PharMolix/UniProtQA huggingface dataset:
Protein: GREA_CHLPN
Sequence: MDYLEKLQVLIEEGQSANFLSLWEEYCFNDVVRGRELVEILEKVKSSSLASLFGKIVDTVVPLWEKIPEGKDKDRVLQLILDLQTSNSQMFFDIATEYVNKKYSGEENFNEALRVVGLRDGRDFQFSLSRFDFLMHMHKGNFVFHQGGWGVGEVMGVSFLQQKVLIEFEGIMSAKDISFETAFKSLTPLSGDHFLSRRFGDPDGFEAFAKENPIEVVEILLRDLGPKTAKEIKDELVDLVIPEADWNRWWQSAKTKIKKGTRIISPDNPKEPYVLSDAGCSHMGQLERKLGLSLNSAEKISLIYHFIRDLHSELKNIEIRKSLVKALQDLDVEEGNKSLILQRELLLSEYLGIKDASIDKEYITSLSEDDTSRLLENMPIVALQKSFLSLVRKYSSFWQQVFMQILLYTTSPTMRDFVYKTIKNDPSSVEVLKKRLLDSAHQPMMFPELFVWFFLKLGNHEDGLFDPEDKEVLRLFLESALNFMYQVASTPHKELGKKLHHYLVGQRYLAVRQMIEGASLPFLKELLLLSTKCPQFSSSDLNVLQSLAEVVQPTLKKHKSNVEEENVLWSTSESFSRMKAKLQSLVGKEMVDNAKEIEDARSLGDLRENSEYKFALEKRARLQEEIRVLSEEINRARILTKDLVFTDKVGVGCKVTLKGDAGEVVEYTILGPWDADPDSCILSLQSKLAQNMLGKKLNDVVILQGKEYKISRIQSIWEEHGA
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides (By similarity).
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RS14_LIGS1
Sequence: MAKKSKIAKYRKQQMLVAKYAEIRKQLKVNHDYESLRKLPKDSNPIRLKNRDEIDGRPRAYMRKFKMSRINFRELAHQGKIPGVHKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: METK_LEGPL
Sequence: MNEVYVFTSESVSEGHPDKIADQISDAILDAILAQDPKARVACEVLVKTGMVLVGGEITTKAWVDVEDITRHVIKDIGYNSSQMGFDWESCAVLSAIGKQSPDIAQGVDNQQTKILGAGDQGLMFGYASRETDVFMPAPIAYAHRLMEKLAKARKSGQLPWLRPDAKCQLTLKYEQGMPVEVDTVVFSTQHSPDIEHKDLVEAIREEIIKSVLPAEWLNDKTRYFINPTGRFVIGGPLGDCGLTGRKIIVDTYGGMARHGGGCFSGKDPSKVDRSAAYAARHVAKNIVAAGLADKCELQISYAIGVAEPTSIFVDTFGTGRLKNSEIIDLIHTHFDLTPQGIIDQHDLLRPIYRQTATYGHYGRESFPWERLDKVAELSKAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK1_RANDY
Sequence: MDEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHARRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIASKKPLFHGDSEIDQLFRISELWGTPNNEVWPEVESLQDYKNTFPKWKGGSLAANVKNIDKEGLDLLAKMLVYDPAKRISARKALLHPYFDDLDKSSLPANQIRN
What is the function of this protein?
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins.  Required in higher cells for entry into S-phase and mitosis.  May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
What are the official names of this protein?
Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: HAT2_CANAL
Sequence: MSEQPTEPLSIKEEYQLWRKNCRYMYEFVSETALMWPSLTIQWLPNYTTTNGLIDAKLLLGTHTSNQSANQLKVASTQLSADPNVKANSKIKTVQKLENNAEICRARYMPQDANIVATINGLGEVDLYNLDTETRYSHFAPHTKNGYGLSWNPKQKGLLVTGADDNFVCVTDTTTNKTTFKSDIQKDIVNDVKWHQFNGNLFASVSEDSHVYLFDARDNKVVSQYYAESSNGINSLAFSPFAENLVAIGNTSSNINLLDLRKLGENSGLLHTMMGHSEGITCMEFSPHHDGILATGSQDRRIIIWDLFKVGEEQQQEDAEDGCPELFMMHAGHTAGVSDLSWCPFKDWMIGSVADDNIVHLWEISKKLITNEEAEVDVSILE
What is the function of this protein?
Regulatory subunit of the histone acetylase B (HAT-B) complex.  The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing.
What are the official names of this protein?
Histone acetyltransferase type B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NEMP_DROME
Sequence: MHSAGLLMLTVAGYFTSGIPGNTASSDVAYLTPGTYINLSENILGLQTLRTFCYPGKRLTVSSLFETVEFVLAIGSDDYSQYGGKTPEEVLQHYKDKQSLFSITLFAQKRQLLQLSPFEQQCIGISSRQAYTVILNSIPLDLWRLAQFAVGILILFSARRLAKNSVFYYLVGIVIGICASLLVVIYLAAKLFPRRTMMYGVLIGGWTIGFYVIKQLADNLRLILITYRDHVLGYLVITGLISFLICYRIGPPKNPRSQTIVMWVLQAIGAVMAYFSSWHTSAVIFIMVLVFVAHYFPISWTNQIKFMYRRRFPLKRRMLTQEEYEQQTAVETSKSLADLRKYVNSPECKQWAVMGKLRDPLRFASFANGAPHLDDEEIEDHSRTIEESMDAAPEEESVEEPEEDKPAELLPLPNSQFRYQQAARNSEPEPESESDDSEEEEFFEQEVDLRQVVQ
What is the function of this protein?
Contributes to nuclear envelope stiffness in germ cells (PubMed:32923640).  Required for male and female fertility (PubMed:32923640).
What are the official names of this protein?
Nuclear envelope integral membrane protein.
What is the protein family that this protein belongs to?
Belongs to the NEMP family.
Protein: EUPB_PHOSX
Sequence: MTIYTFTSSEPHIAIVGGGIVGVILTLGLLRQNVSVRLYEQSAGFREIGAGIAFTASARRCMELMDPAIIDALRRCGAVSVSDKVADEDDHLRWIDGYNQHSKAHPTYQKPLAEICGSGFQGCRRDQLLEELAKHIPSGTIMFHKRLDTIQQGKDHKMILNFVDGSSNQADAVIGCDGIKSRVRQHLFGDNHPASFPQYTHKVAYRGLVPMDRAIEILGTWKAHNFHHHVGPGAHLTHYPVANHTALNVVVFLSDETPWPDSTTMVSKGTRSEVEKALQGWHPTVLGIVNLLPDELSKWALFDQGEFPLPHYSKGRICLAGDAAHASSPHHGAGACLGVEDALCLSTLLSQVRTTLTQADEGSKDKSESSMGQLLEAAFETFNLVRRTRTQWLVNSSRRVCDLYHQQEWADPIRCPKAETCFEEIRDRSYKIWHFDVDGMLEQTRT
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of eupenifeldin, a bistropolone meroterpenoid that acts as an antitumor agent (PubMed:30980906).  The first step of eupenifeldin biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase eupA (PubMed:30980906).  Oxidative dearomatization of 3-methylorcinaldehyde likely catalyzed by the FAD-dependent monooxygenase eupB is followed by oxidative ring expansion by the 2-oxoglutarate-dependent dioxygenase eupC to provide the first tropolone metabolite, tropolone stipitaldehyde (Probable).  In parallel, generation of sesquiterpene alpha-humulene from farnesylpyrophosphate (FPP) is catalyzed by the terpene cyclase eupE (PubMed:30980906).  The cytochrome P450 monooxygenase eupD then hydroxylates humulene to humulenol (PubMed:30980906).  The putative Diels-Alderase eupF probably catalyzes the formation of the tropolone-humulene skeleton by linking humulenol and the polyketide moiety (Probable).  The short-chain dehydrogenase/reductase eupG and the flavin-dependent monooxygenase eupH are also essential for eupenifeldin biosynthesis and are likely the additional decorating enzymes of the tropolone-humulene skeleton to produce final eupenifeldin or derivatives (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase eupB, Eupenifeldin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NDUB2_PONPY
Sequence: MSALIRLASFARVGGRLFRSGRARTAGDGGVRHASGGVHLEPRYRQFPQLTRSQVFQSEFFSGLMWFWILWRFWHDSEEVLGHFPYPDPSKWTDEELGIPPDDED
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial, Complex I-AGGG, CI-AGGG, NADH-ubiquinone oxidoreductase AGGG subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB2 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RF1_BACLD
Sequence: MLDRLKSIEDRYEKLNELLSDPEVVNDPKKLREYSKEQSDLQETVEVYRRYRSASEQLSDAKAMLEEKLDSDMREMVKEEISELQEEIESLTDQLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANMTGTGGYKEIIFMINGNGAYSRLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQNRKSAVGTGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGKLDEVIDALIVEDQASKLQQAES
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP422_SCHJA
Sequence: MHECMIVFFIFAVVSIYYADAESCLYLGQHCNALATKKCCPPFTCKFVNQREGICVREDPGAESCLYLGQHCNALATKKCCPPFTCKFVNQREGICVREDPGVGGGCLPDKQQCRRNKDCCSKSCYRGNCRSK
What are the official names of this protein?
Egg protein CP422, Protease inhibitor bi-domain.
What are the subcellular locations of this protein?
Secreted.
Protein: DHA_BACSU
Sequence: MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSGFENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPELAQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAGVPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLISNPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETVDHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALADNTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA
What is the function of this protein?
Catalyzes the reversible oxidative deamination of L-alanine to pyruvate.  Oxidative deamination proceeds through a sequential, ordered ternary-binary mechanism, where NAD(+) binds first followed by L-alanine; the products are released in the order ammonia, pyruvate and NADH (PubMed:6794611, PubMed:6794612) (Probable).  Disruption blocks sporulation probably in stage V; 20-30% sporulation can be restored if the media is supplemented with pyruvate, suggesting lack of pyruvate blocks sporulation.  Thus it is a key factor in the assimilation of L-alanine as an energy source via the tricarboxylic acid cycle during sporulation (PubMed:8226620).
What are the official names of this protein?
Alanine dehydrogenase, Stage V sporulation protein N.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_LIMRJ
Sequence: MNFLSAVLTILSSFLITFLLMPSLIKYFRAKKEGQQIRKEGPTWHAKKAGTPTMGGLLFIFSAVVTILWVAAWQGLITNTLWALLFVLVVYGLIGMWDDSIKIFHHQNEGFKPWQKALCQVLAAMVFTVIYQHEGFQMGFGTTQIGWLYGLFIIFWIVGFSNAVNLTDGLDGLVSGLSIISFAAYLIIALVNLNQPGYPEIALFCLAMIGTLLGFFPYNHKPAKIFMGDMGSLAIGASLAAVSLLLHHEWSLLVIGIVYVCETASVILQVASFKTTGKRIFKMTPIHHHFEMSGWSEWKIDIVFWLVGLVAAIIAVTTILLVG
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYH_DEIRA
Sequence: MAIQRPKGTNDLLPSGSPKTEAFQRAAAHEWLIAQAREVLERAGAQRIDTPMFEEAELVKRGVGGSTDIVRKEMFTVYYFGDHGGYVLRPEGTASIVRAYLENGLKQLPAPLKLWTSGPMFRAERHQKGRYRQFTQVDYEVLGSADALVDAEAIALMVAVVQKLGLRGVRVKLGSIGDPEDRERYNAYLRDLFSPHLGRLSDDSKDRLERNPMRILDSKSASDQELLAELSVRPMLDFLGEGAAADFRQVQAYLSDWGVPFDLDPSIVRGLDYYRRTAWELHYEGIGAKSALGGGGRYDGLSEQLGGGSVPGIGWAFGVERLLLALEQEGIEIPGSGGPQLYVAALDEENVPLAARVALAARASCRAEFAYRAMKPGSAFKDAERRGAVWVGLIGSEEAAAGTLSLKNLHTGEQKTVPVGELGQALA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO1_MIMIV
Sequence: MEANKNTYSRLGDTIETVERIEFCINSNESIIRHSAIVDPNGITEAETFNSNNNEPVQGGVIDKRLGVTESHLECSTCGETALRCPGHFGHIKFVEPVFHMGYLIYLKHILSCICIRCNKLLVYKNEKEIAALIKNKQGKQRFAEIRSICKKVTHCQKENYGCGTPAHKISIDKRNGNIFLLAEPVKRTDEYDETGETRKRPQQILTPQLCYDILKSVSDEDCIIMGFDPAKSRPEDMIILNFPVPPVQVRPSIRAEILSSPTMDDDLTHKLIDIIKSNENLKNTKGDGSLIKYTSINDDFMLLQLHVATFFANDMAGLARSQQKNKKVTKSMSERLRGKEGRIRGNLMGKRVDMSARTVITSDPNIALNEVGVPLIIAKNLTFDEIVTEHNIEYLTQLVKNGKRVYPGANFVIKHVIDAEGNESGHIYHLKYVDKPISLKPGDIVKRQLIDGDIVIFNRQPSLHKLSMMGHKCHVIPDNNLLTFRVNVSVTDPYNADFDGDEMNLHVPQSIQTATEILLIANASRRFVSPATSNIAIKAKQDTLMGSYVQTEPDMEIDWRDAMSILMSTSVKLDNDIPKYQNVSGKFLYSQIIPEGLNITKRKNDKEFQLKIKNGELTDGTLGKSEISSILQRIWFQYGSKETQEFIDDAQRMILQFLMRYGYTVSIKDTVIGEKVNQYIYDLIETKRKETLAFITEYDNDPYVMTKDAFEIKLQENLKSVQDEIKNTVMRNFDKNSGIFIAISSGSSGEPMNAGQIAGCIGQVIVEGKRIQIRFNGRTLPMFPKFDDSAFSRGFCRNSFIEGLGPFEFFFQVMAGREGIINTAIKTADTGYIQRKLVKMLEDIKQEYDGTVRNANGKLISCVYGDNGINTENQVDQKIDLISANDNKVRNDYVYTEDEIKYLIKNHKTDKRYTTDLNNSLYRKLISMRDQLRRIQRLVNLTSAEFKETYKMPVDIQQFIFNIINRDVRNNNVVVDPYYVLKMIKDMYYGSDSKIMKYNNRTSRIKKEDEKRIKFLMKIYLYDVLAPKKCTHVYKFSKQEFDEIVDYFKKTIMLAKVEGGEMVGFVAAQSIGEPVTQTNLKSFHKSGTGKTVSGGLVRVKELLGISKNIKTPITEIILEEKYKNDKITASRIASYLKYTTLRDVVEKADVIYDPEPFSKDGLMKKDGVDNIFDQEQGKTGCQTDIKNLPWVLRIMLSKEKMIERNINMLEIKTSFCRNWGTRNEDKTSKKEFNKVIDKITQCAIVTNYDNSQVPIVHVRFDANNYNLNTLIQFQEMVINTYKIKGISNITESNNIIEESYVDFDDEGNVVKKKQYVIIAEGINLSEMSQINGIDLLRTKCNDIVTIYEMYGVEAARTAFIKEFTAAIESSGGFSNYQHIEILADAITHMGGLIPVNRHGANKLDTDPFSRASFEKTVEQLLAAAVFGESDHMRSVSARIMVGALINGGTGCFDLLLDHKKIQQSLVESEEVVAPVVPIKKKTVLDDLISKKKSK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Virion.
Protein: CSAG2_HUMAN
Sequence: MWMGLIQLVEGVKRKDQGFLEKEFYHKTNIKMRCEFLACWPAFTVLGEAWRDQVDWSRLLRDAGLVKMSRKPRASSPLSNNHPPTPKRRGSGRHPLNPGPEALSKFPRQPGREKGPIKEVPGTKGSP
What is the function of this protein?
Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype.  May also be linked to the malignant phenotype.
What are the official names of this protein?
Chondrosarcoma-associated gene 2/3 protein, Cancer/testis antigen 24.2, CT24.2, Taxol-resistant-associated gene 3 protein, TRAG-3.
Protein: ACDA_ASPCN
Sequence: MADRSDIIIENYQVSPRIGFLPDKPPLARLPHPYYAGWEETISRVAPSRGDGRAREYIDEMPLLSTGKLRVLPEWHRAYTLLSILSQVYIWDGDEPSNRIPASIASPLLAVSEHLGLNPCASFASFCLWNIRPVGRHGLNYAAAYEPENLGQITSFTGTTDEEWFFSISAAIEARGGCLIPGMFDTIEAAREGNSQRVQEFLGTLASCVRHMCKDLKRMYEGCAPSVFYHDVRPFLNGGKGVNKDTQTPGGVFYENESGGGQWHQYQGGSNAQSSLIQLLDIFLGVDHSITAANKPHEGYHREMQSYMPGKHRQFLQLMSRLSNVREFVLCHPVTAEIRIEYSRATAELVALRQTHMIMASRYIVMQGRKGSMCRDSSKGTGGTEFMPFLKDARDCTLATCCPRP
What is the function of this protein?
Indoleamine 2,3-dioxygenase; part of the gene cluster that mediates the biosynthesis of aspcandine, a pyrrolobenzazepine alkaloid (PubMed:35748771).  Initially, the indoleamine 2,3-dioxygenase acdA accepts L-tryptophan and performs the oxidative opening of the indole ring to yield N'-formyl-L-kynurenine, which undergoes the spontaneous deformylation reaction to provide L-kynurenine (PubMed:35748771).  The kynurenine 3-monooxygenase acdD then hydroxylates L-kynurenine to afford 3-hydroxy-L-kynurenine (PubMed:35748771).  3-hydroxy-L-kynurenine is activated by the A domain of the NRPS-PKS acdB and subsequently loaded onto the enzyme (PubMed:35748771).  The KS domain conducts the decarboxylative condensation of the 3-hydroxy-L-kynurenyl and malonyl moieties, and subsequent nucleophilic attacks by the two amino groups would occur nonenzymatically at two distinct positions, achieving the chain release and the construction of the tricyclic system (PubMed:35748771).  Finally, a dehydration reaction completes the biosynthesis to yield aspcandine (PubMed:35748771).
What are the official names of this protein?
Indoleamine 2,3-dioxygenase acdA, IDO acdA, Aspcandine biosynthesis gene cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
Protein: ARGB_SHELP
Sequence: MSANKKTLVLKVGGALMQCEMGLARLMASAANIIKSGQSVILVHGGGCLVDEQLKANGMETVKLDGLRVTPEEQVPIVVGALAGTSNKILQASAIKAGITSVGMSLCDGAIVNGSIKDEQLGFVGEVSPNDPTYLNFLLAQGWMPIVSSIAVDDAGNLLNVNADQAATVIAKLVEGQLVLLSDVSGVLDGKGQLIKTLDKAHADELTKLGVIEKGMKVKVEAALEVAQWMGQPVQVASWRDAEQLSALEKGESIGTQVMPH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO1A1_CANLF
Sequence: MFSFVDLRLLLLLAATALLTHGQEEGQEEDIPPVTCVQNGLRYYDRDVWKPEACRICVCDNGNVLCDDVICDETKNCPGAQVPPGECCPVCPDGEASPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQMSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGARGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPSGPPGPKGNSGEPGAPGNKGDTGAKGEPGPTGIQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGEAGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPTGPPGPIGNVGAPGPKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGARGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGTSGERGPPGPMGPPGLAGPPGESGREGSPGAEGSPGRDGSPGPKGDRGETGPAGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPIGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSGGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPQVAQKNWYISKNPKEKRHVWYGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTYDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGMDIGPVCFL
What is the function of this protein?
Type I collagen is a member of group I collagen (fibrillar forming collagen).
What are the official names of this protein?
Collagen alpha-1(I) chain, Alpha-1 type I collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HSP7E_MACFA
Sequence: MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRSSNDPQAQKYITESKCLVIEKNGKLRYEIDTGEETRFVNPEDVVRLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPNGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVKGNARAMMKLMNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQSGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEVAS
What is the function of this protein?
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.  In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).
What are the official names of this protein?
Heat shock 70 kDa protein 14.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PDXH_VIBC1
Sequence: MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQRIVLLKSVDKDGFVFYTNLGSRKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENMKYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKFAKGEIPMPTFWGGFRVKPQSIEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: WZYE_SHIDS
Sequence: MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWMILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNRETNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GEP3_CANDC
Sequence: MFSRLVLLRKVSISLGRYYSSQAHPQTYIYNLLSKSKCRSCGIQLQDKYPDKPGFYRLPGQNDNNTDNKSKTSELNKKYEKILQNLDVSDRNLLINNFSAPKQEHEKITSVPSLQQVTPVEEDACDTLEVQKTQQGQSLSCKRCNDVIYNSKNKSVYDPKRDNLNKSEFPIPKLQQVLSTIPIDAPLVYVFSANDFPMGINQEIFQYRPPQQIFFVMTKSDILIPKTNVAFYNNFKKFLQNYMFKRFNVPRENVFIASGKDRWKMNDLYHFIPNYAYIIGDTNCGKSTLVKSLLINHHVKHWKYEARQQRQNERPNGKQSSSASLKNKDFKQLDRLIDSFSSKNGPGTSHIPGFTRDVVPVDIDGIKQLFDVPGFTTNENMQDIFDKLNHKQIARITKGTSTFKYGSLKSKFDTIKNGQVLSLNGVGYLQFPGQDSMYQIRNVTRFALHKFKNLEKVDSILQRNEIPTSMSSHFIVNRQQQQQQRNEIRGYYKRYIVPPFYGTIDLVIKDIGYINIKPTGKKLTNELMVLYLHPSLEAIIRQPILNYIDPPSPKKLIDGTKMKSFITSDIGKTPFYSRLIPSKIPSDPSSFLASSPSSDYNQLNQYLQIDESSESAYNDILELDETNKYDYWIE
What is the function of this protein?
May be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.