PharMolix/UniProtQA huggingface dataset:
Protein: MDH_BACAC
Sequence: MTIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANIIGTSDYADTADSDVVVITAGIARKPGMSRDDLVATNSKIMKSITRDIAKHSPNAIIVVLTNPVDAMTYSVFKEAGFPKERVIGQSGVLDTARFRTFIAQELNLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGSAYYAPAASLVEMTEAILKDQRRVLPAIAYLEGEYGYSDLYLGVPVILGGNGIEKIIELELLADEKEALDRSVESVRNVMKVLV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: YPI1_CHAGB
Sequence: MSSAAPRSQQRQQQRQPSRPAPSQTETTPSTTPQTHTQPQAILRLRGAHAPTGRSVQWRSDVVDNEGLGRKKSKVCCIYHRPRGVDESSDSSSSSSSDSSDSDSDADSDSGRASGSGKKTGDGNHKQGHAHDCDGHHSHRGSRGQGKARRKRRPSPNAYEKMPRYDKPGKDGDGDGSGGSGEGKGKGVPGQGPQGA
What is the function of this protein?
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
What are the official names of this protein?
Type 1 phosphatases regulator YPI1.
What is the protein family that this protein belongs to?
Belongs to the YPI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IF3_SYNPW
Sequence: MPPRPRFDRRAPVRELPNINERINYPQLRVVDADGTQLGVIDREKALEVAQERELDLVLVSEKADPPVCRIMDYGKYKFEQEKKAKEAKKKSHQTEVKEVKMRYKIDQHDYDVRIGQAQRFLKAGDKVKCTVIFRGREIQHTALAETLLRRMAKDLEEPAEIQQPPKREGRNMIMFLTPRKTPLVKKDDKEEPATRAVRTITAPPRPTSARLASKPAGNG
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_XANC5
Sequence: MIYLHAIDPIAFSLGPVQVHWYGLMYLAAFFSAWALGRSRILRGRLPGVDMDGFSDLLFYGMLGVVLGGRIGYMLFYAFETFLANPLILFKVWEGGMSFHGGLLGVLIACWLWARKHRLHFFDVMDFVAPLVPLGLGFGRLGNFVGGELWGKFTQAGWGVIFPHAPELADRLPAQIQAQYAAGALNQFARHPSQLYEAALEGVVMFVVLWTFSMKPRARYAVSGLFALLYGVFRFIVEFVRVPDAPIGYLAFNWLTMGQILSLPLIAVGLVLLAMSRRAPVLQPVLPAPAGVEAAK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSRC2_RAT
Sequence: MIRTNFLLKQARRHESKDKSSKRHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRDRKKSRSRSRDRKRRIRTRSRSRSRHRHRTRSRSRSRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEMAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV
What are the official names of this protein?
Arginine/serine-rich coiled-coil protein 2.
What is the protein family that this protein belongs to?
Belongs to the RSRC2 family.
Protein: Y1215_CAUVC
Sequence: MVATLFIDADACPVKDEAYKVAARHGYKTFVVSNSWIRVPATPVIEQIVVDAGPDVADDWIAERCGPGDVVVTNDIPLADRVLKAGGAAVAPNGRVFSHDMIGSALASRSIGEHLRSMGEVTKGPAAFANADRSRFLQALDQLVVKAKRAAPR
What are the official names of this protein?
UPF0178 protein CC_1215.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: TIM9_ASPFU
Sequence: MDGLTAAEQRELASRMERKQLKEFMTMYSKLVQRCFDNCVNDFTTKSLISREEGCIMRCVDKYMKASSRLNERFQEQNAAMMQGGQLPGR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: GCST_CLOBJ
Sequence: MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTNDINVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQKIVDVDLQEIKFFKLKRDVLVDGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASLLLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDKRFYTKKTKTK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: AMPG_STRLI
Sequence: LQMLHAWTNSALVHYAAPDWRETGGRLLGEGALRELRDGRRAASSSWPGRGSSRRWRPGRRTGAAARGCWRAP
What is the function of this protein?
Hydrolyzes preferentially the N-terminal glycine and can also hydrolyze other amino acids which are used by PepN but is unable to hydrolyze basic amino acids.
What are the official names of this protein?
Aminopeptidase G.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_MYCTU
Sequence: MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAFVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7S_CLOP1
Sequence: MARKETNYESMVSELNEIVKQLENGDLTLEESIKSYENGVKIVNKLYKKLSTLEGKIKVVEDEKEEDFGGYSNEY
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_ACTP7
Sequence: MPKIKTVRGAAKRFKKTASGGFKRKQSHLRHILTKKTTKRKRHLRHKSMVAKADQVLVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PLB1_SCHPO
Sequence: MLFRGLSLWMLFLASCLSALALPAAEDDGSVKVFKRAKKHSTKQEGPSYAPYYVDCPSDNIVESLSSNEIPSAESEYLSTRSTITNTAMKDFLRNANLPGLNADTLSGSEGPSIGIALSGGGLRAMILGSGALSAMDARHDNHTVLTGLLQASDYLVGTDGSAWTVGGIALNNFSTINDFSKLWAFNHPLMYPKSAIVFNAHFYSSIMNEVAEKANAGFNISLSDYWGRVISRTLGDTTYGFPNVSLSSITSQEWYRNANFPYPIITFATQNYGEDISNVNTTFFEASPNVFGTFDHGINSFIPTEYLGTTLNNGASSNGSCVINYDNFGFMMGASSTYFNKIMRNFNDSSTKNGRIIQQYLKGNFSENGQQIISIPNPFQGVESANSDAANNLGSSSSLNLVDTFLTGEKIPLWPLLQKGRDVDVIVAVDNGDDSEWLWPNGNSLVQTYERVVAAQAAGNTNVKGFPYVPSQQSFVSLHFNDRPVFFGCDGRNTTAGNHTVTRDTPPLVIYLPNVPYNYFTNISTDRTYYTEDMIQQLLTNGLISSTVDNDTYFGQCFACAVVKRTLERNNITASPECQQCYYNYCWSGLYDDSAANDDIVYNPTCRLGEGI
What is the function of this protein?
Catalyzes the release of fatty acids from lysophospholipids.  Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation.
What are the official names of this protein?
Lysophospholipase 1, Phospholipase B 1.
What is the protein family that this protein belongs to?
Belongs to the lysophospholipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL1_METST
Sequence: MTQVIEEAVKKVLEESKPRNFTQSIDVVITINDLDINKPENRLDEEVLLPNGRGKDVKIAFIAEGELAYQAEQAGADLVINKEKLEELGKNRPEAKKLANSYDFFVAQTDLMPTVGRFLGPVLGPRKKMPKPIPASANPETILGRLRSTIKIRVKDQPIIQSIVGSEDMTEAQVAENIDAIMDVLDRNLEKGSKQIKAMYLKTTMGPVTRVI
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: Y2694_BACVZ
Sequence: MKMTSRKLADLLKQRLQHENRSFFFDREKDTLRVEDQTTKKGITLELPPIIAKWETKKEEAIDEIVYYVSEAMEAMEGSGQEMSGKEAGIYPVIRSTSFPDQTSDGIPLVYDDHTAETRIYYALDLGKTYRLIDSRMLEKENWTKERIRETASFNLRSLPSVVKQDTVADNYFYFFRANDGYDASRILNDSILHEYKQAAEGELAISVPHQDVLILADIRNESGYDILGQMSMSFFASGTVPITALSFLYNEGRLEPVFIMAKSRPKKD
What are the official names of this protein?
UPF0354 protein RBAM_026940.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: MUB1_ASPNC
Sequence: MREVNFSIPNVNKASVNITTTLYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTVDGGIERLVCILKEGRSRDLMEMWKWSLAFQCVVNIGVRGSESVRTRVVEADMVPVIATILDNYIKVVEKARARADSESQRHSSRHHSKAAPISSDAPSRPVYVDQSTNTEQRPSRRQAPPPHIEIPPFYQDSHASDSNAMDITSSPRVPVTSPPERSTFGQDAHNLRSNDTRYAHAAHRYRVMQPLATALPPMDAADGFGLRPVRDTERLPSMLPGFQNGLASQPDSPTTPSGPAQLRSNTQVAPARPRPTLRQQQSASGESDDGNGEGSTLGDDPGSGETAEPIVGIQNRMEIDDDGDRQTVLEGVSNTHDLTVNDTSESQEAETFNITHRSTVDGSMINNDATRTNGALGLSPTQAPNTANSPAVVPSPYSLYVRDRSTTAVQGVLTTMPKDEDVLMSLQLLAYVSKYCNLRSYFQHSHLVPKLKVDRELQMLEDGVSPIEPAEEEDEYLLPDDVNIFPLVEKFTVRHHSKDMQYWACVVMRNLCRKDESRGGIRQCAYYKCGKWEEFQRQFAKCRRCRRTKYCSKDCQKAAWVYHRHWCHTTP
What is the function of this protein?
Involved in determination of the onset of polarized growth and morphogenesis.  Plays a role in the regulation of branching in hyphae and spore formation (By similarity).
What are the official names of this protein?
MYND-type zinc finger protein samB, Suppressor of anucleate metulae protein B.
What is the protein family that this protein belongs to?
Belongs to the MUB1/samB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRML_PHOAA
Sequence: MLNIVLFEPEIPPNTGNIIRLCANTGFQLHLIQPLGFTWDDKRLRRAGLDYHEFANIKQHHDYHSFLENEGVTGESFARLFALTTKGTPAHSAVSYQAGDYLMFGPETRGLPSYVLDNMPPQQKIRIPMLADSRSMNLSNSVAVVVFEAWRQLGYSGALLKE
What is the function of this protein?
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA).  Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
What are the official names of this protein?
tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSPB_DICDI
Sequence: MVDTTNLIPNTPRYLKVPLIAFNTILWVLGLVLVIIGSIGVSFFSNFKDFTKVSKASAALSNLTTGAPAGVLVIGIFFVILTVIGCFVAGKEKLVGLVIYTMLMLIILVALIGVGGKALTLHNDDVVKQIGNAWEDVSNGPKNSTILKLENFLKCCYWNSTSSRNPLLCPKDSKGIPKYTDTCDSVISSKISSNLYLVGAAAVSIGVIEFICMLFALFLIIRICRAPRTKSYDYQ
What are the official names of this protein?
Probable tetraspanin tspB.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMG_WOLWR
Sequence: MHKYDVVVVGGGHAGCEAAAAAARLGTNTLLITHKISTIGEMSCNPAIGGVAKGVVVREVDALDGIMGRAIDRASIHSVILNSSRGAAVWGPRAQADRKLYKQAIQEIILNYNNLTVKEESVDDFLIESNNNGELCIKAVITSSGEHILTGKVVLTTGTFLQGVIHIGEQTTPSGRMGDKPAVELANTLNKYDFRLGRLRTGTPPRLDRGTINWSILQEQVGDNPPVPFSYLTEKINQPQVSCFITHTNENTHKIIRENLHRSASSYLSDVVAPRYCPSIEVKVKKFAEKSSHQIFLEPEGLDDDTVYPNGISNSLPIEVQREMIKSIKGLENAEILRPGYAVEYDYIDPRELFHTLETKKVKGLYFAGQINGTTGYEEAAGQGIIAGINAALSAFEKKESFVLHRTDSYIGVMIDDLVTKGVIEPYRLFTSRAEYRLAIRSDNADRRLTQKGYDISLVSHERYSVLQNKLESIKQLEEKLGSLTITPEQLRSYGIKISYDGIRKTALDLLSYPNIDWNKLQEIWPELSSVTRWNDKMGHTKADNRAKNEICEAVEIEAKYKPYLIRQEADMKFLREEINTQIPIDFNYSQVKGLSSEVIEKLQTIKPATIGIAKQIQGITPAAIVSILVYLRNRKTKVAANFV
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_PSEFS
Sequence: MLQPKRTKFRKQMTGHNRGLAQRGSKVSFGEFALKSVARGRLTARQIESARRALTRHVKRGGKIWIRVFPDKPISKKPLEVRMGKGKGNVEYWVAQIQPGKVLYEIEGVSEELAREAFALAAAKLPLATSFVKRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ORF5A_PRRSR
Sequence: MFKYVGEMLDRGLLLAIAFFVVYRAVLFCCARQRQQRQQLPSTADLQLDAM
What is the function of this protein?
Minor virion component that plays an essential role in virus infectivity.
What are the official names of this protein?
Structural protein ORF5a.
What is the protein family that this protein belongs to?
Belongs to the arteriviridae ORF5a protein family.
What are the subcellular locations of this protein?
Virion. Host cell membrane.
Protein: COXM2_HUMAN
Sequence: MHPDLSPHLHTEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKLFNPPEESEK
What is the function of this protein?
May be involved in cytochrome c oxidase biogenesis.
What are the official names of this protein?
COX assembly mitochondrial protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the CMC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RSMA_LEUCK
Sequence: MADIIDIANPTRTQAILNQYGLHAKKKFGQNFLTDLNVLHGIVDVAGITSEDYVIEIGPGIGALTEQLARSAKKVVAFEIDPHMVAVLAETLLPYDNVKVIENDILKVNLAHVIATEFGEGAHVKIVANLPYYITTPILMQLLRAKISWDNIVVMMQREVADRLNAEIGTKAYGVLTLTIQYYAQAQLAIKVPASAFNPSPNVDSAVVMLTPIVPETVVDNPDKLFSVVKGSFAHRRKSLWNNMLQMFGKQEDVKQRIQDALDSVNIASSIRAERLSLNQLTALYEALKLQGLIK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OHRB_BACSU
Sequence: MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNPEQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKDLDREKAQELVNAAHEFCPYSKATRGNVDVKLELK
What is the function of this protein?
Involved in organic hydroperoxide resistance.
What are the official names of this protein?
Organic hydroperoxide resistance protein OhrB, General stress protein 17o, Gsp17o.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: CLPB_NEIMB
Sequence: MRYDKLTAKFQQALAEAQSLALAADGSYLEAGFVLKALLDDQNSGAAALLAHAGVNVPQVKQRLQQHLNSLPKVSGQGGDILPSRELQAVLNLMDKAATKRSDAYIASELFLLALVQQNDATGKILKEAGATEQNINAAIDAVRGGQNVNDANAEDQRDALKKYTLDLTQRARDGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLRNKRLLVLDLAALIAGAKYRGEFEERLKGVLNDLAKDDGNTLIFIDEIHTLVGAGKTDGAMDAGNMLKPALARGELHCIGATTLDEYRQYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQERYEIHHGIDITDPAIVAAAELSDRYITDRFLPDKAIDLIDEAASRVKMEKETKPEAMDKIDRRLIQLRMEKAHVEKEKDDASKKRLELIDEEINGLQKEYADLDEIWKAEKAISDGAANIKKQIDEVKIKIEQAKRQGDLALASKLMYEDLEHLEKQRAAAERADTDSTKPANKLLRNNVGAEEIAEVVSRMTGIPVSKMMEGERDKLLKMEEVLHRRVVGQDEAVRAVSDAIRRSRSGLADPNKPYGSFLFLGPTGVGKTELCKALAGFLFDSEDHLIRIDMSEYMEKHAVARLIGAPPGYVGYEEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMTSNIGSQHIQQMGIQDYEAVKEVVMEDVKEHFRPEMINRIDEVVVFHGLDQDNIRNIAKIQLKGLEKRLEKQNLRLAVSDAALDIIAKAGFDPIYGARPLKRAIQSEIENPLAKALLAGNYAPESEIRVEADGDRLKFA
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_LACLA
Sequence: MTIIEGNLRTENAKYGIVVAQFNEFINAKLLSGALDALKRHGVQEEEIDIAWVPGAFEIPIIAQKMATSNKYEAIICLGTVIRGSTSHYDFVCNEVSKGIAHVSLNSNIPVMFGVLTTENIEQAIERAGTKAGNKGFEVAVGAIEMVDLMRKIG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: FER_MOUSE
Sequence: MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAYTLQNLCNQVDKESTVQVNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYVGIHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDDYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELEKRIEESFETCEKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKALLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQVCDVISVGERPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLVRFSLDVAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTIMMKCWDYKPENRPKFNDLHKELTVIKKMIT
What is the function of this protein?
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis.  Acts downstream of EGFR, KIT, PDGFRA and PDGFRB.  Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation.  May play a role in the regulation of the mitotic cell cycle.  Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.  Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Plays a role in the regulation of mast cell degranulation.  Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS).  Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11.  May phosphorylate JUP and PTPN1.  Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation.  According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation.  Phosphorylates TMF1.  Isoform 3 lacks kinase activity.
What are the official names of this protein?
Tyrosine-protein kinase Fer, Proto-oncogene c-Fer, p94-Fer.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts (By similarity). Not detected in the nucleus, but detected in the nuclear area surrounding the chromosomes after breakdown of the nuclear envelope during mitosis (PubMed:11339827). SUBCELLULAR LOCATION: [Isoform 4]: Nucleus.
Protein: DCUP_DESPS
Sequence: MNDTFLKACRGEKTDYTPIWMMRQAGRYLPAYQKIRGKVSFLELCKNPALCVEVTLQPVDLLGMDAAILFSDILILMEAMGAKLEFNEGCGPVFPNPIKDQTALDALIIPDADDATGFVMETIRLLRGELQVPLIGFAGAPFTCATYLIEGGSSKVFWETKKMMFTQPELFHGIMEKITQATILYLQAQARAGAQALQIFDSWAGVLAPCDFEVFALPYVRRIIASLQQFDLPIIYFANNGSTLLEMSASSGASVLGLDWRINIGDAGKRVPGIALQGNIDPFALLLPKDKLRKRIGTILEDAKEVKGHIFNLGHGIHQFTPPEQARIAVDAVHELSCK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSH1_KLEP7
Sequence: MIPDVSQALAWLEKHPQALQGIQRGLERETLRVNADGTLATTGHPPALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDVHRYTARQLGDERMWPLSMPCYIAPGQDIELAQYGTSNVGRLKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGVEDAESGKEAISAGYFRSIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEETGNGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYAKIGLQKDGKYLQINSNILQIENELYAPIRPKRVTRRGETPSDALLRGGIEYIEVRSLDINPFSPIGVDAQQVRFLDLFMVWCALADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCESAQFPLAQVGKDLFRDLRRVAQTLDSIHGGQAYQQVCDELLACFDDPELTFSARILRSMIEEGIGGTGRALADRYRTQLREEPLEILSEDDFIAERDASVARQKKVEAEDSEPFEALLARHA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: LFTR_SHEB8
Sequence: MKSLSFLNHEFEAFPSPELALNDPNGLLAIGGDLRPERLLSAYYNGIFPWFNSDDPILWWSPDPRAVFIPGEVHISTSLRKYLKKQPWRITINHAFTDVMAGCAQPREKQSGTWITQEIQMAYRELHHTGHAHSIEVWEGERLIGGLYGLAIGQVFCGESMFHRKTNASKAAVAALQQHLLKMGFKLIDAQVMNPHLESLGAKGIKRIDFITLLRELRNNPVDPATWTTKEVILELE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.