PharMolix/UniProtQA huggingface dataset:
Protein: HBB1_VARAL
Sequence: VHWTAEEKQLICSLWGKIDVGLIGGETLAGLLVIYPWTQRQFSHFGNLSSPTAIAGNPRVKAHGKKVLTSFGDAIKNLDNIKDTFAKLSELHCDKLHVDPTNFKLLGNVLVIVLADHHGKEFTPAHHAAYQKLVNVVSHSLARRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain, Hemoglobin beta-I chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: BCSE_SALT1
Sequence: MRDTVDPVFSLGISSLWDELRHMPTGGVWWVNADRQQDAISLVNQTIASQTENANVAVIGMEGDPGKVIKLDESHGPEKIRLFTMPDSEKGLYSLPHDLLCSVNPTHYFFILICANNTWRNITSESLHKWLEKMNKWTRFHHCSLLVINPCNNSDKQSSLLMGEYRSLFGLASLRFQGDQHLFDIAFWCNEKGVSARQQLLLCQQDERWTLSHQEETAIQPRSDEKRILSHVAVLEGAPPLSEHWTLFDNNEALFNDARTAQAATIIFSLTQNNQIEPLARRIHTLRRQRGSALKIVVRENIASLRATDERLLLGCGANMIIPWNAPLSRCLTLIESVQGQQFSRYVPEDITTLLSMTQPLKLRGFQPWDTFCDAIHTMMSNTLLPADGKGVLVALRPVPGIRVEQALTLCRPNRTGDIMTIGGNRLVLFLSFCRVNDLDTALNHIFPLPTGDIFSNRMVWFEDKQISAELVQMRLLSPELWGTPLPLAKRADPVINAEHDGRIWRRIPEPLRLLDDTAERAS
What is the function of this protein?
Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) (By similarity).  Required for maximal cellulose synthesis, does not act as a protease on BcsA (PubMed:24942809).
What are the official names of this protein?
Cyclic di-GMP binding protein BcsE, Cellulose biosynthesis protein BcsE.
What is the protein family that this protein belongs to?
Belongs to the BcsE family.
Protein: RSMJ_EDWI9
Sequence: MAAVQLLAEEGADAAALSALAQRWGLCHDADAVLALVLTPQRLELRKLDEPKLGAIFVDFVGGTLAHRRRFGGGRGEAVAKAVGIKGGYLPDVVDATAGLGRDAFVLASLGCRVRMLERHPAVAALLDDGLQRGYADAEIGPWLRERLTLLHASSIEALATLTPRPEVVYLDPMFPHRQKSALVKKDMRVFQALVGADDDADALLAPARRLATKRVVVKRPDYAPPLAGVATPNATLTKSHRFDIYAPLA
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGR1_KLULA
Sequence: MAIYTSGTQSDNSEPVGNDPKFYTRPSLGLKLWGPLVPSSDNTTGLWSLVAIQTGLGLFLMQRFRKLGKKWVKRDIADFPSLNRFSTTHGDMYMTRHIPVQFGGTHSFNIRVGTRTGFWYSERFRTIRRVTYLLAGTLILSQSMLEVSRLTLLKYDPWVEEAKSVREKQFFNDIVKYYHEGVDSTKFKAKDELSGQSISLNLPEVKQSIAVARAQAQAENLVTKWFGPLDYKPQSFSEFLDKLEYYLNMTDFLNNLRRQKKNDKINSQLVKLEEENKRNRQRIHTLMAHAPARAIRTNQEVQDIYAIRKVLLHHDTESPNDIPLTEIWAIYNPWTNLALDTALSIKFFPSVIFNEDYYEHQKRLKDSEHVTSIENSEDERKP
What is the function of this protein?
Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
What are the official names of this protein?
Mitochondrial inner membrane i-AAA protease complex subunit MGR1.
What is the protein family that this protein belongs to?
Belongs to the MGR1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RDRP_INCJH
Sequence: MEINPYLMFLNNDVTSLISTTYPYTGPPPMSHGSSTKYTLETIKRTYDYSRTSVEKTSKVFNIPRRKFCNCLEDKDELVKPTGNVDISSLLGLAEMMEKRMGEGFFKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATALQLTVDAIKETEGPFKGTTMLEYCNKMIEMLDWKEIKFKKVKTVVRREKDKRSGKEIKTKVPVMGIDSIKHDEFLIRALTINTMAKDGERGKLQRRAIATPGMIVRPFSKIVETVAQKICEKLKESGLPVGGNEKKAKLKTTVTSLNARMNSDQFAVNITGDNSKWNECQQPEAYLALLAYITKDSSDLMKDLCSVAPVLFCNKFVKLGQGIRLSNKRKTKEVIIKAEKMGKYKNLMREEYKNLFEPLEKYIQKDVCFLPGGMLMGMFNMLSTVLGVSTLCYMDEELKAKGCFWTGLQSSDDFVLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKSYGSLPELFEFTSMFFDGEFVSNLAMELPAFTTAGVNEGVDFTAAMSIIKTNMINNSLSPSTALMALRICLQEFRATYRVHPWDSRVKGGRMKIINEFIKTIENKDGLLIADGGKLMNNISTLHIPEEVLKFEKMDEQYRNRVFNPKNPFTNFDKTIDIFRAHGPIRVEENEAVVSTHSFRTRANRTLLNTDMRAMMAEEKRYQMVCDMFKSVFESADINPPIGAMSIGEAIEEKLLERAKMKRDIGAIEDSEYEEIKDIIRDAKKARLESR
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: HEM3_STAAE
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL34_MYCAV
Sequence: MAKGKRTFQPNNRRRARVHGFRLRMRNSGRAIVSGRRRKGRRALSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TAT_HV1MA
Sequence: MDPVDPNLEPWNHPGSQPRTPCNKCYCKKCCYHCQMCFITKGLGISYGRKKRRQRRRPPQGNQAHQDPLPEQPSSQHRGDHPTGPKE
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: HRCA_FRUSA
Sequence: MLTERQSMILKYIIDDYSKTGVPIGSKALAEQLPIHVSSATIRNEMAVLSHQNFIEKLHTSSGRVPSNQGYRYYIDNLAKPAKLDTKRLEYISEMLDGSFQQIDEIVRQSADILSHLTDYTALTFSPELTTENTIKHLQLVNLGLNRMMVVIVMGNEQVESQSFLVTNQYIDSQLSLATNLLNQQLVGKTAREVKQVFQSKILTELHTYLPDTKQFVRAIQAILSKIDDDHYFISGQMNMFEQNGKQDFSKIKSLYSMFNNDNGIDALLEKSSKPISVKIGAEFDNDWLKDYSIITGSYDLGNHGIGRIALIGPMRMSYPNMLGVVDAFRHELKNRISGYYRSYDQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: DAAM2_CHICK
Sequence: MAPRKRNRHALGFLCCFGGSDLPEINLKDNNPLQFLDFTVPIPPTEELNARFSELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQTLYAFDEEETEMKNKIVEDLKTALRTQPMRFVMRFIELDGLSCLLNFLKSMDYETSESRIHTSVIGCIKALMNNSQGRAHVLAHPESINIISQSLRTENIKTKIAVLEILGAVCLVPDGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSMGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLREHENATLDRHLDFFEMVRNEDDLELAKRFDLIHIDTKSASQMFELIKKRLKHTDAYPYLLSILQHCLQMPYKRNGGNFQQWQLLDRILQQIVLQDERGDDPDIAPLENFNVKNIIKMLVNENEVKQWRDQAEKFRKDHAELMSKLEKKERECETKTQEKDEMMKTLNKMKDKLQKESLELRQARDQMNDLVAQLNEYSQGGSISFPAPPPPPPGGPLALSSALSSALTSENLPPLPPPLPFSSCPPPPAPPPPPGGPPPPPGAPPFFSLGVPPPSTTTFSSAGTSLKKKSIPQPSHPLKSFNWAKLSEERIHGTIWNEIDDLKAFKVLDLEDFEKMFSAYQRHQKEMGSTEDLYLSTRKVKELSVIDGRRAQNCVILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFVPEKSDTDLLEEHKHEIERMARADRFLFEMSRIDHYQQRLQALFFKKKFPERLAEAKPKVEAILLASKELIRSKRLRQLLEVVLAFGNYMNKGQRGSAYGFKVSSLNKIADTKSSIDRNITLLHYLIMIFEKNYPDILDIQTELQHLPEAAKVNLVELEKEVNNIKTGLKAVEAELDYQKRRIRESGDRFVPVMSDFITVASFSFSELEDLLNDARDKYAKALKHFGENEGKMQPDEFFGIFDTFLQSFAEAKQDLENMRKKKEEEERRARMEAMLKEQREKERRQKKAKAGSISEETGEFDDLVSALRSGEVFDKDLSKLKRNRKRSGNQGLETSRERVVTKLNY
What is the function of this protein?
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822).  Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822).  Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309).  During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822).  Also regulates non-canonical Wnt signaling pathway (PubMed:24091014).  Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014).  Together with DAAM1, required for myocardial maturation and sarcomere assembly (By similarity).
What are the official names of this protein?
Disheveled-associated activator of morphogenesis 2.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
Protein: RBSA2_BURCM
Sequence: MDTILRLSHITKSFPGVKALSDIHLEIVRGEIHALLGENGAGKSTLMKILCGIHQPDAGTIEIDGTARHFTSYHDAVAAGVGIVFQEFSLIPHLDAVDNLFLGRELRTRWGVRDRARMRRAAAGIFARLGVSIDLDAPLRTLSVAQQQFVEIGKALSLDARILILDEPTATLTPAEAEHLFAIMRELKRQGVAMIFISHHLDEIFAVCDRITVLRDGQYVATTDVSSTDVEQLVRMMVGRRLESSFPPKPVRAADAPAVLEVDALQIERDGPVNRFALHAGEILGFAGLVGSGRTETALAVIGATRAHRKTVRVRGTPAKLADPADALRAGIGLLPESRKTEGLVTSFSIRDNISLNNLGKYRSMRWLIDRRGEARTTHDVMRRVGVKAPSIHTEVATLSGGNQQKVVIARWLNHHASVLIFDEPTRGIDVGAKAEIYGLMRELTARGYAIIMISSELPEIVGMCDRVAVFRQGRIEATLEGDEIDPDTVMTHATAGTRGATHEPA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TIG_LEIXX
Sequence: MKTTVEKLSPTRTKLTISVTPEELQPSIKHAYEHIAGQVNIPGFRKGKVPPAIIDQRVGKEAVLEHAVNEGLDGFYRLAVEENEVRPLGRPEADISEWPNEKDFSGDLLLTIEVDVRPEITLPAFDGITLTVEAAQVTPDDVEEELDRLRSRFCTLVTVDRPAKKGDFAQIDLVAEIGGEEVDTAANISYEIGSGELIEGIDEALDTLTAGETTTFEAPLMGGDHEGENAQITVTLNAVKERELPEADDDFAQISSEFDTIGELRESLRGQVERAKSFGQGTAARDQLVEKLLELVEIPVPAQLVEDEVSRHLEQESRLEDDEHRAEVTESSEKTFRTQILLDEIAQRENVKVSQDELTQYLVQGAAQYNMDPNEFVKILGENGQISSMVGEIARNKALAIVLGKAEVVDTNGKQVDLTEFVALPDDGEAVDEDATPEDTDAPAEEAPAAEKPKKKAAAKKKAADK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RS18_BURP0
Sequence: MARPTGKKFDKRRQQQNPLFKRKKFCRFTAAGVEQIDYKDTETLKDFIGENGKITPARLTGTKAHYQRQLDTAIKRARFLALLPYTDQHKA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: GATD_METBU
Sequence: MDFELGDRIRIEKDGNTYEGIVMPSNTDHIVVKMVSGYNAGVDPEGASITLLEKAGPKNAPKAKPDKAKGQKKLPKVTILSTGGTIASKVDYRTGAVTAQFSADDIVDAIPELTEIADINGRVLYNILSENMKAEYWTELAGAVAQEIENGADGIIIAHGTDTMMYSAAALSFMLKTPVPVVFVGSQRSADRPSSDNAMNAICATKVAVSDIAEVCVVMHDTTSDDRCAIHFGTKVRKMHTSRRDAFQSINSDPIGYIDHSTHKIETVLPFSKRDSQKLELKNTLEPKCSLVKFVPGANPDVLSYYIDSGYKGLVIEGTGLGHVSTDWIPNIKRATENGIPVIMTSQCISGRVCDRVYDTGRDILKAGAIEGEDMLPEVALVKLMWALGQSNDVDEIKEIMRSNIGHEMTDSTLK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: DTD_ALTMD
Sequence: MIGLIQRVSEANVTVAGEVIGEIGKGMLVLLGVEKEDGDAEIEKLANKLCRYRMFSDEDGKMNLNIEQVGGEILVVSQFTLVADTQKGNRPGFSRGATPEHGEAIYKKFVHALRAKGMAVSTGEFGADMQVGLVNDGPVTFHFNV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBB2_RAT
Sequence: MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell membrane.
Protein: RPOB_STRGC
Sequence: MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKDFLDHGLKEVFEDVLPISNFTDTMELEFVGYEIREPKYTLEEARIHDASYSAPIFVTFRLINKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKIGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSDLVRNTIEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPHRYDLAAVGRYKINKKLNIKTRLLNQTIAEPLVDAETGEILVEAGTLMTRSVIDSIAEQLDNGLNKITYIPNDSAVLTEPVELQKFKVVAPTDPDRVVTIIGNANPSDKVRTVTPADILAEMSYFLNLAEGIGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQQIINIRPVTAAIKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFIQTPYRKVDREAGVVTNEIVWLTADEEDEFIVAQANSKLNEEGGFAEPIVMGRHQGNNQEFPSDQVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQHDGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIADGPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDTKLGPEEITREIPNVGEDALRNLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGASSDDLWDTVREAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSMVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVNGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVELRDLDEGEDDDVIHVDDLEKAREKAAQEAKAAFEAEGKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: HISZ_PSEAE
Sequence: MATVDRWLLPDGIEEVLPPEAARIEAARRQVLDLFHRWGYEFVVTPHIEYLESLLTGAGQDLDLRTFKVTDPASGRLMGFRADITPQVARMDAHSLRREGPSRLCYAGSVLHAQPRALSTSRSPIQLGAELYGDPSPASDVEVISLMLEMLEMAEVPDVHMDLGHVGIYRGLARAAGLSGEVEQQLFDALQRKAVDEVEALTADLPAELRGMLRALAELCGGRDALEQGRARLAAAPADVQVALNELIEIADSLAGRFPGLPLYFDLGELRGYHYHTGVVFAAFVPGVGQSIAQGGRYDDIGADFGRARPATGFSTDLKSLVTLGQARLDQAVSGIWAPAEGAGLWQAVQRLRRDGQRVVQALPGQDAASAREAGCDRQLALRDGNWQVAPLAS
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CAMHC
Sequence: MNNFAKRIIPCLDVNNGRVVKGVNFVNLIDAGDPVEVAKIYNDSGADELCFLDITASFENRDTIVEVVRNVASELFIPLTVGGGIRKIDDISRLLEAGCDKVSINSAAIKNPNFIDEAAKKFGSQCIVVAIDAKKTDQGYHVFINGGRVDTKIDVFSWSKEVENRGCGEILLTSMDRDGTKSGFDNYLTGKVSKSLGIPVIASGGAGCMEHIRDTFLAGADAALAASIFHFGEIKIDDLKRYLRTQNIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPA_SALA4
Sequence: MKKTAIALLAWFVSSASLAATPWQKITHPVPGAAQSIGSFANGCIIGADTLPVQSDNYQVMRTDQRRYFGHPDLVMFIQRLSHQAQQRGLGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWSQAQLLRPQALDLVSRDGKHVVPSRWSSDIASLIKLAAQDNDVTRIFVNPAIKQQLCLDAGNDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVL
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RPPH_AZOSB
Sequence: MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGLRPEHVKILGRTRGWLRYDVPKHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPEFDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKPAELPEGYRQGTASQA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: NTF4_RAT
Sequence: MLPRHSCSLLLFLLLLPSVPMEPQPPSSTLPPFLAPEWDLLSPRVALSRGTPAGPPLLFLLEAGAYGEPAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKAESAGEGGPGVGGGGCRGVDRRHWLSECKAKQSYVRALTADSQGRVGWRWIRIDTACVCTLLSRTGRA
What is the function of this protein?
Could serve as a target-derived trophic factor for sensory and sympathetic neurons.
What are the official names of this protein?
Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL25_PARUW
Sequence: MKAILRTGKSKSEINRLRREGMIPAVLYVRGKEGETLAINSAEFNSYLRHVKSGHLPTTIFTLVDEKGSERRVLVKDIQYAITTYQVMHLDFEELIDDHKINVKVPIECTGTVDCVGVKLGGVLRQVIRHARIRCLPKDMPSFFELDVQELGLKQSKRLKDMNIPETVRPLIDMNEVVAVIVKR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL4_PSEPW
Sequence: MQLNVNDAQAIEVSELTFGGEFNETLVHQAVVAYMAGGRQGTKQQKTRSDVAGGGKRPWRQKGTGRARAGTTRGPIWRGGGVTFAARPQDHSQKLNKKMYRAALRSILAELVRSDRLVVVQDFAVEAPKTKDLLNKLNGMGLSDVLIVSDAVDQNLYLAARNLPHVDVRDVQGSDPVSLIAYEKVLITVSAVKKFEELLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: COMD6_XENTR
Sequence: MFDRELEAFGFEKTDDLIKIVPPDLFAELCQQSVQHLQRQRSGVDCQVIFQSFQAAGVLISEDELRKIIRWITTLFSTAAKYNVTCEELLSRLISKLPKQILQVIRHVWNEEGKRLSELEKSRDLLPSGELVDFQWKIGMAVSSDSCRSLNHPYVTIELKVADYSGQITSKVFELTIPEFQNFHKQVKEMSSVLETV
What is the function of this protein?
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes.  Inhibits TNF-induced nfkb1 activation.
What are the official names of this protein?
COMM domain-containing protein 6.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.