PharMolix/UniProtQA huggingface dataset:
Protein: ADPP_BACSU
Sequence: MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPGAVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAKKLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVESREVYDAKTAYAIQYLQLKEALQAQK
What is the function of this protein?
Acts on ADP-mannose and ADP-glucose as well as ADP-ribose.  Prevents glycogen biosynthesis.  The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity).
What are the official names of this protein?
ADP-ribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, ASPPase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudF subfamily.
Protein: MRAY_BACAA
Sequence: MLEQGLLVTAGVAFLISVALSPLFIPFLRKLKFGQSIRDEGPKSHQKKSGTPTMGGIVIYVSMMVTSLIMAIKFNHLGAEVSLLLLVTFGYGLIGFLDDYIKVVKKRNLGLTSKQKLVGQLVIAIAFFFIGKGQAFHTYIMIPGTDVKFELGWAYFVLVLFMLIGGSNAVNLTDGLDGLLSGTAAIAFGAFSIIAVAQEQFGVAIFCMAVVGAVLGFLVFNANPAEVFMGDTGSLALGGAIAAVAILLKQELLLVIIGGVFVMETLSVIIQVISFKTTGKRVFKMSPLHHHYELCGWSEWRVVVTFWSVGFLLAVLGIYIGVWM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PURA_FRATM
Sequence: MSNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEITRLQAKGIAISAENLFVSESCTIITSYHKLLDAVRESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRSRLAISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDKAIAAGKNVVYEGAQGVLLDVDYGTYPFVTSSNTSVAGVYSGATTAGHGFDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCAYPGIDLYKVEPILVEMEPFSIDETVTKDNMPAALKTYLETIENHVGIPISSLAYGPSREQILFFEDYFKKG
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFXQ_GUITH
Sequence: MSISNETTVNLQEEYEKRQIQEVLDELDRDLVGLIPVKTRIKEIAALLLVHRLRKLLGLTSANPGLHMSFTGSPGTGKTTVALKMADILFRLGYVRKGHLITVTRDDLVGQYIGHTAPKTKEVLKRAMGGVLFIDEAYYLYKPDNERDYGAEAIEILLQVMENQRDDLVIIFAGYKDRMDSFYESNPGLSSRVANHIDFPDYTPEELLIIGKIMLEEQQYRLTKESELVLLDYIKLRMKEPHFANARSVRNAIDRARMRQANRMFNAGDKVLTKSDLVTIQPEDLLKSRLFKK
What is the function of this protein?
Necessary for the expression of RuBisCO.
What are the official names of this protein?
Protein CfxQ homolog.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y8823_DICDI
Sequence: MNNLKKNDKEVLEEFANLFPILLNEIKKELEKIDFPKESIHWIETVIKANSTGGKMNRGISVLESLESLNEGRALTRHEIFQAQTLGWCVEIFQACYLVSDDIMDQSLKRRGKPCWYKQKRPNSDQEVGLAAINDSFIIESCVFILLEKYFKNESYYLNIVELFHKTGFQTQLGQLLDLTTQPIRGDFSSINLKNHTRITEYKTAYYSFFFPVALAMLMSKINHEQAFTTAKDILLPMGVYFQVQDDFLDCYGSPEVFGKIGRDIEENKCSWMICQAILNGTPDQINLLKKHYGFDNPTDVEIVKKIYKEINLEKIFKDYENTSYNFLIDKIKTTCIYLPPSVFLKILSKIYKRDK
What is the function of this protein?
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a sterol precursor.
What are the official names of this protein?
Probable farnesyl diphosphate synthase DDB_G0278823, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_POLOR
Sequence: MNPYILSIMLISLGLGTTLTFASSNWLLAWMGLEINTLAIIPLMANNHHPRAVEAATKYFITQAAAAALLLFSSLINAWQSGQWMIQDMSMPMSALMTIAIAIKLGVAPVHFWLPEVMQGIKLNTGLILATWQKLAPLALLYQISNNLMPELMIALGLMSTIVGGWGGLNQTQIRKIMAYSSIAHLGWIISIMHFMPSLAIINLIMYIIMTTTMFMIFNTLNSTTINALAINWSKFPALSAITMLALLSLGGLPPLSGFLPKWLILQELTNQNLALTATVMALSALLSLYFYLRLSYSLTTTIMPNTYQHMLNWNIKTKITFILPTMMIMTIAMLPISPSIISMF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CRGN_HUMAN
Sequence: MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWVKNCVNTIKVYGDGAAWSPRSFGAEDFQLSSSLQSDQGPEEATTKPATTQPPFLTANL
What are the official names of this protein?
Gamma-crystallin N, Gamma-N-crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: SPA38_BOVIN
Sequence: MRAERMSPLLALGLLVSGLCSRVHCLPENVTPEERHKGTSVDGHSLASSNTDFAFSLYKQLALKNPNKNVIFSPLSISIALAFLSLGARGPTVTEILEGLKFNLTETLEREIHQGFQHLLQMLSRPSNELQLSVGNTMFVQEQLKLLDKFREDALALYTSEAFSTNFKDPETAKSLINDYVKNKTRGKIVDLFKDLDPLTKVILVNYIYFKAQWRTPFDPKQTYKSQFHVSKNKTVEVPMMSIGDLVTPYFRDEELDCTLVELTYTSNDSALFILPDEGKMQDLEAKLIPEMLTRWRESLYPRGIHELNLPRFSIATDYKLKDILSQLEIKKVFTQEADLSGITDDHELEVSQVVHKAVLDVGEEGTEGAAATGVKVGITSINNHIPLSFNRPFLIAIVLKDTQSIIFLGKVTNPSQA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Serpin A3-8.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted.
Protein: RUVA_ECOBW
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDASSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: NTPPA_NEIG1
Sequence: MNTLYLGSGSPRRMEILTQLGYRVVKLPAGIDETVKAGETPAPYVQRMAEEKNQAALTLFCETNGAMPDFPLITADTCVFSDGIILGKPRSQAEAIEFLNRLSGKQHTVLTAVCIHYRGKTSSRVQTNRVVFKPLSSEEISAYVQSGEPMEKAGAYAVQGIGGIFIQSIEGSFSGIMGLPVYETVSMLQDLGYRPPLSALKP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_PSEE4
Sequence: MRHYEIIFLVHPDQSEQVGGMVERYTKLIEEDGGKIHRLEDWGRRQLAYAINNVHKAHYVMLNVECTGKALAELEDNFRYNDAVIRNLVIRRDEAVTGPSEMLKAEENRSERRERRERPEHADGAEGDDSNDSDNSDNADE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: DNAA_CLOBA
Sequence: MDADLNKLWEKTLNIVKSEMSEVSFNTWIKSCEPISISDTSIKISVPNSFTKDILDKRYKSLVANSIEAVCSKLYDIKFIIESDLNNEDELNSSDNSIKNRNKNSTKNIVVNDEMSSTLNPKYTFNSFVIGNSNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYILQNNTKAKVVYVSSEKFTNELINAIKDDKNEEFRKKYRNVDVLLIDDIQFIAGKERTQEEFFHTFNELHDANKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQVPDFETRMAILKKKADVENLKVANEVMGYIATKIKSNIRELEGALIRIIAYSSLTNREVTVDLASEALKDIISKKQGKHVTIPSIQEIVANYFNLKIDDLKSQRRTRNVAYPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISENLKSDENLQHTVSDITKKVSQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2079_RHIL3
Sequence: MDISRTEQRILHLMAQGGRIEITRDDDRKIEAVSCFTRDGWLYPGVDLDLFRRLKRLRAIKSSGGQPYRITERGLRLVRSQLNNR
What are the official names of this protein?
UPF0386 protein RL2079.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: NS1_AEDEV
Sequence: MEYGLISKFYMDHWRWKIREKHKVENNLLSTYKYILNFHYHMVHPYIRSTKGGPNRVMNSVCVEHSPCEHGNLFCECIYCWEHDGQCRGRKLDLGASTGIERRLANDNQQPGLSDLYCTETIHLATAIPERRTIDRENYVKDFAGQTVGDLYPQLQGSTGASEPIDFAFPTVGSGSWEILVRESHKHFEPNYTEEAYQSHIRSVRRRLFPEETMDNNGSQASTTEMLRDAVQRCGFEGPPNSPSENNRDGIDGTCISTVDIQSNCIVNAHCPKQGTSNQTNKRKKSTDTTESSGSKKNKSSNYQQNLQEQGSTSISDTIDIVDGELDGSTGSNRETAYYTFVLHKNNVKEDWRYIATTRAKQAPSFITFDHGDHIHILFSSSNTGGNSTRVRTRITKFLSATSAGSAEATITFSKVKFLRNYILYCIRYGIETVNIYGNKIQQQLTEAMDTFKILFENRDPNDVILEAGCKLYHEEKKDNKQKRCGQRKQQNLTDIILEKIKEKKITTAQQWENQIEPEFKIQLMKEFGLNVDSYVTRIVRIERTRIQQLIKAKTLTEIMLEILNDEYIKHFTPGEDNSKTAKCIEWIEYLFKENNINIIHFLAWNEIIKTKRYKKINGMVLEGITNAGKSLILDNLLAMVKPEEIPRERDNSGFHLDQVPGAGSILFEEPMITPVNVGTWKLLLEGKTIKTDVKNKDKEPIERTPTWITTATPITNNIDMNETSQILQRIKLYILKKSIQHRDDKYTINAQIQNKLISRPPTLIEPIHMAIVFIKNFTKIYNLIAEEDKAHTVNEKAIQINNEVKEEAESWQTALQWTMTENNEEQNENETQALEDQVLELAKEQATT
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).
What are the official names of this protein?
Initiator protein NS1, NS1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: STRP_STRS1
Sequence: MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDISLKFFEIDLTSRPAHGGKTEQGLSPKSKLFATDSGAMPHKLEKADLLKAIQEQLIANVHSNDDYFEVIDFASDATITDRNGKVYFADKDGSVTLPIQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPALKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYRINKKSGLNEEINNTDLISEKYYVLKKGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK
What is the function of this protein?
This protein is not a protease, but it activates plasminogen by complexing with it.  As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.
What are the official names of this protein?
Streptokinase G.
Protein: MURA_AQUAE
Sequence: MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAELEFLNNTVFINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKRRVHFKFDLVTVTGTENALLYLASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRIEAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDIETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYVEGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYHLDRGYEKLEEKLKKLGADIERVSEL
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN599_HUMAN
Sequence: MAAPALALVSFEDVVVTFTGEEWGHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAGEKAKPKITEPTASQLAFSEESSFQELLAQRSSRDSRLGQARDEEKLIKIQEGNLRPGTNPHKEICPEKLSYKHDDLEPDDSLGLRVLQERVTPQDALHECDSQGPGKDPMTDARNNPYTCTECGKGFSKKWALVRHQQIHAGVKPYECNECGKACRYMADVIRHMRLHTGEKPYKCIECGKAFKRRFHLTEHQRIHTGDKPYECKECGKAFTHRSSFIQHNMTHTREKPFLCKECGKAFYYSSSFAQHMRIHTGKKLYECGECGKAFTHRSTFIQHNVTHTGEKPFLCKECGKTFCLNSSFTQHMRIHTGEKPYECGECGKAFTHRSTFIRHKRTHTGEKPFECKECGKAFCDSSSLIQHMRIHTGEKPYECSECGKAFTHHSVFIRHNRTHSGQKPLECKECAKAFYYSSSFTRHMRIHTGEKPYVCRECGKAFTQPANFVRHNRIHTGEKPFECKECEKAFCDNFALTQHMRTHTGEKPFECNECGKTFSHSSSFTHHRKIHTRV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 599.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYFA_RHIME
Sequence: MSELETLERTLLAEIDAAADEGAIEAVRVGALGKKGSISELLKTLGSMSPEERQTRGARINALKNTVTEAISARKTALKDAAIAERLARETVDISLPVRSSPAERGRIHPISQIVDEITAIFGDMGFSIAEGPDIETDYYNFTALNFPEGHPAREMHDTFFFAPDEKGERKVLRTHTSPVQIRTMEAGQPPIRIIIPGKTYRQDSDATHSPMFHQVEGLVIDRTANVANMRWVLEEFCKAFFEVDQVTMRFRPSFFPFTEPSFEVDIQCDRSGPIVKFGEGKDWMEILGCGMVHPNVLRAGGLDPDEYQGFAWGMGLDRIAMLKYGMPDLRDFFNADVRWMTHYGFRPLDMPTLFGGLSA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_ANAMF
Sequence: MFTNGASVPLSGSKDMENQQHQVLEQELWQGYKDRGFVVTKFSDLVDSVVRWSRSGSLWPMTFGLACCAVEMMHTAASRYDLDRYGVMFRASPRQADVMIVAGTLTNKMAPALRRVYDQMAEPKYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILCLQQKIIRGNPGVRGA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MRGA7_MOUSE
Sequence: MDETSPRSIDIESLIPNLMIIIFGLVGLTGNAIVLWLLGFCLHRNAFLVYILNLALADFLFLLCHFINSAMFLLKVPIPNGIFVYCFYTIKMVLYITGLSMLSAISTERCLSVLCPIWYHCRRPEHTSTVMCAVIWIFSVLICILKEYFCDFFGTKLGNYYVCQASNFFMGAYLMFLFVVLCLSTLALLARLFCGAEKMKFTRLFVTIMLTILVFLLCGLPWGFFWFLLIWIKGGFSVLDYRLYLASIVLTVVNSCANPIIYFFVGSFRHRLKHQTLKMVLQSALQDTPETHENMVEMSRIKAEQ
What is the function of this protein?
Orphan receptor.  May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo.  May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
What are the official names of this protein?
Mas-related G-protein coupled receptor member A7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX3_EUDRU
Sequence: MTRQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHFNSTILLMLGLTTNMLTMYQWWRDVIRESTFQGHHTPNVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMLQALFITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AP180_RAT
Sequence: MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMVPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVADEVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATASAAAPVSSAKPSSDLLDLQPDFSGARAGAAAPVPPPTGGATAWGDLLGEDSLAALSSVPSEAPISDPFAPEPSPPTTTTEPASASASATTAVTAATTEVDLFGDAFAASPGEAPAASEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTASTAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLFDSAPEVAAASKPDVAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSGSGFHCAEDDRHVPLFFTAVDAFAAPSPASTASPAKAESSGVIDLFGDAFGSSASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSGDLLMPTMAPSGQPAPVSMVPPSPAMSASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPTSSVPPGAGAPSVGQPGAGYGMPPAGTGMTMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL
What is the function of this protein?
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.  Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
What are the official names of this protein?
Clathrin coat assembly protein AP180, 91 kDa synaptosomal-associated protein, Clathrin coat-associated protein AP180.
What is the protein family that this protein belongs to?
Belongs to the PICALM/SNAP91 family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Protein: UCSC_ACRSP
Sequence: MYPFFTYSPGRHYFEYKWYNLELLRLIGSAPYGGCDAAEFLELVASLKPNDADEWHHKFLALAERTQAKGEQMSEAGHEAVARGAYLRASNYFRCAQYMFPIMPAARQGEFLKLYHRSIRSFEQAAELMEHRVERVSIPFQPPEYRAPAVELPGWLHLPAAHQRLSGRKTPLLICVGGADSTQEELYFLSAAEGPGLGYAILTFDGPGQGLTLRESGVPLRPDGEVVIEAVLDFIESYAAEHPEADLDVDAISITGQSLGGYLALRGAADPRIKACVAVDPIYDFYDLAMSRMPRWFMWPWERNYMGDGFVDFAVIEHSKLDVATKYTFAQGGQMFGSASPAQMIRDMKQYTFRLDKTITASKRHGNNRDYLEWVTCPVFVTGAAGDEKLFLPEMSTSAIMRNLANVPDEHKELWIPKEWSEGGAQAKSGAWPLLQHRCFKFLDEKLGISRGAKPVQLKTGFVKGVNGHGLTNGGLNGALNGATNGITNGVH
What is the function of this protein?
Alpha/beta hydrolase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Alpha/beta hydrolase ucsC, UCS1025A pyrrolizidinone biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.