PharMolix/UniProtQA huggingface dataset:
Protein: KYNU_STRMK
Sequence: MSDLLSRTHAIALDAADPLRPLRNEFLIPRHGGGEQTYFVGNSLGLQPRGAQAAVQEVMKQWGELAVEGHFTGPTQWLSYHRLVSAQLARVVGALPSEVVAMNTLSVNLHLMMVSFYRPTAQRPVILMEAGAFPTDRHAVEAQIRFHGFDPAECLVEVQPDEANGTISLTAIERAIAEHGPRLALVLWPGVQYRTGQAFDLDAITRAARLQGARIGFDLAHSVGNLPLRLHDVAPDFAVWCHYKYLNSGPGAVAGAFVHERHHRDTTLPRFAGWWGHEEATRFQMAPQFTPAIGAEGWQLSNPPILGLAPLRASLDLFERAGMEALRSKSLALTGMLEALVRARLSGVLDIITPAEPQRRGCQLSLRVIGGRERGRALFEHLRGIGVLGDWREPDVIRISPTPLYNRYLDVHHFVEEVEAWAGL
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: SPEB_ECOSE
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDIDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: CP2K4_ONCMY
Sequence: MSLIEGLLQTSSTVTLLGTVLFLLVPYLRSSGSSSEEQGKEPPGPRPLPLLGNMLQLDLKKPYCTLCELSKKYGSIFTVHFGSKKVVVLAGYKTVKQALVNQAEDFGERDITPAFYDFNQGHGILFTNGDSWKEMRRFALTNLRDFGMGKKGSEEKILEEIPYLIEVLEKHEGKAFDTTQSVHHAVSNIISAIVYGSRFEYTDPLFTGMVDRVNENVHLIGSASIQMYNMFPWLGPWINNLTRLKKNVADLKMEVIELVRGLKETLNPHMCRGFVDSFLVRKQTLEESGKMDSFYHDDNLLFSIGNLFGAGTDTTGTTLRWGLLLMAKYPHIQDQVQEEISRVIGSRQTLVEDRKNLPYTDAVIHETQRLANISPMAVPHTTSRDVTFQGYFIKKGTSVIPLLMSVLQDDNEWESPNTFNPSHFLDEQGGFVKRDAFMAFSAGRRVCLGEGLARMELFLFFTSLLQRFRFSPPPGVTEDDLDLTPLLGFTLHPSPHQLCAVSRV
What are the official names of this protein?
Cytochrome P450 2K4, CYPIIK4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: THII_UREU1
Sequence: MKPIIYIKYGELTLKGKNRAQFIKVLVHNIKQMLLEYHELVYQVGYDNLKIINLEKYNLQQVINDLQQVYGIAFICVAYQVNKEINEIQLACNKLVNNTDQTFKIEARRNDKSFIYDSMQIKQICATYLLQNQPTLKVDVHHPQLLINIEIKHDCAIVYGHKIPGAKGLPVGINGKALVLLSGGIDSPVASRLIMKRGISVDFITFITPPHTSQKALDKTIALAKQITLNNHLTKANLYVCNFTKLQEEIAHISKESYRITLMRRYFMRIAKRLAIDIKAGALVTGEALGQVASQTLNSMQTISSVLNDFLVLRPLITYDKQEIISLAKQFNTYELSILPYDDSCSLFAPKNPTTNPNVQTAMKLEQESLVLDAIYELVFTKEITKINLSSK
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_SULAC
Sequence: MNPLRLYNTLGRRIETFESFDPLTVKMYVCGPTVYDYVHIGHGRAFVGFDGIVRYLKLRGFNVIRVQNITDIDDKIIKRANETGKDWREIVDYYTKDYMESLKALKVEIDQHPRVTSHIQEIIDFVQKLVDKGHAYITSSGSVYFDVDSFPSYGLLSGSKKEEWNQGEEIVKEKKNPYDFALWKAWKPGEPYWESPWGKGRPGWHIECSTMSTRYLGEQFDIHGGGVDLVFPHHENERAQSESLLGKIWVKYWVHVAYLTINKEKMSKSLGNIIPLNEALKKWGPSVLRFWYLSTKYRNSIDYSEQTLEQARSSLQRLKDAMGIIRSVIKEEPKSHSNEEEISTQREIISLIGKFHEAMSNDFDTATALSNIYEIANLVFTKIQYTRDFMGAMLAFDAFRQFNYVFGVMDEEFSPSYETMYKVIDSVVEIRNILRARKMYDLSDEIRSVLANAGIKILDGKEKSTWRFE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_SHEON
Sequence: MKVDPNKEKALAAVLSQIEKQFGKGSIMKLGEDRSMDVETISTGSLSLDVALGAGGLPMGRIVEIYGPESSGKTTLTLEVIAAAQREGKTCAFIDAEHALDPIYAKKLGVDIDNLLCSQPDTGEQALEICDALTRSGAVDVIIVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRTGAIKEGDEVVGNETRVKVVKNKVAAPFKQAEFQILYGQGINRTGELVDLGVAHKLIEKAGAWYSYKGDKIGQGRANAGKYLTENPAIAAEIDKTLRELLLSNPSALASSASDDDNVEGNIDLETGEVF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR2_PHAVU
Sequence: MTKRYWNIILEEMMEAGVHFGHGTRKWNPKMSPYISANRKGIHITNLIRTARFLSESCDLVFHAASGGKQFLIVGTKKKAADSVARAAIRARCHYVNKKWLGGMLTNWYTTKTRLQKFRDLRMQQKTGRFDCFPKKDAAILKRHLAQLETYLGGIKYMKGLPDIVIIIDQQEEYTALRECITLEIPTICLIDTNSDPDLADISIPANDDAIASIRFILNKLVFAICEGRSRSIRNS
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CDPK_SOYBN
Sequence: MAAKSSSSSTTTNVVTLKAAWVLPQRTQNIREVYEVGRKLGQGQFGTTFECTRRASGGKFACKSIPKRKLLCKEDYEDVWREIQIMHHLSEHANVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGHYSERQAARLIKTIVEVVEACHSLGVMHRDLKPENFLFDTIDEDAKLKATDFGLSVFYKPGESFCDVVGSPYYVAPEVLRKLYGPESDVWSAGVILYILLSGVPPFWAESEPGIFRQILLGKLDFHSEPWPSISDSAKDLIRKMLDQNPKTRLTAHEVLRHPWIVDDNIAPDKPLDSAVLSRLKQFSAMNKLKKMALRVIAERLSEEEIGGLKELFKMIDTDNSGTITFDELKDGLKRVGSELMESEIKDLMDAADIDKSGTIDYGEFIAATVHLNKLEREENLVSAFSYFDKDGSGYITLDEIQQACKDFGLDDIHIDDMIKEIDQDNDGQIDYGEFAAMMRKGNGGIGRRTMRKTLNLRDALGLVDNGSNQVIEGYFK
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase SK5, CDPK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
Protein: SDHL_STRCO
Sequence: MAISVFDLFSIGIGPSSSHTVGPMRAARMFARRLRNEELLDSVASVRVELYGSLGATGHGHGTPKAVLLGLEGDSPRTVDVESADDRVETIKSSGRISLLGDHEIAFAYDDDMVLHRRKALPYHANGMTLWAYDAEGAEVLTKTYYSVGGGFVVDEDAVGADRIVLDDTVLKYPFRTGDELLRLARETGLSISALMLENERAWRDEDEIREGLLEIWRVMRACVDRGMTREGILPGGLKVRRRAANTARKLRSEGDPQALAMEWITLYAMAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYMNFVPGADEDGVVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGALAEVLGGSPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNGMAAVKAVTAARMAMRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNIIEC
What are the official names of this protein?
L-serine dehydratase, SDH, L-serine deaminase, L-SD.
What is the protein family that this protein belongs to?
Belongs to the iron-sulfur dependent L-serine dehydratase family.
Protein: YPFN_ECOLC
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GERPF_BACAN
Sequence: MPSVVGNLVVQNSNGSFNLGDFYNVSPKENTKAYNGSGASNVGFVVNTFNGVSATNTFDSDVADQDQIGTA
What is the function of this protein?
Required for the formation of functionally normal spores.  Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor.
What are the official names of this protein?
Probable spore germination protein GerPF.
What is the protein family that this protein belongs to?
Belongs to the GerPA/GerPF family.
Protein: ESYT3_MOUSE
Sequence: MQPEEPCAPSAPGGPDVPERGQRSRDPGPRLSGQLLPELYSFVARVLFYLAPVYLAGYLGLSVTWLLLGALLWMWWRRNRRGKLGRLEAAFEFLEHEREFISRELRGQHLPAWIHFPDVERVEWANKIIIQIWPYLSMIMENKIREKLEPKIREKSIHLRTFTFTKLYFGQKCPKVNGVKVHTDKRNRRKVTLDLQICYIGDCEISVELQKIRGGVSGVQLQGTLRVILEPLLVDKPFIGAVTVFFLQKPHLQINWTGLTNLLDMPGINELSDSLLEDLIAAHLVLPNRVTVPVKKGLDVTNLRVPLPCGVIRVHLLEAKKLAQKDNFLGLGGKSDPYAKVSIGLQHCRSRTIYKNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDKDDFLGSLQICLGDVMKNRVVDEWFALNDTTSGRLHLRLEWLSLLTDQEALTENDSGLSTAILVVFLENACNLPRNPFDYLNGEYRAKKLSRFVKNKASRDPSSYVKLTVGKKTFTSKTCPHSKDPVWSQVFSFFVHSVAAEQLCLKVLDDELECALGVLEFPLCRILPCADLTLEQCFQLDHSGLDSLISMRLVLRFLRVEGRELGSPYTGPDALKKGPLFIKKVATNQGCKAPPLNEGLADVTSTSNPASYIKGASKSIDNISAATTDPEPMPEPQGPGPEPKGKDSARGLCESPGKKKNPATTFLTVPGLHSPGPIKSPRPMSRPAFPFAWPLTRVAPSMSSLNSLASSCFDLTDVSLNTEAGDSRQGRLGEIQLTVRYVCLRHCLRVLVNGCRNLTPCTSSGADPYVRIYLLPERRWASRKKTSVKQKTLEPLFDETFEFFVPMGEVQKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKQDLIKGFSQWYELTADGQPRS
What is the function of this protein?
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.  Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).
What are the official names of this protein?
Extended synaptotagmin-3, E-Syt3.
What is the protein family that this protein belongs to?
Belongs to the extended synaptotagmin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity).
Protein: CYSD_SHESM
Sequence: MAGRELSHLQQLEAESIQIIREVAAEFDNPVMLYSIGKDSSVMLHLARKAFYPGKIPFPLLHVDTGWKFKEMIAFRDAQAKKFGFELLTHTNPEGVAQGINPFDHGSAKHTDIMKTQGLKQALNQYGFDAAFGGARRDEEKSRAKERVYSFRDRHHRWDPKNQRPELWRTYNGAVNKGESIRVFPLSNWTELDIWQYIYQENIELVPLYFAAERPVVERGGQLIMADDERMKLEEGETIKHEVVRFRTLGCYPLTAAMHSQADNLEKIIEEMLLTRSSERQGRLIDSDQSASMEQKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: TRUA_CHLT2
Sequence: MTKKIVLQIAYQGTSYSGWQYQPNALSIQEVLKTILKKIAGFRISVISSGRTDAGVHAQGQIAHFHCPDHPHFTDPRQIQKMLNALLPHDIVIRDAVMTDGDFHSRFSAIAKEYRYTLSLLPKPLPHHRLFCFSPRYKLNIARMQEAAQYLVGTHDFASFANLGREYSSTIRTLYTLDLSEQEHLVTVICRGNGFLYKMVRNIVGALLDIGKGKYPPEHLLDMLATKDRRKGPPSAPPYGLSLHHVCYPPPYQWFCKHEHNNSSEGK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: UBIJ_ECOLI
Sequence: MPFKPLVTAGIESLLNTFLYRSPALKTARSRLLGKVLRVEVKGFSTSLILVFSERQVDVLGEWAGDADCTVIAYASVLPKLRDRQQLTALIRSGELEVQGDIQVVQNFVALADLAEFDPAELLAPYTGDIAAEGISKAMRGGAKFLHHGIKRQQRYVAEAITEEWRMAPGPLEVAWFAEETAAVERAVDALTKRLEKLEAK
What is the function of this protein?
Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions (PubMed:24142253, PubMed:30686758).  Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex (PubMed:30686758).  May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates (PubMed:30686758).
What are the official names of this protein?
Ubiquinone biosynthesis accessory factor UbiJ.
What is the protein family that this protein belongs to?
Belongs to the UbiJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RING2_RAT
Sequence: MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVSICQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation.  H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.  May be involved in the initiation of both imprinted and random X inactivation.  Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.  E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4.  Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.  Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers.  Association with the chromosomal DNA is cell-cycle dependent.  In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.  Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase RING2, RING finger protein 1B, RING1b, RING finger protein 2, RING-type E3 ubiquitin transferase RING2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells.
Protein: LBR_MOUSE
Sequence: MPSRKFVEGEVVRGRWPGSSLYYEVEILSHDNKSQLYTVKYKDGTELELKESDIKPLKSFKQRKSGSISSSPSRRRGSRSRSRSRSRSRSPGRAPKGSRRSVSASHEGDVKEKKEKEMRREILQVKLTPLVLKPFGNSVSVYNGEPEHMEKNATPYKDKQERIILSTEDRYIVTQYSLRPRREEVKAKEIESEEQNLVTKGPAPLGTFQVTTPQRKDLEFGGVPGAVLIMLGLPACVLLLLLQCRQKDPGLLHFPPPLPALHELWEPRVCGVYLLWFFVQALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWGVELCYLYTHFLQLALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAFDLKFFCELRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEEALLTSMDIMHDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLSWPLASVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHLLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY
What is the function of this protein?
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:18785926).  Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (PubMed:22140257).  Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (PubMed:22140257).  Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity).
What are the official names of this protein?
Delta(14)-sterol reductase LBR, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, C14SR, Integral nuclear envelope inner membrane protein, Lamin-B receptor, Sterol C14-reductase.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Nucleus; nuclear rim.
Protein: HUTH1_CAEEL
Sequence: MRLQVQIGTECVVVPCKPDDTIHAVAKKSVEKLRRLRPKLPLADDYFEVRRTVGNSLLDPEDLVSDVLKDSDFIIVAASVEETEDAKEAKKQEEIDNARAEIEKIDNRRRKVSFADSLAPMVLAPPTKLLILDGNSLLPEDLVRCEKGECAIQLSMESEDRIRKARTFLEKIASEHRAVYGVTTGFGTFSNVTIPPEKLKKLQLNLIRSHATGYGEPLAPNRARMLLALRINILAKGHSGISVENIKKMIAAFNAFCVSYVPQQGTVGCSGDLCPLAHLALGLLGEGKMWSPTTGWQPADVVLKKNNLEPLELGPKEGLALINGTQMVTALGAYTLERAHNIARQADVIAALSLDVLKGTTRAYDPDIHRIRPHRGQNLSALRLRALLHSEANPSQIAESHRNCTKVQDAYTLRCVPQVHGVVHDTIEFVREIITTEMNSATDNPLVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPTFLTPDGGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALTVVEHVEAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVLEMIRENRIWEAVLPHLETLEAMEELDPDALRQFTKTPTGIVQDRSMIPISDDEESIE
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
Protein: DCTN2_CAEEL
Sequence: MSSIGKEDIYESDGAASQVQKSEPENDNPTHPDIELISVDVDEALKKYKNRVLNLTSSDFSDSIAKKRRHAFGNNQYVLEVTGAGFSGTETAAEKLNRILYEVADLNEQIRADENLKTDLLNAEVLENLEKEVKTLQVAQSNGKTARVEHDVELPNVRTDSKVATLENRLRRIEQVIGSSVIPSAPVLDTIEDLKLRCETLNHSYVSGLEQRLNMMLTKLEKIDETRANNDIDENLDKKVDEILELMQKWDVACSSLPSNVNKVKALNRLHEQVQHFAGGLSHLKTIREKLEKEVAQGREAIIEYESQGKQEIGSVVEKLKLLEAKVADLK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes (By similarity).
What are the official names of this protein?
Probable dynactin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
Protein: ESPC_ECO27
Sequence: MNKIYALKYCHATGGLIAVSELASRVMKKAARGSLLALFNLSLYGAFLSASQAAQLNIDNVWARDYLDLAQNKGVFKAGATNVSIQLKNGQTFNFPNVPIPDFSPASNKGATTSIGGAYSVTATHNGTTHHAISTQNWGQSSYKYIDRMTNGDFAVTRLDKFVVETTGVKNSVDFSLNSHDALERYGVEINGEKKIIGFRVGAGTTYTVQNGNTYSTGQVYNPLLLSASMFQLNWDNKRPYNNTTPFYNETTGGDSGSGFYLYDNVKKEWVMLGTLFGIASSGADVWSILNQYDENTVNGLKNKFTQKVQLNNNTMSLNSDSFTLAGNNTAVEKNNNNYKDLSFSGGGSINFDNDVNIGSGGLIFDAGHHYTVTGNNKTFKGAGLDIGDNTTVDWNVKGVVGDNLHKIGAGTLNVNVSQGNNLKTGDGLVVLNSANAFDNIYMASGHGVVKINHSAALNQNNDYRGIFFTENGGTLDLNGYDQSFNKIAATDIGALITNSAVQKAVLSVNNQSNYMYHGSVSGNTEINHQFDTQKNNSRLILDGNVDITNDINIKNSQLTMQGHATSHAVFREGGVTCMLPGVICEKDYVSGIQQQENSANKNNNTDYKTNNQVSSFEQPDWENRLFKFKTLNLINSDFIVGRNAIVVGDISANNSTLSLSGKDTKVHIDMYDGKNITGDGFGFRQDIKDGVSVSPESSSYFGNVTLNNHSLLDIGNKFTGGIEAYDSSVSVTSQNAVFDRVGSFVNSSLTLEKGAKLTAQGGIFSTGAVDVKENASLILTGTPSAQKQEYYSPVISTTEGINLGDKASLSVKNMGYLSSDIHAGTTAATINLGDGDAETDSPLFSSLMKGYNAVLSGNITGEQSTVNMNNALWYSDGNSTIGTLKSTGGRVELGGGKDFATLRVKELNANNATFLMHTNNSQADQLNVTNKLLGSNNTVLVDFLNKPASEMNVTLITAPKGSDEKTFTAGTQQIGFSNVTPVISTEKTDDATKWMLTGYQTVSDAGASKTATDFMASGYKSFLTEVNNLNKRMGDLRDTQGDAGVWARIMNGTGSADGGYSDNYTHVQIGADRKHELDGVDLFTGALLTYTDSNASSHAFSGKTKSVGGGLYASALFDSGAYFDLIGKYLHHDNQYTASFASLGTKDYSSHSWYAGAEVGYRYHLSEESWVEPQMELVYGSVSGKSFSWEDRGMALSMKDKDYNPLIGRTGVDVGRTFSGDDWKITARAGLGYQFDLLANGETVLRDASGEKRFEGEKDSRMLMNVGMNAEIKDNMRFGLELEKSAFGKYNVDNAINANFRYSF
What is the function of this protein?
Serine protease with enterotoxic and cytotoxic activities.  Cleaves fodrin, but does not cause its redistribution within epithelial cells.  The exact role of EspC in EPEC pathogenesis is still unknown.
What are the official names of this protein?
Serine protease EspC.
What are the subcellular locations of this protein?
[Serine protease EspC]: Periplasm. SUBCELLULAR LOCATION: [Secreted autotransporter protein EspC]: Secreted. Cell surface. SUBCELLULAR LOCATION: [Autotransporter protein EspC translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Protein: YGIC_ECO57
Sequence: MERVSITERPDWREKAHEYGFNFHTMYGEPYWCEDAYYKLTLAQVEKLEEVTAELHQMCLKVVEKVIASDELMTKFRIPKHTWSFVRQSWLTHQPSLYSRLDLAWDGTGEPKLLENNADTPTSLYEAAFFQWIWLEDQLNAGNLPEGSDQFNSLQEKLIDRFVELREQYGFQLLHLTCCRDTVEDRGTIQYLQDCATEAEIATEFLYIDDIGLGEKGQFTDLQDQVISNLFKLYPWEFMLREMFSTKLEDAGVRWLEPAWKSIISNKALLPLLWEMFPNHPNLLPAYFAEDDHPQMEKYVVKPIFSREGANVSIIENGKTIEAAEGPYGEEGMIVQQFHPLPKFGDSYMLIGSWLVNDQPAGIGIREDRALITQDMSRFYPHIFVE
What is the function of this protein?
May be a ligase forming an amide bond.  Shows ATPase activity (By similarity).
What are the official names of this protein?
Putative acid--amine ligase YgiC.
What is the protein family that this protein belongs to?
Belongs to the glutathionylspermidine synthase preATP-grasp family.
Protein: PFD2_ARATH
Sequence: MASKSGSGGLREPPNEQAVLNMYEGKRSELSQIYSNITDLEMQVSEHSLVINAIQPLDQSRKCFRMIGGVLVERTIKEVLPAVQRNKDGLEEVVRKLYETLEKKKKDLTEFEAKYKIRITKQEDNKEGGNKKEGNAQGVLVGAASSSQ
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it (PubMed:19825635).  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (PubMed:19825635).  Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (PubMed:32396196).  Required for microtubules (MTs) organization and dynamicity (By similarity).  Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus (By similarity).
What are the official names of this protein?
Prefoldin subunit 2, Gene involved in microtubule biogenesis 4.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (By similarity). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (By similarity). This changing subcellular localization follows a daily rhythm coordinated oscillation (By similarity).
Protein: TRUA_STRPD
Sequence: MVRYKATISYDGTLFSGFQRQRHLRTVQEEIEKTLYKLNNGTKIIIHGAGRTDAGVHAYGQVIHFDLPQEQEVEKLRFALDTQTPEDIDVVNIEKVADDFHCRYQKHLKTYEFLVDNGRPKNPMMRHYTTHYPYTLNIKLMQEAINGLVGTHDFTGFTAAGTSVQNKVRTITKATVSRDEKTDFLVFTFSGNGFLYKQVRNMVGTLLKIGNGQMPVEQVKVILSSKNRQLAGPTISGNGLYLKEICYEN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.