PharMolix/UniProtQA huggingface dataset:
Protein: XERC_RHOCS
Sequence: MTGGVPSLGFACQPDAAEALERWGRWLEHERGASTHTLRSYRADLAGFLAFVAEHRGRPPGLNDLGALDLGAFRAWLAARAADGAGAATRSRGVSGVRSFFRWADRSGLLHNPAIALLTAPKAQRPLPRPLAADDAALLLEEAAAVPEAPWIGLRDRALFTLLYGCGLRISEAIGLNRSDLPAGAASVRVLGKGGKQRDVPVLPAVREAVAAYLAAVPWGGGRAAPLFVGAKGDRLSPDVARRQMRHLRALLGLPDSTTPHALRHSFATHLLGGGADLRAIQDLLGHASLSTTQRYTDVDAEHLLSVYETAHPRARRQGHQTVRSVCDALPPRLRNQESER
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIS1_GLOMM
Sequence: MKMVLSQRQREELNQAIADYLGSNGYSSALEAFRKEADISGEAERKIVGLLEKKWTSVIRLQKKVMELEAKLSEAEKEVIEGAPSRAKRSPGEWIPRPPEKFSLSGHRASITRVIFHPTYSLMLSASEDAVIKIWDFETGEYERSLKGHTSSVQDIAFDSQGKLLASCSADLSIKLWDFQQSYDCVKTMLGHDHNVSSVAFVPAGDYVLSASRDQTIKMWEVATGYCVKTYSGHREWIRMVRVHMDGNIFASCSIDHSIRIWSINSRDCKAELRAHDHTVECIAWAPDISTTHINEAAGSDNKKGHHQGPFLASGSRDKTIRVWDVGVGLCLFVLTGHDNWVRELTFHPGGKYLVSASDDKTIRVWDLRNKRFMKTLYAHQHFCTSVDFHKKLPYVISGSVDNTVKVWECR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: HXK5_ORYSJ
Sequence: MGKAAAVGTAVVVAAAVGVAVVLARRRRRRDLELVEGAAAERKRKVAAVIEDVEHALSTPTALLRGISDAMVTEMERGLRGDSHAMVKMLITYVDNLPTGNEQGLFYALDLGGTNFRVLRVQLGGKEKRVVQQQYEEVSIPPHLMVGTSMELFDFIASALSKFVDTEGDDFHLPEGRQRELGFTFSFPVSQTSISSGTLIKWTKGFSINDAVGEDVVSELGKAMERQGLDMKIAALVNDTVGTLAGGRYADNSVVAAIILGTGTNAAYVENANAIPKWTGLLPRSGNMVINTEWGSFKSDKLPLSEFDKAMDFESLNPGEQIYEKLISGMYLGEIVRRILLKLAHDAALFGDVVPSKLEQPFVLRTPDMSAMHHDSSHDLKTVGAKLKDIVGVPDTSLEVRYITSHICDIVAERAARLAAAGIYGVLKKLGRDKMPKDGSKMPRTVIALDGGLYEHYKKFSSCLESTLTDLLGDDVSSSVVTKLANDGSGIGAALLAASHSQYAEID
What is the function of this protein?
Fructose and glucose phosphorylating enzyme (PubMed:16552590).  Functions as glucose sensor for plant growth and photosynthesis (PubMed:19010999).  Is essential for pollen development, germination, and tube growth (PubMed:31671177).  Its activity is necessary for the starch utilization pathway during pollen germination and tube growth, as well as for starch biosynthesis during pollen maturation (PubMed:31671177).
What are the official names of this protein?
Hexokinase-5, Hexokinase I.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Protein: RAGE_HUMAN
Sequence: MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
What is the function of this protein?
Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed:27572515, PubMed:28515150, PubMed:34743181).  Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706).  These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses.  Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed:21829704).  Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed:19386136).  Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity).  Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677).  ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.  Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed:27572515).  Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed:34743181).  Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed:24081950, PubMed:28515150).
What are the official names of this protein?
Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Isoform 10]: Cell membrane; Single-pass type I membrane protein.
Protein: RS6_UREU1
Sequence: MAKYEIMLVVRGDLDQEQANKVANELKATLKNTEVKENNYEGVQQLAYEINKLKTAYRYVYNFETTDVSLINEFRRLAIINKNVLRHIIINLEKDYGYKATVNAKKVQRNEKRAEVYVRQKEEAERRAAERQAAYEAMKAEREAAGLPVKEFVKGANSKR
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LPXC_LARHH
Sequence: MIHQRTLKAPVTASGVGLHSGDRIRLTLRPAPPDTGIVFRRTDLPEAADILCSPELVNDTRLSSTLVTPDGVRVGTIEHLMSALAGLGIDNLYVEMTAQETPIMDGSAAPFIYLLQTAGIVEQPAKKRFIRVLEPVGVAEGDKWVRLEPYDGFQVSLEISFDHPAFRLAPQKVDIDFARTSYIDEIARARTFGFMYEVETMARMGLGRGGSLDNAIVIDDEFVLNRDGLRFPDEFVRHKILDAIGDLYIIGHPLIAAFSGYKSGHAMNNQLLRQLLARPSAWEYVTFSHSEDVPSSFHRIPHLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: TRIN1_MESSA
Sequence: RGWGSDEKKDREEEXEQQ
What is the function of this protein?
Inhibitor of serine proteases.  Can inhibit trypsin but is ineffective against chymotrypsin, papain and elastase.  Strongly inhibits the trypsin-like protease activity isolated from the third instar larva of P. truncatus, and also inhibits more weakly the trypsin-like protease activity isolated from the third instar larva of M. sexta.  Protects the plant by inhibiting proteases of invading organisms.
What are the official names of this protein?
Trypsin inhibitor HSTI.
Protein: NRDR_CLOAB
Sequence: MKCPFCGYSESKVVDSRSTEDNMAIRRRRECLECSKRYTTYEKVEDIPILVIKKDSSREFFDKSKVINGLIKSCEKRPVSRQQIEDIASDVEKSISNQMVTEVKSDAIGEMVMEKLKEIDEIAYVRFASVYRQFKDINTFMEEILNLVNKK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TRMB_SHEON
Sequence: MSEVTTAEFNEEGKYLRKIRSFVLREGRLTKGQAQAIETQWPTMGLDYSPAPLDLADVFGRKADTVLEIGFGMGASLVQMAQEAPELNFIGIEVHKPGVGSCLSDAAAAGVTNLRVYHHDAMEVLEHAIADGSLTRVQLFFPDPWHKKRHHKRRIVQAEFAELIRRKLKIGGVFHMATDWENYSEHMLEVMNVASGYKNQSADGTVVPRPDHRPLTKFEARGHRLGHGVWDLMFERIA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ACC2_ORYSJ
Sequence: MTSTHVATLGVGAQAPPRHQKKSAGTAFVSSGSSRPSYRKNGQRTRSLREESNGGVSDSKKLNHSIRQGLAGIIDLPNDAASEVDISHGSEDPRGPTVPGSYQMNGIINETHNGRHASVSKVVEFCTALGGKTPIHSVLVANNGMAAAKFMRSVRTWANDTFGSEKAIQLIAMATPEDLRINAEHIRIADQFVEVPGGTNNNNYANVQLIVEIAERTGVSAVWPGWGHASENPELPDALTAKGIVFLGPPASSMHALGDKVGSALIAQAAGVPTLAWSGSHVEVPLECCLDSIPDEMYRKACVTTTEEAVASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRTLFKQVQGEVPGSPIFIMRLAAQSRHLEVQLLCDQYGNVAALHSRDCSVQRRHQKIIEEGPVTVAPRETVKELEQAARRLAKAVGYVGAATVEYLYSMETGEYYFLELNPRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMNHGGGYDLWRKTAALATPFNFDEVDSKWPKGHCVAVRITSEDPDDGFKPTGGKVKEISFKSKPNVWAYFSVKSGGGIHEFADSQFGHVFAYGTTRSAAITTMALALKEVQIRGEIHSNVDYTVDLLNASDFRENKIHTGWLDTRIAMRVQAERPPWYISVVGGALYKTVTANTATVSDYVGYLTKGQIPPKHISLVYTTVALNIDGKKYTIDTVRSGHGSYRLRMNGSTVDANVQILCDGGLLMQLDGNSHVIYAEEEASGTRLLIDGKTCMLQNDHDPSKLLAETPCKLLRFLVADGAHVDADVPYAEVEVMKMCMPLLSPASGVIHVVMSEGQAMQAGDLIARLDLDDPSAVKRAEPFEDTFPQMGLPIAASGQVHKLCAASLNACRMILAGYEHDIDKVVPELVYCLDTPELPFLQWEELMSVLATRLPRNLKSELEGKYEEYKVKFDSGIINDFPANMLRVIIEENLACGSEKEKATNERLVEPLMSLLKSYEGGRESHAHFVVKSLFEEYLYVEELFSDGIQSDVIERLRLQHSKDLQKVVDIVLSHQSVRNKTKLILKLMESLVYPNPAAYRDQLIRFSSLNHKAYYKLALKASELLEQTKLSELRARIARSLSELEMFTEESKGLSMHKREIAIKESMEDLVTAPLPVEDALISLFDCSDTTVQQRVIETYIARLYQPHLVKDSIKMKWIESGVIALWEFPEGHFDARNGGAVLGDKRWGAMVIVKSLESLSMAIRFALKETSHYTSSEGNMMHIALLGADNKMHIIQESGDDADRIAKLPLILKDNVTDLHASGVKTISFIVQRDEARMTMRRTFLWSDEKLSYEEEPILRHVEPPLSALLELDKLKVKGYNEMKYTPSRDRQWHIYTLRNTENPKMLHRVFFRTLVRQPSVSNKFSSGQIGDMEVGSAEEPLSFTSTSILRSLMTAIEELELHAIRTGHSHMYLHVLKEQKLLDLVPVSGNTVLDVGQDEATAYSLLKEMAMKIHELVGARMHHLSVCQWEVKLKLDCDGPASGTWRIVTTNVTSHTCTVDIYREMEDKESRKLVYHPATPAAGPLHGVALNNPYQPLSVIDLKRCSARNNRTTYCYDFPLAFETAVRKSWSSSTSGASKGVENAQCYVKATELVFADKHGSWGTPLVQMDRPAGLNDIGMVAWTLKMSTPEFPSGREIIVVANDITFRAGSFGPREDAFFEAVTNLACEKKLPLIYLAANSGARIGIADEVKSCFRVGWSDDGSPERGFQYIYLSEEDYARIGTSVIAHKMQLDSGEIRWVIDSVVGKEDGLGVENIHGSAAIASAYSRAYKETFTLTFVTGRTVGIGAYLARLGIRCIQRLDQPIILTGYSALNKLLGREVYSSHMQLGGPKIMATNGVVHLTVSDDLEGVSNILRWLSYVPAYIGGPLPVTTPLDPPDRPVAYIPENSCDPRAAIRGVDDSQGKWLGGMFDKDSFVETFEGWAKTVVTGRAKLGGIPVGVIAVETQTMMQTIPADPGQLDSREQSVPRAGQVWFPDSATKTAQALLDFNREGLPLFILANWRGFSGGQRDLFEGILQAGSTIVENLRTYNQPAFVYIPMAAELRGGAWVVVDSKINPDRIECYAERTAKGNVLEPQGLIEIKFRSEELQDCMSRLDPTLIDLKAKLEVANKNGSADTKSLQENIEARTKQLMPLYTQIAIRFAELHDTSLRMAAKGVIKKVVDWEESRSFFYKRLRRRISEDVLAKEIRAVAGEQFSHQPAIELIKKWYSASHAAEWDDDDAFVAWMDNPENYKDYIQYLKAQRVSQSLSSLSDSSSDLQALPQGLSMLLDKMDPSRRAQLVEEIRKVLG
What is the function of this protein?
Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.
What are the official names of this protein?
Acetyl-CoA carboxylase 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: EGF_CANLF
Sequence: MLLPLIILWPVVFKCSFASLSDPENWNCPEVSPSGKGSPACVGPAPFLIFSHGISIFRIDLEGTNHEQLVADAGVSVIMDFHYNKERIYWVDPERQLLQRVFLNGTRQERVCNIEKNVSGMAINWINEELIWSNQQEGIITVTDMKGNNSRVLLRALNYPANVAIDPIERFIFWSSEVAVAGSLHRADLNGVEEKILLQTSERITAVSLDVLDKQLFWIQYSRDGSNSHIYSCNYDGGSVHLSKHLTQHNFFAMSLFGNQIFYSTWKKKTIWIANKHSGKDMVRINLDSSFVPPGGIKVVHPLLQPKAESGTWAPDQKLCKWKQGNCRGSTCGQDSKSYSCTCAEGYTLSQDGKYCEDVNECAFWNHGCTLGCENIPGSYYCTCPVGFILLPDGKRCHQLIACPSNTSKCSHDCVLTSDGPICFCPEGSVLEADGKTCSGCSSPDNGGCSQLCLPLSPVSWECGCFPGYDLQLDKQSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVFALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAIDWIDRKFYWTDSGKSLIEGSDLNGKHREIIIKEDISQPRGIAVHPMAKRLFWTDMGINPRIESSSLQGIGRLVIASSDLVWPSGITIDYVTDKLYWCDTKLSVIEMANLDGSKRQRLAQNDVGHPFAMAVFEDHVWFSDWTMPSIIRVDKRTGKNRVRLRGSMLKPSSLVVVHPLAKPGAQPCLYQNGGCEHICKERFGTAQCLCREGFVKAPDGKMCLALNGHQIPAVGSEADLSNHVTPGDVLPRSEGFEDNITESQHMLVAEIMVSDADDCAPVGCSTWAECVSEGENATCQCLKGFTGDGKLCFDIDECEMGITICPPTSSKCVNTEGGYVCQCSEGYRGDGIHCLDINECQLGMHTCGENATCTNMEGNYTCMCAGSLSEPGQICADSTPPSHPMEDSHYSVRNGYRECPSSYDGYCLYNGVCMYIEAVDRYACNCVFGYVGERCQHRDLKWELRHAGQGRQRQVAAVAVGVVVLVLLLLLGLGGAHCYRTKKLSSKNLKNPYEEPSREGSSSRPSDSEARMASFPQPWFVVIKEHQNLRNGSQPMALKDGESADVSQFSSPEPGSVKRTSWRNEHQLYKDTEQGCCTPPSSNRGTGSQSMEQSFSVPSYEAQPIALGVEKPQSLLSAKPLLQQRAPDPPHQMKLIQ
What is the function of this protein?
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.  Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
What are the official names of this protein?
Pro-epidermal growth factor, EGF.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL32_BACC2
Sequence: MAVPFRRTSKTVKRKRRTHFKLSVPGMVECPSCGEAKLAHRVCKACGTYKGKEVISK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: YG34_YEAST
Sequence: MRENAMSTKKLPYKLSGSSKITTSIPNDLIILRNNCINSLNSSSSKADSITCIDTWLKYTEGLLTHRYEANNDAALIEEEIAIALINVAVFYQDIGIETLYRAYESSQASNNLWTTSGTYLKRGLGLICFLGKNFQINTANDCQKMQVLNVLNQLSLEFQLLQQLGIVVLALSKLRSKISKDAVADLEPQELEELGKSSVFYAKLCIGSYSTASQCQGGRIVDALFMNYLQSLTYLFLSINQYNNDECGIAIGMLQESIKKLLNIVPNSQLKELDILSSTDITKKRDLIKMSFKRKIHGSTLKNQRIFEKKVPFSSKAYMMPLLKSSLDDFVIPLTILLRYRYQTTNENYSFKTVETDVSKLKELFPRGKSSDIEGTVWSFQDGHLTFADSNNATHNCGNYF
What are the official names of this protein?
Uncharacterized protein YGR122W.
Protein: SYK_YERPE
Sequence: MSEQKPQVAEQAQELNSELQARREKLAVLRGKGIAFPNDFRRENLSDQLHAEFDSKENEELEALNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDDLPEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDDMDKAVAIAESLGIKVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKEAGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQBI_BACSU
Sequence: MKIRGLDQFIQSLDRASRGGLKRKYEQWLESMGFEFLDIIQDEIIRTKTVDTRRLLNSFQKGDQDNIFSMTEGSLKLDVGTNLDYASYVNDGHFTIDPSKNQDRRWVPGRWKGDRFEYDPAEKNSGMLLKFRWVDGSGFWDNAMAIFQLMFERSLERKLQQWIYEEF
What are the official names of this protein?
Uncharacterized protein YqbI.
What is the protein family that this protein belongs to?
To B.subtilis XkdI.
Protein: YAJC_ECO57
Sequence: MSFFISDAVAATGAPAQGSPMSLILMLVVFGLIFYFMILRPQQKRTKEHKKLMDSIAKGDEVLTNGGLVGRVTKVAENGYIAIALNDTTEVVIKRDFVAAVLPKGTMKAL
What is the function of this protein?
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes.  While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
What are the official names of this protein?
Sec translocon accessory complex subunit YajC.
What is the protein family that this protein belongs to?
Belongs to the YajC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RS8_ACET2
Sequence: MQATDVIADMLTRIRNACSAKHETVDIPASNIKRAIANILLEEGYIKGIEEIDDGKQGVLRLKLKYTANKQNVISGLKRISKPGLRVYAGKSEIPKVLGGLGIAIISTSKGIMTDKKARAEGVGGEVLAFVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FOLD_RICPR
Sequence: MVNNIIDGKALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGIDTLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPSSIDENKILSAVLPSKDSDGFHPLNVGYLHSGINQGFIPCTALGCLAVIKKYAPNLNGKDAVIVGRSNIVGKPLSALLLQENCSVTICHSKTCNLSSITSKADIVVVAIGSPLKLTAEYFNPEAIVIDVGINRISHNKIAGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKNAIAL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TRAY8_ECOLX
Sequence: MKEPKSNIRKLIDIGGLIGR
What is the function of this protein?
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell.  It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations.  Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site.  Relaxosome formation requires binding of IHF and TraY to the oriT region, which then facilitates binding of TraI.  Also positively regulates tra gene expression (By similarity).
What are the official names of this protein?
Relaxosome protein TraY.
What is the protein family that this protein belongs to?
Belongs to the TraY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECY_HALSA
Sequence: MGWKEAAAPVLTRMPAVERPEGHVPFRRKMYWTGGVLVLYFFLTNVPLWGIQTAGNDFFGQFRSLLAGGQGTVLQLGIGPIVTASIVLQLLGGANLLGLDTDNDPRDQAIYQGLQKFLVGVMVVLTGAPMVFLGNFLQPSQQLAQSMPGGAFGVEVLIFAQIAAGGILLLFMDEVISKWGVGSGIGLFIVAGVSQSLVGGLVFWEGGVGSQGLLPTWFDIIVGNVSNMPPLLSGSGIEFLLMQAGILGLLTTLFIYVVVVYAESVRVEIPLSHARVKGARGRFPVKLIYASVLPMILVRALQANIQFLGQILNSTLASMPTWLGVYGGNGQVTGGLFYYLAPIYSPNAWMWWTSGATAARWQVLIRIAIDLSFMIIGGAIFAIFWVETADMGPDATARQIQNSGMQIPGFRKNQGVIEKVMERYIPQVTVIGGALVGLLAVMANMLGTIGNVSGTGLLLTISITYKLYEEIAEEQMMEMHPMMREMFGGGD
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY, Protein transport protein SEC61 subunit alpha homolog.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SIN1_RAT
Sequence: MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKTHPPSVPGDSGSEVQGSSGETQGYIYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPSSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKALKRRKGSQKISGPQYRLEKQSEPNIGVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEKSPSHAVFKLTYLSSHDYKHLYFESDAATVSEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
What is the function of this protein?
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.  mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.  Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity.  MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation.  Inhibits HRAS and KRAS signaling.  Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.  Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
What are the official names of this protein?
Target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Protein: EFTS_RICS2
Sequence: MSEINISAAAVKELREKTGAGMMDCKKALIETSGNFEEAIDFLRKKGLAAAAKKAGRIASEGLTAAKVDGLTGVVIEVNSETDFVARNEQFQDLVKDIANLAVIAKTIDTLKTFKMQSGKSVEEEIIENIATIGENLTLRRMDILEISEGAIGSYVHNEVVPNLGKISVLVGLASNAKDKAKLEALAKQIAVHVAGNNPQSIDDSSLDQALVERERKVFFEKSKEEGKPDNIIAKMVEGRIRKFFSEVVLLQQNFLFEPKLTVAEVIKNAEKELGAEIKIAKFIRYELGEGIEHEEKNFADEVAAITQG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y917_MYCBO
Sequence: MRTEDDSWDVTTSVGSTGLLVAAARALETQKADPLAIDPYAEVFCRAAGGEWADVLDGKLPDHYLTTGDFGEHFVNFQGARTRYFDEYFSRATAAGMKQVVILAAGLDSRAFRLQWPIGTTIFELDRPQVLDFKNAVLADYHIRPRAQRRSVAVDLRDEWQIALCNNGFDANRPSAWIAEGLLVYLSAEAQQRLFIGIDTLASPGSHVAVEEATPLDPCEFAAKLERERAANAQGDPRRFFQMVYNERWARATEWFDERGWRATATPLAEYLRRVGRAVPEADTEAAPMVTAITFVSAVRTGLVADPARTSPSSTSIGFKRFEAD
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mb0917c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.