PharMolix/UniProtQA huggingface dataset:
Protein: CO4_RAT
Sequence: MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKKEVFAPTSIFQDDFIIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDVQARYVYGKPVQGVAYTRFALMDEQGKKSFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMSGSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSLYPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYYYMIISRGQIMAMSREPRRALTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGDSMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARAQDMLQEEDLIDEDDILVRSFFPENWLWRVEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASIPLKVVARGSFTIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASITKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLQNVAHNSLMAMAEETGENLYWGSAIGSQDNVVSSTPAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKVATWLTHQGSFQGGFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFACYYPRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRLRLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNTWIEEMPSERLCRSTRQRAACGQLNDFLQEYSSQGCQV
What is the function of this protein?
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes.  It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
What are the official names of this protein?
Complement C4.
What are the subcellular locations of this protein?
Secreted. Synapse. Cell projection, axon. Cell projection, dendrite.
Protein: IMP2L_XENLA
Sequence: MAQHGRRYVRAFISGFFVAVPVTVTFLDRVACIARVEGVSMQPSLNPDARGESDIVLLNRWRARNYDVQRGDIVSLVSPKNPEQKIIKRVIALEGDIVKTLGHKNRYVKVPRGHVWVEGDHHGHSFDSNAFGPVSLGLLHSHATHILWPPNRWQKLKPFLPVERESVQND
What is the function of this protein?
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
What are the official names of this protein?
Mitochondrial inner membrane protease subunit 2, IMP2-like protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family. IMP2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PG135_VAR67
Sequence: MSCYTAILKSVGGLALFQDANGAIDLCRHFFMYFCEQKLRPNSFWFVVVRAIASMIMYLVLGIALLYISEQDDKKNTNNASNSNKLNESSINSNS
What is the function of this protein?
Envelope protein.  Required for an early step in virion morphogenesis.
What are the official names of this protein?
Virion membrane protein OPG135.
What is the protein family that this protein belongs to?
Belongs to the oerthopoxvirus OPG135 family.
Protein: SYD_CLOBB
Sequence: MGEALNGLKRTMMCGEPREEHVGQKITLMGWVQRNRKLGGLDFIDLRDKTGIMQVVFGEEINSEAFEKAKSVRPEYCIAVTGEVVKRESVNENMPTGFVELKCESLKILSESETPPIYIKENLDAAENIRLKYRYLDLRRPDMHRIFEIRSKTTKSIRDYLEKNDFLDVETPMLTKSTPEGARDYLVPSRNYRGMFYALPQSPQIFKQLLMVSGFDKYYQIVKCFRDEDLRANRQPEFTQVDMELSFVEQDDIMALNEGLIAHVFKEVAGVDVKLPIKRMTFKDAMEKYGSDKPDLRFGMEITNITEDVKDMDFVVFKSAIEAGGSVRALCLKGGATLGRKPLDKLGEFVKTYKAKGLAWIQLKEDGVKSSIAKFLTDDVTNSIIETMGAETGDAILIVADKESVVFQSLGALRLELAKQFELIKDKNEFNFTWITEFPLFEYSEEEERYTACHHPFTAPMEEDLEFLESAPGKVRSKAYDLVLNGEELGGGSIRIHDMELQQRMFKALGFTEEQAWERFGFLLQAFKFGPPPHGGLAFGLDRMIMFLAGTENIKDVIAFPKNQNAYCYLSEAPNIADEKQLTELGIGILPKQEKQEQE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAA_PICTO
Sequence: MKIYIIDNGGQWTHREWRTVRDLGVDSTIVPNTVDADVLADADGIILSGGPASIESEISKLGNIKEYMHRYNYPVLGICVGAQFIAIDSGGRVSKALHAEYGKKIVNFTSKDGIFYNIPDSINAWENHNDEIKSISDDYIICAYSDTCRVQAFYHKNRDIFGVQFHPEVNNTEHGTTIFKNFIEKCRR
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: PSBC_POPAL
Sequence: MKTLYSLRRFYPVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRALVWSGEAYLSYSLGALAVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y3592_ENT38
Sequence: MLTVCWFLYLVRTADNALYTGITTDVGRRFLEHQTGKGAKALRGKGELSLAFSAPVGERSLALKMEYRIKQLTKRQKERLVAGDGSFEALYESLQTPPVKRD
What are the official names of this protein?
UPF0213 protein Ent638_3592.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: RS19_STRU0
Sequence: MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MURB_MAGMM
Sequence: MKGSHGPCSDLTVTMLENVPLAPLTTLKIGGNARWLVRPSGVKGLSRYCRTCPGDLPRFILGGGSNLLVDDNGFHGVVVDLTHTLNAIVVEHQDAHGGILRVEAGAATRKTAHVARQNGLAGLAFMAGIPGTIGGALRMNAGAYGCDVKGVLLDAQLMDATGNLHTRNAQELGLAYRHCDLPKGWIFVSARFHLARGESEAIKSQMRDYNHKRTQAQPLRYPSAGSVFRNPAGAAAWQLIDAAGLRGHRIGDAQISEKHSNFFVNLGAASSLHMEELIELARNRVAQHSGVQLTLEIGILTPQGLRTEPGR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAB21_CAEEL
Sequence: MLGHNQNVVYQVNNYFNEKVQHRKVRVTKTVQRIAKVVQEILKEVEAQEPRFINTLSETTTGRFDGIVVHSPSEYEAVLYLNQMGVFNFVDDGTIQGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRHRFQNIVAQVLQTPQFSDYCKLLQDNTDVRVRVDDKYTVQITCAFRCNGIWPRSASHWPIAGLPWPNAALANQTKAEGFDLTSRETAITQQNNPNKQASSMEADAWAMKMHGAENMLLTGGRRKTLSILKCLRDAHMDFPGTPVTNYILKTLVLYECEKHCSEYEWEDPNIGDRLVGILLQLVSCLQCRRCAHYFLPSLDLLRSKPVHSIEHSAQLAWHLVRKLMIDPNALQSL
What is the function of this protein?
Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate.
What are the official names of this protein?
Protein male abnormal 21.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: GLMM_PYRAB
Sequence: MGKYFGTSGIREVVNEKLTPELALKVGLALGTYLNGGRVVIGNDTRTSSEMLKKAVISGLLASGVDVIDIGLAPTPLVGFAIKLYDADAGVTITASHNPPEYNGIKVWDRNGMAYTPEKERELERIIEEEKFKRAPWNEIGQLKQANPREEYIEAIMKEIKLDNSYTVVIDPGNGAGSIISPYLHRELGNRVITINSDPHGFFVRELEPNKESLSMLAKTVKALKADIGIAHDGDADRVGVVDENGEFVEYEVMLSLIAGYMLRKYGKGKVVTTVDAGFALDDYVRGLGGEVVRTRVGDVAVAEELMKHGGVFGGEPSGTWIMPQWNLTPDGIFAGALVLEMIDRLGLIGELAKEVPRYVTLRKKIPCPNDLKAKAMEEIAKLIPREFSYEREITIDGIRIENDDWWILFRPSGTEPIMRITLEAHTKERAESLMEKAEKLVKDAIKKASS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Probable phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: NUOCD_BUCBP
Sequence: MKKEIKRDDVNVIEKDFGNNNSIILKLFKKFGEDSFFIQTTVTDIIVLWIDGSLLLALAKFLLTINNPYNMLFDLYGIDERMRLYKHNLPLSHFSVVYHFISINRNSDIILKIALLEEKLSLPTLTKLYPNANWYEREIWDMFGISFENHPNLIRILMPKTWVGHPLRKDHPARATEFDPYVLNKYKEDIEMEALKFKPEEWGMKKNKQSKYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPDIGYHHRGAEKMGERQTWHNYIPYTDRVEYLGGCINEMPYVLAVERLAGIEVSQRIEVIRIMLSELFRINSHLLFISTFIQDVGAMTPVFLAFTDRQKIYDLIELITGSRMHPAWFRIGGLAHDLPKGWNALLKEFLLWMPKRLLKYINVALKNSILISRSKGIAEYNKHDALLWGVTGAGLRATGINFDVRKKRPYSGYQNFDFEVPIGAGISDCYSRVMLKLEEIWQSLAILKQCLENMPEGPFKMDHPNTTPPHKVRTLQHIETMISHFLKVSWGPVLSSNESFKMVEATKGINSYYLISDGNTMSYRTRIRTPSFPHLQQIPSVIRGNLISDLIAYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BTUD_VIBCM
Sequence: MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDVSQASLSELARHRAYLAQNNKPSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNIDDKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIWDEPAAPLDIAQESLLYRLIERMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRVELEGHPHLLFD
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATL12_ARATH
Sequence: MNSPQEISILFFFIIFLDYVSAQSPPPPNLYATSDLFKPSLAIITGVFSIVFTLTFVLLVYAKCFHNDLRSETDSDGERIRHDRLWQGLFNRSSRFSGLDKKAIESLPFFRFSALKGLKQGLECSVCLSKFEDVEILRLLPKCRHAFHIGCIDQWLEQHATCPLCRNRVNIEDDLSVLGNSSTSLRILNQSETREEDSRLEIYIEREEGTNDGSSRFSSFRKILKKSLLLEREGNENIDEKKLMHKFNHRIVVSDAVFKNRWSNITSSDLTFLTSEMLNSVSSDRFSSVDRVHRGNLRDKEDMEMKRMLIKHKDSSRRTVSEITTVSREKAVGGSYRGSTASTSQNYAVTATTEERRRRLWLPIARRTAQWFVNREKSNDLNTTRQNLNV
What are the official names of this protein?
Putative RING-H2 finger protein ATL12, RING-type E3 ubiquitin transferase ATL12.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYA_NITEU
Sequence: MKSSEIRQKFLEFFEARGHVIVPSSPLVPGNDPTLLFTNAGMVQFKDVFLGQDKRPYVRAVSSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRKAILFAWEFLTGSLGIPREKLWATVYAEDDEAADIWLNEVGIDPSRLVRIATSDNFWQMGDTGPCGPCSEIFYDHGPAVAGGPPGSENAEGDRYIEIWNLVFMQYNRDASGELHPLPKPSVDTGMGLERIAAVMQQVHSNYEIDLFRSLIEAAARVTGSKDLSNNSLKVIADHIRACAFLITDGVIPGNEGRGYVLRRILRRAIRHGYRLGQKQPFFYLLVDDLVDVMGPAYPELTRARKHVAGVIRQEEERFAETLENGMEVLEAALSHGNETLSGEIVFRLYDTFGFPVDLTADIARERGIVIDMAGFETCMAQQRDRARASGKFTMQTGLEYTGQPTEFHGYATLQHEAQILALYKQGSRVDFIEADDEAVVVLDQTPFYAESGGQAGDSGELLSGSGTFTVNDTQKIQAGVFGHNGMLSSGRMAIGDRVIARVDQIARTNTAYNHSATHLLHAALRQVLGNHVTQKGSLVDASRLRFDFSHNSAMQENEIRQVENLVNAQIRKNHEVATQLMTYDDAVKQGAMALFGEKYGDTVRVVAMGDFSTELCGGTHVSYSGDIGFFRIVAESGVAAGIRRIEALTGDAALAYTQQQEQQLQQVADALKAAPQEAAQKLSQILDNIRQMEKEIATLRSKLAGVQSTSLIEQAQEIKGIRVLATTLENVNVKTLRETLDNFKNRLKSCVVVLGTIEKDKVTLIAGVTDDLTVKLKAGDLINFVAQQVGGKGGGRADMAQAGGTLPEKLPQALASVPSWVEQNL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO1C_PYRFU
Sequence: MVSLSTIKSLIEKKGANLPENVKSELYEKLKKYNEKYKLTKAEIEAIIDDVVKEYERALVEPGEPVGTVAAQSIGEPSTQMTLNTFHYAGVAEINVTLGLPRIIEIVDARKNPSTPMMTVYLDEEHRYDRAKAEEVARRIEGTTLENLARSTTLDLINFEFIVEIDPERLERSGLTMEKVVKKLESSFKSAEFEVDGYTLIVRPKKADKISDLRRFAEKIKKHRLKGLSGVGKTIVRKEGDEYVIYTEGSNFKQVLKVPGVDPTRTRTNNIHEIAEVLGIEAARNAIIDEIVSTMQEQGLEVDIRHIMLVADMMTLDGIVRPIGRHGVVGEKSSVLARAAFEITVQHLFEAAEKGEVDNLNGVIENVLIGQPVPVGTGMVKLTMKLPLRPQKEKEEV
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESRP2_DANRE
Sequence: MASHSDTLVVFFGATAGANGGKLGSDERELILLVWQIVDLHENKVGKLHRTLVQPDSVDLSEQCKEETGLTAEELCKAEPLESVLQQFHQSVSAELKSLGRSSYTLCVDGPLLIRQVLHPEASKKNLVLPECFYTFVDLKKEFHKCCPNAGPVKDLTLLSMLDYVCIQATVEQEAGLREVKDMVLLILHVLADPYNHKFSAFETVNYKFESGACSKTEAVDSETVIRARGLPWQSSDQDIARFFKGLNIAKGGVALCLNAQGRRNGEALVRFINSEHRDMALDRHKHHMGSRYIEVYKATGEEFLKIAGGTSNEVAQFLSKENQMIIRMRGLPFTATPQDVLGFLGPECPVTDGTEGLLFVKYPDGRPTGDAFVLFACEEYAQNALKKHKQILGKRYIELFRSTAAEVQQVLNRYMSTPLISTLPPPPPPMVSVPVLATPPFITTGNTRDCIRLRGLPYTAAIEDILEFMGEHTIDIKPHGVHMVLNQQGRPSGDAFIQMKSADRAFMVAQKCHKKMMKDRYVEVFQCSTEEMSFVLMGGTLNRSGLSPPPCKLPCLSPPTYAAFPAAPAMLPTEAALYQPPLLATPRTPQAPTHSPAPAFAYYSPQLYMNMNMSYTTYYPSPPVSPSTVSYFAAPPGSVAAAVAAQPTPAILPPQPGALVRMQGLPYNAGVKDILSFFQGYQLQADSVLVLYNWSGQRSGEALVTFPSEKAARRAVAECSNIPLSGHPIHLACCE
What is the function of this protein?
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms.  Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2.  Acts by directly binding specific sequences in mRNAs.  Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).
What are the official names of this protein?
Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B, RNA-binding protein 35B.
What is the protein family that this protein belongs to?
Belongs to the ESRP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRUB_WIGBR
Sequence: MIYLIIILLKFQKNLYDLLYSVIIKEDYLRNINGILLLDKPIGLSSNLILQKIKKLFKAKKAGYIGTLDPIASGMLPIFFGDATKFSDYLLNTNKWYKIKAKLGEKTNTLDSFGKIICIRPILNIKKLNIEKILSEFQGEIYQKPPMFSSLKHLGKPLYKYARQGIYIPREKRKVYVHYIKLLSFSKKYFSLTIKCSKGTYVRSIVDDIGEKLFCGAHIVKLRRTKLFNYKESHMIDSNKLYNIKKKFNDLKKLDECLLPIESIFKKLPIIVVNDDIINRLRNGIKLNFWKIKKNNLFKIISKDTKKFVGIIDINKYGRANSIKLIK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: OBG_CERSK
Sequence: MKFLDLCKVYIRSGGGGGGCVSFRREKFIEFGGPDGGDGGNGGSVWAEAVDGLNTLIDFRYQQHFFAKSGQPGMGSQRTGRSGDDIVLKVPVGTEIIDEDEETVIADLTEVGQRVLLAQGGNGGWGNLRFKSSTNRAPARANPGQPGIDRTIWLRLKLIADAGLLGLPNAGKSTFLSATSNARPKIADYPFTTLVPNLGVVGVDGKEFVIADIPGLIEGASEGRGLGDQFLAHVERCSVLLHLVDGTSSTIVKDYRTIIGELEAYGGDLALKPRITAMNKIDAMDSKQISDRRRALEKATGGKVFTISGVAGTGLMDVLRALWAEIDGARGDKVEEHAPWQP
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPFUR_ECOLI
Sequence: MIRIISRANSVTSSNEVNRLVTGQIPHD
What is the function of this protein?
Cotranscribed with fur, it is essential for fur translation.  The fur ribosomal binding site (RBS) is occluded by the 5'-mRNA secondary structure, which is opened by uof translation.
What are the official names of this protein?
fur leader peptide.
Protein: MALT_YERPP
Sequence: MLIPSKLSRPVRLQNTVVRDRLLVKLSSAANYRLTLINCPAGYGKTTLIAQWAADQSNLGWYSLDESDNQSERFATYLIAAIQLATGGHCSKSEALSQKHQYANLSALFSQLFIELSNWDGPLYLVIDDYHLITNDAIHEAMRFFLRHQPENLTLIILSRTLPSLGIANLRVRDQLLELGMQQLAFNHHEAQQFFECRLSSPLEQGDSSRLCDEVEGWVTALQLIALSSRQPNSSAQKSAKRLAGLNASHLSDYLVDEVLDQVDSKARAFLLRCSVLRSMNDALIVRLTGEDNGQQLLEELERQGLFIHRMDDSAEWFCFHPLFATFLRQRCQWELALELPELHHAAAEGWMALGYPAEAIHHALAAGDVGMLRDILLQHAWSLFHHSELALLEQCLTALPYPLLVQNPELALLQAWLAQSQHRYSEVNTLLEQAELAMQERKIPVDEILRAEFGALRAQVAINAGKPDEAEKLATDALKYLPMAHYYSRIVATSVTGEVHHCKGELARALPMMQQTEQMARRHEAYHYALWALLQQSEILIAQGFLQAAYETQEKAFELIREQHLEQLPMHEFLLRIRSQVLWSWSRLDEAEEAARKGVEILANYQPQQQLQCLAMLAKCSLARGDLDNANVYIQRCEALQHGSQYHLDWITNADKPRVIHWQMTGDKVAAASWLRQTEKPGMADNHFLQGQWRNIARVQIILGRFDEAEVVLDELNENARRLRLTSDLNRNLLLSNTLYWQTERKGEAQKALIESLTLANRTGFISHFVIEGEAMAQQLRQLIQLNALPELEQHRAQRILKDINQHHRHKFAHFDEIFVDKLLTHPQVPELIRTSPLTQREWQVLGLIYSGYSNDQIANELDVAATTIKTHIRNLYQKLGVAHRQEAVQQAQRLLQMMGYV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.
Protein: SOST_MOUSE
Sequence: MQPSLAPCLICLLVHAAFCAVEGQGWQAFRNDATEVIPGLGEYPEPPPENNQTMNRAENGGRPPHHPYDAKDVSEYSCRELHYTRFLTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVRLVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPGARGAKANQAELENAY
What is the function of this protein?
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
What are the official names of this protein?
Sclerostin.
What is the protein family that this protein belongs to?
Belongs to the sclerostin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: NRAM2_MOUSE
Sequence: MVLDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYITVKPSQSQVLRGMFVPSCPGCRTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNKQVVEVCKNNSSPHADLFPSDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLIVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLTFVFYLGWQCLIALGLSFLDCGRSYRLGLTAQPELYLLNTVDADSVVSR
What is the function of this protein?
Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16475818).  Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16475818).  Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (PubMed:11739192).  Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity).  Can mediate uncoupled fluxes of either protons or metal ions.
What are the official names of this protein?
Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Also found in extracellular vesicles different from exosomes.