Protein: FAS2_USTMA
Sequence: MDASRLSRSSSTSFTSVLSPFEPASVAVSAHGSPPSSASPGPDDKAFSVDGTQTPPHQLGVVLITSPFNSEVTVSLSVPIRDFLDRHNLVQVRDEFVNHLRSLLASSPGQEPAIDSVALLVHLLLYLAENLSSAEHRPRHARLSLLEAAWASFHSENLDSVDVHTFARSLSPEKASLVLRAHFEAYAALQQSGISVAIRVPALLQSVQKRQAGLYALFGGQGNNHGYFSELQTLFDTYRPLVEPIVAAATARFSHLLSRIDAARSGPYAFHSQGLDVLAWLQRRTDRPTEAYLASVPISGPLLSLTQLIQFYVAAKSSGMTVPQFRSHFEAVSGHSQGIVSATAMAMAIDDEHYIECVAMAAEFLFQIGSVSQLCYGDRTVSDETSMESVEAGFGPPSSMLVISAPSRAFIEVRVALFNTIVPEHRRIHAALINAPTTAVLAGHASDLVSFARDVSAISAPAKLDQARIPFSKRKPSLRLKFLPISLPYHSPLLADVTLSQVLAPIDAQKWQAHPLALPVHSTTDGANMQQLPSSSILDSLRVQMCTAPVDWIQAVQPSATITHFVDFGTGGASGIGNITARNLSGRGFKVLTVSGTHKESAEFYRLDPTPNAQPWGSKFQPRLLRTPQGKVILDTPMSRLLGKPPIMVAGMTPTTVQASLNAATIQAGYHIELAGGGLHDESKLRSRVQEILAKAPAASGLTLNSLYINPRQWSFQLPAWLQLSREGAPIDGLCVAAGIPSPDKAQELLTSLKQAGLRHVSFKPGSLDGIKQVCKIAQQNPGFPILLQWTGGRAGGHHSAEDFHDPIIHSYEIIRSCPNLVLVAGSGFTSADSFWPYLSGQWSVKRGLPPMPFDGVLFGSWAMTAKEAATSLPVKQLIASTQGCSDKDWQKTYDAPIGGIMTVLSEMGELVHQVANRATLLWSELDRDLFKLSKDKQLVYLAKNKERLVQRLNDDFQRVWFARDGQGKILYDVQDMTYADVADRMLSLMFIAAQARWIDLGYRNLLGDWCRRIEERFSKASKTYQLQSYAQFDRSPELELHRLLDHYPDCKTTLLTSEDVEYFHTMCWRRGQKPPPFITRLGEDFGHQFKKDSLWQSEDLDAVVDADPQRVCILHGPVAASDTAPVDQPIAEMLGSVEKGLVQHVLDHFYKGDLNNVPVAEYLDATATGSPAVRTSPIRTVCSRIKIDSGEHVAVFSVNSSAVKNPVAFLDSVVGEQPSWIRALVHSSRVSLGRQLRSNPLQRLLALREGQLFQIHTSVDGHNVKRLQVYGCHRSYGEQSNDFLAVDIVRRSDTKTSSGADIDVFIYEQRGSEAIPLLLQFEYTPSTSCALIREVEHGRNDRIRRFYWKMWFGEDMPADAQLDRVSSFTTEPRPVSSAQIPDGGAIAVDPTISAGWEAIMKTVVSSCDADLLSLVHLGHEFQTIGGALPVASGDICSVRSYASSITNSETGKILTVKATISRVEAAGSDAVPVVQVTSRFFYKGKYADHHRCFTETDFAFLLVLQDEAAVQVFKSKDWLELDQGVHEVKVGTELILRGTTVVPRYKNAKEMLDLRVQGAVFVRQGVEENQIGLIEFDADAPLSSDPIVAYLERHGTRLQNANEYSTVPISNAYKLAEGVLTTPKTNEPYSRASLDFNPIHINPYFANLAELPATIGHGMSTFAECQKWMDEAMKSTEPHNKTTVPSCTAFKADFTAMVVPGDQLSVQLRHKAMSDGQKVVQIDASNQRGELVLQGTARYQQPRSVYVFTGQGSQAKVMGMELYRQSATARAIWDEAEQHLAQSLGLSILEIVRENPKTKTVYFGGAQGQSIRRNYMALQHETIDEQGRSIRTPIFPSIHANSRSYTFESPKGLLFATQFTQIALVLFELAYFRHLQKEGIIVEDAVFAGHSLGEYAALASVAGMMRLRDLVDVVFYRGLTMQSAVPRINGRSDYGMVAVAPIKAFPKINDVDAALAQVVDRVSQASGQLLQTVNYNVRRQQSVVAGHEVALAALSRVLDKCGSKALSVANEAELVAEVTSAVEAAQSTAKTSGIELKRGIATIPLAGIDVPFHSKFLSNGIDPFRRFLDSRLDIETVRPEALVGRYIPNLVARIFTLERAYIEHVSEVTRSEVLANILANWDEALLDRRRLTRTLVIELLAYQFASPVLWSQTQTLLFQDASFERLIEFGPTPTLVGMASKTLAADFSEKDRKLGLKRTLLCVGKNDADILYSFEAEEEVNPTDSPKATPEPAVSKAALAAAATPAVAAATTAVAQVAAPALDDERLDPLLTVRSILAQKQKVKIADIPPSKSIKQLTGGRSTLQNELVGDLGAEFVELPERAEELTLEELAAALRPGYSGELGKYTNGLIARLSASKLPGSFGLTALKAHLTARYGFQSGRISAILLYTLTEEPAKRLTGDAEAISWIDGVAAVYAKDTSITLPAPGGAAGGAGATAGATALVSSKELVALQSKMQALSEKQIQVLTEHLGLDADASLSQLAKLSTESASLHKALDSVSAEHGDAYIKGIQGIFSAAKARTFKSFWNWSRQNLEELFADILQDRVSDDSTLLARIIQVWNQLDDVGILEQQLDQLQRSGVAGSDRVTSLFDPLLRQAKSGALKTAPRFIDVSVPLRPSTRLDSRGNIVYQQVPRDGMETILDYVTSMTSDKESKASAGQASSKSLIGRLEDLAQILSRLDEDQTSDVSIGSRPALWACKKVNSTWSRDDDLTEIYFRGLAKLAERGSSYAGLDVLLTGVGQGSIAFEVMRRFLRGGARVIVTTSTFSPKKLRMYGDTYRHDGARGAQLIVLPFNQGSFKDTQALVDHVYTSMGIDIDVLVPFAAISENGRNIDGIDDKSELAHRIMLTNVIRLMGCIKSAKAQRGILHRPTQVILPLSFNHGVLGGDGLYGPSKIGLETLLNTFESEDWSRYLSVAGARIGMCRGTDLMASSDIVAESLERHFGFRTFSTGEMAFNLLGLVEPEFASVNQTQPILLDLTGRASSLASPGKAMRDAHQEWQRKSDIKKALLSENRHDFKTTSSTRVTEDHYRRVEIEPRSLHHFAYPELNSQQVCDQIAKGTCHLDLDQVIVISGFAEVGPWGSSRTRWEREVSETWSLEGLVEMAWLTGHIKHFNGRLADGRSYIGWVDTKTGEPVADAQMRARYARQVEQHAGIRLVEPELMHGFDPERKVIQQEIELTHDLGPLEISAGEAERFRLAHGDKAIVWQDEETKSWYLRLKKGASVFLPKASRFDRHVAAQMPTGWDPARYGIPSDIVSQTDETALYALVCIAEALVQSGIDDPYELYKHVHVSEVGTSLGSAMGGLRSLAKMFKDRRQDVEVQKDILQETFINTVAGWTNLLLLSSCGPIKPTVGACATALQSLDVAAETIRCGKAKIMIAGGYESISEESMTEFANMKATASSDEAFAAGLAPEELSKPMTSGRSGFVEAQGCGVQIVMSAATAIRIGAPINGIVAYTQTATDRQGRSIPAPGKGVLAATVPLQRAMSGWGLDGNDVGVISMHGTSTKANDKNESNVYHTMLGKLGRAEGRAVPAMAQKWLCGHGKGGAAAWAINGLMQSINDGIVAGNRNADDISEELRAYNRIVYPSRSIRYSRERLHAGLVTSFGFGQVGGIAMILHASHLFGRLDREAFELYKARRNKRQQITYRRMHSLFIKGDLVRIKEDAPYSPEDETAVLLDIDARAELSSEGSYRIVPSIYA
What is the function of this protein?
Fatty acid synthase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA) (PubMed:15932999, PubMed:17850255).  UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U. maydis (PubMed:15932999, PubMed:17850255).  UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group (PubMed:17850255).  In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid (PubMed:17850255).  UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1 (PubMed:17850255).  Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2 (PubMed:17850255).  Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable).  The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable).  The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable).  The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable).  The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion (PubMed:17850255).
What are the official names of this protein?
Fatty acid synthase 2, Ustilagic acid biosynthesis cluster protein fas2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.