PharMolix/UniProtQA huggingface dataset:
Protein: AT1A1_PIG
Sequence: MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWSDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPFNSTNKYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPASKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNEQLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTPFFVTIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, axon. Melanosome.
Protein: ATPD_GRATL
Sequence: MSSQGFMSKIALPYAEALVESASSASALDQINQDLSLISEILNQSQELKTFFYNPLITTEIKKNVVSSLFTNQVHSLVIRFLLVLIDRRRIALLDVIISKYLELVYQLQSTVIAEVLTPVLLTDVQQSALINKIKDMTNSKTVKLVITIKPMLIAGFIIKIGSKTIDTSLYGRLKHISAYLNAVS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, chloroplastic, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PFD1_DICDI
Sequence: MEILDKQAFFETREKLYTLSRSLNIIKQRIQIAENDRKKCLITINELESLSSETKTYKAVGKMFVISPMTSLKTELKQQVQKDEEDVKGLINQSKYIDAQITDTERSLNELVRKK
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
What are the official names of this protein?
Probable prefoldin subunit 1.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
Protein: HLDD_GLAP5
Sequence: MIIVTGGSGFIGSNIVKALNAIGRTDILVVDNLKNGEKFVNLVDLDIADYCDKEDFIASIIAGDDFGEIDAIFHEGACSATTEWDGKYLMQNNYEYSKELLHFCLDRQIPFFYASSAATYGGRSDNFIEERKFEQPLNVYGYSKFLFDEYVRKILPEAESPVCGFKYFNVYGPREQHKGSMASVAFHLNTQILKGENPKLFEGSETFLRDFVYVEDVAQVNIWAWQNRISGIFNLGTGNAESFRAVADAVLAFHQKGQIETIPFPDHLKSRYQTFTQADLTKLRAAGYDKPFKTVAEGTKAYMEWLNR
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: GNAQ_LOLFO
Sequence: MACCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDRKGFEKIVYQNIFSAIQTLIAAMETLSLEYKDPSNNEHAEFLNSIDADSADIFEDGHVTAIKGCWTDPGMQECYDRRREYQLTDSAKYYLDDVERIHEPGYIPTLQDILRVRVPTTGIIEYPFDLYSIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNEENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMTSHLADYFPDYDGPKCDYEAAREFMMDSYMDLNEDKEKMLYYHYTCATDTENIRFVFAAVKDTILQLNLKEYNLV
What is the function of this protein?
The G(q) alpha subunit is involved in the light-dependent activation of phospholipase C.
What are the official names of this protein?
Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
Protein: KGUA_XANOM
Sequence: MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHSEHYHFVSAEEFQGMIAAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIQALLD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN157_MOUSE
Sequence: MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGNRPVAFPYAAPPPQEPVKTLRSLINIRKDTLRLVKCAEEVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVHYKRGVFQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHPDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDDVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPSSFNPIISSQTSDSEEHSSSENIPPGYEVVSLLEALNGPLTSSPAVPPLHVLGDGHLSGMLPSYGSDGYLPPVRTLSPLDRLSDCNNQGLKLKKSLSKSISQNSSVLHEEEDERSCSESDTQLSQRLSVQHPEEGPDVTPESENLTLSSSGAVDQSSCTGTPLSSTISSPEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALPSPRAASRAPSEGEETPAESPDSNFAGLPAGEQDAEGNDIIEEEDRSPVREDGQRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGEWQCAEHELGGRRPSARPRSPRGGLGKEASAFRIETVALPGTYV
What is the function of this protein?
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469).  Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469).  May act as a scaffold molecule to regulate this process (PubMed:25342469).  Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity).
What are the official names of this protein?
E3 ubiquitin ligase Rnf157, RING finger protein 157, RING-type E3 ubiquitin transferase Rnf157.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC62_SACS2
Sequence: MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSERVVILGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVDDEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIIDSLSYLDLHQLILLKALIRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIMVRLKSRA
What is the function of this protein?
Involved in regulation of DNA replication.  May play essential roles in origin recognition and cell cycle control of replication.  Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail.  Has a weak ATPase activity.  Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM.  Also regulates the DNA polymerase and the nuclease activities of PolB1.
What are the official names of this protein?
ORC1-type DNA replication protein 2.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: Y1601_STRA5
Sequence: MSITIWILLIIVALFGGLVGGIFIARKQIEKEIGEHPRLTPDAIREMMSQMGQKPSEAKVQQTYRNIVKHAKTAIKTKK
What are the official names of this protein?
UPF0154 protein SAG1601.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACYP_SOLUE
Sequence: MSKSAVSPSEARRWYVRGRVQGVGYRDFAQRAAVQLGLTGYARNLDDGRVEVYAVGPPSKLSELAGMLYRGPRWSDVRGIEEQEAAITSYDSFRIR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: EI3G1_DROSE
Sequence: MPGVETIKSSWADEVELDYGGLPPTTETVENGQKYVTEYKYNKDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGESKNDKPGPNSQTTMVSEEIFMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDTNMMEKKASAAAAAAVDAPKSGKYVPPFLKDSQKGALGMRGRDDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G-1, Eukaryotic translation initiation factor 3 RNA-binding subunit 1, eIF-3 RNA-binding subunit 1, Eukaryotic translation initiation factor 3 subunit 4-1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_ECOBW
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SYT_PSEU2
Sequence: MPTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQIITPKDQEGLEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAIEQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLVEDMPSEQAMGLYYHEEYVDMCRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEKRDHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDRSLWEKSGHWANYADNMFTTESESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGACHRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFIKLTLDVYADFGFKDIELKLSTRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCGTLQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQAVIMNITDKQADFALEVEKTLAESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREVEMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_NEIMA
Sequence: MFSKLTPLAETGIPTLSCANAAGRLLHSDSRQIKQGDIFVACPGEYADGRSYIPAAVANGAAFVFWDDDGKFAWNPEWKVPNQGIKDLKHRAGILAAQVYGNVSDGLKFWGVTGTNGKTSITQWLAQAADLLGEKTAIVGTVGNGFWGALEETTHTTPAPVDVQTLLYRFRQQGATVAAMEVSSHGLDQSRVNGVSFRSAIFTNLTRDHLDYHGTMEAYGAIKSRLFYWHGLKHAVINVDDEYGAELAGRLKKDCPDLAVYSYGFSEQADIRIIDFTASSDGIAAVFQTPWGEGKCRTRLLGRFNAQNLAACIALLCANGYPLDNVLDVLAKIRPASGRMDCIMNSGKPLVVVDYAHTPDALEKALATLQEIKPQGAALWCVFGCGGNRDRGKRPLMGAAAVQGADKVVVTSDNPRLENPHDIINDILPAVPAPECVEADRAAAIRYAVEQAAANDIILIAGKGHENYQDVQGVKHRFSDLEIVGQALLTRK
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGB2_LUPLU
Sequence: MGALTESQAALVKSSWEEFNANIPKHTHRFFILVLEIAPAAKDLFSFLKGTSEVPQNNPELQAHAGKVFKLVYEAAIQLQVTGVVVTDATLKNLGSVHVSKGVADAHFPVVKEAILKTIKEVVGAKWSEELNSAWTIAYDELAIVIKKEMNDAA
What is the function of this protein?
Provides oxygen to the bacteroids.  This role is essential for symbiotic nitrogen fixation.
What are the official names of this protein?
Leghemoglobin-2, Leghemoglobin II.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: SYM_ALIF1
Sequence: MATDPRKILVTCALPYANGSIHLGHMLEHIQADIWVRYQRLRGNDVNFICADDAHGTPIMLKAQQMGISPEEMIAAVSEEHQKDFAGFDISFDNYHSTHSDENRELASHIYLELKKNGFITSRTISQLFDPEKEMFLPDRFVKGTCPKCKAEDQYGDNCDNCGETYSPTDLINPKSAVSGATPVMKDSEHFFFDLPQFESMLKEWTRSGSLQSETANKMQEWFESGLQQWDISRDAPYFGFEIPGETNKFFYVWLDAPIGYMGSFKNLCNKRDDLNFDEYWKKDSTTELYHFIGKDIVYFHSLFWPAMLDGAGFRKPNNVFVHGYVTVNGAKMSKSKGTFIKAGTYLNHLDPECLRYYYAAKLNSRIDDLDLNLEDFTQRVNSDVVNKIVNLASRNAGFITKRFDGKLADNFVEPELYNEFIAAADRIAELYETREFGRAIREITALADKANQYIDEKAPWVLAKEEGKEQELQEVSSVGINLFRVLMAYLKPVMPELAARTEAFLNETLTWEGVAQPLVAHEITKFKALFARIDPKKVEAMIEESKEDAAIEMAAKEKAEAEKEKASQTELDKDPIADEIEFDAFEAVDMRIARIISCEEVPKANKLLKFQLDIGGETRQVFSGIKSAYKPEELEGKLTVMVANLKPRKMKFGMSEGMILAAGPGGKELWILEPHEGAQPGMRVM
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIG_RHIEC
Sequence: MTEGARSTIDQGEVNRFSAMAAEWWSPTGKFKPLHKFNPVRLGYIRDKACENFGRDPKSARPLEGLRVLDIGCGGGLLSEPVARMGASVVGADPSEKNIGIASTHAKASGVSVDYRAVTAEELAEAGETFDIVLNMEVVEHVADVELFMTTCAKMVRPGGLIFVATINRTMKAAALAIFAAENILRWLPRGTHQYEKLVRPEELEKPLAASGLEITDRTGVFFNPLSNQWKLSRDMDVNYMLLAKRPA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: PIPNB_PONAB
Sequence: MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNECMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRNQGQVRGTSAASDE
What is the function of this protein?
Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (By similarity).  Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).
What are the official names of this protein?
Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta.
What is the protein family that this protein belongs to?
Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein: YBAB_ECOLI
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YBEY_SHISS
Sequence: MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTIRVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_STAAB
Sequence: MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLRHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1H1_LOXHI
Sequence: LDMGHMVNAIGQIDEFVNLGANSIETDVSFDSSANPEYTYHGIPCDCGRNCKKWENFNDFLKGLRSATTPGNSKYKEKLVLVVFDLKTGSLYDNQANDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPDLNHYPLIKGFTDTLKQEGHPELLDKLGYDFSGNDAIGDVAKAYKKAGVSGHVWQSDGITNCLLRGLTRVKEAVANRDSGNGYINKVYYWTVDKRATTRDALDAGVDGIMTNYPDVITDVLNEAAYKSKFRVATYEDNPWETFKK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LhSicTox-alphaIA1i, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTG_ECO57
Sequence: MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN
What is the function of this protein?
Confers resistance to fosfomycin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LYSK_THEKO
Sequence: MISSEEKVEFLRKLVEIYSPTGRESEAVKFIVESFESFGVDAYVDEVGNAIAIREGKGPRILLAGHVDTVPGIIPVRIEDGVLWGRGSVDAKGPLATFFFATLESNANIIFAGLVDEEGFSKGAKNLDVPRPDYIIIGEPSGVDGVTIGYKGSLTAKFVESVEKVHGSLGVDAAERLINRWLEIKSSFGEGFDALSGRIVELHAYERDFDFYGEMVINLRTPPGYNPPKGWEILDFVPAYQVDRRSPLVRAFVRGIRRNGMRPRLKKKTGTADMNILGPRFGVDAVAYGPGDSRLDHTPHERISLSEYLLAIDVLVDVIEELKGAKERAAEESGEREAGKALSG
What is the function of this protein?
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
What are the official names of this protein?
Putative [LysW]-lysine/[LysW]-ornithine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. LysK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_BURMA
Sequence: MNAPHTPHLNEAEAAAAVEANAAELGRRALTRREQKEAYENNKLFKRLVRQVGQAIGDYNMIEHGDKVMVCLSGGKDSYALLDILLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLTKIGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYAKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIRDWDKRFPGRVDNMFNALANVVPSHLMDARLFPFAGLRATGEADPNGDIAFDEDPCGTDASAPGGAKSVSIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TR43B_MOUSE
Sequence: MESDNLQDPQEETLTCSICQGIFMNPVYLKCGHKFCEACLLLFQEDIKFPAYCPMCMQPFNQEYINDISLKKQVSIVRKKRLMEYLNSEEHKCVTHKAKKMIFCDKSKILLCHLCSDSQEHSGHTHCSIDVAVQEKMEELLKHMDSLWRRLKIQQNYVEKERRTTLWWLKSMKLREEVIKRVYGKQCPPLSEERDQHIECLRHQSNTTLEELRKSEATIVHERNQLTEVYRELMTMSQRPYQELLVQDLDDLFRRSKLAAKLDMPQGMIPRLRAHSIPGLTARLNSFRVKISFKHSIMFGYTSLRPFDIRLLHESTSLDSAETHRVSWGKKSFSRGKYYWEVDLKDYRRWTVGVCKDPWLRGRSYVATPTDLFLECLRKDDHYILITRIGGEHYIEKPVGQVGVFLDCEGGYVSFVDVAKSSLILSYSPGTFHCAVRPFFSAVYT
What are the official names of this protein?
Tripartite motif-containing protein 43B.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: RS2_METLZ
Sequence: MTDNELGIELNEPLVSVEEYLAAGVHIGTQQKDNDMKDFIYRVRSDGLYIIDIRKTDERIKQVAKFLARYEPAKIFVVTSRQYGQYPAQKFADTIGALSHVGRFIPGTLTNPKLPKYVEPSVVIVTDPIGDAQVITEAVQCGMPVIALCDINNRTNNVDLVIPTNNKGRKALSMVYFLLTKEFLRQKGIVSAMTVEDFESEF
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.