PharMolix/UniProtQA huggingface dataset:
Protein: SECA_XANC8
Sequence: MINSLLTRVFGSRNERQLRQLNRLVTQINALEPTIEKLSDAELQAKTPEFKQRLAAGESLDKILPEAFAVCREASRRVLGMRHYDVQLIGGMVLHLGKIAEMRTGEGKTLVATLPVYLNALEGQGVHVVTVNDYLARRDAAQMGKLYNWLGLSVGVVYPGMPHSDKHAAYAADITYGTNNEFGFDYLRDNMALSRADRYQRKLHYAIVDEVDSILIDEARTPLIISGPADESPELYIRVNRIVPQLTKQESEEGEGDYWIDEKGKQVHLSEAGMGHAEELLLQAGILENADDGLYAAQNLSVVHHLNAALRAHAIYQRDVDYIVRDGEVVIVDEFTGRTLSGRRWSDGLHQAVEAKEGVPVQRENQTLASITFQNLFRMYKKLSGMTGTADTEAYEFQSIYGLEVVVIPTNRPTVRKDHPDQVFLNRKGKFNAVLADIEDCAKRGQPVLVGTTSIETSEMLSEHLRKAGVKHEVLNAKQHEREATIVANAGQPGAVTIATNMAGRGTDIVLGGSLEAEYHVLGEDATEEARFKIKTDWQRRHDAVKAAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDNLMRIFASDWVQKAMRMMGMKEDDVIEDRLVSRQIEKAQRKVEAHNFDIRKNLLDFDDVNNDQRKVIYAQRDDLLDAESVKDNVDGIRGDVIYDLVARFVPPNSVDEQWDLQGLEATLESELGMPLALRELAKTQEELDAEQIAAKVQTAVDAHFAEKEAAVGADTMRALEKHVMLTVLDQGWKEHLAKMDYLRQGIYLRGYAQKQPKQEYKKEAFELFSEMLENVKREVINLLARVRIRSEEEVAELEEQERRQAEARLLASQFQHQDAGGYGADEEVEQMQGGNAPVPVSQVTRDEPKVGRNDPCPCGSGKKYKHCHGQLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: SYH_GRATL
Sequence: MKSYFMQPLRGTKDILPNEINYWHHIHDKALTILSLHNYSEIRTPIIESTSLFKRSIGETSDIINKEMYTFTDQGDRSITLRPEATASIARAFISNKLYHSNIQRLWYLGPMFRYERPQSGRQRQFHQLGIECIGSINPMADTEVIHLANQLLKELQVKNYILEINSIGTLEERQSYKLDLVEYLSQYQQDLDQDSKNRMYSNPLRILDSKNLKTQEILDGAPKLKKYLNKRSTEHFYLVCTYLNNLNITYKINYKLVRGLDYYNQTAFEIKTNSKNSQNTICGGGRYDTLIEQLGGPKTPAVGWAIGIERLLKIIEDKLILPKQKINVYIATQGLAAQKKIWEIIQALEKKNIKFELDLSNTSFHKQIKKAGKLGAKFCIILGDQEIMDNCVTIKRLDEYVQYTAQYSNFLQEIHKLQH
What are the official names of this protein?
Histidine--tRNA ligase, chloroplastic, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROC_BACTN
Sequence: MFNSFGNIFRLTSFGESHGKGVGGVIDGFPSGITIDEEFVQQELNRRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPSHADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKLEGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQPVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGGIQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEAMAAMTILDYYLLDKTTQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y2407_BRADU
Sequence: MGSTTDKIKGNANEAIGKAKQGIGEATGSDRLKGEGVVQEVKGKGQQAMGDAKDAAKEAIDRAAAAARRAAE
What are the official names of this protein?
UPF0337 protein bsl2407.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: ATP6_STAAE
Sequence: MDHKSPLVSWNLFGFDIVFNLSSILMILVTAFLVFLLAIICTRNLKKRPTGKQNFVEWIFDFVRGIIEGNMAWKKGGQFHFLAVTLILYIFIANMLGLPFSIVTKDHTLWWKSPTADATVTLTLSTTIILLTHFYGIKMRGTKQYLKGYVQPFWPLAIINVFEEFTSTLTLGLRLYGNIFAGEILLTLLAGLFFNEPAWGWIISIPGLIVWQAFSIFVGTIQAYIFIMLSMVYMSHKVADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEOB_METC4
Sequence: MARALLIVLDSVGIGGAPDADRYGDAGSDTVGHIAEACAAGRGDRPGLRAGPLRMPNLTALGLGLACEGATGRVPPGLAPDGPVRALWGHAVETAAGKDTPSGHWEIAGVPVREAWGHFPDTQPAFPAELTAALIERAGLPGILGDCHASGTAIIEALGAEHVRTGKPICYTSADSVFQIAAHEEAFGLERLYETCRIAREVCDPYRVGRVIARPFLGSAAEGFRRTSHRKDFSVAPPAGTLLDGLEAAGRAVVSVGKIGDIFAHRATGREIKPAGNAACLDAALDAFAGLPEGGFVFLNLVDFDTEHGHRRDVPGYAAELEAFDARLPEIQAVLKPGDLCVITADHGNDPTWTGTEHTREQVPVLAFGPGLTPRALGRRESFADMGASVAAHLGLPPLGAGQAW
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYYM_RAT
Sequence: MAAPMLRHLCRVPQSGVWTRGPRAVRPGARGMLVAPRARGLFKEFFPESGTKTELPELFDRRRAGSPQTVYCGFDPTGDSLHVGHLLTLLGLFHFQRAGHNVIALVGGSTALLGDPSGRTKEREALSAECVRANARALQRGLETLAANHARLFADGRPWGTFTVLDNAAWFQKQHLMDFLATVGGHFRMGTLLSRLSVQSRLKSPEGMSLAEFFYQVLQAYDFYYLFRHYGCRVQLGGSDQLGNIMSGYEFIHKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNREKTSPFELYQFFIRQQDDSVERYLKLFTFLPLPEIDHIMQLHVKEPEKRIAQKRLAAEVTKLVHGQEGLDSAKRCTQALYHSSIEALEVMSDQELKELFKEASFSELVLDPGTSVIDTCRKANAIPDGPRGYRMITEGGVSINHRQVTNPESVLVIGQHILKNGLSLLKIGKRNFYIIKWLQL
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, mitochondrial, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: AROB_BACC0
Sequence: MGNIHIQTKSKEYDVYVGKESLSHLTTIVQNMQPSVSNIMIISDEAVASLHLQTVVDALQIDQKVFSFVVPSGEKEKSFENFYAAHTSALENKLDRNSLIVALGGGMIGDLAGFVAASFMRGIRFVQVPTTLLAHDSAVGGKVAINHPLGKNMIGAFHQPEAVVYHTPFLQSLPEKEWRSGYAEVIKHALIGDVKLYHWLKEEVQTLADLRDEKLIHILTKAIPVKANIVAQDETEKGVRAHLNFGHTLGHALEKELGYGNITHGDGVAVGMLFAIFLSEQVYKVNLAYEEMKQWFLKYGYPKMPSDLSVERLVGLMKQDKKANAGTIHMVLMQEYGVVNVVSISDETVHIALEAFQKDMV
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAER_RANXA
Sequence: QQDYTGWMDF
What is the function of this protein?
Hypotensive neuropeptide.
What are the official names of this protein?
Caerulein.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACDH2_METPP
Sequence: MATKKIRCALIGSGNIGTDLIYKLKRSAVLEPVWMVGIDAASEGLQRARDLGLKTTAEGVDGLLPHVKADGIQIAFDATSAYVHPENSRKLNALGVLMVDLTPAAVGPLCVPPVNLREHAAKLEMNVNMISCAGQATIPIVYAVSRVQPVDYAEIVASLASKSIGPGTRANLDEFTYTTSDALVRVGGARRGKALAVINPAEPPMIMRNTINCLTDDEPQQARIIDSVLSMIEEVQQYVPGYKLVNGPVFDGRRVSVFMQVAGLGDYLPTYAGNLDIMTAAACRTAEMFAEEILAGTLQLTPVKEAA
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: PUR5_EXISA
Sequence: MSVRYEQAGVNLEAGYEAVSRMKRHVARTMRPEVMTGLGSFGAMIDLGSMNMKHPILVSGTDGVGTKLKLAFALDQHDTIGIDCVAMCVNDCLVHGAEPLYFLDYIATGKAEPAKLERIVAGVAEGCVQAGCALVGGETAEMPGMYPDGEYDIAGFAVGVVEKEDLLDGSTIQDGDVVLGLASSGVHSNGFSLVRHIVEAQGLHYTDEIAMLDTTLGNALLLPTRIYAEAAKAAISTGKVQGMAHITGGGFYENVPRMLPGGLGITFDASSWPSLPVFDWLEQVGNISKQEMFNVFNMGIGYMITVRAEDVELVEAALERVGETAHRIGKVESRPGIRISGVDQ
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_ECODH
Sequence: MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDEKIWSPETDLLLASRYTRDTLEDKAENKRQLQIAMGLKVDDKVPLFAVVSRLTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGVASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMAMDFSWQVAAKSYRELYYRLK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: HMUV_NITWN
Sequence: MRPIIETHSVTMRINGATLVDGIDLSVGSGEMVAIVGPNGAGKSTLLRLLSGDLQPTQGRIELKQADLRSYSAAQLATHRATLSQHVNVTFPFTVEEIVRMGAGDMAIAAAHPLVESAMDEVAIRPLRSRQLPTLSGGEQQRTHFARVLVQLACGEARHGPGLLLLDEPTSSLDLRHQIELVEIAGRRARNGTAVIAILHDLNLAVRFASRIIVIHRGAIVADGPPAQTITDGLIRKVFEVCADIQYHGDGSPVLLPQAMKSIGPGNLL
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL18_THETH
Sequence: MARLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSASSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALAEGAREGGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18, TL24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TAMB_ECOLI
Sequence: MSLWKKISLGVVIVILLLLGSVAFLVGTTSGLHLVFKAADRWVPGLDIGKVTGGWRDLTLSDVRYEQPGVAVKAGNLHLAVGLECLWNSSVCINDLALKDIQVNIDSKKMPPSEQVEEEEDSGPLDLSTPYPITLTRVALDNVNIKIDDTTVSVMDFTSGLNWQEKTLTLKPTSLKGLLIALPKVAEVAQEEVVEPKIENPQPDEKPLGETLKDLFSRPVLPEMTDVHLPLNLNIEEFKGEQLRVTGDTDITVSTMLLKVSSIDGNTKLDALDIDSSQGIVNASGTAQLSDNWPVDITLNSTLNVEPLKGEKVKLKMGGALREQLEIGVNLSGPVDMDLRAQTRLAEAGLPLNVEVNSKQLYWPFTGEKQYQADDLKLKLTGKMTDYTLSMRTAVKGQEIPPATITLDAKGNEQQVNLDKLTVAALEGKTELKALLDWQQAISWRGELTLNGINTAKEFPDWPSKLNGLIKTRGSLYGGTWQMDVPELKLTGNVKQNKVNVDGTLKGNSYMQWMIPGLHLELGPNSAEVKGELGVKDLNLDATINAPGLDNALPGLGGTAKGLVKVRGTVEAPQLLADITARGLRWQELSVAQVRVEGDIKSTDQIAGKLDVRVEQISQPDVNINLVTLNAKGSEKQHELQLRIQGEPVSGQLNLAGSFDRKEERWKGTLSNTRFQTPVGPWSLTRDIALDYRNKEQKISIGPHCWLNPNAELCVPQTIDAGAEGRAVVNLNRFDLAMLKPFMPETTQASGIFTGKADVAWDTTKEGLPQGSITLSGRNVQVTQTVNDAALPVAFQTLNLTAELRNNRAELGWTIRLTNNGQFDGQVQVTDPQGRRNLGGNVNIRNFNLAMINPIFTRGEKAAGMVSANLRLGGDVQSPQLFGQLQVTGVDIDGNFMPFDMQPSQLAVNFNGMRSTLAGTVRTQQGEIYLNGDADWSQIENWRARVTAKGSKVRITVPPMVRMDVSPDVVFEATPNLFTLDGRVDVPWARIVVHDLPESAVGVSSDVVMLNDNLQPEEPKTASIPINSNLIVHVGNNVRIDAFGLKARLTGDLNVVQDKQGLGLNGQINIPEGRFHAYGQDLIVRKGELLFSGPPDQPYLNIEAIRNPDATEDDVIAGVRVTGLADEPKAEIFSDPAMSQQAALSYLLRGQGLESDQSDSAAMTSMLIGLGVAQSGQIVGKIGETFGVSNLALDTQGVGDSSQVVVSGYVLPGLQVKYGVGIFDSIATLTLRYRLMPKLYLEAVSGVDQALDLLYQFEF
What is the function of this protein?
Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane (PubMed:22466966).  In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane.  Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM (PubMed:25341963).
What are the official names of this protein?
Translocation and assembly module subunit TamB, Autotransporter assembly factor TamB.
What is the protein family that this protein belongs to?
Belongs to the TamB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL34_BIFLD
Sequence: MKRTFQPNNRRRHMKHGFRLRMRTRSGRAVINRRRAKGRKTLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RBL_MATST
Sequence: VGFKAGVKDYRLTYYTPEYKTKDTDILAAFRMTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQYIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFIGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKSQAETGEIKGHYLNATAGTCEEMLKRAVFARELGAPIVMHDYLTGGFTANTSLAFYCRDNGLLLHIHRAMHAVIDRQRNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNTIIREASK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SSB_DEIRA
Sequence: MARGMNHVYLIGALARDPELRYTGNGMAVFEATVAGEDRVIGNDGRERNLPWYHRVSILGKPAEWQAERNLKGGDAVVVEGTLEYRQWEAPEGGKRSAVNVKALRMEQLGTQPELIQDAGGGVRMSGAMNEVLVLGNVTRDPEIRYTPAGDAVLSLSIAVNENYQDRQGQRQEKVHYIDATLWRDLAENMKELRKGDPVMIMGRLVNEGWTDKDGNKRNSTRVEATRVEALARGAGNANSGYAAATPAAPRTQTASSAARPTSGGYQSQPSRAANTGSRSGGLDIDQGLDDFPPEEDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (By similarity).  Essential for ionizing radiation resistance.  Stimulates the 5'-3' DNA helicase activity of RecD-like helicase.  Stimulates RecA protein-promoted DNA three-strand exchange reactions in vitro with both D. radiodurans and E. coli-derived RecA.  Complements an ssb deletion in E. coli, but does not complement a ddrb disruption in D. radiodurans.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
What are the subcellular locations of this protein?
Cytoplasm. Note=During log phase, present in multiple foci. 1 hour after irradiation most foci are condensed in the center of the cell's nucleoid, they dissipate by 2 hours later.
Protein: PROA_PSEPG
Sequence: MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALQAAADALDAARAELTAANELDLAAGRANGLEPALLDRLALTPARIDGMITGLRQVASLPDPVGAIRDMSYRPSGIQVGKMRTPLGVIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIATCIQRGLAEAGLPAAVVQVVETTDREAVGALISMPQFVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSQHADLDKAWNVAFNAKTYRYGICGAMETLLVDQRVAERFLPEMARRFQEKGVELRGCERTRALVEAKPATEDDWHTEYLDAILSIRVVNGLDQAIEHINHYGSHHTDSIISEHQGEARQFMAEVDSASVMLNTPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYVVIGDGQLRGQGTC
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_METEP
Sequence: MPELPEVETVRRGLAPAMVGARVARVTLRRPNLRFPFPERFAERLEGTTVLELARRAKYLTAHLDSGESLILHLGMSGRFDVRLPDGSNLSPGDFYLEGALGTPKHDHVVMAFANGATVTYNDARRFGFMDLVATRDLETCRHFASMGVEPLSDALDAPRLARLFARKITPLKAALLDQRLIAGLGNIYVCEALHRSGLHPALPAGALAKPDGSPAPKAKTLVKEIKAVLTEAVAAGGSTLRDYARPDGERGAFQHGFRVYDRVGHACPTKGCTGRIGRIVQGGRSTFFCETCQVLPVR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DXR_HELMI
Sequence: MIKRIAILGSTGSIGRQTLEVVDRSEGRLTVQALAAGSNWKELLAQIEIYRPRLAAMMETEAAERLAEALWERGLPIPVVTGEAGLAEAACLPEVDTVVTAVSGAIGLGPTMAAIEAGKEIALANKETLVAAGPLVMAAARRREVTILPVDSEHSAIFQCLQGQDRRLARLILTASGGPFRDKSLEALHQVTPEDALRHPNWRMGPKITIDSASLMNKGLEVIEARWLFDIDFDDIEVLIHPQSIVHSMVEFADGSILSQMGLPDMRLPIQYALTYPERWQTGWPRLDITKTAALTFRRPDLERFPSLELAITAGRTGGSLPAVMNAANEVAVHAFLDHRIGFMDIPRIVREAMEAHEWQKEPDLPAIRQADAWARRFATERVGEGREVSA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: HELB2_ASPFU
Sequence: MALPIILCLAVILWTSWRLLDALFLSPLHRVPGPVLARLTPLRAIYARLPSRVIPAALADFHSYGDIYLSKPRTITISHPRDVRAILASSEFQKIDVYHGLNDPVMANIVTFSDPKLASRRRRQIGPYFNPSYLAKMEELILRCGCRAVADKWGRLIAQQGHGPQKSVKVNYRHDLQLATFDIMSALAFGRWLDSLKEEGESVAIVEWIMATAVYIGVRINFRLLMVFPFSRLVRRWTRAYAEFVQFSKHAVASRKELLAQGCQKPVDLLQAFIDAEDPDSKVKMTTVEVQAESVGMQLAGSETTAASLTWAVHLFTLYPEYYRIAVDEVRGQFGPNHLITYADCSRLVFLEAFVYEMLRYTPITSSFMPRVSFTKGTTLQGHYIPPGTEIAFNLIAMNNREDVWEEPERFLPDRFLKDPDLKRSVFAFSYGTRSCIGRHLAWMEMMTILANLLKDYDWSLPEDSLYGPHHVDEKGIPIRMPSKCHIVFAPTHPDRDCQLVISRPKT
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
Cytochrome P450 monooxygenase helB2, Helvolic acid biosynthesis cluster protein B2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: TORA_VIBPA
Sequence: MAITRRSFLKGVATTSAASVIGPSLLASASANAAESTGTWKVTGSHWGAFRAHIYAGKVQEIKPLELDKNPTEMLNGIKGIIYSPSRVRYPMVRLDWLKKHKYSADTRGNNRFIRVTWDEALDLFYRELERVQKEYGPWALHAGQTGWNQTGSFNNCTAHMQRAVGMHGNFITKVGDYSTGAGQTIMPYVLGSTEVYAQGTSWSEILENSDNIILWANDPVKNLQVGWNCETHESFKYLAELKEKVAKGEINVLSVDPVKNKTQRYLENDHLYINPMTDVAFMLAVAHVLYNENLYDKKFIDTYCLGFEEFIQYVQGKTKDKVEKTPEWAAAICGVKADKIREFARMLVSGRTQILMGWCIQRQEHGEQPYWAAAVVAAMVGQIGLPGGGISYGHHYSSIGVPSTGFAGPGGFPRNLDQGMKPKWDNNDFNGYSRTIPVARWIDCLLEPGKEINYNGGKVKLPDFKMMVISGCNPWHHHQDRNRMKKAFRKLQTVVTIEFAWTATCRFSDIVLPACTQWERNDIDVYGSYSNKGLIAMHRLVDPLFQSKPDFQIMSELTQRFGRREEYTRGMSEMEWIESLYNDCKKANEGKFEMPEFNEFWEKSVLDFGEGKPWVRHADFRKDPELNPLGTPSGFIEITSRKIGRYGYEHCQEHPMWFEKSERSHGGPGSDKYPFWLQSCHPDKRLHSQMCESEEFRATYAVQGREPVYINPIDAKAKGIKDGDLVRVFNGRGQLLAGAVLTDSYPRGVIRIEEGAWYGPLNEKEGAICTYGDPNTLTQDIGSSELAQATSANTCIVDFEKFTGKVPPVTSFGGPIEVA
What is the function of this protein?
Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.
What are the official names of this protein?
Trimethylamine-N-oxide reductase, TMAO reductase, Trimethylamine oxidase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MNMA_PORGI
Sequence: MDVAALVSGGVDSSVVVHRLCEEGYKPAIFYIRIGMEDKDGYIDCPAEEDIELTTLIARRYGCPFEVVDLHKEYWERVVSYTVETVRRGLTPNPDMMCNKLIKFGCFEERWGYQFDRIATGHYATTDLLNGKTYLSTAKDPVKDQTDFLAQINFAQISKLMFPIGHLLKSEVRAIANAAGLPSAKRKDSQGICFLGKIDYNDFIERYLGKKEGRIIELETGKVIGRHQGYWFHTIGQRKGLGLSGGPWFVVKKDIKRNIILVSRGYDPDAQYGKTIEMETFDFITEDAYEAGYWNREDATPVTFKIRHTPEFTRGLLYKGEKGYRLESEERIQGIAPGQYCVIYDEDHHLCYGSGMITKGR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_RHOP2
Sequence: MTDAPIISPLDQARILSEALPHMQRYDEETIVIKYGGHAMGAEDDAKAFARDIVLLEQTAVNPVVVHGGGPQIATMLKRLGIKSEFAAGLRITDGATIEIVEMVLAGSINKQLVGYINEAGGKAVGLCGKDGNMVTASKATRTMVDPDSRIEEVVDLGFVGEPEKVDLTLLNQLIGHELIPVLAPLATSSSGQTFNVNADTFAGAVAGALKAKRLLLLTDVPGVLDQTKKLIPELSIKDARKLIADGTISGGMIPKVETCIYALEQGVEGVVILDGKVPHAVLLELFTNQGTGTLIHK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.