PharMolix/UniProtQA huggingface dataset:
Protein: ATG7_SCHPO
Sequence: MFVGKALQFQSFHSSIDATFWHQLSNYKVEKQKLDASPLTIHGKFNTYSRGNISIVFGEAPSNSNIKDCLAEGTLLNANTPQEFTNADVKKIREEIGEVLLNSIKNGVVSERPNELLRFLIFSYADIKAYKYHYWCLFPSFKETPHWIVKDLSPAESLIPSGPILSQIREFLSTADYYQRPFFLLIKSTLDEWTIAPLKELSHCVDKSLQFYLVAEDSVQLAEYPSWPVRNILAFAFIKFKLKVINLFLYRDGINSDTLSKSILIKVEADKDMILEAPLSIVGWERNGKGVLGPRVVNLSTVLDPFVLSESASTLNLSLMRWRLVPQLDLDRIQNSKCLLLGAGTLGCGVARNLLSWGVRHVTFVDYSTVSYSNPVRQSLFTFEDCKRKLPKAECAAQRLKEIYPNMFSTGYNISIPMLGHPIYEAGIEKTMHDYETLENLISTHDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMRHGSVLQKENRLGCYFCNDIFAPSNSLVDRTLDQTCTVTRSGCANIATAIAVELFVSLLQHPNGHAAPVLNEDQTVLGELPHQIRGFLHNFSLMKISGMAYPQCSACSECIINEWNREKWMFVLRAINEPDYVEELCGLREVQALGEIAGTMEEWISDKESVIL
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).  Plays a role in meiosis and sporulation.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: OBG_CALS4
Sequence: MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFKYKRKYIAENGENGKSKNQYGKDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKGGKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLADVGLVGFPNAGKSTLLASCSRARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKMLIHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEIKKRGYEVYPISALTKEGLDALLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVKGNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVIDALKEKGFKSGDVINVRDFEFEYYE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STA5A_SHEEP
Sequence: MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQVTQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYVHVSSRTRTTAAPWSWLRCIRHILYNEQRLVREATNGNSSAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRHDWRGMEAPPRSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQRTGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLLFLAQKLFNNSSSHLEDYNGMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTREGSIRSLADRLGDLNYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVSASADSAGSSATYMDQAPSPAVCPQPHYNMYPQNPDPVLDQDGEFDLDETMDVARHVEELLRRPNGQSGPLSPPPAGLFTPARGSLS
What is the function of this protein?
Carries out a dual function: signal transduction and activation of transcription.  Mediates cellular responses to the cytokine KITLG/SCF and other growth factors.  May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.  Binds to the GAS element and activates PRL-induced transcription.  Regulates the expression of milk proteins during lactation.
What are the official names of this protein?
Signal transducer and activator of transcription 5A, Mammary gland factor.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein: ECHD1_XENTR
Sequence: MGIFVCRNSLRMLNVRWLYHRCLSLYNSNHGFNEAKIKEKLAQFTGGSVDLSKMDNGIAEICINNPSRMNAFTGTMMIELEERISDLENWKNGKGLIVYGAENTFCSGSDLNAVKAISNPQEGMMMCMLMQNTLTRLQRLPLISVALIQGKALGGGAELCTACDFRLMTEGSEIRFVHKQMGLVPGWGGAARLIHLIGSRHALKLLSGALRVHPENALELGLADNILLGTEDGFLSEAENWIMPYIKGPSDVSRAVKKVIISGREQKLEDALRTEKEIFGTVWGGLANLQALAKGTKHK
What is the function of this protein?
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading.  Also has methylmalonyl-CoA decarboxylase activity at lower level.
What are the official names of this protein?
Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SFSA_THEPX
Sequence: MVITNPIVYGKFIKRINRFEAYVELNSGEKTLVHVPNTGRCKEIFVPGAEVILEVRDRQGRKTPYELAFAYKGKRLISIDSQVPNKVVLESIKMGLIEEFKGYDIVEKEKTFGNSKFDIKLTKGKEICYVEVKGVTLEVEGVAKFPDAPTERGRKHLKELIKVKKEGMRAAVIFLIQMDDIKYFTPNDEQDPEFGKFLREAVGKGVEAYAYTCDVGENYVFLKDRVEVVL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: CAPSP_ASFK5
Sequence: MATRAATKMAGKKEHQYCLLDTQEKRHGHYPFSFELKPYGQTGANIIGVQGSLTHVVKMTVFPFMIPFPLQKTRIGDFIGGRVYLFFKELDMQAFSDVNGMQYHFEFKVVPVSSSQVELLPVNNTYKFTYAIPELQYLTPIFYDLSGPLDFPLDTLSVHVDSLTHHIHLPIQNHNLTMGDRVFVSGYKHLQTIETCKNNIIFIKDIPPLSSEKINLYIPKNRIRIPLYFKSLKASK
What is the function of this protein?
Forms the penton at the fivefold vertices of the icosahedral capsid (By similarity).  Together with the minor capsid proteins (p17, p49, and M1249L), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid (By similarity).
What are the official names of this protein?
Penton protein H240R, pH240R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus H240R family.
What are the subcellular locations of this protein?
Virion.
Protein: HIC2_HUMAN
Sequence: MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS
What is the function of this protein?
Transcriptional repressor.
What are the official names of this protein?
Hypermethylated in cancer 2 protein, Hic-2, HIC1-related gene on chromosome 22 protein, Hic-3, Zinc finger and BTB domain-containing protein 30.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNJ1_STAHJ
Sequence: MKQLHANEVGVYALGGLGEVGKNTYAIEYKNEIVIIDAGIKFPDDNLLGIDYVIPDYTYLEQNQDKIVGLFITHGHEDHIGGVPYLLKQINVPIYGGPLALGLIRNKLDEHNLLRNASLNEITEDSVIKSKHFEISFYLTTHSIPEAYGVIIDTPEGKIVHTGDFKFDFTPVGEPANIAKMAELGKEGVLCLLSDSTNALVPDFTLSEREVGQNVDKIFRNCKGRIIFATFASNIYRVQQAVEAAIKYNRKIVTFGRSMENNIKIGMELGYIKAPPETFVEPNKINNIPKHELLILCTGSQGEPMAALSRIANGTHKQIKIIPDDTVVFSSSPIPGNTKSINRTINALYKAGADVIHSKISNIHTSGHGSQGDQQLMLRLIQPKYFLPIHGEYRMLKAHGQTGVDCGVKEENVFIFDIGDVLALTHDSARKAGRIPSGNVLVDGSGIGDIGNVVIRDRKLLSEEGLVIVVVSIDFNTNKLLSGPDIISRGFVYMRESGQLIYDAQRKIKTDVISKLNANPNIQWHQIKSSIIETLQPYLYDKTARRPMILPVIMKVNED
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
What are the official names of this protein?
Ribonuclease J 1, RNase J1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_CHRSD
Sequence: MWIGVVSLFPEMFEAITRYGVTGRAVDQGLLEVDFWNPRDYATDKHRTVDDRPYGGGPGMLMKVATLRPAIAEARRDAERRGCAPARTRVVYLSPQGRRLDQRGVRELADLEALIVVAGRYEGIDERVVEADIDEEWSIGDYVLSGGELPAMVMVDAVSRLVPGVLGHGDSALEDSFSEGLLDCPHYTRPETIDGRQVPDILLSGNHAAIRRWRLKQSLGRTWLRRPELLEGRALDREQQRLLDEFIAEQATSQNVGRTEERRPLEE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRPE7_ARATH
Sequence: MFLKVQLPWNVMIPAENMDAKGLMLKRAILVELLEAFASKKATKELGYYVAVTTLDKIGEGKIREHTGEVLFPVMFSGMTFKIFKGEIIHGVVHKVLKHGVFMRCGPIENVYLSYTKMPDYKYIPGENPIFMNEKTSRIQVETTVRVVVIGIKWMEVEREFQALASLEGDYLGPLSEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements.
What are the official names of this protein?
DNA-directed RNA polymerase V subunit 7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRF_BURPS
Sequence: MSVADIKKSVEQKMQRSIEAFKNDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANLTLVDARTIGVQPWEKTMVAKVEKAIREADLGLNPATSGDLIRVPMPPLTEERRRELTKVVKSEGETAKVAVRNLRRDANEQLKKLVKDKEISEDDERRASDDVQKLTDKHVAEIDKLVQAKDAEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM10B_BOVIN
Sequence: MDWKLEGSAQKTESRVLQEHEITLDDPGEDGVSESFQLLQIDVGCEHWEQETLPTGSAAWCSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRVENSGIYPQHSKRFLRSLIKERLLEAKHSGPRLCIDLSMTNHMSKKELSRLAGQIRRLYGSNKKADRPFWIYLTGFTTDSPLYEECLRMNDGFSSYLLDRTEEDCFSLFPLETLVYLTPDSDHALENVDLNKVYILGGLVDESIQKKVTFQKAQEHSVKTARLPIQEYMVKCQNGKNYHSEILTINQVFDILSTYFETQNWPEALKKGVSSRKGYVLRNSVE
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs.  Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
What are the official names of this protein?
tRNA methyltransferase 10 homolog B, RNA (guanine-9-)-methyltransferase domain-containing protein 3, tRNA (guanine(9)-N(1))-methyltransferase TRMT10B.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Protein: TRMB_YERPP
Sequence: MINDVISPEFDENGRALRRIRSFVRRQGRLTKGQQLALDSYWPVMGVEYQAAPVDLNTLFGREAPIVLEIGFGMGTSLVTMATNNPQQNFLGIEVHSPGVGACLSSAHDAGLSNLRIMCHDAVEVLENMIPEASLDMVQLFFPDPWHKARHNKRRIVQTPFVELVKSKLKVGGVFHMATDWQPYAEHMLEVMSGVSGYLNLSEQNDYVPRPDSRPLTKFELRGQRLGHGVWDLMFERKE
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: Y1396_METJA
Sequence: MKSYLKNISIFVFTILLLSNVSLGLNVSTTNNNSNFELNNSLIYKLNNSLTNTTNNSGSIIINNTTDTNKEKNECYLNITINGYRVIVKTNGEVFGFANKTPLKFIKIGDNEYIISPIVLNVPIEIYSKFNDKILHRTVILNYTKPEKEKKETNIKKEELHYLNVSFNNFKLIVKTNGKPYAKYLDLNIKVKTKKIKKHEYLVYPLILNKTIIIYAKFKNETLNRTIFLNYSIEENTTTNKTVILKNVYFPSEKIVIKTNFKPHTAYIVTPNNKIIHLKVHKKGKFYILSTKLKKNVILGNYSVVVDGIKKTFAVDYYKINAKLIDNRFIVGNVSYYVKEPKFITCIVDKKEINISLINGAFEIPLDYLIPKLNISKPEKIKKIILICGNAKEKIKVKFKNKEEIKKLISYDPVNKEIIIKLEGSEKEIKKLLKRYEKRKKYKISKIVKIYNYSIVEIKLKADKEILKDYNLPENILNTTEIVKKISSNKIRVEVNNKVDGVWYRFSCKIPKGYRVKEIVGDDGRVIRNNISINRLTGEVIGEVRWYIENNTLYFYDDPIYGYDISLIPPAPNHSIAVELSYNGQDYGGCGQISAIVFPYNKEDDETTVATYDHAGRTGDYNYANNIDAYAGSKIAIKYTSGALTRQYGVLGTAGSLGWWTYYYLSEINRTDIPLNTVPNGILESVIITDMYAPWNNNELNITQKVIIRGNNKWFATIYYIKNPTTKTYTNLKFFQGMDWNFRGSWWGDDAYYNSIDDVVYGYDSNAPVGDIQYGGFKSNIPSYEHDVNLYWSTWSDIRYDNLNNDSSYEGDAGTALAWTKDSLKPGEIWVVPIIWGLGYNYTDMMNEINMGLSQLYDTGVKSIDYPNNGDSFNPNIGPIIYINSTIALYGLVDAYNLNVSINITQINGTYIYTNSTLINLSVPYEEEKLVSFPVNISNMPYGAYNITIKTNLPNDQNTSNDEKSIIIYITSFSVQPNYQEKTGNVGEEIFYNITLYNFGVGGRFDINITYLTKGWTTKIYNNSILIAEDANGDGIWDYINPNYDLNSNNLPDIYVPTGEINLTVSKTIPSTAPLGEIDTTTLKFVNINNPSIFGKTTFQTSTPYPPSVQKTFYLHGDTLRTLNTSIPTTINNYTTINSNSLASWIQYPRFADNFTVVGKIPILLYINDPNVIFGTEMHKIVVSLMATNGIDSFTLGSDVEYLYLDDTIKSYIFNITLDSIITIPKNYYLVLRVENQISSNSINIYHNSTYPSNITLNTTTYVNVYNIFSDKNVYLPNENVTIFANITDPIGSYDISGANITVYYPNGSVYINSSMLLQEIDKNSPSLWKLYNYSFSLPESGKYLITITGIESNGVISKKNYTIYCGYEIQGYVKEDFGTLGKEDSEDKGIYGVNVSLLEDSNNDGIPDIGDTIVNSTTTDIFGHYSFLVYNSSKTYFVVVNSRTVGTTRGLNPQYSKNDIWAEETYQTVYTPINSSQWIANGNASIFPDKLLLTTDDYGEAGSVWYYKPVNLSEDLVVEFYAYLGDNPDGADGITFTLQSLGTNELGGTGGDLGYGGISPSVAVEVDTWLNDFDAPATTDHIAIDVNGNINHTYNSLTYPTPNPYDLGNVEDGREHLIKIVWNATTKTLQVYFDGNLSLTWNKDITQIIGNSAYFGFTGGTGGAKNLQYVKPIYVKNGDGYIINPTYGVVEMFGGRDPNEEDNWEDGKYEHYCLINLNSYSGKNITFGFSFDVITNTKSTGQGSFSQFIKNANAIYGKDESYFRIPNIDAKNGNHYIYTSGNKILDNLTIVNGSTQINGTIILSGLQWIANGNAYINNSNNLTLILTPDDYNQKGSVWYYKPVNLSEDLVVEFYAYLGDNPDGADGITFTLQSLGTNELGGTGGDLGYGGISPSVAVEVDTWLNDFDSPATTDHIAIDVDGNLNHTYNSLTYSTPNPYDLGNVEDGREHLIKIVWNATTKTLQVYFDGNLALTWNKDITQIIGNSTYFGFTGGTGGAKNLQYVKPTYVKNGDNVLNLEEISPNPIIDNVGADTYIGNIFFENVSVGILGNETGLNNLTLKSCGIYGKILNAGVKLVDYDWSLQNYPLYIDNLTINASGGYGISMLNKIWAMLYNSQISLKNGVGIYWANWAGGFGNITIYNITISSCNQGLVLYKDGNGIKLINSQIKNSVYEGVYSKNSTLEILNSSIINNSIGIYANISSILVNNSLIYKNRYEGLLLENSSSSILNSNIMNNSIGIYLKENYISKIQKSNISYNAYGIEIVNSSNVYINSSNIFNASTDGIAIFNGENVSVENSLLYNNNYSILSYGNLSNLSVLNSLLRDSINNSIDIEVPSDGFLNNLKLYNSSVLNSGSYGLFIYSLGSASNVNISKSLINGSYKDGIYIYGVNAINIVNNNITNNGLIGGDPAGSGIKISGNYTKGVLILNNNISHNLGNGISLEGLWSRTLCDVKVENNIISNNGIEENSGNGIYIGGRVENVSIFNNTIQYSDAQAILIQEANGWNSWDWIGTNISIINNTIQYNGLTVTIGNITAGITVGAYGVYNQDNGYIIIEGNKIINNNLCPNPTYGGKVGGIEVYGLNESWISLEFNISKNIIANNSAYGILIGASKDINIINNTIFNNEKGITIPNWDFVPYNIIISKNSIYNNSLLGIDLDDDNVTLNDGLLNYNEANHGIDYPIITYAELNGDNLTVKGYIGNGTGSSNFANAVVEIYLVKNLSGGDNLIGNNISSDGTVLNDTYGESWIYLGSLIADSNGFFSGTINVSGKGVGDESLLTATATIKGIGTSEFGRNYLLIKKFFNITGTIVMLPNGYNITIKSYNTTRDVYVYWYKPDNIEVINISGDYDENGTYGNTYWFKFNVINANETMNISITTNITTVEGLIIGIDPKK
What are the official names of this protein?
Uncharacterized protein MJ1396.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IF2_BUCAT
Sequence: MPDISLKVLSNEIKISIQELIKELSIIGITKTEDNYINVLEKNILLKHLESKKKYSLDTLVLQRKTRSTLRISTVGGKNKSVQVEVRKKRAYVKNNKFENESFLNEKKVIKHSMQKTSSLKNKEKKYIKNIEKIELNKSDSRSLNTKKENKLKISNKDEQNKKFNQHRESNSFDLNHKKRIKENKDIRISHKEEKQDYHLTTFLHARQAEDENDREVEIDKRNHGRILKNYRQKKNNKNFHNGRYNKEEIRTFNRNKKNSKQKNKPILLQQVFQKPESIINRDVIISNTITVSDLANKMAIKSSEVIKNMMNMGIIGTINHVLDQDTAQLIAEEMGHKVIVHRENALEELIMKDRDTGNDVSAIRAPVVTIMGHVDHGKTSLLDYIRSTKTAFYEAGGITQNIGAYHVKTDLGSITFLDTPGHSAFTAMRSRGVQITDIVILVVAADDGVMPQTIEAIQHAKEANVPVIVAINKIDKTDSDIDKVRNDLMKYNILSEEWGGENIFVSVSAKTGKGINKLLNVILLQAEMLELKAVTTGMAEGIVVESFLDKGRGPIATVLVKKGQLKKGDVILCGFEYGRIKSLRDASGNEVFSAGPSIPVEVLGLSKVPFSGDVVTVVRDEKKAREVASYRKEKSREKKLSNQNRINLENMFDDINKNNVSELKIILKSDVQGSLEAISGALLKLSTEEVKIKIIGLGIGGITETDASLALASNAIILGFNVRADTSAKKIINSEHLDLRYYSVIYDLLDEVKAAMTGLLSPEYKENIIGLAEVRNTFKSPKFGLIAGCMVTEGVIKRSNPIHILRNNIVIYEGELESLRRFKEDVNEIRNGLECGIGIKNYNDIRVGDIIEVFEVREMKRIL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUD16_XENLA
Sequence: MAESRSPDRGAKEDKPRPRNISREESLQLEGYKHACHALLHAPSQAKLFDRVPIRRVLLMMMRFDGRLGFPGGFVDTRDISLEEGLKRELEEELGPALATVEVTEDDYRSSQVREHPQKCVTHFYIKELKLEEIERIEAEAVNAKDHGLEVMGLIRVPLYTLRDRVGGLPAFLCNNFIGNSKSQLLYALRSLKLLREDQIQEVLKASHRLQY
What is the function of this protein?
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner.  Part of the U8 snoRNP complex that is required for the accumulation of mature 5. 8S and 28S rRNA.  Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA.  Catalyzes also the cleavage of the cap structure on mRNAs.  Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG).  Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies.  Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species.  Binds to the U8 snoRNA; metal is not required for RNA-binding.  May play a role in the regulation of snoRNAs and mRNAs degradation (PubMed:15053875, PubMed:10585477, PubMed:17567574, PubMed:18820299).  Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms.  The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP.  Binds strongly to GTP, ITP and XTP.  Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (By similarity). Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (By similarity).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
What are the official names of this protein?
U8 snoRNA-decapping enzyme, IDP phosphatase, IDPase, Inosine diphosphate phosphatase, Nucleoside diphosphate-linked moiety X motif 16, Nudix motif 16, U8 snoRNA-binding protein X29, m7GpppN-mRNA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NUDT16 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm.
Protein: MFNA_METBF
Sequence: MNEQGLSEKEIFSYLEDVKSEDTDYYRVLSSMCTHPHRIAVEAHRLFIEANLGDLGLFAGAHRLEKEVIRMLGELLHAQSVEIPSGEACESSVCGYLTTGGTESNIQAIRGMKNLVTEDGKKSGEILNIVVPESAHFSFDKVANMMGIEVKRASLDPEFRVDIASAESLIDANTIGLVGIAGNTEFGQVDPIEELSKLALENELFLHVDAAFGGFVIPFLEKPYSFDFKVPGVTSIAIDPHKMGLSTIPSGALLFRSPFFMDSLKVNTPYLTTKSQFTLTGTRSGASAAATYAVMKYLGREGYRKNVQYCMQLTTKLVKEARKFGFEPLIEPVMNVVDLRVPNPDIVREQLLKKFGWNVSITRNPRSLRLVLMPHNTARDIEEFLQDLRKVTTEL
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis.  Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
What are the official names of this protein?
Probable L-tyrosine/L-aspartate decarboxylase, TDC/ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: PUR7_STAA8
Sequence: MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ILVC_ACET2
Sequence: MAKIYYDSDCNLGLLKGKTVAIIGYGSQGHAHAQNLRDSGIDVVVGLPEGSKSRQKAVEDGLRVENTDVAAKMADVVMMLVPDQLQQDIYENSIKPNLEEGNVLAFAHGFAIHFKTIVPPPEVDVIMIAPKGPGHTVRSQYVEGKGVPSLIAVYQDASGKAKDYALAYAAGIGAGRAGILETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECIHEMKLIVDLINQGGFSYMRYSISDTAEYGDYITGKKIITEETRKAMKAVLKDIQDGVFASKWITENKAGGRAQFLAMRRNEAEHQLEKVGAELRKMMSWLKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CL2DR_RAT
Sequence: MPSSAHLQDPPPHLSRTLTQDEEQTSLRQSSSCGPSTTSASASESLSGSTKSRISQKKLLEGMLPKIIPTESAAKLLCCYAVFMALTVVVIALSIALSVKKTPQISAVNTYAACQRNWIGFGNKCYYFNETARNWTFSQTLCKEQEAELARFDNEEELNFLKRYKGSSGYWIGLHRESSADPWKWTDNTAYNNLVPIKGEEKHGFLSDNGLSSGKDYIKRKSICSKLNSYTSQCP
What is the function of this protein?
Lectin-type cell surface receptor.
What are the official names of this protein?
C-type lectin domain family 2 member D-related protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: CSRA_SERMA
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSADDLLIPKQRLVA
What is the function of this protein?
Involved in the process of swarming and quorum-sensing signal production; overexpression strongly inhibits swarming motility, pigment and N-acylhomoserine lactone (quorum-sensing signal) production but not swimming motility or swarmer cell differentiation (PubMed:11287746).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator, Repressor of secondary metabolites.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.