PharMolix/UniProtQA huggingface dataset:
Protein: RL16_RIPO1
Sequence: MLSPRRTKFRKQQRGRMRGMAYRGSTINFGDYALQATEPCWITSRQIEAARRAMTRYIKRGGKIWIRIFPDKPVTMRPAETRMGSGKGSPEYWVAVVKPGRIMFELDGVSEPIAREAMRLAAQKLPIKTKFITKAEEYI
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: AAC2_PROST
Sequence: MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW
What is the function of this protein?
Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides.  It confers resistance to aminoglycosides.
What are the official names of this protein?
Aminoglycoside 2'-N-acetyltransferase, AAC(2')-Ia.
What is the protein family that this protein belongs to?
Belongs to the AAC(2')-I acetyltransferase family.
Protein: BAME_HAEIN
Sequence: MQVKTLLGATFLALSLASCSTVEKVVYRIDVPQGNYLEATTVAQVKEGMTAQQVQYLLGTPVLVDPYNSQTWYYVFLQQRAYETPVQHTFTVKFDQRGIVTETHLDKPLPQVSQQGENNTIIETGEKPKSSWWKFWK
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamE.
What is the protein family that this protein belongs to?
Belongs to the BamE family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: THII_METJA
Sequence: MKKLKVSKMEILVRYGEIGLKSDPIRKNLEEILRKNIIKLLRKYEIDAEVKILHRKLLVKINTKDKEDLALKLLKKVAGIVSYSPVYECPLDINEIVSFAVQIMKKKLKTLNKEKVTFAVKTKRSYKKFPFTSVEVNKKVGEAIVEKLGLEVDLENPDIVLGIEILNDGAYIFTEKYEGIGGLPAGSQGKVLCLISDGIDSPVAAFMMIRRGCRAVLLHLKMSEEALNKVRKIVEVLSDYDTELEFVVYDYKKDIEDIVEKLKSIKKENYTCIFCKRKMLKVAEKYAKYLDCDAIVTGDNLGQVASQTLKNLRVISENINYPILRPLIGLDKNDIVKIAKEIGTYEISTEKEIKCPYLPKHPKTIAKPEEVKKIKEKVKLV
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMDH_CRYNJ
Sequence: MADTNPNAPPRSDSLLNPADALKYLEEYPRGDGLSLQELMDSRKNGGLTYNDFLVLPGHISFPASDVSLQSRATKNIVLNTPFLSSPMDTVTEDRMAIALALHGGLGIIHHNCSAEEQAAMVRRVKKYENGFITDPLCLGPDATVGDVLEIKAKFGFCGVPITETGAPNSKLLGIVTGRDVQFQDAETPIKSVMTTEVVTGSSPITLEKANSLLRETKKGKLPIVDSNGHLVSLVARSDLLKNQNYPYASKVPESKQLYCGAAIGTRPGDKDRLKLLAEAGLDVVVLDSSQGDSVYQIEFIKWIKQTYPKIEIIAGNVVTREQAAQLIAAGADGLRIGMGSGSICITQEVMAVGRPQGTAVYAVAEFASRFGIPCIADGGIGNIGHIAKALALGASAVMMGGLLAGTTESPGEYFYHEGKRVKVYRGMGSIEAMEHTQRGSASGKRSILNLDNAATARYFSEADAVKVAQGVSGDVADKGSINKFVPYLFTGLQHSFQDAGVKSVSELHSCARSGSLRFELRTASAQLEGGVHGLNSYTKRLFA
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM26_XENLA
Sequence: MIIEDFEALKHWLSKTLEPICDADPSALAKYVLALVKKDKSDRELNALCIDQLDVFLQKETQGFVDKLFDAINTKSYLPQPDSTSTAVVKLDSFEHQEKEIKKDEVNKEEEKEKKAPRRLNQSPQPSSTRHKDTRENRKRSNSDRESNSIQNSFRSGLPEQKQDVDAAPPRLNSNKVQNAKNTRSRDDRKRDDRFRKREYDRNVPRRDSYRDRYNRRRGRSRSYSRSRSRSWSKERQRDRDRSRSRTRSRDKDSGKPKFDLDRPDPVDNSYASGSSVPHIGSAHFPVPTLSSTITVITPSHHGNSSAENWPEFHEDQVDHSSYGRLQMQKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPGILPFPAPPPVLEGPPPPGLPPPPSLLTPPPVNLQPPPVPPPGPLPPSLPPVTGPPPPLPPLQPAGMDAPPNSATSSVPTVVTTGILHPPPVPPSSLFPSAAAAAGPIPLFPETYEADGYNPEAPSMTTTSRPLYRHRVHAQRPNLIGLTSGDMDLPTPREKNNMRIVVDSESRKRNLGSGDCVLPSKKPWFDKSNFNNRMNPGFQKKPLFPNENTKLELRRIPPELNNISKLNEHFSKFGTIVNLQVAYKGDPEGALIQFATHGEAKKAISSTEAVLNNRFIRMYWHREGSSQQLQTPGLPKVVHLTVPQQPNLSVMKQSIKERLGPVPANNSEPSVAQNINTETTQNIAKVPVKERLGYMSKTVSAATEKVFSTSTGLTKTVYNPAALKAMQKSVLYPICNDNGDAQKKKQEALKLQQDVRKKKQEILEKRIETQKILISKLEKNKNMKSEDKAEILKTLETLTNSITKLRDELKAVSSTGNVVKNNKSKAQMQKELLDTELDLYNKIQAGDDVTELRKKYTELQLDAAKRGILSSGRGRGVHLRGRGVIRGRGRVLHGRGRGASVHAVVDHRPRALKISGFTEGDREYLLPHFAHFGEIEDCQIDDSSLHAIITFKTRAEAEAAAVHGAQFKGQDLKLAWNKPVPNASSTEVEDADQEEEEFHEDSIVDDSLLQDDDEEEEDDNESRSWRR
What are the official names of this protein?
RNA-binding protein 26, RNA-binding motif protein 26.
Protein: R27A2_ENTH1
Sequence: MATRFRQTRRRRGHVSMGYGRIGKHRKQRGGRGNAGGQHHRKTWFTTFHPDYFGKHGMRVFHLKANKYYCPSINVDSLWSLVGKDVQAQYKNAKVGEEVPVIDCVKHGYFKVLGKGFLPKQPVIVRARYFSEKAQQKIKAVGGACELTA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L27a-2/4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DNLI4_ORYSJ
Sequence: MAATVRFGLLVAMFQAMSRDRTAAKKRARLRALLDRAYGPGGRDDYFSALRLVLPGLDRERGSYGLKEAALASVLVDALGIAKDSPDAVRLTNWRRGGGFRNAGNFALVAAEVLQRRQGMTSGGLTIKEVNDALDRLAATENSVCLESEKLLLILDRSEKASILSSLIKKTNALEMKWLLMIILKDLKLGISEKSVFHEFHPDAEDLFNVTCDLRLVCEKLNDRSQRHKRQDIEVGKAVRPQLSMRVNNASSAWKKLHGKQVVAECKFDGDRIQIHKNGEEIHFFSRSFLDHSEYAPGMSKVIIENILVDRCILDGEMLVWDTVLNRFAEFGSNQEIAKAAKEGLETDRQLCCILEWIASYVLALCVNILSCQDFFFSNKRESYVAFDILYAGDTSVIHQSLTERHEILQKVVRPLKGHLEILVPTGGLNIHRPPDEPCWSILAHSLDDVEKFFKDTVDNRFFPTSPNTDELSNLSISLMIQFRFSDYSICYVLREEGIILKDLESKWEPGDRSGKWLKLKPDYIHAGADLDVIIIGGYYGSGRRGGEVAQFLVGLAVPSDDNSYPKRFLSFCRVGTGLSDEELDALVTKLKPHFRKNEYPKKPPRFYEVTNHSKERPDVWIESPDKQSVRFRKHLIYCITKCRSVIISITSDIRTIKSEVFAAPYSLRFPRIQRLRYDKPWHECLDVQAFVDIVHSSNGTTHRAADDDNDLKNVKNGGSFSMNLNDSVTHCIAAEKKATRQGRIIHYSWILDCCKEKRLLHLQPKFDPCLQPMHKFPEEIDSYADYFYWDIDISDLKQIFSNMDRAVVDSNMVHHYKKKYCADERFCFFQGCCVYFYHAPLVNADYNVISDLALKRVKQDLTMHGGQVCSILAPATHLIIVSVLQAYNFDMLYKSLPPAERRYLHDKRLQVVSNKWLEDSVEKQTRLPETTYSLKPDTLEEIEIERSEETVQPCNDKLEENEKADTSHVKHAPRKRGRPSSSASRTAKPAPRPVRRTRARRGNQHAKIDDVEPEESDHGETGLDDQIPDTDNISKMEVDSFDKDQVSARPVRRTRARRGKQHAKIDYGQSEESDPGETGQDDQRLDADYISKMEEDSSDRDQGAHPTAPRVVRRSRAQRGKWLAKIDRETGPGETGQDDKKLNADSISKMEEHAHDKDQEPPPGAQLITLDEQEPKGIKSSTTETPSSPKHERNQTVLRRDTAETTSSATCEKMEQMVDPLHAMLLDMIPSLGQMKTDVGNRVAEAKAETNPPWVGSSTSSYVAPVPQASASSASSSGVPAPHAGSSTQSTGVPAPDPTAGAPKKKKVSYKDVAGALLKDW
What are the official names of this protein?
Putative DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPTD_PSE14
Sequence: MALKSPAFRKKFPLLVTGSLLAMQPLATQFVVAAEQYDCSVSASGAWNCAPKSNAAAVDLPPRPVHDTTSVSSNGTVTSQSTSSGEQVAGTQLVTEAKGKGLRSRSADYSHLDWVPREKLTAAQLAETGPYCSGAYVEPIRPGMDDKTPMKDAPMFVGAKASRYEQEAQVATLAGDVVLRQGSMQVQAQEAALHQAENRGELNGDVRLRDNGALIVGDKAELQLDTGEARVDNAEYVLHKSNIRGNALYAKRAENAIIRLKDGTYTTCEPNSNAWTLKGNNITLNPATGFGTATNVTLRVKDIPVLYTPYIYFPIDDRRQSGFLPPTIAAGGDNGFTLVTPYYFNLAPNYDATLYPRYMADRGLLMEGEFRYLTKGSEGQFGGAYLNDENDDRKLQSDYDKTRWMINWQHKGGLDTRWLTQVDYTDISDPYYFQDLETDQIGVKRTDFLNQQGSLTYRGDSYAATLNAQAYKLATVANITPYNRLPQLTLNGTLPYNPGGLKFDYQTEAVRFERDLRSGAFIDEDGNSETRLDNNISGLARANGDRLNLAPSVSLPMNWTYGFLTPKLKYVYTQYALDLDSQGKSSLLAGEEYSSSQSRSVPIFSVDSGLYFDRNTNWFGKDYRQTLEPRLFYLYVPEKDQTDIPVFDTSESTFNYASLFRDNRFTGSDRIGDENKLSLGITNRWIEDNGFERQRFSIGQALYFEDRKVQLPGVVFADRDDARANVSPYALEYEYRFNRDWRFNSDFNWDPDSKSTRSGSAMFHYQPEDNPNKIVNLGYRYRNDQIRYDESTGRWIVGGGDYGRPGDANYVKDYYKIQQHDFSVIWPIVPQWSLISRWQYDYNRERTIEAFGGFEYDNCCWKMRLVNRYWVDYDEFSQAAPQNEKGDRGIFLQIVLKGLGGVTGAKVDSFLDKGIQGYREREDQAF
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: KITH_ASFK5
Sequence: MSLIRKLKPGTISLVLGPMFAGKTTFLIHCINMLERLEKKVVFIKSTKNTRDKTIQTHSGIQLRPNQCKIIESAQLSDVGSLTDTHAVVIDEAHFFDDLIRCRTWADEKKIIILAGLNASFEQKMFQPIVRIFPYCNWVKYIGRTCMKCNRHNACFNVRKNADKTLILAGGSELYITCCNNCLKK
What is the function of this protein?
Phosphorylates thymidine.  ASFV replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including thymidine kinase.  Important for growth in swine macrophages in vitro and is a virus virulence factor in swine (By similarity).
What are the official names of this protein?
Thymidine kinase, TDK.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
Protein: RT31_BOVIN
Sequence: MFPRVSAVLPFRPLSRLPLCSAGPEASAATVVPLASPHGTVRTKCNIQRYFGTNSVIYSKKDDKSVPACEISKETENQGSTKENKKKDLVNIIKGMKVELSTVNVQTTKPPNRGQLKSLEAAIRRLQKSPEDAPQKSKSLSPELVAAATAVADSLPFDKQTTKSELLRQLRQHEEDSKAQKDGEKPKISFSNIISDMKVARSSTARASTRPVHQIQFDEGADDFVDREETADLRKRFRKNIFKGKRLNIFELKPVTEEAPETEAAPSLWDVEFAKQLAAVTEQPFQNGFEEMIQWTKEGKLWEFPINNEAGFDDDGSEFHEHIFLDKYLEGFPKQGPIRHFMELVTCGLSKNPYLSVKQKVEHIEWFRNYFNEKQDILKESGINFS
What are the official names of this protein?
28S ribosomal protein S31, mitochondrial, MRP-S31, S31mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS31 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DEOB_VIBCM
Sequence: MKRAFILVLDSFGIGATADAQAFGDVGSDTLGHIADQCAQGLADNAERKGALQLPNLSKLGLAMAHKESTGRFAPGLDERADIIGAYAHAAELSSGKDTPSGHWEIAGVPVLFEWGYFSDKQNSFPKELTDRILARAGLDGFLGNCHASGTQVLDDLGEEHMRTGKPIFYTSADSVFQIACHEETFGLARLLELCQIAREELADYNIGRVIARPFVGPGKGQFARTGNRRDLSVEPPSATVLQKLVEEKQGRVVSIGKIADIYAYCGITDKVKATGIPDLFEATLEQIKQAGDNTIVFTNFVDFDSAYGHRRDVAGYAAALEYFDKRLPEVLALMQEDDILILTADHGCDPTWPGTDHTREHIPVLVYGKKVAPGSLGRRDTFADIGQTLASYFGTSPMDYGKNFL
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORN_HAHCH
Sequence: MSRRDNLIWIDLEMTGLDPDSDRIIEMAVVVTTSNLELVAEGPVIAVHQPDSVLALMDDWNRNTHGASGLTGRVKGSTIGEADAEKQILDFLAQHVDAGCSPMCGNSIGQDRRFLARYMKDLEKFFHYRNLDVSTLKELARRWRPEVAAGIKKKGSHQALEDIRESVEELRYYREHFLRLTD
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_MOUSE
Sequence: MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGPEGERPARFTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
What is the function of this protein?
Component of the 40S ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
40S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus (By similarity).
Protein: RL22_CAMJD
Sequence: MSKALIKFIRLSPTKARLIAREVQGMNAELAMASLKFMPNKGAKYIANAISSAVANGGFEANEVIVKSCRVDVAAVLKRFRPRARGSASRIRKPTSHILVEVVKAEVKAEEKKTVAKKTTTTKAPAKKTTSTKKATAKKES
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PNP_BUCCC
Sequence: MLKPIIHKFKYGKHNIILETGVIARQATASVLASMDDTTVLITIVSDNTTIPGQKFFPLVVNYQERTYAAGRIPGGFFRREGRPSENEILISRLIDRPIRPLFPKDFLYEVQIIATVISVNPQINPDIISIIGSSAALCLSGLPFLGPIGAARIGFLNNKYILNPSIEKIKKSSLDLVVSGTKNTIFMVEAEASILSEDNILNAILFGHESQQSLIDNIYLFSDKANKIPNIYKNIYKPDKQIFNLISKKIKKDINKAYYILKKKERLKKLNDIKQKVTSELLNNDSQLTSSKIEESIYFLERNIVRKRILKGKLRIDGRINNEVRKIDVRTGILPRVHGSALFTRGETQALVSATLGTSRDAQNLDDLLGDRTDNFLFHYNFPPYSVGEIGIVGSPKRREIGHGKLAKRSFLAVMPNIEDFPYTIRLVSEITESNGSSSMASVCGASLALMDAGVPIKSAIAGIAMGLIKENDSYIILSDILGDEDYLGDMDFKVSGSRLGITALQMDIKVSGITSDIIRSALYQAKSARLKILDIMENTLQIPRSDISKFAPRIYTIKINPEKIKDVIGKGGSIIRMLTEETGTVIEIKDDGIVKISAINGEKAKYAIKRIQEITEDIQIGKIYSGKVTRILDFGAFVSIGFGKEGLIHISQISNKRIDKVINHLKINQIIFVKVLEVDRQGRIRLSMKNI
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN4_RAT
Sequence: MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKVQPRVISFEEQVASIRQRLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4, JAB1-containing signalosome subunit 4.
What is the protein family that this protein belongs to?
Belongs to the CSN4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein: TRPA_XYLFT
Sequence: MHRIDETFRRLRAQSRKALIPFITAGDPSLEAAVPVMHALVRAGADVIELGVPFSDPMADGPVIQHSSERALQRGVGLAYVLQTVDVFRQSDAVTPVVLMGYLNPLEIYGIARFTQQALASGVDGVLLVDLPPEEADEIRAIFSAAGLALIVLASPTTSASRLATLSGVAQGYLYYVSFAGVTGADRLDAQSAGDRLRGLRAQTQVPVVVGFGIRDAASAVVMAVDADGVVVGSALVTALSDAPDVDTACRRADAFLAPLRQALDAVK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PDE1B_MOUSE
Sequence: MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSFRATWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD
What is the function of this protein?
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.  Has a preference for cGMP as a substrate.
What are the official names of this protein?
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 63 kDa Cam-PDE.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FIBB_RAT
Sequence: MRHLWLLLLSVSLVQTQAATTDSDKVDLSIARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKVDAGQKKVERKPPDAGGCVHGDGDMGVLCPTGCELRQTLLNHERPIKNSIAELNSNINSVSETSSVTFQYLTLLKDMWKKKQAQVKDNENVINEYSSILEDQKLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQTEYCHTPCTVNCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSSKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDTKKYCGLPGEYWLGNDKISQLTRIGPTELLIEMEDWKGDKVKAHYGGFTVQTEANKYQVSVNKYKGTAGNALMEGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPVFPQQ
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain, Liver regeneration-related protein LRRG036/LRRG043/LRRG189.
What are the subcellular locations of this protein?
Secreted.
Protein: DYR_SHIFL
Sequence: MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: DNAK_THEYD
Sequence: MGKAIGIDLGTTNSVVAVVVGGEPVVIPNQEGQRTTPSVVAFTDKGERLVGQVAKRQAITNPENTIFSIKRLMGRKYNSQEVQEAKKRLPYKIVEAPNGDAHVEIMGKRYSPPEISAMILQKLKQAAEDYLGEPVTEAVITVPAYFDDSQRQATKDAGRIAGLNVLRIINEPTAAALAYGLDKKKEEKIAVYDLGGGTFDISILEIGEGVIEVKATNGDTYLGGDDFDIRVMDWLIEEFKKQEGIDLRKDRMALQRLKEAAERAKIELSSAMETEINLPFITADASGPKHLLMKLTRAKLEQLVDDLIQKSLEPCKKALSDAGLSQSQIDEVILVGGQTRTPKVQKVVQDFFGKEPHKGVNPDEVVAVGAAIQAAILKGEVKEVLLLDVTPLSLGIETLGGVFTKIIERNTTIPTKKSQIFTTAADNQTAVTIKVYQGEREMAADNKLLGVFELVGIPPAPRGIPQIEVTFDIDANGILHVSAKDLATGKEQSIRITASSGLSEEEIKKMIREAEAHAEEDRRKKQIAEARNEADNMIYTVEKTLRDMGDRISEDERKRIEEAIEKCRRIKDTSNDVNEIKAAVEELAKASHRVAEELYKKAGASQQGAGSTTQSKKEEDVIEAEVEDKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: UVRB_MYCPN
Sequence: MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQLPTVVIAHNKTLAGQLYQELKELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNEEIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQYSLWLVVGKEYGLSELKTQLIHLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLETLNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADLKAWGVCSGVENYARHLEHRPPHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDISRKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATPREEEIQLSHNNVVEQLVRPTYLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYIHKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLIQIIGRAARNVHGRVIMYANTISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLNQPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEIRDSIFELEKQFRGKIKS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMN1_HYPEX
Sequence: MAEKAGEAGVQTRSRRNRSTSREVSNGVAAPPAKATRSSQLEAVAEQATPSSQQSQKSVRTESSMSLGFNGGSSQGSRATSPTSFSRAQEKEELQNLNDRLAKILNKLNDSEEENRTLKIRLTTVQQETSADLNDQIGKYRDELERARKAVDAITQEKDRELLAKDKALGELNEHKAQFAALRKRLDELEARLKAAEKAARDKDNVLTELKAQLAESETAGKRIQKELADKTKQLDQARNQIEQEVISRTNLENALKTAEEKAKFENNLLESKLQRQSLSVTTVDHHSAQSTSRRSGSDFSASVEDMRSALEDAREEIQENMDRMYGSKLEGLEVLSESQKQTINGLNQALTASRHDMKDLQKENQQLRKKVGEVEKELHQQHQKFDQHKMDCTARIAALSDQSNQASQQYQALLEEYRTTTHNNVEMRTELEMYNKLLSDEEIRLGITSADQYGGVRHGAKKRKLTETFYTTPFGSRSSAGSRSAGHNSTPVTKSQVTRTTVKTSENKSKASGPVRILEVAPGKVVRLENISEAVMQLGHWRIHQHGASGDAAFQFEKDQVIGGQSIISVYSSTEDSQPNNGVTEIIATNAWLADSHLETVLSDGDGNQMATYEVSADSNLDIHNDSVRDSPRSAGKGILGFFGL
What is the function of this protein?
Intermediate filament (IF) protein, component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope (PubMed:26840051).
What are the official names of this protein?
Lamin-1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.