PharMolix/UniProtQA huggingface dataset:
Protein: LZTS1_RAT
Sequence: MGSVSSLISGHSLHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDMGGQTGVDFDPATPPKLMPFSSQLEMSSDKAAVRPTAFKPVLPRSGAILHSSPESTNHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKVEKGSSCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPASQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQMEVNAKASEILSLKAQLKDTRGKLEGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELLELRAQAALHRDAAPLGPPGIGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLEKALQQLARGDIAGEPFEIDLEGADIPYEDIIATEI
What is the function of this protein?
Involved in the regulation of cell growth.  May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation.  May act as tumor suppressor (By similarity).
What are the official names of this protein?
Leucine zipper putative tumor suppressor 1, PSD-Zip70.
What is the protein family that this protein belongs to?
Belongs to the LZTS family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cell projection, dendritic spine. Postsynaptic density. Synapse. Note=Associated with the plasma membrane and with microtubules (By similarity). Detected in dendritic spines, especially in the postsynaptic density.
Protein: RIR2H_MYCPA
Sequence: MNRTRSASMAQGGLNWDSLPLKLFAGGNAKFWNPADIDFSRDRADWERLTDDERSYATRLCAEFIAGEESVTQDIQPFMAAMRAEGRLGDEMYLTQFAFEEAKHVQVFRMWLDAVGVTDDLHHFLDDVPSYRTIFYEELPDCLNALTIDPSPAAQVRASVTYNHMVEGMLALTGYFGWHKICVERGILPGMQELVRRIGDDERRHMAWGTFTCRRHVAADDANWGVFETRMNELMPLGLRLIEEGFALYDPMPFDLSVDEFMAYASDKGMRRFGTIASARGRPLAEIDLDYTPVQLEDTFADEDARALAAV
What is the function of this protein?
Probable oxidase that might be involved in lipid metabolism.
What are the official names of this protein?
R2-like ligand binding oxidase, Ribonucleotide reductase R2 subunit homolog, Ribonucleotide reductase small subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family. R2-like ligand binding oxidase subfamily.
Protein: NGFV1_PSEAU
Sequence: MSMLCYTLIIAFLIGIWAAPQSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKVDDQELGSVANIIVDPKLFQKRQFQSSRVLFSTQPPPLSRDEQSVEFLDNEDALNRNIQAKRQNHPVHDLGEHSVCDSISEWVTKTTATDIKGNTVTVEVDVNLNNEVYKQYFFETKCRNPNPVPSGCRGIDSRLWNSYCTTTQTFVKALTMEGNQASWRFIRIDTACVCVITKKTDNL
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 1, v-NGF-1, vNGF-1.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYFA_METBF
Sequence: MSIQDNLTINEKKVLLALEEIGSASPERLEEKSGLQVDAAMQAAFMLEEKGLVSVSEKMLERYSLTKEGTEYTKTGLPERQIIDFLKKPTSLEELRGHFSPKMVGIATGWLVKKGWAKIENGVMVPSGKVNAGKDEETLAAFTGKAKTLEEIGSDQGTIKDLLKRKLVIKHEEKFRTVSITDAGNALATQGLVLEEEIAQLTPELLKSGAWKDKKFRPYRLDITPKSLYGAKIHPYRRLIEQMRQIFLEMGFAEIKGGIIQSSFWNFDALFQPQDHPARDMQDTFHLNSTCELPTEYFEKVAAMHEHGGDIDSCGWGGAWDKELSRRNVLRTHTTSVTVKYLADHPKSPVKAFCIDRAYRRETIDPTHTPEFEQLEGVVMDKNMSFADLLGLLAEFYHRMGFEEVRFRPGYFPYTEPSVEPEVYVDGLGWVELGGAGVFRREVSEPLGIKDPVLAWGLGVSRLAMLKLGLKDLRLLYQSDIDWLRKSEVCRT
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_LACAC
Sequence: MMTKLVINPVAFQLGSLSVKWYGIIMAVAIVLATWMAISEGKKRQIISDDFVDLLLWAVPLGYVGARIYYVIFEWGYYSKHPNQIIAIWNGGIAIYGGLIAGLIVLLIFCHKRDLPPFLMLDIITPGVMAAQILGRWGNFVNQEAHGGPTTLHFLQSLHLPEFVIQQMKIGGTYYQPTFLYESFFNLIGLIIILSLRHRKHVFKQGEVFMSYLLWYSVVRFFVEGMRTDSLYIFGIIRVSQALSLVLFIATIILWIYRRKVVKPKWYLQGSGLKYPYTRD
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPG_AERS4
Sequence: MTQSVHAETHGFQTEVKQLLSLMAHSLYSNKEVFLRELISNASDAADKLRFKALSDASLFENDGQLRVRLVVDKENRTLTISDNGIGMTRDQVIEHLGTIAKSGTAEFFKNLSGDQGRDSQLIGQFGVGFYSAFIVADKVTVVSRAAGTAPEQGVQWESEGEGSFTVADVTKEGRGTDVILHLRAEEEEFLDDWRLRAVVAKYSDHISVPVEMFKEGTPDREEDGETVVGTPGEWEQVNRATALWTRNPKEIKDEEYQEFYKHVAHDFEDPLLWGHNRVEGAQEYTSLLYVPARAPFDLYNREQKHGLKLYVQRVFIMDDAEQFMPTYLRFVKGVLDSNDLPLNVSREILQDNKVTVSLRKACSKRVLTMLAKLAKDDAEKYAKFWSEFGNVLKEGPAEDYANREEIAKLLRFASTAGEGEAQTVSLEDYVGRMKEGQQKIYYITADSFAAAKNSPHLEIFRKKGVEVLLMWERVDEWLMSHLTEFDGKQLVSVTRGELDLGDLEDEASKQAQEEAEKANAGLVERVKTSLGEAVKEVRVTHRLTDSPSCIVTDNHGMSTQMIKLMRAAGQPVPEQKYILELNPDHALVKKLDTIEDEALFGEWVTLLHEQAQLAEQGGLNDPASFVSRINRLLLQA
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_ACIAC
Sequence: MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASKTSDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGKIIADAMDKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQVAKAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAKRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALLRAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNAANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGMGGMGM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APRV1_MOUSE
Sequence: MRNPGGPGWASKRPLQKKQNTACLCAQQPARHFVPAPFNSSRQGKNTAQPTEPSLSSVIAPTLFCAFLYLACVTAELPEVSRRMATSGVRSKEGRREHAFVPEPFTGTNLAPSLWLHRFEVIDDLNHWDHATKLRFLKESLKGDALDVYNGLSSQAQGDFSFVKQALLRAFGAPGEAFSEPEEILFANSMGKGYYLKGKVGHVPVRFLVDSGAQVSVVHPALWEEVTDGDLDTLRPFNNVVKVANGAEMKILGVWDTEISLGKTKLKAEFLVANASAEEAIIGTDVLQDHNAVLDFEHRTCTLKGKKFRLLPVGSSLEDEFDLELIEEEEGSSAPEGSH
What is the function of this protein?
Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.
What are the official names of this protein?
Retroviral-like aspartic protease 1, Skin-specific retroviral-like aspartic protease, SASPase, Skin aspartic protease, TPA-inducible aspartic proteinase-like protein.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GP142_MOUSE
Sequence: MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 142.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTH_BURP6
Sequence: MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHFFKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRKDEQDLIDAAIERALAVMPTAIKGETERAMMQLHRNGA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBA4_CANGA
Sequence: MTDQDLLAQIELLKKENAQLKEKLKSQDDEQLSLEEYSRYGRQMIVEGTGGVVGQLRLKKAKVLVVGAGGLGSPSLPYLVGAGVGTIGIVDNDIVDTSNLHRQTIHNTAKVGMLKCESAKQVLKDLNPHVNINTYPVRLGPENAFSIFADYDIVMDCTDTPLTRYLISDVAVNLGKTVVSASGLGTEGQLTILNFNNIGPCYRCFYPVSPNPYAVSSCQEGGVIGPCIGLVGTMMAVETLKIIMGVYNNENFEPFLLSYSGFPIQSLRRFKMRGRQSKCQTCGDAPVITKEAIESGIIDYNIFCGSRNYNVCAEGERLTAKEFDENYGPEFSGNNKVLLDVRPSHHFDISHFNNAVNIPLKELRDMDGDISTLQSRIPNINKNSEVVVLCRYGNDSQLATRMLKDEFGITNVKDVAGGFFKYIDDVDQSIPKY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1.  Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase UBA4, Ubiquitin-like protein activator 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEN15_NEUCR
Sequence: MESGSTPPTDKQIRENEQDGTGHQGKLLARPTSTRQQQQQQQQQPSHSVSQSVSQSPQTQDCLTIVANMSADQHLQALTKVVVNNLENQHDWTQVQIHIQDNLPRPLIYGLPPKRLYVHPDEQIDIIRAEKQLNQRVPQEPELEWVLPLHLAEKWSISDFAAVFDAITALPPGGESVNANEDAQWQLWRGPKRGKRILLATVQDDSTVTYYWMHNGLVKPRQN
What is the function of this protein?
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).
What are the official names of this protein?
Probable tRNA-splicing endonuclease subunit tsp-1, tRNA-intron endonuclease sen15, tRNA-splicing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SEN15 family.
Protein: COX2_PELSU
Sequence: MPTPNQTNFQDAASPLMEELTHFHDHTLMIVFMISLLVLYILLSMLSTKLTHTNTANAQQAEMVWTILPAIILITIALPSLQILYMMDEINKPHMTIKAIGHQWYWTYEYTDYKELEFNSYMIQTQDLPLGHMRLLEVDHRMVTPLESYIRMLISADDVLHSWAIPSLGLKTDAVPGRINQAVFIIMQAGIFYGQCSEICGANHSFMPVVVESLPMNHFDLWLAMIDTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CLCA_SALTI
Sequence: MKTDTSTFLAQQIVRLRRRDQIRRLMQRDKTPLAILFMAAVVGTLTGLVGVAFEKTVSWVQNMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPAAAGGGFNLIPIAAAGNFSVGLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHLEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQAAKNQNAPAGENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1382_METTH
Sequence: MIFMGSTETVLSVLVLVLLGYILKVLGVLGEEDASTLNRVVINVAIPSLIFTSLYRADLSGISDLVLIPVICMITGTLSGTIAYLWARRRGLDSGKTWGLTVAAAMMNSGFLGYPVTAGIFGSEGLVRAIFYDTGTTLMFTSLGLLLSHISGGEGSRIMKRAVFFPPLWAFLLGVIFNLWGLPTGIAGTILGYLSGAAVPLIMISLGLTLNFRFLRHSVADATLVSGLRLLISPLMAAGISYVLAFRGLNFSVTVLEASMPSAMLAAVLAIENDLDVDLVSSCIFMSTILSLVSLPLWSVVL
What are the official names of this protein?
Uncharacterized transporter MTH_1382.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLB3_ARATH
Sequence: MQSLQDKASVLSGVDQAEAFAIDESNLFDKLGLQTFINLSTNFYTRVYDDEEEWFQSIFSNSNKEDAIQNQYEFFVQRMGGPPLYSQRKGHPALIGRHRPFPVTHQAAERWLEHMQNALDDSVDIDQDSKIKMMKFFRHTAFFLVAGNELKNQNEKPKHKPQCACKHAANKPAEE
What is the function of this protein?
Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO.  May promote shoot organogenesis from root explants in vitro (PubMed:11526234, PubMed:21741261).  Inhibits RGLG3 and RGLG4 ubiquitination activity (PubMed:27497447).
What are the official names of this protein?
Two-on-two hemoglobin-3, AtGLB3, 2-on-2 hemoglobin-3.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group II subfamily.
Protein: SIX6_MOUSE
Sequence: MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGPGRVLRSEGEGTPEVLGVASSPAASLSSKAATSAISITSSDSECDI
What is the function of this protein?
May be involved in eye development.
What are the official names of this protein?
Homeobox protein SIX6, Optic homeobox 2, Sine oculis homeobox homolog 6, Six9 protein.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL9_STAA1
Sequence: MKVIFTQDVKGKGKKGEVKEVPVGYANNFLLKKNYAVEATPGNLKQLELQKKRAKQERQQEIEDAKALKETLSNIEVEVSAKTGEGGKLFGSVSTKQIAEALKAQHDIKIDKRKMDLPNGIHSLGYTNVPVKLDKEVEGTIRVHTVEQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NUDT4_HUMAN
Sequence: MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR
What is the function of this protein?
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170).  Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170).  Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170).  Does not play a role in U8 snoRNA decapping activity (By similarity).  Binds U8 snoRNA (By similarity).
What are the official names of this protein?
Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DIPP subfamily.
Protein: DDIT3_RAT
Sequence: MAAESLPFAFETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPAEVTSTSQSPRSPDSSQSSMAQEEEEEDQGRTRKRKQSGQCAARAGKQRMKEKEQENERKVAQLAEENERLKLEIERLTREVETTRRALIDRMVSLHQA
What is the function of this protein?
Multifunctional transcription factor in ER stress response.  Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress.  Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.  Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes.  Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.  Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG).  Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity.  Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.  Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity).
What are the official names of this protein?
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA-damage-inducible protein GADD153.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Protein: RNH2A_NEUCR
Sequence: MADIQDEAGPFLPPTISPPALLSGVSQTYFSPIPPQLLADNTPCCLGVDEAGRGPVLGPMVYSAFYLPLTLSDPLLKQKHSFDDSKVLTPAVRLSLMKELCTKDTELHDNCGYATSSLSPLSISSGMLKASKAQIYNLNQQAMDATIALIKGIYERGVNVTDIFIDTIGQPAAYQKKLERVFPTAKITVAKKADSLYPVVSAASVVAKVTRDIALEVLWADRTMAWGSGYPSDSKCVSWLKQNMHPVFGWGPECRFSWGTAKDMLETKGGVKVDWPEEEEEETQKLTDFFMAKRDQAEVDVDDLGTWFGAPAGVECF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.  Participates in DNA replication.
What are the official names of this protein?
Ribonuclease H2 subunit A, RNase H2 subunit A, Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. Eukaryotic subfamily.
Protein: ACH1_DROME
Sequence: MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKKFELLKMGSENTL
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit alpha-like 1, Nicotinic acetylcholine receptor alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: MRKB_KLEPN
Sequence: MKRIALFFCFIFSFAAHANNIIVNGTRFIYPGNEKEITVQLSNTADRPALATAWLDNGNADATPDTITTPFIITPPISRVDAKSGQTLRIKLGSNAGLAKDKETLWWLNLLEIPPVEASQKNEGQNILQLAIRSRFKFIYRPAGLGNRDAAAEKLALSANGSSLSVSNPTPFYITVSRISRNGGKALNSKTVMFAPQSSQTIALSSAVSKGETLTVNNINDYGADVAVKVTVK
What is the function of this protein?
Mediates assembly of pili by forming soluble multimeric complexes with pili subunits as an intermediate step in the assembly process.  This protein is involved in type 3 pili assembly.
What are the official names of this protein?
Chaperone protein MrkB.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.