PharMolix/UniProtQA huggingface dataset:
Protein: NUON_ANAD2
Sequence: MSGFPTQDFVALVPVAILTMGALVLLMTEVFLTSGRRAYQAYLTMVFAAAAAGYAAWMPVPGNVFGRQAVVDSFSAFVTVVLCAGLALSALVGQSWLNARNSERGEFYALALFGTAGMVLLGMATDLLIAFIAVEVMSLSTYCLAAFLRRGKKPAEAAFKYVVLGSISSALLLYGSALLYGASGSTLFSVLPRGQGSALYLAGIALVAGGVAFKIAAVPFHAWTPDVYEGAPTPVTAFMAAGVKTAAFAVLVRLFLATESGSAAMSTSLGTVLSALAVLTMIFGNLLALPQRSVKRMLAYSSIGHAGYLLVGVVSAVVAGARDKALAGLLFYLAAYTATVIGAFAVVGALERRTRGDFEPADAWDLDRFAGLARRRPALAFAMAVFLFSLAGVPPTAGFIGKFYIFKAAMGAGLYGLAVLGVLTSVLGAYYYLRVVLYMYFLPSKDEAGEVVLSAPSLTIALAAAVAVVVLLGVVADPMVRLAQAASAIIL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL20_AGARV
Sequence: MARVKGGLGAKKRHNRTLKLAKGYRGARSKQYRVAKQSVMRALTSSYAGRKERKRQFRQLWIARINAAARLNGLSYSQFMHGLKLANVDLNRKVLADMAVTDAAGFAKLVEVAKSKLA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RNPA_SALNS
Sequence: MVKLAFPRELRLLTPAHFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: CSK_PHATC
Sequence: MSSIYLHGLSRRRRIGSVIVAIYMLDSCGAFLSASGSGRYPGFSYRGLSVVTENIRSIHSSRRLKLTVNATNKEMYERQDSIHTLPLSPIPVMPSQLFQELALSQLELLANSIPCADRPGVSKIKTMALYLPQENVNTGQLEFLPAIHYPHPSRERVFIANEAASGVAPALPRTLTTLPGFAHATSLLPGYPMVSGGSEASVGVVEEVICDLTSGAAALSVPLFSGSRTVGVLLVSPSISKRRKGSAWTKEDREQVGRAGKSLSLALSMDTERAALQMQNDRAARALSDSLHQIKNPLQAMRTYGKLLQRRIADLGLLSNEGMTPQLLEMAEHLLVQSDRLADRLKPVDTIVDSLSERTPFVLNPAAPTKTQDSLVSLATPLVPWESETLEFARESKTSGELVIFMPTKKVAASGSNGPSNSTTSFSGNGSDVSTYTEDDGAGEMPSSLFSEMDLEMSFLSDVLDPVLAAFRAIAEDRGIMFSHDDTEDLPGVTICPQALQEALINVIDNAFTYVFLPKPGSRFGPNPSAEVRIRLVQNSKGSDAGVTILVEDNGPGIPAETRDQIFDRGKDQALDWTLRKHW
What is the function of this protein?
Sensor kinase that senses the plastoquinone (PQ) redox state involved in stoichiometry adjustment of both photosystems (e. g.  long-term adaptation via transcriptional regulation of reaction center genes of photosystems I and II) and state transitions (e. g.  short-term adaptation involving reversible post-translational phosphorylation of light-harvesting complex II, LHC II), thus linking photosynthesis with gene expression in chloroplasts (By similarity).  Reduced PQ suppresses its autophosphorylation activity (Probable).
What are the official names of this protein?
Chloroplast sensor kinase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the chloroplast sensor kinase protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Note=In this organism the plastid is the result of a secondary endosymbiosis event, and is found within the endomembrane system, necessitating a complex targeting process.
Protein: SEC14_YEAST
Sequence: MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGGLYLSDIGPWRDPKYIGPEGEAPEAFSMK
What is the function of this protein?
Required for transport of secretory proteins from the Golgi complex.  Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes in vitro.  Essential for viability and secretion (PubMed:2466847, PubMed:2215682).  Exchanges its bound phospholipid with phospholipid monomers that reside in membrane bilayers (PubMed:16997918).  Regulates specific trans-Golgi export pathways, like transport from endosomes to the trans-Golgi or transport from the plasma membrane to the vacuole at the level of the endosome (PubMed:19129178).  Increased membrane curvature and lipid unsaturation levels at the trans-Golgi membrane promotes membrane binding and phospholipid transfer of SEC14.  Thus, SEC14 may act at the trans-Golgi membrane to exchange lipids and promote vesicle formation (PubMed:32828847).  The phosphatidylcholine-bound form of SEC14 represses the CDP-choline pathway activity by inhibiting CCTase, the rate-determining enzyme of the CDP-choline pathway (PubMed:7816798).  PI binding/transfer is dispensable for function in vivo (PubMed:10488334).  Required for trafficking and localization of lipid raft proteins to the plasma membrane (PubMed:23383173).
What are the official names of this protein?
SEC14 cytosolic factor, Phosphatidylinositol/phosphatidylcholine transfer protein, PI/PC TP.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm.
Protein: SL9A1_RABIT
Sequence: MLLWSAVRGLSPPRIVPSLLVVVALAGLLPGLRSHGLQLSPTDSTTPDSQPSRERSIGDVTTAPPEVTPESRPVNRSVTEHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGEKPPFLQSEVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYDHVGIVDIVLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTAHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKALPAERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLSREPRVAEEAAEEDEDGGIVMRPKEPSSPGTDDVFSPAPSDSPSSQRMQRCLSDPGPHPEPGEGEPFIPKGQ
What is the function of this protein?
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions.  Major proton extruding system driven by the inward sodium ion chemical gradient.  Plays an important role in signal transduction.
What are the official names of this protein?
Sodium/hydrogen exchanger 1, Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 and CHP2 at the reticulum endoplasmic and plasma membrane.
Protein: RPOB_PARUW
Sequence: MLQRPPHRESFNDKEEIIDLPNLIEIQIKSYNQFLQADKFPDERENIGLQEVFTEIFPIKSYDEKTILEFLSYNLGVPKYNPEECIRRGITYNVTLKVKFRLTDETGIKEEEVYMGTIPVMTDKGTFIVNGAERVVVSQLHRSPGICFEQERHSRGNVIYSFRIIPYRGSWLEGAFDTNDLIHIYIDRKKRRRKILATTFIRALGYSSNSDIIEEFFTTRKYKIKNEKEFAKLVGKILAQDVVDEESGLVFGKASEKLTTAMLKRIVDAGIDVIRIAEDADETSPVIKMLAKDPTDSYESALKDFYRKIRPGEPATLSNARSAIMRLFFDPKRYNLGRVGRYKLNSKLGCEINDEKLQTVTLDKEDVIGALKYLIMLKSGSEEASIDDIDHLGNRRVRSVGELIQNQCRIGLARMEKIIRERMNLFDFSSDTLTPGKIVSAKGLSGVLKDFFGRSQLSQFMDQTNPIAELTHKRRLSSLGPGGLNRDRAGFEVRDVHTSHYGRICPIETPEGPNIGLISSLSSFAKINEFGFIETPYRIVREGVVTDEIEYMTADQEEQCVIAQASAPLDEYHMFAEPICWARYKGEQFETDTKNVTHMDVSPKQLVSIVTGLIPFLEHDDANRALMGSNMQRQGVPLLKPTAPIVGTGLEARAARDSGAVLIAHEDGVVDYVDGLKIVISPDDNRLEKRTYLLKKFIRSNAGTCINQRPLCHVGDKIKAGDVIADGPATDKGEVALGRNVLVAFMPWFGYNYEDAIIISEKLLREDYYTSLYIEEFELTARDTKLGKEEITRDIPNVSEETLRNLNDDGIIRIGAEVKPGDTLVGKITPKSETELAPEERLLRAIFGDKASDVKDASLIAPPGTEGVVMDVKVFSRRDRLSKTDDELVEEASKLKDIQREYKSNQAQLRTEKHERVGALLLNETAPGNIVHRRTAEIIVDEGDLITQDLIEALEKESVEDLLMPENDIYTTLRQILHDYEIALQTVETQYKTQLEFMRKGDTDLDPGVIRQVKVYVASKRKLQVGDKMAGRHGNKGVVSKIVPEADMPFLSTGQTIEIILNPLGVPSRMNMGQLFETHLGIAAKHTGITVKSPVFEGFPEEKIWEMMKKAGLPEDGKFFLYDGCSGERFDNSVVVGYIYMLKLSHLVADKIHARAVGPYSLVTQQPLGGKAQMGGQRFGEMEVWAAEAYGAAHLLQEMLTVKSDDVAGRTRIYESIVKGENLLKSGTPESFNVLIKEMQGLGLNVYTEAVDDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GCSH_NATPD
Sequence: MSFDVPADRRYLESHEWAQPDDDVVRVGITDFAQDELGDIVFVELPSVGDRIEHEAEFGVIESIKAVSDLYAPVSGEVVAVNDDLEDAPELVNDDPFGDGWLLEVEADGDDYESLLTADEYEAQIA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Probable glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: ARLY_ARCFU
Sequence: MLRESRMKKGMDPKALKLSSSIEHDKNIFLYDILVDVAHVLTLKKGGYLSEEEAKEIILALKKVKDSGFREDWPYEDVHEAIEAEVTKITPHGAKMHTGRSRNDEVATCLRMFARDHLLNLAEAILNALDVLIKKAEKSHFLMPGFTHLQYAQPTRLSHHLLAYHDMLSRDFERAIEAFRRVNKSPLGSAAFASTGYSLDRVYAARLLGFDGVVEHSEDAVASRDFVIESIFVAAEAMLSISRIAEEIVLFSSEFGFITLPDEFSSTSSIMPQKKNPDIAELLRANAGKIAGNLTSAMMIYKATPFSYNRDFQEMNPLLYESLKRTHLAVEVFASMMGKIKFNPEITERKASKGFATATELADMLVMKYGVPFRMAHRIVGRLAAKELERPTASDVNSAAKELGVEINVRDEDVLEALDVEKVVENRGNLGGTSKAEVERMIKARKSDLKDRKTLLRKLRGEVKMGLKMLYDEAKKLGVDINV
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP1_NOTPA
Sequence: MARYRHSRSRSRSRYRRRRRRRSRYRSRRRRYRGRRRXRSRRGRRRGYSRRRYSRRRRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DNLJ_THET8
Sequence: MTLEEARKRVNELRDLIRYHNYRYYVLADPEISDAEYDRLLRELKELEERFPELKSPDSPTLQVGARPLEATFRPVRHPTRMYSLDNAFNLDELKAFEERIERALGRKGPFAYTVEHKVDGLSVNLYYEEGVLVYGATRGDGEVGEEVTQNLLTIPTIPRRLKGVPERLEVRGEVYMPIEAFLRLNEELEERGERIFKNPRNAAAGSLRQKDPRITAKRGLRATFYALGLGLEEVEREGVATQFALLHWLKEKGFPVEHGYARAVGAEGVEAVYQDWLKKRRALPFEADGVVVKLDELALWRELGYTARAPRFAIAYKFPAEEKETRLLDVVFQVGRTGRVTPVGILEPVFLEGSEVSRVTLHNESYIEELDIRIGDWVLVHKAGGVIPEVLRVLKERRTGEERPIRWPETCPECGHRLLKEGKVHRCPNPLCPAKRFEAIRHFASRKAMDIQGLGEKLIERLLEKGLVKDVADLYRLRKEDLVGLERMGEKSAQNLLRQIEESKKRGLERLLYALGLPGVGEVLARNLAARFGNMDRLLEASLEELLEVEEVGELTARAILETLKDPAFRDLVRRLKEAGVEMEAKEKGGEALKGLTFVITGELSRPREEVKALLRRLGAKVTDSVSRKTSYLVVGENPGSKLEKARALGVPTLTEEELYRLLEARTGKKAEELV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)], Tth DNA ligase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: CIPKP_ARATH
Sequence: MGSKLKLYPLLNHSSVFHPDSRYQSAPTMEEEQQQLRVLFAKYEMGRLLGKGTFGKVYYGKEITTGESVAIKIINKDQVKREGMMEQIKREISIMRLVRHPNIVELKEVMATKTKIFFIMEYVKGGELFSKIVKGKLKEDSARKYFQQLISAVDFCHSRGVSHRDLKPENLLVDENGDLKVSDFGLSALPEQILQDGLLHTQCGTPAYVAPEVLRKKGYDGAKGDIWSCGIILYVLLAGFLPFQDENLMKMYRKIFKSEFEYPPWFSPESKRLISKLLVVDPNKRISIPAIMRTPWFRKNINSPIEFKIDELEIQNVEDETPTTTATTATTTTTPVSPKFFNAFEFISSMSSGFDLSSLFESKRKLRSMFTSRWSASEIMGKLEGIGKEMNMKVKRTKDFKVKLFGKTEGRKGQIAVTAEVFEVAPEVAVVELCKSAGDTLEYNRLYEEHVRPALEEIVWSWHGDNHNNNIVKSNGNYVSDENSGSDC
What is the function of this protein?
CIPK serine-threonine protein kinases interact with CBL proteins.  Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
What are the official names of this protein?
CBL-interacting serine/threonine-protein kinase 25, SNF1-related kinase 3.25, SOS2-like protein kinase PKS25.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: SYT_ALKEH
Sequence: MPAITLPDGSRREFDHPVTVRDVAESIGKGLARAALAGRVDGRLVDLSHRIDDDVQLEIVTDRDPDGVDMIRHSTAHLMAQAVKELFPEAQVTIGPVIENGFYYDFAYKRPFTEDDLKAIEKKMEELARQDFEVHREVWDRDEAIRFFLEQGEQYKAEIIEDLPEHETISVYKQGDFLDLCRGPHVPNTGKLKAFKLQKVAGAYWRGKSDNEMLQRIYGTAWPDKKQLKAYLHRLAEAEKRDHRRIGRAQNLFHLQEEAPGMAFWHPKGWQIYLEVQEYIRRLTRGHGYQEIHTPQLVDRSLWEKSGHWDKFQDNMFITESESRDYAVKPMNCPCHVQVYNQGLKSYRDLPLRLAEFGSCHRNEPSGTLHGLMRVRNFVQDDAHIFCTEDQIQQEVADFIDLVFKAYNDFGFDDVIIALSTRPDERVGEDALWDKAEHALEEALNRAGLEWQLQPGEGAFYGPKIEFTLKDCLGRTWQLGTIQVDFSMPGRLGATYVAEDGSKKVPVMLHRAILGSLERFIGILIEHYAGALPPWLAPVQAVVLNITDRQGEYARRIEKRFRERGLRVDADLRNEKIGFKIREHTLQKVPYMLVVGDKEVENNTVAVRTREGQDLGSMAVDDFLQRLESEIARLGRSNSED
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_SPIOL
Sequence: MVREKIRVSTQTLQWKCVESRTDSKCLHYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSEKIPHEYSTILGIQESVHEILMNLKEIVLRSNLYGTCEASICVRGPRGVTAQDIILPPYVEIVDNTQHIASLTEPIDLCIGLQLERNRGYHIKAPNNFQDGSFPIDALFMPVRNVNHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALYEASRNLIDLLIPFLHAEENVNLEDNQHKVSLPLFTFHNRLAEIRKNKKKIALKFIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKMKHFRIEDVKQIFGTLEKHFVIDLKNKR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRMD_YERPY
Sequence: MWIGVISLFPEMFRAITDYGVTGRAVKNGLLSVQCWSPRDFTYDRHRTVDDRPYGGGPGMLMMVQPLREAIHAAKAAAGEGAKVIYLSPQGRKLDQQGVCELAMNQKMILVCGRYEGVDERVIKTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHHASAEEDSFVDGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLESLALTDEQMVLLAEFQREHKP
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITPA_ASPFU
Sequence: MIPTVKLNFITSNKNKLAEVKAILGNVVEIDSQAIEVPEIQGSIEEIAKEKARRAAEEIGGPVLTEDTALGFRALKGLPGAYIKHFLSALGHDGLNKMLDSFEDRSAEAVCTFAFCRGPGEEPILFQGRTEGIIVRPRGPLNFGWDPIFEHNGMTYAEMDKEEKNRVSHRYKALAKLKQWLEDGTLP
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LOLA_YERP3
Sequence: MKRLLVACCFLSGLISASALADASTDLQNRLSKVNSFHASFSQAVTSSDGAVVQEGEGELWVKRPNLFNWHMTSPDESVLISDGETLWFYNPFVEQATATWLKNATGNTPFMLITRNNPDDWKQYNVKQKGDDFELTPKSASGNLKQFAISVTPSGTIKSFTAVEQDGQRSAYTLKSQQSSVVDASKFTFTPPKGVTLDDQR
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NRX2B_HUMAN
Sequence: MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTTHHVHHFHSKHGTVPIAINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
What is the function of this protein?
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
What are the official names of this protein?
Neurexin-2-beta, Neurexin II-beta.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GLGC_CUTAK
Sequence: MAKTRPKVLSIVLAGGEGKRLMPLTMDRAKPAVPFGGTYRLIDFVLSNLANSGLTQIAVLTQYKSHSLDRHISITWRMSTMLGSYVTPVPAQQRLGPRWYQGSADAIYQSLNLINDQSPDYVVVFGADNIYRMDVDAMLQYHIDSGLGCTVAGIRVPRKDASAFGIIDADQNHKITEFLEKPADPPGLPDASDESFASMGNYIFSREALVQALHDDAHSADSRHDMGGDVIPRFVNAADAQVYDFRDNEVPGNTEKDADYWRDVGTIDAYHDAHMDLVSVEPEFNLYNPDWPIWTMQEQAPGAKFVMRGSCDDTLVSAGCIISGTDIYRTVLGPRARIERWARVDESIVMNNVAIGSNATVHRAILDKNVIVPDGAQVGVDHDHDRARGFTVSPGGVTVVGKGITVPY
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: LAIR1_HUMAN
Sequence: MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH
What is the function of this protein?
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells.  Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11.  It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.  May also play its inhibitory role independently of SH2-containing phosphatases.  Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.  Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion.  Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.  Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
What are the official names of this protein?
Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NOS3_HUMAN
Sequence: MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP
What is the function of this protein?
Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
What are the official names of this protein?
Nitric oxide synthase, endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.