PharMolix/UniProtQA huggingface dataset:
Protein: USOM1_ACRMI
Sequence: KSNGMVSEGHAYFSQQLNFETPIRTENGTEISMIKMTVKSRVLLXGTVALIYPSPESIDFQGLFVKLFLSKPSPPVLSLNETTDAGQFSLNDTNEDPFAPLSRSRRAVSNSXNANASLVSEILERIGPVCLFFDRQFQLYSLNVNSVNLTLSASVSVQIDGPHTSRIDVSLVLSVGQNLTSVVIQKFVRMVSLQELSDVNLNFPPIFRFLRGSTSFLESNTDVRGRLVVLARFRLSLPLQNNSVDPPRLNLKIEPYAVIVVRRLIVAMSVBXIQQXVXARXVVXXSGPKVTLSFNDDQLCVTVSDRVIGPDVPVTFFRRLRVCRRIPRVGRLWVRTRRGWRLRRIFTFSRRCFWVIISGFRGRLSPTVTQEGFVRVCNITKAANPSILLPTPTSQIAQSISTAQMVSSTSASIFATPVLALQSSSLRISPASTAPTSATVSSPVASIS
What are the official names of this protein?
Uncharacterized skeletal organic matrix protein 1, Uncharacterized SOMP-1.
What are the subcellular locations of this protein?
Secreted.
Protein: VAPC9_PYRAE
Sequence: MPVEYLVDASALYALAAHYDKWIKHREKLAILHLTIYEAGNALWKEARLGRVDWAAASRHLKKVLSSFKVLEDPPLDEVLRVAVERGLTFYDASYAYVAESSGLVLVTQDRELLAKTKGAIDVETLLVRLAAQ
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system (By similarity).  Has ribonuclease activity.  Has a slow ssDNA exonuclease activity.
What are the official names of this protein?
Exonuclease VapC9, Putative toxin VapC9, Ribonuclease VapC9, RNase VapC9.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: RPOC_MESFL
Sequence: MENKNNKVIKIELASADTIRSWSHGEVTKPETINYKTLKAEKDGLFDEKIFGPTKNYECFCGKFKKANPMNKGKKCEKCGVELTESIVRRERMGHIELAEPVTHIWMVKVSPSRIASLLDLKSKELEEVVYFVSHIVLDPGTSKHFAAKEVLDLGVSKSQKTRSKLRPAIEEIVTLINDPAHRDTLKAERLLEELNNPTIPFSIDEATALISKYTDAKFGIGASAIEELLKQIDLDKEIEITKNTLDAIGPNADNSKLLKRLDILESLKRSNQKPEWMVLRVLPVIPPDIRPIIQLDGGRFTTSEINDLYRRIIIRNERLLKVKEMGAPSIIINNEKRMLQEAVDALLDNERKPRPIQGKDKRPLKSLTSVLKGKQGRFRQNLLGKRVDYSGRSVIAIGPDLKMYQAGIPREMALTLFKPFVIQWLQEHEYAENVKVAEKMILQNDPKIWEALEHVIKDRPVLLNRAPTLHRLGIQAFEPKLVKGKAIRLHPLVTTAFNADFDGDQMAVHVPITKEAVAEARALMLGSNAILGPKDGKAIVTPGQDIILGNYYATFEEKGQLGEGTMFAEITEAINAFDTGIVSLNAVIGIAVDALPAEKFTEEQRKGYLLTTVGKILFNQIFDASFPWINSSSIYDAKEAVNSFIFDFSKDINEAIAEYTIVTPIKKKELSIIIEIYFNKFGARKTAEMLDKMKDLGFKYSTKSGTTISAGDVVAFKHKYEEFAEADQKVAEITSFYNEGMLTKEEKKHRVIEVWSDVKDDIQKRLELVLKQDTKNPVFVMADSGARGNVSNFTQLVGMRGLMNDTKGDIKEIPIKSSFREGLSVSEYFVSTHGARKGMADLALKTADSGYLTRRLVDVSQEIVVVNEDCKANKGFEIESVIDTKHNNVIVPLKDRIVGRYSFNDIKDIKGNVIVAKDTLIESKEADAIIAAGITKVTIRSVLTCDNQKGVCQRCYGRNLATASLVKIGEPVGVIAAQSIGEPGTQLTMRTFHTGGVAGDADITQGLPRIKELLDVTTQKGSVAIIAEKAGVVSDIINKNGINTIVVTEEVNGTQIEKQYKTMYNAVLRVNKGDQVKPGKKLTEGSINLHDLLEVAGTTAVQNYILKEVQKVYRLQGIEISDKYIEIIVKQMLNKVKVIQSGESHLLQGEIVTQQKFKEVVTQCIREGLVPPVAKNQILGIKKAPLKSESWLSSASFQDTARVLTDAIIKGREDKLEGLKENIMLGNLIPAGTGLTGIEEVMEIAEEYHKNEY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PSBT_NYMAL
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPNKKMK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YCIU_ECOL6
Sequence: MDMDLNNRLTEDETLEQAYDIFLELAADNLDPADVLLFNLQFEERGGAELFDPAEDWQEHVDFDLNPDFFAEVVIGLADSEDGEINDVFARILLCREKDHKLCHIIWRE
What are the official names of this protein?
UPF0263 protein YciU.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: VRAC_STAAN
Sequence: MQHYLLDSNQRLNVSFSKDSVAAYYQCFNQPYRKEVPPLMCASLWPKFDLFKKYANSELILTKSAINQTQKIEVDTIYVGHLEDIECRQTRNITRYTMALTLTKNDQHVITVTQTFIKAMK
What are the official names of this protein?
Protein VraC.
Protein: SURE_RHIEC
Sequence: MRILLTNDDGVHAGGLAALERIARTLSDDVWIVAPETDQSGLAHSLSLSEPLRLRKISDKHFALRGTPTDCVIMGIRQVMDIKPDLVLSGVNSGSNVADDVTYSGTIAGAIEGTMQGVRSFALSQAYLYEDGARIVPWEVCETHAPALLEKLMVLDLPDGTFLNLNFPNCRPDEVDGAEVTMQGKLAFNLQVDARSDGRGFPYYWLKFGERAGAFIEGTDIHALKHNKISVTPLKLDLTDYSVTDRVARALGYGAQV
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA8_HUMAN
Sequence: MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867).  Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).  The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, Complex I-19kD, CI-19kD, Complex I-PGIV, CI-PGIV, NADH-ubiquinone oxidoreductase 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA8 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Mitochondrion.
Protein: YP197_YEAST
Sequence: MKRNIIYYTLRLLPHGIMLVHSLNQFIDEFFTVTERTTLDEMLELSWDTPTTRWVGQLEWPQKVVSLLEVWTNSDDFVNQIVNGQDTILTQVGFDDSIVGQWNSLLVDLTETSLVDQLSNSRVGWVTVSNVWFNQLQ
What are the official names of this protein?
Putative uncharacterized protein YPL197C.
Protein: YL516_MIMIV
Sequence: MIRLQTPIIKETIHPKKTPTALNWLYPEKIIHNISSKALIDNIYSENYQHILVGLISLIEPWVYLHTNLKLIDNGHLPLIDDETIILISSGEYMIDYYYRIEVNKYGKQTDLFDKLLQSVNNSNKDFFDKYKNYFKISGIDFDLNINTSNTNRFEIIEKYVIESLVEILDKITDGLDAIYNYDNQRDVLLPIFNNNYNNDNVESIDIDYDLDLLKKVKTIMANPTFKFDKDLMFHPTKSLIMEARETNYRVFNDLGNQIDAIMKNSNNIMIFPYAYFLIKNVHGKNDYPNSSYKKFDNIIINQLNQYFIELSNGEIYSNYHKNAFFVDSINGFRSINHDLYLKRFNDFVPEENNNNAFYDTIKFPNITQVNNMEIIPSDSFYIYNQGKEVIDSIVEKKHNIVVNQSKAKATRSNTYIIDKDTIELNLSVVFKGLLFNNKPVVYPISSNIVTFEIERINSTNYVDNVNVPYQVLQIKNPKVTIKTYDRKTLINKLMKKLFDEDHFLPWYIPNYNQNIVKLLFLINLDKHEYIDFLKKLLQTQNKKELVDYSLYYCFDYQSYSFYNLIWIDPMTVDRYYEIQYLIKFIIIMDNILLLPDVSLRKILIDFNSSYGWYDPNVDLSSVKVSYQNFKNNLLNTLNELDDIYHNKSK
What are the official names of this protein?
Uncharacterized protein L516.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L515/L516 family.
What are the subcellular locations of this protein?
Virion.
Protein: LPXA_ACTP2
Sequence: MRLIDSTAKISPLAVVEEGAQIGAHVEIGPFSVIGKNVKIGAKTVIHSHVVINGHTEIGEQNQIFQFASIGEINQDLKYQGEPTKVIIGDRNRIRENVTIHRGTVQGGGVTRIGNDNLFMINTHIAHDCSIGNRCIIANNGTLAGHVTLDDFVIVGGMSAIHQFVVIGSHVMLGGGSMVSQDVPPYVMAQGNHAQPFGVNLEGLKRRGFDKPAMHAIRNAYKLIYRSGKTIEEAIPEIEQFAVNEPAVQLFLDFFKRSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDM5C_CRIGR
Sequence: QDWFHGRCVTVPRLLSSQRPGFTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESKPEESLAYSSDAGEGAGHIPKVQGLLENGDSVTSPEKVATEEGSGKRDLELLSSLLPQLTGPVLEL
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.  Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.  Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.  Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.  Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
What are the official names of this protein?
Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, [histone H3]-trimethyl-L-lysine(4) demethylase 5C.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_LISMO
Sequence: MIKGIGLDMIDLERVKQVVEKNPRFIERVLTEKEIKQFEKYEGNRKIEFLAGRFAAKEAYAKANGTGFGKHLSFTDVEILQVEDGRPHVTLPVKSGENVFVSITHTARSAAAQVIIEI
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AES_SHIB3
Sequence: MKPENKLPVLDLISAEMKTVVNTLQPDLPSWPATGTIAEQRQYYTLERRFWNAGAPEMATRAYMVPTKYGQVETRLFCPQPDSPATLFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYPLSPEARFPQAIEEIVAACCYFHQQAEDYQINMSRIGFAGDSAGAMLALASALWLRDKQIDCGKIAGVLLWYGLYGLRDSVTRRLLGGVWDGLTQQDLQMYEEAYLSNDADRESPYYCLFNNDLTREVPPCFIAGAEFDPLLDDSRLLYQTLAAHQQPCEFKLYPGTLHVFLHYSRMMKTADEALRDGAQFFTAQL
What is the function of this protein?
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons).  Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate.  Negatively regulates MalT activity by antagonizing maltotriose binding.  Inhibits MelA galactosidase activity.
What are the official names of this protein?
Acetyl esterase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMG_SALAR
Sequence: MSHVDDGFRSLTLKRFPQTDDVNPLLAWEAADEYLLQQLDETEIRGPVLILNDTFGALSCALAEHSPYSIGDSYLSELGTRENLRHNGIAESSVMFLDSTADYPQAPGVVLIKVPKTLALLEQQLRALRKVVTAQTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFSNPQLADAPQTLSWKLEDTGWTIHNHANVFSRTGLDIGARFFMQHLPENLEGEIVDLGCGNGVIGLSLLAKNPQANVVFVDESPMAVDSSRLNVETNMPEAFERCEFMINNALSGVEPYRFNAVFCNPPFHQKHALTDNIAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCATIATNNKFVILKAVKPGRRR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL01_HCMVA
Sequence: MGMQCNTKLLLPVALIPVVIILIGTLVPILLHEQKKAFYWRLFLQSQHVEAPITVTQGDTVYLDASNNPCNYSSFWYHGNCELCGWNGYLRNVTHYYTNTSCSPQFMCINETKGLQLYNVTLNDSGAYTEHVYECDLSCNITTYNEYEILNYFDNCNYTINSTKHIITVVSSRHSKQTNSHVSTHAGWAAAVVTVIMIYVLIHFNVPATLRHKLRTRNNVNRIA
What are the official names of this protein?
Glycoprotein UL1.
What is the protein family that this protein belongs to?
Belongs to the RL11 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: MSH2_NEUCR
Sequence: MSSRPELKVDDEHGFIRFYKSLPQLGEEAIRIFDRGDWYTAHGDDATFIARTVYKTTSVIRQLGRSDHTGLPSVTMTVTVFRQFLREALFKLGKRIEIWASPSGRMNWKVVKQASPGNLQDVEDELGGQFEGAPVILAVKISAKASEARTVGVCFADASVRELGVSEFLDNDLYSNFEALLIQLGVKECIVTQDKGEKEKDPELAKLRQIIDNCGVAIAERSAGEFGTKDIEQDLSRLLKDERAASLLPQTDLKLAMGSASALIKYLGILHDPSNFGQYQLYQHDLAQFMKLDAAALKALNLMPGARDGAKNMSLYGLLNHCKTPVGSRLLSQWLKQPLMNAEEIEKRQQLVEAFANDTELRQSMQEEHLRSIPDLYRLSKRFQRGKATLEDVVRAYQVVIRLPGFIGTLEGVMDEAYRDPLDEVYTNKLRELSDSLVKLQEMVETTVDLDALDNHEFIIKPEFDDSLRIIRKKLDRLRTDMDNEFAEAAEDLGQEREKKIFLENHKVHGWCMRLTRTEAGCIRNNSRYLECSTQKNGVYFTTKTLQALRREFDQLSQNYNRTQSSLVNEVVGVAASYCPVLERLAAVLAHLDVIVSFAHCSVHAPISYVRPKIHPRGTGRTVLTEARHPCMEVQDDVTFITNDVTLTREDSSFLIITGPNMGGKSTYIRQIGVIALMAQIGCFVPCSSAELTIFDSILARVGASDSQLKGVSTFMAEMLETANILKSATAESLIIIDELGRGTSTYDGFGLAWAISEHIVKEIGCFALFATHFHELTALADQYPNVKNLHVTAHISGTDTDTDVITDEDEKAKKKREVTLLYKVEPGICDQSFGIHVAELVRFPDKVVRMAKRKADELEDFTSKHEEENGGGLGVQYSKQDVEEGSALLKDVLVKWKDEVKSGRMSKEEMVARLKELVQKDERLLGNPFFKSVQAL
What is the function of this protein?
Involved in post-replicative DNA-mismatch repair.  Binds to mismatch-containing DNA (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh-2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDXS_BIFAA
Sequence: MANNRNELNKNLAQMLKGGVIMDVTTPEQAKIAQDAGACAVMALERIPADIRAAGGVSRMSDPAMIKGIQEAVSIPVMAKVRIGHIAEARILQAIEIDYIDESEVLSPADDVYHIDKNRFDVPFVCGAKNLGEALRRVAEGASMIRTKGEPGTGDVIQAVRHMRTMNKQIRELVSLRDDEVYEAAKQLAVPYDLAKYVHDNGRLPVVNFAAGGVATPADAALMMELGAEGVFVGSGIFKSGDPAKRAAAIVQATANWQDAELLARLSENLGEAMVGINEDEIETIMAARGE
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: ENCAP_MYCTU
Sequence: MNNLYRDLAPVTEAAWAEIELEAARTFKRHIAGRRVVDVSDPGGPVTAAVSTGRLIDVKAPTNGVIAHLRASKPLVRLRVPFTLSRNEIDDVERGSKDSDWEPVKEAAKKLAFVEDRTIFEGYSAASIEGIRSASSNPALTLPEDPREIPDVISQALSELRLAGVDGPYSVLLSADVYTKVSETSDHGYPIREHLNRLVDGDIIWAPAIDGAFVLTTRGGDFDLQLGTDVAIGYASHDTDTVRLYLQETLTFLCYTAEASVALSH
What is the function of this protein?
Shell component of a type 1 encapsulin nanocompartment in situ; its cargo protects against oxidative stress at low pH.  In situ and in E. coli assembles into proteinaceous shells about 22 nm in diameter with 2. 5 nm thick walls (PubMed:34751132, PubMed:24855650).  Cargo proteins are targeted to the interior via their C-terminal extensions; empty intact shells can be isolated in E. coli in the absence of cargo protein.  There are at least 4 possible cargo proteins, DyP (encoded in the same locus), FolB, BfrB and Rv1762c; DyP and Rv1762c have been identified in vivo (PubMed:24855650).  Probably involved in protection against oxidative damage from the host immune response (Probable) (PubMed:34751132).  A T-cell antigen found in bacterial culture cell filtrates, stimulates mouse immune response.  Does not have detectable bacteriocin activity (PubMed:9596740).
What are the official names of this protein?
Type 1 encapsulin shell protein, Culture filtrate protein 29, CFP29.
What is the protein family that this protein belongs to?
Belongs to the encapsulin family. Family 1 subfamily.
What are the subcellular locations of this protein?
Encapsulin nanocompartment. Secreted. Cell membrane; Peripheral membrane protein. Note=Encapsulin microcompartments of this protein encapsulating DyP are found in situ (PubMed:34751132). Detected at low levels in short-term culture filtrate, the nanocompartment is very stable and may survive cell lysis, explaining its apparent secretion (PubMed:9596740) (Probable). Detected in infected host (mouse J774 cell line) exosomes (PubMed:20662102).
Protein: GN_VZVO
Sequence: MGSITASFILITMQILFFCEDSSGEPNFAERNFWHASCSARGVYIDGSMITTLFFYASLLGVCVALISLAYHACFRLFTRSVLRSTW
What is the function of this protein?
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity.  Also plays a critical role in virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein N.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein N family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Protein: MNTH_ACICJ
Sequence: MSDLVSRPGLSERTARAVADRLAGRAGWRNPLIFAGPAVVASIAYMDPGNFATNIQAGARYGYDLLWVVLLASLIAMLFQGLSARLGIVTGRNLAELCRDTLPPALTIPMWIISEIAAMATDLAEFLGGAIGIALLAHLPLMAGMAITGIVTYGILLLDRRGFRPMELVIGALVGVIALCYLAELLIVPVHWRQAALHTVLPSLPDAEALTIAVGIVGATVMPHALFLHSGLSGARVAPQDAAQRRRLVRYSNIEVLAALGVAGMVNMAMVAMAAGAFHPAHQGIAEIGEAYRTLSPLLGAGAAVIFLISLLASGVSSSVVGTLAGQMVMQGFVGFSIPIWLRRALTMIPGFVVIGLGVNPTRALVLSQVVLSLALPVPMLALLWFSTRRALMGALAVRGITAIAAIGGAIVILGLNVILLLQIFGVNVPLPG
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RAP1A_MOUSE
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
What is the function of this protein?
Induces morphological reversion of a cell line transformed by a Ras oncogene.  Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.  Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity).  Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.  Plays a role in the regulation of embryonic blood vessel formation.  Involved in the establishment of basal endothelial barrier function.  May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
What are the official names of this protein?
Ras-related protein Rap-1A, Ras-related protein Krev-1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell junction. Cytoplasm. Cytoplasm, perinuclear region. Early endosome. Late endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Localized with RAPGEF2 at cell-cell junctions.
Protein: RLME_ANAPZ
Sequence: MRSSNLTTTVHFLSPVFAAFFPSHGTEQEDAPIVRVKTAKGRKISSTNWIRRQVNDQYVSLAKKEGYRSRSAYKLIEINDKFKILQRGRFVLDLGSSPGGWAQVASKNTAIIDSTEPTVVAVDIQSMKDIHNVSFVQCDIDSDHDLLNEKLSGRKFDVVLSDMAPKSCGHRQVDHANIINLCELARDIALEYLNPNGSFVTKLLHGEYEQEFRRSIMTHFGVVSYFKPKSSRKDSSEIYLVALKFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUS_HMPVC
Sequence: MSWKVVIIFSLLITPQHGLKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCSDGPSLIKTELDLTKSALRELKTVSADQLAREEQIENPRQSRFVLGAIALGVATAAAVTAGVAIAKTIRLESEVTAIKNALKTTNEAVSTLGNGVRVLATAVRELKDFVSKNLTRAINKNKCDIDDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISLDLMTDAELARAVSNMPTSAGQIKLMLENRAMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSGKKGNYACLLREDQGWYCQNAGSTVYYPNEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSTGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPIKFPEDQFNVALDQVFENIENSQALVDQSNRILSSAEKGNTGFIIVIILIAVLGSSMILVSIFIIIKKTKKPTGAPPELSGVTNNGFIPHS
What is the function of this protein?
Major determinant of the species specificity of RSV infection (By similarity).  The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate (PubMed:22238303).
What are the official names of this protein?
Fusion glycoprotein F0, Protein F.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: FLIM_RHIME
Sequence: MSTSTASNVHAFDRRLIARMTGALGDDKVIGRTALELAQVFDELLPGVLQSETGCDVTIAYAGFRTGLRNELIAALGDGVLLGDLSLRNWCADFQVGCDSPVLIALVEALLGAEPTSIEEPAPRSLSKIEIDVALPVFHGIAEVLRTAVNAPGGFEPVVGRPYNSAERAKPDPVLQDVFAASIDMTIGLGPVLSTFSVIVPQSTLLKTRVVSRKGAGEDRNAKTEWTEQLEEQVRRSAVALEARIRLESLTLDTLSRLQAGDVIPFHDGQDVRVEVSANGRDLYVCEFGRSGSRYTVRVKDTHGSEQDILRHIMS
What is the function of this protein?
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliM.
What is the protein family that this protein belongs to?
Belongs to the FliM family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body.
Protein: METXA_PELPD
Sequence: MSVSIVREQSITISDGIRLDSGRILAPITIAYETYGTLNTDASNAILVEHAWTGSAHLAGKQSENDTKPGWWDAIVGPGRLLDTDRYFVICSNVIGSCFGSTGPASINPKTGKRYNLTFPVITIRDMVRAQKLLIEMLGIRRLLSVMGGSMGGMQTLEWITQYPDAIASAVLLATTPRPSPLAISMNAIARWSIFNDPTWRKGEYKNNPKDGLALARAIGHITFLSDESMQAKFGRKFSARDGQFDFFGQFEVERYLDYNGYSFVSRFDANSFLYLAKALDLYDVSWGYESMAEAFARVSAPLQFFAFSSDWLYPPGQTEEMVSCLRKLGKEVEYHLISSSYGHDAFLLEHEAFSPLVKRFLDAAYAKGGQ
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKTH7_BUNCA
Sequence: MSSGGLLLLLGLLTLWAELTPVSSRKRHPDCDKPPDTRICQTVVRAFYYKPSEKRCVQFRYGGCKGNGNHFKSDHLCRCECLEYR
What is the function of this protein?
Beta-bungarotoxin is a presynaptic neurotoxin of the venom.  The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic (By similarity).
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B2b chain.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROE_MARMM
Sequence: MIPTGAAFVAGVTGDPIAHSLSPVVMRHWIDAAGIDALYAPFPISAGNFDRVVRGLAGAGCRGLNVTLPHKEAALELARTASGPARAVGAANLLTFTPAGIHADNTDIAGFLYALAPANVEFRKARALIFGAGGAARAMLYALLTVGVTDVAICNRNITRAQGLSRDIAPDAGIIPWEARDDALQGRDLIINATSLGLAGRDELALDWQRVRPGSVAFDGIYIPVNTRFIVESRARGVTAIDGLDMLIGQARPSFEAFFGRPAPDLPDMRSRLLEHLGAR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.