PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_NEIM0
Sequence: MQVYYDKDADLSLIKGKTVAIIGYGSQGHAHAANLKDSGVNVVIGLRQGSSWKKAEAAGHVVKTVAEATKEADVVMLLLPDETMPAVYHAEVTANLKEGATLAFAHGFNVHYNQIVPRADLDVIMVAPKGPGHTVRSEYKRGGGVPSLIAVYQDNSGKAKDIALSYAAANGGTKGGVIETTFREETETDLFGEQAVLCGGVVELIKAGFETLTEAGYAPEMAYFECLHEMKLIVDLIFEGGIANMNYSISNNAEYGEYVTGPEVVNASSKEAMRNALKRIQTGEYAKMFIQEGNVNYASMTARRRLNADHQVEKVGAQLRAMMPWITANKLVDQDKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PNCB_XYLFT
Sequence: MEFIIKSLLDTDLYKFTMMQAVLHQYPGAQVEYRFKCRTPGVDLARFINEISHEIDGLCGLCFSKEELDYLRGLRFMKPDFVDFLGLFHLDRKYLQLRASSQVPGEIELDIRGPWLHTILFEVPLLAIINEVWFRNTSVLNLDVGRDRLDAKVRLLKDESGYEECSIADYGTRRRYSRQWHAELLPLLAQGLGSNFVGTSNVYFAKQYGYTPLGTMAHEYLQAFQALGPRLRDSQVAGLEAWAREYRGDLGIALSDVVGLDAFLGDFDLYFCKLFDGMRHDSGDPFKWGERIIMHLESHRIDPRTKVLVFSDGLDMNKVMRLYQHFRGRCRLAFGVGTSLTNDLGPTPLQIVIKMVRCNGQPVAKLSDSPGKSMCDDPGYLHYLRQVFGVSADV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: YU046_USTMA
Sequence: MSAPASSSAIAPSQPTAPGHARHSASWSASASDPSGATCAVAPCTSLTPPRTRFDASQLQAHLSSTLAARLRNASWDKSDKDKNRALSRSIAEVIKLKMLEIEPKGFKFIVQVQLVENLGQGGSRPGVSLARHGQCCTGHVFE
What are the official names of this protein?
Uncharacterized protein UM12046.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
Protein: SERI1_BOMMO
Sequence: MRFVLCCTLIALAALSVKAFGHHPGNRDTVEVKNRKYNAASSESSYLNKDNDSISAGAHRAKSVEQSQDKSKYTSGPEGVSYSGRSQNYKDSKQAYADYHSDPNGGSASAGQSRDSSLRERNVHYVSDGEAVAASSDARDENRSAQQNAQANWNADGSYGVSADRSGSASSRRRQANYYSDKDITAASKDDSRADSSRRSNAYYNRDSDGSESAGLSDRSASSSKNDNVFVYRTKDSIGGQAKSSRSSHSQESDAYYNSSPDGSYNAGTRDSSISNKKKASSTIYADKDQIRAANDRSSSKQLKQSSAQISSGPEGTSVSSKDRQYSNDKRSKSDAYVGRDGTVAYSNKDSEKTSRQSNTNYADQNSVRSDSAASDQTSKSYDRGYSDKNIVAHSSGSRGSQNQKSSSYRADKDGFSSSTNTEKSKFSSSNSVVETSDGASASRESSAEDTKSSNSNVQSDEKSASQSSSSRSSQESASYSSSSSSSTLSEDSSEVDIDLGNLGWWWNSDNKVQRAAGGATKSGASSSTQATTVSGADDSADSYTWWWNPRRSSSSSSSASSSSSGSNVGGSSQSSGSSTSGSNARGHLGTVSSTGSTSNTDSSSKSAGSRTSGGSSTYGYSSSHRGGSVSSTGSSSNTDSSTKNAGSSTSGGSSTYGYSSSHRGGSVSSTGSSSNTDSSTKSAGSSTSGGSSTYGYSSRHRGGRVSSTGSSSTTDASSNSVGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDSNSNSAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDSNSNSAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDASTDLTGSSTSGGSSTYGYSSDSRDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSDCGDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSDSRDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDASTDLTGSSTSGGSSTYGYSSSNRDGSVLATGSSSNTDASTTEESTTSAGSSTEGYSSSSHDGSVTSTDGSSTSGGASSSSASTAKSDAASSEDGFWWWNRRKSGSGHKSATVQSSTTDKTSTDSASSTDSTSSTSGASTTTSGSSSTSGGSSTSDASSTSSSVSRSHHSGVNRLLHKPGQGKICLCFENIFDIPYHLRKNIGV
What is the function of this protein?
Provides the silk fibroin thread with a sticky coating.  Acts as a cement by sticking silk threads together.
What are the official names of this protein?
Sericin 1, Silk gum protein.
What are the subcellular locations of this protein?
Secreted.
Protein: RS10_BURPS
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: Y1444_AQUAE
Sequence: MDIRELVHLGRYAVWNAFEGKEIKVPEALKEKYSRNMGVFTTLKTYPEHNLRGCIGVPLPVYPLWYATVYSSLQAAFQDPRFYPLKKEEFDKVLWEITLLTPPEELKVPKEELPEQIEIGKHGLIIEKGEQKGLLLPQVPVEYGWSPVEFLEYTCLKAGLPKDCWKDKETKVYVFSGEVYQEKEPFGEVERVNLK
What are the official names of this protein?
Protein aq_1444.
Protein: YBEY_KORVE
Sequence: MIILKKKLAGVSEQSLSLFLTRARKAAGVRGQVQVLVTSSDELRGLNRRFRRKDKATDVLSFPAIVDGEAGDIAISSDIASEYAYELGHSLDEELRILILHGVLHLAGHDHERDKGEMEALESELRDKLKLPSSLIERTTKPAKKAAKRKKR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_CALS4
Sequence: MRLYNTMTRTKEEFKPLKDKVVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYTVNYVQNFTDIDDKIINRAKEENTTEKEIAERFIEEYFKDADALGIKRATVHPRATEHIDDIIEFIKILIDKGYAYVVDGNVYFETAKFKDYGKLSHKNIDELMAGARVEIDEKKKNPLDFALWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLIFPHHENEIAQSEAAYDQPFSKYWMHIGYLNVNNEKMSKSKGNFFTVRELTEKYDPEVLRLFMLMAHYRSPINFSLDLLDQAKSAYERLSNAVVNLKHLANITKDRELSDEEKDLIVKFDEYKKQFEEAMDDDFNTADAISVLFEMAKTANANLSGNSSKKLVEYILEMFLKLSDVLGLSYKNAETEIEDEEILRLIEERQKARKEKNWKLADEIRDKLKERGIILEDTPEGVRWKRIR
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_CAMC1
Sequence: MSKIHVLNDKFENSGELELPASYAEVNPHNLYLYVKSYLAGIRANSAHTKSRAFVSGGGKKPWRQKGRGGARAGSTRTNVWVGGAVAFGPTNEKNYFQKVNKKQKRLALEYALAVKAQDGKIFAVDSISIESGKTKDAANIIKNLKVKDALIVKDLLDDKTLLAFRNLANCYVVDANEVNAYLVSTFSSVIIEKAALKTITKEG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: A4GCT_HUMAN
Sequence: MRKELQLSLSVTLLLVCGFLYQFTLKSSCLFCLPSFKSHQGLEALLSHRRGIVFLETSERMEPPHLVSCSVESAAKIYPEWPVVFFMKGLTDSTPMPSNSTYPAFSFLSAIDNVFLFPLDMKRLLEDTPLFSWYNQINASAERNWLHISSDASRLAIIWKYGGIYMDTDVISIRPIPEENFLAAQASRYSSNGIFGFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVWDTEPSFNVSYALHLWNHMNQEGRAVIRGSNTLVENLYRKHCPRTYRDLIKGPEGSVTGELGPGNK
What is the function of this protein?
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883).  Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883).  May protect against inflammation-associated gastric adenocarcinomas (By similarity).
What are the official names of this protein?
Alpha-1,4-N-acetylglucosaminyltransferase, Alpha4GnT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 32 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: AMP_TRIKH
Sequence: MKPHMSATVLRAPRVAAILLAVVLAAVLATAVNGAQRCGDQARGAKCPNCLCCGKYGFCGSGDAYCGAGSCQSQCRGCRDDVVGQALPAEPGSTRATAASSASARGLNLTATTGGP
What is the function of this protein?
Has antifungal activity against F. verticillioides (IC(50)=2. 7 ug/ml).  At concentrations between 45 uM and 225 uM, inhibits activity of metalloproteinase fungalysin Fv-cpm from F. verticillioides.
What are the official names of this protein?
Antimicrobial peptide 1b, WAMP-1b, Antimicrobial peptide H1, Tk-AMP-H1.
Protein: RHCG_PANTR
Sequence: MAWNTNLRWRLPLTCLLLQVVMVILFGVFVRYDFEADAHWWSERTHKNLSDVENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQGRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFKGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
What is the function of this protein?
Ammonium transporter involved in the maintenance of acid-base homeostasis.  Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism.  Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+).  As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity).  May act as a CO2 channel providing for renal acid secretion (By similarity).
What are the official names of this protein?
Ammonium transporter Rh type C, Rhesus blood group family type C glycoprotein, Rh family type C glycoprotein, Rh type C glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles.
Protein: RLMH_BIFLO
Sequence: MQIDIIAPGRVKERYLRDAIDEYSKRLSRYCKLNIIEVADEKTPDHASEGVDRQIKAREGERIAKHLKDGAFVIALAINGKQLSSEELAAKINDLGLRGTSHIQLVIGGSIGLDDAILRRADFLLSFSKMTFPHQLMRVILLEQIYRAYKINAGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPIIA_ARTOC
Sequence: MQFFTALAAVGALVAPALALPTQVPANQSLIDVQLSATGNSMIKAVITNKGTRALNLLKFNTIMDENPTAKVMVFDKNGAEVEFTGMLPRYDMNSLSTDYFATLAPQASVEHSFDIAATHNIKESGKYTLSAHGLIPTAEEHGTTITGQAFYESNTLEMEIDASKAAMVPRAFEELDAHIVGTIDKRSGIVTSSCDASQLRIVKQALANSRMLALNAARAASSNPSKVREYFGSSDSSIMQKVASRFQSVARESTASGGQTTYHCTDNRGSCKPGVLAYTLPSTNTVYNCPSYYREPSLTKRCHAQDQATTTLHELTHNPVVVSPFCKDLGYGYRLATGLPTSKAIQNADNYALFANEESSPVFFVPVFYSNG
What is the function of this protein?
Probable secreted metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine (By similarity).  May be involved in virulence.
What are the official names of this protein?
Probable neutral protease 2 homolog MCYG_05201, Deuterolysin MCYG_05201.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UVRC_CHLAB
Sequence: MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKKTTDIETILVSNETEAFLLENNLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTKAVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNREFASRKRPCILYEMKRCLAPCVNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQAMEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSFILQYYTNQPQTPKEILTPIPLNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVHAETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSHAVGVYIVYENDALSPKDYRTFSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVVSIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHKDFLLPKEKIPGIGEIKRKRLLQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDTYLED
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_PERMH
Sequence: MKKIGITLGDPSGISPEILIKSIDKLKKAIYVIYGSYKIIEKVSSILDKKTEINIIDSPEEAEKEGVYLINVYDRDFCVGKPDKETGKASVLFLERAVKDILSKKLDAIVTLPISKEYVMKAGFRYAGHTDYLADITKTEDYLMMLLCEKMKVALVTTHIPLKDVPENIKPEILESKIRLLNRELQSKFGIKKPKIAVLGLNPHAGDGGNIGREEIDIINPVVQKLKSEGIDLEGSLSADTAFNRYREFDAYLAMYHDQGLIPLKLLCFKKAVNITLGIPFIRTSPDHGTGFDIAGKGIADPSSFIEAVKLALKLSKQY
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOFN_SHIFL
Sequence: MNPPINFLPWRQQRRTAFLRFWLLMFVAPLLLAVGITLILRLTGSAEARIDAVLLQAEQQLARSLQITKPRLLEQQQLREQRSQRQRQRQFTRDWQSALEALAALLPEHAWLTTISWQQGTLEIKGLTTSITALNALETSLRQDASFHLNQRGATQQDAQGRWQFEYQLTRKVSDEHVL
What is the function of this protein?
Required for the use of extracellular DNA as a nutrient.
What are the official names of this protein?
Putative DNA utilization protein HofN.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HIS2_METBU
Sequence: MTDADMSVLNEVFDVIMDRKNNPVEGSYVCSLLDHRKGINKILEKVGEETAETILAVKDNDRAEIIYETSDLLFHLLVMLAATDITLDDIAEEMKKRRH
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YE12B_YEAST
Sequence: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-ER2 Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MACD1_RAT
Sequence: AAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFIKLKKIPMWKETAKGLAGKVENPKYKKDKQLNEKISLFRGDITKLEVDAIVNAANNSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPAKHVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLATLREWLEQHKDKVDRLIICVFLEKDEGIYQERLPHYFPVA
What is the function of this protein?
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety.  Inactive towards proteins bearing poly-ADP-ribose.  Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.  Plays a role in estrogen signaling.  Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen.  May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation.  Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction.  Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells.  Enhances ESR1-mediated transcription activity.
What are the official names of this protein?
ADP-ribose glycohydrolase MACROD1, MACRO domain-containing protein 1, O-acetyl-ADP-ribose deacetylase MACROD1, Protein LRP16, [Protein ADP-ribosylaspartate] hydrolase MACROD1, [Protein ADP-ribosylglutamate] hydrolase MACROD1.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
Protein: MAM_DROME
Sequence: MDAGGLPVFQSASQAAAVAQQQQQQQQQQQQHLNLQLHQQHLGLHLQQQQQLQLQQQQHNAQAQQQQIQVQQQQQQQQQQQQQQHSPYNANLGATGGIAGITGGNGAGGPTNPGAVPTAPGDTMPTKRMPVVDRLRRRMENYRRRQTDCVPRYEQAFNTVCEQQNQETTVLQKRFLESKNKRAAKKTDKKLPDPSQQHQQQQHQQQQQHQQHQQHQQAQTMLAGQLQSSVHVQQKFLKRPAEDVDNGPDSFEPPHKLPNNNNNSNSNNNNGNANANNGGNGSNTGNNTNNNGNSTNNNGGSNNNGSENLTKFSVEIVQQLEFTTSAANSQPQQISTNVTVKALTNTSVKSEPGVGGGGGGGGGGGSGNNNNNGGGGGGGNGNNNNNGGDHHQQQHQQQQQQQGGGLGGLGNNGRGGGPGGMATGPGGVAGGLGGMGMPPNMMSAQQKSALGNLANLVECKREPDHDFPDLGSLDKDGGGGQFPGFPDLLGDDNSENNDTFKDLINNLQDFNPSFLDGFDEKPLLDIKTEDGIKVEPPNAQDLINSLNVKSEGGLGHGFGGFGLGLDNPGMKMRGGNPGNQGGFPNGPNGGTGGAPNAGGNGGNSGNLMSEHPLAAQTLKQMAEQHQHKNAMGGMGGFPRPPHGMNPQQQQQQQQQQQQQQAQQQHGQMMGQGQPGRYNDYGGGFPNDFGLGPNGPQQQQQAQQQQPQQQHLPPQFHQQKGPGPGAGMNVQQNFLDIKQELFYSSQNDFDLKRLQQQQAMQQQQQQQHHQQQQQQQQPKMGGVPNFNKQQQQQQVPQQQLQQQQQQQQQQQQQQQQQYSPFSNQNPNAAANFLNCPPRGGPNGNQQPGNLAQQQQQPGAGPQQQQQRGNAANGQQNNPNAGPGGNTPNAPQQQQQQSTTTTLQMKQTQQLHISQQGGGAHGIQVSAGQHLHLSGDMKSNVSVAAQQGVFFSQQQAQQQQQQQQPGGTNGPNPQQQQQQPHGGNAGGGVGVGVGVGVGNGGPNPGQQQQQPNQNMSNANVPSDGFSLSQSQSMNFNQQQQQQAAAQQQQVQPNMRQRQTQAQAAAAAAAAAAQAQAAANASGPNVPLMQQPQVGVGVGVGVGVGVGVGNGGVVGGPGSGGPNNGAMNQMGGPMGGMPGMQMGGPMNPMQMNPNAAGPTAQQMMMGSGAGGPGQVPGPGQGPNPNQAKFLQQQQMMRAQAMQQQQQHMSGARPPPPEYNATKAQLMQAQMMQQTVGGGGVGVGGVGVGVGVGGVGGANGGRFPNSAAQAAAMRRMTQQPIPPSGPMMRPQHAMYMQQHGGAGGGPRTGMGVPYGGGAGGPMGGPQQQQRPPNVQVTPDGMPMGSQQEWRHMMMTQQQTQMGFGGPGPGGPMRQGPGGFNGGNFMPNGAPNGAAGSGPNAGGMMSGPNVPQMQLTPAQMQQQLMRQQQQQQQQQQQHMGPGAANNMQMQQLLQQQQSGGGGNMMASQMQMTSMHMTQTQQQITMQQQQQFVQSTTTTTHQQQQMMQMGPGGGGGGGGPGSANNNNGGGGGGAAGGGNSASTIASASSISQTINSVVANSNDFGLEFLDNLPVDSNFSTQDLINSLDNDNFNLQDFNMP
What is the function of this protein?
May have a regulatory function possibly in association with the Notch gene product.
What are the official names of this protein?
Neurogenic protein mastermind.
What is the protein family that this protein belongs to?
Belongs to the mastermind family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: AAEB_YERPB
Sequence: MTHPSFIRLRFAFKLSFAIVAALFLGFHLQLETPRWSVLTAAIVSAGPAFAAGGEPFSGAIRHRGWLRIIGTFIGCIGGLVIIVLTIRAPVLTLMLCCLWAGICTWISSLVRVENSYAFGLAGYTALIIIVTTGETPLLTPQFAVERCSEIVLGIVCAVMADLLFSPRSIKQDIDRLVDKVLVDQYRLLQLCIQPAEKSEIDRAWNELVKNTTSLNGMRSYLMMESSRWQRCNRRLQVLHTESLALITQACETYLVMSNHPEVISAELKTMLSEPAQTPAEIHQQMKKLRQFIAASHSEAIPHTISSWVGAATRYLLLSKGIQTNSSINQVEEDILAGDAPVKPISAEGHHAMINGLRTGIATAIGGLFWLWTGWTSGAGCMVMIAVVTSLAMRTPNPRRMALDFLVGVIIALPIGALYFMFIIPSTQQSMLLLCISLGVLAFIIGIEVQKRRLGSLGTLASTINIIVLSNPMIFNVRQFLDSALGQIVGCFVSLIVLLLIRDNAKDRTGRTLLNRFVYSAVSALTTNKTKRGENHLPALYQQLNQLLMMFPADIDKYRLALTLIIAHQRLNRTEIPVNAELSAFHKQIRSTAERVITVNNDQKRRYYFARLLQELDQYQQKLVDYQAADAVIRPVKRLTEMLRKYQSALI
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CBPK_DICDI
Sequence: MGNSKLSKEEKEEIIKKTKYTPEDIEQLIKDFKVAAASDKKSGFSQEEFIKFFKVRFSNWDEASMVRMFTLFDSDGNGVIDVKEFITALYLMAKAPTLDKLGFFFDLFDSDKSGYLEREEVDKLVNIVVCCGKGLGYSINDAIDYAVSITSCRHIADYQKGMSREEFIKSASQSENFVKVICFYESPCMQLY
What are the official names of this protein?
Calcium-binding protein K.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: RPO5_THEAC
Sequence: MAKFNVLDHNLVPEHHIVPEEEEKNILKELNIEKEFLPKISPNDPAIKALEAVHGKIKEGTIIKIVRKSPTMGHSVYYRVVASEVFK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_MYCSJ
Sequence: MTGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRFPGPLGLAAGFDKDGRGLHTWPALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMGFNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVEDYAQSARQLGPLATFLVVNVSSPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIVATNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETADDAWERITSGASLLQGYTGFVYGGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UPPP_CORDI
Sequence: MTQDPSSQISWSQTIVLSIVQGLTEFLPISSSGHLRIVSELFWGKDAGASFTAVVQLGTEAAVLVYFAKDIAKILTGWFRGLFDKKQRGFDYRMGWMVIVGTLPVSIVGLLAKDIIRDNLRNMWITASVLIAFSFVFIAAEKWGSKRRSFDQLTMRDAVIMGCAQCLALIPGVSRSGGTVSAGLFVGLDREVATRFSFLLAIPAVLASGLFSLPDAFAPDAGQAASGMQLAVGTGIAFALGYASIAWLLKFVGSHSFSWFAAYRIPVGLLVMALLATGMLTA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.