PharMolix/UniProtQA huggingface dataset:
Protein: TRPF_OCEIH
Sequence: MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVDEPLENILSIIERVNLDIVQLHGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILIDSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTENIREAIKTVNPAGVDVSSGVETNGKKDAKKIQQFITNVQRKDVLR
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MYD88_SALSA
Sequence: MSTSLDLWNIPLRALNINVRKRLGLFLNPRNTVASDWMSVAENMGFSYLEIKNYEDCLDPTRRILEDWQARCPGAKVGKLLSILDNVDRKDVVEDLRDLIEEDCRRYIERQNEPPLQVPEVDSCVPKTQERQGITLEDDPEGGIPELFDAFICYCQSDFDFVHEMXQQLEQTDHKLKLCVFDRDVLPGSCVWTITSELIEKRCKRMVVVISDEYLDSDACDFQTKFALSLCPGARSKRLIPVKYRSMKKPFPSILRFLTVCDYTRPCTQSWFWVRLARALSLP
What is the function of this protein?
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
What are the official names of this protein?
Myeloid differentiation primary response protein MyD88.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_RICM5
Sequence: MNPQLNKLTLPIYMDYQATTPIDPRVMEAMLPYFTTKFGNPHSRSHSFGWEAENAVEEARSMVAKLIGADTKEIIFTSGATESNNLAIKGIAKFYSNKKNHIITVVSEHKCVLDACRHLEQEGIKITYLPIKPNGIIDLETLKNAITDQTMLVSVMVVNNEIGVVQPLKEIGKICREKGVFFHSDIAQGFGKIPIDVNEFNIDLASISGHKIYGPKGIGALYVRKKPRVRVTPLINGGGQERGMRSGTLPTPLIVGLGMAAEIAYSEMEKDTKHVNYLFDRFLNNIHKRISEVYLNGDKNQRYKGNVNLSFAGVEGESIILAIKDLAVSSGSACTSASLEPSYVLRSMGIGEELAHTAIRFGIGRFTTEQEVDYAVNLICSKIDKLRELSPLWEMMQEGIDLKKIKWAVH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_AGRFC
Sequence: MNQSFSPEVPQSFFQRDALDVARALIGAEFRVGKAGGIIVETEAYHPDDPASHAFNGQTPRNRAMFGPAGHLYVYRSYGIHWCANFVCAPGSAVLLRAIEPLTGIDMMKLRRGTDKLKLLCSGPGKLCQAMAITGEMDGAPLNAPPFLLRLPKEAAAISTGRRIGISRAVDYPWRFGLEGSAFVSKKFEPDQR
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: BL1S5_MOUSE
Sequence: MSGGGTETPVACDAAQGGKKRDSLGTPGAAHLIIKDLGEIHSRLLDHRPVTQGEIRYFVKEFEEKRGLRELRVLKNLENTIQETNECLLPKCRETMECGLGETLQRLQAANDSICRLQQREQERKKVINDYLTASEKRRLVQWEEFVSGQPQRRAEVDEEHRRAVERLREQYAAMEKDLAKFSTF
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.  The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension.  Plays a role in intracellular vesicle trafficking.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S5 family.
Protein: NFRA1_BACSU
Sequence: MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQAYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLENTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFGLAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKREETWSDQILNFMKQKPRTYLNDYVKEKGFNKN
What is the function of this protein?
Reduces FMNH(2) to FMN, with NADPH as reductant.  It also reduces nitroaromatic compounds, quinones and azo dyes.
What are the official names of this protein?
FMN reductase (NADPH), NADPH-dependent FMN reductase, NADPH-dependent nitro/flavin reductase, NADPH-dependent nitroreductase, NADPH-dependent oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the flavin oxidoreductase frp family.
Protein: ONEC3_MOUSE
Sequence: MELSLESLGGLHGVTHAQAGELLSPGHARSAAAQHRSLVASGRPGLVAGMASLLDGGGAGGGGAGGAGAAGAAGGGPDFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAVADKFHQHAVAGAHGGHPHAHPHPATAPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELPTMGSPLSPLPSALPPALHSAPQPPPPPPLAAYGAPGHLAGDKLLPPAAFEPHAALLGRAEDALARGLPGGGGGAGGGGAAGGAAAGLLAPLGGLAAAGAHGPHSGGGGPGGGGGAGGGSGGPGAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQDQQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQATISQQLGLELNTVSNFFMNARRRCMNRWAEEPGATPGTGTATATFSKA
What is the function of this protein?
Transcriptional activator.  Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.
What are the official names of this protein?
One cut domain family member 3, One cut homeobox 3, Transcription factor ONECUT-3, OC-3.
What is the protein family that this protein belongs to?
Belongs to the CUT homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIG_MACCJ
Sequence: MLKIGPIELESRLILGTGKFENGDIQREAVDASETNALTFAVRRMNLYDKDLPNPLESVDLDKYITFPNTAGAKTAEEAVKIAEIARAAGMCDMIKVEIIGDDKTLLPDAIETYKACEILIERGFIVCPYIQCDVVLAKKLETLGVHAIMPLGSPIGTGLGINDALNLSYIIDAISVPVIVDAGIGSPSDAAYAMELGADAVLLNTAVSHAKDPVKMAEAMKLAVHAGFIGAAAGRIPKKYTAQASSPTEGLEFL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_TROW8
Sequence: MPRSLKKGPFVDMHLLKKVRAGNESKDRNMIKTWSRRSMIIPEMLGHTIAVHDGRRHIPVFITESMVGHKLGEFAPTRTYRGHVKDDRKARRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SC6A3_BOVIN
Sequence: MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDRETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELALGQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHCNHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSCLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFHRLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSAMGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATFRPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGRVDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPPVPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
What is the function of this protein?
Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1722321).  Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity).  Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
What are the official names of this protein?
Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection. Cell projection, axon. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity).
Protein: PPGK_MYCTA
Sequence: MTSTGPETSETPGATTQRHGFGIDVGGSGIKGGIVDLDTGQLIGDRIKLLTPQPATPLAVAKTIAEVVNGFGWRGPLGVTYPGVVTHGVVRTAANVDKSWIGTNARDTIGAELGGQQVTILNDADAAGLAETRYGAGKNNPGLVVLLTFGTGIGSAVIHNGTLIPNTEFGHLEVGGKEAEERAASSVKEKNDWTYPKWAKQVIRVLIAIENAIWPDLFIAGGGISRKADKWVPLLENRTPVVPAALQNTAGIVGAAMASVADTTH
What is the function of this protein?
Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor (PubMed:8381043, PubMed:8703950).  Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in M. tuberculosis (PubMed:8703950).  GTP, UTP and CTP can replace ATP as phosphoryl donor (PubMed:8381043).
What are the official names of this protein?
Polyphosphate glucokinase, Poly(P) glucokinase, ATP-dependent glucokinase, Polyphosphate--glucose phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: Y068_METM5
Sequence: MGNYHVTLQASYIAKNVEDVEDAIGVAISQIGKLLNKGSLDYVDIDVGLTICPKCGEPIDCVLVVAKTAIVGILLSMKVFNAESPEHAVRIAKSSIGRALKDIPLEDVDVVEI
What are the official names of this protein?
UPF0212 protein MmarC5_0068.
What is the protein family that this protein belongs to?
Belongs to the UPF0212 family.
Protein: EIF3J_YARLI
Sequence: MASWDDEDFEVPAAATPAVPANWDDDEEEDVMDSWDAEEPTKAPGPKTTVAAPKKAQRQQIAKIEREMAAMKLKPEDASTKRDRQRQAELDSDMMNASELFGGTGGIADSAAKAEAAPAPAAPAAPMKLSDLAIFHPKEKKDFTNLKETLAPILTDLNKTSPLAYPDFAITFTKALAEPLKVEQLRKLISTLNAYQNEKIREEKAARGKKKKPGLAAASAKINDDKDTSTFNDNFDDFDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 30 kDa subunit, eIF-3 30 kDa.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_MARMM
Sequence: MSKRIAVLMGGLSPERDVSLVTGAACAKGLRDAGYEVVEIDAGRHLSQQLADADPDVVFNALHGEWGEDGLVQGVLEHFGKPYTHSGVLASALAMDKQKAKDVLRAAGIPCPEGIIANRFEAAKAHVMKPPYVAKPNAQGSSVGVHIVLEGANRPPAELGSTAWALGDEILIERYVPGRELTVAVMEDRALCVTEIKPNTTFYDYEAKYTAGGSDHILPAPISAEIAELAMDLAVRAHRALGCRGMTRSDFRYDSAADTPLWLLEINTQPGMTPTSLAPEQAQYCGIEFSDLVAWMAENASCRR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEM6B_MOUSE
Sequence: MWTPRVPPPRPALSFFLLLLLGVTYGLFPEEPPPLSVAPRDYLSHYPVFVGSGPGRLTAAEGAEDLNIQRVLRVNRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPICANYSMDTLQLLGDSISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVILAVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAVDVGAGPWGNQTIVFLGSEAGTVLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQLYSGCMKNCIGSQDPYCGWAPDGSCIFLRPGTSATFEQDVSGASTSGLGDCTGLLRASLSDDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFVGLRERRELARRKDKEAILAHGGSEAVLSVSRLGERRGTGPGGRGGAGGGPGGPPEALLAPLMQNGWTKAALLHGGPHDLDTGLLPTPEQTPLPQKRLPTPHPHAHALGSRAWDHSHALLSASASTSLLLLAPARASEQPQVPAEPGPESRLCAPRSCRASHPGDFPLTPHASPDRRRVVSAPTGPLDPSVGDGLPGPWSPPATSSLRRPGPHGPPTAALRRTHTFNSGEARPGGHRPRRHPPADSTHLLPCGTGERTAPPVP
What is the function of this protein?
Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance (PubMed:20484647).  May function through the PLXNA4 receptor expressed by mossy cell axons (PubMed:20484647).
What are the official names of this protein?
Semaphorin-6B, Semaphorin VIB, Sema VIB, Semaphorin-N, Sema N.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CG22_SCHPO
Sequence: MALYSISKPVGSKINKHSYQDENTLVGKQALSKGTEKTKLSTNFEINLPRRTVLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPSVETLQKDRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHNKPLEHKAFFQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition.  Interacts with the cdc2 protein kinase to form MPF.  Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription.  Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle.  G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.  Negatively regulates conjugation via interacting with cell cycle 'start' genes.  Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.
What are the official names of this protein?
G2/mitotic-specific cyclin cig2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: DRS7_PHYBI
Sequence: MASLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSNIKTAGKEAAKAALKAAGKAALGAVTDAVGEQ
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-B7, DRS-B7, Dermaseptin-gene related 1, Dermaseptin DRG1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCD_ECODH
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_ALKEH
Sequence: MRRLIPIAITGSLLWGAAVQAQGPTAAEREAYFAERQRALCGPPLVMPLDAVDTALRHRPETPATVDADAIYYDGAAGRYRFRGDVLMQRLDQRLRSEEVRYDHASGRVDLPFPFVYEEAGLALTGESGWLQLREDRGEVVAGEFMLDERNIRGRAERLELADAQRSRYEDVGYTTCRPGNEDWWLQARELELDREEGLGTARHAWFTFLNVPLFYTPWITFPIDDRRRTGLLAPGFATSDRHGTDITVPVYWNIAPNYDATLVPRWIERRGALLGGEFRYLQEAFSGELYGEYLPNDSLARDDRWLLGIDHRGRLPRGWRYDADINRASDGDYLRDFGSGLLETSSSHLQSRGRLRNRWNDWAVAAEVQHWQTLDDDLRNPYRREPRLTADYQGPFRAGQPRYRLNTEYTRFALPDTDADRPEGERMDIAPRVEWRLHRPWGYLTPAAALRHTQYRLDDPVPGADDRSPRRTVPTFSVDSGLFFDRPFDWDGRPMVQTLEPRVFYVYTPERRQDDLPVFDTSRRDFFFDGLFREDRFSGADRVGDADQVTVALTTRFVDLGGGREWLRASLGQIHYRRDRQVTLFPETDRAADRRSRSDYMAEMRSELPGGVLAQGEYRYNPYDSRSEQGAFRLGWHPRPDLLVGAGYRMRYGDEGRDVEQSDLAAVIPLGPRFSLIGRWLYSLADDNSLETVGGLEYRTCCWRVRAMGRRSFEGAGAEPDTSIMLQFEFTGLGQVDSGSTDFLQDSIYGYEGDRF
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: AROK_TOLAT
Sequence: MAEKRNIFLIGPMGAGKSTIGKYLSETLHMDLYDSDQEIERRTGADIAWVFDVEGEEGFRKREEQVISDLSELQGIVLATGGGAIKSPLTRNRLSARGIVVYLETPIEKQLARTQRDKRRPLLRTEEPPREVLTRLADEREPLYREIADYVVRTDELTAKQVATQIVELLGL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_BACAA
Sequence: MKERTIQPVNNGLNGNITIPGDKSISHRAVMFGAIAEGTTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAVLDVGNSGTTIRLMSGILANTPFLSCVQGDTSIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVKSAILLAGLRAEGVTAVTEPHISRDHTERMLEAFGVKVTREGKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAIIPNSKLVLENVGMNPTRTGIIDVLEKMGATFTVEPINEGASEPAANITIETSSLKGIEIGGDIIPRLIDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDRMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKTIIEDAEAVGVSYPTFFEELQKLAK
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTA_STRVG
Sequence: MTVLPDDGLSLAAEFPDATHEQWHRLVEGVVRKSGKDVSGTAAEEALSTTLEDGLTTRPLYTARDAAPDAGFPGFAPFVRGSVPEGNTPGGWDVRQRYASADPARTNEAVLTDLENGVTSLWLTLGSAGLPVTGLERALDGVYLDLVPVALDAGSEAATAARELLRLYEAAGVADDAVRGTLGADPLGHEARTGEKSTSFAAVAELARLCGERYPGLRALTVDALPYHEAGASAAQELGASLATGVEYLRALHDKGLGVEKAFAQLEFRFAATADQFLTIAKLRAARRLWARVAEVSGVPAAGAQRQHAVTSPVMMTRRDPWVNMLRTTVACLGAGVGGADAVTVLPFDHELGLPDAFARRIARNTSTILLEESHLARVIDPAGGSWYVERLTDELAHAAWDFFKEIERADGQVAALRSGLVGDRIAATWAERRKKLARRREPITGVSEFPLLTERPVEREPAPAAPPGGLPRVRRDEAYEELRGRSDAHLEATGARPKVFIAALGPAAAHTARATFAANLFMAGGVEPVHDPVSVDAETAAEAFAASGATVACLCSSDVLYAEQAEAVARALKSAGALRVFLAGRGEFADIDEYVFAGCDAVAVLTSTLDRMGVA
What is the function of this protein?
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.  This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis.  It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA.
What are the official names of this protein?
Methylmalonyl-CoA mutase small subunit, MCM-beta.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
Protein: ILVC_ECO55
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWTNDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNAQLRDVNEAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL14_ZYMMO
Sequence: MIQMQTNLDVADNSGAKRVQCIKVLGGSKRRTATVGDVIVVSVKEAAPRGRVKKGDVHRAVIVRTAKDIHRADGSVIRFDGNAAVLINKTSGEPIGTRIFGPVVRELRARNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RLMN_PARMW
Sequence: MLLGRSAAELESWAVAQGQKPFRGRQLHDWLYAKGARSLSEITVLPKAWRESLKEDGVEVGRLKEVHRSVAADATTKLLLSTDDGETIETVGIPTDQRLTVCVSSQVGCPMACRFCATGKGGLQRSLRTHEIVDQVLSVREVMDRRPSHIVFMGMGEPLLNSQAVLDAIRCLNDDLGIGQRRITVSTVGVPKTLPQLAELALATLGRAQFTLAVSLHAPNQALREELIPTAHAYPYEALLEDCRHYLAVTGRRVSFEYILLGGLNDAPEHAAELADRVGGFQSHVNLIAYNPIEEEEFQRPTRARIEGFQRVLERRGVAVSLRASRGLDQNAACGQLRRRRQGS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_ECOBW
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.