PharMolix/UniProtQA huggingface dataset:
Protein: BARX1_HUMAN
Sequence: MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLSSALLAAGPGLPGAAGAPHLPLELQLRGKLEAAGPGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPGEPSDRSRED
What is the function of this protein?
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis.  May have a role in the differentiation of molars from incisors.  Plays a role in suppressing endodermal Wnt activity (By similarity).  Binds to a regulatory module of the NCAM promoter.
What are the official names of this protein?
Homeobox protein BarH-like 1.
What is the protein family that this protein belongs to?
Belongs to the BAR homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDC45_SCHPO
Sequence: MFIKRSDYASAYLKIKEASVSGGCTVQLFVALDPDALCACKLLSTLLKGDFISHKIRPVSGYRDLEQANKTLLEQNEDIKFIILLNCGTMVDLNNYLVSMEDVSIYVIDSHRPHNLNNIYIENNIFVFDDGDIEEDMNKIHDAWYAFNSHELSDEENSDSSNEREEEVEDDNRSVESYSSSDYQARSRRRFSEETTQRRAEIKEKRKKRKEFASILSEYYEKGSWYGESITNILFAVASMLGREDNDMLWLAIVGLTCLEIHCQSSKKYFNRSYSLLKDEVNRLNPSPLENQIVGRAHGKTPHDQSIRLEDEFRFMLVRHWSLYDSMLHSAYVGSRLHIWSEEGRKRLHKLLAKMGLSLVECKQTYIHMNMDLKKTLKSSLKRFAPFYGLDDVIFHSFTRTYGFKCTLSASDVSYAISALLEMGNTGVLLQSKTVARSPDMTEEEYLEKFENAQNQEWLHNFYDAYDALDDVDSLERALKLAMHLQRAIVRTGITLLEKRAIKTLRSFRFGLINEGPDLKIFMHPLALTKMSLWIAEAINEQEREFGKLRHLPLVLAAFVEEKNRYLIVGTSTSAFTSNEDDDDDDGHGHNRFGVAFQEVANMTSATLQMDCFEASVIECQKSDLGVFLESLSFKTLL
What is the function of this protein?
Required for initiation of chromosomal DNA replication.  May have a role in regulating the MCM proteins nda1 and nda4.
What are the official names of this protein?
Cell division control protein 45 homolog, Suppressor of nda4 protein.
What is the protein family that this protein belongs to?
Belongs to the CDC45 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FTHS_CLONN
Sequence: MKSDIEIAQSANMKKIADIAKELGLGEDDIELYGKYKCKISLDVLKNKHNEADGKLILVTAINPTPAGEGKSTITVGLGQALCKLHKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNTLKIDSRRILFKRVMDMNDRALRHIVVGMGGKVNGFLREDGFTITVASEIMAILCLSNSLMDLKERFGNILVAYNLDGEPIYCKDLNVHGAMAMLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILATKMAMKLGDYAITEAGFGADLGAEKFLDIKCRYGNLKPDCIVVVATIRALKHHGGVSKDELSTPDIEALSKGVSNLQKQIENMKKYGVPVVVAINKFITDSDEEVEFIKEFCDKQGVEVALAEVWEKGGEGGIALAEKVINVLDTQKSNFKCLYDEKLSIKEKMDIIAREIYGASGVDYDKSAEKDIKDIEKLGLDKLPICVAKTQYSLSDNPSLLGKPEDFRVNVREVKVSNGAGFIVVLTGNIMTMPGLPKVPAANKMDILEGGTIQGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: MIAA1_PHOV8
Sequence: MPDTLIVLIGPTGVGKTELSLSIAEHFRTSIVSADSRQLYADLKIGTAAPTPEQLARVPHYFVGTLQLTDYYSAAQYEADVLAQLEILYQNHDTVILTGGSMMYIDAICKGIDDIPTVDNETRQLMLRRYEQEGLDTLCAELRLLDPEYYKIVDLKNPKRVIHALEICYMTGKTYTSFRTRTHKERPFRIIKIGLTRDREELYDRINRRVDIMMQDGLLEEARQVYPFRHLNSLNTVGYKEMFKYLDGEWTLEFAIGKIKQNSRIYSRKQMTWFKRDKDIVWFHPDQQTEIMQYIHSVNH
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 1, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 1, DMAPP:tRNA dimethylallyltransferase 1, DMATase 1, Isopentenyl-diphosphate:tRNA isopentenyltransferase 1, IPP transferase 1, IPPT 1, IPTase 1.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: T3G1D_AGEOR
Sequence: MKAAISLLLLSALLFVVIEAITYEEGKELFQGERTDCVGDGQRCADWAGPYCCSGYYCSCRSMPYCRCRSDSGK
What is the function of this protein?
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects.  Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.  This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons (By similarity).
What are the official names of this protein?
U3-agatoxin-Ao1d, U3-AGTX-Ao1d, Mu-2Aga_05.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 02 (aga-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MSBA_PSEPF
Sequence: MTDSSPAASPSSLKIYFRLLGYVRPYISLFLISIVGFLIFASTQPMLGYILKYFVDGLSNPEAVLFPTVPYLRDLQLLQAVPLLIILIAAWQGLGSYLGNYFLAKVSLGLVHDLRVQLFNNLLVLPNRYFDKHNSGHLISRITFNVTMVTGAATDAIKVVIREGMTVIFLFASLLFMNWKLTLVMVAILPLIAVMVRTASKKFRKQSKKIQLAMGDVTHVASETIQGYRVVRSFGGEAYEEKRFLDASQGNTDKQLRMTRTGAIYTPLLQLVIYSAMAILMFLVLYLRGDASAGDMVAYITLAGLLPKPIRQLSEVSSTIQKGVAGAESIFEQLDVEPEVDTGTVERDSVSGRLDVRNLSFTYPGTERQVLDDISFSVEPGQMVALVGRSGSGKSTLANLIPRFYHHDKGEILIDGVEVEQYKLLNLRRHIAQVTQHVTLFSDTVANNIAYGDLAGAPREDIEKAARDAYAMDFIAQLPEGLDTQVGENGVLLSGGQRQRLAIARALLKNAPLLILDEATSALDTESERHIQAALDQVMKGRTTLVIAHRLSTIEKADLILVMDQGRIVERGTHDDLLAQNGYYARLNAMGLDAPAEDIA
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EXPA9_ORYSJ
Sequence: MEKKLLVVLFLSLCCASRLRGEAAQQWTSATATFYGGSDASGTMGGSCGYGNMYSAGYGTNTTALSSALYGDGASCGACYLVTCDASATRWCKNGTSVTVTATNYCPPNYSESGDAGGWCNPPRRHFDMSQPAWEAIAVYSSGIVPVRYARTPCRRVGGIRFGIAGHDYYELVLVTNVAGSGAVAAAWVKGSGTEWLSMSRNWGENWQSNAYLTGQALSFRVQADDGGVVTAYDVAPANWQFGSTYQSDVNFSY
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A9, Alpha-expansin-9, OsEXP9, OsEXPA9, OsaEXPa1.19.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: CLPP_FRATW
Sequence: MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGVYDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHHTGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COLA_VIBVU
Sequence: MSHLLPFPRRRLALACLLASISGASFGQTQCDVAQLQQSPDLATAISSADYACYSGWFSASSDTLNNIYSEASLSRVQVALHQAVQTYQGEAEQARAIENLGEYVRAAYYVRYNAGNVAAFSDLLGQQFAHTINAFLANPHALDQGREQVGAMKSLTLMVDNIKQLPLTMDAMMLALQQFNPETAKNTQWVDGLNNLFRSMAGHIANDAFYRYLASNTQHIDMLEKFANDNAWALDTDADFLVFNALRETGRLIASPDKATKQKAVQVMQRVMARYPLGSEHDKLWLAAVEMLSYFAPEALNGLDLPQAKRDLAARVLPNRHECQGPAIIRSQDLTPEQAAKACDVLAAKEADFHQVANTGMQPVADDHNQRVEVAVFANNDSYVDYSAFLFGNTTDNGGQYLEGNPADEHNTARFVAYRYANGEELSILNLEHEYTHYLDARFNQYGSFSDNLAHGYVVWWLEGFAEYMHYKQGYQAAIELIAQGKMSLSQVFATSYSHDTNRIYRWGYLAVRFMLENHPQEVEGLLALSRSGQFEQWAQQVQTLGQQYDGEFARWLDGLEVTPENPDTDPDTPTEPSDGVTQLQANQSITLSGKAYSEKLFYVDVPANTTHFSVAIEGDGDADLYMSYNQVAHYYDFEVSKFVDGSNEEIQFAADASGYVKPGRYYLSVTGRGRYQAVNLTATIDTAAPTPPTQEQDDLAPVMLQSGQAQHLTVHQQRYAAVYVPEGVSEVRIWLSDLTSSDSQGNVNLYASREHWPTPEQHQFASRYAGSNQYLAIPVEQAGYLHFSLNAPQQGDDVEMVVYFH
What is the function of this protein?
Possesses gelatinolytic activity.
What are the official names of this protein?
Microbial collagenase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M9A family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPO12_ORYSJ
Sequence: MAEAGVAAASLFGADRRLCSADILPPAEVRARIEVAVLNFLAALTDPAAPAISALPLISRGAANRGLRRALLRDDVSSVYLSYASCKRSLTRANDAKAFVRVWKVMEMCYKILGEGKLVTLRELFYTLLSESPTYFTCQRHVNQTVQDVVSLLRCTRQSLGIMASSRGALIGRLVVQGPEEEHVDCSILGPSGHAITGDLNVLSKLIFSSDARYIIVVEKDAIFQRLAEDRIYSHLPCILITAKGYPDLATRFILHRLSQTYPNMPIFALVDWNPAGLAILCTYKYGSISMGLESYRYACNVKWLGLRGDDLQLIPQSAYQELKPRDLQIAKSLLSSKFLQDKHRAELTLMLETGKRAEIEALYSHGFDFLGKYVARKIVQGDYI
What is the function of this protein?
Required for meiotic recombination.  Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).
What are the official names of this protein?
Meiotic recombination protein SPO11-2, OsSPO11-2, OsSPO11B, Topoisomerase 6 subunit A2, OsTOP6A2.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PATL6_ARATH
Sequence: MDASLSPFDHQKTQNTEPKKSFITSLITLRSNNIKEDTYFVSELKPTEQKSLQELKEKLSASSSKASSMWGVSLLGGDDKADVILLKFLRARDFKVADSLRMLEKCLEWREEFKAEKLTEEDLGFKDLEGKVAYMRGYDKEGHPVCYNAYGVFKEKEMYERVFGDEEKLNKFLRWRVQVLERGVKMLHFKPGGVNSIIQVTDLKDMPKRELRVASNQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKEGNAAETLYKFIRPEDIPVQYGGLSRPTDSQNGPPKPASEFSIKGGEKVNIQIEGIEGGATITWDIVVGGWDLEYSAEFVPNAEESYAIVVEKPKKMKATDEAVCNSFTTVEAGKLILSVDNTLSRKKKVAAYRYTVRKSTTTV
What is the function of this protein?
Carrier protein that may be involved in membrane-trafficking events associated with cell-plate formation during cytokinesis.  Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).
What are the official names of this protein?
Patellin-6.
What is the protein family that this protein belongs to?
Belongs to the patellin family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm. Note=Mainly membrane- associated. Also cytoplasmic (By similarity).
Protein: PYRF_CLONN
Sequence: MVLIIDRLYEEVNKKGNVCVGLDTDLSYIPQRFLKNYENIEDAIFQFNRKIIDATHDAVACYKVQIAYYESFGLKGLMAYKRTLEYIKKVGCIAISDVKRGDISKTAEMYAKAHFEGDFETDFITVNPYMGMDSIEPYMPYLQNKEKGLFALVRTSNPGSKDFEYIQSGSGRRVYEIVGEKLERLGEKVMGQCGYSSIGGVVGCTTLEDGKEIRKNFGKTFFLIPGFGAQGGGAKEANVYLKDGNGGVVNSSRGILLAYKKYENGEKNFDECSRKEVLKMQKELGRE
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: PSBJ_CERDE
Sequence: MADTTGRIPLWLIGTLTGIPVIGSIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: OBG_LACDA
Sequence: MPTPSTFVDQTKIEVQAGKGGDGMVAFRHEKFMPNGGPAGGDGGRGGSIIFVADNGLRTLMDFRYRRKFKAEPGENGRIKAQYGKAAKDLYLKVPVGTTVYDFFTGEEIGDLVENGQELVVAKGGRGGRGNIHFATSVNTAPEIAENGEPGEFRTLRLELKVLADVGLVGFPSVGKSTLLSVVTSAKPKIAAYQFTTLKPNLGMVLLPDGRDFSMADLPGLIKGASQGVGLGIQFLRHVERTKVILHMVSMDPNNGRDAYEDYETILHELASYTEDDLSSKREIIVASQMDIPGADEKLAQFKKDLAAHGVDQEVYELSSVTHQGVDRLMSRAADLVSEVEAQEAEAAVKPKEEVKTKTYKYHRPEKMEFTVEKLADHEFEIHGEQLERLVAMTNLDHQDGIMRLARRLKRMGVDDELRAQGAVDGDDVYIGDFSFEFVQ
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_VEREI
Sequence: MSAPLEHHTPMMAQYLALKGGYPETLLFYRMGDFYELFYADAEKAARLLNITLTQRGQSGGQTVVMAGVPFHALENYLTRLIKLGESVAIAEQVGEVGAAKGPLERKVVRVITPGTLTDTELLSDKAESLLLSLHQAARARCGLAWLSVTQGRVHLAECAHDELGAWLARVAPSEIIYSAGVTQRFEQQLQALRQSGAFDCPMRTRPDWQFDQALGERKLLEHLGAASLQAWDAQDLGAAQAAAAGLLAYAEHTQGRALTHVHSVQAQRGDELIDLPGSTRRNLELVKTLRGDDAPTLLSLLDNCMTGMGSRLLKTWLLEPHRERHQARQRLSASTALRGAAAGAGPWATLREQIKGASDVERITARIALRQVRPRELPGLVKTLQKAQLLAQHGQIPEPYLMQIFDQLHPPEGCAELLQAAIAEEPAALVREGGVIATGFDAELDELRALQTDCDGFLLDLETREKARTGIANLRVQFNKVHGFYIEVTSSNLERVPADYRRRQTLKNAERFITPELKAFEDKALSANERALVREKWLYEQILDRLQPHVPALTRLAQALATLDVLCTLAERSLTLNWCAPQFVSEPCIEIEGGRHPVVEARLAETASGSFIANHTRLNANTRMQLITGPNMGGKSTYMRQVALIVLLASIGSHVPASSCRLGPIDAIHTRIGAADDLANAQSTFMLEMTEAAHILHAATAHSLVLMDEIGRGTSTFDGLALASGIATHLHDKTRAFTLFATHYFELTDLPAKARHAINMHVSATESGADIVFLHEIQPGPASRSYGIQVAKLAGMPPPVLHHARRTLAALEERAGAGQLQVDLFAAPKEEPESKSASPVEAALAGINPDALSPREALDALYQLKRMAGK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PTUCB_KLEPN
Sequence: MLSQIQRFGGAMFTPVLLFPFAGIVVGIAIMLRNPMFVGEALTAPDSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAKQAQGRACLAVLVSFLTWNYFINAMGMTWGHFFGVDFSAEPTAGSGLTMIAGIKTLDTSIIGAIVISGLVTALHNRYFDKPLPVFLGIFQGSSFVVIVAFLAMIPCAWLTLLGWPKVQLGIESLQAFLRSAGALGVWVYIFLERILIPTGLHHFVYGPFIFGPAVVEGGLQVYWAEHLQAFSQSTEPLKTLFPEGGFALHGNSKVFGSVGIALALYFTAAPENRVKVAGLLIPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAATMATVMYICGVVGNFGGGLLDQFLPQNWIPMFHHHASMMFIQIGIGLCFTALYFVVFRTLILRLNLKTPGREESEIKLYSKADYQAARGKTTAAAAPETRLGQAAGFLQALGGADNIESINNCATRLRIALVDMAKTQSDDVFKALGAHGVVRRGNGIQVIVGLHVPQVRDQLENLMKDSLSTEHTTMTEAVS
What is the function of this protein?
Involved in the transport and simultaneous phosphorylation at O-6 of the glucosyl moiety of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses.  Can also transport maltose, isomaltose and maltitol, phosphorylating at O-6 of their non-reducing glucose portion.
What are the official names of this protein?
PTS system alpha-glucoside-specific EIICB component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EGR1B_XENLA
Sequence: MALAKTDMLVSPLQISDPFSSFPHSPTMDNYPKLDGAEQFDHHAADAFSEMSLSNEKAVLESSYANHTTRLPSLTYTGRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANVSSSSAPSSSPSSSSSSSSSSSSQSPPLSCSVQSNESSPIYSAAPTFPNSSPEMFPDHSPQPFQNASTASIPYPPPAYPVSKTTFQVPMIPDYLFPQQQGDVSLVSADQKPFQAMENRTQQPSLTPLSTIKAFATQTSQDLKTINSTYQSQIIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKATPVSIASPVSAYSPSASTSYPSPVPTSYSSPVSSCYPSPVHSSFPSPTTAVTYPSVTSTFQTQCITSFPSSIVTNSYSSPVSSALSDMSVTYSPRTIEIC
What is the function of this protein?
Transcriptional regulator.  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity).  Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity).  Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia.  Plays a role in the regulation of cell survival, proliferation and cell death.  Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity).  Plays a role in regulating the expression of circadian clock genes (By similarity).
What are the official names of this protein?
Early growth response protein 1-B, EGR-1-B.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DRS7B_XENTR
Sequence: MDLTTWAIFPLLLGSIGVYSLYKLLQRLRSGAYLQDAVVVITGATSGLGRECAKVFYAAGTRLVLCGRSEEGLKNLVQELSQMRIKSAQLHKPHMVIFDLSDVEAVNSAANEILHLTGRVDILINNAGISYRGTILDTKVSVDRMVMDTNYFGPVALTKALIPSMIKNRRGHIVVISSVQGKISIPFRSAYSASKHATQAFFDCLRAEMSPYEIDVTVVNPGYIKTNLSLNAVTGDGSNYGVMDNNTAEGRTPEEVAQTVLRAVGERRKELLVAGLVPTLAVYLRTLAPTIFFSFMAARAKKERKLKDS
What is the function of this protein?
Putative oxidoreductase.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 7B, Short-chain dehydrogenase/reductase family 32C member 1, Protein SDR32C1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: CODY_STRPJ
Sequence: MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_PHOLL
Sequence: MSTDSILTTVPIQWLSVDSPVLPDEVLDWLMELGSMTRRFEQYCNSVRIIPFRECFITEEQLSDENERLLTGQRYWLREIVLCGDNIPWLLGRTLIPETTLTGPDESLVDLGTVPLGRYLFSGNKLTRDYIHVGQQGNRWARRSLLRLSGKPLLLTEVFLPESPVYKR
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSF_EMENI
Sequence: MTPISVILVTDNKLTRPKTMSTTREKLLRTTSRFVSTFGSFDIEEILSIRTPTCLYHQCCPSFNKNVVTNEETRANFPQFIATFKRFDFSIIEPDHTLVDEAARRVMIRAKASAESIVGAYENEYIFILKMTDDCRFIEEIYEFYDTIRLKDLQYRLEAKHISYGDAAPFKTRDTQL
What is the function of this protein?
Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759).  Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759).  Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).
What are the official names of this protein?
Austinoid biosynthesis clusters protein F.
What is the protein family that this protein belongs to?
Belongs to the trt14 isomerase family.
Protein: DEF6_MACMU
Sequence: MRTIAILAAILLFALLAQAKSLQETADEAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCRCRFGRCFRRESYSGSCNINGRISSLCCR
What is the function of this protein?
Defensins 6 and 7 have bacteriostatic activity against Gram-positive bacteria S. aureus and L. monocytogenes and Gram-negative bacterium E. coli and antifungal activity against C. neoformans.  Defensin 7 has microbicidial activity against Gram-positive bacteria S. aureus and L. monocytogenes.
What are the official names of this protein?
Neutrophil defensin 6, RMAD-6.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NTPPA_ALIF1
Sequence: MEAQVFLASGSPRRKELLTQLGYQFDVLSVDVEEIHQEHETPLMYVERLSKDKAQAGVKAIEKTKNKYTPVLGSDTIVVIDGVILEKPKDFKDAKRMLLALSGRQHQVMTAVTIATPEKIRTKTVITQVWFKTLSEQEIEQYWESGEPCDKAGSYGIQGSGGRFVSRIDGSYHAVMGLPLMETDQLLHQFL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_DESHY
Sequence: MAKIAVYGAGSWGTALAVSMGKAGHEVALVGRNLSEMDLMEQRRENRPYLPGVVLPPTVRPTGDAGVLEEAEMLVLSVPSHSVRETAQKIRAYLQPGTIVVNTAKGLEEGSHKRLSQVLTEELPHHPIVVLSGPSHAEEVGKDMPTTVVVASQNSQAAEAVQDMLMTPKFRVYTNPDTIGVELGGAFKNIIALCAGFADGLGFGDNTKAALMTRGIAEITRLGAAMGGNPLTFAGLAGVGDLIVTCTSRHSRNHRAGVALGEGKPLEQVLKEVGMVVEGVRTTRVAYELSRQYEISMPITEQAYQVLFQGADPRAAVSALMMRGKKHEIEEVALIAMEQGSYQENGPDDHGE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMP_STAAB
Sequence: MKKKLFVLTMSTLFATQLINSNHANASTESVDKNFVVPESGINKIIPTYDEFKKAPKVNVGSLADNKNFVASEDKLSKIADPSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEVNRFITQNKVNHPFITTQTHYKKVITSYKSTHVHKHVNHATGSINKHFIVKPSEAPRYTQPSQSLMINHYFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSFQNNTTATHQNAKVKKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGEPSLNIKNVNYQYAVPSYSPTHYVPEFKGSIPAPRV
What is the function of this protein?
Adhesin that binds to the host cell extracellular matrix proteins fibronectin, fibrinogen, collagen, and vitronectin.
What are the official names of this protein?
Extracellular matrix protein-binding protein emp.
What are the subcellular locations of this protein?
Cell surface.