PharMolix/UniProtQA huggingface dataset:
Protein: STT3A_PONAB
Sequence: MTKFGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSICWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGFDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT
What is the function of this protein?
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity).  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.  This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity).  STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (By similarity).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, Oligosaccharyl transferase subunit STT3A, STT3-A.
What is the protein family that this protein belongs to?
Belongs to the STT3 family.
Protein: FTSW_GEOS8
Sequence: MRRVEGYDMIVLMMAVILTCFGVVMVYSASSVMAAKKFHDGFFFLKRQSLYALIGFIGMGVAMHVDYHVWKKWAVPLFLGTFFLLLLVFVPGIGGTAKGASRWIRLPGFNFQPSELAKVALIMYMAYSLEKRQDKLKQFMSGFFPYMLILGVFIAVLLAQHDMGAALTMLAVAIVMLFAAGTKVQYILGMGLVALPGICYLVFTKAYRMRRITAFLDPWQDPTDAGFQIIQSWLALGTGGFFGQGLGEGKQKLFYLPEAHTDFILSVLGEEMGFIGVVVIASMFLLLVQRSIRVAIAAEDSFGRFLAFGIAILLGLEAFVNMAVVTGLLPTKGIALPFLSYGGSSLIISLCSVGVLLNVSTRMRGAA
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: CYSG_ECOL5
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDALNQRVSEAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEYGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: T183B_HUMAN
Sequence: MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYADSDLAVVRSGRVKKAVANAVRQEVKSLCGLEASQVPAEEALSGAGEPYDIIDSSDEMDAQEENIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA
What are the official names of this protein?
Putative transmembrane protein 183BP, Transmembrane protein 183B pseudogene.
What is the protein family that this protein belongs to?
Belongs to the TMEM183 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PLK4_DROGR
Sequence: MLPFRNYGETIDEYEVQHLLGKGGFACVYKAKCLRTQQNVAIKMIDKKLIQGSGLSSRVRQEVEIHSRLKHPSVLQLHTFFQDGNYVYLVLELADNGELHRYMNQQMKRPFTEQEASSILRQVVDGLLYLHSHNIMHRDISLSNLLLSRDMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSHMSHGLPADLWSVGCMLYTLLVGRPPFDTDAVQSTLNKVVLSDYTMPSHLSYEARDLIEKLLRKNPHERISLEQVLRHPFMVKAGGGSIISYTTTPGASDGYGQSIASGDSGIVTFASNDSKNSQRHMLPQIQEEFGYYQEQRKNYAPHPVYRQSSAEPLNSTEMEWQRIGQSNGHFLAHSTPATGGQVAAKKNNAECISMPPLNTLRLQPTRYKTKNAIMSIMANGEVVIEFIKCKSKMNEDRIVDICRISGDGRRIIIYQPDPGRGLPIRDQPSAVQPENYAYNYDNLPSKHWKKYVYAARFVSLVKSKTPKVTYFSGLAKCHLMENMADFEMCYYSGAKLTKSPTDAVKLYNKHGLLITDQTSGEAMRWIEHSNECFAHCLSICNALELAQTGSNTCFPVTIGRRPTPEVMPSQQRADGLRDTTNFAYSTPKSQQGSINFSISTISSMRSGNDLIGSQLLAAQQNVPIKRLNVPGVGTATELSHGIVQVQFYDGSVISIIPETQGGGITYTQSSGLSTHFPDHDDLPIAVRDRLSQLPQVQMKLKSAPLIGSKKFDCKTTTESAPWHNRMLI
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: MOAC_SHEB9
Sequence: MSNVFTHINADGNAHMVDVTEKAITEREARAEAFIEMASTTLEMIMSGSHHKGDVFATARIAGIQAAKKTSDLIPLCHPLMLTKVEVDLEAQPEHNRVRITSLCKLSGKTGVEMEALTAASVAALTIYDMCKAVQKDMVISQVRLLEKRGGKSGHFKV
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RPOZ_ALBFT
Sequence: MARITVEDCLEQIPNRFQLVLAATYRARMLSQGHAPKVDCKNKPAVTALREIAAGKIGLEMLKKVPL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: LUXS_SHIF8
Sequence: MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGSHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: Y5204_STRCO
Sequence: MPDRGGGPPTGPRIRVGRPSRRVRTLLLTLGVLAVLAMAFTMFAGFWTDWLWYRSVHYSSVFTTTLWTKIGLFFVFGLLMALAVGFNIWLAHRLRPPLSAMSMEQQNLDRYRMGIAPYKKWLLLGITALVGLIAGASASGQWRTWLMWVNGVPFGQKDPQFKLDVSFYAFDLPWYRFLLGFGFAAVIISVIAAALTHYLYGGLRVTSPGARATAAATGHLSVLLGVFVALKAVAYWLDRYGLAVKSSDFKATDNWTGLRYVDANAYLPAKTILFCIAVICALLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPALVQKFQVQPNEQAKEAPYVEKNLAATRDAYGIEGTQVAEYPGKSETKDKTKLRDDADAAASVRIMDPNIISPTFQQLQQMRNYYAFPTNLDVDRYAKDGKDQDTVIGLRELNLAGIPKKNWINNHFRYTHGYGVVAAKGTQVDSEGRPVFTESNLPSEGDLGKYEQRIYYGEKTTTYSIVGGPQKEIDYSDDTGEKTFSYKGDGGVDLSNPINRAAYAAAFSEPQILYSGAIGDGSRILYNRTPKERVEAVAPWLTIDGDAYPAVVDGRIQWIVDAYTTTNGYPYASRTTLGDTTADSLTANNNSRAVVAQQNQVNYIRNSVKATVDAYSGDVKLYEWDTQDPVLKTWKKAFPGTVQDKGEISKELMAHLRYPQDLFKVQRELLTRYHVKDANTFLSGSEVWQVPDDPTNKSGDAVPPYYLSMKMPDQKAQAFSLTTTFTPNGRDNLSAFMAVDAEAGTSDYGKIRILKLPTSTTVDGPKQVQSQFNSEQDIAESIRLLRGGDSEVEYGNLLTVPLDGGLLYVEPVYVRGGDLKYPLLRKVLVSYGGNTAFENTLDAALNKVFGAQAAETEQPPDEGDDTTEPPPTSTNPTVREALSDAQKAFDAGQKALEQKDLAAYAEAQKDLEEALQRAEDAQAKADQGAGGKNGDDKNAGDKNSGDKAGSDKAGPDATPTGDAGGGADTG
What are the official names of this protein?
UPF0182 protein SCO5204.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OR8B8_HUMAN
Sequence: MAAENSSFVTQFILAGLTDQPGVQIPLFFLFLGFYVVTVVGNLGLITLIRLNSHLHTPMYFFLYNLSFIDFCYSSVITPKMLMSFVLKKNSISYAGCMTQLFFFLFFVVSESFILSAMAYDRYVAICNPLLYMVTMSPQVCFLLLLGVYGMGFAGAMAHTACMMGVTFCANNLVNHYMCDILPLLECACTSTYVNELVVFVVVGIDIGVPTVTIFISYALILSSIFHIDSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPFSLLAMNQGKVSSLFYTTVVPMLNPLIYSLRNKDVKVALKKILNKNAFS
What is the function of this protein?
Odorant receptor (Potential).  May be involved in taste perception.
What are the official names of this protein?
Olfactory receptor 8B8, Olfactory receptor TPCR85, Olfactory-like receptor JCG8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KLKB1_HUMAN
Sequence: MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
What is the function of this protein?
The enzyme cleaves Lys-Arg and Arg-Ser bonds.  It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface.  It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
What are the official names of this protein?
Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, PKK.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNY_STAAW
Sequence: MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLEAKEENQILREQTEAELRERRSELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEEKQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQRVEEELSQDIAVLVKEKEKEAKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIREAGEQATFEVNAHNMHPDLVKIVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVINAIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDDLKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y, Conserved virulence factor A.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NADE_STAAS
Sequence: MSKLQDVIVQEMKVKKRIDSAEEIMELKQFIKNYVQSHSFIKSLVLGISGGQDSTLVGKLVQMSVNELREEGIDCTFIAVKLPYGVQKDADEVDQALRFIEPDEIVTVNIKPAVDQSVQSLKEAGIVLTDFQKGNEKARERMKVQFSIASNRQGIVVGTDHSAENITGFYTKYGDGAADIAPIFGLNKRQGRQLLAYLGAPKELYEKTPTADLEDDKPQLPDEDALGVTYEAIDNYLEGKPVTPEEQKVIENHYIRNAHKRELAYTRYTWPKS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RECR_STAA1
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAQRLAFHTLDMKEDDVVQFAKALVDVKRELTYCSVCGHITENDPCYICEDKQRDRSVICVVEDDKDVIAMEKMREYKGLYHVLHGSISPMDGIGPEDINIPSLIERLKSDEVSELILAMNPNLEGESTAMYISRLVKPIGIKVTRLAQGLSVGGDLEYADEVTLSKAITGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: GLPK_SHIFL
Sequence: MTEKKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKPIYNAIVWQCRRTAEICEHLKRDGLEDYIRSNTGLVLDPYFSGTKVKWILDHVEGSHERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGFWQNLDELQEKAVIEREFRPGIETTERNYRYAGWKKAVKRAMAWEEHDE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: FLIE_ECO27
Sequence: MSAIQGIEGVISQLQATAMSARAQESLPQPTISFAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLVAAYQEVMSMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RL36_BACP2
Sequence: MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: TORD_ECO5E
Sequence: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLTAAVDELENRVATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPTDHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALRQWLPEFVARCHQYDSFGFYAALSQLLLVLVEGDHQNR
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I77AA
Sequence: MKAKLLVLLCALSATDADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCRLKGIAPLQLGKCSIAGWILGNPECESLFSKKSWSYIAETPNSENGTCYPGYFADYEELREQLSSVSSFERFEIFPKERSWPKHNITRGVTASCSHKGKSSFYRNLLWLTEKNGSYPNLSKSYVNNKEKEVLVLWGVHHPSNIEDQKTIYRKENAYVSVVSSNYNRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNASMDECDTKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSTKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLEKRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: ISPD_LARHH
Sequence: MSRCLALVPAAGGGSRMGADRPKQYLDLAGAPLLAHTLRRLLAEPRLARVLVVLAPDDVWFDRFDWPRDVRLEILRVGGATRAESVRNGLLHAGAAADDWVLVHDAARCCLPPDALDRLIDTLQADPVGGLLALPVADTLKRETSGQRVAQTVSREGLWLAQTPQMFRAGMLALALDRPLDRAVTDEASAIERLGLVPRLVTGDALNFKVTWPHDLVLARAVLGLDNAGK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: KHSE_SYNP2
Sequence: MTSIHVQVPATTANIGAGFDCLGAALSLHNQFQFRLAGESEPFFSLELVGADVETQKLEATADNLLYRAFAKVFATLGQPVPHVNIAIDLKVPLSRGLGSSATAIVGGLVGANALAGSPLSQREIMNLAIEMEGHPDNVVPALLGGCQLSVKHQQDWVICPWVWHENVVPVVAIPDFELSTEEARAVLPQQYARAQAIFNASRLGLLPHGLAQNNPEYLTAALDDQIHQPYRKNLIKGYDPVQQAAIAAGAYGMVISGAGPTLLALAAPENAPKVATAMQTAWEGIGVKAIAHVLEIDQQGTVIL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_RHILO
Sequence: MTLSFDLTTEGARDALRARAAPEKPSLIGLTRAELGEALVASGIVPERQAKMRAQQLWHWMYVRGVSDFAGMFNISKDLRAELDKHFTVARPEIVEEQISSDGTRKWLFRFPPRGAGRPVEIETVYIPEEGRGTLCISSQVGCTLTCSFCHTGTQKLVRNLTTEEILAQLLTARDRLGDFPDRDTPDGAIVPAEGRKVSNIVMMGMGEPLYNFEAVKKALLIASDGDGLSLSKRRITLSTSGVVPEIFRTGEEIGVMLAISLHATNDDLRDLLVPINKKYPLKELIAACRAYPGLSNAKRITFEYVMLKDVNDSIEDAKGLIKLLKGIPAKINLIPFNPWPGTNYQCSDWETIEKFADYINNAGYASPIRTPRGRDILAACGQLKSESERMRKVDRLALEAMMIAGHGEA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX31_CONTE
Sequence: MLSTMQTVGAVLMLSIVLVAGRKRHHCDSKYYELTPAHTMCLTDKPNAVAVPLTQETEHEILEMHNKIRADVTDAANMLKMEWDERLATVAQKWAMQCILGHDSGRRGEPDLPGSVGQNVAWSSGDLTFLGAVQMWADEIVDFQYGVWTDGTGHYIQQVFAGASRIGCGQSACGNNKYFVCNYYKGTMGDEPYQLGRPCSQCRSSCQHIRGSQGRWGSLCDCTNGPDACFNGGIFNINTCQCECSGIWGGADCQEKHCPNEDFDDMCRYPDALRRPQHWCQYDNFQSDCPILCGYCPNPN
What is the function of this protein?
Protease responsible for cleaving the conotoxins from their propeptide precursors.  The target propeptide requires minimum four residues including a leucine N-terminal of the cleavage site for efficient substrate processing (example: Xaa-Xaa-Xaa-Leu-Asn-Lys-Arg-toxin).
What are the official names of this protein?
Cysteine-rich venom protein, CRVP, Substrate-specific endoprotease Tex31.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDC_XYLFT
Sequence: MNQTRVLLIFSWLTVATLLWMDWSKNKNETLEISASHNLGVDSNLELEHAVPQIHAGAVPLQKDSQLIAAAPKVPVINVTTDVLQLKLDGFSILAADLLRFPQSKDRGAKPIKLLTDDPNYPYSATTGWVSQSNSPVPNLSTFLPEQPDVSYKLANDQNRLVVPFIWTAANGVSIRRTFTFERGRYAILIRDEIRNSGETPWNAYVFRKLSRVPIPNILNRAMTNPDSFSFNGAVWYSEKGGYERRAFKDYMNDGGLNREIGGGWIALLQHHFFTAWIPQKDQASLYLLAQNGSRDIAELRGPAFTVAPGQTTTTEARLWVGPKLVEQITKEHVKGLDRVVDYSRFQLMALIGQGLFWILSHLNSLLHNWGWAIVGLVVLLRIAMYPLSASQYKSAAKMRKFQPRLQQLKERYGEDRQKFQQAMMELYKKEKINPMGGCFPILIQMPIFFALYWVLVESVELRQAPWLGWIQDLTTRDPYFILPLLNIVIMWATQKLTPTPAGMDPIAGKMMQVMPLIFGVMMAFVPSGLALYWVINGGLNLLIQWWMIRQHADFSRKRSRENIK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.