PharMolix/UniProtQA huggingface dataset:
Protein: DDL_LACLA
Sequence: MSKETLILLYGGRSAEREVSVLSAESVMRAVNYSRFVVKTYFITKGGEFIKTQEFTDKPAEEEKLLTNDLAESYPKISPAAIYEKAAVVFPVLHGPMGEDGSIQGFLEILRLAYVGPNILSASSTMDKLLAKHVFEAVGVPQVPYVAAFADENQGEIAQEVVEKLEFPVFVKPANMGSSVGISKVDDLADLQPALSEAYKYDNRVVIEQGVDAREIECAVLGNNSDVSATLPGEVVKDVEFYDYNSKYIDNKIQMDIPAKVPADLAQKMQEYAIKAYKAVNGTGLSRCDFFVTKDGNVYLNEINAIPGFTQWSMYPLLWENMGLSYSDLIEKLVDLAKETFETRENHLL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDX28_MOUSE
Sequence: MALAGPSRLLALAVRLLLEPRRNLVVRGSDQSLPVVRVPRALQRRQEQRQSGRGSLQRPVLVRPGPLLVSARRPELNQPARLTLGRWERAPLASRGWKHRRSRQDHFSIERVQQEAPALRNLSSRGSFVDLGLEPRVLLALQEAVPEVVQPTSVQSKTIPPLLRGRHLLCAAETGSGKTLSYLLPLFQRLLRGSDLDSRSFTAPRGLVLVPSRELAEQVQAVAQSLGGYLGLQVIELGGGLGMSRLKLQLYRRPAADVLVATPGALWKALKSQLISLQHLNFIVLDEVDTLLDESFLELVDYILEKSPIAESPAELEDPFNPKAQLVLVGATFPEGLNQLLSKVTSPDSLTTITSSKLHCLMPHVRQTFMRLKGADKVTELVQILKQQDKASKTEPSGTVLVFCNSASTVNWLGYILDDHKIQHLRLQGQMPASMRAGIFQSFQKGSQNILVCTDIASRGLDSVHVEVVINYDFPPTLQDYIHRAGRVGRVGSEVPGSVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVGDPLPQKA
What is the function of this protein?
Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function.  May be involved in RNA processing or transport.  Has RNA and Mg(2+)-dependent ATPase activity (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX28, Mitochondrial DEAD box protein 28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion matrix. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids (By similarity).
Protein: LMO1_YEAST
Sequence: MKHNRQMPDESLENIKVLLNPKLGKPVKSLTSAQSKACYHTLISNKNLNKTSDEYEKLLANYILLCDEKYLCKTVIPDSRFWAILCDNCQKLRSETLVANLIRIFNVALKCQDSNKNEVIVSICHISRENSQLIGILLQLLSQRPIHIPLFTDTILCITLFLKCSLTLCETSLSHAVEFVPRILILLFQYNFPASMSELLYIEDLQPLILEEFVPLKQRLINFLSSVSIDDYSCSLKADLLTAIKDNSVFQKGLEMEMGDLPSINLLNAYDTFTFLNSPNGSFKRLYTEQLLFGENDFPLYEAIFKLSDQFRRLFNLSGKKENQYSDSERDLKLQIATAVLNRQTCFYKTLELFLRFWIESLAKSQSDLVSLLNLAIITLKYVCLSSSDLEAAIQTKSLLKTQVVALDSMRYKFARTLQLDSIKKEQYRTWSSSIASFDTMLSGQVRDYVRHQRLLQLQKGTWVYAENPLNPEAGTPKVYFLIVSDNHANLLAREFETQTNDLPYLFDNKILTSPGSEALANGRTKVVVLKHITSFKSIELTTPSRRTSSNVYIKLDEANVYTGVELKDRNDRTVLKFYLDTEEGRYIWLDGLKLISPFQHEDISEDTKEQIDTLFDLRKNVQMINLNVRQDIIVPPPEPSDEDEDEEFYNLETLKKVTQNFYFD
What is the function of this protein?
Forms a transiant heterodimeric complex with DCK1, that acts as a guanine nucleotide exchange factor (GEF) for the small GTPase RHO5 (PubMed:25598154).  DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death (PubMed:25598154).  The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy (PubMed:25598154).  The DCK1/LMO1/RHO5 signaling module also plays a role in cell wall integrity signaling (PubMed:25598154).
What are the official names of this protein?
ELMO family protein LMO1.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Quickly relocates to mitochondria under oxidative stress.
Protein: NOP10_SULIY
Sequence: MKWKMKKCPKDNTYTFKDICPVCGSKTMIPHPSRFSPEDKYVKYRIELKKGVKLNC
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: METXS_BURP0
Sequence: MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPATGTPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGDLSAALAHTKAKYLIASFMTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y032_MYCGE
Sequence: MKTIHKLFLGLCLPATLGPLLGIVVTNTDQSIKFTSKSNSINKNNQNKELALLRDNLMNEAKVDEPLSFEKRFENFKNKYSDIHSLNNSVFSLHDVYDLLGGFKQSLTTFFDEVIAQQQKIKDADKIFPSTKDNPPKEENPNVLDTLANYQGAGFFPSLGKNGFNLPEAVFQNFTDFRINDYKIKNFNVDLVSENDIIKHDKVRYAFEVKFNIALVLSINKSNVDFDFDFILKTDNFSDIENFNEIFNRKPALQFRFYTKINVHKLSFNGSDSTYIANILLQDQFNLLEIDLNKSIYALDLENAKERFDKEFVQPLYQKRREAKLAWEEEQRRIAEEQRRQEEERARILKELKEKAEKDKRVKEAQNNLQKALGNLDTFFNFFSSGQDRVLLGFDPNKYNVQTREGLFKALQISYSNFKTWTFYISLLGWKEGSVKLLKKPIWNALRDDKAFQYAFGLGPNTSEQQLGRVTLPGYGYEGIRMSDWLRWALGYYTSFTLSPPKNVEANLIGDANDKKHIWISPHTFKLNREYGDGERFKGKAYRFKLSISFELEGHLTAHWWTIAFRGSIPGSWSGKLRVTHEFDGDVPYYRLHTTPPQYRLTDDMKLLFVPHSIQRVTAVGNESINGLLRSQNLHNLERQSYEATAPIDLISYMLYAISDKKPPQK
What are the official names of this protein?
Uncharacterized protein MG032.
What is the protein family that this protein belongs to?
Belongs to the MG032/MG096/MG288 family.
Protein: RL20_MYCBT
Sequence: MARVKRAVNAHKKRRSILKASRGYRGQRSRLYRKAKEQQLHSLNYAYRDRRARKGEFRKLWIARINAAARLNDITYNRLIQGLKAAGVEVDRKNLADIAISDPAAFTALVDVARAALPEDVNAPSGEAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ACTB_BOSMU
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPEANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMAIAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIANRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells.  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction.  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.  Part of the ACTR1A/ACTB filament around which the dynactin complex is built.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: MPP4_RAT
Sequence: MRTVCLVKNQQPLGATIKRHEITGDILVARVIHGGLVERNGLLYAGDKLVEVNGVPVEGLDPEQVIHILAMSCGTIMFKVIPVSAPPVSSQTTVYVRAMIDYWPQEDPDIPCMDAGLPFLKGDILQIVDQSDALWWQARKISDIAICAGLIPSNHLLKRKQREFWWSQPYQPHTCLKSTRSKEEFVGDGQQFFIAGFRQQHANMRCTCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQLIGCNPSCFQSAVPHTTRSPKSYEMDGREYHYVSRETFESLMYGHRMLEFGEYKGHLYGTSVNAVLAVLDEGKICVMDLEPQDIQLARTRELKPYVIFIKPPSMSSMRHSRRNAKIITDYFVDMKFKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQDARAQLLSAIQKAEEELQWVPEAWVSPGAES
What is the function of this protein?
May play a role in retinal photoreceptors development.
What are the official names of this protein?
MAGUK p55 subfamily member 4, Discs large homolog 6, rDLG6.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized at photoreceptor synaptic terminals in retina.
Protein: HYI_DANRE
Sequence: MAPLKFCANISWLFTELPEFPQRMRAAASAGFRAVEAAWLYNTDLKELKTAKEETGLEFVLINTPPGDASAGDLGLAAVPGREQEFRQGLDLAVQYAKALDCTRIHLMAGRVPAGSERCALALQMEDTFVHNLKHAAGVLDKEGLLGLIEPINSRITDPRYFLHSPHQAAEILQRVDHPSIKMQMDIFHWQIMDGNLTHNIRRYLPMTGHIQIAQVPDRHEPDSPGELNFSFIFRLLEELDYQGFIGCEYKPQGSTEAGLEWLRKYWRSRNGGERD
What is the function of this protein?
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
What are the official names of this protein?
Putative hydroxypyruvate isomerase.
What is the protein family that this protein belongs to?
Belongs to the hyi family.
Protein: RS14_ARTS2
Sequence: MAKKSMIAKNEQRKVIVERYAAKRLELKKALVDPASTDEAREAARLGLQKLPRNASPVRLRNRDIIDGRPRGTFQKFGISRVRFRDMAHRGELPGITKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: FPPS_BOVIN
Sequence: MNGDQKLDAYAQERQDFIQHFSQIVKVLTEEDIGHPEIGDAITRLKEVLEYNAIGGKYNRGLTVVITFRELVEPGKQDPDSLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQTCWYQKPGIGLDAINDAFLLESSIYRLLKLYCREQPYYLDLIELFLQSSYQTEIGQTLDLITAPQGNVDLGRFTEKRYKSIVKYKTAFYSFYLPVAAAMYMAGIDGEKEHAHAKKILLEMGEFFQIQDDYLDLFGDPSMTGKIGTDIQDNKCSWLVVQCLQRASPEQRQILQENYGQKEAEKVARVKALYEEMNLSAVYMQYEEDSYNHIMGLIEQYAAPLPPAIFLGLAQKIYKRKK
What is the function of this protein?
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones.  FPP also serves as substrate for protein farnesylation and geranylgeranylation.  Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).
What are the official names of this protein?
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PEA
Sequence: MTITPPPSDTEVSVLENKNLGRITQIIGPVLDVVFPPGKMPYIYNALIVQGRDTVGKQINVTCEVQQLLGNNRIRAVAMSATDGLKRGMEVIDTGAALSVPVGGATLGRIFNVLGEPIDNLGPVDTRTTSPIHRSAPAFIQLDTQLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESRVINEKNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTEMGTLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDMIAILGLDEVSEEDRLTVARARKIERFFSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDSLPEQAFYLVGNIDEATAKATNLT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: HA13_MOUSE
Sequence: MGAMVPRTLLLLLAAALAPAQTRAGPHSLRYFETVVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRDEPRVRWMEQEGPEYWERETQIAKGNEQSFRVDLRTLLRYYNQSEGGSHTIQRLSGCDVGSDWRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERDRAYLEGTCVEWLRRYLELGNATLLHTDSPKAHVTHHPRSKVEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAVAIIGAVVAFVMMMRRNTGGKGGDYTLTPGSQSSEMSLPDCKA
What is the function of this protein?
Involved in the presentation of foreign antigens to the immune system.
What are the official names of this protein?
H-2 class I histocompatibility antigen, D-K alpha chain, H-2D(K).
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: LPXK_CHLTE
Sequence: MHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGGTGKTPLVDWIVKFYEASGIATAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAARNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQHRKIARDLDIVVVNAGAPEEIDAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHVDGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEAKRQGLVPVTTEKDWFRIADEPELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MTGA_BURO1
Sequence: MVAVSGTQRTRTVSLARWAVYAGSVFAGAWLATQLFYLAQIALWLFVNPGSTAFMRTDAWWLSRDTPPAQIRHQWVPYDQISRNLKRALIASEDSTFATNNGYDVDAILQAWEKNKARGRIVAGGSTITQQLARNLFLSREKSYIRKGQELIITWMLETVLDKERIFEIYLNSVEWGRGVYGAEAAARYYYKIPASRLGAWQSARLAVMLPKPRWFDAHRGSAYQAQRAAVIARRMGAAELPQSE
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
Protein: CH10_CLOBK
Sequence: MNIRPLGDRVVIKRVEAEETTKSGIVLPGAAKEKPQVAEVIAVGPGGLVDGKEVKMELKVGDKVLFSKYAGNEVKIEGEEVTILKQDDILAVVEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_NOSS1
Sequence: MSIPEITQTLLQAKKDKGLSFADLEATLGRDEVCIAALFYRQASASEEEAKLLVEALGLDSSYIKHLTEYPVKGLGPVVPTDPLIYRFYEIMQVYGFPIKEVIQEKFGDGIMSAIDFTLDVEKEADPKGDRVKITMSGKFLPYKKW
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: SMS2_PELRI
Sequence: MLGSAGTLLLLLLAWGARALSQPDDNRITTGRNQDLNAIQQDLLLKLLSGWTDSRESNLVEVERNVPDPPEPKIPPSVKFPRLSLRERKAPCKNFFWKTFTMC
What is the function of this protein?
Somatostatin inhibits the release of somatotropin.
What are the official names of this protein?
Somatostatin-2, PSS2.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPE_BUCAP
Sequence: MSKNPYEIEIIQKTAPYHPDPTMIFNHLCASRPGTLLLETAEVNKKRDLESIMIIDSAMRISSEDNSVKLTPLSINGTDILSTLKKTIPKKIEIYEKNNSTILVFPKIKKNIDEDKKLFSLSVFDAFRLMIRIFENREKKSKAMFFGGLFSYDLISVFESLPKLKGNQKCSNFCFYLAETLLVLDHQKKTCLIQNSLFSKNLKERKRIKKRSVEIERKLNEKLKLIPKTKIKDINLTSNMNNFEYGTIIKKLQKLIQKGEIFQVVPSRKFYLPCPNPLSAYQKLKKSNPSPYMFFMQDQDFTLFGASPESSLKYDEKTRKIELYPIAGTRPRGKTEDGNLDLDLDSRIELEMRTNHKELAEHLMLVDLARNDLARICKPGSRYVSDLVRVDRYSHVMHLVSRVIGELREGLDALHAYASCMNMGTLTGAPKVRAMQLIAEHEGEKRGSYGGAIGYFTDLGNLDTCITIRSAYVEKQVATIQAGAGIVYNSIPENEVNESLNKAQAVINAIKNAHY
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: PYRF_THEFY
Sequence: MAAPIAVALDAPDVETASRWAAAVAPHVSTLKVGLELYLRYGPAVVEAVRGARETALFLDLKLHDIPATVAGAARSVAGLAPAFLTVHAAGGADMVRAAVEAAPETRIAAVTVLTSLDEAALGAVGMRGPARDAVRRLAVLAVEAGARALVCSPQEAAMVRAEVGPDVTLITPGVRPAGAAQGDQARVATPEAALAAGADLLVIGRPITRAPDPGAAAAALAAELQKTGASPS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CYSH_YERE8
Sequence: MSQFNLNELNALPKAEQAAALALVNGQLEHLTAQERVSWALENLPGEFVLSSSFGIQAAVCLHLVTRQQPDIPVILTDTGYLFPETYQFIDSLTEKLQLNLQVFRAQQSPAWQEARYGKLWEQGVEGIERYNDLNKVEPMNRALETLGAQTWFAGLRREQSGSRAKLPVLAIARGVFKLLPIIDWDNRQVYQYLTQHGLSYHPLWEQGYLSVGDTHTTRKWEPGMSEEETRFFGLKRECGLHES
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_CERS1
Sequence: MTTAAIIVAAGRGTRAGGDLPKQWQPLAGRPVLAHTLAAFRAAAGVSRTLLVIHPDDRARAEALPGVAEGKVELVEGGASRDASVRNALEALAGAGIERVLIHDGARPLVAPGLIARTLAALETAPGAAPAVPVSDALWRGEGGRVVGTQDRTGLFRAQTPQAFRYEAILAAHRAHPGGAADDVEVARAAGLEVAIVEGCEDNLKVTYPGDFARAERLLALAAGL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: GPAT3_DANRE
Sequence: MEGAWDVAFVLLHVWMSIVAGLIVLPAMFGVSLGFTDIYIKLLVKTLEWATLRIQRGQKEQPTLPLQLANGIIEKDDGSMEEEIVELRRSHPKNLAEGNFTLCDAFYFCKKGIENIVEDQVTQRFSSEELASWNLLTRTNNNFRYISVRLTIIWGLGVFVRYCVLLPLRITLAVIGLSWLVIGTTLVGFLPNSKVKNWLSDLVHITCYRICARGLSATIRYHNKENRPKKGGICVANHTSPIDIVILANDGCYAMVGQVHGGLMGVIQRSMVRSCPHVWFERSEMKDRHAVAKRLKDHISDKTKLPILIFPEGTCINNTSVMMFKKGSFEFGGTIYPVAIKYDPRFGDAFWNSAKYNMVSYILRMMTSWAIVCNVWYLPPMTQQDGEDAVHFANRVKSAIAHQGGLVDLSWDGGLKRSKVKESFKEEQQKMYSSMIVGLDSHEATVGPA
What is the function of this protein?
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone.  Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.  Protects cells against lipotoxicity.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Lysophosphatidic acid acyltransferase theta, LPAAT-theta.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PDXT_NATPD
Sequence: MLKAGVIAVQGDVAEHADAIRRAADRHGEDCTVESIRSAGVVPECDLLLLPGGESTTISRLLAEEGIDEEIEAFAAAGKPLLATCAGLIVASRDAKDDRVSTLDILDVSVDRNAFGRQKDSFEAAIDVEGLDEPFPAVFIRAPLIDEVDAAVETLAAVDDRPVAVRQDNVVGTSFHPELTDDSRIHGLAFFS
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: GRPE_PEWBP
Sequence: MQEFMNFEECSKQNTNNCKQHEKNIDENNCSCKEKKVQSKKVSSDHSSSEDNASSDINSNKAETLTLNCGDQSDNKNSISDIESNKFIPNENDFQMLKKQLNDLKAENVNLKRDLQEAHQQRTNDNLKYLADFDNFKKRITVQTNREIKYALTDFIKNILIPLEQFEKVLEMPKVDDSVKSFLLGFKMIHKQVKDILQKEGVEEIKALGVKFDPNFHYALEKISDLKQPNGINVLVLQKGFLYKDLVIKPAMVKVNEWSDKNND
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSA2_CHRVO
Sequence: MKPVDSLSGLSEHLSVHALCRRFGAFTALDQASLSIRKGEFVCLLGPSGCGKTTLLRLIAGLDLPDAGAIRLSGRDITRTAPAKRDYGIVFQSYALFPNLTVADNIAYGLTPRRDKAGHAHRVRELLDMVGLPGSEGKYPSQLSGGQQQRVALARALATSPGLLLLDEPLSALDARVRDKLREELKGLQRRLGVTTMMVTHDQEEALSIADRVVVMNAGRIEQTGTPAEIYRSPASRFVAEFVGDANWLPAERRGGREAAVGGCVLSLARDLPDAEALTLFIRPEDVIVKPRWAPAANTLLARVEDVSFGGAMTRLRLRPEGMPGLILRAEICPSMLNRQPLVPGEIVPVELPAAQLRAYPGEAAC
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA 2, Sulfate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.