PharMolix/UniProtQA huggingface dataset:
Protein: NUD12_HUMAN
Sequence: MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPEIVQFLLEKGCDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRLCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDARWFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550).  The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919).  Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919).  Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796).  May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796).  Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity).
What are the official names of this protein?
NAD-capped RNA hydrolase NUDT12, DeNADding enzyme NUDT12, NADH pyrophosphatase NUDT12, Nucleoside diphosphate-linked moiety X motif 12, Nudix motif 12.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome. Cytoplasmic granule. Note=Localizes to cytoplasmic granules in the presence of BLMH.
Protein: NAGZ_SALPB
Sequence: MGPVMLNVEGCELDAEEREILAHPLVGGLILFTRNYHDPEQLRELVRQIRAASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFFALHGLEEGGRLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPAKALAMATRFIDGMHDAGMKTTGKHFPGHGAVTADSHKETPCDPRPETDIRGKDMSVFRTLISENKLDAIMPAHVIYRAIDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERAQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRRELMDSARWKTASAQLNQLHERWQEEKAGH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_YERPA
Sequence: MQSFLPFSRPAIGSEEINAVANVLGSGWITTGPQNHQLETDFCQIFGCKHAIAVCSATAGMHITLLALGIGPGDEVITPSQTWVSTINMIVLLGAEPVMVDVDRDTLMVNAAAIEAAITPNTKAIIPVHYAGAPCDLDALRQISQRHGIPLIEDAAHAVGTRYRDQWIGEQGTAIFSFHAIKNITCAEGGLVATDDDELAARVRRLKFHGLGVDAFDRQIQGRSPQAEVVEPGYKYNLSDIHAAIAVVQLRRLPEINARRQALVASYHKALAHLPLQPLALPHYSHQHAWHLFMVRVDEERCGISRDQLMACLKDMGIGSGLHFRAVHSQKYYRERYPHLCLPNTEWNSARLCTLPLFPDMLDSDIERVANALTTIIGSHRVTK
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: BIOW_METM6
Sequence: MFSLKMRASRNGNHVSGAERLVNEEKIEKISSELIKRAMSHENGVPDFINLKIEKVTEKINKLKHLEIKTVHSTSKENSRNIARNLLKNELEKYYLKNGKDIEKIDELIDFAFKIIDAGNMRGAAILDLDGNRLENILERGIRVKNIDTTEELSEKILKDSSLTKRTVDAIAIATKVVNCGVISELCTSDNFSYTTGYVATNDGYFRILNLKDKGQVGGRVFFVENSKIDELYDKLENMPVIVY
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: UREE_KLEP3
Sequence: MLYLTQRLETPAAATASVTLPIDVRVKSRVKVTLNDGREAGLLLPRGLLLRGGDVLSNEEGTEFVQVIAADEGVSVVRCDDPFMLAKACYHLGNRHVPLQIMPGELRYHHDHVLDDMLRQFGLTVTFGQLPFEPEAGAYASESHGHHHAHHAHHAHSH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1147_SYNY3
Sequence: MTKTELLWPALITALATMLYLVLVINVGRARAKYGVMPPATTGNEDFERVLRVQYNTLEQLAFFLPGLWLFAIYRDPTIAAILGAVWLLGRILYAWGYYQAAEKRMVGFALGSLSSMILVVGALLSILWQLRQLSQF
What are the official names of this protein?
Uncharacterized protein sll1147.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMT_STRSV
Sequence: MMKIIFMGTPDFSATVLKGLLDSGQYEVLAVVTQPDRAVGRKREIRMTPVKELALEYKLPVYQPEKLAKSSDLEELMNLEADGIVTAAFGQFLPSCLLDSVDFAVNVHASLLPKYRGGAPIHYALINGDEQAGVTIMEMVKEMDAGDMIASKATPIEETDNVGTLFEKLALIGRDLLLDVLPAYRAGQIIPQPQDPSQVTFSPNISPEEERIDWSKTNRQIFNQIRGMYPWPVAHTLLQGQRFKIYEADMMAGSGQPGQILSISKKELVVAAGKGALSLKTVQPAGKPKMAIVDFLNGLGRSLSLGDTFGK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: DNLJ_STAAW
Sequence: MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEYKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVNNIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: CFD1_EMENI
Sequence: MPLEGIKNIILILSGKGGVGKSSVTLQLALALTLQGKSVGVLDIDLTGPSIPRLVGLEGAKITQSSNGWVPVPVHEAEAQTASGNDAAVALSDDGGDENKDVERAKPRGSLRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLTDVYWGDTDYLLVDTPPGTSDEHIALAEELLKLSTTSPSSTGVGALPRLTGAVLVTTPQAIATSDVRKEVNFCVKTNIPTLGVIENMSGYTCPCCGEVSNLFSSGGGEVMAREMGVRFLGKVPVDVQFGALVEGKSQEESDDEDEDRERNKVEEEKGQDFVDERPLVERYKECWSYGQFEGFAKTLIGEIEG
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The nbp35-cfd1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor cfd1, Cytosolic Fe-S cluster-deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNA_NEMVE
Sequence: MSLEAIKYKKGRLEILNQLLLPHESTYEVVSDTEDGWKAIREMKVRGAPAIAIVGALSLAAEIYSKPFASSEELAEFVKQKLQYLNTARPTAVNMTNAVIELTAFVADLTKCSPKDMKQKLLSKIEGMLSEDIAQNKAIGKFGAESILGAVGGPVRMLTHCNTGSLATAGYGTGLGVIRSIHEMKQLEHVYCTETRPYNQGSRLTAYELVYEKIPSTLIADSAVSMAMKTKKISAVVVGADRIACNGDTANKIGTYQLALAAKHHEIPFYVAAPVTSIDFSLVNGDAIVIEERSPLELTSVKGIPVAASGIGVWNPAFDVTPAGLITGIVTEHGTFSPQEMKDKLLALKG
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZC3HE_XENLA
Sequence: MTAIKGKLQELGAYVDEELPDYIMVMVANKKSQKQMTDDLSLFLGSNTTRFTTWLQGVLDKLRSVTPESNSMKTSDAIIFESSMPSLKSLSNSRDDLAKDVPTLTVSSTRHGRYDSSTSSHVQATGSSGSVARLTSAVKPLREFSPSEAVIDIKLDLDDPFNEDLSLATEIANLSRKRTALSASYRTLRPTAEVYRPPGIGQHAYHTNENNSSLHRFPQSSFVSGRSLKLQSSMTVGSSRIQDVSDLSETYKTAFRLASEKSLREEETSRKRRLPVASSVVKVKKLITDEEEVEEEGEEDEEGTDCIFRTAGISSSVSVPAKPERRPSLPPTKQANKNLILKAISEAQDCISKTTNYSTAAPQKQTVPVIPRSRLLPEEEQLMLLQNRSSLLNYPSHLQELQHQAMPEPLHKLDLLSRLQPNLEEEIELPNPVNSEEAEILRPLDSRSFILKRPKLSKEPSPQIQNNSVSPPCPAQPLPGRMIQPREAPTYEKPASPKFIVTLDGVPSPPGYISDQEVDESMCYTEQGETCVEQLGVVARPEQNYPMQLVTEPLCTNDVVMENTSSGTKEKIRERCKYWPACKNADSCAYHHPTSPCKSFPNCRFADKCFFIHPNCKYDAKCKKADCPFTHASKRFPVPPVKPVSTTSSSHPSSQPCRYFPACKKTDCSFYHPKHCRFNTQCTRPDCKFYHPAVSVPARHTLKWTRAQASD
What is the function of this protein?
May bind to RNA.
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the ZC3H14 family.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Colocalizes with poly(A) RNA in nuclear speckles.
Protein: OMT1_PHACR
Sequence: MPSPLRQLLELMIQAVETLESVCEEKGISLPDLHAPYTPASEAFLRIPAAIEAANVITAAADHMSAIVSPPTSYLYKFLGGPCRAVAIRACLESNVSEIIREAGPSGIHVDDIAKKNGHDAQKLARFLRYLATHHIYREVSPDVFTHSRLSCFFDTYKPSAEVIANPKQKYDNTRGFAAPASHHLDITFKAAALAWETMDDPKTGHSDELTDAPFARAFPEDKTLWNLLERDAFARNRFDLTMVAVAQRQSPDSIFRAFDWERLPAGALVVEVGGGMGTSAFPLATKYPEMRLVVQDLPDVIAKAEKLWTEKMPDALSSGRVVLQGHDCFAPQPQTDAAVFLLKMILHDWSDEYCVKILRQLRAAARPDTALVIVDCLVPLACRLDDAAEAALPGAVGPQAPPPLLPNYGTVNEYVYNMDVMMHLLFNAQERTVAQFTRVLLRAGWRVCAVHRTQEGNGVFLQSVEAVPA
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that preferentially catalyzes the methylation of 4-OH phenolic compounds like coniferyl alcohol, vanillyl alcohol and ferrulic acid.  May play a role in promoting lignin degradation by methylating and inactivating free-hydroxyl phenolic compounds, products of lignin cleavage which are known inhibitors of lignin peroxidases.
What are the official names of this protein?
4-O-methyltransferase 1, Mtrase 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: PHI_METAM
Sequence: MNKYQELVVSKLTNVINNTAEGYDDKILSLVDAAGRTFIGGAGRSLLVSRFFAMRLVHAGYQVSMVGEVVTPSIQAGDLFIVISGSGSTETLMPLVKKAKSQGAKIIVISMKAQSPMAELADLVVPVGGNDANAFDKTHGMPMGTIFELSTLWFLEATIAKLVDQKGLTEEGMRAIHANLE
What is the function of this protein?
Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate.
What are the official names of this protein?
3-hexulose-6-phosphate isomerase, 6-phospho-3-hexuloisomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the SIS family. PHI subfamily.
Protein: ACKA1_VIBVY
Sequence: MSKLVLVLNCGSSSLKFAVVDAENGAEHLSGLAECLHLPEARIKWKLDGKHEAQLGNGAAHEEALAFMVETILASKPELSENLAAIGHRVVHGGEQFTQSALITDEVLKGIEDCATLAPLHNPAHIIGIKAAQKSFPALKNVAVFDTAFHQTMPEEAYLYALPYNLYKEHGIRRYGMHGTSHLFITREVASLLNKPVEEVNIINCHLGNGASVCAVKNGQSVDTSMGLTPLEGLVMGTRCGDIDPAIIFHLHDTLGYSVEKINTMLTKESGLAGLTEVTSDCRFVEDNYGQKEEATRAMDVFCHRLAKYVAGYTATLEGRLDAITFTGGIGENSAPIREMVLNRLGIFGIEVDSEANLKARFGGEGVITTANSRIPAMVISTNEELVIAEDTARLAGL
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase 1, Acetokinase 1.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB9G_ARATH
Sequence: MDNQEVSMDVETPIAKTNDDRSLPFSIFKKANNPVTLKFENLVYTVKLKDSQGCFGKNDKTEERTILKGLTGIVKPGEILAMLGPSGSGKTSLLTALGGRVGEGKGKLTGNISYNNKPLSKAVKRTTGFVTQDDALYPNLTVTETLVFTALLRLPNSFKKQEKIKQAKAVMTELGLDRCKDTIIGGPFLRGVSGGERKRVSIGQEILINPSLLFLDEPTSGLDSTTAQRIVSILWELARGGRTVVTTIHQPSSRLFYMFDKLLLLSEGNPVYFGLGSNAMDYFASVGYSPLVERINPSDFLLDIANGVGSDESQRPEAMKAALVAFYKTNLLDSVINEVKGQDDLCNKPRESSRVATNTYGDWPTTWWQQFCVLLKRGLKQRRHDSFSGMKVAQIFIVSFLCGLLWWQTKISRLQDQIGLLFFISSFWAFFPLFQQIFTFPQERAMLQKERSSGMYRLSPYFLSRVVGDLPMELILPTCFLVITYWMAGLNHNLANFFVTLLVLLVHVLVSGGLGLALGALVMDQKSATTLGSVIMLTFLLAGGYYVQHVPVFISWIKYVSIGYYTYKLLILGQYTANELYPCGDNGKLRCHVGDFEGIKHIGFNSGLVSALALTAMLVVYRVIAYIALTRIGKTKSG
What is the function of this protein?
Together with ABCG31, involved in pollen coat deposition of steryl glycosides required for pollen fitness (PubMed:24474628).  Together with ABCG11 and ABCG14, required for vascular development by regulating lipid/sterol homeostasis (PubMed:24112720).
What are the official names of this protein?
ABC transporter G family member 9, ABC transporter ABCG.9, AtABCG9, Probable white-brown complex homolog protein 9, AtWBC9.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPA_SALG2
Sequence: MVKLAFPRELRLLTPAHFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: VE7_PCPV1
Sequence: MHGKYTTLKDIVLDLSPDPVGLHCNEQLDSSEEDEVDEQATQATQATFTQHYQIVTCCGQCDSNVRLVVDCTGSDIQHLHKLLLGSLNIVCPLCAPQT
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: NRAM_I02A7
Sequence: VIGIVSLMLQIGNIISIWVSHSIQTGNQHQAEPCIQSIITYENNTWVNQTYVNISNTNFLTEKTVASVTLAGNSSLCPISGWAVYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTNWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKVVKSVELNAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDGTGSCGPVSSNGAYGIKGFSYKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTGTDSNFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: RL27_BACTN
Sequence: MAHKKGVGSSKNGRESHSKRLGVKIFGGEACKAGNIIIRQRGTEFHPGENIGMGKDHTLFALVDGTVKFKVGREDRRYVSIIPAEATEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: TOX4_XENTR
Sequence: MEFPGSSDNYLTITGPGHPFLTGTETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLGDPSGVQDEGFATQYGVQTLDMPVEMTHEVMDQTGGLLGAGLAMDLDHPIVTPYSANPPVTIDVSMTDMSSGILGHSQLTTIDQSELSSQLGLSLGGGAILHPVQSPEDHLSPTPSPTSSLHDEDMEDFRRITAPKNIIVEQAKKPKTPKKKKKKDPNEPQKPLSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALALYKANQLSQVAVDTVDLDPPAVPALLSESPVPSPSVVTATSIPECVSSPSAPSPPSQTVALPQQSIAKIIISKQILPAGQNPTSIALSQGVVTVIPATVVTSRGLPLAQLQPSPQAQRVTRSVLQAAMQMPPRLQPPPLQQMQQPPRLQQMAPAQQPSITILQSPPPLQPMQKVRLTLQQPPPLQIKIIPPPLQPQPQAVQVQNQSLSVINVSTSPEAPASPPEQLEVLPEVVQEESPPPQMDVELVSSSPPPSLSPQPRCVRSGCENAPIECKDWDNEYCSNECVVKHCRDTFMAWIAARSQGTLATVK
What are the official names of this protein?
TOX high mobility group box family member 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: POLG_SMSV4
Sequence: NKGKTFTSKYVIMTSNTETPVKPTSRRAGAFYRRVMIVDVTNNAVEKWKSDNPGKAVPKWCFNKDFSHLSLSLRGTEAYCKEYVLDPTGRNHQSRRAPPPQQVTLEQLAQKMVVQHTTNTSEFVTQAGDVPVFGFVCQNNEIDTVYNLLAAVKARYGANFNLYKGMVRTAHENSGCGAHVHVISREDNFRGKVFTVSRSRLESVPHLEGDSFRRSLGVVMSDKDVTTMFYYIKGKVINDQVNLTELPANQHVVTVHTVYDMAWALRRHLKWSGQWQLIKAAFEIMCYPDAAACALRNWMDSTDFSEEHVVTQFIAPGGTIILESCHGARMWATGKRLIRAGGITEAGGPQGGVRFAGLGARNVPWSEILREFMTLISHIWSQIKGATVVLTALTFYLKRFRPRIEAKGKNKNKGARKNTGVALTDDEYDEWRQYRTEKNLDLTVEDFLQLRHRAAMGADDSDAVKFRCWYSERQRNYHDLEDVTIIGRGGVKRELIRKGPLRPRGNDYYDEPDDWYSEGVIDGVAHKNAIVSVDDVDGMHKGYAIHIGHGVYISLKHVVSGNARILSEEPKNLTFTGELATFRLNNILPTAVPVGTSKPIKDPWGNPVSTDWQFKNYNTTSGNIYGACGSSCSLTRQGDCGLPYVDDHGVVVGLHAGSGGDKCPSRKLIVPYAKVDMRVRDTCTKQCYKDNSPTISYKGLLVKETGEPRTIMKGTRLHVSPAHTDDYEECTHQPASLGAGDPRCPISLTGIMVNNLQPYTEASPGPDTATLNRVSKMLTSHMEGYVQKSQTEEGYGSAFYMLNHDTSCGPYIGGRKKDHVKDGVLDKNLLDLLSSKWNRAKLGLALPHEYALGLKDELRPKDKVAVGKRRLIWGCDVGVSTVCRAAFKRVSESIMANHALGFIQVGINMDGPAVEDLFKRLERPKHDRYCVDYSKWDSTQPPKVTSQSIDILRHFTDKSPIVDSACATLKSNPIGIFNGVAFKVAGGLPSGMPLTSIINSLNHCLMVGSAVVKALEDSGVQVSWNIFDSMDLFTYGDDGVYIVPPLISSVMPNVFANLKQFGLKPTRTDKSDAEITPIPADEPVEFLKRTIVRTENGIRALLDRSSIIRQFYYIKAENTENWTIPPKKIDTPSRGQQLYNACLYASQHGEEFYTNKIIPLVQRAIEFEGLHIEVPEFHHAVAAYNGYFNGTEGQPNQIAFASGGLGLSSEVFEN
What is the function of this protein?
Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.  Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis.  This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap.  May cleave host polyadenylate-binding protein thereby inhibiting cellular translation.  It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals.  Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA.  This sgRNA codes for structural proteins.  Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
What are the official names of this protein?
Genome polyprotein.
Protein: RHON1_ARATH
Sequence: MAMSGTFHLTSDYVPGYTLSDSRCFFNSAVSRRTLAILPCSSCLDHKNGRLKSVPNRSSFVCRASSGGYRRNPDFSRLNKHGYRGNNRQSGGREDFDIENSDMLSSRNGPLFNLSSSPKFQATSSPGPREKEIVELFRKVQAQLRARAAAKKEEKKIEEASKGQGKESETVDSLLKLLRKHSGEQSKRQVSKFSSQGEVQGDTVDKQDRTGNLVTSGNKDNNASSFTRPTSSFRRKSPVPRSQSPPAYSSEATFDQSSSYSVTWTQKKDTVELHDEPEHEPAYEHEHEPENESEPGPVTTMLEPDSELKPESSSFYQEEEDDDVTFDVLSQDDGILDVLSDDDESLDDADEDSDEAEEEAVKDLSELKLVELRGIAKSRGLKGLSKMKKAELVELLGSDSS
What is the function of this protein?
Binds to and supports processing of specific plastid RNAs.  Associates via its C-terminal Rho-N domain to single stranded regions of 16S and 23S rRNAs or to rbcL mRNAs.  May be involved in targeting transcripts to RNases such as RNE or RNase J.
What are the official names of this protein?
Rho-N domain-containing protein 1, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: APRF1_ARATH
Sequence: MSLTELDDGLVRRMAMGAVFSDFGGKIHSVGFHRTDDLLVTSSEDDSLRLFDIANAKQLKITYHKKHGTDRVCFTHHPSSLICSSRYNLESTGESLRYLSMYDNRILRYFKGHKDRVVSLCMSPINDSFMSGSLDRSVRLWDLRVNACQGILHLRGRPAVAYDQQGLVFAIAMEGGAVKLFDSRCYDKGPFDTFLVGGDTAEVNDIKFSNDGKSMLLTTTNNNIYVLDAYRGEKKCGFSLEPSQGTPIEATFTPDGKYVLSGSGDGTLHAWNIENPSEVARWENNIGVVSCLKWAPRRAMFVAASTVLTFWIPNDGESPAPADPPTDQQQ
What is the function of this protein?
Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus (By similarity).  Promotes flowering under long days (LD) via the regulation of bolting (PubMed:27968983).
What are the official names of this protein?
Protein ANTHESIS POMOTING FACTOR 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SWD2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL14_GEOSE
Sequence: MIQQESRLKVADNSGAREVLVIKVLGGSGRRYANIGDVVVATVKDATPGGVVKKGQVVKAVVVRTKRGVRRPDGSYIRFDENACVIIRDDKSPRGTRIFGPVARELRDKDFMKIISLAPEVI
What is the function of this protein?
Forms part of two intersubunit bridges in the 70S ribosome (By similarity).  Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.