PharMolix/UniProtQA huggingface dataset:
Protein: RUTA_ECO57
Sequence: MQNAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPVLTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: RL25_PSYWF
Sequence: MSDILYTVNGITRTNDQQGKGASRRLRKQNLVPAIIYGGNEEPTAIAIKKNELWKLLENEAFFSNILTINLEGEEHLAVIKDLQRHPSKGFAMHADFQRIVKGQKINMQIPLHFTGREEAPGIKAGGILSTLVTDIEIVCLPSNLPEFLEVDVSNLEIGESLHLTDIKLPEGVVIFELDVDEPVDRTVVNMQAPTVEEVDTDAEEVDAADVPATEQGSEEDKGE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: GPBL1_PONAB
Sequence: MAQHDFVPAWLNFSTPQSAKSPTATFEKHGEHLPRGEGRFGVSRRRHNSSDGFFNNGPLRTAGDSWHQPSLFRHDSVDSGVSKGAYAGITGNPSGWHSSSRGHDGMSQRSGGGTGNHRHWNGSFHSRKGCAFQEKPPMEIREEKKEDKVEKLQFEEEDFPSLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPNAWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSENRDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGFGKNGFLQSRSSSLFSPWRSTCKAEFEDSDTETSSSETSDDDAWK
What is the function of this protein?
Possible transcription factor.
What are the official names of this protein?
Vasculin-like protein 1, GC-rich promoter-binding protein 1-like 1.
What is the protein family that this protein belongs to?
Belongs to the vasculin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRB_STAAS
Sequence: MTMVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_RICRO
Sequence: MISKINFVKMHGLGNDFVIVNKRDLSSSYDLSQLAKNMAERHTGIGCDQFILYEEHNDFYEMIIYNIDGSSAKLCGNATRCLAKLIYLDTGKQDITVMVGNKKLLCNVNDENNISVNVGSVSFNEAWMPSRDKVWEFAERYMIDLKETICVDIGNPHVVIFSKLEPQDQKIVGERLQAKELFADGVNVNFAEVKDNKIYLSVWERGVGLTLACGSGACGSFAAGLKHGFIHSPSTIVFKHGNLTMKEENGNIIMQGAATLVARGEYYCEQ
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAGL2_BOVIN
Sequence: MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINGLYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRYFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL
What are the official names of this protein?
Transgelin-2.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: TFP8L_DROPS
Sequence: MADNVFKSQDIGLRAQKKILSRMATKNIAKTFIDGTTASLLDNLYRLCKMHTGNKAKAEKLIKNIIKIVIKIGVLHRNNQFSDEELQRAENFKRKFQNTQLSIISFYEVDYTFDLAYLQKSIAESQVALKSIVQPHLTDKSLGRIDEVFDFFGDAVLLETAFKPDSPYREVMGKIVADINSAMETGDI
What are the official names of this protein?
Tumor necrosis factor alpha-induced protein 8-like protein, TNF alpha-induced protein 8-like protein.
What is the protein family that this protein belongs to?
Belongs to the TNFAIP8 family.
Protein: GTR8_RAT
Sequence: MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITAHFEGR
What is the function of this protein?
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10671487).  Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 8, Glucose transporter type 8, GLUT-8, Glucose transporter type X1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular (PubMed:10671487). May move between intracellular vesicles and the plasma membrane (PubMed:10671487). The dileucine internalization motif is critical for intracellular sequestration (PubMed:10671487).
Protein: RS10_ECOK1
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PSBT_PELHO
Sequence: MEALVYTFLLVSTLGILFFSIFFREPPKVPTQK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TRHO_ECOBW
Sequence: MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKATRDALYQLFTALNVFGRVYLAHEGINAQISVPASNVETFRAQLYAFDPALEGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPEEQRRRRAGRENGNKIFNKSRGRLNTTLCIPDPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.  May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: YTA1_PSEAJ
Sequence: LEQVLEYYLGECLRYVNRGLGLFPDCDGMYLQLSYFVQLGALTLQHGGDQPVKLLVDHGALLAGLRSLARVLADALLAGNPEAAVAFYQFYGPARLQPLQPLVTALGNSPAQSIEYVQEPVRVPTDCDATCAQARL
What are the official names of this protein?
Uncharacterized protein in tabA 5'region, ORF1.
Protein: RSMA_CHLPD
Sequence: MIKVEYKHTEIAVKKKLGQNFLTDRNITRKIVTESETNPDDTILEIGPGFGALTREISTITPRFTVVEKDPKLASFIRNEYPELTVIEGDFLTVDLKKIAGEKPLRVLGNIPYAITSPILFKLLENRHILLSATLMMQHEVALRITAKPRTKDYGILAVQMQAFCETKYLFRVGRKVFRPQPGVDSAVISMKPKVNDPVSDREGFSRFVRCAFHQRRKTLQNNLKKTYELDRVESSVLKQRAEELSIDEFFRLFEQIRPLMVSSADPES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYPC_CANAX
Sequence: MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM
What are the official names of this protein?
Proline--tRNA ligase, cytoplasmic, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_LISW6
Sequence: MKLHELKPSEGSRKERNRVGRGTGSGNGKTSGRGHKGQKARSGGGVRLGFEGGQLPLFRRIPKRGFTNINRKEFAIVNLDVLNRFEDGTEVTPELLIESGIIRNEKSGIKILSDGNIEKKLTVKANKFSAAAKEAIEAAGGKTEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ZAPD_BURM1
Sequence: MILYEYPFNERIRTLLRLEDLFERFAFFLAQEDPREHHVALTTLFEIAEVTGRADLKSDLMKELERQRQTLAPFRGNPGIEQNALEAVLGEIEQTLANLAQMQGKTGQHLVDNEWLASIRSRAVIPGGTCKFDLPSYYAWQQWPAEQRRQDIAKWIMPLLPLRDAATIVLRLARESGQASKVMAMQGSYQQMLSGRSYQLMQVRVPRELHVIPEASANKYMLWVRFTMQDGDVRPRAVDIDVPFQLTLCNL
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: UBIQH_DICDI
Sequence: MQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVECSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin-H.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YPFN_ECOHS
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y2675_BORA1
Sequence: MLFLLSPAKKLDYDTPVQAQTYTQPLFVEQAAALIKVLKTKSADEIAGLMSLSQALAELNVGRYAAWKKTFTLDNARQAVLAFNGDVYEGLEAPSLSASQLDWAQEHVVILSGLYGALRPLDLMQPYRLEMGTRLETPKGKNLYEYWGSTIAAYLNERQEGEGAPCIINLASEEYFKAVDLKTLKARVVQCVFQDWKGGAWKIISFHAKRARGLMVRYAIEHRAKTSEALQAFDREGYVFDASASSADKLVFRRRLD
What are the official names of this protein?
UPF0246 protein BAV2675.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MYCS_MOUSE
Sequence: MLSCTTSTMPGMICKNSDLEFDLLKPCFYPEEDDIYFGGHNSTPPGEDIWKKFELLPTPRLSPDSALAEHSLEPVNWATEMLLPEADLWSNPGEEEVFGQGGLRGCTSNPIILQDCMWSGFSNPGKPESVVSEKLPGGYRSLAVGAGTLAPGAAAAASSAGHERSGTAGVGRGKAAWLTELSHLDLECVDPAVVFFPANKREPMPVPTIPTSTGSAISLGDHQGLSSSLEDFLSNSGSVEEGGEEIYVVMLEETQFSKTVSRLPTAAHQENAALSPGCAQSSELILKRYDLIQEQHNYAAPPLPYVDREDARPQKKPRSHTSLALKCVFRPKAPRLGSRNNSDWENIERRRNHNRMERQRRDIMRSSFLNLRDLVPELVHNEKAAKVVILKKATEYIHTLQADESKLLVERKKLYERQQQLLQKIKQYALC
What is the function of this protein?
Has apoptosis-inducing activity.
What are the official names of this protein?
Protein S-Myc.
What are the subcellular locations of this protein?
Nucleus.
Protein: MC6ZA_XENLA
Sequence: MDLVDPSQSAAAAAGTQLVKDEVAEKCQKLFQDFLEEFQGSDGELKYQSDAEELIRPERNTLLVSFVDLEQFNQQLATTIQEEFYRVYPYLCRAVRAFARDHGNIPQNKEFYVAFQDLPTRHKIRELTTPRIGSLLRISAQVVRTHPVHPELVSGTFLCLDCQTLVRDVEQQFKYTQPSICRNPVCANRRRFMLDTNKSRFVDFQKVRIQETQAELPRGSIPRSVEVILRAEAVESCQAGDRCDFTGSLIVVPDISQLSTPGVRAETSSRVGGREGYEAEGVQGLRALGVRDLSYKLVFLACYVCPTNPRFGGKELHEEDMTAESIKNQMSVKEWEKVFEMSQDKNLYHNLCTSLFPTVHGNDEVKRGILLMLFGGVPKSTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDTKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRAKSLKQNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYTVDEVRRYLLFARQFKPKISKESADFIVEQYKRLRQRDGSGVTKSAWRITVRQLESMIRLSEGMARMHCSDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQDDEHEPEDETQEGTNGDAEVPNGVNGHVNGINGHSQESNAAAAKPSLRLNFAEYKRISNLLVQQLRKMEDEDETSQRRSELMNWYLKEIESEIDSEEELINRKQIIDKVIHRLVHYDQILIELTQTELKGTGDEVVAKEEDPYLVVNPNYILED
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.  May replace mmcm6 in the mcm2-7 complex.
What are the official names of this protein?
Zygotic DNA replication licensing factor mcm6-A, Zygotic minichromosome maintenance protein 6-A, zMCM6-A, zMCM6a.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: PNP_DEHMB
Sequence: MITANSFERTIGGRKLVIESGKLARLADAAITIRYADTELLVTLCSAKKPREGVDFLPLTIDYEERMYAAGKIPGGFIRREGRPSEQAILAGRLTDRPLRPLLPKEWRNDLQIIITVIASDKENDADIWGVVGASTVLAMSEIPYEGPVGASRIGYINGEFVLNPTFAQLESSQLDLVVVSTRKAVVMIEAGSKEIPEDIMINAIEFAHKANQELIDLQDEIRAKLGKEKLPVPVLEIPEEVKTAVAAFVKGRVNEALSHQDKTARENAVEGLQAELVAALSETFAEGDILAAYDKEIKKAIRSTILEKDIRVNGRGIKQLRQLDAETGLLPRVHGSALFTRGDTQVMAITTLGSLQESQQLDGLSAEDTKRFMLHYNFAPFSTGEVKRSGSPGRREIGHGALAERALVPILPTPEEFPYTIRLVADVVGSSGSTSMGSVCSSSLSLMDAGVPVKKAVAGISIGLITGENGTYCTITDIEGIEDNYGDMDFKVAGTRDGITAIQVDMKVKGISFDIIRDAIYQAKEARYNILDVMDKALAQPKTELSPYAPRMYKINIDPSKIGSVIGSGGKTIRSIIEQTNTTVDIENDGTVVIGAIDEASAKKAIKIIEDLTKDIEAGSIYTGKVTRIMTFGAFVEILPGKEGMVHISELADHRVEKVEDIVKVGDDITVKVIEIDNQGRVNLSHRVILNPNAVPISRNRDSQPRRPGPFRPSDRSNS
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_XANOP
Sequence: MTQLHFDNRLRQQLPGYQEEGARRREVRAAWSAVMPTPVAAPYLIAHSAEMAHVLGLDASEVASAAFAQVFGGNALYPGMQPWAVNYGGHQFGHWAGQLGDGRAISLGEAIGIDGGRYELQLKGAGPTPYSRGADGRAVLRSSIREFLCSESMHHLGVPTTRALSLVGTGDAVVRDMFYDGRPQREPGAIVCRVAPSFIRFGNFELPSARGDNALLRQWVDFTIARDFPELVGTAEALYADWFAQVCQRTAVMVAHWMRVGFVHGVMNTDNMSILGLTIDYGPYGWVDDYDPDWTPNTTDAQGRRYRFGTQPQVAYWNLGRLAQAVAPLFADQAPLQQGLNRFRDTYLACDRRDTAAKLGLAECRDEDLELIDALRALMRDAEMDMTLTFRGLIDLSPVHPDPAQLHDAFYDDHKRVASASQLQEWLQRYAARLQQDALSPDERRALMRLANPRYVLRNYLAQQAIDQAEQGDPSGVQELLEVMRRPYDDQSGRAAFAARRPEWARDRAGCSMLSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: D2HDH_PANAA
Sequence: MVTYSMIPQISQAPGLIQRVLTFLETLKAQGFTGDTATSYADRLSLSTDNSIYQLLPDAVLFPRSTADVALIARLAGEAAFSSLVFTPRGGGTGTNGQSLNQGIIVDMSRHMNRILEINTEQRWVRVEAGVVKDQLNAYLKPFGFFFSPELSTSNRATLGGMINTDASGQGSLVYGKTSDHVLGLRAVLLGGDILDTRPVPTALAENLAQTPTPEGRIYQQVLTRCREHRELILEKFPKLNRFLTGYDLRHVFSDDMQTFDLTRLLCGAEGTLAFISEARLDITPLPKVRRVVNIKYDAFDSALRNAPLMVEAQALSVETVDSKVLNLAREDIVWHSVRELITAIPDKEMLGLNIVEFAGDDAGQIDRQITQLCARLDTLMTQQQGGVIGYQLCDDLDGIERIYNMRKKAVGLLGNAKGRAKPIPFVEDTAVPPEHLADYIVEFRALLDSHGLSYGMFGHVDAGVLHVRPALDMCDPHQEMMMKQISDEVVALTARYGGLLWGEHGKGFRAQYSPAFFGETLFNELRRIKAAFDPHNRLNPGKICTPFDSEAAMMQVDATKRGSYDRQIPLQVRETWRGALECNGNGLCFNFDARSPMCPSMKITRNRIHSPKGRATLTREWLRLLAEQGADPVMLEKKLPESSLSLRALISRMRNTWYANKGEYDFSHEVKEAMSGCLACKACSTQCPIKIDVPAFRSRFLQLYHTRYLRPLSDHLVAGVESYAPLMAKAPGVFNFFLKQPWATSFSKTHIGMVDLPLLSSPTLKQQLSGHPAMNMTLEQLEALSETQRAQKVLVVQDPFTSFYEAKLVHDFIRLIEKLGYQPVLLPFSPNGKAQHVKGFLQRFARTASKTADFLNRVAKLGMPMVGIDPATVLCYRDEYHQMLGEARGDFNVLLVHEWLHQALQEREVQVTSGEAWYLFAHCTEVTALPGTPGQWQAIFSRFGAKLENINVGCCGMAGTYGHESQNLENSLGIYALSWHPQLQKLPRQRCLATGFSCRSQVKRVEGNGMRHPLQALLELI
What is the function of this protein?
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HGA) to 2-oxoglutarate.  Appears to be the only D2HGDH in P. ananatis, providing the way to recycle D-2-HGA produced during L-serine synthesis by SerA, by converting it back to 2-oxoglutarate.  Is involved in the utilization of D-2-HGA, that can support the growth of P. ananatis as a sole carbon source, although it barely serves as a good substrate.  The physiological molecule that functions as the primary electron acceptor during D-2-HGA oxidation by YdiJ in P. ananatis is unknown.  Shows strict substrate specificity towards D-2-HGA, since it has no detectable activity on L-2-hydroxyglutarate, L-malate, D-malate, L-lactate, D-lactate, L-tartrate, D-tartrate, L-glycerate, D-glycerate, glutarate, or pyruvate.
What are the official names of this protein?
D-2-hydroxyglutarate dehydrogenase, D2HGDH.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Protein: SSL5_STAAE
Sequence: MKMTAIAKASLALGILATGTITSLHQTVNASEHKAKYENVTKDIFDLRDYYSGASKELKNVTGYRYSKGGKHYLIFDKNRKFTRVQIFGKDIERFKARKNPGLDIFVVKEAENRNGTVFSYGGVTKKNQDAYYDYINAPRFQIKRDEGDGIATYGRVHYIYKEEISLKELDFKLRQYLIQNFDLYKKFPKDSKIKVIMKDGGYYTFELNKKLQTNRMSDVIDGRNIEKIEANIR
What is the function of this protein?
Secreted protein that plays a role in the inhibition of host innate immune system.  Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection.  Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity.  Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation.
What are the official names of this protein?
Staphylococcal superantigen-like 5.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
Protein: HBB_PHYMC
Sequence: VHLTGEEKSGLTALWAKVNVEEIGGEALGRLLVVYPWTQRFFEHFGDLSTADAVMKNPKVKKHGQKVLASFGEGLKHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVVVLARHFGKEFTPELQTAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1/2, Beta-1/2-globin, Hemoglobin beta-1/2 chain, Hemoglobin beta-I/II chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SMT_COPJA
Sequence: MCTSLSELKCPVFSTKRKLLLEFALRTSVDMAAQEGVNYLSGLGLSRLICLPMALRAAIELNVFEIISQAGPDAQLSPSDIVAKIPTKNPSAAISLDRILRMLGASSILSVSTTKSGRVYGLNEESRCLVASEDKVSVVPMLLFTSDKAVVESFYNIKDVVLEEGVIPFDRTHGMDFFQYAGKEERVNKSFNQAMGAGSTIAFDEVFKVYKGFDNLKELVDVGGGIGTSLSNIVAKHPHIRGINFELPHVIGDAPDYPGVEHVPGDMFEGVPNAQNILLKWVLHDWDDDRSIKILKNCWKALPENGTVIVIEFVLPQVLGNNAESFNALTPDLLMMALNPGGKERTTIEFDGLAKAAGFAETKFFPISQGLHVMEFHKINC
What is the function of this protein?
Produces a precursor of protoberberine alkaloids.
What are the official names of this protein?
(S)-scoulerine 9-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.