PharMolix/UniProtQA huggingface dataset:
Protein: RL24_RHOP5
Sequence: MAAKIRKGDKVIVLTGRDKGRTGEVFEVRPADNKALVRGINIVKRHQKQTQAQEGGIISKEAPINLSNIAIVGKDGKPTRVGFKIQADGKKVRVAKRSGAEIDV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: FTSI1_ARATH
Sequence: MASIDNVFSLGTRFSIPENPKRSILKHATTSSFSARTQTRWRAPILRRSFTVLCELKTGSSSSGETNNSPAADDFVTRVLKENPSQVEPRYRVGDKLYNLKEREDLSKGTNAATGAFEFIKRKFDSKKKTETDKSEESVYLSDILREYKGKLYVPEQVFGPELSEEEEFEKNVKDLPKMSLEDFRKAMENDKVKLLTSKEVSGVSYTSGYRGFIVDLKEIPGVKSLQRTKWSMKLEVGEAQALLKEYTGPQYEIERHMTSWVGKVADFPNPVASSISSRVMVELGMVTAVIAAAAVVVGGFLASAVFAVTSFAFVTTVYVVWPIAKPFLKLFVGVFLGVLEKSWDYIVDVLADGGIFSRISDFYTFGGVASSLEMLKPILLVVMTMVLLVRFTLSRRPKNFRKWDLWQGIAFSQSKAEARVDGSTGVKFADVAGIDEAVDELQELVKYLKNPDLFDKMGIKPPHGVLLEGPPGCGKTLVAKAIAGEAGVPFYQMAGSEFVEVLVGVGSARIRDLFKRAKVNKPSVIFIDEIDALATRRQGIFKENSDQLYNAATQERETTLNQLLIELDGFDTGKGVIFLGATNRRDLLDPALLRPGRFDRKIRVRPPNAKGRLDILKIHASKVKMSDSVDLSSYASNLPGWSGAKLAQLVQEAALVAVRKTHNSILQSDMDDAVDRLTVGPTRIGLELGHQGQCRRATTEVGVAITSHLLLRYENAKIERCDRVSIIPRGQTLSQVVFHRLDDESYMFGRLPQLLHRLQVLLGGRAAEEVIYGSDTSKASVDYLSDASWLARKILTIWNLENPMVIHGEPPPWRKRPQFVGPRLDFEGSLYDDYDLVEPPVNFNMDDEVAHRSEELISQMYNKTVSLLRQNQTALLKTVKVLLNQKEISGEAIDFILDHYPPQTPLNSLLQEQNPGSLPFVPEHLRRESGDFVLVNHSTDVNAQV
What is the function of this protein?
Functions in chloroplast biogenesis and chloroplast division (PubMed:10417716, PubMed:22900897).  Required for plastid development during embryogenesis (PubMed:22900897, PubMed:24964212).  Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex (PubMed:12185496).
What are the official names of this protein?
Probable inactive ATP-dependent zinc metalloprotease FTSHI 1, chloroplastic, AtFTSHI1, Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 1, Protein ARC1, Protein FTSH INACTIVE PROTEASE 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: HMEN_HELTR
Sequence: QDEKRPRTAFTGDQLARLKREFSENKYLTEQRRTCLAKELNLNESQIKIWFQNKRAKMKKASGVKNQLALQLMAQGLYNHSSSSSSSSSSSSSIFLLA
What is the function of this protein?
This protein specifies the body segmentation pattern.
What are the official names of this protein?
Homeobox protein Ht-En.
What is the protein family that this protein belongs to?
Belongs to the engrailed homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YBEY_ECOHS
Sequence: MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTIRVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_MYCGE
Sequence: MNNNITNSIAQLFFNTSFFAFLFLIIIAFNLCLFAYLYFQYRIYKKNPKKANNFKANEYEKIKLLKNQNFTESNKLIATTNELNELTSQLDNILVRIINKPLAKLVNDFLDEQIKQIVKLDKNSSDFHSESDNLPFYTKLFNDFHFGVDKLININIKNPLYNWVYSPSFLISESDFRKLNGISGINKKLLVEKLRIEDIVFTDLNKKYEVNVLTESPIKAQKTVLTVRNILMNDYVDNERIESYVQQANFFFTEHCKKIGKEILESLNIFISSSSLHRHFGFLAFRYSFGQNVLSHSLETAFLTAHLAALIELDSELSLKCGLLHDIGKSNDDNGKESHTITGAKLAEQFQLPDDIKYTIANHHNKHIDNTYCRLTQIADKLSAARIGARSDSSLLFKQLKDELKKIVDKTINNFHTTILLGQSGRRLMIWLETKNQNQLLSNEQIIEMVEKIKAEIAKNPITNHFPIKVVIRYNFEHSFNTKS
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: IBP_FLAFP
Sequence: MKILKRIPVLAVLLVGLMTNCSNDSDSSSLSVANSTYETTALNSQKSSTDQPNSGSKSGQTLDLVNLGVAANFAILSKTGITDVYKSAITGDVGASPITGAAILLKCDEVTGTIFSVDAAGPACKITDASRLTTAVGDMQIAYDNAAGRLNPDFLNLGAGTIGGKTLTPGLYKWTSTLNIPTDITISGSSTDVWIFQVAGNLNMSSAVRITLAGGAQAKNIFWQTAGAVTLGSTSHFEGNILSQTGINMKTAASINGRMMAQTAVTLQMNTVTIPQ
What is the function of this protein?
Has antifreeze activity for survival in a subzero environment.  Binds to the surface of ice crystals and inhibits their growth.  Has high thermal hysteresis (TH) activity, which is the ability to lower the freezing point of an aqueous solution below its melting point, and thus the freezing of the cell fluid can be prevented protecting the organism from ice damage (PubMed:22750870, PubMed:24699650, PubMed:27737617).  The TH activity of this protein is 2. 2 degrees Celsius at 5 uM and 2. 5 degrees Celsius at 50 uM (PubMed:24699650).
What are the official names of this protein?
Ice-binding protein, Antifreeze protein, AFP, FfIBP.
What is the protein family that this protein belongs to?
Belongs to the ice-binding protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_PSYIN
Sequence: MSLSAEQKAEIVAKYGRSENDTGSSEVQAALYTAQIDHLQGHFKEHIHDHHSRRGLLRMVSQRRKLLDYLKRKDVAAYTALIAELGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RPAB5_ENCCU
Sequence: MIIPIRCFTCGKEISSKWEPYQELLKIDKGKAEALDELGMRRICCRRMFLGHVDIVDKLLKFDIVKDFTQRS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC5, RNA polymerases I, II, and III subunit ABC5, RPB10.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VP3_EHDV1
Sequence: MADPPDANVPKTSPYLKGDELSSDSGPLLSIFALQEIMQKVRQAQSEYVAATKDVDLTVPDVQKIIDGVKELASETIYKIVQKPIISYRHVVMQSRDRFLRVDTYYERMSEVGDKIDENEPAKFYETVIKKVRHLRTEGAFILHNIPTKDHRGMEIADPEILGVDVKSILPVLTAEHRAMIQHVLDGAIIENGNIATRDVDVYLGACSESVYRIYNRLQGYIEAVQLEELRRTVTWLERLGKRKRMTFSQEFLTDFRRVDTIWVLALRLPANPRVIWDVPRCSIANLIMNIATCLPTGDMFRPNPRIASITLTQRITTTGPFAILTGSTPTAQQLDDVRKIYLALMFPGQIILDLKIDPGERMDPAVRMVAGVVGHLMFTAGPRFTNITQNMARQLDIALADFLLYMYNTRIQVQYGPTGEPLDFRIGRGQYDCNVFRANFQTGTGYNGWGLVDVENREPAPYDHAQRYIRYCNIDSRELIHPATFGIGMNYHCYNEMLRMLVAAGKDTEAAFFRNMLPFHMVRFARINQVINEDLHSAFSMPDDQFNVLLANMVVGQQERVDPVILDISWISIWYAFNRSFEPIRRNEMLESAPLIESVYASELTVMKTDMQQMALLQRRFPDVLIEARPTHFWKAVMEVSPEPVRAIMDLAHSHSFINIRDMMRWIGLPSMQNSMKLVLEEEAWAVANDFEELMLTDQVYMYRDMLPEPRLDDIERFRQEGFYYTNMLDGPPAIDRVVQYTYEVARFEANMGQLRAALRRIMDDERWVRFGGVLRTVRIKFFDSRPPEEILQALPFDYQTNEKGGLTYATIKYANDTTIYYLIYNVEYSNLPDSLVLINPTYVMTKVFMNKRIVERVRVGQALAVMNKRFIAFKGKMRIMDISQALKVGTKLAAPTV
What is the function of this protein?
The VP3 protein is one of the five proteins (with VP1, VP4, VP6 and VP7) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP3.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP3 family.
What are the subcellular locations of this protein?
Virion.
Protein: TFE_METHJ
Sequence: MASHEEILADKAIFAYLHRMIGDEGIELIRRFPTDKEYSDEELAEVTKINLNSVRNTLYTLYEHRLAKYRRIKNNETGWLTYLWELELDNMYDSVSKDLEIILEKLRKRYKYESENAFYNCPNCGNTITFSDAMDSQFVCQECENKMVHFDNDLLVNALQKRIARIEENLGHV
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: FCY2_EMENI
Sequence: MAGAFDFDLEKNPPVVQSTADNSSDGAVPGETFTYGDSTYAKIQRLAAELNIEQRGIERVPAAEQTDTSVFNIGSMWLAANMVVSSFAIGVLGKSVYSLGFVDAILTVLFFNLLGIMTVCFFSCFGPFGLRQMVFSRLWFGWYVTKGFAVLNILACLGWSAANAIVGAQMLHAVNSDVPGFAAILIISICTLLVTFAGYKVVHLYEYWSWIPTFIVFMIILGTFAHSGDFQNIPMGVGTSEMGSVLSFGSAVYGFATGWTSYAADYTVYQPANRSKRKIFLSTWLGLIVPLLFVEMLGVAVMTATDIKGSKYDVGYATSGNGGLIAAVLQPLGGFGDFCLVILALSIVANNCPNFYSVALTVQVLSRYAQRVPRFIWTLFGTGVSIAIAIPGYSHFETVLENFMNFIAYWLAIYSAIAIMDHFVFKRGFSGYVVENFDKREKLPVGIAATIAFGFGVAGMITGMSQPWYVGPIARHAAGGDVGFELGFAFAAFSYLCLRPFEIKFFGR
What is the function of this protein?
This permease has a broad specificity towards purines, and also transports cytosine, but neither uracil nor thymine.  Contributes very little in purine uptake.  Its major role may be the uptake of cytosine.
What are the official names of this protein?
Purine-cytosine permease fcyB, PCP fcyB, Cytosine/purine transport protein fcyB, Fluorocytosine resistance protein fcyB.
What is the protein family that this protein belongs to?
Belongs to the purine-cytosine permease (2.A.39) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVC_BIFA0
Sequence: MIVLGVDPGLTRCGVGVIEAGAYRRLSFIHVDVVRSDPHESQDLRLLKIYDGLCAKMDEFIPDTVSIERVFAQENRNTVLGTAQAAGMAMLAAAQRGIPVALHTPTESKMAITGNGKAEKIQMERMVARILNLNALPTPADAADALAIAICHALRPSGALEGGEREQHLTPAQRQWAQATQHATRRRGVRRGM
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ATPA_ECOL6
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPLDHDGFSAVEAIAPGVIERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSFEAALLAYVDRDHAPLMQEINQTGGYNDEIEGKLKGILDSFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YHGE_ECOLI
Sequence: MDNVELSPATRWGMIATGLLQGLVCYLLIAWLSGKNHSWIVYGVPATVAFSSVLLFSVISFKQKRLWGWLALVFIATLGMSGWLKWQTDGMNPWRAEKALWDFGCYLLLMAMLLLPWIQQSLRIRNDSSRYRYFYQSVWHNVLILLVIFLANGLTWLVLLLWSELFKLVGITFFNTLFFATDWFIYLTLGLVTALAVILARTQSRLIDSIQKLFTLIATGLLPLVSLLTLMFIITLPFTGLSAISRHISAAGLLLTLAFLQLILMAIVRDPQKASLPWTGPLRCLIKTALLVAPLYVFVAAWALWLRVAQYGWTVDRLQGVLAVLVLLVWSLGYFVSIVWRKGQNPVVLQGKVNLAVSLLVLVILVLLNSPVLDSMRISVNSHMARYQSGKNTSDQVTIYMLEQSGRYGRAALESLKSDAGFMKDPKRARDLLMALDGEQHLQQQVSEKVLADNVLIAPGSVKPDATFWSALIQDRYNVMTCIEKDACVLVEQDLNSDGQAERILFAFNDDRVIVYGFDSDRKEWDALDMSLLPNEITKEKLLTAAKDGKLGTKPKAWRDLVVDGERLNVNLNE
What are the official names of this protein?
Uncharacterized protein YhgE.
What is the protein family that this protein belongs to?
To B.subtilis YrdB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MCM3M_XENLA
Sequence: MDYGGGFEDHELREAQREYLDFLDDDQDQGLYHGKVRDMIGSNEHRLIVNLNDVRRKNDKRANLMLNDAFAETIAFQRALKDLVASIDATYAKQFEEFSVGFEGSFGSKHVSPRTLTASLLGSLVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKYSDLTSLEAFPSSSIYPTKDEENNPLETEYGLSTYKDHQTLSIQEMPEKAPAGQLPRSVDIIADDDLVDKCKPGDRVQIVGIYRCLPSKQGGFTSGTFRTILLANNIKLMSKEIAPTFSADDVAKIKKFCKAHSKDIFEHLSKSLAPSIHGHEYIKKAILCMLLGGNEKVLENGTRIRGDINVLLIGDPSVAKSQLLRYVLHTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIQARLNARCSVLAAANPVYGRYDQYRTPMENIGLQDSLLSRFDLLFIVLDKMDADNDQEIADHVLRMHRYRTPGEQDGYALPLGCSVEIFATDDPNASDVTDQELQIYEKHDNLLHGPRKNKSKIVSMQFIRKYIHVAKLIKPVLTSEAADYISQEYAKIRNHDQINNDSARTMPVTARALETMIRLSTAHAKVRMSKTIERQDAETALELVQFAYFKKVLAKEKKKTDKDLHDENLSQDTLSQESVRKSSRRAGKIADSQDDSMDPYSFSEQDSSLNENLSQSLRPQRKKAESQDGKRSLSQNRTKEFKAALLKAFKSSRSQSVAVSQLLELINKGNPEPFERSEVKEALDNMQNDNQVMVSEDVVFLI
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
What are the official names of this protein?
Maternal DNA replication licensing factor mcm3, Maternal minichromosome maintenance protein 3, mMCM3, xMCM3, P1 homolog, XRLF subunit beta, p100.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
Protein: TGT_PEDPA
Sequence: MEPAIKYRLIKTDKHTGARLGEIITPHGTFPTPIFMPVGTQATVKAMSPEELEDLGADIILSNTYHLWVRPGEDIVKEGGGLHQFMNWKKGILTDSGGFQVFSLAKLRDITEEGVHFKNELNGANMFLSPEKAIQIENDLGPDIMMSFDECPPYFESYDYVKHSVERTSRWAERGLKAHRNPETQGLFGIIQGAGFEDLRRQSAKDLVSMDFPGYSIGGLSVGESKEEMNRVLDFTTQLIPENKPRYLMGVGSPDALIDGVLRGVDMFDCVLPTRIARNGTCMTSHGRLVVKNAKYARDFTPIDDNCQCYTCRNYTRAYIRHLIKTDETFGLRLTSIHNVYFLVHLMKDVRQAIMDDNLLEFRQNFFEEYGYNKENSKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SURE_METC4
Sequence: MRILVTNDDGIHAPGLETLEGIARALSDDVWVVAPETDQSGVSHSLSLNDPLRLRQIGEKRFAVKGTPSDCIIMGVAHILKDHKPDLVLSGVNRGQNVAEDVTYSGTIAGAMEGTILGIRSIALSQAYGAGGRANLKWACAATHGPRVIEKILEIGIEPGILVNVNFPDCEPEDVQGVAVSAQGQRNQALLQIDARHDGRGNPYFWLAFAKARFEPGNGTDLKAIAENRISVTPLRLDLTDEPELTRFAAAFRA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB4V_HETPE
Sequence: MKTQFTVLLITLVLFQMLSQSEAILSYLWNGIKSIFGKRGLSDLSDLDELFDGEITKADLDLLREIM
What is the function of this protein?
Amphipathic peptide with antibacterial activities (By similarity).  Shows antiviral activities against the herpes simplex virus type-1.  It potently inhibits the initial infection by provoking the rupture of viral envelop and the dissociation of proteins from the virions (EC(50) is 0. 41 uM).  It also effectively inhibits viral attachment (EC(50) is 5. 73 uM), viral entry (EC(50) is 4. 32 uM) and viral proliferation after infection (EC(50) is 8. 41 uM).  Morever, it enters mammalian tested cells (Vero) and reduces the intracellular infectivity.
What are the official names of this protein?
Peptide Hp1239.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: ISPF_ECOLU
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: COX2_DROTO
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNSYVNRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNNIEFDSYMIPTNELANDGFRLLDVDNRIILPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNYFIKWISNSVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SECA_METPP
Sequence: MLPKLLTSIFGSRNERLLKQYRRVVDQINALEPQFEQLGDDELRAKTEAFKQRVADGETLDQLLPEAFAVVREGSKRALKMRHFDVQLIGGMTLHNGKIGEMRTGEGKTLMATLPVYLNALAGKGVHVVTVNDYLARRDAEWMGRLYNFLGLTVGVNGPQMTREAKQAAYAADVTYGTNNEFGFDYLRDNMVTEVADRVQRSLNFAIVDEVDSILIDEARTPLIISGQAEDQTELYLRINAVAPLLKKQIGEADPRTGEGVIEAGDFTADEKTHQVVLTEAGHEHAEALLAQAGLLVEGASLYDAANITLMHHLYAALRARHLYHRDQHYVVQNGEVVIVDEFTGRLMTGRRWSDGLHQAVEAKEGVPIQAENQTLASITFQNYFRMYGKLAGMTGTADTEAYEFQEIYGLETVVIPPNKPTQRRDELDLVYKTSRERYEAVVKDIQDCYERGQPVLVGTTSIENSELISKLLEKYKLPHEVLNAKQHAREAEIIAQAGRPKAVTIATNMAGRGTDIVLGGNVEKQVQFIEADDAIPADDKLRRIQQLKDEWAGLHEQVKAAGGLRIVATERHESRRIDNQLRGRSGRQGDPGASRFYLSLEDPLMRIFAGDRVKAIMERLKMPDGEAIEAGIVSRSIEGAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNDILESKELGAQIAHLRRGAMTDVVRTFVPVESVEEQWDIPGLEKVLRDEWQLDVPIAAQVDKSDAITDEDLVEMVAKTADETYAGKVALVGEEQFSGFERAVLLQSIDTHWREHLAALDYLRQGIHLRGYAQKNPKQEYKREAFELFSTLLDTVKMDVTRLLMTVRIRSTEEVTQAAEALEEKAEAISNLTYTHPTEDGGVAVEADPATEVANRMAEVPRAGRNDPCPCGSGKKYKQCHGRLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: BTUB_VIBPA
Sequence: MKKSALAITLASLLSPVSYLQAQEISVDETIVVTANRFKQIDGAVLAQTVTVTKEDIRRQQADSLFDVFRTLPSIEVAQYGGRGQSASIFVRGGSATQVLVLVDGVRMPRAIMGGIDFNQFPINSIERIDYIRGARASIYGSEAISGVINIITRASIDDDASRVSAGYGSNNHKKGTFAVSKPVGEGKHIKGVLGYEKTDGFNVKPLPGLNDGDEHGFETLNLKLGYQQNFSDNFSGYVGFSTYSNEYDYDNSSYGNPGWGTVDKHEKKTGEVEYVGADLSLEYSKDVYTSELKLAYGQQDNYDLKSGQSKSTGDHVAIEQFNAIWLNSYSINDELSIGGGLDYRNEKLAKGYLAPSDWGPAKDYNPEKNPRTNIGISAIAQYALNAWTFEASVRNDENNQFGNNTTWQTAAGWKVYEGYELTLSHGTAFRAPSFVDLYYPGYEMPNLKPEESKNTELSLSGVASIVDWTVTGYYNQIENMLIWKGAGMQNIGEAEIKGIELEVKLDTDIVSHEFYLDYKDPVDKSGAEDTQLAYRSKRGAKWNAYATFDQWTLGSQYLYQGERFNGSTRLPSYSLWNFTASYAVNSSWDINAKLSNAFDKNYEMYSGYATPGRQYFVSADYRF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.