PharMolix/UniProtQA huggingface dataset:
Protein: ACNA_CUPNE
Sequence: MNSANRKPLPGTKLDYFDARAAVEAIQPGAYDKLPYTSRVLAENLVRRCDPATLTDSLLQLVGRKRDLDFPWFPARVVCHDILGQTALVDLAGLRDAIADQGGDPAKVNPVVPVQLIVDHSLAVECGGFDPDAFAKNRAIEDRRNEDRFHFIDWTKQAFKNVDVIPPGNGIMHQINLEKMSPVIHADNGVAYPDTCVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIVGVELTGKRQPGITATDIVLALTEFLRKEKVVGAYLEFRGEGASSLTLGDRATISNMAPEYGATAAMFFIDEQTIDYLRLTGRTDEQLKLVETYARTAGLWADSLKNAEYERVLKFDLSSVVRNMAGPSNPHKRLPTSALAERGIAVDLDKASAQEAEGLMPDGAVIIAAITSCTNTSNPRNVIAAALLARNANARGLARKPWVKSSLAPGSKAVELYLEEANLLPDLEKLGFGIVAFACTTCNGMSGALDPKIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGTDQDGKPVYLKDIWPSDEEIDAIVAKSVKPEQFRKVYEPMFAITAASGESVSPLYDWRPQSTYIRRPPYWEGALAGERTLKALRPLAVLGDNITTDHLSPSNAIMLNSAAGEYLARMGLPEEDFNSYATHRGDHLTAQRATFANPTLINEMAVVDGQVKKGSLARIEPEGKVVRMWEAIETYMDRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEVIVAEGFERIHRTNLIGMGVLPLEFKPGVNRLTLGLDGTETYDVIGERQPRATLTLVVNRKNGERVEVPVTCRLDSDEEVSIYEAGGVLHFAQDFLESSRATA
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate (PubMed:11495997).  Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2S,3R)-2-methylisocitrate.  The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity).
What are the official names of this protein?
Aconitate hydratase A, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: AGALA_NEOFI
Sequence: MYTTKSLLSTLIPIMIPLSLGSVSSPNLLPTPPMGFNNWARFMCDLNETLFLETASAMISTGLLEAGYNRLNLDDCWMAYDRAADSSLQWNTTKFPHGIPWLAYRLKTQGFHLGIYQDAGNLTCGGYPGSFGYEALDAQTFAAWGIDYLKLDGCNVFPEHSRTLEEEYKARYAHWHNVLRQMHPPLIFSESAPAYFADPANLTSWYEVMDWVPAFGELARHSTDILVYVGEGSAWDSIMVNYHYNTLLARYQRPGYFNDPDFLIPDHPGLTLEEKRSQFALWASFSAPLIVSAYIPGLSGEELAILRNEELITVDQDVLGLQATLASRGEEVDVLTRSLAHGDQLLTVLNRGDGVPVVRVPVEWMGLQRGCAYVVKNLWDGEVQVLEEEIVIRLNSHATQVYRIALPEECSTVIPTGIVFNTASGNCLTDENGERVGFEACRGSETQVWQVSELGHLHPLSRTSHCLTAGSQASVQLCTGQKNQQWTYEITGNLKNEHTKMCLTEGTGISQCGFERDSQVFGLPSGVDIKSS
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase A, Melibiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANFC_MOUSE
Sequence: MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELADSQAAGGNQKKGDKTPGSGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (PubMed:11259675).  May also be vasoactive and natriuretic (By similarity).  Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:12890708).  Binds the clearance receptor NPR3 (By similarity).
What are the official names of this protein?
C-type natriuretic peptide.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: FABA_CAUVC
Sequence: MQKNAYTFEELLACGRGEMFGPGNAQLPAPPMLMFDRIVRIEAEGGKYGKGYVEAEFDIRPDLWFFDCHFIGDPVMPGCLGLDAMWQLVGFFLGWSGGPGRGRALGVGEVKFTGQVTPDIKKVVYKIDLKRVIMRKLVMGIADGVLEADGKVIYETSDLKVGLFTPEQMA
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_METMJ
Sequence: MAHHNGPRKKTRYKFKKDLRKRGIPPVTSVIQSFEIGQRVHVVVEPSVQKGMPHRRFHGKTGTVIGQRGRAWLLEVRDGDSVKQVIARPQHLKAQKV
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: SSRP_HAEI8
Sequence: MTKKKVKPNSNTIALNKRARHDYFIEDEIEAGLELQGWEVKSMRAGKANISDSYVIFKNGEAFLFGASIQPLNVASTHIVCDPTRTRKLLLNKRELASLFGKANRDGFTIVALSLYWKSAWAKVKIGLAKGKKQQDKRDDIKEREWKVTKDRIMKNAHRRS
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: Y2992_ARATH
Sequence: MSAYTHPMERELSGLSSRGNSELGSRYSIESGCYMTSLAASIFIASLVTFGVLMITLLIALSTMLQSCENRNIAIVEAQRLDESFGYCKILSLHSQLNSLDEESELPLLCRDVALHRIKQGIYLRELNFTIQMALTYFQTIKPMNDNCDVVVIDIDDTNLLEQDSYYMKYIEEAKHQKSILILALYSKLRSQGYSMVLLSRRPETERNATIEQLKSRGYSDWSHLIMSREDTRQKEELERGHRVIGVIGNHMDVLRGQWNWQSKRLFKLPSLTYDDVLDYNER
What are the official names of this protein?
Uncharacterized protein At2g39920.
What is the protein family that this protein belongs to?
Belongs to the APS1/VSP family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ARLY_HYDCU
Sequence: MSNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQELKDIIDGLEKVQSDIEAGKMNWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVATDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGFTHLQTAQPVTFGHHMMAWFEMIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDFAIEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMSLLTLMKSQPLAYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNREATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAHGIQTGQDLSEMPLETLQAFHSSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR2_SULAC
Sequence: MKEYDIIIVGGGPIGLFATFYSGLRDMSALLIDAQDELGGQLVTIYPEKMVYDVGGYPGILAYDLAQNLIEQAKMFSPDIRLKEWVDWITRTQDNLWVIKTDKGNEFKAKTILLALGIGRITPSRLGAGGEIEYENRGVYYTVKRKKDFEEKRILIVGGGDSAVDWAINLAPVAKSITLIHRRDQFRAHESSVKQLYNIASVHTWHELKEVKGDGSKVTQAVIFDNRTKEEKTLDVDAVIISIGHKGDLGNVPRWGLNMKGRDILVNAKMETNLPGVYAAGDIASQEGVPKMALIAIGFSEAAIATSMAKKYIDPNVSIFGGHSSEIMKSRS
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SYP_ALCBS
Sequence: MRTSQYLLATVKETPADAVVTSHQLMLRAGMVRKLASGLYTWLPSGLRVLRKVEQVIREEMDRAGAQEVLMPVVQPMELWEESGRAPAYGPELLRITDRHNNPFCLGPTHEEVITDMVRNELHSYKQLPANFYQIQTKFRDEIRPRFGIMRSREFIMKDAYSFHTNMDSLADTYQIMHRAYCAIFDRLGLDYRPVEADTGAIGGAASHEFHVLAESGEDDIAFSDGSDYAANVELAEALAPTSERPAPGAAIEKVDTPNAKTIEELVTQFNLPIEKTIKTLVVKGAEEGQLVALLVRGDHELNDIKAEKLDAVATPLEFASEEEIRKAVGAGPGSLGPVDLPFTVIADRSVAVMSDFGAGANEDGKHYFNINWERDVALPQIADLRNVVDGDPSPDGSGTLTIKRGIEVGHIFQLGTKYSEALGATVLDENGKSVVMPMGCYGIGVTRVVAAAIEQNNDDRGIIWPEAIAPFQVALVPVNIKKSPRERELAEKLYAELTAMGIEVLFDDREKERLGVKLADTELLGIPHRIVIAERGMDNGVLEYKGRRDADKTEVAMDEIVAFLKEKMGMN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_NOCSJ
Sequence: MDKFTTHTGVGIPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDPSFVLNNEGYAGASVLVAGPDFGTGSSREHAVWALQNYGFKVVISPRFADIFRGNSGKAGLLAAQVDESVVQKIWDLLDEHPGTAVTVDLESRTVRAGEGVDAIEASFDIDDYTRWRLLEGLDDIGITLGHADAIASYEATRPSWRPATIHAH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: MRAZ_CORJK
Sequence: MFFGTFTPKLDDKGRLTLPAKFREELGEGLMVVKGQDRSLAVYPKAEFLVRAKKAAEASRTNPKARAFVRNLAASADEQNLDSQGRISVSVMHRDYAGLTKECVVIGNVDFIEIWDAESWADYSAEHEEDFSDGDDEVLATFL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NUOK2_GEOSM
Sequence: MLAIENYLILSAILFAIGTIGVLTRRNAIVIFMCIELMLNAVNLTFIAFSRHLGNIDGQVFVFFVMTVAAAEAAVGLALMIAFFKNRESIDVEDVNLMKL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K 2, NADH dehydrogenase I subunit K 2, NDH-1 subunit K 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX3_ALBCA
Sequence: MQKTPFHLVEYSPWPLLVSLSLTSMPLGLIYYIRFGSIYLLLYGMLLTSIIAYMWWRDIVREATYQGHHTTYVVKGLKLGMALFILSEVCFFFAFFWAYFHSSLAPSIEIGSVWPPIGITVLNVFQVPLLNTSVLLLSGVSITWAHHALTEGKYYSTLSGLFFTVLLGVYFLMLQYGEYNETSFSIADGVYGSTFFMATGFHGLHVMVGTLFLFVNLVRTYYYHFSTTHHVGFLAAAWYWHFVDVVWLFLYISIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YFBV_ECODH
Sequence: MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YfbV.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROA_BURP1
Sequence: MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRDADALKAANARDVARAKDKGHDAAFVDRLTLSDKALKTMIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLAAAGLSQDAVQVVGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVAKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLEAAGVGPLVDATDEDWRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END3_NEOFI
Sequence: MSNKKIEQWEIERYWEIFSSLANGHPRLNSSQAASVLRNSRLSDDQLEKVWDLADVDGDGELDFEEFCVAMRLVFDLVNGELQAVPRVLPDWLVPETKAHLVQAGRALSDRPEQFERIEDEDDTPGLKDGFDWYMKPSDKSKYEEIYSANRNHRGEITFESLQGLYDSLDVPDTDIRSAWNLVNPSASLAINKDATLAFLHILNYRHEGFRIPRTIPASLRASFENNKIDYQIDNARPAQRWGADGDRETPTGRKAKFGDTYLSRLGVGGKGSYTPKGTDFSDTIQDEEWEKVRLRRELSELQAKLDAANKASEGRRDRPRNDGRPNWTLIKKEALQLLEYKERELRELREGTGRAKAGQDLERLREDIRTVGEQVEGLKSHLAQRKEVLADLRSQIEEERARR
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein end3, Cytoskeletal adapter protein sagA, Endocytosis protein 3.
What is the protein family that this protein belongs to?
Belongs to the END3 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: SEPF_RENSM
Sequence: MAGALRKTMIYLGLADGDEHYEPQPEGKQTRPAQKNEEYVDQEIRHTEPASAHQASEDEYRAPVTPIKRAASNRDDSSGLRQITTVHPRSYNDAKVIGESFRDGIPVIMNVTDMGEGDAKRLVDFSAGLVFGLHGSIERVTNKVFLLSPVFVEVIGDDKKASENQASFFNQS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: AKSA_METAC
Sequence: MSESEQYSRNTLMDFIEYRPLDIEICDVTLRDGEQTPGVVFTKEQKLAVASELDSMGIEVIEAGFPVVSAYEKEIVKEIANQGYDSRICCLSRAVKGDVDAALDCDVDIVSIFIAMSDMHLKYKYHRTLEDMLGCAKEAIEYATDHGLNVRFAAEDASRTPIDRLKQAFKEVENEYKVQYVSLADTIGILNPTTTHYLVSEIFKCVNTSICIHCHDDLGMATANTLAAAEAGAKQLHTTVNGIGERAGNASLEEMLVALRVQYGIERYDTTKLTALSRMISEYSNITPSVNKAVVGQNAFTHESGIHVAAILEEPRTYELFLPEMVGGKRNLVVGKHTGTKALKGIINSIGFCLEREELCALIEKVKVCTDEKRRSISREQLEKLIAQVRQEQKPSASEKEKFSI
What is the function of this protein?
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form (R)-homocitrate.  Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate.  These reactions are part of the biosynthesis pathway of coenzyme B and biotin.
What are the official names of this protein?
Homocitrate synthase AksA, (R)-homo(2)citrate synthase, (R)-homo(3)citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: PROF_RABPU
Sequence: MAEWHKIIEDISKNNKFEDAAIVDYKTTKNVLAAIPNRTFAKINPGEIIPLITNRNILKPLIGQKYCIVYTNSLMDENTYAMELLTGYAPVSPIVIARTHTALIFLMGKPTTSRRDVYRTCRDHATRVRATGN
What is the function of this protein?
More likely to influence phosphoinositide metabolism than actin assembly.
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
Protein: ZUPT_CHLL3
Sequence: MSNFQAALLLTLLAGLSTGIGSAMALAVRHTNKRFLALSLGFSAGIMLYVSFMEIIPQSQEALSAGLSAKAGAWVSTISFFGGMLFTWAIDQMVPSFENPHEMSMIGPMTDAEKSDTRLHRMGIFTAAAIAIHNFPEGMAVFFSALSNQELGIVIASTIALHNIPEGMAVAVPIYFATKSRKRAFSLSFLSGLAEPLGALVGYTLLRPFLTPFVLGIVLASVSGIMVYISLDELLPSAEEYGEHHLAITGLIAGMAVMALSLLLLT
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIG_DINSH
Sequence: MNVTETLNEGLKRGYSITVTAAELDAKVNEKLSEAQPEIEMKGFRKGKVPMALLKKQFGQKLLGEAMQETIDGAMAKHFEDSGDRPALQPEIKMTNEDWKEGDDIEVAMSYEALPEVPDTDFSTVTLEKLVVKADEEAVNEALQNLAENAKSFETKEGAAEDGDQVVIDFLGKVDGEAFEGGAAEDYPLVLGSNSFIPGFEEQLIGTSAGEEKNVDVSFPEQYQAEHLAGKAAVFECKIKEVKAPKAAEIDDEMAKQFGAEDLETLKGQISERLEAEYAGAARAVMKRKLLDELDTLVKFELPPSLVATEAGQIAHQLWHEENPEVEGHDHPEIEPTEEHNKLAERRVRLGLLLAELGQKNEIQVTDAEMTQAIMAQARQYPGQERQFFEFIQQNQQMQQQLRAPIFEDKVVDYIFELATVTEKEISKDDLQKAVEALDDEV
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MYLIP_MOUSE
Sequence: MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKESLLAGHLQCSPEQAVELSALLAQTKFGDYNQNTAQYSYEDLCEKELSSSTLNSIVAKHKELEGISQASAEYQVLQIVSAMENYGIEWHAVRDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRSDQSPPSSPLKSSDSSMSCSSCEGLSCQQTRVLQEKLRKLKEAMLCMACCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8.  Activity depends on E2 enzymes of the UBE2D family.  Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth.  Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
What are the official names of this protein?
E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Idol, Myosin regulatory light chain-interacting protein, MIR, RING-type E3 ubiquitin transferase MYLIP.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RS11_CORGB
Sequence: MPPKARTNARRTGRRVVKKNVANGNAYIKSTFNNTIVSITDTNGAVISWASSGHVGFKGSRKSTPFAAQMAAENAARKAMDHGMKKVDVFVKGPGSGRETAIRSLQAAGLEIGSISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RECF_SHEFN
Sequence: MSLSRINIGSFRNITSASLQPCDGLNLIYGQNGSGKTSILEAIYFLGMGRSFRSHLSQRVINNDDDKLTLFAHLIDADRDCKIGLRRHRSGEIEVKIDGEKVKRLSTLAETLPIQVITPESFSLLFEGPKARRQFIDWGAFHSDPHFYQAWVNTRKVLKQRNQLLRNQSSYNQIQFWDKELVRYAEQVTDIRNQYVDSLNVLLKGIIGVFLPRIDIKVSFTRGWDSKTDFAQLLENQYSRDLAAGNTGSGPHKADLRLRVGNLPAQDALSRGQLKLLVCALRIAQGKLLKQQLDKNSIYLVDDLPSELDAQHRQLLLQLLTETGAQIFVTAIDPQAIVDSLSSPPNRMFHVEQGLVTVIE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERP44_BOVIN
Sequence: MIPGIFLSLPDLRCSLLLLVTWVFTPVTAEIISLDTENIDDILNNADVALVNFYADWCRFSQMLHPIFEEASNVIKEEYPNANQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQELHDLAEITTPDRSKRNIIGYFEQKDSENYRVFERVANILHDDCAFLAAFGVVSKPERYSGDNIVYKPPGHSAPDMVYLGSMTNFDGTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFRDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEEVQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
What is the function of this protein?
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif.  Inhibits the calcium channel activity of ITPR1.  May have a role in the control of oxidative protein folding in the endoplasmic reticulum.  Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
What are the official names of this protein?
Endoplasmic reticulum resident protein 44, ER protein 44, ERp44, Thioredoxin domain-containing protein 4.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.