PharMolix/UniProtQA huggingface dataset:
Protein: BDNF_ERYJY
Sequence: SCMKAAPMKEVGVRGQGSLAYPGLRTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQAIQPSKENKDADLYSTRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSXRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSFVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPPP1_AGRFC
Sequence: MGDQSIISALLLGIIEGLTEFIPVSSTAHVLLAGHFLGFKSPGNTFAVLIQLGAILAILLVYFQKLVSIAVAMPTSAKARRFVLAVLVAFLPAAVIGALAHDFIKTVLFETPMLICVVLIIGGFILLAVDRMPLKPKYTDIMDYPPSLAFKIGLFQCLAMIPGTSRSGATIVGALLMGTDKRSAAEFSFFLAMPTMLGAFVLDLYKNRDALSFDDSALIAVGFVAAFVSGLFVVRSLLDFVSRRGFAPFAWWRIVIGALGLVALLVIG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADM_META3
Sequence: MRALIIGRWQPFHNGHLSIIKEISNEVDEIIIGIGSAQKSHSLDNPFTAGERIMMIIKSLKKYNFPYYVIPIKDIEFNAVWVSYVEALTPPFDIVYSGNALVKELFEEKGYEVRKPKLYNRTEYSGTEIRKRIINNEDWKHLIPNGVINVIDEIDGENRIKRLNMKDYDIIE
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase, NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCOB_BACSU
Sequence: MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVMLQSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAILGGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSLPLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS
What are the official names of this protein?
Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B, OXCT B, Succinyl-CoA:3-oxoacid CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase subunit B family.
Protein: TBC3G_HUMAN
Sequence: MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
What is the function of this protein?
Acts as a GTPase activating protein for RAB5.  Does not act on RAB4 or RAB11 (By similarity).
What are the official names of this protein?
TBC1 domain family member 3G.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Associated with lipid rafts.
Protein: CRGA_TROW8
Sequence: MSRKKHESSENNPVWFPTIMFGLMGTGAVWMVLFYISNGALPLPAVGTWNILIAFGIIMAGFAMMSRWK
What is the function of this protein?
Involved in cell division.
What are the official names of this protein?
Cell division protein CrgA.
What is the protein family that this protein belongs to?
Belongs to the CrgA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SERC5_RAT
Sequence: MSARCCAGQLACCCGSAGCALCCGCCPKFRQSRSTRFMYLFYFTLVIIPCCVMMSPSVMKQMTEHIPFFEDFCKGIKAGDTCENLVGYSAVYRVCFGMACFFFVFCVLTFKVNNSKSCRASIHNGFWFFKLLLLGAMCSGAFFIPDQETFLNVWRYVGAVGSFFFICIQLLLIVEFAHKWNKNWTAGTVRNKLWYASLSLALIMYSIAVGGLALMAVFYTQWDDCMDNKILLGVHGGLCVLISLAAISPCVQNRQPHSGLLQPGLISCYVTYLTFSALTSKPEKVVKDEHGKNVTICVPDFGQDFRRDESMVTWLGTLLLVVCISYSCLTSTTRSSSDALQRRYGAPELEVARCCFCFGPDGEDTEEQQNVKEGPRVIYDEKKGTVYSYSYFHFVLLLASLYVMMTLTSWFHYENATIETFFVGSWSIFWVKMASCWMCVLLYLWTLVAPLCCPSRQFSV
What is the function of this protein?
Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity).  Enhances the incorporation of serine into phosphatidylserine and sphingolipids.  May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
What are the official names of this protein?
Serine incorporator 5, Developmentally regulated protein TPO1.
What is the protein family that this protein belongs to?
Belongs to the TDE1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells.
Protein: PNP_CAMC5
Sequence: MQYSIEVNNQVEIFDLNKVAKQAAGAVMLRVKNTVVLATVARDDVQVEEDFLPLTVQYIEKAYAAGRIPGGYVKRETKPGDFETLTARIIDRSLRPLFPKGYAYPTQIVVMVLSADPEVDLQVVGLNAASVALYLSDIPVNRPVCGVRVGYIDDKFVINPSNSELKSSALDLYVAGTKDELLMIEMRSIAQQSSQIIPIIAIDPMMDPSLNDSITQKQDMNEFSEDRIVEAIDFAGKAILRASNAYEEAFKEHKKEDAILELKPEIENENIAIYIDKFYKNDVKNAINQMAKSERASELGKIAKQIASDEVAQKEGWEEGVISNVLGKYKKKIVREQIINEGVRADGRALDEVRPISIETNVLPNAHGSCLFTRGQTQALVVATLGTDGDAQMYDILTEKTALIEKFMFNYNFPGFSVGEASPLKAPGRRELGHGNLAKRALAPSIDINSPYTIRLVSEILESNGSSSMASVCGGALALRAAGVDTQKLVAGVAMGLIFEGDKHAVLTDIMGLEDHDGDMDFKVAGSSDGITALQMDIKLGGISLEVLKEALYQAKRGREHILNLMHQADSKIEVNEDVLPKLELFSVDPSKIVDIIGQAGKTIKEIIERFEVSIDLDREKGEVKIAGGAKKNVDAAKDYIISITSKENSRGFGKKPHGHDRRDKDRQKPTFNIGDEFDGVVKSVVDFGAFIELKDGVDGLLHISKIKTPLNVGDRLKVCVSEQKGNKISLSLVE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSK_ECO57
Sequence: MQNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPARELPDELLALVDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREEIDAFLDRQR
What is the function of this protein?
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium.  The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
What are the official names of this protein?
Ribokinase, RK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAHS5_HYPEX
Sequence: MATKESKYERVEKVNVDADGATLVKNIGEDRGKEDPGMNFQDKRPANLVPGAPAGVIPNRIESLPTDRAGQRLREHLSESERLRVSRSSTSSKSSSFVEPSLKYRGEIGPIGKNGEFVASSNRQNSSSNVSSSDNSERASPASRNSNPGMNNGMTTQRTTVITESSVQGLGAQRTVPIQPHQQREDHEVITHESHARAPETTVVTIPTTRFESAQLESRRDGRTYTEDKELTIPAPVVAPQIHAHQQVNMSGGTSATIHATTDLHLASEAQINDMGPEEYERYRAKVEALARIHEDETSRKAAAYRNAVEADAELIRQTLERQHMRDIEFRKDLVESSVDRQQQEIRLEAEYAMRALEQERVNARAALDQAMASTNIDVNIDSAIGTTHSQGRVTTTSESRTSQARGPATAAVI
What is the function of this protein?
CAHS proteins are cytosolic heat soluble proteins that seem to contribute to the anhydrobiosis in tardigrades, but their specific mechanisms are yet to be identified (PubMed:28306513, PubMed:33545053).  It is possible that protection during anhydrobiosis might occur via the stabilization of vitrifying small molecules such as sugars, but not via the direct glass transition of CAHS proteins themselves (Probable).
What are the official names of this protein?
Cytosolic-abundant heat soluble protein 89226, CAHS 89226, Tardigrade-specific intrinsically disordered protein CAHS 89226, TDP CAHS 89226.
What is the protein family that this protein belongs to?
Belongs to the Cytosolic-abundant heat soluble protein (CAHS) family.
Protein: ATPB_DESHY
Sequence: MNIGKIVQIMGAVVDVEFASEALPEIYSAVKVTVPEQKIDLTLEVAQHLGNNTVRCVAMSSTDGLQRGMAALNTGAPITVPVGPATLGRIFNVLGKAIDNGEEVHTDTSYPIHRPAPAFVDQDPSTVMLETGIKVIDLLAPYSKGGKIGLFGGAGVGKTVLIQELINNIAMEHGGLSVFAGVGERTREGNDLWNEMRESGVIDKMAMVFGQMNEPPGARLRVGLTGLTMAEYFRDVQNQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGALQERITSTRNGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLNRAISEKGIYPAVDPLDSNSRILSPQIIGEEHYKVARDVQQILQKYKELQDIIAILGMDELSEDEKLVVSRARRIERFLSQPFHVAEVFTGSPGKYVPIKETIRGFKEIVEGKHDNLPEAAFHMVGTIEEAIEKAKALGA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MAP21_ASPTN
Sequence: MGSKTPDGHRQSPDASNSSELKPASPNPKPSQNGSQSADLDRGVVGEDDDDDDENEEVGVITTNAEKKKKRKKSKKKNKKSKSGAAPATQQTTPPRVPLSTLFPSGYPVGELVPYENTARTTDEESQYNSRLWDEDLLTDYRQAAEIHRQVRQYAQAELIKPGASLQSIAEGIEDGVRALCGHQGLDTGDALKAGMGFPTGLCLNNIAAHWTPNPGGKDVILEKSDVLKVDFGVHINGRIVDSAFTVAFDHTYDNLLTAVKEATNTGIMVHVFLDDLVGSEVMESYEVDLAGKTIPVKAIRNITGHDILRYNIHGGKQIPFIKNNNPDKMEEGEVFAIETFGSTGKGVLDDDIGIYGYGRNANVPGSHLRLASAKSLLKTIDANFGSLVFCRRYLERLGVKSYHLGMKNLIDNGIVESYAPLVDVKGSYTAQFEHTILLHSGGKEVISRGEDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGDS_HUMAN
Sequence: MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFPV
What are the official names of this protein?
dTDP-D-glucose 4,6-dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
Protein: VP33B_HUMAN
Sequence: MAFPHRPDAPELPDFSMLKRLARDQLIYLLEQLPGKKDLFIEADLMSPLDRIANVSILKQHEVDKLYKVENKPALSSNEQLCFLVRPRIKNMRYIASLVNADKLAGRTRKYKVIFSPQKFYACEMVLEEEGIYGDVSCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALHLLSTLYGPFPNCYGIGRCAKMAYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKCGSVDFGPEVTSSDKSLKVLLNAEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRRRGMDIKQMKNFVSQELKGLKQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPEHLLTFSNLRRAGLLTEQAPGDTLTAVESKVSKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNLIPRVDGEYDLKVPRDMAYVFGGAYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKEDKASSESLRLILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLMEAMSEVKA
What is the function of this protein?
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.  Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (PubMed:28017832).  Mediates phagolysosomal fusion in macrophages (PubMed:18474358).  Proposed to be involved in endosomal maturation implicating VIPAS39.  In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753).  Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 33B, hVPS33B.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome. Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis- infected macrophages and associates with phagosomes (PubMed:18474358).
Protein: NRDI_STAAT
Sequence: MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: YQGF_RICAH
Sequence: MIIKNLQAFSRLLILNSPLIAIDYGSKKLGIALSNQERSIAMPLNTITEINKKIVITSLLSIVEKYKVCGVVIGMPIDMSGAVTEQTNMVMKFAEEFTKSINLPIYLQDERLTTKAANNFLKSFGMKRKDRDNNDDAVAASMILETVLDSMKNI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_MARMS
Sequence: MTQDELKQAVAKAAMAYIQPMLEADTIVGVGTGSTANLFIDELAKHKGLFDGTVASSEASAERLKKHGIPVYDLNSVDSIRVYVDGADESNDNLHLIKGGGAALTREKIVAACSDEFVCIADESKLVKVLGDFPLPVEIIPMARGHVARELVKLGGDPVYREGVVTDNGNHILDVYNLEILDPIALEKSIDGIVGVVTNGLFAKRSADVLLLATKEGIKTLKK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: EF1A_GIAIN
Sequence: STLTGHLIYKCGGIDQRTIDEYEKRATEMGKGSFKYAWVLDQLKDERERGITINIALWKFETKKYIVTIIDAPGHRDFIKNMITGTSQADVAILVVAAGQGEFEAGISKDGQTREHATLANTLGIKTMIICVNKMDDGQVKYSKERYDEIKGEMMKQLKNIGWKKAEEFDYIPTSGWTGDNIMEKSDKMPWYEGPCLIDAIDGLKAPKRPTDKPLRLPIQDVYKISGVGTVPAGRVETGELAPGMKVVFAPTSQVSEVKSVEMHHEELKKAGPGDNVGFNVRGLAVKDLKKGYVVGDVTNDPPVGCKSFTAQVIVMNHPKKIQPGYTPVIDCHTAHIACQFQLFLQKLDKRTLKPEMENPPDAGRGDCIIVKMVPQKPLCCETFNDYAPLGPFAVR
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, 14 nm filament-associated protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_GEOUR
Sequence: MRIGHGYDVHKLVENRKLILGGVDIPYERGLLGHSDADVLLHAISDAILGAIGEGDIGKHFPDTDPAYKGADSIKLLMHVMALAVGKGYAIGNLDATIVAQRPKLAPHIPQMRENIARALKADADRINVKATTTEELGFAGRGEGIAAYTVVLLERK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PANB_RUEST
Sequence: MSASSQKTALTAEDIRAMKGRTPIVSLTAYTTPMAQLMDEHCDFVLVGDSVGMVLHGLPSTLGVTMEMMILHGAAVARGLKRAMMVIDMPFGSYEQSPAQAFANAARLMAETGAAAVKLEGGEEMADTIRFLVKRGIPVMAHIGLTPQSINTLGGYKVQGRDDAAKPLIADARAVAEAGAFAVVLEKVPASLADQVTEIVDIPTIGIGASAGCDGQVLVVDDMLGFFGAFKPKFVKRYAELGPAAEEAIADYASEVRARRFPSAEHTFADHAPQKAPQQD
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18A_DROME
Sequence: MRAKGLLKEYEVVGRKLPSEKEPQTPLYKMRIFAPDNIVAKSRFWYFLRQLKKFKKTTGEIVSIKQVYETSPVKIKNFGIWLRYDSRSGTHNMYREYRDLTVGGAVTQCYRDMGARHRARAHSIQIIKVDSIPAAKTRRVHVKQFHDSKIKFPLVQRVHHKGNRKLFSFRKPRTYFQ
What are the official names of this protein?
60S ribosomal protein L18a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: Y114_NPVOP
Sequence: MATPVSYSFVQRMVVNELEFLNANVNSNGVGYFSFNHLGDRLQSLLTTLNNVAANADPYLQKCDARSLKLLLDNLNKISFTHNVESKPQLKQRLLDMLPNGDAIGNKYDKELNKILNFTYNCRLDTLNNIEMTHMKLTCVLCYTAGLPFRDNLWYLPNNESGELFATAFGNYLAYFLAMMRSKDGSLDKNVRVMYHVVPPLQLSEPPYIVFRDRINAGLISVQDSAQYQTAGLDFEVCYTLNNKLYLNSPGSQQTELCAEYLELNALPYCLYNATLPDNFALSALNLYKLNDAKKKLKLGNVLFVNTMRTGAKETIIATMRAYYYACKYAKANKLLRVIGNYKGYANDYKLAALDFAILMLVTNSTNIQLKYLTMNVHERMFMELKQQVCRLSPRKIYNVLLNYDIGSEPLTNFSRDAADGAFD
What are the official names of this protein?
Uncharacterized 48.2 kDa protein.
Protein: NUOCD_METCA
Sequence: MAAPTTEHAETIVPALCRRFGGETFVQQTTADGISTLWLPARILVETIRYLRSEIDRPYALLFDLTAVDERVRKHRDGMPASAYTVVYHLVSLERNADVRLKIALPETDPALPSIVAVCPAANWYEREVWDMFGIRFDGHPNLRRLIMPPTWQGHPLRKDHPARATEMEPFSLPDDVQQQEQEALRFVPEEWGMQRQSEDTDFLFLNLGPNHPSVHGVFRVALQLDGEEIVDAVPDIGYHHRGAEKMGERQSWHSYIPYTDRIDYLGGSMNNLPYVMAVEKLAGIEVPERARVIRVMISEFYRIASHLLFYGTFAQDVGQMSPIFYMFIDRERVFEIIESFTGARMHSSFFRIGGVAMDLPEGWDRLIREFIAYFPRRLAEYDKAVMANKLIQRRTRGIGAYTTTEAIDWSVTGAGLRATGLPWDYRKARPYSGYENFEFDVPTGTNGDCYDRCAVRVEEMRQSLRIIEQCVEHMPSGPYKAEHPLTTPPPKERTMHDIETLIQHFLSVSWGPVIPPGEVCVTIEATKGLNGYYLTSDGGTMSYRTRIRTPSFPHLQMIPLMSRGMMVADLIAILASIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRM1_METST
Sequence: MDTHIIEEGLVKIEVPDFEKVSAKAPVFYNPVMEMNRDISVAVINQYRKEVDHDISICDAFGGTGIRGARYSKEIHGVEKVVVGDVNPLAVEISKKNMQLNNISNVEVQKNDANILLQSNKGLFDVVDIDPFGTPAMFTQSTAANIRPGGLICISATDTSALCGTYHDPCLRKYGAKPLKTEYCHENGIRILIAFISRNLAVNQKYLHVLFSHSTEHYMRVYAIVKRGGKKTNKALDNIGFIAHCPNCLHRETTYGFAPKIPHTCPECGGEYDVAGPLWLGKIWDKEFIYNTMELVKNLNLNKKDDLMSLFEKCYMEADGPVTFYDIHKICKKLKISSPKINDVMDEIRNRGYFISRTHFKLTGMRTDMPLDELKQLILDIKEDKLGPEK
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: HFQ_BRADU
Sequence: MAADRAQNLQDTFLNHVRKTKTPLTIFLVNGVKLQGIVTWFDNFCLLLRRDGHSQLVYKHAISTIMPGAPIQLFEGGEDQPA
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: COAE_BACC1
Sequence: MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVERGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRQKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPRTQLERLMKRNDFSEEEATARIQSQMPLEEKVKRADEVINNDGTIMETKTQLEVILKNWNIID
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT1_WALAE
Sequence: MSSGGLLLLLGLLTLWAELTPVSGRPGLCELPAETGPCKARIRAFYYNPHSHKCLEFTYGGCKGNANNFKTIDECNRTCVG
What is the function of this protein?
Snake venom serine protease inhibitor.
What are the official names of this protein?
Protease inhibitor 1, Kunitz inhibitor KIn-I.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: SIR5_PONAB
Sequence: MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKLFAKAKHIVIMSGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPIEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALARHENETVS
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins.  Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting.  Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species.  Activates SHMT2 by mediating its desuccinylation.  Modulates ketogenesis through the desuccinylation and activation of HMGCS2.  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.  Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
What are the official names of this protein?
NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, SIR2-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.