PharMolix/UniProtQA huggingface dataset:
Protein: ANGT_COTJA
Sequence: DRVYVHPFSL
What is the function of this protein?
In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from angiotensinogen.  ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps regulate volume and mineral balance of body fluids.
What are the official names of this protein?
Angiotensinogen, Serpin A8.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDAD_CHLTE
Sequence: MSFVPTKVFFTKGVGRHKEYLSSFELALRDAKIEKCNLVTVSSIFPPKCERISVEEGLKHLKPGQITFAVMARNSTNENNRLISASVGVALPADESQYGYLSEHHPYGETAEQSGEYAEDLAATMLATTLGIEFDPNKDWDEREGIYKMSGKIVNSFNITESAEGETGMWTTVISCAVLLP
What are the official names of this protein?
Probable pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: TA15B_ARATH
Sequence: MAGMYNQDGGGGAPIPSYGGDGYGGGGGYGGGDAGYGGRGASGGGSYGGRGGYGGGGGRGNRGGGGGGYQGGDRGGRGSGGGGRDGDWRCPNPSCGNVNFARRVECNKCGALAPSGTSSGANDRGGGGYSRGGGDSDRGGGRGGRNDSGRSYESSRYDGGSRSGGSYGSGSQRENGSYGQAPPPAAAIPSYDGSGSYPPPTGYGMEAVPPPTSYSGGPPSYGGPRGGYGSDAPSTGGRGGRSGGYDGGSAPRRQEASYEDAATEKVKQCDADCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGRIKQKRGYKDQWPYNIKIYTDEKGNYKGDACLAYEDPSAAHSAGGFFNNYEMRGNKISVTMAEKSAPRAPTFDQRGGGRGGGGGGYGGGGGDRRRDNYSSGPDRNHHGGNRSRPY
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 15b, TBP-associated factor 15b, AtTAF15b.
What is the protein family that this protein belongs to?
Belongs to the TAF15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOI_DEIDV
Sequence: MGVLEIAKGMGLTLGKLFQKPVTVSYPEERATLKPRFRGRHVLTRHPGTGLEKCIGCSLCAAACPAYAIYVEAGENDPHDPVSPGERYAKVYEINMLRCIFCGMCEEACPTGAVVLGNEFEMADYRYNDIIYGKEDMLVGVEGSRAQRRDAANAGKPVRVGFRVDGGARDELEGVTYPQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y187_ATV
Sequence: MSTTFDKDQENEQQQQDAQAIWKKILSPGARITKDDVDFAIDNLESAPDVPYEFMYATFSPNAKIYQPTAIAVSGVGGIIGALLALKRALQYGGPKYYVTTEEVIKATDQKSPLYLANYALNRLLKAYPAQVVVIKPDDFDKIKTLLSSGGVYISGLPYETLIPISQLSGFGRIWHYSPIQKKFFVF
What are the official names of this protein?
Structural protein ORF187.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Virion.
Protein: HEM3_SYNAS
Sequence: MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARIGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLPVAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEHLEDGQP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: COL80_CAEEL
Sequence: MSTTFLSVMAGLSGIVVFGALISVFHIYTDINSFVDEAHRELGAFRGVANDAWNSMVNHDDSARVARSVFVRRQKKQSQCNCGPQASNCPAGPPGPPGASGDRGLDGQPGPAGKPGQPGVAGPAHHQQQECIKCPQGAPGPAGAPGNPGPQGPNGNPGAPAHGGGQGPPGPPGPAGDAGSPGQAGAPGNPGRPGQSGQRSRGLPGPSGRPGPQGPPGAPGQPGSGSTPGPAGPPGPPGPNGQPGHPGQDGQPGAPGNDGAPGSDAAYCPCPARSAAVFRHRNVAVNRHRAVAKKRVVAKKRVVARKRVVAARRHVQA
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
What are the official names of this protein?
Putative cuticle collagen 80.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: RS10_ECOLU
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ACKR3_CANLF
Sequence: MDLHLFDYAEPGNFSDISWPCNSSDCIVVDTVLCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVVTIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLTCMSVDRYLSITYFASTSSRRKKVVRRAVCVLVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSVKEWLISMELVSVVLGFAIPFCVIAVFYCLLARAISASSDQEKQSSRKIIFSYVVVFLVCWLPYHVVVLLDIFSILHYIPFTCQLENFLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNAK
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1.  Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway.  Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness.  In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis.  Promotes cell growth and survival.  Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration.  Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12.  Required for heart valve development.  Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels.
What are the official names of this protein?
Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CXC-R7, CXCR-7, Chemokine orphan receptor 1, G-protein coupled receptor RDC1, RDC-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Protein: MUTL_THEPX
Sequence: MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDDGCGMNEIDAILAFERHATSKIKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALFGTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKFLKRPSTESMYIIDVVTKLCLSHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKNSLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIHPSKLEIKFSDERRIFEAVYKTIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYLTSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLDNHLAVYEEYEHEKEEINKNDLAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPIVVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLKDKELINKISLKEENIIMMACKAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIAITKTQLEKMFKRIM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: GDAP2_HUMAN
Sequence: MDPLGAPSQFVDVDTLPSWGDSCQDELNSSDTTAEIFQEDTVRSPFLYNKDVNGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETIEKVVFAVSDLEEGTYQKLLPLYFPRSLKEENRSLPYLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRKLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSYPPSPDL
What are the official names of this protein?
Ganglioside-induced differentiation-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the GDAP2 family.
Protein: RL33_PROMP
Sequence: MAKKGTRVVVTLECTEARTSSEPRRSNGVSRYTTEKNKRNTTERLELKKFNPHLNKMTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: Y875_VIBPA
Sequence: MLCSIYKSSKKEGTYLYIPKKDDFSQVPDTLMQMFGKPIPVMTIKLDGRKLAQVDIEKVKASLQNDGFFLQVPPPPENLLEKYKEQKAQQKNEQ
What are the official names of this protein?
YcgL domain-containing protein VP0875.
Protein: RL10E_STAMF
Sequence: MPLRPARCYTHFSGPPYTRREYIPGVPQPKIVKFEMGNVHGDYDYRAELVMIEAGQIRHNALEAARVMANKYLSSTVGDQNYFLKIRVYPHHVLRENKMMAFAGADRLQDGMRQAFGKPIGTAARVYPGTIVMEVRVRKEHVEHAKEALRRAASKLPLPARIVFKPLKPGLKPI
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: TIG_BURA4
Sequence: MANVVENLGKLERRVTISLPKDTVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYSGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFEPKQEQAEDAYAFDATFEVYPEVKIGDLATAEVERSTTSIGDAEIDRTLDILRKQRVHYHARGEAGEHGDGGADTAAKNGDRVTVDFVGKIDDVAFQGGTAEDFPFVLGEGRMLPEFETAALGLKVGEQRTFDLKFPDDYHGKDVAGKTAQFTVTMKKIEWPHLPEIDAEFAKSLGIEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFAEQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASASSQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SRP68_DROME
Sequence: MVVQEDNPNTGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKALKYPQGDKRHFKRRDVTIGQLTGKKADERFIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNKLRRACFYALQLQELCNTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGKALPEDEQELYRAKVNEFTPNLRYCAYNISGGASGGKIDEILELRAQGVLENLDVLVSQTKTESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQAVRDEIKQDPKLRSLTTGQTVSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQNVGDGKRVRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLIDIKKWKEAVALYERASNYATEALKGKSSPEFQLQEELKKVVSAIDGCKFSAHAYSVLEDDNSEESGTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYVELPSLEGKLESPGKKGASITGFVKGFLGWGGGGNK
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity).  The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity).  Binds the signal recognition particle RNA (7SL RNA), Srp72 binds to this complex subsequently (By similarity).  The SRP complex possibly participates in the elongation arrest function (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP68, SRP68, Signal recognition particle 68 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SRP68 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Endoplasmic reticulum.
Protein: NFI_KLEP7
Sequence: MDLAALRTQQQQLAASVERADRLDRDPPALIGGADVGFEQEGEITRAAMVLLTWPELELVEYQVARVATSMPYIPGFLSFRETPALLAAWEQLSQKPDLLFVDGHGISHPRRLGVASHFGLMIDVPTIGVAKKRLCGKIGDLGDEPGALAPLMDKNEQLAWVWRSKVRCNPLFISTGHRVGMDSALMWVERCMRGYRLPEPTRWADAVASRRPSFVRWQANHS
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCBV_ECOLI
Sequence: MLKRIIWILFLLGLTWGCELFAHDGTVNISGSFRRNTCVLAQDSKQINVQLGDVSLTRFSHGNYGPEKSFIINLQDCGTDVSTVDVTFSGTPDGVQSEMLSIESGTDAASGLAIAILDDAKILIPLNQASKDYSLHSGKVPLTFYAQLRPVNSDVQSGKVNASATFVLHYD
What is the function of this protein?
Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces.
What are the official names of this protein?
Uncharacterized fimbrial-like protein YcbV.
Protein: NHAB_SALDC
Sequence: MEISWGRAMWRNFLGQSPDWYKLALLVFLIVNPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAVIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_ERYRE
Sequence: MEELQGYFKKARSLQQHFLYPLLLQEFIYTLAYDDGLKGSIFYEPIEFFGYDNKSSLVLIKRLITRMYQQNFLIYSVNDSNQNGLRGHINYFYSHFFYSHIVSEGFSVIVEIPFSLRLVSSPKEKEIPKSQNLRSIHSIFPFLEDKLSHLNNVSDILIPHPIHLEILVPILQYWIQDVPSLHLLRFFLHKYHNLNSFIQNNKTIYVFSKENKRLFWFLYNSYVSECEFLLVFLRKQSCYLRSTSSVAFLERSHFYGKMEHIIIVCCNNFQKTLWPFKDPFMHYVRYQGKAILASRGAHLLMKKWRYYLVNFWQYYFHFWSQPYRMHINPLLNYSFYFLGYLSSVLINPYAVKNKMLENSFLIDTVFKKFDTIIPIIPLIGSLSKAKFCTVSGHPISKPVWGDLSDFDIIDRFGRICRNLSHYHSGSSKKQSLYRIKYILRLSCARTLARKHKSTARALLQRLGSGLLEEFFTEEEQVLSFIFPKTTPFPLHGSHKERIWSLDIIRVNDLVNQII
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: URE3_PROM1
Sequence: MYLSPQEKDKLLVVTAALLAERRLNRGLKLNHPEAVAWLSFQVLEGARDGKSVSTLMNEGTRWLTKEQVMEGVPELIHEVQIEAVFPDGTKLVTLHNPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SK1_NEORO
Sequence: EQFDDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, NeoRh-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PP127_ARATH
Sequence: MILKYNSSYRFYLSSSFLQAMEVDCRRYYVRLLQSCSSRNRETLWRQTNGLLLKKGFLSSIVIVANHLLQMYSRSGKMGIARNLFDEMPDRNYFSWNTMIEGYMNSGEKGTSLRFFDMMPERDGYSWNVVVSGFAKAGELSVARRLFNAMPEKDVVTLNSLLHGYILNGYAEEALRLFKELNFSADAITLTTVLKACAELEALKCGKQIHAQILIGGVECDSKMNSSLVNVYAKCGDLRMASYMLEQIREPDDHSLSALISGYANCGRVNESRGLFDRKSNRCVILWNSMISGYIANNMKMEALVLFNEMRNETREDSRTLAAVINACIGLGFLETGKQMHCHACKFGLIDDIVVASTLLDMYSKCGSPMEACKLFSEVESYDTILLNSMIKVYFSCGRIDDAKRVFERIENKSLISWNSMTNGFSQNGCTVETLEYFHQMHKLDLPTDEVSLSSVISACASISSLELGEQVFARATIVGLDSDQVVSSSLIDLYCKCGFVEHGRRVFDTMVKSDEVPWNSMISGYATNGQGFEAIDLFKKMSVAGIRPTQITFMVVLTACNYCGLVEEGRKLFESMKVDHGFVPDKEHFSCMVDLLARAGYVEEAINLVEEMPFDVDGSMWSSILRGCVANGYKAMGKKAAEKIIELEPENSVAYVQLSAIFATSGDWESSALVRKLMRENNVTKNPGSSWTDC
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At1g77010, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CPXU_BRADU
Sequence: MDMLLNPLNRRHRLRHDIPVVPGAFPLVGHLPAVVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTSLDPDALALLRHKDVSSGLIEDIAPELFGGTLVAQDGIAHRQARDAIQAALLPKGLTLAGIGELFAPVIRARVQRWRERGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDLPGLPLRRGRAARDWIDARLREFVRAAREHASRTGLINDMVSAFDRSDDALSDDVLVANIRLLLLGGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEALFRETLRVHPATPLLVRRALRELRIGQQRIPTGTDLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHFCMGYHLVWLELVQFCIALALTMHEAGVRPRLLSGVEKGRRYYPTAHPSMTIRIGFS
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 BJ-4, Cytochrome P450 117.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RSPO3_MOUSE
Sequence: MHLRLISCFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKVDCDTCFNKNFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEERKETSSSSDSKGLESSIETPDQQENKERQQQQKRRARDKQQKSVSVSTVH
What is the function of this protein?
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444).  Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.  Acts as a ligand for frizzled FZD8 and LRP6.  May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646).  Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:26766444, PubMed:16543246, PubMed:21693646).  Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).
What are the official names of this protein?
R-spondin-3, Cabriolet, Cysteine-rich and single thrombospondin domain-containing protein 1, Cristin-1, Nucleopondin, Roof plate-specific spondin-3.
What is the protein family that this protein belongs to?
Belongs to the R-spondin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYF_CHAVU
Sequence: MQNTNTLNWINKLIYLSISIPIFFLILVTTYPNSVEAYPVFAQQAYKSPREATGRIVCANCHLAKKTVDIEVPQAVLPNTVFEAVVKIPYDMQLKQVLANGKKGNLNVAAVLILPEGFELAPPDRISPDIKEKIGNLSFQSYSPDQKNILVVGPVPGKKYSEITFPILSPDPSINKQTNFLKYPIYVGGNRGRGQIYLDGSKSNNTIYSSSAEGQVVKIIRKEKGGYEIFIDTIDGRKITDIIPPGPEIIVSEGEFVKVDQPLTNNPNVGGFGQANTEIVLQNPLRMEGLILFFISVILAQVFLVLKKKQFEKVQIAEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: COAA_ACTP7
Sequence: MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFLDVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVSDIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWYIARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFT74_MOUSE
Sequence: MASNHKSSAPRPISRGGIGLTGRPPSGIRPPSGNVRVATAMPPTTARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMSDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNMKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIEASIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTSDYDTLKRQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHNASRS
What is the function of this protein?
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium.  Binds beta-tubulin via its basic region.  Required for ciliogenesis (By similarity).  Essential for flagellogenesis during spermatogenesis (PubMed:31004481).
What are the official names of this protein?
Intraflagellar transport protein 74 homolog, Capillary morphogenesis gene 1 protein, CMG-1, Coiled-coil domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the IFT74 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasmic vesicle. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails.