PharMolix/UniProtQA huggingface dataset:
Protein: CP19A_HUMAN
Sequence: MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247).  Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561).  Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid.  Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874).  Also displays 2-hydroxylase activity toward estrone (PubMed:22773874).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874).
What are the official names of this protein?
Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein.
Protein: SYP_MYCSK
Sequence: MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVRPVGPGLYTWLPLGLRVFRKIEQIVRDEMTAIGGQEILFPALLPRAPYETTNRWTEYGDTLFRLKDRRDNDYLLGPTHEELFTLTVKGEYSSYKDFPLILFQIQTKYRDEARPRAGILRGREFVMKDSYSFDVDDDGLKTAYHLHREAYQRIFARLGVHYVIVSAVSGAMGGSASEEFLAESEVGEDTFVRCLQSGYAANVEAVLTRVPEPLPIEGQPEAVVYDTPDAPTIATLVDWANGADLPNFAGRAVTAADTLKNVLVKVREPGGEWELLAVGVPGDREVDDKRLGAALEPAEYALLDEADFARHPFLVKGYVGPKALLDNGVRYLVDPRVVDGTAWITGADAPNKHVVGLVAGRDFVADGTIEAAEVRDGDPSPDGAGPLVSARGIEIGHIFQLGRKYTEAFSADVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQQHDELGLRWPAAVAPFDVHVVIANKDDGARTGATELAGELDRLGLEVLLDDRKSSPGVKFKDAELLGVPWIVVVGRGWGDGVVELRDRFSGEKREIGVDDAATEILATVR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOC2A_ASPNC
Sequence: MSTSTTFQIHYFASASTYTGKQTERLPAPLPLPQLFDTLESMYPGIKEKVLTSCGVSLGDEYVDVEADIQVMIHPGDEVAVIPPVSSG
What is the function of this protein?
Acts as a sulfur carrier required for molybdopterin biosynthesis.  Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group.  In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by uba4.  After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
What are the official names of this protein?
Molybdopterin synthase sulfur carrier subunit, Common component for nitrate reductase and xanthine dehydrogenase protein G, Molybdenum cofactor synthesis protein 2 small subunit, Molybdenum cofactor synthesis protein 2A, MOCS2A, Sulfur carrier protein MOCS2A.
What is the protein family that this protein belongs to?
Belongs to the MoaD family. MOCS2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS26_BOVIN
Sequence: MCPGNWLWASVTFMARFSRSGSRSPVRVRGALEEPPAVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQEIANNHRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSVHFQAAADFIHRALSQPGGRILVHCAVGVSRSATLVLAYLMLYHRLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA
What is the function of this protein?
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.
What are the official names of this protein?
Dual specificity protein phosphatase 26.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Golgi apparatus.
Protein: PYRF_BACC1
Sequence: MSQSLIVALDFPGKQDVEQFLRHFEGEELFVKVGMELFYKEGPAIITYLKEKGHKIFLDLKLHDIPNTVKSAMRSLASLDVDMVNVHAAGGSSMMKAAIEGLEEGKQEGKERPICIAVTQLTSTSEAMMKKEIGIEKTLEEAVAHYAKLTKESGLDGVVCSTLEVPKLREVCGNEFVTVTPGIRLASDDVNDQVRVATPKRARELGSSYIVVGRSITKAENPLEAYKTVKQQWEGVTV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: MNTH_AGRFC
Sequence: MFFMRMICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYLVAVGYMDPGNWATSLAGGSKFGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRDAYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIPLELGVLITALDVFLILYLQKLGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATFNKTGQTNVAELGEAHSLLAPLLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKMRLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQVVLSLQLSFAVFPLVMFTSDKAKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FTSY_RICPR
Sequence: MITIFNKLKQSLSKTSNTISAGIDKIFYKRKLDKETLNELEELLISSDISISVVTHIIEEFKNVKFDKTIDSDTVKEAIAKLIEQQLSKSEIPFTLSENKLNIILVCGVNGVGKTTTIGKLSALYSAEGKKVAVAACDTFRAAAINQLSSWVHRANALLITGKASADPASVAYRAIEESIKQNIDILFIDTAGRLHNNKNLMDELSKIVKVIKKLDENAPTHSILIIDAITGQNTYNQIEYFNDVTNLTGLIVTKLDGSAKAGVLVGAVQKFNLPVYFIGIGEKIEDLKIFNRHDFSRSLVGL
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).  Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: BOLMP_THEPX
Sequence: MIKLKRLSDKPVLMPKAENEWERAAVFNTAAIYDNGLFHLIYRATDIGPHAKYGKYISRLGYAVSKDGINFMRLDKPVMSNETEQELRGLEDPRIVKIDGIYYMMYTGFGDRFQDDYRICLATSKNLIDWERKGVVLDEPNKDASLFPEKINGKYVMLHRRYPDIWIAFSDDLKNWYDHKPILKPIPNTWESARVGIGGPPIKTKDGWFLIYHAADDNNVYRLGAVLLDLEDPSKVIARQKEPILEPELGWEKEGYIPNVVFSCGNAVKDDTIYVYYGGADTVIGVAILEMKDIKF
What is the function of this protein?
Probably involved in a salvage pathway for GDP-D-mannose biosynthesis (PubMed:25500577).  Catalyzes the reversible phosphorolysis of 1,2-beta-oligomannan.  In phosphorolytic reactions, prefers 1,2-beta-oligomannan with a degree of polymerization (DP) of 3, 4 and 5.  Produces alpha-D-mannose 1-phosphate, which is the precursor of GDP-D-mannose (PubMed:25500577).
What are the official names of this protein?
1,2-beta-oligomannan phosphorylase, 1,2-beta-oligomannan:phosphate alpha-D-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 130 family.
Protein: TRMN6_SHEHH
Sequence: MPFTFKLFHVDDSRCGMPVSTDGVLLGAWAPLVQAKTILDIGAGSGLLSLMAAQRSQAKITAIELDNDAALDCQQNFDASHWSERLEIICCDIQAYCQREQARQFDHIICNPPYFANGPQSSKFSRATARHTDSLSFDALLQAIKQLLAPEGQASLILPTESVSLLEAILSTYNLRLCHKLLAASVEGKAPNRQILVLGHDLKAKKIHNFGTELQAVAQQQLYIREKTGHYSLAFTLLSQDFYLKL
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_LEGPA
Sequence: MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHVLVKQNPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MQO_KOCRD
Sequence: MTSPQPTETADVVLVGAGIMSATLATLLNDLQPEWRMLVLERLDAAGLESSNAWNNAGTGHSALCELNYAPQAADGTVSAEKALTINEQFQVTRQMWSSLVENGTLEDPNTFINPVPHVSMVFGDDHADYLRARYDAFKPNKLFERMEFTEDRDLIAQWAPLTMHGRGAGRVAATFAPEGTDVDFGALTNQLLNHLQGRNITVEYGQEVTTLDRQSDGSWLVSVVDRLNSDNNRVIRAGFVFLGAGGGALPLLQKSKIKEAKGYGGFPVSGLFLRNTDPTVTAQHNAKVYGQASVGAPPMSVPHLDTRYVNGRRAIMFGPYGGFKPNFLKHGSLLDLPKSVRAHNLYPMTRAGMANLDLVKYLVGELTKTRSQRIDALHEYYPTAEESQWELIEAGQRVQVMKSDPQKGGVLQFGTELVTSADGSIGALLGASPGASTAVPIMLNLLSKCFPAKMSEWEPRIKELIPAYGRKLNDDPRLTDEIMGHTASVLGIK
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: ARL3_RAT
Sequence: MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRSYFENTDILIYVIDSADRKRFEETGQELTELLEEEKLSCVPVLVFANKQDLLTAAPAAEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  Required for normal cytokinesis and cilia signaling.  Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms.  Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E.  Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity).  Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 3, ARD3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. Present on the mitotic spindle (By similarity).
Protein: Y1903_BREBN
Sequence: MSSLDNTMKFTVPKEANTADVQETLTEVYKALQEKGYNPITQIVGYLLSGDPAFIPRHNNARSLIGKLERDKIIEELVTVYLSERK
What are the official names of this protein?
UPF0297 protein BBR47_19030.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: TGT_LISMO
Sequence: MSAIRYELIKTDKQTGARLGKIHTPHGTFDTPMFMPVGTLATVKTMSPEELKAMGAGIILSNTYHLWLRPGEELIREAGGLHKFMNWDQPILTDSGGFQVFSLSKMRDIKEEGVHFRNHLNGDKLFLSPEKAIQIQNALGSDIMMSFDECPPYPASHEYMKKSVERTSRWAERGLKAHVRPEDQGLFGIVQGGAYEDLRAQSAKDLVSLDFPGYSIGGLSVGEPKDVMNRVLEHTTPLLPANKPRYLMGVGSPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSSGRLVIKNAKFTHDFRPIDENCDCYTCKNYSRAYIRHLIRCEETFGIRLTTYHNLHFLLNLMKQVRGAIMEDRLADFREEFFEQYGFNRPDAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ISPE_RHOJR
Sequence: MLSVVPRPVVVRAPSKVNLHLAVGDLRDDGYHELNTVFQALSLSDTVSVAPAETLSVTVRGEDARVVPTDSSNLVWQAAEMLAAESGRRPDVEIAIDKGIPVAGGMAGGSADAAATLVGLNALWQLDLSREELDGFAAKLGSDVPFSLHGGTAVGTGRGERLLPVLSRSTFHWVLALAKVGLSTPTVFRELDRLRADGNPPRLGGPEDLMHALTTGDAATLAPLLGNDLQSAALSLNPGLRRTLRAGVAAGALAGIVSGSGPTCAFLCAEADAAVRVSAELAGAGVCRTVRVASGPVPGARIINDAAEGSH
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PROA_CHLTE
Sequence: MTEHEAIVKQLQAVQNASRKIVPLNEETINGLLVELADRIPAAADAILEANRKDLERMDPADPRYDRLLLNEARLNSIATDLRNVAALPSPLHRVLEERTLPNGLELKKVSVPLGVIGIIYESRPNVTFDVFALCLKSGNATVLKGGSDAAYSNIAIVNLIQTVIRDRGLDPDMIYLLPAEREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDQSGDLAMGRDIVFNAKTRRPSVCNALDTLIVHESRIDDLPVLVVPLEEKNVQIFADEPAYYKLLGRYPDELLEMASPEHFGTEFLSLKMSIKTVGSLEEALNHIARHSSKHSEAIIASDQTTIDAFMKQVDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELCSYKWLVTGQGQVRTA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP1_NOTTY
Sequence: MARYRHSRSRSRSRYRRRRRRRSRYRSQRRRYRRHRRSGRRRRRGRRRGYRRRYHSHRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL14_CLOBM
Sequence: MIQQQTRLKVADNSGAKEIMCIRVLGGSHRKWGNIGDVIVASVKSATPGGVVKKGEVVKAVIVRSVKGLRRADGSYIKFDENAAVIIKDDKNPKGTRIFGPVARELRDKEFNKILSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: DYL2_HUMAN
Sequence: MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
What are the official names of this protein?
Dynein light chain 2, cytoplasmic, 8 kDa dynein light chain b, DLC8b, Dynein light chain LC8-type 2.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RS5_ALCBS
Sequence: MVMAKVDPNEGLQEKLVQVNRVAKVVKGGRIFGFTALTVVGDGKGKVGFGRGKAREVPAAIQKALEAARRNMIQVELNGTTIQHPMKARHGASKVYMQPADEGTGVIAGGAMRAVLEVAGVQNVLAKCYGSTNPVNVVRATFNGLKSMASPESVAAKRGKSVDEILN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PTH_MYXXD
Sequence: MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVEPQTFMNLSGRSVAEAARFFKVPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSSLGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERREMDALIDRAMDMTELWIREGLSVAMNRFNRKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4M_AVACL
Sequence: MLKIIIPTIMLFPVTWYSKNSMIWINTTSHSLMISLMGLLLLNHPSNNSNNFSLNFFSDPLSSPLLMLTMWLLPLMIMASQHHLAKEPWFRKKSYLSMLITLQMFLIMTFMATELILFYILFEATLIPTLIIITRWGNQTERLNAGMYFLFYTLTGSLPLLVALIYLQSSMGSLNLLTINLWLKELPNSWSTNLLWMACIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITIILDPTTKSMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILVQTPLGFMGATALMIAHGLTSSMLFCLANSNYERIHSRTMLMARGLQTLLPLMTTWWLLASLNNLALPPSINLIGELLVTITSFSWSNITVILIGLNMLITALYSLYMLITTQRGKLTYYLHNLNPSLTRENTLMSMHMLPLLFLTLNPKIILGPTF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HDHA_ECOLI
Sequence: MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGGVQELN
What is the function of this protein?
7alpha-hydroxysteroid dehydrogenase involved in the metabolism of bile acids.  Catalyzes the NAD(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as the major human bile acids cholate and chenodeoxycholate, to the corresponding 7-oxosteroids.  To a lesser extent, can also act on taurochenodeoxycholate, taurocholate and glycocholate (PubMed:2007545).  Can also use glycochenodeoxycholate as substrate (PubMed:8672472).  Is not able to use NADP(+) instead of NAD(+) as the electron acceptor (PubMed:2007545).
What are the official names of this protein?
7alpha-hydroxysteroid dehydrogenase, 7alpha-HSDH, NAD-dependent 7alpha-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: THIC_XANOM
Sequence: MNAAPTVLQQQAQSLSEAVTQPIPGSRKIFVQGSRADLQVPMREIALTRTPTLFGGEENPPLSVYDTSGPYTDPQVAIDLAVGLAPLRAHWIAERGDTVALDGLSSSFGRGREHDARLDAVRFPARRLPRVAREGANVTQMHYARRGIITPEMEYVAIRENQRLEAVTDASLRKQHPGEAFGASIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVDGRAEALTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICQIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGAQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYAAEHGMDDAQALSTGMQEKSAQFLAQGAQVYRPM
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PRRP3_ARATH
Sequence: MKLKKPSLPSSLLCAVPPCLSQIRLLIPRRVRVSSSTFANAKLVTLRNHTVNLHIYYCSMAGTDNRRSRHDDESPKNPNKKKKGNRNPEKSLLINLHSCSKRKDLSAALALYDAAITSSDIRLNQQHFQSLLYLCSAFISDPSLQTVAIDRGFQIFDRMVSSGISPNESSVTAVARLAAAKGDGDYAFKLVKDLVAVGGVSVPRLRTYAPALLCFCDTLEAEKGYEVEDHMDASGIVLEEAEISALLKVSAATGRENKVYRYLQKLRECVGCVSEETSKAIEEWFYGVKASEVSDNGIGSDIELLRAAVLKNGGGWHGLGWVGEGKWIVKKGNVSSAGKCLSCDEHLACVDTNEVETEDFVNSLVTLAMERKAKMNSCEPMADFSEFQEWLEKHGDYEAILDGANIGLYQQNFADGGFSLPQLEAVVKELYNKSGSKKQPLILLHKKRVNALLENPNHRNLVEEWINNNVLYATPPGSNDDWYWLYAAAKLKCLLVTNDEMRDHIFELLSNSFFQKWKERHQVRFTFVKGCLKLEMPPPFSVVIQESEKGSWHVPITSQDKEESLRSWMCITRQSS
What is the function of this protein?
Endonuclease RNase P responsible for the 5' maturation of tRNA precursors.  Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).
What are the official names of this protein?
Proteinaceous RNase P 3.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Nucleus.