PharMolix/UniProtQA huggingface dataset:
Protein: RECR_SACEN
Sequence: MYEGPVQDLIDELGRLPGIGPKSAQRIAFHLLAAEPADVTRLQEVLQKVKEGVVFCDICGNVSEEPTCRICRDARRDPAVVCVVEEPKDVLAVERTREFRGRYHVLGGALDPLSGVGPDQLRVRELLTRIGRDEITEVIIATDPNTEGEATATYLVRMLRDFPGLNVTRLASGLPMGGDLEFADELTLGRALSGRRAV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SYR_LARHH
Sequence: MTLTQLLHDKLAAALIAAGVPDAQPLLQPASRPEFGDFQANGVMAAAKQRKMNPRELAQQVIDKLDLAGIASKIEIAGPGFINITLAPDFLAKRLDTVLDDARLGVRSVTEPQRVMVEYSSPNLAKEMHVGHLRSTIIGDTLARVVEFLGNNMVRGNHVGDWGTQFGMLTAYLVETRQAGKADLELSDLETFYRNAKIRFDEDPVFADTARNYVVRLQGGDADVLKLWEQFVDVSLAHCEAVYRKLGVGLTRADVRGESAYNDDLPVIVDELAAKNLLSEDDGAKVVYLDEFRNHDGDPMGVIVQKKDGGFLYTTTDLGAVRYRHKELNLDRVIYVVDARQSQHFQQMFTICRKAGFAPEAMSLEHVGFGTMMGDDGKPFKTRSGGTVKLIELLDEAEERAYALVSEKNPDLPEEEKRKIAHAVGIGAVKYADLSKNRNSDYIFNWDLMLAFEGNTAPYLQYAYTRVASIFRKVDRFDASAPLLITEPAEKQLALMLAQFSDVLNEVARTCFPHLLTQYLYQVATQFMRFYEACPILKSEGATQASRLKLARITADTLKTGLGLLGIEVLESM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHM_PROM9
Sequence: MEKMLLKSTTRHVRIFTAEVVDNELQFHPNKLTLDLDPDNEFIWNEDSLNEINKKFNELIKERAGKDLDDYELRKIGSEIEGLIKILLQNGQLSYNPDCRVMNYSMGLPKTNEVL
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL20_MYXXD
Sequence: MRVKKGVKARRRRNRILKLAKGYRGRRKNCYKRANEAVERALDYASRDRMQRKRDFRRLWIVRINAAARTVGLSYSKLIAGLAKAKIGLDRKVLSDMAIADPSGFAAVANIAKAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: INAR1_SHEEP
Sequence: MLSLLGATTLMLVAGRWVLPAASGEANLKSENVEIHIIDDNFFLKWNSSSESVRNVTFSADYQILGTDNWKKLPGCQHITSSKCNFSSVELKDVFEKIELRIRAEEGNNTSTWYEVEPFVPFLKAQIGPPDVHLEAEDKAIILSISPPGTEDSIMWALDRSSFRYSVVIWKNSSSLEERTETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENVQINVDNQAYVLKWDYPYESTTFQAQWLRAFLKKIPGKHSNKWKQIPNCENVTTTHCVFPRDIFSMGIYYVRVRASNGNGTSFWSEEKEFNTEVKPIIFPPVISMKSITDDSLHVSVSASEESENMSVNQLYPLVYEVIFWENTSNAERKVLEKRTDFTFPNLKPLTVYCVKARALIENDRWNKGSSYSDTVCEKTKPGNTSKTWLIAGICTALFSILVVIYVVRVFLRCVKYVFFPSSKPPSSVDQYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETNEVAEVHEEYNSQASQDSGNYSNEDENSGSKISEEFLQQDSV
What is the function of this protein?
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa).  Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response.  Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another.  The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors.  STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).  Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
What are the official names of this protein?
Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Type I interferon receptor 1.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
Protein: FBD12_ARATH
Sequence: MEDLISQLPNELLQEILLNLPTSESVRTSVLPTRWRNLWQSVPGLYLISRQILKFVNLRTPSDVVLEMLISCSPVLQVLSICDVGVDFLKVRSQTLRSLSLWTFIFKGENDDVSLGDDGESGLVIDTPSLEFLRIRDFPLEDFRVESVISSIKMCIDGTYAYTKLQQLPEFKNLTRLYAFLHTDYSEMLPIYLSSSPNLKSIDLELHGYPKMEEIASSPVPKCLQTSIENVKIKMTPKADQEKSRKAETEVANYILENATLLKLTLWLDDEEEDESSSVLEKILTFQNYSFVEVKIGREASKFRLGYTFDEAKHFSRRFL
What are the official names of this protein?
Putative FBD-associated F-box protein At3g60710.
Protein: DPOL_HBVF4
Sequence: MPLSYPHFRKLLLLDDEAGPLEEELPRLADEGLNRRVAEDLNLQLPNVSIPWTHKVGNFTGLYSSTVPAFNPHWLTPSFPDIHLHQDLISKCEQFVGPLTKNELRRLKLIMPARFFPKLTKYFPLEKGIKPYYPEHAVNHYFKTRHYLHTLWKAGILYKRESTRSASFCGSPYSWEQELQHGSTSLNDKKGHGTESLCAQSTGILSRTSAGSSFQSKFQQSRLGLQQKQGHLANGKQGRSGRLRSRVHTPTRWPVGVEPSGTRCSNNLASRSASCFHQSAVREEANPSLSTSKRHTSTGNAVELNPVPPGLVGSEGKGSVFSCWWLQFRDAEPCSDYCLSHIINLLEDWGPCYEHGQHHIRTPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGTTRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSRIYDHQHGTMQNLHNSCSRNLYVSLLLLFQTLGRKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDLVLGAKSVQHLESLYTAVTNFLLSVGIHLNTSKTKRWGYNLHFMGYVIGSWGALPQDHIVHKIKECFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYTCITAKQAFVFSPTYKAFLCKQYMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGANIIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLRLPFQPTTGRTSLYADSPSVPSHLPVRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: PURL_METTH
Sequence: MVLTDSEMEFIRKELGRDPNPLEYGMLDVMFSEHCSYKSSRPVLGLFPTEGEDVIIGPGDDAGVVEITDELALVIGIESHNHPSAIEPYGGAGTGIGGILRDIISMGAMPVALLDSLRFGYLEDQKSRYLFEHVVRGISDYGNRVGVPTVAGEVEFDENFQLNPLVNVMCAGLVPKNDIKRGIAPRPGDVFLLMGGRTGRDGIHGVTFASEELTSSSELEDRPAVQVGDPFTKKMVMEASFEIMDEIEVSGVKDLGGGGLTCCISELVAKCDNGARVSLEAIPLREEGMTPYEIMLSESQERMIFVMAPDDVEAAMEICRKYELPAAVIGEVTDTGRMIVESEGEVIADLPAKLLADPPVVEREARKPQLPEGQVEVKHPPLKDTLLKLISSPNIASKRWVYRQYDHEVQIRTVVKPGDDAAVLRVDGTTGVALTVDCNSIHTKLDPYGGGAASVGEAIRNVVSMGAWPVCIVDCLNFGNPEKPEVFWQFRECVRGMADMAETFSTPVISGNVSFYNETEGVTVNPSPVVGVAGKLSLDSIKTLDFKDEGEEIVVIGETGPELGASEYLRTVHGIVDGKPPETDLKAEFEAAKAVKEIIDGSGNKVTAVHDCSAGGIAVAVAEMAIKSGIGARIDPMKIPGRFRNIHEALFSESNGRYIMTVRGSARDILGGLDVPWAVIGTTGGRTLEFGDVALDISELDDAYHGVIEAYMST
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEGLY_PYRFU
Sequence: MKILFLSANEFEDVELIYPYHRLKEEGHEVYIASFEKGVITGKHGYSVKVDLTFDEVNPDEFDALVLPGGRAPERVRLNEKAVEIARKMFTEGKPVATICHGPQILISAGVLKGRKGTSYIGIRDDMINAGVEWIDREVVVDGNWVSSRHPGDLYAWMREFVKLLK
What is the function of this protein?
Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals (Probable).  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively (PubMed:27530919).  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals (By similarity).  Thus, was shown to afford full protection against glycation of thioredoxin by glyoxal (PubMed:27530919).  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity).  Prevents acrylamide formation in asparagine/glyoxal and asparagine/sugar mixtures, likely by degrading asparagine/glyoxal Maillard adducts formed at high temperatures (PubMed:27530919).  Also displays proteolytic activity (PubMed:8626329, PubMed:16535492).  Cleaves at the carboxyl side of both basic and hydrophobic residues in the P1 position, indicating trypsin- and chymotrypsin-like specificities (PubMed:16535492).
What are the official names of this protein?
Deglycase PfpI, Intracellular protease I.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESR1_MACMU
Sequence: LFAPNLLLDRNQGKCVEGMVESFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGME
What is the function of this protein?
Nuclear hormone receptor.  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.  Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components.  Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.  Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.  Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP.  Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences.  Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP.  Can activate the transcriptional activity of TFF1.  Also mediates membrane-initiated estrogen signaling involving various kinase cascades.  Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: HEM1_BURMA
Sequence: MQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWMSDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPLADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPTSALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: WECF_ECO81
Sequence: MTVLIHVLGSDIPHHNRTVLRFFNDALAATSGHAREFMVAGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPKLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQVLSEKLEFDAYLTLLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIATGEVA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WASC3_MOUSE
Sequence: MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPLNVTAVTNGSHSETTSEQTQQNSTQDSGAQESEAPSENVLTVAKDPRYARYLKMVQVGVPVMAIRDKMISEGLDPELLEKPDAPVPNGESERAVEESSDSDSSFSD
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sortingg.
What are the official names of this protein?
WASH complex subunit 3, Coiled-coil domain-containing protein 53.
What is the protein family that this protein belongs to?
Belongs to the CCDC53 family.
What are the subcellular locations of this protein?
Early endosome.
Protein: DEOD_YERPA
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGICGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: DCTA_RHOPS
Sequence: MSTMTDIGASGALHRTRSKPWYKVLYVQVLIAIVLGVLLGWVSPHLATNPWIKALGDGFVKLIKMVIAPIIFCTVVSGIAHIQDARKVGRVGVKALLYFEVVSSFALILGLIVGNLVPVGHGLAAKPDAGAVAKYVDQASHMSSVDFFLNIIPESVVGAFAKGDILQVLLFAILFGFALMALGERGHRLRDVIDDTAHAVFGVIAIVMKAAPVGAFGAMAFTIGKYGPAALGNLIGLVALFYATAALFVFVVLGLIAKFVGFNIFRFVGYIKDELLIVLGTSSSESALPQLMEKLERLGCSKSVVGLVVPTGYSFNLDGTNIYMTLATLFIAQALGIELTFTEQVTILLVAMLTSKGASGVTGAGFVTLAGTLAAVNPALVPGMAIVFSIDKFMSEVRALTNITGNGVATVFVSWWEGELDHDRLQANLNRTIDPSDVETAITTG
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAIC_ECOL6
Sequence: MDIIGGQHLRQMWDDLADVYGHKTALICESSSGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESTWILQNSQACLLVTSAQFYPMYQQIQQEDASQLRHICLTDMVLPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATITECIPMMIRTLMVQPLSANDQQHRLREVMFYLNLSEQEKDAFCERFSVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRAGFCYEAEIRDDHNRPLPAGELGEICIKGVPGKTIFKEYFLNPKATAKVLEADGWLHTGDTGYRDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFCFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: MNME_HAHCH
Sequence: MYAENDTIVAIATPPGKGGVGVVRVSGPKARAIAHEVLGYDPKPRHAHYSPFFNEEGDTLDSGIALLFIAPNSFTGEDVVEFQGHGGPVVLDILVKRIVSLGARLARPGEFSERAFMNDKLDLVQAEAIADLIEATSEQAAHSAMRSLQGQFSKEIENLIESLIQLRIYVEAAIDFPEEEIDFLSDGKVLNDLDTLLSQTQSVFASAKQGALMREGMTVVIAGRPNAGKSSLLNALAGRESAIVTEIEGTTRDVLREHIHIDGMPLHIVDTAGLRDSDDVVEKIGIERAWKEIDQADRILFLVDATQTNEVSPERIWPEFYARIEHHDHITVVRNKIDLSEEAQGIDLSLSHPVIRLSAKAGNGIDVLREHLKACVGFESHAEGGFMARRRHLEALTVAEKHIQLAKQQLLSANAGELVAEDLRVAQNALSEITGAFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULS1_YEAST
Sequence: MAAVPTIDLTLADSDNEDIFHSFSSSTSVDKIDIRKENGKLRMAGLEVAQSNDDAARQAFHVFKTNISNNETFDTILSKSKTITDSTFNNEKSSNEVKQQQVLKEETMGSSNDEKKTQESSPSAEMIKLFYENDDVPLSDSFKQKEEGKRINQDEQVKENICGISSSYVSKDYDGVEDDFEPNTCQDSNLDFQEEKLNLNNKPSQQQFSDPETKDNSLKSENKDQIKGVTTTSYRDLPIESSAFQDSETQNNSKNTIPNIVNEKRTPALPSNLSSVESSLKNETAKVEGKTTVRLPGLQNNVALLEQEQSELFKHFSEQPVDISDFGRKIKRKHSGDFADNKILKRPILPSKNMDHTTHNSHDSEQKNSSIIILSDEDESGAGINDIESPLKVSEPNTADALRSSVPEVISLLDLPNIDLNNSVIKEASGSNSIPTSETDAQSSSSSVLQGTIMTEQATQSSQHECNSSLDTLKKNHQKLLKDLNSRESELRNALSCCKTNSEILRRKLSRREKEVSDAEKHWQLLLTSMARGGRTISSTQQILVDEAENQLNKLKEKRQLTKSKLDSINLKMYNYNEQWKSFVHSKNINLQKSLAALERSARDSKASATVNKRNECLAEKEKLDQMLKEGTLSFSTYKQLTGEIQQKLNDLKLGDQRTTDINSVLPIVRQPLAKRDLFIKSIDTAKDLLAKNTSRTEMTKRILYRHLDNLVSYKNFFEDGRSLIDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKSTRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIPITSEELLQQSYLFPVNADQRPPSNWNIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRALLENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALMLANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLVSYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCTINGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALRKVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNVYVPNFESLEPSTKIEQCIQVIQRVFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQKRKKEMVDSAMDPGKIKEVNSLGRRELGFLFGLNAL
What is the function of this protein?
ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4.  Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.
What are the official names of this protein?
ATP-dependent helicase ULS1, Role in silencing protein 1, Ubiquitin ligase for SUMO conjugates protein 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR7_LEPCP
Sequence: MTAALLESQLHSLPLLARGKVRDNYAVGTDRILMVASDRLSAFDVIMGEGIPGKGELLTRVALYWFDRLGHIVPNHLTGADPVSVVAPDEVDQVRGRSMLVKRLKPLPVEAVVRGYLAGSGWKEYQETRSVCGVALPSGLTNAARLPAPIFTPATKAEMGDHDINISFERMSEIIGADLAERVRAISIQLYSSAAEIALSKGIIIADTKFEFGLDEDGTLTLMDEVLTPDSSRYWPIEHYQSAYAQGRNPPSFDKQFVRDWLESVRIDGQPWNKQAPAPALPDDVIVHTAATYREALERLTA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MSRA_CORDI
Sequence: MGWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLFWETPGVVYTSVGFAGGITPNPTYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHDPTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHYAPKLAAAGLGRITTEILPLASTPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.