PharMolix/UniProtQA huggingface dataset:
Protein: IDI2_ENTFA
Sequence: MNRKDEHLSLAKAFHKEKSNDFDRVRFVHQSFAESAVNEVDISTSFLSFQLPQPFYVNAMTGGSQRAKEINQQLGIIAKETGLLVATGSVSAALKDASLADTYQIMRKENPDGLIFANIGAGLGVEEAKRALDLFQANALQIHVNVPQELVMPEGDRDFTNWLTKIEAIVQAVEVPVIVKEVGFGMSQETLEKLTSIGVQAADVSGQGGTSFTQIENARRKKRELSFLDDWGQSTVISLLESQNWQKKLTILGSGGVRNSLDIVKGLALGAKSMGVAGTILASLMSKNGLENTLALVQQWQEEVKMLYTLLGKKTTEELTSTALVLDPVLVNWCHNRGIDSTVFAKR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCA_SALCH
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTAEDTVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFSNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: PP132_ARATH
Sequence: MIRGRTAKVIPRNVIFTLSRSSISESPLISPSRINPKLAGSFSFNIRLLSYFTVRNGFCPDCSVPRDPNFVGLTTQCRSIVRRFCSEKIGSSESSGWTEEVEYLDESGSVLHSGKGIRSVEPGLDDHVMVGGLKKPYMNASSVAKIVEVVQRWKWGPELETQLDKLQFVPNMVHITQSLKIVKEVDAALSLFRWAKKQPWYLPSDECYVVLFDGLNQGRDFVGIQSLFEEMVQDSSSHGDLSFNAYNQVIQYLAKAEKLEVAFCCFKKAQESGCKIDTQTYNNLMMLFLNKGLPYKAFEIYESMEKTDSLLDGSTYELIIPSLAKSGRLDAAFKLFQQMKERKLRPSFSVFSSLVDSMGKAGRLDTSMKVYMEMQGFGHRPSATMFVSLIDSYAKAGKLDTALRLWDEMKKSGFRPNFGLYTMIIESHAKSGKLEVAMTVFKDMEKAGFLPTPSTYSCLLEMHAGSGQVDSAMKIYNSMTNAGLRPGLSSYISLLTLLANKRLVDVAGKILLEMKAMGYSVDVCASDVLMIYIKDASVDLALKWLRFMGSSGIKTNNFIIRQLFESCMKNGLYDSARPLLETLVHSAGKVDLVLYTSILAHLVRCQDEDKERQLMSILSATKHKAHAFMCGLFTGPEQRKQPVLTFVREFYQGIDYELEEGAARYFVNVLLNYLVLMGQINRARCVWKVAYENKLFPKAIVFDQHIAWSLDVRNLSVGAALIAVVHTLHRFRKRMLYYGVVPRRIKLVTGPTLKIVIAQMLSSVESPFEVSKVVLRAPGELVMEWFKKPIVQQFLLNEIPSRSDILMHKMNVMFPSSAPELRSMSPPKPLMSSKAF
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g79490, mitochondrial, Protein EMBRYO DEFECTIVE 2217.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL20_AROAE
Sequence: MSRVKRGVTARARHKKVLDQAKGYRGRRKNVYRIAKQAVMKAGQYAYRDRRQRKRQFRALWIARINAAAREVGLTYSTFMNGLKKAAIEVDRKVLADLAVFDKPAFAALADQARAKLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CAPSD_PAVC
Sequence: MSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVEITANSSRLVHLNMPESENYRRVVVNNMDKTAVNGNMALDDIHVQIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVSFEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRYYFQWDRTLVPSHTGTSGTPTNIYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQTNRALGLPPFLNSLPQSEGATNFGDIGVQQDKRRGVTQMGNTNYITEATIMRPAEVGYSAPYYSFEASTQGPFKTPIAAGRGGAQTYENQAADGDPRYAFGRQHGQKTTTTGETPDRITYIAHHDTGRYPEGDWIQNINFNLPVTNDNVLLPTDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRPHVNAPFVCQHNCPGQLFVKVAPNLTNEYDPDASANMSRIVTYSHFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFNYVPSNIGGMKIVYEKSQLAPRKLY
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1.  The capsid encapsulates the genomic ssDNA.  Capsid proteins are responsible for the attachment to host cell receptor TFRC.  This attachment induces virion internalization predominantly through clathrin-endocytosis.  Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s).  VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell.  Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein.  Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).
What are the official names of this protein?
Capsid protein VP2, Coat protein VP2.
What is the protein family that this protein belongs to?
Belongs to the parvoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YG2U_YEAST
Sequence: MVLSNYLVSFACTQSFFFFASNFIESPPALLKKAFLPNLNRTRSRFPPINYVLLAPLSSYCKWTFQRGYACPVSFLKQAHTDALQLVFFTRCIIWAVFHYRFRVGALTKRARPFVYNRPKRKNINNQEADTKYRSTIKLTSTVTLNLLY
What are the official names of this protein?
Putative uncharacterized protein YGR107W.
Protein: HLNO_SHIS7
Sequence: MTEKIYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGRTHVVNFLGRPVEIGGAGVHWCQPHVFAEMQRYGFGFKEAPLADLDKAYMVFADGQKIDVPPATFDEEYTTAFEKFCSRSRELFPRPYSPLDNHEVSNLDGVSARDHLESLGLNELQLASMNAELTLYGGAPTTELSYPSFVKFHALASWDTITFTDSEKRYHVQGGTNALCQAIFDDCRADSEFGVPVEAVAQTDNGVTVTLADKRVFRALTCVLTLPTKVYADVRFEPPLPPEKRAFIEHAEMADGAELYVHVRQNLGNTFTFCDDPNPFNAVQTYAYDDELGTILKITIGRQSLINLENFDAIAAEIRKIHGDVEVLEALPYNWAMDEYARTSYPAMRKGWFSRYKDMAKPENRLFFAGSATADGWHEYIDGAIESGIRVGREIRHFMKATA
What is the function of this protein?
Involved in the degradation of L-nicotine (PubMed:25002425).  Catalyzes the oxidation of (S)-6-hydroxynicotine (6-hydroxy-L-nicotine) to 6-hydroxypseudooxynicotine (PubMed:25002425).  Oxidation of the pyrrolidine ring of (S)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmyosmine, which hydrolyzes spontaneously to 6-hydroxypseudooxynicotine (PubMed:25002425).  Acts with absolute stereospecificity on the L-form of 6-hydroxynicotine (PubMed:25002425).  Also involved in the degradation of nornicotine, and catalyzes the oxidation of 6-hydroxynornicotine to 6-hydroxymyosmine, which hydrolyzes to 6-hydroxypseudooxynornicotine (PubMed:27568381).  In vitro, converts (S)-nicotine into N-methylmyosmine, which spontaneously hydrolyzes spontaneously into pseudooxynicotine, but catalytic efficiency is about 1900-fold higher with (S)-6-hydroxynicotine (PubMed:25002425).
What are the official names of this protein?
(S)-6-hydroxynicotine oxidase, (S)-6HN oxidase, 6-hydroxy-L-nicotine oxidase, 6-HLNO, L-hydroxynicotine oxidase, LHNO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
Protein: KAD_PROMA
Sequence: MKNRLLFLGPPGAGKGTQASLICKDQGFLHLSTGDLLREEVSGGTDLGKKAELIMNKGELVSDEIVISIVEKRLIKYSEGWLLDGFPRNLAQASLLQNLLGRISQPIEIVLLIEIDDEILTERMLGRGRKDDNKAVIKNRLKIYKDQTSPLVDHYKKQGILKSINGCGSVEDVNSRIKEALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2202_PSYWF
Sequence: MFRWAIIFAVIALLASLLGFGGVAGLSQNFAYIFLVVAVILFIIGFISRRT
What are the official names of this protein?
UPF0391 membrane protein PsycPRwf_2202.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 5HT2C_RAT
Sequence: MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores.  Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.  Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress.  Plays a role in insulin sensitivity and glucose homeostasis.
What are the official names of this protein?
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEXA_BRUA4
Sequence: MLTRKQHELLLFIHERLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLNAQKKFAPSVIEGSLGKTPPPPARPAPVATNDDTSGTVSVPVMGRIAAGVPISAIQNQTHSLSLPPEMIGAGEHYALEVRGDSMIDAGIFDGDTVIIKRGDSANPGEIVVALVDDEEATLKRFRRKGASIALEAANPAYETRIFGPDRVRVQGKLVGLIRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PPIA_PIG
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFDDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQI
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: AROB_BRUAB
Sequence: MNAPTTFADSVTVPVSLGDRSYDILIGKGLVERAGEEVAKRLKGVRVAIVTDENVAAVHLERLQASFARAGIDSTPVIVAPGEKSKSFATLETVTNAILVAKLERGDAVVALGGGVVGDLSGFVAGIVRRGMNFVQMPTSLLAQVDSSVGGKTGINTAHGKNLVGVFNQPQLVLADTQVLDTLSPREFRAGYAEVAKYGLIDRPDFFAWLEANWQEVFSGGAARTKAIAESCRSKAAVVARDERETGDRALLNLGHTFGHALESATGYDSSRLVHGEGVAIGMALAYRFSARMNLAGIEAAERVEAHLKAVGLPVSLAEVPGGLPPAEKLMDYIAQDKKVTRGTLTFILTHGIGQSFIAKDVPPAAVLEFLKERLAIA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOGA1_EMENI
Sequence: MANRPLVPGVYVPTVAFFAENEDVDVATVEKHAAYLAKSGVAGIVVQGSNGEAVHLDREERNLITSATRHALDSVGATSMPVIVGTGAPSTRETINLCKDAAAAGGDYVLVLPPSYYKSLVSSAALLDHFRAVADASPIPVLIYNFPGASAGLDLSSDDILALSSHPNIIGTKLTCGNTGKLTRIVAQAGPSFLTFGGSCDFTLQTLIGGGAGVIAGTANIIPRACVRIMELYRAGRVEEAQKVQAIVARADWLAIKGGFVAVKSALQSYRGYGQQPRRPCVAPSSEEAAALKEAFSESIELERQLESQ
What is the function of this protein?
Catalyzes the final step in the metabolic pathway of hydroxyproline (By similarity).  Involved in osmoadaptation.
What are the official names of this protein?
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, Dihydrodipicolinate synthase-like, DHDPS-like protein, Probable 2-keto-4-hydroxyglutarate aldolase, Probable KHG-aldolase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: RL17_BRUC2
Sequence: MRHGNGYRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAISAIRDVKLVAKLFDTLAARYATRNGGYIRIMKAGFRAGDNAPLAVVEFVERDVDAKGKADRARVEAEAAAEADAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL21_GEOSM
Sequence: MYAVVKTGGKQYKVSEGDFLKVEKLEGAVGDTVEFSEILMVGGDKVVIGTPLVPSASVVGKIVEQGKDKKILVFKSKRRKNTRKLNGHRQLRTILMIEKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: UH03_RAT
Sequence: SGHTKIKVAVDT
What are the official names of this protein?
Unknown protein from spot P3 of 2D-PAGE of heart tissue.
Protein: METK_XYLFA
Sequence: MSSYLFTSESVSEGHPDKVADQISDAVLDAILVQDPRARVACETMVKTGVAIIAGEITTSAWVDLEALTRKVIVDIGYNSSDVGFDGATCGVLNLIGKQSPDINQGVDRKKAEEQGAGDQGLMFGYATNETDSYMPAAIHISHRLVEQQAKIRKKSNSPLPWLRPDAKAQITLRYEDGVASAIDAVVLSTQHDPGIKQKDLVEAVREEILKPVLPSKWLHKGTKFHINPTGKFVIGGPVGDCGLTGRKIIVDTYGGSARHGGGAFSGKDPSKVDRSASYAVRYVAKNVVAAGLADRCEVQVSYAIGVAEPISISVTTFGTGKISDDKIEKLIRQHFDLRPYGIIKMLDLIHPIYQPSASYGHFGRKPRELAYTNSNGERVVATAFSWEKIDKAEVLRADAKLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM237_HUMAN
Sequence: MRTDSGARLEEGHLRPPRALPPVPSQDDIPLSRPKKKKPRTKNTPASASLEGLAQTAGRRPSEGNEPSTKELKEHPEAPVQRRQKKTRLPLELETSSTQKKSSSSSLLRNENGIDAEPAEEAVIQKPRRKTKKTQPAELQYANELGVEDEDIITDEQTTVEQQSVFTAPTGISQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVALTVHRAFRMIGLFSHGFLAGCAVWNIVVIYVLAGDQLSNLSNLLQQYKTLAYPFQSLLYLLLALSTISAFDRIDFAKISVAIRNFLALDPTALASFLYFTALILSLSQQMTSDRIHLYTPSSVNGSLWEAGIEEQILQPWIVVNLVVALLVGLSWLFLSYRPGMDLSEELMFSSEVEEYPDKEKEIKASS
What is the function of this protein?
Component of the transition zone in primary cilia.  Required for ciliogenesis.
What are the official names of this protein?
Transmembrane protein 237, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein.
What is the protein family that this protein belongs to?
Belongs to the TMEM237 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.
Protein: DHMA_PHEZH
Sequence: MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAYLYRHIIPRLVAAGHRAIAPDLVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLFCQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDGFKAWLQFSQTVPELPIGFLLNGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDKPLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRSR
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: F16PA_LAWIP
Sequence: MSSEVTVTEHLLLQQQRAPQATGHFTSLFHDLILSAKIISRSVNKAGLLDVLGGTGDINIQGEKVQKLDEFADKVLLYRMERSGVLCAMASEEHAELIKVSAAFPRGDYILIFDPLDGSSNIDVNINVGTIFSILRRKPGKTGDVELDEVLQPGSEQIAAGYFLYGTSTMLVYTAGQGVHGFTLDPSVGEFLLSHTDIKIPDEGFIYSVNEGYWDYWDTPTREAVMYFKQPSSKEKVRSARYVGSLVADFHRTLLYGGVFMYPSDNRKGKMHGKLRYLCEASPLAFVAENAGGAATDGLYRTLDYVPLSLHNRVPLVIGSKKDVEAVANIYAKYK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALGL_PSEA8
Sequence: MKTSHLIRIALPGALAAALLASQVSQAADLVPPPGYYAAVGERKGNAGSCPAVPPPYTGSLVFTSKYEGSDSARATLNVKAEKTFRSQIKDITDMERGATKLVTQYMRSGRDGDLACALNWMSTWARAGALQSDDFNHTGKSMRKWALGSLSGAYMRLKFSSSRPLAAHAEQSREIEDWFARLGTQVVRDWSGLPLKKINNHSYWAAWSVMSTAVVTNRRDLFDWAVSEFKVAANQVDEQGFLPNELKRRQRALAYHNYALPPLAMIAAFAQVNGVDLRQENHGALQRLAERVMKGVDDEETFEEKTGEDQDMTDLKVDNKYAWLEPYCALYRCEPKMLEAKKDREPFNSFRLGGEVTRVFSREGGS
What is the function of this protein?
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism.  May serve to degrade mislocalized alginate that is trapped in the periplasmic space.
What are the official names of this protein?
Alginate lyase, Poly(beta-D-mannuronate) lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CSRA_MARSD
Sequence: MLILTRRPGEALYLDDNIKITVLSVQGRQVKLGLEIPAETTVYREEVYLKIKEQNRLALENTEQDLLAATELWQKKEKK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG36_YEAST
Sequence: MASVNNYQVDCGSRSARIQPRINNGIHDEESLFEVLELSEEEFELDFHRLKSFNDVRVINNPDLSPECTNTAISRDETLESASSAFEVPSDEIAILSISSDSNKNSPPSEQPAPALRNIRSSSNSDRIDEWCLGSHLFNELHQNVPQSSDGVNHGFPVYSFKERELYTSAKLKKLTNAQRIAVQKLSRDLYPILRTCYREKTRRQLLTYHHERIFDDIPSFFPQRDFIFNYYSMPLEFDRLSDVDIDSSSRSRFTDESTGETLNRSPSAASSSLENTSWFGWTLLSRFLDREW
What is the function of this protein?
Required for autophagic breakdown of peroxisomes, called pexophagy, through linking peroxisomes to the autophagy apparatus.  Involved in regulation of the glyoxylate cycle.
What are the official names of this protein?
Autophagy-related protein 36.
What are the subcellular locations of this protein?
Peroxisome. Note=Recruited to peroxisomes by PEX3.
Protein: NQRB_PSEA8
Sequence: MGLRNLLDKVEHHFEKGGRYEKWYPLYEAVDTFLYRPGSVTRTTAHVRDGIDLKRMMIIVWLCTFPAMFFGMYNVGHQANLIFAQSPDLLSAQDGWRFALIGALAGFDPNSLWDCLVQGAAYFLPVYLTTFIVGGFWEVLFASIRRHEVNEGFFVTSVLFALTLPPSVPLWQVALGISFGVVLGKEVFGGTGKNFLNPALVGRAFLFFAYPAQMSGDAVWTSVDGFAGATSLSLAAAGGVDNILGHGLTWMDAFLGHMQGSMGETSTLAIFIGGAVLLLTRIASWRIVAGVMLGMVAMSYLFNAIGSASNPMFAMPWYWHLVTGGFAFGMIFMATDPVSASMTDTGKWLFGALIGVMVMLIRVVNPAFPEGMMLAILFANLFAPLIDHFVVQANIKRRLARNG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVG_MYCTU
Sequence: MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA
What is the function of this protein?
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
What are the official names of this protein?
Acetolactate synthase large subunit IlvG, ALS, Acetohydroxy-acid synthase large subunit, AHAS.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.