PharMolix/UniProtQA huggingface dataset:
Protein: TTCA_PSEU2
Sequence: MGTLSVNQNKLQKRLRRLAGEAVADFNMIEEGDKVMVCLSGGKDSYTMLDVLMHLQKVAPIKFDIVAVNMDQKQPGFPEHVLPAYLKELGIEYHIVEKDTYSVVKELIPEGKTTCSLCSRLRRGTLYTFADEIGATKMALGHHRDDIVETFFLNMFFNGSLKAMPPKLRADDGRNVVIRPLAYCHEKDIQAYSDLKQFPIIPCNLCGSQENLQRQVVKEMLQDWERKTPGRTESIFRALQNVQPSQLADRNLFDFTNLRIDETAASRFVNVVNI
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARR6_ARATH
Sequence: MAEVMLPRKMEILNHSSKFGSPDPLHVLAVDDSHVDRKFIERLLRVSSCKVTVVDSATRALQYLGLDVEEKSVGFEDLKVNLIMTDYSMPGMTGYELLKKIKESSAFREVPVVIMSSENILPRIDRCLEEGAEDFLLKPVKLSDVKRLRDSLMKVEDLSFTKSIQKRELETENVYPVHSQLKRAKI
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ARR6.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YDFG_SHIFL
Sequence: MIVLVTGATAGFGECITRRFIQQGHKVIATGRRQERLQELTDELGDNLYIAQLDVRNRAAIEEMLASLPAEWSNIDILVNNAGLALGMEPAHKASVEDWETMIDTNNKGLVYMTRAVLPGMVERNHGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTTVRVTDIEPGLVGGTEFSNVRFKGDDGKAEKTYQNTVALTPEDVSEAVWWVSTLPAHVNINTLEMMPVTQSYAGLNVHRQ
What is the function of this protein?
NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids.  Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone.  Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate.  Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid.  YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde.
What are the official names of this protein?
NADP-dependent 3-hydroxy acid dehydrogenase YdfG, L-allo-threonine dehydrogenase, Malonic semialdehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PYRE_THETH
Sequence: MDVLELYRRTGALLEGHFLLRSGMHSPFFLQSAALLQHPLYAEAVGEALGKLFEDEKVDFVIAPAIGGVVLSFVVAKALGARALFAEKDGRGGMLIRKGLTVNPGDRFLAVEDVVTTGESVRKAIRAAEARGGVLVGVGAIVDRSGGRAAFGVPFRALLALEVPQYPEEACPLCREGVPLEEV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SYS_LEPBL
Sequence: MLDLHYITENTEDLKKVLELRGFKEVGIIDELKSIIQRKRELQREVDLLREERNKVSKEVGRIKQSGGDITEISASVKLVGEKIKEIETKLEQEENVLININLGLPNILDPKVPNGKSEYDNVVQYEVGKIPSFSFPPKPHFEIGEALNWINFEKGVKLSGARAYTYWKDGAKLERALMNFMLDVHTKEHGYTEVWVPSMVNDESMTATGQYPKFKDEFYRIEKDELNLIPTAEVPLTNLYRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEHKKMLSHAENILKKLKLPYRVIILCSGDISANSSITYDIEVWMPGLNRFMEISSVSNFRDFQARRGKIRYKSKDGKNQLVHTINGSGLAIGRTYAAILENFQDANGTVHIPEVLKSYF
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CML32_ORYSJ
Sequence: MDAKQSVAAAKPSLAKKTASASFRLRNGSLNAVRLRRVFDLFDRNGDGEITVDELAQALDALGLVADRDGLAATVSAYVPEGAAGLRFEDFDALHRALGDALFGSLDGAAAAGEPGGGGGDEEEEMREAFKVFDVDGDGFISASELQEVLKKLGLPEAGSLATVREMICNVDRNSDGRVDFGEFKSMMQGITVWGP
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML32, Calmodulin-like protein 32.
Protein: RL5_BRUC2
Sequence: MAEAKALPRFKKLYQDNIRKALLEEFKYDNEMQIPRITKVVLNMGVGEATGDSKKPAVAAEDLAMIAGQKAVVTRARNSIATFKLREGMPIGAKVTLRQDRMYEFLDRLITIALPRVRDFRGLNPKSFDGRGNYAMGIKEHIVFPEINYDKVDQIWGMDIIVCTTAKTDDEARSLLRAFNFPFRQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: SYM_NEIMA
Sequence: MTRKILVTSALPYANGSIHLGHMVEHIQTDVWVRFQKLRGNECHYCCADDTHGTPVMLAAQKQGIAPEDMIAKVREEHLADFTGFFIGYDNYYSTHSPENKQFSQDIYRALKANGKIESRVIEQLFDPEKQMFLPDRFVKGECPKCHAQDQYGDNCEVCGTTYSPTELINPYSAVSGAKPELRESEHFFFKLGECADFLKAWTSGNNPHDGKPHLQAEALNKMKEWLGEGEETTLSDWDISRDAPYFGFEIPDAPGKYFYVWLDAPVGYMASFKNLCDRIGVDFDEYFKADSQTEMYHFIGKDILYFHALFWPAMLHFSGHRAPTGVYAHGFLTVDGQKMSKSRGTFITAKSYLEQGLNPEWMRYYIAAKLNSKIEDIDLNLQDFISRVNSDLVGKYVNIAARASGFIAKRFEGRLKDVADSELLAKLTAQSEAIAECYESREYARALRDIMALADIVNEYVDANKPWELAKQEGQDARLHEVCSELINAFTMLTAYLAPVLPQTAANAAKFLNLEAITWANTRETLGKHAINKYEHLMQRVEQKQVDDLIEANKQSIQTTPAPAAEESQYEKVAEQASFDDFMKIDMRVAKVLNCEAVEGSTKLLKFDLDFGFEKRIIFSGIAASYPNPAELNGRMVIAVANFAPRKMAKFGVSEGMILSAATADGKLKLLDVDAGAQPGDKVG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQNA_STRCO
Sequence: MDNSRTRPRVGHIQFLNCLPLYWGLARTGTLLDFELTKDTPEKLSEQLVRGDLDIGPVTLVEFLKNADDLVAFPDIAVGCDGPVMSCVIVSQVPLDRLDGARVALGSTSRTSVRLAQLLLSERFGVQPDYYTCPPDLSLMMQEADAAVLIGDAALRANMIDGPRYGLDVHDLGALWKEWTGLPFVFAVWAARRDYAEREPVITRKVHEAFLASRNLSLEEVEKVAEQAARWEAFDEDTLAKYFTTLDFRFGAPQLEAVTEFARRVGPTTGFPADVKVELLKP
What is the function of this protein?
Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
What are the official names of this protein?
Chorismate dehydratase, Menaquinone biosynthetic enzyme MqnA.
What is the protein family that this protein belongs to?
Belongs to the MqnA/MqnD family. MqnA subfamily.
Protein: APT_BURMS
Sequence: MSSDRRTARDCSAVFFGEFHDVHVGRAARSRRVHSQPHPHGAGLAAARRDVSRHHAALQSAKALRVLVDLFVERYVDAKLDYIAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLGAVVVEGAAIVDLPDLGGSALLREAGLPLYTVTEFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_VIBC3
Sequence: MFNFANVYQQIAQHPQLQLWLNTLPQQLTDWQAKQHGDLDRWMRNLKKIPVGQPEVIDLKNAVAAHNHQPLAQGEQKKLEAVLKTFHPWRKGPYHLHGIHIDTEWRSDWKWDRLLPHISPLKNRLVLDVGCGNGYHMWRMLGEGAQQVFGIDPSELFLIQFEAVRKLLGDDQRVHLLPLGIEQMPELNAFDTVFSMGVLYHRRSPLDHLLQLKNQLVAGGELILETLVVEGDEHTVLVPFDRYAQMRNVYFFPSALALKVWLEKTGFVDVRIVDENITSLGEQRTTEWMTHNSLPDYVDPQDPSKTIEGYPAPRRAILIAKKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: PKHF1_MOUSE
Sequence: MVDHLANTEINSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLSKRKYRSQHIIPLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECVRRQLLATGRQPTTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPRLSPKPLRVCSLCYRELAAQKLREEAREGIGGSPPQLSHLGGTVCGASSGDDDDSDEDREGNGDGDWPTQVEFYASGVSWSAFHS
What is the function of this protein?
May induce apoptosis through the lysosomal-mitochondrial pathway.  Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm.  Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family F member 1, PH domain-containing family F member 1, Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.
Protein: CM3F_CONMR
Sequence: MLKMGVVLFIVLVLFPLATLQLDADKPVERYAENKQLLNPDERRGIILHALGQRVCCPFGGCHELCLCCDG
What is the function of this protein?
Intracranially injection into mice does not elicit symptoms.
What are the official names of this protein?
Conotoxin mr3f, Conotoxin Mr3.9.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL28A_MYCTO
Sequence: MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSEDRRIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL
What are the official names of this protein?
50S ribosomal protein L28-1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TTTP_BPLP2
Sequence: MAMNLLNTASIAKEMQTKVTERMGDWFEAEFKAKANSASRRTRLIRSHGHTYTYARYQNTGQLSSNLKQVKKGDKIVIDAGTRANYTSGYHGMYFLVEKKGMQEVKTTLKKGANYANSMKL
What is the function of this protein?
Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the connector and the tail tube proteins.
What are the official names of this protein?
Probable tail terminator protein, Gene product 10, gp10.
What is the protein family that this protein belongs to?
Belongs to the Skunalikevirus tail terminator protein family.
What are the subcellular locations of this protein?
Virion. Note=Located at the interface with the connector and the tail tube.
Protein: URAA_PASMU
Sequence: MTNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLCTGRQVPIFLASSFAFIAPIQYGVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKVFPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFVSMATLLTTLGVAVFAKGMMKLIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVEHVGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNFNPKIMTWAAVWAIAISFCGKVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAILLNLILPKAKNTPIEENR
What is the function of this protein?
Transport of uracil in the cell.
What are the official names of this protein?
Probable uracil permease, Uracil transporter, Uracil/H(+) symporter UraA.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RANL_DROME
Sequence: MQPQEEVKAIFKLILIGDGGTGKTTLVKRHLTGEFKMQYNATLGVEVEQLLFNTNRGVFRIDVWDTAGQERYGGLRDGYFVQSQCAIIMFDVASSNTYNNVKRWHRDLVRVCGNIPIVICGNKVDIMHKKTWKKGVDFDRKTNIYLIEMSAKSNYNVEKPFVYLLRKLVGDPSLQLVQSPAIQPPKVVFTDEMSRQVESLFNEAKSKPLPTIYDIDL
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.
What are the official names of this protein?
GTP-binding nuclear protein Ran-like.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPG_WOLPP
Sequence: MLDRDLTLSDDAYESSPVSRHKTHTVKVGQVKIGGNNPIVVQSMALGAHIDSDNIKSSAQKYAKEVIELAHAGSELVRIALNSEEVAKAIPYIVEEINKEGFDGKILVGCGQYELYRLIQDYPDNIKILGKIRINPGNIGFGDKRDEKFEKIIEYAITHDLPVRIGVNWGSLDKYLSQKLMDENSLSSNPKTSDVILRKTLVMSALGSAKKAEKIGLNAEKIIISCKVSRVQDLILVYTALAKSSNYALHLGLTEAGMGNKGVVNTTAGLTYLLQNGIGDTIRASLTQRPGESRTNEVVVCQEILQSIGLCYFNPQVSSCPGCGRTSSDRFRILTEEVNGYIKTHMPVWKKKNPGVEYMKVAVMGCIVNGPGESKHANLGISLPGYGEKPVSAVYKDGKYFKTLQGDNIFEEFKEIISDYVEKHYT
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RL7_AZOVD
Sequence: MALTNEDIINAVSEMSVMQIVELIKAMEEKFGVTAAAAVAAGPAAAAPVAEEQTEFTVVLAEAGDKKVNVIKVVRELTGLGLKEAKAVVDGAPGVVKEGISKDEAEAAKKALEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y257_ABVP
Sequence: MGEQVLDFRGLFDERGNPITKRKKAVEQVEEVVTPEEKTKVVTVEKPVYIPVEKRKLKRKITFAPEDSLSTDDVFAPRVYYDYNFSPFDFLSRSRTFAPRMSYDYEYAPEDFSSYSEVYSPSESYDDTFAPKYRNFRKSVYSPSTVIKNKFAPKVTQRIKFKPRLFDKLLAIFAPESILKTKENVKYKPYNYQYQETAIIDTYNPEQITTVEKFSPKDESNFNLRIAPETDFSIKLSPPPISFTSVDYYGILKKIIR
What are the official names of this protein?
Uncharacterized protein ORF257.
Protein: SPNS1_ARATH
Sequence: MTRVGQRDSPAKEEAPPATKKRFLTPGRFVTILCIINLINYVDRGVIASNGVNGSSKVCDAKGVCSAGTGIQGEFNLTNFEDGLLSSAFMVGLLVASPIFAGLSKRFNPFKLIGVGLTVWTIAVIGCGFSYNFWMIAVFRMFVGVGEASFISLAAPYIDDSAPVARKNFWLGLFYMCIPAGVALGYVFGGYIGNHLGWRWAFYIEAIAMAVFVILSFCIKPPQQLKGFADKDSKKPSTSIETVAPTDAEASQIKTKTPKSKNLVVLFGKDLKALFSEKVFIVNVLGYITYNFVIGAYSYWGPKAGFGIYKMKNADMIFGGLTIICGIIGTLGGSYVLDRINATLSNTFKLLAASTLLGAAFCFTAFLMKNMYAFIALFAVGEILIFAPQAPVNFVCLHCVRPNLRPLSMASSTVLIHILGDVPSSPLYGKMQDHLKNWRKSTLIITSILFLAAIIWGIGIFMNSVDRSNEVSEDDEVEEDKLESKTENSTLA
What is the function of this protein?
Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage.
What are the official names of this protein?
Probable sphingolipid transporter spinster homolog 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: ENO_SALTO
Sequence: MATIEGIVAREILDSRGNPTVEVEVGLDDGTIARAAVPSGASTGAFEAVELRDGEKDRYLGKGVTQAVSNIEDKIVDELIGYEASEQRLIDQKMLDLDGTDNKSQLGANAILGVSLAVAKAAASAAELNLFRYLGGPNAHLLPVPMMNILNGGAHADSNVDIQEFMIAPIGAPTFREALRSGAEVYHALKSVLKKKDLATGLGDEGGFAPNLPTNAAALDLISEAVEKAGYRLGTDIVFALDVAATEFFENGTYTFEGVEKTAEEMSSYYTKLADAYPIVSIEDPLAEDDWSGWRTLTASVGDRIQIVGDDLFVTNPQRIARGIAENAANSVLVKVNQIGSLTETLDAVDLAHRAGFRCMMSHRSGETEDTTIADLAVATGCGQIKTGAPARSDRVAKYNQLLRIEEELADAARYAGSGAFPRYRSA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL4_IDILO
Sequence: MELTLKDAKGALEVSEATFGREFNEALVHQVVVAYAAGARQGTKAQKTRSEVAGGGKKPWRQKGTGRARAGTIRSPIWRSGGATFAAKPQNHSQKVNKKMYRGAIKSILSELIRQERLIVVEKFGVDEPKTKQLAAKLKEMDLNDVLIVTKEVDENLFLASRNLHKVDVRDVQGIDPVSLIAFEKVLMTADAVKQLEEVLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: SUCC_BACMK
Sequence: MNIHEYQGKAVLRSYGVSVPNGKVAFTVEEAVEAAKELGTEVCVVKAQIHAGGRGKAGGVKVAKNLEEVRTYAESILGTTLVTHQTGPEGKEVKRLLIEEGCDIKKEYYVGLVLDRATSQVVLMASEEGGTEIEEVAEKTPEKIFKEYIDPAVGLQGFQARRIAFNINIPKELVGQAVKFMMGLYSAFIEKDCSIAEINPLVTTGDGKVMALDAKLNFDSNALYRNKDILELRDLEEEDSKEIEASKYDLNYIPLDGNIGCMVNGAGLAMATMDIIKHYHGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFGGIMKCDVIAEGVIEATKQVGLELPLVVRLEGTNVELGKKILNESGLNIVAAESMADGAQKIVSLVG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RNFE_HAEIN
Sequence: MTDLTEKNTALEEEKIESAVENQQKSIWKEIFAQGIWKNNPAVVQLLGLCPLLAVSSTATNALGLGLATMLVLTCTNTVISLFRQYIPKEIRIPIYVMIIATTVTAVQLLMNAYTYTLYQSLGIFIPLIVTNCIIIGRAEAFASKNSLLHSIWDGFSMGLGMALSLTILGALREIIGQGTIFEGIENLFGEQAKFLTHHIYHTDSSFLLFILPPGAFIGLGLLLAIKNRIDNIKK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSCL_YERP3
Sequence: MSFMKEFREFAMRGNVVDLAVGVIIGAAFGRIVSSLVADIIMPPLGLLLGGVDFKQFHFVLRAAEGTIPAVVMNYGTFIQSIFDFVIVALAIFSAVKLMNKLRREKAEEEPATPPAPTTEEILLAEIRDLLKAQHTK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LOLD_BORPA
Sequence: MTEPNDTGPALQAEHLGKVYDEGPARIEVLSDVSLSVARGEMVAIVGASGSGKSTLLHILGLLDVPSSGTVSVDGVPAAGLSEKRKSALRNRSLGFVYQFHHLLPEFSALDNVAMPLIVRRENRDRARAQAREVLELVGLAAREEHFPGQLSGGERQRVALARALVTRPACVLADEPTGNLDRHTAHNMFELLTRVNRESGTAFVIVTHDPELAARADRQLHMENGRLQPD
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MINC_ACIAD
Sequence: MADIRITGRMVNFTRLTFDTNDHDAIRQQLTSILNEGSYQGTVVILDSTVEQELIALIQLLISLGLQPMAVIDGILSDEAKAIQFPVLPADQPLQRIKASKEEITVIATPKAADTTPETKTPITKTAIAHKTSYHDEILRTGQCLVQDHGDIILNAGMNSGSEVIASGNIHIYGNVRGRIIAGAGGNPSARIFCHALEAELVSIAGTYCVAEDIPKDVLKKSVHIYLNDNQELEFRALEF
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RN5A_HUMAN
Sequence: MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC
What is the function of this protein?
Endoribonuclease that functions in the interferon (IFN) antiviral response.  In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes.  RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.  Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances.  In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979).  Might play a central role in the regulation of mRNA turnover (PubMed:11585831).  Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
What are the official names of this protein?
2-5A-dependent ribonuclease, 2-5A-dependent RNase, Ribonuclease 4, Ribonuclease L, RNase L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.