PharMolix/UniProtQA huggingface dataset:
Protein: SMC2_HUMAN
Sequence: MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
What is the function of this protein?
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
What are the official names of this protein?
Structural maintenance of chromosomes protein 2, SMC protein 2, SMC-2, Chromosome-associated protein E, hCAP-E, XCAP-E homolog.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein: RNH_YERPN
Sequence: MTKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALTSPCEVTLSTDSQYVRQGITQWIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEWVKGHAGHPENERCDELARQGANSPTLDDTGYNPD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_BACC3
Sequence: MAAKWEKLEGNVGVLTIEVDAKEVNNSIDAAFKKVVKTINVPGFRKGKMPRPLFEQRFGIESLYQDALDIILPKAYGEAIDEAGIFPVAHPEIDIEKFEKNANLIFTAKVTVKPEVKLGEYKGLAVEKVETTVTDEDVENELKSLQERQAELVVKEEGTVENGDTAVIDFEGFVDGEAFEGGKGENYSLAIGSGTFIPGFEEQVIGLKSGESKDVEVSFPEEYHAAELAGKPATFKVTVHEIKTKELPELNDEFAKEADEAVATLDELKAKLRTNLEEGKKHEAEHKVRDEVVELAAANAEIDIPEAMIDTELDRMVREFEQRLSQQGMNLELYYQFTGTDADKLKEQMKEDAQKRVRINLVLEAIIEAENIEVTEEEVTAEVEKMAEMYGMPVDAIKQALGSVDALAEDLKVRKAVDFLVENAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RS12_STRPM
Sequence: MPTINQLVRKPRKSKIEKSDSPALNIGYNSHKKVQTKMAAPQKRGVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVADRKQGRSKYGAKRPKG
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: EFPL_PROMH
Sequence: MAKANEIKRGMAISYNNKLLLVKDIDIQAPSARGASTLYKMRFTDIRTGQKVEERFKGDDILDTINLTRRAVSFSYIDGDEYVFMDNEDYTPYTFKKDQIEEELLFIPEEGLAGMQVLTMDGQVLALELPQTVDMEIIETVPGIKGASASARTKPATLPTGLVIQVPEYLSTGDKIRIHIAERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: UVRB_PSEU2
Sequence: MSEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTLVLAPNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHIDRGDKLDQRALLRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRFTFYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELGYCNGIENYSRYLSGRPSGAPPPTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEAEHAGRIVEQVVRPTGLVDPQIEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRAARNLNGRAILYADRITGSMERAIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEEKMYQLARDLEFEAAAQMRDEIGKLRERLLAV
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEK2_ORYSI
Sequence: MDQYEVLEQIGKGAFGSALLVRHKLEKKKYVLKKIRLARQTDRTRRSAHQEMQLIATVRNPFIVEYKDSWVEKGCYVCIVIGYCEGGDMAEAIKRANGTYFSEEKLCKWLVQLLMALDYLHANHILHRDVKCSNIFIARDQSIRLGDFGLAKILTSDDLASSVVGTPSYMCPELLADIPYGTKSDIWSLGCCIYEMTALRPAFKAFDMQALINKITKSIVSPLPTKYSGAFRGLIKSMLRKSPEHRPSAAQLLKHPQLQPYVLQVQLKSSPTRNILPIHQSLTDKVKKMTFPSDVVDSARRRMARRNSLGNERTVTFSKPSPERNSVSSTRSIKEYTTTQSVEGLSVDSSEAGDEVTSKAIITKTSSILRTPKSLPAKTYTARNQLEPPKTSYNRTYRSELPSKTTPNKIARPARRASLPLSTYETPTKRSISILEQLDSPDVSVNAPRIDRIAEFPLASSEDPLLPIHNKLSPGHGSCSTPPFINRSITKDKCTIQVLRTDGDNGSDSSGRNATAASSRGSNDSRQQRFDTSSFQQRAEALEGLLEFSAQLLQQERYEELGILLKPFGPEKASPRETAIWLTKSFKETAS
What is the function of this protein?
May be involved in plant development processes.
What are the official names of this protein?
Serine/threonine-protein kinase Nek2, OsNek2, NimA-related protein kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: TYK2_HUMAN
Sequence: MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
What is the function of this protein?
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:8232552, PubMed:7813427, PubMed:7657660, PubMed:10995743, PubMed:10542297).  Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297).  Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186).  The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:7813427, PubMed:10542297, PubMed:7526154, PubMed:25762719).  In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660).  In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:7657660, PubMed:10542297, PubMed:25762719).  Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
What are the official names of this protein?
Non-receptor tyrosine-protein kinase TYK2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Protein: PAX_I83A4
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEACFMYSDFHFIDERGESTIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPREAKRQLKKDLKSQEPCVGLPTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: GLMU_STAHJ
Sequence: MQRNAVILAAGKGTRMKSNKYKVLHKVAGKSMVEHVLTNVKNAGVNQIVTIVGHGAEDVKETLGNQSLYSYQEEQLGTAHAVKMANEHLKEVEGTTLVVCGDTPLITAHTLQKLIEHHESTHAQATVLSATAQIPFGYGRIVRDEQRRLQRIVEEKDASEAQKALTEISSGIFAFDNRVLFSKLEEVKNDNAQGEYYLPDVISLILAENGVAEVYHTDDFNEIMGVNDRVMLSNAEKALQQRINIEHMRNGVTIIDPTTTFIGPDVKIGMDTIIEPGVRINGETVIGEEAVIGQYSEINNSHIGSQVDIKQSVINDSIVGDKTKVGPFAQLRPGSNLGSDVKVGNFVEVKKADLKDGAKVSHLSYIGDAEIGERTNIGCGSITVNYDGVNKFKTVVGKDAFIGCNTNLVAPVTVGDGVLIAAGSTITDNVPNESLALARARQITKEGYLKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_HISS2
Sequence: MTQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIDRKGEILTQISNFWFKKLAHIMPNHFTGETVYDVLPQAEADLVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYKATGTICGLKLPEGLVEASKLPEPIFTPSSKAKVGDHDINISYEECEQLIGVELAKQVREKAISLYKEAAEYALTKGIIICDTKFEFGLDENGVLTLMDEVLTPDSSRFWSVETYQEGTNPPSFDKQFVRDWLEKSGWNKQAPAPKVPADVIQKTVDKYKEVLDLLTK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CP51A_ASPFN
Sequence: MIFSRSMASFTLVSAYAAAGLLAIIVLNLLRQLLFRNKTDPPLVFHWIPFLGSTVTYGMDPYAFFFSCRQKYGDIFTFILLGRKITVYLGIQGNEFILNGKLKDVNAEEIYSPLTTPVFGSDIVYDCPNSKLMEQKKFIKFGLTQAALESHVPLIEKEVLDYLKTSPNFKGTSGRVEITDAMAEITIFTAGRALQGEEVRKKLTAEFADLYHDLDRGFTPINFMLPWAPLPRNRKRDAAHARMREIYMDIINERRKNPDRETSDMIWNLMHCTYKNGQPLPDKEIAHMMITLLMAGQHSSSSISSWIMLRLASEPAVMEELYQEQITKLSPDGRTLPPLQYRDLDLLPLHQNLIKETLRLHLSIHSLMRKVKNPMPVPGTPYVVPADHVLLASPGVTALSDEYFPNASRWDPHRWENRVEKEDEEDIVDYGYGTVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVIVATMARHMKLFNVDGKKGVPATDYSSMFSGPSKPAIIGWERRFPEKS
What is the function of this protein?
As a target of azole drugs, plays a crucial role in azole susceptibility (PubMed:18775650, PubMed:29311090).
What are the official names of this protein?
Sterol 14-alpha demethylase, Cytochrome P450 monooxygenase 51A, Ergosterol biosynthesis protein cyp51A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: GLT10_CAEBR
Sequence: MGLSRYLSRRHHWVIQYCALLLFLYFIYSYVAVSNDAPRLNEEIPVFREFSEDLPQGSRKFPEQKPAAALGDEALDPFEKYRGHEKIKWEDEVAYEKDKAREGPGEWGKPVKLPDDKETEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKKMTYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKILRTKKREGLIRGRQLGAQEATGEILIFLDAHSECNYNWLPPLLDPIADDYRTVVCPFVDVIDCETYEIRPQDEGARGSFDWAFNYKRLPLTKKDRENPTKPFDSPVMAGGYFAISAKWFWELGGYDEGLDIWGGEQYELSFKVWQCHGKMVDAPCSRVAHIYRCKYAPFKNAGMGDFVSRNYKRVAEVWMDEYKETLYKHRPGIGNADAGDLKLMKGIREKLQCKSFDWFMKEIAFDQDKYYPAIEPKASAEGEIRHVASNLCIDTQFKEQNQRFGLRKCASEDKDGGGEQDLRLTRWHDIRPKGRKICFDVSTSVDKAPIILFDCHSMKGNQLFKYRMPQKQIYHPVSGQCLTADENGKGFLHMKKCDSSSKLQQWAWQTIDQELLDQRQANEHKELE
What is the function of this protein?
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
What are the official names of this protein?
Putative polypeptide N-acetylgalactosaminyltransferase 10, pp-GaNTase 10, Protein-UDP acetylgalactosaminyltransferase 10, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: DXS_SHEB5
Sequence: MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSVGHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSLFKKPTTKPGLPTFSQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAYDQLIHDVALQKLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGCATGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHEVLVTVEENAIMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: ASF1_YARLI
Sequence: MSIVSLLNIDVLNNPAPFGSPYEFQITFECLEPLKHDLEWKLTYVGSSTSFEHDQELDSLLVGPVPVGVNKFVFTADPPTVDLIPASELVSVTVIILSCSYNDREFVRVGYYVNNEYDSEELRLNPPPKVQVDHVVRNILAEKPRVTRFNIVWDNEGEQGEEFPPEQPDADLEDDEEEYGAGEEEEEVEEEVEGETEADAKEDIEAEGEAEAEGDGDGDGDGEDEDLEEASDEEMEVVDDEVGEESEGEDDKEDKDDKDDKKDDK
What is the function of this protein?
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
What are the official names of this protein?
Histone chaperone ASF1, Anti-silencing function protein 1.
What is the protein family that this protein belongs to?
Belongs to the ASF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCY_SHELP
Sequence: MSQRAPIVTIDGPSGAGKGTISQILASRLGWKLLDSGAIYRVLALAAIHHNVELDNEASLALLAAHLDVQFITANGNGIKVVLEGEDVSHAIRSQECSNAASKVAAFPRVREALLRRQRAFAEAPGLIADGRDMGTVVFPTSPAKLYLTASAEERAQRRYNQLQDKGFDVNIDRLLAEVVERDERDMNRPVAPLVPAEDALVIDTTGIGIDEVVELALSHIKEKLPDLVL
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O1X1_CONTE
Sequence: MKLTCVVIVAVLFLTVWTFATADDSGNGLEKLFSNAHHEMKNPEASKLNERCLDAGEVCDIFFPTCCGYCILLFCA
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like TxO1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_MYCLE
Sequence: MPVIEQVGAREILDSRGNPTVEVEVVLIDGTFARAAVPSGASTGEYEAVELRDGDGRYGGKGVKRAVDAVLDEIGPVVIGLNANDQRLIDQELLDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYIGGSNAHILPVPMMNILNGGAHADTAVDVQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKKGLSTGLGDEGGFAPEVAGTTAALDLVTLAIEAAGFKPGADVALALDAAATEFYTDGIGYHFEGMTHTADQMTEFYADLLGSYPLVSIEDPLSEDDWDGWAALTASIGEQVQIVGDDIFATNPERLEEGIGRGVANALLVKVNQIGTLTETLEAVALAHHSGYRTMISHRSGETEDTMIADLVVALGSGQIKTGAPARSERVAKYNQLLRIEEELGDAARYAGDLAFLRYVVETR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: UL16P_HCMVM
Sequence: MERRRGTVPLGWVFFVLCLSASSPCAVDLGSKSSNSTCRLNVTELASIHPGETWTLHGMCISICYYENVTEDEIIGVAFTWQHNESVVDLWLYQNDTVIRNFSDITTNILQDGLKMRTVPVTKLYTSRMVTNLTVGRYDCLRCENGTMKIIERLYVRLGSLYPRPPGSGLAKHPSVSADEELSATLARDIVLVSAITLFFFLLALRIPQRLCQRLRIRLPHRYQRLRTED
What is the function of this protein?
Plays a role in the escape of host immune response.  Blocks the interaction between the host KLRK1 receptor with their ligand ULBP1 and ULBP2.  ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines.  Therefore, the sequestration of diverse KLRK1 ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells (By similarity).
What are the official names of this protein?
Protein UL16.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL16 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: INT11_CHICK
Sequence: MPEIKVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGYNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTKAICPILLEDYRKITVDKKGETNFFTSQMIKDCMKKVVAVHLHQTVQVDEELEIKAYYAGHVLGAAMFQIKVGCESVVYTGDYNMTPDRHLGAAWIDKCRPDLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKAPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQILEVKMQVEYMSFSAHADAKGIMQLIRQAEPRNVLLVHGEAKKMEFLKQKIEQEFHVNCYMPANGETTTIFTNPSIPVDISLGLLKRETAIGLLPDAKKPKLMHGTLIMKDNSFRLVSPEQALKELGLAEHQLRFTCRVHIQDPRKEHETVLRVYNHLKGVLKDYSVQHLPDGSITVESILIQATAHSEDQGTKVLLVSWTYQDEELGSYLTSLLKKGLPQSTS
What is the function of this protein?
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  Mediates the snRNAs 3' cleavage.
What are the official names of this protein?
Integrator complex subunit 11, Int11, Cleavage and polyadenylation-specific factor 3-like protein, CPSF3-like protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SWP70_HUMAN
Sequence: MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
What is the function of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC.  It also mediates signaling of membrane ruffling.  Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
What are the official names of this protein?
Switch-associated protein 70, SWAP-70.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).