PharMolix/UniProtQA huggingface dataset:
Protein: RPO2C_METVS
Sequence: MEKQANVYVNGKLIDTSKDPENLVKSLRIQRRSGKLSPNTSISFNEESNDIHISTDGGRAVRPLVVVENGFSKLTNELLEKVNNNELTFEYLVKTGVIEFLDAEEEENARIAMYNDEITFENTHVEIDPLVILGIGAGVAPYPEHNSAPRITMAAAMGKQSLGIPMANIKWRMDTRGHLLHYPQVPLVRTKHQEILGFDKRPAGQNFVVAVMSYEGYNMEDAFVINKASLERGLGRSTFFRSYESFEKRYPGGQLDKFEVPEKGVRGYRAEEAYRNLGDDGLIDLESEVRSGDVILGKTSPPRFLEEQEITLQTKSQRRDTSVTIRHGEEGVVDLVILSETKEGNRLGKVRVRDLRVPEFGDKFASRHGQKGVIGLVVPQEDLPFTEDGVIPDLIINPHAIPSRMTIGQVLEMIGGKVGSLECRRVDGTIFSGEGEWALRHALENYGFTHSGKETMYDGKTGRKLECEIFVGVAYYQKLHHLVAGKIHARSRGPIQVLTRQPTEGRAREGGLRFGEMERDVLVAHGAALLLKERLLDESDPHEDYVCAKCGEIAIFDYKRGMKFCPVCGESEDIQDNRKIPPVKIAYAFKLLLDELKSMGIDPKLKLKDRA
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo2C, DNA-directed RNA polymerase subunit B'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_KORCO
Sequence: MSTERKGKIGVAHIYSSFNDTIVHITDITGAETLARYSGGMFVDADRLEGSPYAALKAAMAAAKEAQRKGITHLIVKVRAPGGIKSRIPGPGATAAIRGLSRSQLTLIRVEDVTPIPHDGCRRPHGRRGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: AGP10_ARATH
Sequence: MASKSVVVLLFLALIASSAIAQAPGPAPTRSPLPSPAQPPRTAAPTPSITPTPTPTPSATPTAAPVSPPAGSPLPSSASPPAPPTSLTPDGAPVAGPTGSTPVDNNNAATLAAGSLAGFVFVASLLL
What is the function of this protein?
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
What are the official names of this protein?
Classical arabinogalactan protein 10.
What is the protein family that this protein belongs to?
Belongs to the classical AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: PG143_VACCC
Sequence: MGAAVTLNRIKIAPGIADIRDKYMELGFNYPEYNRAVKFAEESYTYYYETSPGEIKPKFCLIDGMSIDHCSSFIVPEFAKQYVLIHGEPCSSFKFRPGSLIYYQNEVTPEYIKDLKHATDYIASGQRCHFIKKDYLLGDSDSVAKCCSKTNTKHCPKIFNNNYKTEHCDDFMTGFCRNDPGNPNCLEWLRAKRKPAMSTYSDICSKHMDARYCSEFIRIIRPDYFTFGDTALYVFCNDHKGNRNCWCANYPKSNSGDKYLGPRVCWLHECTDESRDRKWLYYNQDVQRTRCKYVGCTINVNSLALKNSQAELTSNCTRTTSAVGDVHHPGEPVVKDKIKLPTWLGAAITLVVISVIFYFISIYSRPKIKTNDINVRRR
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
Virion membrane protein OPG143.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG143 family.
Protein: CAH12_HUMAN
Sequence: MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 12, Carbonate dehydratase XII, Carbonic anhydrase XII, CA-XII, Tumor antigen HOM-RCC-3.1.3.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein: BIRC3_MOUSE
Sequence: MVQDSAFLAKLMKSADTFELKYDFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSDPVNFRANQDCPALSTSPYHFAMNTEKARLLTYETWPLSFLSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFLKDLGQSASRYTVSNLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLLSTSDSPEDENADAAIVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQWQILATGENYRTVSDLVIGLLDAEDEMREEQMEQAAEEEESDDLALIRKNKMVLFQHLTCVTPMLYCLLSARAITEQECNAVKQKPHTLQASTLIDTVLAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDDIAALPMEEQLRKLQEERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis.  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.  The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10.  Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 3, Cellular inhibitor of apoptosis 2, C-IAP2, Inhibitor of apoptosis protein 1, mIAP1, RING-type E3 ubiquitin transferase BIRC3.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRIS_METS3
Sequence: MFSKATLKERRQYYREEWSTKDMPDFILKDLKKREFGFDHNGKGPNDRYKVFRGSESLKKFLRYKAPFAAYISVAFYNNPRRREDWQKAEYIFDVDAKDIPIRSCQCDGVCEVCLGQALEIVNSLIDTLQDDLGLNNIHLVYSGRGYHIRILDEEMMTSGSELRSEVLKYVAGAEVPKSNFFNPDISNKSFNFEHFSIPVGYSKIFTDKLKYNIQHLVGNEELDEINPKLMKDIIKYRHHLDNDNWGYFKRDIGPRRYKNLTEAMARVNLSTIDAKVSIDLKRILRLPSSLHSKVSMKCMEVKNRETFDPLQEAVPKFVEERGE
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: GATA_PROM5
Sequence: MNFNSFRKEIKSGNASVKELINEFFLKIDSLDPKINAYTCLTKEIANSQSEQIDKLISNNEQLPPLAGIPIAIKDNICTKGVVTSCSSKMLQDFVSPYESTVSGKLWSSGGIFLGKTNLDEFAMGSSTETSVFGTTSNPWDTKRVPGGSSGGSAASVAAGLCAASIGSDTGGSIRQPASFCGVVGLKPTYGRVSRWGLIAFASSLDQIGPITNTVSDAAEILYSMSGKDPLDSTCLDKPVPNYLSDLDKSIKGLKIGIIEECFNHPGLDQEVKLSVLSAVDRLKSLGAEIHDVKCPRFNDGIATYYVIAPCEASANLARYDGVKYGYRSDGDTNLVEMISKSRAEGFGNEVQRRILIGTYALSAGYSDAYYKKAQRVRTLIRKDFDSAFDKVDVLLTPTCPTTAFLKGDFINDPLSMYLSDLLTVPANLAGLPAISIPCGFDKKGLPIGLQLIGNVLEEHRILNVANIFEKDADVMKRKPSIEI
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: HRT3_YEAST
Sequence: MIVDYEKDPRAKEAIAIWEKGVLKEKDGSMSDAINFYRSALKIHDNVESLYRKKILDEWMLHKKLSGLSMTTDAPDEQNETGKDDLSVEENAELQPCWILEILPDDILLRIIKKVILMSGESWVNLSMTCSTFSKLCFHDSVPFKTFAKYIYSKQIYDKMAMDLNGITDINTFEKEIWRGDDYRMLRERPYIKFEGVYISVVNYVRYGSNAESSLSLLKPVHMITYYRYFRFYENGQCLRLLSTDEPSAVVKHFSKENKPRHSHMCYWSLGFDYDFGHLKITRSDEKYTFIEEFQIKNQGNKRYQRLKWLSSIVVDKEGNASNCSLRNEKSFFFSRVKSFKDPG
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Probably recognizes and binds to phosphorylated target proteins (By similarity).
What are the official names of this protein?
F-box protein HRT3, High level expression reduces Ty3 transposition protein 3.
Protein: SNA3_YEAST
Sequence: MDRDHINDHDHRMSYSINKDDLLLMVLAVFIPPVAVWKRKGMFNRDTLLNLLLFLLLFFPAIIHACYVVYETSSERSYDLSRRHATAPAVDRDLEAHPAEESQAQPPAYDEDDEAGADVPLMDNKQQLSSGRT
What are the official names of this protein?
Protein SNA3.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner.
Protein: ADEC_STAMF
Sequence: MVLPKIFSYDIDERINLIQTITGKKPADIVISNVNLVLTPTGEILDNASIIISGKRIAGAGKYSELHRFIGKNTLVIDGENNYAMPGFIDPHIHIESSLLTPHGFAKLALRHGTTTVVADPHEIGNVLGSRGVEIFMDAARNLPLKILIDIPSCVPATDPKFGLETTANIIGADEVEKLAALEGTIGLGEVMDFVSVLNSNKSVLEKIRVAHRYRLIVNGHAPLLRGAELDAYIDAGIWSDHESTIYEEALEKARKGMYVFIREGSAWKDLKALLPLIKNHTIDHRFLSFASDDINVVDLMEKGHMDRIINIAIEYGVDPVKAIQLATIGPAMRIHLEDHVGVVGPARLADIVLSKNIEYIKPHTVIANGEIIYYKGELKKTFNNYKYPEETLNTVKLAKIPEPQEFIPKINTREGIVEANIIEVTPGSALTKHVIEELAVKNYNVLADPNRDIIYAAVIDRHKATGSMGKGFIKGLGFRAGAIAQTIAHDTHNLIVAGNNPEDMSRAVKRIVEIQGGIVVVDEGKIIGELPLRLAGLMSIEEPETVYEKYKKITNELNNGYGLEFESFFMTLALVALPVIPEIRLTDKGLVDVRKAKLIPLINK
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: RUVC_SULNB
Sequence: MNILGIDPGSRNLGYCILHWDGKKFSLVEAGLLKIKTKELQEQIVELVEGIDIILKAHQIDEVAIEDIFFAYNPQSVLKLAQFRGALSLKILQEIGYFYEYTPLQVKKAVTGNGKATKEQVAFMVKRLLGIKKEIKPLDITDAMAIAITHLQRVKMRKK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: COX3_ASHGO
Sequence: MLYLNRSKFQQFPFHLVTPSPWPIVTSFSLLGLTLTLAFTMHGIIGNIYPLLLSLLVVLLTMTLWFRDIVAETTYLGDHTLAVRKGINLGFTLFVVSEVLIFASLFWAYFHSAMSPDITLGNVWPPVGIEAVQPTELPLLNTIILLASGTTITYSHHGLIEGNRKHALSGLTITFWLIVTFVLCQYIEYSNTSFTITDGIYGSVFFAGTGLHFLHMVMLTIMLGINYWRMRNYHLTSTHHVGYETTTIYLHVLDIIWLALYICFYWWGV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AT11A_HUMAN
Sequence: MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF
What is the function of this protein?
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401).  Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372).  Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells.  In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007).  May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
What are the official names of this protein?
Phospholipid-transporting ATPase IH, ATPase IS, ATPase class VI type 11A, P4-ATPase flippase complex alpha subunit ATP11A.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A.
Protein: FOLD_STRCO
Sequence: MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRELNEDPACTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPNGILTLLRRYGVEIKGAEVVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLKRADIVIAAAGSPHLVRPEDVKPGAAVLDVGVSRNAEGKIMGDVHPGVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERSAG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DIAA_SALG2
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: SECA_CLOBJ
Sequence: MGILNKIFGTYSERELRRVNPIVNKIEALDEKMQSLKDEDFKLKTEEFKSRLEKGEKLDDILPEAFALVREAAHRTIGLKHYREQLIGGVVLHQGRIGEMKTGEGKTLVATLPAYVNALTGKGVHIVTVNDYLAKRDRDLMAPVYEFLGLKVGVILHNLNNEERQEAYGSDITYGTNSEFGFDYLRDNMVVYKEERVQRKLNFSIVDEVDSILIDEARTPLIISGQGEKSTEFYKVADYFTKSLIAEKDFTIDEKANSAMLTDEGVNKAENFFKVDNYADAENMEIQHHVVQALKANYVMKKDKDYMIKDGEILIVDEFTGRAMEGRRYSDGLHQAIEAKEGVRVERESKTLATITYQNYFRMYNKLSGMTGTAQTEENEFREIYGLDVIVIPTHEPIARIDNADVVYKSEKGKFKAIVDEIVERYKKGQPMLVGTVSIEKSEMLSSMLKKKGVPHQVLNAKYHEKEAEIISHAGEYGMVTIATNMAGRGTDIKLTKEAEEAGGLMIIGTERHESRRIDNQLRGRSGRQGDPGESRFFVSLEDDLMRIFGSERIQGIVDKLGLAEDEAIESKMVSSAIESAQKKVEGNNFDIRKTLLQYDDVINKQREIIYKQRSEVLEGEDLKDQIRDMIRDVVYTAVNSHISGVEEEFETELQNLVNYLEDICLPKALVKVKDISNLSDEEIKEKLLEAVENIYSRKEKEIGEEQIREIERVILLRVVDTKWMDHIDDMDHLKQGIGLRAYRQQDPVQAYQFEGSEMFEEMIYNIKVDTVRYLFHVEVEKAPEREKVAKETSTNYDEDSVKKQPIKKENRIGRNDMCPCGSGKKYKNCCGRMA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: MFL3_PHOSM
Sequence: MSLSIPGLEYCRFRQTSRALRRILSFSTTTSPCFADRSTEGMSKRREHPPLPGKQQDIWPPSLSGMEQPVPSFKSFIRKTPPPTGSPGEKPLPPLPTLHRESVDTTPSAAINTSPTRTPSVPFWKAPANWDDSSTPVQEHQAPPVFSPRNYALLLPEASPGGLDSNEPTQWPFDVAATHHPRLNSIDEQVDQVSLSSACHLSAASASRSSSPRPDDDPSTLSSNSNNDRLVINTTKLYSTSSESSASHNMSPVSPSEVMFSPSNVSTKQKVFGIELPGGPGTTIEDWSSRTPSNPRSETPKSGLSMQGKKLQRLNRPISTIDPHPSDPDISAKAQHLDASLDYHSVLAGVYHEEHAHDARPTAARQKNKVPPSTRINPGKQRSGNREMVPRPLSWRKDSNSSFPNSALVDIEEDPKRVPNSRKRYRKMTNWVPFHQPMHMHKGVSQRVEETGSNNGSRYPKRKGKDSPESGGVHGKEADGKSLMPHVRDFATHVKNGIVSTSHAANRSITSSPSQPSTASTPPRAEQHTRLIRLGGGFALVRQSPAVTPPSHSSSRLDISLPLQAPVSRSYGQIPDIEVEPVSRRPSSLYSQQSEAPVAPGISVNKRNLRISPSLSPQTRSNTSSPPTSPLAHEVSFPRTPPPPARSPNRPPYRPQKGAEVVEDERVDSANEDKSHKKSLHVGIMDMARDARHAWKKHHQDAKHEKLKQSIRVLGPTDPGVAAAGVLVHLTPKAFIHHSSLLNTRTMRTLTIPAAVVKRKQACNSCRHRKRKCDAERPVCGLCRRWGIACEYNVPAAERGNPATGTAQPLQAPTRVPVLPGINVDAREAFPDAQTIGLDLDFTSAESGFGYPALQSISQSRNAPNDQDPIASFQLPNHDLLVEMVTLFFDNLYHLFPCFHRKEFMKQLEEGTIQKESTLILFSMCCLAARVHPDAAVKKRQQEWYEQAKFSYQLTQRDPYPALRTIQAALLLIAHASTAGDFSSSWLFLGKVWRQAVALGINRMDTRNAASMGIKPQHWNSGHEQVYGLDKKEGRNAVEKEEYRRTLWLLLVMDRNHAWPTGWPNALPISHFKVDLPIADSLFQEMTPEVQDAPSSNVPFVRNFSCLLGSLSSVTNPAVNVFQYICVAYVLLGQVSEVVHTLQDEVDTLEYLQACEELDSQIVKLRLSLPRKATSILEASPEDRGHVVWLQVMLNSCAMLLYYRCVKDESPKDDATNTFLHAVTAAQNVAQV
What is the function of this protein?
Transcription factor that likely regulates the expression of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a lead compound for the treatment of hyper-cholesterolemia by targeting squalene synthase (SS).
What are the official names of this protein?
Squalestatin S1 biosynthesis transcriptional activator L3.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_POPDE
Sequence: MAETFLFTSESVNEGHPDKLCDQISDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKADVDYEKIVRDTCRNIGFTSADVGLDADNCKVLVNIEQQSPDIAQGVHGHFSKRPEEIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYYNENGAMVPVRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGESGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDKEILQIVKERFDFRPGMISINLDLKRGGNSRFLKTAAYGHFGRDDPDFTWEVVKPLKWDNKVQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIT_ECO81
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNTICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDR3_ASPFU
Sequence: MLAMAASAEETNRQSNAGRRSVISPSEAPPEAEQSDVYQAPPPGLKEWLFILILCSTQLFVQGAFGYILIPLHIVGQTFGQGPSEATRMTWHVGGYSLTVGTFILIAGKLGDLYGSKRILVLGWAWFGVWSVIGGCSAFTHSPVFFDTARALQGIGPALLLPNALAIAGRTYPPGKKKNMIFSAFAVAAPLGCFTAGVVGSVFAQYVWWPWVMWTYSIGCFIIAAVGLWVIPSDYPRCQKAATLQFDYIGSVLGVAGLLLLNISWNQAPIDGWSTPYVYVLLIGGFLVLGLFELQERRAPGIRSWINFAMCLLWIQQCSSRQGPSQGILPALATPYLMAVITSGWLMAIACAAFLGGCILQSTAPVEQSYWMNTFWSFVIMAWGMDISFPASTTILSDAVPVKHQGASASLVNTVINYSIAIGLGIAGTVEAEVSHQGVNQLRGYRAALWSSVGLAALAFGIALVFAVCTFQEQRSSRKSSQEREQRACIEGCILGLTLTPDREWERVELGRLLSHVSQTGGLRSQSV
What is the function of this protein?
Major facilitator superfamily transporter that confers resistance to azoles such as itraconazole.
What are the official names of this protein?
Major facilitator superfamily multidrug transporter mdr3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.