PharMolix/UniProtQA huggingface dataset:
Protein: MCP_HHV6U
Sequence: MENWQATEILPKIEAPLNIFNDIKTYTAEQLFDNLRIYFGDDPSRYNISFEALLGIYCNKIEWINFFTTPIAVAANVIRFNDVSRMTLGKVLFFIQLPRVATGNDVTASKETTIMVAKHSEKHPINISFDLSAACLEHLENTFKNTVIDQILNINALHTVLRSLKNSADSLERGLIHAFMQTLLRKSPPQFIVLTMNENKVHNKQALSRVQRSNMFQSLKNRLLTSLFFLNRNNNISYIYRILNDMMESVTESILNDTNNYTSKENVPLDGVLLGPIGSIQKLTSILSQYISTQVVSAPISYGHFIMGKENAVTAIAYRAIMADFTQFTVNAGTEQQDTNNKSEIFDKSRAYADLKLNTLKLGDKLVAFDHLHKVYKNTDVNDPLEQSLQLTFFFPLGIYIPSETGFSTMETRVKLNDTMENNLPTSVFFHNKDQVVQRIDFADILPSVCHPIVHDSTIVERLMKSEPLPTGHRFSQLCQLKITRENPARILQTLYNLYESRQEVPKNTNVLKNELNIEDFYKPDNPTLPTERHPFFDLTYIQKNRATEVLCTPRIMIGNIPLPLAPVSFHEARTNQILEHAKTNCQKYDFTLKIVTESLTSGSYPELAYVIETLVHGNKHAFMILKQVISQCISYWFNMKHILLFCNSFEMIMLISNHMGDELIPGAAFAHYRNLVSLIRLVKRTISISNLNEQLCGEPLVNFANALFDGRLFCPFVHTMPRNDTNAKITADDTPLTQNTVRVRNYEISDVQRMNLIDSSVVFTDNDRPSNETTILSKIFYFCVLPALSNNKACGAGVNVKELVLDLFYTEPFISPDDYFQENPITSDVLMSLIREGMGPGYTVANTSCIAKQLFKSLIYINENTKILEVEVSLDPAQRHGNSVHFQSLQHILYNGLCLISPITTLRRYYQPIPFHRFFSDPGICGTMNADIQVFLNTFPHCQRNDGGFPLPPPLALEFYNWQRTPFSVYSAFCPNSLLSIMTLAAMHSKLSPVAIAIQSKNKIHPGFAATLVRTDNFDVECLLYSSRAATSIILDDPTVTAEAKDIATTYNFTQHLSFVDMGLGFSSTTATANLKRIKSDMGSKIQNLFSAFPIHAFTNADINTWIRHHVGIEKPNPSESEALNIITFGGINKNPPSILLHGQQAICEVILTPVTTNINFFKSPHNPRGRESCMMGTDPHNEEAARKALYDHTQTDSDTFAATTNPWASLPGSLGDILYNTAHREQLCYNPKTYSPNAQFFTESDILKTNKMMYKVISEYCMKSNSCLNSDSEIQYSCSEGTDSFVSRPCQFLQNALPLHCSSNQALLESRSKTGNTQISETHYCNYAIGETIPFQLIIESSI
What is the function of this protein?
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers).  Hexons form the edges and faces of the capsid and are each composed of six MCP molecules.  In contrast, one penton is found at each of the 12 vertices.  Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex.  The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.
What are the official names of this protein?
Major capsid protein, MCP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: MURQ_PHOPR
Sequence: MKIDLTNLITESRNTASQHIDTLSTIDMLKVINDEDKKVALAVEKTLPEISQVVDAITEAFKKGGRLIYTGAGTSGRLGILDASECPPTYGSKPEQVVGLIAGGHTAILRAVENAEDNRELGEGDLKGLNFNEKDVLVGIAASGRTPYVLGAMAYAKSVNATVACISCNPNSPMTAAADISITPVVGAEVVTGSSRMKAGTAQKLVLNMLTTGAMIRSGKVFGNLMVDVEATNAKLVERQKKIVIEATDCSREEAESALAACNGHCKTAIVMVLAQLSAEEAKQLLDNNKGFIRAAIAAGK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: SYVM_HUMAN
Sequence: MPHLPLASFRPPFWGLRHSRGLPRFHSVSTQSEPHGSPISRRNREAKQKRLREKQATLEAEIAGESKSPAESIKAWRPKELVLYEIPTKPGEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKPEYQARLPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDWLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAQGEEDCWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRFTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSACSLEHWRQPELERRFSRVQEVVQVLRALRATYQLTKARPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPPGAAAPSGWAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSEGEAGTQRQQKLSSLQLELSKLDKAASHLRQLMDEPPAPGSPEL
What are the official names of this protein?
Valine--tRNA ligase, mitochondrial, Valyl-tRNA synthetase, ValRS, Valyl-tRNA synthetase-like.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PPIE_DROME
Sequence: MSNDKRTIYVGGLADEVTERLLNNAFIPFGDIADIQMPADYESQRHRGFAFIEYEQSEDAAAAIDNMNDSELCGRTIRVNLAKPVRVKEDSFKPIWADDDWLQKHAGATLQPEGEPEAEKVETPSTGPAVIEKAEKRNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKGCSFHRVIPEFMCQGGDFTNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFICTTKTDWLDNKHVVFGHVISGAEVVRKMERCGSKSGTPSQKIVIYSCGELK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Combines RNA-binding and PPIase activities (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase E, PPIase E, Cyclophilin 33, Cyclophilin E, Rotamase E.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS11_CAMJ8
Sequence: MAKRKIVKKKVVKKNIAKGIVYISATFNNTMVTVTDEMGNAIAWSSAGGLGFKGSKKSTPYAAQQAVEDALNKAKEHGIKEVGIKVQGPGSGRETAVKSVGAMEGIKVTFLKDITPLAHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LPT_YERPN
Sequence: MRYISLNTTIITTTETTGYGAG
What is the function of this protein?
This protein is involved in control of the biosynthesis of threonine.
What are the official names of this protein?
thr operon leader peptide, thr operon attenuator.
What is the protein family that this protein belongs to?
Belongs to the thr operon leader peptide family.
Protein: NRDR_CLOBL
Sequence: MKCPYCAYGESKVVDSRSTEDGSSIRRRRECLKCNRRYTTYEKIETTPILVIKKNMSREYFDRNKIVNGLMKACQKRPVSRKQIEQIANEVERHISNEMLTEVNTDKIGQIIMKNLKKIDEVSYVRFASVYRQFKDINTFMEEIKNLMDKN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ASXL1_MOUSE
Sequence: MKDKQKRKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNAATVDGDEPEDSADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSHRASSQANKQKKRTGVMLPRVVLTPLKVNGAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSAIRGQAEVTRDPAPLLRGFRKPATGQMKRNRGEEVDFETPGSILVNTNLRALINSRTFHALPLHFQQQLLLLLPEVDRQVGTDGLLRLSGSALNNEFFTHAAQSWRERLADGEFTHEMQVRLRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQKEVQEEAKVKSGLCVSGESVRPQRGPNTRQRDGHFKKRSRPDLRTRSRRNIYKKQEPEQAGVAKDASAAPDVSLSKDTKTDLAGVNSTPGPDVSSATSGQEGPKCPSEPVASQIQAERDNLACASASPDRIPTLPQDTVDQETKDQKRKSFEQEASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVAKGRPTYQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNRETATTAIGGGGGPGGGGSGAIDEGGGRDSSSGDGSEACGHPEPRGAPSTSGESASDLQRTQLLPPCPLNGEHTPAEAAMPRARREDSASLRKEESCLLKRVPGVLTSGLEDASQPPIAPTGDQPCQALPPLSSQTPVAEMLTEQPKLLLDDRTECESSREDQGPTIPSESSSGRFPLGDLLGGGSDQAFDNMKEPVSMTPTFISELSLANYLQDRPDDDGLGLGATGLLIRESSRQEALTEAFASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDEKEWERAVPLIAATESVPQPESCISHWTPPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHSESTDTASDSEGHLSEDSSEVDASEVTVVKGSLGGDEKQDWDPSASLSKVNNDLSVLTRTGGVAASQSWVSRVCSVPHKIPDSLLLSSTECQPRSVCPLRPGSSVEVTNPLVMHLLHGNLPLEKVLPPGHRSSRLESSQLPLREQSQDRGTLQGTGENNRLAARINPGSAQTLKESILAQSYGASAGLVRAMASKAPAMSQKIAKMVTSLDSQHPETELTPSSGNLEEIDSKEHLSSFLCEEQKEGHSLSQGSDPGAAPGQCLGDHTTSKVPCFSSTNVSLSFGSEQTDGTLSDQNNAGGHEKKLFGPGNTVTTLQCPRSEEQTPLPAEVPPVFPSRKIEPSKNSVSGGVQTTRENRMPKPPPVSADSIKTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKGFSQPLEPSSIPSQLNIKQALYGKLSKLQLSPTSFNYSSSSATFPKGLAGGVVQLSHKASFGTGHTASLSLQMFADSSAVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR
What is the function of this protein?
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617).  Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617).  Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (PubMed:21047783).  Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).  Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (By similarity).
What are the official names of this protein?
Polycomb group protein ASXL1, Additional sex combs-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the Asx family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HPPK_PSEAE
Sequence: MIQRVYVALGSNLAEPREQIQAALDAFERLPETRLVAVSPLYISDPLGPADQPRFVNGVAALDTNLAPLDLLDALQAIELEQGRVRDLRWGPRTLDLDILLFGEQLLDLPRLKVPHYHMQARAFVLYPLADLAPDLRLPDGRHLPELLAACPFEGIERLPGA
What is the function of this protein?
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
What are the official names of this protein?
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
What is the protein family that this protein belongs to?
Belongs to the HPPK family.
Protein: HVM56_MOUSE
Sequence: EVKLVESGGGLVKPGGSLKLSCAASGFTFSSYAMSWVRQTPEKRLEWVASISSGGSTYYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCAR
What are the official names of this protein?
Ig heavy chain V region 914.
Protein: PPK5_SUPLO
Sequence: GGGSSGETNGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, FXPRL-amide, SupLo-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIB_ECOBW
Sequence: MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGMMVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQHSVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VRK3_HUMAN
Sequence: MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP
What is the function of this protein?
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.
What are the official names of this protein?
Inactive serine/threonine-protein kinase VRK3, Serine/threonine-protein pseudokinase VRK3, Vaccinia-related kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KITH_LACAC
Sequence: MAQLFFRYGAMSSGKTIEILKVAHNYEAQGRKIALMTSGLDNRSGVGTVASRIGIHRKAIPITEEMDLFEYIKEMNNHDLADGDGKLACVLIDEAQFLKRHHVLECAKIVDEFNIPVMTFGLKNDFQNHLFEGSENLLIFADKIEEMKTICHYCGHKATMNLRINNGKPVYEGEQVQIGGDESYYPVCRYHYFHPNVVR
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_THEP1
Sequence: METQGVMKEIQYEEFEEKIIEIRRTSKVTKGGKNLSFRVVAIVGNKNGKVGLGIGKAREVPEAIRKAISAAKRNIIEVPVINGTIPHEIIGRQDASKVLLRPAAPGTGIIAGGTVRAVVELAGIQNILTKSLGSTNPLNLALATMNGLKNLLDPRKVAKLRDISVEEVFKGVRREDNA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LCFB_BACSU
Sequence: MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQEAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAIVGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAKQNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPMFHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHENGKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRKPGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWLYTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQSGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALRDILPQ
What is the function of this protein?
Involved in the degradation of long-chain fatty acids.
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase, Long-chain acyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: THIC_RUEST
Sequence: MNTPTRHPTPNVTTGALPASRKIYVAGEMHEGIRVPMREIATHPTAGEAPLPVYDSSGPYTDPDVSTDIREGLAPLRAAWIKARCDVEAYSGRDVTAADNGFVEGDRLVPEFPVKPAPLRGRQRAAPTQLAYARAGIITPEMEFVAIRENQLRDLSPCHCARDGEDFGANIPDYVTPEFVRAEIAAGRAIIPANINHPELEPMIIGRNFKVKINANMGTSSVTSSMEEEVDKLVWAIRWGADTVMDLSTGRNIHNTREWIIRNSPVPIGTVPIYQALEKVNGIAEDLTWEVFRDTLIEQAEQGVDYFTIHAGVRLHMVPMTVERVTGIVSRGGSIMAKWCLHHHRESFLYEHFEEICDICRQYDVSFSLGDGLRPGSIADANDAAQFAELETLGELTKIAWAKDCQVMIEGPGHVAMHKIKENMDKQLECCHEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPDRDDVKTGVITYKIAAHAADLAKGLPGAQRRDDALSRARFEFRWEDQFNLSLDPETAQSFHDETLPKEAHKVAHFCSMCGPKFCSMRISHDIRAEAQKEGFEAMAAKFREGGELYVPLKDTAPEEA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RLMF_SALHS
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQTFRRQVLWFTTLVSRGENLPPLYRALTEAGAVKVVKKEMAQGQKQSRFIAWTFMGDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUND_ASPNA
Sequence: MDDRLSSQLERYASQVTASATLIIRHLKSLKDEPSTLPSQTSVPTAVGTAQLRLAEAAFQLLHFTRDPGNVLTQLTVDLQVISAVRWLLHFEIFSLVPLEGSISYHELSSVANVPENLLRSHIRLAMTCHLFQESGPIGMVAHSPVSCQLASDPSLVSWGQYFANSVFPTATKNVNATAAWPGSKALNETAHNLAFNHHGSFFDYVSQDPARTVEFANSMKAVSTTSLFDTCHLCKSFDWSSLGDGVVVDMGGSTGHVSIALAESFPSLRFVVQDLPDVVSNSIRQLEERQLPLSVTTRIQFQGHSLLHMQPVKGAAVYLLRQILHDWPDREAVQILRSIVPALGPRSKIFIADIVLPEAGSIPATEEQVMRCNDLLLHQFTNTLERTLEDWQAIVSRVSDNLRIQHVYRDPGSILSLLVIETV
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurasperone B, a dimeric gamma-naphthopyrone (PubMed:31067027).  The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).  YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable).  A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B (PubMed:31067027).  AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A (PubMed:31067027).
What are the official names of this protein?
O-methyltransferase aunD, Aurasperone B biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: RECX_ACIF2
Sequence: MTTERSDPTALALRLLARREYGRRELGDKLLRAGCDAGDVALALDALAAAGYQDDARYVEMLTRTRVRQGHGPLRLRQDLQRAGIEVGADPEIDWLQQAQAVCRKRFGNTPPADARDYARRARFLAGRGFTGETIRQVLGAGRERDFAAD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_ANAPZ
Sequence: MEVNIVNIANEVVGSIDLNPQVFGLEPRRDVLKEVVNWQLAKRRAGTHKAKGISDISGTTAKPYRQKHTGRARQGSLRSPQFRGGAVIFGPVPRSHEYSLNKKVRRLGLKVALSMKVAANKLVVLDSLDVDLKKTADAKGVFGNFAGHSSYLVVSESCKEEVVRACRNLRGVDLLKCVGINVLDILKHDCVILTVDTVKSLEGRLSNE
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HEM6_XANAC
Sequence: MNEFDRVRDYLTDLQDRICAAVEAADGKARFAEDLWKREEGGGGRTRILRDGAVFEQAGIGFSDVSGTRLPPSASAHRPELAGATWRACGVSLVFHPHNPYIPTTHMNVRYFRAERDGEVVAAWFGGGFDLTPFYPFDEDVQHWHRVAQALCVPFGQERYAAHKRWCDEYFFLRHRNETRGVGGLFFDDLGQDFERDFAYQRAVGDGFLDAYIPIVQRRKDTPYGEREREFQLYRRGRYVEFNLVYDRGTLFGLQSGGRAESILMSLPPRVRWEYGFTPEPGSAEARLADYLIPRDWLG
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP8_ASPAM
Sequence: MPQLVPFFFVNQVVYAFVILTVLIYAFTKFILPKFVRIFISRIYINKL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: TAF8_HUMAN
Sequence: MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEENIIDNPYLRPVKKPKIRRKKSLS
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).  The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473).  TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473).  Mediates both basal and activator-dependent transcription (PubMed:14580349).  Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349).  Required for the integration of TAF10 in the TAF complex (PubMed:14580349).  May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43.
What is the protein family that this protein belongs to?
Belongs to the TAF8 family.
Protein: RL7_ENTFA
Sequence: MALNIENIVAELETATILELSELVKAIEEKFDVSAAAPVAVAGPAAGGAAEEQTEFTVELTAAGDQKVKVIKAVREATGLGLKEAKAVVDGAPAPVKEAVSKEEAEALKAALEEVGASVTVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.