PharMolix/UniProtQA huggingface dataset:
Protein: ENH1_PANTR
Sequence: MIFAGKAPSNTSTLMKFYSLILYSLLFSFPFLCHPLPLPSYLHHTINLTHSLLAASNPSLANNCWLCISLSSSAYTAVPALQTDRATSPVSLHLQTSFNSPHLYPPEELIYFLDRSIKTSPDISHQQAAALLHTYLKHLSPYINSTPPIFGPLTTQTTIPVAAPLCISRRRPTGIPLGNLSPSRCSFTLHLRSPTTNITETIGAFQLHITDKPSINTDKLKNISSHYCLGRHLPCISLHPWLPSPCSSDCPPRPSSCLLIPSPENNSESLLVDTRRFLIHHENRTSPSTQLPHQSPLQPLTAAALAGSLGVWIQDTPFSTPSHLFTLHLQFCLAQGLFFLCGSSNYMCLPANWTGTCTLVFLTPKIQFANGTEELPVPLMTPTRQKRVIPLIPLMFGLGLSASTIALSTGIAGISTSVMTFRSLSNDFSASITDISQTLSVLQAQVDSLAAVVLQNR
What is the function of this protein?
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
What are the official names of this protein?
ERV-H1 provirus ancestral Env polyprotein, ERV-H/env62, Envelope polyprotein, Env protein.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I H env subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: MTNA_RHORT
Sequence: MNVKGTPTRTIWPAREGGAVWIIDQTRLPHEFVTQRLNDLGAVAHAIRAMLVRGAPLIGATAAYGVALGMAEDPSDEGLTRACQTLLATRPTAVNLRWAIEAMAESLAAVPPDQRAQAAWAKAGAICDEDVALNEAIGDHGLGIIKDLARTKGVEKGGEGPINILTHCNAGWLATVDWGTALAPLYKAHDAGLPIHVWVDETRPRNQGASLTAWELNSHGVPHTVIADNTGGHLMQHGLVDMVIVGTDRTTATGDVCNKIGTYLKALAAFDNAVPFYVALPGPTIDWTVNDGLREIPIEQRDAAEVTRVWGRTAAGALEWVTITPTGSPAANYAFDVTPARLITGLITERGVCAASAAGLAGLYPERAPAPVPAGSAAGKGAAATADGAL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (PubMed:23042035, PubMed:31950558).  Also catalyzes the interconversion of 5-deoxyribose 1-phosphate and 5-deoxyribulose 1-phosphate (PubMed:31950558, PubMed:23042035).  Part of a bifunctional DHAP-shunt salvage pathway for SAM by-products (PubMed:31950558).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: HBA_TUPGL
Sequence: VLSPGDKSNIKAAWGKIGGQAPQYGAEALERMFLSFPTTKTYFPHFDMSHGSAQIQAHGKKVADALSTAVGHLDDLPTALSALSDLHAHKLRVDPANFKLLSHCILVTLACHHPGDFTPEIHASLDKFLANVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RPO3_PYRAB
Sequence: MVEIKILKKTDDSITFILEGVDVAFANALRRTILGEVPTFAVDEVEFYENDSALFDEIIAHRLAMIPLKTPVDRFELDALELDDYTVTLSLEAEGPGIVYSGDLKSDDPDVKPANPDIPIVKLAKGQRLVFNAFAKLGRGKDHAKWQPGFTYYKYFTRIHISKEIEGWEKLKKLAKKRGLPVKENENEVIVETIKPFYIPKEFEEYEGKGIWEEIVPNTYVFVVETNGELPVEEIVKIALKILMRKADRFINELQGLAG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 11014_ASFL5
Sequence: MKVLLGLLLGYSVLILAHELPDLPRTQHPPKSELSYWCTYVPQCDFCWDCQDGICKNKITESRFIDSNHSIVNCRVFRNSMTQSCLYEISSKMPNHFSMECLHPRPYTGNEIFMRTWGGGG
What are the official names of this protein?
Protein MGF 110-14L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
Protein: ARGB_SYNP6
Sequence: MSSEFIEAGAADRVRILSEALPYLQQFAGRTVVVKYGGAAMKQEELKEAVMRDIVFLACVGMRPVVVHGGGPEINAWLGRVGIEPQFHNGLRVTDADTMEVVEMVLVGRVNKDIVSRINTTGGRAVGFCGTDGRLVLARPHDQEGIGFVGEVNSVNSEVIEPLLERGYIPVISSVAADENGQSFNINADTVAGEIAAALNAEKLILLTDTRGILEDPKRPESLIPRLNIPQSRELIAQGIVGGGMIPKVDCCIRSLAQGVRAAHIIDGRIPHALLLEIFTDAGIGTMIVGSGYHEAHQPWQ
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_XANCB
Sequence: MTVQPTTIGIVGARGHTGAELIKLIAAHPQLQLVFVSSRELAGQRVAEHSDGYQGELRYESLDADAVAAKAADVVILALPNGKAEPFVAAIDASRPQTLLIDLSADYRFDPAWYYGLPELTRHTYAGQRRISNPGCYATAMQLAITPLREQLAGPPQCFGVSGYSGAGTTPSDKNNPALLADNLMPYALTNHMHEREVSAQLGVPVEFMPHVAPHFRGITMTVNLWLQQPLTREQIHARYLERYAHEPLIEIVDEAPWVSRIAGTHGVQIGGFTVAPGNKRVVVVATLDNLLKGAATQAMQNLNLALGWDELTAIG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_YERPN
Sequence: MANIKSAKKRAVQSEKRRKHNASRRSMVRTFIKKVYAAIAAGDKDAAQKAFNEMQPIVDRQSCKGLIHKNKAARHKSNLVAQINAMQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: XERD_XYLFT
Sequence: MTLRTTNQRRQLARQQPPLLPEDATTIAHCLDALWIKHGLSRHTLNSYRRDLEGLARWNNGRAGPLATLTPPALLDYLTWRTQQHYSPLSNARLRSVLRTFFSYAVECGWRNDNPSTLLAHPVLPHPLPKALTESQIEALLAAPSIETPEGLRNRAMLELMYAAGLRVSELVTLPVAMLNQRQGVLRITGKGGKERLVPLGEESQHWLQRYLEQARPSLAADKPIPADSDGDVPLFINTNLKRLSRQQFWRWIKHYAALVGIAPNKVSPHVLRHSFATHLLNHGADLRALQMLLGHRSISTTQIYTLIARQHLQQLHAQHHPRG
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YO277_YEAST
Sequence: MTYASSSSSSLSKAANALKPRIGLSATISLVSAGLLEEIFLLFGLTFKVSWAMVATGTVEVGVVSVSSSSSSPLPFFLASNVHQPSESVVTLGLLCLIFGLP
What are the official names of this protein?
Putative uncharacterized protein YOR277C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RR7_CERDE
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDIAVKSRRVGGSTHQVPVEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FTSQ_ALCBS
Sequence: MAKNAPAPRGARRKPVKKVGVPLRERVATAVPWMLVGSVAMVSLLAVIYLPAALDGYPIRKVGVDGVTDVRRQQQIETALAALVREENYFSVPLEEIYQQSQGLSWVEEVSVRRQWPDTVVLTVEERRPVAVWNESVLVSDSGQPFKALKQYDLDDLPHLNGPEQRLEEVMGFYHSMGKTLADVDLSIRSMEVNARLTARLTLNNDMELVVDREHYTTKLRRFVRLYRGVLNTDSRQVARVDLRYADGMAVTWREQQS
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.  May control correct divisome assembly.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: FMO2_RAT
Sequence: MVKKVAVIGAGVSGLISLKGCVDEGLEPTCFERTEDIGGLWRFKENVEDGRASIYHSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVISVKKRPDFASSGQWDVYVQSNGKEQRAVFDAVMVCSGHHIQPHLPLKSFPGIERFQGQYFHSRQYKHPVGYEGKRILVVGIGNSAADIASELSKRAAQVFVSTRHGSWVLSRISEDGYPWDMVFHTRFSSMLRNVLPRTVVKWMMERQMNRWFNHENYGLVPQNKYLMKEPVLNDDLPSRLLYGAIKVKTRVKELTETAVVFEDGTVEEDVDVIVFATGYTFSFPFLEDSLVKVEDNKVSLYKAMFPPHLEKPTLACIGLIQPLGSIFPTVELQARWATRVFKGVCRLPSETTMMADIAERNEKRIDLFGKSQSQILQTNYIDYLDELALEIGAKPDFISLLFKDPKLAVKLYFGPCNSYQYRLVGPGQWEGARNAILTQKQRILKPLKTRTLQTSASAPVSFLIKVLGLLAIVLAFFFKLHGF
What is the function of this protein?
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
What are the official names of this protein?
Dimethylaniline monooxygenase [N-oxide-forming] 2, Dimethylaniline oxidase 2, Pulmonary flavin-containing monooxygenase 2, FMO 2.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: YNGB_BACSU
Sequence: MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQLLAYLEDVIKRETKEMLR
What is the function of this protein?
Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP (PubMed:33556370).  This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  the predominant glycolipid found in B. subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (PubMed:33556370).  YngB contributes to wall teichoic acid (WTA) glucosylation and glycolipid formation under anaerobic fermentative growth conditions (PubMed:33556370).  Might also enter other glycosylation pathways, leading to the decorating of other cell envelope components with glucose residues under anaerobic or other growth conditions (PubMed:33556370).
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase YngB, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, UGPase, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: TRPD_METAC
Sequence: MKGMKEYIKKLEEGSDLSSEEAEAAIGEILSTAEDEEIGAFLLALRAKGEKPQEIAGFVRGMKQAGNTIKPVTPFRVIDTCGTGGDGLNTINVSTAAAIVTAAAGVPVAKHGNRAATSMSGSSDVLEALGIKVDLTPGQVRKTIEKIGIGFMFAPVFHPAMKRVAGVRKKLGVRTVFNILGPLTNPAGAKGQVVGVFDKKLCEPIAYALAELGTEHALVVHGDGMDEISNTGETFVAELKDGEVSTYTITPEAMGMLRAKPEDIKGGTPKENARDLLCIFKGQKGPKRDLVILNAAAALYVSGIVGSIRQAIPIAEDAIDSGKVMVKFNQFRNFTAELSIQGKKEGSCPGEAFLASSDTSVLSPASGEKA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: THIC_BURP0
Sequence: MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIRAGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRNFLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIYHRQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: TMPS7_RAT
Sequence: MDKEKSDPSCKSSDLKISNISIQVVSVPGKLPGRRLPRKPIGKARPRKQPKKRAPFWNVQNKIILFTVFLFILAVTAWTLLWLYISKTDSKDAFYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVSSNNKGGLLVHFWIVFVMPHAKGHIFCEECVAAILKDSIQTSITNRTSVGTLQGLAVDMDSVVLNAGLRSDYSSAVGSDNGCSQYFYADHLTLRYPLEISATSGQLMCHFKLVAIVGYLIRLSIESIQLEADNCITDSLTVYDSLLPIRITCVLLSGYRICEPTRTLMSFVSTNNLMLVTLKSPYVRRLAGIRAYFEVIPEQKCENTILVKEINSFEGKISSPYYPSYYPPKCKCNWTFQTSLSTLGIALKFHNYSITKKSMKGCEHGWWEINEHMYCGSYMDHETIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVTAKPACNTSIFRQHGPLVCDGFQDCEDGQDEQNCTRSIPCTNRTFKCGNDICFRKQNAQCDGIVDCPDRSDEEGCGCSRSSPFLHRVVGGSDSQEGTWPWQVSLHFVGSAHCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLRQLIQPICIPPVGQRVRSGEKCWVTGWGRRHEADSKGSPILQQAEVELIDQTVCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLSCRRKSDGKWILTGIVSWGYGCGRPNFPGVYTRVSNFVPWIHKYVPSLL
What is the function of this protein?
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.
What are the official names of this protein?
Transmembrane protease serine 7, Matriptase-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: NUP54_DROME
Sequence: MSFFGSNTSLGATSTPAKTTGGLFGSPFGGTAATSQPAPAFGAQATSTPAFGAQPATSAFGAGSAFGATAAAPAFGAATGTSAFGGSAFGSTPAFGAATTTTAGTGLGGGGFGGFGAAPATSQAGLFGAPATSAAPPAFSGFGQQAAASTAPASGFSGFGTTTTSAPAFGGFGTSQSTGFGGGAFGSTFGKPANTTVTPGFGGFGGTSFMLGQPQQQPAPISADEAFAQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQSAAPVDITPENVMCRFKAIGYSRMPGKDNKLGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNMLVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRILATELSNYLNQATLKPQLNNLGVVEALALVLPDEDQLREYLENPPRGVDPRMWRQANSDNPDPTLYIPVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHATATAKILEHKRKLAELSHRILRIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFKGRLSELLSQMRMQRNQFAANGGAEYALDKEAEDEMKTFLTMQQRAMEVLSDTVNKDLRALDVIIKGLPELRQS
What is the function of this protein?
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050).  Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050).  Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346).  By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346).
What are the official names of this protein?
Probable nucleoporin Nup54.
What is the protein family that this protein belongs to?
Belongs to the NUP54 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex.
Protein: TNK1_HUMAN
Sequence: MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
What is the function of this protein?
Involved in negative regulation of cell growth.  Has tumor suppressor properties.  Plays a negative regulatory role in the Ras-MAPK pathway.  May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system.  Could specifically be involved in phospholipid signal transduction.
What are the official names of this protein?
Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: FAM50_CAEEL
Sequence: MSRADEGRLIHLAKKREREKEDIEQQLRKLEEDKEKCRVGITNKFMANYETVEEVVKSKTYGLVSLDDMKNIQKNEISNRDLQVARGDQSSSTQSKDSQEAREKEEHVAKHTQKRFLSFAFDDEEDEEDAAPIIPKKRVGMDPTVDTSFLPDKEREEFLRKKKESLAAEWRVKQDAEKNEEITVAYAYWDGSSHRKNMKIKKGNTISQCLGRAIEALKKEFTELKSCTAENLMFVKEDLIIPHFYTFQDFIVTKAMGKTGPLFVFDSASDVRIRQDAALDYGESHPAKIVLRSWYEKNKHIYPASRWEPFVPSKKYGRNFDDLSDL
What are the official names of this protein?
Protein FAM50 homolog.
What is the protein family that this protein belongs to?
Belongs to the FAM50 family.
Protein: TACY_STRCB
Sequence: MKDMSNKKIFKKYSRVAGLLTAALIVGNLVTANADSNKQNTANTETTTTNEQPKPESSELTTEKAGQKMDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDNKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQAKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGADAAEHNKVVTKDFDVIRNVIKANATFSRKNPAYPISYTSVFLKNNKIAGVNNRSEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Streptolysin O, SLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).
Protein: CITG_CITK8
Sequence: MMPIPATSTDSAAIPQTLLDAYALLAWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEYGASCAQLPSDDVLKGLRPLGMACEADMFRATAGVNTHKGSIFSLGLLCAAIGRLHQQHSPITPANICSTAATFCRGLTERELRQNNQQLTAGQRLYQQLGLTGARGEAEAGYPLVIRHALPHYRALLAQGRDPELALLDTLLLLISMNGDTNVASRGGAEGLCWIQQQATTLLRQGGIRSPADLEHLHRFDQQCIARNLSPGGSADLLIVTWFLAQISQVNHLHNY
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: SYFA_PETMO
Sequence: MALTIDRDEIIGTLKREIQEITDMQEFQNLKSKYLGKKGLIKSLMNSLKDIDDVELKKEYGKSVNELKEELETLFDEKLSELKEKEREEKEKKNWVDITIPGARRKIGKENLITKTRKEIEEIFIGMGFSVAEGPEIENSWYNFDALNTPEWHPAREMQDTFYLSLDKEKLLRTHTSPVQVRTMLKSKPPLAIISPGRVYRKDELDATHSPVFHQVEGLYVDRNVSVSHLKMYLEVFAQKFFGNKVSVLLRPSYFPFTEPSFEVDISCIFCGGKGCNVCKNTGWIEILGAGLVHPNVFQSVNYDPKVWQGFAFGMGIERVAMLKYNIPDMRELYKNDIRFIENS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAG_XMRV6
Sequence: MGQTVTTPLSLTLQHWGDVQRIASNQSVDVKKRRWVTFCSAEWPTFNVGWPQDGTFNLGVISQVKSRVFCPGPHGHPDQVPYIVTWEALAYDPPPWVKPFVSPKPPPLPTAPVLPPGPSAQPPSRSALYPALTPSIKSKPPKPQVLPDSGGPLIDLLTEDPPPYGAQPSSSARENNEEEAATTSEVSPPSPMVSRLRGRRDPPAADSTTSQAFPLRMGGDGQLQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLITHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGNDGRPTQLPNEVNAAFPLERPDWDYTTTEGRNHLVLYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDPGQETNVSMSFIWQSAPDIGRKLERLEDLKSKTLGDLVREAEKIFNKRETPEEREERIRREIEEKEERRRAEDEQRERERDRRRHREMSKLLATVVIGQRQDRQGGERRRPQLDKDQCAYCKEKGHWAKDCPKKPRGPRGPRPQTSLLTLGD
What is the function of this protein?
Involved in the packaging and encapsidation of two copies of the genome (By similarity).  Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome (By similarity).  This binding is dependent on genome dimerization (By similarity).  Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structures during gRNA retrotranscription (By similarity).
What are the official names of this protein?
Gag polyprotein, Pr65gag, Core polyprotein.
What are the subcellular locations of this protein?
[Gag polyprotein]: Virion. Host cell membrane; Lipid-anchor. Host late endosome membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. SUBCELLULAR LOCATION: [Matrix protein p15]: Virion. SUBCELLULAR LOCATION: [Capsid protein p30]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p10]: Virion.
Protein: TRHO_SALPK
Sequence: MPVLHNRISNDELKAKMLAESEPRTTISFYKYFTIASPQQTRDALYQVFTALDVFGRVYLAHEGINAQISVPQSKVETFRQQLYTFDPALDGLRLNIALEDDGKSFWVLRMKVRDRIVADGIDDPTFDASNVGDYLKAADVNAMLDDPDAVFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMLREHADKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARRAREQGLPVRFIGKNFVFDERMGERISDEVIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPQCASKFNGCCSEQCCEELALPEEEQRRRRAGRENGNKIFNKSRGRLNSKLSIPDPAE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.