PharMolix/UniProtQA huggingface dataset:
Protein: H2B1H_MOUSE
Sequence: MPEPAKSAPAPKKGSKKALTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 1-H, H2B-clustered histone 9, h2B-221.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RPOB_LEIXX
Sequence: MAAARNATNNDKTLKNGRDVSRLSFAKITDTLTVPDLLALQTESFDWLVGNDAWQARVAAAEAQGRQDLPAATGLEEIFEEISPIEDLGETMQLSFTNPFLEEKKYSIDECKEKGRTYAAPLYVEAEFMNHLTGEIKTQTVFMGDFPLMTERGTFIINGTERVVVSQLVRSPGVYFEAAADKTSDKDIYSARVIPSRGSWLEFEIDKRDQVGVRIDRKRKQSVTVFLKALGLTSEEILAEFAGFQSIELTLEKDAILTKEEALKDIYRKLRPGEQVAAEAARALLDNFYFNPKRYDLAKVGRYKINRKLGLEAPLTDSVLTVQDIIATIKYLVSLHDGQTSFTGLRSGVETDIRLDIDDIDHFGNRRIRAVGELIQNQVRTGLSRMERVVRERMTTQDIEAITPQTLINVRPVVAAIKEFFGTSQLSQFMDQNNPLAGLTHKRRLSALGPGGLSRERAGVEVRDVHPSHYGRMCPIETPEGPNIGLIGSLASFARINSFGFIETPYRKVVDGLVTDQIDYLTASEEDDFVVAQANAPLDARGHFVEERVLARQKGGEVDLVPAEEIGYMDVSPRQMVSVGTSLIPFLEHDDANRALMGANMQRQAVPLLRSESPVVGTGMEGYAAIDAGDVVIAEKSGIVSEVSADAVTVQADDGTVKTYYLRKFDRSNQGTSYNHRVVVDEGDRIEAGEVVADGPATENGELALGKNLLVAFMPWEGHNFEDAIILSQNLVKDDTLSSIHIEEYEVDARDTKLGKEEITRDLPNVSPDLLADLDERGIIRIGAEVRPGDILVGKVTPKGETELSAEERLLRAIFNEKSREVRDTSLKVPHGEEGTIIGVKVFDAQDGDDELGSGVNQRVVVYIAQKRKITAGDKLAGRHGNKGVISKILPVEDMPFLADGTPVDVILNPLGVPGRMNFGQVLEIHLGWIAKNGWEIKGKPKWAAELPETAFSAAPNTKVATPVFDGAKEEEIAGLLDVTLPTRDGDRLIGSSGKTQLFDGRSGEPYPDPVSVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYALQELLTIKSDDILGRVKVYEAIVKGENIQEPGIPESFKVLIKEMQSLCLNVEVLSADGQAVSLRDADDEAFRAAEELGINISSRFESSSIDEI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: Y163_SYNY3
Sequence: MTVMLSCLTQQQELLQSLADRVGQPAIQDNLYFCLAGQFTWVEDWYTTAIAGDVLIFDAGEKEQLARVLQQWEQFTGHVILITGLTEEPDPQTFLTQLALGKQQRCGERHFHWIVLVDPTIEEAFRGLQTFLDGKSHWLDLRLGVGDLEQCTDELWQCVWLEPSPLAPEKRQEMLVNLPHWLAEIVDQKQNLELEPISLLQAKLSLLQGLARESRGEMGRKQAQCHYRESLDVWELLGDTEAIIWLSLRLGYLFLLQAYGEKSRGHQLWQQTRNYAQTAIAALENQQWHFTHGETLNLLGEILRGLEDWEQLRQAAENSLIFFYQLSPFAATDTTPERNQEKLWTELELQGLISLAHSYLCEALVEQWKFDEGKEALKRAFETRPKQVEERDYRPCLANLHYLAGRVQLANDQIRESLMTLRQAQTLVSFEDNPRLYLAILVELRECYLQLEDWLAALAIDQEYQAREYRLGQRAFIGPKPLPCWPEQRICRHPLAPEKMLGGGAEARSAVQSKTMVSLTWQDLQKVWEQKPTPVLVLTGEPGVGKTSWLAGEVLQQMSPERVLLVDFTPHWAEKLWVHLGESFSLPSLGQATTPELVSALQALPILDLLLVLDGENGSLPWQKSPSLRQQELAQVLWQWLLTTSPSQGVRLLISVPPTAIADLYEELKGQLGEEHSLPPLQYQTLSPPTLGQAENWLTQAMAQCRHPWPPSLQSQFLGDLAMEGNGEQQPWLHPIDLQLLGTVLEQEQVTKSADYQGKKLDEWLTLAVQTYLAFLPPHLLKKALQLLKSLADGQQALCLKTEYQLLAALYSAPEPAADNPPEFAQEDIQQLQLLLTLLLRGRLIIVISQATLPYYRLSTTHLAHALQGKSAVISTPALINAGRRGSKSNPNLIAPSPGDRQQGNEDLIAELEAGSSAEEQVVAQKLKAAQLQYQKLVAGINLEKQCQFILKQFLVYPLEALLAAVKTGQDLQKLVTPETPLVQYPSLAPWLSLHSILARINECNRCHHEGPVTVLRISPSMENTPPLVLTATTNGIAYLWSFHGELINVLRGHQEAITALDWSADGQYFATASADHTVKLWQRHGEEVATLRGHEDWVRSVHFSPHHQFLVTSGQDNTARIWNFAGEQLTLCQGHADWVRNAEFNCHGQILLTASRDGTARLWDLEGREIGLCQGHTSWVRNAQFSPDGQWIVTCSADGTARLWDLSSQCFAVLKGHQNWVNNALWSPDGQHIITSSSDGTARVWSRHGKCLGTLRGHDHNIHGARFSLDGQKIVTYSTDNTARLWTKEGTLLTILRGHQKEVYDADFSADGRFVFTVSADQTARQWDISQKDTITLTGHSHWVRNAHFNPKGDRLLTVSRDKTARLWTTEGECVAVLADHQGWVREGQFSPDGQWIVTGSADKTAQLWNVLGKKLTVLRGHQDAVLNVRFSPDSQYIVTASKDGTARVWNNTGRELAVLRHYEKNIFAAEFSADGQFIVTASDDNTAGIWEIVGREVGICRGHEGPVYFAQFSADSRYILTASVDNTARIWDFLGRPLLTLAGHQSIVYQARFSPEGNLIATVSADHTARLWDRSGKTVAVLYGHQGLVGTVDWSPDGQMLVTASNDGTARLWDLSGRELLTLEGHGNWVRSAEFSPDGRWVLTSSADGTAKLWPVKTLPQLLSQGGQWLKNYLTHNALVSPADRPGAKVT
What are the official names of this protein?
Uncharacterized WD repeat-containing protein sll0163.
Protein: TNNI3_HUMAN
Sequence: MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES
What is the function of this protein?
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
What are the official names of this protein?
Troponin I, cardiac muscle, Cardiac troponin I.
What is the protein family that this protein belongs to?
Belongs to the troponin I family.
Protein: SR45A_ARATH
Sequence: MGKREIHFTPVGRQVQRVLEYPLRLENRSPMSYSRRSRYSPSLSPYDKRRGRSVSRSLSRSPTRSVSSDAENPGNSLYVTGLSHRVTERDLEDHFAKEGKVTDVHLVLDPWTRESRGFGFISMKSVGDANRCIRSLDHSVLQGRVITVEKARRRRGRTPTPGKYLGLRTARGRHKSPSYSPRRSVSCSRSRSRSYSSDRGRSYSPSYGRRGRSSSYSPFYRRRRFYSPSRSPSPDDRYNRRRDRSYSPYYRRRDRSRSYSRNCRARDRSPYYMRRYRSRSRSYSPRYRARDRSCSPYYRGRDRSYSPHYQGRDRSYSPESRYYRRHRSVSGSVSPGGRSMSRSISPRKGRKESRSKSRRHDRQSSMCHSRSARSSTSRSVSP
What is the function of this protein?
Probable splicing factor involved in constitutive and/or alternative splicing events.  May bridge the 5' and 3' components of the spliceosome.
What are the official names of this protein?
Serine/arginine-rich splicing factor SR45a, At-SR45A, AtSR45a, Protein TRANSFORMER2-like, atTra2.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family. SR45 subfamily.
Protein: ATRAP_HUMAN
Sequence: MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY
What is the function of this protein?
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation.  Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
What are the official names of this protein?
Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Protein: Y5950_ASPFU
Sequence: MHSLQSFLFLLLLGYGVFAAPTSPQAQSQGRSFKVERIKRGNSIHGPTALRRAYRKFGIVPTTFGVDLSDFVPFNTTSISGTAANLVTDVQEPEQTGAVSAQSVQNDAAFVSPVTIGGQKIVMNFDTGSADFWVMNTELPASAQVGHTVFDPSKSSTFKKMEGATFEIKYGDSSFANGGVGTDTVDIGGATVTGQAIGIPTSVSNSFVEDTYSNGLVGLGFSSLNTVQPQQQKTFFDNIADSLDKPVMTAHLKSDGVGEYEFGIIDQTKYQGDMINVTVDSSGGFWQFQSAHYKVGDGPIQTIQNNAVAIADTGTSLMLLDDTVVNAYYAQVKGAQYASSAGGYIYPCNTELPNLAVAVGAKHLATVPGTFLDFAEVGINKTTGQTVCFGGIQSNQGTSMQILGDVFLKAFFVVFDLRGPSIGLASPK
What are the official names of this protein?
Putative aspergillopepsin A-like aspartic endopeptidase AFUA_2G15950.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RISB_ANADF
Sequence: MNVYEGSLVATGLKVGLVVARFNSLVTEQLLVGAADALRRHGVKDGDIDVFRCPGTFELPALLRRVARSARYDAVVALGAVIRGGTPHFEYVAGEATKGVAQIALESDCAVSMGILTCDTLEQALERAGVKAGNKGAEAAVAAVEQANVLREAAKVPSPRRAE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: LON_BRUSU
Sequence: MTGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQILLATQKNAADDDPAPDAIYEIGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDYHEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKISPEVVGAASQIDDYSKLADTVASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEATVVRNYLDWLLSIPWGKKSKVKQDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKGPILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEAEIRGHRRTYIGSMPGKVIQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFVTTANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALRNVIRHYTREAGVRSLEREVMTLARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQIDGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLRGRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHTLVRQPEPIEWTEQENPTAVPPVEDEAGASLAH
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFP13_MOUSE
Sequence: MSADSQSIAATENEEKSHEVPGNVQHCGDMLSGQEETVPLGTSQESTHIKAEPEEPHSEGASREDRTPGTQRWMSPCPGPKDKGPFLPGGVVPSPWTPVLSRGGRTRERKMAAALLTAWSQMPVTFEDVALYLSQEEWGRLDHTQQNFYRDVLQGKNGLALGAVEMGKVVPALAVATLEDTKSIRTRARWAPGEDPKCGQHVASGPGTKLTRDTGKAGQLKPAPSESRPLKTPEDSGPEKPSEGEEALKSGEEGLVPDGDTGKKTYKCEQCGKGFSWHSHLVTHRRTHTGEKPYTCTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICSKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALTAPPPAST
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 13, Zfp-13, Zinc finger protein Krox-8.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BAZ1B_DANRE
Sequence: MAPLLGRKPYPLVKPLSEPPGPGEEVYTIEHTKEAFRNKEEYEARLRRYGERIWTCKSTGSSQLTHKEAWEEEQEVTELLQEEYPVWFEKPVLEIVHHNTVPLDKLVDQVWVEILTKYAVGEKCDLMVGNDKTLSVEVVKIHPLENPPEENAEKKMEGACDSPSSDKENASQENLKKEPQSKEEESRRESLSDRARRSPRKLPTTMKEEKKKWVMPKFLPHKYDVKLVNEDKVISDVPADNLFRTERPPNKEIMRYFIRHYALRLGSGESAPWVVEDELVKKFSLPSKFSDFLLDPHKFLAENPSTKRKSLSSPEGKPRKRLKNVETGTGGEGAKGDKKKNKDSQNIPLSPTIWSHMQVKKVNGSPLKMKNSGTSKKSDEENVLGTPKSSKKQGDKKSSDPKRRRKSGLNKTPNSQRLSKKEDKSLGGAKKPRMKQMTLLDLAKSPAAAGSPKKQRRSSTTGSAKLGKPFPPMALHLLRFYKENKGKEDKKTTLSSLLSKAAKALSPEDRSRLPEELKELVQKRWELLEQKRRWALMSEEEKQSVLKQKRQEVKQKLREKAKERREKEMQVRREMSRRYEDQELEGKNLPAFRLFDMPEGLPNTIFGDVAMVVEFLHCYSGLLMPDDQYPITSIALLEALAGEKAGFLYLNRVLVVLLQTLLQDELAEGYSELDMPLSEIPLTMHSVSELVRLCLRPSDAHEEESARGSDDWQSGADFDDMVSSEFLEKLETAEVFELDPQEKVSLLLALCHRILMTYSVEDHVEAVHQKSAEMWKERVATLKEANDRKRAEKQKRKEQMETKTDGDVLIKAEKKKESTVKKETPKVLPKEEPEPEDMISTVKSRRLMSIQAKKEKEEQERLNKVRMEKEAEEERIRRQKAATEKAFQDAVTKAKLVLRRTPLGTDRNHNRYWLFSDVVPGLYIEKGWVHESIDYSFTLPPEEEPVLTEEEEEEEEVKKEEETEDGEKEDEGSIISASNDISQQGAPSHESSIETTVPKQGQNLWFVCDTPKDFDELLESLHPQGVRESELKIRLQINYQEILHSIHLTKKGNPGLKTCDGHQELLKFLRSDIIEVASRLQKGGLGYLEDTSEFEEFEERVKTLEKLPEFGECVIALQESVIKKFLQGFMAPKQKKKKKTGGEESTTAEEVDDQKKLAEEARVATAVEKWKTAVREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRRKGEDDKLILCDECNKAFHLFCLRPALYRIPAGEWLCPACQPTIARRSSRGRNYKEDSEEEEDSEEEDEEESEEEDSEEEHRNTGHSLRSRKKVKTSSKSKMQKKPAKPASRSASKTDTNPSKTSPKSSAKPKSRAAPSSPVDIDELVRQSSKPPSRKKDVELQKCEEILQKIMKFRHSWPFREPVSAEEAEDYQDVITSPMDLTTMQGKFKSSEYHSASDFIEDMKLIFSNAEEYNQPSSNVLTCMSRTEEAFVELLQKSLPGVSYLRRRTRKRAATPSDNSDDDDDDEEEDERSKKQKNGKQGKKASSKRKVEHSRTEKYQTKQK
What is the function of this protein?
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator.  Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph).  H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.  Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure.  The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes.
What are the official names of this protein?
Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the WAL family. BAZ1B subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase (By similarity).
Protein: RS16_NOVAD
Sequence: MSVSMRLSRGGSKKRPYYKIVVSNSRAPRDGKYLEQVGTYNPLLAKDDENRVRLIEDRVRYWIGVGAQPTDRVARMLDKAGIKERAATNNPQKAEPGKKAKERAEERAEKAREAAEAAAAAAAAPAEEAAAEAPAEAAAEEQTEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ERA_CALBD
Sequence: MAFKSGFVALIGRPNVGKSTLMNYLVGKKISIISPKPQTTRNSIKGILTLEDAQIIFIDTPGVHPPKNKLGEYMVKVSEKTLKEVDLILYIVEAIDNGIGPWDEAIIERLKEVETPKILVLNKSDLASKENIEILKSIFSTKLNFESIVDIAAINGYNCDLLLDKIKELLPEGPKYYLDDMTTDVRESFIVAEIIREKILLNLSEEVPHGVGIAIERFAERENKDILDIEATIYCEKDSHKAIIIGKGGQMLKKIGMQAREELEMIFGIKVNLQLWVKVKKNWRDDISAMKMLGYNLKEV
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: EMAL_CAEEL
Sequence: MSISNGWSSSSIISDVLPEEEFEEVEEDELILNENDRLKFRVDELEKIVVAQRNEILLLQSSTVEILRRLQNLEIQDQSRSPTCSGYSSLPRRISGSKSSYTMSPSHAPPRSSHANSKSLYINGMNNNSEEVSPGPPRHRPPTRGSDGMVNVSVGKSARGSPMRKWVSTHDMKDTDRFRRLSTSSEASTSATMNPIVNSVRRLSTTHRQSSPSLLSLCSVISRSPSTSSILRKNNRTCQFSNGSGHLPIFIGGKTVQVPVPTGYENMDPTMDQDPPTMKVTLKHVYSYRGKDVRSNIEMLPTGELVFFSANLVVLMNITGEDRSQRIYHGHTCDVKCITLHPNKILVASGQSSCHSVEKFQKPEHTSPIDSPEDLVRQLEMEHTEAHVRIWDTIKLTTLMVLNGFEKGICHVAFSKTDSGSLLAVVDDSLKHLMSVWNWQKGKREGEVKASNDVVFECKWHPTIRNLIVLYGKGHFSFFNYDPATGVLVKTVATFEGRDKPKTVLSMCFGENDQVVTGDSNGTISIWDPRTCKTTKQAHSVHPGGVYSLTLAKSGKILSGGKDRMVSEWDLQDLVRTRRPIELPDEKGFPRVILQNGSELIIGTSSNTLLFGNIENSTNLTSLIEGDPGNLTFLLTCSSNQLITSSQCGTLRIWNHIDKKVEFSKKFIDSVECVDVDVTNTHIILGFAAGLWIVMNITKQQTIQEKKEGTAPITAVKFAPSGATFAVATKDPHLTIYRIDASKNLLVIARIHHIPAPIVALDFSSDSQYLRGQSIGAHLLFWTKAGEICDGTSVKDVKWGSSRVKIGFETALVAHSSNGQVTAVAQCEDISACGMENGTIRIYKNPVTSVTAGFVELLGHGRIIKSVAFSNKIQLFSCSPTDNSVFEWCLE
What is the function of this protein?
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
What are the official names of this protein?
Echinoderm microtubule-associated protein-like elp-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EMAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ILVC_STRZJ
Sequence: MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNAKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SPED_PECAS
Sequence: MHKLKLHGFNNLTKSLSFCIYDICYTKTADDRDGYIAYIDEQYNANRLTEILTETCSIIGANVLNIARQDYDPQGASVTILVSEEPIDPRDVDTSEHPGPLPNSVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGVKHFIDHQINSVQNFMSEDMKSLYHMMDVNVYQENIFHTKMLLKDFDLKHYLFNVNPEELSAAERKRITDLLYHEMQEIYYGRNLPVL
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: PURA_DROAN
Sequence: MSESSAINGNHYEQLHQGRTKMYKSKVAVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSDKFKSIVATHVRLFPSINVDVEAELARYKDYAEKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEIGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICITKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAELGAIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLESELSVPVRWVGVGKGRESIINVH
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD1_LACJO
Sequence: MTNIINGRQIAKQLNQETKTRVDKLKEEGIIPGIVVILVGDDPASVIYTRNKQKNAEKLGMKSILRKFPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKHLNQTELIEAIAPEKDVDGFNSKNVGKLYNNEEGHYPVSCTSRGIMTLLHTYLDKIEGLNVTIVGRSILVSRPLQSLLINENATVTMVSLHTDNIDYYTKHADILVVAAGKPNLIKKDQVKPGATVIDVGINRMANHYLVGDVDFDDVKEVAKNITPVPGGVGPMTIATLMQQTVDLAEWNK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LPXD_PARPJ
Sequence: MAFTLEDIVQRFGGEVVGDGSQRVGSLAPLDQAGPDQLAFLANPKYLAQVETTRAGAVLINADDLAKLASRENRNFIVTPNPYAYFARVAQTFIDLAAPKAAPGVHPSATIDPSAQIAASAVIGPHVTVEAGAVIGDNVRLDANVVIGRGTRIGAGSHLYPNVAVYHGCKLAERVIVHAGAVIGSDGFGFAPDFVGEGEARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEECVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTAKSGVSKSLLKPGMYTSAFPAVNHADWNKSAALLRNIDKLRDRIKTLENAAAEKRDGPAPNAASKATGDKV
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: INO1_CRYNH
Sequence: MSPTALDACDHHDSFSLPAQDQSKVHPSARRTPEGGLIKVESDSTVYEADGIKAKFTDRGASVIKGSDGKLSVKKTEKNFEFFTKSTVGRVGLMLVGLGGNNGTTVLATNLANKYNISWHTKNGIQQPNYIGSVVRASTVRLGTDPETGKDVFVPISDMLPMVHPNDFVIGGWDISSLSMDKAMLRAKVLEWDLQRQLIPLMENVKPLPSIYYPDFIAANQADRADNLIPGDDKKVHLEHIRADIRRFKADNHLDSVVVLWTANTERYADIIPGVNDTADNLLKAVETSHEEVSPSTIFAMASILEGVPFINGSPQNTFVPGCIELAEKHKAFIGGDDFKSGQTKVKSVLAEFLVNAGIKPLSISSYNHLGNNDGKNLSSQRQFRSKEISKSSVVDDMVAANPILYKTAEDLSKATGEIVKKGEHPDHIVVIKHVPAVGDSKRAIDEYYSELLMGGRNVMNIFNECEDSLLATPLIFDLAILAELLTRVTYRENATGEWQPLYSVLSLLSYMLKAPLVKPGEDVVNSLNRQRNALEQFLKACLGLEHSNDLLLNTRVW
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:21398509).  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
Protein: NSF2_DROME
Sequence: MSIEKAHRMRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQRKWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDMIRQSEPHQRVIKFLSKMEEEGGLEMDRVQGH
What is the function of this protein?
Required for vesicle-mediated transport.  Catalyzes the fusion of transport vesicles within the Golgi cisternae.  Is also required for transport from the endoplasmic reticulum to the Golgi stack.  Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity).
What are the official names of this protein?
Vesicle-fusing ATPase 2, N-ethylmaleimide-sensitive fusion protein 2, NEM-sensitive fusion protein 2, Vesicular-fusion protein NSF2, dNsf-2, NSF-2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y871_TREPA
Sequence: MSAYRYANLTNTKYIPSVYAVMATAGCDDRKIKRKEKGKRHAAPLSLMGVHKR
What are the official names of this protein?
Uncharacterized protein TP_0871.