PharMolix/UniProtQA huggingface dataset:
Protein: CALJ_PENDC
Sequence: MSDFDALLANYTSKETPKVHGVICKCVDRHGICPTPHLAKRDLRLTLLGNEIYSKVAGYDSVLPGASPLREDVVLKVASATKLITSIALLQCIDKGLIDLDEPVTKVLPEFDQKQILTDVSGSDLVLEPSKTPITARHLLTHTSGLGYPFTHRLLRLRAEVRNRAGVSPSLRVTERYEMPLVFEPGTGWLYGCSLDWAGVIVSRLHGGISLEQYFVENIWQRLGLSEPFPCFNIARHPEYNARVMGGAIQTPEGRLQPKDHWAFDNPEDQDGGSGLSCTTKDYVAVLADLVSDSPKLLKPATIAEMFTPQLEAKSPGVQMLLGLRPAWDTVSGPIAENAINHGLGGVLCMDDVPEIDQPKGMLGWGGASNIVWWVNRELRVAGFFATQQAPFGNPSVTRLVNAWKKDFWAQFKTIDHA
What is the function of this protein?
Acyltransferase; part of the gene cluster that mediates the biosynthesis of calbistrin A and related compounds.  Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells.  It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure (PubMed:30598828).  The polyketide synthase calA is probably responsible for forming the decalin moiety.  Because calA lacks a designated enoylreductase (ER) domain, the required activity is provided by the trans-enoyl reductase calK (PubMed:30598828).  Following release from the PKS, calF then probably catalyzes the oxidation and the subsequent Diels Alder cycloisomerization that lead to the formation of the decalin moiety (Probable).  The decalin polyketide backbone includes two C-methyl groups, at C7 and C11 in backbone, of which the C7 position is probably methylated by the methyltransferase domain of calA.  A candidate for adding the methyl group at C11, if not done by CalA, is the cluster methyltransferase calH (Probable).  Several additional tailoring enzymes within the cluster could be involved in the modification of the decalin polyketide product.  Those include the 3 cytochrome P450 monooxygenases CalE, CalG and CalL, of which one might be responsible for the introduction of the extra hydroxyl group attached to the backbone of the decalin moiety, at position C9 in the backbone, that allows for attachment of the linear moiety (Probable).  One tailoring enzyme activity that is expected to be involved in biosynthesis of calbistrin is an acyltransferase for connecting the two polyketide synthase products, and which could be performed by the cluster acyltransferase calJ (Probable).  The enzyme responsible for the biosynthesis of the linear moiety, probably a second PKS, has not been identified yet (Probable).
What are the official names of this protein?
Acyltransferase calJ, Calbistrin biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: RLMI_ECOUT
Sequence: MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKANLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFTRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECAIYDRSDVAVRKKEGMELTQGPITGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSHEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y759_METJA
Sequence: MVIKKGEIMNEIISLVSLSVIFGAMLSGFATFRLTGMRLMPHFASLMIAFILTLASLFISNNIIGYLAIAFQVITPLTVCPTICNILKTQFQNTGIYSAHLALMGMMFILALGNVILF
What are the official names of this protein?
Uncharacterized protein MJ0759.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLCA1_MOUSE
Sequence: MESLKSPVFLLILHLLEGVLSESLIQLNNNGYEGIVIAIDHDVPEDEALIQHIKDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETFKNADVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKLTQYGPQDRTFVHEWAHFRWGVFNEYNNDEKFYLSKGKPQAVRCSAAITGKNQVRRCQGGSCITNGKCVIDRVTGLYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNHNQEAPNDQNQRCNLRSTWEVIQESEDFKQTTPMTAQPPAPTFSLLQIGQRIVCLVLDKSGSMLNDDRLNRMNQASRLFLLQTVEQGSWVGMVTFDSAAYVQSELKQLNSGADRDLLIKHLPTVSAGGTSICSGLRTAFTVIKKKYPTDGSEIVLLTDGEDNTISSCFDLVKQSGAIIHTVALGPAAAKELEQLSKMTGGLQTYSSDQVQNNGLVDAFAALSSGNAAIAQHSIQLESRGVNLQNNQWMNGSVIVDSSVGKDTLFLITWTTHPPTIFIWDPSGVEQNGFILDTTTKVAYLQVPGTAKVGFWKYSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSVKIWALGGVTSDRQRAAPPKNRAMYIDGWIEDGEVRMNPPRPETSYVQDKQLCFSRTSSGGSFVATNVPAAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASNYIIRMSTSIVDLRDHFNTSLQVNTTGLIPKEASSEEIFEFELGGNTFGNGTDIFIAIQAVDKSNLKSEISNIARVSVFIPAQEPPIPEDSTPPCPDISINSTIPGIHVLKIMWKWLGEMQVTLGLH
What is the function of this protein?
May be involved in mediating calcium-activated chloride conductance.  May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR.  May be involved in the regulation of mucus production and/or secretion by goblet cells.  Involved in the regulation of tissue inflammation in the innate immune response.  May play a role as a tumor suppressor.  Induces MUC5AC.
What are the official names of this protein?
Calcium-activated chloride channel regulator 1, Calcium-activated chloride channel family member 3, mCLCA3, Protein gob-5.
What is the protein family that this protein belongs to?
Belongs to the CLCR family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.
Protein: Y899_OCEIH
Sequence: MVSPNAGSKVSIQSYKHNGQLHRTWENSVILKGTESVVIGANDRTKVIESDGRSWITREPAICYFHSKYWFNIIGMLRNDGIYYYCNISSPFVYDGEALKYIDYDLDVKVFPDMTFQLLDEDEYEEHRNLMNYPQVIDRILHQQLEILIRWIRQGKGPFSPDFVDNWYEMYLTYH
What are the official names of this protein?
UPF0374 protein OB0899.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: PAT_ECO24
Sequence: MNRLPSSASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAGGLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVEEA
What is the function of this protein?
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline.  This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal.  Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Putrescine aminotransferase, PAT, PATase, Cadaverine transaminase, Diamine transaminase, Putrescine transaminase, Putrescine--2-oxoglutaric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
Protein: RABZ_DICDI
Sequence: MGCFHSREPTATGKTKKEEPTSAVKTNKEEKSSNYVSEPTTMEKIKKDDVYTIILIGDQATGKSSVLQRFKNNQFEVCHKPSPIIIDCFTKKIQIEGKKISLKCYDTAGQEKFRALSQSYYRCADGIMLFYDIANQKTFDNVGRWLEEVHRLAGPNVPILIIANKCDLNEKRVVNFNNAKKFADDKNIPIIEVSAKESLGVEEAFIKLASEINKTWKPLPDNETVTIGM
What are the official names of this protein?
Ras-related protein RabZ.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
Protein: RLMN_PHOPR
Sequence: MTTVKTNLLDLDRKGLRTYFAEELNEKAFRADQIMKWIYQFGCDDFDQMTNINKKLREKLKRVAEIRAPYVSQAQHSVDGTIKWAMRVGDQDVETVYIPDGDRATLCVSSQVGCALACTFCSTAQQGFNRNLRVSEIIGQVWRAAKEIGIEKDTGRRPITNVVMMGMGEPLLNMKNLIPALEIMLDDIGFGLSKRRVTVSTSGVVSGLDQMTGNIDVALAISLHAPTDELRSQIMPINDRFNIATFLESVSRYIEQSNANRGRVTVEYILLDHVNDDMEHARQLAVLLKDTPAKINLIPFNPYPGSPYRKPSNSRIDRFMKTLMEYDFTVTVRKTRGDDIDAACGQLVGDVIDRTKRTQVKQHDGEQIPVKTV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQOR_SALEP
Sequence: MAKILVLYYSMYGHIETMAHAVAEGAKKVDGAEVIIKRVPETMPPEIFAKAGGKTQNAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLGSVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: MINE_PSEPK
Sequence: MNLFDFFRGRQKQTSASVAKERLQIIVAHERGQRSEPDYLPALQKELLEVIRKYVNIGNDDVHIELENQGSCSILELNITLPDR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RS16_CUTAK
Sequence: MATKIRLKRLGKIRTPHYRVVVMDSRAKRDGRAIEEIGQYHPKADPSVIVIDSERVQYWLGVGAQPTEAVVALLKRTGDWQKFTGDTSPSGVKPQPERPNKDDLFNAALAEADEAPREAITKKSEGAAADEASESAAGDNSGEKAEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RPOA_STAAN
Sequence: MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RL25_STRAW
Sequence: MSEVKLAAEPRTEFGKGAARRIRRESKVPAVVYGHGAEPVHITLPGHELLLALRTPNVLLSLDIEGKAQLAIPKAVQRDAIKGFLEHVDLLLVRSGEKVNVEVYVHTEGDLAPGAYLLEHVLSTLTVEAEATHIPESVTVSIEGLEAGASILAKDIPLPSGTTLAIDEDAVVLQVLAAQAEEAAEEAAGTAEVGSEA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: MED19_NEUCR
Sequence: MSFHPQTPQSPSHFSPSSSDQSTSMSGSIVSTTTTLPTPAHSVNGSSLANDMSFTDIVMGENSPQKRKRTSDDVGDREQKKVHIEDRKLGIDDLHLDVGEKYLLCRSQHQPPRPHLSEDLFEMYGLADLAAEYARIKDGQKNALRKTYKGHIKKLGVQGHFDSVKTDEKDPERLEYLMGCPQEEWNAHFVRGKEITRGLSSDMKSKISRAVTMSRGAVPSTLWNNSVLGDIAASSMKAHLNQPPSARPTAPNTPLAYGGPAMQRVKPQTPGFQDNRPRRNIKKRGYGDSSFEGYGEGFEDDGGLETGYSTGEGDMASGLKRRKKAQPGTQSYAQARQQSSYGHHGVSGI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 19, Mediator complex subunit 19.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAP11_ARATH
Sequence: MALALSLSACSPPLRRTRRAGFRTSCSIFANPAQRAKRKLLELISEEDRGLRTQKDPKKRDEIVNAIESMTVIGRSSITTDDSLSATWRLLWTTEKEQLFIIEKAGLFGTTAGDVLQVIDVNKRILNNVITFPPDGVFFVRSDIDIASPQRVNFRFNSAVLRGKNWELPLPPFGKGWFENVYMDGEIRVAKDIRGDYLIVDRAPYNWTESFV
What are the official names of this protein?
Probable plastid-lipid-associated protein 11, chloroplastic, Fibrillin-9.
What is the protein family that this protein belongs to?
Belongs to the PAP/fibrillin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid.
Protein: AROB_RHOPB
Sequence: MTAPLNHSAPITVEVALGDRGYDIVIGRDVLRSLGTRIAALRPGARTAIVTDRNVATCWLAQTQAALDDVGIVSMPIVVEGGEGSKSYAGLQQVCEALIAAKIERNDLVIALGGGVVGDLAGFAASIVRRGLDFVQVPTSLLAQVDSSVGGKTGINSPHGKNLVGAFHQPVLVIADTAVLDTLSPRQFRAGYAEVAKYGALGDEAFFAWLEANHAEIVRGGSAREHAIATSCRAKAAIVARDERETGERALLNLGHTFGHALEAATGFSERLFHGEGVAVGMVLAAQFSAERGMLSNDAAARLSHHLAEVGLPTRLQDIAGFAQEGLADADALMALMAQDKKVKRGRLTFILLEAIGRAVIAHDVEPEPVRDFLARKLADKT
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPE_DICCH
Sequence: MSDQPVHTSELRPVLPFAFARAQQILLLQDESASAAEVVCVPETPALALLEVRRVAGVALTVSQVSPEEFERQLVMRYQRDSEEARRLMEDIGNDIDFYTLAEELPDSDDLLDGEDDAPIIRLINAMLTEAIKHKASDIHIETFERHLLIRFRIDGVLREILRPQRQLASLLVSRIKVMAKLDIAEKRVPQDGRMALRIGGRAIDVRVSTLPSNYGERVVLRLLDKNSVRLDLETLGMAEHHRRQLDTLIHRPHGIILVTGPTASGKSTTLYAALSPLNSAERNIMTVEDPIEYELEGIGQTQVNPKVDMTFARGLRAILRQDPDVVLVGEIRDGETAQIAVQASLTGHLVLSTLHTNSALGALSRLQDMGIEPFLLSTSLLGVLAQRLVRTLCPSCRQPYTIDHEQAEQTGLAAGTTLYHPGGCEKCNYSGYRGRTGIHELLLIDDTVRAAIHRGESELGIARMLGAKRVTIRQDGLDKVLAGITTWEEVVRVTKEE
What is the function of this protein?
ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
What are the official names of this protein?
Type II secretion system protein E, T2SS protein E, General secretion pathway protein E, Pectic enzymes secretion protein OutE, Type II traffic warden ATPase.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cell inner membrane. Note=Membrane association is not an intrinsic property but requires the OutL/GspL gene product.
Protein: Y1299_STAAW
Sequence: MALKHYKNSDSTVFNDAKALFDLNKNILLKGPTGSGKTKLAETLSEVVDTPMHQVNCSVDLDTESLLGFKTIKTNAEGQQEIVFVDGPVIKAMKEGHILYIDEINMAKPETLPVLNGVLDYRRQITNPYTGEVIKAVPGFNVIAAINEGYVGTLPMNEALKNRFVVIHVDYIDGDILKNVIKEQSLLQDDKQIEQIIKFNEDLRTMSKQGQISEEAASIRALLDLCDLITVMPVERAIKRTIIDKLEDEREQQAIYNAVELNF
What are the official names of this protein?
Uncharacterized protein MW1299.
What is the protein family that this protein belongs to?
Belongs to the CbbQ/NirQ/NorQ/GpvN family.
Protein: TRPB_SHIDS
Sequence: MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETDVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RS6_SHESW
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGVITEANGTIHRLEDWGRRQLAYPIQDLHKAHYVLMNVEAPAETIEELETAFRFNDAVLRNMVMRTKVAVTEASPMARARDERDSRRGPAGERSYDEAHAEEIGE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: YAI7_ENCCU
Sequence: MPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETEPPIISHCPPPHPGPTATPNLLPCPNPTSSFCQNTRDSPSLPPNVQTWSIFPKHPSKDVTAQVKSQSVSHRAPITYQPPRPTTTSNPRISQSYHMKSISSYLSFAHMNITHTTEQHAENQPHWKTILDIAPFVSITFPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYALLYTNWKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSLNEWDHAASFFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISVCSIVNVLLVFKEFNYYPYSAIISSISVLLQLLSEKHCLFKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAIYILDDHFHLLGKMKSILPSEPHQ
What are the official names of this protein?
UPF0328 protein ECU10_1870.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: INS_ELEMA
Sequence: FVNQHLCGSHLVEALYLVCGERGFFYTPKTGIVEQCCTGVCSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOCD_ACIBT
Sequence: MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQATFEEFPTVWVERARVQEVLMFLRKVERPYVMLFDLSAMDERLRQHRDGLPASDFTVFYHLLSLERNSDIRIKVALNENDLNLPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWEGHPLRKEYSARATEYTPYMQDKAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRIVLQLDGEEVKDCVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLYCGTAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWQKLVKELLDWMPKRLNEYYTAAFKNSVFIGRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFEVPVEYEGDAYARVLVHFREIEQSLKIIKQCLDNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKATMSYRTRIRTPTFTHLQQIPSVINGSLVSDLIIYLATIDVVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DXS_MAGMM
Sequence: MTTLLSTIDSPKALRQLNEAKLPQVAQEMRDHIIECVSQSGGHLGASLGVVELTIALHYVFNTPDDRLVWDVGHQSYGHKVLTGRRDQLASIRQRHGLSGFTKRSESPYDPFGTGHSSTSISAAMGMARAAKANGIQRKAVAVIGDGAMGAGMAFEALNHAGHDNHDLDLVVVLNDNEMSISPNVGALSSYLNRMLSGGAYNAFRDGTGKVLKTISRSMWDAAKKAEEHVKGLVMPGTLFEELGFTYFGPINGHDFDALLPTLRNVQKLGGPILLHVITKKGKGFPPAEEHPCTYHGVAPFDKDTGIIQSSSGGTSYTKVFAQELCALAEQNPHIHAITAAMREGTGLNLFEKRFPERFHDVGIAEQHAVTFAAGLATEGILPVVAIYSTFMQRAYDQLIHDVALQDLPVIFALDRAGLVGADGATHAGAYDLSYLRTVPGMTIMAPADENELRHMLHTAVALNKPVALRYPRGTALGLPPEPPHVLEIGRGRTLRKGEHAAILAVGQPVHPALEAAAILEQQGISVSVYDARFVKPLDQRLLQEVAMHGVVLVVEENAVQGGFGSAVLESLSNQGALDRGLKIRCMGIPDRYIPHGTQKELRGEIGLDAVGIATTLKELLG
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: BKDA_MYCTO
Sequence: MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD
What is the function of this protein?
Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).
What are the official names of this protein?
3-methyl-2-oxobutanoate dehydrogenase subunit alpha, Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha, BCKADH E1-alpha.
Protein: SEC11_YEAST
Sequence: MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:2644273, PubMed:7615509, PubMed:10206957, PubMed:11058593).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Secretory protein 11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: Y1210_VIBC3
Sequence: MAAVWREGDDLLLRLYIQPKASRDSIVGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVIEKGELGRHKQVRILQPSQIPAEITALIE
What are the official names of this protein?
UPF0235 protein VC0395_A0010/VC395_0502.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: TBP3_METMA
Sequence: MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSGKVVCTGSKSIGNAHAAIINLANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAIAFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITGGKCPEDCEEGLRIVKTEFDNLGLLY
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
What are the official names of this protein?
TATA-box-binding protein 3, Box A-binding protein 3, BAP 3, TATA sequence-binding protein 3, TBP 3, TATA-box factor 3.
What is the protein family that this protein belongs to?
Belongs to the TBP family.