PharMolix/UniProtQA huggingface dataset:
Protein: RBL_CROS5
Sequence: MAQATKSGFNAGVQDYRLTYYTPDYTPKDTDLLACFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDNLTDLDRYKGRCYDIEPVPNEDNQYFCFIAYPLDLFEEGSVTNVLTSLVGNVFGFKALRALRLEDIRFPVALIKTFQGPPHGITVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFMRWRDRFLFVQEAIEKAQAETNEVKGHYLNVTAGTCEEMMKRAEFAKEIGTPIVMHDFLTGGFTANTTLAKFCRDNGILLHIHRAMHAVIDRQKNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGERGITMGFVDLMREDYVEEDRSRGIFFTQDYASMPGTMPVASGGIHVWHMPALVEIFGDDSCLQFGGGTLGHPWGNAPGATANRVALEACIQARNEGRNLAREGNDVIREACKWSPELAAACELWKEITFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Carboxysome.
Protein: LDH_BIFA0
Sequence: MVNSPIKPTKLAIVGAGAVGSTLAFAAAERGIAREIALQDIAKERVEAEVLDMQHGSSFFPTVSIEGSDDPEVCRDADMVVITAGARQKPGQSRLDLAGATINIMKSIIPNMLKVAPNAIYMLITNPVDIVTHVAMKLSGLPASRMFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPLWASATIGGVPMCDWQALPGHEPLDAEARERIHQEVKNAAYKIINGKGATNYAISMSGVDIIEAILKDSNRILPVSSLLSDFHGISDVCMSVPTLLNRNGVNSRINTPVSDRELAALKRSAETLRETAAQFGF
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPE_RHOCA
Sequence: MALRDERVTLAHGGGGKAMRDLIEEVFTSVFQPPGMEDQARLTEAALAEPGARLAFTTDSYVVTPVEFPGGDIGKIAVCGTVNDLAVGGARPLWLSAAFILEEGTEVALLRRIVATMAREAEAAGVRIVTGDTKVVGRGACDGVFVTTSGVGVIPPGREMAAGRVRPGDVAIVNGVLGDHGATILAARGDLALTSDIESDCAALGHLMADVIAAAPGIRAARDLTRGGLASALNEIAQTAGCGLVIEETALPLRPEVVGLCEILGLDPLYLANEGRLVVFVPEAEAAAALAAMRARPEGAGACVVGRAVAEHAGQVRMRTAFGGARIVDMLVGEQLPRIC
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases.  HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group.
What are the official names of this protein?
Carbamoyl dehydratase HypE, Hydrogenase maturation factor HypE.
What is the protein family that this protein belongs to?
Belongs to the HypE family.
Protein: S38AA_HUMAN
Sequence: MTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGPPEES
What is the function of this protein?
Putative sodium-dependent amino acid/proton antiporter.
What are the official names of this protein?
Putative sodium-coupled neutral amino acid transporter 10, Solute carrier family 38 member 10.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YICC_ECOLI
Sequence: MIRSMTAYARREIKGEWGSATWEMRSVNQRYLETYFRLPEQFRSLEPVVRERIRSRLTRGKVECTLRYEPDVSAQGELILNEKLAKQLVTAANWVKMQSDEGEINPVDILRWPGVMAAQEQDLDAIAAEILAALDGTLDDFIVARETEGQALKALIEQRLEGVTAEVVKVRSHMPEILQWQRERLVAKLEDAQVQLENNRLEQELVLLAQRIDVAEELDRLEAHVKETYNILKKKEAVGRRLDFMMQEFNRESNTLASKSINAEVTNSAIELKVLIEQMREQIQNIE
What are the official names of this protein?
UPF0701 protein YicC.
What is the protein family that this protein belongs to?
Belongs to the UPF0701 family.
Protein: RPO10_METM5
Sequence: MIFPIRCFSCGAVISEVYEEYRTRLKNGENPEEILNDLEVKKYCCRRMFASHRLDNDRELFDDIVEYK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOM1_MOUSE
Sequence: MPRNVPEVNGVYRHGACELWCRAMAHALLKRSGVRRGLGGREGPLKRLRLAVEDFVRTTSESEACESRSAVARSRPGGRKSRKELRKEKRHLRKARRLQRTVGSGSGDQGGNVGLNDGPETRRPPTEVRPTPAKATATPAKASAPSTNTKASAAQPKAKAKGAPGKPGPATATARKRALLAANEEEDREIRKLERCLGLHKRKKKGDGSSVPLSFARDGLDYILGALECGSGGGLYESSEEEEEEKLETGQTVLESDLESNSKESEEDPDWQVLQEDQEDVNSKRRGEAESGTRGNKGTKKVRFAEVVEKSRSSSEDDIEQQESHSVESGEKYIPPRLRNEEVIDVHKKEELDRLKKHVKGLINRLSEPNMASISGQLEELYMAHSRKDMNDTLTTALMDACVTASAMPSRLMMEHVFLVSILHHTVGIEVGACFLEAVVKKFDAIYRDGGEGKELDNLFTMIAHLYNFHVVQSILIFDILKKLVGTFTEKDIELILLMLKNVGFALRKDDALSLKELITEAQTQASGAGNKFQDQNRVRFMLETMLALKNNDLRKIPGYNPEPVEKLKKLQRTLVRNAGSGSETRLRISWDGILNAEQTGRWWIVGSAWSGTPMIDNSHHIQLQKPLAGMASSKMLELARKQRMNTDVRRIIFCTLMTSEDFLDAFEKLLKLGLKDQQEREIVHILMDCCLQEKTYNPFYAFLASKFCDYERRFQMTFQFSIWDKFRDLENLPDTKFSNLVHLLAHLLRTKSLPLSVLKVVEFSELDKPRVHFLRRVLTALLMETEDDDLAVIFSRVSDNPKLGMLREGLKLFIGHFLLKHTQAHQSAEEASLLREKAGLASKSLQGKAILRM
What is the function of this protein?
Plays a role in targeting PPP1CA to the nucleolus.
What are the official names of this protein?
Nucleolar MIF4G domain-containing protein 1, SGD1 homolog.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RDRP_INCJJ
Sequence: MEINPYLMFLNNDVTSLISTTYPYTGPPPMSHGSSTKYTLETIKRTYDYSRTSVEKTSKVFNIPRRKFCNCLEDKDDLVKPTGNVDISSLLGLAEMMEKRMGEGFFKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATALQLTVDAIKETEGPFKGTTMLEYCNKMIEMLDWKEVKFRKVKTMVRREKDKRSGKEIKTKVPVMGIDSIKHDEFLIRALTINTMAKDGERGKLQRRAIATPGMIVRPFSKIVETVAQKICEKLKESGLPVGGNEKKAKLKTTVTSLNARMNSDQFAVNITGDNSKWNECQQPEAYLALLAYITKDSSDLMKDLCSVAPVLFCNKFVKLGQGIRLSNKRKTKEVIIKAEKMGKYKNLMREEYKNLFEPLEKYIQKDVCFLPGGMLMGMFNMLSTVLGVSTLCYMDEELKAKGCFWTGLQSSDDFVLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKSYGSLPELFEFTSMFFDGEFVSNLAMELPAFTTAGVNEGVDFTAAMSIIKTNMINNSLSPSTALMALRICLQEFRATYRVHPWDSKVKGGRMKIINEFIKTIESKDGLLIADGGKLMNNISTLHIPEEVLKFEKMDEQYRNRVFNPKNPFTNFDKTIDIFRAHGPIRVEENEAVVSTHSFRTRANRTLLNTDMRAMMAEEKRYQMVCDIFKSVFESADINPPIGAMSIGEAIEEKLLERAKMKRDIGAIEDSEYEEIKDIIRDAKKARIESR
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: PKSA_BACSU
Sequence: MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLGALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAVRDLLPKEKVLQILLEMVPTNEETIREMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKDIEAERLYALVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP
What is the function of this protein?
Transcriptional regulation of the polyketide synthase operon.
What are the official names of this protein?
HTH-type transcriptional regulator PksA.
Protein: ATPB_ANOFW
Sequence: MAKGRVIQVMGPVVDVKFEDGHLPAIYNALKIKHKARNEKEVDIDLTLEVALHLGDDTVRTIAMSTTDGLVRGMEVIDTGAPISVPVGEVTLGRVFNVLGEPIDLGEEIPADARRDAIHRPAPKFEQLSTQVEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMKDSGVINKTAMVFGQMNEPPGARMRVALTGLTMAEYFRDEQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTAVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERKLSEMGIYPAVDPLASTSRALSPEIVGEEHYQVARKVQQTLQRYKELQDIIAILGMDELSEEDKLVVHRARRIQFFLSQNFHVAEQFTGQPGSYVPVKETVRGFKEILEGKYDHLPEDAFRLVGRIEEVIEKARKMGVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL11_ACIAD
Sequence: MAKKIDGYIKLQVPAGKANPSPPIGPALGQRGVNIMAFCKEFNAATQKLEVGLPIPVVITVYNDKSFTFIMKTPPASILLKKAAGIQKGSSVPNKTKVGKLTRAQLEEIATTKEPDLTGADLDARVRTIAGSARSMGLEVEL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MATK_LIRTU
Sequence: MEELQGYLEIDRSRQQHFLYPLLFQEYIYALAHDHGLNGSIFYEPMENLGYDNKSSSLIVKRLITRMHQQNHLIISVNDSNENGFVGHNKSFYSQMVSEGFAVIMEIPFSLRLVSSLEEKEIAKSHNLRSIHSIFPFFEDKLSHLNHVSDILIPHPIHLEILVQTLHCWIQDAPSLHLLRFFLHEYRNSNSLITPKKSISLFSKENQRFFLFLYNSHVYECESVLVFLRKQSSHLRSTSSGTFLERTHFYGKIEHLVVVLRNDFQKTLWLFKDPFMHYVRYQGKYILASKGTHLLMKKWKSHLVNFWQCHFYLWSRPDRIHINQLYNHSFYFLGYLSSVRLNTSAVRIQMLENSFLIDTSINKFETLVPIISLIGSVAKAKFCNVSGHPISKSVRADSSDSDIINRFGRIYRNLSHYHSGSSKKQTLYRIKYILRLSCARTLARKHKSTVRAFLKRLGSEFLEEFLTEEEQVLSLIFQRNSFPSYRSHRERIWYLDIIRINDLANHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RK32_NYMAL
Sequence: MAVPKKRTSISKKHIRRNFWKRKGYWAAVKAFSLAKSISTGYSKGFFVRQKK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_ECO81
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNPDAITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGSSMRVALELVKEGRAQACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAIMGSVLAEEVVEIPNPRVALLNIGEEEVKGLDSIRDASAVLKTIPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFELLDGGKSGTLR
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS13_CRIGR
Sequence: MGRMHAPGKGLSQSALPYRRSVPTWLKLASDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SYK_LEGPH
Sequence: MSEEHVHLDESEVYHIRKQKLAELRTGGFNFPNTFRREHLADALLKQYSETEKQTLEQKHVKVSVAGRIVLRRIMGKASFFHIQDVSGRIQVYLRSNDLPDIYEQFKHWDLGDIVGVQGELFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKYRKRYVDLIANEDSRKTFLIRSHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRLVVGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLATRQIEYQGQVIDFNKPFERLSVKEAILKYHPDIKAQQLETVEGCRTLLNDLGLPYKETDGLGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTNPEVTDRFEFFIAGREIANGFSELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFTNSQSIRDVILFPHLRQ
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_SULDN
Sequence: MIIAANLKTNLTREKTAKYIKEVESFLNQHNISQEVFVFPAISNLISSSANVVVGAQNAYPTQNGAFTGEIGNEQLEEFGIKTILIGHSERRHVIGETQDSLIVKFNFYKNLGFKIIYCVGEPLHIREMGHEKMMEYISAQYVGIDAAYENLIIAYEPVWAIGTGLTPTLEDIKMIHKELKAKSTAPLLYGGSVKVTNVEEVLALDGVDGVLVGSAALYVEHFCTMCEYAQNIDKKNKKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_ECO81
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ASQO_EMENI
Sequence: MQIVYLFSSVLLTAALAHENGKVAYPFRLFNGTSSVEEISQQDQMDAPKIMPHVNATTFEWWYFDAVSTTSQNESLTVMFENMGPEGLGAPYPGGPLAVQISGSFSNGTAFTIITAATKGAVLEWGGGGVRGEWRGAGSSFAGKDHREYTVSIANPGIGVYGTMTLRSVSPPRYPCDVKERRASEQLIPNMYLANSQPDAIVEVDFNINESTLKFSGIGYHDLSWGSAPLESSVHSWYWGHGRLGRYSLVWFDVMGRDGKEYFSAWITEAGNVILCGCEPDSVLVRPWGENSGFPPGRGTPAPSGYSLRYDLGQNQIFIANFTREVNIIDNDFTKHIIGLFSGGFEGGEQYEGRAMADQFQFGDL
What is the function of this protein?
Quinolone epoxide rearrangement protein; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934, PubMed:28114276, PubMed:30026518).  Within the pathway, asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (PubMed:28114276, PubMed:30026518).  The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin.  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Quinolone epoxide rearrangement protein asqO, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqO, Aspoquinolone biosynthesis protein O.
What is the protein family that this protein belongs to?
Belongs to the quinolone epoxide rearrangement protein penF family.
Protein: PROY_ECOL6
Sequence: MESKNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGIAAYIIMRALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMIVAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTAGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKIFSKTSRRGIPWVTVLVMTTALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVATTIGGLIFLLFIIGLIGYHPDTRISLYVGFAWIVVLLIGWMFKRRHDRQLAENQ
What is the function of this protein?
Permease that is involved in the transport across the cytoplasmic membrane of proline.
What are the official names of this protein?
Proline-specific permease ProY.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS14Z_KOSOT
Sequence: MAKKSMVAKWKRGSKYKVRKYNRCHICGRPRAVYREFGLCRVCFRKLASEGKLPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: GLPK_CERS5
Sequence: MSHILAIDQGTTSSRAMVFDASLSLKSVAQEEFPQIYPRPGWVEHDPTDLWSSVAATARAAVERAEIDGSLAAIGITNQRETVVIWERATGHPIHNAIVWQDRRTADLCQSLAEAGQEPMITERTGLLLDPYFSATKVKWLLDHVEGARARARRGELLFGTVDSYLIWKLTGGRSHVTDATNAARTMLFDIRRGEWDAEICGLLDIPMEMLPEVKDCAAPFGMTRADLFGREIPILGVAGDQQAATCGQACFRPGMMKSTYGTGCFALLNTGAERVTSRSRLLTTIAYQLGGQRTYALEGSIFIAGAVVQWLRDGLKIIREAGETHGLATASDAAQDLVIVPAFTGLGAPWWKPDSRGAVFGLTRNSGPAEFARAALESVGYQTRDLLEAMRADWAAGAEGVLRVDGGMTASDWSMQFLADIIGAPVDRPVVRETTALGAAWLAGMQAGLCPGPEEFAAGWALERRFEPRMEAATRDAKYARWGRAVRAVMAV
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: STPA_ECOLI
Sequence: MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKISTWLELMKADGINPEELLGNSSAAAPRAGKKRQPRPAKYKFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI
What is the function of this protein?
(Microbial infection) Originally isolated as a suppressor of a splicing defect of the thymidylate synthase (td) gene from bacteriophage T4 (PubMed:1480493).  Acts as an RNA chaperone, accelerating splicing of viral pre-mRNA.  Binds preferentially to unstructured over structured RNA; does not have a detectable high-affinity RNA-binding site in the pre-mRNA.  There do not seem to be any specific RNA targets in transcribed E. coli DNA (PubMed:17267410).
What are the official names of this protein?
DNA-binding protein StpA, H-NS homolog StpA.
What is the protein family that this protein belongs to?
Belongs to the histone-like protein H-NS family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Scattered throughout the nucleoid (PubMed:21903814).
Protein: IHFB_MANHA
Sequence: MTKSELIESLASKNPSLPIKMVEHCVKELLEQLTATLEEGERIEVRGFGSFSLHYRQPRLGRNPKTGESVLLGAKYVPHFKAGKDLKERVDLL
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL32_METVS
Sequence: MSEFKRLMRLKLKMKQKRPEFKRQDSHRFQRIGTMWRRPTGHHSGQRIQVTYRLSPVKIGFRGPALVRGLHPSGLEDIIVNNVKQLAALNPKTQGARIASAVGTRKRIEIVKKANELGIRVFNVSKQKQGEFLSL
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: TRPA_STAAN
Sequence: MTKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIRYLQSIQQTLNN
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: BR2E_PULPI
Sequence: GFLDSFKNAMIGVAKSVGKTALSTLACKIDKSC
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium S. aureus ATCC 25923 (MIC=36 uM) and the Gram-negative bacterium E. coli ATCC 25726 (MIC=18 uM).
What are the official names of this protein?
Brevinin-2PTe.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.