PharMolix/UniProtQA huggingface dataset:
Protein: AROB_CLOAB
Sequence: MKTLEMELGQNSYSIFIEKGIMNDIGKRISKLYSGEKIVLITDDNVNKFYGEKLEKNIKDFGYDVFKIVIKAGEKSKNIKTLTDIYSRLAEFRITRSDLIVTLGGGVVGDIGGFAAATYLRGISYIQIPTSLLAQIDSSIGGKVAVDLEQGKNLVGNFYQPKAVFIDPLFLKTLDIRFLHDGMGEVIKYGAIRDGELFKRLEEFKDDNELMDNIEYVIHACCRIKKQVVENDEKDNGERMILNFGHTIGHAVEEFFHYEKFTHGECVAYGMYSITKNSERLGITKEGTTEKLKNIIKKYSLPFNIDNLKNERIYEIAALDKKSRGKFINLVLLKDIGDCFIEKVESKETYKYLRVV
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO1_BACC4
Sequence: MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFEIFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAANGQSLLEKAMSELSDADLKAIPAKTVWPDAPEGIHTALDVIHRLKDVYTKSLAYEFSHIQDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGVDMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAVANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSGLPDQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSYDSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRMLFKKDFLIDLIGYRRYGHNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEVETITQFTQEQLKSDYAQVPPADTSDATIHVKVPDVVAKGIQSIDTGVEIDSLRAINEGLLSWPEGFNVYPKVKKILERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTNETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQALFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSAAQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGMKPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFKNLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQELIVAHALDVKYNFRQDKQEIEVYSN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: CPXM1_HUMAN
Sequence: MWGLLLALAAFAPAVGPALGAPRNSVLGLAQPGTTKVPGSTPALHSSPAQPPAETANGTSEQHVRIRVIKKKKVIMKKRKKLTLTRPTPLVTAGPLVTPTPAGTLDPAEKQETGCPPLGLESLRVSDSRLEASSSQSFGLGPHRGRLNIQSGLEDGDLYDGAWCAEEQDADPWFQVDAGHPTRFSGVITQGRNSVWRYDWVTSYKVQFSNDSRTWWGSRNHSSGMDAVFPANSDPETPVLNLLPEPQVARFIRLLPQTWLQGGAPCLRAEILACPVSDPNDLFLEAPASGSSDPLDFQHHNYKAMRKLMKQVQEQCPNITRIYSIGKSYQGLKLYVMEMSDKPGEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGNPRVTRLLSEMRIHLLPSMNPDGYEIAYHRGSELVGWAEGRWNNQSIDLNHNFADLNTPLWEAQDDGKVPHIVPNHHLPLPTYYTLPNATVAPETRAVIKWMKRIPFVLSANLHGGELVVSYPFDMTRTPWAARELTPTPDDAVFRWLSTVYAGSNLAMQDTSRRPCHSQDFSVHGNIINGADWHTVPGSMNDFSYLHTNCFEVTVELSCDKFPHENELPQEWENNKDALLTYLEQVRMGIAGVVRDKDTELGIADAVIAVDGINHDVTTAWGGDYWRLLTPGDYMVTASAEGYHSVTRNCRVTFEEGPFPCNFVLTKTPKQRLRELLAAGAKVPPDLRRRLERLRGQKD
What is the function of this protein?
May be involved in cell-cell interactions.  No carboxypeptidase activity was found yet (By similarity).
What are the official names of this protein?
Probable carboxypeptidase X1, Metallocarboxypeptidase CPX-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TTDB_METJA
Sequence: MEYTFNKLTKKDVKKLKVGDIVYLNGKIYTARDEAHLKIIEMLKSNEKLPFDLNESIIYHAGPIMKKVNDSWVCVSIGPTTSARMNDVEEEFIKLTNISAIVGKGGMKKELLKTFEDYGVVYLAAPGGCAALLANSVKRVDNVYFLDELGMPEAVWELEVNNFGPLIVAMDSHGNSIYEEVNKKVYEKLNELIGL
What are the official names of this protein?
Putative L(+)-tartrate dehydratase subunit beta, L-TTD beta.
What is the protein family that this protein belongs to?
Belongs to the class-I fumarase family.
Protein: LKHA4_ASPTN
Sequence: MATTINPPRDPNTLSNYNNWLSTHITANFDILFDQKKLVGNVIHKLKSITNAESTDIVLDTSHVDVTDVKVDGKPSVWELLPPVKPYGTALKIKLDQGVKMDEIVHVDISVKTTEKCTALQWLTPAQTSNKKHPYMFSQCQAIHARSIFPCQDTPDVKSTIDFNITSPLPVIASGLLVRDASGAPQTGGKNLYQFHQKVPIPSYLFALASGDISEAAIGPRSVVATSPDKLRECQWELEADTENFINAIEKIVYPYVWGEYNVLILPPSFPYGGMENPIFTFATPSIISKDRENVDVIAHELAHSWSGNLVTNASWEHFWLNEGWTVYLERRILAAVHGEAYRHFSAIIGWKALSDSVDHFGHDHEFTRLITDLKGKDPDDAFSSIPYEKGFNFLFHLENLVGKQKFDQFIPHYFTKFKGKSLDSYEFKATILDFFKSDAEASKLLNELDWDTWFYAPGLPPKPKFDTSLVDVVYDLAKKWQSIPESSFKPQPSDIKDLTGNQIVVFLEQVLLFERPLAPELSKLMGEVYGLAKSANIEVANLYFRVGLNAGDESVFEPTADLLGKIGRMKFVRPLYRNLQKVNRPLAIETFEKNKDFYHPICRAMVEKDLFGKKDA
What is the function of this protein?
Aminopeptidase that preferentially cleaves di- and tripeptides.  Also has low epoxide hydrolase activity (in vitro).  Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
What are the official names of this protein?
Leucine aminopeptidase 2, Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EMC3_YEAST
Sequence: MLLDDQLKYWVLLPISIVMVLTGVLKQYIMTLITGSSANEAQPRVKLTEWQYLQWAQLLIGNGGNLSSDAFAAKKEFLVKDLTEERHLAKAKQQDGSQAGEVPNPFNDPSMSNAMMNMAKGNMASFIPQTIIMWWVNHFFAGFILMQLPFPLTAKFKEMLQTGIICQDLDVRWVSSISWYFISVLGLNPVYNLIGLNDQDMGIQAGIGGPQGPQGPPQSQVDKAMHAMANDLTIIQHETCLDNVEQRVLKQYM
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 3, Altered inheritance rate of mitochondria protein 27.
What is the protein family that this protein belongs to?
Belongs to the EMC3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ELK1_RAT
Sequence: MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVSPSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
What is the function of this protein?
Transcription factor that binds to purine-rich DNA sequences.  Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131).  Induces target gene transcription upon JNK-signaling pathway stimulation (PubMed:17156131).
What are the official names of this protein?
ETS domain-containing protein Elk-1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GDF8_CANLF
Sequence: MQRLQICVYIYLFVLIVAGPVDLSENSEQKENVEKEGLCNACMWRQNTKSSRIEAIKIQILSKLRLETAPNISRDAVRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETVIAMPAETDLLMQVEGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: DHOM_MYCBO
Sequence: MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVGARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL
What are the official names of this protein?
Homoserine dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the homoserine dehydrogenase family.
Protein: MSD1_AMARI
Sequence: MSDINATRLPIIIVLGLIIPLCVSDIEMILTRGER
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: PA2HL_VIPAA
Sequence: MRILWIVAVCLIGVEGSVIEFGKMIQEETDKNPLTSYSFYGCHCGLGNKGKPKDATDRCCFVHSCCYAKLPDCSPKTNRYEYHRENGAIVCGSSTPCKKQICECDRAAAICFRENLKTYNKKYKVYLRFKCKGVSEKC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity. Snake venom phospholipase A2 homolog that Is very active in inducing myonecrosis in vivo and shows a potent calcium-independent membrane-damaging activity in vitro, most probably by binding and incorporating in the membrane.  Also acts as a presynaptic neurotoxin.  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog ammodytin L, AMDL, AtnL, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. S49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CSPL6_SORBI
Sequence: MEASRVKPGFNGVGMAAGSVNGSSRRPGPGLGYGYGYYMGSGAAAGGSGRAAQAPVDGCSVALRVFVVASTLVSAVVMGVDRQTRTIQITITDALPPLEVPLTANWSYSSAFVYFVVANAMVCLFSAAALAACRSRAAMVPVMVGDLLALALLYSAVGAAAEFGILGERGNSHVRWAKVCNVYGRFCDRAMAAVIVSLIGAFANLVLLMLNILTIHKSSSYY
What are the official names of this protein?
CASP-like protein 1E1, SbCASPL1E1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METN2_BURP1
Sequence: MAQLLDSPGFIERSAAVPHKAAAAPATRDAAAPAAVPGAAVSFELVGKVFDGPRGPAAALREVTLDIARGGVFGVIGRSGAGKSTLLRLVNGLERPTSGAVRVNGVDVGTLDERGLVALRRRIGMVFQHFNLLSAKTVAQNIGLPLKIAGVPKAERARKVDALLDLVGLAAKRDAYPASLSGGQKQRVGIARALVHDPALLLCDEATSALDPETTQSILALLADINRRLGLTIMLITHEMEVIRAVCDTVAVVEQGEVVETGPVWRVFGDPRHGATRALLRTLAHDLPADLAARLRPLDGAAPLPCGAQLLLDVRYTGASGGEPDLGALTAALARNVGDAVHFVHGGLDRIQGRVQGRLVIAASLAARGAASPDRIAAALAAARRHANRVEVLGYV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATPA_LACLA
Sequence: MAIKANEISSLIKKQIENFTPDFEVAETGVVTYVGDGIARAYGLENAMSGELVEFSNGVLGMAQNLDATDVGIIVLGDFLSIREGDTVKRTGKIMEIQVGEELIGRVVNPLGQPVDGLGELNTGKTRPVEAKAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTSVAIDAILNQKGQDMICIYVAIGQKESTVRTQVETLRKLGAMDYTIVVTASASQPSPLLYIAPYAGAAMGEEFMYNGKHVLVVYDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDLGGGSMTALPFIETQAGDISAYIATNVISITDGQIFLENDLFYSGVRPAIDAGSSVSRVGGAAQIKAMKKVAGTLRLDLASFRELEAFTQFGSDLDEATQAKLNRGRRTVEVLKQPLHKPLAVEKQVLILYALTHGHLDDVPVDDVLDFETKMFDFFDANYAELLNVITETKDLPEEAKLDEAIKAFKNTTNY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURC_BIFLD
Sequence: MSQDQPIVLDPTYASFDAAARPADLGATHFIGIGGAGMSVLAEMLHAEGVAVDGSDRAHSAKTDRLETLGITVEFGQRAENVAQAETVVYSSAIKPDNPEIVAAHAAGKRIVHRSDILALLMNGKRAVTVAGAHGKTTTSSMLSHILVNAGADPSYAIGGFIQGPDGTTLDGGHAGKGDILVAEADESDGSFAKYHPTIAIITNCEADHLDHYGDEAHYRAAFVAHAGRATGHVIISIDDPDGLAVLEALPADVKSHTVAYGTTARESLPDLGGAAYVWIASESETAGSGVEQLTLHLPAAVTAGEPVSQSVALKVPGVHNARNAAAAISAAVLLGVSPADAANAAGTFLGAARRFQVRGTVKQVTVVDDYAHHPTEIAALLDAARRRYPDSTIRVIFQPHLFSRTKFFAHQFAKSLAKADDVIITGIFPAREKQADFPDISPSTIVDAAAGLKDASAGTWIQPVEDMCLAAKMMAMRAHHGDVIFTVGAGDITDMDQVLLTALEAHRESCE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_PLETE
Sequence: MAPQTETKAGAGFKAGVKDYRLTYYTPEYQVKETDILAAFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYVKTFQGPPHGIQVERDKLNKYGRSLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQAFMRWRDRFLFVAEALYKSQAETGEIKGHYLNATAGTCEEMLKRAECAKELGVPIIMHDYLTGGFTANTTLAHYCRDHGLLLHIHRAMHAVIDRQRNHGMHFRVLAKALRLSGGDHLHSGTVVGKLEGEREVTLGFVDLMRDDYIEKDRSRGIYFTQDWVSLPGTMPVASGGIHVWHMPALVEIFGDDACLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAREGGDVIRAACKWSPELAAACEVWKEIKFEFDTIDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RCF1_LACTC
Sequence: MSHLPSSFDGAEQDVDEMTFLEKMTFHCKQQPLVPLGTLATTVAVILAAQNVRSGNKRKAQKYFRWRVGLQGATLVALVAGSFIYGTSQKERQSKEDALREKAKLREKLWIQELERRDEETQLRKKRAELARSRAKELEQETQGLQQELRDLQAKTSSSK
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ENO_PLAYO
Sequence: MIINPKNYEHIFYSRGNPTVEVDLETTLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQQAIKNINEIIAPKLIGLDCREQKKIDNMMVQELDGSKTEWGWSKSKLGANAILAISMAICRAGAAANKTSLYKYVAQLAGKNTEKMILPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEAMRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNAHEALDLLVASIKKAGYENKVKIAMDVAASEFYNSETKTYDLDFKTPNNDKSLVKTGQELVDLYIELVKKYPIISIEDPFDQDDWENYAKLTEAIGKDVQIVGDDLLVTNPTRIEKALEKKACNALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLFRIEESLGANGSFAGDKFRLQLN
What is the function of this protein?
Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity).  In addition to glycolysis, involved in various processes such as parasite development and invasion (By similarity).  Plays an essential role during ookinete invasion of the mosquito vector midgut by mediating the interaction of the ookinete with the midgut epithelium and, further, by binding to mammalian host plasminogen in the blood meal, whose conversion to active plasmin promotes the invasion process (By similarity).
What are the official names of this protein?
Enolase, PfENO, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell surface. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole. Note=Partially localizes to the nucleus in rings and trophozoites. Localization to the nucleus and food vacuole is higher in early and mid-stage trophozoites compared to the late-stage trophozoites and schizonts (By similarity). In the nucleus, localizes to heterochromatin region (By similarity). In rings, nuclear localization is dependent on the actin cytoskeleton (By similarity). In the trophozoite food vacuole, colocalizes with hemozoin, a product of heme detoxification (By similarity). Localizes to the cell surface of merozoites (By similarity). In gametocytes, predominantly localizes to the actin cytoskeleton (By similarity). In sporozoites, localizes to punctate structures beneath the cell membrane (PubMed:19642995). Localizes to the cell surface of ookinetes, especially on the apical pellicle complex that is involved in invasion (By similarity). When phosphorylated at Thr-337, localizes to the cytoskeleton (PubMed:24009698). When phosphorylated at Ser-40, localizes to the cytoplasm (By similarity). When ubiquitinated at Lys-136, acetylated at Lys-131 and Lys-373 and phosphorylated at Tyr-137, localizes to the food vacuole (PubMed:24009698). When triubiquitinated at Lys-136, appears to colocalize with hemozoin in the food vacuole (PubMed:24009698).
Protein: ACCD_GEOTN
Sequence: MWKDLFVKKKKYAAIPSEPLRPEVPEGVMTKCPQCKKIMYTKELVKNLRVCLSCGYHHPMPARERIESVLDEGSFREYDAGMTSVNPLGFPGYIEKLEADRRKSGLNEAVVTGEGTLEGHPLAIAVMDSSFRMGSMGSVVGEKIARAVERAHEQRMPFLIFTASGGARMQEGVLSLMQMAKTSAALKRFSNDGGLFISVMTHPTTGGVSASFASLGDYNFAEPGALIGFAGRRVIEQTVREELPEDFQTAEFLLKHGQLDAVIHRHELKEKLAVVLAIHAGGGESGWWRN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA_ASPNC
Sequence: MAPSQLPPIFNPTSQDIEMLLAAQCHLGSKNLQSHMEPYLWKTRPDGVNVINIGKTWEKILLAARIIAAIDNPADICVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTDFVDVAIPTNNKGRHAIGLVWWLLAREVLRLRGTLASREVDWDVVVDLYFYRDPEAEENKEVVEEKVASAEEVGAGAIESGFAGENWDVAGAGAGVPGTAFAAASAAAGAASWEAEGGDWAASSAAPAGESWAEAQPTEAKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX16_CENTE
Sequence: MNYFILLFVATFLLLDVNCKKDGYPVDANNCKFECWKNEYCDELCKAKRAESGYCYKLKLSCWCEGLPDDEPTKTSDRCYGTGR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity).  Is possibly toxic to mice (PubMed:27130039).
What are the official names of this protein?
Beta-toxin Ct16.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_STRMU
Sequence: MKIDILTLFPEMFAPLEHSIVGKAQTKGLLEINYHNFRENAEKARHVDDEPYGGGQGMLLRAQPIFDTFDKIAAKKPRVILLDPAGQQFNQSYAEDLAQEGELIFICGHYEGYDERIKTLVTDEISLGDFILTGGELAAMTIIDATVRLIPEVIGKEASHQDDSFSSGLLEYPQYTRPYEYRGMKVPDVLLSGHHENIRLWRLEQSLRKTWERRPDLLEHYQFTQEEKQLLEKIKSEGSS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_MARN8
Sequence: MLDPKRVRTQTEEIARRLAIKNFEFDIATFEQLEERRRAIQVRTENLQSEQNKRSKSIGKAKAAGEDIKPLLEEVESLKQQRGDAEDELRSVQESLNAFFAGIPNLPDDDVPPGASEDDNVETRVWGTPREFDFEPKDHVALGEQLKGLDFEKATQLAHSRFAVMRGQLARLHRALAQFMLDQHTLQHGYTEAYVPYLVNANTLFGTGQLPKFEEDLFRTAGDNPLYLIPTAEVPATNLVADTILDDAELPLRLVCHTPCFRSEAGSYGRDVRGMIRQHQFDKVELVHIVRPDESTQALEELTGHAEKILQLLELPYRVVTLCGGDMGFSAAKTYDLEVWLPGQGKYREISSCSNTRDFQARRMQARWRNPDTGKPEPVHTLNGSGLAVGRAMIAVMENYQQADGSILVPEVLKPYMGGVERIQ
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.