PharMolix/UniProtQA huggingface dataset:
Protein: YMF27_MARPO
Sequence: MASLFSTFRTQTFLYPAHTFIYPAHTFSHFGPAFFGQALHLFGPGLGLFERENAHCHIFDNRKTPPRLQ
What are the official names of this protein?
Uncharacterized mitochondrial protein ymf27, ORF69.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FUS6_GIBM7
Sequence: MPQPDKMAAVNNAMPQPAPEKSLSSDPQPESSKKSARFWLIFVAIALTTFLAALDTSIISTALPTITADLGSESLYVWIIDAYLLASTATIPIFAQAANIYGRRSLTLIAVCIFTLGSGLCGGAHNTAMMVGGRAVQGIGGGGILTMSEIVVCDMVSIRERGMYAGIIGGVWAIAAVVAPVMGGAFAQNISWRWIFYINLPIAGVSLVALGLFLKLARPPSGTVKEQMSRIDWGGSVLLIGSVTSIVLALSWGGSEHPWSGWQTIVPLVIGLLALVAFFAYQGAPWLREPTMPLRLFGNRTSSTLLVISFIHSLLLYWVCYFLPVYFQAVKEASPTRSAVMLFPIACTSAPAGVAAGITITKTGKYRVWHFTGFVLMSIACGLFTLLDAQSSTGRWVGFQILFGVGTGTVFTSTLPPILASLPDSDVATATGAWTFIRNFGSIWGVAIPAAVFNNQVNHAAPKISDSTVKSLLVDGGAYEHATQHFIKSLSPNPELKTQVIQVYLEGLKVVWQVSLAFCLLGFILCFFVRSLTLRDELNTEFGLKEEKPNSKNMSSEEGVVRE
What is the function of this protein?
Efflux pump; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22652150).  Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (By similarity).  The other FUS cluster members are not essential for fusarin C biosynthesis (By similarity).
What are the official names of this protein?
Efflux pump FUS6, Fusarin biosynthesis protein 6.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: 1003L_ASFK5
Sequence: MGNHLDGSYLPNTVMSIEDKQNTYNEAKEDSKICNKIYIKQSGKIDKKELKRIKKLDFFYSQKNDDEIERMFMNKPNGTFLLTDDATDENLFLVQKDLENGSLNIAKLDFNGKALYINGKNYFSLENYLKTVEDFYKYPLIYDENK
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 100-3L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 100 family.
Protein: RS16_CAMLR
Sequence: MTVIRLTKMGRKKRPFYRIVVTDSRKRRDGSWIESIGYYNPMVEPEVVKFDAERLAYWKSVGAKLSDRVAAITSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SYFB_STAAC
Sequence: MLISNEWLKEYVTIDDSVSNLAERITRTGIEVDDLIDYTKDIKNLVVGFVKSKEKHPDADKLNVCQVDIGEDEPVQIVCGAPNVDAGQYVIVAKVGGRLPGGIKIKRAKLRGERSEGMICSLQEIGISSNYIPKSFESGIYVFSEAQVPGTDALQALYLDDQVMEFDLTPNRADALSMIGTAYEVAALYNTKMTKPETTSNELDLSANDELTVTIENEDKVPYYSARVVHDVTIEPSPIWMQARLIKAGIRPINNVVDISNYVLLEYGQPLHMFDQDAIGSQQIVVRQANEGEKMTTLDDTERELLTSDIVITNGQTPIALAGVMGGDFSEVKEQTSNIVIEGAIFDPVSIRHTSRRLNLRSESSSRFEKGIATEFVDEAVDRACYLLQTYANGKVLKDRVSSGELGAFITPIDITADKINRTIGFDLSQNDIVTIFNQLGFDTEINDDVITVLVPSRRKDITIKEDLIEEVARIYGYDDIPSTLPVFDKVTSGQLTDRQYKTRMVKEVLEGAGLDQAITYSLVSKEDATAFSMQQRQTIDLLMPMSEAHASLRQSLLPHLIEAASYNVARKNKDVKLFEIGNVFFANGEGELPDQVEYLSGILTGDYVVNQWQGKKETVDFYLAKGVVDRVSEKLNLEFSYRRADIDGLHPGRTAEILLENKVVGFIGELHPILAADNDLKRTYVFELNFDALMAVSVGYINYQPIPRFPGMSRDIALEVDQNIPAADLLSTIHAHGGNILKDTLVFDVYQGEHLEKGKKSIAIRLNYLDTEETLTDERVSKVQAEIEAALIEQGAVIR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYT2B_HUMAN
Sequence: MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNYTHDVFMNDSLFCVVAAFGCFYY
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system.  Required for proper retrograde ciliary transport.
What are the official names of this protein?
Dynein light chain Tctex-type protein 2B, Tctex1 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
What are the subcellular locations of this protein?
Dynein axonemal particle.
Protein: RL28_HUMAN
Sequence: MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547).
What are the official names of this protein?
60S ribosomal protein L28, Large ribosomal subunit protein eL28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL28 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTLH_BORBR
Sequence: MNDAAPDRQASVDFHLQALHPWLSRQDIAEICVNRPGQLWYEDRNGWNRQESGALTLDHLHALATATARFCDRDICPERPLLAASLPGGERVQIVVPPACEPGTLSLTIRKPARRIWPLSELLRDALDLPGVPGASQARPDPLLDPWRRGAWDDFLRLAVQAGKAILVAGQTGSGKTTLMNALSGEIPPRERIVTIEDVRELRLDPATNHVHLLYGTPTEGRTAAVSATELLRAALRMAPTRILLAELRGGEAFDFLQACASGHSGGISTCHAASADMALQRLTLMCMQHPNCQMLPYSTLRALVESVIDIVVVVERRAGQGARRRVVDIWYRDGLPAP
What are the official names of this protein?
Type IV secretion system protein PtlH homolog.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
Protein: SURE_ANADE
Sequence: MRVLLSNDDGVHAAGLRALAEAFHGDEVWVVAPDREQSASSHAISLHRPLRLLEVAPRWYAVDGTPTDAVYMGLNLVLRDARPDVVVSGVNHGPNLGNDVLYSGTVAAAMEGALLGVNAVAVSLAAPPPHDFGEAARFAAALARQVVARPPPAPVLLNVNVPPGPVRGYRFTRLGRRTYGNEVVEKTDPRGRKYYWIGGEGRVHNEDIPGSDCNAVLLERLAAVTPLHLDGTHDPMFQELRSWTVPGYEKEPAP
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEN2D_HUMAN
Sequence: MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
What are the official names of this protein?
DENN domain-containing protein 2D.
Protein: RL14_ALKOO
Sequence: MIQQESRLKVADNSGAKELLCIRVLGGTRRKYAHIGDVIVCSVKSATPGGVVKKGQVVKAVVVRTTNTTRRKDGSYIKFDENAAVIIKDDKQPTGTRIFGPVARELRDKNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ASAH1_CAEEL
Sequence: MLRELSVLLLVAVCAAKHVELPAPFKDHCILDDKQNLYDPSKQFDIKWYDVNLDLPPSERWVQIATANKEHIADLIGVLINLITPWFPNAIDFVDDVFGDLAPKLAQPYRDEIFSIANATGIPLGQITMYNIFYEIFTVCTSVIAQDKDGHVFHARNLDFGLFMGWDPVLHDWQISQKLRKMIINVNWLKDGKLLYKSNNFAGYIGIYNGLKPNAFSLTADDRFQLVGGYYGILKWVFGLEADGKWMSWLARETLETKTTYLDAKEHLMNTPMLSPVYFILGGSKKDEGCIIARSLDKTALLTEMATSPHGWYLLETNYDQGTEDLYLDDRDTPGFRCMDKLTQKNVGFEGIFNVLSSRTNLNKLTTYTVLMSVETSRFETILQSCPGECYPW
What is the function of this protein?
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH.
What are the official names of this protein?
Acid ceramidase, Acylsphingosine amidohydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
What are the subcellular locations of this protein?
Lysosome. Secreted.
Protein: RIMM_RICFE
Sequence: MNSLENLILVGVIKSCHGIKGHVILKSFTEPATKILERNLVNESGEDIHIKLISQNTKGELICTFNDIATRNEAENLKGYKLFCLRASLPKLEEDEFYIADLNHLPVLNQDHKEIGKIKNILNFGAGDIIEIEFLDQTTELLPFNKEFIPLITKDYVVLNYQREI
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_WOLWR
Sequence: MDIADIESRSSQELHEILVNLRKEFVNLVFQKKLGQCNNISRFSLIRKSIARILTTLNKRRREEKNA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: QUEA_SYNP6
Sequence: MNEPSPSDWHLDAYDYELPPDRIAQSAVEPRDHARLSVFPDREQLWHRHFYDLPQLLRPGDLLIVNDTRVIPARLYGQKIETGVPVEVLLVEEHGPGYWLTLVKPGKRLKPGSAIAFGPNPEDPLLVADVEASDPATGGRWLRFRGEAEAFWSQLATLGEMPLPPYIHTTASDPERYQTVYSRELGAVAAPTAGLHFTPELLTTLADMGIATAPVTLHVGIGTFRSVDVEDIRQHEMHSERMMVPAATVEKIQATKAAGGRVIAVGTTSVRAIEGAAASGELKPGSDRVNLFIYPGYRWQIIDGLITNFHLPRSSLMMLVSALIGRDRLLSAYATAIAEQYRFYSFGDAMLILPDAKLP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_PROM0
Sequence: MTSSKNPTNDNSYFDAVLVGGGIMSSTLALLISEVLPDIKFLIIEKLNAPGSESTGAFNNAGTGHAANCELNYTPLDEKGNLKIDKALSINRSFETSMSLWASLYEAGKIDIKKFLKFIPHISFVSGQDNISFLKKRFQKMTENPEFIDMEFSSSFDEISSWAPLITKDRNPSTQIAATRIGRGTDINFEALTKEYLSLVSLNKNVEIRYKTELVDLKKIDKKQWELEISSEGRKTSIRTGYVFLGAGGKTINYLQKSKIPEAKSYGGFPVSGKWLICEKKDLTEKHNSKVYGKADIGSPPMSVPHLDTRWIDNKKLLLYGPFAGFTTKFLKQSSYFDLFSSIKKNNIFSMLDVGFKNNDLINYLISQSLKNHNSRVENLKNMMPSANSSDWYLKNAGQRVQIIKKTEAGGSLKFGTEIVNSSDGSLSALLGASPGASTAVSIMVKVLEKSVFFLNDKHNLQKKINDLIYPELSDSENNSTFIKDIKKRNNSIFGFHP
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: TROP_HUMAN
Sequence: MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG
What is the function of this protein?
Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.  Directly responsible for homophilic cell adhesion.
What are the official names of this protein?
Trophinin, MAGE-D3 antigen.
Protein: SYDND_BURMA
Sequence: MRTEYCGLVTEHLLGQTVSLCGWVHRRRDHGGVIFIDLRDREGLVQVVCDPDRAEMFAAAEGVRNEFCIQVKGLVRGRPEGTINAGLKSGRIEVLCHELNVLNASVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQHNLRLRYRVAIEARKYLDEQGFIDIETPMLTKSTPEGARDYLVPSRVNAGQFFALPQSPQLFKQLLMVANFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLGEQEIRDLFEDMIRHIFKTTIGVELDATFPVMPYSEAMARFGSDKPDLRVKLEFTELTDAMKDVDFKVFSTPANTKDGRVAALRVPKGGELTRGDIDGYTEFVRIYGAKGLAWIKVNERAKGRDGLQSPIVKNLHDASIAAILERTGAQDGDIIFFAADRAKVVNDSLGALRLKIGHSEFGKANGLVEAGWKPLWVVDFPMFEYDDEEARYVAAHHPFTSPKDEHLEYLETDPGRCLAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGPEEAQAKFGFLLDALQYGAPPHGGIAFGLDRIVTMMAGADSIRDVIAFPKTQRAQCLLTQAPSPVDERQLRELHIRLRQPEQPKA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1530_RUBXD
Sequence: MGRRYTIKQLPPELRPRERLLAGGASALSDAELLGVLFGIGSREKTAVELAGDVISGAGGLHNLFGASVHELKQVKGIGEAKACILLAALELARRLSVARNPGRPVISSPADVDGLLRGRIANLDREHFVVVLLNTKNEVIEAPTISVGTLSSSLVHPREVFKPAIRASAASVVLAHNHPSGRVEPSREDREVTGRVAEAGGIIGIEVLDHVIVGEGYFSMKEHGML
What are the official names of this protein?
UPF0758 protein Rxyl_1530.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MT10A_MYTED
Sequence: MPAPCNCIETNVCICDTGCSGEGCRCGDACKCSGADCKCSGCKVVCKCSGRCECGKGCTGPSTCKCAPGCSCK
What is the function of this protein?
The metallothioneins are involved in the cellular sequestration of toxic metal ions.
What are the official names of this protein?
Metallothionein 10-Ia, MT-10-Ia.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 2 family.
Protein: CSN8_DANRE
Sequence: MPVCVMMAELDEKLLLQFETQELEAPGGIATPQVYSQLLVLYLLHNDMNNARYLWKRIPQAIKTANPEMAAIWAVGQRIWQRDFPGIYSAIAAYQWSESILPVMEALRESTRRRAYGLVAQAYTSISAEDFAAFVGYSVEEAVKGVVSHGWQADPNTRMIMPQKPDPPPVSLVPNEQQLARLTDYVAFLEN
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 8, Signalosome subunit 8.
What is the protein family that this protein belongs to?
Belongs to the CSN8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FA9_CAVPO
Sequence: RVSIPSVSKEHNRANAIFSRMGYVNFTDDETIWDDNDDDETIWDNSTESTKPSDEFFRVVGGEDAKPGQFPWQVLLNGETEAFCGGSIVNEKWIVTAAHCILPGIKIEVVAGKHNIEKKEDTEQRRNVTQIILHHSYNASFNKYSHDIALLELDKPLSLNSYVTPICIANREYTNIFLKFGAGYVSGWGKLFSQGRTASILQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTNFLTGIISWGEECAMKGKYGIYTKVSRYVNW
What is the function of this protein?
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
What are the official names of this protein?
Coagulation factor IX, Christmas factor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TIM50_ASHGO
Sequence: MLHVIRRSRATSARQLPRVAGLLAGAAAVRSRTYIGTRILHEEQKPKKPEPPNSILTEDMLARAGVDAERGPETEKAPAEDKAGESTETGSGAGKKKRARKTTTEIKRERYANLFYLFSLTGLAGGAVYMSRDWDADEPEEERKGIENGYTPGLMYRRFKARFDSLFTFFQEPPYPDLLPPPPPPPYQRPLTLVLPLEDFFVHSEWTQQHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMVYSEKVVEKLDPIRAFITYNLFKDHCVYKDGIHIKDLSHLNRDLGKTLIIDTDPNSVKLQMENAILAEPWDGKADDALLRYIPFLEYLVTQPINDVRPILNSFKDRHHIPEEFAERVEKLRAKFNADQKAKAGSGLSFLLNPGMASKPAKFPLDLIREEGEKNYVRFMKLIEEEKEKLKLQQEHMSAPTFTLKDMAEGNMPTPEEQMKMQLQKQKEFEELYEKEKQKMQQQTKGQ
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.  Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM50.
What is the protein family that this protein belongs to?
Belongs to the TIM50 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: YFEO_SHISS
Sequence: MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPIWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMNQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARLY_LACLA
Sequence: MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKIAEGLKKVEEKLLNGQIEFKMENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHLYLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQHAQPISFGQHLMAYYQMLTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFLSNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRVYGNLTALLTVMKGLPLAYNKDFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKSTEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKGIYLQDVNLQDYQMLSPLINEDVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_NITEU
Sequence: MDWLILLKALLLGIVEGLTEFLPISSTGHLILAGDLLNFNDDKAKVFTVAIQLGAILAVCWEYRERLVNIIRNLGTRQANRFVINLFIAFLPAAILGLLFIKTIKHYLFHPMPVAIALVTGGILILWAERREHRIEAETVDDMSWKQALQVGCAQCLALIPGTSRSGATIIGGLLFGLSRKAAAEFSFFLAIPVMFAATFYDVYKHREFLYIDDLGMFATGSVAAFISALIAIRGFIRYISHHDFTLFAWYRIGFGLIVLLTAYSGLVDWSVD
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROQ_TRIL1
Sequence: MRILVLHGPNLNLLGKREPEIYGTLSLDDINGALEALGAEFESDLGFFQSNSEGALVDAIQQAPENYDGILINPAAYTHTSVALRDALAAIGLPFVEVHLSNIHRREEFRHHSYLAPLALGQICGFGLDSYLLGLRALFNHIKN
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: BZP1A_WHEAT
Sequence: MGSSEAETPAKANKASAPQEQQPPATSSIATPTVYPDWTSFQGYPPIPPHGFFPSPVVSNPQGHPYMWGPQPMMPPYGTPPYVIYPPGGIYAHPSMRPGAHPFAPYTMTSPNGNPDAAGTTTTAATAGGETNGKSSEGKEKSPIKRSKGSLGSLNMITGKNCVEHGKTSGASVNGTISQSGESGSESSSEGSEANSQNDSQHKESGQEQDGDVRSSQNGVSPSPSQAQLKQTLAIMQMPSSGPVPGPTTNLNIGMDYWANTASSSPALHGKVTPTAIPGAVAPTEPWMQDERELKRQKRKQSNRDSARRSRLRKQAECEELAQRAEVLKQENASLKDEVSRIRKEYDELLSKNSSLKDNVGDKQHKTDEAGLDNKLQHSGDDSQKDTN
What is the function of this protein?
Probable transcription factor that may be involved in responses to fungal pathogen infection and abiotic stresses.
What are the official names of this protein?
bZIP transcription factor 1-A, TabZIP1-A.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATG4A_HUMAN
Sequence: MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004, PubMed:32732290).  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004).  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004).  Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004).  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106).  In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989).  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989).  Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288).  Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106).
What are the official names of this protein?
Cysteine protease ATG4A, AUT-like 2 cysteine endopeptidase, Autophagy-related cysteine endopeptidase 2, Autophagin-2, Autophagy-related protein 4 homolog A, HsAPG4A, hAPG4A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.