PharMolix/UniProtQA huggingface dataset:
Protein: ORN_HALHL
Sequence: MGFSEWNLIWIDLEMTGLDPSRDRIIEIAVVVTDSNLDTLAEGPVLAIHQDRSLLDSMDEWNTRQHGRSGLTERVRASTVTEAEAEAQVLAFLKQYVPARTSPMCGNSICQDRRFLARWMPDLEAYFHYRHIDVSTLKELARRWSPEVAEGVRKSGNHLALDDIRDSIHELRHYRREFLRMPA
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDLR1_XENLA
Sequence: MMKPAASFPLLLLGLCHVSAISGIRKCDRNEFQCGDGKCIPYKWICDGSAECKDSSDESPETCREVTCGTDQFSCGGRLNRCIPMSWKCDGQTDCENGSDENDCTHKVCADDQFTCRSGKCISLDFVCDEDLDCDDGSDESYCPAPTCNPAMFQCKDKGICIPKLWACDGDPDCEDGSDEEHCEGREPIKTDKPCSPLEFHCGSGECIHMSWKCDGGFDCKDKSDEKDCVKPTCRPDQFQCNTGTCIHGSRQCDREYDCKDLSDEEGCVNVTKCEGPDVFKCRSGECITMDKVCNKKRDCRDWSDEPLKECGENECLRNNGGCSHICNDLKIGYECLCNEGYRLVDQKRCEDINECENPNTCSQICINLVGGYKCECREGYQMDPVTASCKSIGTVAYLFFTNRHEVRKMTLDRSEYTSVIPRLKNVVALDMEIASNKIYWSDLTQRKIYSASMEKADNTSHHETVISNQIQAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRRTPPSDDLEKPRDIVVDPSQGFMYWTDWGLPAKIEKGGLNGVDRYPLVTENIEWPNGITLDLINQRLYWVDSKLHSLSCIDVTGENRRTVISDETHLAHPFGLTIFEDLVFWTDIENEAIFSANRLTGRNIMKVAEDLLSPEDIVLYHNLRQPKAENWCEAHHLGNGGCEYLCLPAPHITARSPKFTCACPDGMHLGDDMRSCVKEPVIPEASPTTTTSAPVTTTTSAPVTTTTSAPVTTTSTTARPTSRSTTLAKITSTTSTLAPQRPKMASTTIAPQRPTTNSPKTTLRMITEKVPDHTTQQPMTHSQLADNNFAKAGVVENVRSHPTALYIVLPIVILCLVAFGGFLVWKNWRLKNTNSINFDNPVYQKTTEEDQVHICRSQDGYTYPSRQMVSLEDDIA
What is the function of this protein?
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.  In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
What are the official names of this protein?
Low-density lipoprotein receptor 1, LDL receptor 1.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome. Note=Rapidly endocytosed upon ligand binding.
Protein: CRM_DROME
Sequence: MEELSKQPPPPPLTQPPPPSSSVSIEEPLPNGKGGGAVVVNSIAKLPEEELLGSVTMHNCPGTRASARVIQKMKQDQTRPMTPPPSEREPNKKEEKAAQKTPSQLKTGSGKTTWTNVERNCFFDALNEFGKDFEAVANCINAKLKRRNANSDYSFKTKDQVRQHYYQTHHKICKYVRFSEELKKPAQELYTLINYGEMRRKLQFLTEKHFMKLKQLVYQGQITVRCKGKNIRIKTPSCKALRRLNQLDDSLEDIRLPSKVEVLVTPANMEAFGRVQSLAQNPRGRIIVPLHKKLISFIKTFEYKWRSANQRLHEEKSAYFSSSLPSAASNNNNNNNETEPLQPSVASLDPSMCFQPRPGVAIHRPLLSITAYLSSISICLTAYEERMGFKVRSETLGNLAGMSVAANKRLRTESGSEKRSPETKKPKSSASPPLEKSLDDGPLEGNLMKMENSSGDELGEEIHEFLGDILEAMQHPQAATIPALSATTGDTTNVAVALETSHDPVQQAYPANADLSNAMATSVLQTSCAAAPAPSTPVTGSLAAPSVARSKRKEAKEAAAAAQARNFKPLLSDDILKRIRKGWTQANAADITIGDLYVVFGQDSKLELEYYWCEVDSSTAMASSILTINTVTPSSSSVGTQTGSAASNANQTGASSNCYVSASSNSSTSSTSLPYNPNDCDSVERVRAVTTSSVSNKLKHLLLVANLSERVRKRQCNCGHTCDRKRDLMTKAQQLAEATATGGVGGMVEGNFRTPMLPVRRPISNIDPVRQLSALTRQKISRQVLVQRRLLPPTSAGDRPYDLLSVRQLHSGLFEPIDRVDGTSSAGISTSGSKPDCSMNAMTASQDQEPGDQGALEFLNDEATQVSARDMPNLDICVATNRTDVSSSLNEAAQDGSTTQSFFQGSMSPMHLLRDSTSNARWLEDNINDFSLTSLLGHLDEIDATRDILDPSSSMSVISESSVDFRHKFQEIAALLQQQEKD
What is the function of this protein?
Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination.  Can act as a modifier of position effect variegation (PEV).
What are the official names of this protein?
Protein cramped.
What is the protein family that this protein belongs to?
Belongs to the cramped family.
What are the subcellular locations of this protein?
Nucleus. Note=During S-phase in early embryogenesis. Colocalizes with PCNA in polytene nuclei during embryogenesis.
Protein: ZN727_HUMAN
Sequence: MRVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEPWNARRQKTVAKHPAGSLHFTAEILLEHDINDSFQKVILRKSGSCDLNTLRLKKDYQRVGNCKGQKSSYNGIHQCLSATRSKTCQYNKCGKAFGLCSIFTEHKKIFSREKCYKCEECGKDCRLSDFTIQKRIHTADRSYKCEECGKACKKFSNLTEHNRVHTGKKPYKCEECGKTFTCSSALTKHKRNHTGDRPYKCEECHKAFRCCSDLTKHKRIHTGEKPYKCKECHKAFRCCSDLTKHKRIHTGEKPYKCNECGKAFMWISALSQHNRIHTGEKPYICEECGKAFTYSSTLISHKRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTGEKPYKCEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLIKHKRSHTGDRPTSAKNVAKPLGGSQTLLNIR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Putative zinc finger protein 727, Zinc finger protein 727 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TAL_RHILW
Sequence: MTSKLDQLREITTVVADTGDIEAVARLKPVDCTTNPSIVLKALGTPMFADAIKEAVAWGKKQGGNPDAVSSAVADRLAISVGAALVKLVPGRVSTEVDADLSFDTEASLAKARSIIAAYKDRGIDQDRILIKLASTWEGIRAAEVLQKEGIDCNLTLLFSKAQAIACADAKVFLISPFVGRILDWYKKSTGKDYTAEEDPGVISVREIYNYYKANDIKTIVMGASFRSAGEIEALAGCDRLTISPNLLDELAKDEGKLERKLSPEGRKPDPKVSVDEKTFRWMMNEDAMATEKLAEGIRAFAKDLGTLRTMVQKELQLAAA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U512V_DICDI
Sequence: MTLFNSISSISNSTGLSKQSLIVNVDGNTSSSGGNSTSWLGGFDGCGGCGGFGSYGGCRGFGGCGGSNLNIINVDIDIGRRRRRCC
What are the official names of this protein?
UPF0512 protein V.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: CH60_MALP2
Sequence: MAKEIKFSDSARNKLFNGVQQLFDAVKVTMGPRGRNVLIQKSYGAPVITKDGVSVAKEVDLTNPIENMGAQLVKDVASKTADEAGDGTTTATVLAYGVFKEGLRNVISGANPIEIKRGMDKTVNAIVNELNKSSKKIARKDEIIQVATISANSDKKIGELIANAMEKVGSDGVITVEEAKGINDELTVVEGMQFDRGYISPYFVTDTNKMIAKLENPYILITDKKVSSIKDILPILEEIMKTGRPLLIIADDVDGEALTTLVVNKMRGVFNVVAVKAPEFGDKRKQVLEDIAILTGGSFVTDDLGISFDKVTLQDLGQAESVVIDKDNSTIVKGKGLESQIKERISKIKTAIEMTDSDYDKDSLRNRLAKLNKGVAVIKVGAVSEVELKEKKDRVDDALSATKAAIEEGIVIGGGAALVHVSKRINVNTLNLIGDEKIGYQIVMSAIMSPISQIVSNAGFDKGVVINEILKATNPHLGFNAATGKYVDMFQTGIIDPVKVTRIALQNAVSVSSMLLTTEAVIYDVKDDKEDSVPAMPNMGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNN1_RAT
Sequence: MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGSNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELDEPTHNHHPHNYYNSA
What is the function of this protein?
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.  It is capable of binding to actin, calmodulin and tropomyosin.  The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
What are the official names of this protein?
Calponin-1, Basic calponin, Calponin H1, smooth muscle.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: IHFB_DICD3
Sequence: MTKSELIERLAGQQSHIPAKVVEDAVKEMLEQMATTLASGDRIEIRGFGSFSLHYRAPRVGRNPKTGEKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: AGR2_PONAB
Sequence: MEKISVSAFLLLVALSYTLARDTTVKPAAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPTDTALLLDNMKKALKLLKTEL
What is the function of this protein?
Required for MUC2 post-transcriptional synthesis and secretion.  May play a role in the production of mucus by intestinal cells.  Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity).  Promotes cell adhesion (By similarity).
What are the official names of this protein?
Anterior gradient protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the AGR family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum.
Protein: RS18_SALSV
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RUVB_PHOLL
Sequence: MIEADRLVSAEVLQDDEAIDRAIRPKLLSEYVGQPQVCEQMEIFIQAARQRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYNVDDLQSIVSRSARFMGVEITDDGARQVAMRSRGTPRITNRLLRRVRDFAQVKGNGAIDGNIATRALDMLSVDAAGFDYLDRKLLIAIIDKFMGGPVGVDNLAAAIGEERETIEDVLEPFLIQQGFIQRTSRGRIATEHAYRHFGMVRNQE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: GNAF_DROME
Sequence: MKLRLLRCLRQQPAKPAAVMTHKEDQYPVSLDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPEYMNEEYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQITFRVPIPKSMGGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein G(f) subunit alpha, G protein alpha f subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: PNP_SHEB2
Sequence: MNPIVKSFEYGQHTVTLETGVIARQADAAVLASMGDTTVLVTVVGKKEADAGRDFFPLTVNYQEKTYAAGKIPGGFFKREGRPSEDETLIARLIDRPIRPLFPNGFKNEVQVIITVVSVDPQIEPDIISMIGTSAALAISGIPFSGPLGAARVGYIDGEYVLNPSVAQLATSQLNLVVAGTAGAVLMVESEAQALPEEVMLGSVVYGHDQQQVVIKAIAEFKAEAGKPTWDWTAPTQDADLVAQIKELAEAGLGDAYKIQVKQDRYAQVSVVKAATKEALLASNPSIDLREVDNLLGSLEKKVVRGRIIRGEPRIDGREPDMIRALSVLAGVLPRTHGSALFTRGETQALVTCTLGTERDAQKIDSIMGERTNRFMLHYNFPPYSVGETGMVGSPKRREIGHGKLAWRGINAVMPSAAEFPYSVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKTSVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTRDGITALQMDIKIEGITKEIMDIALQQAYGARVHILNVMDQAIGSHRDDISDHAPRITVIKINPEKIRDVIGKGGAVIRALTEETGTTIELEDDGTVKIASSNGEATKEAIRRIEEITSEVEVGRIYNGKVIRIVDFGAFVNILPGKDGLVHISQISDERVANVSDHLELNQEVAVKVMEVDRQGRVRLSIKEAQTKETAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAIB_PROM9
Sequence: MAARKTYILKLYVAGNTPNSMRALNTLREILENEFKGVYALKVIDVLKQPQLAEEDKILATPTLAKILPPPVRRIIGDLSDREKVLIGLDLLFDELTETEYSGDK
What is the function of this protein?
May be a metamorphic protein which reversibly switches between an inactive tetrameric fold and a rare, thioredoxin-like monomeric fold (KaiB(fs)).  KaiB(fs) binds phospho-KaiC, and perhaps clock output effectors.
What are the official names of this protein?
Circadian clock oscillator protein KaiB.
What is the protein family that this protein belongs to?
Belongs to the KaiB family.
Protein: FKH5_CAEEL
Sequence: MQYALTVIFQSILFVQCQVGEAAFVISQEHEVSKSISINMTLFPSIKWIIHKSFYLYLTYFVMSQQTLPCFQAADSYNYSHSLPKVQFARFSKYTPQSISYSSTQMYQQKEYSDHITEMTNVHKSRKRKLMVTEDQWGSQITIPKVIQNRPLIEKWFVQKRFKMVKVRNIQRPQLSYQLLSALTCLNSPDGMISTTEIYSFILHHWRYYRYANENWKNSVRHVLCKCQLFDVLQVEGLSRKGNVYKLKRPDNVEKEMIDVKTLGCMQKDSRGIDFYIKMLAGQIGLPRHLFYSIVGNEMPEYAGPENSAIFYHLLSMRKIIPKLETRYFLEHWQMEHKATEPMFFEEFVPYSTSLVSCVENISSYGEGVGPGNDELYDLSDRQIICFHKNIRAYHSLQKRCHKMNYSNWMTPSLIYVQEAVMDKEIVEDDIRNGTIECEGVARKEEAKKNFQDPALISIYN
What is the function of this protein?
Transcription factor (By similarity).  Binds to DNA sequence motif 5'-CTGTTTCA-3' (PubMed:22819322).  Regulates expression of a class of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4 and fkh-3 (PubMed:22819322).
What are the official names of this protein?
Putative forkhead-related transcription factor fkh-5.
What are the subcellular locations of this protein?
Nucleus.
Protein: EX7L_ANAMM
Sequence: MSLRSCSTEMIPEFTVTEITDLVRQVMHDTFYCIKIRGEISGLSRPSSGHVYLSLKDDNSVISAVCWNGTRLDVQFENGLEVICTGHLSTYQSRYQLVIEGMVLAGQGKLAAMLEERRKKLEKEGLFDQARKKPLPLLPLKIGVITSPTGAVIRDILNRVKHRFPSHIIVWPVQVQGSQASAMVVQAILGFNNLEEPPDVIIVARGGGSIEDLWPFNDEELARTTAASKIPIVSAIGHETDFTIIDYAADVRAPTPTAAVEIVLPERQQLVSDIAHKLSKIRSAVRNVLGAKEHRLLQLYGVLTETKHKISEVGRSALAHQEKIEFLFKVALLKKQQYLDNLIGRIDRYNKEHIISVGYAVIYDNTGQHVSSANAVAPDDTIVIEWKDGKRRAAILT
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_PSEMY
Sequence: MTGLFITLEGPEGAGKSTNREYLAERLREQGVDVVLTREPGGTPLAERIRELLLDPSDEPMAADTELLLVFAARAQHLQQVIRPALAKGCVVLCDRFTDATYAYQGGGRGLSIERIAQLEQFVQGELRPDLTLIFDLPVEVGLARAAARGRLDRFEQEGRGFFEAVRQAYLQRAVQAPQHYRVLDAGQTLAQVQADIDALLPSLLEACRG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: Y143_CUPPJ
Sequence: MSARRPPRATPTPCPCGLGAEYDACCGRYHRGDAVPPNAEALMRSRYTAYVMGNMDWVRQTWHPSTCPADLLPDTATRWLGLSVKAHSQQDDTHAEVEFVARYKVGGRAWRLHERSRFVREPRAAGEPPVWLYVDGDMIGEAS
What are the official names of this protein?
UPF0225 protein Reut_A0143.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: DNAJ_AERHH
Sequence: MSKRDFYEVLGVSKDADEREIKKAYKRLAMKYHPDRNQGDAGAEEKFKEVKEAYEILTDANLRARYDQYGHAGVDQSQGGGGHGGFGGGADFGDIFGDVFGDIFGGSRGGGRRGPARGSDLRYTMELTLEEAVRGVSKEIKVPTLVHCEVCNGSGAHTGSSAQTCPTCHGSGQVQMRQGFFAVQQACPHCHGRGKIIKDPCRKCHGEGRYQKTKTLSVKIPAGVDTGDRIRLSGEGEAGEAGAPAGDLYVQVHVKEHEIFVRDGNNLYCEVPISFTAAALGGEIEVPTLDGRVKLKVTPETQTGKMFRMRGKGVKSVRSGQVGDLMCKVVVETPVKLTESQKELLRQLDESFSGAAAKTHKPKSEGFFEGVKRFFDDLTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_BACTN
Sequence: MAKEVAGLIKLQIKGGAANPSPPVGPALGSKGINIMEFCKQFNARTQDKAGKILPVIITYYADKSFDFVIKTPPVAIQLLEVAKVKSGSAEPNRKKVAELTWEQIRTIAQDKMVDLNCFTVDAAMRMVAGTARSMGIAVKGEFPVNN
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PHOCN_CHICK
Sequence: MVMAEGTAVLRRNRPGTKAQDFYNWPDESFEEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGGE
What is the function of this protein?
May play a role in membrane trafficking, specifically in membrane budding reactions.
What are the official names of this protein?
MOB-like protein phocein, Mob1 homolog 3, Mob3, Mps one binder kinase activator-like 3, Preimplantation protein 3.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Protein: Y034_BRUC2
Sequence: MRDMMGMMKQAKELQAKMKAMQDEIATMEASASSGGGLVTVTLSGKGTLSALKIDPSLMKEDEVEILEDLIIAAHNDAKAKLEAAMAEKTQSLTAGLPIPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BCAN_A0034.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YCIB_LEGPH
Sequence: MKLLFDFFPIVLFFIVYKFFGIYTATAVAMVASLTQVAFYRLKFQHYEKMHLFSLAIIMVLGGATLFFQNPWFIKWKPTGIYWLSALVFYGSSYIGSKPLIQKMMEANINLTTKIWYRLNLAWTLFFIVMGALNLYVAYHYDTDVWVNFKLFGGVGFTLLFVLIQAFYLTKHTDEKSFEKQ
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CADA_ALKPO
Sequence: MSDQKAITSEQEMKAYRVQGFTCANCAGKFEKNVKQLSGVEDAKVNFGASKIAVYGNATIEELEKAGAFENLKVTPEKSARQASQEVKEDTKEDKVPFYKKHSTLLYASLLIAFGYLSSYVNGEENIVTTLLFLASMFIGGLSLFKVGLQNLLRFEFDMKTLMTVAVIGGAIIGEWAEVAIVVILFAISEALERFSMDRARQSIRSLMDIAPKEALVKRNGQEIMIHVDDIAVGDIMIVKPGQKIAMDGVVVSGYSAVNQAAITGESVPVEKTVDNEVFAGTLNEEGLLEVEITKLVEDTTISKIIHLVEEAQGERAPSQAFVDKFAKYYTPIIMIIAALVAIVPPLFFDGSWETWIYQGLAVLVVGCPCALVISTPISIVSAIGNAAKKGVLVKGGVYLEEMGALKAIAFDKTGTLTKGVPAVTDYNVLNKQINEKELLSIITALEYRSQHPLASAIMKKAEEENITYSDVQVEDFSSITGKGIKGIVNGTTYYIGSPKLFKELLTNDFDKDLEQNVTTLQNQGKTAMIIGTEKEILAVIAVADEVRESSKEILQKLHQLGIKKTIMLTGDNKGTANAIGGQVGVSDIEAELMPQDKLDFIKQLRSEYGNVAMVGDGVNDAPALAASTVGIAMGGAGTDTALETADVALMGDDLRKLPFTVKLSRKTLNIIKANITFAIAIKFIALLLVIPGWLTLWIAILSDMGATLLVALNGLRLMRVKE
What is the function of this protein?
Couples the hydrolysis of ATP with the export of cadmium.
What are the official names of this protein?
Probable cadmium-transporting ATPase, Cadmium-efflux ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KEL2_YEAST
Sequence: MVPFKLTNKVPTDTGPSLISAQSVPRPIVFMDNRNNTRIVTPTLPPNQHRGISGASTALPWSPESKNTGKYIWNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGLHDQSVYGDVWQIAANADGTSFTSKRIDIDQNTPPPRVGHASTICGNAYVVFGGDTHKLNKNGLLDDDLYLFNINSYKWTIPQPIGRRPLGRYGHKISIIASNPMQTKLYLFGGQVDETYFNDLVVFDLSSFRRPNSHWEFLEPVGDLPPPLTNHTMVAYDNKLWVFGGETPKTISNDTYRYDPAQSEWSKVKTTGEKPPPIQEHASVVYKHLMCVLGGKDTHNAYSNDVYFLNLLSLKWYKLPRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQTSETDQGEGTLLYTLDLSSLNELCPGIMCESLHAGESFSNSLSGGFTPSKSTESENQEIINILTPRLPDSKVLSYNDIDEGAGSYSSALDDKAFERKSDREEKKPQSSKVDSSINKESPGTGIKVSKKNFPVLRGLTVDSEEYGSSSYKDTSCQKGIPKNLFDDLNLNLQTLRLEAQQKELETARHISQLEKEVQRLMVIKEASKDSNFQTARLKNLEIQKTFLESRINDLKNLLMVKLSQASKLCDQITIQNNGLKTCSEHVTIKRDIIDLENKCDVLKRQNEILVNNMQKITPELHTYLNESSCYLGKLLKSYPTSARPPSSEKDNQIYEKDSLNKIEKVINEMHETVRAKEKLHLETQKLNDERDSLRANLLDNNNKLDALRKLSDGSSKSMDLTKKAIHLSQSELEKYRKNNDDLQKEIDRIKTEQAEQDDKQEQRGAITHGNFDAFHRMKINNLKAELYMSKENRDSLKDELLALKKKLYTLEQKK
What are the official names of this protein?
Kelch repeat-containing protein 2.
Protein: PG062_VACCW
Sequence: MNSHFASAHTPFYINTKEGRYLVLKAVKVCDVRTVECEGSKASCVLKVDKPSSPACERRPSSPSRCERMNNPRKQVPFMRTDMLQNMFAANRDNVASRLLN
What is the function of this protein?
Plays an essential role in virion assembly and morphogenesis (PubMed:20392848).  Also plays a role in the inhibition of host immune response by dysregulating mTOR.  Sequesters host RICTOR and RPTOR, thereby disrupting mTORC1 and mTORC2 crosstalk.  In turn, blocks the host antiviral response in part through mTOR-dependent degradation of cGAS, the primary poxvirus sensor (PubMed:30078703).
What are the official names of this protein?
Phosphoprotein OPG062, Phosphoprotein F17.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG062 family.
Protein: RSMH_ECO55
Sequence: MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.