PharMolix/UniProtQA huggingface dataset:
Protein: HEMA_HUTV
Sequence: MLSLILFFPSFAFAVTPVTPYFGPLYITFNCCLFGDSRSDCTKVQSPMSLDNPQNFCPNFSLKSSSSMFFSIHYNNHSSLVLFDNFNCRIEKVYYNGVNLSPRNQYSCYDEGVDSYMELKTSFNIKLNQMATILRCIKLIQLKARSSFTTLQDVVCRTNKYLPNNPTFALLSDTVPTWVQFVLPDLSGKTICIKYLVPFCHLNHGCFTAGSSCPPFGVSYVSDSFNYGFNDATPYIGLAESHDNVCDYLFVEAGTHNASIVGNFLFYPTKSYCFNTMNFTVPVQAIQSIWSEGNESDDAIAEACKPPFCIYYSKTTPYTVTNGSNADHRDDEVRMMVRGLLYNSSCISAQGSTPLALYSTAMLYAPIYGSCPQYVKLFDTSGSESVDVISSSYFVATWVLLVVVVILIFVIISFFC
What is the function of this protein?
Structural protein that makes short spikes at the surface of the virus.  Contains receptor binding and receptor-destroying activities.  Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells.  This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.  May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one.  Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.  However, its presence in the virus may alter its pathogenicity.  May become a target for both the humoral and the cellular branches of the immune system (By similarity).
What are the official names of this protein?
Hemagglutinin-esterase, HE protein, E3 glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface (By similarity).
Protein: RS14Z_MYCBO
Sequence: MAKKALVNKAAGKPRFAVRAYTRCSKCGRPRAVYRKFGLCRICLREMAHAGELPGVQKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: PRMA_CLOBB
Sequence: MNGVWIEVRVITSCEAIEPISGIFYGLNSQGVAVEDPNDLLTRDQGPLTWDFADINVLEHKGEFAVVKAYFSGDDDLEKIVSITKEKVKEIQEMGIDIGKGIVECDKIKEEDWANNWKKYYKPSNITDRIVVKPMWEEYSPKNEELVIELDPGMAFGTGTHETTRMCVKALEKYVEHDSTVFDVGCGSGILAIAAAKLGAKLALGVDLDPVAVESAKENVGLNDLDNIEILEGNLLDVIDGKADIVVANIIAEIICILTDDVSKALNKGGLFITSGIIHERVDMVTSKLDECGFEVMEVNKDGEWNCIVAKLK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLD10_BOVIN
Sequence: MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKTCVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALIGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCLIGGVIFCFSISDNNKAPRMGYTYNGATSVMSSRTKYHGREGDLKTPNPSKQFDKNAYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.  Involved in the regulation of paracellular epithelia permeability to ions in multiple organs.  It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions.  In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function.
What are the official names of this protein?
Claudin-10.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: YIDD_GEOSL
Sequence: MLKGILYIIGIYQRYLSPLKGPTCRFYPSCSRYAHESLTRYGLVKGLWLTTIRILKCHPFHPGGVDPVK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: O2VC1_CONVC
Sequence: MGKLTILFLVAAALLSTQVMVQGDGAHERTEAEEPQHHGAKRQDGTGGYPVDDVDMMQRIFRTPLKRQWCQPGYAYNPVLGICTITLSRIEHPGNYDYRRGRQ
What is the function of this protein?
Unknown.  Intracranial injection of the peptide into mice does not produce toxic effects (PubMed:26774129).  In addition, the pepide does not produce any observable changes to normal or depolarization-induced intracellular calcium levels in mouse dorsal root ganglion cells (PubMed:26774129).
What are the official names of this protein?
O2 contryphan Vc1, O2_Vc1, Contryphan Vc1, Con-Vc1.
What is the protein family that this protein belongs to?
Belongs to the O2 superfamily.
Protein: PLSY_STAA8
Sequence: MMIIVMLLLSYLIGAFPSGFVIGKLFFKKDIRQFGSGNTGATNSFRVLGRPAGFLVTFLDIFKGFITVFFPLWLQVHADGPISTFFTNGLIVGLFAILGHVYPVYLKFQGGKAVATSAGVVLGVNPILLLILAIIFFIVLKIFKYVSLASIVAAICCVIGSLIIQDYILLVVSFLVSIILIIRHRSNIARIFRGEEPKIKWM
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMPA_STRAW
Sequence: MTALTLSTAAASGLRADAIVVGVAKSPKGDKGLVVAPGAEAVDKGYDGKLAAVLETLGASGAEGEVTKLPAPSGFKAPVVVAVGLGAAPEDGQDKGTAFDAEALRRAAGAAARALAGAKKAAFALPVADAADAGTIGEGALLGAYSFDAYKENGRNAKNGKAPLAEVVLLGGKPRDKAFKAAVERAVAVTEELNRARDLINTPPNDLNPESFAAVAQAAAKEHGIKVQVLDEKALTKGGYGGILGVGAGSAAGPRLVKLSYTSSKAKKHLAFVGKGITYDSGGISLKPAGHNETMKCDMSGAAAVFAAVVAAARLGLEVNVTGWLALAENMPSGTATRPGDVLRMYSGKTVEVLNTDAEGRLVLADALWAASEEKPDAIVDVATLTGAMMLALGNRLFGVMANDDAFRTAVVEAAEEVGEDSWPMPLPEHLRKGMDSPTADIANMGERMGGGLVAGLFLREFVGEGITWAHLDIAGPAFNEAAPFGYTPKGGTGTAVRTLVRLAELTAAGDLG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_HYDCU
Sequence: MWTYPEIDPVALTFGPLQIHWYGLMYLAGFAFFWGYGSYKAKFSDHWTAERVGDFLFYGALGVILGGRIGYILFYDLAHYIAEPLDVFQVWKGGMAFHGGLIGVMVAMWLFARKMQVSMFVVADFVAPMVPVGLFFGRIGNFINGELWGKVTDSSLGMKVYDPTLNMVVSKYPTQLLEALLEGIVLFIILMFYTRSPRPLGAASGLFIGLYGLFRFYVEFFRLPDPQLGYLFWGWVTMGQLLSLPMILIGFALVVWAYRNNRVMAP
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPH_CERSP
Sequence: MPGVVFDLDGTLVHSAPDIHAAVNKALAEEGGAPFTLAEITGFIGNGVPVLIQRVLAARGEAPDAHRQAELQGRFMAHYEADPATLTSVYPGAEAAIRHLRAEGWRIGLCTNKPVGASRQILSLFGLLELFDAIIGGESLPQRKPDPAPLRATAAALNEEVVLYVGDSEVDAATAEAAGLRFALFTEGYRHAPVHELPHHGLFSHHDELQDLLRRLLA
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: PGK_LACPL
Sequence: MAKLIVSDLDVKDKKVLIRVDFNVPIKDGKIGDDNRIVAALPTIKYVIEHDGKAILFSHLGRIKSEDDKKGLSLRPVAERLSNLLNKPVTFVPVTEGEQLETAINNMNDGDVLVVENTRFEDVVNGEQVKRESGNDPELGKYWASLGDVYVNDAFGTAHRSHASNVGIASNMDQVAAGFLMEKEIKFLGDAVDNPKHPFVAILGGAKVSDKIGVIDHLISKADKIIIGGGMTYTFYAAKGMGIGNSLVEKDKIELAKSIIEKAGDKLVLPSDSIVAEKFDNDVPSKVVEGSIPDGYMALDIGPKSIEEFEDVLRDAKTVVWNGPMGVFEMSNYAKGTLEIGKFLGTLSDATTIVGGGDSTAAVKQLGVGDKLTHISTGGGASLEYLEGKELPGIAAISEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_FLAJ1
Sequence: MIKITLPDGSIREFAQGVTPMEVAKNISEGFARNVISASFNGTTIETETPLTTDGNLILYTWNDAEGKKAFWHSTSHVMAQALEELYPGIKLTLGPAIANGFYYDVDFEDQKISEADFKKIEDRILEIARGKFDFKMRPVTKAEALEMYKDNVYKTELISNLEDGTITFCDHATFTDLCRGGHIPNTGIIKAVKIMSVAGAYWRGDEKNKQLTRVYGTSFPKQKDLTEYLELLEEAKRRDHRKLGKELELFAFSQKVGQGLPLWLPKGAALRDRLEQFLKRAQKKAGYEQVVSPHIGQKELYVTSGHYAKYGADSFQPIHTPAEGEEFLLKPMNCPHHCEIYNVRPWSYKDLPKRYAEFGTVYRYEQSGELHGLTRVRGFTQDDAHIFCTPEQLDEEFKKVIDLVLYVFGSLGFENFTAQISLRDQEDREKYIGTDENWEKAENAIINAAKDKGLNTVVEYGEAAFYGPKLDFMVKDALGRQWQLGTIQVDYNLPERFELTYKGADNELHRPVMIHRAPFGSMERFIAILLEHTAGNFPLWLMPEQAIILSLSEKYENYAKKVLDLLENHEIRALIDNRNETIGKKIRDAEMQKIPFMLIVGEEEEKNGTISIRRHGQEGKGNITVSIEEFASIVDEEIKKTLKVFTV
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAA_SHIB3
Sequence: MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLLKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: TIP22_ORYSJ
Sequence: MSGNIAFGRFDDSFSAASLKAYVAEFISTLVFVFAGVGSAIAYTKLTGGAPLDPAGLVAVAVCHGFGLFVAVAIGANISGGHVNPAVTFGLALGGQITILTGVFYWIAQLLGAIVGAVLVQFCTGVATPTHGLSGVGAFEGVVMEIIVTFGLVYTVYATAADPKKGSLGTIAPIAIGFIVGANILVAGPFSGGSMNPARSFGPAVASGDYTNIWIYWVGPLVGGGLAGLVYRYVYMCGDHAPVASSEF
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.  May be involved in transport from the vacuolar compartment to the cytoplasm (By similarity).
What are the official names of this protein?
Probable aquaporin TIP2-2, Tonoplast intrinsic protein 2-2, OsTIP2;2.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: YVDD_BACSU
Sequence: MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVGLMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFISMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHLKLIHSSSRPDELIEQMQNYSYPILEKKWTEI
What are the official names of this protein?
LOG family protein YvdD.
What is the protein family that this protein belongs to?
Belongs to the LOG family.
Protein: BTUD_ECOSM
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VGA6_ALHV1
Sequence: MHKHSATADMLPISAFSPLKFLGGVVATPQGPVLWDATTTPVPFQAFPCPPAITPINQFVNYQPAPAMDKIWRPAFEDYRGVTMRPALPEVPETSLRPALQELPEPSSPQSQSSVDDDTDSKEDVTETLECAQALTDLKWGTVDPPRSTSPVTASTSSGVSSDLQKAKEQAIRRYRLIEAKDLGKLVVRGPKKDKRDPDFYIKKVPLHFS
What are the official names of this protein?
Uncharacterized gene A6 protein.
Protein: EP450_ASPRC
Sequence: MWDSPIIFTTMRELVQSVSPAALSWAVVAIYLGTFFWLRSRSSKQRLPLPPGPRGLPLIGNSLQTPAVNPWEKYKEWSDEYGPVMTLSLGLTTTIILSSHQVANDLMEKKSTIYSSRPQLVMFNRLSGGMNSSGMEYGKRWRDHRSLQASVLRPWMTQRYTALRDVETKQLLAELLNTDDFSSCFKRMVASLFMTLAYGKRVQYPDDPEIRGMEELVRVKSEAGEASFRATGQLVEYIPLLQYLPSFLTPWKEMCDRICEQFNKTFVDRLRDGINAPAWTWAKEVSKHKVARPMSELEISYTLGTLYEASLTSQQILRIIVLVAALYPEKTAKAQEELDRVVGTGRLPAAADARNLPYIDAFVKEALRWRPFAPLGAPRESIRDVEYNGYLIPKGATILVNQWALDYNEDMFPEPFSFLPERWVANPNLPFSTFGFGQRGCPGRYFAQDSLFISTARLLWAFNIRTASPVEVEDMLRNPSAGAFLSPIPEFDATFTARDAQRKALIEKEWEISPKESYAILQEVEKELISEGAE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:29072465, PubMed:33381959).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS echPS via condensation of L-alanine and L-tryptophan (By similarity).  The prenyltransferase echPT1 then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (PubMed:33381959).  Preechinulin is the substrate of the cytochrome P450 monooxygenase echP450 that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (PubMed:33381959).  The unique prenyltransferase echPT2 functions as a competitive enzyme with echP450 for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by echPT2 at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by echPT2.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by echPT2, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  EchPT2 accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  EchPT2 further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to echPT2 for C5 and C7 prenylation (PubMed:33381959).
What are the official names of this protein?
Echilunin cytochrome P450 monooxygenase, EchP450, Echinulin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: CYSK4_ARATH
Sequence: MAFASPSLRLLPQSPLGRITSKLHRFSTAKLSLFSFHHDSSSSLAVRTPVSSFVVGAISGKSSTGTKSKSKTKRKPPPPPPVTTVAEEQHIAESETVNIAEDVTQLIGSTPMVYLNRVTDGCLADIAAKLESMEPCRSVKDRIGLSMINEAENSGAITPRKTVLVEPTTGNTGLGIAFVAAAKGYKLIVTMPASINIERRMLLRALGAEIVLTNPEKGLKGAVDKAKEIVLKTKNAYMFQQFDNTANTKIHFETTGPEIWEDTMGNVDIFVAGIGTGGTVTGTGGFLKMMNKDIKVVGVEPSERSVISGDNPGYLPGILDVKLLDEVFKVSNGEAIEMARRLALEEGLLVGISSGAAAVAAVSLAKRAENAGKLITVLFPSHGERYITTALFSSINREVQEMRY
What is the function of this protein?
S-sulfocysteine synthase that plays an important role in chloroplast function and is essential for light-dependent redox regulation and photosynthetic performance within the chloroplast (PubMed:20179139, PubMed:22829322, PubMed:23333972).  Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) required for O-acetylserine (thiol)-lyase (OAS-TL) enzymatic activity (PubMed:18223034).  Lacks OAS-TL activity (PubMed:20179139).
What are the official names of this protein?
S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic, AtCS26, Beta-substituted Ala synthase 5;1, ARAth-Bsas5;1, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: CLC4G_HUMAN
Sequence: MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILLSKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC
What is the function of this protein?
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).
What are the official names of this protein?
C-type lectin domain family 4 member G, Liver and lymph node sinusoidal endothelial cell C-type lectin, LSECtin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: GSIC_SALCH
Sequence: MLNYVLKRLLGLIPTLLIVAVLVFLFVHLLPGDPARLIAGPEADAQVIALVRQQLGLDQPLHVQFWHYITHVLQGDFGTSMVSRRPVSEEIASRFLPTLWLTITSMIWAVLFGMAIGIAAAVWRNRWPDRVGMTLAVTGISFPAFALGMLLMQIFSVDLGWLPTVGADSWQHYILPSLTLGAAVASVMARFTRSSFVDVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVDMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPAIRYK
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutathione transport system permease protein GsiC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FABA_SHIBS
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCL1_YEAST
Sequence: MSSSAPKYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKGIGFTNTSKKIA
What is the function of this protein?
Does not have cyclase activity.  Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.  Essential for viability.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EST1_MESAU
Sequence: MPLNRFPCWRYAVACGLLLLLVHVHGQDSVSPIRNTHTGQVRGKLVYVKEGVTGVYAFLGIPFAKPPVGPLRFAPPEPPEPWSGVRDGTSEPAMCLQTDFMRPQISKERKIILPTISMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVMGMASMNDGSLLAATEDIVIVSIQYRLGILGFFSTGDEHARGNWGYLDQVAALHWVQQNIASFGGNPGQVTIFGVSAGGTSVSSLVVSPMSKGLFHGAIMQSGVALLPDLISDTPEAVYTPVVANQSGCEAKDSEALVHCLREKTEAEILAINQVFIMTPGVVDGIFLPRHPQELLASVDFHPVPSIIGVDSDECGWGVPLFMGLDHVIKNITRETLPAFLKSRAEHMMLPPECSDLLMQEYMGDVEDPQTLQAQFRELMKDFMFVIPALKVAYFQRSHAPVYFYEFQHQSSFIKNKDARPSHVRADHGDHVAFVFGSDFWGLKIDLTEEEKLLNKRMMKYWANFARHGNPNSEGLPYWPELVHDDQYLKLDIQPAVGRALKSRKLHFWTKILPQKIQELKGAQGKHSEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
What are the official names of this protein?
Liver carboxylesterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum.
Protein: FDHD_ECO7I
Sequence: MKKTQQKEIENVTNITGVRQIELWRRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNGLEVQIELSSRRFMGLKERRRALAGRTGCGVCGVEQLNDIGKPVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEGESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLSN
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_CAUVN
Sequence: MAEAPHTLKFERLRKRPDFLLAAKAPALSRGAVFIQMRQRTDDDPTVRVGFTATKKIGGAVERNRAKRRLREAARLVLPLHARPSHDYVFIARGGTGTREWARLLDDVKTALISLAADLDRGGTKVSRRSNGALHDAAPSSQPDPTVSG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.