PharMolix/UniProtQA huggingface dataset:
Protein: ASNA_ECOLC
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S26A5_HUMAN
Sequence: MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA
What is the function of this protein?
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.  Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates.  It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate.  After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage.  They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization.  As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane.  The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state).  So, it acts as an incomplete transporter.  It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space.  Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
What are the official names of this protein?
Prestin, Solute carrier family 26 member 5.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Lateral wall of outer hair cells.
Protein: MSRB_ECO24
Sequence: MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: SUCR1_MOUSE
Sequence: MAQNLSCENWLATEAILNKYYLSAFYAIEFIFGLLGNVTVVFGYLFCMKNWNSSNVYLFNLSISDFAFLCTLPILIKSYANDKGTYGDVLCISNRYVLHTNLYTSILFLTFISMDRYLLMKYPFREHFLQKKEFAILISLAVWALVTLEVLPMLTFINSVPKEEGSNCIDYASSGNPEHNLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKRRSQQQATALPLDKPQRLVVLAVVIFSILFTPYHIMRNLRIASRLDSWPQGCTQKAIKSIYTLTRPLAFLNSAINPIFYFLMGDHYREMLISKFRQYFKSLTSFRT
What is the function of this protein?
Receptor for succinate.
What are the official names of this protein?
Succinate receptor 1, G-protein coupled receptor 91.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NS1_MPV15
Sequence: MGCNVMMELDYGGRAAWLAFHITNFDRSDLETILRGARVCNTWQDQRLSVYLVGRDCNLLRPFVQAAKFIHNTRRGQTLTHWFTKNIVFSSTGQETEPPIDPTCELLVELISG
What is the function of this protein?
May play a minor role in antagonizing the type I IFN-mediated antiviral response (Probable).  Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication (By similarity).
What are the official names of this protein?
Non-structural protein 1, Non-structural protein 1C.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Note=Most NS1 resides in the mitochondria as a heteromer with NS2.
Protein: AROA_ACIF2
Sequence: MTRYLVRPGSRLAGRFPVPGDKSISHRAVILGALAEGVTEVEGLLEGADVLATIAAFRSMGVQMEGPDKGHLRIHGAGLQGLRAPVVPLDCGNSGTAMRLLAGVLAGQPFPSTLVGDASLQKRPMGRILNPLRAMGAEIAAQDGRAPLHIHGRPLHGIDYALPVASAQVKSAVLLAGLYADGQTCVTEPAPTRDHSERMLQGFGQPVERHGPRACLRGGGRLCGQALQVPGDISSAAFFLLGATIAPGSDLTLEGVGINPTRTGIIEILTRMGARIDLTALREVGGEPVADIRVRYAPLQGIAIPPRLVPLAIDEFPALFIAAACAKGQTVITGAEELRVKESDRIAVMAGGLRALGATVEERVDGAIISGSALLGGRVDSHGDHRIAMAFAMAALVAQGDMEILDCANVATSFPSFPALAQQAGLLLEVASA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TP1B_MALDO
Sequence: NTVWPGTLTGDQKPQLSLTAFELASKASQSVDAPSPWSGRFWGRTRCSTDAAGKFSCETADCGSGQVACNGAGAVPPATLVEITIAANGGQDYYDVSLVDGFNLPMSVAPQGGTGECKPSSCPANVNMACPAQLQVKAADGSVISCKSACLAFGDSKYCCTPPNDTPETCPPTEYSEIFEKQCPQAYSYAYDDKNSTFTCSGGPDYVITFCP
What are the official names of this protein?
Thaumatin-like protein 1b, Pathogenesis-related protein 5b, PR-5b.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KV06_RABIT
Sequence: DVVMTQTPASVSEPVGGTVTIKCQASQSIYSNLAWYQZKPGQPPKLLIYKASTLESGVPSRFKGSGSGTDFTLTISDLECADAATYFCQGSBYTGTVFGGGTEVVVKG
What are the official names of this protein?
Ig kappa chain V region BS-5.
Protein: FABPL_EPICO
Sequence: MLFSGKYQLESQENFEAFRKAIGLPDELIQKGKDIKSISEIEENGDDFKVTITTGSKVIVNTFTVGKEAELETLTGEKAKGVVHRDGNKLKVSLKGIESVTELVDGNTIANTMTLGNIGYKRISKRV
What are the official names of this protein?
Fatty acid-binding protein, liver-type, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2AE_TRIST
Sequence: NLMQFETLIMKVAGRSGVWYYGS
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows a moderate inhibition of ADP-induced human platelet aggregation when tested on platelet rich plasma.  Exhibits high hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 Ts-A5, svPLA2, CTs-A5, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TAAR6_RAT
Sequence: MGSNSSPPAVLQLCYENVNGSCVKTPYSPGPRVLLYAVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFWVGVSVMPFSMVRSIESCWYFGRSFCTFHTCCDVAFCYSSLFHLSFISIDRYIAVTDPLVYPTKFTVSVSGICISISWILPLAYSGAVFYTGVYADGLEEVSDAVNCVGGCQVVVNQNWVLIDFLSFLIPTLVMIILYGNIFLVARQQAKKIETVGNKAESSSESYKARVARRERKAAKTLGITVVAFMISWLPYSIDSLVDAFMGFITPAYIYEICVWCAYYNSAMNPLIYALFYPWFKKAIKVIMSGQVFKNSSATMNLFSEQI
What is the function of this protein?
Orphan receptor.  Could be a receptor for trace amines.  Trace amines are biogenic amines present in very low levels in mammalian tissues.  Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.  Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
What are the official names of this protein?
Trace amine-associated receptor 6, TaR-6, Trace amine receptor 6, Trace amine receptor 4, TaR-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CALCA_MOUSE
Sequence: MGFLKFSPFLVVSILLLYQACSLQAVPLRSILESSPGMATLSEEEVRLLAALVQDYMQMKARELEQEEEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFGRRRRDLQA
What is the function of this protein?
CGRP induces vasodilation.  It dilates a variety of vessels including the coronary, cerebral and systemic vasculature.  Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.  It also elevates platelet cAMP (By similarity).
What are the official names of this protein?
Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LE06_BIOGL
Sequence: FFTTFDKDNDDQQNDN
What is the function of this protein?
Binds and precipitates antigens of the parasite Echinostoma paraensei.
What are the official names of this protein?
Hemolymph 65 kDa lectin BG06.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU1_NITHX
Sequence: MTSANKSDKDRVVIFDTTLRDGEQCPGATMTFEEKLEVAEMLDDMGIDIIEAGFPIASVGDFEAVAEIAKNAKNAVIAGLARAIPGDIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAEVLEIITATVTQARNLVEDVEWSAMDATRTPIDYLCKCVETAIAAGATTVNLPDTVGYAVPDEYRRMFRTIRERVPNADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGERAGNAALEEVVMAIKTRGDVMPYWCNVESTMLTRASKLVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQDAFVRFKALADRKKDIYDEDIVALVDEEMAASHDRIKLTSLTVIAGTHGPQRATMKLTVDGQTRIEEAEGNGPVDAVFNCIKRLVPHEAKLDLYQVHAVTHGTDAQAEVSVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQRDVPSAAAAS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: DUT_SHEHH
Sequence: MKTPIELKILDSRIGTEFPLPAYATPGSAGMDLRAITDTQLVIQPGETVLIPTGIAIHVADPSLAAIILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGSEPFTIEIGDRLAQLVFVPVVQAEFKLVDEFNQSDRGTGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RF3_LISMO
Sequence: MSQDLQKEVASRKTFAIISHPDAGKTTITEQLLLFGGVIRSAGTVKGKKSGKFATSDWMEIEKQRGISVTSSVMQFDYNGSRINILDTPGHSDFSEDTYRTLMAVDSAVMVIDAAKGIEAQTLKLFKVCRMRGIPIFTFINKMDRQGKMPLELLAELEEVLGIESYPMNWPIGMGKELAGLYDRYHRVIEQYRSEEDERFLPLGEDGDLKEAHAIQKSLYYDQALEEIMLLDEAGNDFSRERIIAGEQTPVFFGSALTNFGVETFLRTFVDFAPAPSSHESNEGVIEADNPKFSGFIFKIQANMNPAHRDRIAFIRICSGEFERGMNVTLTRTGKSLKLANSTQFMADDRETVNRAVAGDIIGLYDTGNYQIGDTITNGSKKLEFEKLPQFTPELFMRVYAKNVMKQKHFHKGVEQLVQEGAIQLFKTWRTEEYIIGAVGQLQFEVFEHRMRGEYNSEIRMEPIGKKIARWVKEEDADEKLSTARSMLVKDRFDQPLFLFENEFAINWFNDKNPDIELTSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL3_SAGOE
Sequence: MSHLPILLLLLLVSPGLQAAPTQTTSLKATQVNCSNLREEIVTLLNQPPLPSSNFNNLNREDQRILMKPNLRRPNLEAFQKAVKSLQNATAIESSLKDLPLCLPMATNASMQHPIRIKDGDWNDFRMKLKFYLKTLEIKQPQ
What is the function of this protein?
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
What are the official names of this protein?
Interleukin-3, IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor.
What is the protein family that this protein belongs to?
Belongs to the IL-3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NEUFC_DROME
Sequence: MFGLLRHLFKFQFLFVVAAVLGGIYHTEIRQFLRRQTDNYLDQAGQDASIPLAFQAGDDIGTLFTPAELAKFNGEEEGRPLYLALLGSVFDVSRGIKHYGSGCSYNFFVGRDASVSFISGDFETYDPETADDVLTLKPDDLIGLAGWRDFYQKDYVYKGRVIGRFYDEKGALTTYHHKFLELLEQARDAKRQVEELRARYPGCNIEWSEERGTRVWCTTTSGDGKERSWIGYPRKLYSRGNKSFQCACVPDAELDEIDAGGKVAHGDAMLKPYDNCEPQARECFYRV
What is the function of this protein?
Heme-binding protein.
What are the official names of this protein?
Neuferricin homolog, Cytochrome b5 domain-containing protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family. MAPR subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAK_LACAC
Sequence: MSKVIGIDLGTTNSAVAVLEGKEPKIITNPEGNRTTPSVVAFKDGEIQVGEVAKRQAITNPNTIVSIKRHMGEADYKVKVGDKSYTPQEISAFILQYIKKFSEDYLGEEVKDAVITVPAYFNDAQRQATKDAGKIAGLNVQRIINEPTASALAYGLDKDDDDEKVLVYDLGGGTFDVSVLQLGDGVFQVLSTNGDTHLGGDDFDNRIMDWLIKNFKDENGVDLSKDKMAMQRLKDASEKAKKDLSGVSSTHISLPFISAGESGPLHLEADLTRAKFDELTNDLVEKTKIPFDNALKDAGLTVNDIDKVILNGGSTRIPAVQKAVKEWAGKEPDHSINPDEAVALGAAIQGGVISGDVKDIVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQIFSTAADNQPAVDVHVLQGERPMAADDKTLGRFELTDIPPAPRGVPQIQVTFDIDKNGIVNVSAKDMGTGKEQKITIKSSSGLSDEEIKRMQKDAEEHAEEDKKRKDEADLRNEVDQLIFTTEKTLKETKGKVSDEDTKKVQEALDDLKKAQKDNNLDEMKEKKDALSKAAQDLAVKLYQQNGGAQGAAGQAGPQGGNPNDGNNGGAQDGEFHKVDPNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HEMA_I74A2
Sequence: MKTIIVLSYFFCLALSQDYSESNNSTATLCLGHHAVPNGTIVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGRDCTLIDALLGDPHCDVFQDETWDLYVERSSAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPASGFFSRLNWLTKSGSTYPVLNVTMPNDDNFDKLYVWGVHHPSTNQEQTDLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSGRISIYWTIVKPGDVLVINSNGNLIAPRGYFKIRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQSTLKLATGMRNVPEKKTRGLFVAIAGFIENGWEGMIDCWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLENYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFERTRRQLRENAEDMGSGCFKIYHKCDNACIESIRNGTYDHDIYRDEALNNRFQIKGVELKSGYKDWILWISFATSCFLLCVVLGGFIMWACQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: ASM3B_MOUSE
Sequence: MTLLGWLIFLAPWGVAGAQLGRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRYYVYNSVSYNHLTCEDSCRIEHVCAIQHVAFNTYATCLHGLGAKLVPGFLLILTLLPSLHVLEVL
What is the function of this protein?
Lipid-modulating phosphodiesterase.  Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358).  Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724).  Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724).  Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724).
What are the official names of this protein?
Acid sphingomyelinase-like phosphodiesterase 3b, ASM-like phosphodiesterase 3b.
What is the protein family that this protein belongs to?
Belongs to the acid sphingomyelinase family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Lipid- anchor, GPI-anchor.
Protein: RL39_SPOFR
Sequence: MSAHKTFIIKRKLAKKLKQNRPIPQWVRMRTGNTIRYNAKRRHWRRTKLKL
What are the official names of this protein?
60S ribosomal protein L39.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: NRX1B_HUMAN
Sequence: MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
What is the function of this protein?
Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins.  Plays a role in formation of synaptic junctions.
What are the official names of this protein?
Neurexin-1-beta, Neurexin I-beta.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Single-pass type I membrane protein.
Protein: FABG_STAAC
Sequence: MKMTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] reductase FabG, 3-ketoacyl-acyl carrier protein reductase, Beta-Ketoacyl-acyl carrier protein reductase, Beta-ketoacyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UBP16_BOVIN
Sequence: MGKKRTKGKTVPIDDSSESLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKSEEETEENPSVWLCLKCGHQGCGRNSQEQHALKHYMKPRSEPHCLVLSLDNWSVWCYLCDDEVHYCNSNRLGQVVDYVRKQAGNTTPESAEDNGNIELENKKLEKESKNEQEREKKENMARENPSMNSTSQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGIVTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFDNSTEKVDEELKNKVKEYEKKKSVPSFVDRIFGGELTSTIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSINDKNLKKTMEDEDKDSEEEKDNDSYLKERNDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDVYAIDHPEDNECEVEMSLQREADIKSNHISQEEVAPKEYCVNQKDLNGHEKMIESITDNQKSTEEAAMKNVSVDNDLEVLASSATECPRNLNGAYLKEGSNGEVDISSGFENLNLNAALQPDEINIEILDDDPTPGTKVYEVVNEDPETAFCTLANREAFNTDECSVQHCLYQFTRNEKLRDANKLLCEVCTRRQYSGPKANMKGERKHIYTNAKKQMLISLAPPVLTLHFKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEEHTRVLYSLYGVVEHSGTMRSGHYTAYAKTRTASTHLSNLVLHGDIPQDFEMESTKGQWFHISDTHVQAVPTTKVLSSQAYLLFYERIL
What is the function of this protein?
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator.  Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis.  In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes.  Regulates Hox gene expression via histone H2A deubiquitination.  Prefers nucleosomal substrates.  Does not deubiquitinate histone H2B.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-specific-processing protease 16.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP16 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRF_MOUSE
Sequence: MRLRLLVSAGMLLVALSSCLPCRALLSRGSVPRAPRAPQPLNFLQPEQPQQPQPVLIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANFFRVLLQQLQMPQRSLDSRAEPAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
What is the function of this protein?
Hormone regulating the release of corticotropin from pituitary gland.  Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (PubMed:23470617).
What are the official names of this protein?
Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: YHAM_SHIFL
Sequence: MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCNEILFSRAKVWNGEKWACVTIVGGHTNIVHIETHNGVVFTHQACVAEGEQESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGKWGLHIGATLEKQCERGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITAIMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.