PharMolix/UniProtQA huggingface dataset:
Protein: RBS_SILLB
Sequence: MASLMSNAAVVTASTAAQANMVAPFSGLKSTSAFPVSRKSNVDITSLATNGGRVNCMQVWPPRNLKKFETLSYLPTLSEESLLKEINYLLIKGWVPCLEFEVGPAHVYRENNKSPGYYDGRYWTMWKLPMFGCTDASQVAAEVVECKNAYPDAHVRIIGFDNKRQVQCISFIAYKPE
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: URED_ACIAC
Sequence: MTWHARLQLDYRREGPRTVAGFLHDGPLRILQSLYPEGGGICHNVLVHPPGGLVGGDTLDIAATVAPGAHGLVTTPGATRFYRSTGAPALQRTQATLAAGARLEWLPLEALCYSACQAENRLTLSLSPGAECIAWDVTALGLPHSGQPFATGRFTQHIEVPGIWLERGTIDAADGLLMDGRLGLAGHRCLASVFFVAGEALPRERREAALDAARAVIDAHALRETAGATSPHPQVVVVRVLAPVVEPAMELLRRAWGAWREHLWGLQPRQPRIWAM
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUB_BRADU
Sequence: MQTALRTSLPETELASRASFAPHARVVREERVVQASGLPLSIRGLRKSFGDNEVLRGIDLHIPAGQFVAIVGKSGCGKSTLLRLIAGLDKIDAGTISLGSDVQPEDIRVMFQEPRLLPWARVLANVEVGLGRDRASKDAHARAEKALTEVGLADKRDQWPSVLSGGQKQRVALGRALVSRPRVLAFDEPLGALDALTRISMQRLLERVWRDQGFTAILVTHDVSEAVALADRVLVIEEGRIAHDVVVNAARPRERGSVELAGLEGSILSHLLSADDRT
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RLMN_LARHH
Sequence: MKTNLLDFTLPALTEHFAAMGEKPFRAKQVMRWMHQMGQNDFDAMTDLAKSLRAKLHDTATVTVPSLMLEQASSDGTRKWLLDVGTGNRVETVFIPEDDRGTLCVSSQVGCALECTFCSTGRQGFNRNLSTAEIIGQLWWANKSMGVTPKNERVISNVVMMGMGEPLANYDNVVAAMRIMLDDHGYGLSRRRVTLSTSGLVPAMDRLREDCPVALAVSLHAPNDRIRDEIVPINKKYPLRELLAACERYLEKAPRDFVTFEYVMLDQINDRPEHARELVALVRDVPCKFNLIPFNPFPNSGYGRASNNAVRAFRDILAEAGYITTVRKTRGEDIDAACGQLAGQVQDKTQRKVRWLDKGGSTEAGV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HINFP_MOUSE
Sequence: MSPPGKVPRKENLGLQCEWGSCSFVCSAMEEFFDHVTQHLQQHMHGSKEEEEEDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNVIPDTPDHFLCLWEHCESVFDNPEWFYRHVDAHSLCCEYQAVSKDNHVVQCGWKGCTCTFKDRCKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQRFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPYKCDCCDYSCKNLIDLRKHLDTHSKESAYRCDFENCNFSARSLSSVKSHHRKVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLQQLQEGSDPGLALNESSLQGIVLETVLGGPGPEEETEEEGRVVEGTALSASQDNPSSAIHMVSQTDTQGQRDIVYCVLSEGPGEPPPVSETLKRDGKARGT
What is the function of this protein?
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter.  Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT.  Also activates transcription of the ATM and PRKDC genes.  Autoregulates its expression by associating with its own promoter.
What are the official names of this protein?
Histone H4 transcription factor, Histone nuclear factor P, HiNF-P, MBD2-interacting zinc finger protein, Methyl-CpG-binding protein 2-interacting zinc finger protein.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with discrete nuclear foci.
Protein: PLA1_PLAAC
Sequence: MKLSFSLCIFFFNLLLLLQAVISADIVQGTCKKVAQRSPNVNYDFCVKSLGADPKSHTADLQGLGVISANLAIQHGSKIQTFIGRILKSKVDPALKKYLNDCVGLYADAKSSVQEAIADFKSKDYASANVKMSAALDDSVTCEDGFKEKKGIVSPVTKENKDYVQLTAISLAITKLLGA
What is the function of this protein?
Invertase inhibitor (Probable).
What are the official names of this protein?
Putative invertase inhibitor, Pollen allergen Pla a 1.
What is the protein family that this protein belongs to?
Belongs to the PMEI family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Endoplasmic reticulum. Note=After 5 min in germination medium, detected as a soluble protein and released from apertural and non-apertural regions of pollen grain wall. In mature, non-hydrated pollen grains, predominantly associated with the endoplasmic reticulum (ER) concentric cisternae, which are situated between the vegetative nucleus and the generative cell. After 5, 15 and 30 min as well as 2 h of hydration, localization to this ER region is noticeably decreased.
Protein: DSCR9_PANTR
Sequence: MGRICPVNSRARRLRARPGRPSGDSLPYHQLQGGAPRLWSPDPGRPAAYRRAHVCDVTAPRWGSTSRQGEGAVLQRMLRRRAPPSWSRDHAYSRRGWENVALFLNRKRKQEGTENTSICCRPESALACGGNLSPQFLKKVIQIQTQELW
What are the official names of this protein?
Down syndrome critical region protein 9.
Protein: ATPB_THEM4
Sequence: MSKRSKGKILRVIGPVVDVQFEEGELPDIYDALEVINPQTGKKLILEVEQLIGDNAVRTVALDTTDGLMRGLEVENTGEPIKVPVGKGALGRMFNVIGEPIDGKEDVKDVEYWPIHRTPPSITEQSTSVEILETGIKVIDLLAPFPKGGKIGFFGGAGVGKTVLVMELIRNIAIEHHGFSMFAGVGERTREGNELYLDMQEAEVLDNTVLVFGQMNEPPGARFRVALSALTMAEYFRDVEGRDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLATDMGELQERITSTKKGSITSVQAIYVPADDITDPAPATTFTHLDATVVLSRRRAALGLYPAVDPLDSTSKMLDPNVVGQEHYEVARGVQEVLQRYKDLQDIIAILGMEELSEEDKLIVQRARKIERFLSQPVHVAEKFSNIPGKYVPISETIRGFKEILEGKYDDLPEMAFYMVGTIDEAVEKAKKLQKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: P5CR_TREPA
Sequence: MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRDRQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGVLALEEQGLRRAVIHAVRAALSSS
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_THEP1
Sequence: MRVLGIETSCDETAVAVLDNGKNVVVNFTVSQIEIHQKFGGVVPEVAARHHLKNLPILLKKAFEKVPPETVDVVAATYGPGLIGALLVGLSAAKGLAISLEKPFVGVNHVEAHVQAVFLANPDLKPPLVVLMVSGGHTQLMKVNEDYSMEVLGETLDDSAGEAFDKVARLLGLGYPGGPVIDRVAKKGDPEKYSFPRPMLDDDSYNFSFAGLKTSVLYFLQREKDYKVEDVAASFQKAVVDILVEKTFRLARNLGIRKIAFVGGVAANSMLREEVRKRAERWNYEVFFPPLELCTDNALMVAKAGYEKAKRGMFSPLNLNADPNLNV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_ENTFA
Sequence: MTEERNQRKVYQGRVVSDKMDKTITVVVETKKNHPIYGKRMKYSKKYKAHDENNTAKVGDIVKIMETRPLSATKRFRLLEVVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CYOA_ECOL6
Sequence: MRLRKYNKSLGWLSLFAGTVLLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKYRASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITIEVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGMQTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATPDRAAFDQWVAKAKQSPNTMSDMAAFEKLAAPSEYNQVEYFSNVKPDLFADVINKFMAHGKSMDMTQPEGEHSAHEGMEGMDMSHAESAH
What is the function of this protein?
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity).
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 2, Cytochrome o ubiquinol oxidase subunit 2, Cytochrome o subunit 2, Oxidase bo(3) subunit 2, Ubiquinol oxidase chain B, Ubiquinol oxidase polypeptide II, Ubiquinol oxidase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUTF_ECO55
Sequence: MNIVDQQTFRDAMSCMGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRGASVWPVFNENRTLCVNTLSAGQEPLSNLFGGKTPMEHRFAAARWQTGVTGCPQLEEALVSFDCRISQVVSVGTHDILFCAIEAIHRHTTPYGLVWFDRSYHALMRPAC
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: IF1A_HALS3
Sequence: MSDDGGGRKNLRMPEDDEVFAEVTDMLGANRVQVRCADGEERTARIPGRMQKRIWIREDDIVLVEPWDWQDDKADVTWRYEKSDADQLREEGHIE
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: VP19_BPPRD
Sequence: MEKQTENTRPECPKAFYFVSIPGDFGQTPFASSLMYGSTALAAVYQVKGAIRVVSEHFDLRFADNGFTPAGVTQAEWLGKLITETFGFRLELFL
What is the function of this protein?
Binds to single-stranded DNA (ssDNA).
What are the official names of this protein?
Protein P19.
Protein: VP7_ROTH3
Sequence: MYGIEYTTVLTFLISVILLNYVLKSLTRIMDFIIYRFLLIIVILSPFLNAQNYGINLPITGSMDTPYTNSTREEVFLTSTLCLYYPTEAATEINDNSWKDTLSQLFCTKGWPTGSIYFKDYTNIASFSVDPQLYCDYNLVLMKYDATLQLDMSELADLLLNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDTNTFEEVATAEKLVITDVVDGVNHKLNVTTNTCTIRNCKKLGPRENVAVIQVGGSDILDITADPTTAPQTERMMRVNWKKWWQVFYTIVDYVNQIVQAMSKRSRSLNSAAFYYRI
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: PAFA_MOUSE
Sequence: MVPLKLQALFCLLCCLPWVHPFHWQDTSSFDFRPSVMFHKLQSVMSAAGSGHSKIPKGNGSYPVGCTDLMFGYGNESVFVRLYYPAQDQGRLDTVWIPNKEYFLGLSIFLGTPSIVGNILHLLYGSLTTPASWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIGLASNGFIVATVEHRDRSASATYFFEDQVAAKVENRSWLYLRKVKQEESESVRKEQVQQRAIECSRALSAILDIEHGDPKENVLGSAFDMKQLKDAIDETKIALMGHSFGGATVLQALSEDQRFRCGVALDPWMYPVNEELYSRTLQPLLFINSAKFQTPKDIAKMKKFYQPDKERKMITIKGSVHQNFDDFTFVTGKIIGNKLTLKGEIDSRVAIDLTNKASMAFLQKHLGLQKDFDQWDPLVEGDDENLIPGSPFDAVTQVPAQQHSPGSQTQN
What is the function of this protein?
Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:18434304).  At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10066756, PubMed:18434304).  Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position.  Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity).  Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:18434304).  Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in lipoprotein particles and uncontrolled pro-inflammatory effects (By similarity).  As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity).  Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity).
What are the official names of this protein?
Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, LDL-associated phospholipase A2, LDL-PLA(2), PAF 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=Associates with HDL particles in plasma.
Protein: RUVA_SYNS3
Sequence: MIGWLRGERIEHWSQGGRQGLVIACAGVGYEVQLASRYLQPLSAGATCTVWIHQVQRDDGSSLFGFPDRRERDLFRVLISVNGIGPQVGLALLESCSAAELIEAIIDGDLRRLTQAQGVGKRTAERLAVELRDRLGAWSAEKNSDHSDLSLVDRSDLKSLPIEPDPLQDLQLTLSTLGYEDLEIRRAMRAVATGEEVPAANDGDGWLRASLRWLNRPSA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: FGR23_CANAL
Sequence: MFASYLLLVLWIIRLVPTTHAHTGNDAEYLLNTVLKRDATSLSRNAYLDSEATSGATNYCSDCDNDEVIVTVDGTSTIWTILLDSTISTLVTTTSTEKTTLTSCGQSCTKSKDASSVSSSSASSSTSRSLIFRTSTKTVTDTTTLPTVTEINTFTTTDSHIVLVYTDINSESTITGDYTFIKNKNTRTVIITDYVTSTVGGETQIVTQTTTSVVYELVVTCPDHDFATTLTGSETFVPPTTAPKPVETPSPEPSTTILSIKSESSVPSATTSVLDTSITLETSSSSIEFSTSTQESSSIGPSSSSSIGSCTSSSISTEESLSTTKLSSSFTSISSWEELSSSFTQSTTSSNAEPSSSFAESFTTESLSSTIEATSSMEDISNNSVLTSSIFSETTTNESSSYTDEPSSSEEITNTYEPSSSTESSTTDQFSSLLSSSLPVTSTSSTTISSATPITTVLSTSITSQDTNCEATITNISTNTLIETITVNGNTTIYTETQLSTYLTSNTSINCPNTNSATTTTTQVIPTATTEQIHTTTLNGSIIVSTETATLKTTVIITHCPECTNESSTSEYSSSLKAESSQQSIPTIESNLSELSVSSTLSLVESTASGKCSGLTTTTFTSIVSTTTESIYTITSNESTFEMTTTVTNIGTIVITTCPTITPVSSSYSSSESLSSSVSTSLLTESNSTISQSTVSTDKSSLTNDNQISTVSTETPLTSITIIETTSKTTESLYTTTSNDSTHIFTTTIIDVQTNTIVTCPTTTSTLTSSHTSDNEKPASLSSSSLIESDHIADGTTTSTTFQSTSTTTVDHHCSSCSEILLSTSSSIIGNKSTSTSISSIETSASSSYHSSEPEVMSSSSSTSIKQSSDSIPSTSQTHVSTTSSSVSSLETTTTTTENSPTSNGFSSSSIVTSVNVPDYVSSSVSSTSSTTSSPSTESSSNGLVSTVTESSTANENTSEITTIDNTSITSEKVTGTNSNPKTSEIIKDATITTSGNVESLHSTTPISSTSIISTNAISSSDTTTLTITNTLTYSIDSITTMKTSSITTAPPPPQQKESSSVLSSSLIINSSTPTIIPTINIPITFEGNANSLGLKNGDNSWIIGIMMIGLLMI
What is the function of this protein?
Putative adhesin which may be involved in cell adhesion and virulence (By similarity).  Involved in the regulation of filamentous growth.
What are the official names of this protein?
Filamentous growth regulator 23, Predicted GPI-anchored protein 40.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: TRXB_DEBHA
Sequence: MVHHNVTIIGSGPAAHTAAIYLSRAEIKPTLYEGMLANGTAAGGQLTTTTDVENFPGFPKGINGTELMDQMREQSVRFGTDIITETISKCDLSSRPFKLWTEWNEDSEPITTDAVVIATGASAKRMHLPGEDTYWQQGISACAVCDGAVPIFRNKPLAVVGGGDSACEEALFLTKYGSKVYLLVRRDQLRASNIMQKRVQNNDKLEILWNSEAKEAKGDGKLLQNISVYNNKTKETKDLPVNGLFYAIGHIPATQIFAKQLETDDQNYILTKPGTAETSIPGVFAAGDVQDKRYRQAITSAGTGCMAALDCEKFLSEEEAK
What are the official names of this protein?
Thioredoxin reductase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGGR_ECOLX
Sequence: MKLKQNIEKEIIKINNIRIHQYTVLYTSNCTIDVYTKEGSNTYLRNELIFLERGINISVRLQKKKSTVNPFIAIRLSSDTLRRLKDALMIIYGISKVDACSCPNWSKGIIVADADDSVLDTFKSIDHNDDSRITSDLIYLISKIENNRKIIESIYISAVSFFSDKVRNTIEKDLSKRWTLAIIADEFNVSEITIRKRLESEYITFNQILMQSRMSKAALLLLDNSYQISQISNMIGFSSTSYFIRLFVKHFGITPKQFLTYFKSQ
What is the function of this protein?
Transcriptional activator of aggregative adherence fimbria I expression in enteroaggregative E. coli.
What are the official names of this protein?
Transcriptional activator AggR, AAF/I regulatory protein.
Protein: MYOC_RABIT
Sequence: MPAVQLLLLAGLVWGAGARTAQLRKANDRSGRCQYTFSVASPSESSCPEQGQTMSAIQDLQRDSSTQRADLESTKARLSSLESLLHRLTLAQTSGPQEIQEELQKELGTLRRERDQLESQTRELEAAYSNLLRDKSALEEEKRRLMQENEDLARRLESSSQEVARLARGQCPQARDTSQDVPAGSREASQWNLDTLAFQELKSELTEVPASRILKENPPVLPRGEEGDNGCGELVWVGQPVTLRTAETITGKYGVWMRDPKPTSPHTQETTWRIDTVGTDIRQVFEYDRISQFVQGYPSKVYVLPRSLESTGAVVYAGSLYFQGAGSRTVIRFELNTETVKAEKEIPGAGYRGQFPYSWGGYTDIDLAVDETGLWVIYSTEEARGAIVLSKLNPENLELEKTWETNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGISKPLAIPFKNRYKYSSMIDYNPLERKLFAWDSFNMVTYDIKLSKI
What is the function of this protein?
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration.  Promotes substrate adhesion, spreading and formation of focal contacts.  Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.  Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways.  Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.  Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling.  Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling.  Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex.  Involved in positive regulation of mitochondrial depolarization.  Plays a role in neurite outgrowth.  May participate in the obstruction of fluid outflow in the trabecular meshwork.
What are the official names of this protein?
Myocilin, Trabecular meshwork-induced glucocorticoid response protein.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. It is only imported to mitochondria in the trabecular meshwork. Localizes to the Golgi apparatus in Schlemm's canal endothelial cells. Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles. Localizes in trabecular meshwork extracellular matrix. SUBCELLULAR LOCATION: [Myocilin, C-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Protein: FABZ_WOLWR
Sequence: MQFNISDIIKILPHSYPFLLVDRVIECDPGKSIKAIKNVTFNEPFFIGHFPGHPIMPGVLIIESLAQASAICVLGKETIENKVVYLRSIENAKFRKPVTPGDTLILQANIQSVCLGVHKFRCIASVSEEKVAEATISAVLQNK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.