PharMolix/UniProtQA huggingface dataset:
Protein: PACC_ASPPA
Sequence: MSEPQDTTSPSTAAAPITASTSQEQSQTQSPPQVSATTTSSVTATAAAATAAVASPPVNGAARPTEELSCLWQGCSEKCPTPESLYEHVCERHVGRKSTNNLNLTCQWGSCRTTTVKRDHITSHIRVHVPLKLHKCDFCGKAFKRPQDLKKHVKTHADDSVLVRSPEPGSRNPDIMFGGNPAKGYATATHYFEPALNPVPSQGYAHGAPQYYQAHHPPQPANPSYGNVYYALNHGHEAGHASYESKKRGYDALNEFFGDLKRRQFDPNSYAAVGQRLLGLQSLSLPILSGGPLPEYQPMPAPVAVGGGGYSPGGHPPAPAYHLPPMSNVRTKNDLINIDQFLQQMQDTIYENDDNVAAAGVAQPGAHYVHGGMSYRTTHSPPSQLPPSHATATTSAGPMMANPATHSPTGTPALTPPSSAQSYTSGRSPISLPSTSRVSPPHHEGGSSMYPRLPSATMPDSMTAGYPTTSSAAPPSTLGGIFDHDDRRRYTGGTLQRARPEERHLPEPMDLSHDNKDDGERTPPAKPRQAPSSPGRISASLIDPALSGSANEAETMRTAQAATEVAERSDVQWVEKVRLIEYLRNYIASRLERGEYDGDSGMTRESRTPEAGPDGHMEGVETEPVSHPAKSESPVKPEAGGDTVMYPTLRGVDEDGDSKMPN
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity).
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CMTA1_CAEEL
Sequence: MNNSVTRLLFKRLLTLQLCHHFDIIPHRDQSFDCVQMQQPQNETANNFIPSIQLLWSTDPPQIRPDGTYPQAVELFPCFKDKWNTKEEILNIILAANADPKSNCVTVQSSPRPCSSSQFIYPRLDNAWYKNDGYIWKKRTNGKQNREDHLNLKISGHPHISAKYIHSAIVPTFHRRSYSVPDSDCHVLVHYLNVKTNNKIDDQAEEIARSMIENKVFISLSQLHDQLSPIFLQTLNVNQLVAEINEHLKKKGVNLPTSPLPQEPSSSTSRELERRNSCSSAFRKGLSSVALRRQPSANSEIDANHIGTMLKRFGCNGSSSDRISIIQPTMQNFQSIRSHQNHVAMESRSPSGDGDSRPITFEEDASYQQLSIKSSTNVSTPASAFAEKMKIRSGSQESPMGPPSSSSVTSTSLIPIIEMTPSSSSLKGGQKMLVVGGYYRKGHEYKISFGRGRMMPAVLIHAGVLSCVIPPSAKPEVVQIRVFCNGQAISTASEFTYEPQSAHLIKENDDTLVQIFEKIRIMACAFNAYSSIENIQSSSCMESLLANIVQQIDNEVSSQNLNYKTELLNGSAHFPSKTVLHLVASLDYDRLFEALIDLSRKVPACREFDIFARDNDGSTPLHTACKNSASRIARLIISIDSSAIDVVDDRGRTPVEVAPEHSIDMLSDKNNEEERVNATELWVMTNGKAFTTDKILDGKISRAPIAEKPDDLLREATSSYSIMSEMYEGPMLQAGTSRECDEDCESCCDPDSTQQLHVEIAMDTDVHVPDSPKMARLFHAVTSPGIVVPPNARARMADLARQIIEALPDRIKRNSEVSMCPDEEDPGQNHHGGVEPMFYQQASCSMSTDSPNMMDDYFDMMATETRNDIFTEPRSTETTETSASKSAQLFATHCNFFDDRSFASSSTRANTFESDTLDFDKDLGEFFTIHVDRFVDPIQQRLANLKYNDDEQRDVYEAAMVIQRAYRVYRARSTTRRQEDIERRAALKIQGCYRRYKQFCYFKKLHNAAIVVQKHFRMRKRDDKEEGAVEAVIASVPEHPTLDGQSICIQVPKTNSTMLRERAATTIQVAYRYRHRKRQAAARKIQNFMRQNRNNVNIDDGHTQHLIAENACAKRRRYVACPQTSGDQRNKRDSDGERKRDAHHDAPEFIPIGATPSSTTIPHRPTQRHHPWDQLKPPYGCGTLA
What is the function of this protein?
Transcription factor (PubMed:34499028).  Positively modulates neuronal levels of the ubiquitous Ca2+ sensor calmodulin/cmd-1, probably by direct binding to the cmd-1 promoter, thereby regulating Ca2+ signaling, physiology, and behavior (PubMed:34499028).
What are the official names of this protein?
Calmodulin-binding transcription activator homolog 1.
What is the protein family that this protein belongs to?
Belongs to the CAMTA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMY1_CYTFI
Sequence: MLVGKKVQTF
What are the official names of this protein?
Alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: GLPK_STAHJ
Sequence: MEKYIMSIDQGTTSSRAILFDKEGDIKGVAQREFKQYFPKSGWVEHDANEIWTSVLAVMTEVLNENEINADQIEGIGITNQRETTVIWDKNTGRPIYHAIVWQSRQTQSICHELKEQGHEETFRNKTGLLLDPYFAGTKVKWILDNVDGAREKAENGDLLFGTIDTWLVWKLSGGEAHITDYSNASRTLMYNIYDLQWDDELLDLLNVPKQLLPEVKESSEIYAHTKDYHFFGQEVPISGIAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGEEPVKSESGLLTTIAYGLDGKVNYALEGSIFVSGSAIQWLRDGLRIINSAPQSENYATRVDSTDNVYFVPAFVGLGTPYWDSEARGAIFGLSRGTEKEHFIRATLESLCYQTRDVMEAMSKDSKIEVNNLRVDGGAVKNNFIMQFQADIVNTAVERPEIQETTALGAAYLAGLAVGFWDSKDEIANRWQLETEFTPQMSEEDRTKLYKGWKKAVEATQVFKLED
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: EFTU2_THET8
Sequence: MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTFVTAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERGQVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE
What is the function of this protein?
Protects glycyl-tRNA(Gly) from hydrolysis by E. coli D-aminoacyl-tRNA deacylase (dtd) (PubMed:27224426).
What are the official names of this protein?
Elongation factor Tu-B, EF-Tu-B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK1_ECO57
Sequence: MSEQHAQGADAVVDLNNELKTRREKLANLREQGIAFPNDFRRDHTSDQLHAEFDGKENEELEALNIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKVRSQILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDILGKTEVTYGDVTLDFGKPFEKLTMREAIKKYRPETDMADLDNFDSAKAIVESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_STRM9
Sequence: MEDKNIKDDEILDDQNDNQEDVQNQDEEKEIKPKKPKKKVYISDDENAEEIKKRIESLKNKNNNISFRVKPPIFFFLILILMSTLFYFYGNKTALFQEKREISYTQFVTKVKQGDITEIRESQEKLTGIKKVAGKVEVFETNKLTDRLGQDTYLMEISKEKNVNIVVLGTPVSSIITRAIFSFAPLFMLLFFFYFINKKMMGSSGGVIGNPFNIGKGKGKISERPNVKFSDVAGLTEEKEELKEIVEFLKNPARFEKAGARVPKGVLLLGEPGTGKTLLAKAVAGESEAAFFPISGSEFIELYVGVGASRVRELFKDAKKEAPAIIFIDEIDAVGRRRGQNKNGGGGNEEREQTLNQLLVEMDGFDTDQRIIVMAATNRSDVLDPALLRGGRFDRRIEVSRPDVKGRIEILKVHSRNKKLASDVKLEDIAKITPGFVGADLENLLNEAAILAARKNSDEITMEDLDEAVDKVGMGLGQKSKIISKRDKDMLAYHEGGHALAATLIPGANKVHKVTIIPRGDAGGYMMPLPEETLGKTRKQILAEINVLFAGRAGEELMMDDIATGAYSDIKRATELAKLLISSVGMSELGPINYEHSDNGFMLSSDLSNETAREIDLEVRKLLKFKYEETLNLLRDNKETLEKIATLLKEKETVTGSEIRALVSGSSVNEVLELDDEQLEKYY
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: GUP1_MILFA
Sequence: MFKAAMDASNETNPNYPKFAHLLSQGWMFGRKVDNSDQQYRFFRDNFPLLCGLVLLHTSLRRGVNLIAGNHKRTGFDFVFGXDIHLCSTRDEFLPYFDSLGYXIFPFLKYIKRNDVATXTYVDXTAILSLFLNDNYXSCTIWNRFYRSWISEVSFQDGMCFSISHCXRMLSYNLDYIEKRKSASEESNLELKNSSSSLSELDDRERLVAPIPLTDYNFVNYMAYITYAPLFIAGPIITFNDYIYQSDYKAMSSVKDYKRTFIYFLRFAFCILVMEFLLHFMYVVAVSKTKAWEGDTPFQLSMLGLFNLNIIWLKLLIPWRLFRLWSLIDGIDPPENMIRCMDNNFSTLAFWRAWHRSYNRWIIRYIYIPLGGGGKYRILNSLCVFSFVAIWHDIELKLLMWGWLVVIFIIPELAATAIFKNYQHEPWYRHVCALGAVINIWMMMLANLFGFCMGKDGTMSLIKTLFTTAVGLRFLFLSLGALFVGSQVMFELREAEKRRGVNVKC
What is the function of this protein?
Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors.  Acts only on GPI-anchored proteins, but not on free GPI lipids.  Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly.  Involved in cell integrity and apoptosis.
What are the official names of this protein?
Membrane-bound O-acyltransferase GUP1, Glycerol uptake protein 1.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Protein: 075L_FRG3G
Sequence: MDDKFTTLPCELEDYPGSITCPHCSAQITTAVDHVVGKMSWVVCTAITLACLPCCCIPFLCNSTKDVRHTCPKCKQAVFVYKIL
What are the official names of this protein?
Uncharacterized protein 075L.
What are the subcellular locations of this protein?
Host membrane; Peripheral membrane protein.
Protein: HIS8_SHISS
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTQDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLTEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVTQIIAEREYLIAALKEIPCVEQVFDSATNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RL15_STRGG
Sequence: MAENSPLKAHNLRPAPGAKTAKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPFRTEYQVVNLDKLATLYPEGGEVTVADLVAKGAVRNNHLVKVLGQGEISVALQVSVDAVSGSAKEKITAAGGTVTELV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RBL_NEOKA
Sequence: MSQSVESRTRIKSERYESGVIPYAKMGYWDADYVIKETDILALFRITPQPGVDPIEASAAIAGESSTATWTVVWTDLLTACDLYRAKAYRVDPVPNVADQYFAYIAYDIDLFEEGSIANLTASIIGNVFGFKAVKALRLEDMRMPVAYLKTFQGPATGLIVERERMDKFGRPFLGATVKPKLGLSGKNYGRVVYEGLKGGLDFLKDDENINSQPFMRWRERFLYSMEGVNKASASAGEIKGHYLNVTAATMEDMYERAEFSKEVGSIICMIDLVIGYTAIQSMAIWARKHDMILHLHRAGNSTYSRQKNHGMNFRVICKWMRMAGVDHIHAGTVVGKLEGDPLMIKGFYNTLLESDTDINLPQGLFFAQNWASLRKVVPVASGGIHAGQMHQLLDYLGDDVVLQFGGGTIGHPDGIQAGATANRVALESMVMARNEGRNYVAEGPQILRDAAKTCGPLQTALDLWKDISFNYTSTDTADFVETPTANI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFP_STRPC
Sequence: MIEASKLKAGMTFEAEGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTTYRPDEKFEQAIIETVPAQYLYKMDDTAYFMNTDTYDQYEIPVANVEQELLYILENSDVKIQFYGSEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATLETGLVVNVPDFIEAGQKLIINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_DESVH
Sequence: MSITKEQVVEFIGNMTVLELSEFIKELEEKFGVSAAAPMAAMAVAAPAGDAAPAEEEKTEFDIILKSAGANKIGVIKVVRALTGLGLKEAKDKVDGAPSTLKEAASKEEAEEAKKQLVEAGAEVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TONS_ARATH
Sequence: MGRLDVAAAKRAYRKAEEVGDRREQARWANNVGDILKNHGEYVDALKWFRIDYDISVKYLPGKDLLPTCQSLGEIYLRLENFEEALIYQKKHLQLAEEANDTVEKQRACTQLGRTYHEMFLKSEDDCEAIQSAKKYFKKAMELAQILKEKPPPGESSGFLEEYINAHNNIGMLDLDLDNPEAARTILKKGLQICDEEEVREYDAARSRLHHNLGNVFMALRSWDEAKKHIEMDINICHKINHVQGEAKGYINLAELHNKTQKYIDALLCYGKASSLAKSMQDESALVEQIEHNTKIVKKSMKVMEELREEELMLKKLSAEMTDAKGTSEERKSMLQVNACLGSLIDKSSMVFAWLKHLQYSKRKKKISDELCDKEKLSDAFMIVGESYQNLRNFRKSLKWFIRSYEGHEAIGNLEGQALAKINIGNGLDCIGEWTGALQAYEEGYRIALKANLPSIQLSALEDIHYIHMMRFGNAQKASELKETIQNLKESEHAEKAECSTQDECSETDSEGHANVSNDRPNACSSPQTPNSLRSERLADLDEANDDVPLISFLQPGKRLFKRKQVSGKQDADTDQTKKDFSVVADSQQTVAGRKRIRVILSDDESETEYELGCPKDSSHKVLRQNEEVSEESMYFDGAINYTDNRAIQDNVEEGSCSYTPLHPIKVAPNVSNCRSLSNNIAVETTGRRKKGSQCDVGDSNGTSCKTGAALVNFHAYSKTEDRKIKIEIENEHIALDSCSHDDESVKVELTCLYYLQLPDDEKSKGLLPIIHHLEYGGRVLKPLELYAILRDSSENVVIEASVDGWVHKRLMKLYMDCCQSLSEKPSMKLLKKLYISEVEDDINVSECELQDISAAPLLCALHVHNIAMLDLSHNMLGNGTMEKLKQLFASSSQMYGALTLDLHCNRFGPTALFQICECPVLFTRLEVLNVSRNRLTDACGSYLSTIVKNCRALYSLNVEHCSLTSRTIQKVANALDSKSGLSQLCIGYNNPVSGSSIQNLLAKLATLSSFAELSMNGIKLSSQVVDSLYALVKTPSLSKLLVGSSGIGTDGAIKVTESLCYQKEETVKLDLSCCGLASSFFIKLNQDVTLTSSILEFNVGGNPITEEGISALGELLRNPCSNIKVLILSKCHLKLAGLLCIIQALSDNKNLEELNLSDNAKIEDETVFGQPVKERSVMVEQEHGTCKSVTSMDKEQELCETNMECDDLEVADSEDEQIEEGTATSSSLSLPRKNHIVKELSTALSMANQLKILDLSNNGFSVEALETLYMSWSSSSSRTGIAQRHVKEETVHFYVEGKMCCGVKSCCRKD
What is the function of this protein?
Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:35298257).  Specifically recognizes and binds histone H3. 1 lacking methylation at 'Lys-27' (H3K27me1) (PubMed:35298257).  Involved in structural and functional stabilization of chromatin; represents a link between response to DNA damage and epigenetic gene silencing (PubMed:14966212, PubMed:15082530, PubMed:16728410, PubMed:21705754).  Required for cell arrangement in root and shoot apical meristems (PubMed:14966212, PubMed:15082530, PubMed:16728410, PubMed:21705754).  May be involved, when interacting with TSA1, in the organization of spindle microtubules (PubMed:15964904).
What are the official names of this protein?
Protein TONSOKU, Protein BRUSHY 1, Protein MGOUN 3.
What is the protein family that this protein belongs to?
Belongs to the Tonsoku family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Chromosome. Note=During anaphase, relocalizes in spots close to the ends of spindle microtubules ahead of separating chromatids.
Protein: FUS_NDVL
Sequence: MGSRPSTKIPAPMMLTIRVALVLSCICPANSIDGRPLAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNLPKDKEACAKAPLDAYNRTLTTLLTPLGDSIRRIQESVTTSGGGRQGRLIGAIIGGVALGVATPAQITAAAALIQAKQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDWIKIAQQVGVELNLYLTELTTVFGPQITSPAFNKLTIQALYNLAGGNMDYLLTKLGVGNNQLSSLIGSGLITGNPILYDSHTQLLGIQVTLPSVGNLNNMRASYLETLSVSTTRGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRIVTFPMSPGIYSCLSGNTSACMYSKTEAALTTPYMTIKGSVIANCKMTTCRCVNPPGIISQNYGEAVSLIDKQSCNVLSLGGITLRLSGEFDVTYQKNISIQDSQVIITGNLDISTELGNVNNSISNALNKLEESNRKLDKVNVKLTSTSALITYIVLTIISLVFGILSLILACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: GLUQ_VIBVY
Sequence: MLPFCFEMTSMSYIGRFAPSPSGPLHFGSLIAALGSYFQAKSQHGQWLVRIEDLDPPREMPGAADLILKTLETYHLFWDGEVVYQSQRHHLYQAQIDHWLQSGQAYYCQCSRKQIKEMGGYYNGHCQELHLDAGAIRLKMTQPITHFDDLRHGQMHIPLELAQEDFIIKRRDGLFAYNLAVVLDDIDQGVTEVVRGADLIEPTGRQISLYHMLGQVPVRYLHLPLAMDKNGNKLSKQNHATGIDLTHPASMILEAMAFLGFAIPKELHQANLDEILRWGVQNWRLNQLPESLEITARFSNGTA
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: Y361_SYNY3
Sequence: MAERIQKLLSQWGIASRRHAEEMILAGRVSVNGKVANLGDKADPQQDFLSVDGKQIKADNRPRDIYLLVNKPRDVLSTCDDPRGRKTVLDLLPQDLQRGKGLHPVGRLDRNSTGALLLTNDGELTLRLTHPRYHLPKTYDVWLEGNPSDEDLEKWRSGMMLDGKKTLPATLEVISENKDQIHLLVTLTEGRNRQIRRLAEELGLTVLKLHRRTIGPLQLHTRGKVLGSGQFRFLSPAEIRLLKKQVNLR
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase slr0361, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: BUK_BACC3
Sequence: MSVNRILVINPGSTSTKIGVFDNERPVLEETIRHDEEQIGKYKRIIDQYEFRKETILEVLHSHGINISKLNAVCGRGGLLRPIEGGTYTVNDAMLEDLKNGFSGHHASNLGGILAYEIASGLNIPAFIVDPVVVDEMEPIARISGIAGMERKSIFHALNQKAVARKVAEELNHKYEDLNLLVTHMGGGITVGAHKKGKVIDVNNGLNGEGPFSPERAGTVPVGQLVEMCFSGEYYRDEMVKKLVGQGGLVSLIGTNDAIKVEQMVEKGDPEATLIYKAMAYQVAKEIGGASAVLHGKIDAIVLTGGLAYSKILVDEIKERVDWIADVIVHPGEDELQALAEGALRVLREEEAPKEYIVREKETVARG
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM6_YERE8
Sequence: MNLPNIDQIKTYLLDLQDKICAALAQADGSAKFTEENWVREEGGGGRSRVMVKGAVFEQAGVNFSHVSGAALPASATAHRPELAGRSFQALGVSLVIHPNSPYLPTSHANVRFFIAEKPDEDPVWWFGGGFDLTPFYGFEEDAIHWHQTAYNLCQPFGEQLYSRYKKWCDDYFYIKHRNEARGIGGLFFDDLNSPDFDTCFNFTQAVGDGFLDAYMPIVARRKALCWGEREREFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYNYQPAADSAEVALYRDFLPVKDWLAAGEHH
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_LACLA
Sequence: MEKINYLLPEESAEMTLNQVKSLRQIEGRLRKLFSLKNYQEVMPPSFEYTQLYTALESNGKTFNQEKMFQFIKHEGQSITLRYDFTLPLVRLYSQIKDSTSARYSYFGKIFRKEKRHKGRSTENYQIGIELFGESADKSELEILSLALQVIEQLGLNKTVFEIGSAKFFQRLCQLADGSTELLTELLLKKDLSGLNAFIEKNNFSKELRGLLKEIFITNELSRLENLVTNTKDDVLISSFDQLKEFSEKLSMIKPIIIDLGMVPKMDYYTDLMFKAYSSAANQPILSGGRYDQLLSNFQEEAFAIGFCCHMDTILKALERQELEEDND
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL23R_MOUSE
Sequence: MSHLTLQLHVVIALYVLFRWCHGGITSINCSGDMWVEPGEIFQMGMNVSIYCQEALKHCRPRNLYFYKNGFKEEFDITRINRTTARIWYKGFSEPHAYMHCTAECPGHFQETLICGKDISSGHPPDAPSNLTCVIYEYSGNMTCTWNTGKPTYIDTKYIVHVKSLETEEEQQYLASSYVKISTDSLQGSRKYLVWVQAVNSLGMENSQQLHVHLDDIVIPSASIISRAETTNDTVPKTIVYWKSKTMIEKVFCEMRYKTTTNQTWSVKEFDANFTYVQQSEFYLEPDSKYVFQVRCQETGKRNWQPWSSPFVHQTSQETGKRNWQPWSSPFVHQTSQTVSQVTAKSSHEPQKMEMLSATIFRGHPASGNHQDIGLLSGMVFLAIMLPIFSLIGIFNRSLRIGIKRKVLLMIPKWLYEDIPNMENSNVAKLLQEKSVFENDNASEQALYVDPVLTEISEISPLEHKPTDYKEERLTGLLETRDCPLGMLSTSSSVVYIPDLNTGYKPQVSNVPPGGNLFINRDERDPTSLETTDDHFARLKTYPNFQFSASSMALLNKTLILDELCLVLNQGEFNSLDIKNSRQEETSIVLQSDSPSETIPAQTLLSDEFVSCLAIGNEDLPSINSYFPQNVLESHFSRISLFQK
What is the function of this protein?
Associates with IL12RB1 to form the interleukin-23 receptor.  Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.  IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues.  IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity).
What are the official names of this protein?
Interleukin-23 receptor, IL-23 receptor, IL-23R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ADEC_ECO8A
Sequence: MNNSINHKFHHISRAEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYADAPALQRIDARGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYITAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESARLAQSAPPYGNTIARQPVSASDFALQFTPGKRYRVIDVIHNELITHSHSSVYSENGFDRDDVSFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEVTE
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: FLGH_THEMA
Sequence: MRRISIVLLIVFATSIFPFSIWNSAGESEYKNLLSIKKASKVGDILTIVIRESNNVSSERESLEIQKTLLNILGNVVNAAAGVNLNNFIPINNNSPERQRGGKVQSSVVAKISAVVVDIDPYGNLVVEGRKTIKVDKDYQEIIVKGKVRPDDIEIGNEVDSSKLADSEIWVNGKLVFSEEPGKESFFDKILAFLAGLFT
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane. Bacterial flagellum basal body.