PharMolix/UniProtQA huggingface dataset:
Protein: SYC_CLOB6
Sequence: MKVYNTLTNKKEEFLPLVPGEVKMYVCGPTVYNFFHIGNARTFVVFDTIRRYLEYRGYKVKFIQNFTDIDDKMIKKANEEGTTVKELGDRFIKEYYKDADDLNIERATKNPRATEFMKEIIKFVSDLIEKGYAYEIDGDVYFSTKKFNSYGKLSGQNLEELQLGARINVDERKKDPMDFAIWKSQKPEEPAWESPWGMGRPGWHIECSCMAYNLLGETIDIHAGGSDLSFPHHENEIAQSEARTGKQFAKYWLHSAFVNVNNQKMSKSLNNFFTAREILEKYDADVLRMFMLSGHYRTQINFSMELLDSTKAALDRLYNSINNLENLLDEVKNEGLRDEELKYRDELQKYKEKYIEKMDDDFNTADAISVIFDLIRDVNTNITIESSKELVKYALDLIRELGSPLGILQKSTKASLEEEIERLIQERQKARKEKDWALADKIRDDLKERGIVLEDTPQGVRWKQI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSB2_LISMO
Sequence: MMNRVVLVGRLTKDPDLRYTPAGVAVATFTLAVNRTFTNQNGEREADFINCVVWRKPAENVANFLKKGSMAGVDGRVQTRNYEDNDGKRVFVTEVVAESVQFLEPKNNNVEGATSNNYQNKANYSNNNQTSSYRADTSQKSDSFASEGKPIDINEDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein 2, SSB 2.
Protein: RSMJ_ALTMD
Sequence: MLNSVPLVIAQHSTQDDTSLLNSIGNKWGFPVVSHSEKPAEGFYLQIQNGVLGLADASEKKVLPVEVDFASPASLYRKQHGGGRKEPIVKAIGLKGNEGWHVVDATPGLGRDAFVLVSVGCKVTMIERSPIVAALLEDGIRRLALSFPELAAKMSLQHGNSAEVMQYFTGENVNAIYLDPMFPHKKKSALVKKEMRLFQQLLGHDPDADALLPPALKLATHRVVVKRPNSADVLAGEKPSMAIESKKHRFDVYLCQKP
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_ALIFM
Sequence: MRLNTLSPAAGSKPSKKRVGRGIGSGLGKTGGRGHKGQKSRSGGKVRAGFEGGQMPLKQRLPKFGFTSRKSLVTAEVRLSELAKVEGNVIDLNSLKAANVITKNIEFAKVVLSGEIATAVTVKGLRVTKGAKAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AP3B_SCHPO
Sequence: MSNLSFFQTLSGLAENAKQIAKSSSLSFEENELSHSDLLRLLNSNSDAGKLEAINFILAQMMHGENMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSLDPSYKSQLEEHIKTLLSDNSPIVVPAALFTFEVVCPEKLEIIHPYYHRICTLFPQMNDWDKVVALKTLVRYARLTLPEPSTPSTHSDLKELLESIKSCFFSLLPSTIIAGARAFYYLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPSCLNTLLLLLKSHNSLIVTEAASSLRLLIHNDPKEIYLQYLAATYETLEVPRAKSVTLWLISEHILIIPRLVPDVLRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLIHFDMSYDLRDRARFYKELASTPSSEFTRRIVLESKGNSQKEIIASRDYCIGTASLCLNEDVMGYEPIPNWADVSDLPPDSVREGIKDVLPINPHTGNIYSNNSPGVKALSSDNFKRDFGDTNAINRPKFVGQQTLEEFYASETSESSEGEYETSTSESEDEETDDTSQEEDNEKNSTPDEDTENNNTSSISTKSIMDRPLTEPEPNYWQS
What is the function of this protein?
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.  Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).
What are the official names of this protein?
AP-3 complex subunit beta, Adaptor-related protein complex 3 subunit beta, Beta-3-adaptin, Clathrin assembly protein complex 3 beta large chain, Clathrin assembly protein large beta chain.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: Y416_STRSY
Sequence: MDTKSLLVTGYRHTDLGIFSEKDPRLHIIKSAIRRNFIRFLEEGVSWFILTGQLGFEYWSLEVLEDLRAEGYQLSIATIFPFENHGEQWNEANQAKLARFKQVDFVKYAYPRYENPGQFRDYNQFLLDNTTGCYLFYDSENETNLKYLYHMVLKKEGYNRKTLTFEELNEEAENFSNSE
What are the official names of this protein?
UPF0398 protein SSU05_0416.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: CBP3_ORYSJ
Sequence: MATARVSLILLVVVLAASACAEGLRLPRDAKFPAAQAERLIRSLNLLPKEAGPTGAGDVPSVAPGELLERRVTLPGLPQGVGDLGHHAGYYRLPNTHDARMFYFLFESRGKKEDPVVIWLTGGPGCSSELAVFYENGPFTISNNMSLAWNKFGWDTISNIIFVDQPTGTGFSYSSDDRDTRHDETGVSNDLYSFLQVFFKKHPEFAKNDFFITGESYAGHYIPAFASRVHQGNKANEGIHINLKGFAIGNGLTDPAIQYKAYTDYALDMNLIKKSDYDRINKFIPPCEFAIKLCGTNGKASCMAAYMVCNSIFSSIMKLVGTKNYYDVRKECEGKLCYDFSNLEKFFGDKAVKEAIGVGDLEFVSCSTTVYQAMLTDWMRNLEVGIPALLEDGINVLIYAGEYDLICNWLGNSRWVHSMEWSGQKDFVSSHESPFVVDGAEAGVLKSHGPLSFLKVHNAGHMVPMDQPKASLEMLRRFTQGKLKEEWLAELPEQPMYAAM
What are the official names of this protein?
Serine carboxypeptidase 3, Serine carboxypeptidase III.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
Protein: SULA_SHIFL
Sequence: MYTSGYAHRSSSFSSAASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLTDDLTEEEHAELVDAANEGNAMGFIMRPVSASSHTTRQLSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: PTH_PSEPW
Sequence: MTAIQLIVGLGNPGPEYEQTRHNAGALFVERIASAQRVSLTADRKYFGLTAKFSHQGNDVRLLIPTTYMNRSGQSVAALANFFRIKPEAILVAHDELDLPPGVAKLKRGGGHGGHNGLRDIIAQLGNQNDFHRLRLGIGHPGDAKLVSNFVLGRAPRAEQEKLDASIDFALGVLPDVLAGDFAKAMRELHSQKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_PROMS
Sequence: MKGLKNQIMKKTSLFICTLLFISSIVFYPKISFAYPFWAQQNYESPREATGKIVCANCHLAQMPTIAEVPQSVGADSVFKAVVKIPYKNDLKEIGADGSEVPLQVGAVVMLPDGFKLAPQERWTEEIKEETEGVYFTNYSEEQDNIIIVGPLPGDTNKEIVFPVLSPDPSTNKEYHYGKYSLHIGGNRGRGQVYPTGDKSNNVVFTSSTAGTINSIETIEDGSYQVNIENDNGEITTEAVPVGPQLIVKAQDKINVGDPLTNDPNVGGFGQLDAEVVLQSPYRVIGLIAFFIGVGLTQILLVLKKKQVEKVQAAEGI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: AHBM1_STRPT
Sequence: MTHISNNRPRIAVIGGGIAGLTVAASLLRAGIECTVYEQATVFADAGAGIQIAPNSARILHRLGLAGALERRATRAHAIETRRWQDGAPLARTELGEPCVERYGAPYYLIQRADLHRSLLELLPPGVVRHSAACTAVEERPDGVTLRFADGTSEEAGVVVGADGIHSALRNHLVGDRPRFSGHTVHRGLVAADRLPSLFEVPKVLFWLGPNGHVTSYPIAQHGLVHFSAVITSPEWDPEVWSAPSRPGEAAAAFAGWNAEVAELIGAAEQAHHWALFDRDCVGGWSTGRMTLAGDAAHPMVPYLSQGANQAIEDAWVLADLLGAADLDPGPALRRYEELRLPRVREVHRRSRERGHEFHLPDGPQQRLRDRSMPTAERLDDYAWIYGFEAAPVGSR
What is the function of this protein?
Part of a gene cluster involved in the biosynthesis of thioplatensimycin (thioPTM) and platensimycin (PTM), potent and selective inhibitors of bacterial and mammalian fatty acid synthases (PubMed:21825154, PubMed:29915173).  Catalyzes the hydroxylation of 3-amino-4-hydroxybenzoate (3,4-AHBA) to 3-amino-2,4-dihydroxybenzoate (3,2,4-ADHBA) (Probable).
What are the official names of this protein?
3-amino-4-hydroxybenzoate 2-monooxygenase PtmB3.
What is the protein family that this protein belongs to?
Belongs to the 6-hydroxynicotinate 3-monooxygenase family.
Protein: RDGC_BORBR
Sequence: MWFKNLKIYRLSAPWALNGDQLEECLARFAYQGGNNLEMQSLGWISPRENGLLAHTLNGQILLTLRAEKKLLPTTVVNQVAKARAQEIEEQQGYKPGRKQMKEIKERVTDELLPKAFSIYRDTRVWIDTVNHWLVIDAAASAKADEVIGLLVKTIDPLPLDNLYVEQSPAAAMTGWLAADEAPANFSIDQDTELRASGESRAAIRYVKHSIDVDDVRRHIQSGKQCTRLAMTWADRVSFVLTESLDVKRVAPLDVLKENPDAATQNDDEKFDSDMTLMTGEVAKLLAELVDSLGGEKRV
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: VE2_HPV22
Sequence: MEKLSERFSALQEKLMDLYESGVEDLETQIQHWKLLRQEQVLFYYARRHGILRLGYQPVPTLATSESKAKDAIAMGLLLESLQKSQYAEEPWTLVETSLETVKSPPADCFKKGPKSVEVYFDGDPENVMSYTVWSYIYYQTDDESWEKVEGHVDYTGAYYIEGTFKTYYIKFETDAKRYGTTGHWEVHVNKDTVFTPVTSSTPPVGVASQNSAPEPASTSDSPQRSSQVTHRYGRKASSPTITTIRRQKRRERQRQETPTRRRKTRSRSRSTEQRGGRATRRSLSRESAESPRRGGRGGGGPLTRSRSRSRSRTRESVDGGGVAPDEVGATLRSIGRQHSGRLAQLLDAAKDPPVILLRGAANTLKCYRYRFRKKHAGSFQFISTTWSWVGGHTTDRIGRSRILISFHTDREREKCLQQMKLPLGVEWSYGQFDDL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ALDOC_MOUSE
Sequence: MPHSYPALSAEQKKELSDIALRIVTPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGILVGIKVDKGVVPLAGTDGETTTQGLDGLLERCAQYKKDGADFAKWRCVLKISDRTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASLNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEMNGLAAQGRYEGSGDGGAAAQSLYIANHAY
What are the official names of this protein?
Fructose-bisphosphate aldolase C, Aldolase 3, Brain-type aldolase, Scrapie-responsive protein 2, Zebrin II.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: YCFP_SALDC
Sequence: MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLVSYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVVFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRHDEALDSQRSAQALHPYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YcfP.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: NPD_MYCPA
Sequence: MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVAPNAGHRAIAAWQDHAEVSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYTGELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPWRRAVEATESADVMVVVGTSAIVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMND1_MOUSE
Sequence: MPSRLLHTLASLHSISAKAHQCQRLTWLTLRPLRKSESTTCHNGLTIQQHLHSFFPSITADSLNKPEILEMSRITSDTSRLFPLNAVHWLDGKEHWPSMHPFGTHRSMTHKPNLLCSKWFIKAVKRHHSSVSNEALVPKQDLPQIKRPLKASRTRQPSRTNLPDLSVNEDLMQCTAFATADEYHLGSLSQELVSCGYVEVTSLPRDAANILVMGVESSAKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQVLERHETQPYEVALVHWENEELNYIKTEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF
What is the function of this protein?
Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
What are the official names of this protein?
Required for meiotic nuclear division protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RMD1/sif2 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=May be localized in mitochondrial RNA granules.
Protein: RHOU_MOUSE
Sequence: MAPQQGRPALPARCEPPAAPPVPPRRERGGRGARGPGVSGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPTSFQNVGEKWVPEIRRHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEVKAVSYIECSALTQKNLKEVFDAAIVAGIQHSDSQLQPKKSKSRTPDKVRDLSKSWWRKYCCLA
What is the function of this protein?
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.  Stimulates quiescent cells to reenter the cell cycle.  Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.  Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the control of cell shape (By similarity).
What are the official names of this protein?
Rho-related GTP-binding protein RhoU, Rho GTPase-like protein ARHU, Wnt-1 responsive Cdc42 homolog 1, WRCH-1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC- transformed cells.
Protein: THIG_PROM2
Sequence: MKNYSSLLIGGKKFSSRLMVGTGKYKSTQDMIESLSNSETEIITVAVRRIKNDETGENLLEKINWKKYWMLPNTAGCVNSDEAVRIAILGRELAKLSGQEENNFVKLEVIPDKKYLLPDPMETLKAAEILIKKGFSVLPYINADPILAKRLEEIGCATVMPLGSPIGSGQGLLNLSNIGIIIESAKVPVIIDAGIGVPSEASQAMELGADGVLINSAIAQAENPPLMAQAINYGVKAGRQAFLAGRIKKQDFATASSPEKNISI
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH1_ASPFU
Sequence: MTEPLLSSAAPEMKMEETSSSSNLRQPKKRFVGRRTADAHAQKDASISSKDVESTSVQRVAPRRNPRTLNQVPPEILDDPEIQAAIELLPKNYSFEIPKTIHRIRTSGAKRVALQFPEGLLIFATTISDILTQFCPGTETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTQIKTLYIFVDISIDTSHLIATLERNFQPGKTIATVGTIQFNATLHGLKPVLERAGFKVVIPQIAPLSKGEILGCTSPQLSPTEIDILLYLGDGRFHLESAMIHNPTIPAYRYDPYSRTLSRETYSHDEMHALRRDAINTAKSAKKWGIILGSLGRQGNPNTMAMIENHLNERGIPFVNLLLSEIFPGKLASMSDVECWVQIACPRLSIDWGYAFPRPLLTPYEALIALGVREHWDSANSGVYPMDFYAKEGLGRTKPQQALQGAA
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_ACHLI
Sequence: MFITFEGGEGSGKTTLIEKLKHTLLEKKYDVLTTREPGGSKVAEKIRSVLLDNKNTEITAHTEALLFAASRAQHLDEVIIPNLDKVILCDRYIDSSYAYQAFGRNLGMEFVQSINSYALKYLPDLTFYIDLDPKTGIDRVKKNRLHKTDRLDMEVQTFHQKVREGYIRISEMFKERIVVIDGNQSIDAIYQIIMDNILKRL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ZN569_HUMAN
Sequence: MTESQGTVTFKDVAIDFTQEEWKRLDPAQRKLYRNVMLENYNNLITVGYPFTKPDVIFKLEQEEEPWVMEEEVLRRHWQGEIWGVDEHQKNQDRLLRQVEVKFQKTLTEEKGNECQKKFANVFPLNSDFFPSRHNLYEYDLFGKCLEHNFDCHNNVKCLMRKEHCEYNEPVKSYGNSSSHFVITPFKCNHCGKGFNQTLDLIRHLRIHTGEKPYECSNCRKAFSHKEKLIKHYKIHSREQSYKCNECGKAFIKMSNLIRHQRIHTGEKPYACKECEKSFSQKSNLIDHEKIHTGEKPYECNECGKAFSQKQSLIAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKAFSQSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCIECGKAFSQKSHLVRHQRIHTH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 569.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RK31_GRATL
Sequence: MTQKSIHPKWFNDTKVYCDGKHVMTVGSTQAELHVDIWSGNHPFFTGSQRIIDTEGRVEKFMRKYNLQSNNDKQSKLEV
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PAK2_MOUSE
Sequence: MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRNKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNTKGSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSNR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:11278362).  Acts as downstream effector of the small GTPases CDC42 and RAC1 (By similarity).  Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (By similarity).  Full-length PAK2 stimulates cell survival and cell growth (By similarity).  Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (By similarity).  Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (By similarity).  Phosphorylates many other substrates including histone H4 to promote assembly of H3. 3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:11278362).  Phosphorylates CASP7, thereby preventing its activity (By similarity).  Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (By similarity).  On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (By similarity).  Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 2, Gamma-PAK, p21-activated kinase 2, PAK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2- ARHGEF7-GIT1 complex to the inner surface of the cell membrane. SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region.
Protein: TX109_LYCSI
Sequence: MMKVLVVVALLVTLISYSSSEGIDDLEADELLSLMANEQTRKECIPKHHECTSNKHGCCRGNFFKYKCRCTTVVTQDGEQTERCFCGTPPHHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1a, Toxin-like structure LSTX-A10, Toxin-like structure LSTX-A9.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 04 (U1-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MSHA_STANL
Sequence: MRTAPRSQLNRAIAPCRKRGPRRVAMVSMHTSPLEQPGTGDAGGMNVYVLQTARRLADRGVAVEIFTRATSSEQPPALSPSEGITVHYVPAGPFEGLSKGDLPSQLCAFTNGVLRAEAAQPPGYFDVIHSHYWLSGQAAWLAAERWGVPHIHSAHTLAKVKNLHLAAEDTPEPFTRVVGEEQVVAESDALVTNTSSEAEVLVDLYRADPDKVTVTPPGVDPEVFTPGDKLAARRRLGLPDDALVLGFAGRIQPLKAPDVLVRAVARLRALNPELAPRLRLVVVGGPSGNGADNPRWLHDLAAELGIADAVTFLKPRAGHELAEVFRACDVVGVPSYNETFGLVALEAQACGTPVVAAAVGGLTTAVADGHSGLLIRGHDETDWANALDKLVTDAPRRARLAAGALDHAARFTWSHTADDLLGAYGDAIQRRAVSPRRSPASKR
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: RS8E_AERPE
Sequence: MGIYQWRDKKKPSGGKRRYYYKVKRKYAAGRPPTYTTLSAAEEEERKPVRARGGSYKIKAKKVAFAVVSNPKTGEARKARILRIVETPAHREYARRGIIVKGAVIDTTLGRAVVTSRPGQEGVVNAVLLEEQGQKQ
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.