PharMolix/UniProtQA huggingface dataset:
Protein: TRAJ9_ECOLX
Sequence: MCAMDRRERALISQLHFTHSLGEAISFLKYPVCVRFEDGSFIKENNCFEKLIRSSFNSCDEWFDSLKLECKLQLSRAEIESCSSIYGVNCNNDILLNNVLWSVIIESVITPCGYFFIWRFIWVANDNLSSFVVSKYSNELIVPSDEYVGIEPYLIGFSHHYSSAKMNITVSKSKKKTMKLFKRYGFSSRDLWLDEMIRTEKILPLYAKVKEILGR
What is the function of this protein?
This protein is essential for positively regulating the expression of transfer genes that are involved in the conjugal transfer of DNA between bacterial cells.
What are the official names of this protein?
Protein TraJ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZKSC8_PANTR
Sequence: MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHENNPLGQEVFRLRFRQLCYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVPQESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQKDLSRDNRPEDFRNVFSLGGETRSENRELASKQVISTGIHPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein with KRAB and SCAN domains 8, Zinc finger protein 192.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDXT_DICTD
Sequence: MRIGILAIQGSVVEHEKMLKRLEVETVLVKKPEHLDIINGIILPGGESTTFFTLLENRLLFDVLREKLANGLPAMGTCAGLILLANRIENHPDQKTLKVLDITVSRNAYGRQRESFSTYIKIPILGEKEFECVFIRAPQIVEIGKNVKVHATFENKPIFVEEGNILGLTFHPELTDDLRIHEYFLKRCSE
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: MUTT4_MYCTU
Sequence: MSDGEQAKSRRRRGRRRGRRAAATAENHMDAQPAGDATPTPATAKRSRSRSPRRGSTRMRTVHETSAGGLVIDGIDGPRDAQVAALIGRVDRRGRLLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWFVTDGRRVHKTVHHYLMRFLGGELSDEDLEVAEVAWVPIRELPSRLAYADERRLAEVADELIDKLQSDGPAALPPLPPSSPRRRPQTHSRARHADDSAPGQHNGPGPGP
What is the function of this protein?
May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool (By similarity).  In vitro has dATPase rather than 8-oxo-dGTPase activity.
What are the official names of this protein?
Putative mutator protein MutT4.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: PNMA1_BOVIN
Sequence: MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVHYRVLGRMFWREENAKAALLELTGTVDYAAIPREMPGKGGVWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFENSSPAPGPDMPAEMLNYILDNVIKPLIESIWYKKLTLFSGRDIPGPGEETFEPWLEHANEVIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNPDITTAECLKALEQVFGSVESSRDVQVRFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKENVNQARLEQVIAGANHSGAIRRQLWLTGAAEGPAPNLFQLLVQIREEEAKEEEAAAEAALLQLGLEGHF
What are the official names of this protein?
Paraneoplastic antigen Ma1 homolog.
What is the protein family that this protein belongs to?
Belongs to the PNMA family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL28_DESVH
Sequence: MGKQCEVCGKKPQVGHHVSHSNIKTKRRFEPNLQSVRHQLPSGEVKTVTVCTRCLRSGAVTKPVVRKSA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: LDHD_LACHE
Sequence: MTKVFAYAIRKDEEPFLNEWKEAHKDIDVDYTDKLLTPETAKLAKGADGVVVYQQLDYTADTLQALADAGVTKMSLRNVGVDNIDMDKAKELGFQITNVPVYSPNAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAPTIGREVRDQVVGVVGTGHIGQVFMRIMEGFGAKVIAYDIFKNPELEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDKSIAEMKDGVVIVNCSRGRLVDTDAVIRGLDSGKIFGFVMDTYEDEVGVFNKDWEGKEFPDKRLADLIDRPNVLVTPHTAFYTTHAVRNMVVKAFNNNLKLINGEKPDSPVALNKNKF
What are the official names of this protein?
D-lactate dehydrogenase, D-LDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: MDH_SALRD
Sequence: MKVTVIGAGNVGATVAECVARQDVAKEVVMVDIKDGMPQGKALDMRESSPIHGFDTRVTGTNDYGPTEDSDVCIITAGLPRSPGMSRDDLLAKNTEIVGGVTEQFVEGSPDSTIIVVANPLDVMTYVAYEASGFPTNRVMGMAGVLDTGRFRSFIAEELDVSVRDVQALLMGGHGDTMVPLPRYTTVGGIPVPQLIDDARIEEIVERTKGAGGEIVDLMGTSAWYAPGAAAAEMTEAILKDNKRILPCAAYCDGEYGLDDLFIGVPVKLGAGGVEEVIEVDLDADEKAQLKTSAGHVHSNLDDLQRLRDEGKIG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: RL35_BEII9
Sequence: MPKLKTKSGAKKRFKITATGKVIYAQSGKRHGMIKRTNKQIRNLRGTNVMFKSDGDKIIRFFLPNG
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y1331_AERS4
Sequence: MPRPKIARQICGRPANSCFKPNGRPMHQLEQVALAADEFEALRLVDLEGMQQQEAAVVMGVSRQTLANILKKARYKVVDCLSQGKALMMQASDPDTSGDIPL
What are the official names of this protein?
UPF0251 protein ASA_1331.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: APT_LACP3
Sequence: MTINFKDYIASVQDYPEPGIIFRDISPLMADGKAYAAATDEIAAYAQDKGVEMIVGPEARGFIVGCPVAYKLGIGFAPARKKGKLPRPTVKASYDLEYGEATLYLHKDAIKPGQRVLVCDDLLATGGTIAATIRLVEQLGGIVVGTAFLIELSDLHGRDKIKDYDMFTLMSYTGA
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_FORLA
Sequence: MASLRKTHPLIKIANDALVDLPAPSNISVWWNFGSLLGLCLITQILTGLFLAMHYTSDISTAFSSVAHICRDVNYGWLIRNIHANGASFFFICLYLHIARGLYYGSYLYKETWNIGVVLFLLVMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVGDMLVQWIWGGFSVDNATLTRFFAFHFLFPFIVAAVTILHLLFLHETGSNNPAGLNSDADKISFHPYFSYKDLLGFVVMLLGLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILVLMVVPVLHTSKQRGLTFRPATQFLFWTLVADMIILTWIGGMPVEHPYIIIGQIASILYFALFLILIPLAGWLENKALEWV
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPG_GEOSW
Sequence: MASLRDIKKRINATKKTSQITKAMEMVSASKLNRAEMNAKSFVPYMDKMQEVVANIALGAGNATHPMLVTRPVKKTGYLVITSDRGLAGAYNSNVLRTVYQTIQQRHQSPDEYAIIVIGRVGLSFFKKRNFPVILNITGLPDQPSFADIKEIANKAVGLFADGTFDELYMYYNHYVSAIQQEVTERKLLPLTDLVDNKQRTTYEFEPSQEEILDVLLPQYAESLIYGALLDAKASEHAARMTAMKNATDNAHELIRTLTLSYNRARQAAITQEITEIVAGANALQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: L2HDH_BOVIN
Sequence: MVPALRYLGSVCGRARGIFPGGFSAAHTPASGKSRLLCQGGRRASTSSFDIVIIGGGIVGLASARALILRHPALSIGVLEKEKNLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALIYEYCNQKGISYKQCGKLIVAVEQEEIPRLQALYERGLQNGVQGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVDYRQVAFSFAKDFQEAGGSVLTNFEVEDIEMARESPSRSKDGMKYPIVIRNTKGEEVRCQYVVTCAGLYSDRISELSGCNPNPRIVPFRGDYLVLKPEKRYLVKGNIYPVPDSRFPFLGVHFTPRMDGNIWLGPNAILAFKREGYRPFDFSARDIMDIIIKSGLIKLVFQNFSYGVNEMYKACFLSATVKHLQKFIPEITISDVLRGPAGVRAQALDRDGNLIEDFVFDGGVGDIGNRILHVRNAPSPAATSSLAISGMIADEVQQRFKL
What are the official names of this protein?
L-2-hydroxyglutarate dehydrogenase, mitochondrial, Duranin.
What is the protein family that this protein belongs to?
Belongs to the L2HGDH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YEAE_ECOLI
Sequence: MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
What are the official names of this protein?
Uncharacterized protein YeaE.
Protein: FLPA_SULIY
Sequence: MSEVVTVKQTNMENIYECEFNDGSFRLCTRNLVSGFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNARFFLKVNGYMLLVIKARSIDVTKDPKEIYKAEVEKLENSNFETIQIINLDPYDKDHAIVLSRYKG
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: TSN9_MOUSE
Sequence: MARGCLCCLKYTMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFIVLLIILLAELILIILFFVYMDKVNENAKQDLKEGLLLYNTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNSTTPLWRTGCYEKVKLWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQHIHRTGKKYDA
What are the official names of this protein?
Tetraspanin-9, Tspan-9, Tetraspan NET-5.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface.
Protein: SYP_METS5
Sequence: MKISREKWSSNFSEWFDWVISQAEIYDYGRYPVKGSGVWMPYGFKIRQNVTTLIRKLLDETGHEEVLFPLLIPETLLKKEAEHIKGFEKEVFWVTHGGEDELEERFALRPTSEVAITLMESLWIKGYSQLPRKFYQIVSVFRYETKATRPMIRVRELSTFKEAHTVHETFEDAARQVDEAVEIYSKFFDILGIPYLISRRPEWDKFAGAEYTIALDTIMPDGRALQIGTAHHLGQHFTKAMDYKVQRADGSHVHPHQTSYGISDRVIATVISINGDDHGPILPPVVAPIEGVIIPIPGKSEEDTEKINKYAMEVESVLKNSGIRVALDASEDKTPGEKYYIWELKGVPIRIEIGPRELNSGTAFLKRRDTLEGKSVKREELVKEFRNLEDQISADLRKRAWEQFKERVKRFQSLDEAKKFLENRGGIAEVPWCGQDSCGLKIEEQVQARVLGTPLKPEPSGNCVVCGKPSTNILRIAKTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_XANC5
Sequence: MNAAPTVLQQQAQSLSEAVTQPIPGSRKIFVQGSRADLQVPMREIALTRTPTLFGGEENPPLSVYDTSGPYTDPRVAIDLAAGLAPLRAQWIAERGDTVALDGLSSSFGRGREHDVRLDAVRFPARRLPRVARQGANVTQMHYARRGIITPEMEYVAIRENQRLEAVTDASLRRQHPGQAFGASIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVDGRAEALTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAQRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICQIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGAQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDQTLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYAAEHGMSEAQALSTGMQEKSAQFVAQGAQVYRAT
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PYRF_STAA1
Sequence: MKDLPIIALDFESKEKVNQFLDLFDESLFVKVGMELFYQEGPQLINEIKERGHDVFLDLKLHDIPNTVGKAMEGLAKLNVDLVNVHAAGGVKMMSEAIKGLRKHNQHTKIIAVTQLTSTTEDMLRHEQNIQTSIEEAVLNYAKLANAAGLDGVVCSPLESRMLTEKLGTSFLKVTPGIRPKGASQDDQHRITTPEEARQLGSTHIVVGRPITQSDNPVESYHKIKESWLV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: MNMA_RALSO
Sequence: MSGKRVVVGMSGGVDSSVTAWLLKQQGYEVIGLFMKNWEDDDDSEYCSTRQDWIDVVSVADLIGVDVEAVNFAAEYKDRVFADFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMALGADTIATGHYARVREAGGRFELLKAFDHTKDQSYFLHRLNQAQLSRTLFPLGEMPKTRVREIAAEIGLPNARKKDSTGICFIGERPFRDFLNRYLPTKPGPIRTPDGKTIGQHIGLAFYTLGQRKGIGIGGSRDGNGDAWYVARKDMAANTLYVAQGHDHPWLLAHTVHADDLSWVAGHPPAEGTQLAAKTRYRQADAPCAVTRATGDALTLTFQQAQWAVTPGQSAVLYDGDICLGGGIIASTEAASLEQAVA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBE_HELAN
Sequence: MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTENRQGIPLITGRFDSLEQLDEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FKB12_VICFA
Sequence: MGVEKQIIRAGTGPNPSRGQNVTVHCTGYGKNGDLSQKFWSTKDPGQNPFTFKIGQGSVIKGWDEGVLGMQLGEVARLRCSPDYAYGAGGFPAWGIQPNSVLEFEIEVLRAQ
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP12, PPIase FKBP12, 12 kDa FK506-binding protein, 12 kDa FKBP, FK506-binding protein 12, VfFKBP12, FKBP-12, Immunophilin FKBP12, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPPA_METAC
Sequence: MRLNLEHFDIKIGQHKVMFNVADAKELGVNPGDRVRIRGHQSISAIVDTTEDMVPPGTLGVFSEVYEHFEDWDKPVEVVPALRSKSSGVIKKMLDKKSVLQDEIKLLVNDIVEENLSDVELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPVMDKHSIGGVPGNKISLLVVPIVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSEEVKEIAEKVGGALVWGGATNIAPADDKLIRVEYPLSIDPYYQMLASIMAKKGAIGAENVVMDIPIGPSTKVPTVQEGQKLARDLINLGHRLGMNVECAITYGSSPIGRRVGPCLEVREAMKVLESMEGPNSLIEKSAALAGILLEMGGAAPRDRGKELALETLRNGKALEKMKQIIEAQGGDPNIKSDDIQVGQYTADIYASTDGYVIEFDNKWIIEIARLAGAPNDKGAGVAIHKKMGEQVKKGDAILTIYAEKEFKLDLALTTAQRTNPIIVEGMLLKRIPGIYGFQ
What is the function of this protein?
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P).  Exhibits phosphorylase activity toward CMP and UMP in addition to AMP.  Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
What are the official names of this protein?
AMP phosphorylase, AMPpase, Nucleoside monophosphate phosphorylase, NMP phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: TILS_RICCN
Sequence: MLYEKFEYNINNLIGNFGLSKISIAVSGGSDSVALLYLANIWAEKNNIELFVISVDHNLREQSKQETHYIQNISNSLNRKHYSLSFDHQNNFSNLQERAREGRYDLMTNLCLELDILVLLTAHHEDDYVENFCLRLERNSGIFGLSSSNINWYNNIQIIRPLYNIPKSELVEYLVRHNIKWFEDESNSSDKYRRNVIRQKLAKGADYIRHFSKPVYREEFKGDTERSTAAYTLVREDASTGTASKLSLEAKCGKMSKAAIISQQLKTNKLIENEFKPELISAIAEAVKIFEYGFAFLDLVKFDKFSNEVKVQIINFLLIIISGQSRAARFYSVEPILKLITQDVNFKNTLHGCIIKRIQNELLIYREFGKKLPESKILLDKSVIWDNRFCITKNQETPNCFVTHLSLKDYKIIKKQLDLEPLKNLSCKNHNAVLLTLPIIKILEKVIAIPHISYYDNDMWNFEVSFSPNFVSRFTHFC
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_PERMH
Sequence: MEWKDTLNLPKTAFPMKGNLPNKEPEIIKKWEEIDLYKRLREERKGKEKYILHDGPPYANGNIHLGHALNKILKDILVKYESMKGKDAPFVPGWDCHGLPIEQQVEKLLKKEKKRKEDLSKSEFRKLCREYALKYVNIQREEFKRLGIIGNWEKPYLTMRPSYQAQEIRELGKIFRKGIAYRGKKPVYWCIYDKTAEAEAEVEYKEKKDPSIYVAFELVESPFDIKEKVYAVIWTTTPWTLPANLGIMVNPDFDYLFLRSEDKVYIVAKDLLESFSEKTGIEGEVIKEVKGRELEFLEYRHPFIDRVSKIYLSEFVELGTGTGLVHMAPGHGQEDYIIGQRYGVEAFAPVDDEGRFTDEAPEFIQGLRVFEANERIVEKLRENGVLLHHETVKHSYPHCWRCKNPVIFRATPQWFISMDGITEKGETLRGEALKEIERVKWIPHWGENRIKSMIENRPDWCISRQRSWGVPIAVFYCKRCGNIIDDEKVFEHIADLVEKDEFGADIWFEREAEELLPEGYRCPKCDGEEFKKEEDILDVWFDSGVSHASVLKSGFWDELKWPADMYLEGSDQHRGWFQSSLLEGVASYGRAPYDAVLTHGFILDEKGNKMSKSLGNVIPPEKIIKMYGADILRLWVVSEDYTEDIKIGMNLLKSIADDYRKIRNTFRYFLGNLYDFDANKDRVPYENLLEIDRWMLSKLQRLIDRSHSAYSNYRFHKIYHEIKRFVIVDLSAVYLDILKDRLYVYAPDSLERRSAQTVLYELLDSLTKLLAPILSFTTEEIWGYVREINPSVKESIHLEEMPVVNQDYIDPELEETYEKLMKVRDDILKALEEARRSDIIRHPYEAKVVLSLPDEYRSVVEKRIDWIKFFFTVSQVELSDQAEGDVIIGGEKVEGGKIAVKKASGEKCPRCWIYDESVGKDGQPVCDRCMEQLERMEIKISDIEEAK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU133_CAEEL
Sequence: MSGRDLELTLDRVSSIEYPALVKEAFLNNWHASAHRSEVTSNCASLNDRYCWVLSRNQIFIWERAKSSHRAIIPTQLPLPTSGLPRSVKCVVVYDGVHRGANKTPCPGILVVSPEGVLRHWTSIESQTYIEEVLDINNEVALRVELTDEPIDGKSASFLLTTTSGTVYFLNGKGQDSAKTGALECNKVAGREAHGFRRRLSSIMFGGESKESTSLITNSFQHQSKDLLVVTVSPDVLTVYNMYTPCELWSLKTKEFFQPKIASFFEADLKRTPLKVRARLIDAAVFRDGLMILIGGTHEESQSVHMFMVWMSANWQTEQPTGVVWSARVPMNEHRALFSKIDDSIYSNLTLCIPKNTAESKKADRTDGIIIINPYFAVSLYLPFDLAKPKKPESLYRHVSIPPRDQLLGYAICSQYVYIMMLESGVSTIRLLPRGFADSSIYTHEQVVVPSLSVGTDDWPILSELLSEMVASGLPKTPLYQSLHRAFELFAEKHMAESEEELKAIIKMPDQEIARIVSQFLYAIIDYSDAANKTDTELHAKRVLTSRIMLFLKHMGVYERIISSPLGISRGGILSLRVGGTMLGEVSERVAASTAIWTWKTSNETNSAVFDAIIEKVLRIPEVQDLGLKDKDALFGRCGLVHHIPVVAAQQLEKNVIGKTKSHRFEVFHAVCELLSGIKETIISWRNCRTKVAIPKFPIWWTLETFASCYRDVAEKIIEELKNGSSTDSERARLLMYILSIYDFYLSESDSQPDNDKVLQEMIALGKPADAMELAEKHKDFGTLVKNYLTTDVGTRQKTFERYKKMFEKDDFEMYLCDYLKEHGRNDVLLQQGGSRVDAYLDNFKELRYSREIANKQFGKAALTLMSLADAETKSFSKFVEFLTRAYYCACSSIDGTDVSEVLDFYKRRYPEMKHRKRIPTEILKICFGNDLDAMMSVEDMLEWNMAVQPNDEASVEGFARAFHLLADLLAVHPDSDELKKKIDKTWKALVDYDEWNRVRSKEDVEKKTIFGKFCNYLINSYPADKGDSFPIWMPISRRLIFPTDIDTVLDECIANTTGNHLSWIKGHLKWIGEQLCKQALLPKSAFFRPDMKQVGSISQAALEAFGPILQRREQRFIDQLNRDSMMET
What is the function of this protein?
Important for early nematode development.
What are the official names of this protein?
Nuclear pore complex protein 15, Nucleoporin npp-15.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin Nup133 family.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus, nuclear pore complex. Note=Recruited early during nuclear envelope assembly after mitosis.
Protein: NHL12_ARATH
Sequence: MTTKDCGNHGGGGGGGTASRICGVIIGFIIIVLITIFLVWIILQPTKPRFILQDATVYAFNLSQPNLLTSNFQITIASRNRNSRIGIYYDRLHVYATYRNQQITLRTAIPPTYQGHKEDNVWSPFVYGNSVPIAPFNAVALGDEQNRGFVTLIIRADGRVRWKVGTLITGKYHLHVRCQAFINLADKAAGVHVGENAVKYMLINKCSVNV
What is the function of this protein?
May play a role in plant immunity.
What are the official names of this protein?
NDR1/HIN1-like protein 12.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SYCY2_MACFA
Sequence: MGLLLLVLILTPLLAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYQWDPNLKGLMTPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGKAPICVTAKRKNGTNVGTLPSTVCNVTFTVDPNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSTQFCQGRPSSCRTRNFWFRPADYNQCLQIPNLSSPAEWVLLDQTRNSLFWENKTKGANQSQTPCIQVLAGMTIATSYLGISPVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPTNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSQLPRARRAIHFIPLLAGLGILAGTGTGIAGITKASFTYSQLSKEIAKNIDTMAKTLTTVQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNQASSLRERATQGWLNWEGTWKWFSWVLPFIGPLVSLLLLLLFGPCLLNLITQFVSSRLQAIKLQTNGAGCRPRNIQESPF
What is the function of this protein?
Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.  Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).
What are the official names of this protein?
Syncytin-2, ERV-FRD provirus ancestral Env polyprotein, Envelope polyprotein.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
What are the subcellular locations of this protein?
Virion. SUBCELLULAR LOCATION: [Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass membrane protein.