMPGNTSVDGDIHEAGAQLYMDVGLDASTKSLSLGARCDRSAMDAQQLEAFCDRFVGELEKIRAAL
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence (PubMed:17138696, PubMed:20070524).  The first step of ferrichrome A biosynthesis is performed by the HMG-CoA synthase hcs1 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (PubMed:20070524).  The enoyl-CoA isomerase/hydratase fer4 then catalyzes the conversion of hcs1-produced HMG-CoA to methylglutaconyl-CoA (PubMed:20070524).  The acyltransferase fer5 then fuses the fer4-generated methylglutaconyl-CoA with sid1-generated hydroxyornithine to yield methylglutaconyl hydroxyornithine (PubMed:20070524).  Methylglutaconyl hydroxyornithine is then available for use by the NRPS fer3 to generate ferrichrome A (PubMed:20070524).
What are the official names of this protein?
Siderophore peptide synthetase fer3, Fe-regulated protein 3, Ferrichrome A biosynthesis protein fer3, Nonribosomal peptide synthetase fer3, NRPS fer3.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.