PharMolix/UniProtQA huggingface dataset:
Protein: MSH3_EMENI
Sequence: MPLPSSQPSASSSPNLKRKQPTISSFFTKKPQAPKQSTSNEGPAPIDNDSEITDKLAEDDEEDIVAPVPKRTKSNGSLTVNRPQSPKAKSVSRVEQESSQRTELSKFASSPAIETEGNEATELDGSAKVRQQEREKLHQRFVRKLGGPDCLVGIGRNCVGETTSIEEAAEGDEDDETPQPVQPKGKAGKKGGGKLTPMEKQVIEIKKKHMDTILLIEVGYKFRFFGEDARIAAKELSIVCIPGKFRYDEHPSEAHLDRFASASIPVQRLHVHVKRLVAAGHKVGVVRQLETAALKAAGDNRNAPFVRKLTNVYTKSTYIDDIESLEGSTAGASGASATGYILCITETNARGWGNDEKVHVGIVAVQPTTGDIVYDEFDDGFMRSEIETRLLHIAPCEMLIVGELSKATEKLVQHLSGSKMNVFGDKVRVERAPKAKTAAAESHSHVSSFYAEKMKSADAADDEVASNLLQKVLGLPDQVTICLSAMIKHMTEYGLEHVLQLTKYFQHFSSRSHMLLNGNTLTSLEIYQNQTDYSSKGSLFWTLDRTQTRFGQRMLRKWVGRPLLDRRQLEDRVNAVEELKDFRNVVMVERIKGLLGKIKHDLEKGLIRIYYGKCSRPELLTILQTMQMIAQEFADIESPADTGFSSPAISQAIMSLPTILKDVVFFLNKINMHAARNDDKYEFFREEEETEEISEHKLGIGAVEHELEEHRPVAGEALGKKMVTYVSVAGIDYLVEVENNSPAIKRVPASWMKISGTKKVSRFHTPEVVKMIRQRDQHREALAAACDKAFLALQAEIATNYQALRDCVQSLATLDCLVSLATLASQPGYVKPEYTEETCIHVEQGRHPMVEQLLLDSYVPNDINLDSSKTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPAQAAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSIRSLTLFITHYQHLSAMVHSFPDGELRNVHMRFSESGTGADEDITFLYEIGEGVAHRSYGLNVARLANLPAPLLEMAKQKSAELEEKIRRRRLAGFVAAVGAVVQSNQADESVIERLVSSMEEL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: COQ8A_RAT
Sequence: MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQSTAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYCRMKSGLQ
What is the function of this protein?
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.  Its substrate specificity is unclear: does not show any protein kinase activity.  Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates.  Shows an unusual selectivity for binding ADP over ATP.
What are the official names of this protein?
Atypical kinase COQ8A, mitochondrial, Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, Coenzyme Q protein 8A, aarF domain-containing protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single-pass membrane protein.
Protein: NDHI_RANMC
Sequence: MFPMVTGFMNYGQQTVRAARYIGQSLMITLSHANRLPVTIQYPYEKVITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETNIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSAYDRHELNYNQIALGRLPMSVIGDYTIRTITNSTQTEIATGKRFDSKTITNY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TBB_UROFA
Sequence: MREIVHLQTGQCGNQIGAKFWEVVSDEHGIATDGQYKGNTDLQLERISVYYNEVAANKYVPRAVLIDLEPGTMDSVRSGAFGSLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLATPTYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTARGSQQYRAITVPELTSQMFDAKNMMAASDPRHGRYLTVAAYFRGKVSMKEVEENMLSVQNKNSNYFVEWIPNNVQTAHCDIAPRAHKMSVTFIGNSTAIQDLFKRVADQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMQDLVAEYQQYQEAHMDDEEAEEAYEDEAPPEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DJB12_BOVIN
Sequence: MESNKDEAERCISIALKAIQSNQPDRALRFLEKAQRLYPTPRVHALIESLNQKPQPAGDQPQPTEATHTTHRKAAGANTASANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLKKAYRKLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKGQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYHQRQDRRENQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSLRPSVGHVHKRVTDHLNVVYYVADTFSQEYTGSSLKMVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDADMYNKAQKDGAPQAVTDCQRL
What is the function of this protein?
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway.  Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities.  Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers.  While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70.  When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.
What are the official names of this protein?
DnaJ homolog subfamily B member 12.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus.
Protein: SIR4_ARATH
Sequence: MNMRRVFGGVSTDLFPSRSMYRPLQSGGNLVMLFKGCRRFVRTTCRVSIPGGSLGNESKAPPRFLRDRKIVPDADPPNMEDIHKLYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYSSGFKPITHQEFTRSSRARRRYWARSYAGWRRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGSDPLELHGTVYTVMCLECGFSFPRDLFQDQLKAINPKWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHIPVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEILHRVLDVGSLSVPAL
What is the function of this protein?
NAD-dependent protein deacylase.  Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues (By similarity).  Involved in responses to ethylene leading to the transcriptional repression of some ethylene-responsive genes via the regulation of histone acetylation H3K9Ac (PubMed:29298835).  Negatively regulates plant basal defense against plant pathogens, possibly by suppressing salicylic acid biosynthesis (PubMed:20573705).
What are the official names of this protein?
NAD-dependent protein deacylase SRT2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus.
Protein: FUMC_HALSA
Sequence: MSEDYRTEQDSLGEMQVPADAYWGAQTQRAIENFPISGIAFGRRFVRALGVVKKAAAQANRDLGLVDDERADAIVAAADEVIAGEHDDQFPVDVFQTGSGTSSNMNANEVIANRAAELLGEEIGDRVVHPNDHVNYGQSSNDVIPTAMHVASLDALVNDVKPGLETLAAELDDKADAFDGVVKTGRTHLQDATPVRLGQEFGGYRTQVEKGIDRIEAVAPRLSELALGGTAVGTGLNTHPEFPETAAGYISEETGVTFREADNHFEAQAAHDAMNEAHGALRTVAGSLNKIANDLRLLASGPRNGLGEIEQPENQPGSSIMPGKINPVVAEAVNQVHKQVVGNDAAIAAGAAEGQIDLNLYKPVLAHNFLQSADMLANASAAFGEKFVAKLEANEAACEAQVERSMALATALNPTIGYDKASEVAKAALKEGKTVTEVVVEKGYLSEAEAADVLDPEGMTHRGILSGDDT
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_POLNS
Sequence: MAIERTLSIIKPDAVAKNVIGKIYDRFESAGLKIVASKMAHLSQNEAEQFYGVHKDRPFFKDLVSFMISGPVMIQVLQGEGAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVFNR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_BRUA1
Sequence: MRHGNGYRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAISAIRDVRLVAKLFDTLAARYATRNGGYIRIMKAGFRAGDNAPLAVVEFVERDVDAKGKADRARVEAEAAAEADAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TR103_RAT
Sequence: MVVTMRAALRLMLISTVSLELIIGILANVFIALVNIIDWIKRGKISAVDKIYMGLAISRTAFVLSVITGFLIAFLDPASLGIGIMIRLLTMSWTVTNHFSVWFATCLSIFYFLKITNFSNTVFLALKWKVKKVVSVTLVVSLIILFINVIVIHIYTDRFQVNMVQKCGANNTLRAYGLFLSISTVFTFIPFTASLTMFLLLIFSLWRHLKTMHHNATGSRDVSTVAHIKGLQTVVAFLLLYTVFAMSLFSQSLSIDAQHTNLLSHFLRCIGVAFPSGHSCALILGNNKLRQASLSVIFWLRCKYKHTENQGP
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 103, T2R103, Taste receptor type 2 member 15, T2R15.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ENV_HV1LW
Sequence: MRVKEKYQHLRRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGGMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKHDIIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVIRSANLTDNVKTIIVQLNQSVEINCTRPNNNTRKRIRIQRGPGRTFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQYGNNKTIIFKQSSGGDLEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQIINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNNNNGSEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFAVLSIVNRVRQGHSPLSFQTHLPTPGGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: ULAE_SHIBS
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDERLSRLDWSREQRLALVNAIVETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQEANNETRRRFRDGLKESVEMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAEDPAAEVVKARDWVKARMAKAGMVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: LIPA_STRGG
Sequence: MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYKQLQQLVKGEGLHTVCQEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPQALDRDEPRRVGESVVTMDLNYATITGVARDDLEDGGAWLYAETVRQIHTLTAEREAGATKVELLIPDFNAEPEQLAEVFSSRPEVLAHNVETVPRIFKRIRPGFRYERSLEVITRAREAGLITKSNLILGMGETREEVSEALQDLYDAGCELITITQYLRPSVRHHPVERWVKPHEFVELKDEADAIGYSGVMSGPLVRSSYRAGRLFQQAMEARGVAAAGSAQAAQAV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_PINPR
Sequence: MDEFHRYGKEDNSRQQCFLYPLFFQEDLYAISHDHYLDGSSSSEPMEHLSSNDQFSFLTVKRLIGQIRQQNHSIVLFVNCAPNPLADCKKSSYSESVLEGLTLVLEVPFSIRSKYSGMNEWKSFRSIHSIFPFLEDKFPHSNYISDARIPYSIHPEILVRTFRRLIRDAPSLHPLRSVLYEYRNSPENLQRSIIVVPRVNTRFFLFLWNYYVYECESILFSLLKRSSHSRSLSHRPFPQRTHFHRKIKHIIIFSRRNSLKSIWLLKDPKIHYVRYGERSIIAIKGTHLLVKKCRYYLLLFRQCYFHLWSEPYRVCSHQLSKNCSSSPGYFLRVRMNPLFVRTKMLDELFIADLITNEFDPIVPIVPILGLLAREKFCDVSGRPISKLSWTNLTDDDILNRFDQIWRNLFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFQKSFSKEREFDSLPFSSKAAARSQRERIWHSDIPQINPLVNSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ARC_MYCSS
Sequence: MSESQRHEAREDGFTTPHESGLSSEDAAELEELRREAAALREQLENAVGPQSGLRSARDVHQLEARIDSLAARNAKLMDTLKEARQQLLALREEVDRLGQPPSGYGVLLASHEDDTVDVFTSGRKMRLTCSPNIDVKALKQGQTVRLNEALTVVEAGTFEAVGEISTLREILSDGHRALVVGHADEERIVWLAEPLVSVEHLPDNEVAGPELDDDRPRRLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYSDIGGLTRQIEQIRDAVELPFLHKDLYREYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAREAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIFSKYLTEELPVNEDDLAEFGGDRSLTIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKYAIKSVLETGQKGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSANRAIDTESNLGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Mycobacterial proteasome ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: FENR1_BACVZ
Sequence: MAENHEVYDVTIIGGGPIGLFAAFYCGMRELKTKVIEFLPRLGGKVSMFFPEKIIRDIGGIPGIAGEQLITQLKEQAATFKPDIVLNQRVTGFERLEDGTIVLESSEGEKHYTRTVILAVGMGTLEVNELDSADASRYSGKNLHYKVEKLDAFRDKHVVISGGGDTAVDWANELEPIAASVTVLHRREEFGGLESSVAKMKRSSVRVLAPYRLKHLNGTGERIESVTICQTESGLSEVIKLDELVINHGFKIDLGPMKDWGLEIEEGRIKADRHMRTNLPGVFVAGDAAHYESKLRLIAGGFTEGPTAVNSAKAYLDPQADQMAMYSTHHKKLVTQ
What are the official names of this protein?
Ferredoxin--NADP reductase 1, FNR 1, Fd-NADP(+) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: QUEC_PSEAE
Sequence: MNQKKAVILLSGGLDSATVVAMAKADGYACYTMSFDYGQRHRAELQAAERVARQLGVIEHKVIGLDLNGMGGSALTDESIAVPESPSEGIPVTYVPARNTVFLSLALGWAEVLDARDIFIGVNAVDYSGYPDCRPEFVEAFERMANLATKAGVEGNGFRIQAPLQYLSKAQIIQAGVARGVDYGLTVSCYQADEQGRACGKCDSCRLRADGFAAAGISDPTPYF
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RRP36_CRYNJ
Sequence: MFADLNSLPLSTLAKAQKSLSRKSSSSSSNGRSKEEKLALMKSKLAQMQRSKGKAVAVPDTDSHRFGSRAQESDEESDSGPETTSSTKRGSKHAPAALSTKKQVSRKRQVIEVPKPERRDPRFSSVSAGHANADLHSKSYSFLPDLLRQEFSGLKEAVAAAKKAEKNCPWAEKPMRTAERERLEVQMGQVRTKLVRTEKEAMEREVLAKAKKEEREKRTQGKAAWFMKKGESPKCEKKDLLLKARFETLEKQGGKTAVKKLVEKKRKKLASKEKKSRPFAKGAEGMGRDTKRRRVA
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS7_MARSD
Sequence: MSQRSAAIARTTKETDISLKLNIDGEGNTNIDTGVGFADHMLTLMSFWAGFDLDLKCKGDLEIDSHHTLEDIALVLGQVLSEAMGDKKGINRIGFAKVPMDEALVEVVIDLSGRAYLVYDDDILPPIIAGDERDVWREFFKSLAFKAGMNLHIKFEYGRNGHHLLEGAFKALGLAFRNALSVERQGVSSTKGSLD
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_SYNP6
Sequence: MQFIDHATICVKAGDGGDGIVAFRREKYVPAGGPSGGNGGRGGSVILVATEQLQTLLDFRYLRLFKAQDGERGGPKGMTGASADDLIIQVPCGTAVYDAETDECLGDLTSAGQTLQVAQGGKGGLGNQHFLSNSNRAPEHALPGLPGEERQLRLELKLLAEVGLIGLPNAGKSMLISVLSAAKPKIADYPFTTLVPNLGVVRRETGDGTVFADIPGLIEGAHRGAGLGHDFLRHIERTRLLIHLVDLTAEDPIADWRTIQAELKAYGRGLSDRPQILALNKIDAVLDEDLSFWQAEFQALTPVPLLCISSADRRGLDALLRLVWQWLDELDAAAELSETRVLN
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC35_ARATH
Sequence: MSHFGRSGPPDISDTYSLLVLNITFRTTADDLYPLFAKYGKVVDVFIPRDRRTGDSRGFAFVRYKYKDEAHKAVERLDGRVVDGREITVQFAKYGPNAEKISKGRVVEPPPKSRRSRSRSPRRSRSPRRSRSPPRRRSPRRSRSPRRRSRDDYREKDYRKRSRSRSYDRRERHEEKDRDHRRRTRSRSASPDEKRRVRGRYDNESRSHSRSLSASPARRSPRSSSPQKTSPAREVSPDKRSNERSPSPRRSLSPRSPALQKASPSKEMSPERRSNERSPSPGSPAPLRKVDAASRSQSPYAAE
What is the function of this protein?
Probably involved in intron recognition and spliceosome assembly, but not involved in alternative splicing regulation of the SCL33 intron.
What are the official names of this protein?
Serine/arginine-rich splicing factor SC35, At-SC35, AtSC35, SC35-like splicing factor.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family. SC subfamily.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: TPC2L_RAT
Sequence: MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMMVQVC
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 2-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. Sedlin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.