PharMolix/UniProtQA huggingface dataset:
Protein: DMAC2_BOVIN
Sequence: MAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA
What is the function of this protein?
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).  Involved in the assembly of the distal region of complex I.
What are the official names of this protein?
Distal membrane-arm assembly complex protein 2, ATP synthase subunit s-like protein.
What is the protein family that this protein belongs to?
Belongs to the ATP synthase subunit s family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NDUF6_MOUSE
Sequence: MATSMLGSVRGPRPFGLANLFHRQPPRDAWERVRRLPGPSAVRRSVAAASGPGIPGSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWKKAVEDMYCDNPPHQPVAIELWKAVKKHNLTKRWLMRIIDEREKNLDDKAYRSMQELENYAENTQGSLLYLTLEVLGVKDLHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHRSVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNMLLPLSLYIQSWRKRY
What is the function of this protein?
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages.  May play a role in the biogenesis of complex I subunit MT-ND1.
What are the official names of this protein?
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.
Protein: MDCC_PSEPW
Sequence: METLTFQFPAAEPGRGRTLVGCVSSGDLEVLMEPGTAGSLNIQVVTSVNGSGARWEQLFQRLFQGRTWPAVNIDIHDFGATPGVVRLRLEQGFEEIAHD
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2546_HUMAN
Sequence: MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI
What is the function of this protein?
Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27543974, PubMed:27390132).  May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132).  Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132).
What are the official names of this protein?
Mitochondrial outer membrane protein SLC25A46, Solute carrier family 25 member 46.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: RPOB_SALPC
Sequence: MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVVFEIRDNKLQMELIPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDIKHIEVPVEYIAGKVVSKDYVDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETVRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLRDEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRRVVDGVVTDEIHYLSAIEEGNYVIAQANSNLDDEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGTVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVSGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDDEVLRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQITLFDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: YIK2_YEAST
Sequence: MLKVEKFKKLKRFEVYYCLKNSFLEEVDIEMKYSCSITTIMSNGSASLLMNWEELTPGHCFTSYTTNPIAGDYGLNASAIDGHTEELVATHPAGTLENATQ
What are the official names of this protein?
Uncharacterized protein YIL102C.
Protein: TSAD_RALPJ
Sequence: MLVLGIESSCDETGVALYDTHSGLRAHALYSQIAMHREYGGVVPELASRDHIRRVIPLLEEVLGKAGATRADIDAIAYTKGPGLAGALLVGASVANALAFALGKPLVAVHHLEGHLLSPLLEADRPEFPFLALLVSGGHTQLMRVDAVGQYTLLGETLDDAAGEAFDKTAKLLGLGYPGGPAVSRLAEFGNPGVFDLPRPMLHSGNFDFSFAGLKTAVLTQVRKLNLTDSETCYQPRADLARAFVDAIVEVLVKKTLRAAREHGLKRIVVAGGVGANRQLREGLNAEGKKRGLRVYYPDLQFCTDNGAMIAFAGAMRLQADPAQVQDGYGYGVTPRWDLEDIRIRHA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLAT_HUMAN
Sequence: MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMAAKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEKATRPSQGHQP
What is the function of this protein?
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
What are the official names of this protein?
Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
Protein: SUCC_BORA1
Sequence: MKIHEYQGKELLKQFGVPVPRGIPAFSVEEAVAAAEKLGGPVWVVKAQIHAGGRGKGGGVKLARSLDEVRQLASQILGMQLVTHQTGAQGQKVNRLYIEDGADIQKEYYVSLVTDRGTQKVALIASSEGGMDIEEVAHSTPEKIITEYIDPIVGLTDAQAKKVADAIGMPADSTAQAVDVFKKLYQCYMDTDASLVEINPLNRDSKGNIIALDAKFNFDSNALFRHPEIVAYRDLDEEDPAEIEASKFDLAYIQLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATAEKVTEAFKIMLKNKGVKAILVNIFGGIMRCDVIAEGVISACKAVNLSVPLVVRMKGTNEELGKKMLAESGLPIISADTMAEAATKVVAAAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RK33_ORYSJ
Sequence: MAKGKDVRIRVILQCVSCVRKGANEESAGISRYSTQKNRHNTPGQLELRKFCRYCRKHTIHAEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AVR2B_HUMAN
Sequence: MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
What is the function of this protein?
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c).  Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.  Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA).  The type-1 receptors like ACVR1B act as downstream transducers of activin signals.  Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase.  The activated receptor type-2 then phosphorylates and activates the type-1 receptor.  Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.  Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4.  This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.  Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
What are the official names of this protein?
Activin receptor type-2B, Activin receptor type IIB, ACTR-IIB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: LSPA_ECOHS
Sequence: MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGISVILAVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKAKKQ
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACMSD_RAT
Sequence: MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMMKDGKVFRVIQQNCWDPEVRIREMNQKGVTVQALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPGLAVEEMERCVKELGFPGIQIGSHINMWDLNDPELFPIYTAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTTAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCARDNSSDPRKYLGSFYTDSLVHDPLSLKLLTDVIGKDRVILGTDYPFPLGEQEPGKLIESMADFDEETKDKLTAGNALTFLGLERKLFE
What is the function of this protein?
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).  ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders.  In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite.  ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
What are the official names of this protein?
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Picolinate carboxylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
Protein: RL13_ACTP7
Sequence: MKTFVAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVINAEKVAVTGKKETDKIYYWHTGYVGGIKDATFKEMIARRPEAVIEIAVKGMLPKGPLGREMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: KGUA_FRATH
Sequence: MNNYIFIISAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVAEFEQLLSQDGFIEYAKVFKNYYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAKSIFILPPSLDELRKRLEKRNTDSKETIDYRMEQVQSEISHADEYDYLLVNDDFSQSLEQLCKYFEQNIQS
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNS_SCHPO
Sequence: MCGILAVHHVAEDIEAFKPKALHLSKQLRHRGPDWSGKAIRNQTILCHERLAIVGVESGAQPLVSDDGKLVLTVNGEIYNHLKLRENLKGNYKFKTYSDCEVILYLYREHGPACANMLDGMFSWVLYDQDKDKVVAARDPIGITTLYQGFSSDSPDTAYFASELKALHPVCDKIIAFPPGHYYDSETKQTVRYFKPSWWDENKIPSNPVDYKLLRETLEASVRKRLMAEVPYGVLLSGGLDSSLIASIAARETEKLANSTSQSEEARTITAWPKLHSFAIGLPGSPDLLAARKVADFLHTFHHEHTFTIDEGLDALRDVIYHLETYDVTTIRASTPMYLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFGNAPSREAFHSECVRRVKNLHLSDCLRANKSTMAWGLEARVPFLDKDFLEVALNIDPEEKMYINGRKEKYILRKAFDTTHDSSLQPYLPQDILWRQKEQFSDGVGYSWIDALKDTAELCISDDEFALPRREWGDDIPTTKEAFWYRKLFDEIFPRQCADTVMRWVPKAEWGCPEDPSGRYQAGHVAALK
What are the official names of this protein?
Probable asparagine synthetase [glutamine-hydrolyzing], Glutamine-dependent asparagine synthetase.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DFRA_ANTMA
Sequence: MSPTSLNTSSETAPPSSTTVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPGNMKKVKHLIELPKADTNLTLWKADMTVEGSFDEAIQGCEGVFHLATSMEFDSVDPENEVIKPTIDGMLNIIKSCVQAKTVKKFIFTTSGGTVNVEEHQKPVYDETDSSDMDFINSKKMTGWMYFVSKILAEKAGMEAAKENNIDFISIIPPLVVGPFIMPTFPPSLITALSPITGNEAHYSIIKQCQYVHLDDLCEGHIFLFEYPKAEGRYICSSHDATIYDIAKLITENWPEYHIPDEFEGIDKDIPVVSFSSKKMIGMGFIFKYTLEDMVRGAIDTCREKGMLPYSTKNNKGDEKEPILNSLENNYNIQDKELFPISEEKHINGQENALLSNTQDKELLPTSEEKRVNGLESALLSKIQDKEVLPTSGVKHAKGQENALLPDIANDHTDGRI
What is the function of this protein?
Bifunctional enzyme involved in flavonoid metabolism.
What are the official names of this protein?
Dihydroflavonol 4-reductase, DFR, Dihydrokaempferol 4-reductase, Flavanone 4-reductase, FNR.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: CYC5_PSEME
Sequence: AASAGGGARSADDIIAKHCNACHGAGVLGAPKIGDTAAWKERADHQGGLDGILAKAISGINAMPPKGTCADCSDDELREAIQKMSGL
What is the function of this protein?
It is unreactive with cytochrome c reductase or oxidase but seems to function as an intermediate in nitrate respiration of facultative anaerobic pseudmonads.
What are the official names of this protein?
Cytochrome c5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
Protein: MED21_YEAST
Sequence: MTDRLTQLQICLDQMTEQFCATLNYIDKNHGFERLTVNEPQMSDKHATVVPPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQLRKIDMLQKKLVEVEDEKIEAIKKKEKLLRHVDSLIEDFVDGIANSKKST
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II.  The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21, RNAPII complex component SRB7, Suppressor of RNA polymerase B 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYI_GLAP5
Sequence: MTDYKNTLNLPETGFPMRGDLAKREPAMLQNWHDKKLYQKIREASKGKRSFILHDGPPYANGNIHLGHAVNHILKDIINKSKTAMGFDTPYVPGWDCHGLPIELKVEGLVGKPNENISASEFRQKCREYAKEQVDGQKADFMRLGILGDWDNPYLTMNFDTEAHIIRTLGKVIANGHLYKGSKPVHWCLDCGSSLAEAEVEYEDKVSPSIYVRFSAVDPVAVEAKFNAQGKGSGQISAVIWTTTPWTLPSNRAIALNSELEYQLVQFGDERVILATELVEAVQKVTGVEQVEVLGSAKGSDLELMRFNHPFYDFSVPFILGDHVTTDGGTGLVHTAPDHGLDDYIVGQKYKLEMAGLVANDGKFISTTPFFAGKGVFETNDLVLEKLKETGALLKLERIKHSYPHCWRHKTPIIFRATPQWFIGMETQGLRKQALGEIKRVRWIPSWGEARIDTMVANRPDWCISRQRTWGVPMTMFVHNETEQLHPRTLEILEEVAKRVEQAGIQAWWDLDPKEVLGEEDAKIYRKVPDTLDVWFDSGSTYASVVQQRPEFNGNSADMYLEGSDQHRGWFMSSLMLSTATDNKAPYNQVLTHGFTVDEKGRKMSKSLGNVIVPSEVWNKNGADILRLWVASTDYTGEIAVSHNILNSAGDTYRRIRNTARFLLANLNGFDPKRDLVKPEEMIALDRWAVSCALDAQNDIKEAYDNYQFHTVVQRLMRFCSIEMGSFYLDIIKDRQYTTKADSLARRSCQTALWHISEALVRWIAPILSFTADEIWGYLPQVEGRSEFVFTEEFYTDLFGLSESDKLDDNYWQKLLKVRAEVNRVLEQARNDKLIGAALEAKVTVYANDDIRPLLEQLGNELGFVLITSQAIVKPLAEADVAEGELAGLAVKVERADGEKCPRCWHYATDIGANAEHAEICGRCVENVVGEGETRNFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAP_SALA4
Sequence: MKNLIAELLLKLAQKEEESKELVAQVEALEIIVTAMLRNMAQNEQEMLIRQVEGALEGVKPDASVPDHDTELLRQYVKKLLRHPRH
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate and magnesium starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_MYCTA
Sequence: MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRRAVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVLGLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTEIDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CCD89_MOUSE
Sequence: MPQEEKTLRMDTPPPDEILGKQNENLQNQDEELGFKEMDGLREALANLRGLSEEEKGEKAMLRSRIQEQSQLICILKRRSDEALERCQILELLNSELEEKRLQEMEKLKAQSEHIQKLENHFMILASNHEQMIRFKDAHKSENVKLKEENARLRQENNSLFSQALKDQEAKVLELTTLNKALVEELEVLKQRCAHEASQAQAREEELLGLQNQQACDHAKETEELRSQLQSIKQQHQQATEQMGKEQEANLNLNQELQARLQTVLREKEELLQLSMERGKVLQNKQAEIRQLEEKLETAAMAKKHALERFEQEAVAVDSNLRVRELQRRVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNAKLRHLFP
What are the official names of this protein?
Coiled-coil domain-containing protein 89, Bc8 orange-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CCDC89 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1.
Protein: USPB_CITK8
Sequence: MISTVALFWALCVVCIVNMARYFSSLRALLVVLRGCDPLLYQYVDGGGFFTSHGQPNKQMRLVWYIYAQRYRDHHDDEFIRRCERVRGQFILTSALCGLVLISMVALLIWH
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRAY_SACEN
Sequence: MKSILVGAAVALVVSILFTPYLIRVFSRQGFGQEIREEVQQSHAAKRGTPTMGGVAILVAMWAGYLVAHLTVTDEPPTASGLLVLGLTTALGIVGFLDDFIKIRKQRNLGLNKTAKLVGQLVASVLFAVLAMQFANQNGITPASEHLSFIRDITVISFGSVGFVIFAYIAISGWSNAVNFTDGMDGLAGGTAAMVLAIYVVISFWQFRNNCSAPNGPALACYTVRDPLDIALVAGAAMAACVGFLWWNAAPAKIFMGDTGSLALGGLLAGLSMVTRTELLMIIIGGLFVVEALSVVMQIVVFRSTRRRLFRMAPFHHHFELAGWAETTVIIRFWVLAAISAMFGLGLFYADWLSLAREFF
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.