PharMolix/UniProtQA huggingface dataset:
Protein: ADA23_HUMAN
Sequence: MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI
What is the function of this protein?
May play a role in cell-cell and cell-matrix interactions.  This is a non-catalytic metalloprotease-like protein.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
Protein: FLGF_BUCBP
Sequence: MESIVNAIITSTNKIFENQARIANNITNISTPGFKSELELKILLPSQKDQNSQEDNFLYKQYKNKNQGTLRRTNQPLDCAIIDKNDWFVIKIDPKTIAYTKNGHFKINSNRQLTVQNHPVLGEDGEIFIPKNENIVISSDGYINIIKNNVLQHKVAQFKLKNFDINDLTYKTNGLYLLNKNNKLNHTNHKNVSNIKLVSGILEDSNVNLEENMVEMISNARKFDMQIKILSMYNENTQAASRFLNLNY
What are the official names of this protein?
Flagellar basal-body rod protein FlgF.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: ZIP2_SCHPO
Sequence: MNNSKGWILSLSINAFCVFGASGIYLDKLVNKWFGYEVLDLANSDNALVTGLATSSGILLYSSWASVMQESFHFLEKISMFDTFLVRVFQFCAFFFGGIVFYIFNHFLHKWLHESSQTGFLHDHFSVSDPSPSTAQNHRSPPASCKRLSSCESSGSPSSRVVGSLQGSYCPSGTHLHEGSLLLEDSSARHSSDSVHEYLVKKPSNCDCECHAHFSSFPTHSGTPDDIEHIHSVYTMGIQTALLICLHKVPEGFITFLASTVDTGFMVLVAMSIHNIVEGFTIAYPLYLAWKSRPKAFLTAATLSSCSLPLGSLIAFLVMEAGGIGSSDFLNFLYGIIFAGTAGMMLILSLRVILPEALRHDHSENKRHSFICFTIGILFTLFLEIFDSH
What is the function of this protein?
Probable zinc transporter that may mediate zinc remobilization from the endoplasmic reticulum under zinc limitation.
What are the official names of this protein?
Probable zinc transporter zip2.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PCP_BACC3
Sequence: MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPEFIICIGQAGGRPNITIERVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEVGGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_VIBCH
Sequence: MALLQIAEPGQSSAPHQHKLAAGIDLGTTNSLVASVRSGTASTLVDSQGRSILPSVVNYGADATRVGYPAREQAETDPHNTVISVKRLLGRSLQDINQRYPHLPYRFKASEKGLPIVQTAQGDKNPIQISADILKALAERATATLGGELAGVVITVPAYFDDAQRVATKDAAALAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLIADHLQAQIGLTSLTAEQQRALINAATQAKIDLTEYMTAELNVLGWQGSLTREELENLIAPLLKKTLLSCRRALKDAGVEADEVLEVVMVGGSTRTPFVREQVGEFFGRTPLTSINPDEVVAIGAAIQADILAGNKPDAEMLLLDVIPLSLGIETMGGLVEKIIPRNTTIPVARAQEFTTFKDGQTAMSVHVVQGEREMVDDCRSLARFSLKGIPPMAAGAAHIRVTYQVDADGLLSVTALEKSTGVQAEIQVKPSYGLSDDEVTQMLKDSMAYAKEDMLARALAEQRVEADRVIEGLVSALQADGDELLNEQERQTLLQAIERLIELRNGDNADAIEQGIKDTDKASQDFASRRMDKSIRSALAGHSVDEI
What is the function of this protein?
Probable chaperone.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ZFP30_HUMAN
Sequence: MARDLVMFRDVAVDFSQEEWECLNSYQRNLYRDVILENYSNLVSLAGCSISKPDVITLLEQGKEPWMVVRDEKRRWTLDLESRYDTKKLFQGKDIYEMNLSQWKVMERIKSCGLEEQESPHEVCFRQVTKTTSEKMPTYRKLTSLPLYQKSHNREKPYECGECGKAFRVRQQLTFHQRIHTGEKPYECKECGKAFRQCAHLSRHQRIHTSDKLYECKKCGKIFTCGSDLRVHQRIHIGEKPYECKECGKAFRVRGQLNLHQRIHTGEKPYECKECGKAFRQYAHLTRHQRLNIAEKCYECKECGQAFLCSTGLRLHHKLHTGEKPYECKECGKAFRVRQQLTLHQRIHTGEKPYDCKECGKTFSRGYHLTLHQRIHTGEKPYECKECQKFFRRYSELISHQGIHIGEKPYECKECGKAFRLFSQLTQHQSIHFGEKPFKCKECEKTFRLLSQLTQHQSIHTGEKPYDCKECGKAFRLHSSLIQHQRIHSGEKPYKCKECKKAFRQHSHLTYHQRIHNVT
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 30 homolog, Zfp-30, Zinc finger protein 745.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUCM_ECO27
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_HOUCO
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RL35_MESHJ
Sequence: MSKIKFKTKSALKKRIKVTGTGKVKHGHAYRSHLAQSKTTKQKRQSRKSTLMNNSDFKRLKKLI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RS8_PYRAB
Sequence: MTLLDPLANALSHITNSERVGKREVYIKPASKLIGEVLRVMQKYGYIGEFEFIDDGRAGVYRVQLLGKINKAGAIKPRFPVKARDYERWEKRFLPAFEFGILIVSTSQGVMSHKEAREKGIGGRLIAYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: MVHB_METFE
Sequence: MIVINKEDCIRCGACQGVCPTGAISVKPEDVIYCDMCGGEPKCVEACPNDALRHEDITLEGGIKKKKITYSPEKCDKCGECVKVCPPGILKLVNDGKASRVPLEGFCVLCQQCVNVCPIEVIGIEGVKEPARVEIKIDKPIYIVDCVGCGLCVPECPVNAITLPKYGESIEIDEEKCIKCGICAQTCPWNSVYISGKKPQKSSRTIENFTLDKEECIGCNTCVEICPGGFIEPKSDLTVSLPEICPACGLCEKLCPTDAIELEVKLGPAKPVTEEGIVYNDENCKFCGRCALNCPNEAIRVVSPKGRVFPGLKKVDEKESYTICTTCGACTTVCPTGALKLVEVSKKVNGETVKRNRIQYNPSLCDKCGNCVDVCPYGILKLTDDEKLPVKGFCILCEKCIDACRFNALLIK
What are the official names of this protein?
Polyferredoxin protein MvhB.
Protein: RR7_SORBI
Sequence: MSRRGTAEKRTAKSDPIFRNRLVNMVVNRIMKDGKKSLAYQILYRAVKKIQQKTETNPLLVLRQAIRRVTPNIGVKTRRNKKGSTRKVPIEIGSKQGRALAIRWLLEASQKRPGRNMAFKLSSELVDAAKGSGGAIRKKEATHRMAEANRALAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PUR9_LATSS
Sequence: MKRALISVSDKTGIVAFAQGLVAADFEIISTGGTFSVLEKAGVPVTPIDEVTHFPEMLDGRVKTLHPNIHGGLLAKRDEPTHMAALAEHEIAPIDLVCVNLYPFKETIQKPEITQEQAIEQIDIGGPSMLRSAAKNFKSVYVVVDQADYDETLAQLQQDDVTYRRHLAAKAFRHTAAYDSLIAGYLSDADAVEFPEKLSLTYDFKQALRYGENAHQKAAFYQSALPSAFSIAAAHQLHGKELSYNNIKDADAAIKVAAEFSEPCVVAMKHMNPCGVGLGTTIYDAWQKAFAADSVSIFGGIIALNREVDVQTANALHELFLEIVIAPSFAPEALAILEKKKNIRLMTLDFEQAAKADRFETVSVLGGLLVQERDRLTDQASELKTVTTKAPTEDEKEALLFAQRVVKHVKSNAIVVATKGQTLGVGAGQMNRVGSVKIALEQALANGMQAPFVLASDAFFPMDDSVAYAAEHGITAIIQPGGSIKDQDSIDMANQKGVSMVFTNRRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: EIF3L_DROPS
Sequence: MSKYSGEEFSNNGDFYDDFAHTGDPALDMEYERNYYASRMPENVKYFLMNFCQAVKEGNLYDIQNMYENTFPQISDHHFDKSSWPEETEVGALVENDKVFMILYKELYYRHIHARIPGGPKLDQRINSFFNYCDFFNLIISAPNPVMLELPDIWLWELVDEFVYQFQNFAQYRARLTDKSQEEIQQLCVNHSNVWSILCILNVLHSLVDISNIKKQLEAISGGIDPNTVSGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAADAPMEDYVKDPMEHQLQVFMDEVRQQKDLPTTRSYLKLYTTLPLAKLASFIDPNANDDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKIMKFNDLNRKLKNINI
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_COXBN
Sequence: MAKKRYRKVTEGIAHIKATFNNTMISVSDPQGNVLCFRSAGGSGFKGSRKGTPYGAQMASEEVGRLARDNFDMRRIAVRVKGPGAGRDSAIRGLRSAGLEVIHLEDRTPLPHNGCRPRKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PURK_STAAN
Sequence: MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDDEKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNKIIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVNQTEQDMYAKFEGSN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
What are the official names of this protein?
N5-carboxyaminoimidazole ribonucleotide synthase, N5-CAIR synthase, 5-(carboxyamino)imidazole ribonucleotide synthetase.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: FABA_AGRVS
Sequence: MNEKQTSYNYDEILACGRGELFGQGNAQLPLPPMLMFNRITDISETGGPHDKGYIRAEFDITSDLWFFPCHFQGDPVMPGCLGLDAMWQLTGFYLGWLGEPGKGRAISTGEVKFTGMVTPSTKLVEYGIDFKRVMRGRLVLGIADGWMKADGEVIYKATDLRVGLFKEKAD
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_STAA3
Sequence: MTIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKAIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKKKLADWHIGLPEIVQLQYDFEQKYQTKLKDIALTEEAFVSLYKEWQHEK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RD54_PHYIT
Sequence: MRFQSIMMLTITCAGTCLAEGLAPSDQAYRPTMTGLKSRLNDPRPLSTATIATSSERFLRFDTVARDTAGNDEERVGPSWLAKVDGLMHKMVTSSLSAEEAQLKVWIQSQIHPRELFGVLSLGKRAAKLDDNPDFVQWLRLVKDFRANNGNQAFSDLDIYYLLLKTNSPEQLKLLFETLRHTPGMTKIGASMEKSLSGNWIRKALEQDTYPTIVYNTLRLKDAGTKLDDTPMFRQWLEYVEKYWNKNAGAFFGDTQMLTLFQKTMTEEEDIIKLVHMLRNNPGMKSHADKLERYLLLTSESSHKTMADVWLKARETPEEVFRILRLAEKQTAAADDNRMLNLWLRYTQTYRDKIDKNAFSDAEALQFFRKAKPLDFDWEIV
What is the function of this protein?
Effector that specifically binds host autophagy protein ATG8CL of the ATG8 family to stimulate autophagosome formation and subsequent autophagy rather than blocking autophagic flux (PubMed:26765567, PubMed:29932422).  The pathogen remodels host-microbe interface by co-opting the host autophagy machinery which plays a key role in plant immunity (PubMed:29932422).  PexRD54 competes with the autophagy cargo receptor Joka2 to deplete it out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense (PubMed:26765567, PubMed:29932422).
What are the official names of this protein?
RxLR effector protein 54.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm. Note=Localizes to host autophagosomes across the perimicrobial membrane.
Protein: Y2897_MYCTO
Sequence: MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTVPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR
What are the official names of this protein?
Uncharacterized protein MT2965.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.
Protein: MXRA7_HUMAN
Sequence: MEAPAELLAALPALATALALLLAWLLVRRGAAASPEPARAPPEPAPPAEATGAPAPSRPCAPEPAASPAGPEEPGEPAGLGELGEPAGPGEPEGPGDPAAAPAEAEEQAVEARQEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGKLRGNQYKKMMTKEELEEEQRVQKEQLAAIFKLMKDNKETFGEMSDGDVQEQLRLYDM
What are the official names of this protein?
Matrix-remodeling-associated protein 7.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DPO4_PSEU2
Sequence: MTQRKIIHIDCDCFYAAIEMRDEPDLAGKPLAVGGSAERRGVIATCNYEARAYGVRSAMSSRHALKLCPDLTIVKPRMDAYKEASREIHTIFRDYTDLIEPLSLDEAFLDVSEAGHFSGSATRIAQDIRRRVSNQLHITVSAGVAPNKFLAKIASDWKKPNGLFVITPDQVEEFVASLPVTKLHGVGKVTADKLGRLGIVDCADLRSRSKLALVREFGSFGERLWSLAHGIDDRPVQNDSRRQSVSVENTYDTDLPDLAACLEKLPDLLETLSGRMARMEGQYRPGKPFVKVKFHDFTQTTLEQSGAGRDLGSYEQLLAQAFARGGKPVRLLGIGVRLHDLRAAHEQLELFSRQ
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MP1_CARMS
Sequence: MDIEPEVPVVEKQMLAGNRGKQKTRRSVAKDAIRKPASDSTNGGNWVNVADKIEVHIHFNF
What is the function of this protein?
Cell-to-cell movement.  Displays RNA-binding activity.
What are the official names of this protein?
Double gene block protein 1, DGBp1, Movement protein P7.
What is the protein family that this protein belongs to?
Belongs to the carmovirus double gene block protein 1 family.
Protein: CDK12_XENTR
Sequence: MPNPVRHGNKKDSGGSASTMPESSGSVNNKDRQRISSKHKRHKSKHLRESSVPEPQTLSTLKLVEYDDISSDSDTFSDVPAKQERRENDERRPSEKSDKMHKSRHRHQHKRLKEATRTKQVEKERKPEKTQEVMVNKVPSSKDKIISSAKRTADEQEEHGRTSKSSSKDSRSKMHKDKSRREREMKSGHKERSKSHRKRDSSKRYKTSDSPKRKGRSPRRKYGGSPKQDDSHSEGSCGQDYDDSPSRVHASGNFNETYRKNMDSPSYKEPAAYQSSARSPSPYSRKQRSVSPYRRRSSSYERGSGSYSGRSPSPYVRRRSSSPFVSRRSLSRSPAPRKSAKSRSRSPLYPRKSSSSSRSKKQKSQSRSRHSSISPARLPLNSSLGAELSRKKKEIAAAAAAAGRESKGSPLILKKESGDSRVASALDLKKATKVLKLEKPVSEPEMVTATSSETKTISAKKEESEKKPQVQAKDPKISGLKDCKPAAIKEEVLTPKEGVTDRDKDVPPLPPILSPPPPLPTSPPSNIPPLPPLPPSPAVLQQPPPPLPPPPTLTFLPLPTTVAASLTSSHYVRQSSLSTQANSQLPVPSPAKPQPPLIHMVPHMKTSTLPPLPLPPLLLGEDDIESPKEIPPPKSVKKEKDKDRPRHLLTDLPLPPELPGGDPSPPDSPERKVVAPPQPPLKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRRQRQSGIVLEEPPAIKAPRKESVSVPGGDAMKNSSPAPTQPVKTESSVSDLAVLGDITQQLNQSELAVLLNLLQSQTDLSVSQISQLLNVQANPDMQLQLEALNQSITALTGAAVPPQEVEPPKETPTLDQVDPLGAGTQGEVQNVLAVLLSQLLKPQEVVDAPGESNGEQSGSNPTAHITLEEEEEPDKHHEQNEEEEEDAGNYWSP
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation.  Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.  Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'.  Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 12, Cell division protein kinase 12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: METXS_ACIF2
Sequence: MPVEIPADSVGLVTPQTVTFSAPLELECGRSLPGYTLTYETYGTLNAQRSNAILLCHALSGDHHAAGYHSMDDRKPGWWEHLLGPGKAMDTERFFFVCANFIGSCKGSTGPASTNPETGAPWGLDFPMVTVRDWVKTQAELADYLGIEQWAAVVGGSLGGMQVMQWSMDYPERLRHAVVIAAAPKLTAQNIAFNEVCRQAIMTDPEFYNGRYYAHNTKPRRGLSLARMIGHITYLSDNAMRTKFGRDTRGGKAFSFGFDVDFEVESYLRYQGSSFVERFDANSYLYITKALDYFDPASTWGGNLAEAFASTRANFLVISFSSDWRFSPERSREIVQALYTCNRDVSYAEIEAEHGHDSFLMPIPQYVAVLSTYLGRVAEEIGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC62_CANLF
Sequence: MGHRVDYFIASKAVDXLLMKYDKDIKKEKEKGKAESGKE
What is the function of this protein?
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER).  Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides.  Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
What are the official names of this protein?
Translocation protein SEC62, Translocation protein 1, TP-1.
What is the protein family that this protein belongs to?
Belongs to the SEC62 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RHOB_MOUSE
Sequence: MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
What is the function of this protein?
Mediates apoptosis in neoplastically transformed cells after DNA damage.  Not essential for development but affects cell adhesion and growth factor signaling in transformed cells.  Plays a negative role in tumorigenesis as deletion causes tumor formation.  Involved in intracellular protein trafficking of a number of proteins.  Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.  Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.  Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.  Required for genotoxic stress-induced cell death in breast cancer cells.
What are the official names of this protein?
Rho-related GTP-binding protein RhoB.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity). Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.
Protein: CRGA_MYCSS
Sequence: MPKSKVRKKNDFTISPVSRTPVKVKAGPSSVWFVALFVGLMLIGLIWLLVFQLAATNPVDAPGMLQWMADLGPWNYAIAFAFMITGLLLTMRWR
What is the function of this protein?
Involved in cell division.
What are the official names of this protein?
Cell division protein CrgA.
What is the protein family that this protein belongs to?
Belongs to the CrgA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.