PharMolix/UniProtQA huggingface dataset:
Protein: PSBN_NICTO
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RBFA_THEP1
Sequence: MNPAYRKAMLESEIQKLLMEALQQLRDPRLKKDFVTFSRVELSKDKRYADVYVSFLGTPEERKETVEILNRAKGFFRTFISKNLRLYVAPEIRFYEDKGIEASVKVHQLLVQLGYDPLKDKEKKEEDKEEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHH_DEVMA
Sequence: VMNLWPGIRLRVTEGWDEDGHHSEESLHYEGRAVDITTEDRDRNKYAMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Indian hedgehog protein, IHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Indian hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Indian hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: APX1_PEA
Sequence: MGKSYPTVSPDYQKAIEKAKRKLRGFIAEKKCAPLILRLAWHSAGTFDSKTKTGGPFGTIKHQAELAHGANNGLDIAVRLLEPIKEQFPIVSYADFYQLAGVVAVEITGGPEVPFHPGREDKPEPPPEGRLPDATKGSDHLRDVFGKAMGLSDQDIVALSGGHTIGAAHKERSGFEGPWTSNPLIFDNSYFTELLTGEKDGLLQLPSDKALLTDSVFRPLVEKYAADEDVFFADYAEAHLKLSELGFAEA
What is the function of this protein?
Plays a key role in hydrogen peroxide removal.
What are the official names of this protein?
L-ascorbate peroxidase, cytosolic, AP, PsAPx01.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_CLOPE
Sequence: MYEYLDRRYALALYEVAEEKNKVEEYLNDLREICDIIYGNNELYEIIKHPQISTVRKKKTFRNIFEGKIDDELLSFLMVLIEKDRILYLREKLKEMEKIHLERNNTLLAEVKSVVPLTEDEVTRLVAKLENKYSKKILLKQEIDKSIIGGLYVRVGDDVIDGTVKSRLDDMKQIMLKRE
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RRF_ACIAD
Sequence: MINDLKKDSEQRMQKTLESLEQGFAKVRTGRAHPSILNGVMVPYYGSDVPLNQVANVGIEDSRTLVVQPFERTMVSAIDKAIRESDLGLNPITADSIRVPLPALTEETRRDMQKVARSEAENAKVAIRNIRRDVLGDLKSLLKDKEISEDDERRAGDDIQKITDKYVAEVDKRLAAKEAELMKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCDAA_HUMAN
Sequence: MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSPRQRLLVLVKDHGEPSLTATATVLVSLVEGSQAPKASSRASVGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRVCSGEGLPKADLMAFSPSLPPCPMVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-10, PCDH-alpha-10.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: THIC_EHRCJ
Sequence: MILYNIFLVKMKVDFINTVFPSSTKEYIPGTIYNNIKVGMRKIHFNDNTESILVYDTGGLHTDQNVEVDINHGITKLRLNWIIDRQDVEYYERQPVLNSEHIFTSQSNKVLRANSTKPVTQIFYARNNIITPEMEYIAIRENSLRQKILSYKPTVMSPEITPEFVRQEVASGRAIIPANINHPESEPMIIGKNFLVKINANIGNSVVSSNIEEEVQKMIHAITYGADTVMDLSTGNNIHDIREWIIRNSPVPIGTVPIYQALNKVNGVVGDLNFNVFKETLIEQAEQGVDYFTIHAGVLKNYISHTDNRLTGIVSRGGAIMAHWCTIHNKENFLYTNFEEICDIMKRYDIAFSLGDGLRPGSIADANDTAQFLELKTLGELTDIAWQHDCQAMIEGPGHVPMHLIKENMEKQIHFCKEAPFYTLGPLTTDIAPGYDHITSAIGAAITGWYGTSMLCYVTPKEHLGLPNIQDVKDGVIAYKIAAHAADLAKGNPSAYIRDYALSYARFNFKWHDQFNLSLDPETARSLHDESLPSEHAKSAHFCSMCGPKFCSMKLTHHLKEHSTG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PRI2_DICDI
Sequence: MLRAGKKTNSQTSTSNDACSLLYINVPDFNCNMSQIENYCIDRFNLLNEVSKLKDTLSAQKSNTSKDNEDFRNLSSRFLGSTKDEQFKIKDELSHYCLRLAMCDSTDRNWFITTESILLANRLNQSDLTTIISSFKGFGWSPVSQEEYEQYQDDLGYLVKKANLNLNEVNNTHFYKLPFQDIPKLIDTKKAIIIKGEAYIYISNFKDMVIHTFKNYMNFALDRIKADKTRIKEEFPELIQFFTTLPKAGDGTNKPQLGNTKHIRKEDVSPLSKTSFPMCMRVMYDSLVETSSLKYEGRLQFGTFLKGIGLPYDEAINFWRIAFSKRVSNTDFDKEYLYNIRHNYGLEGKSTNYSPYSCPRIISKSPHNGDKLVHGCPYIQSLERLEQKLLDLGIDDFQRIQILEATKTSPNVACTKHFNFLHPNNTLTKLINHPNQFYDQSMEYYKTLEEKKSAKQSNNKENENQSIDEK
What is the function of this protein?
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
What are the official names of this protein?
DNA primase large subunit.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: BRIX_METTH
Sequence: MLLTTSRKPSQRTRSFSQRLSRIMGWRYINRGKMSLRDVLIEARGPVAVVSERHGNPARITFLDERGGERGYILFNPSFEMKKPELADKAVRVSSCPPGSEGLCNLMGLEVDESSSRDAWSIRTDEEYAWVMELMDARGTPAGFKLLIRDFRVGE
What is the function of this protein?
Probably involved in the biogenesis of the ribosome.
What are the official names of this protein?
Probable Brix domain-containing ribosomal biogenesis protein.
Protein: RL6_ECO24
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SYH_ECOLI
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPNA_PENCH
Sequence: MASTPKANVPKIDVSPLFGDNMEEKMKVARAIDAASRDTGFFYAVNHGVDVKRLSNKTREFHFSITDEEKWDLAIRAYNKEHQDQIRAGYYLSIPEKKAVESFCYLNPNFKPDHPLIQSKTPTHEVNVWPDEKKHPGFREFAEQYYWDVFGLSSALLRGYALALGKEEDFFSRHFKKEDALSSVVLIRYPYLNPIPPAAIKTAEDGTKLSFEWHEDVSLITVLYQSDVANLQVEMPQGYLDIEADDNAYLVNCGSYMAHITNNYYPAPIHRVKWVNEERQSLPFFVNLGFNDTVQPWDPSKEDGKTDQRPISYGDYLQNGLVSLINKNGQT
What is the function of this protein?
Isopenicillin N synthase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic (PubMed:1368505, PubMed:1369045, PubMed:1588566).  IpnA catalyzes the cyclization of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) to form isopenicillin N (IPN) that contains the beta-lactam nucleus (PubMed:1368505, PubMed:1369045, PubMed:1588566).  The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA.  The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus.  Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase aatA to yield penicillin in the peroxisomal matrix (PubMed:1368505) (Probable).
What are the official names of this protein?
Isopenicillin N synthase, IPNS, Isopenicillin cyclase, Penicillin biosynthetis cluster protein ipnA.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HIS1_RHILO
Sequence: MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEIGQGAVDLGITGEDLVRENLADWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGLADVIVDITTTGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_BACC4
Sequence: MEARLKELKQKALELIEEAKELKGLNDVRVAYLGKKGPITEVLRGMGKLSAEERPRMGALVNEVREAIQTRLEDKISNLEKAVIEAKLATETIDVTLPGRPVETGCHHPLTAVVEQIEDVFIGMGYEVAEGTEVEKDYYNFEALNLPKDHPARDMQDTFYITEETLLRTHTSSVQARTMENNKEKGPIKIICPGKVYRRDDDDATHSHQFMQIEGLVIDKNIRMSDLKGTLQVFVKKMFGEDREIRLRPSFFPFTEPSVEMDISCMMCHGKGCGTCKGTGWIEILGAGMVHPNVLEMAGYDSKEYQGFAFGMGAERIAMLKYGVDDIRHFYTNDVRFLQQFKRA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_DELAS
Sequence: MAKSPANNAAQRVRKKVRKNISDGIAHVHASFNNTIITITDRQGNALSWASSGGQGFKGSRKSTPFAAQVASEVAGRAAIEQGIKNLDVEIKGPGPGRESSVRALGALGIRITSIADVTPVPHNGCRPQKRRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TOP6B_METTH
Sequence: MARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILPEIKIDLKRIGKDHYILRHQDNGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGLILEKEEVEVDGTGVCIELHFKDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWGVTADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQIVEAFKKMKFMSPPTSGLIPIGEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGIAYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGVKSLDWKRYGIRDLENAPISIFVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIFESYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: PSBH_TRIV2
Sequence: MAQRTRLGDILRPLNSEYGKVAPGWGTTPVMGVFMALFLVFLLIILQLYNKSILIQDVRVGW
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SCN2B_RAT
Sequence: MHRDAWLPRPAFSLTGLSLFFSLVPSGRSMEVTVPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK
What is the function of this protein?
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel.  The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli.  Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
What are the official names of this protein?
Sodium channel subunit beta-2.
What is the protein family that this protein belongs to?
Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RIBBA_SYNWW
Sequence: MFSSIEEVIQDIKEGKMIVLVDDEDRENEGDVIIAAEKAGPEAINFMATHAKGLICMPIIGERLDELEIHDMVTENTDNHETAFTVTVDYRGTTTGISAFERAATVKALIDSVSKPSDFRKPGHIFPLRYREGGVLRRAGHTEGSIDLTRLAGLYPAAVICEVMNEDGTMARLPQLLEFARQHNLKLASIADLIEYRRRKEKLVVRVTDAQLPTMYGDFVAVAYESLLDNKGHIALVKGEWEEDEPILVRVHSECLTGDVFGSRRCDCGEQLETAMSMIASEGKGVLLYMRQEGRGIGLLNKIKAYKLQDNGRDTVEANLELGFPADLRDYGIGAQILVDLGVRKMRLMTNNPKKIRGLEGYGLEVVERVAIEMPHKPENTRYLRTKKEKMGHLLASL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: VKT2_OXYMI
Sequence: MSSGGLLLLLGLLTLWEVLTPVSSKDRPDFCELPADTGPCRVGFPSFYYNPDEKKCLEFIYGGCEGNANNFITKEECESTCAA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor microlepidin-2.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: LAEA_PENRW
Sequence: MSYRESSGSFPAPDRTSLPKMFTNGDSRLRHLPPISSPPPPKRYKSESTPGSDAGHSRYYSHSVASDRTRSRQPSSAMDLYTLIDRDPVDKDPRRNARFTSNGSVATQASHASNASQISRSSPIIISDRKIPEKYPNHKENGRMYHGYRKGIYPLPCDEEEQDRLDIFHKLFTVARAEDGLIYAPHPPGSRILDLGCGTGIWSIEVANKFPGSFVVGVDLAPIQPTNTPKNCDFYAPFDFEAPWTMGEDSWDIIHMQMGCGSVASWPSLYRRVFQHLKPGGWFEQVEIDFRPRVEDKDGEPGRAMANWYSTLKHATEATMRPLAHSSNETIRNLQEAGFTEIDHQIVGLPMNPWHPDSHEQKVARWYNLAISESVQPMCLAPFSRVLSWTREQIDRIAFDVKQEAFDKRIKTYNLLHIYQARKPVEE
What is the function of this protein?
Methyltransferase that performs automethylation (By similarity).  No other methyl-accepting substrate has been identified yet (By similarity).  Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:18952140, PubMed:22439693).  Controls the expression of the penicillin gene cluster (PubMed:18952140, PubMed:20543063, PubMed:22439693, PubMed:23089625, PubMed:23264641).  Controls benzylpenicillin production, but is not involved in the biosynthesis of the alkaloid roquefortine C (PubMed:18952140).  Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879).  Positively controls the expression of the transcription factor atfA (PubMed:25557366).  Regulates also asexual differentiation (PubMed:18952140, PubMed:23264641).
What are the official names of this protein?
Secondary metabolism regulator laeA, Methyltransferase laeA, Velvet complex subunit laeA.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: WHIA_CORGL
Sequence: MSLTSDIKQELAQVHVAKNSVRAAEVSAILRFAGEMQAVGGKLVIEANLDSMQVGMRLQEFIQGLYNSRVDVHTVNPTVSRKTPRYLVRIIDNADEIARRTGLVTRSGHVVKGLAPSVVSGTISDAEAAWRGAFLANGSLSDPGRSSSLEVLCPGQESALALVGCARRIGIAAKTKDSRGFDRVNVRDAEAIGALLTRMGAQKTRMLWEEKRIKRESRTPANRLANFDDANLRRSARAAVAAAARVERAMKILGDDVPEHLAEAGQLRVQHRQASLEELGRLADPQMTKDAVAGRIRRLLTMADKRAEDLKIPDTNSVVTEDLLEEI
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RL17_RICAE
Sequence: MRHKIKSRKLNVTSSHRQAMLANMAVALVTHEQIKTTLPKAKELRPYIETLITKAKKADLMVRRSVLSKIKDKTAVEKLINILGIRYKDRPGGYTRIIKAGFRYGDLAPIAYIEFVDRDINAKGNIQQDANEEIKN
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TGT_CAMHC
Sequence: MKFQIDKTDGNARACTITTAHSVIKTPIFMPVGTVGAVKSLDALDLKEILDAKIILANTYHMFLRPGSKIVKEFGGLHGFTKFDRSFLTDSGGFQAFSLRTNTKNDDDGIHFKSHIDGSLHYFTPTSVLDTQYDFGSDIMMILDDLVALPADPKRVKLSIERTIKWAKKAINYHLQKRESGVGLNQNIFGIIQGGTDENARKFCAQSLCELPFDGLAIGGLSVGETNREMYDTVEAVMPYIDSARPRYLMGVGTPEDIVENVERGVDMFDCVMPTRNARNGTLFTSFGKINIKSARFIHDDTPIDPCCDCYTCKNYSRGYLNHLYRAREITFYRLASLHNLHYYLHLVSDIRTAILEGKFLEFKKDFYSKRS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CSPL1_EUTHA
Sequence: MSYLGVGLSPVNVAGTKMKLMDRKVRLTELILRCSVCALALVAAILIATDTQVKEIFTIQKKAKYTDMKALVFLVVVNGIAAAYSLLHMVRCVVGMMKGSVLFSKPLAWAIFSGDQAIAYLTVAGVAAAAQSAAFAKLGEPELQWMKICTIYGKFCNQVGEGIATALLASIGMVLISSISAFALFRLYGGNKAQQGSRW
What are the official names of this protein?
CASP-like protein 2B1, ThCASPL2B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHRS9_MOUSE
Sequence: MLFWLLALLFLCAFLWNYKGQLKIADIADKYVFITGCDTGFGNLAARTFDKKGFRVIAACLTESGSAALKAKTSERLHTVLLDVTDPENVKKTAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTELADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSSVNLDLSLVVGCMDHALTSLFPKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPKAV
What is the function of this protein?
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone.  Also plays a role in the biosynthesis of retinoic acid.  Can utilize both NADH and NADPH.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 9, 3-alpha hydroxysteroid dehydrogenase, 3-alpha-HSD, Retinol dehydrogenase, Short-chain dehydrogenase/reductase retSDR8.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome membrane. Endoplasmic reticulum membrane.
Protein: DER_MYCUA
Sequence: MTQDGTWSDESDWELDDADLADLAEAAPAPVLAIVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVSYDALWNGRRFVVQDTGGWEPDAKGLQQLVAEQASVAMRTADAVVLVVDATVGATTADEAAARILLRSGKPVFLAANKVDSDKAEADAATLWSMGLGEPHAISAMHGRGVANLLDTVLKKLPEVAESVSAGGGPRRVALVGKPNVGKSSLLNKLAGDERSVVHDVAGTTVDPVDSLIELGGKVWRFVDTAGLRRKVGQASGHEFYASVRTRGAIDAAEVVVLLIDASQPLTEQDLRVLSMVIEAGRAVVLAYNKWDLVDEDRRDLLDREIDRELVQIRWAQRVNISAKTGRAVQKLVPAMETALASWDTRIPTGPLNSWIKEVVAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFEGSPIRINVRVREKRGAKRPGRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PRP_PHAVU
Sequence: NYDKPPVEKPPVYKPPVEKPPVYKP
What are the official names of this protein?
Repetitive proline-rich cell wall protein.
What is the protein family that this protein belongs to?
Belongs to the plant proline-rich protein superfamily. ENOD12 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RS10_XANAC
Sequence: MSEQKIRIRLKAFDHRLIDRSASEIVETAKRTGAQVRGPIPLPTKIERYTILVSPHADKDARDQYETRTHKRVLDIVDPNDKTVDALMKLELAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.