PharMolix/UniProtQA huggingface dataset:
Protein: PFKA_WHEAT
Sequence: FSRKTWRIFLQVYVIGGDGTMRGAVVIFEEFKRCRLRISITGIPKNLDNDIEIIDKAFGFQTAVESAQ
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX8A_BOVIN
Sequence: MSVLTPLLLRGLTGPARRLPVPRAQIHSKPPREQLGTMDIAIGLTSCFLCFLLPSGWVLSHMENYKKRE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 8A, mitochondrial, Cytochrome c oxidase polypeptide VIII-liver, Cytochrome c oxidase subunit 8-2, IX.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIII family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PHO34_ARATH
Sequence: MNPDSDYPHLPNIKIHHPSSPRHSHHHSSSTPSAATPTPTAGARRKIGVAVDLSEESAFAVRWAVDHYIRPGDAVVILHVSPTSVLFGADWGPLPLQTPPPPSAATDPGAQPKPSQEDFDAFTSSKVADLAKPLKEAGFPHKIHIVKDHDMRERLCLETERLNLSAVIMGSRGFGAEKRGSDGKLGSVSDYCVHHCVCPVVVVRYPDDRDGPAPPGNVGATREAIVTVKSRRDDDDDDDEDHEAKIAAAASDHHEHIKDE
What are the official names of this protein?
Universal stress protein PHOS34, Phosphorylated protein of 34 kDa, AtPHOS34.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSBH_ORYSJ
Sequence: MATQTVEDSSRPGPRQTRVGNLLKPLNSEYGKVAPGWGTTPFMGVAMALFAVFLSIILEIYNSSVLLDGILMN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RUVC_BARQU
Sequence: MAETIRIIGIDPGLRRTGWGVIDFSGNRLQFVAAGTLSSDARCDLASRLCQLYKGLSDILHQFMPHEAAVEHVFVNKDATATLKLGQARAIALLAPAQANLPVFEYAPNKVKKSVIGVGHGAKEQIHMMVKVLLPRAEFDSSDAADALALALCHSTHRTSASHYARITA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RS15_RHOCS
Sequence: MSITPERKQALIEEYKTKDGDTGSPEVQVAILTERIVNLTEHLKTHAKDFHSRRGLLVMVGQRRGLLDYLKRKNQGRYDTLIQRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: GET4_CHICK
Sequence: MAAAIMAAEQEAAKGGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQGKYVEARELMYSGALLFFSHNQQNSAADLSMLVLESLEKSDAKVTDDLLENLAKLFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPKLHQLLAITLWKDGEGCANMLVEYSSSRGYRSEVDMFVAQAVLQFLCLKNKTSASVVFTTYTQKHPSIEKGPPFVQPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLKRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLNSLMGTGEDDDTEDGQEDSSPIELD
What is the function of this protein?
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.  The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.  Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum.  Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome.  Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum.  The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome.  It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
What are the official names of this protein?
Golgi to ER traffic protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the GET4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ARLY_LACLM
Sequence: MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTIADGLIKVEEKLMKGQIEFKIENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHLYLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQHAQPISFAQHLMAYYQMFTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFLSNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRVYGNLISLLTVMKGLPLTYNKDLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKATEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKGIYLQEVSLKDYQALSQLIEEDVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_BURVG
Sequence: MSDILDRIIAVKRDEVAAAMRSTPLEALKLEASARDLRDFVGALRAKQAAGQPAVIAEVKKASPSKGVLREHFVPADIARSYATHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRKDFIVDAYQILEARAMGADAILLIAAALDTPLMQELEAYAHSLGLAVLVEVHDRNEMEQALTLKTPLVGINNRNLRTFETTIQTTLDMLDMVPADRMVVTESGILSRADVDTMRAANVNAFLVGEAFMRADEPGAALARMFF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: NUOB_DESVM
Sequence: MAAQDCPVRPPVIAPATGGVDAPIVNVAPVQKILDVCRAMSLWPMTFGLACCAIEMMAVGMARFDISRFGAEVFRPSPRQSDLMIVAGTVTRKMAPALVRLYEQMPAPRYVMALGNCAISGGPFNFEGQYAIVEGVDNLVPVDVYVPGCPPRPEALLEGLFQIQHKITGRRWWPVPAEISGSMGGGA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FRSA_VIBVU
Sequence: MSEEVSKNLSETLFVKHKQAKETSALTQYMPTSQSLLDEIKEKNGFSWYRNLRRLQWVWQGVDPIEQEQVLARIASSKHSRTDEQWLDTVMGYHSGNWAYEWTRLGMEHQKRAGEMTNEAASEALFSASLCYSIAGYPHLKSDNLAIQAQVLANSAYLEAAKKSKYIIKQLEIPFEKGKITAHLHLTNTDKPHPVVIVSAGLDSLQTDMWRLFRDHLAKHDIAMLTVDMPSVGYSSKYPLTEDYSRLHQAVLNELFSIPYVDHHRVGLIGFRFGGNAMVRLSFLEQEKIKACVILGAPIHDIFASPQKLQQMPKMYLDVLASRLGKSVVDIYSLSGQMAAWSLKVQGFLSSRKTKVPILAMSLEGDPVSPYSDNQMVAFFSTYGKAKKISSKTITQGYEQSLDLAIKWLEDELLR
What is the function of this protein?
Catalyzes the hydrolysis of esters (PubMed:30951551).  In vitro, prefers short chain alkanoate ester as substrate.  Displays highest activity towards p-nitrophenyl acetate (pNPA).  Has weaker activity towards p-nitrophenyl butyrate (pNPB) (PubMed:30951551).
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: NUSB_LIMRJ
Sequence: MSLNRHMIREEAFQVLFALQSDSEADIQTVYEAIPHHDEKQIPPYLLTLVNGVREHQDQLDEQINDLLASGWTINRLAKPDLVILRLALFEIQYAENVPTVVAINEALELTKTFSSDKSRKFINGALGKFEKQVNENN
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: ATPE_HELPS
Sequence: MALLKISVVVPEGEVYTGEVKSVVLPGVEGEFGVLYGHSNMITLLQAGVIEIETENQKEHIAINWGYAEVTKERVDILADGAVFIKKGSDDRDDAISRAKKLLEDASSDRLAVSSVLAKIESL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRG_STRPQ
Sequence: MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRDVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFVFSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: FOLD_CHRVO
Sequence: MSAQLIDGKAVAEKLLEKVSAGVGERLAQGKRAPALAVILVGDNPASAVYVGSKKKACEKAGIRSVAYDLPASTSQQQLLEIIDGLNADDAVDGILVQLPLPEQIDPQAVIERIDPKKDVDGFHPYNVGRLAIKMPLMRPCTPRGVMTLLEEYGIDPKGKKAVIVGASNIVGRPQALEMLLARATVTVCHSATRNLAEEVAAADILVVGVGIPNFVKGEWVKPGAVVIDVGINRLDTGKLCGDVEFDAARERAGFITPVPGGVGPMTVATLLQNTLDSANLNA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GATA_BURM1
Sequence: MHAKSLTELRAALAAKECSAVELAQHYLKRIDAARDLNAFVHVEPELTLAQAKAADAELARGAGGPLTGLPIAHKDVFVTRGWRSTAGSKMLANYESPFDATVVARLQAAGMVTLGKTNMDEFAMGSSNENSAFGAVKNPWDTNAVPGGSSGGSSAAVAARLAPAATGTDTGGSIRQPASFAGVTGIKPTYGRVSRYGMIAFASSLDQGGPMAQSASDCALLLNAMAGFDERDSTSLERDDEDFARHLGQPWAPGNDAGKPLAGLRIGLPNEYFGDGLADDVRAAIDAALKQYEALGATLVPVSLPKTELSIPVYYVIAPAEASSNLSRFDGVRFGHRAAQYGDLLDMYKKSRAEGFGPEVKRRILVGTYVLSHGYYDAYYLQAQKIRRIIANDFQEAFKSCDVIMGPASPTVAWDLGAKGDDPVQMYLADIYTLSVSLAGLPGMSVPCGFGAGANAKRPVGLQIIGNYFNEARMLQVADAFQRATDWHKQVPQVPAGV
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: SUS1_DEBHA
Sequence: MTQQQDELDQIKSQIQEHLISSGNYDIINKQLKLQLYESGWFDKVTQLANRELQENSAHDTAVSFDQLFSFVKPKAEEMVPSNIKEDVLERLKDYLDDVIQ
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels.  The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.  May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
What are the official names of this protein?
Transcription and mRNA export factor SUS1.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm, P-body.
Protein: PSBH_SOLBU
Sequence: MATQTVENSSRSGPRRTAVGDLLKPLNSEYGKVAPGWGTTPLMGVAMALFAVFLSIILEIYNSSVLLDGISMN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RGTD_RHIL3
Sequence: MSPRSGLLIVLGFTLWRVVMLNFDATDFFVDEAQYWFWSQNLDLGYYSKPPMIAWVIRAMTELSGSNAIYWIRLLGPLIHMAAALVLMKTAKRFVGPEIEGWTGATYITLPGVALSSVFFSTDVILLFFIAIALLAYFGLTQRRSVGLALVMGLGVGLAFLTKYAVLFVVPGGAIALLLIPAARIAVRDVIIAVAVAAVVALPNLWWNLQHDNTTVRHTQDIAHWSELGINLRRGLEFFAAQFGVVGPIIFFAMLWAVYRMIRGRSDDREKMLVWLSMPVVLLITLQATVAKAYANWAVTAYVAGTILAVWLLYLKWPKGLRLSLTINGIASLLFPLATIFPHQLLLPNGDALMKRYLGRAEVSREAAALATQAGTDIIVTDNRDMVADLFYTLRDASYRIYARAPAGLPESYYEQEFALPADITGKVLFLTDGAFTCATETPEVLKNWQPTEGNYKGKTLSIYKVSATCLAP
What is the function of this protein?
Involved in the modification of the lipopolysaccharide (LPS) lipid A moiety.  Catalyzes the transfer of a galacturonic acid (GalA) residue to the 4'-position of 4'-dephosphorylated lipid A, using dodecaprenyl phosphate-GalA as the donor substrate.  Acts before the other GalA transferases RgtA, RgtB and RgtC.
What are the official names of this protein?
Lipid A galacturonosyltransferase RgtD, Lipid A GalA transferase RgtD, Galacturonic acid transferase RgtD, GalAT RgtD.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPH_CLOBB
Sequence: MSYNLTDPYEIARFIKESKKSTPVKVYVNGDLSKALMDDIEWYGANGFYILIGESDLIAKIILDNKHLIKHFRLENDRRNSAIPMLDLLEVDARIEPGAIIRDKVTIGKNAVVMMGAVINIGAEIGDGTMVDMNAVIGARGKLGKNVHLGAGAVVAGVLEPPSKEPCTIGDNVLIGANSVILEGVRIGSGSVVAAGSVVAEDVPEGVVVAGSPAKIIKLVDDKTKGKTQLLDDLRK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: IF2P_METMA
Sequence: MTDKKNLRTPIVCVMGHVDHGKTTLLDKIRGTAIVSGEAGAITQHIGATEVPIDVIIDKLGDPRLRDRFMVPGLLFIDTPGHHAFTTLRSRGGALADLAIVVVDINEGFKPQTYESLQILKRFKTPFVVVANKIDRIGGWVSQKDMPFAATFKKQSSDVQARLETKLYEVIGELYNQGFAAERYDRVTNFQKTLGVVPVSAFTGEGIPDVLMVLLGLAQKFLEANLQYSAKGPGVGTVLEVKEEKGLGATLDIILYDGTLKKGDTVVIGSLGEPIRTKVRALLKPRELSEIRYESKFQQVSKVTAAAGVKISAPGLEGALAGSPIRVATEDNLEEIASQVKSEIDEVRIDTGSVGIMIKADTLGSLEALVHEFQKDEVPIRKAEVGDISHRDAVEASTVEDPLYSVIIGFNVKVHPDARDFLQESSVKVFTSDVIYRLVEDYQKYVKEQQEKAEKKIFETIIRPGKFKILPGCVFRQSKPAVVGVRVLGGVVRTNTDVMLENGNVVGKIKGLQSEGENIPSAKVGKEVAMAIEGATVGRQIKEEDVLYVNVPERHAKVLEHEIYESLSTDEKETLDIFLTLKRKDNPFWAK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: SPT13_MOUSE
Sequence: MHPASVTTTSQDPCAPSGSCRGGRRRRPISVIGGVSFYGNTQVEDVENLLVQPAARPPVPAHQVPPYKAVSARLRPFTFSQSTPIGLDRVGRRRQMKTSNVSSDGGAESSALVDDNGSEEDFSYEELCQANPRYLQPGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRNEDKEAWFPASFVRLRVNQEELPENCSSSHGEEQDEDTSKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLEHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHFFEACRLLQQMIDIALDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCKKDLLRRDMLYYKGRMDMDEVELVDVEDGRDKDWSLSLRNAFKLVSKATDEVHLFCARKQEDKARWLQAYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGKSKGYNSCPVAPPHQSLPPLHQRHITVPTSIPQQQVFALAEPKRKPSIFWHTFHKLTPFRK
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases.  Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism.  Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity).  Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells.  Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
What are the official names of this protein?
Spermatogenesis-associated protein 13, APC-stimulated guanine nucleotide exchange factor 2, Asef2.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Protein: STKLI_ARATH
Sequence: MVGTKRVADSIDTNSDDTLTRNREVEVEAMLSRRKQLRTTTTRTTTTRTTPLSLSSSASKMNWSKNDELVILGGIVDYENETKLSYRSDWDALYRYIKDCVEAKFSKIQLINKVKNMKRKFTYNQGRSNHGEQLSFTNTDDDEIFKLSLIIWDKNESEYVSNENIDQAKDVPSGEPETNDVPCEEQDDRDVPCEEQERANIEIDNGVREKLDQAKDVPCVEQESEDVPCVEQERVSIEIDNGEKEKLDQTMDCEEQENTDVLCEEKGDKDVPCEEQENKDVPCEEQERVSIEIDNGEEEMSSEEDGVDEVGVMEDTLDSGISFQGLGKNGVKDKSEEDDVVELGVLQEIFKEDTFFQSLGRYQQKLLLQNLENVGVERRKELINEWKALFVDEQRLCVKKLTFAAKLANLGVSP
What is the function of this protein?
Probable transcription factor.  Involved in stress responses (PubMed:21875893).  Plays a repressive role in cell expansion by counteracting the positive role of CPR5 in this process, but does not regulate cell proliferation or endoreduplication (PubMed:21875893).
What are the official names of this protein?
GLABROUS1 enhancer-binding protein-like 3, Protein GPL3, Storekeeper-like protein At2g36340.
What is the protein family that this protein belongs to?
Belongs to the GeBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3345_CHRVO
Sequence: MDAKFLEILVCPLCKGPLVFDKSKDELICKGDRLAFPIKDGIPMMLESEARELAPEEEVK
What are the official names of this protein?
UPF0434 protein CV_3345.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: CKX2_ORYSJ
Sequence: MKQEQVRMAVLLMLNCFVKATAPPPWPPSASSASFLDDLGDLGIAPLIRADEAGTARASADFGNLSVAGVGAPRLAAAAAVLYPSRPADIAALLRASCARPAPFAVSARGCGHSVHGQASAPDGVVVDMASLGRLQGGGARRLAVSVEGRYVDAGGEQLWVDVLRASMAHGLTPVSWTDYLHLTVGGTLSNAGISGQAFRHGPQISNVLELDVITGVGEMVTCSKEKAPDLFDAVLGGLGQFGVITRARIPLAPAPARARWVRFVYTTAAAMTADQERLIAVDRAGGAGAVGGLMDYVEGSVHLNQGLVETWRTQPQPPSPSSSSSSSFFSDADEARVAALAKEAGGVLYFLEGAIYFGGAAGPSAADVDKRMDVLRRELRHERGFVFAQDVAYAGFLDRVHDGELKLRAAGLWDVPHPWLNLFLPRSGVLAFADGVFHGILSRTPAMGPVLIYPMNRNKWDSNMSAVITDDDGDEVFYTVGILRSAAAAGDVGRLEEQNDEILGFCEVAGIAYKQYLPYYGSQAEWQKRHFGANLWPRFVQRKSKYDPKAILSRGQGIFTSPLA
What is the function of this protein?
Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group (PubMed:15976269).  Is a major QTL involved in grain yield (PubMed:15976269).  Modulates the number of reproductive organs by regulating the cytokinin accumulation in inflorescence meristems (PubMed:15976269, PubMed:28337744).  Acts as negative regulator of panicle branching (PubMed:15976269, PubMed:28337744).
What are the official names of this protein?
Cytokinin dehydrogenase 2, Cytokinin oxidase 2, OsCKX2, QTL grain number 1a, Gn1a.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.