PharMolix/UniProtQA huggingface dataset:
Protein: CARB_BACCR
Sequence: MPKRLDINTILVIGSGPIVIGQAAEFDYSGTQACQSLKEEGYKVILVNSNPATIMTDTATADKVYIEPLTLEFVSRIIRKERPDAILPTLGGQTGLNMAVELAKSGVLDECGVEILGTKLSAIEQAEDRDLFRTLMQDLNEPTPPSEIIHNLDEAYGFVNEIGYPVIVRPAFTLGGTGGGICHNEEELIEIVTSGLKHSPVTQCLLEKSIAGCKEIEYEVMRDSNDNAIVVCNMENIDPVGVHTGDSIVVAPSQTLSDREYQMLRNTSLRIIRALGIEGGCNVQLALDPYSFQYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEIVNPVTQKTYACFEPALDYVVSKIPRWPFDKFESANRTLGTQMKATGEVMSIGRNLEESLLKAVRSLELGIYHLELDHLKELDKETMKKRIIKADDERLFIVAEAIRQGVTKEEINEWCEMDFFFLQKVENIVNMEREVKANVGNMEVLQTAKEMGFSDHYIAAAWNKTEREIYDMRKENNMMPVFKMVDTCAAEFESATPYYYSTYADENESIVTDRKSVVVLGSGPIRIGQGVEFDYATVHSVWAIKEAGYEAIIINNNPETVSTDFSISDKLYFEPLTIEDVMHIIDLEKPEGVIVQFGGQTAINLAAKLEEHGVKILGTSLEDLDRAEDRDKFEAALTKLGIPQPVGKTATTVEQAVAIAEEIGYPVLVRPSYVLGGRAMEIVYRQEELLHYMKNAVKVHADHPVLIDRYMVGKEIEVDAISDGENVFIPGIMEHIERAGVHSGDSIGVYPPQSLSEKLKEQIIEHTIALGKGLNIVGLLNIQFVVFKDQVYVIEVNPRASRTVPFLSKITGVPMANVATKVILGQDLVEQGYGTGYHPEEKEVYVKAPVFSFAKLRSVDTTLGPEMKSTGEVMGKDLTLEKALYKGLVASGINIPTHGSVIITVADKDKEEAMEIAKRFHEIGYNLLATAGTAQSLEEQNIPVQVVNKIDSEDYNLLDIIRQGKAQFVINTLTKGKQPARDGFRIRRESVENGVACLTSLDTTRAILRVLESMTFSAHSMKEITQTKRHEVVHA
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: ZNT5_CHICK
Sequence: MEEKYSSQALAGGGVLGPVDVPSARLTRYIVLLCFAKFLKAVGLFESYDLLKAVHLVQFIFIVKLGSAFFMVLFQKPFSSGKVVTKHQWIKIFKHAVVGCIISLLWFFGLTLCGPLRTLLLFEHSDVVVLSLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKIAEHPEGHHDSALTHVLYTVIAFLGVADHKGGVLLLVLALCCKVGFHMASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSLTTESKVESWSSLIMPFITVIFFVVILDFYVESICSVKMESSKCARYGSFLIFISALLFGNFWTHPITDQLRAMNKPAHHESTEHVLSGGVVVSAVFFILSANILSSPSRKGQKGTLIGYSPEGTPLYNFMGDAIQQSSQSLPRFIKESLKQILEEYDSRQIFYFLCLNLAFTFVELFYGVWTNSLGLISDGFHMLFDCSALVMGLFAALMTRWKATRIFSYGYGRVEILSGFINGLFLMVIAFFVFMESVARLVDPPDIDTNMLTPVSVGGLIVNLVGICAFSHAHSHGASRGGCHSHEHSHSYHGHSHSHGHGHSHNDHGHSHGHSHVSSGGGMNTNMRGVFLHVLADTLGSVGVIVSTTFIQQFGWLIADPLCSLFIATLIFLSVIPLLKDACQVLLLRIPPEQEKDLHAALEKIQKIDGVISYRDPHFWCHSASVVAGTIHVQVVSDVMEQRIVQQVTAILKDAGVNNLTVQVEKEAYFQHMSGLSTGFQDVLAMTQHLESMKYYKDGTYIM
What is the function of this protein?
Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15525635).  By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635).
What are the official names of this protein?
Proton-coupled zinc antiporter SLC30A5, Solute carrier family 30 member 5, Zinc transporter 5, ZnT-5.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Protein: MTNC_GLUOX
Sequence: MIRLVLLDIEGTTLPISFVRDVMFPYAAKALPALMQDHTNPIVVGARADIVMEHPGQDPLKVCQDWMKADVKAAPLKTLQGLTWRQGFEDGTLQADLYPDVPPALKAWSKGGLRLAVYSSGSIPSQKLLYGHTAQGDLTPLFEDFFDLSTGGKKDAASYEKITAAVGLPADEILFLSDIGAELDAAQRAGLSVCQLVREQDGTVPHPGVPQAPDLNAVSTQFGLPVA
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: BKT_CHLRE
Sequence: MGPGIQPTSARPCSRTKHSRFALLAAALTARRVKQFTKQFRSRRMAEDILKLWQRQYHLPREDSDKRTLRERVHLYRPPRSDLGGIAVAVTVIALWATLFVYGLWFVKLPWALKVGETATSWATIAAVFFSLEFLYTGLFITTHDAMHGTIALRNRRLNDFLGQLAISLYAWFDYSVLHRKHWEHHNHTGEPRVDPDFHRGNPNLAVWFAQFMVSYMTLSQFLKIAVWSNLLLLAGAPLANQLLFMTAAPILSAFRLFYYGTYVPHHPEKGHTGAMPWQVSRTSSASRLQSFLTCYHFDLHWEHHRWPYAPWWELPKCRQIARGAALAPGPLPVPAAAAATAATAAAAAAATGSPAPASRAGSASSASAAASGFGSGHSGSVAAQPLSSLPLLSEGVKGLVEGAMELVAGGSSSGGGGEGGKPGAGEHGLLQRQRQLAPVGVMA
What is the function of this protein?
Involved in the biosynthesis of ketocarotenoids which are powerful anti-oxidative molecules (PubMed:21398427, PubMed:22526507).  Catalyzes the conversion of zeaxanthin to astaxanthin via adonixanthin (PubMed:21398427, PubMed:22526507).  Catalyzes the conversion of beta-carotene to canthaxanthin via echinenone (PubMed:21398427, PubMed:22526507).
What are the official names of this protein?
Zeaxanthin 4-ketolase, Beta-carotene 4-ketolase, CrBKT.
Protein: DED1_ASPCL
Sequence: MADGLNMGNLSLNDSQHAPAGPGNTGRAAYIPPHLRGRAGGANVDAAAAAAPPPGPAAWNGPRQGAPPRGGNWANANASDFSPRAPSGPNGNNSWTPSEGQRRPFDPHAYGHPGHGGSYGGSQGASTRGSGDGQWRDGKHIPGPANARLERELFGVPNDPTKQSTGINFANYDDIPVEASGQDVPEPVNAFTNPPLDDHLISNIKLARYQTPTPVQKYSIPIVMNGRDLMACAQTGSGKTGGFLFPILSQAFQKGPSAVPAQASGQMSYGRQRKAYPTSLILAPTRELVSQIFDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLVNINYLVLDEADRMLDMGFEPQIRRIVEGEDMPSVNERQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDVDKRSVLLDILHTHGTSGLTLIFVETKRMADALSDFLINQRFPATAIHGDRTQRERERALEMFRSARCPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRELIDLLKEAHQEVPSFLESIAREGSGYGGRGGRGGRGRGGNANRDVRRMGGAMGGGAPSFGGGSYGGPGGSYGGGSYGGGAAAPSYGGGYGGASGGGGSYGGSYGNPSGPTGPSSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase ded1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_ALCBS
Sequence: MQQTCKRKIWMQISVALVTSLWMISAQAELLIKVTEGRVDAVPIAVVPFDGAKNAEEDVSAIVQADLHRSGQFKPLPPQDMLSRPRNEQEMIYRDFKVLGTEYVITGSMKRQETGGYEVGYALFDVARQKKLMSETYRPPASQLRDVAHAISDRIYEQLTGIPGAFSTKILYVTHNRHDANPYQLQYADADGHRVTTILRSNEPIMSPTWSPDGRKIAYVSFEDQGRPGIYIHNLATTEREKVSSFSGINGAPDWSPDGQHLALTLSRDGNPEIYMLNLSTKVLTRLTNNYGIDTEPRWLPDGEHLVFTSSRSGGPQIYKLNINDKSVRRVSFQGGYNARSDVTPDGRYLVYVHRRNGNYNVGVQDLQRGTFNIVTRTDMDESPSVAPNGSMVIYGTQHGGAGVLEAVSIDGRVKVELPSKEGEVREPAWSPFL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YCTF_SCHPO
Sequence: MSTSRLLLPTTNQQQNSSPVIKEVDLNQNTPIPVVWQKTKKPPFVSFPRHEPSETIVISSKPRLFSFAKKIKPEAEQRKRKRTTEI
What are the official names of this protein?
Uncharacterized protein C794.15.
Protein: PSBD_SYNY3
Sequence: MTIAVGRAPVERGWFDVLDDWLKRDRFVFIGWSGLLLFPCAFMALGGWLTGTTFVTSWYTHGLASSYLEGANFLTVAVSSPADAFGHSLLFLWGPEAQGNLTRWFQIGGLWPFVALHGAFGLIGFMLRQFEISRLVGIRPYNAIAFSGPIAVFVSVFLMYPLGQSSWFFAPSFGVAGIFRFILFLQGFHNWTLNPFHMMGVAGILGGALLCAIHGATVENTLFEDGEDSNTFRAFEPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSSVGIVGLALNLRAYDFVSQELRAAEDPEFETFYTKNILLNEGMRAWMAPQDQPHENFIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: UGPE_BRUSU
Sequence: MIEQRPVSNLIGHLILILGIIIVAFPIYYTFVASLMTSTQIIRPPISLLPGDHLVENYREAIFGGVERVVGVSLERLLWNSFVVAMAIAVGKIIISFMSAFAIVFFRFPMRMFFFWMIFITLMLPVEVRILPTYKVIVDLGMIDTYAGLTLPLMASATATFLFRQFFLTIPGELVEAARIDNAGPFRFMRDILLPLSKTNIAALFVILSIYGWTQYLWPLLVTNDAKMNTIIIGLRRMVDWADASTSWNYVMVTAILAIIPPILVVVLMQRWFVKGLVETEK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROB_STRPD
Sequence: MMKRQFEDVTRIVIKIGTSSLVLPTGKINLEKIDQLAFVISSLMNKGKEVILVSSGAMGFGLDILKMEKRPTNLAKQQAVSSVGQVAMMSLYSQIFAHYQTNVSQILLTRDIVVFPESLANVTNAFESLISLGIVPIVNENDAVSVDEMDHATKFGDNDRLSAVVAGITKADLLIMLSDIDGLFDKSPTIYEDAQLRSHVAVITQEIIASAGGAGSKFGTGGMLSKVQSAQMVFENKGQMVLMNGANPRDILRVLEGQPLGTWFKQIEEVRHD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS23_RAT
Sequence: MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  Plays an important role in translational accuracy.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: RUFY4_HUMAN
Sequence: MAEEGAILKVTKDLRAAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTALRRQRGNMEPIHFVRSQDKLKTPLGKGRAFIRFCLARGQLAEALQLCLLNSELTREWYGPRSPLLCPERQEDILDSLYALNGVAFELDLQQPDLDGAWPMFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT
What is the function of this protein?
Positively regulates macroautophagy in primary dendritic cells.  Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes.  Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.
What are the official names of this protein?
RUN and FYVE domain-containing protein 4.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome.
Protein: HIS6_HYDCU
Sequence: MSLAKRIIPCLDVDNGRVVKGVQFVDIRDAGDPVEVAKRYDEQGADEITFLDITATAHERDTIVHVVEEVASQVFIPLTVGGGIRSIEDVRTMLNAGADKVAINSAAIFNPAFVKEACDTFGSQCIVVAIDAKKVSPKGEPDKWEIFTHGGRKETGIDAVEWAKEMETLGAGELLVTSMDKDGTKSGFDLALTRTISDSVKIPVIASGGVGKLSDLCDGITQGHAEAVLAASIFHFGEHTVQEAKQAMQKEGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNRF1_MOUSE
Sequence: MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFSLYTPASRGTGDSERAPGGGGSTSDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation.  Plays a role in the establishment and maintenance of neuronal transmission and plasticity.  Regulates Schwann cells differentiation by mediating ubiquitination of GLUL.  Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons.
What are the official names of this protein?
E3 ubiquitin-protein ligase ZNRF1, Nerve injury-induced gene 283 protein, RING-type E3 ubiquitin transferase ZNRF1, Zinc/RING finger protein 1.
What are the subcellular locations of this protein?
Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons.
Protein: S6A15_PONAB
Sequence: MPKNSKVVKRELDDDVTESVKDLLSNEDSADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWSSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRALLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSQTIMKFLKMGNISQDIIPHHINLSAVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYVSPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAVLPVPVVFIVRRFNLIDDSSGNLASVTYKRGRVLNEPVNLEGDDTSLIHGKISSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADIMPDMPESDL
What is the function of this protein?
Functions as a sodium-dependent neutral amino acid transporter.  Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine.  Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid.  Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1.  May have a role as transporter for neurotransmitter precursors into neurons.  In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
What are the official names of this protein?
Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium- and chloride-dependent neurotransmitter transporter NTT73, Solute carrier family 6 member 15, Transporter v7-3.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HELZ_HUMAN
Sequence: MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESLLYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLTGESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
What is the function of this protein?
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
What are the official names of this protein?
Probable helicase with zinc finger domain, Down-regulated in human cancers protein.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGJ_RHILO
Sequence: MSTTISPLAPKKYPKMPVIEGVRIATAEAGIKYKNRTDLLAMVFDAGTAVAGVFTKSKCPSAPVDFCRQNLAAGKARVLVVNSGNANAFTGKKGRESTALTGEAAAKAAGCTAGEVFLASTGVIGEPLDTTKFSHLLAGLVSDGKPDLWTEAAKAIMTTDTYPKVATQTVKLGDTDVTINGISKGAGMIAPDMATMLSFIATDAPIAAPVLQDLLSRGTAKTFNAVTVDSDTSTSDTLLIFATGKAAKRGAPEITDPKDARLGQFRRALGKVLKSLALQVVRDGEGARKQVEVTVTGAKSARSAKRIALSIANSPLVKTAVAGEDANWGRVVMAVGKAGEPADRDRLSIWFGDIRLAHEGERDPGYSEEATSTYMKRDDIRIRADIGIGRGKATVWTCDLTKEYVAINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAS_STAAN
Sequence: MADLLNVLKDKLSGKNVKIVLPEGEDERVLTAATQLQATDYVTPIVLGDETKVQSLAQKLDLDISNIELINPATSELKAELVQSFVERRKGKATEEQAQELLNNVNYFGTMLVYAGKADGLVSGAAHSTGDTVRPALQIIKTKPGVSRTSGIFFMIKGDEQYIFGDCAINPELDSQGLAEIAVESAKSALSFGMDPKVAMLSFSTKGSAKSDDVTKVQEAVKLAQQKAEEEKLEAIIDGEFQFDAAIVPGVAEKKAPGAKLQGDANVFVFPSLEAGNIGYKIAQRLGGYDAVGPVLQGLNSPVNDLSRGCSIEDVYNLSIITAAQALQ
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EDEM3_MOUSE
Sequence: MSKAGGCRGCGCRVPQRASWSLVAATAALCLVLATSVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEHMQWYNDELLHMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRDPEMENEDQPSSENDSQNQSAEQMLSLSQTVDLADKESPEHPADSHSEASPSDSEEAAGFAPSEQISGSTENHETTSLDGECTDLDNQVQEQSETEEDSSPNVSWGTKAQPIDSILADWNEDIEAFEMMEKDEL
What is the function of this protein?
Involved in endoplasmic reticulum-associated degradation (ERAD).  Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans.  May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952).  May have alpha 1,2-mannosidase activity.
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 3, Alpha-1,2-mannosidase EDEM3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: NHAA1_CAMJD
Sequence: MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGLELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLLSLAIFDDVGAILIIAIFYTTKLSIVAFVVAGIAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIITAFFIPMQTKNGEAFLEEIYESLKFWLAFVILPLFAFANAGVNLSNIDIGAVFSGVSIGIFLGLFVGKQVGVFLFSYLVIRFKFAALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFAARS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_ECOSM
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SUI1_METLZ
Sequence: MNSGICPKCGLPKELCICEEVAKEQQRISVKVSKRRYGKEVTVVDGLDPYEIDLEDLSKFLKGRLACGGTVKENSIELQGNHRDRVKALLTSRGYSLENIN
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.