PharMolix/UniProtQA huggingface dataset:
Protein: NHEJ1_RAT
Sequence: MEELEQGLLMQPWAWLQLAENSLLAKASITKHGYALLISDLQQVWHEQVDTLEVSQRAKELNKRLTAPPAAFLHHLDEVLRPLFKDSAHQDAAHPSKATFSCDRGEEVLILRVRSELSGLPFNWHFHCLPASSLLVSQHLICPLMGVSLALHSHVRELAALLRMKDLEIQAYQESGAVLSRGRLKTEPFEENSFLEQFMVEKLPEACAVGDGRPFAMNLQSLYVAVTKQQVQARQKHKGSGEPQTSSSTSPQGTDSQLQNQPEQQISPTPTLSEPECEPMAASGPVHRAQLVKAKRKKPRGLFS
What is the function of this protein?
DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination.  Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends.  Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends.  May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary.  Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired.  The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other.  The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors.  Binds DNA in a length-dependent manner.
What are the official names of this protein?
Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor.
What is the protein family that this protein belongs to?
Belongs to the XRCC4-XLF family. XLF subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer.
Protein: NPY_LAMFL
Sequence: MMSCFAGTRGSARVWLCAIALCLLASSCARGAAAFPNKPDSPGEDAPAEDLARYLSAVRHYINLITRQRYGKRTLTEPYVPEFIFQENRGDRSSNPRFDSVTMW
What is the function of this protein?
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
What are the official names of this protein?
Neuropeptide Y, NPY.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZAPD_VIBVY
Sequence: MTTHNFEHPLNEKTRIYLRVESLLRQAHTAASFSEPHQHQLFFRSIFDLIEIFEQIQLKSELAKDIEKQRLLYRSWLNVEGVDQATLRSLLDEADRTHAALMQAPRFGQSLKEDRFLSSIRQRFSLPGGSCCFDLPALHYWLNLPIERKIEDARQWLDSLKPLSDALNLWLKLAREAGHFRSQTALNGFFQSDAEEANILRLHIPMEYGVYPMISGHKNRFAIKFINFETGQACSQDVHFELAVCS
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: TILS_BART1
Sequence: MCVRLARNLFKTSDFIPCRRVILAVSGGSDSLALMFLVKEYLETLLIPPEIIAVTVDHQLRKESAREAEIVAEICRDHHIKHITVRWEGKKPKTHLAFSARIARYDLLVQEAQKQGASLIMTGHTLNDQVETYQMRCQRLQKRRGALRDEVGAMCDGGAASGFAGALRDKAGARRDEDYVRETRKNIAEKSYGVLYERGLSCIPREALLHRKVRLIRPLLGVQRQTLRNYLRLQGKTWIDDPTNEDRNFERVRVRQSLSSQKLVNIAQKINKAAWQRRQQAQNIADLILALDITVQYGRCFIVKPAPFLQKHSCFPFVVGLFAVLMGGGFYLLSNQKLSMLVQKLCLNSPEKRRFTCAGCVIEYNKEGIALWRERRNMKEALVEPDETLLWDGRYRITNHGSEAIKVGVANLEQLKSLLQNSNSNLEKPHFPSLQSLLMLSNDKGCDIPELISQAIIHKNVIIKRIMAPFDWLSSREDAALVNVVEPFFNLEVKR
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBIJ_ECOLI
Sequence: MKTINTVVAAMALSTLSFGVFAAEPVTASQAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSGTAVIYK
What are the official names of this protein?
Uncharacterized protein YbiJ.
What is the protein family that this protein belongs to?
Belongs to the BhsA/McbA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EFG_AQUAE
Sequence: MAREVPIEKLRNIGIVAHIDAGKTTTTERILYYTGKTYKIGEVHEGAATMDWMPQEKERGITITVATTACYWTRNGERYQINIIDTPGHVDFSVEVVRSMKVLDGIVFIFSAVEGVQPQSEANWRWADRFQVPRIAFINKMDRLGADFYRVFKEIEEKLTIKPVAIQIPLGAEDQFEGVIDLMEMKAIRWLEETLGAKYEVVDIPPEYQEKAQEWREKMIETIVETDDELMEKYLEGQEISIDELRKALRKATIERKLVPVLCGSAFKNKGVQPLLDAVIDYLPSPIDLPPVKGTNPKTGEEEVRHPSDDEPFCAYAFKVMSDPYAGQLTYIRVFSGTLKAGSYVYNATKDEKQRAGRLLLMHANSREEIQQVSAGEICAVVGLDAATGDTLCDEKHPIILEKLEFPDPVISMAIEPKTKKDQEKLSQVLNKFMKEDPTFRATTDPETGQILIHGMGELHLEIMVDRMKREYGIEVNVGKPQVAYKETIRKKAIGEGKFIKQTGGRGQYGHAIIEIEPLPRGAGFEFIDDIHGGVIPKEFIPSVEKGVKEAMQNGILAGYPVVDVRVRLFDGSYHEVDSSDIAFQVAGSLAFKDAAKKADPVLLEPIMEVEVETPEKYVGDVIGDLNSRRGKIMGMENKGVITVIKAHVPLAEMFGYATTLRSLTQGRGTFIMKFSHYDEVPQQIAEKIIGERMAGKSS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCRM_PIG
Sequence: MPFGNTHNKYKLNFKAEEEYPDLSKHNNHMAKALTLEIYKKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYVVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
What is the function of this protein?
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g.  creatine phosphate).  Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
What are the official names of this protein?
Creatine kinase M-type, Creatine kinase M chain, Creatine phosphokinase M-type, CPK-M, M-CK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: PYRDB_THEPX
Sequence: MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVYETPCGMLNSVGLQNSGVDAFIEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVDGIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTVIVKLTPNVGDIGVCAKAAEDGGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGMGGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLKVD
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_TREDE
Sequence: MNSIKLPRTIHIGGKGQVKKLTLGGTSPILLQTMWKESLLGADLLSIVKSLNELEQLGCDIVRFAVPDMDSAEQFVKLTRLTEMPLVADIHFDYKLALRCMDGDTAKIRINPGNIGSKEKTEEVIRKAKDTGTAIRIGVNSGSLPSDLKKKIEEANSKRNLSGDKKALDDEISLLRADTLTEAAARELEIFEKADFKDAVVSMKASNVRETVMANEIFAKKFDNPLHLGVTEAGPLIQGIVKSTIAFYRLLEQNIGSTIRVSLSDSCENEVIAGREILTECGKRQGGIRLISCPRCGRKGFDVQAFVKRWQTKLLSEKKDISIAVMGCVVNGPGEGKHADLGITGAEDSVIIFKHGAITKRLDLKKLTEEEKIKAVDKAFIEELQSL
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ZN555_HUMAN
Sequence: MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQFKASGSVSQQDIYGEKIPKESKIATFTRNVSWASVLGKIWDSLSIEDQTTNQGRNLSRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGERPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYSSAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSHPSSFRGHMRVHTGEKPYECKQCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDKSYECKLCGKAFYCHISLQKHMRRHTAEKLYKCKQCGKAFSWPELLQQHVRTHTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCSSSLRRHVRIHTTEKQYKCNVGHPPANEFMCSASEKSHQERDLIKVVNMVLPL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 555.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLPA_HELPY
Sequence: MGLALEKVCFLGVIFLISACTVKKEGVKNLSYKHESLRAYENAKDYDPTTKKAAYKRNFFERHFKRYSDSQDSNTKDQPLDNGMRDSSSIQRATMRPYQVGGKWYYPTKVDLGEKFDGVASWYGPNFHAKKTSNGEIYNMYAHTAAHKTLPMNTVVKVINVDNNLSTIVRINDRGPFVSDRIIDLSNAAARDIDMVKKGTASVRLIVLGFGGVISTQYEQSFNASSSKILHKEFKVGESEKSVSGGKFSLQMGAFRNQIGAQTLADKLQAENPNYSVKVAFKDDLYKVLVQGFQSEEEARDFMKKYNQNAVLTRE
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: WALR_STAAU
Sequence: MARKVVVVDDEKPIADILEFNLKKEGYDVYCAYDGNDAVDLIYEEEPDIVLLDIMLPGRDGMEVCREVRKKYEMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHYSQPAQDTGNVTNEITIKDIVIYPDAYSIKKRGEDIELTHREFELFHYLSKHMGQVMTREHLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDPSHPEYIVTRRGVGYFLQQHE
What is the function of this protein?
Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins (PubMed:31296851).  Functions as a transcription regulator by direct binding to promoter regions (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein WalR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KMO_RAT
Sequence: MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development.  Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: G6PI1_CLAMI
Sequence: MASPALISETEAWKDLKAHLEGIKRTHLRELMGDTERCQSMMVEFDNIFLDYSRQQAIPDTIKKLYKLADAAHLKQKIDRMYNGDHINSTENRSVLHVALRAPRDSAICSDGKNVVPDVWNVLDKIKDFSDRVRNGSWIGATGKELKDVIAVGIGGSFLGPLFVHTALQTDPEASKNARGRELRFLANVDPIDVARNISGLNPETTLVVVVSKTFTTAETMLNARTLREWISSALGPTAVAKHMVAVSTNIPLVEKFGIDPNNAFAFWDWVGGRYSVCSAVGVLPLSLQYGFAVVEKFLQGAHSIDQHFSSAPFEKNIPVLLGLLSVWNVSFLGYPARAILPYSQALEKLAPHIQQVSMESNGKGVSIDGLPLPFESGEIDFGEPGTNGQHSFYQLIHQGRVIPCDFIGVVKSQQPVYLKGEVVNNHDELMSNFFAQPDALAYGKTPEQLKNENVAEHLIPHKTFTGNRPSLSILLPTLDAYRIGQLLAIYEHRVAVQGFVWGINSFDQWGVELGKSLATQVRKQLHGSRVKGEPVEGFNFSTKTLLTKYLEATSDVPADPSTLLPNI
What are the official names of this protein?
Glucose-6-phosphate isomerase, cytosolic 1, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_NOSP7
Sequence: MTDVPAVRIRNFCIIAHIDHGKSTLADRLLQATGTVEDRKMKEQFLDNMDLERERGITIKLQAARMNYTAKDGQQYVLNLIDTPGHVDFSYEVSRSLVACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKIDLPGAEPERVIGEIEEIIGLDCSGAILASAKEGLGIDEILEAVVERIPPPPNTINERLRALIFDSYYDSYRGVIVYFRVMDGTVRKGDRIHLMASGKEFEIDELGVLSPTQKQVEELHAGEVGYLGAAIRAVADARVGDTITLSKAKAESPLPGYAEANPMVYCGMFPIDADQFEDLREALEKLELNDAALHYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYNLDLIITAPSVVYKVITLKGEELYIDNPSRLPSPNDRQRIEEPYVQVEMITPETYVGSLMELSQNRRGIFKDMKYLAQGRTTLTYELPLAEVVTDFFDQMKSRSRGYASMEYHLIGYRENPLVKLDIMINGDPVDSLAMIVHRDKAYNVGRAMAEKLKELIPRHQFKVPIQASIGSKVIASEHIPALRKDVLAKCYGGDISRKKKLLQKQAKGKKRMKSVGTVDVPQEAFMAVLRLDQS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PQQB_XANOR
Sequence: MRIIVLGSAAGGGHPQWNCHTPASLRAWQQADGAQRRTQASIAVSADGERWVLINASPDFRQQILATPALWPQQGLRHSPIKAVLLTSGEIDHIAGLLSMRESQPFALHASRRVLDLLAQNPIFDAVNPQYVSRQPFTLNAPLTVSGLQLTPFSVPGKVPLFMESRSGGDLAGSQEETLGLTIDDSQHRVHYIPGCAAMTDALRARLHGAELVFFDGTLWRDDEMVQLGISQKTGQRMGHMSIDGPEGTIAAFAPLNVARKIFIHLNTTNPVLNTQSPEFATARASGWEVAHDGLEIAL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: SELU_SHEB5
Sequence: MPNAIVAAEQYREIFLNQHPIMDVRAPIEFTRGAFPNSTNLPLMLDSEREKVGTCYKQSGQQAAIALGHSLVNGPIKQQRIEAWASYVKANPNAYLYCFRGGLRSQLSQQWLKEAGVEVPYIQGGYKAMRQYLIGVIEAAPAQQPLLSLSGMTGCGKTDFLLQRKEAVDLEGIANHRGSSFGKNIDPQSTQINFENQLAIALLQHQTSDAACLLLEDESFLIGRSALPQTFYNAMQAANVLVLEESDDARLERLRNEYVHKMYSGFCERLGPEAGFAAFSDYLLQSLVSIRKRLGGKQHQELQDLMQQALDQQINQNDTSLHLVWINLLLHKYYDPMYLYQLENKSERVLFKGSHQAMHEWLDSYQTR
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: RPOB_POLNS
Sequence: MNYSFTERKRVRKSFAKRVNNHQVPYLIATQLESYAKFLQADKPAMSRLTEGLQAAFTSAFPIVSNNGYARMEYVSYQLSQPPFDVKECQQRGYTYHSALRAKVRLIIYDREAPTKVKEVKESEVYMGEIPLMTENGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRIDRRRKMPVTILLKAIGLNNEQILANFFNFDHFSLTANGGSMEFVPERLRGQLASFDVLDENGVVVIQKDKRINTKHIRELEAAKTKTIAVPDDYLIGRVVARNIVDPDSGEILAYANDEITEELLATLRDAGIKQLETIYTNDLDSGAYISQTLRTDETADQMAARIAIYRMLRPGEPPIEDAVEVLFQRLFYSEDTYDLSRVGRMKVNSRLNRPEMEGPMVLSSEDILDTIKSLVDLRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLSRVERAVKERLGQAETENLMPHDLTNSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRISALGPGGLMRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALFARLNEHGFLETPYRKVSNSKVSDEVVYLSAIEEAKYVIAQANATIDKSGKLADELVSARQAGETMMVSPERIDFIDVAPSQIVSAAASLVPFLEHDDANRALMGANMQRQAVPCLRPDKPLVGTGLERIVAVDSGTVVLAARGGIVDYVDANRVVIRVNDDETTAGEVGVDIYNLIKYTRSNQNTNINQRPIVKVGDRVARGDVVADGASTDLGELALGQNMTVAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELSVVARDTKLGSEEITRDISNLAESQLSRLDESGIVYIGAEVEAGDVLVGKVTPKGETTLTPEEKLLRAIFGEKASDVKDTSLRVPSGMIGTIIDVQVFTREGIERDARAQSIIQEELQRYRLGLNDQLRIVEGDAFMRLEKLLIGKVANGGPKKLAKGTKIDKEYLADLDKYHRFDVRPADDEVASQVEAIKSSIEAKRKQFDEAFEEKRTKLTQGDDLQPGVTKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIAPAEDMPFMADGRPVDIVLNPLGVPSRMNVGQILETHLGWAAQGIGKRVDEMVRQQAKQAELREFLKQLYNETGRIEDIDNFTDEQITVLAENLRQGLPFATPVFDGATEAEIGRMLELAYPEEVATSLKMTPSRQQMILCDGRTGDQFERPATVGVMHVLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVAGRTKVYENIVKGEHTIDAGMPESFNVLVKEIRSLGIEIDMERN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PYRE_METMA
Sequence: MSKTNSETGNNFEQQKQELIAALKACGAVRYGDFTLASGKKSKYYIDIKKASTDPKTLKIIARQAALRIKEMDVDTVAGVELGGVPLATAVSLETELPLLIVRKSVKDYGTKSRFVGDLKPEDRLVMLEDVTTSGGSVRDAIEVVREAGASLKYVITVVDREEGAGEKLKEADVELVPLVSASDLLK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TBC24_XENTR
Sequence: MDDTEYGRFVDWDKMEGGGQEQSTKVLSCTDFQDLKQMARQGHWAKSHSLRAKVYQKLIKEIPCRTVTPDASVYRDIVGKIVGKRPASSLPLPEFVDDRQIPSYCLNSEGIGAVRKIITCISNQFPDISFCPALPSLVALLLHYSQDEAECFENVSRILACNDPNRRLVDQTFLAFESSCMTFGDLAGKYCQGPHKLMVAVSEDVLEVYSDWQRWIFGELPFAYITRVFDVFLVEGYKVLFRVALALLKFFHKVRGGQPMESNNVKRDIQMFVRDLNQCVAPEKLLEKAFAIRLFSRKEIQLLQMANEKALQQKGITVKQKRQNVHLAVHAENFKSEIVSVKEMRDIWSWIPERFALSQPLLLYTNREHGNSLSRFYLHCEGHEPTLLLIKTTNQEVCGAFLSTDWSERRRSGNKLSFFGTGECFVFRLQPEVERYEWVVIKHPELGKVNASSGDNDANSSQSAKDGIDPSDRLSPFLATRHFNLPSKSASMFMAGSTDCIIIGGGDGQALYFDSDLNYGRTSHCNTFNNQPLCSETFQISIIEVWGFKDNVNNDGAHSALP
What is the function of this protein?
May act as a GTPase-activating protein for Rab family protein(s).  Involved in neuronal projections development, probably through a negative modulation of ARF6 function.  Involved in the regulation of synaptic vesicle trafficking.
What are the official names of this protein?
TBC1 domain family member 24.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic vesicle membrane. Presynapse. Note=Mainly cytoplasmatic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
Protein: RL2_EHRCR
Sequence: MGIKNLNSVTASLRGTVLLDKSMLWKGKPEKSLVSYKISRGGRNSRGVITVRHRGRGHKRLYRVVDFKRNKVGVSATVERLEYDPNRTAFIALLSYDDGEKSYIIAPNGLKKGDVVISGDGADILPGNCLLLKSIPVGTFVHNVELRPGNGGVIARSAGTYAQLMSKDGMYVLLRLSSGEIRKVLSDCRATIGIVSNLDNQNVKLGKAGRSRWLGIRPTVRGVAMNPIDHPHGGGEGKTSGGRNPVTPWGVPTKGKKTRKRNKSSNKYIKRVSDKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DMON2_CAEBR
Sequence: MIVPISLLFLFLSFVPFSYSATCDFENEVASMSWMVKGDVLQINFEHKNLTENRWASIAFGNGPGMTNLESIIFSRDDNNVITTNTGFTPKKKKVVVDDVSYVTVRNVQLKGDLLRITVTRPLGPAGPRDFSLDQCVNWIVVPGGALSNGKFKKHHGQIYFVKDVCAAKCTAQRMMRVLSNRIH
What are the official names of this protein?
DOMON domain-containing protein CBG21755.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_PROMH
Sequence: MSLSLWQHCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVREKYINNINALLVDFCGSDVPSLRFEVGNKPVSARTTESVPKTVTHPAVNSTPTNSQPVRPSWDNQPQSQLPELNYRSNVNPKHKFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNSIMERKANAKVVYMHSERFVQDMVKALQNNAIEDFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENQIQLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.