PharMolix/UniProtQA huggingface dataset:
Protein: MYD88_BOVIN
Sequence: MAEGVPRAGSALPAASLSSLPLAALNVRVRRRLSLFLNVRAPVAADWTVLAEAMDFEYLEIQQLEKYADPTSRLLDDWQRRPGASVGRLLELLAKLGRDDVLMELGPSIEEDCQKYILKQQQEASEKPLQVDSIDSSITRINDMAGITIRDDPLGQKPECFDAFICYCPSDIEFVHEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDEYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKPMKKEFPSILRFITVCDYTNPCTQNWFWTRLAKALSMP
What is the function of this protein?
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.  Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Increases IL-8 transcription.  Involved in IL-18-mediated signaling pathway.  Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17936907, PubMed:18760477).  Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity).  MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
What are the official names of this protein?
Myeloid differentiation primary response protein MyD88.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CNP2_CAEEL
Sequence: MNRGYDSYNRSRSTSSRPLDREPYHAVSELYTKEITHTPIGPASDLPPEILDILKENPRATPQYTPPLIRHRENTWTPENYPIVRVPSAQFTDVMTELYDYHEVEKYTHRSVTPDYEPLRKEPELKEQKLPTYQVIPPTPEKNTPRHQHHSGITLSPSDSSRTLGALPKKPPMYEEYLQMQKKDENRNIPRQVSSADSQRTIRNNNELSHLRHIDSSSSSEASEPAKDLDDRERYVYTHDVYVDSTTGRPFTPGREDVREKKNCDKLKINVYFKPPHPPVEITYKLDEIEIEKNENIVVTKLRPSRSDTILSRSVSTSPSSVTDNIPKTSTSRIPSSENPKTMEHTTTSRRFPTQTSILRKEHEIVQVPLHRSQSLRQSRISEHSKRSLGKTTSTVSTERPIPIHVVEETSSIDMDVVFPKMPHHQTVTNVRVPSSRGSAISRAHSEHRRSIDRSEPRHHHRHHVHSETPELPYTRGISKTPSVREYNVKREGQRSPSRSHRSERSPSEVRIPVTTTHTRPIAKRQSPEELDYGRFADKSQQNRFPGDHQAREEDLPYTRGISKTPSNQDSRSERTPCSDIHIPYNNPEKERAYQQSERSSYRSHKSVTPSEKSLPRNSETPELHYTRGISKTPSDRVEKSRYLSRGVSTPHTPSEVHIPYNNPEKERAYQQSHRPSSPKRRPSGRTNSPNKSSSSSKARPSAAPLEEIVHIKERYERDETIRRFFPTTTAV
What are the official names of this protein?
Calcineurin-interacting protein 2, Calcineurin binding protein 2.
Protein: YWNF_BACSU
Sequence: MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAFSLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRIKKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY
What are the official names of this protein?
Uncharacterized protein YwnF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YP092_YEAST
Sequence: MDFIEGEKDQRQKCDTAKQVNCEKYLQASHYGLLMLLFSCCSALRCVQNPFSWLLYKRDLRRKLKWEKTEKCAIPIRCKNERSKGKRTKSYLKGYIGCKIS
What are the official names of this protein?
Putative uncharacterized protein YPR092W.
Protein: PTA_BUCBP
Sequence: MTRTIMLVPIGKNIGLTTISLSVISAMKRCKFNVKFLKSAIEYSNTNYNIDDTSLILKDTQSLSYINPLIVDFINQFSLKQIKQRIVDYILSKVYAKKEKYDIFLIEGFDTKSHTYVLSNDINYYISKSINVEIVFVCAVDRSSQLDINNIVYIINNVFKKNKNINIRGVIINELCQKVRNDYGNVNLFDMFKSSVKKINFGDVKYDFLFQKNGIEVLGCVPWIHKLMEPSVKILCDKYLGANIIYDRCMNSQYIKTFIIYDTNEDIKNAKKFHRSLLIIPAISNDKIKEICVQINKNKILISAILLTNFLNVHDKCTDFIDQLKIANCTICSTPNDVFTVVSLLHKFNFKLDNKNYQLNIIENDMSRHINLDWIRSLKHSYQYNSICLPSLFIYNLKHLAKKFMKNILLPEGCELRIIKAASICSKNDIAYCTLLGNPKKIKNIAESNNIVLNSNIEIIDPKLIRKNYVERLCHLRRHHGITLAHANELVKDNSILSTLILESKKVDGLVSGSIGTTSSIILPALQLIKTSPGSSLISSVFFMLLSDYVTLYADCAVNINPDATQLAEIAIQSSNTARLFGIFPKVAMLSYATGCSGFGDTVDKVKEATRIVQERSPNLIVDGPIQYDAAINRSVAKLKCPHSLVAGNATVFIFPDLNSGNITYKAVQRSANILSIGPILQGINQPVNDLSRGSSVQDIVYTIAVTVLQSSLSH
What is the function of this protein?
Involved in acetate metabolism.
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_BREBN
Sequence: MKVIIGLGNPGKKYEDTRHNAGFMAIDKISDKWGIPVTQNKFRALVGEGRIEGEKVLLVKPQTYMNLSGESVAEVLKFYKLIPDDLVVIYDDLDLPTGHLRLREKGSAGGHNGIKSMIQHLGTQEFKRIKVGISRPEPGRSVSDYVLNTFPVAERADIQEAVSLAADACAMWTRESFLKVMNHFNSLKK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREF_DECAR
Sequence: MKTCLQLARLLQLASPTLPVGAYTYSQGLEWAVESGVIRDEASAGRWIADLMHHGIGCYEAPMVAALMTAWSAGDVDEIECLNAEFLASRESAELRAETVQMGFSMRRLLRDLRDDTLAAVATLVETQAEVAFPTVWSGIAAAWQIEPEAAVTAYLWSWAENQVMAALKAVPLGQASGQRLLAELGSRIPEAAANANTLPKSRWSNFTPAFAIACARHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_MARN8
Sequence: MSRVANNPVVLPSGVEVKLNGQEINVKGSKGALQFTIHQAVEVKQEENVLRFAARDGAKQSRALAGTTRALVNNMVTGVSTGWERKLQLTGVGYRAQAQGKKLNLTLGFSHPVEYELPEGVTAETPSNTEVVIRGIDKQQVGQVAAEIRAFRPPEPYKGKGVRYADEQVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: KCY_CLOAB
Sequence: MRLNIAIDGPAGAGKSTIAKLVAKKFRLMYINTGAMYRAVTLMAMRQNIRANDVKKLCDLIESLSMHFENDKLIVNGEDVSEEILLPKTSQNVSDYASVLEVREKLVYLQKKMAGRYDVVMDGRDIGTVVLNDAPFKFYLTATPEERAKRRYKELSAKNIKVCYDDILNDIIRRDYIDSNREVNPLTKAYDAVEIDSSNMCIEEVVDYIVQYISKKI
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELW_MACMU
Sequence: MALAVRVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAALAQG
What is the function of this protein?
Plays a role as a glutathione (GSH)-dependent antioxidant.  May be involved in a redox-related process.  May play a role in the myopathies of selenium deficiency (By similarity).
What are the official names of this protein?
Selenoprotein W, SelW.
What is the protein family that this protein belongs to?
Belongs to the SelWTH family. Selenoprotein W subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_SHEPC
Sequence: MKTFTATPETVTRDWFVVDADGKTLGRIATEIATRLRGKHKPEYTPHVDTGDYIIVINAEKVTVTGNKAKGKTYYSHSGFPGGIKQISFEKLQAHKPEMIIEKAVKGMLPKGPLGRAMFRKLKVYAGAEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SURE_ALKEH
Sequence: MMHILVSNDDGYQAPGILALAEALSEMARVTVVAPERDRSGASNSLTLDYPLRVHGTGPHRYRVEGTPTDCVHLAITGLLSEEPDMVVSGINAGANMGDDVLYSGTVAAATEGRFLGLPAIAISLNAFEPRHLATAARVAQLIVQRLSRDPLPSDTILNINVPDLPWHEVQGWEATRLGRRHRAEPVVRDEDPRGRAIYWIGPPGSEEDAGPGTDFYAVRNGYVSVTPIQVDLTRYTALDQVAGWVSGLGRPAEEGH
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRK_LYSSC
Sequence: MIRQEKMRVVSQKQIATNIFELTLHGELVQDMTPGQFVHVKVSDSLEPLLRRPISIANIDKDNNEFTMIYRAEGRGTKVLATNREGQQVNVLGPIGNGFPVDAVKEGGTALLVGGGIGVPPLHELSKQLNARGVKTIHVLGFQTEDVCFYEEEFSALGETHYVTVDGSKGTKGFVTNVLESRAPEFDVFYSCGPLPMLKALEGFYPEKEGYLSFEERMGCGIGACFACVCKTTDQIAKDYVKVCSDGPVFPKGTVAL
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: TSAD_ALISL
Sequence: MRILGIETSCDETGVAIYDDEKGLLAHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIQAALNDAGMTKDDIDGIAYTAGPGLVGALLVGSTIGRSIAYAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTLMVEVKGIGDYQILGESVDDAAGEAFDKTAKLMGLDYPGGPRLSKLAEAGVKGRFKFPRPMTDRPGLDFSFSGLKTFAANTIRANDDDEQTRADIAFAFQEAVADTLAIKCRRALKQTGMKRLVMAGGVSANTYLRQELEAMMKKIGGEVFYPRTEFCTDNGAMIAYAGMQRLKNGETTDLAVQAKPRWPIDQLAPIK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_PEDPA
Sequence: MPELPEVETVRRGLAALVEGKIVTNVVVRYSKMVSPKAEIFAEELEGKKILNVRRRGKYLLIDFSGDYTMVSHLRMEGKYSVVDRREEYGKHDHVIFELDDGKDLRYNDTRKFGRMNLVPTGEELQVGGLKTIGPEPTPETLTLEYLTHQLRNRKRGMKSFLLDQSMIAGLGNIYADEVLWLSKIHPQQISNTLTDEEIAILRESIFEELQLAIEAKGTTVFSYLNADGHAGSFQNQLHVYHRQGLPCQRCGTPIERIKVAQRGTHFCPHCQVLR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DNAK_PROA2
Sequence: MGKIIGIDLGTTNSCVAVMQGTQPTVIENSEGYRTTPSMVAFTKNGERLIGHAAKRQAITNAKNTVFSIKRFMGRKFDEVPNEKKIAPYKVVNINGEARVEIDDKNYSPQEISAMILQKMKQTAEDFLGEKVTEAVITVPAYFNDAQRQATKDAGKIAGLEVKRIINEPTAAALAYGLDKKKENEKVAVFDLGGGTFDISILELGDGVFEVKSTDGDTHLGGDDFDQTIIDFLADEFKKQEGIDLRTDAIALQRLKEAAEKAKIELSSRTDTEINLPFITATQEGPKHLVVNLTRAKFEALASTLFDNIMAPCKRAIKNAKVNISEIDEVVLVGGSTRIPKVQELVKELFKREPNKSVNPDEVVAVGAAIQGGVLTGEVSDVLLLDVTPLSLGIETLGGVMTKLIEANTTIPTKKQEVFSTAADNQTSVEVHVLQGERPMASDNKTLGRFHLGDIPPAPRGMPQVEVAFDIDANGILHVSAKDKATGKEQSIRIEAGGKLNDAEIEKMKNDAKAHAEEDAKRKEEVETKNAADSLIFSTEKQLQELGDKIPADKKAPLESALDRLKEAHKSGSADAIKPAMDEVNTIWNDIASQLYQAADAPGSGTPNPEAESGKQESSGKTDGQVDAEYEVIDGNDKDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL15_BRUPA
Sequence: MGAYRYMQELWRKKKSETMRYLLRIRCWQYRQLTAIHRVSRPTRPEKARRLGYLSNEGYIIYRVRVLRGGR
What are the official names of this protein?
60S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: PLSB_SHIFL
Sequence: MTFCYPCRAFALLTRGFTSFMSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRFYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NOF_DROME
Sequence: MPAKPQVDGHTLVDAFCCANIFTETGALKPRSDKVWMDISNQLKGAISAKTLNFYARINRNNMITVVKERCGIQQLDTSANLTLNSTFPDDDPEFQITEASKNGPLPILYFNLELDLELWRSIAPKKDQKTEKLQPNWTDTMAKLIYKKVPLPCAFNFRKAKLSDKVDNIWLRIEGYCNDCSSILKGHCLVKPDEQCGIMISVSVPDTRGIPHNKKRRCTGSRRLEIGNELILKKAALWRKEATDNMNDDDPEPSYIPNLPTLRKLREEATNRHLGITKDRDPVSSLYLKKYEGELAGCILDIGLDEFFCIYCTGTQVKTYASRIKTIRKISIDATGSVVLPIQKPNGDSSYVFLYQIVMEGDDSIFPVFQMLSAKHDTASIQFWLSRFISKSGHFPLEVVSDFSLALLNGISLSFNECRIATYIKKCFHSLLMEERTDLPPCYIRLDIAHLIKMICRKNVFKSKLPNLKDFYTRCIGLATTCETKDSFAELIKSVLIVALSQSSGEDEKGDILSSYRNEKYLLARIATFTAPDHKETIEDNCIPEDQEEIDEDVTDFISNIKIAAEEEALNCNSVNCRPNPYFLPELMPPLIKLCKYFVLWTNVMKEKFCSKYDVGSSALVEAYFKDLKNTDMSIFHRPVRADKFVVQHIRCIEAVCKLERAAMKRKTVKTPSFIKENAPKKMCSKETKGFLEEILEESEVEYLLQEENWKVKNKTIKPTEGNDAEDNDTDDENKEMDLSEQPKEKPRGKYLKKCPNVELLYNRPHRRKQDEILHNGGSMGPVWIGKQLLQFKNTCPFDSLVEILSTAYIDNFYYKSLLDDFYTDNLTIELVKKYAVEGVSSSLYCDRGLVLKSFFDEKHQIIKCDANIGSFIEKALNGVPSASSHRTHIKNNHDCRNQKYIHHRLEVIDVEKVGHLDVQEVVIPFIDEFFARTDGECKICGGQQILERQPGPHVILDIEFAMDAFHQIHHNGLPGTTTLLQVPEEILIQEKKYILSGAIEYVPAMGGEIGHYIAYCRRVIGSWEVHNDMCRQWKKFSALNTKMTLHILIYTRKN
What is the function of this protein?
May be involved in the transposition of NOF-FB and other FB elements.
What are the official names of this protein?
120.7 kDa protein in NOF-FB transposable element.
What are the subcellular locations of this protein?
Nucleus.
Protein: GHRB_SHISS
Sequence: MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLLGSNENVDAALLEKMPKLHATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRYGMAACAVDNLIDALQGKVEKNCVNPHVAD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMM91_MOUSE
Sequence: MDNSSIQELQQPLLPSITCDLLAPRSEKPELGTPFPETAFAESPRGWQLLLPPLPSVSAGLGEPETPDFEDTLSSDSDSDDDGGDRLSPLLPHDHLGLAVFSVLCCFWPVGIAAFCLAHKTNKAWAKGDVQGAGAASRRAFLLGVLAVGLGLCTYAAALVTLAAYLASRDPP
What are the official names of this protein?
Transmembrane protein 91, Dispanin subfamily C member 3, DSPC3, Synapse differentiation-induced protein 3.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TCLB1_MOUSE
Sequence: MAAAAFDPLGPLPVYLVSVRLGIYEDEHHRVWIVANVETSHSSHGNRRRTHVTVHLWKLIPQQVIPFNPLNYDFLPTTWKLESRNIYWATDGTHWRLLDHSQLGDTEQLILMLVLG
What are the official names of this protein?
Protein TCL1B1.
What is the protein family that this protein belongs to?
Belongs to the TCL1 family.
Protein: POSTN_MOUSE
Sequence: MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEPKIKVIQGSLQPIIKTEGPAMTKIQIEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKQTREERIITGPEIKYTRISTGGGETGETLQKFLQKEVSKVTKFIEGGDGHLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ
What is the function of this protein?
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:10404027).  Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (PubMed:20181949).
What are the official names of this protein?
Periostin, PN, Osteoblast-specific factor 2, OSF-2.
What are the subcellular locations of this protein?
Golgi apparatus. Secreted. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi (PubMed:20181949).
Protein: YEGS_SHIFL
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARFVEEARKLGVATVIAGGGDGTINEVCTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_EDWI9
Sequence: MRILGIETSCDETGIAIYDDEKGILANQLYSQIKLHADYGGVVPELASRDHVRKTVPLIQAALREADLTPADLDGVAYTAGPGLVGALLVGATVGRSLAFAWGVPAVPVHHMEGHLLAPMLEENPPAFPFVALLVSGGHTQLISVTGIGEYRLLGESIDDAAGEAFDKTAKLLGLDYPGGPVLSRMAQQGVPGRFVFPRPMTDRPGLDLSFSGLKTFAANTIHANGDDAQTRADIARAFEDAVVDTLAIKCRRALDQTGFQRLVMAGGVSANRALRGRLAQMMQQRGGAVFYARPEFCTDNGAMIAYAGMVRLKSGVDADLSISVRPRWPLAELPPVAARS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV08
Sequence: MARARRVKRDSVTHIYQTCKQAGTCPPDVINKVEQTTVADNILKYGSAGVFFGGLGIGTGRGTGGVTGYTPLSEGPGIRVGNTPTVVRPSLVPEAVGPMDILPIDTIDPVEPSVSSVVPLTESSGADLLPGEVETIAEIHPVPEGPTIDSPVVTTSKGSSAILEVAPEPTPPTRVRVSRTQYHNPSFQIITDSTPTQGESSLADHILVTSGSGGQTIGSDITDVIELQEFPSRYSFEIDEPTPPRQSSTPIERPQVVGRRRGISLTNRRLIQQVAVEDPLFLSKPSKLVRFSFDNPVFEEEVTNIFEQDVDMVEEPPDRDFLDVRQLGRPQYSTTPAGYVRVSRLGTRGTIRTRSGAQIGSQVHFYRDLSSINTEDPIELQLLGQHSGDSTIVQGPVESTFVNVDISENPLSESIQAFSDDLLLDETVEDFSGSQLVIGNRRSTTSYTVPRFETTRSGSYYVQDTKGYYVAYPESRNNEEIIYPTPDLPVVIIHTHDNSGDFFLHPSLRRRKRKRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: LEU1_PSECP
Sequence: MRNAQKSSGMPFHRYTPFQDQITVEMPDRTWPDKVITKAPRWCAVDLRDGNQALIDPMSPARKMKMFDLLVRMGYKEIEVGFPSASQTDFDFVRQLIEGNHIPDDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQGARLCRKYEETLADTHITYEYSPESFTGTELEYAVRVCNAVADVFEASADRQVIINLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVDLVTLGLNLFVQGIDPMIDFSDIDDVRRTVEYCNQLPVPERSPYGGDLVFTAFSGSHQDAIKKGFEALERDAAAAGKDVADVTWQVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKNEHSLDLPRRAQIEFSGVIQRRTDTVGGEVSGAQLWQIFQDEYLPSGKADGQWGRYSLGSVKTETDDDGGMTLHASLTVDGAQVSRTGTGNGPIAALLNILTQDGVDVRVLDYSEHALSEGGNAMAAAYVECAVGERVLWGVGIDANTSMSSLKAVISAVNRAIRDAQS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: TILS_PARD8
Sequence: MIHTIRLYIEKYRLLSEDRPVLVGLSGGADSVALLGVLVRLGYPCIALHCNFHLRGEESDRDEAFACEFAESLEVPFHKIDFDTISYAGERHLSIEMAARELRYAWFEEMRERLGGQATAVAHHRDDNVETVLMNLIRGTGIRGMSGIRPRNGFIVRPLLCVSREDILAWLADQGYAYMVDSTNLSDAYTRNFIRLNVLPLLEEINPSARNTIARSAEHLSAAETIYIYVLEQARKEVVVSDDRLSIGALMRFPAPETILYELLKEYGFTRLVSDDIFAALTKEPGKLFYSSTHRLLKDRDYLWITSLEKKEKRTFVLDPEKGINHEPIELSFQKLVITIDFPIEKNKRIAYLDYDKLDFPLTLRTWKEGDWFIPFGMKGRKKLSDYFSDHKFSRIEKERTWLLCSGDAIVWVVGERTDNRFRIDESTKRVLIVNFLG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.