PharMolix/UniProtQA huggingface dataset:
Protein: BIOF_MYCBP
Sequence: MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: ATRN_MOUSE
Sequence: MVAVAAAAATEARLRGSTTATAAPAGRKGRQHRPCTATGAWRPGPRARLCLPRVLSRALPPPPLLPLLFSLLLLPLPREAEAAAVAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQCVCPTGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVPERDGNETAPEVTVTSGYALLHFFSDAAYNLTGFNITYNFDMCPNNCSGRGECKSSNSSSAVECECSENWKGESCDIPHCTDNCGFPHRGICNASDTRGCSCFPHWQGPGCSIPVPANQSFWTREEYSDLKLPRASHKAVVNGNIMWVVGGYMFNHSDYSMVLAYDLTSREWLPLNHSVNSVVVRYGHSLALHKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKDQYAVVGHSAHIVTLASGRVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILHTQGALVQGGYGHSSVYDDRTKALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPELHHDVNRFGHSAVLYNSTMYVFGGFNSLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWELATEEQAEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPVNHSCTEGQISIAKYESCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGNGWHLVGNSCLKITTAKENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGECTSSSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSSCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQASAGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCEDLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLKGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWATSFPAGTQTGEEVPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI
What is the function of this protein?
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity).  May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color.  Low-affinity receptor for agouti.  Has a critical role in normal myelination in the central nervous system (By similarity).
What are the official names of this protein?
Attractin, Protein mahogany.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: 3SE_DENAN
Sequence: TMCYSHTTTSRAILTNCGENSCYRKSRVHP
What is the function of this protein?
Inhibits acetylcholinesterase (By similarity).  Has been described to inhibit both the slowly and the rapidly inactivating phases of potassium efflux (PubMed:1304870).
What are the official names of this protein?
Dendrotoxin A, DTX-A, Fasciculin.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Acn-esterase inhibitor sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ADEC_ECOK1
Sequence: MNNSINHKFHHISRTEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYADAPALQRIDARGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYIAAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESARLAQSAPPYGNTIDRQPVSASDFALQFTPGKRYRVIEVIHNELITHSRSSVYSENGFDRDDVCFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEFTE
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: TYSY_AGRVS
Sequence: MKQYLDLLQHVMENGSDRGDRTGTGTRSVFGYQMRFDLAQGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVSIWDEWADENGDLGPVYGAQWRSWPKPGGGHIDQIANLVESIKTNPNSRRHIVSAWNPAEVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLKAGDFIHTLGDAHLYANHFEQARLQLTRQPKPLPVMRINPDVKDVFGFAFEDFSLENYSADPVIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCF1_HUMAN
Sequence: MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
What is the function of this protein?
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
What are the official names of this protein?
Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TAL_RHOCS
Sequence: MKFFVDTADLAEIRDLAATGLLDGVTTNPSLVARTGRPFVDLVAEICDVVSGPVSAEVAATDAETMLKEGRHLARIAPNVAVKVPLTPAGLKVCRTLANEGTMVNVTLCFSAAQAILAAKAGAAFVSPFVGRLDDIGQTGLNLIAEIVEIYDRYPAFTTEVLVASIRNPTHVTESARLGAHVATMPPAVIRQLFAHPLTDKGLSQFVADWQKTGQNILEQAIPDRSGQDRA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y565_STAA3
Sequence: MKLFIILGALNAMMAVGTGAFGAHGLQGKISDHYLSVWEKATTYQMYHGLALLIIGVISGTTSINVNWAGWLIFAGIIFFSGSLYILVLTQIKVLGAITPIGGVLFIIGWIMLIIATFKFAG
What are the official names of this protein?
UPF0382 membrane protein SAUSA300_0565.
What is the protein family that this protein belongs to?
Belongs to the UPF0382 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPB_BLOPB
Sequence: MSSGKIVQVIGAVVDVAFNQDVVPTVYHALEVHIDSFNKKLILEVAQQLGGGIVRCIAMGNTDGLRRGLVVINLKHSIEVPVGKETLGRVMNVLGEPIDMKGPIKEKEKWSIHRSAPLYSELSTDQDLLVTGIKVIDLMCPFSKGGKIGLFGGAGVGKTVNMMELIRNIAVEHSGYSVFVGVGERTREGNDFYNEMINSDVINKVALVYGQMNEPPGNRLRVALTGLTMAEKFRDEGHDVLLFIDNIYRYTLAGTEVSALLGRIPSAVGYQSTLSEEMGILQERITSTSLGSITSVQAVYVPADDLTDPSPATTFSHLDATIVLSRQIAALGIYPSVDPLDSNSQQLNPLIVGQEHYNVARDVKSILQRYQELKDIIAILGMDELSEEDKLIVLRSRKIQRFLSQPFFVAEVFTGFSGVYVSLRDTIQGFKEIIEGKYDHIPEQAFYMVGTIEEVIKKNKTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RAD50_METTH
Sequence: MIIRSLELKNIRSYESGRVEFDDGVTLFEGDIGSGKTTLLLAVEFALFGLGDQRGDSLLRATSNSGSVKLTFTVDGEEYTVYRELKRGSSGVQQGELYIRKQGVVKKLSAKELKAEVLEILGYREPLNPRARSRIYRYAVFTPQEQMKSIIEAPKNDRLERLRKAFDLEKYSRAADNANLVSRRIRRESESLEDRSYDLEDKKRELEGLLGEKEKLESEKKQLDSDIEGIEAEIAKLKSEMEVLQREKNRIESAEREIESLQNEIETLRSSSERLMERNRSIEEEYRRSLDELQKCSDIREKLQEELNSLGERISALELKRESLMDDSRRFREASIQYRNLVSELENLIKTGRDLEDEISGLEDYTDRIKSKIESMESIEDPGYTEDEVEAGIRKLEVEVSDLQQELGGIHGKIEDYESIGRRGVCPTCDQEVNPDYINDKLSSARERKGSVESRIADLRNEIMNKNELMKRIAEYKRSREELRLLREDLEKRIKECHRRRESLDNIRERIRQIEEGKAESEKLIEELKDAESDFNKVEHELKSLREMESGYSSKLAAASGRMDQLRTRITELNPETSREYRDNLKKIDENESNIAEKRAKIRENEEALKNRDEVESSIHDLTQSICEMENLRDEKRDRRAAVEGKIEEKQRQIGNLESEIAKKRELRKRARELGNYVTWLNEYFIPAMDDIETHVMAQINHEFNERFQKWFRVLVDDPGKSVRIDEDFTPIVEQDGYEQNLEYLSGGERTSIALAYRLALNMVVQRLTDVRSDILILDEPTDGFSKEQLYKLRDIFDELESRQIILVSHEEELENLADHIYRVEKSDGTSIIEKTG
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: IRF8_CHICK
Sequence: MCDRNGGRRLRQWLIEQIDSEQYPGLIWENEEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKIGVGNGSSLTDVGDMDCSPSAIDDLMKEPPCVDEYLGIIKRSPSPPQETCRNPPIPDWWMQQPSPSLPLVNGYTGYEQHHSGYSQMVITFFYSGRLVGHITTSYPEGCRLSLSQPSNHGEKLYTPDSLEHVRFPSAEAIQNDRQKQITKKLFGHLERGVLLHSNKQGIFIKRLCQGRVFWSGNTVVYKDRPSKLDRDEVVKIFDTNLFFRELQQYYNNQGRFPDSRVMLCFGEEFPDTVPLRCKLILVQVEQLCVRQVMEEAGKTCSSPMLPDDVQQEQVYRIFQDICGPHQRPLFRENQQIAV
What is the function of this protein?
Plays a role as a transcriptional activator or repressor.  Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)).  Plays a regulatory role in cells of the immune system (By similarity).
What are the official names of this protein?
Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, ICSBP.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction.
Protein: MDR1_LEIEN
Sequence: MSRAHAAYANEGWSAPEGGIAGKDGSTRDCSGYGSQGPLFSAEEEVKGTVVRETVGPIEIFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMSGVGSAEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHDEHSPGALTARMTGDTRVIQNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKAIDRVPPVDIDAGGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIHDTIMALPDRYDTPVGPVGSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQAALDQLIQRGGTTVVVIAHRLATIRDMDRIYYVKHDGAEGSRITESGTFDELLELDGEFAAVAKMQGVLAGDAKSGASVRDAKKASGHLGVILDEADLAQLDEDVPRTARQNVPIDELAKWEVKHAKVGFLRLMRMNKDKAWAVALGILSSVVIGSARPASSIVMGHMLRVLGEYSATKDVEALRSGTNLYAPLFIVFAVANFSGWILHGFYGYAGEHLTTKIRVLLFRQIMRQDINFFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVGFIYQWKLALVALACMPLMIGCSLTRRLMINGYTKSREGDTDDTIVTEALSNVRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYGSKLIDKGEAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVPDVDIEQAGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTVIQMLARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYAREGATDEEVEEAARLAHIHHEIIKWTDGYDTEVGYKGRALSGGQKQRIAIARGLLRRPRLLLLDEATSALDSVTEAKVQEGIEAFQAKYKVTTVSIAHRLTTIRHCDQIILLDSGCIIEQGSHEELMALGGEYKTRYDLYMSALS
What is the function of this protein?
Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells.  Confers vinblastine resistance.
What are the official names of this protein?
Multidrug resistance protein 1, P-glycoprotein 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ADDB_STRPF
Sequence: MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRTLMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGDMDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKSGLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQELFKSQKQLGASLVDKLILFLKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFHHIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLTQSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELVLSVPTVINETFDDLSPYLKELINFGLPLLDKGKNYLSYDNSDIANYKALLSQIIAINRQDLIEMSDQDKMFWTVVLRYLRKQLRKQQLELPTSDYRLSTKPLSKEVIEVCFPKGIPLKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEPFDNKLKQAIYHTNQESFFQQVYQDNAEAEYSLAILEDIVRSTAPILQLNQNIQVIDQEKNFQLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLAALKQIAPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKEHLSTGAYQTKNALYSNDELETLLNYNKYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQLKAITRFEADLDMGQARRLVTLPAKEKKECFLTLMRKESHL
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: RS3_NEIG2
Sequence: MGQKINPTGFRLAVTKDWASKWFAKSTDFSTVLKQDIDVRNYLRQKLANASVGRVIIERPAKSARITIHSARPGVVIGKKGEDIEVLKRDLQVLMGVPIHVNIEEIRRPELDAQIIADGIAQQLEKRVQFRRAMKRAMQNAMRSGAKGIKIMTSGRLNGADIARSEWYREGRVPLHTLRANVDYATSEAHTTYGVLGLKVWVYTEGNIKSSKPEHESKQRKAGRRNAAAN
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: EST2_HUMAN
Sequence: MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).  Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).  Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).  Converts monoacylglycerides to free fatty acids and glycerol.  Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
What are the official names of this protein?
Cocaine esterase, Carboxylesterase 2, CE-2, hCE-2, Methylumbelliferyl-acetate deacetylase 2.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: OPN4_MOUSE
Sequence: MDSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPTTSAHQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSLYKKWLFGETGCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGRKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSQNLEDGELKASSSPQVQRSKTPKVPGPSTCRPMKGQGARPSSLRGDQKGRLAVCTGLSECPHPHTSQFPLAFLEDDVTLRHL
What is the function of this protein?
Photoreceptor that binds cis-retinaldehydes (PubMed:19793992).  Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (PubMed:12808468).  May be involved in the optokinetic visual tracking response (PubMed:26392540).  May be involved in the regulation of retinal hyaloid vessel growth and regression (PubMed:30936473).
What are the official names of this protein?
Melanopsin, Opsin-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon.
Protein: HBB_TREHA
Sequence: MVEWTDKERSIISDIFSHMDYDDIGPKALSRCLVVYPWTQRYFSGFGNLYNAEGIMSNANVAAHGIKVLHGLDRGVKNMDNIAATYADLSTLHSEKLHVDPDNFKLLSDCITIVLAAKMGHAFTAETQGAFQKFLAVVVSALGKQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RS6_RHOJR
Sequence: MRHYELMVILDPSLDERTVAPSLDTFLNVVRQDGGKIDKVDVWGKRRLAYEILKHSEGIYAVIDISATPATVAELDRQLGLNESVLRTKVLRHNK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PVDA_PSEAE
Sequence: MTQATATAVVHDLIGVGFGPSNIALAIALQERAQAQGALEVLFLDKQGDYRWHGNTLVSQSELQISFLKDLVSLRNPTSPYSFVNYLHKHDRLVDFINLGTFYPCRMEFNDYLRWVASHFQEQSRYGEEVLRIEPMLSAGQVEALRVISRNADGEELVRTTRALVVSPGGTPRIPQVFRALKGDGRVFHHSQYLEHMAKQPCSSGKPMKIAIIGGGQSAAEAFIDLNDSYPSVQADMILRASALKPADDSPFVNEVFAPKFTDLIYSREHAERERLLREYHNTNYSVVDTDLIERIYGVFYRQKVSGIPRHAFRCMTTVERATATAQGIELALRDAGSGELSVETYDAVILATGYERQLHRQLLEPLAEYLGDHEIGRDYRLQTDERCKVAIYAQGFSQASHGLSDTLLSVLPVRAEEISGSLYQHLKPGTAARALHEHALAS
What is the function of this protein?
Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as pyoverdin.  Pyoverdin is a hydroxamate siderophore composed of a 6,7-dihydroxyquinoline-containing fluorescent chromophore joined to the N-terminus of a partly cyclic octapeptide (D-Ser-L-Arg-D-Ser-L-N(5)-OH-Orn-L-Lys-L-N(5)-OH-Orn-L-Thr-L-Thr in strain PAO1).  Specific for NADPH, which plays a role in stabilization of the C4a-hydroperoxyflavin intermediate.
What are the official names of this protein?
L-ornithine N(5)-monooxygenase, L-ornithine N(5)-hydroxylase, Ornithine hydroxylase, L-ornithine N(5)-oxygenase, Pyoverdin biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LPPG_ARATH
Sequence: MDLIPQQLKAVTLTHVRYRPGDQLGHFLAWISLVPVFISLGGFVSHFLFRRELQGIFFGIGLVISQFINEFIKTSVEQARPETCTLLEACDSHGWPSSHSQFMFFFATYFSLMGCKGIGFWFGLRSRWIMNLLHWSLAVVTMYSRVYLGYHTVAQVFAGAALGGIVGASWFWVVNSVLYPFFPVIEESVLGRWLYVKDTSHIPDVLKFEYDNARAARKDMDSAKSD
What is the function of this protein?
Exhibits phosphatidate phosphatase (PAP) activity in vitro.  May play a primary role as PAP in plastids.
What are the official names of this protein?
Lipid phosphate phosphatase gamma, AtLPPG, Phosphatidic acid phosphatase gamma, Plastidic phosphatidic acid phosphatase gamma.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: LEXA_SALNS
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVLEIVSGASRGIRLLQEEEDGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPSADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFTPIVVDLREQSFTIEGLAVGVIRNGEWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: TXF28_CTEON
Sequence: SCIKHGDFCDGDKDDCQCCRDNGFCSCSGIFGLKWNCRCDVGTT
What is the function of this protein?
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav) (By similarity).  Toxic to mice by intracerebroventricular injection.
What are the official names of this protein?
U4-ctenitoxin-Co1a, U4-CNTX-Co1a, Neurotoxin Oc M27-11, Neurotoxin Oct F28-8.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type II/III omega-agtx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PTH_ECOLI
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.  Involved in lambda inhibition of host protein synthesis.  PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EUTC_PSEF5
Sequence: MQKHPTDSQNPWLELRRLTPARIALGRTGTSLPTDAQLDFQYAHAQARDAVHLPFDHAGLSAQLAERGRDSLLLHSAATDRHSYLQRPDLGRRLSDDSAQALRDYASAHPGGFDLAVVVADGLSALAVHRHTLPFLARMEEQTAAEGWSLSPVVLVEQGRVAVADEVGQLLGAKMTVILIGERPGLSSPDSLGLYFTYQPKIGLTDAYRNCISNVRLEGLSYGMAAHRLLYLMREACRRQLSGVNLKDEAQVQTLDSDEQADMKGNFLLGPPQA
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.