PharMolix/UniProtQA huggingface dataset:
Protein: FLHD_ECO5E
Sequence: MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITLLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_ECO27
Sequence: MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1595_METJA
Sequence: MMKIKITKSTILLIISFLFILAIMAYIGLDKIIKVLINTNPEYVILAFILQILVSVILSARWKFIIKILGYSANFKNIFLLVLMGLFINNITPSMRGGGEAFRAYYLSKLEEIPKGLAFSTVVVERVLDTAIFLFFTLFVIGYFVVTGFKYLEYLILSWIFLFSLTAIIIYLIANKGLLIKTVTKISKFICKYCSYNYDETKILQSIEEFYNSMKFFKNKRGWEVVVAIFLSVMRYIFDILKLWLLFLSLSYVVSVICVSAVYLITLLSGVLSITPSGFGTADTVMILSFSAFNIPPSVAAAVTLLDRLVSYILPTILGYIAMLIIKREIDKKKGK
What are the official names of this protein?
UPF0104 membrane protein MJ1595.
What is the protein family that this protein belongs to?
Belongs to the UPF0104 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIG_ACIAC
Sequence: MAVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGYSVQYEVLNDKVGEAFAQAANEANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDLSTADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPAEDGDRVTVDFEGKIDGETFSGGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVKKIEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKAELDLPNASVQAEIARLLEGARADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELVRANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRLAEVEAVVIENNVTAFVLDKAKVTEKAISFDELMGQG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: Y1170_THEAC
Sequence: MDVKPDRVIDARGSYCPGPLMELIKAYKQAKVGEVISVYSTDAGTKKDAPAWIQKSGQELVGVFDRNGYYEIVMKKVK
What are the official names of this protein?
Putative sulfur carrier protein Ta1170/Ta1414.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
Protein: EUTC_ESCF3
Sequence: MDQKQIEEIVRSVMASMGQAAPAPSEAKCATTTCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGELLGAKVVILLVGERPGLGQSESLSCYAVYSPCMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: PYRH_OLEA2
Sequence: MSELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRGLSSSAKGMDRSSADYMGMLATVLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAERHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIKATKVDGVYDKDPMQHDDAVMYRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS25_DICDI
Sequence: MSNQVFQFPPYYHKEPFFTIQPILNTRKKQFQMWQDLILQYCRYYKIYELDINESIKSNSVLFNNEKINRKLSREALKSIIDDIIENGFAEWVDKEKEKEKEKDKDNNNNNRVLIMWRKPDEWASLIYKWVADCGLLNTVLTVWEIQNGDDSKKQEFHQLNTTILMKSLKVLEKQSKCQTFSQDENVGVKFFSI
What is the function of this protein?
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
What are the official names of this protein?
Vacuolar protein-sorting-associated protein 25, ESCRT-II complex subunit VPS25.
What is the protein family that this protein belongs to?
Belongs to the VPS25 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_METPB
Sequence: MSRRHSAEKREIIPDAKYGDVVLTKFMNSIMYEGKKSTAERIVYGAFDLVESRARANPIEVFRAALDNVAPAIEVRSRRVGGATYQVPVEVRTERRQALAIRWLIQAARGRNDRTMVERLSAELLDAANNRGNAVKKREDTHRMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: BRE1_CRYNJ
Sequence: MNADLKRVRENTLDDSPSPSAKRRLNSNASSPIQPSDDEGMAEWMKIVEVKRKEAIYRQMLEYRRISEHETKRANDLEAQRRVLEASFHAVELCWTQIVAAVRDLAGAENLQLKEEEVLEPLLDPSTPVPELEKALRSRLPTTRQLVTRFVDLVAHNATRPASEADLQARCLKLEAEASALRSNSKLLESEISALKGSRDEAQRDLQRIRKALDRERMEHGKAQEEWKEERTRGGQATPNLRANGSGHSTPNGKVEADKKFYSGAGPSMAGVLQDTSELEQLAASRLKQLEQLRFEQTQLQQEVDRLKILANHPSEAALRESPFFQVYLHQLSTSINRAESLQTRFTATESKLDQLRDSNGEFREAVLAEARGQTETLRAQMAKKDSDIARLRGQRDELNSEIMERRAKEVEKCKYTEQIENLANSRQERISFLTSEVRRLKGKLAAAHSSDGYLSFLKESGIDGDYVKDLEAKVVTSQDQINALTSQLERVSSDTAAAKSETEVRTELESAKRLLARYERILGPNPEAAEDVRYLSQQLEKKEKERASLEMKLEEAEAATNALYSEVEGLSKLWEALDQTVKSKVLELRDGEQKITRLATEKAKADNKYFAAMRAKEAVDMEAKAAQRSVEKQLRLLERAQEVETSLRSQITANEKGLTALKNNALDLQNQLATVVAEKTQLELRLQQSQNALVEAQQIMHQRVAEAIAEKEARAKLQDEADGQMKIIKKLKERQDAVAAASQTGMSDHEWAITQERDKLLKLLKCSCCEQNFKQQVIVKCMHTFCKQCLEQRIASRQRKCPACGLAFAKEDIQTLYWQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1, RING-type E3 ubiquitin transferase BRE1.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZBT8B_MOUSE
Sequence: MEAQSYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRHSTASLDIVTSDAFSTILDFLYSGKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSLDICRKMEKEAAVAAAMAAAAAAAAAAAHQIDSESPSSGLEGTSCGTKSFVSSPVDGEGSLDCTISSCDDCHPLELVAKDSQGSGVSDNDLCVVPRRVEPKVEFDVARVEVEADEQLQQYAAPLAHMEEGLPSNQALDLTYSSYHVKQFLEALLRNGAVQSKDDLDCHSSRGLEGRLEGPGVAMSSVMDVQNDWYREDAGDVLVVPIKLHRCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSSRPIICKGCRRTFTSHLSQGLRRFGLCDSCTCVTDPQEEEDDLMPVNLSLVEASSESHEKSDTDDWPIYIESGEENDPTAEDSDDKPHIRPNLPAPETLT
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 8B.
What are the subcellular locations of this protein?
Nucleus.
Protein: URE1_BORBR
Sequence: MTRISRSAYAEIYGPTVVGGVGDRVRLADTLLLAEVEKDHTIFGEEVKFGGGKVIRDGMGQSQRLATDCVDTVITNALIIDAVTGIVKADIGIKDGLISGIGKAGNPDTQPGVTIIIGASTEVVAGEGLIVTAGAIDTHIHFICPQQIEEALATGTTTMIGGGTGPATGSLATTSTSGPWHMAAMLQALDTFPVNVGLFGKGSSSSHGALLEQVRAGAMGLKIHEDWASTPASIDTCLNVAEETDIQVAIHSDTLNESGFVEDTFAAFKGRTIHSFHTEGAGGGHAPDIIRAAGMPNVLPASTNPTMPFTRNTIDEHLDMVMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGAFSIMSSDSQAMGRVGEIVLRTWQTAHKMKLQRGPLQGDSERSDNERIKRYIAKYTINPAVAHGIAHLVGSVEVGKLADLVLWKPAFFGVKVNMVLKSGMAVSASIGDMGASISTPQPVQIRPMWGSHGKALRTSVAFVSQVSLSNPAVSELGLNKRLEAVRGCRGVTKHDMVRNNWLPAISVDPQTYQVYADGQLLRCEALAELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_HAHCH
Sequence: MLKVLGIDPGSRFTGYGVVEWGGGKPRYVASGCIRVTGETLAERLRCIYLGVTQVVSMYAPDEAAIEQVFMARNADSALKLGQARGVAILAMAEQGLQVAEYSAKKVKQSVVGKGNAEKWQVQHMMQAMLDLQAKPQADAADALAIAVCHLHTQQSLMRIGSVSSSRRGRMR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: DAPF_LISIN
Sequence: MATIHFTKVHGSQNDFFLVDEEENQIMDWSDAKRADFAIKLCDREHSLGGADGILYVTKSNEAGPIGQMRVVNSDGSIASMCGNGLRTVARYLLEKHALTEAKVETMKAILDVKKATSLGFDIPTYQVEISPVKFNAESLPMNVGVEKLFNQVVPELDSELAFSAVSVPNPHLITFVDQTVLDSDKQETLASYLNSENPYFPDGVNVSFVKRLSDDAIYVRTFERGVGFTNACGTAMSACSLIKKMLDKDTFETPLNVYNDGGRVQVTAKKDEAGEISLQLIGNATFVSTGSVSYERGTVTELTNEATPEQAQYQELVKEVKQFLKTTE
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_RALSO
Sequence: MSRVGKAPIALPKGAEVNFAGGLLTVKGPLGTLTQAIHNLVKVVIDNGTITFSPADESREANALQGTMRALVANMVKGVTTGFERKLTLVGVGYRASLQGAALKLQLGFSHDVIHEMPEGVKAETPTQTEIIIKGSDKQKVGQVAAEVRGYRPPEPYKGKGVRYANERVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SPN90_HUMAN
Sequence: MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS
What is the function of this protein?
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1).  Induces microspike formation, in vivo (By similarity).  In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity).  May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres.  Implicated in regulation of actin polymerization and cell adhesion.  Plays a role in angiogenesis.
What are the official names of this protein?
NCK-interacting protein with SH3 domain, 54 kDa VacA-interacting protein, 54 kDa vimentin-interacting protein, VIP54, 90 kDa SH3 protein interacting with Nck, AF3p21, Dia-interacting protein 1, DIP-1, Diaphanous protein-interacting protein, SH3 adapter protein SPIN90, WASP-interacting SH3-domain protein, WISH, Wiskott-Aldrich syndrome protein-interacting protein.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Protein: MTNA_XYLFA
Sequence: MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRALIVRGAPAIGIVAGWGAVLAAREIEAVDGIEALRKLEPALQRLHAARPTAVNLAWVLARMRRTLSAAHADWRQAMAREAESIAREDLTANRCMGAYGAALIPIGSGVLTHCNTGSLATAGFGTALGVIRAGIAQGRIARVFAGETRPWLQGARLTVWELQQDGIDVTLIADSAAAHLMKSGQVQWVIVGADRICANGDAANKIGTYQLAITARHHGVKFMVVASAATVDMDTTAGEAIEIEQRDPEELLGVSGVRTVAEGIAAWNPVFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: RS4_SULAC
Sequence: MGDPRKSKKKWMGPSHPWIKINLGKEQILIGKYGLRNKKEIWIAQTMIRNFRHQARSLLALPPAERNIREKQLIQKLYRMGILEKDNSTLDDILSLTEENYLERRLQTIVYKKGLARTIYQARQLITHGHIAISGRKVTSPGYVVLRGEEDLIDYYPTSPFKQNPPSQGEVNVEQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RTCA_ECOLC
Sequence: MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SETB2_XENLA
Sequence: MEQSANARQSTLRSRTQELNTLSVLSKDVSLEDAKKYWKDRQADGKVDWIFEKVLNKLKILWQKIKDGSATNLEYVRAVILVNEAGNLEEDLEEDLKEDTDTIHIDIHKENEVQENTDCSPERKEDTCLNLNTDCGTDVSGSEPECNSTVSPPAAERVYFGNHSCGPSCLSGINSFLFTKGNPLQLPISCDFQRCHLKINSPDDLSHILYKAPCGRSLRDYDEVHSYLTETGCHFLAVDNFSFNNHVRLDSNSSFNQGIVQDCDISNDVESVPVAFSNEIDNTRPSNFIYRKTSWPPGYSLNNFTDIFVKCCNCTDGCLDILTCSCLQLTAQAFTKCMESSLGIGPLGYKHKRLQEPIPTGLYECNVSCKCDRMLCQNRVVQHGLKLRLQVFKTNTKGWGVRCLDDVDKGTFVCIYAGRILIRTADCTVKSTPDDSVACGNEDHEDSTSTCALILSKRKRKTSHSDSEVTVMHTNPYSMRSHGLSVHRLSNTFSPRQARSGEREFSLQPLRRPKTKTSMLQKRRRQLIEEGACTVQNSSEEEGPTPPQSPEQKSSAGTKIQRNENSDETASGYVSEESSSSVISGGHPLEKPISKFKSKLNKTTVYLSTSPEQTCEENLHFLDASKEGNVGRFLNHSCCPNLFVQQVFVDTHQKCFPWVAFFTNSVVKAGTELTWDYSYDIGTAADQEIQCLCGQKTCKNKVV
What is the function of this protein?
Histone methyltransferase involved in left-right axis specification in early development and mitosis.  Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3).  H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats.  Plays a role in chromosome condensation and segregation during mitosis (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase SETDB2, Chronic lymphocytic leukemia deletion region gene 8 protein homolog, SET domain bifurcated 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DPO4_LISMC
Sequence: MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMAHYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKKPAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPHRDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAALLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_RICAE
Sequence: MHKYQTHWVEHSIVKILSSTGKKHIALMVGGMSAEREVSLVSSEGVSKALIELGYRVTFIDMGADIAVRLQEIKPDIVFNCLHGTYGEDGCLPGLLNIMRIPYTHSGMLSSALAFDKIHSRIWFLTNNINMAESIVVNKSDNIKNDPMKRPYVIKPLTQGSSIGVEVIFAEDDFNFADYDFPYGDQVIIEQYIKGRELQVAVLNGKALGALEIKLLKNRFYDYETKYTEGFADHLCPAPLPANLYEKLLIESEKIYKTMNCKGPARAEFILEEQTNKLYALEINTHPGMTPLSIVPEIAAYAGINFTNLIEEIIKMASFES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU3M_PANPA
Sequence: MNFVLILMTNTLLALLLMIITFWLPQLNSYMEKSNPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTANLPLMVMSSLLLITILALSLAYEWLQKGLDWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TI11D_ORYSJ
Sequence: MAAAGSSSRFAVTCGLLSQYMRERQQPQPPVTVLEAVAEEEEEEDARTMQLFPPRAAAADGVATPSAGTAPLTIFYDGRMVVVDDVPVEKAAELMRLAGSACSPPQPAHAAALPEMPIARKASLQRFLQKRKHRITTTSEPYKKAAVASPAPEKSFAVAPVKDEPATWLGL
What is the function of this protein?
Repressor of jasmonate (JA) responses (By similarity).  May act on an initial response of JA-regulated gene expression toward drought tolerance as part of a BHLH148-TIFY11D/JAZ12-COI1A complex (PubMed:21332845).
What are the official names of this protein?
Protein TIFY 11d, OsTIFY11d, Jasmonate ZIM domain-containing protein 12, OsJAZ12, OsJAZ1.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUFU_MOUSE
Sequence: MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
What is the function of this protein?
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:16155214, PubMed:16459298).  Down-regulates GLI1-mediated transactivation of target genes (PubMed:11960000).  Part of a corepressor complex that acts on DNA-bound GLI1 (PubMed:11960000).  May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity).  Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10531011, PubMed:16459298).  Negative regulator of beta-catenin signaling (PubMed:11477086).  Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:10531011, PubMed:20360384).  GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:10531011, PubMed:20360384).  Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:10531011, PubMed:20360384).  When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:10531011, PubMed:20360384).  Required for normal embryonic development (PubMed:16155214, PubMed:16459298).  Required for the proper formation of hair follicles and the control of epidermal differentiation (PubMed:16155214, PubMed:16459298, PubMed:23034632).
What are the official names of this protein?
Suppressor of fused homolog.
What is the protein family that this protein belongs to?
Belongs to the SUFU family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.