PharMolix/UniProtQA huggingface dataset:
Protein: KIP3_YEAST
Sequence: MNVPETRQSSIVVAIRVRPFTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRSKRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSINNSNATNKFSSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGTPSQPGIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITEQKRQIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFLQMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVIHQVHSIDLNKLREMEDWDETYDLVYLESCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFNEQGPSTPSAPTTAVPRRKMRSSLLTHQSLLATARK
What are the official names of this protein?
Kinesin-like protein KIP3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with beta-tubulin TUB2 at the plus ends of growing microtubules and along the microtubule lattice.
Protein: WBP1_HUMAN
Sequence: MARASSGNGSEEAWGALRAPQQQLRELCPGVNNQPYLCESGHCCGETGCCTYYYELWWFWLLWTVLILFSCCCAFRHRRAKLRLQQQQRQREINLLAYHGACHGAGPFPTGSLLDLRFLSTFKPPAYEDVVHRPGTPPPPYTVAPGRPLTASSEQTCCSSSSSCPAHFEGTNVEGVSSHQSAPPHQEGEPGAGVTPASTPPSCRYRRLTGDSGIELCPCPASGEGEPVKEVRVSATLPDLEDYSPCALPPESVPQIFPMGLSSSEGDIP
What are the official names of this protein?
WW domain-binding protein 1, WBP-1.
Protein: RL6_STRP7
Sequence: MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIRVEGTEVTLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSKLVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGKGIRYIGEFVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PSBI_CUCSA
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NUOG_BUCBP
Sequence: MTIIFVDNEEYNVDKSDNLLQACLSSGINIPYFCWHPVLGSIGSCRQCAVTIYKDLEDKVGQLVMSCMTSVLDGMIVSTSDKISRNFRKGIIELLMLNHPHDCPICEEGGSCHLQDMTVMAGHTVRRYRFTKRTHKNQYLGHFITHEMNRCISCYRCVRYYKDYSGGTDLGVFGISNNVYFGRYNDGCLESEFSGNLVEVCPTGVFTDKTYSKKYSRKWDMQYAPSICQHCCVGCNISVGEKYGKISRIENRYHNAINHYFLCDLGRFSYDYSNVDERLTYSIYRSQNKTKIINDVNKTIDKLAMKFKKSSKIIGIGSCRASVESNFSLQKLVGSENFYLGISQKEYDCLMLIKDILKDNQIHVPTLREIEKSDVIFLLGEDVTKTSPLIALSIRQSIKGQVKTQDVSKNIPIWHADAVKNSFRNNKNKLFITNLMNSSLDDIADESYYASTFDQVLLGAEVYKCISNNCISNVTLLKQDLLSCAKRIATALTLSKCPLIISGSHSYNLDLIKVSFNIAKSLKVIGKNVGLILLSSNVNSIGVSLLEGISIEKVINKVLLKQIDKIIVLENDLYRYLPESIVDTLFKSSSCTVVIDHLNTRTLKQADIAIPTCNSFESSGTVVNYEGRAQRFFKTYHPNSSENKKSILESWKWLHLLYCKLHKISVFWHSLDDVIEEISLKIFSFSKLKDVAPNSSFKIFGQKLARSHHRASGRTALYSNINIHEPRPPQDNDTMFSFSMEGCQNVQNYLPYVPFSWFPGWNSVQSWNTYKKINNENYGKHLFQDTTKFVLTYYKLNCKNVNKIEDLYLIVPCYFLFCNNELAQYSPVIQENVLKNAYGIINTEDAKVLLIESGSKIEFSYLNKNFSIKVQLSKEFKKGQLGLPLGMADFPFFLAEKQVKVFRKISI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit G, NADH dehydrogenase I subunit G, NDH-1 subunit G.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
Protein: VATF_BOTFB
Sequence: MAAPASAYKDRQFLAVIGDEDSVTGLLLAGIGHVTSPPDSQKNFLVVDNKTDNAAIEEAFERFTTERKDIGILLINQHIAERIRHRVDTYTAAFPALLEIPSKDHPYDPEKDSVLRRVRRLFGE
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit F, V-ATPase subunit F, V-ATPase 14 kDa subunit, Vacuolar proton pump subunit F.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL33_NOVAD
Sequence: MAKPTTVKIRLVSTADTGFFYVTKKNPRNTTEKMTFRKYDPVVRKHVEFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: IND7_STRGR
Sequence: MHTDWETSESAEDYSRNTAAAQWEPMGYPAVFRSLALATTDSDNAPPILDYGCGPGFVDRHVAEKYGRRVIAVDISSSMIDLARSQHSHPLVTYRHVPDSQLDFLGDKEIGGCMSCFVLMQMADSDTQVEICRRIRRTLAPGAMLAVLNTHPDSVGIQFATLRNGEPDRVYQPGDPMTTVLTTDKGVLRLQDYYWRVTDYVHALEAAGFHEVTVEHLPPPPADPTPHPQFLLVRGTA
What is the function of this protein?
Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases.  Catalyzes the methylation of N-demethylindolmycin to yield indolmycin, with S-adenosylmethionine (AdoMet) acting as the methyl donor.
What are the official names of this protein?
N-demethylindolmycin N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: BIOB_BURP1
Sequence: MTEAQTACATTETPVAAPAAPRWRVADVIALYELPFNDLLFRAQQTHREHFDANAIQLSTLLSIKTGGCEEDCGYCSQSAHHDTGLKAEKLMEVDAVLAAARTAKENGATRFCMGAAWRNPKDRHIEPIKEMIRGVKDMGLETCVTLGMLEEHQAKALAEAGLDYYNHNLDTSPEFYGQIISTRTYQDRLDTLERVRDAGINVCCGGIIGMGESRRERAGLIAQLANMNPYPESVPINNLVAIEGTPLANAQALDPFEFVRTIAVARITMPKAMVRLSAGREQLDDAMQALCFLAGANSMFYGDVLLTTGNPRAEADRKLLARLGMWASEASQLSA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GRPE_WOLSU
Sequence: MNDNPANAEPQEEEVSLESQPSTPESGSDGSKEAELEAKIKELEDSYLRVHADFENTKKRLEREKFQALEYAYEKIAKDLLPIVDTLEIALKSANEVSGEESELQAKFKEGLELTLDNFSKVLQRHGIEMIACEGEFDPHLHECIMQVPSPSHQEGEIVQVFQKGYRYKERVLRPAMVSIAKSN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGD_CORGL
Sequence: MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPSGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQHDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_CALS4
Sequence: MTTANTNETAAAAAAKNRRNKKKKRVCAFCADNIDRIDYKDVARLRKYITERGKILPRRITGNCARHQRQLTKAIKRARQIALLPYTVE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RPOC1_SYNSC
Sequence: MTNSNLRTENHFDYVKITLASPDRVMEWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYVVLDPGDHKDLKYKQLLTEDEWLEIEDEIYAEDSEIENEPVVGIGAEALKQLLEDLTLDEVAEQLREEINGSKGQKRAKLIKRLRVIDNFIATNARPEWMVLDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQRADDEVMQVLQEVIEGHPILLNRAPTLHRLGIQAFEPKLVDGRAIQLHPLVCPAFNADFDGDQMAVHVPLAIEAQTEARMLMLASNNILSPATGEPIITPSQDMVLGSYYLTALQPGASKPDFGDRSCTFAGLEDVIHAFEDNRIGLHDWVWVRFNGEVQDDEELDAPSKSESLSDGTRIEEWSYRRDRFDEDGALISRYILTTVGRVVMNHTIIDAVAAA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: GLTB1_ARATH
Sequence: MAMQSLSPVPKLLSTTPSSVLSSDKNFFFVDFVGLYCKSKRTRRRLRGDSSSSSRSSSSLSRLSSVRAVIDLERVHGVSEKDLSSPSALRPQVANLEDILSERGACGVGFIANLDNIPSHGVVKDALIALGCMEHRGGCGADNDSGDGSGLMSSIPWDFFNVWAKEQSLAPFDKLHTGVGMIFLPQDDTFMQEAKQVIENIFEKEGLQVLGWREVPVNVPIVGKNARETMPNIQQVFVKIAKEDSTDDIERELYICRKLIERAVATESWGTELYFCSLSNQTIVYKGMLRSEALGLFYLDLQNELYESPFAIYHRRYSTNTSPRWPLAQPMRFLGHNGEINTIQGNLNWMQSREASLKAAVWNGRENEIRPFGNPRGSDSANLDSAAEIMIRSGRTPEEALMILVPEAYKNHPTLSVKYPEVVDFYDYYKGQMEAWDGPALLLFSDGKTVGACLDRNGLRPARYWRTSDNFVYVASEVGVVPVDEAKVTMKGRLGPGMMIAVDLVNGQVYENTEVKKRISSFNPYGKWIKENSRFLKPVNFKSSTVMENEEILRSQQAFGYSSEDVQMVIESMASQGKEPTFCMGDDIPLAGLSQRPHMLYDYFKQRFAQVTNPAIDPLREGLVMSLEVNIGKRGNILELGPENASQVILSNPVLNEGALEELMKDQYLKPKVLSTYFDIRKGVEGSLQKALYYLCEAADDAVRSGSQLLVLSDRSDRLEPTRPSIPIMLAVGAVHQHLIQNGLRMSASIVADTAQCFSTHHFACLVGYGASAVCPYLALETCRQWRLSNKTVAFMRNGKIPTVTIEQAQKNYTKAVNAGLLKILSKMGISLLSSYCGAQIFEIYGLGQDVVDLAFTGSVSKISGLTFDELARETLSFWVKAFSEDTTKRLENFGFIQFRPGGEYHSNNPEMSKLLHKAVREKSETAYAVYQQHLSNRPVNVLRDLLEFKSDRAPIPVGKVEPAVAIVQRFCTGGMSLGAISRETHEAIAIAMNRIGGKSNSGEGGEDPIRWKPLTDVVDGYSPTLPHLKGLQNGDIATSAIKQVASGRFGVTPTFLVNADQLEIKVAQGAKPGEGGQLPGKKVSAYIARLRSSKPGVPLISPPPHHDIYSIEDLAQLIFDLHQINPNAKVSVKLVAEAGIGTVASGVAKGNADIIQISGHDGGTGASPISSIKHAGGPWELGLTETHQTLIANGLRERVILRVDGGLKSGVDVLMAAAMGADEYGFGSLAMIATGCVMARICHTNNCPVGVASQREELRARFPGVPGDLVNYFLYVAEEVRGILAQLGYNSLDDIIGRTELLRPRDISLVKTQHLDLSYLLSSVGTPSLSSTEIRKQEVHTNGPVLDDDILADPLVIDAIENEKVVEKTVKICNVDRAACGRVAGVIAKKYGDTGFAGQVNLTFLGSAGQSFGCFLIPGMNIRLIGESNDYVGKGMAGGEIVVTPVEKIGFVPEEATIVGNTCLYGATGGQIFARGKAGERFAVRNSLAEAVVEGTGDHCCEYMTGGCVVVLGKVGRNVAAGMTGGLAYLLDEDDTLLPKINREIVKIQRVTAPAGELQLKSLIEAHVEKTGSSKGATILNEWEKYLPLFWQLVPPSEEDTPEASAAYVRTSTGEVTFQSA
What is the function of this protein?
Involved in glutamate biosynthesis in leaf.  Required for the reassimilation of ammonium ions generated during photorespiration.
What are the official names of this protein?
Ferredoxin-dependent glutamate synthase 1, chloroplastic/mitochondrial, Fd-GOGAT 1.
What is the protein family that this protein belongs to?
Belongs to the glutamate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Mitochondrion matrix. Note=Dual targeting is supposed to depend on alternative initiation: MET-1 or MET-3 for chloroplast or mitochondrion location, respectively.
Protein: VKT34_ACTEQ
Sequence: DANSFCQLPAVVGRCRGRFPRYYYNTEAGKCQRFIYG
What is the function of this protein?
Dual-function toxin that inhibits both the serine protease trypsin and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type proteinase inhibitor AEPI-IV.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: DER22_MAIZE
Sequence: MAQAVEEWYRQMPIITRSYLTAAVVTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYFRKMDLDFLFHMFFLARYCKLLEENSFRGRTADFFYMLLFGATVLTGIVLIGGMIPYISETFARILFLSNSLTFMMVYVWSKHNPFIHMSFLGLFTFTAAYLPWVLLGFSILVGSSTWVDLLGMIAGHVYYFLEDVYPRMTGRRPLKTPSFIKALFADDNVVVAQPPNAGIGAGARFGAIGVDPQAQ
What is the function of this protein?
May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
What are the official names of this protein?
Derlin-2.2, ZmDerlin2-2.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NQOR_AGRRK
Sequence: MAKVLVLYYSAYGHIEKMAYAVAEGAKSAGAEVTVKRVPELVPEEVAKASYFKLDQEAPIATPDELAEYDAIIVGAGTRFGTVASQMRNFWDQTGGLWFSGKLVGKVGSVFTSSATQHGGQESTILGFIPTLLHHGMAVVGLPYAFAGQMGTEEVKGGSPYGASTITNGDGSRQPSEIELEAAKYQGAHVAKIAAKLVA
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: YBDG_BACSU
Sequence: MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGKGTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR
What are the official names of this protein?
Uncharacterized protein YbdG.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: BNP_LACMU
Sequence: MFVSRLAASGLLLLALLAVSLDGKPVQQWSHKGWPPRPQIPPLVVQQWSQKPWPPGHHIPPVVVQEWPPGHHIPPLVVQQWSQKKWPPGHHIPPLVVQKWDPPPISPPLLKPHESPAGGTTALREELSLGPEAALDTPPAGPDVGPRGSKAPAAPHRLPKSKGASATSAASRPMRDLRTDGKQARQNWGRMMNPDHHAVGGGGGGGGARRLKGLAKKRVGDGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Bradykinin-potentiating and C-type natriuretic peptides, BPP-CNP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: AIFM1_MOUSE
Sequence: MFRCGGLAGAFKQKLVPLVRTVYVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGSSGGKMDNSVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLGLSPEEKQRRAIASATEGGSVPQIRAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSAPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
What is the function of this protein?
Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity).  In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:9989411, PubMed:12114629, PubMed:21467298).  Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (PubMed:21467298).  The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i. e.  caspase-independent fragmentation of chromosomal DNA (PubMed:9989411, PubMed:12114629, PubMed:21467298).  Binds to DNA in a sequence-independent manner (PubMed:21467298).  Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity).  Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity).  In contrast, participates in normal mitochondrial metabolism.  Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:19447115).
What are the official names of this protein?
Apoptosis-inducing factor 1, mitochondrial, Programmed cell death protein 8.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region. SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Cytoplasm, cytosol. Note=In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner.
Protein: SURA_PSEPF
Sequence: MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLDQQVLERLIVENLQLQIGERSGIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYEDAREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGKMQLSEELHLANILIPTPESANSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDRELSSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQSLYNRIEAGEDFAELAKKYSEDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPFQTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEELQTWLRQIRDEAYVEIKLPGADQAAQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: RIMM_STRPJ
Sequence: MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEKDQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYHEIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRVDVEILEGLDDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_THEAC
Sequence: METDDQYYRAIKKIKEAAEASNRAYLTSSKLADMLGISQQSASRIIIDLEKNGYITRTVTKRGQILNITEKGLDVLYTEFADLSRILAIKNNVVITGTVTSGMGEGRYYVARKQYIIQFQEKLGIIPYLGTLNIKVDQASLPELRKIRGFRGIHIEGFKTEDRTFGSVKAFPAKIQNIPCFVIMPERTVYTDVIEIISDKYLREEINLHDGDRVSVEVYT
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: APBB3_MOUSE
Sequence: MLGKDYMLAIILVNCDDDLWGDQNLEGETGLPPGWRKIRDAAGTYYWHVPSGSTQWQRPTWELPGAEDPGRGTEGIWELRPPKGRSFSSLDSSLNRSNSLTWYSEDSYVRSLEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRNRSQPHDGTWGEGQNMLMILKKDAMSLLNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVAGDKDSCMLKCHVFHCDVPAKAIASALQGLCAQILSERVGVSGEAACCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGILPVTKAMGMDVLNEAIGTLTARGDRKTWVPAMLSVSDSLMTAHAIQAEAGAEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGCQSFQCAAFWCEPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPPPLLKGGAGGAGAAPRKRGVFSFLDAFRLKPSLLHMS
What is the function of this protein?
May modulate the internalization of amyloid-beta precursor protein.
What are the official names of this protein?
Amyloid-beta A4 precursor protein-binding family B member 3, Protein Fe65-like 2, Fe65L2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UVRC_SERP5
Sequence: MSDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLVKNIAQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRGAKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVAGLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVTERQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFVGQFYLQGSQMRTLPAEILLDFTLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLARTNAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDISHTMGEQTVASCVVFDANGPLRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFNSLNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNHAITGHRQRRAKVRNTSALELIDGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQALAEKIYNALKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_PSEP1
Sequence: MKLNDLSPAPGSRREKHRPGRGIGSGLGKTGGRGHKGQTSRSGGSIAPGFEGGQQPLHRRLPKFGFVSLKAMDRAEVRLSELAKVEGDVISVQSLKDANVINQHIQRVKIMLSGEVTRAVTIKGIAATKGARAAIEAAGGKFEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.