PharMolix/UniProtQA huggingface dataset:
Protein: RS14_ACIBC
Sequence: MAKKGMINRELKREKTVAKYAAKRAELKATIANVNASDEERFEAMLKLQALPRNASPVRLRNRCGLTGRPHGYFRKFGLSRNKLRDTVMQGDVPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: CAPSD_SMYEA
Sequence: MGDQPRPPVPPAPGSNPLPMGSTPPVLPGRTPNPNANVANQVGDPFRVLTPEELAAPISAASNKVATREQILGIVADLNALGFVGDPALGLFDLAFHCYDIGSSPSAQPVGPSPFGCSRMQVAAVVRNHCTLRQLCMFYAPSVWNKAVRDNRPPGNWSNLQFTPETKFAAFDFFDGVLNPASQEVPLWRQPTPQEIYASATHKDVATYRAASKAHDRISNSTLLTKGASRSTPPALLPGPDA
What is the function of this protein?
Required for genome encapsidation.  Forms ribonucleoprotein complexes along with TGB1 helicase and viral RNA.
What are the official names of this protein?
Coat protein, Capsid protein, CP.
What is the protein family that this protein belongs to?
Belongs to the potexvirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: TCAB1_MESAU
Sequence: MKTSEERLVVPDSLSSDQAPAPVPQGSPVDENTDSEPVPQPCGGDDRSQVAADSVAGSVVFQEPQQGHPLPLSAPLEVEFNTPGELSPRIEEQELSENVSLPVEDTNQPELASGEDVEGVSEEPGPVDEGDAFWSYNFSQVPRYLSGSWSEFRAHSENFLKGCKWAPDGSCILTNSADNTLRIYNLPPELYSATEQVDYAEMVPVLRMVEGDTIYDYCWYSLMSSSQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQFLVSGNTNGMVSVWDISGAFGDSSKLGPVMTFLPQKDCTNGVSLHPSLPLLATASGQRMFPEPTNSGDEGEPEGDLPLLSLCHAHPEWQLQLWWCGGGPDPSSPNDPQDEKGQGRAEGCGDGLI
What is the function of this protein?
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies.  Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC).  Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes.  In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex.  Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity.  In addition, also controls telomerase holoenzyme complex localization to Cajal body.  During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity.  In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies.  Also plays a role in DNA repair: relocalizes to sites of DNA double-strand breaks in response to DNA damage and promotes the repair of DNA double-strand breaks.  Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ).
What are the official names of this protein?
Telomerase Cajal body protein 1, Guanine nucleotide-binding protein beta 5, WD repeat-containing protein 79, WD40 repeat-containing protein antisense to TP53 gene homolog.
What is the protein family that this protein belongs to?
Belongs to the TCAB1 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body. Chromosome, telomere. Chromosome. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies. In response to DNA damage, localizes to sites of DNA double-strand breaks.
Protein: PUR7_LYSSC
Sequence: MTKGQLLYEGKAKKLYTTEEPNVLLVEYKDSATAFNGEKKEEIEGKGILNNRITSLIFEKLQGNGIASHFVKQLSDTQQLVRKVDIIPIEVVVRNIVAGSLAKRIGLEEGTPLKRPIVEFYYKDDELGDPFITTEHIDVLELATSAEVSAIYDKALAINKVLQPIFADVNVTLIDFKLEFGRDADGHVLLADEISPDTCRLWDATTKQKLDKDVFRRDLGNLTEVYTIILSRLGGK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CH60_CAUVN
Sequence: MAAKDVYFSSDARDKMLRGVNILANAVKVTLGPKGRNVVIEKSFGAPRTTKDGVSVAKEIELADKFENLGAQMIREVASKTNDKAGDGTTTATVLAQAIVQEGLKSVAAGMNPMDLKRGIDKAVAIAIEDIKTSSKKVTTNAEIAQVGTISANGDKEVGEMIAKAMDKVGNEGVITVEEAKTAETELDVVEGMQFDRGYLSPYFITNADKMEVQLEEPLILLFEKKLSSLQPLLPVLEAVVQSGRPLLIIAEDVEGEALATLVVNKLRGGLRVAAVKAPGFGDRRKAMLEDIAILTGAQVVSEDIGIKLENVSLEMLGRAKKVSITKDDTTIVDGVGEKADIEARIAQIKRQIEDTTSDYDKEKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAADEGIVPGGGTALLKASKALAGVVGDNDDQTAGIAIVRRALQAPIRQIAENAGVEGSIVVGKILENDNSAFGFNAQTEQYVDLVVDGVIDPAKVVRTALQNAASVAGLLITTEAAIVEAPKKGGGAPAGGGMPGGMGDMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA1_SALCH
Sequence: MLEARDLYCERDERTLFRGLSFTVDAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGGAGL
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA 1, Heme exporter protein A 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YN28_SCHPO
Sequence: MDNESHSQETESKILEGAKVATRRRRVTRACDMCRRKKIKCDGLRPCKNCKAGKLECTYHMPSSRKSSFSPEYVENLESRVRYLETLLKKNTNFDLSSNSPSFLFFLREQKFQATNELENMSPERKVIFTSMINYGNLFVDAKHGTRYFRGGSSIHVLIQHLIRRLPGDFEICEPYSAYPLGNKNIQFDDNDPEYQFFTPTPRFSIDFMVSSVDPREIQLPGIEEALCITKAAVSYVSGIVFYTTYADFPKKIRLLYSGNYQGNFFPLFLSILCVGYYHHLLNNPSNTELQSLIKKYSFYSERLVKSADNFTIESIQCLLILSIYRYCRTEISAAWYYMKLGLNCCLRLGLHRNITEGFTEEQIDSRRRIFWAIYCYDRQLCTLFGFPLGVRDEDIDQCLPVTPKFPSVTEIEANARLFFFHGVKLYKISSRILTKLYSPNSRNVTKKHISYAVIQDLEQLLDGFYNSLPRVFRAEQPGEFQANHFFYNLQLVYYSFRMLIYRPLLHYLEADSPAMQALKVPDRQTAFTLACKCVDSAIVCVQNLSHLSKGLKRTLDRYYWTTVYCGFSTIVTLIFAALLTKNTNLLIHISVARESIEALAHECVTRRLLPLIDKMRESLMKILESNADGYKQMSPTKAPQVFESESNVPINNGPQQSIDKESNSNTQLPQVETEGQQQSVFDGNIGTIPYQAYNMNEDSFIDINTLSSMLNYHTQAVSIHHPSFYISRSDVPLEEEFQIPNELLAVDPVAESMQENSDIINEAFGLVDPDVSDGKSRESSSLNNSTPFNPTVNIDPASILEHFSQNVMKDSQNS
What are the official names of this protein?
Uncharacterized transcriptional regulatory protein C530.08.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus membrane; Single-pass membrane protein.
Protein: TX16_PHORI
Sequence: EWCGSNADCGDGQCCTGGSFNRHCQSLADDGTPCQKPNDYNEYKFGCPCKEGLICSPINYCQKK
What is the function of this protein?
Non-toxic to mice and insects.
What are the official names of this protein?
U9-ctenitoxin-Pr1a, U9-CNTX-Pr1a, Non-toxic venom protein PRTx16C0.
What is the protein family that this protein belongs to?
Belongs to the u-CNTX family.
What are the subcellular locations of this protein?
Secreted.
Protein: MTNA_GEOUR
Sequence: MSFRTIEWRDNKVVMIDQTRLPGEEVYNEYTDFQSVAEAIRGMIIRGAPAIGVAAAMGIALGAREIIADTHESFFRQLDNVCNVMARTRPTAVNLFWAIERMKRVAESHRDKDLNSIREILKAEAIRIEEEDLEICRAIGRNGAPLIKEGATILTHCNAGGLATAGYGTALGVIRAAHEAGKRIQVFADETRPWLQGARLTSWELMKDGIPVTLISDNMAGYFMRKGEIDVCVVGADRIAANGDTANKIGTYSVAVLAKENKIPFYVAAPVSTLDLSLKSGEDIPIEERHSREVTHLQGLPVAPEGVKVRNPAFDVTPARYIAGIITEKGVVRGDYEKELRALVGR
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: SELO_YERPS
Sequence: MKPRMEYAPEFDNSYARQLSGFYTRLQPTPLKGARLLYHSKPLAQELGLDAHWFTEPKTAVWAGEALLPGMEPLAQVYSGHQFGMWAGQLGDGRGILLGEQRLNDGRYMDWHLKGAGLTPYSRMGDGRAVLRSVIREFLASEALHHLGIPTSRALTIVTSDHPIYREQTERGAMLLRVAESHIRFGHFEHFYYRQQPKQVQQLADYVIARHWPQWVGHQECYRLWFTDVVERTARLMAHWQTVGFAHGVMNTDNMSILGITMDYGPFGFLDDYVPGYICNHSDHQGRYAYDNQPAVALWNLHRLGHALSGLMSADQLQLALEAYEPALMVAYGEQMRAKLGFLERDSQDNDLLTGLLSLMIKEGRDYTRTFRLLSEVEVHSAQSPLRDDFIDRAAFDDWYRRYRSRLQQESIDDDQRQQSMKAANPKYILRNYLAQQAITQAEKDDIQPLQRLHQALQQPFTDQPEFDDLAALPPDWGKHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: WALK_STAAE
Sequence: MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMFGMAKEDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKKTIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE
What is the function of this protein?
Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins.  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR.  In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.
What are the official names of this protein?
Sensor protein kinase WalK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TMM47_MOUSE
Sequence: MASAGSGMEEVRVSVLTPLKLVGLVCIFLALCLDLGAVLSPAWVTADHQYYLSLWESCRKPANLDIWHCESTLGSDWQIATLALLLGGAAIILIAFLVGLISICVGSRRRFYRPVAVMLFAAVVLQVCSLVLYPIKFIETVSLKIYHEFNWGYGLAWGATIFSFGGAILYCLNPKNYEDYY
What is the function of this protein?
Regulates cell junction organization in epithelial cells.  May play a role in the transition from adherens junction to tight junction assembly.  May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309).  During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (PubMed:21881001).
What are the official names of this protein?
Transmembrane protein 47, Transmembrane 4 superfamily member 10.
What is the protein family that this protein belongs to?
Belongs to the TMEM47 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell junction. Cell junction, adherens junction. Note=In undifferentiated cultured podocytes localizes to the perinuclear region and translocates to the cell membrane after Cadherin appearance at cell-cell contacts. Upon differentiation of cultured podocytes, protein disappears from cell contacts and expression ceases. Re-expressed upon induced podocyte injury. Colocalizes with FYB1 at cell-cell contacts in podocytes.
Protein: FOXP2_GORGO
Sequence: MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
What is the function of this protein?
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium.  May also play a role in developing neural, gastrointestinal and cardiovascular tissues.  Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.  Plays a role in synapse formation by regulating SRPX2 levels (By similarity).
What are the official names of this protein?
Forkhead box protein P2.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCEI_SALCH
Sequence: MKKNLLGFTLASLLFTTGSAVAAEYKIDKEGQHAFVNFRIQHLGYSWLYGTFKDFDGTFTFDEKNPSADKVNVTINTNSVDTNHAERDKHLRSAEFLNVAKFPQATFTSTSVKKEGDELDITGNLTLNGVTKPVTLEAKLMGQGDDPWGGKRAGFEAEGKIKLKDFNITTDLGPASQEVELIISVEGVQQK
What are the official names of this protein?
Protein YceI.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: PYRR_SYNFM
Sequence: MVENGSRVVMEARDIRSALERLAREIVEQPVDPNGLALVGIHTGGVFLAKRLETLISKKLKHSIPVGTLDITLYRDDWTRLHTQPVVRATNLPFPMDDRDVVLVDDVLYTGRTIRAALDALIDYGRPKRVQVAALVDRGHRELPICGQFIGIELKTRSDEQVNVLLKEKDGVDRVVIEQAAQARKA
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: SDHA_MESAU
Sequence: DHEFDAVVVGAGGAGLRAAFGLSEAGFNTACGTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSTTEDGKIYQRAFGGQSLKFGKGGQAHRSCCVADRTGHSLLHTLYGRSLRYDTSYFVENFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFIQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRSWGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQVVPGLYACGEAACASVHGAIRLGANSLLDLVVFGRACALSIAESCSPGDKVPPIKANAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRVDEYDYYXA
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).  Can act as a tumor suppressor.
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, Fp.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: YIDE_ECOSE
Sequence: MSDIALTVSILALVAVVGLFIGNVKFRGIGLGIGGVLFGGIIVGHFVSQAGMTLSSDMLHVIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIIGGLVTAILHKLFDIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPMEMVDQMGMSYAMAYPFGICGILFTMWMLRVIFRVNVETEAQQHESSRTNGGALIKTINIRVENPNLHDLAIKDVPILNGDKIICSRLKREETLKVPSPDTIIQLGDLLHLVGQPADLHNAQLVIGQEVDTSLSTKGTDLRVERVVVTNENVLGKRIRDLHFKERYDVVISRLNRAGVELVASGDISLQFGDILNLVGRPSAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPVFVPGFPAALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFVNTLVNGEGLSWIGYGALITAVPLITVGILARMLAKMNYLTMCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSIG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IML2_ASPTN
Sequence: MFKVGSWLYGKKPGTASTQSLDSLTELRDSATLILNDDVDGAEDGLSEGISSFHNLGRGVVAFIRATLGFEQEIMRQASERLNIAETSAASDQHKAQHNSHAPNTYHSQIYVPGTEFALCQAMAQLMSAVVGVLNESLTESIKGFYKMRKAYITLDGILKMEQKFMQMKRSGELSPPELAQSSSRSSGQGADAKSNPTTPVEAGGLSQKLSELNVSREPTDSDMSVETSSEMLSHDPDSDIFRNQIDVFVHSGANFCFGILLLLISMVPPAFSKLLGIIGFHGDKERGLKMLWQASKFHNLIGAIAAFAMLGYYNGFVRYCDIMPDPVSREEGDVQAYPQERLEALLAKMRKQFPKSQLWLLEESRMEGANKNLERALELLCGEERSPLKQVEALRVFERSLNAMYLHRYQLCSESFIECVDLNSWSRSLYYYIAGAAHVSLYRSALGKDASEATKHAEQATEYFRTAPPLAGKKRFMARQLPFDVFVARKIAKWEARAKEWKVPLVDAVGVDPIEEMIFFWNGHSRMTQAHLEESLQHLAWSESDANKHWSREGPEEKAILQLVRAAVLRSMRKHSEAKDLLQRGILDHDKSLFVGHLKDNWIGPAAHFEMAANLWMERPTYIEIHGGPDEENPGEDAHQLERNKVRQCKEYLEKAARWESYELDARIGLKVTAALEAVHKWETAHSATS
What is the function of this protein?
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins.  Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
What are the official names of this protein?
Inclusion body clearance protein iml2.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Protein: MU116_SCHPO
Sequence: MVSRVESVIVFALYKFLQRYFHSFHCFFLLCFTVMLCVVQQCSSAMTSFRCPTFSLSKYTCVLPASIPEMILFTFSSHTFQTPTKKGNKTKKKRKKEKKKETIVEKNKVLKSFALYKKINNYRSTRCVLVCQCKY
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 116 protein.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: LAPP_HAEOF
Sequence: MNSFLFSLACSLLVAIPAISAQDEDAGGAGDETSEGEDTTGSDETPSTGGGGDGGNEETITAGNEDCWSKRPGWKLPDNLLTKTEFTSVDECRKMCEESAVEPSCYILQINTETNECYRNNEGDVTWSSLQYDQPNVVQWHLHACSK
What is the function of this protein?
Inhibits collagen-stimulated platelet aggregation (IC(50)=60 nM), dense granule release and serotonin release (PubMed:1551898, PubMed:1551897).  Does not inhibit platelet aggregation induced by ADP, arachidonic acid, and thrombin (PubMed:1551897).
What are the official names of this protein?
Leech anti-platelet protein, LAPP.
What are the subcellular locations of this protein?
Secreted.
Protein: SYY_BORDL
Sequence: MNLSLKVLDKRGFLKQCTNLEELSTLMDREKIVFYVGVDATSASLHIGHLIPFMVMLHLQRQGHIPIILIGGGTTKIGDPSGKDSMRKILLKEDIDENVKTISSQLLKIIDLSNGGYILNNAEWLDGINYIEFLREVGIYFSVNRMLSFETYKRRLKDGLSFIEFNYQLLQSYDFYMLSRMKNCKLQIGGDDQWGNIVSGVDLVNRKSGNKVFGLTLPLITRSDGKKMGKSEKGAVYLDSELYSVYDFYQYFRNIPDLDVKKFLYLFTFLEEEEIERIASVKGQLLNNAKEILAFEITKIVHGKDEALKASSAAKAAFKGGDGRADIPFFKLELTNLEESILLVDLMVLAKVVSSKSEARRLIDSGGVYIDKVRVGDQNYCLCKDNFINGEIELKIGKKKILRIVL
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFPS_AERPX
Sequence: MLIDHYIMDFMSITPDRLSGASLHLIKAGGKRLRPLITLLTARMLGGLEAEARAIPLAASIETAHTFSLIHDDIMDRDEVRRGVPTTHVVYGDDWAILAGDTLHAAAFKMIADSREWGMSHEQAYRAFKVLSEAAIQISRGQAYDMLFEETWDVDVADYLNMVRLKTGALIEAAARIGAVAAGAGSEIEKMMGEVGMNAGIAFQIRDDILGVIGDPKVTGKPVYNDLRRGKKTLLVIYAVKKAGRREIVDLIGPKASEDDLKRAASIIVDSGALDYAESRARFYVERARDILSRVPAVDAESKELLNLLLDYIVERVK
What is the function of this protein?
Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C25-C25 diether (2,3-di-O-sesterterpanyl-sn-glycero) membrane lipid.  Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield all-trans geranylfarnesyl diphosphate (GFPP).  Geranylgeranyl diphosphate (GGPP) is the preferred substrate, however methylallyl diphosphate (DMAPP), farnesyl diphosphate (FPP) and geranyl diphosphate (GPP) can also be used as allylic substrate.
What are the official names of this protein?
Geranylfarnesyl diphosphate synthase, GFPS, Farnesylgeranyl diphosphate synthase, FGPP synthase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: IND1_STRGR
Sequence: MTRTDFAQSAVASIFTGAIASHAAVLADDLGLFDALAKGKLRNRDLDRSPWLRNRIRISGALEALCRVGAVQRCTDGYELTDVGTELAGQVPVFRLWLGGYASVLAGQISIGADPATGVHGGIVAESSGAIGARYLDETIVNLLESLRPEGRICDIGCGTGARLLRVCRRVNQPGIGYDLSAKAVEAARETVDEARRIGVDIDVRQGDATALTQDHPDVDIVTQAFMTHHIAPDEYCAAVLRSYRSRFPRARYLVIFDTVPSQDSEEPEIFAPGFDYIHALQNMEPRSRGAARRMFTEAGYICREEVELAVPNSYAWVLEMRDREGPAS
What is the function of this protein?
Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases.  Catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to position 3 of the aliphatic side chain of (indol-3-yl)pyruvate to yield 3-methylindolepyruvate.
What are the official names of this protein?
Indolepyruvate C-methyltransferase, S-adenosylmethionine: indolepyruvate 3-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: MUTL_BACCR
Sequence: MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIKGYVTLPEVTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEETLQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKEPSMPDIVLPTGMDAKQEEPQAVKQPPQLWQPPKQEWQPPQSLIREEQSWQPSTKPIIEEPIQEEKSWDSNEEDFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYMIDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.