PharMolix/UniProtQA huggingface dataset:
Protein: LEUC_YERPP
Sequence: MGTTSSQSKTLYQKLYDAHIVHEAPNETPLLYIDRHLVHEVTSPQAFDGLRAMGRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMRIEVNGTVGAGITAKDIVLAIIGKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNMAIEMGAKAGLVAPDDTTFAYLKGRQFAPTGEQWEQGVAYWRTLKSDADAQFDTIVTLDAADIAPQVTWGTNPGQVIAVNQIIPAPESFSDPVERASAEKALAYMDLRPGIKLTEVAIDKVFIGSCTNSRIEDLRAAAAIAQGRKVAKGVQAIVVPGSGPVKAQAEAEGLDKIFIAAGFEWRLPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVSGHFADVRELSATTH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MRAY_BORDL
Sequence: MFCFLGLRLLKYITFRTAYATIFAFLLALIFGPFIISRLKKLKLDQILRKDGPKRHLSEKMGIPTMGGVLIFFCVLVSLFFWIHFFNIYFLIVLFVMVSFACLGFTDDLLKIKRKNSDGLNPKFKIYGQILFSFISVVMLYYFGGEHVSILYFPFFKSLKLDLGILYIPFGMFVLISASNSFNLTDGLDGLAIGLSIVVIGALIIIAYLTSRVDFALYLNIPNVKGCEELVIFLGALLGGSFGFLWFNAYPAKIMMGDTGSLSIGAVLGMVALILKSEILFAILAGVFVVETLSVIIQVVVYKKTKKRVFKMAPLHHHFEELGWSEMQVVIRFWIIGLIFAILALSTIKIR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MT2C_ORYSJ
Sequence: MSCCGGNCGCGSGCQCGGGCGGCKMFPDVEATATTKTFVLAAPSNKASSGGMEMAVESGENGGCGCNTCKCGTSCSGCSCCSCN
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable).  Acts as reactive oxygen species (ROS) scavenger in the cytosol.  Possesses superoxide anion and hydroxyl radical scavenging activities in vitro (PubMed:15220467).  Plays a role during root development, lateral root initiation and seed embryo germination, possibly by regulating levels of cytokinin (PubMed:18258694).
What are the official names of this protein?
Metallothionein-like protein 2C, Class I metallothionein-like protein 2C, OsMT-I-2c, OsMT2b.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ANR66_HUMAN
Sequence: MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNTKGRRV
What are the official names of this protein?
Ankyrin repeat domain-containing protein 66.
Protein: PSB10_BOVIN
Sequence: MQKTVLEPQRGFSFENCERNAALQRALPGLRVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKICEKIHFIAPKIYCCGAGVAADAEMTTRMAASNMELHALSTGRECRVATVTRMLRQTLFRYQGYVGASLIVGGVDFTGPQLYSVHPHGSYSRLPFTALGSGQDAAIAVLEDRFQPNMTLEAAQELLVEAITAGILGDLGSGGNVDACVITAAGAKMLRALSSPTKPIERSSQYRFAPGTTPVLSQTVVPLTLELVEETVQAMDVE
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.  This subunit is involved in antigen processing to generate class I binding peptides (By similarity).
What are the official names of this protein?
Proteasome subunit beta type-10, Proteasome subunit beta-2i.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MTLD_BUCAI
Sequence: MKALQFGAGNIGRGFIGKTLSESGFSVIFSDVNQNIVDAINYNREYFVKIIGSNQNKTVNIKRVSAINSNDSNIKKIISSVDLITTAVGPTALEKIALIITQGIIFKIKNQFTKPLNIIACENKIKSSSFLKQVVLKNLPIKYHDYLNKYIGFIDCSIDTIIPAINNKDDLFLTVEEFKEWIVNINQFKGAVPKIVDMKFSNNLDAFIERKLFTLNTGHAIAAYLGLIKNYKTIQDAISDKKIRVIVRSAMEESGSVLIKRYNFNKNDHLDYIEKIFLRFENPFLSDKLERIGRNPLQKLRREDRLIKPFLGAFEYNLPYSNLAKGIAAAFYYHNKNDLESIELSSSIKKQGLESTIIKICDLPVNSKEVYSIILEYNLIKKIIR
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: APLP2_MOUSE
Sequence: MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKEEEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYDPFKGDDYNEENPTEPSSEGTISDKEIVHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLEEEPESVGPLREDFSLSSNALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
What is the function of this protein?
May play a role in the regulation of hemostasis.  The soluble form may have inhibitory properties towards coagulation factors.  May interact with cellular G-protein signaling pathways.  May bind to the DNA 5'-GTCACATG-3'(CDEI box).  Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity).  Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
What are the official names of this protein?
Amyloid beta precursor like protein 2, Amyloid beta (A4) precursor-like protein 2, Amyloid protein homolog, Amyloid-like protein 2, APLP-2, CDEI box-binding protein, CDEBP, Sperm membrane protein YWK-II.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus.
Protein: VL2_HPV13
Sequence: MAHSRARRRKRASATQLYQTCKASGTCPPDVIPKVEQNTLADKILKWGSLGVFFGGLGIGTGSGTGGRTGYVPVGSTPRPAISTGPTARPPIVVDTVGPTDPSIVSLVEESAIINSGVPDPLPPVHGGFEITTSQSATPAILDVSVTTQNTTSTSIFRNPVFSEPSITQSQPSIESGAHVFISPSTISPHSTEDIPLDTFIVSSSDSNPASSTPVPATVARPRLGLYSRALHQVQVTDPAFLSSPQRLITFDNPTYEGEDISLQFAHNTIHEPPDEAFMDIIRLHRPAITSRRGLVRFSRIGQRGSMYTRSGKHIGGRVHFFKDISPISAAAEEIELHPLVAAAQDHSGLFDIYAEPDPDPVAVNTSGSLSSASTPFAQSSLSSAPWGNTTVPLSLPGDIFIQPGPDITFPTAPTVTPYNPVTPALPTGPVFITASGFYLYPTWYFTRKRRKRVSLFFTDVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: METK2_VITVI
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLQQDPDSKVACETCTKTNMVMVFGEITTKANVDYEKIVRDTCREIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYHNDGGARVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDREILKIVKENFDFRPGMISINLDLKRGGNGRFLKTAAYGHFGRDDPDFTWEVVKPLKWEKTQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_DEHMC
Sequence: MAKQKFDRSKPHCNVGTIGHVDHGKTTLTAAITKTLSTKGWADFRAYDQIDNAPEEKARGLTIAISHIEYQTETRHYAHIDCPGHADYIKNMITGAAQMDGAILVVSAPDGPMPQTREHVLLIHQVEVPAVVVALNKCDMMDDEELLELVELEVRELLTKNSFPGDEIPVVRVSAIKALECGCGKRECEWCGRIWKLMDAVDTYIPIPPRPVDKPFLMKVEDVFSIKGRGTVATGRVERGVIKGGDEVDLVGLHHEPRKIVVTSLEMFHKILDTAEPGDAVGLLLRGVEREDIERGMVLAKPGSIKPHVNAEAEVYVLSKDEGGRHTPFFNGYKPQFFFGTTDVTGEIHLPEGVEMVVPGDHVKMKISTIYPVAMEKGMRFAIREGGKTVGAGAISQVLA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCL7A_MOUSE
Sequence: MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPETNPPVPSDGTEAKADEAQADGKEHPGAEDASEEQNSQSSMENSVNSSEKAERQPSAESGLAAETSAVSQDLEGVPPSKKMKLEASQQNSEEM
What are the official names of this protein?
B-cell CLL/lymphoma 7 protein family member A.
What is the protein family that this protein belongs to?
Belongs to the BCL7 family.
Protein: RL25_NEOSM
Sequence: MVVSIECIPRTSFGRNSANVLRRSGFVPAVIYGKERENINVAISVRDVSKHFAVLSGSGVVELSCEGKVYKVVPKAYELHPVSSVVLHLDFVFAGEHASKFQVPLNFVNSGKSEAIRLGAMLNIVKRTVLVRCTAANLPKSIPVDIENAKVGDSIKFSDLVFPDGVVPLARDANSVVATVVGKKVKAGTVAATA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL31_ECO8A
Sequence: MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKCHPFFTGKQRDVATGGRVDRFNKRFNIPGSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: LPXC_SHEWM
Sequence: MIFQRTVKEMVKTTGVGLHSGNKVTLSIKPAPVNYGIVLVRTDLEPAVSIPAKADQVRETTMCTALVNDDGVRISTIEHLFAALAGLGIDNALIEVDAPEIPIMDGSASPWVFLLQSVGIQEQSAAKKYLRIKDTIRVEDGDKWAELKPFNGFRVDFAIDFNHPEIARSQQHMVMDFSTSAFVRDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYKVLNPDGLRYEDEFVKHKILDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRALLAQQDAWELVSFEKDEAPVSFSVPAGAVFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: MUTH_ECO57
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAP1B_RAT
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWSNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL
What is the function of this protein?
GTP-binding protein that possesses intrinsic GTPase activity.  Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.  Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.  Plays a role in the establishment of basal endothelial barrier function (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1b, GTP-binding protein smg p21B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity).
Protein: UTP16_SCHPO
Sequence: MQSSRKIMILKRNIKGLKSSAIIATYLTLNKLFIDKFCKTQESTYPIHFVHCHFGGIKKFHSHCQLSSSYTNSGQKSFKSFNSLRFIVLKSKTCLLRYKLLIKTFCCITYSKIENLSNTRMARLTAPSKGPSFSNLNKPNDLLKAEIEDNEASHYSQNQSSDSDSDEAPEEVSLKSSSDEVKKRLQRLKGNELQLRKAEREKRRLQNERNRERNAQRVSASKLDLAILEAAEVEEINSTTEIEEKVDEASLDLYTPKGHKIVFPNNEIPKKRTRSFRKGDFKVSVLKETNDPLLAPNYEKKLSQRKRDWINRQSVPRASKRRRPLTY
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.
What are the official names of this protein?
Probable U3 small nucleolar RNA-associated protein 16, U3 snoRNA-associated protein 16.
What is the protein family that this protein belongs to?
Belongs to the UTP16 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL30_GEOKA
Sequence: MAKKLAITLTRSVIGRPEDQRVTVRTLGLRKMHQTVIHNDNPAIRGMINKVAHLVKVKEIEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RN139_HUMAN
Sequence: MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFCIVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRERNGVIQHTGAAAEEFNDDTD
What is the function of this protein?
E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439).  Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873).  Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067).  Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569).  This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767).  In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569).  The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569).  Required for INSIG1 ubiquitination (PubMed:20068067).  May be required for EIF3 complex ubiquitination (PubMed:20068067).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF139, RING finger protein 139, RING-type E3 ubiquitin transferase RNF139, Translocation in renal carcinoma on chromosome 8 protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATRA_TAPPA
Sequence: MAPTAVFSNPATNPVANLKASVKTAEGVPATLNDLLLQATEMYPSHELSFITSSAHDSSVQARTFQDFNQRVRNLASALAAWKKPAGEVVVVYLTEHEDNMSAVWACLLAGLVPCLQPALSAQQEHKEGHIAHIRKLFGSATWLTNDAGAMQLDTIKGLDVHLFSDLLASAEKSSVAANYVARQSQPDDEAILFLTSGSTGFSKAVVHTHRTIINACIAKGANYRLTPQTNILNWVGFDHVAGSLEMHIAPLLYGCSQLHVHASAILSDPLLLLRLIDERSIDIAFAPNFLLAKMVRDLEKRTDLHGKFDLSSLRRMNSGGEAVVSKTAVAFVQLLKKLGRNPSKVSFKVAAGFGMTETCAGCIYDVVDLAENSPKHEFLALGAPVHGCEMRIVDPEDGATPRSDGQPGELQVRGPMIFVRYYNNPEATKSSFVEGGWYRTGDIGIIENGNMRLSGRIKDTVIVHGVSYGIPELETYLQTVQGVTHSFLAAAPYRAPGQETEGFVVFYAPTFDLQGDDASKKLSETHRAIKDVSVKMMTLPPQHIVPIPMDQMEKTTLGKLSRARLLSQFVQGALAKHVARAEELISMARGASFVTPSTDDEKALAAIYAGIFNLQSNEVSARDNFFELGGTSIDVIRLKREGEAHFGLSEIPIIQILKNPIVSDLAKYVNGLVNNDASANEYDPIVPLQLSGDKTPIFFVHPGVGEVLIFVNLAKYFQNERPFYAFRARGFEPGHPFFGSMDEMVTSYANAMKKTQPKGPYAIAGYSYGGVVAFEVAKRLESMGEEVKFVGLINIPPHIADRMHEIDWTGGMLNLAYFLSLVTKQDATDLHPKLKTMTKEEQLEVVWKLAPPERVTELQLTPGKLDHWVSIAGSLIECGKSYNPGGNVSAVDVFYAIPLKGSKEDWLNKQLKPWSQFSRGEPQFIDVPGQHYTLMDFDHVPQFQKIFRGRLEARGL
What is the function of this protein?
The L-tyrosine:2-oxoglutarate aminotransferase atrD and the atromentin synthetase atrA catalyze consecutive steps to turn over L-tyrosine into atromentin, which represents the generic precursor molecule for the entire terphenylquinone and pulvinic acid family of pigments, which are widely distributed secondary metabolites in homobasidiomycetes (PubMed:18805498).  The first step is catalyzed by atrD which converts L-tyrosine in to 4-hydroxyphenylpyruvate (4-HPP) (PubMed:18805498).  Adenylation of two 4-HPP monomers by the atrA adenylation (A) domain, ester bond formation between monomers and atrA, and symmetric C-C-bond formation between two monomers by atrA leads to atromentin (PubMed:18805498).
What are the official names of this protein?
Atromentin synthetase, Atromentin biosynthesis protein A, Nonribosomal peptide synthase atrA.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: ALT4_ALTSO
Sequence: MDIQQGGNDLISLAATIRTELQQKLSSKARIHLPFDEDRTEFDKANLRFTQYERPTYLAIVDPVCEDDVIEAVKYARGKGIPFTPRGGHHSVTTTMGRFQNGICINMRPLNQMRWYAEKRHVTIGGGAITDEFVRFVHDLGMEVTFGAGLGRLQGKYGFLNDNMVSCKLVLADGSTVIASKDSHPDLFWALRGAGHNFGIALEATFQVYPQAHGGIHHTWDLEYTLDQCDEVFRTLNSVYESMPAELAIFILWLRQSSGRKHIILVNLVWSGPAAGADPYVQRFESLQPVLNSGRKSVPWPELPFSTYKEINKLFCNPEIWLRGPYKMMGAACVERFDLKTTREFFESVKSLSEEWEDRGWFSAMFECLPDQRVREISDDATAFPWRAGSNHFLMLNATPKRMEDRKVFEDHLNYWKRRFIETSGYGRLQQYVSYGNGTSTMKDPPEALYGYEPWRLEKLRNLKQKYDPDNVFRWYQPLLEP
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of alternapyrone derivatives (PubMed:16356847).  Alternapyrone is a decaketide with octa-methylation from methionine on every C2 unit except the third unit (PubMed:16356847).  All the domains in the polyketide synthase alt5 are apparently involved in alternapyrone synthesis, that is, the 8 CMeT, 7 KR, 7 DH, and 4 ER reactions in the 9 KS-mediated condensation steps required for alternapyrone synthesis (PubMed:16356847).  the alternapyrone produced by alt5 might be intensively modified by cytochrome P450 monooxygenases alt1, alt2 and alt3 and FAD-dependent oxidoreductase alt4 present in the alt gene cluster (PubMed:16356847).
What are the official names of this protein?
FAD-linked oxidoreductase alt4, Alternapyrone biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: RLME_HAEIN
Sequence: MGKKKRSASSSRWLNEHFSDQFVQKAHKQKLRSRAYFKIDEIQQTDKLFKQGMTVVDLGAAPGGWSQYVVSQIGGKGRVIACDILEMDPIVGVDFLQGDFRDENVLNALLARVGEDKVDVVMSDMAPNFSGMPSVDIPRAMYLVELALDMCKQVLASKGSFVVKVFQGEGFDEYLREIRSLFDVVKVRKPEASRGRSREVYIVATGYKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUK_BACAA
Sequence: MSVNRILVINPGSTSTKIGVFDNERPVLEETIRHDEEQIGKYKRIIDQYEFRKETILEVLHSHGINISKLNAVCGRGGLLRPIEGGTYTVNDAMLEDLKNGFSGHHASNLGGILAYEIASGLNIPAFIVDPVVVDEMEPIARISGIAGMERKSIFHALNQKAVARKVAEELNHKYEDLNLLVTHMGGGITVGAHKKGKVIDVNNGLNGEGPFSPERAGTVPVGQLVEMCFSGEYYRDEMVKKLVGQGGLVSLIGTNDAIKVEQMVEKGDPEATLIYKAMAYQVAKEIGGASAVLHGKIDAIVLTGGLAYSKILVDEIKERVDWIADVIVHPGEDELQALAEGALRVLREEEAPKEYIVREKETVARG
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCN2_LACLL
Sequence: MKKKTYQFEKFLKNTFDQFSIKQNEVLVEDDLNDIIMNVCGKALVLMINEKREMNLLMGNTPEERYQYFENEYSSTGKAFEEIKDKFPVIYIDLKNSINSYLKLVSQIMKDFKKDYSLLVERKIIEEHSTISTMKIKGDLHNGKAVIEITTNKSKLIYKPKSLSNDVFFNNFLKYMDSFFIKEGKSTKYKENFYLVNTLDMKTYGWVEYVDKKPINSFEEARNYYRKIGVLLSVAYTLNLTDLHFENVISQGENPCIIDLETMFNMPMFVKDYKNESRNIINGKIMDSVVSTGMLPVLGIDSLFGGDPSGILGGTFSKEERVIINPFRDDIKFQKIVVRSVFKDHIPFFNNNNEKRYCKPKDYVNDIIKGFEKTYKIIVKNKEKILGFLKKESSSVTCRILFRNTMEYSVLLNAAKSPVYSNKREEIFEKLSTFNRGLGNDIIKSEISQINTLSIPYFNCQVDSNLIKNMDGETIFEHTLTPFKCFLSKYRRLCVDDMEQQVKLIRFSIQSQEQLFKDGEQFSLYKKQKGSQEDLLIAINELSSILENNAYIGTSDDTINWMSLGIADNDQILFESLENDIYKGISGIGLALLEYYEFYPNINTKKILKLIYKNISKDFINTNNEPQNYGFYVGLIGEYSFLRKYEKVFHKTSSCNILKNILKDFTPEKCQTILPSDDVIAGEAGIIIYISNLNNYLEYRDEIDILLKSLSNKIKLKESIASYAHGNSGIATAFVHGYKVTKNEKYLKIFHELWNLENSSKLRRGWTDSRKVDSSYSSQWCHGASGQAIARMEWITVNKTARFLSNSELIKVKKELGELIDILKKEGMYTDNFCLCHGILGNLLILNTYQENFDNKNINLKNEILNNYYSVCNYGLNKGWICGLGTEFYSYGLMTGISGILYGLIRQVKQKNNFGVLMPYVD
What is the function of this protein?
Could be implicated in the processing or the export process of the lantibiotic lacticin 481/lactococcin DR.
What are the official names of this protein?
Lacticin 481/lactococcin biosynthesis protein LcnDR2.