PharMolix/UniProtQA huggingface dataset:
Protein: IF2B2_MOUSE
Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRRIQIRNIPPHLQWEVLDGLLAEYGTVENVEQVNTDTETAVVNVTYMTREEAKLAIEKLSGHQFEDYSFKISYIPDEEVSSPSPPHRAREQGHGPGSSSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEVPLKILAHNGFVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVRGTIEACANAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLPPPAGPRGVPPSPPYHPFATHSGYFSSLYPHHHFGPFPHHHSYPEQETVSLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQRYPQGVAPQRSK
What is the function of this protein?
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs).  This transcript 'caging' into mRNPs allows mRNA transport and transient storage.  It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).  Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity).  Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.  Binding is isoform-specific.  Binds to beta-actin/ACTB and MYC transcripts (By similarity).  Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity).
What are the official names of this protein?
Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, IGF-II mRNA-binding protein 2, VICKZ family member 2.
What is the protein family that this protein belongs to?
Belongs to the RRM IMP/VICKZ family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules (By similarity).
Protein: AROE_CHRVO
Sequence: MTDRYAVIGNPISHSQSPFIHEEFARATGQDISYERLFADIGRFNDVVGEFVASGGKGLNITLPFKGDAFRYASELTERARAAEAVNTLTFRDGKVYGDNTDGVGLVRDIVENLDYPIVGRRVLILGAGGAVRGVLEPILEQKPASLTIANRTVIKAEALAHHFARYGKVEAVGYAALEGRSFDIVINATSTSLNNEMPPLPHGVFTPRTLAYDMVYSTGLTPFLQRAQGENAGMLADGLGMLVEQAAESFSIWRGAQPETRKVTNMLREVLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CRTW_HAELA
Sequence: MHVASALMVEQKGSEAAASSPDVLRAWATQYHMPSESSDAARPALKHAYKPPASDAKGITMALTIIGTWTAVFLHAIFQIRLPTSMDQLHWLPVSEATAQLLGGSSSLLHIAAVFIVLEFLYTGLFITTHDAMHGTIALRHRQLNDLLGNICISLYAWFDYSMLHRKHWEHHNHTGEVGKDPDFHKGNPGLVPWFASFMSSYMSLWQFARLAWWAVVMQMLGAPMANLLVFMAAAPILSAFRLFYFGTYLPHKPEPGPAAGSQVMAWFRAKTSEASDVMSFLTCYHFDLHWEHHRWPFAPWWQLPHCRRLSGRGLVPALA
What is the function of this protein?
Converts beta-carotene to canthaxanthin via echinenone.
What are the official names of this protein?
Beta-carotene ketolase, Beta-carotene oxygenase.
Protein: AB1IP_HUMAN
Sequence: MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS
What is the function of this protein?
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.  Suppresses insulin-induced promoter activities through AP1 and SRE.  Mediates Rap1-induced adhesion.
What are the official names of this protein?
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 73, Rap1-GTP-interacting adapter molecule, RIAM, Retinoic acid-responsive proline-rich protein 1, RARP-1.
What is the protein family that this protein belongs to?
Belongs to the MRL family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
Protein: MNMG_HAEIE
Sequence: MFYTETYDVIVIGGGHAGTEAALAPARMGFKTLLLTHNVDTLGQMSCNPAIGGIGKGHLVKEVDAMGGLMAHAADKAGIQFRTLNSSKGPAVRATRAQADRVLYRQAVRTALENQPNLDIFQQEATDILIEQDRVTGVSTKMGLIFRAKSVVLTAGTFLAGKIHIGLENYEGGRAGDPASVNLSHRLRDLGLRVDRLKTGTPPRIDARTINFDILAKQHGDEVLPMFSFMGSVDDHPQQIPCYITYTNEQTHEVIRNNLDRSPMYTGVIEGIGPRYCPSIEDKVMRFSDRNSHQIYLEPEGLTSNEVYPNGISTSLPFDVQMGIVNSMKGLENARIVKPGYAIEYDYFDPRDLKPTLETKSISGLFFAGQINGTTGYEEAAAQGLLAGINAGLYVQEKDAWYPRRDQSYTGVLVDDLCTLGTKEPYRVFTSRAEYRLLLREDNADIRLTPIAHELGLIDDARWARFNQKMENIEQERQRLRNIWLHPRSEYLEEANKVLGSPLVREASGEDLLRRPEMTYDILTSLTPYKPAMEDKEAVEQVEIAIKYQGYIEHQQEEIEKQKRHENTAIPANFDYSKVSSLSNEVRAKLEQHRPVSISQASRISGITPAAISIILVNLKKQGMLKRGE
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_DECAR
Sequence: MIEDHLNTELAEIASAGLTRRRRVLETPCGRMATVDGTNLLNFASNDYLGLAGNADIARVLADGALQWGAGSGASHLVSGHLGPHELLEKEIAEFTGFPRTLTFSTGYLANLAVTPTLAGRGDAVFADKLNHASLIDAMQLAKANGAEVQRYPHNDVAALEKMLAASTAAHKIIVTDAVFSMDGDLAPLPLIFALAERYDAWLVIDDAHGFGVLGPHGEGSLGHFNLPASPRILLMGTLGKAAGVGGAFVAGSETAIEYLLQKGRSYIFTTAQPPAIACALAKSLQLIRDGDALRANLMDRIGQLRDGLAGLPMKLLPSPTAIQPLIVGDNDAAVALSKALWERGLWVPAIRPPTVPKGTARLRISVSAAHTEADIAQLIAALKELA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RL9_PELPB
Sequence: MKVILRNNVATLGDAGEVVAVKNGYANNFLIPQGMAIRATEGTLKALETEKKQQTKKIELQRKHAREHAQTIEQMSLKVYAKAGDSGKLFGTVTSADIADALKAQGIDIDRRKITIEAPIKSLGKYEADAKIFQDITVKVHFEVEAEGSEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: XERC_STAAB
Sequence: MNHIQEAFLNTLKVERNFSEHTLKSYQDDLIQFNQFLEQEHLQLNTFEYRDARNYLSYLYSNHLKRTSVSRKISTLRTFYEYWMTLDENIINPFVQLVHPKKEKYLPQFFYEEEMEALFKTVEEDTSKSLRDRVILELLYATGIRVSELVNIKKQDIDFYANGVTVFGKGSKERFVPFGAYCRQSIENYLEHFKPIQSCNHDFLIVNMKGEAITERGVRYVLNDIVKRTAGVSEIHPHKLRHTFATHLLNQGADLRTVQSLLGHVNLSTTGKYTHVSNQQLRKVYLNAHPRAKKENET
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5933_DICDI
Sequence: MSKPRQSTLDPEDKKYLEIPDSEVVLPAAVDSYLRQKLKDQSLKECSSHVAAFADCSKDKYISVVWECRELQQLMKNCLVEYTTSERLIGMKREWVDASKKRIYEKRLQKELESKEPTPKK
What are the official names of this protein?
Uncharacterized protein DDB_G0275933.
What is the protein family that this protein belongs to?
Belongs to the CMC family.
Protein: MUTS_HERAR
Sequence: MESTMSSASTNASPPSASEKHTPMMQQYLRIKAEHPETLLFYRMGDFYEVFFEDAEKASRLLGITLTQRGSSNGNPIKMAGVPFHAVDQYLSKLVKLGESIALCEQIGDPATSKGPVERKVLRVITPGTLSDSDLLPEKSEQPLLALYSTTQRKTITIGLAWLSMASGALKLMEFTTDARNAATRLKHELERIAPAEVLLPGSIDGPDSDYAFAKNTTVPDWHFDIAHGSKALHEQLKVSTLTGFGAEHLNAAIGAAGALLRYAQATQGKGLQHVRALTVETENEFIGLDAATRRNLELTETIRGQDNNSATLFSLLDHCRTAMGSRLLRHWLHHARRDQAVARARHAAINALMRTDACTGLASTLASVPDVERIATRIALQSARPRDLAGMRGGLQQLPSLRAYVSMCNQDADAPLLKTIHDALATPSECLDLVERAIALEPAAMVRDGGVIARGFDAELDELRGLSENAGQFLVDLETRERTRTGINNLRVEYNKVHGFYIEVTHGQTDKVPDDYRRRQTLKNAERYITPELKAFEDKALSAQERALAREKYLYDQVLQQMAQHIGTLQNIAHALAQLDTLVALAEHALRHNWCAPQLIAEPTIAIEQGRHPVVENHIERFIANDCLLNNESRLLLITGPNMGGKSTYMRQVALITLLAYVGSFVPATSATIGPIDRIFTRIGAADDLAGGRSTFMVEMTESAAILNGATENSLVLMDEVGRGTSTFDGLALAWAIARHLIDSTRSFTLFATHYFELTQLPEVHPSAANVHLSAVEHKDSIVFLHAVQAGPASQSYGLQVAQLAGVPQAVIRAARKHLATLEANSMQATPQFDLFADPDHLIPTSDVETAMAQPSALDEALADINPDALSPRDALDALYRLKELSNQHREK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: UREE_YERIN
Sequence: MILIEHILGNVKKDPVWQAKLKNATVDLLVLDQREAQKSRCRKSTLQGLDLGISLDRHVVLADGDVLTWDEESNVAVVVQIHLRDVMVIDLSELKNRSADELIKTCFELGHALGNQHWKAVTKNNEVYVPLTVATTMMDSVMRTHGFQHLPFRFVKGAEILPLLTNSEARLLFGGAEDTDTHVHVASPLDEPHGSGLHIHSIHSHGDGHSHDHDHSHGDHDSDHKH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_PARL1
Sequence: MILFPAIDLKDGQCVRLVHGLMDQATVFNDDPAAQARAFEEAGFEYIHLVDLNGAFEGKPVNAAAVESILAAISIPAQLGGGIRDLATIEMWLEKGVRRVIIGTAAVKNPALVIEACRKFPGRIAVGLDAKGGRVATEGWADVSDLTVLDMAGRFEDAGVAAIIYTDIDRDGALQGLNIEATVSLADAISIPVIASGGLSSIEDLKKLIAANCSGIEGAISGRALYDGRLDPSEALKLLRGVA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_STRMK
Sequence: MKADIHPNYRDVVFHDVTSDFKILTRSTMATKETIQWEDGNEYPLVKVEISSASHPFYTGKHKVIDTSGRIDKFQKRYAR
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RL13_PSEA7
Sequence: MKTYTAKPETVQRDWFVVDAAGQTLGRLATEIARRLRGKHKPEYTPHVDTGDYIVVINAEQVRVTGAKTTDKMYYHHSGFPGGIKSINFEKLIAKAPERVIETAVKGMLPKNPLGRDMYRKLKVYKGANHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NS1_I02A5
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQELGDAPFLDRLRRDQKSLRGRGNTLGLDIETATRAGKQIVERILEEESDEALKMPASRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIKMDQAIMDKTIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTVRVSETIQRFAWRSSDEDGRLPLPPNQKRKMARTIESKV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: MURG_BACFR
Sequence: MNKENNKEGQGDALRVIISGGGTGGHIFPAVSIANAIKELRPDAQILFVGAEGRMEMQRVPDAGYQIIGLPVAGFDRKHLWKNVAVLLKLVRSQWKARNIIRQFRPQVAVGVGGYASGPTLKMAGMMGVPTLIQEQNSYAGVTNKLLAQKARRICVAYDGMEKFFPANKIIMTGNPVRQNLLAEKPEREQAIRSFGLNPEKKTILILGGSLGARTINNTLIAGLQLIRRTTDVQFIWQTGKIYHQQVTEAVKAAGEIPNLFVTDFIKDMAAAYAAADLVISRAGAGSISEFCLLNKPVILVPSPNVAEDHQTKNALALVNKQAAIYVKDAEAENKLLPVALETIANAEKLSELSENIAHLALPDSAVVIAKEVIKLAQQS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RSMI_BORGP
Sequence: MLYIVGTPIGNLEDITYRAVDVLKSVNVIFAEDTRVTIKLLSRYKINKKMISCNAVTENKKIRLLLDYLAKGDSVAFVSDAGTPGLSDPGSLLVAAAFREGYKVCPIPGVSSFNTIVSVNPFRDKSVLFEGFLPNKGLKRFKKIAELYKRGDAFVLLESGHRLLKLLVEISSVSLDAKILIGREMTKIYEEYQIGKPLELKKYFESSKEKVKGEFTILVSRSSS
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_BACC1
Sequence: MLEQGLLVTAGVAFLISVALSPLFIPFLRKLKFGQSIRDEGPKSHQKKSGTPTMGGIVIYVSMMVTSLIMAIKFNHLGAEVSLLLLVTFGYGLIGFLDDYIKVVKKRNLGLTSKQKLVGQLVIAIAFFLIGKGQAFHTYIMIPGTDVKFELGWAYFVLVLFMLIGGSNAVNLTDGLDGLLSGTAAIAFGAFSIIAVAQEQFGVAIFCMAVVGAVLGFLVFNANPAKVFMGDTGSLALGGAIAAVAILLKQELLLVIIGGVFVMETLSVIIQVISFKTTGKRVFKMSPLHHHYELCGWSEWRVVVTFWSVGFLLAVLGIYIGVWM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DSBE_ECO57
Sequence: MKRKVLLIPLIIFLAIAAALLWQLARNAEGDDPTNLESALIGKPVPKFRLESLDNPGQFYQADVLTQGKPVLLNVWATWCPTCRAEHQYLNQLSAQGIRVVGMNYKDDRQKAISWLKELGNPYALSLFDGDGMLGLDLGVYGAPETFLIDGNGIIRYRHAGDLNPRVWEEEIKPLWEKYSKEAAQ
What is the function of this protein?
Involved in disulfide bond formation.  Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme.  Possible subunit of a heme lyase (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbE, Cytochrome c biogenesis protein CcmG.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: TADA1_DANRE
Sequence: MAAHASELEIAKKNLTDAIGENVKHYWANLKLWFKQKISKEEFDLEARRLLAQDNVHVHNDFLLAILTRCQIIVSTSEGPGSLQWSGGSASKPGKPSRGKKKFPSVRQKFDHRFQPQNPLAGVPVFSPREAEEEELKLSAQTLLLPSRGQLEARMMVSAFESDLDSVAEDAVSCMLCALQVHLKDILTALVSRRKAYRLRDGHFLYAFGSDVTPRPYLKNSLPAYHSATECPPASASLPAAAPARVCPDEAEQNAALLLACSADTAAPPLQPVSVYDLLEALQVQRRVMPSHSMYALNMERILARLWHPSHEELEQDHIHRQHLALRDGLVT
What is the function of this protein?
Probably involved in transcriptional regulation.
What are the official names of this protein?
Transcriptional adapter 1, Transcriptional adapter 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the TADA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PNP_CHLAA
Sequence: MTERNIYSVSAEIAGRTLTLEAGRFAEQADGAVVARYGDTMLLATVVCAKEAREGTDFFPLTVDYEEKMYAVGKIPGNFFKREGRPTTTAILISRLTDRPLRPLFPKGFYNEVQVIITTFSIDMENDPGPLAIIAASAALCISDIPFAGPVGAVQMGHLNGQLVVNPKMNEIADSRLDLVVAGTKDAVLMVEAGAYELTEDEMLQAVIDGHAVCKQICDLQEQLVQLCGKPKRPFTPPVVDTSLEEAISAWMGDRLRKAVRSPIKQEREAQTEALKAEVIAHFTADEPEEEIANRTKEVTKAFEKLLKDEVRNAILDEGIRVDGRALDEIRPISIEVGVIPRVHGSAVFTRGQTQVLTITTLGSPGDEQKVDDLGIETSKRYIHHYNFPPFSTGEVRRIGTPRRRDIGHGALAERSLYAVLPDEKDFPYTIRLVSEVLSSNGSSSMASVCGSSLSLMDAGVPIKAPVAGVAMGLITGEDGRWRVLTDIQGLEDALGDMDFKVAGTAKGVTGLQMDIKTTGITYEIMREAFAQARAGRLFILDKMNEVISAPRPELSIYAPRIMTIQIPVDKIGALIGPGGKTIRNICETTGAQIDIEDDGRVFITTPDGAAARQAISMIEGLTREAKVGDIFLGKVVSIKPFGAFVNILPGKDGMVHVSELDEKRVENVEDVVSLGDEINVMVIDIDRTTGKISLSRRAVLTGETPEERKAAGAAPRPRPREEQRGGRDEPRSLRDELRGPRREGDRPRPRRRDD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_LACPL
Sequence: MSEIAATIATDLLTIKAVTLRPNDPFTWASGIKSPIYTDNRLTISYPAVRQHIAHGIAAIIKREYPATEVIAGVATAGIPHAAWVAELLNLPLIYVRAKPKDHGAGRQIEGVLKPGQKVVMLDDLISTGGSVLQAAKAVQAAGGDIQAVGAIFSYALDAATQNFAAASLPLFSLSNYPELIKVARQADYIDDEELASLHTWRQDPEHWGVTD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PQQC_CERS5
Sequence: MSLDLTPTLSPARPLDSADAMEDRLREIGAARYHDRHPFHHLLHGGQLTRGQVQAWALNRYYYQCSIPVKDAVVISRFRDRATRVEWRHRLEDHDGAEGTEGGIDRWLVLTDALGLDRDYVEATDGILPATRFAVDAYVHFVRDQSPLEAIASCLTELFAPHIHAERISGMLAHYDFVNPTVMAYFQRRLSQAPRDADYALRYVREHARTPQERAAVCNALIFKTQVLWTQLDALHHAYVLGHVPPGAFVPEDMR
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: CYB_DAMME
Sequence: MINIRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPTGISSDADKIPFHPYYTIKDILGILFLVFFLMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVSSILVLILMPLLHTSKQRSMMFRPFSQCLFWVLVADLLTLTWIGGQPVEYPFIIIGQLASILYFLIILVLMPIISTIENNLMKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GQ2_HHV6U
Sequence: MHFLVVYILIHFHAYRGMAALPLFSTLPKITSCCDSYVVINSSTSVSSLISTCLDGEILFQNEGQKFCRPLTDNRTIVYTMQDQVQKPLSVTWMDFNLVISDYGRDVINNLTKSAMLARKNGPRYLQMENGPRYLQMETRISDLFRHECYQDNYYVLDKKLQMFYPTTHSNELLFYPSEATLPSPWQEPPFSSPWPEPTFPSRWYWLLLNYTNY
What is the function of this protein?
Plays a role in virus entry by participating in host receptor binding at the cell surface.
What are the official names of this protein?
Glycoprotein Q2, gQ2, Glycoprotein Q-37k, gQ-37k.
What are the subcellular locations of this protein?
Virion membrane. Host endoplasmic reticulum-Golgi intermediate compartment.
Protein: LYSET_HUMAN
Sequence: MPKPPDYSELSDSLTLAVGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEISETYNRLALEHIQQHPEEPLEGTTWTHSLKAQLLSLPFWVWTVIFLVPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT
What is the function of this protein?
(Microbial infection) Essential for infection by muliple viruses, including SARS-CoV-2, that utilize activated cathepsins for entry after M6P-dependent lysosomal transport.
What are the official names of this protein?
Lysosomal enzyme trafficking factor, GNPTAB cleavage and activity factor, GCAF, Transmembrane protein 251.
What is the protein family that this protein belongs to?
Belongs to the LYSET family.