PharMolix/UniProtQA huggingface dataset:
Protein: BEX4_HUMAN
Sequence: MESKEELAANNLNGENAQQENEGGEQAPTQNEEESRHLGGGEGQKPGGNIRRGRVRRLVPNFRWAIPNRHIEHNEARDDVERFVGQMMEIKRKTREQQMRHYMRFQTPEPDNHYDFCLIP
What is the function of this protein?
May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability.
What are the official names of this protein?
Protein BEX4, BEX1-like protein 1, Brain-expressed X-linked protein 4, Nerve growth factor receptor-associated protein 3.
What is the protein family that this protein belongs to?
Belongs to the BEX family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Nucleus. Cytoplasm. Note=Also localizes to microtubules.
Protein: TXAG_ALLOP
Sequence: GGCLPHNRFCNALSGPRCCSGLKCKELSIWDSRCL
What is the function of this protein?
Insect-selective toxin causing rapid but reversible paralysis in crickets.  Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel (Cav).  Induces instantaneous reversible paralysis when injected into crickets.
What are the official names of this protein?
U2-agatoxin-Aop1a, U2-AGTX-Aop1a, Agelenin.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: YBEY_NEOSM
Sequence: MLEIRITDPRWTKKLKNLDALLQKALECCLEGKKAEFSVVLTDDEFIRTLNKSYRGRDTPTNVLSFNYTNEQIGIGIIGEVILSFDRLVIEALENEIKFEDHLLHMFIHGVLHVLGYDHSSDRETLAMEKKEEEILKKLALLG
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHL_YEAS1
Sequence: MEMTHYEKTPLIRQVFNNGKTNSWFYVKHEILQPGGSFKSRGIGHLIRKSNEEALSEGSGKLAVFSSSGGNAGLAAATACRSMALNCSVVVPKTTKPRMVKKIQSAGAKVIIHGDHWGEADEYLRHKLMAQESQHGSKTLYVHPFDNETIWEGHSTIVDEIIEQLKENDISLPRVKALVCSVGGGGLFSGIIKGLDRNHLAEKIPVVAVETAGCDVLNKSLKKGSPVTLEKLTSVATSLASPYIASFAFESFNKYGCKSVVLSDQDVLATCLRYADDYNFIVEPACGASLHLCYHPEILEDILEQKIYEDDIVIIIACGGSCMTYEDLVKASSTLNVS
What are the official names of this protein?
L-serine dehydratase, L-serine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_LEPVR
Sequence: MEKSWFNLMFSKGELEYRGELSKAMDSFAPSEKTTLSQDRFIYDMDKNFYGWGERSSYSTNVDLLVSSKDIRNFISDDTFFVRDGNKNSYSIYFDIKKKKFEIDNDLSDLEFFFYSYCSSSYLNNRLKGDNDLHYDPYIKDTKYNCTNHINSCIDSYFRSHICIDSNFLSDSNNSNESYIYNFICSESGKIRESKNYKIRTNRNRSNLMSSKDFDITQNYNQLWIQCDNCYGLMYKKVKMNVCEQCGHYLKMSSSERIELSIDPGTWNPMDEDMVSADPIKFHSREEPYKNRIDSAQKTTGLTDAVQTGTGQLNGIPVALGVMDFKFLGGSMGSVVGEKITRLIEYATNQRLPLILVCSSGGARMQEGSLSLMQMAKISSVLCDYQSSKKLFYISILTSPTTGGVTASFGMLGDIIIAEPYAYIAFAGKRVIEQTLKKAVPEGSQAAESLLRKGLLDAIVPRNPLKGVLSELFQLHAFFPLKKNEIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: PDXJ_PROM5
Sequence: MATLGVNIDHIANVRQARRTVEPDPVQFAFLAELGGADSITVHLREDRRHIQDRDIFLLKETIKTKLNLEMAATEEMLKISKKLLPDFVTLVPEKREEVTTEGGLNVKNNQRYLKDYVTSLKSSNIEVSAFIDPLSEQINSSAEIGFDFIELHTGKYSELKGQERYVELQKIIESTHYAFDLGLVVNAGHGLNYQNAEKIASINNINELNIGHSIVARALAVGLERAVSEMKALISTN
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_MICAN
Sequence: MTDVPVSRIRNFSIIAHIDHGKSTLADRLLQITGTVAQREMKEQFLDNMDLERERGITIKLQAARMDYTAKDGQKYVLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKIDLPSAEPERVAAEIEEVVGLDCSEAIRASAKAGIGINDILESIVQLVPPPQDTLEEPFRALIFDSYYDAYRGVIVYFRVMDGRVKKGDKIRFMASGKEFVIDELGILSPQQVQVNELHAGEVGYLAAAIKTVADARVGDTITLTAKPAQEPLPGYTEAKPMVFCGLFPTDADQYADLKDALEKLKLNDAALSYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYNLDLITTAPSVVYQVTTTDGEIVEVDNPSLLPSPQKREKIEEPYIQVEMITPETYVGALMELCQSRRGVFKDMRYFTKTRTALIYELPLAEVVTDFFDQLKSRSRGYASMEYQLIGYRENELVKLDIMVNGDPVDALAMIVHRDKAYYVGRALTEKLKELIPRHQFKVPIQAAIGSKIIASEHIPALRKDVLAKCYGGDISRKKKLLDKQAKGKKRMKAIGTVDVPQEAFMAVLKLDPQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACT_PHYME
Sequence: MEDDIQAVVIDNGSGMCKAGFAGDDAPRAVFPSIVGMPKHLGIMVGMNQKDAYIGDEAQAKRGVLTLRYPIEHGIVTNWDDMEKIWSHTFYNELRVAPEEHPVLLTEAPLNPKANRERMTQIMFETFNVPAMYVNIQAVLSLYASGRTTGCVLDSGDGVSHTVPIYEGYALPHAIVRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLTYVAMNFDEEMEKAARSSTLDKSYELPDGNVIVIGNERFRTPEVLFKPSMIGRECTGVHECAFQTIMKCDVDIRRDLYNNVVLSGGSTMFPGIGDRMTKEMTKLAPTAMKVKIITPPERKYSVWIGGSILASLATFQHMWISKTDYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NTPPA_LACP7
Sequence: MYQIVLASGSPRRKEILSQVGINFTVCVSNMEEITSETLPENIVMELSKMKAHDIAKQYETNTIIIGSDTIVAYKNQILGKPKNEDHAKEMLQLLSGVTHEVYTGVTVIIKNDSGEVEERTFFEISKVTVSDLTEEEIMDYIKSKEPMDKAGAYAVQGRFAAHVTRIEGDYYTIVGLPIARLYQEVKKFGIDLVKQM
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPAL2_MOUSE
Sequence: MAAPARTAPEDDASAVLDELSRNFTYWAPGPGNGSLSSAWYRRNQIHLFGVLLAILGNLVISISLNIQKYSHLHLAQKEHPKPYFKSVLWLSGVLLTALGETGNFAAYGVAPITLIAPLGCMSVTGSAIISVLFLKENLRASDLLGMTLAFAGTYLLVNFAPNITQAISARTVQYYFVGWQFLVYVILEILVFCILLYFHKRKGMKHIVVLLTLVALLASLTVISVKAVSGMITLSVTGKMQLTYAIFYIMLVIMIASCVFQVKFLNQATELYTMTTVVPVNHVFFTTSAIIAGIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNREKEHLQQSFVDLGDIPGKQMLDKVQPDSNGLSYGTLPDGGDSTRGQCGEKKES
What are the official names of this protein?
NIPA-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CTL4_MOUSE
Sequence: MGRKQNENEAHGNSAKYDPSFRGPIKNRGCTDIICCVLFLIFILGYIIVGLVAWVYGDPRQVLYPRNSTGAYCGVGDNKDKPYVLYFDILSCAAAINIISIAENGLQCPTPQVCVSSCPLAPWAVEVFQFSKTVGEVYGERRNFCLPAVSPDMIVEESLQKGLCPRFLLPSTPALGRCFPLPNINFTLPEDLRINNTTVSNGISGLLDSINARDVSVKIFEDFAQSWYWILVALGVALALSLLFILLLRLVAAPLVLLLIVGVLAVLAYGIYHCWQQYQVFRDKGASITQLGFTTNFSAYQSVKETWLAALIVLAVLEGILLLMLIFLRQRIRIAIALLKEASRAVGQMMSTMFYPLVTFVLLVICIGYWAVTALYLATSGQPQYIYWASNTSTPGCENVPVNMTCDPMAPLNSSCPNLKCVFKGYSTTGLAQRSLFNLQIYGVLGLFWTVNWVLALGQCVLAGAFASFYWAFHKPRDIPTFPLSSAFIRTLRYHTGSLAFGALILSLVQIARVILEYIDHKLRGSQNPVARCIICCFKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVLRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIKGLGKDFENPNLNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERNDGSQERPYYMPKALLKILGKKNEAPTGGKTRKK
What is the function of this protein?
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity).  Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411).
What are the official names of this protein?
Choline transporter-like protein 4, Solute carrier family 44 member 4, Thiamine pyrophosphate transporter 1, mTPPT1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Apical cell membrane.
Protein: UREF_YERPP
Sequence: MNASDLIRIMQFGDSVLPVGAFTFSNGVESAIQTGIVHDVATLKGFVLTALKQAASCDGMGVVVAHRAVVADDRDGIIRADWAVNNRKLNEESRLMATRMGKKLAEMSIHVVEHPLISWWLEQIKNGNTAGTYPVTQAVVMAAQGIGQREVVVMHQYGVAMTILSAAMRLMRVTHFDTQHILFELNHDIEKFCDIAEIGDINQMSSYVPIVDVLAAVHVKAHVRLFSN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_BRASB
Sequence: MNDLKSIIGKVATGAPLSREEAASAFDSMMSGEATPSQMGALLMALRVRGETVEEITGAVSVMRAKMLRVDAPAGAVDIVGTGGDGSGSVNVSTCAAFIVAGAGIPVAKHGNRALSSRSGAADVLAALGVKIDLKPDQVGRCVQEAGIGFMFAPAHHPAMKNVGPTRVELATRTIFNLLGPLSNPAGVKHQMVGVFSRQWVEPLAQVLKNLGSKAAWVVHGSDGLDEITLTGPTFVAALEHGQIRTFEVTPEQAGLGLCGSDGLKGGDAAANAVALQSVLDGMPSPYRDVALLNAAAALVVAGRAKTLAEGVAIGRDALDSGAAAARLKHLIAVSNS
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: ERA_GEOSM
Sequence: MSEKKFRSGFVSIVGRPNVGKSTLLNRILGEKLMITSDKPQTTRNRIKGIHNVPGGQIVFIDTPGIHRAKSRLNKFMVDEALSSVQGVDLILFLVDGAVDPEKEAGMIKEVLSGVDAPVILVMNKIDLVPKGELLERMSCYGDTYPFKEIIPVSAGTGDGVEQLVQLVHGLLPEGPCYFPDDILTDVPERFIVAEIVREKIFRLTHDEVPYSTAVVVDSFKERENGVVAISATINVERDSQKGIIIGKRGDMLKRIGTQSRQEIERLLDTKVFLELFVRVSGEWSDNSRMLKEFGYE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: COX2_CYPCA
Sequence: MAHPTQLGFKDAAMPVMEELLHFHDHALMIVLLISTLVLYIITAMVSTKLTNKYILDSQEIEIVWTILPAVILVLIALPSLRILYLMDEINDPHLTIKAMGHQWYWSYEYTDYENLGFDSYMVPTQDLAPGQFRLLETDHRMVVPMESPVRVLVSAEDVLHSWAVPSLGVKMDAVPGRLNQAAFIASRPGVFYGQCSEICGANHSFMPIVVEAVPLEHFENWSSLMLEDA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NAGB_ECOUT
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: DNHA_NOCS1
Sequence: MSVTSQTSSSGSAAVSDCHRGIIDISGPVPGYEWEPSMTTEPVRGRVWTITDGVFRTLAIEGDTGVIAVDTFWSPGSARQYRRALQSHFPRKPVHTIIYTHDHLDHTGFGADFAPDADQILAHELTAEVIARRSSDGQLPATRTWSGERLEVSIDGAEFELIYPGPTHGTGNTALYFPNERFLYMADTVFTGPTYNIVPDFLWTSWIPNTRRLLGLDWDLYVPGHFWRLSRREFEADFELWDATAACALDALRAGVDIDNFADVKKFTYERMDEPFGSRTFRFDEFAAINVLTHMVHYQTGGWGLRDYEPYSNEPFKTTLPQRLGSPL
What is the function of this protein?
Involved in the degradation of 2,4-dinitroanisole (DNAN), an insensitive munition ingredient used in explosive formulations as a replacement for 2,4,6-trinitrotoluene (TNT).  Catalyzes the removal of the methyl group from 2,4-dinitroanisole (DNAN) to yield 2,4-dinitrophenol (2,4-DNP) and methanol.
What are the official names of this protein?
2,4-dinitroanisole O-demethylase subunit alpha, DNAN hydrolase subunit alpha, DNHA.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: RL21_PHOPR
Sequence: MYAVFQSGGKQHRVSEGQTLRLEKLEAETGANVEFDCVLLVANGEEVTVGAPFVTGGKVTAEVVTHGRGDKIKVVKFRRRKHSRKQMGHRQWFTEVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: MUKF_HAES1
Sequence: MLETSQTIPELVNWTREREFSLSLSTERLAFLLAIAIYNNERLDGEMLETDLIDIFRHISNTFEQSAETISTRANNSINELVKQRFLNRFSSEFTEGLSIYRLTPLGVGVSDYYIRQREFSALRLSVQLSIVADEIQRASEAAEEGGDEHYWRKNVFAPLKYSVAEIFDSIDLSQRMMDENQQHIKEEIAELLTKDWQTAIASCERLLDETSGNLRELQDTLNAAGDKLQSQLLRIQDCVIGHDNLYFVEQLIVDLQAKLDRIISWGQQAIDLWIGYDRHVHKFIRTAIDLDKNRVFSQRLRQSIHHYFDHPWFLWIAQAERLIDLREEELTLREEEALGELPEELQYESLADLHEQIVETMQSLLIEYRLQNTPIDLSEVLTAQLKQYPLAKHFDIARIIIDQAVRLGLAQDDLNGIYPNWRSINENGAEVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: PYRG_NITMU
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISGKMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITDEIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMAVQLPREDTCFIHLTLLPYITSAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDVDSIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDLTESYKSLSEALIHAGIHTRSKINIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGKIMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHSTEFHPETAYPVIALTIEWRSREGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRLEQAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVFADKSPSSEGAISADKPERTTTGAYIQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SIGS_STAAB
Sequence: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNFYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKFLNHRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKTSVKRKCQHNFK
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).
What are the official names of this protein?
RNA polymerase sigma factor SigS.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: NUOD_NEOSM
Sequence: MTVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPYFDRLDYVSPMAQEHAYSLCVEKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVGAMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAADIPDGLDEEIMSFLESFTHKLDDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLDFAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSMEALIHHFKLYSEGYHVPEGETYFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQALDTLSRKHLLADVPAILGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATL18_ARATH
Sequence: MISMLFPRSPLCTAAIVFYTCVCIPLGRLKKNGGDADAHDDDGYNLVGVMFGDKEKEEEICCPICLVEFEAEDAVTHLPRCAHLFHINCIEPWLLRGHLTCPLCRSFVLAPTPPTQNVNNAHSSSTLYLSIFFFFCIFLHLLGYL
What are the official names of this protein?
RING-H2 finger protein ATL18, RING-type E3 ubiquitin transferase ATL18.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLYA_JANSC
Sequence: MNAPHRDETTASHRDDGFFTESLESRDPEIFAASQKELGRQRDEIELIASENIVSAAVMEAQGGVMTNKYAEGYPGRRYYGGCQYVDIAEELAIDRAKQLFGCDFANVQPNSGSQANQGVFTALLQPGDTILGMSLDAGGHLTHGARPNQSGKWFNAVQYGVREGDLEIDYDQIAALAAEHKPKMIIAGGSAIPRIIDFARMREIADTIGAYLLVDMAHFAGMVASGHYPSPFPHAHVATTTTHKTLRGPRGGMIVTNDEAIAKKVNSAIFPGIQGGPLMHVIAGKAVAFGEALRPEFRDYQTQVIANAQALAAQLIKGGLDIVTGGTDTHLMLVDLRAKGVKGNATEKALGRAHITCNKNGIPFDTEKPMVTSGLRLGSPAGTTRGFGEAEFRQIADWIVEVVDGLAANGEDANDAVEAKVRGEVQALCDRFPIYPNL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANED_ASPA1
Sequence: MMSAAICTLLAVIATTSLGLLFLSIIRRGKLPPGPPPKPIVGNLHQFPKVNRAQVFDQWHRTYGPIVGLRLGLKKLILVGSYQVARELLDRRGAIYSSRPRVVMAGEIANRGNHTALMPYGPKWKLHNRVHSALMNPTMVKRYQYLQDIESRQLVHDLLQGSTSDFGARIHRYSSSLLFALAYGRRLPTSDAFEIQENAHIAHQFINNLAAGRWLVDAFPVLNYLPTWLAPWKKIGEQLYQRKFGLLQRHTALALEKPVWNWTKHFHGPKKPAEASWEELLNIIGVLYEAGADTTTSALEAFVMAAVLHPDAVRRVQAEIDALVGGAARMPSFEDVQQLPFVDAFVNETMRWRPIAPEGVPHSLMKEDEYEGFTIPKNSIVIANQWHMAMDPATFTDPQAFRPERWLEDPKLPISAFGFGRRACPGRHIALNSMKIVMCRLLWAYDFDHAYENGRKVTIDPDNFVREGVLSKPAPFKAALRVRSPAHEKTIQSALRESEQDEDKILAHIAAGLA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin (PubMed:31618514).  The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate (PubMed:31618514).  The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D (PubMed:31618514).  Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E (PubMed:31618514).  The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation (PubMed:31618514).  The monomodular nonribosomal peptide synthtase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A (PubMed:31618514).  The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety (PubMed:31618514).  Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway (PubMed:31618514).
What are the official names of this protein?
Cytochrome P450 monooxygenase aneD, Aculenes biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.