PharMolix/UniProtQA huggingface dataset:
Protein: TRMA_PSEA8
Sequence: MSRPQFDPSAYAAQLEDKKSRLAGLLAPFAAPAPEVFESPREHYRLRAEFRLWRETGNEKRHYAMFEQGDKHTPILIEDFPIASRRINELMPRLKAAWADPALGFKLFQVEFLTTLAGDALITLCYHRPIDDAWRQAAEKLAAELGVNLVGRSRGKRIVVGRDYVEEELSVAGRRFRYRQPEGAFTQPNGEVNQKMLGWAYEALGQRDDDLLELYCGNGNFTLPLATRVRKVLATEISKSSVNAALANLADNAVDNVSLVRLSAEELTQALNEVRPFRRLADIDLKSYAFGSVFVDPPRAGMDPDTCELARRFERILYISCNPETLAQNIAQLHDTHRISRCALFDQFPYTHHMESGVLLERR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: FOLD_COREF
Sequence: MTAIKLDGNLYRDEIFADLAQRVAALKEKGIVPGLATVLVGDDPASHSYVKMKHRDCEQIGVNSIRRDLPADISQEELFAVIDELNADDSCTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPVNLGKLVLNEPAPLPCTPNGSISLLRRFGIELNGAKVVVIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETRAADVIVAAAGQPHMLTADMVKPGAAVLDVGVSRKDGKLLGDVHPDVWEVAGAVSPNPGGVGPLTRAFLVHNVVERAEKLAGL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL15_SHELP
Sequence: MKLNTLSPAAGAKSAAKRVGRGIGSGLGKTAGRGHKGQKSRSGGGVRVGFEGGQMPLKIRLPKFGFTSRKAMVTAEIRVSELAKVNGDVVDLNALKDANLVTRNIQFAKVVLSGTIERPVTVKGLKVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL19_RHOPT
Sequence: MNLIQTLEKEQFDKLSAGKTIPEFGPGDTVIVNVKVVEGERSRVQAYEGVCIGRSGGGINESFTVRKISYGEGVERVFPLLSPMIDSIKVVRRGKVRRAKLYYLRNLRGKSARIVEKKQDRTAAVAAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SLYA_EDWI9
Sequence: MESTLGSDLARLVRVWRALIDQRLKPLELTQTHWVTLYNIHRLPPEQSQIQLAKAIGIEQPSLVRTLDQLEDKGLITRHTCANDRRAKRIKLTDGAEPVIREVADVISLTRCEILDGISADEVSLLANLIERLEQNIIHLQNK
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: LEUC_NEIG1
Sequence: MTAQTLYDKLWNSHVVREEGDGTVLLYIDRHLVHEVTSPQAFEGLKMAGRKLWRIDSVVSTADHNTPTGDWDKGIQDPISKLQVDTLDQNIKEFGALAYFPFMDKGQGIVHVMGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHTMATQCITAKKSKSMLIAADGKLKAGVTAKDVALYIIGQIGTAGGTGYAVEFGGEAIRSLSMEGRMTLCNMAIEAGARSGMVAVDQTTIDYVKGKPFAPEGEAWDKAVEYWRTLVSDEGAVFDKEYRFNAEDIEPQVTWGTSPEMVLNIGGKVPNPAEETDPVKRSGIERALEYMGLKAGTPLNEIPVDIVFIGSCTNSRIEDLREAAAIAKGHKKAGNVQRVLIVPGSGLVKEQAEKEGLDKIFIEAGFEWREPGCSMCLAMNADRLAPRQRCASTSNRNFEGRQGNGGRTHLVSPAMAAAAAVTGHFTDIRTMA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MPRIP_MOUSE
Sequence: MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEARTGQKFSLCILTPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKMAVTSSSGGSSGSSSSIPSAEKVPTTKSTLWQEEMRAKDQPDGTSLSPAQSPSQSQPPAACTPREPGLESKEDESTISGDRVDGGRKVRVESGYFSLEKAKQDLRAEEQLPPLLSPPSPSTPHSRRSQVIEKFEALDIEKAEHMETNMLILTTPSSDTRQGRSERRAIPRKRDFASEAPTAPLSDACPLSPHRRAKSLDRRSTESSMTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEINLSTCYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVLPASAPDVTSSLPEGKNKSTSFETCSRSTEKQEAEPGEPDPEQKKSRARERRREGRSKTFDWAEFRPIQQALAQERASAVGSSDSGDPGCLEAEPGELERERARRREERRKRFGMLDTIDGPGMEDTALRMDIDRSPGLLGTPDLKTQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSLEDRSERLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSINSDIEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGESTGLPLTQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPEGTTVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVSWDN
What is the function of this protein?
Targets myosin phosphatase to the actin cytoskeleton.  Required for the regulation of the actin cytoskeleton by RhoA and ROCK1.  Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin.  Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
What are the official names of this protein?
Myosin phosphatase Rho-interacting protein, Rho-interacting protein 3, RIP3, p116Rip.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
Protein: 3DHQ_ASPOR
Sequence: MGKSILLINGPNLNLLGTREPHIYGSTTLADVEASSKAHAASLGATLETYQSNHEGAIVDRIQAARGNVDGIVINPGAYTHTSVAIRDALVGVDIPFIELHVSNVHAREPWRHHSYFSDKAAGIIVGLGVYGYKVAVEHVAVNFKSREEKAAL
What is the function of this protein?
Is involved in the catabolism of quinate.  Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
What are the official names of this protein?
Catabolic 3-dehydroquinase, cDHQase, 3-dehydroquinate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: THIQ_BRUME
Sequence: MTASADIRLSDVRFSYGETAMHFDVTITGGEIAAIVGPSGSGKSTFLNLIAGFETPQSGIISINGVDVTHLPPADRPVSMVFQENNLFAHLTVEQNVDLGRSPNLRLNEEDRKAVASALARVGLQGKEKRKPEALSGGERQRVAIARVLVRERPVLLLDEAFASLGPALRHQMLDLVNKLRRETGMTVLMVTHTPEDALHLDALLIFLDNGKIAAQGPATEMLSRAGPEALRHYIGEMRSF
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Thiamine import ATP-binding protein ThiQ.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KPRS2_STRP1
Sequence: MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSNGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERYSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKILERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERRPLSPLFSYQPKGKNNA
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Putative ribose-phosphate pyrophosphokinase 2, RPPK 2, 5-phospho-D-ribosyl alpha-1-diphosphate synthase 2, Phosphoribosyl diphosphate synthase 2, Phosphoribosyl pyrophosphate synthase 2, P-Rib-PP synthase 2, PRPP synthase 2, PRPPase 2.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_CAUVC
Sequence: MADDATTARDYRETVFLPDTPFPMRAGLPKKEPEILEGWAALSEKGLYGAVRQKRQAAGAPLFVFHDGPPYANGAIHIGHALNKILKDFVVRSRFALGYDVDYVPGWDCHGLPIEWKIEEQFRAKGRRKDEVPAEEFRRECRAYAGGWIEAQKTEFQRLGVLGDWWNRYATMDFTSEAKIVEEFHKFLATGQLYRGSKPVMWSPVERTALADAEIEYHDHVSPTIWVKFPVVQGSDAAVGAKLVIWTTTPWTIPANRAVSYNPDIPYSVFEVTALEEGLEFEPWAKPGDRLIIADKLAEDVFKAAKVASWKTVEAVDCEGMVLAHPLADLDSHYGYAVPMLAGDHVTDDAGTGFVHTAPGHGADDYQVWLAHGHREIPDTVDPDGAYYPHVALFAGLKVLETEGKKVGKFGPANGAVMEKLIEAGNLLARGRVEHSYPHSWRSKAPVIFRNTPQWFIRMDHAVDSLDGKTLREVAVQAIADTAFYPDGGRNRIGAMVETRPDWLISRQRNWGTPLAMFVDKHTGHPLNDPEVNARILAAIREGGADAWFTRPDADFLGAHDPAQYEKITDILDVWFDSGCTHAFTIEGRADSAWPADLYLEGSDQHRGWFQSSLLEGCGTRGRAPYKAVVTHGFTMDENGEKMSKSRGNTIEPQTITKESGAEILRLWTAMVDYQEDQRIGKTILATTTDAYRKLRNTMRYLLGALAGFDEEERVTDYDQFPALEKYILHRLWELDGQVREAYQSYRFSDVIRPLIEFCQGDLSALYFDVRRDSLYCDRPDALKRRAYRTALDYVFDRLTIWLAPLASFTMEEAWTTRFPEAGPVAYRVMPERVDAWRNDAEAARWAKVEKVTSVVTGALEVERREKRIGSALEAAPVVHFADEDLLAAFEGLDAGEVFRTSSATLVAGDAGAFRVDEVKGVSVDPNKAEGKKCARSWRILPEVGTDPRYPELSLRDADAVAYWDAGRG
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_CHLCV
Sequence: MTSKKPTPMMKQWHQCKEQAGESLLLFRMGDFYEAFYDDAVLLSQNLDINLTQRQGIPMSGIPVSTVNGYIDRLVSKGFKVAIAEQIEEAQNNKGKSEPLARELQRFVTPGTLLSSSLLPEKANNYIVSIYRVGSLFGFSCLDFSTGAFLLNEYDNMKDLIDEICRLAPTEILSCDKFYKKHFEIVEQIQQHLKLTLSTYSDWAFEHQFATQKLSSHFNVSSLDGFGLKGLVPAINAAGALLSYLQDKLLLPVEHISVPKTHGNQKHLLIDTASQVNLELLTPIHDPQGKSSLLHVMERTCTPMGGRLLRNTLVNPFYDQKEILLRQDAVEFLLNRSELRKNLRSFLSQVRDLERLTTKITTALAGPKDIGMLRDSLNASMHICEILSPLPLPEFFHGKFTLGLGLASLLELLSKALFGELPLRISDGNIFSDDHHPDLKRLRYTRENSKEWLWQYQDAIRTQTGVKKLKVCYSQVLGYYIEVSSDLAPLLPKDFIRRQSRLHAERFTTEKLQEFQDDMLNVSDKLQTLETQLFKDLCAQILEQRDAILSLSQVIADTDYILSLADLAAEYGYCRPIVDTSDSLSITGGMHPVAQTLLDRGTFIPNDIKMHSARTRMILITGPNMAGKSTYIRQIALLIIMAQMGSFIPARSAHIGMIDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSLIVLDEVGRGTSTYDGLAIAQSVVEYLLFTEGKKAKTLFATHYKELTDLENHCPHVENFHAGVRENGGHPVFLYEILKGHSQKSFGIHVAKLAGFPLCVISRAQQILRQLEGPETTSKQTQEKVQQLTLF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RL16_SHEB2
Sequence: MLQPKRMKFRKMFKGRNRGLANGTEVSFGTFGLKAVGRGRLTARQIESARRAMTRHIKRQGQIWIRVFPDKPITSKPLEVRMGKGKGNVEYWVCQIQPGKVLYEMNGVSEVIAREAFALAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: TRHO_BURM9
Sequence: MTTVNLAAYRFVSLDSIEQWRPLVAARCNTLGLRGTILLAPEGINLFIAGPREATDAFVDYIRHDPLFEGKFADLPFKESLSDSQPFRRMLVRLKREIITMKKPAIKPELGRAPSVDARTLKAWLDQGHDDAGRPVVMLDTRNAFEVDVGTFDRALDYRIDKFSEFPAVIEANRADLEGKTIVSFCTGGIRCEKAAIHMKDVGIENVYQLEGGILKYFEEVGGAHYHGDCFVFDYRTALNPQLAPTADVTCFACRAVVPADAQQSPLYVPGKCCPACHPGDSGTPGRRAEPGAEPARAV
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RK22_CUSRE
Sequence: MRKTKAPEIYALGQHISMSADKARRVIDQIRGRSYEETLMILELMPYRAAYPILKLVYSAASNASYTLDSNEANLFISKAEVNQGPAIKKLKPRARGRSYPIKRPTCHITILLKDISFYDSDSESVELNLLKKAR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid.
Protein: MRAZ_SHEVD
Sequence: MFRGASAINLDTKGRIAIPKRYREPLRAEYNGQLVITVDFQSSCLLLYPLDEWSKIEAKLLLLSDTRASERAMKRLLLGYAHECELDGNGRLLLPPPLRQYANLEKHAMLVGQLNKFELWDEAAWQQQIEQSRETIRSEEFASNERLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: LPXH_AZOVD
Sequence: MTTLLISDLHLDEERPDIARAFLRFLKERASQAEALYILGDFFEAWIGDDAMTSFQRDIAAALREVAERGTRVFLMHGNRDFLVGHSFCRQAGCTLLRDPSRVILNGAPVLLMHGDTLCTRDIAYMRFRRRLRNPVSVWLLRHLPLSKRRQLARKWRDASRMQVRRKATEIVDVTPEEVPRIMAAHGVLTLIHGHTHRPAVHELQVDGRQARRIVLGDWNRQGWVLQVDGSGYHLTPFPID
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GREA_STRSV
Sequence: MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDLSENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAKDEVAIGKTVTIQEVGESEEEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATVETPVGSYDVKILKVEKTV
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRPD_META3
Sequence: MLNKIINREDLSYEESYDLFNDLLNESEIKIGAYLSALQTKGFTANEIAGFAKAMRDNAIAIDLGKGISDTCGTGGDGYSTINISTAVSIILSCFTKVAKHGNVSITSKSGSANVLDALNIKKDCNPEEAKKMIDKTNFVFLFAPNYHPALKKIMPVRKELGIKTIFNILGPLANPANPDYQIMGVNSLDLVEKVGDALKLLGVKKALVVYGNGLDELNPNDYSTICEINENEENKIYKIHPKDIGLTPSNPIPCNSPDESAKRIIKIFSGTINEDRDFILLNAAAALYASNIAKDYKEGLKLAKEVIDNGTVLKKLKEIQKYGE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TSAD_FERNB
Sequence: MIVLGIETSCDETSVALVEDNTVIANLVYSQIQIHKKFGGVVPEIAAREHLKRLPILFSELISQTNINIERIDGIAVTKGPGLIGALLVGVSFAKGLALRYKKPLVGINHIIGHVYSNYLAYPDLKPPYIVLMVSGGHTLILKVEENNNVTILGRSVDDAVGEAFDKIARLLGLGYPGGPEIDKISKNGNPNAFNFPKPKMYDPDYNFSFSGLKTAVLYEIKRLTKSGYSENNLPIPDLAASAQEVMIDVLLHKVTKAARDNNLKNIVLAGGVAANSRLREKIRALSEEFNFYIPPLEYCSDNAAMIARAGLERIKSGENDGLNFEPVPNFFEMMST
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_BRUSU
Sequence: MSKHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGGIDKGEDPAQAALRELYEETGMTSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFAYRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVPFKRKVYEQVVATFRHLAA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: EXBD2_XANCP
Sequence: MAFSTGGNRGPMADINVTPLVDVMLVLLIIFIVTAPIMTYPIAVDLPQRVLNPPPQTTEPPPPIELRIDASNQVFWNNSPTPVAQLQQKMEEVVQADPTNQPELRIDANEDAEYEVMAKVLAAAKNSQMKKIGFMQ
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
What are the official names of this protein?
Biopolymer transport protein exbD2.
What is the protein family that this protein belongs to?
Belongs to the ExbD/TolR family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: TAL_PSEAB
Sequence: MTSKLEQLKQYTTVVADTGDFDAIARLKPVDATTNPSLLLKAAALPRYAEHLRQATAGSGGDAGLACDRFAVAVGKDILGVIPGRISTEVDARLSFDSEATLARAHRLIELYDEQGIDRERVLIKIASTWEGIRAAEILEREGIQTNLTLLFSFAQAVACADAGVFLISPFVGRIYDWYKKSENRDYAGAEDPGVQSVSRIYRYYKANGYKTVVMGASFRNLGQIEQLAGCDRLTISPDLLQQLADAQGELPRLLLPGEGEPRQVLDESAFRWQMNEDAMATEKLAEGIRLFARDQEKLEYQLATRH
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARMET_DROGR
Sequence: MNTSQIVLMFCLVVGVAQTALALKEDDCEVCVKTVRRFADTLDDATKKDYKLIEADFKKFCKTQKNKEQRFCYYLGGLEESATGILNELSKPLSWSMPAEKVCEKLKKMDAQICDLRYDKQIDLNNVDLKKLKVRDLKKILNDWDENCEGCLEKSDFIKRIEELKPKYTRSEL
What is the function of this protein?
Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity.  Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor homolog, MANF/CDNF-like protein.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted.
Protein: NQOR_YERP3
Sequence: MAKILVLYYSMYGHIETLAGAIAEGARKVSGVDVTIKRVPETMPAEAFAKAGGKTNQQAPVATPHELADYDGIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKVASVFASTGTGGGQEHTITSTWTTLAHHGFIIVPIGYGAKELFDVSQTRGGTPYGATTIAGGDGSRQPSAEELAIARFQGEHVAKITAKLKG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: 1433E_CHICK
Sequence: MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.
What are the official names of this protein?
14-3-3 protein epsilon, 14-3-3E.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: IL10_VULVU
Sequence: MPSPALLCCCLVLLAGVGASRHQSTLSEDDCTHFPASLPHMLRELRAAFGRVKTFFQMKDKLDNILLTGSLLEDFKGYLGCQALSEMIQFYLEEVMPRAENHDPDIKDHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKSAFSKLQEKGVYKAMSEFDIFINYIETYMTMRMKI
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DUT_MYCVP
Sequence: MPTTLAVVRLDRDLPLPSRAHDGDAGVDLYSAQDVELAPGQRALVPTGIAVAIPHGMVGLIHPRSGLAARVGLSIVNSPGTVDAGYRGEIKVSLINLDPAAPIAIRRGDRIAQLLVQRVELPELVEVTSFDEAGLADTTRGDGGHGSSGGHASL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ETS1_HUMAN
Sequence: MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE
What is the function of this protein?
Acts as a dominant-negative for isoform c-ETS-1A.
What are the official names of this protein?
Protein C-ets-1, p54.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.