PharMolix/UniProtQA huggingface dataset:
Protein: NPDC1_HUMAN
Sequence: MATPLPPPSPRHLRLLRLLLSGLVLGAALRGAAAGHPDVAACPGSLDCALKRRARCPPGAHACGPCLQPFQEDQQGLCVPRMRRPPGGGRPQPRLEDEIDFLAQELARKESGHSTPPLPKDRQRLPEPATLGFSARGQGLELGLPSTPGTPTPTPHTSLGSPVSSDPVHMSPLEPRGGQGDGLALVLILAFCVAGAAALSVASLCWCRLQREIRLTQKADYATAKAPGSPAAPRISPGDQRLAQSAEMYHYQHQRQQMLCLERHKEPPKELDTASSDEENEDGDFTVYECPGLAPTGEMEVRNPLFDHAALSAPLPAPSSPPALP
What is the function of this protein?
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation.  Might be involved in transcriptional regulation (By similarity).
What are the official names of this protein?
Neural proliferation differentiation and control protein 1, NPDC-1.
What is the protein family that this protein belongs to?
Belongs to the NPDC1/cab-1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PTR9_CAEEL
Sequence: MKSLNFQSVVSQFFEYESTVVVRWPLPFIIIPPLLTFSIVTLTVTNFHLNVTNDTLQVFLPDDMRSLRDLKELLRLFPPRDAQRDTYSIFGSKFVYTVIEDDSSDGNILSSSGIQRMSKLHKFVMGLETSLGDNVASNCLRNKDDEACTMHPIAFALEDTTPEFAIQFLLRYPNLKFGDFVIDNAMVFGDVRIEPKSQDRDGNSPIRSSKAVRMTYILESSESTERWIDLFLSAIPRYKETNSTIFWSSSKSLAKEMERNGELLIPWMPWTSLVLVVFCMFACSSLNIVKSQPFIGFFAMFNATMATIASTSLLLYLQYPFLPLVFIMPFLVVSIGTDNMFLMLKSWRMTKKSSNEEQRYIHALTESAASLFLTSLTDGLSFAIGSISDFHAVRVFCTYCAMAILFMFLFQVTFFNAVMSLCCRREVSGKHPVFCCYEITPPEETQVLEKQSNFDFSSIVAKHLFKILNPLPSRIGVFFIFLAYLFISIHFAIGLPLGLDLKLLAPDDSYVSKELEAQERLFADYGGFCFALVRAENISLKDPMVRRNLIGLYRDLGGSEYSSPSEFWLDPFEKKNRGKKYSESDFSDELHTFLAKEPHLKFRNDIRFTMMGKIEAMKMMFRVRKLGKDNDAPRAEYMRKVMENSQFNGFVYDTSFLLVDQQMTTVYNVIVDVVSAILTMLSICVLMVPRPVSAMCIAFAILSVNIGVIGALAATNTRLDIISMITIVMSVGFSVDYVTHTTFHFVIQRDNRLEKCLLVMTEPILQSALSTAIGVSLLSFVHSYIVRTFVNTVFFVVGLGILHGLIFLPVLLDTIVPDSEYMVPYEPQHEDEENPNHYEDLYGL
What are the official names of this protein?
Patched-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the patched family.
Protein: RIB7_METJA
Sequence: MVMVMEKKPYIISNVGMTLDGKLATINNDSRISCEEDLIRVHKIRANVDGIMVGIGTVLKDDPRLTVHKIKSDRNPVRIVVDSKLRVPLNARVLNKDAKTIIATTEDTNEEKEKKIKILEDMGVEVVKCGRGKVDLKKLMDILYDKGIKSILLEGGGTLNWGMFKEGLVDEVSVYIAPKIFGGKEAPTYVDGEGFKTVDECVKLELKNFYRLGEGIVLEFKVKK
What is the function of this protein?
Catalyzes an early step in riboflavin biosynthesis, the NAD(P)H-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.  The beta anomer is the authentic substrate, and the alpha anomer can serve as substrate subsequent to spontaneous anomerization.  NADPH and NADH function equally well as the reductants.  Does not catalyze the reduction of 5-amino-6-(5-phospho-D-ribosylamino)uracil to 5-amino-6-(5-phospho-D-ribitylamino)uracil.
What are the official names of this protein?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, DAROPP reductase, DARP reductase, 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase, DARIPP synthase, MjaRED.
What is the protein family that this protein belongs to?
Belongs to the HTP reductase family.
Protein: HAT14_ARATH
Sequence: MELALSLGDNTKKQFSFMEKNSKINNPSVSSTSTSEKDLGFCMALDVAFGGHRSLSSSSSPSVEDEKKKPAPRAKKSDEFRVSSSVDPPLQLQLHFPNWLPENSKGRQGGRMPLGAATVVEEEEEEEEAVPSMSVSPPDSVTSSFQLDFGIKSYGYERRSNKRDIDDEVERSASRASNEDNDDENGSTRKKLRLSKDQSAFLEDSFKEHSTLNPKQKIALAKQLNLRPRQVEVWFQNRRARTKLKQTEVDCEYLKRCCESLTEENRRLQKEVKELRTLKTSTPFYMQLPATTLTMCPSCERVATSAAQPSTSAAHNLCLSTSSLIPVKPRPAKQVS
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein HAT14, Homeodomain-leucine zipper protein HAT14, HD-ZIP protein 14.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class II subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_RUMCH
Sequence: MRLPQDIIIKPYITEKSNMEIGAGKYTFIVDVKSTKTEIKKAVEALFSVKVLQVNTMNFEGKVKRTGVHEGPRPAWKKAVVKIDTDPKPVEYLAKGGKTVTNNKKYKTSIEEFGVAQ
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ACO1_ARATH
Sequence: MASENPFRSILKALEKPDGGEFGNYYSLPALNDPRIDKLPYSIRILLESAIRNCDEFQVKSKDVEKILDWENTSPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSNAFHNMLVVPPGSGIVHQVNLEYLARVVFNTNGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLTGKLRDGMTATDLVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATIANMSPEYGATMGFFPVDHVTLQYLRLTGRSDDTVSMIEAYLRANKMFVDYSEPESKTVYSSCLELNLEDVEPCVSGPKRPHDRVPLKEMKADWHSCLDNRVGFKGFAVPKEAQSKAVEFNFNGTTAQLRHGDVVIAAITSCTNTSNPSVMLGAALVAKKACDLGLEVKPWIKTSLAPGSGVVTKYLAKSGLQKYLNQLGFSIVGYGCTTCIGNSGDIHEAVASAIVDNDLVASAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFETQPIGTGKDGKQIFFRDIWPSNKEVAEVVQSSVLPDMFKATYEAITKGNSMWNQLSVASGTLYEWDPKSTYIHEPPYFKGMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRRDFNSYGSRRGNDEIMARGTFANIRIVNKHLKGEVGPKTVHIPTGEKLSVFDAAMKYRNEGRDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVISKSFERIHRSNLVGMGIIPLCFKAGEDAETLGLTGQELYTIELPNNVSEIKPGQDVTVVTNNGKSFTCTLRFDTEVELAYFDHGGILQYVIRNLIKQ
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.  Contributes to oxidative stress tolerance (PubMed:17013749).  May have a role in respiration (PubMed:25061985).
What are the official names of this protein?
Aconitate hydratase 1, Aconitase 1, Citrate hydro-lyase 1.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: RRF_BDEBA
Sequence: MAIADVKKNAQAKMEKTLNSLSEELKKVRTGRAQVSMLDGIRVNYYGTPSPLSQVASISTPDAKSFLIAPWEVAILKDIEQAIIKSELGMAPMNDGKVIRLKVPDLTEERRKDLAKQVKKIAEEARVAVRMARRDANDEVKKLQKDKAVSEDEGKKAEADIQKVTDDFIKKVDQVAEEKEKAILTI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_SALPB
Sequence: MMENFKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAQTINDPRFSIIHGPFSALADYVAERELTGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTFGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLSVLAPGGRLSIISFHSLEDRIVKRFMREQSRGPQIPAGLPMTEAQLKKLGGRELRALGKLMPGEKEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1449_METPP
Sequence: MDSASDAGERRPARAALRVLSLIEQRVVAVLVEKQHTVSDSYPLSLNTLLLGCNQKTAREPVINATESEVLAAVDELKRLSLVIEVSGSRVARYEHNLQRVLGVPSQAAAILTLLMLRGPQTAAELRANTERLHRFADISSVEGFLDELALREPPLVVKLPRAPGSREARWAQLLGGPPEVSVAAPAGAAPEDLVTAGEIQALRANQHRLQAEVVMLRAQLHRLAAELGVDLS
What are the official names of this protein?
UPF0502 protein Mpe_A1449.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: RSXD_ECOSM
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQVIFSGHITSGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEQIMQYPIYSGMLAGVGWQWVNLAWLAGGVWLLWQKAIRWHIPLSFLVTLALCATLGWLFSPETLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAK6_PONAB
Sequence: MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSTMPMDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRRGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
What is the function of this protein?
Serine/threonine protein kinase that plays a role in the regulation of gene transcription.  The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6.  Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription.  Inhibits also ESR1-mediated transcription.  May play a role in cytoskeleton regulation by interacting with IQGAP1.  May protect cells from apoptosis through phosphorylation of BAD (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 6, p21-activated kinase 6, PAK-6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Protein: HISZ_ALKCK
Sequence: MSEPFMFEKPLGMRDVLPNLHSMQRKLGDRVLQEFRLWGYEQVQTPTLEYYETVGKASAISDKQLFKLIDFHGNTLVLRPDMTAPIARLVSSSMKDIPYPLRLSYCSSLYRALQTEGGRPAEFAQVGVELVGDHTASADGEMLLLLNRALIQAGLDHFQVAVGHIGFLNALFLEIFGTVERAELLRRQLYEKNDVGFKEQVKAFGLSSIDEKKLLKLSRLRGNEAILAEAEQLTESAEGKQAVAELRDLWQGLKEGGLTRYMKLDLSLVLHMSYYTGCIFEVYHDRLPRPLGGGGRYDHLLAKFGRPGPATGFGLRLDLLAEAVGKLEVQPKKRCLLYSRERRQEAYRKATALREKGMQVVLQDVAGVDDIDKMSASYEEIVYLIGKTEEGKR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOGL2_ARATH
Sequence: MERSSSYGVEKLQKRCYHEWMSLQTKHIDDLKEALMCQRNNDDKLEDLVGKIVNDYHTYAGKRSELSYRCCAHYFAPSWNTPIENSMLWMGGCRPSSFIRLIYALCGSQAETQLSQYLLKIDDDFDINHGGFMSDLTATQLGKLNDLHLEVIKKEDKITKTSANFQDDVADLPIADVVHADVAVEDALDKHEEGMAVLLAEADKLRFETLRKIVDVVTPLQAVEFLLAGKRLQLSLHDRGRVRADVCGGVGGAAV
What are the official names of this protein?
Protein DOG1-like 2.
Protein: SRRT_DROMO
Sequence: MADSDDEYDRKRRDKFRGERDSYRPERRDERRPMGGAANSRDEWSERNPFRGSSAAGGGGGGGGARHRPDYSDYRGSGPRARYGSPGREMPPAKRMRPDWGDSEMRSNPRFGYDPYLVQAWNDHYQSLHSAYSHAGHGPSVRETGPAGGGGVSGDTQTQPAMLTLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVRRSEEQRGFLKRRTEVFLELLENGTIGSVKVDSSQADALVRVLDTCVIKLEGGTDEDLKILDEKPKDPPIVYERKSETTESAVVAKREPESPKTEKDDDLPGASSPQHKSLRPVNLDEENWDEDEPMEVHPQTGKDGEKSDDRRSKEPEDEESVKSDNEKKLKKKKIKKRKRNSSDDDSSSSSSSDSDTESDDEKVKAKYDVEEGLRADQKAEALKDKEEAATAAKEKLLAPESPQPEDVVDPKEALEIKSEASEESKQDKTEQPVGQTERPTTDNPAEKNGEEEGAKAEDKPEAGTQESTANEVTETIDLDKVKDGPHPRALHRTSSIFLRNLAPSITKAEIEAICKRFSGYLRVAIADPLVERRWYRRGWITFTRDVNIKEICWSLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQIVRADIKLCAKIAMNLDDRFKLWCDSNRSDAEDAEKKAGQEATNGSGASSSPSYGFNSKNPVLQNITDYLIEEASAEEEELLGLAGDNKDGDGEPIERDESLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPAPMRVTSNDVQEYIKAYDGKLQQFLTKTVQLSDEEIKELGAKNPETEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVEEVRKEVQYFNNYLRDPKRPQLPEHPGSSKRTESESGRGSGYRPPMYPPFSAMPYGFAPPMMGGGGRGGRNFPPVRREMPLEHQRRIIGYHDLDAPINSDMFD
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi).  Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIFK_NATPD
Sequence: MSQTTERVGADELSTLKLVALDGALDGRVTVTCADLADRLDASNQTASRRLQRLEAAALVERDMTGEGQRIAVTEAGERALQREYADYRRLFEGDADVTLSGVVTSGMGEGRHYISLSGYMRQFRERLGYEPFPGTLNVDLDDGSVRTRARMDALDPVKIDGWEDDERTYGPAFCWPAVLETADGDRYGTAHVIAPERTHHGDDQLEIIAPEKLRETLSLDDGDTLSIHVSE
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: AH4_TOXGO
Sequence: EFQEEIKEGVEEHKHEDDPEMTRLMVTEKQESKNFSKMAKSQSFSTRIEELGGSISFLTETGVTMIELPKTASEHDMDQLLHDILAAVESLGSTPR
What are the official names of this protein?
Antigen H4.
Protein: BR1B_NIDOK
Sequence: FFPFVINELAKLPSLISLLKK
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-1OKb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: SCRT1_HUMAN
Sequence: MPRSFLVKKVKLDAFSSADLESAYGRARSDLGAPLHDKGYLSDYVGPSSVYDGDAEAALLKGPSPEPMYAAAVRGELGPAAAGSAPPPTPRPELATAAGGYINGDAAVSEGYAADAFFITDGRSRRKASNAGAAAAPSTASAAAPDGDAGGGGGAGGRSLGSGPGGRGGTRAGAGTEARAGPGAAGAGGRHACGECGKTYATSSNLSRHKQTHRSLDSQLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGAGGPAAPAPPQLSPVQA
What is the function of this protein?
Transcriptional repressor that binds E-box motif CAGGTG.  Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.
What are the official names of this protein?
Transcriptional repressor scratch 1, Scratch homolog 1 zinc finger protein, SCRT, Scratch 1, hScrt.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AKH1_LOCMI
Sequence: MVQRCALVVLLVVAVAAALCSAQLNFTPNWGTGKRDAADFADPYSFLYRLIQAEARKMSGCSN
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic prohormone type 1.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVB_KORVE
Sequence: MIASVGDSRYYPKSVANGEKSDQRERLVSAIPVEDDSSFELKLRPQWLREFIGQPKVKENLAVAIEAARSRGEALDHVLLYGPPGLGKTTLANIIANEMQAQFQQTSGPTLQIKGDLTAILTNVRDKQVLFIDEVHRLQPALEELLYSAVEDYKLDIIIGQGPSARTHTIDVAPFTLVAATTRAGLLSAPLRSRFGIVLRLEFYTTEDLKIILKRSAEILNVEIDEGGAAEIATRCRGTPRIANRLLRRVRDYAQVRGAGKIDRETAQKALEMLEVDQHGFDEVDRRLMLTIIEKYQGGPVGLNTLAASLAEETDAIEEIYEPFLIQLGFLDRTPRGRVATHLAYEYFKMKPPKKQDSLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LRFN5_MOUSE
Sequence: MEKFLFYLFLIGIAVRAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQTVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNASSSNGDTKMSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLASGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQMQGCSVTLPQSMSKQAMGHEENAQCCKVASDNAIQSSETCSSQDSSTTTSALPPTWTSSAPVSQKQKRKTGTKPSAEPQSEAVTNVESQNTNRNNSTALQLASCPPDSVTEGPTSQRAHTKPNALLTNVDQNVQETQRLESI
What is the function of this protein?
Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner.  Promotes neurite outgrowth in hippocampal neurons (By similarity).
What are the official names of this protein?
Leucine-rich repeat and fibronectin type-III domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the LRFN family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: H2A_COCIM
Sequence: MTGGKSGGKASGSKSSQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVMPYIHQNLLPKKTPKTGKNPSQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RRF_PARMW
Sequence: MSTQDLEASMRKSVEATQRNFNTIRTGRANSSLLDRISVEYYGAETPLKSLATLSTPDSQTIQIQPFDISALASIEKAIAMSELGFTPNNDGKIIRINVPPLTEERRKEFCKLASKYAEEGKVALRNLRRDAIDKVKKQEKDGDFSEDQSRDEQDAVQKTLDKFIAELEKHLADKEADILKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_CHLFF
Sequence: MRSQLSLMGKKEGMIHVFDKDGNLVACSVISMSPNVVSQIKVDSTDGYNAIQMGADEISVPEKTLQKRVNKPILGHFKKSGSRVFRTLKEVRVSEDAVNEASLGSEFGLEVFEDVSSVDISGVSKGKGFQGVMKKFGFRGGPKTHGSGFHRHAGSIGMRSTPGRCFPGSKRPSHMGAVNVTIKNLEVIKIDLEKKVLLVKGAIPGPRGSVVVVRRSSRAKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RNY_GEOTN
Sequence: MGSIIISALLALVIGAVVGFFVRKSIAEAKIGGAKAAAEQLIEEAKRAADALKKEALLEAKDEIHKLRTEAEHDIRDRRSELQKQENRLMQKEENLDRKDEALNKREALLEAKEEALNERQQHIEQMESKVETLIKQQQTELERISGLTRDDARHLILERVEKELSHEIAMMVKEAETRAKEEADKRAKAILSLAIQRCAADHVAETTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQDGRIHPARIEEMVGKARREVDEHIREVGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQNVLKHSVEVAFLAGLMAAELGEDEMLARRAGLLHDIGKAIDHEVEGSHVEIGVELATKYKEHPVVINSIASHHGDTEPTSVIAVLVAAADALSAARPGARSETLENYIRRLEKLEEIAESYEGVEKSYAIQAGREVRIMVKPDMIDDLEAHRLARDIRKRIEEELDYPGHIKVTVIRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PADI6_HUMAN
Sequence: MVSVEGRAMSFQSIIHLSLDSPVHAVCVLGTEICLDLSGCAPQKCQCFTIHGSGRVLIDVANTVISEKEDATIWWPLSDPTYATVKMTSPSPSVDADKVSVTYYGPNEDAPVGTAVLYLTGIEVSLEVDIYRNGQVEMSSDKQAKKKWIWGPSGWGAILLVNCNPADVGQQLEDKKTKKVIFSEEITNLSQMTLNVQGPSCILKKYRLVLHTSKEESKKARVYWPQKDNSSTFELVLGPDQHAYTLALLGNHLKETFYVEAIAFPSAEFSGLISYSVSLVEESQDPSIPETVLYKDTVVFRVAPCVFIPCTQVPLEVYLCRELQLQGFVDTVTKLSEKSNSQVASVYEDPNRLGRWLQDEMAFCYTQAPHKTTSLILDTPQAADLDEFPMKYSLSPGIGYMIQDTEDHKVASMDSIGNLMVSPPVKVQGKEYPLGRVLIGSSFYPSAEGRAMSKTLRDFLYAQQVQAPVELYSDWLMTGHVDEFMCFIPTDDKNEGKKGFLLLLASPSACYKLFREKQKEGYGDALLFDELRADQLLSNGREAKTIDQLLADESLKKQNEYVEKCIHLNRDILKTELGLVEQDIIEIPQLFCLEKLTNIPSDQQPKRSFARPYFPDLLRMIVMGKNLGIPKPFGPQIKGTCCLEEKICCLLEPLGFKCTFINDFDCYLTEVGDICACANIRRVPFAFKWWKMVP
What is the function of this protein?
Catalyzes the deimination of arginine residues of proteins (By similarity).  In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity).  May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678).
What are the official names of this protein?
Protein-arginine deiminase type-6, Peptidyl arginine deiminase-like protein, Peptidylarginine deiminase VI, hPADVI, Protein-arginine deiminase type VI.
What is the protein family that this protein belongs to?
Belongs to the protein arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development.