PharMolix/UniProtQA huggingface dataset:
Protein: LY96_CRIGR
Sequence: MLPFILFSTLLPLIFTESEQQLWFCNSSDATFSYSYCDSMKFPFSITAEPCITLKGTNGFLHIKFIPRRDLKKLYFNLSINVNSIEVPTRKEIICHGYDDNYSFCKALKGETVNTVVPFSFKGILFPKGQYRCVAEAIVGDNEEKLFCLNFTIIHHPNVN
What is the function of this protein?
Binds bacterial lipopolysaccharide (LPS).  Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria.  Enhances TLR4-dependent activation of NF-kappa-B.  Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS.
What are the official names of this protein?
Lymphocyte antigen 96, Ly-96, Protein MD-2.
What are the subcellular locations of this protein?
Secreted, extracellular space. Secreted. Note=Retained in the extracellular space at the cell surface by interaction with TLR4.
Protein: R1441_DANRE
Sequence: MTTARYRPTWDLALDPLVSCKLCLGEFPLEQMTTITQCQCVFCTMCLKQYVELLIKEGFETAISCPDSACPKRGHLQENEIECMVATEIMQRYRKLQFEKEVLLDPSRTWCPSSTCQAVCQLKESDTVLPQLVRCSVCTLEFCSACKASWHPDQDCQENVPITSFLPGESSSFFKADDDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVLCCKCKCSKGDDDPLPT
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase RNF144A-A, RING finger protein 144A-A.
What is the protein family that this protein belongs to?
Belongs to the RBR family. RNF144 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RR4_CYAPA
Sequence: MSRYKGPSLRIIRRLGELPGLTRKVVKKRKYPPGQHGQKSRKRSEYAIRLEEKQKLRYNYGLTERQLVQCVRRAKQMKGSTGQILLQLLEMRLDNIVFRLGMAPTIPASRQLVNHGHICVNNKVVSIPSYQCKPGDIITVKERNASKKIVETNLLFPGLANLPSHLEFDKSKLQGKVNDIIQREWVALEVNELLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
Cyanelle 30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: RL28_NATTJ
Sequence: MANLCEICGKGNNSGASVSHSNKKTKRKWKGNIQKLKAMVDGRPKKVKVCTQCIKAGKIERAF
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RL10_BORAP
Sequence: MSTKINSKKLEMFDLLKKFIDSKQNIFFLDYRGLSVSQLTDLRNKIEGEHGALKVVKNNIMKMVLKEKNIDVVDSCLVGPTVVVTALEEANVIAKIFYDFVKTTTLKVKGGFVLGEFYDEAKVQAYSKLPTKKESISLFASVLKAPVSKLVRTLKALADVKN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SEPF_KINRD
Sequence: MAGALRNAMVYLGLAEDDRYAEDTEPETTRPRVEAAREVRVESRHEARPEVRHEPRPEVSVERRPAPATTAQVTPIRKQVAHVVPQTSTTSSSPELHRITTIHPRTYNEAKTIGESFREGVPVIMNLTDMDDSDAKRLVDFSAGLVFGLHGAIERVTNKVFLLSPANVEVASQEEERPTERTFFNQS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RELA_STREQ
Sequence: MAKEINLTGEEVVALAAKYMNETDAAFVKKALDYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDNIEFDFGKDVRDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMNEKRREREALVDDIVTKIKSYTTEQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAAHWAYKKGVRGKVNQAEQKVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKDSGPIDFAYAIHTQVGEKAIGAKVNGRMVPLTAKLKTGDVVEIVTNPNSFGPSRDWIKLVKTNKARNKIRQFFKNQDKELSVNKGRDMLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPVSVFNKLTEKERREEERAKAKAEAEELVNGGEIKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIEGYITKGRGIAIHRADCNNIKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRRGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes both the formation of pppGpp which is then hydrolyzed to form ppGpp, and the hydrolysis of ppGpp.  The enzyme does not simultaneously display both synthase and hydrolase activities.  In the structure of residues 1-385 there are 2 conformations seen, the hydrolase-OFF/synthase-ON and hydrolase-ON/synthase-OFF, suggesting there is ligand-induced signal transmission between the 2 active sites.
What are the official names of this protein?
Bifunctional (p)ppGpp synthase/hydrolase RelA.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: HIS3_DELAS
Sequence: MQAMNWLDQVKWDAQGLVPVIAQEKDTGDVMMFAWMNREALAKTAELGRAVYFSRSRNKLWFKGEESGHVQTVHEVRIDCDNDVVLLKITQTGHEPGIACHTGRHSCFYSVLRDGQWQAVDPVLKDPESIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE2_PHOPR
Sequence: MAIGVTQNTFQLNIVSAEGPLFSGKAHALAISGLDGELGIRPGHSPLLSRIKPGVAYFQTDLKGDDEILYISGGILEVQPSLVTVLADTAMHGKDIDEARANEARRAAEENINKQGNDINFAQAQMDLAKAMAQLRAVELTQKQRRR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain 2, ATP synthase F1 sector epsilon subunit 2, F-ATPase epsilon subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1204_ENTFA
Sequence: MTEHNHDHDHEGHEHITLVDEQGNETLYEILLTVDGQEEFGKNYVLLYPAGIPEDEDVELQAYSYVENAEGTEGDLQQIETDAEWDMIEEVFNTFMAEEEE
What are the official names of this protein?
UPF0473 protein EF_1204.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: CT5B_CONTE
Sequence: KPCCSIHDSSCCGI
What are the official names of this protein?
Conotoxin tx5b, Conotoxin 1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ZBTB5_HUMAN
Sequence: MDFPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFSVAEGDQTMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKRKQSAEERARQRLRPSIDESAISDVTPENGPSGVHSREEFFSPDSLKIVDNPKADGMTDNQEDSAIMFDQSFGTQEDAQVPSQSDNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLGEKEHMRVVVKSEPLSSPEPQDEVSDVTSQAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEHKSTFSISNFLNKSRGNNFTANQNNDDNIPNTTSDCRLESEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPADSHFVRPMQEVMGLPCVQTSGYQGGEQFGMDFSRSGLGLHSSFSRVMIGSPRGGASNFPYYRRIAPKMPVVTSVRSSQIPENSTSSQLMMNGATSSFENGHPSQPGPPQLTRASADVLSKCKKALSEHNVLVVEGARKYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHSKTTCLRWQSSNLPSTLL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 5.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_TRYCR
Sequence: MGKEKANVKGCRFRVSLALPVGAVVNCADNTGAKNLYIISVKGYHGRLNRLPAAALGDIVMASVKKGKPELRRKVLNAVIIRQRKSWRRKDGTVIYFEDNAGVIVNSQGRDGRVSGIAGPVAKEAGRPSGPKISSHAPAIV
What are the official names of this protein?
60S ribosomal protein L23, L17, TCEST082.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PR28_MYCTU
Sequence: MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR
What are the official names of this protein?
Proline-rich 28 kDa antigen.
What is the protein family that this protein belongs to?
To M.leprae ML0031.
Protein: NSP3_ROTHS
Sequence: MLKMESTQQMASSIINSSFEAAVVAATSTLELMGIQYDYNEVYTRVKSKFDFVMDDSGVENNLMGKAATIDQALNGKFSSSIRNRNWMTDSKTVARLDEDVNKLRLLLSSKGIDQKMRVLNACFSVKRVPGKSSSVIKCTRLMKEKIERGEVEVDDTFIEERMEIDTIDWKSRYDQLERRFESLKQRVNEKYNNWVIKARKVNENMNSLQNVISQQQAHINELQIYNNKLERDLQSKIGSVISSIEWYLRSMELSDDIKSDIEQQLNSIDLINPVNAFDDFESILRNLISDYDRIFIMFKGLLQQSNYTYTYE
What is the function of this protein?
Plays an important role in stimulating the translation of viral mRNAs.  These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding.  The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
What are the official names of this protein?
Non-structural protein 3, NSP3, NCVP4, Non-structural RNA-binding protein 34, NS34.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP3 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: FIS_ESCF3
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: ENO_BORBZ
Sequence: MGFHIYEIKARQIIDSRGNPTVEADVILEDGTYGRAAVPSGASTGINEAVELRDGDKSVYMGKGVLKAIENIKNIIAPELEGMSALNQVAIDRKMLELDGTPTKEKLGANAILAVSMATAKAAAKYLGLRPYQYLGAYKANILPTPMCNIINGGAHSDNSVDFQEFMIMPIGAKTFSEAIRMAAEVFHTLKGILSGKGYATSVGDEGGFAPNLKSNEEACEVIIEAIKKAGYEPGKDIAIALDPATSELYDPKTKKYVLKWSTKEELTSEQMVEYWAKWVEKYPIISIEDGMAEEDWDGWKKLTDKIGNKIQLVGDDLFVTNTSFLKKGIEMGVANSILIKVNQIGTLTETFEAVEMAKKAGYTAIVSHRSGETEDTTIADLVVALGTGQIKTGSLSRTDRIAKYNQLIRIEEELETTAEYHGKSVFYSIKQK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: GP7_BPSPP
Sequence: MPEPQNQEELDKYLDNIITQAEKRLDKVFASRLKEIKAMINKLFEKYSKNGELTYADVVKYNRLEKEMDVIKQNISADYKTVLKMLNELLETQYVDNYLRSAYIYEMYTGRNLGFSVPSADVVQRAVENPIPLLTLPKVLERQRVELINNIAMAIAQGLMAGEGYSQVAQRVHKRMQLSLAKARLTARTEGHRVQVAGRMASAEQAAKKVNMQKMWSAALDTRTRAGHRKLDGKIINMDENFKSIYGGVGKAPGHMHMAKDDCNCRCALIYVIDGEIPSVRRARLSDGSTRVIKYIPYTEWEKQKKAS
What is the function of this protein?
Binds the viral DNA inside the capsid and the portal protein.  May control the DNA exit from the virion.
What are the official names of this protein?
Minor head protein GP7, Accessory head protein gp7.
What are the subcellular locations of this protein?
Virion. Note=Probably located next to the portal vertex. Present in one to two copies per virion.
Protein: RS7_PSYCK
Sequence: MPRRRVVATREILPDPKFGSQTVAKFINHVMSHGKKSTAERIVYGALETVSQKRNIEDPVSFFEEVLENVRPMVEVKARRVGGATYQVPMEVRPSRRTALAMRWLAEAAAKRSEKSMALRLAGELNDAADGKGNAMKKRDEVHRMADANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MINC_RUMCH
Sequence: MDENSVTFKGTVNGLTIILKNEPEFSEIIQCMRDKVNSAGKFFRGAKLAVKYKGRILNEEERSQLLEILVRESGARIEAFEEDKEQVQNVANNVSSDKPVERKNQIKKYMFFKGIEEGQTKFYRGTVRSGQLVNFDGNLVILGDVNPGAVIEATGNIVVMGLLRGVVHAGSDGNKEAIVVALGLNPTQLRIADIITRPPDEKGVVGNPIPELAYVKDDILYVERFLPTR
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: EFTS_CAUSK
Sequence: MAEVTAALVKELREKSGVGMMDCKKALVENNGDIDASIDWLRAKGLSKAAKKADRVAAEGLVGIVVRAEGAGMIAAAVEVNAETDFLSRNELFQTAVRKIARAGLDNEGVEAISAAKTPDGEVVSDLLTHLIATIGENMVLRRSARFAVAHGAVASYIHNATAPDLGRIGVLVAIEGAGDQTKILELGRKIAMHVAATAPLSLSPDDLDQAAIEKERQIFTEQALESGKPPAVVEKMVEGRIRKFLEEVVLLKQAFVMNPDQTVEQLVAEAGKELGSPLTVKGFVRLALGEGVEKGPEGDFAAEVAAMTGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAC_ECOLI
Sequence: MNLDDIINSMMPEVYQRLSTAVELGKWPDGVALTEEQKENCLQLVMLWQARHNIEAQHMTIDTNGQMVMKSKQQLKEDFGISAKPIAMFK
What are the official names of this protein?
Uncharacterized protein YeaC.
Protein: U6B_CONPI
Sequence: FGSFIPCAHKGEPCTICCRPLRCHEEKTPTCV
What is the function of this protein?
Intraperitoneal injection into fish (0. 5 nmol) provokes vertical suspension and paralysis after 6 min.
What are the official names of this protein?
Conotoxin pr6b.
What are the subcellular locations of this protein?
Secreted.
Protein: NUON2_KORVE
Sequence: MSNFQFAIPTIDYIRILPEIVLAVFGIVVMMADALIPQNNSKKPLGYLSLIGVLVSLGAIACQARYPGMYDVNNGTGFWGMVHVDSFSLFFHVLIALITAAVLLVSFEYMDVQRMRSGEYYAIILFSALGMMLMTSATELVLIFIALEISSIGSYVLAAMRRRVAESAESSLKYFLLGSFATAFFLYGVALIFGATGSTNVYTIAAALQNMHPLQPIIYLAVALMFIGLGFKVAAAPFHVWTPDVYEGAPSPIVALMSTGPKAAAFAVLLRVLFAMNAPGWFWIVWVSAALSMTIGNIGALVQSNVKRLLAYSSIAHAGYMLVAFAAAKDAGISAAIFYTATYAAMNVGAFAVVSHFANTGEKYVTLEDYAGLGRRSPLLAAILTVFLLSLIGIPVTGGFFAKFYVFTSALQSHLVWLTIIGVINSAVGAYYYLRIIVYMYMRDEREEVPVARMPFGLALALAMCLMFTIYLGVLPTQFINYALKSAQDLVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N 2, NADH dehydrogenase I subunit N 2, NDH-1 subunit N 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MIP_DROME
Sequence: MAHTKTRRTYGFLMVLLILGSACGNLVASGSAGSPPSNEPGGGGLSEQVVLDQLSESDLYGNNKRAWQSLQSSWGKRSSSGDVSDPDIYMTGHFVPLVITDGTNTIDWDTFERLASGQSAQQQQQQPLQQQSQSGEDFDDLAGEPDVEKRAWKSMNVAWGKRRQAQGWNKFRGAWGKREPTWNNLKGMWGKRDQWQKLHGGWGKRSQLPSN
What is the function of this protein?
Ligand for the sex peptide receptor (SPR) (PubMed:20308537, PubMed:20458515, PubMed:25333796).  Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons.  Regulated by the circadian clock network and pathways associated with a sleep homeostat (PubMed:25333796).  May also have a regulatory role in gut motility (PubMed:11181081).
What are the official names of this protein?
Allatostatins MIP, B-type Allostatin preprohormone, Myoinhibitory-like protein.
What are the subcellular locations of this protein?
Secreted.
Protein: S2538_COCIM
Sequence: MSNGSHSSVQLKSSTYLSKPTFHFAAGLLSGLTSSILLQPADLLKTRVQQSRETAALLPTIRSILASPHPIQGLWRGTLPSALRTGFGSALYFTSLNTLRTAVAADDPGYLFRGGHGSKPQNGNSPSGVSASSALPKLSHTANLITGAVARVAAGFVMMPVTVLKVRYESDYYAYRSLWGAAKDIVRHEGVRGLFAGFGATAIRDAPYAGLYVVFYEQSKRSLASLLGASSPSARSTPTEQQKSPPSTASINFISGALAAGLATTITNPFDVVKTRVQLMPSKYKNMMRATALMLREDGMRSLFGGLGLRMGRKALSSALAWTVYEELIMWAEKRWAEEQRDVKGVL
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CXCR2_RAT
Sequence: MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKLIKETCERQNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEGRPSFVGSSSANTSTTL
What is the function of this protein?
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor.  Binding of IL-8 to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.  Binds to IL-8 with high affinity.  Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
What are the official names of this protein?
C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_GLOVI
Sequence: MRILVSNDDGILAQGIRTLANTLHRAGHTVTVVCPDRERSATGHALTMHKPLRAEAVENLFEPGLAAWAINGTPSDSVKLGLDALLGERPDLVVSGINCGANLGSDVLYSGTVSAAMEGTIEGLPSIAVSLASRVRCDFQPAADFLVRFVRALEVQPLPEAFLLNVNVPALPESEILGARVCRLGMRRYRDQFVKRVDPRGVNYYWLAGEVIESEEAPDSDVVAVGEGCIAITPLKYDLTYEPGIGLLGARQWEKIFDPLAGG
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG_HELHP
Sequence: MVKIGICGPVGSGKTALIESLTRKMNEQYSLAVITNDIYTQEDAEFMSKNSVLPSERIIGVETGGCPHTAIREDASMNLEAVEEMQERFPDIEILFIESGGDNLSATFSPELADFTIFVIDVAQGDKIPRKGGPGIMRSDLLIINKIDLAPYVGANLSIMERDAKKMREDKPFLFTNIRAKEGIDAVVEWIKKYALLEDI
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_BRUA4
Sequence: MSGELNGNDTPTQAAMPAVGVPESVAFAEDAEQHNESMKTLVLGALGVVYGDIGTSPIYAFREALHAAASDGILARSDILGVVSLIFWALTLVVTIKYVLFVLRADNNGEGGILSLMALVRGALKGRPDLILGVGICGAALFFGDAVITPAISVLSAMEGLEIVAPDLTPFVVPITVVILVTLFSVQKLGTGKVAIVFGPIMALWFLALGASGLWHIFDDPTVMVALNPYYAVRFLMISPGIAFITVGAVFLAMTGAEALYADLGHFGRKPIVRAWLWIVFPCLLLNYFGQAAFILSHGEAAALPFFQMMPSFALLPMVLLATAATVIASQAVITGAYSVARQAVQLNILPRLEIQHTSEKLHGQIYIPRVNLLLGLAVVILVLGFEKSSNLAAAYGIAVTGNMLVTTVLLYIVMTRIWNWRVSRALPIIVGFLIIDIMFFGANIIKVHEGGWASIGIAAILVLIMWTWVRGTRHLFNKTRKAEVPLDLIVQQMTKRPPTIVPGTAVFLTGDPKSAPTALMHSLKHYKVLHENNVILTVVTASKPWVSSADRARVSQYNERFMQVTLTFGYMQQPNIPRALGICRKLGWKFDIMTTSFFLSRRSLKASAHSGLPLWQDKLFILLARTASDATEYFQIPTGRVVEIGTQVNL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DDL_NITSB
Sequence: MQYAVVFGGKSYEHEISIVSTIAIKDIIPGAIFIFLDGNRDFYLIEKADLKSNYFSSGNYKKSPKLELKKGGFYQKSLLKEKKIPADVVINLVHGADGEDGKLASLLEFFEIDYIGPRIEGSVISYSKLLTKLYAKECGIEVLPYQLLRKQDKKIIDFEYPVIIKPNHLGSSIGVSVVYDSSELEYALDVAFEFDDEVLIEPFIEGIEEYNLAGAKGQTFHFSKIEAVKKEKLLDFEKKYLDFGRSGEVKDASLNETLRLHIRNAFEKIYDPLFSGAIIRIDFFVRDGKLYLNEINPVPGSLANYLFGDFRAVLEDVAKHLPKSKNIVIDYRYINSIQSAKK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPC2_HUMAN
Sequence: MSALRPLLLLLLPLCPGPGPGPGSEAKVTRSCAETRQVLGARGYSLNLIPPALISGEHLRVCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEFFLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHPQYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSEALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLSSRGLEPDWGNYLDGLLILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPPDPVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAADASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATARMKTAALGHDLDGQDADEDASGSGGGQQYADDWMAGAVAPPARPPRPPYPPRRDGSGGKGGGGSARYNQGRSRSGGASIGFHTQTILILSLSALALLGPR
What is the function of this protein?
Cell surface proteoglycan that bears heparan sulfate.  May fulfill a function related to the motile behaviors of developing neurons (By similarity).
What are the official names of this protein?
Glypican-2.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. SUBCELLULAR LOCATION: [Secreted glypican-2]: Secreted, extracellular space.
Protein: CUTC_SHIF8
Sequence: MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLYTLNNLAELGIARVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDEHADEYSRYIVDGAAVAEMKGIIERHQAK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.