PharMolix/UniProtQA huggingface dataset:
Protein: ZN185_HUMAN
Sequence: MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLLDQIFIHRDTIHCGKCYEKLF
What is the function of this protein?
May be involved in the regulation of cellular proliferation and/or differentiation.
What are the official names of this protein?
Zinc finger protein 185, LIM domain protein ZNF185, P1-A.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
Protein: ATPB_CUCSA
Sequence: MRINPTTSSPEVSTLEKNNLGRIAQIIGPVLDVAFPPGKMPNIYNALIVKGQDISGQEINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVVDTRAPLSVPVGGATLGRIFNVLGEPIDNLGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEENFAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGNIDEATAKATNLEMESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TOM5_ARATH
Sequence: MVNNVVSIEKMKALWHSEVHDEQKWAVNMKLLRALGMFAGGVVLMRSYGDLMGV
What is the function of this protein?
A component of the complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM5 homolog, Translocase of outer membrane 5 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom5 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: HIS1_HALWD
Sequence: MRIAVPNKGRLHDPSVTLLERAGLHVEGAAERKLYADTVDPDVRLLFARAADIPQYVRDGAAAVGITGRDQVIESGCDLIELVDLEFGRCQLVLAAPEDGALSSPADVAGGSVATEFPRVTRQYLKDNAVDAEIVEVTGATELTPHVEMADAIVDITSTGTTLRMNGLTVIDEVLESSVRLYAHPERVDDSKVEQLVTAFNSVLAAEGKRYLMMNAPQDRLDAVREVIPGLGGPTVMDVAGEDTVAVHVVVDERDVFEIVSKLKTVGASGILVTEIERLVE
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMI_COLP3
Sequence: MSARISLNVGREKSLLRKHPWIFSKAVNKIKGNPMLGDTVDVFDSKGNWLAKGAYSPESQIRIRVWSFDEHEEIDRDFFFAKLQSAQARRDWFISQGKLTGYRLIAGESDGLPGVTIDKYDNFIVCQLLSAGADFHRYTIVNCLTELYPGCHIYERSDVDVRKKEGLEPVTGWLTEPQDSTECIIEEHGIKIHVDIATGHKTGFYLDQRDSRLAAGKFAKDKTVLNCFSYTSTFALHCAANNAKEVINVDVSQDALDMGERNLALNGLSDANVSFVKEDVFKLLRRYREEKRTFDMIILDPPKFVESKAQLTGACRGYKDINMIAMQLLNPGGLLLTFSCSGLMEASLFQKVVADAALDAKRKAYFVERLQQAADHPISSNYPEGYYLKGLVCQVE
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_ESCF3
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKDRESAEPEELVEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDHQFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVPWWVTLARHNLEREAPNGVATEMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSKLDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEFFAATIESKAKLVYDEVSDWLENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKIGFGIYNVHMGFDPANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_STAAN
Sequence: MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDVEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYIE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_NOCFA
Sequence: MAETALPTRAEVAARIDHTLLAPEATDDDVAALVAEARDLGVYAVCVSPSMLPVRAPGLVVATVAGFPSGKHHSLVKGAEARLAVDQGAAEVDMVIDVGAARAGEYSAVLADIVTVREAISDRAVLKVIIESAALSDEAIVEVCRVAERAGADFVKTSTGFHPAGGASVHAVRLMAETVGGRLGIKASGGIRTAAAAAELLAAGATRLGLSKSAAVLDGFPS
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_SULIN
Sequence: MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGIIPLHTKDAVKDADIIVFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIEPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDVSGTALQKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVDLVYEKGITGMVKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSQVQNSLEEKIGNQLKDLIQKGKPKKS
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TRA1_MYCTU
Sequence: MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTSTEEPAKQQTTNTPALTT
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS1081.
What is the protein family that this protein belongs to?
Belongs to the transposase mutator family.
Protein: GLPE_PSET1
Sequence: MAFKHISIAQTLELLDKEDVVIADIRDPNSYQAGHIPGSEALSNANIAHFMMEKEFDQPIIIVCYHGMSSQGAASYLVEQGFEDVYSMDGGFTAWEAAYSEKVER
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_OENOB
Sequence: MSKNIVMLGLPGVGKGTNADIMVEDFKLPHISTGDIFRSAMANHTELGDKAKSFMDAGNLVPDEITNGIVNERLNEADVKDAGGFILDGYPRNTSQADSLESFLRSIQQKLNAVIYLDASEKTVTNRMLGRGREDDTPEVVAHRIDVAKKETMPLVEYYRNKGSLYTIDANGEVSVVYPKIKKLVSNL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHP1_YEAST
Sequence: MSDLVNKKFPAGDYKFQYIAISQSDADSESCKMPQTVEWSKLISENKKVIITGAPAAFSPTCTVSHIPGYINYLDELVKEKEVDQVIVVTVDNPFANQAWAKSLGVKDTTHIKFASDPGCAFTKSIGFELAVGDGVYWSGRWAMVVENGIVTYAAKETNPGTDVTVSSVESVLAHL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.  Preferentially eliminates organic peroxides rather than hydrogen peroxide (PubMed:10391912, PubMed:9988687, PubMed:10681558).  Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation (PubMed:20145245).  Involved in cellular Mn(2+) homeostasis (PubMed:10635552).
What are the official names of this protein?
Peroxiredoxin AHP1, Prx, Alkyl hydroperoxide reductase, AHPC1, Cytoplasmic thiol peroxidase 3, cTPx 3, Thiol-specific antioxidant II, TSA II, Thioredoxin peroxidase type II, TPx type II, Thioredoxin-dependent peroxiredoxin AHP1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_DSDNV
Sequence: MSFYARALTHRARPGYRIIPENTVTEDIELGAIGEETPLLSEGIITAAEETAAVGLPELGVGAVGAVGTHADVLYRNRNAFKSVLTGNYTDLKGNPLKQRNAISEKTKQLGKQIFQGDFNRAFPDNLKLETEQEKTDLLRYYNHNRRLAGLSEAYPQGKGYAYAKSQKVLEAEKRGLTVPGYKYLGPGNSLNRGPPTNEIDADAKEHDEAYSQSKTAQEVSKADNTFVNKALDHVVNAINLKESPSNTVGAIIGATGIGTKQAIEKHTGVIYPSVSGMSREINPKYLNSWSDWIKENKPNNFAGIQLPEDFYTEEQTLSDSPMSESTKRKADTPAEETPSKKGAHNTDSSSQSADPQNPSSSGATTDLDVTMAMSLPGTGSGTSSGGGNTTGQEIYEIPRPFTNFGKKLSTYTKSHKFMIFGLANNVIAETGTTGNLHRLLTTCLAEIPWQKIPLYMNQSEFDLLPPGSRIVECNVKVIFRSNRIAFETSSTATKQATLNQISNLQTAVGLNKLGWGIDRSFTAFQSDQPMIPTASAPPKYASVSGANGYRGMIADYYGADSNNDIAFGNAGNYPHHQVGSFTFLQNYYCMYIQTERGTGGWPCLAEHFQQYDSKTVNNQCLLDVSYKPQMGMIKPPLNYNIIGFPTNKGAISIGENLTAMRSANVSGPEIATQQVSETSNNRIHNFPATFFDIYADIEKSQRLNKGPWGFEHPQIQPSIHIGMQAVPALTTGALLVNSSPLNSWTDSMGYVDVIASCTVMESQPTHFPYATSANTNPGNTVYRNNINVNSLTSAFNGLYGNAATLGSL
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA.  Capsid proteins are responsible for the attachment to host cell receptors.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).
What are the official names of this protein?
Capsid protein VP1, Coat protein VP1, Structural protein VP1.
What are the subcellular locations of this protein?
Virion.
Protein: HUB1_KLULA
Sequence: MIEVLVNDRLGKKVNVKCLSEDTVGDFKKVLSVQLGTASASKIVLQKGGSVLKDHITLEDYEVHDGTNLELYYV
What are the official names of this protein?
Ubiquitin-like modifier HUB1.
Protein: RIMO_PROMP
Sequence: MKQNNQNVKDKKISKVAFSHVGCEKNLVDTEHMQGLLDKEGYEVGNDIEDANVVVVNTCSFIETAREESIRKIIEFTDQGKEVIVAGCMAQHFKEELLKEMPEIKGLVGTGDYQKIAKVIKRVEKGEIVNEVSKIPEFIADEKIPRFVDKNKFVAYLRIAEGCDYKCAFCIIPKLRGPQRSRDIESIVSEAKNLAAQGIQEIILISQITTNYGQDIYGKPSLARLLKELSKVSVPWIRIHYAYPTGLTDEVIKSFKDSNNIVPYFDLPLQHSHPDVLKSMNRPWQASLNESILSQIREQIPSAVLRTSLIVGFPGENQKHFQHLLDFLHRHEFDHVGVFIFSPEEGTSAFDLPNRVPSEVADARKDNIISIQQNISKKKNQLYVGTTIKVLVEKISENKELIGRSYNFAPEIDGNVILSIKNYEDEKNYIGKFVEANICFADEYDLYGEVIKTL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTPG4_ARATH
Sequence: MKQSLLLSFVLLLLSSSSLVTPIHARNKSNPAKSPVGAPAPGPSSSDCSTVIYSMMDCLGYLGVGSNETKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIELNSTRALATPKACKLSIAPPHCGIITSGATTPGASPVSPSAGAPTTSPSAAKSPETSATSPSSDETPSMTAPSPSSSGTNILSVPALTIVFVIVSSVAYISAFSN
What is the function of this protein?
Lipid transfer protein involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition.
What are the official names of this protein?
Non-specific lipid transfer protein GPI-anchored 4, AtLTPG-4, Protein LTP-GPI-ANCHORED 4, Xylogen like protein 3, AtXYLP3, AtXYP3.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: RBMS1_RAT
Sequence: MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKATNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRVLRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWPREGEAGMTLTYDPTTAALHNGFYPSPYSIATNRMITQTSLTPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTATVPVEEASGQQQVTVETSNDHSPYTFPPNK
What is the function of this protein?
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene.  Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'.  Probably has a role in DNA replication (By similarity).
What are the official names of this protein?
RNA-binding motif, single-stranded-interacting protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: VDRA_DANRE
Sequence: MLTENSAVNSGGKSKCEAGACESRVNGDATSVMDLMAVSTSATGQDEFDRNAPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCIDIGMMKEFILTDEEVQRKKDLIMKRKEEEAAREARKPRLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVREGPVTRSASRAASLHSLSDASSDSFNHSPESVDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEVS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes.  Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association.  Plays a central role in calcium homeostasis.
What are the official names of this protein?
Vitamin D3 receptor A, VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4.
Protein: PSAE_CHLRE
Sequence: MQALSSRVNIAAKPQRAQRLVVRAEEVKAAPKKEVGPKRGSLVKILRPESYWFNQVGKVVSVDQSGVRYPVVVRFENQNYAGVTTNNYALDEVVAAK
What is the function of this protein?
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
What are the official names of this protein?
Photosystem I reaction center subunit IV, chloroplastic, PSI-E, P30 protein, Photosystem I 8.1 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsaE family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SI1L3_HUMAN
Sequence: MTTYRAIPSDGVDLAASCGARVGDVLPGPHTGDYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREALREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQDGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQGMPEQSFFDILNEFRSEQPDARGCQALTELLRADPGPHLMGGGGGAKGDSHNGQPAKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIFCREKKEL
What is the function of this protein?
Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).
What are the official names of this protein?
Signal-induced proliferation-associated 1-like protein 3, SIPA1-like protein 3, SPA-1-like protein 3.
What are the subcellular locations of this protein?
Apical cell membrane. Note=Detected in tricellular junctions. Colocalizes with apical F-actin.
Protein: HBB_HUMAN
Sequence: MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: VPR_HV2CA
Sequence: MTEAPTELPPEDGTPPREPGDEWVIEILRDIKEEALKHFDPRLLTALGGHIYARHGDTLERARELIRVLQRALFTHFRAGCNHSRIGQTRGGNPLSAIPTPRRM
What is the function of this protein?
Stimulates gene expression driven by the HIV-2 LTR.  Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle.  Cell cycle arrest creates a favorable environment for maximizing viral expression and production (By similarity).
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: TSGA_SALSV
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFQLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKTQLRFGFILMVLAVAGLMFSHSLALFSAAMFVLGLVSGITMSIGTFLITQLYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYACIGLVYLAIFILTFGCEFPALGKHAQHSQAPVAKEKWGIGVLFLAVAALCYILGQLGFISWVPEYAKGLGMSLNDAGALVSDFWMSYMFGMWAFSFILRFFDLQRILTVLAGIAAVLMYLFITGTQAHMPWFILTLGFFSSAIYTSIITLGSQQTKVASPKLVNFILTCGTIGTMLTFVVTGPIVAHSGPQAALLTANGLYAVVFVMCFALGFVSRHRQHSSPAAH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRC_CLOK5
Sequence: MFDFEQQLKILPDKPGVYLMKNSLGEVIYVGKAKILKNRVRQYFQKSKNHSEKVRTMVKHISEFEYIVTDSEMEALVLECNLIKKYRPRYNILLKDDKIYPLIKITLNEDFPRIICARNKIKDGAKYFGPYISTGAVYETMEVIKKIFPIRDCKLNIKKGNVKVRPCLNYHIGLCKAPCTGHISKEEYGKIISGVMDFLSGKNKDIIRKLKEDMDTLSENMEFEKAAELRDKIFALEKIIEKQKITTGGFEDEDFINIHSDEKDSCIQVFFSRTGKIIGREHFIIEDTQDLPKGEIVANFIKEFYGGTAYIAKTIYVPEIYDVQLLEDWLSIKKDSKVYIKIPQKGDKKAILNLVEKNARTTLQNFKLKFIQDKKMYETSLEELMEILNLDDIPHRIEAYDVSNIQGVDSVGTMVVFENGRPKHNDYRRFKINEVKGANDYESMKEILRRRFQNGMEEIKRIKERKLEFSAGKFSFFPDLILMDGGKIQVSAALEVLKEFNIDITVCGMVKDDKHRTRGLIYRNEEMPLNRNSNIIKLITRIQDEVHRFAVTYHRSLRSKRVLHSVLEDIPNVGVKRRKELLKRFLSVENIKKASMEELISTPSIDMRTAESIISYFRGYKS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.