PharMolix/UniProtQA huggingface dataset:
Protein: MDM2_MESAU
Sequence: STDGAEGTSQIPASEQETLVRPKPLFLKLLKSVGAQKDTYTMKEIILSWQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKDHRKIHIMIYRNLVVVSQQETLQSGTSVSESRCQPEGGSEQKDPVQEPQEEKSSSDSVSRPSTSSRRRTISETEENADELPGDRQRKRHRSLSFDESLALCVLREICCERSSSSESTDTPSNQDLDDGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEGGQELSDEDDEVYRVTVYQSGESDVDSFEGDPEISLADYWKCTSCNEMNPPLPPLCNRCWTLRENWLPEDKEKDRGDASEEAKLEAEGLDVPDGKKATSSDSKESCTEENDDKEIYTSQSQESEDYSQPSTSSSIVYSSQEDVKEWEKEETADKEENVESGFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFPCAKKLKKRNKPCPVCRQPIQMI
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.  Also acts as a ubiquitin ligase E3 toward itself and ARRB1.  Permits the nuclear export of p53/TP53.  Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.  Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation.  Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53.  Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.  Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus.  Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.  Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells.  Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).  Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity).  Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2.
What is the protein family that this protein belongs to?
Belongs to the MDM2/MDM4 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus (By similarity).
Protein: MDH_ALKEH
Sequence: MKAPVRVAVTGAAGQIGYSLLFRIASGDMLGKDQPVILQLLEITPALEALKGVVMELEDCAFPLVSGITTSDKAEEAFKDADIALLVGARPRGPGMERKDLLEANAAIFSAQGKALNDAASRDVKVLVVGNPANTNSLIAQRNAPDLDPRNFTAMTRLDHNRAVAQLANKTGAHNTEIKNMIIWGNHSATQYPDISKTKVKGEAAPGLVERDWYENDFIPTVQQRGAAIIKARGASSAASAASSAIDHIRDWVLGTPEGEWTSMAVPSDGSYGIEKGIIYSYPCVCRNGDYEIVQDLEIDEFSREKMQATEKELVEERDAVEHLLP
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: EEPD1_MOUSE
Sequence: MGSTLGCHRSIPRDPSDLSHNRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGNSAQHSPSSLRRDLLAEQQPHHLTTTVPLTPRVNINTATLAQLMSVRGLSEKMALSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISMRPSVEAFGGMRDGRPVFRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDKEALEKFCTELNQPILPNIRKWKGSRGCWRSIVAEKPSNQLQKGPCYSGFLWDTAANVELRDIPGRESSPSNGHAKAVGPSPFLARFKVGSNDLTLVNLQLTALALPGAENSSKNHSDGHRLLNFALTLQETLKGEKDVVILGDFGQGPDSNDYDILRREKFHHLVPAHTFTNISTRNPQGSKSVDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAELYMEKDWSKKEVPRNGNGVTLEPSEANIKHER
What are the official names of this protein?
Endonuclease/exonuclease/phosphatase family domain-containing protein 1.
Protein: MSBA2_COLP3
Sequence: MTQVSKTIAKPSGNANLYSRLFSYYRVYKKLIFIALAGLCLFSFVDAGMIYFVKPLIDQGLSKADSHTLQLGALLVVAIFFLRGIASFTSSYAIAYISSKVTYRIRQQAFDKLLYLPRTYFDLNSRGSLISKIIYDTEQLSQSFSSAVVIAIRESVIILVLFSMMVYNSWQLTAIFLVIVPIIALIINKVSKRFKNISHKLQNSMGQVSNKTEQAILNQQEIVLLDTRTQISAQFEKTNNNNRQQNMKLQATSAISNPVIQLIASFAIAAVLLLASIDQVLNQLTPGSFTLILIAMGSLLKPLKQLSNINQQLQKGLIAAKSLFSFLDQQEEHDIGTKQLSKTCSNIRFNNFSFTYQGKTQPALSNFSLQIKGGTSVAFVGESGSGKSTLARLLLRLYQSPKQSILINDIAIEDYSLSSLRAQFAFVSQDIVLIDDTLANNISFGCNRDVTDSEIEQAAINANVMAFAKELPLGLNSEIGENGRNLSGGQRQRIAIARAMLRDASIIVLDEATSALDNHSEKHIQQALTRLTQHKTVLIIAHKLSSIQHVDEIIVINKGRLIEQGNHKTLQAKAGYYQSLYQSQ
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase 2, Lipid A export ATP-binding/permease protein MsbA 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GAG_OMVVS
Sequence: MATQGSKEKKGYPELKEVIKTTCKIKVGPGKETLTEGNCLWALKTLDFIFEDIKTEPWTLTKMYTVWEKLKQVTPEETSKREFASLQATLACIMCSQMGMRPETVQAARGIISMKEGLHEKQEDKEKKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVTFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLAMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQLCLQWVITALRSVRHMSHRPGNPMLIKQKNSESYEDFIARLLEAIDTEPVTDPIKTYLKVTLSFTNASTDCQKQMDRVLGTRVQQASVEEKMQACRDVGSEGFKMQLLAQALRPPRKEGKQGVQKCYYCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKGNPTSQQGNSRRGPRVVPSAPPML
What are the official names of this protein?
Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the Ovine/caprine lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p16]: Virion. SUBCELLULAR LOCATION: [Capsid protein p25]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion.
Protein: ENDOU_XENTR
Sequence: MESNRTRGLNHELSKLFNELWDADENRMKAGKDYRISLQGKAGYVPAGSNQARDSASYPLFQFVDEEKLRSRKTFATFISLLDNYEMDTGVAEVVTPEEIAENNTFLDAILETKVMKIAHDYLVRKNQAKPSRNDFKAQLYTIWFQLYSRAPGQGPDSCGFEHVFVGESKRGKEIMGLHNWVQFYLQEKRKTIDYKGYVGRQNKSRPDHDDQVLNLQFSWKEMVKPIGSSFIGVSPEFEFALYTVVFLTSQEKMTREVVRVEEYEMQIVVNRHGRYIGTAYPVLLSTNNPDLY
What is the function of this protein?
Poly(U)-specific endoribonuclease involved in the processing of intron-encoded box C/D snoRNAs, such as U16 and U86.  Releases products that have 2',3'-cyclic phosphate termini at the 3'-end.
What are the official names of this protein?
Poly(U)-specific endoribonuclease, Protein endoU, Uridylate-specific endoribonuclease, XendoU.
What is the protein family that this protein belongs to?
Belongs to the ENDOU family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IF5A_HALS3
Sequence: MAKEQKEVRDLQEGNYVMMEDAACQINAYSTAKPGKHGSAKARIEAEGVFDGKKRSLSQPVDAKIWVPIVNRKQGQIVSKESDTVAQVMDLETYETVTMQIPGELDIQADENIEYLEFEGQRKILQE
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_CHLTE
Sequence: MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFAGHSTTLPMTVDEMIYHAKAVVRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKYGSYKVRAMEEEEARQLIEDAKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFRPRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_ECOLC
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPEVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMS22_CHICK
Sequence: MDSFTPPLLSDSLQMAMEVENEKSNPPCFSCIFDNQNGGRSFSGESYLASGSLKRVLLRLDPSPNDYEEDAIEMFGFQWVTETALVESCGLLFGLLRQQIYKLEDLIEMNSSDFGKAANLHSEAENIRRLCINFLHYVKVFIFRYLEPPKTENDGVLHPYEELEAQFPSLLVEELHSLTLHIGHLCELPSNVLAAFTIQHQAKIFPPSWHLLHLHLDIHWLVLEILHVLSEKMMRQVVYANHFINLTGENLTNISLFETHCENLISDLISLSIQKYTKVRPSEALTSHHYPCNCIKELWILLIQLLGFRNKGSQTECFWSLVNKKLKSIFERPTSSESVSVFGTTQCKDPLSFSLWIVTHLASLYQFDRNGNLEEKKQKESNWKFVEELLKNSIGAQTGVLEEHLRMHLQCCLTLCRFWDWNLSVITILWDYYSKNLNSCFTVPWLGLKGLASISKTSLSMLELVKSCCCEQQIPTLYKSSNSYLIFLSILARMMKEEAESSGVHPWKQIKGRIYSKFHRKRMQELTEVGLQNFFNLFLLLAIVAETEDIVSRVLDLLDFLTPSLVSPSQRALIWRGHFAFLLIYVEKNMDISVLAEKLSNAFRVKAKEFLVTKNDYTQKQNLWTLISTYIDGVQEVFETSCYLSLSEEKLLNDGFTMLLPACRGAELSMVLNFLQVVIARLRSVHKRVSQGLQPGNADSNAQLPLVAKEHHLAVASALWRNFFPYLKSQRMSQTPPSPQLADTAAGFALLALDIPSKALSDLQPQPVLSMMQLFGWDDMVWPHLVSRYLSHLIQNSALCEAFSTMGYTSYEALTVRSWFRCVLQMFIDQPSGTLAKTDAERTVGKAYMEQLTEMTRLIFKLKEVESILSKARVEEPVLKQDPKNALVQFIKAVGRTYSGLQTLPEKSAMVLKALEYLGDVLKYVKPYLKAKGPPEGLQLAYWIIGCLVKFWAPILATSKAQQLLFRIIDCLLLPHSVLQQDKELPGALLSAIQESLHLYLQGLSFICCQSQARGAYLNQLLGSIVQQYFGRFLPPSPTALGAGQHPMLTALCSSITVPQALRLRKTTLHVINEHYMQFKGSAPPPRLASVLAFILEVLQRTQASELCDVELVLPAVLKCMVLVNELQVKKISTVIVQYMVQGCQARSGGEHATQLTSVFRQFIQDYTAVYDHRVFSILETVAVLDQTLVTSLIPTLTQSLKDSEYKQGLGRNAAQREAYKRLLTHLSEAGQNEIQKLENEAG
What is the function of this protein?
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks.  The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication.  It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs.  Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination.  Within the complex, MMS22L acts by binding ssDNA.
What are the official names of this protein?
Protein MMS22-like, Methyl methanesulfonate-sensitivity protein 22-like.
What is the protein family that this protein belongs to?
Belongs to the MMS22 family. MMS22L subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
Protein: ADT_MYCTT
Sequence: MSNKQETKILGMPPFVVDFLMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKAGRLDRRYNGIIDCFRRTTADEGLMALWRGNTANVIRYFPTQALNFAFRDKFKAMFGYKKDKDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGARQFNGLIDVYRKTLASDGIAGLYRGFGPSVAGIVVYRGLYFGMYDSIKPVVLVGPLANNFLASFLLGWCVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSIDAFRQIIAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQILLFGKAFKGGSG
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:30611538).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (PubMed:30611538).
What are the official names of this protein?
ADP/ATP translocase, ADP/ATP carrier, TtAac.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TNAA_VIBCH
Sequence: MENFKHLPEPFRIRVIEPVKRTTREYREKAILNAGMNPFLLDSEDVFIDLLTDSGTGAITQEMQAAMFRGDEAYSGSRSYHALARAVKDIFGYEYTIPTHQGRGAEQIYIPVLIKKREKEKGLDRSKMVALSNYFFDTTQGHTQINCCVAKNVYTEEAFDTGVKADFKGNFDLEKLEQAILEAGPANVPYIVSTITCNSAGGQPVSIANLKAVYEIAQRYDIPVIMDSARFAENAYFIQQRERDYRNWSIEEITREAYKYADGLAMSAKKDAMVQMGGLLCFKDESFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMRQDWLAYRINQVEYLVNGLEAIGVICQQAGGHAAFVDAGKLLPHIPADQFPAHALACELYKVAGIRAVEIGSLLLGRDPATGKQHPCPAELLRLTIPRATYTQTHMDFIIEAFEKVKANARNVKGLEFTYEPPVLRHFTARLKEKA
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: SEY1_AJECG
Sequence: MVANGHFAGSADGQDSSSYEHGVQVIDEDKEFNPNVSKYLTYENVTPAGFNYHLISVFGSQSTGKSTLLNNLFGTHFSVMSETERRQTTKGIWLSKNKRLELRKDRDPQAKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLELFLKDNKSTPRSLLFFVIRDFLGTTPLQNLQNTLLQDLNRIWSSLSKPAGLENSTINDYFDFAFAGLPHKNFQPDKFMDEVQKLSTRFCEGHRDPSSLDRKGTGSIEGGIFLPEYHRRIPADGFAVYAEGVWDQIVNNKDLDLPTQQELLAQFRCDEISREALVAFDEAISPFESKQAEAVQAGTPEVLGGLGPAMRNARMKAVKNFDTEACRYHKRVYQMKKTELQDKIDTRLKALFLGQLNAAHRSGVQEFSESVSAAVKAGQKKGASYDFAEIVRRQRKLAIEKFEKEARSTLVEDAPWSNYQQELSLYQKDLERTSGQLRRDEMRRLATRVERWVRSRLGESVDLEFNALGSGRGGSGAPEFGDKPSEKTIWDRVWTLFVDTVLDAERRFTERASSFDAGLDEVDVGLWRLRRKSWGVLRAKIDEEMMEGNLLLKLRENFEDKFRYDDAGVPRIWRPTDDIESVYSQARESTLTLIPLLARFKLAETNAPPPLDKWIGHTPSSATPADEEDLTPIGGVDDDEGKSLEEEMTLIGEAKKQDLTVRFKKTADGVYVEAKRSAIGGITQVPLYFYGLLFALGWNEILAVLRNPVYFLLLFVCAIGAYITYQLNLWGPIIKMTEAASHQAVEEGKRRLREFLEASDTGRQAMAMSGARNATEEHEMSRLSRKPAERGGRKNRADEDVDDDDDDF
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: TYR1_YEAST
Sequence: MVSEDKIEQWKATKVIGIIGLGDMGLLYANKFTDAGWGVICCDREEYYDELKEKYASAKFELVKNGHLVSRQSDYIIYSVEASNISKIVATYGPSSKVGTIVGGQTSCKLPEIEAFEKYLPKDCDIITVHSLHGPKVNTEGQPLVIINHRSQYPESFEFVNSVMACLKSKQVYLTYEEHDKITADTQAVTHAAFLSMGSAWAKIKIYPWTLGVNKWYGGLENVKVNISLRIYSNKWHVYAGLAITNPSAHQQILQYATSATELFSLMIDNKEQELTDRLLKAKQFVFGKHTGLLLLDDTILEKYSLSKSSIGNSNNCKPVPNSHLSLLAIVDSWFQLGIDPYDHMICSTPLFRIFLGVSEYLFLKPGLLEQTIDAAIHDKSFIKDDLEFVISAREWSSVVSFANFDIYKKQFQSVQKFFEPMLPEANLIGNEMIKTILSHSSDRSAAEKRNT
What are the official names of this protein?
Prephenate dehydrogenase [NADP(+)], PRDH.
What is the protein family that this protein belongs to?
Belongs to the prephenate/arogenate dehydrogenase family.
Protein: OBG_HERAR
Sequence: MKFIDEAKIEVIAGDGGNGVASFCREKFRPFGGPDGGDGGKGGSIWAVADRNINTLVDFRYSKMHKARDGENGRGADCYGKGADDIKLRMPVGTLIIDNNDGELIADLTEHGQEVLIAKGGEGGWGNIHFKSSTNRAPRQKSEGKEGERRELRLELKVLADIGLLGMPNAGKSTFISAVSNARPKIADYPFTTLHPNLGVVRVSHEKSFVIADIPGLIEGASDGAGLGIQFLRHLQRTRLLLHIVDLAPFDNVDPVKEAKAIVKELKKYDESLFDKPRWLVLNKLDMVPEEERKKRVKDFIKRFGWKGPVFEISALTHEGCSELVTEIYDYIAVQRQAEQRSEETPQMVEAARGIDSIDPDDPRFKIID
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_BURP6
Sequence: MARMIHCAKLGKEAEGLDFPPLPGELGKRLYESVSKQAWQDWLKQQTMLINENRLNMADPRARQYLMKQTEKYFFGEGADQASGYVPPAQG
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: C_BPCHP
Sequence: MHMFYYSIYDRKARSYGDLISFPSGEKEAAIRWFRDVVMDSDSKNILHRYPEDFDFCYIGYFDKDKGRFYPVDAGIVTIINAGEFFLDSEYRQEEV
What is the function of this protein?
Plays a central role in the packaging of viral DNA into phage procapsid, which occurs in the late stage of infection.  Can interact with the replicative complex after the completion of one round of DNA synthesis.  When protein ORF5 is bound to the replicative form, the complex becomes accessible to procapsid and serves as a DNA packaging apparatus (By similarity).
What are the official names of this protein?
Protein ORF5.
What is the protein family that this protein belongs to?
Belongs to the microviridae C protein family.
Protein: SRP19_METMP
Sequence: MKEIILWPAYIDLKRTKNEGRKVPKEIAIQNPKLKEIASKIKKMGLEYSVENKKSYPKESWEICGYIKVKVDESTSKLQFLKEICINMK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAA35_PONAB
Sequence: MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV
What is the function of this protein?
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.  Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity).
What are the official names of this protein?
N-alpha-acetyltransferase 35, NatC auxiliary subunit, Protein MAK10 homolog.
What is the protein family that this protein belongs to?
Belongs to the MAK10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSC4_YEAST
Sequence: MVVKKRKLATEAGGSDERPKYLPGKHPKNQEKTPHVDYNAPLNPKSELFLDDWHIPKFNRFISFTLDVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIKSRDYEYEDGPSNFLLDVELLTKNCQAYNEYDSLIVKNSMQVVMLIEFEVLKAKNLKRNYLINSEVKAKLLHYLNKLVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIVHSPMALSIVKQNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLTNYFNYLIQKEFFPELQDLNERGEINLEFDKFEFENYLAIGGGGPAAAGALAISALDNDIEPESNREDLIDQADYDFNHFEGLGNGYNRSLLTEDYLLNPNNFKKLIAKPETVQSEVKNERSTTSDIEKTNSLESEHLKIPKYNVIKSMQKEMQSLSEQHTMEYKPYKLIQQIYIFSSKNLYSQATKPLLGSRPSCNQNWVEYIFNGNELSQNENAFSFMLQPMQTFLTLQSHLTSSLKDTETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDNDKRNNITEIFDIRLSEGLNHLMFRCEDKISHETEFMNFWINVLP
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
What are the official names of this protein?
Chromatin structure-remodeling complex subunit RSC4, RSC complex subunit RSC4, Remodel the structure of chromatin complex subunit 4.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Protein: ACH4_DROME
Sequence: MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNFMLPPDIVRQVLT
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit beta-like 2, Nicotinic acetylcholine receptor beta 2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NU4LM_EUBJA
Sequence: MTLIHMNIIMAFSMSLVGLLMYRSHLMSALLCLEGMMLSLFVLAALTILNSHFTLANMMPIILLVFAACEAAIGLALLVTISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.