PharMolix/UniProtQA huggingface dataset:
Protein: MLF1_HUMAN
Sequence: MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK
What is the function of this protein?
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.  Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels.  Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.  Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
What are the official names of this protein?
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1.
What is the protein family that this protein belongs to?
Belongs to the MLF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.
Protein: HCP_RIPO1
Sequence: MFCEQCEQTASGNGCHQWGACGKSPEVNAVQDLLVYCLRGLAPVVLKAKELGISTHQADVFTGEALFATMTNVNFDKKRFTKYIRDCITIREQLKAAINQPVAWTDICCYQPNFNESLVEQGQNVALTLISQATNNLDIFSLKLTVLYGIKGCASYNFHAQELGQEDEKVYSFIQEALASLDRNDLSLNDWVNLALKVGETNLKAMELLDAGHTSTYGHPTPTSVPLNPRLGKALLVSGHDIKQLAAILQQTANTGLTIYTHGELLPAHGYPILKQKYPHLYGHYGTAWQNQTKDFAKFPGAIIVTTNCLMPPHETYDEKLFTIGPVGYQGINYLASDETGTPDFTPAIEKALSMPGFTTEETPRNVMVGFAHDAVLKVADTVIEAVQQGKIRHFFLVGGCDGAKPGRTYYTEFVEKVPKDCIVLTLACGKFRFFDKQLGSIGTLPRLMDVGQCNDAYSAIKIALGLANAFNIEVNQLPLSMILSWYEQKAIAVLLTLLYLGIKDIRLGPTLPAFITPNLFKLLSETYNLQSITTPEKDLAACLA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_METVS
Sequence: MDEYKKAEILIEALPYICKFHDQKFVIKYGGHAMVNEQAKNWIAKDMVLLKYVGINPIIVHGGGPEINRAMEKMGKVPEFIHGLRVTDEETLEIVKMVLIGKINGDIVSKLEQYGGKSVGLSGKSGQLIKARKKIQYLIRDNEKIEVDLGMVGEVERVDTKLVDILVEKKYIPVISPIGVDEQNKDLNLNADIAAGDIAGAMNAEKLIMVTDVDGIMDDINDPKTLHRKLTISQIEKMIEKGIITGGMIPKIEACINALNKGVQSVHIVNGKIPHAVLLEIFTEEGIGTMILKD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_NATTJ
Sequence: MHPELDLVYVGKIVGTHGVKGELKVISLTDIENRFNELDRVYLVNEQDHYDPIIAHIESSFTHKNMEIVKFSEWDDINQVEGFHDWYIKIPREERPQLEEDEYYFDQITGLSVVTVEDEFLGTVTNIYQTGSNDVYEVSKEQDDKPILIPALYEVVKKIDLDEQIMIVDLPEGLLDEEE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCP1_HELAM
Sequence: MILVALALVALAVAAPPAEEPVQILRSEFNQQPEGSYQFGFETADGISRSETGDVKEALDEENKPHKVVVVRGSYSYTDKEGNPETVNYFADETGYHAEGSSIPKPARK
What is the function of this protein?
Component of the cuticle of the larva of Helicoverpa armigera.
What are the official names of this protein?
Larval cuticle protein 1.
Protein: OBE4_ARATH
Sequence: MKRLRSSDDLDFCNDKNVDGEPPNSDRPASSSHRGFFSGNNRDRGEDAAGFSRAFSRRRSNRDLDNHRPDARYHRSESACFSRRAFPKGFRSERERPNRDASVSSWRRFGGPGNDFGVDDRDRRLRDAERDRSLKSPSWSRDSPNELSKFKPLDSRNSRSRSKSLASPTWSKDSGSEQSKSVGNVVKKSEEEVQGKSSTTSSEMEEGELEPEPQPETASGLAHQTKHDCKLPSCSADDHKNARIDRSFQEIGKSAQLDANTESNRELSHVGGNREMETTDSMTDKKSVEDAENVPEHATESMHVSQNNVNDTSTALAIEHDHRDGTITASANKITDTVDEKGDKDEDYKENLHGVKLEETLYPDVPERLEELKEVKGNDGDANKAEVEGPECVEENALANRTPAEYISSVSDSSVHKCKDKGKNSDVPLTHLVGNALFSESKTEDLHDKDKDEKDDNFGGPSIRGFELFSSSPVRRAKKTEQSGVNKHKDEKLLLEPLDLSLSLPDVLLPIGGQDTNQLGSPVRSGSVRSLTDTFCTNSDGFTMSMSFSGSRSFNHNPSCSLSHNIGDNEQSVHSRPIFQGIDWQALSHNDSKYNENTVYQRLMENGNGSVQPRAMKGNLISGQADEEHLRLPDGSSKAANILEKQLSFQKSVDVRSACPRTGSLENGSKFTVEKKTAKDFYSGSNSWITGLEAGGHDFVETVIRYILSDSMPVMTKRFHEMPTRNITSLKENIRQMMLNMDKNVQLGAFQDALQNRTDITLELLTKSHRAQLEILVALKSGRSDFLLLDNSISSSHLAEIFMNMRCKNLSCRVLLPVDECDCRVCSRKDGFCSACMCLVCSNFDMASNTCSWVGCDVCLHWCHTDCGIKESYIRNGINASGAPGMTEMQFHCVACNHPSEMFGFVKEVFLNFAREWKFERFCKELEYVNKIFSSSKDSRGKQLRQAADAMLASLKSKLIGLPEACNRILGFISDCDSSTPAETSAPFIYEQPKPRHERGSPSQDTAWLRSVCSDNPHNQLKRSASVADAFHRERQVEICAVEMELERGSPKEPRFEELESIVRMKQAEAEMFQGRADDARREAEGLKRIAIAKKEKIEEEYNRRMGKLSMEDAQERRRRRYEELEAMQRGQREFYEMKMRMEEEMRGLLTKMEMTKQSLAL
What is the function of this protein?
Probable transcription factor that functions redundantly with OBE3 in specification of the hypophysis and establishment of the embryonic root (PubMed:22378640).  Involved in the activation of ARF5/MP-dependent gene expression during embryonic root meristem initiation (PubMed:22378640).  Involved in shoot meristem homeostasis (PubMed:27196372).
What are the official names of this protein?
Protein OBERON 4, Protein TITANIA 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL4_PAPAN
Sequence: MGLTSQLLPPLFFLLACAGNFAHGHNCHIALREIIETLNSLTEQKTLCTKLTITDILAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEASQSTLEDFLERLKTIMKEKYSKCRR
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCOP_AZOBR
Sequence: MAQKEKDALSGVETTGHEWDGLRELNNPLPKWWLYIFYVCIAWSLVYYVLYPAWPLGKSYTKGLLGYSQREELVQKVADGKKAQEKYLTAIAATSVEDIQKNKDLLAFAMAGGRSYFNENCAACHGAGGQGAKGFPTLADDVWLWGGTTADIYKTIQHGIRADDGDTRGTVGIGMTAFGRDGILNRDQIGQVAEYILSLNKRSTDAAAAEKGKTVYDENCAACHGENAQGSLAVGMEVGAPPLVTGNWLYGGDKATLVQTITNGRAGVMPAWSKRLDDATIKSLAVYVHNLGGGK
What is the function of this protein?
C-type cytochrome.  Part of the cbb3-type cytochrome c oxidase complex.  CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit.  From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place.  The complex also functions as a proton pump (By similarity).
What are the official names of this protein?
Cbb3-type cytochrome c oxidase subunit CcoP, Cbb3-Cox subunit CcoP, C-type cytochrome CcoP, Cyt c(P), Cytochrome c oxidase subunit III.
What is the protein family that this protein belongs to?
Belongs to the CcoP / FixP family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SUFE_ECO24
Sequence: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRAEDRSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APYP3_PLECI
Sequence: VYINKLTPPCGTMYYACEAV
What are the official names of this protein?
Antiviral protein Yp3.
Protein: TRMB_DECAR
Sequence: MSDTPLIQPANVGEGVYEEGREGYGHIKSYVRRAGRMSSAQENYYAEMMPKIGLVYASQPIDLAAFFGRNNPKVLEIGTGMGETTAKIADANRDIDYLGVEVHVPGVGALCKQIAERELTNLRICQHDAVEVVRDMLPEDSLDGVHVFFPDPWHKARHNKRRLIQSPFVALLASRLKPGGYFHCATDWEEYAHQMLEVLSGEPTLVNSSEGFAPRPDYRPLTKFENRGLRLGHGVWDVIFRKKQLA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MDM12_ZYGRC
Sequence: MSFDIHWSNLESDTRLNESIKNHLNTYLESISLPSYVCNLRILDFSLGKTAPNITLREISDPLDELYRGLNEDEPDSITPSPNDIQFLVEVEYKGDLLVTLAADLVLNYPSDNFMTLPVKLTISNVGLHSLCLVAHLSKHLLISFLCDISDVDLDGNESLLDPKGHVLSPRRSLERISIIRNMKIETEIGQQHSGEGSVLRSVGRLEQFLLEIFKDLLRKEVSWPSWIELDFNDDNEEDLQQSKDTPTTANTGTTTTN
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: Y8H9_ENCCU
Sequence: MEKYENIKQVGEGAFGQVYKSRRTSDGAVFAIKKMPVDRETGFPFTAIREIKLCKSVINKHIIGLDEIVFEEGFIFVVLEYMPYDLTGLLASGAKLSTDQIRSITSQLIEAVSSMHGMGLVHRDIKPSNILLDCHGMLKLTDFGLTREISGMMTNRVCTLWYRAPELLLGETSYSLKVDAWSVGCIMLEMRLGRPPYRGSDEVSQIKLIFEELGIPQDKYKWSDLLDVDIYSKSRSTEEIIAERYGHLFDEEELKVLSGFLCLTSRKRLSVANSRYFTVISSHKNTYIPLSFEEAHELYTKERKETKKP
What is the function of this protein?
May play a role in the control of the eukaryotic cell cycle.
What are the official names of this protein?
Probable cell division protein kinase ECU11_1290.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPA12_DICDI
Sequence: MCTRNKKDITTEYLNSKKIDRELKQESTTLQPLKLLLLGSGECGKSTIFKQIISFQDEATKKEYTPPSDYVIKNIFLNILTATSTFVRVAPSYNIEFSEEENQKIQSILNVFSDLENLDQTVFTSVSDNIKYLWNSKQIQSIYNNTNRIFQLNDSTEYLMSNIDRYSKPFKPTQNDFLRVRVKTTGIVEADFKIEAVPFKLVDVGGQKNQRRKWIHCFQDITCVLFVTSINDYDTLLEEDNSTSRFTDSLELFREMVNSNWFTKSPFVLFFNKIDLFKEKIKRIPVSQHLKDFNGNDHSYEETSQFIKNKFHTTIKNSNKIVYHHFTCALDSRAIEVVFNSIQHSLLMNVAEIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-12 subunit, G alpha-12.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: TIG_CHLTR
Sequence: MSSRDFSNDLFSINIEENAGCVVSAKVQANPLVTQKCHKEALKTVKKNVVLPGFRKGKAPDNIVESRYSTQMEQELRRLFLRASFEALSQMCDRKPLSPKAVRSSAIDTCNPVNGGSVSFLYEAFPVIPSLPWEQLSLPDPEPVKEISEEDLENGLKNVAYFFATKTPVTRPSQEGDFISLSLYVSKRGDENSTPVAIFENKYFKISEEDMTDSFKARFLNVSTGHRVEEEIGSEDIQSFLNGDLLTFTVNAVIEISSPEMDDEKARQLQAESLEDLKKKLRIQLENQAKEAQHQKRFSDAEDALAQLIDFDLPESLLQEREELLSREKLLNARLVKYCSDSELEEQKQALLEEAKADARKAVKLLFLTQKVFSEKGLSISREELQYMMDVCSRERFGGYPPKDISNEMIQELVLVARDRLTYRKAIEAISSEKKDLEVVPS
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: GUAC_LACLA
Sequence: MNNLNSVFDYEDIQLIPNKCVINSRLEADTSVKLGNFTFKLPVVPANMQTIIDDKIAEMLAKEGYFYIMHRFEAENRAAFIKKMHQQGLIASISVGVKADEHAFIREISADALIPEFITIDIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDIAKSIRMGATMVMVGSLFAAHEESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSISYAGGRDLSALTKVDYVVVKNSIWNGDAI
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: QUEA_NEIM0
Sequence: MDISDFDFTLPEKLIAQHPPEVRGSSRLLVALPDMPLQDRVFGDLPDYVEAGDVLVFNNTKVMKARLFGQKDSGGRIEALIERVLDSHTALAHIRSSKSPKPGMGLVFEGGIRAVMVGREGELFCLRFEGGETVYELLEQNGHLPLPPYIERAADADDDSRYQTVYAKYQGAVAAPTAGLHFTEELLRRLKDKGAVTAEVTLHVGAGTFQPVRVDKIEEHKMHSEWFEVPSETAAAVEAAKARGNKVWAVGTTSMRALESAARATGRLKAGQGDTDIFITPGYRFNVVDRLVTNFHLPKSTLLMLVSAFSGMGHIRAAYRHAVEREYRFFSYGDAMVLGRNEGVVR
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTB_SULAC
Sequence: MYPPEFSYVRAESLQEALKFLEGNDNTRPLAGGQSLIPMLKLRVLSPDYILDINRLNELNYVKTSLNGVSIGALTRYHDILSNDIVKSKVPLMHHATRTIGDMQVRNMGTIGGAISNADPASDMPVVLTALNATIILSSASGSRSVKALDFFKGPFTTDTNKGELVTQIEVPVLDGYKTVYKKVVRRAGDYALASVALAIKLKGNEIEDIKLAYGGVHDKPFRAMEVEKNVIGKKLNDDLVKDIASKVSSQINPPSDHRGSSWYRREVVKVLTMKAFKEVA
What is the function of this protein?
Component of the glyceraldehyde dehydrogenase which is involved the nonphosphorylated Entner-Doudoroff pathway.  Catalyzes the oxidation of D-glyceraldehyde to yield glycerate.  When the artificial electron acceptor 2,6-dichlorophenol-indophenol (Cl2Ind) is used, the enzyme shows a broad substrate range (glyceraldehyde-3-phosphate, formaldehyde, acetaldehyde, propionaldehyde and isobutyraldehyde), but is most active with D-glyceraldehyde.  It is not known which acceptor is utilized in vivo.
What are the official names of this protein?
Glyceraldehyde dehydrogenase medium chain, Glyceraldehyde dehydrogenase subunit B, Glyceraldehyde dehydrogenase subunit beta.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF42_ARATH
Sequence: MNWELCDDYPSKAPPETCNKVDGARRCRTSCNNEGYGGANCNLKGKVKVCECTILRVCLPHHKRPPHVPKPPK
What are the official names of this protein?
Putative defensin-like protein 42.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
Protein: MAFB1_TOXGO
Sequence: MWRIWRCRLSFLFATGCLLGALTAGLGSQMSDSVGRNVQAPAGVADASQEAGDVVEERTERTEEQAFALGPPRRHSSESLFPRNASVTARRRRNRRIALIATAVGVAVILAAVYVLRRRRAQRPQDPEPPAPRSVEDPEVLPEEDEASSSLPPPPPPSPPPPPPVEDPLSPESQTVDLSCLSGTTVRFFGPSHHFGGFTPLYDPAPDKRVATVDAGANALFIGGGGLNGQFAKTLLEEAEKHGIRLTPEELSQHSQRIQQSLLRRAVKSPGKLVELDTGVASPVFARSFGFVPVVPGLMWEESEVGPNVGVTFVHILKPEVTPYGNLNNNVMMYTVAPSGAAPDKTYSLAYKTTIAGVIGAAAAYNDTPAGQQYPVQGLRLPLLGGGIFRRNRSLESIGRANAEGTSLAITRYGPNFELQYMYDPSNAALHGLQEAESTYLASMLD
What is the function of this protein?
During host cell infection by tachyzoites, required for tethering the parasitophorous vacuole to the host mitochondria (PubMed:26920761, PubMed:24781109, PubMed:28567444, PubMed:33723040, PubMed:35025629, PubMed:29505111).  This process, known as host mitochondrial association (HMA), induces the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles containing proteins such as mitofusins MFN1 and MFN2, which normally restrict parasite growth (PubMed:35025629).  Specifically, binds to the host OMM import receptor TOMM70 to interact with SAMM50, a component of host mitochondrial intermembrane space bridging (MIB) complex (PubMed:28567444, PubMed:33723040, PubMed:35025629).  By targeting SAMM50, induces the disassembly of the MIB complex, thereby promoting the formation of SPOTs (PubMed:35025629).  Inhibits host TOMM70 import activity (PubMed:35025629).  Plays a role in the modulation of the host innate immune response to parasite infection (PubMed:24781109, PubMed:30333181).
What are the official names of this protein?
Mitochondrial association factor 1 form b1, MAF1RHb1 allele, MAF1b.
What are the subcellular locations of this protein?
Parasitophorous vacuole membrane; Single-pass type I membrane protein. Cytoplasmic granule membrane; Single-pass type I membrane protein. Note=Localizes to dense granules (PubMed:24781109). Localizes at the interface between the parasitophorous vacuole and the host outer mitochondrial membrane (PubMed:26920761, PubMed:24781109).
Protein: MUTS2_BACCZ
Sequence: MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKIGSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQIRTAESRIREKLENMTRSSNAQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEARVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPNNIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYKLLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQLRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFENAMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: WNT2_HUMAN
Sequence: MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874).  Functions as upstream regulator of FGF10 expression.  Plays an important role in embryonic lung development.  May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
What are the official names of this protein?
Protein Wnt-2, Int-1-like protein 1, Int-1-related protein, IRP.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: HIS6_PSEPW
Sequence: MALAKRIIPCLDVDNGRVVKGVKFENIRDAGDPVEIARRYNEQGADEITFLDITASVDGRDTTLHTVERMASQVFIPLTVGGGVRTVQDIRNLLNAGADKVSINTAAVFNPEFVGEAADRFGSQCIVVAIDAKKVSAPGEAPRWEIFTHGGRKPTGLDAVEWAKKMEGLGAGEILLTSMDQDGMKNGFDLGVTRAISDALGIPVIASGGVGNLQHLADGILEGHASAVLAASIFHFGEYTVPEAKAYMAARGIVVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLG_YERPN
Sequence: MPYLLEMKDITKQFGVVKAVDNISLTLEAGQVLSLCGENGSGKSTLMKVLCGIYPVGSYQGEIIFSGETLQAKNIRETEQKGIAIIHQELALVKQMSVLENMFLGSEWGRFGIMDYDAMYLRCQRMLAQVKLVVDPHTPVSELGLGQQQLVEIAKALNKQVRLLVLDEPTASLTESETAILLDIIRDLRNHGIACIYISHKLNEVKEISDHICVIRDGRHIGTRPASTMSEDDIIAMMVGRELKELYPHEAHHIGEEILRVENLCAWHPVNRHIRRVDDVSFSLKRGEILGIAGLVGSGRTETVQCLFGVYPGRWQGDIFIKGQAATIRTCQQAMKLGIAMVPEDRKKDGIVPVMGVGANITLAALDDFTGAFSLLDDAKEQSIIVQSLARLKVKTSSSELAIARLSGGNQQKAILAKCLLLNPQILILDEPTRGIDIGAKYEIYKLINQLVQQGIAVIVISSELPEVLGLSDRVLVMHQGRIKADLINHNLTQEKVMEAALRSETHVTS
What is the function of this protein?
Part of the ABC transporter complex XylFGH involved in xylose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Xylose import ATP-binding protein XylG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIDD_SYNAS
Sequence: MTSEFFAKILIILIRLYQILISPLFAPCCRFYPSCSEYAIIAVRKHGLSKGSRLALIRLFKCHPFHPGGYDPVR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.