PharMolix/UniProtQA huggingface dataset:
Protein: CNR2_RAT
Sequence: MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
What is the function of this protein?
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase.  May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity).
What are the official names of this protein?
Cannabinoid receptor 2, CB-2, CB2, rCB2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons.
Protein: FADB_PSYWF
Sequence: MIYQGNRITVSLLDDGIANMQFNAEGESVNKFDAETNKQFDEAVSALEKADNVKGLIVTSSKGVFIAGADITEFVSHFNKEAAEIEKWIVDINGVFNRFEDLPFPKVAAINGAALGGGCEMTLVCEYRVMGDKAQIGLPETQLGIFPGFGGSVRTPRVIGIDNAVELIATGKAQKPAEALKLGLVDAVVAQDDLQEAAVDLVKKCIAGDLDWQAKREEKLQPVKLNQLEQTMAFSTAKAAIFAKANPKQYPAPAIAIETIEKHVNLGRDEAIKVEAAGFAKAAKTPQAESLVGLFLNDQTVKKLAKQHTKNAHDINEAAVLGAGIMGGGIAYQAASKGLPIIMKDIKSEQLDLGMGEASKLLGKMVERKKMTPAQMGETLSRIRPTLNYGDFGETDIVIEAVVENPKVKHAVLKEVEGLVKDNAILASNTSTISITYLATVLERPENFVGMHFFNPVHRMPLVEVIRGEKSSEEAIATTVALAQRMGKVPVVVNDCPGFLVNRVLFPYFGAFDLLLKQGADFVHVDKVMEKFGWPMGPAYLIDVVGLDTGVHGAEVMAEGFPDRMKPDYKGAIKHLFENNRLGQKNGVGFYKYEKDSRGKPKKTADDATYALLKDTTDTDNQQFDDQTIIDRMMLAFCNETVRCLEDNIVATPSEADMAMIMGVGFPAFRGGPCRYIDQVGLDNYLALCEKYAHLGKAYEAPQKIRDMAAAGETFYPKA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: COXX_ARTS2
Sequence: MSTTDTPLNASRLPGKIGIARKAKAYLALTKPRVIELLLVSTLPTMIYAERGFPSFGLILATLVGGAFAAGSAGAFNCYIDRDIDKLMHRTENRPLVTGEVTPREALVFSWLLGAAAIAILWFGANPLSAWLGLGAIVFYVVIYTMILKRRTAQNIVWGGAAGCFPVLIAWAAVTDTVEWPAIVLFMVIFLWTPPHYWPLSMRYGEDYRNANVPMLGAIAGAKVVSVQVVLYAWAMVACSLLLIPAGGAGWVYTVTAVVAGAWFLYESHALYNRAQGGDVSNKGAMKVFHGSISYLTLLFIALAVDPFVGSAIMG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y220_RICBR
Sequence: MSKAVISEKAEPRELKALYIVGPEIEPDPEILKLYDRKDCLVVGDGIDDADIYAIYLELKKHNVQIGPNTRIDIAAHGKRVDKKHYLRLSTEEVTETKKFLQQLQGSSPIDPIYVHLWSCYGGTANKDIAFLNPGSIIVTHVKSQYSSFGPADNFAHLHSITRYINEKNLTPHLQYLYDQLENYQATTFNQKESDGRIVKFKTTRTPEHDSMANIISNILEQKQSEELLKEFQNYLNKEAENFSKLFGEYLASEDKEKFQHYTSNISDKDLKNYVTGLLLNIANLSNKNNIKDKEKILTILNKIVNILGTSLLAVTVRNNNVELTKALLNKGADQHAKYTKIDMSLLYIACLNKSVDIAKLLLEYNVDPNYPTTDNDTPLLQACEKKSPELVKALLAKNADPNKVSDRGLSPLIVSCINPSEESREIALNLLANKNIKVNILGPNDFTPLILACYNNSERVVQALLDKEADVNAKDKDGFTPLFAAYRNHSTKITELLLEKGANPDVINPKTKSSILYNACNEGDLNIIKLLLKHKANPNLTTFDGTTPLMAACEKGDLEIAALLLKNGADINKSNNNGDNALFLACKNGNLELVKMLVENGVDLKKGSRGMIASSIAKKNGYEKVGAFLKAEIKSQRTLNTNQSNNPLPPKPPRLIKNTTTQNEENKKTWIKSEANLTLSQPHYNFLQSNSEAKSRALREINPLIEAAIKEVDKVNTVNVAVREEVQNILSKELLRIPINNLVDNKKGIINQITKELKLNNSQDNNNREYKISQQSLKEIGNKIFAAYGHKIQPQLTNTTTHRWQNYIKTTNNTNANKSNYLGKR
What are the official names of this protein?
Putative ankyrin repeat protein RBE_0220.
Protein: SYK_THET8
Sequence: MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRLVALRRMGKVTFAHLLDETGRIQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVTVKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVNPEVREVFRRRSEIVRYIRRFFEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFEIGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRVLNFKPPFRRISFVEALKEKAGLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYVEPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGGMELAPCYSELNDPLDQRERFLEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPLLKPKKEAVEEGV
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDK_SHISS
Sequence: MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKTVVLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQTSHLMD
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: CPGS_METKA
Sequence: MTAVKRILALVDGEHYIPVTREALETVEELDLGELVGAVFIGGTEKISEPEAVKRELGVRVWLSESEDEIPVDMIVKVIEEEDVDVVLDLSDEPVVSPDNRFEIASAVLSAGAEYWCPDLRLKPVEFHDVLEKPSLRIIGTGKRVGKTAVSAYTCRVLNARGYNPCVVVMGRGGPREPEIVRGDEIELTPEYLLKEAEKGKHAASDHWEDALLSRIPTVGCRRCAGGLAGRTFTTNIVRGAKIANELPADFVVVEGSGAAVPPIKTDAGIVIVGANQPLEHIGGYLGPYRIRMCDLAIITMCEEPMADDAKIRKVERTVREAGDGIEVVLSVFRPKPTEDVEGKRAMFVTTAPEEVVSRLVEHLEEEYGCEIVGTSPHLSNRPKLRKDLEKYIDDADILLTELKAAAVDVATREALKAGLGVVYVDNVPIAVGGDYDHVGDAVENVAELAIDRFEG
What is the function of this protein?
Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
What are the official names of this protein?
Cyclic 2,3-diphosphoglycerate synthetase, cDPGS.
What is the protein family that this protein belongs to?
Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG4A_MOUSE
Sequence: MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTASNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3.  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.  Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity.  Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy.
What are the official names of this protein?
Cysteine protease ATG4A, AUT-like 2 cysteine endopeptidase, Autophagy-related cysteine endopeptidase 2, Autophagin-2, Autophagy-related protein 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAND1_CAUVC
Sequence: MPKIIAAKTIVTCPGRNFVTLKIMTDEGVYGLGDATLNGRELAVEAYLTQHVIPCLIGRDAHQIEDIWQYLYRGCYWRRGPVTMAAIAAVDTALWDIKGKIAGLPVYQLLGGACRVGVMVYGHANGETIDETLDNAAVYAQQGYKAIRLQTGVPGMSGTYGVSKDKFFYEPADSDLPKETIWSTERYLRSTPALFEAARERLGDDLHLLHDVHHRLTPIEAARLGKDLEPYRLFWMEDATPAENQASFRLIRQHTTTPLAVGEIFNSIWDCKQLIEEQLIDYIRATVVHAGGITHLKKLASFADLHHVRTGCHGATDLSPVCMGAALHFDLSIPNFGVQEYMRHTPETDAVFPHAYTFKDGMLHPGDAPGLGVDIDEDLAAKYPYQRAYLPIARRLDGSMHDW
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-mannonate dehydratase CC2812, ManD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: ROMO1_HUMAN
Sequence: MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC
What is the function of this protein?
Has antibacterial activity against a variety of bacteria including S. aureus, P. aeruginosa and M. tuberculosis.  Acts by inducing bacterial membrane breakage.
What are the official names of this protein?
Reactive oxygen species modulator 1, ROS modulator 1, Epididymis tissue protein Li 175, Glyrichin, Mitochondrial targeting GxxxG motif protein, MTGM, Protein MGR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the MGR2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: TBX3_CHICK
Sequence: MNIPMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALALPPNGAAALSLPGALAKPIMDQLVGAAETAIPFSSLGQQAAAHLRPLKTLEPEEEVEDDPKVHLEAKELWEQFHKRGTEMVITKSGRRMFPPFKVRCTGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVYDERQKKENPTSDESSNEQTAFKCFAQSSCPAVPAVGTSSFKDLCPGEVDRDXDSXDDXXLEXSEWGKISTTTXTHPWXQPAXGRQRVTTXGTKGAAVPKATSSPXTR
What is the function of this protein?
Transcriptional repressor involved in developmental processes.  Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes.  Probably plays a role in limb pattern formation.
What are the official names of this protein?
T-box transcription factor TBX3, T-box protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: EAF3_CANGA
Sequence: MFEVGGKCLAYHGPLLYEAKILRRWNPKLEKVEYSVPLKSGEEDGLPESMNREEFYYYIHYQGWKSSWDEWVSVDRIMELTEANIELKKQLVMEAKKASLAQQQKTKNGGSAKRGGGGAHSESNHGGRRSGSGDRRDSNAEERGIVPSEGPFRTSSVMSYNFSRNKLRIHIPMILESMLVDDWEIVTKEKKISNLPNPFPVETILDRFYKDVATRTTSPVELSLVEEYVYGLKQYFNEAIGNLLLYKLERLQYEQVFYPTPEQQQAMTPVERSLSGRRPGQLYGVLHLLRLISILPEMLSNCVGMDTQAINVILRHTEKLLLWLVDRIEDLLPHKVHKSYYTNTSSQYEGVALGL
What is the function of this protein?
Involved in deacetylation of histones, chromatin assembly and chromosome segregation.  May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains.  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein EAF3.
What is the protein family that this protein belongs to?
Belongs to the MRG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYR_STRT2
Sequence: MNTKELIAAEIAKVVPELEQENIQNLLEIPKNADMGDLAFPAFSLAKVLRKAPQMIAADIAEKIDASNFEKVEAVGPYINIFLDKSKISADVLGQVIAQGSHYADQNIGNGRNIAFDMSSPNIAKPFSIGHLRSTVIADALANIVAKQGYKPVRINHLGDWGKQFGMLIVAYKKWGSEEAVKANPINELLQLYVRINAEAEEDPSVDEEAREWFRKLEAGDEEATALWQWFRDESLVEFNRLYDELGVSFDSYNGEAFYNDKMDEVVDILTKKGLLQESQGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKAIYVVGNEQSAHFKQLKAVLKEMGYNWSDDMTHVAFGLVTKNGKKLSTRKGNVILLEPTIAEAVNRAQAQIEAKNPNLPNKEAIAHAVGVGAIKFYDLKTDRMNGYDFDLDAMVSFEGETGPYVQYAHARIQSILRKADFTPSADATYSLNDVESWEIIKLLQDFPRIINRASDNFEPSIVAKFAISLAQAFNKYYAHTRILDESPERDSRLALCYATATVLKEALRLLGVEAPDEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_XANC8
Sequence: MTQPIARSIPLQVVSGDTAAPASLQTGVKQIGGDKINRSPVQFVDAPVLRKPSWIRVRIPSGNAVQNLKAKLRENRLVTVCEEASCPNIHECFSHGTATFMILGEVCTRRCSFCDVAHGRPKPPDASEPASLATTVADMGLKYVVVTSVDRDDLRDGGAQHFVDCISAIRASAPKTRIEILTPDFRGKGRMDRALEILATSPPDVFNHNIETVPDLYPNVRPGADYQWSLTLLQRFKAQHPTIATKSGIMLGLGETMEQVQVTLRDLRAHDVDMITIGQYLQPTPHHHPVMRYWTPEEYKALEEYGNALGFSHVASGPMVRSSYHADRQAAGAGVAA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2627_STAAM
Sequence: MKKLAVILTLVGGLYYAFKKYQERVNQAPNIEY
What are the official names of this protein?
Uncharacterized protein SAV2627.1.
Protein: Y2800_CROS8
Sequence: MFGGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein ESA_02800.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RENT1_SCHPO
Sequence: MSLGLQPNNDISSLVSSKNMTSENGLEHQFEELLVEKQYSEEHCAYCHIKNPNSILKCLHCNKWFCNVRGKSGASHIISHLVRARHKQVALHSHSSLSDTVLECYNCGTRNVFLLGFIPAKAKTVVVLLCRQPCARASIAKDMNWDLTQWQPIISDRQFLPWLITPPSEEEQKLAIPITSQQMVRLEELWRKDPNANLEDLDKPIEDDSLPSVELRYKDAHAYQAVLSPLIQAEADYDKRLKESQTQKDVVVRWDQAINKRYTAWFLLPKLESGEIRLAIGDEMKLTYEGELRAPWSSTGYVIKIPNNVSDEVGLELKRSDKVPIECTHNFSVDYVWKSTSFDRMQTALRLFATDGSRLSSFLYHKLLGHDIPPSFLKPKLPSDLSVPNLPKLNASQSEAVRAVLSKPLSLIQGPPGTGKTVTSASVVYHLATMQSRKRKSHSPVLVCAPSNVAVDQLAEKIHRTGLRVVRVAAKSREDIESSVSFLSLHEQIKNYKFNPELQRLLKLRSENNELSIQDEKKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKYKFRSVLIDEATQASEPECMIPLVLGAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFERLIILGNSPFRLVVQYRMHPCLSEFPSNTFYEGTLQNGVTTSERIARHVDFPWIQPDSPLMFYANFGQEELSASGTSFLNRTEASTCEKIVTTFLRSNVLPEQIGIVTPYDGQRSYIVQYMQNNGSMQKDLYKAVEVASVDAFQGREKDFIILSCVRSSEHQGIGFVNDPRRLNVALTRAKYGVIVLGNPKVLAKHALWYHFVLHCKEKGYLVEGTLNSLQKFSLTLTPPQKPQKFKRDLNVQRSLSPIQNAGSAMLPSFSNLPNLYSSSYLEEWNVFAQYKRRESNATDFEDFRSQVGDDESKFDEPTRF
What is the function of this protein?
RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity).  Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (By similarity).
What are the official names of this protein?
ATP-dependent helicase upf1, Nonsense-mediated mRNA decay protein upf1, Regulator of nonsense transcripts 1 homolog, Up-frameshift suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with polysomes.
Protein: HEMH_MOUSE
Sequence: MLSASANMAAALRAAGALLREPLVHGSSRACQPWRCQSGAAVAATTEKVHHAKTTKPQAQPERRKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: MNMC_CITK8
Sequence: MKQYAIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEERFPLHPRPLFVVAESGFGTGLNFLTLWQAFSQFRDAHPEATLQRLHFISFEKFPLTQADLALAHQHWPELAPWAQQLHAQWPLPLAGCHRLILDDGRVTLDLWFGDINELTGKLDESLNQKVDAWFLDGFAPAKNPDMWTQNLFSTMARLARPGGTLATFTSAGFVRRGLQEAGFTMQKRKGFGRKREMLCGVMAHALTFPSPTPWFTRSGSAKRDVAIIGGGIASALLSLALLRRGWQVTLYCSDEQPAQGASGNRQGALYPLLSKHDAAINLFFPSAFTFARRLYDALPVTFDHDWCGVTQLGWDEKSQHKIDQMLSLALPDALAVAVDPDQAQQETGVATHCRGITYPAGGWLCPAQLTAALLALAATQGLRRHYTHTLTALSRQATGWQLQFAEGKAVEHEVVVLANGHQINHVDQTRPLPVYSVAGQVSHIPTTPALSALRQVLCYDGYLTPQNPATHQHCIGASYHRGSEETAYREDDQQQNRQRLIDCFPDAAWAKEVDISEKAARCGVRCATRDHLPMVGNVPDYDATLAQYAALARQKDAAERAPVYPDLFMLGALGSRGLCSAPLCAEILAAQMSEEPIPMDADTLAALNPNRLWVRKLLKGKAVK
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_COXBR
Sequence: MATAREIPLNRTRNIGIMAHIDAGKTTTTERVLYYTGVSHKMGEVHEGSAVMDWMEQEQERGITITSAATTCYWLGMDQQYPKHRINIIDTPGHVDFTIEVERSLRVLDGAVAVFCSVGGVEPQSETVWRQANRYHVPRLGFVNKMDRAGANFLRVVNQVKDRLNANPIPIQLPIGAEEDFKGVIDLIREKAIYWNEADRGRTYELADIPEDMKAEVQKWREKMIEAAAESSEELMDKYLEAGDLSPEQIRQGLRQRTLANEIVPILCGSAFKNKGVQALLDAVIDYLPSPTDVPAIRGEEDDGSEGSRSASDDEPFAALAFKIASDPFVGTLTFFRVYSGILKSGDSVYNPIKGKKERIGRLLQMHSNSREEIKEVRAGDIAAAVGLKTVTTGDTICNQQNIITLEKMDFPEPVISVAIEPKTKADQEKMGVALGKLAQEDPSFRVHTDEESAQTIIEGMGELHLEIIVDRMRREFNVEANVGKPRVAYRETIRRSVEQQGKYIRQTGGRGQYGDVWLRIEPREPGAGFEFENAIVGGVVPREYIPAVEKGVREQMENGIRAGYPVVDVKVTIFEGSYHDVDSSEMAFKIAGSMAFKEGASKADPVLLEPIMKVEVVTPEEYMGDVVGDLNRRRGMIQGMDESPAGKIVDVEVPLAEMFGYATDLRSLSQGRATYTMEFLKYAEAPSNIAEAIIKQQS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_ECO8A
Sequence: MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVYAQTLYQIGALATIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALVLVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRSQPGALIENEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRSTFAEKEIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: ENOPH_XENLA
Sequence: MALFSVPTPVTTILLDIEGTTTPITFVKDVLFPYIKENIKKYLLEHWQEKECQEDITQLQKQAEKDSHIDGFVPIPSAISDNETENMIQAVVDNVYWQMSLDRKTTALKQLQGHMWRSAYITGQLKGEVYEDVVPSIRQWRELGFKLYIYSSGSVEAQKLLFGFSIEGNLLKLLDGHFDTTVGHKVESKSYRNIADSIRCSPENILFLTDVVKDMPLYLVTQESYPEAVIRGVCC
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase, MASA homolog.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y711_XANC8
Sequence: MEISSDNPDHGFQFPGTFELSAMGTAERGLETELPRLLAATGVELLEESISWKHSSSGKYVSVRIGFRADTREQFDSAHQALREHPEVKWTL
What are the official names of this protein?
UPF0250 protein XC_0711.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: MEP20_ASPFM
Sequence: MKVTILASAILALINGALALPANTPTLDVTLTQVDNTRIKATVKNTGNEKVTFVHLNFFQDAAPVKKVSLFRNGTEVEFTGIKRRLLTEGLSDDGLTTLAPGGTFEDEFDVASTGDLTEGGTVTIRTDGFVPITTDRKVSGYIPYQSNELEIEVDPAKAAAVPQAIKLLDRRTKVASCSGSRASALSTALRNAGSLANAAASAASSGSSTRFQEYFKTTSRRPENVGGRFRAVGREASSQSSGKTTYYCNDPYGYCDSNTLAYTLPSSNLIANCDIYYSYLPALTSSCHAQDQATTTLHEFTHAPAVYSPGTDDYAYGYRASTALSASQALLNADTYALFANGSPLLPLSNHSKCRNTMVWRTLL
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog mep20, Deuterolysin mep20.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FPG_VIBCH
Sequence: MPELPEVEVSRLGISPHLVGGTIQSLVLRTPKLRWPIPQELKQLEGQTILAIHRRAKYLIIETAVGSAIVHLGMSGSLRILDGDFPAAKHDHVDLVMTSGKRLRYNDPRRFGAWLWCAPDESHEVLGRLGPEPLTEAFNAEYMMDKARNKRIAVKAFIMDNAAVVGVGNIYANESLFTSRLHPLRPAHSLSLEEWQTLVANIKQVLQVAIKQGGTTLKDFTQSDGKPGYFAQELQVYGKAKQPCPHCGEPLCEQKIAQRNTFFCPQCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.