PharMolix/UniProtQA huggingface dataset:
Protein: TRAF_RHIRD
Sequence: MRRREVLLFLTGSRVRHVRTGVDSLIGGYRLNLTPSEPLGLWRIEALHRPVSIGDLVFFCPPMTAVFDEARRRGYVRRGLCAGGVAPLIKTVAALAAQNVEITDHIVIDGRSLPSSVVRKTDGEGRVLLPDPGGVVPPHHLFLHSSFASSYDSRYFGPVPDSGLLGLARPVFTFDP
What is the function of this protein?
Involved in conjugal transfer of the plasmid.
What are the official names of this protein?
Conjugal transfer protein TraF.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26C family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYN_YERPE
Sequence: MSVVPVVDVLQGRAAVGSEVTVRGWVRTRRDSKAGISFVAVYDGSCFDPLQAVVNNTLPNYQDEVLHLTTGCSVEVTGTVVASPGEGQSFEIQATAINVVGWVDDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQAIHRFFDENGYFWVSTPLITASDTEGAGEMFRVSTLDLENLPRTDTGAVDFSEDFFGKEAFLTVSGQLNGETYACALSKVYTFGPTFRAENSNTSRHLAEFWMVEPEVAFASLDDVAGLAEKMLKYVFQAVLNERADDMKFFAERVDKDAVDRLQRFVTSDFAQVDYTDAIEILLASGQKFENDVSWGIDLSSEHERYLAEKHFKAPVVVKNYPKDIKAFYMRMNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDARLAEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLISYVTGVQNVRDVIPFPRTPRNASF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPC2_ARATH
Sequence: MATSKLQALWNHPAGPKTIHFWAPTFKWGISIANIADFQKPPENISYLQQIAVTCTGMIWCRCSTIITPKNWNLFSVNVAMAATGIYQLTRKIKYDYVSEAEAAVEIEG
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: G6PI_ENDTX
Sequence: MSKFGLKNTPQWQGLEKNYREIKKIHLRELFKDENRFNKFSIRDNDLGITFDYSKNIINSDTFKLLIEFVKAAKVTEYAKKMFSGEKINWTEKRAVLHTALRNRSNMPIYVNGKDVMPEIKAVLKKMENFSNDLRSGKWVGATGKKVTDVVNIGIGGSDLGPKMVCESLKYYADGPNVYFVSNIDGADIYEVLKKLNPGTTLFIVASKTFTTLETITNALTARKWLTDKLGDKAVANHFVALSTNVKKVKEFGIDENNMFEFWSFVGGRYSLWSAIGLPIACYVGFDKFIELLDGAYYIDQHFLNAPYEKNIPVIMAALGVWYNNFWGASSHAVLPYSQYLNKFPAYLQQGDMESNGKTINFEGRRVDYGTGPIIWGESGTNGQHSFYQLIHQGTKFIPCDFIGFVNPPEKIGDHHEKLMANYFAQTEALAFGLTKEEVAKNLKKAGISPADIKILTPHKIFEGNKPTNSILFDELTPRTLGALIALYEHKIFTQGIMWRINSFDQWGVELGKVLANVILPELKGQTDNKHDNSTKNLIKIFNSNKK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_CHLPD
Sequence: MKTGIKKVKLHVKKNDMVVVISGNDKGKTGKILRVFPVKGRVIVEGVNIRKRHMKPTQGNPQGSIIEREFAIHASNVKKS
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CMOB_SHEDO
Sequence: MISFSSFYQQIADSTLQHWLEDLPAILGKWQREHKHGNLPKWEKVLNKLNYAEPDSVDFVDSVTIGSGSQLSAGQQQKLENLLRLFQPWRKGPFNVHGIDIDTEWRSDWKWQRVRQHISPLAKRTVLDVGCGSGYHMWRMLGDGAARVVGIDPSPLFLCQFEAIKRLAGNQHPVHLLPLGIEELPPLDAFDTVFSMGVLYHRRSPIDHLYQLRDQLRMGGELVLETLVIDGDENTVLVPEDRYGKMNNVWFLPSVAALMLWLKKCDFTNIRCVDVDTTSLAEQRSTTWMPNESLVDYLDPKDINLTIEGYPAPKRATIIATKNQPNFDLI
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: SORC3_MOUSE
Sequence: MEAAGTERPAGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPGRLVSPASRPPVLPPLLPRAAENRWPEELASARRAAAPRRRSRLEPLSQASRGEIRTEAAGMSPEGARWVPGIPSPSQAGSARRTRRAQPPSPLERGDSWATALADGAKGSRPHTKGSREEVRATRTGGASTEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSVLISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVSGLDKEADLVHMEVRTADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKDTAPGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGVETHIMTVFGHFSLRSEWQLVKVDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRKPGAQCALGREYSGSVVSEPCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHVHLRVPFVAIRNKDVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTNTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRQDIGNVIKRALIKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGSIATIASSESTKEIPNCTSV
What are the official names of this protein?
VPS10 domain-containing receptor SorCS3.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family. SORCS subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DB134_PANTR
Sequence: MKPLLVVFVFLFLWDPVLAEMHKKCYKNGICRLECYESEMLVAYCMFQLECCVKGNPAP
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 134, Defensin, beta 134.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YHFG_ECO57
Sequence: MKKLTDKQKSRLWELQRNRNFQASRRLEGVEMPLVTLTAAEALARLEELRSHYER
What are the official names of this protein?
Uncharacterized protein YhfG.
Protein: MTPS2_SANAL
Sequence: MDAFATSPTSALIKAVNCIAHVTPMAGEDSSENRRASNYKPSSWDYEFLQSLATSHNTAQEKHMKMAEKLKEEVKSMIKGQMEPVAKLELINIVQRLGLKYRFESEIKEELLSLYKDGTDAWWVDNLHATALRFRLLRENGIFVPQDVFETFKDKSGKFKSQLCKDVRGLLSLYEASYLGWEGEDLLDEAKKFSTTNLNNVKESISSNTLGRLVKHALNLPLHWSAARYEARWFIDEYEKEENVNPNLLKYAKFDFNIVQSIHQRELGNLARWWVETGLDKLSFVRNTLMQNFMWGCAMVFEPQYGKVRDAAVKQASLIAMVDDVYDVYGSLEELEIFTDIVDRWDITGIDKLPRNISMILLTMFNTANQIGYDLLRDRGFNGIPHIAQAWATLCKKYLKEAKWYHSGYKPTLEEYLENGLVSISFVLSLVTAYLQTETLENLTYESAAYVNSVPPLVRYSGLLNRLYNDLGTSSAEIARGDTLKSIQCYMTQTGATEEAAREHIKGLVHEAWKGMNKCLFEQTPFAEPFVGFNVNTVRGSQFFYQHGDGYAVTESWTKDLSLSVLIHPIPLNEED
What is the function of this protein?
Monoterpene synthase which catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (R)-alpha-terpineol and (4S)-limonene, as well as small quantities of linalool, myrcene, (-)-alpha-pinene, (+)-sabinene and geraniol (PubMed:18541135).  To a lower extent, catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to beta-bisabolene (PubMed:18541135).
What are the official names of this protein?
(+)-alpha-terpineol synthase, (-)-limonene synthase, Beta-bisabolene synthase, Monoterpene synthase 1, SaMonoTPS1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
Protein: ENGB_COXB1
Sequence: MTEFESAPAYQEAKYLTSAAEFDQLPPDQGAEIAFIGRSNAGKSSALNIITGIKGLARTSKTPGRTQMINFFALNEHERLVDLPGYGYAKVPRMVQKRWEELVDSYLKKRRCLKGLVVVMDIRHPLKEVDEDVIEWAVNYDIPIHILLTKSDKLSQNAAKKTLGEVQTAISAYGEKLTLQLFSSHDRTGLDEVKAVLSQWFSSEP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MUTL_BACC0
Sequence: MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPEVTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEETLQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKEPSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQSLVREEQSWQPSTKPIIEEPIQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYMIDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: PSUG_CLOBL
Sequence: MLEKYLEISKEVSEALKENKPVVALESTIISHGMPYPKNAETALNVEKIIRDKGAIPATIAILNGKLKVGLTKDEIEYLGKKGKEVVKTSRRDIPFILAKKLDGATTVASTMIVANLAGIKVFGTGGIGGVHRGAQESFDISADLQELANTNVAVVCAGAKSILDIGLTLEYLETQGVPVVGFGTEELPAFYTRKSGFKVDYRVDTAKELAEALKAKWDLGLKGGMVVGNPIPEEYQMDYDTITKAINDAVKEAEEKGIKGKESTPFLLAKVKDITKGKSLEANIQLVYNNVAVASDLAIELSKLNK
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: TRMN6_PARD8
Sequence: MANPYFQFKKFTVWHDKCAMKVGTDGVLLGAWASTERCQRILDVGTGTGLIALMLAQRSTAILDAIDIDSDACLQAQENIAKSPFANRIQVYQTSLSEYMPDENIKYDLIVSNPPYFIDSLKCPDTKRNLARHTDTLSLPDLLRDSRKLLAPEGNIALVLPFEQRESLIDIAREESLSPSREAHVSPIPDAPPKRLLIELSATPVAKPKSSHLTLEIERHRYSEEFTAIAKDFYLKM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOL_HBVF3
Sequence: MPLSYPHFRKLLLLDDEAGPLEEELPRLADEGLNRRVAEDLNLQLPNVSIPWTHKVGNFTGLYSSTVPTFNPDWLTPSFPDIHLHQDLIHKCEQFVGPLTKNELRRLKLVMPSRFFPKVTKYFPMEKGIKPYYPDNVVNHYFKTRHYLHTLWKAGILYKRESTRSASFCGSPYSWEQELQHGSTSINDSKGHGTESLCTQSSGILSRPSAGSSIQGKFQQSRLGLQQKQGQLANGKQGRSGRIRSWVHTPTRWPVGVESTGTGCAYNIASRSASCFHQSAVREKTNPSLSTSKRHSSTGHAVELHSVPPGSVRSEGKGSVFSCWWLQFRDTEPCSDYCLSHIINLLEDWGPCYEHGQHHIRTPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGNTRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSCGLSRYVARLSSTSRIHDHQHGTMQNLHNSCSRNLYVSLLLLFQTLGRKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDLVLGAKSVQHLESLYTAVTNFLLSVGIHLNTSKTKRWGYTLNFMGYVIGSWGSLPQDHIVQKLKDCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACITAKQAFVFSPTYKAFLCQQYMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLRLPFQPTTGRTSLYAASPSVPSHLPDRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: SYGA_STRU0
Sequence: MSKKLTFQEIILTLQQFWNDKGCMLMQAYDNEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEKLGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATQPVTSEVTYGLERLASYIQEVDSVYDIEWSPGVKYGEIFLQPEYEHSKYSFEISDQVMLLENFEKFEKEASRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARLVAKTFVAERRKLGYPLLDEATRVELLKEETE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_RAT
Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c, somatic.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: TOP1_ECOLI
Sequence: MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: STE11_SCHPO
Sequence: MSASLTAEQKDQKSSVKRPLNSFMLYRRDRQAEIPTSNHQSISRIIGQLWRNESAQVKKYYSDLSALERQKHMLENPEYKYTPKKRSTVRRRHKKVSPSSGSFVASDYVVLQQIAQSSKTLKQTEPEKPVNEEETLAALLAPALSYPKSGKSNLIETSELSCLSSSPMIRSHTIPSLSFTDQVSTTISTLDKSEQAPSSLGIYYRSPSSGSPIGRTKSVCLANKARIVPKRSMSSDGCVDKSYQMSKTPSLEANLPQNSSNCSARRVPKFDSKGTVSEQSNSDSPELSADKVLSHCSPIDARPSTPSCPNASISPKTPNTGDHYGFDGAEYLGTPLSVGSTTAYLYGQETELLSTPYCHTSYPAMSRLNSSSGYTCVSSSSVTNSGHTENNTWRSDEQSKGFVDINSFSQSLFSNGNYEFAAHSQELDDLFSQITDFTSTDPIASSLKDANSLGPSLLEPWLPNSNLF
What is the function of this protein?
Key transcription factor for sexual development.  Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes.  Binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'.
What are the official names of this protein?
Transcription factor ste11.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Accumulates in the nucleus under conditions of nitrogen starvation and in the presence of mating pheromones.
Protein: RUVA_RHIWR
Sequence: MIARLRGVLAETSADHAVLDVGGVGYLVWCSARTLSAIGETGGDVLLFTEMQVREDAITLYGFGSAGERDSFRLLTSVQGVGGRVALAILSVLDAGELSRAVAGGDKAMIARANGVGPKLAMRIVNELKDKMGGVALGPGLGAAPAAKGGVSTDALSALANLGFRPAEASAAVGAAIEELGDGATLDAVVRLALRKAAK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CAZA2_PLEMO
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRSCEVENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: RS7_PYRIL
Sequence: MSTGIFGEQLPKHTKIEYIGDVPIIEECPRDIKTLNGEPVLLFGKWSFENVVVKDPGLRRYICLKPVLLPHTEGRYQKHRFGKARIPIVERLINLMMRPGRNTGKKHKAYNIVKRAFDIIYYKTGQNPIQVLVDAIINVAPREEVTRIIMGGIAYTVSVDVSPQRRLDLALRWITEGARTCSFNNPKPIEECLADEIIAAASNDPRSYAVRKREELERIAAASR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: THIM1_CLOB6
Sequence: MENKNVIQKMREKTPLIHCITNYVTINDCANILLSFGASPAMCEAYDEVYDFVSISSALYINLGTLTKEQETAAVLASISAKNHNVPVVIDPVGCPAIKRKVEVINRMAEVGRIDIIKGNIGEIKFLAGMDSETRGVDSLDNGENALDACTQLAKKYNCIVAATGEKDFVSDGKRGSVIKNGTEMLTKVTGAGCMLGALCAATCANFEDKLVSTTAAILSMNIAGEKAYEKAQLPGSFRIALIDNIYMISDEEIWERGNVEWK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 1, 4-methyl-5-beta-hydroxyethylthiazole kinase 1, TH kinase 1, Thz kinase 1.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: NUOK_ECOSE
Sequence: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_BORBR
Sequence: MKPSMRSRLEQLAHRLIEVDALLAEPETAADMDRFRKLSRERAELEPVVEAFNAFLGVEADVATAQEMLSDPDMKAMAEDEIKTGRARIEEMEAALQLLLLPRDPDDGRSLFLEIRAGTGGDESALFSGDLLRMYTRYAETRGWRVEIMSESESELGGYKEVIARIDGDGAYGRLKFESGAHRVQRVPATEAQGRIHTSACTVAVMPEADAMSDIVINPSDLRIDTFRASGAGGQHINKTDSAVRITHVPTGLVVECQDDRSQHRNKDKAMQVLAARLKDKEMRERQSKEAAERKSLIGSGDRSERIRTYNYPQGRVTDHRINLTLYKLQQIMEGDLDELTGALLAEHQAEQLAALGHDL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABV_SERP5
Sequence: MIIKPKIRGFICTTAHPAGCEANVREQIAYVKSRGELKNGPKKVLVIGASTGYGLASRINAAFGSGAATIGVFFEKPGSEAKTGSAGWYNSAGFDKAAKEEGLYAKSVNGDAFSNECRQTVIDLIKQDLGQIDMVVYSLASPVRKMPETGEVVRSALKPIGEPYKSVALDTNKDVLVEAVVEPANEQEIADTVKVMGGQDWQLWMDALEEAGVLADNVQAVAYSYIGTDLTWPIYWHGTLGKAKEDLDRAALAIDQKLKAKGGAAYVAVLKSVVTQASSAIPVMPLYISIVFKIMKAQGIHEGCIEQIQRLFATKLYSGTAPDTDEKHRLRLDDWELRDDVQNTCREIWAQINDNNINELTDYLGYKAEFLRLFGFGLQGVDYEADLSGEVKFDVVELV
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: AROE_MOOTA
Sequence: MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKALGFRGANVTVPHKEAIIPYLDAVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAGFDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPERATELAGALAGAGLPAPVVYRLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAGARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.