PharMolix/UniProtQA huggingface dataset:
Protein: IML1_CHAGB
Sequence: MPPPPRNSSSASLSATPGLAKGPNNNWPTHLRHFRRSSHDRSLEHAYSNSPGDTVSSNSTIRERPSSRLSSRLRTERRWTVTVNESLARDEVLLNLDLIGDDIQPGSLVAIDVVKADSEKPLQNSHPRHFQDRKDSATAGCVERRYICVAKDMPKELKARYASVEVYVAKHVADAFAMRKGTQVTLTPIDENNPALEASHVELCFKDQYLSRADMWRMAVGELAERTVYKGQMVLFMGTVKAQVTAVYVDGRKAQSAFFGRHTKPVFRSESARYVLFIQMAREMWDFDQDGSGEIMFNKVVNGFLPALFKKWAAMKVKHLVTIVLFARVEYDTGISTELASASAHHGYYTGVQASEDQRPYKDFYRVVVSEMGSGEWTRILHQLKREFNYFRKDISTYHQKAMEPTNSGEDSGEQEVLLNRIKAEASRAIHGNFLEAINMASSLYAHDYIDRDLTRTGVSVVVISPSPGVFEVEYDALRRTTEALACNGIGIDLICIPNIPLHSVPLFRYRNPRQPGQVQRKSKVDISQGSTPKQTTLTFGSYSSLAGSYSPNKRIEGSRNGEPAGPLSSQEEWVSAIPQWLHVSYWTGASEEELSYQGIALSVSDATQKLPSDEFPIRCRMYDLQMRSVMETNEIETKPLHTDPCYPLNAVLASQISKPHFDLDNDGNVIIPNARVPETLFDHVFGFQKFAPDRHRKPGEKSIWRQLQEYDDCRARLPSHRNANQTRRCRDHEETPRRQALEDTSPLGTSYTDRRPSTASQQTLPELSPYHRPTSQRLEVPPVNRKSMSAQSNKSEPKASSSPLKAPKFMRHISLGNRGFGIAAPKVATAEVSMESAGASKTLTPSRSSQDLRVTPSKPGQRPSSSRRLTGGTSTSALSPALSPFSFAPGPQFPTDSPTRPIVIRNQQLEPAAMLSGSSILATTLRPEPVGHDRDFRYSNAIRAEDAKKLYNSKLLAGAIPELPSTLSPKTALSPWLTVLNPSNPDTNDVDMAMLYSRWQHVFPRPQEMRIMKWKGLCSPAAVPLTSEYFPSRDQFEAQYERQPYNVSQDFDEELQEEPKSRDELLRELVSLRFSQGFQIVVGPAVAKAFGQKQVKVADIFSRNHMMEDGISIFMSVGNTIHQLSCVNGTEVEVNIFVRKPTDSFGPSFSSPTLYKPAIRTLLDGGYRTSEFDLVAPKAERNWNYIDAFIAGHNDELTEHLRFWRARFVLIPMTGRRSSMPGTETGDNEEEIRIEGIRKLAQMWQKHRYVPPNERRLQGSGSTRSKKDTNPLDIVYKTEDASVVIAAELETLPLLEGLDRKGQLVRNREPFSKKNINLAALAEAMQQPVENGGVRMQNRRWHFRLHYNCFIGSDMTSWLLDNFDDLEDREEAEALGKRLMVPDDKEKEGKKDSGLFVHVEKRHQFRDGQYFYQISNEFAKPHPPGWFNAKRGQGSMPSTPMGEQPPRDGRPSFSRPTSIHEEDSPESGETTPTAPQAPAGNKPKVVLSRVIKYDVDHRKRSYRPEMVELHYDRLHNPDNCYHLRIDWMNVTVQKLVEDVIENWAREAGQYGLRLVEVPIAEASAISEINPFRRPYKIKLAVPPPDQSPVTYYDPTSFTPQAHPGRQFYQKAILRRFDFVLDMEAASNFPSNVDVSYSWGRPDFRYTQYIHRSGSILAEITDDGHFLVLANRLYSSRAFAAREREMQKELRVERQEQGPAIGTPGLGSSIRVITPSSYTPYNIPTPLPPYDSSPVASPALRPVTTTTTATTTTAAPTSSSLLSPVVRPTLSAPGTTPGSTSASGTPGLTHTPNQGQPGKPPSTSATTTTACAGGGGPGSGWSTWTTREPEWIKDELENFCLDAAALEAFYRELRTAARATTSAGRCGHDAGFWCGWRWCWCWGWAREWD
What are the official names of this protein?
Vacuolar membrane-associated protein IML1.
What is the protein family that this protein belongs to?
Belongs to the IML1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: Y1348_ARCFU
Sequence: MAERERDREQHERLFKAASNPLRKKMAEKIGNRGITREELKKELGDVSDFEFKFNLDYLIAEGFVVEKDGKLYLTEDGVDLAYGG
What are the official names of this protein?
Uncharacterized protein AF_1348.
What is the protein family that this protein belongs to?
To A.fulgidus AF_0255 and AF_1363.
Protein: Y1121_FUSNN
Sequence: MKIGFNHEKYLEEQSKYILERVNNHDKLYIEFGGKLLADLHAKRVLPGFDENAKIKVLNKLKDKIEVIICVYAGDIERNKIRGDFGITYDMDVFRLIDDLRENDLKVNSVVITRYEDRPSTALFITRLERRGIKVYRHFATKGYPSDVDTIVSDEGYGKNAYIETTKPIVVVTAPGPGSGKLATCLSQLYHEYKRGKDVGYSKFETFPVWNVPLKHPLNIAYEAATVDLNDVNMIDPFHLEEYGEIAVNYNRDIEAFPLLKRIIEKITGKKSIYQSPTDMGVNRVGFGITDDEVVRKASEQEIIRRYFKTGCDYKKGNTDLETFKRSEFIMHSLGLKEEDRKVVTFARKKLELLNQEKDDKNDKQKTLSAIAFEMPDGKIITGKKSSLMDAPSAAILNSLKYLSNFDDELLLISPTILEPIIKLKEKTLKNRYIPLDCEEILIALSITAATNPMAEVALSKLSQLEGVQAHSTHILGRNDEQYLRKLGIDVTSDQVFPTENLYYNQ
What are the official names of this protein?
UPF0371 protein FN1121.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: KYNU_FLAJ1
Sequence: MTFQNTREFAKQLDAQDALNHYQEQFIFPKVNDKRVIYFTGNSLGLQPKRTKAYIDEVMNDWAELAVEGHFYAEKPWWDYQERFSEPLSKIVGALPSEVTVMNTLTVNLHLLMVSFYQPKGKRYKIICEEKAFPSDQYMFQSQVHFHGYKPEDAIVEIKRREGEHNIRLEDVLAKIEEVGDELALVLIGGVNYYTGQVFDIKTITAAGQKAGAKVGWDLAHAAGNIKLELHDWNVDFAAWCSYKYMNSGPGNASGVFVHERHHNDPDLPRFAGWWGHNKERRFKMEPNFDPVHGAGGWQISNLPVLSLAPYLASVEMFAEVGMDALIAKRDHITSYLEFILHEIDKEVESTFEIITPSNPEERASQLSVFLHGEGRSLFDYLMKNGVITDWREPNVIRLAPVPLYCSYEDMYDFGQILKKGILGK
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: CXG2_RAT
Sequence: MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRGPPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a role in myelination in central and peripheral nervous systems (By similarity).
What are the official names of this protein?
Gap junction gamma-2 protein, Connexin-47, Cx47, Gap junction alpha-12 protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Gamma-type subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: TAT_HV2SB
Sequence: METPLKAPESSLGSYNEPSSRTSEQDVATQELANQGEEILSQLYRPLETCNNKCFCKGCCFHCQLCFLNKGLGICYDRKGRRRRSPKKTKAHSSPASDKSISTRTGNSQTEKKQKKTLGTTLEADPGLGR
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus.
Protein: SMDC1_HUMAN
Sequence: MEQRLAEFRAARKRAGLAAQPPAASQGAQTPGEKAEAAATLKAAPGWLKRFLVWKPRPASARAQPGLVQEAAQPQGSTSETPWNTAIPLPSCWDQSFLTNITFLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGTRGPEEKKEGEKSAYSVFNPGCEAIQGTLTAEQLERELQLRPLAGR
What are the official names of this protein?
SAYSvFN domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass membrane protein.
Protein: ATPA_FLAJ1
Sequence: MAEIKPAEISAILRKQVEGFESGATLEEVGTVLQVGDGIARVYGLSNVQYGELVEFDNGMEGIVLNLEEDNVGVVLLGPSTGIKEGSTAKRTQRIASLKVGEQMVGRVVNTLGFPIDGKGPIGGDLYEMPLERKAPGVIFRQPVTEPLQTGVKAVDAMIPVGRGQRELVIGDRQTGKSTVCIDTILNQKEFYDAGKPVFCIYVAIGQKASTVAGIAKMLEEKGAMAYTVIVAANASDPAPMQVYAPFAGAAIGEYFRDSGRPALIVYDDLSKQAVAYREVSLLLRRPPGREAYPGDVFYLHSRLLERACKVIADDGIAKNMNDLPESIKPIVKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDGDLFNSGVRPAINVGISVSRVGGNAQIKSMKKVSGTLKLDQAQFRELEAFAKFGSDLDSVTLNVIEKGKRNVEILKQGLNDPYTVENQVAIIYAGSKNLLRNVPVEKVKEFEADFLAYLNSKHKDTLNALKAGKLDDSITDVIEKAAKEISAKYN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS4_NITOC
Sequence: MAKYTGPKLKQARREGTDLFLKSGVRPIDSKCKIEQVPGQHGAGARRARMSDYALQLREKQKLRRMYGVLERQFRRYYKEAARRKGSTGENLLKLLESRLDNVVYRMGFGSTRAEARQLINHKGVLVNGQGINIPSYQVRAEDVVAVREKAKRQDRIKFALELAQARAEAEWIEINAGKLEGVFKRVPERSELAPDIQENLVVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PTC71_DROYA
Sequence: MITHLKNWPRLLNRFVLQLKNARHSIHQFTHLAGRLQRPPKSGKSSRDPYLVTAVQGRSKKPRYPGERANQRFGEDSWFVSSTPLAEVMGVADGVGGWRDVGVDAGRFAKELMTCCSGQTQRSGFDGRSARNLLIAGFQELTHREQPVVGSSTACLATMHRRDCILYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPADRQDCYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLKILNGLKERGERDLLQGASQVVEKARELSLNATFQSPFAIKARQHNVPYSGGGKPDDITLILASVEVPRA
What are the official names of this protein?
Protein phosphatase PTC7 homolog fig, Fos intronic gene protein.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: CHLB_BAZTR
Sequence: KRLLKDLSIEINQVIPEGGSVENLRQLPKAWFNLVPYREVGLMTAKYLEKEFGMSYISITPMGVVDIANCIRQMEERINIMSPILLNRRVNYEPYINEQTRFI
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CB073_MOUSE
Sequence: MEGEEKQQQHKTEDDGIACVAERKVEIKNEKSPGKSTQHPKPCVDRRRVNYAKFIHTNARTYNEPVPYIDNKGPEKQRKWWFHNEAPKHVSQPSYDTKSVQRSDFQKPACPLVLPVKHSRMQKPSCGIVPLTSLDVSGEHENNFVEYISFIHQYDARRTPNEPIKGKKHGTFVQREIKLGAMPIVPKAPEVLLNTLESGSSEQPQKTDKGNSSGDKVTSPGLCQQNSQELLET
What are the official names of this protein?
Uncharacterized protein C2orf73 homolog.
Protein: EPHB2_COTJA
Sequence: MGPLWFCCLPLALLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKYIRRRGAHRIHVEMKFSVRDCSSIPNVPGSCKETFNLYYYESDFDSATKTFPNWMENPWMKVDTIAADERFSQVDLGGRVMKINTEVRSFGPVSKNGFYLAFQDYWGCMSLIAVRVFYRKCPRVIQNGADFQETLSGAESTSLVASRGTCINKAEEVDVPIKQHCNGDGEWLVPIGRCMCRPGYESVANGTVCRGCPSGTFKASQGDEGCVHCPINSRTTSEGATNCVCRNGYYRADADPVDMPCTTIPSAPQSVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQFAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKNLSELNSTAVKSPTNTVTVQNLKAGTIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSVQEKLPLIIGSSAAGLVFLIAVVVIIIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNTLVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGVNLPLLDRTIPDYTSFNTVDEWLDAIKMSQYKESYASAGFTTFDIVSQMTVEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Functions in axon guidance during development.  In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses (By similarity).
What are the official names of this protein?
Ephrin type-B receptor 2, EPH-like kinase 5, EK5, qEK5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
Protein: Y3466_MYCTU
Sequence: MGSGSRERIVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL
What are the official names of this protein?
Uncharacterized protein Rv3466.
What is the protein family that this protein belongs to?
Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
Protein: QKIB_XENLA
Sequence: MVGETETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFTHLERLLDEEISRVRKDMYNDTLNGSNNEKRTNELPDGIGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANLKSPALAFSLAATAQAPRIITGPAPVLPPAALRTPTPAGPTLMPLIRQIQTATVMPNGTPHPTATLMSQAPEAGLIYTPYEYPYTLAPATSILEYPIETSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
What is the function of this protein?
RNA-binding protein that plays a central role in myelinization.  Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence.  Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation.  Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation.  Participates in mRNA transport by regulating the nuclear export of MBP mRNA.  Also involved in regulation of mRNA splicing of some pre-mRNA.  Acts as a translational repressor (By similarity).
What are the official names of this protein?
KH domain-containing RNA-binding protein qki.L, Protein quaking-B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: NADE_METKA
Sequence: MAKYEPVIPELEVNPEGEVSKIAEFLRGKFEEAGREIAVVGLSGGVDSSTTLGLAVEALGRENVVALILPERDTPEEDVEDAVEAAERFGVEYHVHDITEVLRAFGTGSYVPCHPFSRKSDANLKPRVRMCVLYYFANELDGLVLGTGNRTEWLTGYFTLHGDGACDVAPIRHLYKTQVYVIAEHLGVPERIVEEKEPSARLWPGQTDEGELGIDYPTLDALLYALVDEGLGPRKAVDWLGERGVEATEEDAEKVLDLVRSSSFKRRPAPGLDLPEPEDPAMSG
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: Y956_HAEIN
Sequence: MIIPWQELEAETLDNIVESVILREGTDYGIEELSLNQKKQLLLTQIRNGIALIVWSELHESIDIKNKTEFLKQECKEQECQMN
What are the official names of this protein?
UPF0270 protein HI_0956.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: ARND_SALA4
Sequence: MTKVGLRIDVDTLRGTREGVPRLLATLHRHGVQASFFFSVGPDNMGRHLWRLIRPRFLWKMLRSNAASLYGWDILLAGTAWPGKNIGNANAGIIRETATYHETGLHAWDHHAWQTHSGHWSIRQLEEDIARGITALEAIIGKPVTCSAAAGWRADGRVVRAKEPFNLRYNSDCRGTTLFRPLLMPGQTGTPQIPVTLPTWDEVIGPAVQAQSFNTWIISRMLQNKGTPVYTIHAEVEGIVHQPLFEDLLVRARDAGITFCPLGELLPTSPESLPLGQIVRGHIPGREGWLGCQQAASAS
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: PTN_RAT
Sequence: MSSQQYQQQRRKFAAAFLALIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD
What is the function of this protein?
Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16814777, PubMed:27671118, PubMed:9817766).  Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity).  Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:27671118, PubMed:9817766).  Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity).  Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:16814777).  Through PTPRZ1 binding, regulates endothelial cell migration and controls oligodendrocyte precursor cell differentiation (By similarity).  Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity).  In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity).  Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (PubMed:27671118).  Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (PubMed:9817766).  Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity).  Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity).  Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity).  In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity).
What are the official names of this protein?
Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neutrophic factor, HBNF, Osteoblast-specific factor 1, OSF-1.
What is the protein family that this protein belongs to?
Belongs to the pleiotrophin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DHAS_HELPY
Sequence: MKTYNVAIVGASGAVGQELIKGLENSFFPIKKFVPLASTRSAGKKIKAFNKDYEILETTHEVFEREKIDIAFFSAGGSVSEEFATSASKTALVVDNTSFFRLNKDVPLVVPEINAKEIFNAPLNIIANPNCSTIQMTQILNPLHLHFKIKSVIVSTYQAVSGAGNKGIESLKNELKTALECLEKDPTIDLNQVLQAGAFAYPIAFNAIAHIDTFKENGYTKEELKMLHETHKIMGVDFPISATCVRVPVLRSHSESLSIAFEKEFDLKEVYEVLKNAPSVAVCDDPSHNLYPTPLKASHTDSVFIGRLRKDLFDKKTLHGFCVADQLRVGAATNALKIALHYIKNA
What is the function of this protein?
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
What are the official names of this protein?
Aspartate-semialdehyde dehydrogenase, ASA dehydrogenase, ASADH, Aspartate-beta-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: HISM_SHIFL
Sequence: MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSSTH
What is the function of this protein?
Part of the histidine permease ABC transporter.  Also part of a lysine/arginine/ornithine transporter.  Probably responsible for the translocation of the substrate across the membrane.  Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).
What are the official names of this protein?
Histidine transport system permease protein HisM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: XPOT_KLULA
Sequence: MSHIQQAVDIANSSTAGNDLKKQALDFLQQLKSSEDAVQVFSQYLQDPVASDVGRFFALQVLSEQALELPANHEKLYALQQSALQFLRTQLENSSSDGARVSGVGQGSKGVKSTPPEFVRNKVAELFAHLFYNMYGEVNNNMWSSFFVDLIQLVGIASLRDSKSTGVEFNAIGLDLFFRICASINTEIGDQAFVRSKEVQLKNNELKDYMRVQDVELLSNIWFSALLNCQQLPVLASLVLQCVGSYISWIDINLIVQQSYIGTIYEYLKFPQTKLACGQCLCEIISKKMKPADKLQLLSMLNLTDRVVATGSAEDLDVLEQMAKLTNGVALELSMVMDQCNDSQELQSVSSAADEQIINVVSPLVLKFMAHEYDSVTQQCFSFVTNYLAVMKKLFALGGKPGSAVAVNSKRIPIDPAHLNFLKSLGTVCVLKMKIDDSCDSIDDNEEIDEFVENIRSKLKTFQDSIAVINPELYFDIISDNIEQSITEQQDWRVLELAIYQLHNFAESIRNNLFGVNKTEISTSKPAQLMEKYMTTLLNHPTLFQMNNPLVQISFFELVVRHNNFIQVENKDLTLLNIFCTPFSMFSGNERVRLRTWYLFTRLIKTSKPKLSTDFLSMLLSKISPLLSIKASPLAQELDTIFDSQLYLFEGTGVLIGANVNNEYEILDGVLTPLFADLEQCISAQVKNPQVVLQTHHILMAIGTVARGVHSGLVPDNQVNNAKVSERVICKSLIEKFSNIAEVILVTFSYFNKFETIRDAARFSFSRLIPILNNQIIPFASRLISIFLNSDLKPLEMGDFIGFLGQMIHMFKDDDNCYQLFNNLFTPVVEKVFTLETQLEQESSTSSESKSSNGKNVIVTDSFREKINLKKSYYGLLATFVSNNCTSLLLTESNKNILPRVLTDLLSYTAEEIHETSTMKLSINVLVNFINFFGTGICTDPKDRNAINVNKLDGLNEFFITTSIPLLFEIPFKPEYEFNIQDGGCRVIACDLSRLLKALYNINNSSTNNNINENACVKYLTEIYFPQIQFPQSLVVEFINALGTLDAKQFEKYFVQFITNMKQ
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: MVP_TMOB
Sequence: MSKAIVKIDEFIKLSKSEEVLPSAFTRMKSVRVSTVDKIMAKENDNISEVDLLKGVKLVKNGYVCLVGLVVSGEWNLPDNCRGGVSICLIDKRMQRHNEATLGSYTTKASKKNFSFKLIPNYSITSQDAERRPWEVMVNIRGVAMSEGWCPLSLEFVSVCIVHKNNVRKGLREKVTAVSEDDAIELTEEVVDEFIEAVPMARRLQNLRKPKYNKEKENKNLNNKNSIGVSKPVGLERNKVRSVVRKGVRSDSSLGVTDMSQDGSSSEISSDSFI
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Forms a ribonucleoprotein complex with viral RNA.  Binds microtubules and modulates microtubule stability.  Can bind double-stranded DNA.
What are the official names of this protein?
Movement protein, 30 kDa protein, Cell-to-cell transport protein.
What is the protein family that this protein belongs to?
Belongs to the tobamovirus movement protein family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton. Host cell junction, host plasmodesma.
Protein: PLSY_BURPS
Sequence: MQILLATVAAYLIGSVSFAVVVSAAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWLAVWLVKRFGIGGEIGVALAAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPIFDVFLFGTRDNPVAWAVLAMSVLLIWRHRSNISKLLAGEESRIGQKKKTGA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.