PharMolix/UniProtQA huggingface dataset:
Protein: DDL_KOCRD
Sequence: MSTTHETPEATAEGDKPCIAVVFGGRSSEHSISLITARSVLRAIDRDRWDVVSVGISTDGAWFLCSQEELEALLDDQPMAQLPVGVHRVSLPLQTGDSRLLIHDTSEHGAPLSRGRHIDAVFPLLHGPFGEDGTLQGMLELADLPYVGCGVAASAIGMDKHFMKLAFQAAGLEVGPYTVVHDRTWRTDPLGVREAVAELGFPVFVKPARAGSSFGITRVDEPSQLDAAIATAREHDLKLVVEAGIDGREIECAVLGGHGTDEARASLPGEIEVHGHALYDFEAKYVESDGATLSCPARLPEHVIDTLRRDAVRAFHAVDGEGLSRCDFFVTADERVLINEINTMPGFTPISMYPRMWAASGIDYSALIDELITLALERPVGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSX_ASPCI
Sequence: MYNLKNQVIVITGSSSGIGLAASTIALSSGAKVFGVDIRPPPSTLTSQSNYACLQYDLSSSSTVSDIVAACEGAFGPRIDGLLNIAGVMDLNQSADTLADEIWERCIAVNLTAPVKLMREVLPVMQRQGGGSIVNVASKAALSGAVSGVAYTASKHGLVGATKNVAWRFKHERIRCNVVCPGGVGATSIRDGVDVTQFDAAALETMALIHQAHGCDREKGVELQPQDIAHMLLFLLDERSRGVSGAVIPVDNAWSTI
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Short chain dehydrogenase ausX, Austinoid biosynthesis cluster protein X.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MNHE1_STAS1
Sequence: MAIQILVNLILSVFWLFVTGSYNFNNFILGYLFALLLVYIMRGVLPGRFYLITVYKIIKLFLVFLIELIKANIDVIRIVVKPNIDNEPAFFTYNTDLKKDWQIVLLSNLITLTPGTIVLGISDDRTKIYIHSIDFSTKEEEVESIKSSLEKVVREVGENE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit E1, Mnh complex subunit E1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y138_MYCPN
Sequence: MKEKIPFYNEKEFNEMMKKTKKGTFSGWYIINPENKSVEFSGNFNRQFKLNKPVIPVNTEYVTRKEFNEYKDSNDQRLTKIENKVDKLEVKVDKLEEKVDKLEAKVDKLEEKVDKLEAKVDKLEEKVDKLEAKVDSGFEMLAKILAAINKRLDSIEGRLDKIEPPK
What are the official names of this protein?
UPF0134 protein MPN_138.
What is the protein family that this protein belongs to?
Belongs to the UPF0134 family.
Protein: MTNA_DROMO
Sequence: MSLQSIKYQRGSLEILDQLLLPVVSKYLPVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEIYPEEFSSKKSLRQEIEGKLNYLVSARPTAVNMKISADELITLANELTKDDAITVEEMKQRFLKATEAMLEKDIADNRAIGANGAKAILEHVAEATGVATAGPVRVLTHCNTGSLATAGYGTALGVVRNLSELGKLEHVYCTETRPYNQGARLTAYELVHEKLPATLVLDSMVAALLRVKNVAAVVVGADRVAANGDTANKIGTYQIAVVAKHHGVPFYVAAPLTSIDLEIPSGDHIIIEVRPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITEHGVFKPEALKVEITKLLEL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RPOC1_SPIOL
Sequence: MIDQYKHQQLRIGSVSPQQISAWATKILPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGDEKEDPKFCEQCGVEFVDSRIRRYQMGYIKLACPVTHVWYLKRLPSYIANFLDKPLKELEGLVYCDFSFARPIAKKPTFLRLRGLFEYEIQSWKYSIPLFFTTQGFDTFRNREISTGAGAIREQLADLDLRTIIDYSFAEWKELGEEGSTGNEWEDRKVGRRKDFLVRRMELVKHFIRTNIEPEWMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLTDLLSTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHLASNIGVAKRKIREKEPIVWKILQEVMQGHPVLLNRAPTLHRLGIQAFQPILVEGRAICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYILTSGNRRGICANRYNPWNHKTYQNERIDDTNYKSMKEPFFCNFYDAIGAYRQKRIHLDSPLWLRWQLDQRIIASKEAPIEVHYESLGTYHEIYAHYLIIRSVKKEIIDIYIRTTVGHISLYREIEEAIQGFYQACS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NB_STRAW
Sequence: MVDPAPEHPYPDGHRPDEAPAPHALLEPVLGLLGSWYGRGEGGYPTLTGDFGYAQELTFSHDGRPFLRYEARAWLLDADDAPLRPSARECGWWRLQPDGRVEALITQPTGIAEIMVGRATGNTIDLSTHEVALAPTAKKVNATRRRYTLTDDDTLTFHHDLEAVGQPMQHHLSARLRRRG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: BLA34_ECOLX
Sequence: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADGRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
What is the function of this protein?
Hydrolyzes ceftazidime and cefotaxime.
What are the official names of this protein?
Beta-lactamase SHV-34.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: SC10_MESMA
Sequence: MNYLVMVSFALLLMTGVESVRDGYIALPHNCAYGCLLNEFCNDLCTKNGAKIGYCNIQGKYGNACWCIELPDNVPIRVPGRCHPS
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Toxin BmKaTx10, Alpha-neurotoxin Tx10, BmKalphaTx10, Toxin KT2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SFGH2_ECOLI
Sequence: MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPDTSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWGIKAFSSYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAARQKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate.  Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids.
What are the official names of this protein?
S-formylglutathione hydrolase YeiG, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: ZNTB_SALPC
Sequence: MEAIKGSDVNVPDAVFAWLLDGHGGVKPLEDNDVIDSQHPCWLHLNYTHPDSARWLASTPLLPNNVRDALAGESSRPRVSRMGEGTLITLRCINGSTDERPDQLVAMRLYMDERFIVSTRQRKVLALDDVVSDLQEGTGPVDCGGWLVDVCDALTDHASEFIEELHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDHRRRMQDIADRLGRGLDEIDACIARTGIMADEIAQVMQESLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWRFGFSLFCILLVVLIGGVTLWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KLK1_HUMAN
Sequence: MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
What is the function of this protein?
(Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa.
What are the official names of this protein?
Kallikrein-1, Kidney/pancreas/salivary gland kallikrein, Tissue kallikrein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein: AFP4_MYOOC
Sequence: MKFSLVATIVLLALAQGSFAQGAADLESLGQYFEEMKTKLIQDMTEIIRSQDLANQAQAFVEDKKTQLQPLVAQIQEQMKTVATNVEEQIRPLTANVQAHLQPQIDNFQKQMEAIIKKLTDQTMAIEN
What is the function of this protein?
Antifreeze proteins lower the blood freezing point.
What are the official names of this protein?
Type-4 ice-structuring protein LS-12, ISP LS-12, Antifreeze protein LS-12.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMJ_SYNY3
Sequence: MPKREYFSLPCPLSTFTMAYYWFKAFHLIGIVVWFAGLFYLVRLFVYHAEADQEPEPAKTILKKQYELMEKRLYNIITTPGMVVTVAMAIGLIFTEPEILKSGWLHIKLTFVALLLLYHFYCGRVMKKLAQGESQWSGQQFRALNEAPTILLVVIVLLAVFKNNLPLDATTWLIVALVIAMAASIQLYAKKRRRDQALLTEQQKAASAQN
What is the function of this protein?
Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.  Is involved in the biosynthesis of tetrapyrrole molecules like heme and chlorophyll.  Does not use oxygen or artificial electron acceptors such as menadione or benzoquinone.  Is functionally coupled with coproporphyrinogen III oxidase (CPO) (PubMed:29925590).  Is essential for growth (PubMed:20823222).
What are the official names of this protein?
Protoporphyrinogen IX oxidase, PPO, Protox.
What is the protein family that this protein belongs to?
Belongs to the HemJ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURB_SYNJA
Sequence: MTTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQGIPVTLLGAGSNLLISDAGLPGLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRGWSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILDEEQEPCRLEPVDLQFGYRRSRLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAGWLIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEVRILGSFDDPLIS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_ALIFM
Sequence: MYAVFQSGGKQHRVSEGQTLRLEKLDVETGATVEFDNVLMIANGEEITVGAPLVAGGKVTAEVVQHGRGDKVKIVKFRRRKHSRKQQGHRQWFTEVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SYA_BACLD
Sequence: MKTLTSAQVRQMFLDFFKEKGHAVEPSASLIPHEDPSLLWINSGVATLKKYFDGRVVPENPRICNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAIEWAWEFLTDQKWIGFDPERLSVTVHPEDDEAYELWSKKIGIPEERIIRLEGNFWDIGEGPSGPNTEIFYDRGEDYGNDPSDPELYPGGENERYLEVWNLVFSEFNHNPDGTYTPLPKKNIDTGMGLERMVSVIQDAKTNYDTDLFMPIIKATEAISGEKYGTSAEKDTAFKVVADHIRTAAFAVGDGALPSNEGRGYVIRRLLRRAVRYAKSININRPFMYELVPVVADIMAAFYGEVKEKADFIAKVIKTEEERFHETLHEGLAILSEVIQKEKAKGNRIISGEDVFKLYDTYGFPVELTEEYAEDEGMEVDHEGFEREMDKQRERARQARQDVGSMQVQGGALRDIMTESEFIGYSDIKTETKIAELLQDGELVDLVQEGQKVQFILEKTPFYAESGGQIGDKGWVKSGDAAIRVTDVKKAPNGQHLHEGIVESGAIKKGMSVTAEVTERLRKDIVKNHTATHLLHQALKDVLGTHVNQAGSLVTDSRLRFDFSHFGQVTKEELEQIETKVNEKIWASIPVQIDLKPIAEAKAMGAMALFGEKYGDIVRVVQVGDYSIELCGGCHVRNTAEIGLFKIVSESGIGAGTRRIEAVTGQGAYEEMNAKLELLEQAAEVLKTNVKEVPKRIEALQSDLKDAQRENESLLAKLGNKEAGEILEKVKEIDGIKLLAEKVNAKDMNHLRTMVDDLKAKLGSAVIVLGAVQNEKVNISAGVTKDLIERGFHAGKLVKQVAEACGGGGGGRPDMAQAGGKQPERLAEALASAEEWVKSVL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_BACMK
Sequence: MFKHVTVLLKETVDGLDIKPSGTYVDCTLGGGGHSSYLLSQLTDGGKLIAFDQDEIAIQNAKEKFSSYGEQFVTVKSNFRYLSEKLHELGITEVDGILFDLGVSSPQLDTPERGFSYHHDAPLDMRMDQDAPLTAYDVVNSWSYEQLVRIFFQYGEEKFSKQITRKIEAYRENKAIETTGELVELIKEGIPAPARRTGGHPAKRVFQAIRIAVNDELKVFEEALESAIDMVKPGGRVSVITFHSLEDRICKTTFKRNSTTPQLPQGLPIIPDEFKPKLKLITRKPILPSDIELEENNRARSAKLRIAEKR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_NOCFA
Sequence: MSEADVTARGDAALLGPAEVRALAERFGVRPTKQLGQNFVHDANTVRRIVTAAGVGRADTVLEVGPGLGSLTLALLDVVDSVVAVEIDPVLAEHLPRTVADRAPALAGRLRVVRDDALRVRAADLPASPTALVANLPYNVAVPVLLHLLAELPGLRTALVMVQAEVADRLAAEPGSRVYGVPSVKAGFFGTVRRAGAVGTQVFWPVPRVESGLVRVERYVEPPWPMDEQHRRRVFEIIDAAFAQRRKTLRAALAGWAGSPAEAERRLLAAGIDPTARGETLDTAAYVRLAAQA
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFL2_PHOSM
Sequence: MEHNTDISTTQYNSHTVSTTTLSSFLVNVVTSSKRGNKMTTITAQPPRDEVEPAVPAPQLLSSDSASELSPKAEKFQPGWRFIAAFLSLCIIVLMAALDATSISVALPSMARALGGSAIEAFWAGTSFLLTSTIFQPVLGSFSHIFGRKSLIYISLVFFLAGSIIPAVANNFTTILVGRSIQGVGGGGIIALTEMVVVDTVPLRERGKWFSFFGMMWSFGTVAGPLIGGAFAQKVSWRWVFWINLPFLGIGTVLITVFLKLNQRHGEFLARLREVDWIGMVLFLGSTTGFLIPITWGGVQYPWDSWRTLVPLIVSAAGIVAFIVHQEKFAPHPLIRTSVFKNKSAALLYLTTVIHGIILWAILYFMPLYFEAVKGMGPIMAGVALFPWTFTVAPGAVATGIAIAVTGKYRWANWAGWFLATLGSGLLILLKPDTSTPAWIFLNLVGGIGTGILFPAMALAVQASASVKDQAYAANMFSFFRAFGQTLGVAIGGVVFQNQMKAKLLTYPLLADMADTYSKDAAGLVEIIKGMPAGLMKDQLKESYTDALKYIWIVATVLAGVSLVATLFIDEFDMDIEMDTERGFKEKSKVKDAEKETH
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a lead compound for the treatment of hyper-cholesterolemia by targeting squalene synthase (SS).
What are the official names of this protein?
MFS transporter L2, Squalestatin S1 biosynthesis cluster protein L2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZIPA_ALIF1
Sequence: MQELRLVLILVGALAIAALLFHGLWTSRKETSSKFGKKVDIDFDSDVDDEQAAPMRGFDQPKEDVVVQKERKEPAFAREEVPTSDDPLFEGTVSSESNKFTQQEKPTVQQAQPQPQPQPVVQQVQEPTVGRIEPEAKPVAAPVKREEPTISFSAIDDEVLTQPEPVQAKVDIPETSTYLEPEIIIEEPEPEPEPELEEDVIVINVHGMGSDRFSGNRLFNSLEQNGLVFGDMAIYHRHSDLSGAGKVLFSVANMVSPGHFQVPEGEEFSTPGISFFLPLPCYGDAEHNFKLMLQTAQMISSELGGNVLDEKRDMLTPNKIDEYKQRVKVFCRK
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: IGSF3_HUMAN
Sequence: MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTMDSSFPYAIYTQRVRGGKIFIERVQGNSTLLHITDLQARDAGEYECHTPSTDKQYFGSYSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLELTCEVASETIQHSHLSVAWLRQKVGEKPVEVISLSRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPVEFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREARGQLKVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIIVLPLKSSISVEVASNASVILEGEDLRFSCSVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWERSSFGGVQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTPISITALEMGFAVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETRQVQLECVVLNRTSITSQLMVEWFVWKPNHPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALTVMRPDASLQVDTVVPNATVSEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEEREEEEEEDDDDDDDPTERTALLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSPTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID
What are the official names of this protein?
Immunoglobulin superfamily member 3, IgSF3, Glu-Trp-Ile EWI motif-containing protein 3, EWI-3.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: EFG_STRA5
Sequence: MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWDGHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDAQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVQSLHDRLQANAHPIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYVDQANEYREKLVEAVADTDEDLMMKYLEGEEITNEELMAAIRKATINVEFYPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDEEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLNSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEKSKVILESIEVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMKREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLALKEAAKSAQPAILEPMMLVTITAPEDNLGDVMGHVTARRGRVDGMEARGNTQVVRAFVPLAEMFGYATVLRSATQGRGTFMMVFDHYEDVPKSVQEEIIKKNSGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKF_ECOLU
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLSQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.