PharMolix/UniProtQA huggingface dataset:
Protein: PDX1_DICDI
Sequence: MENLTENQATNNNSPFRIKSSLAQMLKGGVIMDVVTPEQARIAEEAGACAVMALEKIPADIRHFGGVARMSDPGMIKEIMNAVTIPVMAKVRIGHFVEAQILQEIGVDYIDESEVLTIADNENHIDKSEFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVRHARAVNKEIKKIQNMDPHELYTYAKEIQAPLELVKEVKRLGRLPVVNFAAGGVATPADAAMMMQLGMDGVFVGSGIFKSGDPAKRAKAIVQAVTHFNNPQIVAKVSENLGEAMVGINVDTLKDKENQNWSTKEK
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by pdx2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Probable pyridoxal 5'-phosphate synthase subunit pdx1, PLP synthase subunit pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: ALKB_DICDI
Sequence: MYETEEDPTTSNVATTNNEKTASTAATTTEPVKKVTEFMRVQRLFRQVTKSANGKNIPKEKREPIDYSPVLDFHNLENNTEENKKLIIDCTSNVTTHDFEFNRDTEFYLHPREWKVYGLQGYPGFYFIKSPFTASQQKKWIKHALEDYADPPNNNNITLFHGPIKNLWKNGEKELINEELKSQGKHDDDEIEQPTRPLDKNGEPLPTYRQLLDKLAWSTLGYQYQWTPRLYSEEFYEEFPDDLQELVQKIAIATKFDPYVAEAATVNFYSEDSIMGGHLDDAEQEMEKPIISISFGSTAVFLMGAETRDIAPVPLFIRSGDIVIMGGRSRYCYHGVAKIVENSFDLGLIDENDDQDLKYKIQWLKEKNRRVNINTRQVFKVPKLGGKLINKNE
What is the function of this protein?
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation.  Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase alkB, Alkylated DNA repair protein alkB.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
Protein: NIFU_AZOVI
Sequence: MWDYSEKVKEHFYNPKNAGAVEGANAIGDVGSLSCGDALRLTLKVDPETDVILDAGFQTFGCGSAIASSSALTEMVKGLTLDEALKISNQDIADYLDGLPPEKMHCSVMGREALQAAVANYRGETIEDDHEEGALICKCFAVDEVMVRDTIRANKLSTVEDVTNYTKAGGGCSACHEAIERVLTEELAARGEVFVAAPIKAKKKVKVLAPEPAPAPVAEAPAAAPKLSNLQRIRRIETVLAAIRPTLQRDKGDVELIDVDGKNVYVKLTGACTGCQMASMTLGGIQQRLIEELGEFVKVIPVSAAAHAQMEV
What is the function of this protein?
Involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
What are the official names of this protein?
Nitrogen fixation protein NifU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: STYE_STYCL
Sequence: MQMKATILIVLVALFMIQQSEAGWLRKAAKSVGKFYYKHKYYIKAAWKIGRHALGDMTDEEFQDFMKEVEQAREEELQSRQ
What is the function of this protein?
Bactericidal against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Styelin-E.
What are the subcellular locations of this protein?
Secreted.
Protein: ACYP_COXBN
Sequence: MTQKEKNETCIHATVSGKVQGVFFRESVRKKAEELQLTGWVKNLSHGDVELVACGERDSIMILTEWLWEGPPQAAVSNVNWEEIVVEDYSDFRVR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RS8_PSEA8
Sequence: MSMQDPLADMLTRIRNAQMAEKTVVSMPSSKLKAAVAKVLKDEGYIADFQISSEVKPQLSIELKYFEGKPVIEEVKRISRPGLRQYKSVEQLPKVRGGLGVSIVSTNKGVMTDRAARAAGVGGEVLCTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: YBEY_DEHMB
Sequence: MEINVIVKPPFKKLVSAQFLKKIASETLKAQAADPSSELGIVITGQEEIKELNCKYRQLDEPTDVLSFYMLEENPENLTAPDDFPTPPDEATHLGEVIISYPQAELQAGAAGHSVNHELAFLLIHGVLHLLGYDHHETAAEAVMKSHQDIAMKHIREILE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_KLEP3
Sequence: MSVIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKDKLSNPVRLVKDYLDGVEVAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADLVDEAKRLLSTCDIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVGVFEFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEERAKQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_BORA1
Sequence: MTSIAAPQPGLLRQYLVLTKPRVTQLAVFCAVIGMFLAVPGLPDLKRVLFGTIGIWLLAAAAFAINCLIEQEIDARMTRTARRGTARGTISPAQVLSLSGLLGGAGMLVLYHLVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWASVANAVPAEAWVLVLIIFIWTPPHFWALALYRTEDYRKAGLPMLPITHGSKHTRLQIMLYSFALFAVTLLPYFMHMNGLLYLLAAVILGGIFVAHALRLYRSYSDERSRRLFRYSILYLALLFGALLVDHWVGVLSA
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LSRF_SALPA
Sequence: MADLDDIKDGKDFHTDKPQTNTLFALKGCGALDWGMQSRLARIFNPKTRKTVMLAFDHGYFQGPTTGLERIDINIAPLFEYADVLMCTRGILRSVVPPAINKPVVLRASGANSILTELSNEAVAVAMDDAVRLNSCAAAAQVYIGSEHEHQSIKNIIQLIDAGLRVGMPIMAVTGVGKDMARDQRYFSLATRIAAEMGAQIIKTYYVDKGFERIAAGCPVPIVIAGGKKLPEREALEMCYQAIDQGASGVDMGRNIFQSEDPVAMIKAVHAVVHHNETAERAYELFLSEKG
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30E_SACS2
Sequence: MIKVSEQQVSFEGELKSLLKTGKVIFGAKRAIKYIKLSKVKMVIVASTLRGDLKQDIMHYAKLSNIPVYEYKGSGWDLGTLCGKPFMISTISIIDEGDSKILDIIKER
What are the official names of this protein?
50S ribosomal protein L30e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: CH60_LEGPC
Sequence: MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVAKSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAKRIVVTKENTTVIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAATGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_AZOSB
Sequence: MSSHAPASSFSVSGLLAYCRAGFEKELAAEIDDLAADAGLIGYVRTEPGSGYAAFETFEPVPVIKLGEFADWRKPVFARQLLPWFDRIDDLPERDRARPLVDMVKGSGQRFSGVVLETPDTDEAKQRSGFCRRFTEPLTRELEKVGALRLGKPGFPVLHVMFPTATSAWLAAGLKDRCAPWPMGIPRLRMPSNAPSRSTLKLAEAIMTLLSDEERDSLLRAGMRAVDLGAAPGGWTWQLAQRGIRVTAIDNGPLRDTVMATEMVEHLKADGFTWRPQRPVDWMVCDMVEQPSRIASLMAEWIATGRCRHTIFNLKLPMKRRLEAVEQCRELIRKRLASIGPFDLRIKQLYHDREEVTAYLTLKK
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG16_YEAST
Sequence: MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK
What is the function of this protein?
Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy.  The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS).  Recruits also ATG3 to the PAS.  Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.
What are the official names of this protein?
Autophagy protein 16, Cytoplasm to vacuole targeting protein 11, SAP18 homolog.
What is the protein family that this protein belongs to?
Belongs to the ATG16 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: SET_RAT
Sequence: MAPKRQSAILPQPKKPRPVAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
What is the function of this protein?
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.  Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.  In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.  Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A.  Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases.  The predominant target for inhibition is histone H4.  HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA.  Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity).
What are the official names of this protein?
Protein SET, Liver regeneration-related protein LRRGR00002, Phosphatase 2A inhibitor I2PP2A, I-2PP2A, Template-activating factor I, TAF-I.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium (By similarity).
Protein: KYNU_YARLI
Sequence: MPLNFRDRFNVPVLKNGEEVAYLVGNSLGLMPHKTRDYVNQEMDAWSQLGVKGHFVSGKEDLGQDVHQGPWYSCDEPLHGLVGPILGASEDEVAIMNTLTSNIHSLFSAFYKPTAKRSKILFEAKAFPSDTYAMEAQARLHNLDPSEALIKLAPKDGLHTLSDDDIIKVIEEQGDEIAVVFFSGIQFYTGQLFDIPRITAAAKAKGCVVGWDLAHAAGNVPLKLHDWNVDFAVFCTYKYMNSGPGGIGGLFVHDKYADDQRPRLAGWWGNNAETRFKMLDEFDPIRGARGYKQSNPSVLCVLALRASLELFKEAGGIEKLRERSIELTNRLLKGLLASPHYIAPENIEIFGNSGKAWFTIITPQAEHQRGAQLSLLFGPDGTMKKVFDYLDDHGVLGDERNPDVIRLAPAPLYNNERDVDLAIKLINDSINLINGSA
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, Biosynthesis of nicotinic acid protein 5, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNC_SHELP
Sequence: MGIRAIVVDTAGTTTDLNFIQDTLFPYSSKALADFLEENQTNVLVDNCISDVKDIALEPDASLERVVEILQQWIAEDRKATPLKTLQGLIWKQGYAQGEFKGHIYPDFIDSVKEIKAQNVRLYSFSSGSVDAQKLLFSHSDGGDLTEYFDGHFDTRTGNKLFKQAYLNIINTISLAPKQVLFISDVLEELKAAEQAGMRVMQMVRETTQRTGDYPQITNFKELSF
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: LEUC_YERPB
Sequence: MGTTSSQSKTLYQKLYDAHIVHEAPNETPLLYIDRHLVHEVTSPQAFDGLRAMGRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMRIEVNGTVGAGITAKDIVLAIIGKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNMAIEMGAKAGLVAPDDTTFAYLKGRQFAPTGEQWEQGVAYWRTLKSDADAQFDTIVTLDAADIAPQVTWGTNPGQVIAVNQIIPAPESFSDPVERASAEKALAYMDLRPGIKLTEVAIDKVFIGSCTNSRIEDLRAAAAIAQGRKVAKGVQAIVVPGSGPVKAQAEAEGLDKIFIAAGFEWRLPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVSGHFADVRELSAATH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: DXS_CROS8
Sequence: MSFDTAKYPTLALVDSTAELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDRIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAAREEKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKRVFSNVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLVNTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPESGTLPKSSGGQPSYSKIFGDWLCETAAKDDKLMAITPAMREGSGMVEFSRKYPAQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPSAVRYPRGNALGVTLEPLQKLPIGKGVVKRHGEKVALLNFGTLLPEATQAAEALNATLVDMRFVKPLDEALIMELAGRHEALVTIEENAVMGGAGSGVNEVLMAKRKPVPVLNIGLPDHFIPQGTQDEARAEIGLTASGIEQRVRDWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RL9_SOLM1
Sequence: MELILRADVENLGRLGDKVSVKPGYGRNYLIPQGLAMLATPANLRRFENESKKLQAKRDALIADAKGLADRLAEIAIVIEVRVGEGAKLYGSVTTAIIADKLAELGFDIDRKKIVLAEPIRSLGHYDVPVKLLPELRGSVKVSVVRQGGPEDEEIAEAAPVAEAQAEADGHSTEETA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y4310_VIBVU
Sequence: MFDDLPPLSHQEQQRAVEEIQKLMAEGMSTAQAIKIIAEKIRAEHKAQSSK
What are the official names of this protein?
UPF0181 protein VV2_0310.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: AQP7_RAT
Sequence: MAGSVLENIQSVLQKTWVREFLAEFLSTYVLMVFGLGSVAHMVLGERLGSYLGVNLGFGFGVTMGIHVAGGISGAHMNAAVTFTNCALGRMAWKKFPIYVLGQFLGSFLAAATTYLIFYGAINHYAGGELLVTGPKSTANIFATYLPEHMTLWRGFVDEVFVTGMLQLCIFAITDKLNSPALQGTEPLMIGILVCVLGVSLGMNTGYAINPSRDLPPRFFTFIAGWGKKVFSAGNNWWWVPVVAPLLGAYLGGIVYLGLIHAGIPPQGS
What is the function of this protein?
Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9252401).  The channel is also permeable to urea (PubMed:9252401).  Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids.  Mediates glycerol export from adipocytes.  After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia.  Required for normal glycerol reabsorption in the kidney (By similarity).
What are the official names of this protein?
Aquaporin-7, AQP-7, Aquaglyceroporin-7.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lipid droplet. Note=Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (By similarity).
Protein: CYB_MESHI
Sequence: MTNIRKSHPLAKIINHSFIDLPAPSNISAWWNFGSLLGVCLALQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWLIRYAHANGASMFFIFLYFHIGRGIYYGSYTFMETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVAIHLLFLHETGSNNPSGLTSDSDKIPFHPYYTIKDILGLLFMLLALMMLILFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILMLFPSLHMSKQRSMSFRPLSQCLLWILVANLIILTWIGGQPVEYPFISIGQMASISYFCIILILMPATSLMENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: M2_I72A5
Sequence: MSLLTEVETPTRNGWECKYSDSSDPLVIAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: TA2R4_HUMAN
Sequence: MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
What is the function of this protein?
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.  In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
What are the official names of this protein?
Taste receptor type 2 member 4, T2R4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Protein: DRE2_CRYNJ
Sequence: MPAPVPPTAFAQPSGPATQLVLGSMQRAPEYQALLTSLKSAAPPSSSVQGEMVDRILDNATTLPPPPLTIHLVLPLPLPSNLLSAIPPSTQIFIHIPADSESQLGALHSALASHSFTPVLPTPSPSTLAYTSPSAPSLPAVASEPSPAPSSSTPVTLSGARPLQLRRNGDKARKAALWAIDSPLIPDGGKSLLTPADRTRPDCVFPAENGKPVKRRRACKDCTCGLKELEQEEEAQTSAAVQEAQKAFFLEGDDDIPENLKKATEGMEGIWPADKRAEAKKTSSCGSCYLGDAFRCSSCPYLGLPPFKPGEQVQVSIGDDI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: SPXH_STAAS
Sequence: MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHILNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMICDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVEGLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKKLAIQQKIEKLKYPDGDFWKSKMPKIKSK
What is the function of this protein?
Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions.  Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.
What are the official names of this protein?
ClpXP adapter protein SpxH.
What is the protein family that this protein belongs to?
Belongs to the SpxH family.
What are the subcellular locations of this protein?
Cytoplasm.