PharMolix/UniProtQA huggingface dataset:
Protein: ZDHC6_HUMAN
Sequence: MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR
What is the function of this protein?
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475).  Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232).  Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137).  Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151).  Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (PubMed:26214738).
What are the official names of this protein?
Palmitoyltransferase ZDHHC6, Stearoyltransferase ZDHHC6, Transmembrane protein H4, Zinc finger DHHC domain-containing protein 6, DHHC-6, Zinc finger protein 376.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
Protein: EAF3_YARLI
Sequence: MVLATNSRCLAYHGPLLYEAKILMSYDPSKRGSKAKVEDGLPPTVEIGNVVNTHKRKRGPRASLPAAGATPDGDDSNDKNRHFSPKEGKPDVPADLADENEDKICYYVHYKGWKNTWDEWVGEERVLALNEDNIKLQKELKAAALAAAKKGKDFDALAPPEALSETASPAPTTKRKSMASKDSPAEGPRPVKRRGGLAALEDLEKEDDYLKRKEIALVVPDKLKAQLVDDWEFVTKDHQLVGLPRKVTVVDILKEFKKEAEAKYRPGSADADILNEVVSGIKLYFDRSLGSILLYRFEREQYLQITQSPDHSNKTMSEVYGAEHLLRLFVSLPGLIAMTNMDAQSVAVLKEHLEDFVRFLSTHQKTYFLKEAYTNASPAYEALSKGL
What is the function of this protein?
Involved in deacetylation of histones, chromatin assembly and chromosome segregation.  May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains.  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein EAF3.
What is the protein family that this protein belongs to?
Belongs to the MRG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y517_STRPM
Sequence: MSDKHINLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALVPKFLELIEQTNENRRVALVVDMRSRLFFKEINSTLDSIESNPSIDFRILFLDATDGELVSRYKETRRSHPLAADGRVLDGIRLERELLSPLKSMSQHVVDTTKLTPRQLRKTISDQFSEGSNQASFRIEVMSFGFKYGLPLDADLVFDVRFLPNPYYKVELREKTGLDEDVFNYVMSHPESEVFYKHLLNLIVPILPAYQKEGKSVLTVAIGCTGGQHRSVAFAHCLAESLATDWSVNESHRDQNRRKETVNRS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein M28_Spy0517.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: BRK4_PITHY
Sequence: MSILKKSLFLVLFLGLVSFSICEEEKREAEEEENEDEIEEQSEEKKRFEPVPPGFTPFRQS
What is the function of this protein?
[Val1,Hyp2,Thr6]-bradykinin-Gln,Ser: Induces contraction of rat ileum smooth muscle (EC(50)=710 nM) but has no activity towards smooth muscle from tail artery, urinary bladder or uterus up to concentrations of 100 uM.  Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2); the effect via BDKRB1 is stronger (PubMed:24394432).  Induces contraction of guinea pig ileum smooth muscle (PubMed:16797783).
What are the official names of this protein?
[Val1,Thr6]-bradykinyl-Gln,Ser, Bradykinin-related peptide VS-11.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Bradykinin-related peptide subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_RHOBA
Sequence: MIVEPTVATYNTSDFRKGLKVQIDGEPYLITEMNFVKPGKGNAMYKCKMKNLIRGTTLDRTYKGGDSLEAADVETTTVQFLYRQGQDYVFMDGTTFEQYEVPNEVAGDIWKYLKDGTECSMTLYNGAAIIVEPPQHVQLEVTECGPGTKGDTATNVTKPAMVETGAEFNVPGFIKEGNIIKINTLNNEYVERVNN
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSA1_YEAST
Sequence: MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAFTFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLADTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQWTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:2895105, PubMed:7961686, PubMed:10681558, PubMed:15210711, PubMed:19106090).  Protects the cell against the oxidative stress caused by nascent-protein misfolding and aggregation (PubMed:24424024).  Relays hydrogen peroxide as a signal to the transcription factor YAP1 by inducing the formation of intramolecular disulfide bonds in YAP1, which causes its nuclear accumulation and activation (PubMed:15706081, PubMed:19106090).  Can act alternatively as peroxidase and molecular chaperone.  Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch.  The chaperone function of the protein enhances resistance to heat shock (PubMed:15163410).
What are the official names of this protein?
Peroxiredoxin TSA1, Prx, Cytoplasmic thiol peroxidase 1, cTPx 1, Protector protein, PRP, Thiol-specific antioxidant protein 1, Thioredoxin peroxidase type Ia, TPx type Ia, Thioredoxin-dependent peroxide reductase, Thioredoxin-dependent peroxiredoxin TSA1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with ribosomes (PubMed:18271751). Colocalizes with sites of protein aggregation adjacent to active mitochondria (PubMed:24424024).
Protein: FTSH_RHOE4
Sequence: MNRKTVFRNVLLVAVVLLVIYAFSYFSNDTRDFKTVDTSVAISQLDAKNVASAQIDDREQQVRLWLKNGNDATDGKTQILAKYPASASEQIFDKVEGAGADKFNTTVTQESWLTSILLFVLPMIILFGIFFFVMNRMQGGGGRGGVMGFGKSKAKQLTKDMPKTTFADVAGADEAVEELYEIKDFLQNPARYQALGAKIPRGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDMFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRTGIILIAATNRPDILDPALLRPGRFDRQIPVGAPDLAGRRAILRVHSQGKPIDPNADLEGLAKRTVGMSGADLANVINEAALLTARENGTVITEASLEESVDRVVGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIEPVYKVTILARGRTGGHAMTVPEDDKGLMTRSEMIARLVMAMGGRAAEELVFHEPTTGASSDIDMATKIARAMVTEYGMSAKLGAVRYGQEGGDPFLGRSMGVQSDYSHEIAREIDEEVRNLIEAAHTEAWAILNEYRDALDLIATELLERETLTRKDLEKILAGVEKRPRITAFNDFGGRTPSDRPPVKTPRELAIERGETWPEPAAAPVLVKAGAPNSGVPNGGVPNNGGLPNNGNQGPSNGYAQPSYPQPSAPQQTPQPGTPDYGAPAGWSAPGWPPRENPSPTYPGQQSGGYTGGQNPTPPNQSQGQYGQPQHGQPQPDQGQYGQPHPGQQAYPEQPHPGRRYPAQPDYPVQYPDGGPFADPNRGNPSGENQWQSPTPEQPQTPPPHHSAEDDGPSTARWDGPDGSR
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: TUSA_HAEIN
Sequence: MSEISVTQTLDTLGLRCPEPVMLVRKNIRHLNDGEILLIIADDPATTRDIPSFCQFMDHTLLQCEVEKPPFKYWVKRGK
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP10_THEON
Sequence: MRFRIRKCPSCGRYTLKETCPVCGTKTKIAHPPRFSPEDPYGEYRRRLKREQLGIVKR
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: KDGK_SACS2
Sequence: MVDVIALGEPLIQFNSFNPGPLRFVNYFEKHVAGSELNFCIAVVRNHLSCSLIARVGNDEFGKNIIEYSRAQGIDTSHIKVDNESFTGIYFIQRGYPIPMKSELVYYRKGSAGSRLSPEDINENYVRNSRLVHSTGITLAISDNAKEAVIKAFELAKSRSLDTNIRPKLWSSLEKAKETILSILKKYDIEVLITDPDDTKILLDVTDPDEAYRKYKELGVKVLLYKLGSKGAIAYKDNVKAFKDAYKVPVEDPTGAGDAMAGTFVSLYLQGKDIEYSLAHGIAASTLVITVRGDNELTPTLEDAERFLNEFKT
What is the function of this protein?
Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway.  Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3-deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively.
What are the official names of this protein?
2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase, 2-dehydro-3-deoxyglucono/galactono-kinase, 2-keto-3-deoxy-galactonokinase, 2-keto-3-deoxygluconokinase, 3-deoxy-2-oxo-D-gluconate kinase, KDG kinase, KDGal kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: SYS_XANCB
Sequence: MLDPALLRQHPADLAERLRSTRGFDLNTAELESLESERKRIQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGFGDELKASEDALDVIRAQLEGIALGIPNLPAANVPAGKDESENVEQARWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSGARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGDSKRYLIPTSEVPLTNIVRDAIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACSPEDSEAEHQRMTRCAEVVLEKLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQATYREISSCSNCGDFQARRMQARWRNPASGKPELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPDALRPYMGGLERIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_XANC5
Sequence: MDENKKRALSAALSQIEKQFGKGSVMRMGDRVIEAVEVIPTGSLMLDIALGIGGLPKGRVVEIYGPESSGKTTLTLQAIAQCQKNGGTAAFIDAEHALDPIYAAKLGVNVDDLLLSQPDTGEQALEIADMLVRSGSVDIVVVDSVAALTPKAEIEGEMGDQLPGLQARLMSQALRKLTGNIKRSNTLVVFINQLRMKIGVMMPGQSPEVTTGGNALKFYASVRLDIRRIGAIKKGDEIIGNQTKIKVVKNKLAPPFKQVVTEILYGEGISREGELIDMGVEAKLVDKAGAWYSYGDERIGQGKDNARTYLRDNPQVATRLEAELREKFQPAEAPREAGDDEDKE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERA_ALOVR
Sequence: VNQIGSVTESIEAVKAALVSHGAGVAVVGRKINLAGGPSYTVELGRFDGLVSRALYGLSKLPELGTHGLTLICISWALRVMSNVHDFFVHVAAKVESIHQYIESMRYGSLSPTIFDNYSKDCMIAHGAAHFLKXRPPDPAETRGGAVADNGSGAVARMPTLEEYGTNLTKLAEEGKANFDAAMVKLKNFSFILMFGVLGTIISFCLISSGAVLLLKHHVFPDSNINPSSGAAITSGVRGDLRAYVVAYLDPSRTSFTVDNAIYGEIRRTVLAWLIDSGTLQLSEKVLALVLTMVAATVLGVAKSMIKMGQIEVLTGTQGEIRAAEIVVEQLHAESGKPVLVALTGSIDKMTKDNVLNKTCK
What are the official names of this protein?
Peroxidase A.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RN208_HUMAN
Sequence: MPSDPGPEAGSGWPGLLMSCLKGPHVILKMEAMKIVHPEKFPELPAAPCFPPAPRPTPTLAPKRAWPSDTEIIVNQACGGDMPALEGAPHTPPLPRRPRKGSSELGFPRVAPEDEVIVNQYVIRPGPSASAASSAAAGEPLECPTCGHSYNVTQRRPRVLSCLHSVCEQCLQILYESCPKYKFISCPTCRRETVLFTDYGLAALAVNTSILSRLPPEALTAPSGGQWGAEPEGSCYQTFRQYCGAACTCHVRNPLSACSIM
What are the official names of this protein?
RING finger protein 208.
Protein: GLMS_NEIMA
Sequence: MCGIVGAIRAHHNVVDFLTDGLKRLEYRGYDSSGIAVNTDGKIKRVRRVGRVQLMEDAAREKGISGGIGIGHTRWATHGGVTEPNAHPHISGGMIAVVHNGIIENFESERKRLEGLGYRFESQTDTEVIAHSINHEYAQNGGKLFEAVQEAVKRFHGAYAIAVIAQDKPDELVVARMGCPLLVALGDDETFIASDVSAVIAFTRRVAYLEDGDIALLASDGIKRLTDKSGLPAERKVKVSELSLASLELGPYSHFMQKEIHEQPRAIADTAEVFLDGGFIPENFGKNAKSVFESIRSVKILACGTSYYAALTAKYWLESIAKIPSDVEIASEYRYRSVIADPDQLVITISQSGETLDTMEALKYAKSLGHRHSLSICNVMESALPRESSLVLYTRAGAEIGVASTKAFTTQLVALFGLAVTLAKVRGLVSEEDEARYTEELRQLPGSVQHALNLEPQIAAWAQQFAKKTSALFLGRGIHYPIALEGALKLKEITYIHAEAYPAGELKHGPLALVDENMPVVVIAPNDSLLDKVKANMQEVGARGGELFVFADLDSNFNATEGVHVIRAPRHVGELSPVVHTIPVQLLSYHVALARGTDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_CERSK
Sequence: MQEFTKLTGVAAPMPLVNIDTDMIIPKQFLKTIQRSGLGKNLFDEMRYNPDGSEIPEFVLNQPAYRDAQIIVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIVMPPEVVEVLMEDARRGANARMTVDLEAQTVTTSDGQSFPFQVDSFRRHCLMNGLDDIGLTLEKAASIDGFERDLATLRPWV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ARGB_DESVV
Sequence: MDCVENARLQSKVLIESLPYLRQFHGETVVIKYGGHAMKDEALKKAFALNVALLKLVGINPVIVHGGGPQIGKMLEQLNIQSHFREGLRVTDDATMDVVEMVLVGKVNKEIVNQMNLAGAKAVGLSGKDGMLIRARKMEMVISKEAQAPEIIDLGKVGEVMGVNTTLLRSLERDGFVPVIAPVGVDDNGETYNINADAVAGAVAAALKAKRLLLLTDVAGILDHDKKLIRSVNMREAVNLFSDGTLTGGMIPKVKCCLEALEEGVEKAMIIDGRTENCILLELLTDKGVGTEIVSDRAAQAACNCVLR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_BLOFL
Sequence: MRKYFKERDVPFIIFLMGPTASGKTSVVIELKKQKLGIKIISVDSALVYKNMNIGTAKPSVDELEIAPHQLIDIRDPADCYSVSDFYHDAILEINKIIRSGYVPVLVGGTMLYFKTLLTGLYQLPGKSQNIRNDLIYEAQKIGWVNMYNKLKCIDPIVSKTIHCNDHKRIIRALEVFLSSGKTLTELKQKFLNQQSQRYKVLQFALMPSKREFLYNRIEQRFYKMLKSGFEDEVRLLFSRPDLHDGYQSSISCVGYRQMWEYLSGNVEYDQMIYKGIYATRRLVKNQLTWLKKWPNVHWLNGDNVLIAVNDMLSVLSKYSCVI
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TRUA_METPB
Sequence: MPRYKLVIEYDGGPFCGWQRQADDPTVQAAIETAVTRFSGETARLTCAGRTDAGVHAIHQVAHLDLARDWRTDTVRDALNAHLRPQPIAIVSAEVVTHDFDARHSAIRRHYRYRILNRRSPAALTRAHVWHVPWPLDADLMHAAAQRLLGRHDFSAFRAAECQAASPVRTLEQLDVTRQRMGLFEEIVIATSARSFLHHQVRAMAGTLMLAGCRRLSADDVAEILATKAKHRCGPLAPACGLTFVGVDYDEK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RNZ_PICTO
Sequence: MASTFKITFLGTGGSVPKPGRGLPAIAVQVDNIVNLFDCGEGTQKQFMKSGVSFMNVKNIFISHFHGDHFFGLPGLLSTFSFNGRIDDLNIFGPPGTIDEIKKVLSLIDFKITYNIKIAEMEENKKYDFDLFDVYAIKNDHTKYGYSYKLKEKDLIKINREKADSIGFPKNKLELLRNNGEYYYMGKRYSIWDVADGIKPGRSIVYSGDTRPFNDMLKFASNCDVLIHDSTMDASIENLANEYGHSTARQAAEIALKANVKRLFLFHYSSRYNDLNLLLNEAKSIFNDSYLSREMLEFNVDKKTELIKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: QUEF_PSEPF
Sequence: MHPAAEHSPLGKSSEYIATYTPSLLFPIPRTAKWAELGLTAETLPYKGVDFWNCFELSWLLPSGKPVVAIGEFSIPADSPNIIESKSFKLYLNSLNQTPFADTASLEATLVKDLSAAAGKPVGVRVRSLKDVEAEGVVALPGVCIDDLDISVSDYEHPRPELLRCDDSRVVEESVHSHLLKSNCPVTSQPDWGSVVVEYRGAALDHASLLEYIVSFRQHSDFHEQCVERIFLDLQRLLKPEKLTVFARYVRRGGLDINPYRSTESVQLPNHRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_ROSS1
Sequence: MRDRVYRTEAIIIRRSDAGEADRLVTILTPLGRQRVVARGARKLHSRLAGHIELFTHTMLMLAIGRNLHIVTQSSPLDRFERLRTDLERIGAAYYAAELVDRLVEEEAENKRAFSILLGTLRALNAGAAIDLTLRAYELHLLDALGYRPQLYECAACGAVLTEATNRFSPVTGGALCPDCAGVDRLALPMSLAAFKLLRYLQSQPLEISGELRISPATRAETESLLRAYLRHILERDPRSLAFLDDVRQMLRTSSPASVGSSATRYFAQGDTDENDRDPPGAR
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: NUOB_LEGPC
Sequence: MAVAELEKKVFELTTVEKLVGWARSGSMWPMTFGLACCAVEMMHVGAARYDLDRFGIIFRPSPRQSDVMIVAGTLCNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGIIQLQNKIRRKPVLEA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DHE4_BOTFU
Sequence: MSNLPSEPEFEQAYNELASTLENSTLFEKNPEYRTALKVVSIPERVIQFRVVWEDDKNQVQVNRGYRVQFNSALGPYKGGLRFHPTVNLSVLKFLGFEQIFKNALTGLNIGGGKGGADFDPKGKSDNEIRRFCVSFMRELSKHIGADTDVPAGDINVGGREIGFLFGAYKAIQNKWEGVLTGKGGSWGGSLIRPEATGYGLVYYVAHMIQYAGQGSFQGKRVAISGSGNVAQYAALKCIELGATVVSLSDSQGSLIAEGDAYFTPEDVGKIAELKLKRQSLTAFEHGGKYKYIEGSRPWTHVKVDVALPCATQNEVSKEEAESLVASGARYIAEGSNMGCTQEAIDVFEAERKEKKDKAIWYAPGKAANAGGVAVSGLEMAQNSARISWTQEEVDEKLKDIMKNAFETGLETPKKYVEAKDGEYPSLVAGSNIAGFVKVASAMHNHGDWW
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH, NADP-dependent glutamate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: AACUC_ASPA1
Sequence: MVSNEYLTHGDKDEFDPAKWSSTPGELPPRSPATNLNVLIVGAGPAGLITALECWRKGHNVVRILERSQGPVYTGDIIVIGPSAICTLRHWPEICRELDQDRSDSVMYYRRHNGELILGPTTLGYNSPEHLAQRHGLPYVAPHQVRRQFYRMLLRQVARIGLQVEYGQRVERYFEDEAAGVGGVVTADGSVRAAHLVVAADAFKTRSDLLIAGRHAPTRSSGMSVYRAALPTELALRDPAFQARWGEVVARGESHHEFWIGPGMHLGLFISPNFVAYGLSPRDKFLQPGGIEPIESWDPDVNPQEVLDVLHRIPDWDPAIEGLIRHTPPRATVHWPLLWRNLRREWTSKAGRVVQVGDAAHTTVPASISGGTLAIEDAVTLAACLQLACAGGAPGGAPLGARIYNLLRYQRVSCVQKMSFVNSENLGAADMNEVLKKDPEKVKVRFPKWLFQHDPEAYVYEKYGQAYAHLVLGTDFQNTNFPPGHDFKMWTIEEIHADILAGKKVADLLDGDWD
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer secalonic acid D (PubMed:30996871, PubMed:33891392).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase AacuL (Probable).  The atrochrysone carboxyl ACP thioesterase AacuM then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase AacuI, and oxidized by the anthrone oxygenase AacuG to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by a yet unidentified oxidoreductase (Probable).  A-ring reduction by the short chain dehydrogenase AacuN, dehydration by the scytalone dehydratase-like protein AacuK and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:33891392).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) AacuH then yields monodictyphenone (PubMed:33891392).  Monodictyphenone is transformed into compounds with the tetrahydroxanthone skeleton via methylesterification by the methyltransferase AacuQ, followed by the action of the flavin-dependent monooxygenase AacuC, the isomerase AacuP, and the short chain dehydrogenase/reductase AacuF or AacuD (PubMed:33891392).  AacuF and AacuD should accept the same compound as a substrate but perform the ketoreduction with a different stereoselectivity, thus yielding blennolides B and A, respectively (PubMed:33891392).  In the final step of the biosynthesis, the cytochrome P450 monooxygenase AacuE accepts blennolide B and/or blennolide A to conduct the dimerization reaction to furnish the tetrahydroxanthone dimers, secalonic acids D, B, and F (PubMed:33891392).
What are the official names of this protein?
FAD-dependent monooxygenase AacuC, FMO AacuC, Secalonic acid biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.