PharMolix/UniProtQA huggingface dataset:
Protein: NEF_HV1MN
Sequence: MGGKWSKRVTGWPTVRERMRRAEPAELAADGVGAASRDLEKHGALTSSNTAATNADCAWLEAQEEEEVGFPVKPQVPLRPMTYKAALDLSHFLKEKGGLDGLIYSQKRQDILDLWVYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKIEEANKGENNCLLHPMSQHGMDDPEREVLVWKSDSHLAFQHYARELHPEYYKNC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: DAW1_XENLA
Sequence: MRLKRFLLRYFPPGIILEYEKGGELKTKAIDLLELSPTTDVDLVVGEIQKAEPLITASRTQQVKQLILRLQEKIGQQDSRQFYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLVFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRIHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHDDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRIVTASSDKTSRLWDPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIWR
What is the function of this protein?
May play a role in axonemal outer row dynein assembly.
What are the official names of this protein?
Dynein assembly factor with WDR repeat domains 1, Outer row dynein assembly protein 16 homolog, WD repeat-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR69 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: CH10_BACCN
Sequence: MLKPLGDRVVIELVQAEEKTASGIVLPDTAKEKPQEGKVIAVGTGRVLENGERVALEVAAGDRIIFSKYAGTEVKYEGTDYLILRESDILAVIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_STRT1
Sequence: MAIADGKVSLKHLVTMETLTNEEVLGMIRRGGDFKNGRADFQLDRQYFAANLFFENSTRTHKSFEVAEKKLGLDVIEFDAGTSSVNKGETLYDTILTMSALGVDICVVRHSEVDYYKQLIDSRTIQTSIVNGGDGSGQHPSQCLLDLMTIYEEFGTFGNLKICIAGDITHSRVAKSNMRILKRLGAQIYFAGPTEWYSSEFDVYGQHVAIDDVIEDLNVLMLLRVQHERHRNDKGFSKEEYHTLYGLTEERYAKLADQAIIMHPAPVNRDVEIADSLVEAPKARIVTQMQNGVFVRMAIIEAILNGKA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: UVRC_ECO81
Sequence: MSDQFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVEGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLISRMETASQNLEFEEAARIRDQIQAVRRVTEKQFVSNTGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELSEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRKINVQTKPRGDRARYLKLARTNAATALTSKLSQQSTVHQRLTALASVLKLPEVKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNITGITPGDDYAAMNQVLRRRYGKAIDDSKIPDVILIDGGKGQLAQAKNVFAELDVSWDKNHPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSSLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKBP_DEBHA
Sequence: MSAPATTQVEILQEGDGKTFPKPGDLVTIHYTGTLENGKKFDSSRDRGKPFQCTIGVGQVIVGWDTGIPKLSVGSRAKLSIPGHEAYGDRGFPGLIPPNATLLFDVELLNVN
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 1, FKBP, Peptidyl-prolyl cis-trans isomerase, PPIase, Rapamycin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_STAAS
Sequence: MTKGILGRKIGMTQVFGENGELIPVTVVEAKENVVLQKKTVEVDGYNAIQVGFEDKKAYKKDAKSNKYANKPAEGHAKKADAAPKRFIREFRNVDVDAYEVGQEVSVDTFVAGDVIDVTGVSKGKGFQGAIKRHGQSRGPMSHGSHFHRAPGSVGMASDASRVFKGQKMPGRMGGNTVTVQNLEVVQVDTENKVILVKGNVPGPKKGLVEIRTSIKKGNK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CH10_LEGPL
Sequence: MKIRPLHDRVVVRRMEEERTTAGGIVIPDSATEKPMRGEIIAVGAGKVLENGDVRALAVKVGDVVLFGKYSGTEVKVDGKELVVMREDDIMGVIEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_PSEU2
Sequence: MDFFYIGVMSGSSLDGIDIALLKQDDRSRLLATHYIPMPEDLHAELLGLCSSGADELARAAIAEQKWCRLVAQGVQTLLQDQNMVPAQIRAIGSHGQTIRHEPSRGYSIQIGNPALLAELTEITVVSDFRRRDIAAGGQGAPLVPAFHEALFDDNKDHRAVLNIGGFSNLSLIESDRPVEGFDCGPGNVLLDAWISSQLHESYDKDGAWSASGKVDSALLQKLLSDQFFLTKGPKSTGREVFNLGWVKHHLFQSKTLAPEDVQATLLELTALTITDSLKSAQPITRELLVCGGGAHNKALMKRLAELLPDTEVSSTEKFGVNPDWVEAMAFAWLAHCCLEGVPANRPTVTGAKGRRVLGAIYPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PSBX_THEVB
Sequence: MTITPSLKGFFIGLLSGAVVLGLTFAVLIAISQIDKVQRSL
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.  PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: YDIH_ECOLI
Sequence: MSTQLDPTQLAIEFLRRDQSNLSPAQYLKRLKQLELEFADLLTLSSAELKEEIYFAWRLGVH
What are the official names of this protein?
Uncharacterized protein YdiH.
Protein: SYFB_METM6
Sequence: MPTININKVDLERLSNISLSDKMIEDRFPMMGVEVEEIFEEVDKNGKKQNMVQFSINPDRPDYLSVEGLARGFRGFMGINTGIQEFEVLNSNIKVTVEENKTRPYVAFALVKNVLMDELVLESMINLQEKLHWAIGRDRKKLAIGIHDFDKVKAPFTYKEIRGDEIKFVPLGYEDEEMTPREIIEKHEKGIKYAHLIQDDKFPVIVDLNGEVLSMPPIINGTLTKVTPTSKNLLIDITGTEKEAVEETLNIIVCALAERRGTIVSVDVNGKKYPDLTPKSRMISVESINKKLGLNLNPGEIIQAVKKSGMDALYEDGNLIVKIPAYRNDILHNVDLKEEIAINYGYEKFEGKLPSVATTGSKDSVEKKCSAMSDLMIGLGFYEVMNLTLSNQDTLFEKMNLEVEEKDYIEVLKPASIEHRVLRTSILPLLLETLYINKHHSLPQKIFEIGDCVIIDENDTETDTKCKNIKKIAGAITHPLTNFNEIKSSTGALLREFFEDFEFENYEHPAFIPGRCAKIIKDRKEVGFFGEIHPEVILNFELEHPIVGFEITIE
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACM5_MACMU
Sequence: MEGDSYHNATTVNGTPVYHQPLERHRLWEVISIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGVMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTEAEKRKPAHRALFRSCLRCPRPTLAQRERNQTSWSSSRRSASTSGKPSQATDPSTNQAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSRGKESPGEEFSSEDAEETFVKAQTEKHDSDTPNYFLSPAAAHRPKSQKCVAYKFRLVVKADGTQENNNGCHKVKIMPCSFPVAKEPSTKGLNPNPSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is Pi turnover.
What are the official names of this protein?
Muscarinic acetylcholine receptor M5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: PA2H2_BOTMT
Sequence: SLFELGKMILQETGKNPAQSYGAYGCNC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity (PubMed:24724078).  Shows high myotoxic activity, neutrophil activation (demonstrated by activation induction of IL-1beta production), and slight cytotoxicity against Jurkat (leukemia T) and SK-BR-3 (breast adenocarcinoma) tumor cell lines (PubMed:24724078).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog BmatTX-II, svPLA2 homolog, Lys49 PLA2-like.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HCAC_ECO57
Sequence: MNRIYACPVADVPEGEALRIDTSPVIALFNVGGEFYAINDRCSHGNASMSEGYLEDDATVECPLHAASFCLKTGKALCLPATDPLTTYPVHVEGGDIFIDLPEAQP
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.  This protein seems to be a 2Fe-2S ferredoxin (By similarity).
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: DCD_SHEAM
Sequence: MRLTDFEIEQALDAGTILIEPRPSNDAISGVSVDVRLGNQFRVFQDHTAPFIDLSGPSAEVQAALDRVMSDKIDIKDGNAFFLHPGELALAVTLESVTLPADIVGWLDGRSSLARLGLMVHVTAHRIDPGWQGKIVLEFYNSGKLPLALRPGMTIGALNFERLSGPVSRPYNKRKNAKYKDQQEAVASRISQDS
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RS16_STRPD
Sequence: MAVKIRLTRMGSKKKPFYRINVADSRAPRDGRFIETVGTYNPLVAENQITIKEDRVLEWLSKGAQPSDTVRNILSKAGVMAKFHDQKFSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: 3MGH_ANADF
Sequence: MKLAREFYARDTREVARDLLGKVLVHRDGGVRRAARIVETEAYHGPDDLASHARFGPTRRAGIMFGPAGVAYVYLIYGTSHCMNVVTGAEGFPSAVLLRAGEPVEGCLHSTRGPGNLCRALAIRREHDNGRDLAGDDLFVEDAPPPRERIVAARRVNVDYAGPWAERPWRFALEGNAFVSRAPGEWRAVRGRRR
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: ALG8_MOUSE
Sequence: MAASGSATAGGHWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYALSHIAKYFDQEMLNIHNLNYYSSRTLLFQRFSVILTDALFVYAVHECCKCIDGKRTGKDLTEKPKFILSVLLLWNFGLLIVDHIHFQYNGFLSGLLLLSIARLFQKRHIEGALLFAVLLHLKHIYLYVAPAYGVYLLRSYCFTASKPDGSVRWSSFSVVRVTSLGLIVFLVSALSLGPFLALNQLPQVFSRLFPFKRGLCHAYWAPNFWALYNALDKVLSVIGLKLKLLDPSQIPRASMTSGLVQQFQHTVLPSVSPLATLICTLIAILPSVFCLWFKPQGPRGFLRCLVLCALSSFMFGWHVHEKAILLAILPMSLLSVEKAGDATVFLILATTGHYSLFPLLFTAPELPIKILLMLLFTVYSISSLKTLFRKEKPLFNWMETVYLLGLGPLEVCCEFLLPFTSWKLKYPFIPLLLTSVYCAVGITYAWTRLYASVLTGSLVSKTKKH
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity).  Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (PubMed:28375157).
What are the official names of this protein?
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8 homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CSP_STROR
Sequence: MKNTEKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK
What is the function of this protein?
Acts as a pheromone, induces cells to develop competence for genetic transformation.
What are the official names of this protein?
Competence-stimulating peptide, CSP.
What is the protein family that this protein belongs to?
Belongs to the ComC family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACR4L_ARATH
Sequence: MRMFETRAREWILLVKLVLFTSIWQLASALGSMSSIAISYGEGGSVFCGLKSDGSHLVVCYGSNSAILYGTPGHLQFIGLTGGDGFMCGLLMLSHQPYCWGNSAFIQMGVPQPMTKGAEYLEVSAGDYHLCGLRKPIVGRRKNSNIISSSLVDCWGYNMTRNFVFDKQLHSLSAGSEFNCALSSKDKSVFCWGDENSSQVISLIPKEKKFQKIAAGGYHVCGILDGLESRVLCWGKSLEFEEEVTGTSTEEKILDLPPKEPLLAVVGGKFYACGIKRYDHSAVCWGFFVNRSTPAPTGIGFYDLAAGNYFTCGVLTGTSMSPVCWGLGFPASIPLAVSPGLCIDTPCPPGTHELSNQENSPCKFTGSHICLPCSTSCPPGMYQKSVCTERSDQVCVYNCSSCSSHDCSSNCSSSATSGGKEKGKFWSLQLPIATAEIGFALFLVAVVSITAALYIRYRLRNCRCSENDTRSSKDSAFTKDNGKIRPDLDELQKRRRARVFTYEELEKAADGFKEESIVGKGSFSCVYKGVLRDGTTVAVKRAIMSSDKQKNSNEFRTELDLLSRLNHAHLLSLLGYCEECGERLLVYEFMAHGSLHNHLHGKNKALKEQLDWVKRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEEHNARVADFGLSLLGPVDSGSPLAELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVLLLEILSGRKAIDMHYEEGNIVEWAVPLIKAGDINALLDPVLKHPSEIEALKRIVSVACKCVRMRGKDRPSMDKVTTALERALAQLMGNPSSEQPILPTEVVLGSSRMHKKSWRIGSKRSGSENTEFRGGSWITFPSVTSSQRRKSSASEGDVAEEEDEGRKQQEALRSLEEEIGPASPGQSLFLHHNF
What is the function of this protein?
Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal.  Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem.  Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells.  Involved in the regulation of cellular organization during the development of sepal margins and ovule integument outgrowth and promotes giant cell formation (PubMed:25315606).  Can phosphorylate ALE2.
What are the official names of this protein?
Serine/threonine-protein kinase-like protein ACR4, Protein CRINKLY 4, AtCR4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Also localized into protein export bodies. Internalization may be involved in degradation of ACR4 for its rapid turn-over. In the epidermis, mostly expressed in the lateral and basal planes of cells.
Protein: GRPE_BACC0
Sequence: MEERNEQVVEEVKEAQVEEAVTPENSEETVEEKSEAALLQEKVDELQAKLTETEGRTLRLQADFENYKRRVQMDKQAAEKYRAQSLVSDILPALDNFERAMQVEATDEQTKSLLQGMEMVHRQLLEALNKEGVEVIEAVGKQFDPNEHQAIMQVEDSEFESNAVVEEFQKGYKLKDRVIRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG200_VACCC
Sequence: MTANFSTHVFSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVFIDIRELVKNMPWDDVKDCTEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLEMLNYVDYNIIFRRMN
What is the function of this protein?
Contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.  Mechanistically, sterically hinders the direct contact between the kinase domains of IKBKB in the IKK complex containing IKBKB, CHUK/IKKA and NEMO.
What are the official names of this protein?
Protein OPG200, Protein B15.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG200 family.
Protein: PYRF_MYCVP
Sequence: MSGFGDRLAGATARRGPLCLGIDPHPELLRAWGLGTDAAGLAGFSDICVAAFAGFAVVKPQVAFFEAYGSAGYAVLERTIAALRESGVLVLADAKRGDIGSTMAAYASAWAGDSPLAADAVTASPYLGFGSLQPLLDTAREHDRGVFVLAATSNPEGASVQCAVAPGAIPGRTVAQAIVDAAAEVNAGAARGSVGVVVGATLSAPPDVSALNGPVLVPGVGAQGGRPEALAGLGGARRGQLLPAVSREVLRAGPDVAALRAAAERMRDAVAYLGENP
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: GLMK_PREBR
Sequence: MNEQSMKPYVIGLDLGGTNSVFGIV
What is the function of this protein?
The enzyme has great affinity for glucose and mannose.
What are the official names of this protein?
Glucomannokinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: CRAS_ACHAC
Sequence: MATFQAHFFAAVMCVGVLGLSKLCGADSCEYPDCVFTGLPRSSGVERYILLLNIIEVPDDIQQQCDILIQRAHNCTSQRTGCSRRVEESYDRRFYDGAYVMYLLDLGVYVCGHLSQLLDLKNCFTPKLQESVQSCINAAYNIQCLLDQYDQKNNCPPNTDDYFHTLVNNWLANNPYLGTGADRD
What are the official names of this protein?
Cysteine-rich atrial secretory protein.
What are the subcellular locations of this protein?
Secreted. Note=Stored in secretory granules of atrial granular cells and released into hemolymph after electrostimulation of the heart nerve.
Protein: ARGO_ECOL6
Sequence: MFSYYFQGLALGAAMILPLGPQNAFVMNQGIRRQYHIMIALLCAISDLVLICAGIFGGSALLMQSPWLLALVTWGGVAFLLWYGFGAFKTAMSSNIELASAEVLKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLDVEPKRWFALGTISASFLWFFGLAILAAWLAPRLRTAKSQRIINLVVGCVMWFIALQLARDGIAHAQALFS
What is the function of this protein?
Involved in the export of arginine.  Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
What are the official names of this protein?
Arginine exporter protein ArgO.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RADB_THEAC
Sequence: MDEISLQQGVRRIQTGVGCIDALLNGGLEGGIITEIFGEGGSGKTNICMIASCSAMSQGLKVIYIDSEGLSPERFLAVCRSDISMFKLFRVYSLDDQEVAIMKASKMADRDQKIGMIVLDSFSEFFRLEKSDDRQARIAEFQRQLSLLSSVAAKKNIPVLITNQIYQDIDNGTLLPFGGFLVDHAMKAILRIEKMPDGRRRITVTKHRSVREGVSAMFRITDDGVSCEG
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  May regulate the cleavage reactions of the branch-structured DNA.  Has a very weak ATPase activity that is not stimulated by DNA.  Binds DNA but does not promote DNA strands exchange (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RadB.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family. RadB subfamily.