Protein: CMK1_CAEEL
Sequence: MPLFKRRDGSGPAPNATIREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNTAYTHDIHGTVAVHLKKSLAKRNWKKAYNAAAAIRQLQMLRLSSNSNRLQKQASQQQPEPPTPAFHA
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation (PubMed:10428833, PubMed:12231504, PubMed:26725111).  Transcriptional activation occurs at least in part through phosphorylation of crh-1 (PubMed:10428833, PubMed:12231504).  Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons (PubMed:10428833, PubMed:14711416, PubMed:25467978).  Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature (PubMed:25467978).  Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious heat and controls neuropeptide release from FLP neurons in response to temperature elevations (PubMed:25467982).  Regulates the dauer decision, the decision of the larvae to enter into the alternative stress-resistant and long-lived dauer developmental stage, based on the feeding state, primarily in the AWC sensory neurons.  Acts non cell-autonomously in the AWC neurons to regulate expression of the daf-28 insulin-like peptide and cell-autonomously in the ASI sensory neurons to regulate expression of the growth promoting daf-7 in a food-regulated manner (PubMed:26335407).  Plays a role in memory-based thermal response of an individual AFD neuron cell (PubMed:26725111).  Involved in chemotaxis response in AWC neurons to attractant 2-heptanone, a volatile organic compound emitted by the nematode pathogenic bacterium B. nematocida B16 (PubMed:27660389).  Plays a role in a type of aversive gustatory associated learning called salt avoidance learning via regulation of crh-1 signaling and the promotion of long-term memory formation (PubMed:30779740).  Represses transcription of glutamate receptor glr-1 in the nucleus basally and in response to change in synaptic activity (PubMed:27462879).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type 1, CaM kinase I, CaM-KI.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localization is regulated by temperature in thermosensory neurons (PubMed:25467978, PubMed:25467982). Localizes to the nucleus upon elevated temperature shift (PubMed:25467978). Translocates from cytoplasm to the nucleus of FLP thermal nociceptors during thermal adaptation (PubMed:25467982). Translocates transiently from cytoplasm to the nucleus of AWC sensory neurons in response to food withdrawal. Prolonged starvation results in cytoplasmic enrichment (PubMed:26335407). The distribution between cytoplasm and nucleus is regulated by synaptic glutamate receptor glr-1 levels in PVC neurons, accumulating in the nucleus with increasing glr-1 (PubMed:27462879).