PharMolix/UniProtQA huggingface dataset:
Protein: PSTB_BRADU
Sequence: MSELSVSMSAAGGLPQAPLLPEAPAKVTVRNLNFYYGEHHALKNINLTLGTNRVTAFIGPSGCGKSTLLRIFNRMYDLYPGQRATGQLMLDQTNILDGKLDLNLLRARVGMVFQKPTPFPMTIYENIAFGIRLYEKISKSEMDDRVEKALRGGALWNEVKDKLNASGLSLSGGQQQRLCIARTVAVRPEVILFDEPCSALDPISTAKVEELIQELSENYTIAIVTHNMQQAARVSDKTAFMYLGELIEFDDTSKIFTSPSDRRTQDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COAD_BRUME
Sequence: MTIAIYAGSFDPVTNGHIDVLKGALRLADQVIVAIGMHPGKKPLFSFDERVALIEASAKAVLHKDAARVSVIAFDGLVIDAARKHGAQLMVRGLRDGTDLDYEMQMAGMNGTMAPELQTVFLPADPAVRTITATLVRQIASMGGDIKPFVPVAVAAALNTKFKS
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNA2_MAIZE
Sequence: MALLSDLINLDLSGRTGKIIAEYIWVGGSGMDVRSKARTLSGPVDDPSKLPKWNFDGSSTGQAPGDDSEVILCPRAIFRDPFRKGQNILVMCDCYEPNGEPIPSNKRHGAAKIFSHPDVKAEEPWFGIEQEYTLLQKDTKWPLGWPLAYPGPQGPYYCAAGADKSYGRDIVDCAYKACLYAGIDISGINGEVMPGQWEFQVAPAVGVSAGDQLWVARYILERITEIAGVVVSFDPKPIPGDWNGAGAHTNYSTKSMRSDGGYEVIKKAIGKLGLRHREHIAAYGDGNERPLTGRHETADINTFVWGVPNRGASVRVGRDTEKEGKGYFEDRRPASNMDPYVVTCLIAETTMLWEPSHSNGDGKGAAAP
What is the function of this protein?
Plays a role in the flow of nitrogen into nitrogenous organic compounds.
What are the official names of this protein?
Glutamine synthetase root isozyme 2, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35A_YEAST
Sequence: MAGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSLPKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLRAKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L35-A, Large ribosomal subunit protein uL29-A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: GHRB_YERPP
Sequence: MKPSIVLYKSIPTDLHQRLAQHFTVNSFDGLTPDNQPELLAALQQAEGLIGSGGKIDQDFLQLAPNLRAASTISVGYDNFDVEALSQRGIALMHTPTVLTETVADTMMALMLSTARRVVELAERVKAGEWQESIGDDWFGVDVHHKTIGILGMGRIGMALAQRAHFGFSMPVLYTSRRPHEAAEQRFGARHCSLDTLLAEADFLCITLPMTEQTYHMIGREQLAKMKSSAILINAGRGPVVDEQALIAALQDGTIHAAGLDVFEQEPLPVDSPLLTLRNVVAVPHIGSATHETRYNMAACAVDNLINALTGTVKENCVNPQVLITH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITT_ECO57
Sequence: MSLAKDNIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDAKELADPAFNAQKQALKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEVINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVGWPILAMWN
What is the function of this protein?
Responsible for the uptake of citrate in exchange to the efflux of succinate.  Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates (By similarity).
What are the official names of this protein?
Citrate/succinate antiporter, Citrate carrier, Citrate transporter.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_RUTMC
Sequence: MAKTSMKKMLEAGVHFGHRSRFWSPKMGRFIYGTRNGVHIINLEKTLPLFNDALNFASKITAVGRSILFVGTKRAASNIIKQEAMRCGMPYVNHRWLGGMMTNYKTIKVSIKRLKDLEFLAEENFNQFGKKEALMMTREMEKLERSLGGIKDLNDIPDVIFVIDIGVEKNAVAEAKKLHLPIIGIVDTNHSPEGIDYVIPGNDDSIRAIGYYAREIANAILEAKAATSTSIEKKVSVKKLETKKPGSKKTPIEQVPAKEEIIKTSIKEDKPETLNKIALNTMKKADLIAYAETQGVTINSTDTKAQTIEKLA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RSMJ_RHOPS
Sequence: MSAISRSALAVDFVGGAVGYKLRSGAARSHALLKATGVSANRPLHVIDATAGLGRDSFLLASMGATVTLIERSPQVHALLAQGLEAARAESDEIAAIVARMTLIHGDARALLPTLQADVVTVDPMHPARTKTALVKQEMRLLREMVGADPDVADLMQAALVARCGRVVLKWPLRAEPLAGIRKPSYQIAGKTVRYDVFVNPRAPAEEALPRADDLALFRF
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1325_THEP3
Sequence: MSIKLINIGFGNIISANRLVAIVSPESAPIKRIIQEAKNRGMLIDATYGRRTRAVIITDSDHIILSAVQPETVANRLNSNKEILEDTLEEDEEEEEE
What are the official names of this protein?
Putative regulatory protein Teth39_1325.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: TA17_TREPA
Sequence: MKGSVRALCAFLGVGALGSALCVSCTTVCPHAGKAKAEKVECALKGGIFRGTLPAADCPGIDTTVTFNADGTAQKVELALEKKSAPSPLTYRGTWMVREDGIVELSLVSSEQSKAPHEKELYELIDSNSVRYMGAPGAGKPSKEMAPFYVLKKTKK
What are the official names of this protein?
17 kDa lipoprotein.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SLRL2_ORYSJ
Sequence: MAQFGGFGGWSAMDVAAAAAAALGNVSGAVYHADPAAAVYASLVPGMAVVPGRAPPSAVQIEAARRWKELEKMALRSVNLMVTCAGAIQAGDYAAAAGSLSDAREIFAKMPTTRTGIGRVLTHFADALAERLFPAFPQSAPPPPPPRGEQRELFRGFYEAGPYLKFAHLAANQAILEAFEGCNSVHVIDFALTDGIQWPSLIQALAVRPGGPPFLRITGIGPHAAGNRDELRDVGLRLAEFARSCSVPFAFRGIAADQLDGLRPWMFQVAPGEAVAINSVLQLHRLLVDQDAAAAASFPAPIDGVLDWVASMNPRVFTVVEQEADHNKSSLLERFTNSLFYYASMFDSLEAISRHGGGDGAGNPLAEAYLQGEIADIVSREGSSRVERHEQMPRWVERLRRGGMTQLPLGATGLWQAAMQLREFSGAGFGVQENGGFLTLTWHSQRLYSASAWRATAGKKMTMMASGAADAMEESQNSNTNGGGGGSSGGGHGALNQIMQ
What is the function of this protein?
Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway (PubMed:17521606).  Its repressive activity is weaker than that of SLR1 (PubMed:17521606).  Its overexpression prevents the GA signaling pathway and induces a dwarf phenotype in Arabidopsis thaliana plants (PubMed:17521606).
What are the official names of this protein?
Protein SLENDER RICE1-LIKE 2, OsSLRL2, Protein SLR1-LIKE 2.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GABR2_CAEEL
Sequence: MSRWLSLLLFAVQAVGGYEAGEELSCKRRHGGIPLPLGVFTVQKEGFPDALPAIRTALSHVHSRSCILQGYRLEMIVKDTHCKTSQGMKALFDLIASRPRPVAILGGQCTEVNEPIAMALKYWQIVQLSYAETHAKFASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQNDQPRYALPHEALTTRLEHGFGVKIVHTAGVNWEQIETVGGELDELKERDVRIILVDVDEEMAATVLCAGYHRGMYGDNYVWILPGYHSDKWLNQTHDNCTVEEMREAAKNHFSVEFALTRRDVDTKIVGNTRAGDVWNEITQLDPNNTWRGYLYDGLWTLAIALSHSMGDNAEFSHHKMMEAIDNSSFQGLTGKVKFANNERLGLVDIKQWSDGQYVPFAVYDGADDEFKIIDSTTKGWSPPLDSTITERRREHISSILFLAMSLLALIGIFLALIFLLINFRYRNHRFIKMSSPNLNNIIIAGSICTFASVIMLGLDTRIVSPDVFVWLCYTKTWTLCIGFTLSFGAMFSKTWRVHSIFTNIRMDRKAIKDSKLFIILGILLFIDICVLVTWAFVSPFSYTVTELPHIPEDNIVIIPEVEKCNSSHSGVFQAVLYAVKGVLMILGCFLAWETRHVNVPALNDSKYIGTSVYCCVVMSVLGLSTSVILQERVNEMFSLASFFVIFSTTLTLCLVFVPKVIELARNPVGNEPRAYRRGLMKSVVAKTSQPMSPQPRSDSSGDLIGKAESENKLRRRYLHQKSTQLWDLVEKLRAQGDTRFLQQEWCLSSASPSSQERETSLLLRQPSSSNNREETSLTAAGPNGERSSDWPWVDPDEPSTKL
What is the function of this protein?
Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity).  Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity).  Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity).  Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity).  Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity).  Along with gbb-1, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679).  As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679).  Regulates locomotory behavior in response to GABA release by GABAergic motor neurons (PubMed:18614679, PubMed:21613582).
What are the official names of this protein?
Gamma-aminobutyric acid type B receptor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SGF11_DROSI
Sequence: MSAANMPTTTGAQGSGNQVPTTSTTIVNHFRELIKEPKNLDEAANYLFQTLLDDAVVGIFNETHHLRKSGNLAALDGVPEDSTYRMCEMPNLDIFGISTAKKPMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGATSAHLHSSGNTGGTDDEDDVDWSSDKRRKKSNQNSRNNGSKKNNGKTF
What is the function of this protein?
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Binds independently on SAGA to promoters in an RNA-dependent manner.  Binds to mRNA and is essential for total mRNA export from the nucleus.  Required to counteract heterochromatin silencing.  Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe.  Required for expression of ecdysone-induced genes such as br/broad.
What are the official names of this protein?
SAGA-associated factor 11 homolog.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: PYRE_CHLPM
Sequence: METSAMLSIFKETQALLDGHFKLTSGRHSDSYFQCAKVLQHPEHLGTICSAIADHFRESGVDTVISPAIGGIVVGTEVGRQLGVKTIFAERKDGRMTIRRGFSLEKNERVLVVEDVITTGGSVAEVMALVEAAGAEVAGVGCVVDRSNGTVRLADSQFSVISLEVHSWPAESCPLCRNGVPIEAPGSRAASPSPSA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: Y2016_MYCBO
Sequence: MVTHELLVKAAGAVLTGLVGVSAYETLRKALGTAPIRRASVTVMEWGLRGTRRAEAAAESARLTVADVVAEARGRIGEEAPLPAGARVDE
What are the official names of this protein?
Uncharacterized protein Mb2016c.
Protein: POTA_HAEIN
Sequence: MENQLQNKPIIELRSIKKSYGSNTIINDFNLTINNGEFVTILGPSGCGKTTVLRLLAGLEELDSGSIILDGEDITNVPAEKRHINTVFQSYALFPHMTIFENVAFGLRMQKVPNEEIKPRVLEALRMVQLEEMADRKPTQLSGGQQQRIAIARAVVNKPKVLLLDESLSALDYKLRKQMQQELKMLQRQLGITFIFVTHDQEEAITMSDRIVLLRKGKIAQDGSPREIYEDPANLFVARFIGEINVFEATVIERKSEQVVLANVEGRICDIYTDMPVEKDQKLQVLLRPEDIVIEELDENEHSKAIIGHIIDRTYKGMTLESTVEFDHNGMRVLVSEFFNEDDPHMDHSIGQRVGITWHEGWEVVLNDEDNQ
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PDXS_METTH
Sequence: MLHGTEVLKKGFAKMTKGGVIMDVVNAEQAAIAEDSGAVAVMALEKVPADIRASGGVARMADPNKVQEIMDAVSIPVMAKVRIGHFVEAQVLEALGVDMIDESEVLTPADERFHIDKKKFTVPFVCGARNLGEALRRIDEGAAMIRTKGEPGTGNIVEAVRHMRIMMSEIREIQNKEEEELWEVSRKIEAPLELVRETAKLGKLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSDNPEGYARAIVEATAHYDDPEVIAEVSRGLGTAMRGLEISEIPEEGRMQDRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: OLES2_BRANA
Sequence: MATVERRVQVDPTDKRIHLQPQYEGDVGYGYGYGGRADYKSSGPSSNQIVALIVGVPVGGSLLALAGLTLAGSVIGLMLSVPLFLLFSPVIVPAAITIGLAVTAILASGLFGLTGLSSVSWVLNYLRGTSDTVPEQLDYAKRRMADAVGYAGQKGKEMGQYVQDKAHEAHDTSLTTETTEPGKTRRHT
What is the function of this protein?
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil.  Probably interacts with both lipid and phospholipid moieties of lipid bodies.  May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth (By similarity).
What are the official names of this protein?
Oleosin S2-2.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: EFG_TROWT
Sequence: MSQEVLEDLAKVRNIGIMAHIDAGKTTTTERILFYTGITHKIGEVHDGAAAMDWMAQEQERGITITSAATTCFWGGNQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSETVWRQADKYKVPRICFVNKMDKIGADFHFTVKTVVDRLGATPLVIQLPIGSESTFEGVIDLVEMRALTWRGDAKGDVKMGAEYAVEPIPEDLKQQADEFRQKLIETVAENDEALLEKFFSGEEITVAELKSAIRRLTVSGSLYPILCGSSFKNRGVQPMLDAVVDYLPSPLDVPPVTGVDADNPQERLADVSQPFSALAFKVAVHPFFGRLTYIRVYSGTLPAGSQIVNSTKSRKERFGKVFQMHSNKENPVPKMSAGHIYAVIGLKYTTTGDTLCDQDNPIILESMTFPDPVIEVAIEPKTKADQEKLSLAIQRLAEEDPTFKTEQNPETGQTVIKGMGELHLDILVDRMRREFNVEANVGTPQVAYRETIRRTVEKHEYTHKKQTGGAGQFARVIITLEPLEVTGEKTYDFVDTVTGGRIPKEYIPSVDAGIRDAMQVGVLAGYPTVGIKATLVDGAYHDVDSSEMAFRIAGSQAFKEASRRADPTLLEPIMSVEVRTPDEYMGDVIGDLNSRRGHIQSMQDSSGIKVIQARVPLSEMFGYIGDLRSKTSGRAVYSMTFDGYAEAPKSVTEEVVRKARGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUSD4_RAT
Sequence: MAAPLLGSPGLQVLSMSSRTGKLFTPSSRSFCSRATSSRPLNAQRLAEKLRAQKQEQKTKEMRVPTNPVQRRVQELVRFTQQLQRVHPNVLAKELSRRILHQDKDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIMEKEVAGQQQHHKMTLRPSYRMDNGKMVKVRASRDAHVAVTQYQVLSSTPSSALVELQPVTGIKHQLRVHLAFGLDCPILGDHKYSDWNRLAPQKLSAGTLKKLGLQQSKARYIPLHLHARQLILPALGSRTEELLLACKLPHFFARSLRRLGLDMPNEDQSRSHEARHVEAR
What is the function of this protein?
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates.  Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA).  This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome.  As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.  Acts on position 39 in mitochondrial tRNA(Phe).  Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions.  Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing.
What are the official names of this protein?
Pseudouridylate synthase RPUSD4, mitochondrial, RNA pseudouridylate synthase domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Mainly localizes to mitochondrion. Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Also found in nucleus and cytoplasm.
Protein: KAD2_KLULA
Sequence: MSQDLSHVPESIRMVLIGPPGAGKGTQAPNLTERFCACHLATGDMLRSQVAKQTPLGIEAKKIMDDGKLVSDEIMINMIKDELTNNQDCKKGFILDGFPRTIPQAEKLDEMLAQQGRPLEKAVELKIDDELLVSRITGRLVHPASGRSYHKVFNPPKTEMKDDITGEDLVQRSDDNVEALKKRLTSYHKQTEPIVDFYKKTGIWAGVDASQPPKTVWSDILKCLGKN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: MALT_SALPA
Sequence: MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALVTSPAGYGKTTLVSQWAAGKNELGWYSLDEGDNQQERFASYLIAAIQQATGGHCSTSEAMAQKRQYASLTSLFAQLFIELAQWHRPLYLVIDDYHLITNPVIHDAMRFFLRHQPENFTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFNHQEAKQFFDRRLSSPIEAAESSRMCDDVAGWATALQLIALSARQNHTSAHHSARRLAGINASHLSDYLVDEVLDNVDVSTRHFLLKSAILRSMNDALIVRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFSYHPLFGSFLRQRCQWELAAELPEIHRAAAESWMEQGFPSEAIHHALAAGDAQMLRDILLNHAWGLFNHSELALLEESLKALPWESLLENPRLVLLQAWLMQSQHRYSEVNTLLARAEQEIKGVMDGTLHAEFNALRAQVAINDGNPEEAERLAKLALDELPLAWFYSRIVATSVHGEVLHCKGDLSQSLSLMQQTEQMARHHDVWHYALWSLIQQSEIQFAQGFLQAAWETQERAFQLIKEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIAVLSTFQPQQQLQCLTLLVQCSLARGDLDNARSQLNRLENLLGNGRYHCDWISNADKVRVIYWQLTGDKKSAANWLRHTPKPAFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQSGRKNDAQRVLLDALQLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPEMEQHRAQRILREINQHHRHKFAHFDEGFVERLLNHPDVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELAVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.
Protein: ZHX3_MOUSE
Sequence: MASKRKSTTPCMIPVKTVVLPGASTEPQPVESLPEGPQQDLPSEAPDASSEAAPNPSSTDGSALANGHRSTLDGYVYCCKECEFRSQDVTHFIGHMNSEHTDFNKDPTFVCTGCSFLAKNPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPDSASSSVLAGESTTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPNQPGSEALPKPLAGEREVKEGDHTFINGAAPGSQASAKSTKPPPAANGPLIGTVPVLPAGIAQFLSLQQQPPVHAQHHTHQPLPTSKTLPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQATLPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTVAPINTVCSNSASAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGSRAMMPGEHGSVLIDSVPEVPFPLASKVPEVTCIPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLENSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKKVNTEETKKADGHMPKEEEEGAEQEGRDEELANELRVPGENGSPEMFLSHALAERKVSPIKINLKNLRVTEASGKSEFPGMGVCEPEEDGLNKLVEQPPSKVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLCEEDLQTLCDKTQMSAQQVKQWFAEKMGEETRAVADISSEDQGPRNGEPVAVHKVLGDAYSELSENSESWEPSAPEASSEPFDTSSPQSGRQLEAD
What is the function of this protein?
Acts as a transcriptional repressor.  Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation.  Is a regulator of podocyte gene expression during primary glomerula disease.  Binds to promoter DNA.
What are the official names of this protein?
Zinc fingers and homeoboxes protein 3, Triple homeobox protein 1, Zinc finger and homeodomain protein 3.
What is the protein family that this protein belongs to?
Belongs to the ZHX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OSCP1_MOUSE
Sequence: MSVRTLPLLFLNLGGEMLYVLDQRLRAQNIPGDKARKVLNDIISTMFNRKFMDELFKPQELYSKKALRTVYDRLAHASIMRLNQASMDKLYDLMTMAFKYQVLLCPRPKDVLLVTFNHLDAIKGFVQDSPTVIHQVDETFRQLSEVYGKLSEGEFQLIRQTLLNFFQDLHIRVSTFLKDKVQNSNGRFVLPVSGPVPWGTEVPGVIRVFSVKGKEVKKMKFRHGGDYVAAQKEGSFELYGDRVLKLGTNMYSASRPVETHMSATSKNAASRAQENIVPNPLAKEELNFLARLMGGMEIKKPSGPEPGFRLNLFTTDEEEEHAALSRPEELSYEVISIQATQDQQRNEELARIMGEFEITEQLEQNTSKGDDLLAMMDRL
What is the function of this protein?
May be involved in drug clearance in the placenta.
What are the official names of this protein?
Protein OSCP1.
What are the subcellular locations of this protein?
Basal cell membrane.