PharMolix/UniProtQA huggingface dataset:
Protein: TETX_BACT4
Sequence: MTMRIDTDKQMNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEINCPGFFQLCNGNRLMASHQGNLLFANPNNNGALHFGISFKTPDEWKNQTQVDFQNRNSVVDFLLKEFSDWDERYKELIHTTLSFVGLATRIFPLEKPWKSKRPLPITMIGDAAHLMPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEAQEESTQNEIEMFKPDFTFQQLLNV
What is the function of this protein?
An FAD-requiring monooxygenase active on tetracycline antibiotic derivatives, which leads to their inactivation (PubMed:15452119, PubMed:16128584).  Hydroxylates carbon 11a of oxytetracycline and tigecycline (PubMed:15452119, PubMed:26097034).  Acts on many tetracycline analogs (chlorotetracycline, demeclocycline, doxycycline, minocycline, oxytetracyclinee), probably by monooxygenization (PubMed:15452119, PubMed:16128584).  Tigecycline, a new generation tetracycline antibiotic, is rendered less effective against E. coli by this monooxygenation, is much weaker at inhibiting translation in vitro and binds Mg(2+) considerably less well (PubMed:16128584, PubMed:26097034).  Expression in E. coli BW25113 reduces its growth rate about 5%.  The reaction probably proceeds by FAD reduction by NADPH and, second, hydroxylation of antibiotic in a ping-pong mechanism (PubMed:23236139).  Degrades chlortetracycline, probably by monooxygenation (PubMed:15452119, PubMed:28481346).  Slowly oxidizes anhydrotetracycline, the final substrate in tetracycline biosynthesis (PubMed:26097034).
What are the official names of this protein?
Flavin-dependent monooxygenase, TetX monooxygenase, TetX, TetX2.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNPY4_MOUSE
Sequence: MCGLRFIMGPVRLEILLFILAAYGAWAEATKEEEDDTERLPSKCEVCKLLSMELQEALSRTGRSREVLELGQVLDTGKRKRHVPYSLSETRLEEALENLCERILDYNVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVVGDWYFHHQEQPLQHFLCERHVLPASETACLREAWTGKEKISDGQEEADDEEEEEEEEITKTSGNPKHDPEDL
What is the function of this protein?
Plays a role in the regulation of the cell surface expression of TLR4.
What are the official names of this protein?
Protein canopy homolog 4, Protein associated with Tlr4.
What is the protein family that this protein belongs to?
Belongs to the canopy family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEPA_DEIRA
Sequence: MTAGPTDPTPTSQIRNFSIIAHVDHGKSTLADRILEQLGAMGERDKRDQTLDTLELERERGITIKSTPIRLEYTRENGEGYVFNLIDTPGHVDFNYEVSRSLAACEGVLLLVDASQGVEAQTIVNAYLAIDNNLEIVPVINKIDLPAADPEGAARELEEVIGIPAEDAVRASGKTGIGIPEILEAVVERIPPPAGDPGAPLKALIFDSFFDAYQGVILFVRVLEGTMKAKDGVRLMNAGKNFEVDKVGTFSPGLVVGQELSAGMVGWVAAGIKDIQDAQVGDTLTGSDRQTAEPFPGFKPAQPVVFSGLYPTDTEDYRKLRDALEKLKLNDAAFSFEPETSEALGFGFRCGFLGLLHAEIIQERLEREYDLDLIATAPAVVYRVTLTNGEIFETQNPAEFPTRDRIEKVEEPYIKLSVMLPEDYVGPVMQLLQERRGSMQTMNYVGKRVELVYEVPFAEILYDFHDRLKSISRGYASMDYEQLGYREGDLRKVDIMVNNEVIDALAVIVHESKTYSLGRKIVDKMAEVIPRQMFPVPVQAVIGAKIIARATVKAYRKDVLAKCYGGDISRKKKLLEKQKKGRARMKQFGTVEVPQEAFLAVLSTEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4400_PSEP1
Sequence: MAAASPTRAGQAAETQALEYLQGQGLQLLARNWRCKGGELDLVMLDADTVVFVEVRYRLHAGFGGALDSIDGRKQKRLVLAASLFLQKEAHWGNHPCRFDVVALQGSHHAGRPLQWLKNAFEC
What are the official names of this protein?
UPF0102 protein Pput_4400.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RS13_PSEE4
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQKICADAGVNPAAKIKDLSDEQIETLRGEVAKFTTEGDLRRDINMKIKRLMDLGCYRGLRHRKGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: STB1B_DANRE
Sequence: MEMELEPELEEELGVSLDELRKWIEEQVDSSEAVQKRKADLEQLQEWVEQREKEVADIDALCSNASESVVQCEALVKEVYSNMGLVYRESSSDDEGGKANPSEVIEIDDDDDDDVIAVGCLVPPKKSLTQAKDPALKEASAALQRTSQQVQNLAQTVNRTAQSGVTTPVKTGGPPGQGPLAVPAVFMSSAPRNTPTQPNPNIKQDSIKINMTLLGKKRTKTWHRGTLVAIKQVGNNLKYKVRFENKGKSLLSGNHVAFEYHPTLERLFVGARVVARYKDGNQVWLYAGVVAEMPNSKNRMRFLIFFDDGYASYVGLPELYPICRPLKKTWEDIEDASCRDFIEEYITSYPNRPMVLLKPGQIIKTEWEGTWWKSRVEEVDGSLVKMLFLDDKRSEWIYRGSTRLEPMFNLKMNTANSQEKKMAGQQRQRPNMGALRTKGPVVQYTSDNSAAASTGGGAATPGTPTRPVAPQPAGPPQPSRTESPSFKSQMAKKSTGQLALQPRQGMPSDLQPKPIINALQTNTSRLFLLQSGPVHTLTPITPAPQTVQTAISTYTNERVPQEPSYQAPNDRLFYLTHNCSPECLKRIRPTRPNLHRGRNPLLTPLLYEFRRMTGRRRLNRKMSFHVIYKSPCGLSLRNMTEIQRYLFQTQCDFIFLEMFCLDPYVLVDRRFQPQRPFYFIRDITSGREDIPLSCVNEIDNTPPPSVAYSKERIPEDGVYINTSADFLVGCDCTDGCRDKSKCSCHQLTLQATGCTPGGQINPNAGYHYKRLDECLPTGIYECNKRCRCNMQMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESEAHCSDSEGSGVDMSRVKLPASSRHGKSNKMEERNSSTTGKSQDDSSEESDDEKDDDSNEDDSDSSDDTFVKDTYYTTSSVWRSYTTRRQAKGLKEESQDSKDGMSVSAGEDRKPPHMPEETGKSKVASWLTNQSSTSANQSVKVEGGIKTEKKDVMTLSDSDDVQTISSGSDDNKEREKKTQAVVKRQVAVKSTRGIALKSHSMMVKSGGGGAGGGGSGPSHGHGGGGGDNGPKNTRLFFDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGSTECRGRLLQIIKTEWEGTWW
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3.  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.  H3 'Lys-9' trimethylation is coordinated with DNA methylation.  Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes.  Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs).  Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase SETDB1-B, SET domain bifurcated 1B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin (By similarity).
Protein: NDK_CHLPB
Sequence: MERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTKLTTETAGAFYAVHRERPFFGELVEFMSSGPCVPMILEKENAVEDFRKLIGATDPAEAEEGTVRKLYADSKGENIVHGSDSEENAQIESSFFFSTEEAVRVNN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_AKKM8
Sequence: MSLVRTRFAPSPTGYLHIGGARTALFNWLFARKMGGTFILRIEDTDNARNTEEATRAIFTGMEWLGLDWDEGPMKGGDCGPYFQSQRNDIYDAYFKKLQDAGRVYEDEGAWRFRFDRSKPVTFHDLICGNITIDYRDASNTPDMAIRRADGSYIFHFVNVVDDIEMKMTHVIRGEDHIMNTPKHIQLFEAFGVTPPVFAHMPLILNQDGSKMSKRDVGAALGTYPEEGFLPEGVMNFLALLGWSPKDDTEIFSPQELIGRFSLEAVNHSAAKFDITKCRWVNQQHIIALPAEEFALRARPFCLKAGLPDSPILDAAIATVQTKVQTLAEVPDKIRFFFDLGMDPEAVSKVQPEALELLFKLADRLEQEPEWDGHELIGVLKAFAKENGVKMGAVMFPARVALTGLSGGPDLSSVFSLLGREETVRRIRSFSLD
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_PROMS
Sequence: MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALEKKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLILCKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTLINRGINIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQCKERVLTLCNRFPLYEGKLEASIK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER_BUCAP
Sequence: MPKIFFLPHKLLLPKGGCFECKEGETILNVALKNNIKLEHACEKSCACSTCHCIIRKGFLSLSGWSEKEEDVLDKAWGLESTSRLSCQAIIGNIDIEVQIPLYNTNYIIEN
What is the function of this protein?
Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
2Fe-2S ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
Protein: RS5_ACIBS
Sequence: MAKVEQNEGLVEKLVAVDRVAKVVKGGRIFSFTALTVVGDGNGRVGFGRGKAREVPAAISKALEAARRNMITVDLAGTTLQHPVNARHGASRVYMQPASEGTGVIAGGAMRAVLEAAGVHNVLAKCYGSTNAANVVNATFKGLRDMTSPEKVAAKRGKSVEEIQG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: IHFB_NEIMA
Sequence: MTKSELMVRLAEVFAAKNGTHLLAKDVEYSVKVLVDTMTRSLARGQRIEIRGFGSFDLNHRPARIGRNPKTGERVEVPEKHVPHFKPGKELRERVDLALKENAN
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: IAFRS_STRV4
Sequence: MHAHASRPQARQTTLLRRAALFDFPASADLSPGTEAARHHTIQWLSRFGVFEGHESVAEYDALRFDVLAGLFYPRATGADLNLGSDLVGWYFVFDDQFDGELGSRPEAVARLVADVIRITEEDTAHGRAQDGEGPLLESFRDLWRRISSGRPQVWRDRFRHHWLEYLHSYHREALERTGALPGAGGDAPRSVEAVLALRRHSIGVQPCLDLNEPFGGYTLPPALHGGFPMARMREATDDVVVFTNDIASLDKELAVGDVHNSVIVQWERAGGELEDAVRHIADLANARYRWFEETAARLPALLTEAGADPGTHHAVGRYVDGMRHVMTGNLGWSVRTARYDERGTEAVSGGRQRPWAQLTGAEELIRAGRGAPLPPLGSGSGSR
What is the function of this protein?
Catalyzes the cyclization of farnesyl diphosphate (FPP) to isoafricanol.
What are the official names of this protein?
Isoafricanol synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: FTSK2_NEIMA
Sequence: MFWIVLIVILLLALAGLFFVRAQSEREWMREVSAWQEKKGEKQAELPEIKDGMPDFPELALMLFHAVKTAVYWLFVGVVRFCRNYLAHESEPDRPVPPASANRADVPTASDGYSDSGNGTEEAETEEAEAAEEEAADTEDIATAVIDNRRIPFDRSIAEGLMPSESEISPVRPVFKEITLEEATRALNSAALRETKKRYIDAFEKNETAVPKVRVSDTPMEGLQIIGLDDPVLQRTYSRMFDADKEAFSESADYGFEPYFEKQHPSAFSAVKAENARNAPFRRHAGQGKGQAEAKSPDVSQGQSVSDGTAVRDARRRVSVNLKEPNKATVSAEARISRLIPESRTVVGKRDVEMPSETENVFTETVSSVGYGGPVYDETADIHIEEPAAPDAWVVEPPEVPKVPMPAIDIPPPPPVSEIYNRTYEPPAGFEQVQRSRIAETDHLADDVLNGGWQEETAAIANDGSEGVAERSSGQYLSETEAFGHDSQAVCPFENVPSERPSRRASDTEADEGAFQSEETGAVSEHLPTTDLLLPPLFNPGATQTEEELLENSITIEEKLAEFKVKVKVVDSYSGPVITRYEIEPDVGVRGNSVLNLEKDLARSLGVASIRVVETILGKTCMGLELPNPKRQMIRLSEIFNSPEFAESKSKLTLALGQDITGQPVVTDLGKAPHLLVAGTTGSGKSVGVNAMILSMLFKAAPEDVRMIMIDPKMLELSIYEGIPHLLAPVVTDMKLAANALNWCVNEMEKRYRLMSFMGVRNLAGFNQKIAEAAARGEKIGNPFSLTPDNPEPLEKLPFIVVVVDEFADLMMTAGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQMGAENLLGQGDMLFLPPGTAYPQRVHGAFASDEEVHRVVEYLKQFGEPDYVDDILSGGMSDDLLGISRSGDGETDPMYDEAVSVVLKTRKASISGVQRALRIGYNRAARLIDQMEAEGIVSAPEHNGNRTILVPLDNA
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK 2.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Located at the septum.
Protein: PRDX1_DROME
Sequence: MPQLQKPAPAFAGTAVVNGVFKDIKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSESAAEFRKINCEVIGCSTDSQFTHLAWINTPRKQGGLGSMDIPLLADKSMKVARDYGVLDEETGIPFRGLFIIDDKQNLRQITVNDLPVGRSVEETLRLVQAFQYTDKYGEVCPANWKPGQKTMVADPTKSKEYFETTS
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.  Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity).  Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
What are the official names of this protein?
Peroxiredoxin 1, Cytosolic thioredoxin peroxidase, DPx-4783, DmTPx-1, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin 1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA3_PSEAE
Sequence: MFSRDLTLARYDAELFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPHKRYYGGCEYVDIVEQLAIDRAKQLFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQVLDFARFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANEEIEKKLNSAVFPSAQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVLKNAQSMAQVFLDRGFDVVSGGTQNHLFLLSLIKQDITGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRIGTPAVTTRGFKEAECRELAGWICDILENMGDESVVDGVREKVKAICAKFPVYGN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 3, SHMT 3, Serine methylase 3.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIMP3_XENLA
Sequence: MSVCALTLILGCFLLFLGDISKPAEGCTCAPSHPQDAFCNSDIVIRAKVVGKKLMKDGPFGTMRYTVKQMKMYRGFNKMPQVQYIYTEASESLCGVKLEVNKYQYLITGRVYEGKVYTGLCNLIERWEKLTFAQRKGLNHRYPLGCTCKIKPCYYLPCFITSKNECLWTDMLSNFGYPGYQSKNYACIKQKEGYCSWYRGWAPPDKTTINTTDP
What is the function of this protein?
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.  May form part of a tissue-specific acute response to remodeling stimuli.
What are the official names of this protein?
Metalloproteinase inhibitor 3, Tissue inhibitor of metalloproteinases 3, TIMP-3.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PEPQ_ECOUT
Sequence: MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPNSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: HIS4_GEOMG
Sequence: MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQARAWERQGAELLHIVDLDGAFAGEPKNRASIEAIVKAIAIPTQLGGGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLFPGRIVVGIDAKDGMVAVQGWAEVTGVTAVDLAKRFEGYGVAAIIYTDIARDGMMQGPNIAATRALAEAISIPVIASGGVSSLKDIENLMTIEASGIAGAITGKAVYTGAINLAEAVALTKRGGA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1185_METJA
Sequence: MKNALINATTKKFEIIEKTVLPITWGLYWHNKFETWKYDAYDEKNVFCFGSGVLPVIGGHRLIFSFRSPLWDGFYFSSMGGAGYQFKSTGLNNVAIIGRCENPSILVIENDGQLRIDFIEVKEELKTVYEVSKYILELYKDKNLRSVVVGEAAKRTNMGGLFSQTVRNGKFVEGSEDWAARGGGGSVLYRAHNIMGIVFFGDEKEDKEEKEKAKKIIESYYKKPMSKVVLEHTKKYRYDEETKTGGTFGNNWLLYKEKVPIFNWRMPYIDKEDRKKILEKILKFYLEIFNKETIEPKRWANCGEPCPVLCKKYRNKNKVDYEPYASNGTLLGIFDLYEADRVVKTADALGFDAIEIGNLTAWVFELLDVGLLKEEELNIKKPIFDYKKITNDDDEEIREISKHNAEQAIKFMHNLAENSNDLYKILSLGKRKAAKILNERFKSRVNKIGKKFNDFAVYVPFGDWGEIAPNLYWTPGFFMPFVIQGRYLTYYKPEFNEPEKLAELVVESIKLELPIENLGICRFHRKWLKPVLKELVKELLGIEDIVEDSINLYREICEYNKKIGYPAKIESERVKDLIIAMAKEFGNEEWTKKFENKENVDEYVKRVLNKYSELLGIDWRIS
What are the official names of this protein?
Uncharacterized protein MJ1185.
What is the protein family that this protein belongs to?
Belongs to the AOR/FOR family.
Protein: RL4_METM5
Sequence: MNVKVYNLDGSEKGDIELPAVFETEYRPDLIKRAVISSLTAKLQPKGCDAFAGYRTSAKSIGKGHGKARVRRTAQGAGAFVPQAVGGRRAHPPKVEKILFERINKKEKLKALASAIAASAIPEIVSARGHKIEGVPSLPLVVNAEFEGLVKTKEVLDVFKALNLAADVEKAKDGIKIKAGRAKLRGRKYKKPRSVLVVVGDACEAIAASRNLAGVDVITANDLSAIHIAPGTMAGRLTLWTENAIEKINGRF
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PLPL_ASPTN
Sequence: MTDSAIGNVYDPRALPDYDREFIHPDDLRRFENALNDQDVLPLVALNDWRPVYQRVRKTRGRRKEPRRTKDETREGVLYTVLKWPFLAFVLGWISFLGVAYILTRFYIFIYEQWVSWRGKRQSLRKQLYVQTNYRDWLKAAEALDAHLGNHAWKEIDENAYYDHITINKLVSQLRKLRQDAEWEMHHEQVNAAESPAVEELCTILEACVKNNFAGVENPRLYSETYSGTKVLVQEYVDEVKACLELVAESKQISDEDKYHHFKHLDTNFGRTALCLSGGATFAYYHFGVVRALLDNNVLPEIITGTSGGALVAALVATRTDEELKQLLVPALAHRIRACHEGFTTWVRRWWRTGARFDTLEWARQCSWFCRGSTTFREAYERTGRILNVSCVPSDPHSPTILANYLTSPNCVIWSAVLASAAVPGILNPVVLMTKKRDGTLAPYSFGHKWKDGSLRTDIPIKALNLHFNVNFTIVSQVNPHINLFFFSSRGAVGRPVTHRKGRGWRGGFLGSAIEQYIKLDMNKWLRVLRHLELLPRPMGQDWSEIWLQKFSGTVTIWPKTVPSDFYYILSDPTPERLARMIHMGQQSAFPKIQFIKNRLKIEYAIIKGLQQTAPRGGGRATSPTQLRLRNGHGNGPVNPIDERLDQNLPERTGEYSKEADANSAEMSDSSGVDSATASALREARHPRRNSMLVEMQRQSAVFFDDVDSDTWKGQ
What is the function of this protein?
Probable lipid hydrolase.
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein ATEG_02594.
What is the protein family that this protein belongs to?
Belongs to the PLPL family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TATE_EDWI9
Sequence: MEGISITKLLVIAVLIVLLFGTNKLRTLGSDLGAALKGFKKAMNDETPAAKKSDGVEAAPRVENKE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatE shares overlapping functions with TatA.
What are the official names of this protein?
Probable Sec-independent protein translocase protein TatE.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family. TatE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ATPD_TROW8
Sequence: MPGSSSRSSLAHLRNRLSECSDLQSLYEVAVLLAISRRLRSSLVSRSLSCVSKQKLIAELTGKDPDAFICMAVSLRWSEPIDLLYAFEEMFIRASCTRRFADCRDFLDELFWVSSIVDSHKILDKTLSARFLPAYSKKQLISGVFAGAHEGTLAVLEYFACYMQKKRAFRECVFFAEKIVADELGAQIADVTTERPLSREQRDELVDVLSRRFKRRIILREVINEKVFGGVRVQVNHSVIDDTVAVHLNNLALSFGALETFS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL18_BUCAP
Sequence: MMFYRNKKIISRTRRLLKARCKIKSLGAIRLVVHRTSRHMYAQIISSESKVLAFASTLESKIKSDLKYTGNKEAAEIVGKIIAKRALLKGISNVSFDRSGFKYHGRIKKLADSARNFGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.