Protein: CHD8_XENTR
Sequence: MADPIMDLFDDPNLFGLDSLTGDSFGRDGPDTIDDALGLGNVLGPLEPITDRVGLPGADVGNNEVKQQTESQVLPDNPALMSATEIMQPIQLPTNQETLNQGNPFMGASNAGAPKIMILKAPAGMTVGACPVTQIQTLTPHQAANGGKVAFAKVLTGTPLRPGVSIVSGNTVLAKMPSTGVAGQVGAVRPVRQLLLQPVRASAAPGSSESNTGIKPAITLTSAPQQGDPKRITLVLQQPSQVGATAQQGQRHVVLGGLPGKIVLQGNQLAALTQAKTPQGQPAKVVTIQLQVQQQPGAAGQTPQKFQIVQQAPGGVAIAPSGQHTHMLNQQGVQRLSVPLKVVLQPQAGSSQGTAQGLSVVKVLNASEVANLTASQTVVKTSTGGGESRKLDSQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVNPEDDDGSRRKRKKKKGETSDRSKDEKPKKVKGSGSLRSRSKGKPSTITPIVGKKRKRNPSSDNSDAEIMASQASPAEDEDSVQKRRSNRQVKRKKYTEDLDIKITDDEDDEEVDVTGPVKTEPVLLPEPMPLPDSEAVPSMQFFVENPSEEDAAIVDKILSMRLAKKELPTGEYVEVEEYFVKYKNYSYLHCEWATIEQLERDKRIHQKLKRFKTKMTQMQHFLQEDEESFNPDYVEVDRILDESHSTDKDNGEPVVYYLVKWCSLPYEDSTWELKEDVDDGKIEEFKRIEARQPNLKRVARPAATSWKKLELSREYQNGNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSITFLQEVYNVGIRGPFLVIAPLSTITNWEREFGSWTQMNTIVYHGSLASRQMIQQYEMYCKDSKGRLIPGAYKFDALITTFEMVLSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPTQFSSEAEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGASQSNTPNLLNTMMELRKCCNHPYLITGAEEKIISEFREATPVVPPDFHVQAMVRSSGKLVLIDKLLPKLRAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNMRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDNHLSGPIQQFTKKEIEDLLRKGAYAAIMDEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFSKASFVASENRTDISLDDPNFWQKWAKKADLDLDLLSSKNTLVIDTPRIRKQTRHFTNKDDDMVEFSDLESDDDDRPKARRQDRKHGYGRTDCFRVEKHLLVYGWGRWRDILTHGRFKRGMNERDVEKICRAILVYCLLHYRGDENIKSFIWDLITPAENGKTKQLQNHSGLSIPVPRGRKGKKVKSQSSFDIHKADWIHKYNPDTLFQDEGYKKHLKHQCNKVLLRVRMLYFLRQEVIGNQAMKVLSGVEARQIDIWFPQVDQVEVPSRWWDREADKSLLIGVFKHGYEKYNTMRADPALCFLEKVGGPDEQAIAAEHHAQDFSELPDGGDFDRDIEDPEYKPLHAQKDPEDEIDSLMMDEEISVVDGEEATAMPSGMLWPPGSALTARLRRLITAYQRSYKREQLKLEAEERGDKRRKRCEAAFKLKEIARREKQQRWTRREACDFFRVLSSFGVEYDPDTQLYDWQRFRGLARLDKKTDESLLKYFHGFVAMCRQVCRLPPAAGDEPPDPSLFIEPISEERASRALFRLDLLRRVREQVLCHPLLIPRLSLCRPDPELPEWWESGRHDNELLQGAARYGLSRTDLTILQDHAFSFLRCQISYFQSRGISGHSRPSTPTTAPSVPTERQPSHLASLSSSVSCSPAPRRSSSCSSSSHSSNSEDSSDESNGVKVKPNAGLSHARLYDEESRLSLTASPADLTTEDSIQTALETPHSTDWPKDRVLICRIEQVCSAVLTGKWSSPRRLSDPPSDSPDSLPPTPEQQSPAHFTQIRPAPDPKEFTIQIKSEEGLKIKFQKHKFMGNGALDSAPHTQKKKSKKKMDLDMDTRIPVVNQKDGTLLLGEEAPLRCQLPEWLHRNPDFMVDPRFIAVSGYWIPYINRGKHFL
What is the function of this protein?
DNA helicase that acts as a chromatin remodeling factor and regulates transcription.  Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes.  Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity.  Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity.  Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive genes.  May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription.
What are the official names of this protein?
Chromodomain-helicase-DNA-binding protein 8, CHD-8, ATP-dependent helicase CHD8.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
What are the subcellular locations of this protein?
Nucleus.