PharMolix/UniProtQA huggingface dataset:
Protein: HSLO_SHISS
Sequence: MPQHDQLHRYLFENFAVRGELVTVSETLQQILENHDYPQPVKNVLAELLVATSLLTATLKFDGDITVQLQGDGPMNLAVINGNNNQQMRGVARVQGEIPENADLKTLVGNGYVVITITPSEGERYQGVVGLEGDTLAACLEDYFMRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNAQQDDFDHLATLTETIKTEELLTLPANEVLWRLYHEEEVTVYDPQDVEFKCTCSRERCADALKTLPDEEVDSILAEDGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GONS2_ARATH
Sequence: MSAVKLEAIVCHEPDESELSHLSDNGSKTKNGVVFQLLDQKSSEHRWFSERFLRWRRRYLPVDGDNRRDHGSVKQSGPLVSGAAYCISSCSMIILNKIVLSSYNFNAGVSLMLYQNLISCLVVAVLDISGVVSVEKFNWKLIRVWMPVNVIFVGMLVSGMYSLKYINVAMVTILKNATNILTGIGEVYMFRKRQNNKVWAAMFMMIISAISGGITDLTFDAVGYTWQLANCFLTASYSLTLRRVMDKAKQSTKSGSLNEVSMVLLNNLLSIPFGIILIILLGEWRYVISTDVTKDSMFWVVATASGFLGLAISFTSMWFLHQTGPTTYSLVGSLNKVPISLAGLVLFNVPLSLPNLFSILFGLFAGVVFARAKMS
What is the function of this protein?
GDP-mannose transporter that may be involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter GONST2, Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 2.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. GDP-Mannose:GMP antiporter (GMA) (TC 2.A.7.13) subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: ACCD_PSEPK
Sequence: MSNWLVDKLIPSIMRSEVKKSSVPEGLWHKCPSCEAVLYRPELEKTLDVCPKCNHHMRIGARARIDIFLDAEGRAELGADLEPVDRLKFRDGKKYKDRLTAAQKQTGEKDALISMSGTLMGMPIVVSAFEFSFMGGSMGAIVGERFVRAANYALENRCPMVCFSASGGARMQEALISLMQMAKTSAVLARLREEGIPFISVLTDPVYGGVSASLAMLGDVIVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGAIDLIISRGELRPRLARLLAQMTGQQTPEEAREAAAVA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_HIPCM
Sequence: MAKIKARDLRGKKKEELLKQLDDLKNELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTVITQTQKENLRKFYKGKKYKPLDLRPKKTRALRRRLNKHEESLRTKKQQRKDLLYSIRKFAVKA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_PSEA8
Sequence: MTDYKATLNLPETAFPMKAGLPQREPETLKFWNDIGLYQKLRAIGGDRPKFVLHDGPPYANGSIHIGHAVNKILKDIIVRSKTLAGYDAPYVPGWDCHGLPIEHKVETTHGKNLPADKTRELCREYAAEQIEGQKADFIRLGVLGEWDNPYKTMNFANEANEIRALAEMVKQDFVFKGLKPVNWCFDCGSALAEAEVEYADKKSPTIDVGFPVADADKLAAAFGLAALDKPAQIVIWTTTPWTIPANQALNVHPEIDYALVDAGDRYLVLAEALVESCLARYQREGKVVATAKGEALELINFRHPFYERLSPVYLADYVALDAGTGIVHSSPAYGEDDFYTCKRYGMSNDDILSPVQSNGVYVDSLPFFGGQFIWKANPNVVAKLEEVGSLLAHETINHSYMHCWRHKTPLIYRATAQWFVGMDKQPRQGASLRERALEAITQTEFVPGWGQARLHGMIAGRPDWCISRQRNWGVPIPFFLHKASGELHPRTVELMEEVAQRVEKEGIEAWFKLDAAELLGEDAAQYEKINDTLDVWFDSGTTHWHVLRGSHRIGHASGPVADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRQLLTHGFTVDESGRKMSKSLGNTVVPQTVIDTLGADILRLWVASTDYSGEIAVSQQILQRSADAYRRIRNTTRFLLSNLNGFDPATDLLPPQEMLALDRWAVDRALLLQREIEEAYREYRFWNVYSKVHNFCVQELGGFYLDIIKDRQYTTGANSVARRSCQTALFHIAEALVRWIAPILAFTAEEVWKFLPGERAESVMLATWYDGLSELPADVTLNRQYWEQVMAVKAAVNKELENQRAAKAVGGNLQAEVTLYAEDALQVQLAKLGNELRFVLITSTATLAPLSAAPADAVDSEVAGLKLKVVKSTHAKCGRCWHHREDVGQHAAHPDLCGRCIENIEGSGEVRHYA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLJ_ASPFC
Sequence: MGSIDTVGMGQRAIDQIISELSLNEKVALLSGVDAWHTFAIPRLGIPSIRTTDGPNGARGTRYFNGVPSACLPCGTALGATFDRDLIFSLGQLLAAECRAKGAHVLLGPTINIQRGPLGGRGFESFSEDPVLSGLAAASYCSGVQDGGVVPTLKHLVCNDQEHERVAVSALVTPRALREIYLLPFQLAIQGARPGAVMTSYNKVNGLHASENPGLIRDILRGEWGYEGAVISDWFGTYSVADAVNAGLDLEMPGPTRFRGPALMHALTSNKVSEKTLNERVRKVLELVQLASRAGVPEYAPERKLNRPEDRALLRRAAGESVVLLKNDKNDSTNSPILPLDREKTTLVIGPNADLAAYCGGGSASLLAYYTVTPRQGIADKCGAEQVVFSQGCYGHKELPLLGEHLRTIETGQPGYTFRVYTEPPPASGSFKGSDSRTPVDELHMTNSSAFLMDYSHPQISGDTYYATLEGTFEPPESGVYEFGLTVAGTGLLYIDGVLVVDNKTVQRAGTSFFGIGTVEERGERYLEAGKKHHVFVEFGTAPTSNLQHHHGVVSFGPGGLRLGGCRKLDTDTAIQQAVQSAAQADQVVVCVGLSGDWESEGFDRPHMDLPPGTEELVNAVLAVQPNAVIVVQSGTPVTMPWADKAKALLQAWYGGNEAGNGIADVLFGDVNPSAKLPLTFPRELSQNPSYLSYRSERGRVLYSEDIYVGYRYYDTTGQPPLFRFGHGLSYSTFHLRDLTVRETAPYAANIKESSLRVSVTVSNTSARPGAEVVLVYVRPPAAACSVGRPVRELKGYEKVMLQPGETREVSITIPLGLATSFWDEGCDAWLSEKGLYFVEAVGTGEGNTLVAPLTVQVSRVWNGL
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase J, Beta-D-glucoside glucohydrolase J, Cellobiase J, Gentiobiase J.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS14_EHRRG
Sequence: MMSRKSVIQRNLKRISICDRLKSKREKLRAIIKDQSISMNDRFLAQVKLSKLPRDSSYIRIRNRCLITGRPRGCYRKFKVSRIVLRQLGSIGQIPGLTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: EUTQ_SALTY
Sequence: MKKLITANDIRAAHARGEQAMSVVLRASIITPEAREVAELLGFTITECDESVPASTSAQACKSESQRIREAIIAQLPEGQFTESLVAQLMEKVLKEKQSLELGTMQPSFTSVTGKGGVKVIDGSSVKFGRFDGAEPHCVGLTDLVTEQDGSSMAAGFMQWDNAFFPWTLNYDEIDMVLEGELHVRHEGETMIAKAGDVMFIPKGSSIEFGTPTSVRFLYVAWPANWQSV
What is the function of this protein?
Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source.  It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078).  EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
What are the official names of this protein?
Acetate kinase EutQ, Ethanolamine utilization protein EutQ.
What is the protein family that this protein belongs to?
Belongs to the EutQ cupin-like family.
What are the subcellular locations of this protein?
Bacterial microcompartment. Note=May be found on the cytoplasmic face of the BMC.
Protein: DDX5_MACFA
Sequence: MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERGWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ
What is the function of this protein?
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner.  Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10.  The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.  Involved in transcriptional regulation; the function is independent of the RNA helicase activity.  Transcriptional coactivator for androgen receptor AR but probably not ESR1.  Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.  Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis.  Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation.  Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1.  As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX5, DEAD box protein 5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm.
Protein: ENDSF_BACTN
Sequence: MGGLTLFAAQGCKAPKQVAEQAEHPNIIYVFPDQYRNQAMGFWNQEGFRDKVNFRGDPVHTPNIDTFARESMVLTSAQSNCPLSSPHRGMLLTGMYPNRSGVPLNCNSTRPISSLRDDAECIGDVFSKAGYDCAYFGKLHADFPTPNDPENPGQYVETQRPVWDAYTPKEQRHGFNYWYSYGTFDEHKNPHYWDTDGKRHDPKEWSPLHESGKVVSYLKNEGNVRDTKKPFFIMVGMNPPHSPYRSLNDCEEQDFNLYKDQPLDSLLIRPNVDLNMKKAESVRYYFASVTGVDRAFGQILEALKQLGLDKNTVVIFASDHGETMCSQRTDDPKNSPYSESMNIPFLVRFPGKIQPRVDDLLLSAPDIMPTVLGLCGLGDSIPSEVQGRNFAPLFFDEKAEIVRPAGALYIQNLDGEKDKDGLVQSYFPSSRGIKTARYTLALYIDRKTKQLKKSLLFDDVNDPYQLNNLPLDENKEVVEQLYREMGTMLKEIDDPWYTEKILSDRIPY
What is the function of this protein?
Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS).  Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers.  Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587).  GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B. thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).
What are the official names of this protein?
Endo-4-O-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
Protein: RL30_METPP
Sequence: MTDKKTVKVKLVRSPIGTKESHRATVRGLGLRQIGSERVLEDTPAVRGMINKVSYLVQVL
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: SPI1_MYXVL
Sequence: MKYLVLVLCLTSCACRDIGLWTFRYVYNESDNVVFSPYGLTSALSVLRIAAGGNTKREIDVPESVVEDSDAFLALRELFVDASVPLRPEFTAEFSSRFNTSVQRVTFNSENVKDVINSYVKDKTGGDVPRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFYSGNVTYKVRMMNKIDTLKTETFTLRNVGYSVTELPYKRRQTAMLLVVPDDLGEIVRALDLSLVRFWIRNMRKDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFGQASPSNDLYVTKVLQTSKIEADERGTTASSDTAITLIPRNALTAIVANKPFMFLIYHKPTTTVLFMGTITKGEKVIYDTEGRDDVVSSV
What is the function of this protein?
Important in virulence.
What are the official names of this protein?
Serine proteinase inhibitor 1, Serp-1, Serpin-1.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Poxviruses subfamily.
Protein: LAC15_ARATH
Sequence: MSHSFFNLFLISLFLYNNCIAHHYTFTVREVPYTKLCSTKAILTVNSQFPGPIIKVHKGDTIYVNVQNRASENITMHWHGVEQPRNPWSDGPEYITQCPIRPGSDFLYKVIFSIEDTTVWWHAHSSWTRATVHGLIFVYPRPPQILPFPKADHEVPIILGEWWKRDVREVVEEFVRTGGAPNVSDALTINGHPGFLYPCSKSDTFHLTVEKGKTYRIRMVNAAMNLPLFFAIANHSLTVVSADGHYIKPIKATYITISPGETLDMLLHADQDPERTYYMAARAYQSGNIDFNNSTTIGILSYTSSCKAKTSSFSGYYPTLPFYNDTSAAFGFFTKIKCLFSGQVPVQISRRIITTVSINLRMCPQNSCEGPNGSRLAASMNNISFVTPSHVDILKAYYYHIKGVYGTRFPEFPPLIFNFTAENQPLFLETPRLATEVKVIEFGQVVELVIQGTSLVGGGLDHPMHLHGFSFYVVGVGFGNYNISEEDPSSRYNLYDPPYKNTMTVPRNGWIAIRFVADNPGVWFMHCHLDRHQTWGMNVVFIVKNGREPNQQILPPPDDLPPCYE
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (By similarity).  Involved in lignin synthesis in seed coats, in seed coat permeability, in seed germination, and in root elongation.  Required for the seed coat (testa) brown pigmentation by mediating the polymerization of proanthocyanidin (tannin) from its monomer precursor epicatechin.  Slightly promotes seed dormancy.
What are the official names of this protein?
Laccase-15, Benzenediol:oxygen oxidoreductase 15, Diphenol oxidase 15, Protein TRANSPARENT TESTA 10, Urishiol oxidase 15.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: RL331_STAAM
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CLRA_IDEDE
Sequence: MNSPDEHNGRRRFLQFSAAALASAAASPSLWAFSKIQPIEDPLKDYPYRDWEDLYRKEWTWDSVGVMTHSNGCVAGCAWNVFVKNGIPMREEQISKYPQLPGIPDMNPRGCQKGAVYCSWSKQPDHIKWPLKRVGERGERKWKRISWDEALTEIADKIIDTTVKRGPGNIYIPKRPFAVITNTAYTRMTKLLGAISPDATSMTGDLYTGIQTVRVPASTVSTFDDWFTSDLILMWHKNPIVTRIPDAHFLMEARYNGARLVNISADYNPSSIHSDLFVPVTSGTDSHLAAALVNVLIAGKHYKADYLKEQTALPFLVRTDNGKFLREKDFKADGSDQVFYVWDTKAGKAVLAPGSMGSKDKTLKLGTIDPALEGNFETHGIKVTTVFERLKAEITPYTPEATQATTGVHPSVVRQLAGWIAECKALRILDGYNNQKHFDGFQCGRLKILILTLIGHHGTTGSIDTTFEGWRLEGNSELGTVKGKPGRSVSAVLAQWVWGEQYQRSKDYFNDAQLREELGFGVDEMESMRKESEANGWMPNWQSIKEPVVSITGGINMFATSNGYQHLRDNFLKRCELNVVVDFRLNSGAMYADIVLPAAENTEKLDIRETSVTRFIHAFGQPVKPMYERKTDWQIMVALAAKIQERAKARGIARVDDPEIKSGIDFDKIYDEFTMNGKVVTDEQAVRFVMDNSKALGPGTYEEVMKNGFVAVGPSAGKTGPVPKDKPYRPFTVNVTDKKPYGTLTGRLQFYVDHDWFQRLGATVPKPQYRGGVLGPKKYPFVRNSPHARWGVHSFARTEQWMLRHQRGEPDVRMSPKAMAAKGIKDGDMVRIFNDSGEFFAVVKAMPALPDNMLFTEHGWEQYQYKNMTHYNMVSSELINPLELVGGYGHIKYTSGGFNPNRIFYETTVDVEKA
What is the function of this protein?
Terminal reductase that allows anaerobic growth on chlorate as the sole respiratory oxidant.
What are the official names of this protein?
Chlorate reductase subunit alpha, Chlorate reductase molybdenum subunit.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DEFA_ZOPAT
Sequence: FTCDVLGFEIAGTKLNSAACGAHCLALGRRGGYCNSKSVCVCR
What is the function of this protein?
Involved in anti Gram-positive activity of immune hemolymph of Z. atratus.
What are the official names of this protein?
Defensin, isoforms B and C.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RAB8A_PONAB
Sequence: MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKRDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCVLL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab is involved in polarized vesicular trafficking and neurotransmitter release.  Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.  Regulates the compacted morphology of the Golgi (By similarity).  Together with MYO5B and RAB11A participates in epithelial cell polarization.  Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity).  Together with MICALL2, may also regulate adherens junction assembly (By similarity).  May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity).  Involved in autophagy (By similarity).
What are the official names of this protein?
Ras-related protein Rab-8A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Midbody. Cytoplasm. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Non-phosphorylated RAB8A predominantly localizes to the cytoplasm whereas phosphorylated RAB8A localizes to the membrane (By similarity).
Protein: IAA1_STRGS
Sequence: DAGNRIAAPACVHFTADWRYTFVTNDCSIDYSVTVAYGDGTDVPCRSANPGDILTFPGYGTRGNEVLGAVLCATDGSA
What is the function of this protein?
Inhibits mammalian alpha-amylases specifically but has no action on plant and microbial alpha-amylases.
What are the official names of this protein?
Alpha-amylase inhibitor Haim-1, Haim I.
Protein: RSLAB_MOUSE
Sequence: MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTTRRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADACCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
What is the function of this protein?
May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.
What are the official names of this protein?
Ras-like protein family member 10B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RPF1_RAT
Sequence: MAKAGEKSGGGGKRGLKRKAPAEEPQETAVASDGTAESGVQSAKAAAFPPGFSISEIKNKQRRHLMFTRWKQQQRKEKLAAKKKLKREREALGDKAPPKPVPKTIDNQRVYDETTVDPNDEEVAYDEATDEFASYFNRQTSPKILITTSDRPHGRTVRLCEQLSTVIPDSHVYYRRGLALKKIIPQCIARDFTDLIVINEDRKTPNGLILSHLPNGPTAHFKMSSVRLRKEIKRRGKDPTEHVPEIILNNFTTRLGHSIGRMFASLFPHNPQFIGRQVATFHNQRDYIFFRFHRYIFKSEKKVGIQELGPRFTLKLRSLQKGTFDSKYGEYEWVHKVCAYCSKAI
What is the function of this protein?
May be required for ribosome biogenesis.
What are the official names of this protein?
Ribosome production factor 1, Brix domain-containing protein 5, Ribosome biogenesis protein RPF1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EX7S_YERPS
Sequence: MPKKAASPEIKAASFETSLSELEQIVTRLESGELPLEDALNEFERGVQLARQGQQTLLQAEQRVQILLSDDVDAPLKPFTPDTE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_LUMTE
Sequence: MILTSFMLMMIATTFTLYLASTPIVLGVNILMMALLLASTFASFMSSWFAFLIFLIYIGGMLVMFAYFLALTPNQQISNFNIMPYALITLLTFSALTYTTNIKIPTFSDISQGNSILYMSSTAPFLILLALILLLTMVIVVKLTSRSSGPLRPFSP
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: TRMB_BIFLO
Sequence: MTNPESTAIDPVAAMGTDHTEAPAHPLHKVLSFVRRSGRLDDRLQRAWDNYAGTYLLDIAAGNLLDVREGVTLDRAFVESAWGNDNPLIVEIGTGQGENVVAAAAAHPETNFLALEVYDPGVAHTLLLAGKQGLTNIRVAQVNAPELFKVTAAGTVAEVWTFFPDPWPKKKHHKRRIVQKAMAGDIHRALVTDGVWRIATDIEDYALHVHEVMDGLDGWKNLGSVTVSLPLEHVGKGNADMAADMPHADFTESERFEGRVLTNFEKKGLAAGRVIHDFTYQAVTLN
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ATPF_ACIB3
Sequence: MNINLTLIGQAIAFAFFVAFCMKFVWPPLINAISERQRKIADGLNAAEKAKADLADAQAQVKQELDAAKAQAAQLIEQANRRAAQLIEEARTQAAAEGERIRQQAKEAVDQEINSAREELRQQVAALAVTGAEKILNQQVDAEAHNAMLSQLAAKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: QUEC_RICRS
Sequence: MKKKAVILLSGGPDSTTVLEIVSKTDYEIYALSFNYHRRNSLEVQKIQGLIKDYNVKQHRVINIDLQSFIGSALTDDNIDVPKFKNTDQLPSDIPVTYVPARNTIFLSYALGVAEVIGARDIFIGVHTNDYTNYPDCRPEYIKSFEAMANLATRVGVNGEKITIHAPLINMTKEQIIKKGLELGVDYSKTISCYDPTEDGLSCGQCLSCIVRLDAFKKNNVQDPIQYV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.