PharMolix/UniProtQA huggingface dataset:
Protein: BTN1_CRYNB
Sequence: MDKDNQALDELPMMTGSKHANKRLFAAFMIFGLLNNVLYVIILSAALDLVSADTPKGVVALFNIFPALITKVVWPLLSNGKIRYTRRVGFCTICSWFGIITIALSSSLSPRLLGISLASLSSGMGELTFLQLTTTLPTEATSKTALGAWSSGTGFAGVAGAGIWWLLRGLGVKGGLGLSSFLPLFFPITYKYILPPFSHLEASSDSSPYQRLPTSSSLSNNNNFRPPAILISVPSSEYVPQHTPLLSSGFIDRDRDRNRDGEELTDGDKRLMGMRASRLTTQEKMKLLRPLVVRYMLPLCAVYVEEYVINSGVAPTLVFPLPTYGLWSWLFKSPRDYYPFWSLTYQTFVFLSRSSLSLGLPPIPKRLLPLPAIIQFLVLSLLFLQAKTFFFSSPAYTPPADGDGGVDRSITIVFLLICLEGLCGGSGYVNTFYHVGREGSSVSENYDADGENEMGGDRRTLNVTEMEKKAMEREFRIGAVGAADSTGILFASLISMPLEIALCRSQVDQGRTMCREL
What is the function of this protein?
Involved in vacuolar transport and vacuole pH homeostasis.  Also required for cytokinesis (By similarity).
What are the official names of this protein?
Protein BTN1.
What is the protein family that this protein belongs to?
Belongs to the battenin family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: E13B_PEA
Sequence: MASFFARTRRFSLVSLFLLELFTINLIPTTDAQIGICYGMMGNNLPPANEVIALYKANNIKRMRLYDPNQPALNALRDSGIELILGIPNSDLQTLATNQDSARQWVQRNVLNFYPSVKIKYIAVGNEVSPVGGSSWLAQYVLPATQNVYQAIRAQGLHDQIKVTTAIDMTLIGNSFPPSKGSFRSDVRSYLDPFIGYLVYAGAPLLVNVYPYFSHIGNPRDISLPYALFTSPGVMVQDGPNGYQNLFDAMLDSVHAALDNTGIGWVNVVVSESGWPSDGGSATSYDNARIYLDNLIRHVGKGTPRRPWATEAYLFAMFDENQKSPELEKHFGVFYPNKQKKYPFGFGGERRDGEIVEGDFNGTVSLKSDM
What is the function of this protein?
Implicated in the defense of plants against pathogens.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
Protein: VIME_HUMAN
Sequence: MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
What is the function of this protein?
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
What are the official names of this protein?
Vimentin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Cell membrane.
Protein: CAMK2_ARATH
Sequence: MGGCTSKPSSSVKPNPYAPKDAVLQNDDSTPAHPGKSPVRSSPAVKASPFFPFYTPSPARHRRNKSRDGGGGESKSVTSTPLRQLARAFHPPSPARHIRDVLRRRKEKKEAALPAARQQKEEEEREEVGLDKRFGFSKELQSRIELGEEIGRGHFGYTCSAKFKKGELKDQEVAVKVIPKSKMTSAISIEDVRREVKILRALSGHQNLVQFYDAFEDNANVYIVMELCGGGELLDRILARGGKYSEDDAKAVLIQILNVVAFCHLQGVVHRDLKPENFLYTSKEENSMLKVIDFGLSDFVRPDERLNDIVGSAYYVAPEVLHRSYTTEADVWSIGVIAYILLCGSRPFWARTESGIFRAVLKADPSFDEPPWPSLSFEAKDFVKRLLYKDPRKRMTASQALMHPWIAGYKKIDIPFDILIFKQIKAYLRSSSLRKAALMALSKTLTTDELLYLKAQFAHLAPNKNGLITLDSIRLALATNATEAMKESRIPDFLALLNGLQYKGMDFEEFCAASISVHQHESLDCWEQSIRHAYELFEMNGNRVIVIEELASELGVGSSIPVHTILNDWIRHTDGKLSFLGFVKLLHGVSTRQSLAKTR
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
CDPK-related kinase 2, AtCRK2, Calcium/calmodulin-dependent protein kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor; Cytoplasmic side.
Protein: GSHRC_ORYSJ
Sequence: MARKMLKDEEVEVAVTDGGSYDYDLFVIGAGSGGVRGSRTSASFGAKVAICELPFHPISSDWQGGHGGTCVIRGCVPKKILVYGSSFRGEFEDAKNFGWEINGDINFNWKRLLENKTQEIVRLNGVYQRILGNSGVTMIEGAGSLVDAHTVEVTKPDGSKQRYTAKHILIATGSRAQRVNIPGKELAITSDEALSLEELPKRAVILGGGYIAVEFASIWKGMGAHVDLFYRKELPLRGFDDEMRTVVASNLEGRGIRLHPGTNLSELSKTADGIKVVTDKGEEIIADVVLFATGRTPNSQRLNLEAAGVEVDNIGAIKVDDYSRTSVPNIWAVGDVTNRINLTPVALMEATCFSKTVFGGQPTKPDYRDVPCAVFSIPPLSVVGLSEQQALEEAKSDVLVYTSSFNPMKNSISKRQEKTVMKLVVDSETDKVLGASMCGPDAPEIIQGMAVALKCGATKATFDSTVGIHPSAAEEFVTMRTLTRRVSPSSKPKTNL
What is the function of this protein?
Maintains high levels of reduced glutathione in the cytosol.
What are the official names of this protein?
Glutathione reductase, cytosolic, GR, GRase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_SYNFM
Sequence: MGQKVHPTGFRLGILKSWDSRWFATKDYAKLVHEDRKIRDYIKARLYHAGIAKVEIERAANKVKIRIFTARPGIVIGKKGAEIETLRRDLERKFKREILIDIQEVRRPELDATLVGENISLQLVRRVAFRRAMKRAVSAALKFGAKGVRVASAGRLGGAEMARREWYREGRVPLHTLRADIDYGTAIARTTYGAIGVKVWIFKGEVLP
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SPRTL_STAA3
Sequence: MNNDKLQRMVENLSEEKFGRTFRHCAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKGYQHKDQDFKRLSQQVGAPRFCNSIESYQQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMIG3_MOUSE
Sequence: MEFLLLLSLALFSDAMVMDEKVKSGVELETASAVCVYDAYYKDHTKYWCRGYFRDSCNIIAFTPNSTNRVALKDTGNQLIITISCLVKEDTGWYWCGIQRDLARDDMDFTQLIVTDNREDRANGFSSDPSGNRTRSCRASKAVQKAEGSRMSILIICILITSLGIIFIISHLSRGRRSQRNREVTGKSISRNPQASQGPSMVSITLARI
What are the official names of this protein?
Transmembrane domain-containing protein TMIGD3.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: ISCS_PSEAB
Sequence: MKLPIYLDYSATTPVDPRVAQKMSECLLMDGNFGNPASRSHVFGWKAEEAVENARRQVAELVNADPREIVWTSGATESDNLAIKGVAHFYSGKGKHIITSKIEHKAVLDTCRQLEREGFEVTYLEPGEDGLITPALVEAALRDDTILVSVMHVNNEIGTVNDIAAIGELTRSRGVLFHVDAAQSTGKVEIDLDKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEGQMHGGGHERGMRSGTLATHQIVGMGEAFRIAKEEMAQENARVLALRDRFFAQIDGLEELYINGSMTSRVPHNLNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTFGRFTTEEEIDYAAKKVVEAVSKLRELSPLWDMYKEGVDLSQVEWQAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y767_METJA
Sequence: MVNVERISISFPKFLLKEIDEVVKKKGYSSRSELIRDAVRKYVLENNPLNKNETVSGIIIVVYNPTKEALEKMSKLYFEHNKVIKSLNQAYVTTSCGKNAKVEIFVVEGNSKDISKFYEEIEKINGKIYDKVIIF
What are the official names of this protein?
Uncharacterized transcriptional regulator MJ0767.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: RNFE_BUCBP
Sequence: MSNILKIFVDGLWKKNSSLVQLLGLCPVLAITVNAINAIGLGLATTLVLICSNATISLIKNNIQKDFRIPIYIIIISSVVSSIDLVIKAYAFNLYQSLGIFIPLIITNCIVCNRADLIAVHNSVLVSILDGLSIGLGSTLTMFLLGSIREIIGHGTLFFGIEHVLGESFRFLYIEVLDKNSVFLLFAFPSGAFMILGIVLAGKNFLDEVLGIIEHKNVCVCSNKVLVYKDGNKKIESQKSL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CM3A_CONSE
Sequence: PLFDKRQRCCNGRRGCSSRWCRDHSRCCGRR
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  This toxin blocks rNav1. 5/SCN5A (IC(50) is 1. 3 uM), rNav1. 6/SCN8A (IC(50) is 160 nM), rNav1. 7/SCN9A (IC(50) is 1. 3 uM), rNav1. 1/SCN1A (K(d) is 3. 8 nM), rNav1. 2/SCN2A (K(d) is 1. 3 nM), rNav1. 4/SCN4A (K(d) is 0. 22 nM), rNav1. 6/SCN8A (K(d) is 69 nM), and rNav1. 7/SCN9A (K(d) is 260 nM).  This toxin is very potent but weakly discriminating among sodium channels.  The block of these channels is modified when beta-subunits are coexpressed with alpha subunits.  Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits).
What are the official names of this protein?
Mu-conotoxin SmIIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CHSA_SOLTU
Sequence: MVTVEEYRKAQRAEGPATILAIGTSTPSNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCDKSMIKKRYMHLTEEILKENPNMCAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGCDYQLAKLLGLRPSVKRLMMYQQGCFVGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIMGSDPIIGVERPLFELVSAAQTLVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLLEAFQPLGISDWNSLFWIAHPGGPAILDQVELKLGLKQEKLRATREVLSNYGNMSSACVLFILDEMRKASTNEGLGTTGEGLEWGVLFGFGPGLTVETVVLHSVAT
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 1A, Naringenin-chalcone synthase 1A.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: XISA_NOSS1
Sequence: MQNQGQDKYQQAFADLEPLSSTDGSFLGSSLQAQQQREHMRTKVLQDLDKVNLRLKSAKTKVSVRESNGSLQLRATLPIKPGDKDTNGTGRKQYNLSLNIPANLDGLKTAEEEAYELGKLIARKTFEWNDKYLGKEATKKDSQTIGDLLEKFAEEYFKTHKRTTKSEHTFFYYFSRTQRYTNSKDLATAENLINSIEQIDKEWARYNAARAISAFCITFNIEIDLSQYSKMPDRNSRNIPTDAEILSGITKFEDYLVTRGNQVNEDVKDSWQLWRWTYGMLAVFGLRPREIFINPNIDWWLSKENIDLTWKVDKECKTGERQALPLHKEWIDEFDLRNPKYLEMLATAISKKDKTNHAEITALTQRISWWFRKVELDFKPYDLRHAWAIRAHILGIPIKAAADNLGHSMQVHTQTYQRWFSLDMRKLAINQALTKRNEFEVIREENAKLQIENERLRMEIEKLKMEIAYKNS
What is the function of this protein?
Essential for DNA excision.  Site specific recombinase necessary for the excision of the 11 kb nifD element during heterocyst differentiation.
What are the official names of this protein?
Excisase A, NifD element site-specific recombinase.
What is the protein family that this protein belongs to?
Belongs to the XisA/XisC recombinase family.
Protein: URE31_BRUAB
Sequence: MNLTPREKDKLLIAMAAMVARRRLERGVKLNHPEAIALVSDFVVEGARDGRTVAELMEAGAHVITREQVMDGVAEMIRDIQVEATFPDGTKLVTVHEPIR
What are the official names of this protein?
Urease subunit gamma 1, Urea amidohydrolase subunit gamma 1.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_VIBVU
Sequence: MALTKADLAENLFEKLGFSKRDAKDTVEVFFEEIRKALENGEQVKLSGFGNFDLRDKNERPGRNPKTGEDIPITARRVVTFRPGQKLKARVENLK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: CPFC_MYCSS
Sequence: MLFDALLVLSFGGPEGPDQVMPFLENVTRGRGIPRERLASVAEHYLHFGGVSPINGINRALIAEIEAELGDRGETLPVYFGNRNWDPYVEDAVTAMRDDGVRRAAVFATSAWGGYSSCTQYNEDIARGRAAAGDGAPQLVKLRHYFDHPLLVEMFAESISVAAQSLPADVRDEARLVFTAHSIPVAADDRHGPNLYSRQVAYATRLVAAAAGYSEFDQVWQSRSGPPRIPWLEPDIGDHVTALAERGTKAVIICPIGFVADHIEVVWDLDSEVREQAADLGIAMARARTPNADRRYARLALDLVDELRGDRDPLRVAGVDPAPGCGYSVDGTTCADSPRCVARITG
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMTA2_ORYLA
Sequence: MAGNLLRGPPLLLRAADKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPNYEVFGSVSSESNSESSIPKYELFPKSQLSSSTPPQQSGGKPVSAESDSAPGISSPDARHEGGSGSENGDSESFINSPVSKPLKDGEETPGSVSSLGSDSGSEIDKDEQEPSPSSVASRHMNAIDILTRVFPSHKRSVLELVLQGCGKDVVQAIEQILNNGGAQAPKAGAEETWTAERMLQSAQQLPAASATTAPSSRPMLPGAMALSNRSAFSPLQPNAPHFGADPGSYPLGTHLGLNPLRLAYSAHSRGLAFMTPYSTTGLMPTLGFRPPMDYAFSDLIRDRTMLHKEQPYASGLYGPLVNNTPDKQ
What is the function of this protein?
May be involved in sexual development.
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor A2, Doublesex- and mab-3-related transcription factor 5, Ola-DMRT5.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPD_STRCO
Sequence: MSGMHGASREALAAARERLDALTDSTSVDAGSLADELAAVTALLHREVSLRRVLTDPAQSGEAKAELAQRLLGTQVSGTAVDLVAGTVRSRWSQSRDLVDALEQLANIADLTAAQKRGRLDNVEDELFRFGRIISSNTELRAALTSRSATTAAKSELLAGLLGSRAERTTERLVTRLVTAPRGRSLESGLESLSKLAADRRDRMVAVVTSAVPLSDTQKQRLGAALAKVYGRPMHLNLDVDPEVLGGIRVQVGDEVINGSIADRLEDAGRRLAS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FADR_SHIDS
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_NOSS1
Sequence: MPLSDAMPALLVLADGTAYRGWSFGATGTTIGEVVFNTGMTGYQEVLTDPSYRGQIVVFTYPELGNTGVNPEDEESARPQVRGAIARNICHKPSNWRSTQSLPDYLKQHHIPGIFGIDTRALTRKIRMYGAMNGGISTEILDEAELLEQVQAAPNMAGLNLVREVTTSTVYEWSDPTTAVWEFNPDGTVKNGESLTVVALDFGVKRNILRRLASYGCRVIVVPADTSPEEILKYNPDGIFLSNGPGDPSAVTEGITTAKALLESEKPIFGICMGHQILGHALGAETFKLKFGHRGLNQPAGLTQRVEITSQNHSFAIDPDSLPEAVVEISHLNLNDRTVAGLRHKSLPIFSVQYHPEASPGPHDADYLFAQFVHQMRTTKQATTAEVS
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: MK09_RAT
Sequence: MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSINDISSMSTEHTLASDTDSSLDASTGPLEGCR
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death.  Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2.  In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity.  In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3.  Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1.  In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells.  Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels.  Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption.  When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway.  Participates also in neurite growth in spiral ganglion neurons.  Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock.  Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation.
What are the official names of this protein?
Mitogen-activated protein kinase 9, MAP kinase 9, MAPK 9, SAPK-alpha, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, p54-alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Colocalizes with POU5F1 in the nucleus.
Protein: THF1_PROM4
Sequence: MRQRLTVSESKAIFHKEFPFVVPAVYRRLVDELIVELNLLKNQERFVADGVFAIGLTSIFLDFTKGYKPENQKGILLEAICKCTGFSASNLEQIALEAKKLANGLNTNEIKSLITDNNRDEKESTYKLINKNNHYSRIIAIGIYKLVDMQSNGFNKEEATENSYLDLVNNFGYTKERVEKDVNLYKSSLDKIEKALELIEMNIKDEKRRNKERVSRTKPGQ
What is the function of this protein?
May be involved in photosynthetic membrane biogenesis.
What are the official names of this protein?
Protein Thf1.
What is the protein family that this protein belongs to?
Belongs to the THF1 family.
Protein: RL18_MYCUA
Sequence: MGQSVSAIRRVSRLRRHARLRKRIAGTQQRPRLVVHRSARHIHVQLVNDANGTTVAAASSIETDVRGLDGDKKARSVRVGQLIAERAKAADIDTVVFDRGGYTYGGRIAALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RK33_PHATC
Sequence: MAKNKGTRILITLECTECRSNLEKRSPGVSRYSTQKNRRNNPERLELKKYCSHCNKTTLHKEIK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL13_ORITB
Sequence: MKTYSAKPAEISKKWILIDATNLVLGRLAAKVAVVLRGKDKPTYTPHMDCGNNVIIINAEHVKLTGDKSNAKSGKFYYRHSGFPGGIKVTTAGKILQSNYPERIIQLAVKRMLPSNKLGRKQFSNLYVYKGQTHPHAAQTPVLYDFAGKNSKNIRNQNIV
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y34B_LACJO
Sequence: MEDKHGIKDKVAGKLKEVEGKITGDKAREVEGKAQQAKGKVKSKATEVKEDLE
What are the official names of this protein?
UPF0337 protein LJ_0034.1.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: PGK_STRSV
Sequence: MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRFEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISGNVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLVLPVDSKEANAFADYTEVKDTEGEAVDPGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_BURL3
Sequence: MTTLSPDAFAGHTPMMQQYLRIKADHPDTLVFYRMGDFYELFFEDAAKAARLLDLTLTQRGASAGTPIKMAGVPHHAVEQYLAKLVKMGESVAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKNDVYLLAMCTGHNKRGVAVNIGLAWLNLASGALRLAEIEPDQLAAALERIRPAEILTPDGATDAVPAGAGASKRVPAWHFDIASGTQRLCDQLDVASLDGFGAHSLTSACGAAGALLLYAAATQGQQLRHVRSLKVENETEYIGLDPATRRNLELTETLRGTESPTLYSLLDTCCTTMGSRLLRHWLHHPPRASVAAQSRQQAIGALLDAPANASLDALRSALRQIADVERITGRLALLSARPRDLSSLRDTFAALPALRERISAIVANADSLTRVDAALAPPAECLDLLTSAIAPEPAAMVRDGGVIARGYDAELDELRDISENCGQFLIDLEARERTRTGIANLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALARERALYDAVLQALLPFIPECQRVASALAELDLLAAFAERASALDWVAPTFTDEIGIEIEQGRHPVVEAQVEQFIANDCRFGTERKLLLITGPNMGGKSTFMRQTALIALMAYVGSYVPAKSACFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPQSLVLMDEIGRGTSTFDGLALAWAIARHLLAHNACYTLFATHYFELTQLPAEFPQAANVHLSAVEHGHGIVFLHAVNEGPANQSYGLQVAQLAGVPAPVIRAARKHLAYLEQQSASQHTPQLDLFSAPPVAADDLECADAPALPDTPHPALEKLRDIDPDDLKPREALDLLYELRTLVRSHDADGHA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RSMC_YERP3
Sequence: MSALTPASEVILRHSDEFIARHVLFAGDLQDALPAQFDAAGVRVHTNQYHHWQLLSNTLEENVQFGLLATAETLAACDTLIYYWPKSKQEAQFQLANLLSILPVGTDIFVVGENRSGVRSAEEMLADFAQLAKIDSARRCGLYHGRLDKQPEFDADAWWESYQVGGVTVKTLPGVFSRDSLDSGSHLLLSTFNEPFKGSVLDVGCGAGVLASVLAQQSPKIKWTLSDVSAAAIEASRATLAVNNIEAQVIASNVYSDIKGRFEMIISNPPFHDGIQTSLTAAEMLIRGATAHLHVGGKLRIVANSFLPYPALLDAAFGSHEVLAQNGRFKVYQATVGRPPRDPKKKR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A6477_ARTBC
Sequence: MRSVLYLLFTAVAAVAALENPFLVPPGGYQFNTREPTVLNWQPTTPGTVTLKLQMSSDITPHSGLVLAAHLENTGTFTFLPPPDLMQNGLYTVQIIDDNDPSKYNFTPSFMVDGATGGPTTGPTTSRTSMTTSEATTTSGESTTSPSSTRPSTVSPTTTDSSDTTMSTVTSSSTPTTTDSTTTSESTAVSSTRSSSTGMPTSSGAPDPNGAVSLALPGGLLSIVLSLMALL
What is the function of this protein?
Probable component of the cell wall.
What are the official names of this protein?
Probable cell wall protein ARB_06477.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Secreted. Secreted, cell wall.