PharMolix/UniProtQA huggingface dataset:
Protein: MAP1_MYCGA
Sequence: MIYIKNPNEIQKIKNAAQIYKKIVKQFNFDYIKNKSLKEIDQMLRDFVSQHHANSCYHGYLGFKGYHCLSLNQTIIHGLANDEIFTSKDKLTIDIGIELDNYYCDSAFTILGPDVNPRQKLLSEVTHNCIFELVKKIVPNQTTTNDLGIWTEEYAKKYGYSVIKDFGGHGCGIKIHEDPIILNYGTKKSSELLTPNMVICIEPMFFEKDNRYYIDPDDSWSVKPVNKNQYVCHWEHMVLIKEDQAEILTL
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: TBCEL_MOUSE
Sequence: MDQPSGRSFMQVLCEKYSPENFPYRRGPGVGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLQDWHEVSKIVSNVPQLEFLNLSSNPLSLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPELEELFLCLNDYETVSCPSVCCHSLKLLHITDNNLQDWTEIRKLGVMFPSLDTLVLANNHLNAIEEPADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVVARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLAEVDLRPQSSAKVEVHFNDQVEEMSIRLDQTVAELKKQLKTLVQLPTSSMLLYYFDHEAPFGPEEMKYSSRALHSFGIRDGDKIFVESKTK
What is the function of this protein?
Acts as a regulator of tubulin stability.
What are the official names of this protein?
Tubulin-specific chaperone cofactor E-like protein, Leucine-rich repeat-containing protein 35.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ACYP_THEKO
Sequence: MKRVRAHLRIYGRVQGVGFRWSMSREARKLGVHGWVRNLPDGTVEAVIEGDPERVEALIGWAHQGPPLARVTRVEVKWEEPEGLEGFKVVG
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: Y3560_ALTMD
Sequence: MIIIDDLLTKDEVTQFRQQLASVPFNDGKSTAMGMAAGVKNNGQADAQDSRVQQLANALLSKLGNNPTVISGALPQRIFPPCFNRYSESQTYGYHVDAAIMRIPNTPDVLRSDMSMTVFLTPKEDYEGGELVIQTGFGEQKVKCDAGSAILYPSSSLHKVTPVTKGERIAAITWIQSMVSDQQMRETLFQLDQSIQSLVNVGTAEREQLDGLHHVYHNLVRKFSQV
What are the official names of this protein?
PKHD-type hydroxylase MADE_1018490.
Protein: SIR2_CANGA
Sequence: MIISRGSHVDEEPVAKKPRISVGEMTDDTTDDGLNTEEIRAPYTTEEMDEPEKAALLPKIPKKSPVSIGMNPENGKYVLPNYSKDESLNARKFLKYYGLRKFLDTYLPEELNSLYIYSLIKLLGFEIRDKELLSSLYRFFHPVKSSDQFKLEYEDFTDPLEKKEAVKLIKDLQKAINRVLATRIRLSNFYTIDHFVSKIKKAERILVLTGAGVSTSLGIPDFRSSEGFYSKIQHLGLDDPQDVFNYDIFMQDPSVFYNIAHMILPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPEKLVQCHGSFATASCVTCHWQIPGEKIFSNIRSMELPLCPYCYQKRREYFPNTGDEEYDTLKGNLESGIQNNNFALKSYGVLKPDITFFGEALPSKFHKTIREDIMKCDLLICIGTSLKVAPVSEIVNMIPAYVPQVLINKDPVKHAEFDIELLGFCDDVATVVAQKCEWDIPHKDWEGKLKKKRFDVNEIERGVFNIEAGSPE
What is the function of this protein?
NAD-dependent deacetylase.  Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span.  It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4 (By similarity).
What are the official names of this protein?
NAD-dependent histone deacetylase SIR2, Regulatory protein SIR2, Silent information regulator 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL20_OLEA2
Sequence: MRVKRGMATHRRHKKYLKMAKGYRGGRSKLYRTAREAVERSLAYSTRDRKVRKREFRKLWILRINAAARENGVSYSKFIHGLALAGIELNRKVLADLAVREKEDFAKLAELVKSKLS
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ATPL_STAEQ
Sequence: MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIGVVIAFMTFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AHBB_DESVH
Sequence: MSRYDDFTEVERAILRIVQSNLPDSLTPYADIAREVGTDEETVLALLRSLKEEGPIRRFGASIKHQRAGWNHNAMVAWKVDPAIVEEAGTKAAEHPHISHVYYRPSSAPDWPYELYTMIHGRHATAHMDVIEQLRRETPLEEFAVLESLRELKKTSMTYF
What is the function of this protein?
Involved in siroheme-dependent heme b biosynthesis.  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme.
What are the official names of this protein?
Siroheme decarboxylase beta subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.
Protein: MURD_CLOBA
Sequence: MKEDFKKFKEFIYKKRVGVVGIGVSNIPLINFLIKLGAEVTAFDKKTEEELGEVSSDFKNKGVNLELGDNYLDKLTGFDVVFKTPSMRIDSECLVKVKKEGAYVTSEMEEFVRYCKAKIYGITGSDGKTTTTTIISKILQEEGYKTWVGGNIGTPLFAQIEEIKAEDRVVLELSSFQLMTMNLPMDIAVCTNLAPNHLDMHKDMQEYIDAKKNIFLYQGSTNTLVVNRENEITYGFEAEAKGEVREFSSKREVKEGAYYKDGILYLSGKEVCKKDNIVIKGMHNVENYLAAFIATKDDVSIENMKKVAESFNGVEHRCELVREINGVKYYNDSIASSPNRTLAGLKAFDKKVILIAGGYDKHLLFEPLANEGYPYIKELILLGQTKEKIKDVFKDLEASKGIKINISEVSTLEEAVKKAQDLAKQGDIITLSPACASFDMFPNFMIRGNKFKEIVNEL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLT13_RAT
Sequence: MRRLVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKTLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLSGPVIMLKCHHMRGNQLWEYDAERLTLRHANSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (By similarity).  Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (By similarity).  Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (By similarity).  Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar.  Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC.  Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity).  May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 13, Polypeptide GalNAc transferase 13, GalNAc-T13, pp-GaNTase 13, Protein-UDP acetylgalactosaminyltransferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: KGUA_NEIG1
Sequence: MSAYRKGNIFIISAASGTGKTTLVSRLLANHNGLRVSVSHTTRPPREGEANGVHYHFVSKEEFESLIAQEAFLEYADVFGNYYGTSTEGVNALAAAGYDVILEIDVQGAAQVRNALPEAVGIFILPPSFDVLAARLKGRGTDSREVIQRRLSKARHEIEQSVLFDFVVVNDDLEKAEGDLLHIVNACRLKRSRQLGFIADLLENS
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSG1_AVESA
Sequence: MATTRFPSLLFYSCIFLLCNGSMAQLFGQSFTPWQSSRQGGLRGCKFDRLQAFEPLRQVRSQAGITEYFDEQNEQFRCAGVSVIRRVIEPQGLLLPQYHNAPGLVYILQGRGFTGLTFPGCPATFQQQFQQFDQARFAQGQSKSQNLKDEHQRVHHIKQGDVVALPAGIVHWCYNDGDAPIVAVYVFDVNNNANQLEPRQKEFLLAGNNKREQQFGQNIFSGFSVQLLSEALGISQQAAQKIQSQNDQRGEIIRVSQGLQFLKPFVSQQGPVEHQAYQPIQSQQEQSTQYQVGQSPQYQEGQSTQYQSGQSWDQSFNGLEENFCSLEARQNIENPKRADTYNPRAGRITHLNSKNFPTLNLVQMSATRVNLYQNAILSPYWNINAHSVMHMIQGRARVQVVNNHGQTVFNDILRRGQLLIIPQHYVVLKKAEREGCQYISFKTTPNSMVSYIAGKTSILRALPVDVLANAYRISRQESQNLKNNRGEEFGAFTPKFAQTGSQSYQDEGESSSTEKASE
What is the function of this protein?
This is a seed storage protein.
What are the official names of this protein?
12S seed storage globulin 1.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
Protein: CTPF_MYCBO
Sequence: MSASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFGPNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVGFIQESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQTGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVATGAETELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVETFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADKTGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGACSNDAALVRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYMATLHRDGTDHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVLATGMGAGAGTPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITGDHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTTAIALGLMLAFEPKEAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNGAGLHEARTAALNLFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFAITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP
What are the official names of this protein?
Probable cation-transporting ATPase F.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDH_HYPNA
Sequence: MARNKIALIGSGMIGGTLAHVAAREELGDVILFDIAEGLPQGKGLDIAESTPVYGASVNLKGVNDYAGIAGADVCIVTAGVPRKPGMSRDDLLGINLKVMKAVGEGIKAHAPNAFVICITNPLDAMVWALQKFSGLPTEKVVGMAGVLDSSRFAYFLSEKTGVSVADIHAWTLGGHGDDMVPMVRHSTVGGLPLTQLVAQGWMSQAELDAIVERTRKGGGEIVNLLKTGSAYYAPAESAIAMAKSYLADQKRVLPVASYCSGQYGLKDMYVGVPTLIGAGGAEKIVEFDFNADEKAMFDKSVASVNGLIEACKGIDPSLA
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: CAER4_XENBO
Sequence: MFKGILLCVLFAVLSANPLSQPEGFADEEERDVRGLASLLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAGLKIGTHFLGGAPQQREANDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVHERDVRGFGSFLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRNGEDD
What is the function of this protein?
The pharmacological activities of caerulein are quite similar to the physiological activities of gastrin and related peptides.
What are the official names of this protein?
Preprocaerulein type-4, Preprocaerulein type IV.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF1_GLUDA
Sequence: MSKEDMIEFSGTVTELLPNAMFRVKLDNEHMILAHTSGKMRKNRIRVLAGDRVNVEMTPYDLSKGRITFRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFA5_YARLI
Sequence: MNRAAFRQALRIVFPGVILGLLGYGTYAYCYILCWNLYHHMGYRAGLALLIVYCILKTLVFIYWAAVVIVGPGKVTGVSPLQIFIPGSEVVDEKAQAIVSRQINPKLPDTYICDGWGMPKWCSECQTHKPDRTHHSAIVGHCVPKMDHMCFWVGTVIGQHNYKIFLQYTTLFSTYLIYTLVTTAVFTPRMGQYRRDRGAPDSIPNGNIIALLILTGAWAAFCTSVCLQSFWGVCRNLTAMEGLGRKQGDMVLVNFRYEGKRIIQPLREEDPLPFDQGFAKNWRQVFGTNPLIWFLPFPVVPAAEDYFSNAYGQKFLERIPARWLEGDGREMAAV
What are the official names of this protein?
Palmitoyltransferase PFA5, Protein fatty acyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LYS1A_LUCSE
Sequence: MKFFIVLLAALALFTPAFGKTFTRCSLAKEVYALGVPKSELPQWTCIAEHGSSYRTNVVGPTNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLSCNDLLTDNISNSVKCARKIKSQQGWTAWSTWKYCSGSLPSINDCF
What is the function of this protein?
Shows antibacterial activity against Gram-positive bacterium M. luteus but shows no activity against Gram-negative bacterium E. coli (PubMed:25098233).  Likely to play a role in the eradication of ingested pathogens during their passage through the intestine (Probable).
What are the official names of this protein?
Inactive lysozyme 1A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXB_ENT38
Sequence: MVDNRPLTIALVAGETSGDILGAGLIRALKAREPNARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTGRFTDLKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTDMVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLDPDKNAARDSLGIPHDAHCLALLPGSRGAEVEMLSADFLRTAQILRQTYPDLEVVVPLVNAKRREQFERIKAAVAPDLHIHLLDGKGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQDECQPQALADALLPLLADGKTRHQMHDTFRELHQQIRCNADEQAADAVMELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: PURL_PROM1
Sequence: MTVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGVMWSEHCCYRNSRPLLKNLPTTGSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNISLLEGVVAGISHYGNCVGVPTIGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFASSELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASKGEVGIELNLDLVPAREKGMTAYEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVGKVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINSTPEYLQEHWKWTEDLLPKTLDNGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIRSQNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLNFSSPDKPVGFWQLSMSCEGITKACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGMVGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERISLSASSFLEYIHGLKTGRPPEIDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLDRLLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNTIIDVNILDLKDTYKDAIHKKITK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA2_BORBR
Sequence: MFNRNLTLDQVDPDVWAAIQKEDVRQEQHIELIASENYASPAVMQAQGTQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRLKQIFGAEAANVQPNSGSQANQGVYMAVLKPGDTVLGMSLAEGGHLTHGASVNASGKLYNFVPYGLDADEVLDYAQVERLTKEHKPKLIVAGASAYALHIDFERMARIAHDNGALFMVDIAHYAGLVAGGAYPNPVPHADFVTSTTHKSLRGPRGGVIMMKAEFEKAVNSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFQDYAQQVVKNAKVLADTLVKRGLRIVSGRTESHVMLVDLRPKGITGKEAEAVLGQAHITVNKNAIPNDPEKPFVTSGIRLGTPAMTTRGFKEAEAELTANLIADVLDNPRDEANIAAVRARVNELTARLPVYGN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAZA2_ORNAN
Sequence: MADVEDQLSDDEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNVDQFTPVKVEGYDEQVLITEHGDLGNGKFWDPKNRVSFKFDHLRKEATDPRPQEPENAVESWRHSVETAMRAYVKEHYPNGVCTVYGKTIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAINENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: RS5_CHLTR
Sequence: MTLSRNSHKEDQLEEKVLVVNRCCKVVKGGRKFSFSALILVGDRKGRLGFGFAKANELTDAIRKGGDAARKNLVSINSLEGGSIPHEVLVNHDGAELLLKPAKPGTGIVAGSRIRLILEMAGVKDIVAKSLGSNNPMNQVKAAFKALLTLSCKDDIMKRRAVIND
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LEU3_BACCZ
Sequence: MEKRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESETAHLSPLKKADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAISAVLKSGKCTEDIGGTETTTSFTKAVMQEMEEQALVGRGR
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_ECOLC
Sequence: MTSSYLHFPEFDPVIFSIGPVALHWYGLMYLVGFIFAMWLATRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPQFMADPLYLFRVWDGGMSFHGGLIGVIVVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFPFAMLFPGSRTEDILLLQTNPQWQSIFDTYGVLPRHPSQLYELLLEGVVLFIILNLYIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIVAGVIMMVWAYRRSPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDK_BRUSU
Sequence: MAIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HASA_STRPY
Sequence: MPIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNLERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
What is the function of this protein?
Glycosaminoglycan synthesis.  The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant.
What are the official names of this protein?
Hyaluronan synthase, Hyaluronate synthase, Hyaluronic acid synthase, HA synthase.
What is the protein family that this protein belongs to?
Belongs to the NodC/HAS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR9_PROM9
Sequence: MSPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAKRTDEEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSIENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKGELKDSYKAQLALEAFQHTADYDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKDLSYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALECDSVSAFGGIVAFNSNVDSETAINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKDQLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNPSNQMNLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYGIKAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.