PharMolix/UniProtQA huggingface dataset:
Protein: OATA_STAAM
Sequence: MDTKDFKRLEKMYSPRYLPGLDGLRAFAVIGIIIYHLNAQWLSGGFLGVDTFFVISGYLITSLLISEYYRTQKIDLLEFWKRRLKRLIPAVLFLICVVLTFTLIFKPELIIQMKRDAIAAIFYVSNWWYISQNVDYFNQFAIEPLKHLWSLAIEEQFYLLFPLVITFLLHRFKPRNIIQTLFIVSLISLGLMIVIHFITGDNSRVYFGTDTRLQTLLLGCILAFIWPPFALKKDISKKIVVSLDIIGISGFAVLMTLFFIVGDQDQWIYNGGFYIISFATLFIIAIAVHPSSLFAKFLSMKPLLIIGKRSYSLYLWHYPIIVFVNSYYVQGQIPVYVYIIEILLTALMAEISYRFIETPIRKKGFKAFAFLPKKKGQFARTVLVILLLVPSIVVLSGQFDALGKQHEAEKKEKKTEFKTTKKKVVKKDKQEDKQTANSKEDIKKSSPLLIGDSVMVDIGNVFTKKIPNAQIDGKVGRQLVDATPIVKSQYKDYAKKGQKVVVELGTNGAFTKDQLNELLDSFGKADIYLVSIRVPRDYEGRINKLIYEAAEKRSNVHLVDWYKASAGHPEYFAYDGIHLEYAGSKALTDLIVKTMETHATNKK
What is the function of this protein?
Responsible for O-acetylation at the C(6)-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan.  O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance.
What are the official names of this protein?
O-acetyltransferase OatA.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUSB_SALTY
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: GAL1_STRTR
Sequence: MNTSQLREKFKEVFGVEADHTFFSPGRINLIGEHTDYNGGNVLPVAITLGTYGAARKRDDKVLRFFSANFEEKGIIEVPLENLRFEKEHNWTNYPKGVLHFLQEAGHTIDSGMDIYIYGNIPNGSGLSSSSSLELLIGVIVEKLYDIKLERLDLVKIGKQTENDFIGVNSGIMDQFAIGMGADQCAIYLDTNTLKYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECETAVSELQEKLDIQTLGELDFLTFDAYSYLIKDENRIKRARHVVLENQRTLQARKALETGDLEGFGRLMNASHVSLEYDYEVTGLELDTLAHTAWEQEGVLGARMTGAGFGGCAIALVNKDKVEDFKKAVGQRYEEVVGYAPSFYIAEVTGGSRVLD
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THOC7_DICDI
Sequence: MKLIKKLLEDEEDSFFKNKIVFKNFVIKKVFKKYLQFINVTTGNNENSSVDLQSLCTQLINEFGHLELSVQKAQTISETCTDETLYYQQLSKQREIEIENEKKEIAILKETLDYEKKQRQYKEQYLALYKAINEKPSTEQTEKEIEKAQKELNEITDQTNKTTSKLELRTKQFQLLLHTLNELEKNLDESIPFIENSNNNNNNSNSDQSNTPMES
What is the function of this protein?
May act as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.
What are the official names of this protein?
THO complex subunit 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the THOC7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle.
Protein: RL4_RALSO
Sequence: MELKLLQADGQLGTGVSASPEVFGRDYNEALVHQIVVAYQANARSGNRKQKDREEVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPEENFSQKVNKKMYRAGMRSIYSQLAREGRINVVDSLSVDAPKTKLLADKFRAMGLDSVLVITDNLDENLFLASRNLAHVLVVEPRHADPLSLVHYKKVLVTKAAVAQIEELLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RLMH_ECO27
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYO1_YARLI
Sequence: MAVTKRAGRRAQGGTQPAKGAQGVKKATFESGKKREVGVSDLTLLSKVSEEAINENLKKRFENGTIYTYIGHVLISVNPFRDLGIYTDAVLESYKGKNRLEVPPHVFSIAESMYYNMKSYSENQCVIISGESGAGKTEASKRIMQYIASASGGSSSNIQKIKDMVLATNPLLEAFGCAKTLRNDNSSRHGKYLEIQFNNQAEPVGANITNYLLEKGRVVGQIRNERNFHIFYQFAKAASENYRSTFGIQPPEAYTYTSASGCTSVNGINDEAEFKETLAAMNLIGLTQAEQDNLFKLLAAILWIGNMSFVEDKDGNAAIADVSVPNFVAYLLEVDAESVVKAVTQRIMETSRGGRRGSVYEVALNIAQATSVRDALAKGIYNNLFDWIVERVNQSLRAPQDAARTIGILDIYGFEIFESNSFEQICINYVNEKLQQIFIQLTLKTEQDEYVREQIAWTPINYFNNKIVCDLIEEKRPPGIFAALNDACATAHADPNAADENFIQRMSMVGQNPHFEQRQRKFVIKHYAGDVTYDVKGITDKNKDQLLKDILILLQKSGNPFLVSLFPDPVNTDNRRRPPTASDKIKKSANDLVTTLSAAQPSYIRTIKPNQNRSPTEYDEKAVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFMLLSGKTSYAGDYIWQGSAYDATLCILRDAGIPQTEYQMGTTKVFIKTPETLFALEHMRDMWWHNMAARIQRAWRRYLAYKTECAIKIQRFWRLKRGLDGLKEIQFRDSGHKLLGGRKERRTYSLIGYRRFQGDYLGCNNGSGFGDFLMKQIGVTDKVFFSCRGQLQQSRLGRSSVRVPRTFILTKNNFYVVAQQIHQKQLVVTNEYTIPVRNITHMSMSNLRDDWFCLNQASSPYGDQLMWCVFKTELAVQLRVVKPGVDIRIGPQIDYFKKQGKKASVKFQKTTTLQTKFDMYKSGSVQVPPGAPPNSVSKETPRGRAKGSRGGAPSRPAARGNAAHTPTPGAAALGYQQHQPGSAQPASPRARKAPPPAPNSRGNGHAESAQPQAYNNLQPHYQSLVNPRSGQGQQQQQHHQAYQQPTAAQPAATSYSPAPAKAAPPPPPPAPPAAPAAPAEPTYKALYDYVANGLNQLSISAGEQVLISVKEDQGWWLAKRMDGSEEGWTPAAYLEEVQGGAAAPPPAAPTAGGASAGASLAEALKQKQQSNQTLGAGIADAIKARTGRPADDDDDDW
What is the function of this protein?
Type-I myosin implicated in the organization of the actin cytoskeleton.  Required for proper actin cytoskeleton polarization.  At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly.  Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).
What are the official names of this protein?
Myosin-1, Class I unconventional myosin, Type I myosin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.
Protein: HUTU_VIBVY
Sequence: MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAVAKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLDEALAIVKESDTPVSVGLLGNAADVFAELVERNITPDIVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESAVVKAAKQSMAVQVKAMLALQTRGAATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEELSKLK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FFT1_SCHPO
Sequence: MKRKDNKELICIPSSSPPSTPIREENYYLLTSSPIECSPIQQLDLSGSFKNYSTTSSRANGKKFGQLAMQSRIFFDTTDHKKYVESSYAAYDPHDQPPERDVSLKESSNKINPSNFFDSEQITKINAVKKRFPALDSEMIIATLEKFNWRENITIHKLTFQKLLGRGNSTINKSAQKLNNQPIEKSSVDKENAKRKRYVEEGTKQGQKKKPLRVIELSDEETNEDDLLGQSPTACTTDANIDNSIPENSDKIEEVSIESSGPSEVEDEMSEYDVRVLNFLNESTLQEIVEVSGCESKVVEYFISKRPFPSLEKAEALCQRNAHAATGKRKKSDGRNVGRKLVNSTYEVLQGFDAVDSLIAKCERYGAMISNTMRSWHNLFDDKKMEQFLNTSTGSISYEYNSQQPSSIASGITLKSYQIVGLNWLCLMYKAKLSGILADEMGLGKTCQVISFLASLKEKGIQNRHLVVVPSSTLGNWLREFEKFCPSLRVESYSGTQSERINKRYYLMDTDFDVLVTTYQLASGSRDDRSFLRKQRFDISIFDEGHYLKNRMSERYKHLMNIPANFRLLITGTPLQNNLKELISLLAFMLPKVFDNNMQGLDIIYKIKTTSDGDIERAYLSQERISRAKTIMNPFILRRRKENVLSDLPPKIQHVEYCHMEETQLSLYLSVLELKNLVNANRENILMQLRKAALHQLLFRSQYNLETLSLMSKRILREDAYLDANPQYIFEDMEVMSDFELHKLADQYRHLHPFALKGKPWMDSAKVKKLCSLLKKSRPNERILIFSQFTQVLDILEYVLNTLDLEFLRLDGSTPVETRQQLIDDFHTNENYKVFLLSTKSGGFGINLTCANIVILFDCSFNPFDDMQAEDRAHRVGQTRPVHVYRLITKNTIEENIRRLANTKLTLESSLTTDSEKIQKEISGELMKSLQMDGRVDTMDGSVV
What is the function of this protein?
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.
What are the official names of this protein?
ATP-dependent helicase fft1, Fun thirty-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LON_DESOH
Sequence: MAQPKIPEYKANGTTDKLPETVPIMPLSDGVLFPKMIIPVVITQNEYMTLIDEVMSGNRLVALITPKSGERKSDYGPGDLSPIGTLALILKMAKPDESRIHLMLQGISRIRTKNFIKTDPYLEAAFAQITENEKKDKETEGLMSNISNVYQELVRISPAIPNELGAMAVTIDEPGSLADMVASTINSSTEEKQNILETLDVKLRLKKVTRQLNHQLEILKLGDKIQSQIKEDMDKQQKEFYLRKQLKAIREELGEKEEGNVEAEEYRTKIEEGNLPEEAYKAATRELERFSRMHPSSSEYTVSSTYLDWLTTLPWDKQTEDHLDIKKARAILDKDHFGLEKPKKRILEYLAVRKLNPDSKGPILCFLGPPGTGKTSLGRSIARALGREFIRISLGGVRDEAEIRGHRRTYVGALPGRIIQEIRKAGTNNPVFMLDEIDKVGADFKGDPSSALLEVLDPEQNFSFADHYLDVSFDLSRVMFVATANVIDTIPPALRDRMEVIGLRGYTLEEKVKIARQYLIPRQRKENGLAAKHISFSQSAIRHIISDYTREAGLRNAEREIASVCRGVAAKIAEGKKVSGAIKPEDLYEYLGPVRFTSETGENALTPGVVMGLAWTPVGGEILFIEATSMKGKRGLTLTGQLGDVMKESATAALSFIRAHARDYDIDEDFFDKYDFHIHVPSGAIPKDGPSAGVTMLTALVSLLTGRKVKKGLAMTGEITLRGKVMPVGGIKEKVIAAHRAGIKEVILPRPNKKDLEEIPAKVKSAMKFHFAEKMGDVLELALNGNGATKKKKKTPAKSKKSTKPAAKKTAARKSRK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_XANOM
Sequence: MTMEAKAILRTARISPQKARLVADQVRGLSAERAVNLLKFSDKKAAHLIKKVVESAIANAENNQGADVDELKVKTIMVDEGPSLKRFMARAKGRGTRILKRTSHITVIVGAAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: 6PGD_HAEDU
Sequence: MSIKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTASKVDEFLAGEAKDTNIIGAYSLEDLAAKLEKPRKIMLMVRAGEVVDQFIDALLPHLEAGDIIIDGGNSNYPDTNRRTITLAEKGIRFIGTGVSGGEEGARHGPSIMPGGNEEAWPFVKPILQAISAKTDKDEPCCDWVGKEGAGHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLNYEEMHAIFADWKNTELDSYLIDITADILAYKDADGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITEAVFARCVSAFKDQRVAVSQLFNKTITPISDDKKEWIEAVRKALLASKIISYAQGFMLIREASENFEWNINYGATALLWREGCIIRSAFLGNIRDAYEANPGLVFLGSDPYFQNILQSAMADWRKVVAKSIEIGIPMPCMAAAITFLDGYSSEHLPANLLQAQRDYFGAHTYERTDKPRCSFFHTNWTGRGGNTASTTYDV
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: DDX31_DICDI
Sequence: MADEDDGLQLNICYLQRVPKKEINSKAEEEAYFKENISNNNNFTNNRAYREKTNKNENNLNNNKNNNNNNNNNKTYNNNNSNNSYNNNNYNNNSFNNNNNNNYNNNNSNNNNNSNNNNLNKKPTFLEKKIQQEQKQKELKELKGPQHHRYRNQENEESNAIESNSNNFKDKYKFAENKTKKDEFNRPILETIESNIKVEKSETFSSMNWGSLQLSETLVRNLVGHMKHEKPTHIQEASITPILKGNDALVKAQTGSGKTLSYLIPVVQKLTEQRVTRSDGCYCVIITPTRELSSQIYEELQKLLKPFYWIVPGIIMGGENRSAEKARIRKGINILVATPGRLLDHLQNTQSFPTDNIKWCILDEADKLLDLGFEKDVTTIINLLDSKKRTMKFKRQNILVSATLSEGISRLASLSLTSPVYIGLDSKVLEKGENPFQAAEKEMLQAPKQLDQFYVEVESKERLTSLIAFIRWKTSNITIDKGDVASGNSSANSKMIVFFSSCDSVDFHHYMFSNMKMDKERGVKRTKKEQIKQDKLIQQHKQKNSKIFQTGNESDDEESDNDDSDDSDSNNSDSETDEEKEIEKQIKEATSNPNYRVKTSVFSVPIFKLHGELDQQTRTKTFFDFKNSPNGILLTTDVSARGLDLPSVNWIVQYDPCSDTKDYIHRIGRTARLGNQGCSLLFLLPSEKKYIDHLAKFNVSVKEMKVTTILQSLFYTSDGQLKKTSKSSQLESQVHDLQLLFERFLIYDSKAKEMARCAYQSFLRSYATHKADVKSIFHISYLHLGHVSKSFALRETPTELNKMSAGIKGAKAAKKGDEDTLQKQTADFKMKNYKSVNEFSDGLNDQPLQRANFHYESASGVIHNIYQRHFNRNERDEADKNSNPKEIKEKKRRLYDKKIESNKKFKSK
What is the function of this protein?
Probable ATP-dependent RNA helicase.
What are the official names of this protein?
Probable ATP-dependent RNA helicase ddx31, DEAD box protein 31.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
Protein: RNFG_BUCAP
Sequence: MKSFKETIINACLMGFFSFFSLSSVIFVKNITNNQIKNIKEKQKNTLIQQVIPRVMYHSFEKKYFLIKDKLLGDQKKHNLWLLFKNKQAKVAVVESIAPDGYSGSISILVAAYLNGKIIGVRVLSHKETPGIGDKIEISISNWITKFQDMNVIDLKDKKFLLKKYGGKIEQFTGATITPQSVSNAVKRTVVFIKKIPLIFSL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RHAM_SALG2
Sequence: MIRKAFVMQVNADAHEEYQRRHNPIWPELEAVLKSHGAHHYAIYLDQERNLLFATVEIESEERWNAVASTDVCQRWWKHMRDVMPANPDNSPVSAELKEVFYLQ
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER1_MAIZE
Sequence: MATVLGSPRAPAFFFSSSSLRAAPAPTAVALPAAKVGIMGRSASSRRRLRAQATYNVKLITPEGEVELQVPDDVYILDQAEEDGIDLPYSCRAGSCSSCAGKVVSGSVDQSDQSYLDDGQIADGWVLTCHAYPTSDVVIETHKEEELTGA
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.  Occupies a key position both for transferring the photoreducing power to Fd-NADP(+) oxidoreductase (FNR), hence the formation of NADPH, and for mediating the cyclic electron flow around photosystem I (PSI).
What are the official names of this protein?
Ferredoxin-1, chloroplastic, Ferredoxin I, Fd I.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL332_ALKCK
Sequence: MRVQVTLACTETGDRNYITTKNKRTNPERIELKKYSPRLKRHTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PYRE_HALH5
Sequence: MKETIAQHLLDIEAVTLRPNDPFTWSSGIKSPIYCDNRLTMGYPHIRQSIAEGFEQLIRSHFPEVTVVAGTATAGIPHAAWVSDRLQAPMVYVRSKSKGHGKQNQIEGKLSSKDRVVIIEDLISTGGSVIQAADALREAGADVLGVVAIFTYGLEKGQDQLEAANLPSYVLTDYPTLLDVAIRRGDISEEELQKLQKWRENPSSQSWMNE
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PRIB_NEIMA
Sequence: MGFNNLVSLAVLIEKVFPIRYTPAGIPVLDIILKHESWQEENGQQCLVQLEIPARILGRQAEEWQYRQGVYVHVEGFLAQKSRRSLMPMLRIQNIQEYKG
What is the function of this protein?
Stimulates the DNA unwinding activity of PriA helicase, which does not seem to require single-stranded DNA-binding by PriB.  Activates DNA-dependent ATP hydrolysis catalyzed by PriA.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: RL18_ECOSM
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ERA_STRPQ
Sequence: MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALEGNNVPTLIKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: GRPE_SHESH
Sequence: MSNDSSKAKQNQVDEAVEGEIITDNENETVTGEASLMDELTQANFRVEELEQALEAATAKVDEQKDSVIRAAAEVDNIRRRAAIDVEKARKFALEKFANELLPVIDNMERALQGTDAEAEATKAVYEGVELTLKSFIGTVEKFGLTVVNPQGETFNPEHHQAIGMQPSPDFPANTVMMVMQKGYILNERLLRPAMVMVSQGGAAVDTQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUP1_DANRE
Sequence: METRGIEQMFDFQRLPNDRFILLLLLLYAPVGFCLMLLRIFIGVHVFLVSCALPDSIVRRFIVRIMCSVLGLHVQQNSPRLRDKTTRLYVCNHVTHFDHNIINLLTSCNTPLLEGPVGFLCWARGFMELGQGVGSRTELTETLHRYCSSPDTLPLLLFPEEDTTNGRTGLLKFSSWPFSVSDSIQPVALLVKRPFIAVSTPESSWLTELLWTFFVPFTVYHVRWLPPLSKEDGETHQEFASKVQGLLATELGVISTQITKADKAEHIKRKRHSAPQTAHSNLGARPRTVAQGFLGTSVGAEDSRIARLAQQVKEVLPDVPVSVITRDLLQTNCVDTTITNLLERTDQFNSEAAMTMPSGPGKAAASSTPSAMVSSPNLKPAAKSFGRSPIDRHMSLQERKEALYEYARRRYIEKHGLNKEDDL
What is the function of this protein?
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity).  Plays a role in lipid droplet formation (By similarity).  Induces lipid droplet clustering (By similarity).
What are the official names of this protein?
Lipid droplet-regulating VLDL assembly factor AUP1, Ancient ubiquitous protein 1.
What is the protein family that this protein belongs to?
Belongs to the AUP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet.
Protein: APF3_GIBF5
Sequence: MPSSTSEDITACTFIGGGVMARCMIDGLLDTYNNSVEIRVTARRSAHVGELATRYPTLVVSQGNISPILWDEPWHKLGKTPAAHVVLICTQPWATSDVCQDIRYVYSNYGFDPEPTFVTMCPGITTAQLEGWLPKGASVVRTMPNTPVAVRQGATALFANKVVTAQQASAVADIFRAVSPQISFIKQEDGIDIAASISGSSPAYVFKLLAILVEAGVSHGLAPDVAGALVKQSCLGAAMQALQDKRSLQSLIADVCVPGGSTEKAMQRLDEGEFSAVVAAAVEKSLDANRAMGKE
What is the function of this protein?
Delta-1-pyrroline-5-carboxylate reductase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475).  The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475).  L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475).  The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475).  Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475).  L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475).  L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475).  The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475).  The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475).  Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475).  The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475).  The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8).  The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate reductase apf3, Apicidin F synthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
Protein: UPPP_SALAR
Sequence: MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQREGESKGQLTLIHILLGMIPAMVLGLVFHDTIKSLFNPINVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATVLDLYKSWSFLSAADIPMFAVGFVTAFVVALIAIKTFLQLIKRISFIPFAIYRFVVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.