PharMolix/UniProtQA huggingface dataset:
Protein: FBXW7_MOUSE
Sequence: MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924).  Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924).  Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924).  Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, RICTOR and probably PSEN1 (By similarity).  Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity).  SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459).  Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593).  Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018).  Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity).  The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity).
What are the official names of this protein?
F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7, F-box protein FBW7, F-box protein Fbxw6, F-box-WD40 repeat protein 6, SEL-10.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Chromosome. Note=Localizes to site of double-strand breaks following phosphorylation by ATM.
Protein: DPOE2_CHICK
Sequence: MEPERLRRRLGSAFRVRGLLLRAEAVKYLTETLESLNEEEFEDVIDKIIDAVEKQPLSTNMIELSTVEAAVQECSQALDETIKNVFNIIGAFDIPRYIYNPDRKRFVPLSMTNLPVPNLFGTARDKAELFRERYSILQQRTHRHELFTPAAVVIHPDDNRSKFQLKTVETLLGNTAKVREVIVLGMITQLKEGKYFLEDPTGVVQLDLSKAQFHSGLYTESCFVLAEGWYEDEVFHVNAFGFPPTEPSATTRAFYGNINFFGGPSSASVKASAKLKQLEDENEDAMFVFLSDVWLDQAEVLEKLHTMFSGYSSAPPTCFFFCGNFSSAPYGKNQIQSLKGSLKALADIICEYPSIHKSSRFVFVPGPEDPGPGSVLPRPPLAENITQEFRQLVPFSVFTTNPCRVQYCTQEIIIFREDLVNKMCRNCVRFPSSSMDIPNHFVKTILSQGHLTPLPLYVSPVYWAYDYALRVYPVPDMLVIADKYDPFTVTNTDCLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGL
What is the function of this protein?
Accessory component of the DNA polymerase epsilon complex (By similarity).  Participates in DNA repair and in chromosomal DNA replication (By similarity).
What are the official names of this protein?
DNA polymerase epsilon subunit 2, DNA polymerase II subunit 2, DNA polymerase epsilon subunit B.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase epsilon subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y5858_PSEAB
Sequence: MLLHIPAIFTAEEVSRIRAALEQAEWADGKATAGYQSAKAKHNLQLPQDHPLAREIGEAMLQRLWNHPLFMSAALPLKVFPPLFNCYTGGGSFDFHIDNAVRDVHGGRERVRTDLSSTLFFSDPEDYDGGELVIQDTYGLQQVKLPAGDLVLYPGTSLHKVNPVTRGARYASFFWTQSLVREDSQRTLLFEMDQSIQRLTHDVPDHPSLIRLTGTYHNLLRRWSEL
What are the official names of this protein?
PKHD-type hydroxylase PA14_58580.
Protein: SYA_RICRO
Sequence: MTKFTTEEVRSKFITYFKANNHTHVPASSLIPHNDPSLMFVNSGMVQFKNVFTGQGKRPYNKAVTSQKSLRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAAAYWKKIAGFGDDRIIKIKTNDNFWSMGDTGPCGPCSEIFYDHGEQIYGGLPGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVNNNYDIDLFQEIINFTENIVKVKAEGEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAHMLGSKEPLMYKLLPKLVDLMGNVYPELKRAESFISSILEQEEIRFKATLERGLKLLTEETETLTKGNKLSGEVAFKLYDTYGFPLDLTEDILKNRDIAVDHKGFEEQMLMQKELARKSWLGSGESKTNQLWFDIKEQHGSTEFLGYTLNEAKCKIIALIKNNNLVNDIKEIDTQFLLISNQTPFYGESGGQIGDIGTISAKDSEVEVIDTLKYLGSIIVHKCILKKGQINVGENANFSIDIRYRQNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVTTTLMATEDAIKQGAMALFGEKYDSEVRVVKMGETSLELCGGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGEFVITLMRENDSLLKSIESSFKTNKNELITKVNNILERNKEVEKELEKTLLASLDLSIEQIEKQAAQITGIKLLYKKVGNIDNKILRQAAENLTKKVEDLIMVYIAEGIGKLSITVAVSKAITDKYNADIIAKKLSLFLGGSGGGGQASLAQAGGNDIGKLTNIHEKLYSLLTV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BH111_ARATH
Sequence: MDHHHHIASRNSSTTSELPSFEPACHNGNGNGWIYDPNQVRYDQSSDQRLSKLTDLVGKHWSIAPPNNPDMNHNLHHHFDHDHSQNDDISMYRQALEVKNEEDLCYNNGSSGGGSLFHDPIESSRSFLDIRLSRPLTDINPSFKPCFKALNVSEFNKKEHQTASLAAVRLGTTNAGKKKRCEEISDEVSKKAKCSEGSTLSPEKELPKAKLRDKITTLQQIVSPFGKTDTASVLQEAITYINFYQEQVKLLSTPYMKNSSMKDPWGGWDREDHNKRGPKHLDLRSRGLCLVPISYTPIAYRDNSATDYWNPTYRGSLYR
What are the official names of this protein?
Transcription factor bHLH111, Basic helix-loop-helix protein 111, AtbHLH111, bHLH 111, Transcription factor EN 66, bHLH transcription factor bHLH111.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPO19_YEAST
Sequence: MKKQILIVAAQSILCSTVFGERSNVGLSTEELGGDSILYFNEDPIVIEIDKKAIDKKTLEQLASTRDVVLTDLPDTLEFIDFNEYAKMKSKSDMLLEYINEYEFDDFERSSEGGLEEEEEEDLIYDFNAQAEDLGKLGSNIYEVVEEKNIVNTYDGNLINASTTESTTTIRPFVTSHSYVASSTPYSNISSLNEDYDNASNFLTPTTVALAVLLTILLFIQAY
What is the function of this protein?
Involved in sporulation.  Essential for completion of the nuclear division.
What are the official names of this protein?
Sporulation-specific protein 19.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: RS14_ACIB3
Sequence: MAKKGMINRELKREKTVAKYAAKRAELKATIANVNASDEERFEAMLKLQALPRNASPVRLRNRCGLTGRPHGYFRKFGLSRNKLRDTVMQGDVPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: IML1_ASHGO
Sequence: MQSNLLQFSNLRTGNLRLASTNRGSANGGGSSTMESGTSGAGSSSNKQVNMVIENNTLTIGGTEGKRAFGRRLQMDTSGLKVKSKVDQEELESAMKTPISGIPFFNQSSRRSYQFELSFHNTPVSDDCHVLIDVSQLPGAREGDLAELRTYHRSPGTRDKKVYFKIKSLDVEARRRSATTGLSILTGQLRYLLDLPSRSPVWVKLKSKNEHQADLVELHVKDCHVNRGDMWCISSTLLDTCVFTGQRVTYINALRLIVKAIYRNGKKVISGYVGNNTKVIFASESARIIFLIQITEEMWHFEQNGEKTFHKVVNSLFPRILKRWKDIGTYHTITIVFCASVDESGQSFRNIPPGVRLKNTKDYFRIVVDRVNILYWDEIMKTLRKEFMQIIGDLRNTQTDDGGGPIRWSFTPVIKSNILETINFATTLLADQFRVPDLKHTVTHVIIISPGTGLYDVNYDLLKVTCRKLLSLEIAVDLICLSRAPLHIVPLFRYIDYQGELCHSAPTWLSISFWDDNKKSQEWHPRCKIYDVQMMGVTERRDSEEVTLNYMNSALHTTSVTDFMDQYDKEVFDADKCYPLSNENRESTPLEDTSNIESTVLPKSGHEVQSIVWKPPRSSKPLVEPTTVQSVIVSLHQPGTINNSSEDDLTDTSSSNSSPEANESLALASLKNMTQISRGLTKRIVSKLIPDIKSKRSRHSIMATGNEHPRNDTYEDIEDIRKVDCHSTGTNITFLKPTFRSMDAEHYNPPDTVSSHGSAGTDSRRESLMFEKKSVLLDDFAKKKSNVNKYIKEKSLVDSLIHLDNPSVCFSGEVATMLIPDRWKDVYPKYVAKKYTKWRSFTTPAELPITTVHFPSLSDFESNFIFRNHSVSLNIDREVYGQTTFDLLRDMIYIRLLAGFQICTSELLKKVEATGSNEIHEQEIAKVLSKDNYMVAIYYMIIDNEVHRIKCGYNGTIDVQRFLRKNENKMMDTIAKYTPLVRTRYEHSYRPCKMDPLRISRTSLRWNQVDQILAGYYDSMMDSSKIGFRSKFVILPADIPPNTFSSTVNGRKETLSAEEIRLEGLRKLISSISKSRLRTNPEKATKASRKEEILPEVHFYTGSLFEYLADHHDNLEHVDSPAKDAQSADLSKFNRDAELSRLAYELQHGEKPIKLTNRKWHFKNHSSCFVGLEMVNWLIENFSDIDTRDEAVIYGQQLLTDGLFHHVDRRHGFLDGHYFYRISDPFVDIKIEKGSAESPLNSDPITINRRVSASTIISSKQNSSGMIQSKNGDSELLDRQSVNDEGKTIVISTAIDIDLDPAGNSHKLETCTVHYDQVHNPDHCFHIRIEWLTATPKLLDDLVTNWGRLCERYGLRLVEIPWHELCTIPSFDPTHSFIEATLAINPWTDPEFMDAEIFASQKYFYHVHLLESFGFLLDNRASRILQNERVSFNVVYSWGKPSFKYAQFIHNTGAYMAEIRENGDLFLAPNNLYLSRNGIGNSSGSLHLGPKSAIYSEKVMLDFKHVCEDYKKLRSVFWEARDKWQQTRNTLEEY
What are the official names of this protein?
Vacuolar membrane-associated protein IML1.
What is the protein family that this protein belongs to?
Belongs to the IML1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: PYRD_CROS8
Sequence: MYYPFVRKALFQLDPERAHEFTFQQMRRITGTPLEALLRQKVPSKPVSCMGLTFKNPLGLAAGLDKNGECIDALGALGFGSVEIGTVTPRPQPGNDKPRLFRLVEAEGLINRMGFNNLGVDNLVENVKKAHFDGVLGINIGKNKDTPVEQGKDDYLICMEKVFPYAGYIAINISSPNTPGLRSLQYGDALDDLLAAIKNQQQVLSQKHHKYVPVAVKIAPDLSLEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKYCDETGGLSGRPLQLKSTEIIRLLSQELQGRLPIIGVGGIDSVIAAREKIAAGASLIQIYSGFIFKGPPLVKEIVTHL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TA2R3_HUMAN
Sequence: MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLSDFIITTLALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLLSCGSTASLINEFKLYSVFRGIEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHTRQMLQNGTSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGHSFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
What are the official names of this protein?
Taste receptor type 2 member 3, T2R3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS14Z_GEOKA
Sequence: MAKKSMIAKQKRTPKFKVRAYTRCERCGRPHSVYRKFKLCRICFRELAYKGQLPGIKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: MINE_DESRM
Sequence: MLEFLNRFFGRESSSSKNVAKERLRLVLVHDRANVSPELLTSLKNDLIKVISNYMEIDDKALEVSLDGDDNQVALVANIPVKRLKRANSPVL
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: CPY1_CONPO
Sequence: MSKLGVVLFVFLLLLPLAAPQPVGDQPADQPADRNAEARARFLHPFQYYTLYRYLTRFLHRYPIYYIRY
What is the function of this protein?
Tyrosine-rich conopeptide that targets several channels/receptors that are expressed in Xenopus oocytes.  These targets are the voltage-gated potassium channels Kv1. 6/KCNA6 (IC(50) is 170 nM) and Kv1. 2/KCNA2 (IC(50) is 2. 0 uM), Nav1. 2/SCN2A (30% of inhibition), and N-methyl-D-aspartate (NMDA) receptor (GRIN1/GRIN2A/GRIN3B and GRIN1/GRIN2B/GRIN3B) (15% of inhibition).  In vivo, causes the marine worm N. virens to move very slowly in contrast to control worms, and causes seizures (at 5 nmol) and death (20 nmol) to mice when intracranially injected.
What are the official names of this protein?
Conopeptide Y-Pl1, CPY-Pl1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily. Conopeptide Y family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_ECOL6
Sequence: MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNKAA
What is the function of this protein?
In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity.
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: KPRS_SHEON
Sequence: MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKKLDNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHGANRVFAYATHPVFSGKAAENITNSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFSH
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PILB_THET8
Sequence: MSVLTIGDKRLGAALLDAGLLTDEELQRALERHREVGGSLAEVLVDMGLLSERRIAQTIEDRFGIPLVELHRVEIPPKVKALLPAEKAKELKAIPFALDEEAGVVRVAFLNPLDTLSLEEVEDLTGLVVEPYQTTKSAFLYALAKHYPELGLPVPPPPSGEGQKDLKLGELLLQKGWISREALEEALVEQEKTGDLLGRILVRKGLPEEALYRALAEQKGLEFLESTEGIVPDPSAALLLLRSDALRYGAVPIGFQNGEVEVVLSDPRHKEAVAQLLNRPARFYLALPQAWEELFRRAYPQKNRLGEVLVQEGKLSREALKEALEVQKGLPRAKPLGEILVELGLARPEDVEEALQKQRRGGGRLEDTLVQSGKLRPEALAQAVATQLGYPYVDPEEDPPDPGAPLLLPEDLCRRYGVFPHRLEGNRLVLLMKDPRNILALDDVRLALKRKGLNYEVAPAVATEAAITKLIERFYGKAELSEIAKEFAKKQAEEEVPSPLELDESAAQKFVKQVIREAFLQDASDIHIEPRQNDVQVRLRIDGALRPYSTLPKGALNAVISVVKIMGGLNIAEKRLPQDGRVRYREGAIDVDLRLSTLPTVYGEKAVMRLLKKASDIPEIEDLGFAPGVFERFKEVISKPYGIFLITGPTGSGKSFTTFSILKRIATPDKNTQTIEDPVEYEIPGINQTQVNPQAGLTFARALRAFLRQDPDIIMVGEIRDSETAKIATEAALTGHLVIATLHTNDAAQAITRLDEMGVEPFNISAALIGVLSQRLVRRVCEHCKVEVKPDPETLRRLGLSEAEIQGARLYKGMGCERCGGTGYKGRYAIHELLVVDDEIRHAIVAGKSATEIKEIARRKGMKTLREDGLYKALQGITTLEEVLARTIE
What is the function of this protein?
ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (By similarity) (PubMed:29717025).  Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:27667690).  PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (By similarity).
What are the official names of this protein?
Type IV pilus assembly ATPase PilB.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Displays polar localization.
Protein: RL17_ANAMM
Sequence: MRHGISCRKFSRPTAHRLSMLANPAVSLIRHERIVTTVAKAKDLRPFVERLVTVGRRLAKKDPVRGRRLLLSKMGGDLDAVNKLLDVLAKRYARRPGGYTRILKNGFRAGDCAPIAIMEFVDRKEGEPKKVAEG
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: NDK_NOCFA
Sequence: MTEQTLVLIKPDGVSRGLVGEVLARIERKGLKIAALELKQVSDELAREHYAEHADKPFFGSLIEFITSGPVVAAVLEGPRAIAAFRQLAGGTDPVEKAAPGSIRGDFGLETQYNLVHGSDSPESAKREIGLWFPEFPVA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH1_MYCSS
Sequence: MPEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQDDKPDLVFEATSAYVHRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVSSSSAGPGTRANIDEFTKTTSKGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVPGYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKESLSLAGGAQA
What are the official names of this protein?
Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase [acetylating] 1.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: BUD17_YEAST
Sequence: MTSTLHTTKKVLSIQSHVIHGYVGNKAATFPLQYRGWDVDVLNTVQFSNHSGYAHFTGFKCSTEELVDIVEKGLIGSLRIKYDAVLSGYLPNVQALQKVAGIVGQLCEGSENVKWILDPVLGDNGRLYVDRECVAVYQDILQNFKIFLATPNQFEMELLVGMSIRTLDDAKQAFKLFHKKYPRVSRIVVTSLELSEFLSNDTYVVAGFDCSASEEIFFYEIPKINAKFSGSGDLISAMLTDSLLGDRRCTQLSLSASLGQVLWLVTSILQKTYDLNIAERGPQDSTIDIKDLKLIQCRDILKQDLIPSIGKPKTIKI
What is the function of this protein?
Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity).  Important for bud site selection.
What are the official names of this protein?
Putative pyridoxal kinase BUD17, Bud site selection protein 17.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATG18_PHANO
Sequence: MNFVTFNQDHSHLGVGTSNGYRVYTTDPFNKQSESREGDVSSLEMLFSTSLVALTLSPRVLRIQNTKGKRHSTICEMTFRTAILAMRLNRKRLVVVLESELYIYDISNMQMLRTEKTSPNPNAICALSASSENNYLIYPLPTKAAPATFQPPSHAPPKSDHIAPTSGEILIYDATKMEAVNVIEAHNSPLSCIALNNDGTLLATASEKGTIIRVFSIPDAQKLYQFRRGSIPARIFSMSFNSTSTLLSVSSATETVHIFRLGAPNTSRSNSISSGPTTLLSTSHQRSSSRTSEDISDEFGSSTADMAASERKPLNPTFASMIRRTSQTVGKSFAATVGGYLPSAVAEIWEPSRDFAWVKVPRSPNAASAGPVRTVVALSNNGPQIMVVTSEGNYYVFNVDLEKGGEGTLYKQYS
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Necessary for proper vacuole morphology.  Plays an important role in osmotically-induced vacuole fragmentation.  Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy.  Involved in correct ATG9 trafficking to the pre-autophagosomal structure.  Might also be involved in premeiotic DNA replication (By similarity).
What are the official names of this protein?
Autophagy-related protein 18.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: Y1212_LEUMM
Sequence: MTVNIYDNANEMANILTETQQYIAWQNAFNAIQNDTDSKALFGEFQEIQMAVQQMMQSQQQPKPEQEKEWDAVAAKVQKDEKINALMEAEQALNTLLTELNDIVTKPVAEAYSKLQK
What are the official names of this protein?
UPF0342 protein LEUM_1212.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: Y5838_HAHCH
Sequence: MTDSQKEAPKIEFPCDYPLKVIGVAGPDFQEVVATIVRAHAPEFDASSIDALDSRNGKYLSLRFSIQAQSEEHIRRLFLDLKAHSAVQMVL
What are the official names of this protein?
UPF0250 protein HCH_05838.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: YON7_SCHPO
Sequence: MSLNDFLQTLSNAVGEKNSNTLEKCIILDPSEPSFQQLSKTLFLDRKGKNKLNGTIQKEFGRIRGWKELVTTYFEYVENAASSPDQRKWELLQNLYSNLTTCFSHIDGAWLCTIVKRVSKLYVKLSLQLDTSTPTLEDSFDGNGFIQRKYVSDASRNVLRTFNSILSDRQQNINPSKKDAIFCIANLLCLLYFRLKQIRLCQTIQANVISSGADISRATMAELVTFRYYLGRCHLYQRKIHQAKDHLLFSFLQCPDECYHQKRLSLIYLTTCLLILGKSPTKGLLEKYKLTAAFEPLIKALKSGDIKSFRLSLEDNSRRKWFIKRGIYLTLLDRCEIILWRNLFRKVFLFTFEQSQKTPHVSGSYLLTAARLSTNDNSYDMDDVECICVSLIDQGYIKGYIIHASSTLVLKKDPSFGFSVIESLMPIARNDHAEKEFFHANA
What are the official names of this protein?
PCI domain-containing protein C1105.07c.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope.
Protein: QUEC_SALHS
Sequence: MKRAVVVFSGGQDSTTCLAQARHQYDEVHCVTFDYGQRHRAEIDVARALALKLGTRAHKVLDVTLLNELAVSSLTRDSIPVPDYEPNADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVNLGMAKDIRFETPLMWIDKAETWALADYWGQLDLVREETLTCYNGIKGDGCGHCAACNLRANGLNHYLSNKAAVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PYRD_SHIDS
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNFGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEDELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CPFC_STAA8
Sequence: MTKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFSVGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRDLYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIIDEIKSIF
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:25908396).  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III (PubMed:25908396).  It can also insert iron into protoporphyrin IX, but it has a much stronger preference for coproprophyrin III as the substrate (PubMed:25908396).
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.