PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_RICBR
Sequence: MSVVNFYGQLSNTQQFDQIRINIASPEQVRSWSFGEVIKPETINYRTFKPEKDGLFCARIFGPVKDYECLCGKYKRMKNRGITCEKCGVEVTVSRVRRERMGHIELAAPVAHIWFLKSLPSRISTLLDMTMRDIEKILYFENYVVVDPGLSILQKGELLTEEELQKAKDKYGEDAFTASIGAEVVQQMLKELDFPTLKQELYEELQNTTSEVKKKKLVKRLKLVEDFLESENKPEWMIMNVLPVMPPELRPLVMLDGGRFATSDLNELYRRVINRNNRLKKLIESKAPDIIVRNEKRMLQEAVDALFDNGRRGRAAKNANKRPFKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSKLELYGIATTIKAAKRMVEAEKPEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCAAFNADFDGDQMAVHIPLSIEAQLEARVFMMSTNNILSPANGRPIIVPDKDIVLGLYYLTLAFDHEVGEGMMFSDLTEMEHALYNKFITIHTKIKYRRNQLNAEGKIVPVIVDTTYGRLMVGELLPSNPNIEYKFINKPLTKKDISLVIDLVYRHCGQKATVIFADQLMKLGFKYACSSGISFGMDDMVVPKSKIVHIDETQLEIKEFEQQYSNGLITYGEKYNKVIDAWSRCTDRVANDMMKEIAKPPVSDDSNQQKINSIYMMAISGARGSFQQIKQLGGMRGLMTKSNGQIIPTPIIANFKEGLTVFECFNSANGMRKGQIDTALKTASSGYLTRKLVDVAQDCIITEKDCNTDKGIEVKSIIEGGEVIVPLAEMILGRTAAINIYHPVTNDLILTKGELINESKLEQIESAGLDRIMIKSVLTCESSTGICAICYGRDLATGSLVSEGEAIGVIAAQSIGEPGTQLTMRTFHIGGAATKGAEVSSVEASYDAKVKILSRNVVINSEERKIVMSRNCELLLLDNNGNEKAHSKIPYGARLLVDEGDMVTKTQKLAEWDPYTIPIITEKSGKVLFKDMVEGISVRDVTDEATGIPSKVIIESKQYSRGAELRPRIQLLDAKGEIIMLSNGLEARYYLPVGAVLSVEDGVQISVGDIIARIPKESTTTKDITGGLPRVAELFEARRPKDHAVIAEIDGRVEFGKDYKSKRRIIIHPVDGSMGLEYMVPKGKHVVVNEGDFVKKGDLLIDGNPVLQDILKVMGVELLASYIVKEVQAVYRLQGVKIDDKHIEVIIRQMLQKVEITDSGGTTLLVGEKIDRREFDEINEKAIKNGLRPADAQLILQGITKSSLQTRSFISAASFQETTRVLTEAAIAGKVDKLRGLKENVIVGRLVPAGTGFLYGQNA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: TYPH_BURO0
Sequence: MFLPQEFIRRKRDGQPLDRDGMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALGLGGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARLAPADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILTDMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKLQQALDSGAAAERFARMVVALGGPADLLDAPARHLARAAVIVPVPAPASGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIESGEPLGFVHARDEAAAAHAADAIRRGYVLGDTGEAPPTLYRQIG
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: FEX1_CANAL
Sequence: MVAPLVSESQSSSIEETDEQQQQYQQLARRRTIQSDLVDIEAESISSALPEGFNYEKKTTATRFLDKTQKYYPVILNIVHGAIWGVLVRKGLMSLTTYSGSFLSGVIWANFAACVVMGLAIDGEVFWIRLLEEKDYPNKGAIPVYTGLTTGFCGTVSSFSSVILEAFNKAADTDIGVRHHYPNGAYGIMQFLAVILAQFGLSIMGFHMGKQFSAVVDNYLPLVTKRIYKVLELTSMILGVVLVVITCILIGVKKQGSWRSWTFSMLFAPFGALLRYYLSKFLNNKVSNFPLGTFTANFLGTLLLAVFTLLARGKLPGGKGHIVTNTIALHVLEGLDDGFCGGLTTVSTFVVELFGLKTLFSYRYGTISILVCFAGVVLILGSYNWSVGLD
What is the function of this protein?
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
What are the official names of this protein?
Fluoride export protein 1.
What is the protein family that this protein belongs to?
Belongs to the fluoride exporter Fluc/FEX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIGA2_VIBCH
Sequence: MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVPNGQAVTLLKLVQRHPETLSHIAEL
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB-2 toxin.  Binds to its own promoter and regulates transcription of the higB-2/higA-2 operon.
What are the official names of this protein?
Antitoxin HigA-2.
Protein: TPS1_MELLP
Sequence: MSIYDDILKQFPTIDEWSDSDQKIMLEPYTYLGINTAKELPSMVTKALNHWYQVPQPALDIVLQIVGPIHAACLLIDDIQDDSDLRGGNPVAHKVYGVAQTINTATYVCFDAYHKISELRPFLKSPETIDLWSIINDEIAALHRGQWIDLYWRDSLICPTEEEYLRMIHNKTGAIFRLPMRLLQALSPVDSVPDCFPLVNIVGILVQIRNDLLSLSADFTKDKGFCEDFSEGKFSFPIIHSVKADSSNSLLMDILRLRPKDEATKMKALRYMKDQTKSLDHTFDVLCKLEKTAKQELEKLGGNSELSSIFERIHLSPTPEIEDH
What is the function of this protein?
Terpene synthase that shows monoterpene synthase activity and produces (E)-beta-ocimene as a major product and linalool as a minor product, using geranyl diphosphate (GPP) as substrate (PubMed:32913319).  Shows also sesquiterpene synthase activity as it is able to convert farnesyl diphosphate (FPP) into (E,E)-alpha-farnesene (PubMed:32913319).  Finally, TPS1 can convert geranylgeranyl diphosphate into (E,E,E)-alpha-springene (PubMed:32913319).
What are the official names of this protein?
IDS-like terpene synthase 1, ILTPS1.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: LCL2_TALSN
Sequence: MLAKPLTAIWTLFLLISTAQAQFQFFEQMFGGGGAQQGHPHEQEASSDSAWYQRTWEGAHCTRYLCPGTLSCVHFPHHCPCPHPNVEDKVELGEGSAVCVSRGGFAPGEAARKIELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: ATG29_ASHGO
Sequence: MNSKNTIVYVKVPGRQREGFVDPPPFEWNQHQDRKLWAHISTIEDKDDIDWQLLSNQTNAPEFFIRKRVYQLFRVHLKSIEQEIYSHTSADRAPNRSSQAGDEPAASVGVLNGYGQNINDIHDLSSLQTPPTCRGKANKDEDGGNSSGISELSSLSVSKSALEEALMDRLQL
What is the function of this protein?
Plays a role in autophagy.  Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions.  Also plays a role in mitophagy and regulation of filamentous growth (By similarity).
What are the official names of this protein?
Autophagy-related protein 29.
What is the protein family that this protein belongs to?
Belongs to the ATG29 family.
What are the subcellular locations of this protein?
Preautophagosomal structure. Note=Localizes also to other perivacuolar punctate structures.
Protein: PER59_ARATH
Sequence: MKTQTKVMGGHVLLTVFTLCMLCSGVRAQLSPDIYAKSCPNLVQIVRKQVAIALKAEIRMAASLIRLHFHDCFVNGCDASLLLDGADSEKLAIPNINSARGFEVIDTIKAAVENACPGVVSCADILTLAARDSVVLSGGPGWRVALGRKDGLVANQNSANNLPSPFEPLDAIIAKFVAVNLNITDVVALSGAHTFGQAKCAVFSNRLFNFTGLGNPDATLETSLLSNLQTVCPLGGNSNITAPLDRSTTDTFDNNYFKNLLEGKGLLSSDQILFSSDLAVNTTKKLVEAYSRSQSLFFRDFTCAMIRMGNISNGASGEVRTNCRVINN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 59, Atperox P59, ATPN, Peroxidase N.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL15_LACLA
Sequence: MELHSLKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKSRSGGGVRPGFEGGQTELFRRMPKRGFLNVNRKEYAIVNLETLNRLEDGATVSAETLVAAKIIKDVKSGVKVLANGELTAKKLTVKVAKVSAAAKAAIEAAGGSVEEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: YE027_HUMAN
Sequence: MPSSVPKTSIESLGSPSSLSSSQASEPLCPLKHPSHRPPASTLSPNLTSSTESLGYLSSLSSSQPPEPLRPLECPSHKPCGRSLPRRRNPGWVSWSDSMQADSETDAIICPMCKAPERSCPHTWWVPSSPRVIRGVGRCSDPNLGLSWRQEAARAWCHCTSSQYPFKHPNLPTHLPKASF
What are the official names of this protein?
Putative uncharacterized protein FLJ35723.
Protein: CDGT_KLEOX
Sequence: MKRNRFFNTSAAIAISIALNTFFCSMQTIAAEPEETYLDFRKETIYFLFLDRFSDGDPSNNAGFNSATYDPNNLKKYTGGDLRGLINKLPYLKSLGVTSIWITPPIDNVNNTDAAGNTGYHGYWGRDYFRIDEHFGNLDDFKELTSLMHSPDYNMKLVLDYAPNHSNANDENEFGALYRDGVFITDYPTNVAANTGWYHHNGGVTNWNDFFQVKNHNLFNLSDLNQSNTDVYQYLLDGSKFWIDAGVDAIRIDAIKHMDKSFIQKWTSDIYDYSKSIGREGFFFFGEWFGASANTTTGVDGNAIDYANTSGSALLDFGFRDTLERVLVGRSGNTMKTLNSYLIKRQTVFTSDDWQVVFMDNHDMARIGTALRSNATTFGPGNNETGGSQSEAFAQKRIDLGLVATMTVRGIPAIYYGTEHYAANFTSNSFGQVGSDPYNREKMPGFDTESEAFSIIKTLGDLRKSSPAIQNGTYTELWVNDDILVFERRSGNDIVIVALNRGEANTINVKNIAVPNGVYPSLIGNNSVSVANKRTTLTLMQNEAVVIRSQSDDAENPTVQSINFTCNNGYTISGQSVYIIGNIPQLGGWDLTKAVKISPTQYPQWSASLELPSDLNVEWKCVKRNETNPTANVEWQSGANNQFNSNDTQTTNGSF
What are the official names of this protein?
Cyclomaltodextrin glucanotransferase, Cyclodextrin-glycosyltransferase, CGTase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: SPED_DESHD
Sequence: MEVKPLKKLRLYGFNNLTKTLSFNMYDICYAKTPEHRDAYIQYIDEEYNAQRLTSIVTEVARIVGANILNIAKQDYDPQGASVTMLIAEEHLGPENPDNDPFSPVYTDKEGPLPDAVVAHLDKSHITVHTYPESHPHGGISTFRADIDVSTCGQISPLKALNFLIESFAPDIIVADYRVRGFTRDVDGKKVFIDHKINSIQNYVDRKYRDLYQMIDVTVFQEYIFHTKMILKDFDLDNYLFGTAKKELSINDKRKIKQRLKKEMAEIFYGKNMPRI
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: HUTU_PSE14
Sequence: MTENNQDLKQNWTRHREGVVQAACGTQLTAKSWLTEAPLRMLMNNLDPEVAENPNELVVYGGIGRAARNWECYDKIVESLTQLNDDETLLVQSGKPVGVFKTHSNAPRVLIANSNLVPHWASWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRIKTRYVDEQAADLDDALARIAKYTAEGKAISIALCGNAAEILPEMVRRGVRPDMVTDQTSAHDPLNGYLPKGWTWDEYRVRSVSEPANVVKAAKQSMAEHVEAMLAFQQAGIPTFDYGNNIRQMAKEVGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDDHLHNWLDMARERISFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETESMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAERIARVLHNDPATGVMRHADAGYDIAIDCAREQGLNLPMIGR
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_SHEB9
Sequence: MSNIPTELKYASSHEWIRKEEDGSYTVGITEHAQELLGDMVFVELPEVGDTVTAGEDCAVAESVKAASDIYAPISGEVIAVNEALEDSPELVNSSAYGEGWFFRVMPSDESEVDALLDAEGYQAVIDED
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: MCP25_MAGSA
Sequence: MEGPYQRLPWGIWRMSISNWRFRAKIFLIVVLSLLGMGAIVAVNLANLHNELMAARKIKTQHVVETAHSLIGHYVKLSQSGQMSTDAAQAAAIEAIKTMRYAGTEYFWINSLAGKMVVHPIRPDMLGKDLMGLKDPAGKLFFEAMIDVVKKDKAGFVDYLWPKPGLDQPVPKVSYVKGIEEWGWLVGSGIYVDDVDSAFRAEVMNLGGIVTGVVLLVLLVSWWIGKNVVDGMRNATGGIRKLAEGDTSVEIKGHERGDEIGELVQAAEIFREHSLTMKRMSEERAEQRRQAEAERRSTLAGLATELERGVKSTVVTVSESAGRMRSTATGMAGAIDNASQESQAVAAAAQQTSSNVEAVAAAAEELSSSIRGIGSQVAESTQIAKEAVDAANRTDGVVRGLSEAADRIGEVVRLINDIAGQTNLLALNATIEAARAGEAGKGFAVVANEVKHLASQTAKATEEIGQQIASIQSTTADAVGAIESIGKTIGRMDEIANAIAEAVEQQGAATQEIARNVHEAADGAQEVSHHISSISRTASEAGVAARELLGAAAELAGESETLRNGVDRFLGEVRAM
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through variation of methylation levels.  Attractants increase the level of methylation while repellents decrease the level of methylation.
What are the official names of this protein?
Methyl-accepting chemotaxis protein Amb2333.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Found predominantly at cell poles.
Protein: ILVC_MYCAV
Sequence: MFYDDDADLTIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSRAKVSEQGLDVDTPAAVAKWADVIMLLAPDTAQADIFKNDIEPNLSDGDALFFGHGLNIHFGLIKPPAEVTVAMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGKGEALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVESGYPPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKDRMREILRDIQNGDFVKKLVANVEGGNKQLEQLRKENVEHPIEVVGKRLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: DNAA_NITMU
Sequence: MLAPDTFWLACLEYFENELSAQQFNTWIKPLRLQLSDDSPEPALRLIAPNRFVLQWVKDNFLSDITQMAENHFARPVQLQLELAGQIPASASPSTGRNNGTASHSITAVFDAPTESAQKAPKDTKDTKDAKEKQEKNPTRLNPSFTFNTFVTGKANQLARAGAIQVAERPGVAYNPFFIYGGVGLGKTHLIQAIGNFVVEQNPAAKVRYIHSEQYVSDVVRAYQHKAFDEFKRYYHSLDLLLIDDIQFFGGKNRTQEEFFYAFNALIEAHKQVIITCDSYPKEIAGMEERLISRFGWGLTVAVEPPELEMRVAILLKKALMEDIILDESVAFFIAKHIRSNVRELEGALKRVVAYSRFTGHALTLDLAREALKDLLAVQNRQISIENIQKTVADYYKIKVAEMYSKKRSRVVARPRQMAMAISKELTPLSLPDIGEAFGGRDHTTVLHGYRKIAELRASDPAVNRDFNTLLHILRG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_ALKCK
Sequence: MVPIAAIRRKLMDGSISHNELDELKKDQRKGVQELLKRYQAQQEKQQTLIQMHKQMWRYEQELKQRGYVAVCGVDEVGRGPLAGPVTACACILPDDFQLLGLTDSKKLSKAKREEYAKMISEQAVAYSIASVSAAEIDEINILQATKKAMTKAINGLSQKTDHLLLDAVRLDVPIAQTSLIKGDAKSLSIAASSVLAKVWRDRYMEELAQTYPGYGFDTHAGYGTASHLQALRTYGMTPEHRKSFRPVLEESQGLIYGT
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_BURCJ
Sequence: MRCPFCRHDDTQVVDSRVSEDGAAIRRRRRCSACDKRFTTYERVELSLPFVVKKDGSRTEFDRRKIVASMQLALRKRPVAADAIDAAVARIEYQLLATGEREVRSEKLGELVMNELRGLDTIAYVRFASVYRRFEDVSEFADVIEEFRRASPAKTPRKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HDAC2_ORYSJ
Sequence: MDPSSAGAGGNSLASASCGDAQKRRVCYFYDPEVGNYYYGQGHPMKPHRVRMTHALLAHYGLLAPAKMQVLRPLPARDRDLCRFHSDDYVAFLRAVTPETQFDQIRSLRRFNVGEDCPVFDGLYAYCQTYAGASVGAAVKLNHGTHDIAINWSGGLHHAKKSEASGFCYVNDIVLAILELLKLHERVLYIDIDIHHGDGVEEAFYTTNRVMTVSFHKFGDYFPGTGDIRDIGYSEGKYYCLNVPLDDGIDDDSYQSIFKPIISKVMEMYRPGAVVLQCGADSLSGDRLGCFNLSGKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGEELREKLPYNEYYEYFGPEYSLYVAASNMENRNTNKQLEEIKCNILDNLSKLQHAPSVQFEERIPETKLPEPDEDQDDPDERHDPDSDMLLDDHKPMGHSARSLIHNIGVKREITETETKDQHGKRLTTEHKVPEPMADDLGSSKQVPTADANSMAINAPGNAKNEPGSSL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.
What are the official names of this protein?
Histone deacetylase 2, OsHDAC2.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD Type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAH2_SHEEP
Sequence: MSHHWGYGEHNGPEHWHKDFPIADGERQSPVDIDTKAVVPDPALKPLALLYEQAASRRMVNNGHSFNVEFDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDVLDSIKTKGKSADFPNFDPSSLLKRALNYWTYPGSLTNPPLLESVTWVVLKEPTSVSSQQMLKFRSLNFNAEGEPELLMLANWRPAQPLKNRQVRVFPK
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide.  Involved in the regulation of fluid secretion into the anterior chamber of the eye.  Essential for bone resorption and osteoclast differentiation.  Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.  Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
What are the official names of this protein?
Carbonic anhydrase 2, Carbonate dehydratase II, Carbonic anhydrase II, CA-II.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity).
Protein: EAF6_KLULA
Sequence: MDEQKKEYEKLKKKLRDALVQKKQLEAKWNSLEQEVYDKETEYLSQKPSSRMGNILLGFQGFNKSSSAQQILSDHSHSSNAQPLDDNDRIFSLSSYLFAKQLAASNHQEQTKSND
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein EAF6.
What is the protein family that this protein belongs to?
Belongs to the EAF6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: WDR12_DROYA
Sequence: MDVENGEGQVQVHLKTKQEHYAVPDVPYAIDGTVTTVELNTFVNALLRQKDGSSDTDFDFLVFDEYLRGRLCDHLREKAISFEDAIEIEYVERFPAPEPQDCLLHDDWVSAVKASGKWILSGCYDNTLNLWTNKGKHILTISGHTAPIKAVDWISLDEETGRFVSTSQDQTAMLWQWNVGSNSVECVSVCKGHERGVDSVSVSPDGLRFATGSWDTMLKVWSAEVEDAVEGSSKRMKESGVRTPKITLQGHRESVSAVQWMDASTLLTGSWDHTLKVWDLSLEGIKTEISTNKSIFDASYSKLNRLILTASADKNLRLYDPRTNQGSVVRNTYLGHNAWVQTVMWSTTEEFLFVSGAYDNQNKLWDCRSPKAPLYDLLGHGEKVLDIDWSNPKYIVSGGVDNTVRVFKSRKALADDAETK
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein WDR12 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: TXDF1_DAFVA
Sequence: ECRWFLGGCSGGQTCCEHLVCHRKHQWCVWDWSF
What is the function of this protein?
Inhibits sodium channel Nav1. 7/SCN9A with high potency (IC(50)=117 nM) and Nav1. 2/SCN2A, Nav1. 3/SCN3A, Nav1. 6/SCN8A and Nav1. 5/SCN5 with weaker potency.  Also inhibits voltage-gated calcium channel Cav3. 1/CACNA1G, Cav3. 2/CACNA1H and Cav3. 3/CACNA1I.
What are the official names of this protein?
Mu-theraphotoxin-Df1a, Mu-TRTX-Df1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 54 (ProTx-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALLC_PSESM
Sequence: MKVYAAPFEKFVNLADARLGTKILSVTDDWFADANRLFQPTPAVWKEGVFDDNGKWMDGWESRRKRFEGYDSAVIKLGVAGTLKGVDIDTSFFTGNFPPSASLEACFLASGEPDENTAWTEVLSSVELKGNSHHYHEISHDQAFSHLRFNIYPDGGVARLRVYGVPHRDWSKVTESEQIDLVAALNGGRSIACSDEHYGSMSNILNPGRGVNMGDGWETARRRTPGNDWVIVALGHKGEVEKVIVDTLHFKGNYPDSCSIQGAFVKGGTDSQIETQSLFWRELLPSQKLTMHAEHEFAEQVKAIGPITHIRLNVFPDGGVSRLRVLGKVSR
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: NUOK_BURCH
Sequence: MLTLAHYLVLGAILFAIAIVGIFLNRRNVIIILMSIELMLLAVNTNFVAFSHYLGDVHGQIFVFFVLTVAAAEAAIGLAILVTLFRKLDTINVEDLDQLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNB_PARBP
Sequence: MSDIKDGNNDHLVQSDDPEHPANLIPALCRNFYSHGWVTGTGGGASIKRDNHIFIAPSGVQKELIQPHNIFVLSYPTPKYPPSARQYIRKPLKLNPSACTPLFLAAFERGAGCCIHTHSQWAVLVTLLVEREKGPEGCFEISNIEQIKGIPRGKGKGMMGFYDTLKIPIIENTAFEEDLTQSLEEAMEMYPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHRLGLPWVKS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.