PharMolix/UniProtQA huggingface dataset:
Protein: KVD20_HUMAN
Sequence: METPAQLLFLLLLWLPDTTGEIVLTQSPATLSLSPGERATLSCGASQSVSSSYLAWYQQKPGLAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 3D-20.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: HIS1_CROS5
Sequence: MITIALPKGALLSDSIELFKRIGLDFSSFLDSKNRQLQIIDPTNTAQGLLVRATDVPVYVEYGQAQLGIVGYDLLLEKSPDVAHLADLNFGGCRMSVAVPKTSPYQTPAELPPNGKVASKFVNCAKTYFQQLDLPVEIIPLYGSVELGPITGMSEAIVDLVSTGRTLKENGLVEVETLFHSTARLIAHPLSYRLNLDNLNDLSEQIKNSVSKS
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T132C_HUMAN
Sequence: MRSEGAAPGPAAPLCGALSLLLGALLGKVIEGHGVTDNIQRFSSLPPYLPVSYHILRAETSFFLKEANQDLLRNSSLQARVESFFTYKTRQPPVLNASYGPFSVEKVVPLDLMLTSNFLGPTNKFSFDWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDHGAGEKLPCLRVFAFRETREVRGSCRLKGDLGLCVAELELLSSWFSAPTVGAGRKKSMDQPEGTPVELYYTVHPGNERGDCAGGDFRKGNAIRPGKDGLEETTSHLQRIGTVGLYRAQDSAQLSELRLDGNVVIWLPSRPVKQGEVVTAYVTISSNSSVDLFILRAKVKKGVNILSAQTREPRQWGVKQEVGSGGKHVTATVACQRLGPSPRNRSSSLFNEVVQMNFEIASFSSLSGTQPITWQVEYPRKGTTDIAVSEIFVSQKDLVGIVPLAMDTEILNTAVLTGKTVAMPIKVVSVEENSAVMDISESVECKSTDEDVIKVSERCDYIFVNGKEIKGKMDAVVNFTYQYLSAPLCVTVWVPRLPLQIEVSDTELSQIKGWRVPIVTNKRPTRESEDEDEEERRGRGCALQYQHATVRVLTQFVSEGAGPWGQPNYLLSPNWQFDITHLVADFMKLEEPHVATLQDSRVLVGREVGMTTIQVLSPLSDSILAEKTITVLDDKVSVTDLAIQLVAGLSVALYPNAENSKAVTAVVTAEEVLRTPKQEAVFSTWLQFSDGSVTPLDIYDTKDFSLAATSQDEAVVSVPQPRSPRWPVVVAEGEGQGPLIRVDMTIAEACQKSKRKSILAVGVGNVRVKFGQNDADSSPGGDYEEDEIKNHASDRRQKGQHHERTGQDGHLYGSSPVEREEGALRRATTTARSLLDNKVVKNSRADGGRLAGEGQLQNIPIDFTNFPAHVDLPKAGSGLEENDLVQTPRGLSDLEIGMYALLGVFCLAILVFLINCATFALKYRHKQVPLEGQASMTHSHDWVWLGNEAELLESMGDAPPPQDEHTTIIDRGPGACEESNHLLLNGGSHKHVQSQIHRSADSGGRQGREQKQDPLHSPTSKRKKVKFTTFTTIPPDDSCPTVNSIVSSNDEDIKWVCQDVAVGAPKELRNYLEKLKDKA
What are the official names of this protein?
Transmembrane protein 132C.
What is the protein family that this protein belongs to?
Belongs to the TMEM132 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: 3L23_DENPO
Sequence: RTCNKTFSDQSKICPPGENICYTKTWCDAWCSRRGKIVELGCAATCPKVKAGVGIKCCSTDNCNLFKFGKPR
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Alpha-elapitoxin-Dpp2b, Alpha-EPTX-Dpp2b, Long neurotoxin 3, Toxin VN2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SULF2_HUMAN
Sequence: MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLGGSRALSNLVPKYYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAAQPRNLTKRHWPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHRGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG
What is the function of this protein?
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879).  It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879).
What are the official names of this protein?
Extracellular sulfatase Sulf-2, hSulf-2, Arylsulfatase, N-acetylglucosamine-6-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface.
Protein: DUT_WOLWR
Sequence: MQRSKIKVEIKRLSHGEDLSLPCYATVQSAGMDLYAALNDSAVLNPLERLLVPTGIVIAIPNGFEGQVRPRSGLAAKHGITVLNSPGTIDSDYRGEVKICLINLSNQPYEIKRGDRIAQILISPVSQVIWDDREEFCAEETGRNAGGFGSSGR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: MATK_NICAC
Sequence: MEEIQRYLQPDRSQQHNFLYPLIFQEYIYALAHDHGLNRNRSILLENPGYNNKLSFLIVKRLITRMYQQNHFLISTNDSNKNSFLGCNKSLYSQMISEGFAFIVEIPFSLRLISSLSSFEGKKIFKSHNLRSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYWNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYQGKSILASKGTFLLMNKWKFYLVNFWQCHFYLCFHTGRIHINQLSNHSRDFMGYLSSVRLNPSMVRSQMLENSFLINNAIKKFDTLVPIIPLIGSLAKGNFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GCNT1_HUMAN
Sequence: MLRTLLRRRLFSYPTKYYFMVLVLSLITFSVLRIHQKPEFVSVRHLELAGENPSSDINCTKVLQGDVNEIQKVKLEILTVKFKKRPRWTPDDYINMTSDCSSFIKRRKYIVEPLSKEEAEFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDTKSEDSYLAAVMGIASCFSNVFVASRLESVVYASWSRVQADLNCMKDLYAMSANWKYLINLCGMDFPIKTNLEIVRKLKLLMGENNLETERMPSHKEERWKKRYEVVNGKLTNTGTVKMLPPLETPLFSGSAYFVVSREYVGYVLQNEKIQKLMEWAQDTYSPDEYLWATIQRIPEVPGSLPASHKYDLSDMQAVARFVKWQYFEGDVSKGAPYPPCDGVHVRSVCIFGAGDLNWMLRKHHLFANKFDVDVDLFAIQCLDEHLRHKALETLKH
What is the function of this protein?
Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862).  The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity).  Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity).  Can also act on glycolipid substrates.  Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity).  Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity).
What are the official names of this protein?
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GlcNAcT, Core 2-branching enzyme, Core2-GlcNAc-transferase, C2GNT, Core 2 GNT, Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT-L.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Note=Also detected in the trans-Golgi network.
Protein: AROA_RHIE6
Sequence: MTRTAKLTIIPPGRPLSGRAMPPGSKSITNRALLLAGLAKGTSRMTGALKSDDTRYMADALRAMGVAIDEPDDTTFVVTGSGRLMPPKAPLFLGNAGTATRFLTAAAALVDGTVVVDGDEHMRKRPIGPLVEAMRTLGIDVSADTGCPPVTVRGTGRFEADRILIDGGLSSQYVSALLMMAAGGDRPVDIELVGEDIGALGYIDLTTAAMKAFGARVEKTSPVTWRVEPTGYRAADFVIEPDASAATYLWAAEVLSDGQIDLGVPNDAFTQPDAKAYETIAKFPHLPAEIDGSQMQDAVPTIAVLAAFNETPVRFVGIANLRVKECDRIRALSTGLNNIREGLAVEEGDDLIVHSDPALAGQTLPAEIDTFADHRIAMSFALAGLKIDGITILDPDCVGKTFPAYWRTLAALGVTYQGKD
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_ACTP7
Sequence: MNNLENIVEQLKRNRVVAYPTEAVFGLGCNPNNESAVRALLKLKKRPEEKGLILIAPTKELLLPYIDENKLTAAHWQIFETPSERAITWVMPAKKAVPQYLTGQFDTIAVRLCCIPAVIDLCERTGFALTSTSCNLTGQEPCRTADEVKLQFGADFPVLEAETAGKTNPSEIRDIFTQHIFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OGG1_ARATH
Sequence: MKRPRPTSQPSISSTVKPPLSPPVTPILKQKLHRTGTPKWFPLKLTHTELTLPLTFPTGQTFRWKKTGAIQYSGTIGPHLVSLRQRPGDDAVSYCVHCSTSPKSAELALLDFLNAEISLAELWSDFSKKDPRFGELARHLRGARVLRQDPLECLIQFLCSSNNNIARITKMVDFVSSLGLHLGDIDGFEFHQFPSLDRLSRVSEEEFRKAGFGYRAKYITGTVNALQAKPGGGNEWLLSLRKVELQEAVAALCTLPGVGPKVAACIALFSLDQHSAIPVDTHVWQIATNYLLPDLAGAKLTPKLHGRVAEAFVSKYGEYAGWAQTLLFIAELPAQKTLLQSFSQPINKLDESAEVNETSCDTLKP
What is the function of this protein?
Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues.  Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA.  Has a beta-lyase activity that nicks DNA 3' to the lesion.
What are the official names of this protein?
N-glycosylase/DNA lyase OGG1.
What is the protein family that this protein belongs to?
Belongs to the type-1 OGG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMA_BRUSI
Sequence: MSIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGLTRALLAQGAYVTAIERDDRCLEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIVANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERIVAKPDSDHYGRLGVLAGWRTQAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLKSIGGGALLEKTGIDGTRRAETLSVEEFVALANACLP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_PSET1
Sequence: MKLLIDVGNTSLKAKLWQNEQVQACDLNNLPWHAITHVIYACVGRSELLNAILAQAAFNSISCFEAKVTKTLGGLTCAYEHFNNLGIDRWLALIASFTLYPNKACIVVDAGTATTIDVLNCDGQHLGGWILPGLDLMTRSLTQNTQRVFDDENTPFTNQLGINTPNGLKNGALVATIGAINQAKPYLNDKNTQIIFAGGYGSLLQQQFKESIFDPMLVIKGLNYWYELDENSNKL
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP23_YEAST
Sequence: MNSSGDNAGFEWWRRTMQYKTGIGLTPEEKTRYEDDSKARELKKECLKCYEYRDWMLKYSPTVRFMVQAITKLNKGSDSKFDDSKIICDYCPDWKGGGFHPELGILLCQNRLRDKWHLEDTLSHELIHYFDDLKWQIDWLNLKHHACSEIRASSLSGECRFWEEFKRRGFRTGFHVARGHQDCVRRRAIISVSGNPNCQSKEHAAKIVDEVWDSCFADTRPFDEIYR
What is the function of this protein?
Has a dual role in the assembly of mitochondrial ATPase.  Acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side.  Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of ATP6 with the subunit 9 ring.
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Associates loosely with the inner membrane.
Protein: TTCA_VIBC3
Sequence: MTAQTQELTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDILMSLQKSAPISFELVAVNLDQKQPGFPEHVLPEYLDSLGVEYKIVEEDTYSIVQDKVPEGKTTCALCSRLRRGILYRTAKELGATKIALGHHRDDILETLFLNMFYGGKMKGMPPKLVSDNGEHVVIRPLAYCREKDIIKYSDMRGYPIIPCNLCGSQPNLQRQAVKQMLNDWDKRFPGRIETMFRAMQNVVPSHLADFSLFDFKSIDKNSGVINGGDIGFDKEEIAPQVVEDEDLVMEFDPSLQLNVTNI
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEB_SALPC
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TTL_BOVIN
Sequence: MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQDGIHPPLHSSRTDEREFFLASYNRKKEEGEGNVWIAKSSAGAKGEGILISSDATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQFNIYLYREGVLRTASEPYHMDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEAFNRYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAIASVFPPPDAEQQPPQPATFIKL
What is the function of this protein?
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
What are the official names of this protein?
Tubulin--tyrosine ligase, TTL.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
Protein: RA51C_CRIGR
Sequence: MQRELVSFPLSPTVRVKLVAAGFQTAEDVLGVKPSELSKEVGISKEEALETLQIVRRESLTDKPRCAGASVAGKKYTALELLEQEHTQGFIITFCSALDNILGGGIPLMKTTEVCGVPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVTLANACIQHLHLIAGTHKDEEHQKALEGFTLENILSHIYYFRCHDYTELLAQVYLLPDFLSNHSKVQLVIIDGIALPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDKNQALLVPALGESWGHAATIRLIFHWEQKQRFATLYKSPSQKESTIPFQITPQGFRDAAVTASSSQTEGSSNLRKRSREPEEGC
What is the function of this protein?
Essential for the homologous recombination (HR) pathway of DNA repair.  Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.  Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway.  Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks.  The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.  The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.  Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step.  Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation.  Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex.  Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR.  Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage.  Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3.  Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.  Involved in maintaining centrosome number in mitosis.
What are the official names of this protein?
DNA repair protein RAD51 homolog 3, R51H3, RAD51 homolog C, RAD51-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
Protein: MURD_TERTT
Sequence: MNGLLASDKYVVIVGLGATGLSVARYLHLRGERFSVVDTREHPPGADELMALNNKVDHHFGAVEQPQIDLLLNAAEIVLSPGVDRRTDFIQAALKNNISIVGDIELFLREVQVPVVGITGSNGKSTVTALMAAVGAKAGFKTCAAGNIGLPVLDALQENAELYILELSSFQLESVSRPGLTVACMLNVSEDHMDRYNRFVDYCMAKQRIYFGAQNVVYNIDDKLTQPPIVDGVARRGFSLSKPIEEGESAFYFSADTGNLCAAKDNLINIDQIKIFGRHNVANVLAVFAMADALNITRAATCAAVQEFSGLDHRCQWVAKKRGVTFINDSKATNVGAAQAAIAGLSASFKRILLIAGGDGKDANFFSFGKLVDAHVAVLILMGRDAGAIADCVSDTTPVVQAQTMTEAVEVAFSSAEEGDLVLLSPACASFDMFAGFEDRGRQFAAAVEGLTE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CHRVO
Sequence: MKASELKAKTVDELKAELLSLLKAQFALRMQHATQQLAKTSELKKVRRDIARVRTVLKEKAV
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: CH60_SALPA
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVAAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKIADLKGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKSDAPDLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF12_HUPLU
Sequence: MNLEVIAQLTVLALIVISGPLVIALSAARKGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.