PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_STRR6
Sequence: MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELETAYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHPTYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDITVRGECYMPRASFDQVNQARQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQEASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVVIKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIPTNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFAANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGSKASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFAAEGSEILLRELKETGVNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVVVGADAGSKLQKAQELGIQVRDEAWLESL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PURA_BIFAA
Sequence: MPGIVLIGAQWGDEGKGKATDLIGTKVDYVARFNGGNNAGHTVVVGDESYALHLLPSGIISPNTTPVIGNGVVVDPEVLFQEIDGLESRGVDCSRLLVSESAHIIAPYHRVLDKVTERFLGKHKIGTTGRGIGPAYADKINRVGIRVHDLFNAEHLHDKVEASLHQKNQMLVKLYNRRPIDVDETTDELLKLGERLKPYVANTSLVLNKALDEGKTVLFEGGQATMLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKITRVVGVSKAYVTRVGEGPFPTELFGEEGEWLRAQGHEYGVTTGRPRRCGWFDAVVNRYAAQVNGLTDIVLTKLDVLTGLKEIPLCVAYDVNGERRDDMPTDQAEFAAAKPIYESMPGWDEDISQVHDFNDLPKTCQDYVKRLEELSGCRISVIGTGPQRDHIIQINSLID
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_YERPY
Sequence: MKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADALMVRSVTKVNEALLHGTSIGFVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRALEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASLLPVPEFSHLRLNGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLRKHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_SALEP
Sequence: MSDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQTGETLLIIADDPATTRDIPGFCTFMEHDLLAQETEGLPYRYLLRKAH
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_NITMU
Sequence: MKALLDLFKQVTQKEEFDSIKIGLASPEKIRSWSYGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTLSKVRRERMGHIELASPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVTDPGLTPLQRCQLLTDDDYRAKTEEYGDDFRASMGAEGIRDLLNTLNIRVEIDDLRREMGTTGSETKMKKISKRLKVLEAFSKSGIKPEWMILAVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKKMALELFKPFIFNKLEIMGIASTIKAAKREVENESPIVWDILEDVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMECRTLMMSTNNVLSPANGEPIIVPSQDIVLGLYYTTREKVNARGEGMYFANISEVSRAYENRVIELNARIFVRIREYELADGERREKITRYETTVGRALLSEILPAGLPFPLINKVLKKKEISKLINASFRRCGLRETVIFADKLMYAGFSYATRAGISICLDDMLTPAQKDAIISASEKEVQEIELQYTSGLVTQGERYNKVVDIWGRAGDQVAKAMMDQLGVEPIIDPETGTAKTGESGKPLIQESFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVTQEDCGTSNGVVMKALVEGGEVIEALRERILGRVVANDIINPEHQAVIYPAGMLLDENAVDTIEMLGIDEVKVRTPLTCETRYGLCAKCYGRDLGRGTPVNVGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRTAVASQVESKSNGIVRYSPTMRYVTNARNELIAISRSGEVVIQDDNGRERERHKAPYGATLLIRDGEVVKAGQVLAAWDPHTRPIITEYSGKVRFENVEEGVTVAKQIDEVTGLSTLVVIDPKRRGVVQTKGLRPVVKLLDEEGKEVRLAGSNLPVHITFQVGSIITVRDGQQVSVGEVLARIPQESSKTRDITGGLPRVAELFEARSPKDAGVLAEVTGIVSFGKDTKGKQRLVITDLDGVSHEYLIPKDKHVTAHDGQVVNKGESIVDGPADPHDILRLLGVEALARYITDEVQDVYRLQGVKINDKHIEVIVRQMLRRVQIVDSGDTRFIPGEQVERAEMLAENEQVELEGKRPATYEYMLLGITKASLSTDSFISAASFQETTRVLTEAAIMGKKDDLRGLKENVIVGRLIPAGTGLTFHNTRKRQRLMLDTGEAPPLSEEETGEIRNSGYAV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ZN37A_HUMAN
Sequence: MITSQGSVSFRDVTVGFTQEEWQHLDPAQRTLYRDVMLENYSHLVSVGYCIPKPEVILKLEKGEEPWILEEKFPSQSHLELINTSRNYSIMKFNEFNKGGKCFCDEKHEIIHSEEEPSEYNKNGNSFWLNEDLIWHQKIKNWEQSFEYNECGKAFPENSLFLVHKRGYTGQKTCKYTEHGKTCDMSFFITHQQTHPRENHYGNECGENIFEESILLEHQSVYPFSQKLNLTPIQRTHSINNIIEYNECGTFFSEKLVLHLQQRTHTGEKPYECHECGKTFTQKSAHTRHQRTHTGGKPYECHECGKTFYKNSDLIKHQRIHTGERPYGCHECGKSFSEKSTLTQHQRTHTGEKPYECHECGKTFSFKSVLTVHQKTHTGEKPYECYACGKAFLRKSDLIKHQRIHTGEKPYECNECGKSFSEKSTLTKHLRTHTGEKPYECIQCGKFFCYYSGFTEHLRRHTGEKPFGCNECGKTFRQKSALIVHQRTHIRQKPYGCNQCGKSFCVKSKLIAHHRTHTGEKPYECNVCGKSFYVKSKLTVHQRIHLGRNPINVVNEGNYSG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 37A, Zinc finger protein KOX21.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL4_SYNE7
Sequence: MVDYVIQDWQGQTAGNITVELRVAKEESAAAIVHRALIRQLANARQGTHASKTRSEVRGGGRKPWKQKGTGRARAGSIRSPLWRGGGVIFGPKPRDYSVKMNRKERRLALRTALISRSADLVVVQEFADQISRPKTRDVAEALTRWGVEPGVKVLLITADRDQNVELSVRNLPNVKLITATNLNIFDLLNADRIVSTSAALEKIQEVYGG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: IF4A1_ARATH
Sequence: MAGSAPEGTQFDARQFDQKLNEVLEGQDEFFTSYDDVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERMLFDIQKFYNVVVEELPSNVADLL
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
What are the official names of this protein?
Eukaryotic initiation factor 4A-1, eIF-4A-1, ATP-dependent RNA helicase eIF4A-1, DEAD-box ATP-dependent RNA helicase 4, AtRH04.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1B_OXYTA
Sequence: FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSLADENAIRQQNQ
What is the function of this protein?
Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores.  Has antimicrobial activity, hemolytic activity and insecticidal activity.
What are the official names of this protein?
M-oxotoxin-Ot1b, M-OXTX-Ot1b, Oxyopinin-1b.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 02 (oxyopinin-2) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey.
Protein: US9_EHV1K
Sequence: MEKAEAAAVVIPLSVSNPSYRGSGMSDQEVSEEQSAGDAWVSAAMAAAEAVAAAATSTGIDNTNDYTYTAASENGDPGFTLGDNTYGPNGAASGCPSPPSPEVVGLEMVVVSSLAPEIAAAVPADTISASAAAPATRVDDGNAPLLGPGQAQDYDSESGCYYSESDNETASMFIRRVGRRQARRHRRRRVALTVAGVILVVVLCAISGIVGAFLARVFP
What is the function of this protein?
Essential for the anterograde spread of the infection throughout the host nervous system.  Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope protein US9 homolog, Envelope protein 76, ORF76 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae envelope protein US9 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein.
Protein: GP1D_CHLTH
Sequence: MKTRSEIENRMQDIEYALLGKALIFEDSTEYILRQLANYEFKCSHHKNIFIVFKYLKDNGLPITVDSAWEELLRRRIKDMDKSYLGLMLHDALSNDKLRSVSHTVFLDDLSVCSAEENLSNFIFRSFNEYNENPLRRSPFLLLERIKGRLDSAIAKTFSIRSARGRSIYDIFSQSEIGVLARIKKRRATFSENQNSFFDAFPTGYKDIDDKGVILAKGNFVIIAARPSIGKTALAIDMAINLAVTQQRRVGFLSLEMSAGQIVERIIANLTGISGEKLQRGDLSKEELFRVEEAGETVRESHFYICSDSQYKLNLIANQIRLLRKEDRVDVIFIDYLQLINSSVGENRQNEIADISRTLRGLASELNIPIVCLSQLSRKVEDRANKVPMLSDLRDSGQIEQDADVILFINRKESSSNCEITVGKNRHGSVFSSVLHFDPKISKFSAIKKVW
What is the function of this protein?
Required for growth within mammalian cells.
What are the official names of this protein?
Probable plasmid replicative DNA helicase, DnaB-like protein, Protein P-3, Virulence plasmid protein pGP1-D.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: MRAZ_HAEI8
Sequence: MFRGATAVNLDSKGRVAIPTRYRAEILEKNQGQMVCTVDIRQSCLLLYPLDEWEKIEQKLLALSNFDPTQRRLQRVMLGHATECEMDAQGRILLSGPLRQHAKLEKGLMLVGQLNKFEIWSDVEWHTQIAEDIEIGSSTDFAADALNDFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MIAB_NEIG1
Sequence: MKKVFIRTFGCQMNEYDSEKMLSVLAEEHGGIEQVTQADEADIILFNTCSVREKAQEKVFSDLGRVRPLKEKNPGLIIGVAGCVASQEGENIIKRAPYVDVVFGPQTLHRLPKMIVDKETSGLSQVDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCSFCVVPYTRGEEFSRPLNDVLTEIANLAQQGVKEINLLGQNVNAYRGEMDDGEICDFATLLRIVHEIPGIERMRFTTSHPREFTDSIIECYRDLPKLVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAIRPDLCLSSDFIVGFPGETEREFEQTLKLVKDIAFDLSFVFIYSPRPGTPAANLPDDTPHEEKVRRLEALNEVIEAETARINQTMIGTVQRCLVEGISKKDPDQLQARTVNNRVVNFTGTPDMINQMIDLEITEAYTFSLRGKIVEA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_STAAS
Sequence: MANYDVLKLDGTKSGSIELSDAVFGIEPNNSVLFEAINLQRASLRQGTHAVKNRSAVSGGGRKPWKQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYAYKMPKKMRRLALRSALSFKAQENGLTVVDAFNFEAPKTKEFKNVLSTLEQPKKVLVVTENEDVNVELSARNIPGVQVTTAQGLNVLDITNADSLVITEAAAKKVEEVLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: FLIO_SALTI
Sequence: MMKTEATVSQPTAPAGSPLMQVSGALIGIIALILAAAWVIKRMGFAPKGNSVRGLKVSASASLGPRERVVIVEVENARLVLGVTASQINLLHTLPPAENDTEAPVAPPADFQNMMKSLLKRSGRS
What are the official names of this protein?
Flagellar protein FliO.
What is the protein family that this protein belongs to?
Belongs to the FliO/MopB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Bacterial flagellum basal body.
Protein: DAP4_PSEMX
Sequence: MRLALFALFALMTVATALPAHAEKLTLEAITGSAPLSGPTLTKPQIAPDGSRVTFLRGKDRDRNRLDLWEYDIASGQTRLLVDSSVVLPGEEVLSDEEKARRERQRIAALSGIVDYQWSPDGKALLFPLGGELYFYDLTKSGRDAVRKLTNGGGFATDPKISPKGGFVSFIRDRNLWAIDLASGKEVQLTRDGSDTIGNGVAEFVADEEMDRHTGYWWAPDDAAIAFARIDETPVPVQKRYEVYPDRTEVVEQRYPAAGDHNVRVQLGVIAPKTGARPRWIDLGKDPDIYLARVDWRDPQRLTFQRQSRDQKKIELIETTLTNGTQRTLVTETSTTWVPLHNDLRFLKDGRFLWSSERSGFEHLYVASEDGSTLTALTQGEWVVDSLLAIDEAAGLAYVSGTRDGATEAHVYAVPLSGGEPRRLTQAPGMHAATFARNASVFVDSWSSDTTLPQIELFKADGTKLATLLVNDVSDATHPYAKYRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWPGRSDSFFNQYLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGIEWLKSQAFVDPARIGVYGWSNGGYMTLMLLAKHDEAYACGVAGAPVTDWALYDTHYTERYMDLPKANEAGYREASVFTHVDGIGAGKLLLIHGMADDNVLFTNSTKLMSELQKRGTPFELMTYPGAKHGLRGSDLLHRYRLTEDFFARCLKP
What is the function of this protein?
Catalyzes the sequential release of Tyr-Pro, Phe-Pro and Gly-Pro from the N-terminus of peptides and proteins.  Is able to cleaves bioactive peptide beta-casomorphin.
What are the official names of this protein?
Dipeptidyl aminopeptidase 4, Dipeptidyl aminopeptidase IV, DAP IV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
[Isoform 2]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 1]: Periplasm.
Protein: E2FF_ARATH
Sequence: MSSAIVVSQDAESLGLQIYSRKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGQLGVERRRIYDVVNILESIGIVARRGKNQYSWKGFGEIPRSLDELKEEGMRERLGYSSSNNSDKVSNGCEREEPLTLTPDDQENSSSSKMDQKKEKSLWLLAQNFVKMFLCSDDDLITLDSAAKALLSDSPDSVHMRTKVRRLYDIANVFASMNLIEKTHIPVTRKPAYRWLGSKSIAERGLSLFNSGEPKRVFGTEITNLRAKRNKTYCSSIRKQIGYKKHDEENTEQESKPAASKYVFGPFSPIGASKTNNDKVGKGRLLEIEALASTYQPQYCNQEITGLLGHFTEAWKKWYAEVDRNK
What is the function of this protein?
Inhibitor of E2F-dependent activation of gene expression.  Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers.  Does not bind retinoblastoma-related proteins.  Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels.  Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells.
What are the official names of this protein?
E2F transcription factor-like E2FF, DP-E2F-like protein 3, E2F-like repressor E2L2.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CAPSD_BPT5
Sequence: MTIDINKLKEELGLGDLAKSLEGLTAAQKAQEAERMRKEQEEKELARMNDLVSKAVGEDRKRLEEALELVKSLDEKSKKSNELFAQTVEKQQETIVGLQDEIKSLLTAREGRSFVGDSVAKALYGTQENFEDEVEKLVLLSYVMEKGVFETEHGQRHLKAVNQSSSVEVSSESYETIFSQRIIRDLQKELVVGALFEELPMSSKILTMLVEPDAGKATWVAASTYGTDTTTGEEVKGALKEIHFSTYKLAAKSFITDETEEDAIFSLLPLLRKRLIEAHAVSIEEAFMTGDGSGKPKGLLTLASEDSAKVVTEAKADGSVLVTAKTISKLRRKLGRHGLKLSKLVLIVSMDAYYDLLEDEEWQDVAQVGNDSVKLQGQVGRIYGLPVVVSEYFPAKANSAEFAVIVYKDNFVMPRQRAVTVERERQAGKQRDAYYVTQRVNLQRYFANGVVSGTYAAS
What is the function of this protein?
Major capsid protein that self-associates to form 120 hexamers and 11 pentamers, building the T=13 icosahedral capsid which about 860 Angstroms in diameter.  Responsible for its self-assembly into a procapsid.  The phage does not need to encode a separate scaffolfing protein because its capsid protein contains the delta domain that carries that function.  The capsid gains its final stability through the reorganization of the subunits that takes place upon expansion.  DNA encapsidation through the portal triggers capsid expansion and the binding of the decoration protein to the capsid exterior.  Might play a role in counteracting the host Pycsar defense system that is mediated by pyrimidine cyclases and leads to abortive infection.
What are the official names of this protein?
Major capsid protein, Capsid protein pb8, Major head protein.
What is the protein family that this protein belongs to?
Belongs to the HK97 phage major capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Forms the icosahedral capsid shell which contains 775 major capsid proteins.
Protein: CAPSD_PAVC7
Sequence: MAPPAKRARRGLVPPGYKYLGPGKSLDQGEPTNPSDAAAKEHDEAYAAYLRSGKNPYLYFSPADQRFIDQTKDAKDWGGKIGHYFFRAKKAIAPVLTDTPDHPSTSRPTKPTKRSKPPPHIFINLAKKKKAGAGQVKRDNLAPMSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVEITANSSRLVHLNMPESEKDRRVVVNNMDKTAVNGNMALDDIHAQIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVSFEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRYYFQWDRTLIPSHTGTSGTPTNIYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQTNRALGLPPFLNSLPQSEGATNFGDIGVPQDKKRGVTQMGNTNYITEATIMRPAEVGYSAPYYSFEASTQGPFKTPIAAGRGGAQTDENQAADGNPRYAFGRQHGKKTTTTGETPERFTYIAHQDTGRYPEGDWIQNINFNLPVTNDNVLLPIDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRLHVNAPFVCQNNCPGQLFVKLAPNLTNEYDPDASANMSRIVTYSDFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFNYVPSNIGGMKIVYEKSQLAPRKLY
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1.  The capsid encapsulates the genomic ssDNA.  Capsid proteins are responsible for the attachment to host cell receptor TFRC.  This attachment induces virion internalization predominantly through clathrin-endocytosis.  Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s).  VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell.  Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein.  Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).
What are the official names of this protein?
Capsid protein VP1, Coat protein VP1.
What is the protein family that this protein belongs to?
Belongs to the parvoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: Y1256_CLOTE
Sequence: MNSYNKQIGNIGEAVAENYLIQNGYIILDRNFSCRVGEIDIIGKDGDIISFLEVKSRYGNLYGSPGESVNFAKQYKIYKTAQLYILKKKLNRFYFRFDVIEIIFNNYNDDYSIRLIKDAFQL
What are the official names of this protein?
UPF0102 protein CTC_01256.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: DPO3A_TREPA
Sequence: MARMSFVHLHVHSNYSLLDGASSLQRLVRTAKSLGQEALALTDHGNMFGALHFQKVCSAEGIKAIIGCELYVAPESRFDRSEHTIGRRYYHLIVLAKNETGYRNLMVLSSKAYIEGMYYKPRVDDELLAQHAEGLICLSSCLAGQLPYLLLQGRKREAEEHARKYRALFGVDNYFIEVQDHGLDEEKKVAPLLIELACRLGIPLVVTNDVHYAEQEDSVAQDILLCIGTKKNRSDPNRLKFKTDEFYLKSSEKMAQLFPHYPEMVLNTVRIAQRCNVRIPQPGPLLPLYQIPHEFSSKEHYIRHLVHRGLYDRYAVVSEEIKARADYELDVIVRMDFVGYFLIVWDFITWAKEHDIPVGPGRGSGASSIVAYALKITDIDPLRYKLLFERFMNPERISMPDFDIDFCFERRQEVIEYVRARYGNDNVGQIITFGTLKPKAAIRDVGRVLDIPLSEVLMITKLMPDDPKLTFKKAYESEQLAQMKQEPRYAELFQIAEKLEDTNRNTSLHAAGIVIGKTALTDYVPLYKDSKTGKISTQFGMDLIEDCGLVKMDFLGLKTLTLIQRTQNLVRRKGGKYTTFSISDISDQDPTTFSMLAEGKSAAVFQFESRGMQGILKRAKPSKMEDLIALNALYRPGPMAFIDQYIESKRDPGKIKYPDPCLEDILSETYGVIVYQEQVMQVAQRIAGFSLGEADILRRAMGKKKLAVMQEKKKEFAERAEKQGFDKKHAENIFEILIPFAGYGFNKSHATAYSVVAYQTAFLKANFPAEFMAANLSNEINSAEKLPLYMAEAEKMGLSIQKPDVNASEPYFSVCEGCIVYGLLGIKGLGEQVAFDVFDERIRNGPYTSFVEVLDRVPATSLNKKNAEIMIKAGCFDRFGVTRASLTAHLDDAMKYVARKKAVTSSRQASLFDETDLGECSEYTFPVMEEWSQRERLRIEKELMGYYISGHPLDEYRSVIGEKATLDLGHIENARSENKYLIVGVLNAIHPYTTKSGKNMAFGSFEDLHGSVDIVVFPVLWEEHRAQFLPETIMGLVGTVDFSKETPAFLVDSVIDLEQLRFAQVKTILAGSEHRRVSSGEKTPLQKRGVSQEVHIEVSSHVRAHAQFKSLYEILSAHTGGSGEVFLHMHVDDRTYVVYVPSCKVSATEVFAQQLKGNESFVQILKECVQ
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNHA1_STAAU
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLSVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in Na(+) and/or Li(+) excretion.  Na(+)/H(+) antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic.  Does not transport K(+), Ca(2+) or Mg(2+).
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1, Mrp complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.