PharMolix/UniProtQA huggingface dataset:
Protein: MSCL_XANC5
Sequence: MGMVSEFKQFAMRGNVIDLAVGVVIGAAFGKIVTALVEKIIMPPIGWAIGNVDFSRLAWVLKPAGVDATGKEIPAVAIGYGDFINTVVQFLIIAFAIFLVVKLINRVTHRKPDAPKGPSEEVLLLREIRDALKNDTLKPPGAL
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SDR5_ARATH
Sequence: MSGQRLDGKIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLDKASFYRCDITDETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAFIKHAARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVNGVAPYGVATGLTSYNEETVKMVEDYCSATAILKGVVLKARHVADAALFLASDDSVYISGQNLGVDGGYSVVKLTSN
What are the official names of this protein?
Short-chain dehydrogenase reductase 5, AtSDR5.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: XPT_CLOBA
Sequence: MENLHNRILEEGQALSSDVLKVDSFLNHQVDADLMYEMGTYFKNYFKDHNITKIFTIESSGIAPTVMTAMQMNLPMVILKKQGSKILKGDVYQTTVHSFTKGTDYELTLQKKYINEDDNILIIDDFLANGEAALGAARLVEGAGAKVAGIGIVIEKSFQPGPKLLEEKGYDVYSLARIEKLEKGIIKIKK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_CUPMC
Sequence: MSQLTHFDNAGQAHMVDVGNKANTHRVAVATGTITMLPATFALVRDGSAKKGDVLGIARVAAIMATKRTADLIPLCHPIGLTKVAVDFALDEPSSTIACIVRTETHGQTGVEMEALTGVQVALLTIYDMCKAVDRGMVMGNVKLLEKHGGKSGDWVAGA
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: MENG_BACAN
Sequence: MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESASTFPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: Y1855_MYCBO
Sequence: MGSDTAWSPARMIGIAALAVGIVLGLVFHPGVPEVIQPYLPIAVVAALDAVFGGLRAYLERIFDPKVFVVSFVFNVLVAALIVYVGDQLGVGTQLSTAIIVVLGIRIFGNTAALRRRLFGA
What are the official names of this protein?
Uncharacterized protein Mb1855.
What is the protein family that this protein belongs to?
Belongs to the sbp family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TUSB_BUCAP
Sequence: MLHTLMKSPFETNISFFSGMLKKTDDFLALQDGVLIALIDNIFLKKITFSSENLYVIKEDVYARGIHKNISSSFILISYIDFVNLTLKNKKQIIW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUS1_CANGA
Sequence: MTISSNENSASLRAQIQQCLVESGNYEAISNELTERLLKDGWLDEVKKLAREEISQEDSPNFSKALSQIEPQALDLVQQSTKDAIMRKITAFLEEIVETE
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels.  The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.  May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
What are the official names of this protein?
Transcription and mRNA export factor SUS1.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm, P-body.
Protein: SO1C1_MACFA
Sequence: MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLIMGVGTLLIAMPQFFMEQYKYEIYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIRDDHTDYQTPQGENVKIMEMARDFLPSLKYLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIAMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNPRCKCSETKWEPMCGENGITYVSACPAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLSIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSIFLSIAVLFILKKNYVSKHRNFITKRERTMVSTRFQKENCTTSDHLLQPKYWPGKETQL
What is the function of this protein?
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane.  Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases.  Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases.  Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency.  Transports T4 and E1S in a pH-insensitive manner.  Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain.
What are the official names of this protein?
Solute carrier organic anion transporter family member 1C1, Solute carrier family 21 member 14, Thyroxine transporter.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).
Protein: RL24_WOLWR
Sequence: MSAKIKSGDDVIVLTGKDKGKIGKVIKVIARDAKKKVIVSGVNVHKRHTKPKAGSSGGILNKELAIDISNVATLDPKYKTPTRVGFKVIDGRKVRFAKVSGEVID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: UBXN7_PONAB
Sequence: MAAHGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEPSTSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETAKECGQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKLVEWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPVRTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRRKLSHLDYDITLQEAGLCPQETVFVQERN
What is the function of this protein?
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity).
What are the official names of this protein?
UBX domain-containing protein 7.
Protein: MTH12_DROME
Sequence: MFLWLKCFCTLIIVTIAKNSSAKIPHCKYDETINISHFKRLNDAYIYEHFEIPANLTGEFDYKELMDGSKVPTEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER
What are the official names of this protein?
Probable G-protein coupled receptor Mth-like 12, Protein methuselah-like 12.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AKR1_KLULA
Sequence: MTAEEVDKESDPAIEDVKSDYDAIELGNENENENEVVSLDSMKAVISRASSELKHENDQGEERDLGSVEKDPILERYHAACKQGDMKTLREMVESKVIDLSNDYDPKERVSGLHWACINNRLSAVKYLAGAGAEVNFKGGELDATPLHWASKSGLVYIVDELLKAGADPNITDSQGYNLLHTSVFSSNIMLVIYVLFFVVDGKEDVDQPDPHQRTALQWATYQADALTVENLLKFNADVKNADDAGFTALHWGTVKGSIPVMDLLIKHGSDFFQTTNDGKNCFTIGKELYSIGSLEASLYKNGFDKNGFPLPQYFSASTGKMLTFFLPWVLIPLVFYIFSKITFFIALLINTIVLVISGLVLSRLVVPSYLLSKRHPILNSPLLAGILSGTIAIAFFIWFTKISILTFTEKPVGNIIMLGFFIGLITLFIGLMKSDPGYIPGTVDHDKVRETIKELLSLGKFDAKHFCVHTWIRIPLRSKYDRDSACLISAFDHFCPWVYNQIGLLNHKLFYMFVVLLEISVWWFLPLMMEYFDELEDYLENRKGKHFGDCHFLGDEDLCFGLHHDTFNFLLLCWVIFQAFWVLCLIAVQTVQMLKGVTDYEFVQINKKLKSNGTTTEDIFSSTPPELMSEELIAELDAPALDPRQVPQRTCFTVCCTLLGLDKLVTMIKSVLRLKSDEPSSRSSHLSALARIPTDYGWKQNLKDFWLLPDTSSPLWRRILLPPKDSHALLNGMEVDYYTLYTLPNATEELV
What is the function of this protein?
Palmitoyltransferase specific for casein kinase 1.
What are the official names of this protein?
Palmitoyltransferase AKR1, Ankyrin repeat-containing protein AKR1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: OTC_ASPTE
Sequence: MIPTARCGALRQKIPVQAVRQYSSSTTLKTSPFAPRHLLSIADLTPTEFTTLVRNASSHKHSIKSGSIPTNLQGSLAGKTVAMMFSKRSTRTRISTEGATVQLGGHPMFLGKDDIQLGVNESLYDTAVVVSSMVSAIVARVGKHAEVADLAKHSTVPVINALCDSFHPLQAIADFQTIYETFTPKAHHLSSLGLEGLKIAWVGDANNVLFDMAISAAKMGVDLAVATPKGYEIPASMRELIQEAGKGVANPGKLIQTNVPEEAVKKADILVTDTWVSMGQEEESLKRMKAFEGFQITSELAKRGGANENWKFMHCLPRHPEEVSDEVFYSNRSLVFPEAENRLWAAISALEGFVVNKGKIA
What are the official names of this protein?
Ornithine carbamoyltransferase, mitochondrial, Ornithine transcarbamylase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: QPTR_ECOLI
Sequence: MNVFSQTQRYKALFWLSLFHLLVITSSNYLVQLPVSILGFHTTWGAFSFPFIFLATDLTVRIFGAPLARRIIFAVMIPALLISYVISSLFYMGSWQGFGALAHFNLFVARIATASFMAYALGQILDVHVFNRLRQSRRWWLAPTASTLFGNVSDTLAFFFIAFWRSPDAFMAEHWMEIALVDYCFKVLISIVFFLPMYGVLLNMLLKRLADKSEINALQAS
What is the function of this protein?
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.  Transports 7-cyano-7-deazaguanine (preQ(0)) and 7-aminomethyl-7-deazaguanine (preQ(1)), with a preference for preQ(0).
What are the official names of this protein?
Queuosine precursor transporter, Q precursor transporter.
What is the protein family that this protein belongs to?
Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIG3_CAEEL
Sequence: MGRLLAKMLFPLAMCLFVSAVSASDSPSSNEANPIVISSEAMDYDTNTITVREGKKLMVSCVFESDEQIHKSDLLWKQANGNNIDGESNPSLFSVILNEKGSKHRKTSLHFSSVHTRDTGLYTCTGRTAGGENFEKTIKLVVLPAIEWNDKDTVKGALLGEPITIDCGVKGPSGKEPMIQMTNGNGEPLDEEIWTIAGNEATIDSLKKEHAELTVSCITIEMHQETSKEEFPVVDRKDVNIEVYTLPEFETEESVQYTVIDNHVRDAIIYCNVTHSFPPVRHYTFYHGDEEIKMSDKFNIFVNVGVSQGAHLKIHNVNENDLGTYKCEANNIKAKSYHTIHLREANAPAEPKVTLIEDKRHSIIWKVESIDRDPDLPMTAVEIRHLRAGTAEASGVSDEDISDAYWKSHSIFMQRNIKDDGIYEINGLRHGHEYVWRFRQINEAGFGDSVVLRAKTLDDHDLEMMDSASDSKFPLALATLFFVCLFI
What is the function of this protein?
Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling.
What are the official names of this protein?
Neuronal immunoglobulin domain-containing protein rig-3.
What are the subcellular locations of this protein?
Cell projection, axon. Synapse. Cell membrane; Lipid-anchor, GPI-anchor. Note=Membrane association is important for synaptic function.
Protein: RL13_SYNS3
Sequence: MNKTSVPSIDSIDRQWYLVDAENQTLGRLATEVASVLRGKNKASFTPHLDTGDFVIVVNADKIRVSGKKPQQKLYRRHSGRPGGMKVETFEHLQERLPERIVEKAIKGMLPHNALGRQLFRKLKVYKGTEHPHAAQQPKTLQLDPAASAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y145_CAMJ8
Sequence: MGVKAYLDGILGEDKACKFLKKQGFEILKRNFHSKFGEIDIIAKKDEILHFIEVKFTQNDYEVSERLDRKKLEKILKTIEFYHLKNGISSDFQIDLICIKNDVIQFCENISF
What are the official names of this protein?
UPF0102 protein C8J_0145.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: CLD1_HUMAN
Sequence: MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
What is the function of this protein?
(Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151).  Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010).  Acts as a receptor for dengue virus (PubMed:24074594).
What are the official names of this protein?
Claudin-1, Senescence-associated epithelial membrane protein.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: XERS_STRP2
Sequence: MKREILLERIDKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKEYDRFFSWVLESGISNADKISDIPLSVLENMSKKDMESFILYLRERPLLNANTTKQGVSQTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQKLFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAVNLDLRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLYRGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHASTQVTDLYTHIVNDEQKNALDSL
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
What are the official names of this protein?
Tyrosine recombinase XerS.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_PSYA2
Sequence: MNTADITAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILSANKIDMDNGQKNDLDAALLDRLELNDARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAFESNQAIAKCILEGLKKVGMSEYSVQVLETTDRAAVGELITMTDYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFIDSDADPEIAIKVSVNAKTHRYGTCNTMETLLVDEAIANELLPKIAEAIVKADDAMQLRLDDKAQAILNDNTTLKGHLSAATAEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVIITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWIVYGHGETRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHE4_SYNY3
Sequence: MAGSLFADASKRLEKALKYVAISDDAGERLKYPKTSLSVSIPVRMDDGSLKIFPGYRVRYDDTRGPGKGGVRYHPNVTMDEVQSLAFWMTFKCALLNLPFGGAKGGITLNPKELSRAELERLSRGYIEAIADFIGPDIDILAPDVYTNEMMMGWMMDQYSIIRRKISPAVVTGKPVTMGGSQGRNTATGTGAFYIMQGMLPKFDQYPENTTVAVQGFGNAGMVVAECLYQDGYKVVAISDSQGGIYNEQGIDIPAVIDYKQRHRTLAGMYCDQAICDLGENQQISNAELLALDVDVLIPAALENQITRDNADQVRARYIFEVANGPTTTAADDILASKGIYVFPDILVNAGGVTVSYFEWVQNRSGLYWSAKEVNDRLKEKMVEEAEHVWNITQELDVNVRTAAYIHALNRLSEAMDAKGTRDYYQDS
What is the function of this protein?
Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: PUR5_NOVAD
Sequence: MSDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGYNDPLLVAGNDGVGTKVKLAIDHDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLDNGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYDLAGFCVGAVERGEQLTGDRVAEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSLLPFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEEMARTFNCGIGMILAVNPAQADALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARSAWEATHIG
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_RHIME
Sequence: MNTQTAPSPQFYLTAPAACPYLPNQMERKVFTHMVGERAPELNDLLTQGGFRRSQNIAYRPACETCRACISVRILTNEFAPTRSMRRVLAANGEIVSAEYPAEPSSEQYNLFRRYLDCRHQKGGMSDMSVLDYAMMVEDTHVHTKIIEYRLRVEGDGINDKARGPLIATALTDRMSDGLSMVYSFFDPALSERSLGTYMILDHIRRAKERGLPHVYLGYWVKGSRKMGYKTKFLPQEHLMARGWERYSGEHDSTKPATD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_THIDA
Sequence: MRFDAVTLFAEMFDAVLDYGITRRALDRGLYRFKSWNPRAFTDDPHRTVDDRPYGGGPGMLMLAEPLDRALNAVQQELASENLAPWVVHFSPRGRPLTQQRVMELKDMPALVLLCGRYEGIDERLLQRRVDEEVSLGDFVLSGGELPALALMDAIVRQLPGALNDAESAAQDSFSAGLLDCPHYTRPEVWQGMAVPQVLKSGNHAAIAKWRHEQSLRLTGALRPDLLERAQHDERN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_FRATO
Sequence: MVILGIDPGSRITGFGVIKVQDNKIYYVASGCIQITEITTPKRLKQIADGITQIINIYAPTEAAIEQIFMFQNPMGAIKLGQARGVAMCTLAINNLEVSEYSAKQIKQAVVGTGGAAKSQVQHMVQSLLGLSKKPPEDAADALAIAICHYHSSKSLAKISGASRVSQKRIK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: PRIM_HCMVT
Sequence: MTLVLFATEYDSAHIVANVLSQTPTDHCVFPLLVKHQVSRRVYFCLQTQKCSDSRRVAPVFAVNNETLQLSRYLAARQPIPLSALIASLDEAETQPLYRHLFRTPVLSPEHGGEVREFKHLVYFHHAAVLRHLNQVFLCPTSPSWFISVFGHTEGQVLLTMAYYLFEGQYSTISTVEEYVRSFCTRDLGTIIPTHASMGEFARLLLGSPFRQRVSAFVAYAVARNRRDYTELEQVDTQINAFRERARLPDTVCVHYVYLAYRTALARARLLEYRRVVAYDADAAPEAQCTREPGFLGRRLSTELLDVMQKYFSLDNFLHDYVETHLLRLDESPHSATSPHGLGLAGYGGRIDGTHLAGFFGTSTQLARQLERINTLSESVFSPLERSLSGLLRLCASLRTAQTYTTGTLTRYSQRRYLLPEPALAPLLERPLPVYRVHLPNDQHVFCAVASETWHRSLFPRDLLRHVPDSRFSDEALTETVWLHDDDVASTSPETQFYYTRHEVFNERLPVFNFVADFDLRLRDGVSGLARHTVFELCRGLRRVWMTVWASLFGYTHPDRHPVYFFKSACPPNSVPVDAAGAPFDDDDYLDYRDERDTEEDEDGKENKNNVPDNGVFQKTTSSVDTSPPYCRCKGKLGLRIITPFPACTVAVHPSVLRAVAQVLNHAVCLDAELHTLLDPISHPESSLDTGIYHHGRSVRLPYMYKMDQDDGYFMHRRLLPLFIVPDAYREHPLGFVRAQLDLRNLLHHHPPHDLPALPLSPPPRVILSVRDKICPSTEANFIETRSLNVTRYRRRGLTEVLAYHLYGGDGATAAAISDTDLQRLVVTRVWPPLLEHLTQHYEPHVSEQFTAPHVLLFQPHGACCVAVKRRDGARTRDFRCLNYTHRNPQETVQVFIDLRTEHSYALWASLWSRCFTKKCHSNAKNVHISIKIRPPDAPMPPATAV
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.