PharMolix/UniProtQA huggingface dataset:
Protein: MSCL_STACT
Sequence: MFKEFKEFAFKGNVLDLAVAVVMGAAFNKIITSLVTYIIMPLIGLIFGTVDFAKNWSFMGIKYGLFVQSVIDFLIVAFALFLFVKLANTLMRKEEVEEEPEENIVLLTEIRDLLQQQNGTVTNETTNIFTETDDVDNKKF
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y270_SACD2
Sequence: MLYYSIVFLLIALVAGLFGFVGIAGVATGIAKILFFVFLIAFVVSLVIGRRPRV
What are the official names of this protein?
UPF0391 membrane protein Sde_0270.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SDHA_COXBU
Sequence: MSSIRVKQYDALIVGAGGAGLRAALEMAQSRQYKVAVVSKVFPTRSHTVSAQGGIAAALGNVVPDKPIWHMFDTVKGSDYLGDQDAIQYMCEQAPPSVYELEHYGLPFSRLDDGRIYQRAFGGHTRDFGKEMARRTCACADRTGHAMLHTLYQKNVEAGTHFYYEWYGIDLVRGAQGGIAGMIAMNMETSELVFFKSRATIFATGGAGRIYETTSNAYTNTGDGIGMVLRAGLPVQDMEFWQFHPTGIYGVGCLITEGARGEGGYLINKDGERFMERYSPHLKDLDCRDVVARSILQEVMAGGGVGPKKDHVLLKLDHLGEKVLRERLPGIIELSEKFANVDITKEPIPILPTCHYMMGGIPTNIHGQALTVDENGKDQIIEGLFAAGECACVSVHGANRLGTNSLLDLVVFGRAIGLHLEEALKTELKHRSENPDDIDAAIARLKRWEKPNNVENPALLRQEMRKAMSEDFGVFREEQKMKQGLERLQKLNERLQRAKLTDTSRTFNNARIEALELDNLMEVSYATAVSAQQRTESRGAHSRYDYKERDDANWLKHTVYFRDGHIAYRPVNMKPKGMDPFPPKSRD
What are the official names of this protein?
Succinate dehydrogenase flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL6_CLOK1
Sequence: MSRIGKLPIAIPAGVTFTVTPDNVVTVKGSKGQLVKAMAKDINIAVEDNSVVVTRNDDEKKSRSLHGLTRALINNMVVGVTEGYSKTLELIGVGYRAQLQGKKLVMNLGFSHPVEIEAVEGVTFETPAATKVVIKGIDKELVGNVAADIRSWRKPEPYKGKGIKYDNEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: 5NTD_HAEIN
Sequence: MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKLRKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSILYNKWKPYDIFTVDGEKIAIIGLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKVNDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMSSHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHDAKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPNKAGSNPEGSIATRFIAETMYNELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQFALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAYVAGGKDGYKTFGKLFNDPKYEGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDALPKK
What is the function of this protein?
Degrades NAD into adenosine and nicotinamide riboside, the latter being subsequently internalized by a specific permease.  Also endowed with NAD(P) pyrophosphatase activity.  Exhibits a broad substrate specificity, recognizing either mono- or dinucleotide nicotinamides and different adenosine phosphates with a maximal activity on 5'-adenosine monophosphate.
What are the official names of this protein?
NAD 5'-nucleotidase, NadN.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LEPA_CLOBL
Sequence: MQSERQKYIRNFSIVAHIDHGKSTLADRLIEATGTLTEREMDTQVLDNMDLEKERGITIKSQAVRLIYKRNTGEEYTLNLIDTPGHVDFNYEVSRSLAACEGAILVVDATQGIQAQTLANCYLALDNDLEIVPVINKIDLPSARPEEVKQEIEDVIGIEAEDAPLVSAKTGLNIKDALEAIVNKVPAPEGDEKAPLKALIFDSYYDSYKGVVCHIRVKEGTIKEGTEIKLMNTGKVYEVVEVGVFVPNYMPVDELKAGDVGYVTASIKNVRDARVGDTITEAKRSANEALSGYRPAVPMVFSGIYPVDGAKYEELKEALEKLQVNDAALSFEPETSIALGFGFRCGFLGLLHMDIIQERLEREFNLDIITTAPSVIYKITKTDGTLIELTNPTNMPSPSEIKLMEEPIVKSSIITPSDYVGAVMDLAQNRRGIFKDMQYLDTTRVSLNYEIPLNEIIYDFFDALKSRTRGYASFDYELIGYKDADLVKLDILLNADVVDALSMIVPRERAYAKGRNMAQKLKEIIPRQMFEIPIQAAVGAKIIARETIKAMRKDVLAKCYGGDISRKRKLLEKQKEGKKRMRQVGSVEVPQEAFMAVLKTEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SC11A_RAT
Sequence: MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMLITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQDGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFSYAVLFLLGLFVLVHRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18 kDa subunit, SPase 18 kDa subunit, SEC11 homolog A, SEC11-like protein 1, SPC18.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RPOZ_STRPQ
Sequence: MLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGATPTQEFKSVKSTLQALEEIESGNVVIHPDPSAKREAVRAKIEAERLAKEEEERKIKEQIAKEKEEEGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ACCA_PORPU
Sequence: MITSNRKPTVPDFMRPVAELESQVAELKRLAPKNDKVIENKINRFQDKLTKLQKEIFSSLTPLQRLNLVRQSERPTTLDYIPNILDEWIELHGDRGGADDPALVGGIGKIDGHSIVFIGHQRGRGTKENVARNFGMPAPGGYRKALRLMKHANRFGMPILTFIDTPGAWAGLKAEELGQGEAIAVNLREMFSFEVPIICTIIGEGGSGGALGIGIGDSIIMLEYAVYTVATPEACAAILWKNSKESLAAAEALKITSHDLKVMGIVDEILTEPIGGAQADHQSASKYLRKELIKQLNILLRLNKSELKIQRYEKFRKMGAFYEI
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PRHA_PENBI
Sequence: MAPMIPPRLQRFPATASADEIFAAFQEDGCVVIEGFISPEQVARFSQEVDPAMEKIPVEVTNNGNSNDRTKRFSKCVIASPTFRNEIIESDLMHELCDRVFSKPGEGMGYHFNDNMVIEVQPGAPAQRLHRDQELYPWWNSMGPAGPECVINFFCAVTPFTEENGATRLVPGSHLWPEFTQINERDCPQFGKIETVPAIMQPGDCYLMSGKVIHGAGHNATTTDRRRALALAIIRRELRPMQAFSLSVPMKLAREMSERSQTMFGFRSSVQHCDVDMVHFWGNDGKDIAHHLGLEAPSVHV
What is the function of this protein?
Multifunctional dioxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
Multifunctional dioxygenase prhA, Paraherquonin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: RINL_MOUSE
Sequence: MRLAQPDMVSAAPTEVDRLVWPLADGADKSPLGVLSTTEPLLRLQRTQRVWEVPELDAQYAKAFLELWPLGSFLVIGHEPGQVLMLKAGPSSGDINTYQIQRFPGGVSLESSNLCMPDCPHLLAFLSASRDVLPRTLLLPTPTVGAGDNHSDPHRLGCIQVDTSGRVLSVVNQLYLETHGGWGTETPQQTEPETGQKYSLAPRKPTPHRVSWVEDPLRPEAHHTGQEVHHPGADAHSLGSEVHFSCPALEEEEVNNDCYKDEDEEGCEDMLTAHIRALARTRSSYVARQYRCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQNYLAKDPDVRAVFGNRGPSILREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELRRLRRRQIALRVGAGPEGQSPALRNRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLGGGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWFGALYHIAHYQPDTGRAPQGLSSEARASLRQWHRRRTLHQQAQPTAQANQPFEEPWAIGDP
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP.  Plays a role in endocytosis via its role in activating Rab family members.
What are the official names of this protein?
Ras and Rab interactor-like protein.
What are the subcellular locations of this protein?
Cell projection, ruffle. Cytoplasmic vesicle.
Protein: SIRC_PRIMG
Sequence: MYTVMLDLKGRSVLVVGGGTIATRRIKGFLQEGAAITVVAPTVSAEINEWEAKGQLRVKRKKVGEEDLLNVFFIVVATNDQAVNKFVKQHIKNDQLVNMASSFSDGNIQIPAQFSRGRLSLAISTDGASPLLTKRIKEDLSSNYDESYTQYTQFLYECRVLIHRLNVSKSRKHELLTEIIDDQYRLSLVKQREFLQQIEKYK
What is the function of this protein?
Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin which is used as a precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis.  It is unable to oxidize precorrin-3.
What are the official names of this protein?
Precorrin-2 dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
Protein: RECR_NATTJ
Sequence: MSNYPKPINRLIEALSYLPGIGPKTAERLAFHIVSMDETKVNHLITALQDSRDKVFECSTCNNLTDKDPCTICQDESRDSNLICVVQDARDVTAIEKVQDFQGKYHVLQGVISPMEGIGPDDLNLKALMDRIQGEGITELVVATDPTVEGEATAMYLNKLVKPLGVRVTRLAYGLPMGGDLEYADEMTLQQAFEGRKEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: UVRC_PSEU2
Sequence: MTQTFDPGAFLATCSGRPGVYRMFDAEATLLYVGKAKNLKKRLASYFRKTGHAPKTGALVSRIAQIETTITGNETEALLLEQTLIKEWRPPYNILLRDDKSYPYVFLSDNAFPRLSIHRGTKKAKGRYFGPYPSAGAIRESLSLLQKTFQVRQCEDSYFKNRTRPCLQYQIKRCKGPCVGLVEPEVYAEDVRHSVMFLEGRSNALSDELNASMEKAAMALDFERAAELRDQVALLRRVQDQQSMDGGTGDVDVVAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVGEVMSAFLAQYFLGGIDRELPGEVIVNVINDDFPAFVDAVEELRGVEMVISHRVRGTRARWQQMAVTNAEQALTARLANRQHVASRFEALAKVLGLEDPPMRLECYDISHSSGEATVASCVVFGPEGPIKSDYRRFNIEGVTAGDDYAAMHQALTRRYSRIKAGEGKLPDVLLVDGGKGQMSMARDVLNELQVPELILLGVAKGTTRKAGFETLYLNDSAHEFTLPGDSPALHLIQQIRDEAHRFAITGHRARRGKTRRTSTLEGVAGVGPTRRRDLLKHFGGLQELSRASIDEIAKAPGISKKLAESIYANLHSE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VESPI_VESMG
Sequence: MHPIIWELSHMVDLQAAAQKLKRCYQRRVAITAGGLKHRLMSSLIIIIIIRINYLRDNSVIILESSY
What is the function of this protein?
Shows contractile activity on isolated ileum smooth muscle.
What are the official names of this protein?
Vespin.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRF_YERPP
Sequence: MTSATKTNNSGSISSPIVVALDYANKDAALAFADQVSPQDCRLKVGKEMFTLYGPELIRDLHQRGFDVFLDLKFHDIPNTTARAVAAAAELGVWMVNVHASGGARMMSAAKEALLPYGAQAPLLIAVTVLTSMDGEDLRDIGITISPAEQAERLAKLTWDCGLDGVVCSAHEAVRLKQVCGEDFSLVTPGIRPQGSEAGDQRRIMTPEQAVAVGVDYMVIGRPITQSPDPEKTLREILASLTKVA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: YECD_ECOLI
Sequence: MLELNAKTTALVVIDLQEGILPFAGGPHTADEVVNRAGKLAAKFRASGQPVFLVRVGWSADYAEALKQPVDAPSPAKVLPENWWQHPAALGATDSDIEIIKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHNNSINHIYPRIARVRSVEEILNAL
What are the official names of this protein?
Isochorismatase family protein YecD.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: ISPG_YERP3
Sequence: MHNGSPIIRRKSTRIYVGKVPIGDGAPIAVQSMTNTKTTDVDATVAQIKALERVGVDIVRVSIPTMDAAEAFKLIKQQSTVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNESRIREVVACARDYNIPIRIGINGGSLEKDIQEKYGEPTPEALLESAMRHVDILDRLNFDQFKVSVKASDVFLAVNSYRLLAKQINNPLHLGITEAGGARSGSVKSAIGLGLLLSEGIGDTLRISLAADPVEEVKVGFDILKSLRIRARGINFIACPTCSRQEFDVIGTVNALEQRLEDLITPMDVSIIGCVVNGPGEALVSTIGVTGARNHSGFYEDGVRQKERFDNKAMIDQLEAKIRAKASILDANNRIVINQLDDNK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HSYB_TOBAC
Sequence: MRALFLIYLILSPFRAVSRTLLENHEGLNVGSGYGRGTNLPPPSPASSPPSKEVSNSVSPTRTDEKTSENTELVMTTIAQGENSNQLFPFLTSSDNYQLASFKKLSISYLLPVSYVWKLISSSSFNHDLVDIFDTSSDEKYWNRKPLSPPSPKPADGHRPLQSY
What is the function of this protein?
Activates a lipid-based signal transduction pathway in which linolenic acid is converted to jasmonic acid, a potent activator of defense gene transcription, including proteinase inhibitors.
What are the official names of this protein?
Hydroxyproline-rich systemin B.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3G2_ENCCU
Sequence: MDISCEIEECKTREQQNSKRSAKACWGTVFSDLGALMSIALPMLMYFTFTKNDFDTSPLLKVVMLLFPCSYSAAGYFLLCYSSRTAHHKTGILYHLLNVLLVTFAAISILSIIVLPIEKWSKRLLGVYSMPSSSFVVSLTYLLYTSCDLTTASFTDTGITAFVELLSLLFLMSYPIFLTRNPEYYPYLSIISAILILARSFKEKYFPNKKTSESVVRWRLLIFFVILGFTTFSYIMAGLSCLHIIKEKCENFAGNQQILNK
What are the official names of this protein?
UPF0328 protein ECU03_1620.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: 3L2L_OXYSC
Sequence: RRCFITPNVRSERCPPGQEVCFTKTXDG
What is the function of this protein?
The heterotrimer blocks the voltage-dependent L-type calcium channels (Cav1/CACNA1) from the heart, and the small conductance calcium-activated potassium channels (KCa2/KCNN) in the chromaffin cells and in the brain.  Is very toxic to mice.
What are the official names of this protein?
Taicatoxin, alpha-neurotoxin-like component, TCX, alpha-neurotoxin-like component.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL13_SOLUE
Sequence: MSTEFPTKNGINREWHVIDAENVVLGKLASRAAMILMGKHKPTYTPFIDAGDHVVVINAEKVKVTGRKEEDKLYRHFTGYPGGLVEKSLKRVRAEKPTRIVEDAIAGMLPKNKLGKQMYRKLNVYAGSKHPHAAQQPVALTVK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: COBT_ALKMQ
Sequence: MNKLKETIRMIEELDQETMQKARERVDNLIKPPKSLGRLEDLAVQLAGITKTIHPTVANKAIIVMAADHGVYEEGIAGFPQEITVVQTLNFVKGVTGVCALGKVSGTKIIPVDIGVKEDLDPNAGVLIRKIKYGTDNMAKGPAMSREEAIRALEVGIEVANEEIKNGVTLLGTGEMGIGNTTASTAILSVLGNFDPKEITGRGAGLSPEGIQRKAAVIKRAIEVNQPDATDGIDVVAKVGGLEIAGMAGVMLAAAANRIPVVVDGYIATAAALIAVSLEPKTKQYLIPSHASAEIGSIKATELLGIKPMIHMDLCLGEGSGAALVFPIVEAACHMINCMPTFEEAGITI
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: CWC26_NEUCR
Sequence: MPSDKAAYLAAHYLSTDPPNKSSSSTSKKRKRKNKSAEDGLIIADDDDTSWAQAAKRDSDDDDFDGPVLAAGVVSADFRKAKKSGWKTVGSSSAFAKQATTSTTTNSTKEDIDAAAAADAILAQTAAETAALAREAGGDDEVLVVDTTTGATALTRSHQPAETATQAPIMSNGTHAGLQSASAITAQLKARQEAERLELERIRAERDQQHPEDQEELVLRDATGRRIDASMRRAEARRQQAEAERKEAEKKRALKGEVQLEQARRRREELEEAKLMPLARSKDDEQLNAELKQQDRWNDPMAQFLAPEEVKVKGRKKGTAGRRPTYKGPAPPNRYGIKPGYRWDGVDRSNGFEAERFKALNRRERNKGLEYAWQMDE
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor cwc-26.
What is the protein family that this protein belongs to?
Belongs to the CWC26 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PYRG_RHIE6
Sequence: MARYVFITGGVVSSLGKGIAAAALGALLQARGYRVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKDFVTEGNKDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAVYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHPDILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPMAYHKEGLDDEVLAAFGIEPAPKPRLDQWEEVCNRIRTPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGIANRVKVKLEWIESEVFEKEDPAPYLEKVHGILVPGGFGERGSEGKIHAARFARERKVPYFGICFGMQMAVIEAARNLADVPDASSTEFGPAKEPVVGLMTEWVKGNELQKRTAAGDLGGTMRLGAYKAALKKGTKISEIYGSTDISERHRHRYEVNIDYKDRLESCGLVFSGMSPDGVLPETIEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAATEQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: MMM1_ASHGO
Sequence: MKGVENTLSQSESVNRGYNGWMGMESETSARATHSSEQMISLEEYVREMLPMHLQKLLMERIIEAEQTGAAHTSVFAAPTGVAAQYPAMGPPMLPGQTFSSRSFAEGLVVGQLSVIVVLIFFIKFFIFSDGPAKTGGGGGSSAESRSSGFTGSPLTSTTSRLLSTLIKRGGKEGTEFAEDSENERTRQINAILEKTYYDVETHSPESLDWFNVLIAQTIQKFREEALQKDNIVHSLNDFISRKSSQLPNYLDAVKITELDIGDDFPIFSNCRIKYSPPLNKKRLEAKIDIDLSDRLTLGIETRLLMNYPKYLTASLPVKLTVSMLRFQACLTVSLTTAEEFVPTMAATTDTDAGDSEGHYLVFSFSPDYRMEFDIKSLIGARSKLENIPKISSLVEYQIKKWFMDRCVEPRFQFVKLPSMWPRSKNTREEKSDMQEEDPSRAPE
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: PPIA_MYCTO
Sequence: MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVGLAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAISKTATDGNDRPTDPVVIESITIS
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANKY_MOUSE
Sequence: MSEALPFPSNKTSTPECNLKTLYWACVHNDLAELQARLDAGVSPEEASQVDSNGRTGLMVACYHGFGSIVALLSCCPFLDVNQQDKDGNTALMLAAQAGHMSLVTLLLNYFAGLDLERRDQRGLTALMKAAIQDRSECVVALLMAGADLSSVDPVRGKTALEWAVLTDSFDTAQKIRQLLRRPQAEQLSLHYQPEWPALAQLVAQAQAQAQAPAAPSLLERLQATLSLSFAQSPQEGGVLDHLVTVTTSLASPFLSTACHTLCPDHPPKLGTRGKSVPELLGTAPPPPPEPHPPQQVPVPQVFAPNQSPQSMFSQWLQSRDSTRSQVPKILLSKAPSPSARYELTLRPQGQQSLAPPVWRFQERKKKEEETEPRGGGLGQAGGSK
What is the function of this protein?
Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.
What are the official names of this protein?
Photoreceptor ankyrin repeat protein, Ankyrin repeat domain-containing protein 33.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm, cytosol. Nucleus.