PharMolix/UniProtQA huggingface dataset:
Protein: CLPS_BURMS
Sequence: MAIIPDKQDSSVLERKEQKLKPPSMYKVVLLNDDFTPMEFVVMVVQEYFKKDRETATQIMLKVHREGRGVCGVYTRDIASTKVEQVVTHARQAGHPLQCVMEEA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: MACB1_PSEU2
Sequence: MRTPLIDLRGIRKSYGGGDSPLVNVLRGIDLSIHTGEFVAIVGASGSGKSTLMNILGCLDRPTSGEYLFAGENVAALGSDELAWLRREAFGFVFQGYHLIPSGSAQENVEMPAIYAGTPAAERHARAAALLDRLGLASRTGNRPHQLSGGQQQRVSIARALMNGGHIILADEPTGALDSHSGAEVMTLLDELASQGHVVILITHDREVAARAKRVIEISDGLVISDTAQDASDVQRSVNPAALQAVDLRKRLSEGSGSQSAWQGELFDAIRAAWRVMWINRFRTALTLLGIVIGVASVVVMLAVGEGSKRQVMAQMSSFGSNIIYLNGKAPNPRAPKGVITLEEVAALGELPEVKMIMPVNGGQAGVRYGNLDHSSYVGGNDTHFPAIFNWPVVEGSYFSEADEQNAAAVAVIGYKVRQKLFGEQSDPVGQYILIENVPFQVVGVLQEKGATSGDLDSDNRIAIPYSSASIRLFGTQDPEYITIATRDANNVKQAEQSIRNLLQQLHHGKQDYELTNNAAMIQAEARTQNTLSLMLGSIAAISLLVGGIGVMNIMLMTVRERTREIGIRMATGARQSDILRQFLTEAVMLSVVGGLAGIVLALGMGAALLLSKVAVAFTLPAVAGAFACALITGVIFGFMPARKAARLDPVAALTSE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DSK1_SCHPO
Sequence: MGSDGSSLSPKVSQPGHTEIVDHVSEKVITNGKNVNKKVNAEVDGKSMVEKVKTHEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHIEAPATTSSPTSNTSSSKTRNNTGYTAKAPIIKRGQSVDNSAQERKTFAKNPTKNSKPAGQVIPSSPFTSTLSRFPSLEGAVSEISLRDSQKHNSHPNSPFSSGDNSLILDGVNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACIIFELLTGDYLFDPRNGNSYSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQKYHFSAELAQQISDFLSPMLCFDPAKRTNAGYMSNSPWLREVADPTFKIETTGATGEDVPGWATEIR
What is the function of this protein?
May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity.  Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2.  Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle.
What are the official names of this protein?
Protein kinase dsk1, Dis1-suppressing protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Enriched in the nucleus in mitotically arrested mutant and wild-type mitotic cells but cytoplasmic enriched in cells at other cell-cycle stages.
Protein: LIPB_SALAI
Sequence: MTTTTSDLTVLRAGTLDYEAAWEEQRRLHESVVTDKHGDAVLLLEHPSVYTAGKRTEPWDRPMDGTPVIDVDRGGKITWHGPGQLVGYPILRLPDPVDVVAYVRRVEQMLIDVCAEFGLVAGRIEGRSGVWVPADDRGPARKVAAIGIRVARGVTLHGFSLNCDCDLTYYDRIVPCGIRDAGVTSLAAELGRPVTVADALPVVERHLPTLVGA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM41B_RAT
Sequence: MAKGRVAERSQTEMLHSTPAGDRAVGTQGSAAPGNKDHLKEKPCVEAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSVFILMILALLSILPAIFQKKLKQKFE
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes.  Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine.  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly.  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity).  Required for normal motor neuron development (By similarity).
What are the official names of this protein?
Transmembrane protein 41B.
What is the protein family that this protein belongs to?
Belongs to the TMEM41 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endomembrane system. Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria.
Protein: MFD_RICCN
Sequence: MLQQKFPAAAKSFFAIDNFTKNLKQDFILSASNEEEALQLYKQALFFSSNENIYYFPSYNTIPYDHTSPNANILSRRAETLIKLTTNNSNSNKLLITHTANLLNKLPPKDFFSKYFLKLSPKMKFTTDELAMFLVENSFTRNASSIDVGEFAVRGEIIDIILSGPKAYRIHFSWGYIESIKEFDIDTQISTKSCRELIISPANEIVLNSETIGNFKNNYLRNFGVNHTDNALYEAVISGRKFTGYEQLLPLFYDSCSNLIDYLNDPIFIFDNLSKKAILEFEHSYNDFYSARSEANKLKFNSFYPTLSPTSLYFTASEITELLEQKNNILLTFENSEQASLIKNIAATSFIEKKTVFDKLFEVIKANSHKKIIIGSSVLSSFERIKSIIQNYEYKYNEINKLDEAKASIINVAIIPLNQSFYTKEYLFITASELLEEKPSSTNTNKKLKNILLELDNLAEGEFVVHKDHGIGQFLKLEALEIKGKPHDFLKILYAGNDKLYIPVESIEVIKKYGNDNAELDKLGSVSWQRSKAKLKKRIKEIALHLIQIAAKRKLNSSASVEFDLEEYDKFCANFPFSETEDQLIAINDIKEDLRNGMLMDRLICGDVGFGKTEVAMRAVFMVAKSLNEHLPQVAVVVPTTILCSQHFSRFIERFKGFGLNIKQLSSVISSKEAKIIRSELESGKINIIIGTHSLLHKNIKFFNLKLLIIDEEQHFGVGQKEFLKSLKSSSHVLAMSATPIPRTLQMSMTGLKELSIIATPPLNRLEVHTSVMPYDPVIIRDALLREHFRGGRSFYVVPRIKDIEDIAKQLKQIVPELSYKIAYGKMTPSKIDEVMSEFYAGKFDILVSTTIIESGIDIAEANTMIIHNADMLGLSQLYQLRGRIGRGKMRGYAYLTVASHKKMTSHSLRRLEIIQNSCALGSGFTIASRDMDLRGFGNLIGEEQSGQIKEVGTELYQEMLEEQIAIFKDESIVSEQPFIPTINLGLSVFIPDNYVADAALKLGLYRRIGNLSNEIEVETFKDEMIDRFGLLPIEFNNLLDIVKIKLLCFKLNIENLDSGDNGFVIKFYKNADMTDKILKFVTTYSNQAKIKPDNKLVYIKKLVDKNIIVEANQLLWNLSEV
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLPA_SYNY3
Sequence: MKGINVCRSIAGVIGTASLTTLVWGNCPSGLLALNAITQADAPTAVSENNSSLAPLESSVTATSSTPAPAFQDTELISLVPHQGPENRLAVTLRVNQIPVVTFLGTATELAALSNDQVTDTMERAQTVARRLDELSGAEFFDPSTIKVGLDATTRQLVVKSEDEILLTINKNTVLPEKKLSAPETALQTANRLRRLLGGAEPIVALPAALQVARVNTFDAAATIKRIKGGIASWYGPGFHGRRTANGERFNQNALTAAHRTLPFGTRVKVTNLRNGQSVVVRINDRGPFTGGRVIDLSAGAARAIGIHSSGVGNVALDIVQ
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Probable endolytic peptidoglycan transglycosylase RlpA.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
Protein: TTCA_SHIF8
Sequence: MSQNQEISKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGTTKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVNGGDLAFDREEIPLQPAGWQPEEDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLOD1_CHICK
Sequence: MVPPAVLLPWVVLPLLGVQGGSGSKQEENLLVLTVATKQTEGFRRFRRSAQFFNYKIQVLGLDEEWKGGDDKKPAGGGQKVRLLKSALKQHADKEDLVILFIESYDVLFASGPTELLKKFKQAKSKVVFSAENYIYPDRKLEAKYPPVRDGKRFLGSGGFIGYAPNLKKLVEEWKGKDDDSDQLFYTKIFLDPEKRENINISLDHRSRIFQNLNGALDEVVLKFENARVRARNLLYDTLPVIIHGNGPTKLQLNYLGNYIPQIWTFETGCTVCDEGLRSLTGIKDEALPMILIGIFIEQPTPFLSQFFLRLRNLHYPKQRIQIFIHNHEEHHSMQVDSFVKEHSKEYLAMKVIGPDDEVENAEARNLGMDLCRKDPDCDYYFSLDAEVVLKNTETLRILIEQNKSVIAPLVSRHEKLWSNFWGALSPDGYYARSEDYVDIVQRRRVGLWNVPYISSVYMVKGKVLRSELDEGDLFHGGKLDADMAFCHNVRNQGVFMYLTNRHQFGHILSLENYQTTHLHNDLWQIFSNPEDWREKYIHENYTAALKGKLVEMPCPDVYWFPIFTDTACDELVEEMEHYGKWSTGDNTDSRIQGGYENVPTIDIHMNQIGFEREWYKFLLDYIAPITEKLYPGYYTKTQFELAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGIDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTKGTRYIAVSFIDP
What is the function of this protein?
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens.  These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
What are the official names of this protein?
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, Lysyl hydroxylase 1, LH1.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: TBD2A_AILME
Sequence: MDGAHENAAESSSSVPRSEEPACSAGGPEVLPPEESEGCAGSLDAAPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPSRIITLKAATKQVMLYWLQQLQTKRWEFHSSPPAPPAAPDAAPAGNGPTLRLELEQEEEELEDFLSPVRTPPGLVGAAAALQPVPTKPLALQNISLKHLGTEIQNTMYNIRSNRQAQGTGHGPPGEDPPLSAEPQRAEWPLPSDPGTPGKDPADSPKPTPKSSLTANLIQKAKRPNNTFPLFAEGLTRTRTAQEKILALEQQVLMLTKELKSQKELVRILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGKRVEALERERESLAQTAGLREQQVQELQRHVQQLLEKNQAKQQVICKLSEKVTWDFTHPPTQPPVPLGAADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRRVAEKEKALLMKCAYLQAKNCQVESKYLAGLRRLQEAAGGEATESSELLRQLTQEALQWEAGEASADGVELSPISEYDEYGFLTVPNYEMEDLKLLAKIQALEVHSHHLLAHEAVERPLRERWAALGDLAPSVELKQLLRAGVPREHRPRVWKWLVQLRVRHLQSPGHYQELLSRGQVREHPAARQIELDLNRTFPNNKHFTCPTSTFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYSKTLTSSQVDQRVLQDLLLEKLPRLMAHLGQYRVDLSFLTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEEEILRLQDSLEIYQYLRFFTKTICNSQKLMTIAFNDMNPFPMKQLRQLRRAHRERLEAELHELEQLKAEYLETQSSRGPAVPDGCTSEDEGEGEA
What is the function of this protein?
Acts as GTPase-activating protein for RAB7A.  Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).
What are the official names of this protein?
TBC1 domain family member 2A.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle. Cell junction.
Protein: RCF1_YEAS8
Sequence: MSRMPSSFDVTERDLDDMTFGERIIYHCKKQPLVPIGCLLTTGAVILAAQNVRLGNKWKAQYYFRWRVGLQAATLVALVAGSFIYGTSGKELKAKEEQLKEKAKMREKLWIQELERREEETEARRKRAELARMKTLENEEEIKNLEKELSDLENKLGKK
What is the function of this protein?
Cytochrome c oxidase subunit required for growth under hypoxic conditions.  Involved in the assembly of the Complex III-Complex IV supercomplex, as well as in the recruitment of COX13 and RCF2 into cytochrome c oxidase.  May also be required for late-stage assembly of the COX12 and COX13 subunits and for cytochrome c oxidase activity (By similarity).
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial, Altered inheritance of mitochondria protein 31.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: PARP9_MOUSE
Sequence: MAYYMDTWAAAPAERPGMIASLSLSFKKAFAELFPQRRRGHSEGDYPPLRGSANNSLEEHYRWQIPIKHNVFEILKSNESQLCEVLQNKFGCISTLSCPTLAGSSSPAQRVFRRTLIPGIELSVWKDDLTRHVVDAVVNAANENLLHGSGLAGSLVKTGGFEIQEESKRIIANVGKISVGGIAITGAGRLPCHLIIHAVGPRWTVTNSQTAIELLKFAIRNILDYVTKYDLRIKTVAIPALSSGIFQFPLDLCTSIILETIRLYFQDKQMFGNLREIHLVSNEDPTVASFKSASESILGRDLSSWGGPETDPASTMTLRIGRGLTLQIVQGCIEMQTTDVIVNSGYMQDFKSGRVAQSILRQAGVEMEKELDKVNLSTDYQEVWVTKGFKLSCQYVFHVAWHSQINKYQILKDAMKSCLEKCLKPDINSISFPALGTGLMDLKKSTAAQIMFEEVFAFAKEHKEKTLTVKIVIFPVDVETYKIFYAEMTKRSNELNLSGNSGALALQWSSGEQRRGGLEAGSPAINLMGVKVGEMCEAQEWIERLLVSLDHHIIENNHILYLGKKEHDVLSELQTSTRVSISETVSPRTATLEIKGPQADLIDAVMRIECMLCDVQEEVAGKREKNLWSLSGQGTNQQEKLDKMEESYTFQRYPASLTQELQDRKKQFEKCGLWVVQVEQIDNKVLLAAFQEKKKMMEERTPKGSGSQRLFQQVPHQFCNTVCRVGFHRMYSTSYNPVYGAGIYFTKSLKNLADKVKKTSSTDKLIYVFEAEVLTGSFCQGNSSNIIPPPLSPGALDVNDSVVDNVSSPETIVVFNGMQAMPLYLWTCTQDRTFSQHPMWSQGYSSGPGMVSSLQSWEWVLNGSSV
What is the function of this protein?
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:27796300).  Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (By similarity).  In addition, positively regulates DTXL3 protein levels (By similarity).  In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (By similarity).  During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (By similarity).  Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity).  In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ) but the complex function is restrained by PARP9 activity (By similarity).  Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (PubMed:28105679).  In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300).  Also suppresses PARP14-mediated STAT6 ADP-ribosylation (By similarity).
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Poly [ADP-ribose] polymerase 9, PARP-9.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.
Protein: NDB4T_LYCMC
Sequence: MKVKCLLAVFLIVLIAAEHCQALFFLPSLIGGLISAIKGRRKRELGTQFRPQQKNFMRREIDLERLFAEMPDY
What is the function of this protein?
Cationic host defense peptide that have antibacterial activity by breaking membranes.  Is more effective on Gram-positive than on Gram-negative bacteria.
What are the official names of this protein?
Antimicrobial peptide 143.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: TMPS_METJA
Sequence: MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFKNNVKNIVIEEVYEEFVDNPYDYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPSETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGNEYINKFIDYFKIGKPELEIEVENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGDTILHKAGYIAFEVVEKALKK
What is the function of this protein?
Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i. e.  a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2. 1. 1. 45).  However, M. jannaschii like most methanogenic Archaea lacks folates, thus the physiological cosubstrate is unknown but is likely one of the non-methylated methanopterin biosynthetic intermediates.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
Protein: RF1_PARL1
Sequence: MIPEERLQSVIARFEAVQSEMNSDVPRDRFVALSKEFSELEPVAAAIGHLLARRREYADAEQLLRVRDMAEMAKEEIARLNEELPRLEHEVQLMLLPKDAADDRNVILEVRAGTGGDEAALFAGDLFRMYERYASNQGWKVELIAASEGEMGGYKEIIAGISGPGVYAKLKFESGVHRVQRVPVTEGGGRIHTSAATVAVLPEAEEVDVEIEDKDLRIDVYRASGAGGQHVNKTESAVRITHLPTGIVVAQQDEKSQHKNKARAMQILRARIFDAERERLDRERSAARKGQVGSGDRSERIRTYNFPQSRVTDHRINLTLHKLDQVLEGEALGELIDALIAEDQAARLAAMGDEA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THSA_ACIB7
Sequence: MFEHEQKIMIDRIVKELEENNFAIFAGAGLSAPAGYVNWKELLRPLSIELNLDIDKETDLVSLAQYYVNENHGRNRLTERLIDEVGVAREPTPNHKILAKLPISTYWTTNYDDLIEKALDNEGKIADKKFTKNHLSQTKKGRSAVVYKMHGDASLPDQAIITKDQYESYPLHFAPFVTALSGDLVSKTFLFLGFSFNDPNLDYILSRIRIHFEQNQRQHYCIFRKVNRADYSNDEDFSYNLLKQQFVIKDLARFSIKVVLIDAWNDLTRILEEITKRFRCKNVFLSGSAHEFGSWGQTATELFLSKLGEVLIQEGFKITSGLGLGIGNAFISGAIKEIYNRKYTKIDDYLTMKVFPQFVADPTERKNIWTAWRKDLLSQTGIALFFMGNKIIKDPESGKQTIVLADGMDEEFHIAHELGLKLIPIGASGYKAKELFNQIISDFDHYYPNSSPKFREAFEKLNEEVDEPVKLLSKIHDVIKLI
What is the function of this protein?
NAD(+) hydrolyzing component (NADase) of the Thoeris antiviral defense system, composed of ThsA and ThsB (maybe J591_1492).  As purified, has NADase activity that is not activated by any tested cADPR isomers; binds 3'cADPR better than 2'cADPR.  It was suggested the purified protein is already in a fully active state (PubMed:36048923).  Upon activation binds and hydrolyzes NAD(+), leading to cell death and inhibition of phage replication (By similarity).
What are the official names of this protein?
NAD(+) hydrolase ThsA, AbThsA, NADase ThsA.
What is the protein family that this protein belongs to?
Belongs to the soluble Thoeris ThsA family.
Protein: HEM3_ACIF5
Sequence: MPHSLRIGTRASPLAVWQAEHVRAALLRLHPGMAVEIITMTTSGDVLLDAPLHALGGKGLFVKEIEDALQQRRVDVAVHSMKDVPALQPDGLEIVAIMAREDVRDAFVSNTFLHPDALPEGARVGSSSLRRRAQLLERYPHLRVEDLRGNVATRLRRLDEGHYDAIILAAAGLKRLGLPDRITHLLDIDRSLPAVGQGAIGIEARSDDRRTRELLAPLADADTQNCVLAERSMNQVLGGDCRLPVAALARWQGPQMLLRGLVATPDGRRVLHAEAKGSDPVALGMAVAAALVAQGAAEIIEDVRNA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PRMA_PROMS
Sequence: MTIKDWYKLTFLIESDSEEIIIWKLNELGIFSFSFEYLIKNKNKKEVNIWLPVADWSESSRFGVEKIITKLLNINAPTNQFFDWSIIKEEDWLTSWKKYWAPELVGNHFLILPCWINLNEKFKDKKIIKIDPGAAFGTGSHPSTYLCLEKMDNILFSDKKILDIGSGSGILSVAARLLGAKEVCAVDNDYLAINATKSNFQLNFGNLNNLNTYLGSFNEVILKNQLKQFDFVLCNILAEVIKEMIPNIYKCLRNNGEVIFSGILNSQKDEIIKILIQNDLKLLDVSTRKDWACISAQKASDPT
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAT2_ARATH
Sequence: MDPKSPEFIIDQPLKILGFVFDELSATRVSGHLTLTEKCCQPFKVLHGGVSALIAEALASLGAGIASGFKRVAGIHLSIHHLRPAALGEIVFAESFPVSVGKNIQVWEVRLWKAKKTETPDNKIMVSTSRVTLFCGLPIPDHVKDAPDELKKVISKL
What is the function of this protein?
Catalyzes the hydrolysis of the thioester bond of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) in peroxisomes, a necessary step to form the naphthoquinone ring of phylloquinone (vitamin K(1)).  Displayed also slight thioesterase activity towards benzoyl-CoA.  Is not active on phenylacetyl-CoA, succinyl-CoA and palmitoyl-CoA thioesters.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA thioesterase 2, AtDHNAT2, DHNA-CoA thioesterase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: MEN1_EUPNO
Sequence: NPEDWFTPDTCAYGDSNTAWTTCTTPGQTCYTCCSSCFDVVGEQACQMSAQC
What is the function of this protein?
Mating ciliate pheromones (or gamones) are diffusible extracellular communication signals that distinguish different intraspecific classes of cells commonly referred to as 'mating types'.  They prepare the latter for conjugation by changing their cell surface properties.
What are the official names of this protein?
Mating pheromone En-1.
What are the subcellular locations of this protein?
Secreted.
Protein: ASSY_CORGL
Sequence: MTNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESIVVDAKDEFAEEYCLPTIKANGMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTGKGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAEENNVPIEQSVKSPFSIDQNVWGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAIEELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKRGVDARWAEEVYDGLWFGPLKRSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYDFNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGNN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_OCEIH
Sequence: MAVKLNATKREDLTKSATKQIRLSGRVPAVVYGKAKDPKNVSVDSVDLVKTVRDEGRNAIISLQVENSSVDVMLHDYQIDPIKDELLHADFYVVNMSEEMDVNVAVRLDGETKGEKEGGVLQQPFYEILVRAKPNNIPEEIVIDVSDLDVGDSVSVADIKVDGNYEILEDPDTSVASVTPPTTEEDLDTDDVDENAEPELVGAENDSADEESENK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL7_PELPD
Sequence: MAEITKQDVIEYIEKMSVLELSELVKELEEKFGVSAAAPVAVAAAGPATADAAAAEEKTEFDVILKAAGANKINVIKVVRALTSLGLKEAKDLVDGAPGAVKTGVSKQEAEDAQKQLVEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.