PharMolix/UniProtQA huggingface dataset:
Protein: RL13_SYNP2
Sequence: MIKTPLPKQETLDQKWYVVDAADQRLGRLASEVAKVLRGKNKAEYTPHMDTGDFVIVVNAEKVVVTGRKPEQKLYRRHSGRPGGMKVETFNQLQDRIPERIIEKAVKGMLPKNALGRRLFTKLKVYAGTEHPHAAQQPEVLTINTIPGGDN
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SP110_ZYGRC
Sequence: MADAPDHSLNGRRHLEFTPIGYSRQNPLKRLSRSPIQTVAEDDNNGNGMSEEGPFKKQRRADLDDTIASHRMFNDSSQFDDTLPQLNGQSADNDNDNAHDSGKETDDVVKNLMGNLKENAPASNPLKEQQEQLHKLNTDNYNLRLKCNSLLKFLHNVTDQGELTKSLGLLDEIHEWKQKHYTLNQQYLELKAKLIQVEANAAENKQEPVTEVDHTACQRELSYVQNQLEKTTLQLNTYRDEVAHLEDKTIRIQEDQRAKEEQHQLEIQMLRSDVNNLNVSLVNKESELEEDRAKIQRLMNQLHEFDHKGSQSLLDLERQLEMKRDSISSLEKEVRALTHDRVHLETRIKDREIENAKIQSELERLRDNVKNNNSSNFEIGELKHAKASLDDKVRNLTEERHNLNQRISALRKECDEWKSKYQRNESLDSNHRKAFDSLRQELQTTKTQLEETRKTAQQLQTQVIENTTKNSERTSQRIKDKETQIQKLESELQFCKQQLKDGSRRLQAEEERCRETFESELQNLEMKNGFERTKLEREITLLKEERVALIETHDRELELWKSKCDALNKENDILVRQEIGDLDGVKRKLSQQLDKLQEKLTTAEGERGDLAEKLIKLQHSKDSYKDELKRVSSKLEYLSKEYLKSKQSAINDDEQKTKYNTMKQRLLVELKSLQDENLSLERKLLEQRGSSSRSQESSSRSSSTTQDRLDYYKLKYNNEVKHNNDLRIMNDYLNRVLRASSQHLKLDLLKLESEISQPAVPSSRTYKTVLDDDRYRPRFRSGLISPGHIPTFKAVALLVLACVRMKQTAVRCRWDEHRIRYLRNKMAIDDDRITW
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Potential role in cross-linking filaments or anchoring other molecules.  It is essential for growth (By similarity).
What are the official names of this protein?
Spindle pole body component 110, Spindle pole body spacer protein SPC110.
What is the protein family that this protein belongs to?
Belongs to the SPC110 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Tightly associated with the nucleus. It is present in a granular pattern that excludes the nucleolus.
Protein: PYRC_LISIN
Sequence: MYVLKNGQVLNESGELENKDVLIQNGKVNLIADSIEVTSGEEFDATGKLIAPGFIDVHVHLREPGGEHKETILTGTKAAARGGYTTICSMPNTKPVPDSKEVMNSLQAKIKETAEVRVLPYASITTSLGTDELVDFEALKEAGAFAFTDDGVGVQLAGTMYEAMKRAAALDMAIVAHCEDNSLIYGGVVHDGIFAEKEGLKGIPNIAESVQIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVSPHHLILDEEDIPGNDGNWKMNPPLRSKEDRAALLEGLLDGTIDFIATDHAPHAAEEKNVPMEQAAFGIVGLETAFPLLYTHFVKTNEWTLKQLIDWMTVKPAECFKLPYGKLEEGAVADIVVLDLEKEATIDPATFYSKGKNTPFVGETCIGWPVATFAEGELVYNEGENK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: PANB_ANAMF
Sequence: MLLNILDIQAKKGLEKIACLTAYTFPMARILDEHCDLILVGDSVGQTVYGMESTLSVTLDIMIAHGKAVVKARSKALVVVDMPFASYYTPELAYKNASRILSETGCDAVKLEGGVCVAEEIAFLVARGIPVMGHVGLMPQHFNQLGGYKCQGKTDSSRQHIKEDAKAVCEAGAFCVVLECISPSLAAELTQELPVPTIGIGASNACDGQILVVDDMLGQSSRYPKFVKRFADLEHTIKDAVVGYVRAVKCSEFPGDEHCYSDGPHLRVFRAHPHHAQ
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTMP_SHEEP
Sequence: MSHRRMQLALSLVFILCGLFNSIFCEKQQHSQQHANLVLLKKISAFSQKMEAHPKAFAQELFKALIAENPKKNIIFSPAAMTITLATLSLGIKSTMSTNHPEDLELELKLLDAHKCLHHLVHLGRELVKQKQLRHQDILFLNSKMMANQMLLHQIRKLQKMDIQMIDFSDTEKAKKAISHHVAEKTHTKIRDLITDLNPETILCLVNHIFFKGILKRAFQPNLTQKEDFFLNDKTKVQVDMMRKTEQMLYSRSEELFATMVKMPFKGNVSLILMLPDAGHFDNALKKLTAKRAKLQKISNFRLVHLTLPKFKITFDINFKHLLPKINLKHLLPKIDPKHTLTTTASSQHVTLKAPLPNLEALHQVEIELSEHALTTDTAIHTDNLLKVPANTKEVPVVVKFNRPFLLFVEDEITQTDLFVGQVLNPQVE
What are the official names of this protein?
Uterine milk protein, UTMP.
What is the protein family that this protein belongs to?
Belongs to the serpin family. UTMP subfamily.
Protein: NNRE_TRURR
Sequence: MSAAQARHLTTLATGRYGFELQTLMERAGESLAGLAAHLAPDGPVLVVAGRGHNGGVGLAAAHCLARARRAVWVVPTHEAENYSGVPKELLERLAELPNVRLRSSLPKMKFSCALDAAVGMRLEGPPRGRTLDVITVLNNLGCKVLSLDVPTGLAADSGEVPGDVVRASATLALALPKPGTPPGGVVGDLYLASFDLPEALFHDVGLEPFVAPSPWARIV
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: NU1C_MARPO
Sequence: MISNINLEDKFFSFFFTLGFSKEFFNFLWIIFSILILMLGVTIGVLVLVWLERKISAAIQQRIGPEYAGPLGIIQALADGIKLFLKEDIVPAQGDVWLFNIGPILVLIPVFLSYLVIPFEYNVILANFSIGVFFWIAVSSVVPLGLLMAGYGSNNKYSFLGGLRAAAQSISYEIPLALSVLSIALLSNSLSTVDIVEAQSKYGFLSWNLWRQPIGFIVFFIASLAECERLPFDLPEAEEELVAGYQTEYSGMKFAFFYLASYLNLLVSSLFVTILYLGGWHFSIPFFSLFKNFEWNLMSNGISEVISIIIGIVITLVKSYLFLFISIMTRWTLPRIRIDQLLNLGWKFLLPIALGNLLLTTSFQLFLL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DNAK_RHIWR
Sequence: MAKVIGIDLGTTNSCVAVMEGGKPKVIENAEGARTTPSIVAFAKDGERLIGQPAKRQAVTNPDNTIFAVKRLIGRRFDDPITRKDTELVPYHIVKGPNGDAWVQAGGEDYSPSQISAFTLQKMKETAESYLGETVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLEKNDGKTIAVYDLGGGTFDISILEIGDGVFEVKSTNGDTFLGGEDFDAKLVEFFAADFQKAEGIDLTKDRLALQRLKEAAEKAKIELSSAQTTEVNLPFITADATGPKHLVKSLTRADLERLVEPLIQRSIEPVKKALADAGLKAADIDEVVMVGGMTRMPKVREVVKSYFGKEPHTGVNPDEVVAMGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRMIDRNTTIPTKKSQTYSTADDNQNAVTIRVFQGEREMAADNKMLGQFDLIGIPPAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEQQIKIQASGGLSDADIDGMVKDAEKFAEEDKKRRAAAEAKNNAESLIHTTERQLQEHGDKVDGGLKSEIEAAIADAKTAVEGGDADAMTEKAQALAQVAMKLGQAIYEKEQAAAAAPGEEAPKDDDVVDAEFSEVDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ACP_YERPY
Sequence: MSTIEERVKKIIVEQLGVKEDEVKNSASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDFINANQQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_THERP
Sequence: MDRPPMVCLVVLDGWAIGPDYPGNAIRAAHTPVMDRLQATYPMTTLRCWGRDVGLPDDQMGNSEVGHLNLGAGRIVYQLITRIDLAIEDGSFFQNEAFQRALDRARQPGRTLHLMGLIGDGGVHSHQRHLLALLELAARAGISRVAVHAFTDGRDTAPTSGIEHLRELLAALDRLRTGFVATVSGRYYAMDRDKRWERTKLAYDAIVCGLGQTARSPLEAIERSYAQGITDEFIVPTVIVDAEGKPLATINDGDAVIFFNFRADRARQLTQALTDAGGFTAFPRCRWPRDLLMVTMAEYEPHFPVLVAFAPDIVRVPLARVLSDVGLRQFHTAETEKYAHVTYFFNGGREEPFPGEDRLLVPSPKVPTYDLKPEMSAPEVTDAAVQAIVSQRYAFVLVNYANPDMVGHTGVFAAAVAAVECVDRCLGRIEQAVRSVNGYLVVTADHGNADEMLVPGTNEVWTAHTKNPVPFILVAPNHSPFRSVALRTGGRLADVAPTILEIMGLPQPEEMTGRSLIVAPSVGR
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: NTPP_SYNJA
Sequence: MLPPIVLASQSPARRQLLEAARIPFRVQPSYFDESQIQSPDPVELVQKLAAAKAEAVAAQQREPVLVIGADSVLYLGGEILGKPANALEAERRLRQMRGEVGELYTGHALIDTRQNRRLVHYAVTRVFFAKPSDEEIRTYVATGEPLNCAGCFAIDGRGSLFVERIEGCPGNVIGLSLPLLRRMIQELGYSLTEAWN
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_NOSP7
Sequence: MKLLFIWLIRGYRMFISPLFLPTCRFQPTCSMYAIEAIERFGVLRGSWMATRRILRCHPFHPGGYDPVPEVVEKVKEE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NART_STAEQ
Sequence: MNMKKGVSQLTLQTLSLVAGFMAWSIISPLMPFISQDVDISPGQISVILAIPVILGSVLRVPFGYLTNIVGAKWVFFWSFIVLLLPIFLLGQAQSPGMLMLSGFFLGIGGAIFSVGVTSVPKYFSKDKVGLANGIYGVGNIGTAVSSFCAPVLAGAIGWQNTVRSYLIILSIFAILMFFLGDKNEPKVKIPLMAQVKDLSKNYKLYYLSLWYFITFGAFVAFGIFLPNFLVDHFSIDKVDAGIRSGIFIALATFLRPVGGVIGDKFNAVQALIIDFVIMIIGALILSLSSHIVLFTIGCLAISICAGIGNGLIFKLAPSYFSKEAGSANGIVSMMGGLGGFFPPLVITFVTSITGSSHLAFFFLAIFGVIALITMIHLNKKEKAIRI
What is the function of this protein?
Probably required for nitrate uptake under anoxic conditions.  Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity).
What are the official names of this protein?
Probable nitrate transporter NarT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VANR_ENTFC
Sequence: MSDKILIVDDEHEIADLVELYLKNENYTVFKYYTAKEALECIDKSEIDLAILDIMLPGTSGLTICQKIRDKHTYPIIMLTGKDTEVDKITGLTIGADDYITKPFRPLELIARVKAQLRRYKKFSGVKEQNENVIVHSGLVINVNTHECYLNEKQLSLTPTEFSILRILCENKGNVVSSELLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTIDNPKYIKTVWGVGYKIEK
What is the function of this protein?
Member of the two-component regulatory system VanS/VanR.  Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance.
What are the official names of this protein?
Regulatory protein VanR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXB_PEPAC
Sequence: MENVYDLAIIGSGPAGLAAALYGARAKMKTIMIEGQKVGGQIVITHEVANYPGSVREATGPSLIERMEEQANEFGAEKVMDKIVDVDLDGKIKVIKGEKAEYKAKSVILATGAAPRLAGCPGEQELTGKGVSYCATCDADFFEDMEVFVVGGGDTAVEEAMYLAKFARKVTIVHRRDELRAAKSIQEKAFKNPKLDFMWNSAIEEIKGDGIVESAVFKNLVTGETTEYFANEEDGTFGIFVFIGYIPKSDVFKGKITLDDAGYIITDDNMKTNVEGVFAAGDIRVKSLRQVVTACADGAIAATQAEKYVEANFEE
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTND_CROS8
Sequence: MSALTIFADNGASEPLWQSTDADAIREQLNAQGVRFERWQADRELGDNPTPETVLTAYQHAIDLLVAEKGYQSWDVISMRADNPQKEALRDKFLNEHTHGEDEVRFFVEGAGLFCLHIGDKVYQVLCEKNDLISVPAGTPHWFDMGSEPHFTAIRIFDNPEGWIANFTGSPIAEAYPRLA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: GCTB_ACIFV
Sequence: MADYTNYTNKEMQAVTIAKQIKNGQVVTVGTGLPLIGASVAKRVYAPDCHIIVESGLMDCSPVEVPRSVGDLRFMAHCGCIWPNVRFVGFEINEYLHKANRLIAFIGGAQIDPYGNVNSTSIGDYHHPKTRFTGSGGANGIATYSNTIIMMQHEKRRFMNKIDYVTSPGWIDGPGGRERLGLPGDVGPQLVVTDKGILKFDEKTKRMYLAAYYPTSSPEDVLENTGFDLDVSKAVELEAPDPAVIKLIREEIDPGQAFIQVPTEAK
What is the function of this protein?
Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
What are the official names of this protein?
Glutaconate CoA-transferase subunit B, GCT small subunit.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFL9_SCHPO
Sequence: MNVVKYIIFSFALAPLLLVNANTYNFTQIQKRSVNQAVLESSQDTNSVGGEASSTACPLFTTIYTNGITPGTTTIYPTSISTSGVSSNNIDETSVSSESIITSTITTTITSGSQLYTTTITGQNTPVDTVEVVIPTAGTFTTTLTSGSSYPVATTTVRTASGTQSGEVEVITPSCGCSPENSFHLKIDNDKISPSYVYMDPNAPVRTNGAGREGNMFASTNGDNEGLNLFYYDSTIQRVLTCDCQRPSYTVYIEDPIIGNGFSSAWNLIKNSDGIFTPVESRNNEPLHFHVDNNGRVWMTSQEYDTEVSSTDERNFRANDVTLQLY
What is the function of this protein?
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity).  Induces flocculation when overexpressed (PubMed:23236291).
What are the official names of this protein?
Putative cell agglutination protein pfl9, Adhesin pfl9, Pombe flocculin 9.
What is the protein family that this protein belongs to?
Belongs to the mam3/map4 family.
What are the subcellular locations of this protein?
Cell surface.
Protein: UBTD1_HUMAN
Sequence: MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD
What is the function of this protein?
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.  Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.
What are the official names of this protein?
Ubiquitin domain-containing protein 1.
Protein: CS3_COFCA
Sequence: MELQEVLHMNGGEGEASYAKNSSFNQLVLAKVKPVLEQCVRELLRANLPNINKCIKVADLGCASGPNTLLTVRDTVQSIDKVRQEMKNELERPTIQVFLTDLFQNDFNSVFMLLPSLYRKLEKENGRKIGSCLIAAMPGSFHGRLFPEESMHFLHSSYSLQFLSQVPSGLVTELGITANKRSIYSSKASPPPVQKAYLDQFTKDFTTFLRMRSEELLSRGRMLLTCICKGDECDGPNTMDLLEMAINDLVVEGRLGEEKLDSFNVPIYTASVEEVKCMVEEEGSFEILYLQTFKLRYDAGFSIDDDCQVRSHSPEYSDEHARAAHVASLIRSVYEPILASHFGEAIIPDIFHRFATNAAKVIRLGKGFYNNLIISLAKKPEKSDV
What is the function of this protein?
May be involved in the biosynthesis of caffeine.
What are the official names of this protein?
Probable caffeine synthase MTL, Methyltransferase-like protein.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: HBB_CEPBA
Sequence: VHLTADEKAAVTALWGKVDVEDVGGEALGRLLVVYPWTQRFFDSFGDLSTPAAVMGNAKVKAHGKKVLNAFSEGMAHLDNLKGTFAKLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: Y695_LEPCP
Sequence: MKDLPAAMRPREKLLALGPAALADAELLALLLRTGLKGTGVLQLAGQLLAQFGGIGGLLQADPAGLKTVKGLGPAKRSELQAVLELARRAIVSQLAQRPVFDSPQAVRDYLRLQLGRLDHEVFAVLFLDAQHRLIAYEPLFRGTLTQTSVYPREVLKRALALNAAALILAHNHPSGVAEPSRADEFLTQSLKTALALIDVRVLDHFVVGRESVVSFAERGLL
What are the official names of this protein?
UPF0758 protein Lcho_0695.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: UBE2T_XENLA
Sequence: MQRVSRLKRELQLLNKEPPPGVICWQNESNMDDLRAQIIGGSGSPYEGGIFNLEIIVPERYPFEPPKIRFLTPIYHPNIDSAGRICLDILKLPPKGAWRPALNISTVLTSIQLLMSEPNPDDPLMADISSEFKYNRAVFFSNAKKWTEKHALPAPQGSDKESQEKSGSSEGTSHKRKSAEIAEESKKPCREP
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Catalyzes monoubiquitination.  Involved in DNA repair.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 T, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates to chromatin.
Protein: NPD_YERPE
Sequence: MRIRHRLCRFRKSKHVRHQRFRSRIFHRDSAVAKEMKKPFVVVLTGAGISAESGIRTFRADDGLWEDHRVEDVATPEGYRRDPELVQRFYNERRRQLQQPDIAPNAAHFALADLEAVLGDNLVLITQNIDNLHERAGSKRVIHMHGELLKVRCTQSGQVLDWQGDLSADERCHCCQFPSPLRPHIVWFGEMPMGMDDIYQALAEADFFISIGTSGHVYPAAGFVHESHLHGAHTVELNLEPSQVESQFDEKHYGLASKVVPEYIREFLTTCGENRQGD
What is the function of this protein?
NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins.  Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPCI_ASPFU
Sequence: MATASQIRLRPRLGVARATDTNPDGALEAANRLLQKNHNEHHMFWRSVAGHNHVAHSVLNTLALGGGPGDLQRAFDDGAEIQVPIPPMDRDAAASLSTPDQFRARMGSLEQYPNFLVFFTKEIETRGYPAVVIEYCFSGTSIAESMFANLFEGLYHPLIHLALGIEFDQPSIVAEGLAQAACHDSMNIEPFLFGTDKLAKTQDAPIDLNTPLLSLFHAVRDNEVLRAAAHRDHGDGVARVRDGILGRAREEISLIAARFRVDVDELDHRAAEMISCAAYLAGSAQRPGKARKIDFFHLHAVTASLGLIVLLQQPWVTPEQKARLIEWKARVDLVWYAASGAVELRRKDIVDYRPRHGLTWDSLYQAVRRVHDDGHLAKFIRALKAGEQISRPFEQGKRAEAFPIKGSMWLRIAQMAYDSSAGRPIEEKWIWGAGFEPNWATVPAV
What is the function of this protein?
Questin oxidase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966).  The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966).  The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966).  The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966).  Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966).  Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity).  Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH.  Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966).  Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death (PubMed:22319557).  The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
What are the official names of this protein?
Questin oxidase, Trypacidin synthesis protein K.
What is the protein family that this protein belongs to?
Belongs to the questin oxidase family.
Protein: IRC8_YEAST
Sequence: MCHNSVRSGNKAGFLGIKFGSALLSIATGAIAIALLCKFHDHEAVLIVIVCSTLLYGIPSLISFITETVFAPSKFHIGYFYNVLNFALPLITMGCTVDYFHNTLRSPISVQSESHRVYITTLDSLLIFTLFINGIQLGFFLKDGNANNFGSSSNNISTDQYDKEANAVENGRFVPLKNSSQTLTPDLELLHGSPKSMNGVAWLINELSTNSNTNANKTISSDENSNSSVIRHKLGPISTSKCPKKPSHSHFSKLKKYNSFFLGPKENRYKRNTQQATKVPTEKKSNHRSSQYVSRLSTISDISKSFLNFLALNEKNGNSTSTARTPSEGRVSIIINEGNNTLKYKTPHDSHTIDSPNLELEREAIGRINSALLPACLRVTDKMISPQQSTQNEDSYQATPLIPQVEVDDDFYVGDILMTNELQDIPQVPRISSDIEDDFEQQYTKHVDLPARVTLEMWEKDQEKILQKVTTNRDKSKLLPPFRFTSESDMDPSTSTELEVELHAQNNFSFPFKSAGLQIATSDQFNQQEFKTSDTISELDEYLHDPSIQEEDASQLIESSLNQNNLSSTTIDNGPKDMSRFSTRHSPTKSIISMISGSGSVKHQHSHSTLSNFFTGHSRNNSQINQLLQGSSSNMMSNTSPHSSPTKSLRMRFGKKLSLSNISDTMSPYEGSTTDPINYSFGHGHNKNQSIDFSYVRTLQSSHSPTKSTSGNSRRDSLNNDRTQSTVNERALRTASTLFYLQHNNATCTLNGEEPVLDTPQSIQSSSSGSEQESAGSGSGYPEVVFSEYDREKWNVLRNLKEIAPEKTIESGPVEELVSPSK
What are the official names of this protein?
Uncharacterized protein IRC8, Increased recombination centers protein 8.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IDI2_BACAA
Sequence: MVRAKRKLDHIEYALSTGQSRTHGFHDIEFVHQSLPNSSYETITCETKIGELSLSSPIFINAMTGGGGEKTLHINEQLAYVAKHHNLAMAVGSQMAALKDESEAASYKIIRKVNPNGIFFANLGSEATVEQAERAVDMVGANALQIHLNVIQELTMPEGDRDFTGVLQRIEEIVLNSKVPVIVKEVGFGMSKETMQQLASVGVTAIDIGGQGGTNFAAVENERRQRMLSYFNNWGIQTATSIIEATSTNNNLSFIASGGIQTALDVAKAIALGANTTAFAGYFLRILMEDGIEKLVDEIDLLHTDLKFIMTALGAKTIEELQSVPLVIKGETYHWLTQRGIDTTHYSRR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_STUS1
Sequence: MTRTVNCRKYNQELPGLERPPFPGQKGEDIYNNISRQAWDDWQKHQTMLINERRLNMMNAEDRKFLQGEMDKFFSGEDYAKAEGYVPPSE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.