PharMolix/UniProtQA huggingface dataset:
Protein: RL32_SHIB3
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: BAEC_BACVZ
Sequence: MITYLFPGQGSQKQGMGSSLFDEFKDLTEQADETLGYSMKRLCLENPYSNLHKTQFTQPALYVVNVLSYLKKIQDNDIKPDYVAGHSLGEYNALFAAGAFDFITGLQLVRKRGELMSMATDGKMAAVMGLTAAQVSDALQTHGLHTIDIANMNSPHQVVISGRKEDIERAKSVFEGLKDVTMFHPLNVSGAFHSRYMSEAKQEFEKFLQSFHFSAISIPVISNVHARPYEQDGIHSVLADQIDHSVRWNDSIRYLLDKGRMEFEEVGPGHVLTGLIHRIKNETEASPAM
What is the function of this protein?
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.  It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) (By similarity).
What are the official names of this protein?
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC, AT.
What is the protein family that this protein belongs to?
Belongs to the FabD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_BORRA
Sequence: MAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPIVTKDGVSVAREIDLENSFENMGAQLLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDHAVALAAEKIRKSAKKITTKEEIAQVASISANNDTSIGEKIAEAMDRVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDTYILICEKKISTIKELLPVLEKVVNTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDIAILTGGVLVSEELGLTLENVELEQLGQAKSVKVDKDNTTIINTGNREQIRERAELIKKQIEETSSEYDKEKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVPGGGSTLIEVAMYLDTVDVSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFESSIYIHQIKTDKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITEIKEEKNSAGGNYPMDPGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NMT1_BOVIN
Sequence: MGDESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNNLQYYLYNWKCPSMGAEKVGLVLQ
What is the function of this protein?
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
What are the official names of this protein?
Glycylpeptide N-tetradecanoyltransferase 1, Myristoyl-CoA:protein N-myristoyltransferase 1, NMT 1, Type I N-myristoyltransferase, Peptide N-myristoyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the NMT family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes.
Protein: SCPA_STRPF
Sequence: MDIKLKDFEGPLDLLLHLVSQYKVDIYEVPIVEVIEQYLNYIETLQVMKLEVAGDYMLMASQLMLIKSRRLLPKVVEHIEEEDLEQDLLEKIEEYSRFKAVSQALAKQHDQRAKWYSKPKQELIFEDAILQEDKTVMDLFLAFSNIMAAKRAVLKNNHTVIERDDYKIEDMMASIKQRLEKENVISLSAIFEECQTLNEVISIFLASLELIKLHVVFVEQLSNFGAIILRKEKK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: THIE_LARHH
Sequence: MKKMIDYSVYLVLDPELCGGLDGMLRVTEAAMAGGAGVVQLRAPQWKKRQWLDAARALQPLCRQGGAVFVVNDQVDVALAVGADGVHVGQQDLPVAVVRELMGPQALIGLSVNHAGQLAAVPSEADYLGLGPVFATSTKKDAAPVLGLAQLAGLAAATSLPTVGIGGIAPANAGAVFAAGVDGVAVVSAICTAADPAAVTRELYALKGHTA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: PAE3_ARATH
Sequence: MKSVLRIAAAIFWLWLFIVLGVIGSGNVRDTDDEISLLESQLVVTSPSQLLMVPLTLIQAAASKGAVCLDGTLPGYHLHPGSGSGANRWLIQLEGGGWCNTRRSCIFRKTTRRGSSNHMEKVLAFTGILSNKSNENPDFFNWNRVKLRYCDGASFTGDSQDESSQLYYRGQRIWHSAMEELLSKGMQKAEQALLSGCSAGGLASILHCDQFKELFPGTTTVKCLSDAGMFMDAVDVSGGHSLRKMFQGVVTVQNLQKELSTACTKHLDPTSCFFPQNLVSGIKTPMFLLNAAYDAWQVQESLAPPSVDLSGSWKACKSDHSHCNSSQIQFFQDFRTHMVDAVKSFATSTHNGVFINSCFAHCQSERQDTWYAPDSPTLHGKTVAESVGDWYFDRTTVKAIDCPYPCDKTCHNLIFK
What is the function of this protein?
Hydrolyzes acetyl esters in homogalacturonan regions of pectin.  In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions.  Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
What are the official names of this protein?
Pectin acetylesterase 3.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: PAND_CLOBK
Sequence: MTITMLKSKIHRATVTEANLNYVGSITIDKYLMDKANILEYEKVQIVDIDNGNRFETYVIAGEKHSGVICLNGAAARMVQKGDKIIIMSYCSLTIDEANKFNPTVLFVDNKNNIEKLTNYEKHGEII
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_KINRD
Sequence: MSDLLVVPDAERVAATVVAGFRDVVDFPQPGVVFKDITPLLADARAFATVVEALAALARASGASAVAGIEARGFMLAAPAAERAGLGFWPVRKAGKLPAPVLRREYALEYGTAALELSAGTVGAGERVLVVDDVLATGGTARAACELLEEAGAQVVALAVLLELAPLGGRPRLGDRPVVALHTQT
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLTC_LISMC
Sequence: MAFRENVLEILEEITETDEVVQNTNIKLFDEGLLDSMATVQLLIEIEEKLDITVPVSEFDRDEWATPEMIITQLEALK
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCDB_NOCFA
Sequence: MLLSDRDIRAEIAAGRLGVEPLLENLIQPSSIDVRLDRMFRVFDNSRYTHIDPAQRQDELTSLVEPGEGEPFVLHPGEFVLGSTLEVCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLFRLSSPAEHPYGSAAAGSKYQGQRGPTPSRSYLNFPLPSDAVDAVESR
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: YIDD_METS4
Sequence: MSLPRRAAHAAIRAYQLTLSGLVGRQCRHWPSCSAYADEAIQRHGLWAGGWMGLARICRCGPFGTHGIDLVCEALPEGAAWHRPWAYGRWRGVNAPAPLGE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RER1_DICDI
Sequence: MPTTIDEGLPAPHNFVSFTTLIARKYQNLIEKTISFIPQRWAFVGFLSFLYILRVSLSSGGWYVITYALGIFLLTRFIAFLSPKWDPELEEDSGDSLPTTLNRNDDEAKPFIRRLPEFLFWHSIFKALFISIFCTFIPFLDLPVFWPILLLYFIIIFSVTMKKQIKHMIKYKYIPFTVGKKTYTKNNS
What is the function of this protein?
May be involved in protein transport along the secretory pathway.
What are the official names of this protein?
Protein RER1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RER1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MTNN_YERE8
Sequence: MKVGIIGAMEEEVTLLRDKIENRQTLSRAGCEIYTGQLNGIDVALLKSGIGKVSAAMGTTLLLEHCQPDIVINTGSAGGLASSLKVGDIVVSTEVRYHDADVTAFGYEPGQMAGCPAAFIADLKLIELAESCIKQLDLNAVRGLICSGDAFINGAAPLARIRTTFPSVAAVEMEAAAIGHVCYLFKTPFVVVRAISDVADQESHLSFDEFLVVAAKQSTLMIEAMLTSLAKRG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RNPA_BACCN
Sequence: MKKKNRIKKNDEFQAVFQKGRSSANRQFVIYQLDKETQPYFRIGLSVSKKIGNAVVRNRIKRMIRQSITELKDEIDSGKDFVIIARKPCAEMTYEEFKKSLIHAFKRSGIKITNK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: SURF1_ARATH
Sequence: MATSLSKILTRSNTKRYWCSTTTSISASPSLPKQFWSRHFSAVADSSSSSSAALGSQSSSSAPPQENKRGSKWSQLLLFLPGAITFGLGSWQIVRREEKFKTLEYQQQRLNMEPIKLNIDHPLDKNLNALEFRRVSCKGVFDEQRSIYLGPRSRSISGITENGFFVITPLMPIPGDLDSMQSPILVNRGWVPRSWREKSQESAEAEFIANQSTKAKSPSNEPKSWWKFWSKTPVITKEHISAVKPVEVVGVIRGGENPSIFVPSNDPSTGQWFYVDVPAMARAVGLPENTIYVEDVHEHVDRSRPYPVPKDINTLIRSKVMPQDHLNYSITWYSLSAAVTFMAYKRLKAKPVRR
What is the function of this protein?
Probably involved in the biogenesis of the COX complex.
What are the official names of this protein?
Surfeit locus protein 1, Surfeit 1, Cytochrome c oxidase assembly protein SURF1, Protein EMBRYO DEFECTIVE 3121, Surfeit locus 1 cytochrome c oxidase biogenesis protein.
What is the protein family that this protein belongs to?
Belongs to the SURF1 (TC 3.D.4.8) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL2_HAEI8
Sequence: MAIVKCKPTSAGRRHVVKIVNPELHKGKPYAPLLDTKSKTGGRNNYGRITTRHIGGGHKQHYRLIDFKRNKLDIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLSVGDQIQAGINSPIKVGNSLPMRNIPVGSTVHNVELKPGKGGQIARSAGAYVQIIAREGNYVTLRLRSGEMRKVLAECVATIGEVGNSEHMLRVLGKAGANRWRGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRHNKRTDKYIVRRRGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PSBD_ORYSI
Sequence: MTIALGRVTKEENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAISFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YNDH_RHOCA
Sequence: MKDPNRPTLSVTLDGREVKLVPVIIEGYRLEVEGKNVTSFLSKTPPIMRAVGALEGRGDFGVGDLEVASDTRKWTVSGPVKQDTGKTDPAEKN
What are the official names of this protein?
Uncharacterized 10.1 kDa protein in ndhA-ndhI intergenic region.
Protein: PSBD_CUSSA
Sequence: MTITLGQSTKNDKDLFDTMDDWLRRDRFLFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCKLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFFIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVSGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQSEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRASEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid membrane; Multi-pass membrane protein.
Protein: ADH1E_HORSE
Sequence: MSTAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF
What are the official names of this protein?
Alcohol dehydrogenase E chain.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_LIMF3
Sequence: MKQALTPEQIKEQKPYLDWSLSEREYDYISEKLLGRLPNFTETGLFSAMWSEHCSYKKSKPVLRLFPNQNDRVLQGPGEGAGVVDIDDGQAVVFKAESHNHPSTVEPYQGAATGVGGILRDIFSMGARPIASLDSLHFGELDDPKMQMKVAGTVKGIGDYGNCMGIPTVAGETTFDPCYSGNLLVNAMSVGLMDQKDIQKGKAAGIGNAVMYVGAKTGRDGIHGATFASADFSDENATQRSAVQVGDPFMEKLLLEACLELIQNHPDWLVGIQDMGAAGIVSSSAEMASEGDAGMDLDLDLVPQREPNMSAYEIMLSESQERMLLCVNKGHEDDVKKIFDFYGLEAVTIGRITEGRQYVLHHDGQVVCDIPVSSLTDDVLEETSEEQKPARILQAEQEANWQPEVTDAGATLEQLLQQSTIADKSIFFEQYDSMVRTSTVVGPGSDAGVLRVRGTKKGLAMTTDGNGRFVYLNPEVGGKMALAEAAANIVATGALPLAITDCLNYGDPNDPEIFWELHQSVSGMAEACRVFDTPVISGNVSLYNENNGQAIHPTPMVGMVGLIKDLKNLVKMAAQAAGDQVYLLGQTGDDYAGSELQKMLTGDIAGTVADFDLNHVHAMMKTLLSLMEDGKVASAHDLAEGGLGVALAETLFKTDLGMNLKLDLTKNQLFSETAGRFVVTVKKEDAAAFEAALGDDATLIGEVTNSHWLQVRLADGNLNKNVADLEQLWKEAIPCQLKSRD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDH_STRCO
Sequence: MTDVNGAPADVLHTLFHSDQGGHEQVVLCQDRASGLKAVIALHSTALGPALGGTRFYPYASEAEAVADALNLARGMSYKNAMAGLDHGGGKAVIIGDPEQIKSEELLLAYGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTSFGVYQGMRAAAQHLWGDPTLRDRTVGIAGVGKVGHHLVEHLLAEGAHVVVTDVRKDVVRGITERHPSVVAVADTDALIRVENLDIYAPCALGGALNDDTVPVLTAKVVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKAKASKIYDTTLAIFARAKEDGIPPAAAADRIAEQRMAEARPRP
What is the function of this protein?
Oxidative deamination of branched-chain amino acids.  Oxidizes L-valine and L-alpha-aminobutyric acid efficiently, and L-isoleucine and L-leucine less efficiently.  Does not act on D-valine.  The catabolism of L-valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors.  Uses NAD; no activity was found with NADP.
What are the official names of this protein?
Valine dehydrogenase, ValDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_YERPG
Sequence: MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLVIIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLTSANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYMLLSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVSTFLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHELALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVVAMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLVQMAQPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPPH_HYDCU
Sequence: MIDADGYRPNVGIIIVNKEGKLFWGKRLYQDAWQFPQGGVRENETPQQAVFRELKEEVGLEPSDVRVLGRTKDWLTYDLPKHLIRHYSQPVCIGQKQIWFLLGMLSDDEKINLNTHETPEFEGWSWVDYWVPVQNVVEFKQSVYHQALTELETHLHKFWTKEHVG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: LY9_MOUSE
Sequence: MADLKRYWCDWALGPLSENPRMSQQQIFSPILWIPLLFLLMGLGASGKETPPTVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYKKDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSYHAQINQKNVILTTNKEFTLHIYEKLQKPQIIVESVTPSDTDSCTFTLICTVKGTKDSVQYSWTREDTHLNTYDGSHTLRVSQSVCDPDLPYTCKAWNPVSQNSSQPVRIWQFCTGASRRKTAAGKTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERRGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGPYHAYVCSEASRDPSVRHFTLLVYKRLEKPSVTKSPVHMMNGICEVVLTCSVDGGGNNVTYTWMPLQNKAVMSQGKSHLNVSWESGEHLPNFTCTAHNPVSNSSSQFSSGTICSGPERNKRFWLLLLLVLLLLMLIGGYFILRKKKQCSSLATRYRQAEVPAEIPETPTGHGQFSVLSQRYEKLDMSAKTTRHQPTPTSDTSSESSATTEEDDEKTRMHSTANSRNQVYDLVTHQDIAHALAYEGQVEYEAITPYDKVDGSMDEEDMAYIQVSLNVQGETPLPQKKEDSNTIYCSVQKPKKTAQTPQQDAESPETPTYENFT
What is the function of this protein?
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.  SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.  Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922).  May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.  Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A.  Promotes recruitment of RORC to the IL-17 promoter (By similarity).  May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response.  May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells (PubMed:23914190).  May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888).  Can promote natural killer (NK) cell activation (PubMed:19648922).
What are the official names of this protein?
T-lymphocyte surface antigen Ly-9, Cell surface molecule Ly-9, Lymphocyte antigen 9, SLAM family member 3, SLAMF3, Signaling lymphocytic activation molecule 3.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell membrane.