PharMolix/UniProtQA huggingface dataset:
Protein: FTHS_LACLA
Sequence: MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVTSINPTPAGEGKSTVTVGLADAFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRRIIWKRVVDLNDRALRHVTVGLGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGVQGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAGFGADLGGEKFLDIKTRQLGKQPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANLERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALGVPVSLTQVFAKGGEGGLDLAEKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWNDLPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPASLKMDVTDDGKISGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ELO1_CAEEL
Sequence: MAQHPLVQRLLDVKFDTKRFVAIATHGPKNFPDAEGRKFFADHFDVTIQASILYMVVVFGTKWFMRNRQPFQLTIPLNIWNFILAAFSIAGAVKMTPEFFGTIANKGIVASYCKVFDFTKGENGYWVWLFMASKLFELVDTIFLVLRKRPLMFLHWYHHILTMIYAWYSHPLTPGFNRYGIYLNFVVHAFMYSYYFLRSMKIRVPGFIAQAITSLQIVQFIISCAVLAHLGYLMHFTNANCDFEPSVFKLAVFMDTTYLALFVNFFLQSYVLRGGKDKYKAVPKKKNN
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids.  Condensing enzyme that catalyzes the elongation of monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Elongation of long chain fatty acids protein 1, ELO-1, Long-chain 3-oxoacyl-CoA synthase 1, CEELO1.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NU6C_LEMMI
Sequence: MDLTGPIHDILVVFLGLVLILGGLGVVLFTNPIYSAFSLGLVLICVSLFYILLNSYFVAAAQLLIYVGAINVLILFAVMFMKGSEYSNDLNLWTVGDGVTSLVCTSILFLLISTISDTSWYGIIWTTKANHIIEQDLISNVQQIGIHLSTDFFLPFELISIILLVALIGAISMARQN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ARTA_ECOLI
Sequence: MEKRSFKEKLEIIRNIIRESLLGNAAIIALIYAASHSLPVNAFPDYLVISLLSIAAGIVVLWLFSIIYIYFCELFRSHWIAVWFIIWSSVINLIILYGFYDRFI
What are the official names of this protein?
Protein ArtA.
Protein: MYLK3_MOUSE
Sequence: MSGVSEEDPEGLAPQGLPALGGACLATMDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLEQDLHRLEASRELSLAGSGSTPPTTAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAITLVGSTFQNSKVADFIMQGTVPGRKGSLADGPEENKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKGADLTQAGASLRQGVEVLGPGQVPLPTEAESRLPETASENTGATLELSVAIDRISEVLTSLKMSQGGGQETSSSKPDCWLSEEAMRLSSGPLPQPLGPLTPDSDIHSGDALPRIPINMQEMATPGELLETQSGSPIGSAEAPGLGTVLEDQIPKGARPFPPLPKRSSNNGGMSAEEEIGSGAEPMRGPSLATRDWRDETVGTTDLQQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISAGYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQLSHVNLIQLYDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLSHLPAKASGSNVRLRSQQLLQKYMAQSKWKKHFHVVTAVNRLRKFPTCP
What is the function of this protein?
Kinase that phosphorylates MYL2 in vitro (PubMed:18202317, PubMed:17885681).  Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317).  Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).
What are the official names of this protein?
Myosin light chain kinase 3, Cardiac MyBP-C-associated Ca/CaM kinase, Cardiac MLCK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_NOVAD
Sequence: MKISGVDIRPGNILEYEKGIWKVAKTQHTQPGKGGAFMQVEMKNLIDGRKTNVRFRSADTVERVRLDTKDFQFLYAEGDDLVFMDVETYDQITLPSDLLGDAAAFLQDGMTVLLEMYDERPISVQLPEQVEATIVEADAVVKGQTASSSYKPAILDNGVRVMVPPHIESGTRIVVDVYERSYVGKAN
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2A7_ARATH
Sequence: MESTGKVKKAFGGRKPPGAPKTKSVSKSMKAGLQFPVGRITRFLKKGRYAQRLGGGAPVYMAAVLEYLAAEVLELAGNAARDNKKSRIIPRHLLLAIRNDEELGKLLSGVTIAHGGVLPNINSVLLPKKSATKPAEEKATKSPVKSPKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2A.7, HTA6.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FIXX_SINFN
Sequence: MTASVVRIEDKLYQNRYLVDAGRPHIKVRQHQSPSPNLLALTVVCPAKCYEVNEDGQVEVIADGCMECGTCRVLCEESGDIDWSYPRGGFGVLFKFG
What is the function of this protein?
Could be a 3Fe-4S cluster-containing protein.
What are the official names of this protein?
Ferredoxin-like protein.
What is the protein family that this protein belongs to?
To ferredoxins from P.putida and C.tartarivorum, ferredoxin I from A.vinelandii, ferredoxin II from D.desulfuricans.
Protein: CCL25_PIG
Sequence: MRPWLLACLVACFVGAWAPAIHAQGAFEDCCLAYHSHIKWRLLRRAHSYQRQDVSGSCNLPAVIFFFPQKDKMVCGKPGAKWVQFGMKILDNRNKKDSKPHHSGRRFFQGPQSGVRKLSSGTSRPLLLKFSGPTRSSKRKASLLTTAIPGP
What is the function of this protein?
Potentially involved in T-cell development.  Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils.  Binds to CCR9.  Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
What are the official names of this protein?
C-C motif chemokine 25, Chemokine ligand 25, Small-inducible cytokine A25.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURE_PHOV8
Sequence: MKLEKIIKGITVNEIIGDASQEISGINMDSRLIEPGHIFVAVKGTQTDGHTYIQKAIEKGARTVVCENLPETLIENVTYIKVNDTEDVVGKLATTFYGDPTSKLELVGVTGTNGKTTIATLLYNMFRKFGYKTGLISTVCNYIDEEAIPTDHTTPDPITLNKLLGRMADEGCKYAFMEVSSHSVAQKRIGGLKFAGGIFTNLTRDHLDYHKTVENYLKAKKAFFDGLPKTAFALTNLDDKNGLVMTQNTKAKVHTYSLRSLSDFKGKVLEDGFEGMLLDINNVEVNVQFIGRFNASNLLAVYGAACLLGKKTEEVLLALSTLRPVAGRFDSLRSPKGYTAIVDYAHTPDALENVLNAIHEVLNGKGHVITVVGAGGNRDKGKRPLMAQEAVKQSDKVIITSDNPRFEEPQEIINDMLAGLTKEDMRKVISIADRKEAIRTACMLAQAKDVILVAGKGHENYQEIKGIKHHFDDKEVLRDIFANE
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDA_LACP3
Sequence: MAIQLPGFTMKNPLMPASGTFGFGEGYAKEYDLNLLGALVTKSTTLAPRIGNQGTIFADGPDSTLNAVGLKNPGSDVVLHEKLPWLATQYPDLPIIASIAGVDVAEYAAVAKKLSAAPNVKALEVNISCPNVKQGGMAFGTDPEVAAAVTRAVKAASSVPIFVKLTPNVTDITAIAKAVEQAGADGLSLINTFVGMRLDIATGKPLLDNVTGGVSGPALLPMALHMVYQVAHAVRVPLIGMGGISSGHDAAEMLAAGATALAVGSANYYQKRAIPKIAAELAAIQEGQTVL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YA39_SCHPO
Sequence: MTRTRVQKMIPKTIEYQKMISGQPYKAYDEELTQARCNAKKLMRRFNDTMGDLENVGPAELIKRRAELLAEVFVFDESSAPEIEPPMAFDYGFNVHFGKKFFANYNCTFLDVAIITIGNNVMLGPNVQLCTATHPLDFKARNSGIEFGLPINIQDNVWIGMGVIVLPGVTIGEGSVIGAGAVVTKDIPPNTLAVGSPAKPIRKIENE
What are the official names of this protein?
Putative acetyltransferase C18B11.09c.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: GREA_RHOP5
Sequence: MEKVPMTANGYAALQVELKQRQTVDRPRIIEHIAEARSHGDLSENAEYHAAKEEQSHNEGRIADLEDKLARADVIDITKLSGDTIMFGATVTLVDEDTEKKAVWQIVGEPEADAKKGRISITSPLARALIGKKKGASVEVMAPGGAKAYEITKVEWREPS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: CYSH_XANC8
Sequence: MTALPATSIAAPSLDDLDALNAHLETLRADERVAWALQHGPQQAALSSSFGAQSAVTLHLLTQQRPDIPVILIDTGYLFPETYRFADALTERLSLNLQVYRPLVSRAWMEARHGRLWEQGMVGIDQYNNLRKVEPMRRALDELNVGTWFTGLRRSQSGGRAQTPIVQKRGDRYKISPIADWTDRDVWQYLQAHALPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFFGLKRECGIHEDI
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH18_DROSU
Sequence: MMKFMCIFICAVAAVSASGYGGRRPSYGSAPIGAYAYQVQPALTVKAIIPSYGGQRGYGHNQGGYEAAPIASAYGNADIGNQYGPVSGSRYGGAPPVDREAIALAKLALAAPSAGGPLVWREAPRRVQHAYGPSNYGAPQQRYARAEEAQGASAAAASSSVAGVAKKGYRKSSY
What is the function of this protein?
Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
What are the official names of this protein?
Chorion protein S18.
What is the protein family that this protein belongs to?
Belongs to the chorion protein S15/S18 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR5_METVS
Sequence: MVTYKDAGVDIYEEDRIIRALISKINFEREDAIKPADLKGHYAGAIEFGDYYLVLCTDGVGSKMVVAEMANNFETVPIDMIAMNVNDAICIGAEPVALVDYMAVEEITENIAEQIGKGLNEGIKESNINLIGGETASLPNMIKGIDLAGTVLAVVKKSEIISGQTVKKGDVIVGLRSSGIHSNGLSLARKVFFEISNLNVNSKLSYGKTVADELLTPTRIYVKPVLDMIKKADVKGLAHITGGGFRKLKRLNKEVCYKIDNLPEIPPIFKEIQTLGNVADEEMFKTFNMGIGFCVIVSKENAEKIIEISNQYKIPAFVIGEIEDNIEIDGEFKKETVLVEYNGKKMIME
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_FRATF
Sequence: MNIRPLQDRVLVRRAEEEKKSAGGIILTGNAQEKPSQGEVVAVGNGKKLDNGTTLPMDVKVGDKVLFGKYSGSEVKVGDETLLMMREEDIMGIIA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_BACHK
Sequence: MSFASETKKELTNLEMKECCEKAELSALLRMNGSLSFSNRRLSIDIQTENAAIARRIYTLLKKGYDVTVELLVRKKMRLKKNNVYIVRLVEKSREILADLHIVRDDFSFIRNISQELIEKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDAICELMNGFDLNSKTLERRKGYITYLKEAEKITEFLNIIGAHNALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQIENIRYIDETVGLDILPDKLREIAQLRRDYQDVTLKELGEMVSGGKISKSGINHRLRKIDDIAEKLRAGETVAKK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: PEX5_DEBHA
Sequence: MSFVGGGADCSANSNAIAQFNKHTQQDRSLQRQAANQQGIVQNGQGFKKDSMMNERERQNMDQFMNNGPSQSNFQFQPMRHELNMIQQNHKQPNVQNNWTNEFQTNSPSPVQRNTPLAKTGSPANAQWATEFQQPMDQTFNQSNQQQFNNMPNMRMGGYRPMMGMSMMGGGMHQQQNQMQHQEQNQDHQVDWDNQFKEIEQLTNETKDAEAEQVKGEEEPEIVIDDKYQATFQEVWDSLNSEEVENDFINQQYEEFKNTQRDSMPADMAQWEKDFAKYASTRAHFGDYQFEDNQHNQFLDLPKESDPYEIGLQLMENGAKLSEAALAFEAAIQRNEGHINAWLKLGEVQTQNEKEIAGISALEKCLELHPENSEALMTLAISYINEGYDNAAFATLERWISTKYPQVADQARQQNPAIDDEDRFSLNKRVTELFLNAAQLSPNSANMDPDVQMGLGVLFYANEDFDKTIDCFKAALSIKPDDAVLWNRLGASLANSNRSEEAVDAYFKALELKPTFVRARYNLGVSCINIGCYKEAAEHLLSGLSMHQVEGVQTDASSTLNHNQSTSLTETLKRAFIALDRRDLLEKVKPDMDINQFRGEFSF
What is the function of this protein?
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).  Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins.  PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
What are the official names of this protein?
Peroxisomal targeting signal receptor, PTS1 receptor, PTS1R, Peroxin-5.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal targeting signal receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane (By similarity).
Protein: FABH_AGRRK
Sequence: MIRSVVRGFGAALPKRVMTNRDMEQVVDTSDDWIVQRTGIRQRYIAGEGETTASLGEQAARAALANAGLTADDLDMIIVATSTPDNTFPATAVNIQNRLGMHHGFAFDVQAVCSGFVYAVTTADAYIRGGVAKRVLVIGAETFSRILDWTDRTTCVLFGDGAGALILEAGEGTGANTDRGVLTASLRSDGAHKDKLYVDGGPSSTGTVGVLHMAGREVFKHAVGMITDVIEATFKAADVTADDLDWLVPHQANRRIIDGSAKKLGIAPEKVVVTVDLHGNTSAASIPLALAVAAGDGRIKRGDLVMLEAMGGGFTWGAVLLRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I93A0
Sequence: MNPNQKIITIGSVSLTIATICFLMQIAILVTTVTLHFKQYECSSPPNNQVIPCQPTIIERNITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLNNRHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCVTGHDENATASFIYDGRLVDSIGSWSKNILRTQESECVCINGTCTVVMTDGSASERADTKILFIEEGKVVHISPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVSSYVCSGLVGDTPRKNDSSSSSYCQNPNNEKGSHGVKGWAFDDGNDVWMGRTISEELRSGYETFKVIGGWSTPNSKLQINRQVIVDSGNRSGYSGIFSVEGKSCINRCFYVELIRGRKQETKVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: TFB1M_XENLA
Sequence: MATPGALAKFRLPPLPTIGEIVKLFNLRAEKQLSQNFLLDLKLTDKIVRRAGNLQNAYVCEVGPGPGGITRSILNAGVEELLVVEKDTRFIPGLKMLNEASGGKVRTVHGDILTYRMDRAFPKHLIKSWDDEPPNVHIIGNLPFSVSTPLIIKWLEQVADRTGPFTYGRTQMTLTFQQEVAERLTASTKNKQRSRLSIMSQYLCNVKNCFTIPGRAFIPKPKVDVGVVHLTPFVQPKIEQPFKLVEKVVRCIFQFRRKYCHHGVSILFPEEIRIQLTEQMLRLADVDPTLRPTELTMTHFKKLCNVYREMCDQNPHLFSYNYREELRMKKLQGKSTEEEDDLLQ
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.  Also required for basal transcription of mitochondrial DNA.  Stimulates transcription independently of the methyltransferase activity (By similarity).
What are the official names of this protein?
Dimethyladenosine transferase 1, mitochondrial, Mitochondrial 12S rRNA dimethylase 1, Mitochondrial transcription factor B1, mtTFB1, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS13_PSYWF
Sequence: MARIAGVNIPDNKHAVISLTYIFGIGRTTAKKILDTVGIAPTTKISQLDDAQLDAIRAEVGNYMTEGDLRREVSMNIKRLVDLGCYRGIRHRRNLPVRGQNTKNNARTRKGPIRSIKR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RF1_ENDTX
Sequence: MFLEKLKLLNSIFEEVESKLSDLSVISNQEEYRELTKQHFYLRPLAEKYIRYSKLLNEIKDAEELQKSKDAEMKEIAFAEYNNLIEKRNQMENEIKVLLIPTDPNEDKNIIVEIRAGTGGNEAALFVGDLYGMYTRFAERNGWKYEVLGSNPTGLGGYKEVVFEINGGKVWRCFKFERGAHRVQRVPETEASGRVHTSAATVAVLPEAEEVDVEIKMEDLRIDTYRASGAGGQHINKTDSAIRITHLPTGLVVACQDERSQIKNRAKAFKVLRAKIYEQRILEHEMRLSSERKQQIGSGDRSEKIRTYNFPQNRITDHRIGYSVYNITEVMDGNLSELVNKLIKADIESKLKENNI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1D_HUMAN
Sequence: MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS
What is the function of this protein?
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5. 8S rRNA; this function may include MPHOSPH6.  Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA.  Can induce apoptosis in a p53/TP53 dependent manner.  May regulate the TRAX/TSN complex formation.  Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
What are the official names of this protein?
Nuclear nucleic acid-binding protein C1D, hC1D.
What is the protein family that this protein belongs to?
Belongs to the C1D family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738).
Protein: MAGBG_HUMAN
Sequence: MSQDQESPRCTHDQHLQTFSETQSLEVAQVSKALEKTLLSSSHPLVPGKLKEAPAAKAESPLEVPQSFCSSSIAVTTTSSSESDEASSNQEEEDSPSSSEDTSDPRNVPADALDQKVAFLVNFMLHKCQMKKPITKADMLKIIIKDDESHFSEILLRASEHLEMIFGLDVVEVDPTTHCYGLFIKLGLTYDGMLSGEKGVPKTGLLIIVLGVIFMKGNRATEEEVWEVLNLTGVYSGKKHFIFGEPRMLITKDFVKEKYLEYQQVANSDPARYEFLWGPRAKAETSKMKVLEFVAKVHGSYPHSFPSQYAEALKEEEERARARI
What are the official names of this protein?
Melanoma-associated antigen B16, MAGE-B16 antigen.