PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_CALS4
Sequence: MKQKSIEMLVQGASSLGITLEMFHVEHFQKFYSLLLEWNQKMNLTAITEEEEVVIKHFLDSLSVIKSGKIKGGEKVIDIGTGAGFPGIPLKIVFPEIGLTLLEASKKKVNFLNFLSQVLLFEGIEVIHGRAEELGKVERFREKFDIATARAVAPLNILLEYAVPFVRVGGHFIAMKGRDIEEVYQCKNALEELKCEIEDVIEVRLPFSDILHHLIVVKKVDVLPSKYPRREKAIRTKPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_ALIFM
Sequence: MALTKADLAETLFEKVGLSKRDAKETVEVFFEEIKQALESGEQVKLSGFGNFDLREKSERPGRNPKTGEDIPISARRVVTFKPGQKLKARVENLPVEK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NEIL2_PONAB
Sequence: MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQCLWLQDTQVNGKKLFLRFDPDEEMGPPGSSPPPEPPQKEAQKEGAADPKQVGEPSGQKTPDGSSQSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNEFSRAKQANKRGDWRDPSPRLVLHCGGGGFLAFYNCQMSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKFQGRPQRTQVYQREQCPAGHQVMKEAFGPQDGLQRLTWWCPQCQPQLSEEPEQRQFS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles).  Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAA_CAMC5
Sequence: MFCEFAIIGTTASGKSALALQIAQEFSGVILSLDSLALYKQIDIASAKPSRKELASVKHFGVDEIYPNENFSVGMFFKIYERAKDYALNADCPLIITGGSGFYLRSMLSGLAPDVPKCDKALSNDEIYALAARIDPEFCAKFSPNDSYRLEKWYQIYKFSGAVPSTWLRENTSEPVIKELAIFEILWSAQAIRERIQRRTQAMFEAGLLEEAKFLFDTYGRELKPLRSIGLKECADFFDAKISREELASLICTHTAQLAKRQRTFNRSQFSKIFIGEPDAAREKIKGFLKNQAKRP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MSRB_PSEAB
Sequence: MSKIDKPLDSWREELTEEQFHICRLGGTERAFSGEYHATKTPGIYHCTCCGTALFDSDAKYDSGSGWPSYFQPVDAEAVRELDDFSHGMHRIEVRCGRCDAHLGHVFPDGPRPTGLRYCINSASLKLVPRES
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: SYL_PARL1
Sequence: MSTRYNARAAEPKWQKIWEERGDFLMRDDADGKPKYYVLEMFPYPSGRIHMGHVRNYTMGDVIARYKKARGFNVLHPMGWDAFGMPAENAAMEKNVHPKGWTYDNIAAMREQLKAIGLAIDWSREFATCDPEYYGHEQALFLDMLEAGLVSRKKSMVNWDPVDNTVLANEQVIDGRGWRSGALVERRELTQWFLKISDFADELLEGLDTLDRWPEKVRLMQKNWIGRSEGARVFFELENAPDGNTKLEIFTTRPDTLYGASFCALSPHHPLTQSLAKDNPALTDFIRECDRIGTSEEAIETADKMGFDTGLKARHPFIEGKTLPVYVANFVLMDYGTGAIFACPAHDQRDLDFARKYNLPVIPVVAPKDKQGAELDAFASGLAETGTDAYTGDGVAINSDFLNGLDVQSAKRAAIDRLEAKGIGEGTVNYRLRDWGISRQRYWGCPIPVIHCASCGTLPVPRDQLPVVLPDDVNFSEPGNPLDRHPSWKHVDCPKCGKPASRETDTFDTFVDSSWYFVRFTAPDAPTPTDKALADHWLPVDQYIGGIEHAILHLLYSRFFTRAMKATGHVSLDEPFAGLFTQGMVNHETYRDAEGRWVPPAEVDIETVSGKRVAKRIADGEPVIIGSVEKMSKSKKNTVDPEDIIAKYGADTARWFMLSDSPPERDVQWTDQGAEGAWRFTQRLWRMVTERQEDLAPTGTPMPTAFSEDELTLRRAAHQALAAATEDFENLRFNRAVARVYELANAVSGFTPGTPEGAFAKREALEILVQIVGPMMPHIAEECWEALGHGEPLTAAEWPVADKALLVEDSVTIAVQVNGKRRDELTIARDADRETVERAALALEKVGKAIDGKPVRKVIVVPGKIVNIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RU2A_DROME
Sequence: MVKLTPELINQSMQYINPCRERELDLRGYKIPQIENLGATLDQFDTIDLSDNDLRKLDNLPHLPRLKCLLLNNNRILRISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKLETICLLINPVSTKPNYREYMAYKFPQLRLLDFRKIKQKDRQAAQEFFRTKQGKDVLKEISRKSKMSAAAAIAAEAGNGKGRGSEGGRLANPQDMQRIREAIKRASSLAEVERLSQILQSGQLPDKFQHEMEAVAQNGAGHNGSGAVAMEY
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (By similarity).  Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity).  In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26 (PubMed:27035939, PubMed:24244416).
What are the official names of this protein?
Probable U2 small nuclear ribonucleoprotein A', U2 snRNP A'.
What is the protein family that this protein belongs to?
Belongs to the U2 small nuclear ribonucleoprotein A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KTHY_ECOK1
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGGFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTNWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: CRCB_SHEB5
Sequence: MNNLLLVALGGSIGAVFRYLISIFMIQVFGSSFPFGTLLVNVLGSFLMGVIYALGQMSHISPEFKALIGIGLLGALTTFSTFSNETLLLLQEGDWLKATLNVVLNLSLCLFMVYLGQQLVFSRI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL15_STAAR
Sequence: MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AROK_AERS4
Sequence: MAEKRNIFLIGPMGAGKSTIGRHLAEQLHMEFFDSDHEIERRSGADIGWVFDVEGEEGFRIREEKVIGDLSEQQGIVLATGGGAIKSRETRNKLSARGIVVYLETTIEKQLARTQRDKRRPLLQTEEPPREVLERLAQERNALYEEVADFVIQTDDQSAKIVANQIVKLIGM
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_KORVE
Sequence: MKPEPKVATVEFTGGKSLSFETGKLAKQAHGSAIVRSGQSVVLATACANADPREGIDFFPLTVDYREYTYAGGRFPGGFIKREGRPSEKEILTSRQIDRPIRPLFPEGFRCETQVIAMVLSADSENDPDVCGINGASAALAVSDIPFNGPIGAVRVGLIEGQNIVNPTYDEMRASKLNIMVVGTAEGIVMIESGAHEATEEEVVSAIEFGHGEIKKICAVISKLAKEVGKTKRTVAPVELDQPYLDGLRKKIGADLADALNTEKYPKSESYAKVKEIKSKLKEEIPADDDAALKKLGKYYELLREDIFRQQVTKEKRRPDGRAFDQIRQIWIEVDVLPRTHGSAVFTRGETQALVTTTLGTGDDMQRMEGFEGEAKKRFMLHYNFPPFSVGEVAFLRGAGRREIGHGALAERALSAVLPSEDKWPYAMRVVSDILESNGSSSMASICGGSLSLMDAGVPLKAPVAGIAMGLVKEGDDYAILTDIAGAEDHYGDMDFKVAGTTQGITALQMDIKIGGITAQIMREALEQARRGRLFILDKMNEVIQSPRTELSEFAPRFYTLQIPTDKIRDLIGPGGKVIRGIVEATGVKIDVEDSGKVNVASSDQEAAKKALKMIGDITATAEVGKTYLGTVTRLADFGAFVEILPGTDGLLHISEVAEHRIKDVKDELHEGDQVLVKVLAVDGNRIKLSRKAVLKEQRAKMATEGGGDGGPAPEVEHSEHGAPGGVTFEGGYEGGDEPEVEEGEPNFNRDDAPGSHGATQPHSGGDRPDRGPRPHGGGGGAGRGGRGRRPGGGGGGGRGGHGGRGGGGGGRGRG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRPZ_PSESH
Sequence: MQSLSLNSSTLQSPSMALVLIRPETETTGSSTSSRALQEVIAQLAQELTHNGQLDESSPLGKLLGKAMAASGKAGGGLEDIKAALDTLIHEKLGDNFGASADNASDTGQHDLMTQVLNGLAKSMLNDLLTKQDDGTRFSEDDMPMLKKIAEFMDDNPAQFPKPDSGSWVNELKEDNFLDGDETAQFRSALDIIGQQLGSQQNAAGGLAGDSSGGGLGSPVSNTENSPGSLGDPLIDANTGPASNSNSNGDVGQLIGELIDRGLQSVLAGGGLGTPVSTANTALVPGGEQPNQDLGQLLGGLLQKGLEATLQDAGQTGTGVQSSAAQVALLLVNMLLQSTKNQAAA
What is the function of this protein?
Harpins are proteins able to elicit hypersensitive response (HR) in non-host plants and are required for pathogenicity in host plants.  HrpZ forms ion-conducting pores permeable for cations.  Such pore-forming activity may allow nutrient release and/or delivery of virulence factors during bacterial colonization of host plants.  Also binds peptides, which contain tryptophan and leucine, suggesting a protein-protein interaction between the harpin and a host plant protein, possibly involved in the bacterial pathogenesis.
What are the official names of this protein?
Harpin HrpZ, Harpin-Psph, HrpZ-Psph protein.
What is the protein family that this protein belongs to?
Belongs to the harpin HrpZ family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=Secreted via type III secretion system (TTSS), delivered into the host intercellular space. HrpZ travels through the hrp pilus and it is secreted only from the pilus tip (By similarity). It is found to associate stably with liposomes and synthetic bilayer membranes.
Protein: NOP16_XENTR
Sequence: MGKVKKKRGNTFNYNVDRKKLKRKARKKHAPRIPCEPIRSAWNDGKSVAKNLADMGLAANPNKSLPIRPSQVKDAEEQPGKVIKKPYVLEGLQALASLPSKQTMGISSDMIQYVRHMVENYGEDYKAMARDEKNYYQDTPKQIQRKVNLYKRHHPQDYQALVASRIMQ
What are the official names of this protein?
Nucleolar protein 16.
What is the protein family that this protein belongs to?
Belongs to the NOP16 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HCYE_APHSP
Sequence: MPDKQKQLRVISLFEHMTSINTPLPRDQIDARLHHLGRLPQGELFSCFHEEDLEEATELYKILYTAKDFDEVINLAKQSRTFVNEGLFVYAVSVALLHRDDCKGIVVPAIQEIFPDRFVPTETINLAVKEAANHPDQDISVHVVETGNILDEEYKLAYFKEDVGTNAHHWHWHIVYPATWDPAFMGRMKDRKGELFYYMHQQMCARYDCERLSNGMRRMIPFSNFDEKLEGYSAHLTSLVSGLPYAFRPDGLCLHDLKDIDLKEMFRWRERILDAIDSGYYIDNEGHQVKLDIVDGINVLGALIESSFETKNKLYYGSLHNWGHVMMARLQDPDHRFNENPGVMSDTSTSLRDPIFYRYHRFIDNIFQKYIATLPHYTPEDLTCPGVHVVNVTVNAKVPNVVTTFMKEAELELSYGIDFGSDHSVKVLYRHLDHEPFTYNISVENSSGGAKDVTMRIFLGPKYDELGNRLQPEQQRTLNIELDKFKATLDPGKNVVTRDHRNSTVTVEQSVPVKKLREEGGVAGEYCSCGWPEHMLIPKGNHRGMDFELFVIVTDYAQDAVNGHGENAECVDAVSYCGAKDQKYPDKKPMGFPFDRVIEGLTFEEFLTVSMSCTDVRIKYTDIK
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin E chain, HcE.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: PURA_HELPJ
Sequence: MADVVVGIQWGDEGKGKIVDRIAKDYDFVVRYQGGHNAGHTIVHKGVKHSLHLMPSGVLYPKCKNIISSAVVVSVKDLCEEISAFEDLENRLFISDRAHVILPYHAKKDAFKEKSQNIGTTKKGIGPCYEDKMARSGIRMGDLLDDKILEEKLNAHFKAIEPFKKAYDLGENYEKDLMGYFKTYAPKICPFIKDTTSMLIEANQKGEKILLEGAQGTLLDIDLGTYPFVTSSNTTSASACVSTGLNPKAINEVIGITKAYSTRVGNGPFPSEDTTPMGDHLRTKGVEFGTTTKRPRRCGWLDLVALKYACALNGCTQLALMKLDVLDGIDAIKVCVAYERKGERLEAFPSDLKDCTPIYQTFKGWEKSVGVRKLDDLEPNAREYIRFIEKEVGVKIGLISTSPEREDTIFL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_BIFAA
Sequence: MAEATTNTTTIIARADQHDIDLHKASDRVNFGSIREPIDVPYLLGVQTDSFDWLIGNERWQKRVQEDLENGTNTVPHTSGLDEVFQEISPIENFAQTMSLTFSDPYFEEPRHTVQECKEKDYTYSAPLYVNAEFENGDTGEIKSQTVFMGDFPLQTPHGTFIIGGTERVIVSQLVRSPGVYFDRSQDRTSDKEVFGAKIIPSRGAWLEFEIDKRDVLGVRVDRKRKQSAIVFLMAIGMTKDEIADAFKDYPLVMDALAKETVQTQDEALTDLYRKIRPADTPTPEAGKNLLDSFYFNTKRYDLARVGRYKINRKLGLEKDVNDRSLSREDIIATIKYLVTLHAGETKFPGKRDGQDVDLRVDVDDIDHFGNRRIRQVGELIQNQLRTGLSRMERVVRERMTTQDPEAITPQSLINIRPVNATIKEFFGTSQLSQFMDQNNPLAGVTNKRRLSALGPGGLSRDRASMEVRDVHPSHFGRMCPIESPEGPNIGLIGSLATFGRINPFGFIETPYRKVVNGHVTDEVEYMTADRDAEHVIAQANQELDENGNFVKKQALARVGEEEAVDVPVSSVDYMDVSPRQMVSVGASLIPFLEHDEGHRALMGTNMQRQAVPLIESERPLVGTGAEWRAAVDSGDVILAEKPGVVTYVSADIIRTMNDDGTTSSYKLAKFQRSNQTTCYNQVPLIHDGERVEAGTVLADGPATQKGEMALGKNLLIAFMPWNGYNYEDAVIISQRLVQDDTLSSIHIEEYEIDARETKLGAEEITRDLPNVGEDAVANLDERGIIRIGAEVEAGDILVGKVTPKGETELTPEERLLRAIFGEKSREVRDTSLRVPHGETGTVIAVKEITREDAEEDGDELPNGVNQMIRVYIAQHRKITQGDKLSGRHGNKGVISRILPEEDMPFLADGTPVDIMLNPLGVPSRMNLGQVLELHLGWIAHAGWDISLDPDAEAAWKKYVPQGAEKGAPGTPVATPVFDGVRPETIKGLLSCTLPDRDGNKLVGPDGKATLFDGRTGEPFPKPISVGYMYMLKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLHEMMTTKSDDVDGRVRVYGAIVKGENLPPAGIPESFKVLLKEMQSLSLNVEVLNADGVAIDMKEEDDDPSTSSDDLGFNIGARPDAAAKEDQVAEEPEFQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: VTF3L_MONPZ
Sequence: MDNLFTFLHEIEDRYARTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHPAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFESEKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCINMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLMATALDEKLFLIKKMAEHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCTNYVTKSENMIEMMKERSTILNSIDIETESVDRLKELLLK
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
What are the official names of this protein?
Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviruses A23 family.
Protein: COPK_CUPMC
Sequence: MKQKLMVGAFIAAVSLSAAAVDMSNVVKTYDLQDGSKVHVFKDGKMGMENKFGKSMNMPEGKVMETRDGTKIIMKGNEIFRLDEALRKGHSEGG
What is the function of this protein?
Involved in resistance to copper.  Can bind up to 2 copper ions.  Has higher affinity for Cu(+) than for Cu(2+).
What are the official names of this protein?
Copper resistance protein K.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRMA_VIBPA
Sequence: MATLDVNPQRYQEQLAEKVERLTDMFAPYNVPELEVFESPEQHYRMRAEFRVWHEGEDLYYIMFNQETREKYRVDQFPAASRLINDLMPLLVEAMKDNESLRRKLFQVDFLSTLSGEILVSLLYHRQLDEEWIENAKALKQRLNDEGFNLNIIGRARKMKIILDRDYVIEKLDVNGQSYIYQQVENSFTQPNGKVAEKMLEWAVDCTQESTGDLLELYCGNGNFSLALAQNFDRVLATELAKPSVESAQYNIAANKIDNVQIIRMSAEEFTEAMEGKREFRRLKDNGVDLKSYNCNTIFVDPPRAGMDVDTCKMVQGYERIMYISCNPETLKENLDILSETHNVTRFALFDQFPYTHHMEAGVLLERKA
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: MP2K2_MOUSE
Sequence: MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
What is the function of this protein?
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases.  Activates the ERK1 and ERK2 MAP kinases (PubMed:19219045).  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane localization is probably regulated by its interaction with KSR1.
Protein: DUSB_PECCA
Sequence: MHIGQFQLTNRLIAAPMAGISDRPFRALCHAMGAGMTVSEMLSSNPEVWRSDKSRLRMVHSDEPGIRAVQIAGCDPDEMAAARRINADSGAQIIDINMGCPAKKVNRKMAGSALLQYPDLVKQILSTVVKAVDVPVTLKIRTGWAPEHRNCVEIAKLAEDCGIQALTIHGRTRACLFNGFAEYDSIRAVKQAVSIPIIANGDITDPHKARAVLDYTGADALMIGRAAQGRPWIFREIQHYLDTGELLAPLPLVEVKRLLIEHIRELHDFYGPGKGFRIARKHVSWYLQEHAPNDQFRRTFNAIEDASEQLEALKAYFENLA
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
tRNA-dihydrouridine synthase B.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusB subfamily.
Protein: PURA_SALDC
Sequence: MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPSALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKVEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEYGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_PECCP
Sequence: MNRVILYCRPGFEKECAAEITEKATQHDAYGFARVKENSGYVVFECYQHEDAERLVKTLPFHELIFARQMFVSGELLRDLPPEDRITPIVGMLSGAIERAGELRVEVPDTNESKELMKFCRKFTVPLRAALREHKILLGYEKADRPVLHVLFIAPGCCYVGYSYSNNNSPFYMGIPRLKFPSDAPSRSTLKLEEAFHVFIPADEWDERLGSGMYAVDLGACPGGWTYQLVKRSMMVYAVDNGPMAPSLMETGQVMHHQADGFRFEPPRNNVYWLVCDMVEKPAKVTSLMSDWLIKGWCREAIFNLKLPMKKRYEEVSHNLAVLQERLSENGINAEVHAKHLYHDREEITVHVRRFWSAVPGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_AGRVS
Sequence: MSASESQTQARLLAQALPFMQRYENKTIVVKYGGHAMGDAELGRAFAADIALLKQSGVNPIVVHGGGPQIGAMLTKMGIESKFEGGLRVTDQKTVEIVEMVLAGSINKEIVALINQTGEWAIGLCGKDGNMVFAEKAKKTVIDPDSHIERVLDLGFVGEVVEVDRTLLDLLAKSEMIPVIAPVAPGRDGHTYNINADTFAGAIAGALRADRLLFLTDVPGVLDKNGELFKELSVAQARALIKDGTISGGMIPKVETCIDAINAGVHGVVILNGKTAHSVLLEIFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL37A_OSTTA
Sequence: MAKRTKKVGIVGKYGTRYGASLRKVVKKTEVSQHSKFFCDFCGKYGMKRQAVGIWCCKGCNKTKAGGAYSLNTGGSVTVRSTIRRLREATEK
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: RS11_METPB
Sequence: MAKEPTRVRRRERKNIVSGVAHVNASFNNTMITITDAQGNTISWSSAGAMGFKGSRKSTPYAAQVAAEDAGRKAAEHGMRTLEVEVSGPGSGRESALRALQAAGFTVTSIRDVTSIPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MNMG_XANOR
Sequence: MSDSFYRYDVIVIGGGHAGTEAALASARAGAHTLLLTHTIETVGAMSCNPAIGGIGKGHLVKEIDALGGAMAHAADLAGIQWRTLNASKGPAVRATRCQADRNLYRTAIRCIVQAQPKLTVFQAAVDDLIIHNGTCEADSVRGVITQTGLRFEAPSVVLTAGTFLAGKIHVGDTQYAAGRLGDPPATTLAARLRERPFAIDRLKTGTPPRIDGRTLDYGVMGEQPGDDPLPVMSFMGQVSDHPRQVSCWITQTTEQTHDIIRNALHRSPLYSGQIEGIGPRYCPSIEDKVVRFAEKTSHQIFVEPEGLDVAEIYPNGISTSLPFDVQLALVRSIHGFAQAHITRPGYAIEYDFFDPRGLKASLETKAVGGLFFAGQINGTTGYEEAAAQGLLAGLNAARHVHGLPAWSPRRDEAYLGVLVDDLITHGTTEPYRMFTSRAEYRLQLREDNADARLTGAGREMGLVDDARWARFSAKQEAVQRETARLSALWATPGNALGREVADALGVTVSRETNVLDLIKRPELNYATLMRVPTLGPGVDDAQVAEQVEISVKYTGYLDRQRDDIARQQRHETTPIPEGFDYAGVRGLSIEVQQKLEHVRPQHIGQAQRIPGMTPAAISLLLVHLERARRHRVA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.