PharMolix/UniProtQA huggingface dataset:
Protein: LGT_ECOLU
Sequence: MTSSYLHFPEFDPVIFSIGPVALHWYGLMYLVGFIFAMWLATRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPQFMADPLYLFRVWDGGMSFHGGLIGVIVVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFPFAMLFPGSRTEDILLLQTNPQWQSIFDTYGVLPRHPSQLYELLLEGVVLFIILNLYIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIVAGVIMMVWAYRRSPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SIRE_LEPMC
Sequence: MFFRYTVTLVANETDHHATVVQALLRRHIGDITPGTTQEIENALETVCGQSKEWSSTSLAAIIIAVVARSTSRLLVGPSLCRNNDYINLCIEYATEMESSAAKIRALVPFLRPLIAPYYCRRLAELRKLAHAHIAPLLAGPDSAPKEKNASSQYTAVQWLAQKLRGVPEETEERQVARIMFLNVISIFTVMMASLNVLYDILARPDVKRALLEEIAEVSGGKGDLGLGDVEFERLRRLDSCIRESQRLNPTNWIILEGQAQKDLTFSTGLCVEKGSYLSICGGAILKSNGPPLSTSSNPPPIDEFHAFRYVTPDSGISTDVSTANGNSNANSNLATAISPTNLTFGYGRMSCPGRYFAVHSIKAIVVGLLLRYDVEFEKKDGEERGRPRNVQAGNVIIPDPSVMVRVRARG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Cytochrome P450 monooxygenase sirE, Sirodesmin biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FTSB_ALIF1
Sequence: MRTFAIFLLIALGWLQYTLWFGKNGMSDYAQVSNDVALQEEVNQGLRNRNEQMFAEIDDLKKGSEAIEERARHELGMIKKGETFYRIIDENSEG
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: GSIA_SHIF8
Sequence: MPHSDELDAGNVLAVENLNIAFMQDQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMLLRRRSRDVIELSEQSAAQMRHVRGADMAMIFQEPMTSLNPVFTVGEQIAESIRLHQNASREEAMVEAKRMLDQVRIPEAQTILSRYSHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVAEIADRVLVIYQGEAVETGTVEQIFHAPQHPYTRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQEPPIEQKTVVDGEPVLRVRNLVTRFPLRSGLLNRVTREVHAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNGQRIDTLSPGKLQALRRDIQFIFQDPYASLDPRQTIGDSIIEPLRVHGLLPGKDAAARVAWLLERVGLLPEHAWRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEIGSRCAVFENPQHPYTRKLLAAVPVAEPSRQRPQRVLLSDDLPSNIHLRGEEVAAVSLQCVGPGHYVAQPQSEYAFMRR
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Glutathione import ATP-binding protein GsiA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BIOF_BACCN
Sequence: MEQAWNLHFYASLNRLKEKSQYREVVVTNQAEEPWLIRNGARMLNLASNNYLGLAGDSRLKEAAIEAIRTYGVGATASRLVVGNYSLYEEVEKSICDWKHTEKAMIVNSGYTANVGAISSLMGRHDVIFSDKLNHASIVDGVKLSGAKQKRYRHNDLHHLEQLLQTTPSEKRKLIVTDTVFSMEGDVAHLKELIALKEKYGALLMIDEAHASGIYGERGAGIAHVEPELSKKIDIHMGTFSKALGCYGAYLAGNEVCIDYMRNKMRSFIFTTALPPGVLATIQCAIAIVKEDEARRKRLLENGAYFRNVLKEAGYNIGNSSTHIVPVIVTSNEAAIRFSRKVQEAGIVAIAIRPPTVPHNSSRIRFTVTSEHTKSDLEWAIRQIVNIGKEEGFVE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: GLYA_KORVE
Sequence: MSNRMSQSLNEEDPQIAEAIANEERRQHEGLELIASENFVSEAVLQAAGSVFTNKYAEGYPGKRYYGGCEYADVVENLARDRAKELFGAEHANVQPHSGSSANMEAYGAILQPGDTILGLNLAHGGHLTHGHPLNFSGKTYKIVPYGVTKETETIDYDELEKLALEHHPKVIVGGGSAYPRIFDFKRMREIADKAGALFMVDMAHFAGLVAGGAHPSPVPHAHVVTTTTHKTLRGPRAGMILSKQEFAAAIDKVTFPGMQGGPLVHIIAAKAVCFKEAMEPSFKDYANQVVANAKVLAQSLADQGFRIISGGTDTHLMLIDVFAAGMLGSEAEKALGEAGITVNKNAIPFDTNPPMKPSGVRIGTPALTTRGMKEPEMRQVGIWIAESLRHRTDPDFLGRVRRQVHELCDAYPLYPERRATRLATV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P_STRPQ
Sequence: MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHTNGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.  Also binds human plasminogen.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_PHOLL
Sequence: MSINKEQILDAVATMSVMDVVELITAMEDKFGVSAAAAVAVAAGGAAEAVEEQTEFDVVLSAIGGNKVAVIKAVRGATGLGLKEAKDLVESAPNATLKEGISKDDAEALKKSLEEAGASVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: LMBD1_ASPFC
Sequence: MPLPWISVIWFAYLIVIFVLIVVASVFIHVYQTPRDRSSFVTFICVFSIAALLATVMLLPVDVALVSSTISSALGQREEWATQEEVDKITYSLTIIYYSLYFLDALLCFVGIPFAYFWHEEYDEVAFEAGDQTACKRFWAATKYTLTFIAVVIALVLVGFFAPMMESQPGHDLGYWRGYLIENQGEHAFTFLLGFVTIIGSCLYAFYTPSGLAMLPALFLRKSSSFATQTLGGSTAMELNFNRERQRQLEGRCGGNSALLSAKDRRELDTLVREERTLIRRQRLIEGRQEEDQSWPVTVYSKLKTILRPFRLLGGFCLFLVGLSTWISLLMTVVDKLINSPCKHHCGYVLSRTNFNPISWIFIQSSRAFPTDYIIFALIVFFFFWGSVVGVVAVGIRFLWIRIFQIRKGHTSPQAMLLATAVLTLITLGLNYSIVMMLVPGYATFGPQTFCDLAPTSSEEQSDCSNHRHLVKPCSEKADSTAADKTCTPSVASTILNRVALNFPLFGALLLWAHFLFLAGGGRRRGRGRESVSKHQKKRQSYMRGCPIASREPATSNYERLFKEGFFIFKRR
What is the function of this protein?
Probable lysosomal cobalamin transporter.  Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
What are the official names of this protein?
Probable lysosomal cobalamin transporter.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: SFRP1_HUMAN
Sequence: MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types.  SFRP1 decreases intracellular beta-catenin levels (By similarity).  Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response.  In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity).  In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity).  Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
What are the official names of this protein?
Secreted frizzled-related protein 1, FRP-1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Protein: SRR_SCHPO
Sequence: MSDNLVLPTYDDVASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQLNEAQRKAGVLTFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIMYDRYKDDREKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDALFVCLGGGGLLSGSALAARHFAPNCEVYGVEPEAGNDGQQSFRKGSIVHIDTPKTIADGAQTQHLGNYTFSIIKEKVDDILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAARAMKEKLKNKRIGIIISGGNVDIERYAHFLSQ
What is the function of this protein?
Catalyzes the synthesis of D-serine from L-serine.  Has dehydratase activity towards both L-serine and D-serine.
What are the official names of this protein?
Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: NARH_SHIFL
Sequence: MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGVEYAWFNNVETKPGQGFPTDWENQEKYKGGWIRKINGKLQPRMGNRAMLLGKIFANPHLPGIDDYYEPFDFDYQNLHTAPEGSKSQPIARPRSLITGERMAKIEKGPNWEDDLGGEFDKLAKDKNFDNIQKAMYSQFENTFMMYLPRLCEHCLNPACVATCPSGAIYKREEDGIVLIDQDKCRGWRMCITGCPYKKIYFNWKSGKSEKCIFCYPRIEAGQPTVCSETCVGRIRYLGVLLYDADAIERAASTENEKDLYQRQLDVFLDPNDPKVIEQAIKDGIPLSVIEAAQQSPVYKMAMEWKLALPLHPEYRTLPMVWYVPPLSPIQSAADAGELGSNGILPDVESLRIPVQYLANLLTAGDTKPILRALKRMLAMRHYKRAETVDGKVDTRALEEVGLTEAQAQEMYRYLAIANYEDRFVVPSSHRELAREAFPEKNGCGFTFGDGCHGSDTKFNLFNSRRIDAIDVTSKTEPHP
What is the function of this protein?
The nitrate reductase enzyme complex allows S. flexneri to use nitrate as an electron acceptor during anaerobic growth.  The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers.  Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit.
What are the official names of this protein?
Respiratory nitrate reductase 1 beta chain.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRC_CHESB
Sequence: MKTLTIRQPDDWHLHLRDGSVLQAVAEHSAAHFARAIIMPNLVPPVVTTRDAAAYRERILAALSEGSAFTPLMTLYLTESSCADDIEAGFRSGLIKAVKLYPAGATTNSQSGVRNIEAVYPVLERMAKIGLPLCVHGEVTDPAVDIFDREAVFIERVLQPLRRRLPELRIVMEHVTTKDGVDFALSQDENVGATITTHHLIINRNAILAGGIRPHYYCLPVAKRESHRLALRAAAISGEGRFFLGTDSAPHLDPLKECACGCAGVFNAPNTMACLAHVFEEEGALDRLEAFTSLNGPAFYRLPPNEKRITLRRYDEPLEMERKVSVGDEAITVFDPMFPIHWKVED
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: OPSD_ZEUFA
Sequence: MNGTEGPDFYVPMVNTTGIVRSPYDYPQYYLVNPAAFSMLAAYMFFLILVGFPVNFLTLYVTMEHKKLRTPLNYILLNLAVANLFMVIGGFTTTMYTSMHGYFVLGRTGCNLEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFGENHAVMGVSFTWLMACACSVPPLFGWSRYIPEGMQCSCGIDYYTRAPGYNNESFVIYMFVCHFSIPLTIIFFCYGRLLCAVKDAAAAQQESETTQRAEREVSRMVVIMVIGFLICWLPYASVAWFIFTHQGSEFGPVFMTIPAFFAKSSAIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTTASKTEASSVSSSHVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (PubMed:18422881).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: SECB_PSEPF
Sequence: MTDQQNTAASEEETAPQFSLQRIYVRDLSFEAPKSPAIFRQQWDPAVALDLNTRQKALEGDFYEVVLTLSVTVKNGEEVAFIAEVQQAGIFLIKNLDAASMSHTLGAFCPNILFPYARETLDSLVTRGSFPALMLAPVNFDALYAQELQRMQESGETPTVQ
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSHC_BACC7
Sequence: MEIKEISVPQQGVVADYMNGKKEIQSCFDYMLTEDAFKQRVQDLREREFFRQDLVAHLLEYNTKLQAGEATIQNVKALEDEDTYVVIAGQQAGLLTGPLYTIHKIISVLQLAKEKEESLGVKVVPVFWIAGEDHDMDEINHTFVTKNKKIKKTIFHDRNPKKASASESELSLEDCRKWIEEIFKTYPETNFTKDVLRFIDDSLRKSNTYVDFFGHLIMKMFMNSGLILVDSHHPELRKLEVPFFKQIVSKYKEVQEGLHNQQEVIKELGYKPIIETKSNAVHIFMEIDNERVLLEDNQRKFVGKDGTYSFSYEELIEEMERSPERFSNNVVTRPLMQEYVFPTLAFIGGPGELAYWSELQQVFHAIGFRMPPVVPRITITYIERDIATDLHDLQLQESDPFLNNVDKLRENWLSNQIEEPIDERFEEAKKEIIDIHKSLQQFVKKIDPGLSSFAGKNEFKINEQIELLERMLKRNVEKKHEVELNKFRRIQFAIRPLGAPQERVWNVCYYLNQFGLDFVDRVMEKPFSWDGKHHVIKL
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: IHFA_PSEF5
Sequence: MGALTKAEMAERLYEELGLNKREAKELVELFFEEIRHALEDNEQVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFRPGQKLKARVEAYAGTKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: HIS4_PROM0
Sequence: MNLIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKFWESEGAKCIHIVDLDAAKTGSPTNDKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKYPGRIIVGIDAKNGKVSTRGWLEQSNIFATDLVKEFSSFKIASFIVTDINTDGTLEGTNEEFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTIKEANNVLSSERLNDFDLNRNYYA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SN309_CANGA
Sequence: METYLPFVDDAAVDQAFEAWVDELVEEECGAMPSEGYHPEVPRVMAAKGRDAESGGIDLARYNDAGDVRLLKIVDSYLRHAEITLRELISKTIVNQWVISNDCQQSASGVMQAGIDKLQGQLDALEKYRRDVQVRYRRTHPDTVDASCMRLRDMYI
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SNT309.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIF3A_ARATH
Sequence: MAEVNGDFPVPSFADGTGSVSAGLDLLVERSIHEARSTEPDASTQLTIIFGGSCRVFNGVPAQKVQEIIRIAFAGKQTKNVTGINPALNRALSFSTVADLPIARRRSLQRFLEKRRDRSTKPDGSMILPSQLTIIFGGSFSVFDGIPAEKVQEILHIAAAAKATETINLTSINPALKRAISFSNASTVACVSTADVPIARRRSLQRFFEKRRHRFVHTKPYSATTSEADKNETSPIVT
What is the function of this protein?
Repressor of jasmonate (JA) responses.  Targets MYC2, MYC3 and MYC4 that are JA-dependent transcription activators.
What are the official names of this protein?
Protein TIFY 3A, Jasmonate ZIM domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MATK_KOKDR
Sequence: MEQFQVYLELNRSRRHDFLYPLIFRESIYALAHGHGLNKSMIFFENQGYGNKFSSLIVKRLILRMDQQKRLISSANDSNQNPVFGHNNNLYSQMVAAGFAVIVEIPFSLRLISYSQGAEVAKSHNLQSIHSIFPFLEDKLSHLNYVLEALIPHPIHLEILVQALRYWVKDASSLHLLRFSLYEYCNLKSFITPKKSISIFNPRLFLFLYNSHACEYEFIFLFLRNQSSHLRSTSSGVFLERIFFYGKIKYLGEVFYNDFQNNLWLFKDPFIHFIRYQGKSILASKDTSLLINKWKYYFVDLWQYYFYLWSQSGRVRINQLSKYSLDFLGYLSSVRLNPSVVRSQMLENSFLIDNAMKTLDTRIPIISLIGSLSKAKFCNTLGHPISKPTWADSPDSDIIDRFVRICRNLSHYHSGSSKKKSLYRIKYILRFSCVKTLARKHKSTVRAFLKKLGSEFLEEFFTETEEEHAFSLIFPRGFFALRKFDRGRIWYLDIICIDALVNHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NQOR_AZOSB
Sequence: MAKVLVLYYSSYGHIEKMAEAVAAGARDAGAEVTIKRVPELVPEEVARKSGMKLDQPAPVATVGELPDYDAIIFGTPTRFGNMASQMRNFLDQTGGLWMSGKLVGKVGSVFASTATQHGGQETTITSFHTTLLHHGMVIVGLPYTEARQMNMDEITGGSPYGATTLAKGDGTRQPSENELAMARFQGGHVAKIAAKLAG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: FSHR_SHEEP
Sequence: MALFLVALLAFLSLGSGCHHRLCHCSNGVFLCQDSKVTEMPSDLPRDAVELRFVLTKLRVIPEGAFSGFGDLEKIEISQNDVLEVIEANVFSNLPKLHEIRIEKANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHTVERNSFMGLSFESMIVWLSKNGIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVFQGASGPVILDISRTRIRSLPSYGLENLKKLRAKSTYHLKKLPSLEKFVTLVEASLTYPSHCCAFANWRRQTSDLHPICNKSILRQEVDDMTQARGQRISLAEDDEPSYAKGFDMMYSEFDYDLCSEVVDVTCSPEPDAFNPCEDIMGYDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVHVRHAASIMLVGWVFAFAVALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTRNFRRDFFILLSKFGCYEVQAQTYRSETSFTAHNFHPRNGHCPPAPRVTNGSNYTLIPLRHLAKN
What is the function of this protein?
G protein-coupled receptor for follitropin, the follicle-stimulating hormone.  The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase (PubMed:10527886, PubMed:9364440).  Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase (PubMed:10527886, PubMed:9364440).  Isoform FSH-R3 may be involved in calcium signaling (PubMed:10527886).  Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity).
What are the official names of this protein?
Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
[Isoform FSH-R1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform FSH-R2]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform FSH-R3]: Cell membrane; Single-pass membrane protein.
Protein: SEPT6_HUMAN
Sequence: MAATDIARQVGEGCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQDEKKKLEDKKKSLDDEVNAFKQRKTAAELLQSQGSQAGGSQTLKRDKEKKNNPWLCTE
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  Required for normal organization of the actin cytoskeleton.  Involved in cytokinesis.  May play a role in HCV RNA replication.  Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
What are the official names of this protein?
Septin-6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cell projection, cilium, flagellum. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830).