PharMolix/UniProtQA huggingface dataset:
Protein: SPC29_YEASA
Sequence: MDYSNFGNSASKKFQDDTLNRVRKEHEEALKKLREENFSSNTSELGNKKHYRAQERMSSPLHRLSPTGKSDDRKVKSPLDDKLRRQLREGNTRLPPPPFSSYGMPPTNRSNLDRIRRRTSSPVRTDKFASQNVIDDQRLEIKYLERIVYDQGTVIDNLTSRITRLESFILNSISDRGDKNFASLEHSRSFSGFPTNKTYGLQMGGLYENDMPYRRSSDNINKEGAREDRSSQIHIENESTEDILKNIVFVFSQLN
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity).
What are the official names of this protein?
Spindle pole component 29.
What is the protein family that this protein belongs to?
Belongs to the SPC29 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: TRMB_SINMW
Sequence: MTETRGARATEAFFGRRKGKPLRERQAAHLENLLPELKIDLEHAAPADLKELFPVSVERVRLEIGFGGGEHLIHRAAEDPATGFIGVEPFVNSMAKLLGQIEAKAIRNIRLHDDDATQVLDWLPAASVDQIDLLYPDPWPKRKHWKRRFVSEVNLDRFARILRPGGVFCFASDIDSYINWTLIHCRDHAAFEWTAAGAADWLAPFAGWPSTRYEAKARREGRSSAYLSFRRS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: YJ41_YEAST
Sequence: MYSMAFLASSGLVANSSATVFKLNRALNLLAKTVLPDLLTKMSLSCSRVHSSTFSWKCFSKLVDMFFFFFLAWYVRRTTVYPNLNLELPSNIHVYSLDLPYVIYMIKTFQLIEKNFLSSHAG
What are the official names of this protein?
Putative uncharacterized protein YJR071W.
Protein: SPC24_XENLA
Sequence: MLCEQISEYVDVSREIVKVMVSDSAAGALKKSLDRQEAMIDSLLDTEVQASQLIRDLMAVEEKVAQKLLDTEETKQKSSSKLQKIDRELQERMEKNASLESSIKFLQKDLEELKVMEEEIADMQREADEDTTTVIPSAVYLAKLFHNVTKIDWDYNCDPSLIKGIHYGGDIAQPISIDSNQHSKIFICNYLWSLLSTDW
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735).  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735).  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
What are the official names of this protein?
Kinetochore protein Spc24, xSpc24.
What is the protein family that this protein belongs to?
Belongs to the SPC24 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: RUVA_MYCA1
Sequence: MIASVRGEVLEVALDHAVIEAAGVGYRVNATPSTLSTLRTGTQARLITAMIVREDSMTLYGFTDAETRDLFLTLLSVSGVGPRLAMATLAVHDAGALRQALHDGDVAALTRVPGIGKRGAERMVLELRDKIGAAGAAGAPAGAARNGHAVRGPVVEALVGLGFAAKQAEEATDKVLAAEPEAGTSGALRAALSLLGKSR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: INSC4_ECOLI
Sequence: MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsC for insertion element IS2H.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: EIF3L_YARLI
Sequence: MDSDEEFIDNSLAVGDIVYDEAQIAQQQQEYAAQLKLASTAIPTVVKDFIQYFHRCLSDNSVYELHGCYENSFGKLTDKFYKNSHWPHPVAQVAPLVKNDPVFLYFYSELYYRHLYAKLTPTPLERFESYSNYCNLFNYILNSDGPVDLELPTSWAWGIVDEFIYQYNSYWMTKEAHNSDGVAPDTWGTYSVLNVLYSLSEKTKIREQLRAIKAGLDPMDVAGPYGSRPLYKMLGYFCVIGLLRVHTLLGDFTLALKTMESIELTKKALFARVAPAHFATYYYVGICYVMTRRYADAIRCFSHVLTYMARTKNVQGPRYDAKRSEQMYALLAICVVLSPARLDDSIHVALRDRYGDQMAAMQRGDLKLFEELFTFAAPKFIQPGDVHGGDPLKHHLKIFMVDVTNTLSTANLKSYLNLYATMDLGKLASFLDTDAEDLRSQLVTLKMKNRQLRWTEGELADGTYQHCSELDIALENDLIHVAEAKGGRKFADWFIRNTVKNYSVQDYIVNGDKKDKEKKN
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_BURPS
Sequence: MTNFSSSPPIAFGDLQGCHAAYRQLFDTLAPAADTPLWFAGDLVNRGPASLATLREIVALGERAIAVLGNHDLHLLAVAAGIRTLKPGDTIGEILDAPDADDLIEWVRHRPFAHFERGMLMVHAGLLPQWDAALALELADELQRALRAPNWRDTLRSLYGNDPNCWSPDLKHADRLRVAFNAFTRIRFCTPEGAMEFRANGGPAAAPAGYLPWFDAPGRKTADVTVVFGHWAALGLMLRENLVALDSGCVWGNRLSAVRLADDPAARVVTQVACERCGAADE
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: HCP_ECO27
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_ACIBS
Sequence: MELNPTEKDKLLIFTAGLVAERRKARGLKLNYPEAVAFISAALLEGARDGMTVSELMHFGTTLLKRKDVMDGVPEMIAEVQVEATFPDGSKLVTVHQPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_PSEMY
Sequence: MAQVKRIRRKVDGIILLDKPRGFTSNAALQKVRWLLNAEKAGHTGSLDPLATGVLPLCFGEATKFSQYLLDADKGYETVAQLGVTTTTGDAEGEVLERRPVTVGRPEIEALLPRFRGEIKQIPPMYSALKKDGQPLYKLARAGEVVEREARSVTIARLELLALEGEQARLSVDCSKGTYIRTLVEDLGQLLGCGAHVAELRRTKAGPFELARTVTLEELEAVHAEGGSEALDRFLQPVDSGLQDWPLLQFSEHSAFYWLQGQPVRAPEAPKFGMVRVQDHNGRFIGIGEVSDDGRIAPRRLIYTGA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SYS_UREU1
Sequence: MFDINLIRKDIVVTKEKMLNKKVSSDLFDQIFGLDVLVRNLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNSIKSELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFEPRKFDFSPLAHWDLAAKNKLIDFDKSTKITGSRFIIYTNFGARLYRALQQFCLDMNVKAGFNEIWAPVIVNQESLIGSGNLPKFVDDLFKLENSNYYLSPTAEVQLTNLHRNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRIALCTGDLGFSSAKTYDLEVWLPSYNAYKEISSCSNCTNFQARRAKIRYKETVDAPTELVHTLNGSSLAIDRLWAAVVENYQQEDGSITIPKALEKYIY
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBL19_ARATH
Sequence: MELVHSATFPCKQKLLIAVTIATSLLTIIPLLYPLLEDPNFFLKQQPPSQSSIINLENGVVTSHDSCDIFSGEWVPNPEAPYYTNTTCWAIHEHQNCMKFGRPDTDFIKWKWKPYGCEDGLPVFDPVRFLEIVRGKTMAFVGDSVSRNHMQSLICLLSQVEYPMDASVKNDDYFKRWTYETYNFTIAAFWTPHLVKSKEPDQTQPKHIDIFDLYLDEADESWTADIGDFDFVIISSGHWHYRPSVYYENRTITGCHYCQLPNITDLTMFYGYRKAFRTAFKAILDSESFKGVMYLRSFAPSHFEGGLWNEGGDCLRKQPYRSNETQDETTMKLHKIQLEEFWRAEEEAKKKGKRLRLLDTTQAMWLRPDGHPSRYGHIPEANVTLYNDCVHWCLPGPIDNLNDFLLAMLKREEDKGFLAQVRKMLS
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 19.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RIBBA_BACFR
Sequence: MEPIRLNTIEEAIADFKEGNFVIVVDDEDRENEGDFIIAAEKITPEKVNFMLTHGRGVLCAPITEERCAELELDMQVSSNTSIYETPFTVTVDLLEGCTTGVSMHDRAMTIRALADPKTKPADLGRPGHINPLRARSRGVLRRAGHTEASVDLAKLAGLYPAAALIEIINEDGTMARLPQLVEVARRFGLKIISIKDLIAYRLQMESIVDRGVEVDMPTQFGHFRLIPFRQKSNGMEHIALIKGTWDTDEPILVRVHSSCMTGDIFGSCRCECGEQLHKAMEMIEAAGKGVIVYMNQEGRGIGLMNKIAAYKLQEEGYDTVDANLHLGFDADERDYGVGAQILREIGVKKMKLMTNNPVKRIGLEAYGLEITENVGIEIKPNPYNERYLKTKKDRMGHTLHFNK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: O16O_CONAB
Sequence: VIIIAVLFLTACQLIATASYARSERKHPDLRLSSRNSKLSKRCLGSRELCVRDTSCCSMSCTNNICF
What are the official names of this protein?
Conotoxin AbVIO.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACYP_STRCO
Sequence: MSEDVRLVAWVRGQVQGVGFRWFTRARALELGGMSGFALNLGDGRVQVVAEGPRERCEGLLEWLRGDDTPGRVDGVTEIWDTPRGGYEGFAIR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: MOBD_BPT4
Sequence: MNYTKVYNNLIKKGKLRKLDKSKLNFYTEKHHIIPSCIGGNDDSDNLVLLTAREHFIAHWLLAKIHYNSPGLIYAWWSFYNFGEDSLGRNLKLTSRGYQLVREKFSKIHSNTMKEMWKSNEYREKRSITLSLPEIRAKISESQLEAQNKPEVKEKISKGVKAAFKRPGVKEKHSAAVKKSLNNFEAKKKQSNSSKIRQRTGKHWQDYDLLYKLWIKLNRPKRGSFGTYISKLGYPKSNYHRLIVQFNEDYERSNNENCS
What are the official names of this protein?
Probable mobile endonuclease D.
What is the protein family that this protein belongs to?
To phage T4 mobB and mobC.
Protein: LSPA_MYCPN
Sequence: MAKAPTFFSKLLKQILFANRKPFLYYKLALILFVGFVILFQVFMLRAALNGEKGINGANGTDVARSSFISIYVIGNKGVGFSLLADQPGLVYFLQGFLSFIALFFLVFSTSYNYIFWITTLAFGSLGNFFDRLTSGSGEVLDYFVFSGGNSVFNLADCCITFSFIGLFLSFLIQFFKEMKQTKS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HFQ_AROAE
Sequence: MSNKGQLLQDPFLNTLRREHVPVAIYLVNGIKLQGQIESFDQYVVLLKNTVTQMVYKHAISTVVPARPVNIQQQDSGEGNS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: NEPS2_NEPRA
Sequence: MGNKKTLEGKVAIVTGGASGIGETAARVFANLGARAVVIADIQSELGREVAESIGAKRCSYVQCDIGDEEQVKSMVEWTATTYGALDVMFCNAGIMSKAESAQTVLELDMSKFDEVMRVNTRGTSACVKQAARKMVELGTKGGAIVCTSSPLASRGGYIDTDYVMSKHAVMGLVRSASMQLGAHGIRVNSVSPMAVLTPLTRRMGLATPADVENAFGRFTSLKGVALTAEHVAEAAAFLASDEAAFITGHDLMVDGGLLCLPFFAPTS
What is the function of this protein?
Functions as a non-oxidoreductive cyclase to promote the formation of cis-trans-nepetalactol (PubMed:30531909, PubMed:30664302).  Cis-trans-nepetalactol is then oxidized by NEPS1 into cis-trans-nepetalactone, which belongs to a family of metabolites that are both insect-repellent and have euphoric effect in cats (PubMed:30531909, PubMed:30664302).  Binds NAD(+) as classical short-chain dehydrogenase/reductase (SDR), but does not utilize it for its redox-neutral cyclase activity (By similarity).
What are the official names of this protein?
(+)-cis,trans-nepetalactol synthase NEPS2, Nepetalactol-related short-chain reductase 2, NmNEPS2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MOAC_ECO27
Sequence: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIIDGRHHKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAEPEHNRVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVEADD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: UBIA_ECOSM
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: F16PA_AZOVD
Sequence: MSRVTLSRYLIEQTRSHNTPADLRFLIEVVARACKEISHAVSKGALGGVLGSMGTENVQGEVQKKLDVMSNEILLEANEWGGHLAGMASEEMDSAYQIPGKYPKGAYLLVFDPLDGSSNIDVNVSVGTIFSVLRCPDQYLTQNDSLNEQAFLQPGTQQVAAGYAIYGPQTMLMLTLGNGVKGFTLDRELGSFVLTHDNLCVPETTAEFAINMSNQRHWEPPVKRYVDELLAGKTGPLDKDYNMRWIASMVADVHRILTRGGIFMYPRDAREPSKPGKLRLMYEANPMSFIIEQAGGAATNGTQRILDIQPESLHQRVAVFLGSKAEVERITDYHLEG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTU_SHESR
Sequence: MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLKRLEDDETLMVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHFGGVAAGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLLANAADVFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKASMAVQVQAMLDLQAAGAATLDYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARLAQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMLKD
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SH22A_MOUSE
Sequence: MEFCLAQPCPQGNHEATSSTFNTFQPMNLTQGRCQNLSCGSRPSMQVMKEQGVQLSPRTNHTVVSASAPGTAWVLGNADRAEEVPGKGDLSLQAETRAWVQKTQAHWLLLKTAPLWFHGFITRREAERLLQPQPLGCYLVRFSESAVTFVLSYRSQTCCRHFLLAQLGDGRHVVLGEDSAHAQLQDLLEHYTECPLSPYGEILTQPLARQTAEPAGLSLRADSDSGSKRQDPDTQLSLLLQQGQAQASGHTEKVWASQQKATSQASRPRPPIPAKPQLPPEVYTSPASRLHQAPPINPIYQEPDEPIAFYAMGRGSPGDAPSNIYAEVEGPSGTAPIGHPILRKCWSRPISRGQVREVQGKISSRSRAERGSPS
What is the function of this protein?
Could be a T-cell-specific adapter protein involved in the control of T-cell activation.  May play a role in p56-LCK-mediated T-cell signaling.  Could be involved in the regulation of responses to T-cell activation stimuli, specifically proliferation and lymphokine production.  Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery.
What are the official names of this protein?
SH2 domain-containing protein 2A, Lck-associated adapter protein, Lad, Rlk/Itk-binding protein, Ribp.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Redistributed from cytoplasm to the plasma membrane in a T-cell activation-dependent manner.
Protein: EF2KT_MOUSE
Sequence: MAPEDHEGATSLLQSFERRFLAARALPSFPWQSLEEKLKDPSGSELLLAILQRTVKHPVCVQHGPSVKYARCFLSKLIKKHEAVPTEPLDALYEALAEVLMTQESTQCHRSYLLPSGNSVTLSESTAIVSHGTTGLVTWDAALYLAEWAIENPAAFTDRTILELGSGAGLTGLAICKACCPRAYIFSDCHAQVLEQLRGNVLLNGFSLEPHTPIDAGSSKVTVAQLDWDEVTASQLSAFQADVVIAADVLYCWEMTLSLVRVLKMLEDCQRKSAPDVYVAYTIRSQDTGKLFIEELDRAGIYWEEVPPHTGKLFPYEEHSAIVILKLVLTSRHGV
What is the function of this protein?
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
What are the official names of this protein?
Protein-lysine N-methyltransferase EEF2KMT, eEF2-lysine methyltransferase, eEF2-KMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_BURM7
Sequence: MKVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRRGGASWSKAENAGLAVKEVAEAVKGADVVMMLLPDEQIAAVYAQEVHANIKEGAALAFAHGFNVHYGQVIPRADLDVIMVAPKAPGHTVRGTYAQGGGVPHLIAVAQDKSGAARDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGSKLRAMMPWIAKNKLVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SSRP_ACIAD
Sequence: MSKAVVVKKNNGGTIAQNKRARHDYFIEEKFEAGMSLQGWEVKSLRAGRMSLTESYIIFKNGEAYLFGAQIQPLLTASSHVVPEATRTRKLLLSRREIGQLLGAVNQKGYSCVPLACYWKGHLVKLEIALVKGKQLHDKRATEKDRDWQRDKARIMHK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: WHAL1_HUMAN
Sequence: MMILVFWSNYPYEPVCLASHRNNMEASVPKYKKHLPQLGMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNINVVDELAIQFYEIQLELYEVKFEILKNKEILLTTQLDSLERLIKDEI
What are the official names of this protein?
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1, WAS protein homolog associated with actin, Golgi membranes and microtubules pseudogene 3, WAS protein homology region 2 domain-containing protein 1-like protein 1, WH2 domain-containing protein 1-like protein 1, WHDC1-like protein 1.
Protein: NPBW1_MOUSE
Sequence: MHNLTLFESGGDNVSCGGSSLGCPNGSSLAPLPLPQPLAVAVPVVYGVICAVGLAGNSAVLYVLLRTPRMKTVTNVFILNLAIADELFTLVLPINIADFLLRRWPFGEVMCKLIVAVDQYNTFSSLYFLAVMSADRYLVVLATAESRRVSGRTYGAARAVSLAVWALVTLVVLPFAVFARLDEEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVTTICALYTTLLCRLRAIQLDSHAKALDRAKKRVTLLVAAILAVCLLCWTPYHLSTIVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLVSCRSA
What is the function of this protein?
Interacts specifically with a number of opioid ligands.  Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).
What are the official names of this protein?
Neuropeptides B/W receptor type 1, G-protein coupled receptor 7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.