PharMolix/UniProtQA huggingface dataset:
Protein: SERC_COXBU
Sequence: MSRVYNFSAGPAAIPEEVLFTVRDELLDWHGIGMSIAEVSHRGEEFIGVAEEAERDLRELLAVPESYHILFLQGGSRLQFDMVPMNLLANHKKAVYIDSGVWSNLAIREAKNYCDPHLATNAKELNYTGIPDQATWDMPNEAAYFYYVDNETVNGIEFPFIPDTDLTLVCDMSSNLLSRPFDVSRYGLIFACAQKNMGLAGLTIVIVHDDLLKRSPLPTTPSYLQYALHAKERSFINTPPTFAWYLAGLIFKWVKNQGGVAVLAERNQRKAAKLYKFIDKSNFFDNPINPTYRSRMNVIFRLADERLNSLFLKEATENGLANLKGHRLLGGMRASIYNAMTEEGVDALINFMGQFEKRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAD2_DICDI
Sequence: MSTLGDKESIIFKEKSFGGEKWSLQNGSRYGNQAGALRSLKVGKFCKVNIWDKNGTMQTFLGGEYPDITDKLPNVDIVQAIDVQFKYSVDIRFKHNVQGRDPNDFKLTVIPYQLNGVEIVSGGDYSGVQIPELNPPDSEIVCQISIREIKWPGQVFANGSIYFKYTPSNNTVSYRKTEGWPTNCEIVQDDVSGFTITLKSI
What is the function of this protein?
Mediates calcium-dependent cell-cell adhesion during the early stage of development.
What are the official names of this protein?
Putative calcium-dependent cell adhesion molecule 2, CAD-2, DdCAD-2.
What is the protein family that this protein belongs to?
Belongs to the Dictyostelium CAD family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: YIDC_LARHH
Sequence: MDTKRLIVFIVLSFGLLFVWQEYFAPKPQPKPVAAAVQPDGTPAPATARPADSPATGKLTSAQTITVTTDLVKAQINTAGGDIRSLELLTQGAIDNPDKPFMLMTEQGGRTYVAQSGLLSSDASLPTHKTLYAADKTAYTLLPDQNTLTVTLAAAPVNGVEVKKIFTFKRDSYVIDVRYDIINHSDKPVDATAYYRLLRDGKAPEGESSMAHTFTGPAVYTETGKFQKVSFEDLAKGKGDYVRQADNGWVAMVQHYFVSAWILKTNDGKSVCSSAEACQFELKPAAGDLYSAGVLVKLPVVAAGQQYSIDMPLYAGPEDTRRMATVAPGLVLTKDYGWVTIIATPLFWLLDKLYGLVHNWGWAIVLLTVLVKAAFYPLSAASYRSMAKMKALAPRMQRLKEQYGDDRQKFQQATMEMYKTEKVNPLGGCLPIVVQIPVFIGLYWALLASVELRQAPWILWIHDLAKPDPYYILPALMAATMYLQTFLNPPPADPLQAKMMKIMPLAFSVMFFFFPAGLVLYWLVNNILSIAQQWWVNKQIEKDAAKAKSS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL25_SORC5
Sequence: MDIIKLNATRREDSGKSASSRLRRAGQIPAIAYGRELAPQSVAISPKALLQVLGSDHGKNSVVELAIENGQTLTVMVRDYDYHPISRELVHADFIQVKLDQPVDVQIPFRCVGKPKGVVTGGVLQQIFRTIPVRCLPEKIPSFIEIDVTELDLGDSYKASGLKLPEGVKTLLADDQTIAVVNAPEKAGPEEEAKPAAGAPAAGAAAAPAAGAAAPAKGAAPAADKKDKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: DED1_CRYNB
Sequence: MAATDVNGLASQMNSVNLNGASQKPQKPAYVPPHLRNRAAPPAAVPPAAPAAYRPSPTGLPTPATTPPTRHIVPAAVAEDDVGGWGAQPRVRKTFEHGAPPGFGSWKNGQHVVGARNTRMEKEMYGEVGDGLHQATGINFDKYADIPVEVSGKGVPEPVTEFTNPPINPVLLENVKYARYATPTPVQKYSIPIVADGRDLMACAQTGSGKTGGFLFPILSALFTYGPSTPPVEQDTGYGYRRTKKVYPTALVLAPTRELVSQIHEEARKFAYRSWVRPAVVYGGADIGSQMRALDRGCDLLSATPGRLVDLIERGKISLANVKYLVLDEADRMLDMGFEPQIRRIVDEEDMPGVLERQTLMFSATFPREIQNLARSFLKEYIFLTVGRVGSTSENITQRVEYVDDQDKRSLLLDLLLAEQSGGLILVFVETKRMADTLCDFLCSRRHNATSIHGDRTQREREAALYAFKSGRAPILVATAVAARGLDIPNVTHVILYDLPNDVAEYTHRIGRTGRAGNVGTSTAFFNRGNTNIGKDLIELLKEANQEVPQWLVEISSERSYGGGGGGGYKGSRGRSTGGGGGARLGGRDMRQGGGGYGGGGRTSGYGGGYGGGGGGAGWGSGGGFPPAGGDSGASWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase ded1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B4GN4_MOUSE
Sequence: MPWFPVKKVRKQMKLLLLLLLLTCAAWLTYVHRSLVRPGRALRQRLGYGRDGEKLTGVTDSRGVRVPSSTQRSEDSSESHEEEQAPEGRGPNMLFPGGPRKPPPLNLTHQTPPWREEFKGQVNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVTKLAVSPKWKNYGLRIFGFIHPARDGDIQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASRRYYFELLHKQDDKGSDHVEVGWRAFLPGLKFEIIDSAHISLYTDESSLKMDHVAHVPQSPASHIGGFPPQGEPSADMLHPDPRDTFFLTPRMEPLSLENVLEPCAYAPTYILKDFPIARYQGLQFVYLSFIYPNDHTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGEEDEEEEVQRRAFLFLNPDDFLDEEDEQDLLDSLEPTDASVQQSHRTPTPAASTGTTASPTPPTTSPLDEQTLRHSRALNWAPRPLPLFLGRAPPPRTVEKSPSKVYVTRVRPGQRASPRALRDSPWPPFPGVFLRPKPLPRVQLRVPPHPPRTQGYRTSGPKVTELKPPVRAQTSQGGREGQLHGQGLMVPTVDLNSSVETQPVTSFLSLSQVSRPQLPGEGEEGEEDGAPGDEATSEDSEEEEEPAAGRPLGRWREDAINWQRTFSVGAMDFELLRSDWNDLRCNVSGNLQLPEAEAVDVVAQYMERLNAKHGGRFSLLRIVNVEKRRDSARGSRFLLELELQERGGSRQRLSEYVFLRLPGARVGDEDGESPEPPPAASIHPDSRPELCRPLHLAWRQDVMVHFIVPVKNQARWVVQFLADMTALHVHTGDSYFNIILVDFESEDMDVERALRAAQLPRYQYLKRTGNFERSAGLQTGVDAVEDPSSIVFLCDLHIHFPPNILDSIRKHCVEGKLAFAPVVMRLGCGSSPWDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRHFYHHYHSKRGMWATRSRKGARAQRS
What is the function of this protein?
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
What are the official names of this protein?
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1, NGalNAc-T1, Beta-1,4-N-acetylgalactosaminyltransferase IV, Beta4GalNAc-T4, Beta4GalNAcT4.
What is the protein family that this protein belongs to?
Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: RL28_STAHJ
Sequence: MGKQCYVTGRKASTGNNRSHALNANKRRFNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TLP8_PHONI
Sequence: QKKDKKDRFY
What are the official names of this protein?
Tachykinin-like peptide-VIII, P.nigriventer tachykinin peptides VIII, PnTkP-VIII, U29-ctenitoxin-Pn1h, U29-CNTX-Pn1h.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TOLB_PHOPR
Sequence: MMKRWMMGLCIALLSFSQIAQAELELVITEGIDSARPIGIIPFTWEGEGKLPTDISSVIASDLQRSGKFSPIATSKMPQTPDSEEQIDYRAWTAMGVDALVTGKVTKNAEGNYVVNYQLVDVVRGQLTSGESRGLANGELVLTKDHLLVNNRAIVKETRLRQYAHRISDVVYEALTGEQGAFLTRIAYVVIDDKSKHPYQLRVADYDGFNERLVLKSRQPLMSPAWSPDGSKLAYVSFENQQAQIYIMDIYKGTRELVTSYPRHNGSPRFSPDGKKLALVLSKTGSLQIYIKDLKTKKLTQITSGRANNTEAFWDPDGKSLIFTSDRGGQPQIYRVNLADNSTKRLTWQGSQNLGGQLTPDGRYLVMVNRSDTGFNIAKQDLKTGAVQILTKTFLDESPSIAPNGGMVIYSSVNNKSNELSLVSIDGRFKARLPTTNGRVRAPSWGPFL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FLIW2_HELHP
Sequence: MTYELKMPILGFDATKIELEKIDETFSKIRGLDGKQPFEITLINPFSLCDYAFTIPTADERLLDLDESRGDKVEVYCVVVLQKPIENSVVNLMAPFVFNPANACALQVTTLPVAEYPQFSKVLPLKEFLSKEILETLNR
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW 2.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_MYCLE
Sequence: MASSTDVRPKITMACEVCKHRNYITKKNRRNDPDRMELKKFCRNCGKHQSHRETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: LIPA_SORMK
Sequence: MRPGSWRVITHYGFTGPIQRLQAPLRRSLARAAALSTRSYATIPSAPSSQPTSQESSPAASASASASAPATKPRPTYFKDTTLASLDDFIANQSSAAPLAPSEAYTLRTAQVGPAGKKRTITRLPEWLKTPIPSAGANPEFAKIKADLRGLNLHTVCEEARCPNIGECWGGSNKAAATATIMLMGDTCTRGCRFCSVKTSRKPPPLDPHEPENTAEALARWGLGYVVLTSVDRDDLADGGARHFAETIRRIKQKKPTLLVEALTGDFMGDLDMVKIVADSGLDVYAHNVETVENLTPYVRDRRATFRQSLKVLEHVKNVRGKEGIITKTSIMLGLGETEEELWDALRELRKVDVDVVTFGQYMRPTKRHLAVEKYITPDEFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLKKRASERVVSEALGQAVAAEEATSAKSA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS6_YERPP
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYSATITNAAGTIHRLEDWGRRQLAYPISKLHKAHYVLLNVEAPQEAIDELETNFRFNDAVIRSMVMRVKHAVTEASPMVKAKDERRERHDFASEANDDSEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PDX1_EMENI
Sequence: MAATNGASNDFTVKAGLAQMLKGGVIMDVVNAEQARIAEEAGAAAVMALERVPADIRAQGGVARMSDPSMIKEIMEAVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADNLYHVTKHNFKAPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRTVNAEIARARAILQSSPDPEPELRAYARELEAPYELLREAAEKGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAKKRAKAIVQAVTHYKDPKVLAEVSQGLGEAMVGINVSHMKDEDKLAKRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by PDX2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.  Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit pyroA, PLP synthase subunit pyroA, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: TAL_VIBVY
Sequence: MSNKLEQLRKLTTVVADTGEIDAIKKYQPEDATTNPSLILKAAQIAEYAPLIDASIEYAKTQSDDKAQQIQDTCDMLAVNIGKEILKTIPGRISTEVDARLSYDMEGSVAKARQLVKMYNDAGITNDRILIKLASTWEGIRAAEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRIMDWYKAKEGRDFEAQEDPGVLSVTKIYNYYKEYGYKTVVMGASFRNIGEILELAGCDRLTIAPALLAELEAAEGEVVEKLVDSKGAAERPAPMTHAEFLWEHNQDPMAVEKLAEGIRNFAVDQGKLEAMIAAKL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPLT_YERPG
Sequence: MSQDVLADKPLLSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQIADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGEQLVKANGMMEASTIAAILLGSVAGGILADWHLMAALGVCALVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGAGVTLRFLLVLWVPVALGIADNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGVLIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLGENTAMLFMLGLYSLVVKLGAPVVAVGVGFGVVFALAIALLWGWQWRQQRQKTRQPE
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDHI_SQUKU
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: XPO7B_XENLA
Sequence: MADPVQSLAQLEILCKQLYETTDTSTRLQAEKALVEFTNSPECLSKCQLLLERGSSSYSQLLAATCLTKLVSRSTNPLPLEQRIDIRNYVLTYLATRPKLASFVTQALIQLYARITKLGWFDSQKDDFVFRNVIGDVTRFLQDSVEYCVIGVSFLSQLTNEINQADATHPLTKHRKIASSFRDSALFDIFTLSCNLLKQASGKSLLLSDESQHDLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPNFTPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHLLETYTPEVTKSYVTSRLESVHIILRDGLEDPLEDAGLVQQQLDQLSTIGRCEYDKTCALLVQLFDQSAQTYQELLQSGSAPSMELAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELSMLSFFEQFRKIYIGDQVQKSSKLYRRLSDVLGLNDETMVLSIFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINSQSNMSDMRCRTTFYTALGRLLMVDLGEDEEQFSQFMMPLTAAFESLAQMFNSNNFNEQEAKRSLVGLVRDLRGIAFAFNAKSSFMMLFDWIYPAYMPILQRAIELWFHDPACTTPILKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITTYGNRILTLGELPKEQLYVLKLKGISICFSVLKAALSGNYVNFGVFRLYGDEALDNALQTFVKLLLSVPHSDLLDYPKLSQSYYSLLEVLTQDHMSFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSGKKRGAPPPQESERFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRSSIVSSQPPEKQQAMHLCFENLMEGIEGNLLTKNRDRFTQNLSAFRREVNDSMKNSSCGPNSNEMMS
What is the function of this protein?
Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
What are the official names of this protein?
Exportin-7-B.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CCME_METPP
Sequence: MKPRQKRLVLIVGIVAAVGVAAALVLNAFQSNLVFFYSPAQVAAKEAPVGRAFRLGGLVDGGSVQRDGLVVRFVVTDTVKSIPVRYQGILPDLFKEGKGVVAQGQLGDDGVFVAREVLAKHDENYMPPEAAEALQRAGASNQKLGETVVKETRP
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: TVA34_HUMAN
Sequence: METVLQVLLGILGFQAAWVSSQELEQSPQSLIVQEGKNLTINCTSSKTLYGLYWYKQKYGEGLIFLMMLQKGGEEKSHEKITAKLDEKKQQSSLHITASQPSHAGIYLCGAD
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 34.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MMP16_MOUSE
Sequence: MILLAFSSGRRLDFVHRSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin.  Activates progelatinase A.  Involved in the matrix remodeling of blood vessels.  It has no effect on type I, II, IV and V collagen.  However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity).
What are the official names of this protein?
Matrix metalloproteinase-16, MMP-16, Membrane-type matrix metalloproteinase 3, MT-MMP 3, MTMMP3, Membrane-type-3 matrix metalloproteinase, MT3-MMP, MT3MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.
Protein: AZOR_CERS1
Sequence: MTTILRIDSSIKGEAAVSRRLTQRILDRLLEAHPDATVVSRDLAQGIRQIDGPWLGSVFTAPEQRTADQQEIARTADAVMAEVKEADILVIALPVYNFGAPAQLKSWVDHIARRGESFVYTETGPVGLLTGKRAIVAFTSDGTPLGSELDHASGWLRQVLGFVGITDVDFVAADRMVFGADEAMARAEAAVAALAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: DALD3_DANRE
Sequence: MEESAPFSIVSTVKALSGALRGDAGHEADISREREKLWFKESSAKNLRNRDFLAPNTVLTTLYAGGEVPSDILSAVHTLRGSGVLPIGATEVTTEGLRVCVDRCAAFRGVLCGIMPYLKPAAQRQGCVLINCPALHTKQSVPSPDTLALGQLRTILIADHLGAQLRRQGYTVSFCPALPQESDIVNFLKTLGIDWPTVPVSWTNEDREEKMKKALENSAYRDRETEKGKRRSRGEEIEGEKRGLKEDVRINLKQVVQDENLNGYDPSLGTCTVQREALCHLAQLDSATADFPASTTTALHVTSCQDEFRQQQTAMLWRAAGATALQRLVICGPVKTPGVQMNAAQYFQLRKAQMKEASEMKYGDQVEGQTWDDIIRVMTSATVRFELLSTVHTSPVTLDVQRDSGVSTKGPRGGVFVMYNCARLHTLFSSYEKGVEQGLYPEIPGGTELDFSALKEEGEWLLLFNYLIPFSEILDQSAQTLEHEGGGARVQLRTEQVCRFLVSLSKDFSSYYNRVHVLGEPLPHLFNQMFCRLLLLRALRELYHSALDSLNLPPIPQL
What are the official names of this protein?
DALR anticodon-binding domain-containing protein 3.
Protein: CRYAA_PELLE
Sequence: MDITIQHPWFKRALGPFYPNRLFDQVFGEGMFDYDLFPFLSSTISPYYRQSFFRGFLDSGISEVRSDRDRVKHFSPEDLTVKILDDFVEIHGKHSERQDDHGYISREFHRRYRLPSNLNESSISCSLSADGILTFSGPKLMSSLDSSHGERPIPVSREEKPTSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock.
Protein: PPDK_FLABR
Sequence: MSSLFVEGMPLKSANESCLPASVKQRRTGDLRRLNHHRQPAFVRGICRRKLSGVSRIELRTGGLTLPRAVLNPVSPPVTTTKKRVFTFGKGNSEGNKDMKSLLGGKGANLAEMASIGLSVPPGLTISTEACEEYQQNGKKLPPGLWDEILEGLQYVQKEMSASLGDPSKALLLSVRSGAAISMPGMMDTVLNLGLNDEVVDGLAAKSGARFAYDSYRRFLDMFGNVVMGIPHSLFDEKLEQMKAEKGIHLDTDLTAADLKDLAEQYKNVYVEAKGEKFPTDPKKQLELAVNAVFDSWDSPRANKYRSINQITGLKGTAVNIQCMVFGNMGNTSGTGVLFTRNPSTGEKKLYGEFLVNAQGEDVVAGIRTPEDLVTMETCMPEAYRELVENCVILERHYKDMMDIEFTVQENRLWMLQCRTGKRTGKGAVRIAVDMVNEGLIDTRTAIKRVETQHLDQLLHPQFENPSAYKSHVVATGLPASPGAAVGQVVFSAEDAETWHAQGKSAILVRTETSPEDVGGMHAAAGILTARGGMTSHAAVVARGWGKCCVSGCADIRVNDDMKVFTIGDRVIKEGDWLSLNGSTGEVILGKQLLAPPAMSNDLETFMSWADQARRLKVMANADTPNDALTARNNGAQGIGLCRTEHMFFASDERIKAVRKMIMAVTPEQRKAALDLLLPYQRSDFEGIFRAMDGLPVTIRLLDPPLHEFLPEGDLEHIVNELTADTGMSKDEIYSRIEKLSEVNPMLGFRGCRLGISYPELTEMQVRAIFQAAVSMNNQGVTVIPEIMVPLVGTPQELRHQIGVIRGVAANVFAEMGLTLEYKVGTMIEIPRAALIADEIAKEAEFFSFGTNDLTQMTFGYSRDDVGKFLPIYLSQGILQHDPFEVLDQKGVGQLIKMATEKGRAANPNLKVGICGEHGGEPSSVAFFDGVGLDYVSCSPFRVPIARLAAAQVVV
What is the function of this protein?
Formation of phosphoenolpyruvate, which is the primary acceptor of CO(2) in C4 and some Crassulacean acid metabolism plants.
What are the official names of this protein?
Pyruvate, phosphate dikinase, chloroplastic, Cold-sensitive pyruvate, orthophosphate dikinase, Pyruvate, orthophosphate dikinase.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MOAC_STAAN
Sequence: MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.