PharMolix/UniProtQA huggingface dataset:
Protein: PIM2_HUMAN
Sequence: MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
What is the function of this protein?
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.  Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD.  Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.  The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis.  Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway.  Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1.  Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT.  Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B.  Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
What are the official names of this protein?
Serine/threonine-protein kinase pim-2, Pim-2h.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Protein: NCZS_STRML
Sequence: AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
What is the function of this protein?
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors).  NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic.  The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
What are the official names of this protein?
Neocarzinostatin, NCS, Mitomalcin, MMC.
What is the protein family that this protein belongs to?
Belongs to the neocarzinostatin family.
Protein: EAF_SCHPO
Sequence: MKQKETKTSQIALVDGEKLSITDSFASLFTLDEEEENDSVDNEEIKLTKEKHEKLLLLFWLHCKFPNGLEWLHSSSDLLPEQVSEWFNFYQKYRFKRGRNFNLSARESVTPIVEEPIVPEEPDNLEGVSEETPLKETSLELSEEEIITSKSPIPSPETIHKNIDVEEKETIEPTTPVKEVETTAHAEEEKGPLTPDSEYAARQLTEELANKSSQEEGVDKQLRVVEATEKEHEEDGNEENVTVTKPVEVATDQVESKEVKKKEVSETTEPTAPPVTVAEVLEIEDKVPKVDEVEEVHSPEAKVTENDVENVQSGIDIEKTIQLLNNQEIPSEQQIISVDKATESPVQEVAVDVNEKPVDEIVEPSKLQMENKLPSEKSPTIDRTGVEAPLFELSVSMPLTLIPPSKFSEPVKPELSSEAWLLRTEMSPLHLRLKNAHKYVLSDNWSHAYREEIVRQSLHHLTVAKEKGIWSFRQPKRQNEMPRLKTHRDYVLDEMQWMSIDFSQERKWKIILAHRMANWVMDYHQASDKCTVCTPASLSKNKKPYMQENEHQKDSHEETFNEQIVSHFNLNDNNNNKVLSIPRDSLQFYNAVFSDDIFVTTNSEQIQNCVLNVPMYGPPTENNEYCEEISEKYPITPVSRFAYAKTKLKSTCAKASRKRLFNQLELSPPESFMEKKARSDENQLDGNKIKDDNQKLSSVGTFSVRPPYPPSSKDIRPEAPWLPEEDELLLLLLRRYSFNWEFVASRLTPPGLYIPLAEKRTAWDCFERWIQVDPRAANVQLTGSHARLAQQKLDESLRHSDKVSQHLSLRDEGTPNHLIKHNSYFLLPTVSRHYRPITIFEAIRKILKKREFAKKPTMTKRAIAPSAASTEKLPPVPSPLELSRLKSEREAQIQQIQAQRNFAQLQSQNRALRPQNAAVAAGAQQHNQQLAAFQAVAASQNSSNNSSAGVSPIAGRMVPRLQPYAVSSSLKLTPEQIHQLQQRKQTVPTTERTQ
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein vid21, Esa1-associated factor vid21, Vacuolar import and degradation protein 21.
What is the protein family that this protein belongs to?
Belongs to the EAF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAD_PARPJ
Sequence: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRNKKPFFTLEERLDIAHEVLGHYPNVQVMSFKGLLKDFVRTNNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMDPASGASAGQP
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYOX_BACLI
Sequence: MRKRYDTIVIGGGIIGTSIAYHLAKAGKKTAVFESGEVGKKATSAAAGMLGAHAECDKPGTFFEFARASQKAYKRLTGELKDISGIDIRRHDGGILKLAFSESDREHLMQMGALDSVEWLEADEVYKLEPNAGKGILGANFIRDDVHVEPAAVCRAFARGARMLGADVFEYTPVLSIESEAGAVRVTSASGTAEAEHAVIASGVWSGALFKQIGLDKRFYPVKGECLSVWNDGISLTRTLYHDHCYIVPRHSGRLVVGATMKPGDWNEQPELGGIEELIRKAKSMLPGIESMKIDQCWAGLRPETGDGNPYIGRHPENDRILFAAGHFRNGILLAPATGEMMADMILGNPVKTEWIEAFKAERKEAVHR
What is the function of this protein?
Catalyzes the FAD-dependent oxidative deamination of glycine, leading to glyoxylate, ammonia and hydrogen peroxide (PubMed:26920475).  Is also able to act on various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide (By similarity).  Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine), and thus may be involved in the degradation pathway that allows B. licheniformis J33-8 to grow with glyphosate as the sole source of carbon (PubMed:26920475).  Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (By similarity).
What are the official names of this protein?
Glycine oxidase, GO, BliGO.
What is the protein family that this protein belongs to?
Belongs to the DAO family. ThiO subfamily.
Protein: DCUP_SACD2
Sequence: MTVLKNDRFLRALMRQPVDQTPVWMMRQAGRYLPEYRATRAQAGDFMGLCTNPERACEVTLQPLERYPLDAAILFSDILTIPDAMGLGLYFETGEGPKFKKTISTAADIEKLEVIKPLQDLPYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFQKTKALIYNHPEAAAQLMDKLADSVIAYLNAQIDAGAQAVQIFDSWGGALSHDAYKTFSLAPMAKIVKGLKRENEGRKVPVILFTKGGGQWLEAMADAGADCLGLDWTTDIGQARARVGDKVALQGNMDPSILYASPDRIREEVARILASYGAGTGHVFNLGHGITPGVDPEHAGAFIRAVGELSAQYHK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELAV3_XENLA
Sequence: MVTIISTMETQANNGPGCVGILNGTNGEADDSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSSLPKTMNQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGASEPITVKFANNPSQKTGQALLTHLYQTTARRYTGPLHHQTQRFSPLSILPRFSPITIDSVTNLAGVSLTGPTTAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKQHKA
What is the function of this protein?
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs.  May also bind poly-A tracts via RRM 3.  May be involved in neuronal differentiation and maintenance (By similarity).
What are the official names of this protein?
ELAV-like protein 3, Protein ElrC.
What is the protein family that this protein belongs to?
Belongs to the RRM elav family.
Protein: ATL_STAAU
Sequence: MLGVINRMAKKFNYKLPSMVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTEQAKAEVKNPTQNISGTQVYQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATTNNTQPVAKSTSTTAPKTNTNVTNAGYSLVDDEDDNSEHQINPELIKSAAKPAALETQYKAAAPKAKTEATPKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEEDYTSYFPKYAYRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIETAPTDYLSWGVGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEYDGNGTVWTHYAVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQFTTTPTTPSKPTTPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAVSKTATLGNQKFYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKSGTKLYTVPWGTSKQVAGSVSGSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPIPKPSTPTTNNKLTVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKFYLVKDYNSPTLIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSGTGNQTFKATKQQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTKPQTTQTVSKIAQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTSHNIPLGWFNVKDLNVQNLGKEVKTTQKYTVNKSNNGLSMVPWGTKNQVILTGNNIAQGTFNATKQVSVGKDVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYYVTPNSDTAKYSLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQTGMTLNQVAQIQAGLQYKPQVQRVPGKWTDANFNDVKHAMDTKRLAQDPALKYQFLRLDQPQNISIDKINQFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGADVVNNKVVTNSNTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVKAGQNTLYKMRWNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK
What is the function of this protein?
Endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure.  One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.  Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells.  Acts as an autolysin in penicillin-induced lysis.
What are the official names of this protein?
Bifunctional autolysin.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted, and then anchored on the cell surface at the peripheral cell wall above the completed septum (septal region), for the next cell division cycle.
Protein: RL15_CLOTE
Sequence: MKLHELRPAEGSRKSPKRVGRGTGSGLGKTSARGENGQNSRSGGGVRPGFEGGQMPLYRRLPKRGFTNIFAKKYTAINIDRLNIFEDDTVVTPELLIEKGVISKVYDGVKILGNGELDKKLIVKATKFSKAAAEKIEAAGGKVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL6_STAMF
Sequence: MVKLPHIYEEIDIPENVTVEINGLKVKVNGPKGSIERDFSHVRNIILRKENSKIIVETFFADRRKKALVGTIASHIENMIKGVLKGYRYKLKIIYSHFPITVEVDDRNRIVRIKNFLGEKSDRIAKIIGEDVKVTVKGEDIIVEGIDIEHVGQTAANIELATKVKDKDRRVFADGIYIYDWGEEE
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RBSD_BACVZ
Sequence: MKKHGMLNSHIAKVLADLGHTDLIAIADAGLPVPDGAPKIDLSLTAGVPAFRDVTSLVAGEMAVEKVIAASEIKDANPENASFIESHFSAQTIEYMSHEEFKRLTQKAKAVIRTGEMTPYANCILQAGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_THIDA
Sequence: MGQKIHPIGFRLGVQRIWTAKWYGSNRNFSDTLLEDIKVRDYLKKKLSHASVSKVLIERPAKNARITIFSGRPGVVIGKKGEDIEVLRGELARLMSVPVHVNIEEVRKPETDAQIVADGIAQQLEKRVMFRRAMKRAMQNAMRLGAQGIKIMSSGRLNGAEIARTEWYREGRVPLHTLRAEIDYGFAEAKTTYGIIGIKVWVYKGDALTRGEQPAAAEQEKRGKKSGVKHAAAS
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DHR11_BOVIN
Sequence: MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGLARPDTLLSGSTSGWKEMFNVNVLALSICTREACQSMRERKVDDGHIININSMCGHRVPPPAETHFYSATKYAVTALTEGLRQELREARSHIRATCISPGVVETQFAFKLHDKDPEKAAATYEHMKCLKPEDVAEAVIYVLSTPPHVQIGDIQMRPTEQVT
What is the function of this protein?
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites.  Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids.  May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 11, 17-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Estradiol 17-beta-dehydrogenase, Short-chain dehydrogenase/reductase family 24C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP123_MYCTU
Sequence: MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
What are the official names of this protein?
Putative cytochrome P450 123.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ACCA_BRUA1
Sequence: MYNYLDFEKPVADLEGQILELKKLAQEQGSVEMGDEISRLEKRSADALKDIYRKLTPWQKAQIARHPDRPHCLEYIDRLFTEFTPLAGDRKFANDEALQAGFGRFNGTPVAIIGQEKGSDTKTRLKHNFGSARPEGYRKAVRIMEMADRFQLPLITFVDTAGAYPGVSAEERGQAEAIARSTAECLKLRVPVISIIIGEGGSGGAIAIAVANRVYMLEHSIYSVISPEGAASILWHDSTRAKDAASNMRITAQDLFDLKIIDGIIPEPLGGAHRGKESVIDAAGDIIAASLRSMKDIDGETLKQERRQKFLEIGRNI
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_AZOVD
Sequence: MSKRAFNFCAGPAALPTAVLERAQAEFLDWQGKGLSVMEMSHRSDEYVAIAAKAEQDLRDLLGIPSNYKVLFLQGGASQQFAEIPLNLLPEGGVADYVDTGIWSRKSMEEARRFGTVNVAASAKAYDYFALPGQNEWRLSKDAAYLHYASNETIGGLQFDWVPETGEVPLVVDMSSDILSRPIDVSRFGLIYAGAQKNIGPSGLVVVIVREDLLGRARSVCPTMLDYKVAADNGSMYNTPATFSWYLSGLVFEWLKEQGGVEAMAQRNRAKKDLLYGFIDGSGFYTNPIAVDARSWMNVPFRLADEKLDKPFLAGAEERGLLNLKGHRSVGGMRASIYNAVGLDAVEALVAYMAEFEKEHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_DICTD
Sequence: MLKVGIVGASGYVGLELTRILLRHPQVDKLYLFSDHFEDSWVFKSEKIFITDRSTYSELYKDLDVVFFALGSGETLGFLSKGEIPERFIDMSADFRFKNPGEYERVYGIKHNMPEILEKVVYGLPEIFRDKIKGAQYIANPGCYPTASLLGLFPLIKNNLTYGNAIIDAKSGISGAGRKPTDKSIYGNIAENYQAYSILNHRHQPEIENVIKEIGYLRVLFVPQLIPVFRGMFVSIYVPLRDEITSEDLYQIFKEVYEDEYFIKVLPPSCSPEIKKVRGTNWAVISAQADKNTKNAVILVAIDNLIKGAAGQAIQNMNIMFGFAESLGLDFLPLYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_HALS3
Sequence: MSLGDSDRERVVAALGRDPTPAEAALFENLWSEHCAYRSSRSLLSAFDSDSEAVVVGPGDDAAVVRVPGTDQLVTVGVESHNHPSYVDPYDGAATGVGGIVRDTLSMGAYPIALADALYFGDFDDEHARYLLDGVVEGISDYGNAIGVPTVAGATQFHDGYTGNPLVNVACVGLVTEDRLVTAAAKSPGNKLVLVGNATGRDGLGGASFASEDLAEDAETADRPAVQVGDPYTEKLLIEANETLLDRDLVVAARDLGAAGLGGASSEMVAQGELGARITLDAVHQREPEMNAMEILLAESQERMCYEVAPADVDAVREVATRYDLGCSVIGEVTTGNYVCEFDGETVVDAPATVLADGAPATDQPSTVPQAPATDRPDPALGTAIDAVLSAPNTASNEWVYRQYDHEVGARTVQRPGEDAAGLALHEADDGTTVALSAGANPGWTACQPYAGAYATAVENATNLAAAGAEPLAAVDCLNGGNPEDPDVYGGFEAMVAGLADGCRAIDTPVVGGNVSLYNDSATGPIAPTPTLAVVGYRDQHPVPGSGLAGDGDLVLVGGHADGLGGSVYLQALGGTDQFPAADAAGVDAVREAATRADTLAVHDISDGGLAVTLAEMVTADAGATVTVPGLAALFSECPGRAVVETRDADALQAALDVPVVRLGSATTDGTLSVTVDDETVTRDAATIRDHRGVIARELD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKB42_ARATH
Sequence: MDESLEHQTQTHDQESEIVTEGSAVVHSEPSQEGNVPPKVDSEAEVLDEKVSKQIIKEGHGSKPSKYSTCFLHYRAWTKNSQHKFEDTWHEQQPIELVLGKEKKELAGLAIGVASMKSGERALVHVGWELAYGKEGNFSFPNVPPMADLLYEVEVIGFDETKEGKARSDMTVEERIGAADRRKMDGNSLFKEEKLEEAMQQYEMAIAYMGDDFMFQLYGKYQDMALAVKNPCHLNIAACLIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKAIRRELRALAEQEKALYQKQKEMYKGIFKGKDEGGAKSKSLFWLIVLWQWFVSLFSRIFRRHRVKAD
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake.  Regulates cell elongation and orientation.  Functions as a positive regulator of PGP1-mediated auxin transport.  Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1.  Required for the proper localization of auxin-related ABCB transporters.  Plays a role in brassinosteroid (BR) signaling pathway.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP42, PPIase FKBP42, 42 kDa peptidyl-prolyl isomerase, FK506-binding protein 42, AtFKBP42, Immunophilin FKBP42, Protein TWISTED DWARF 1, Protein ULTRACURVATA 2, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein. Vacuole membrane; Single-pass type IV membrane protein. Endoplasmic reticulum.
Protein: KPYK_STAAS
Sequence: MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PEP-utilizing enzyme family.
Protein: MIH_PROCL
Sequence: RYVFEECPGVMGNRAVHGKVTRVCEDCYNVFRDTDVLAGCRKGCFSSEMFKLCLLAMERVEEFPDFKRWIGILNA
What is the function of this protein?
Inhibits Y-organs where molting hormone (ecdysteroid) is secreted.  A molting cycle is initiated when MIH secretion diminishes or stops (By similarity).
What are the official names of this protein?
Molt-inhibiting hormone, MIH.
What is the protein family that this protein belongs to?
Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAAB_SULIK
Sequence: MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLRKNEAEKIKAYLSNVLPNLIVVDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFNAKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFESDGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLCSLDERSNGKYSIAIRAVITEDFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKPPATIEFE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: NUOB_BACC1
Sequence: MVINFEELHPNERAELERNIFFSTLEQLKGWARSNSLWPMTFGLACCAIEMMGVGSSHYDLDRFGSFFRTSPRQSDVMIVSGTVTKKMAPIVRRLYDQMPEPKWVIAMGSCATAGGPYVNSYAVVKGVDQIVPVDVYIPGCPPNPAALIYGINKLKEKIRYEAKTGKQVTNK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.