PharMolix/UniProtQA huggingface dataset:
Protein: OPGB_SALAR
Sequence: MSELLSVALFLASVLVYAWKAGRNTWWFAATLTVLGLFVILNITRYASDYFTGDGINDAVLYTLTNSLTGAGVGKYILPGIGIVLALVGVFGALGWILRRRRHHPHHVGYSLLALLLALGSVDASPAFRQITELVKSQTRDGDPDFAVYYKEPAKTIPNPKLNLVYIYGESLERTYFDNDAFPNLTPELGALKNEGLDFSHTMQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNAGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGAEELKTVVTDPSYRNDWGFYDDTVLDEAWKKFEALSRSGQRFSLFTLTVDTHHPDGFISRTCNRKRYDYDSKPNQSFSAVSCSQENIARFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFILRGDKPQQETLAVKRNTMDNGATVLDILGGDNFIGLGRSSLSGQSLSEVFLNVKEKVLAMKPDIVRLWNFPKEMKAFTIDQDKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWVDRCYKMAQLWAPELALSTDWCVSQGQLGGQQTVQHVDKTQWKGKTAFKDTVIDMQRYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPETWGRWSNAQLGDEVKIEYKAPLPKKFDLVITAKAFGDNANRPIPVRVGNEEQTLVLGHDVSTTTLHFNNPTDASTLVIAPPVPVSTNEGNILGHSPRKLGIGMVEIKVVNAES
What is the function of this protein?
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
What are the official names of this protein?
Phosphoglycerol transferase I, Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the OpgB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DHX15_DICDI
Sequence: MSKRKHESSDSNKKAMKKQQNKIEEEEEEITNTTTTTTTTNNNYNNIKSNLTIDQWIPKKETFSKRYYEILEKRKELPVWKQKEDFIKVIKENQVVILVGETGSGKTTQIPQFVVDAGLIRPGKMVGVTQPRRVAAISVAKRVSEEMDFELGEEVGYSIRFEELSSARTFMKYLTDGMLLRESMSDPTLNKYDVIILDEAHERTLSTDILFGLIKDILKRRKDLKLIVMSATLEAGKFQKYFENAPLIKVPGRLHPVEIFYTEEAAKDYLESAVRTVIDIHTNEGTGDILVFLTGEEEIEDTCAKIQRETRERGLPPMKTLPLYSSLPIYQQSKIFDTCKERKCIVSTNIAETSLTIDGIVFVVDPGFSKQKTYNPRSRVESLLVAPISKASANQRAGRAGRTRPGKCFRLYTEKAFKELMIQQTHPEILRSNLASVVLQLLKLGVVDLVHFDFMDPPVPDTLIRALEVLHYLGALDDEGQLTEIGSIMSEFPLDPQLSKMLIVSAERSCSNEILTIAAMLSAPNCFMRPKDNRIEADSAKKSFDHFDGDHLTMLNVYHSFKKNGEDPTWCYDNFLNHRAIKQADSVRSQLARILTRFKLPLVSGDVNSKFYYENIKKCIAAGFFMQVAKCEKKNIYFTLGDEQSVIFHPSTGLTRRPEFCIYNEFVLTSENYIRTITDVKFDWLLELAPSYFKQKSFPKKTKETIQRAQRLYSGSSSGSSSGSNKK
What is the function of this protein?
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
What are the official names of this protein?
Putative ATP-dependent RNA helicase DHX15, DEAH box protein 15.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXC_FRATT
Sequence: MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEAIMCTLLTKDGDQNLSVSTIEHLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQVGIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFKIHWDHPVIAATNDHIVFEYDLDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRHKLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: TPIS_MYCSS
Sequence: MARKPLIAGNWKMNLNHFEAIALVQKIAFSLPDKYFDKVDVTVIPPFTDLRSVQTLVDGDKLRLSYGAQDVSQHDSGAYTGEISGAFLAKLGCSFAVVGHSERRTYHHEDDALVAAKAAAAFRHGITPIVCIGEHLKVREAGNHVEHNVEQLRGSLAGLTSEQIGQAVIAYEPVWAIGTGRVAGAADAQEVCKAIRDELGKLSSPQLAAGIRVLYGGSVNAKNVGEIVAQEDVDGALVGGASLDGEQFATLSAIAAGGPLP
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_CAMC5
Sequence: MSSYLDFEKSIKQIDDDIANARIKGDEHAVEILNKNLEKEVAKVYKNLNEYQRLQLARHPDRPYAIDYIRSFLMDAYEIHGDRAFRDDPAIVCYVGYIGGKKAMVIGEQKGRGTKNKLRRNFGMPHPEGYRKALRVAKLAEKFNLPILFLIDTPGAYPGVGAEERGQSEAIARNLFEFANLKVPTIAVVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAILWNDPSKQEQATKAMKITADDLKNLKLIDDVIKEPINGAHRDKDGAAKELASYFVSKLEKLEKLSIDELVAKRIDKILSVGAYEE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRDD_MANSM
Sequence: MVDQNPKRSNEPPVWLMFSAGGMVSGLAFPVLILILGILLPFGIISPDNIIAFSHHWFGKLVILALTIFPMWAGLHRLHHGMHDIKVHVPNGGLIFYGLAAVYSFIVLFAVIAI
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1829_STAAW
Sequence: MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
What are the official names of this protein?
UPF0421 protein MW1829.
What is the protein family that this protein belongs to?
Belongs to the UPF0421 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y502_MYCTO
Sequence: MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPNDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRETIQQTLYRLLAGRRNIFFG
What are the official names of this protein?
Uncharacterized protein MT0523.
What is the protein family that this protein belongs to?
To M.leprae ML2427.
Protein: COPA_STAA3
Sequence: MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAKEKQLILTETTTFKAVPGHGIEATIDHHYILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA
What is the function of this protein?
Involved in copper export.
What are the official names of this protein?
Copper-exporting P-type ATPase, Copper-exporting P-type ATPase A, Cu(+)-exporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UXUA_SALHS
Sequence: MKQTWRWYGPNDPVTLSDVRQAGATGVVTALHHIPNGEIWSVDEIQKRKAIVEEAGLEWSVVESVPIHEDIKTHTGQYDLWIKNYQQTLRNLAQCGIYTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFELHILKRPGAEADYTAEEIAQAERRFATMSEEDKARLTRNIIAGLPGAEEGYTLDQFRQHLATYKDIDKAKLREHFAYFLKAIIPVADEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVETVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTLREENPKTFHEAAHLHGDVDMYEVVKAIVEEEHRRKAEGSDDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: QORH_ARATH
Sequence: MAGKLMHALQYNSYGGGAAGLEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMIRPFLPRKFPCIPATDVAGEVVEVGSGVKNFKAGDKVVAVLSHLGGGGLAEFAVATEKLTVKRPQEVGAAEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGVGHYAVQLAKLANAHVTATCGARNIEFVKSLGADEVLDYKTPEGAALKSPSGKKYDAVVHCANGIPFSVFEPNLSENGKVIDITPGPNAMWTYAVKKITMSKKQLVPLLLIPKAENLEFMVNLVKEGKVKTVIDSKHPLSKAEDAWAKSIDGHATGKIIVEP
What is the function of this protein?
NADPH-dependent alpha,beta-unsaturated oxoene reductase reducing the double bond of medium-chain (C9) to long-chain (C18) reactive electrophile species deriving from poly-unsaturated fatty acid peroxides.  The best substrates are 13-lipoxygenase-derived gamma-ketols, but is unable to reduce the double bond of short-chain alkenals and alkenones such as acrolein, crotonaldehyde, 3-buten-2-one, 4-hexen-3-one and trans-2-hexenal, or quinones such as duroquinone, decylubiquinone, coenzyme Q0, menadione, menaquinone and phylloquinone.  Can use trans-2-nonenal, trans-3-decen-2-one, 4-hydroxynonenal, 12-oxo-10(E) dodecanoate (traumatin), 4-oxononenal, trans-1,3 diphenyl-2-propenone, trans-1,4-diphenyl-2-butene-1,4-dione, 9-oxo-12,13-epoxy-(10E)-octadecenoic acid (trans-EKODE-1b), 9-hydroxy-12-oxo-10(E)-octadecenoic acid, 9-Hydroxy-12-oxo-10(E),15(Z)-octadecadienoic acid and 9,13-dihydroxy-10-oxo-11-octadecenoic acid as substrates, but has no activity with 13(R,S)-hydroperoxy-9(Z),11(E)-octadecadienoic acid (13-HPOD), 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acid, 13-hydroxy-12-oxo-9(Z)-octadecenoic acid, 9-oxo-10(E),12(Z)-octadecadienoic acid (9-KODE), 13-oxo-9(Z),11(E)-octadecadienoic acid (13-KODE) and 12-oxo-10,15(Z)-phytodienoic acid (12-OPDA).
What are the official names of this protein?
Chloroplast envelope quinone oxidoreductase homolog, ceQORH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane. Note=Faces the stroma side of the membrane (PubMed:20424175). Targeting to the chloroplast inner membrane is mediated by HP30-1, HP30-2 and HP20 (PubMed:24248378).
Protein: PLI2C_ARATH
Sequence: MAAFTGTTDKCKACDKTVYVMDLMTLEGMPYHKSCFRCSHCNGTLVICNYSSMDGVLYCKTHFEQLFKESGNFSKNFQTAGKTEKSNDATKAPNRLSSFFSGTQDKCAACKKTVYPLEKMTMEGESYHKTCFRCAHSGCPLTHSSYAALDGVLYCKVHFSQLFLEKGNYNHVLQAAANHRRSTAEEDKTEPKEDEANPTEEETSDAAAEEHES
What is the function of this protein?
Binds to actin filaments and promotes cross-linking into thick bundles.  Has an actin-stabilizing activity.  Associates predominantly with long and dynamic actin bundles in the shank of growing pollen tubes.  The actin regulatory activities are inhibited by pH > 6. 8 and/or high [Ca(2+)].
What are the official names of this protein?
LIM domain-containing protein PLIM2c, Pollen-expressed LIM protein 2C.
Protein: Y1159_BACCR
Sequence: MAKDSSFDIVSKVELPEVTNAINIALKEIQNRYDFKGSKSDIKLEKEVLVLTSDDEFKLEQVKDVLISKLVKRNVPIKNLDYGKVEAATGNTVRQRATLQQGIDKDNAKKINNIIKEMKLKVKTQVQDDQVRVTAKSRDDLQAVIAAVRSADLPIDVQFINYR
What are the official names of this protein?
UPF0234 protein BC_1159.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: Y4GA_SINFN
Sequence: MCQWAATKGTRNHAYEREKLERAFAKILRHRDPSVPPRRSDPRPRKEVARQWRKPHIYSPADLRRMLDIARSYPSPRAALRQENMYTMLLLAYCAGLRRGELARLDLGDVNLGDGTITVRQTKFFKTRILPLPDSVVVSFGPISLHGVGSAHSRLLTPPCSGTNKAVPAPRQEGSPGCLQTSYVVPG
What are the official names of this protein?
Uncharacterized protein y4gA.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: RS7_ENT38
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAEAIVYSALETLAQRSDKNALEAFEVALDNVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAADNKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y3428_CAUVN
Sequence: MADDAIPHTDVLNSTAQGQLKSIIERVERLEVEKAEIMEQIKEVYAEAKGNGFDVKVLKKVVRIRKQDRAKRQEEDAILDLYLSAIGEI
What are the official names of this protein?
UPF0335 protein CCNA_03428.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: DDL_BORPD
Sequence: MNQSVTRPRPDAKALGKVGVLYGGRSAERDVSLMSGKGVHQALLSAGVDAHLFDTGERTLAELAAAGFDRVFIALHGRYGEDGTLQGALELLGLPYTGSGPMASSLSMDKIMTKRVWLQHGLRTPAFEVLDAQAELRTVPDRLGLPLILKPPHEGSTVGITKVAGYSDMKEGYAQAAKFDDEVLAEQFIAGRELTVAVLGTGAAAHALPVIEIVAPGGNYDYEHKYFSDETQYFCPADLPDAVAAEVADLAVRAYRALGCAGWGRIDFMLDADNRPWLLEANTSPGMTSHSLVPMAAKAIGMSYAELCVSIVSEAACKVHSPARNS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSRP_ESCF3
Sequence: MDSAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLTPGNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTINPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLNRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: PLS31_PHYTB
Sequence: FFSMIPKIATGIASLVKNL
What is the function of this protein?
The non-amidated Phylloseptin-3. 3TR has weak antimicrobial activity against fungus C. albicans ATCC 24433 (MIC=100 uM).  Not active against Gram-negative bacterium E. coli ATCC 25922 and Gram-positive bacterium S. epidermidis ATCC 12228 at concentrations up to 100 uM (PubMed:29980138).  Has an anti-inflammatory effect, since it inhibits the production of the pro-inflammatory cytokines TNF-alpha and IL-1 beta, and induces the production of the anti-inflammatory cytokine IL-10 (PubMed:30734396).  Has high activity of stimulation of insulin release, which may protect the species from being eaten by predators by causing fatal hypoglycemia (PubMed:30734396).  Is not cytotoxic to cancer line cells (PubMed:30734396).  Shows very low hemolysis on mouse erythrocytes (LC(50)=340 uM) (PubMed:30734396).
What are the official names of this protein?
Phylloseptin-3.1TR, PLS-3.1TR, Phylloseptin-3.3TR.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MMAA_HUMAN
Sequence: MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDGLKRKLCVQTTLKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQVLLQKVLLYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGAGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAVTKSDGDLIVPARRIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLMLASGELTAKRRKQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD
What is the function of this protein?
GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572, PubMed:21138732, PubMed:28943303).  Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:28497574, PubMed:20876572).  Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:28497574, PubMed:20876572).  Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303).  Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303).  Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303).
What are the official names of this protein?
Methylmalonic aciduria type A protein, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: APOE_DICBM
Sequence: MKVLWAALVVTLLAGCGADVEPGPEVQPGPEVQLGKEWATWQASQPWEQALGRFWNYLRWVQTLSEKVQEQLLSSQVTEELTALMDDTMKEVKACKSELEEQLGPVTEETKARVSKELQAAQARLGADMEEVRSRLAQYRGELQAMVGQSTEELRGRLSAHLRKLRKRLLRDAEDLQRRLAVYQAGIREGAARSVNTLREHLGPLAEQAATVHTLVSKPLQERAEAWAQRLRGRLEKAGFPVGDRLDEVREQVQEVRAKVEEQANQVRLQAEAFQGRLKSWFEPLVQDMQQKWAELVEKVQLAVGAVPTSVPSEKQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: ACHA7_RAT
Sequence: MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  The channel is blocked by alpha-bungarotoxin.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-7.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=RIC3 promotes its trafficking to the cell membrane (PubMed:15927954). TMEM35A/NACHO promotes its trafficking to the cell membrane (By similarity).
Protein: RHMA_SALSV
Sequence: MNALLSNPFKEGLRKGDTQIGLWLSSTTSYMAEIAATSGYDWLLIDGEHAPNTVQDLYHQLQAIAPYASQPVIRPIEGSKALIKQVLDIGAQTLLIPMVDTAEQARQVVSATRYPPLGQRGVGASVARAARWGRIDNYMAQANESLCLLVQVESKVALENLDAILEVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIEACIYRIRAAGKAAGFLAVDPAMAQKCLAWGANFVAVGVDTMLYTEALDSRLAMFKSVQSVSTAKRSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: CALM_TETPY
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLSLMARKMKDTDTEEELIEAFKVFDRDGNGLISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGHINYEEFVRMMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: APT_STUS1
Sequence: MIFDEFSIKTLIRPVPDFPRPGVIFRDITPLFQSPKALRMVADSFIQRYVEADFTHIGALDARGFLVGSILAYELNKPLVLFRKQGKLPADVLSQAYCTEYGEAHLEIHADSLCEGDSVLLFDDLIATGGTLLAAAQLVRRMRASIHEAAAIIDLPELGGSQKLQDIGIPTFTLTAFELSDR
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: ENGB_STRPQ
Sequence: MAEEQVLNTHNASILLSAANKSHYPQDDLPEIALAGRSNVGKSSFINTILGRKNLARTSSKPGKTQLLNFFNIDDKLRFVDVPGYGYAKVSKSERAKWGKMIEEYLTSRDNLRAVVSLVDLRHAPSKEDIQMYDFLKYYDIPVIVVATKADKIPHGKWNKHESVVKKALNFDKSDTFIVFSSVERIGIDDSWDAILEQV
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.