PharMolix/UniProtQA huggingface dataset:
Protein: MIAA_METFK
Sequence: MLISQPPAIFLMGPTASGKTGLAVELVQAMPLEIISVDSALVYQDMDIGTAKPGQEVLQRAPHHLIDVIDPMQVYSAAQFREDALRLMADITARGKAPLLVGGTMLYFRTLEQGLGGLPEADAQVRAELDREAAKIGWPGMHAKLAAIDPETAARLQPADSQRIQRALEVYRLTGKSMTALHRQQAAEILPYRLLKIALQPSDRSVLHARIAERFVAMMKGGLLEEVQGLLKKYPGLHPDMTSMRCVGYRQTLEYLAGNIDDEAWKAQGIAATRQLAKRQLTWLRGMDDTLVLDCLEQDVYGQAQRAISGFLSAV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GPD1_ZYGRO
Sequence: MAATDRLNQTSDILSQSMKKTDSSMSVVTAENPYKVSVVGSGNWGTTIAKVVAENTKEKPELFQERVDMWVFEEQIDGTPLAQIINTKHQNVKYLPNIDLPDNLVANPDLIATTKDADVIVFNVPHQFLGRIVAQMKGQIKPTARAVSCLKGFEVGPKGVQLLSDYVTQELGIECGALSGANLAPEVAKEHWSETTVAYHIPDDFKGDGKDIDHRVLKQLFHRPYFHVNVIDDVAGISIAGALKNVVALGCGFVTGLGWGNNAAAAIQRVGLGEIIKFGRMFFPESKVETYYQESAGVADLITTCSGGRNVRVATEMAKTGKSGEQVEKDILNGQSAQGLVTCKEVHQWLESSGNTEDFPLFEAVYQITYENVPMKELPSMIEELDIDSTSKCVLSYKMGL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1, ZrGPD1.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_YERPN
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAEAIVYTALETLAQRSGKDFLEAFEVALDNVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVDAARKRGDKSMALRLANELSDAAENKGSAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MYC1_CRODU
Sequence: MKILYLLFAFLFLAFLSEPGNAYKQCHKKGGHCFPKEKICIPPSSDFGKMDCRWRWKCCKKGSGK
What is the function of this protein?
Cationic peptide that possesses multiple functions.  It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.  It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism.
What are the official names of this protein?
Crotamine CRO1.
What is the protein family that this protein belongs to?
Belongs to the crotamine-myotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPRTL_STAAR
Sequence: MNNEILQRMVENLSEEKFGRTFQHRAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKGYQHKDQDFKRLSQQVGAPRFCNSIESYQQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBPB_MORCA
Sequence: MKHIPLTTLCVAISAVLLTACGGSGGSNPPAPTPIPNASGSGNTGNTGNAGGTDNTANAGNTGGASSGTGSANTPEPKYQDVPTDKNEKEQVSPIQEPAMGYGMALSKINLHNRQDTPLDEKNIITLDGKKQVAEGKKSPLPFSLDVENKLLDGYIAKMDKADKNAIRRRIESENKAKPLSEAELAEKIKEAVRKSYEFQQVMTSLENKIFHSNDGTTKATTRDLQYVDYGYYLANDANYLTVKTDKPKLWNSGPVGGVFYNGSTTAKELPTQDAVKYKGHWDFMTDVANKGNRFSEVKGTRQAGWWYGASSKDEYNRLLTDEKNKPDGYNGEYGHSSEFTVNFKEKKLTGGLFSNLQDSHKQKVTKTKRYDIDANIHGNRFRGSAIASDKEKDSETKHPFTSDAKDRLEGGFYGPKGEELAGKFLTDDNKLFGVFGAKQESKADKTEAILDAYALGAFNKNDANTFTPFTKKQLDNFGNAKKLVLGSTVINLVSTDATKNEFTEDKPKSATNKAGETLMVNDKVSVKTYGYGRNFEYLKFGELSVGGSHSVFLQGERTATTGDKAVPTEGKAKYLGNWVGYITGTGTGKSFNEAQDIADFDIDFKNKTVNGKLTTKGRTDPVFNITGEISGNGWTGKASTAKADAGGYNIDSNGTNKSIVIRDADVTGGFYGPNATEMGGSFTHNTNDSKASVVFGTKRQEEVKP
What is the function of this protein?
Moraxella acquires iron by extracting it from serum transferrin (TF) in its human host.  Acts as a transferrin receptor and is required for transferrin utilization.
What are the official names of this protein?
Transferrin-binding protein B, TbpB.
What is the protein family that this protein belongs to?
Belongs to the TbpB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Cell surface. Note=When expressed in E.coli.
Protein: CARB_YEAST
Sequence: MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLAIGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKVPQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLRELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKIAEKIKILESHDVIVPPEVRSWDEFIGFKAY
What are the official names of this protein?
Carbamoyl-phosphate synthase arginine-specific large chain, Arginine-specific carbamoyl-phosphate synthetase, ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_CAMLR
Sequence: MEVTAKLIDFANANATVKIAQGAIKAEVEKLAKKASKTMKMDGFRAGKVPVAAILKRYEKELTRDAEQDLLRNAVDGALKEVKKDAKDLVGEPYFEKFDRKDGAIEAQMVLSFRPEVKLDGYEELVPTYNTPKVTQKEIDAKKEELLKRFATPEAIKEDRALKEGDFAKFDFEGFVDGKAFDGGKAQNYVLEIGSKQFIPGFEEGMIGLKIGEEKDINVTFPKEYGATHLAGKDAVFKVKLHEIQELKLPELNEELLKSLLPEEKEPSVEKLEAKLKEQLKNEKIFKLINDELKNQFAEALVAKFDFVLPKNIVEQETDMQFRSSLRNLSEEELKEFKDEAKYKEKRESFKEDAQKSVKLTFIIDELAKLRNVTVSDQELIQAIYFEAYRYGFNPQEHLDNYKKQGALPAIKMSLIEEKLFADIFKKNDKKKTEKESEK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: H1_WHEAT
Sequence: MSTDVAAADIPVPQVEVAADAAVDTPAAKPAKAPKAAKAKKSTPGPKKPRVTPAHPSYAEMVSEAIAALKERSGSSTIAIGKFIEDKHKAHLPANFRKILLTQIKKLVAAGKLTKVKGSYKLAKAPAAVKPKTATKKKPAAKPKAKAPAKKTAAKSPAKKAAAKPKAKAPAKAKAVAKPKAAAKPKAAAKPKAKAAAKKAPAAATPKKPAARKPPTKRATPVKKAAPAKKPAAKKAKK
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HFLD_ECOHS
Sequence: MAKNYYDITLALAGICQSARLVQQLAHQGHCDADALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL
What is the function of this protein?
Negative regulator of phage lambda lysogenization.  Contributes to the degradation of the phage regulatory protein CII.  Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease.
What are the official names of this protein?
High frequency lysogenization protein HflD.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTB_SALSA
Sequence: MDPCECSKTGSCNCGGSCKCANCACTSCKKSCCPCCPSGCSKCASGCVCKGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: SEPS_METVS
Sequence: MFKREEIIEMANKDFEKAWIETKGLIKSKRVNESYPRIKPIFGKTHPVNDTIENLRQAYLRMGFEEYINPVIVDERDIYKQFGPEAMAVLDRCFYLAGLPRPDVGLSDEKISQIEKLGINVSCHKESLQKILHGYKKGTLDGDDLVLEISKALEISSEMGLKILEEVFPEFKDLIAVSSKLTLRSHMTSGWFITLSELNGKKPLPFKLFSIDRCFRREQKEDKSHLMTYHSASCVIAGKDVDINDGKAVAEGLLSQFGFTNFKFIPDEKKSKYYTPETQTEVYAYHPKLKEWLEVATFGVYSPVALSKYGIDVPVMNLGLGVERLSMISGNFEDVREMVYPQFYEQSLSDRAISSMVKFDKVPVLDEIYDLTKELIDLCVKNKDITSPCNLKLEKTFIFGKTKKNVKIIVFEKEENKKLLGPSILNEIYVYDGNIIGIPETFEGVKEEFKEFLEKGKVEGVTTGIRYIDALCFKITSKVEEAFVSNTSEFKLKVPIVRSLSDINLKIEEIALKQIMSKNKVIDVRGPVFLNVEVKIE
What is the function of this protein?
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
What are the official names of this protein?
O-phosphoserine--tRNA(Cys) ligase, O-phosphoserine--tRNA ligase, Non-canonical O-phosphoseryl-tRNA(Cys) synthetase, O-phosphoseryl-tRNA(Cys) synthetase, SepRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
Protein: RNPA_MICAN
Sequence: MGLPQIHRLKHRQDFQAVYGTGKRYHGSHLTLISLEDSCPDAPGPSRFGISISKKVSKKAVVRNRLKRQIRAVIRELLPEIAAGWRGIIIIRPGAIECNYEHFLRELKQLLVKANIIHGH
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: GLE1_SCHPO
Sequence: MDTKTTPLIHAKLDEKIISSYNDANGLDIDDLWDIYNEKTRRMIHIISQRYKPKKQSPFPVIADENVRIFPPLHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKETFKDDPEEDSNMAWSIIHKIKTEVVAPISEKKELKNYCFTQKRKITPRLGQITKSNSQIMKITQLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNPISAYPLAKVCLLLQTQNADLKDLLFARLQKNCPWVIPFWYDHGTENGKKKMGFKKLSDGHWEQNTTYNERQCGIFAVYAAILSLDDSLAPESWRTFSRLLNLPSPSQLMKSDLELGQTLCSIVSTYLDIAGQSLLRIYGRQAKKLIVCSFSEAYLGANGGGSQYGRLRIVGEDWMKGQGGLKFSFEP
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC (By similarity).
What are the official names of this protein?
mRNA export factor gle1, Nuclear pore protein gle1, Nucleoporin gle1, RNA export factor gle1.
What is the protein family that this protein belongs to?
Belongs to the GLE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.
Protein: UBIE_FRAP2
Sequence: MSKENKTTDFGFTEVPWEEKQKKVAGVFHSVAAKYDLMNDLMSFGIHRIWKKQTIAKTGVRKGDKVLDLAGGTGDLAYKFCQMVGSQGKVVLSDINSSMLEVGKEKLTNKGCVGNIEYVQANAECLPFPDNYFDCITISFGLRNVTDKAKALASMCRVLKPGGRLLVLEFSKPIVPMLSKVYDEYSFKALPFLGKIITQDAESYKYLAESIRKHPDQETLKQMMYDAGFDNVEYQNMTGGIVALHIGYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: TRMA_NEIMF
Sequence: MSDYTQQLQDKKDHLKTLFAGLDVPEWEVYESPDKHYRMRAEFRIWHEGGEMFYAMFEKGQKAGGASLIRCDRFEAASEAVNRLMPELIAVAAQSAELRNRWYAVEFLSTLSGEMLVTMIYHKRLDNEWMQAAQALQQQLDISVIGRSRGQKIVLKQDYVTETLKVGNRDFRYRQIEGSFTQPNAAVCQKMLEWACGAAEGLDGDLLELYCGNGNFTLPLSEKFERVLATEISKTSVSAAQWNIEANRIGNIKIARLSAEEFTEAYTGKREFKRLKDGGIALTDYAFSTIFVDPPRAGIDEETLKLVSQFDNIIYISCNPETLRTNLDTLAETHTVERAALFDQFPFTHHIESGVLLKKKILGKSKR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: IOLB_GEOTN
Sequence: MSRFIISSHSPNEEGNVVRVTPESAGWEYVGFEVYALTKGQTLRKETIDQEACLVLLKGKANIHTRHERWENIGLRMDVFEKIPPYSVYVPSNDVYEVQALTDLELAVCLAPGKGTYPARLIPPSEVGVEMRGAGNIERRIHNILPESKPADSLLVVEVFTPEGNWSSYPPHKHDQHNLPHESYLEETYYHQINPDHGFMVQRVYTDDRSIDETMVVKNGDVVLVPKGYHPVSAPPGYEGYYLNVMAGPVRTWKFRNDPDHEWVMESKLAAKQK
What is the function of this protein?
Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
What are the official names of this protein?
5-deoxy-glucuronate isomerase, 5DG isomerase.
What is the protein family that this protein belongs to?
Belongs to the isomerase IolB family.
Protein: YQAC_BACSU
Sequence: MKKNIHILGASGVGTSTLGAALSKRLPHTHLDTDNYYWLDKFTKKREIPERRKLLEKDLTINEKWILSGAVCGWGDNLKSYFDLVVFLWIPQDIRLERLRHREFQRYGNEVLAGGSKYEQSKTFLEWASLYDNAGMEVRSRALHEHWMADLSCPVLKIEDDCSVNERVDRVLDYLSSN
What are the official names of this protein?
Uncharacterized protein YqaC.
Protein: GPDA_ANAMM
Sequence: MQVTILGAGAFGTALSIALCNTGKKVRIWSRNGQVVESLRTHGENSVYLPGFKVPREVLVHSDMGLATDGPAAILMCVPAQELRSLCNTITAASALEAGVPLLVCSKGIENSSLKFPSEVVAEMFPQNPVFVLSGPALARELASGLPCAMVLAGDEITTAETLASQLSGPALAIVHSGDLMGVQVGAVMKNIIAIASGIIAGMGLGHNASAIVMVQGMSEIKAVCEAKVGVAATETLIGLSCLGDLVLTCTAPGSRNMSFGSSVGKAGRAGASGQQKPMLVEGVESVTAMVNMGKALNLELPICSAIARMLHGQLGVRQAAAEILSAPVKSRLNV
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCID2_DROME
Sequence: MFGTVNNYLSGVLHAAQDLDGESLATYLSLRDVHVQNHNLYIAQPEKLVDRFLKPPLDEVVSAHLKVLYHLAQEPPGYMEAYTQQSAACGAVVRLLQQLKDENWCLPLMYRVCLDLRYLAQACEKHCQGFTPGHVLEKAADCIMACFRVCAADGRASEEDTKRLGMMNLVNQLFKIYFRINKLHLCKPLIRAIDNCIFKDSFPLPEQITYKYFVGRRAMFDSNYQAAVQYLSYAFSNCPDRFASNKRLILIYLVPVKMLLGYLPSKSLLQRYDLLLFLDLAMAMKAGNVNRFDEIVRDQELVLIRSGIYLLVEKLKFLVYRNLFKKVFVIRKSHQLDMGDFLSALHFVGLTDVSLDETHCIVANLIYDGKIKGYISHAHNKLVVSKQNPFPSVSL
What is the function of this protein?
Required for the export of nuclear mRNAs and involved in mRNA trafficking in the cytoplasm (PubMed:27016737, PubMed:28554770, PubMed:33602059).  Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:27016737, PubMed:28554770, PubMed:33602059).  Within the complex, specifically promotes the association of factors involved in regulating nuclear mRNA export, such as Moe, sbr/NXF1 and the ORC complex, to the mRNPs particles (PubMed:27016737, PubMed:28554770, PubMed:33602059).  In the cytoplasm, functions independently of its role in the TREX-2/AMEX complex, to promote cytoplasmic mRNA trafficking together with nudC (PubMed:33602059).  Associates with translationally active polysomes (PubMed:18086857).
What are the official names of this protein?
PCI domain-containing protein 2 homolog, CSN12-like protein.
What is the protein family that this protein belongs to?
Belongs to the CSN12 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus membrane. Cytoplasm, cytoskeleton. Note=Shuttles in and out of the nucleus by a emb/Crm1-dependent mechanism (PubMed:18086857). The ubiquitinated forms are localized to the cytoplasm, the nonubiquitinated forms are localized to the nucleus, and both forms are associated with the nuclear membrane (PubMed:33602059). Associated with cytoplasmic microtubules (PubMed:33602059). Associates with mRNA in the nucleus and cytoplasm (PubMed:33602059).
Protein: MER_METJA
Sequence: MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGPGVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEVIRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQGPKMLETAGMIADGVLINASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPPVVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMGVTQIVAGSPIGPNKETAIKLIGKKVIPALKE
What is the function of this protein?
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
What are the official names of this protein?
5,10-methylenetetrahydromethanopterin reductase, Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase, Methylene-H(4)MPT reductase.
What is the protein family that this protein belongs to?
Belongs to the mer family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_FUSNN
Sequence: MVLGGLMKLFDEFKAFVMRGNVVDLAVGVIIGAAFGKIVTSLVNDIFMPIIGMIIGNIDFSSLVIKLGEPVEGAEQAAIRYGMFIQEIVNFLIIALCVFVAIKLINKLQKKKEEASAPAPGPTKEEVLLTEIRDALNKIAEK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUA_FRATO
Sequence: MKNYLLQIEYFGKNYCGWQRQSHSLSVQEELEKALSKIANQNIEVTCAGRTDTGVHATSQIVNFYSNAYRPLSAWQRGVNALLPQDIKILAVQQVDNNFNSRFTAINRTYNYIIYNSATSSPIFAEHCLWENRELDIDKMNQACEYLLGEQDFSSFRSSQCQSNTPFRNIQKAEFIKQGSFIVFEVVGNAFLHHMIRNLVGSLLKVGLGFESPEWIKVVLEAKDRTQAAETAKAHGLYFVGVEYPEFSFKRQIIKLFC
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: INSV_DROME
Sequence: MENQYQRIVSATAREDSQARRSKPLFLNAWSQTSSVDFEVLRSISAPDPQVEVENRALRDKVRYLEAKLQQHKDLLSQIHATSARMQQASSLLAESRPPTPPAVQSHHILTPPSSEICAPAQNPQILDYKIISAPDDADAIEIRLAAESLNSLSTSADSDRLEICLGDENHQQSNHHNSQQQYRISNGIKRDGSSESADTPLQFIKRRKLQEIQLQEEIPRQNIKLPAKPQVKARNGSFTDLNKGQQQNMDNVMVSIGPNNTCVPASVFENINWSVCSLATRKLLVTIFDRETLATHSMTGKPSPAFKDQDKPLKRMLDPGKIQDIIFAVTHKCNASEKEVRNAITTKCADENKMMKIQNVKRRSSGIKHEKENII
What is the function of this protein?
Can act as both a transcriptional repressor and corepressor.  Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495, PubMed:23468431).  Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development (PubMed:21765394, PubMed:25561495).
What are the official names of this protein?
Protein insensitive.
What are the subcellular locations of this protein?
Nucleus.
Protein: IXO39_IXOSC
Sequence: MNAALIAALLILGALTLDATAYSSTCERIPCTNNSDCHGPDLCQCRPPRGDDFGYFCSEY
What is the function of this protein?
Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks (Probable).  Inhibits platelet aggregation induced by ADP, thrombin and thromboxane A2 (TXA2) (PubMed:25152502).  Blocks platelet adhesion to soluble collagen (most probably through the binding to alpha-2/beta-1 integrin (ITGA2/ITGB1)) and binds to purified glycoprotein IIb/IIIa (ITGA2B/ITGB3) in a dose-dependent manner (PubMed:25152502).  In vivo, reduces thrombus weight effectively in a rat arteriovenous shunt model and inhibits thrombosis in a carrageenan-induced mouse tail thrombosis model (PubMed:25152502).
What are the official names of this protein?
Ixodegrin YY-39, Platelet aggregation inhibitor, PAI, Tick anti-thrombosis peptide.
What is the protein family that this protein belongs to?
Belongs to the ixodegrin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CIP2A_MOUSE
Sequence: MDSTACLKSLLLSISQYKAVKSEANATQLLRHLEVVSGQKLTRLFTSHQILPSECLSCLVELLEDPNISASLILSIISLLSQLAIDNETRDCLQNIYNLNSVLSGVVCRSSACHNDSVFLQCIQLLQRLTYNAKFFHSGAHIDDLITFLIGHVQSSEDELTMPCLGLLANLCRHNLSVQTQIKTLSNVKSFYRTLISFLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLSQVLGLLNAKDPDSSSKVLELLLAFCAVTQLRHVLSQMMFEQSPSGNILGSRPKSLEPTAALLRWLSQPLDGAENCSVLALELFKEIFEDVIDTGNCSSTDHFVTLLLPTILDQLQFKEQNLDETLVRNKCERMVKAIEVLLTLCGDDSLKMHVVKILTTLKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVILKTLTLMNKLKQLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLGILLEASPLPDFPAFVLGESIAANNVYRQQETEHLPRKMTFQPLNHGFSTSAKCLTPPPSKDNAPALNIEDLIEKLQAGVMVKDQISDIRISDIMDVYEMKLSTLASKESRLQDLLEAKALALAQADRLIAQYRCQRTQAETEARTLAGMLREVERKNEELSVLLKSQQLESERAQNDIEHLFQHSKKLESVAAEHEILTKSYMELVQRNEATEKKNTDLQTTCESLNKHIETMKKLNEALKQQNEKTIAQLIEKEEQRKEVQSQLADRECKLSNLHKIAKSQEEKLNVLQKEKEDKQETIDILRKELSRTEQIRKELSIKASSLEMHKAQLEGRLEEKESLLKLQQEELNKHSHMIAMIHSLSGGKISPETVNLSI
What is the function of this protein?
Promotes anchorage-independent cell growth and tumor formation.
What are the official names of this protein?
Protein CIP2A, Cancerous inhibitor of PP2A, p90 autoantigen homolog.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm. Note=Slightly concentrates in the perinuclear region.
Protein: SYC_RHOPT
Sequence: MELRLYDTLTRDKRPFTPIDPANVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHLYGEAHVKYVRNITDVDDKINDRAARDYPGLPLNEAIRKVTEQTERQFHDDVDALGCLRPTVEPRATEHIGEMRSIIEKLVAGGFAYVEQDHVLFSPSAMNAANGVLPRYGSLANRSLDEMIAGARVDVAPYKRDATDFVLWKPSKPGEPSWPSPAGIATPGRPGWHIECSAMSWKHLGETFDIHGGGIDLVFPHHENEVAQSCCAFHTKRMAQTWMHNGFLQVEGEKMSKSLGNFITIRELLATNKFGGRSWDGATLRLAMLKTHYRQPIDWTVDALEEAQKRVAKYRRTLERFRGGKNVEVPHGVVSALSDDLNTHAAITELDALNRRANGVTHEGPTSEADALAANAIAADELRASLRLLGISVASERSGAVNQIFDQNIQRLIAVRTAARANKDWKESDRIRDELAAMGVVLKDGKDADGKPVTTWELAR
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.