PharMolix/UniProtQA huggingface dataset:
Protein: LEUD_STAAT
Sequence: MAAIKPITTYKGKIVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLPDGSDNPDFNPNKPQYKGASILITGDNFGCGSSREHAAWALKDYGFHIIIAGSFSDIFYMNCTKNAMLPIVLEKSAREHLAQYVEIEVDLPNQTVSSPDKRFHFEIDETWKNKLVNGLDDIAITLQYESLIEKYEKSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: NIFH2_METTL
Sequence: MKQIAFYGKGGIGKSTTVCNIAAALADQGKKVMVVGCDPKHDCTSNLRGGQEIPTVLDILREKGLDKLGLETIIEKEMIEINDIIYEGYNGIYCVEAGGPKPGYGCAGRGVIVVIDLLKKMNLYKDLKLDIVLYDVLGDVVCGGFAMPLRMGLAEQIYVVTSSDYMAIYAANNICRGISEFVKRGGSKLGGLIYNVRGSMDAYDIINEFADKLGANIVGKVPNSHLIPEAEIEGKTVIEYDPNDEISQVYRELAKKIYENNEGTIPKPLENIEIMTIGKKIKERLKKERMKN
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 2, Nitrogenase Fe protein 2, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: TMD11_CANLF
Sequence: MPMLAFALSFYFSLSTAFYFHVGEREEKCIIEDIPSDTLVTGTFKTQQWDFRRQDFLESAPGLGMFVTVTTYNDEVLLSKLYGPQGRFYFTSHSPGEHIICLESNSTRLVSFGGSKLRIHLEIRVGQHDLDAAIAQAKDKVNEVSFKLEHLIEQIEQIVKEQNYQRDREENFRMISEDTNSNVLWWAFAQTLIFIAIGIFQMKSLKNFFIAKKLV
What is the function of this protein?
Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins.
What are the official names of this protein?
Transmembrane emp24 domain-containing protein 11, Glycoprotein 25L, GP25L, p24 family protein alpha-1, p24alpha1.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RFAI_SALTY
Sequence: MSRKYFEEEVIQQTLDYNYAQHSDADKFNIAYGIDKNFLFGCGVSIASVLLANPEKALAFHVFTDFFDSEDQQRFEALAKQYATQIVVYLIDCERLKSLPSTKNWTYATYFRFIIADYFSDKTDRVLYLDADIACKGSIQELIDLNFAENEIAAVVAEGELEWWTKRSVSLATPGLVSGYFNAGFILINIPLWTAENISKKAIEMLKDPEVVQRITHLDQDVLNIFLVNKARFVDKKFNTQFSLNYELKDSVINPVDAETVFVHYIGPTKPWHSWGAYPVSQYFLQAKSNSPWSHCALLNPVTSHQLRYAAKHMFNQKHYTSGINYYIAYFKRKLLE
What is the function of this protein?
Adds the galactose(I) group on the glucose(I) group of LPS.
What are the official names of this protein?
Lipopolysaccharide 1,3-galactosyltransferase, Lipopolysaccharide 3-alpha-galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
Protein: DXS_BORPE
Sequence: MTTELLDRILSPADLRQLDRRELKRLADELRGFVLESVSRTGGHLSSNLGTVELSLALHYVFDTPHDRIVWDVGHQSYPHKILTGRREGMAHLRQQGGISGFPKRSESEYDAFGTAHSSTSISAALGMAVASRNAGVQRQHIAVIGDGAMSAGMAFEAMNNAGVTPNINLLVVLNDNDMSISPPVGALNRYLARLMSGQFYAAAKNVGRAVLQHVPPVLELARRLEEHAKGMVTPATLFEEFGFNYVGPIDGHDLDALVPTLQNLRALPGLQFLHVVTRKGQGYKLAEADPVLYHGPGKFDPAVGIQQAKAPARKTFTQVFGQWLCDMAERDERLVGITPAMREGSGLVEFEQRFPQRYFDVGIAEQHAVTFAAGLACEGQKPVVAIYSTFLQRGYDQLVHDVALQNLDVTFALDRAGLVGADGATHAGNYDIAFLRCVPNMVVAAPSDESEARLLLSTCYEHPGPASVRYPRGAGCGAAVGEGLATVPLGKGLVRREGRRIAILGFGTLVQAALGAAGQIDAMVADMRFVKPLDRELVLELAARHDALVTVEEAAIMGGAGSAVLETLAEAGVTLPVLQLGLPDAFIDHGDQAALLAGLGLDAAGIERAIRARFGALLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: XYNC_BACSU
Sequence: MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEKQVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAKSAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNGVNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPILNDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPEALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVRIDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSNLQPGTNLTVSGNHFWAHLPAQSVTTFVVNR
What is the function of this protein?
Catalyzes the depolymerization of methylglucuronoxylan (MeGAXn) from different sources.  It cleaves the beta-1,4-xylosidic bond penultimate to that linking carbon one of the xylose residue substituted with alpha-1,2-linked 4-O-methyl-D-glucuronate (MeGA).
What are the official names of this protein?
Glucuronoxylanase XynC, Endoxylanase XynC, Glucuronoxylan xylanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KBAY_ECOLI
Sequence: MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires KbaZ subunit for full activity and stability.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Ketose 1,6-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily.
Protein: MRAY_SHEB9
Sequence: MLVYLAEYLTRFHTGFNVFSYVTFRAILGLLTALVFSLWFGPKLIERLQLLQIGQVVRNDGPESHFSKRGTPTMGGLLILAAIFISVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKVVRKDTKGLIARWKYILQSLAALLIAFFLYATAANPGETQLVVPFFKDVMPQLGAVFIVLAYFTIVGSSNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHAQFANYLHIPHLPGSGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVMETLSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISIFLVLLGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LITA_LATTR
Sequence: ACSSPEVSIFHFFVYAGSFVKNFKKMKGSSAISKREMSRADQCKLLAYTAVGYETVGNVAADIASIEGANLVAAPVAAGGHLGKGLTDAAMIAMDCSSIPFEEIKEILNKEFKEMGRKLDKNTEALEHVSKLVSKTLSTVEKIRVEMREGFKLVIETIENIATKEIVFDINKIVQYFNNERENINSRQKEEFVAKLQEPAPGNFLLYLRNSRTSESGTLYSLLFRIIDQELAIPNNAGDNNAIQALYALFYGTETFISIMFYLVKQYSYLAEYHYQKGNLEEFNTNFDHMKIVFQDFKFSLIGINQNTKPLVDEVLNVLNNVKNKSFIRNVQNKLFYDLMKQTESLLELKKEIANMELPIIDETPRLSISISFKERSDDKPVDTPLLKWDKGKEVKYAIQFEQDGKFSKISSWSKPVTVQHLACPFISVDKDRRNRLIFRQFGDQIPELVGTLRGSQVEFRDIHRDLYNAAQVPYAREALSISRTLIQNGANVSETFELGRGAIHAAASAGNYDVGELLLNKDINLLEKADKNGYTPLHIAADSNKNDFVMFLIGNNADVNVRTKSDLFTPLHLAARRDLTDVTQTLIDITEIDLNAQDKSGFTPLHLSISSTSETAAILIRNTNAVINIKSKVGLTPLHLATLQNNLSVSKLLAGKGAYLNDGDANGMTPLHYAAMTGNLEMVDFLLNQQYININAATKEKKWTPLHLAILFKKNDVAERLLSDENLNIRLETNGGINPLHLASATGNKQLVIELLAKNADVTRLTSKGFSALHLGIIGKNEEIPFFLVEKGANVNDKTNSGVTPLHFAAGLGKANIFRLLLSRGADIKAEDINSQMPIHEAVSNGHLEIVRILIEKDPSLMNVKNIRNEYPFYLAVEKRYKDIFDYFVSKDANVNEVDHNGNTLLHLFSSTGELEVVQFLMQNGANFRLKNNERKTFFDLAIENGRLNIVAFAVEKNKVNLQAAHRGKTILYHAICDSAKYDKIEIVKYFIEKLNESECNPLHEAAAYAHLDLVKYFVQERGINPAEFNEENQASPFCITIHGAPCGYSLDCDTPDRLEVVEYLSDKIPDINGKCDVQENTPITVAIFANKVSILNYLVGIGADPNQQVDGDPPLYIAARQGRFEIVRCLIEVHKVDINTRNKERFTALHAAARNDFMDVVKYLVRQGADVNAKGIDDLRPIDIAGEKAKAYLQSSRFLRSGHSFQSNEIDSFGNTIHGISMSARTNDKLTQQISSKGTRSDSNSTEGKMHSENVHVRSIDVNGALLLLDFMIRVFASKKTNFAPYGSRIKTRSAAEAQAEALIMTERFENLLSGLIGDPIPDSIDFSNVHSKIYKAIMSGRRSVISEMLCSFAEEYSKLNHESIKQLLSEFETLTTTKASEIHIEESVPYAPFEICELKVNSNVSQIK
What is the function of this protein?
Insecticidal presynaptic neurotoxin that induces massive neurotransmitter release at insect (but not vertebrate) neuromuscular junctions.  Native toxin forms cation-permeable pores (with high permeability to calcium) in lipid membranes locust muscle membrane and artificial lipid bilayers (By similarity).  May bind to insect neurexin-1 homolog, insect adhesion G protein-coupled receptor L1 homolog, and insect receptor-type tyrosine-protein phosphatase S homolog, and induces neurotransmitter exocytosis both by forming tetrameric pores in membranes and signaling via G protein-coupled receptor (By similarity).  Oligomerization is a process independent of divalent cations (By similarity).  The toxin forms channels with 0. 55-0. 58 nm entrance diameter and a relatively small conductance in planar phospholipid membranes (PubMed:17764656).
What are the official names of this protein?
Alpha-latroinsectotoxin-Lt1a, Alpha-LIT-Lt1a, Alpha-latroinsectotoxin, Alpha-LIT.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 01 (latrotoxin) family. 02 (alpha-latroinsectotoxin) subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a membrane channel in the prey.
Protein: P85B_MOUSE
Sequence: MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGSSESGHILPDLAEQFSPPDPAPPILVKLVEAIEQAELDSECYSKPELPATRTDWSLSDLEQWDRTALYDAVKGFLLALPAAVVTPEAAAEAYRALREVAGPVGLVLEPPTLPLHQALTLRFLLQHLGRVARRAPSPDTAVHALASAFGPLLLRIPPSGGEGDGSEPVPDFPVLLLERLVQEHVEEQDAAPPALPPKPSKAKPAPTALANGGSPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQVVKEDSIEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPSAAR
What is the function of this protein?
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3).  PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.  Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.  Indirectly regulates autophagy (By similarity).  Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).
What are the official names of this protein?
Phosphatidylinositol 3-kinase regulatory subunit beta, PI3-kinase regulatory subunit beta, PI3K regulatory subunit beta, PtdIns-3-kinase regulatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regulatory subunit p85-beta.
What is the protein family that this protein belongs to?
Belongs to the PI3K p85 subunit family.
Protein: MIAA_MICAN
Sequence: MTTSSLPILIVICGATATGKSSLALQLAEKFNSVILSADSRQIYREFNIGTAKPSLEECQRIPHYLIDICDPQDNFTLAQYQEQAEDLINNLHYSPLFLVGGTGLYIKSIVKGLKIPRVSPQADLRRQLQALGQSYLYQILTQVDEEAAKKIHPHDQVRTLRALEVFYLTGKPISSQQGENPPTYPILQIGLDCSPESLGKRITVRTDQMIARGLVAEVQNLGDKYGWDLPLLQTLGYAEIKQYLLGEISLEQAIDLIILHTRQFAKRQRTWFRADADIIWFPVDKENLLESVEREIILFLEGLSRPDIKTHHPD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: EGG1_SCHJA
Sequence: MKSSLTLLFLAAIGYTIAYPPPSDYDSGYGGGGGGGGGGGYGGWCGGSDCYGGGNGGGGGGGGGNGGEYGGGYGDVYGGSYGGGSYGGGGYGDVYGGGCGGPDCYGGGNGGGNGGGGGCNGGGCGGGPDFYGKGYEDSYGGDSYGNDYYGDSNGRKNGHGKGGKGGNGGGGGKGGGKGGGNGKGNGKGGGGKNGGGKGGNGGKGGSYAPSYY
What are the official names of this protein?
Eggshell protein 1.
Protein: MURA1_STAAC
Sequence: MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTTLNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCAIGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLAKGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAGTLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTLPHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGKSQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIND
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y383_RHIME
Sequence: MSVKPAALFRISAALAVAGLGASLIASAALAQATSSRMQGLQLSNDQPIQIESDKLEIKDPESKAIFTGNVKVVQGTTTLQAGNMTVFYKAGGGSVTSGNADIDRIEVSNKVFLSSGAQQATGESGIVNLTNQTIVLKGKKVVLSEGKNVFVGCQLNVQMDTGEAQLDACGGRVQIQLDPQSRKTN
What are the official names of this protein?
Uncharacterized protein R00383.
Protein: RL33_SODGM
Sequence: MAKGVREKIKLVSSAGTGHFYTTTKNKRTKPEKMELKKFDPVVRQHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RNF17_MOUSE
Sequence: MAAEASSTGLASCHLVESKSGAQGASGCQCTRCGRKVSVASGDHHKFPCGHAFCELCLLAPQEYTTSKCTDCEVHTTVSMNQGHYPVDGFIEEDSSLEALPPKMVNNCSSDLEKTVDQLINDLEHSSSIHRNVSNPSAVMSETEEIDEALKIAGCNFEQLSNAIKMLDSTQDQTRQETHSLTEAVEKQFDTLLASLDSRKKSLCEELIRRTDDYLSKLVTVKSYIEEKKSDLDAAMKIAKELRSAPSLRTYCDLTQIIRTLKLTFESELSQVSSIIPRNTPRLDINCSEAICMFSSMGKIEFEDSTKCYPQENEDGQNVQKKFNNRKELCCDVYSSLEKKKVDAAVLTDETPEPPLQAEAPDRHLEGKKKQPTKEMVVVTSPKTIAVLPQLGSSPDVIIEEIIEENLESCFTDDPIETSGYPKKPPQKEQSAPVGSKAGCPELVFVSHVIHPCHFYVRKYSQIKDATILEKKMKQVCNRSLHLDPSDILELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHEGPEHDGEQHITLSDFCLLLMKSEPYSEELLKDIPHLAHLCSLKDIVPYNSTEGWEKEAKVEFLKMVNKKAVLMKVFGEEDDVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQSPRSHSEKNTTLCYHPPILPEEMTEVSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSQWSKKAKEKFEEKTQDKFVTCSVIKILENNVLLVELFDSRAPGKSAVSINDQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEIITSEINNLSPLSVKSLPNENFQSLYNKELPVNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLHLTGAIATIILQESNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRERRVSKSSNSHSPEKSLEIPLEQGDSVVTKCFKINFDTNKKIADKVNEHKVPDSKGKKSESRSTGCYRPPAVPNTSSFEAIVTCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYQTLPVGNTWQPDAIELLQELLSKREVDIHIMELPNNSWGKLSVHLYFDGMSLSHFMAHHKYCIFEHTEEIFKEKPRGQNKKYEDENWKIRFEDLLLPEMEAPVLPPYLSSLLPPPEELFAVQVKHIVSPDEMYICLDSEDSYTQFNHHGDTDDSGVSWESESENLEEALQRFNKNVETFPPLTDFSSEMPCLAEYADGLWYRAKIISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPPLSDSGKTRIPYCPKWSMEALWTMIDCLQGKQLYASSVAQAPEQIVTLYEDEQYPVHMSLVEMGLADKDE
What is the function of this protein?
Seems to be involved in regulation of transcriptional activity of MYC.  In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers.  Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm.  May be involved in spermiogenesis.
What are the official names of this protein?
RING finger protein 17, Mad member-interacting protein 2, Mmip-2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron- dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids).
Protein: MYOF_MOUSE
Sequence: MLRVIVESATNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDSSSSLVIVVKDFETIGQNKLIGTATVSLKDLIGDQNRSLPYKQTSLLNEKGQDTGATIDLVIGYTPPSAPHPNDPSGTSVPGMGEEEEEDQGDEDRVDGIVRGPGPKGPSGTVSEAQLARRITKGKSSRRMLSNKPQDFQIRVRVIEGRQLCGNNIRPVVKVHICGQTHRTRIKRGNNPFFDELFFYNVHITPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGAKGYMKVSMFVLGTGDEPPPEKRDRDNDSDDVESNLLLPAGIALRWVTFMLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIERNANPEWNQVVNLQIKFPSMCEKIKLTVYDWDRLTKNDVVGTTYLYLSKIAASGGEVEATTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNSGKGEGVAYRGRIFVELNTFLEKKPPEKKLEPISSDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDATCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLVMAERLQSNIEAVKSGIQGKIPANQLAEVWLKLIDEVIEDTRYTLPVTEGKANVTVLDTQIRKLRSRFLSQIHEAALRMRSEATDVKSTLLEIEEWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGGNASGKYCGKTQTILLKYPQEKTNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALVFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGDWVVDPERSLLTEADAGHTEFTDEVYQNENRYPGGEWKQAEDTYTDANGDKAASPSEMTCPPGWEWEDDAWIYDINRAVDEKGWEYGITIPPDNKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELEDREGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGEEKGPEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYIYQARNLMALDKDSFSDPYAHVSFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIFGEPQTVLQNPPNVTIELFDNDQVGKDEFLGRSICSPLVKLNSETDITPKLLWHPVMNGDKACGDVLVTAELILRNKDGSNLPILPSQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNYQMASVTSPSLVVECGGERVESVVIKSLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIDHLDRFRCDPYAGKEDIVPQLKASLMSAPPCREVVIEIEDTKPLLASKLSEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYDCELEDVADFEGLTDFSDTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVQGLQLQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETTIDLENRFLSRFGSHCGIPEQYCVSGVNTWRDQLRPTQLLQNVARFKGFPPPVLSEDGSRIRYGGRDYHLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEDMSDIYVKGWISGSEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRVPPRLIIQIWDNDKFSLDDYLGFLELDLHRTIIPAKTSEKCSLDMIPDLKAMDPLKAKTASLFEQRSMKGWWPCYADKDGTRVMAGKVEMTLEVLNEREADERPAGKGRSEPNMNPKLDPPNRPETSFLWFTNPCKTMRFIVWRRFKWVIIGLLLLLILLLFVAVLLYSLPNYLSMKIVRPNA
What is the function of this protein?
Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress.  Involved in endocytic recycling.  Implicated in VEGF signal transduction by regulating the levels of the receptor KDR.
What are the official names of this protein?
Myoferlin, Fer-1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the ferlin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Nucleus membrane; Single- pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures (By similarity). Concentrated at the membrane sites of both myoblast-myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels.
Protein: DOLK_MOUSE
Sequence: MTRQCPPQESGAALSGSVLAEAAVVFAVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGVIIYIMRHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIRRNPLLWLLQFLFYTETRIYLLAYWSLLASVACLVVLYQNAKRSSSESKKHRAPTITRKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKDSLEGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
What is the function of this protein?
Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis.  Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors.
What are the official names of this protein?
Dolichol kinase, Transmembrane protein 15.
What is the protein family that this protein belongs to?
Belongs to the polyprenol kinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ADA2_DICDI
Sequence: MFLKFKNIFFIVLTLSIVFNGLIVNSKNIHINNKNNNNNNNNKDLSSSESGSSSDINPYISQYNSERETLVNQENQIKLGSNTPFNSKEQQANTIFLNILQNEELSFSNNDPSGVNFFIEKQIIENESTIFKIIQNMPKGSALHVHQDSSATYDYLISVGSYLPNCYIYLTYDVNDANNGTFHFYDSQPTDSNWKLLSTIREGVSNVESFDQQLLDSLTLIGQDYGDYVSLWRKFDGIFGRVNGLVTYLPIATGYMEHLFQQMIQDGVQHIEVRKCFGDFYDLTGKIYDDYWFVQTMEELVLTTRQKYNMSEFALKIIGCNGRHNNQSVVYDAMVMSLDLRNKYPSTFVGYDLVGPEDEGYPLIYFIEQFAEIKKLGYQYQYPLDYYFHAGETILYNNTNLYDAILLNTKRIGHGIQLPKHPLLMDLVLKNDIGIEICPISNQILQYVSDMRAHPGLDLLNRGLPVTISPDDPAIFNYGGLSYDFFELTYSWGLNLQQLKQLAINSINHSNTFNQSEYNLLYNAWEVKWFNFIDYIINTYSNI
What is the function of this protein?
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses.  May play a role in the regulation of cell proliferation (By similarity).
What are the official names of this protein?
Adenosine deaminase 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YND3_YEAST
Sequence: MLYSRESRTTVLFLALVTSLTVLCHSVDVTTVFTTSTITEITTVTAAPQPQNKAETALNTATNIIQTMQFLFNCAPFKWKGPLKITSCALNFIVLLLTAWGYLLKYLQENKLNSDADMEKMVGLGFGEMVGRIFGKGVGKAFTKMDITQKLVYPFEGSNRQKCLLMTVGENSIVPFHDLFTEICFDQYTLDSLSHHNHGSISILDAGSVSALGFADISSKMPSVSELYTLFGDYTIEVLGGITKLASTLNREDWQGERNGFAVLSRDRPNQTLLSVHMYSSSLL
What are the official names of this protein?
Uncharacterized membrane protein YNL033W.
What is the protein family that this protein belongs to?
To yeast YNL019c.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: BRE1_ASHGO
Sequence: MEEPAAKRPKLSDRSEPLTQRDVVLFQKEALFRQLNRYRAEARAGQVQVEELRRAHGQVGERLAAVCGVVRSVARAVADARGDGDARALCERVAGGDDDEVVARAAEFAAVVAGGLGRGAAAGEGWHRLEAVNSRLAAENAQLAAELGAVRGFYAELLRRYDRDESETVRRVFKVEESEPPRAATPVEESSAKGAASDGEAATAVVEREMQIEELQTEIRVLEDTVAQLTDWKRLNEQELTKLRQMASSAELSQRHPTPPSSSNLSADLQVLRSKVEKLSHENKELAQLNEAYLGKFQQLSADREIFNNRLSAEFQTAQETLKKHNSNLEKDLVRIRTARDELLSKVAVLEAQKSKSDMLEDLEKMLALQQEQLKALSEHKPEPARDAVMKELQDLEKAFKELSQYSNKKYSEYVNQESLMSKLTVEKTKADQKYFAAMRSKDSILIENKNLSKNLSKSNELIQQLKDIEKSLQAKIENLNKQLHISRINEKRLLDSNKTTSLKIMDLTSQLSKANKSSTLVQQECNKLIEEKAKMESKLNDLEIETKNLATKLTYQENKSKKLHKTLVSNGGDNGALAEELENFRTVVYCSLCSKNWKDTVIKTCGHVFCADCCKERLAARMRKCPTCNKGFSSNDLLVVHL
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1, RING-type E3 ubiquitin transferase BRE1.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.