PharMolix/UniProtQA huggingface dataset:
Protein: SECA_BUCAP
Sequence: MFIKFLHKIFSNRNDRILKKFKKIVSSINQLEEKFKKLSDKKLQENTGIFRLRLKKGECLDDLLPESFATVREASRRVFNMRHFDVQILGGIVLNKQCIAEMRTGEGKTLTSTLPAYLNALTGRGVHIVTMNDYLAERDAKNNTPLFEFLGLTVGLNLPEMSFIDKKKAYLCDITYGTNNEYGFDYLRDNMIFSAEERVQRELNYALIDEVDSILIDEARTPLIISGPSEDSSFLYKEINKLVPSLICQKKEDSDKFHGNGHFSIDEKSKQIYLTERGLVEVEKILLDRKLMKKEESLYSSNNIILMHHVISALRAHNLFTRNIDYLVKDNNIIIVDEHTGRTMPGRRWSDGLHQAIEAKENVTVRNENQTLASITFQNYFRLYKKIAGMTGTAATESFEFSSIYNLDTVIIPPNKPMIRKDLSDLVYMTEEEKINAILKDIKNCIKKNQPVLVGTISIEKSEMISKKLKILNIKHNVLNAKFHAREAEIIAQAGKPKSVTIATNMAGRGTDIVLGGSLESQLEKNMYLDKIETIKRNWKKQHDLVVLSGGLHIIGTERHESRRIDNQLRGRSGRQGDSGSSRFYLSMEDSLMRIFASDKIISMMRKLGLSLNEAIEHPWVTKAIENAQKKVENRNFDIRKQLLEYDDVCNEQRRVIYAQRNKLIDSENIQQNIYDILKDVLHSIIKTHLNFDFPKNTRNILDLENKLSIEFNLNISIKDWLKKDHDIKKENIIKKIIDIAKKNYLNKEIQIGFHNIRMIEKSIMLKTLDSLWKEHLSAMDYLRQGIHLRGYAQKDPKQEYKRESFNMFSNMLELLKYEVISFLSKLDISYIKSNLHLNMNNNSSIVNNDIKMGRNTPCFCKSGKKYKYCHGSL
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: Y016_RICPR
Sequence: MNKLTAQNLLKKSRFLKYSLLTSISVGAVMAIPVERIAMGMDQEAFCAELSKKLSLEFSQSYEDTISTTQEKNNLSNNGPSNKSDMAEELANVTTKSLYKVRKMQAPEFKISENKFLNNLDSQTISKELDPNTYTTESISQKPEIILTASSTTVSTDSNSFVTVSTASSLKPVTSYQPTPDFKPNYSLGFNTPINTNLKIVRKLSFSSEQPQIVQHSKSMIPLMPTAPVVLPKSSIEIEPEMVSNIPRVDDTISIKSSEVREDIKGTKDQKTLVDQFNSSIGIWSKKTGKNKYDLNKDSSQK
What are the official names of this protein?
Uncharacterized protein RP016.
Protein: GLMU_STRPQ
Sequence: MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMRQRITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHAFIGSNSTLIAPLEIGDNALTAAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBG_CAEEL
Sequence: MSGTGALMTVHVGQCGNQLAQAFWKSMVDEHGINERGQTTHEDDMNDKKDLLFYQADDDHYVPRAVLVDLEPRVINGMMQSPNFSNLFNTDNIFMSDHGGGAGNNWASGYCQGQEVQEKIMDIIIREAENTNNLDGILFTHSVSGGTGSGTGSLLLERLREAFPKKVIQTYSVFANSDTSTDVVVHPYNWVLSMQRLIENPDHVVVLDNAALHRLAAGKFKTDTPTFDHINSLVARIMSTSTAPYRFNSAMCPSIRYLDLAPFPPMHFIQSAISPVVDPNENFTRKTSVADVTRFLLKPTSMMVSTASRVRPNDCMLSAYMFLQGQIEAHTIMTAEQNVDFAIRRPPFYMLKPLRMMHAPLSPYVRPQYKVSGLLLNNSTSVAPLFESLLSKYDKLRSKRAFIDKFEKIDNFSLDMMDDAMHIVQDLLDEYKAVVQKDYLTRGL
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, hemidesmosome. Cell junction, adherens junction.
Protein: ERFB_SCHPO
Sequence: MSYEKHSDAKASRYAWNQPWNPFEVTLSDPTYPMNLEEKNQIPYRFQSVPDDVPEVPHIESRYKNLPGNNIYLCCGRLQMSSQYKAFLISLFALILPGVLFFIFSAFWLWHHVSPAVPITFAYLYALAVVSMFKCSTADPGILPRNAYSLTYNPAHPWSVIPEDRKVLVGSTRSDSVFVNTVYCHTCHLYRPPRASHCHLCDNCVEYLDHHCIWLNTCIGRRNYRYYFIFLLSVVLSALYLTGLGFYTSIGSFHESTDTNFAAHLRRPWAGVSFFLGIYGALGAILPGILFCYQCYLISVGQNVHEYLRAKSTETEDVHPFHDSIWLNFLVVLCRPKNVSYVRPTRKSYV
What is the function of this protein?
The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development (PubMed:23843742, PubMed:16303567).  Palmitoylates ras1 (PubMed:23843742).  Palmitoylates isp3 (PubMed:23843742).  Palmitoylates rho3 (PubMed:23843742).
What are the official names of this protein?
Palmitoyltransferase erf2, DHHC cysteine-rich domain-containing protein erf2, Meiotically up-regulated gene 142 protein, Ras protein acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
Protein: Y1387_VIBC1
Sequence: MLCSIYKSSRKEGTYLYIPKKDDFSQVPDTLMQMFGKPMPVMTIKLDGRTLAQVDVEKVKASLINDGFFLQVPPPPENLLEKYKEQKAQQKGE
What are the official names of this protein?
YcgL domain-containing protein VIBHAR_01387.
Protein: NUOK_NEIMB
Sequence: MITLTHYLVLGALLFGISAMGIFMNRKNVLVLLMSIELMLLAVNFNFIAFSQHLGDTAGQIFVFFVLTVAAAESAIGLAIMVLVYRNRQTINVADLDELKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UREG_ORYSI
Sequence: MASHDHDHHHHHHHSHDDGDHHHSHHQDGSHGGGGGSWVGEDGRVWHSHDGLAPHSHEPIYSPGDFSKRAPPLISRRFAERAFTVGIGGPVGTGKTALMLALCRSLREKYSLAAVTNDIFTKEDGEFLIKHGALPEERIRAVETGGCPHAAIREDISINLGPLEELSNLYKADLLLCESGGDNLAANFSRELADYIIYIIDVSGGDKIPRKGGPGITQADLLIINKTDLAPAVGADLAVMERDALRMREGGPFVFAQVKHGVGVEEIVNHILQAWEIATGNKRR
What is the function of this protein?
Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein G, AtUREG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
Protein: BTUC_ESCF3
Sequence: MLTFARQQQRKNIRWLFCLSALMLLTLVLSLCAGEQWILPADWFSPQGELFVWQIRLPRTLAVLLVGAALALSGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVFLGQGQLPGWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSAMMTWAIYFSTSFDLRQLMYWMMGGFGGVNWQQAWLMVALIPVLLWICCQSQAMNMLALGETSARQLGLPLWFWRNVLVVATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRMLLPGCALAGAIALLLADVVARVALVAAELPIGVVTATLGAPVFIWLLLKSRA
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPIKE_CVBLS
Sequence: MFLILLISLPTAFAVIGDLKCTTVSINDVDTGVPSISTDTVDVTNGLGTYYVLDRVYLNTTLLLNGYYPTSGSTYRNMALKGTLLLSTLWFKPPFLSDFTNGIFAKVKNTKVIKDGVKYSEFPAITIGSTFVNTSYSVVVQPHTTNLDNKLQGLLEISVCQYTMCEYPNTICNPNLGNQRVELWHWDTGVVSCLYKRNFTYDVNADYLYFHFYQEGGTFYAYFTDTGVVTKFLFNVYLGTVLSHYYVMPLTCNSALTLEYWVTPLTSKQYLLAFNQDGVIFNAVDCKSDFMSEIKCKTLSIAPSTGVYELNGYTVQPIADVYRRIPNLPDCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNRRFGFTEQSVFKPQPAGVFTDHDVVYAQHCFKAPTNFCPCKLDGSLCVGSGSGIDAGYKNTGIGTCPAGTNYLTCHNAAQCGCLCTPDPITSKATGPYKCPQTKYLVGIGEHCSGLAIKSDYCGGNPCSCQPQAFLGWSVDSCLQGDRCNIFANFILHDVNSGTTCSTDLQKSNTDIILGVCVNYDLYGITGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYLTNRTFMIRSCYSGRVSAAFHANSSEPALLFRNFKCNYVFNNTLSRQLQPINYFDSYLGCVVNADNSTSSVVQTCDLTVGSGYCVDYSTKRRSRRSITTGYRFTNFEPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMEEFIQTSSPKVTIDCSAFVCGDYAACKSQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSDCNKVSSRSAIEDLLFSKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYNGIKVLPPLLSENQISGYTLAATSASLFPPWSAAAGVPFYLNVQYRINGIGVTMDVLSQNQKLIANAFNNALGAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISSSLQEILSRLDALEAQAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPTKYVTAKVSPGLCIAGDRGIAPKSGYFVNVNNTWMFTGSGYYYPEPITGNNVVVMSTCAVNYTKAPDVMLNISTPNLPDFKEELDQWFKNQTSVAPDLSLDYINVTFLDLQDEMNRLQEAIKVLNQSYINLKDIGTYEYYVKWPWYVWLLIGFAGVAMLVLLFFICCCTGCGTSCFKKCGGCCDDYTGHQELVIKTSHDD
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: ULAD_SALG2
Sequence: MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIQQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAESPVEAARQFKRSIAQLWG
What is the function of this protein?
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
3-keto-L-gulonate-6-phosphate decarboxylase UlaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase, KGPDC, L-ascorbate utilization protein D.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. KGPDC subfamily.
Protein: SELA_YERE8
Sequence: MSAEPHHLYSQLPAIDSLLRAPEMAPLLDEYGAALLTENLRLMQAEAREYIRQFHTLADWCADWPAALRHRLNQRQPALKPVFNLSGTVLHTNLGRAPLAESAIAAVTDAMRGAVTLEYSLSGAGRGHRDRAVADLLCELTGAEDACIVNNNAAAVFLMLTVMAAGKQVVVSRGELVEIGGAFRIPDVMRQAGCELVEVGTTNRTHLKDYRQAISEHTGLLMKVHTSNYSIEGFTASVAEQQLAALGHEFAIPTATDLGSGSLVDMTRYGLPAEPMPQQLIAAGVDLVTFSGDKLLGGPQAGIILGKKQWIDQLQQHPLKRVLRADKMTLAALDATLRLYQQPDRLTELLPTMRLLTRPAQDIAESAQRVLAALNGSYAADFTLAVESCWSQIGSGSLPVDRLPSWAVTFTPKDGSGSALEALTVRWRGLAKPIIGRVADGRLWLDLRCLEDEAALLRELAP
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVO2_YEAST
Sequence: MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED
What is the function of this protein?
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity.  TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
What are the official names of this protein?
Target of rapamycin complex 2 subunit AVO2, TORC2 subunit AVO2, Adheres voraciously to TOR2 protein 2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HRCA_CHLAB
Sequence: MSKSWISKRESKLLYILLTTTELYLKTGQPVGSKTLKEYECSNLSTATIRNYFAELEAEGFLKKNHVSGGRIPTDLAFRYYVDHRADFLQDDLPETTIHLLNQLPKESQNIVKDLQKASELLGEALQLPTCFSSPRFENDSVTNIQLSLVDEQRVVVILSTEFGQIFTDTLWLAETSNYASLKRIETFLQNYLRKQPPSETLSQKEEDLGMTLYNEVVVRYLTRYCNFSEEDLYQTGLSKLLKYDAFKDPDMLALGLSFFESRCHMCKLLDIGMHRDRPTAFIGSELSDIFGTPNPHCAVITTPYYMNRTPLGAFGVLGPINLPYREIYKTLTIFADKVKESLTQSFYKFKLSFRRPCPSDPKLSKEPTLLARYSSIKLLPPKETS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: YQJV_BACSU
Sequence: MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASASYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFFVVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSSQSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIALVGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKRFSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKPGLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAYRQMKMETTKHRSRLEKPL
What are the official names of this protein?
Uncharacterized MFS-type transporter YqjV.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TXK_HUMAN
Sequence: MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
What is the function of this protein?
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response.  Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.  When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420.  Phosphorylation leads to TXK full activation.  Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton.  Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates.  In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty.  Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976).  Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976).  Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2.  Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
What are the official names of this protein?
Tyrosine-protein kinase TXK, Protein-tyrosine kinase 4, Resting lymphocyte kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
Protein: RECO_BACAC
Sequence: MFQKVEGIVIRTTDYGETNKIVTIFSRELGKVSAMARGAKKPKSRLASVSQLMTHGHFLIQMGSGLGTLQQGEIISTMKEIREDIFLTAYASFIVELTDKATEDKKHNPYLFEMLYQTLHYMCEGVDPEVLSLIYQTKMLPVLGMRPYFDTCAICHQETDFVAFSVREGGFLCSRHAEQDQYRIPVGEAVHKLLRLFYHFDLHRLGNVSVKDSTKKQMRLVLNTYYDEYCGIYLKSRRFLEQLDKFQI
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SERA_METTH
Sequence: MSRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMPVMDSETYKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAEMQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVTEARRSESDGYRSIIIATAESDRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIATMQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI
What are the official names of this protein?
D-3-phosphoglycerate dehydrogenase, PGDH.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: METK3_CATRO
Sequence: METFLFTSESVNEGHPDKLCDQVSDAILDACLEQDPESKVACETCTKTNMVMVFGEITTKATVNYEKIVRDTCRGIGFTSPDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNKTCPWLRPDGKTQVTVEYRNEGGAMVPIRVHTVLISTQHDETVTNEQIAQDLKEHVIKPVIPAQYLDDQTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVASGLARRCLVQVSYAIGVAEPLSVFVDTFKTGKIPDKDILALIKENFDFRPGMIAINLDLKRGGNFRYQKTAALGHLGRDDPDFTWETVKILKPKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 3, AdoMet synthase 3, Methionine adenosyltransferase 3, MAT 3.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_BLUHO
Sequence: MVSADATPKGQMTVLDALKGALRTALMHDGLARGLREASKALDRREAHMCVLNEACEEEAYKKLIVALCSEHKIPLIKVPDGKQLGEWAGLCVLDREGNARKVVNCSCVVVKNWGEESSERMMLLNYFQTEQ
What are the official names of this protein?
40S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS12 family.
Protein: PVK2_LOCMI
Sequence: GLLAFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, Lom-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ERG3_NEUCR
Sequence: MDVVLEVTDQFMFDYMYAWLLPARPALYDFPDKTNGTAQAFSSWVYEPATKFFSLEPSQAAYQSIWTRDNIYRQALSLFLILWLFGLVTYYVFASLSYIFVFDKKTMEHPKFLKNQVWLEIKQTNAALPVMAFFTFPFLVAEVRGYSLLYDTTAEGPGRWYDFFQFPLFIMFTDFGIYWIHRGLHHPLVYKHLHKPHHKWIMPTPYASHAFHPIDGFAQSIPYHIFPFIFPLQKMAYVGLFVFINFWTIMIHDGEYYANNPVINGAACHSVHHFAFNYNYGQFTTLWDRLGGSYREPDGDMFAKEKKMSTTTWKKQVNEMEKIVKEVEGEDDRLYEPTETKKSK
What is the function of this protein?
Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol.  May contribute to the regulation of ergosterol biosynthesis.
What are the official names of this protein?
Probable Delta(7)-sterol 5(6)-desaturase, C-5 sterol desaturase, Ergosterol Delta(5,6) desaturase, Sterol-C5-desaturase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS4Y2_PANTR
Sequence: MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIVFLRNRLKYALTGDEVKKICMQRFIKIDGKVRVDITYPAGFMDVISIEKTGEHFRLVYDTKGRFAVHRITVEEAKYKLCKVRKITVGTKGIPHLVTHDARTIRYPDPLIKVNDTVQIDLGTGKITSFIKFDTGNVCMVIGGANLGRVGVVTNRERHPGSCDVVHVKDANGNSFATRISNIFVIGNGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG
What are the official names of this protein?
40S ribosomal protein S4, Y isoform 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: MUTS_PARPJ
Sequence: MGIQTAAANDVAQHTPMMQQYLRIKADHPGTLVFYRMGDFYELFFEDAEKAARLLDLTLTQRGASAGNPIKMAGVPHHAVEQYLAKLVKLGESVAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKSDVYLLAMCVAHNRRGVATSVGLAWLNLASGALRLAEVAPDQVAAALERIRPAEILVADTPSDSASWTPPVNAGALTRVPVWHFDVTSGTQRLCDQLEVAGLDGFGAHSLTCACGAAGALLLYAAATQGQQLRHVRSLKVEYESEYIGLDPATRRNLELTETLRGTESPTLCSLLDTCCTTMGSRLLRHWLHHPPRESAVAQARQQAIGALLDAPPGASIDSLRGALRQISDIERITGRLALLSARPRDLSSLRDTFIALPELRTQVAAVAPNADSLARIDASLEPPQACVELLKRAVAQEPSAMVRDGGVIARGYDAELDELRDISENCGQFLIDLETRERARTGIGNLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALARERSLYDALLQALLPFIPDCQRVASALAELDLLAAFGERARALDWVAPTFSANAGIEIEQGRHPVVEAQVEQFIANDCSLTPERKLLLITGPNMGGKSTFMRQTALIALLAYVGSYVPARRAAFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPQSLVLMDEIGRGTSTFDGLALAWAIARHLLAHNGCHTLFATHYFELTQLPAEFPQAANVHLSAVEHGHGIVFLHAVSEGPANQSYGLQVAQLAGVPNAVIRAARKHLAHLEQQSAAQPAPQLDLFATPMPMLLEDADDERDAKAEPAVPPAMQELVERLRGIDPNDLRPREALDLLYELHELAAAPDADH
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: FLPA_PYRCJ
Sequence: MSIEVVEVRPHELHYGVYVVRFEDGTERLATRNLTPGRRVYGERLIKWEGVEYREWNPYRSKLAAAILNGLKLVPIREGTHMLYLGAASGTTPSHISDIVGERGLIYSVEFSPRVFREFMEKLVDQGRRNVIPILGDARFPYQYAHYIKGVDVVYIDVAQPAQAKILADNADYFLKPGGYVMLVIKAMSIDVTAPATETFKQEINTLKERGFDVLETVHLEPYDTAHAMVIARK
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.