PharMolix/UniProtQA huggingface dataset:
Protein: Y8207_DICDI
Sequence: MSFKSDNSNSILKNFKRTIIHPNGTNGEFNNNNNINNNNNNNNNNNNNNNNNNNNNSNNNLPIKRKVPESYSQYQYHQQKQVQKQNSQFHKESELNEMELDVEKEYYEQSKDIIGFKRFRSLDSNNNLNSNQFIENNQKSQFFNNNNNNNNNNNNSNNNKNFDQKDNEQEDIIKYMEFLSDIEQLNSDLKESKDNLESISIEMVLLETRLKGLLGLNTLRIIQNDQEQFLFKNKK
What are the official names of this protein?
Putative uncharacterized protein DDB_G0289009.
Protein: SYL_CROS8
Sequence: MQEQYRPEEIESKVQLHWEEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNINYMKNQLKMLGFGYDWSRELATCTPEYYRWEQQFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFDVQNSDEKLTVYTTRPDTFMGVTYLAVAAGHPLAQAAAAANPALGDFIAECRNTKVAEADMATMEKKGVDTGLKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYSLPIKPVILTAEGTAPDLSEQALTEKGVLFNSGEFDGLDFEAAFNAIADKLAAKGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPADQLPVILPEDVVMDGITSPIKADPEWAKTTVNGQPALRETDTFDTFMESSWYYARYTCPQYKEGMLDEKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGANGERNWVSPKDAIVERDEKGRIVKASDAAGHELVYTGMSKMSKSKNNGIDPQEMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWRLVYEHTSLGDAPALNVDALNDDQKALRRDVHKTIAKVSDDIGRRQTFNTAIAAIMELMNKLAKAPQEGEQDRALMREALLAVVRMLNPFTPHVSFTLWQELKGEGDIDNAPWPQADDSAMVEDTTLVVVQVNGKVRGKITVAADATEEQVRERAAQEHLVAKYLAGVTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOVO_CROAU
Sequence: LAAVSVDCSEYPKPACTMEYRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: CNGA3_MOUSE
Sequence: MAKVNTQCSQPSPTQLSIKNADRDLDHVENGLGRVSRLIISIRAWASRHLHDEDQTPDSFLDRFHGSELKEVSTRESNAQPNPGEQKPPDGGEGRKEEPIVVDPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADVLYVLDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGVNYPELRFNRLLKFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYARLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRVEFQAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKRALEEKGRQILMKDNLIDEDLVAARVDTRDVEEKVEYLESSLDILQTRFARLLAEYSASQMKLKQRLTRLESQMNRRCCGFSPDRENSEDASKTD
What is the function of this protein?
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger.  This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.  Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity).  Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3.
What are the official names of this protein?
Cyclic nucleotide-gated cation channel alpha-3, Cone photoreceptor cGMP-gated channel subunit alpha, Cyclic nucleotide-gated channel alpha-3, CNG channel alpha-3, CNG-3, CNG3.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: H2A3_STRPU
Sequence: KAKGKAKRRSSRAGLQFPVGRVHRFLRKGNYANRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKL
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A-beta, sperm.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DNLJ_STRP6
Sequence: MKKRIKELTDLLNRYRYDYYTKDAPSVSDSDYDKLYRELVTLEQSYPEYVLQDSPTQQVGGTILKGFEKYRHQYPLFSLQDAFSREELDAFDKRVKAEFPNATYLAELKIDGLSISLSYENGFLQVGATRGDGNIGENITENIKKIKDIPHQLSEPLTITVRGEAYMSRQSFKAINEARQENGETEFANPRNAAAGTLRQLDTSVVAKRQLATFLYQEASPTARNQQNEVLAELADLGFSVNPYYQLTSSMDEIWDFIKTIEAKRDQLAYDIDGVVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLNVVMSKRNQQEVMLIPKLCPSCGSELVHFEDEVALRCINPLCPSLIQRSLEHFASRDAMNITGLGPAIVEKLFLAGFVHDVADIYQLTKEDFMQLDGIKEKSADKLLAAIEASKSNSAEKLLFGLGIRHIGSKVSRLILEVYGDISALLTAKEEEIARIDGLGSTIAQSLTQYFEQKTAAILVDELKTAGVNMHYSGQKVNSDAALFGLTVVLTGKLNQLNRNEAKDKLEALGAKVTGSVSKKTDLVIAGSDAGSKLEKAKSLGIRIEDEDWLRKF
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ZP2_MOUSE
Sequence: MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNYRTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCSVTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKGVDPSSSEITKDIIAKDIASKTLGAVAALVGSAVILGFICYLYKKRTIRFNH
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP2 may act as a secondary sperm receptor.
What are the official names of this protein?
Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein 2, Zp-2, Zona pellucida protein A.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPA subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 2]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: SOCB_CAUVN
Sequence: MKKHRLPDTELARIAPLAPDARRKALLKFKNGFPDFSYEPTRRRLPELTNAQPSLLSLGDTEWSKIESGLKRLKNEKEAASNIEVAELLYNFIREEKYIAVMEPFGKLQLGAGVAISYWSDAIFFGPDGPTIFGFDFRRAGGFNDSARRFAFSAQHEHIRQRGDDYATAKLGLVQFPALRNGTRKVRVEFADQVELIPYDELIQMARETYSVWFEILEQREDEARKTGTGGSWWDGD
What is the function of this protein?
Toxic component of an atypical type II toxin-antitoxin (TA) system.  Upon overexpression in the absence of its cognate antitoxin SocA, leads to inhibition of colony formation, cellular filamentation, incomplete DNA replication and induction of the SOS response.  Exercises toxicity by binding the beta sliding clamp (dnaN), blocking DNA replication and leading to premature replication fork collapse and incomplete cell division.  Unlike most type II TA systems, the SocB toxin is unstable and targeted by its cognate antitoxin SocA for degradation by ClpXP.  Not toxic upon expression in E. coli.
What are the official names of this protein?
DNA replication inhibitor toxin SocB.
What are the subcellular locations of this protein?
Cytoplasm. Note=A tagged overexpressed form of SocB forms a discrete locus during DNA replication which co-localizes with beta sliding clamps (dnaN), but the locus disperses early. Loci formation depends on DnaA, the replication initiator protein (PubMed:24239291).
Protein: ARAA_SHESA
Sequence: MKAFKQKQVWFITGSQDLYGPKVLEQVAKNSEQIVHGFNESSAISIEVVYKPTVKSPREIHAVCQAANSDENCVGVILWMHTFSPAKMWIAGLNELSKPFMHLHTQFNAELPWSEINMNYMNTHQSAHGCREFGFIGTRMRKERKVVVGHWQSSDVQAQIDDWCRAAAGWHESQNLRIARFGDNMRQVAVTEGDKVAAQIQFGYEVHAYSLGELNEAIADIAEGDVTAQLDRYASEYQVGNELFGDEYQLDRLRKEAKIELGLTQFLTQGGFGAFTNCFENLTGMTGLPGLATQRLMANGFGYGGEGDWKTAAMVRIMKVMGQGRAGGTSFMEDYTYNFGATDQVLGAHMLEVCPSIAAAKPRLEVHRHTIGVRCDVPRLLFTGKAGPAINVSTIDLGNRFRIILNELDTVTPPQDLPNLPVASALWEPRPNLAVAAAAWIHAGGAHHSAYSQAITTDQIVDFAEMAGAELVIIDADTKIREFKNELRQNSVYYGLARGL
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: TRPD_CUPMC
Sequence: MSITPQEALTRCIEHREIFHDEMLHLMRQIMQGQISPVMAAAILTGLRVKKETIGEISAAAQVMREFANHVTVKDRENFVDIVGTGGDGSHTFNISTASMFVAAAAGAKIAKHGNRGVSSKSGSADVLEALGVNIMLTPEQVGECIEQTGIGFMFAPTHHPAMKNVAPIRKEMGVRTIFNILGPLTNPADAPNILMGVFHPDLVGIQVRVMQRLGAQHAIVVYGKDGMDEVSLGAATLVGELKDGEVREYEIHPEDFGLSMISNRGLKVADAVESKEMLLEALSDVPGTPREIVSLNAGTALYAANVASSIEDGIRRAREAIASGAAREKLDQFVRATQQFK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RS17_RICB8
Sequence: MPKRVLQGVVISSKTDKTVTVKVERRFKHPIYKKFIKVSKKYAAHDPNNKFQEGDKVNIIESRPISKTKTWVVINEE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: UBIG_BRUC2
Sequence: MTETARTTIDASEIEHFSRIAAQWWDPQGKFRPLHKFNPTRLAYIKEKVCAKFNRDPNAPRPLEGLRFLDIGCGGGLLCEPMARLGATVIGADASATNIEVAKIHAAQSSLDIDYRATTAEALADAGEKFDVVLNMEVVEHVSDVDLFMSATSAMVKPGGLMFVATINRTLKAYGLAIIGAEYVLRWLPRGTHQYEKLVRPEELEAAFSKADLRLIDKLGVTYNPLADSWNRSRDMDVNYMVLAERPA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: Y782_AGRFC
Sequence: MGSTSDKIAGKTNEVAGKVKKNVGEATGNNELRAKGAAQETKGKVQTSVGKAKDAVKGAVDRM
What are the official names of this protein?
UPF0337 protein Atu0782.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: KATG_SYNE7
Sequence: MTATQGKCPVMHGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDVAALKQDLQALMTDSQDWWPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGTGNQRFAPLNSWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYESMGLKTFGFAFGREDIWHPEKDIYWGPEKEWVPPSTNPNSRYTGDRELENPLAAVTMGLIYVNPEGVDGNPDPLKTAHDVRVTFARMAMNDEETVALTAGGHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSGIGRNAVTSGLEGAWTPHPTQWDNGYFRMLLNYDWELKKSPAGAWQWEPINPREEDLPVDVEDPSIRRNLVMTDADMAMKMDPEYRKISERFYQDPAYFADVFARAWFKLTHRDMGPKARYIGPDVPQEDLIWQDPIPAGNRNYDVQAVKDRIAASGLSISELVSTAWDSARTYRNSDKRGGANGARIRLAPQKDWEGNEPDRLAKVLAVLEGIAAATGASVADVIVLAGNVGVEQAARAAGVEIVLPFAPGRGDATAEQTDTESFAVLEPIHDGYRNWLKQDYAATPEELLLDRTQLLGLTAPEMTVLIGGLRVLGTNHGGTKHGVFTDREGVLTNDFFVNLTDMNYLWKPAGKNLYEICDRKTNQVKWTATRVDLVFGSNSILRAYSELYAQDDNKEKFVRDFVAAWTKVMNADRFDLD
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: PAND_BURCJ
Sequence: MQRHMLKSKIHRAAVTHCELHYEGSCAIDEDLLEAAGLIENERIDIWNINNGERFSTYAIKGERGSGMISLNGSAARRAQLGDLVIIAAFAMVDEAELQAGWKPKLVFIDEGNKIKGHRDHVPTQNWT
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BEX3_MOUSE
Sequence: MANVHQENEEMEQPLQNGQEDRPVGGGEGHQPAANNNNNNHNHNHNHHRRGQARRLAPNFRWAIPNRQMNDGLGGDGDDMEMFMEEMREIRRKLRELQLRNCLRILMGELSNHHDHHDEFCLMP
What is the function of this protein?
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF.  Plays a role in zinc-triggered neuronal death.
What are the official names of this protein?
Protein BEX3, Brain-expressed X-linked protein 3 homolog, Nerve growth factor receptor-associated protein 1, p75NTR-associated cell death executor.
What is the protein family that this protein belongs to?
Belongs to the BEX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
Protein: EX7S_AGRFC
Sequence: MNMTENANTADVSGYSFEKAVAELESIVARLERGDVALDESIAIYERGEALKKHCETLLNAAEKRIEKIRLDRAGKPQGVEPLDGE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCRI1_HUMAN
Sequence: MTSSPVSRVVYNGKRTSSPRSPPSSSEIFTPAHEENVRFIYEAWQGVERDLRGQVPGGERGLVEEYVEKVPNPSLKTFKPIDLSDLKRRSTQDAKKS
What is the function of this protein?
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition.  Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s).  When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).
What are the official names of this protein?
Mapk-regulated corepressor-interacting protein 1, Granulin-2, Protein FAM195B.
What is the protein family that this protein belongs to?
Belongs to the MCRIP family.
Protein: Y1857_NITEU
Sequence: MSFQGEITHLSQKGLGVVQHPENGLSYFVAGTWPGDRGEFEITDRALNNRKYGYARLIRLIQSSRHRKTPECRFLGFSGNDCSGCPWMIADYDSQLEQKKNRFLYAMHRVGFDLADLNIGAVQPSPDLFGYRNRFQVKTDGEKLGFVAEGSHHIVPIEDCLILNPACRQHLQTLRKHLPSREWSPAPGDDWNFIDLDDQSPAEPVLLNWKQPFRQGNDAQNQWMRSWLKYALEQHGHSHKIVELFCGSGNFTEVIAQTGCPEILAYEADPQAITVLRQKNLPGVDARTADLYHPFIWKILKKNVQDAGILVLDPPRSGLKTLRGFFDAFAALETICYISCDPVTFARDAWIFCKNGWKFTDIQLIDLFPHTPHIEITATFHKQWGNTKKGNKR
What are the official names of this protein?
Uncharacterized RNA methyltransferase NE1857.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: AROF_CANAX
Sequence: MFITNEHVGDRSRMEDWRIRGYDPLTPPDLLQHEYPLTPESQKIIVEGRNAACDILNGKDRRLIGPCSIHDPQAALDYCERLYQASEKHKGELLIVMRAYLEKPRTTVGWKGLINDPDIDGTFHINKGLRIARKLFVQLTSKLPIAGEMLDTISPQFLSDLFSVGAIGARTTESQLHRELASGYHSQLDSKTVPMVLWVLPLTPLRAASHPHHFLSVTKPGVVAIVGTDGNQDCFVILRGGKKGTNYDAKSVQETQEELIKSKVVTEMKPGPRIMVDCSHGNSNKDHRNQPKVAQVVAEQVAGGDKSICGLMIESNINDGRQDVPPKEQGGKDALKYGVSITDACIGWETTEEVLEVLANAVKTRRSL
What is the function of this protein?
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: DAPD_PSYA2
Sequence: MSLQQTIEQAFENRNEYSPATMPQDVRDAINQVLEQLDNGTLRVAEKKDGEWVVNQWAKKAVLLSFRLNDNYVQAAGEHIQFYDKVPTKFADWTEAQFKEAGVRVVPPAVARKGSYIAPGAVLMPSYVNIGAYVDQGAMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEIVEGVIVEEGAVISMGVYIGQSTRIYDRETGEIHRGRVPAGSVVVPGSLPSEDGTHSLYAAIIVKKVDAQTRAKTSVNELLRLA
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSK_PASMU
Sequence: MIKRISEKFTPKQYLLAFFFLVGMLFGVYLIVAWSSYSPLDNSWASSSYIPTTINKAGRFGAWFIDLFFVLFGHVGHIIPFLIFGISFYFWRRKGKVPFSFFRLSLWLLGFSIFLCGVCVLFTLLFSNTPYYLSGGVLGGSLVTAFFPMLDFVGLMLSGTLLALLGFVLCSGTSLIRSCIYFYDWLTMKNPTQTQEEETISTTPVQQELALQEEPSIQSINEGERVFVSEAPSATMDEEKSLINIENLIQIQGLESASQAKESTIPTVPLDDVNQVELGGYAVEPELALPSVSVAFVEDTALSSSEAEHEDSKPFTTQIPHTAGEPLVATEFAMPKVSLSPLDTSLSDNSEIAREDESDLARQFAAQEQQRREEMALRAKALNAEEALQTILAEPEIRQNSTADVSDSTTPHYKPYGESLIHPALQQKVTTQVKPTTPMPSLDLLEHRPSQAHRITQEEIIETSQRIEHQLRNFGVKATVKDVLVGPVVTRYELELQPGVKASKVSSIDTDLARALMFRSIRVAEVIPGKPYIGIETPNVNRQMVTLREVLDSDVFRQSNSLLSMALGKDISGKPVVVDLAKMPHLLVAGSTGSGKSVGVNTMILSLLFRVKPEEVKFIMIDPKVVELSIYDGIPHLLTEVVTDMKKAANALRWCVDEMERRYQLLSALRVRNIEGYNEKIEEYEAMNMPIPNPIWRPGDTMDTLPPALEKLSYIVVIVDEFADLMMVAGKQVEELIARLAQKARAIGIHLILATQRPSVDVITGLIKANIPSRIAFTVASKIDSRTILDQVGAEALLGRGDMLYSGAGSSDLVRVHGAFMSDDEVARVVDDWKARGKPNYIEGILDSGEDEATESNGANSDAGELDDLFDEVVEFVTSTGTTSTSYIQRKFRVGFNRAARIMDQLEEQGIVSAMQNGKREVLARRSSDF
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: RL22_AERPE
Sequence: MPRWGYSVKLRDESEVAKAVLRNVPVHPKIMAEVARAISGMRVDEARRYLRAVIEKREAVPFRRAHGKQAHRRGLADKWGWPVGRYPVKAARYMLKLLDNVEANAANKNLDVERLKIIHVAAHKGITLKRWMPRAWGRATPRNRVHSHIEIMVREV
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: IL19_HUMAN
Sequence: MKLQCVSLWLLGTILILCSVDNHGLRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
What is the function of this protein?
Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373).  Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913).  Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity).  Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624).  In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763).
What are the official names of this protein?
Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_PYRAE
Sequence: MGGLKKPKKKYLAGKPKKIWNKQLLLEELQLMGEYGLRNKKELWLARARLKWITRRARSLLSMTAEERAPLEMPFKEKLYKMGFIEDPNVQLDRILSLDVRAILERRLQTIVYRMGLAKSIHHARQLIVHGHVAVAGRRVTSPGFLVPRELEDKISLIQ
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SELO_PSEPF
Sequence: MKALDELTFDNRFARLGDAFSAHVLPEPIDNPRLVVASPAALALLDLDPAMADTQEFAELFGGHKLWADAEPRAMVYSGHQFGGYTPQLGDGRGLLLGEVYNAAGEHWDLHLKGAGQTPFSRMGDGRAVLRSSIREFLASEALHALNIPSSRAACVIGSDTPVWREKQERAAMVLRLAPSHIRFGHFEYFYYTKRPEQQKLLGEHVLAMHYPECLEQPEPYLAMFREIVERNAELIAKWQAYGFCHGVMNTDNMSILGITFDFGPFAFLDDFDANFICNHSDDQGRYSFSNQVPVGQWNLSTLAQALTPLISVEALRETLGLYLPLFQAHYLDLMRRRLGFTTAEDDDQMLLEQLLQLMQNSGVDYTLFFRRLGEESAEQAVARLRDDFVDIKGFDAWGERYVARVARDGATDQEQRRARMHAVNPLYILRNYLAQKAIDAAEQGDYSEVRRLHAVLSNPFEEQPGMESYAERPPEWGKHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: MMPL5_MYCTO
Sequence: MIVQRTAAPTGSVPPDRHAARPFIPRMIRTFAVPIILGWLVTIAVLNVTVPQLETVGQIQAVSMSPDAAPSMISMKHIGKVFEEGDSDSAAMIVLEGQRPLGDAAHAFYDQMIGRLQADTTHVQSLQDFWGDPLTATGAQSSDGKAAYVQVKLAGNQGESLANESVEAVKTIVERLAPPPGVKVYVTGSAALVADQQQAGDRSLQVIEAVTFTVIIVMLLLVYRSIITSAIMLTMVVLGLLATRGGVAFLGFHRIIGLSTFATNLLVVLAIAAATDYAIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQTLGVPLAIGMVIVVAAALTLGPAIIAVTSRFGKLLEPKRMARVRGWRKVGAAIVRWPGPILVGAVALALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAAERHFSQARMNPEVLMVESDHDMRNSADFLVINKIAKAIFAVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTARMLEQVNDIQSNIDQMERMHSLTQQMADVTHEMVIQMTGMVVDVEELRNHIADFDDFFRPIRSYFYWEKHCYDIPVCWSLRSVFDTLDGIDVMTEDINNLLPLMQRLDTLMPQLTAMMPEMIQTMKSMKAQMLSMHSTQEGLQDQMAAMQEDSAAMGEAFDASRNDDSFYLPPEVFDNPDFQRGLEQFLSPDGHAVRFIISHEGDPMSQAGIARIAKIKTAAKEAIKGTPLEGSAIYLGGTAAMFKDLSDGNTYDLMIAGISALCLIFIIMLITTRSVVAAAVIVGTVVLSLGASFGLSVLIWQHILGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRPVPQPWPSPASARTFALV
What is the function of this protein?
Part of an export system, which is required for biosynthesis and secretion of siderophores.
What are the official names of this protein?
Siderophore exporter MmpL5.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.