PharMolix/UniProtQA huggingface dataset:
Protein: KEFC_ENT38
Sequence: MDSHTLIQALIYLGAAALIVPVAVRLGLGSVLGYLIAGCIIGPWGFRLVTDAESILHFAEIGVVLMLFVIGLELDPRRLWKLRASVFGGGALQMIACGALLGGFCILLGMDWKVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSTFSVLLFQDIAAIPLVAMIPLLAVSGSSTTLGAFALSALKVAGALALVILLGRYVTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEAGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSVDFGTLVTHPLRILILLVGFLVIKMGMLWLIARPLNVPNRQRRWFAVLLGQGSEFAFVVFGAAQMANVLDPEWAKALTLAVALSMAVTPILLVLLTRLEQSGSEQDREADEIDEEQPRVIIAGFGRFGQISGRLLLSSGVKMVILDHDPDHIETLRKFGMKVFYGDATRVDLLESAGAAKAEVLINAIDDPLTNLQLAELAKEHFPNLKIISRARDVDHYIKLRQAGVETPERETFEGALKTGRMALEGLGLGAYEARERADLFRRFNLDMVEEMVEMADGDASSRAAAVKRTSAMLTEIINEDRNHLSLTQRHGWQGTEEGKHTGDPRDEPESKPTV
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y353_MYCGE
Sequence: MEKTSNTSKPLSRSEINKIIAVATGIKEKKIKEIFKYLNTLLLNELVSRSVCILPENLGKLRITIRNARYQKDMQTGEIRHIPPKPLVRYSPSKTIKETAAKVRWKYAD
What are the official names of this protein?
Uncharacterized protein MG353.
Protein: HSCB_VIBCM
Sequence: MNYFELFGLPIQFELDGSLLSSQFRALQKRFHPDNFATASERDRLMAVQQAAQINDAYQTLKDSLRRAEYLLSLQGIEMKAEQQTLQDPMFLMEQMELREELESVTACADPEAALVAFDTKVTAMQRHYLAQLQGQLAQSEWLAAADQIRKLKFIAKLKNEVERVEDQLLG
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: CASQ1_HUMAN
Sequence: MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
What is the function of this protein?
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244).  Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits.  Can bind around 80 Ca(2+) ions (PubMed:28895244).  Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.  Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316).
What are the official names of this protein?
Calsequestrin-1, Calmitine, Calsequestrin, skeletal muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the calsequestrin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316).
Protein: P4KA2_ARATH
Sequence: MERLNELCDIIEQNPKQFLDKLPWICQQCPQSKLLRAESPRFSQSHLNAILAVTRILSKIVDTTDENAKFVVLDFLQTVPKSFHRSFWPYSLSLESISAFYCSFLGYVSCLSQLMVEGYLLRAAQRSDIFAHTLIWHLQGESVEEIVKDGAFDKNASFQEILSDVRQHIVDGFTPKALNFFSREFDFFEKVTSISGALLPLPKEERVAGIRRELEKIKMQGEDLYLPTAPNKLVRVIQVDSGIPLQSAAKVPIMITFNVVDLDGDHNDVKPQACIFKVGDDCRQDVLALQVISLLGDIFQAVGLNLYLFPYGVLPTVVPNTRSRSQMGETTDGGLYEIFQQNYGLVGSTTFETARANFLISSAGYAVASLLLQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFENAHFKLSHEMTQLLDPSGVMKSKTWHQFVSLCVKGYLAARRYMDEIISTVQMMLESGLPCFSRGDPIGNLRKRFHPEMSEREAALFMINVCTDAYNKWTTAGYDLIQYLQQGVEK
What is the function of this protein?
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
What are the official names of this protein?
Phosphatidylinositol 4-kinase alpha 2, PI4-kinase alpha 2, PtdIns-4-kinase alpha 2, Phosphatidylinositol 4-OH kinase alpha2, AtPI4Kalpha2, PI-4Kalpha2.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNAA_BACC7
Sequence: MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPSKPNSAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REPA1_BUCAI
Sequence: MIIRKCYINNPNPFFTPPKNNKRRPSFICYAMKRASEIDVARCELNYILQIKNIKIGFPVKRFRRLNEHRACAMRAMVLAMLYHFNISSDLVQASVEQLSDECGLSTLSKAGNKSITRASRLITNFMEPMGFVTCKKTWDKILGNYMPKMITLTPLFFMLFGVSEKKLMDAKKQQLGWINKNLISKGFKPITMIDAKRRSKDTQIKNIFQYRISKHAFYKKKRNAQRLISLDEKEARQTILRALVAKYSITELTKLGPNGLKKQVNISYYYLRKIATNTYPDN
What is the function of this protein?
This protein is essential for plasmid replication; it is involved in copy control functions.
What are the official names of this protein?
Probable replication-associated protein repA1.
What is the protein family that this protein belongs to?
Belongs to the IncFII RepA family.
Protein: SSUB2_NOCFA
Sequence: MVRTRELRRGFGDRTVLRGIDLDIARGEFVALLGRSGSGKSTLLRALAELDDAGTGSGELRVPSERAVVFQDSRLLPWARVLDNVILGLSGADAAARGRAALAEVGLAGRERAWPRELSGGEQQRVALARSLVREPELLLADEPFGALDALTRIRMHALLQDLCARHKPAVLLVTHDVDEAVLLADRVLVLQDGRLATDLRIELPRPRRHSAPEFIHARELLLAALGVDLAAPEEEKQAS
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PEPA_PHANO
Sequence: MPSFTYLTAALALTSSVVASPVEKRDAFEVKQVAHGLHRKNGPAQIAKTLRKYGKAVPAHIQAAADNNAVVQADANTGSDPAVPSDQYDSSYLSPVTVGTSTVHLDFDTGSADLWVFSDLQAKSSLSGHDYYKTDASKRKSGYTWKISYGDGSGASGQVYTDKVTVGQVTATAQAVEAATSVSAQFSQDVDTDGLLGLAMSSINTVKPQQQTTWFDTVKSQLAKPLFAVTLKYHAAGTYDFGYIDSAKYTGAITYVNADASQGFWGFTASGYSVGTGATVSSSISGILDTGTTLMYVPAATAKAYYAKVSGAKLDSTQGGYVFPCSATLPNFSITVAGVKQTVPGKYINYAPITDGSSTCFGGMQPDTDIGQSIFGDIFLKSKYIVHDMSNGTPRLGFAQQAGVSS
What is the function of this protein?
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates.  The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site.  Shows a broad primary substrate specificity.  Favors hydrophobic residues at the P1 and P1' positions.
What are the official names of this protein?
Aspartic protease SNP2, Protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NRAM6_ARATH
Sequence: MAAETASGSNRSISNSPLIENSDSNQILVPEKKSWKNFFSYLGPGFLVSIAYIDPGNFETDLQSGAQYKYELLWIILVASCAALVIQSLAANLGVVTGKHLAEHCRAEYSKVPNFMLWVVAEIAVVACDIPEVIGTAFALNMLFNIPVWIGVLLTGLSTLILLALQQYGIRKLEFLIAFLVFTIALCFFVELHYSKPDPKEVLYGLFVPQLKGNGATGLAISLLGAMVMPHNLFLHSALVLSRKIPRSVTGIKEACRYYLIESGLALMVAFLINVSVISVSGAVCNASDLSPEDRASCQDLDLNKASFLLRNVVGKWSSKLFAIALLASGQSSTITGTYAGQYVMQGFLDLRLEPWLRNFLTRCLAIIPSLIVALIGGSAGAGKLIIIASMILSFELPFALVPLLKFTSSKTKMGSHANSLVISSVTWIIGGLIMGINIYYLVSSFIKLLLHSHMNLVAIVFLGVLGFSGIATYLAAISYLVLRKNRESSSTHFLDFSNSQTEETLPREDIANMQLPNRVAVIGDLN
What is the function of this protein?
Probable intracellular cadmium (Cd) transporter that participates in the distribution or availability of Cd within the cell.
What are the official names of this protein?
Metal transporter Nramp6, AtNramp6.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein.
Protein: NDUA9_RAT
Sequence: MAAAVRFQVVRALPMSRPAISAAATSVFCSSSHRQLHHAVIPHGKGGRSSVSGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDIYDTMHLRLMGDLGQLIFLEWDARDKDSIRKAVQHSNVVINLIGREWETRNFDFEDVFVNIPRAIAQASKEAGVERFIHVSHLNASMKSSAKSLRSKAVGEKEVRTVFPDAIIIRPSDMFGREDRFLNHFANYRWFLAVPLVSLGFKTVKQPVYVADVSKGIANATKNPDAIGKTFAFTGPNRYLLFHLVKYIFGMTHRTFIPYPLPRFVYSWIGRLFGLSPFEPWTTKDKVERIHISDVMATDLPGLEDLGVQPTPLELKSIEVLRRHRTYRWLSSEIEETKPAKTVNY
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial, Complex I-39kD, CI-39kD, NADH-ubiquinone oxidoreductase 39 kDa subunit, Sperm flagella protein 3.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA9 subunit family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SAA3_MOUSE
Sequence: MKPSIAIILCILILGVDSQRWVQFMKEAGQGSRDMWRAYSDMKKANWKNSDKYFHARGNYDAARRGPGGAWAAKVISDAREAVQKFTGHGAEDSRADQFANEWGRSGKDPNHFRPAGLPKRY
What is the function of this protein?
Major acute phase reactant.  Apolipoprotein of the HDL complex.  In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity).
What are the official names of this protein?
Serum amyloid A-3 protein.
What is the protein family that this protein belongs to?
Belongs to the SAA family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_SHESW
Sequence: MTNVLLVALGGSIGAVFRYLISIFMIQVFGSSFPFGTLVVNVIGSFFMGVIYALGQMSHISPELKALIGVGLLGALTTFSTFSNETLLLLQEGDWLKAILNVVLNLSLCLFMVYLGQQLVFSRI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPB_BURM9
Sequence: MPSAPDAPAAPDAAASVAPNPPAALPVTVRWLGETPYDACFDAMRAFTDARTPDTDDEIWVVEHPPVYTLGQAGNPAHLLVADSGVPLVKVDRGGQITYHGPGQIVAYLLVDLRRRKLMVRTLVTRIEEAVIETLAAYNLASARKAGAPGIYVESGPHRGAKIAALGLKIRNGCSYHGLSVNVKMDLRPFLAINPCGYAGLETIDMASLGATADWHEVAQTLVRRLIAHLDGATAAAALPQQALEQSND
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_BURO1
Sequence: MTKSELVAQLASRFPQLVLKDADFAVKTMLDAMSDALAKGHRIEIRGFGSFGLNRRPARVGRNPKSGEKVQVPEKFVPHFKPGKELRERVDGRAGEPLKADDPDDDR
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL7_SACEN
Sequence: MAKLSNEELLDVFKEMTLLELSSFLKEFEETFDVTAAAPVAAAAPAAAGAAAPAAEEQDEFDVVLESAGDKKIQVIKVVREIVSGLGLKEAKELVEGAPKPILEKVDKEKANEAKTKLEESGAKVSLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ARLY_CITBB
Sequence: MSKDKLWGGRFTQPTDKFVEEFTASINFDKRLYHQDIRGSIAHATMLGKQGIIPVADVESIVSGLKTILEQIEAGEFDFSVSLEDIHMNIEARLSEKIGDAGKRLHTGRSRNDQVALDIRLYLRDELVEVSAYIDLLIDAIIHQAEENLGVIMPGFTHLQTAQPILFSHHMMAYHEMLKRDKARMEDCLKRTNVLPLGAGALAGTTFPIDREYVAELLDFDGVTRNSLDSVSDRDFAMEFCAASSILMVHLSRFSEELILWSTSEFKFVELSDSFCTGSSIMPQKKNPDVPELVRGKTGRVNGNLVALLTLMKSLPLAYNKDMQEDKEPLFDTIDTVKGCLKVFADMVREMKINPERMKTAAAAGFSTATDVADYLVRKGIPFRDAHEIVGKTVRYCIENEMDIPELSLAEWQLFSGRIEEDIFESITLQASVNARRATGGTALERVRAEIARAKEGR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS29_HUMAN
Sequence: MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688).
What are the official names of this protein?
40S ribosomal protein S29, Small ribosomal subunit protein uS14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: GNAS2_MOUSE
Sequence: MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).  Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP.  GNAS functions downstream of several GPCRs, including beta-adrenergic receptors.  Stimulates the Ras signaling pathway via RAPGEF2.
What are the official names of this protein?
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Adenylate cyclase-stimulating G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(s) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: HFQ_KLEP3
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGSSNYHHGGSAQGSSAPQQDSDDAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: GK_HHV1R
Sequence: MLAVRSLQHLSTVVLITAYGLVLVWYTVFGASPLHRCIYAVRPTGTNNDTALVWMKMNQTLLFLGAPTHPPNGGWRNHAHICYANLIAGRVVPFQVPPDAMNRRIMNVHEAVNCLETLWYTRVRLVVVGWFLYLAFVALHQRRCMFGVVSPAHKMVAPATYLLNYAGRIVSSVFLQYPYTKITRLLCELSVQRQNLVQLFETDPVTFLYHRPAIGVIVGCELMLRFVAVGLIVGTAFISRGACAITYPLFLTITTWCFVSTIGLTELYCILRRGPAPKNADKAAAPGRSKGLSGVCGRCCSIILSGIAVRLCYIAVVAGVVLVALHYEQEIQRRLFDV
What is the function of this protein?
Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.  Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation).  Seems to block fusion of virions with infected-cell membranes (By similarity).
What are the official names of this protein?
Envelope glycoprotein K, Syncytial protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein K family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Probably not present in extracellular virions (By similarity).
Protein: IF2_RALSO
Sequence: MASTTVAQLAGELNRSAAALLEQLQAAGVQKATPEDVITESDKTRLLDYLKRAHGSAEDGARKKITLTKRETSEIRQADATGKTRTVQVEVRKKRVLMKRDEAGAAPAEAEAPAPVTAPVVDVEEVARREEEQRRQAELLARQEAELKARQEAMEREEAERRARQEAAEAEQRRQAELAAKKAEEEAAAARAAAEASDEAPRRKAEEDAARLASEREAAQKAAEEARAAADKIKAEEDGARKRREAAEAEARAIREMMNAPARVLKTPAERKAEEKKAEQSGTLHKPVKAAGEARPAPAAKKAAAPAAAPAATPAGDKKGGRGGKPGGWQDDARGNKRGGLKTRGDTGGGVDGWRGSKGGRNRHGDDNRNAFQAPTEPVVREVHVPETISVAELAHKMAVKAAEVIKQMMKLGQMVTINQVLDQETAMIVVEEMGHQAVAAKLDDPEALLVEGVQEQQNVEAEARPPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETPRGVITFLDTPGHEAFTAMRARGAKATDIVILVVAADDGVMPQTKEAIAHAKAAGVPIVVAINKIDKPEANPDRVKQELVSESVIPEEYGGDSPFVPVSAKTGQGIENLLENVLLQAEVLELKAPINAAAKGLVVEAQLDKGKGPIATVLVQSGTLKRGDVVLAGTAYGRVRAMLDENGKPAKEAGPSIPVEIQGLSEVPGAGEEVIVLPDERKAREIALFRQGKFRDVKLARQQAAKLETMLEQMSEGEVKTLPLIIKADVQGSQEALVHALNKLSTGEVRVQVVHGAVGGISESDVNLATASKAVIIGFNTRADAGARKLAEHQGIDIRYYNIIYDAVDEVKAAMSGMLSPEKKEETTGLVEVRQVFHVPKVGAVAGCMVLDGVVKRSSLVRVLRENVVIFSGELESLKRFKDDVKEVKQGFECGLSIKNFNDVKEGDQLEIYEITEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTJ_ASPOR
Sequence: MSRRFPIQVAQSEIPPIAWGLWRMVYRLWLHPLSGYPGPRLAAVSNLPYFAWTCTGNLHLRLQELHKVYGDVIRIRPNALTYRTPEAWTDIYGHRKPGTLPFSKDPEFFMPAQAGSSHMINANEKDHTRQKRLLNHAFSERSLRQQEHLIMGYIDLFIQRLRGQARMGAETVNMEEWLNFLTFDIIGDLAFGEPFGCLQNSEYHPWVATIFKSIKTGAILRALNIYPILLGFIRRFLPKSLVQKRIAHYQMSKDRVTRRLQTETSRPDFISYILKYNDDRGMSTPEIEMNAALLIQAGSETTATVLAACLYFLQKNAACHRRLVQDIRSAFTQETDINFLSAAQLPYMNGVIEESLRLFPPAPGIGPRVVPKGGARICGRYVPGGVSVSVGHYSTFRSARNFTRPNEFLPQRWLDRDAESEFASDQTMALQPFSYGPRACIGRNLAYAEMRTILAKILWHFDVQLDERSADWANSKSYIVWEKGPLWLKLHPRNVPQETD
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities (PubMed:27628599).  The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate (PubMed:27628599).  Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK (PubMed:27628599).  Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE (PubMed:27628599).  The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin (PubMed:27628599).  The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively (PubMed:27628599).  Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B (PubMed:27628599).
What are the official names of this protein?
Cytochrome P450 monooxygenase astJ, Astellolide biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: TGS1_RAT
Sequence: MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDRVTEEEEDDHSSGTTESHSADEGDLDPEAKLMRSMGLPVRFGRMSTHGSFEVSMNARNKAKVRQKRRKHRKQYLDEIVREDWRNDCEEDDLVVSDDPSSVEHCENNSACEIQSKTDAEAENLPVENTLAPKLEVTENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFVASQNCDKDVCTSHTQVDQNAESSLKADGTTLSSSPNTAEDESLGSNDNDHNEIIAGINKITLSAEEVEQSQLDSSEHCDKPLSEVTGKECPASGGSDSCHGTPKESDISENRSSDQPAQELQESSGTNTSKHRPHHNGTDGNESEDDPPDHKPSKMKRSHELDIDENPDSEVDDNGFHLGFKHGSGQKYGGIPNFSRRQVRYLEKNVKYKSKYLDMRKRMTVKNKHIVFSEESGKPFIRKSKVRSKVEKFLKWVNEPVDEEISQEPLSHNKMQDTCTSSDSEEQDMSMEKTDGLMETRDPEPENCQTISSASELEAEKSEGGSLVAAVPENCSTEGVANSPRAEAEVEIKKKKKKKKKNKNKKINGLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQSFNCDIIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGVADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADVDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPALRSAEA
What is the function of this protein?
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure.  The enzyme is specific for guanine, and N7 methylation must precede N2 methylation.  Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs).  Plays a role in transcriptional regulation (By similarity).
What are the official names of this protein?
Trimethylguanosine synthase, Nuclear receptor coactivator 6-interacting protein, PRIP-interacting protein with methyltransferase motif, PIMT, PIPMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.