PharMolix/UniProtQA huggingface dataset:
Protein: CAIE_ECOL6
Sequence: MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHAALHETQPLRQMEENRPRLQGTTDVTPKR
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: Y2231_RHOE4
Sequence: MRPPAGLPSLSRRSRILLVVAVVVAALLLVGPRLIGMYTDWLWFGEVGYRGVFTKVLLTRFVLFLVVGIVVGAIVWLAMLLAYRARPVFVPVSGPNDPIARYRTTVMSRLRLFGVIIPVAIGILSGLIAQANWVTIQLFLNGQPFGITDPQFNLDVGFYTFDLPFYRFVLNWLFVSILLAFVANLVTHYVFGGIKLAGRAGTFTTAARVQLAVIAGTFVLLKAVAYWFDRYSLMSSSRKEPTFTGPGFTDINAVLPAKLILLSIAVICALAFFASIFTRDLRIPAMAVALLVLSSVLVGAVYPMIVEQFSVKPNAAQKESTYIERNIEATRQAYGITEENVDYVDYPGVGTKQPQDVPADRTTIANTRLLDPTILSPTFTAQRQLKNFYGFPQTLNVDRYEQDGQLRDFVVAARELSPNNLSGNQTDWINKHTVYTHGNGFVAAQANEVTAVQGDSQNNTGGYPIYSVSDLTTTPENENLKVDNPRSYYGEVISQSDADYSIVGSVDGEGPREYDTDTSKYTYTGSGGVSIGNWFNRLAFAAKYTERNILFSSAIGSNSKIIFKRDPKERVEEVAPWLTTDGAAYPAVVDGKMQWIIDGYTTAQDYPYAQRSSLDGLVEDSIDQTTGRLIPRQEFSYIRNSVKATVDAYDGTVTLYQVDEQDPVLKAWMGVFPNTVKPKSEISDDLQAHFRYPEDMFKVQREMLAKYHVDDPSEFFTNNAFWSVPSDPTIDTSANQPPYYVLVGDKDTAKADFRLTSPMVGFSRELLSAYISVANDKENYGKFTVLQLPTDTQTQGPQQAQSAMTSDSRVASEVSLLKQSNKIQYGNLLTLPIAEGGILYVEPLYSQRNSQNAFPQLARVLVSFSDTNGIRIGYAPTVSEAISQIWPGAGSAATVTQPAPDPDTGAQPETPTTPTAPAPPASSDDVTKALAEVNSAMAALKSAQQSGDFTSYGAALDRLQKAVDAYQALPR
What are the official names of this protein?
UPF0182 protein RER_22310.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CXAT2_CONRT
Sequence: MPKLEMMLLVLLILPLSYFSAAGGQVVQGDLHSDVLARYLQRGDRDARECQVNTPGSRWGKCCLNRMCGPMCCPESHCYCIYHRRRGHGCSC
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Rt20.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin D superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GATB_CHLTR
Sequence: MGIAHTEWESVIGLEVHVELNTESKLFSPARNHFGDEPNTNISPVCTGMPGSLPVLNKDAVRKAVLFGCAVEGDVALFSRFDRKSYFYPDSPRNFQITQYEHPIVRGGCIRAVVEGEEKTFELAQTHLEDDAGMLKHFGDFAGVDYNRAGVPLIEIVSKPCMFSAEDAVAYANALVSILGYIGISDCNMEEGSIRFDVNISVRPRGSRELRNKVEIKNMNSFTFMAQALEAEKRRQIEEYLSYPNEDPKKVVPAATYRWDPEKKKTVLMRLKERAEDYMYFVEPDLPVLQITETYIDEVRQTLPELPHSKYMRYITDFDIAEDLAMILVGDRHTAHFFETATMSCKNYRALSNWITVEFAGRCKARGKTLPFTGILPEWVAQLVNFIDRGVITGKIAKEIADRMVSSFGESPEDILRRHPSLLPMTDDHALRAIVKEVVAQNTASVADYKNGKAKALGFLVGQIMKRTEGKAPPKRVNELLLAAMRDM
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MTNA_LEIMA
Sequence: MMSKPHHATLESIKYTPGSLRLLDQRKLPLETVFDDVLTVEDIWSAIKEMRVRGAPAIAVSAALGIAVATQRKAANGELKSGREVQTFLLTSCDFVMTSRPTAVNLFNCLRDLKAQVDKLDPTKAAAEVAQAFVELAEAVYTNDVAFNEGIMRHGAAHILAAAKAEGRDKVSILTICNTGALATSRYGTALGVVRQLFYDGKLERVYACETRPWNQGARLTVYECVQEDIPCTLICDGAASSLMLNRKIDAVVVGADRICQNGDTANKIGTYNLAVSAKFHGVKLYVAAPTTTLDVKTASGNHVEIEEREPTEITTNLVTKQRVVADGPHLSIWNPVFDITPSELITGGIITEKGVQAPAASAPYYDIASIIAQA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CFA20_XENTR
Sequence: MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEVEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKAKQ
What is the function of this protein?
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (By similarity).  Involved in the regulation of the size and morphology of cilia.  Required for axonemal microtubules polyglutamylation (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 20.
What is the protein family that this protein belongs to?
Belongs to the CFAP20 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme.
Protein: BPT_GLUOX
Sequence: MQHRPQLFYTTAPAPCPYLPDRTERKVLTELAGPDAVALHNRLSQAGFRRSHAIAYAPVCVGCRACTPMRIPAATFAPTRTQKKIRSRHTDLVVNIIPPVPTDEQFRLFEMYQAVRHPDGDMAHMCWRDYAELIANTPVETFLAEFRRPDGTLVCVSLMDRLSDGLSAVYTFYDVNDLTASWGTFSILWLIEETARLGLEHLYLGYYVPGSPKMAYKAAFGPPEVFRDGQWSLLAALSPA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_YEAST
Sequence: MSAPEAQQQKRGGFGGRNRGRPNRRGPRNTEEKGWVPVTKLGRLVKAGKITTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNIKPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQPHSLATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLLQLAGVEDVYTQSNGKTRTLENTLKAAFVAIGNTYGFLTPNLWAEQPLPVSPLDIYSDEASAQKKRF
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102).  uS5 is important for the assembly and function of the 40S ribosomal subunit.  Mutations in this protein affects the control of translational fidelity.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
What are the official names of this protein?
40S ribosomal protein S2, Omnipotent suppressor protein SUP44, RP12, S4, Small ribosomal subunit protein uS5, YS5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: GPSB_STRT1
Sequence: MAKINLTPKKIYEQEFKTSIRGYDKTEVDEFLDDVIKDYTVYIALVKELQEENAKLKAKATSAPASRPAYASATSEPSHATTNIASASNYDILKRISRLEKEVFGKQIVE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: EVG1_MOUSE
Sequence: MASQERVDSVTKGTGFRRCRKQAGYTPGTCELLRVMMKESKLTNFQQRHIMDTMKRGAPLPLQCNPTSSLRGSPSKKAASAIYLPPILATHSHLRPASLCQANGAYSREQFKPQATRDLEKEKRRLQNIFATGKDKEERKKVPHVRQEDPAPELDRFDELVKEIQDRKEFLAAMEALGQGRQYRSIILAEISQKLREMEDIDRRRSKELRKALATT
What are the official names of this protein?
UPF0193 protein EVG1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0193 (EVG1) family.
Protein: YCF4_TOBAC
Sequence: MTWRSEHIWIELITGSRKISNFCWAFILFLGSLGFLLVGTSSYLGRNLISFFPPQQIIFFPQGLVMSFYGIAGLFISSYLWCTISWNVGSGYDRFDRKEGIVCIFRWGFPGKNRRIFLRFLIKDIQSVRIEVKEGISARRVLYMDIRGQGSIPLTRTDENLTPREIEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CYPH_SOLLC
Sequence: MANPKVFFDLTIGGAPAGRVVMELFADTTPKTAENFRALCTGEKGVGKMGKPLHYKGSTFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFNDENFVKKHTGPGILSMANAGPGTNGSQFFICTAKTEWLNGKHVVFGQVVEGMDVIKKAEAVGSSSGRCSKPVVIADCGQL
What is the function of this protein?
PPIases accelerate the folding of proteins (PubMed:1702215).  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:1702215).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase, PPIase, Cyclophilin, Cyclosporin A-binding protein, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_BRUMB
Sequence: MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLKPQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVVLVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDSLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVVLERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELVAHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMTEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGPDMARPFARIGDHDDGAVSPDGRIMGTYLHGVFSADRFRHHFLRALGVEGGQMNYRESVEEALGELAEGLEASLDIDGLFALA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: LIPA_SALPC
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVVTERDALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDAEEPQKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIRAKSPEIKIETLVPDFRGRMDRALDILNATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNAEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPEEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_FRATW
Sequence: MSLENKNIIITAGGTGGHIYPALAIAELLRQNKANVTWVGTPNSMEASIVPEYFNIQFIKSSGVRRKGIIKKITFPLKLAYNTLKSRSLLKKLKADLVIGFGGYVSGPICLAAAQINIPVIIHEQNAKIGLTNRILAKFATTICLAFEIENLHKQFSSKQLAKTKIVGNPVRKDIVALNDKARIYTDSSTLKILVLGGSQGAKAINEIIPKLIQKSNEQGINIKVWHQTGKLSLEETKDAYKDISQNHIKDIAAFIDDMAIAYNWADLVICRAGALTVSECAIAGLPAIFIPLPSAVDDHQFFNAQNIVNNNAGFCLRQQQMTLENLLAIIKPLNQDRSKLEQMSKMAKKTLIKNSSEQILDCVKKILNNK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AAT3_BACSU
Sequence: MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSLGNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVMTVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEAVRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQLIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNRTLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPKSPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDFA
What are the official names of this protein?
Putative aspartate aminotransferase YhdR, AspAT, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFB_SHESA
Sequence: MSTMLIAVILLTLLALFFGVLLGFAALKFKVEGNPIVDELEAILPQTQCGQCGYPGCRPYAEAIANGDKVNKCPPGGTATMEKLANLMGVEPEPLNAEAQSQVKKVAYIREDECIGCTKCIQACPVDAIIGAGKLMHTVLTADCTGCDLCVEPCPVDCIDMIPVGQNLKNWNWRLNAIPVTLIQETPHEEKRG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: RASZ_DICDI
Sequence: MASYKNNNLVRLCIMGDGGVGKTAVTIQFISNHFVYYYDPTIEDSYRKQCVIDDQVYMLDILDTAGQDELTAMRDQWIRSCEGFVLVYSITSRSSFDQVQFFREQIIRVLDRDDVPIMMIGNKSDLDDERQVTYQEGKDLARCLGMSFMEVSAKSRANIEEVFNETVRSVKRREESLLKKDKSKDGKDIKKKNSIIKKLNQKVNNTKTSICKMM
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
Ras-like protein rasZ.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: HEM3_LACE2
Sequence: MHYRIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEIEEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIGTGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEITEYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHAPVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGTDSEAVGHEAARMLGLE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PLP2_ORYSJ
Sequence: MASASSPEGASSSSPEKVKMVTVLSIDGGGVRGIIPATILAFLEKELQKLDGPDARIADYFDVVAGTSTGGLLTAMLTAPNENNRPLFAADELAKFYIEHSPSIFPQKNWVLSKIAGTLRMVSGPKYDGKYLHSLLREKLGDTRLDKALTNVVIPTFDIANLQPTIFSKFELKYKPLKNALLSDISISTSAAPTFFPAHYFETKDDNGQTREFNLVDGGVAANNPTLCAMSQVSKYIILEDKEDCDFFPVKPTEYGKFMVISIGCGSNHDQKYKAKDAAKWGIFNWLIKGSSAPIIDMFTSASADMVDIHLGVLFSALQCEKNYLRIQYDQLTGSAGSIDDCSKENMDNLVKIGEMLLDKNVSRVDLETGHYVDVAGEGTNRDQLAKFAKQLSDERRRRQNEPSN
What is the function of this protein?
Possesses non-specific lipolytic acyl hydrolase (LAH) activity.  Hydrolyzes phospholipids as well as galactolipids.  May play a role in disease resistance (By similarity).
What are the official names of this protein?
Patatin-like protein 2, OsPLP2.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
Protein: PLSY_VIBA3
Sequence: MTPLALIMIIAAYLLGSISSAVLICRLLRLPDPRTVGSNNPGATNVLRVGGKGAAAAVLLCDMLKGTIPVWLGYYLKIDPIILGVVAIAACLGHMYPIFFHFKGGKGVATALGAIAPIGFDLTGMIMATWLVVAFLFRYSSLAALVTVLLAPFYAWLVKPQYTLPVAMLCCLIVLRHHQNIRRLLDGSEPKLGQKKSA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAD1_PONAB
Sequence: MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVRLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Oligosaccharyl transferase subunit DAD1, Defender against cell death 1, DAD-1.
What is the protein family that this protein belongs to?
Belongs to the DAD/OST2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ESR1_MESAU
Sequence: MTMTLHTKASGMALLHQIQGNELEPLSRPQLKMPLERALSEVYVDSSKPAMFNYPEGAAYEFNAATAPAPVYGQTGIAYGSGSEATAFGSNSLGLFPQLNSVSPSPLMLLHPPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDSGPPAFYRSNSDNRRQSGRERLSSSSEKGSMAMESVKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNDMGPSGDMRATNLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLIWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSARFRMMDLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPFYDLLLEMLDAHRLHTPVSRMGVSPEEPSQSQLTTTNSTSSHSLQTYYIPSEAESFPNTI
What is the function of this protein?
Nuclear hormone receptor.  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.  Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components.  Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.  Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.  Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP.  Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences.  Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP.  Can activate the transcriptional activity of TFF1.  Also mediates membrane-initiated estrogen signaling involving various kinase cascades.  Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: HSL63_DICDI
Sequence: MTILSTFTSFSNPPKLNKSSFSSSTGSSLSMGSNSFAWGGGWGGFGGPKGGSFNVDIAGNLIWGVYGFIRGGVGLVKWRGLQKGCKQP
What is the function of this protein?
Chaperone that suppresses aggregation of proteins with long polyglutamine (polyQ) tracts (PubMed:30029002).  Acts by promoting degradation of polyQ aggregates by the proteasome (PubMed:30029002).
What are the official names of this protein?
serine-rich chaperone protein 1, HssA/B-like protein 63.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: LPXK_WIGBR
Sequence: MRKSTVYSWINKKKYILKINVISIINYIWFKKTIMRFFLYPFSLIYFLVIKIIYILYKCNFKKTYNFNIPIIVIGNITVGGNGKTPLVIWLSKQLKKRKWKVGVVSRGYGRKYDFPIIINSNFTHDICGDEPILIHKRSNVPVAVSSNRILAIKMLLEYYNLDIIISDDGLQHHSMGRCIEWIVIDNNRKFGNNLLLPAGPMRETKKKLNKVNKVIINGCCRNKNIIKMNLYHKNYVINLLNGSKKRLNDLFPTILISGISNNKNFFSMVRKSGIIPIREISFPDHYIYDKNILTSLTKNNEHLLMTEKDSIKCKYFAKINWWYLPIYVFFSKKCKEVLLSSVEKKIIIFKFKNKKNNIFNKI
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: COBU_SALTY
Sequence: MMILVTGGARSGKSRHAEALIGDAPQVLYIATSQILDDEMAARIQHHKDGRPAHWRTAECWRHLDTLITADLAPDDAILLECITTMVTNLLFALGGENDPEQWDYAAMERAIDDEIQILIAACQRCPAKVVLVTNEVGMGIVPENRLARHFRDIAGRVNQRLAAAADEVWLVVSGIGVKIK
What is the function of this protein?
Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
What are the official names of this protein?
Bifunctional adenosylcobalamin biosynthesis protein CobU, Adenosylcobinamide kinase, Adenosylcobinamide-phosphate guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobU/CobP family.