Protein: DPCHA_COLHI
Sequence: MSAETPSLLVCGPLISDPDATHLARIRSALVHTPQLAELRQAVTELPGVWSLLAGGEPSLERVHAAPLLQAFAEWINKGNSSGLLAAGQSSRNTRLAVLTVLSHLAEYVTFLRGLDAGAEEDLAGELDEHTKTLGGLRDGGVQGLCVGMLSASALACARNTSEVAELGAVAVRLAMCSAAFVDLDQIQSSDPTVCVSARLPRNAGEGDEQDRQPFQEALESYPEVRIQHSQSSQSWVQKEKAWLTCALRRQAYIGVRMDVAGTTITATKSITGPLTRHLEGQGAMTKEIDLKGRFHYPGHEDALQKLVRLCESTPMLQFPQNRYPLVPLRQTITGDVVTDETPLHETVLRCILTETADWHTTMTRAVSALAGSPETKSSPAGNRTRLLVQLGIAECIPRSVLAGIPSIRVLQPTTGKPARPGHYPDDAIAVIGMSCRFPDAETPEHFWEIIQSGAKAGSVFPDVGSFDCGLFRKSPREAEYMDPQHRLALHLAYEALEAAGHFSPSSSSTDDVGCYVGMSSCDYEDHVNARPPTAFSFTGTARAFASGRISHFFGLTGPSVVVDTACSSSGVAIHTACRAVLSGECAVALAGGVNLMTDEGQAHQNLAGASFLSPTGQCRPFDAAADGYRRGQGGGFVLLKRLSAAVADNDRVLGVIAASAVNNSKGNRSITLPSSESQSRLYRQVLGSANVHPSHVSYVEAHGTGTQKGDPVECQSIRSVFGGSSRAGSSSPIRLGSVKGNLGHGEAASGIASLVKVLLMLQHGVITPQANFSMLNPAIPPLEGDNMEIVVSPASWRGPFRTALVNNYGASGANAAMVVCQAPSTHLSQIASTRTAAMTTTHRYPFVITANTASSLHRSCLALLRFIETLPAGLNNDSLPSLAFHLAQRQNHALVHRIVFSARSVAELKAHLLAQVEGGNIPSDTSSQAQKTGTKPVVLLFSGQTGRRAHLNRDAYTSFHLLRHHLDRCDRTLQTLGLRSLFPRIFDADPLEDLVDLHCMQFALQYSVAASWTDSGLEIKALVGHSLGQLTALCVSGALSLADSLRMVSGRALLIQTAWKQERGCMLSVDADAATVETLAQSVSAEDKVEIACYNAALHQVVAGTEAAVAAFENAAGSSGISTKRLAVTHAFHSKLLDDILPEYHRLLRSLEFRPAKIPIEPCSEFGGGWDSVTPDIVGRQSREPVYFAAAMARVEQRLGSCVWLEVGSGSAAITMARRALESQKPSSQAMVSHSFYAAQLHSPEPVSSVADSTVGLWNEGVRVQFWLYHASQRQSFVPMDLPSYQFDKTQYWLPFIERNKGSDSNDQSASSQAAPDLVTLVGSLGSAEPQAYEFSINQESDEYALFVKGRTVFGHFLAPGSVYAESAARAFALLPTDNTPQPPASVELGQMKLHAPFGLDLQRRLRLVLRQQTASSWEFVVESCPLHDDKEISPKPQASGTVRLQGQGRSPFGTSQSILRRLFDRCGELREDRGASVVQGAYVKKIMSRVASYDDRYFGIRFVASRGLEAVGDVDALPIVSECRAGTALSPPVFDNFLLVAEMHAGSLGDLADDHLYICGGFEAIVPGDQTSQTDGPWTVLSTLERENDKTLVSDILVFHAGSKKLALSILGARLTQIPARSLQKTLDDMNAARPAKVSNSEDVLTPPLPAVESPPTDLSNGQIHCDLRSALSPLIRSTTSLSQLTSSDDTKDSLGLSSRPSITPASSATSENDQDTTALYNLLAEHLDCSNGIPPDMPLGNIGLDSLISIQLQSDLEKLFGKSPALKLIDENTTFLELCGMVLQQDLSSQLKSRLSPVDSANARTTLNEPLQAYGGYGHAMSVVAPAPVSPQDTPPFLPLAVEAFKRVKKDTGAFAQKTGFAGFYPDVQQKQTSLVLSYILEAFATLGCDLGTLQLKDRLPGIPHPAKYQRLMGRLHDILEEAGIISPPDAQLFRYRTDAPLPPPTPSEDLYRQILDECPLYRPDHQLLGVTASRLADCISGRADPLQLLFQDQASLKLLEDVYVSSPMFSTGNSMLGEMLRGLFSQARFQREGGSEKLRILEIGAGTGATTRRVLDQLIQSGVDFSYTFTDISLALVNGSKRKFTASYGRQRVDSDMEFTVLDIERPPPASMLQAFHLVISSNCIHATRDLRTSCGNIEKLVRRGDGMLCLLELTRPLAWLDCVFGLLDGWWRFEDGRKYALAHEDEWRARLESAGFQNVDWTGDGSRESEHFRLITAWH
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable).  The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).
What are the official names of this protein?
Non-reducing polyketide synthase dpchA, Diterpenoid pyrone biosynthesis cluster protein A.