PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_LEUMM
Sequence: MLPDFTPIEKLTTQDAQQETARLQKQLVQYGTAYYEDDAPLVEDYIYDALYARLVALEEKFPQYVIPDSPTQNVGSADTKSELQKVVHPAPMLSLGDVFSLDELNDWDARTTKSLGNQAPYNLELKIDGLAVALTYVDGQLVQASTRGNGIVGEDVTANVKTIKAIPKKLTEPLTIEVRGEIYMPKASFAALNKQREADGLEPFANPRNAAAGSLRQLNVKITKSRNLAAFVYYTAEPEMLGVTTQSGALERFAELGLPTDTHNRVINKMADIADYIDEYTSERESLSYGIDGVVVKVNQLDLQFDLGNTVKIPRWAIAYKFPPEEALTIVCDIEWTVGRTGAVTPTAVMDPVLLAGTTVQRASLHNPDYLREKDIQIGDTVTLHKAGDIIPEIGQVILEKRPTDSETYQVPTICPACESNLVHIEGEVALRCINPFCSAQIQEGLTHFASRNAMNIDGMGPRVVGQLLKAGYIKDVASIYRITVEQLLTLDKFQEKSAVKLIDAINSSKENSLERLLFGLGIRMVGAKAARLIAEKFRTLSAVSEASVEDIANINGIGHTIAQSIVQYFSTPESKQLLVELASSGVNQSYLSDTVIDENSFFYGKKVVLTGKLEQSSRPAATKWLQDHGANVAGSVSVKTDLVIAGEAAGSKLDKASQLGVTVWTEQQFVDEQVKEDGK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ACKA_CAMJD
Sequence: MKILVLNSGSSSIKFKFFDNKIIKASGLVEKIGEQNSKVILKNVLNNESFERELTINNHEEGLSIVNELFKESGILADLNTLDGCGHRIVHGGRNLSEHCLVDDYVLKEIDRVSIFAPLHNPAHLAGIKTMIKAAPSVANVAIFDTAFHRTMPDFAYMYALPYDFYDKHNIRRYGFHGTSHAFVSSRAASLLEKDKSELNVISAHLGNGASVCAIEKGKSVDTSMGFTPLEGLVMGTRCGDLDPAILPFISHLKGLTIEEIDTLMNKKSGVYGICGYNDFRDIEREIEQGNDKARLALDMFCYRLVKYIGAYFAVLPKTDAIVFTGGIGENDSLVRQKVCERLAHLGIELDFELNKQRISGERMINHANSKVKVLVIPTDEELEIARITEELIGKN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_CRYJA
Sequence: MTRVKRGYIAKKRRKKILAFVSGSRGAHSKLFRVANQQKSRALVSAHRDRLKRKRDFRRLWITRINAASRANGVSYNKFIQFLYKRQLLTNRRTLAQIAVLNNNCFSMMLENILVS
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MASZ_RHIME
Sequence: MDRVEKYGLQIDAGLHRFLVEEAMPGTGVDADRFFSAFSDLVHDLGPKNRALLVKRDELQARLDGWYREHGAPVDMEAYEAFLREIGYLLPEGPDFYVSTANVDSEIATIAGPQLVVPVMNARYALNAANARWGSLYDALYGTDAIAETDGAERGKGYNPKRGAKVIAWAREFLDASAPLAAGRWSDAKSFSVEGATLTVTLADGTKSAPRNSVQFAGYAGDPAAPSEIVLRRNGLHIVIVLDATTPIGKADAAGISDVVLESAITTIMDCEDSIAAVDAEDKVLVYRNWLGLMKGDLEEEVTKGGRAFTRRLNPDRAYTAPDGATLTLPGRSLMLVRNVGHLMTNPAVLDRDGEEVPEGLMDAMVTALIALHDIGRNGRRANSRSGSMYVVKPKMHGPEEVAFACEIFARVEAALGLPANAMKMGIMDEERRTTVNLKECIRAARERVVFINTGFLDRTGDEIHTSMEAGPMIRKGDMKQAPWISAYENWNVDVGLECGLSGHAQIGKGMWAMPDLMAAMLEQKIVHPKAGANTAWVPSPTAATLHATHYHRVNVAEVQASLKSRTRAKLADILSVPVAARPNWTEEEIQRELDNNAQGILGYVVRWVDQGVGCSKVPDINNVGLMEDRATLRISAQHMANWLHHGIVSEAQIVETMQRMAAIVDGQNAGDPNYQPMAGRFEESIAFQAALDLVLKGREQPNGYTEPVLHRRRLELKAKQGA
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_PYRNV
Sequence: MVKIKVRSSAWYDGVDNASHRSYLRAVGFTEEDFAKPLVGVLAAWSELGPCNYHTLDLARYVKEGVKEAGGVGLTAPTIVVNDGINMGTPGMRYSLISRDLIADTIEAQFNAHGVDAWVGIGGCDKTQPGIMMAMVRLDLPAVYLYGGTAEAGWLGERELTIEDTFEAVGSYLAGKITLEELKRIEELSFPTYGTCQGLFTANTMAMLSEALGLALLGSASPPATSARRRAYAVASGRAVLKAAELGVTPRRVVTYDAIYNAAVTLFATAGSTNAILHLLAIAHEAGVKFTLDDFDEISRRVPVIAALRPAGPYAMQDLDRIGGVPRILKKLYKAGFLRPEALTVEGETIGKLLERWQPPAVPEDGILYSVEKPYKPYSGIRILRGNLAPDGAVMKIGAADKLKFEGTAKVYNGEAEAFKAVAAGEIKPGDVVVIRYEGPKGAPGMPEMLKVTAAIVGAGLGEAVALVTDGRFSGATRGIMVGHVAPEAAVGGPIALVENGDKIAIDGETGRITLQIPQEELERRRKNWTPPPPKYSGGLLAKYAALVQQADKGAVTTPPR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: EOMES_HUMAN
Sequence: MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP
What is the function of this protein?
Functions as a transcriptional activator playing a crucial role during development.  Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification.  Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.  Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
What are the official names of this protein?
Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPDA_PSEA7
Sequence: MTEQQPIAVLGGGSFGTAIANLLAENGQAVRQWMRDPEQAEAIRSRRENPRYLKGVKVHPGVEPVTDLERTLADCQLIFVALPSSALRKVLQPHQLALTDKLLVSLTKGIEAHTFKLMSEILEEIAPQARIGVISGPNLAREIAEHELTATVVASEDDELCARVQAALHGRTFRVYASRDRFGVELGGALKNVYAIMAGLAAAMDMGENTRSMLITRALAEMTRFAVKLGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGHALGEGLSLEQAVSRLGETAEGVNTLRVLKEKSDEMQVYMPLVAGLHAILFEGRTLAQVIQLLMRGEPKTDVDFIPTTGF
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_CALS4
Sequence: MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQLANDVREKIENMILERREKIAKEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRIFLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFYITSDILLRTQTSPVQVRTMEKTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQTKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYTGFAFGLGIDRIAMLKYGIEDLRLLFENDMRFIEQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHM2_METEA
Sequence: MKTTLIAAAIVALSGLAAPALAYDGTKCKAAGNCWEPKPGFPEKIAGSKYDPKHDPKELNKQADSIKQMEERNKKRVENFKKTGKFEYDVAKISAN
What is the function of this protein?
Catalyzes the oxidation of primary alcohols including methanol.
What are the official names of this protein?
Methanol dehydrogenase [cytochrome c] subunit 2, MDH small subunit beta, MDH-associated peptide, MEDH.
What is the protein family that this protein belongs to?
Belongs to the methanol dehydrogenase subunit 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CACO2_HUMAN
Sequence: MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
What is the function of this protein?
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation.  Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324).  Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791).  Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791).  May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
What are the official names of this protein?
Calcium-binding and coiled-coil domain-containing protein 2, Antigen nuclear dot 52 kDa protein, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52, Nuclear dot protein 52.
What is the protein family that this protein belongs to?
Belongs to the CALCOCO family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.
Protein: Y549_BUCA5
Sequence: MSDTKKSFKNVLEFVHKFRRKNKIKREISDIEKKIRDNQKRILLLDNLIQYITLDMNYEEIKKIIFMMKSDYEDRIDDYIVKNAELSKEKRNLSKELKFIIK
What are the official names of this protein?
UPF0265 protein BUAP5A_549.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: PHS_BRASO
Sequence: MVERLSAEARASALRDLSGWAELDGREAISRTFTFRDFNEAFGFMTRVALIAEKRDHHPEWRNVYRTVEVVLATHDAGGVTMLDIELARAMDAIAAAISG
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ORN_PSEA7
Sequence: MQNPQNLIWIDLEMTGLDPDRDVIIEMATIVTDSDLNTLAEGPVIAIHQPEEVLAGMDEWNTRQHGQSGLTQRVRESTVSMAEAEAQTLAFLEQWVPKRSSPICGNSICQDRRFLYRHMPRLEGYFHYRNLDVSTLKELAARWAPQVRESFKKGNTHLALDDIRESIAELRHYRDHFIKL
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVC9
Sequence: MAARLCCQLDPTRDVLCLRPVGAESRGRPVSGPLGDLPSPSASPVPTIDRAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNTHMILPKVLHKRTLGLPAMSTIDLEAYFKDCLFKDWEELGEEIRLKVFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: 3BHS2_MOUSE
Sequence: MPGWSCLVTGAGGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETRKEFFNLETSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIVLNGHEEECHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKFNTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSFDDISYTLSKEWGFCLDSSWSLPVPLLYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLSGSTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ
What is the function of this protein?
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.  The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3-beta-HSD II.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Protein: ADEC1_JANSC
Sequence: MEPTPFPSWQDVASALVATAAGRAPADLVIRGAKVVLVQTREVMDGWDVAIKHGRFAYVGPDASHCIGEDTQVEELSGHYLIPGLCDGHMHIESGMLTPAEFTRAVIPHGTTSMFTDPHEIANVFGLRGVRLMHDEALLQPINVFTQMPSCAPSAPGLETTGFEIGPDDVSEAMAWPGIVGLGEMMNFPGVVNGSQQMLAEIAATQAAGKTVGGHYASPDLGPAFHAYAAGGPADDHEGTSETDAMARMRQGMRSMIRLGSAWYDIESQITAITERGLDPRNMIICTDDCFAKTLVEDGHMNRAVRHAIDCGCDPLIALQMATINTATHFGLEREIGQIAPGRRADMIVTRDLRTLPIEVVYARGQRVAQFGECLVECPHLDWPTDTRHSVNLGKSLTAADFEIRSDAAEVTANVIGVVENQAPTKALTQTLPVRHGVVEPDGIAQIALVERHRGTGGVTNAFVSGFGYGPGMAMASTVAHDSHHMIVVGTDRAMMAKAAMRLGEVGGGITLWQDGTERALVELPIAGLMSDRPATEVAAKVTQLVEAMEAAGCTLNNAYMQHSLLALVVIPELRISDLGLVDVRTFELTPVLP
What are the official names of this protein?
Adenine deaminase 1, Adenase 1, Adenine aminase 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: YIM1_YEAS2
Sequence: MSDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHAAALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHIYGERGTLTHYLILNPAKDIPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDFKKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVPYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNNKANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPIDSVYEFDQYKEAIDRLMSNRAKGKVVVKMK
What are the official names of this protein?
Protein YIM1.
What is the protein family that this protein belongs to?
Belongs to the YIM1 family.
What are the subcellular locations of this protein?
Lipid droplet. Mitochondrion.
Protein: IL13_PANTR
Sequence: MALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGVYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN
What is the function of this protein?
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection.  Synergizes with IL2 in regulating interferon-gamma synthesis.  Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity).  Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity).  Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity).  Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils.  Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6.  Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
What are the official names of this protein?
Interleukin-13, IL-13.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MPT53_MYCTU
Sequence: MSLRLVSPIKAFADGIVAVAIAVVLMFGLANTPRAVAADERLQFTATTLSGAPFDGASLQGKPAVLWFWTPWCPFCNAEAPSLSQVAAANPAVTFVGIATRADVGAMQSFVSKYNLNFTNLNDADGVIWARYNVPWQPAFVFYRADGTSTFVNNPTAAMSQDELSGRVAALTS
What is the function of this protein?
Disulfide oxidoreductase that catalyzes the oxidation of reduced, unfolded secreted proteins to form disulfide bonds.  Despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase.
What are the official names of this protein?
Soluble secreted antigen MPT53.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: URIC_MOUSE
Sequence: MAHYHDNYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHVLAKLRGIRNIETFAMNICEHFLSSFNHVTRAHVYVEEVPWKRFEKNGIKHVHAFIHTPTGTHFCEVEQMRNGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCKWRYQRRDVDFEAIWGAVRDIVLQKFAGPYDKGEYSPSVQKTLYDIQVLSLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLPSRL
What is the function of this protein?
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
What are the official names of this protein?
Uricase, Urate oxidase.
What is the protein family that this protein belongs to?
Belongs to the uricase family.
What are the subcellular locations of this protein?
Peroxisome. Mitochondrion.
Protein: DTD_BACC7
Sequence: MRVVLQRSKEASVTVDGEIVGQIPFGLTLLVGITHEDTEKDATYIAEKIANLRIFEDESGKMNHSVLDVEGQVLSISQFTLYGDCRKGRRPNFMDAAKPDYAERLYDFFNEEVRKQGLHVETGKFGAMMDVSLINDGPVTLIVESK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNFG_ECOLI
Sequence: MTTQYGFFIDSSRCTGCKTCELACKDFKDLGPEVSFRRIYEYAGGDWQEDNGVWHQNVFAYYLSISCNHCDDPACTKVCPSGAMHKREDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEKGHMTKCDGCYSRVAEGKQPICVESCPLRALEFGPIEELRQKHGTLAAVAPLPRAHFTKPNIVIKPNANSRPTGDTTGYLANPEEV
What is the function of this protein?
Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
What are the official names of this protein?
Probable anaerobic dimethyl sulfoxide reductase chain YnfG, DMSO reductase iron-sulfur subunit YnfG.
Protein: YFMR_SCHPO
Sequence: MSNAPSNTPTGFNYKPGHTLYIRNFGTDMRARTLGQAFEKWGRIVRCDIPISSNPQAHRYAFVEFEEREKAELAHEKMRNAKIGNDIIFVEWAKSRERYHRDDKRRLSNYA
What is the function of this protein?
Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.
What are the official names of this protein?
Putative splicing factor C222.18.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMO_SALA4
Sequence: MSNVTHQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPRYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLQHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGDVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGVWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGAGANELPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIVDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDIVRVKVENADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.