PharMolix/UniProtQA huggingface dataset:
Protein: GPDA_YERPB
Sequence: MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFPDTLRLETDLACALAASRDVLVVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLLQDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTDVQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTFMGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKNAREAALTLLGRTKKDEKIGI
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_HAEI8
Sequence: MAAKIISGTELSKQIKANLADKITHYIEQGKRAPGLAVILVGADPASQIYVGNKRKSCEEVGILSKSYDLPETTTQNELLAIIDQLNADKNIDGILVQLPLPKQINAEAIIERIDPKKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHRFTKNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINRVDGKLVGDVEFDKAAEKAAYITPVPGGVGPMTVAMLMSNTLYAYEHNK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DXR_SYNJB
Sequence: MQAITLLGSTGSIGTQTLDLVAQYPERFQVVGLTSYSNVALLAEQVRRFRPQMVAIGREELLPELRSLLTGIRPLPELVAGTEGLCQVAAHPAAQRVVTGIVGCAGLLPTLAAIRAGKDIALANKETLVAGGPVVLPLVREYGVNLIPVDSEHSAIFQCLQGVPAGSLRRILLTASGGAFRDWPAEKLDQVTLADALKHPNWVMGRKITIDSATLMNKGLEVIEAHWLFGLDYDHIDILIHPQSIVHSLIELADTSVLAQLGWPDMHLPILYGLSWPERLATPWDPLDLVKLGSLTFKAPDHRKYPCMELAYAAGRRGGTLPAVLNAANEAAVALFLQERIRFLDIPRLLERVCERHQVIADPSLEDILQADAWARRETAQLAQQAPAQVLA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: CNTRL_MOUSE
Sequence: MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH
What is the function of this protein?
Involved in cell cycle progression and cytokinesis.  During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity).
What are the official names of this protein?
Centriolin, Centrosomal protein 1, Centrosomal protein of 110 kDa, Cep110.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
Protein: SAMA_SALTY
Sequence: MLLLVAPEQEPVQSTAPLFTERCPAGFPSPAADYTEEELDLNAYCIRRPAATFFVRAIGDSMKEMGLHSGDLMVVDKAEKPMQGDIVIAETDGEFTVKRLQLKPRIALLPINPAYPTLYPEELQIFGVVTAFIHKTRSTD
What is the function of this protein?
Involved in UV protection and mutation.
What are the official names of this protein?
Protein SamA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SODM_MANHA
Sequence: MAYTLPELGYAYDALEPHFDAKTMEIHHSKHHQAYINNANAALEAHPELLEKCPGALIKDLSQVPAEKRIAVRNNVGGHVNHTLFWKGLKTGTTLQGALKEAIERDFGSVEAFQSEFEKAATTRVGSGWAWLVLEEGKLAVVSTANQDNPLMGKEVAGVSGYPILVLDVWEHAYYLNYQNRRPDFIKAFWNVVNWDEAARRFEEKVATCGCAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: SYL_LEIXX
Sequence: MAHQHDTGTAAAAAGKTAIHYDFAQIQAKWLPVWEKLKPFATDDPEDNRPRKYVLDMFPYPSGDLHMGHAEAYALGDVIARYWRHQGFSVLHPIGWDAFGLPAENAAIKRGLDPRGWTYDNIAQQKASMRRYAPSFDWDRVLQTCDPSYYKWNQWLFLKLYEKGLAYRKASQVNWCPFDQTVLANEQVVNGRCERCDNLVTKKKLTQWYFRITDYADRLLDDLNQLEGAWPAKVILMQRNWIGRSTGADVQFAIEGREEPVAVYTTRPDTLYGVTFMVVAPDSELAAELAEDARPEVKQRFEEYLAAVRGTTEMDRLSTEREKTGVFLERHAVNPLTGESIPIWAADYVLSDYGHGAIMAVPAHDQRDLDFARAFDLPVRVVVDTTQPATGAVPVIKTDPQTGEPLLPESAPLESPAETGQALTGEGRLINSGPFDGLSKSNAIRRVTEALQGSGLGAPAKNFRLRDWLISRQRYWGTPIPIVHCEACGEVPVPESELPVLLPPAEGLDLQPKGRSPLGAASDWVNVSCFSCGGPAQRDTDTMDTFVDSSWYFLRFLNPNDDTRAFDPREAEKWAPVDQYVGGVTHAILHLLYSRFITKVLFDQGFVSFTEPFTVLLNQGMVLMDGSAMSKSRGNLVKLSDQLDAHGVDAVRLTMSFAGPPEDDIDWADVSPSGSAKFLARAWRVAHDVTSAPDVVWKSGDPALRRVTHRFLADTPGLVEAFKFNVVVARLMELVNATRKTIDSGAGPADRAVREAAEVTTMALNLFAPYTAEDMWARLGYEPSVSLVPWRKPDPTLLIEEAVTAIVQVDGKVRDRVEVSPKISVDELEALARSSEAVLRSVGDREIVTVIVRAPKLVNIATRSRS
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSTX9_HAESL
Sequence: MKTLLVFLLLAILVAVLIGNSQVEACNDNAQCGPLGACIMGYFLPIG
What is the function of this protein?
Leech salivary gland peptide with unknown function.
What are the official names of this protein?
Peptide HSTX-IX.
What is the protein family that this protein belongs to?
Belongs to the annelide toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL36_MYCLB
Sequence: MKVNPSVKPMCDKCRVIRRHRRVMVICVDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: DJLA_ECO57
Sequence: MQYWGKIIGVAVALLMGGGFWGVVLGLLIGHMFDKARSRKMAWFANQRERQALFFATTFEVMGHLTKSKGRVTEADIHIASQLMDRMNLHGASRTAAQNAFRVGKSDNYPLREKMRQFRSVCFGRFDLIRMFLEIQIQAAFADGSLHPNERAVLYVIAEELGISRAQFDQFLRMMQGGAQFGGGYQQQSGGGNWQQAQRGPTLEDACNVLGVKPTDDATTIKRAYRKLMSEHHPDKLVAKGLPPEMMEMAKQKAQEIQQAYELIKQQKGFK
What is the function of this protein?
Regulatory DnaK co-chaperone.  Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway.  The colanic acid capsule may help the bacterium survive conditions outside the host.
What are the official names of this protein?
Co-chaperone protein DjlA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type III membrane protein.
Protein: TYRP1_FELCA
Sequence: MKAHKFLSLGYIVLPLLCSPQTWAQFPRQCATVEALRNGVCCPDLSPLSGPGTDRCGSSSGRGRCEAVTADSRPHSLHYPHDGRDDREAWPTRFFNRTCRCNGNFSGHNCGTCRPGWKGAACDQRVLIVRRNLLDLSAEEKNHLVQALHLAKRTMHPQFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGPGQESFGEVDFSHEGPAFLTWHRYHLLQLERDMQEMLQDPSFSLPYWNFATGKNICDICTDDLMGSRSNFDPTLISLNSVFSQWRVVCESLEDYDTLGTLCNSTEGGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAIRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADVSTFPLENAPIGHNRQYNMVPFWPPVTNIEMFVTAPDNLGYTYEVQWPSRNFSISELVTIGVVAALSLVAVIFAGASCMIRARSNMDEAHQPLLTDQYQHYAEEYEKMHNPNQSMV
What is the function of this protein?
Plays a role in melanin biosynthesis.  Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+).  May regulate or influence the type of melanin synthesized (By similarity).  Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
What are the official names of this protein?
5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, Tyrosinase-related protein 1, TRP, TRP-1, TRP1.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Protein: CLDS_CISCR
Sequence: MAFTFTSAHLFLPVTENHSVHVNYSIPPGNWRLWSTAKGGSNKLDIRRLRCSARRTPEPLAQGSNGGRDGVEAIQRLQTIADDKIDGGANELGIVVWDLIRDGVDAVKSMFDSMGDGDISISAYDTAWVALVKDVNGSGGPQFPSSLQWIVDNQLPDGSWGDSEVFSAYDRLLKTLACVVALKSWNIRPDKCQKGLKFFRDNISKLEKENVEASAQMLSGFEVVFLSLIEVARRLDIQIPLHSPVFEDLIARRNLKFAKIPLDLMHNVPTSLLNSLEGMTGVELDWEKLLKLQSQDGSFITSPSSTAFALMQTNDTKCLGYLKFVVQKFNGGAPGQYPVEIFERIWVVDRLQRLGISRYFQLEIKECCLDYAFKHWTQYGSSWARNTPVYDLDDTCMAFRILRLHGYDVSAEAFRHFEKNGVFFCFGWETTQSVTVNFNLYRATQVAFPGENILKEAKQFSFNFLMKKQAAREFQDKWVILKDFPGELKYALEFPWYASLPRVETRFYVEQYGGDNDVWIGKTLYRMPYINNNVYLELAKLDFNNCQALHRKEWETMQKWFMESKLDEFGVSSKTLLESYFLAAASIFEPERSTERLAWAKTAFLMETIGSYFDDEMNSKDLRKAFVQEFKNIYERRMEAKGTKWNLIIILLTTLNHLTEVCGRDINSYLCHSWEKWMMMWEPEGDRYKGAAELLSNSINLSSGRLFSNDTLSHPNYEKLVTLSNKLCHQLGNSRRGNHNEDSDIKDTKIEIAMQELVQLVHQNSSDDISMDLKQTFFAVVRSFYYAAHCDRGTINSHIVKVLFESVV
What is the function of this protein?
Involved in the biosynthesis of oxygen-containing labdane-type diterpenes that may be implicated in direct and indirect defense mechanisms.  No activity with geranyl diphosphate or farnesyl diphosphate as substrate.
What are the official names of this protein?
Copal-8-ol diphosphate hydratase, chloroplastic, Copal-8-ol diphosphate synthase, CcCLS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATAT_LEIBR
Sequence: MRLSAQLTNTKLADEEVPELASVPDGVSRWTGADLDRLRSAARRGGVGAEQQDLEQKLCRTIDILGARSQKTQGINAVLTSVARLRESNTFRLYLLTQNHRGVGILKMGVKKLFVTHPVTCGLVEVDPLCVLDFYVDESCQRQGYGKQLYAHMLDAEHVSRPELLAIDRPSDKLLGFMKKHYGLTAYTPQVNKFVVFHGFFGHTTVSERGKLLRTTSPTGAAAAATGTKAKNEMPG
What is the function of this protein?
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules.  Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity.  Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer.  Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules.  Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
What are the official names of this protein?
Alpha-tubulin N-acetyltransferase, Alpha-TAT, TAT, Acetyltransferase mec-17 homolog.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase ATAT1 family.
Protein: GRIP2_XENLA
Sequence: MHFFQTILRWKTAKGQKSVTFKKDDGPYSKGNKDPAGNDLALVSRRQSIPEEFRGVTIVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDQLNIGDYIKSVNGINLTKLRHEEIISLLKNVGERVVLEVEYELPPGTPDNSSAIIPKTIEITLCKEGNSFGFVMRGGAHEDWHKSRALVVTYVRPGGPADREGTLKVGDRLLCVDGISLHNITHTDALSILRQCSQEGVFQIEYDVALMDTVTNASGPLLVEIAKTPGSTLGISLSTGTHRNKQVIVIDKVKPASVVDRCGALHPGDHILSIDGTSTEHCTQMEATQLLASIIENVKLEILPAHHSRLPLRPPETVKVQKSDHHHCWDPCVNYCHTPHPGHCKTPTWNPTSNQDYCKSLVAANFSSSSVAGTPGFSSQNSNTLPRTVHPMSPRTTMNRRRQKRKDHKSSLSLASSTVGPGGQIIHTESTEIILRGDPLNGFGIQLQGGIFATETLSSPPLIRFIEPDSPAERCGLLQVGDRLLSINGILTEDGTLEEANQLLRDAALSNKVALEIEFDVAESVVPSSGTFHVKLPKRKGVELGITISSSRKPGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCSMEDAVQILRQCEDLVKLKIRKDEDNSDEQETSGAIIYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHIGDRILAINNISLKGKPLSEAIHLLQMAGETVTLKIKKQTERIFPQRLSDSMNEGSDPEDDLTDSQKTSKLSEIYSTTVPSVDSALESWDGSGIDAGYGSQGTYVPQAVGISLHPHEWRTSRQKSNTPPVEHRKSYPFLDGSFNEQDWEKPTRYPSQPNGLETDHDDSFWRVFGEALEDLETCGQSELLREIEASIMTGSVQDLGLDSSQILLENSSQGGHVLFRRGSHHISSNSPKKENKLSQDARSKKEEVHNAQSLTTELLKVTVQKDMDTDDFGFSVSDGLLEKGVYVNMIRPGGPADRSGLKTYDQILQVNHVRTRDFDCCLTVPLLSDAGDRLDLVISRGLSIKAEEMGVEQIKGPLRMETQTSTKTL
What is the function of this protein?
Plays an important role in primordial germ cell (PGC) maintenance and efficiency of PGC migration.
What are the official names of this protein?
Glutamate receptor-interacting protein 2, xGRIP2, xGRIP2.1.
What is the protein family that this protein belongs to?
Belongs to the GRIP2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_PIPCE
Sequence: MKIRASARKICEKCRLIRRRGRILVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 3HBH_POLNA
Sequence: MSDNPADLPVLVAGGGIGGLAAALALVRRGFSVKVLEQAPEIGEIGAGIQLGPNAFHAFDALGIGEKARGRAVYTDEMVMHDAIDGSLVGRIPTGEAFRQRFGNPYAVIHRVDVHLSLLEGAQETGKVEFLTSTRALRIEQDEGSVTVYDQHGNAHKGIALIGADGVKSVVREQFVGDAARVTGHVVYRAVVDKKDFPESLQWNAASIWVGPNCHLVHYPLRGGEQYNVVVTFHSRQPEQWGVTEGSKEEVQSYFQGICPQARQLIDLPKTWKRWATADREPIGQWSFGRVTLLGDAAHPTTQYMAQGACMAMEDGVTLGEALRVNNNDFPKAFELYQRSRVARTARIVLSSREMGRIYHAQGVERLVRNDLWKGRTPERFYDAMEWLYGWNVGNCLAKD
What is the function of this protein?
Catalyzes the NAD- or NADP-dependent conversion of 3-hydroxybenzoate to gentisate.  The affinity of the enzyme toward NAD is twice as high as for NADP.
What are the official names of this protein?
3-hydroxybenzoate 6-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxybenzoate 6-hydroxylase family.
Protein: RO21_XENLA
Sequence: MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGTLTDCVVMRDPASKRSRGFGFVTFSCMNEVDAAMATRPHTIDGRVVEPKRAVAREESAKPGAHVTVKKLFVGGIKEDTEEHHLREYFEEYGKIDSIEIITDKQSGKKRGFAFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSKQEMQDVQNTRNNRGGNFGFGDSRGGGNFGSGPGGNFRGGSDGYGGGRGYGDNGYNGYGGGQGGGNYGGGPSYGGGRGGGYGGGAGYGNQGGGYGGGYDNYGGGNYGGGGNYNDFGNYNQQSSNYGPMKSGGNFGGNRSMGGGPYGGGNYGPGNASGGNGGGYGGRNRY
What is the function of this protein?
Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein A2 homolog 1, hnRNP A2(A).
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes.
Protein: XERC_LACDA
Sequence: MTLEEQFLSYLKNERSYSPKTVLAYQKDLAAAKKFWQENGGFPGWDQISRRDLEIYLLATGQKLASSTLSRKLSSLKSFYRFLTRRGLVKADPTVAIQLRRGKKKLPEFFYQDEVGQVIRSLNDGKPLTVRNRAIVALFYATGMRLSELTDLKIKQLDLENGMILVHGKGNKDRYVFFDQESKKYLEEYLQAARPSLLKNEPDTGAVFLNKLGRPISSRGIAKAVQQIFQKAGLTAGAHPHELRHSFATAMLNNGADLRSVQELLGHEDLSTTQIYTHVSMQHLTVEYRQHFPRK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_AZOSB
Sequence: MKFFLDLLPVILFFVAYKFAGAAPDDSHALVAQFLGAGISPSQAPILIATAVAIAATLAQVLIVWLRHGKVDKMLWVSLAIITLFGGATLVFHNPTFIKWKPTVFYWTFAGALAVSALLFRRNLVQKMLEAQIRLPAPVWQRLNLAWIGFFTLMGFLNLYVAYGYSEEAWVNFKLFGAMGLMLAFFLGQGFYLSRHLEEDAK
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSRP_RHORT
Sequence: MARAGNSLISHGRVAENRRARHDYSIEETIEAGLILVGTEVKSLRTGRANIADSYAGPKSGELYLYNAYIPDWTQAVKAFAHEPRQPRKLLVHRREARRLISAINKDGMTLVPLYLYFNDRGFAKVQLGLAKGRKAHDKRQAIKEREWNRDKARVLRDKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: AE7_ARATH
Sequence: MVSGLINENPIIYPKKERRLRTDTSITDELTPEPIDQLEIFDHIRDIKDPEHPNTLEDLRVVTEDSVEVDDENSYVRVTFTPTVEHCSMATVIGLCVRVKLLRSLPSRYKIDIRVAPGSHATEDALNKQLNDKERVAAALENPNLVEMVDECLPSEE
What is the function of this protein?
Central member of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway (PubMed:23104832).  Involved in leaf polarity formation (PubMed:21070412).  Promotes leaf adaxial identity (PubMed:21070412).  May play a role in the cell cycle progression and is required for cell proliferation (PubMed:21070412).
What are the official names of this protein?
Protein AE7, AS1/2 enhancer 7, Asymmetric leaves 1/2 enhancer 7.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RLME_KLEP7
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKIFKPGMTVVDLGAAPGGWSQYAVTQIGNSGRIIACDLLPMDPIVGVDFLQGDFRDELVLKALLERVGDSKVQVVMSDMAPNMCGTPAVDIPRAMYLVELALEMSRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_IPOPU
Sequence: MSRYRGPRFKKIRRLGALPGLTNKRPRAESDLRNQSRSGKKSQYCIRLEEKQKLRFHYGLTERQLIQYVRIARKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPAARQLVNHRHILVNGRIVDIPSYRCKPRDIITSKDNQKSRALIQNSLESSPHEELPNHLALDPSPYYKGLVNQIIDTKWVGLKINEFLVIEYYSRQTN
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IL1A_RAT
Sequence: MAKVPDLFEDLKNCYSENEEYSSAIDHLSLNQKSFYDASYGSLHENCTDKFVSLRTSETSKMSTFTFKESRVVVSATSNKGKILKKRRLSFNQPFTEDDLEAIAHDLEETIQPRSAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASLNDLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETPKLITGSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSMIDFQIS
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.