PharMolix/UniProtQA huggingface dataset:
Protein: SYV_SYMTH
Sequence: MSAEQKQGGTELAPRYDAKLVEDEYYQYWMDGGFYRAPIVEGKQPYTIVIPPPNVTGTLHLGHALNNTMIDILIRWKRMQGHPTLYLPGTDHAGLATQIRVEEDLRKSGGPTRHELGREAFVAKVWDWKERYHATITSQLRKLGVSVDWSREAFTMDERLSRAVRAFFVQLYKKGLIYQGTRITHWCPKDQTALSDIEVEYEERQGHMWHFRYPLADGSGSIVIATTRPETMLGDTAVAVNPEDERYKHLVGKMLRHPATGREIPIIADEYVDPAFGTGCVKITPFHDPNDFEIGLRHGLEMPQVIGPKGEMTEAAGKYAGLDRYECRRRIVADAEAEGWLVKVEEHQHAVGCCARCGTVIEPLISRQWYVKMKPLAEPAIRAVESGQIKIVPERFTKVYLHWMENIQDWCISRQIWWGHRIPVWYCDDCGHLTVSETDPTRCEKCGSANIRQDEDALDTWFSSALWPFSTLGWPDDTADLRYFFPTDVLVTGYDILFFWVARMIFSSLELTGKIPFHTVVLHGLVRDAQGRKMSKSLGNGVDPIDVIDQYGTDALRFMLVTGSSPGNDIRFHTERVENARNFANKLWNASRFVLMNLADWQPAAEGAALQYDVADRWIRHRFNEAARAVNELLGEYQYGEAARTIYDFIWSEFCDWYIELVKPRLYNPADPTRAAAQETLARVLEGTLRLLHPFMPYITEAIWQKLPLRSPQVETAPEIARAAGRDALPPSISVTAYPTPVEGWADAEANERMALIIDTIRALRSIRAEFRLGEHTRIDAVVMATSDQALAILNEGRAFIENLGKTGQLTIQPVAEAKPKNAAAAVVTGAEIYVPLGGLIDLPKEIERLTKELTTTGDELAKLEKKLSNEGFLTKAKPEVVEKTREEAAALAEKRQALENRLAMLRSMQG
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_SALEP
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLHDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQPERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CAV1_PANTR
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: CLPX_RALPJ
Sequence: MADKKGSTGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDEAAISEKEGGLAVKSDLPTPHEIRQSLDQYVIGQEQAKKILAVAVYNHYKRLKHLGKKDDVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQNCNYEVDKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLVEGTMASVPPQGGRKHPNQDFLQVDTTNILFICGGAFDGLEKIIMQRSDKTGIGFGAEVQSKEERDVSEVLPQVEPEDLIKFGLIPELIGRLPVVATLAKLDEAALMEILVEPKNAIVKQYQKLLAMEGVELEIRPSGLTAIARKAIKRKTGARGLRSIVEHALMDVMYDLPNHKGVQKVVIDESTISDEGKPLLIYEEQPKVAGSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NUOI_RALSO
Sequence: MLLAIKEFFNSLLLKELFKGLALTGRYLFARKITVLFPEEKTPLSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITIESDQRDDGTRRTTRYDIDLTKCIFCGFCEEACPVDAIVETHILEYHGEKRGDLYFTKDMLLAVGDRFEPEIAANKAADAKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SLYX_XANC8
Sequence: MHEQLSPRDQELEARLVELETRLSFQEQALTELSEALADARLTGARNAELIRHLLEDLGKVRSTLFADAADEPPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: TM262_MOUSE
Sequence: MRWRDRIAVLCFPPGLMLTVAALILFFIHMGVFASDVHNFCVIHNYDHMSFRYTVVLIFSQVISIGWAAMGSLYAEMTGDKFLRCFALTILILNGAMFFNRLCLEFLAINYREERH
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
What are the official names of this protein?
Cation channel sperm-associated auxiliary subunit TMEM262, Cation channel sperm-associated auxiliary subunit eta, Transmembrane protein 262.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Protein: Y2233_BACC1
Sequence: MSNAYEEYMRQMVIPMRQELVRSGFEELTTEEAVTEFIENTTGTTLVVVNSVCGCAAGLARPSAGQAVVRAEKQPDHLVTVFAGQDKDATAKMREYFGEIPPSSPSMALLKGKEVVHFIHRHEIEGATMDEIITNLEQAFEKNC
What are the official names of this protein?
UPF0403 protein BCE_2233.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: LYSQ_ECOLI
Sequence: MNTKIRYGLSAAVLALIGAGASAPQILDQFLDEKEGNHTMAYRDGSGIWTICRGATVVDGKTVFPNMKLSKEKCDQVNAIERDKALAWVERNIKVPLTEPQKAGIASFCPYNIGPGKCFPSTFYKRLNAGDRKGACEAIRWWIKDGGRDCRIRSNNCYGQVIRRDQESALTCWGIEQ
What is the function of this protein?
Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.
What are the official names of this protein?
Probable prophage lysozyme, Endolysin, Lysis protein, Muramidase, Probable lysozyme from lambdoid prophage Qin.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
Protein: HOX2_ORYSI
Sequence: MMDLGLSLGLGLASQGSLTSSTTTTSSPGAGSSSPWAAALNSIVGDVRRDQAAAHAAAAVGVGVGGEEMYQGRASTSPDSAAALSSASGKRERELERSGSGVDDDDGADGAGGRKKLRLSKDQAAVLEECFKTHSTLNPKQKVALANRLGLRPRQVEVWFQNRRARTKLKQTEVDCEYLKRWCERLADENKRLEKELADLRALKAAPSPASASAMQPSSSAAATLTMCPSCRRVATAGAPHQPNHQQCHPKSNTTISSSSTAAAAVAVAGGNVLPSHCQFFPAAAAAADRTSQSTWNAAAPLVTRELF
What is the function of this protein?
Probable transcription factor that binds to the DNA sequence 5'-CAAT[GC]ATTG-3'.
What are the official names of this protein?
Homeobox-leucine zipper protein HOX2, HD-ZIP protein HOX2, Homeodomain transcription factor HOX2, OsHox2.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class II subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2111_ALISL
Sequence: MSDNGFLFRFKDGQTYMDTWPERKELAPMFPEQRVIKATKFAVKVMPAVAVISVLTQMVFNNSAALPQSIIIALFAISMPLQGFWWLGNRANTKLPPALVNWYRELYQKIIESGAALEPLKQRPRYKDLANILNKAFKQLDKTALERWF
What are the official names of this protein?
UPF0208 membrane protein VSAL_I2111.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRR37_ORYSJ
Sequence: MMGTAHHNQTAGSALGVGVGDANDAVPGAGGGGYSDPDGGPISGVQRPPQVCWERFIQKKTIKVLLVDSDDSTRQVVSALLRHCMYEVIPAENGQQAWTYLEDMQNSIDLVLTEVVMPGVSGISLLSRIMNHNICKNIPVIMMSSNDAMGTVFKCLSKGAVDFLVKPIRKNELKNLWQHVWRRCHSSSGSGSESGIQTQKCAKSKSGDESNNNNGSNDDDDDDGVIMGLNARDGSDNGSGTQAQSSWTKRAVEIDSPQAMSPDQLADPPDSTCAQVIHLKSDICSNRWLPCTSNKNSKKQKETNDDFKGKDLEIGSPRNLNTAYQSSPNERSIKPTDRRNEYPLQNNSKEAAMENLEESSVRAADLIGSMAKNMDAQQAARAANAPNCSSKVPEGKDKNRDNIMPSLELSLKRSRSTGDGANAIQEEQRNVLRRSDLSAFTRYHTPVASNQGGTGFMGSCSLHDNSSEAMKTDSAYNMKSNSDAAPIKQGSNGSSNNNDMGSTTKNVVTKPSTNKERVMSPSAVKANGHTSAFHPAQHWTSPANTTGKEKTDEVANNAAKRAQPGEVQSNLVQHPRPILHYVHFDVSRENGGSGAPQCGSSNVFDPPVEGHAANYGVNGSNSGSNNGSNGQNGSTTAVNAERPNMEIANGTINKSGPGGGNGSGSGSGNDMYLKRFTQREHRVAAVIKFRQKRKERNFGKKVRYQSRKRLAEQRPRVRGQFVRQAVQDQQQQGGGREAAADR
What is the function of this protein?
Probable transcription factor involved in the regulation of flowering time under long day (LD) conditions.  Functions as repressor of flowering.  Controls flowering time by negatively regulating the expression of HD3A (PubMed:23713079, PubMed:25378698).  Acts downstream of the phytochrome B to repress the expression of EHD1, an activator of the flowering promoter genes HD3A and RFT1 (PubMed:25378698).  Controls photoperiodic flowering response.  Seems to be one of the component of the circadian clock.  Expression of several members of the ARR-like family is controlled by circadian rhythm.  The particular coordinated sequential expression of PRR73, PRR37, PRR95, PRR59 and PPR1 result to circadian waves that may be at the basis of the endogenous circadian clock (By similarity).
What are the official names of this protein?
Two-component response regulator-like PRR37, Protein DAYS TO HEADING 7, Protein HEADING DATE 2, Pseudo-response regulator 37, OsPRR37.
What is the protein family that this protein belongs to?
Belongs to the ARR-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL36_LACCB
Sequence: MKVRPSVKKMCEHCKVVRRKGRVMIICSANPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: NDK_METPE
Sequence: MDRTFVMIKPDGVQRGLIGQIVARLEDKGLKMVAARFERLAEATVNEHYREHIERSFYPSLKQYIMSGPCFLMVWEGKNAAAVVRTLTGATNPSEAAPGTIRGDYGLDIGRNVIHASDAPESAAREIALHFPGTGQVTYTRIDEPVLYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_CLOBL
Sequence: MTITMLKSKIHRATVTEANLNYVGSITIDKYLMDKANILEYEKVQIVDIDNGNRFETYVIAGEKHSGVICLNGAAARMVQKGDKIIIMSYCSLTIDEANKFNPTVLFVDNKNNIEKLTNYEKHGEII
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_POPAL
Sequence: MKNITDSFVSLGHWSSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELRGGAIEQLEKARARLRKVEIEADQFRVNGYSEIEREKLNLINSTYKTLEQLENYKNETIHFEQQRAINQVRQRVFQQALQGALGTLNSCLTNELHLRTISANIGMFGAMKEITN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: WFDC8_HUMAN
Sequence: MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPRR
What are the official names of this protein?
WAP four-disulfide core domain protein 8, Putative protease inhibitor WAP8.
What are the subcellular locations of this protein?
Secreted.
Protein: PEDF_MOUSE
Sequence: MQALVLLLWTGALLGHGSSQNVPSSSEGSPVPDSTGEPVEEEDPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST
What is the function of this protein?
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells.  Potent inhibitor of angiogenesis.  As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
What are the official names of this protein?
Pigment epithelium-derived factor, PEDF, Caspin, Serpin F1, Stromal cell-derived factor 3, SDF-3.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted. Melanosome.
Protein: CB080_MOUSE
Sequence: MERRLVKQEVKRLLGEYIGIRLRENEFDPKGRGQLTFLDDMVNQVTLAHYDLAISVASQWLDCSENLTWLQWEKVRAPLHVRPAYPNRKEREAMILSSYAGVLMNSIPIEEVLKIYGANSSASPDSTKVAQALLPRRSLHPFAMLTAPRAAECNRRQSVKLRRGATNKNTTSSSTKKATGQNGDPVGKGTHTPATNISPTPVLSSAQPFHSSTVMWRNLESAQRQMGLEGK
What are the official names of this protein?
Uncharacterized protein C2orf80 homolog.
Protein: CYSH_CROS8
Sequence: MSVLDLHALNALEKDARAGALADTNAQLEALSAEARVSWALENLPGEFVLSSSFGIQAAVCLHLVTQQRPDIPVILTDTGYLFPETYRFIDELTEKLNLNLKIYRAEQSPAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRRDQSGSRANLPVLGVQRGVFKILPIIDWDNRTVYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK1_SOLLC
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLEQDPESKVACETCTKTNLVMVFGEITTKAIVDYEKIVRDTCRNIGFVSDDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYSNDNGAMVPIRVHTVLISTQHDETVTNDEIARDLKEHVIKPVIPEKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDREILKIVKENFDFRPGMMSINLDLKRGGNRRFLKTAAYGHFGRDDPDFTWEVVKPLKWEKPQD
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATLE_CYCAE
Sequence: QGVNIYNISAGTSVDLAAPVTTGDIVTFFSSALNLNAGAGNPNNTTLNLFAENGAYLLHIAFRLQENVIIFNSRQPDGPWLVEQRVSDVANQFAGIDGKAMVTVFDHGDKYQVVINEKTVIQYTKQISGLTLSLSYNATEETSIFSTVVEAVTYTGLA
What is the function of this protein?
Anti-tumor lectin with DNase activity.  Inhibits the growth of several tumor cell lines in vitro.  Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model.  Induces apoptosis in HeLa cells.  Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).
What are the official names of this protein?
Anti-tumor lectin, AAL.
Protein: SYA_YEAST
Sequence: MTSTTGLRNLTLSFKKQLTTSTRTIMTIGDKQKWTATNVRNTFLDYFKSKEHKFVKSSPVVPFDDPTLLFANAGMNQYKPIFLGTVDPASDFYTLKRAYNSQKCIRAGGKHNDLEDVGKDSYHHTFFEMLGNWSFGDYFKKEAITYSWTLLTEVYGIPKDRLYVTYFEGDEKLGLEPDTEARELWKNVGVPDDHILPGNAKDNFWEMGDQGPCGPCSEIHYDRIGGRNAASLVNMDDPDVLEVWNLVFIQFNREQDGSLKPLPAKHIDTGMGFERLVSVLQDVRSNYDTDVFTPLFERIQEITSVRPYSGNFGENDKDGIDTAYRVLADHVRTLTFALADGGVPNNEGRGYVLRRILRRGARYARKYMNYPIGNFFSTLAPTLISQVQDIFPELAKDPAFLFEILDEEEASFAKTLDRGERLFEKYASAASKTESKTLDGKQVWRLYDTYGFPVDLTELMAEEQGLKIDGPGFEKAKQESYEASKRGGKKDQSDLIKLNVHELSELNDAKVPKTNDEFKYGSANVEGTILKLHDGTNFVDEITEPGKKYGIILDKTCFYAEQGGQEYDTGKIVIDDAAEFNVENVQLYNGFVFHTGSLEEGKLSVGDKIIASFDELRRFPIKNNHTGTHILNFALKETLGNDVDQKGSLVAPEKLRFDFSHKKAVSNEELKKVEDICNEQIKENLQVFYKEIPLDLAKSIDGVRAVFGETYPDPVRVVSVGKPIEELLANPANEEWTKYSIEFCGGTHVNKTGDIKYFVILEESGIAKGIRRIVAVTGTEAFEAQRLAEQFAADLDAADKLPFSPIKEKKLKELGVKLGQLSISVITKNELKQKFNKIEKAVKDEVKSRAKKENKQTLDEVKTFFETNENAPYLVKFIDISPNAKAITEAINYMKSNDSVKDKSIYLLAGNDPEGRVAHGCYISNAALAKGIDGSALAKKVSSIIGGKAGGKGNVFQGMGDKPAAIKDAVDDLESLFKEKLSI
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, mitochondrial, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
[Isoform Cytoplasmic]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.
Protein: REV_SIVEK
Sequence: MAGRSGVNDEELLRAIRVIKILYQSNPYPNDSGTRQARKNRRRRWRARQRQIRALSERILSSCVGGLQEPSTLPLPPLDRLSLNPEEDLGTSETEHPQGTATT
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: ERPA_BORBR
Sequence: MNAVTETVDLQAPPPVPLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDLEGAQFVIRNPNASTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: HBB1_BORSA
Sequence: MVEWTATERTHIEAIWSKIDIDVCGPLALQRCLIVYPWTQRYFGSFGDLSTDAAIVGNPKVANHGVVALTGLRTALDHMDDIKATYATLSVLHSEKLHVDPDNFRLLCDCLTIVVAGKFGPTLRPEMQAAWQKYLSAVVSALGRQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ODP2_STAEQ
Sequence: MAFEFRLPDIGEGIHEGEIVKWFIKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVLVDEGTVAVVGDVIVKIDAPDAEEMQFKGHGDDEDSKKEEKEQESPVQEEASSTQSQEKTEVDESKTVKAMPSVRKYARENGVNIKAVNGSGKNGRITKEDIDAYLNGGSSEEGSNTSAASESTSSDVVNASATQALPEGDFPETTEKIPAMRKAIAKAMVNSKHTAPHVTLMDEIDVQELWDHRKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEVVHKHYWNIGIAADTDKGLLVPVVKHADRKSIFEISDEINELAVKARDGKLTSEEMKGATCTISNIGSAGGQWFTPVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLLNNPELLLMEG
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: HIBC6_ARATH
Sequence: MIIIKTLSHRIFFPKFSQTFSSQFHQTLRFSISDRRKFSAMAGAGVDDFVKGNVFPNGVALITLDRTKALNAMNLDMDIKYKSFLDEWESDPRVKCVIVEGSTSRAFCAGMDIKGVAAEIQKDKNTPLVQKVFTAEYTLICAIAAYKKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGGGSVGAYLGLTGKRISAPSDALFVGLGTHYVPSEKLASLKEAILSANLSEDPNQDIQATLSKYSSNPESEAHLKSLLPHIESAFSSNKSIKETIEELKKYQQSTESSVVEWANEALKGLEKGAPFSLYLTQKYFSNVACAKSKPENELATLNGVMKTEYRIALRSALRGDFAEGVRAVLIDKDQNPKWNPTSIEEVDENEVEALFKPLSPEVEELKV
What are the official names of this protein?
3-hydroxyisobutyryl-CoA hydrolase-like protein 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.