PharMolix/UniProtQA huggingface dataset:
Protein: SUB2_ARTOT
Sequence: MQLLNLGLLLLLPFVAGEIAPQPEPLRAGPSDIVPGQYIVTLKEGLASAQIREHKKWVSSVHQANLDSFAAGASGVETVGIMKNFHIHNLNMYSGGFDDKTAEDLRRSPDVKSVHPDQHVYLAKTVTQPQARWGLGYMSSKGMPVPLHSTLVDYLYDDKAGEGVWAYVLDTGINVDHIEFEDRGILGHNAIPNKPHTDEFEHGTYVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIVKNITDSNRKNKAVINLSISGAKYQPFDDAVENAFKAGITAVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSLASNYGKIVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSLENLPSPSAVTARVLNLTIPNLVKDAKDSPNRVVYNGIQERKFTLPKNTK
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_CALSH
Sequence: DPEYAIKETDLLALFRCTPQPGVDPVEAAAALAGESSTATWTVVWTDLLTACDLYRAKAYRVDPVPSAADTYFCYIAYDIDLFEEGSLANLTASIIGNIFGFKAVKALRLEDMRMPYALLKTYQGPATGLVVERERLDKFGRPLLGATVKPKLGLSGKNYGRVVFEGLKGGLDFLKDDENINSQPFMRYRERFLYSMEGVNHAAAMTGEVKGHYLNTTGATMEDMYERADFAKELGSVIVMIDLVIGYTAIQSMAKWSRKTDMILHLHRAGNSTYSRQKTHGMNFRVICKWMRMSGVDHIHAGTVVGKLEGDPLMIKGFYNTLLDFKTDVNLPQGLFFAQDWASLRKCVPVASGGIHCGQMHQLINYLGDDVVLQFGGGTIGHPDGIQAGATANRVALEAMVIARNEGRDYISEGPQILRDAAKTCGPLQTALDLWKDITFNYASTDTADFVETPTANV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MQO_PAEAT
Sequence: MTFISKTQHADVVLIGGGIMSATLGAFIKQLEPTWTISLFERLDEAGLESSGPWNNAGTGHAALCELNYSPAAKDGSVDPSKALHINEQFQLSRQFWSHLVDSNVIGSPKGFINTVPHMSFVIGDDHSNFLKNRYEALKPNTLFRSMEYTEDQDQIAKWAPLIVKGRDRKQRVAATRAAEGTDVDFGALTRELTGYLQSSGAEVNYGHDVTNIHRAAGGGWDLSIKHPKSGEHGRIHAKFVFVGAGGGALHLLQASGIPESKGYGGFPVSGQFFRCTDDAITSQHSAKVYGQASVGAPPMSVPHLDTRYVDGKRSLLFGPYAGFSTNFLKTSSYLDLPLSIRPGNIIPMLAVAKDNMDLTAYLIKEVAKRHEAKVEALREYYPEAAGGNWELITAGQRVQIIKKHPQKGGVLQFGTEVIASRDGSIGALLGASPGASTAVPIMIELLQKSFPKNFKGWQSKLKDMMPGYGVKLNENPDLAAELEASTARSLQLEVANAIQG
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: TMPB_LEICA
Sequence: MSKPDVSKLNRGNIVEFIGGIFDRRGDEEYLGEPVTMAEHMLQGATIAEQNGQPEEIIVGALLHDIGHFTSEFGMFSMDDTEDRYHEEAGAEVLEQFFPSVITDCVRYHVAAKRYLCATKPEYFNRLSEASIHSLKLQGGPMDAEEVAEFEKNPNLKQIIAVRYLDEAGKRADMETPDYWHFAPMVQRMVDKHMGA
What is the function of this protein?
Involved in the degradation of the naturally occurring organophosphonate 2-(trimethylammonio)ethylphosphonate (TMAEP) (PubMed:30789718).  Catalyzes the O(2)-dependent cleavage of (R)-1-hydroxy-2-(trimethylammonio)ethylphosphonate (OH-TMAEP) to yield glycine betaine and phosphate (PubMed:30789718).  Is highly specific for its N-trimethylated substrate (PubMed:30789718).
What are the official names of this protein?
[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming).
Protein: TAL_CHLPD
Sequence: MKFFIDTASLEEIQAAKDLGMLDGVTTNPSLIARIVGDASSFSYQDFREHIRRIAEIADGPVSAEVTTTDAEEMIHEGEALAAIHENVVVKCPLTIDGLKAIRHLSEKGIRTNATLVFSPNQALLAAKAGASYVSPFVGRLDDISTEGMALVEQIITIYDNYGYLTEVIVASIRHPRHVVESAMMGADIATIPFSVIRQLANHPLTDAGLKKFMEDAAILKKESDA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_IDILO
Sequence: MVTIRLQRGGAKKRPFYQMVVADSRNARDGRFIEKVGFFNPVARGQEEKLRVDVDRIEHWVSKGAQLSDRVAKLVKDASAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: YBEY_FRATN
Sequence: MDNLNINLINDDEHPIPSQDLLLKCLQLVADKHHISHAEVNLNIVSNDEIQQINKQFRNKDKPTNIISFEFEKPQGLPDDIANDFLGDIVIAPAVLENEAKEQNKELNDHWQHIFIHGLLHLLGYDHQDDQEAEVMENLEIQLLAQLGIANPYIEQENQNGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLE6_HUMAN
Sequence: MTSRDQPRPKGPPKSTSPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEEVSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPGLGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVTGSGEHASVYQITY
What is the function of this protein?
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248).  Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
What are the official names of this protein?
Transducin-like enhancer protein 6.
What is the protein family that this protein belongs to?
Belongs to the WD repeat Groucho/TLE family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: NAOX_LACLM
Sequence: MKIVVIGTNHAGIATANTLLEQYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFYAKAEDFEAKGVKILTETEVSEIDFANKKVYAKTKSDDEIIEAYDKLVLATGSRPIIPNLPGKDLKGIHFLKLFQEGQAIDAEFAKEKVKRIAVIGAGYIGTEIAEAAKRRGKEVLLFDAENTSLASYYDEEFAKGMDENLAQHGIELHFGELAKEFKANEEGYVSQIVTNKATYDVDLVINCIGFTANSALASDKLATFKNGAIKVDKHQQSSDPDVYAVGDVATIYSNALQDFTYIALASNAVRSGIVAGHNIGGKELESVGVQGSNGISIFGYNMTSTGLSVKAAKKLGLEVSFSDFEDKQKAWFLHENNDSVKIRIVYETKSRRIIGAQLASKSEIIAGNINMFSLAIQEKKTIDELALLDLFFLPHFNSPYNYMTVAALNAK
What is the function of this protein?
Catalyzes the four-electron reduction of molecular oxygen to water.  Active on beta-NADH, but not on alpha-NADH, beta-NADPH or alpha-NADPH.  Under aerobic conditions, oxygen acts as the electron acceptor.  Under anaerobic conditions, DCIP and MB can replace oxygen as the electron acceptor.
What are the official names of this protein?
NADH oxidase, NOXase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
Protein: ASNA_LIGS1
Sequence: MDLIIPKDYDPKLSIRETQEAIRYIRETFQDEFGKEMGLNRVSAPMYVEKSSGINDNLNGYEKPVSFTMKDMPGETIEVVHSLAKWKRMALKKYGFGLHEGLYTNMNAIRKDEDLDNFHSSYVDQWDWEKVISKDERNEKTLKETVELIFKVVKHMEHEVWYKFPNAVYHLPDKIHFITSQELEDKYPELEDAKDRENAICKELGCVFVMQIGDVLKSGKRHDGRAPDYDDWKLNGDILFWYEPLQCALELSSMGIRVDEDSMVEQLKKTGDEDRLKLQYHKMILNKELPYTIGGGIGQSRLCMLLLGKAHVGEVQASIWPDEMLKKCEENGIHIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPH_PSELT
Sequence: MNNDLTADSIIEMISSSKKKTPVIAYVKGHLSDIDMSGVQFFGTDNFGIIFADYEDLRQFLEKNGNKIHDVHIEAKARNSALPMADITKFNARVEPGAVIRDLVKIGDGAVIMMGAIINVGAVIGEKTMIDMNAVIGGRAIIGRNCHIGAGAVIAGVIEPPSATPVVIEDNVMVGANAVVLEGVKVGKGSVVAAGAVVVSDVDPYTVVAGIPAKFIKKVDEKTIEKTKIIEILRQRDH
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: LPTG_ECOLI
Sequence: MQPFGVLDRYIGKTIFTTIMMTLFMLVSLSGIIKFVDQLKKAGQGSYDALGAGMYTLLSVPKDVQIFFPMAALLGALLGLGMLAQRSELVVMQASGFTRMQVALSVMKTAIPLVLLTMAIGEWVAPQGEQMARNYRAQAMYGGSLLSTQQGLWAKDGNNFVYIERVKGDEELGGISIYAFNENRRLQSVRYAATAKFDPEHKVWRLSQVDESDLTNPKQITGSQTVSGTWKTNLTPDKLGVVALDPDALSISGLHNYVKYLKSSGQDAGRYQLNMWSKIFQPLSVAVMMLMALSFIFGPLRSVPMGVRVVTGISFGFVFYVLDQIFGPLTLVYGIPPIIGALLPSASFFLISLWLLMRKS
What is the function of this protein?
Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
What are the official names of this protein?
Lipopolysaccharide export system permease protein LptG.
What is the protein family that this protein belongs to?
Belongs to the LptF/LptG family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KIF4_XENLA
Sequence: MGKDEGIPVRVALRCRPLVPKENNEGCKMCLTFVPGEQQVIVGTEKSFTYDYVFDPSAEQEEVYNSAVAPLIKGLFKGYNATVLAYGQTGSGKTYSMGGAYTHNQENEPTVGVIPRTVIALFREIHQRPEWEFNLKVSYLEIYNEEILDLLYAARDKTNTISIREDPKEGIKICGLTERDVKTALDTLSCLEQGNSSRTVASTAMNSQSSRSHAIFTISIEQRKEGDKNNSFRSKLHLVDLAGSERQKKTKAEGDRLKEGISINRGLLCLGNVISALGDESKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNMEETLNTLRYADRARKIKNKPIVNTDPQAAELQRLKLQVQELQVLLLQAHGGTLPVLNSMEPSENLQSLMERNKNLEKENGKLSRELGEAAVQTAQFLEKIIMTEQQNEKLGSKMEELKQHAACKVNLQRLVETLEDQELKDNVEVIQNLQQVIVQLQDESSGIAGSIEAMDEEAASFPVPEEDSGEKRSSDGFTTNHALRQAQLSKELIELNKALVMKEALAKKMAQNDRQLEPIQSEYLNNIKHLESEVGVLQKEKEELILALHSAKKDNNQAKLSERRRKRLQELEGQMTELKKKLGEQSKLLKLRESTEKTVAKMNQEIQGMKMQRVQLMRQMKEDAEKFRTWKQQKTKEVIQLKEKDRKRQYELLKLERDFQKQANVLRRKTEEAASANKRLKEALQRQKEAMEKRKDSQSKGMEGAASRVKNWLANEVEVLVSTEEAQRHLNDLLEDRKILAQDIAQLKQKTDAGERIPTKIRRRTYTVAELENLEEEASVTKQIESLETEMELRSAQIADLQQKLLDADGEEEMVKRRWETISNIMEAKCALKYLITELVSSKVAGSKLESSVKQNRAHVADLQKNIFEERNQMAEMETEHQSQLMQLEQHHQEKILYLLSQLQQKQASVPVTIEELPAEEITEREKQLMERLKFQDEEIEKMKALCEKNQQLLQENDMYKQKLALLHVASGKKLHNILPAAEICSPDSPFDFIPPKPRGKRRTNAKSAAVILEDLLSESESEEESDDKNWEPGNNSKQSKKLTSKCSCKARCGNKMCGCRKTKQNCSDDCFCDPSKCRNRDNHMDEGKHEDQSLESENSKIDYPDVTAGGSFFTPPCVTPTKKVLREISDIGQVLSIKLQRKPSTASASASVMESQENQTSILTKKKKVLCNSNTSFFSGCSAITEDE
What is the function of this protein?
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity).  Required for mitotic chromosomal positioning and bipolar spindle stabilization.
What are the official names of this protein?
Chromosome-associated kinesin KIF4, Chromokinesin, Chromosome-associated kinesin KLP1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton. Note=Associated with mitotic chromosomes.
Protein: RLMN_RHIL3
Sequence: MSVMDEIVVTKPQARTSASLEKPSLIGMSREEMGAALREKGVAEKQIKMRVSQLWNWIYVRGVSDFDHMTNVAKDMREMLKQHFTIARPEIVEEQVSNDGTRKWLLRFPPRGAGRPVEIEAVYIPEEGRGTLCISSQVGCTLTCSFCHTGTQRLVRNLTAEEILSQLLLARDRLGDFPDREAPQGTIMPAEGRKVSNIVMMGMGEPLYNFDAVKQALLIATDGDGLSLSRRRVTLSTSGVVPEIFRTGEEIGVMLAISLHAVRDDLRDLLVPINKKYPLKELIEACRTYPGLSNARRITFEYVMLKDVNDSLEDAKGLIKLLKGVPAKINLIPFNPWPGTNYQCSDWEQIEKFADFINSAGYASPIRTPRGRDILAACGQLKSESERMRKTERLAFEAMMIANHGADD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_YEREN
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPIR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: NPC2_PANTR
Sequence: MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL
What is the function of this protein?
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.  Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1.  May bind and mobilize cholesterol that is associated with membranes.  NPC2 binds cholesterol with a 1:1 stoichiometry.  Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity).  The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
What are the official names of this protein?
NPC intracellular cholesterol transporter 2, EPI-1, Epididymal secretory protein E1, Niemann Pick type C2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes.
Protein: REX_ROSS1
Sequence: MDRMEEPPDVVIRRLPLYARSLRYLLQEGVESVSSQELGDRINVTAAQIRKDLSYFGEFGKQGIGYNVRKLLQQIEDILGLTREWPVAVVGIGHLGEAIARYEGFRQQGIRIAGLFDSNPSKIGTVIDGMTVQSIEEADRIIREQGIRLAIIAVPARSAQEVTDRLVMAGVRAILSYAPTVLQVPDGVWVRYIDPVAILHSMTYYLARDINSARHNSPES
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT25_MAGO7
Sequence: MQRLRARDLRAVDLYRTVKSNLDTKFSLPGMPPGREHRQVPPPWLQAMQKIPPSEILTRPIPIQHQKPNPKARKPKNIFRPQKIVYEEDELRKTFYRDHPWELARPRVILEIDGMDSHYCDWSQGLEQPSIPLSGESVVQRQLWLMHNEGMTKEKAYDLVRREFYALRQEEEVERRIAQEEARMVGAYFGKNRLQIGNELEDHEYERWKDWAATEMAKAEAERENAMPTFGGKAKDAEASIDDLMLEGSMDAILEEKKA
What are the official names of this protein?
37S ribosomal protein S25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYP_CARHZ
Sequence: MRLSQYFMPTLRENPAEAEVISHKLLLRAGFIRKSASGVYTYLPLAQRVLKKIMQIIREEMDRQGGQELMLPILQPAELWLETGRWHVYGPELFKLKDRHNRDFCLGPTHEEIITDLVRREVRSYKELPLLLYQIQNKYRDEKRPRFGLMRGREFIMKDLYSFDRDEEGLEISYRKMYEAYTNVFTRCGLKFRAVEADAGAIGGSTTHEFMVLANSGEAVVVYCPDDNCGYAANLEKAETKFTPEVIGTPAEIQKVATPNVKTVDEVAEFLKVEKKQILKSVLFKADDGYVLAVVRGDREVNEVKVKNQVDCLVLELASPQEVEEVLGAEYGSIGPVGVNIPVIADLEVKHVLNAVTGANETGYHLTGVNPERDFSPAVKYADIRLVEEGEPCPKCGKALVFARGIEVGQIFKLKDKYSRKMGAFYLDENGQQKPIIMGCYGIGVTRTMAAAVEQNHDEDGIIWPAAIAPFEVIVVPVSNKDEQQMKMAEEVYNLLLNAGFEVVIDDRDERPGVKFKDADLIGIPLRITVGKRTVSEGVYEVKIRRTREEKVFQKEELVDGLRQLLKTL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T111_SCHPO
Sequence: MSFDGLIVENENTKSGYNDGNDLTDLFKQNGTDMSVINSLLGDTNNPGMNESPKILDSSFENSNPQDGPNYEDFDFMGSIHKEFGNNINEMDDMEDVSDDNLPEEEQAVNYTGDKDDEDFGKLLAKEMGEEAAGQVLSGVGFSIPSGLVPPSEPSKTVSSTTEELQNEAQIRESIVKTFFPTFERGVLLNFSELFKPKPVKLAPPKKKTPKVCVPGRLTLEVDTDYAIIFNSKKSLPLKRNVVSPISTHTKKRRRTANTSQRNDGLDLNTVFTTNDWEKNIIYDESDVNKTNQSSFFIDKSLVDIDFAFDENIFDGDTGTSKVVLNLNDPKLLLQPQLPKKEDSQRSFADTHQRNSLAWKFNISNDPAYEMLKQNHQSKVRNTLSQLAIEHAAFAEKLTFPYYKTRLSKRAVRSYHRPTMSFKPNAAIVFSPLIVRKRSKDKHKSERELIPTTKEITMGDTTHAILVEFSEEHPAVLSNAGMASRIVNYYRKKNEQDESRPKLEVGESHVLDVQDRSPFWNFGSVEPGEITPTLYNKMIRAPLFKHEVPPTDFILIRNSSSYGSKYYLKNINHMFVSGQTFPVTDVPGPHSRKVTTASKNRLKMLVFRLIRRSPNGGLFIRQLSKHFSDQNEMQIRQRLKEFMEYKKKGDGPGYWKLKSNEVVPDEAGTRSMVSPETVCLLESMQVGVRQLEDAGYGKTMDEINDDEDEEQPAEQLLAPWITTRNFINATQGKAMLTLFGEGDPTGIGEGYSFIRTSMKGGFKPAGETADDKPEPQTKNAHAYNVAKQQRAYEEEINRIWNAQKRGLSINNLEELAKKYGINSIHDDYVESNEETTREETPSSDKVLRIVRLYRDKNGNLERKQETIHDPIVIHAYLKKRREIDEQSTALDAVVPTGDEAIDRRNRRRLEQELAKSQKNWERRRARHAAKEGINLNGEGRKPTTRKCSNCGQVGHMKTNKICPLFGRPEGGLATMLDKN
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Putative transcription initiation factor TFIID 111 kDa subunit, TAFII-111, TBP-associated factor 111 kDa.
What are the subcellular locations of this protein?
Nucleus.
Protein: AGNO_POVBO
Sequence: MALQWVWLCLRKSLRNNKLMMCRILIELLKILLDVLDSGDYADGPSDNPGTGIAKEEIVKCIDFLKMLEAGDDDIDKYGFPELLAAHFANCLAVCLKAARESDAMFCCSLEANSSDFN
What are the official names of this protein?
Bovine agnoprotein, Agno.
Protein: CAPSD_CMVP6
Sequence: MDKSESTSAGRNRRRRPRRGSRSASSSADANFRVLSQQLSRLNKTLAAGRPTINHPTFVGSERCRPGYTFTSITLKPPKIDRGSYYGKRLLLPDSVTEYDKKLVSRIQIRVNPLPKFDSTVWVTVRKVLASSDLSVAAISAMFADGASPVLVYQYAASGVQANNKLLYDLSAMRADIGDMRKYAILVYSKDDALETDELVLHVDIEHQRIPTSGVLPV
What is the function of this protein?
Capsid protein.  Probably binds RNA and plays a role in packaging (By similarity).
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: AGP11_ARATH
Sequence: MARLFVVVALLALAVGTVFAADAPSAAPTASPTKSPTKAPAAAPKSSAAAPKASSPVAEEPTPEDDYSAASPSDSAEAPTVSSPPAPTPEADGPSSDGPSSDGPAAAESPKSGATTNVKLSIAGTVAAAGFFIFSL
What is the function of this protein?
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
What are the official names of this protein?
Classical arabinogalactan protein 11.
What is the protein family that this protein belongs to?
Belongs to the classical AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: ASAH1_RAT
Sequence: MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
What is the function of this protein?
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity).  Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity).  For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity).  Has also an N-acylethanolamine hydrolase activity (By similarity).  By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity).  Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity).  By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
What are the official names of this protein?
Acid ceramidase, AC, ACDase, Acid CDase, Acylsphingosine deacylase, N-acylethanolamine hydrolase ASAH1, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.
Protein: COL2_CAEEL
Sequence: MDIDARIKAYKFVAYSAVTFSVVAVVSVFITLPMVYNYVNNVKKQIHTDVNFCKVSARDIWSEVHLIKDAPGNNTRVARQAYSTGGAGGGGGGGGGGCDGCCNPGPPGPGGSPGKPGKPGKPGAPGAPGNPGKGASAPCEPVTQPPCQPCPGGPPGPAGPAGPPGPPGPDGNPGSPAGPSGPGPAGPPGPAGPAGNDGAPGAPGGPGEPGASEQGGPGEPGPAGPPGPAGPAGNDGAPGTGGPGPAGPKGPPGAAGAPGADGNPGGPGTAGKPGGEGEKGICPKYCAIDGGVFFEDGTRRR
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
What are the official names of this protein?
Cuticle collagen 2.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: PROB_XYLFT
Sequence: MTGIPPPSRFPEQPIPPWRRAVLKVGSSLLAADGGGLSPRFALDLAHFVSANITAGRQLVIVSSGAVAAGRALIPPLPESGGALAARQALAALGQAQLIALWQRFFDRPVAQVLLTHDDLRNRRRYLNARATLRELLHLGTLPVVNENDTVSVDELKLGDNDNLAAIVAALIDAQALFIATDIDGLYTTDPRHHSDAQPLHEVRTLTPENLAMAGDSSSTVGTGGMRTKLEAALKAGAAGIDTYLFNGRSSDVVRGLAQHRLRGTRIHPTCTPIAARKYWLRHAPVEPGAILIDAGAAAALAQQGASLLPGGVLSAEGDFRRGDMIQIATRSPDHPSHPLARGLVQYSAADVRRIAGCHSRDIQTLLGYTYGDTIVHRDDLVLL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.