PharMolix/UniProtQA huggingface dataset:
Protein: NB1_MYCTU
Sequence: MTRDLAPALQALSPLLGSWAGRGAGKYPTIRPFEYLEEVVFAHVGKPFLTYTQQTRAVADGKPLHSETGYLRVCRPGCVELVLAHPSGITEIEVGTYSVTGDVIELELSTRADGSIGLAPTAKEVTALDRSYRIDGDELSYSLQMRAVGQPLQDHLAAVLHRQR
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  In M. tuberculosis, could be part of the pool of proteins required to scavenge RNS and ROS produced by the host during the immunity response.  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 1, Ferric Mycobacterium tuberculosis nitrobindin, Mt-Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RES4_ECOLX
Sequence: MRLFGYARVSTSQQSLDIQIKGLKEAGVKASRIFTDKASGSSTDRKGLDLLRMKVEEGDVTLVKKLDRLGRDTADMIQLTKEFDAQGVAVRFIDDGISTDGEMGKMVVTILSAVAQAERRRILERTNEGRQEAKLKGIRFGRKRIIDRNSVLALHQQGTGATDIARRLSIARSTVYKILEDESRVNLSKI
What is the function of this protein?
Site-specific recombination protein.
What are the official names of this protein?
R46 site-specific recombinase.
What is the protein family that this protein belongs to?
Belongs to the site-specific recombinase resolvase family.
Protein: WEE2A_XENLA
Sequence: MRTAMSCGGGLVQRLDFSSSDEEDGLSNGINEGPQKGSPVSSWRTNNCPFPITPQRNERELSPTQELSPSSDYSPDPSVGAECPGTPLHYSTWKKLKLCDTPYTPKSLLYKTLPSPGSRVHCRGQRLLRFVAGTGAELDDPSLVNINPFTPESYRQTHFQPNGKRKERPEDDCRTDRQMKYAEKEHPAVFQSKRFVLRETNMGSRYKTEFLEIEKIGAGEFGSVFKCIKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCNGGSLQDLIVDNNKEGQFVLEQELKEILLQVSMGLKYIHGSGLVHMDIKPSNIFICRKQTELGQEESDGEDDLSSGSVLYKIGDLGHVTSILNPQVEEGDSRFLANEILQEDYSQLPKADIFALGLTIALAAGAAPLPCNEDSWHHIRKGNLPHVPQLLTPIFLALLKLLVHPDPVMRPPAASLAKNSVLRRCVGKAAQLQKQLNVEKFKTAMLERELKAAKLAQTSGKDECSDLPPMSGFSCRGRKRLVGAKNTRSLSFTCGGY
What is the function of this protein?
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis.  Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', which inhibits cdk1 activity and prevents meiotic reentry.  Negative regulator of mitosis.  Involved in the mitotic DNA replication checkpoint.
What are the official names of this protein?
Wee1-like protein kinase 2-A, Maternally supplied wee1-like protein kinase 1A, Xe-wee1A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: RL17_YERPS
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDNVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRAASQAEVVAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: NIFN_RHOCA
Sequence: MAVLTHSRRALSTNPLKTSAPLGAAMAYLGIEGAVPLFHGAQGCTAFGVVHLVRHFKEAVPLQTTAMNEVSTILGGGEQIEEAIDNIRKRANPKFIGIASTALTETRGEDIAGELRAMQVRRKDWVGTAVVHVITPDFEGGQQDGWAKAVEAIVAALVPVTAERDPDLRQVTLLVPSCFTTAEIDEAVRMIRAFGLSPIVLPDLSTSLDGHLSDDWSGHSLGGTRLDDIARIPRSAVTLAIGEQMRAAAPMIEDRALVPYRVFQSLTGLKVVDAFVRVLMELSGMQDPPPSTKRDRARMMDAALDAHFFTGGLRVAIGADPDLMFALSTALVSMGAEIVTAVTTTQNSALIEKMPCAEVILGDLGDVERGAGQAEAQILITHSHGRHAAAALHLPLVRAGFPIFDRIGAQDTCRIGYRGTRAFFFEIANAMQAIHHRPRPEDFGAAPIPQEFDHVPHPAPC
What is the function of this protein?
This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).
What are the official names of this protein?
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifN.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: RL16_SALRD
Sequence: MLEPKDTKHRKVQRNQGLKRNKYAVKGTRLSFGDYGLKSLEEGEVNSRQLEAARVAINRYLKRDGKVWIRVFPDKPKTKTPAETRMGKGKGEPEHFVAPVQPGNVIFEVGGGADEESAREALRLGKHKLPLKTKFVVRPGSRAEE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DCAM_ORYSJ
Sequence: MGVLSAADPPPVSAIGFEGYEKRLEITFSEAPVFADPDGRGLRALSRAQIDSVLDLARCTIVSELSNKDFDSYVLSESSLFIYSDKIVIKTCGTTKLLLTIPRILELAEGLSMPLAAVKYSRGMFIFPSAQPAPHRSFSEEVAVLNRYFGHLKSGGNAYVIGDPAKPGQKWHIYYATQHPEQPMVTLEMCMTGLDKEKASVFFKTSADGHTSCAKEMTKLSGISDIIPEMEICDFDFEPCGYSMNAIHGSAFSTIHVTPEDGFSYASYEVVGFDASTLAYGDLVKRVLRCFGPSEFSVAVTIFGGHGHAGTWAKELNADAYKCNNMVEQELPCGGLLIYQSFDATEDVPVAVGSPKSVLHCFEAENMVNPAPVKEGKLGNLLPWGEDALEENDGVFDE
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: Y2217_SYNC1
Sequence: MTYQRLSLGRWGEDIAAGYLRRQGMKILDRNIRTPVGELDIVARHKRMLIFVEVKTRRGISHGYPQEAVGAAKQRQILRAAQWYLAERRLDRLQPRFDVIAVRRRGDEAEVEHFPGAFDVDGW
What are the official names of this protein?
UPF0102 protein Pcar_2217.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: OTNK_CUPNH
Sequence: MTAGTLAHRPLLGCIADDFTGATDLANTLVRNGMRTVQTIGLPDVGAVQDIGEADALVVALKSRTIPAVEAVAQSLAALQWLRAQGCRQFVFKYCSTFDSTDAGNIGPVAEALLAALDSDFTIACPAFPENGRTIFRGHLFVGDALLNESGMEHHPLTPMTDASLVRVLQRQSKNKVGLLRYDAVARGAHATAERIAALRSDGVRMAIADAVSDADLFTLGEACANLPLITGGSGIALGLPENFRRAGLLPQRGDAASVPAIDGPGVVLAGSASRATNGQVARWLEQGRPALRIDPLALARGEAVADAALAFAAGHGEPVLIYATSSPDEVKAVQAELGVERAGHLVEQCLATVAAGLLARGTRRFVVAGGETSGAVVQALGVRALRIGAQIAPGVPATVTLDAKPLALALKSGNFGGPDFFDEALRQLGGH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of 3-oxo-tetronate to 3-oxo-tetronate 4-phosphate.
What are the official names of this protein?
3-oxo-tetronate kinase, 3-dehydrotetronate 4-kinase.
What is the protein family that this protein belongs to?
Belongs to the four-carbon acid sugar kinase family.
Protein: Y147_UREPA
Sequence: MNYILNKNKKVSLTELMNQQPHWYLEELQEHLIKYLDTNGLNDTKKLIKQTIKEWKK
What are the official names of this protein?
Uncharacterized protein UU147.
Protein: FAU1_HALS3
Sequence: MTRVRVRGIYATALTQLLRNAGLDVVAASPPIRARFPDADLGAAEPHADIRMTPDRQGVGITAHGDDHARAVRAVVADLPRDTFVWPDPVPRGAVFDAAVDHTVGGGAILDLGDDREAYLPFGAVDDHVTDGDTLRVAIRDPAPPWHDDRPTATSTITVSGALASLDRGVDALVAGAATDRAELARATELLDPDIPDNWGVYWEYDGADASLDARGTALDTLAARADRLEATLADADGGDTPGLVAAPDTTLWAWFGRETRCALDDHRRTVAATMPGHHRIKAGSDAASDAVDFAEALGASVDEFPFGAVTDQFGPSVGASIEIQHGKPDGALISLGRGEVTDRSAENARITVEREMTGGGTYDALGVAREAGDTATTRFTEGNWWYPTVYRSEDGERKGTYLNVCTPVEVFPDAVRYVDLHVDVIKHADGAVEIVDREELQDCVADGLVSEELAEKALSVAERVQSAVAE
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Binds to RNA in loop regions with AU-rich sequences.
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: CLPX_TREDE
Sequence: MARNRMGGALICSFCNKPESSERFVVPGPGGIAICDRCVDLCESYIKSYKTVRPVDRSGAIPTPQELKEYLDEYVIGQEQAKRVLSVAVYNHYKRIMNPPLENDVVIEKSNVLLLGPTGSGKTLLAKTLAQKMQVPFAIADATTLTEAGYVGEDVENILLKLIQNANGDIKEAEMGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTSASVPPQGGRKHPNQDMLKIDTTNILFICGGAFVGLDKIVEARISTKPIGFGAEVKKLSEKNLTELYDQVSPDDLVKFGLIPELIGRIPIKVALNELTKEDLTRILVEPKNAIIKQFQATFKLDNVDLHFDKDAITAIAQQAIDQNTGARGLRSIVEKLMLDAMFEAPSIKGRKELIINKKMIGNSSSKPKIKLLDEKTA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL23_TERTT
Sequence: MNQERLYKVLLGPVISEKAAMAAEIANQAVFKVVSDASKSEIKAAVEKLFNVSVEGVRVLNVKGKTKRTRYGMGRRSDWKKAYVTLAEGSEIDFESGE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RR7_LEOCS
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BIOB_SULDN
Sequence: MNQKIFLCSICNINSGTCNEDCKFCSQSVRYKADIDRYKQKEISLILKEAQDAYSNGALGFCLVTSDKGLNDKTLNFVCSIAEVLSKELPELRLIACNGTATIEQLLTLRASGIKAYNHNLETSREFYPKICTTHSWDERYETCQNINNAGLVLISGGIFGLGEREEDRVSMLKSLDSLKPTSVPINFYHHNEALELSPNPLSVDEALSLIKLTRAMIPDAQRIMVAGGRELMFGDRESEIFANGANSIVIGNYLTTSGKAMQRDLEMLKSLNLDVASSVK
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: TAF12_BOVIN
Sequence: MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGTGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.  Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, TAFII20/TAFII15.
What is the protein family that this protein belongs to?
Belongs to the TAF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: A1A1B_DANRE
Sequence: MNDFAVLSTGRKMPLLGLGTWKSEPGLVKQAVIWALESGYRHIDCAPIYANEPEIGEAFQETMGPDKGIRREDVFVTSKLWNTKHHPDDVEPSLLKTLKDLKLEYLDLYLIHWPYAFQRGDTPFPRKEDGTLLYDDIDYKLTWAAMEKLVGKGLVRAIGLSNFNSRQIDDILSVASIKPTVLQVESHPYLAQVELLSHCRDRGLVMTAYSPLGSPDRAWKHPDEPVLLEEPAIAALAKKYNKTPAQIIIRWQTQRGVVTIPKSITQSRIKENIQVFDFTLESEEMSQVTALHRGWRYIVPTITVDGKSVPRDAGHPHYPFNDPY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols.  Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids.  Acts as an aldehyde-detoxification enzyme (By similarity).  Displays no reductase activity towards retinoids (By similarity).
What are the official names of this protein?
Aldo-keto reductase family 1 member A1-B, Alcohol dehydrogenase [NADP(+)] B, Aldehyde reductase-B.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Apical cell membrane.
Protein: RPOZ_COREF
Sequence: MSVTNVSNETNATKAVFDPPMGITAPPIDELLDKVTSKYALVIFAAKRARQINSYYQQADEGVFEFIGPLVTPQPGEKPLSIALREINVGLLDHEEG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: GUAA_HELPG
Sequence: MILVLDFGSQYTQLIARRLRESGIYTEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSGKIFDLNVPILGICYGMQYLVDFFGGVVVGANEQEFGKAVLEIAQNSVIFEGVKIKSLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENGKIFGLQFHPEVVQSEEGGKILENFALLVCGCEKTWGMQHFAQREIARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAVFVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEARLLGKELGVSQDFLMHHPFPGPGLAVRILGEVSESKIKRLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVSNRITNEVSGINRVVYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PLSY_MESFL
Sequence: MFPYLGIIIASIFGYLLGSVLWSVPITKWVKGVSIYEVGSNNPGATNTVRILGKRWGLAVALLDGFKVLITAAFAIGLSMIPNELFSKTSYFIPCIFVLIGHCWPIWFKFKGGKAVSCFLGLLIVVNYLYFLIFFIVWWIFAFKYRKVSLSSIIGTATILLLMWLPWTYGVMGYSLFNGYDSFIVAWDKHIVFSFYNLFHKFSSNIHGSNFADGMLTGQIVILIGMVILVVRHKSNIVKLKNKTEQPIYPKKEKNV
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYRP1_HUMAN
Sequence: MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYLIRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV
What is the function of this protein?
Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458, PubMed:23504663).  Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582).  May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).  Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
What are the official names of this protein?
5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Protein: FOLD_PYRAE
Sequence: MVTWIRGEELHARTKEWARSHVKRLEEVGITPKLAVLLLNDDPVELETQRRFVTLKARDVREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSALSPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILELFKLYGIDVRGKDVVVVGKGELVGKPLAVMLMQLDATVTVLHALSKEREPYVKRADIVISAVGRPPELYKDNPWRLTGDMIKEGAVVVGVGGKVDPATKRWFFDVDEKSVAEKASYLTPNIGGVGLATRARVLKNLIRTTYQVAQRVLSPRLYEV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TNR21_RAT
Sequence: MGTSASSITALASCSRIAGQVGATMVAGSLLLLGFLSTITAQPEQKTLSLTGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPSGTFTRHENGIERCHDCSQPCPRPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKGTENEDVRCKQCARGTFSDVPSSVMKCRAHTDCLGQNLMVVKQGTKETDNVCGVHLSSSSTTPSSPGIATFSHPEHTESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSDIQEETVPDNTSSTSGKESTNRTLPNPPQLTHQQGPHHRHILKLLPSSMEATGEKSSTAIKAPKRGHPRQNPHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIMEKAGLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNVKLENSTLLTVEPSPLDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
What is the function of this protein?
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B.  Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm.  Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning.  Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).  N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).  Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation.  Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells.  Negatively regulates the production of IgG, IgM and IgM in response to antigens.  May inhibit the activation of JNK in response to T-cell stimulation (By similarity).  Negatively regulates oligodendrocyte survival, maturation and myelination.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 21, Death receptor 6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PERQ_SUASA
Sequence: MATLSLPNHSPTFALPSQTPKPHSSQNLSIISKSAHSQFCGIKLSHSSSLSPPLYPRSYKASIVAKVSEGSMPPAFTLKDQDGKNVSLSKFKGKPVVVYFYPADETPGCTKQACAFRDSYEKFKKAGAEVIGISGDDSSSHKAFKQKYKLPYTLLSDEGNKVRKDWGVPSDLFGALPGRQTYVLDRNGVVRLVYNNQFQPEKHIDETLKFLQSL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Peroxiredoxin Q, chloroplastic, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin Q.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: DXR_MANSM
Sequence: MRMPAGFLINAMKKQNLVILGSTGSIGKSTLSVIEHNPEKYHAFALVGGRNVDLMVEQCVKFQPEFAALDDENAAKQLAEKLKSAGKKTKVLAGQKAICELAAHPEADQVMAAIVGAAGLLPTLSAVQASKTVLLANKETLVTCGQIFIDEVKRTKARLLPVDSEHNAIFQSLPPEAQQQIGFCPLKELGINKIVLTGSGGPFRYTDLTEFDNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFNAGAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPGRIVSGVTPLDFYQLSGLTFLEPDYERYPCLKLAIEAFAAGQYATTAMNAANEIAVEAFLNRMIKFTDIARVNAKVVELIQPQQINCIDDVLAVDKQSRLVAKEVIVSLKA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PDLP3_ARATH
Sequence: MGFYSLKQLLLLYIIIMALFSDLKLAKSSSPEYTNLIYKGCARQRLSDPSGLYSQALSAMYGLLVTQSTKTRFYKTTTGTTSQTSVTGLFQCRGDLSNNDCYNCVSRLPVLSGKLCGKTIAARVQLSGCYLLYEISGFAQISGMELLFKTCGKNNVAGTGFEQRRDTAFGVMQNGVVQGHGFYATTYESVYVLGQCEGDIGDSDCSGCIKNALQRAQVECGSSISGQIYLHKCFVGYSFYPNGVPKRSSPYPSSGSSGSSSSSSSSGTTGKTVAIIVGGTAGVGFLVICLLFVKNLMKKKYDDY
What is the function of this protein?
Modulates cell-to-cell trafficking.
What are the official names of this protein?
Plasmodesmata-located protein 3, PD-located protein 3, Cysteine-rich repeat secretory protein 11.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, plasmodesma. Note=Co- localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata.
Protein: RL20_ACIB3
Sequence: MARVKRGVVAHRRHKKILARAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQKKRQFRALWIARINAGARQNGLSYSRMIDGLKKAQVIIDRRVLADIAMHDAVAFAALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: API5_CHICK
Sequence: MPTVEELYRNYGILADATETAGQHKDAYQVILDGVKGGAKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGDNLPRVADILTQLLQSDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPEEVLTKEVEEFILAESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTKFVTYFCEHVLPNLSALTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLESNLKKLFDKLLEYMPLPPEEAENGENAGGEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKADANQKRTSEDTTSSSPPKKASAGPKRDARQIYNPPSGKYSSNLGSFSYEQRGGFRGGRGRGWGGRGNRSRGRIY
What is the function of this protein?
Antiapoptotic factor that may have a role in protein assembly.
What are the official names of this protein?
Apoptosis inhibitor 5, API-5.
What is the protein family that this protein belongs to?
Belongs to the API5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear.