PharMolix/UniProtQA huggingface dataset:
Protein: ALBA_SULAC
Sequence: MSSGATPSNVVLVGKKPVMNYVLAALTLLNQGVSEITIKARGRAISKAVDTVEIVRNRFLPDKIEVKEIRIGSQVVTSQDGRQSRVSTIEIGIRKKA
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: METE_STAAE
Sequence: MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHYIVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFERAHLKFLSSLPVGGIGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKKVLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQNDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRSEYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: PAX6_HUMAN
Sequence: MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
What is the function of this protein?
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas.  Required for the differentiation of pancreatic islet alpha cells (By similarity).  Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters.  Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).  Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).
What are the official names of this protein?
Paired box protein Pax-6, Aniridia type II protein, Oculorhombin.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus.
Protein: PHNXW_CLOD6
Sequence: MKKIYGEKIKAVVFDWAGTTVDYGCFAPLNVFIEIFKRRGIDVTMEEARKPMGKLKIDHIREMCEMDRIKNIWSDKFGKVPTEDDVNELYAEFEPMLFETLEEYTTPIPHVVETIEKLRKNGLKIGSTTGYTREMMNIVEPNAAKKGYSPDFLVTPSEVSQGRPYPWMCYKNAEALGVSPMSSMVKVGDTISDVKEGVNAGMWSVAVIKGSSELGLTQEEVENMDKEELKAKMSIVSKKFKEAGAHFVIETMAELEDILIKIENETIKSDFVPENDYILLTPGPLSTTKSVRASMLKDWCTWDVEYNNLVQDVRRRLVSLATQNTDKYTSVLMQGSGTFSVEAIIGSTISKDGKLLVIANGAYGKRMKDICNYLNIQFVDCTFKDIEAVDLNVVENLLKENKDITHISMVHCETTTGRLNPIQEVGKLAKEYNKIYIVDAMSSFGGIEIDVEDFNIDFLVSSSNKCIQGVPGFGFIIANKEELSKCKGIAKSLSLDVYAQWDTMEKNNGKWRFTSPTHVVRAFYQALLELEEEGSVEKRYARYKENQFTIASRLKSLGFDTLVNDNAQSPVITTFLYPKNAKFEFMEFYTYLKDNGFVIYPGKLTDIDTFRIGSIGEVYPTDMERLADVIEKFINR
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Bifunctional phosphonoacetaldehyde hydrolase/aminoethylphosphonate transaminase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: THIO_PORPU
Sequence: MSVSQVTDASFKQEVINNDLPVLVDFWAPWCGPCRMVSPVVDAIAEEYESSIKVVKINTDDNPTIAAEYGIRSIPTLMIFKSGERVDTVIGAVPKSTLESTLNKYIS
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MINC_PSEAE
Sequence: MSQADLLDQDPVFQLKGSMLAVTILELAHNDLARLERQLADKVAQAPNFFRDTPLVMALDKLPEGEGRLDLPALLEVCRRHGLRTLAIRAGREEDIAAAQALDLPVLPPSGARERPLDIKDSAPRKPAEEPSPSAGEARPEPAKAEEKPAEPVSRPTKVVKTPVRGGMQIYAAGGDLIVLAAVSPGAELLADGNIHVYGPMRGRALAGVKGDATARIFCQQLAAELVSIAGNYKVAEDLRRSPQWGKAVHVSLSGDVLNITRL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PG056_VAR67
Sequence: MLNRVQILMKTANNYETIEILRNYLRLYIILARNEEGHGILIYDDNIDSIMSMMNITRLEVIGLTTHCTKLRSSPPIPMSRLFMDEIDHESYYSPKTSDYPLIDIIRKRSHEQGDIALALKRYCIENTDSISEINEWLSSKGLACYRFVKFNDYRKQMYRKFSKCTIVDSMIIGHIGHHYIWIKNLETYTRPEIDVLPFDIKYISRDELWAQISSSLDQTHIKTITVSVYGAITDNGPMPYMISTYPGNTFVNFNSVKDLILNFLDWIKDIMTSTRTIILVGYMSNLFDIPLLTVYWPNNCGWKIYNNILISSDGARVIWMDAYKFSCGLSLQDYCYHWGSKPESRPFDLIKKIDAKRNIKSWVKESMTSLKSLYEAFETQSGALEVLMSPCRMFSFSRIEDMFLTSVINRVSKNTGMGMYYPTNDISSLFIESSICLDYIIVNNQKSNKYRIKSVLDIISSKQYPAGRPNYVKNGTKGKLYIALCKVTVPTNDHIPVVYHDDDNTTTFITVLTSVDIETATRAGYSIVELGALQWDDNIPELKDCLLDSIKMIYDLNTVTTNNLLEQLIENINFNNSSIILLFYTFAISYCRAFIYSIMETIDPVYISQFSYKELYIRSSYKDINEVMSQMVKL
What is the function of this protein?
Plays a role in intracellular enveloped virus (IEV) transport to the cell surface through microtubule transport.  Together with protein OPG064, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.
What are the official names of this protein?
Protein OPG056, Protein F12.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG056 family.
Protein: BST1_ASPTN
Sequence: MHRRSSGSPVEDDAEDPLISRTPSEPSGPNAVEPSERARPQVARTGTSFDLRRDHTGASTPRSRNSSTWRMPSSATTTLLPPDPRSSSAAMPLTSQRLLAEASPDAQSRSRPARLRSPWPCSILTALTSLLASLFLCAILRSFAARQTGGDGCGIPVMSPAFLHMAGFDTEHTRFASKYNLYLYREQGVDPFNHENLGLNGAPVLFLPGNAGSYRQVRSLAAEASRHYFEVVRHDQERLRSGTRSLDFFMIDFNEDMAAFHGQTLLDQAEYVNEAVAYILSLYHDPKRSRRDPELPDPSSVIIIGHSMGGIVARTTLTMSNYQANSVNTIITMSAPHAKPPVSFESDVVHTYKQINDYWREAYSQTWANNNPLWHVTLISIAGGSRDTVVPSDYASISSLVPETHGFTVFTSTIPDVWIGMDHLSITWCDQFRKAIIKSLFEIVDVRRASQTKPRAERMRVFKKWYLTGLEPIAERTLSQKEPNTLLTLEDQSNTILPQGQRLILRELGHRRSPNVHLLPVPPQGVAGKKFTLLTNQRFDKSGEQGTLEVLFCSVFPLQNGKFSTVFTMNMDFSGGNVGSTRLACKNAAEDAIHLPASTHFSKHPYDRAEPFSYLQYDLEDLAEHQFVAVVDKAQSPTKGWLLAEFSDSSDAVIRARLGLGGLLSAGLKMRLPANRPMLTEVKIPALYSSLLDYNLKIVRRNHGNQQELFTPLLRQSIPDPHESKFFVNVKDVNVNLHGVAPFMPPPLREQAAVGGVSFQLWTDPSCDSTVDISLHVDIASSLGELVMRYRTVFAAFPILVVALVLRKQFQVYDQTGYFITFTEGLDSALRSSLPMLLLAMSLLASSLATSSRLPPSDDPFHWPLNSTESPIDFTKNDLLLGSQDAFFWFLVPLFGLICVGVCVILNYIALALLSVLAFFYGIFKSKSGYIKRDDKRLVPGFHSTSVTVTNEASNLPIFSAPTPRKRMINTAILLLLVSTTIPYQFAYLVACIVHLATCVRAQWHAKETKSTTHYNFFNYTHSIFILMLWILPINILVLLVWAHNLVVHWFMPFSSHHNVLSIMPFILLVEAMTTGTMIPRVTTRFKYITSLILFSIAIYAAVYGVSYAYLLHHLANIFAAWLVGVYFFSSGFSVRRLWRVLEGDEGTSNSEPGSMKKKP
What is the function of this protein?
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
What are the official names of this protein?
GPI inositol-deacylase.
What is the protein family that this protein belongs to?
Belongs to the GPI inositol-deacylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS17E_HALS3
Sequence: MAIKPDYVKKTGNILMERYQDAFSREDFEHNKDAVTELTNIESKNVRNRIAGYITHKRN
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: HXK4_MOUSE
Sequence: MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:8530440).  Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity).  Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:8530440, PubMed:9867845).  Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (PubMed:8530440, PubMed:9867845).  In pancreas, plays an important role in modulating insulin secretion (PubMed:8530440).  In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (PubMed:9867845).  Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:9867845).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity).
What are the official names of this protein?
Hexokinase-4, HK4, Glucokinase, Hexokinase type IV, HK IV, Hexokinase-D.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus.
Protein: BTUF_VIBC1
Sequence: MMNKLCFALPLIFSDASFANGPAQRIISLAPHSTEIAYSAGLGDKLIAVSEMSDYPEQAKDLEKVSNYQGIKLERIIALQPDLVIAWPAGNPAKELEKLEQFGIPIYYSTTGTLEGIATNIEQLSQYSEKPEVGQKAAAEFRAQLEALKEKYNTEDKVSYFYQLSEKPIITVAGKNWPSEVFTFCGGENIFSKGSAPYPQVSIEQVITRQPEVLFASRHAMSNDGMWAEWKNDIPALGNNHVWSLNSDWINRPTSRTLNAITEVCEHFETVRQKR
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
What are the official names of this protein?
Vitamin B12-binding protein.
What is the protein family that this protein belongs to?
Belongs to the BtuF family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YTM1_ASPFU
Sequence: MNDGSNSDATATSSAAQRQVRVQLTSKQEDIALPDNTGPILVPTSLRRYALSTLVNKLLGNDKPIPFEFLINGTFLRTSIDEYLTANGISAETTLEIEYVRALIPPLHIASFQHDDWVSSTDVLSATSPAATWASATISQGQEKILSGSYDGLLRVWNMSSQIVATSPAAADGGHTASIKAAKFVTPNQIASAGLDRTVRLWKYAESDEGFSGTIAPQLELYGHKSGINSLAVHALSNRILSASSDNSVGFWSTKKSDAPAAPDDLLPSAASRSSKRRKLNSSVTVPQRGPLALLSSHTAPVSAAIFDAKDSTVGYSASWDHSMRTWDLVTSALVDTRTTSHSLLSLEHLPELNLLAAGTSARHITLIDPRASATTISAMTLRGHTNAVVSLARDPHSTYGLISGSHDGTCRIWDIRATKTDKDGAVGESVYSISRKSLEEQGRSDTKRVGGEGVKVFSVCWDKTVGIVSAGEDKRIQINRGEGVLSA
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ytm1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RL7_ECO27
Sequence: MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CLPS_BURCM
Sequence: MAIIPDKQDSTVLERKQQKLKPPSMYKVVLLNDDFTPMEFVVMVVQEYFKKDRETATQIMLKVHREGRGVCGVYTRDIASTKVEQVVTHARQAGHPLQCVMEEA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: SCFD1_DICDI
Sequence: MNQNSSLSSSGMMGSGGFGFDQFSNNFSIKTKQIESINKMLSLKSESSSSNNNNNNNKAISGWQEVWKVLIFDTHCSNIIAPILTKGALRNQGVTLYLPLHSDRQPIQDVPAIYFVLPTSDNIKRIAEDCKNKLYDNIYLNFASKLSNQLMEELATLTIQSDSVSMISKVYDQFLNFISLENDLFVLNNPRDSYLSFNDTRIKDTQAQENIDMVVDSLFSVLVTLGVVPIIRAPKNSAAEMIALALEKRISTTLQSSGGSNVFSNMNEMGSQLSSFYRPVLILLDRNVDLSVCLHHPWTYQALVHDVLNMSLNQVRIDVTQNGQTSKKSYGLDSSSDSFWSSNTGAAFSSVAGEIKSQINEYYQQMEKLQQITDIKLDDSDDFDNNNKKSNENKTKGLGNLVQEMDEKKRLIDIHTNLATDLTKNIRDRQIDCFFAMEESIITRSLTDKKELHSLITSPIVGETGGRGTLEDKIRLLIIYFLSTKNVPQSEMDQYEDALTKMGADLSTLDFFKKTKAFNESLTAIANVNQSSTQSSNTASGKIGGFMQMMTSVTGYQGVESFTNFFQQGVRALLPKSKDLFVTRIVESIMDLKNTLDADYLYLDPKIQNKSNVPKRTTPFKEAIVFTVGGGNYVEYQNLQDFSKKHNKKIIYGSNELLTSKEFLNQIKNLNKN
What is the function of this protein?
Involved in vesicular transport between the endoplasmic reticulum and the Golgi.
What are the official names of this protein?
Sec1 family domain-containing protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Protein: SPED_XANOR
Sequence: MVKPLPRLRLQGFNNLTKALSFNIYDVCYARTEEERQRYIEYIDEQYDADRLTQILTDVAEIIGANILNIARQDYDPQGASVTILISEEPVIDKKQAGRELISDAVVAHMDKSHITVHTYPETHPQEGIATFRADIDVATCGVISPLKALNYLIETLESDIVIMDYRVRGFTRDVKGKKHYIDHKINSIQHFLAKNVKSRYEMIDVNVYQENIFHTKMHLKDFDLDQYLFEERAKNLSFKERMKIETLLKREIEELFHGRNLSE
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: NSRI_ASPN1
Sequence: MTKTVPPKTPAYEDTVGCQIALFEWAESYDTKDWGRLAKCIAPTLRIDYRNVIGKLWEAMPADEFLAMASSEKFLGNARIKTQHFVGAGKLVQTHEDRITGYHQMRVAHQRYSDDALTEVLYTGHGHGKATVQFCLVDGVWKFAGLEPEIRWAENDLEKIFE
What is the function of this protein?
Scytalone dehydratase-like protein; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin, which exhibits antibacterial activity (PubMed:30394754, PubMed:32105084, PubMed:33891392).  The two different monomeric units appear to be synthesized by the same set of enzymes, among which the Baeyer-Villiger monooxygenase nsrF is the key enzyme for the divergence of the biosynthetic routes (PubMed:32105084).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase nsrB (PubMed:32105084).  The atrochrysone carboxyl ACP thioesterase nsrC then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (PubMed:32105084).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase nsrE, and oxidized by the anthrone oxygenase nsrD to yield emodin (PubMed:32105084).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase nsrR (PubMed:32105084).  A-ring reduction by the short chain dehydrogenase nsrJ, dehydration by the scytalone dehydratase-like protein nsrI and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:32105084).  The Baeyer-Villiger monooxygenase nsrF accepts chrysophanol as a substrate to insert one oxygen atom at two different positions to yield the precursors of both monomric units (PubMed:30394754, PubMed:32105084, PubMed:33891392).  NsrF is promiscuous/flexible in interacting with the 2 (non methylated and methylated) aromatic rings of chrysophanol, thus diverging the biosynthetic pathway at this point (PubMed:30394754, PubMed:32105084, PubMed:33891392).  After the hydrolysis of the lactones, methylesterification by the methyltransferase nsrG yields respectively moniliphenone and 2,2',6'-trihydroxy-4-methyl-6-methoxya-cyldiphenylmethanone (PubMed:30394754, PubMed:32105084).  The next steps are the hydroxylation by the FAD-dependent monooxygenase nsrK, followed by isomerization by the monooxygenase nsrQ (PubMed:32105084).  The short chain dehydrogenase/reductase nsrO then catalyzes the C-5 ketoreduction to give the xanthone skeleton of blennolide C and 5-acetylblennolide A (PubMed:32105084).  The acetyltransferase nsrL has a strict substrate specificity and uses only blennolide A but not blennolide C to yield 5-acetylblennolide A as the single-acetylated product (PubMed:30394754).  In the final step of the biosynthesis, the heterodimerization of the 2 xanthones, blennolide C and 5-acetylblennolide A, is catalyzed by the cytochrome P450 monooxygenase nsrP (PubMed:30394754).  NsrP can utilize at least three different xanthones as its substrates to perform the dimerization reaction (PubMed:30394754).
What are the official names of this protein?
Scytalone dehydratase-like protein nsrI, Neosartorin biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
Protein: RECA_BDEBA
Sequence: MANATVDNKANSEKIKALELAVSTIEKQFGKGSIMRLGANESLVKDVEAISTGALSLDIALGIGGLPKGRICEIYGPESSGKTTLCLSVIAQAQKKGGVVAFVDAEHALDINYARKLGVNTEDLLISQPDTGEQALEITETLVRSGAIDVLVVDSVAALVPRAEIEGDMGDSHVGLQARLMSQALRKLTAAINRSNTLVIFINQIRMKIGVMFGNPETTTGGNALKFYSSVRLDVRRVGAIKNGEDVTGNRTAVKVVKNKMAPPFTKVEFDLMYGEGISEEGDLLDLAVTANMVEKSGAWFSINGERMGQGRDAAKNFLKEHPEYMVELRKKILAANGIGKLLVDTNGNNGEDHEGTEPVEIEAEDAAPKKGKKGKH
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_MYCTO
Sequence: MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVSEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: AMIF_HELP2
Sequence: MGSIGSMGKPIEGFLVAAIQFPVPIVNSRKDIDHNIESIIRTLHATKAGYPGVELIIFPEYSTQGLNTAKWLSEEFLLDVPGKETEAYAQACKEAKVYGVFSIMERNPDSNKNPYNTAIIIDPQGKIILKYRKLFPWNPIEPWYPGDLGMPVCEGPGGSKLAVCICHDGMIPELAREAAYKGCNVYIRISGYSTQVNDQWILTNRSNAWHNLMYTVSVNLAGYDNVFYYFGEGQICNFDGTTLVQGHRNPWEIVTGEIYPKMADNARLSWGLENNIYNLGHRGYVAKPGGEHDAGLTYIKDLAAGKYKLPWEDHMKIKDGSIYGYPTTGGRFGK
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: MTNC_METCA
Sequence: MIRAILTDIEGTTSSLSFVKETLFPYARARMADFVRGHARDATVQALLADAKAAAGDPSMDDEHVIARLVRWIDEDRKITPLKALQGLIWEEGYRNRDFFGHVYDDAVRRLKAWHEQGISLYVFSSGSVHAQRLLFGHTAAGDLQPLFSGYFDTRIGAKQEPAAYSAIARELNLPPSEILFLSDIEAELDAAREAGYKTFMLVREGGAKASHHPQGADFDAIRPELL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.