PharMolix/UniProtQA huggingface dataset:
Protein: RNH2A_SCHPO
Sequence: MKDDHDAWEPEELVSDNNSSENELQEDQNSSITFLPPSVNKSNPAKSNYYHSTVTDDISKSQPYRLGVDEAGRGPVLGPMVYAVAYCPVDFDLTNYGFADSKTLASLKREELLKLICNKSNELGKNVGWSTMSISARELAAGMLRYRNKYNLNLQAHDTTIDLIKKVYESGINVTEIYVDTVGPPISYQEKLQAHFPQAKVTVTKKADSLFPIVSLASICAKVTRDIQLECARESIRTENWGSGYSSDARTTEWLKVNVDKIFGWKGDIVRYSWKTAKDLLELPSKSQSSIEIDWHEDDDTPTLNFTQKKKPNPASRSWFGSEFYF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.  Participates in DNA replication.
What are the official names of this protein?
Ribonuclease H2 subunit A, RNase H2 subunit A, Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. Eukaryotic subfamily.
Protein: QUEC_SULDN
Sequence: MNLKNKKAICIMSGGMDSTLGAYMVKEMGYEIVALHFNYAQRTEAKELFCFKKICEALNVSNSYVLDLDFFSKIGASALTDKSIDIPINGLEEGVPITYVPFRNGIFLSIAAALAEKEEAVLIAIGVVQEDSSGYPDCKDSFITSMEQSINLGTKDETKIKIYMPLVHLSKSQIVEHALRLNVPLELTWSCYKDEEAACGVCDSCRLRLNGFRLANAKDPIEYM
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NAV3_HUMAN
Sequence: MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQSSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQSSTATSPTPSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVNARTALRPPQPPSSGPSDGGKDDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKNKVCTEKPVKEEKDQVTEMAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTVKQTISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREAGQASPSGSCTMTVAQSSGQSTGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLNRIPDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGKWKTVSSGLPEDPEKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAKASEKGKAPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYSSTQSCDSESTSHHEDILDSSLESTL
What is the function of this protein?
Plays a role in cell migration (PubMed:21471154).  May be involved in neuron regeneration.  May regulate IL2 production by T-cells.
What are the official names of this protein?
Neuron navigator 3, Pore membrane and/or filament-interacting-like protein 1, Steerin-3, Unc-53 homolog 3, unc53H3.
What is the protein family that this protein belongs to?
Belongs to the Nav/unc-53 family.
What are the subcellular locations of this protein?
Nucleus outer membrane.
Protein: RT25_YEAS7
Sequence: MKIQTNAVNVLQRTSAYLKSGLLKETPAWYNVVASIPPSTKFTREPRFKNPSNGHIIGKLVDVTEQPHANNKGLYKTRPNSSDKRVGVKRLYRPPKLTYVEDRLRSLFYKQHPWELSRPKILVENEIGDENYDWSHMLQIGRPLDGESVIQRTMYLIKTKQYGDMVEAYDHARYEFYALRMQEETEQQVALEEAEMFGSLFGVSAIEHGIQKEQEVLDVWEKKVVEETELMAARTSNPAGSWKDDTTLNTAQEEESTTSENLHF
What are the official names of this protein?
37S ribosomal protein S25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RPOZ_SYNS3
Sequence: MISAGVDSKDLAKRGESLIRQSTNRYLTTVKIAFRAKQRRFDDFDGLLEESSVKPVHRAIVELSDEQDQPDLLPG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RNS13_HUMAN
Sequence: MAPAVTRLLFLQLVLGPTLVMDIKMQIGSRNFYTLSIDYPRVNYPKGFRGYCNGLMSYMRGKMQNSDCPKIHYVIHAPWKAIQKFCKYSDSFCENYNEYCTLTQDSLPITVCSLSHQQPPTSCYYNSTLTNQKLYLLCSRKYEADPIGIAGLYSGI
What is the function of this protein?
Does not exhibit any ribonuclease activity.
What are the official names of this protein?
Probable inactive ribonuclease-like protein 13.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: IDH4_ARATH
Sequence: MPRPVTVIDSNVTNAVHQVMDAMQAPVYFETYIIKGKNMNHLTWEVVDSIRKNKVCLNGRVNNSLCGGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEIASRETRAIRRHSNSKSLWAIIANIASGVAGGSFGDDYAIFEQVGSVGNHKNPVALLFSSVMMLRHLLLPLFADRLKTAVTRVISEGKCGNSNTTTQEVVDSVIANLD
What is the function of this protein?
Performs an essential role in the oxidative function of the citric acid cycle.
What are the official names of this protein?
Putative isocitrate dehydrogenase [NAD] subunit-like 4, IDH-IV, Isocitric dehydrogenase-like protein 4, NAD(+)-specific ICDH 4.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: NADA_CALBD
Sequence: MNIEVLKNEIYKLKEEKNALIVAHNYQIDEVQEIADFVGDSFYLSKVCAERPEKVIVFCGVHFMAESAKILSPHKKVLLPEIDAGCPLADMVTAEDVENLKKKYPDYSIVCYINSPASVKAKSDVICTSSNAVKIVREFPNDKIIFLPDKNLGSFVKKQVPEKDIILWEGFCITHYKIKKEDVEKAKSLHPNALVLVHPECRPEVVELADFVGSTKQIIDFANTSKEKEFIIGTEMGVLYSLKKLNPDKKFYILHPGMICPNMKKNTLQSVRDALLYERYQIEVEEEIMEGAKKALSKMLEMG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_GEOMG
Sequence: MKRLAVSILCLALAGCAIEKAEVRTPSFDEQLPAPQPSYASGSIWQAASAGIAEDHKARRKGDIITVVIVENASASKQATTDTDRKASISASIPYLMGLEKQKLILGKLTGADLGNLLGASTDSTFGGSGATTRKENLVATMSAKIIDVLPNGNFLIEGRRNVKVNNEDQIIILQGTVRPRDVSPDNTVNSSLIADARITYTGEGVISDRQRPGWLMNFLDYIWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: ALLB3_BETPN
Sequence: MPCSTEAMEKAGHGHASTPRKRSLSNSSFRLRSESLNTLRLRRIFDLFDKNSDGIITVDELSRALNLLGLETDLSELESTVKSFTREGNIGLQFEDFISLHQSLNDSYFAYGGEDEDDNEEDMRKSILSQEEADSFGGFKVFDEDGDGYISARELQMVLGKLGFSEGSEIDRVEKMIVSVDSNRDGRVDFFEFKDMMRSVLVRSS
What is the function of this protein?
Could be involved in calcium metabolism in pollen.  Binds 3 calcium ions.
What are the official names of this protein?
Calcium-binding allergen Bet v 3, Allergen Bet v III.
Protein: ATPD_DECAR
Sequence: MAESVTIARPYAEALFRTAKESGNLAKWSEQVSLLGQVAANPDVSSAIGDPNVAAPQLVDLFRSACGTAVDAELSNFIQLLSNNDRLGLLPEIAGLYETYKRAEEGTKQADIVSAFPIDDNQVKALIPQLEAVFKTKLEAAVSVDPTLIGGIKVIVGDQMLDASVRGKLDAMATALNN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CRCB_RALPJ
Sequence: MSGMGFLAVGVGAALGAWLRWALAILLNAVNPALPYGTLAANLVGGYLIGVAVGFFDTHAGLPPEWRLLVITGFLGGLTTFSTFSGEVVANILAGDHVIGVLHIVAHLGGSLFLTMLGFWTVRTFS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPDA_SALPC
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_CAMJ8
Sequence: MSKKALCIISGGMDSTLCAYLAKKEGYEIIALHFDYEQRTQEKERECFKQICKALKVEKSYILDVSFIKDIGGNALTDKSIDIPKNELCISDTPPITYVPFRNGIFLSIAGSLAEKENCESIFIGVVEEDGSGYPDCTDEFIQKAQEFINEGTSKNFKVYIKTPLVRLNKAKIVELALKENVPLELTWSCYESEDEACGECDSCLLRLRGFEKVGFKDKIKYKS
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: STM1B_XENLA
Sequence: KREHEKEVLQKAIEENNNFSKMAEEKLTTKMEAIKENREAQMAAKLERLREKDKKLEEIRKGKECKEPSED
What is the function of this protein?
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules.  It prevents assembly and promotes disassembly of microtubules (By similarity).
What are the official names of this protein?
Stathmin-1-B, Stathmin clone XO20.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SIR4_MOUSE
Sequence: MSGLTFRPTKGRWITHLSRPRSCGPSGLFVPPSPPLDPEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLLVVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRCGELLPLIDPRRQHSDVQRLEMNFPLSSAAQDP
What is the function of this protein?
Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:19220062).  Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications.  Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879).  Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity.  Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573).  In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782).  Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782).  Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (PubMed:23746352).  Does not seem to deacetylate PC (PubMed:23438705).  Controls fatty acid oxidation by inhibiting PPARA transcriptional activation.  Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310, PubMed:20685656).  Down-regulates insulin secretion (By similarity).
What are the official names of this protein?
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, NAD-dependent ADP-ribosyltransferase sirtuin-4, NAD-dependent protein biotinylase sirtuin-4, NAD-dependent protein deacetylase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: O51J1_HUMAN
Sequence: MKISNNSLGFLPTTFILVGIPGLESEHLWISVPFSLIYIIIFLGNGIILHVIRTDIALHQPMYLFLAMLALAEVRVSASTLPTVLGIFLFGNTEISLEACLFPDVLHPFFIHDGASCAAGHVFGPLYSHLQPTELHSYPDTAQGLWHRSYYRTEKHYAHGSVAHSLMASALLWPQCPLTFLLSAPQSYLSCGNISVNNIYGIFIVTSTFGLDSLLIVISYGLILHTVLGIATGEGRKKALNTCGSHVCAVLAYYVPMIGLSIVHRLGHRVSPLLQAMMANAYLFFPPVVNPIVYSIKTKEIHGAIVRMLLEKRRRV
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 51J1, Odorant receptor HOR5'beta8, Olfactory receptor 51J2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS9_PSEPK
Sequence: MSATQNYGTGRRKTATARVFLRPGTGNISINNRSLDVFFGRETARMVVRQPLELTESVEKFDIYVTVSGGGVSGQAGAIRHGITRALMEYDETLRGALRRAGYVTRDAREVERKKVGLRKARKRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: FABA_PSESM
Sequence: MTKQHAFTREDLLRCSRGELFGPGNAQLPAPNMLMVDRITHISEEGGKFGKGELVAELDINPDLWFFACHFEGDPVMPGCLGLDAMWQLVGFYLGWQGNPGRGRALGSGEVKFFGQVLPTAKKVTYNIQIKRTMRGKLVLAIAEGTVSVDGREIYSAEGLRVGLFTSTENF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD2_MYXXD
Sequence: MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEEVGFRSWELHPDEGITQAALLEVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDVDGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGKRAVVVGRSNIVGKPMALMLLQKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLVGDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GSCB_XENLA
Sequence: MPSGMFSIDNILAARPRCKESLLLPQNGPLLFSSLGESLYGPADYSGFYNRTVAPTSALQGVNGSRLGYNNYYYGQLHLQTPVGPSCCGAVQALGTQQCSCVPSATAYDGAGSVLIPPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARRVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAQKWNKSSKNSAEKRDEQAKSDLDSDS
What is the function of this protein?
Plays a central role in executing Spemann's organizer phenomenon (the dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another embryo).
What are the official names of this protein?
Homeobox protein goosecoid isoform B.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HOME1_MOUSE
Sequence: MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
What is the function of this protein?
Postsynaptic density scaffolding protein.  Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.  By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.  May also couple GRM1 to PI3 kinase through its interaction with AGAP2.  Isoform 1 regulates the trafficking and surface expression of GRM5.  Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2.  Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites.  Isoform 3 regulates the trafficking and surface expression of GRM5.  Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function.  Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity).  Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).  Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway.  Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
What are the official names of this protein?
Homer protein homolog 1, Homer-1, VASP/Ena-related gene up-regulated during seizure and LTP 1, Vesl-1.
What is the protein family that this protein belongs to?
Belongs to the Homer family.
What are the subcellular locations of this protein?
Cytoplasm. Postsynaptic density. Synapse. Cell projection, dendritic spine. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. The N-terminal of isoform 2 may facilitate trafficking of the complex with GRM5 from the endoplasmic reticulum (ER) to the plasma membrane (PM).
Protein: DTD_PARXL
Sequence: MIALIQRVRRAEVRVADRVTGAIEAGLLALVCAERGDTEAAADRLLAKVLGYRVFSDAAGKMNLSVQNLDGAGRAGGLLLVSQFTLAADTNSGLRPSFTPAAPPDEGKRLFDYFVAAARAKHPVVETGEFGADMQVSLVNDGPVTFWLQTHA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_PSEPG
Sequence: MHALQAKILDPRLGSEFPLPTYATPGSAGLDLRALLKEDTVLEPGQTLLIPTGLSIYIGDPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGELMVSCWNRSNTPFTIAVGERIAQLVLVPVVQAHFDIVEAFDESQRGAGGFGHSGSH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RNP1_PYRAB
Sequence: MRRNGKERKDRTSGGSQRPYQEIVGRTWIFRGSHRGRVTKRNIIWHELIGLKVRVVNSMHPGFVGIEGYVVDETRNMLVIVGDKVWKVPKDVCIFEFETEDGAKIKIPGERLVGRPEMRLKKRWRKW
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 1, RNase P component 1, Rpp29.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUP43_MOUSE
Sequence: MEEIYAKFVSQKISKTRWRPVPSGSLQTTETFATGSWDNEENCVSLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWPAAHYHTGPSSPSYSSAPCTGIVCDNPEIVTVGEDGRINLFRVDHKEAVRTIDNADSSTLHAVTFLRTPEIVTVNSIGQLKIWDFRQQGSEPCQILSLTGDRVPLHCVDRHPDQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHWDASTDAPEKSSLFHQGGRSSTFLSHSLSNQAGVHQSLVSSWLSTDPAKDRIEITSLLPSRTLSVNSLDVLGPCLVCGTDAEAIYVTRQLFS
What is the function of this protein?
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC).  The Nup107-160 subcomplex is required for the assembly of a functional NPC.  The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity).
What are the official names of this protein?
Nucleoporin Nup43, Nup107-160 subcomplex subunit Nup43.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Protein: RS7_DESPS
Sequence: MSRRKTIEKRPVTPDPRFNSVLVAKFTNGLMERGKKSLAQRIFYDAMDLVADRMKDEEPLTVFEEAMEKVRPRVEVKSRRVGGATYQVPMEIRQARRNALAIRWIISYAKSRSGKCMSEKLASEVMDAFNNRGAAVKKRDDTHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.