PharMolix/UniProtQA huggingface dataset:
Protein: RBL_NITWI
Sequence: MAVKSYQAGVTQYRQSYWQPDYMPLDTDILACFKITPQPGVDREEAAAAVAAESSCGTWTTVWTDLLTDLDYYKGRAYRLEDVPGDDTCYYAFIAYPIDLFEEGSVVNVFTSLVGNVFGFKAVRALRLEDLRFPIAYVKTCGGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYEALRGGLDFTKDDENINSQPFMRWRDRFDFVMEAVQKAEQETGERKGHYLNVTAPTPEEMYKRAEYAKEIRAPIIMHDYLAGGLCANAGLANWCRNNGMLLHIHRAMHAVIDRNPHHGIHFRVLTKILRPSGGDHLHTGTVVGKLEGDRASTLGWIDLLRESFVPEDRSRGIFFDQDWGSMPGGFAVASGGIHVWHMPALVTIFGDDSVLQFGGGTLGHPWGNAAGAHANRVALEACVQARGEGRHLEKEGKDILTAAAAQSPELKIAMETWKEIKFEFETMDKLAIANK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: RL1_STAAE
Sequence: MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGIDTRKNDQQIRGAVVLPNGTGKSQSVLVFAKGDKIAEAEAAGADYVGEAEYVQKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVKKAVEEIKAGKVEYRAEKAGIVHASIGKVSFTDEQLIENFNTLQDVLAKAKPSSAKGTYFKSVAVTTTMGPGVKIDTASFK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: IMAND_ENTBW
Sequence: MDNITIRDIKVFVTAPRGINLVIVKVETSEPELFGYGCATFTWRHKAVVTAIEEYLCPMLKGRSVHNIEDIWQTMMGSSYWRNGPILNNAISGVDEALWDIKGKLAGMPLYSLLGGKAREGVTVYRHADGGCLEEVKECISRYIEEGYRHIRCHMGTYGGNFDGRRQQMVKPEGAPEGAYFHPKMYMDSVIRLFEQVRKDFGWELEVMHDVHERLSLADTLAFTKELEPFKLFFLEDSLAPDQVGYYKYMREQTAVPFAMGELFTNPAEWKTIIQNQWIDFIRVHLSDIGGITPAVKLAHFCDAYGVRTAWHGPNDLSPIGMCAQMHLDLNSHNFGIQEFSGFTQEEEAVFPGCPKIRDGYAYVDDTPGIGVGFDEKEAAKYPAVDMDHSWLFARLPDGTAVRP
What is the function of this protein?
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding.  May have evolved a divergent function.
What are the official names of this protein?
D-galactonate dehydratase family member CLOBOL_02770.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: HIS1_SYNWW
Sequence: MYDDYLTIALSKGTLLEPTLEVFKKLKLPGEGINDKSRSMVFTYDNERVKYIMCRPTDVPTYVEQGAADLGIVGKDVIVEQARDVFEMVDLQYGYCRFVVAVPEAIKNITLKDLNYKRAATKFPVIAENFFRSQGLQVEIIKLHGNIELAPLMGLADMIVDLVSTGRTLKENRLVELIKIMDSTTRLICNRVSYRTKHQQIQPLIENMQKLSTGGSA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRK_VESMC
Sequence: TATTRRRGRPPGFSPFR
What is the function of this protein?
Induces smooth muscle contraction.  May target bradykinin receptors (BDKRB).  May cause hypotension.
What are the official names of this protein?
Vespulakinin-1.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1183_METJA
Sequence: MGDIMTLKLLKEENGLSPMLREFRTLVRDSNIEKVAFVGSVGVCQPFAELFGYAIRDKECYFIPDGDLNKVKKLVIKDIGMQMEDFENLNKVDAIVLFGGLAMPKYGVEVDKIKELINKLSPKKVIGVCFMSIFQKAGWDKEIDFDYLMDGFIKVSIYCKD
What are the official names of this protein?
Uncharacterized protein MJ1183.
What is the protein family that this protein belongs to?
To M.thermoautotrophicum MTH862.
Protein: RS19_MARMM
Sequence: MPRSVWKGPFVDGYLLKKAEKSHEGGRKQAIKTWSRRSTIMPQFVGLTFQVHNGNKFVPVLVTEDMVGHKLGEFSPSRTYYGHAADKKAKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: GLTL6_HUMAN
Sequence: MKRKQKRFLQMTLLFTVALIFLPNVGLWSLYKDKHLVKSAEPGEQQTFPLGLGDGQFYSWTDGLRRKDWHDYESIQKEAMRSGKGEHGKPYPLTEEDHDDSAYRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKFNHHANS
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase-like 6, Polypeptide GalNAc transferase 17, GalNAc-T17, pp-GaNTase 17, Protein-UDP acetylgalactosaminyltransferase 17, Putative polypeptide N-acetylgalactosaminyltransferase 17, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: BRM_DROME
Sequence: MASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGPPGQGPPGHHMPPHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDDMD
What is the function of this protein?
Transcriptional regulator (PubMed:1346755).  Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters (PubMed:1346755).  Can counteract the repressive effect of Polycomb protein (PubMed:1346755).  ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA (PubMed:1346755).  This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (PubMed:10809665).  In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3 (PubMed:24618901).
What are the official names of this protein?
ATP-dependent helicase brm, Homeotic gene regulator, Protein brahma.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAND_ASPNN
Sequence: MAIIEPQMENQNTIPIYAREETPYDTLSKVLTFSNIDQEEYWRRIAPLLGKLLQQGSNYTIHQQYQHLCFYALHVIPLLGPFPVEGRSSYNCPLGGVGAIEPSQNFQKSGTSLRYTFEPTSTGAISGRSDPFNRFMIDDALSRFRQAGVRFNPHLYEALKKEVLLTDEEAEAICQHHDVPKMEFRAQACIAVDLDGGNMSVKLYVYPMLKATLLNIPNWELCLNAIRHVDGEGQFTSATAALETYLRTQCPTTVREQTSATTQVSYIACDLVDLQRARFKVYLFDLHVSFERIITHWTMGGRLNDEVTMSGLGILRELWDELKIPEGRRKPIERPPKPGDGPTMPLFFNYEMKAGDRLPKVKAYLPLVGMPEMPIARKLAAFFQRYGFPVEGRQYVDTLAGYFPDEDLEIVTHHQAFLSFSYSAKTGPYMTIYYH
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of the benzazepine alkaloid nanangelenin A which contains an unprecedented 3,4-dihydro-1-benzazepine-2,5-dione-N-prenyl-N-acetoxy-anthranilamide scaffold (PubMed:32182055).  The first step of nanangelenin biosynthesis is catalyzed by the indoleamine 2,3-dioxygenase nanC which produces N-formyl-kynurenine through the catabolism of tryptophan (PubMed:32182055).  The two-module NRPS nanA then utilizes anthranilate (Ant) and L-kynurenine (L-Kyn) to assemble the dipeptide product nanangelenin B (PubMed:32182055).  The first adenylation domain of nanA (A1) loads anthranilate onto the T1 domain, while A2 loads kynurenine, generated through spontaneous nonenzymatic deformylation of the nanC-supplied N-formyl-kynurenine (PubMed:32182055).  The peptide bond formation between the tethered amino acids is catalyzed by the first condensation domain (C1) between anthranilate's carbonyl carbon and kynurenine's aliphatic primary amine (PubMed:32182055).  The second C domain (C2) catalyzes the final cyclization event between the aromatic amine of kynurenine and the tethered carbonyl carbon, yielding nanangelenin B (PubMed:32182055).  The terminal T3 domain enhances the catalytic efficiency of C2, suggesting the T2-tethered Ant-L-Kyn is transferred to T3 prior to cyclization by C2 (PubMed:32182055).  Once released from nanA, nanangelenin B is then prenylated by the prenyltransferase nanD to form nanangelenin C (PubMed:32182055).  Nanangelenin C is then N-hydroxylated by the FAD-dependent monooxygenase nanF and further acetylated by the acetyltransferase nanB to yield nanangelenin F (PubMed:32182055).  Finally, the N-methyltransferase nanE methylates the amide nitrogen of 1-benzazepine to convert nanangelenin F into nanangelenin A (PubMed:32182055).  NanE is also able to methylate most of the intermediates of the pathway such as nanangelenin B and nanangelenin C to produce nanangelenin D and nanangelenin E, respectively (PubMed:32182055).
What are the official names of this protein?
Prenyltransferase nanD, Nanangelenin A biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: ADHL4_ARATH
Sequence: METQGKVITCKAAVAWGAGEPLVMEDVKVDPPQRLEVRIRILFTSICHTDLSAWKGENEAQRAYPRILGHEAAGIVESVGEGVEEMMAGDHVLPIFTGECGDCRVCKRDGANLCERFRVDPMKKVMVTDGKTRFFTSKDNKPIYHFLNTSTFSEYTVIDSACVLKVDPLFPLEKISLLSCGVSTGVGAAWNVADIQPASTVAIFGLGAVGLAVAEGARARGASKIIGIDINPDKFQLGREAGISEFINPKESDKAVHERVMEITEGGVEYSFECAGSIEALREAFLSTNSGVGVTVMLGVHASPQLLPIHPMELFQGRSITASVFGGFKPKTQLPFFITQCLQGLLNLDLFISHQLPFHDINEAMQLLHQGKALRCLLHL
What are the official names of this protein?
Alcohol dehydrogenase-like 4.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_PROM0
Sequence: MTLKNRYKESIRPKLLKDLGLKNIHQVPKVVKVNVNRGLGEAASNSKALEASLNEMATITGQKALVTRAKKAIAGFKIREGMPIGCTVTLRGDRMYSFLERFINLALPRIRDFRGVNPKSFDGRGNYTVGVKEQLIFPEISFDKIDSIRGMDITIVTSARSDQEGKALLQELGMPFSKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MDH_AGRVS
Sequence: MARNKIALIGSGMIGGTLAHLAGLKELGDIVLFDIADGVPQGKGLDIAQSSPVEGFNAKLTGSSDYAAIEGADVCIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPNAFVICITNPLDAMVWALQKFSGLPANKVVGMAGVLDSSRFRLFLAEEFNVSVQDVTAFVLGGHGDTMVPLARYSTVGGIPLTDLVKMGWVTAERLEEIIQRTRDGGAEIVGLLKTGSAFYAPAASAIEMAESYLKDKKRVLPCAAHLTGQYGVKDMYVGVPTVIGAGGVERVIEIELNKDEEAAFQKSVGAVAGLCEACINIAPALK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: VL2_HPV6A
Sequence: MAHSRARRRKRASATQLYQTCKLTGTCPPDVIPKVEHNTIADQILKWGSLGVFFGGLGIGTGSGTGGRTGYVPLGTSAKPSITSGPMARPPVVVEPVAPSDPSIVSLIEESAIINAGAPEIVPPAHGGFTITSSETTTPAILDVSVTSHTTTSIFRNPVFTEPSVTQPQPPVEANGHILISAPTITSHPIEEIPLDTFVISSSDSGPTSSTPVPGTAPRPRVGLYSRALHQVQVTDPAFLSTPQRLITYDNPVYEGEDVSVQFSHDSIHNAPDEAFMDIIRLHRPAIASRRGLVRYSRIGQRGSMHTRSGKHIGARIHYFYDISPIAQAAEEIEMHPLVAAQDDTFDIYAESFEPDINPTQHPVTNISDTYLTSTPNTVTQPWGNTTVPLSIPNDLFLQSGPDITFPTAPMGTPFSPVTPALPTGPVFITGSGFYLHPAWYFARKRRKRIPLFFSDVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: KN14H_ORYSJ
Sequence: MASSLTPRSPYPKKENLGNARRGMGVKPGPRRNVLSAINNGGGTNSDTASVDGGEGGAGPAAPVIEFTGREDVERLLAEKMKGKSKTDYKGRTEQMSEYIKKLRACIRWYIELEDGYLVEQEKLRSTMDAENAQHAKLEAQLSSDLEELKAAHLNLTRQCDSLEESFNKEKADRMLAVESYEKERQQRESAEASLDLLSVDLERVSHEAKRFSEQLKMVQDTNKRLQEYNTSLQQYNSNLQADASKSGDIISKLQKEKSAMMETMASLKDLNNSMKNHLDSSRTSQQEAIRMKEQLMKEVDCLRIELHQIREDRDQSVSQVNTLSAELANYKELAGKSTKDCESLSVKVSAFEETCSMQQEQIQTLQKQLAVATNKLKLADVTAIEAMTGYEEQKVIIKDLEERLASAEFQIVEADKLRKKLHNTILELKGNIRVFCRVRPLLQDNDSSGAEEALISYPTSVESAGRGIDLMNQGQRFSFSYDKVFDHGASQEDVFVEMSQLVQSALDGYKVCIFAYGQTGSGKTYTMMGPPGRDQKGIIPRSLEQIFKTSQSLESQGWKYSMQASMLEIYNETIRDLLAPGRSNNFDLSTSKQYTIKHDPQGNTTVTDLTVADVFSSADVTSLLAKASQSRSVGRTQMNEQSSRSHFVFTLKISGSNENTGQQVQGVLNLIDLAGSERLAKSGSTGDRLKETQAINKSLSALSDVIFAIAKGDDHVPFRNSKLTYLLQPCLGGDSKTLMFVNISPEASSVGETICSLRFASRVNACEIGIPRRHTQARSFDSRLSYG
What are the official names of this protein?
Kinesin-like protein KIN-14H.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: CD81_HUMAN
Sequence: MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
What is the function of this protein?
(Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.
What are the official names of this protein?
CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: SYE1_METRJ
Sequence: MSSAVVTRFAPSPTGYLHIGGARTALFNWLYARHTGGKMLLRIEDTDRERSTKGAIDAILDGLSWLGLDWDGDVVFQFARAERHRAVAEELLAAGRAYHCYATAEELAQMRETARAEGRAPRYDGRWRDRDPSEAPAGVKPVIRLRAPIEGETVVEDAVQGRVTWANKDLDDLVLLRSDGTPTYMLAVVVDDHDMGVTQIIRGDDHLTNAARQSQIFSALGWDVPRMAHIPLIHGADGAKLSKRHGALGVEAYRDLGYLPAALRNYLVRLGWSHGDQEVFSTEEMVAAFDLGAVGRSAARFDFAKLANLNGLYIRTSADADLVAAIETILPNVGPERGLSAPLQPDLKDKLIQAMPGLKERAKTLIELLDSAYYLYAQRPLALDDKARALLSDEGRGRLAGVRPVLEALPDWSAASTEGAVRQYAESAGCKLGQVAQPLRAALTGRTTSPPLFDVMAVLGREETLARLGDQAPQG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_SALCH
Sequence: MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMVGETGKVILADINDSMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: YICL_ECOLI
Sequence: MGSTRKGMLNVLIAAVLWGSSGVCAQYIMEQSQMSSQFLTMTRLIFAGLILLTLSFVHGDKIFSIINNHKDAISLLIFSVVGALTVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNPTSLSISPAALFWGIASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRARKINRPARHK
What are the official names of this protein?
Uncharacterized inner membrane transporter YicL.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_CLOBJ
Sequence: MLERLNFIENKYEELSNKISDPSVMANQKEWQKLCKEHADLEIIVNTYREYKKAQEDLESDKEMLKEESDKELREMAQEEIKELTLRLEDLERELTILLLPKDPNDDKDVFIEIRAGAGGEEAALFASNLLRMYTRYAERKNWKVETMSLNATDIGGFKEVTVAIKGKGAYSRLKYESGVHRVQRVPDTESSGRIHTSTATVAVLPEVDDVDININANDLRIDVYRASGHGGQCVNTTDSAVRITHLPTGLVVTCQDEKSQLKNKEKAMKVLKARLFEAAEAERAASIAEDRKSQVGTGDRSERIRTYNYPQGRITDHRIGLTLYKLETFLDGDIDEVIEALVTEDQAEKMKDLGRVN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_VIBVU
Sequence: MSESKQQYLEELKQQLHYHAVRYYVEDNPEIPDAEYDRMMRELMAIEAEHPEWISVDSPSQRVGGVALDSFRQVTHEIPMLSLDNAFSDEELESFLKRAQDRMPSAHIDAFCCEPKLDGLAVSLLYENGVLVQAATRGDGTTGENITENVRTIASVPLKLQGEGWPSRIEVRGEVFMPKAGFEKLNDIARKKGEKVFVNPRNAAAGSLRQLDSKITATRPLAFYAYSVGVVEGISLSSSHYQRFLQLKQWGLPMCPETKLVNGLESVKAFYADILNRRDALPYEIDGVVIKIDDIVIQEKLGFVARAPRWAIAYKFPAQEELTLLNDVEFQVGRTGAITPVAKLEPVFVGGVTVSNATLHNADEIERLGVMVGDTVVIRRAGDVIPQIVSVVKDRRKGDEKNIIFPTACPVCHSHVERIEGEAVTRCSGGLVCQAQRKEALKHFVSRKALDVDGLGDKVIEQLVDKEMVETPADLFTLSAGVLTVLERMGPKSAQNIVNALNVAKETTLARFLYSLGIREVGEATAANLARHFKTLEAIQTATHEQLIEVPDIGEVVARHITAFFAEEKNQRVVQALIEQGIVWPAVEELGSEIPQPLAGKVVVLTGTLTQLSRGDAKAALERLGAKVTGSVSKKTDIVFAGEAAGSKLTKAQELGVEIQTEQDLLALL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VL1_HPV68
Sequence: MALWRASDNMVYLPPPSVAKVVNTDDYVTRTGMYYYAGTSRLLTVGHPYFKVPMSGGRKQGIPKVSAYQYRVFRVTLPDPNKFSVPESTLYNPDTQRMVWACVGVEIGRGQPLGVGLSGHPLYNRLDDTENSPFSSNKNPKDSRDNVAVDCKQTQLCIIGCVPAIGEHWAKGKSCKPTNVQQGDCPPLELVNTPIEDGDMIDTGYGAMDFGTLQETKSEVPLDICQSVCKYPDYLQMSADVYGDSMFFCLRREQLFARHFWNRGGMVGDTIPTDMYIKGTDIRETPSSYVYAPSPSGSMVSSDSQLFNKPYWLHKAQGHNNGICWHNQLFLTVVDTTRSTNFTLSTTTDSTVPAVYDSNKFKEYVRHVEEYDLQFIFQLCTITLSTDVMSYIHTMNPAILDDWNFGVAPPPSASLVDTYRYLQSAAITCQKDAPAPVKKDPYDGLNFWNVDLKEKFSSELDQFPLGRKFLLQAGVRRRPTIGPRKRTATATTTSTSKHKRKRVSK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.