PharMolix/UniProtQA huggingface dataset:
Protein: VP7_ROTHP
Sequence: MYGIEYTTVLTFLISVILLNYVLKSLTRIMDFIIYRFLLIIVILSPLLNAQNYGINLPITGSMDTPYTNSTREEVFLTSTLCLYYPTEAATEINDNSWKDTLSQLFLTKGWPTGSVYFKDYTDIASFSVDPQMYCDYNLVLMKYDATLQLDMSELADLLLNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDTNTFEEVATAEKLVITDVVDGVNHKLNVTTNTCTIRNCKKLGPRENVAVIQVGGSDVLDITADPTTMPQTERMMRVNWKKWWQVFYTIVDYVNQIVQAMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: PMT4_TOBAC
Sequence: MEVISTNTNGSTIFKNGAIPMNGHQSGTSKHLNGYQNGTSKHQNGHHNGTSEHRNGHQNGISEHQNGHQNGTSEQQNGTISHDNGNELLGNSNSIKLGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPTIEKIDIVEIDDVVVDVSRKSFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPINPIDKETTQVKSKLAPLKFYNSDIHKAAFILPSFARSMIES
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (PubMed:10598105, PubMed:31276744, PubMed:34095742).  Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (PubMed:10598105).  Promotes leaves ripening (PubMed:34095742).
What are the official names of this protein?
Putrescine N-methyltransferase 4, NtPMT4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Putrescine methyltransferase family.
Protein: UBID_EDWI9
Sequence: MKYRDLREFIALLEQRGELKRIQQSIDPYLEMTEIADRTLRVGGPALLFENPKGYDIPVLCNLFGTPQRVALGMGQEEVGALRDVGKLLAFLKEPDPPKGFRDLVEKLPQFKQILNMPTKRLSKAPCQEQVLQGDDVDLATLPVMHCWPQDVAPLVSWGLTVTRGPCKSRQNLGIYRQQVLGKNKLIMRWLSHRGGALDFQDWCQAHPGERFPVAVALGADPATLLAAVTPVPDSLSEYAFAGLLRGHKSEVVKCLSCDLEVPASAEIVLEGYIEPGETAPEGPYGDHTGYYNEVERFPVFTVTHLTQRDRPIYHSTYTGRPPDEPAVLGLALNEVFVPLLQKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKFVIVCDDDINARDWQDVIWALTTRMDPARDTLLIENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGHPIVMDEAVRARVDTLWNELDIFANDKDAQ
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRXM2_ARATH
Sequence: MAAFTCTSRPPISLRSETRIVSSSPSASSLSSRRMFAVLPESSGLRIRLSLSPASLTSIHQPRVSRLRRAVVCEAQETTTDIQVVNDSTWDSLVLKATGPVVVDFWAPWCGPCKMIDPLVNDLAQHYTGKIKFYKLNTDESPNTPGQYGVRSIPTIMIFVGGEKKDTIIGAVPKTTLTSSLDKFLP
What is the function of this protein?
Thiol-disulfide oxidoreductase that may participate in various redox reactions.  May activate NADP-malate dehydrogenase.
What are the official names of this protein?
Thioredoxin M2, chloroplastic, AtTrxm2.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant M-type subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RGI5_ARATH
Sequence: MERERSNFFFLFLFCSWVSMAQPTLSLSSDGQALLSLKRPSPSLFSSWDPQDQTPCSWYGITCSADNRVISVSIPDTFLNLSSIPDLSSLSSLQFLNLSSTNLSGPIPPSFGKLTHLRLLDLSSNSLSGPIPSELGRLSTLQFLILNANKLSGSIPSQISNLFALQVLCLQDNLLNGSIPSSFGSLVSLQQFRLGGNTNLGGPIPAQLGFLKNLTTLGFAASGLSGSIPSTFGNLVNLQTLALYDTEISGTIPPQLGLCSELRNLYLHMNKLTGSIPKELGKLQKITSLLLWGNSLSGVIPPEISNCSSLVVFDVSANDLTGDIPGDLGKLVWLEQLQLSDNMFTGQIPWELSNCSSLIALQLDKNKLSGSIPSQIGNLKSLQSFFLWENSISGTIPSSFGNCTDLVALDLSRNKLTGRIPEELFSLKRLSKLLLLGNSLSGGLPKSVAKCQSLVRLRVGENQLSGQIPKEIGELQNLVFLDLYMNHFSGGLPYEISNITVLELLDVHNNYITGDIPAQLGNLVNLEQLDLSRNSFTGNIPLSFGNLSYLNKLILNNNLLTGQIPKSIKNLQKLTLLDLSYNSLSGEIPQELGQVTSLTINLDLSYNTFTGNIPETFSDLTQLQSLDLSSNSLHGDIKVLGSLTSLASLNISCNNFSGPIPSTPFFKTISTTSYLQNTNLCHSLDGITCSSHTGQNNGVKSPKIVALTAVILASITIAILAAWLLILRNNHLYKTSQNSSSSPSTAEDFSYPWTFIPFQKLGITVNNIVTSLTDENVIGKGCSGIVYKAEIPNGDIVAVKKLWKTKDNNEEGESTIDSFAAEIQILGNIRHRNIVKLLGYCSNKSVKLLLYNYFPNGNLQQLLQGNRNLDWETRYKIAIGAAQGLAYLHHDCVPAILHRDVKCNNILLDSKYEAILADFGLAKLMMNSPNYHNAMSRVAGSYGYIAPEYGYTMNITEKSDVYSYGVVLLEILSGRSAVEPQIGDGLHIVEWVKKKMGTFEPALSVLDVKLQGLPDQIVQEMLQTLGIAMFCVNPSPVERPTMKEVVTLLMEVKCSPEEWGKTSQPLIKPSSS
What is the function of this protein?
Together with RGI1, RGI2, RGI3 and RGI4, acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT) (PubMed:27229312, PubMed:27229311).  Links RGF1 signal with its downstream components (PubMed:27229311).
What are the official names of this protein?
LRR receptor-like serine/threonine-protein kinase RGI5, Protein RECEPTOR OF RGF1 5, Protein RGF1 INSENSITIVE 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NRN1_RAT
Sequence: MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPALSVLLVSLSAALATWLSF
What is the function of this protein?
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
What are the official names of this protein?
Neuritin.
What is the protein family that this protein belongs to?
Belongs to the neuritin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Synapse.
Protein: RBFA_STRPC
Sequence: MANHRIDRVGMEIKREVNDILQKKVRDPRVQGVTITEVQMQGDLSLAKVYYTIMSDLASDNQKAQTGLEKATGTIKRELGKQLTMYKIPDLVFEKDNSIAYGNKIDQLLRELDNKS
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_PSEPW
Sequence: MSQPTPAVRTFQDLILALQNYWAAQGCVVLQPYDMEVGAGTFHTATFLRAVGPETWNAAYVQPSRRPADGRYGENPNRLQHYYQFQVVLKPNPANFQELYLGSLKAIGLDPLVHDIRFVEDNWESPTLGAWGLGWEIWLNGMEVTQFTYFQQVGGIECYPVTGEITYGLERLAMYIQGVDSVYDLVWADGPFGKVTYGDVFHQNEVEQSTYNFEHANVEKLFELFDFYESEANRLIKLDLPLPTYEMVLKASHTFNLLDARRAISVTERQRYILRVRTLARDVAQSYLQARARLGFPMATPELRDEVLAKLEAAQ
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF7_BFDV
Sequence: MFNSVSLPLTIPALNKDSDSKYLFECLLAPSALTVFVVSGGPPGAPPPTQNTPSGLVGLSGLTALRALRQGVPPCGIGPSARRLAL
What are the official names of this protein?
Uncharacterized protein ORF7.
Protein: YDHW_ECOLI
Sequence: MGKMNHQDELPLAKVSEVDEAKRQWLQGMRHPVDTVTEPEPAEILAEFIRQHSAAGQLVARAVFLSPPYLVAEEELSVLLESIKQNGDYADIACLTGSKDDYYYSTQAMSENYAAMSLQVVEQDICRAIAHAVRFECQTYPRPYKVAMLMQAPYYFQEAQIEAAIAAMDVAPEYADIRQVESSTAVLYLFSERFMTYGKAYGLCEWFEVEQFQNP
What are the official names of this protein?
Uncharacterized protein YdhW.
Protein: DSO1_DROME
Sequence: MKFFQAAALLLAMFAALANAEPVPQPGTVLIQTDNTQYIRTG
What is the function of this protein?
Peptide which plays a role in the humoral immune response to a subset of filamentous fungi, including F. oxysporum and F. verticillioides.
What are the official names of this protein?
Daisho1, Immune-induced peptide 4, DIM-4.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_RHIE6
Sequence: MALKIRLARGGSKKRPYYHVVLADARSPRDGRFLENLGSWNPMLAKDDEKRVQLNAERIKHWLDNGAQPTDRVLRFLNEAGVAKREAKNNPIKAKPGKRAQERAAEKAQKAADAAAAAADAAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HNF6_RAT
Sequence: MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSHLPPAHPRSMGMASLLDGGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNDFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
What is the function of this protein?
Transcriptional activator.  Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.  Important for liver genes transcription.  The affinity of HNF-6-alpha and HNF-6-beta for DNA differs depending on the target sequence.
What are the official names of this protein?
Hepatocyte nuclear factor 6, HNF-6, One cut domain family member 1, One cut homeobox 1.
What is the protein family that this protein belongs to?
Belongs to the CUT homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAC79_ARATH
Sequence: METFGVFHKEDDEQMDLPPGFRFHPTDEELITHYLHKKVLDLGFSAKAIGEVDLNKAEPWELPYKAKIGEKEWYFFCVRDRKYPTGLRTNRATQAGYWKATGKDKEIFRGKSLVGMKKTLVFYRGRAPKGQKTNWVMHEYRLDGKLSAHNLPKTAKNEWVICRVFHKTAGGKKIPISTLIRIGSYGTGSSLPPLTDSSPYNDKTKTEPVYVPCFSNQAETRGTILNCFSNPSLSSIQPDFLQMIPLYQPQSLNISESSNPVLTQEQSVLQAMMENNRRQNFKTLSISQETGVSNTDNSSVFEFGRKRFDHQEVPSPSSGPVDLEPFWNY
What are the official names of this protein?
NAC domain-containing protein 79, ANAC79, ANAC80, AtNAC79, AtNAC80.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPP23_HAEIF
Sequence: MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSIITEQSNSTVDDQEQQHGALRNAGSRFHIKATHNFGDGFYAQGYLETRLVSDYPESSSDHFGGITTKYAYVTLGNKAFGEVKLGRAKTIADGITSAEDKEYGVLNNKKYIPTNGNTVGYTYKGIDGLDGLVLGANYLLAQSRVPGGPSPFPRKQGEVYPQQISNGVQVGAKYDANNIIAGIAFGRTNYKTAGADFDPYGDFGLGRKEQVEGVLSTLGYRFSDLGLLVSLDSGYAKTKYYTTTDSSSGSQTITNPAYDEKRSFVSPGFQYELMEDTNVYGNFKYERTSVNQGKNTREQAVLFGVDHKLHKQVLTYIEGAYARTKTNDKGKTEKTGKEKSVGVGLRVYF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein P2, OMP P2.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: CTRA_BRUC2
Sequence: MRVLLIEDDSAIAQSIELMLKSESFNVYTTDLGEEGIDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLSKVKTPILILSGMAGIEDKVRGLGFGADDYMTKPFHKDELIARIHAIVRRSKGHAQSVITTGDLVVNLDAKTVEVAGQRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLDAVSGNQSYIETVWGRGYVLREPDAEMRESA
What is the function of this protein?
Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes.
What are the official names of this protein?
Cell cycle response regulator CtrA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIF_BUCAP
Sequence: MNFSTIEESVSEEKKKFNNFLSYFFKNSRVLIILFVLAVITTVSISMWRKSPDYQVLYNNLSNEDGEMIIDQLNQMQIPYKLSEDSGQLLVPKDKVYELRLHFSENNSPHRDIGYEILDKERFGVSQFGEQINYQRALEGELARTIEKINVVKNAKIHIAFPKNSLFLEDKKKPSVSVILNLKSNQGLDHSQVNAILHLISSSICDLSIENITIIDQFGKLLNNSSLGLNQIDDLKLRYSEEVESRYRNRIKNILEPLLGFNNVYAQVTAQINFNSHEKTQEKYTPNTNYKNQAIRSRQSTVNDKINNRKEENKPDELFPQTSFSSNKDLNSTTYSNKKIKKSIIQNNQDNNILHSNSAISHDDTINYELNHSLSHTKMNIGEIKRLSAAVIVNFVKDKNGKSVPINVEQIKKIKNLVREAIGYSKVRGDSVYVVNESFFQKNKNSPIKLLKDSNQSNFYSTFLTFTPWFISLFFLFFLVKKCFFSSSKNNINNQSYKNKTEEDLLEKDTKAENISELKFSKTSNTDKLIHQICNISNQNPRIIASIIRQWMSDKK
What is the function of this protein?
The M ring may be actively involved in energy transduction.
What are the official names of this protein?
Flagellar M-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FliF family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: ISPD_CLOK1
Sequence: MKSNYAVIVAAGKGKRMKMPINKQFICIQGKPILYYSISVFSKNPLVDKIVLVCAEDEIEYCKQEIVKKYNFDKVVKIVSGGKERQHSVFNALKVLENCSVVLIHDGARPFVTDRIIEDGIKYSNMYGACACGVVPKDTIKIKGKEGFSYKTLVRKELFIVQTPQCFDYNLIYDCHKKLANNKVQVTDDTTVAEYFGNMVYLYEGSYDNIKITTPEDLIIAENIFKTHKYI
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: METK_ASCIM
Sequence: MSIPVNPNSFKGSFLFTSESVGEGHPDKIADQVSDAVLDACLAEDPLSKVACETATKTGMIMVFGEITTKAHLDYQKIIRNAVKDIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGYATDETPELLPLTLLLAHQLNANMAKARRDGSLPWLRPDTKTQVTIEYEHDGGAVVPKKVKTVVVSAQHSEDITTEELRKEILEKIIKTTIPAKYLDEDTVFHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVTAGLVRRCLVQLSYAIGVAEPLSIFVEDYGTSAEGRTSDQLVEIIRKNFDMRPGVIVQELDLAKPIYFQTAKNGHFTNQEFAWEKPKKLNL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: FKBP7_PONAB
Sequence: MPKTMHFLFRFIVFFYLWGLFTAQRQKKEERTEEVKIEVLHRPENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSTETFKQIDMDSDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL
What is the function of this protein?
PPIases accelerate the folding of proteins during protein synthesis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP7, PPIase FKBP7, FK506-binding protein 7, FKBP-7, Rotamase.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PLCG1_MOUSE
Sequence: MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERSTSDGPSSATNLIEDPLHDKLWKCSL
What is the function of this protein?
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).  Plays an important role in the regulation of intracellular signaling cascades.  Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).  Plays a role in actin reorganization and cell migration (By similarity).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-gamma-1, PLC-gamma-1.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Protein: RL14_AKKM8
Sequence: MIQMESLVQVADNTGARSAKMIGVIGKRTRQAHIGDIITCHIRESIPTASVKKGTVVKAVVVRTAAPIRRDDGSVLRFDGNAVVIIDKDNNPRGTRIFGPVARELREKKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYT_TREDE
Sequence: MSTLQEKSKKLGTLRHSTAHVMAEAVVNLFPGTKVAIGPAIDYGFYYDFELPRPINNDDLPAIEKEMRKILTTRSNFEKEVISREKALEMFKDQPFKIELIKGLPADEEISIYKSGEFTDLCRGPHVCSMADINAQGFKLMKIAGAYWRGDETRPMLTRIYGTAWEKPNDLKEYLAMLEEAEKRDHRRIGKAMNLFHIDEENPGQIFWHPKGWTLYLTIQNYVRKRIKEDGYLEVHTPFVMPRSLWERSGHWAKYKENMFITESEKRLFALKPMNCPGHVEIFKQGIKSYKDLPLRLAEFGSCTRNEPSGSLHGIMRIRGFVQDDAHIFCTEEQISSEVSKFCALLKRMYADFGFAEDKILVKFSTRPEQRVGDDATWDRAEKALSDACADAGLKYEIAEGEGAFYGPKLEFTLIDALGREWQCGTIQLDYQLPSAERLNAEYIGDDNNKHHPVMLHRAVLGSLERFIGILIENCAGIMPPWLAPVQAVIVPVAPAFNEYAQKVQKVLDEKGFRVIADIGTDRMNAKIRKHQEEKVIYQLIVGQSEMDNNSVAVRMRKGGQKVMTLDEFISFLKDKVDSFAIDSE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HVC33_HUMAN
Sequence: MEFGLSWVFLVALLRGVQCQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 3-30-3.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: IF1_ACIAD
Sequence: MANKEELIEFEGVVTETLPNTMFRVRLENGHEVIAHISGKMRKHYIRILTGDNVKVEMTPYDLSKGRITYRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETR1_YARLI
Sequence: MLRTLRTSQLARSGFGTPSFGLRFNSVGRAFVFSQTGEPKDVIQVLEYPIEKPLENQVLLKSLGFTINPADINQLEGVYPSVPPKSVQINNEDAAIGGNEGLFQVLDPGAKSGLKKGDWVLPRKTCFGTWRSHALVEADTVVKIDNTDLTKVQATTVSVNPSTAYEMLKDLKEGDWFIQNGGNSGVGRAAIQIGHIRGLKSISVVRDRPDLEVLKKELTDLGATHVITEEEASDKLFSKQIKSWTGGKIKLALNCIGGKSATSIMRQLGAGGSIVTYGGMSKKPLTFPTGPFIFKDITAKGYWLTRWADKHPEEKAKTIENIFKFYREKKFVAPPVNISTLDFSKGNDVVLSEFLDALGKAQKGGGKKQLVQWVEY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II).  Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.  Required for respiration and the maintenance of the mitochondrial compartment.
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase, mitochondrial, 2-enoyl thioester reductase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.