PharMolix/UniProtQA huggingface dataset:
Protein: OBRG_PIG
Sequence: MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLVFHALSPIPHFIAKRATYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW
What is the function of this protein?
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP.  Negatively regulates growth hormone (GH) receptor cell surface expression in liver.  May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).
What are the official names of this protein?
Leptin receptor gene-related protein, Endospanin-1, OB-R gene-related protein, OB-RGRP.
What is the protein family that this protein belongs to?
Belongs to the OB-RGRP/VPS55 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Endosome membrane.
Protein: CBIM_PROFC
Sequence: MHIAEGVLPPVQCAIWFAAAAPFVVHGAVQVVKQIKHHPENRLLLATAGACTFLLSSIKLPSVTGSSSHPTGTGVGAVLFKPPVMAFMGLIVLIFQALLLAHGGITTLGANTFSMAIVGPWVGYGAYVLNKKLGGPLALGIFLAMFLSDLSTYCVTSFQLAFAYPDPSSGVLGAAEKFLGIFAISQIPLSVAEGILGILLFRFLFKVAGPQLQALGVRIGNKRTANAEVPEVAHV
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiM, Energy-coupling factor transporter probable substrate-capture protein CbiM, ECF transporter S component CbiM.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: M1_I57A1
Sequence: MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVITTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKSDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: EFTS_STAA3
Sequence: MATISAKLVKELREKTGAGMMDCKKALTETDGDIDKAIDYLREKGIAKAAKKADRIAAEGLVHVETKGNDAVIVEINSETDFVARNEGFQELVKEIANQVLDTKAETVEALMETTLPNGKSVDERIKEAISTIGEKLSVRRFAIRTKTDNDAFGAYLHMGGRIGVLTVVEGSTDEEAARDVAMHIAAINPKYVSSEQVSEEEINHEREVLKQQALNEGKPENIVEKMVEGRLRKYLQEICAVDQDFVKNPDVTVEAFLKTKGGKLVDFVRYEVGEGMEKREENFADEVKGQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_ACTP7
Sequence: MNILISNDDGYHAQGIQTLAETLRDAGHSVTVIAPDRNRSAASSCLTLMEPIRVHQLDEFNYAVIAGTPADCVHLALNGFFEQSFDLVISGINHGANLGDDVVYSGTVAAALEGRHLPYPSLAISLVGRKSEGHLFGNNHFDTAAKVVLDLLPKVQKGIVPARQILNINVPDLPYEQVKGVMITRLGHRSPAAEIVKREDPRGATIYWLGANGVPVDASEGTDFYALAHNYVSVTPIQADMTAHYSIQALKDTF
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INH4_TABYA
Sequence: MTLNVYFVLLSPYSLQSVPLPLTMQVIVPRRGDHVGCRNAGFGAHCGSNPQTPKLHQEHIKMVLQKTNWLRGVVAEGSFCYPKAARMPVLVWDDDLANLASLHTKGCVTETNKCRSTERFRSPGQSSYEISGDTLPSAMDILNFALRDWYLQKDNLTRKDIGSYPAGEDKGLKNMANLISDKVTAIGCGLTHWEEGKLKRALFTCNFSSSNVPGHPIYQRGDNFATKCAKTHPYYKSLCNSDEHIKPNK
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (PubMed:19531497).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
What are the official names of this protein?
Tabinhibitin 4.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: FLII_BUCAP
Sequence: MEGTMSSCFRGMLMKLRFSELLNNISSFEKKVNNLSDIFSYGCLISVNGLLLEVIGLTAPIGSRCYVERIIDGKILNISAEVVGFKKEKTLLFSLEETYGVFPGTRVFLKCFKNTYSITGKIPLSTELLGRVLDSKGRPLDGRSQLNPKFFTFLKSNVVNPLNRKPITEVLDTGIRAINALITVGRGQRIGIFSSSGLGKSILLGMMAKYTKADVVIIGLIGERGREVKDFIENILGSNGLSRSVVIAAPADVSPLLQIEAASYATSIAEYFRKKNKHVLLIMDSLTRYAMAQRAVSLSLGELPVSKGYPSSVFSKIPILVERTGNTDNYGSITSFYTVLTESEEDPQDPIAHICRSILDGHIVLSRHYAELGHYPAIDIENSISRVMPNIISKKQYSQACYFKKLIASYQRNRDLINIGAYLKGTDSTLDHAIKIWPILERFLQQKQSEKSSYLSSCEELNQIFI
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.  May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage (By similarity).
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDPK6_ARATH
Sequence: MGNSCRGSFKDKIYEGNHSRPEENSKSTTTTVSSVHSPTTDQDFSKQNTNPALVIPVKEPIMRRNVDNQSYYVLGHKTPNIRDLYTLSRKLGQGQFGTTYLCTDIATGVDYACKSISKRKLISKEDVEDVRREIQIMHHLAGHKNIVTIKGAYEDPLYVHIVMELCAGGELFDRIIHRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFKDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGYIDFDTDPWPVISDSAKDLIRKMLCSSPSERLTAHEVLRHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKKMALKVIAESLSEEEIAGLRAMFEAMDTDNSGAITFDELKAGLRRYGSTLKDTEIRDLMEAADVDNSGTIDYSEFIAATIHLNKLEREEHLVSAFQYFDKDGSGYITIDELQQSCIEHGMTDVFLEDIIKEVDQDNDGRIDYEEFVAMMQKGNAGVGRRTMKNSLNISMRDV
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.  Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure (PubMed:17032064).  Phosphorylates FD (PubMed:25661797).
What are the official names of this protein?
Calcium-dependent protein kinase 6, Calcium-dependent protein kinase isoform CDPK3, AtCDPK3, Calmodulin-domain protein kinase CDPK isoform 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Nucleus.
Protein: Y1330_DEIRA
Sequence: MGTEEPARKFYTAPMTRYAEVAAFTTVPGQGNRAGVVLDAGELTGEQMQRLAAFLEAPETVFVTRLSDGLGRVRYFTPTQEVDFCGHATVALGRVLAQAGRWRGEALELETLAGRIPLRLVLDAGGGECRVWMHQPAFGTRAVGRGWHRELAEALGLSDRLLHRGLPLAAASTGLWSVFLPLLDASLLEGLEPDLPRIAELSRELGVVSVYAYAPVGVNRFAARDFAPLVGIPEDPVTGSAGGALLALLASEGRLPLRGNRASGLIYQGHALGTPGEIEVEVEVRGTRVEAVQVGGCAAVEREGVWPG
What are the official names of this protein?
Uncharacterized isomerase DR_1330.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: IHFB_ACTP7
Sequence: MTKSELIENLVSLNPALQVKSVEDGVKEILEQIMLFLERGERVEVRGFGSFSLHYRQPRVGRNPKTGESVKLDAKYVPHFKAGKDLKERVDLV
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PPME1_EMENI
Sequence: MSDLQKSFAKSKLAKLPPEPPPIPESVADEDDDSGSSTETVTPSPVKQLFARPGGTRGFFDQELYLQRRVNDLDIVHHVYLTSPTNSGPLFVMHHGAGSSGLSFANCAAEIRKILPNAGILSADARDHGSTSVKRASEDGEADPETARLDLSLDTLNQDLLFVIRETQAKMGWETLPDIVLVGHSLGGAVITDVAKKGELGGKLLAYAVLDVVEGSAMDALQSMETYLSTRPSRFPSLPSGIEWHTRSRTIRNRTSARVSVPSLLYHEDVPKDPSKPWVWRTNLAETKPFWEGWFVGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPDAGHFIQEDQPARTAQILVDFYKRNDRSALVLPPKVADMQASAAMKKGAGAGVPLGKAEGGTTGSFKRS
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates the phosphatase PP2A catalytic subunit (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: BARF1_EBVG
Sequence: MARFIAQLLLLASCVAAGQAVTAFLGERVTLTSYWRRVSLGPEIEVSWFKLGPGEEQVLIGRMHHDVIFIEWPFRGFFDIHRSANTFFLVVTAANISHDGNYLCRMKLGETEVTKQEHLSVVKPLTLSVHSERSQFPDFSVLTVTCTVNAFPHPHVQWLMPEGVEPAPTAANGGVMKEKDGSLSVAVDLSLPKPWHLPVTCVGKNDKEEAHGVYVSGYLSQ
What is the function of this protein?
Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1.  May inhibit interferon secretion from mononuclear cells.  Exhibits oncogenic activity in vitro (By similarity).
What are the official names of this protein?
Secreted protein BARF1, 33 kDa early protein, p33.
What are the subcellular locations of this protein?
Secreted. Note=Massively secreted in the serum of EBV-induced nasophyryngeal carcinoma patients.
Protein: CYSG1_YERP3
Sequence: MDYLPLFADLKQRPVLIVGGGEVAARKIELLHRAGAQVWVVAQTLSSELEQQYQDGRIHWLAQDFLPEQLDNVFLVIAATNDTVLNAAVFAAADQRCILANVVDDQPLCSFIFPSIVDRSPLVVAISSSGQAPVLARILREKLEALLPTRLSDMAAIAGRWRGRVKQHMASMGERRRFWEHAFSGRFASLISRGQLTEAENELQLSLEGQHRALGEVALVGAGPGDAGLLTLRGLQVMQQADVVLYDHLVSPEVLDLVRRDAERICVGKRAGAHSVTQEATNQLLVTLAQQGKRVVRLKGGDPFIFGRGGEELQVVAQAGIPFQVVPGVTAAAGATAYAGIPLTHRDHAQSVTFITGHCRPDGDDLDWQALARGRQTLAIYMGTVKAAAISQQLIAHGRSSTTPVAVIGRGTRVDQQVLIGTLAQLESLAQQAPTPALLVIGEVVNLHHQIAWFGQQPQTESAINPSVVNLA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: DNM1L_HUMAN
Sequence: MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
What is the function of this protein?
Inhibits peroxisomal division when overexpressed.
What are the official names of this protein?
Dynamin-1-like protein, Dnm1p/Vps1p-like protein, DVLP, Dynamin family member proline-rich carboxyl-terminal domain less, Dymple, Dynamin-like protein, Dynamin-like protein 4, Dynamin-like protein IV, HdynIV, Dynamin-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Note=Mainly cytosolic. Recruited by RALA and RALBP1 to mitochondrion during mitosis (PubMed:21822277). Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Mitochondrial recruitment is inhibited by C11orf65/MFI (By similarity). Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Binds to phospholipid membranes (By similarity).
Protein: ACPS_CLOK5
Sequence: MIFGVGVDIVEIRRIKEAIEKHNTFIDRIFSKNEIEYLKNRNLRPEFVAGRFAAKEAVVKSLGSGFRGFDFKDIEIDRTASGRPTVVLKGKAKLMANKYGNYKIHLSISHGVDNAIAYAIMEVDKIEDSDCKDI
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35E1_HUMAN
Sequence: MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLATVTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARKHLLPVTTADLSSKERHRSPLEKPHNGLLFPQHGDYQYGRNNILTDHFQYSRQSYPNSYSLNRYDV
What is the function of this protein?
Putative transporter.
What are the official names of this protein?
Solute carrier family 35 member E1.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35E subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACCA_STRPB
Sequence: MTDVSRVLKEARDQGRLTTLDYANLIFDDFMELHGDRHFSDDGAIVGGLAYLAGQPVTVIGIQKGKNLQDNLARNFGQPNPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIAKNLMEMSDLKVPIIAIIIGEGGSGGALALAVADQVWMLENTMYAVLSPEGFASILWKDGSRATEAAELMKITAGELYKMGIVDRIIPEHGYFSSEIVDIIKANLIEQITSLQAKPLDQLLDERYQRFRKY
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OXR1_HUMAN
Sequence: MTKDKNSPGLKKKSQSVDINAPGFNPLAGAGKQTPQASKPPAPKTPIIEEEQNNAANTQKHPSRRSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVSPLSPTSSEAEFDKTTNPDVHPTEATPSSTFTGIRPARVVSSTSEEEEAFTEKFLKINCKYITSGKGTVSGVLLVTPNNIMFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDSKIKESLPIDIDQLSGRDFCHSKKMTGSNTEEIDSRIRDAGNDSASTAPRSTEESLSEDVFTESELSPIREELVSSDELRQDKSSGASSESVQTVNQAEVESLTVKSESTGTPGHLRSDTEHSTNEVGTLCHKTDLNNLEMAIKEDQIADNFQGISGPKEDSTSIKGNSDQDSFLHENSLHQEESQKENMPCGETAEFKQKQSVNKGKQGKEQNQDSQTEAEELRKLWKTHTMQQTKQQRENIQQVSQKEAKHKITSADGHIESSALLKEKQRHRLHKFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTREPGFIVVKKIEESETIEDSSNQAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSKQVATVKADLESESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPLKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAFE
What is the function of this protein?
May be involved in protection from oxidative damage.
What are the official names of this protein?
Oxidation resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
Protein: EKI1_YEAST
Sequence: MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF
What is the function of this protein?
Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine branch of the Kennedy pathway.  Also exhibits choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway, but its preferred substrate is ethanolamine.
What are the official names of this protein?
Ethanolamine kinase, EK.
What is the protein family that this protein belongs to?
Belongs to the choline/ethanolamine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAS1_MALDO
Sequence: MAALRSFLKKRSSVLCNGAMRRKLFSTEVSQPLTDSPSFAQRIRNLPKDLPGTQIKTQVSQLIGRTPIVYLNKVTEGCGAYIAVKQEMFQPTASIKDRPALSMINDAEEKGLITPGETILIEPTSGNMGISMAFMAAMRGYKMVLTMPSYTSLERRVCMRCFGADLILTDPTKGMGGTVKKAYDLLESTPNAYMLQQFSNPANTKVHFETTGPEIWEDTNGQVDIFVMGIGSGGTVSGVGQYLKSKNPNVQIYGVEPAESNVLNGGKPGPHSIMGNGVGFKPDILDLDMLERVIEVTSEDAVNMARQLALKEGLMVGISSGANTVAAMELAKKPENKGKLIVTVHPSFGERYLSSVLFQELRQEAENMQPVAVDYP
What is the function of this protein?
Probably involved in the detoxification of cyanide that arises from ethylen biosynthesis in ripening fruits.  Has only background level of in vitro cysteine synthase activity.
What are the official names of this protein?
L-3-cyanoalanine synthase 1, mitochondrial, MdCAS1.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LPXK_ACTP7
Sequence: MNIWQSTSIITWLLAPFSLLFWLVSQIRLFLFRKKILKSYRSPVPVLVVGNISVGGNGKTPVVVWLVEQLQQRGVKVGVISRGYGGKSKDFPQLVTNQSSAEMVGDEPVLIVQRTGVPLAISANRQQSIELLLNQFKLDLIVTDDGLQHYALQRDIEWVVVDGIRRFGNGFVLPAGGLRELPSRLQTVQAIICNGGIAHQNEHLMTLEPEFAVNLRTGEQKPITDFIGQECVAIAGIGHPPRFFNMLENLGVKLLKTQGFADHQAFEPAQLKALAAEQIPLLMTEKDAVKCRTFAQQNWWYVPVSAKFSPESTACLLEPILKRLGK
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: SECB_BURO1
Sequence: MSDVENQPFFNIQRVYLKDMSLEQPNSPAIFLEQDMPSVEVEVDVKADRLAESVFEVVVSGTVTAKVKDKVAFLIEAKQAGIFDIRNIPDEQLDPLVGIACPTILFPYLRSNIADAITRAGFPPIHLAEINFQALYEQRLAQLQQQAGAAAGAPNGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
Protein: END4_YEREN
Sequence: IMRDPRFDNIPLILETVNPDIWAEEIAWLKSQAEI
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: SPRTL_STRT1
Sequence: MNLTDYVKTVSIEDFGWKFKHQALWNKRLRTTGGRFFPKDGHLDFNPKLYEEHGLETFRKIVRHELCHYHLYFQGKGCKHGDRDFKDLLARVDGLRYAPKMRNQAENYFLYQCQSCGHTYRRKRRVNTQKFGCGLCQGKLIFLNQS
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_BIFAA
Sequence: MIILGVDPGLTRCGVGVIEAGAYRRLSFIHVDVVRSDPKTSQDLRLLAIYNGLVEKIERFAPDAVSIERVFAQENRNTVLGTAQAAGLAMLAAAQRGIPVALHTPTESKLAITGNGKAEKIQMERMVARILGLNTLPKPADAADALAIAICHALRPAGALQGGEREQHLTAAQRQWAQASQKAARRQGVRRGM
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: 4HPE2_AGRRK
Sequence: MRRSFFCIDSHTCGNPVRVVAGGGPLLPHVSMAERREIFVRDHDWVRKALMFEPRGHDIMSGAIIYPSVREDCDFAALFIEVSGCLPMCGAGTIGLATVAIEEGLITPRVPGRLSIETPAGKVDVDYQLKDGFVEAVRLFNVASYLHSRDVVVDVSGLGSLSVDIAYGGNFYAVIEPQENWSGLDGMSASDIVTLSQRLRDALSVVCDPVHPDDERIRGVHHAIWCDAAGSENADGRGAVFYGDKAIDRSPGGTGTSARMAQLYGRGRLGIGDSFRNESLIGTVFEGRIEGAALVGGIPGILPSIGGWARVIGHNTIFVDERDPLAHGFQIR
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate.  Displays no proline racemase activity.
What are the official names of this protein?
4-hydroxyproline 2-epimerase 2, 4Hyp 2-epimerase 2, 4HypE 2.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: DDL_CAUSK
Sequence: MTPANPKPLANHHIAVLLGGPSAEREVSLVTGAAYAAALERLGARVSRVDPGKDVAQVLTALAPDLVFNGLHGRWGEDGCVQGVLETLGLAYTHSGVLASALAMDKAKSKAVLAAAGIPVPGGGLFDRHDVAQGHVMPPPYVVKPNAEGSSVGVSLVFEGANGPPRQLAAPDWAFGEQVMVEPYIPGLELAVAVVGESNGPRALAVTEIRSSTGFYDYDAKYSQGGSIHVLPAPIPDAVRDRALHLAKLGHTALGCQGVTRSDFRYDDINDLLVLLEVNTQPGMTPTSLVPEQADHAGVSFDRLVFWIVEDAYARRFAGGIA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.