PharMolix/UniProtQA huggingface dataset:
Protein: ATPL_BACAN
Sequence: MSLGVIAAAIAIGLSALGAGIGNGLIVSRTIEGVARQPELKGALQTIMFIGVALVEALPIIGVVIAFIVMNK
What is the function of this protein?
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient.  F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRX1_SCHPO
Sequence: MVKQVSDSSEFKSIVCQDKLVVVDFFATWCGPCKAIAPKFEQFSNTYSDATFIKVDVDQLSEIAAEAGVHAMPSFFLYKNGEKIEEIVGANPAKLEASIKANL
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin-1, TR-1, Trx-1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: EFG_NITSB
Sequence: MARKTPIEKVRNIGIAAHIDAGKTTTTERILYYTGISHKIGEVHEGAATMDWMDQEKERGITITSAATTCFWKDHQINIIDTPGHVDFTIEVERSMRVLDGAVAVFCAVGGVQPQSETVWRQANKYHVPRIVFVNKMDRIGADFYNVENQIRERLKANPVPIQIPIGAEDNFRGVVDLVEMKGIVWDDETMGAKYEVIDIPEELREKAEEYREKLVEAVAETDEELLDKYLGGEELTTEEIKKGIKKGTLDMTITPMLCGSAFKNKGVQTLLDAVVDYLPAPTEVSWIKGIDPKTGEEVSVESTDNGPFAALAFKIMTDPFVGQLSFIRVYRGQIASGSYVLNSTKEKKERVGRLLKMHANKREEIKELPAGEIGAVVGLKYTLTGDTLCDESHPVILEKMEFPEPVISVAVEPKTKADQEKMATALAKLAEEDPSFRVHTDEETGQTIISGMGELHLEIIVDRMKREFKVDAEVGQPQVAYRETIKAPVDQEYKYAKQSGGRGQYGHVFIKLEPQEPGKGYEFVNNITGGVIPKEYIPAVDKGIQEAMQNGVLAGYPVVDIKATLYDGSYHDVDSSEMAFKIAGSMAFKEAAKKANPILLEPIMKVEVEVPEEYMGDVIGDINRRRGQVQSMEDRAGNKIVTAMVPLAEMFGYSTDLRSFTQGRGTYSMEFDHYEEVPKNVADEIIKKRNG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROBO4_MOUSE
Sequence: MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS
What is the function of this protein?
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning.  May mediate the inhibition of primary endothelial cell migration by Slit proteins.  Involved in the maintenance of endothelial barrier organization and function (By similarity).
What are the official names of this protein?
Roundabout homolog 4.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ROBO family.
Protein: MTNA_SYNAS
Sequence: MSASFTTIAWRNDAVLLLDQQALPGEERYLTCTRFEEVLTAIRDLTVRGAPAIGVASAMGIALGALSLPDDSPEAFCNGFEALCDRFAQARPTARNLFWAVERMKRCFGEHFHPDTSSECSSAAPGKEIARTLAAVRKALVAEARRMAEEDVAINRRIGHYGQVLIRDGYRILTHCNAGALATAGYGTALGVIRAAREAGKQVQVFADETRPVLQGARLTAWELQKENIPVTLITDSMAGFLMKQGRIDCILVGADRIATNGDTANKIGTYTLAVLAAAHSVPLYVAAPLSTIDRKLSSGNEIPIEERPAEEILTIRGVPIAPAGVEVYNPAFDVTPGHYISAIITEAGIAEFPYESSLERLFLSFP
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: TAOK2_RAT
Sequence: MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPLSTGTLSEEQPCSSGQEAILGQRMLGEEEEAVPERMILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDWDISKEMKESRVPSLASQERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIGTPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFLLLAQGTALGAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMRRGISRLWLRVLLRLSPMVFRALQGCAAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPRTTQHPLALLARVWALCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQRRLGLSASRQLPPGTVAGRRSQTRRALPPWR
What is the function of this protein?
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade.  Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins.  Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.  In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.  May affect microtubule organization and stability.  May play a role in the osmotic stress-MAPK8 pathway.  Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation.  Isoform 2, but not isoform 1, is required for PCDH8 endocytosis.  Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2.  This process leads to PCDH8 endocytosis and CDH2 cointernalization.  Both isoforms are involved in MAPK14/p38 MAPK activation.
What are the official names of this protein?
Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Note=Found to be perinuclear and localized to vesicular compartment. SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8.
Protein: VIF_HV1Y2
Sequence: MENRWQVMIVWQVDRMRIRAWKSLVKHHMYISGKARGWFYRHHYESPHPRISSEVHIPLGDAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADQLIHLYYFDCFSESAIRKAILGYRVSPRCEYQAGHNKVGSLQYLALTALITPKKTKPPLPSVKKLTEDRWNKPQKTKGHRGSRTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: TIG_BACLD
Sequence: MSVKWEKQEGNEGVLTVEVDADTFNKALDDAFKKVVKQVSIPGFRKGKVPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGENLIFTAKVTVKPEVKLGEYKGLGIEKDDTAVTDEDVQNELKSLQERQAELVVKEDGKVEEGDTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVTFPEEYHAEELAGKPAVFKVKIHEIKAKELPELDDEFAKDVDEEVGTLAELTEKTKKRLEEAKENEADAKLREELVLKAAENAEADIPQAMIDTELDRMMKEFEQRLQMQGMNLELYFQFSGQDENALKEQMKEDAEKRVKSNLTLEAIAKAENLQVTDEEVEEELSKMAEAYNMPVENIKQAIGSTDGMKEDLKVRKAIDFLVENR
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: DNLJ_ALKCK
Sequence: MDKHQAEKRLKELRLLLEDYGYHYYVLDTPKVPDSEYDRLMNELLQLEADYPDLVTEDSPSVRIGGPPAPSFKKVAHRVPMMSLSNAFNEEDLRAFDRRVRQAVGEHVSYVCELKFDGLAVSLTYENGKLVRGATRGDGTIGEDITNNLRTVPAIPLRLKQPYSIEVRGEAYMPKASFERLNEAKEQAGEEKFANPRNAAAGSLRQLDPKIAAKRNLSLFAYSIGEVEGKNVQTHFDSLMFLKELGFKVNEEAAECETIEDVIAYTEKWSERRHELPYEIDGVVVKVNSLADHEKLGFTAKSPRWATAFKFPAEEVLTVLRDIELNVGRTGVVTPTALLDPVLVAGTTVRRASLHNEDLIREKDVKLGDTVIVKKAGDIIPEVVGVLTDKRTGEEVDFHMPTECPECHSVLERLEGEVALRCLNPKCPAQIREGLIHFVSRNAMNIDGLGEKVISQLFLHQLIADVADLYLLEREELLQLERMGEKSVDNLLAAIEASKENSLERLLFGLGIRFVGAKAAKTLAYEFETMERLQEATFEQLLAVNEIGEKMADSIVSYFQKPEVATLLEKLANAGVNMTYTGPKKAAIAEEAGVFAGKTVVLTGKLSQWTRKEAQEKIEALGGTVTGSVSKKTDLVVAGEDAGSKQKKAESIGIEIWTEEQFTQAVEQSEQ
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ATPL_ACIBY
Sequence: MELTLGLVAIASAILIAFGALGTAIGFGLLGGRFLEAVARQPELAPQLQTRMFLIAGLLDAVPMIGVGIGLFFIFANPFVG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYC_CHLRE
Sequence: MSTFAEAPAGDLARGEKIFKTKCAQCHVAEKGGGHKQGPNLGGLFGRVSGTAAGFAYSKANKEAAVTWGESTLYEYLLNPKKYMPGNKMVFAGLKKPEERADLIAYLKQATA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: SOL3_YEAST
Sequence: MVTVGVFSERASLTHQLGEFIVKKQDEALQKKSDFKVSVSGGSLIDALYESLVADESLSSRVQWSKWQIYFSDERIVPLTDADSNYGAFKRAVLDKLPSTSQPNVYPMDESLIGSDAESNNKIAAEYERIVPQVLDLVLLGCGPDGHTCSLFPGETHRYLLNETTKRVAWCHDSPKPPSDRITFTLPVLKDAKALCFVAEGSSKQNIMHEIFDLKNDQLPTALVNKLFGEKTSWFVNEEAFGKVQTKTF
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase 3, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EGL15_CAEEL
Sequence: MSYFLASCLGVGLLSTVSCSLQGLTSHYRENIPRFKHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVPVHDSEESPSESRTEFINADEKENKEDEEEDYSVSQPVAPDAGLTELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNEFMAIHLLTGDEPKIDRWTTSDYIFTTILLFLLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQIIETPITKKEAARKQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDDYESNFSVEPPNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF
What is the function of this protein?
Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.
What are the official names of this protein?
Myoblast growth factor receptor egl-15, Egg-laying defective protein 15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PUR7_YERPA
Sequence: MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLANDVLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CH60_RAT
Sequence: MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
What is the function of this protein?
Chaperonin implicated in mitochondrial protein import and macromolecular assembly.  Together with Hsp10, facilitates the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.  The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring.  In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10.  This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components.  Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
What are the official names of this protein?
60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, Chaperonin 60, CPN60, HSP-65, Heat shock protein 60, HSP-60, Hsp60, Mitochondrial matrix protein P1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: YGDR_SHIFL
Sequence: MKKWAVIISAVGLAFAVSGCSSDYVMATKDGRMILTDGKPEIDDDTGLVSYHDQQGNAMQINRDDVSQIIER
What are the official names of this protein?
Uncharacterized lipoprotein YgdR.
What is the protein family that this protein belongs to?
To E.coli YgdI.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CHLN_ACAM1
Sequence: MTLADAQPQALDFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDISAKLNDYEELKRLCMQIKRDRNPSVIVWIGTCTTEIIKMDLEGLAPRLESEIDIPIVVARANGLDYAFTQGEDTVLAAMAHRCPKGSAVVEESEKQERGNAITSLLNFGKKKEEVVAEESEYHDHAPLVMFGSLPDPVVTQLTLELKKQGIKVNGWLPAKRFTELPVIDEGYYVAGVNPFLSRTATTLMRRRKCKLIGAPFPIGPDGTRAWIEKICSVLDVEPKGLEEREAKIWANLEDYLEIIRGKSVFFMGDNLLEVSLARFLIRCGMTCPEIGIPYMDKRYQGAELKFLEQTCIDMGVPMPKIVEKPDNYNQVQRIYEHDVDLVITGMAHANPLEARGINTKWSVEFTFAQIHGFTNARDILELVTRPLRRNNSLKDLGWDKLVKEEAKV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: FABZ_CUPMC
Sequence: MTASEIDIRKILKLLPHRYPILLVDRVLEFEPQKRIKTLKNVTINEPYFMGHFPDQPVMPGVMILEALAQSAGLLTFGADMERKEGALYYFVGIDGARFKRVVYPGDQLHLNVTVERYIRGIWKFKASATVDGEVACEAELMCTVKQAEG
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_XYLFT
Sequence: MIKKTILNDTHQALGAKMVDFSGWEMPIHYGSQIDEHHHVRRNAGIFDVSHMTVIDLHGTQVRPLLRRLLANSVDKLKVPGKALYSCMLNPQGGVIDDLIVYYLREDYFRFIVNAATREKDLAWINTQASAFNVRVEERADLAMLAVQGPAARAQVTNLLAETHRDAVEKLGRFAALEVASHSKKPLFISRTGYTGEDGFEILLPQEETITLWNALLKTGVKPIGLGARDTLRLEAGMNLYGQDMDEQVSPYEAALGWTVMLDEGRNFIGRNVLEQQKTNGVSRQMIGLLMDEKGVLRHGQKVLTAQGEGHILSGTFSPTLNKAIGFARVPAGKPSEVRVNIRDREIPVRVVKFPFVREGQTQPNIFD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: APT_FRASN
Sequence: MTSVDSQPDLSAAEAVLGAHVRDVMDFPKPGVVFKDITPLLSTPAAFGVVVGALADLARGLGATTIAGIEARGFLLAAPVADRVGAGIVPIRKQGKLPGRTRSEAYALEYGTAVLEIHEDAVPTGERVLIVDDVLATGGTAAAAHTLLRGCGADVVGLAVLMELTFLSGRDRTGTLDVTSIMKI
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUL4_ARATH
Sequence: MGISFSNNNRRRDNNNRRHLHHYPPPPPYYYLDPPPPPPPFPPHYDYNYSNYHLSPPLPPQPQINSCSYGHYHYHPQPPQYFTTAQPNWWGPMMRPAYYCPPQPQTQPPKPYLEQQNAKKVRNDVNVHRDTVRLEVDDLVPGHHLVSFVFDALFDGSFTITFFAKEEPNCTIIPQFPEVYSPTRFHFQKGPGQKFLQPSGTGTDLSFFVLDDLSKPLEEDVYPLVISAETIISPNSISEQSSVHKQVTQAVLEKDNDGSFKVKVVKQILWIEGVRYELRELYGSTTQGAASGLDESGSGTECVICMTEAKDTAVLPCRHLCMCSDCAKELRLQSNKCPICRQPIEELLEIKMNSSDEQH
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro).
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase LUL4, Probable RING-type E3 ubiquitin transferase LUL4, Protein LOG2-LIKE UBIQUITIN LIGASE 4, RING finger protein 208.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. LOG2 subfamily.
Protein: RBL_HEDHE
Sequence: SVGFKAGVKDYRLTYYTPDYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYGIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPXHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVSXAEALYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMTFRVLAKGLRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVXHMPALTEIFGDDSVLQFGGGTLGHPWGNRPGAVANRVALEACVQARNEGRDLAREGNEIIREAAKWSPELAAACEVWKEIKFEFAAMDVL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.