PharMolix/UniProtQA huggingface dataset:
Protein: PUR7_BACAA
Sequence: MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGAIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RDRP_SCV20
Sequence: MKEPVDCRLSTPAGFSGTVPPPGRTKAARPGTIPVRRSRGSASALPGKIYGWSRRQRDRFAMLLSSFDAALAAYSGVVVSRGTRSLPPSLRLFRAMTRKWLSVTARGNGVEFAIASAKEFSAACRAGWISGTVPDHFFMKWLPEPVRRKSGLWAQLSFIGRSLPEGGDRHEIEALANHKAALSSSFEVPADVLTSLRNYSEDWARRHLAADPDPSLLCEPCTGNSATFERTRREGGFAQSITDLVSSSPTDNLPPLESMPFGPTQGQALPVHVLEVSLSRYHNGSDPKGRVSVVRERGHKVRVVSAMETHELVLGHAARRRLFKGLRRERRLRDTLKGDFEATTKAFVGCAGTVISSDMKSASDLIPLSVASAIVDGLEASGRLLPVEIAGLRACTGPQHLVYPDGSEITTRRGILMGLPTTWAILNLMHLWCWDSADRQYRLEGHPFRATVRSDCRVCGDDLIGVGPDSLLRSYDRNLGLVGMILSPGKHFRSNRRGVFLERLLEFQTRKTVYEHAVIYRKVGHRRVPVDRSHIPVVTRVTVLNTIPLKGLVRASVLGRDDPPVWWAAAVAESSLLSDYPRKKIFAAARTLRPGLSRQFRRLGIPPFLPRELGGAGLVGPSDRVDAPAFHRKAISSLVWGSDATAAYSFIRMWQGFEGHPWKTAASQETDTWFADYKVTRPGKMYPDRYGFLDGESLRTKSTMLNSAVYETFLGPDPDATHYPSLRIVASRLAKVRKDLVNRWPSVKPVGKDLGTILEAFEESKLCTLWVTPYDASGYFDDSLLLMDESVYQRRFRQLVIAGLMREGRMGDLLFPNWLPPSTVVSGFP
What is the function of this protein?
RNA-directed RNA polymerase that replicates the viral (+) and (-) genome.
What are the official names of this protein?
RNA-directed RNA polymerase, p91.
What are the subcellular locations of this protein?
Host cytoplasm. Note=The virus has no extracellular transmission pathway. It exists as a ribonucleoprotein viral particle in the host cytoplasm and can be transmitted through mating or cytoplasmic mixing (cytoduction).
Protein: RADA_PYRAB
Sequence: MGKKSSDPAVVEINDVDELELEVGEEVTSKKKKKEKEIRTIEDLPGVGPATAEKLREAGFDTLEAIAVASPIELKEVAGISEGAALKIIQAARKAANLGTFMRADEYLKKRESIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVIWIDTENTFRPERIREIAKNRGLDPDEVLKHIYVARAFNSNHQMLLVQQAEDKIKELLNTDKPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYEIAVFVTNQVQARPDAFFGDPTRPIGGHILAHSATLRVYLRKGKGGKRVARLIDAPHLPEGEAVFRITEKGIED
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.
Protein: MPU12_ARATH
Sequence: MDYLGIDMSCAIGSLRNGDFPEKDCLLPLISKLLGYCLVAASITVKLPQIMKIVQHKSVRGLSVVAFELEVVGYTISLAYCLHKGLPFSAFGEMAFLLIQALILVACIYYYSQPVPVTTWIRPLLYCAVAPTVLAGQINPTLFEALYASQHAIFLFARLPQIWKNFKNKSTGELSFLTFFMNFAGSIVRVFTSLQEKAPISILTGFALGVVTNGSILTQILLYSKPAAAKEKKAN
What is the function of this protein?
Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.
What are the official names of this protein?
Mannose-P-dolichol utilization defect 1 protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the MPDU1 (TC 2.A.43.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRUD_HELPG
Sequence: MNLNFMPLLHAYNHASIDFHFNSSARDFCVHEVPLYEFSNTGEHAVIQVRKSGLSTLEMLHIFSQILGVKIAELGYAGLKDKNALTTQFISLPKKYAPLLEKNTSNFQERNLKVLSLNYHHNKIKLGHLKGNRFFMRFKKMTPLNAQKTKQVLEQIAQFGMPNYFGSQRFGKFNDNHKEGLKILQNKTKFAHQKLNAFLISSYQSYLFNSLLSKRLEISKIISDFSVKENLEFFKQKNLSVNSNALKALKNQAHPFKILEGDVMCHYPYGKFFDALKLEKESERFLKKEAVPTGLLDGKKALYAKNLSLEIEKEFQHNLLSSHAKTLGSRRFFWVFAENVTSQYIKEKAQFELGFYLPKGSYASALLKEIKHEKGENNDEF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: RL30_STAAR
Sequence: MAKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVKHLVTVEEK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ATCL_MYCPN
Sequence: MNKWTGLSAAAVLESRAQHGANLIPTKKLTPFWLLFLEQFKSLVVILLLVATILSLVVAIISGVNANWLFDHNLVIEWTQPFVILITVLANSLIGSIQEFKAQKSAHTLKSLTQPFTRVFREEGLVSLPVGEVVVGDIIFLEAGDIIPADGKVLQANHLRCMESFLTGESVPVDKSVVNTGGKGLLEQTNLLFSGAQVVFGSGVFEVTAVGLNTQVGQIVKTVDSSATKLSPLQQKLEKVGKWFSWFGLGLFVVVFLVQLGLLGFHNFSANWSIALIGAIALVVAIIPEGLVTFINVIFALSVQKLTKQKAIIKYLAAIETLGGVQIICTDKTGTLTQNKMKVVDYFCFSNTTQTDLARALCLCNNATVNTNGDSTGDPTEIALLQWLDRDGLELNHYTRVYEKAFDSNRKLMSVVVQKDNRFIVIVKGAHDVLLPLCKGLDSNQIKPLIDERASNGLRNLAVGLKVLYCFDPENTQTVNELESELDFLGSVSLQDPPRIESKAAIMACHQANITPIMITGDHLKTATAIAKELGILTDERQAILGVDLDPAKIMEYRVFARVTPQQKLEIVNAWKQAGYTVAVTGDGVNDAPALVTSDVGCCMGQTGVDIAKDAADVIISDDNFATIVNGIEQGRKTFLTCKRVLFNLFLTSIAGTIVVLLGLFVLGEVFREQLSKANHNFQVFTPTQLLIINLFVHGFPAVALAIQPVQEKLMLKPFSTKNLFYNRGGFDLIWQSLLLSFLTLLFYSLGMVYAINDPELGKSGDLINRAGATCGFMVLGGSAALNSLNLMVDRPLVATNPKHYGIVWLGALSSIFVFLLIIFINPLGLVFSTLKDLTAHPVLIGYSFGGVLLYMTINEVVKLIRLSYGSV
What is the function of this protein?
Could mediate calcium influx.
What are the official names of this protein?
Probable cation-transporting P-type ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type II subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNAR1_RAT
Sequence: MEANQEASLFLVKILEELDSKQNTVSYQDLCKSLCAQFDLSQLAKLRSVLFYTACLDPNFPATLFKDKMKCSVNNQQSKKIMVAADIVTIFNLIQMNGGTAKEKLPTSCHKVRKEEASFESCRSDAEVCSPTVCEPLNCELSERPFSRGYPTRQSSKCRKMDCKECPQFVPASEPNFLLGVSKEVKNRAASLDRLQALSPYSVASPQPCEMQRTYFPMNIENESISDQDSLPIGQGIKETFISSEEPFMVQSCVQKRNIFKEDFHNLMTVSPSLVGTTNKAEEDHGEPRSQKELHKPPFFNHSFEMPYHSQYLNPVYSPIPDKRRAKHESLDDLQASTYFGPTPVMGTQDTRRCPGRPSKQTPWPAKSWSLNTEEVPDFERSFFNRNPSEEKLRYPNSGNQTPNFSGPDRHPVYLVPKDQQKVLPAGYAVKPNGLKSKEIPSPVDLEKHEAVKKFKDKSISCTSGQHSSDTSSVGTQTEQHVLDPPKCKDLCSAGQAKYSDRHAMKHSDDDSEIVSDDISDIFRFLDDMSISGSTGVIQSSCYNSTGSLSQLHKSDCDSSPEHNLAKITNGVSGSKGDKCNRPENVHHSEEELKSSVCKLVLRIGEIERKLESLAGVREEISQVLGKLNKLDQKIQQPEKVNVQIDLNSLTSEAPSDDSASPRVFHAHSGSHGPKLENSPDWCCSDVSGSNSESLRVKALKKSLFTRPSSRSLTEENSATESKIASISNSPRDWRTITYTNRMSLNEEEIKDAGPANNKDWHRKSKEADRQYDIPPQHRLPKQPKDGFLVEQVFSPHPYPSSLKAHMKSNPLYTDMRLTELAEVKRGQPSWNIEEYARNTGDKGKLTALDLQTQESLNPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKVCKIAALITAAACTVILVIVVPICTMKS
What is the function of this protein?
Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879).  Negatively regulates angiogenesis (By similarity).  Negatively regulates cell growth (By similarity).  Negatively regulates neurite outgrowth in hippocampal neurons (PubMed:30080879).
What are the official names of this protein?
Major intrinsically disordered Notch2-binding receptor 1, Membrane integral NOTCH2-associated receptor 1, Ubiquitination and mTOR signaling protein.
What is the protein family that this protein belongs to?
Belongs to the MINAR family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein.
Protein: MTNA_CANDC
Sequence: MSTTTRTLQAIKFDRNNIKLEILDQLLLPYSTTYIPITSIEDAFKAIKLMQVRGAPAIAIVGAFSVVVEVSNYLKQSDSNRKTIENLNDSLDYLITSRPTAVNLANALNDIKQLLQEFNDTDIINEKIYQQIYDYAIALYDEDLANNKKIGENGLKYIINTLTEQNFKGPFSIMTICNTGSLATSGHGTALGIIRSTYQALQKNNSKEEFWLDHIYPCETRPYNQGAKLTTYELDYEQIPFTLICDNMVSSLINTLSDDDNKKPIKTNQISPVKFIIVGADRIVENGDTANKIGTFQLSTIANFFNNNKFIQQQSKSNTTKTTINKEIKFIVAAPKTTIDLNTKTGDDIVIEERPANELTTLVGPLLNEAGDVGEKLTVGIATPGISVWNPAFDVTPHELIDSIVTEDPHVFTKDENGEFNLIK
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CHLI_OLILU
Sequence: MTEEKKINPPIFPFTAIVGQEEMKLALQLNVIDPKIGGVMIMGDRGTGKSTTIRAIADLLPEIEVVKDNQFNTAPSEDLNEEIVKIKTPMIDLPLGATEDRVCGTIDIEKALTDGVKAFEPGLLAKANRGILYVDEVNLLDDHLVDILLDSAASGLNTVEREGISIRHAARFVLVGSGNPEEGELRPQLLDRFGMHAVIKTVKDPKLRVRVVEERTLFDLNPEEWINKYREQQEALKTRIIAAQNLISSVTISDDFKLKISQVCSELDVDGLRGDIVTNRAAKAYAAFNNRTEVEIGDIEKVITLCLRHRLRKDPLETIDSGDKVQKLFEEIFD
What is the function of this protein?
Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
What are the official names of this protein?
Magnesium-chelatase subunit ChlI, Mg-protoporphyrin IX chelatase.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ENV_EIAVW
Sequence: MVSIAFYGGIPGGISTPITQQSEKSKYEENTMFQPYCYNNDSKNSMAESKEARDQEMNLKEESKEEKRRNDWWKIGMFLLCLAGTTGGILWWYEGLPQQHYIGLVAIGGRLNGSGQSNAIECWGSFPGCRPFQNYFSYETNRSMHMDNNTATLLEAYHREITFIYKSSCTDSDHCQEYQCKKVNLNSSDSSNSVRVEDVTNTAEYWGFKWLECNQTENFKTILVPENEMVNINDTDTWIPKGCNETWARVKRCPIDILYGIHPIRLCVQPPFFLVQEKGIADTSRIGNCGPTIFLGVLEDNKGVVRGDYTACNVSRLNINRKDYTGIYQVPIFYTCTFTNITSCNNEPIISVIMYETNQVQYLLCNNNNSNNYNCVVQSFGVIGQAHLELPRPNKRIRNQSFNQYNCSINNKTELETWKLVKTSGITPLPISSEANTGLIRHKRDFGISAIVAAIVAATAIAASATMSYVALTEVNKIMEVQNHTFEVENSTLNGMDLIERQIKILYAMILQTHADVQLLKERQQVEETFNLIGCIERTHVFCHTGHPWNMSWGHLNESTQWDDWVSKMEDLNQEILTTLHGARNNLAQSMITFNTPDSIAQFGKDLWSHIGNWIPGLGASIIKYIVMFLLIYLLLTSSPKILRALWKVTSGAGSSGSRYLKKKFHHKHASREDTWDQAQHNIHLAGVTGGSGDKYYKQKYSRNDWNGESEEYNRRPKSWVKSIEAFGESYISEKTKGEISQPGAAINEHKNGSGGNNPHQGSLDLEIRSEGGNIYDCCIKAQEGTLAIPCCGFPLWLFWGLVIIVGRIAGYGLRGLAVIIRICTRGLNLIFEIIRKMLDYIGRALNPGTSHVSMPQYV
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: SSRP_RHOPT
Sequence: MAEKNERAIKVVAENRKARFNYAIDDTIEVGIALTGTEVKSIRNGKTTIAESYADARGSEIWLINANIPEYLQANRFNHEPKRPRKLLLHRKQINKLIGAVEREGMTLIPLKLYFNERGRAKLQLALAKGKKLHDKRETEKKRDWSREKGRLLRSRG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CRYL1_MOUSE
Sequence: MASPAAGGVVIVGSGLIGRSWAMLFASGGFKVKLYDIEQQQITDALENIRKEMKSLEQSGSLKGSLSAERQLSLISGCGNLAEAVEGAVHIQECVPENLELKKKIFAQLDRIVDDRVILSSSSSCLLPSKLFSGLAHVKQCIVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKKIGQSPVRVLKEIDGFVLNRLQYAVISEAWRLVEEEIVSPSDLDLVMSDGLGMRYAFIGPLETMHLNAEGVISYCERYSEGMKHVLSTFGPVPEFSGATVERVSEDMCMKVPDDPEHLAARRQWRDDCLMKLSILKYQMQPK
What is the function of this protein?
Has high L-gulonate 3-dehydrogenase activity.  It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
What are the official names of this protein?
Lambda-crystallin homolog, L-gulonate 3-dehydrogenase, Gul3DH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_SYNR3
Sequence: MKGIRLCGSGAAVPRLRISNDDLSGRVETSDEWIRTRTGIAARRVADESESLTSLAAAAGKQALERAGWDASSVDLILLATSSPDDLFGSAPKVQALIGAGSAVAFDLTAACSGFLFSLVTAAQYLRTGAMTRALVIGADQLSRWVDWDDRRSCVLFGDGAGAVAIEACPAENDGLLGFRLNSDGARGDCLTLAQTSERAELLPGMSHQRGGYAPIGMNGQEVYKFAVREVPAILKQLLADTNTEPASIDWLLLHQANQRILDAAAERLGIAADKVLSNLANYGNTSAGTIPLMLHEAVSDGRIQSGQLIASSGFGAGLSWGAALLRWDGPTS
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR14_NYMAL
Sequence: MARKSLIQREKKRQKLEEKYHLIRRSSKKEISKVSSLDEKWEIHVKLQSPPRNSAPIRLHRRCFLTGRPRANYRDFGLSGHVLREMVHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PRPC_EMENI
Sequence: MALPLRTARHASRLAQTIGRRGYATAEPDLKSALKAVIPAKRELLAEVKKQGDEVIGEVKVSNVIGGMRGLKSMLWEGSVLDADEGIRFHGKTIKDCQKELPKGPTGTEMLPEAMFWLLLTGEVPSTSQVRAFSKQLAEESHLPDHILDLAKSFPKHMHPMTQISIITAALNTESKFAKLYEKGINKADYWEPTFDDAISLLAKIPRVAALVFRPNEIDVVGRQKLDPAQDWSYNFAELLGKGGANNADFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQEKIGTKFTDEDVRAYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRKDVLANPVFQLVKKNSEIAPGVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
What is the function of this protein?
Catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate and also from acetyl-CoA and oxaloacetate with a greater efficiency.  Also has citrate synthase activity and can substitute for the loss of citA activity.
What are the official names of this protein?
2-methylcitrate synthase, mitochondrial, Methylcitrate synthase, (2S,3S)-2-methylcitrate synthase, Citrate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SNX9_MOUSE
Sequence: MATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLVPTDYVEILPNDGKDPFSCGNSVADQAFLDSLTASTAQTNSSSANSNNQVGGGNDPWTAWNAPKPGNWDSSDAWGSRTDGTSAQRNSSANNWDTGFGHPQAYQGPATGDDDEWDEDWDDPKSSSPYFKDSEPAEAGGIQRGNSRAGASSMKLPLNKFPGFAKPGMEQYLLAKQLAKPKEKIAIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVVSESEVFQQFLNFRDEKEWKTGKRKAEKDELVGVMIFSTMEPEAPDLDLIEIEQKCDAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLAAVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGAHKGAIEKVKESDKLVATSKITPQDKQTMVKRVGTMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM
What is the function of this protein?
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis.  Required for efficient progress through mitosis and cytokinesis.  Required for normal formation of the cleavage furrow at the end of mitosis.  Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis.  Plays a role in macropinocytosis.  Promotes internalization of TNFR.  Promotes degradation of EGFR after EGF signaling.  Stimulates the GTPase activity of DNM1.  Promotes DNM1 oligomerization.  Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton (PubMed:23437151).  Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation.  Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
What are the official names of this protein?
Sorting nexin-9.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (By similarity). Colocalizes with the actin cytoskeleton at the cell membrane (By similarity).
Protein: SEC62_PONAB
Sequence: MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGLGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEEEEEENDGETPKSSHEKS
What is the function of this protein?
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER).  Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides.  Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
What are the official names of this protein?
Translocation protein SEC62, Translocation protein 1, TP-1.
What is the protein family that this protein belongs to?
Belongs to the SEC62 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS20_THEVB
Sequence: MANIKSAAKRAQIAERNRLRNKAYRSAVRTLIKNYLNAISQYSTDPTPEKLAEVHHRLNLAFSKIDKAVKRGVLHRNTGARRKARLTRILNKTLQPAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DUT_MYCTU
Sequence: MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: URM1_ORYSI
Sequence: MHLTLEFGGGLELLLEKSTKVHKVDLQPNDGDGKVVMKGLLAWVKSNLIKERPEMFLKGDSVRPGVLVLINDCDWELCGGLDAELEEKDVVVFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1 homolog, RURM1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF099_HUMAN
Sequence: MNAAVPPEQAHSCGWGTEGCPCLRSTAIRQTFFPGGDQFQRDGGLAMLPILVSKFLASSDPPVSVPEMLGLQNRWRGMKNEEHCPGSFFLCKIRECVLNYRFQLQHPGFQHYLQSSGRRDRGRSEDKKPLEAGVWCWDRGGWDGSSRAVHLLFRGVAHPSLYLFPREDPPRLLFPRLSLLVCEQFWCYSATLLLAPLPASTC
What are the official names of this protein?
Putative uncharacterized protein LINC02901, Long intergenic non-protein coding RNA 2901.
Protein: PSBA_PINKO
Sequence: MTAIIERRESANFWSRFCDWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENQSANAGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVAGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVESISIGG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.