PharMolix/UniProtQA huggingface dataset:
Protein: DBP7_CRYNB
Sequence: MADDIELNFAVPASGLVRQVAPKKGGRWTDRVRAKREARDAFKSMKANHLTVQNPSMPTVSASELVPKPAVIKPAPTSASVSRHPQPKSQVVAPPRFTNATAGPSRPAPSPQAASSNVPKSASIPAPATIKHRTSLPTNAFERPPLPPQAGPSRPHPAEKLKTPQFISSLFTSAPLPGVKSSVAPEISTGAPSNAPVDTTTFQGLGLNKLLINHLKGKMGVEKPTGIQRNCLPYMLSSPLNPDKKAGDEGPKEEPLRDVLIQAQTGSGKTLSYLLPIVQTLLPLSRLSYIDRSIGTLAIILAPTRELAQQISKVLEQLLHMSFAASKEGSDDEDEDDRPFTRWLVSGLLTGGSTRTHEKAKLRKGVPILVSTPGRLLDHLQNTMSFQCAKTMFLVLDEADRLMDLGFEETIQGIIKALEGRRRNEINIEKEMDKEGGGTMRWPFWDRGRLNVLCSATVDAKVERLAGAALRDPVLFRSEKDEAEAKKKAEGKDDAVIKALNEAQAIVIPQESEEKFTPPSQLSQKYVVLPTKLRLVALVALLRSLISSVAKGISVSNGTKVIVFLSSTDAVDFHWKLLGGVQMGQQGQQADGEKEEDEEEEGESVEERESDGESKAKKSKRKAKSKSTDDIVSLASPLFPNTTLHRLHGSLPLRTRLASLKAFATSSSQPSVLFATSVASRGLDLPLVRAVVQYDLPTEGGANEYVHRVGRTARAGKGGEAWAFVSPSEEGWVKWIEGKMGAAEGKSGVNLGQVGVEDVLRKGFGGKSYEYEARATDVQLSFENWVLASEQNAALARKAFASFVRAYSTHPLEEKQFFHTKLLHLGHLAKSFALREAPAQLASALSAGKSKRPKSKAASSATHPGKRKRDEDEDEMEERGGKELTARNETERRMYEAVRKQGRTIKSGGKLGEFSGKGQNKGQKAAATGGEFHIVNTGELERLVARRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SUCC_CLAM3
Sequence: MDLFEYQARDLFESYGVPVLPGIVADTAEEVRAAAEKLGGTVVVKAQVKTGGRGKAGGVKVAQSADAAFEAAEGILGLDIKGHTVHRVMVAAGARIAQEFYFSILLDRAERSYLCLASYEGGMEIEELAVTRPEALARIEIDPVAGIDAAKAEEIARAASFPEELIAKVAPVFERLWWVYRDEDATLVEVNPLVLTESGEIIALDGKVTLDENAGLRHEGHAALEDAAAADPLEAKAKESDLNYVKLDGQVGIIGNGAGLVMSTLDVVSYAGEQHGGVRPANFLDIGGGASAEVMAAGLDVILGDEQVTSVFVNVFGGITSCDAVANGIVGALDKLGDAATKPLVVRLDGNNVEEGRRILEERAHPLVTVVGTMDEAADKAAELAAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: HACD4_XENLA
Sequence: MKTYLSIYYLIQFCGHSWIFTNMTTRFLFFGQDAFADTFYSIGLVMQGCQLLSILELAHILLGVEQNGFLPMFLQVAERFIILFVVITSQEEVQSKYIVCALFFIWNLWDVIRYPYDMLAAVDTDYSALTWLRHTWWIVAYPLSVLAEAYTIYESLPYFESLGTYSFKMALPVSLSFHFPYILTLYLVLQPVGMLYICSCLWSERKQYFQRKLKLKKN
What is the function of this protein?
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle.  This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation.  Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase, 3-hydroxyacyl-CoA dehydratase, HACD, Protein-tyrosine phosphatase-like A domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the very long-chain fatty acids dehydratase HACD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NANK_ECOBW
Sequence: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEFQALDGDITDMVFITVSTGVGGGVVSGCKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADAKTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: MUTS_ACTSZ
Sequence: MPNFDAHTPMMKQYLTIKAENPDILLFYRMGDFYEMFYDDAKKAAALLDISLTKRGQSAGRPIPMAGVPYHAVEGYLAKLVQLGESVAICEQIGDPAASKGPVERKIVRIVTPGTVSDENLLPERQDNLLVAVYQEKDRFGLASLDMSSGRFQIAEAENAETLHAELQRLQPAELLYSEDFSEMAIIEQTKGLRRRPIWEFELGTAVQLLNRQFGTKDLKAFGVEKAVLGLCAAGCLFQYAKETQRTALPHIKSISLVQNSDTVQLDAATRRNLELTRNLSGGTENTLASVLDKCVTPMGSRLLKRWIHQPIRKIQKLRQRQQTIAAILQDDLIDELQPLLRQVGDMERILARVALRTARPRDLTRLRTALEQLPQLQQIIKTLQNLTALSQPMGEFAELCDLLQRAIIDSPPLLIRDGGVIAPGYHAELDEWRSLADGATQYLADLERRERESTGIDTLKIGYNAVHGYYIQISQGQAHNAPMHYVRRQTLKNAERYIIPELKTYEDKVLKAKGAALALEKQLYEEIFDQLLPHLAALQLSSMTLAELDVLTNLAERAETLNYVCPEFSPEIGVEIQNGRHPVVEQVLKEPFIANPVCLNPQRRLLVITGPNMGGKSTYMRQTALITLMAYMGGFVPAERAVIGPIDRIFTRIGASDDLASGRSTFMVEMTEMANILHQATADSLVLIDEIGRGTSTYDGLSLAWACAEWLAKKLRSLTLFATHYFELTVLPEQFAGTANVHLDALEHDNTIAFMHAVQDGAASKSYGLAVAALAGVPQQVIKLAKQKLAQLEKLSAQSADQKLQDLRTLHQMQGELALMEEDDGKNAALEMLEKLDPDELSPKQALAYLYQLKTLL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AROA_SHEON
Sequence: MKQLRLEPVVQVRGEINIPGSKSISNRALLLATLAQGTTTLTNLLDSDDIRHMLASLKQLGVEYRLSHNNTVCELAGLGGVMSSKQAQTLFLGNAGTAMRPLCAALTLGQGEFTLTGEPRMEERPIGDLVDALRQLGANIVYLKNDGFPPLTINATGLNGGDVEIVGDLSSQFLTALLMVAPLAKGSVNIHVKGELVSKPYIDITLALMAQFGVKVINHHYARFEIPAGQHYVSPGKVLVEGDASSASYFLAAGAIKGGEVKVTGVGRLSIQGDVKFADVLEKMGADIEWGDDYIIARGAPLTAVDLDMNHIPDAAMTIATAALFAKGTTVIRNIYNWRIKETDRLAAMATELRKVGAEVEEGNDYIKITPPAVLNTAQIDTYNDHRMAMCFSMLAFADCGITINDPDCTSKTFPDYFVQFASLKV
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A18_CAMPS
Sequence: MSLLKMEYNLYTELKKMTCGQSLSLFNEDGDFVEVEPGSSFKFLIPKGFYSSPSVKTSLVFETLTTTDNKITSINPTNAPKLYPIQCKVVSEVVSNMRKMIELKRPLYITLHLACGFGKTITTCYLMAIHGRKTVICVPNKMLIHQWKTQVEAVGLEHKISIDGVSILLKELKTQSPDVLIVVSRHLTNDAFCKYINKHYDLFILDESHTYNLMNNTAVTRFLAYYPPMMCYFLTATPRPSNRIYCNSIINIAKLSDLKKTIYVVDSFFEPYSTDNIRHMIKRLDGASNKYHIYTEKLLSVDEPRNQLILNTLVEEFKSGTINRILVITKLREHMVLFYKRLLNLFGPEVVFIGDAQNRRTPDMVKSIKELNRFIFVSTLFYSGTGLDIPSLDSLFICSAVINNMQIEQLLGRVCRETALLDRRVYVFPNTSIKEIKYMIGNFVQRIISLSVDKLGFKQESYRKHQESDPTSACTTSSREERVLNRIFNSQNR
What is the function of this protein?
DNA helicase which seems to act as a postreplicative transcription termination factor.  Involved in ATP-dependent release of nascent RNA.  Forms a stable complex with single-stranded DNA, and to a lesser extent RNA (By similarity).
What are the official names of this protein?
Transcript termination protein A18.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Poxviruses subfamily.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: VSPH3_BITRH
Sequence: VLIRVLANLLLLQLSYAQESSELVIGGDECDINEHPFLVALHTARSKRFHCAGTLLNKEWVLTAARCDMENMQIYLGLHNISRPNQDQKRRVPKEKHFCVSSKTYTRWDKDIMLIRLKRPVNDGTHIAPLSLPSNPPSVGSVCRIMGWGSITTTKVTYPDVPHCANIKLFDYSVCRDAYKGLPEKSRTLCAGILEGGIDSCKVDNGGPLICNGQFQGIGSWEGHPCAQPLKPALYTNVFEYTDWIEGIIARNTTVTCPP
What is the function of this protein?
Snake venom serine protease homolog that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease homolog rhinocerase 3, BG-RHIN3, Venom serine proteinase-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_SULIY
Sequence: MANGPNYKIKPRRRREGKTNYYKRYVYVISKQIRFIVRITNKYVIVQIAKIDPKGDIMVASAHSSELTKKFEWKGDENNTPSAYLTGYLAALRAVKKGVTECVADIGLHVPSKGNKVFYAIKGAIDAGLKIPIGDISIENDRIKGEHIAKYAEKLKSENLDLYNKLFSRYLGRGLNPENLPSHFEEILNKIKSSGG
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: METE_SALPB
Sequence: MTILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLLTTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLWVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: NU3C_TRIV2
Sequence: MFVLSGYEYLLGFLIICSLVPALALSASKLLRPTGNSLERRTTYESGMEPIGGAWIQFNIRYYMFALVFVVFDVETVFLYPWAVAFHRLGLLAFIEALIFIAILVVALVYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: YCR2_BACTK
Sequence: MLKYHFPNVCEDELINIYSYGDFKGQGKYICLFKIENQSFLFWRNDKGNKIYTNLESISVEIINTNNTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVYTQDLIDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLVDTYNQSQNVCPQDLNVYTQDLIDTYNQSQNCDCGCK
What is the function of this protein?
A protein probably derived from this gene is found in cuboidal crystalline inclusions, but is not toxic even when coexpressed with upstream ORF1.  The protein runs anomalously as a 50 kDa band in gels.
What are the official names of this protein?
Uncharacterized 29.1 kDa protein in cryB1 5'region, ORF2.
Protein: CAPSD_CVB
Sequence: MPPKPAPGDNEGNASGSTPTPPPPPPARTAEEARLRLAEMEREREQEQLLEEMNSNTPAEDARNISRLTQLAALLRREQTNVHVTNMALEIGRPALQPPPNMRGDPTNMYSQVSSDFLWKIKPQRISNNMATSEDMVKIQVALEGLGVPTESVKEVIIRLVLNCANTSSSVYQDPKGVIEWDGGAIIADDVVGVITKHSTLRKVCRLYAAVAWNYMHLQQTPPSDWSAMGFHPNVKYAAFDFFDYVENGAAIRPSGGIVPKPTRAEYVAYNTYKMLALNKANNNDTFGNFDSAITGGRQGPAIHNNLNNANNKTL
What is the function of this protein?
Required for genome encapsidation.  Forms ribonucleoprotein complexes along with TGB1 helicase and viral RNA.
What are the official names of this protein?
Capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the potexviruses coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: SYK_LIMF3
Sequence: MANEEHLNDQMVVRREKMQALRDQGVAPFGHRFDPDHDLSTDIRKKYENDSGELLLAQHNVVTIAGRMIGKRGSGKASFADLLDRGGKIQFYVRQDMVGEEAYKLFKESDLGDFWGITGDVIKTRMGELTVRAEKITFLSKALRPLPDKYHGLQDPELVYRQRYLDLITNRESFERFQTRTKIIKAVRRYMDDNGFLEVETPILENIASGAEARPFVTHHNALNIDMYMRIATELRLKRLIVGGMERVYELGRIFRNEGMDPYHNPEFDTMETYAAYFDFNDVMKETEGIFKAAAGVVADDLKITYQGTELDFSTSFKRLHMVDAIKEATGIDFWQEMTVEEARKLADDNGIKYESWWKVGHIINAFFEEKVQDTLEQPIFIYGHPVEVSPLAKINEEDSRFTDRFELYILGKEYANAFSELNDPIDQRKRFEAQAQENAEGNDEAQPIDEDFVEALEYGMPPTGGLGVGIDRMVMLMTDAKSIRDVLLFPTMRPKK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSDHL_HUMAN
Sequence: MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity).  Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity).
What are the official names of this protein?
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating, Protein H105e3.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Lipid droplet. Note=Trafficking through the Golgi is necessary for ER membrane localization.
Protein: RL6_RICB8
Sequence: MSCVGKLPIIIPEGVKVGLNDLEVKISGPKGELSKSFKGSIGISLAENKLLVKPLSSSKSARAMWGTARSIISNMVTGVKEGFKLKLEINGVGYRAMMKGKYLNLMLAKSHNTKIEIPSHIKVEVPKQNIIILEGTDKEKLGQFASIIIKQRPPEPYKGKGIKFEDQFIPCKEGKKN
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DEOD_ECO45
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDKE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PSBZ_NOSP7
Sequence: MTIIFQFALIGLVLLSFVLVVGVPVAYATPQNWVESKKLLWVGSAVWIALVFLVGLLNFFVV
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: ISPH_FRAT1
Sequence: MKILLANPRGFCAGVSRAVETVEKVLEVEKSPVYVRHEVVHNKVVVDSLKKKGVVFVKEVDEVPDDAVCIFSAHGVSLKVEEAAAKKNLVLYDATCPLVTKVHRGVRLASNNDAECILIGHKGHPEVQGTMGQYRSKKGAIYLIESEEDLNKLTIKDPDNLYYATQTTLSVDETQGIIQALKDKYPNIKGPKKEDICYATQNRQTAIKAMLKHIDVLVVVGSQNSSNSNRLKELATLEGIDAYLVDNPKDVDKLWFDNKKVCGVSAGASAPEYLVQQIISQISKVCSTEVEEFEGIKEEVYFPLPRLLKQKIGTGKVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: SSRP_YERPP
Sequence: MTKKKAYKPGSATIAQNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVMFKNGEAFLFGATITPLNVASTHVVCEPMRTRKLLLNKRELDSLFGRVNREGYTVVALSMYWKNAWVKVKIGVAKGKKDNDKRDDIRDREWKLDKARIMKHANR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PG082_VACCW
Sequence: MNNFVKQVASKSLKPTKKLSPSDEVISLNECIISFNLDNFYYCNDGLFTKPINTPEDVLKSLLIMESFAYEKMIIKGLIKILISRAYINDIYFTPFGWLTGVDDDPETHVVIKIIFNSSLISIKSQVIEYLKPYNVNNLSVLTTEKELSINTFNVPDSIPMSIISFFPFDTDFILVILFFGVYNDSYCGISYISPKERLPYIIEILKPLVSEINMLSDEIGRTSSIRIFNSTSVKKFPTNTLTSICEIVYSFDESSFPTPKTFTPLNASPYIPKKIVSLLDLPSNVEIKAISRGGVDFITHINNKRLNTILVIAKDNFLKNSTFSGTFIKENIIWKGIYTYRIIKSSFPVPTIKSVTNKKKICKKHCFVNSQYTTRTLSHIL
What is the function of this protein?
Binds to the hairpin form of the viral telomeric sequence.  Might direct genome encapsidation into the virus particle.
What are the official names of this protein?
Telomere-binding protein OPG082, Telomere-binding protein I6.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG082 family.
Protein: SFRP1_MOUSE
Sequence: MGVGRSARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNTTEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKRMKNHECPTFQSVFK
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types.  SFRP1 decreases intracellular beta-catenin levels (By similarity).  Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response.  In vascular cell cycle, delays the G1 phase and entry into the S phase.  In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity).  Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity).
What are the official names of this protein?
Secreted frizzled-related protein 1, sFRP-1.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity).
Protein: NUOC_MYCSJ
Sequence: MTEANGTTGGGAGDPEVIDVRRGMFGAKGSGDTSGYGRLIRSVALPGGSPRPYGGHFDEVVDALAAALGQDLYDASVERIVVYRDELTLEIARARLPVVAKTLRDDAALRFELCLGVSGVHYPGDAGRELHAAYPLMSITHNRRIRLEVAAPDDDPHIPSLFSVYPTTDWHERETYDFFGIIFDGHPSLTRIEMPDDWVGHPQRKDYPLGGIPVEYHGARIPPPDERRAYN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL18_CHLT3
Sequence: MSSKSKFVRRQRIKRRVRSVVSGTEQRPRLTVFRSLSHIYAQLIDDVNGHTLVAASSMPSKGASLLKGKKSDVSREVGKALAEKAKAKGIDAVVFDRNGYRYHGRVKALAEGAREGGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TRP5_RHYMA
Sequence: APAMGFQGVR
What is the function of this protein?
Myoactive peptide.  Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
What are the official names of this protein?
Tachykinin-related peptide 5, LemTRP 5.
What are the subcellular locations of this protein?
Secreted.
Protein: BGAM_LATSK
Sequence: MANTNKRLAVIFGDVTLGLKGPDFHYLFSYQTGGPESLRIQGKEWLYRSPKPTFWRATTDNDRGNQFPLKSGMWLAADQFIACQSITVAIDGQTIPLPIAPENNRYSGRETAQEVTVTYTYQTITTPQTTVEVSYTIQASGKIRVAVTYHGQAGLPSLPVFGLRFVMPTPATRFIYQGLSGETYPDRMAGGIAGEYEVTGLPVTPYLVPQDCGVHMATDWVTIYRQAVLDNCLHEPVETGLKFKMVDQPFAFSCLPYTAEELENATHHSELPAPHRTVLNLLGAVRGVGGIDSWGSDVEVAYQIDATQDRHFEFEISF
What are the official names of this protein?
Beta-galactosidase small subunit, Beta-gal small subunit, Lactase small subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial beta-galactosidase small subunit family.