PharMolix/UniProtQA huggingface dataset:
Protein: CSN8_PONAB
Sequence: MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIVADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 8, Signalosome subunit 8.
What is the protein family that this protein belongs to?
Belongs to the CSN8 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LEUC_SALPA
Sequence: MAKTLYEKLFDAHVVFEAPNETPLLYIDRHLVHEVTSPQAFDGLRAHHRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGSAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGCDFDEAVEYWKTLKTDDGATFDTVVTLRAEEIAPQVTWGTNPGQVISVTDIIPDPASFSDPVERASAEKALAYMGLQPGVPLTDVAIDKVFIGSCTNSRIEDLRAAAEVAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRSIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MENH_ECO5E
Sequence: MILHAQAKHGKPGLPWLVFLHGFSGDCLEWQEVGEAFADYSRLYVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILSFWLVGYSLGGRVAMMAACQGLAGLCGVVVEGGHPGLQNAEQRAERQRSDRQWAQRFRSEPLTAVFADWYQQPVFASLNDDQRRELVVLRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQILRF
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: TYB10_BOVIN
Sequence: MADKPDLGEINSFDKAKLKKTETQEKNTLPTKETIEQEKQAK
What is the function of this protein?
Plays an important role in the organization of the cytoskeleton.  Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
What are the official names of this protein?
Thymosin beta-10, Thymosin beta-9.
What is the protein family that this protein belongs to?
Belongs to the thymosin beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RS12_HAEIE
Sequence: MATINQLVRKPRVKKVVKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRIRLTNGFEVTSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGALDCAGVKDRKQGRSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CQ058_XENLA
Sequence: MIPALTVPLLFLCATSASPAAGRGVLVPPDPKSKLIPSTTKGTHAIAKPTPSQAALRHLMVPADNFGLEMLTDHQRTRATHPQRQGQDLALPDKTRAKTKVTLDNNTGPRKVNSLSNREALAGAQPEGRNFIPSFFGNSKVHQDRSQLSSYFQLHTKSSSLTASQNLQGRKYSRNNDYGSMDHESNRPGKMNPHREEEVVSNSTKPAWVINRQPSSVLFQRPAFRKGFDNKEMCIAECHRDKDEREAYCNSDFAVNGIVQDMESVGKESRLLTLLVSSDGLYKMNRLYISPDGFFFKVKILVTDTLNCHKPCLDFKPGVRYIIMGQIYHKRIIFPQAMQHLLGGRLRAGDGFIKSSSYVQRFNRKRGRKVLAAAHSKCR
What are the official names of this protein?
UPF0450 protein C17orf58 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0450 family.
Protein: GRM6_MOUSE
Sequence: MGRLRVLLLWLAWWLSQAGIAHGAGSVRLAGGLTLGGLFPVHARGAAGRACGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGEEASVRCPGGVPPLRAAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIIATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAVCASRRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPKSENSEDAK
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity (By similarity).  Signaling stimulates TRPM1 channel activity and Ca(2+) uptake.  Required for normal vision.
What are the official names of this protein?
Metabotropic glutamate receptor 6, mGluR6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi- pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane (By similarity). Detected at dendritic tips of bipolar cells.
Protein: PURP_IGNH4
Sequence: MRVTDVLKEYDLSKLTVATVASHSALQIVHGAKKEGLRTLLIVKKDRYEFYSSFSHLVDSFIIVESWKEVLNEDVVNELLASNAVLVPHGSFVEYVGAQGLLDYPVPIFGSRKILLWESDQKKKMELLRRAGIKVPREYRSPDEVDGLVIVKLGGAKGGKGYFLAKTPEEVRRGLEALGNPSNYIIQEYVIGVPAYYHFFYSPIYNRLEITGMDIRYESNVDGLRRLPPELASGIRPSFTVVGNIPVVLRESLLIDVYKYGKSFVRTTEELLGEELVGPFCLESIITEEGEVVVFEFSGRIVAGTNLYVNGSPYSYLYWDEPMSAGRRVAREIRKARDSGRLEEVLR
What is the function of this protein?
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
What are the official names of this protein?
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MDTJ_SALPK
Sequence: MFYWILLALAIATEITGTLSMKWASVGNGNAGFILMLVMITLSYIFLSFAVKKIALGVAYALWEGIGILFITIFSVLLFDEALSTMKIAGLLTLVAGIVLIKSGTRKPGKPVKGAARATI
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS1_METM5
Sequence: MILLALPNKGRISKPVNEILEKAGLKISVHGRSLFAQTVDPEIKVMFARAKDIPEFVRDGVADVGVTGYDLMLERDTEEELEMLLDFKFGNARLVIAAPENSTVNSIEDVKDGMKIATEFPGLTKRYLEKKGLNLEIIELSGATEIAPFIGVSDLICDLTSTGTTLQLNRLKEVENVVSSTTRLVANKKSMDDPEKSAKINQVLSGIKSVLYAQSKRLIMMNAPKDKVSEITSIIPGMGGPTVSEILSNDKMLAINAVIDENKVFETVTNLERLGARDILVVPIERIL
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGB_STAA3
Sequence: MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL21B_SCHPO
Sequence: MPHSYGIRARTRYTFQRGFREHGQIRLSTYLKTYKVGDIVDIKVNGAVQKGMPHKYYHGKTGVVYNVTQSSVGVLIYKVVGNRYMEKRVNVRIEHVKHSKCRQDFLDRVKANEAKRKEAKAQGKTVQLRRQPAPPATAHFVSTENNEPVTLHPVAYDTTI
What are the official names of this protein?
60S ribosomal protein L21-B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: RNC_STRP6
Sequence: MKQLEELLSTSFDIQFNDLTLLETAFTHTSYANEHRLLNVSHNERLEFLGDAVLQLIISEYLFAKYPKKTEGDMSKLRSMIVREESLAGFSRFCSFDAYIKLGKGEEKSGGRRRDTILGDLFEAFLGALLLDKGIDAVRRFLKQVMIPQVEKGNFERVKDYKTCLQEFLQTKGDVVIDYQVISEKGPAHAKQFEVSIVVNGAVLSKGLGKSKKLAEQDAAKNALAQLSEV
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APHA_SALTY
Sequence: MKKITLALSAVCLLFTLNHSANALVSSPSTLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEVARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY
What is the function of this protein?
Dephosphorylates several organic phosphate monoesters such as 3'-UMP, 5'-UMP and pNPP (PubMed:6256351).  Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds such as the 2'-, 3-, or 5'-hydroxyls of nucleosides and nucleotides (PubMed:3049613).  Also displays significant phosphomutase activity since it is able to catalyze the transfer of the phosphate group of 3'-AMP from the 3'-position both to the 2'- and 5'-positions.  One of the physiological functions of the phosphohydrolytic activity of the enzyme is believed to be the scavenging of organic phosphate esters that otherwise cannot pass the cytoplasmic membrane (PubMed:6256351).
What are the official names of this protein?
Class B acid phosphatase, CBAP, Non-specific acid phosphatase II.
What is the protein family that this protein belongs to?
Belongs to the class B bacterial acid phosphatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL13_MYCTA
Sequence: MPTYAPKAGDTTRSWYVIDATDVVLGRLAVAAANLLRGKHKPTFAPNVDGGDFVIVINADKVAISGDKLQHKMVYRHSGYPGGLHKRTIGELMQRHPDRVVEKAILGMLPKNRLSRQIQRKLRVYAGPEHPHSAQQPVPYELKQVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ZNF2_PONAB
Sequence: MAAVSPTTRCQESVTFEDVAVVFTDEEWSHLVPTQRDLYKEVMLENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASNEKSEGSLRECLGRQSPLCPKFEVHTPDGRMGTEKQSSSGETHKKSLSQDKGLRRGSALPREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCHECGKAFSHRSSLSRHLMSHTGESPYGCSVCAKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECSVCGKVFSSKSSVIQHQRRYAKQGID
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 2.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNH2_YERP3
Sequence: MSETFIYPQANLIAGVDEVGRGPLVGAVVTAAVILDPNRPIVGLADSKKLSEKRRLSLYDEITEKALSWSLGRAEPEEIDQLNILHATMLAMQRAVSGLHIVPDYVLIDGNRCPKLQMPSLAVVKGDSRVAEISAASILAKVTRDREMTELDLLFPEYGFAQHKGYPTAFHLEKLAALGATVHHRRSFGPVKRVLGLV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLG1_DANRE
Sequence: MPVRQKDAQRALQLLEEYQTKLSQTGDPHLRLSIERVINIFKSTLFQALVDIQEYYEVSLQDTEDKPIEDSSLKSRESFPPVNEWNLSVPPSTTGPTEPVPINLPQTEEKYRYQDEDTTSPPEHSSPHIPGDARPPELVQVSEKNISQIENVHGYVSHSHISPMKQADVIPPPSAPIIPVIPISPVPAETTAIIPAPASQASPAPVVVNTESLDSSPYVNGTEADYEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKIIPGGAAAQDGRLRVNDCILRVNDVDVRDVTHSNAVEALKEAGCIVRLYVRRRKPLSEKIMDVKLVKGPKGLGFSIAGGVGNQHIPGDNSIYITKIIEGGAAHKDGRLQIGDKLLAVNAVCLEEVTHEDAVAALKNTPDVVYLKVAKPTSVFMNDSYAPPDVTSSYSQHMENHISTQSYLSQPLTPATPSRYSPVSKGMLGDDEITREPRKIVLHRGTTGLGFNIVGGEDGEGIFISFILAGGPADLCGELRKGDRIVSVNGVDLRSATHEQAAAALKNAGQTVTIIAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRTLYVRALFDYDITKTVKFNSKSRDKASLNDKRRKTLFSRKFLFSKNKDSGEQDTSDVDQHVTSNASDSESSFRGQEDYVLSYETVTQQEVSYSRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVNSREQMEKDIQDHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQLAQLYPIAVFIKPKSVENILEMNKRLMEEQGRKTYDRAMKLEQEFLEHFTAIVQGDTLEEIYNQVKQIIEEQSGPFIWVPVKEKL
What is the function of this protein?
Essential multidomain scaffolding protein required for normal development.  Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells.  May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity).  May play a role in synapse assembly and function.
What are the official names of this protein?
Disks large homolog 1, Synapse-associated protein 97A, SAP-97A, SAP97A.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Endoplasmic reticulum membrane. Cell junction. Apical cell membrane.
Protein: RS6_SYMTH
Sequence: MRKYEMMVIARPDLDEAGLQALSDKIAELITSNGGTVESQDAWKKQRLAYEIKHLREGFYSVFNFTGEPRTANELNRVLKITDEVVRFLIVRPAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: COQ7_XANOR
Sequence: MTQTSPSRLHSPLDRLLVEAQRALDTVFGNPPAERPNPAADTPDIALDPEQRRHAAGLMRINHVGEVCAQGLYFGQAAVARDAHTQHHLLEAAQEETDHLAWCADRLHELDSRPSLLNPLWYAGSYALGALAGLRGDDWSLGFVVETERQVEAHLDEHLETLPDIDQRSRAILRVMKIDEARHADQAEQAGARQLPAPIPGAMALASKLMKTVAYRL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TYSY_CERS1
Sequence: MAHPEQQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSDGQVPILTTKRVYWKTAVKEMLWFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRILEDEAFAARWGELGPVYGRQWRRWLGPDGREHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQYHVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLNHLDQAREQTGRAPRDWPRMRLLRQADGIDDYRIEDFAVEGYDPHPAIAAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_SACEN
Sequence: MLDVNFFDELRIGLATADDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAASVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVNTEMRHNEMSTLEAEIGVERKQIADQRDADLEARAQKLEADLAELEQEGAKSDVRRKVKEGGEREMRQLRDRAQRELDKLDEIWETFTKLEPRQLIADELLYRELYDRFGEYFTGGMGAESIQALLQDFDINAEADQLRETIRSGKGQKKLRALKRLKVVAAFQATGNNPSGMVLNCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKEMAVELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYHLTRQLDGAKGEGQSFSSVGEAIMAFDRGGLDLQAKVKIRVRDLVPNAEQRPEDWEPGQPWLAETTLGRVWFNELLPEDYPFVNDLLPKKRQAAIVNDLAERYPMVTVAQTLDKLKDAGFHWATRSGVTVSISDVVVPPNKTEILDGYEAKADQVEKRYRRGALSYQERNAELVKVWTAAKDEVAEAMEANFPEDNSISMIVKSGAAGNMTQVVQLAGMRGLVSNPKGEYIPRPIKANFREGLSVLEYFISNHGARKGLADTALRTADSGYLTRRLVDVSQDVIVRETDCGTERGIRMPIAEKLPDGKLLRDAHVETSVYARTTAEDVTDSDGNVVLARGSDLGDPAIEKLLAAGVTKVKVRSVLTCESGVGVCAVCYGRSMATGKLVDVGEAVGIVAAQSIGEPGTQLTMRTFHQGGVAGDDITTGLPRVQELFEARVPKGKAPIADAPGRIRMEDNDRYWKITIIPDDGSEEIVYDKLSKRQRLAAISVDGTERQITDGDHVDVGQQLLEGAVDPHEVLRVMGPREAQLHLVREVQEVYRSQGVGIHDKHVEVIVRQMLRRVIIIDSGATEFLPGSPVERSQFEGENRRVVAEGGDPASGRPVLMGITKASLATESWLSAASFQETTRILTNAAIEGASDKLVGLKENVIIGKLIPAGTGINRYRNIQVQPTEEARAAAYAIPSYDDGYYTPDVFGTGTGAAVPLDDYDFGRDYR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PIMT_BURMA
Sequence: MSGERAKRFPLALEDLKREPRKPEGRVAERQAAGDAARQRLTAAAAVPAAASPIVPERRAPHGGVFAAKPARAKQHAPAAPGAAKRAPQGGAKQGDRSAAPNVALSGALALTSERVRERMVERLRANGVADPRVLAAMSAVPRHMFVDPGLAAQAYEDAALPIGHQQTISKPSVVARMIELAAAGRALERVLEIGTGCGYQAAVLSRVARDVYSIERVRPLYERAKLNLRPLRVPNIRLHYGDGRVGLPAAAPFDAIVIAAAGLDVPRALLEQLAIGGRLVAPVGEQAGEQVLTLVERVAPAQWRESRLDRVFFVPLKSGVI
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRED_ASPOR
Sequence: MALSFFSGGGSASHAKYFDIRLDEDYIVFRGGEQEAASAHLSGKLLLCLSEPLSIKHIRLHLTGISRVCWHLPSSSAGGGRKSWRERVIYEKTWRFRDPGKGKTEILPAGNYEYPFNLVLEGNMPESIEGLSDTYITYRFKAEIGRKYAKDIIVRKPLRIIRTLEPSALELAHAMSVENIWPNKIEYSISTPTKAVIFGTSIRVDFKLIPLLKGLTIGQIVSQLIESHDLTLNPEDPDSIRNTYKNTRTILNDEFELDHDNALEIIDEAAEGYQFSRYLDLPKTLTRCLQDTDTKGIKVRHKLKFRVQLMNPDGHISELRATLPVSIFISPNLAIDENNNLVDQTPQSAQRAINDIAQQAPPLYGEHQFDQLYSELDPNGYRTPGPGSGPGTPFGTLSRNLSAENLASMNALTNTDISASALHSRLSNLSNLNITRPHQPSPTDHESQNDSEHRRLGVPADYFGPSSGSNSHSPSSPVLSRRPSDEVDHEHVPSGMATPFHPQYAEVETLSRVPSYSTAVRTTKTFPFRHLSSHLSKPISEMLGADLANSSLPWIFFIIGRALVTLTPLVTMMKTEDCDSFKLGLESRIRTEAASPA
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability (By similarity).
What are the official names of this protein?
Probable HECT-type ubiquitin ligase-interacting protein creD, Carbon catabolite repressor D.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: SYR_PYRAR
Sequence: MDPLKLPKQEFADALGKISSRLGLAEVPEIEKTRRYGYFSARFHKYKIDPTRLRDAVEELSNAGFQYISGLSAEGLYVNADLNAKRLGELVFEAVAKMGKKYGFTEECQLGSFLVEHTSANPIHPLHIGHGRNAILGDSLARLLRFCDNRVEVHFYVDDCGVQVMYATIGYNAVRDEAREWIERAKPDLVVGHIYSATNAVAEIGRLKKEAERAQDDEHKRSLIGEIDEWVAVLKRLMESEGDLVAKVVERLGQRDVAGEAVELNRRYEAGDPEAKRVVREVVDLVLRGQRETLARLGIEIDRWDYESELAVWSGEASRIVEELQRRWPQYVEYKGGAVVFRADKFVDDFKLWDVLDLPKFIPPVTLTRSDGTTLYVTRDVAYALWQARQGFDKVVRVISTEQTHEQAHVRIILYALGFEDVAKKIVHYAYEMVNLPGMKMSARRGRYISLDEILDEAAERSASLVKEKSPEIAGVIAEKVGVGSVRYAFLSTSPRKPIEFRWEVVLNLRQNSGTFLQYTYVRAYSILEKAPDVERASVPEQMLEEEKELLVKIAEWPSVVREAVRALRPDYVAEYLDGLALLFNSYYEKAPVLKAVEGVRKFRIALVNAVKTVLEAGFYILGIPTLTKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.