PharMolix/UniProtQA huggingface dataset:
Protein: RUBIC_HUMAN
Sequence: MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
What is the function of this protein?
Involved in regulation of pathogen-specific host defense of activated macrophages.  Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways.  Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966).  Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967).
What are the official names of this protein?
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, Rubicon, Beclin-1 associated RUN domain containing protein, Baron.
What are the subcellular locations of this protein?
Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
Protein: CYB_CHAAB
Sequence: MTILRKSHPLMKMVNHAFIDLPTPSNISGWWNFGSLLGLCLIIQIASGLFLAMHYTSDTITAFSSVAHICRDVNYGWLIRYIHANGASLFFICLYLHIGRGIYYGSYMYKETWNIGIMLLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGSTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAATAMVHLLFLHETGSNNPLGIPSDSDKIPFHPYYTFKDLLGVIIILASFLSFVLFFPDLLGDPDNYSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALVLSILVLALFPLLHTANQRSMMFRPISQFLFWTLVSDLFILTWIGGQPVEPPFIIIGQVASILYFSIILVFLPIAGLIENKVLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YLBG_BACSU
Sequence: MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMDQIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI
What are the official names of this protein?
UPF0298 protein YlbG.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_MYCTO
Sequence: MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVPSFG
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: MCH_METS4
Sequence: MSSTTVRPSVNALATPLVEALVADAAKLRLSVSAKSGEARLVDAGAQARGSIEAGRRIAEICLGGLGTVTIAPAGPVAAWPVTVTVHSADPVLACLGSQYAGWSLADEGGSSGFFALGSGPGRAAAAAEHLFEELHYRDHAAQIALVLESASAPPASVVAKVAEAAGVTPDAVTFIYAPTQSLAGATQVVARVLEVALHKAHSVGFDLAKVVDGIGAAPLSPPHPDFIQAMGRTNDAIIYGGRVQLFVEADDAEARGLAEALPSTTSRDHGAPFAEIFARFNGDFYAIDKHLFSPAEVVVTSLLSGTSHRAGRLVPELVERSFA
What is the function of this protein?
Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAPC2_MYCTO
Sequence: MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Acts as an RNase.  All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2 (By similarity).
What are the official names of this protein?
Ribonuclease VapC2, RNase VapC2, Toxin VapC2.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: NDH_STAAB
Sequence: MAQDRKKVLVLGAGYAGLQTVTKLQKTISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase, NDH-2.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MCM7_BOVIN
Sequence: MALKDYVLEKDKVKKFLQEFYQDDESGKKQFKYGNQLVQLAHREQVAMYVDLDDIAEDDPELVDSICENTKRYARLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGAARSPQNQYPPELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQMVQGLLSETYLEAHRIVKMSKSEEDESGAGELTREELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCREKQPAVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDTVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSEGQSVRFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTARTRITFV
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  Required for S-phase checkpoint activation upon UV-induced damage.
What are the official names of this protein?
DNA replication licensing factor MCM7.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: RUVC_ECO45
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: EFTU_BRAHO
Sequence: MAKGTYEGNKTHVNVGTIGHVDHGKTTLTSAITAVSSAMFPATVQKVAYDSVAKASESQGRRDPTKILTIATSHVEYESDNRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSAEDGVMPQTKEHVLLSRQVGVNYIVVFLNKCDKLDDPEMAEIVEAEVIDVLDHYGFDGSKTPIIRGSAIKAIQAIEAGKDPRTDPDCKCILDLLNALDTYIPDPVREVDKDFLMSIEDVYSIPGRGTVVTGRIERGKIEKGNEVEIVGIRPTQKTTCTGVEMFKKEVVGIAGYNVGCLLRGIERKAVERGQVLAKPGTITPHKKFEAEVYILKKEEGGRHSGFVSGYRPQMYFRTTDVTGVINLQGDAQMIMPGDNANLTIELITPIAMEEKQRFAIREGGKTVGNGVVTKNIRII
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URM1_CANGA
Sequence: MVKVRVEFLGGLDVIVNKQRVYDLDVPSQVENVGDLIDYIIENLITNKKDVEVFIENDSIRPGIITLINDTDWELENEKEYVIEDGDVISFTSTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_ACIF5
Sequence: MEAFTVVEAVVAPLDRPNVDTDAIIPKQFLKTIERKGLGKHLFDAWRYLERDGKQVNNPDFVLNQPAYAGAQILLARENFGCGSSREHAPWALADYGFRAVIAPSFADIFANNCVQNGILLVRLPMDVVDHLFHEVAANPGYRLRIDLPAQEVQTMGDSRYAFPMDAGHKHKLMHGLDDIQLTLQRDNAIRVYEARRRQTAPWLFRD
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: KC1D_MOUSE
Sequence: MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
What is the function of this protein?
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms.  It can phosphorylate a large number of proteins.  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2.  Central component of the circadian clock.  In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  Controls PER1 and PER2 nuclear transport and degradation.  YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.  DNMT1 phosphorylation reduces its DNA-binding activity.  Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.  Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth.  Phosphorylates NEDD9/HEF1 (PubMed:29191835).  EIF6 phosphorylation promotes its nuclear export.  Triggers down-regulation of dopamine receptors in the forebrain.  Activates DCK in vitro by phosphorylation.  TOP2A phosphorylation favors DNA cleavable complex formation.  May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast.  Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.  Probably involved in lymphocyte physiology.  Regulates fast synaptic transmission mediated by glutamate.
What are the official names of this protein?
Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity (By similarity).
Protein: DCTA_SALTI
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHYYPELGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALINGLIIVNVVQPGAGMNVDPATLDAQAVAVYAAQAKEQGIIAFLMDVIPGSVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGSLVQLGQLIICFYITCILFVVVVLGTIARVTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKELDHQKLDDVLNNRAPDGKTHEISS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
Aerobic C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL24_SINMW
Sequence: MQKIRKGDKVVVLTGKDKGRTGEVIQVMPKEDRAVVRGVNVVKRHQRQTQNQEAGIITKEAPIHLSNIAIADPKDGKPTRVGFKIDGDKKVRVAKRSGDVIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MASZ_MYCPA
Sequence: MTDRVSAGNLRVARVLYDFVNDEALPGTDIDPDSFWAGVDKVVTDLTPRNQELLRRRDELQAQIDKWHRQRVIEPLDIDAYRDFLIEIGYLLPEPEDFTITTSGVDDEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGSSYNKVRGDKVIAYARNFLDQAVPLESGSWADATGLSVEDGRLQVATADGSVGLAEPAKFAGYTGQLGSPDWSVLLVNHGLHIEILIDPQSPVGKTDRAGIKDVVLESAVTTIMDFEDSVAAVDADDKVLGYRNWLGLNKGDLSEEVSKDGKTFTRVLNADRTYTTPDGQGELTLPGRSLLFVRNVGHLMTNDAIVWSDGDEEKEVFEGIMDALFTGLTAIHGLKTGEANGPLQNSRTGSIYIVKPKMHGPDEVAFTCELFSRVEDVLGLPQGTLKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMIRKGAMKNTTWIKAYEDANVDIGLAAGFKGKAQIGKGMWAMTELMADMVEQKIGQPKAGATTAWVPSPTAATLHAMHYHYVDVGAVQEELAGKKRTTIEQLLTIPLAKELAWAPEEIREEVDNNCQSILGYVVRWVAQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITEEDVRASLERMAPLVDAQNAKDAAYQPMAPNFDDSLAFLAAQDLILTGTQQPNGYTEPILHRRRREVKARAAQSN
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISYM_DICDI
Sequence: MFARLARANYLKNSGRYFSTEPTLKERLVQIIPGKIEQVKQLKTEHGDKIIGTCTVAQAYGGMRSVKSLVTETSSLDPEEGIRFRGLTIPECQEKLPKAPGGAEPLPEGILWLLLTGEVPTESQVKTLSKDLAKRAGLPKHVTSMIKAFPEQMHPMSQLAAAILALQGESKFVKAYNDGVKKDKYWESTLEDSLDVIAKLPEVAALIYQNTYKKSDITHKIDENLDWSANFNRMLGYTSKDFDELMRLYLTIHTDHEGGNVSAHTTHLVGSALSDSYLSLSAGMCGLAGPLHGLANQEVLSWTMKLQEKLGNKEVSNEVLSEAIWEGLNAGRVVPGFGHAVLRKTDPRYTCQREFALKHLPQDPLFKLVSQIYEVVPDILTKHGKTKNPYPNVDAHSGCLLQYYGLKEHNFYTVLFGVSRAIGVLSSLVWDRILGHPIERPKSVTTEWISSYVNSDQSKK
What are the official names of this protein?
Citrate synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GSA_CROS5
Sequence: MVSTTSLKTTKSEDIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDHVKGAYIWDVDGNQYIDYVGTWGPAICGHAHPEVIAALHDALDRGTSFGAPCLLENVLAEMVIDAVPSIEMVRFVNSGTEACMSVLRLMRAFTGRDKIIKFQGCYHGHADMFLVQAGSGVATLGLPDSPGVPKTTTANTLTAPYNDLEAVKALFAENPDEIAGVILEPVVGNSGFVVPDGGFLQGLRELTNEYGALLVFDEVMTGFRLSYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMYQAGTLSGNPLAMTAGIKTLELLQKPGTYNQLEQITQQLSEGLLKIAKEAGHQVCGGYIGAMFGLFFTEGPVRNYDDAKKSDLAKFGRFHRGMLEKGVYLAPSQFEAGFTSLAHTSEDIEKTLAAAKDVLSNL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_TOXGO
Sequence: MVSRTLSLSMSLFRAHLVFYRCALNLNSSYNFGFLVAMTFVLQIITGITLAFRYTSEASCAFASVQHLVREVAAGWEFRMLHATTASFVFLCILIHMTRGLYNWSYSYLTTAWMSGLVLYLLTIATAFLGYVLPWGQMSFWGATVITNLLSPIPYLVPWLLGGYYVSDVTLKRFFVLHFILPFIGCIIIVLHIFYLHLNGSSNPAGIDTALKVAFYPHMLMTDAKCLSYLIGLIFLQAAFGLMELSHPDNSIPVNRFVTPLHIVPEWYFLAYYAVLKVIPSKTGGLLVFMSSLINLGLLSEIRALNTRMLIRQQFMTRNVVSGWVIIWVYSMIFLIIIGSAIPQATYILYGRLATILYLTTGLVLCLY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CELF2_HUMAN
Sequence: MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of several post-transcriptional events.  Involved in pre-mRNA alternative splicing, mRNA translation and stability.  Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.  Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle.  Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB.  Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs.  Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA.  Involved in the apoB RNA editing activity.  Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity).  Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity).  Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK.  Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5.  Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs.  Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine.  Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity).  Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity).  Binds to (CUG)n repeats (By similarity).  May be a specific regulator of miRNA biogenesis.  Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).
What are the official names of this protein?
CUGBP Elav-like family member 2, CELF-2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, ETR-3, Neuroblastoma apoptosis-related RNA-binding protein, hNAPOR, RNA-binding protein BRUNOL-3.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.