PharMolix/UniProtQA huggingface dataset:
Protein: HPM7_HYPSB
Sequence: MTRAILPDVSPDSIDPQFLEEKYDQERLKRINAAGYAKYSEVGDGELERFKVTHRLEDVASSREPVSVDTDVVIIGAGYAGILTAVRLVQNGILNFRIVEKGNGFGGTWYWNQYPGAQCDVESYIYMPLLEETGYVPTERYARGPEILKHINLIAKKWELAPKTHFQSEVSAADWTADRWTVKTRQGDEFRSRYLVTAIGPFHRPKLPGVPGINSFKGNTFHSSGWDYEASGGSATEKLTKFSDKTIGIIGTGATAVQMLPFVANSAKEVLVFQRTPAPVNVRNNGPTPPDFAKFLEPGWQLRRMDNFNKIYTGEPIDTSIVSEEWLSATLQVLFGTESDKPSDPAELEQLLARTDFQVMERIRRRVDETIKDPVTREQLKPWYATICKRPCFHDEYLECFNRPNVRLVDTDGKGVDRITEDSVVVDGKEHHVDALVFCTGFEYLSGVDRHGGFTVTGKDGVTLTERWTPGPSTYHGLYVHGFPNFFCLQTAQAGTNPNFMYTATTGSTQIGHVIAECLKDGVREVQPTKQAEDDWVKMILEGGRGMMHLMRNCTPGYMNNDGNLDEKTARRMFYPGGPTAWRKLLEAWREKGDFEGLQRTY
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690).  The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707).  The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707).  Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707).  The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690).  The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690).  The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690).  The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690).  The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690).  The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690).  The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A.  The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
What are the official names of this protein?
FAD-binding monooxygenase hmp7, FMO hmp7, Hypothemycin biosynthesis cluster protein hpm7.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: APHA_EDWI9
Sequence: MFITTKKSLIALVLATAGLISSPVSFATETGAQPNLGATLTQLTQQYPIHWISIEQVAESLKGKAPISVGFDIDDTLLFSSPAFFYGKQKFSPDSNAFLKNQKFWDAVSSSGWDRFSIPKDSGRALMELHLKRGDHVYFITGRPMPSNGKEDLTQTLKDDFKIPDNQLNKVIFAGTKQDAKVEYMQKYHITIFYGDSDNDIQDARKAGAEGIRVLRPLNSTNKPMPKNGAFGEKVIVNSQY
What is the function of this protein?
Dephosphorylates several organic phosphate monoesters.  Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).
What are the official names of this protein?
Class B acid phosphatase, CBAP.
What is the protein family that this protein belongs to?
Belongs to the class B bacterial acid phosphatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYD_DEIDV
Sequence: MKRTALIGQLSTTHLDQAVTLQGWVNRRRDLGGLIFLELRDRSGLVQVQVEPDSPAFAQADQLRAEYVAEVEGIYRARPENQRKGGAADYEVIASRVKVLNTAKTPPFELDKGESVAEDIRLKYRYLDLRRPEMQRHLLLRSRAMAAVTAFLDSSGFVQVETPMLTKSTPEGARDFLVPSRLNPGEFYALPQSPQLFKQLLMIAGYDRYYQFARCFRDEDLRADRQPDFTQLDMEMSFVEQDDVLELQEGLMAHVFKATLDVDLPRPFPRLSYFDAMDRYGSDKPDLRFESALVDVTDLFQGGEFKAFAAAQSVKVLAAAELTRKQIDELERVAKQNGAGGLAWLKRDGDSFTGGISKFVGSVAPQLIKRSGVQDGGTLLFAAGDWKKAVTALGAVRLAVRDLFDLTSSGPRFHVSWVTDFPQLEFDEDSGTWTYMHHPFTAPHPDDAELFGTLRQGEIRAQAYDLVLNGFEVGGGSVRIHDPAVQTKMFEAIGFTEAQAREKFGFFMDALEYGTPPHGGIAWGFDRLVMVMSGASSIREVIAFPKNNRGADLMAEAPSLVDDAQLAELGVGVLSPS
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMA_ECO57
Sequence: MNALLTNPFKERLRKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASQPVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTADQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRIKGSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: Y1590_LISW6
Sequence: MKISFHGQSCIKIITGNTTILVDPFISGNEKCDLKAEEQMPDFIVLSHGHDDHVGDTVEIAKNSGATVICNADLASFLAVEDGLENIAAMHIGGKRQFEFGQVKLTQAFHGSQTVRNGRIINLGFPTGVVFTIENKNIYFAGDTGLFSDMKLIGELNPLDVAFLPIGDNFTMGPEDAAIAARFLQTKLVIPMHYNTFPLIEQDPHKFVASLDEGISGKVLEIGESIEI
What are the official names of this protein?
UPF0173 metal-dependent hydrolase lwe1590.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: MIAA_CHLTB
Sequence: MSSSSSSGAATGFAVCSDPQKSFSKMFKRTVILLAGPTGSGKTAVSLKLAPLVDGEIISVDSMQVYQGMDIGTAKVSLADRKEVPHHLIDVCHVQESFNAVDFYYHAVQACQDILSRNKVPILVGGTGFYFHTFLSGPPSGPSPDFVLREQLTLEAQERGISALYQELELLDPVYAATITKHDKNKIIRALEIIRKTGSKVSSYAWQSTVNESKEYHCRGWLLSPDPELLRHNILERCDQMLEEGLLDEVQALLAAGIKGNSSASRAIGYREWIEFLDLGSPPDLFEITKQKFITNTWRYTKKQRTWFKRYSLFRELRPMGMTLDDMAKKIAQDYFLCG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FRDA_SCHPO
Sequence: MQSLRAAFRRRTPIFLKPYEFSTNVFGLRCRYYSQVRHNGALTDLEYHRVADDTLDVLNDTFEDLLEEVGKKDYDIQYANGVITLMLGEKGTYVINKQPPAHQIWLSSPVSGPKHYEYSLKSKTWCSTRDEGTLLGILSSEFSKWFSRPIEFKKSEDF
What is the function of this protein?
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways.  May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+).  May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).
What are the official names of this protein?
Frataxin homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EPG5_AEDAE
Sequence: MVPLSGEQLAQFYRVDGEMALAEAFEKEFLTRELQENDQCMNHPLYQLLQRYAKARAEFSLNVLEFEALRRKCKALANELWTVREQTFAGTGTCGDGKVVHASHISSVAALQESALADFSSNLQDLMKQSFFQCSQSTYEVDATRIKIEQKIYETLNLHPVLSNLPADSPVVLNPPIDAMQLTAAIGELRLCISILFAFLRKGITDKRFLADVRGWTVKLVATQLRIATVHDHLFVLFHVLRSPSGIANWATSLVQLPTEQDLRWGSSEFQHILVVMACILLPIKKRNEFLEKLKLDMNRSIDVVQEEMWAIVDSDGEDCSGSDSISELKEGDLVALIDQIPFGMVFRALTLVDRKLDGTWRLGEDQVRGTHVMKAIAFGTIFVELLGNGLMTYNADRYRQFAKRVARLIKHTVYYVSDLYRILLERTRSVQVVLDDYETTRINLELDVFVVRAAQYIYRSRKIGTWQYLSGFPFDQLSVGALWKLYYFLHLDEFNEELITAVGTDFRDLCIGPNQREKFRNGLVGMPSEDLYYLLQVFSNMALAREIDDFEFIETVALNLFDIGYLNEYTKDFCYKAVKDLLFNIVYKHPSLVSSLLQYMKQDVAQADHSALYVFKSLPLDRWRPQWDDFELLANWILNYGFDAVQSSTARVILIHLNYNFDSNNELFLPHDIHVRIACLITEIYSKHVPELLGNPQGLVASVSSLVKNKTAQDQFLAWCWNMVSLLRLHCMDQSPTVINGMMKNPALILRYVLELERAQQIYQGVTENRPLAIYLAILISTWGHSVPQICHQGFEQIRLLLNDHRYVVVVRCLQLITPLFLECPDSLSHCESFKSILISLMAADKYYARFTKDQFKPESNSPCLTELPNWTKDPAIIGLLDAMAGVAYQFPDAWHSMKEFFRPYFSVSSIILHSPSSATVFLSIFTLELEYELTEIQSGIWHEVIRGIGLPSSPKLTIETAIKKSTSILGYPSFPPSSLAVFKLANLVANCTIKNFMYPIVCQLFFTIYLSRLPLSTEEQRFANCFGVSDQIYECNVGLMKRIKKQLYDAECFYNSASVSESDERQRSFYNHCTRLFKTFQLWLEDTQLNKISTNAVNLPPQFDRYRLAAIFRGNRDHWTDFIDFRGIRSDHRDLADAWQKLCYRYKPEVSTVATNSPARSLASSHSVTDLQDFKQSIFKRLETYDAPAPAPLVFKPTPLIPPAKFTTQSSNSFLVMYNEHLLLDSFYLEQVPKLYIVEDKVLYKDASCSNGCTESRKVLVRYKVSKLDKNLSAVLRENRSAHEALLQRESKLPDRIVMASVRIDAFLRQIVEAYREFKLSGETNVCAKLNKVGSTLFYEFVGKMNDYNQLCPLTKDVCSLGISQLGFFMRENQNDEGIKLLNITLGRPEMISLLSELLVPASCPPQFFLRMYEFVIDSHIKRHDTQVLFVMLSKFDIIAWMNRYRPKLVDVRRLVELILRGLEGWTQKNAVLIQDLLQRHLMHLFEFDFPEYYGDILQMVLAACSLKKIMAQVLLELLNSMRRRVECQPLTFGLGLVSIKEDFRSFATKQKILSYKDLIDTTVLLTQHFQQERLNHGLHGLYPVHSDYCEVLSLLLGSVGHATVVAAVHAYPGVLADELINWLWPPLCDMFSPWLTPYFPQNMKGQQQVANWIQQVASDSSILPPWSELHSETAFRMVKVFEHCIQYLMDTFPSSSALLGHLFSWYELNFAHPALPRHVAVPIHTNLMNLAWDRFRPAPVHITGFSRILQQFIPEAHKFVGHIFIRIAWTPWLQQNIQSWDYQLRYQMLSALLMIFIKISYEPNAREGLKIVTLLQEACNYPWHMLEYQGVEAVLDWFVLSAEPSVVLKMPSESEVVDSAVLDLLQVASSMKFNSGNPLESTALQSQVQAKRILYVRTTVRLLNSCGAKYQKLLGTKQGVQAFHNAVLGLFNIVETVLLQIRSTKDREFEARNLIGEVIVSLQSQGEYTSKLFTEAIVLWTENCRTSDSYIVPSVLDAVGMCKSFSLNLYLLLEEMLFHYFGKSWHGQVNDGGDPVLDASWVKALHKVGLQTVKGFDEEMLVKHRCLLVLHLLTVQKLRTAGSSGERIVVLQKLFQLLENVKVSDQTESKLILLWSLMAVVGVEIMKASSNGQNHLLTLARYLQTCSKDAEGWGEGLLGAIGIRKDGISIRRKVVAKCLSCIVFLLFGEDSGEALEASESGPPSIDCANRCKEYDQAMGDLKQTLTNKRYGDMHIKTRAAINLVENTAMIANIGENVCKIVRLFCDEHFFHSVEEVWRC
What is the function of this protein?
Involved in autophagy.
What are the official names of this protein?
Ectopic P granules protein 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the EPG5 family.
Protein: HOPD_ECOLX
Sequence: MDATLPFLILYACLSVLLFLWDAKHGLLPDRFTCPLLWSGLLFSQVCNPDCLADALWGAIIGYGTFAVIYWGYRILRHKEGLGYGDVKFLAALGAWHTWTFLPRLVFLAASFACGAVVVGLLMRGKESLKNPLPFGPFLAAAGFVVGWDSLLAGR
What are the official names of this protein?
Leader peptidase HopD.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
Protein: RL24_METS4
Sequence: MAAKVKKGDKVVVLTGRDKGRTGEVIQVMPKENRALVRGVNLVKRHQRQTQTQEGGIISKEAAIDLSNLAVADPKDGKPTRVGFRILEDGRKVRFAKRSGDLIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: NADK2_PARMW
Sequence: MPRIGLIVNDGKPLAVQTADTIQQRLELAGHAVVRASSSGGMVGFANPDQHLRLLGYSACVPEGFNNSMALAIVLGGDGTVLSAARQTAPVGVPILTINTGHLGFLAEAYLGDLDRALEVVLTEQWTIEERSNLVVSVMRGDQRRWEALSLNEMALHREPLTSMCHFEIAIGRHAPVDIAADGVILSTPTGSTAYALSAGGPVISPDCPVLQLTPIAPHSLASRALVFSDREPVTVFPATPERLMMVVDGSAGCYVWPEDRVLIRRSEHPVRFVRLVDHEFFQVLRNKLGWGLPHIAKPDKG
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 2, ATP-dependent NAD kinase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHED_METMP
Sequence: MVLKVKMGDIGVAKSPESIETLLGSCVAIILYDRGKKIGGVAHVMLPKSRNSSEKNPGKYANTAIPELINRMAKLGARKDKLTTKLAGGAAMFKCNSNTIDVGKKNIEASREEVKKMGLRIASEDLGGDTGRTITLSLKDGSVLVRTGSELKTI
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: HIS3_NATPD
Sequence: MSVDLAFDEQELLPAVAQDAESGDVLMLAYVSEEAVARSRETGYAHYYSRSREELWKKGGSSGHTQEIEEIRVDCDGDAILYLVEQAGGACHTGYDTCFHRTLDGDIVGEQVFDPEEIYE
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_MYCBO
Sequence: MAMTPISQTPGLLAEAMVDLGAIEHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRADGITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDTGLNRNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQAREQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAVALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRRCPGVGRICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVTSPRGRITRTYREAENR
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: Y1681_STRA3
Sequence: MNTNTIKKVVATGIGAALFIIIGMLVNIPTPIPNTNIQLQYAVLALFAVIYGPGVGFFTGFIGHALKDSIQYGSPWWTWVLVSGLLGLMIGFFAKKLAIQLSGMTKKDLLLFNVVQVIANLIGWSVVAPYGDIFFYSEPASKVFAQGFLSSLVNSITIGVGGTLLLLAYAKSRPQKGSLSKD
What are the official names of this protein?
UPF0397 protein gbs1681.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1346_STRP1
Sequence: MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVNKNSGFGKVEAYHYLSSARNADVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKHSHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKIVEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMAEKLYQTAIAFSDLSKDDIVIDAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTESFIQASVAMGPQKITYVSCNPATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE
What are the official names of this protein?
Uncharacterized RNA methyltransferase SPy_1346/M5005_Spy1098.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: LIS1_XENTR
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSTISDATGSETKKSGKPGPFLLSGSRDKTIKMWDISIGMCLMTLVGHDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation (By similarity).  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  May be required for proliferation of neuronal precursors and neuronal migration.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: GATA_ACIBS
Sequence: MTDLHRLSIRELAKGLSQAKFSSRELTEHYLKRIAKIDPQVKSYVTVTPEQALCEADAADAALKAGNATALTGIPLAHKDIFCTKGIKTTAGSKMLDNFISPYDATVVEKTKAAGLVTLGKVNMDEFAMGSTSESSYVGATSNPWALDHVPGGSSGGSAAAVAADLAPFATGTDTGGSIRQPASFCGLTGLKPTYGRVSRFGIIAYASSLDQAGPMARSAEDCAYLMNVIAGHDAKDSTSVKKEVDDYVANLNNTSVKGLRIGIPKQYFNVAGLDAEVKARVEESLKKLEEMGAKLVEIDLNMTEAYVPTYYLIAPAEASSNLSRYDGVRYGYRCENPADLMDLYKRSRSEGFGPEVQRRILIGTYALSAGYYDAYYVKAQKVRRLIQQDFLKAFENVDVIAAPAAPTTAYKIGASLDPVEMYLGDIYTIAVNLAGLPAINAPVGFDKDNLPVGLQLIGNYWSESQLLSIVHQYQQNTDWHTKRAAIAEENA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: GPN3_XENTR
Sequence: MPRYAQLVMGPAGSGKSTYCSTMVQHCGSLNRSVQVVNLDPAAEHFDYPVLADIRELIEVDDVMEDRSLRFGPNGGLVYCMEYFANNFDWLESCLGHTEDDYILFDCPGQIELYTHLPVMKYLVEQLQQWEFRVCGVFLVDSQFMVESFKFLSGVLAALSAMVSLEIPQCNIMTKMDLLGKKAKKEIEKFLDPDMYSMIEDTSNRFKSNKFKKLTEALCGLIDDYSMVRFLPFDRSDEECMNIVLQHIDFAIQYGEDLEFKEPKENEEDKSENFDEFFQDRADEP
What is the function of this protein?
Small GTPase required for proper localization of RNA polymerase II (RNAPII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 3, ATP-binding domain 1 family member C.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: KT222_MOUSE
Sequence: MELSQLLNEIRANYEQLLTRNQIETVLSTRIQLEEDITKKMDKDGEALKAAQAELKEARRQCHHLQVEIESLHAVERGLENSLQASEQHYQMQLQDLESVIGRLERELQEVRRGIERQLREHEMLLNTKMRLEQEIATYRRLLEQEEIRYYGCIQGEKKEEKPTKSKVGFLLPSAIINEISFSTKVSQKYENENMETVTKQAVVNRDVKESAEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLESRQDNLPDIEVRLIMRRSCSIPSIKPPPGTN
What are the official names of this protein?
Keratin-like protein KRT222, Keratin-222.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: MOAC_THISH
Sequence: MSTLTHFNAKGEAHMVDVGDKSVTHRVAVAEGHITMEPETLALIRSGTHKKGDVLGIARVAGIMASKKTSELVPLCHPISLTHVEVELSTADSPPSVHCRVTAETRGQTGVEMEALTAVQVALLTVYDMCKAVDRFMTMGGVRLVHKSGGKSGTWDLKGSG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: OPSD_MYRBE
Sequence: TEGPYFYIPMSNATGVVRSPYEYPQYYLVYPAAFAVLGAYMFFLIIFGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVIGGFTTTIYTSMHGYFVLGRLGCNLEGFSATLGGMISLWSLVVLAVERWVVVCKPMSNFRFGENHAIMGVTLTWAMGLACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFVCHFSFPLVVIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVIGFLVCWLPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSAIYNPVIYICLNKQFRQCMLTTLFCGKNPFEEEEGASSTKTEASSASSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: TPC2L_BOVIN
Sequence: MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQVC
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 2-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. Sedlin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.
Protein: SP5G_PHYAS
Sequence: MKVTDVKIRKINGESRLRGVASIAFDDCFVVNDIRIIEGEKGIFIAMPSRKTTKGTFRDIAHPVNTETRQVIEESILTKYQDVLNNPVEDKPEQEN
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: SC23A_BOVIN
Sequence: MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGPQVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKTCCVKCCLMC
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.  Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
What are the official names of this protein?
Protein transport protein Sec23A, SEC23-related protein A.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Note=Enriched at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).