PharMolix/UniProtQA huggingface dataset:
Protein: RL22_FRAAA
Sequence: MADDLVEGLTRAGLPGAKASARYVRVSPTKARRVVDLVRGRSVSEALDILRFAPQAASDDVYKVVASAAANAENNHSLDPATLWVGEVYVDEGPTLKRIRPRAQGRAYRIRKRTSHITVVVESREPVSAAGRGAKTTRRAR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DAPE_SHEAM
Sequence: MSSPETHSDVIELTRELISRPSVTPLDEGCQDLMAKRLAAIGFTIEPMVFEDTTNLWARRGTEGPVFCFAGHTDVVPVGDLNRWHTPPFDPVVIDGYIHGRGAADMKGSLAAMVVAAERFVAEHPDHQGSIAFLITSDEEGPFINGTVRVVETLEARHEKITWALVGEPSSTHLLGDVVKNGRRGSLTGNLTVKGIQGHVAYPHLADNPIHRAAPALAELSRIEWDKGNEFFPPTSFQIANINGGTGASNVIPGELKVMFNFRYSTEVTAETLIARVLGILDAHGLDYDIDWVFNGLPFLTGEGPLLDATREAIFEVTGTHTDPQTTGGTSDGRFIAPTGAQVIELGPVNATIHKVNECVKASDLELLTGCYQRILEKLLCN
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: SC11C_PONAB
Sequence: MVRAGAVGAHLPASGLDIFGDLKKMNKRQLYYQVLNFAMIVSSALMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11C, Microsomal signal peptidase 21 kDa subunit, SPase 21 kDa subunit, SEC11 homolog C, SEC11-like protein 3, SPC21.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: YBEY_RICB8
Sequence: MINVEIIKNYSKWREHKQINKALIKKITQKTLSQFDNFSEIKQFELSILLTNNEEILTLNKQFRNIEKATNVLSFPANELNWQDLRFSGNEIASSNKPIILENLGDSDYMHLGDIAFCYDVIYNESYEQQKTFENHFIHLLIHSILHLIGFDHQNDTETKIMENLEIEILAHFGISSPYLLIK
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEM4D_CHICK
Sequence: DDKIYFFFTEVSVEYEFVGKLMIPRIARVCKRDQGGLRTLQKKWTSFLKARLICTIPDKNLIFNIINDVFTLKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSAVEEVFSKGKYMQSATVEQSHTKWVRYNGEIPNPRPGACINNEARALNYVTSLNLPDKTLQFVKDHPLMDDSVTPVGDRPRLVKRDVKYTQIVVDRVRALNGTIYDVMFISTDQGALHKAISYENGMHIIEETQLFPKFEPVQTLLLSSKKSRRYLYAGSNSGVVQSPVAFCDTYTTCFDCVLARDPYCAW
What is the function of this protein?
Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity).  Regulates GABAergic synapse development (By similarity).  Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).  Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity).
What are the official names of this protein?
Semaphorin-4D, Collapsin-4, COLL-4.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HEM3_DESAP
Sequence: MRREVVVGTRGSRLALAQADWVIDHLRARYPRVSFVRKEIRTTGDNILEVALAKIGDKGLFTKELEQALLHREIDLAVHSMKDLPTGLPEGLVIGAVSVREYPGDVFISRGGERLEELPAGAVLGTSSLRRTAQLLAYRPDLQVIPVRGNVQTRLRKLDEGVVDALVLAWAGLFRLGLTERVTHRIPVAMCLPAVGQGALGIEARADDAEILEMLRTIDHAPTRAAVQAERTLLRRLEGGCQVPVGALGRFRDGRLVLEAVVASLDGTELVRAQESGPADRPEALGNSLAVRLLEMGAGEILARVRAGA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: URC1_LACKL
Sequence: MSPIAVTSQTPATEVPSVKEIPQVITKSSPVENLILTTYPEDSSPIPLQWGAPSTDSRGPIIATRYKEGLAKHNAIGAHSGSYCVYHALAVGTKQLDPEHVADYTNSQPAFAVPEQKTWYNDEDIVAMDPFGHLTPYLFDEVSTKENVEIRPTIAVTKATMQLFEMKDAVEKGRLEVDGEVVINKNGDLNVSKVAVEPVWYLPGVAKRFGVTEEELRKALFEDTNGMYPELVTRPDIKVFLPPIGGLTVYIFGNPDFVSDPSKKLALRVHDECNGSDVFGSDICTCRPYLMFGIEEAVKEAQNGGSGVVVYFRKEGRALGEVTKYLVYNARKRGGDTADEYFHRTECIAGVRDMRFQQLMPDVLKWLGISKIDRMLSMSNMKHDAIVDQGIPIIERIPIPDELVPPDSRVEIDAKINSGYFTNGKVMDKNELKSVQGRTWNDVK
What is the function of this protein?
Involved in uracil catabolism.
What are the official names of this protein?
Putative GTP cyclohydrolase URC1, Uracil catabolism protein 1.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ANFD_RUMHU
Sequence: MPHHEFECSKVIPERKKHAVIKGKGETLADALPQGYLNTIPGSISERGCAYCVAKHVIGTPMKDVIHISHGPVGCTYDTWQTKRYISDNDNFQLKYTYATDVKEKHIVFGAEKLLKQNIIEAFKRFPQIKRMTIYQTPCTALIGDDINAIAEEVMEEMPEVDIFVCNSPGFAGPSQSGGHHKINIAWINQKVGTVEPEITGDHVINYVGEYNIQGDQEVMVDYFKRMGIQVLSTFTGNLSYDGLRAMHRAHLNVLECARSAEYICNELRVRYGIPRLDIDGFGFKPLADSLRKYGMFFGIEDRRKAIIDEEVARWKPELDWYKERLMGKKVSVWPGGSKLWHWAHVIEEEMGLKVVSVYTKFGHQGDMEKGMPRCGEGTLAIDDPNELEGLEALEMLKPDIILTGKRPGEVAKKVRVPYLNAHAYHNGPYKGFEGWVRFARDIYNAIYSPIHQLSGIDITKDNAPEWGNGFRTRQMLSDGNLSDAVRNSETLAQYTGGYDSVSNVREREYPAFERKVG
What is the function of this protein?
This iron-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.  Other nitrogenase complexes utilize a molybdenum-iron protein or a vanadium-iron protein.
What are the official names of this protein?
Nitrogenase iron-iron protein alpha chain, Dinitrogenase 3 subunit alpha, Nitrogenase component I.
Protein: CAO_ORYSJ
Sequence: MTTVASLSLLPHLLIKPSFRCCSRKGVGRYGGIKVYAVLGDDGADYAKNNAWEALFHVDDPGPRVPIAKGKFLDVNQALEVVRFDIQYCDWRARQDLLTIMVLHNKVVEVLNPLAREFKSIGTLRKELAELQEELAKAHNQVHLSETRVSSALDKLAQMETLVNDRLLQDGGSSASTAECTSLAPSTSSASRVVNKKPPRRSLNVSGPVQPYNPSLKNFWYPVAFSSDLKDDTMVPIDCFEEQWVIFRGKDGRPGCVMNTCAHRACPLHLGSVNEGRIQCPYHGWEYSTDGKCEKMPSTKMLNVRIRSLPCFEQEGMVWIWPGNDPPKSTIPSLLPPSGFTIHAEIVMELPVEHGLLLDNLLDLAHAPFTHTSTFAKGWSVPSLVKFLTPSSGLQGYWDPYPIDMEFRPPCMVLSTIGISKPGKLEGKSTKQCSTHLHQLHICLPSSRNKTRLLYRMSLDFAPWIKHVPFMHILWSHFAEKVLNEDLRLVLGQQERMINGANVWNWPVSYDKLGIRYRLWRDAIERGVDRLPFSNQSESGS
What is the function of this protein?
Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b.  Acts specifically on the non-esterified chlorophyllide a and not on chlorophyll a.
What are the official names of this protein?
Chlorophyllide a oxygenase, chloroplastic, Chlorophyll a oxygenase, Chlorophyll b synthase.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: DNAA_HAES1
Sequence: MSSTVSTLWRDCLLQLQDQVSSNDFTTWLRPLQDDVSESNMILYAPNCFIKGWVENHYLTQITKLAQQLLNNDQFMVKIQDGIKPTEKTTTNVEQKTQNENCHNEITSQQNYRSYLNKNHVFDNFVEGKSNQLARAVAQKVAKNPGEQSANPLFLYGGTGLGKTHLLHAVGNGILANNPHAQVVYMHAERFMQSYVKALKSDRMDSFKRFYRTVDALLIDDIQFFAGKDGTQEEFFHIFNSLFERGRQIILTSDRYPKEIEKIEDRLKSRFGWGISVAIEPPELETRVAILLKKAEEKNMVLPEEVAMFIGGKLRTNVRELEGALNRVHAHAEFTGKAITIDFVRETLKDMLALQDKLVTIENIQKIVADYYRIKISDLKSKRRSRNITRPRQLAMALAKELTNRSLPEIGRNFGDRDHTTVLHACKAIAKLREEDNGIQEDWSNLIRTLSV
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEP3_CANGA
Sequence: MRFRRYFSSTFKRLIDCNSCGVKLQNKQPGALGYYTKKDDNLVKKITLEDVKYLIFGQDIQRIKEMTVDTENYDIKLEKPLICKRCSEALHNNKYNATEFKDIPFEEVEKQIPLHSNVVHTAPILEFPFHINSQLLKNRTFNTTMVFTKADRVFKNKKQVQKQIPIFLDAFFETYLNSKATRNIVTSTLNRWNLDTLFSFLHGTNYFVGEPNSGKSTLINALLRRLFGVKIRGNDVKNFELDKQAEEELAVSKKFFLEKQLAGVSHIPNLTRTLQAYKIKQKIIYDLPGYSNYNSYRIDEFIDPKWLQRFRKTSIFSEKRVKKKRYDSIVGNENGKCLTLGGIFYLVPPPTTINQIVCYIPGELRQFHNTDRGIEVLGKSGSKEHPLNKYCGIKPGIGKEKYIRHIIPPFQGPIEVVLKDIGYFSLTPTGKYEYKGLYELWVLDGIDVCIRKPLERVAEDSYDKSQEGKYYIKEPVVSHTYVVAHNDPNPLQTVKESYEKVKERTDEILNKYNLEKFGNNMWHFKW
What is the function of this protein?
May be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PS1C1_PANTR
Sequence: MTCTDQKSHSQRALGTQTPALQGPQLLNTDPSSEETRPPHVYPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFSSVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI
What are the official names of this protein?
Psoriasis susceptibility 1 candidate gene 1 protein homolog, Protein SEEK1.
Protein: FLGI_HELPJ
Sequence: MKRVFLWLIFVLAFHKLLAEKIGDIASVVGVRDNQLIGYGLVIGLNGTGNKSGSKFTMQSISNMLESVNVKISADDIKSKNVAAVMITASLPPFARQGDKIDIHISSIGDAKSIQGGTLVMTPLNAVDGNIYALAQGAIISGNSSNLLSANIINGATIEREVSYDLFHKNAMTLSLKNPNFKNAIQVQNTLNKVFGNKVAIALDPKTIQITRPERLSMVEFLALVQEIPINYSAKNKIIVDEKSGTIVSGVDIIVHPIVVTSQDITLKITKEPLNDSKNMQDLDNNMSLDTAHNTLSSNGKNITIAGVVKALQKIGVSAKGMVSILQALKKSGAISAEMEIL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: IF2_SHESH
Sequence: MADTTVEKLASEVGKSADRLVEQFSEAGIKKSKADTVSESEKQQLLEFLKKQHGGESAPTKMTLQRKSVSTLSVGSGSASKDVKVEVRKKRTFVKRDPAADAEAEAAAKAEAEVKAAEEAASKAKADAEAKAKAEAKAKADAEAKEKAKASAAEKAKPVAVTAEEKAAQDEADKLQAAKDTAAKAKADEEAKAAAEIARKLAEENSARWAEEEKQRKESEKTGDHHVTTSTEARAAEDTADANAEKRGRRPRKATPAPAAAPANTGKGKRRGGKDNRRDSRNARGGRNARNNRSVAPESMDHAFTKPVAAVKTDVSIGETVSVSELASKMSIKATEIIKQMMKMGSMVTINQVLDQETAQLVAEEMGHKVVLTRENELEHQVLADRDANIQAESRAPVVTIMGHVDHGKTSLLDYIRRAKVASGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTAMRARGAQATDIVILVVAADDGVMPQTIEAIQHAKAGGVPLIVAVNKIDKPEADPERVKSELSQHGVMSEDWGGNNMFVHVSAKSGEGIDELLEGILLEAEVLELKAIKEGMAAGVVVESKLDKGRGPVATVLVQEGTLKQGDIVLCGLEYGKVRAMRDENGRAIKEAGPSIPVEILGLSGVPSAGDEATVVRDERKAREVALYRQGKFRDVKLARQQKSKLENMFANMVEGEVQELNIILKADVQGSLEAIADSLNKLSTDEVKVNIIARGVGGLTETDASLAAASNAIMIGFNIRADAQARKVIDAESVDLRYYSVIYHLIDEVRNAMSGLLAPEFKQVILGLAEVRDVFKSPKIGAIAGCMVTEGTIKRSAPIRVLRENVVIYEGELESLRRFKDDVADVRNGMECGIGVKNYNDVRVGDQIEVFETIEIARSLEE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_NEIMF
Sequence: MNVFKQQLEQLGAQNQYRSIPDLIHQGRYITRENRKMLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFSRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEAALAKAEYLQRQGYYCLPIRPPTVPKNTSRIRLSLTADMTTDEVRQFAVCL
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: ZUPT_ECOLI
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake (PubMed:11790762, PubMed:15716430, PubMed:20225068, PubMed:34793140).  Has broad metal specificity and can also mediate the uptake of cadmium, cobalt, iron, manganese and possibly copper (PubMed:11790762, PubMed:15716430, PubMed:20225068, PubMed:34793140).  Has a slight preference for zinc (PubMed:20225068).
What are the official names of this protein?
Zinc transporter ZupT, Divalent metal ion transporter ZupT, Zinc uptake transporter.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CDD_ECO57
Sequence: MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLADAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHNIDRVLLA
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: FKBP9_BOVIN
Sequence: MAIRARSWRPPPPPLLLLLLWVTGQAAPVAGLGLGSDSELQIERRFVPEECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLIAGMDQALVGMCVNERRFVKIPPKLAYGSDGVSGVIPPDSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDGISIENKVVPENCERRSQSGDFLRYHYNGTLLDGTFFDSSYSRNRTFDTYIGQGYVIPGIDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGFGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFVWNGEVSANLFEEIDKDGDGEVLLEEFSEYIHAQVASGKGKLAPGFDAEMIVKNMFTNQDRNGDGKVTAEEFKLKDQETKHDEL
What is the function of this protein?
PPIases accelerate the folding of proteins during protein synthesis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP9, PPIase FKBP9, FK506-binding protein 9, FKBP-9, Rotamase.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: RPPH_PASMU
Sequence: MIDFDGYRPNVGIVICNSKGQVLWAKRYGQNSWQFPQGGINDNESAEQAMYRELFEEVGLSPKDVKILYISKHWLRYKLPKRLLRYDSKPVCIGQKQRWFLLQLVSDEKNINMQSSKSPEFDGWRWVSFWYPVRQVVSFKKEVYRKAMKEFASVLFDGAKENLLSSKSNESDLKTHHTTKKSTFLTKHSKKHFHKSRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: MIAA_ECOUT
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLNIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SYS_METST
Sequence: MLDIKLFREEPNKIFDSEKKRFRDTINVEKVIEYDNLWREGLQNLNNLRSEKNKLSKSFKQAKKDGNLEEVISKSKKVASDIKELEPKIEEYERIRDEYRYKVGNIIDENVPVSDTEDDNEVIRTNGDFPSFDFEPLNHVDLINLIDGADTDTASQIAGSRFYYLKQDILFLNLALIQFALNELKDKGYTPLQTPFFIKSEVAEETSELGEFEETLYKVENEDLYLIATAEQTLAALHRNEIIDSEDLPLRYCALSTCFRKEAGSHGKDTLGIFRVHQFEKVEQFIYATPENSTLEHEKLLEVTEGIYQKLGLPYQIVAIVSSALNDNAAIKYDLEAWFPGSGTYRELVSCTNCKDYQARKINTRYGKAGAGDAQILHTLNSTAIATERTICCILENYQQEDGSIKIPDVLIPYMNGKTIIEAK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_ENTFA
Sequence: MTRLLVVYFLISALLVGLDQWSKYLTVQNISLGETKEFIPGFLSLTHLRNTGAAWSLLEGKMIFFYVITVIVSVVIIYLLIKNYKKSIWYSVGLSFVLAGAIGNFIDRVRLGYVVDMLQTDFMNFPIFNVADSTLVVGVICIFIYLILDEKAAKEGKNGTN
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUB_SYNC1
Sequence: MNGILIVDKPQGMTSHAVVGRIRRLFGLRKVGHAGTLDPLATGVLVVALGQATRILQFLMQENKVYRASLVLGKTTDTQDSEGQIVATSDPGHIDAQSVADVCHSMVGSYDQMPPMYSALKKDGVPLYKLARQGVEVSRKPRRITIFDLQLLAVEPPNITFDVHCSKGTYVRTICHDIGVKLGCGAHLTALRRLRSAPFDVKEAVTLEAIELMAPEDRPELLLSIAEALREYPSLNVCPEGIKRLGYGIPPTADMIADTIDFEEGTQVLLVGPGGALAMATYVPSRARESRGDFELLRVFNDGGSS
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: FAR6_SARBU
Sequence: TPTHDFMRF
What are the official names of this protein?
FMRFamide-6, SabFMRFamide-6.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_RICBR
Sequence: MEVILIKPVRKLGKIGEIHKVADGFGRNYLLPQKLAIRATELNKELIVKQKHELEEKDKQIKSEITKINDLIKDQKLIFVRQTSDDGKLFGSVNNKEIAEKLSQAVSYPISHLNIILDTQIKSTGIYKVEVRLHAELSTEVTVIVARSESEIQDYLREQKTEKSTTEPLAESA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: H2AX_CICAR
Sequence: MSSTATTKGGRGKPKASKSVSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKNNRIVPRHIQLAVRNDEELSKLLGSVTIANGGVLPNIHQTLLPKKVGKGKGEIGSASQEF
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).
What are the official names of this protein?
Histone H2AX.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: T23O_BURA4
Sequence: MKPPGDNAPAGCPFSGARAAQPAHEAPHVPGDAAGETGWHDAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIASERLERDWTQPMRHDETVEAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: FRSA_SALPB
Sequence: MTQANLSETLFKPRFKHTETSTLVRRFNRGSQPPMQSALDGKNVPHWYRMINRLMWIWRGVDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAKQAMDWQQKACQEQDAMRSGRYWLHASTLYNIAAYPHLKGDELAEQAQALANRAYEEAAQRLPGSLREMEFAVPGGSPVTAFLHMPKGDGPFPTVLMCGGLDAMQTDYYTLYERYFAPRGIAMLTLDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLEAPRLKAVACLGPVVHALLSDPQRQSTVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGFWKNDPFSPEEESRLITTSSSDGKLIEIPFNPVYRNFDRALQEITDWINHRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: PUR7_MYCTO
Sequence: MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGALRANQLRDRTLQTYVQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPGA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.