PharMolix/UniProtQA huggingface dataset:
Protein: ES16_MANSE
Sequence: MLFYITVTVLLVSAQAKFYTDCGSKLATVQSVGVSGWPENARECVLKRNSNVTISIDFSPTTDVSAITTEVHGVIMSLPVPFPCRSPDACKDNGLTCPIKAGVVANYKTTLPVLKSYPKVSVDVKWELKKDEEDLVCILIPARIH
What are the official names of this protein?
Ecdysteroid-regulated 16 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NADK_BURO1
Sequence: MKTGNQFKTVALVGRSNTPGIAEPLATLADSIATLGFEVVFEGDTAREIGIAGYPALTPAEIGARADVAIVLGGDGTMLGIGRQLAPYRTPLIGINHGRLGFITDIAASDMQALVPVMLAGKFEREERSLLEARIVRDGEPIYHALAFNDVVVNRSGFSGMVELRASVDGRYMYNQRSDGLIVATPTGSTAYALSSAGPILHPQLAGVVLVPIAPHALSNRPIVLPDDSKIAIQIVGGRDVNVNFDMQSFTSLELNDTIEVRRSKHTVPFLHPIGYSYYTTLRKKLHWNEHASNEDDKAS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
Protein: BTG3_PIG
Sequence: MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTLILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENEEENKDEISKKVTRALDKVTSDYHSGSSSSDEETSKEVEVKPNSVTATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGNGHQNHYPPPVPFGYPNQGRKNKPYRPIPVTWVPPPGMHCDRNHWINPHMLAPH
What is the function of this protein?
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
What are the official names of this protein?
Protein BTG3, BTG family member 3.
What is the protein family that this protein belongs to?
Belongs to the BTG family.
Protein: GOSR1_CAEEL
Sequence: MSETWEALRKKARSTENSIDVKLVSLNKLTASSHGGFDIDEKTVSSRQTSFKTVTTEIEGLIEQLTNINDDMNDVAGAQSSASWANNPAIQHTLRRHREILRDYGSEYRRARDNVDQVLQRELLLSSSNENRNNPILNNRARGYDMYLKENDHINACDRLLDEQLEMAMSTKENMARQGINLRGISTRLHHISKKYPAINNLMQKIKTKKQKNTLILAAVISSCLIFTIFWIIN
What is the function of this protein?
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport.  It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.  Cooperates with ykt-6 for proper expression of Golgi-resident proteins.  Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation.
What are the official names of this protein?
Golgi SNAP receptor complex member 1, 28 kDa Golgi SNARE protein, GOS-28.
What is the protein family that this protein belongs to?
Belongs to the GOSR1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type IV membrane protein.
Protein: O16B_CONAB
Sequence: VIIIAVLFLTACQLTTAETSSRGKQKHRALRSTDKNSKLTRGCTPPGGACGGHAHCCSQSCDILASTCNA
What are the official names of this protein?
Conotoxin AbVIB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SPRC_COTJA
Sequence: MRAWIFFLLCLAGKALAAPQEALPDETEVIEDVTTEEPVGANPVQVEVGEFEEPTEDVEEIVAENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPATSGVFEKVCGTDNKTYDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKFIPPCLDTELTEFPLRMRDWLKNVLITLYERDEDNNLLTEKQKLKVKKIHENEKRLEAGDHTVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDNDKYIALEEWASCFGIKEKDIDKDLVI
What is the function of this protein?
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines.  Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes.  There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
What are the official names of this protein?
SPARC, Osteonectin, ON, Secreted protein acidic and rich in cysteine.
What is the protein family that this protein belongs to?
Belongs to the SPARC family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.
Protein: RSPO3_DANRE
Sequence: MQLQLISIVLILHFMEYTNCQHHGSRHRGNKQVSGVSSQGCQGGCQTCSVYNGCLTCKPKLFIHLERDGMRQIGVCLASCPNGFYGTRSPDRNDCIKCGSECDSCFNRNFCLRCRAGSYLHKGKCMESCPDGLVPSDTKKECVAACPALCDLCQNSDTCTRCVPGHFLHAGQCHHVCPDEFEPNDSMECIPTVHCEVSEWSEWGTCSRSGKTCGFKWGEETRTRKVLQNPSPMGSPCPPTSEKRECFVKKKRCKPPKGQRRGEKKKRFNLQEKVTAEARRERKREREKETIDREESENRNKTEQRRRRDQSRDAGTV
What is the function of this protein?
Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis.  Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  Acts both in the canonical.  Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway.  Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).  Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).
What are the official names of this protein?
R-spondin-3, Cabriolet, Roof plate-specific spondin-3.
What is the protein family that this protein belongs to?
Belongs to the R-spondin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_MICAN
Sequence: MARTPTRLLIAASGTGGHLFPALALAERLPDYEIEWLGVPDRLEQSLVPKTYPLHTIPIEGFQTRLGLKTLKILFSQLRAIWQVRSLIKKRQIAAVFTTGGYIAGPTILAARLANIPVILHESNYIPGKVTKVLGRWCDTVALGFQGTASYLPGTRTTWVSTPVREQFLIPQSLDLPIPETAFLIVVAGGSQGAVALNQLVRQSAPQWLEKGIYIVHLTGENDPEADSLRHSNYFSQPFYDNMAGLWQRANLAISRSGASTLTELAITCTPSILIPYPFAAEDHQFYNAQVFAEAQAAYLYRQNELTAQFLSELVLDLWSNPEKLAAMAQQASHLAISDSADLLADLLRRKSQKDSF
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRUB_THEKO
Sequence: MARDEVRRILPADIKREVVVKDEKAETNPKWGFPPEKRPIEMHIQFGIINLDKPPGPTSHEVVAWVKRILNLNKAGHGGTLDPKVSGVLPVALERATRVVQALLPAGKEYVALMHLHGDVPEDKILAVMREFQGEIIQRPPLRSAVKRRLRTRKVYYIDVLEIEGRDVLFRVGVEAGTYIRSLIHHIGLALGVGAHMAELRRTRSGPFKEDETLVTLHDLVDYYHFWKEDGVEEYFRKAIQPMEKAVEHLPKVWIRDSAVAAVTHGADLAVPGVVKLHKGIKKGDLVAIMTLKDELVALGKAMMTTGEMLQKSKGIAVDVDKVFMPRDWYPKLWKEKE
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: ENGB_ENTFA
Sequence: MNVHNAEIVISAVSPKQYPESQLPEIALAGRSNVGKSSFINTLINRKNLARTSGKPGKTQTLNFYLIEDALHFVDVPGYGYAKVSKTERAKWGKMIETYITQREQLRAVVSLIDLRHPPTQDDIQMYEFLKYYDLPVIIVATKADKIPRGKWNKHESVIKKALNFDKQDDFIIFSSETKEGKEAAWTAIEKFL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: EFTS_PSEE4
Sequence: MAAITAALVKELRERTGEGMMDCKKALEKAGGDIEKAIDDMRASGAIKAAKKAGNVAAEGAIAVKTDGKAAVLLEVNSQTDFLALQDDFKNFVAESIEEAFAQKLTDAAPLIASRESAREALVAKCGENVNIRRLVRVEGDVVGAYLHGNKIGAVVVLKGGDVELAKNIAMHVAASNPEFLDASEISAEAIEREKNVFLQLNADKIAGKPENIVENMINGRITKFKAEASLKEQAFVMNPEVKVGELAKKAGAEIVSFTYFKVGEGIEKPVDNFAEEVAAQVAAAKQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMP1_PARCM
Sequence: MGPMKVLLVLLVVMVAAPHIADAWQQPSCSSICDYSCGKSACISYSGRCGCCASCRRGPIYG
What is the function of this protein?
Has weak antibacterial activity, mainly against marine Gram-positive bacteria like C. maltaromaticum (MIC=200 uM), C. mobile (MIC=100 uM), C. divergens (MIC=200 uM) and C. funditum (MIC=200 uM) but also against C. glutamicum (MIC=50 uM).  Has very little or no activity against Gram-negative bacteria.
What are the official names of this protein?
Paralithocin 1, P23.
What is the protein family that this protein belongs to?
Belongs to the paralithocin family.
Protein: SYS_SHIFL
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FXL14_BOVIN
Sequence: METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKVR
What is the function of this protein?
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes.  The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity).
What are the official names of this protein?
F-box/LRR-repeat protein 14, F-box and leucine-rich repeat protein 14.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_SHEPW
Sequence: MIGRIRGLLVEKQAPEVLIDVSGVGYEIQMPLTSFYELPEIGLEAVVFTHFVVREDAQLLYGFISKQERALFRLLIKTNGVGPKLALTILSGMTAGEFVACVERDDIATLVKLPGVGKKTAERLLVEMRDKLKSLMEASVGSEREFMLQSNYTAPVVANTAEEDAIAALLSLGYKPAQASKAVSAVYVDGIDSESLIKSALKSML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: E4PD_ALIF1
Sequence: MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKVTHDQEYPYSDVPDSSQDKVRILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAGAKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCTTNCIIPVIKAIDDAFGIDSGTITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALAMSK
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_RHOPS
Sequence: MTVIVPIHGPAPAPAPVPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGLFWKLALNGIILNTRPARKAKDYQKIWNHEKNESPLKTITRAQAEKLAASLTDRSHLVVDWAMRYGNPSLRSRIEALVARGCSRLLVVPLYPQYSAATSATVCDQAFRVLRELRAQPTLRVTPPYYRDDAYIDALANSINAHLATLSFEPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALRERMGLDEKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFASDCLETLEEIAQENAEIFMHNGGEEFSAIPCLNDSDDGIAVIRQLVMRELQGWL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_TERTT
Sequence: MALSAQEKDAIVKEHQTSETDTGSPEVQIALLTANINKLQGHFADHKQDHHSRRGLIRMVNQRRKLLDYLKGKDVNRYAALIQKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TRPB_CAMAC
Sequence: MAVYTNPACRTNTSAFPGPYRPYSNPSRFSFNLDKFRPRTSAIKVPSICCTIAREMEKERSEREPDVLQRPDSFGRFGKFGGKYVPETLMYALTELESAFRSLSGDQVFQKELDGILKDYVGRESPLYFAERLTLHYKRPNGEGPEIYLKREDLNHTGAHKINNAVAQALLAKRLGKKRIIAETGAGQHGVATATVCARFGLQCVIYMGAQDMERQALNVFRMRLLGAEVRAVHSGTATLKDATSEAIRDWVTNVESTHYILGSVAGPHPYPMMVREFHAVIGKETRKQALEKWGGKPDVLVACVGGGSNAMGLFHEFVDDKDVRMIGVEAAGFGLDSGKHAATLTKGEVGVLHGAMSYLLQDDDGQIIEPHSISAGLDYPGVGPEHSFLKDIGRAEYYCCTDEEALEAFKRLSRLEGIIPALETSHALAFLEKLCPTLPNGTKVVLNCSGRGDKDVHTAIKHLQV
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPA_YERPY
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLADVMQGEMIALPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGEPIDGKGSIENDGFSAVEAIAPGVIERQSVDEPVQTGYKSVDAMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCVYVAIGQKASTVANVVRKLEEHDALANTIVVVATASESAALQYLAPYSGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLGDVELAKVGSFEAALLAFADREHAELLQQINQTGAYNDEIEAKLKGILDTFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COX41_MANSP
Sequence: SVVKSEDFTLPAYVDRRDYPLPDVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRRSNEWKTVVGTAMFFIGITALVIMWEKLY
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase IV family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PEMI_ECOLX
Sequence: MHTTRLKRVGGSVMLTVPPALLNALSLGTDNEVGMVIDNGRLIVEPYRRPQYSLAELLAQCDPNAEISAEEREWLDAPATGQEEI
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to its cognate PemK endoribonuclease toxin and neutralizes its activity.  Responsible for the stable maintenance of the plasmid during cell division.  Both PemI and PemK proteins bind to the promoter region of the pem operon to autoregulate their synthesis.
What are the official names of this protein?
Antitoxin PemI.
What is the protein family that this protein belongs to?
Belongs to the PemI family.
Protein: YACG_GEOSM
Sequence: MNAITTIKCPQCRKETTLAGNPYRPFCSQRCKMIDLGTWADEGYRIPGEKAPESGGEEPGDE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: CRN1_PHYIN
Sequence: MVTLYCVVVGVAGSAFPVDIDENKSVGHLKDAIKEKNASTITCDAKNLQLFLAKKKKGAGVRLTENDVKDGVSDTSDLKLLGVAGAPLSLVGLSEKDVKFVPTLEDVESMNTPVHVLVVVPEQDGTISKEMSAATSPLTVEQVEMSMNKVLRERDEKASAYSFSDLNTAMEERIVKKMRLTENIPDVKEPVDTSIAGYSWIPKIVESEESQRAGYMEYLQQHLKTLIDRGDFLLDDIAGDKSVLNIVDPRLPFAMKGTADVLLINRTAKNPLIKLAGVSLVIELKKKVEPGHVPQAIGQLVSCSMKAPLNCYPLSLLTDLNDHWHFSWFSDKHVLTQVTLKYPKNAFRFIEAAVLGRTDSAPPPPSFMPGSFKTIKVDDFLPQPVDARAEEMMERYELMADVVEPEFLMARRMDYARQLVQSMPMYSYMYT
What is the function of this protein?
Secreted effector that elicits necrosis in host plants, a characteristic of plant innate immunity.
What are the official names of this protein?
Crinkler effector protein 1.
What is the protein family that this protein belongs to?
Belongs to the Crinkler effector family.
What are the subcellular locations of this protein?
Secreted. Host cell.
Protein: RL22_MYCA9
Sequence: MTTTTEFPSATAKARFVRVSPTKARRVIDLVRGKSVNDAIDILRWAPQAASEPVAKVIASAAANAQNNDGLDPSTLVVSEIFADEGPTAKRIRPRAQGRAFRIRKRTSHITVVVESRPKQEKGGKAGASKASSRAARAQGSKAAAAKKTESKGGTS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MNARL_DANRE
Sequence: MFEDKELEKHITPQTLKPKIKQNPLYSHINIIQTEENKSKPSWTIQDYDRHTSHGQLADYMKEDPRDLSFWLEDLYTPGYDSLLKKKAAEMKRNKICKTFAFITLFVCAVVIIITVPIVVKQSRD
What is the function of this protein?
Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (PubMed:36317962).  May play a role in angiogenesis (By similarity).
What are the official names of this protein?
Major intrinsically disordered NOTCH2-binding receptor 1-like, Major intrinsically disordered NOTCH2-associated receptor 2.
What is the protein family that this protein belongs to?
Belongs to the MINAR family.
Protein: LDHD_DICDI
Sequence: MKITLFSSKPYWVKWFNELNKFSYEINYVTSACDIKSVNEAKGSEAVCCFVNDDLSKEVIETLHSNGTKVILMRCAGFNKVDLDTANKLGIPVLRVPAYSPNAVSEYALSLIMALNRKTHKAHDRVRDANFEINGMEGFNMVSKVYGIVGTGNIGEQLCRVLKLGFGAKVIAYDIIENKAVTDIGIEYVKTLDEIWKQCDVISLHTPLNSQTKYMVNSESIEKMRDGVMIINVSRGALVNASDAIVGLKSGKISSLGMDVYENETDYFYQDHNGSIIKDDNLSLLISYPNVMITSHQAWYTKEAISCICGTSLQNFVDFRSNQIKKSNLVNNPISSQPTQ
What are the official names of this protein?
Putative D-lactate dehydrogenase, D-LDH.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: GCSH_METEP
Sequence: MLRFTDEHEWLRLDGDVATVGITAHAAEQLGDLVFVELPKVGAKLTKGEAAAVVESVKAASDVYAPLSGEVTEVNEAAVADPASVGTDPQGDGWLYRLKLDDASAMDGLMDEAAYAAFAK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RLMD_XYLFT
Sequence: MARQNRFDRTSFQTQIIDLSHDGRGVARPHGEGGKVTFVTGALPGEVVIVEPVARNRHFDEARVVEVLQASPQRVIPRCSHFGVCSGCVLQHLAEDAQVVSKQRVLLESLERIGCVSPERVLPALAAESWGYRRKGRFSVRWVEKKGRTLVGFREHDPRFVADVSVCHTVVPQVGEKIALLATLLDSLDGRCDVPQIEFIAGDAVVALTVRHLQPLSEADRLALIEFGKEHGIAIFLQSGGVESVRLLWPDEVLLAFRLKPWDVEFVFRPLDFIQINGGLNEKMIAHALDLLGAGFGERVLDLFCGLGNFTLPLARTVGEVVGVEGDIGLVERARENARRNGLGNAEFFVADLTRDQRDAPWMRQGFDKLLLDPPRSGAIEVLKQLPLKMFERIVYVSCHPGSLARDADFLVNEQGFVLRAVGAMDMFPHTAHVESIAVFDRC
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RIMP_PARMW
Sequence: MPHPLLPELETLATSVAADQGFELCGIQLLTHLAPMTLEVHIRRSNGVDVNMDDCAGFSGTLGEALESAQLLTEAYVLEISSPGIGETLSSDRDFQTFRGFPVEVVHRDRDDTEQRLEGLLLERDEDTLQINIRGRIKRLPRDHVLSVRLTSPGS
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.