PharMolix/UniProtQA huggingface dataset:
Protein: THIQ_YERPA
Sequence: MLKLEKITYLYDHLPMCFDLRIQPGERVAILGPSGAGKSTLLSLIAGFLAPTGGHMLLNNQDHTASTPAQRPVSMLFQENNLFAHLTVEQNIGLGLHPGLKLSGEQRLLLQHIAQQVGLESCLDRLPAQLSGGQRQRAALARCLVRSQPILLLDEPFSALDPALRNEMLQLVDQVCINRQLTLLMVSHNLDDAARIAQRTLLIVEGRIDYDGPTQALVDGSAAKASVLGIKSAVIS
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Thiamine import ATP-binding protein ThiQ.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NDOR1_CRYNB
Sequence: MIPMILYASETGNAQDTAERVARAFRANGRAVTCLPMDQFPISALPHTYLLILLTSTHGRGDPPPAMLPLWTALLRSSLPEDILEDVHFALFGLGDSSYERFCYAGKMLLRRMEQLGATKMGEPAWGDERSPNGIEDAFLPWLQQTLDLYLPYLPLISPTPKIIESTVLPPPIYKISPASTSKSVEHDLSLERLSISFPIPNGKPAPVRVEDQARDKASTSRTKPDDWVWATLKKNIRLTSKDWWQDVREIELEFDDPDTKPYTAGSICSLQPQSREDDVNMFLEMMELTSQADEVVTIESLLDEQPLPSHLPPAGTPTTLRSLLTNHLDIRYSPRKSFFEWLRRLSTNEMERERLDEFISDPDEIHTYATRPSRTIVETLADFRFTRIPMSHILEILPPLRRRQFSIASSWEDHPGKVQLLVALIEYKTNLKIPRKGLCSSWLNGLPVGTRIPIHIASPTLFLPQDPEVPIILVGPGTGVAPMRAFVEIRVRQGAAKNTSLYFGCRSSTTDYFFESEWDVHREKGVKIQVAASRDQEERIYVQHLIKRDKEYVKEWIVDKKGWLFISGSSNAMPREVREAVAWCISKEGAGDMTEEESKAYVEQMFEDKRGGEESW
What is the function of this protein?
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery.  In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.  Positively controls H(2)O(2)-induced cell death.
What are the official names of this protein?
NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Protein: RBL_ADICA
Sequence: MSPQTETKAGVGFKAGVKDYRLTYYTPEYKTKDTDILAAFRMTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQYIAYVAYPLDLFEEGSVTNMLTSIVGNVFGFKALRALRLEDLRIPPAYSKTFLGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKSQAETGEIKGHYLNATAGTCEEMMKRAVFARELGAPIVMHDYLTGGFTANTSLAFYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVFPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEIWKAIKFEFETIDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIPA_FLAJ1
Sequence: METVIENIPPAKPKWLKVKLPIGQKYTELRGLVDKYSLNTICTSGSCPNMGECWGEGTATFMILGNVCTRSCGFCGVKTGRPETVDWDEPEKVARSIKIMNIKHAVITSVDRDDLKDGGSIIWMETVRAIRRMNPNTTLETLIPDFQGIERNIDRIVEANPEVVSHNMETVRRLTREVRIQAKYDRSLEVLRYLKEKGINRTKSGIMLGLGETEEEVYQTMRDLRDANVDVVTIGQYLQPTKKHLPVKEFITPELFAKYEKYGIELGFRHVESGPLVRSSYKAQKHIL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_MYCTO
Sequence: MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UREG_BURTA
Sequence: MHAPHTATALRRTKKLPPLRVGIGGPVGSGKTTLLEMLCKGMRERYDLVAITNDIYTKEDQRLLTIAGALPEERIMGVETGGCPHTAIREDASINLEAVERMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLDVMASDTKKMRGERPYVMCNLKALDGVADVIAFIEKKGLLTV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG48_ALHV1
Sequence: MELPVPVAILTSNQQTKWRLLIASFSSHKNTQACLNFLRGTFCKTDDCYCAGLLVLVSLIQTEDNMIEKDRVIQMAILVRSLAEYCFDEIFQRVYPENIESMFTECSRRLALLLECECGCMECLETVKGLQKAQISYRMPRLNPHEISSYEFTLSSVYNSAVLCNSVPVSKDLLRDIVMGSHFEGGFSIEAKKEASLLAICITFCWLFYKMQQTVTGALEDIFEDMMQFAVTYKIPLESKRDLCRLDVRLLKKIKERGAFMGGNKNVVKFPIAAGTSLYKQLSAYKRQLIGDRCPFDPDYENLKKMIQDSAGLFTQTPPCTEEGSPPDITVQECQSESVGSPDKGEGDCPHPINTSPCLKQVSEQHLLALDALLAESSSCPETQTSLSGVNSDEYLSDPEVTSENYLTLEEFERKINLL
What are the official names of this protein?
Uncharacterized gene 48 protein.
Protein: MDHC_CANAL
Sequence: MVKVAILGAAGGIGQPLSLLTKLNPNVDELALFDVVNVPGVGADLSHINSDSKTQSYLPKDKEDKTALAAALKGSDLVIIPAGVPRKPGMTRDDLFNINASIVQGLAEGIAANSPKAFVLVISNPVNSTVPIVAETLQAKGVYDPARLFGVTTLDIVRANTFISQLFLDQTKPSDFNINVVGGHSGETIVPLYSLGNSKQYYDILSEEQKKELIKRVQFGGDEVVQAKNGAGSATLSMAYAGYRLAESILAAVNGKTDIVECTFLNLDSSIKGASEARKLVKDLDFFSLPVQLGKNGITEVKYDILNQISDDEKKLLEVAIEQLQKNIEKGVSFAKK
What are the official names of this protein?
Malate dehydrogenase, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2352_MYCBO
Sequence: MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS
What are the official names of this protein?
Uncharacterized protein Mb2352c.
What is the protein family that this protein belongs to?
Belongs to the CbiQ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1921_LISMO
Sequence: MKASISIDEKKDFIRWFLNKHQMKTREAMWVLNYIAGHDQIVKYVHFVDNLEGCARGLSLSAHGVESEPFLFFKGNIMTTDPEKAFHDIRLNWDEELYVELHFEEAMSSPEYALVREDNPFAAVKLADEEKEMADALIYQSVHQFSREKVLQQIDEALDTRDEAAFHKLVRILQQMDTEKE
What are the official names of this protein?
UPF0302 protein lmo1921.
What is the protein family that this protein belongs to?
Belongs to the UPF0302 family.
Protein: INS2_CONTU
Sequence: MTTSFYFLLVALGLLLYVCQSSFGNQHTRNSDTPWNRCGSQITDSYRELCPHKRNDAGKKRGQASPLWQRGGSLSMLKARAKRNEAFHLQRAHRGVVEHCCKRACSNAEFMQFCG
What is the function of this protein?
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:30747102).  It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (INSR) and assembly of the hormone's hexameric storage form (By similarity).  Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=15. 5 nM) (PubMed:30747102).  In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with a lower potency than human insulin (PubMed:30747102).  In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency (By similarity).  When tested on a mouse model of diabetes, this insulin also lowers blood glucose with a 10-fold lower potency than human insulin (By similarity).
What are the official names of this protein?
Con-Ins T2, Insulin T2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS14_RUEST
Sequence: MAKKAMIEREKKRERLVAKYAAKRAELKEIANDESRPMEERFKARLKLAKLPRNSSATRLHNRCQLTGRPHAYYRKLKVSRIALRELGSNGQIPGMVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: GNB5_PONAB
Sequence: MATEGLHENETLASLKSEAESLKGKLEEERAKLRDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
What is the function of this protein?
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable).  Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity).  May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-5, Gbeta5, Transducin beta chain 5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
What are the subcellular locations of this protein?
Membrane.
Protein: SNF3_YEAST
Sequence: MDPNSNSSSETLRQEKQGFLDKALQRVKGIALRRNNSNKDHTTDDTTGSIRTPTSLQRQNSDRQSNMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSHVAPNHDSFTAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVGAGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHARNDASSYRIPIGLQYVWSSFLAIGMFFLPESPRYYVLKDKLDEAAKSLSFLRGVPVHDSGLLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYYGVNFFNKTGVSNSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIVAIVGCSLKTVAAAKVMIAFICLFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFICALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDELYIKSSTGVVSPKFNKDIRERALKFQYDPLQRLEDGKNTFVAKRNNFDDETPRNDFRNTISGEIDHSPNQKEVHSIPERVDIPTSTEILESPNKSSGMTVPVSPSLQDVPIPQTTEPAEIRTKYVDLGNGLGLNTYNRGPPSLSSDSSEDYTEDEIGGPSSQGDQSNRSTMNDINDYMARLIHSTSTASNTTDKFSGNQSTLRYHTASSHSDTTEEDSNLMDLGNGLALNAYNRGPPSILMNSSDEEANGGETSDNLNTAQDLAGMKERMAQFAQSYIDKRGGLEPETQSNILSTSLSVMADTNEHNNEILHSSEENATNQPVNENNDLK
What is the function of this protein?
High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:8901598, PubMed:9564039).  The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2 (PubMed:9564039).  Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation.  Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity).  SNF3 is involved as well in the transport of mannose and fructose (PubMed:20014043).  Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039).
What are the official names of this protein?
Low glucose sensor SNF3, High-affinity glucose receptor SNF3, High-affinity transporter-like sensor SNF3, Sucrose nonfermenting protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHAS_CAMJE
Sequence: MSKKQKIAIVGATGAVGEELLNVLDELDFPVESILPLASAKSVGSEVEFKGKAYKVKELTENVFKENPIDIAFFSAGGSVSEKYAKFAVESGAVVIDNTSHFRMEKDVPLVVPECNPEDIKDWKKTGIIANPNCSTIQMVQVLKPLNDAFNLKRVDVSTYQAASGAGKEGMQELVEAMQSFFAFKLDEFEPQTFPYTLALNLIPQIDVFMDNDYTKEELKMVNETQKILHKNLEVSATCVRVPVLRSHSEAITMHFEKEIDVKKAKEILKKAPSVIVIDDPKNKKYPMPLMTSDTNETYVGRIRADVYDKKILHLWCVADQIRVGAATNAVRIAQKWLELKNK
What is the function of this protein?
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
What are the official names of this protein?
Aspartate-semialdehyde dehydrogenase, ASA dehydrogenase, ASADH, Aspartate-beta-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: PSYI_PSEAJ
Sequence: MSSGFEFQLASYTTMPVTLLETLYSMRKKIFSDRLEWKVRVSHAFEFDEYDNAATTYLVGSWNGVPLAGLRLINTCDPYMLEGPFRSFFDCPAPKNAAMAESSRFFVDTARARSLGILHAPLTEMLLFSMHNHAALSGLQSIITVVSKAMARIVRKSGWEHHVLSTGEASPGETVLLLEMPVTADNHQRLLGNIALRQPVTDDLLRWPIALGVSGSAPQACMHSAA
What is the function of this protein?
Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), an autoinducer molecule.
What are the official names of this protein?
Acyl-homoserine-lactone synthase, Autoinducer synthesis protein PsyI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: DNAT_SALEP
Sequence: MSSRILTSDVIGIDALLHDHHAVLAKSTGGAVAVFANNAPAFYAVTPARMAELLALEEKLSRPGSDVALDAQFYEEPEAAPVAIPCGKFAMYPAWQPDADFQRQAALWGVALREPVTAEELAAFIAYWQAEGKVFHHIQWQQKLARSVQISRSSNGGMPQRDINSVSEPDNHIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: MNMA_AERS4
Sequence: MTDNSQIKVIVGMSGGVDSSVSAYLLQQQGYQVEGLFMKNWEEDDTDEYCSASQDLADAKAVCDKLGMKLHTINFAAEYWDNVFEHFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEELGATYIATGHYVRRDDSTGHPRLLRGLDSNKDQSYFLYTLSEKQVGQSLFPVGDLEKPEVRRIAEQLDLITAKKKDSTGICFIGERKFKDFLAKFLPAQPGPIETVDGKVIGEHQGLMYHTLGQRKGLGIGGRKDATEEAWYVVDKEVERNTLVVAQGEHPRLYSDGLIASQLHWVDRTPIRAPRRCTVKTRYRQQDIPCLIQPIDDETIRVIFDEKQAAVTPGQSAVFYDGEVCLGGGIIEQRFSHPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SULF1_MOUSE
Sequence: MKYSLWALLLAVLGTQLLGSLCSTVRSQRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEQGGATFTNAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPIMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQRKRLQTLMSVDDSVERLYNMLVESGELDNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEPGSIVPQIVLNIDLAPTILDIAGLDSPSDVDGKSVLKLLDLEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESGKNIQQSNHLPKYERVKELCQQARYQTACEQPGQNWQCIEDTSGKLRIHKCKGPSDLLTVRQNARNLYSRGLHDKDKECHCRDSGYRSSRSQRKNQRQFLRNKGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEELQVLPPRSIAKRHDEGHQGFIGHQAAAGDIRNEMLADSNNAVGLPATVRVTHKCFILPNDTIHCERELYQSARAWKDHKAYIDKEIEVLQDKIKNLREVRGHLKKRKPEECGCGDQSYYNKEKGVKRQEKLKSHLHPFKEAAAQEVDSKLQLFKEHRRRKKERKEKKRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERSILNQLHIQLMELRSCQGYKQCNPRPKSLDIGAKEGGNYDPHRGQLWDGWEG
What is the function of this protein?
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity).  It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity).  Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity).
What are the official names of this protein?
Extracellular sulfatase Sulf-1, mSulf-1, Arylsulfatase, N-acetylglucosamine-6-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface.
Protein: MURJ_BUCAP
Sequence: MNILKSLISVGIMTLISRIFGFFRDVLIAHIFGASMFTDAFFIAFKIPNLLRRIFAEGAFYQSFIPILIDYKSRKDKEYIQEFIRSTCGFTILVLTTFVILGIIFSDYIIFISAPGFSESSKKLQLASNLLKIMFPYILFISLSSLCSSILNSYNYFFIPSLSSSLLNISIIVFSFFFSDYFEPSIISLAWSVMIGGFFQLFYQFPHLYKIKMLVFPKINFKNIGLIKVLKKMGPSTLGSCANQISLIFNTIFSSLLHSGSISWIYYADRLIEFPIGIIGVSLSTILFTSFSCSYSNNTQSEYKILLNWGIRFGLILSLPISVILFMFSKPLVIILFQYGKFTDFDVLMTQKALELYSFGLVSFILVKILVSAFYSCQEVNIPMRISILTLFLTQLMNPFLIFYFQHSGLALSCSIASWINFFLLYWKLYQKGIINFKLNDFIFIFRLLIAVLVMTFFLIFMLYFIPSWKIGSFFDKIIRLFTILSISGIVYLIALHFLGIRLLNYSDKLFQKK
What is the function of this protein?
Involved in peptidoglycan biosynthesis.  Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
What are the official names of this protein?
Probable lipid II flippase MurJ.
What is the protein family that this protein belongs to?
Belongs to the MurJ/MviN family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WRK54_ARATH
Sequence: MDSNSNNTKSIKRKVVDQLVEGYEFATQLQLLLSHQHSNQYHIDETRLVSGSGSVSGGPDPVDELMSKILGSFHKTISVLDSFDPVAVSVPIAVEGSWNASCGDDSATPVSCNGGDSGESKKKRLGVGKGKRGCYTRKTRSHTRIVEAKSSEDRYAWRKYGQKEILNTTFPRSYFRCTHKPTQGCKATKQVQKQDQDSEMFQITYIGYHTCTANDQTHAKTEPFDQEIIMDSEKTLAASTAQNHVNAMVQEQENNTSSVTAIDAGMVKEEQNNNGDQSKDYYEGSSTGEDLSLVWQETMMFDDHQNHYYCGETSTTSHQFGFIDNDDQFSSFFDSYCADYERTSAM
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).  Together with WRKY70, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes (PubMed:22268143).  Positive regulator of EDS1-dependent defense against E. amylovora (PubMed:22316300).  In collaboration with WRKY70, prevents stomatal closure and, consequently, osmotic stress tolerance (PubMed:23815736).  Together with WRKY46 and WRKY70, promotes brassinosteroid (BR)-regulated plant growth but prevent drought response by modulating gene expression (PubMed:28576847).  Negative regulator of SA biosynthesis (PubMed:28837631).  Prevents defense response to the necrotrophic pathogens P. carotovorum and B. cinerea, but promotes defense against biotrophic/hemibiotrophic pathogens P. syringae pv.  tomato (Pst) DC3000, probably by regulating negatively the jasmonic acid (JA)/ethylene (ET) and positively the salicylic acid (SA) signaling pathways (PubMed:28837631).
What are the official names of this protein?
Probable WRKY transcription factor 54, WRKY DNA-binding protein 54.
What is the protein family that this protein belongs to?
Belongs to the WRKY group III family.
What are the subcellular locations of this protein?
Nucleus.