PharMolix/UniProtQA huggingface dataset:
Protein: NR2C2_MOUSE
Sequence: MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
What is the function of this protein?
Orphan nuclear receptor that can act as a repressor or activator of transcription.  An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways.  May regulate gene expression during the late phase of spermatogenesis.  Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity).  Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1.  Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences.  Plays a fundamental role in early embryonic development and embryonic stem cells.  Required for normal spermatogenesis and cerebellum development.  Appears to be important for neurodevelopmentally regulated behavior.
What are the official names of this protein?
Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPS_PSEAB
Sequence: MHAPSQIRLTFNQDHPEPHEHEDEGAGLAVQESKPVLQPPPLYKVVLFNDDYTPMDFVVEVLEVFFNMDREKATKIMLTVHTQGKAVCGLFTRDVAETKAMQVNQYARESQHPLLCEIEKDS
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: TLCC_RICPR
Sequence: MLPPKIFFEKVKEIIWPIERKELKLFIPMALMMLCILFNFGALRSIKDSLVVPSMGAEIISFLKLWLVLPSCVIFTILYVKLSNKLNFEYIFYSIVGTFLLFFLLFAYIIYPNQDIYHPNDAMINNLIASYPNLKWFIKIGSKWSYALMYIFSELWSAVVINLMFWQFANHIFDTAKAKRFYPVLGMVGNIGLIIAGSVLVFFSSGQYIIDSELLTDSYNSSSNNSIMLQPIISIIVTAGIIAMFLFRIINKFILTNSINVLDVKKVAAKTKTKLALIESIKLIIHSKYIGRIALLIICYGLLINIVEGPWKAKIKELHPNTVDYVNFMGMFNIWMGISCVTFMIIGSNILRRLGWLISALLTPIMLSITGFMFFIFIIFIEEIGTCFGDFNLLYVAIIVGAIQNILSKSSKYSLFDSTKEMAYIPLSLELRTKGKAAVEVIGTKFGKSLGAFIQSLIFIIIPTATFDSIIIYLLVIFIVMMNLWIWNIIKLNKEYIKLCQ
What is the function of this protein?
Provides the rickettsial cell with host ATP in exchange for rickettsial ADP.  This is an obligate exchange system.  This energy acquiring activity is an important component of rickettsial parasitism.
What are the official names of this protein?
ADP,ATP carrier protein 3, ADP/ATP translocase 3.
What is the protein family that this protein belongs to?
Belongs to the ADP/ATP translocase tlc family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTU2_DESPS
Sequence: MSKEKFERTKPHVNVGTIGHIDHGKTTLTAAITRVLSTKGQASFTDFSDIDKAPEEKERGITIATAHVEYETVNRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGAMPQTREHILLARQVGVPAMVVFLNKCDMVDDDELIELVEMELRELLDDYEFPGDDVPFIHGSALLALENPEDEDKAACIWALMEAIDSYIPEPERDVDQPFLMPVEDVFSISGRGTVATGRVERGIIKVGEEVAIVGVKDTVKTTCTGVEMFRKLLDEGRAGDNIGALLRGVKREDIERGQVLAKPGTITPHTKFKAECYILGKDEGGRHTPFFNGYRPQFYFRTTDVTGVVSLPEGIEMVMPGDNVSVDATLITPIAMDAGLRFAIREGGRTVGAGVISEIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_MAGSA
Sequence: MAVLVLASASPRRLDLLRQIAIMPGLVDPAHVDETPLKGELPVPHARRLAEAKALAVAGRHPGAFVLAADTVVACGRRILPKAEDEATARQCLELLSGRRHRVVGGICLIAPDGRIGRRTVTTSVTFKRLSHAEMAAYAASGEWDGKAGGYAIQGLAARYVRDIQGSYSNIVGLSLFETAQLLDGFGFAP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PSEPW
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQKICADAGVNPAAKIKDLSDEQIETLRGEVAKFTTEGDLRRDVNMKIKRLMDLGCYRGLRHRKGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: Y031_HELPY
Sequence: MNILFGISDTQECYNAIKFAVKLAHSLKEVRFTLLHVSMEVFIYSESGMMDYGQTEALEEEKAKALLKQFEDAFKKENIECESVLKSGDLIDVVLDMAKDYDLLLIGASESNLLYRLFISHQNSLVEQSSIPVVIAK
What are the official names of this protein?
Universal stress protein HP_0031, USP HP_0031.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
Protein: UPP_CLOB1
Sequence: MSKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPICKTKCKMLSGKKVAIVPILRAGLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQDIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCLVAAPEGIKEVMDEHPDVDIYVASVDEKLNEKGYVVPGLGDAGDRLYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: NS1_INBMD
Sequence: MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKNSSTSNCPNCNWTDYPPTPGKCLDDIEEEPENVDDPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLAIKRDIRNVVSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERFDEGHSKPIRAAETAVGVLSQFGQEHRLSPEEGDN
What is the function of this protein?
Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins.  Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response.  Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR.  Also binds poly(A) and U6 snRNA.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza B viruses NS1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: AROB_LACLM
Sequence: MKLNVNLPDHPYDVIIENGALANIGNWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKSGFEVETFEFPEGEASKNLLTAEKAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMRGIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQPDGVLIDPEVLKTLGQREFCEGLGEVIKCALIADKDLWNLLTDLSAKDLLENFAKIEEIIYRSCEVKRKVVVDDELDNGVRLYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAEKKGLMPLGITDEIRKMVKKYGLPDDYQPWDEALLFKALTHDKKARGTIIKTVIVPEIGTAKINEVTFEEMKEYLKK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAW1_XENTR
Sequence: MRLKRFLLRYFPPGIILEYEKGGELKTKAIDLLELSPTTDVDLVVEEIQKAEPLITASRTQQVKQLILRLQEKIGQQDSRQFYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRIHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLWNPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIWR
What is the function of this protein?
May play a role in axonemal outer row dynein assembly.
What are the official names of this protein?
Dynein assembly factor with WDR repeat domains 1, Outer row dynein assembly protein 16 homolog, WD repeat-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR69 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: CRCB_SPHAL
Sequence: MNSLFPVMVGGAVGAGARHLVGQAMLARFGPGFPWWTLSVNIVGSLAMGLLIGLLARSGTGGETTRLFVGVGMLGGFTTFSSFSMEFWLLFERGQSVQAGLYVVASVVGALLACGAGMILIRQLPA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CZS3_CRUCA
Sequence: KRGFLDVVKHIGKAALGAVTHLINQGEQ
What is the function of this protein?
Has antimicrobial activity against Gram-negative bacterium E. coli (MIC=13. 32 uM), aginst Gram-positive bacterium S. aureus (MIC=13. 32 uM) and against fungus C. albicans (MIC=13. 32 uM).  At higher concentrations also has a bactericidal and fungicidal effect.  Has hemagglutinating activity against horse erythrocytes.
What are the official names of this protein?
Cruzioseptin-3, CZS-3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Cruzioseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TIP44_MAIZE
Sequence: MAKFALGHHREASDAGCVRAVLAELILTFLFVFAGVGSAMATGKLAGGGGDTVVGLTAVALAHTLVVAVMVSAGLHVSGGHINPAVTLGLAATGRITLFRSALYVAAQLLGSTLACLLLAFLAVADSGVPVHALGAGVGALRGVLMEAVLTFSLLFAVYATVVDPRRAVGGMGPLLVGLVVGANVLAGGPFSGASMNPARSFGPALVAGVWADHWVYWVGPLIGGPLAGLVYDGLFMAQGGHEPLPRDDTDF
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Aquaporin TIP4-4, Tonoplast intrinsic protein 4-4, ZmTIP4-4, ZmTIP4;4.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: YKZD_BACSU
Sequence: MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTTE
What are the official names of this protein?
Uncharacterized protein YkzD.
Protein: LEU3_KODOH
Sequence: MSTKTITVVPGDHVGTEICDEAIKVLKAIEKVSPVKFEFKHHLIGGAAIDATGVPLPDETLEAAKSSDAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFVSDSLLELSPLKSEIVKGTNFTVVRELVGGIYFGERQEQEESSDGQSAWDTEKYSVEEVTRITRMAAFMALQHNPPLPIWSLDKANVLALSRLWRKTVDHVMSTEFPQLKVQHQLIDSAAMILVKSPSQLNGVIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLPANKVNPVATILSVAMMLRLSLDCLKEAEALEKAVGQVLDAGIRTADLRGSSSTKEVGDAVAAAVEKILAEGK
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7A_RAT
Sequence: MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L7a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_CHRVO
Sequence: MRDEDLVVMGFVRGAFGIKGWVKIHADTEYADGLFDYPTWWLGKNGSWKPYAFENGAVQPKALAAKLEGVDDRDAAEALRGTQIAIPRSELPEAGDGEYYWADLIGLSVVNQQGETLGKVDSLLETGANDVLVVKGGDGQQRLIPFVDQYVLEVVPAEGRILVDWGLDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTR_ECOL6
Sequence: MTQGAVKTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKEYIRLKLEVSRDYPQASRLFCMEMLAGAPLLMDELTGDLKALIDEKSALIAGWVKSGKLAPIDPQHLIFMIWASTQHYADFAPQVEAVTGATLRDEVFFNQTVENVQRIIIEGIRPR
What is the function of this protein?
Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines.  It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX) (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator RutR, Rut operon repressor.
Protein: DDL_TRIV2
Sequence: MSKLRVGLLFGGRSGEHEVSISSARAIASALSAGENASKYEILPFYIHKDGRWLAGEAPQQVLKSGAPLLESSNSSPADNNLVNSQQQTLERWQSPSQVAEVDVWFPILHGPNGEDGTIQGLLTLMQTPFVGSGVLGSALGMDKIAMKMAFEQAGLPQVKYKAVTRAQIWSNPCVFPKLCDEIEASLGYPCFVKPANLGSSVGISKVRSRQELEDALDNAANYDRRIIVEAGVVAREVECAVLGNDQPQASTVGEITFNSDFYDYETKYTAGKADLLIPAVIPDEISRQIQDMALQAFAAVDAAGLARVDFFYVEATGEVLINEINTLPGFTATSMYPQLWAYSGIPFPELVDKLVQLAIERHNPSH
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDKA_PONAB
Sequence: MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.  Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression.  Required for neural development including neural patterning and cell fate determination.  During GZMA-mediated cell death, works in concert with TREX1.  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase A, NDK A, NDP kinase A.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COXX_BACC3
Sequence: MNHATSELHDESAVTSIPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVLDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HDT3_MAIZE
Sequence: MEFWGLEVKPGSTVKCEPGYGFVLHLSQAALGESKKSDNALMYVKIDDQKLAIGTLSVDKNPHIQFDLIFDKEFELSHTSKTTSVFFTGYKVEQPFEEDEMDLDSEDEDEELNVPAVKENGKADEKKQKSQEKAVAAPSKSSPDSKKSKDDDDSDEDETDDSDEDETDDSDEGLSPEEGDDDSSDEDDTSDDEEEDTPTPKKPEVGKKRAAESSVLKTPLSDKKAKVATPSSQKTGGKKGAAVHVATPHPAKGKTIVNNDKSVKSPKSAPKSGVPCKSCSKSFISETAPQAHSKAKHGGK
What is the function of this protein?
Mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
What are the official names of this protein?
Histone deacetylase HDT3, Histone deacetylase 2c, HD2c, Zm-HD2c.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase HD2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HEM3_MANSM
Sequence: MNNKNHLKIATRQSPLALWQANYVKDRLTALYPDLQVELVTMVTKGDVILDTPLAKIGGKGLFVKELEHALLNHEADIAVHSMKDVPMEFPQGLGLSVICKREDPRDAFVSNKYRSLAELPQGAIVGTSSLRRQCQLKSLRPDLDIRSLRGNVGTRLSKLDNGDYDAIILASAGLIRLGMAERIASFIETDISLPAAGQGAVGIECRVDDELVQSLLAPLAHQETTICVLAERAMNNRLQGGCQVPIGGFAQVKNGEVFLRALVGATDGSQIIRAEGKSAVENAEVLGVQIAEDLLQQGADKILKSVYQD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TBA5_ARATH
Sequence: MREIISIHIGQAGIQVGNSCWELYCLEHGIQPDGMMPSDTTVGVAHDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLDRVRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDITEFQTNLVPYPRIHFMLSSYAPVISAAKAYHEQLSVPEITNAVFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVGTIKTKRTVQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGGDDEEDEGEDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-5 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SPIKE_CVHN2
Sequence: MFLIIFILPTTLAVIGDFNCTNSFINDYNKTIPRISEDVVDVSLGLGTYYVLNRVYLNTTLLFTGYFPKSGANFRDLALKGSKYLSTLWYKPPFLSDFNNGIFSKVKNTKLYVNNTLYSEFSTIVIGSVFVNTSYTIVVQPHNGILEITACQYTMCEYPHTVCKSKGSIRNESWHIDSSEPLCLFKKNFTYNVSADWLYFHFYQERGVFYAYYADVGMPTTFLFSLYLGTILSHYYVMPLTCKAISSNTDNETLEYWVTPLSRRQYLLNFDEHGVITNAVDCSSSFLSEIQCKTQSFAPNTGVYDLSGFTVKPVATVYRRIPNLPDCDIDNWLNNVSVPSPLNWERRIFSNCNFNLSTLLRLVHVDSFSCNNLDKSKIFGSCFNSITVDKFAIPNRRRDDLQLGSSGFLQSSNYKIDISSSSCQLYYSLPLVNVTINNFNPSSWNRRYGFGSFNVSSYDVVYSDHCFSVNSDFCPCADPSVVNSCVKSKPLSAICPAGTKYRHCDLDTTLYVNNWCRCSCLPDPISTYSPNTCPQKKVVVGIGEHCPGLGINEEKCGTQLNHSSCSCSPDAFLGWSFDSCISNNRCNIFSNFIFNGINSGTTCSNDLLYSNTEVSTGVCVNYDLYGITGQGIFKEVSAAYYNNWQNLLYDSNGNIIGFKDFLTNKTYTILPCYSGRVSAAFYQNSSSPALLYRNLKCSYVLNNISFISQPFYFDSYLGCVLNAVNLTSYSVSSCDLRMGSGFCIDYALPSSRRKRRGISSPYRFVTFEPFNVSFVNDSVETVGGLFEIQIPTNFTIAGHEEFIQTSSPKVTIDCSAFVCSNYAACHDLLSEYGTFCDNINSILNEVNDLLDITQLQVANALMQGVTLSSNLNTNLHSDVDNIDFKSLLGCLGSQCGSSSRSLLEDLLFNKVKLSDVGFVEAYNNCTGGSEIRDLLCVQSFNGIKVLPPILSETQISGYTTAATVAAMFPPWSAAAGVPFSLNVQYRINGLGVTMDVLNKNQKLIANAFNKALLSIQNGFTATNSALAKIQSVVNANAQALNSLLQQLFNKFGAISSSLQEILSRLDNLEAQVQIDRLINGRLTALNAYVSQQLSDITLIKAGASRAIEKVNECVKSQSPRINFCGNGNHILSLVQNAPYGLLFIHFSYKPTSFKTVLVSPGLCLSGDRGIAPKQGYFIKQNDSWMFTGSSYYYPEPISDKNVVFMNSCSVNFTKAPFIYLNNSIPNLSDFEAEFSLWFKNHTSIAPNLTFNSHINATFLDLYYEMNVIQESIKSLNSSFINLKEIGTYEMYVKWPWYIWLLIVILFIIFLMILFFICCCTGCGSACFSKCHNCCDEYGGHNDFVIKASHDD
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: GDF9_SHEEP
Sequence: MALPNKFFLWFCCFAWLCFPISLDSLPSRGEAQIVARTALESEAETWSLLNHLGGRHRPGLLSPLLEVLYDGHGEPPRLQPDDRALRYMKRLYKAYATKEGTPKSNRRHLYNTVRLFTPCAQHKQAPGDLAAGTFPSVDLLFNLDRVTVVEHLFKSVLLYTFNNSISFPFPVKCICNLVIKEPEFSSKTLPRAPYSFTYNSQFEFRKKYKWMEIDVTAPLEPLVASHKRNIHMSVNFTCAEDQLQHPSARDSLFNMTLLVAPSLLLYLNDTSAQAFHRWHSLHPKRKPSQGPDQKRGLSAYPVGEEAAEGVRSSRHRRDQESASSELKKPLVPASVNLSEYFKQFLFPQNECELHDFRLSFSQLKWDNWIVAPHKYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIHEKLDSSVPRPSCVPAKYSPLSVLAIEPDGSIAYKEYEDMIATKCTCR
What is the function of this protein?
Required for ovarian folliculogenesis.
What are the official names of this protein?
Growth/differentiation factor 9, GDF-9.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.