PharMolix/UniProtQA huggingface dataset:
Protein: CYAC3_BOVIN
Sequence: MAVGWFYLSVLALCSLGSMCILFTIYWMRYWHGGFAWDGSMLMFNWHPVLMVTGMVVLYSAASLVYRLPQSWVGPRLPWKSGHAAMHLLAFLLTVLGLHAVFEFHNHAKIPHLYSLHSWLGITTVFLFACQWFLGFSVFLLPWASMWLRSLLKPIHVFFGASILSLAIASVVSGINEKLFFSLKNGTKTYSNLPSEAVFANCAGMLVVVFGLLVLYILLASSWKRPEPGMQAEREPTRTRGRAGTPEVMLEGERGLAEPLLQKRS
What is the function of this protein?
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome.  Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters.  It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.
What are the official names of this protein?
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3, Cytochrome b ascorbate-dependent protein 3, Lysosomal cytochrome b, LCytb.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: UXAC_ECO27
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: COAA_PHOLL
Sequence: MNKKEPFLATPYLQFNREQWATLRDSVPLTLTKEELIDLKGINEEISLEEVVEIYLPLSRLLNFYISSNLRRQAVLEQFLGTDGQKVPYVIGIAGSVAVGKSTTARLLQALLSRWPEHRSVELITTDGFLHSNSVLNERGLMKKKGFPQSYDMHSLVKFVSDIKSGSKQVSAPVYSHLTYDIVPNEQKFIKQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEKLLKSWYISRFLKFRQGAFSDPDSYFHSYSKLSEEEAINTASDIWQEINGLNLRQNILPTRERASLIMTKGTNHTIESVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YP126_YEAST
Sequence: MLARVAESVSCGLMGQVKTGLLLFDGSGFSDRLGVMRFYVWSSRIYVLVLVVQAQLILDAHNGVLFLLLFFLHNFFLLPQLFQFLLSGCLIFLNDVYFNLMV
What are the official names of this protein?
Putative uncharacterized protein YPR126C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RPOY_STRT2
Sequence: MIYKVFYQETKERSPRREQTKSLYLDIDAETELEGRIQARQIIEKNTAYNIEFIELLSEKALEYEKETGVFEVTEF
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: PCNA_PEA
Sequence: MLELRLVQGSLLKKVLESIKELVNDANFDCSSTGFSLQAMDSSHVALVALLLRSEGFEHYRCDRNLSMGMNLNNMAKMLKCAGNDDIITIKADDGSDTVTFMFESPTQDKISDFEMKLMDIDSEHLGIPEAEYHAIVRMPSAEFARICKDLSSIGDTVVIAVSKEGVKFSTKGDIGSANIVCRQNTTVDKPEEATVIEMNEPVALQFALRYMNSFTKATPLSSSVTISLSNELPVVVEYKIAEMGYVRFYLAPKIEEDEEETKPQA
What is the function of this protein?
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
What are the official names of this protein?
Proliferating cell nuclear antigen.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y059B_ATV
Sequence: MKMRVVSFKAEEDLLVLLDRYAMKYKLNRSEAIRKAIENLVKDEVSEGTVARVEKILLW
What are the official names of this protein?
Uncharacterized protein ORF59b.
Protein: HN423_CYRHA
Sequence: DCAGYMRECKEKLCCSGYVCSSRWKWCVLPAP
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1r, U3-TRTX-Hhn1r, Hainantoxin F4-23.43, Peptide F4-23.43.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 16 (Hntx-8) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AROC_PYRAB
Sequence: MRGRVLSFTLFGESHGKGVGVVITGIPPGIKVSHEELVKELERRKGIPGLSTARSEPDNPIILSGIFRGYTTGTPIAVLFENKDVDSSYYEDIKDKPRPGHADYPARIKYFGYNDYRGGGHFSGRLTVGIVTAGYFAKKILEKYGIRIRAYIKRIGRVEAKQLTLEEILSSENPFCPDEEAFEKMVEEIELARREGDSVGGIVEVVAVNVPPGLGGPYEEDIEADLASAFFRIPAVKGVEFGLGFKVAEKRGSEVNDPYVIRDGKVVTKTNNHGGVLGGITTGMPIIARIAFKPTPSIYLPQRTVDLREMKEVEIKLRGRFDPSIVPRALPVVEGVMAFVLADHLLFRRVWELKSS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NRDI_SALNS
Sequence: MSALVYFSSSSENTHRFMQRLGLPATRIPLNERERIRVDEPYILVVPSYGGGGMAGAVPRQVIRFLNDEHNRARIRGVIASGNRNFGDAWGCAGDVIAQKCGVPWLYRFELMGTQRDIDNVRKGVNEFWQQLPRSA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: AN32E_DANRE
Sequence: MEMKKRISLELRNRTPAEVAELVVDNCRSSDGEIEGLTDDFKELEFLSMVNVGLTSLAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDLFNCEITTLEDYRESIFELLPQVTYLDGFDAEDNEAPDSEADDDDDDEDGDEGAGQLGEYEEEEEEDEEGSEGGEVGLSYLMKEDIQDEEDDDDYVEEEEEEGGEEEADVRGEKRKREAEDEGEDDDEDDD
What is the function of this protein?
Histone chaperone that specifically mediates the genome-wide removal of histone H2A. Z/H2AZ1 from the nucleosome: removes H2A. Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions.  Not involved in deposition of H2A. Z/H2AZ1 in the nucleosome.  May stabilize the evicted H2A. Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state.  Inhibits activity of protein phosphatase 2A (PP2A).  Does not inhibit protein phosphatase 1.  May play a role in cerebellar development and synaptogenesis (By similarity).
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member E.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UBIX_PYRHO
Sequence: MKIIVAITGASGSIYGIKLYEILKKLGHDVILLASKTGIKVAKYETGMEITPDFDEDDLFAPIASGSYPFDAMVIAPCSMKTLGAIANGFSYNLITRAADVTLKERRKLILLIRETPLNLVHVQNMLKIIQAGGIIMPASPAFYTKPKTIDDMVNFIIGKILDLLGITHNLYRRWGMREDD
What is the function of this protein?
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD.  The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
What are the official names of this protein?
Flavin prenyltransferase UbiX.
What is the protein family that this protein belongs to?
Belongs to the UbiX/PAD1 family.
Protein: MSRA_METM5
Sequence: MTNTETAVFGMGCFWSAEELFRKIKGVISTEVGFMGGTVKNPTYGQVCRGKSGHIEVVNITYNPKIVKYTDLLNLFWNNHDPTTPNRQGWDVGEQYSSHIFYFTEEQRLLAEKSFEKIQKSSDLRIVTAIKKASDFFPAEEYHQKYFMKKNNSILNF
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: PG045_VACCT
Sequence: MLSMFMCNNIVDYVDDIDNGIVQDIEDEASNNVDRDYVYPLPENMVYRFDKSTNILDYLSTERDHVMMAVRYYMSKQRLDDLYRQLPTKTRSYIDIINIYCDKVSNDYNRDMNIMYDMASTKSFTVYDINNEVNTILMDNKGLGVRLATISFITELGRRCMNPVKTIKMFTLLSHTICDDCFVDYITDISPPDNTIPNTSTREYLKLIGITAIMFATYKTLKYMIG
What is the function of this protein?
Plays a role in evading host innate immune response by inhibiting host inflammasome activation.  Interacts with and inhibits NLR-mediated interleukin-1 beta/IL1B production in infected cells.  At the host mitochondria outer membrane, interacts with the BH3 domain of host BAK and prevents BAK from binding active BAX.  In turn, host apoptosis is inhibited.
What are the official names of this protein?
Apoptosis regulator OPG045, Protein F1.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG045 family.
Protein: DI3L2_CAEEL
Sequence: MSAVESPVIVTEPGSLKPQGLTQTATGGKFGAAATVKTTPTKAKPYVKPQNANNLQNNFNPRKIFTEYISKEETDAGIEDGSMFKGVLRINPKNYQECFLDHPKGTNHPDVLVLGQDRNRAMQGDVVAVKIKPKEDWLVNYVEYVKWWAEHKKGDRNSGKTDNNSPNKTEKRCLRNEIQDNGVTSDEVPDSCLITIGAIVHILEKKHFRVAAGKLQLMPNSANPNVLFVATDSRVPRILIPKSDVDKEFFSRPKDFERFLYTAKITDWRAESVYADGRLVKLLGMSGEIDTETERIVYEHQIDHREFSDECLESLPITTAENWKVPDAEFEYRRDFRSDIVFTIDPKTARDLDDALHAKHIDDCDGKGTPGLEIGVHIADVTFFLKEGTELDKWASERGNSTYLSQTVIPMLPRILCEQLCSLNPGVDRLSFSTVFKMSYEAELYDVWFGRSVIRSRVKLAYEHAQDFIENPEKDFTCDELPDISDGNTPFEIKEKTLMLHRIAQVLRQKREDSGALRIELPRLKFALDEDKKPQGVSIYEIKDSNKLVEEFMLLANMEVAKKIAENFPEHALLRNHPPPKEKMIKDVAEQCARIGFPLDGRTSGLLSTSLRKYQGKSRLDMCIRQVISSLTIKPMQQAKYFCTFEMPLSFYHHFALNVDHYTHFTSPIRRYPDVIVHRQLAAALGYNERSERVPEEIQEICTRCNDTKLASKEASDESAMLYFGVFIHQTGPMKCQAVVLGVMDLSFDVLIVEYGVVKRVYVDKMKRDFNKSTEKLTIYWPADPNAESGNREEFSSSIQMCNVVYVILVPYKSIEVSATIVRPSLEQRNILKSTLKDMKETGSTILQ
What is the function of this protein?
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation.  Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
What are the official names of this protein?
DIS3-like exonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body.
Protein: FEN1_ENTBH
Sequence: MGIKRLSKLIKTYCSEGVQNRELKYYSGYKIAIDASMCIYQFLVAVRAEGQSLSWGDSTTSHISGIFYRSIRWIENGIIPVFVFDGIPPEEKIHEFEKRTKRRQDINAKLQDAIEQQDQVLVSKYDRMNVKMEKSHIEECQKTLRLLNIPYVIAPSEAEAYCAWLCKSKFVDAVATEDMDSLCFGSPLLLRNFNTALSQKLPVEEYNLHKILEGLQFTMEQFVDLCILLGCDYSATIRGVGMKRAFEYIKKYKSIDNLIGIVDFPDDFKYKEARTIFFTLGTDTSNNFTNENPINTNIATWDLIAVDSASINIEAVIDFLCNEKGFDKGRIETGIKKLQKQKKVNKQTRIDSFFKKKL
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: MSCL_ERWT9
Sequence: MSMFKEFRDFAMRGNVVDLAVGVIIGAAFGKIVSSLVANIIMPPLGLLIGGVDFKQFSWILKPADGAAPAVVMEYGVFLQTVFDFVIVAFAIFMAIKLMNRLYTKKEVEKPVAKPSAEETLLSEIRDLLKEQNGKAQ
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUA_MOOTA
Sequence: MPCLKITLAYDGSNYAGWQVQPEAHGPTVQGEVAAALKRLTGEEITPVAAGRTDAGVHARGQVISFSTRARIPVERWPLALNSVLPADIAALEAVEVAPDFHARYCAKRKWYRYTIYNNRVPDVFCRRYSWHLRQPLDVIAMARAAAYLQGCHDFRSFCAAGSPVRHFERQVQQASVSQNGPFIYFDVIADGFLYHMVRIMVGTLVEIGRRRLVPEAIPAILAARSREKAGPTAPARGLCLERVEY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PSB4_XENLA
Sequence: ESVARGTAPGELHCFPGAGPVRHTLNPMVTGTSVLGVKFDGGVIIAADMLGSYGSLARFRNISRIMKVNENTILGASGDYADYQYLKQVIDQMVIDEELVGDGHNYSPKAIHSWLTRVMYNRRSKMNPLWNTVVIGGFYNGESFLGYVDKLGVAYEAPTIATGFGAYLAQPLLREVTENKATLSKEEARQLVDRCMKVLYYRDARSYNRFEITTVTESGVEVEGPLSSETNWEIAHLISGFE
What is the function of this protein?
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit beta type-4, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: END8_ECO55
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKTYQSQLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTSEEPQTTRVLRVKLQTADKTILLYSASDIEMLRPEQLTTHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLEIPRFSYATRGQVDENKHHGALFRFKVFHRDGELCERCGGIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SAMH1_MOUSE
Sequence: MDSLLGCGVSAAAREPVPRYLTSQPRVSEVAMQSAPLEQPAKRPRCDGSPRTPPSTPPATANLSADDDFQNTDLRTWEPEDVCSFLENRGFREKKVLDIFRDNKIAGSFLPFLDEDRLEDLGVSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALAEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKADPYVEITGTAGKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDKNPIDRVHFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCKKKDGKSLDAAGKHFVQWCALRDFTKPQDGDIIAPLITPLKWNNKTSSCLQEVSKVKTCLKF
What is the function of this protein?
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity).  Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:23972988, PubMed:23872947, PubMed:26667483, PubMed:31548683, PubMed:29379009).  Likewise, suppresses LINE-1 retrotransposon activity (PubMed:26667483).  In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity).  Phosphorylation at Thr-634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (By similarity).  Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (By similarity).  Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (By similarity).  Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity).  Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (PubMed:29669924).
What are the official names of this protein?
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, Interferon-gamma-inducible protein Mg11, SAM domain and HD domain-containing protein 1, mSAMHD1.
What is the protein family that this protein belongs to?
Belongs to the SAMHD1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to sites of DNA double-strand breaks in response to DNA damage.
Protein: RISB_SHEB9
Sequence: MNVVQGNIEAKNAKVAIVISRFNSFLVESLLEGALDTLKRFGQVSDDNITVVRVPGAVELPLAARRVAASGKFDGIIALGAVIRGGTPHFDFVAGECNKGLAQVALEFDLPVAFGVLTTDTIEQAIERSGTKAGNKGGEAALSLLEMVNVLQELEQQLL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: NDHI_RENSL
Sequence: MFPMVTEFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTIFNLPEIKP
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: LARK_DROME
Sequence: MPGAGTFKLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY
What is the function of this protein?
Essential RNA-binding protein.  May be required for circadian repression of eclosion.  Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development.
What are the official names of this protein?
RNA-binding protein lark.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The precise location within neurons varies according to the type of neuron, being cytoplasmic in CCAP neurons and nuclear in the CNS.
Protein: MOAA_TRIEI
Sequence: MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFRLTGGEPLLRPNVIGLIEAIASFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLDSDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVIIPGVNDHEVLDLAALTINRNWHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGTLGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLLGLKPEINFKQRESGTTGIYSRTMSQIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: PSAC_GUITH
Sequence: MSHSVKVYDTCIGCTQCVRACPCDVLEMVAWDGCKAGQIASAPRTEDCIGCKRCETACPTDFLSVRVYLGGETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.