PharMolix/UniProtQA huggingface dataset:
Protein: ZKSC3_MOUSE
Sequence: MARESRESTTLDSHSAEDQMELLVIKVEQEESSPLAEETSWLGSPGPDRSRQRFRAFRYPEAAGPRQALSRLRELCRQWLRPDMHSKEQILELLVLEQFLTILPGELQAWVREQHPDSGEEVVALLEYLDRQLDDTPPQVPDDDDGQELLCSKAVLLTSAQGSESSQMEPVEPLLKQESLGSLPSEVRVTHVGHCGEDGVTATRLTSELQGLLKMEDVAPVLSPRWTEQDSSQMNLYKDGMQEHSGSLVSLDQDMQTKVRDLPRAEEYRDQKPEQTVCFLGEDTVPIPTGAEASEQEGKLQAAQKSATGTRRFYCRECGKSFAQSSGLSKHKRIHTGLKPYECEECGKAFIGSSALIIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFTQSCSLLEHHRIHTGEKPYQCNMCPKAFRRSSHLLRHQRTHTGDKDFFVPEPYWESQSRVESHWENIETPVSYQCNDCERSFSRITSLIEHQKVHTGEKPFECQTCGKGFTRPSYLIQHQRRHTGKKTSVTVTPAVHSEVGVQLSLN
What is the function of this protein?
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy.  Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2.  Associates with chromatin at the ITGB4 and VEGF promoters (By similarity).
What are the official names of this protein?
Zinc finger protein with KRAB and SCAN domains 3, SCAN-KRAB-zinc finger protein, Zinc finger protein 306, Zinc finger protein 307, Zinc finger protein 47 homolog, Zf47, Zfp-47.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function (By similarity).
Protein: MMP24_RAT
Sequence: MPRSRGGRAAPGQAARWSGWRAPGRLLPLLPALCCLAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTIDDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKTGPQPVTYYKRPVQEWV
What is the function of this protein?
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence.  Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia.  Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence.  May play a role in axonal growth.  Able to activate progelatinase A.  May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.  Cleaves partially fibronectin, but not collagen type I, nor laminin.
What are the official names of this protein?
Matrix metalloproteinase-24, MMP-24, Membrane-type matrix metalloproteinase 5, MT-MMP 5, MTMMP5, Membrane-type-5 matrix metalloproteinase, MT5-MMP, MT5MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
[Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. SUBCELLULAR LOCATION: [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.
Protein: UXAC_SHIFL
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: HIS3_THISH
Sequence: MSPDWLDTIHWNPDGLIPAIAQETGTGKVLMLAWMNRESLQRTLETGEAVYWSRSRQRLWHKGESSGNTQRVVQMRLDCDRDTLLLEVEQRGGIACHTGRHNCFYHRYQDGDWQVVEPVLKDPDQMYGDKT
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_ECOLI
Sequence: MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNLDFVGGAE
What is the function of this protein?
One of the early assembly proteins, it binds 23S rRNA; is essential for growth.  One of the proteins that surround the polypeptide exit tunnel on the outside of the subunit.  Acts as the docking site for trigger factor (PubMed:12226666) for Ffh binding to the ribosome (SRP54) (PubMed:12756233, PubMed:12702815) and to nascent polypeptide chains (PubMed:12756233).
What are the official names of this protein?
50S ribosomal protein L23, Large ribosomal subunit protein uL23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PUP_STRCO
Sequence: MATKDTGGGQQKATRSTEEVEEQAQDAQASEDLKERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGE
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: YLBE_ECOLI
Sequence: MFTSVAQANAAVIEQIRRARPHWLDVQPASSLISELNEGKTLLHAGPPMRWQEMTGPMKGACVGACLFEGWAKDEAQALAILEQGEVNFIPCHHVNAVGPMGGITSASMPMLVVENVTDGNRAYCNLNEGIGKVMRFGAYGEDVLTRHRWMRDVLMPVLSAALGRMERGIDLTAMMAQGITMGDEFHQRNIASSALLMRALAPQIARLDHDKQHIAEVMDFLSVTDQFFLNLAMAYCKAAMDAGAMIRAGSIVTAMTRNGNMFGIRVSGLGERWFTAPVNTPQGLFFTGFSQEQANPDMGDSAITETFGIGGAAMIAAPGVTRFVGAGGMEAARAVSEEMAEIYLERNMQLQIPSWDFQGACLGLDIRRVVETGITPLINTGIAHKEAGIGQIGAGTVRAPLACFEQALEALAESMGIG
What are the official names of this protein?
Uncharacterized protein YlbE.
What is the protein family that this protein belongs to?
To E.coli YahG.
Protein: RL20_GEMAT
Sequence: MPRVKSNVVRLKRKKQILKHAKGAFGGRSKLWKAAKETVERGWRYAYRDRKNKKRDFRRLWIVRINAAARLHDMSYNAFINGLHASGIEVDRKVLADLAVREPEAFAAIAEQAKKALDAKVAAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: YPP1_ASHGO
Sequence: MSLEMDLIEWALNLRAAGGGVFGSGSEELDRVLKLHYRVTYHAFDRGTKRSVWEVLLAEAEKIDSSKGMELEQAVMGNVFGILYRQLGDETECARWLAKLGALRALRGEYPEFWALLLLENVCYREAIGVEDQQQVFRDVARLPKETHTLTWFYLERFLARVQCERWQAVKEFGGVPLAYLLEAVREEEGVDQWLLEQGRAILSRTRFPAASEKNSTMLEEFHAVLNYYLRKNNKPRSTEWEGFITDSLGVTFQSVNVSKAALTYYRRFGDTKLALLNLLNFFNYSERFRRMNNGFYDDIVSLLDAYTFVLQLTSLPEAIGDIFNKAKAFEQLRNILQEFYRDYRLQQIPKEHSADWLSNSAKVVVPPKLARLLSDSWFLLYRIERNSLKPTLDFSLTYYLANAMCINPLNIDVKFHYAYVLASIRRIDMCIRFLKTNILNIKPADYRSWHLLALCESIQEDKDVSFKIVCSVLKAMAEAHEESNLLKADKWQFIHIKLTQLVLVKEMFGVKDALEMLSEVYQLYASLFPASKVNKTKDESRLGPAHNQTKEYLFQAIWFFSARLFLQDGDAQNAREAIDEAKRVTDTFTNLNVNITHGYLKLHCDPKGAMSEFQNALSFDPTNVDAVVGLAKLLYPEDQGSLERIARHRPIIGTATPKPESDPFANSKDRSAAVAQLKMLLENCIEKSIDGYHTPEVWWYLSRIYDEFHDNERLESALWQCIKFHELEPIRDFKYCMF
What is the function of this protein?
Involved in endocytosis.
What are the official names of this protein?
Cargo-transport protein YPP1.
What is the protein family that this protein belongs to?
Belongs to the YPP1 family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PROB_CORML
Sequence: MRERISNAKRVVVKIGSSSLTNDEDGHTVDPNRINTIVNALQARMEAGSDLIVVSSGAVAAGMAPLGLSTRPTELAVKQAAAAVGQVHLMHQWGRSFARYGRPIGQVLLTAADAGKRDRARNAQRTIDKLRILGAVPIVNENDTVATTGVNFGDNDRLAAIVAHLVSADALVLLSDVDGLFDKNPTDPTAKFISEVRDGNDLKGVIAGDGGKVGTGGMASKVSAARLASRSGVPVLLTSAANIGPALEDAQVGTVFHPKDNRLSAWKFWALYAADTAGKIRLDDGAVEAVTSGGKSLLAVGITEIIGDFQQGEIVEILGPAGQIIGRGEVSYDSDTLQSMVGMQTQDLPDGMQRPVVHADYLSNYASRA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCA1_SCHPO
Sequence: MSYNSNPYNGGQYPPYNTYTRPNYSPNNGSQSNNTVHQYQPPRMPPPSTRPQTDGNSNQIPMENVGHISLSSANSHAYAPPSGPPPNTGANSYGNPNYSGPQLPNTQTQSYNLAGGGNFQYQYSTCQGKRKALLIGINYLNTQNELQGCINDVMSMSQLLIQRYGYKQEDMVIMTDTASNQRAIPTRQNMLDAMRWLVSDAQPNDALFFHYSGHGGQTKDLDGDEVDGYDETIYPLDHQYAGQIIDDEMHEIMVKPLPAGCRLTALFDSCHSGGALDLPFTYSTKGVLKEPNMLKESGMDVLHAGLSYASGDIMGAINNVKNIFTSATNGFNNNALQYSRQVKFSPADVISLSGCKDNQTSADTSVNGFATGALSYAFREVVTQNPQLSYLQLLRGIRQVLSNKYSQLPQLSCSHPLDMNLAMVL
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: OTC_CERS4
Sequence: MNHFLDIHKTDTAELRQMMDSAHAMKAARKGRPKGQLDEDQPLAGRMVALIFEKPSTRTRVSFDVGVRQMGGQTMVLSGKEMQLGHGETIADTARVLSRYVDLIMIRTFEEATLLEMAEHATVPVINGLTNRTHPCQIMADVMTYEEHRGPIAGRKVVWAGDGNNVCASFLHAAGQFGFDFTFTGPSTLDPEAEFVGYAREKGRRVSIERDPAKAVAGADLVVTDTWVSMHDPQSARERRHNQLRPYQVNETLMAQAKPDALFMHCLPAHRDDEATSAVMDGPHSVIFDEAENRLHAQKAIMRWCLGL
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACUK_ASPFC
Sequence: MKTEVNGSAPALAGDHGGVDQDTPDAGDRTEQAKHKTNGATENAPKSANAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGVGGNFYNNAMRNNMPLSRNGTTTVNTTTQQNSGSNYYPTPQSNSYNVYQDTPLTQNSFPSQSPVSPTFNMKTTPTARSNSLSSSVNQQPPSTTVSGATQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPTDSATQRGSIGRSGSTQYSTTPLTGAPGFGESPGNQQPFLFGNDPLLNEWPNSQAPNQGHLNVSGVYPQGGMMHMAKSDAPHAFAIESGPASFSSPSATTSPHINSGHDESSLSNAAVNKSTGLTANGQRPAITTPSLKHQSLQFGVKRRQRNPSTVYESVKEPYAYTNRFHNLTAFIQRRFSPQKTLQIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEIAAVGKEFSILTGWKKDVLLGKEPNLNVNTGGSSAPGSGNTSRGSFTPRSSTLETATPGRPQPVFLAELLDDDSVVEFYEDFARLAFGDSRGSVMTTCKLLKYKTKEDMELAQSDDNQRWNNHLRKGGIAGEAGMNQLGFKDGKVECAYCWTVKRDVFDIPMLIVMNVFLPCI
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis acuK.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YM8C_YEAST
Sequence: MNKLVDAHCHVITDPDNTFCGDDGGSQGTLRCVMSSNPYDWNNLKKLAGRSTSKNDICVGFGVHPWYSHLFYVGSRRDKVSHYQDVLEYKNEEQFDSLVQVLPEPLDLEEYIKREFNDTLVSVIGEIGLDKLFRLPANGFYMQNEKARLTTVKVKLSHQETVFRRFCRLARHTSKPISIHDVKCHGKLNDICNEELLTYHSVKICLHSYTGSKETLLGQWLKKFPPDRIFVSLSKWINFKDPEEGDALVRSLPSTCILTETDYPIDNPDPSYQKALTEQLQYLNAQIARAWDETLDASQAALRVYENFQKFIK
What is the function of this protein?
Putative deoxyribonuclease.
What are the official names of this protein?
Uncharacterized deoxyribonuclease YMR262W.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Protein: CRIP2_MOUSE
Sequence: MASKCPKCDKTVYFAEKVSSLGKDWHKFCLKCERCNKTLTPGGHAEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPQTEAPQVTGPIEVPVVRTEERKTSGPPKGPSKASSVTTFTGEPNMCPRCNKRVYFAEKVTSLGKDWHRPCLRCERCSKTLTPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDKDPEGTVQP
What are the official names of this protein?
Cysteine-rich protein 2, CRP-2, Heart LIM protein.
Protein: TRPB_METNO
Sequence: MTAPQTPNSFRTGPDERGRFGIFGGRFVAETLMPNILELERAYAEAKADPAFQAEMDSYLTHYVGRPSPLYFAERMSAHFGGAKIYFKREELNHTGSHKVNNVLGQILLARRMGKPRIIAETGAGQHGVATATLCARFGLKCVVYMGAVDVERQKPNVFRMKMLGAEVVPVQSGTRTLKDAMNEALRDWVTNVADTFYCIGTVAGPHPYPAMVRDFQAVIGRETKEQMLALEGRLPNSLVACIGGGSNAMGLFHPFLDDREVEIYGVEAAGRGVSTGLHAASLTGGRPGVLHGNRTYLLMNEDGQIADAHSISAGLDYPGIGPEHAWLHEMGRVTYLSATDQETLEAFRLCSLLEGIIPALEPAHALAKVAELAPTKPRDHLMVVNLSGRGDKDIPQVAEILGDAL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RL17_LEGPH
Sequence: MRHRNSGRSFSRTSSHRKAMFSNMCCSLIEHELIRTTLPKAKDLRRYIEPLITVSKSDSVASRRRAFDILRSKSAVGKLFTDLGPRFAKRPGGYIRIIKCGYRDGDNAPMAIVELMDRPVSSDDTEE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: HIS5_BLOFL
Sequence: MKIIIINTNCSNLSSVKIMLNKLGCNTIITDDPDLIIQSDKILLPGVGTANTAMKQLKKKNLIQLIKKCTQPTLGICLGMQLFGSFSNENTHTNTLNIINVPVKHMYSPTLPIPHMGWNNITILKKHDLLNGINNNHYFYFAHSYCMELNYTTIAYTNYGQPFSSVIVYKNFFGVQFHPEKSSFSGEQLIKNFLEI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URM1_CHLRE
Sequence: MVKVKIEFSGGLELLFGNQKQHDVDVPVQEGKQLTAGHLIAWTRDNMLRERPELFVKGHTVRPGILVLINECDWELSGATESTISDGDVVVFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_YERPP
Sequence: MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEGGCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RS20_VIBPA
Sequence: MANSKSAKKRAIQAEKRRQHNASRRSMMRTYMKKTVAAIEAGDKEAATAAFAVVTPILDRMATKGLIHKNKAARHKSRFAAQIKAL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SECF_RICAH
Sequence: MQIYPLRLLPNKIDFDFMNFKAVSYSFSIILSLISFIWIGIYKFNFGIDFAGGIVIEVRLDQAPDLPKMRGVLGELGIGEVVLQNFGSERDLSIRFGISSEENLMKNIELIKASLQSSFPYKFEYRKVDFVGPQVGRQLIEAGAMAMLSSFLAIMVYIWVRFEWYFGLGILIALVHDVILALGFMSITKLDFNLSTIAAVLTIIGYSVNDSVVIYDRIRENLRKYHKKNITEIINLSINETLSRTILTVITTLLANLALMLFGGEAIRSFSVLVFFGIIAGTYSSIFISAPILTMFANRKFNNKVIER
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNN_STAAB
Sequence: MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDIIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEISFEAFLEKAAVSSSQTVEALVSQL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: HEPT_APHF2
Sequence: MTNIEPVIIETRLELIGRYLDHLKKFENISLDDYLSSFEQQLITERLLQLITQAAIDINDHILSKLKSGKSYTNFEAFIELGKYQILTPELAKQIAPSSGLRNRLVHEYDDIDPNQVFMAISFALQQYPLYVRQINSYLITLEEEND
What is the function of this protein?
Toxic component of a type VII toxin-antitoxin (TA) system.  Upon cloning in E. coli inhibits cell growth for several hours; eventually cells recover and start growing.  Cleaves the last 4 nucleotides from the tRNA acceptor stem (shown in vitro with E. coli tRNA-Glu(UUC)); only cleaves intact tRNA.  Has no activity on mRNA.  Neutralized by coexpression with cognate antitoxin MntA, which is due to di-AMPylation of the RNase.
What are the official names of this protein?
tRNA nuclease HepT, Toxin HEPN, tRNA nuclease HEPN.
What is the protein family that this protein belongs to?
Belongs to the HepT RNase toxin family.
Protein: OPDL_PENO1
Sequence: MESTMRSPLPYGNACATCARAKCRCVPRNGGRGRCERCHHLNKECRAPQGRRKIQPKTLSRSVQLERKMDGLMSLLTSFGGRTDLPTPVQRQSEVQGMWRTEVESGTEDEETSASEEEYLRAFRTQRLQFLPLIHIPATTTVGDLKLQSPFLWQCISAVESKNTARQATLCVKIRELAGKRLLVDCDKSLDLLQGVLVYLAWITLHSQPHKSSLCMYSQMAIGLVFELGLNKPAPPDLSMTVSNSNAVGHMPGLEASISTRRTMHERRAVLSCFVLTSIIAQFLGRMGPLQWTSHMKQCLDILAESEESPGDRVLVQLTRTRLLVDQISHGPWSEGLYGLNSAQTLATFHLKALQSQLETIRAEIPIQLADNKPILFHLFDTELSLYEAALVKPLADEDFSSQRLDHLYACLRVVKQFFDLFFTIPPAGYTSLALPYIAQVSHCLVILFRLSTLDYPGWDKSTVKNTADILCIAEQISTRMAQVGDAIGMRSEGAYGDPFSKWGMMMQKLRSEWAIRLPDCSEVVVDRSSAESSCPSIEMGDLDCFVNWSELGWVMEGAGAGGFIQ
What is the function of this protein?
Transcription factor; part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid.
What are the official names of this protein?
Transcription factor opdL, Oxopyrrolidines biosynthesis cluster protein L.
Protein: MED28_AEDAE
Sequence: MASSSNVNGNLVDELEEAFQSCIHALTKEESATGVDKDEIKLEVDQTTLKFIDLARQMEAFFLQKRFLLSALKPDLLLKEENFDLKQEIARKDELIRKHYEKIESWKNLLSDQQNYNKPIQSLPPDMRGNLTGGVPGGPGMMPGGIGMPMQNSMQVQQMQAQQQQMQMLQAQQMQQQMQSMPIG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 28, Mediator complex subunit 28.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 28 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU5C_NUPAD
Sequence: MERTYQYAWIIPFVPLLVTMLIGLGLLLIPTATKNIRRIWAFPAVLLLSIVMVFSTKLAIQQINGSSIYEYLWSWSITSDFSLEFGYLIDPLTSIMSILITTVGIMVLIYSDNYMSHDQGYLRFFAYMSFFNTSMLGLVTSPNLIQIHIFWELVGMCSYLLIGFWFTRPIAANACQKAFVTNRVGDFGLLLGILGFYLITGSFEFQDLFEIFNDSIINNNEINSSFATLCAFLLFLGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFIGIPYIMNIISLIGLITVLLGATLALAQRDIKRSLAYSTMSQLGYIMLALGIGSYRAALFHLITHAYSKALLFLGSGSIIHSMEPIVGYSPAKSQNMVLMGGLTKYMPITKTTFFLGTLSLCGIPPLACFWSKDEIINDSWLYSPIFATIACYTAGLTAFYMFRMYLLTFEGHLRSNFKNYSGHTNSSFYSISIWGQEGSKPVSSNLLLATRNNNDKSSFSSCPFSNTYKIAGYVRNMRSSFSTHFLNKDPYTLLYPHESDNTMLFPLLILAIFTLFVGCIGIRFGQEVMEVDILSKWLTPSMKLLHQNSTEDWYKFVTNAFYSVSIAYFGIFIASVLYGSVYSDRQNLYLINSFAKMGPKMRIRLEQIINVIYNWSYNRGYIDVYYEKVFIRGIRGLAQLAHSFDRRVIDGVTNGVGVASFFLGEGIKYIGGGRISSYLFLYLACVSIVLLLVK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.