PharMolix/UniProtQA huggingface dataset:
Protein: T1353_SHIFL
Sequence: MYSYEDRLRAVRLYLKLGRRMSATLRQLGYPTKNSLKAWLAEFERNQDLRRGYQRIKRQYTDEQKQRAVDHYIEQGYCLSHTIRSLGYPSREALRAWIRDLRPEFARTVVGSSAPTVARSRLEKQQAVIALNLRVGSAKDVADTVGVSRPTLYNWQHRLLGKVPLKPMTKKKGDTSLEQRHEALLRELAELESQNQRLRMENAILEKASELIKKDMGINPLELTSREKTKVVDALRVTFPLANLLCGLKLARSTYFYQRLRQTRPDKYTQVREVIRTIFEDNYRCYGYRRIDSALRLGGMRVSEKVVRRLMAQERLVVRTPRRRRFSAYAGDPTPAVPNLLNRDFHASAPNTKWLTDLTEIHIPAGKVYVSPIVDCFDGLVVAWNIGTSPDANLVNTMLDHAVRTLRPGEHPVIHSDRGSHYRWPAWIRRTENAQLTRSMSKKGCSPDNAACEGFFGRLKTELIYPRNWQHVTLKDLMTRIDAYIHWYNERRIKVSLGGRSPIEYRHAVGLMSV
What is the function of this protein?
Probably involved in the transposition of insertion sequence IS1353.
What are the official names of this protein?
Probable transposase for insertion sequence element IS1353.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: GLUQ_PSEU2
Sequence: MKKPACIGRFAPTPSGYLHFGSLVAALASYLDARAADGQWLLRMEDLDPPREVAGAQAGILETLERYGFEWDGQMVRQSERHDAYAEILQRWFNHGLAYACTCSRKQLEGFQGIYPGFCRNAGHSPDNAAIRIRVPELEYRFDDRVQGTFKMHLGRESGDFVIRRRDGLYAYQLAVVIDDAWQGVTDIVRGADLLDSTPRQLYLQELLGLPQPRYLHVPLITQPDGHKLGKSYRSPPLPADQATPLLLRALRALGQPLDTHMADGTAQEVLAWGIRHWNADLIPRLRNIEEARID
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: RPOB_XANOR
Sequence: MTSYSFTEKKRIRKDFGKQRSILEVPFLLAIQVDSYREFLQEDVESTKRKDLGLHAALKSVFPISSYSGNAALEYVGYKLGQPVFDERECRQRGMSYGAPLRVTVRLVIYDRESSTKAIKYVKEQEVYLGEIPLMTGNGTFIVNGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDALFTRIDRRRKLPVSILLRALGYNNEEMLAEFFEINTFHINPDEGVQLELVPERLRGETLNFDLADGDKVIVEAGKRITARHVKQLEAAGVAALAVPDDYLVGRILSHDVVDGSTGELLANANDEISEDQLTAFRKAGVDAVGTLWVNDLDRGPYLSNTLRIDPTKTQLEALVEIYRMMRPGEPPTKEAAQNLFHNLFFTFERYDLSTVGRMKFNRRVGRKDVLGESVLYDKKYFAERNDEESKRLVAEHTDTSDILEVIKVLTEIRNGRGVVDDIDHLGNRRVRSVGEMAENVFRVGLVRVERAVKERLSMAESEGLTPQELINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEVTHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCTIETPEGPNIGLINSLAVFARTNQYGFLETPYRKVLDGKVSDDVEYLSAIEENEYVIAQANALTDAKNMLTEQFVPCRFQGESLLKPPSEVHFMDVSPMQTVSVAAALVPFLEHDDANRALMGANMQRQAVPTLRSQKPLVGTGIERAVARDSGVTVNALRGGVIEQIDAARIVVKVNEAEIGGGTDAGVDIYNLIKYTRSNQNTCINQRPLVNVGDVIARGDVLADGPSTDIGELALGQNMLIAFMPWNGYNFEDSILLSERVVEEDRYTTIHIEELTCVARDTKLGPEEISADIPNVSEQALNRLDESGVVYIGAEVRAGDIMVGKVTPKGESQLTPEEKLLRAIFGEKASDVKDSSLRVPPGMDGTVIDVQVFTRDGIEKDKRARQIEENEIKRVKKDFDDQFRILEAAIYARLRSQIVGKVANGGANLKKGDSVTDAYLDGLKKSDWFQLRMKDEDAADAIERAQKQIQAHEKEFEARFADKRGKITQGDDLAPGVLKMVKVFLAVKRRIQPGDKMAGRHGNKGVVSNVVPVEDMPYMATGESVDIVLNPLGVPSRMNIGQILEVHLGWAAKGLGRKIQRMLEAQAAVSELRKFLDDIYNHDNAINAQRVDLSQFSDEELLNLGKNLIDGVPMATPVFDGASEAEIKRMLELADLPQSGQTQLYDGRTGEAFDRKTTVGYMHYLKLNHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVQGRNQMYKNIVDGEHEMVAGMPESFNVLVKEIRSLAIHMELEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PHR2_ARATH
Sequence: MDSSNVEENLNPETKSAEEQNPLAIFHSSLPIASLSLTLFPSSTQFLKLFAHHPNKVKIPTQASSLTHLSLSSVSPFPSSRISFKSTIAANPLQSPLSIVPRRPVDPSSAAALRRAAVVWFRNDLRVHDNECLNSANDECVSVLPVYCFDPRDYGKSSSGFDKTGPFRAQFLIESVSELRKNLQARGSNLVVRVGKPEAVLVELAKEIGADAVYAHREVSHDEVKAEGKIETAMKEEGVEVKYFWGSTLYHLDDLPFKIEDLPSNYGAFKDKVQKLEIRKTIAALDQLKSLPSRGDVELGDIPSLLDLGISPTPRTSQEGKPTMVGGETEALTRLKSFAADCQARLSKGNQKGGNNSVFGANFSCKISPWLAMGSISPRSMFDELKKTISASTTSTTPRNGPGDTGLNWLMYELLWRDFFRFITKKYSSAKTQVEAGPATACTGAFA
What are the official names of this protein?
Blue-light photoreceptor PHR2.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-1 family.
Protein: NEP_I73A4
Sequence: NTVSSFQDILMRMSKMQLGSSSEDLNGMITQLESLKLYRDSLGEAVMRMGDLHSLQSRNEKWREQLSQKFEEIRWLIEEVRHRLKNTENSFEQITFMQALQLLLEVEQEIRT
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs to which the M1 protein is bound.  Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced (By similarity).
What are the official names of this protein?
Nuclear export protein, NEP, Non structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: DMON1_CAEEL
Sequence: MFRSIAVLSALLFAFASAKTCKYDSSDFEVYWRFANNSINMQFMNTDIKNNEWTGVGFGDDKNNFVGVFFMVSNNQVTVRTGSTTQHGPPTFTQSGTNTASVSTQALNYFPEDKTMSAVVQIPIQFNGRSLQSCQKWRFVKSGKIENGQLTRNDKSPKEKKVCPMECN
What are the official names of this protein?
DOMON domain-containing protein Y73F4A.2.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM1_THIDA
Sequence: MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTVSPDALSQWFADFHHLDVRELAPYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQAVAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVSMAAAAVRLAERIFPSVKEQACLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYDIIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLGQVVREGMDNRVAQVAQAEAIIETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAHKALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEERAELVRLISQLYGLHPE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PSAK2_NOSS1
Sequence: MLSSILLAAQATVPNTGTTWNWNGTPIIIASCLLVLLIAGRSIRYPHVGTKMPLPFPSIFNNPSVATFLAAMSFGHIIGVAAVLGLTNLGVI
What are the official names of this protein?
Photosystem I reaction center subunit PsaK 2, Photosystem I subunit X 2.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: MPH1_COCIM
Sequence: MADDGCSGLSDFITDDELFNEVTLNEVSDSQTGRPTKRRRLNSHEINTDSTGRREIEEAGTDSDTFDPSLPPNSKTTGRGRKSNDDNPAARKPKTYTPKYHVDQKPLFVTQTQPSSSPSRIRGPRWKAPERNKPSTVSKAKQKSPLPAIWGRKPSTIGSHGTNGKDIDAAIAASLRSFEEEQSARGDAEMLDDSIEEPGDTQVHATPGPVTNAEKETIFDFEDIPDDAFDFEPEFTETADKEPILISSQPRPSQNTTRRPTASQSTSFRQTTLLGGFASSSSKRSSQPATQTWPSSSRNEPPTHHELNKDALRTWIFPKNLGSRREYQFNIAHRALFHNLLVALPTGLGKTFIAATVMLNWFHWTKDAQIVFVAPTKPLVSQQVDACFHIAGIPRSQTTLLTGNTPPGVRAEEWRSKRVFFMTPQTIMNDLKTGIADPKRIVLLVVDEAHRATGAYAYVEIVKFLQRFNNSFRVLALTATPGATVEAVQEVIDGLSISRIEIRTEKSLDIRGFVHQRNVETITFENSRDMITSMELFAKALQPVVDRLRNQNAYWGRDPMALTPFGLTKARQEWNSSPAGRAASWPVKGTINSMFTVLASLAHAIDLLKYHGIGPFYRNLVSFEDSVLKEKKGGKCASQIVADGNFKVLMSKLRSWTNTEEFIGHPKLEYLRRAILNHFLDAGGKNGGDSEGSDSNTRVMIFSHFRDSAEEIVRVLRKHQPFVRPHVFVGQANAKGSEGMDQKTQLEVVGKFKTGTYNTIVATSIGEEGLDIGEVDLIICYDGHSSPIRMLQRMGRTGRKRAGNIILLLSKGKEEESYSKAKDSYEKMQQLIASGSRFTFHTDKSSRIVPQDIQPEAEEKMIEIPIENSQLGLPEPAKRSRAPKRPPKKFHMPDGVEKGFTKASRLGRTNTDSNGRSKRKRVVRTPSPELEEFPDLGDLCANQSQELADDPDFQEIAGKQIPRLRMDVYPEHQRSLRPTGFIEHGKYTRRVVKTFRKISKLGFDCEAQYRAIVGDPDDDGEGLEGLSTDREDDPQSVTAHQSREQPPRVEKRCGTEELSSLDIEAFFPNLAWPARPEAPRPESDGTDNRDQKPSQRKKRYMISDDSDVFE
What is the function of this protein?
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance.  Capable of unwinding D-loops.  Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair.  Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
What are the official names of this protein?
ATP-dependent DNA helicase MPH1, FANCM-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HFA7A_ARATH
Sequence: MMNPFLPEGCDPPPPPQPMEGLHENAPPPFLTKTFEMVDDPNTDHIVSWNRGGTSFVVWDLHSFSTILLPRHFKHSNFSSFIRQLNTYGFRKIEAERWEFANEEFLLGQRQLLKNIKRRNPFTPSSSPSHDACNELRREKQVLMMEIVSLRQQQQTTKSYIKAMEQRIEGTERKQRQMMSFLARAMQSPSFLHQLLKQRDKKIKELEDNESAKRKRGSSSMSELEVLALEMQGHGKQRNMLEEEDHQLVVERELDDGFWEELLSDESLASTS
What is the function of this protein?
Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
What are the official names of this protein?
Heat stress transcription factor A-7a, AtHsfA7a, AtHsf-09.
What is the protein family that this protein belongs to?
Belongs to the HSF family. Class A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_BRASO
Sequence: MALPEFTMRQLLEAGVHFGHQSHRWNPKMADYIFGARNNIHIIDLAQTVPLLHTALQAVSDTVAKGGRILFVGTKRQAQDNVADAAKRCAQYFVNSRWLGGTLTNWKTISASIKRLRHLDEVLSSGEANSYTKKERLTLQRERDKLDRSLGGIKDMGGLPDMIFVIDTNKEDIAIQEAQRLNIPVAAIVDTNCDPKGITYVVPGNDDAGRAISLYCDLIARAAIDGISRAQGELGIDVGASAAPLEEDLPAASASTFQGLPGPRGTADDLKKLTGVSGAIEKKLNDLGIFHFWQLAELNHDTAHQIGEEVGLPSRADAWVAQAKSLADA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: DIE_DROME
Sequence: MASPVVSLLLVGICALAFVHVARSECCTSRELVEFKMDRGDCEAVRAIENYPNGCEVTICADGVAQLGAYCGQGSCNIFGCNCDGGCLSGDWSQEFVRRNQQYGIQIIKVTRLPF
What is the function of this protein?
Cytokine which promotes survival following infection by Sindbis virus by suppressing the immune deficiency pathway (PubMed:26739560).  Following infection by the enteropathogenic bacteria E. carotovora limits intestinal stem cells proliferation (PubMed:30036358).  When secreted from muscle or adipose tissue, can attenuate age-related intestinal tissue degeneration by inhibiting apoptosis (PubMed:30036358).
What are the official names of this protein?
Protein Diedel.
What is the protein family that this protein belongs to?
Belongs to the Diedel family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the hemolymph.
Protein: CDR_STAAB
Sequence: MPKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYALAYTPEKFYDRKQITVKTYHEVIAINDERQTVSVLNRKTNEQFEESYDKLILSPGASANSLGFESDITFTLRNLEDTDAIEQFIKANQVDKVLVVGAGYVSLEVLENLYKRGLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRLNEEIVAINGNEITFKSGRVEHYDMIIEGVGTHPNSKFIESSNIKLDRKGFIPVNDKLETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAASIVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHANYYPGNSPLHLRVYYDTSNRQILRAAAVGKEGVDKRIDVLSMAMMNQLTVDELTEFEVAYAPPYSHPKDLINMIGYKAK
What is the function of this protein?
Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide.
What are the official names of this protein?
Coenzyme A disulfide reductase, CoA-disulfide reductase, CoADR.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
Protein: VP52_BPAPS
Sequence: MRFGASLNCGASGWVKSTKSPLTSLWTNCAWAKHNPPFALQNRHCLTPGEKALSGRASRPLRSARVAIFMAFCAPDLACSPKSFKSSTDTAHSDRWLSLG
What are the official names of this protein?
Putative protein p52.
Protein: TRUD_THET8
Sequence: MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTREVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLVEDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: LYS_CRAGI
Sequence: MQRLLGSIVILATVFTFCEATISSACLRCICNVESGCRPIGCHYDVYSYSCGYFQIKENYWEDCGKPGTSFKACANDYTCASNCVRAYMKRYIGSSGCPANCESYARIHNGGPRGCRHPSTLRYWEKVHQQGCNVNS
What is the function of this protein?
Has bacteriolytic activity (By similarity).  May play a role in digestion and in the host defense mechanisms against invading microbes (PubMed:16996284).
What are the official names of this protein?
Lysozyme, 1,4-beta-N-acetylmuramidase, Invertebrate-type lysozyme.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL37A_CAEEL
Sequence: MAKRTKKVGIVGKYGTRYGASLRKMAKKLEVAQHSRYTCSFCGKEAMKRKATGIWNCAKCHKVVAGGAYVYGTVTAATVRSTIRRLRDLKE
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: RNC_LEIXX
Sequence: MVGENTDRSALLEKLGVDIDPELLELALTHRSYAYENGGIPNNERLEFLGDSILGQAVTVKLFRENPGLDEGELAKRRASLVSSVALAEVARGIGLGEYLLLGRGENQSGGREKASILADTVEAVIGAVYLDAGGDEATALVLRLIGPLLADPDRFGAAMDPKTSLQEAAAHHGAGQPVYTVINTGPDHSKTFHATVDVGGLVTASGEGTSKKQAEMAAALSAWTALTNHRARTPRG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_ECO8A
Sequence: MTLWINGDWITGQGASRVKRNPVSGEVLWQGNDADAAQVGQACRAARAAFPRWARLSLAERQVVVERFAGLLERNKGELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRTLLAPRLLQSETSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDSFEEAILMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: GNAI3_CRIGR
Sequence: GSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
What is the function of this protein?
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins.  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels.  Stimulates the activity of receptor-regulated K(+) channels.  The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  May play a role in cell division.
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-3, G(i) alpha-3.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Protein: ISPD_CERSK
Sequence: MTTAAIIVAAGRGTRAGGDLPKQWQPLAGRPVLAHTLAAFRAAAGVSRTLLVIHPDDRARAEALPGVAEGKVELVEGGASRDASVRNALEALAGAGIERVLIHDGARPLVAPGLIARTLAALESAPGAAPAVPVSDALWRGEGGRVVGTQDRTGLFRAQTPQAFRYEAILAAHRAHPGGAADDVEVARAAGLEVAIVEGCEDNLKVTYPGDFARAERLLALAAGL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RNH2_SPHAL
Sequence: MRTDSGVWLTVVAHMIVGVDEAGRGPLAGPVVAAAVLLCEGGIAGLDDSKKLSARRRGALESAIRAQCRWGIGEASVEEIDRINILQATFLAMTRAVEALGFEPAEVLVDGNRLPRWRYQARAIVGGDALHPCISAASILAKQHRDRLMIAAAQDYPAFGWESNMGYGTAQHLAALRRHGPTPHHRTSFAPVAQLQLV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REV_HV19N
Sequence: MAGRSGDPDEELLRAVRIIKTLYQSNPYPSPAGTRQARKNRRRRWRARQRQIHSISERILSACLGRPAEPVPFQLPPLEGLSLDCSKDGGTSGTQQPQGTETGVGRPQVLVEPPVVLGSGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: GAL1_ESCF3
Sequence: MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRNVRVMAADYENQLDEFSLDAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKNHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_AERS4
Sequence: MTASLWQQCLNRLQDELPSAEFSMWIRPLQAELSDNTLTLYAPNRFVLDWVRDKYLIRVNGIINELCGVDGPTLRFDIGNRPHPVAIARAPARGAAPVNNLQKSWESKADAKPEPNHKSNTNVNYTFENFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNAIKERKKDAKVIYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKADENQIHLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAINIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKLADLLSKRRSRSVARPRQLAMALAKELTNHSLPEIGDAFGGREHTTVLHACRKIEQLKEESHDIKEDYSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFC_ACTSZ
Sequence: MTDVLTRYNSGKLWDFDGGIHPPEMKSQSNSTPISTALLAEDYYVPVKQHAGNAGNLLVKEGDYVLKGQPLTLGDGLRVLPVHAPTSGTVVAIEPHIAAHPSGLSELAVHIHADGKDQWRPQNPTEDYFTHTPERLIEKIYRAGVAGLGGAVFPTGAKVDAALGKVKLLIINGAECEPYITCDDRLMRDYAAEIIEGVRILRYILRPEKVVIAIEDNKPEAVNALRTSLQGANDMDIRVIPTKYPSGAAKQLIYVLTGMEVPHGQRSSSIGVLMQNVGTAFAVKRAVINDEPLIERVVTLTGDKIPHKGNQWVRLGTPIDFILKHVGYQPDNRFPVFVGGPMMGLIVPDLRAPITKTANCLLAPDHFEYDPQATEQACIRCSACSDACPVHLMPQQMYWYARAEDHEKSNQYQLMDCIECGLCAYVCPSHIPLIQYFRQEKAKIWDIEAKARKSEEAKIRFEARQARLEREEQARKARSQRAAAARREELAANKGEDPVQAALARLKAKKAGEAPETGGSAQGAPHIKTIRTEKGQSVPDNSEITALRRARRLARQQTNGNSPVSSASNSDSATISADNTHSTPKTAQNQTAPDPKKAAVAVAIARAKAKKAAQTTTGETVTENVTEKTAQNPTAPDPKKAAVAAAIARAKAKKAAQATTGETATEKTAQNPTAPDPKKAAVAAAIARAKAKKAAMLAESEKK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rnf electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.