PharMolix/UniProtQA huggingface dataset:
Protein: LMBD2_REOVD
Sequence: MANVWGVRLADSLSSPTIETRTRQYTLHDLCSDLDANPGREPWKPLRNQRTNNIVAVQLFRPLQGLVLDTQLYGFPGAFDDWERFMREKLRVLKYEVLRIYPISNYSNEHVNVFVANALVGAFLSNQAFYDLLPLLIINDTMIGDLLGTGASLSQFFQSHGDVLEVAAGRKYLQMENYSNDDDDPPLFAKDLSDYAKAFYSDTYEVLDRFFWTHDSSAGVLVHYDKPTNGHHYLLGTLTQMVSAPPYIINATDAMLLESCLEQFSANVRARPAQPVTRLDQCYHLRWGAQYVGEDSLTYRLGVLSLLATNGYQLARPIPRQLTNRWLSSFVSQIMSDGVNETPLWPQERYVQIAYDSPSVVDGATQYGYVRKNQLRLGMRISALQSLSDTPSPVQWLPQYTIDQAAMDEGDLMVSRLTQLPLRPDYGNIWVGDALSYYVDYNRSHRVVLSSELPQLPDTYFDGDEQYGRSLFSLARKIGDRSLVKDTAVLKHAYQAIDPNTGKEYLRSRQSVAYFGASAGHSGADQPLVIEPWIQGKISGVPPPSSVRQFGYDVARGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLSSCMHATAPGGSFVVKINFPTRPVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFGVHQHSSLTWTSGVYFFLVDHFYRYETLSTISRQLPSFGYVDDGSSVTGIETISIENPGFSNMTQAARIGISGLCANVGNARKSIAIYESHGARVLTITSRRSPASARRKSRLRYLPLIDPRSLEVQARTILPADPVLFENVSGASPHVCLTMMYNFEVSSAVYDGDVVLDLGTGPEAKILELIPATSPVTCVDIRPTAQPSGCWNVRTTFLELDYLSDGWITGVRGDIVTCMLSLGAAAAGKSMTFDAAFQQLIKVLSKSTANVVLVQVNCPTDVVRSIKGYLEIDSTNKRYRFPKFGRDEPYSDMDALEKICRTAWPNCSITWVPLSYDLRWTRLALLESTTLSSASIRIAELMYKYMPIMRIDIHGLPMEKRGNFIVGQNCSLVIPGFNAQDVFNCYFNSALAFSTEDVNAAMIPQVSAQFDATKGEWTLDMVFSDAGIYTMQALVGSNANPVSLGSFVVDSPDVDITDAWPAQLDFTIAGTDVDITVNPYYRLMTFVRIDGQWQIANPDKFQFFSSASGTLVMNVKLDIADKYLLYYIRDVQSRDVGFYIQHPLQLLNTITLPTNEDLFLSAPDMREWAVKESGNTICILNSQGFVLPQDWDVLTDTISWSPSIPTYIVPPGDYTLTPL
What is the function of this protein?
Outer capsid protein involved in mRNA capping.  Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities.
What are the official names of this protein?
Outer capsid protein lambda-2, Lambda2, Lambda2(Cap).
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus lambda-2 protein family.
What are the subcellular locations of this protein?
Virion.
Protein: BACE1_BOVIN
Sequence: MAQALPWLLLWMGSGVLPAHGSQPGIRLPLRSGLGGAPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTLGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEALASVGGSMIIGGIDHSLYMGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
What is the function of this protein?
Responsible for the proteolytic processing of the amyloid precursor protein (APP).  Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity).  Cleaves CHL1 (By similarity).
What are the official names of this protein?
Beta-secretase 1, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane raft. Lysosome. Late endosome. Early endosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity).
Protein: SLX4_ASPFC
Sequence: MCTTTDVVVLSSSPDQIRSCSLANPKCGAEKAFVLSPVSSSPSSLPSSSDLFQPPTRSRFFKPGGGNEGSSRTAREESETGTKQNDLAASRKKAAVRGGRQKRTKEQPPNESQTLFDNPEPPIPKHNGCTSKKGTGSRKKRIDAASKCTKSGSKKITGKVTKPGITETTKFENKTKIVTSDVSPGKSPANKLELEKDGLQIEVAMKRRLDWTPTKDTGKQAVALDDTGDNKTRFGELLSEYGFLKAAAVSQTDSKLSDGAPTKCRRLELVDTHNPSTSKRTSPDADSDRSNVRSTRSSRAPAAEGKSKKRSRKITTLTGRVTALYTKDCTDHLDAANTMIRASEDVSSKLLSKSLDLDSCVLAPGDAVDYLQDQDLIFGTCSQLEREDSPTMLRDMQKEICASKNSMIENRKPSSTTRAGSGLYSHTTVSRFQTQRDLWSVAARDMDGSLAEIEVLDMVDITDVSELPPKPNGELPDRSEKNDEDTVSQGESSRPIEITDDFGVEVDVRMEYLATSETKPEETAYAASEIRPMPRFADWKDSDLSRQVRLYGFKPMKNRRKMIEVLERCWKAQHSSTRTGVQYAPGKPDDGSTGKAGTIGSQMNKQSSKMDAAEKMRRESACLKEKAKSSTALEDKLSHATDRSSQMLTKSSFAHMEEIEDSEDEVIPSPSQLQSLYKRHISESRSSHPLPVSDTPSTPSSRTRTNADSDTKPSPSDSATESSLPDLASQITKAVRLQPRSFSVDCKRPSWHEKILMYDPIILEDFATWLNIEGLGLVHEDREVSAEFVRQWCESNGICCGFRKNSRRSER
What is the function of this protein?
Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit slx4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y298_METJA
Sequence: MKALILYKSIHHKNTEKIAKTIADELNADIYNIDKVSPDIIENYDLIGFGSGIYFGKHHKSIFKFLDKISKTNKKAFIFSTAGFPFLKSMFHKELRDKLKSKGFEILGEFCCKGYHTYGIFKLFGGLNKNHPNEDDIKKAKEFAKSILKN
What are the official names of this protein?
Uncharacterized protein MJ0298.
Protein: MLC1_DROSI
Sequence: MADVPKREVENVEFVFEVMGSPGEGIDAVDLGDALRALNLNPTLALIEKLGGTKKRNEKKIKLDEFLPIYSQVKKEKEQGCYEDFIECLKLYDKEENGTMMLAELQHALLALGESLDDEQVETLFADCMDPEDDEGFIPYSQFVQRLMSDPVVFD
What are the official names of this protein?
Myosin light chain alkali.
Protein: HSP1_SMILO
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RNFH_KLEP3
Sequence: MPANIRVEVAYALPEKQYLQRVTLDEGATVEQAIIASGLLALRDDIDLAKNKLGIYSRPVKLHDEVHDGDRVEIYRPLIADPKELRRQRAEKSAAK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: GRPE_SHELP
Sequence: MSKESNKAQEPQIEETEAVAVETEVVEDAASLMDELTQANFRVEELEQALAAAEAKVEEQKDSVIRAAAEVENVRRRAAIDVEKAHKFALEKFANELLPVIDNMERALQGTSSEDEATKAIYEGVELTLKTFTSAVAKFGLTQVDPQGEAFNPDHHQAIGMQPSEEFPANTVMMVMQKGYMLNERLLRPAMVMVSQGGASVDTQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_PSEA8
Sequence: MLHQLTLAEIARALADKQFSAEELTRTLLGRIRQLDPQLNSFISITDDLAIAQAKAADERRANGENGALLGAPIAHKDLFCTQGVRTSCGSKMLDNFVSPYDATVVEKLAAAGAVTLGKLNMDEFAMGSSNQSSHYGAVNNPWSLDRVPGGSSGGSAAAVAARLLPAATGTDTGGSIRQPAALTNLTGIKPTYGRVSRWGMIAYASSLDQGGPLARTAEDCALMLGVMAGFDPKDSTSVEQPVDDYLAALQKPLSGLRIGLPREYFGAGLDSRIADAVLAVVEELKTLGATVKDISLPNMQHAIPAYYVIAPAEASSNLSRFDGVRYGYRCDAPQNLEDLYKRSRAEGFGSEVKNRIMVGTYALSAGYYDAYYLQAQKIRRLIKNDFVSAFAEVDVILGPTTPNPAWKIGEKNDDPVSQYLEDIYTITANLAGLPGLSMPAGFVDGLPVGVQLLAPYFQEGRLLNVAHQYQQVSDWHTRTPAGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: VPR_HV1A2
Sequence: MEQAPEDQGPQREPYNEWTLELLEELKREAVRHFPRPWLHSLGQYIYETYGDTWAGVEAIIRILQQLLFIHFRIGCQHSRIGIIQQRRARRNGASRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: RFHPS_METJA
Sequence: MIIQTPSRIHMGLIDLNGSIGRVDGGIGLALEEPNIKIEGKESDDISIEFDKKLIEKYGEDYIKSVRDRVYNTAIKVLDVIGGEGVDLKILSLFPAHSGLGSGTQLSLAVGKLISKIYNKEMNAYNIAKITGRGGTSGIGIGAFEYGGFLIDGGHSFGKGKDKEDFRPSSASKGVKPAPIIFRHDFDWETILIIPKGEHVYGKKEVDIFKKYCPVPLNEVEKICHLVLMKMMPAVVEKNLDDFGEVINKLQYLGFKKVELSLQSDIVKDLINELHKDVYAGLSSFGPTIYAFGDKKLIVEKANDIFDKYGVYGEIIITKANNVGHKIW
What is the function of this protein?
Catalyzes the condensation of 4-hydroxybenzoate (HB) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylphenol 5'-phosphate (beta-RFH-P) (PubMed:21634403).  Also catalyzes the condensation of 4-aminobenzoate (pABA) with PRPP to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) (PubMed:15262968, PubMed:21634403).  Only 4-hydroxybenzoate is known to be biosynthesized by methanogenic archaea, but 4-aminobenzoate can be used as substrate by growing methanogens when it is present in the growth medium (PubMed:21634403).
What are the official names of this protein?
Beta-ribofuranosylphenol 5'-phosphate synthase, Beta-ribofuranosylaminobenzene 5'-phosphate synthase, Beta-RFA-P synthase, Beta-ribofuranosylhydroxybenzene 5'-phosphate synthase, Beta-RFH-P synthase.
What is the protein family that this protein belongs to?
Belongs to the beta-RFA-P synthase family.
Protein: FFAR2_MOUSE
Sequence: MTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE
What is the function of this protein?
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity.  In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.  SCFAs serve as a source of energy but also act as signaling molecules.  That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301).  Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation.  May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301).  May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779).  Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301).  In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276).  May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19917676, PubMed:19865172).  In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
What are the official names of this protein?
Free fatty acid receptor 2, G-protein coupled receptor 43, Leukocyte-specific STAT-induced GPCR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADD_GEOUR
Sequence: MKIGILGGTFNPIHNAHLRIAEEVRDRFDLGRVMFVPAASPPHKPLAGELSFDVRYRMVQLAIADNPAFTISDVEGRRGGKSYSIDTLKGLHSAFPHDEFFFIVGSDSFLDIGSWREYAAIFNLCNIVVVERPGAAVAALDAALPVAIAHEFCYYEAEKRLAHRSGYSVYSIAGTLLDISSSDIRELARLGRSIRYLVPQSVEHYIKEQRIYNDAR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: F16PA_BURP6
Sequence: MSITRRTTLSKYLIEQQRETHNLPADLRLLIEVVARACKAISYNVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLDANEWGGNLAAMASEEMETFFPIPANYPRGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGQQATEQSFLQPGTEQVAAGYAVYGPQTVFVLTTGNGVNCFTLDREVGSWVLTQSNLRIPEDTREYAINASNARHWYEPVKRYIDELNAGAEGPRGENFNMRWIASMVADVHRILNRGGIFMYPADKRTPDRPGKLRLMYEANPMSFIVEQAGGAATTGLKRILDVQPTGLHQRVPVILGSKNEVERVARYHEQAQS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_STAAR
Sequence: MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLSTYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHRL_LITCT
Sequence: MNFGKAAIFGVVLFCLLWTEGAQAGLTFLSPADMQKIAERQSQNKLRHGNMNRRGVEDDLAGEEIGVTFPLDMKMTQEQFQKQRAAVQDFLYSSLLSLGSVQDTEDKNENPQSQ
What is the function of this protein?
Ligand for growth hormone secretagogue receptor type 1 (GHSR).  Induces the release of growth hormone from the pituitary.  Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion.  Involved in growth regulation.
What are the official names of this protein?
Ghrelin.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS4_PSEP1
Sequence: MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQPVNGEVVTAIAKRYPNLPIQIGGGIRSLETIEHYVKAGVSYVIIGTKAVKQPEFVAEACKAFPGKVIVGLDAKDGFVATDGWAEVSSVQVIDLARRFEADGVSAIVYTDIAKDGMMQGCNVPFTKALAEATRIPVIASGGIHNLGDIKALLDAKAPGIIGAITGRAIYEGTLDVAEAQAFCDNYQG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGL11_ARATH
Sequence: MKLLSNSLMFLPLLALALTAVSSLKYSRNDFPPGFVFGSGTSAYQVEGAADEDGRTPSIWDVFAHAGHSGVAAGNVACDQYHKYKEDVKLMADMGLEAYRFSISWSRLLPSGRGPINPKGLQYYNNLIDELITHGIQPHVTLHHFDLPQALEDEYGGWLSQEIVRDFTAYADTCFKEFGDRVSHWTTINEVNVFALGGYDQGITPPARCSPPFGLNCTKGNSSIEPYIAVHNMLLAHASATILYKQQYKVLLSASLPSSICIAFCYVLFITQYKQHGSVGISVYTYGAVPLTNSVKDKQATARVNDFYIGWILHPLVFGDYPETMKTNVGSRLPAFTEEESEQVKGAFDFVGVINYMALYVKDNSSSLKPNLQDFNTDIAVEMTLVGNTSIENEYANTPWSLQQILLYVKETYGNPPVYILENGQMTPHSSSLVDTTRVKYLSSYIKAVLHSLSRKGSDVKGYFQWSLMDVFELFGGYERSFGLLYVDFKDPSLKRSPKLSAHWYSSFLKGTLHHPSYASS
What are the official names of this protein?
Beta-glucosidase 11, AtBGLU11.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: PP16B_MOUSE
Sequence: MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHEMPDYSMAYGNPGVADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVARSGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCRIS
What is the function of this protein?
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function.  Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (PubMed:21907835).  Involved in the regulation of the PI3K/AKT signaling pathway (By similarity).  Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity).  Involved in the regulation of endothelial cell filopodia extension (By similarity).  May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity).  Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation.  Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity).  Involved in the dephosphorylation of EEF1A1 (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory inhibitor subunit 16B, CAAX box protein TIMAP, TGF-beta-inhibited membrane-associated protein.
What are the subcellular locations of this protein?
Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (By similarity). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (By similarity).
Protein: FRSA_YERPS
Sequence: MAQANLSEILFKPKFKHPETSTLVRRTHCNHVVNIHSALDGDTANHWYRMINRLMWTWRGIDPLEIEEVLSRIACSKAEHSNNELLDTVVGYRNGNWIYEWANQGMMWQQKAMEETDPGSAGQFWLNAANLYSIASYPHLKGDELSEQAEVLSNRAYEEAAKYLPYTLKELTFPISDGGSLSGFLHMPTVGSAPFPTVLMCGGLDTLQSDYHRLFRDYLEPKGIAMLTIDLPSVGASSRWKLTQDTSYLHQQVLQALADVPWVDHQRVSVFGFRFGANVAVRLGYLEPQRVRAVACLGPIVHHLLCNSDSLRKVPDMYMDVMASRLGMADSTDETLNTEMNRYSLKTQGLLGRRCQTPMLAGFWENDPFSPKEEAKLICSSSADGKLLAIPSKPLYENFHRALLQTSEWLEDKMR
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: TM263_XENTR
Sequence: MSQTEKIEEAVPSYLCEEPPEGTVKDHPQQQPGMISRVTGGIFSMTKGAVGATIGGVAWIGGKSYEVTKTAVTSVPSIGVGIVKGSVSAVTGSVAAVGSVVSSKVSGKKKDKSD
What is the function of this protein?
May play a role in bone development.
What are the official names of this protein?
Transmembrane protein 263.
What is the protein family that this protein belongs to?
Belongs to the TMEM263 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ASSY_BRAHW
Sequence: MKKKLVLAYSGGLDTTVIIPWLKENYDYDVIAVCVDVGQGTETDGLEEKALKTGAVKYRLVKCEDEFVTDYIYPIVKAEATYEDKYLLGTSAARPLIAKKLVEVALEEGATAIAHGATGKGNDQVRFELTVKALAPNFEIIAPWREWNISSREEEIKYLEDRNIEVPMKKDDSYSRDKNLWHLSHEGLELEDPANMPNYERLLKLSNTIENAPNEGQFVELEFEKGIPTKVDGKTFSPSDLVKYLNEIGGKHAVGIVDLLENRVVGIKCRGVYETPGGTILYAAHREIEHLCLDRETLYFKHVVSHKLTDLVYSGRWFTPLREALCAFIDSTQQTVTGKVKLKLYKGNIIPAGVTSPYSLYNQSLASFTTGELYDHHDAQGFITLFGLPLKVNALMKEQAKKMGLK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH13_ORYSI
Sequence: MAAAPPPPPPPQLQSSDPSTPPQETSQVRKGKKSRGAKKPRRAAAAAAASTSSAGTMVEDPFLVLAGGKEGGFLELEEIDEADFGIFGGAVEDLGEIDRKAGKDQKKKKRKKRKRGDDDYALPGDGDLVVECEEEGEKGEKRVKKKRRSRKKRKVKEMEEKMESKEDVSDDNVEDMQDGNDMEQDNNDGLILGEDEVYAWRELRLHPLLITAVRRLGFKEPTPIQKACFPAAAHQGKDVIGAAETGSGKTLAFGLPILQRLLEEQEKAMRLSREDESTQDENSRESPLRALILTPTRELAKQVCDHLKEAAKFLRIQVVPIVGGLSMEKQERLLKRKPEIVVGTPGRLWELMSTGNQHLIKLHSLSFFVLDEADRMIERGHFHELQSIIEMLPVTNGSDEQTVGTTPSCETVPILQIKKRQTFVFSATLALSANFRKKLKRGLVTAKASASTDLSSIEALSKQARMKPNAEIVDLTKASILPEKLEESFIECSDDDKDAYLYYILSVHGQGRTIIFCTSIAALRHLSSILRVLGINVLTNHAQMQQRARMKAVDRFRESENSILVATDGFARGMDFDDVRTVIHYQLPHSTDVYIHRSGRTARKSMAGCSIALISPADKAKFYSLCKSLSKENLQQFPVDHAYMPAVMNRLTLARQIDKITRKNSQENANKSWLQRNAESMGLLLETSDSEEERVQGHKQRKATSANLQKLQQDLSELLQRPLQPKTFSRRYLAGAGVSPLLQKQLEELSKRNVKGSASVNANKGSRFVVIGQDQIEPLQALQNSGQEVCVSIDKQREKRRLAENWRRKKQKEKKSTREQKRKEKRIAKERD
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 13.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.