PharMolix/UniProtQA huggingface dataset:
Protein: RL21_STAAN
Sequence: MFAIIETGGKQIKVEEGQEIFVEKLDVNEGDTFTFDKVLFVGGDSVKVGAPTVEGATVTATVNKQGRGKKITVFTYKRRKNSKRKKGHRQPYTKLTIDKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: PYRF_STRA3
Sequence: MLEKCPIIALDFSDLASVTTFLEHFPKEELLFVKIGMELYYSEGPSIIRYIKSLGHRIFLDLKLHDIPNTVRSSMSVLAKLGIDMTNVHAAGGVEMMKAAREGLGEGPILLAVTQLTSTSQEQMQVDQHINLSVVDSVCHYAQKAQEAGLDGVVASAQEVKQIKKQTNEHFICLTPGIRPPQTNQLDDQKRTMTPEQARIVGADYIVVGRPITKAENPYQAYLEIKEEWNRIK
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RBM18_HUMAN
Sequence: MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPTQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR
What are the official names of this protein?
Probable RNA-binding protein 18, RNA-binding motif protein 18.
Protein: AROA_HISS2
Sequence: MEKLTLSPISRIDGEINLPGSKSLSNRALLLAALAKGTTQVTNLLDSDDIRYMLNALKALGVNYQLSDDKTVCVVEGIGGAFQWQNGLSLFLGNAGTAMRPLAAALCLKGDTESEVILTGEPRMKERPIKHLVDALRQTGANIQYLENDGYPPLAIRNQGIFGGKVQIDGSISSQFLTALLMAAPLGEGDMEIEILGELVSKPYIDITLAMMKDFGINVEHYNYQRFLIKGKQYYISPQTYLVEGDASSASYFLAAAAIKGKVKVTGIGRNSIQGDRLFADVLAQMGAKVTWGEDFIQVEKSELKGIDMDMNHIPDAAMTIAITALFAQGETVIRNIYNWRVKETDRLTAIATELRKLGAEVEEGEDFIRIQPLALDKFKHAEIATYNDHRIAMCFSLIALSDTSVTILDPACTAKTFPTYFSEFEKISKNQ
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_METLZ
Sequence: MTEISDILLRTILDSRGNPTVEAEISTISGGFGRACAPSGASTGIYEAKVRPCDEAVADAYINLIPKLIELDSADQRGFDDTLHEVDGTSDLSGIGANIAVALSLANAKAAASTLNMELYQYLGGAFISQTPLPLGNVIGGGAHAVDATDIQEFLIVPTGASTAAEAVFTNALVHKRIKEILIARGKGCGKGDEGGWAPHIADLEAFEIVNEATTKVFDETGIEVRMGLDVAASEMWDAASGRYVYKNAKRTTEEQIAYIADLTEKYNLIYVEDPIQEEDFEGFARITEEVSGRDTLICGDDLFVTNASRLEEGIRNDACNCVLIKPNQIGTLTDTFETISLAHDYGYETVMSHRSGETTDNTIAHLATAFGCCFMKSGVVGGERIAKLNELIRIEEHF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: TXH4_CYRSC
Sequence: MVNMKASMFLALAGLVLLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQIGK
What is the function of this protein?
This lethal neurotoxin (without cyclization at position 53) inhibits neuronal voltage-gated sodium channel Nav1. 2/SCN2A (IC(50)=10-150 nM), rNav1. 3/SCN3A (IC(50)=338 nM), Nav1. 6/SCN8A (IC(50)=117 nM), and hNav1. 7/SCN9A (IC(50)=9. 6-33 nM) (PubMed:18628201, PubMed:20855463, PubMed:25658507, PubMed:29703751, PubMed:31234412, PubMed:23760503).  It inhibits activation of sodium channel by trapping the voltage sensor of domain II (DIIS4) in the closed configuration (PubMed:18628201, PubMed:23760503).  The toxin neither shifts the Nav1. 7/SCN9A activation curve nor modifies the slope factor (PubMed:20855463).  It does not slow fast-inactivation of hNav1. 7/SCN9A channels (PubMed:20855463).  In addition, it has only a weak affinity for lipid membranes (PubMed:18054060, PubMed:29703751, PubMed:28115115).  This toxin also exists with a pyroglutamate at position 53 (PubMed:23826086).  The sole difference observed between modified (mHwTx-IV) and unmodified toxins is that moderate or high depolarization voltages (200 mV) permit the unmodified toxin to dissociate, whereas mHwTx-IV toxin does not dissociate, even at high depolarization voltages (PubMed:23826086).  These data indicate that mHwTx-IV strongly binds to voltage sensor of sodium channel even at extreme depolarization voltages (PubMed:23826086).
What are the official names of this protein?
Huwentoxin-IV, HwTx-IV, Huwentoxin-4, Huwentoxin-IVa, HWTX-IVa, Huwentoxin-IVb, HWTX-IVb, Huwentoxin-IVc, HWTX-IVc, Mu-theraphotoxin-Hs2a, Mu-TRTX-Hs2a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 22 (Htx-4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MENG_STRCO
Sequence: MTRASLNKQPHEVASMFDHVAERYDLTNAVLSLGQDRAWRKAVARAVDARPAQKVLDLAAGTATSSLPFARTGAYVVPCDFSQGMLQVGKERHSWLPFTAGDATRLPFKDDVFDAVTISFGLRNVQDTDAALREMYRVTRPGGRVVICEFSHPTWAPFRTVYTEYLMRALPPVARAVSSNPDAYVYLAESIRAWPDQPALAGRLGRAGWSRVAWRNLTGGVVTLHRGFKAS
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RBFA_HAEDU
Sequence: MSREFKRSDRVAQELQKEIAVILQREVKDPRIGMVTVSDVEVSRDLAYAKIFVTFLFDNDQDIIAQGMKGLEKAGPYIRTLLGKAMRLRILPELRFIYDQSLVEGMRMSNLVSNVIKSDQAKHKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1511_STRU0
Sequence: MDIRQVRETIEMIEEQHFDIRTITMGISLLDCIDPNIDRAAEKIYKKITEKASQLVAVGDDIAAELGIPIVNKRVSVTPIALIGAATDATDYLPLAKALDKAAHEIGVDFIGGFSALVQKGYQKGDEILINSIPKALAETQKVCASVNIGSTKSGINMTAVADMGRIIKETAEQSDLGAAKLVVFANAVEDNPFMAGAFHGVGEADVVINVGVSGPGVVKRALEKVKGESFDILAETVKKTAFKITRIGQLVGQMASERLGVKFGIVDLSLAPTPAVGDSVARVLEEMGLEMVGTHGTTAALALLNDAVKKGGVMACNQVGGLSGAFIPVSEDEGMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPYQTIAAMIADEAAIGVINQKTTAVRIIPKGKVGDMIEFGGLLGAAPVMAVNGHSSADFIARGGQIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein SUB1511.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: IAP1_OSHVF
Sequence: MGISELEYLPQTTVNALLQYDNVRLATFRGYEYATDQWKKYLSDTKFFKVGEVDQIQCVFCRMKTSIRNEERIKKHVADCREGVVSAPQQQPPPPPSTSIGAVGGDPRPEDMNVPERGWDPPMSKDPKSTFLGKWPHSEYISIDSMVAEGFEFIGPGDRVQCRHCKVILRNWETTDIPSSEHERNAPRCPLVVQRYLTRMREDDERRDRELKEVQQRRKMDMNKAFSQDMSKLENRIASLKFWPGPIRDIEKVARTGFFYTGEKDMLTCYACACKLINWEKNDDPIKEHKINFPHCANMADVKWSDVGFSNDEECVICLGAKADTILKPCLHYSLCYGCSTQVQKCPLCRKKIEKRVQTTNVLQ
What is the function of this protein?
May act as an apoptosis inhibitor.
What are the official names of this protein?
Putative apoptosis inhibitor ORF42.
Protein: SUB8_ARTOC
Sequence: MKGLLSLSVLPVLAYASPMIVDSIHQDAAPILSSTNAKDIPDSYIVVFKKGVSSSSALAHQTWVQEIHTSTESKRLKKRNQFTFKNEAFDGLKHTFDIAGGLLGYSGHFDEEVIEQVRRHPDVEYIERDSEVRALESVTENGAPWGLARISHRKRLNFGTFNKYIYAAQGGEGVDAYVIDTGTNIEHVDFEGRASWGKTIPENDDDIDGNGHGTHCSGTIAGKKYGVAKKAHVHAVKVLRTSGSGTMSDVVKGVQWAAESHLKQVGETKKGNRKGFKGSVANMSLGGGKSVTLDRVVDQAVAVGMHFAVAAGNDNADACNYSPAASQNSITVGASTLTDERAYFSNYGKCTDIFAPGLNIQSTWIGSKYAVNTISGTSMASPHICGLLAYFLSLQPASDSAFAVAEITPAEMKENMISIASKNALTDIPADTPNLLAWNGGGSDNYKEIVGGKDNATKEHISSTLTEKLEQLAEEGLTAIYNELKDVVVA
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TLR9_FELCA
Sequence: MGPCHGALHPLSLLVQAAALAVALAQGTLPAFLPCELQRHGLVNCDWLFLKSVPHFSAAAPRGNVTSLSLYSNRIHHLHDSDFVHLSSLRRLNLKWNCPPASLSPMHFPCHMTIEPHTFLAVPTLEELNLSYNSITTVPALPSSLVSLSLSRTNILVLDPANLAGLHSLRFLFLDGNCYYKNPCPQALQVAPGALLGLGNLTHLSLKYNNLTAVPRGLPPSLEYLLLSYNHIITLAPEDLANLTALRVLDVGGNCRRCDHARNPCMECPKGFPHLHPDTFSHLNHLEGLVLKDSSLYNLNPRWFHALGNLMVLDLSENFLYDCITKTTAFQGLAQLRRLNLSFNYHKKVSFAHLHLAPSFGSLLSLQQLDMHGIFFRSLSETTLRSLVHLPMLQSLHLQMNFINQAQLSIFGAFPGLRYVDLSDNRISGAMELAAATGEVDGGERVRLPSGDLALGPPGTPSSEGFMPGCKTLNFTLDLSRNNLVTIQPEMFARLSRLQCLLLSRNSISQAVNGSQFMPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMQGVGHNLSFVAQLPALRYLSLAHNDIHSRVSQQLCSASLRALDFSGNALSRMWAEGDLYLHFFRGLRSLVRLDLSQNRLHTLLPRTLDNLPKSLRLLRLRDNYLAFFNWSSLVLLPRLEALDLAGNQLKALSNGSLPNGTQLQRLDLSSNSISFVASSFFALATRLRELNLSANALKTVEPSWFGSLAGTLKVLDVTGNPLHCACGAAFVDFLLEVQAAVPGLPGHVKCGSPGQLQGRSIFAQDLRLCLDEALSWDCFGLSLLTVALGLAVPMLHHLCGWDLWYCFHLCLAWLPRRGRRRGADALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEERDWLPGKTLFENLWASVYSSRKMLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGTALTRDNQHFYNQNFCRGPTTAE
What is the function of this protein?
Key component of innate and adaptive immunity.  TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms.  TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
What are the official names of this protein?
Toll-like receptor 9.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid.
Protein: RIMM_STRZP
Sequence: MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEKDQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYHEIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRVDVEILEGLDDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTB2_CERNC
Sequence: MVKRIEADNLFELTAELVSASSKLHKFLDQKNLPQPSFDAPAPSVALNSANKPYYDARSAIVEAAEQLIRLVRGPRDTLLALSFEHCATASMQVVFKYKFANHIPLHGSTTYSKIAEAVGDGVTTALVERTIQHCASFGLFETIPGAMLLQCYLVLLVTDPDLEAWMYLSAVIAYPAGAAIPKAVEQYGVSHEADESGYGASIGRKIAQFQRFREPDGKKDHEMFARAMRGIAAGGAYDFRHAVDGGYPWHLLAEGAGHLVVDVGGGPGHVAMALAEKYPSLRFQVQDLPETVQVGAKNCPEHLKSRVSFQSHDFFTSQPAHEVQDGEGIVYFARFILHDWSDKYATKIVQQLATGLRPQDRIILNEVVVPEAGQVGRETERRMHDRDLLMLMNLNGRERTQSAFEAIFASVTPKLRLQRVIHPEQGELSLIEVTLDGVELPAQANGVNGHANGTNGVNGH
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (PubMed:17074519, PubMed:15915645, PubMed:26938470).  The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).  These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).  The first step of cercosporin biosynthesis is performed by the polyketide synthase CTB1 which catalyzes the formation of nor-toralactone (PubMed:23108075, PubMed:26938470).  The starter unit acyltransferase (SAT) domain of CTB1 initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain.  The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (PubMed:23108075).  The bifunctional enzyme CTB3 then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening (PubMed:17074519, PubMed:26938470).  The O-methyltransferase CTB2 further methylates the nascent OH-6 of the CBT3 product, blocking further oxidation at this site before the reductase CTB6 reduces the 2-oxopropyl ketone at position C7, giving naphthalene (PubMed:17660442, PubMed:26938470).  The FAD-dependent monooxygenase CTB5 in concert with the multicopper oxidase CTB12 are responsible for homodimerization of naphthalene with CTB7 installing the dioxepine moiety, finally producing cercosporin (PubMed:17660442, PubMed:30809363, PubMed:26938470).  The fasciclin domain-containing protein CTB11 might act with CTB5 and CTB12 whereas the roles of CTB9 and CTB10 have still to be elucidated (By similarity).
What are the official names of this protein?
O-methyltransferase CTB2, Cercosporin toxin biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: SBCD_STAAT
Sequence: MKIIHTADWHLGKILNGKQLLEDQAYILDMFVEKMKEEEPDIIVIAGDLYDTTYPSKDAIMLLEQAIGKLNLELRIPIIIISGNHDGKERLNYGASWFEHNQLFIRTDFTSINSPIEINGVNFYTLPYATVSEMKHYFEDDTIETHQQGITRCIETIAPEIDEDAVNILISHLTVQGGKTSDSERPLTIGTVESVQKGVFDIFDYVMLGHLHHPFSIEDDKIKYSGSLLQYSFSEAGQAKGYRRVTINDGIINDVFIPLKPLRQLEIISGEYNDVINEKVHVKNKDNYLHFKLKNMSHITDPMMSLKQIYPNTLALTNETFNYNEENNAIEISEKDDMSIIEMFYKHITDKELSDIQSKKIKNILENELRKED
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.
Protein: ECFA2_STRPN
Sequence: MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGSGKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEETVLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGILAMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVMEKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKESLNG
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UVRC_BURL3
Sequence: MTSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSSLATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGIGDESELAEAVDAPADAMPDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNAQIALMRLLSEQGSQQARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORML2_CHICK
Sequence: MNVGVAHSEVNPNTRVMSSRGIWLAYVISVAALHVILLSIPFFSIPVVWTLTNVIHNLVMYLLLHTVKGTPFETPDQGKDRLLTHWEQIDYGMQCTSSRKFLSISPVVLYLLTSFYIKYDPAHFMINTASLLSVLLPKLPQFHGVRVFGINKY
What is the function of this protein?
Negative regulator of sphingolipid synthesis.
What are the official names of this protein?
ORM1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the ORM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LEG10_HUMAN
Sequence: MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
What is the function of this protein?
Regulates immune responses through the recognition of cell-surface glycans.  Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
What are the official names of this protein?
Galectin-10, Gal-10, Charcot-Leyden crystal protein, CLC, Eosinophil lysophospholipase, Lysolecithin acylhydrolase.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Protein: CYB5B_HUMAN
Sequence: MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCKSCWAYWILPIIGAVLLGFLYRYYTSESKSS
What is the function of this protein?
Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
What are the official names of this protein?
Cytochrome b5 type B, Cytochrome b5 outer mitochondrial membrane isoform.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: DUT_PSEMY
Sequence: MHALQAKILDPRLGQEFPLPQYATPGSAGLDLRAMLKEDIVLEPGQTVLIPTGLSIYIGDPGLAAMILPRSGLGHKHGIVLGNLVGLIDSDYQGELMVSCWNRGHTPFTIAIGERIAQLVLVPVVQAHFELVEQFDETQRGAGGFGHSGSH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RBSD_CROS8
Sequence: MKKGTVLHSGISSVISRLGHTDTVVVCDAGLPIPSTTERIDLALTQGVPGFLQVVDVVTQEMQVEAAILAEEIKQHNPQLHETLLGQIERLQQHQGNTITVRYVSHEQFKLKTADSQAVIRSGECSPYANIILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESAM_HUMAN
Sequence: MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV
What is the function of this protein?
Can mediate aggregation most likely through a homophilic molecular interaction.
What are the official names of this protein?
Endothelial cell-selective adhesion molecule.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Protein: RL36_LEVBA
Sequence: MKVRPSVKPMCEHCKVIKRKGRVMVICSANPKHKQRQGK
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MIAB_THESQ
Sequence: MRFYIKTFGCQMNENDSETMAGLLMKEGFTPASAPEEADVVIINTCAVRRKSEEKAYSELGQMLKIKRKRKLVVGVAGCVAEKEREKLLERGADFVLGTRAVLKVTEAVKRALQGEKVALFEDHLDEYTHELPRIRSSKHHAWVTIIFGCDRFCTYCIVPYTRGREKSRPMEDILEEVRELAKQGYREVTFLGQNVDAYGKDLKDGSSLAKLLEEASKIEGIERIWFLTSYPTDFSDELIEVIARNPKVAKSVHLPVQSGSNRILKLMNRSYTKEEYLALLERIRSKVPDVAISSDIIVGFPTETEEDFMETIDLVEKAQFERLNLAIYSPRKGTVAWKHYKDEVPYEEKVRRMQFLMNLQKRINRKLNERYKGKTVRVIVEAQAKNGLFYGRDIRNKIIAFEGEEWMIGRFADVKIEKITAGPLYGKVVWIEETPSPVSTDK
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.