PharMolix/UniProtQA huggingface dataset:
Protein: KEAP1_PIG
Sequence: MQPEPRPSGAGAHTQFLPLRSQRPEGAGDTVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCAELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPHFLQMQLQKCEILQSDSRCKDYLVKIFQELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination.  KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes.  In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes.  In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2.  The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity).  The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
What are the official names of this protein?
Kelch-like ECH-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the KEAP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic. In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62.
Protein: DHE2_PORGI
Sequence: MKTQEIMTMLEAKHPGESEFLQAVKEVLLSVEEVYNQHPEFEKNGIIERIVEPDRVFTFRVPWVDDQGKVQVNIGYRVQFNNAIGPYKGGIRFHPSVNLSILKFLGFEQMFKNALTTLPMGGGKGGADFSPKGKSEAEIMRFCQSFMTELWRNIGPDTDIPAGDIGVGGREVGYMFGMYKKLAREHTGTLTGKGFEFGGSRLRPESTGFGAVYFVQNMCKQNGVDYKGKTLAISGFGNVAWGVAQKATELGIKVVTISGPDGYVYDPDGINTPEKFRCMLDLRDSGNDVVSDYVKRFPNAQFFPGKKPWEQKVDFAMPCATQNEMNLEDAKTLHKNGVTLVAETSNMGCTAEASEYYVANKMLFAPGKAVNAGGVSCSGLEMTQNAMHLVWTNEEVDKWLHQIMQDIHEQCVTYGKDGNYIDYVKGANIAGFMKVAKAMVAQGVC
What is the function of this protein?
Probably involved in degradation rather than biosynthesis of glutamate.
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH, Surface-associated protein PGAG1.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Cell surface.
Protein: TRPF_PROA2
Sequence: MTRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIFVEQSPDEINSICERCNLHCAQLHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAGKTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIGSAILAGGLKPENVGRAIRLVSPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RL15_NEIMF
Sequence: MFLNTIQPAVGATHAGRRVGRGIGSGLGKTGGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFKSLTASANAQLRLSELESIAVNEIDILVLKQAGLIASTVSNVKVIASGEISKAVALKGIKVTKGARAAIEAVGGKIEM
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL11_HAEI8
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNARTESLEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKVTLDQVRQIAETKAADMTGATIETKMKSIAGTARSMGLVVEE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PKHF1_RAT
Sequence: MVDHLANTEINSQRIAAVENCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLSKRKYRSQHIIPLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECVRRQLLATGRQPTTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPRLSPKPLRVCSLCYRELAAQKRREEAKERFRGSPGQLTHLGSTMCGASSGDDDDSDEDREGSGDGDWPTQVEFYASGVSWSAFHS
What is the function of this protein?
May induce apoptosis through the lysosomal-mitochondrial pathway.  Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm.  Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family F member 1, PH domain-containing family F member 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.
Protein: RPOB_BARBK
Sequence: MAQTLAMMSQFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMIKEPKGGRPDEGLQAVFKSVFPISDFSGTAMLEFVRYEFDAPKFDVEECRQRDLTYAAPLKVILRLIVFDIDEDTGSKDIKDIKEQGVYMGDMPLMTSNGTFIINGTERVIVSQMHRSPGVFFDHDKGKSHSSGKVLFAARVIPYRGSWLDIEFDAKDIVYARIDRRRKIPVTSFLMALGMDASDILSTFYNKVTYERVESGWRIPYSVDRFKGVKLVSDLVDAESGEVVAEAGKKLTARTAKLLVEKGLKAIRVSEDELLGSYLADDIVNYETGEIYLEAGDEIDEKVLKVLFDVGANQINILDIDHMSVGAYIRNTLKVDKNESRQDALFDIYRVMRPGEPPTIDTAEAMFHSLFFDSERYDLSAVGRVKMNLRMGLDCPDTVRVLRQEDIIGVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSVEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKITDGKVTTEVVYLSAMEEAKHYVAQANSSLDSEGRFTEEFVVCRHAGEVLMVPRDHIDLMDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLIRSEAPFVGTGMEAIVARDSGAAISAKRGGIVDQVDATRIVIRATEDLDPSKSGVDIYRLQKFQRSNQSTCINQRPLVHVGDRIEKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSERIVADDVFTSIHIEEFEVAARDMKLGPEEITRDIPNVAEEALRNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTFGTVVEVRVFNRHGVEKDERAMEIEREEIERLAKDRDDEQSILDRNVYARLAGMLKDKSAIRGPKGFEKGQKIDSTVLNNYPRSQWWQFAVDDEKVQNKIEALCNQYDESKEALQRRFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGDLVDFYQETGDILPLRQRIENLIPDNDRNEPVRQYDDESLVKLAHQMRKGVSIATPVFDGAHEADINAMLEDAGLDSSGQVTLYDGRTGEPFDRQVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEASIPESFNVLIKEMRSLGLNVKLGDAREFMAQQALPEVVEN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RUVA_BORT9
Sequence: MINKICGKIVEKRESSIVIVALPFEFEILVSSFCNAELGLQEDVEILTYLHLREDEIRLFGFLNVSEREVFEKLISVDGIGPKAALRILSGIKYNEFRDAVEREDVKLISNVKGIGNKMAGKIFLKLRGKLVKVNEASSGVLKFKELEQSIVNMGFDRKLVAAAIKEIMLIDEFLMLRQVDQEQFLFREILRKLSG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ARGJ_YEAS2
Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RAPA_PECAS
Sequence: MPFTLGQRWISDTESELGLGTVVAVNTRMITLLFPASGENRLYSRSDAPITRVMFNPGDTVTSHEGWQLKIDDVREEKGLLVYCGQRLDDETPAELREVFLDSKLTFNKPQDRLFAGQIDRMDRFALRYRARKHQNEQALQQWGGLRGMRASLIPHQLHIAYEVGQRHAPRVLLADEVGLGKTIEAGMIIHQQLLAGRASRVLIVVPETLQHQWLVEMLRRFNLLFSLFDDERYAEAKLDSSNPFETEQLVICSLGFVQRSAQRFAQLVNTDWDLLVVDEAHHLVWSEESPSPEYQAIEALARATPAVLLLTATPEQLGQQSHFARLRLLDPNRFHDYQEFVAEQQQYRPVADAVTLLLAGEKAQAAELNVLSDLLGEQDIEPLLKSINSDSDDNQKARQELITMLMDRHGTSRVLFRNTRQGVKGFPQRVLHQIRLPLPAQYQTAIKVSGIMNANKPLETRARDMLYPEQIYQQLEGDDATWWNFDPRVEWLLNYLTTNRDEKVLVICAQAATALQLEQVLRTREAIRAAVFHEGLSILERDRAAAYFASEEEGAQVLICSEIGSEGRNFQFASHLVMFDLPFNPDLLEQRIGRLDRIGQAKEIQVLVPYLENTAQALLVRWYHEGLDAFEHTCPTGRTIYDAHHAQLIERLTTVGEQQGLDEFIHTCRQQHDSLKQQLEQGRDRLLEMHSNGGEQAQLLAQAIAEQDNDVNLVTFALNLFDIVGINQEDRSDNLIILTPSDHMLVPDFPGLPQDGCTITFDRDQALSREDAQFISWEHPLIRNGLDLVLSGDTGSCAVSLLKNKALPVGTLLAELVYVVEAQAPKHLQLTRFLPPTPVRLLMDRKGTNLAAQVEFESFNRQLNAVNRHTSSKLVNAVQSDVHAMLQQAEALVETQARQLITEAQQQADLQLRRELERLEALKAVNPNIREDELTALENQREQVLSNLHEANWRLDAIRLVVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: ENO_ANAMM
Sequence: MGVRAVVLSARSVAKINRVVARQILDSRGRPTVEVEVLLSDGAVGRVSVPSGASVGKFEAVELRDGDQAKYAGHGVLKPVQRVNTTVADSLAGVSPFDQRAVDEILLSLDGTKNKSKLGANATIGVSLAVAKAAADSVGIPLYKYLGGAVAREMPLPLVNVINGGLHADNLLDFQEFMIVPVGAKTFADAAQICAEVFYKLKEVLKKMGHSTNTGDEGGFAPNLENNTDVLDVLVEAIEKSGYRASSDVALAMDVAASTFYDGTSYKFSGKCLTSGELIACYEDMVSRYPIISIEDAMAESDIEGWKAVTKRLGDKIQLVGDDLFVTNPALIANGVENKLANAVLVKPNQIGTLTETIDAIRSAQRNNYNVIISHRSGETEDVTIAHIAVAANCGQIKSGSFSRSERLAKYNELLRIEEDLGKSALLYNVI
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RNPA_STRGG
Sequence: MLPTENRLRRREDFATAVRRGRRAGRPLLVVHLRSGDTDPHVTGETVPPPRAGFVVSKAVGGAVVRTAVKRRLRHLVRDRLAQLPPGSLVVVRALPGAGDADHAQLARDLDAALQRLLGGGAR
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: CDII_ECOL5
Sequence: MITLRKLIGNINMTKEPEQQSPLELWFERIIDVPLEKLTVEDLCRAIRQNLCIDQLMPRVLEVLTKEPLAGEYYDGELIAALSTIKGEDLKDQKSTFTQIRQLINQLEPSDINDDLRKDILKINQIIV
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Protects cells against the tRNA nuclease activity of CdiA, its cognate toxin protein, but not against CdiA from E. coli strain EC93 or D. dadantii strain 3937.  Binding to CdiA-CT in the CdiA-CysK complex probably blocks the tRNA-binding site of CdiA-CT (PubMed:27531961).
What are the official names of this protein?
Immunity protein CdiI.
Protein: BCL8_HUMAN
Sequence: MSCCLSSRVHITRPVLEQFLSFAKYLDGLSHGVPLLKQLCDHILFINPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTICRIGTVIKDNAHLKILLLGY
What are the official names of this protein?
Putative protein BCL8, Neurobeachin pseudogene 1.
Protein: BIOB_BORPE
Sequence: MHTAYVPVPAPVRPPSAERWPLAAVAELFELPFLDLLHRAQQVHRQHFDANTVQLSSLLSIKTGGCPEDCAYCPQSAHYDTGVDADKLMPLDEVVRAARAAQANGAQRFCMGAAWRSPKPHHLEAVAEMIGAVKALGMETCVTLGMLRDGQAEQLKAAGLDYYNHNLDTAPEFYGKIISTRTYQDRLDTLQQVREAGINVCCGGIVGMGESRRDRAGLVAQLTNMEPYPESVPINNLVQVEGTPLAGAETLDPFEFIRTIAVARITMPLAKVRLSAGRETMSDSEQALCFMAGANSIFYGDVLLTTGNPQVEADRRLLQRLGMRAEGLPCAAGQA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RISB_AGRFC
Sequence: MSKPHLLIVEARFYDDMADALLEGAKFALEEAGATYDVITVPGALEIPAAIAMALDGADNDGTEYDGFVALGMVIRGETYHFDIVSNESSRALMDLAVSESLPIGNGILTVENDEQAWARVRRSDKDKGGFAARAALTMIELKKKLGG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: Y2453_VIBCM
Sequence: MRLIVVSGQSGAGKSVALRVLEDLGYYCVDNLPVSLLTAFIQSVQGSQQNVAVSIDIRNLPKEPSLVQDVLDQLKQNNDVSMLFLDASKETLLKRYSETRRIHPLSLSQSKPSLAQAIELEKQLLGPLKEQADLLLDSSNQSLHELSETVRMRIEGRERKDLVMVFQSFGFKYGLPTDADYVFDVRFLPNPHWEPDLRPLTGLDAPIKSFLEGHSEVMELKQQIQKFFEYWLPMLEKNNRSYLTIAIGCTGGKHRSVYLTQQLGEYFAQLGHQVQIRHTSLEKQQS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein VCM66_2453.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RPOA_PHOV8
Sequence: MAILAFQKPDKVLMLEADSRFGKFEFRPLEPGFGITVGNALRRILLSSLEGFAINTIKIEGVEHEFASVPGVKEDVTNIILNLKQVRFKQVVEEFENEKVSITVENSSEFKAGDISKYLTGFEVLNPELVICHLDSKATMQMDITINKGRGYVPADENREYCTDVNVIPIDSIYTPIRNVKYQVENFRVEQKTDYEKLVLEITTDGSIHPKEALKEAAKILIYHFMLFSDEKITLETSDVDGNEEFDEEVLHMRQLLKTKLVDMDLSVRALNCLKAADVETLGDLVQFNKTDLLKFRNFGKKSLTELDDLLEGLNLSFGTDISKYKLDKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y2151_THEKO
Sequence: MKSFLTEQQIRVLQLRAKGLKQSEIAEILGTSRANVSILERRALEKIEKARNTLLLWEQINSKISVEVKKGEDIFQVPEKLFKKADELGVKVPYSTAEIIAFLVEHAPIDDRLAKRDFTLFLDREDRLRVSECILEDFDEIGKHEGGKDTI
What is the function of this protein?
Putative transcriptional regulator.
What are the official names of this protein?
Putative transcriptional regulatory protein TK2151.
What is the protein family that this protein belongs to?
Belongs to the Tfx family.
Protein: HP3_ELSFA
Sequence: MSDSASPIFVEYRNTDLLLSPSSAHVYYLPVSSDKHIMLTASTTMGAVPLTTSTTPLVSSTVHQTVFRLRFDSAVTRLTPVTTTTSVTTGTLPWYIYQTPLVEIINTTRVTIGAPYDCDGFFWGRELRPNPDISGVGVVFAFMLSAWLVWLITVYAFARGQIDASQVTSADTRFFRVQVKSSGWRWSSVFLRAILVFSDQQLVTGIAIMIATFASCQDISVWHYAFAVSLAWVSHQHYCSLKTQHCVLD
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of elsinochromes, pigments consisting of at least four interconvertible tautomers (A, B, C and D) that have a core phenolic quinone to which various side chains are attached and which play an important role in fungal pathogenesis (PubMed:18957608).  The non-reducing polyketide synthase PKS1 was proposed to iteratively catalyze decarboxylation between acetyl-CoA and malonyl-CoA subunits for polyketide chain elongation.  The released polyketide undergoes cyclization to form an aromatic ring, and proceeds via serial modification steps to produce the heptaketide back- bone of elsinochrome.  As elsinochrome has a symmetrical structure, two identical heptaketides are fused to form a core 1,2-dihydrobenzo-perylene ring structure, which can then be successively modified to produce the various derivatives of elsinochrome.  Some of these reactions may be cooperatively carried out, at least in part, by the products of RDT1, OXR1 and PKS1.  PRF1, embedded within the elsinochrome cluster possibly functions to stabilize some of the biosynthetic enzymes required for elsinochrome production.  As prefoldin is a hexamer containing 2 a and 4 b subunits, additional prefoldin subunits, whose coding genes may not immediately link to the elsinochrome biosynthetic gene cluster, are required to fulfill the chaperone function.  In addition, no methyltransferase-coding gene exists within the biosynthetic gene cluster, even though elsinochrome has four methyl groups at positions C3, C7, C8 and C12.  Apparently, the identified gene cluster does not contain the entire entourage of genes responsible for elsinochrome biosynthesis.  Once elsinochrome is synthesized, it must be exported outside the fungal cells, which is probably accomplished by the ECT1 transporter, to avoid toxicity (PubMed:21199563).
What are the official names of this protein?
Elsinochromes biosynthesis cluster protein HP3.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YGGU_ECO27
Sequence: MSAVTINDDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANSHLVKFLGKQFRVAKSQVVIEKGELGRHKQIKIINPQQIPPEIAALLN
What are the official names of this protein?
UPF0235 protein YggU.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: RS21_SHEB5
Sequence: MPIIKVRENEPFDVALRRFKRSCEKAGILADVRAREFYEKPTTARKRAKAAAVKRLAKKLSRENARRVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CRCB_SULSY
Sequence: MEKYLVIAVGGSIGAILRYLTGVYSAKFFGTWLPYGTLIVNVVGSFILSFFMILFLEKLSLDPLWRLFVAVGFCGSYTTLSSITYETLSIVMDGDYVRALLNIALNFGLSFLSAFAGIVLARML
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MAP21_AJECG
Sequence: MAAQVIPELQSLNLKTEGGALPQELAPSGAPENEDGDSEDDNGDDQGADESRTIEVLAAKKKKKKKPKKKKKDTQKAQTEPPRVILSALFPNNEYPVGELVEYKDENAYRTTNEEKRYLDRMNNDFLSEYRYAAEVHKQVRQYAQKTIKPGQTLTEIAEGIEDSVRALTGHDGLTEGDNLLGGIAFPTGVNLNNCAAHYSPNAGNKMVLQYEDVMKVDFGVHMNGRIVDSAFTIAFDPVYDNLLAAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVEIKGTTYPVKAIRNLNGHTIGQFEIHGGKNGKSVPIVKGGDQSKMEEGEVYAIETFGSTGRGYVRDDMETSHYAKVPDAPNVPLRLSSAKNLLNVITKNFGTLPFCRRYLDRLRQDKYLLGLNNLVANGLVDAYPPLCDIKGSYTAQFEHTILLRPNIKEVISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_MANSM
Sequence: MSREFKRSDRVAQELQKEIAVILQREVKDPRIGMVTVSDVEVSRDLAYAKIFVTFLFNNDDEAIKQGMKALEKAAPYIRSLVGKAMRLRIVPELRFEYDRSLVEGMRMSNLVTNVVRSDKERHIDEENGED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_HAEI8
Sequence: MQLNSTEISELIKKRIAQFDVVSEARNTGTIVSVSDGIIRIHGLSDVMQGEMIALPGNRYAMALNLERDSVGAVVMGPYADLAEGMEVQCTGRILEVPVGSGLLGRVVNTLGQPIDGKGEIENDDFSPVEVIAPGVIDRRSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAIDAIINQRNSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVAASASESAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEDYVEKFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGGSAQTKVIKKLAGGIRTALAQYRELAAFAQFASDLDDATRKQLSHGEKVTELLKQKQFAPLSVAEQAVILFAVEFGYLDDVELSKIASFETALLDYSNRNHAEFMQELNKTGNYNDEIKDTLKSILDGFKANSAW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RODZ_SALDC
Sequence: MNTEATHDQNEAQTTGVRLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPSDLASTFLRGYIRSYARLVHVPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMSFTWLVLFVVVGLTGAWWWQNHKAQQEEITTMADQSTAELNADKDSGQSVPLDTGAVTSQDTTPAQTAPAPATPVDSTAATQTPAPTAAATQNTVVAPSQANVDTAATSAAPAATETPSALPTSQAGVAAPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEPTPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.