PharMolix/UniProtQA huggingface dataset:
Protein: PRGC2_MOUSE
Sequence: MAGNDCGALLDEELSSFFLNYLSDTQGGDSGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSELFQIDSENEALLAALTKTLDDIPEDDVGLAAFPELDEGDTPSCTPASPAPLSAPPSPTLERLLSPASDVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPTLRAQSRPCTELHKHLTSVLPCPRVKACSPTPHPSPRLLSKEEEEEVGEDCPSPWPTPASPQDSLAQDTASPDSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPIPQACSSLSRQVQPRSRHPPKAFWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPTRQKREEDEEEEEEEEEEEEEKEEEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLDTETHNLEEDLGSLTDSSQGRQLPQGSQIPALESPCESGCGDTDEDPSCPQPTSRDSSRCLMLALSQSDSLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKPDTKLSPGQDTAPSLPSPEALPLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVLRPEAALQRKVLRSWEPIGVHLEDLAQQGAPLPTETKAPRREANQNCDPTHKDSMQLRDHEIRASLTKHFGLLETALEGEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRRESRGPCSDGTPSVRHARKRREKAIGEGRVVYIRNLSSDMSSRELKKRFEVFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH
What is the function of this protein?
Plays a role of stimulator of transcription factors and nuclear receptors activities.  Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.  May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed.  May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting.  Stimulates SREBP-mediated lipogenic gene expression in the liver.  Induces energy expenditure and antagonizes obesity when overexpressed.  Induces also the expression of mitochondrial genes involved in oxidative metabolism.  Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
What are the official names of this protein?
Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, ERR ligand 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KLH40_XENLA
Sequence: MALPTQQSEELRLYQQTLLQDGLKDMLDHNNFIDCVLKIQGKEFPCHRLVLASCSPYFRAMFLSDLEESKKKEIDLEDVDPDVMGKILHYIYTSEIEITEKNVQDIFSVANMFQIPSIFTVCVSFLQKKLCLSNCLAIFRLGLLLDCPRLAVSARDFVCDRFNLIARDSELYELSPDELIAVISSDSLNIEKEEDVFEVVMKWASKEKEKRTKALPVIFESIRFCLIPQDYIKNKVEKHELVKPNKELLKKLQIVKDAQQGKLPSLKKKTSAKASEGKDGEQVVNGELDEEEEALPGILNDTLRFGMFLKDMIFMISDTGAVAYDPSANECFFASLSAQIPKNHVSLATKENQLFVAGGLYYNEESKEEPLSSYFLQFDHLDSDWLGMPPVPSARCLFGLGESENSIYLIGGKELKEGEQMLDSVLCYDRPSFKWGESDPLPYKVYGHTVVSHDNLVYVLGGKGNEKKCLKRVCVYNPKKFEWKDLAPMKTGRSLFGATVHKGKIFIAAGVTDTGLTNTIEAYDIKTNKWEDFTEFPQERSSLSLVSMNGTLYAIGGFATIENESEELVPTELNDIWRFNEEEKKWEGILREIRYASGATFIAARLNILRLTKM
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development.
What are the official names of this protein?
Kelch-like protein 40, Kelch repeat and BTB domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the KLHL40 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, myofibril, sarcomere, I band.
Protein: DIAA_YERPN
Sequence: MLERIKGCFTESIQTQIAAAEALPDAISCAAMALVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNADNVVLTAITNDRLHDEVYAKQVRALGQAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGQLDVEIRIPSHRGARVQELHMLTVNCLCDLIDNTLFPHQND
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: CBPM_ECOUT
Sequence: MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPSEIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: CAID_SALCH
Sequence: MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGIVNRVVSQSELMDSARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHSEDALEGPQAFAEKRDPVWKGR
What is the function of this protein?
Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
What are the official names of this protein?
Carnitinyl-CoA dehydratase, Crotonobetainyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: GCYB1_HUMAN
Sequence: MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
What is the function of this protein?
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
What are the official names of this protein?
Guanylate cyclase soluble subunit beta-1, GCS-beta-1, Guanylate cyclase soluble subunit beta-3, GCS-beta-3, Soluble guanylate cyclase small subunit.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIFE_ECOL6
Sequence: MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD
What are the official names of this protein?
UPF0438 protein YifE.
What is the protein family that this protein belongs to?
Belongs to the UPF0438 family.
Protein: P5CR1_HUMAN
Sequence: MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
What is the function of this protein?
Housekeeping enzyme that catalyzes the last step in proline biosynthesis.  Can utilize both NAD and NADP, but has higher affinity for NAD.  Involved in the cellular response to oxidative stress.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 1, mitochondrial, P5C reductase 1, P5CR 1.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y2163_TRIL1
Sequence: MRIVVITGMSGSGKSTAVRALEDEGFYCIDNLPVRLFRQFVELIEKSGESFKGVVLVTDIRGRDLSTGIVESFRELRSVGHELEVLFFDASDEVLIRRFAETRRRHPADEHCTVPEGIRIERERLAALRQNATLIIDTSEFNVHQLKEQVIRAIKGEQGSSNFTVEVVSFGFRYGVPLDASLVMDVRFLPNPHFVPALRPYSGQEPAVRQFVLEQPDTTAFLDHFFNLLQFLIPAYCREGKSYLTIAIGCTGGRHRSVAITEATAARLETLGLKVRISHRDIEKG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Glov_2163.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: 084L_IIV6
Sequence: MAKVIKINLIVNKRMSPAIILIGVLILIVLFVIKFNSSEVSSILTSEVTSEGDDEHETETRETTGCISQLNTLRATLAAKKKELKTLRTARKKECTEQLAKTQAEVDRIQAKIDNFSSRTKIVPLPGGEVGPPYNPPPPRTNTRPNPRPNPRPAQLPQLYNYGYY
What are the official names of this protein?
Uncharacterized protein 084L.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BZP19_ARATH
Sequence: MEDGELDFSNQEVFSSSEMGELPPSNCSMDSFFDGLLMDTNAACTHTHTCNPTGPENTHTHTCFHVHTKILPDESDEKVSTDDTAESCGKKGEKRPLGNREAVRKYREKKKAKAASLEDEVARLRAVNQQLVKRLQNQATLEAEVSRLKCLLVDLRGRIDGEIGSFPYQKPMAANIPSFSHMMNPCNVQCDDEVYCPQNVFGVNSQEGASINDQGLSGCDFDQLQCMANQNLNGNGNGSFSNVNTSVSNKRKGGHRASRAV
What is the function of this protein?
Transcription factor involved in the response to zinc ion deficiency.  Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also called zinc deficiency response element (ZDRE).  The ZDRE sequence is conserved in the plant kingdom and present in the promoters of genes that constitute the primary response to zinc deficiency, comprising additional ZIP metal transporter genes (PubMed:20479230, PubMed:26306426).  Required for zinc accumulation in roots.  Mediates the expression of the zinc transporters ZIP3, ZIP4, ZIP5 and ZIP9 during growth in zinc-deficient conditions.  ZIP9 transporter is involved in zinc uptake in roots (PubMed:26306426).
What are the official names of this protein?
Basic leucine zipper 19, AtbZIP19, bZIP protein 19.
What are the subcellular locations of this protein?
Nucleus.
Protein: UDG_ECOLI
Sequence: MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIKQNIPMLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD
What are the official names of this protein?
UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Protein: KITH_ICHVA
Sequence: MALREGPTPARFLPEGLVFCVEGNIGCGKSTLVKALMERVAGSGVNVVEEPVDQWVNHNGKNYLELSYTDPTGYAVPFQNLVFDSYVNVQRLQNPDIMERSPMSATRVFCAVNGSRGVIPATALPGMAARGEAVMRTIATRPVFVYLELPPEECLRRMRRRDRTGEAGVGLDYLRLLHERYEAWLSSAEDVERVDASRSREEIVDRVIEILCRRHPRLRAPLTRKSQL
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the DCK/DGK family.
Protein: RLMH_SYNWW
Sequence: MKYRIISVGRIRESFYLEGVREYLKRLGPYTSIELIDGLEEKIGPRAGEKEIQAILQKEAEKIRRWLDKDEILVVLDLEGQVRSSEEMARQLEKWNASGKSRVTFLLGAAHGLANEIKQQAQETISLSRLTFPHQMAVLILAEQIYRGFKILKGEPYHR
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG1_BRUO2
Sequence: MTQKNGPLRVGIGGPVGSGKTTLTEKLCKAMRDKYSVAIITNDIYTQEDALILARRQALSEDRIIGVETGGCPHTAIREDASINLQAVVEMTRRFPDLDVVFIESGGDNLAATFSPDLADLTLYVISVCQGEEIPRKGGPGITRSDFLVINKSDLAPYVHVDLEVMEADAMRMRAKRPFGFTDLHRGKGVQEIIDFIVENGGLEPRSN
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUBA_BACSU
Sequence: METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIFTPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIVSIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQAATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQTYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYLGPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFLLLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV
What are the official names of this protein?
Putative transport protein YubA.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_CHLCH
Sequence: MTIPEDLRYTKDHEWMKLLDDGTALVGITDFAQSELGDIVFVELKADGTTLKTHESFGTVEAVKTVADLFAPVAGEIVASNPELASAEVVNQDPYNAWLIKMKVANPAEVEALLDAAAYRQLIGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: HPR_GEOSW
Sequence: MKTTEQNYSIKEAMLFSQRIAQLSKALWKSIEKDWQQWIKPFDLNINEHHILWIAYHFKGASISEIAKFGVMHVSTAFNFSKKLEERGLLSFSKKQDDKRNTYIELTEKGEEVLLKLMESYDPTQNAVFNGALPLRELYGKFPEILEMMCIIRNIYGDDFMEIFERAFENIKNDFVEQDGKLVKRNAKSQEKEKELTSQSS
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: MRS2D_ORYSI
Sequence: MAARRRHVAAGAGAPAPAAGEWPAVTAGGGAAWALSPVEEVGTKQELMRRTGLPPRDLRALDPALSSAASASSCRPSAITGRDRAVVVNLDRARAVITASEVLVPSPRDPAVAPLVRELRARLALAASPTPAPSPSPPQHGMAVGMDGSISPSQASRGGEEAAGNGKDGEALGGGDKALPFEFRALEVCLEFACKSLEHETCTLEKEAYPALDELTSKVSTLNLERVRQIKSRLVAISGKVQKVRDELEHLLDDDMDMAALHLTEKLAYQSSRFDIDKEASELEDHSSRDEEGVEGGGGGDGDDETIAGGGSFSPNTDELEILLESYFVQIDGTLNSLSTLREYVEDTEDYINMMLDEKQNQLLQMGILLSTGTLVSSCAIAVTGVFGINVHISLYDSPASSAAFPCAAAGIVAGSLALYLAALLCYKRAGILQ
What is the function of this protein?
Putative magnesium transporter.
What are the official names of this protein?
Putative magnesium transporter MRS2-D.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL34_BURCJ
Sequence: MKRTYQPSVTRRKRTHGFRVRMKTAGGRKVINARRAKGRKRLAI
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: FLIT_ECOL5
Sequence: MNNAPHLYFAWQQLVEKSQLMLRLATEEQWDELIASEMAYVNAVQEIAHLTEEVAPSTTMQEQLRPMLLLILDNESKVKQLLQIRMDELAKLVGQSSVQKSVLSAYGDQGGFVLAPQDNLF
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: Y719_STAAB
Sequence: MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSEIDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein SAB0719.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: H2A_DROSI
Sequence: MSGRGKGGKVKGKAKSRSNRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RAB13_CANLF
Sequence: MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDSFNNTYISTIGIDFKIRTVDVEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQAIKLAREHGIRFFETSAKSSTNVDEAFSSLARDILLKSGGRRSGNSHKAPGTDLKPCDKKNTSKCSLG
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin.  Thereby, it regulates the assembly and the activity of tight junctions.  Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively.  Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier.  Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis.  Also involved in neurite outgrowth.  Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome.  Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
What are the official names of this protein?
Ras-related protein Rab-13.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells.
Protein: QUTD_ASPFU
Sequence: MSILALVEDRPTPKEVYNWKIYLLAAVASFTSCMIGYDSAFIGTTLALSSFREEFGFSTMSKTAVNLVSANIVSCYQAGAFFGAFFAYPIGHFWGRKWGLLFAGTIFTLGAGLMLGANGDRGLGLLYGGRVLAGLGVGAGSNITPIYISEMAPPSIRGRLVGVYELGWQIGGLVGFWINYGVSETLAPSHKQWIIPFAVQLIPSGLLLIGAVFLKESPRWLFSRGRREDAIKNLCWIRQLPADHIYMIEEIGAVDQALEEQRTTIGLGFWKPFKAAGTNKKVMYRLFLGSMLFFWQNGSGINAINYYSPTVFKSIGLHGANTSMFSTGIFGVVKTVVTFVWLLYLIDRVGRRLLLLIGAAGAAVCLLIVGAYIKIADPASNPTQEMTGGGIAAMFFFYLYTVFYTPSWNGTPWVMNSEMFEPNMRSLAQACAAASNWLWNFLISRFTPQMFAKMEYGVWFFFASLMLLSIVFVFFLVPETKGIPLESMDVLFESKPIWRAHATVLAKLREDEEQFRHDIEESGYSKTGEQQVEHVSEDLPKV
What is the function of this protein?
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
What are the official names of this protein?
Probable quinate permease, Quinate transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane.
Protein: LTOR5_BOVIN
Sequence: MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathwayn.
What are the official names of this protein?
Ragulator complex protein LAMTOR5, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR5 family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasm, cytosol.
Protein: RADA_SYNY3
Sequence: MAKARTKFVCSACGADHAQWFGRCPKCHEYGSLQEEIVNAVSSGTNHRSLGAQKSRSSKVKTGQPQAALTFSQIRQENQGRFLSGYGELDRVLGGGIVPGALILIGGDPGIGKSTLLLQVAFQLATRLPRILYVSAEESGQQIKLRATRLGITQTVEPSQAQDGINNLAHDGNLFVLPETNLDDILRELEALQPQVAIIDSIQNLYFPALSSAPGSVSQVRECTGLLMQLAKRDHISLFIVGHVTKEGAIAGPKVLEHLVDTVLYFQGDRFASHRLLRSVKNRFGATQEIGIFEMVQSGLQEVLNPSQLFLGSREEFMSGTAITVACEGTRPLVVELQALVSPTSYASPRRSTTGVDYNRLLQVLAVLEKRLGVPLSKLDAYLSVAGGLEVEEPAVDLAMAIALVASFRDRVVDPTMIILGEIGLGGQIRPVSQLEIRLKEAAKLGFKKAIVPKGQTGIESAGIKLIPVGKVFAAIAVALPANENTTDQGNGSEAKIEEDLGKKD
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: RM42_HUMAN
Sequence: MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR
What are the official names of this protein?
39S ribosomal protein L42, mitochondrial, L42mt, MRP-L42, 39S ribosomal protein L31, mitochondrial, L31mt, MRP-L31, Mitochondrial large ribosomal subunit protein mL42.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL42 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FB205_ARATH
Sequence: MEPIPNDLILEIFSRLPAKSVIGFRTLSKHWASILRSPVFTELFLTRSSNRPRLLFAAERNGEWLFFSSPQPQNRYEKSSHLDYHTKFSGDVSRFICSYVSGLLCFPDLWLSKDASPVICNPTTGMYESLPDLMRYKNARGFLGFDPIGKQFKVLSEAYPFSDQREHHEILTLGTEELSWRSNIISCPAYDRSLSEGICINGVLYYLAQTLGVPSCVIICFDVRSEEFKYFDAGCFNDQLDDTSGLILVNYEGKLSGINWKYGQAGERRTVELRMWVLEDAEKHEWVKYVYTLPENEVLDSCDFSVAGVTTRGDIVLCMKYTCKPFYVFYFNPERNTLQSVEIQDFGANLEAVENCGRVYAFVNHVEDLRVNKGKQLKSSISQVKHLCSCCNKVSQPDYHYQKA
What are the official names of this protein?
F-box protein At3g57590.