PharMolix/UniProtQA huggingface dataset:
Protein: AGRB_STAEQ
Sequence: MKIIDKKIEQFAQYLQRKNNLDHIQFLKIRLGMQVLAINIEKSIVVYGLAIIFHTFFYTLLTHLSYFLIRRHAHGTHANSSLLCHIQNIIFFIIFPYLIIKLDINYFVLLSMALVGLIITILYAPAATKKQPIPRRLVKRKKILSIFLYCTIVVISLVTKEPVNKLILFGVILESLTLLPIFFPKEDINHGKHF
What is the function of this protein?
Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP).  This quorum sensing system is responsible for the regulation of the expression of virulence factor genes.  Involved in the proteolytic processing of AgrD, the precursor of AIP.
What are the official names of this protein?
Accessory gene regulator protein B.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VIRAL_RHIRD
Sequence: MTWDRLLPSRKFLLAINSWYVLALVVAAISFAVLAIGPWKNEKSIEAILTELQSIDVDCALLQRNVLRAHAGLLRNYRPLMVPLGRVRSSIANLQQLFKKARVEDVGELSELLARLKSSINTTDAAVASFGAQNVVFEDSLATFNQSISSLLRTSDSRDLNAAKVPELGYLMLQFSFRPNTELALQITQSLDQLQMSTNADKVAIQEVVRNGRVILGVLPRLNETVKLVQASGTFENTKKLQRAYLEADSLARVVEQRVRTFLGAVSVFFCFGIVILVHKLRRRTDRLARRLDFEEVIKKIGVCFEDSTETKQSLKSSAEAALGTIENFFEANQCVLGLVNVTENEIAETFSASAPPPSWNERRIRKIVSLVQADEHGSIFRDYPARKASCFNEDAPGRWALVAFKVSDRLVAVFGLRFDRDPVQPASSEVQLMELAAGCVSHYVVIRCKQTQRDILERRLKHAERLEAVGTLAGGIAHEFNNILGVILGYAMAQNILHRRTYARHYIDRINAESNRARLIIDQILALSRRRERTARPFNLSALVREIAPSLRVALPSEVEVDFNIQSAQMIVEGNPLEIEQILMNLCKNAAEACIGTGRIEDSVYRSFVWKHKVLANGTIPAGDYILLSFEDNGGGIGQAALPHIFEPFFRTRAQCGGTGLGLSTVHGHVSAMAGFVDVISTVGRGTRFDIYLPTSAKKPVNSESFFGPEKIPLGSGEIVAVVEPDPVTLERYEETIAAFGYEPVGFNTFKGLTDWVLAGKEADIVLIDHSSFLDGERVGSWVATLEKVPIIMIGQHQKNVSISADGEASNHFLQKPVSSKALAYVVRANIRTE
What are the official names of this protein?
Limited host range VirA protein, LHR VirA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFG_PASMU
Sequence: MARTTPIERYRNIGISAHIDAGKTTTSERILFYTGVSHKLGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMSKQYPQHRINVIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYQVPRVAFVNKMDRTGANFLRVVEQIKTRLGGNSVPLQLPIGSEDNFKGVVDLVKMKAINWNEADQGMTFTYEEIPADMVDACEEWRQNLVESAAEASEELMEKYLGGEELTEEEIKAGLRQRVLAGEIIPVCCGSAFKNKGVQAMLDAVIDYLPAPTDIPAIKGINPDETEGERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVINSGDTVLNSVKDKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVGTGDTLCAQDAPIILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMRREFKVEANIGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGVIPGEYIPAVDKGVQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAAFNKANPVLLEPIMKVEVETPPDYVGDVIGDLSRRRAMVNGQEANEFVVKINAEVPLSEMFGYATDLRSQTQGRASYSMEPLKYAEAPKNVADAIIEARKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NONO_MOUSE
Sequence: MQSNKAFNLEKQNHTPRKHHQHHHQQHHQQQQQQQQQQPPPPIPANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGGAMGINNRGAMPPAPVPPGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRPAPGAEFAPNKRRRY
What is the function of this protein?
DNA- and RNA binding protein, involved in several nuclear processes.  Binds the conventional octamer sequence in double-stranded DNA (PubMed:8355702).  Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity).  Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity).  Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity).  Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity).  The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity).  The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity).  The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity).  In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity).  NONO is involved in transcriptional regulation (By similarity).  The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity).  NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (PubMed:9001221).  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205).  Important for the functional organization of GABAergic synapses (PubMed:26571461).  Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461).  Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (PubMed:32286661).  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity).
What are the official names of this protein?
Non-POU domain-containing octamer-binding protein, NonO protein.
Protein: DBH_BUCAI
Sequence: MNKTQLINVISKKSNLSKIQAKLTLETTLSTIIDSLKKGESVQIVGFGTFKVNLRSSRTGRNPQTGKEIQIPATKVPSFTSGKTLKNAIKQL
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: BSHB1_BACCR
Sequence: MSGLHILAFGAHADDVEIGMAGTIAKYTKQGYEVGICDLTEADLSSNGTIELRKEEAKVAARIMGVKTRLNLAMPDRGLYMKEEYIREIVKVIRTYKPKLVFAPYYEDRHPDHANCAKLVEEAIFSAGIRKYMPELSPHRVESFYNYMINGFHKPNFCIDISEYLSIKVEALEAYESQFSTGSDGVKTPLTEGYVETVIAREKMFGKEVGVLYAEGFMSKKPVLLHADLLGGCK
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  Catalyzes the second step of the pathway, the deacetylation of N-acetylglucosaminylmalate (GlcNAc-Mal) to glucosamine malate (GlcN-Mal).
What are the official names of this protein?
N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1, GlcNAc-Mal deacetylase 1, B.cereus zinc-binding protein, BcZBP.
What is the protein family that this protein belongs to?
Belongs to the PIGL family.
Protein: PAHO_PIG
Sequence: APLEPVYPGDDATPEQMAQYAAELRRYINMLTRPRYGKRDEEDLLDLKCSSLHAAAPRELSPMGA
What is the function of this protein?
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
What are the official names of this protein?
Pancreatic polypeptide prohormone.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPNP_SORC5
Sequence: MLKHNSYFNGNVQSVGFERHGRRQTVGVIDTGEFHFSTDAPERMTVVAGELAIRVDGSTEWRAYPAGTSFEVAGKSGFDVRATQPAGYLCEFL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: DTD_STRGR
Sequence: MRAVVQRVDGASVSVAGATDDPSAPGVVGEIVGEGLCVLVGVTHDDTPQKAAQLARKLWSVRVLEGEKSCSDVNAPLLVISQFTLYGDARKGRRPTWNAAAPGEVAEPLVDEVVAQLRALGARVETGRFGADMRVSLTNHGPFTVIIEV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_ERWT9
Sequence: MSPDTLIIRQLGLQPWAPVSLAMHQFTDQRNDETPDEIWLVEHLPVFTQGQAGKSEHLLMPGDIPVMQSDRGGQVTYHGPGQQVMYVMINLKRRRVGVRQLVTAIEQTVVDTLAAFSVSANARSDAPGVYVDGKKICSLGLRIRQGCSFHGLALNVDMDLSPFQRINPCGYAGLEMTQLTQQHPGATLAAVQPLLIAHFAHHLAITDIDWREDPSLPFSSLRH
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H32_TETEL
Sequence: MARTKQTARKSTGAKAPRKQLASKAARKSAPATGGIKKPHR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NPC1A_CAEEL
Sequence: MKQLLIFCLLFGSIFHHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNKLCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTFGGQPALRVMCTSTPCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVFTSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTITLDDVCYRPMGPGYDCLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNMVFGKNSTNHQAANSIMMTILVTQRTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKSPCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRGRIQASQFMTFHKKLSISNSSDFIKAMDTARMVSRRLERSIDDTAHVFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIVAFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGGSRGHGSSETSTNDNDEQHDACVLSPTAESHISNVEEGILNRPSLLDASHILDPLLKAEGGIDKAIDIITIDRSYPSTPSSLPCTSRMPRAHIEPDLRSL
What is the function of this protein?
Involved in the uptake or utilization of cholesterol (By similarity).  Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons (PubMed:10801441).
What are the official names of this protein?
NPC intracellular cholesterol transporter 1 homolog 1, Niemann-Pick C1 protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IRE1L_ARATH
Sequence: MWLLAISLVGLLVVVVCVFLRFSKDKGLDGIVNEKKRDKNSAPRVSASGEDGTKNEQVEKKSDPSGGLGEENEKTNSESKVLSVPSDQNINKTLPVMLPSLELRKYDENETPGKVVNRRLLVSTNEMKYGRNGYEVFQGVYGRRSSVAVKCLDLAHTTEAFIQNEIDNHCLCDDHSNIIRFHGLEQDQSFAYICLEPWKCSLDDLIKLSVRRTKRDTQAVAPVDDLEKVMKRIKFWKEKGKPLPLTPMLKLMRDVVCGLAHLHKLKTIHRNLNPQNVLIIVKDMTLTAKISDMSLSKHLGGKKSSYKHLATCSGSSGWQAPEQLNKDKKKKEDFPADMFNFGCLLHYAVMGTHPFGSPSERDTNIKTNNKTNLSLVTNLEAINLIEQLLNYKPDLRPSATQVLLHPLFWDSEKRLFFLREASDRIELDITMWGDLNKTIAPRVLGESKDWASKLGKTFITHIENLAQAQPGQESRQYNRSYKYWSLRHLLRLIRNILSHHREILDDPKIKEMVGKVPEGLDIFFTARFPNLMMEIYAFISMHCKGEEAFEKYFN
What are the official names of this protein?
Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like, Endoplasmic reticulum-to-nucleus signaling 1-like, Inositol-requiring protein 1-like.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: PSBB_COFAR
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTVTNAGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAIGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKIGDPTTRRQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GP2_CANLF
Sequence: MVGSYVLWLALASCILTLASPEQQGNRNLINTRSYDPCQNYTLLDEPSRSTENTEGSQVCDKDKHGWYRFVGDGGVRMPETCVPMYRCQTDAPLWLNGTHPTLAEGIVNRTACAHWSGNCCLWKTVVQVKACPGEFHVYRLEGTPKCSLRYCTDASTATDKCKNLCRPEEACSFLNGTWDCFCRSDLNSSDVHSLQPRLNCGAKEIQVSLDKCQLGGLGFGDEVIAYLRDWNCSNMMQREERNWISVTSPTQARACGNILERNGTHAIYKNTLSLANEFIIRDTILNINFQCAYPLDMKVSLQTALHPIVSSLNISVDGEGEFTVRMALFQDQSYISPYEGAAAVLAVESMLYVGAILEKGDTSRFNLLLRNCYATPTKDKTDPVKYFIIRNSCPNQYDSTIHVEENGVSSESRFSVQMFMFAGNYDLVFLHCEIHLCDSLNEQCQPCCSRSQQRSEIVALNPARVLDLGPITRRSSASVDITDGTPSTAGFLLAWPMLLLPILLAELF
What is the function of this protein?
Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria.  At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip.  Internalizes bound bacteria, like E. coli and S. typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
What are the official names of this protein?
Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75.
What are the subcellular locations of this protein?
Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome. Note=Secreted, after cleavage, in the pancreatic juice.
Protein: RPC4_SCHPO
Sequence: MRKFTPKFVPRRKNGPVEEKDVDERVKIEFDVESQKKWKASRPKPEIKLTASGPFALGPNASSSGTGRPIGSVYVPPPNVKNEEKDDALSKLAASSGHDEGHDEDMVDILKLRELNGQEQGKTDIGGKDLLVPIITDRMLPESNDEKLKHHAESAIHTTVINKEDEEQERVALDLQSLAQHLGLTEQEGMEDHFKDQMVLMQFPDKLPRFMGDADVDPVWPSSEVKEEEAGEKTDVEEKKDPDKHGRENGNIDDLTSLPYPAFHPPAGQIGVLRVHQSGKTTLEMGGVNFVVQSGSDCLFLQEIAVVDYDSKRIWNLGSFERRMIVSPDF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Essential for tRNA synthesis.  The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit rpc4, RNA polymerase III subunit C4, RNA polymerase III subunit C53.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TYSY_LEUMM
Sequence: MSQNEQQYLDLAQKILDEGSHKGDRTGTGTRSLFGTQMRFNLAEGFPLLTTKKVFFGLIKSELLWFLRGDNNIRFLLEHNNHIWDEWAFKKWIESDKYTGPDMTNFGLRSQTDENFAKIYKEQKDIFVNNILNDDEFKEEFGYIGNVYGKLWRSWETNSLTAGDETVDQVARLIDQIKETPNSRRLILTAWNAETTPQAPLPSCHVLSQFYVADGKLSLQMYQRSGDFFLGVPFNIASYSLLLHMVAAQTGYEVGEFIHTIGDTHIYNNHVDQITEQLSRPMHKLPKLWLNPEVKSLFDYTMDDIKILDYDSEPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DS22A_DANRE
Sequence: MGNGMNKVIDGLYLGNIRDSENRDSLSRNGITHILSVCNNAKPVLEDMTYLCINAADASSQNLSQHFKESIRFIHECRLNGGACLVHCLAGVSRSTTVVVAYLMTVTSYGWQECLTAVKAVRSFVGPNYGFQQQLQEFQMKQVSEYQAWLRASYRSSPFKDQEQVEALLSLFAEQQQQGQQNDPEWMSQGSRIYPLSYNQYSASGSNR
What is the function of this protein?
Activates the Jnk signaling pathway.  Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase 22-A.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1137_PECAS
Sequence: MPSFDIVSEIDMQEVRNAVENATRDLSTRWDFRNVPASFELNEKSQSIKVASESDFQVQQLVDILREKLVKRGIEGGALEIPEEMEHSGKTYSVEAKLKQGIETTLAKQLIKLIKDSKLKVQAQIQGEQVRVTGKARDDLQGVMALIRGGNLGQPFQFTNFRD
What are the official names of this protein?
UPF0234 protein ECA1137.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: ACEK_BURVG
Sequence: MNHFPKLLSSQIGFDIAQTMLEYFDRHYRIFREAAVEAKTLYERGDWHGLQRLARERITSYDERVKECVELLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFNNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLAATLERIVTNFQLEPPFEDLTRDIGCVMQAIDDEFGQFDAAPDFQIHVLSSLFFRNKSAYIIGRIINADRVLPFAMPIRHVRAGVLAVDTVLLRRELLQVIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLSRLDHALVRELEKEVPSLLEHEDDNLVIEHLYIERRMTPLNLYLQNGSDADIEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPAPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRTVFMKHHADFFDPALWQASKDKLLQGELPDFYPYDTSLRFCVRYAARFDATPDHDDGAGAAQRAA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_PSEA6
Sequence: MPELPEVEVSRLGISPHLIGQHIEQIIVRHKQLRWWVPDDVHLAEGHKVNDVRRRAKYLFIDTDAGSIILHLGMSGKLRIVNSETPVIKHDHIDIVLTNGVCLRFNDARRFGACLWQRVGDPEIGMIAALGPEPLTSDFDGQRLYDLSRTKNVPVKNFIMDNKVVVGVGNIYANESLFIAGIDPRKAAKKVSKKSYLALGDIIKQVLAKAIEQGGTTLKDFTQADGNPGYFAQHLRVYGRKGQACEVCESEIQSVTLGQRNTFFCEQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: HTPX_SHEPC
Sequence: MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKKAMGCEVITMPRDGTERWLVETVARQAQQAGIKMPEVAIYQSPEMNAFATGPSKDNSLVAVSTGLLYGMSQDEVEAVLAHEVSHVANGDMVTLTLIQGVVNTFVIFAARVVAGIINNVVSSNDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYRADEGAARLAGKHKMIAALERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALQAR
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.