PharMolix/UniProtQA huggingface dataset:
Protein: SUCC_HAEIG
Sequence: MNLHEYQAKQLFEHYGLPVKNGAVCQSVDEVDLVLAQLSGDKWAAKCQVHAGGRGKAGGVKLVQDVEEARSFAEKWLGQRLVTFQTDKLGQPVNQIYFEETCDIDKEFYLSAVVDRASQKVVFIASPAGGMDIEEVAQNTPHLLHKVEIDPLFGGLPYQGRELAFKLGLSDAQNKQFTDIFMGLSRLFLEKDLSLVEVNPLVLTQQGNLVCLDAKIAVDDNALFRHKDLSALQDLTQNDAREAEAEKFQLNYVALEGDIGCMVNGAGLAMGTMDIVKLYGGKPANFLDVGGGATKERVAEAFKIILTDPSVKVILVNIFGGIVRCDLIAEGVIAAVNEVGVRVPVVVRLEGTNAEIGRQILAESDVNILTAQSLQQATELAVNAAKENSNGDFN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SERC_BACFN
Sequence: MKKHNFSAGPSILPREVIEETAKAILDFNGSGLSVLEVSHRGKDFQAVMDEAVALFKEILNIPEGYSVLFLGGGASMQFCMVPYNFLEKKAAYLNTGVWAKKAMKEAKGFGEVVEVASSADANYTFIPKDFTIPADADYFHVTTNNTIYGTELKGDLDSPVPMVADMSSDIFSRPVDVSKYICIYGGAQKNLAPSGVTFVIVKDDAVGKVSRYIPSMLNYKTHIDGGSMFNTPPVLPIYSAMQTLRWIKAQGGVKEMDRRATEKADMLYAEIDRNKMFVGTAAKEDRSRMNICFVMAPEYKDLEADFLKFATDKGMSGIKGHRSVGGFRASCYNAMPKESVQALIDCMQEFEKLH
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDIS_PSEPU
Sequence: MNLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVREPQ
What are the official names of this protein?
Steroid Delta-isomerase, Delta(5)-3-ketosteroid isomerase.
Protein: MTNA_YEAS1
Sequence: MSLEAIVFDRSEPENVSVKVLDQLLLPYTTKYVPIHTIDDGYSVIKSMQVRGAPAIAIVGSLSVLTEVQLIKHNPTSDVATLYSLVNWESTKTVLNKRLDFLLSSRPTAVNLSNSLVEIKNILKSSSDLKAFDGSLYNYVCELIDEDLANNMKMGDNGAKYLIDVLQKDGFKDEFAVLTICNTGSLATSGYGTALGVIRSLWKDSLAKTDKADSGLDNEKCPRMGHVFPLETRPYNQGSRLTAYELVYDKIPSTLITDSSIAYRIRTSPIPIKAAFVGADRIVRNGDTANKIGTLQLAVICKQFGIKFFVVAPKTTIDNVTETGDDIIVEERNPEEFKVVTGTVINPENGSLILNESGEPITGKVGIAPLEINVWNPAFDITPHELIDGIITEEGVFTKNSSGEFQLESLF
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZN143_DANRE
Sequence: MLLAQVNRDTQGMEFQSVDGDPQQVTLCLTEAVTVADDNIDGMDTVSLQAVTLVDGSTAYIQHSPKVSLTENKIMEGQVIQLEDGSAAYVQHLPMSKTGGEGLRLEDGQAVQLEDGTTAYIHAPKETYDQGGLQAVQLEDGTTAYIQHMPQSNTILAIQADGTVADLQTEGTIDAETISVLEQYSTKMEATECGTGLIGRGDSDGVHMQIVLQGQDCRSPRIQHVGEKAFRCEHEGCGKLYTTAHHLKVHERSHTGDKPYICDHLGCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTPCKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEGYFEPPAEAIDDPGLMYTPSVVDDDSGSEQVSGSEIMGQHHVALISQDGTQQVLSQADMQAMGGTITMVTQEGTTITIPAHEAMLSSGGAHSVTMVSADGTEGQVAIVTPDLAAYQTEEGELIQDQEQHEVSTSPHPVTLLATSNGTHIAVQLSDHPSLEEAIRIASRIQQGETPGMDD
What is the function of this protein?
Transcriptional activator.  Activates the gene for selenocysteine tRNA (tRNAsec).  Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter (By similarity).
What are the official names of this protein?
Zinc finger protein 143, Selenocysteine tRNA gene transcription-activating factor.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLNE_BRUSU
Sequence: MTVENAKALFFERNLCALTPLDPERASAFLADLEARAREEELAGVVALLGRKKAADFLSAILDLSPFIREALTRQPRILDRIVSATPESALEAILDEISASGTVAGVSESELMTSLRQLKREAHVLIALCDLARIFNTETTTDRLTDLAEACTGAAVRFLLLDADAAGRINLPDRSNPEKDCGWIVLGMGKFGARELNYSSDIDLIVFIDETKPAIGDPYECVDTFSRLTRRLVRILQDRTGDGYVFRVDLRLRPDPGSTPLAIPVGAALHYYEGRGQNWERAAMIKARPVAGDRLSGKQILAELSPYVWRKYLDYAAIADVHSIKRQIHAHKGHGDIAVRGHNVKLGRGGIREIEFFVQTQQLIAGGRFPELRGNQTVPMLARLAERGWITQQARDALAQEYWFLRDVEHRIQMIVDEQTHILPEDDEGFARVSHMMGYADPAEFSEIFLAALKVVEKQYAALFAQAPELGAASGNLVFTGDVDDPGTLETLSAMGYERSSDICRVIRTWHFGRYRATQSAEARERLTELTPALLKAFAETRRADESLRRFDGFLQGLPAGIQLFSLLQSNPRLLNLLVMIMSAAPRLADIITRNPHVFDGLLDPAIFSEVPTRAYLEERLRAFLGSATDFEEVLDRLRIFAAEHRFLIGIRLLTGAINGVRAGQAFSDLAELMVGRALEAVEAELQRRHGKVKGAKVALLAMGKLGSRELTAGSDVDLILLYDHDKDAEESDGEKPLAPSQYYIRLTQRLIAALSAPTAEGVLYEVDMRLRPSGNKGPVATHIEAFGKYQRNDAWTWEHMALTRARPIHGDEAFIARIKVDIEDVLAMPRDVRKLAGDVREMRELIAQEKPPRDDWDLKLKPGGIIDLEFIAQFATLAGYVKKTPRPFATEEVLANLDPFFADPAMVDGLVEAHRFYTNLSQAIRLCLNDSAGLDQFPPGMRELLCRVAGLPDIERIEYELLEHYRLVRAAFDKLVGHGAD
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: Y442_CHLPN
Sequence: MGFKNICKQGSQLYLNGIFPERILARKLKNCAKSYPRTALTIEVLVSSVLGALKVILIPCASTYAALTLPLRALFNAIKTKSCQHLASYAMAWLLNILTIAVIIGLVFSLVFIPPPVVFISLGLLMSVTTSVTLFQVHKNLFPPYEPPPSRPHTPPPFADEYVPLISESYFD
What are the official names of this protein?
Uncharacterized protein CPn_0442/CP_0311/CPj0442/CpB0458.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0442/CT_006/TC_0274 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEUC_PECCP
Sequence: MGKTLYQKLFEAHVVHEAPNETPLLYIDRHLVHEVTSPQAFDGLRAMGRKVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCAEFGVQLYDLNHPYQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGDAPHGITAKDIVLAIIGKTGSAGGTGHVVEFCGKAIRALSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYLKGRQFAPKDANWDAAVAYWNTLKSDDDAQFDTVVTLDAAQIAPQVTWGTNPGQVIAVNQEIPNPDSFSDPVERASAAKALAYMDLQPGIKLTDVKIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAAGVQAIVVPGSGPVKTMAELEGLDKVFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRAGRTHLVSPAMAAAAAVTGRFADVRELN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ACP_BRAHO
Sequence: MALIDEIKDVVANQLNISDKSKITDTASFVDDLNADSLDLVELIMELEKRYEIKIPQEDQEKIKNVADAAKYIEEHKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).  Has hemolytic activity forming pores approximately 1 nm in diameter into erythrocytes.  Is able to induce murine colonic lesions and to disrupt the integrity of epithelial cell monolayers.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_RENSM
Sequence: MSVETSSETGNKPDIKPRSRIVTDGIAAAPARGMLRAVGFGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVHAGGGFPMIFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERIDGSVLLAGCDKSLPGMLMAAARLNVSSVFLYAGSIMPGWVKLEDGTEKDVTLIDAFEAVGACAAGKMSVGDLDRIERAICPGEGACGGMYTANTMACIGEALGMSLPGSAAPPSADRRRDMFAHRSGEAVVELLRRGIRSRDIMTKEAFENAIAVTMAFGGSTNAVLHLLAIAREAEVDLQLEDFNRIGDKIPHLGDLKPFGRYVMNDVDRVGGVPVIMRALLDAGLLHGDALTVTGKTLAENLEAINPPDLDGKILRALDNPIHKTGGLSVLKGSLAPGGAVVKTAGFDAEVFEGPARVFEREQGALEALKAGEIKAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCIGHVAPEAVDAGPIAFVQDGDLIRVDIPNKSFDLLVDEAELEARKIGWEPLPARFTKGVLAKYAKLVHSASEGAYCG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RPOB_BDEBA
Sequence: MSDFLITESTLEKTPVTASNIRVRKSFAKNKQVIDIPNLIELQKSSYEAFIQKDMDPDRRGDAGLNGVFKSVFPITDFNNTASLEFVSYTLEPAKYDVDECRQRGMTFAAPIKVTLRLIVFDVDEETEARSIRDVKEQEVYLGEIPLMTANGSFIINGTERVVVSQLHRSPGVFFDHDGGKNNASGKLIYSARVIPYRGSWLDAEFDQKDLIHVRIDRRRKFPVTILLKALGYNSEQLLEYFYDLDEVYVKGGKLFRKLDIERMSGQRALTDIVDPKTGEALVKAGRRITRAIVKKIKDLDITELDVLPEDLEGKVLAKPLIDESTGEIIADANAELNAAIIKRSIEAGIESFFMIFFDGLTVGPYLRNTLLVDKVSNKEESLVEIYKRLRPGEPPTLEAATTFFGRLFFDPETYDLSEVGRIKINHRFGISMDECPPSHRTLTHKDILSTIKTLIDLKNGRGVIDDIDHLGNRRVRSVGELLENQYRIGLVRMERAIRERMSLQDVETMMPHDLVNAKPVNAVVKEFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRDRAGFEVRDVHPTHYGRICPIETPEGPNIGLIASLATYARINNYGFIETPYRKVEAGQVSKDINYLSALEEAGHHIAPAARDEAGNKAIQTATTITRRDGEYEIVDKDKVALMDVSPSQLVSIAASLIPFLEHDDANRALMGSNMQRQAVPLLRSRAPLVGTGVERLVARDSGTSIVAQNDGIVEEVDASRIVIRRFAKGGELGANVDIYNLTKYQRTNQNTCFNQKPIVTVGDKISKGDIIADGPSTELGELALGQNILVAFTPWQGYNFEDSILISERLLKDDVYTSIHIEEFECVARDTKLGKEEITRDIANVGEEALKDLDSSGIIRIGAEVRPGFILVGKVTPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRAPSGVYGTVIDAQVYSREGADRDERLSLIIEEKKRKLEKDLAVEQNVIKNNAISKLRDILVGKITTGVLLNEDGSQKLLNKGQEITEADLETVPFELLNYIPLEQDLEFQVNKIIDNARNQLDAVKLVFNEKIDRLRKGDELPPGVIKMVKVYVAIKRKMQVGDKFAGRHGNKGVVSKVLPAEDMPYLADGTPVDMVLNPLGVPSRMNIGQILEVHLGWAAHNLGKQLGAHLEKWNAENARTEMKDIFSDSDISAKLDKADDASLKSMVQRMKHGIHVGTPVFDGARESDVKGLLAKAQVPSSGKSVLFDGRTGEPFTNPVTVGIMYMLKLHHLVEEKIHARSIGPYSLVSQQPLGGKAQFGGQRLGEMEVWAIEAYGAAYSLQEFLTVKSDDVAGRTRMYESIVKGENILEPGLPESFNVLVKELQSLALNVELMESDILRDQDEDFGDEEVIEVEPVAPVASKDEPEQH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: FOLB_METEA
Sequence: MADRILVHRLAVFARHGVLPEEERLGQRFYISLECRLDLAPAGRSDDVAATVSYADLAEIALDIATNRRFALIEALAEAIAETCLARFPRIETIAVRIDKPSAPIPAVLDYAAIEIVRGRSDSVATTETR
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: RECR_RHIL3
Sequence: MAKRVTGPEIEKLIQLLAKVPGLGPRSARRAALHLIKKKDQLLGPLSHAMGEAYDKVKICSRCGNVDTVDPCIVCTDVQRDQSVIIVVEDVSDLWALERAGAMNAAYHVLGGTLSPLDGVGPDDLNIRGLIDRVGEGGIRELIIAVNATVEGQTTAHYITDQLQGLDVKITRLAHGVPVGGELDYLDEGTLAAALRARTVI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: CALB_PSEAE
Sequence: MVADIAYLQQSQQEINQLEALFARQRAAYLAQPMPDATQRVQWLKALRDLLFKEQQALIEAIDRDFSARSADETLLAEIMPSLHGIHYAAKRVKKWMKPARRAVGLQFQPASAQVVYQPLGVVGVIVPWNYPLFLSIGPLTGALAAGNRVMIKMSESTPATGRLLKDLLARIFPEDQVAVVLGEVDVGVAFSKLPFDHLLFTGATSVGKHVMRAAAENLTPVTLELGGKSPAIVSDSVPMKDAAERIAFGKSLNAGQTCVAPDYVLVPSRRVEEFVSQYKEVVQGFFPRLSDNPDYTAIINERQLGRLRGYLDDAREKGATLVPLFAEGQQRRLPQTLLLNVSDDMKVMQEEIFGPLLPVIPYERLEDALAYVNQRPRPLALYYFGYDKAQQQRVLHETHSGGVCLNDTLLHVAQDDIPFGGVGPSGMGHYHGHEGFLTFSKAKGVFSKPRFNAARMIYPPYGKSIQKLVYKLFVR
What are the official names of this protein?
Probable coniferyl aldehyde dehydrogenase, CALDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: KINE_BACSU
Sequence: METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAIFICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLWKEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNRKGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFREIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKRKYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESELKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENLASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIESIITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEPNQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEPFYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE
What is the function of this protein?
Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions.  Also able to weakly phosphorylate spo0F.
What are the official names of this protein?
Sporulation kinase E, Sensor histidine kinase E.
Protein: KGUA_ALCBS
Sequence: MADKGTLYIISAPSGAGKTSLVAALVDKLAQVRISISHTTRAMRPGEKDGVNYHFTDRDCFVRQVEQGRFLEHAQVFGNLYGTSADWVAQTLRTGDDVILEIDWQGATQIRKQLPDSVSIFILPPSLEALAGRLRGRETDDETVIQQRLDGAQEEMSHYGEFDYLVVNDDFQRALYELEAIVEARRLVTARQVARQAATLQNLLARR
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_TETTS
Sequence: MGIHKLMDLLKEKAPGCIKTSDLKFYAGRMIACDASMAMYQFLATTSSASDFQIQNLTDKDGNKTGHLVGLLNRTVMLIENGLKPVWVFDGKPPQFKSGELARRQKAKDEAAEKQKTAIETGDMQEALKQEQRNLHITKEMKADAIKLLQLVGVPVILAPCEAEAQCAALAKAKKVFATVTEDMDALTFATPFLLRNLNSKKEPITEINYEKMLQELKLSHNEFVDLCILCGCDYLGRIEGVGPVNAFKLITEHKSLEKVLEHMEEVNKQSTKKQKYTVPSSYDYVSARDLFINPEVTDPETIQLEWKKPDVEELKKFLVEEKGFSEQRVTSQMEKVLNAKEHKGSQTRLNDFFKVQPKDTSSTSKASKKPTNTKSANKKGGKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: AQP3_HUMAN
Sequence: MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
What is the function of this protein?
Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639).  Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content.  Involved in skin hydration, wound healing, and tumorigenesis.  Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.  Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells.  It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
What are the official names of this protein?
Aquaporin-3, AQP-3, Aquaglyceroporin-3.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: CYAY_ECOHS
Sequence: MNDSEFHRLADQLWLTIEERLDYWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFWDLLEQAATQQAGETVSFR
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: RUVB_BIFLS
Sequence: MNETTDYGASNTGANEESLRMVSSQPIGNEPASDEELRPHVLGGFIGQPRLKAQLQLFLDAARKRDVPPDHILLAGPPGLGKTTLAMIVANELEVPIRVTSGPAVQHAGDLASILSSLDTGEVLFIDEIHRLPRAAEELLYIAMEDFRVDVMVGKGPGASSIPLTLPRFTVIGATTREGMLPSPLRARFGFTAHLDFYPHDELQKLIERSANVLGVNLGDGSARELALRSRGTPRIANRLLRRVRDWAIVHDLIEVRSDDVKEALALYQIDSEGLDRLDIAVLDAIVRNFNGGPVGLNNLAAMVGEESETVETVCEPYLVREGFLIRTPKGRVATEKAWRHLGITPRDDVSKPF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: METAA_PARDP
Sequence: MPITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGATPLQIDFQLIRMSDHESRNTAADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEVTYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKHMLDHKAFGCFRHRNLVPASPYLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEYDSTTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHFDLNRIGEA
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TERL_BPP1
Sequence: MARSCVTDPRWRELVALYRYDWIAAADVLFGKTPTWQQDEIIESTQQDGSWTSVTSGHGTGKSDMTSIIAILFIMFFPGARVILVANKRQQVLDGIFKYIKSNWATAVSRFPWLSKYFILTETSFFEVTGKGVWTILIKSCRPGNEEALAGEHADHLLYIIDEASGVSDKAFSVITGALTGKDNRILLLSQPTRPSGYFYDSHHRLAIRPGNPDGLFTAIILNSEESPLVDAKFIRAKLAEYGGRDNPMYMIKVRGEFPKSQDGFLLGRDEVERATRRKVKIAKGWGWVACVDVAGGTGRDKSVINIMMVSGQRNKRRVINYRMLEYTDVTETQLAAKIFAECNPERFPNITIAIDGDGLGKSTADLMYERYGITVQRIRWGKKMHSREDKSLYFDMRAFANIQAAEAVKSGRMRLDKGAATIEEASKIPVGINSAGQWKVMSKEDMKKKLNLHSPDHWDTYCFAMLANYVPQDEVLSVEDEAQVDEALAWLNE
What is the function of this protein?
Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging.  Heterooligomerize with small terminase protein to be docked on capsid portal protein.  Forms a ring-like structure through which genomic DNA is translocated into the capsid.  May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.
What are the official names of this protein?
Probable terminase, large subunit, DNA-packaging protein B, PACase B protein, Terminase B protein, Terminase large subunit.
What is the protein family that this protein belongs to?
Belongs to the punalikevirus large terminase family.
Protein: HSP16_ONYPE
Sequence: MLFSLINQNQDLLENLFEDFKTNSLTNNNNIMKTDIQEQDNQYFITIELPGFKKEDVKVALEEGYLVVEAKNSKKNQIKEANFIRKERFQGFLRRSFYLGDDFLLEDIKGSLEQGLLKLSVPKKEVKPKEKHYIKLN
What is the function of this protein?
Probable chaperone.
What are the official names of this protein?
Probable Hsp20 family chaperone.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: ATPE_CARHZ
Sequence: MADKIKLEVVTPERVVANEHVDFVVAPGVEGEIGILPFHAPLITSLDIGILRYTVEGKTEKIALSGGFLEVKGNKVVVLANAAERGEEIDVERAQRALERARERLARRTPDIDVLRAELAMRRALNRLKAAGKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.