PharMolix/UniProtQA huggingface dataset:
Protein: TNR3_MOUSE
Sequence: MRLPRASSPCGLAWGPLLLGLSGLLVASQPQLVPPYRIENQTCWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCRPCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTDEIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEPGAMLLLAILLSLVLFLLFTTVLACAWMRHPSLCRKLGTLLKRHPEGEESPPCPAPRADPHFPDLAEPLLPMSGDLSPSPAGPPTAPSLEEVVLQQQSPLVQARELEAEPGEHGQVAHGANGIHVTGGSVTVTGNIYIYNGPVLGGTRGPGDPPAPPEPPYPTPEEGAPGPSELSTPYQEDGKAWHLAETETLGCQDL
What is the function of this protein?
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT.  Promotes apoptosis via TRAF3 and TRAF5.  May play a role in the development of lymphoid organs (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DXR_NITEU
Sequence: MTKTRHLTILGSTGSIGESTLDVVARHPGRYQVVALTADRNVEKMFEQCIQFHPPYAVMLDAQSAEQLEDRLHAAGLDTRVLSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLAAARTGKHILLANKETLVMAGRVFMDTLRQHHATLLPIDSEHNAIFQSLPQHFNGDLAGSGVRRILLTASGGPFRTVDLKILETVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNAVPEKIQVVIHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALSYPERMESGVQSLDMFKVARLDFESPDFKRFPCLRLAYEALAAGGNMPAVLNAANEVAVEVFLAGRIPFTAIPVMIEDVMKSTERRDVPDLEGVLLADLQARATAREWLACNIRQSTGQPGKPASSLSAGQ
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: LEUD_SULIK
Sequence: MIIEGPVIKFGDKIDTDIIIPARYLKYTDPQYLAQHAMEPLDPEFYKKASKGVIIVAGKVFGMGSSREQAAIALKAAGVKAVVAESFARIFYRNAINNGLPVITLPNSTKEIDENSYVKIDVETGEILVGNKVLKGKGITGMALEILQAGGIMEYLKKMQTVNRN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: FTSQ_BARBA
Sequence: MDSGGRIVYALNVEKTGFLRILSVTVLQRLYRRVFWFLFKCVAGIDVPRHAGSLAVFSFFFLSILYSISSGGYMNHFMKVAISNSGFLVTHVDMSGNKRMMEQDILKVLGLDEYPSMISFDIDKARFILEQQPWVRLADVQKIYPDRLRISLVEREPYAIWQHNGEMNIIDDTGYVIAPFQAGLVQNLSFVVGQGAQKTAKLFIQALSVYPQLQNHVRAYVRVGDRRWDLFLANGMRIMLPENGAIERLASFIEQGVAEDLFSRDISDIDLRLSDRITVSLSDEALTRRRAVVLEEERLLKMLKAGSV
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: EFP_CUPMC
Sequence: MKIAQELRVGNVFMIGSDPMVVQKAEYNKSGRNAAVVKMKYKNLLTEAPGESVFKADDKFEVVVLERRECTYSYFADPMYVFMDTEYNQYEVEKDSMGDSLNYLEDGMVVEVVFYNDKAISVEMPTTLVREIIYTEPAVKGDTSSGKVLKGAKINTGFELQVPLFCNIGDKIEIDTRTGEYRSRAN
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC3_SCHCO
Sequence: MFARLPVVFLYAFVAFGALVAALPGGHPGTTTPPVTTTVTVTTPPSTTTIAAGGTCTTGSLSCCNQVQSASSSPVTALLGLLGIVLSDLNVLVGISCSPLTVIGVGGSGCSAQTVCCENTQFNGLINIGCTPINIL
What is the function of this protein?
Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures.
What are the official names of this protein?
Fruiting body protein SC3, Hydrophobin SC3.
What is the protein family that this protein belongs to?
Belongs to the fungal hydrophobin family.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted. Note=Cell wall of aerial hyphae. Abundantly secreted from the tips of submerged hyphae.
Protein: DBH2_STRLI
Sequence: MNKAQLVEAIADKLGGRQQAADAVDAVLDALVRAVVAGDRVSVTGFGSFEKVDRPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVSGSKKLPKNDIAVKKAPKGSLSGPPPTISKAAGKKAAAKKATGAAKKTTGAAKKTSAAAKKTTAKKTTGAAKTTAKKTTAKKSAAKTTTAAAKKTAAKKAPAKKATAKKAPAKKSTARKTTAKKATARKK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL4_GEODF
Sequence: MAKLDVYNTSHKKVGEIELSDAVFNDEVREYLIHEAVKIQLANRRAGTVAVKNRAAVSGSGKKPFKQKGTGQARQGCKRAPQYPGGGVAFGPQPKTYNLSMNKKARRAALRSALSLLFKNDKLTVLDAINLDTVSTKNFVGVLKGFSLDKALVVTDAENRNLELSARNIKNVKVLKTEGLNIFDLMKYQRVIFTENSVRKVEGALQS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TAM41_SCHPO
Sequence: MIFGKTHFLSYNILRYSTKRWMNRHSYSHHAKCTVAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPIDVAVGYGSGVFRQAGYSQKENPMIDFIFQVEDPVKWHKINLQQNPSHYSFVKNFGPGFVSTLQESFGTGVYYNTHVEVEGNIIKYGVTSKKDVYEDLKNWNTMYLAGRFQKPVVILKGEDEFYKENSYNLSSALHVGLLMLADRFTEFDLYKTIVSLSYLGDIRMSFFAENPRKVENIVSKQIAFFRKLYLPLLYAEPGVHFIESSEVLKSMDPSDNSRYLSFHQNITKDSISRLLNGLPLNLVKILGLKPDTSSFEKCAELMLTNQISTRSLLISKSIKKLTSFSILTQSIKGIFTAGVIRSFVYVYAKLKKGLLSKWGR
What is the function of this protein?
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane.  Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
What are the official names of this protein?
Phosphatidate cytidylyltransferase, mitochondrial, CDP-diacylglycerol synthase, CDP-DAG synthase, Mitochondrial translocator assembly and maintenance protein 41 homolog, TAM41.
What is the protein family that this protein belongs to?
Belongs to the TAM41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CHMP7_DANRE
Sequence: MSVSVEKRSAWFPPDWDDDERMSFLFSAFKENRDVDCTDWDGKIDFWSPLIIEHCRRCGSVCVNLQDLNENFRRKGSVPLGLSTVIQSMIRSGKVQKESDFAANVDSGWLSWGVGLLLVRPLKWTLSALLGSGRVPLEESFVVIELVKEKAAELLAAYRGSALSARSLLSFQELRSLSSHICPDESTLCMALLQLQREKHVTVSLHEGEKLVKFSQAGQGRVSPVSEVDLGIYQLQCSEKLLEERVEALGHEAEKCKQQAKSLLKEGKKSQALRCLRGSKRVEKKADRLFAQLETVKGILDRIANSQTDRLVMQAYQAGVAALRISLKGVTVERAENLVDQIQELCDTQDEVNQTLASGAPDAGEDSEDLEEELKSLMEKSVPENDLFPAVPTHPITPPRKTDLPDAAFVQFLPSVPNPGMNITDEELDRELRRLTVSDKGLPRESVSPQRRLEPAQ
What is the function of this protein?
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase.  Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase.  Plays a role in the endosomal sorting pathway.
What are the official names of this protein?
Charged multivesicular body protein 7, Chromatin-modifying protein 7.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the nucleus envelope during late anaphase.
Protein: TOLB_HISS2
Sequence: MKFSAYLTTLFIVLFSLFIQTVQAESEVRIVIDEGVDSARPIAIIPFKWNGSDSMPIDVADIISADLRNSGKFNPIAVSKMPQKPTSASEVISDVWSSLGIDAVVVGQVTPNEKGYSIAYQLVDTIGASGNSGEVLSQNQYAVPKNAIRLGAHTISDEVFEKLTAIRGAFRTKIAYVVQKNGGSKPYQVRIADYDGHNQFIVYSSSQPLMSPAWSPDGSKLAYVSFENRKSQLIVHDLQSGARRVIAAFPGHNGAPAFSPDGSKIAFASSKDGVLNIYVMNLGNGTISQLTSGAGNNTEPSWSPDGQSIIFTSDRAGGPQIYQMDVVGNGVSLVSAGRGYSGKISADGSILVMIYGDNIVKKDLATGVTEMLSSTFLDESPSISPNGIMIIYSSTQGLGKVLQLVSADGRFKARLPSSDGQIKFPAWSPYLNKN
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RNPH_FRATN
Sequence: MRPSGRNNDQLRNLKVTHNFTKHAEGSVLIEFGDTKVICTASVVAGVPEFKKDSGEGWLTAEYGMLPRSTHTRMDREAARGKQSGRTQEIQRLIGRALRASVDLTAIGENTIKVDCDVIQADGGTRTASITGASLAIADAIEYMKQNGMLDEQANPLLSQVAAISVGIYNNEPVLDLDYDEDSNAETDMNVVMNSNGGIIEIQGTAEGKDFSEEEFAKMLGLAKKGIKEIFATVF
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: MPAA_ECO57
Sequence: MTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPAASRESGLILAGTHGDENSSVVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTSVGYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKDAIRPS
What is the function of this protein?
Involved in muropeptide degradation.  Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.
What are the official names of this protein?
Murein peptide amidase A, Gamma-D-Glu-Dap amidase, Zinc metallocarboxypeptidase MpaA.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_KLEP3
Sequence: MSTDNKQSLPALTLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFTVSIKYITFVMRADNAGEGGILTLMSLAGRNTSARMTSVLVILGLIGGSFFYGEVVITPAISVMSAIEGLEIIAPQLDTWIVPISIIVLTLLFVIQKHGTGMVGKLFAPIMLIWFLLLAVLGARSILDNPEVLQALNPYWAVHFFLQYKTVSFIALGAVVLSITGVEALYADMGHFGKLPIRVAWFSVVLPSLVLNYFGQGALLLKHPEAIKNPFFLLAPEWALIPMLIIATLATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFINWLLYVSVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSATVARKNWHWNKLFVGLMLVAFLCIDIPLFSANLDKIVSGGWLPLSLGLVMFTVMTTWKSERFRLLRRMHEHGNSLEAMISSLEKSPPVRVPGTAVYMSRALNVIPFALLHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPSFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLIIGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WETA_EMENI
Sequence: MFAHPFDHSFNDLFNQYVNMDTSSTDANKDVSFPSEFDQLFPLDSFSTDCGDQSPVISTVQHNSQPAQDWGKDLWSLSQNTGCSTNQDSFSFQDSTQPSTALDLSIGLEADATGHSQASVPRSTPSTPPATPGPKVKGGLFTPKTIRHHRESNDRRGLLRKQSFSPGLMRSSQLQKGSCRMAYPEAWAQRLQNFTIRSSDECLPLSPPPSDILVQQENVKHTPVQMRNAAEGFQGSTELPQQIDSGYITQSPAIPMPSPSANALAGQQQRYLSQTGTSALTPSPPSARDVFSSPHSSDPQSMPSWHSESLNTPAFQYTPELSDHQTWWSPMPSEVAQRHASYQQMIASPAPQRPVQAAANHGDFLQGGLMIQLDPTQFDISSSFPSSTIPTTANNHDNLAYNVEAHAPQKYVDASSFNTQAVPHPSRSPSISPKADTSPRHGSANRDGMAMKNAPRRPHGRKLSGQSTSTPKPVKTPNSLSTSPRGGKSVTVSFVNFTANDRQKILTGVAPSGSSKTKARREQEARDRRRKLSEAALQAVRKAGGDVEALEAVLC
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation.  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (PubMed:2655931).  Responsible for activating a set of genes whose products make up the final two conidial wall layers or direct their assembly and, through this activity, is responsible for acquisition of spore dormancy (PubMed:1986246, PubMed:2180753, PubMed:7704830).
What are the official names of this protein?
Developmental regulatory protein wetA.
What is the protein family that this protein belongs to?
Belongs to the wetA family.
Protein: ISPD_ECOK1
Sequence: MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPRITVVDGGEERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RL29_SALTI
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SYL_STAAC
Sequence: MLNYNHNQIEKKWQDYWDENKTFKTNDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTKKNIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVYRKPMKQWVLKITEYADQLLADLDDLDWPESLKDMQRNWIGRSEGAKVSFDVDNTEGKVEVFTTRPDTIYGASFLVLSPEHALVNSITTDEYKEKVKAYQTEASKKSDLERTDLAKDKSGVFTGAYATNPLSGEKVQIWIADYVLSTYGTGAIMAVPAHDDRDYEFAKKFDLPIIEVIEGGNVEEAAYTGEGKHINSGELDGLENEAAITKAIQLLEQKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLLLPETDEIKPSGTGESPLANIDSFVNVVDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPKNENMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLYDLAIVPTKEPFQKLFNQGMILGEGNEKMSKSKGNVINPDDIVQSHGADTLRLYEMFMGPLDAAIAWSEKGLDGSRRFLDRVWRLMVNEDGTLSSKIVTTNNKSLDKVYNQTVKKVTEDFETLGFNTAISQLMVFINECYKVDEVYKPYIEGFVKMLAPIAPHIGEELWSKLGHEESITYQPWPTYDEALLVDDEVEIVVQVNGKLRAKIKIAKDTSKEEMQEIALSNDNVKASIEGKDIMKVIAVPQKLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADM1_MOUSE
Sequence: MASAVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
What is the function of this protein?
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663).  Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (PubMed:12826663).  Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).  In mast cells, may mediate attachment to and promote communication with nerves (By similarity).  CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125).  By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223).  Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959).  Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959).  Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303).  May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673).  May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000).
What are the official names of this protein?
Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumor suppressor in lung cancer 1, TSLC-1.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Synaptic cell membrane; Single-pass type I membrane protein. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
Protein: CYB_ONCKE
Sequence: MANLRKTHPLLKIANDALVDLPAPSNISVWWNFGSLLGLCLATQILTGLFLAMHYTSDISTAFSSVCHICRDVSYGWLIRNIHANGASFFFICIYMHIARGLYYGSYLYKETWNIGVVLLLLTMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVGGALVQWIWGGFSVDNATLTRFFAFHFLFPFVIAAATVLHLLFLHETGSNNPAGINSDADKISFHPYFSYKDLLGFVAMLLGLTSLALFAPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILVLMVVPILHTSKQRGLTFRPLTQFLFWALVADMLILTWIGGMPVEHPFIIIGQIASVIYFTIFLVLSPLAGWAENKALQWA
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DBP2_KLULA
Sequence: MSFGGGRDHQFNRNNMGSTHGDFRGSRGSDRNSYNRGNDFRGGRSFGRGPSRDTRVDLVAPNWDEELPNLPVFEKNFYQEHPDVAQMSESEVIEFRKENEMTISGHDVPKPIRSFDEAGFPSYVLDEVKQEGFAKPTGIQCQGWPMALSGRDMIGVAATGSGKTLSYCLPGIVHINAQPLLSPGDGPIVLVLAPTRELAVQIQKECSKFGASSRIRNTCVYGGVPKSQQIRDLQRGVEILIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVKQLASDYLHDPIQVQIGSLELSASHTITQIVEVLTDFEKRDRLAKHLETASQDQDSKIIIFASTKRTCDEITSYLRTEGWPALAIHGDKAQNERDWVLAEFRSGRSPIMVATDVAARGIDVKGINYVINYDMPGNIEDYVHRIGRTGRAGSTGTAISFFTEGNKSLGAALIKIMREAKQDIPEELRRYDRGQYGQHPRYGGGRGGRGFGGGRGGRGFGGRGDGGYGGGGYGGGRGGFGGNRSRDQGWRR
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RHOF_HUMAN
Sequence: MDAPGALAQTAAPGPGRKELKIVIVGDGGCGKTSLLMVYSQGSFPEHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMNPTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFRENVEDVFREAAKVALSALKKAQRQKKRRLCLLL
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.  Causes the formation of thin, actin-rich surface projections called filopodia.  Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
What are the official names of this protein?
Rho-related GTP-binding protein RhoF, Rho family GTPase Rif, Rho in filopodia.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein: SPRTL_BACCN
Sequence: MNDKEIQRLVEEISLRYFEMPFLHRATFNMRLRTTGGRYVLKSHNIELNYHYYKLYGREELIGIIKHELCHYHLHIEGKGYQHRDRDFRQLLEKVDAPRFCKRMPVSNKGERTYVYECVECSFQYVRRRQMNIRKYVCGRCKGKVKQIEKRLDS
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_XANC8
Sequence: MTTFTAKSETVQRDWYLVDAAGKTLGRLSTELARRLRGKHKPVYTPHVDTGDYLVVINAEKIVVTGNKLKDKKYHRFTGYIGNLKTESLEQALQRHPERVIEIAVKGMLPKGPLGRTMYRKLKVYSGAEHPHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ASAA_ASPFN
Sequence: MGAPHEEIQALKRRREQNRLAQRRRRDNVRRRLRDLGLDTGSPASASQTSLCSSTDSRVTLNPHQSLRSTDFLSFETSNSDTEMSPYDPPLQSKLRLDSQIPLAEISFPSYASSVSPSSSAGPLSSSPSPSQRPFIDSTDLTSLQSVYNPTSLAVHLDESSMPCGEAEIPTRQDSNFPRTPNLKSLMSGCNDPSAYQPWILTSSTVGEQMSSQALPHSPGPQHCSTPLPAETRPRWTTALHMAVSQGNFSVMRLLLSYGADPNAVNSEGATALHVGVMNGNYTMVAELLQRGADPTLTNAAGWLPLHQAVHAGDEGCVRVLLEADQPVDYPISDLDYT
What is the function of this protein?
Transcription coregulator involved in regulation of gene cluster that mediates the biosynthesis of aspergillic acid, a hydroxamic acid-containing pyrazinone with aliphatic side chains that originates from leucine (Leu) and isoleucine (Ile) (PubMed:29674152).  Aspergillic acid has antibiotic properties and was shown to be lethal to mice (PubMed:29674152).
What are the official names of this protein?
Ankyrin-repeat domain containing transcription coregulator asaA, Aspergillic acid biosynthesis cluster protein A.