PharMolix/UniProtQA huggingface dataset:
Protein: PI5K2_ARATH
Sequence: MMREPLVSEEEEEEATEVLLVEKTKLCKRRGDEEKTEERRDDLLLLALTPMVRSKSQGTTRRVTPTPPPVDVEKPLPNGDLYMGTFSGGFPNGSGKYLWKDGCMYEGEWKRGKASGKGKFSWPSGATYEGEFKSGRMEGSGTFVGVDGDTYRGSWVADRKQGHGQKRYANGDYYEGTWRRNLQDGRGRYVWMNGNQYTGEWRNGVICGKGVLAWPNGNRYEGQWENGVPKGSGVFTWADGSSWIGSWNESSNLMRNFFDGIEKNELIVATRKRSSVDSGAGSLTGEKIFPRICIWESDGEAGDITCDIVDNVEASVIYRDRISIDKDGFRQFRKNPCCFSGEAKKPGETISKGHKKYDLMLNLQHGIRYSVGKHASVVRDLKQSDFDPSEKFWTRFPPEGSKTTPPHLSVDFRWKDYCPLVFRRLRELFTVDPADYMLAICGNDALRELSSPGKSGSFFYLTQDDRFMIKTVKKSEVKVLLRMLPSYYKHVCQYENTLVTRFYGVHCIKPVGGQKTRFIVMGNLFCSEYRIQRRFDLKGSSHGRYTSKPEGEIDETTTLKDLDLNFAFRLQRNWYQELMTQIKRDCEFLEAERIMDYSLLVGVHFRDDNTGDKMGLSPFVLRSGKIESYQSEKFMRGCRFLEAELQDMDRILAGRKPLIRLGANMPARAERMARRSDYDQYSSGGTNYQSHGEVYEVVLYFGIIDILQDYDISKKIEHAYKSLQADPASISAVDPKLYSRRFRDFISRIFIEDG
What is the function of this protein?
Possesses phosphatidylinositol (PtdIns) phosphate kinase activity (Probable).  Phosphorylates PtdIns(4)P and PtdIns(3)P in vitro (PubMed:19903693).  Doesn't phosphorylate PtdIns(5)P nor PtdIns(3,4)P2 in vitro (PubMed:19903693).  Does not exhibit phosphatidylinositol kinase activity in vitro (PubMed:19903693).
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase 2, AtPIP5K2, 1-phosphatidylinositol 4-phosphate kinase 2, Diphosphoinositide kinase 2, PtdIns(4)P-5-kinase 2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: HSLV_SHEFN
Sequence: MTTIVSVRRNNQVVIAGDGQVSLGNTVMKGNARKVRRLYHNKVLAGFAGGTADAFTLFERFEAKLEMHQGHLLKSAVELAKDWRSDKMLRKLEAMLVVADTESSLIITGNGDVVQPEYDLIAIGSGGNYAHASALALLQNTELSAEEIAEKSLTIAGDICVFTNQFKTIEKLDY
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCP60_MOUSE
Sequence: MAAQLNVEQLEVSLDGLTLSPDSEERPGAEGAPPQTPPSSAPGNGLGSGASGQQREPGEAAAEGAAEEARRMEQHWGFGLEELYGLALRFYKIKDGKAFHPTYEEKLKFVALHKQVLLGPYNPDTSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCPLLSAYVASHRIEKEEEEKRRKAEEERRQREEEERERLQKEEEKRKREKEDRLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVMAGASLPASSKVNTAGASDTLSVNGQAKTHTENSEKVLEPEAAEEALENGPKDSLPVIAAPSMWTRPQIKDFKEKIRQDADSVITVRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSDEEEEEEENVTCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR
What is the function of this protein?
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity).  Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (PubMed:12711385).  Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity).
What are the official names of this protein?
Golgi resident protein GCP60, Acyl-CoA-binding domain-containing protein 3, Golgi complex-associated protein 1, GOCAP1, Golgi phosphoprotein 1, GOLPH1, PBR- and PKA-associated protein 7, Peripheral benzodiazepine receptor-associated protein PAP7.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Note=Also mitochondrial (via its interaction with PBR).
Protein: HPRK_BURM9
Sequence: MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: PYRH_METKA
Sequence: MYSVVALGGSVVNVDKPERIKETAEILRNGLDSGLKICVVVGGGPTARRYINVARNLGTPETLLDEMGIAVTRLNAMLLGAALGLHDLHVPETPVEAARIVRRNGVAVCGGTHPGHTTDAVAAMIAELLEGPLVIVTNVDGVYDKDPSEPGARKLRELRPEELEELAVRAELKAGGSFVVDPLAAKMISRGQIVTHVVSWEDFRSRGLENVVRGRHNGTIIEG
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP1_BRADU
Sequence: MPIDRRAGSVKRRRIKFRDEAFSIHMTASITSTETQEGPVTSGFWALTLGSIGVVFGDIGTSPLYAFHEAVRGAAHGEPVTRVMVLGVLSLILWALLIVVTAKYVLLLLRADNNGEGGTLSLMALGQRALGRRSWFLLALGVVGASMFIGDSMITPAISVLSAVEGLKLATPALEHYVVPLTVLILVLLFAVQSKGTALVASAFGPVMVVWFTCIAVMGAVHIADDPSVLAAINPYYALQFLLSHGTIGLVTLGAVFLAVTGGEALYADLGHFGRKPIQAAWMFFVLPSLLINYFGQGALVLSDPSAIEHSFYRMVPEHLVLPLVGLATAATVIASQAVITGAYSLVYQAVQLGLLPRFEVRYTSESHAGQIYLPRVNRLLLIGVMLLVLLFHTPSNLASAYGIAVSTTMVADGIMGFVVIWKLWNWRAATAAAVILPFVVVDMSFFSANLLKLLEGAWVPLLFGAAMAGTIWTWRRGSGILIQKTRRIEVPLDDLIRSLEKRPPHIVKGTAVFLTSDPSFVPTALLHNLKHNKVLHEHNVVLTIETAHTPRVDLSERFRMEKISDKFSKVRLRFGFMEQPNVPKALAIARKQGWQFDIMSTSFFVSRRSLKASAQSGMPLWQDHLFIALSRSANDATDYFQIPTGRVVEVGTQVTI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYH1_BACCR
Sequence: MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDEILKEIYTLQDQGKRELALRYDLTIPFAKVVAMNPNLRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMAMAFELFRTLNLEITIQYNNRKLLNGILESINIPTELTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSCLKLTIADFKEAFNNPLVADGVNELQQLQQYLIALGINENTIFNPFLARGLTMYTGTVYEIFLKDRSITSSIGSGGRYDNIIGAFRGDNMNYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELQCLQIAQQLRSTTSLKVELELAGRKLKRALNYANKENIPYVLIIGEDELSTNTVVLRNMKEGSEVKVPISSLSRYL
What are the official names of this protein?
Histidine--tRNA ligase 1, Histidyl-tRNA synthetase 1, HisRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM10_SCHPO
Sequence: MSMFGIGKNNQTINPQNIAMAEQEVEMMSDIFNRLVMTCHKKCISPKYYEADLTKGESVCIDRCVSKYFEANQSLSQHMQKRGQENPTP
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim10.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: DNLJ_PROMM
Sequence: MTPTSITPPKRAAELRQLLNQAAHSYYVLDTPTMEDAVYDRLYRELLNLEAKDSSLLTPDSPTQRIGGAPAQGFASVQHRIPLLSLDNAFNVDELTGWYVRLAKLLGHQTNPKTPQPDLSMVGELKIDGNALALSYEHGVLIRAATRGDGANGEEITANVRTIASIPLRLQLVHPPAWLEVRGEAFIPNSTFADINTARGKRGDVAFANPRNACAGTLRQLDPKVVASRQLDFFAYTLHLPDNWQAKAHDPARPMNQWAALQWLQAIGFKVNPNTALLADLTAVENFFKLWDEDRHQLPYATDGVVVKLNDLQLQETAGFTQKAPRWAIALKYAAEEAPSKLLRLTCQVGRTGAVTPVAEFEAIPLAGTSVSRATLHNANRVSELDLHSGDTIVVRKAGEIIPEVIGVLRELRPAGAQTLKLPHICPECRSDLVREEDEAATRCVNSSCPAILRGTLRHWVSKGALDVDGLGSKLIEQLVNRGLVQSIADLYALEASLLASMDRMGSKSTANLITALQASKSKPWHKQLYGLGIHHVGEVNAKALAKKFPSAATLATAACKAPEQITSVFGVGNEIAQSLQQWFATPANQQLLAKLKQLGISLEANEDELAHDTDQNQRTVSLEGQTFVLTGTLPTLSRSEAQALIEASGGKVNNSVSKNTSYVVAGVAAGSKLNKAEKLEVTVLNQEELLKLLAS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: GAP1_SCHPO
Sequence: MTKRHSGTLSSSVLPQTNRLSLLRNRESTSVLYTIDLDMESDVEDAFFHLDRELHDLKQQISSQSKQNFVLERDVRYLDSKIALLIQNRMAQEEQHEFAKRLNDNYNAVKGSFPDDRKLQLYGALFFLLQSEPAYIASLVRRVKLFNMDALLQIVMFNIYGNQYESREEHLLLSLFQMVLTTEFEATSDVLSLLRANTPVSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTGQLSPSEDDNLLTNEEVSEFPAVKNAIQERSAQLLLLTKRFLDAVLNSIDEIPYGIRWVCKLIRNLTNRLFPSISDSTICSLIGGFFFLRFVNPAIISPQTSMLLDSCPSDNVRKTLATIAKIIQSVANGTSSTKTHLDVSFQPMLKEYEEKVHNLLRKLGNVGDFFEALELDQYIALSKKSLALEMTVNEIYLTHEIILENLDNLYDPDSHVHLILQELGEPCKSVPQEDNCLVTLPLYNRWDSSIPDLKQNLKVTREDILYVDAKTLFIQLLRLLPSGHPATRVPLDLPLIADSVSSLKSMSLMKKGIRAIELLDELSTLRLVDKENRYEPLTSEVEKEFIDLDALYERIRAERDALQDVHRAICDHNEYLQTQLQIYGSYLNNARSQIKPSHSDSKGFSRGVGVVGIKPKNIKSSNTVKLSSQQLKKESVLLNCTIPEFNVSNTYFTFSSPSTDNFVIAVYQRGHSKVLVEVCICLDDVLQRRYASNPVVDLGFLTFEANKLYHLFEQLFLRK
What is the function of this protein?
Inhibitory regulator of the Ras-cyclic AMP pathway.  Stimulates the GTPase activity of Ras1.
What are the official names of this protein?
GTPase-activating protein, Ras GTPase-activating protein.
Protein: RPOA_ENTFA
Sequence: MIEFEKPRIEKIDENRDYGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAITNIQIDGVLHEFSTIPGVREDVTQIILNIKGLALKLYAEEEKTLEIDITGPATVTAGDIIVDSDVEILNKDLVICSVAEGATFHARLTVKPGRGYVQADENKKEDMPIGVLPVDSIYTPVLRVNYQVENTRVGRRDDFDKLTMEIWTDGSIIPQEALSLAAKIMTEHLDIFVNLTDEAKNAEIMVEKEETQKEKMLEMTIEELDLSVRSYNCLKRAGINTVQELTNKSEPEMIKVRNLGRKSLEEVKLKLHDLGLGLRKDD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RLMH_AGRVS
Sequence: MRIGIVAVGRLKAGPEKDLVSRYLDRFAKAGPASGLEFSRVNELPESRASNSATRKREEAVQIEKSLPDNPLVVALDERGKSWDSQEFATYVGDHKDRGRRDMVIVIGGADGLDPDFRDRADLVLNLGKMTWPHQLVRIMLAEQLYRAVTILSGHPYHRS
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_ARCFU
Sequence: MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASSYAEWEEILAKTECSFAQVHSEMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHLILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVREAIRFVRPMGVDVSSGVERDGLKDEMLVREFVRRAKNEVR
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: TRPD_TRIL1
Sequence: MIRQAIAKVVELRDLSEGEMIEVMNQIMSGECTPAQIGSFITALRMKGETIAEISGAARVMRERATPIRVGRNVLDIDRDDINLDQETILDVVGTGGDGTNTFNISTTVSFIVSACGVKVAKHGNRSVSSACGSADVLEKLGVNLDVTPEQVERCINEIGIGFLFAPALHGAMKHAIGPRREIGIRTIFNILGPLTNPANADCQVMGVYREELVAKMAGVLHHLGCKRGFVVHGRDGMDEITLTGETAAAEVSPEGVRLFTITPEEFGFSRCSMQALKGGDAVANAAIVRAVLGGEPGPRREIVLLNAGFALLAAGRCATVAAGIDLAAQAIDSGAALMQIEKLATLTN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: AIGLC_ARATH
Sequence: MLSGKAAYDLFVYGSLQEPEVVYVLLNRVPDHVSAVLSGFHRFRLKGRVYPTILPDGTGKVNGKVLKGITDDELKMLDEFEDVEYDRKTVEVMLTDTSEKLQVETYVWKNKDDPDLYGEWDFEEWRQHDKEDFVTATKKFLENRRLPEAKTRMDTFKTFFKQDLENGKPLDS
What is the function of this protein?
Putative gamma-glutamylcyclotransferase.
What are the official names of this protein?
AIG2-like protein C, Avirulence-induced gene 2-like protein C, Putative gamma-glutamylcyclotransferase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family.
Protein: RPIA_YARLI
Sequence: MSSELPPLEQAKRIAAHQAVEQHYPKDAKVVGIGSGSTVVYVAEKIASLPKELTKDTVFISTGFQSKQLIQNAGLRLGCIDQYSNGDLDVAFDGADETDPQLNCIKGGGACLFQEKIVAECARKFVVVADYRKQSKALGTVWIQGIPIEVVPDAYNKVIADLKKMGAQSAVLRPGSPGKAGPIITDNGNFIVDAYFGEIQPDAVKDLHIKIKLLLGVVETGLFTNADVAYFGNADGTISTITK
What are the official names of this protein?
Ribose-5-phosphate isomerase, D-ribose-5-phosphate ketol-isomerase, Phosphoriboisomerase.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_RUBXD
Sequence: MAQTLYTGTGRRKTSVARVRVLPGDGRITVNGRPVEEYFPRVTHQRAVRAPLELLDAAGRYDVVAKIEGGGPTGQAEALRHGIARALAEESPEARGELKAAGLLTRDARAVERKKYGLKKARKRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: IF6_NANEQ
Sequence: MRVNKIKIYGSDSIGLFGYIANDIAVLSEVISKEEEKIIKDTLGLEGIVKTTIAGTPTVGSFIIGKKDLIIVPSSIYEEELKKLEELFRVEVVDVVNNALGNNYYYWPKKNLLFAAEDTKKEAKLLAKKLNADLYLIDTDIEVGSSLIGNSKMLLHNPDIYIDIEDAKPVTLNMGDKFVGAAALLNDKGIVVGSKTTGIELIELQDLF
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: UBE2S_DROYA
Sequence: MSSQYSNVENLSPQTIRQVMRELQEMETTPPEGIKVLINESDVTDIQALIDGPAGTPYAAGVFRVKLTLNKDFPQTPPKAYFLTKIFHPNVAANGEICVNTLKKDWKPDLGIKHILLTIKCLLIVPNPESALNEEAGKMLLERYDDYSQRARMMTEIHAQPAKCGVGASGDAKDDDGPSTKKHAGLDKKLQDKKKEKLLKEKKRMLKRL
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.  Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 S, E2 ubiquitin-conjugating enzyme S, Ubiquitin carrier protein S, Ubiquitin-protein ligase S.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: MLCF_PENCI
Sequence: MSPARITDFSPGKPRKALLCIHGAGCSAAIFRVQISKLRVALKNEFEFVYATAPFSSSPGPGVLPVFQGMGPYYTWFQKHHDAVTNTTTPTVGDRVAAVIGPVQKTVQDWSITNPQAPIVGIVAFSEGALVATLLLHQQQMGKLPWFPKMSIAVLICCFYSDEARDYMRAEAQDDDDKLIINVPTLHLHGRQDFALQGSRQMVETHYLPQNADVLEFQGKHNFPNRPSDVQETVKRFQQLYQKVKMSGSFV
What is the function of this protein?
Esterase; part of the gene cluster that mediates the biosynthesis of compactin, also known as mevastatin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803, PubMed:12242508).  Compactin biosynthesis is performed in two stages (PubMed:12172803).  The first stage is catalyzed by the nonaketide synthase mlcA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:12172803).  This PKS stage is completed by the action of dehydrogenase mlcG, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mlcA-mediated biosynthesis of the nonaketide chain and leads to dihydro-ML-236C carboxylate (PubMed:12172803).  Covalently bound dihydro-ML-236C carboxylate is released from mlcA by the mlcF esterase (PubMed:12172803).  Conversion of dihydro-ML-236C carboxylate into ML-236A carboxylate is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mlcC (PubMed:12172803).  Finally, mlcH performs the conversion of ML-236A carboxylate to ML-236B/compactin carboxylate through the addition of the side-chain diketide moiety produced by the diketide synthase mlcB (PubMed:12172803).
What are the official names of this protein?
Esterase mlcF, Compactin biosynthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the LovG family.
Protein: Y043_HAEIN
Sequence: MEKQIFEHSVNVEEEHYQPKQEFHNMEAKLDEALDGELLDAQLEQALKPKSSFRKTLLKFTALLFGLATVAQSVQWIWDSYQKHQWIYLAFALVSLIIILLGIKEIICEWRRLVRLKKREQWQQQSQQIWLESAVKNGDVFSVHNAEKSKILCLDIAKSLGLENDSPTVIQWQHQLNEAYSAQEIAHLFSRHVLSSFDAQAKKLISKMAAESAVIVAISPLAVVDMFFIAWRNLRLMNKIAEIYGIELGYFPRIRLLRMVLVNIAFAGATEVAQDIGMDWLSQDVTAKLSTRIAQGIGVGLLTARLGVKAMELCRPLAFQLNEKPKLSHIQQELLSSVKDIVLGKNKIYKKEQI
What are the official names of this protein?
UPF0283 membrane protein HI_0043.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RRF_ECODH
Sequence: MISDIRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMSPAVEKAIMASDLGLNPNSAGSDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKIEAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: ERB1_SCHPO
Sequence: METGMNRKRSRSKRANSNVGVEKDKEKEKSKGVSNVPNEVETESSSHEPSFKKDVDEEIPSLTAELSEEEEGEYSSESGRSTPELSPDDFEDADDEEEFEEIDAGYSSDSSTEDVAPGLYESPYDENLYINYDIDGKKITRPATPAALDSLIASIDKDKGWTGIVDPMTGKPVNLTTEELGLLKRLAQSEIPDENFDPYPDYDDFFTNTVRETPLSSAPEPKRRFAPSKHEQKRILQLAYAIRKGRILTSEQRAERERESQSNYADHDLWADDDQATVNQRKLDYAPAPKLPPPSHEESYNPPEEYLKQSSDFPKKYKSLRVVPAYSNLIKEKFERCLDLYLAPRVRRTKLNIDPESLLPKLPTPSELRPFPTRCTNVFIGHKGRVRCLSVHVSGNWLASGGDDGVLRIWEVMTGRCVWKCSLDSFGNAHNIDSDEDAVNESLSHSTKSSIIQSLAWGPLSDSPVLAVAVDETVYFITPPIFSDEQIEASKELFTSAPYQESSAIWRRGAKQSLQLHGGIVHATVSTPSSIKSLSWHRRGDYLATSSPTSSSQAVLIHQLSRGASQSPFSKSKGSVQAVTFHPTMPYLLVATQRYVRIYNLVKQELVKTLLTGVKWVSSLSVHSSGDHVIIGSYDKRLCWFDLDFSSKPYKNLRYHSRALRDVSYHPSLPLFCSGSDDGDVQVFHGRVYSDLLANPLIVPLKILRNHKVVDNVGVLSTCWHPKEAWLFSAGAGGEIRMWT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein erb1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: GLYM_BOVIN
Sequence: MLSFSFIWATRPLRRCGQLVGMAVRCQHSEAAQTQTGEASKGWSGQESLSDSDPEMWELLRREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFKPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVQAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQILKNAQAMANALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRGFLEDDFRKVVGFIDEGVNIGLEVKSKTTKLQDFKSFLLKDPETSHQLADLRQRVEQFARAFPMPGFDDH
What is the function of this protein?
Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis.  Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate.  Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA.  Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs.  Associates with mitochondrial DNA.  In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
What are the official names of this protein?
Serine hydroxymethyltransferase, mitochondrial, SHMT, Glycine hydroxymethyltransferase, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane. Cytoplasm. Nucleus. Note=Mainly localizes in the mitochondrion. Also found in the cytoplasm and nucleus as part of the BRISC complex.
Protein: PA2H1_BOTDP
Sequence: SLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKEATQRCCYVHKCCYKKLTGCDPKKDRYSYSW
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity.  Is myotoxic, induces edema, and causes systemic effects (renal changes that lead to proteinuria) on mice (PubMed:29170054).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog BdipTx-I, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.