PharMolix/UniProtQA huggingface dataset:
Protein: SPAI_PIG
Sequence: MRSRSFLVLVAVFLICETLVAQRLDRIRGPKGQGQDPVEGQDQDEGPGPVKVEILDIGQDPVKGQDPVKGQDPVKGQDPVKGQDLVKSQDPVKAELPDIGQDVVKGHEPVEGQDPVNAQLPDKVQDPVKAQPAVPGRFLLSKRGHCPRILFRCPLSNPSNKCWRDYDCPGVKKCCEGFCGKDCLYPK
What is the function of this protein?
Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+).
What are the official names of this protein?
Sodium/potassium ATPase inhibitor SPAI-2, Protein WAP-2.
Protein: KARG_SCYSE
Sequence: MADAAVIEKLEEGFKKLEAATDCKSLLKKYLTKSVFDQLKGKKTSLGATLLDVIQSGVENLDSGVGVYAPDAEAYTLFAPLFDPIIEDYHKGFKQTDKHPNKDFGDVNQFVNVDPDGKFVISTRVRCGRSMEGYPFNPCLTEAQYKEMESKVSSTLSNLEGELKGTYYPLTGMTKDVQQKLIDDHFLFKEGDRFLQAANACRYWPTGRGIYHNDNKTFLVWCNEEDHLRIISMQMGGDLGQVYRRLVSAVNEIEKRVPFSHHDRLGFLTFCPTNLGTTVRASVHIKLPKLAANREKLEEVAGKYSLQVRGTRGEHTEAEGGVYDISNKRRMGLTEFQAVKEMQDGILELIKMEKEM
What is the function of this protein?
Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine.
What are the official names of this protein?
Arginine kinase Scy s 2, AK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: HSLU_SYNWW
Sequence: MFKLTPREIVEELDKYIIGQQEAKKAVAIALRNRYRRKLLPDELREEIYPKNIIMIGSTGVGKTEIARRLARLVKAPFIKVEASKFTEVGYVGRDVDSMVRDLVETSIRLVKQEKMAAVEQKGRQMAEERIVDILLPFDGRKSKSPKNPFEFLLGSIQERDDVDDESERRRREIGQRREILRQKINRLELEDETIEIEVEEKNPSFMEIFSGSGVEEMGINLQDMLGNLMPRNKKKRKVSIAEARRILTYEESQRLLDMDEIHREGIKRAEEDGIIFLDEIDKIASKESNYGPDVSRGGVQRDILPIVEGSTVITKYGPARTDHVLFIAAGAFHVSKPSDLIPELQGRFPIRVELESLKKEDLKRILTEPNNSLIKQYIALLSTEKLTMDFTPEAIDYIAERAYEVNSRTEDIGARRLHTVMEKLLEDLLFNSPDMAGEKLVIDIDYVAERLDRIVEDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALR1_ARATH
Sequence: MAKLNPKFISLILFALVVIVSAEVIFEEKFEDGWEKRWVKSDWKKDDNTAGEWKHTAGNWSGDANDKGIQTSEDYRFYAISAEFPEFSNKDKTLVFQFSVKHEQKLDCGGGYMKLLSDDVDQTKFGGDTPYSIMFGPDICGYSTKKVHAILTYNGTNHLIKKEVPCETDQLTHVYTFVLRPDATYSILIDNVEKQTGSLYSDWDLLPAKKIKDPSAKKPEDWDDKEYIPDPEDTKPAGYDDIPKEIPDTDAKKPEDWDDEEDGEWTAPTIPNPEYNGEWKPKKIKNPAYKGKWKAPMIDNPEFKDDPELYVFPKLKYVGVELWQVKSGSLFDNVLVSDDPEYAKKLAEETWGKHKDAEKAAFDEAEKKREEEESKDAPAESDAEEEAEDDDNEGDDSDNESKSEETKEAEETKEAEETDAAHDEL
What is the function of this protein?
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle.  This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).
What are the official names of this protein?
Calreticulin-1.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: BPT_JANSC
Sequence: MRHTLPIAPQFYVTAPQACPYLDGRRERKLFTALQGDQAETLNNSLSKQGFRRSQNVLYRPSCTDCAACLSARIRVADFAPRRGHKRISRRNEHLFRNPRSAWATEEQYALFRTYLDTRHADGGMADMDVFEFAAMIEETPVKTRVIEYRDRTDGDDLAAVCLTDILDDGLSLVYSFFAPELQKNSLGTYVILDHIALAQEAGLPYVYLGYWVPGSTKMGYKASFPALEVHVNGDWQDIGDPADYDTQTHPLSTDPIAQQVAQITLPDLRGENGRSDGLRGFSDGP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGGPS_METTH
Sequence: MKVEDYFHDILRERKIHLTLIDPEEQTPEEAVEIARAAIRGGTDGIMLGGSTTDSSELDNTARALRENIDVPIILFPGNTTGVSRYADAIFFMSLLNSTNPYWIIGAQALGAATVKKMGIEALPMGYLVVEPGGTVGWVGDTKPVPRNKPDIAAAYAMAAEFLGMRLFYLEAGSGAPEHVPEEMIALVKRCTDQILIVGGGIRSGEDAARVAGAGADVVVTGTVVENSDNVEDKIREIVEGMGSV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, MtGGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_LACDA
Sequence: MKTKEIRSLSTDELLAKEKQYKEELFNLRFQQATGQLENTARLSQVRKNIARIKTILSEKELEQN
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y2436_VIBVY
Sequence: MSNKDNDLDDDFSLFREAVQGIKKLPQDTIVQQPNRNTKQKEIKRISREASDSEFYFSDEFVPLLSEEGPTRYARDDVSTYEVKRLRRGVYVPDVFLDMHGMTQQEAKRELGAMIAYCVKNEVHCACVQHGIGKHILKQKTPLWLAQHPDVLAFHQAPLEFGGDGALLVLLSIPEK
What are the official names of this protein?
UPF0115 protein VV2436.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: FLIT_YERPG
Sequence: MERHQHLLSEYQQILTLSEQMLMLATVENWNALVDLEMTYLKAVENTANITISSCTSPVLQELLRQKLRSILENEIEIKRLLQRRLDKLSELVGQSTRQQAVNRTYGQFPDQALLLGETQ
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SYT_STAAS
Sequence: MEQINIQFPDGNKKAFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTKPLETDGSIEIVTPGSEEALEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDDFEQIEKTMKQIVNENMKIERKVVSRDEAKELFSNDEYKLELIDAIPEDENVTLYSQGDFTDLCRGVHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEERKERDHRKIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPMQLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSYEEAIGEAAFYGPKLDVQVKTAMGKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFVAFLTEETKGAFPTWLAPKQVQIIPVNVDLHYDYARQLQDELKSQGVRVSIDDRNEKMGYKIREAQMQKIPYQIVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKKHR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHEB_DROME
Sequence: MPTKERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIFPVQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYVPVVLVGNKIDLHQERTVSTEEGKKLAESWRAAFLETSAKQNESVGDIFHQLLILIENENGNPQEKSGCLVS
What is the function of this protein?
Binds GTP and exhibits intrinsic GTPase activity (By similarity).  Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis (PubMed:22493059).  Stimulates the phosphorylation of S6K through activation of TORC1 signaling (PubMed:22493059).  May also have a role in activating TORC2 signaling (PubMed:22493059).
What are the official names of this protein?
GTP-binding protein Rheb homolog.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rheb family.
What are the subcellular locations of this protein?
Endomembrane system; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
Protein: CYK3_SCHPO
Sequence: MSIPKQLPCMVRALYAWPGEREGDLKFTEGDLIECLSIGDGKWWIGRHINTNTQGIFPSNFVHCLDIPTVRPGSSMSRTSASSFRYSSPQKSSIDTPITSSDQGLTPDLVGSSNALNKPTRESDSLKHQKSHPMLNSLGSSLSLKKSVSRPPSSMSRTNLDVSSRWDNTADNDSQIDAQDLSRSTPSPLRSAMENVLQSLNAMGKKSFSRANSPLLRLTKSTTTSKETDFIPVPPAHGSTSMTSRSKLDDSTDNSSKPRTSLQPGESPMKSSRDISRKPSMASSVLSPSDYFPQHRRFQSAPAPIPRPVSTLIPLTQVRTTASNVIKPRPQTTERPSTAQSFRKGGGFLKKTFKKLLRRGSSKRKPSLQPTPPVSYPAHNVPQKGVRPASPHTLKSVKDDLKRTKTYTKAEFAAKREEIFNKLSMPVYEPLKDLSECIGNVLADGEPVQFSVGTNIHNMNFSAIDKQIRSIIPQRVQVSPAVLAKNYLAPGQTTALAQMRAVFIYISERITFTNQTLDNDELRTSTQVISEGQGTPFEVALLVKEMLQALDLWCEVIEGYLKSPDDIYYTRDININHAWNVVTFDNEVRLIDASFASPTHPQQALKSSSSNDFYFLMKPNECIFTHVPENPDQQFIMPDLSMPIVMALPWVSSVYFTLGLKLRKFNTSILHLNDLEVLQIEFLAPKDIECVAEVDALSALAPTADVSQCYKYTLTQAFWETPDIRVMRVKAVMPANNRAAVLRIYAGRLGVSSPVRTAPHPMAMSLPFVHHGKNKALEFVTRHPVPHCPSVDLYINSPQCGTLHSGVEYKFNVSAYACQPSTSISNTRLAIQTPTGNIVRLREERSGNGVIFFSLSLTINETGEYRALILAEKIGRWVVYATWQAV
What is the function of this protein?
Involved in cytokinesis.
What are the official names of this protein?
cytokinesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the CYK3 family.
What are the subcellular locations of this protein?
Cell tip. Cell septum.
Protein: ATPF_BARVE
Sequence: MKNLTDSFVYLGHWPSAGSFGFNTDILATNPINLSVVFGVLIFFGKGVLNDLLDNRKQRILNTIRNSEELREGAIQQLENARARLRKVETEADQFRVNGYSEIEREKLNLINSTYKTLKQLENYKNETILFEQQRTINQVRERVFQQALQGAIGTLNSCLSHELHLRTINANIGMFGTMKEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CYSN_SHEWM
Sequence: MTTSSNLISSDIEEYLKVHENKDMLRVLTCGSVDDGKSTLIGRLLFDSKMIFEDQMAAIEKDSKRFNTTDDSFDLALLVDGLQSEREQGITIDVAYRYFTTEQRKFIIADTPGHEQYTRNMATGASTCDLAIILIDARHGVQVQTRRHSFICSQLGIKHVIIAINKMDAIDYDQATYQKIKKEYREFAEDLSFSDVRFVPISALKGDNVVNESPNMTWYPGSTLLKLLNTVSVEQDRSESFRFQVQYVNRPNLDFRGFCGTIGSGEIRVGDTVATLPSNKESRVKSIVTFDGELEKAVAGQAVTLTLEDEIDISRGDMLVRPHDKPFSVSHFEADVVWMTEEPLCVDREYAIKVGSKSVYGYADAINHKVDVNTLEKQSAQQLALNEIGNCHFAVTEPVQFDAYDTNRSTGSFIIIDRLTNVTVGAGMIRNPIEVKSTKAHEYSEFEIEMNALVRKHFPHWGAKDISKG
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: FRDC_ECOUT
Sequence: MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVALYW
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Fumarate reductase 15 kDa hydrophobic protein, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYP_ACET2
Sequence: MRVSNMFFQTLREVPAEAEIASHQLMLRAGLMRKLASGIYSFLPLGYRVFRKIEQIVREEMDRAGAQELIMSALLPAESYQASGRWEVFGAEMFRLKDRNGRDFCLGPTHEEIFTETVKSVTRSYRSLPLILYQIQTKYRDERRPRFGVMRSREFVMKDAYSFDRDEAGLDISYKKMYDAYCRIFDRLGLDYIIVDADTGAMGGSDSQEFMVKSAVGESRIAYCEACGYAANDEKAECVPEKCCDDKECCGELGLEKVATPDVRTIEELMQFFGCSAKEFAKTLIYKADDKVVAAMVRGDRELNETKLQNLLGCIELEMADAETVEKVTGAAVGFAGPIGLDIDIVVDLEVAEMKNFVVGANETGFHYKNVNINRDFKPKYVKDIRTIKEGDACPKCGAPVKVEFGIEVGHIFKLGTKYSEALDCIYLDETGKERPMIMGCYGIGINRSMAAVIEQNNDENGIIWPISIAPYHVIVIPVNTTDSVQMELAEKIYTQLGEMGIEVLLDDRDERPGVKFKDADLIGIPIRITVGKRAGEGIVEYKLRREKDFAAIPYEEAIAKAKKEVAEGLKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_SHESW
Sequence: MNIRPLHDRVIVKRLEVESTSAGGIVLTGSAAEKSTRGEILAVGNGRILENGTVKPLDVKVGDVVIFNEGYGVKKEKIDGQEVLILSEADLMAVVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_GEODF
Sequence: MARVTVEDCLEKVDNRFLLVMLASKRVKQLFKGAKPLIDNRAANKNVVVSLREIAAGKVNFEISSRKSR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RSMH_ALIFM
Sequence: MSEQFQHVSVLLHESIDGLAIKPDGIYIDGTFGRGGHSRQILSQLGENGRLYSIDRDPQAIAEAKTITDPKFTIIHGPFSGLKQYVEELELVGKIDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLQEADVEDITWVIREFGEDKHAWRIAKGIVAYRENEENEPLTRTSQLAKLISEVAPKSFKEKKHPATRAFQAFRIYINSELDEIDTALKGALDVLAPEGRLSVISFHSLEDRMVKHFIRKESKGPQVPHGLPLTEEQIKALGSAKMKPVGKAIKPTKNEVDVNVRSRSSVLRIAERL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERLN1_DANRE
Sequence: MAHVGAVVAAMAGLMAILLHSSIHKIEEGHLAVYYRGGALLTSPNGPGYHIMLPFITSYRSVQTTLQTDEIKNVPCGTSGGVMIYFDRIEVVNMLIPTSVVDIVRNYTADYDKTLIFNKIHHELNQFCSVHTLQEVYIELFDIIDENLKTALQKDLNCMAPGLTIQAVRVTKPKIPEAIRRNYELMEAEKTRLLITVQTQKVVEKEAETERKKAIIEAQKVAQVAEIQFQQKVMEKETEKKISEIEDAAFLAREKARADAEYYTAAKFAEANTLKLTPEYLQLMKYQAIAANSKIYFGQDIPNMFVDSSASRPAAGESEQLESLSMRESLKKASKPKASEGH
What is the function of this protein?
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).  Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.  Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
What are the official names of this protein?
Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Protein: PDUL_ENTFA
Sequence: MNKLDSMNEIVEEVVKRIQQQQQNTFEVEASGRHVHLSRQEIDALFGPGYQLTKVKDLSQPGQFVCKERITVAGPKGLFQNVVILGPERSESQVEVSMTDTRILGINAPVRESGKTEGTPGVTLMNGSAVVTLSHGLIVAKRHIHMTPEDALKNKVSNSQIVQVKVEGTRPLIFDDVVVRISPRFATYMHIDYDEANACGLTKGARGYILK
What is the function of this protein?
Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
What are the official names of this protein?
Phosphate propanoyltransferase, Phosphate acyltransferase PduL, Phosphotransacylase PduL, PTAC, Propanediol utilization protein PduL.
What is the protein family that this protein belongs to?
Belongs to the PduL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_PARXL
Sequence: MTTALDQLKQYTTVVADTGDFQQLAQYKPQDATTNPSLILKAVQKDDYKPLLEKTVKAHASKPVGAIIDQLLIAFGTEILKIIPGRVSTEVDARLSFDTEGSIAKGRELIALYKEHGIGRERVLIKLASTWEGIRAAEVLQKEGIHCNMTLLFSLAQAAACAEAGAQLISPFVGRIYDWYKKNAGSAWDEAKDGGANDPGVKSVRRIYAYYKKFGYKTEVMGASFRTPGQILELAGCDLLTISPDLLQKLHESTEKVERKLSPDIAKESDIERVPVDESSFRFLVNDEAMATEKLAEGIRAFAADAIKLEKLIDALR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBA_PASMU
Sequence: MAKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDALYSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRYNTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: NDHK_EUCGG
Sequence: MNSIEFPLLARTTQNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKIAREIYEERIRSQEENRCFTTNHKFHVGRSIHTGNYDQGLLYQSPSTSEIPPETFFKYKSSVSSHELVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: TATA_METCA
Sequence: MGIGVWELLLLFLIVLVVFGTKRLRNIGGDLGGAIKSFRQAMSENEDKPSEGGARTLEGEVVDKKEKDKV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RUVA_DESOH
Sequence: MIGYLEGTLLKKKEDRILLLAGPVGYEVLLPAVVMASLQGKREGDPLFFHIYHYQTERQPKPVLIGFNTEEEKDFFHLLITVEAIGPLKAVQCLTLPIGEVAEAIETGNSALLGQLKGVGGRTAQKMIATLKGKVGRFADAGHSSAPDVPVTGSLADQTVEVLVGQLGYKPNEARLMVAGALKRNPDVSTPEALFDEIFKHGQAQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: GREA_RHORT
Sequence: MEKIPMTPDGLARLEAELKSLKSVDRPAVIRAISEARDHGDLSENAEYHAARERQSFIEGRIKELEDVTSRAEVIDISKLSGDTVRFGATVSVLDEDSEEQTTYQIVGAHEADLKAGRISVASPIGKALIGKKVGDSIEVKAPGGSKFYEVTMVRFG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.