PharMolix/UniProtQA huggingface dataset:
Protein: KCNC3_HUMAN
Sequence: MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGSIRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP
What is the function of this protein?
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons.  The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient.  The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).  It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells.  Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity).  Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).  Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).
What are the official names of this protein?
Potassium voltage-gated channel subfamily C member 3, KSHIIID, Voltage-gated potassium channel subunit Kv3.3.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484).
Protein: MCM4_ARATH
Sequence: MASDSSLGNTNDGPPSPGENVSSPIENTYSSPAALHRRRRGRSSTPTQFATPPPPPSRLASSNSTPPTSRPSAARSKGRNGHGGGGGGGGGGDPGTPMSTDEPLPSSDDGEEDGGDDTTPTFVWGTNISVQDVKSAIEMFVKHFREARENSDDLFREGKYMVSIRKVIEIEGEWIDVDAFDVFDYDPDLYNKMVRYPLEVLAIFDIVLMDIVSTINRLFEKHVQVRIFNLRTSTSMRNLNPSDIEKMISLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKISEPPTCLKQECMTKNSMTLVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMTVRVGPAHRTVKSVFKTYIDCLHIKKASKLRMSAEDPMDVDNSLRRVDEDVELDEEKLRKFQELSKQPDIYERLSRSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSKSQLLQYIHKLSPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSDSARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLLSRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQEEAIDITTLTTYVSYARKNIHPKLSDEAAEELTRGYVELRKAGKFAGSSKKVITATPRQIESLIRLSEALARMRFSEWVEKHDVDEAFRLLRVAMQQSATDHATGTIDMDLINTGVSASERMRRDTFASSIRDIALEKMQIGGSSMRLSELLEELKKHGGNINTEIHLHDVRKAVATLASEGFLVAEGDRIKRV
What is the function of this protein?
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
What are the official names of this protein?
DNA replication licensing factor MCM4, Minichromosome maintenance protein 4, AtMCM4.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH_VIBPA
Sequence: MKVAVIGAAGGIGQALALLLKNRLPAGSDLALYDIAPVTPGVAADLSHIPTPVSIKGYAGEDPTPALEGADVVLISAGVARKPGMDRADLFNVNAGIVKSLAEKIAVVCPKACVGIITNPVNTTVPIAAEVLKKAGVYDKRRLFGITTLDVIRSETFVAELKGKDPSDIRVPVIGGHSGVTILPLLSQVEGVEFTAEEVEALTKRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLALVRALQGEEGVVECAYVEGDSEHAPYFAQPVKLGKEGVEEVLSYGELSDFEKAALDGMLETLNGDINIGVEFAK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: RS3_SHESR
Sequence: MGQKVHPNGIRLGITKPWISTWYADKSDYANNLNSDWEVRKYLADKLQAASVSKIVIERPAKSIRVTIHTARPGVVIGKKGEDVEVLRAAVSKLAGTPAQINIAEIRKPELDAKLVADSIAQQLERRVMFRRAMKRAVQNAMRIGAQGIKVEVSGRLGGAEIARSEWYREGRVPLHTLRADIDYSTSESHTQYGVIGIKVWIFKGEVLDGMLPQIEEPKQQQPKRKPRGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MUTS_CHLT2
Sequence: MTHKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFFDDALILAQNLDITLTQRQNVPMSGIPATCLDGYVDRLVSRGFKVAIAEQADNTEGSKGLVPRTINRLITPGALLSSSLLPEKANNYVLAINQVGSLYGLSCLDLSIGTFLVAEYDNTKDLIEAICRLAPTELLSHAKFYQKNAAVIKQLQQHLRITLSEYVSWAFEYQSATKKLYTCFQVSSLDGFGLQGLVPAINAAGALLSYIQDKLLLPISHLSIPKIYGQQKHLLIDKASQTNLELLSPIHGEHGKGSLLQVMERTSTPMGGRLLRNTLINPFYDLKEITLRQDSVEFFLQQEDLRKILKRQLSCVRDLERLATKISTSLATPKDIGTLRDSLLSCTHIADNLQNCALPEFLENKFLIAPPLCSLIKTLSTELIQELPLKVSEGNIFANHYHPDLLRLRNIKENSKSWILEYQERIRNETGIKKLKVCYAQALGYYIEVASNLAPQLPKEFIRRQSRLHAERFTTQELQQFQDEVFSVEDKLQTLETKLFKELCFYIVEHRDLILKLSTAVADLDYVVSLAELAAEYDYRRPLVDHSDALSITKGMHPVALTLLDKGTFIPNDTVMHSAQTRMILLTGPNMAGKSTYIRQIALLVIMAQMGSFIPARSAHIGIVDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSLVILDEIGRGTSTYDGLAIAQAVVEFLLFTDGKKAKTLFATHYKELTELEMHCQHVENFHAMVKENSGQPIFMYEIVKGHSKKSFGIHVAKLAGFPLSVVSRAQQILHQFEGPDLRPEPEKAQQLVMF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PRP38_DROME
Sequence: MANRTVKEAKNVHGTNPQYLIEKIIRSRIYDSKYWKEQCFALTAELLVDKAMELRFVGGVYGGNIKPTQFLCLTLKMLQIQPEKDIVVEFIKNEEFKYVRALGAFYLRLTGAALDCYKYLEPLYIDNRKLRRQNRAGQFEIVYMDEYIDELLRNDRVCDIILPRIQKRSILEENNEIEPKVSVLDEDLDDELPSDEEKADETNRPKENSTAVRRPRRVRSKSRSRSRERERRSGQGNSARSRDYYDELEDYDRQRNRVRNRDTHNEDYDRRQNNGRHDRERERQDRDSIRERERDGDRDRRDRERERERDRGRHDQRERDSRGERDRRRY
What is the function of this protein?
Required for pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor 38.
What is the protein family that this protein belongs to?
Belongs to the PRP38 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NECP1_PONAB
Sequence: MAAELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKTAYIKLEDKVSGELFAQAPVEQYPGIAVETVTDSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQESEISKESQEMDARPKLDLGFKEGQTIKLSIGNITNKEGGASKPRTARGGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGGSDADILLDLDSPAPVTTPAPTPVSASNDLWGDFSTASSSVPNQAPQPSNWVQF
What is the function of this protein?
Involved in endocytosis.
What are the official names of this protein?
Adaptin ear-binding coat-associated protein 1, NECAP endocytosis-associated protein 1, NECAP-1.
What is the protein family that this protein belongs to?
Belongs to the NECAP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane.
Protein: KHSE_SOLUE
Sequence: MSASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASPDNLIWQTALTVARNQRMTMPPIELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKPLRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVRLPLPKSFDLAIVVPDFDLPTAKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHEILRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFELTRA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECS_RANJA
Sequence: QNWAKFQEKHIPNTSNINCNTIMDKSIYIVGGQCKERNTFIISSATTVKAICSGASTNRNVLSTTRFQLNTCIRSATAPRPCPYNSRTETNVICVKCENRLPVHFAGIGRC
What is the function of this protein?
The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo.  This lectin preferentially agglutinate a large variety of tumor cells, but it does not agglutinate non-transformed cells and erythrocytes.
What are the official names of this protein?
Sialic acid-binding lectin.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2205_ARCFU
Sequence: MRKRYAALAIVLALILSLALPELLFQLYPSSAVLNVDKLLNPPPENPNPFAAEPPANKYLDSVWAESHRNSYCQASSPFEAPRFPEKLRFEYLTLRDLPITIAFSEPYEDGKRVAWVSTVGFTGKIAKIDLENFSLIDEITPEGHRMGISGAYSVLANRTFFVPKLNRIYAYGDNGRLSRIELKGVFELPEVCSGEEIVGITLTYDGMIAFATNFGRVGVVSPNFGDYALYPINQNCEIAETISNSIAADESGGIYVVTDKAVYRINWDGKSLRLGWRAEYQTGEQRGGRLGKGSGSTPSLMNCGEDRFVVITDGQRLMHMVLFWRDEIPEDWKGIEGRDRRIAAEVPVTFGFEKDESYSEQSVLVRNCSAAITNNRLGLRLLDLLPERLQPFSMLLSNVPGIAPYGVEKFEWDAEKRALRSVWASNVSIPNAIPTMSDKTNLLYAIGQRGGFWTLEAVNWESGEAVWYARISPLPAHNSFYAATEIGPDGCIYTGMLWGVARLCNAD
What are the official names of this protein?
Uncharacterized protein AF_2205.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AVLB2_WHEAT
Sequence: MKVFILALLALTATTAIAQLETTCSQGFGQSQQQQQPGQRQLLEQMKPCVAFLQQKCSPLRMPFLQTQVEQLSSCQIVQYQCCQQLAQIPERTRCHAIHIVVEAIIQQQSQQQWQEPQQQAQHKSMRMLLENLSLMCNIYVPVQCQQQQQMGQQPQQQQLQEQLTPCATFLQHQCSPVTVPFPQIPVDQPTSCQNVQHQCCRQLSQIPEQFRCQAIHNVAEAIRQQQPQQQWQGMYQPQQPAQHESIRMSLQALRSMCNIYIPVQCPAPTAYNIPMVATCTSGAC
What is the function of this protein?
Seed storage protein.  Might be integrated via inter-chain disulfide bonds within the glutenin polymer (By similarity).
What are the official names of this protein?
Avenin-like b2.
What is the protein family that this protein belongs to?
Belongs to the prolamin family.
Protein: YKT6A_XENLA
Sequence: MKLYSLSVLYKGENKVHLLKSAYDVSSFSFFQRSSIQEFMAFTSQLIVERSDKGSRSSVKEQEYLCHVYVRNDSLAGVVIADNEYPPRVCFTLLEKVLEEFSTQVDRIDWPSGSPATIQYNALDSYLSKYQNPRDADPMSKVQAELDETKIILHNTMESLLQRGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCDIM
What is the function of this protein?
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment.  Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5.  Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5.  Has a S-palmitoyl transferase activity.
What are the official names of this protein?
Synaptobrevin homolog YKT6-A, Xsnare1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
Protein: SYC_SHEFN
Sequence: MLKIYNSISRDKQEFKPINPGKIGMYVCGVTIYDLCHIGHGRTFVSFDMIVRYLRYIGYEVNFQRNITDVDDKIIKRAAENNESCESLTERLIAEMHQDFDALNMKRPDFEPRATLHIEEIIDMVQRLLDRDHAYVASNGDVLFSVASFPEYGQLSGQNLDQLQAGARVEIDNAKRNPMDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSKHLGLHFDIHGGGSDLQFPHHENEIAQSCCAHDTPYVNYWMHTGMVMVDREKMSKSLDNFFTIRDVLKHYDAETVRYFLLSGHYRSQLNYSEDNLKQARAALERLYTALKGLDLTVDAAPAEAFVAKFKSAMDDDFNTPEAYSVLFEMVREINRLKTTDMAEASALGVSLKQLADVLGLISQTPEAFFKGEGSDDEVAEIEALIVERNRARTEKDWPAADVARDRLNELGVELEDGGPSGTTWRKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_MYCFA
Sequence: PYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVSSTLLASAKEVETKEQIAATAGISAGDQTIGDLIAEAMDKVGNEGVITVEESNTFGL
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_PECCP
Sequence: MAGNSIGQFFRVTTFGESHGIALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLQQQYGVKVRGYLSQIGDVTCELKDWDQVEQNPFFCPDVDKLEALDELMRALKKEGDSIGAKVSVVAESVPAGLGEPVFDRLDADLAHALMSINAVKGVEIGDGFAVVTKRGSENRDEITPDGFQSNHAGGILGGISSGQHIVAHLALKPTSSIMVPGKTINRQGEATEMVTRGRHDPCVGIRAVPIAEAMMAIVLMDHLLRQRAQCGDVNSQVPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: P3H3_HUMAN
Sequence: MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL
What is the function of this protein?
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils.  Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea.  Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.  Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
What are the official names of this protein?
Prolyl 3-hydroxylase 3, Leprecan-like protein 2, Protein B.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: ERA_COXB2
Sequence: MKPTYCGYAAIIGRPNVGKSTLLNQLLGQKISITSRKPQTTRYQILGVKTFKDIQVIYVDTPGLHASTERTINRYMNRTARGALRDVDAIVFVIEPHWESQDAWVLDNLKEIETPVFLVINKVDKIKNRAELLPLIEKVSSLYAFQKITPLSAKTGDQVGTLEQAVHQLMPESPFYFPPEQVTDRSDQFMASEIIREKLMRLLGQEIPYSLAVTLIEFRKEEKIIRISAVIWVEKKSQKGIVIGKGGERLKRVGTNARLDMEKWFGKRVFLQLWVKVKSGWADNERLLRELGFEE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: SECA_NITSB
Sequence: MIKGVVNKIFGTKNDREIKRYQKRVAKINALEPKYEKLTDEELKKAFNELRQKVKSGQMSMDEALEDSFAITREASKRVLGMRHYDVQLIGGMVLHEGKIAEMKTGEGKTLVATLAVALNAMTDEGVHVVTVNDYLAKRDATEMGKLYEFLGYSTGCITSEIQDDQERKKQYQCDITYGTNNEFGFDYLRDNMKYSLDEIVQRGHNFAIVDEVDSILIDEARTPLIISGPTNRKLDNYVKADQIAKQLEKDKHFTVDEKDRVILLTQEGIAKAEELFGVENLYSLENAILAHHLDQALKANYLFQKDVDYVVRDGEVIIVDEFTGRLSEGRRFSEGLHQALEAKEGVPIQEESQTLADITFQNYFRLYKKLAGMTGTAQTEATEFSEIYGLEVISIPTNRPVIRKDLDDLIFKTEKEKFDAVVKKIKELHQKGQPVLVGTTSIEKNELLHKLLKKEKIPHAVLNAKHHEKEAEIIAQAGRKGAVTVATNMAGRGVDIKIDDEVRELGGLFILGTERHESRRIDNQLRGRAGRQGDPGASQFFLSLEDNLLRIFGGDRIKNIMNRLGIEEGEHIESKMVTRAVEKAQKRVENMHFESRKHILEYDDVANEQRKTIYKFRQELLNPEYDIASKIRENRAEVVEELLSQSEIFPETPKDDFNLEKLSKVIQEELGTKIGVEEMKDKEYDELKNFLIERLEKEYEEKMGQLEEEQRREIERILYLQVLDNAWREHLYQMDILKTGIGLRGYNQKDPLVEYKKESFNLFMELVNRIKKEAIKTLHLIELRNEQEEEEIRRLEEELAKMEAQIAQEAVMQHGEEVKTEPVITKKKPARNEPCPCGSGKKYKHCCGKSGPKKGILAAANG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: BLA2_STEMA
Sequence: MLARRRFLQFSGAAVASSLALPLLARAAGKTAASAPTDAALTAATDFAALEKAVRGRFGVTLLDTASGRRIGHRQDERFPMCSTFKSVLAATVLSQAERQPALLDTRVPVRDADLLSHAPVTRRHAGKDMTVRDLCRATIITSDNTAANLLFGVVGGPPAVTAFLRSIGDAVSRTDRLEPELNSFAKGDPRDTTTPAAMAATLQRVVLGEVLQLASRQQLADWLIDNETGDACLRAGLGKLWRVRDKTGSNGEDARNDIAVLWPVAGGAPWVLTAYLQAGAISYEQRATVLAQVGRIADRLIG
What are the official names of this protein?
Beta-lactamase L2, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: CAPP_MYCPA
Sequence: MVEASEGTLEPIGAVQRTLVGREATEPMRADIRLLGAILGDTVREQNGQQVFELVERARVESFRVRRSEIDRAELARMFAGIDIHQAIPVIRAFSHFALLANVAEDIHRERRRAIHVAAGEPPQDSSLAATYAKLDRAQLDSAMVAEALRGAVVSPVITAHPTETRRRTVFVTQHRITELMRLHAEGHTETDDGRNIELELRRQVLTLWQTALIRLSRLQITDEIEVGLRYYAAAFFKVIPQVNAEVRNALRARWPGADLLDEPIVAPGSWIGGDRDGNPNVTADVVRRATGDAAYTALAHYLAELTACEQELSMSARLVAVTPELAALAEDCAEKARADEPYRRALRVIRGRLTATAAEILDRRPQHELDLGLPPYATPAELRADLDTVDASLRAHGSALLADDRLALLREGVRVFGFHLCGLDMRQNSDVHEEVVAELLAWAGVHPDYRSLPEDERVELLAAELGTRRPLVGDRAELSELADKELGVVRAAAHAIRRYGPAAVPNYVISMCRSVSDVLEAAILLKEAGLIDASGPEPYCPVGISPLLETIEDLHNGAAILHAMLELPLYRALVAARGQSQEVMLGYSDSNKDGGYLASSWAVYRAELALVEVARKIGIRLRLFHGRGGTVGRGGGPSYEAILAQPPGAVNGSLRLTEQGEVIAAKYAEPQVAQRNLESLVAATLESTLLDVEGLGDTAEPAYAVLDEVAVLAQRAYAELVHETPGFVDYFMASTPVSEIGSLNIGSRPTSRKPTESIADLRAIPWVLAWSQSRVMLPGWYGTGSAFEQWIAAGPQSRAERVDILHDLYRRWPFFRSVLSNLAQVLAKSDLGLAAQYAELVDDAALRRRVFGKIADEHRRTIAMHKLITGQDNLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGDDDELVQRGILLTMNGLASALRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: YVDE_LACLA
Sequence: MAIIGILGTPYNTVEQSPFWWNKVSYTRQSFIDVFQDLGHTVIILPVDKTENIKNYLTLVDKIVLTGGADVSPYLYGEEPNAKLGTTDPIRDRFELATIKAALEANKPILGVCRGLQLLNVYFGGRLYQDLSQTSSQIKHLQSPTPQEIPTHHISVEQESALGFLPENYMVNSFHHQVIKDLGQGLTAIAHGNDGLVEAIENKEKHVLAVQWHPECTWETEHFDKKIFEIFANGTI
What are the official names of this protein?
Putative glutamine amidotransferase-like protein YvdE.
Protein: PURR_SHIBS
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: MGRB_ECO45
Sequence: MKKFRWVALVVVVLACLLLWAQVFNMMCDQDVQFFSGICALNQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL27_LEIXX
Sequence: MAHKKGASSTRNGRDSNAQRLGVKRFGGQTVNAGEILVRQRGTHFHPGANVGRGGDDTLFALAAGSVEFGAKGGRKVVNIVAVEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ARP6_EMENI
Sequence: MGSTKPRPSGKNSISHAQSLPGKTFIIDNGAYNMKAGYAPDSQPLDDEEIALSACAAIPNAIVKTRANRTYVGAQIGTNVTDWNEMLFRRPVEKGYTVNWEAQKEIWENSFFDERTVRSKELHIADPEDVTIIFTEAPNALPALQKNADEIIMEEWGFGGYLRCVVGMAKPFALNTGPSLNAWNEIQSLFEDSVLSQPRAVASPAECLLVVDSGYSHTVITPVYRGRPLQRGIRRLDLGGKHLTNYLKELVSMRQYNMVDETYIMNEVKESVCFVSNDFNRDLERTWKGNRKRGQPDPTDGVVVDYVLPDPNGGKRGFMRPHDPLLGSKKRKAVLAGASAEQLNEDVLVLGNERFTVPEILFTPSDIGMKSAGIPDIILQSLSVLPTGLHPAFLANVLVVGGNSLLPGFMERLETELRQIASAECVVRVRRPKDPIRFAWLGGSRLATNKEELKKVAITRQEYQEHGSSWTTRKFSGAL
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Actin-like protein arp6.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Protein: YD278_YEAST
Sequence: MNVSFRSNYHQGTIRCSVTAITSRSHRGDRGSTPRFGVSFLFSRKIHMLIHLPLLFHCDATSHILLISIFFLLLFALPQHTMGINSTSCCVHFSSSYNYNVHKLA
What are the official names of this protein?
Uncharacterized protein YDR278C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.