PharMolix/UniProtQA huggingface dataset:
Protein: HEMA_I66A0
Sequence: MERIVIALAIISVVKGDQICIGYHANNSTKQVDTIMEKNVTVTYAQDILEKEHNGKLCSLKGVRPLILKDCSVAGWLLGNPMCDEFLNVPEWSYIVEKDNPTNGLCYPGDFNDYEELKHLMSSTNHIEKIRIIPRNSWSEHNASSGVSSSCPYNGRSSFYRNVVWLIKKNNSYPTIKRTYNNTNVEDLLILWGIHHPADAAEQTRLYKNSNTYVSVGTSTLNQRSIPEIATRPKVNGQNGRIEFFWTILRPNHAISFESNGNFIAPEYAYKIVKKGDSAIMRSELEYGNCDTKCQTPVGAINSSMPFHNVHPLTIGECPKYVKSNKLVLATGPRNVPQRRKKRGLFGAKAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTHKAIDGITNKVNSIIDKMNTQFEAVGKEFNNLERRIENLNKQMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEESRLNREEIDGVKLESMGTYQILSIYSTVASSLALAIMVAGLSFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: ACTB_SPECI
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells.  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction.  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: ARGC_TERTT
Sequence: MIKVGIVGGTGYTGVELLRLLAVHPKVEVTLITSRAEAGKCVTELFPTLRGHYDDLYFSEPESHALGACDLVFFATPHGVAQAMMKEVLAAGVRAIDLSADFRIRDIEVWEKWYGQQHGCPELVAQAVYGLPEIHREQIKDAQLVACPGCYPTSIQLGFYPLLANDLIDPRSLIASSASGVSGAGKQAKVDLLMAEMGESFKTYAAGGHRHLPEIEQGLRDMQTPDAAEPELTFVPHLLPMIRGIHSTLFARLIENVDLQALFEDFYANEPFVDVLPQGVLPETRSVKSSNICRLAVLEPQSRGTVVVASVIDNLTKGASGQGIQNMNIMFGFDETMGLAAPALLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A1D_RALPJ
Sequence: MNLQRFPRYPLTFGPTPIQPLKRLSAHLGGKVELFAKREDCNSGLAFGGNKTRKLEYLIPEALEGGYDTLVSIGGIQSNQTRQVAAVAAHLGLKCVLVQENWVNYSDAVYDRVGNIEMSRIMGADVRLDSAGFDIGIRPSWEQAMDDVRKRGGKPFPIPAGCSEHPLGGLGFVGFAEEVRQQEAELGFKFDYIVVCSVTGSTQAGMVVGFAADGRADKVIGIDASAKPEQTRAQILRIAQHTAELVDLGRNITERDVVLDTRYGGPEYGLPNEGTLEAIRLCARQEAMLTDPVYEGKSMHGMIDMVRNGEFPAGSRVLYAHLGGVPALNAYSFIFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: MNTP_SODGM
Sequence: MNLSATLILAFGMSMDAFAASVGKGATLHKPALREALRTGLIFGVIEAITPLIGWGLGLLSSQYIMRWDHWVAFTLLAFLGGRMVLAGWKQQPLETSLVGKHSLGVLIATAIATSLDALAIGVGLAMLQVNILHAALLIGLATLIMSTIGMLLGRFVGPCLGSKAEIIGGLILIGIGCNILYSHIGEAMLAHLPG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: A4_FELCA
Sequence: DAEFRHESGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
What is the function of this protein?
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.  Interaction between APP molecules on neighboring cells promotes synaptogenesis.  Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity).  Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity).  Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity).  Inhibits G(o)-alpha ATPase activity (By similarity).  Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity).  May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity).  In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity).  Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.  Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons.  Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
What are the official names of this protein?
Amyloid-beta precursor protein, ABPP, APP, Alzheimer disease amyloid A4 protein homolog, Amyloid precursor protein, Amyloid-beta (A4) precursor protein, Amyloid-beta A4 protein.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles. During maturation, the immature APP (N- glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface.
Protein: HLDE_VIBC1
Sequence: MKPILPDYNSAGVLIIGDVMLDRYWYGPTGRISPEAPVPVVKVENNEERPGGAANVAMNIASLGGHAHIVGLTGMDEPAKVLTETLNSLKVKCDFVALPEYPTITKLRVMSRGQQLIRLDFEDKFENTDAEPVLSRMETALPSVKAVIMSDYAKGSLEHVQAYIQKARAANIPVFIDPKGADFERYRGATLLTPNMKEFEDVVGKVKSDQELVEKALALVEEFEFEALLVTRSENGMTLIRRGQEPFHLPTQAKEVYDVTGAGDTVISVLAASVAAGKSFEEACALANAAAGVVVGKLGTSTLSEIELAEAIHGSQDTDYGVISEQALIEAVKKARAKGEKVVMTNGCFDILHAGHVSYLNHAAELGDRLIVAVNTDESVKRLKGPGRPVNPTDRRMAVLAGLGAVDWVVPFSEDTPQRLISEVLPSLLVKGGDYKPEEIAGGKEVIAAGGEVRVLNFEDGCSTSEIINAIKGGKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: MIAA_BORPD
Sequence: MSSAAPIVCLAGPTAAGKSAATLALAQRWPLEVVNVDSATIYRGMDIGTAKPSPAEQARVPQHLLDIRDPAQSYSAAEFRADALRLIDEIRARGRMPLLAGGTMLYYKALRDGLDDLPQADPALRAELEARAARLGWPALHAELARLDPATAARLAPNDSQRIQRALEICTLSGQPMSALLHGRQRAADATPHRYVTLSLEPSDRAALHARIAQRFDAMLAGGLLDEVRALRARGDLHPGLPSVRCVGYRQMWAHLDGAVDLETAREQAIAATRQLAKRQLTWLRAQPERLVVDCLAGNASGRVVDRVAEILAD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RS15_CAMLR
Sequence: MALDSAKKAEIVAKFARKEGDTGSPEVQIALLSARISDLTEHLKIYKKDFSSRLGLLKLVGQRKRLLSYLKRKDYQAYSKLISELNLRDK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SYT_MYCGE
Sequence: MLAGVLLLQIWLKCKYANVQFGEHGFNGDEFYLDFYINENFSTKQFAKIESDLNSLSSKLEGISQKFVSLDEALSFFENDQFTKNLLKKSNLNKFKITFFENKHFWIEDLTLTFIKKSFIKLLNVSVNYFLGDPSQLQLQRINGIFAQSKKELEQLIKENEERLKKDHRSLGKQLELFSFDPLIGAGLPIWLAKGTTLRNIIGNFVHHQQLLFGFNTVCSPVLANIELFKISGHYQHYKEDMFPAIKLDSQAMMLRPMTCPHHCLIFKQKRYSYKKMPQRFSEDSILHRFEASGGLIGLERVRCMTLLDNHIFCRADQIKSEIKNAFNLIQKVNKKFGFIFDRIDLSLHDPKNQSKFIDNPGLWRESESQMENVLKDLNIQYQKEIGAAAFYGPKIDFQFKTIFKKMITIATIQLDFLLPEKFDLTYIDKKNTLKKPVIIHVGIIGTYERFIAALLEKTSGNFPLWLAPVQAVIIPVNIQKHLKAAKKLYNKLLKENIRVNLDDNQDRLAKKVRQAIIEKIPLQLIVGDKEIENLEKLTCRGFKGEKITRISFNNFVKRVRRDG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_ACTSZ
Sequence: MESVITATIIGASILLAFAALGTAIGFAILGGKFLESSARQPELASSLQTKMFIVAGLLDAIAMIAVGISLLFIFANPFISLLQ
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRBB1_CHICK
Sequence: MSETTKTAAPGQAAEDKEKAAPAPAPSSDPTPVTNSKGEEPSTEAFRIVIFEQENFQGRQMEFTSECLNLADCGFDRVRSVIVSSGPWVAYEQANMRGEMFILEKGEYPRWDTWSSSYRSDCFMSMRPIRMEAEDHKISLYESADFKGNKMDIQEDDVPSLWAYGFCDRVGSVKVPSGTWVGYQYPGYRGYQYLFETGDFRHWNEWCAFQPQIQSIRRIRDMQWDQKGTFVTPEAPSN
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Beta-crystallin B1, Beta-35, Beta-B1 crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: MK67I_BOVIN
Sequence: MAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ
What are the official names of this protein?
MKI67 FHA domain-interacting nucleolar phosphoprotein, Nucleolar protein interacting with the FHA domain of pKI-67.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
Protein: DER_GEOUR
Sequence: MRPLIAIVGRPNVGKSTLFNRIVGRRKAMVDDMPGVTRDRNYANVDRFDVPFILIDTGGFEPETNDRLLQQMREQSQLAMAEADVILFVMDGRDGLTPADVEVVEMLRRVDKPIFYLINKIDGDKQETAIGDFYTLGVDTIFTVSAEHNRGVNDLMDEVIKALPKGSAADTDEEVTKIAVIGRPNVGKSTLVNRLLGIERVVANPTPGTTRDSIDTYFTCNRKRYLLIDTAGIRRKGKTTEKIEKYSVVDSLRSIERADVVLIVIDAEEGVTEQDTKIAGYAYEAGRGCIFVVNKWDTLTKDNASMGKFIEKIRMEFKYLPFAPIVFVSAKTGQRLGKIMTEVDAVMEQFARRITTSDLNRVFSTATEEHHAPLYQGRRVKFYFATQVGTKPPSIVIFTNRPDGVHFSYERYIVNRFREAFGFTGTPMRLLFKGRESRKRA
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RL34_SHEB2
Sequence: MSKRTFQPSNLKRKRSHGFRARMATVGGRKVLARRRAKGRARLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: FLHD_ERWT9
Sequence: MEKMGTSELLKHIYDINLSYLLLAQRIINQEKVSAMFRLGIDEAMADALASLTLPEMVKLAETNQLVCQFRFNDHQSITRLTQESRVEDLQQIHTGILLSSRLLRDVSQENKTPKKRAVS
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_COLP3
Sequence: MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMTKRNNFTSGRIYQDVLARERKGEFLGATIQVIPHITNDIKRRVIEGAEGYDIAMVEIGGTVGDMESQPFLEAIRQLALEVGRDRAMFMHLTLVPYLAAAGEIKTKPTQHSVKDLRSIGIFPDILVCRSDRAIPNAERAKISLFTNVEEKAVVSMRDVDSIYKIPALLKAQGTDEIVVKRFGLDVPEADLTEWEEVLYHEANPIGEVTIGMVGKYTELPDAYKSVNEALKHAGLKNQVTVNIKYIDSQDVEVKGVEILANLDAILVPGGFGERGVEGKILTAQYARENKVPYLGICLGMQVALIEFARNVAGLTDAHSTEFNSETPHPVVGLISEWLDEEGQVEYRNEQSDLGGTMRLGSQLCHLVKGTKACDVYGSETINERHRHRFEVNNNYREQLSKAGLIFSGLSSDKSLVEVIEIADHPWFIAGQFHPEFNSTPRDGHPLFESFVAASFKLQKS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ARCA_MYCCT
Sequence: MEKKINVFSEIGTLKTVLVHRPGDEIENLTPELLERLLFDDVPFKDVAVKEHDAFTKIMRDNGVEVLYIEKLAAETLDQHPDLREKFIDQFISEANIEDKYKEKYRDFISSLDNYRMIKKMIAGTKKLELGIDEGYKAYPFIADPLPNVLFQRDPFSSVGFGITMNRMWSVTRNRETIFPDLVFKHHNRFANQVPYYYERDWKEETIEGGDILVLNKETLIIGVTQRTTLKAIEKFSERLFNDPESSYSKVIALDLPKSRAFMHLDTVFTNIDYDKFIAHPLIFDCIDEFKIYEVSKQGTKEVKKTLIELLSDAAGREVQIIRCGGNDVVGASREQWNDGTNVVALRPGKVIAYERNWITIDLLRKAGVEVLTIASSELSRGRGGPRCMTMPLWREDLQEIKR
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_APILI
Sequence: MMKWFMSTNHKNIGILYIILALWSGMLGSSMSLIIRMELSSPGSWISNDQIYNTIVTSHAFLMIFFMVMPFLIGGFGNWLIPLMLGSPDMAFPRMNNISFWLLPPSLFMLLLSNLFYPSPGTGWTVYPPLSAYLYHSSPSVDFAIFSLHMSGISSIMGSLNLMVTIMMMKNFSMNYDQISLFPWSVFITAILLIMSLPVLAGAITMLLFDRNFNTSFFDPMGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIVMNESGKKEIFGNLSMIYAMLGIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAVPTGIKVFSWLATYHGSKLKLNISILWSLGFIMLFTIGGLTGIMLSNSSIDIILHDTYYVVGHFHYVLSMGAVFAIISSFIHWYPLITGLLLNIKWLKIQFIMMFIGVNLTFFPQHFLGLMSMPRRYSDYPDSYYCWNSISSMGSMISLNSMIFLIFIILESLISKRMLLFKFNQSSLEWLNFLPPLDHSHLEIPLLIKNLNLKSILIKF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YAFY_ECOLI
Sequence: MKRKTLPLLALVATTLFLIACDDRSDDLKAISKFKDLTPPRFSDVVSHQDDVSEEWSQVDYLSGPTLQVLRTRQSPDGCEDGSYYYLVDMQEKTVQPLMNALCIADNIKLEYQEVTDPYTKEKYFEYAHDGKLMGQLLIPSNPDNQE
What is the function of this protein?
When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR (PubMed:15252048).
What are the official names of this protein?
Lipoprotein YafY.
What is the protein family that this protein belongs to?
To E.coli YfjS.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor.
Protein: DHPS1_MYCBO
Sequence: MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRADVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVISALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: ARNF_ECO5E
Sequence: MGLIWGLFSVIIASVAQLSLGFAASHLPPMTHLWDFIAALLAFGLDARILLLGLLGYLLSVFCWYKTLHKLALSKAYALLSMSYVLVWIASMVLPGWEGTFSLKALLGVACIMSGLMLIFLPTTKQRY
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPAB2_YEAST
Sequence: MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
What is the function of this protein?
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  RNA polymerases are composed of mobile elements that move relative to each other.  In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC2, RNA polymerases I, II, and III subunit ABC2, ABC23, DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TYSY_ENT38
Sequence: MKQYLELMKKVLDEGTPKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNVAYLRENNVSIWDEWADENGNLGPVYGHQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTHLQLTREPRALPKLVIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.