PharMolix/UniProtQA huggingface dataset:
Protein: OL734_MOUSE
Sequence: MEPANDTTVTEFILTGLSQTREVQLVLFVIFLSFYLFILPVNILIICTIRLDSHLSSPMYFLLANLAFLDIWYSSITAPKMLVDFFVERKIISFGGCIAQLFFLHFVGASEMFLLTVMAFDRYAAICRPLHYATIMNRRLCCILVALSWTGGFVHSIIQVALIVRLPFCGPNELDNYFCDITQVVRIACANTFLEEMVMIFSSGLISVVCFIALLMSYAFLLTMLKKHSSSGESTSRAISTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFHTVIFPLLNPIIYTLRNKEVKAAMRKLVNRYIFCKEK
What is the function of this protein?
Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984).  Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (PubMed:32337066).  In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (PubMed:31798959).  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (PubMed:31230984).
What are the official names of this protein?
Olfactory receptor 734.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VAS1_RAT
Sequence: MMAATVVSRIRTGTRWAPVLWLLLSLVAVAAAVAAEQQVPLVLWSSDRDLWAPVADTHEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLKELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLESEDVPYTAALTAVRPSRVARDVAMVAGGLGRQLLQTQVASPAIHPPVSYNDTAPRILFWAQNFSVAYKDEWKDLTSLTFGVENLNLTGSFWNDSFAMLSLTYEPLFGATVTFKFILASRFYPVSARYWFTMERLEIHSNGSVAHFNVSQVTGPSIYSFHCEYVSSLSKKGSLLVTNVPSLWQMTLHNFQIQAFNVTGEQFSYASDCAGFFSPGIWMGLLTTLFMLFIFTYGLHMILSLKTMDRFDDRKGPTITLTQIV
What is the function of this protein?
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:32165585).  Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity.  Involved in membrane trafficking and Ca(2+)-dependent membrane fusion.  May play a role in the assembly of the V-type ATPase complex.  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).  In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit S1, V-ATPase subunit S1, C7-1 protein, V-ATPase Ac45 subunit, V-ATPase S1 accessory protein, Vacuolar proton pump subunit S1.
What is the protein family that this protein belongs to?
Belongs to the vacuolar ATPase subunit S1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Note=Not detected in trans-Golgi network.
Protein: Y168_UREPA
Sequence: MALKTNTIIKSKWNPSNFDINIDIKEMIARTAQESTVNDVILKTKDNVPLEWMEFIDNINENNEILKLIKGDCRIKSLYGINYVGFEIYNNDILIFNADINNAMNKSIRINQQQEYSSTIYRKIALMKDSEYLSLKELHTPYEIKRLIYNSTGVYKIIFNEFEVSTPMYFKDIFKNKNVVHNYGVLCTKEFLNRSFIDFENKINEKLPDWYPVNDLINDTNALLNFIKKERELNKTRIVGSIINHNDAQTYRNQWIDEIQYMSSDLILNTNTPDKNAFEIMQSTFNESIHLQAITEKLNLIFKGCGYVWNMGDSLSYQNSETATNLNKATFETQKWK
What are the official names of this protein?
Uncharacterized protein UU168.
Protein: Y2019_BACC1
Sequence: MRDNTIGSLIWLRLIRFTNQSNQMSNEFLKRFDLTTAQFDVLLQIRTYQPLTQMELAEKVTVTQGGISRMLTRLEKEGYIVRKQDWKTKTISLTEQGEAALERALPEQLAFQSSFFDDVLNEEEQKMLYELMTKVHKHSEKKELPQE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator BCE_2019.
Protein: ENO_FRACC
Sequence: MPSIEAVGAREILDSRGNPTVEVEVVLEDGTLGRAAVPSGASTGAFEAVELRDGDNRYGGKGVTKAVAAVIDRIGPAIMELEATEQRLLDATLIDLDGTPGKSALGANALLGVSLAVAKAAAASSGLPLFRYLGGPTAHLLPVPMMNILNGGAHADTNVDIQEFMIAPIGASTFAESLRWGAEVYHALKSVLKARGLATGVGDEGGFAPSLPTNREALDLIAEGIDKAGFALGTDIALALDVASTEFYADGSYTFEGNSRSAEYLSDYYAELVSAYPIVSIEDPLAEDDWDGWVALTERLGGKVQLVGDDLFVTNPERLARGIALKAANALLVKVNQIGTLTETLDAVNLAHRSGYRAMMSHRSGETEDTTIADLAVAVDCGQIKTGAPARSERVAKYNQLLRIEEELDDAARYAGAAAFPRRRQAG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: Y091B_ABVP
Sequence: MNTLKIYALMKKHKLIREPEKADDYLLQKLDREIELIEHGPLFAKKVTAQISDHDKELVDFIFSLIKEECYKESYTFEKITDCLMKFEEKI
What are the official names of this protein?
Uncharacterized protein ORF91b.
Protein: TSAD_SHIDS
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCTA_SHIFL
Sequence: MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: RS12_HALSA
Sequence: MTNGKYAARKLKKDRQQRRWSDSEYARRERGLGKKSDPLEGAPQGRGIVLEKVGIEAKQPNSAIRKCVRVQLIKNGKQVTAFCPGDGAISFIDEHDEVTIAGIGGAKGRAMGDLSGVNYKVEKVNGVSLIELVRGNAEKPVR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12, HmaS12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: COF_SALTI
Sequence: MARLAAFDMDGTLLMPDHHLGRETIATLSRLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: IFNA8_HUMAN
Sequence: MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE
What is the function of this protein?
Produced by macrophages, IFN-alpha have antiviral activities.  Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
What are the official names of this protein?
Interferon alpha-8, IFN-alpha-8, Interferon alpha-B, LeIF B, Interferon alpha-B2.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: BPT_PARPJ
Sequence: MTHPNELPLSPLSALQFYATAPYPCSYLDGRIARSQVATPSHLINSDVYTDLVKAGFRRSGVFTYRPYCDGCRACVPVRVPVDQFEPNRTQRRVWKKHGELIATVAPLHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFREPLRDQADAPGILRMISMIDILGDGLSSVYTFFEPGLPNTSFGTYNIYWQIEQARSLKLPYVYLGYWIRESPKMAYKANFRPLEGLIDGAWCVLDPTSVDLPPVDLAIHGKRPPLKP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_HYPBU
Sequence: MPTWHYSVRVDEEKSAKAMVWDAPISYKKIVELARLLKGMKVDEARRFLERVARGEEPIPVRRYSGKQAHHRGLAAKYKWPIGRYPVKAAKILLRLLDNVTNNAEVKGLDTERLRIVHIAVHKGRVLKRWMPRAFGRATPKFKKYSHIEIVVAEEE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TSSF1_PSEAE
Sequence: MNPRLLEYYNQELQHIRESAAEFAEEFPKIAGRLSLSGFECADPYVERLLEGFAYLTARVQLKLDAEYPTFTHNLLEIAYPHYLAPTPSMTVVQLRPDPNEGALSSGFSIERGASLRGQLGPDDQTACEYRTAHPVTLWPLEVAQADYFGNPAAVLGRLAASEPRAKAGLRIRLRSGAGIPFDSLSLDALPLYLHGADEQPYRLYEQLLGNACAVFVRAPDNAWVERLPTSSLRARGFDDEDALLPVVPRAFQGYRLLQEYFALPARFLFVEFSGLNRALRRCHGEELELVVLFGKHDQRLEGTVDAEQLVPFCTPAINLFPRRCDRIHLSDRVNEHHVIVDRTRPLDFEVHSLQQVSGHGSGPEQPFQPFYAVRDPARYGREQAYFRVRREPRVLSSKQRRKGPRSTYVGSETFVALVDANQAPYRHDLRQLGIAALCTNRDLPLFMPIGAHKSDFTLEDSAPVMQVRCLAGPSRPRASRAHDASAWRLISQLSLNYLSLAERGQGAAALRELLRLYGDSGDPALQLQIEGLREVSSKPCTRRLPMPGPIVFGRGLEITLDFDENAFRGTGVFLLGAVFERFLARYVSINSFTETVLRTGERGEVMRWQAKPGSRPNL
What is the function of this protein?
Core component of the H1 type VI (H1-T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species.
What are the official names of this protein?
Type VI secretion system component TssF1.
Protein: Y711_LEGPC
Sequence: MAGHSKWANIKFRKGVQDAKRGKIFTKLIREITVAARMGGGDESSNPRLRDAVKKALNANMKRDTIDNAVKRGVGGADGEAMIAMRYEGYGPGGVAILVDCLSDNKNRTVSEVRHAFSKHGGNLGTDGSVSYLFTNQGEILMASNQPEDKVMEIAIDAGASDVAVEDSQVEIITPVEAYHTVLNALQDAGLEVEQSHLTMRAQTLVPISDETAESLIKLIDMLEDLDDVQEVYSNAEFSEKILESMN
What are the official names of this protein?
Probable transcriptional regulatory protein LPC_0711.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR14_CHAGL
Sequence: MAKKSIIHRDKKRENLVKKYQEIRNSIKENIKQAKSLNEKWELQKQLQALPRNSSPTRIHRRCFVTGRPRAVYRDFGLSRHVIREMAHSCLLPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LSPA_SALG2
Sequence: MSKPLCSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVGLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGICVILLVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGNWHFATFNLADSAICIGAALIVLEGFLPKPTAKEQA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UPPP2_BURL3
Sequence: MSLWFLVFLSVLQGVTELFPVSSLGHTLLVPALFGMHIDKHAPQLLPFLVALHLGTALALLWYFRARWVALIGGFFAQLGGRKNDDGHLMWALIIGTIPTGIVGLLLEKRIERVFHDLRIVAIALIVNGVLLWLGDRIQRSRAHQAPEKMTFKQAFFVGLAQIGALIPGFSRSGLTMIAGNAAGLTAEKAAEFSFLLGTPIIFAAGVLELPKLFHARDQLADALLGGVLTAIAAYLSVRFLMRYFEGRGRLASFGVYCVIAGVFCLGWFMLHPQPV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YH24_CAEEL
Sequence: MSLQSLLSTKIVRATSIADAAFDAVVLVGSQDNVQQFGAIQQVSAIAPAVNNFLKLHSGAFNSTSLVQVDSSVVPSGRLILSGTGNVSRDYDDVRRYQAAARKGISMALSAGVKSPLLITLPNSRFPNAELVAALGALTPVYTPLNVREEENKQKLNQLGLLAIGNSDTSARLEKLVEAYDASFTVCRDVGEAGPERMAPPRVAEYIQGAFANGNIKVTVVDDQSVILKDFPLMAAVNRAANCVKEHQARLIRLEYVGEGETQDTFFVVGKGVTIDTGGCDLKTGGHMFGMCRDKYGSAVVGGFFKAIDVLKPKNIKAVGYMCMVRNSIGSHAYTCDEVITSRSGKRIHIYNTDAEGRLTMLDPLTLAKEEALNAKNPHLFTVATLTGHEVLSYGYYAAIMDNGPAKASGWARRVQNVGDEFGQPIEISRLHPEDFAFHMAECEQADLRQGNTKPSVATLRGHQTPAAFLQMASRIDEHGTNSSHPLKYSHIDMGGCSGDHPSVSFPNPLVTLVAGLVLPHV
What are the official names of this protein?
Putative aminopeptidase W07G4.4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
Protein: Y4MC_SINFN
Sequence: MVFSFSTFNRLVTFTVMAAIVSVRPLTAEDLSSQQQWPGTPLSRVEALAVLQTLNANLLSNASATLTLDRWCEAHRLAPPGSKIVAKHVQGHDKPANVHIRKLLHVGPNEPIVYRHVRLACGDRILSEADNWYVPARLTAEMNEVLNTTDISFGRAVRSLNFTRTNLTARLLWSPLPEGWDMSAELPVSSSGPLIPPPFLLEHHAVLKLQDGTPFSAVVESYTNNVLDFPAPLLYPQ
What are the official names of this protein?
Uncharacterized protein y4mC.
Protein: CLFA_STAAN
Sequence: MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQNTDASNKDVVSQAVNPSTPRMRAFSLAAVAADAPAAGTDITNQLTDVKVTIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVDNKENVTANITMPAYIDPENVTKTGNVTLTTGIGTNTASKTVLIDYEKYGQFHNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVVLPALTGNLIPNTKSNALIDAKNTDIKVYRVDNANDLSESYYVNPSDFEDVTNQVRISFPNANQYKVEFPTDDDQITTPYIVVVNGHIDPASTGDLALRSTFYGYDSNFIWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSESDSDSDSDSDSDSASDSDSGSDSDSSSDSDSDSTSDTGSDNDSDSDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEANTSLIWGLLASLGSLLLFRRKKENKDKK
What is the function of this protein?
Cell surface-associated protein implicated in virulence.  Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen.  Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing.  Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed.  Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis (By similarity).
What are the official names of this protein?
Clumping factor A, Fibrinogen receptor A, Fibrinogen-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Protein: SQHC_ZYMMO
Sequence: MTVSTSSAFHHSPLSDDVEPIIQKATRALLEKQHQDGHWVFELEADATIPAEYILLKHYLGEPQDLEIEAKIGRYLRRIQGEHGGWSLFYGGDLDLSATVKAYFALKMIGDSPDAPHMLRARNEILARGGAMRANVFTRIQLALFGAMSWEHVPQMPVELMLMPEWFPVHINKMAYWARTVLVPLLVLQALKPVARNRRGILVDELFVPDVLPTLQESGDPIWRRFFSALDKVLHKVEPYWPKNMRAKAIHSCVHFVTERLNGEDGLGAIYPAIANSVMMYDALGYPENHPERAIARRAVEKLMVLDGTEDQGDKEVYCQPCLSPIWDTALVAHAMLEVGGDEAEKSAISALSWLKPQQILDVKGDWAWRRPDLRPGGWAFQYRNDYYPDVDDTAVVTMAMDRAAKLSDLRDDFEESKARAMEWTIGMQSDNGGWGAFDANNSYTYLNNIPFADHGALLDPPTVDVSARCVSMMAQAGISITDPKMKAAVDYLLKEQEEDGSWFGRWGVNYIYGTWSALCALNVAALPHDHLAIQKAVAWLKTIQNEDGGWGENCDSYALDYSGYEPMDSTASQTAWALLGLMAVGEANSEAVTKGINWLAQNQDEEGLWKEDYYSGGGFPRVFYLRYHGYSKYFPLWALARYRNLKKANQPIVHYGM
What is the function of this protein?
Catalyzes the cyclization of squalene into hopene.
What are the official names of this protein?
Squalene--hopene cyclase, Squalene--hopanol cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS4_BURCH
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACTAFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDYGVESIVYTDIGRDGMLQGINIDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKRADELNGELDNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_STAAS
Sequence: MPTINQLVRKPRQSKIKKSDSPALNKGFNSKKKKFTDLNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNNIEINAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDTSGVDGRRQGRSLYGTKKPKN
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: TATB_AERHH
Sequence: MFDIGFWELVVIGVVALVVLGPERLPVAIRTASHWIRLIRSTANSVKAELEQELKLQDLHNDLKKAEQLQMNNLSPELQESIEQLKTAAQSVTRPYEQQNTIQPASAVAEVKEEPVAPISVATPDEEPTVIPAARAQPSAEQGEVKP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LI15A_CAEEL
Sequence: MLAPAAPAKDVVSADEKEEIIAKRKFRMKNVDAMRMSSLANDRMAFNKKCNALAMKFVKSAGIGTDALQLTCFQELVRHFNPIAAVVVGVKREPNSNVQAEKKTIPKVKTIQTPTQSMESVRLLQEKKASATEEQSAESASIMKHFANTIPNSTPTQSVKDVLTAAASKGQFKSSAEIFSHFPSEPSPSKPRATREGSQPSDYTYCTYLTPCILCEKALLMRESIAMTDNEAVKVLMAAVMSGHFRMATAEKAIRHERLRMCYDHVDFVYEMMCDAFEAKTESEINEMPPDRLMRGHDIYRALKRVGDLHKGKVTSNTPLYSFKNSIKSYYRNHVPRMVNGSLSKPSPKPFSELVALLQSVPPSTNLNELLNHNLSLSDADKQELIQLINGKDNRFTSRRRKIEDILDNKFAAAAAKAYRDHSEDAPSEPYIPNQSEMQNTVERRKRKLHSPEQDDAGSSSISWNAKKTKTPIDYVHLATRVLEGHSIADEALLHKSKVSYARNAFGEKPSSPTPPSAPLKFCVVNGKKYLRFENGTGPPKVVVQGNVVLRTNTLKDALTTAPRAQNQPSTSTDSSSSSEMEGIRQSFGAPQKEEEEEELVPTLLQNKPTHVESSSPVEKKPPTKTNVEKPAVRLGRMLTTAFGSMSYRTRKSVENKTDLLNQPTSASPRRMIKVVRNRNPHLAKQVAAAPSEPKHIPPTHMEKKPEELLMDPKPEPIF
What is the function of this protein?
Synthetic multivulva (synMuv) class A protein (PubMed:7982579, PubMed:8054684).  SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684).  Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway (PubMed:8054684, PubMed:16624904).  May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1 (PubMed:11463372).  Regulates let-23 basal activity (PubMed:8054684).  Required for the correct expression and/or stability of lin-56 (PubMed:21196525).
What are the official names of this protein?
Protein lin-15A, Abnormal cell lineage protein 15A.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOZ_DESVH
Sequence: MARITVEDCQKRIDNRFLLVQMAIKRVQQYREGYEPLVDSKNKEVVTALREIAAGKVMPEDLALYRPAEGEEMPVAE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: NANE1_STRPN
Sequence: MSQIWTKEKFISQVQGGVIVSCQALPGEALYNEEFSLMPFMAKAALEAGAVGIRANSVRDIKAIQKVVDLPIIGIIKRDYPPQEPYITATMKEVDELVECGTTVIAFDATLRPRYDGLVVSEFIKKIKEKYPNQLLMADVSNLDEGLYAFKSGVDFVGTTLSGYTSTSVQSDEPDFELMKKLADFNIPVIAEGKIHYPEQLKKAYSLGVTSVVIGGAITRPKEIAQRFINVIK
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase 1, ManNAc-6-P epimerase 1.
What is the protein family that this protein belongs to?
Belongs to the NanE family.