PharMolix/UniProtQA huggingface dataset:
Protein: PSBA_CUSEX
Sequence: MTAILERRESENLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAIEAPATNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid membrane; Multi-pass membrane protein.
Protein: RH16_ORYSJ
Sequence: MAAAAAASSMAKRKQRKAATEQEVENHDEATVAAEAGPENDGHTAHAAEEAAAAEEGVEREGGGEGGAEGEEGPDAAARGGEEGKEEEEREVSFDELGLDEQLKRALRKKGLDKATPIQREAIPLILEGKDVVAKAKTGSGKTFAYLLPMLHELLKLSAEGRIRKSAPNVFILVPTRELCQQVHNEASSLLEFCTSKLKVVQVNASMSDKDIKVALSGPPNILVTTPACVASCISKGIIRGSSIKESLSMMILDEADLLLSYRCEDDIKALVPHIPRSCQSILMSATSSADIEKLTKLLLHNPFILTLTEVGHAKDDLIPKNVQQFWISCDAKDKMLYILVLLKLELIQKKVLIFVNSIDSAFKLRLFLEKFGIRSSVLNAELPQNSRLHIIQAFNARLFDYLIATDDNKSKEERQANKGNKKDSRVSRKQLQQTLDAEFGVVRGIDFKNVFTVVNYDMPPDPAGYVHRVGRTGRANKTGASISLVSPKENGIFEDIENMLKDVENRDTSCISPFPLLTKNAVESLRYRAQDVARSVTTRDIKEARRQDIKNEILNSEKLKAHFDENPRDLDLLKHDKLLSNKEIPAHLRDVPEYLIDPTTKEASNVVKLSRAAMDIDKPRRRKRMGFKGGSGRSSDPLKTFSAEGKSRRRGRKERDGEQDRRKRKKVES
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 16.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
Protein: HBG1_GORGO
Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGGAIKHLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma-1, Gamma-1-globin, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ATPE_TERTT
Sequence: MALTIHCNIVSAEQEIFSGLVELLVAAATEGDVGIGYGHAPFLSALKPGPVRVKKQSGDEEIFYVSGGYLEVQPESINVLADTALRADDMDEASAEAAKKEAEEALASQTGDGIDYSKAAARLAEAAAQLRTLQAIRKRAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WHIA_MYCSK
Sequence: MAMTAEVKDELSRLVVNSVSARRAEVASLLRFAGGLHIVSGRVVVEAEVDLGIIARRLRKDIYDLYGYNAVVHMLSASGIRKGTRYVVRVAKDGEALARQTGLLDLRGRPVRGLPAQVVGGSVADAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVSAKAREVRGSDRVVVRDGEAIGALLTRMGAQDTRLTWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPDHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKQDGIPDTESAVTPDLLEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: H2A1_PICGU
Sequence: MSGGKGKVGSSEKASTSRSAKAGLTFPVGRIHRLLRKGNYAQRVGSGAPVYLTSVLEYLTAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQSLLPSKKSIKGASQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CHLN_HUPLU
Sequence: MAVEISETLTFECETGNYHTFCPISCVAWLYQKIEDSFFLVVGTKTCGYFSQNSLGVMIFAEPRYAMAELEEGDIPAQLNDYGESKRLCIQIIKNRNPSVIIWIGTCTTEIIKMDLEGIAPKLEAEIGVPIVVARANGLDYAFTQGEDTVLAAVTHRCPERKSSVGGQNQPVQDEELQEFFSFLPPNDENVKKTVVGSQKNPPLVLFGSLPSAVAHQPSSELKRQSIQISGWIPTERYNNLPSLGDEVYVCGVNPFLSRTATSLMRRRKCQLIGAPFPIGPDGTRAWIEKICSVFGIEAQGLEKREKKVWDSLENYLDQVRGKSVFFMGDNPLEISLARFLIRCGMTVYEIGIPYMDKRYQAAELYFLQNTCRDMRIPMPRIVEKPDNYNQLQRMYELQPDLVFTGMAHANPLQARGINTRWSIEFTFAQIHGFTNAKEILKLIIRPLKDNNDFKNFDWTNLVRKDNNSLN
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MIAA_AERHH
Sequence: MPTAIFLMGPTASGKTDLAIELCQALPCDIISVDSALIYRGMDIGTAKPSAAELALAPHRLIDILDPAVSYSAADFCKDALREMKEIAERGRIPLLVGGTMLYFKALLEGLSPLPSADPVIRAGIEEEAARLGWQALHDELVRIDPVAGARIHPNDPQRLSRALEVYRISGKTLTELTQVQGEGLPYRVLQFAIAPSDRAVLHQRIELRFDKMLQGGFEQEVRALYQRGDLTPDLPSIRCVGYRQMWDYLAGEVEYDEMRYRGIVATRQLAKRQMTWLRGWSDVTWLESGESGNLARVVARAGVA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ARSC_PRIM3
Sequence: MSKKTLYFLCTGNSCRSQMAEGWAKKYLNNNEWDVRSAGLEAHGLNPNAVKAMKEAGVDISNQTSDVIDPEILNNADLVVTLCGHAADHCPVTPPHVKREHWGFDDPAKAEGTDEEKWAFFQRVRDEIAERIQRFAETGK
What is the function of this protein?
Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
What are the official names of this protein?
Arsenate reductase.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_PSYWF
Sequence: MLTNTDRQQVIAQYQRAPGDTGSPEVQIALLSARINDLQAHFKEHKGDHHSRRGLIRMVNQRRKLLDYLKRKDLTRYASLISELGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SPEH2_BACCZ
Sequence: MEYSTFGKHIIVDLWGVDFSLLDDMYFLEHHLVHAADLSGAHVLNVSTKEFDPHGVTVLVLLSESHLSIHTYPEKNFAAIDCYTCGTTVEPQIAIDYIVSILKPNEMHIKKLIRGIGEIVNTD
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme 2, AdoMetDC 2, SAMDC 2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: TTCA_CHESB
Sequence: MTFHQPVSETAQPDEASGHPLFADAPSSVEFNKLRKRLLRQVRQAFEDFTMVKPGDRWLVALSGGKDSYGLLAVLLDLKWRGLLPVELLACNLDQGQPNFPKHILPDYLTRLGVPHRIEYQDTYSVVTEKIPENRTYCSLCSRLRRGHLYRIAREEGCSSLVLGHHREDILETFFMNFFHGGRLAAMPPKLLNDEGDVLVLRPLAYCAETDLVKFAEGMKFPIIPCDLCGSQDGLQRNAMKAMLEDIERRMPGRKDTMIRALANVRPSHLLDRQLFDFAGLGIL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTE1_YEAST
Sequence: MEIFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIELNEPDKLDFDAWLHYSLKDFTQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPDNTSNVYSKHRIAKEPSVDNESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILNSLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIKPANQKPEMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSAMDNLDLYQTVSSIAQSVISLTNTLNKQLQNNESNMQPSPSYDALQRRKVKSLTTAYYNKMHGSYSAESMRLFDKDNSSSRTDENGPQRLLFHETDKTNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLNLREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDNSLDASSEANNYDITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIAITPTKELSIVDPEQNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTVISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSRDLPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNNDLESPSTHAKNNKYFFSPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANSESAFTGSLNKKNLNEIANMLDDSINDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNKFDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELST
What is the function of this protein?
Involved in proprotein-processing like proalpha factor-processing in the secretory pathway.
What are the official names of this protein?
Guanine nucleotide exchange factor LTE1, Low temperature essential protein 1.
What is the protein family that this protein belongs to?
Belongs to the LTE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud. Note=The localization to the bud requires interaction with KEL1, as well as the presence of septins, CDC42, CLA4 and RAS2.
Protein: MDTB_YERP1
Sequence: MQVMPPTPGGGPSRLFILRPVATTLFMIAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVVTSSITAPLERQFGQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPYPPIYNKVNPADPPILTLAVTATAIPMTQVEDMVETRIAQKISQVTGVGLVTLSGGQRPAVRVKLNAPAVAALGLDSETIRTAISNANVNSAKGSLDGPTRSVTLSANDQMKSAEEYRDLIIAYQNGAPIRLQDVATIEQGAENNKLAAWANTQSAIVLNIQRQPGVNVIATADSIREMLPELIKSLPKSVDVKVLTDRTSTIRASVNDVQFELLLAIALVVMVIYLFLRNAAATIIPSIAVPLSLVGTFAAMYFLGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLDAALKGAGEIGFTIISLTFSLIAVLIPLLFMEDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSYESLRKQNRLSRASEKFFDWVIAHYAVALKKVLNHPWLTLSVAFSTLVLTVILYLLIPKGFFPLQDNGLIQGTLEAPQSVSFSNMAERQQQVAAIILKDPAVESLTSFVGVDGTNATLNNGRLQINLKPLSERDDRIPQIITRLQESVSGVPGIKLYLQPVQDLTIDTQLSRTQYQFTLQATSLEELSTWVPKLVNELQQKAPFQDVTSDWQDQGLVAFVNVDRDSASRLGITMAAIDNALYNAFGQRLISTIYTQSNQYRVVLEHDVQATPGLAAFNDIRLTGIDGKGVPLSSIATIEERFGPLSINHLNQFPSATVSFNLAQGYSLGEAVAAVTLAEKEIQLPADITTRFQGSTLAFQAALGSTLWLIIAAIVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLTGNELDVIAIIGIILLIGIVKKNAIMMIDFALAAERDQGMTPYDAIYQACLLRFRPILMTTLAALFGALPLMLSTGVGAELRQPLGVCMVGGLIVSQVLTLFTTPVIYLLFDKLARNTRGKNRHRDEDIDSSELLNGQEPQ
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DXR_WOLWR
Sequence: MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDERLYKDLKESLLGTDVKIAIGATNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANKESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDKCVEKIILTASGGPFLNYSLEQLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIVHGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPVLKLSMEVLNSSTPQTNSIVLNAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINSLSDIINIDCESRIIAHKIVESKVVAYS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: GATC_STRP4
Sequence: MKITQEEVTHVANLSKLRFSEKETAAFATTLSKIVDMVELLGEVDTTGVAPTTTMADRKTVLRPDVAEEGTDRDRLFKNVPKKDNYYIKVPAILDDGGDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: Y599_YERPB
Sequence: MFRWGIIFLIIALIAAALGFGGLAGTAAWAAKVVFVVGIILFLISLFTGRKRL
What are the official names of this protein?
UPF0391 membrane protein YPTS_0599.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PFKA_STRP4
Sequence: MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGMVAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSHRRTFVIEVMGRNAGDIALWAGIATGADEIIIPEADFKMEDIVASIKAGYECGKKHNIIVLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLLKEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSLS
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PD_KLULA
Sequence: MATQFDENTVITIFGASGDLSKKKTFPALFGLYREGYLNPTTKIIGYARSKLSNEDLREKVKPFLKKPNGAKDDAKVNEFLSMVSYHAGPYDSDEGYLELKKIIEEFEAEKKVDEPHRLFYLALPPSIFIDVCSKLKENLYTESGIQRVIVEKPFGHDLQSATELQEKLAPLFSEDELFRIDHYLGKEMVKNLLLMRFGNTFLNAAWNKENIQSVQVVFKEPFGTEGRGGYFDSIGIIRDVMQNHLLQVLTLLTMERPVSFDPESVRDEKVKVLKAFSPIDHDDILIGQYGRSVDGSKPSYLDDETVKEDSKCVTFAAIGFKIANERWDGVPIVMRAGKALNEGKVEIRIQFRRVASGMFTDIPNNELVIRIQPNEAIYLKCNAKTPGLANENQTTELDLTYSERYKNYWIPEAYESLIRDALLGDHSNFVRDDELDVSWKLFTPLLNYLEGPDGPQPKIYPYGCRSPDGLVEFLADHGYTFSKPGSYQWPVTTPKM
What is the function of this protein?
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.  The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: HIS4_PROM1
Sequence: MEIIPAIDLLNGKCVRLNQGNYNEVTKFNSDPVKQAQIWESKGAKRLHLVDLDGAKTGEPINDLTIKEIKKSITIPIQLGGGIRSIDRAKELFDIGIDRIILGTIAIEKPELVKDLSKEYPKRVAVGIDAKEGMVATRGWLKQSKISSLDLAKQLNDLDLAAIISTDIATDGTLKGPNVQALREIAEISINPVIASGGIGSIADLISLADFADEGIEGIIVGRALYDGSIDLKEAILTLKNLLLQDAFNEKDKFLV
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGR1_ASHGO
Sequence: MALFTPPSEDKDGRDRSGGGDKASGVVRTPFHLRPSLGLALWGPLVPASDNRAGLWTLVGLQTLMGAFFVSRFRALRPKLLKRDIADFPSLNRFSKTSGDMHVGPVHVFADFGGTHSFHRRAGESPGFFQSRRFVSLKRALYLSTGVVLLVQSALESARLTLLVYDPWEEQARGVRDKQFYNDVVRYYHEGVDPARFIVKDPASGNTLPVNVPEVKQGVALARAHTNARNIITRWLGPLDCKPLSSSEFLDKLEHYLDTCDFIQDMNNKRLFGNPAEVKARQKALDALIQANKENRRRIRHILDITPPRGLPLSPKAVDQGLRSIILDPDHESTEDLDLHELWSIYNPWVDLALDTSLSIKFLPTVRTPEELLGDSEDTAVEQKNPPVQIKRERG
What is the function of this protein?
Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
What are the official names of this protein?
Mitochondrial inner membrane i-AAA protease complex subunit MGR1.
What is the protein family that this protein belongs to?
Belongs to the MGR1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LPAR1_BOVIN
Sequence: MAAAFTSSPVVSQPQFTAMNEQQCFSNESIAFFYNRSGKYLATEWNTVTKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTVSVANLLAIAIERHITVFRMQLHARMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSDRSASSLNHTILAGVHSNDHSVV
What is the function of this protein?
Receptor for lysophosphatidic acid (LPA).  Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents.  Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.  Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels.  Signaling triggers an increase of cytoplasmic Ca(2+) levels.  Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate.  Signaling mediates activation of down-stream MAP kinases.  Contributes to the regulation of cell shape.  Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction.  Promotes the activation of Rho and the formation of actin stress fibers.  Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1.  Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding.  Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14.  Promotes cell proliferation in response to lysophosphatidic acid.  Required for normal skeleton development.  May play a role in osteoblast differentiation.  Required for normal brain development.  Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus.  Plays a role in pain perception and in the initiation of neuropathic pain.
What are the official names of this protein?
Lysophosphatidic acid receptor 1, LPA receptor 1, LPA-1, Lysophosphatidic acid receptor Edg-2, Rec1.3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.
Protein: TRPD_STAAC
Sequence: MTLLTRIKTETILLESDIKELIDILISPSIGTDIKYELLSSYSEREIQQQELTYIVRSLINTMYPHQPCYEGAMCVCGTGGDKSNSFNISTTVAFVVASAGVKVIKHGNKSITSNSGSTDLLNQMNIQTTTVDDTPNQLNEKDLVFIGATESYPIMKYMQPVRKMIGKPTILNLVGPLINPYHLTYQMVGVFDPTKLKLVAKTIKDLGRKRAIVLHGANGMDEATLSGDNLIYELTEDGEIKNYTLNATDYGLKHAPNSDFKGGSPEENLAISLNILNGKDQSSRRDVVLLNAGLSLYVAEKVDTIAEGIELATTLIDNGEALEKYHQMRGE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: SMOX_HUMAN
Sequence: MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT
What is the function of this protein?
Flavoenzyme which catalyzes the oxidation of spermine to spermidine.  Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions.  Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.  May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
What are the official names of this protein?
Spermine oxidase, Polyamine oxidase 1, PAO-1, PAOh1.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm. Nucleus.