PharMolix/UniProtQA huggingface dataset:
Protein: CVC1_EHV2
Sequence: MDVHLGNWRLCGRRCGRLAHVVLPEAFLDRHGLAEDAGAEFFVQTRFTGSLRPSSYVRVIGAFFGGGSGDEIARRDRRSALNLVLSLPLLADGDGRYDPHNIATLKVRSGDGRRLVFVDFFYLSLLGAQMPRGPESEGEGGKDGGAGRGDGEASRESPLERIAAEASGPGPGSGRGRSAGGRRASPLSVLSGLLDNKYTQIAKHHRALEDPGAVRGVNIEPDRRDHGNLAGVGKRKVRCALNLIDLKRDDITFTSSTHLLSGTRFTLCHYPRPVAPPGGAPWESTLDGLSERQLRGVDPLAALILGFDFLERAQTGLVNSLARECENGGLKIFQRLPVCVEKKHDIRGVLGDHFTEACHVLARQVGESCAWVRACVSGERGHVGLWADFLNLWEAGPSTLGVDLSYLFSPGPPDDESAFWARLLGSDRLLDAIKTGARAVLVVDSQLAAWLLLPGGFAIKGRYSLSREDIQITVGRYG
What is the function of this protein?
Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes.
What are the official names of this protein?
Capsid vertex component 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae CVC1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RL28_BORT9
Sequence: MGRECEITGKKTMFGNNVPRKGLSRKKGGGGQHIGVKTRRTFKVNLINKKFFVPELGKSINIKVSASTLRSISKLGLSVFLKKNSKKIEDFI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CXCR2_PANTR
Sequence: FNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
What is the function of this protein?
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor.  Binding of IL-8 to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.  Binds to IL-8 with high affinity.  Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
What are the official names of this protein?
C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, High affinity interleukin-8 receptor B, IL-8R B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL2_THISH
Sequence: MPIVKSKPTSAGRRFVVSVVSPDLHKGEPYAPLVEKKVRSGGRNNQGRITTRHVGGGHKQRYRIIDFKRDKDGIPGRVERLEYDPNRSAHIALVLYADGERRYVIAPKGVQAGDQLLSGTNAPIRAGNTLPLRNIPVGTVVHCIEMKPGKGAQMARSAGAAVQLVAREGQHATLRLRSGEMRKVPADCRATIGEVSNSEHSLRKFGKAGAKRWLGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVPTKGYKTRKNKRTDNMIVRRRNKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MAZE_STAA1
Sequence: MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity.
What are the official names of this protein?
Antitoxin MazE.
What is the protein family that this protein belongs to?
Belongs to the MazE/EndoAI family.
Protein: ASTD_ECOLU
Sequence: MTLWINGDWVTGQGALRVKRNPVSGEVLWQGNDADAAQVGQACRAARAAFPRWARLSFGDRQVRVERFAGLLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHIRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGKWDDEPQPFIGGLISDQAAQQVVTAWQQLEAMGGRPLLAPCLLQAGTSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDNFDEAIRMANNTRFGLSCGLVSPAREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: GCSH_SALAR
Sequence: MSNVPAELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVKAASDIYAPVSGEIVAVNDALSDSPELVNSEPYADGWIFKIKASNESELESLLDATAYEALLEDE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: Y763_ARCFU
Sequence: MDNQAKLSLDLLLGLSIFLTTFLFVANFLPGIFADVRHEIALGSHAYRVAALLVEDPGYPDDWCTAVDTSNCISKEFRPGLAIFDENNGTEYNYLNTSKIFKLQELLSNSACRDTVRNYLGLNSTNFKYKFYFSLKYLNDTEIVSGGDNLPEMGNIIKFDRLVYVDNCTAIPCESIAERCVCKLEVAVWI
What are the official names of this protein?
Uncharacterized protein AF_0763.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACP_PROM9
Sequence: MSQEILEKVCSIVSEQLSVEAAEVKSDSNFQNDLGADSLDTVELVMALEEAFDIEIPDEAAEGIATVGDAVKFIEEKKG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_ONYPE
Sequence: MNIEQLKERQKRIRNFSIIAHIDHGKSTLADRILEFTGTIDKRIMKEQILDSMDLERERGITIKLNAVEINYKSKDGKNYIMHLIDTPGHVDFSYEVSRSLAACEGAILIIDAAQGIQAQTLANVYLAVDNNLTLIPVLNKVDLPSADVPKVKEEIKETLGLDPEQALIASGKTGLGVIDILEQIVTRISPPQGDIQKPLQALIFDSYFDSYKGVVPSIRIVNGTVKKGDQIRFMASNSVYEVVEVGVYNPKQIVKDFLAPGDVGYLTAAIKSINHVRVGDTITSQTNQALLPLPGYKQMNSVVFCGLYPVETNKYDILKEALEKLKLNDSSLIFEPESSNALGLGFRTGFLGLLHMEIIQERISREFGVEVIATAPSVIYHVYSIKGEKLLVDNPSKLPSTQMIDRIEEPFIKATIMCPEIYIGKVMELSQNKRGALQNIEYIDSQRVMINYLLPFSEIIYSYFDKLKSLTKGYASFDYEIDKYRVSKLQKMDILLNGEIVDALSLIVHHDFAYERGKAICETLKEFIPKQMFEIPIQAALGKKIIARQTIKAMRKDVTAKLYGGDVTRKKKLLEKQKKGKKKMKTLGKVQLPQKAFLAILATK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSBM_THEVL
Sequence: MEVNQLGFIATALFVLVPSVFLIILYVQTESQQKSS
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation (PubMed:19433803, PubMed:23426624).  This subunit is found at the monomer-monomer interface.  Probably involved in dimerization of PSII; at the monomer-monomer interface the only protein-protein contacts observed are between the 2 PsbM subunits.  Lipids, chlorophylls and carotenoids contribute strongly to PSII dimerization.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS2_CAMC1
Sequence: MVTMRDLLECGVHFGHQTRRWNPKMKKFIFGERKGIYIIDLQKTIRYFRYTYNIVRDAAAEGKSVLFVGTKKQAIDAIKEYAEKCGMPYVNHRWLGGMMTNFGTIRQSIRKLEVIETMEEDGSINLLTKKEALMLRRKKEKLIATLGGIRNMKSLPDMIFVVDTVKEKIAVQEANRLKIPVVAPIDTNCDPDVVDYPIPGNDDAIRSVQLFCQEMAEAINEGKSLLEQDGGEQAAGEEVSQDEKDAVVAEAMSEEDFGEDEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYR_ANAD2
Sequence: MVRDRVIELFRKALAQGADDGRWPAAGAGFSVEAPRDPKHGDFAVNAAMVLAKQAGRPPRELAQAIVEAVRAADTAGDLAGLEIAGPGFINVRLSPDLWLRTLARAVAEGPDYGRTAVGQGKKVIVEYVSANPTGPMHVGHGRNAVVGDGVQGLLRWAGFDVTREYYVNDYGAQVQTLARSVHLRYQELHGRTVTMPPKSYPGEYVKDIAAGLKAEYGARFLDAPEAEWLTLFRDHSVQHVLGMIRGDLAAVNISFDRWSSEKALYESGTVDRFLRFLEEKDLVYVGKLPPPKSKKGQPPPQPQPDEEGVTAAEDLTLFRSSAYGDEVDRPVKKADGTPTYFCADIAYHWDKRQRADALVDVLGADHGGYVPRLEAAMEALGASRKDLHVVLIQMVSLMRGGESVKMSKRAGTLVSLREVVDEVGRDATRFIFLTRRSDAPLDFDVELAKRQTLDNPVFYVQYGHARLAAIFQKAREAGHAVPDFDLEAARTLASPEEQDLIRRIAAFPDMLAAAALAYEPHRVAFYLQETIAAFHSWYTQGKKSGEKVIGPDPVKTAARLFLCRALKQVLANGLAVLGVSAPDRMESPETRDIADDV
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT1A3_OREMO
Sequence: MGDKDDRFPKKKKGGTKDMDALKKEVPITEHKMSVEEVCRKFQTDVVQGLTNAKAAEFLLRDGPNALTPPPTTPEWVKFCRQLFGGFSILLWTGAILCFLAYAIQAATEDEPAGDNLYLGIVLTAVVVITGCFSYFQEAKSSKIMESFKNMVPQQALVIREGEKVQVNAEEVMAGDLIEVKGGDRIPADIRVTSAHGCKVDNSSLTGESEPQSRSPDCTHDNPLETRNIAFFSTNCVEGTARGIVICTGDRTVMGRIATLTSGLETGKTPIAVEIEHFIHIITGVAVFLGVTFFILAIILGYTWLKAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGAAFDKSSVTWLSLSRVAPLCNRAQFKPRQDSVSILKRDVAGDASESALLKCIELSCGSVRMMRDKNKKVAEIPFNPTNKYQLSIHETEDPNDNRYLLVMKGALERILDRCSTIMLQGKEQPMDEEMKEAFQNAYMELGGLGERVLGFRHLLLPEDQYPKGFAFDTDDVNFQTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGSDLKDLSQDQMDDILRNHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFIIVNIPLALGTITILCIDLGTDMGSAISLAYETAESDIMKRQPRNPCRDKLVNERLISIAYGQIGMIQALGGFFSYFVILAENGFLPSQLVGIRLNWDDRSLNDLEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFWAFPYSFLIFVYDEARKLILCRNPGGWVEKETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-3, Na(+)/K(+) ATPase alpha-3 subunit, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GAP22_ARATH
Sequence: MKALRRSYTSTSSGNSSSSSSLPSSSSSSLPSSSSSSPPSSNSNSYSNSNSSSSSSSWIHLRSVLFVANLSSPSSVTSSDRRRKSPWSRRKRKWALTPHQWRSLFTPEGKLRDGGVGFLKKVRSRGVDPSIRAEVWLFLLGVYDLNSTSEEREAVKTQKRKEYEKLQRRCQMLLKCGNGSTDNLEELPSDEANSQCVRFVDDYKITGPMTSQDVVSALNTDSSDTDSCEDNEDVLLLSSFAHSDEKKPEEDNSNNNSEENSSLLVAAASEVQVEVAVHEDFSTWQRIIRLDALRADSEWANYSPYSTAITESKARRLAESVGLKDYDHLESCRLYHAARLVAILEAYAMYDPEIGYCQGMSDLLSPILAVISEDHEAFWCFVGFMKKARHNFRLDEAGIQRQLSIVSKIIKNKDSQLYKHLENLQAEDCSFVYRMVLVMFRRELSFEQTLCLWEVMWADQAAIRAGVGKSPWSRIRQQAPPTDDLLLYAIAALVLRRKLIIQKYSSMDEIVEECNSMAGQLNVWKLLDDAHHLVVTLHDKIETLSQSQSI
What is the function of this protein?
Involved in defense response against fungal and bacterial pathogens (PubMed:24505423).  Acts as negative regulator of jasmonate (JA) responses during infection by the soil-born fungal pathogen Verticillium longisporum (PubMed:24505423).  Involved in abscisic acid-dependent stomata closure in response to infection by V.  longisporum and Pseudomonas syringae (PubMed:24505423).  May be a downstream component of brassinosteroid-mediated signaling (PubMed:24505423).
What are the official names of this protein?
Rab GTPase-activating protein 22.
What are the subcellular locations of this protein?
Nucleus. Peroxisome. Note=Localizes to peroxisome under biotic stress conditions.
Protein: SYS_CHLAA
Sequence: MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIGAMKDPAERQAKIDAMRQLGDEIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDNVVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGSRFYVMRGAGARLQRAVIQWLIDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYADEILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKLRRDAEECARRLGLPFRTKLLCTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQARRANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQEDGSILIPEVLRPYMGGMERIGP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US9_VZVO
Sequence: MAGQNTMEGEAVALLMEAVVTPRAQPNNTTITAIQPSRSAEKCYYSDSENETADEFLRRIGKYQHKIYHRKKFCYITLIIVFVFAMTGAAFALGYITSQFVG
What is the function of this protein?
Essential for the anterograde spread of the infection throughout the host nervous system.  Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
What are the official names of this protein?
Envelope protein US9, Envelope protein 65, ORF65 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae envelope protein US9 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein.
Protein: PYRB_STRP3
Sequence: MSVVNNRVALTNLVSMEALTTEEVLGLINRGSEYKAGKVVISDHQKDLVANLFFENSTRTHKSFEVAEKKLGLTVLDFNADASAVNKGESLYDTVLTMSALGTDICVIRHPEDDYYKELVESPTITASIVNGGDGSGQHPSQCLLDLLTIYEEFGRFEGLKIAIAGDLTHSRVAKSNMQILKRLGAELYFYGPEEWYSEAFNAYGTYIAIDQIIKELDVLMLLRVQHERHDGHQSFSKEGYHQAFGLTQERYQQLKDSAIIMHPAPVNRDVEIADSLVEAPKARIVSQMANGVFVRMAIIEAILNGRNKNS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: REX_STRA1
Sequence: MDKSIPKATAKRLSLYYRIFKRFNTDGIEKASSKQIADALGIDSATVRRDFSYFGELGRRGFGYDVKKLMNFFAEILNDHSTTNVMLVGCGNIGRALLHYRFHDRNKMQISMAFDLDSNDLVGKTTEDGIPVYGISTINDHLIDSDIETAILTVPSTEAQEVADILVKAGIKGILSFSPVHLTLPKDIIVQYVDLTSELQTLLYFMNQQQ
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_BORBU
Sequence: MGLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVKPLTYMNLSGSLFPSIFSDFYMCIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSVLGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKLYDFLSDELIDISEANFKNKVQKINSSNF
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER2_CUCSA
Sequence: TFYDESCPDVSNIVRRVVQQALVSDERAGARLIRLHFHDCFVNGCDGSVLLEDQPGVVSELAAPGNANITGFNIVNNIKAAVEKACPGVVSCADILAIASVGSVNLAGGPCWEVQLGRRDSRRANLQGAIDGLPSPFENVTQLKRKFDRVDLDSTDLVALSGAHTFGKSRCQFFDRRLNVSNPDSTLNPRYAQQLRQACSSGRDTFVNLDPTTPNKFDKNYYTNLQSNTGPLTSDQVLHSTPGEDTVKIVNLFAASQNQFFESFGQSMINMGNIQPLTGNQGEIRSNCRRLN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 2, CUP2.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Protein: PTF1A_RAT
Sequence: MDAVLLEHFPGALDTFPSSYFDEEDFFTDQSSRDPLEDGDELLGDEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDSGSYCCDAGAPLGAFPYSPGSPPSCLAYPCTAVLSPGTRLRGLNGAAAAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGSGTGGCGGPGGSRHLGGDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWADEKQLKEQNIIRTAKVWTPEDPRKLNSKSFDNIENEPPFEFVS
What is the function of this protein?
Transcription factor implicated in the cell fate determination in various organs.  Binds to the E-box consensus sequence 5'-CANNTG-3'.  Plays a role in early and late pancreas development and differentiation.  Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates.  May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase.  Required for the formation of pancreatic acinar and ductal cells.  Plays an important role in cerebellar development.  Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
What are the official names of this protein?
Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex.
Protein: YO09_BPL2
Sequence: MDVKSTEYLQFVKVKWPGKKTYDIEVLNKDGSLTLGYIKWWGPWWTYTFHTISNIVLDPKCLNTITSYINQLMEERKQ
What are the official names of this protein?
Uncharacterized 9.3 kDa protein, ORF9.
Protein: TENA_STAAM
Sequence: MEFSQKLYQAAKPIINDIYEDDFIQKMLSGDIGADALRHYLKADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFEALMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
What is the function of this protein?
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.  Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).  Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant.  Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
What are the official names of this protein?
Aminopyrimidine aminohydrolase, Thiaminase II.
What is the protein family that this protein belongs to?
Belongs to the TenA family.
Protein: IL17_BOVIN
Sequence: MASMRTSSMSLLLLLSLVALVKAGVIIPQSPGCPPTEDKNFPQHVRVNLNIVNRSTNSRRPTDYHKRSTSPWTLHRNEDPERYPSVIWEAKCSHSGCINAEGKVDHHMNSVTIQQEILVLRRESQHCPHSFRLEKMLVAVGCTCVTPIVRHLA
What is the function of this protein?
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.  Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter.  This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.  Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi.  As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites.  In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines.  In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells.  Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance.  Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation.  Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection.  Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis.  As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release.  In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers.  Involved in antiviral host defense through various mechanisms.  Enhances immunity against West Nile virus by promoting T cell cytotoxicity.  May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung.  Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense.
What are the official names of this protein?
Interleukin-17A, IL-17, IL-17A.
What is the protein family that this protein belongs to?
Belongs to the IL-17 family.
What are the subcellular locations of this protein?
Secreted.