PharMolix/UniProtQA huggingface dataset:
Protein: ACSA_XYLFA
Sequence: MSDLYTIDPMLAKDAHVDRAHYKTLYHESLEQPEAFWSNIAQRLEWFKTPTKIKDVSYQLEDVHIRWFEDGELNASVNCLDRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLGNALRHLNIEKGDRVTIYLPMIPDAVVAILACARIGAIHSVVFGGFAPNSIADRINDCGSKLIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGGTINMHTPRDRWFHHVVDIQATECAPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIYWCTADIGWITGHSYIVYGPLANGATVLLFEGVPHYPTVSRFWEVIDKHHVTLFYTAPTAIRALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTIVGNGRCPIVDTWWQTETGGILITPLIGATDLKPGSVTLPFFGIRPALVDTNGQILDGPAAGNLVLLDSWPGQMRTVYGDHQRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPKVAEAAVVGFPHPIKGQGIYAYVTLITGETPSEALHQELLTWVRKEIGAIATPDHVQWAPNLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLLLNERLTH
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: YHN8_YEAST
Sequence: MEALIVFIVLSVSGAFAYKCSYERLWFKVGSLFDIISTSSKKNVIPLASKMEVGSNEDVSSMGNFINKFYTEYSLPSHKVLQSLRVLFSLAMMTYTVTIEIILWQIKVAGMDKEVTFITTWVWPLTAIMLSFILILFQPFFIIISLLNKFYNDKFDIDRLIIVTCIILSTLIALLSYINIGPFQYTKNILTRLSIGGVTVMASLSGLATVSSLYYNFLVIWHKFRNTPMSDPSFRNINNSNNNSKSLLWTTDAYIEEKIQDYEHNIEQNVQILRSLEEEVGENSTFKAELMEKIAWYQLELGKLEALLQQSPQVRTFKKAFEVGFIIYCLHKLIITFLKRIPYIIYHSLKYPDDYDYENFSENAASDPLAITIANILDFSFFRFNYQHDLDSLTKQISLFLSISLFLCCLSAVNTTISYVVTLLPIKFQILALFAMQNDDTANVLPEYTNNSSYKGKKRNYSQEQKGISLIKNLVVSELTGVYVLATTLMVRSHLPFEVSQRLKELLGGKFTVPNIVIDSWFDEVYAFACVFTFICIRIAERKLSTKKVSVE
What are the official names of this protein?
Uncharacterized protein YHR078W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PDE1A_HUMAN
Sequence: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
What is the function of this protein?
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes.  Has a higher efficiency with cGMP compared to cAMP.
What are the official names of this protein?
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Cam-PDE 1A, 61 kDa Cam-PDE, hCam-1.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Protein: CYB_SINJA
Sequence: MSNQHTLLISNLLPVGSNISTWWNFGSMLLTCLMMQIMTGFFLAIHYTANINLAFSSVIHIMRDVPYGWIMQNIHAIGASVFFICIYIHIARGLYYGLYMNKNVWFSGTALLITLMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGATVTTWFWGGFSVNDPTLTGFFALHFILPFTIASLSSIHIILLHNEGSSNPLGTNSDIDKIPFHPYHSYKDMLMTTSMFMLMFMILSFMPDLFNDPENFSKANPLITPQHIKPEWYFLFAYGILRSIPNKLGGTLALLMSVTILITAPFTHTSLVRSMTFRPLAQTLFWTLIATFITITWTATKPVEPPFILISQMASVFYFSFFIMNPLLGWTENKIMMMNS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GRCA_VIBA3
Sequence: MIQGIQITKAANDDLLNSIWLLDSEKNEARCVVATSGFEADQVISAADLGEYESREVAIEAAPRIEGGQHLNVNVLKRETLEDAVAHPENYPQLTIRVSGYAVRFNSLTTEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: SQRD_AQUAE
Sequence: MAKHVVVIGGGVGGIATAYNLRNLMPDLKITLISDRPYFGFTPAFPHLAMGWRKFEDISVPLAPLLPKFNIEFINEKAESIDPDANTVTTQSGKKIEYDYLVIATGPKLVFGAEGQEENSTSICTAEHALETQKKLQELYANPGPVVIGAIPGVSCFGPAYEFALMLHYELKKRGIRYKVPMTFITSEPYLGHFGVGGIGASKRLVEDLFAERNIDWIANVAVKAIEPDKVIYEDLNGNTHEVPAKFTMFMPSFQGPEVVASAGDKVANPANKMVIVNRCFQNPTYKNIFGVGVVTAIPPIEKTPIPTGVPKTGMMIEQMAMAVAHNIVNDIRNNPDKYAPRLSAICIADFGEDAGFFFADPVIPPRERVITKMGKWAHYFKTAFEKYFLWKVRNGNIAPSFEEKVLEIFLKVHPIELCKDCEGAPGSRC
What is the function of this protein?
Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.  Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.
What are the official names of this protein?
Sulfide-quinone reductase, SQR, Sulfide:quinone oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the SQRD family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: MQO_CAMJE
Sequence: MSQQEFDVLVIGAGISGAALFYELARYTNIKNIALIEKYNTAATLNSKGTSNSQTIHCGDIETNYTLEKARKVKRTADMIVKYGLMQNAQNNFMFSHQKMALAVGDIECDYMKKRYEEFKELYPYIKFFDKAKIKQIEPKVVLGEDCNQDRPENICAMGVESGEVFTTVDFGKMSINLIEQAQKQNKNTFVAFNQEIIHIEKKDDIFILKTSNHQEYHAKSVVVNAGAHSLYLAHKMNLGMDKSCWPVAGSFYLTKQKLLNGKVYMVQNPKLPFAALHGDPDLLADMNTRFGPTALVIPKLERYHGLKSVPEFFEALKLDKTVLKVTFNMFKDATIRNYIFYNYLFELPFVDKSLFVKDAKKIVPSLKASDIYYAKGFGGVRPQVIDKTKGELMLGEASITETPGIIFNMTPSPGATSCLGNAERDAKLVCNYLGMEFNEDKFSSELL
What is the function of this protein?
Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle.  Donates electrons to quinones of the electron transfer chain (By similarity).
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: NORM_XYLFA
Sequence: MFLPRPDFRIALFICFMAVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQLHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPTMLLGFGGLLVLVPLSYALTYGRFGFSEYGVEGLGIATVMVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAWAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGMPLGLGLGFALEWNSRGMWIGLIIGLTAAAVLLGWRFRVVSERMFAGIP
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NLRP3_MACMU
Sequence: MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCISLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKKKKDYCKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREHELLAIGKTKTWESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKIMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIRKIVSKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYTFFLSSLLQPRGGSQEHRLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSCLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTCYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHVVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPGSHAACSHRLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPDCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSRSLTRLYVGENALGDAGVAILCEKAKNPQCNLQKLGLVNSGLTSACCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTIVFEPSW
What is the function of this protein?
Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth.  During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription.  Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'.  May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Inflammasome. Endoplasmic reticulum. Secreted. Nucleus. Note=In macrophages, under resting conditions, mainly located in the cytosol, on the endoplasmic reticulum. After stimulation with inducers of the NLRP3 inflammasome, mitochondria redistribute in the vicinity of the endoplasmic reticulum in the perinuclear region, which results in colocalization of NLRP3 on the endoplasmic reticulum and PYCARD on mitochondria, allowing the activation of inflammasome assembly. After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages. Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells (By similarity). In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus. Nuclear localization depends upon KPNA2. In the Th1 subset of CD4(+) helper T-cells, mainly cytoplasmic (By similarity).
Protein: TTCA_RALSO
Sequence: MTFSNNFHRLETRLQSQAGRAIGDFKMIEDGDTVLVCLSGGKDSYTMLSVLMALQKRAPIDFKLIAMNLDQKQPGFPEDVLPGYLKKVGVEYVIVEADTYSIVKEKVPEGKTTCSLCSRLRRGVIYRTAKELGANKIALGHHRDDIVNTFFLNMFFGGKMKAMPPKLATDNGDHIVIRPLAYCAEKEIAAYARAMEFPIIPCNLCGSQENLQRKKVKEMLLEWERQAPGRIDNIFSALQNVVPSHLADTDLFDFNGLTTGLAKIGEEALFGQTAYDQAPLVFAGSHDDRIEFVRFERNPAGKAPEGAEQPAA
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_STRPN
Sequence: MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSAAKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAEVIKP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y632_METJA
Sequence: MKFFNREKEIEEILHIIESEPQRINFIFGSINSGKTALINEIINNRLNKDKYVVFYFDLREIFISKYDDFIEVLFEEYEEPFIDKVKRLFLSLIKDYPDVIKSYALLNITGVVDSIPIPKNTLNELLKKRNVKNVFRYITSVLIKIKREGKQPIIIIDELQKIGDLKLNGFLIYELFNYFVSLTKHKHLCHVFCLSSDSLFIERVYNEAMLEGRCKYILVDDFDRETALKFMDFLAKENNINLTNEDKELIYNYVGGKPIDIIYVINEMKYKKLEDILTSMLKEETQKLKYFLENVKEEDEELYKKVVDALKIFKDSYEIEDIKIPKKLREFLVKKNILFLNPIEGTLKPQSFLVWNAIKRIL
What are the official names of this protein?
Uncharacterized ATP-binding protein MJ0632.
What is the protein family that this protein belongs to?
Belongs to the archaeal ATPase family.
Protein: HYKK_DANRE
Sequence: MSTKESKPNLSHSQVTDVVKRLYGLTASVVRPLPSYDDQNFYVAPSEGGEFVLKVMNSADSENVAVIELQTQSMNFLHQRGLPAQTALPTLTGQLMSLEEFDCGFGTQIYLVRLLTYLPGTTIAKITCSPQILYDVGKMAATLDTVLLQMEHPNTRVLQRERFIWKLTSIPLLNQYVHVMDGDPVQKIVKGVIEKYQVQVMPKLPLFRECINHGDFNDHNLLVKPDGPSKYKISGILDFADMSCGYFIFELAITIMYMMIESPTPLDVGGPVVAGWESVFPLNEAERDSLYWLVMCRFCQSLVLARYTVIQQPENEEYLMITSRKGLRHLSRLWELGKDEVERRWFQSAQQFRQI
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
What are the official names of this protein?
Hydroxylysine kinase, 5-hydroxy-L-lysine kinase.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM2_STRR6
Sequence: MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADDSREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPGMSFLVTGPKDLVVSKNQVAVLGNGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: SYTL5_HUMAN
Sequence: MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL
What is the function of this protein?
May act as Rab effector protein and play a role in vesicle trafficking.  Binds phospholipids.
What are the official names of this protein?
Synaptotagmin-like protein 5.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: B4GA1_PONAB
Sequence: MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKTQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC
What is the function of this protein?
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1).  Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan.  Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.  Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).
What are the official names of this protein?
Beta-1,4-glucuronyltransferase 1, I-beta-1,3-N-acetylglucosaminyltransferase, iGnT, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 49 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein. Note=Localizes near the trans-Golgi apparatus.
Protein: EF2_SACS2
Sequence: MPRYKTVEQVLSLMKDRTRVRNIGIIAHVDHGKTTTSDTLLAASGIISPKVAGEALALDYLNVEQQRGITVKAANISLYHEAEGKGYVINLIDTPGHVDFSGRVTRSLRVLDGSIVVVDAVEGIMTQTETVLRQSLEERVRPILFINKVDRLVKELKLSPQEMLNRLLDIIRQVNNLIDMYGEPEFKEKWMINPQAGNVIFGSAKDKWGFSLPMAQKKGINMKNVIDAYTASDKSKLEELAAQAPINEALLDAAIKFVPNPIEAQKYRIPKIWKGDLDNELAKAMLNADPNGPIVFMITDMKVDPHAGLVATGRVFSGTLRSGEELWLVNAKTSQRILQVSLYMGPTRELAEEIPAGNIAAVLGLDRARSGETAISVGFSNVQGSFERLHYISEPVVTIAVEPKNPKDLTKMIDALRKLSIEDPNLVVKINEETGEYLLSGMGFLHLEVSLQLLRENYGIDVVTTPPIVVYRESIRAKSQVFEGKSPNKHNKFYLSVEPLNDKTIELISNGTIREDMDSKEMAKILRDEASWDYDEAKRIIAIDENVNVFVDLTSGVQHLREVMDTVLQGFRLAMKEGPLAHEPIRGVKVILHDAVIHEDPAHRGPAQIYPAVRNSIFAGFLTSRPTLLEPIQKLDIRVPADLIGNVTAVITRKRGKILDVSQIANMSRITAEIPVSESYDMASELRGSTGGRAFWGTEFSRWAPVPDSILLDVVTKIRERKGLPKELPKVEDFLS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_VARPS
Sequence: MSDHLIPSIPTPAAAPAAAPAVDDNQLIAERREKLKLMRAAQAEGKGVAFPNDFKPGHRAAALIEAHGAADAEALEAQAVAVSVAGRMMLKRVMGKASFATVQDATSRIQLYVTRDAIGEEAYAEFKRWDLGDIVGAEGTLMKTKTGELSVKVTKLRLLTKSLRPLPDKFHGMADQEQKYRQRYVDLITDETARVRFTARSKAVSALREFMVGHGFLEVETPMLHPIPGGANAKPFKTHHNALDQEMFLRIAPELYLKRLIVGGFERVFEINRSYRNEGISVRHNPEFTMMEFYAAYWNYRDLMDFTETLIRTIADKAVGTQQLTYQGKPVDLTQPFERLTIREAILKYTEAGTGVDDSAWLINALRKIGLSEEKDKLSQRSLASLQVMYFEETVEEKLWQPTFIMEHPTEISPLARANDERPEVTERFELYITGREFGNGFSELNDAEDQAARFNAQVAAKDSGDDEAMFYDHDFVRALEYGMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRRES
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_ARCFU
Sequence: MKVLVVDAGGRGNAIAHAFSRSEQVKEIYIAPGNGGSEFFEKCKIAELDGKKIPSIRAIDEIVRFAKKCEVDLAYIGPEEPLSLGLVDRLEEEGIPAVGPKKEATILEASKCWAKDFLKRIGVPIPEYANFDNPEEAKEYIREKFNNGIVVKADGLAAGKGVYVCDSVEEALRAVDEIMVQKKFGEAGNRIVVEERLRGIEVAFTAMTDGKTVKPFGHARDYKRAFDSDDIEGLRDFYIGLTKKFYTKAQIEQLYREGKLINPNTGGMGAVSPHPAVTEEVEQRIMEMVVEPIIENFDKEFKGVLYPVIMLVEENGELIPKVLEINVRDCDPGAEAKLPRLKSDMAEISMAVVEGRLDEVEMRFSSDYCVAVCAVSGALKGREGLKPGYPADHYTSQPITGIEEAMKEAIIYANGIAKTNGYVTTGGRVLTVVGMGQSIEEARSKAYSALEKISFPGMRYRRTIGLDVPE
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: DRTD_ASPCI
Sequence: MSDTYLVAASGLAVCFFVLYLLRPKTALPPGPPKLPLIGNLHQLGKKPMYERCQEWHRQFGKLISLKLGFDNVVVIGSSQIARDLLDKKGAMYSSRPKFVMAHENVTKGFHTATLPYGPRWRLHNRMQLSVLNKRIVTRCRQVQEFESLQLIHELLFTNDFHPRFQRWANSLQTGLGYGQRLAKGDECNIHEMEHISRVFREIFATGTWLVDLFPALNHLPPLLAPWKGVAEQHYNRTIELFQLNTAAALSKTSWNWTKKIRSLTESQGLPPDEVNFLVGVMAEAGGDTTGVVLDMFTLAAALHPEKMAIAQKEIDTVVGTDRLPNFGDVDKLPYLAALIKECLRWHPAAPFGLPHSVMQDDTYDGYHIPAGTTIIASQWSINFDPETFPNPYEFRPERYLENPDLPISSFGFGRRACPGRYFAMDSLFISISRVLWTFNIRPIKQGKDDPPMPAWEFVMDGALLRPAPFKALFSARDIHRQRFVIKEWAAAEKSVDVEALYDAIEPAGGDFSAQEKEEPVLVA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of various drimane-type sesquiterpene esters, compounds that exhibit diverse biological activities and are widely present in eukaryotes (PubMed:34468074).  The pathway begins with the synthesis of the backbone drimenol by the terpene cyclase drtB using farnesyl pyrophosphate (FPP) as substrate (PubMed:34468074).  The cytochrome P450 monooxygenase drtD is then responsible for the hydroxylations at C-6, C-9 and C-12, as well as the oxidation of hydroxyl groups at C-6 and C-11 to a ketone and an aldehyde, respectively (PubMed:34468074).  Then, the biosynthesis can go in two directions, either the hydroxylated drimenol is further hydroxylated at C-2 and C-3 by an enzyme(s) not associated with the drt cluster, or the FAD-binding oxidoreductase drtC further oxidizes C-11 or C-12 to form the butyrolactone ring (PubMed:34468074).  DrtB, drtD and drtC are solely responsible for the formation of the different drimane structures observed during drimane sesquiterpenes biosynthesis (PubMed:34468074).  The polyketide synthase drtA synthesizes different lengths (C6 and C8) of PKS chains, which are then oxidized to varying degrees by the short-chain dehydrogenase drtF (PubMed:34468074).  Finally, these PKS chains are transferred onto drimane sesquiterpenes by the acyltransferase drtE, forming the sesquiterpene esters (PubMed:34468074).  In addition to the different fatty acyl-CoA chains produced by drtA, drtE is also able to use cinnamoyl-CoA as a substrate (PubMed:34468074).
What are the official names of this protein?
Cytochrome P450 monooxygenase drtD, Drimane-type sesquiterpene ester biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TMFO1_MYCMS
Sequence: MKTIRIIGAGLSGCEAAYYLLKKGYFVELYEIKTIKKNPIQHYDYFCELAYSDSFRSTDLNTSVGTLKKELELLDSLIIKAAKYASINQNNELVVNRIEFSKYITNYLKTFNNLKIIEQEYLNIDLNIPTIIAIGPISTPSFLTNLKKIINKKNLKLFDTVEPTILKQSINKNICYSLDNNLDYLYCDLNKEQFEKFYNALISAKTFNSPLKNEIKLLEKNNYFSIESLAKNKQEFINHFKPINNNAYITITLKKDSVIDNLYTIVNFQTSLMWNEQLKVFSLIPGLENLKIMRYGVMHKNNYINTKKLLNLGVQLKTNKNIFFAGQIIGVDGYVESVCSGLISAINLDRYLNNKKMILPNKNSTIGSLYNYLLKTDSNFNPMRINWALVDLIDGFELSDNSKKFYSKRAIELIKQYLKKINYK
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO 1, Folate-dependent tRNA (uracil-5-)-methyltransferase 1, Folate-dependent tRNA(M-5-U54)-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.