PharMolix/UniProtQA huggingface dataset:
Protein: HUTU_STAAS
Sequence: MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIHQAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISFHHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUNS_PECPM
Sequence: MQTVNTQPHRIFRVLLPAVFSSLLLSSLTVSAASSSNDADKLYFGNNKYYLFNNVWGKDEIKGWQQTIFYNSPISMGWNWHWPSSTHSVKAYPSLVSGWHWTAGYTENSGLPIQLSSNKSITSNVTYSIKATGTYNAAYDIWFHTTDKANWDSSPTDELMIWLNDTNAGPAGDYIETVFLGDSSWNVFKGWINADNGGGWNVFSFVHTSGTNSASLNIRHFTDYLVQTKQWMSDEKYISSVEFGTEIFGGDGQIDITEWRVDVK
What are the official names of this protein?
Endoglucanase S, Cellulase S, Endo-1,4-beta-glucanase S.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 12 (cellulase H) family.
Protein: SPAT2_DANRE
Sequence: MDAKLREDLFRRYVASLENRLEEGAAEGGGDRQGAKTEEALISTATALLGSYQADPGQRFRMLRFYDVVENSLRTQRGTSLRTVGTAFATLETICTNLLLFPWKKEYRCIKTFTGPYVYQLQSVLCDSDLRSLLRSMGYSREQELQYNVRDHPGGASHLRQLAFELLLAQAECRLLGEVVSMSRGFASELEAVELRRNTREDAAGCADALRRRDSLTGDLSRLSVRPLDIDRAHLRRSGRPSKSVDVTDSAGHWHQASKPVLKASLSLRKEPLFVDTEEDMKDEIIRPSPSLYPVAAPPSYSPVADFFPIQSPPSEPYSYHLSSLDEVDLYTERGLGGHQTPSRPPSREPRDSWVLKGHMMKCQGCGMGCPSLSSCQRCDMILCSSCHAVDPAPCCGFQDYTKTSRPLDGYMPIKEKLSVYSSAHSHTHPHPHPLPHAQSHSLLLDKAVMSSKLFPSKPVGSGPSPVGSLVSSGSSSSGGERLSVGGSRCGFCNKPGASHTCVNCSKVSCDTCMSLYASDLCTRKNPHHNFVPNHQLNFKSSTISHLVYR
What is the function of this protein?
Bridging factor that mediates the recruitment of cyld to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis.  Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of cyld.
What are the official names of this protein?
Spermatogenesis-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the SPATA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL21_ACIAD
Sequence: MYAVIQSGGKQHRVVEGETLKVELLKAETGSTITFDDVLMVVSGESVQIGAPVVAGAKVTAEVVGHGRHDKIRIIKMRRRKHYRKQQGHRQWFTELKITGISG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: OBG_AYWBP
Sequence: MHFVDEAFNEVFAGNGGHGIVAFRREKYVAFGGPAGGNGGNGGSVIFVGDKGENTLLKLKYQKHLKAPHGINGKNKGQNGANAPHLYVKVPLGTVFYTADNKFLGEILYDQQTLVIAKGGKGGKGNKALATFKNQAPSYSEKGDLGESFKIKTELKVLADIGLLGFPSVGKSSLISAISKAQPKVASYPFTTIKPHLGVVEVDGFSFVVADLPGLIENAHLGCGMGIQFLKHIERCRVLVHILSMESSNPYQDFQTLNQELKQYNPQLLLKKQIIVTNKMDLPDSLKKLTLLKQKIKGQPIIPLSLVSFDNLEILKYKMSSFLQNTPLEVNPNNNNDFKLYTLTDNLKTISVIKESDSVFVVSGNQVEIFFHRTDFNNEESVKRFNRILKKIGMEEQLQKKGAKPGDQVKICDRLFDFL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CAMJD
Sequence: MFIDSVKITLASGDGGKGAVSFRREKHVPLGGPDGGDGGNGGDIIFICDNNTHTLVNFKGKRELRAQNGAGGMGRNKNGKKGENLELVVPEGTQVIDAQTNEILLDLTKEGQRELFLKGGKGGLGNTHFKHATNQRPDYAQPGIKGESRLVRLELKLIADVGLVGFPNVGKSTLISVVSNAKPEIANYEFTTLTPKLGLVDVDEYNSFVMTDIPGIIQGASGGKGLGLAFLKHIERTSFLLFVLDPMREMLLKEQFIVLRKELEKFSDELFGRKFGIMISKSDSVNLGEEFAEQIALNINELENYLKEINNPQSFLIKVSSLEKTGLKELKFMLLEEIKALRNNK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XANA_NEUCR
Sequence: MASNTTVPVITPLAHPEGSKLDFGATVSGVDIENLTDRDFAILRTALFTHQVLVIKSQSHVSPRAQYELTQRFDPLAAPLYGHGNTDSGSVGSKSILHPDLKTIPHQPQVQVIGNGFVPTYEGLSNIQLRHPHHRTFHSTSIPASHDLTHTRFYRWHIDAALYGGVARAPPVVTTLLAVKVPQGRRQTCVYDDGTGDELDVPLGTTAFVSGYKMYDILSETQKAFARSTRVEYAPHPYVWMSSAKSRSTGLGLVSEGKEMPMEELPEIEEDRIQILPMCWRNPVTGKLALQVHPSAVRRLHLEDGTVVEDLKEVREIVYGLQRPGIAPGLVYAHDWEEGDLVIFHNRGTLHSVVGAFAESEVRLFRQCNIAGSEFPMGPEEEEKEEELVHAEQEEGVVEVTKQESLPELRMGAVEVGVAA
What is the function of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966).  Allows xanthine utilization as a nitrogen source (PubMed:15948966).
What are the official names of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase xan-1.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: AROQ_VIBCM
Sequence: MTAKSRILVLNGPNLNLLGLREPTHYGSQTLEQIVATLRDQAQKADIELEHLQSNREYELIEAIHQAFGKVDFIIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHAREPFRHHSYLSDKAQGVICGLGAQGYEFALSAAIRALQAKQ
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RF1_CELJU
Sequence: MKSSILEKLERLKERYEEVSALLSEADVINNQARFRDLSKEYAELEPVVVAYKGYLQLLADIEEAKHLIAEGDADMREMAEEELEGCEARLEPTELELQKLLLPKDPNDEKNCYLEVRAGTGGDEAAIFSGDLFRMYSRYAETQGWRVEILSQSEGEHGGFKEIISLVSGSGVYSKLKFESGAHRVQRVPETESQGRIHTSACTVAVMPEADELEEVNINKADLRIDTYRASGAGGQHVNKTDSAIRITHIPTGIVVECQDERSQHKNRARAMSLLATKLKTMQEEAAHKSISEERRNLVGSGDRSERIRTYNYPQGRVTDHRINLTLYSLDAVMQGDLEPVIGPLANEYQADQLAAIAD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_BORBR
Sequence: MSVAPLKNDVFLRALLREPVPYTPIWLMRQAGRYLPEYNATRARAGSFMGLAQNPDYACEVTLQPLARYPLDAAILFSDILTVPHAMGLGLDFAPGEGPRFAHPVRDESDVAKLAVPDMDSLRYVFDAVRTIRRELDGRVPLIGFAGSPWTIACYMVEGRGSDDYRLIKSMLYGRPDLLHRILEINAEATRHYLNAQIDAGAQAVMLFDSWGGVLADGLFQQFSLAYTRRVVEGLTREREGRRVPVIVFTKGGGQWLEEIAACGCDAVGLDWTVNLGTARRRVADAVALQGNLDPMTLFGGAQAVRAEARRTLDAFGPVGKGGHVFNLGHGISQYSPPEVVSELVDEVHTYSRALHAG
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_PORG3
Sequence: MASFLSRLPQGKVVAALIVLLLVVDQVIKIWVKTTMVLGQSHVVAPWFQIHFVENPGMAFGIELGSKLFLSLFRIVAMGFCIYLLAKLVRKREHTLAFLSCLSLIIAGGIGNIIDSIFYGVIFSGSHGQIAQLFPSGGGYETWFHGRVVDMFYFPLIEGVFPSWLPFWGGEEFVFFHPVFNFADSCISIGLILLLVCYPRTVSLLLDGKKTLPEGTTEDSEPTKRE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_BACCR
Sequence: MSRIGKKILEIPAGVTITVAEDNTVTVKGPKGELTRTFNADMLIKIEENTLTVERPSEQKEHRALHGTTRALIGNMVEGVTEGFARGLELVGVGYRAQKQGDKLVLSVGYSHPVEMTPEAGLEVEVPAPTKIVIKGIDKQRVGEFAANIRAVRAPEPYKGKGIRYEGEVVRRKEGKTAK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NDHI_SYNS3
Sequence: MFGFLKQVGDYTRDAVDAARNLTQGLSVTFDHMKRRPVTVQYPYEKLIPSERYRGRIHYEFDKCIACEVCVRVCPINLPVVDWVMNKETKKKELRNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELAAFDRHSLNYDNVALGRLPTSVTTDPSVQPLRELVYLPAGEVQPHGVSPDRPRAGKLPEQILEELKAAGSMKAAEDERESSSSASNMEESAG
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: MNHE2_STAA1
Sequence: MNQIVLNIIIAFLWVLFQDEDHFKFSTFFSGYLIGLIVIYILHRFFSDDFYVRKIWVAIKFLGVYLYQLITSSISTINYILFKTKDMNPGLLSYETRLTSDWAITFLTILIIITPGSTVIRISQDSKKFFIHSIDVSEKEKDSLLRSIKHYEDLILEVSR
What are the official names of this protein?
Putative antiporter subunit mnhE2, Mrp complex subunit E2, Putative NADH-ubiquinone oxidoreductase subunit mnhE2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HELB4_ASPFU
Sequence: MVEILRFIPLVLLLTLTWRITYELFFSPLRHIPGSLLARLSSKYSILKRVLSDGPQSVQADYQYYGNIYVHRPNGVSISHPDDIRTVLLSPEFRKTKVYEMLDIEGHASIFTTRDPAQASRRRRQIGPYLNHGYLGRMEGLIMKYSVLAIKRKWDRLLEESGGQQVTVNYRDHKQYATFDTIGALAFGREFNALTNDDRTVIRWIEATGLYLGIRKNFPLLKLWPFSRVLRQYRERYERFIAYSKESVTRRKNLLSTVGERPMDLLQAFIDAEDPENPHVKMTADEVMTESIAMQLAGSESTSFVTSWVIHLLTLYPQHLAKVTEEIRSQFSPSHLITFAECRDKLPYLEACVYETLRYSPITSGFLPRISYTKGLTIQGHYIPPGVEIAINLHGAHINKDVWTNPHLYDPTRFLGDDQAKRNVFAFSYGHRNCIGRNLAMMEIMIIIANILKEYDIALPEDSVHGPWNVDALGRPRIMPTRSALFTTPKYPERDCRLVVSRRQ
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
Cytochrome P450 monooxygenase helB4, Helvolic acid biosynthesis cluster protein B4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: 2ABG_MOUSE
Sequence: MGEDTDTRKINHSFLRDHSYVTEADVISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRTFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYESDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
Protein: YNB3_SCHPO
Sequence: MAYPGQFGNYGNPETYRQNVAGNIASYGGPEIDTQLAAQMNAQMYIQQGSAMAPQPRRARRHKDAHAYDMSLTDAEPALAPVMSPAIPPSMNYPTPSTPSVLPESFSNDTNLLDPAALPSAPEVRYEDQQLFKNQIFNTMEKGSPPMSTTDFVGYEQGNSSSKFVQFTSYAIPATNDVCNASGIPLGMIVQPFAELRPDEAPVPVVDNTNSNPPRCKKCRGYINPFIQFTMASSKWTCNLCGSENSFNDDGFNPLVGSQHDGVESRPELNVGTIDFKVGKDYWIKEDPPKPARFVFMIDVSYEASSKGLPKVAAEAIRNILYGPVPLDPNVKIAIVCFDRSVNFFNLSPNLEQPHMLAASDLENPFVPFSSGLFVDPIASKVVIERLLDSFPAIFQDVKIPEPVVGNALEVVKLLLKETGGKAFVFVSALPTMGLGKLRHREDQRLYGTSDEKNLWNTQDKWYTSLADEYVTAGIGVDIFFTATAYVDVATVGSVATLSGGQIYHYSNFVADRDGSRLKQDLFRSVTREQGYRVMLKTRCSNGLRVSKYLGNFLQRTPQDIEFGSLDADKSVTVLFSYDGKLNGALDAHFQTAVLYTTPSGERRVRVVNYCCAVTSKSYDTISLAIVEPIVAVLAKIASTNIAAGSLKDTSVRLVEGVVKILSSYRKVAANRLTPGQLVLPKNLVLLPILILAVLKSSAIRSGSIHSDIRVSQLREVRAAPIQELMLNLYPNIYALHQLQPTDCLPDPENTGCLPINMPLCVRASRKFIEDGGAFLIVTGQKSYLWFHQRTSPLLLQDLLGVESLEDIDSLKALELPTLDTVLSVQVRNLLSSLRMQFPSMALHPQIVRQGLDGSEGEIFSTLVEDNTREGFGYLDFLTKIHESLHTQGYK
What are the official names of this protein?
Uncharacterized protein C4.03c.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Protein: MURF_MYCBO
Sequence: MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGDVVLVKASNAAGLGAVADALVADDTCGSVRP
What is the function of this protein?
Involved in cell wall formation.  Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
What are the official names of this protein?
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase, D-alanyl-D-alanine-adding enzyme, UDP-MurNAc-pentapeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUDA_HALS3
Sequence: MTLDVTGLDVELAGTRILDDVHASIRDGHLVGVVGPNGAGKSTLLRAMNGLITPTAGTVLVAGDDVHALSSAAASRRIATVPQDASVSFEFTVRQVVEMGRHPHTTRFGTDTDTAVVDRAMARTGVAQFAARDVTSLSGGERQRVLLARALAQAAPVLLLDEPTASLDVNHQIRTLEVVRDLADSEDRAVVAAIHDLDLAARYCDELVVVADGRVHDAGAPRSVLTPDTIRAAFDARVAVGTDPATGAVTVTPLPDRTSAAADTSVHVVGGGDSATPVVRRLVSAGASVSVGPVVEGDTDHETARRVGCPCTSVAPFTRLEDTTAASATRADIAAADVIAVPVAAAARPGVRGLLTGAVPTLAVGDAAGAPEWADRLVACDAVVSAVGALADTPSDGV
What is the function of this protein?
Required for corrinoid utilization.  Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Cobalamin import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL5_ZYMMO
Sequence: MAKAYVPRLKKQYDDEIIKAMTEKFGYKNAFEVPKLTKIVLNMGVGEATQDKKKVDQAAAEMELIAGQKPVVTRAKKSIAQFKLREGMPIGVKVTLRRERMFEFLDRFLTIALPRVRDFRGLNPKSFDGRGNYATGIKEQLIFPEISYDQVSTIRGMDVVVATTAKTDEEARELLRLFGFPFPADTTQKKAA
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: KDSA_POLNA
Sequence: MKLCGFDIGLDQPFFLIAGPCVVESEQLQMDTAGTLKEITASLGIPFIFKSSYDKANRSSGTSFRGPGMEKGLQILAKVKRELGLPILTDVHSEAEITAVAAVVDVLQTPAFLCRQTDFIHAVAQSGRPVNIKKGQFLAPGDMKNVIDKARAAAREKGLDEDRFMACERGASFGYNNLVSDMRSLAIMRETRAPVVFDATHSVQLPGGMGTSSGGQREMVPVLARAAVAVGIAGLFMETHPDPANAMSDGPNAVPLKHMKALLETLLELDRVTKKNGYLENSFSA
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_PSEA7
Sequence: MTQISERLLVQAHLAAKQPRVLSEQESAEHRAAIAAELKAQNAVLVAHYYCDPVIQALAEETGGCVSDSLEMARFGNQHPAQTVVVAGVRFMGETAKILNPEKRVLMPTLEATCSLDLGCPVDEFSAFCDQHPERTVVVYANTSAAVKARADWVVTSSCAVEIVEHLMDNGEPILWAPDQHLGRYIQRATGADMLLWDGACIVHEEFKAKQLEDMKALYPDAAILVHPESPESVVALANAVGSTSQLIRAAQTLPNSTFIVATDRGIFYKMQQLCPEKTFVEAPTAGNGAACRSCAHCPWMAMNTLERTLACLREGSGEIFVDPALVPRAVRPLKRMLDFTQAARLRLAGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIF1B_DANRE
Sequence: MMEYPNQSGFRQRKLLPQVRMRGSAMEPSDPTQLFDDTSSGVNKHEPGRVGKSPDVFSGQNLLSDPMSNLAMAYGSSLASHGKEMMDKNLDRFIPISKLKYYFAVDTVYVGKKLGLLVFPYMHDNWEVNYQQDTPVAPRFDINAPDLYIPVMGFITYVLVAGLALGTQNRFSPEILGIQASSALVWLIIEVLAVLLSLYLVTVNTDLTTIDLVAFSGYKYVGMIVGVVAGLLFGRTGYYLALLWFCASIFVFTIRTLRLKILSEAAAEGRLVRGTKNQLRMYLTMAIAAAQPVFMYWLTFHLVR
What is the function of this protein?
Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity).  Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity).  Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (By similarity).
What are the official names of this protein?
Protein YIF1B, YIP1-interacting factor homolog B.
What is the protein family that this protein belongs to?
Belongs to the YIF1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus.
Protein: URE1_RHILO
Sequence: MARISRAAYAQMYGPTVGDKVRLADTELFIEVEKDLTIHGEEVKFGGGKVIRDGMGQSQVSRAQGAVDTVITNALVVDAGAGIFKADIGLKDGRIAAIGKAGNPDTQDGVTIIIGPGTEIIAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGGTGPAHGTLATTCTPGPWHMARMIQSFDAFPMNIGLSGKGNASLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADDYDVQVMIHTDTLNESGFVENTVAAIKGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSSTNPTRPYTVNTLAEHLDMLMVCHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGALPQETGDNDNFRVRRYIAKYTINPAIAHGLSKDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMGDPNASIPTPQPMHYRPMFGAYGKARTNSSVTFVSKAALESGLHGRLGVEKQFVAVENTRGGIGKHSMVLNDATPHVEVDPETYEVRADGELLTCEPATVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUNIP_MOUSE
Sequence: MRHRGPEEEACGVWLDAAALKRRKMQTHLIKLGTKMLPLLPGERKPNDPFTQRRGTRQTSIASFVTLQSGMASGGNQKNIFSLKENQTNKECKRTQLDCLDDGLLSPLVTSAPADIQEAGHPRSPQISGCQGLEMSSLTMMSLTQPDVLMGTGESKGPLDSSFSQYLERSCLLDQREAKRKGEGLRESKTDCPGMGSHIRPPGSKCHQPLDKAEMGKRGPTKENRQAPVHLQTYRSGSCSRKKTLLVTESPCPLSLFPWDSERSDRDSWSQLFTEDSQGQQVIAHNTKMPFRDVTNARNQGSGQFPDSPQAQGQDGPAQLHLQSYLLFTQDSEGNRVIRH
What is the function of this protein?
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination.  Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair.  Inhibits non-homologous end joining (NHEJ).  Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
What are the official names of this protein?
Aurora kinase A and ninein-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the AUNIP family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase.