PharMolix/UniProtQA huggingface dataset:
Protein: SYNPO_HUMAN
Sequence: MLGPHLPPPPLAPSEGRPTPCAFQIPDGSYRCLALEAEESSGEEGLQGEVGPTDLEEDEGVSRSGDDSACRVTQGTPQLPKALGIQPPSCSREEQGASQHDDRASQDWDVVKAGQMMTASPSPGPGPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESHGQRGQKPSQESLRVLPSSLPGHAPGLSLSSTSLPEPGPPRHPSPQSPDRGVPGHSMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK
What is the function of this protein?
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes.  Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).
What are the official names of this protein?
Synaptopodin.
What is the protein family that this protein belongs to?
Belongs to the synaptopodin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Postsynaptic density. Synapse. Cytoplasm, cytosol. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses.
Protein: Y586_PYRAE
Sequence: MLVEEVLLLLVAIALISAFALTVTGVVQNAVSQILGFRNATNNVINGLVDAVKQLIGLS
What are the official names of this protein?
Uncharacterized protein PAE0586/PAE2015.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PETL_PSINU
Sequence: MLTLLSYFGLLLAALISTLVLFIGLNKVKLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DDL_YERP3
Sequence: MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPH_ORYSI
Sequence: MNPLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ATPD_CHLPM
Sequence: MSSVIASRRYAYAFLSAAEAGGFLETVTGEMQMVGETLAASRDLQRALASPLINADRKTHLLEEIFAEAVGDKMMLFLRLIAHKKRAGILGGITQEFAALLDEKNGIVNAAVTSATELSDSQQKALSRSLEGYTGKKVRSAMKIDESLIGGLSVKIGDTIFDGSVRHQLQLLREKLVAVEA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FRP_SYNY3
Sequence: MLQTAEAPWSQAETQSAHALFRKAYQRELDGLLATVQAQASQITQIDDLWKLHDFLSAKRHEIDGKYDDRQSVIIFVFAQLLKEGLVQAEELTFLAADKQSKIKALARL
What is the function of this protein?
Destabilizes orange carotenoid protein-R form (OCP-R), the FRP-OCP interaction accelerates the OCP-R to OCP-O conversion (PubMed:20534537, PubMed:23716688).  Increases fluorescence recovery following non-photochemical quenching (NPQ) by OCP, most probably by destabilizing OCP-R binding to the phycobilisome core (PubMed:21764991).
What are the official names of this protein?
Fluorescence recovery protein, FRP.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Very tightly associated with the membrane.
Protein: Y698_STRPS
Sequence: MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVPTQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR
What are the official names of this protein?
UPF0298 protein SPCG_0698.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_DELAS
Sequence: MQVILLDKVVNLGGLGDIVKVKDGYARNFLIPTGAARRATASAKAEFEAKRVELEKQAAEKLAAAQQLGEKLNGVNVKLTQKAGVDGRLFGSVTNADIAEELTKAGFAVAKSQVRLVNGPIKTVGDATVVVALHTDVSVEVTVSVYGDHS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PROD_BOVIN
Sequence: MGLRRTSWMHFSALCRRAPLSTAPAAREQPAAGPGAEPVCGPAETARPPVPAVDFGNTQEAYRSRRSWELARSLLVLSLCASPALLARHEQLLHLARKLLGQRLFNTLMKMTFYGQFVAGEDQESIRPLIQHNRAFGVGSILDYGVEEDLTPEEAERTEMESCSSALERDGCGVSKREKQFQAHRAFGDRRDGVTSARTYFYASEAKCDSHMETFLHCIEASGGASEDGFSAIKLTALGRPQFLLQFSDMLTKWRRFFHHVAAEQGKAGLAAVDTKLEVAALQESVVKMGIASRAEIEDWFTAETLGVSGTLDLLDWCSLIDSRTELSRHLVVPNMQTGRLEPLLSQFTEEEERQMTRMLQRMDVLAKKANQVGVRLMVDAEQTYFQPAISRLTLEMQRRFNVERPLIFNTFQCYLRDAYDNVILDVELARREGWCFGAKLVRGAYMAQVGYEDPINPTYEATSAVYHRCLDYVLEELKHNARAAVMVASHNEDTVRFTLRRMEELGLHPADRQVYFGQLLGMCDHISFPLGQAGFPVYKYVPYGPVMEVLPYLSRRALENSGVMKGAQRERQLLWQELKRRLCTRSLFHQPA
What is the function of this protein?
Converts proline to delta-1-pyrroline-5-carboxylate.
What are the official names of this protein?
Proline dehydrogenase 1, mitochondrial, Proline oxidase.
What is the protein family that this protein belongs to?
Belongs to the proline oxidase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EFG_POLAQ
Sequence: MARKTPIDKYRNIGISAHIDAGKTTTTERVLFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTTFWKGMAGNFPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYQVPRLAFVNKMDRTGANFFKVYDQMKLRLKANPILIQIPIGAEENFKGVVDLVKMKAIYWDEASQGTKFSYEEIPAELKASAEEWREKMVEAAAESSEELMEKYLGGEELTEEEIKAALRQRTIANEIIPMMCGTAFKNKGVQAMLDAVVELLPSPLDVPPVPCELEDGTPTTRKADDAEKFSALAFKIMTDPFVGQLIFFRVYSGVMKSGDTIYNPIKGKKERVGRLLQMHANQREEIKEVYAGDIAAAVGLKDATTGETLCDPDSIVILERMVFPEPVISQAVEPKTKPDQEKMGLALNRLAQEDPSFRVKTDEESGQTIISGMGELHLEILVDRMRREFGVEATVGKPQVAYRETIRKVCEEIEGKFVKQSGGRGQYGHVVLKLEPQEPGKGFEFIDAIKGGVVPREYIPAVEKGIRETLNSGILAGYPVVDIKATLFFGSYHDVDSNENAFKMAGSMAFKDGMRKASPVLLEPMMAVEVETPEDFMGNVMGDLSSRRGILQGMDDIPGGGKIVRAEVPLAEMFGYSTGLRSLTQGRATYTMEFKHYSEAPKNVAEAVMAAKAK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_STRSV
Sequence: MKITKIEKKKRLYLLELDDSEKLYITEDTIVRFMLSKGMEITEQELSEIQDYAQFSYGKNLALYHLSFKQRTAKEVKDFLTQHDIQPEIISQVLDNLKKDNWINDRKYAHSFIQSNLLTGDKGAFVLKQKLSQKGISSTIIEEELSQFDFTELTNKVAEKLLKKYQEKLPSKALQDKILQSLINKGFSYSQAKTAYQHLEIEEDQENQQELLYKELDKQYRKYSKKYDGYDLKQRLTQALARKGYDFSDIASALREYL
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_CUPTR
Sequence: MPTDLHAWNALLRHHDTLRDAQMRDWFDREGAQRVAQCSLEAAGLYLDYSKNRITPQTMSLLMQLAAEAGVTRRRDAMFAGEHINTTEDRAVLHVALRAPAGAAFKVDGEAVVPAIHQVLARMRDFSARVRSGAWKGATGERITDVINIGIGGSDLGPRMVCRALSHLADADGHAAPRMHFVSNVDGTDLAETLVRLDPQRTLVIVCSKTFTTLETMANARSARAWFVASGVAEQDLAKHFVAVSTNTEAVREFGIDPANMFEFWDWIGGRFSLWSSVGLSITLAVGFDAFSDLLAGGHAMDEHFRTAPLERNMPVILGMLGVWYRNFWNLPTSCMAPYSTSLELFPAFLQQLEMESNGKSVQLDGQRIRTHTSPVVWGTAGTNGQHAYFQQIHQGSQVVPVDFVAPLVPPRRLPGHHAKLLANCFAQAEALMRGRSADELRASGLKDEVRIAHMVFDGNRPSNTLLMEDLTPNVLGALIALYEHRTFVQGVVWRINSFDQWGVELGKILARPIEAELTGTATGQHDASTAALIARARAVLKAGAAS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_PSELT
Sequence: MPDTIVAISTPIGTGAISVIRMSGSKSWQICQNVLLRKTKIEPRKAFHNYVKDSDGTILDEVMVIFYKSPNSYTGEDMIEIMCHGGIAVTQSILDTLISHGARPAEPGEFTRRAFLNGKIDLTKAEAVKQIIEASSRKTVKLVAANLAGRLSEIVHKLRETLLGTLAKIEVEFDYPDEILTDPYLIEKELNDAILQIEEILKNAQNRLILSSGIKVVIIGKPNVGKSTLLNTLVKEERAIVTDIPGTTRDLIEVPLMINGISFTLIDTAGIRHSHDEVEKIGVERAIKAADEGNLILFVLDATTPVDENDKKILSLIKEKKYIVVINKIDATDLIDREELKKILGTNTHVLTISALKKEGIQRLEEEIIKSVKDLIQQTDGYITTQRQYEYLASCRKELSDSIEAFKKKLPLDIVAQKVKEALGSIDKLLGTDYTDDLLDRIFKDFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQEK_ECOLI
Sequence: MDIEFSQIHEMVYMHDIVNSDSKKKPRIPLKKFLNAENVLTQTTSWTLNSRYVNVNSVNKVNVKSKVKNSYISRSVNDEFSLTDDEINSFKETLVLSSIDSLSKLVLNNPLSVLFTSTVRRNNNRAKMNVEFDSWICTRCC
What are the official names of this protein?
Uncharacterized protein YqeK.
Protein: OSTC1_DIPSG
Sequence: AAGQLSLTQLESLREVCELNLACEHMMDTEGIIAAYTAYYGPIPY
What is the function of this protein?
Binds strongly to apatite and calcium.
What are the official names of this protein?
Osteocalcin 1, DsaOC1, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: YACG_ECO57
Sequence: MSETITVNCPTCGKTVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEEPKQ
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: PRIB_LENED
Sequence: MEVHAEQLQKPPVVRGARACTTCRAAKMKCVGAEDGQRQCQRCKRANVQCIFEKHRRGRKPGSKLSEASKMLRRLEKGLNSAKSKAFSIDARHSSSYRDSHPSLGEPDDRYTNGVRSHPYSPPNGQFVSNLPPLNLPSYPDAASEYTASSTSSRTLDANDDEGDSASDRAEDNIFPANFIQRERRRNSFFRTILNPEDAPASGPSSVRCSETYSPPQSPAAPAGLNDPVSAGIVDEEHAKVLFDLIFLRLNPFINLFDPSLHTVSYVRNKSPFLFTVLIMAGCKFFRPELFKQCQKLADEYAVQAFACLTYWKGHDDNRTSTWTFVGYACRMRVEIGLNRYVPNVPSNETELQRLERRNRERTYLVLFIHDRSLSTQTGRHWMLPEDDFIRHSDRWHESSGGSVRPEDVIVAAFVQLRHIAAETTEIFQRGVDMSSEVVLRSCNSQLTQWNETWHREMQQAGGGAFHFSFLSLFRLYVRLFTNSLALRESSNRATPNIQALSACYTSAVDSLKVVSEFARMNVLRYGQETITMMSAYAALYLLSLLRNTLRYCSCTMAQLKMRIL
What are the official names of this protein?
Protein priB.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR7_XANAC
Sequence: MPVSTTLLQSDLPGLPLRHRGKVRDVFDIPRDRLPADAPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFHKTEHLMPNHLVDIRVEQVLPEGVDPALYAKRAVVTRKLKPVPVEAIARGYVIGSGWKDYQRTGKISGIELPDGLRQAEKLPEPIFTPSTKAAVGDHDENIDFDAMVKTVGAELAERVRDATLRIYRFAADFAAERGILLADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADQYEPGTSPPSYDKQFVRDYLETLDWGKTAPGPRLPADVIDRTRAKYAEALQRLAGISVD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: UTP15_PONAB
Sequence: MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQESIKTFSRFKDTAYCATFRQDGRLIVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEVLTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVCDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLENTSDGFPENKKIES
What is the function of this protein?
Ribosome biogenesis factor.  Involved in nucleolar processing of pre-18S ribosomal RNA.  Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 15 homolog.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Found predominantly at the fibrillar center.
Protein: G3P1_YEAST
Sequence: MIRIAINGFGRIGRLVLRLALQRKDIEVVAVNDPFISNDYAAYMVKYDSTHGRYKGTVSHDDKHIIIDGVKIATYQERDPANLPWGSLKIDVAVDSTGVFKELDTAQKHIDAGAKKVVITAPSSSAPMFVVGVNHTKYTPDKKIVSNASCTTNCLAPLAKVINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLEKEATYDQIKKAVKAAAEGPMKGVLGYTEDAVVSSDFLGDTHASIFDASAGIQLSPKFVKLISWYDNEYGYSARVVDLIEYVAKA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, GAPDH 1.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TACY_LISM2
Sequence: MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Acts as major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Listeriolysin O, LLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host membrane and forms pores formed by transmembrane beta-strands.
Protein: RSSA_ANOGA
Sequence: MSGNLDVLSLKEDDVTKMLAATTHIGSTSVNFQMEQYVYKRRTDGVHIINLGRTYEKLLLAARCIASIEYPGEVFAISSRPYGQRAVLKYAHYTQATPIAGRFTPGAFTNQIQTTFREPRLLIVTDPLTDHQPVTEASYVNIPVIAFCNTDSPVKFVDIAIPCNTKSTHSIGLMWWMLAREVLRLRGKITHDRWEVMPDLFFFRDPEEAEKEQAAIEAAAPVIKDVPDEVVVADEPTTWGEDVTQTAMAVPQAKPLAVAGANDDWNEDDTAPAAPGAASWGGAAF
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein SA.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_SHEHH
Sequence: MNQSLLAPYGNAIERVNAALTALRQGKGVLVVDDEDRENEGDLIYSAETLTNEQMALLIRECSGIVCLCLTDERIEQLQLPPMVSDNNSQYGTAFTVSIEAKQGVTTGVSAADRVTTIKTAIADNAKPDDLARPGHVYPLRARPGGVLERRGHTEGTVDLMKLAGLKPYGVLCEVTLVDGTMARLPEIIEFGQQHDMPVLTIEDIVAYRTTQ
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: HBB_SHEEP
Sequence: MLTAEEKAAVTGFWGKVKVDEVGAEALGRLLVVYPWTQRFFEHFGDLSNADAVMNNPKVKAHGKKVLDSFSNGMKHLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVVVLARHHGNEFTPVLQADFQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TWST1_MICMU
Sequence: MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGAGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
What is the function of this protein?
Acts as a transcriptional regulator.  Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.  This interaction probably involves the basic domains of both proteins.  Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B.  Regulates cranial suture patterning and fusion.  Activates transcription as a heterodimer with E proteins.  Regulates gene expression differentially, depending on dimer composition.  Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression.  Heterodimerization is also required for osteoblast differentiation.  Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity).
What are the official names of this protein?
Twist-related protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: YPTA_BACSU
Sequence: MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAVEHIYSTDHPFLSSHVINRK
What are the official names of this protein?
Uncharacterized protein YptA.
Protein: CNJC_TETTH
Sequence: MEGIKLTLTNLEEFKCEFTLENCDISLANSLRRILLAEIETIAIHNVKVYENTSSLPDEYIAHRLGLIPLNSAKVDDYNYIWNCNCQGECDRCTIHFDLRVSNFTNEVLEVTSLDLKQRQDHTDEDAVRPIKVYSILRDEYGNKREVGIPIIKLSKGQQIHFECEAQKGIGKMHSKWNPVCISTFSVEPEIIFDQEIQNLDIEQKKALVNACPTKVFGINPHTNTLEVQDHMKCMYCEECVYKCAEDFQKPKLIKIDHKKDKFFFKVETTGVMKPVEVLRRGFSTLRQKLDFMREQIQENSNNQFEYGNE
What is the function of this protein?
May be a stage-specific RNA polymerase subunit.
What are the official names of this protein?
Conjugation stage-specific protein.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CADM3_HUMAN
Sequence: MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
What is the function of this protein?
Involved in the cell-cell adhesion.  Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3.  Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
What are the official names of this protein?
Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, IgSF4B, Nectin-like protein 1, NECL-1, Synaptic cell adhesion molecule 3, SynCAM3, TSLC1-like protein 1, TSLL1.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction.
Protein: RL6_MYCPN
Sequence: MSKIGNRTITLDPAKVNLNFQKDHIAVKGPLGQIELKLPPNLPLKFELKDNNLQITRNNELKQSKIFHGTYNALITNAIIGVTQGFEKKLRLVGVGYRANVEGETLNLQLGYSHPIKEKIPKGLTVKVEKNTEITISGISKELVGQFATEVRKWRKPEPYKGKGVLYFDEVIVRKAGKTAEGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.