PharMolix/UniProtQA huggingface dataset:
Protein: SYP_ACISJ
Sequence: MKASQFFISTLKEAPADAEVVSHQLMMRAGLIKKLGAGIYNYMPMGLRVIRKVEAIVREEMNRAGAVECTMPVVQPAELWQETGRFDKMGPELLRIHDRHGRDFVIQPTSEEVVTDIARQELRSYKQLPKNLYQIQTKFRDERRPRFGLMRGREFIMKDAYSFDRDQAGAKASYQVMAQAYRRIFDRFGLRYRAVAADSGAIGGDLSEEFQVIAATGEDAIVYCPASDYAANMEKAEALAPAGARPAAKQPLTVTPTPGKSTCADVAELLSVPLSTTVKSLVLATDETDAAGEIIRSQVWLLLLRGDHDMNEIKVAKVPGLDAGFRFATVAEIADHFGCKPGYLGPLNLQKPVKLVVDRDVAVMADWICGANQEGHHITGVNWGRDLPEPDMVADLRNVVAGDLSPDGQGELAIERGIEVGHVFYLGTKYSKAMNATFLGEDGKPAFFEMGCYGIGVTRLPAAAIEQNHDERGIIWPDAIAPFTVVICPVGMDRSEAVKAQAESLYADLLAAGVDVILDDRGERPGAMFADWELIGVPHRVTIGDKSLKEGQVEYQHRRDASATKVGVADILAHVKERLAA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y858_METMJ
Sequence: MPDYLVTLESAWIIKDVKSMDDAVSIAISEAGKRLNPSAKFVEIEAGMIACPFCEGELNTALVVAATALVGLVLQMKVFRAESEEHAARIAKSVVGKALHDVPLKVQEVQEL
What are the official names of this protein?
UPF0212 protein Memar_0858.
What is the protein family that this protein belongs to?
Belongs to the UPF0212 family.
Protein: THIM_BACCR
Sequence: MNMKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPEEVEAMLLAGKSANVNNVPVLFDPVGAGATSYRTEVARHIPAEIELASIRGNAAEIANVINERWEIKGVDAGTGNGNVVSIARQAADELNTVAVITGKEDVVTDGERTIVIRNGHPILTKVTGTGCLLTSVIGAFVAVEKDYVKAAVAALTFYGVASELAAAKTVEKGPGSFQIEFLNQLANTTSSDIEKYGKIEELE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: Y395_STAAB
Sequence: MKCFQKLYIFILILIVLMAGCESNKITGDSKETQIKKSFAKTLDVYPTKNLEDFYDREGYRDGEFKKGDKGKWVIRSEITTELKNENMVSKGMVIRLNRNSRTCTGEYFVRIVKEDSEGKVYSDERKYPVKMENNKIIPLKPIDDEKVKKEIEEFKFFVQYGNFKELENYKEDEVSYNPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTKKAPKLLLKGSGNLKDSSVGYKNIEFTFIENKEENIYFTDSIYFNPSVDK
What are the official names of this protein?
Uncharacterized lipoprotein SAB0395.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PHRB_SYNPZ
Sequence: MFDAFTKVVAQADARGQFISTSEIDALAAMVSDSNKRLDAVNRISSNASTIVASAARQLFAQQPALIAPGGNAYTSRRMAACLRDMEIILRYVTYSAFTGDASVMEDRCLNGLRETYLALGTPGASVAAGVNLMKDAALAIINDKAGISAGDCASLSSEIGTYFDRAAASVA
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.
What are the official names of this protein?
R-phycocyanin-2 beta chain, R-phycocyanin II beta chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: RK4_CYACA
Sequence: MKFMVTEQKTLIYPVINLITGQHNYIGFKCRISTNNANYVVHRVFSIQNKLSREHTASTKTKSQVRGGGKKPWKQKGTGRARAGSIRSPLWRGGGVVFGPKPKNVFFKINKKEIRLALYTVLSNALPKTTVVSSLEGLPNFISTQALIKFLRSLNVSLDNRVLIVVEKKETPLFLSCRNIKNLALIQADHLNVKSVILAQSLVVTLQALKIIYKTFNDN
What is the function of this protein?
Probably binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYY_ACHLI
Sequence: MDLFKQLEYRGMVKDVSDLELAKQLLNEQKIKFYVGYDPTGESLTVGHLVQIVRMLYLQKHGHTPVVLIGGGTGLIGDPRETSERSLLTLEKSLENAQKIENQIKGLIKGNVEFVNNYEWLSKIDLISFLRDYGKHFSVSYMLHKDTVQKRLESGISYTEFSYMILQSIDWLNLYQNRDVKIQFGGSDQWGNLTSGLELIRRVLGKNDAVGLSSPLLLKADGTKFGKSESGALWLDKELTSPYELYQYFLNSSDTDIEQFLKLLTLIEQDEIEAILETHREKPELRHAQKVLAKAVVELVHGKEELETALQVTEALFSGEFNGLTKSAYKTLESVIDVVRFNGESLIELVVKSKLASSNREAREFISNGAISIQGEKITDSMYNVGETSKAFDTYAIIRRGKKKYALIVF
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_BRUA1
Sequence: MTQQRPPLEIRLCGPRGFCAGVDRAIQIVVLALKKYGAPVYVRHEIVHNRYVVEGLQARGAIFVEELDEIPAAHRNQPVVFSAHGVPKSVPADAEAKNLFYLDATCPLVSKVHKQAMRHQRLGRHVILIGHSGHPEVIGTMGQLPDGAVTLIETVEDAHTCHFDDEDNLGFVTQTTLSVDDTAGIIKELQARFPNLAAPAAESICYATTNRQDAVRAAAPGCDLFLIVGAPNSSNSKRLVEVAEKAGARMSMLVQRAEDIEWEQIGDISVVGLSAGASAPEIIVDEIIDAFKARFDVKIELAETTVETENFLVNREIRDVELTVKDMAFVNGEHRVVGISKLMQGK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: ACP_ALKEH
Sequence: MSSIEERVKKIVVEQLGVKEEEVSGEASFVDDLGADSLDTVELVMALEEEFECEIPDEEAEKITTVQQAVDYINKHLGS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_ERWT9
Sequence: MYQDIIRSELNEAADTLNKFLSDEANIAAIQRAAVLLADAFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYDYVFSRYVEAVGKAGDVLLGLSTSGNSANIIKAVEAARAQGMKVIALTGKDGGKMDGLADVEIRVPHFGYADRIQEIHIKVIHILMLLIEKEMVK
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMR_MYCTO
Sequence: MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAPLHRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHPGDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRVSTAQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEFERDRLITVGYAVIEITDQHGLRARAQ
What is the function of this protein?
Positively regulates the expression of at least groEL2.
What are the official names of this protein?
HTH-type transcriptional regulator Cmr.
Protein: GPSB_STRPZ
Sequence: MTSIIYSPKDIFEQEFKTSMRGFDKKEVDEFLDNVIKDYENFNAQIEALKAENEALKKAKYQARNTVSATVQQPVPQPTRVAQSATNFDILKRISKLEKEVFGKQIIE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: KRA45_HUMAN
Sequence: MVSSCCGSVSSEQSCGLENCCRPSCCQTTCCRTTCCRPSCCKPQCCQSVCYQPTCCHPSCCISSCCRPYCCESSCCRPCCCQTTCCRTTCCRTTCCCPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCHPSCCESSCCRPCCCVRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 4-5, Keratin-associated protein 4.5, Ultrahigh sulfur keratin-associated protein 4.5.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 4 family.
Protein: TRMFO_STRS7
Sequence: MSQSYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATPQHKTTHFAELVCSNSFRGDSLTNAVGLLKEELRRLDSIIMRAGEAHRVPAGGAMAVDREGYAKAVTAELEAHPLVEIIREEVTDIPSDAITVIATGPLTSDSLAEKIHALNGGAGFYFYDAAAPIVDKSTINMDRVYLKSRYDKGEAAYLNCPMTKEEFMAFHEALTTAEEAPLNAFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYKGPRDGDFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLEHAEFVRYGVMHRNSYMDSPKLLTQGFQSRANHRLFFAGQMTGVEGYVESAASGLVAGINAARLFKEEEPLVFPNTTAIGSLPYYITHADSKHFQPMNVNFGIIKELDGPRIRDKKERYEAIAKRALADLAAYLTV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_CLOK5
Sequence: MEKLGLNQIREMYLSFFEKKAHLRLPSFSLVPQNDKSLLLINAGMTPLKPYFTGLKVPPSKRVATCQKCIRTGDIENVGKTSRHGTFFEMLGNFSFGDYFKKEAIPWAWEFITEVLKLPKDRLYVTIYLDDDEAYDIWVKSTDVDPSKIFRLGKEDNFWEHGVGPCGPCSEIYYDRAQEKINSVEEFVEAADNDKIVEFWNLVFTQFDKDENGNYNRLSNPNIDTGMGLERMATIMQGENSIFEVDTINAILKEVCNISGTKYNEHKNNDISIRIITDHIRSITFMISDGILPSNEGRGYVLRRLLRRAAKHGKSLGIDDRFLYKLSNVVIDNSCESYPKLKDRKEYIKKVIRLEEERFDETIDSGMKILNEFIEELENSNSLLLEGEKAFKLYDTYGFPIELTEEILQEKNMGVDLEGFNKKMQNQKEMARSARTETNYMGAEDTVLNKIPLYIDTVFEGYNSLESTSKVKLMIKEGEFVSLLSQGEKGVILVANTPFYAEMGGQVGDKGIIYNENFEGKIIDCKNNVAGKILHFVEVISGSVSLEDTVLLKVDKNRRDDIRRNHTSTHLLGEALRRVLGEHVHQSGSYVDEHRLRFDFNHFESLNDKQLREVEELVNENIRKAKTVNTNLMSLEEAKKSGAVAIFDSKYSDEVRVVSIGDFSRELCGGTHVGNSGEIGLFKIVSEAGIAAGIRRIEAVTGREAVEYLYSKSDMLKEIANKFKCSEKEIVHKLDLQFNELRELRKELEEFKIKLAGSAEESILNGVKIVKGINLFTGILKDVDGNALRELADKIRSKSQNAVVLLGSNAEGKVNLVAMATKDAVEKGVHCGKIIKEVAAVAGGGGGGRPDMAQAGGKFPDKLEEAIGKCSAIMEKIVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELU_PSEPW
Sequence: MRHDCTDFRQLFLDDVPMMDMRAPVEFAKGAFPGVVNLPLMTDQERQKVGTCYKQQGQAAAITLGHQLVSGTLKRERLHAWASFAKAHPDGYLYCARGGLRSLIVQQWLRDEAGIAYPRIKGGYKALRTFLLDTTQQAVEQCDFVLVGGLTGTGKTDVLHQLNNVIDLEGHANHRGSSFGKRATAQPAQIDFENKLAIDVLKKRARGIEQFVLEDEGRIVGSCTVPLELYQGMQQYPLVWLEDSFENRVERILRDYVINLCAEFVALHGEELGRRLFAERLLQSMSNIHKRLGGERYQRLSEIMRLALDEQQRSGGIDLHRGWIEGLLKEYYDPMYAYQRDAKADRVEFAGDAVEVREYLKARNR
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: COBH_MYCBO
Sequence: MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE
What is the function of this protein?
Catalyzes the conversion of precorrin-8X to hydrogenobyrinate.
What are the official names of this protein?
Precorrin-8X methylmutase, HBA synthase, Precorrin isomerase.
What is the protein family that this protein belongs to?
Belongs to the CobH/CbiC family.
Protein: IL1A_FELCA
Sequence: MAKVPDLFEDLKNCYSENEEYSSEIDHLTLNQKSFYDASYDPLHEDCTDKFMSPSTSETSKTPQLTLKKSVVMVAANGKILKKRRLSLNQFLTADDLEAIANEVEEEIMKPRSVAPNFYSSEKYNYQKIIKSQFILNDNLSQSVIRKAGGKYLAAAALQNLDDAVKFDMGAYTSKEDSKLPVTLRISKTRLFVSAQNEDEPVLLKEMPETPKTIRDETNLLFFWERHGSKNYFKSVAHPKLFIATQEEQLVHMARGLPSVTDFQILETQS
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.
Protein: HTRA2_DROPE
Sequence: MALRCINNLEIFLRRCTAPTLHRCCVASSRTAHTASSSKGSGGDNSKDQENNGQNKSGYRRFGWRSVFQFCVPFSLGALVSAVLIEGHRDELTPTISARSLKGRRNEFNFIADVVAGCGDSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIHVSGLPVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISATQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGSAHKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLMHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALAEGRKDLEIVILRGVKQMHVKITPEDP
What is the function of this protein?
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein.  Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism.  Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
What are the official names of this protein?
Serine protease HTRA2, mitochondrial, High temperature requirement protein A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment. The extramitochondrial protein does not diffuse throughout the cytosol but stays near the mitochondria.
Protein: CYSJ_ECOK1
Sequence: MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLAASLSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: AROQ_MANSM
Sequence: MSQLSRILLLNGPNLNMLGAREPKHYGTLSLAAIEANVQALAAKNNIELECFQANSEEKLIDKIHQSFKKVDFILINPAAFTHTSVALRDALLAVAIPFVEIHLSNIHKREPFRHHSYFSDVAEGVICGLGAKGYECAFEFAVEFLAKKA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: BACE2_HUMAN
Sequence: MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
What is the function of this protein?
Responsible for the proteolytic processing of the amyloid precursor protein (APP).  Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.  It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112).  Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis.  Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.  This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390).  Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).
What are the official names of this protein?
Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.
Protein: INS2_CONKI
Sequence: MTTSSYFLLVALGLLLYVCQSSFGNPHTRDSGTTPDRDHSCGGELVDRLVKLCPSNRKRRGFPSMLKARAKRNEAFLLQRDGRVIVGDCCDNYCTDERLKGYCASLLGL
What is the function of this protein?
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:30747102).  It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (INSR) and assembly of the hormone's hexameric storage form (By similarity).  Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with a moderate potency (EC(50)=373. 2 nM) (PubMed:30747102).  In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with a lower potency than human insulin (PubMed:30747102).  In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency (By similarity).  When tested on a mouse model of diabetes, this insulin also lowers blood glucose with a 20-fold lower potency than human insulin (By similarity).
What are the official names of this protein?
Con-Ins K2, Insulin K2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y494R_PBCV1
Sequence: MIDIPKRDTQADKDFSKLTFKLSKHKLKKTKKFDETSKFSTLHEAVNGNIQLFQEKKMKLENGVNTKKTEEKIKQIEEDEINYLLDTIPFIKEYDVKETVSDVTEQNSVFQVKSKNTHTNTFRKYLFHVEKVSNPTTLDAVTDRETVDQIYTCTCGGQMELWVNSTQSDLVCNECGATQPYIETYSGKESNEGMAYKRINHLAECLNALQGKEGTNVPQEVINAVKAEFKKNRISTTSEIKPSKVKQFLKKLGYSMYYENIYTIANMISGIPTLKLSRELEKRLKDMFFEIQEPFFRHKPPKRKNFLSYNYVLYKFSELLGEDDLLQYFPLLKCPKNLHNQDVIWKKICNDLQWEFIATV
What is the function of this protein?
Putative transcription factor.
What are the official names of this protein?
Putative transcription factor A494R.
What is the protein family that this protein belongs to?
Belongs to the nucleo-cytoplasmic large DNA viruses (NCLDVs) VLTF-3 family.
Protein: FTSQ_RICBR
Sequence: MRKKTSSNKKNTAKKNNNISLHRKLGLIYKKTILILKIVLIIFICLFAFTKYFASLKSYLKTNIYQTTTELGFKLENVIIEGQQNVDEPTILKVLNAKKGSSIFALNLDEIRNNLKNNRWIKEVYVSRRLPSTIYIKLFEREPIAIWQINNQLFLIDEEGYEISKNIEPFPHLLHVVGEGANIYASKLVNELQKYPALINKTSSAIRCGDRRWDLNLKGGINIKLPAKNFEEALKYIDALNKANKLFNQNYKQLDLRDKNKYYIEKY
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.