PharMolix/UniProtQA huggingface dataset:
Protein: THIE_STAEQ
Sequence: MFDSKQLSVYFICGTQDIPKNKSIEQVLKEALEAGITLYQFREKGPNALKGEKKKQLALKLKQLCHSYHVPMIVNDDVQLAQEINADGIHVGQDDMEIQQFASQFKNKIIGLSVGNLKEYQQSDLSKVDYIGVGPMYTTSSKDDASKPVGPSMISQLRLYIHDFPIVAIGGINETNVQPIVDEGADGISVISAITRSTNIDKTVKYFLRYFT
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: SLIK6_HUMAN
Sequence: MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT
What is the function of this protein?
Regulator of neurite outgrowth required for normal hearing and vision.
What are the official names of this protein?
SLIT and NTRK-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the SLITRK family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: WDR55_DROWI
Sequence: MHTHELFKTPLEEDEVEVSEDDVVGFIAEIEQEVVNESDSEIGEYDLGDDIGAPEPFERAAANAEDSISSDGSFNPNDEDSDTDSDDSMLDEPDEAAVGGASKAKRRKDDDGPSGSSNRNQDSDGNAFDMDEDDETDETVRAIIAAIKKPRSAPPEIKLEDFITDICFHPERHIIALATIIGDVHLYEYSNEENKLLKTIEVHAKACRDVEFTEDGRSLITCSKDKSVMITDMETEKLKKLYETAHDDAINKLLVLDERLFASGDDSGTVKLWDFRTKDSIFELKEIEDQVTQMITNDQKKLLLATSADGYLTTFNIGARKLYVQSEPYEEELNCMGIYRGNSKLVVGTSKGRLYSYNWGYFGYHCDMYPGIKSPISLMIPITERIACVAGEDGNIRACHITPYRNLGVVGQHNMPIESMDINTNGELLASSSHNNDVRFWNVKYFEDFGDIKYNEKHNAYKDKRHNLPSSKCTNASDFFADLAKEDNNDNENDDATAGPSNTT
What are the official names of this protein?
WD repeat-containing protein 55 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
Protein: RS11_PSEPW
Sequence: MAKPAARPRKKVKKTVVDGIAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQIAAERAGQAALEYGLKNLDVNVKGPGPGRESAVRALNSCGYKIASITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PYRD_HAEDU
Sequence: MYSLIRKALFSMEAETAHYFSIQALKLMGKLPFSLCSTTLNPVEVMGLKFKNPIGLAAGADKNGEAIDGFAKLGFGFIEVGTVTPLAQDGNNKPRQFRILEAEGIINRNGFNNQGVDVLVENVKKASYDGILGINIGKNATTPIENALDDYQICLHKVYSYADYITVNISSPNTHNLRALQYGEALDHLLAELKTEQAKLAKKFNQYKPLVLKIAPDLTNEEIVSIADSLIRHQMDGVIAGNTTLSRENIAGFNHAHQQGGLSGKPLHTLSTKLISTLAKELKGKIPIIGSGGVHSIDSGQQKIDAGAHLLQLYSAMIYQGPTLIQELAKKIILR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PPR35_BOVIN
Sequence: MMVYNGSQLESVEEGEAVAVPGPPPEPRAPEPGAPVPEPGLDLSLSPRSESPGRGRPNCSPGRRKGRADRRGGARKGRQVRFLLAPPSPVRSGPPPAAASSSEKPEAPQDLGTPVQQSSLALSLELQAARAAAGGQFDAAKAVEEQLRKSFQTRCGLEESVTEGLNVPRSKRLFRDLVSLQVPEEQVLNAALREKLALLPPQARAPPPKEPPGPGPDMTILCDPETLFYESPHLTLEGLPPLRLQLRPRPSEDTFLMHRTLRRWEA
What is the function of this protein?
During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (By similarity).  In addition may play a role in the primary cilia assembly (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 35.
What is the protein family that this protein belongs to?
Belongs to the PPP1R35 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel. Co-localizes with RTTN at the centriole.
Protein: RDRP_SSDRV
Sequence: MKLRNPKAPIRNDRKAQRSFHKMLSLKAQAKLALTIQDRLELGLLSNNFIRKKLQFVDGYCYLKFLRCAERKTAARNLGSDPSLGLMKRKLVPSQYHSWQSNYTLLVTKSSKLTFAHVNRALGGQKLAEVPANCCIGSTICPFLSVPGDHSSYLVNQLPYMNGYCYLKLIRRTCRFNAVVTLGPWPLATDFFDYIIHRNLNKDLGLFKCNLENTINGSFCHIVEADPGSQNCIFPLPQDCRIGGSISEVVKTLGPDKEMIERDAVTEIKKEIAIVRKYNPYHHSSKQQSALESYGIGSDPYAVRSHTHAAEKAIENKLLDIVGMNLRRRSVITMLWQKRNKAHLMGRSNCKDVYVNTIMEAKDLVRYDQFSFGLPSVATSTAFIGDALHHMTPESVFDLFERSPNLMVLHATIVIPPETLLKCRSSNPELYSLRYYDDKFVYIPEGHAGGSYVHEVKNSNWLAISHIQRGGKFLTVKRLETLAAHHYFVIVKGKVETDSIRVFQSPSQVELLDIFADRQSNVRCSLDHAFAIKMERYVHSLKRLELADVTAKTRQLLSSEELLQYSPTDLVKIDNYFYFLAHTSRFNSSEELIGSGFFESLVSPLKQWFSEICEKFLGKSNFHKTLEALEWKVINYDVKTVIYDMSKPWEKLHWKSENNLLSFDLDSNDNPTSLVDNTDCEASYSESTKFDYELVQVEDDFIDIRIPGIDIPIYDSEYLASEEPVEVEESPIPEVLPEIEDNLSDSMSIDGWMSQSLKTFLPEHDDKVLSILEKFGVSKYGQVVGKNLILPITDFKSVQFEKIGQDEFTESLQDRGFGFVSYTPDAERVAVAATDLEHGQGVLITSDEAGELFKKAMPMSVYTCVILGAGGAGKTTFVEKFVKDNPKSFTVVTPLSVLKKEWQRKGAKNVFTYETALKRSLKKPANEYVILDDFTRFPAGWIELYMSLNTKSKYIVIGDSRQADSHSMSGAFANALVPAIDLFAPLSPFYLNWTWRMTRPVANALGHVSWKLPESGKPILSVSSEVPKDCVVLAPSTTLKVGVETVNDKAFTYTSAQGATFDKVAILIDDNITRVCGDKAVYTALSRSKGEIVFVSTVTGPDTFEKVKCTPFLRTFVELVREYELNQPKVREPEEDFVDDVTPVTSQPKVSEEFLIEELNKNSVEKFDREIFRADLGHTDAVKEIGRVTEQIPRQQRSDEALNLVTLDKRVHHATVEENLDELARKKALGNILWTNFKEQYYSGLESVMVDQDLLVSCRAEITKTYLSKTEALLKGGQLRQSPDFDKFKIADFLKTQWVRKTEKYGLPIKAGQTVTSFMQETVMATGTLSRYMRRMFDKLCTNPNVYLHREKTEQDFSTWVKNGWNFSGHATINDCEAFDASQDGAFVEFERLHAEFLGVPRELIDFYVDTKIKSYIWRGTISVMRLSGEGPTYDFNTWANMAFMATKYSIPSVAMTAYSGDDFACDQVLSVKPAFKELECRFKLKEKRFLKSQGRGSYADFCGMIITPNGVIKNPRKLYLSLKSHDEIGTIDKAIVNYYNDLRTLISLGDNIFSALDATETEFFAGCLNVVHDYILRGSNYEGHQNLTLFKKPRTIKWRVERDETRDCLIHMIIQDRKFIRNLLEGVEQTCDNKPNSNLIFRGMTNGYQKRAKFNQLLNRQDEYLDKVLHKSAGQNALRRLTATLDDTQDSTVAEQSAV
What is the function of this protein?
RNA replication.  The protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA replication protein.
What is the protein family that this protein belongs to?
Belongs to the potexvirus/carlavirus RNA replication protein family.
Protein: VE1_HPV52
Sequence: MEDPEGTEGEREGCTGWFEVEAIIEKQTGDNISEDEDENAYDSGTDLIDFIDDSNINNEQAEHEAARALFNAQEGEDDLHAVSAVKRKFTSSPESAGQDGVEKHGSPRAKHICVNTECVLPKRKPCHVEDSGYGNSEVEAQQMADQVDGQNGDWQSNSSQSSGVGASNSDVSCTSIEDNEENSNRTLKSIQNIMCENSIKTTVLFKFKETYGVSFMELVRPFKSNRSSCTDWCIIGMGVTPSVAEGLKVLIQPYSIYAHLQCLTCDRGVLILLLIRFKCGKNRLTVSKLMSQLLNIPETHMVIEPPKLRSATCALYWYRTGLSNISEVYGTTPEWIEQQTVLQHSFDNSIFDFGEMVQWAYDHDITDDSDIAYKYAQLADVNSNAAAFLKSNSQAKIVKDCATMCRHYKRAERKHMNIGQWIQYRCDRIDDGGDWRPIVRFLRYQDIEFTAFLDAFKKFLKGIPKKNCLVLYGPANTGKSYFGMSLIRFLSGCVISYVNSKSHFWLQPLTDAKVGMIDDVTPICWTYIDDYMRNALDGNDISVDVKHRALVQIKCPPLILTTNTNAGTDPRWPYLHSRLVVFHFKNPFPFDENGNPIYEINNENWKSFFSRTWCKLDLIQEEDKENDGVDTGTFKCSAGKNTRSIRS
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SUVR4_ARATH
Sequence: MISLSGLTSSVESDLDMQQAMLTNKDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDENKQSEGSSNGNRGKNLKVIDSPATLKKTYETRSASSGSSIQVVQKQPQLSNGDRKRKYKSRIADITKGSESVKIPLVDDVGSEAVPKFTYIPHNIVYQSAYLHVSLARISDEDCCANCKGNCLSADFPCTCARETSGEYAYTKEGLLKEKFLDTCLKMKKEPDSFPKVYCKDCPLERDHDKGTYGKCDGHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEKDLKDEEALCLDATICGNVARFINHRCEDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKAFRCCCGSESCRDRKIKGSQGKSIERRKIVSAKKQQGSKEVSKKRK
What is the function of this protein?
Histone methyltransferase that converts monomethylated 'Lys-9' of histone H3 (H3K9me1) to dimethylated 'Lys-9' (H3K9me2) in the absence of bound ubiquitin, and to trimethylated 'Lys-9' (H3K9me3) in the presence of bound ubiquitin.  Acts in a locus-specific manner and contributes to the transcriptional silencing of pseudogenes and transposons.  H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
What are the official names of this protein?
Histone-lysine N-methyltransferase SUVR4, Protein SET DOMAIN GROUP 31, Suppressor of variegation 3-9-related protein 4, Su(var)3-9-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with euchromatic regions.
Protein: PSRP_DELAS
Sequence: MHTHTIFVISDGTGITAETFGTAIMAQFDTKSRLVRIPFVDTMDKVHQAVRQINHVAESESHKPIVFTTLVNQDMLDLIESQCKGKVFDMFGTFVRPLELELGQKSLHRVGRFADISESKEYLERMEAINYTLAHDDGQTHQDLTGADVILVGVSRSGKTPTSLYLAMQFGLKVANYPLIPEDFERKQLPPALVPSRKKLFGLTIDPQRLSSIRNERRPDSKYASLVNCRYEVAEAESMMRRSGIPWLSSTTKSIEEIATTILQEVLPQHLGH
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: BGLA_ASPTE
Sequence: MKLSILEAAALTAASVASAQDDLAYSPPYYPSPWADGHGEWSNAYKRAVDIVSQMTLTEKVNLTTGTGWELERCVGQTGSVPRLGIPSLCLQDSPLGIRMSDYNSAFPAGINVAATWDKTLAYQRGKAMGEEFSDKGIDVQLGPAAGPLGRSPDGGRNWEGFSPDPALTGVLFAETIKGIQDAGVIATAKHYILNEQEHFRQVGEAQGYGFNITETVSSNVDDKTMHELYLWPFADAVRAGVGAVMCSYNQINNSYGCQNSLTLNKLLKAELGFQGFVMSDWSAHHSGVGAALAGLDMSMPGDISFDSGTSFYGTNLTVGVLNGTIPQWRVDDMAVRIMAAYYKVGRDRLWTPPNFSSWTRDEYGFAHFFPSEGAYERVNEFVNVQRDHAQVIRRIGADSVVLLKNDGALPLTGQEKTVGILGEDAGSNPKGANGCSDRGCDKGTLAMAWGSGTANFPYLVTPEQAIQNEVLKGRGNVFAVTDNYDTQQIAAVASQSTVSLVFVNADAGEGYLNVDGNMGDRKNLTLWQNGEEVIKTVTEHCNNTVVVIHSVGPVLIDEWYAHPNVTGILWAGLPGQESGNAIADVLYGRVNPGGKTPFTWGKTRASYGDYLLTEPNNGNGAPQDNFNEGVFIDYRRFDKYNETPIYEFGHGLSYTTFELSGLQVQLINGSSYVPTTGQTSAAQTFGKVEDASSYLYPEGLKRISKFIYPWLNSTDLKASTGDPDYGEPNFEYIPEGATDGSPQPRLPASGGPGGNPGLYEDLFQVSVTITNTGKVAGDEVPQLYVSLGGPNEPKRVLRKFERLHLAPGQQKVWTTTLNRRDLANWDVVAQDWKITPYAKTIFVGTSSRKLPLAGRLPRVQ
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase A, Beta-D-glucoside glucohydrolase A, Cellobiase A, Gentiobiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2779_PHOLL
Sequence: MAVGHYDLKRTKNKQYYFNLKASNGEVILTSEMYTTKAAANKGIRSVQANSPAEKNFEIRENKSGKSYFVLKARNYQVIGISESYDNEVAVKKGIQSAIKHGSSVNVRDLTKSE
What are the official names of this protein?
UPF0339 protein plu2779.
What is the protein family that this protein belongs to?
Belongs to the UPF0339 family. Duplicated subfamily.
Protein: ZN431_MOUSE
Sequence: MVDALTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVGYNWEDSNIEEHCESSRRHGRHERNHTGEKPYEGIQYGEAFVHHSSLQMRKIIHTGEKRYKCNQCDKAYSRHSILQIHKRTHSGEKPYECNQCGKAFTQHSHLKIHMVTHTGEKPYKCDQCGKAFAFHSTLQVHKRTHTGEKPYECNQCSKAFAHHCHLRVHKRIHTGEKPYKCDQCGKAFVGQNDLKRHERVHTGEKPYKCNECGKAFVCNASLRTHKTTHTGVKPYECKQCTKSFASHGQLQKHERIHTGEKPYKCDQCGKAFASHDKFQKHERIHIGEKPYKCKQCTKSFASHDKLQKHERIHTGEKPYECKQCTKSFASHNKLQKHERIHTGEKPYKCDQCNKAFVYESYLQVHKKTHTGEKPYKCNECGKAFARHSHLKVHKITHTGEKPYKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQVHKRIHTGEKPYKCDQCGKAFVGSSDLKRHERVHTGRETLQM
What is the function of this protein?
Sequence-specific DNA binding transcriptional repressor.  Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases.  Acts as a specific transcriptional repressor for PTCH1 during embryonic development.  Required for osteoblast differentiation and sonic hedgehog/SHH signaling response.  Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1.
What are the official names of this protein?
Zinc finger protein 431, Zinc finger protein 932.
What are the subcellular locations of this protein?
Nucleus.
Protein: FLGI2_CERS4
Sequence: MLIRLLLLVICLAGPGVAEEIRIKDLVRFDGVRGNDLLGYGLVVGLNGTGDGLRNAPFTEDIMSNLLERLGVNVTGEQYRPKNVAAVFVTATLPPFARAGAQIDVTVSAMGDAKSLLGGTLVMTPLNGADGQIYAVAQGTIIAGGVSAEGQAARVVQGVPTAGTIPEGARVEREVEFEFARLDRVRLALRSPDFTTAGRIEDRINRELGRGVATMLDAGTVSLDLGRLGPPARVMGRIENLEVVPETVARVVVDQRSGTIVMGEDVRISRVAVAQGGLTLRVEEQPMVVQPNPFSRGETVVVPRTTASIQQRPGTGLAEIPAETSLSRVVAGLNALGVAPNDMIDILKSIHAAGALHAEFIVR
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 2, Basal body P-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: INAR1_PIG
Sequence: MLGLLGATTLMLVAGAPWVLPAGGADLRSPENVVVSIIDDNFILKWKSSSESVSNVTFSADYQITGMDNWIKLPGCQYVTSTECNFSSIKLKSVYEKTKLRIRAETGNSTSPWYEVEPFIPFQEAQIGPPDVHLEAEDKAIIINLSPPGTKNSVMWAMDSSSFVYSLVIWKNSSSLEERTKTVYARDKIHQLSPETTYCLKVKAGLRSPRKVGVYSPVYCINTTVKHHLPSPENLEINAENRVYVLKWNYTYENVTFQAQWLHAFLKKIPEDHSDKWKQIPNCENVKTTHCVFPQNVFTKGIFFIRVQASNGNSTSLWSEEKRFNTEMQTILFPPVINMKPINDASLRVGIGAPKESEDKSVNQLYPLIYEVIFRENTSDTERDVLEKRTDFTFSNLKPLTVYCVKARALIENDRWNRSSVFSDTVCEKTKPGSTSQAWLIAGILSAILLFPAVFYGVKVVSRCINYVFFPSSKPPSTIDEYFAEQPLKNLLLSTSEEQTEICFIVENTNTITTIEETDQIDDNHSRCSSQTNRDSGVYSNEDENSGSKIGEEILRQAAV
What is the function of this protein?
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa).  Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response.  Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another.  The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors.  STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).  Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
What are the official names of this protein?
Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Type I interferon receptor 1.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
Protein: AKT2_MOUSE
Sequence: MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTHFPQFSYSASIRE
What is the function of this protein?
One of the few specific substrates of AKT2 identified so far is PITX2.  Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.  AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake.  Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes.  AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2.  Phosphorylates CLK2 on 'Thr-343'.
What are the official names of this protein?
RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta, PKB beta, RAC-PK-beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N- terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (PubMed:20189988).
Protein: PANC_DESVH
Sequence: MQIITEPQTIQQACLRWRADGVHTALVPTMGYYHAGHESLMAHARAVSEKVIVSLFVNPAQFGPGEDFAAYPRDLERDAAMAEAQGVDVLFAPKAEDLYKKDHATWVEVPALSQTMCGLSRPTHFRGVCTVVTKLLMLTMPRIAVFGQKDWQQVAVIRRMVRDLNIPVDIVGRPIVREPDGLAMSSRNIYLTAEERLQAPHIHHGLALGRAITQSGERDAETIKTAIRRYWAQNLPGGEEDYLTIVDPVSLEPVDRLTGATLCATAVRVGQARLLDNMMLLGD
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_METTH
Sequence: MIAIIDYGSGNLRSIANAFRKIGADALVTSDPQILEAADALVLPGVGAFGSAMAKLEGLRETLLGNIMDGKPFLGICLGLQVLLSESQESPGVHGLDLIPGRVIRIPPGNKVPHMGWNQLIIVEDSQLLEGAEDEYFYFVHSYYAEPSNDVVVARTDYGVEMTAAIESDNIHATQFHPEKSGEAGLDVLRNFVEIIRA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_BACC1
Sequence: MNKGRVTQIMGPVVDVKFDGGKLPEIYNALTVKQSNENGELNLTFEVALHLGDDTVRTVAMSSTDGLVRGTEVEDTGKAISVPVGDATLGRVFNVLGDAIDLDGEVPADVRRDPIHRQAPAFEELSTKVEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMSDSGVIKKTAMVFGQMNEPPGARQRVALTGLTMAEYFRDEQGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTNKGSITSIQAVYVPADDYTDPAPATTFAHLDATTNLERRLTQMGIYPAVDPLASTSRALSPEIVGEEHYEVARQVQQTLQRYKELQDIIAILGMDELSEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKDTVRGFKEILEGKYDDLPEDAFRLVGGIEEVIENAKKMMA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SQV8_CAEEL
Sequence: MFPSRLLEKWWLRAFIALVIFFVWQLFYAINRVQSLEEERATLQATIEVLTRKSDGLRTQIFEKERNLVRLNGKVEEIDTQIRDHLSLLPRVNRSTPFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDQKMRYDDPNWTLPRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEKNGSISHFNAVWKPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEKPKLSKESIDRLTKKTGFNSLEAHALGVDN
What is the function of this protein?
Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate (PubMed:11005858).  May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins (PubMed:11005858).  Required for embryonic development (PubMed:9927677).  Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development (PubMed:16828468).  Involved in vulval epithelium invagination (PubMed:9927677).
What are the official names of this protein?
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8, Glucuronyl transferase I, GlcAT-I, Squashed vulva protein 8, Vulval invagination protein sqv-8.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 43 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein.
Protein: YUBL_SALTY
Sequence: MTDNIMSPLKSLPDGTFTHEQAEAVAAQYQNVAIEDDQGTHLRLVVRKDGEMVWRGWNFEPGGEYWLNRCIESHGIRKTQ
What are the official names of this protein?
UPF0401 protein YubL.
What is the protein family that this protein belongs to?
Belongs to the UPF0401 family.
Protein: PXPA_MYCMM
Sequence: MPYIDLNADLGEGFGIWQLGDDDAMLGIVTSANVACGFHAGEPAGLLRVCRAAAERGVRIGAQVGYRDLAGFGRRFIDVDPEDLVAEVVYQIGALQAIAQSCGSTVSYVKPHGALYNTIVTHRDQAAAVAEAVQMVDATLPVLGMTGSVFFQQATDLGLRTVAEAFADRAYRSDGQLVSRREHGAVLADAAAIAQRAVSMVASGKVTAVDGTQVPITMESICVHGDSPGAVQIATAVRDRLTAAGNEIRAFC
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.