PharMolix/UniProtQA huggingface dataset:
Protein: FCERG_PIG
Sequence: MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKLQVRKAAIDSYEKSDGVYTGLSTRNQETYETLKHEKPPQ
What is the function of this protein?
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors.  As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells.  As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production b basophils priming T-cells toward effector T-helper 2 subset.  Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells.  Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes.  May function cooperatively with other activating receptors.  Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation.  Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
What are the official names of this protein?
High affinity immunoglobulin epsilon receptor subunit gamma, Fc receptor gamma-chain, FcRgamma, Fc-epsilon RI-gamma, IgE Fc receptor subunit gamma, FceRI gamma.
What is the protein family that this protein belongs to?
Belongs to the CD3Z/FCER1G family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ISPG_YERPB
Sequence: MHNGSPIIRRKSTRIYVGKVPIGDGAPIAVQSMTNTKTTDVDATVAQIKALERVGVDIVRVSIPTMDAAEAFKLIKQQSTVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNESRIREVVACARDYNIPIRIGINGGSLEKDIQEKYGEPTPEALLESAMRHVDILDRLNFDQFKVSVKASDVFLAVNSYRLLAKQINNPLHLGITEAGGARSGSVKSAIGLGLLLSEGIGDTLRISLAADPVEEVKVGFDILKSLRIRARGINFIACPTCSRQEFDVIGTVNALEQRLEDLITPMDVSIIGCVVNGPGEALVSTIGVTGARNHSGFYEDGVRQKERFDNKAMIDQLEAKIRAKASILDANNRIVINQLDDNK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: AHBM_STRCM
Sequence: MVDRDIRIAVVGAGVAGLTVAALLRDRGVDCRVFERAPRLVAVGAGIQLSPNGVRVLHGLGLRDSLAATGVRARAIETRSWADGAPIARTPLGDRCEELYGAPYYLIHRADLHRCLTSLLPASAVELGRACARVEERPDAVRLHFTDGTMADADLVIGADGVHSVVRRSVVRDAPRYAGYAVHRGLVPASVVPSFRDDPRVMFWLGPGRHVTYYPVAGGRTVHFSAVGVSPEESPGGGPEDLGAAFGHWHEEVRRVVTSASSVTRWGLYDRDIPDRYATGRVVLLGDAAHPTLPYLSQGANQALEDVTTLVGCLDARPGAPQEAVRQYESLRLPRTAEVHRRARRLAEEFHLPDGPECTDRDQRMRATQDPTHLAWLYGRTAGLPDASDLAPRP
What is the function of this protein?
Part of a gene cluster involved in the biosynthesis of cremeomycin, a light-sensitive o-diazoquinone with antibacterial and antiproliferative effects (PubMed:26278892, PubMed:26689788).  Catalyzes the hydroxylation of 3-amino-4-hydroxybenzoate (3,4-AHBA) to 3-amino-2,4-dihydroxybenzoate (3,2,4-ADHBA) (PubMed:26278892).
What are the official names of this protein?
3-amino-4-hydroxybenzoate 2-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the 6-hydroxynicotinate 3-monooxygenase family.
Protein: PURA_NATTJ
Sequence: MSSVIVVGSQWGDEGKGKVTDYLAEDSGVIVRYQGGNNAGHTVSIGDKVYKLHLIPSGIFHGNKTCVLGNGMVIDPKSLIEELEYLKNHGITSFELIISDRAHVIMPYHKVIDEMEEQEKGDKKIGTTGKGIGPCYMDKASRVGVRMGDLVDEEELEDKVRWAVEKKNELLKDVYGADGFDSESVIQEYKKYAEKLKPFIKDASVFLEQAYNRGEEILFEGAQGTLLDLDHGTYPYVTASNPVTGGACVGAGAPPHLINSVVGVVKAYSTRVGDGPFPSELTGEIGDQIREKGKEYGTTTGRPRRVGWLDTVILNYSRRINGFNHIALTLLDVLSEFDTIKICVAYKYRGETIEHFPASQKILSECEPVFEELPGWKEDISQIQDWDELPDAAKSYIKRIEDLTSVPVSIVSYGPRRSQTKIRNKIKNK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_ECODH
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SYFB_STRP3
Sequence: MLVSYKWLKELVDIDVTPAALAEKMSTTGIEVEGIEVPAEGLSKLVVGHVLSCEDVPETHLHLCQVDTGDETPRQIVCGAPNVKAGIKVIVAVPGARIADNYKIKKGKIRGMESLGMICSLQELGLSDSIIPKEFSDGIQILPDEAVPGDAIFKYLDLDDHIIELSITPNRADALSMRGVAHEVAAIYGKSVSFPEKNLQESDKATSEAIEVAIASDNVLTYASRVVENVKVKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDYDKFEDHKIVTRAARQGESLVTLDGEKRELTTEDLVITVADKPVALAGVMGGQATEIDANSQTVVLEAAVFDGKSIRKTSGRLNLRSESSSRFEKGVNYATVLEALDFAAAMLQELAEGQVLSGHVQAGQLSTEPVEVSTNLDYVNVRLGTELTFADIQRIFNQLGFGLTGDETRFTVAVPRRRWDISIPADLVEEIARIYGYDKLPTTLPEAGGTAAELTPTQALRRKVRGLAEGLGLTEIISYALTTPEKAIEFAVAPSHLTELMWPMSVERSALRQNMVSGMLDTVAYNVARKQSNLALYEIGKIFEQEVNPKEDLPNEVNHFAFTICGLVAQKDFQTQAQAVDFYHAKGILDTLFANLNLKVQYVPTKDLANMHPGRTALILLDEQVIGFVGQVHPGTAKAYSIPETYVAELDMAALEAALPSDQTFAEITKFPAMTRDIALLLDREVSHQAIVTAIESAGVKRLTKIKLFDVYEGATIQAGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITKALTEQVGAEVR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PVK1_SUPLO
Sequence: GSSGLIAMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, SupLo-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MAO1_YERPN
Sequence: MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERAYRQYQDFKNDDDKHIYLRNIQDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPNVLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMMSEGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSDDLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEELIREMHSHCARPIVMPLSNPTSRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGASRVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTSEEALSKAIEHNYWQPQYRSYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: BDLA_PSEAE
Sequence: MAALDRSMARVEFDPDGNITDANENFLTLLGYRRDEILGKPHRQLCDGAYAQSEDYRRFWERLRRGEHFSGRCKRITREGRPLWLEATYNPVRDGQGRLLKVVKYASDIDAIVHQEHEMQSKLDALSRSMAMIEFDLDGNVLAANDNFLATMGYGRAELASANHRQFCEPGYRDGPQYADLWRRLNRGEYVTGQFRRVHRNGQPVWLEASYNPVYDADGKLYKVVKFASDVSDRMRRYQAEADNAHQAHTLSTETRTVAEHGALIIQSAVEEMLKIANTLDASSLNIGELSQHSQQITSIVNTIREIAEQTNLLALNAAIEAARAGDQGRGFAVVADEVRQLAERTSKSTKEIADMIGRIQTGTRSVIDDMQHSQEQARRGVELANEAGAAILGIRESTHKVVEAVQQFSRTLNADL
What is the function of this protein?
Essential for biofilm dispersion by sensing environmental cues.  May be involved in sensing and transducing signals within cells, resulting in the modulation of c-di-GMP levels, swimming motility and adhesiveness of the bacterial cell surface.
What are the official names of this protein?
Biofilm dispersion protein BdlA, Chemotaxis regulator BdlA.
Protein: CDC64_HALSA
Sequence: MTPDSSPSSVDDPLFESGHRIFANKDLLKIGHVPEADRIVGRDEEISKLAKRLNGAVHGYSPENVMIYGKTGTGKSLVSKHVCQRAQNAAQDGVEIGTAYIDCAEDNTETQAISSLAAKLNDESSTGISVPHTGLSTSKYYKLLWKTLDAQFDSVIIILDEIDLMNDDSVLMKLSRAEEAGKIDCSVGVIAISNKIQYVDNVNERVKSSFQHKELFFKPYDANQLREIMFNREDAFQDGVLSEDVIPLSAAFAAQEHGDARKAIDILRHAGEVAYEAGAELVTEEHVRQAQQHAEKDRFRELVNGAPTQAKAALLALTELSVNSNDDAFLTSRVYDQYEHICNHLDMDILSVRRFRDILKEQAFLGVVEIEKINKGSAGGIHLQNRLIEDSQVVRETILEDSRMQDWTRE
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 4.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: MCSB_BACVZ
Sequence: MSLKHFIQDALSNWMKQKGPESDIVLSSRIRLARNFENIKFPARYTNEEASSIIQQFEDHFSGKELPDIGQFHLIRMSEAQPLEKRVLMEKHLISPNLTESPFGGCLLSENEEVSIMLNEEDHIRIQCLFPGFQLLNAIKAANQVDDWIEEKVDYAFGEKRGYLTSCPTNVGTGLRASVMMHLPGLVLTRQMNRIIPAINQLGLVVRGIYGEGSEALGNIFQISNQITLGKSEQDIVDDLNSVAAQLIEQERSAREALYQTSKIELEDRVFRSYGVLSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRPNERDARRAALIRERLHLEMSANRQEDDSI
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in a large number of proteins.  Is part of the bacterial stress response system.  Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: NDHI_DIMVE
Sequence: MFPMVTEFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y4256_DESHD
Sequence: MKLAIIGGYNFERHSKSMGKLKNIELRFHDGVPKKNNKKVLENLIKDTDCVIIVQMVCSHSSMWDAKDVARKYNKKIYYSQAKGLASVLTMIEKEHGIRTA
What are the official names of this protein?
UPF0751 protein Dhaf_4256.
What is the protein family that this protein belongs to?
Belongs to the UPF0751 family.
Protein: RL24_RHOPT
Sequence: MAAKIRKGDKVIVLSGRDKGRTGEVFEVRPDAGKALVRGINVVKRHQKQTQTQEGGIISKEAPIDLSNIAIVGKDGKPTRVGFKILADGKKVRVAKRSGAEIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LPLT_ECO57
Sequence: MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHEQLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LPP1_SALT4
Sequence: MNRTKLVLGAVILGSTLLAGCSSNAKIDQLSSDVQTLNAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNQATKYRK
What is the function of this protein?
A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes.  The only protein known to be covalently linked to the peptidoglycan network (PGN).  Also non-covalently binds the PGN.  The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
What are the official names of this protein?
Major outer membrane lipoprotein Lpp 1, Braun lipoprotein 1, BLP 1, Murein lipoprotein 1.
What is the protein family that this protein belongs to?
Belongs to the Lpp family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its lipidated N- terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus.
Protein: PYRG_PSYIN
Sequence: MTTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEVFVTDDGAETDLDLGHYERYIRTRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHITNEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQLGLKVGRDSVIYMHLTLLPYLKTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRDVDSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTELPDAYKSVNEALKHGGLKNAASVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEGKILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAHSTEFEANCDQPVVGLITEWLDKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPILEKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQQGRFE
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: KTHY_STRPI
Sequence: MSKGFLVSLEGPEGAGKTSVLEALLPILEVKGVKVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLEKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RS16_CANGA
Sequence: MSTVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFANIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKFVDEQSKNELKKAFTSYDRTLLIADARRPEPKKFGGKGARARFQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CCR4_NEOFI
Sequence: MADGTYRFQQPGAGQFFFQTQPQQHSHQRHIARNGTNSPTGRLKFNHDTPSPSRSPPLSQAAALNPFNMYSQTHQGQHVMMNGGQAHQRFGMQIPKFQSQSHHPHHTQQPHHHTHHNQASHNINHQHNFSSGALASATPHFTPSHIQNGAHTNVDEDIDESMNEHWQQQLQLAAESRQASSPHYHARSVAQQAKGIQIAPSQPETQEQVPDGQNGVVKAKASSRQGWHALDFGGQGLRALSTSLFNYVFLEKLYLNHNKLKALPPTIGQLRKLNHLDLSGNDLTELPEEIGMLTNLKKLYLFDNNIRTLPYEMGYLYRLETLGVEGNPLNDVLKSHIMKEGTKALIKYLKEEMPVHLPPPDRDWIVLDETASSSNHRTDKVTVLSYNTLCDSSATQSHYGYAPARVLSWEFRRELILNELRSHDSDIICLQEIDQGSYNEYFREQLAYNDYKGVYWPRGRAMGMQEEDAKCVDGCATFFKASKFILLDKQLINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVVFLENRQTGSRFIVVNAHLYWDPAFKDVKLIQTAILMEELTKLSETYAKWPPCTDKAAFRFSKEEGQSETPPLEEPAPSMQYASGDQIPLLMCGDLNSSPGSAAYNLIAHGRLDEEHPDLEKRLYGNLSKVGMTHPFKLKSAYGAIGELPFTNYTPDFKDILDYIWYSSNSLHVSALLGEVDKDYLQRVPGFPNYHFPSDHIALLAEFTVKGKKGKVVEADFGPQRN
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LTK_DANRE
Sequence: MDYITRQTFVKLALFIFTVLRSSCALLEKAAEDPVHPNPLQSSPAEDSDVSFCDFESPCSWTLSSHSTGGDWFITSAQQHRSSRRDTQPIRDYSTGKSEGHFLLLKPSSSHLSAGRCSFHMTSPVVLSSGPFCHLQLARFQPEPHAGNISAFVKHTDSTDIKPIDLTIKEQESDSSQWEVLEAVIGQLNEPFQVTVQYSACSSHEVGFLAFDSLELKNCVMGDDYVDLGSDCEKYSSLQCHSGGCIEKQRVCDFHTDCPEGEDEGLICSTLPLGSYCSFELGSCGWLAADTQSSWRLVSGQQLIEDTHLLGTTLKNTQGHFLFLKVRGHGDEREALVQSPALPSTISNQDCQLQFSLYRYGDFNGTVLLSVVESGASAPALIWERSGHWKDAWQEITLPITEILNGFHLKVQAFWTSGSKADIALDDISLSAACFDTELNELLHEGLPHDLDFSPLPEPSASEASPITWWFTSCGASGPFGPTQAQCDSAYRNTNVSVVVGKEGPLRGVQMWKVPATNTYKISAYGAAGGKGAKNHNKRSHGVFISATFPLEKGDILYILIGHQGEDACPGRNPQTHKICLGESSVIEDGFDSDGSALKWAGGGGGGGGATYIYRMENGQPLPLLIAAGGGGKAYLEDPESSQDQSFREQYENDTTVSGVSGRSGAAGGGGGWSDVSSLSWAGKSLVEGGQGGSSCPEALSVLGWATFGGFGGGGGACSAGGGGGGYRGGDAPLLDDISADGQDGLSFVHPMGKIFLQPLAAMESHGEAEIVVYLNCSHCKTQSCKRDEDTKLILCLCDSDEVLAPDNVTCAGTKHSLCQFINKHLQHNSSPLVCPPLVVPMGSLADGPPSLVFIMAVIVSTVVTGVVLTCASLTLIYYRKKNHLHAVRIRLQSPEYKLSKIRSSTIMTDYNPNYGYFGKAASLSELKEVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMDFLMEALIMSKFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRPRTNHSSSLSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTILERINYCTQDPDVINTPLPVECGPPVEEEGGTVIRPDGSGSMTPLLVARSLSQDASPRASITSVTPQALKPRLQLQRPVHLTQEVGTYRETLEPCWAEPVPASGVCPGPWLQVPEHRPCSRSSSSSGSQKLKNKTKNLWNPTYGSWVLESFGRGKSALCHTQSMPLSCNPTSVSAPSSTSEHTDPVVEVNANVSASPPPSAAPSQTTLTPTAAPSRKSPTGAAGVSLATVMDLAKLQSFPCGNVNYAYDEQSYETESLPVVVSKSLEPSTSSAATSSLVALSQPGSFTHKPLVKRHASYGHEDVRRYTQPEKPTRDRDSGFSLSEDLSVTPV
What is the function of this protein?
Receptor tyrosine kinase required for the establishment and proliferation of iridophores and their progenitors from multipotent neural crest cells (PubMed:18369445, PubMed:23821036, PubMed:26801003, PubMed:29078341, PubMed:29317532).  Iridophores are the blue-tinted cells that reflect light to give fish their metallic shine and which, together with yellow xanthophore and black melanophores, generate the zebrafish's stripes (PubMed:18369445, PubMed:23821036, PubMed:26801003).  Following activation by alkal ligands (alkal1, alkal2a or alkal2b) at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:29078341, PubMed:29317532).  Ligand-binding to the extracellular domain induces tyrosine kinase activation, resulting in the activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity).  Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase receptor, Anaplastic lymphoma kinase 1, alk-1, Protein moonstone, mne, Protein shady, shd.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RHMA_SALA4
Sequence: MNALLSNPFKEGLRKGDTQIGLWLSSTTSYMAEIAATSGYDWLLIDGEHAPNTVQDLYHQLQAIAPYASQPVIRPIEGSKALIKQVLDIGAQTLLIPMVDTAEQARQVVSATRYPPLGQRGVGASVARAARWGRIDNYMAQANESLCLLVQVESKVALENLDAILEVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIEACIYRIRAAGKAAGFLAVDPAMAQKCLAWGANFVAVGVDTMLYTEALDSRLAMFKSVQSVSTAKRSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: NUSB_ECO27
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: FRLD_SHIFL
Sequence: MKTLATIGDNCVDIYPQLNKAFSGGNAVNVAVYCTRYGIQPGCITWVGDDDYGTKLKQDLARMGVDISHVHTKHGVTAQTQVELHDNDRVFGDYTEGVMADFALSEEDYAWLAQYDIVHAAIWGHAEDAFPQLHAAGKLTAFDFSDKWDSPLWQTLVPHLDFAFASAPQEDEALRLKMKAIVARGAGTVIVTLGENGSIAWDGAQFWRQAPEPVTVIDTMGAGDSFIAGFLCGWSAGMTLPQAMAQGTACAAKTIQYHGAW
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate.  May function in a fructoselysine degradation pathway that allows S. flexneri to grow on fructoselysine or psicoselysine.
What are the official names of this protein?
Fructoselysine 6-kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: MURC_PROMM
Sequence: MSLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQGVRVFRDQSAANIDAICSNVDLLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPYYDSNGHVGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFDATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLEGLSFEDVQQGLADLQPPGRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTSGRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADAVLLAPVYSAGENPIQGATSESLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAKRCPPSLAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.