PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_HELHP
Sequence: MQFSFLTLFPTLIESYFTDSILKRALQNGLISVEALNIRDYALDKYQKVDEPPISGGAGQVIRADVLGAALQTLTHSHIIFLSPCGKPFQQYDALRLSHKKHITFVCGRYEGFDERLVEQYANEVMSVGNFIVTGGELPALMLCDSIARHIQGVLGNADSLQGESFEDYLLEAPNFTKIFNQKIKFSATPSEYSKGNHSKISGLKKRLAICKTKYFRPDLYQAYRVFIEQQQLNNKVVK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_NIACI
Sequence: MKVGVLALQGAVAEHIRLIEAVGGEGVVVKRAEQLAELDGLIIPGGESTTIGKLMRRYGFIEAIRDFSNQGKAVFGTCAGLIVIADKIAGQEEAHLGLMDMTVQRNAFGRQRESFETDLPVKGIDRPVRAVFIRAPLIDQVGNGVDVLSEYNGQIVAARQGHLLAASFHPELTDDSSMHAYFLDMIREAR
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: 3L21_DEMVE
Sequence: MKTLLLTLVVVTIVCLDFGYARTCLKTPEVKSEPCPPGQEVCYTKAWCDRMCSFRGKVIELGCAATCPRQEPGKEITCCSTDDCNTHP
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin LNTX-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BPT_ALKEH
Sequence: MGRNDLIRRLPVYATGEHDCPYLDGETACTWFVDPDASLSPGLYSNLIRQGYRRSGRYIYRPGCDACHACQSLRIPVHRFRSRRRHRRCLKANAGATVEPLPSTYREEHYQLYCDYLQARHPGSEMSDPAIGDYLEFLRTDWCETLFYEFRDENDTLLGVAATDLVADGLSAVYTFYRPDLPERSLGTLAILWQINEARRLGLDYVYLGYWIKGCDQMRYKADFRPHEVFNGGRWLTVA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSZ_PSEFS
Sequence: MPAPALSGPQYLREGLKLVLSPGLRLFVLLPLAINLVLFVGLIYFAGHQFSLWVDHLMPTLPSWLSFLNYLLWPLFVVLVVLMVFFTFTMLANIIAAPFNGFLSEKVEVVVRGTDDFPAFSWGELIAMVPRTLAREMRKLGYFLPRAIGLFILSFIPVVNLIAAPLWLLFGVWMMAIQYIDYPADNHKLGWNEMLAWLRQKRWQSMSFGGIVYLVLLVPVVNLLMMPAAVAGATLFWVREQGAEAMAPQQKVTRS
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TFL1_ARATH
Sequence: MENMGTRVIEPLIMGRVVGDVLDFFTPTTKMNVSYNKKQVSNGHELFPSSVSSKPRVEIHGGDLRSFFTLVMIDPDVPGPSDPFLKEHLHWIVTNIPGTTDATFGKEVVSYELPRPSIGIHRFVFVLFRQKQRRVIFPNIPSRDHFNTRKFAVEYDLGLPVAAVFFNAQRETAARKR
What is the function of this protein?
Controls inflorescence meristem identity and is required for maintenance of an indeterminate inflorescence.  Prevents the expression of 'APETALA1' and 'LEAFY'.  Also plays a role in the regulation of the time of flowering in the long-day flowering pathway.  May form complexes with phosphorylated ligands by interfering with kinases and their effectors (By similarity).
What are the official names of this protein?
Protein TERMINAL FLOWER 1.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVB7
Sequence: MAARLCCQLDPARDVLCLRPVGAESRGRPLPGPLGAIPPASPSTVPTDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHRNLPKVLHKRTLGLSVMSTTDLEAYFKDCVFTEWEELGEEMRLKVFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: CH10_RICCN
Sequence: MSFKPLHDRIAIKPIEQEEKTKGGIIIPDTVKEKPMQGEIVAVGNGIRNEKGEIHPLELKVGDKVLYGKWAGTEIEIKGTKLIVMKESDVFGIIN
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AC100_MYCTU
Sequence: MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQLGVNRQSELPSRLAANPSIAGWLRELEAVCTEFG
What is the function of this protein?
Acyl carrier protein that accepts acyl-adenylates (acyl-AMP) from FadD10.
What are the official names of this protein?
Acyl carrier protein Rv0100.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
Protein: SYY_CALS4
Sequence: MSVLEVLKERGYIAQMTHEEEIEKLLEKEKITFYIGFDPTADSLHVGHLIQIMTMAHMQRAGHRPIVLLGGGTALIGDPSGRTDMRKMLTKEEIDRNAEAFKKQMERFIDFSEGKAIMENNAKWLLGLNYIEFLRDIGVHFTVNRMLEAEAFKTRMERGLTFLEFNYMLMQAYDFLELYRRYGCVMQMGGNDQWSNIIAGVELIRKKEGKQAYGMTFVLLTTSEGKKMGKTEKGAIWLDPKKTSPYEFYQYWRNIGDADVEKALALLTFLPMDEVRRLGRLRDKEINEAKKVLAFEVTKLVHGEEEALKAQKAAEALFEGGGEMEHVPSIEVSQDIIGRKIVDVLFEAKVIPSKSEGRRLIQQGGLYINDKRVENVDECIKEEMVKENAILVRKGKKEYHRLLVKE
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1C_ACOCL
Sequence: MKEQKLIHEGLITESLPNGMFWVRLDNEDLVLGYISGRIRRSSIRILPGDRVKIEVSRYDSTRGRIIYRLRNKDSNE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RISB_CLAM3
Sequence: MSGHGAPDIDPTALDGSGLRVTVVAGRWHDEISAGLLAGARRVLDAAGVTTTVIRVPGSFELPVVARAALDAGADAVVALGVIIRGGTPHFEYVSDAATSGLTQASLLAGKPIGFGLLTLDDEQQGIDRAGLPGSKEDKGAEAAEAAVTTALLLKSIRGA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: UGDH_MOUSE
Sequence: MVEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSADDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHSELQTIGFQIETIGKKVSSKRIPYTPGEIPKFSLQDPPNKKPKV
What is the function of this protein?
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:9737970).  Required for the biosynthesis of chondroitin sulfate and heparan sulfate.  Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (PubMed:14505572).  Required for proper brain and neuronal development (By similarity).
What are the official names of this protein?
UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Protein: URK_LACLM
Sequence: MKKTLIIGVTGGSASGKTSVSHAILETFSNERIAMIEHDSYYKDQSHLTFEERTKTNYDHPLAFDTDYLIAQLKELQYGRAVDIPIYDYAKHTRSQETYRQEPVDVLIVEGILVLEDERLRDLMDIKIFVDTDDDVRIIRRIRRDIEERGRTLDSVITQYLEAVKPMYHQFIEPTKRYADVIIPEGVSNTVGVDIITTKIASILND
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_BORA1
Sequence: MSKPAMRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEIPDEKAQKALKGVIMELEDCAFPLLQEVTAHADPKTAFKDADVALLVGARPRGPGMERKDLLTVNAQIFTAQGRALNEVASRNVKVLVVGNPANTNAYIAMKSAPDLPAKNFTAMLRLDHNRALSQLAGKSGKAVAGIEKLIVWGNHSPTMYPDYRFATVDGQPLAKLINDEAWNRDTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGSNGKWVTMGIPSDGSYGIPEGIIYGFPVTTANGEYTMVKDLEVDAFSRERMDFTLKELLEERDGIKDLLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: RUVB2_CAEEL
Sequence: MATLDGINVKDIVKVERTSVHSHITGLGLNDRLEAEYVSGGMVGQVAARQAAGLIVKMIQEGKIAGRALLVTGEPGAGKTAIAIAISKELGEDTPFVSIVASEIYSNEINKTEALTQAFRRALGIQIKEETEVLEGEVISLEVDRSANGMGPKVGKLTMRTTDMETIYDLGSKMVDACLKEKVMPGDVIQVDKASGRVTRLGRSFNRSHDYDAMGPKVKLVQCPDGEIQKRRETVHTVCLHDIDVINSRTQGYVALFSGDTGEIKAEVRDQINKKVLEWREEGKAKFVPGVLFIDEAHMLDIECFSFLNRAIEGELSPLIIMATNRLIEKVRGTDVESAHGIPSDFLDRMLIINAIPYTKEDTAKILSIRCDEEGVKLQPTALDLLVKLQEATSLRYCIHLIAASEVIRIRSKAEIVTTDHIGSAYRLFFDTKRSEKILTEESAGFLQ
What is the function of this protein?
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity).  May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity).  Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity).  Has a role in gonadal development (PubMed:25437307).  Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260).  Specifically, negatively controls the expression of ER homeostasis regulator ckb-2 in a cdc-48. 1/2-dependent manner (PubMed:25652260).
What are the official names of this protein?
RuvB-like 2, Reptin.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL11_PHOV8
Sequence: MAKEVAGLIKLQIKGGAANPSPPVGPALGSKGINIMEFCKQFNARTQDKAGKILPVIITYYADKSFDFVIKTPPVAIQLLELAKIKSGSAEPNRKKVAEITWEQVRTIAQDKMVDLNCFTIESAMTMVAGTARSMGIAVKGEFPGNN
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ASTN1_MOUSE
Sequence: MALAGLCALFACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELPYFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVTSCVIGLVCSSHVSCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPEDPTLYNILMFCGCIEDYKLGVDGRSCQLVTETCPEGGDCGESREVPMNQTLFGEMFFGYNNQSKEVATGQVLKGTFRQNNFARGLDQQLPDGLVVASVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVALLDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLWLEYEDISKGNSPSDESEERERDPKVLTFPEYIASLSDSGTKRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVTRASPIYELVTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSNLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDHSKVETETVLSFVDDIISGAKAPCAMPSQVPDKQLTTISLIIRCLEPDTIYMFTLWGVDNTGRRSRPSDVIVKTPCPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGEFTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRGSLKYLGCRYSEIKPYGLDWSELSRDLRKTCEEQTLSVPYNDYGDSKDI
What is the function of this protein?
Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum.  Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
What are the official names of this protein?
Astrotactin-1, Neuronal migration protein GC14.
What is the protein family that this protein belongs to?
Belongs to the astrotactin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Perikaryon. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell.
Protein: LPXD_HELHP
Sequence: MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGAVFIRPHLLDKVPSHIQPLVVENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIGDNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSIIGNRVNIHAGSIIGCDGFGYAHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVGEHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGHPLMELNEWMKFYVSLRRLIKKDSKKL
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: ALR_CORGL
Sequence: MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVATLAEAMQLRDIGISQEVLCWIWTPEQDFRAAIDRNIDLAVISPAHAKALIETDAEHIRVSIKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLACADEPENPETDRQIIAFRRALALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGLEHGLKPAMTWEAKVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGLDYPQVGRVCMDQFVISLGDNPHGVEAGAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAYV
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: ASM3A_MOUSE
Sequence: MALLGNFLCCLLVAWLCGPGLGVPLAPADRAPAVGQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNLDSMSYDDCLKQHL
What is the function of this protein?
Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860).  Has in vitro activity with p-nitrophenyl-TMP.  Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates.  Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine.  Has in vitro activity with CDP-ethanolamine.  Does not have sphingomyelin phosphodiesterase activity (By similarity).
What are the official names of this protein?
Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a.
What is the protein family that this protein belongs to?
Belongs to the acid sphingomyelinase family.
Protein: TX8D_ANEVI
Sequence: MASTRLFVLLVIGTVLLCQVSGFLDELLAEHELPQDMTKRGCRNAYSSAICGKVITADDCMRKSSSRMGSFARKKCQRLCGIC
What are the official names of this protein?
U-actitoxin-Avd8d, U-AITX-Avd8d, Avtx-4.
What is the protein family that this protein belongs to?
Belongs to the sea anemone 8 toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: DIC_HUMAN
Sequence: MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS
What is the function of this protein?
Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846).  Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes.  Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity).
What are the official names of this protein?
Mitochondrial dicarboxylate carrier, DIC, Solute carrier family 25 member 10.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: PHB2_XENTR
Sequence: MAQNLKDFAGRLPAGPRGMGTAMKLLLGAGAVAYAVKESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRFPWFQYPIIYDIRARPRKISSPTGSKDLQMVNITLRVLSRPLASELPFMYQRLGLDYDERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSIILDDVAITELSFSREYTAAVESKQVAQQEAQRAQFLVEKAKQDQKQKIVQAEGEAAAAKMIGDALSKNPGYLKLRRIRAAQSIAKTIASSQNRVYLNADSLVLNLQDDTFTRGSDSLVAKQTKK
What is the function of this protein?
In the nucleus, serves as transcriptional co-regulator.
What are the official names of this protein?
Prohibitin-2.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane.
Protein: UPPP_STRT1
Sequence: MEIIMQTAQYIIELLKAVFLGIVEGITEWLPISSTGHLILVNEFLNLRQSKDFIDMFNIVMHLGAILAVMVIYFKRLNPFQPGKTAREVQLTWKLWLKVVIACIPSAFFGLLLDDWMEAHLSNFFVVAIMLVVYGIAFIWIEDRNRRVDPKVTDLARMSYKTAFYIGLFQVLSIIPGTSRSGATILGGIIVGTSRSVAADFTFFLGIPTMFGYSGLKAVKYFIDGNTLTGGQAAILLVASVTAFLVSLFVIRFLMNYIKKHDFTVFGKYRIVLGIIVLFYGAVKLIFG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NPCC_RHOOP
Sequence: MHTTDTETFEEQFAIEQRLVDSVVASFDSTTDPRLKELMQSLTRHLHAFIREVRLSEDEWSNAIAFLTAVGNITDDRRQEFILLSDVLGVSMQTIAVSNPAYEDATESTVFGPFFVEDAPEVTLGGDIAGGATGQPCWIEGTVTDTAGNPVPEARIEVWQNDEDGFYDVQYSDGRVSGRAHLFSDAHGRYRFWGMTPVPYPIPSDGPVGKMLAATNRSPMRVAHLHFMVTADGLRTLVTHIFVAGDPQLERGDSVFGVKDSLIKDFVEQPPGTPTPDGRHIGDRNWARCEFDIVLAPEQI
What is the function of this protein?
Involved in the degradation of para-nitrophenol (4-NP).  Catalyzes the conversion of hydroxyquinol to malelylacetate.
What are the official names of this protein?
Hydroxyquinol 1,2-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the intradiol ring-cleavage dioxygenase family.
Protein: ARGR1_YEAST
Sequence: MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSPEQDQEGDFDEEDDDDKFSVSTSTPTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANILLLILANSGLVYTFTTPKLEPVVREDEGKSLIRACINASDTPDATDTSPAQEQSPAN
What is the function of this protein?
With ARG81, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.
What are the official names of this protein?
Arginine metabolism regulation protein I, Arginine-requiring protein 80.
What are the subcellular locations of this protein?
Nucleus.