PharMolix/UniProtQA huggingface dataset:
Protein: RL24_BARQU
Sequence: MQKIRKGDKVVVLSGKDKGCSGEVIKVNPKENKAFVRGVNMVKRHQRQTQKQEAGIVSKEAPIHLSNLAIADPKDGKPTRVGFRMNVDGNKVRFAKRSGELING
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SYP_DESHY
Sequence: MRVSQILNPTLREVPAEAEVVSHQLLVRAGLIRKSAAGIYTYLPLGLRVLRKIEQIVREEMDAKGGQEVLLPIIQPAELWRESGRWDLYGQELMRLNDRHNREFCLGPTHEEIITDLIRGEIRSYKQLPLLLYQIQNKYRDERRPRFGLMRGREFIMKDLYSFDRDEAGLAESYKKMYDAYTRIFTRCGLSFRPVEADAGAIGGTGGTHEFMVLAESGEAAVVYCPDCDYAANVEKAECKPAPMAVDAPIGAYRSVDTPGTKTIEQVAEFLKVSKSDLVKSLLYQGDDKLILVLVRGDREINEIKVNNALGPFINLQLAGPEAVLEKLGCEPGYVGPIGAPKNLTVVADLEVPLMAKAVCGANAEDKHYVDAVPEKDFRIDQILDLRMVNAGEPCPQCGSPLKEARGIEVGQVFKLGTKYSKALNAVFLDENGAEHPCVMGCYGIGVSRTMAAAIEQNNDKDGIIWPIPIAPYHVIVVPVNMKDDQVRETGEALYQELLKLGVEAVLDDRDERPGVKFKDADLVGYPLRVTVGSKTLANGEVELRDRKTGEVQLVKVEELAGRIQGMIREALNIG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_SINMW
Sequence: MSAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGMLATVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRATLYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPSATRFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTU_BEUC1
Sequence: MDGAREVRSPRGSTLTARSWQTEAPLRMLMNNLDPDVAERPDDLVVYGGTGRAARDWASYDGIVRTLTTLGDDETLLVQSGRPVGVLRTHEWAPRVLIANSNLVPDWATWPEFRRLEHLGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAEKVGRPDDDGVASLAGTLTLTAGCGGMGGAQPLAVTLNGGVCLVVDVDPERLRRRVATRYLDEVADGLDDAVARCEAAKLERRALSVGLVGNAATVYPELLRRGVEIDVVTDQTSAHDPLSYLPEGVELGEWHEAAEAKPEEFTDRARESMARQVAAMVGFLDAGAEVFDYGNSIRDEARQGGYDRAFAFPGFVPAYIRPLFSEGKGPFRWAALSGDPADIAATDRAVLDLFPDDAKLHRWIRAAGERVAYQGLPARICWLGYGERHLAGLRFNEMVASGELSAPIVIGRDHLDAGSVASPYRETEAMADGSDAIADWPLLNALVNTASGATWVSIHHGGGVGIGRSIHAGQVSVADGTELAAAKLERVLTNDPGMGVIRHVDAGYARADEVAAERGVRVPMRES
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_AZOVD
Sequence: MDLTPREKDKLLIFTAGLLAERRLARGLRLNHPEAVAYISAALLEGARDGHTVAELMHIGTTLLSRDQVMEGVPEMIPEIQIEATFPDGTKLVTVHQPIA
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK19_PORPU
Sequence: MKDNNIKLSLLMKSVEQPLMKTELPEIKVGDTIRLGLLVKEGSKTREQLCEGVVLSRKKRKSLNTSLTLRCSFQGVGVERVFFLNSPRVTFVKVIRRAKVRRAKLYYLRDLLGKASRLKQIFN
What are the official names of this protein?
50S ribosomal protein L19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HPLN1_HUMAN
Sequence: MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
What is the function of this protein?
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
What are the official names of this protein?
Hyaluronan and proteoglycan link protein 1, Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein.
What is the protein family that this protein belongs to?
Belongs to the HAPLN family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PP6R3_HUMAN
Sequence: MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQTNTSSINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGDNLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPGDTSVNGPV
What is the function of this protein?
Regulatory subunit of protein phosphatase 6 (PP6).  May function as a scaffolding PP6 subunit.  May have an important role in maintaining immune self-tolerance.
What are the official names of this protein?
Serine/threonine-protein phosphatase 6 regulatory subunit 3, SAPS domain family member 3, Sporulation-induced transcript 4-associated protein SAPL.
What is the protein family that this protein belongs to?
Belongs to the SAPS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DAPE_BURCM
Sequence: MSATLALTEQLIARASVTPDDQHCQQLMTERLAALGFECETIASHGVTNLWAVKRGADGRDGKLLAFAGHTDVVPTGPLEQWTSPPFVPTHRDGKLYGRGAADMKTSLAAFVVASEEFVAAHPGHRGAIAFLITSDEEGPATDGTVKVVELLETRGERVDYCIVGEPTSSAELGDVVKNGRRGSMSGELVVKGVQGHIAYPHLAKNPIHLLAPALAELAAEQWDAGNEYFPPTTWQVSNLHAGTGATNVIPGHADLMFNFRFSTASTVEGLQARVHAILGKHGLEYTLKWSVSGLPFLTPRGDLSNALENAIRAETGLTTELSTTGGTSDGRFIARICPQVIEFGPPNGSIHKIDEHIDVRFVDPLKNVYRRVLEQLIA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: YN06_YEAST
Sequence: MWLINHTYKLLSYFLRKASNRFFNSSSSSFSCSFLVFLFVVFFSDCFFSITSFLISFGILSSFLIFSLFCLGFLTVIGCLASALSLSSLSKAKIGFSSSLSSISPEGSLKSEEMLEDDEDKEFSSLLYGTSYVFAISFK
What are the official names of this protein?
Putative uncharacterized protein YNL266W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYM_DEHMB
Sequence: MSERIFIGVAWPYANSQLHLGHVAGAYLPADIFARYHRTRGDEVLMVSGSDMHGTPITIRAEQEGITAAEVAERYHQRFMASWPKLGISWDFYTSTATANHARTAQEMFLSLYEKGYIYKNTVCQPFCSHCNRFLPDRYVEGTCPHCKYEGARGDQCDNCGKPLNAAELLNFRCKNCGNPPEFRETEHFFLKLSAFEEELIRWVETKTHWRTNVLNFTLRYLKEGLKDRAITRDLDWGVPLPLPGYEGKRLYVWFEAVIGYLSASKEWAASKGQPNAWQKYWGVDTKSYYFIGKDNIPFHTIIWPAMLMGKGGLNLPYDVPSNEYLTTESQKFSKSRNNAIWVDDVLSRYGVDTLRYLLSANMPESSDTDFSWREFVRRNNDELVATYGNLAQRVLTMVCRNYDNKVPEYGELDERSLTLIEKTAAMLCETDKALYNCNFREAIRLAMALAQEANRYLDEKAPWKEIKVDKAAAARSLYVAMVALSGLRVAFYPFLPESSGRLSTYLGFGSELEKEGWILKMPVVGQELTPPEPLFKKLEDSVVEEETARMGL
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_BOTIS
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNQKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSFRCKPRDIITTKDNQRSKRLVQNYIASSDPGKLPKHLTVDTLQYKGLVKKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y751_OCEIH
Sequence: MENGRNWRNRELRQHVKVIDGTVSPTLLLKNATYLNVHTKQWLEANIWIYKDRIIYVGEKLPNQSQETEVYDCEGRFVVPGYIEPHAHPFQLANPEITAMHAAKTGTTTLVNDNLTWYLLTNKKKAFSIIDQFNKLPISMFWWSRYDSQTTLQEENHFINTNDVLDWINHPSVVQGGELTDWPSLLAGDDRLLYWIQETKRNGKPIEGHLPGASLRTLTKMKLLGISADHEAMTGKDVMNRLQLGYMVGLRYSPIRPDLPAILEELLESGLTTFDQLTFTMDGPTPYFMKDGVINTCIQIAIDKGIPLEDAYRMGSFHAAKHLRMDEELGSIAPGRIAHINILQEKENPNPIGVLAKGEWIVKETKEIDIPSIIDWSKYEINEMNIDWNLTEDDLQFSVPVGMDVVNDVIIKPYTIDSDVSFEELNEEKGEQFILLIDRKGKWRVNTIIRGFAPKLGALISSYSASGDIIIIGNSKKDIFIAWNRLKEIKGGIILVNNGEILTEIPLTLGGSLPNEPMEQMIKYDKQLKDTLQKYGFAFYDPVYSLLFLSAFHLPFFRITQKGLLDVKNRDILFPATMR
What are the official names of this protein?
Putative adenine deaminase OB0751, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: PKS1_ARATH
Sequence: MVTLTPSSASTPKTSFDFMKNNNSHSSLYVSSSSYLSSKEDALVTTKKLMEPSKTLNMSINPKQEEFGDEKKMVKKAPEDPEIGVFGAEKYFNGDMDSDQGSSVLSLTNPEVERTVVDSKQSAKKSTGTPSVRSESSWNSQSVLLQNKLVNSCNSSFKEKKNSNGQIQKVTNNKKSFLANLGCKCACSDGDSVDVEEKTSVKRSADPNISVITMRSSADMNTELIKIQKQEELSQRKSLEVFGSPVAIEKKSSVVQKKLPLPPWKSRTEEDDTKSEGSDSSSDLFEIEGLTGNPKPFLTRQGSDPASPTCYAPSEVSVEWSIVTASAADFSVMSECATSPVRRNRPTQIPRIPITAKSAPQRRKSSSSSGGNGFLMSCKSHKSVMVSGDLDRRSSMNKTQPSYVPRFPMETTKPKSFETRRRISNSSISHTQSSLLYSQ
What is the function of this protein?
May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling.  Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling.  Acts positively in PHOT1 signaling.  Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism.  Involved in the control of leaf flattening and leaf positioning.  Promotes negative root phototropism and negatively regulates root gravitropism.  May act by controlling auxin homeostasis.
What are the official names of this protein?
Protein PHYTOCHROME KINASE SUBSTRATE 1.
What is the protein family that this protein belongs to?
Belongs to the PKS family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL5_HAEIN
Sequence: MAKLHDYYRDQVVSELKNKFGYKSVMQVPRIEKITLNMGVGEALTDKKLLDNAVADLAAISGQKPLVTKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKNDEEGQALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: YIDD_THEMA
Sequence: MKKLLIMLIRFYQRYISPLKPPTCRFTPTCSNYFIQALEKHGLLKGTFLGLRRILRCNPLSKGGYDPVPEEFSFKPRRRWS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DHGL_DROPS
Sequence: MATSPSSCDCLVGVPTGPTLASTCGGSAFMLFMGLLEVFIRSQCDLEDPCGRASTRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNFIGSDIDYRYNTEPERMACLSSMEQRCYWPRGKVLGGTSVMNGMMYIRGNREDYDDWAAQGNPGWSYQDVLPFFKKSEDNLELDAVGTEYHAKGGLLPVGKFPYNPPLSYALLKAGEEMGFSVQDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTVTKVLIHPGTKNVVGVEVSDQFGSMRKILVKKEVIVSGGAVNSPQILLLSGVGPKEDLQKVNVRPVHHLPGVGKNLHNHVAYFTNFFIDDADTAPLNWATAMEYLLFRDGLMSGTGISDVTAKMATRWADRPNLPDLQLYFGGYLASCARTGQVGELLSNNSRAIQIFPAVLNPKSRGYITLRSADPLDPPRIFANYLTDERDVKTLVEGIKFAIRLSQTSPLKQYGMRLDKTVVKGCESHAFASDAYWECAVRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGVRGLRVMDTSIMPKVTAGNTHAPAVMIAEKGAYLLKRAWGAKVURVDATWTLHRVI
What are the official names of this protein?
Glucose dehydrogenase [FAD, quinone].
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted as part of the seminal fluid transferred to females.
Protein: GLF_MYCTO
Sequence: MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVHKYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPEQARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELPAANITRLPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIEVRLNTDWFDVRGQLRPGSPAAPVVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQGTAVMNYNDLDVPYTRIHEFRHFHPERDYPTDKTVIMREYSRFAEDDDEPYYPINTEADRALLATYRARAKSETASSKVLFGGRLGTYQYLDMHMAIASALNMYDNVLAPHLRDGVPLLQDGA
What is the function of this protein?
Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a key building block for cell wall construction in Mycobacterium tuberculosis.
What are the official names of this protein?
UDP-galactopyranose mutase, UGM, UDP-GALP mutase, Uridine 5-diphosphate galactopyranose mutase.
What is the protein family that this protein belongs to?
Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.
Protein: ASSY_CHICK
Sequence: MAEPRDTVVLAYSGGLDTSCILVWLKEQGYTVIAFLANIGQTEDFDAAQKKALALGAKKVYIQDVCREFVEDFIWPAVRANALYEDRYMLGSALARPCIARHLVLIAQEEGARYIAHGATGKGNDQVRFELGCYALCPSIKVIAPWRMPEFYQRFPGRRELMEYAQKHGIPVPVTPKAPWSMDENLMHISYEAGILENPKNRAPLDLYTKTCNPTTSPDVPDELEIEFEKGVPVKVTNTRNGVTHRSALELFVYLNDIASKHGVGRVDIVENRFVGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLSLKFSELVYNGFWYSPECEFLKHCIARSQQAVAGTVHVSVFKGQVYVLGRESPHSLYNEELVSMDVQGDYEPADATGFININALRLKEYHRLQSKVSTKQDE
What is the function of this protein?
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals.  Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TERT_RAT
Sequence: MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSRLVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFGFALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVGGNFTNLGSAHQIKNSGHQEAPKPQALPSRGTKRLLSLTSTNVPSAKKARFEPALRVDKGPHRQVVPTPSGKTWAPSPAASPKVPPAAKNLSLKGKASDPSLSGSVCCKHKPSSSSLLSSPPQDAEKLRPFTETRHFLYSRGGGQEELNPSFLLNSLPPSLTGARRLVEIIFLGSRPRTSGPFCRTRRLPRRYWQMRPLFQQLLMNHAKCQYVRFLRSHCRFRTANQRVPDAMDTSPSHLTSLLRLHSSPWQVYGFLRACLRELVPAGLWGTRHNERRFLKNVKKFISLGKYAKLSLQELMWRVKVEDCHWLRSSPEKDTVPAAEHRLRERILAMFLFWLMDTYVVQLLRSFFYITETTFQKNRLFFYRKSVWSKLQSIGIRQQLERVQLRELSQEEVKHHQDTWLAMPICRLRFIPKLNGLRPIVNMSYGMDTRAFGKKKQTQCFTQSLKTLFSVLNYERTKHPNLMGASVLGTSDSYRIWRTFVLRVRALDQTPRMYFVKADVTGAYDAIPQDKLVEIVANIIRRSESMYCIRQYAVVQKDSQGQVHKSFRRQVSTLSDLQPYMGQFTKHLQDSDASALRNSVVIEQSISMNETGSSLLHFFLRFVRHSVVKIDGRFYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQQDGLLLRFVDDFLLVTPHLAHAKAFLSTLVHGVPEYGCMINLQKTVVNFPVETGALGGAAPHQLPAHCLFPWCGLLLDTRTLEVFCDYSGYGRTSIKMSLTFQGVSRAGKTMRYKLLSVLRLKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIRLPFGQHVRKNHAFFLGIISNLASCCYAILKVKNPGVSLRAKGAPGSFPPEATRWLCYQAFLLKLAAHSVTYKCLLGPLRTAQKQLCRKLPEATMTLLKTAADPALSTDFQTILD
What is the function of this protein?
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes.  Active in progenitor and cancer cells.  Inactive, or very low activity, in normal somatic cells.  Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.  Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'.  The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension.  More active on substrates containing 2 or 3 telomeric repeats.  Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers.  Modulates Wnt signaling.  Plays important roles in aging and antiapoptosis (By similarity).
What are the official names of this protein?
Telomerase reverse transcriptase, Telomerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the reverse transcriptase family. Telomerase subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-697. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT (By similarity).
Protein: ASD_METKA
Sequence: MMAPGWWKFVTPPAALGAALFPWSRPLSFLCLGTAAFLAFFFRNPPREPPSDPSLAVSPADGRLLGYVMEAGEASDDELSSYLDDPITVSVFMSPLDVHVNRAPLDGRVVEAEILKGRFRPAFRKDSATENNRAVLLFDGDPPFVVRLVSGAVARRIDLYVQEGDEVNKGEPIGMIRFGSRVDLAVPRSSVEELLVRKGDSVKAGETPVIRVKR
What is the function of this protein?
Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
What are the official names of this protein?
Putative archaetidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MYH3_MOUSE
Sequence: MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYVKGKIKSSQDGKVTVETEDSRTLVVKPEDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDACRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE
What is the function of this protein?
Muscle contraction.
What are the official names of this protein?
Myosin-3, Myosin heavy chain 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Protein: COBS_SALG2
Sequence: MSKLFWAMLAFISRLPVPSRWSQGLDFEQYSRGIVMFPFIGLILGGVSGLIFILLQPWCGIPLAALFCILALALLTGGFHLDGLADTCDGIFSARRRERMLEIMRDSRLGTHGGLALIFVLLAKILVVSELALRGTPMLAALAAACAAGRGSAVLLMYRHRYAREEGLGNVFIGKVSGRQTCITLGLAVIVATVLLPGMQGLAAMVVTCAAIFILGQLLKRTLGGQTGDTLGAAIELGELIFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TX20B_PHONI
Sequence: MWLKIQVFLLAITLITLGIQAEPNSSPNNPLIEEEARACAGLYKKCGKGASPCCEDRPCKCDLAMGNCICKKKFIEFFGGGK
What is the function of this protein?
Antagonist of L-type calcium channels (Cav1/CACNA1).  Induces immediate clockwise gyration and flaccid paralysis after 6 hours at dose levels of 5 ug per mouse.
What are the official names of this protein?
Omega-ctenitoxin-Pn1a, Omega-CNTX-Pn1a, Neurotoxin Tx3-2, PNTx3-2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 02 (plectoxin) family.
What are the subcellular locations of this protein?
Secreted.