PharMolix/UniProtQA huggingface dataset:
Protein: HPTS_STAAB
Sequence: MTAYKPYRHQLRRSLFASTIFPVFLVIIIGLVSFYAIYIWIEHRTIHQHVNESQSSLHHIEKQIQTFITQHNNSFQELDLTNHHDVTATKRELLKLIHQQPATLYYELSGPNQFITNNYEHLNTKNMYLFSTHQLKFKNSTYMLKIYMANTPRLSEIKKDSRQFALIVDRYDNILYANDDRFTIGEKYRPQQFGFMNESVKLNHANHRLIIYKDIHENIEDGITLLIVMAVVLVLLVIFGFISADNMAKRQTKDIETIIQKIYYAKNRHLGTYTPLKNNSELEEINNYIYDLFESNEQLIHSIEHTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLITLSPKLAQTVVQQLSQMLRYSLRTNSHTVELNEELNYIEQYVAIQNIRFDDMIKLHIESSEEARHQTIGKMMLQPLIENAIKHGRDTESLDITIRLTLARQNLHVLVCDNGIGMSSSRLQYVRQSLNNDVFDTKHLGLNHLHNKAMIQYGSHARLHIFSKRNLGTLICYKIPLSRGNVDV
What is the function of this protein?
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources.  May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS.  In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
What are the official names of this protein?
Sensor protein kinase HptS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS14_NEOSM
Sequence: MAKKALVVKDERKRALACRSREKRSAVRNMRNDKTISLKERVAIQAKLNSLPRNSSPARSKNRCSITGRPRGYYRKFGISRIQLRVLANWGKLPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: NDHI_EUCGG
Sequence: MFPMVTGFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETGIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVINDYTIRTISNSPQIIIK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GLYA_LIGS1
Sequence: MDFKKLDPELWQAIANEEQRQQNNIELIASENIVSKNVLDAQGSVLTNKYAEGYPGRRYYGGCQFIDVVENLAIDRAKQLFGAKYVNVQPHSGSQANAAAYMSLVEPGDTIMGMDLAAGGHLTHGSPVNFSGKTYNFVSYGVDKKTEMLDYDEIARLAREHQPKLIVAGASAYSRIIDFSKFREIADEVGAKLMVDMAHIAGLVAVGLHPNPVPYADITTTTTHKTLRGPRGGMILTNDENLAKKINSNVFPGTQGGPLEHVIAGKAAAFGEALTPEFKEYGEQIIRNTQEMALCFADNEKARLVSNGSDNHLLLLDVRNFGLNGKEAEKLLDQVNITVNKNSIPFETLSPFKTSGIRIGTPAITSRGFNEEDSYQVAKLILTVLANKDDEQVLADVKRQVKELTDAHPIYAEYSIR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_ECOLC
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: SYEM_MOUSE
Sequence: MAAPLKRLLLAEPHVVALGHRVGRREASLGPDPGAPVRVRFAPSPTGFLHLGGLRTALYNYIFAKKHQGSFILRLEDTDQSRLVPGAAESIEDMLEWAGIPPDESPRRGGPAGPYCQSQRLALYAQATEALLRSGAAYPCFCLPQRLELLKKEALRSRQTPRYDNRCRNLSQAQVAQKLAVDPKPAIRFRLEEAVPAFQDLVYGWTQHEVASVEGDPVILKSDGFPTYHLACVVDDHHMSISHVLRGSEWLVSTSKHLLLYQALGWQPPRFAHLPLLLNRDGSKLSKRQGDIFLEHFAATGFLPEALLDIITNCGSGFAENQMGRTLPELITQFDLTRITCHSALLDLEKLPEFNRLHLRRLVSSETQRPQLVEKLQGLVKEAFGSELQNKDVLDPAYMERILLLRQGHISRLQDLVSPVYSYLWTRPAVHRSELGASSENVDVIAKRLLGLLERPGLSLTQDVLNRELKKLSEGLEGAKHSSVMKLLRMALSGQLQGPPVAEMMVSLGPKEVRERIQKVLSS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Probable glutamate--tRNA ligase, mitochondrial, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: TBX6L_DANRE
Sequence: MNHLANNYGYYPQDCRTQYSRMNSAEAELTSLPVHVSLQDRELWDKFSSIGTEMLITKSGRRMFPSCKVTVTGLNPKVKYVVIMDMVPFDNHKYKWNKDCWEVNGSSDPHLPNRFFIHPDSPAPGQKWMQYPISFHKLKLTNNTLNSNGLVVLHSMHKYQPRLHIVQSPDPCTPHNPGAYLRFTFPEAAFIAVTAYQNQEITKLKIDNNPFAKGFRDNGLNRKRFRDKGTQEMQDTDRQVKLDLTANECAAGMSQMVEDVDVSVSSSVDCRDTQNSSSVSLNPFISAFTNPSSAGGAAAHQTHTLLSLSNRHFSSPRESNLNSVCAALPVSQLSTGHTSFSRLNPQETHHNSRPKIQLQPPHPSLQCHDLDVRLPLPPKLSRVQLSESALRNLEMSPLSDCANPRPLTNILNRSCFRASTPSGKLLPNPPQPEQFLRGSEREIYPAVQEYTDQQFTLNSQTEHRPHMRPLTEY
What is the function of this protein?
Probable transcriptional regulator involved in developmental processes.
What are the official names of this protein?
T-box transcription factor TBX6L, T-box protein 6L, T-box transcription factor TBX6, T-box protein 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y085_CHLTR
Sequence: MFSLRSLVDYLRSQHELIDIHVPVDPHLEIAEIHRRVVEREGPALLFHQVKGSPFPVLTNLFGTRRRVDLLFPDLSSDLFEQIIHLLSSPPSFSSLWKHRSLFKRGISALGMRKRHLRPSPFLYQDAPNLSQLPMLTSWPEDGGPFLTLPLVYTQSPENGVPNLGMYRMQRFDKETLGLHFQIQKGGGAHFFEAEQKKQNLPVTVFLSGNPFLILSAIAPLPENVPELLFCSFLQNKKLSFVEKHPQSGHPLLCDSEFILTGEAVAGERRPEGPFGDHFGYYSLTHDFPIFKCNCLYHKKDAIYPATVVGKPFQEDFFLGNKLQELLSPLFPLIMPGVQDLKSYGEAGFHALAAAIVKERYWKEALRSALRILGEGQLSLTKFLWITDQSVDLENFPSLLECVLERMNFDRDLLILSETANDTLDYTGSGFNKGSKGIFLGVGAPIRSLPRRYRGPSLPGISQIGVFCRGCLVLETSLQQLDIPALLKEPHLADWPLVILVEDLSSALSSTKEFIWRTFTRSSPATDLHIPVSQITNHKVSYTPPMILNALMKPPYPKEVEADEATQNLVSSRWHSYFP
What are the official names of this protein?
Uncharacterized protein CT_085.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
Protein: CMOB_RUTMC
Sequence: MLSDFYKYATSTQLDLICTQLINLSTHVFNTNNGNIPKWEQAIKQIKTQNTGSLDFITPYLNISAHHINNFTLEKSLKQLIPWRKGPYQIGDLQLDSEWRGDMKWHRLIPHIKPLKDKVVLDVGSGNGYFTYLMAISGAKIALGIEPFLLFNYQFQAIRTLINNLPNVFVLPLSLDKIPKKPLFDTVFSMGVLYHQKDYELHLNQLKDVMKPSGELILETLIIDLEKVKKIIPKGRYAKMRNVYCLPSKNTLRTWLEDAEFKNIKLLDVTKTTSKEQRATHWIGNNTQSLKNFLDPNNRDLTIEGFPAPKRAIFICQK
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: E1166_IXORI
Sequence: MEVKIFTLLQIALFIALGIHLVVAGPETKEDKKSDVYELFTVEYCGTNCTLLTNGRWTACTGKKGTCRCYHESGEKVGLCLSTEYTDFSEYPNPKSSEIDAAAPLPRETH
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2 and CXCL8.
What are the official names of this protein?
Evasin P1166.
What are the subcellular locations of this protein?
Secreted.
Protein: HS3SB_MOUSE
Sequence: MGQRLSGGRSCLDVPGRFLPQPPPPPPPVRRKLALLFAMLCIWLYMFLYSCAGSCTAAPGLLLLGSGSRATHAQPALVTAPNETSPKMPFRAPPANSLAAGKDKTVGAGSQEEQSPEAPDSPSPISSFFSGAGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLKGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIGLYAKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLKRIITDKHFYFNQTKGFPCLKKAEGSGKPHCLGKTKGRAHPTIAREVLRQLRDFYRPFNRKFYQMTGRDFGWD
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate.  Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2.  Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).
What are the official names of this protein?
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, 3-OST-3B, Heparan sulfate 3-O-sulfotransferase 3B1, m3-OST-3B.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: TRMD_CLOTE
Sequence: MAFRIDILTLFPDMFNIFNHSIMGKALEKDIININTINIRDFTEDKHKKVDDYPYGGGAGMVMSLQPIVDSLKRVKESNRGKVIFLGPRGKTFSHEMAKELSKEEELIFLCGHYEGIDERCYDYIDLEISLGDFILTGGEMACIPIVDSICRLIPGVLGKNESFMEESFYEGLLEYPHYTRPENFKGKEVPKILLSGHHENIRKWRKSKSLKITKKRRPDLFKKYNLTKEDEKLLSSEE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROQ_ERWT9
Sequence: MENQPKLNSTKEVIAFLAERFPLCFSAEGEARPLKIGIFQDLVERVQGEMSLSKTQLRSALRLYTSSWRYLYGIKAGAIRVDLDGNACGQLDEQHVEHARKQLEEAKARVQAQREQHQAKKREAGEATAPRRPRKPARKPAAEGEQSRSVSGKPSRPQAARPASAPRAESRVEQRKPVTDTTALQVGQSIKVTAGKNAMDATILEISKDGVRVQLASGLAMIVRAEHLQF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_ECO24
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YG31B_YEAST
Sequence: MSFMDQIPGGGNYPKLPVECLPNFPIQPSLTFRGRNDSHKLKNFISEIMLNMSMISWPNDASRIVYCRRHLLNPAAQWANDFVQEQGILEITFDTFIQGLYQHFYKPPDINKIFNAITQLSEAKLGIERLNQRFRKIWDRMPPDFMTEKAAIMTYTRLLTKETYNIVRMHKPETLKDAMEEAYQTTALTERFFPGFELDADGDTIIGATTHLQEEYDSDYDSEDNLTQNGYVHTVRTRRSYNKPMSNHRNRRNNNPSREECIKNRLCFYCKKEGHRLNECRARKAVLTDLELESKDQQTPFIKTLPIVHYIAIPEMDNTAEKTIKIQNTKVKTLFDSGSPTSFIRRDIVELLKYEIYETPPLRFRGFVATKSAVTSEAVTIDLKINDLHITLAAYILDNMDYQLLIGNPILRRYPKILHTVLNTRESPDSLKPKTYRSETVNNVRTYSAGNRGNPRNIKLSFAPTILEATDPKSAGNRGDSRTKTLSLATTTPAAIDPLTTLDNPGSTQSTFAQFPIPEEASILEEDGKYSNVVSTIQSVEPNATDHSNKDTFCTLPVWLQQKYREIIRNDLPPRPADINNIPVKHDIEIKPGARLPRLQPYHVTEKNEQEINKIVQKLLDNKFIVPSKSPCSSPVVLVPKKDGTFRLCVDYRTLNKATISDPFPLPRIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYTVMPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDTVLERLKNENLIVKKKKCKFASEETEFLGYSIGIQKIAPLQHKCAAIRDFPTPKTVKQAQRFLGMINYYRRFIPNCSKIAQPIQLFICDKSQWTEKQDKAIDKLKDALCNSPVLVPFNNKANYRLTTDASKDGIGAVLEEVDNKNKLVGVVGYFSKSLESAQKNYPAGELELLGIIKALHHFRYMLHGKHFTLRTDHISLLSLQNKNEPARRVQRWLDDLATYDFTLEYLAGPKNVVADAISRAVYTITPETSRPIDTESWKSYYKSDPLCSAVLIHMKELTQHNVTPEDMSAFRSYQKKLELSETFRKNYSLEDEMIYYQDRLVVPIKQQNAVMRLYHDHTLFGGHFGVTVTLAKISPIYYWPKLQHSIIQYIRTCVQCQLIKSHRPRLHGLLQPLPIAEGRWLDISMDFVTGLPPTSNNLNMILVVVDRFSKRAHFIATRKTLDATQLIDLLFRYIFSYHGFPRTITSDRDVRMTADKYQELTKRLGIKSTMSSANHPQTDGQSERTIQTLNRLLRAYASTNIQNWHVYLPQIEFVYNSTPTRTLGKSPFEIDLGYLPNTPAIKSDDEVNARSFTAVELAKHLKALTIQTKEQLEHAQIEMETNNNQRRKPLLLNIGDHVLVHRDAYFKKGAYMKVQQIYVGPFRVVKKINDNAYELDLNSHKKKHRVINVQFLKKFVYRPDAYPKNKPISSTERIKRAHEVTALIGIDTTHKTYLCHMQDVDPTLSVEYSEAEFCQIPERTRRSILANFRQLYETQDNPEREEDVVSQNEICQYDNTSP
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
What are the official names of this protein?
Transposon Ty3-G Gag-Pol polyprotein, Gag3-Pol3, Transposon Ty3-1 TYA-TYB polyprotein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MSBA_YERPS
Sequence: MMNDKDLSTWQTFRRLWPTISPYKAGLIVAAIALILNAASDTFMLSLLKPLLDDGFGNSNSSILKWMPLAVIGLMVVRGVTGFVSSYCISWVSGKVVMHIRRRLFSHMMGMPVSFFDQQSTGTLLSRITYDSEQVAASSSSALVTVVREGASIIGLFIMMFYYSWQLSLILIVIAPIVSISIRLVSKRFRNISKNMQNTMGEVTTSAEQMLKGHKEVLIFGGQKVETERFDAVSNRMRQQGMKLVSASSISDPIIQLIASFALALVLYAASFPSVMETLTAGTITVVFSAMIALMRPLKSLTNVNTQFQRGMAACQTLFSILDMEQEKDEGKLEVERAKGDIEFRHVTFYYPGKDTPALNDINIHLEAGKTVALVGRSGSGKSTIANLLTRFYDVSEGSILLDGHDLRDYRLGALRNQVALVSQNVHLFNDTVANNIAYARNEQYSRAEIEEAARMAYAMDFINKMEHGLDTVIGENGIMLSGGQRQRIAIARALLRNCPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVIEDGRIVERGVHAELLVQQGVYAQLNRMQFGQ
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: M2_I89A7
Sequence: MSLLTEVETPTRNGWECKCDDSSDPLVIAASIIGILHLILWILDRLSFKCIYRRLKYGLKRGPSTEGVPESMREEYQQEQQNAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: NLPI_ECO57
Sequence: MKPFLRWCFVATALTLAGCSNTSWRKSEVLAVPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQHFEKSDKEQWGWNIVEFYLGNISEQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ
What is the function of this protein?
May be involved in cell division.  May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity).
What are the official names of this protein?
Lipoprotein NlpI.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: UVRC_MYCSJ
Sequence: MPDPSTYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLNSYFADLSGLAPRTRQMVMTAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLNEEFPRLKVYRGPRKKGVRYFGPYSHAWAIRETVDLLTRVFPARTCSAGVFKRHNQIDRPCLLGYIDKCSAPCVGRVSAEQHRQIVLDFCDFLAGKTDRLVRDLERKMTAAAEDLDFERAARLRDDIGALRRALEKQTVVFGDGTDADVVAFADDDLEAAVQVFHVRGGRVRGQRGWIVEKSGEPGESGEGQLVEQFLTQFYGDQAELGSAGDNAGDSGQDEATNPVPRQVLVPCLPDNADELTEWLSQLRGSRVALRVPQRGDKKALFETVQRNAKEALAQHKLKRAGDFTARTAALQSIQDTLGLADAPLRIECIDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIREAAGDGRSDDVASIAEVTRRRFYRHLHDTQHPTELSAEGKSRKFAYPPNLFVVDGGAPQVNAAQAVLDELGISDVAVIGLAKRLEEVWVPSGSDLGPEPIILPRNSEGLYLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVRGLGEHRRKALVTHFGSVARLKEASVEEITAVPGIGVTTARAVLEALGVPQAAPADSGTAAAVIDDDQRRVTG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_RUTMC
Sequence: MNKLRNQTLALASILQTTTLVDQLASTGACDANSNQASLKSIITSSTKLEEVFNSKQDLLVGIAALKVVLGNKTKRIQQVILYALALINLEKKLMKNQTLLNQITLEIDLIKNQEFFEISHANSVARLAQLYKSTLGGLNPRIMINGEQIYLSNKHTTNHIRALLLAGIRAVSLWKSQGGKTWHLLFNKKKILNLISSLEGLNK
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: APEB_MYCTU
Sequence: MAATAHGLCEFIDASPSPFHVCATVAGRLLGAGYRELREADRWPDKPGRYFTVRAGSLVAWNAEQSGHTQVPFRIVGAHTDSPNLRVKQHPDRLVAGWHVVALQPYGGVWLHSWLDRDLGISGRLSVRDGTGVSHRLVLIDDPILRVPQLAIHLAEDRKSLTLDPQRHINAVWGVGERVESFVGYVAQRAGVAAADVLAADLMTHDLTPSALIGASVNGTASLLSAPRLDNQASCYAGMEALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQSDLLSSVLERIVLAAGGTREDFLRRLTTSMLASADMAHATHPNYPDRHEPSHPIEVNAGPVLKVHPNLRYATDGRTAAAFALACQRAGVPMQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQLAMHSARELMGAHDVAAYSAALQAFLSAELSEA
What are the official names of this protein?
Probable M18 family aminopeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M18 family.
Protein: DEF44_ARATH
Sequence: MAITKTSVTLLLLIIMAASLSNFSVLASEIKPTGRVDNQCKEMCSATFGDGKCAADCRKAGFSSGRCLTSSPFGNKCCCT
What are the official names of this protein?
Defensin-like protein 44.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSB_BUCBP
Sequence: MASRGINKVILIGYLGQDPDVRYMQNGSAVTNITLATSETWKDKNNGEIKEKTEWHRIVFFNKLAEIAGEYLKKGSQVYIEGSLQTRKWKDQNGIERYITEIIVSVGGTMQMLGSRNSSSLTASSGLSKNNDNLSKQLLSEKKQESFNDSKLQNNNLDFDDEDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: EF1A_THEPD
Sequence: MSEKKPHLNLVVIGHIDHGKSTLMGRLLYEIGAVDPRLIQQYEEEAKKMGRETWKYAWVLDKLKEEREKGITIDLGFYKFETKKYFFTLIDAPGHRDFVKNMITGASQADVALLVVSAKEGEFEAGISPAGQTREHVFLAKTMGVDQLVVAINKMDTVNYSKERYEEIKNQLIRLLRMVGYKVDEIPFIPTSAWEGVNVSKRTPEKTPWYDGPCLYEAFDFFKEPPRPIDKPLRIPIQDVYSIKGVGTVPVGRVETGVLKVGDKIIINPPKAVGEVKSIETHHTPLQEAIPGDNIGFNVKGVEKSQLRRGDVAGHTTNPPTVAEEFTGRIFVLYHPTAIAAGYTPVLHIHTATVPVTFEELLQKLDPRTGSVAEEKPQYIKQGDSAIVRFKPRKPVVVEKYSEFPPLGRFAIRDSGRTIAAGVVIDVKKAEGY
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_YERPP
Sequence: MSGSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQQHAKGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADLEDRERFLNARDTMNALLDNRIVPVINENDAVATAEIKVGDNDNLSALAAILASADKLLLLTDQAGLYTADPRNNPEAELIREVHGIDDVLRGMAGDSVSGLGTGGMATKLQAADVACRAGIDVVIAAGSQVGVIADVIDGTPVGTRFHSLETPLENRKRWIFGAPPAGEITVDDGAVFAIMERGSSLLPKGIRSVKGDFSRGEVIRIRNLNGRDLAHGVSRYNSDALRMLAGHHSQQISEILGYEYGPVAVHRDDMIVS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_RHOPS
Sequence: MTTPIIVTGTDTGVGKTVFSAALAGALEATYWKPVQAGLDEETDRLAVLRLSGLPETRLLAEAYRLTTPASPHLAAEIDGVAIDPEALVLPDTQGPLVVEGAGGLLVPLTRHVTYIDVFATWRAPVVLCARTTLGTINHTLLSIEALRARAIPLLGIAFIGDENAESERIIVELGRARRLGRLPHLAQLTTDALRAAFARNFNTADFLKETA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.