PharMolix/UniProtQA huggingface dataset:
Protein: MD12L_MOUSE
Sequence: MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLVKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPVDDSLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMIIGTNNTSIGTPSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKISNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPALSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRSPAGENSDEHYSKDHDMKMEIFSPMPGESCENINPSLSRRLSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKGTTESGVGDEGQKARKTKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILNDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFFPQGTGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNTMKNEDFGMRGLRRDGNAEDAWATSQNSKSYGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDNIAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQQHFLLYHTHTMPKPRSYYLEPLPLPPEEEEEELTSPVSQEPERKSAELSDQGKATADEEKKTKGRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLVSQPQQPSFFLQNPSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQQQVRQQQRLLQVWGREMQQPQQAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
What is the function of this protein?
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 12-like protein, Mediator complex subunit 12-like protein.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLD_POLDI
Sequence: AVAGEKLWLLPHLLKMLLTPTP
What is the function of this protein?
Antibacterial peptide.  Acts on the Mycobacterium abscessus subsp.  massiliense cell wall.  Reduces 40-50% of the bacterial load in macrophages infected with different M. abscessus strains.  Is not cytotoxic towards mammalian cells, and shows no hemolytic activity against human erythrocytes.  In vivo, reduces the bacterial load in the lungs, spleen, and liver of highly susceptible mice intravenously infected with M. abscessus.
What are the official names of this protein?
Polydim-I.
What are the subcellular locations of this protein?
Secreted.
Protein: ENV_HTL1N
Sequence: MGKFLATLILFFQFCPLILGDYSPSCCTLTIGVSSYHSKPCNPAQPVCSWTLDLLALSADQALQPPCPNLVAYSSYHATYSLYLFPHWIKKPNRNGGGYYSASYSDPCSLKCPYLGCQSWTCPYTGAVSSPYWKFQQDVNFTQEVSRLNINLHFSKCGFPFSLLVDAPGYDPIWFLNTEPSQLPPTTPPLLPHSNLDHILEPSIPWKSKLLTLVQLTLQSTNYTCIVCIDRASLSTWHVLYSPNVSVPSSSSTPLLYPSLALPAPHLTLPFNWTHCFDPQIQAIVSSPCHNSLILPPFSLSPVPTLGSRSRRAVPVAVWLVSALAIGAGVAGGITGSMSLASGKSLLHEVDKDISQLTQAIVKNHKNLLKIAQYAAQNRRGLDLLFWEQGGLCKALQEQCCFLNITNSHVSMLQERPPLENRVLTGWGLNWDLGLSQWAREALQTGITLVALLLLVILAGPCILRQLRHLPSRVRYPHYSLINPESSL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp62, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: IGF1_SUNMU
Sequence: FASAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKAARSVRAQR
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.  Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.  May play a role in synapse maturation.  Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.  Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AAUA_ALCFA
Sequence: MRWLDKFGESLSRSVAHKTSRRSVLRSVGKLMVGSAFVLPVLPVARAAGGGGSSSGADHISLNPDLANEDEVNSCDYWRHCAVDGFLCSCCGGTTTTCPPGSTPSPISWIGTCHNPHDGKDYLISYHDCCGKTACGRCQCNTQTRERPGYEFFLHNDVNWCMANENSTFHCTTSVLVGLAKN
What is the function of this protein?
Oxidizes primary aromatic amines and, more slowly, some long-chain aliphatic amines, but not methylamine or ethylamine.  Uses azurin as an electron acceptor to transfer electrons from the reduced tryptophylquinone cofactor.
What are the official names of this protein?
Aralkylamine dehydrogenase light chain, Aromatic amine dehydrogenase, AADH.
What is the protein family that this protein belongs to?
Belongs to the aromatic amine dehydrogenase light chain family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GUDX_ECOLI
Sequence: MATQSSPVITDMKVIPVAGHDSMLLNIGGAHNAYFTRNIVVLTDNAGHTGIGEAPGGDVIYQTLVDAIPMVLGQEVARLNKVVQQVHKGNQAADFDTFGKGAWTFELRVNAVAALEAALLDLLGKALNVPVCELLGPGKQREAITVLGYLFYIGDRTKTDLPYVENTPGNHEWYQLRHQKAMNSEAVVRLAEASQDRYGFKDFKLKGGVLPGEQEIDTVRALKKRFPDARITVDPNGAWLLDEAISLCKGLNDVLTYAEDPCGAEQGFSGREVMAEFRRATGLPVATNMIATNWREMGHAVMLNAVDIPLADPHFWTLSGAVRVAQLCDDWGLTWGCHSNNHFDISLAMFTHVGAAAPGNPTAIDTHWIWQEGDCRLTQNPLEIKNGKIAVPDAPGLGVELDWEQVQKAHEAYKRLPGGARNDAGPMQYLIPGWTFDRKRPVFGRH
What is the function of this protein?
Does not seem to have an in-vivo activity on glucarate or idarate.  Its real substrate is unknown.
What are the official names of this protein?
Glucarate dehydratase-related protein, GDH-RP, GlucDRP.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.
Protein: CEP63_RAT
Sequence: MEALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDMRDRELKALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMKLQEELSRLKRSYEKLQKKQLREFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVKDLMGTNVTILQEQRQKEEKLRESEKLLEALQEEQKELKASLQAQESFILDAKMQEKLQTKLKAVDTKHSVERSLEDCQVERKYSSSGQGVLDNVLSQLDISHSSEELLQAEVTRLEGSLESVSTTCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKTEISQLTRELHQRDITIASAKCSSSDMERQLKAEMQKAEEKAVEHKEILSQLESLRLENRRLSETVMKLELGLHECSMPVSPLGLIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV
What is the function of this protein?
Required for normal spindle assembly.  Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication.  Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned.  Also recruits CDK1 to centrosomes.  Plays a role in DNA damage response.  Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.  Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination.
What are the official names of this protein?
Centrosomal protein of 63 kDa, Cep63.
What is the protein family that this protein belongs to?
Belongs to the CEP63 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity).
Protein: CYB_MELMS
Sequence: MTNIRKTHPLTKIINNSFIDLPAPSNISAWWNFGSLLGICLILQILTGLFLAMHYSSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYMFPETWNIGIILLLAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIVSALAAVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDILGALLLILTLMVLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILAVVPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFTILLVFMPVISIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACCD_BARQU
Sequence: MNWITNYVRPKINSILRRREIPDNLWIKDPTSGEMVFHKDLEVNQYVIPNSGYHMRISAKNRLMHFFDDGIYTPLENPKVVIDPLKFRDEKRYIDRLKDYRSKLGVDDNILSAQGTIEGLPIVATVQDFAFMGGSLGMASGEAIIKAFDTAIANKCPLVLFSASGGARMQEGTLSLMQMPRTTVAIEMMKEAKLPYIVVLTNPTTGGVTASYAMLGDIHIAEPGAMIGFAGPRVIQQTIRETLPEGFQSSEYLLEHGMIDMVVSRLEMKATIARLLRLIMKCPPAVNPSNPSPTDSQPPLSKAEAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCME_GLUOX
Sequence: MTRKTRRLWIVIACLACVGSAAALTLRAFSSNIVFFMAPSQVKANPPSPDRTIRLGGMVMAGSLHRINENGTPVNAFEVTDGQAAVEVHYTGILPDLFREGQSVVALGTVQKDGGFTASEVLAKHDETYMPKEVADELKRTGKWDPRFGKAPDASSWDTMTAKKAGG
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RL6_STRGC
Sequence: MSRIGNKVIVLPAGVEITNNDNVVTVKGPKGELTREFSKDIEIRVEGTEVTLHRPNDSKEMKTIHGTTRALLNNMVIGVSEGFKKELEMRGVGYRAQLQGKKLVLAVGKSHPDEVEAPEGITFELPNPTTIVISGISKEAVGQTAAYVRSLRAPEPYKGKGIRYVGEFVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: GLMM_BURP1
Sequence: MGRRYFGTDGIRGKVGDAPITPDFVLRLGYAAGKVLASAPGRAASGARPTVLIGKDTRVSGYMLEAALEAGFSAAGVDVMLAGPMPTPGVAYLTRALRLSAGVVISASHNPYHDNGIKFFSADGNKLPDEIEAEIEAWLDKPLDCAASDGLGKARRLDDAAGRYIEFCKSTFPAAFDLRGMKLVVDCAHGAAYQVAPHVFHELGADVIPIGVAPNGFNINDGVGATAPDALMRAVRANHADLGIALDGDADRLLVVDHTGRLYNGDELLYVLVKDRIATNGQVEGAVGTLMTNFAVEVALKEAGVQFVRAAVGDRYVLEQLRERGWQLGAEGSGHILSLDRHSTGDGIVSALLVLAALKRSGKTLAQMLEGVTLFPQKLINVRMKPGADWKGSEAIRRAIDSAEQALSGSGRVLIRASGTEPVLRVMVEARQATDANRHAEAIADAVKQATA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: HIGA2_MYCTU
Sequence: MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYVSALGGELDITVRLGDETFTLA
What is the function of this protein?
Putative antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin would be HigB2.
What are the official names of this protein?
Putative antitoxin HigA2.
Protein: RT16_PONAB
Sequence: MVHLTTLLCKAYRGGHLTIRLALGGCTNRPFYRIVAAHNKCPRDGRFVEQLGSYDPLPNSHGEKLVALNLDRIRHWIGCGAHLSKPMEKLLGLAGFFPLHPMMITNAERLRRKLAREVLLASQKTDAEATDAEATET
What are the official names of this protein?
28S ribosomal protein S16, mitochondrial, MRP-S16, S16mt.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GATC_RICFE
Sequence: MITKEEAQKIAKLARLKFEEDTVEKFSAQLSTIMNMIDILNEIDCKDIEPLTSVSNMNVRMREDVVTSSDLSNKLFDNVSGNSAQLAKEVKYFITPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: GPMA_SINMW
Sequence: MSGTLVLVRHGQSDWNLKNLFTGWRDPDLTELGIEEAMAGGKALADYGIKFDIAFTSDLIRAQRTCQLVLDAVDQSSLETIRDQALNERDYGDLSGLNKDDARAKWGEEQVHIWRRSYDVPPPGGESLRDTGARVWPYYLTDILPRVLSGEKVLVAAHGNSLRSLVMVLDGLTKEQILKLNLATGVPMVYKLNADSTVASKEVLGDMSAAH
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: KCY_ECOLI
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
What is the function of this protein?
ATP, dATP, and GTP are equally effective as phosphate donors.  CMP and dCMP are the best phosphate acceptors.
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase, Protein MssA, p25.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_CORGB
Sequence: MKKDIHPDYHAVVFQDAGTGFQFLTKSTASSDRTVSWEDGNEYPLIVVDVTSESHPFWTGAQRVMDTAGRVEKFERRFGGMARRKKKA
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: MAEL_DROME
Sequence: MAPKKHSGFMMFVNEWRNRNAEGRRMTLAQAVSHCGTIWEKMNTQQRGPYNSGGKDANVAQRAKRESSNGHGQVDKAQREATESLMDMKRTIERLVLNAKMSHDLENAKFVFVAFNYFTKALTTDVYVPAEFAACEYSLKEGIRSIYSTMIDPGQIIFGQGSDALLHSSTTHDLPLPPNALGEKNMTKLYRNIVDYLSKCQGKGKTLVVFTPAENITMVKSCFRYLECDDDFRDGGEKIQVFDIQYLLFILKKEVMNVADLNDEKINKFATDAFFKKDFFEFTAGIACQYHEDNDRTKYCTQSMVTRWAYTFTDFMCGDLAITVQPGKHIPAQTKPNYLIISSYASSLDHESSFDSFYSLPGSGVKKESQPEACSLSSSRLSVASSSYKPIDHTSFAANLNEVSEFPSLGMRNSSKHHGIAASAQREWNARNLPTHSRLIRKVSDNDFSVNGADGKLKK
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage.  Indirectly required to position the microtubule organizing center in stage 2-6 oocytes.
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. Vas, aub and spn-E are required for nuage localization. Shuttles between the cytoplasm and the nucleus.
Protein: ATPF_ASHGO
Sequence: MAFRALTTKAAARPLLALGPRSVAMGARYMSTPAPQDPKSKAAAILDSLPGSTALSKTGILATSAAAAIYAISNELYVLNAETILLCTFTGFSFLIAKLVAPAYKEYADKRMQHVSGILNSSRNKHVAAVKERIESVSELKNVTETTKVLFEVSKETLELEAKAFELKQKVDLATEAKAVLDSWVRYEASVRQLQQKQIAESVIGKVQAELANPKFQDKVLQQSVADVEKLFASLK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
What are the official names of this protein?
ATP synthase subunit 4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ATPase subunit B family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: CHO2_AJEDR
Sequence: MSEQATSSGLESRSNGLRERNLQASKSAADRDVASQSLEDKLQVEEGEADTEKKTFGRTPDGTVFTVPPTRDMVSQLLSPSEPKNISDIFVLAILGCHILLLWFLPSSFRVAAFAVIFLFWRASYNIGIGWLLHMQSNGRTLVCWAKKSNIFVNPSTGQNPHPTLYKLLKWELETKISEQYSFEEAPTEYNTWLVFRRVVDLILMCDFTSYCLFAIACGGRPTGESFIMLALRWITGMSLVLFNLWVKLDAHRVVKDFAWYWGDFFYLIDQDLTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKILFISILAHAAQFAFLVLVENPHIEKTYNAPPPRKRVADTDTKPQEDENSHEGSVVSDTLSSAPVIPPLQPSSMHSLLGLHNIDLYRSTDQSVLLAQVLFFALTTLTPSTPVYQFCFVLNAALWRIWYSVGIGYILNRQSNCKMWTRHFVKYGESNHEAWRQWKGTYHLSMTMTYASFIAAAWKMYSFPQDWRYGLVLLRHILGASLIALQIWTSTSIYESLGEFGWFFGDFFFDEFPKLTYSGIYRFLNNPERVLGLAGVWGAVLITSTKSVVFLALLSHTLTLAFIQLVERPHMQKLYGQSLRRDAGLVRSLKRSLPPSLKQIHGSVDKILDDSFEFIEEFIEAARPKLAAGVQTFVKDTSALFQKYPARVTISRLEPDLAGYDLKDYSITLEGTQPSRPAQFERASDKEGERARSMPYRRGEQENLMFEYGAPIKVKWTAPLNHSKKDWVGLYMVTDNTSREVTRVSSQGRWIATNQASFDSETCEQGLISSDIVLKSSRDDGEPRDVASGEMVFSGDKLWWTQGVFEFRYHHNGKHNVMAVSRPFEICIGRFDEDDIEVDNYGLVRAAVEAALLPVVQNCFDRDPEIAPQTVEEHYGCLVDRDGKYSKRVVFAVHHMFGIEFAPEVVRADGNIRNLAWRICNAKKVLAPYSMSRSNGASTPTAAHEED
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.