Protein: BEA1_BEABA
Sequence: MEPLKNVNTGQPCSTVPFPVSDETVEHLNGLYEEINRRFGLDRDAIETILPCTPFQYDVLDCAANDARHAVGHAMYEISQHVHVQRFIAAWRETVRRTPALRACTFTSTTGESFQLVLRESFVLSRIYWSSSSSLQAAVLKDETTAAIAGPRCNRLVLLEDPDTRKQLLIWVFHLALVDSTVQEPILRRVLAAYKSEDDQLDSLPLTPDSSGGSDSDSPSTLKMPRAFDQEKATQFWQRQLSGLDASVFPPLSSHLTTPKADAKIEHYISWPASAAQHRWSSTTVCQAALAVLLSRYSHSSEALFGVVTEQVCMFEGQRLLINGPTRSVVPFRVHCGPEQSVTDLLKSIASDNHDMRQFAHVGLCNISRIGDDQSAACRFQTVLSVSNRRSSEDAASGEVLQILQESEGFAPCADRALLLRCETSRQGALLVARYDQGVIEPPQMARFLRQLGWLMEQLQSAADDALSVKQLDIVTREDRAEIDSWNSDALEVQESLLHSAFVKRAAESPSDPAVLSWDGAWTYSELDNVSSRLAAHIRSLDLSHEQLIVPVYFEKSKWVVASILAVLKAGHAFTLIDPKDPPARTTRIVQQTSAKVALTSKLHQDTVQAIIGRCIVVDDDFVQSLGSASQCQEKSELTVKPHNLAYAIFTSGSTGDPKGIMIEHQAFASCVAKFGPALIPHNARALQFASHGFGACLLEILPTLLRGGCVCIPSDLDRMHNIPDFIRRYNVNWMMATPSYMTTFKPEDVPGLQTLILVGEQMSASVNATWASRLGLFDGYGQSESCSICFIGKISPVSEANNIGRAVGAHSWIVHPDDPDRLAPVGAVGELLIESPGIARGYIAAPATDRNPFLETAPAWYAPRQPPTGVKFYRTGDLARYAADGTVVCLGRIDSQVKIRGQRVEMGAVETRLRQQVPSDITVVAEAVKRSGSSGSTVITAFLIDSSDKNNSSAASAKDARILDQTATQEMNAKLCQVLPPHSVPSCYICMHALPRTATGKVDRKTLRSIGSKLLEQQAYKKSPETMQKSKSAETLETGPEARLKEVWLQSFNLEPASPKCGASFFELGGDSITAIKMVNMARAAGLELKVSDIFQNPTLARLQAVMSGDSTPSTITTPFATIPASTWDGPVEQSYSQGRLWFLDQLDIGAVWYLIPYAVRMRGALNIDALRAALLALEQRHETLRTTFENQNGVGVQIVHQRLAKELKIIDASSHGDDGYLQPLEQEQTTPFDLTCEAGWRASLICVGEDHHVLSIVMHHIVSDGWSIDVLRQELGQLYAAVLHGDEDPLSAVSPLPIQYRDFSMWQRRQQVAEHDRQLQYWRKQLADCSPAKLPTDFPRPPLLSGDAGSVPVEISGELFQKLHRFCNVTSTTPFAVLLAAFRAAHYRLTGVDDAVVGTPIANRNRPELERLIGFFVNTQCMRITVDDDDTFEGLVRQVRRTTTEAFENEDVPFERVVSAMLPAGGGSRDLSQTPLAQLIFAVHSQENLGKFELEGLESEPVANKAYTRFDAEFHLFQTRDGLNGYLNFAAELFKLETMQNVVSVFLQILRHGLEQPKSLISVLPLTDGLKELDSMGLLKIHRGLEYQRDSSLVDIFRSQVATCPDTIAVIDSSARLTYAQLDHQSNLLEAWIRRKGLPAESLVGVLSPRSCETIIAFLGILKANLAYLPLDPKSPVSRMRDVLSDLPGHTIILLGSDVAAPDLELPCLELVRISDALKSGASAVNGSETTDLSAPSANSLAYVLYTSGSTGRPKGVMVEHRAIVRLVQRGVIPNFPPLRGAIMAHLFNTVFDGATYEIFLMLLNGGTLVCIDYLTTLSPKALETVFLREGINCAIMTPALLKLYLANARDGLKGLDMLMVAGDRFDPQDAVEAQTLVRGDCYNAYGPTENGVMSTLYKIDTSDSFINGVPLGRAIDNSGAYITDPNQQLVGPGVLGELIVTGDGLARGYTDPALDRDRFVQVVINGESVRAYRTGDRMRYRAGQDCLFEFFGRMDFQFKIRSNRIESAEVEAAILSHPLVRDAAIVVVGVQEEQEPEMVGFVVAADDAVEQEATDNQVEGWQELFESSMYNGIDAISPSALGKDFTGWTSMYDGSEIDKSEMQEWLDDTIHTLRDGHVPGHVLEIGTGTGMILFNLGSVESYVGLEPTKSAVEFVNKAIKTLPNLAGRAEVHTGTATDIDQLSGLRPDLVILNSVVQYFPTVEYLTRVVDALVRIRGVKRLFFGDVRSQALHRQFLAACAMHALGKTATRDDVRRYMAEREEREEELLVEPAFFTALMNRHPNLIQHVEILPKNIRATNELSAYRYAAVVHLRDPESAARPVYPIAADDWVDFQASQMRSDVLREYLRLSAGADTVAVCNIPYEKTIFERLIVESLDDNTGSDAPQSRLHGRSLDGAPWISAVRSDAESRASLSVPDLVQLAAESGFQVQVSAARQWSQSGALDAVFHRRHASSSQPTMRTLFQFPDDNALRASATLTNRPLQRLQRRRVAAQIRERLQTLVPSYMIPAKIVVLDQMPLNANGKVDRKELARRARTTTMTKKKKPQRLASEPACPISDIEVALCEEATATFGMQVGISDHFFKLGGHSLLATKLISRVGDRLKARLTVKDVFDHPIFSELAIVIREGLQNVVPVALNGGGQAKQGSAGVVAPRNEMETMLCEEFANVLGMDVGVTDNFFDLGGHSLMATKLAARIGRRLNTTISVKEVFEHPIVFQLANSLELGQLESDRVKHTMLADYTAFQLLSVEDLQGFLQNEISPQLECAHGGIQDVYPATHMQKAFLCDASTGHPKPLVPFYIDFPPDSDCSTLVEACSSLVKRFDMFRTVVVEAAGELYQVVLEHFDLQIDVVETEENVHAATNDFVDRILEVPVHLGQPLIQFTILKQASSVRVLLCLSHALYDGLSLEHVVRDLHMLYKGRSLLPANQFSRYMQYMDHTRKAGCDFWRDVIQDTPITVLGHVDAGGRELEVEAARTLHATKIISIPLQAVRSSIITQATVFNAACALVLSRETGAKDVVFGRIVSGRQGLPVSWQNIVGPCTNAVPVRARIIDDDDDNHRQMLRDMQDQYLLSLPFETLDFDEVRRSCTNWPATANNYACCVTYHDFSYHPESEMEQQRVEMGVLARKDALLKEEPVYDLGIAGEVEPDGVHLQVTVVAKTRLFSEERAAYLMEEVCRLFESLNSAL
What is the function of this protein?
Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:18804027, PubMed:28534477).  Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (PubMed:19105175, PubMed:27449895).  The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (PubMed:18804027, PubMed:28534477).
What are the official names of this protein?
Beauvericin nonribosomal cyclodepsipeptide synthetase, BEAS.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.