PharMolix/UniProtQA huggingface dataset:
Protein: AL3A1_MOUSE
Sequence: MSNISSIVNRARDAFNSGKTRPLQFRVEQLEALQRMINENLKGISKALASNLRKNEWTSYYEEVAHVLDEIDFTIKGLSDWAEDEPVAKTRQTQEDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAIAAGNAVVLKPSEVSDHMADLLSTLIPQYMDKDLYPVIKGGVPETTELLKEKFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNEIVEKLKKSLKDFYGEDAKQSHDYGRIINDRHFQRVINLIDSKKVAHGGTWDQPSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLDEAIKFINQREKPLALYVFSNNDKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVRSLRNEEANKARYPPSPAKMPRH
What is the function of this protein?
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable).  They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable).  Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108).  Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860).  Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860).  May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761).
What are the official names of this protein?
Aldehyde dehydrogenase, dimeric NADP-preferring, Aldehyde dehydrogenase 4, Aldehyde dehydrogenase family 3 member A1, Dioxin-inducible aldehyde dehydrogenase 3.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_SALG2
Sequence: MAKGIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MFAL2_YEAST
Sequence: MKFISTFLTFILAAVSVTASSDEDIAQVPAEAIIGYLDFGGDHDIAFLPFSNATASGLLFINTTIAEAAEKEQNTTLAKREAVADAWHWLNLRPGQPMYKREANADAWHWLQLKPGQPMY
What is the function of this protein?
The active factor is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A).  It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type a cells and synchronizing them with type alpha.
What are the official names of this protein?
Mating factor alpha-2, Alpha-2 mating pheromone.
Protein: RHAM_ECOLC
Sequence: MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARNLLFAMVEIESEERWNAVASTDVCQRWWKYMTDVMPANPDNSPVSSELQEVFYLP
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_NEIG2
Sequence: MLQTDNLTAAQPQRIVAAQTASAQEELLERALRPKTLDDYIGQHKAKEQLAIFIQAAKKRGEALDHVLLFGPPGLGKTTLAHIIAKELGVNLRQTSGPVLERAGDLAALLTNLDPHDVLFIDEIHRLSPVVEEILYPALEDYRLDIMIGEGPAARSVKIDLPPFTLVGATTRAGMLTNPLRDRFGIVSRLEFYENRDLTTIVSRSAQLLQLDMGEEGAMEVAKRSRGTPRIANRLLRRVRDFADVKNNGVIDAAVADAALSMLDVDAQGLDVMDRKFLEAVLHKFGGGPVGLDNVAAAIGESTDTIEDVIEPYLIQQGFLQRTPRGRMATERAYLHFGLPVEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: IPI1_CANGA
Sequence: MTKSKKQKQKKKDFLKKKLKVGKPTGKPSNSTDTSFTARTLSVRSQLVNNAGDDLRKRLPLLKHHNDKVRKETLGIYIKAIPKIISTQLMTPLISQTSQLICDDSKDVREQLLELFDEVGKHDEQVLKLHCRSLVLYINMGMTHILPRVQADSTKFLGCLLKYCGQEFCDQAWNKLMAGIFRVLSWETQHSKNSNQAAGAMQTSKRDNKFQAAHLSTLYALLECGCKEPTVETTDEDTTSNIQNFEEVQYMTPSFPQAYGYLKLFDKQLKSSSSNKDNSSVSSSDALDVESRIRNVENVYLPTMKKQIEQIIQEGGEAGKNANNIKKLISEIFS
What is the function of this protein?
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
What are the official names of this protein?
Pre-rRNA-processing protein IPI1.
What is the protein family that this protein belongs to?
Belongs to the IPI1/TEX10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMG_STRPN
Sequence: MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTALRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTEIQPGDEVPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGLENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMKRMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEGKNRSISKTLQKSK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP26C_HUMAN
Sequence: MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL
What is the function of this protein?
Plays a role in retinoic acid metabolism.  Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
What are the official names of this protein?
Cytochrome P450 26C1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: THIE2_AQUAE
Sequence: MELPRLYAITDRKKYGENFLETLEKILKKGVRMVQLREKDLKDRELYKLAKEVRALTKKYKALLLINERFDIALAVEADGVHLPEQSFPPSVVKRVNPNFIVGFSAHSLESAKYAEKEGADFITLSPIFKTSSHPEAQPIGLKTLKEVSEKVNIPVYALGGITWEKIKVCYKNGAYGIAGISMFLE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Putative thiamine-phosphate synthase 2, TP synthase 2, TPS 2, Thiamine-phosphate pyrophosphorylase 2, TMP pyrophosphorylase 2, TMP-PPase 2.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: PRX3_PENRF
Sequence: MLSLKAFLALSLSIHLSQGLVASVSHRRANACTELSRSYPDSTIHPGSSVFAEDVIEPWSQTCQTTPTCVFAPASAEEVAGGLAILRKADQTFAVRTQGHMPIPGAADISNGVLMVTTSLNSVQYADDSKSVVQIGAGNRWLDVYKVLAKDNLAVVGGRFGQVGVSGLLLGGGISYFNSDHGWGANSVVNYEVVLANGTVCAANAQQNSDLYWALKGGSFNFGIVTRFDLATFSVPYMWGGSAFYDASALDPLVNAYASYAVASGGSSDPAAHSDPSILYNVTTGEVSGYGIYMHRGDDPAPAALKNFTDIPSTFQDFRVGKTILGLENDTTPVNFGVGNRRQLFSSTALASSAEAVYLVNQTFFDVIAANPQIKTTTDLSVTNTYQLFTPGMIRAAKASGGDPIGLYDPLGNGVLAVLYGGNWADAKDDEIIYKFFQDMIDELDNRAKKLGLYYDFVYLNDAAPTQTKDIFQKFSNGTALPKLREIAESYDPDQVFQTLTPGGFKLINSPA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF6 is probably also involved in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
FAD-dependent monooxygenase prx3, PR-toxin biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: OXLA1_DABRR
Sequence: ADDINPKEECFFEDDYYEFE
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:18384385).  Is active on L-Met, L-Ile, L-Leu, L-Phe, L-Trp, and L-Tyr (PubMed:18384385).  Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation.  Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation.  These different effects are probably due to different experimental conditions.
What are the official names of this protein?
L-amino-acid oxidase L1, LAAO-L1, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: THI4_FERNB
Sequence: MSMKDLKISQLIVKHYFQKLNDVLNVDVAIAGCGPSALALATELAKNGRKVAIFEAKNEPGGGIWGGGMMFNELVLESELEWYLKEHHIKYKKEDEFIVVDAVHFASAMLYNATKNGAYIFNNVFVEDLVMYNERISGVVINWMPTIKEKLHVDPITVVAKFTVDGTGHPANLVRLLSKRGIINSVKGSSENLCSCGVVEYEFPMDAENGEKFVVENTKEIYPGLYVMGMAAVSVGGGPRMGPIFGGMIMSGLRAAELIEEELKRIETSEDKMWVRV
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: RLMN_LEGPA
Sequence: MDQQKVNLLNYNYSQLRELLIAWDEKPFRAQQLFQWIHQVGICDFAQMTNLGKVLRNKLSQLACIDLPEIVACQKSADGTHKWLLKLECGNCIETVFIPEANRGTLCVSSQVGCALNCSFCSTAKQGFNRNLSTAEIIGQVWLAARELSDNNGTHDKKITNVVMMGMGEPLLNFDNVVSAMNIMMDDLAYGLSKRRVTLSTSGVLPEMERLREVSPVALAVSLHAPTDELRNELVPINKKYPLSQLISLCKRYFKDEPRRKVTFEYVMLKGVNDQPEHASQLIKLLHNVPAKVNLIPFNPFPLTQYQRSSRETIDAFRDKLMKHGINTITRKTRGDDIDAACGQLAGEVKDKTSRSQRWQKLHFMSKTEKSTELTISSEEIA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTU1_CRYNB
Sequence: MPPTPCSLCHTARALVKRPKTGQQVCKDCFFEVFETEVHNTIVEGEGIFKRGERVAIGASGGKDSTVLAHVLSVLNKRYDYGLDLYLLSIDEGITGYRDDSLETVKQNQAEYGLPLKILSYSELYGWTMDKIVEQVGKKNNCTFCGVFRRQALDRGAAQLGVDHIVTGHNADDIAETVLMNIMRGDIARLARCTAVTTQSEDTIKRSKPFKYAYEKEIVMYAYFKKLTYFSTECIYSPDAYRGHARVFLKDLEAVRPSAIVDIIHSGESFVLEQSVQRGMKALQTCLRCGYISSNDLCKACALLEGLESGLSRSALRQTQESTSAAPEGHRTIPMFERYASLNGTPRTPPTPAEPVEGIERAA
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_BORPD
Sequence: MKCPFCGNADTQVVDSRVSEEGDTIRRRRRCLSCDKRFTTYERIELAMPSVVKRNGSRSDYDTAKLRASLSLALRKRPVSTDQVDSVVARIEETLLASGQREVSTERIGELVMAELKKLDKVGYVRFASVYKNFEDIGEFVDAIREMQGPMLPGKLRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CIA30_PONPY
Sequence: MALVHKLLRGTYILRKFSKPASALYPFLGIRFAEYSSSLQKPVASPGKASSQRKTEGDLQGDHQKEVALDITSSEEKPDVSFDKAIRDEAAYHFRHLKDEIVDHWRGPEGRPLREVLLEQAKVVWQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQSALLYGTLSSEAPHDGESTRSGYCAMISRIPRGAFERKVSYDWSQFNTLYLRVRGDGRPWMVNIKEDTDFFQRTNQMYSYFMFTRGGPYWQEVKIPFSKFFFSNRGRIRDVQHELPLDKISSIGFTLADKVDGPFFLEIDFIGVFTDPAHTEEFAYENSPELNPRLFK
What is the function of this protein?
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
What are the official names of this protein?
Complex I intermediate-associated protein 30, mitochondrial, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1.
What is the protein family that this protein belongs to?
Belongs to the CIA30 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix. Note=Periferally associated with the matrix face of the mitochondrial inner membrane.
Protein: MIAA_STAAS
Sequence: MNKNKPFIVVIVGPTASGKTELSIELAKRINGEIISGDSMQVYKHMNIGTAKVTPEEMDGIPHHLIDILNPDDTFSAYEFKRLAEDLITDITNRGKVPIIAGGTGLYIQSLIYNYELEDETVTPAQLSIVKQKLSALEHLDNQQLHDYLAQFDAVSAENIHPNNRQRGLRAIEYYLKTKKLLSNRKKVQQFTENYDTLLLGIEMSRKTLYSRINKRVDIMLDHGLFREVQQLVEQGYESCQSMQAIGYKELIPVINGQMIYEDAVNDLKQHSRQYAKRQMTWFKNKMSVHWLDKENMSLQMMLDEITTQIK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: IP5PA_ARATH
Sequence: MSDPLYIFNRSQSEIVVESLLASSNLRSSMPTQQIQSLRVFVATWNVGGKSPHSGLNLDALLHVHSEFDVYVLGFQEIVPLNAGNVLVLGDNEPAAKWLAMINQSLNKSSSSSGGRLSPKTPSFGAGSMFFAKPSLKKISESFRTECRRKLKICNCSTFSEDIVRKYGRESCFRCPEGLVNQSGVLSDDEEDEDDDDDDEDEDEGGGKVASLVSNQMTMKYGLVASKQMVGIFLTVWMRKELIQHVSHLRISSVTRGIMGCLGNKGCIAVSLQLYKTSFCFICSHLASGEREGDERRRNLDVIEILKNTSFPRICRTSFTRVPDRITKHDRVIWLGDLNYRIALSYSETKTLLDKNAWDTLLNKDQLKIERDAGRVFKGWHEGKIFFAPTYKYSYNSDAYAGDTSKEKKNKRRTPAWCDRILWHGDGIRQLSYVRGESRFSDHRPVCSVFVVDVEVCEGKTGTRRQ
What are the official names of this protein?
Type I inositol polyphosphate 5-phosphatase 10, At5PTase10.
What is the protein family that this protein belongs to?
Belongs to the inositol polyphosphate 5-phosphatase family.
Protein: IR06_HCMVM
Sequence: MTLIYVDADNTRNELKATTGSNFTITHRKDPLTTKWKTVFGNNGDQWLCNVTGIGNATVNGNATICVSSCGHNTLDLCNLKSGDSGFFDLSRWFGENMDEYSGDVWHLEVS
What are the official names of this protein?
Uncharacterized protein IRL6, TRL6.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 IRL6 protein family.
Protein: MURB_ANAMF
Sequence: MSYGFVAYNLPKVQGTYRRGVKMHNATWFNVGGVAEVVFKPSSVEDLAAFVRDTNLPISVVGVASNLIVRDGIVKGVVVKLGREFSYINCNGNIITAGCATLLSNLAVAAQESGISGLEFFVGIPGTVGGAIEMNAGAYGGDVASVLRSVRAVNEHGEICTLSNDDMRYSYREHGLVGKWIFVDATFVGACGDRDAIKGTMREFIARRNDSQPVRGRTGGSTFKNPEGHQAWELIDKAGCRGLQIGGAQVSEKHCNFLLNCGGATAKDLEDLGNEIRCRVHSMFGIKLEWEIRFLGCGL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_BORBR
Sequence: MIRRLLIAPIRFYRYFLSPWVGRQCRFTPTCSAYAIEAIERHGAWRGLWLAARRIGRCHPWSPGGYDPVPPGHGAGAQACCAHRHRTEPD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CDC2B_ANTMA
Sequence: AYGVVYKARDIETNEDIALKKIRLEQEDEGVPSTAIREISLLKEMHHENIVNLKDVVHREKRLYLVFEYLDLDLKKHMDSCPEFSQDLHMVKMFLCQILRGVAYCHSHRVLHRDLKPQNLLIDRGSNTIKLADFGLARAFGIPVRTFTHEVVTLWYRAPEVLLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELHKIFRIIGTPNEDIWPGVTSLPDFKSSFPKWPPKELATIVPNLGATGLDLLCKMLQLDPSKRITAKKALEHEYFKDIVLP
What is the function of this protein?
Plays a key role in the control of the eukaryotic cell cycle.
What are the official names of this protein?
Cell division control protein 2 homolog B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: ILVC_DICTD
Sequence: MAKVYHDTEVSLEALKDKIVTIIGYGSQGRAHALNLRDSGIKVIVAVRPNGESWKRALEEGMTVEKIEDAVQKSDVLMFLIPDTEQPTIYKEKVLPYLRPNQALGFAHGFNIHFSQIVPPPFLDVFMVAPKGPGPLVRDLYVEGKGVPALFAVYQDYTQKCRDIALAYAKGIGATRAGVLETTFKEETETDLFGEQVVLCGGVTALIKAGFETLVEAGYQPEVAYYECLHEMKLIVDLINQGGISFMRKAISDTAKYGDITRGPRIVNEETKKEMRKILNEIQSGQFAKEWILENQVGRPVFNALLKKDEDHLIEKVGKVLREMMPWLKPKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: STEEP_BOVIN
Sequence: MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDGAKHAHKFCNTEDEETIYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
What is the function of this protein?
Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity).  Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity).
What are the official names of this protein?
STING ER exit protein, STEEP.
What is the protein family that this protein belongs to?
Belongs to the STEEP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected in the nucleus and cell soma of various neuronal types.
Protein: METK_CROS8
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRTDPLEQGAGDQGLMFGYATNETDVLMPAPVTYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDGGKIVGIDAVVLSTQHAEDIEQNVLHDAVMEEIIKPVLPAEWLNESTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKIATEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1462_BURTA
Sequence: MSKSSDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLESLFNRIDLKLEIEPLLHIPVYFGGPVQTERGFVLHEPVEGSSYNSSMTVEGGLEMTTSKDVLEAVATGTGPKRFLLTLGHAGWGAGQLEEEISKNGWLTVAADPRIVFDTPAEERFEAALGLLGVSSSMLSGEAGHA
What are the official names of this protein?
UPF0301 protein BTH_I1462.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.