PharMolix/UniProtQA huggingface dataset:
Protein: HSSS_STAA2
Sequence: MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR.  HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
What are the official names of this protein?
Heme sensor protein HssS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMPA_PECCP
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKVGQSLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINALNETGSMEAVCFLTELHVKGRNTYWKVRQAVETAKETLYTFDQLKSNKVELRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADTYSQNIITRVIGEQQMKELGMNAYLAVGQGSQNESLMSVIEYKGDPNPETRPIVLVGKGLTFDSGGISIKPADSMDEMKYDMCGAATVYGVMRMAAELALPLNIIGVLAGCENMVDGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDTLTYVERYEPDVVIDVATLTGACVIALGHHITGLMANHNPLAHELLSASEQSGDRAWRLPLTDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYSWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGQNDVE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH3_VANPO
Sequence: MSKQPVISRFFKPIARKEVTSEKGVEKEKPVDLDEEKHNEPATTSRLMPKGFDAAAETVTDEVIEIEVEIEHESEPKIEIKNGTVTAENKSMDFAEKLNRIWNDKKRVISNNDNDDSDGENDTIVKKSKNNSNKLTPLDQQVKDLKLLHMDKILVIRVGYKYKCFAQDAEIVSKILHIMLIPGKLTIDESNPQDSNYRQFAYCSFPDIRLKVHLETLVHNNLKVAVVEQSETSAIKKNSNASSKNSVFERKISGVYTKATFGINSAFSSNRKNVLGQYNSIWIINFSEIDKINSSFFMISVNLNSGEIIYDTFECSTTSIENLETRIKYLNPIEVLTVSALPEKVKLRLHGSNSTILLKEKEDIDKEIMEEINKSTKGLNLSAELFELVPVLYKYLTEYNNEELLLISENYKPFASKKHMVLNAAAIESLGIFGEEGGKGSLFWLLDHTRTSFGSRKLREWILHPLLDKKEIEDRLDAVDCIIHEVSNIFFESLNKMLTNVPDLLRTINRIAYGTTSRKEIYYFLKQMKSFSDHFQLHSNYLNSQVVSNDGRIHKSSALLTNLLTEITSGLKEINIENILSMINVSSVMEKDTYKQVSEFFNLNYYDHAEEIIKIQGNINEVKNELAEELSSIRKILKRPHLNYKDEMDYLIEVRNTQTKGLPSDWIVVNRTKMISRYHTPTSRKLIEKLQYQKDILYQETQKEYFQFVKRIKNDYFALNKIINHIATYDCILALASTSQNMNYVRPVLTDESQFIDAKNARNPIIESLDINYVPNDVNLSHSAGKFLIITGPNMGGKSSYIRQVALLVILAQVGSYVPADFMKTSIFDKILTRIGAYDNLLKGQSTFKVELLEIQNIIKNKTENSLLLLDEVGRGTSTEDGKAISYSIVDYFINLPVCPLVLFTTHYPFLGSINSKILKSYYMDFVEQKKEGEDWPSIVFLYKLRSGITDSSFGLNVARLAQIDKDIINHAFSISEKIRQETETANTMNLPILLKHILSSNDLKPQQKIIEILNLQNDSQEL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD5_BOVIN
Sequence: MNTNEAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQMPDEVGIVIDGFPRDVAQALSFEDQICTPDLVVFLACTNQRLKERLLKRAEQQGRPDDNLKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDSKLFPNKEAAAGSSDLDPSMMLDTGEVIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLKKCKIIFMIGGPGSGKGTQCGKLAEKYGFTHLSTDELLQNELSSESGRSKLIRDIMERGELVPSGIILELLKEAMVASLSNTKGFLIDGYPREVKQGEEFGRRIGDPHLVICMDCSADTMTNRLLQRSRNSPQADDNTTTIAKRLETYYRASIPVVAYYETKTQLHKINAEGTPEEVFLQLCTAIDSIF
What is the function of this protein?
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.  Active on AMP and dAMP with ATP as a donor.  When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP.  Also displays broad nucleoside diphosphate kinase activity.
What are the official names of this protein?
Adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y321_PARDP
Sequence: MTLLPDPAEARAARLACRQGAPRPTAGMAPGFTQCNMISLPKDWAWDFLLYAQRNPKPCPVLDVTDPGSHRTALAPKADLRTDIPLYRIWRDGVLAEETPDATAAWAEHPDLVTFLIGCSFTFETPLQQAGIEVRHIAQGCNVPMFLTDRDCRPAGRLHGKMVVSMRPIPAGRVAEAAMISGRTPAVHGAPVHIGAPEALGIADLSRPDFGDPVQIRPGEVPVFWACGVTPQAALMASKPPFAITHAPGYMFITDVPDTHWQV
What are the official names of this protein?
Putative hydro-lyase Pden_0321.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: Y1440_STACT
Sequence: MVKETIPKEGENIKIQSYKHDGNIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGVYYYCNLSSPFVCDDEALKYIDYDLDVKVYPNGKYHLLDEDEYQQHMQQMNYPKDIDVILRRNVDILQQWIEQKKGPFAPDFIKVWRERYKKLRQKS
What are the official names of this protein?
UPF0374 protein Sca_1440.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: PHZA_PSECL
Sequence: MTGIPSIVPYALPTNRDLPVNLAQWSIDPERAVLLVHDMQRYFLRPLPDALRDEVVSNAARIRQWAADNGVPVAYTAQPGSMSEEQRGLLKDFWGPGMKASPADREVVGALTPKPGDWLLTKWRYSAFFNSDLLERMRANGRDQLILCGVYAHVGVLISTVDAYSNDIQPFLVADAIADFSKEHHWMAIEYAASRCAMVITTDEVVL
What is the function of this protein?
Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control.  This isochorismatase may remove pyruvate from chorismate during the formation of the phenazine ring structure and/or stabilize the phenazine biosynthetic complex.
What are the official names of this protein?
Probable isochorismatase, 2,3 dihydro-2,3 dihydroxybenzoate synthase.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: ACPS_THEYD
Sequence: MIEGVGVDIVAVERIKKIYEKCGEKFLNKVFTEGEISYSFSHANPFPHLAARFAVKEAVIKALKKQKGLTLKNIEVRNNSDGSPEVKIPGFNKKIFISISHEKNYAVAFVVIT
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y468A_MYCGE
Sequence: MVLKTKENKKFDIYLKSSDFAVSKKASKLIKKLNKKHPKRKSLNSFEAKKYDIYFKEVCKAVTNGINNQLICNHINLKILPGEFVVILGKSGSGKTSLLSLISALDRPTSGDSFVCGTNTICCSDAKLTALRNKNVGYIFQQYGLLRDLDVDDNIKLALPLKKRFNNNLEELLERLELKEHRHKKVHKLSGGQQQRVAIARALIKEPKILFGDEPTGAVNIDISKKILQFFVEYNRDKGTTIVIVTHNEKIVELAKRVIKIHDGKIIVDYLNQNPKTIEQINWV
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MG468.1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: TRMD_BIFAA
Sequence: MKIDIVSVFPEYFEVLNLSLLGKAQEKGLVEVTAHNLRDWTHDVHHSVDDTPVGGGAGMVMKPEVWSECLDELLHLEPTTVTCDSMVTCDSTADADDTASADAAEPAESATEIAANADTVPATDRPVLIFPNPSAPLFTQQDATELSHANHLLFGCGRYEGYDARIPQYYRAQGVDVREYSIGDYVLNGGEVAVSVMLEAITRLLPGFMGNAASIVEESYTGENALLEHRQYTKPADWRGIKVPDVLLSGDHAKVDRFRRDEALAKTNELRPDLIEALDCSKLDKADRKTLMALGWEVSGAHPRQR
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_POPTR
Sequence: MPIGVPKVPFRNPGEDSSNWIDVYNRLYRERLLFLGQDIDSEISNQLIGLMVYLSTESEIKDLYLFINSPGGWVIPGIAIYDTMQFVRPDVQTVCMGLAASMGSFILVGGKITKRLAFPHARVMIHQPFAAFYEAQIGEFVLEAEELLKLREILTRVYAQRTGKPLWVVSEDMERDVFMSAAEAQVHGIVDLVAVA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: ABP5_MAIZE
Sequence: MVRRRPATGAAQRPQLAAVGRGLLLASVLAAAASSLPVAESSCPRDNSLVRDISRMQQSNYGREGFSHITVTGALAHGTKEVEVWLQTFGPGQRTPIHRHSCEEVFIVLKGKGTLLLGSSSLKYPGQPQEVPVFQNTTFSIPVNDPHQVW
What is the function of this protein?
This is probably a receptor for the plant hormone auxin.
What are the official names of this protein?
Auxin-binding protein 5, ABP, ERABP5.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PSD_CYTH3
Sequence: MTIHKEGYRSLFYVSAFLFLLNFLIYYFFPEASILQKTVLVISLLIFLVVLQFFRNPSRTIEINDNQIIAPADGKVVVIEEVIETEYFNEKRRQISIFMSPFNVHSNRNAVSGIVKFFKYHPGKFLVAWHPKSSTENERTTTVVQTKNNEQILMRQIAGALARRIVWYIDENSKVTQGEEFGFIKFGSRVDLFIPLDAKVKVSLNQTTVGGKTVIAEFYS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: BCK1_ASPFU
Sequence: MDGQRQQTYIPAPPPPSATQPSQSHMLSLPPPPPRHLPTQPQGVMPPPPPGPPPGPPPGPGYGASKLANSQLQQQNNLGWQHNWARQALSQGFLPPPPPPPMVPTNQAYGRQTSFSVPNADGPITSATYVPGSNTFGAGVGIPGFDAHTRPSYEAYGTMSGSDRIRGPVHHLYESSGGDGSAYKRDGTVPPTPSARTMPSSLALHDNAQESVASSLPGATAQNHQSQTGQTNEPTKSPSHRQNNSNTLLGGMSPSEAAVQWPLDRVLLWLAKNGFSRDWQETFKTLQIEGADFLDIGHGANGRGNFNKMHNEVFPQLAKECEASGTGWDKERELGEGKRMRRLIRQIHDDDSFDVGIPAQKRRESQAPSEGAPDTSPKLSHEPQSAGPHSGTIENSPNLRAPQLAQPHRHSVQMRSVTLPIPTTHDIASSDFSQTDGISSRSDFSRSVLVGLGVDHRRQSPSMSSDNGNLVAPFRSYEDSPKSGSPATQHATLNQGLSSSSTGDLSVKYEHSRGNSSDSTMGRRYYESRKGQETIRPSPQEMCSRQWTGETSSSYPKEHKGIFNFLKKRSKGGDSTHPSPEEPNLESPTSPVNLRQNGPHLPYTKPSFNASDMSLGERPSSASMSDHERLRGKPAQKGKKWSFVTLDGWNYRLVDITDMDSVETLRAAICHNLGIADWASAQIFLTEPGQSDHEEPLNDTMLALCRRTKSDSIGSLKLFVRGTHLQPVPNHVPNFAGLGVPLPDKHTASPTHHLPRKPLDDEALSRIPPQPQTGPASPQLGIRPQQPKTPAAKFPARDAPQHTEGMSPVEGDQQVGISPEPDKADLLARHEEHKREVERKQKAYLSSKGPPQPRNDSYGETGYRRAGVIDFDERRVSPYEDKKADTLVPLRKPPSAPQESYTLTRINSLRKKDGDRPRAQPAVQTHGLGAVLASMGRMTSAIGTPAPSVPTPTSAGGKQTNFGSFGSPTQGNTKSAPQSSPEKESLDNPGNPAEHRHTKSTAPEIPKPTLQSRKSYGPEFDFEETEVSFQRSPRPQDDSDEDSDDGLFAIPLSNNKASTKENDSGSGTSEAQKRTEKPALTVNTESRLRKGLSVSFRSPSATRESFADANGDSGGREGASFLMAASPEDERPTPRRDSFARGDIWASRPPVEGVIDNLDDFFPDIDLDAPYLDGQGVSPPSSPANRAPPENDLHKKENQPSSSYTGEMNANAGDTLGSNEPTLKPQGGDVVARRNINRSGGGLTRGKSIREVAKGANQASRSRSIHTGNQKSGEILRRKSTKMFGAKIMQIKPKPGSRLSQLDPIPQNNTPSGVPQRQPTFRIIRGQLIGKGTYGRVYLGINADNGEVLAVKQVEINPRLAGQDTDRVKEMVAAMDQEIDTMQHLEHPNIVQYLGCERGEFSISIYLEYISGGSIGSCLRKHGKFEESVVKSLTRQTLSGLAYLHDQGILHRDLKADNILLDLDGTCKISDFGISKKTDDIYGNDSSNSMQGSVFWMAPEVIQSQGQGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAIGAIFKLGSLSQAPPIPDDVSMTISPAALAFMYDCFTVPYRDSSERPTAQTLLTRHPFCEEDPNYNFLDTELYAKIRHVL
What is the function of this protein?
Mitogen-activated protein kinase kinase kinase; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator (PubMed:19715768).  The CWI signaling pathway regulates cell wall integrity and pyomelanin formation (PubMed:19715768).  CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development (PubMed:21883519, PubMed:32005734).  Finally, CWI is constitutively required for A. fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection (PubMed:33010083).
What are the official names of this protein?
Mitogen-activated protein kinase kinae kinase bck1, MAPKKK bck1, MEKK bck1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: VG86_BPML5
Sequence: MPAKNFRRIPDQTDDQGFLIPGYSAWDCQRCGGEVCRYYGQSDVDCPNCGACYNASGQRLRDDWRGNPSAYDDEVGDLEGFETQHSDY
What are the official names of this protein?
Gene 86 protein, Gp86.
Protein: ISDA_STAAM
Sequence: MTKHYLNSKYQSEQRSSAMKKITMGTASIILGSLVYIGADSQQVNAATEATNATNNQSTQVSQATSQPINFQVQKDGSSEKSHMDDYMQHPGKVIKQNNKYYFQTVLNNASFWKEYKFYNANNQELATTVVNDNKKADTRTINVAVEPGYKSLTTKVHIVVPQINYNHRYTTHLEFEKAIPTLADAAKPNNVKPVQPKPAQPKTPTEQTKPVQPKVEKVKPTVTTTSKVEDNHSTKVVSTDTTKDQTKTQTAHTVKTAQTAQEQNKVQTPVKDVATAKSESNNQAVSDNKSQQTNKVTKHNETPKQASKAKELPKTGLTSVDNFISTVAFATLALLGSLSLLLFKRKESK
What is the function of this protein?
Cell wall-anchored surface receptor that participates in the extraction of heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (By similarity).  Receives heme from IsdB and transfers it to IsdC (By similarity).  Also plays a role in the inhibition of host immune response.  Protects S. aureus against the bactericidal protease activity of apolactoferrin.  Decreases bacterial cellular hydrophobicity, which renders S. aureus resistant to bactericidal human skin fatty acids as well as to beta-defensins and cathelicidin.  Also binds fibronectin and chains B-beta and gamma of fibrinogen, promoting clumping of S. aureus with fibrinogen.  Involved in adherence of S. aureus to human desquamated nasal epithelial cells and is required for nasal colonization (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein A, Fur-regulated protein A, Staphylococcal transferrin-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the IsdA family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Encodes an LPXTG motif-containing sorting signal that targets to the cell wall, which is catalyzed by sortase A.
Protein: SGBE_ECOLI
Sequence: MLEQLKADVLAANLALPAHHLVTFTWGNVSAVDETRQWMVIKPSGVEYDVMTADDMVVVEIASGKVVEGSKKPSSDTPTHLALYRRYAEIGGIVHTHSRHATIWSQAGLDLPAWGTTHADYFYGAIPCTRQMTAEEINGEYEYQTGEVIIETFEERGRSPAQIPAVLVHSHGPFAWGKNAADAVHNAVVLEECAYMGLFSRQLAPQLPAMQNELLDKHYLRKHGANAYYGQ
What is the function of this protein?
Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).  May be involved in the utilization of 2,3-diketo-L-gulonate.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase SgbE, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: CH10_RIPO1
Sequence: MAAISINVSTVKPLGDRVFVKVSASEEKTAGGILLPDTAKEKPQIGEIVTVGPGKRNDDGSRSEPEVKVGDKVLYSKYAGTDIKLGGEDYVLLSEKDILAVVD
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNB_PARPJ
Sequence: MPTLWDITPAVDTATPVWPGDTPVGIERVWRMEAGSPVNVARLTLSPHTGAHTDAPLHYDAEGVAIGEVPLDAYLGRCRVIHCIGASPVVTPQHLSGSLDDLPPRVLLRTYRNAPTAAWDSAFCAVAPDTIDLLAARGVKLIGIDTPSLDPQESKTMDAHHRIRTHRMAILEGIVLDDVAPGDYELIALPLKLTTLDASPVRAILRALPESQ
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: Y532_XYLFT
Sequence: MEIKSDHSEHGFQFPGTFELSVVGTAGKALETELPRLLALCGVELVQERISWKHSSTGKYVSVRIGFRALDREQYDAAHQVLRDHPEVKWTL
What are the official names of this protein?
UPF0250 protein PD_0532.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: Y865_MYCCT
Sequence: MNNQFKLKNKKIKPVSILIILFVGFLFLISLIGFIFTSFYTIDLKLAIFFEKGFKYEIVRYWSIFYDILGTTELMVFILFNIMVLIESWFLLKSKTKKDNFWKKNKWILKLVYITVYVVFVVIKCITTYFKINADNGFGYGGDAIYLLSSKYRNICLIVSLVIHCIGLFVGFYIIHYKFKNDPIYLVDKYWIQAVKILFIVLISYTILVLLKGMTSRPYYYNIIYGDLLKQVKLNGHNDWVDHYLNQSTFKHGFNIGDNKYANNIPGEWPWYRINGGLFRPDKNLVQFKHWFDWAFPSGHIGATLIVGCTFFYFLTNNQKLTPLKITLLALYFLHLVSMSFAIVVNRGHWVSDITFTYLWLLPLIFLTHFFNSFFKFKDIGCKKY
What are the official names of this protein?
Uncharacterized protein MCAP_0865, ORF R6/R7.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROQ_THET2
Sequence: MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQQAHQEGFLAIVLNPGALTHYSYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACRGIVSGFGPLSYKLALVYLAETLEVGGEGF
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: CE10_ECOLX
Sequence: MDKVTDNSPDVESTESTEGSFPTVGVDTGDTITATLATGTENVGGGGGAFGGASESSAAIHATAKWSTAQLKKHQAEQAARAAAAEAALAKAKSQRDALTQRLKDIVNDALRANAARSPSVTDLAHANNMAMQAEAERLRLAKAEQKAREEAEAAEKALREAERQRDEIARQQAETAHLLAMAEAAEAEKNRQDSLDEEHRAVEVAEKKLAEAKAELAKAESDVQSKQAIVSRVAGELENAQKSVDVKVTGFPGWRDVQKKLERQLQDKKNEYSSVTNALNSAVSIRDAKKTEVQNAEIKLKEAKDALEKSQVKDSVDTMVGFYQYITEQYGEKYSRIAQDLAEKAKGSKFNSVDEALAAFEKYKNVLDKKFSKVDRDDIFNALESITYDEWAKHLEKISRALKVTGYLSFGYDVWDGTLKGLKTGDWKPLFVTLEKSAVDFGVAKIVALMFSFIVGAPLGFWGIAIITGIVSSYIGDDELNKLNELLGI
What is the function of this protein?
Colicins are polypeptide toxins produced by and active against E. coli and closely related bacteria.
What are the official names of this protein?
Colicin-10.
What is the protein family that this protein belongs to?
Belongs to the channel forming colicin family.
What are the subcellular locations of this protein?
Host membrane.
Protein: SYR_METCA
Sequence: MKKRLETLLRSALERLKTAGDLPADQEVPLQIERTRDPAHGDFAANTAMLLAKSARCDPRRLAEKIRAALPEDPAVIRTEIAGPGFINFFLDAIAQHRVITDIHSQGPGFGRSSIGAGQRVQVEFVSANPTGPLHVGHGRGAAYGAVVADLLEAAGFDVHREYYVNDAGRQMDILAASVWLRYLENCGEVLPFPANGYRGEYVRDIASDLYRTQGERYRTSADQVLLGLPPDEPQGGDKEEYIDAVVSKSKNLLGPERYREVFNAGLDSILDDIRDDLGEFGTHYQEWFSERSLTETGAVERALERLKSSGYVYEKDGAQWFASTRLGDEKDRVLVRENGQTTYFASDVAYHLNKLERGFDRIVNVWGADHHGYIPRVKAAIQALGGDASKLEVLLVQFAVLYRGTERVQMSTRSGEFVTLRQLRNEVGKDAARFFYVMRKSDQHMDFDLKLATSRTNENPVYYVQYAHARVCSVFRQLDEKGWARDLGRGMRRLERLCEPHELTLVASLSRYPEVVEQAALQYAPHHLVHYLRDLAAEFHGYYNSCQFLVEDGDLRDARLNLIDAVRQVIANGLGLLGVSAPETM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX1A_HETMC
Sequence: ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
What is the function of this protein?
Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1. 1/SCN1A sodium channel (EC(50)=38 nM) (PubMed:27281198, PubMed:30076230).  Also moderately inhibits inactivation of Nav1. 2/SCN2A (EC(50)=236 nM) and Nav1. 3/SCN3A (EC(50)=220 nM) when the channels are expressed in oocytes without the beta-1 auxiliary subunit (PubMed:27281198).  Does not inhibit inactivation of Nav1. 2/SCN2A when the channel is coexpressed with the beta-1 auxiliary subunit (PubMed:30076230).  When tested on Nav1. 1/SCN1A channel, it enhances peak current amplitude and potently delays channel inactivation in a dose-dependent manner, leading to a large sustained current (PubMed:30076230).  It has no effect on the voltage-dependence of steady-state activation, and induces a depolarizing shift in the voltage dependence of inactivation (PubMed:30076230).  In addition, it does not modify the recovery from fast inactivation in Nav1. 1/SCN1A (PubMed:30076230).  The binding affinity and subtype selectivity of the toxin towards Nav1. 1/SCN1A channel is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor of the channel (PubMed:27281198).  This toxin also weakly inhibits several subtypes of voltage-gated potassium channels (PubMed:27281198).  It moderately blocks Kv2. 1/KCNB1 (23% inhibition at 100 nM), Kv2. 2/KCNB2 (19. 7% at 100 nM and 51% at 300 nM), Kv4. 1/KCND1 (IC(50)=280 nM), Kv4. 2/KCND2 (39% at 300 nM) and Kv4. 3/KCND3 (43% at 300 nM) (PubMed:12065754).  In vivo, intracerebroventricular injection into mice elicits convulsions, spasms, tremors and rapid death (PubMed:12065754).  When injected into mouse hindpaw, the toxin elicits an immediate and robust response to pain (PubMed:27281198).  However, intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat, indicative of a modality-specific effect on mechanosensitive neurons (PubMed:27281198).  In Dravet syndrome mice model, intracerebroventricular infusion of this peptide rescues mice from seizures and premature death (PubMed:30076230).
What are the official names of this protein?
Delta-theraphotoxin-Hm1a, Delta-TRTX-Hm1a, Heteroscodratoxin-1, HmTx1, Kappa-theraphotoxin-Hm1a, Kappa-TRTX-Hm1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 09 (HaTx) subfamily.
What are the subcellular locations of this protein?
Secreted.