PharMolix/UniProtQA huggingface dataset:
Protein: EMP2_HUMAN
Sequence: MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK
What is the function of this protein?
Functions as a key regulator of cell membrane composition by regulating protein surface expression.  Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.  Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity).  Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193).  Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity).  Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity).  Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233).  Also regulates many processes through PTK2.  Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602).  Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127).  Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199).  Positively regulates cell proliferation (PubMed:24814193).  Plays a role during cell death and cell blebbing (PubMed:12107182).  Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331).  Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956).  Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity).  Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity).  May play a role in glomerular filtration (By similarity).
What are the official names of this protein?
Epithelial membrane protein 2, EMP-2, Protein XMP.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
Protein: UGT48_CAEEL
Sequence: MLLRILTFLAVCQVTTSHKILMFSPTASKSHMISQGRIADELANAGHEVVNFEPDFLNLTDKFVPCKKCRRWPVTGLNNYKFKKIQNGLSGDVFQQSSIWSKIFNTDSDPYQDEYTNMCEEMVTNKELIEKLKKEKFDAYFGEQIHLCGMGLAHLIGIKHRFWIASCTMSVSMRDSLGIPTPSSLIPFMSTLDATPAPFWQRAKNFVLQMAHIRDEYRDVVLTNDMFKKNFGSDFPCVEFLAKTSDLIFVSTDELLEIQAPTLSNVVHIGGLGLSSEGGGLDEKFVKIMEKGKGVILFSLGTIANTTNLPPTIMENLMKITQKFKDYEFIIKVDKFDRRSFDLAEGLSNVLVVDWVPQTAVLAHPRLKAFITHAGYNSLMESAYAGVPVILIPFMFDQPRNGRSVERKGWGILRDRFQLIKDPDAIEGAIKEILVNPTYQEKANRLKKLMRSKPQSASERLVKMTNWVLENDGVEELQYEGKHMDFFTFYNLDIIITAASIPVLIFIVLRISNISIITSSPKNKKD
What are the official names of this protein?
Putative UDP-glucuronosyltransferase ugt-48, UDPGT 48.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SSL10_STAAE
Sequence: MKFTALAKATLALGILTTGTLTTEVHSGHAKQNQKSVNKHDKEALYRYYTGKTMEMKNISALKHGKNNLRFKFRGIKIQVLLPGNDKSKFQQRSYEGLDVFFVQEKRDKHDIFYTVGGVIQNNKTSGVVSAPILNISKEKGEDAFVKGYPYYIKKEKITLKELDYKLRKHLIEKYGLYKTISKDGRVKISLKDGSFYNLDLRSKLKFKYMGEVIESKQIKDIEVNLK
What is the function of this protein?
Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction.  Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12.  Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin.  Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration.
What are the official names of this protein?
Staphylococcal superantigen-like 10.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNPH_METS4
Sequence: MRPSKRAPDELRKVTLEKGVARYAEGSCLVTFGETKVLCTASLEERGPPWLRGSGKGWVTAEYAMLPRATHERNRREVTAGKPSGRTQEIQRLIGRSLRAVVNLPAIGERQIVVDCDVLQADGGTRTASITGAWVALHECFTWMRGRSIISVDPMRDHVAAISCGIHKGIPILDLDYDEDSAADTDANFVITGSGGIVEVQGTAEIAPFSEEQFLGLLRLAKAGVAQLVALQKQAVG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: SR140_HUMAN
Sequence: MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESARESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH
What are the official names of this protein?
U2 snRNP-associated SURP motif-containing protein, 140 kDa Ser/Arg-rich domain protein, U2-associated protein SR140.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
Protein: CCDC6_MOUSE
Sequence: MADSASESDTDAAGGGPAAMQSSCSATSGGSGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGASHGITRPSPRRSSSPDKFKRPTPPPSPNTQSPVQPPPPPPPPPMQPAVPSAAPTQPAPTQPQHPVHPSSQP
What are the official names of this protein?
Coiled-coil domain-containing protein 6.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=May be a cytoskeletal protein.
Protein: SSUD_BURTA
Sequence: MNVFWFIPTHGDSRYLGTAEGARAADYDYFRQVAVAADTLGYDGVLLPTGRSCEDAWVVASSLIPATKRLKFLVAIRPGLSSPGLSARMASTFDRLSGGRLLINVVTGGDSAELEGDGLFADHDTRYALTDDFLHIWRKLLAESHENGSVDFDGEHLRAKGGKLLYPPIQHPHPPLWFGGSSPAAHAIAADHIETYLTWGEPPAAVAKKIADIRARAAERGREIRFGIRLHVIVRETEEEAWRDADRLISRLDDDTIARAQQAFAKMDSEGQRRMAALHGGKRGSRQELEIYPNLWAGVGLVRGGAGTALVGNPEQVAARMREYAALGIETFILSGYPHLEESYRFAELVFPLVKGGDARRAGPLSGPFGEVVGNGYLPKVSQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: STAR_HORSE
Sequence: MLLATFKLCAGSSYRHVRNMKGLRHQAALAIGQELNWRAPGGPTQSGWINQVRRQSSLLGSQLEDTLYSDQELAYIQQGEEAMQKALGILRNQEGWKEENQQANGDKVLSKVVPDVGKVFRLEVEVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAESAGNLVGPRDFVSVRCAKRRGSTCVLAGMATQFEEMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESSPAPEARC
What is the function of this protein?
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone.  Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
What are the official names of this protein?
Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AMYR_DROME
Sequence: MFKFALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNENILSAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVGTAGTEAEPSKKSFPGVPYTAQDFHPTCEITDWNDRFQVQQCELVGLKDLDQSSDWVRSKLIEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHETVSRDEYKDLGAVTEFRFSEEIGNAFRGNNALKWLQSWGTDWGFLPSGQALTFVDNHDNQRDAGAVLNYKSPRQYKMATAFHLAYPYGISRVMSSFAFDDHDTPPPQDAQERIISPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYDLSQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV
What are the official names of this protein?
Alpha-amylase-related protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAR_COMTE
Sequence: MKLQTLQALICIEEVGSLRAAAQLLHLSQPALSAAIQQLEDELKAPLLVRTKRGVSLTSFGQAFMKHARLIVTESRRAQEEIGQLRGRWEGHITFAASPAIALAALPLALASFAREFPDVTVNVRDGMYPAVSPQLRDGTLDFALTAAHKHDIDTDLEAQPLYVSDVVIVGQRQHPMANATRLAELQECRWAFSSAPRGPGAIIRNAFARYGLPEPKLGLVCESFLALPGVVAHSDLLTTMPRTLYERNAFKDQLCSIPLQDALPNPTIYVLRRHDLPVTPAAAGLIRWIQHHALQTG
What is the function of this protein?
Regulates expression of the tsaMBCD1 operon and of tsaT in response to p-toluenesulfonate (TSA).  Acts by binding directly to the promoter region.  Binding to the tsa promoter depends on TSA concentration.
What are the official names of this protein?
HTH-type transcriptional regulator TsaR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: HSLO_VIBVY
Sequence: MASNVLNRYLFEDLSVRGELVQLDEAYQRIISSKDYPAALQKLLGELLVSTTLLTATLKFEGSITIQLQGDGPVSLAVINGDNEQKIRGVARWEGHIADDATLHDMMGKGYMVITIEPKKGERYQGIVGLEGDNLEQVLEGYFERSEQLKTRIWIRTGEHEGKAHAAGMLIQVMPDGTGSENDFEHLEQLTNTVKNEELFTLPANELLYRLYNQEQVRLFEPQNVEFRCGCSRERSGAAIVTVDKNEIYDILASDGSVSLHCDYCGTTYSFDESDVNKLYEEAASEPKTLH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_CERS1
Sequence: MPLELVTVPCLSDNYAFLVHDAGTGETSVVDVPEAGPVLKALEERGWHLSQILLTHHHSDHVAGVEELRAATGARVAGAAADAHRLPPLDLELAEGDLVRVGASEGRVIEVPGHTVGHIAFHFPDSSLAFTGDSLMAMGCGRLFEGTAEAMWQSLRKLSALPPETMICSGHEYAASNARFAATLEPDSPMLIFRVGSIAAARKEGRPTVPSHLSDEIATNPFLRAGEASLKAAVGMVDAEDAEVFAEIRRRKDKF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: ASGX_PYRFU
Sequence: MVAIIVHGGAGTIRKEERIPKIIEGVREAVLTGWRELKKGSALDAVEEAVKVLEDNPLFNAGTGSVLTLDGKVEMDAAIMRGKTLDAGAVAGIWGVKNPISVARKVMEKTDHVLLIGEGAVKFARLMGFPEYDPTTEERRKQWEELRKKLLETGEIRHWKKLSELIKEYPEVLRSTVGAVAFDGEEIVAGTSTGGVFLKMFGRVGDTPIIGAGTYANEVAGASCTGLGEVAIKLSLAKTATDFVRLGLDAQAASEAAIRLATKYFGPDTMGIIMVDSNGNVGFAKNTKHMSYAFMKEGMKEPEAGV
What are the official names of this protein?
Putative L-asparaginase, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Ntn-hydrolase family.
Protein: CYVUA_VIOPU
Sequence: GVIPCGESCVFIPCISAVIGCSCKSKVCYRN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide vpub-A.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: GREA_CLOB8
Sequence: MSQSKQYVMTYEGVKKLESELEYLKTVKRKEITEKIKIALGYGDLSENSEYDEAKNDQAFTEGRIIQLENMLKNAVVVDESEIPSDIVSVGSKVKVKDYEFDEEVEYSIVGSAEADPMNFKISNESPVGNALVGKKVGDVVEVTVPDGVNKFEILGISRS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: GLPB_GLAP5
Sequence: MNFDVVIIGGGLAGLTCGVALQEQGKRCVIINNGQAAIDFSSGSMDLLSRLPSGEFVADFYKSYATFAKQLPQHPYSLLGKEKVLAKATQFEQLATSLKLDLVGSTAQNHLRVTPLGGLRGAWLSPNSVPTVKGSEPFPHKTIAILGIEGYHDFQPQLLADNLKQNPQFTHCELSTGYLNIPELDQLRNNAREFRSVNIAQVLEHKLAFRDLVAEIKTATKGAEAIFLPACFGLDDQSFFNQLQQAVEATIFELPTLPPSLLGIRQHKQLRHRFERLGGLMLNGDRALKADIENGKVQRIYTQLHQDNAISAEHLVLATGSYFSNGLKADFDRIFEPVFQADIVGCKDFNETDRLSWTANRFSSPQPYQSAGVAINEKCQVRKDGQFMANLYATGNVIGGFNSLELGCGSGVAVVTALAVAEEIVGA
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: AROC_KOCRD
Sequence: MLRWLTAGESHGEALVGIVEGVPAGVELTTGMVQDALARRRLGYGRGARMKFEQDRVRILGGVRHGLTQGGPVAIEIANTEWPKWQDVMSSDPVDPQVLEGRARNAPLTRPRPGHADLTGMQKYGFDEARPVLERASARETATRVALGVVASQILAALGVRLVSHTTAVAEVAVPEGAPLPGPQDVPALDADPLRCFDAETSAAMVAAVDAAHKAGETLGGVVEVLAEGMPPGLGSYVHWDRRLDSRLAGALMGIQAIKGVEVGDGFRTAQRPGSLAHDETLRADGSVHRVSNRAGGIEGGMSTGDLLRVRAAMKPIATVPRSLHTVDVATGEPARAHHQRSDVCAVPAAGVVAEAMVALVLAEAALEKFGGDSVAELVRNRDSYLAGIPESLRTSPELADPAALAALDEVRGDLS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS15_GEODF
Sequence: MLATDKKQEIIGAYKLHDSDTGSPEVQIAILTERITYLTEHFKTHKKDHHSRRGLLKIVGQRRGLLDYLKKKDVERYRSIIEKLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: AROB_PYRNV
Sequence: MRRFFYRHSRGVTEVVVGSGLQYGDYVERPVVLAEEGLRPPIPGAPTLALRGGEEVKSLEVLTKVYGFLKEVGADRSTTLVAVGGGALLDLATFAAGTYMRGIRLVHIPTTLLAMVDAALGGKGAVDWGPVKNLIGVFYQPAAILCDLSWLGTLPERVYRSAFAEVVKYGLALDGDFYSWVRENAKALLARDGGALEYAVYRSLQLKAGVVEVDEFEERGVRQVLNVGHTVGHAVERVLGLLHGEAVAVGMVAELRLSSELGYLRESHVAEAAEVLSSLGLPTSVKATEQQLAEAAALVKFDKKRRGGHIYIPLVVRPGRWILEKIAVEEVEKAVRYVLRQGG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAJQ_SALA4
Sequence: MPSFDIVSEVDLQEARNGVDNAVREVESRFDFRGVEATIELNDANKTIKVLSESDFQVNQLLDILRAKLLKRGIEGASLDVPDEFVHSGKTWYVEAKLKQGIESAVQKKIVKLIKDSKLKVQAQIQGEEIRVTGKSRDDLQSVMALVRGGDLGQPFQFKNFRD
What are the official names of this protein?
UPF0234 protein YajQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: AROC_METI4
Sequence: MPNTFGHLFRITTWGESHGKGVGVVIDGCPPRIPLSEEDIQKELDRRRPGQSKITTQRKERDIAAILSGTFNGMTLGTPIMIWVKNEDARPEAYAEMEKIYRPSHADFTYQAKYGIRNWQGGGRSSARETIGRVAGGAVGGKVLQFLYPEIEVIAWVSEVHGLKSLCDPNTVTREDVESNILRWPNAENLGEALKEIERAQKEGDTVGGIVECIVRGMPVGLGEPVFDKLEADLAKAMLSLPASKGFEIGSGFRGALMRGSEHNDPFYMEGNKVRTKTNWSGGVQGGISNGENLYFRVAFKPVATIAQEQQTVSVDGEEVILRARGRHDPCVLPRAVPIVEAMTKLVLVDHALRQKAIELTPRSFS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y7311_DICDI
Sequence: MLFKSIISLSNSSKSLNNKINNDNENNNLEFSSNKTTINPYSVFSYSRPLWNC
What are the official names of this protein?
Putative uncharacterized protein DDB_G0275587.
Protein: EMC7_DANRE
Sequence: MPHIKRLLDVYIALQALFALSWGFSDPEPGPVAASQSNGDRFKIEGRAIVPGVKTQDWISTARVLVEGEEYVGFLKTDGSFAVNDVPSGSYVVEIVSPSFRFEPVRVDITSKGKMRARLVNYIKTSEVIRQPYPLQIRAGGPHTYFMKRETWGWTDFLMNPMVMMMVLPLLIIVLLPKVVNTNDPEMRKEMEQSMNMLNPNPELPDVSEFMTKLFSKGSSKSGGGNKGSRSVATKRR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 7.
What is the protein family that this protein belongs to?
Belongs to the EMC7 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: SECE_SALTY
Sequence: MSANTEAQGSGRGLEAMKWIVVAILLIVAIVGNYLYRDMMLPLRALAVVILIAAAGGVALLTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVSFITGLRF
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRB_ENT38
Sequence: MSKMFKLNSAFRPSGDQPEAIRRLKEGLEDGLAHQTLLGVTGSGKTFTVANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLHLTNGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDLALRVELFDEEVERLSLFDPLTGHVDSVIQRFTVYPKTHYVTPRERIVQAMEDIKVELAERRKVLLENNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEAPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGNYELEKSGEDVVDQVVRPTGLLDPIIEVRPVGTQVDDLLSEIRARAIINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNINGKAILYGDRITASMAKAISETERRREKQHQYNLDNGIVPQGLNKKVVDILALGQGLAKTKAKGRGKSRSPVEADPVELVLTPKALQQKIHELEGLMMQHAQNLEFEEAAQVRDQLHQLRQLFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_AROAE
Sequence: MKFIDEARIEVMAGDGGNGSASFRREKFIPRGGPDGGDGGRGGSIYALADRNLNTLVDYRFTRMHRAQRGENGGNKDCYGKGGEDIVLRMPVGTVITDLETGELVADLDEDGKQAIVARGGKGGLGNLHFKSSVNRAPRKRTMGEEGERRALRLELKVLADVGLLGMPNAGKSTFIRAVSAAKPKVADYPFTTLAPNLGVVRTDQNRSFVIADIPGLIEGAAEGHGLGHQFLRHLQRTRVLLHLVDLAPFDPDADPVRDAKAIVEELRKYDESLYNKPRWLALNKLDLIPEDERAARVAAFLEAYGPVERHFEISALTGDGCRKLVFAIQDFLDAGRAQAEAEKAARTHAEALAAAEAEARVEAAYQARLQALLAEGETGTGDDGRDGNENDPADEQDTNRPNH
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.