PharMolix/UniProtQA huggingface dataset:
Protein: MURG_BRUA2
Sequence: MDNLANQGVIVLAAGGTGGHLFPAEALAHELRARGWDVHLATDARAQRFVGAFAQDHVHVIRSATIAGRNPVALLKTFWSLWQGNLDSRKLFRRLKPKLVVGFGGYPTLPPLYAASNMGIPTLIHEQNAVMGRANKGLAGRVKAIAGGFLPENSGAYAAKTVITGNPVRSPVLVAAATPYTPAGKDDRFRLLVFGGSQGAQFFSQAIPAAVALLPEHERARLLITQQARKEDEASARQAYEKLGVPADVAPFFNDMPARMADAHFVIARSGASTVSEITVIGRPAMLVPFPHALDHDQAANAAALAAAGGAEVVRQADLSPQRLAEMLQSAMNEPERLEQQAKAAKSVGKPDAARLLADLAEAIASGKTVQEFKEGNRP
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FAM74_HUMAN
Sequence: MWRELRGCPGGDVETAQRLSQRRRGKSSEAVPEKTWRAQRMSQRRRGESSEAVPEKTWKELRNSETVPEKTWKQLRGCLQEDVQRVQRLSRRRHGESSKAVHKKMWREFRGCRYCCTWLFFFG
What are the official names of this protein?
Protein FAM74A4/A6.
What is the protein family that this protein belongs to?
Belongs to the FAM74 family.
Protein: Y697_ENTFA
Sequence: MGIPKEGEFVTIQSYKHDGHLHRTWRDTMVLKTSEYSLIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIREKGVSYYCNLASPYVLDDEALKYIDYDLDIKVFPDGEKRLLDVDEYEFHSKLMDYPEDIDFILKENVKTLVDWINNEKGPFSPEYVDIWYQRYQQLSKK
What are the official names of this protein?
UPF0374 protein EF_0697.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: CCME_VIBC1
Sequence: MNPRRKKRLGIVLAIFIGISATIGLMLYALNQNMDLFYTPTELVNGKPDGTKPEVGQRLRIGGMVVEGSVRRDPESLKVSFDLHDVGPKVTIVYEGILPDLFREGQGIVAQGVLEDATTVKAFEVLAKHDEEYMPPEIAEAMKKTHEPLQYTTEQKQGSGQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: YEJL_ECO8A
Sequence: MPQISRYSDEQVEQLLAELLNVLEKHKAPTDLSLMVLGNMVTNLINTSIAPAQRQAIANSFARALQSSINEDKAH
What are the official names of this protein?
UPF0352 protein YejL.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: ZRG8_YEAS7
Sequence: MRSFIKAHKKSTSFDESPKRHSNFSGNTNNSSQRSSDDSLDFLPSTPSQMNYDSIPPPAKHSPGFESFHRLANKTSKLFKKTSNSNLNSHLASTPTTSTNQTTSNSFVLQNPPTKNTGPPPPLPPPLFPSSSTSSFSRHDNESEYTAYKKTSPAKDFNRTTDSLPAIKGTITHSWGDSKVESHVIILNDPASPASNTSEATSSKQFKTPIIGNENLTSTTSPSNLEPAIRILNKNKGKQQENIDDAEDGSSKKEHHVYKALALAKNRNRQARIHSHDDIINLGKASQMDMSLLAAAFSGNSTTTINNDQSSNEQTDEKILDIERVTTTSTLTSSETTSPINKSPCFYSQTLSLSPKIRHGDLQSSPSKVNKNDSQNETLNKKKVRISLNRKEEEKVYSLNNNSDEYSVNEKETHKANDCNDESSENGDGDNDHDDDYDDDDDDDDDDDESEFSFEYAGINVRTSSVKYYSKPEPAANVYIDDLYEDENFDDDMNCIEDDESGNEGNEICGLSTRFEETSLKSNKVKKFNDLFNLSDDDEEEDGKDNSNNGDENESDNLYQKRLENGKETFNGNHGGHHDDASLGETVDNKEQFLINDNVKKPIQKYNDLFDLSDEDDNDDKEMSEAESYMFSDEAPSIESGPANAKSTRGIYSQSNKNIIRDGKPNYSFSLKRNNSDDETEHTSAIKASLTGTTGSTKPTVKSFSDIFNVDDSASDAESDSGTGGNNSNGLVSNDSERQVSLQSSLYETKSESHPPNHPHSQILQTPAKIVITPSVSDAQSQALAITDDDGEDDDDDTSSILRTPFQLIDSSHSQQPHYASPQYTAVLNSPPLPPPARSQSLKYHDLNCDLDSEVPRPMSNLFFIDEAEEDEYNQKSKFFDFDHYDIDEINGIPEDFNFSDSERDDLNRRTLKSPLRGGSKNREVSPFSSVSSSFRSTHSFNGKLTINQGAKELAPMKNKIELTNKTVTFFNSNNWNTYDCNSLSRKTSSQMRDSKYQNHNVGQNVEPSSVRSPQHQISNGLDGKCNDNYVISPNLPTTITPTNSFTKPTPEFSNDYSLSPIQETPSSVQSSPKRA
What is the function of this protein?
Involved in the integrity functions of RAM, a conserved signaling network that regulates maintenance of polarized growth and daughter-cell-specific transcription.
What are the official names of this protein?
Zinc-regulated protein 8.
What is the protein family that this protein belongs to?
Belongs to the ZRG8 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud. Bud neck. Bud tip. Note=Localized to the cortex of small and large buds during bud growth, to the bud neck during mitotic exit and to the tips of mating projections in pheromone-treated cells.
Protein: RL2_SALAR
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLVEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PFD4_CAEEL
Sequence: MPEHTKVSAEDQALLNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEDSASIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKVLSEKTSELDAISADMEQIKKVLYAKFGDQINLDAEE
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
What are the official names of this protein?
Probable prefoldin subunit 4.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
Protein: HMAS_AMYOR
Sequence: MQNFEIDYVEMYVENLEVAAFSWVDKYAFAVAGTSRSADHRSIALRQGQVTLVLTEPTSDRHPAAAYLQTHGDGVADIAMATSDVAAAYEAAVRAGAEAVRAPGQHSEAAVTTATIGGFGDVVHTLIQRDGTSAELPPGFTGSMDVTNHGKGDVDLLGIDHFAICLNAGDLGPTVEYYERALGFRQIFDEHIVVGAQAMNSTVVQSASGAVTLTLIEPDRNADPGQIDEFLKDHQGAGVQHIAFNSNDAVRAVKALSERGVEFLKTPGAYYDLLGERITLQTHSLDDLRATNVLADEDHGGQLFQIFTASTHPRHTIFFEVIERQGAGTFGSSNIKALYEAVELERTGQSEFGAARR
What is the function of this protein?
Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin.  Catalyzes the conversion of p-hydroxyphenylpyruvate to p-hydroxymandelate.  The decarboxylation and hydroxylation activities of HmaS show novel and distinct regioselectivity, compared to all other known p-hydroxyphenylpyruvate dioxygenases, by hydroxylating the benzylic position of the substrate instead of the phenyl ring.
What are the official names of this protein?
4-hydroxymandelate synthase, HMS, HmaS, 4-hydroxyphenylpyruvate dioxygenase II.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: CARA_LISMF
Sequence: MTKRILMLEDGNYFIGDAIGSEKETIGEVVFNTGMTGYQETITDPSYYGQIITFTYPLVGNYGVNRDDFESINPAVKGVVVREAAEFPSNWRNQITLDEFLKEKGIPGIAGIDTRKLTKLIRKEGTLKGILAAETANKEELLHHLRSVRLPVDQVHEVSSAKAFASPGDGKRVVLVDYGVKSSILRELNKRNCYVTVVPYNTTAEEILAMHPDGVMLSNGPGDPKDVPEALEMIRGIQGKLPLFGICLGHQLFALANGADTFKLKFGHRGANHPVKELATGRVDFTAQNHGYAVEKDSLIGTDLKVTHIELNDETVEGLAHKEYPAYTVQYHPEANPGPSDVNYLFDEFMEMMNGKEEGELHA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: YIDD_CLOK5
Sequence: MKKFLIFLIKVYRKYISPLKVPCCRFYPTCSQYVLEALQKHGIIKGGFMSIKRILRCNPFCKGGYDPVK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NCPR_PIG
Sequence: MGDSNVDTGTTTSEMVAEEVSLFSATDMVLFSLIVGLLTYWFIFRKKKDEVPEFSKIETTTSSVKDSSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMAADPEEYDLSDLSSLPEIENALAVFCMATYGEGDPTDNAQDFYDWLQEADVDLTGVKYAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFDLGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDMDTAVVYTGEMGRLKSYENQKPPFDAKNPFLAVVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGEILGTDLDIVMSLNNLDEESNKRHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEQLRKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCERLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKSGRVNKGVATSWLRAKEPAGENGRRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLQEQGKEVGETLLYYGCRRSDEDYLYREELAQFHAKGALTRLSVAFSREQPQKVYVQHLLKRDKEHLWKLIHDGGAHIYICGDARNMARDVQNTFCDIVAEQGPMEHAQAVDYVKKLMTKGRYSLDVWS
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.
What are the official names of this protein?
NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: RR15_AMBTC
Sequence: MVINSFISSISKEEKKGSVEFQVFCFTDKIRKLTSHLELHKKDFLSQRGMRKILGKRQRMLAYLSNKNKVRYKKLIGQLNIREPKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SHE9_DEBHA
Sequence: MNVSTYNIRPIYRSHRLIRSRSCFCILNPLAVRFYSSKNFSSSNNPIANSNEKSSHHDEKLREIIETTNFGSELRKKKEMHDKKLHEQKAYEKYEKEAEGKETPQEKGQEEDSVSNSDKSTPEEEVKANDGSIIASEISEDIQREIGNLPSQKETRRYQLSKKLEEYLDSLQDTIFTATRALNDVTGYSSIEQLKKSINDLEVQLKNEKDNVKKCKDLYSQAILRRSLSQREINELLTRKHNWSPDDLERFTTLYRNDHVNEQEESNTHNALNDAESKVDAIQLKLTQSILTRYHEEQIWSDKIRRASTWGTWILMGINLFLFILATFLVEPWKRKRLVGSFEDKVKQAIFEMSEVQEGKWDQMILQQKESAAQQSVSTLKSWWFNSDDDSEPNKSSVYPMILTPVDNSWQGLKTTIRSHYNALRSSTISTLQFEKYEFAWFATTITILGCALGSILTVYFK
What is the function of this protein?
Required for the maintenance of the structure of the mitochondrial inner membrane.  Involved in mitochondrial morphology.  Causes growth arrest when highly overexpressed (By similarity).
What are the official names of this protein?
Sensitive to high expression protein 9 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SHE9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COMEC_BACSU
Sequence: MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRHAFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETPDKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHIHWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVEDEVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLTGAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAVSFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFYTFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAPVLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQGDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDALILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRGDVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFPNIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIRVLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN
What is the function of this protein?
The comE operon is required for the binding and uptake of transforming DNA.  ComEC is required for internalization but is dispensable for DNA binding.
What are the official names of this protein?
ComE operon protein 3.
What is the protein family that this protein belongs to?
To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TAM_RHOPB
Sequence: MADWDAEQYLKFEDERTRPARDLLAQIPLDDPRRVADIGCGPGNSTELLVRRWPQARVTGVDTSADMLRQARERLPGHNFIEANIAHWAPPVGTDVVFANAVFQWVPNHLKHMQRLVGALEPGGVLAVQMPDNLDEPSHIMMREVAFQEPWRHQLAEAAQLRDNLPKPGAYYDALRPLCSRLEIWHTVYNHVLDDAMAIVEWVKGTGLRPFIDPLELPERKAYLAAYTARIAAAYPPQADGKVLLRFPRLFVVAIK
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALQ_STRPN
Sequence: MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYAKIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEWPDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPIYVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYKWWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEELGELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTGTHDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDLLELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK
What are the official names of this protein?
4-alpha-glucanotransferase, Amylomaltase, Disproportionating enzyme, D-enzyme.
What is the protein family that this protein belongs to?
Belongs to the disproportionating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUGE_BACSU
Sequence: MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDPDLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP
What are the official names of this protein?
Uncharacterized protein YugE.
Protein: MTP8_ORYSJ
Sequence: MGPVRHILNERKSRKIAAFLLINTAYMFVEFTSGFMSDSLGLISDACHMLFDCAALAIGLYASYIARLPANGLYNYGRGRFEVLSGYVNAVFLVLVGALIVLESFERILEPREISTSSLLTVSIGGLVVNVIGLVFFHEEHHHAHGEAHSCNGGLQSSENHNKSRNRHHIDHNMEGIFLHVLADTMGSVGVVISTLLIKYKGWLIADPICSVFISIMIVSSVLPLLRNSAEILLQRVPRSLEKDIKEALDDVMKIKGVIGVHNFHVWNLTNTDIVGTFHLHITTEADKSSIREKASDIFHEAGIQDLTIQIECVKR
What is the function of this protein?
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
What are the official names of this protein?
Metal tolerance protein 8, OsMTP8.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: RL18_ACIC1
Sequence: MPQLLSRRVGRGSTRTAARMRRHFRVRKKISGTPERPRLVVHRSARHVFVQIVDDTRGHTLASASSFEPEMRSFAGDKTAKARRVGQLIAERAKAAGITTVVFDRAGYRYHGRVAAIADGAREGGLVL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TMCAL_STRTD
Sequence: MTVTGIIAEFNPFHNGHKYLLDHAEGIKIVAMSGNFVQRGEPAIVDKWIRAQMALENGADLVVELPFFTAVQSADYFASGAVDVLSRLGIDSLTFGTEEVLDYQTIADVYSEKSEEMEAFVESLPSDLSYPQKTQKMWEKFAGVDFTGNTPNHILGLAYAKACAGKGITLNPIQRQGAGYHSLDKEVSFASATSLRLHKEDSDFVDKFMPNSKLFQTSPQVSWDNYFQLLVYQILTNPDLTSVFQVNEEIASRLKAAVREISSVEELVDKVATKRYTKARVRRILTYILVGAVDNSLPKSIHVLGFSQKGQFHLKSVKKSVDIVARIGRKPWDMLTQQADNVYQLGNPELCEQNFGRVPIRVK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LATS1_MOUSE
Sequence: MKRGEKPEGYRQMRPKTFPASNYPGSSRQMLQEIRESLRNLSKPSDASKAEHNLNKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETSSSRSPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISKMSYQDPRREQMSAAAARPINATMKPGNVQHSINRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGIAAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPSSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQSDFIVHQNVPTGSVTRQPPPPYPLTPANGQSPSALQTGASAAPPSFANGNVPQSMMVPNRNSHNMELYNINVPGLQTAWPQSSSAPAQSSPSGGHEIPTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWMPQPVQTVQPTPFSEGTASSVPVIPPVAEAPSYQGPPPPYPKHLLHQNPSVPPYESVSKPCKDEQPSLPKEDDSEKSADSGDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNNRDLVYV
What is the function of this protein?
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:21145499).  Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint.  Negatively regulates G2/M transition by down-regulating CDK1 kinase activity.  Involved in the control of p53 expression.  Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1.  May also play a role in endocrine function.  Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.
What are the official names of this protein?
Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Protein: FOLD_METC4
Sequence: MIAQVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARSTGILSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDVDGFHPVNAGLLATGQPGLVPCTPLGCLRLVQSVAAELVGQNVVVVGRSTIVGRPAAQVFLNADCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSGYRLVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTVACAEALAIRAPEVMSPDNRLHFDHADV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ATG1_MAGO7
Sequence: MADRSARRARPGDDSVGQFVIGAEIGKGSFAQVYMGKHKVSGAAVAIKSVELARLNKKLKENLYGEINILKTLRHPHIVALHDCVESATHINLMMEYCELGDLSLFIKKREKLSTNPATHDMARKYPNVPNSGLNEVVIRHFLKQLSSALKFLRESNLVHRDVKPQNLLLLPSPEFREVNKLARPILTASQDSLVPVAGLASLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDAKADLWSVGTVLFEMIVGRPPFRASNHVELLRKIEAAEDVIKFPRETTISSEMKGLTRALLKRNPVERISFENFFAHPVIISSIPGLVEDDIPKPEASEQRSSSKDTRAASKSDDPIASPRKYSFRRHPTDNDQIRDQFRRVEPPSSAAESAPSRQTSAFSGIAAEARKQAAAEASARTGQSSRNEPGDNLVPRRPQAQPSTSAPSKPGLYEERRRGISNASLNRSNRESSSPTSAALANDSARAPPQQTSRRVQAEEREKAAQDVAFERDYVVVEKKHVEVNAFADEMAANPRLGGQGTPLSPKSGQIVRRATQQGNPTSTTGAIPAAPSRTMQIAQGTQRHYHERGTSLSASPGSTASFITKAIQDASLRLLGIKYPAGLTKGASPPELYNPYPAYPTPSPPVGLISSGKQSTPVDEDARVAQLIEEHATRSDVVYGFAEVKYKQLVPLAPSAEHGLGGTTLEDMPTGEEDVLTVEAIVSLSEEALVLYVKALTLLAKSMDIASLWWARKNRGDQANNALSSTRDSVNTQTLSLRINSAVQWVRSRFNEVLEKAEVVRLRLMDAQKRLPDDHPSHPSNHPQGSESVNGASAEGVFLTVGVTAEKLMYDRALEMSRTAAINEITNEDLAGCEISYVTAIRMLEAVLDNDEDAPKRRLSANMDDSGGDGEDGHAEINADDQQAVQKMIHMIRSRLTSVRSKVRMISNASKAQQQSQPQSLIRRRSGDVTPRSVPSYSS
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity).  Autophagy is essential to fungal development, production of appressorium turgor, and pathogenicity in rice blast disease (PubMed:17416896).
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: OXDA_FUSVN
Sequence: MSNTIVVVGAGVIGLTSALLLSKNKGNKITVVAKHMPGDYDVEYASPFAGANHSPMATEESSEWERRTWYEFKRLVEEVPEAGVHFQKSRIQRRNVDTEKAQRSGFPDALFSKEPWFKNMFEDFREQHPSEVIPGYDSGCEFTSVCINTAIYLPWLLGQCIKNGVIVKRAILNDISEAKKLSHAGKTPNIIVNATGLGSYKLGGVEDKTMAPARGQIVVVRNESSPMLLTSGVEDGGADVMYLMQRAAGGGTILGGTYDVGNWESQPDPNIANRIMQRIVEVRPEIANGKGVKGLSVIRHAVGMRPWRKDGVRIEEEKLDDETWIVHNYGHSGWGYQGSYGCAENVVQLVDKVGKAAKSKL
What is the function of this protein?
This enzyme can effectively convert cephalosporin C into 7-beta-(5-carboxy-5-oxopentanamido)-cephalosporinic acid.
What are the official names of this protein?
D-amino-acid oxidase, DAAO, DAMOX, DAO.
What is the protein family that this protein belongs to?
Belongs to the DAMOX/DASOX family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: M1250_ARATH
Sequence: MGYGVCHFYLLFIINGAPQGLVTPSRGLRQGDPLSPYLFILCTEVLSGLCRRAQEQGRLPGIRVSNNSPRINHLLFADDTSSARWIPLAAQIWPIFFLSMRLFQGNPVNHPMSNLYFLGSLP
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg01250, ORF102.
What are the subcellular locations of this protein?
Mitochondrion.