PharMolix/UniProtQA huggingface dataset:
Protein: KCNH8_RAT
Sequence: MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVVTSTADVKDSKAINV
What is the function of this protein?
Pore-forming (alpha) subunit of voltage-gated potassium channel.  Elicits a slowly activating, outward rectifying current.  Channel properties may be modulated by cAMP and subunit assembly.
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 8, Ether-a-go-go-like potassium channel 3, ELK channel 3, Voltage-gated potassium channel subunit Kv12.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PTH_SHELP
Sequence: MSNIKLIVGLANPGDKYEQTRHNAGAWYVNELARVCGVSLVADSKYYGLTARATLYGKDVRLLIPTTFMNLSGKSVGALANFFRIAPDEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSMVSNYVLGKAPQTEQRLIEEVIDEAVRATEVLFKEDMSKAMHRLHSYKAG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL2_CERSK
Sequence: MDQSNRYARLDLKEADLIAGGRHVLCAYVMKPKAGYGYLETAAHFAAESSTGTNVEVSTTDDFTRGVDALVYEIDPEKEIMKIAYPVELFDRNIIDGRAMLCSFLTLTIGNNQGMGDVEYAKMHDFYVPPCYLRLFDGPSMNIADMWRVLGRDVRNGGMVVGTIIKPKLGLRPKPFADACHEFWLGGDFIKNDEPQGNQTFAPLKETIRLVADAMKRAQDETGEAKLFSANITADDHYEMVARGEYILETFGENADHVAFLVDGYVTGPAAITTARRQFPRQFLHYHRAGHGAVTSPQSMRGYTAFVLSKMARLQGASGIHTGTMGYGKMEGEAADKIMAYMLTDEAAEGPFYRQDWLGLKATTPIISGGMNALRLPGFFDNLGHSNVIQTSGGGAFGHLDGGTAGAKSLRQSHEAWMAGVDLVTYAREHRELARAFESFPADADKFYPGWRDRLQRAA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type II subfamily.
Protein: RS18_SHEFN
Sequence: MARYFRRRKFCRFTSEGVVEIDYKDIVTLKNYITESGKIVPSRITGTSARYQRQLARAIKRARYLSLLPYTDLHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: HIS5_ZYMMO
Sequence: MKNQASSTVALIDYGAGNLRSVANALLASGLARENLVVTANPDEVLQADRVVLPGVGAFASCMQALKAIPDMVPALEKAVLEKGRPFLGICVGMQLLADQGEEYGVHQGLGWIKGKVTPLRPNDPSCKVPHMGWNQIGLTTDSHPLLRAGEAYFLHSYAFVPEDESTLLATTEHGGLVTAAVGRDNIMGVQFHPEKSQSYGLEFLSRFLDWNP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT3_CAEEL
Sequence: MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEAMFQPSFLGMESAGIHETSYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-3.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NANE_LISMF
Sequence: MGNSVMEKIKGGLVVSCQALEDEPLHSAFIMSKMALAAVQGGAVGIRANTAKDIRAIQSEIDVPIIGIYKKDYDDSDVFITPTLEEVREICETGVEIVAMDATTRKRPHNEDLKDILNAIRKEFPNTLFMADTGSIEDVYYADSLGFDLIGTTLYGYTEETANKNISDDDFSHLKEVLKSTKRPVIAEGKIDSPSKARQVLTLGCYAVVVGGAVTRPQEITTRFTNEIKKI
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: CSCLD_ARATH
Sequence: MEFGSFLVSLGTSFVIFVILMLLFTWLSRKSGNAPIYYPNRILKGLEPWEGTSLTRNPFAWMREALTSSEQDVVNLSGVDTAVHFVFLSTVLGIFACSSLLLLPTLLPLAATDNNIKNTKNATDTTSKGTFSQLDNLSMANITKKSSRLWAFLGAVYWISLVTYFFLWKAYKHVSSLRAQALMSADVKPEQFAILVRDMPAPPDGQTQKEFIDSYFREIYPETFYRSLVATENSKVNKIWEKLEGYKKKLARAEAILAATNNRPTNKTGFCGLVGKQVDSIEYYTELINESVAKLETEQKAVLAEKQQTAAVVFFTTRVAAASAAQSLHCQMVDKWTVTEAPEPRQLLWQNLNIKLFSRIIRQYFIYFFVAVTILFYMIPIAFVSAITTLKNLQRIIPFIKPVVEITAIRTVLESFLPQIALIVFLAMLPKLLLFLSKAEGIPSQSHAIRAASGKYFYFSVFNVFIGVTLAGTLFNTVKDIAKNPKLDMIINLLATSLPKSATFFLTYVALKFFIGYGLELSRIIPLIIFHLKKKYLCKTEAEVKEAWYPGDLSYATRVPGDMLILTITFCYSVIAPLILIFGITYFGLGWLVLRNQALKVYVPSYESYGRMWPHIHQRILAALFLFQVVMFGYLGAKTFFYTALVIPLIITSLIFGYVCRQKFYGGFEHTALEVACRELKQSPDLEEIFRAYIPHSLSSHKPEEHEFKGAMSRYQDFNAIAGV
What is the function of this protein?
Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions (PubMed:30190597).  Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (PubMed:30190597).
What are the official names of this protein?
CSC1-like protein ERD4, Hyperosmolality-gated Ca2+ permeable channel 3.1, AtOSCA3.1, Protein EARLY-RESPONSIVE TO DEHYDRATION STRESS 4.
What is the protein family that this protein belongs to?
Belongs to the CSC1 (TC 1.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL30_NITMS
Sequence: MANAVLVVRIKGQADCPYWASTTMDLLKLERKYRAVILPAKDNLLGMLKKVQHYVAWVDLDTELAQELIDKKARKSGYKKVTPEDLKELGYASSAELAAALTEGKTMLSKLKPLKPWFALAPPRHGFKRSTKRLYGQKGILGRNKELATIVRNMI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: EIF3C_DICDI
Sequence: MSRFYRQGSSSESSSESSSDSDVQVKKPTRYVSSSEDEIEEKRIVLSAKDKIWQQFDESLKKVRNALKTNDWVSTTSEFDNMTKLITNGKTTRIIEKEGFPPSFIKALFIIQTSHRDLTTEQKKKLHANNNKSYNSIKQKLKKTCDLYAKELKPYHDNPALVNEQENKANSDDDDDDLSESESEESESSDDDKGKGKGKAAFGKKPATKAVVAKKPLTKKGDDDSESESEESESESEELISESWSSDSDDDSDSDSDDDSGDNKWMIKDDKKVVAKASVTTVRKTDKDKLDRRNAVVSPLSGSGSAVPTAGEGEGEKLTQDQIMKKVKEVISNRGKLKTDPMKQIQQLEYFYSLIQGDKETFIVLYELIAAQFDTASVKVALSIPVWQKVADGIKKLLEILETNTNFVLVLEHQEPTISKGQVAVTGNLLALFEMLDDEFSKSLQSINYPTKEYLDRLQDEQIILDLGESLQKYYESAGNNGAAAKIAIRRIEHIYYKSSNLKNNIIPSTMPLSEQITLMSKLSSFVYKFGDERLNARTILCNIYFNAINNKFHEARDMMLMSHLQDNPTLMDVSTQILFNRAMVQLGLCAFRCGYIQEAQNCVVEFSGLRKDLLAQGLSVQSKTAEKDTVREVEETTRILPAHMWIPIDLIETVNLISGMLIAVPQNAYRPFDNKFKTCKFYQRHMDSVDRQIFIAPSETSKDIIYQASKALSAGDWQQCLEHVNTLRFWSLIPDIDSVREKLTRIVQEVSLKTFLFTYSTSYDSILLSELADRFHLPKSQVHSIVAKMMNNHEISASMEHSTESITFRAEQTKLQYLALHYSESLVDFVEQNERIYDVKFGTSYRKKGDNDHLPIAGGQHHGHQHHGHQHHGHHHHNQQQQQHHQQQQQTTQHHHHHHQNQNQGNQQYQNKKHHNSNQQKSHKKRQNNSLVVNN
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CORIN_MOUSE
Sequence: MGRVSFSVRVSSVRRARCSCPGRCYLSCRVPPTTALRALNGLGCAGVPGETAGGAVGPGPLGTRGFLSGSKFQAPGSWKDCFGAPPAPDVLRADRSVGEGCPQKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKRVYFKSNDSEPLVTDGEARVPGVIPVNTVYYENTGAPSLPPSQSTPAWTPRAPSPEDQSHRNTSTCMNITHSQCQILPYHSTLAPLLPIVKNMDMEKFLKFFTYLHRLSCYQHILLFGCSLAFPECVVDGDDRHGLLPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRDHTETNSSVRKSCFSLQQEHGKQSLCGGGESFLCTSGLCVPKKLQCNGYNDCDDWSDEAHCNCSKDLFHCGTGKCLHYSLLCDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCHSQGLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDSQTPCPEGEQGCLGSSCVESCAGSSLCDSDSSLSNCSQCEPITLELCMNLPYNHTHYPNYLGHRTQKEASISWESSLFPALVQTNCYKYLMFFACTILVPKCDVNTGQRIPPCRLLCEHSKERCESVLGIVGLQWPEDTDCNQFPEESSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERALWECPFNKQCLKHTLICDGFPDCPDSMDEKNCSFCQDNELECANHECVPRDLWCDGWVDCSDSSDEWGCVTLSKNGNSSSLLTVHKSAKEHHVCADGWRETLSQLACKQMGLGEPSVTKLIPGQEGQQWLRLYPNWENLNGSTLQELLVYRHSCPSRSEISLLCSKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPSPEEYLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVGWIERQIYIQTFLQKKSQG
What is the function of this protein?
Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing (PubMed:11884416, PubMed:15637153).  Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (PubMed:11884416, PubMed:15637153, PubMed:22418978).  Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503).  Also acts as a regulator of sodium reabsorption in kidney (PubMed:20613715, PubMed:22418978).  May also process pro-NPPB the B-type natriuretic peptide (By similarity).
What are the official names of this protein?
Atrial natriuretic peptide-converting enzyme, Corin, Low density lipoprotein receptor-related protein 4, Pro-ANP-converting enzyme.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.
Protein: KHPB_BACSU
Sequence: MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGIFGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALLIGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKTKKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR
What is the function of this protein?
A probable RNA chaperone.  Forms a complex with KhpA which binds to cellular RNA and controls its expression.  Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
What are the official names of this protein?
RNA-binding protein KhpB, RNA-binding protein EloR.
What is the protein family that this protein belongs to?
Belongs to the KhpB RNA-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBH_CUCSA
Sequence: MATQTVDDSSKSGPRRTVVGDLLKPLNSEYGKVAPGWGTTPLMGVAMSLFAIFLCIILEIYNSSILLDGISSN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NU4M_FELCA
Sequence: MLKIIIPTAMLMPMTCLSKPNMIWINSTTYSLLISLISLSYLNQLGGHSLNFSLLFFSDSLSAPLLVLTTWLLPLMLMASQSHLSKETPSRKKLYITMLTLLQLLLIMTFTATELIMFYILFEATLIPTLIIITRWGDQTERLNAGLYFLFYTLVGSLPLLVALLYIQNTTGTLNFLIIQYWAKPISTTWSNIFLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITVLLNPATNQMAYPFMMLSLWGMVMTSSICLRQTDLKSLIAYSSVSHMALVIVAVLIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERVHSRTMILARGLQTILPLMAAWWLLASLANLALPPTINLIGELFVVMASFSWSNMTIILMGTNIIITALYSLYMLIMTQRGKYTHHIKNINPSFTRENALMALHLLPLLLLSLNPKIVLGPIY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL30_NEIM0
Sequence: MAEQKKIRVTLVKSLIGTIESHRACARGLGLRRREHTVEVLDTPENRGMINKISYLLKVES
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: FPG_RHILO
Sequence: MPELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYLTMHVQDGPVLICHLGMSGSFRIETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSRVIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGVLLASLLKGRGSPLKAALLDQKLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGSSLRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SBT17_ARATH
Sequence: MSSSFLSSTAFFLLLCLGFCHVSSSSSDQGTYIVHMAKSQMPSSFDLHSNWYDSSLRSISDSAELLYTYENAIHGFSTRLTQEEADSLMTQPGVISVLPEHRYELHTTRTPLFLGLDEHTADLFPEAGSYSDVVVGVLDTGVWPESKSYSDEGFGPIPSSWKGGCEAGTNFTASLCNRKLIGARFFARGYESTMGPIDESKESRSPRDDDGHGTHTSSTAAGSVVEGASLLGYASGTARGMAPRARVAVYKVCWLGGCFSSDILAAIDKAIADNVNVLSMSLGGGMSDYYRDGVAIGAFAAMERGILVSCSAGNAGPSSSSLSNVAPWITTVGAGTLDRDFPALAILGNGKNFTGVSLFKGEALPDKLLPFIYAGNASNATNGNLCMTGTLIPEKVKGKIVMCDRGINARVQKGDVVKAAGGVGMILANTAANGEELVADAHLLPATTVGEKAGDIIRHYVTTDPNPTASISILGTVVGVKPSPVVAAFSSRGPNSITPNILKPDLIAPGVNILAAWTGAAGPTGLASDSRRVEFNIISGTSMSCPHVSGLAALLKSVHPEWSPAAIRSALMTTAYKTYKDGKPLLDIATGKPSTPFDHGAGHVSPTTATNPGLIYDLTTEDYLGFLCALNYTSPQIRSVSRRNYTCDPSKSYSVADLNYPSFAVNVDGVGAYKYTRTVTSVGGAGTYSVKVTSETTGVKISVEPAVLNFKEANEKKSYTVTFTVDSSKPSGSNSFGSIEWSDGKHVVGSPVAISWT
What is the function of this protein?
Serine protease.  Has a substrate preference for the hydrophobic residues Phe and Ala and the basic residue Asp in the P1 position, and for Asp, Leu or Ala in the P1' position (PubMed:12413398).  Essential for mucilage release from seed coats.  Triggers the accumulation and/or activation of cell wall modifying enzymes necessary either for the loosening of the outer primary cell wall, or to facilitate swelling of the mucilage (PubMed:18266922).
What are the official names of this protein?
Subtilisin-like protease SBT1.7, Cucumisin-like serine protease, Subtilase subfamily 1 member 7, AtSBT1.7, Subtilisin-like serine protease 1, At-SLP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Intracellular spaces and cell wall.
Protein: ARLY_SORC5
Sequence: MSVRLWDKGGATDAQMLRYTSRDDWQLDQRLLAYDLRATIAHVRGLARIGVLSEAERDALVRELEVLSAQNEAGELRLTEDDEDGHSAIEAALVARIGDAGKKVHTGRSRNDQVLVATRLYERDALDELAENAAAGARALLDLARREAETPMPGYTHLQRAVPSSVGYWAASFVEGLADAIDVVRATRALVDRCPLGGAAGFGVNLPLDRVGVARELGFAGVALNPLASQTSRGIIEAQILAAAWQVMAVSRRLAWDLSLFAMSELAFIRLPEAFTTGSSIMPQKRNPDVVELMRAACSVVQGALAEVQSIVALPSGYHRDLQLTKGPTMRGLDEALATSRLLPRLVEGLAFDRERMARAITPECFATDRAVELAVEGVPFREAYRKVAAEIAALPAGDAAASLRARVSLGAPGNLALDDLARRLDRHAR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALE1_CYATE
Sequence: MVSSRMASGETILVTGGAGFIGSHTVVQLLKQGFHVSIIDNLYNSVIDAVHRVRLLVGPLLSSNLHFHHGDLRNIHDLDILFSKTKFDAVIHFAGLKGVGESVLNPSNYYDNNLVATINLFQVMSKFNCKKLVISSSATVYGQPDQIPCVEDSNLHAMNPYGRSKLFVEEVARDIQRAEAEWRIILLRYFNPVGAHESGQIGEDPRGLPNNLMPYIQQVAVARLPELNIYGHDYPTKDGTAIRDYIHVMDLADGHIAALRKLFTTDNIGCTAYNLGTGRGTSVLEMVAAFEKASGKKIPIKMCPRRPGDATAVYASTEKAEKELGWKAKYGVEEMCRDQWKWASNNPWGYQGKH
What are the official names of this protein?
UDP-glucose 4-epimerase GEPI42, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: APJ_MACMU
Sequence: MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVFRTTGDLENTTKVQCYMDYSMVATVSSDWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
What is the function of this protein?
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
What are the official names of this protein?
Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=After exposure to apelin (APLN) or apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane.
Protein: MIA40_HUMAN
Sequence: MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLILPNGNINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEEIKGSDCVDQFRAMQECMQKYPDLYPQEDEDEEEEREKKPAEQAEETAPIEATATKEEEGSS
What is the function of this protein?
Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228).  Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:30885959).  Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Required for the import of COA7 in the IMS (PubMed:30885959).  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665).  Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364).  Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Coiled-coil-helix-coiled-coil-helix domain-containing protein 4.
Protein: HXPA_ECOLI
Sequence: MRCKGFLFDLDGTLVDSLPAVERAWSNWARRHGLAPEEVLAFIHGKQAITSLRHFMAGKSEADIAAEFTRLEHIEATETEGITALPGAIALLSHLNKAGIPWAIVTSGSMPVARARHKIAGLPAPEVFVTAERVKRGKPEPDAYLLGAQLLGLAPQECVVVEDAPAGVLSGLAAGCHVIAVNAPADTPRLNEVDLVLHSLEQITVTKQPNGDVIIQ
What is the function of this protein?
Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance (PubMed:27941785).  Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate (PubMed:27941785).  Is also able to dephosphorylate other sugar phosphates in vitro including ribose-5-phosphate (Rib5P), 2-deoxyribose-5-phosphate, fructose-1-phosphate (Fru1P), fructose-6-phosphate (Fru6P), and glucose-6-phosphate (Glu6P) (PubMed:16990279).  Selectively hydrolyzes beta-D-glucose-1-phosphate (bGlu1P) and has no activity with the alpha form (PubMed:16990279).
What are the official names of this protein?
Hexitol phosphatase A, Mannitol-1-phosphatase, Sorbitol-6-phosphatase, Sugar-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: XERDL_STRS2
Sequence: MKQAIESFIQSKKVSVNSQKSYTYDLQQFVTVTKGEISQQSLLVYQQSLLDLKPAAQKRKMSAVNQFLYFLYENNLLDRFYKLQTTSGPASVKKKLEREDLTLLFQESPWLEGQLIALLIAYLGLTPSEIAELTSQQVNLDFQVLTVEKGGAKRVLTLPKELIPYMESHLSGRYVFDKKGQTYSRQWFFNRLTEFVQSIGKPDWTAQKLREQYILKQIDEGKSLDQIAKQLGLKTSMSLEKFR
What is the function of this protein?
Putative tyrosine recombinase.  Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.
What are the official names of this protein?
Tyrosine recombinase XerD-like.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD-like subfamily.
What are the subcellular locations of this protein?
Cytoplasm.