PharMolix/UniProtQA huggingface dataset:
Protein: MNMC_PASMU
Sequence: MHKVQFADVHFNAENTPVSAQFDDVYFSNQDGLAESHYIFQEGNQLWQRWQQTSEAHFVIAETGFGTGLNFFAVTQRFREFRLTYPDAPLKRLFFISFEKYPLPLAQLKRAHQAYPEFQSLAQQLQQSWLEPIVGCYRFHFAETTLDLWFGDMAENLPQLGDYMCNKIDAWFLDGFAPSKNPQMWQDTLYQHMYRYTKTQGTFSTFTAASAVRKGLIHAGFTVTKRKGYGKKRECLQGVKAQQQPADIHAPWALVQPAELTENADIALIGGGIASVFSALSLLERGAKVTVYCEDNSLAANASGNKQGAFYPQLSDDDLRYIRFYIHAFAYGKQRFNWAIEQGITFEHDFCGVALCAYDAKSAVKLAKISALQLPPSLYQPLSQQALSEQVGLPLPCDGGFIAQGAWLSPQQFVQNTFDFLATRGVIIKTQQKITALERQTTHWLLTTEQGDSFKHQVVVLANGHKLTQFRQTEHLPVYPVRGQVSEIATSTELSKLKAVICYDGYLTPKAASQTHCLGASHLRDNAERAFSLQEQQENQQKIQTNLASVDWVNEVDTRNNQARIGIRCSVRDRIPMLGNVPDFEQQLSDYHNLYNLRRRKHAIKHAALHPNLFLIGALGSRGLTSAPLLAETLASLIYHEPLPLSEDILHQLNANRSWIRKLLKGSQVKQG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATE_METST
Sequence: MSVGADKIISNIKADAQAKADEIISKAKAESEKIIADGEAKAQIEKEQILDSANKQADMKYQQIISEAKVNSRRKELEAREELIEKAFRIASEKIEKLASENSANYVESLKVMIKDASIQVGSTQLEILVREDDVENVKSMIDEVSEYVTKETGNETSFVIGEPIDIIGGAVVKTVDGDVEVKNTIEARMLRYRKHLRSEVAKKLFR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: RFCS_METKA
Sequence: MAEHELRVLEIPWVEKYRPKRLDDIVDQEHVVERLKAYVNRGDMPNLLFAGPPGTGKTTAALCLARELFGEHWRDNFLELNASVSADTPILVRRGGEVLRVTFEDLDSWYFGDRGGEYVDVSDLEVLTVDRNFRVTWARVSKLIRHRARKILRVHLEDGTIELTGNHAVMVLDEGGLRAVKASEIEEGSFLLSFVAELDEQPTDGGTVVTSVGSGSRVSDTTYELPVEVRVELLRELADDGVIEASEDVSVDLAWLARISGVESRVTDDGVELVWETRTGDLLPADPVLKLVERLESDLVDDLESWVFDGRVSKEAVRKVLSSVDAKNLRGDARRAYRMLRTLVRSDVHAVKVEDLDVMDYDGYVYDVSVPGNEMFFAGEVPVLLHNSDERGIDVIRTKVKNFARTRPMGGARFKIIFLDEADNLTRDSQQALRRIMEMYSDACRFILAANYSSAIIDPIQSRCVVFKFTKLPESAIKERLRKIAESEGVEITEDALDAIVYVSEGDMRRAINVLQAAAALGREIDEDTVFQIAATARPEEVREMIHHAWNGDFERARELLHELLTRYGMSGEDVVRQVHREIFDMDEIPEEAIPELVNAVGDFEYRLIRGSDERIQLEALLARIHALGNEYSGG
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: NRDI_MYCSK
Sequence: MGNIVYFSSVSENTHRFVEKLELPATRIPILGRIQDPDFVREPYVLVLPTYGGGHANGPDPDAGGYVPKQVIAFLNNEHNRSLIRGVIAAGNTNFGAEFGYAGDVVSRKCGVPYLYRFELMGTTDDVLAVRAGLENFWKEQTCHPPSQLQSL
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: CYVUC_VIOPU
Sequence: GIIPCGESCVFIPCITSIVGCSCKSKVCYKN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide vpub-C.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: RAB42_MOUSE
Sequence: MEAAGCSYQFRIALLGDAGVGKTSLLRCYVAGARGAAEPDPEPTVGVEFYSRALQLPAGLRVKLQLWDTAGQECFRCITRSFYRNMVGVLLVFDVTNRESFEHIQAWHQEVVSTQGPDKVVFLLVGHKCDLNTRCVSSQEAEELAASLGMGFMETSAKSNCNVDLAFDTVTSAIEQALQQGDIKLDKDWAGVRLLHRSPNPRSSSRKQDSGTCQC
What are the official names of this protein?
Ras-related protein Rab-42.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: RL7_GLAP5
Sequence: MSLTNEQIIEAIASKSVSEIVELITAMEEKFGVSAAAAAVAVAAGPAEAAEEKTEFDVILADAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGISKGEAEALKKELEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RL32_OCEIH
Sequence: MAVPKRRTSKKVKNQRRTHKKLHVPGMVECSNCGELTKPHRVCKSCGHYDGKEVVNG
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: SECA_KARMG
Sequence: MIYINNIINFFFKKKNKIEIKKLKIVLNKINFFLGKLKLYSNDELRNKTFSFKRRIKKKTKSLYEKKFGLQKKLIYKNFISIEEMHENKLILSEIEEIKNNIYKEEEKILLELLPEAFAVVKETAKRFKENKQIIVTSNELDYRLSKSRSYLELKGGKTIWNNKWSYMGKELIWNMIHYDVQLMGGIVLHQGKIAEMYTGEGKTLVATLPIYLNALTGKGVHVVTVNEYLAKRDSEWMAPIMEFHGLTVDCIDLYKKNSYLRRKAYEADVTYGTNNEFVFDYLRDNMVYSCKNLIQRELNYAIIDEIDSVLIDEARTPLIISAGVSGQVNSNYYLLKDKVKKLFKKQLYFLNKIFNLSREQIISGNEKEGGLNLFKVYRGLPKYKPLIKFLGEKKNRKILEDTEYYFMQDNNKNMFIVDSDLFFVINEKNNTVEFSEKGINFISEEMNDPNFFILPDIHKKFIDLESLKISKTQKEIIKNELITNYYNKSDKIHTVNQLIKAYTLFYKNIHYLVIDNKVKIVDEQTGRIIEEKRYSDGLHQALEAKENVNIENSSQPLATITLQNYFRMYKKLSGMTGTAETEYEEFIKIYNLDVVIIPTNKPIIRKNYEDILFRTKKEKYNAIINEIIFLSKNEKRPVLVGTTSVEISELISRSLNIRNINNNVLNAKHHKKEAYIIEEAGKSGIVTIATNMAGRGTDIKISDEVKKLGGLAIIGTERHDSRRIDRQLIGRTGRQGDPGSSKFYLSLEDDLMRIFGLDRISTILDKLGHKKGEYLTGGLISNSIQLAQKKIEENNFSIRKRLLEYDSVINEQRKFIYAFRRNALNINLSSYIIYNLVDKIDSKQRFEEFEEELFNIFKIKNLISYNTFLKKKDIKKKLYYKINKYYNIRKNKMLSKLIYIKSYKKFCCKNKKIKSYFTYSINDRIIRLFLKEENNLYKIINNLEKKIILYFIDDKWKTHIHNMEDLRKYSQYSVYEQKDPIIIYKIKAFKLFNNFFYNLNKLSLTFFFNCKINNSLI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
Protein: KDPC_CERSK
Sequence: MMTHLRPALASLLALSLLTGVAYPLALTGIAAVIAPDRAAGSLILREGQVVGSALIGQGFEGPGYLHPRPSASDWNAAGTSASNLGPTSAALLAQVQERQAAYEAQNGASAPVDAVTASGSGLDPHVSPANARAQAGRIARARGLEEAAVRRLIEAHVEPPLLGLWGQARVNVLAVNLALDAAGA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: EX1_ECOLI
Sequence: MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENDDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKALWQYAEEIV
What is the function of this protein?
Degrades single-stranded DNA (ssDNA) in a highly processive manner (PubMed:23609540).  Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase (PubMed:1329027).
What are the official names of this protein?
Exodeoxyribonuclease I, ExoI, Exonuclease I, DNA deoxyribophosphodiesterase, dRPase.
Protein: ZN667_RAT
Sequence: MPAARGKSKSKAPVTFGDLAIYFSQEEWEWLSPNQKDLYEDVMLENYHNLVSVGLACRRPNIIALLEKGKAPWMVEPSRKRRGPELGSKDETKKLPPSQCNKSGPSICKKPDSSQQKVPTEKAKHNKNAVPRKNKKGHSGKKSLKCNSCGKTFFRSLSLKLHQGFHTGERSYECSTCGQVFRQILSLILHQRVHTQNKSYECDKCGDIFNKKLTLMIHRRSHNGKENFHHEKTSDSCPSLSPHHNNHAIDSIHQCRKCGKVFSRMSSLLLHKKIHNRKRIQKYSACGRGFKKKPVLVHKRICIGKKTHENKALIQSLRQRTYQSENPFTCRKCRKSFSRISALMLHQRAHTSGNPYKCDKCQKDFGRLSTLILHLRIHSGEKQFKCNKCEKVCNRLSSFIQHKKIHKRKKKLIECKECGKMFGGMKNLKVHLNIHSEEKPFKCNKCSKVFGRQSFLSEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHSEDRPYECDLCGKAFSQSAHLAQHERIHTGEKPYACKICKKSFTQRISLILHERSHTGEKPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQSIHSEEMS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 667, Myocardial ischemic preconditioning up-regulated protein 1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MYG_OCHCU
Sequence: MGLSDGEWQLVLTVWGKVEADLAGHGQEVLIRLFKNHPETLEKFDKFKNLKSEDEMKGSDDLKKHGNTVLSALGGILKKKGQHEAELKPLAQSHATKHKIPVKYLEFISEAIIQVLQSKHPGDFGADAQGAMSKALELFRNDMAAKYKELGFHG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: AROE_ENT38
Sequence: MEKYAVFGNPIAHSKSPFIHQQFAQQLHIDYSYDRVLAPVDDFLATLNAFFCEGARGANVTVPFKEDAFERADELTERASLAGAVNTLKRLDDGRLLGDNTDGIGLLSDLERLSFIKPGSRVLLIGAGGASRGVLLPLLSLDCAVTITNRTYSRAKDLATLFAHTGSISAVAMEDLEGHEFDLIINATSSGIAGDVPAIPASLVKAHVYFYDMFYQKGSTPFLSWCEDHGAKHMSDGLGMLVGQAAHAVLLWHGVLPAVEPVIEKLKQELLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: DAAA_STAAM
Sequence: MEKIFLNGEFVSPSEAKVSYNDRGYVFGDGIYEYIRVYNGKLFTVTEHYERFLRSANEIGLDLNYSVEELIELSRKLVDMNQIETGAIYIQATRGVAERNHSFPTPEVEPAIVAYTKSYDRPYDHLENGVNGVTVEDIRWLRCDIKSLNLLGNVLAKEYAVKYNAVEAIQHRGETVTEGSSSNAYAIKDGVIYTHPINNYILNGITRIVIKKIAEDYNIPFKEETFTVDFLKNADEVIVSSTSAEVTPVIKLDGEPINDGKVGPITRQLQEGFEKYIESHSI
What is the function of this protein?
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine.  The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.  The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism.  This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components (By similarity).
What are the official names of this protein?
D-alanine aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, DAAT, D-aspartate aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: SYA_SHESW
Sequence: MYQTTAELRSAFLEFFRSHGHQVVDSSSLVPGNDPTLLFTNAGMNQFKDVFLGMDKRNYTRATTAQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEEAICFGWSFLTETLKLPKERLCVTIYQTDDEAFEIWNKKIGVAAENIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGRPGSPEEDGDRFIEIWNIVFMQYNRHISGEMLPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFRALIAKAAEIIGVTDLSNKSLRVIADHIRSCAFLVADGVMPSNEGRGYVLRRIIRRAVRHGNKLGATEAFFYKLVPTLIDVMGDAAKGLAETQVIVEKALKAEEEQFARTLERGLGILDAALSELTGDTLDGETVFKLYDTYGFPMDLTADVCRERNIIVDEAGFEAAMAEQRSRAQAAGNFGADYNAALKIDAETAFCGYTELVGQAKVTAIYQNGESVTAIKAGDEAVLVLDVTPFYAESGGQVGDKGQLVANGIEFTVNDTQKYGQATGHQGVLVAGSLSIGQMVEAKVDKKLRHRTQLNHSVTHLLHAALRQVLGTHVTQKGSLVDPERLRFDFSHFEAVKPAELKKVEELVNTQIRRNHELKVAEMAIDEAKEKGAMALFGEKYDAQVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEGGIAAGVRRIEAVTGAAAMAYVAQQQAELEEAAALLKGDTHSVVAKLKAQLDKMKQLEKDMAQLKDKLAAAASADLVGDAVVVNGVNVLIKKLDGVEAGSLRGLQDELKQKLKSAIIVLGTAQEGKVNLIAGVSNDLVGKVKAGELVAMVAAQVGGKGGGRPDMAQAGGSQPENLDAALAQVLPWITERLA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23A_HUMAN
Sequence: MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547).  Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547).  May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).
What are the official names of this protein?
60S ribosomal protein L23a, Large ribosomal subunit protein uL23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.
Protein: SECA_STRR6
Sequence: MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAKTVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKSPMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEARTPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLENLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGLHQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIPIPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKLVAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSEEAIESRMLTRQVEAAQKRVEGNNHDTRKQVLQYDDVMREQREIIYAQRYDVITADRDLAPEIQAMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAIKEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRNIAAHQASMPEDLDLNQIGRNELCPCGSGKKFKNCHGKRQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: CYSK2_MYCTU
Sequence: MRSRQTRDRYRLLPEGYQVTPGRNRHPGTMVGNTPVLWIPELSGTSDPDRGFWAKLEGFNPGGMKDRPALYMVECARARGDIAPGAAIVESTGGTLGLGLALAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARKDRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLALELVAQLGRIDVLVCSVGTGGHSAGVARVLREFNPDMRLIGVDTIGSTIFGQPASNRLMRGLGSSIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAGWAARNLPADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQPPTEPDEIASPLDAVVTRWTRSTTVIDPTQVVS
What is the function of this protein?
Catalyzes the synthesis of S-sulfocysteine, utilizing O-phosphoserine (OPS) and thiosulfate as substrates.  To a lesser extent, can also use sulfide as donor substrate, producing L-cysteine.  CysK2 thus provides a third metabolic route to cysteine, either directly using sulfide as donor or indirectly via S-sulfocysteine.  S-sulfocysteine might also act as a signaling molecule triggering additional responses in redox defense in the pathogen upon exposure to reactive oxygen species during intracellular survival or dormancy.  Cannot utilize thiocarboxylated CysO as a sulfur donor and O-acetylserine (OAS) as acceptor substrate.
What are the official names of this protein?
S-sulfocysteine synthase, O-phospho-L-serine-dependent S-sulfocysteine synthase, OPS-dependent S-sulfocysteine synthase, O-phosphoserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: ISPH_PSEE4
Sequence: MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRNRGAVFVEELDQVPDDVIVIFSAHGVSQAVRQEAAGRGLKVFDATCPLVTKVHIEVAKYSRDGRECILIGHAGHPEVEGTMGQYDASNGGSIYLVEDEKDVAALQVRNPDHLAFVTQTTLSMDDTSRVIDALRERFPNIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMSTPAYLIDGAEDLQRSWFDGAQRIGITAGASAPEVLVRGVIDQLKAWGATGAEELDGREENITFSMPKELRVRSLI
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: SSN8_ASPTN
Sequence: MAANYWVSTQRRHWLFTRERLADIREGFKERDKVAHSQFPLPDQRLLNIYFSQQLIKLGKRTTTRQQALATAQVYIKRFYTKNDIRHTNPYLVITTAFYLACKMEECPQHIRFVVAEARSFWPEFIAPDVSKLGECEFALISEMNSQLIVHHPYRTLSELTPELQLTSDEVALAWSVINDHYLTDLPLLYPPHVIAVMAIIVAVVFKPSQTSFHGSAGPALAGAMRDGGVNLLAALGDKNGNGPPRIQKLVGWLAESEVDIKAVIECTQELVSLYEIWEQYSEKHCKELLGRMVKSKNLDK
What is the function of this protein?
Component of the srb8-11 complex.  The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
RNA polymerase II holoenzyme cyclin-like subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ELMM1_STROV
Sequence: MDSPQVARTLVDSAGGTAAHTREAIRQIGVPETAAFLADELAGRTETVTIRHAAEVQFVFDDRYAPDAADPVPWTFRVGPEGVTHRAGALPDPGAVVTQDLTELARSLYGPAADRSDATRTVWWRDHDDPRVYFDPPPVFPAVERLLAAADGRDVPGLAGLALRHGSDKWGIHTYTAAYEQHFAPFRDRAVTVVEIGVGGYDDPAAGGGSLRMWKRYFRRGLVYGVDIADKSRHREPRVHTVVADQSDPASLRDLADAIGPIDIVIDDGSHISAHVVTAFSTLFPRLNPGGLYVVEDLQTSYWPAFQGAYDDDTRTSVGFLKRLVDGLHHAEYPSRAGRPAQPTDRTVGSLHFHPNLAFVEKRANSGHGGISRLREAT
What is the function of this protein?
O-methyltransferase involved in the biosynthesis of the permethylated L-rhamnose moiety of elloramycin, an antitumor polyketide.  Mediates the methylation of the hydroxy groups at the 2'-position after the sugar moiety has been attached to the aglycon.
What are the official names of this protein?
8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase, O-methyltransferase I.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase OleY/MycE family.
Protein: HPLN3_MOUSE
Sequence: MSLLFLVLLSPFPCVLGLPFYNGFYYSNDLSGRTLGNGYGEGLFNGVKLVVETTEESLFSHQGASVTLPCHYHYEPALASPRHVRVKWWKLSENGAPEQDVLVVIGQRHRSFGDYQGRVQLRQDKQQEVSLELRDLRLEDSGRYRCEVIDGLEDESGLVELELRGVVFPYQSREGRYQLNFHEAQQACQEQGAMVATFEQLFRAWEEGLDWCNAGWLQDASVQYPIVLPRQPCGGLGLAPGVRSYGQRHHRLHRYDVFCFAAALKGRVYYLENPKKLTLLEAREACQEDGAQISTVGQLFAAWKFRGLDRCDAGWLADGSARYPIVHPRLNCGPPEPGVRTFGFPDPHTRYGVYCYVQH
What is the function of this protein?
May function in hyaluronic acid binding.
What are the official names of this protein?
Hyaluronan and proteoglycan link protein 3.
What is the protein family that this protein belongs to?
Belongs to the HAPLN family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RNZ_AERPE
Sequence: MGRIDITILGSGSAVPSLHRWHPSILVKDWMGNTVLLDAGEGVQIRLRKVGVSPSSIDVLAITHPHGDHINGVAGLLMTMSLQSRRKPLTIISTSESLEFISETLEATRENLGFEVMLVDARESGVLDVGRPSGDRLTIEWERACHNIESLAFKLVWTLRPRIDARILERLDLKAGPWIRELIEKGRAHVEGRIVTLKDISASGERKYSVAYTGDTSPCTRVAKFLHGSDILIHDSTLDSSLAREAAERGHSTSLDAARNALTSGAKLLILFHVSSRYSGYEARLLLKEARRVFPNTVLSWDGMKLSITI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: COAX_ACIB3
Sequence: MKSLWLDIGNTRLKYWITENQQIIEHAAELHLQSPADLLLGLIQHFKHQGLHRIGISSVLDTENNQRIQQILKWLEIPVVFAKVHAEYAGLQCGYEVPSQLGIDRWLQVLAVAEEKENYCIIGCGTALTIDLTKGKQHLGGYILPNLYLQRDALIQNTKGIKIPDSAFDNLNPGNNTVDAVHHGILLGLISTIESIMQQSPKKLLLTGGDAPLFAKFLQKYQPTVETDLLLKGLQQYIAHYPKD
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQB_METC4
Sequence: MHVVILGSAAGGGVPQWNCRCSICSLAWAGDSRVRPRTQSSIAVSPDGERWLLLNASPDIRQQIQANPQMHPREGLRHSPIHAVLLTNGDVDHVAGLLTLREGQPFSLYATPGILASVSDNRVFDVMAAEVVKRQTIALNETFEPVPGLSVTLFSVPGKVPLWLEDASMEIGAETETTVGTMIEAGGKRLAYIPGCAGVTEDLKARIAGADALLFDGTVLEDDDMIRAGVGTKTGWRMGHIQMNGETGSIASLADVEIGRRVFVHINNTNPVLIEDSSERASVEARGWTVAHDGLTLDL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.