PharMolix/UniProtQA huggingface dataset:
Protein: EFP_POLNA
Sequence: MKIAQEIRAGNVIMNGKDPMVVLKTEYSRGGRNSATVRMKLKSLIANFNTEVVFKADDKIDQVILDKKECTYSYFADPMYICMDTEYNQYEVEAENMGDSLNYLQDGMELEVVFYDGKAISVEVPTSVQREITWTEPAVKGDTSGKVLKPAKLATGFEIGVPIFVAQGDVVEIDTRTGEYRKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_CHLPB
Sequence: MARFRGSITKVSRRLGVALSPKAEKYLEKRPYAPGEHGQSRRGKVSEYALQLREKQKMKYLYGVLEKQFRNYYKKAVSQRGITGDNLVKLLERRFDNVVFRAGFSPSRAGARQLVTHGHLLINGKKVDIPSYLLKPGDAMEFRQKSQNLDAVADSMNRAPDSRIPSWIQVDKAHKKAVFLAVPEREEVQEPFNEQLVVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GLB_PAREP
Sequence: MTLTKHEQDILLKELGPHVDTPAHIVETGLGAYHALFTAHPQYIIHFSRLEGHTIENVMQSEGIKHYARTLTEAIVHMLKEISNDAEVKKIAAQYGKDHTSRKVTKDEFMSGEPIFTKYFQNLVKDAEGKAAVEKFLKHVFPMMAAEI
What is the function of this protein?
Oxygen binding protein.
What are the official names of this protein?
Globin-3, Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SURE_ANADF
Sequence: MRVLLSNDDGVHAPGLKALADAFEGDEVWVVAPDREQSASSHAISLHRPLRLFEMAPRWYAVDGTPTDAVYMGLNHVLRGARPDVVVSGINHGPNLGNDVLYSGTVAAAMEGALLGVHALAVSLACSPPHVFDEAARFAVALARRVVATQPPAPLLLNVNVPRGPVRGYRFTRLGRRTYGNEVVEKTDPRGRKYYWIGGEGGPTNEDIPGSDCNCVLGEGLVAVTPLHLDSSHDAVLQGLRSWTVPGYEKEPAL
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC106_HUMAN
Sequence: MNDRSSRRRTMKDDETFEISIPFDEAPHLDPQIFYSLSPSRRNFEEPPEAASSALALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMEAEDHCRMKPGPRRMEGDSRGGAGGEASDPESAASSLSGASEEGSASERRRQKQKGGASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFKR
What is the function of this protein?
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
What are the official names of this protein?
Coiled-coil domain-containing protein 106.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with p53/TP53.
Protein: FAP1_SCHPO
Sequence: MVKNTSVIIVGAGVFGLSAALELTKRGGYTIKILDRAPPPVIDGSSVDANRIIRSDYADAVYCSMGIDALEEWRTNPLFKEQFYGSGLMFVGRDNVEYRDMSLENLTKMGVSAAKFQTTEELRKLFPKWIGELNDGEAGYANFSSGWANAEQSVKSVVNYLAHAGVSFISGPEGTVEELITEENVVKGVRTTTGAYMAEKLIFATGAWTASLLPNDHTRFLATGQPVAYIKLTPEEYIRFLTNPVYLDFDTGFYIFPPTPDGYLKFARHGYGFTRMQNLKSGKVESVPPKKPLVSPILPKEAELDLRRNLQRTYGEEISQRPFYKTRICYYTDTADAEFVFDYHPDYENLFVCTGGSGHGFKFFPILGKYSIGCMFRELEEPLLKKWRWKKENLEFAALDHSRAGPSRQELS
What is the function of this protein?
Oxidizes L-pipecolate and L-proline (6,7% of the activity for L-pipecolate).
What are the official names of this protein?
L-pipecolate oxidase, L-pipecolic acid oxidase.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Nucleus.
Protein: JMJD7_MOUSE
Sequence: MAEAALEAVRRALQEFPAAARDLNVPRVVPYLDEPPSPLCFYRDWVCPNRPCIIRNALQHWPALQKWSLSYLRATVGSTEVSVAVTPDGYADAVRGDRFVMPAERRLPISHVLDVLEGRAQHPGVLYVQKQCSNLPTELPQLLSDIESHVPWASESLGKMPDAVNFWLGDASAVTSLHKDHYENLYCVVSGEKHFLLHPPSDRPFIPYNLYTPATYQLTEEGTFRVVDEEAMEKVPWIPLDPLAPDLTQYPSYSQAQALHCTVRAGEMLYLPALWFHHVQQSHGCIAVNFWYDMEYDLKYSYFQLMDTLTRATGLD
What is the function of this protein?
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961) (By similarity).  Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961).  Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4.  After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961).  Additionally, may play a role in protein biosynthesis by modifying the translation machinery.  Acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (By similarity).
What are the official names of this protein?
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7, JmjC domain-containing protein 7, Jumonji domain-containing protein 7, L-lysine (3S)-hydroxylase Jmjd7.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PT10_PINTA
Sequence: MDLISVLPSASKSCVCLHKPLSSSTHKLKPFCKTIRILVMPRRWEFARPSMSLSTVASEDDIQRRTGGYLSNLWNDDVIQFLSTPYGELAYRERAERLIDEVRDIFSSMSLEDGEFSDLIQRLWMVDNVERLGIDRHFKNEIKSALDYVYSYWSEKGIGCGTKSIITNLNSTALGFRTLRLHGYPVSADVLKHFRNQIGQFVSCPSETEEDIRIMVNLYRASLIAFPVAFPGEKVMEEAESFSEKYLKETLQKIPDCSLSREIGDVLEHGWHTNLPRLEARNYIDVFGQDTKNMEPNRKTEKLLELAKLEFNIFQSIQKTELESLLRWWNDSGSPQITFTRHRHVEYYTLASCIAFEPQHSGFRLGFAKACHILTVLDDMYDLFGTVDELKLFTAAIKRWDPSATDCLPQYMKGIYMMVYNTVNEMSAEAQKAQGRDTLNYARQAWEDCLDSHMQEAKWIATGFLPTFEEYLENGKVSSAHRVSALQPMLTMDIPFPPHILKEVDFPSNLNDLACAMLRLRGDTRCYQADRARGEETSCISCYMKDNPGATEEDALNHLNVMISGVIKELNWELLKPNSSVPISSKKINFDITRAFHYGYKYRDGYSVSSVETKSLVMRTLLEPVPL
What is the function of this protein?
Involved in defensive oleoresin formation in conifers in response to insect attack or other injury.  Involved in monoterpene (C10) olefins biosynthesis.  Produces 57. 3% alpha-terpineol (15. 1% (+)/84. 9% (-)), 27. 6% limonene (25. 2% (+)/74. 8% (-)), 8% terpinolene, 4. 7% beta-pinene (14. 8% (+)/85. 2% (-)), 1. 3% alpha-pinene (100% (+)) and 1. 1% myrcene.
What are the official names of this protein?
(-)-alpha-terpineol synthase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROA_BRUSU
Sequence: MSHSACPKPATARHSQALTGEIRIPGDKSISHRSFMFGGLASGKTRITGLLEGEDVINTGRAMQAMGARIRKEGDVWIINGVGNGCLLQPEAPLDFGNAGTGARLTMGLVGTYDMKTSFIGDASLSKRPMGRVLNPLREMGVQVEAAEGDRMPLTLIGPRTANPIAYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLQGFGADLTVETDKDGVRHIRIVGQGKLTGQTIDVPGDPSSTAFPLVAALLVEGSDVTIRNVLMNPTRTGLILTLQEMGADIEIIDPRLAGGEDVADLRVRASKLKGVVVPPERAPSMIDEYPVLAIAASFAEGETVMDGLDELRVKESDRLAAVARGLEANGVDCTEGEMSLTVRGRPGGKGLGGGTVATHLDHRIAMSFLVMGLASEKPVTVDDSTMIATSFPEFMGMMAGLGAKIAESGAE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEFN_DICDI
Sequence: MSYNSLTTIDIDITQLLHLKSVNLRSNKLGNSSGVSYFGSMDTLQKLNLKENYLTELPSTFYLLKLSSLKLDTFTPLYQQQQQQQNQLQRPIINSQSTSNESLIHEINRSFENLSMSEPVSPRIAALKNEKKGPPKPLPKTKGLHSSSSNINTSNNITPILMSPIHDGNKKSPSIISNNNNNNNSNSNIITSNGTVIPQLVFKNEPTGGRLRSFTLDADHISPGRELVSTGSSDEILYFNSEGGCENSDSDEPIQPLSAGRSRAQTISGKQPSIINNNNNNNSGGGSGNNNNSGGGGGSRKAFQNLIKSAKQIGSNIKNKTHHINGHSSSSQSNSTTNTPSISSTPYPTSTIKTNVSDTNTPVNYNGQQQISKVIQRVSGEIDPLYSGIDSPRTLERRNSSRDDIPISPPQGCMTPIKRLGSVEGDEISAIFSSSTDANMDVSQDYSSSTPTVNSMSYQSSFLDTFDNQSTVGSPTFYQLPVSSQPPQHPPPPPPIKDNNQPKLNQSQNLINTNSNSVTTTNNSSQTTTTTTTTTTNNNNVLNLEKLHKLDFAEDINGDERCSNPLYSKKKLAGLLFPNKHHQPSALKTAKIRFKSSKRLATTVNSNSSNNLMMSNSPLSSSSMNLLQQSNSPQYSGTPTSGSFQNQSVLSATLMSSPSMSDVFSGGNSQGGGSSLSQSGSITPVAPLSAVQGSPIGNSGSVNNIYLEGDDFIRDLMQSPIINQEIEFTSEDGVPKVKNITLKMLTSLLTHEKGQSNELNGIFFDTYLLFTSIPLVIEHLESRFLNGKNHIVKQKVITFSQKWVEVCWSDFKEEHIELLLKFLNDCSEQIEKLVTGSFALRTSLNLLLNIINMKRDGTYITEEEETFEQPAPIPDFIQLPNCVDINLMDLRPHEIARQLTILDHELLTQITKQQMLDYAVHQTNSPSIVKVTDRFNYLVLWVSTEIVLSLTIEKRIETIFKFVNIALNCWYLKNFNSAIAIIAAMSKPSIEKLKQTWGFIRNTKANAPIQELKELILPTNVARLRKIMDSVEAPFIPYLGAYFSHSIAIHAGNKSIVNEQYINMQKYDMMGKIIRSITVAQEKKYNLTPVGVLQKFLTDSFVLTEKQLYSEASKIEEKGDSYITETTKFGSIFKKKDK
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP (By similarity).  May play a role in chemotaxis.
What are the official names of this protein?
Ras guanine nucleotide exchange factor N, RasGEF domain-containing protein N.
Protein: GLIP1_MOUSE
Sequence: MQVILAVIVWMASSVSSSSFTASTLPDITNEDFIKECVQVHNQLRSKVSPPARNMLYMSWDPKLAQIAKAWTKSCEFKHNPQLHSRIHPNFTALGENIWLGSLSIFSVSSAISAWYEEIKHYDFSTRKCRHVCGHYTQVVWADSYKLGCAVQLCPNGANFICDYGPAGNYPTWPYKQGATCSDCPKDDKCLNSLCINPRRDQVSRYYSVDYPDWPIYLRNRYTSLFLIAKSVLLLLSVIITIWVKHKYPNLVLLD
What are the official names of this protein?
Glioma pathogenesis-related protein 1, GliPR 1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: VPP2_YEAST
Sequence: MNQEEAIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVERMVGFLNEVVEKHAAETWKYILHIDDEGNDIAQPDMADLINTMEPLSLENVNDMVKEITDCESRARQLDESLDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLSDAFSFDDETPQDRGALGNDLTRNQSVEDLSFLEQGYQHRYMITGSIRRTKVDILNRILWRLLRGNLIFQNFPIEEPLLEGKEKVEKDCFIIFTHGETLLKKVKRVIDSLNGKIVSLNTRSSELVDTLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQESQGLIAEGWVPSTELIHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKEINAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRDEIFDMAFTGRYVLLLMGAFSVYTGLLYNDIFSKSMTIFKSGWQWPSTFRKGESIEAKKTGVYPFGLDFAWHGTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLSWAIVYKWSKDWIKDDKPAPGLLNMLINMFLAPGTIDDQLYSGQAKLQVVLLLAALVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQGMIISDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7514599, PubMed:11278748).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:11278748, PubMed:7514599).  Is present only in Golgi- and endosome-residing V-ATPase complexes; enzymes containing this subunit have a 4-fold lower ratio of proton transport to ATP hydrolysis than complexes containing the vacuolar isoform and do not dissociate V1 and V0 in response to glucose depletion (PubMed:11278748, PubMed:7514599).
What are the official names of this protein?
V-type proton ATPase subunit a, Golgi isoform, V-ATPase a 2 subunit, Similar to VPH1 protein 1, V-ATPase 101 kDa subunit, V-ATPase subunit AC115, Vacuolar proton translocating ATPase subunit a 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase 116 kDa subunit family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: G3P_HAEIN
Sequence: MAIKIGINGFGRIGRIVFRAAQHRDDIEVVGINDLIDVEYMAYMLKYDSTHGRFDGTVEVKDGNLVVNGKTIRVTAERDPANLNWGAIGVDIAVEATGLFLTDETARKHITAGAKKVVLTGPSKDATPMFVRGVNFNAYAGQDIVSNASCTTNCLAPLARVVHETFGIKDGLMTTVHATTATQKTVDGPSAKDWRGGRGASQNIIPSSTGAAKAVGKVLPALNGKLTGMAFRVPTPNVSVVDLTVNLEKPASYDAIKQAIKDAAEGKTFNGELKGVLGYTEDAVVSTDFNGCALTSVFDADAGIALTDSFVKLVSWYDNETGYSNKVLDLVAHIYNYKG
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_EHRRG
Sequence: MLSNYVVKEILNDNKLKREYEFTIDNKYFFSQLDAKLLEIAKNVKIPGFRAGKASIDLIKKEYLNNAVNTLIRKIVEDTSSEFIKNGKFGEIISSNVSVISCPDYGMGVSSTSGDPAGDNLVYKLSFEVMPEAPLIALDDIVLSDIEADIQDSDISEFIENLKKQCSEFVEVSDSEYRVKMGDKVVVDYQNRIKGKMLKGGDTKDLAVIVGRGLVLKDFEDQLIGMKIGESKSFPIQFPDNYGVAYLVGKSADVSVTVKNIFMMKAIEENENVIKYYQFKDEQALKDFARNKIKQQFDKISFAIVKKELFDYLDKTYSIDVPECVVTKEIDKINQEIQDSAGTVQVDVKAEAMKRVKLGILLVKMSRHHNISINKDDVFSFINTYYSDYGISLNDVLRMLQSNKDFANYISGKVLEDKVINYIIRLVKKDKKVMTTQELNLMLENM
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ASPQ_PSEAE
Sequence: MKPLLHAFAPGVMALMLLLPQAAQAKEVAPQQKLSNVVILATGGTIAGAGASAANSATYTAAKVPVDQLLASVPQLKDIANVRGEQVFQIASESFTNENLLELGKTVAKLADSDDVDGIVITHGTDTLEETAYFLTLVEHTEKPIVVVGSMRPGTAMSADGMLNLYNAVAVAGDKSARGKGVLITMNDEILSGRDASKMVNIKTEAFKSPWGPLGMVVEGKSYWFRAPVKRHTVNSEFDIKQISALAPVEIAYSYGNVSDTAYKALAQAGAKAIIHAGTGNGSVPARVVPTLQELRKQGVQIIRSSHVNAGGFVLRNAEQPDDKNDWIVAHDLNPQKARILAAVAMTKTQDSKELQRIFWEY
What are the official names of this protein?
Glutaminase-asparaginase, L-ASNase/L-GLNase, L-asparagine/L-glutamine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ZBT43_HUMAN
Sequence: MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEGASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNLIGHRQEAALAAGYSENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAEQNTTEAN
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 43, Zinc finger and BTB domain-containing protein 22B, Zinc finger protein 297B, ZnF-x.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LECA_LATCY
Sequence: ATSYTLNEVVPLKEFVPEWVRIGFSATTGAEFAAHEVLSWSFHSELAGTSSSN
What are the official names of this protein?
Lectin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: TRI26_MOUSE
Sequence: MAVSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPISGNRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDNGRQPGELAREPQDMKLCERHQEKLHYYCEDDGKLLCVMCRESREHRPHTAVLVEKAALPHREKILNHLNTLRRDRDKIQGFQAKGEADILAALTKLQEQRQYIVAEFKQGHQFLKKREQHLLDQLATLEQLLTEGREKFKTRGVSELDRLTLVISELEGKARQPAAELMQDVCTTQDTKDFANKYPRKKFWIGKAIPHMVKRKAGEFSDKLLSLQRGLRQFQGKLLRDLEYKTVSVTLDPQSASGYLHLSEDWKCVTYTGQYQSDCLLPQQFDCEPGVLGSKGFTWGKVYWEVELEREGWSEDEEEGEEEEEGEEEEEDEEVGYGDGYEDWETDEEDESLGEEEEEEEEEEEEVQESCMVGVAKDSVKRKGDLSLRPEDGVWALRLSPSGIWANTSPEAQLFPVLRPRRVGIALDYEGGTVTFTNAESQELIYTFTTTFTRRLVPFLWLKWPGARLLLRP
What is the function of this protein?
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs).  Promotes nuclear IRF3 ubiquitination and proteasomal degradation.  Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
What are the official names of this protein?
Tripartite motif-containing protein 26, Zinc finger protein 173.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation.
Protein: GLPK_BRUO2
Sequence: MSGYILAIDQGTTSTRSMLFDRNMRVVGLGQQEFTQHFPSSGWVEHDAEEIWKSVQSTIRIALAQAGISAADVAAIGITNQRETTVVWDRISGKPVHRAIVWQDRRTAQFCDELKRRNLEPLFTEKTGLLLDPYFSGTKLAWLLNHVPGLRERAQKGQVCFGTIDSWLIYKLTGGKAHVTDATNASRTLIYHIGENRWDDELLDILGIPAAMLPEVKDCAADFGMTDPALFGVSIPILGVAGDQQAAVIGNACFEPGMMKSTYGTGCFALLNTGTDRVTSSNRLLTTIAYRLDGVTTYALEGSIFIAGAAVQWLRDEMGFISVASEVSALAEKADPNQRIYLVPAFTGLGAPYWDAEARGAIFGLTRGTGRAEFARAALESVAYQTFDLLEAMQGDWKGATNHTVLRVDGGMVASDWTMQRLADILNAPVDRPVFLETTVLGAAWLAASRAGIWPDRKGFSERWQRDCRFEPAMPEKERESAIAGWRDSVSRCLTRPQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PSRP_ALTMD
Sequence: MRTAFYISDGTAITAEVFGHALLSLFPVSFNHNTIPFVETEEQAHKVLQQISESFQDTGERPLVFYTIVNVDVRKIISKSVGINYNFLDQFVAPLEKVLGVPSKPEKHRTHSIHETTYDIRIEAVNYALANDDGSNLKDYDEADIILTGVSRSGKTPTSLYLALQYGIKAANYPFTEEDMGDMLKLPPTLRRYKHKLFGLTIAADRLHQIRSERRANSKYASIQQCRMELREVENLYRKEKIPFLNSTKYSIEEISAKILAETGLKRRKY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: NGF_SAIBB
Sequence: MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAGPIAARVAGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPEAADTQDLDFEVAGAAPVNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKASRRA
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.  Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
What are the official names of this protein?
Beta-nerve growth factor, Beta-NGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECU_ALKCK
Sequence: MPIRYPNGQPYSRSPKQGQAKKPLPADTYSGRGMTLEQDIDEANLYYLSQQRAVVHKKPTPVQIVKVDYPKRSAAVIREAYFKQASTTDYNGVYRGAYIDFEAKETKNKTSFPLKNIHPHQVDHMREVSKHGGICFVLIRFFQSAEVFLLDAKHLIDYYDNQDVRKSIKKTEIERLGHQVKTGLHPPIDYLRTLDAVYFNGDAKERT
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_RUMCH
Sequence: MIEIEKPRIECVSNSDDNTYGKFIVEPLERGYGITLGNSLRRILLSSLPGSAVNSIKIDGVLHEFSTVPGVVEDVTEIILNIKSLSLLVHGEGSKVIYIDANGEGPITAGDIITDQDVEILNPDLHIATLNGDHRFYMEMVISKGRGYVSADKNKQAGQPIGVIPVDSIYTPVKKVNYTVENTRVGQITDYDKLTLEVWTDGSINPDEAISLGAKILSEHLNLFVDLSDQAKHTEIMVEKEETKKEKVLEMTIEELDLSVRSYNCLKRAGINTVEDLTNRTEEDMMKVRNLGRKSLEEVLQKLQALGLFLAPSEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RS12_RICRS
Sequence: MPTYNQLVRFGRKSKTRKTKSPALESNPFKSGVCLVVKTVTPKKPNSALRKIATVRLSNKRTVNAYIPGEKHSVKEHDRVLVRGGQVPDLPGVKYHIVLGAYDIAGVKGRKQGRSRYGAPRKQVAVTKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PIMT_CERS1
Sequence: MTAEADGEDPAERKMRFLFAVRSRGVTDARVLAAMERIDRGAFVRGIFADRAYEDMPLPIACGQTISQPSVVGLMSQALAVNPRDKVLEVGTGSGYQAAVLSQLARRVYTVDRHRRLVREATEVFHRLSLTNITALIADGSFGLPEQAPFDRILVTAAAEDPPGPLLAQLKIGGIMVVPVGQTDAVQNLIKVTRLEQGYDYEELRPVRFVPLVEGIGSD
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_RIPO1
Sequence: MEITELKREIQQIAARLGKTQDYLDLPALNANIQDLEQIAAQPDFWDNQETAQKTLQQLNDLKSSVEEYHQWMGQLEDLKAIAELLELEEDATLNEEAEANLTQLNHELDRWELQRLLSGIYDSKGAVLTINAGAGGTDAQDWAEMLLRMYTRWGEQQGYKVHLTEISEGDEAGIKSATLEIEGRYAYGYLKGEKGTHRLVRISPFNANGKRQTSFAGIEVMPALEEEDLKVEIPEKDLEITTTRSGGKGGQNVNKVETAVRVVHLPTGIAVRCTQERSQLQNKEKALALLKAKLLIIAQEQRAQAIAEIRGDMVEAAWGNQIRNYVFHPYQMVKDVRTNTETTDVNGVMDGKLDLFIESYLRSN
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.