PharMolix/UniProtQA huggingface dataset:
Protein: CAS2C_CHLAA
Sequence: MKMFTVISYDIVDDQRRTSVMKVLKGYGVRVQYSVFEAILDAREFHDLSNQLRKIIDPGQDSIRCYRLDQVAAQRTVIYGIGLTTTDPTHYMV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2 3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: PATG_ASPCL
Sequence: MAKIDVHHHFYPQAMREALERAGGDPSGWYIPPWTLDLDKEISRVLKVQTTILSVTAPGPGIETDPGKAAALARLCNEEAAAIRDAHPLQYGFFASVPSLFDTAAVLAEIEHAFTNLHADGVTLYTRYGAGHSYLGDERFRPIWAELSKRRAVVFIHPTHAVDTQLINSWMPQPMFDYPHETGRTAMDLLTRGVIRDYPGCKIILSHAGGTLPYLIHRAATMLPFMPRNLGMSREEIVEAARTFYFDTAISANPVTLKALLEFAKPGHVLFGSDFPNAPRGAITHFTSFLEGYDNMSEETRRLVEREAALELFPRLRGQSTRACL
What is the function of this protein?
6-methylsalicylic acid decarboxylase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:24334092).  PatG catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (PubMed:24334092).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:19383676) (Probable).
What are the official names of this protein?
6-methylsalicylic acid decarboxylase, Patulin synthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SELB_ECOLI
Sequence: MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVPGFIDVPGHEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLAILQLTGNPMLTVALTKADRVDEARVDEVERQVKEVLREYGFAEAKLFITAATEGRGMDALREHLLQLPEREHASQHSFRLAIDRAFTVKGAGLVVTGTALSGEVKVGDSLWLTGVNKPMRVRALHAQNQPTETANAGQRIALNIAGDAEKEQINRGDWLLADVPPEPFTRVIVELQTHTPLTQWQPLHIHHAASHVTGRVSLLEDNLAELVFDTPLWLADNDRLVLRDISARNTLAGARVVMLNPPRRGKRKPEYLQWLASLARAQSDADALSVHLERGAVNLADFAWARQLNGEGMRELLQQPGYIQAGYSLLNAPVAARWQRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLLLIEKMRESGDIHSHHGWLHLPDHKAGFSEEQQAIWQKAEPLFGDEPWWVRDLAKETGTDEQAMRLTLRQAAQQGIITAIVKDRYYRNDRIVEFANMIRDLDQECGSTCAADFRDRLGVGRKLAIQILEYFDRIGFTRRRGNDHLLRDALLFPEK
What is the function of this protein?
Translation factor necessary for the incorporation of selenocysteine into proteins.  It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon.  SelB binds GTP and GDP.
What are the official names of this protein?
Selenocysteine-specific elongation factor, SelB translation factor.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_PSEU2
Sequence: MRDPAPSNSEMKRVIVGMSGGVDSSVSAVLLMEQGYQVEGLFMKNWEEDDGTEYCTAREDLADAQAVCDKIGIKLHTANFAAEYWDNVFEHFLEEYKAGRTPNPDILCNREIKFKAFLDYALMLGADLIATGHYVRRRDIDGRTELLKGLDPNKDQSYFLHAVGGEQIARTLFPVGELEKPEVRAIAEKHGLATAKKKDSTGICFIGERRFTDFLRQYLPAQPGEIKTTEGEVIGRHSGLMYHTIGQRQGLGIGGLKDASDDPWYVLVKDLENNELIVGQGNDHPWLFSRALVSSEIYWVNPIDLSSPRRLTAKVRYRQGDQPCTLEKTADGYRATFDDPQRAVTPGQSVVFYDGEICLGGGVIEIAEPWTTKDKR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_STAAM
Sequence: MKEIVIASNNQGKINDFKVIFPDYHVIGISELIPDFDVEETGSTFEENAILKSEAAAKALNKTVIADDSGLEVFALNGEPGIYSARYAGENKSDEANIEKLLNKLGNTTDRRAQFVCVISMSGPDMETKVFKGTVSGEIADGKYGENGFGYDPIFYVPKLDKTMAQLSKEQKGQISHRRNAINLLQAFLEGEKNV
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: PLAS_DRYCA
Sequence: AKVEVGDEVGNFKFYPDSITVSAGEAVEFTLVGETGHNIVFDIPAGAPGTVASELKAASMDENDLLSEDEPSFKAKVSTPGTYTFYCTPHKSANMKGTLTVK
What is the function of this protein?
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
What are the official names of this protein?
Plastocyanin.
What is the protein family that this protein belongs to?
Belongs to the plastocyanin family.
Protein: RL19_HERA2
Sequence: MQQAPVIHEIENEYLRKDVPEFRVGDTVRVSVKVVEGTRERIQDFEGVVIRRRRMGVNENFTVRRIASHGIGVERTFLLHSPRIDGVKLVRTGKVRQANLYYLRGRTGKAARIKERRG
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: DREB_HUMAN
Sequence: MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
What is the function of this protein?
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400).  Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400).  Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity).  Involved in memory-related synaptic plasticity in the hippocampus (By similarity).
What are the official names of this protein?
Drebrin, Developmentally-regulated brain protein.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cytoplasm, cell cortex. Cell junction. Cell projection, growth cone. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Protein: SK1_GROGR
Sequence: EQFEDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, GroGr-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOB_BART1
Sequence: MAQTHAMMSQFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMIEEPKGGRPDEGLQAVFKSVFPISDFSGTAMLEFVGYEFDLPKFDVEECRQRDLTYAAPLKVILRLIVFDIDEDTGSKDIKDIKEQGVYMGDMPLMTTNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKSHSSGKLLFAARVIPYRGSWLDIEFDAKDIIYARIDRRRKIPVTSLLMALGMDGSDILSTFYDKVTYERDGEGWRVPYSVDRFKGMKLISDLIDADSGEVVAEAGKKLTVRTAKSLAEKGLKAVKVSEDDLLGCYLAEDIVNYETGEIYLEAGDEIDEKVLKILLDVRADQINILDIDHMNIGAYIRNTLKVDKNESRQDALFDIYRVMRPGEPPTIDTAEAMFHSLFFDPERYDLSAVGRVKMNLRMDLDCPDTVRVLRQEDILAVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRIGLLRMERAIKERMSSVEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKIIDGKVTKEVIYLSAMEEAKHYVAQANSSLDSEGRFTEEFVVCRHAGEVLMAPRDHVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRAEAPFVGTGMEAVVARDSGAAVSAKRSGIVDQVDATRIVIRATEDLDPSKSGVDIYRLQKFQRSNQSTCINQRPLVHVGDRVEKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSERIVADDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVAEEALRNLDEAGIIYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTFGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQSILDRNVYARLTDMLTGKVAVEGPKGFSESKKLDSTVMGRYPRSQWWQFAVEDEKLQNEIEALRKQYDESKEALQRRFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGDLLELYQETGDILPLRQRIENLMPDDNHNEPVRQYDNESLYKLALQMKKGVSIATPVFDGAHESDINMMLEDAGLDSSGQVTLYDGRTGEPFDRPVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLALNVELDDARELIAQRVLSDRVEQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: LEC_LENCC
Sequence: MASLQTQMISFYLIFLSILLTTIFFFKVNSTETTSFSITKFSPDQKNLIFQGDGYTTKGKLTLTKAVKSTVGRALYSTPIHIWDRDTGNVANFVTSFTFVIDAPSSYNVADGFTFFIAPVDTKPQTGGGYLGVFNSKEYDKTSQTVAVEFDTFYNAAWDPSNKERHIGIDVNSIKSVNTKSWNLQNGERANVVIAFNAATNVLTVTLTYPNSLEEENVTSYTLNEVVPLKDVVPEWVRIGFSATTGAEFAAHEVHSWSFHSELGGTSSSKQAADA
What is the function of this protein?
D-mannose specific lectin.
What are the official names of this protein?
Lectin.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: LIPA_STRM5
Sequence: MTESTARSIPLQIVQGDSPSAAPLQAGVKQLGGDKINRSPVQFADAPVLRKPSWIRVRIPSGNAVQNLKAKLRENRLVTVCEEASCPNIHECFGHGTATFMILGEVCTRRCSFCDVAHGRPKPPDANEPASLGQTVADMGLKYVVVTSVDRDDLRDGGAQHFVDCISAIREKSPGTRIEVLTPDFRGKGRMERALEILAQNPPDVFNHNIETVPDLYRNVRPGADYQWSLNLLKNFKAQHPEVPTKSGIMLGLGEEFEQIKATMRDLRAHDVDMITIGQYLQPTAHHHPVLKYWTPEDYKALEDYGYELGFSHVASGPMVRSSYHADVQAKGAGVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAS_ECOLI
Sequence: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQDQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTEKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEFFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437, PubMed:28581482).  Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-succinylhomoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437).  Cannot use acetyl-CoA (PubMed:10572016).
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBPC_STRAW
Sequence: MLLSLKAATVRFGGRAVLDAVDLDVAEHETVCVLGPSGSGKSTLLRAVAGLQPLDEGQVVLGGRAMDSVPPHKRGVGLMFQDHQLFPQRDVGGNVAFGLRMHGASRSEQEGRVRELLDLVGLPGAARRAVASLSGGEQQRVALARALAPRPRLLMLDEPLGQLDRSLRERLVVELRELFTELGTTVLAVTHDQGEAFALADRVVVMRAGRIAQSGTPLEVWRQPADEFVARFLGFDNVVGATVAGEAADTPWGKVPVPEGSPQGPGTLLVRPAGVRLADATEGLRCTVAARTFRGTHVAVHLQPEDDAPRLEAACALRDAPEPGETVGVAFDVADIVVLGGASGA
What is the function of this protein?
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Fe(3+) ions import ATP-binding protein FbpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL18A_SPOFR
Sequence: MKAKGELKEYEVIGRKLPSESEPKPPLYKMRIFSPDQIVAKSRFWYFLRQLKKFKKTTGEIVSIREIPEKSPVKIKNFGIWLRYESRSGVHNMYREYRDLSVGGAVTQCYRDMGARHRARAHSIQIIKVEVIKASACRRPQVKQFHNSTIRFPLPKRVHHHKRLNTFAYKRPSTYFL
What are the official names of this protein?
60S ribosomal protein L18a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: TDRD1_HUMAN
Sequence: MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSENGNKKNNFLLCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESNSPPKEVNIKPGNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVTKEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASPHKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNFMLNQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNTEKMYRMNCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS
What is the function of this protein?
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Required for the localization of Piwi proteins to the meiotic nuage.  Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway.  May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 1, Cancer/testis antigen 41.1, CT41.1.
What is the protein family that this protein belongs to?
Belongs to the TDRD1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
Protein: TUSC_ALIF1
Sequence: MNRLGFVFQSAPHSTSKGREGLDAILAASAYSEDIQIFFIGDGVLQLLKNQEPEKILSRDYISGFKMLELYDLEEIFVCQNAMGNRGIKEEYLLIDVDSISNKDINEKLSQCDQIMVF
What is the function of this protein?
Could be part of a sulfur-relay system.
What are the official names of this protein?
Protein TusC homolog.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTU3C_STAAC
Sequence: MFKKLFGQLQRIGKALMLPVAILPAAGILLAFGNAMHNEQLVEIAPWLKNDIIVMISSVMEAAGQVVFDNLPLLFAVGTALGLAGGDGVAALAALVGYLIMNATMGKVLHITIDDIFSYAKGAKELSQAAKEPAHALVLGIPTLQTGVFGGIIMGALAAWCYNKFYNITLPPFLGFFAGKRFVPIVTSVVAIATGVLLSFAWPPIQDGLNSLSNFLLNKNLTLTTFIFGIIERSLIPFGLHHIFYSPFWFEFGSYTNHAGELVRGDQRIWMAQLKDGVPFTAGAFTTGKYPFMMFGLPAAAFAIYKNARPERKKVVGGLMLSAGLTAFLTGITEPLEFSFLFVAPVLYGIHVLLAGTSFLVMHLLGVKIGMTFSGGFIDYILYGLLNWDRSHALLVIPVGIVYAIVYYFLFDFAIRKFKLKTPGREDEETEIRNSSVAKLPFDVLDAMGGKENIKHLDACITRLRVEVVDKSKVDVAGIKALGASGVLEVGNNMQAIFGPKSDQIKHDMAKIMSGEITKPSETTVTEEMSDEPVHVEALGTTDIYAPGIGQIIPLSEVPDQVFAGKMMGDGVGFIPEKGEIVAPFDGTVKTIFPTKHAIGLESESGVEVLIHIGIDTVKLNGEGFESLINVDEKVTQGQPLMKVNLAYLKAHAPSIVTPMIITNLENKELVIEDVQDADPGKLIMTVK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in alpha- and beta-glucoside transport (By similarity).
What are the official names of this protein?
PTS system glucoside-specific EIICBA component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DLG4_HUMAN
Sequence: MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
What is the function of this protein?
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins.  Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.  Required for synaptic plasticity associated with NMDA receptor signaling.  Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons.  May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly.  May regulate the intracellular trafficking of ADR1B.  Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity).  Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723).
What are the official names of this protein?
Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Postsynaptic density. Synapse. Cytoplasm. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Presynapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4.
Protein: MDTH_ECOBW
Sequence: MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA
What is the function of this protein?
Confers resistance to norfloxacin and enoxacin.
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ALG8_DEBHA
Sequence: MSKKSFVKGPSGLPKELNNDKQWNYSLVNIWVASLALKLLLSVGYHSTDFDVHRNWLAITYNLPISKWYIENTSQWTLDYPPFFAYFEWVLASFVPDFVKRDGCLKIVEKGLYSLPTVLFQRLSVIVSEVVLFVSLQWYINSSKTHTEAKRAFVVASSLVLSPGLLIIDHIHFQYNGMLYGILVLMINSARLKKYLMCGFWFSILICFKHIYLYLAPAVFIFLLRAYCLNLNFGKTKSSNILKIVRWKNLFKLSSIVIAVFSIAFGPFIYYEVMPQLIERLFPFNRGLTHAYWAPNVWAIYSAIDRLLIQIYYRIPISRPILLKIFKFNPQYLWDTKLVNKTTRGLIGDVEFLILPTITSQLTFFLTLFYQVMALIPLFLQPTFRRFMGSLTLCGFASFLFGWHVHEKAVLVVIFPMTFLVSRDRDLLGPFNLLVSCAYISLFPLIFTCDEWLIKITYMLLWYIVYYFSLKKVVRLPKTNGGYGKVILDRVNNGYILGLVPVITIVSLIDLFEHKFEILRKLQFMKLLIISVYCGIGIISSWNGFSWLYFVDESIWTDE
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.