PharMolix/UniProtQA huggingface dataset:
Protein: MED6_ANOGA
Sequence: MNPGRLGLAPLLQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKAIAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSDTANASNNHGGAAGDSDHVGADATLIKQEPTEGGVGRAGNNDVPPEKKMKL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 6, Mediator complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL25_DINSH
Sequence: MAGEIPDLVAEPRAGTGKGAARQARRDGYVPGVVYGGGADPQPIQIKFNELLRRLKAGRFMATLFNLKVEGQEDVRVICRNVQRDVVKDLPTHLDLMRLRRTSKVNLFIPVEFINEGAAPGIKKGGVLTAVRPEVELRVTAGDIPESITVDLTGLDIGDTVTISSVTLPEGATPTIDRDFVIANIQAPSGLRSADNEADEEETEEATAEEV
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: LYRM2_DANRE
Sequence: MAVSRLPPAALSLKQFLQRQKVLCLYRDLQRTIRRVPHESDRKYLRDWARDEFRRNKSNTDQDAIRMMISQAHNHLEELRRSLALAGC
What is the function of this protein?
Involved in effecient integration of the N-module into mitochondrial respiratory chain complex I.
What are the official names of this protein?
LYR motif-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
Protein: RAB7L_MOUSE
Sequence: MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDSEMVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPSGEPVPCLLLANKSDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLVEKMMNNSREDVMSLSTQGNYINLQAKPSSGWTCC
What is the function of this protein?
The small GTPases Rab are key regulators in vesicle trafficking (By similarity).  Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity).  Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity).  Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity).  Regulates also neuronal process morphology in the intact central nervous system (CNS) (By similarity).
What are the official names of this protein?
Ras-related protein Rab-7L1, Rab-7-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasm, cytoskeleton. Note=Colocalizes with GM130 at the Golgi apparatus (By similarity). Colocalizes with LRRK2 at dynamic tubules emerging from and retracting to the Golgi apparatus (By similarity). Colocalizes with TGN46 at the trans-Golgi network (TGN) (By similarity).
Protein: FABZ_SHIFL
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_SHEAM
Sequence: MTLTVKCPQCQKPVTWDASSAFKPFCSERCKLIDLGDWASEKHAIPVKDDISEELLDQLGYEEADFFKTAD
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: CHSE3_MYCTU
Sequence: MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNPMEELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR
What is the function of this protein?
Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism.  It contributes partly to the virulence by increasing the efficiency of beta-oxidation (PubMed:26161441).  Catalyzes the dehydrogenation of the five-carbon steroid side chain of 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24-oyl-CoA (PubMed:26161441).  Can also use 3beta-hydroxy-chol-5-ene-24-oyl-CoA, and shows weak activity with cholyl-CoA and deoxycholyl-CoA (PubMed:25645564).
What are the official names of this protein?
Acyl-CoA dehydrogenase FadE34, ACAD, 3-oxochol-4-en-24-oyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: MTAD_DESRM
Sequence: MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAMPGFINCHTHAAMTLLRGYADDLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGTTCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKALIEAEELARNWNGKADGRITVMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLGLFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGTDGTASNNNLDMLEELRAGSFLQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKEGMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVIDGKVVMLDRVVKTIDEERVMYEVRERAARLAGK
What is the function of this protein?
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively.  Is also able to deaminate adenosine.
What are the official names of this protein?
5-methylthioadenosine/S-adenosylhomocysteine deaminase, MTA/SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: HRCA_MYCMM
Sequence: MGTADERRFEVLRAIVADFVATHEPIGSKSLVERHNLGVSSATIRNDMAVLEAEGYIAQPHTSSGRVPTEKGYREFVDRLDDVKPLSMVERRAIQGFLESGVDLDDVLRRAVRLLAQLTRQVAVVQYPTLSTSKVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHQLSQLRELLGQALEGKKLAAASVAVADLAGQLSGAGGLGDAVGRSATVLLESLVEHTEERLLMGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQIVGTSMVSTAYGSNDTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVLGAR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RL23_BACC3
Sequence: MRDPRDIIKRPVITERSMEMMAEKKYTFDVDVKSNKTEVKDALEAIFGVKVEKVNIMNYKPKAKRVGRHAGFTSRRRKAIVKLTADSKEIEIFQGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: AKTPA_XENLA
Sequence: MNPFWNMSSASVRKRSENDEKISTGDQKISPPRSSSAKKQLPPIPKNAVPITKPISPSLSVQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGECPRLVFDVPVFHPLVDPISGELDVKRAFTKWRRNHNHIWQVLMYARRIFYKIDTTSPLNPEAAVLYEKDVQLFKSKVVDSVKLCNSHLFDQPKIEDPYAIIFSPWNPVLHDDARERMLAQKKKSEEQSKGLHVSGLSWVKPGSVLPFSKEENSLQT
What is the function of this protein?
May function to promote vesicle trafficking and/or fusion.  May also regulate apoptosis (By similarity).
What are the official names of this protein?
AKT-interacting protein homolog A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: FYV10_COCIM
Sequence: MAVELTSIKLNPENHLLLDQPLLRVPHELARRNFKSVQRIVEREKDYVLPALKETANASLSGSKNPTETIEALDAMITRMQGLKRKMEVLHEEEKKIATQSQKRIQYIQDLYKIPSLADVKYEQWSRTRLNRLLADHMLRSGYLESAKQLAEDKGIADLVDLSVFAQCQRIAHSLRRGETKEALQWCGENKVALKKIQNRLEFELRLQQYIEVLRVGDKAEARQHAKKFLTPHSETQSHDIQRAAGLLAYPPDTRAEPYMSMYSLERWKHLSDLFIRTHHDLLSLSSRPLLQIALSAGLSALKTPSCHSAIASSRASPLSLSTSICPICSTELNELARHVPYAHHTKSSVENDPVVLPNRRVYGMDRLSDMSKKAGVPEGKVKDPITGEIFDVSEVKKVYIS
What is the function of this protein?
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
What are the official names of this protein?
Protein FYV10.
What is the protein family that this protein belongs to?
Belongs to the FYV10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATPB_MYXXD
Sequence: MSAQVPTAGRIIQVLGPVVDVEFPPGGLPEVYTALKVTNANLSAAADNLTLEVAQHLGENTVRTIAMDSTEGLGRGMAVTNTGAPIQVPVGKATLGRILNVTGEPVDEMGPVKAQEYWSIHRAPPPFTEQDVRVQMFETGIKVIDLLAPYTRGGKIGLFGGAGVGKTVLLQELIRNVAVERGGFSVFAGVGERTREGNDLYHEMQDTKVIQTDNLEASQAVLVYGQMNEPPGARARVALSALTMAEYFRDVEGRDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGGLQERITSTTKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLNRSIAELAIFPAVDPLDSTSRILDPAVIGAEHYGVARKVQGILQRYKELQDIIAILGMDELSEDDKLVVARARKIQRFLSQPFFVAKVFTGKDGRYVKLQDTIQGFKEIAEGKHDDIPEGAFYMTGSIDEVVENARKLAAS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MSHD_BEUC1
Sequence: MQAYDDEIVGTALASNVLALADRVRTADGVEALSEQHRLALEHPGLRAHHLVVTDPAGAVVGYASVLGSSVEMLVDAAHRGEGVGHRLAEAALAVEPTLAFWAHGDLPGAAQLAEAIGLRRVRELWHLGRDLAPAGAGGDEAALLATPLPGGERLRTFGGTEAEEHAWLALNARAFASHPEQGAMTLEDLRVREGETWFDPSLLWLVHDDGDGALLASMWLKVPDAATGEIYVLGVDPGAQGRGLGRALTDRALDVLRARGVDRVELYVEGENARARALYEHSGFTPVAVHAQYGIP
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: ARGB_BURL3
Sequence: MSEPIDLSQIAPTLKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDHALKKIGKAGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVMLINHFGGHAVGLTGKDGGLIHARKLLMPDRDNPGQYIDIGQVGEVEAINPAVVKALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLLMMTNIPGVMDKDGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_EHRRW
Sequence: MATKKSGGSSSNGRDSRGRRLGVKKFGSEKVIPGNIIIRQRGTKYHPGRNVGIGKDHTIFSKVSGVVYFRKGALNKTFVDVLEVNSAS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: EFTU2_RHOPS
Sequence: MAKAKFERNKPHCNIGTIGHVDHGKTSLTAAITKVLAETGGATFTAYDQIDKAPEEKARGITISTAHVEYETSNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPALVVFLNKCDMVDDPELLELVEMEVRELLSKYDFPGDDIPIVKGSALAALENSDAKLGHDAILELMKAVDAYIPQPERPIDQPFLMPVEDVFSISGRGTVVTGRVERGIVKVGEEIEIVGIRDTQKTTCTGVEMFRKLLDQGQAGDNIGCLLRGTKREDVERGQVLCKPGSVKPHTKFKAEAYILTKEEGGRHTPFFTNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNIAMEVHLIVPIAMEEKLRFAIREGGRTVGAGVVASIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPM_EXISA
Sequence: MTGTTWHLLRTESTSPAENMAIDEAIANWVAKGELKPTLRFYSWAPHAISVGRFQRATRDLDRDALEANNIPVVRRLTGGRAVLHADELTYSVILPESTPALPTNIIESYRLLTEGVRRGYRELGVPAEFSVPLTEEDREALRKPKSAVCFDAASYYELAVDGKKIAGSAQVRHQGAVLQHGSIPLSVDDEVLFDCFAMDETEKQEAKTRFSEKAVALNDTLKRFVSFDEVAAAFETGFKDAFSLTFEPLVFTKEQQAEIDLLVKKYESDEWVWKR
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.
What are the official names of this protein?
Octanoyltransferase LipM, Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the octanoyltransferase LipM family.
Protein: SEC11_PICST
Sequence: MNIRQQLTQFLSLAYVFTSAFVIWKSLGIITNSHSPIVVVLSGSMEPAFQRGDILFLWNRDQEAKVGDIVVYEIQGRNIPIVHRVLREHHNSDKQLLLTKGDNNAVDDLGLYAKKQKYLNQKTDLVGSVKAYLPKLGYVTILITENVYFKYGMLGLMCISTLLTNE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: TRPD_BACCZ
Sequence: MNNYLRKLVEGQHLTEEEMYKAGLLLLNENILESEIAAFLVLLKAKGETAEEIYGLVRALREKALPFSNHIQGAMDNCGTGGDGAQTFNISTTSAFVLAGADVKVAKHGNRAVSSKTGSADLLEELGVNISSTPNEIDYLLEHVGIAFLFAPVMHPALKRIMKIRKELNVPTIFNLIGPLTNPVNLETQFVGIYKRDMLLPVAQVLQKLGRKQALVVNGSGFLDEASLQGENHVVILKDNEIVETSIEPKKYGFSIVKNEEIRGGNSKENAKITLGVLSGEKSVYRDTVLFNAGLALFANGKAKTIEEGITLAAHSIDSGKALAKLNLLIAASNEKLERVN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PSBT_YUCGL
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AKIR2_PIG
Sequence: MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPSSAAAATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPGTPSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
What is the function of this protein?
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity).  Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity).  Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity).  Also involved in adaptive immunity by promoting B-cell activation (By similarity).  Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity).  Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:25686036, PubMed:28327665).
What are the official names of this protein?
Akirin-2.
What is the protein family that this protein belongs to?
Belongs to the akirin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions.
Protein: AGP25_ARATH
Sequence: MAFSFLNKLLIIFIFIFISLSSSSPTISLVQQLSPEIAPLLPSPGDALPSDDGSGTIPSSPSPPDPDTNDGSYPDPLAFSPFASPPVSSPSPPPSLPSAGVLLISLIISSASFLAL
What is the function of this protein?
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
What are the official names of this protein?
Classical arabinogalactan protein 25.
What is the protein family that this protein belongs to?
Belongs to the classical AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: THNB_PHOLI
Sequence: KSCCPSTTARNIYNTCRLTGASRSVCASLSGCKIISGSTCDSGWNH
What is the function of this protein?
Thionins are small plant proteins which are toxic to animal cells.  They seem to exert their toxic effect at the level of the cell membrane.  Their precise function is not known.
What are the official names of this protein?
Ligatoxin-B.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44) family.
What are the subcellular locations of this protein?
Secreted.
Protein: LRC59_HUMAN
Sequence: MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ
What is the function of this protein?
Required for nuclear import of FGF1, but not that of FGF2.  Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
What are the official names of this protein?
Leucine-rich repeat-containing protein 59, Ribosome-binding protein p34, p34.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.
Protein: RPOA_PANGI
Sequence: MVQEKVRVSTRTLQWKCVEARADSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSEKIPHEYSTLVGIQESVHEILMNLKEIILKSNLYGTCDASICIRGPGYVTAQDIISPPYVEIVDNTQHIASLAEPIDLCIGLQIERNRGYLIKTPNNNFQDGSYPIDAVFMPVRNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALHQASRNLIDLFIPFLHTEEENLHLADNQHTVPLPPFTFHEKLTKLRKNKKKIALKSIFIDQSELPPRIYNCLIRSNIYTLLDLLNNSQEDLMKIEHFRIEDVKAILGILEKHFAIDLPKKLKIGFESLAQSIYSESG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LACD_STAAE
Sequence: MSKSNQKIASIEQLSNNEGIISALAFDQRGALKRMMAKHQTEEPTVAQIEQLKVLVAEELTQYASSILLDPEYGLPASDARNKDCGLLLAYEKTGYDVNAKGRLPDCLVEWSAKRLKEQGANAVKFLLYYDVDDAEEINIQKKAYIERIGSECVAEDIPFFLEVLTYDDNIPDNGSVEFAKVKPRKVNEAMKLFSEPRFNVDVLKVEVPVNMKYVEGFAEGEVVYTKEEAAQHFKDQDAATHLPYIYLSAGVSAELFQETLKFAHEAGAKFNGVLCGRATWSGAVQVYIEQGEDAAREWLRTTGFKNIDDLNKVLKDTATSWKQRK
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: PT5_PINTA
Sequence: MSSLAVDDAERRVGDYHPNLWDDALIQSLSTPYGASPYRDVAEKLIGEIKEMFASISIEDGDDEICYFLQRLWMIDNVERLGISRHFENEIKAAMEDVYSRHWSDKGIACGRHSVVADLNSTALAFRTLRLHGYSVCSDVFKIFQDQKGEFACSADQTEGEIKGILNLLRASLIAFPGERILQEAEIFATTYLKEALPKIQGSRLSQEIEYVLEYGWLTDLPRLETRNYIEVLAEEITPYFKKPCMAVEKLLKLAKIEFNLFHSLQQTELKHLSRWWKDSGFAQLTFTRHRHVEFYTLASCIAMEPKHSAFRLGFAKLCYLGIVLDDIYDTYGKMEELELFTAAIKRWDTSTTECLPEYMKGVYMAFYDCVNEMARQAEKTQGWDTLDYARKTWEALIDAFMEEAKWISSGYVPTFQKYLDNGKVSFGYRAATLQPILTLDIPLPLHILQEIDFPSSFNDLASSILRLRGDICGYQAERSRGEQASSISCYMKDNPGSTEEDALSHVNAMIGDKIPEFNWEFMKPSKAPISSKKYAFDILRAFYHLYKYRDGFSIAKIETKKLVMRTVLDPVPM
What is the function of this protein?
Involved in sesquiterpene (C15) biosynthesis.  The major product is alpha-farnesene.
What are the official names of this protein?
Alpha-farnesene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.