PharMolix/UniProtQA huggingface dataset:
Protein: GATB_METTH
Sequence: MKCGLEIHVQLDTRSKLFCRCPTDYQEAPPNTNICPVCLNQPGAKPYPPNRSALEGALKIALMLDCRINPEITYFMRKHYNYPDLPSGYQRTSIPVGLEGELNGVRIREVHIEEDPGQYKPDQGTVDFNRSGIPLIEIVTEPDMTSPEEARNFLRELIRVLEYSGCARGEGTMRADVNISLEGGKRVEIKNINSIKGAYKALKFEMIRQKNLLKRGVEVKQETRAFLESQMITVSMRLKEEAEDYRYIPDPDLPPMKFTDEVVEGLRERIPEAPHLKVKRFMEEYGLREEDARVLTSELELADAFEEVAGSIDPEFAALWMRDELKRVLYYNKISFAESMITPGDIIELLAMIRKKEITSKAAKKIIEEMPLNKKGPREIATEMGLIGIIDESEVIRAVEQAIRENPGAVEDYHAGKEAAINFLVGQVMRMTRGKAEPERTVELIKERI
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RS11_BACAA
Sequence: MARKTNTRKKRVKKNIEAGVAHIRSTFNNTIVTLTDTHGNALSWSSAGALGFRGSRKSTPFAAQMAAETAAKAAMEHGLKTLEVTVKGPGAGREAAIRALQAAGLEVTAIRDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LOLD_RHOPS
Sequence: MEQGAEDIPVVYLHDIKRQYTQGEATLTILNGAKLALWAGQSVALVAPSGSGKSTLLHIAGLLEHPDEGEVYVSGAATTALTDAERTQIRRTDIGFVYQSHRLLPEFTALENVMMPQMIRGLKRSETVSRAKEILAYLGLADRITHRPSELSGGEQQRVAIARAVANAPRVLFADEPTGNLDPHTADHVFKALTQLVKATQVAMLIATHNMELAGRMDRRVSIEDGVIVELE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MMP2_RABIT
Sequence: MEALGARGALAGFLRALCVLGCLLGRATAPPSPVIKFPGDVAPKTDKELAVQYLNTFYGCPKDSCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSNVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDAGTDAGTGPTPTLGPVTPEICTQDIVFDGIAQIRGEIFFFKDRFIWRTVTPGDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPRLIADAWNAIPDHLDAVVDLQGSGHSYFFKGTYYLKLENQSLKSVKVGSIKTDWLGC
What is the function of this protein?
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.  Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).
What are the official names of this protein?
72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).
Protein: PYRC_BUCAP
Sequence: MSKFLKKIKIIKPDDWHVHLRDNEILKKVSQYTGTFYKRAIIMPNLEEPITNCFRSISYRRRILNSMTPNTAFQPLMICYLTEKTSPEELQQGFFKKIFVGAKLYPHCSTTNSKYGIKNINNIYHLFNIMEKIKMPLLIHGEENNLNIDIYDREAKFIENTLKPLRKKFPELKIILEHITTEEAISYIEECNSSYLAGTITPHHLMLNRNNMFIDGIQPHLYCLPLLKRKKHQIALRNVISSGSKNFFLGSDTAPHFHKNKINTFGCAGIFNAPSSLLCYVSVFEEMNALQHFQSFCSENGPNFYNMPINKETITLVKKPHKILEKINIGKNIIVPFLAGKRLDWSIEK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: PNCB_BRUC2
Sequence: MAKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRLADEIDEGELRAQLDHARTLRFSKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFHLPEYELRRKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNLGPFSLDVLYARAKAKMWSKVERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTNAHELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVADWTGFRPDSAPPIEGGERIIEWWKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGFGWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVKLSDNPQKATGDPKEVARYLRFFGNEERVEQLVRV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: MDH_COXB2
Sequence: MAKHVKVAVTGAAGQIGYALLFRLASGQAFGLDTTVDLHLLEIEPALPALKGVVMELEDCAFPLLRNMVVTSDPRVAFNDVNWALLVGAAPRKAGMERKDLLEKNGSIFAGQGKAINENAASDVRIFVVGNPCNTNCLIAMNNAPDIPKDRFYAMTRLDQNRAIGQLALKAGVDVPSVKNMIIWGNHSSTQYPDFYHATIDGKPATEVIRDKNWLLNDFIPVIQQRGAAVIKARGASSAASAANAALDSVWSLINTTPADDNYSVALCAQGRYGVDEGLIFSFPCRTENGVVSVIEEIEHNEFGQQKLKETLDELREERDAVEALGLI
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: BPT_BURM9
Sequence: MTHPTELPLSPLSALQFYATAPYPCSYLDGRVARSQVATPSHLINSDIYTELVKAGFRRSGVFTYRPYCDGCRACVPVRVPVDAFAPNRTQRRTWKRHRALVATVAALHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFRDLDPAENGASTLRMVSMIDILGDGLSSVYTFFDPDESHASYGTYNILWQIEQAKSLRLPYVYLGYWIRESPKMAYKANFHPLEGLVDGRWKVLDPTLADLPPVDAALARAPLPGGHSGTR
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAP1_YEAST
Sequence: MELNDPSIISSSQFSGELSDSDTAAATHKSQQAISNLFQKLAKKGREEKPIGSVESSTDSSNISVATSGNNKESNKKKNKKTAMLNFSSLTDPITNYKPMDLQYKTYAYSMNELYHLKPSLASASYEEDPLISELVRSLPKRKFWRLRMGPPDQKHANNHHFNGNNGGGSWKAGYKNGKNDERRMSRTKNMQGGKRRSQQDDEEKKIDQEMLEMDKNLQLGGDVGHSIADFEDWKAKMKELELKKLSKSKGISNSTAIAPRESASHETPTDLRPVIPRGPSSITDFLNLKRQDKKEESSQQTPGIPVGQPSLSKTSIEQVNELETNSDLGKSSSSRFSSFFNKSATSLPSLDNNNQVPSSNVSVVNNDGNSTPHQSGSRLMSFFKESRSSTPNAESQLLSASDKDNGKMQTLPQFQQQPQQMQPMAFTQHPPNNNAFFNGLLNKGKSETSTPPPPPPGLIAHQGPQFPVMGVPPNFPQRMMPPPPGLVQFQKDSKDVNKKEDRQLRQNKNPNGTRNSKGKQEETATPDLPQQQYMPPPPPPGFFPMHPNFPNGPMPPLPQGFPIPPNGMLPVTGQQPQPPYPNMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLPPGLNSKKNIK
What is the function of this protein?
Can regulate translation through binding to eIF4E.  Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro.  Plays a role in cell growth and is implicated in the TOR signaling cascade.  Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.
What are the official names of this protein?
Protein EAP1, eIF4E-associated protein 1.
Protein: BDNF_CORCI
Sequence: KEVSIRGQGSLAYPGLRTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQPSKEHKDADLYSTRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSF
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_STAAE
Sequence: MAQISKYKRVVLKLSGEALAGEKGFGINPVIIKSVAEQVAEVAKMDCEIAVIVGGGNIWRGKTGSDLGMDRGTADYMGMLATVMNALALQDSLEQLDCDTRVLTSIEMKQVAEPYIRRRAIRHLEKKRIVIFAAGIGNPYFSTDTTAALRAAEVEADVILMGKNNVDGVYSADPKVNKDAVKYEHLTHIQMLQEGLQVMDSTASSFCMDNNIPLTVFSIMEEGNIKRAVMGEKIGTLITK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT33_CONLI
Sequence: MRCVPVFIILLLLSPSAPSVDAHPKTKDDVPLASFHDDAKRTLQRLWIKALCCYGYRFCCPIFGKGK
What are the official names of this protein?
Conotoxin LiC33.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: C90A3_ORYSJ
Sequence: MAAAALLLLAAAAAIVVVAMVLRWLLLLGGPAAGRLGKRALMPPGSTGLPLIGETLRLISAYKTPNPEPFIDERVARHGGVFTTHVFGERTVFSADPAFNRLLLAAEGRAVHSSYPSSIATLLGARSLLLTRGAAHKRLHSLTLTRLGRPASPPLLAHIDRLVLATMRQWEPAATVRLMDEAKKITFNLTVKQLVSIEPGPWTESLRREYVKLIDGFFSIPFPLANLLPFTTYGQALKARKKVAGALREVIKKRMEEKAENGGSIGDDEGKKEKKDMVEELLEAEGGSFSEEEMVDFCLSLLVAGYETTSMLMTLAVKFLTETPAALAELKEEHANIRDMKGKKQPLEWSDYKSMPFTQCVINETLRVGNIISGVFRRANTDIHYKDYTIPKGCKIFASFRAVHLNNEHYENARTFNPWRWQINNKLQNAVGANIFTPFGGGPRLCPGYELARVVVSIFLHHLVTRFSWEETEEDRLVFFPTTRTLKGYPINLRLLSESIC
What is the function of this protein?
Catalyzes the C23-alpha-hydroxylation step in brassinosteroid biosynthesis (Probable).  Converts 6-deoxocathasterone (6-deoxoCT) to 6-deoxoteasterone (6-deoxoTE) in the late C6-oxidation pathway and cathasterone (CT) to teasterone (TE) in the early C6-oxidation pathway of brassinolide (BL) biosynthesis (Probable).
What are the official names of this protein?
Cytochrome P450 90A3, OsCYP90A3, Protein CONSTITUTIVE PHOTOMORPHOGENESIS AND DWARFISM 1, OsCPD1, Steroid 23-alpha-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LPXK_SINFN
Sequence: MVSEAPPFWWTKADWRAYALWPFAWAYGRVAAIRMDRARRAMPPVPLICVGNFTVGGAGKTPTAIALAQAAKARGLKPGFLSRGYGGSLDVTTVVDPGHHRARDVGDEPLLLAREALTVVCRRRVDGARRLAAEGADIIIMDDGFQSARLTFDFALLVIDSMRGIGNGHLVPSGPVRAPIADQLRHATALLKIGHGPAADRLIRRAARAGKAIYVADTVRLDDGSMSGVKVLAWAGIADPEKFYRTVRDAGAIVEETRSFPDHHHFSDDEIADLIDRAASQGYTLVTTAKDMVRLEPGHGRAAELAAKSRVIEIEVRFDDPLAPAKIIDATLAAARARKLRANGKG
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: LEU3_BURM1
Sequence: MKIAVLPGDGIGPEIVTEAVKVLNALDEKFELEQAPVGGAGYEARGHPLPDATLKLAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVAGLDILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQKRAKKLLSVDKSNVLETSQFWRDIMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQADRIERAVKTVLEQGYRTGDIATPGCKQVGTAAMGDAVVAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB_GEOUR
Sequence: MRLSEHIYRTISSIRGPLLFVERVFNARAGEIVRIVHPDGETVDGEVLKIEGETVLIQVFGETRGLGMDAPVAFTDGVKMAPLSPDMIGRVFDGSFHPIDGSPLFVPERWTPATGQPINPTARARPEEFIETGITAIDALNTLVKGQKLPVFSCAGLPSREVAAAVLQNARLAGGGEFVVVFVALGLTHHDYSFYMESLAEMKTGFVAFVNRADEPVVERLLAPRFGLAAAEFLAFNRGMDVLVLITDMTNYCDALREVSTAREELPGRRGYPGYMYSDLASLYERAGRIKGMAGSVTMLPVVTMPEDDITHPIPDLTGYITEGQIVLSRELHQKGVFPPVDVLPSLSRLMQRGIGAGHTRSDHRAIADRLYRHYAKGRDLRRLEAIVGREGMTAGDRVMLDFADAFERELIHQGSARRDINGSLDRGVELLKRFSLEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: UPP_PSEPG
Sequence: MPTREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATQDLPLETYEIDGWCGKVSVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLEAHTYLEKLAPDINQRLALIIDPMLATGGSMVATIDLLKKAGCKEIRAMVLVAAPEGIEVVEKAHPDVKIYTASIDQRLNEHGYIVPGLGDAGDKIFGTKQKDA
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YIH1_SCHPO
Sequence: MENNEEFQDELLALESIYPSCLLPISEQSFTYTLSIPDSSVRLNIQFPLDYPNSAPTVLDAYGIDKTLAEDVLLSVATGDVCIFSYMDLLKELVDIDAEQAAAERESKLQEESDKETPVMLNKSHYVAKTPEIQDEPWKPKFDWKESEPITDRKSTFMAHATRVYSTEEVREALEDLYMDKKVAKANHNMVAYRIISPNGNVIQDNDDDGESAAGSRMSHLLTMMSAENVFVCVSRWFGGVHIGPDRFKHINSSAREAVLLTDAAPSQKKGTEHGKKKKK
What is the function of this protein?
Translational regulator that ensures constant high levels of translation under amino acid starvation.  Plays a role as a negative regulator of the gcn2 kinase activity; impairs gcn1-mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis.  In normal conditions, it resides in a actin complex and has no activity.
What are the official names of this protein?
Protein IMPACT homolog.
What is the protein family that this protein belongs to?
Belongs to the IMPACT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPH_FRATO
Sequence: MKILLANPRGFCAGVSRAVETVEKVLEVEKSPVYVRHEVVHNKVVVDSLKKKGVVFVKEVDEVPDDAVCIFSAHGVSLKVEEAAAKKNLVLYDATCPLVTKVHRGVRLASNNDAECILIGHKGHPEVQGTMGQYRSKKGAIYLIESEEDLNKLTIKDPDNLYYATQTTLSVDETHGIIQALKDKYPNIKGPKKEDICYATQNRQTAIKAMLKHIDVLVVVGSQNSSNSNRLKELATLEGIDAYLVDNPKDVDKLWFDNKKVCGVSAGASAPEYLVQQIISQISKVCSTEVEEFEGIKEEVYFPLPRLLKQKIGTGKVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NUOB_MARMM
Sequence: MASDLTPHAGMAGRATVPGYDPKKHDPFFDGVSDALADKGFVVAAADDLVTWARTGSLMWMTFGLACCAVEMMQASMPRYDVERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALVYGILQLQKKIRREGSIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CELF1_HUMAN
Sequence: MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of several post-transcriptional events.  Involved in pre-mRNA alternative splicing, mRNA translation and stability.  Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.  Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.  Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs.  Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB.  Promotes exclusion of exon 11 of the INSR pre-mRNA.  Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.  Increases translation and controls the choice of translation initiation codon of CEBPB mRNA.  Increases mRNA translation of CEBPB in aging liver (By similarity).  Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3.  Mediates rapid cytoplasmic mRNA deadenylation.  Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation.  Required for completion of spermatogenesis (By similarity).  Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs).  Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.  Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs.  Binds to the IR RNA.  Binds to the 5'-region of CDKN1A and CEBPB mRNAs.  Binds with the 5'-region of CEBPB mRNA in aging liver.  May be a specific regulator of miRNA biogenesis.  Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).
What are the official names of this protein?
CUGBP Elav-like family member 1, CELF-1, 50 kDa nuclear polyadenylated RNA-binding protein, Bruno-like protein 2, CUG triplet repeat RNA-binding protein 1, CUG-BP1, CUG-BP- and ETR-3-like factor 1, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, EDEN-BP homolog, RNA-binding protein BRUNOL-2.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
Protein: ISY1_CAEEL
Sequence: MARNAEKAMTALARWRRMKEEEERGPIARRPHDVKDCRNLSDAERFRREIVRDASKKITAIQNPGLGEFKLRDLNDEVNRLIKLKHAWEQRIRELGGTDYRKYAQKELDAIGRETGNSRGYKYFGAAKDLPGVRELFEKSTEGEEQRRHRADLLRNIDAHYFGYLDDEDGRLIPLEKLIEEKNIERINKEFAEKQAQKQQTASDAAPENIYKVEEDDDDDLETQESTVIGEDGRPMTIRHVLLPTQQDIEEMLLEQKKQELMAKYLD
What is the function of this protein?
Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10 (PubMed:29664006).  Does not affect the splicing of zip-10 (PubMed:29664006).
What are the official names of this protein?
Protein isy-1.
What is the protein family that this protein belongs to?
Belongs to the ISY1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NHAB_SHEPC
Sequence: MPLTMSQAFIGNFLGNSPKWYKIAILSFLIINPILFFYVSPFVAGWVLVLEFIFTLAMALKCYPLQPGGLLAIEAVAIGMTSANQVLHEIEANLEVLLLLVFMVAGIYFMKQLLLFAFTKIITKVRSKILVSLMFCLTSAFLSAFLDALTVIAVIIAVAVGFYAIYHKVASGKDFSAVHDHTSESNNQLNNSELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFVIRMSPVTVPVLIAGILTCLLVEKFRIFGYGAKLPDAVHKILCDYAAHEDAHRTNKDKMKLVIQVLVGVWLIAGLALHLASVGLVGLSVIILTTAFNGITDEHALGKAFEEALPFTALLAVFFAVVAVIIDQHLFAPVIQWALSYEGNTQLVIFYIANGLLSMVSDNVFVGTVYINEVKAALIDGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLSVVGVLAIETGFLEQATQYFYDSHMIIHHSAKDVIAPLTSH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OPGH_XANC8
Sequence: MDGTVTLSPAPTDLPPVSSLDAGQPTLPPEAPLAMPEQSLREGSLQVRHQRTSPMGIGLRRFYLIGGTLTATAVAVWVMLSVLWPGGFSVLEGCLLGLFVLLFAWIAMSFASAVAGFITVVARAGRKLGIDPDAPLPSLHTRTALLMPTYNEDPRRLLAGLQAIYESVAETGQLEHFDFFVLSDTTREHIGRAEEQVYAELCDSVGGHGRIFYRRRADNAARKAGNVADWVRRFGGNYPQMLILDADSVMTGDTIVRLVAGMEDNPDVGLIQTLPAVVNGQTLFARMQQFGGRVYGPIIAFGVAWWHGAESNYWGHNAIIRTQAFADHAGLPSLRGRKPFGGHVLSHDFVEAALMRRGGWAMHMVPYLQGSYEEGPPTLTDLLVRDRRWCQGNLQHAKVVGAKGLHWISRMHMMIGIGHYFTAPMWGMLMLVGIGIPLAGAGIDLAQGLPFSPARYWHGSSDGNAIWIFVCTMFVLLAPKLLGYIALLLNPRERRACGGAIRAALSILLETVLAALMAPVVMYLQSRGVFEVLAGKDSGWDAQVRDDGKLSWPALIRSYGGLSVFGLFMGTLAYLVSPSLAAWMAPVIVGMVVSIPVVAVTSLRRTGLALRRAGIFCIPEELDPPKVLVRASELRRAAALEPSLI
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOAC_SHEON
Sequence: MSNVFTHINADGNAHMVDVTEKAVTEREARAEAFIEMASTTLEMIMSGSHHKGDVFATARIAGIQAAKKTSDLIPLCHPLMLTKVEVELEAQPEHNRVRITSLCKLSGKTGVEMEALTAASVAALTIYDMCKAVQKDMVISQVRLLEKRGGKSGHFKAE
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.