PharMolix/UniProtQA huggingface dataset:
Protein: SFXN1_CAEEL
Sequence: MNNLVVNQTVLPDISKPKWDQGTYAGRAKHFFSSTNPLTLFSSRIQQEKCKEIVTNYKTGVISPTLTVDELWKAKTLYDSTYHPDTGEKMFFLGRMSAQMPGNMVTTGMLLGLYRTLPGVVFSHWFNQSFNAVVNYTNRSGNSKATNERLFVSYCCATSGAMTVALGLNKMVKNSHGLAARLVPFAAIALANAINIPMMRSNEASEGMELKDENDQLVGKSQKMAALSIAQVTLSRIAMAMPYMVMTPIIMNRITRTAYYRTRPWMQKYSEIPIQTLIAGIGLYFTTPLCCALFPQKSSVEVEKLESSVQKEIMSRPNPPKIVYYNKGL
What is the function of this protein?
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria.  Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.  May also transport other amino acids including alanine and cysteine.
What are the official names of this protein?
Sideroflexin-1.1.
What is the protein family that this protein belongs to?
Belongs to the sideroflexin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DEOB_STAA3
Sequence: MTRPFNRVHLIVMDSVGIGEAPDAADFKDEGSHTLRHTLEGFDQTLPNLEKLGLGNIDKLPVVNAVEQPEAYYTKLSEASVGKDTMTGHWEIMGLNIMQPFKVYPNGFPEELIQQIEEMTGRKVVANKPASGTQIIDEWGEHQMKTGDLIVYTSADPVLQIAAHEDIIPLEELYDICEKVRELTKDPKYLIGRIIARPYVGEPGNFTRTSNRHDYALKPFGKTVLDHLKDGGYDVIAIGKINDIYDGEGVTEAVRTKSNMDGMDQLMKIVKKDFTGISFLNLVDFDALYGHRRDKPGYAQAIKDFDDRLPELFSNLKEDDLVIITADHGNDPTAPGTDHTREYIPVIMYSPKFKGGHALESDTTFSSIGATIADNFNVTLPEFGKSYLKELK
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_BDEBA
Sequence: MSEENNSQNSNPPNPENGEIASEIQKLQEQAEKFKNDYLYLRAEFENYKRNAIKERSELMKYGGERLVRDLLEVVDNFDRALSVNVSAENFNTFKQGVDMTAQELKSLLQRHNVIEIPAHGAPFDPSVHEALSSEATDQMAPGHIVRVFKKPYKLHDKVIRPGQVVVAKKPE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_PASMU
Sequence: MLKRSMNIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKELFHADYVNVQPHSGSQANAAVYGALLQPHDTILGMSLAHGGHLTHGASVSFSGKIYNAVQYGITAEGLIDYEDVRQKALECKPKMIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGVYPSPLPHAHVVTTTTHKTLGGPRGGLILSAAKDEDLYKKLQSSVFPANQGGPLVHVIAAKAVCFKEALEPEYKVYQQQVVKNAKAMVDVFKQRGYNVVSNGTENHLFLVDLVSHGLTGKAADAALGSANITVNKNAVPNDPQKPFVTSGIRVGTPSITRRGFKEAESAELAGWMCDVLDAMGKDNEAQVIAQTKEKVLAICKRLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_THESQ
Sequence: MDKIFESLYKAGCDVRMFEKLSCHTSIKIGGRVKYLVLPNDVFSLERAITVLKDFPFQIMGLGTNLLVQDEDLDIAVLKTERLNQIEIKGEKVLVESGTPLKRLCLFLMEAELGGLEFAYGIPGSVGGAIFMNAGAYGGEIGEFIEAVEVLKDGRKIWLSKNEIFFGYRDSTFKREKLIITRAMMSFKKEKKETIKAKMEDYMRRRLEKQPLDLPSAGSVFKRPREDFYVGKAIESLGLKGYRIGGAQISEKHAGFIVNTGSATFDDVMKLIEFVRKKVKEKYGVELETEVEIWWNGRQW
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_STRPM
Sequence: MSVVNNRVALTNLVSMEALTTEEVLGLINRGSEYKAGKVVISDHQKDLVANLFFENSTRTHKSFEVAEKKLGLTVLDFNADASAVNKGESLYDTVLTMSALGTDICVIRHPEDDYYKELVESPTITASIVNGGDGSGQHPSQCLLDLLTIYEEFGRFEGLKIAIAGDLTHSRVAKSNMQILKRLGAELYFYGPEEWYSEAFNAYGTYIAIDQIIKELDVLMLLRVQHERHDGHQSFSKEGYHQAFGLTQERYQQLKDSAIIMHPAPVNRDVEIADSLVEAPKARIVSQMANGVFVRMAIIEAILNGRNKNS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: LFHA_ECO44
Sequence: MAKTTKSFLALLRGGNLGVPLVILCILAMVILPLPPALLDILFTFNIVLAVMVLLVAVSAKRPLEFSLFPTILLITTLMRLTLNVASTRVVLLHGHLGAGAAGKVIESFGQVVIGGNFVVGFVVFIILMIINFIVVTKGAERISEVSARFTLDAMPGKQMAIDADLNAGLINQAQAQTRRKDVASEADFYGAMDGASKFVRGDAIAGMMILAINLIGGVCIGIFKYNLSADAAFQQYVLMTIGDGLVAQIPSLLLSTAAAIIVTRVSDNGDIAHDVRHQLLASPSVLYTATGIMFVLAVVPGMPHLPFLLFSALLGFTGWRMSKRPQAAEAEEKSLETLTRTITETSEQQVSWETIPLIEPISLSLGYKLVALVDKAQGNPLTQRIRGVRQVISDGNGVLLPEIRIRENFRLKPSQYAIFINGIKADEADIPADKLMALPSSETYGEIDGVLGNDPAYGMPVTWIQPAQKAKALNMGYQVIDSASVIATHVNKIVRSYIPDLFNYDDITQLHNRLSSMAPRLAEDLSAALNYSQLLKVYRALLTEGVSLRDIVTIATVLVASSTLTKDHILLAADVRLALRRSITHPFVRKQELTVYTLNNELENLLTNVVNQAQQAGKVMLDSVPVDPNMLNQFQSTMPQVKEQMKAAGKAPVLLVPPQLRPLLARYARLFAPGLHVLSYNEVPDELELKIMGALS
What is the function of this protein?
Part of the flagellar gene cluster Flag-2.  However, the Flag-2 flagellar system could be inactive in strain 042 due to a frameshift in lfgC.
What are the official names of this protein?
Putative flagellar export/assembly protein LfhA.
What is the protein family that this protein belongs to?
Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTR19_ARATH
Sequence: MEVEEEVSRWEGYADWRNRAAVKGRHGGMLAASFVLVVEILENLAYLANASNLVLYLREYMHMSPSKSANDVTNFMGTAFLLALLGGFLSDAFFSTFQIFLISASIEFLGLIILTIQARTPSLMPPSCDSPTCEEVSGSKAAMLFVGLYLVALGVGGIKGSLASHGAEQFDESTPKGRKQRSTFFNYFVFCLACGALVAVTFVVWLEDNKGWEWGFGVSTIAIFVSILIFLSGSRFYRNKIPCGSPLTTILKVLLAASVKCCSSGSSSNAVASMSVSPSNHCVSKGKKEVESQGELEKPRQEEALPPRAQLTNSLKVLNGAADEKPVHRLLECTVQQVEDVKIVLKMLPIFACTIMLNCCLAQLSTFSVQQAASMNTKIGSLKIPPASLPIFPVVFIMILAPIYDHLIIPFARKATKTETGVTHLQRIGVGLVLSILAMAVAALVEIKRKGVAKDSGLLDSKETLPVTFLWIALQYLFLGSADLFTLAGLLEYFFTEAPSSMRSLATSLSWASLAMGYYLSSVIVSIVNSITGSSGNTPWLRGKSINRYKLDYFYWLMCVLSAANFLHYLFWAMRYKYRSTGSRS
What is the function of this protein?
Low-affinity proton-dependent nitrate transporter.  Involved in constitutive nitrate uptake.  Not involved in histidine or dipeptides transport.  Involved in (+)-abscisic acid (ABA) transport, but not in gibberellin, indole-3-acetic acid or jasmonic acid import.  Mediates cellular ABA uptake.  Nitrate does not compete with abscisic acid as a substrate of NPF4. 6 (PubMed:24084651).
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 4.6, AtNPF4.6, Nitrate transporter 1.2, Nitrate transporter NTL1, Protein ABA-IMPORTING TRANSPORTER 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU4M_POROP
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQILPTTKTDMFLPFIVLALWGAILANLTCLQQTDLKSLIAYSSVSHMGLVAAAIIIQTPWGLSGAMALMIAHGFTSSALFCLANTTYERTHTRILILTRGFHNILPMTSTWWLLANLMNIATPPSLNFTSELLIMSTLFNWCPTTIILLGLSMLITASYSLHMFLSTQMGSTLLNSQTEPMHSREHLLMTLHLIPLMMISMKPELVI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: AL7A1_CAEEL
Sequence: MNRLLSSGMSAATLQTRMASQLLINDSKYGFLKELGLTENNAGVFHGKWAASGQVVQSFAPANNSPIANVQNGNVQDYEIAISEAKKAYNDWCEVPAPRRGEIVRQIGDKLRTQLQNLGKLVSLEMGKISAEGVGEVQEYVDICDYATGLSRSLEGKIFPSERPGHALLEQWNPLGVVGVISAFNFPCAVYGWNNALALVTGNSVVWKPAPSTPLTAIAVTKLVEEVLVANNVNPALCSLVCGEGDVGQALVKDKRVNLVSFTGSSEIGKIVGQQVQARFGKLLLELGGNNAIIVNEDADLNMVVPATVFAAVGTAGQRCTTTRRLIVHDKVYDQVLERLKKAYAQFESRIGCPLDSNTIIGPLHNQQAVGKYKASVAEAVASGGKIEYGGKVLERDGNFVLPTIVTGLKHDSPVVLRETFAPILYVLKFSTLEEAIAINNEVDQGLSSSLFTTNIQNVFKWMGPKGSDCGIVNVNIPTSGAEIGGAFGGEKETGGGRESGSDSWRQYMRRSTCTINYSKELPLAQGIKFE
What are the official names of this protein?
Putative aldehyde dehydrogenase family 7 member A1 homolog, ALH-9.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: HTPG_NOCFA
Sequence: MTEHVEQLEFQAETHQLLELMIHSVYSNKDTFLRELISNASDALDKLRLESFKDKDLHVDTADLHIELEVDKDNRILTVRDNGIGMSRAEVVDLIGTLAKSGTAELRRKLSEAKSEAAAEELIGQFGIGFYSTFMVADKVTLTTRKAGETGGTRWESSAGSSTYTIEDLAEAPQGTAVSLHLKPADEEDHLYDYTQEWKLREIVKKYSDFIAWPIRMQVERTVTEGEGEDKQEKTIVEEQTLNSRKALWTRPRGEVSDEEYKEFYKHVSHAWDEPLEIIPLKAEGTFEYQALLFLPSQAPFDLFTREHKRGVQLYVKRVFIMDNCEELMPEYLRFVKGVVDAQDLSLNVSREILQQDRQIQMIRKRLVKKVLATVKDLQQAEDQSKYQTFWREFGRVLKEGLLSDFDNRETILQVSSFASTHSDSELTTLAQYVERMPEGQDAIYYMTGESRQQVESSPHMEAFKAKGREVLILTDPVDEMWVGSVPEFDGKRFQSIAKGEVDLESEEEKKASEALREQQDKEFADLLSWLGKTLEENIKEVRLTNRLTTSPACLVGDVFDFTPMLERMYRASGQPVPVSKRILELNPTHPLVTGLRDAYDQRKQDADEGKVPELTETAELLYGTAVLAEGGELKDPARFAHILTDRLTRTL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG001_VACCW
Sequence: MHVPASLQQSSSSSSSCTEEENKHHMGIDVIIKVTKQDQTPTNDKICQSVTEITESESDPDPEVESEDDSTSVEDVDPPTTYYSIIGGGLRMNFGFTKCPQIKSISESADGNTVNARLSSVSPGQGKDSPAITHEEALAMIKDCEVSIDIRCSEEEKDSDIKTHPVLGSNISHKKVSYEDIIGSTIVDTKCVKNLEFSVRIGDMCKESSELEVKDGFKYVDGSASEGATDDTSLIDSTKLKACV
What is the function of this protein?
The protein is truncated in this vaccinal strain and presumably inactive, because the lack of signal peptide prevents the protein of being secreted.  In the wild-type viruses inhibits host immune defense by binding to host chemokines.  Binds host CC chemokines (beta chemokines) such as RANTES with high affinity, but not CXC or C chemokines (alpha and gamma chemokines).
What are the official names of this protein?
Inactive chemokine-binding protein, vCKBP.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG001 family.
Protein: TECTB_HUMAN
Sequence: MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGFSSLYSFSDVLHHLIMMLGICAVL
What is the function of this protein?
One of the major non-collagenous components of the tectorial membrane (By similarity).  The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells.  Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
What are the official names of this protein?
Beta-tectorin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=Found in the non- collagenous matrix of the tectorial membrane.
Protein: RL23_FRATW
Sequence: MSSQEKLLKTVIRPHVSDKTYGLSDANSTIVFEVARFANKQDVKNAVEKLFEVKVESVNILNVKGKARRFGRVEGRTKAWKKAYVKLAEGHDINFVGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: BTAF1_ARATH
Sequence: MAQQQSSRLNRLLTLLDTGSTQATRLTAAKQIGDIAKSHPQDLSSLLRKVLHHLRSKKWDTRVAAAHAIGAIVLNVKHPSLSELLNSLATKLGEAGISDNVDEVVAFRNLQSKILANAPFRSFEMNKVLEFGALLASGGQEYDILNDNSKNPRDRVARQKKNLRRRLGLDMCEQFMDVNEMIRDEDLIEQKSNVPANGVGNRLYANCSPHHIQQFVSRMVPRVNSRRPSARELNLLKRKAKISSKDQAKGSCEVADVEMSSSHVASTSKRILSDSLDSSKADIGNEDDIEPDGDGKWPFHSFVEQLILDMFDPAWEIRHGSVMALREILMLHGGSAGVSTEEFSSDNGFELKDVLNKVTREREIDLNMQVSENELEPLRKRPKIEDPSKSFIDNTVLEVIGGDYDINVKDEDAEFLLPPVKVNGQTDCSSTKLEPQSSMDDSTSHSEINHVAEVNNHFEDKSFIEEPVIPKQQEENLEVLDLVKQARHSWIKNFEFLQDCTIRFLCVLSLDRFGDYISDQVVAPVREACAQALGATFKYMNPSLIYETLNILLQMQRRPEWEIRHGSLLGIKYLVAVRQEMLQDLLGYILPACKAGLEDSDDDVRAVAADALIPAAAAIVSLRGQTLLSIVMLLWDILLELDDLSPSTSSIMNLLAEIYSQDDMTLVMHEELSLGEEQNIELNEMGHIESIGERRDVKESPYALSGLAPRLWPFTRHDITSVRFSAIRTLERLLEAGCRKNISGQSKSSFWPSSILGDTLRIVFQNLLLESTEEILECSERVWRLLVQCPVDDLEDTAKFYMASWIELAATPYGSTLDATKMFWPVAPPRKSHFKAAAKMKAVKLENEASSILGFDYARSSASLEKQEDASARSTKIIVGSDMEMSVTRTRVVTASALGIFASRLREGSMQFVVDPLSSTLTSMSGVQRQVGSIVLISWFRETKCKAPSDGSGSLPGFPSPLKKWLLDLLACADPAFPTKDIFLPYAELSRTYTKMRNEASQLLHTVETCHCFDKLLSTNKLNVESVTADETIDFASTLDLWNKESAGNESLEKQVFEDVESSRQQLLSTAGYLKCVQSNLHITVTSLVAAAVVWMSEFPARLNPIILPLMASIKREQEQILQQIAAEALAELIAYCVDRKPSPNDKLIKNICSLTCMDPSETPQASIISSMDIVDDMDFLSSRSNTGKQKAKVVLASGEDRSKVEGFITRRGSELALKHLSLKFGGSLFDKLPKLWECLTEVLVPEIPSDQQKIDLKIESISDPQVLINNIQVVRSIAPVMEETLKPRLLSLLPCIFKCVRHSHVAVRLAASRCVMTMAKSMTTDVMAAVVESAIPMLGDLTCISGRQGAGMLIGLLVQGLGVELVPYSPLLVVPLLRCMSDVDSSVRQSVTRSFAALVPMLPLARGVPPPVGLSKDLSSNAEDAKFLEQLLDNSHIDDYKLCTELKVQLRRYQQEGINWLGFLKRFKLHGILCDDMGLGKTLQASAIVASDAAERRGSTDELDVFPSIIVCPSTLVGHWAFEIEKYIDLSLLSVLQYVGSAQDRVSLREQFNNHNVIITSYDVVRKDVDYLTQFSWNYCILDEGHIIKNAKSKITAAVKQLKAQHRLILSGTPIQNNIMELWSLFDFLMPGFLGTERQFQASYGKPLLAARDPKCSAKDAEAGVLAMEALHKQVMPFLLRRTKEEVLSDLPEKIIQDRYCDLSPVQLKLYEQFSGSSAKQEISSIIKVDGSADSGNADVAPTKASTHVFQALQYLLKLCSHPLLVLGDKVTEPVASDLAAMINGCSDIITELHKVQHSPKLVALQEILEECGIGSDASSSDGTLSVGQHRVLIFAQHKALLDIIEKDLFQAHMKSVTYMRLDGSVVPEKRFEIVKAFNSDPTIDVLLLTTHVGGLGLNLTSADTLVFMEHDWNPMRDHQAMDRAHRLGQKRVVNVHRLIMRGTLEEKVMSLQKFKVSVANTVINAENASMKTMNTDQLLDLFASAETSKKGGGSSKKGSEDNDQIAGTGKGMKAILGNLEELWDQSQYTEEYNLSQFLTKLNG
What is the function of this protein?
Involved in meristem development.  Acts as positive regulator of the CUC-STM pathway in shoot apical meristem (SAM) neo-formation.
What are the official names of this protein?
TATA-binding protein-associated factor BTAF1, AtBTAF1, Protein BTAF1 homolog, Protein ROOT GROWTH DEFECTIVE 3.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAA_EHRCR
Sequence: MNNILIITGPTASGKSKISMKIAQDNNGIIVNCDSKQIYREIPIITDQPNLNDTSVEHKLYGYVSVTQQYSVGLWIEDLKDEISSIIQQKKFPVITGGSGMYINSLIYGLSQIPKIEDSVRNETRRLFKTLGKKEFYALLIDKDPIAKCLHKNNSHQLLRAYEVIEQTGISIFVWKENAPREPIFKNFKLCILMPPRSEIYKKINERFINMINTSVIEEIENLLSLNIPAHFPAMKAHGVPEIIQYLQNKISIDQAIEIAQKNTRNYAKRQYTWFKHQFRNALFYESQDQLLESIKNSYVYYN
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FABH_NITEC
Sequence: MAMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEASRNAIEAAGIQASDIDLVIVATTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYALATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFGDGAGAVVLTRDQKPGILSSHLHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSDIDWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQHVVLEGVGGGFTWGSVLVRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STK4_AOTNA
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSHHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSIPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: MASZ1_PSESM
Sequence: MTEYVQVGDLQVARVLFDFVQNEATPGTGVDAGAFWAGADQLIHDLAPKNKALLAQRDELQAQIDAWHQSRAGQAHDASAYKAFLQEIGYLLPEAADFQITTQNVDEEIATMAGPQLVVPVMNARFALNASNARWGSLYDALYGTDAISEEGGAEKGKGYNKVRGDKVIAFARAFLDQAAPLAAGSHVDSTAYKLIDGRLVISLKGGSNTGLRDDAQLVGFQGDASAPFAVLFKHNGLHFELQIDAASPVGQTDPAGVKDIVMEAALTTIMDCEDSIAAVDADDKVVVYRNWLGLMKGDLVESVSKGGETFTRTMNPDRVYTTPQGGEVTLHGRSLLFIRNVGHLMTIDAILDKHGNEVPEGILDGLLTSLAAIHNLNGNNTRSNSRSGSMYIVKPKMHGPQEAAFTNELFGRIEQVLGLPRNTLKVGIMDEERRTTVNLKACIQAASERVVFINTGFLDRTGDEIHTSMEAGPVVRKAQMKAEKWISAYENSNVDIGLKCGLQGRAQIGKGMWAMPDLMAAMLEQKIAHPLAGANTAWVPSPTAAALHALHYHKVDVFARQAELAQREQASVDDILTIPLALNTDWTPEQVQNELDNNAQGILGYVVRWIDQGVGCSKVPDINDIGLMEDRATLRISSQHMTNWLRHGIVTETQVLESLKRMAPVVDRQNANDPLYRPLSPDFDSNIAFQAAVELVIEGTRQPNGYTEPVLHRRRREFKAKNRV
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G 1.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRB2_ARATH
Sequence: MGAPKQKWTPEEEAALKAGVLKHGTGKWRTILSDTEFSLILKSRSNVDLKDKWRNISVTALWGSRKKAKLALKRTPPGTKQDDNNTALTIVALTNDDERAKPTSPGGSGGGSPRTCASKRSITSLDKIIFEAITNLRELRGSDRTSIFLYIEENFKTPPNMKRHVAVRLKHLSSNGTLVKIKHKYRFSSNFIPAGARQKAPQLFLEGNNKKDPTKPEENGANSLTKFRVDGELYMIKGMTAQEAAEAAARAVAEAEFAITEAEQAAKEAERAEAEAEAAQIFAKAAMKALKFRIRNHPW
What is the function of this protein?
Binds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
What are the official names of this protein?
Telomere repeat-binding factor 2, AtTRB2, MYB transcription factor, Telomere-binding protein 3, AtTBP3.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family. SMH subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome. Note=Localized to the nucleolus during interphase.
Protein: MIAB_MYXXD
Sequence: MKRYFIHTFGCQMNVNDSLRMSEVLSQMSYAPTPVPDNADLIILNTCSIREKAEDKMLSALGRYKPVKASRGALIGVGGCVAQQEKDKLLKKVPYLDFVFGPDNIARLPDIIGRVSAERERVVETAFVNSEEYVFPRADPETSRGKVTEFVTVMKGCDNVCSFCIVPHTRGREVSRAFPDVLVEVADLAKVGVREVTLIGQNVNSYAGGISFAQLLLRTAEVPGIERVRFTTSHPHDLSDELIEAFRVQPKITPHFHLPVQCGSDRILKMMRRDYTVVQYLERLAKLREARPGIAVTTDIIVGFPGETEEEFEMTMQLTEQVRYDNQFSFVYSPRPKTGAALREKDWGPVPHEVKIARLERLQKLQRRISGEITAALVGSEVEVMVEGHSRYDATKRFGRTPENRTVNFDGDAPAGSFVTVKVERATPNQLAGKQVALLKPPTVEPLPVPMAEAPFHVVAEA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.