PharMolix/UniProtQA huggingface dataset:
Protein: SECY_CORGL
Sequence: MSAIIQAFKDADLRKKIFFTIAMIVLYRIGAQIPSPGVDYATISGRLRDLTQDQSSVYSLINLFSGGALLQLSIFAIGIMPYITASIIVQLLTVVIPHFEELKKEGQSGQAKMMQYTRYLTVALALLQSSGIVALADREQLLGAGIRVLSADRNFFDLIVLVITMTAGAVLVMWMGELITEKGVGNGMSLLIFAGIATRLPTDGMNILGNSGGVVFAVVLASVLILVIGVVFVEQGQRRIPVQYAKRMVGRRQYGGSSTYLPLKVNQAGVIPVIFASSLIYMPVLITQIVNSGSLEVSDNWWQRNIIAHLQTPSSWQYIVLYFALTIFFSYFYVSVQYDPAEQAENMKKYGGFIPGIRPGRPTAEYLGFVMNRLLFVGSLYLAVIAVLPNIMLDLGVDAGSAGATPFGGTAILILVSVALTTVKQIESQLLQSNYEGLLK
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SLD7_YEASA
Sequence: MSRKLCTLNFTLSGKQGSLVIRDIQLWSNRPTASKSTSELRGQFIQYVDLAKLPLWVRSTNMNTYRCYSTSATAQAYFKSKLRNANRGIVIELSDKVDQRSQEPAYLIIFRENTELNCFQVDLTMKHEFDGQVTKLKQEIGKTRASVSKEGSIDIIIQQSQQRKIGTKTKVYRNVHINDKRLQFNETLSKLILGGLRLRGISNSITDYQKLYKITFDAAEFTHRDELKRISMGSGEEVSFESLQETVETLLKLFTKS
What is the function of this protein?
Required for the proper function of SLD3 at the initiation of DNA replication.  Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork.  Required for mitochondrial morphology (By similarity).
What are the official names of this protein?
Mitochondrial morphogenesis protein SLD7, Synthetic lethality with DPB11-24 mutation protein 7.
What is the protein family that this protein belongs to?
Belongs to the SLD7 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle pole.
Protein: OBG_GLOC7
Sequence: MQFIDQAEIEVQAGKGGDGIVAFRREKYVPAGGPSGGNGGRGGSVILVAVEHLQTLLDFRYSRHFKAEDGKRGGPNNCTGANGSDRIIEVPRGTMIYDADTEEIIGDLVDNEQRLCIAQGGKGGLGNQHFLSNKNRAPEYALPGLEGEHRRIRLELKLLAEVGIIGLPNAGKSTLISALSSARPKIADYPFTTLIPNLGVVRKPTGDGTVFADIPGLIEGAHEGVGLGYDFLRHIERTRLLLHLVDLTAEDPIKDYQIIQQELEAYGRGLIDRPQIIGLNKLDAVDETVVTQIENDLSQITSDPIFKISAVARIGLDQMLQATWEQLDSNPSEVNISH
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_XYLF2
Sequence: MNDRITLAQAHCQPREKKEHKLGQARLAELLTQVPGWELSNNGHALTRTFQFDNYYRTLAFVNALAFIAHCEDHHPDMNVHYGRAVVCFSTHKIGGISEIDFICAAKTSALYEQGI
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: TCC2_MOUSE
Sequence: DKKLDADISPKPTIFLPSVAETNLHKTGTYLCVLEKFFPDVIRVYWKEKKGNTILDSQEGDMLKTNDTYMKFSWLTVPERSMGKEHRCIVKHENNKGGADQEIFFPTIKKVAVSTKPTTCWQDKNDVLQLQFTITSAYYTYLLLLLKSVIYLAIISFSLLRRTSVCCNEKKS
What are the official names of this protein?
T-cell receptor gamma chain C region C7.5.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HTPG_MYCLE
Sequence: MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPRTVDTSDLHIEIEVDKNTRILTVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATRWSSDGEATYTIESVDEAPQGTSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGEEQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNSDAKIGMQLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQFGKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLLLTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHVKEVRLSTRLTESPACLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLAEGGALENPAKFAGLLADLLSRSM
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPD_BLOPB
Sequence: MNQLRKIIESAFEKKEYISNNNIDSTVNNAVREIMDRLDNGTLRISEKINGTWITHQWLKKAIMLAFHTMDNQLITWGGGVFFDKFPMKFSGWDHTRFENKKLRIIPPATVRYGAYIADNTVIMPSYINLGAYIDVGTMIDTWATVGSCAQIGKYVHLSGGVGIGGVLEPIQTNPTIIEDNCFIGSRSEIVEGVIVEKGAVISMGVFIGQSTKIYDRASGNIYYGRVPAGSVVIPGSLPSKDGRVNTYCAVIVKTVDSKTKNKVKINNLLRDI
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB4M_TITSE
Sequence: MQIKHLITLFFLVLIVADQCSAFLSLIPSLVGGSISAFKGRRKREISAQIEQYKDLQKREAELEELLDRLPMY
What is the function of this protein?
Has a low antimicrobial activity against S. aureus, E. coli, and C. albicans (MICs 120-160 uM).  Has a low hemolytic activity (4% at 160 uM).  Also inhibits the growth of two cancer cell lines on a total of five (the squamous carcinoma cell line H157 (IC(50)=55. 9 uM) and the lung adenocarcinoma cell line H838 (IC(50)=52. 5 uM)).
What are the official names of this protein?
Antimicrobial peptide TsAP-1, Non-disulfide-bridged peptide 4.22, NDBP-4.22.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPX_CORDI
Sequence: MTRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDNGDRLPRPSQISAFLDKYVIGQDDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQKSNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAGYVGEDVENILLKLLQAADFDVQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPNQDFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPEDLVKFGLIPEFIGRLPIVATVNNLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEALQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVAVVRINEAAVRGLQEPEMILHSQKDEEEKTA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: BPPDC_BOTJA
Sequence: QGRPPHPPIPPAP
What is the function of this protein?
This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it.  It acts as an indirect hypotensive agent.
What are the official names of this protein?
Bradykinin-potentiating peptide 13c, BPP-13c.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDHM_CROS5
Sequence: MFVKSTTRHIRIYAAEVHNSELVESDNMLTLDVDPDNEFNWDEDALQKVYRKFDELVEAASGEELSDYNLRRIGSDLEHFVRNLLQNGEISYNLKSRVLNYSMGLPKVESPETEGAYNL
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRH_HAEDU
Sequence: MSKPIYNRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVEMGVEVGVVLGGGNLFRGAKLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAEVNAKLMSAFQLNGICDTYNWSEAIKMLREKRVVIFSAGTGSPFFTTDSAGCLRGIEIEADVVLKATKVEGVYDKDPSKFNDAKLYNTLTYAEVIDQELKVMDLAAFTLARDHNMPIRVFNMGKPGALREVVMGTTEGTTIS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU5C_SOLTU
Sequence: MEQTYEYAWIIPFIPLPVPMLIGAGLILFPTATKSFRRMWAFQSVLLLSIVMIFSIYLSIQQINSSSVYQYVWSWIINNDFSLDFGYLIDPLTSIMSILITTVGIMVLIYSDNYMAHDQGYLRFFAYMSFFSTSMLGLVTSSNLIQIYIFWELVGLCSYLLIGFWFTRPVAANACQKAFVTNRVGDFGLLLGILGFYWITGSFEFRDLFEIFNNLIYNNEVNFLFVTLCAVLLFAGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFRVIPYIMYLISVIGIITVLLGATLALAQKDIKRGLAYSTMSQLGYMMLALGMGSYRSALFHLITHAYSKALLFLGSGSIIHSMETIVGYSPAKSQNMGLMGGLRKHVPITKITFLLGTLSLCGIPPLACFWSKDEILNDSWLYSPIFAIIAWATAGLTAFYMFRIYLLTFEGHLNVHFQNYDGKHKTPFYSISLWGKNGVKKNSCLLTMNNNESTYFLSKTKYPIDKNGRKMTRPFMTIAHFEHKAVSSYPYESDNTMLFPIFVLGLFTLFVGAIGIPFNQEGVNLDILSKWLAPSINLLHPKSNNSQDWNEFLKDAVVSVSIAYFGIFIASFLYKPIYSSLKNLEFINSFVKKGPKRILWDKILNGIYDWSYNRAYIDAFYTRFFVGGIRGLAEFTHFFDRRVIDGMTNGVGVISFIVGEGIKYIGGGRISSYLFLYLAYVSVFLLVYYLLFST
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SSRP_ACICJ
Sequence: MAEPRKSGLISHGIAAQNRKARFNYTIKDTVEAGIVLRGAEVKSLRMGRATLSEAFAGERDGEMYLFNMYIPEYQGGVLSRFDTKGPRKLLLKRKQIDQLLGAIARQGSTVVPLDVHFNPRGLAKVTLGIAEGRKQHDKRQAIAKRDWERDKARILKNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ANR40_HUMAN
Sequence: MNALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIMGVEEEDDDDDDDDNLPQLKKESELPFVPNYLANPAFPFIYTPTAEDSAQMQNGGPSTPPASPPADGSPPLLPPGEPPLLGTFPRDHTSLALVQNGDVSAPSAILRTPESTKPGPVCQPPVSQSRSLFSSVPSKPPMSLEPQNGTYAGPAPAFQPFFFTGAFPFNMQELVLKVRIQNPSLRENDFIEIELDRQELTYQELLRVCCCELGVNPDQVEKIRKLPNTLLRKDKDVARLQDFQELELVLMISENNFLFRNAASTLTERPCYNRRASKLTY
What are the official names of this protein?
Ankyrin repeat domain-containing protein 40.
Protein: CLPX_STRTD
Sequence: MAGNRNEEMVYCSFCGKNQEEVKKIIAGNGVFICNECVALSQEIIREETAEEVLADLAETPKPKELLDILNNYVVGQDRVKRALAVAVYNHYKRINFTESREDNDVDLQKSNILMIGPTGSGKTYLAQTLARSLNVPFAIADATSLTEAGYVGEDVENILLKLIQAADFNIERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTKNILFIVGGAFDGIEDIVKQRLGEKIIGFGQNNKAIDDESSYMKEIVAEDIQKFGLIPEFIGRLPVLAALEQLTVDDLVRILTEPRNALVKQYQTLLSYDGVELEFDQDALEAIASKAIERKTGARGLRSIIEEVMMDVMFEIPSLEDVTKVRITKEAVDGKAAPVLETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PHLA2_SALSA
Sequence: MKMSAEQISEVLKEGELEKRSDNLLQFWKRKTCVLTTDSLNIYADTQKRTKSKELKLQSIKKVDCVERTGKFVYFTIVTTDNKEIDFRCSGDDNCWNAVITMALIDFQNRKAIQDFKTRQDDESGSPGQHESRMARAP
What is the function of this protein?
Plays a role in regulating placenta growth.  May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
What are the official names of this protein?
Pleckstrin homology-like domain family A member 2, Imprinted in placenta and liver protein.
What is the protein family that this protein belongs to?
Belongs to the PHLDA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: MLTD_ECOLI
Sequence: MKAKAILLASVLLVGCQSTGNVQQHAQSLSAAGQGEAAKFTSQARWMDDGTSIAPDGDLWAFIGDELKMGIPENDRIREQKQKYLRNKSYLHDVTLRAEPYMYWIAGQVKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRNYDARRDVVASTTAALNMMQRLNKMFDGDWLLTVAAYNSGEGRVMKAIKTNKARGKSTDFWSLPLPQETKQYVPKMLALSDILKNSKRYGVRLPTTDESRALARVHLSSPVEMAKVADMAGISVSKLKTFNAGVKGSTLGASGPQYVMVPKKHADQLRESLASGEIAAVQSTLVADNTPLNSRVYTVRSGDTLSSIASRLGVSTKDLQQWNKLRGSKLKPGQSLTIGAGSSAQRLANNSDSITYRVRKGDSLSSIAKRHGVNIKDVMRWNSDTANLQPGDKLTLFVKNNNMPDS
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase D, Murein hydrolase D, Regulatory protein DniR.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y268_MYCTU
Sequence: MGTRSKSRTRQLKQSNGCTATTSGASDRRRRARRRTAPAWLREDEWLRHHLPHPPRQLSRCLHRRRRSACHHRYSRRTPKGGLPMTSSLVPISEARAHLSRLVRESADDDVVLMNHGRPAAILISAERYESLMEELEDLRDRLSVHEREHVTMPLDKLGAELGVDIGRV
What is the function of this protein?
Putative antitoxin component of a type II toxin-antitoxin (TA) system; however the expected toxin coding sequence is not found adjacent to this gene.
What are the official names of this protein?
Putative antitoxin Rv0268c.
What is the protein family that this protein belongs to?
Belongs to the phD/YefM antitoxin family.
Protein: FRDD_ECO27
Sequence: MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATP7A_CRIGR
Sequence: MEPSMDVNSVTISVEGMTCISCVRTIEQKIGKENGIHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIFPQKRTLAVTIIPSIVNANQIKELVPELSLETGTLEKRSGACEDHSMAQAGEVVLKIKVEGMTCHSCTSTTEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEIKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSLEGSQQRPSYPSDSTATFIIEGMHCKSCVSNIESALPTLQYVSSIAVSLENRSAIVKYNASSVTPEMLIKAIEAVSPGQYRVSIANEVESTSSSPSSSSLQKMPLNVVSQPLTQETVINISGMTCNSCVQSIEGVVSKKPGVKSIHVSLANSFGTVEYDPLLTAPETLREVIVDMGFDAVLPDMSEPLVVIAQPSLETPLLPSTNDQDNMMTAVHSKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPPVIAEFIRELGFGATVMENADEGDGILKLVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKKDRSASHLDHKREIKQWRSSFLVSLFFCTPVMGLMMYMMAMEHHFATIHHNQSMSNEEMIKNHSSMFLERQILPGLSIMNLLSLLLCLPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITSFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLGGYFVPFIVLVSIATLLVWIIIGFQNFTIVETYFPGYSRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKIPRSKILAIVGTAESNSEHPLGAAVTKYCKQELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNTKNASLVQIDAINEQSSTSSSMIIDAPLSNAVDTQQYKVLIGNREWMIRNGLVISNDVDDSMIDHGRKGRPAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVTIEAADVVFIRNDLLDVVASIDLSRKTVKRIRINFLFPLIYNLVGIPIAAGVFLPIGLVFQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNYELRTRSHTGQRSPSEISVHVGIDDASRNSPRLGLLDRIVNYSRASINSLLSDKRSLNSVVNSEPDKHS
What is the function of this protein?
May function in the export of copper from the cytoplasm to an intracellular organelle.  It may serve as well for the export of other metals.
What are the official names of this protein?
Copper-transporting ATPase 1, Copper pump 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels.
Protein: PTN2B_ARATH
Sequence: METDPANSSSKSPAVVSEKDVLIPEPSENTVGVVQDPVSAEREAHEDSISTEASVAKVDDTQMPASSTGSEPLSKTDDIVPCPPGSSPRESPPSIFSSSGLSSWAKSFKFQQQDPNRTDSGMSAFTRFTSELGLHLPTKGSEEVGDSRSSNTQVGGAFESLTKAVVDSSRGAVKAMQVKARHIVSQNKRRYQEGEFDLDMTYITENIIAMGFPAGDISSGLFGFFEGLYRNHMEEVIKFFETHHKDKYKVYNLCSERLYDASRFEGKVASFPFDDHNCPPIQLIPSFCQSAYTWLKEDIQNVVVVHCKAGMARTGLMICCLLLYLKFFPTAEEAIDYYNQKRCLDGKALVLPSQIRYVKYYERVQNQFDGKVPPERRCMLRGFRLINCPYWIRPAITISNHTDILFSTKKHQKTKDLGPEDFWIKAPKKGVVVFAIPGEAGLTELAGDFKIHFQDSDGDFYCWLNTTLTDNRTMLKGSDFDGFDKRKLPAPGFHVEIVMIEPDNSQPTKSKSDSTQQQSQSSSSADSSKLKSNEKDDDVFSDSDGEEEGNSQSYSTNEKTASSMHTTSKPHQINEPPKRDDPSANRSVTSSSSSGHYNPIPNNSLAVSDIKAIAADASVFSFGDEEEDYESD
What is the function of this protein?
Protein tyrosine phosphatase that exhibits also a weak lipid phosphatase activity towards PtdIns(3)P.
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B, Protein PHOSPHATASE AND TENSIN HOMOLOG 2-b, AtPTEN2b, AtPTEN3.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
Protein: RNAS1_NOMLE
Sequence: MALEKSLVLLPLFVLMLLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSNSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQANCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: YNIB_ECOLI
Sequence: MTYQQAGRIAVLKRILGWVIFIPALISTLISLLKFMNTRQENKEGINAVMLDFTHVMIDMMQANTPFLNLFWYNSPTPNFNGGVNVMFWVIFILIFVGLALQDSGARMSRQARFLREGVEDQLILEKAKGEEGLTREQIESRIVVPHHTIFLQFFSLYILPVICIAAGYVFFSLLGFI
What are the official names of this protein?
Uncharacterized protein YniB.
What is the protein family that this protein belongs to?
To Y.pestis YfeE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXB_COXB2
Sequence: MSNKSVLLIAGEPSGDLLGAHLAQSLKSLEPNLKLAGMGGKRMREAGVEVFINADKLAVVGLLEILRQFRDIRHAMQTLKRYFKKTPPDLVVFIDYPGFNLHMAKQAKKAGIKVLYYVSPQIWAWRYGRIKKIKKYVDHMAVLFDFEEKLYQKENVPVSFVGHPLANAPTPSLSRNEICKQFNLDPDKPIVALFPGSREQEINKLLPMMVQAGKLIQTQIPTVQFILPLALNLALDKIRPFLSPEIKVIQNDISHVLAIAHAAVAASGTVTLEIALQQVPLVIIYKVAPLTFWLGKKLIRLSFIGLCNLVSPEPVAVELLQQDATPQAIADEVFQLLNNHNYRQSIIGKLGHLRPQLDRGNAAQNVAKVIHNLIFS
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: SUB2_TRIVH
Sequence: MQLLNFGLLLLPFVAGDLAPQPEPLLAGPSDVVPGQYIVTLKEGLTSAQIRDHKKWVSSVHRANLDSFAAGASGVETEGIMKHFHIHDLNMYSGGFDEKTVEDLSRNPYVKSVHPDQHVYLAKTVTQRQARWGLGYMSSKGKPVPLHSTLVDYSYDDKAGEGVWAYVLDTGINVNHIEFEGRAILGHNAIPNKPHTDEFGHGTYVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIVRNITDSNRKNKAVINLSISGAKYQPFDDAVEKAFKAGITTVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSFSNYGKLVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSIENLPSPSAVTARVLNLTIPNLVKDAKDSPNRVAYNGIQERKFTLPKYY
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DYR_HUMAN
Sequence: MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
What is the function of this protein?
Key enzyme in folate metabolism.  Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  Binds its own mRNA and that of DHFR2.
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.