PharMolix/UniProtQA huggingface dataset:
Protein: CTSRD_RAT
Sequence: MLMLMLAAVATVVRAQTVCRFRTVRTGKVFANPVTLEGDLLFYAFSNTVVVKNVCKTDIAVYLGQRVFITKNRFEASILPLTIPKSMEVKMPSITSAHFVSDAMILFVIDGKVYSYNFIEDIWRTVNGITEPVSHISGDPCCFEGYFCLELSNNLFAYFRGGQMPGTNIYFSNNGGFSFELLNSDRMSHLKGLLGGIFHFHSLSQVGILLVENNLGTFHYLEYPLNHSTGVPFLYESPLEVIIKPQQRGFLILWNQKTLLVSSNSGQIVEAMQLMEEGNINDLNVEHAKLTIHSIASNTYELAFLVEQDQLYYGSQSYMGNYIIKLSNQQFWSEEASVHFWDVGMLEVLTPVSDPYFPAFDFKKCLVNVQLALMDQSLQLEPCNVEFLESTMEDRMFIIDMNSKLKLSALMVPRKGMNPTPLVMVSNPHALGFKANLTQFGNMYDGNSKFKLDIELQQQQHWGNSELNFTASIKHEAISSITVDIADKTLSCVDLKPLSTLISVGCDLTKKVIVQNKISACAMGILDPVLLQKNYSYTIEKEAYNPTSYSGEAQDDLIVFYQYKELGCPRLVYYDKPWKPVVELWKDGTLEEIMNAEYVILELNGIVTYSYSLTAATAHCRSQPQNWSIFKEDAEKPSLWNRETYVSCHEDNQDNPLLWPNVEYQILGGRTDNKIIFGQRNGIYTFYLTVVDPYYSYCDLNTIFSVYVYGALPVAEFRPMTSILLMVTVTLFTMWLAYAIPKQLRTERGRRLTGFCFQIFKYCPGICTCAWLRGKMRRGLRSRRVKDQPEKIPQIGKKPDIKK
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.  Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
What are the official names of this protein?
Cation channel sperm-associated auxiliary subunit delta, CatSper-delta, CatSperdelta, Transmembrane protein 146.
What is the protein family that this protein belongs to?
Belongs to the CATSPERD family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail.
Protein: PSD_YERPA
Sequence: MLDSIKIKLQYLLPKQGLTQLAGWGANKQGGWLTQLVIKAFARYYKVDMKEAQDPEFSAYRTFNEFFVRPLRAGVRPVVAEENLLAQPADGAISQLGAIREGQILQAKGHNYSLEALLAGNYLLAAEFQNGQFVTTYLAPRDYHRVHMPCDGVLREMIYVPGDLFSVNPLTAANVPNLFARNERVICIFDTAFGPMAQILVGATIVGSIETVWAGTITPPREGVIRRWTYPQAGCEGAITLEKGQEMGRFKLGSTVINLFAEGKVYFAPQLNSGAVTRMGEVLAEAVPTTPSY
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DRC9_DANRE
Sequence: MTSVEELRACALLQDCADQLSVLGNIIRPGAETQQRTELHLKTAQLMAGSSLSNFSGELKSQKHFKIQQTLLASDNLAKVQKDRQFVSDVINALLEELQKKNNFQSLFSAVAEERKKKAELLDIINREEEGRRQIKKLQKQLLDIRKEKTEECERLEEEVAILKDQVQDMRVRTNQQGKFVKSCAEQLVYQESKHNSYKENELEDEVKMLQEKIEEEKNVHFETEAFLKQQHANLKQKLQYWIHRYEKDMEEKEQEITALQNKRNSSQTRIQDLSKKCKDMENVVIEDRIEKEHLRAQMEKEQREKNAATKIQAWWRGTLVRKGPRSKKADKSKKKDGKKGKKKRK
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity).  Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades.  Plays a role in the regulation of definitive hematopoiesis via its effects on camk4 (PubMed:24787902).
What are the official names of this protein?
Dynein regulatory complex protein 9, IQ domain-containing protein G.
What is the protein family that this protein belongs to?
Belongs to the DRC9 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Cell projection, cilium. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: CDC53_YEAST
Sequence: MSETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGESYAYLA
What is the function of this protein?
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme.  The functional specificity of the SCF complex depends on the type of F-box protein.  SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6.  SCF(CDC4) directs ubiquitination of GCN4.  SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2.  SCF(MET30) directs ubiquitination of MET4.  SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1.  SCF(MDM30) seems to direct ubiquitination of FZ01.  Involved in the regulation of methionine biosynthesis genes.
What are the official names of this protein?
Cell division control protein 53, Cullin-A, E3 ubiquitin ligase complex SCF subunit CDC53.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: INS2A_CONFO
Sequence: MTTSSYFLLVALGLLLYVCRSSFGSEHTCESDASPHPQGVCGSPLAEAVEAACELEESLQGGTGKKRGRASLLRKRRAFLSMLKARAKRNEASPLQRSGRGIVCECCKNHCNIEELTEYCPPVTEGSG
What is the function of this protein?
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock.  Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin.  In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
What are the official names of this protein?
Con-Ins F2, Insulin 2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDL_FINM2
Sequence: MQKNIYVLYGGPSTEHEVSITSARTLINNLSKEKYNVNAIFVRRNKKFIMKENITEEIKSDEELILDTDLSVIESVSECIRKINPENTVIFPAIHGSYGEDGTIQGFIKVLDLPFVGCNVLGSALCMDKGYTNDIFELNKIPQAKYVVLCKNDDYNLKEIFEKTSKAVYVKPCNAGSSVGVMRAETEEELEKAIQNAFQYDRRILVEEEIIGPELQIAVMGNDNPVASRPGVYQIHDVEFFDYDAKYNDSKTEMLTPFPMDEKLELKARHLAEKVYKLMSLSGFSRVDMFVKDNELWVNEINTVPGLTPHSMFPVLWKCTNDMSVSEVFDNLIGLAVEEYKKNKAYKLER
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_AROAE
Sequence: MIPELKKTTEQKMQKSIDVLKADLAKVRTGRAHTGLLDHVMVEYYGSMVPISQVSNVTLIDARTIGVQVWEKPMMQKVERAIRDSDLGLNPANQGDIIRVPMPALTEERRRDLTKVVRHEGEAAKVAIRNLRRDANQHLKDAVKDKTISEDDDRRAQEDIQKLTDRNIAEIDKLLAQKEQELMQL
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_RHOCS
Sequence: MDIRSHIRTVPDFPKPGILFYDISTLLAHAEAWKATVEKLAEAVAPHKPDLLVGIESRGFLVAAPLSLALGCGFAMVRKKGKLPGQTIRYTYDLEYGTDTVEIQADAIAPGQRVVVLDDLLATGGTMAAAIHLLRSVGADVTAAAFIMELAFLNGRDRLDVPAEVLISYES
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_PASMU
Sequence: MATLEQKLQELLQSSVEDLGCELWGIECQRAGRYLTVRLYIDKEGGVTVEDCADVSRQVSAILDVEDPIADKYNLEVSSPGLDRALFTLDQYQRYIGQEIVVHLRIPVLDRRKWQGKLEKIENDMLTLIVDGQEQILVFGNIQKANIIPKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_LISMO
Sequence: MLIIRNKQELKEVILKQKQANKTIGFVPTMGFLHEGHMTLVSHARKESDFVVMSVFVNPTQFGPNEDFDAYPRDEAHDAKLAEEGGVDILFVPTVEEIYPTELSTKLHVDKRVSVLDGADREGHFDGVVTVLTKLFHLVSPDNAYFGQKDAQQVAVVSGLVEDYFFPVNLRIIATVREADGLAKSSRNVYLTEKERKEAPVIHEALQLGRKLIESGETNQAKIVQMMTEKINEQTSHELIAYLAIYSYPEFTPVTDWSKGIIIAAAVKYSKARLIDNELINVKRR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCJF_ECO24
Sequence: MTEPLKPRIDFDGPLEVDQNPKFRAQQTFDENQAQNFAPATLDEAPEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRAFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETLQKGKTPSEK
What are the official names of this protein?
UPF0283 membrane protein YcjF.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS13_ALCBS
Sequence: MARIAGVNIPENKHTVISLTYIFGIGRTRAESICATTGIEQTAKVRELTGEQLDAIRGEVAKFSTEGDLRREINMNIKRLMDLGCYRGIRHRRGLPLRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MUTH_VIBC3
Sequence: MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSRPQQDFEHLGIELKSIPISYTGKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQGEREIPLAERCVGYPLLWSPSPEEEAQLKADWEELMELIVLGKVAQITAKHGEVLQLRPKAANGRALTEAYGANGRPIKTLPRGFYLRTQFTAQILQRYYA
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_SALTY
Sequence: MLIIETLPLLRQHIRRLRQEGKRVALVPTMGNLHDGHMKLVDEAKARADVVIVSIFVNPMQFDRPDDLVRYPRTLQEDCEKLNKRKVDYVFAPAVEEIYPHGLEGQTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLIQPDIACFGEKDFQQLALIRKMVADMSYDIEIVGVPIIRAKDGLALSSRNAYLTAEQRKIAPGLYNVMNSIAEKLIAGNRELQEIIAIAEQELNEKGFRADDIQIRDADTLLELTETSKRAVILAAAWLGQARLIDNQSVTLAQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXX_ECOLI
Sequence: MTSPVNVDVKLGVNKFNVDEEHPHIVVKADADKQALELLVKACPAGLYKKQDDGSVRFDYAGCLECGTCRILGLGSALEQWEYPRGTFGVEFRYG
What is the function of this protein?
Could be part of an electron transfer system required for anaerobic carnitine reduction.  Could be a 3Fe-4S cluster-containing protein.
What are the official names of this protein?
Ferredoxin-like protein FixX.
What is the protein family that this protein belongs to?
Belongs to the bacterial-type ferredoxin family. FixX subfamily.
Protein: TRPF_BACMK
Sequence: MKVKICGITDVETAKHACEYGADAIGFVFAESKRKITPGLAKEIIGEIPVHVFKVGVFVNESVEVIQKIAEECGLTHVQLHGDEDNHQIRRLNIPSIKAVGVALEKDIECAKKYDTDYLLFDSPKEKFHGGNGKTFSWELLAHMPNELREKTILAGGLNILNIEEAIRTVQPYMIDVSSGVETEGKKDLKKIKQFIKKAKECSK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MCTP2_MOUSE
Sequence: MDLDKPSVWGSLKQRTRPLLINLSKKKAKKSPSKPLDLRVQHHLDRRLSLSVPDLLEAEALAPEGRPYSGPQSSYISVPNSLSTAGIVPKSSSSSLKQSEEELDWSQEEASHVHGVDTDSEEIYASPAEEWQAFSQSALDLHKPSLGRDAPEEHDKTHGNDDLNASMTSQHFEEESTLGEASDCVSHLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPIWDEIVVLPIQSLDQKLRVKVYDRDLTKSDFMGSAFVVLRDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLRKNQLWNGIISITLLEGKNVSGGNMTEMFVQLKLGEQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDSKKHEERLGTCKVDISALPLKQDNCLELPLESCQGALLMLITLTPCTGVSISDLCVCPFEDPSERQQISQRYAFQNSLKDVKDVGILQVKVLKASDLLAADFSGKSDPFCLLELGNDRLQTHTIYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKAPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGLIYLELDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRLTLAIWNTVQFFKSCFQWESTLRSTIAFVVFLVTVWNFELYMIPLALLLLFLYNFLRPMKGKASSTQDSQESTDVEEEGKEEEKESEKKGIIERIYMVQDIVSTVQNILEEVASFGERIKNVFNWTVPFLSLLACLILAITTVILYFIPLRYIILLWGINKFTKKLRNPYSIDNNELLDFLSRVPSDIQKVQYAELKLCGSHSPLRKKRSTV
What is the function of this protein?
Might play a role in the development of cardiac outflow tract.
What are the official names of this protein?
Multiple C2 and transmembrane domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the MCTP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYH_SORC5
Sequence: MELRAVRGMNDILPEEVERWHKLEGAFRLHAELHGYAEVRTPLLEPTELFRHQMGETTDVVEKEMYSFERHGDHLTVRPEGTAGAARAYVEHAVHAKEPVTRWYYLGPMFRGERPAKGRYRQFYQAGCELFGDPGPLCDAETIDLVAGFLQRIGVGEFVVHVNSLGSAGTRERYREALLAHYTPRKAELSEDSQRRLEKNPLRILDSKDQRDHEVSRDAPSILDLLDDADRAHWDGVRRCLDVLGVNYVVDRSLVRGLDYYTRTLFEVKATAGDLGAQSTLAGGGRYDAMVAGLGGPSVPAIGFAMGMERLLTMMPGASPRRRPGCFLAPLGQSGADQALVLAKQLRALGVPVELDGRGGRLKAMLRRADSLGARLCVILGDAEIERGVLQIKDLVAHVQEEIPLEGAARVLADRALEAPPGGQRGAR
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_RUBXD
Sequence: MDREEILQKIQEITADRLGVDESEVTPEASFREDLEADSLDLVELIMELEEAFGMEIPDEEAEKITTVEEAVDYVVEHQTA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_HAEIN
Sequence: MATKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGNNVGMGRDHTLFATADGKVKFEVKGEKSRKYVVIVTE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: MARC1_XENLA
Sequence: MSNTVFSGAVGPLRAAALSISRHRLPLLCAAGLGLTAVASWMWWRKRQGEAEDLQQVGIVSQLLIYPVKSCRAVPVQEAECSALGLKSGHLEDRHWLVVTEEGNMVTARQEPRMVLISATFCGNTLCLNGPEMQEVQIPLPLPKSNRVLDCRVFGQDIQGRDSGEQASEWLATYFQSSQPYRLVHFEADVMRPRQSKKKEKLFRDKDVIAYPDASPIMLLSETSMEALNSRLEQPVSLANFRPCIVASGCEAFAEDDWDDVRLGATRLKRVMACGRCVLTTVNPNSGVITRKEPLDTLRTFRQSDSSLKEVYKNAPLFGQYYGVEQTGIIRVGDPVYRVTRKG
What is the function of this protein?
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles.  As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability.  May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis.  Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
What are the official names of this protein?
Mitochondrial amidoxime-reducing component 1, mARC1.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-44 and requires ATP.
Protein: HEM1_PROMA
Sequence: MNIAVVGLSHRTAPVEVREKLSISDEHIEKSFCSLNATEQVLEVSILSTCNRLEIYALVKNQELGVSAIKEFLIDHSGLSKEDLFPHLFTFNQAEAVNHLMRVSGGLDSLVLGEGQILSQVKKMVRLGQDYKSIGPILNRLLTQAVSTGKKVRSDTNLGTGAVSISSAAVELAQLKLGQSLGKDQLMTLQSEKVAVIGAGRMSRLLIQHLQSKGCSKLTLLNRTLNRAESLAKDFPDLDVKCGLLDDLDKCIEFSTLIFTSTASNTPIINSELLSGFKRNNNLLRLIDIGVPRNIASDVSGLPGFEAYDVDDLQEVVARNQDARQQIAIEAQNLIDEEARVFLEWWASLEAVPTINRLRSNLESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTNLRAPQPSSQRKESLKIVESLFELGVSENDQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PGK_PSE14
Sequence: MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVSSDARILASLPTIRLALEKGAAVMVCSHLGRPTEGEFSAENSLKPVADYLSKALGRDVPLVADYLDGVDVKAGDVVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELEALGKALGAPAQPMTAIVAGSKVSTKLDVLNSLSGICNQLIVGGGIANTFLAAAGHKVGKSLYEPDLLDTARAIAAKVSVPLPTDVVVAKEFAESATATVKLIADVADDDMILDIGPQTAAHFAELLKSSGTILWNGPVGVFEFDQFGEGTKTLAKAIGESQAFSIAGGGDTLAAIDKYGVAEQISYISTGGGAFLEFVEGKVLPAVEVLEQRAKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFDL_ECOLI
Sequence: MLQEELCSVVEASGASLEKGRHDQLLTALRALLLSRKNPFGDIKLDGTVQKALENLGLGEAAKRNVGTGANQIPDMGSFMLSASVPGYQKLPSGLIIQWGPIDVPLTSQDTVTYFPIAFPNRCLRVFATQDYTPGSANVGYIACAGYNQDPVKFISRAGVPGIGASFFALGC
What are the official names of this protein?
Putative uncharacterized protein YfdL.
What is the protein family that this protein belongs to?
To E.coli StfP and M.jannaschii MJ0347.
Protein: GLGC_LIGS1
Sequence: MKNEMLGVILAGGKGTRLGKLTHNQAKPAVPFGGRYRIIDFTLSNCVNSGVKNIGVITQYQPLNLNAHIGNGASWGLDDLNAGVTILQPYSNNEGSKWFEGTAHAIYQNIGYIDQMDPEYILILSGDHIYKMDYEAMLDQHKETGASLTVAVIDVPWDEASRFGIMNTDDNNRIIDFEEKPAEPKSNHASMGIYIFNWKRLREVLVNSFTRNQDMVDFGKNVIPYYLKSGESVFAYNFKGYWKDVGTIDSLWHANMEFLDENNELNLQDRTWRIYSRNPIAPPQIIAETAEIKDAMIVDGSYIAGKVDHSILSANVRIQTGSVVTDSVIMPGAKIGKNVTIHRAIIGEGAVIGDDVVIDGTDEIAVIGNKEVVGVTSHEE
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: PP11_DROME
Sequence: MSDIMNIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKRRFVYPNFGSSGRPLTPPRGANNKNKKK
What are the official names of this protein?
Serine/threonine-protein phosphatase alpha-1 isoform.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
Protein: CPD_ARATH
Sequence: MEEVKKDVYSVWALPDEESEPRFKKLMEALRSEFTGPRFVPHVTVAVSAYLTADEAKKMFESACDGLKAYTATVDRVSTGTFFFQCVFLLLQTTPEVMEAGEHCKNHFNCSTTTPYMPHLSLLYAELTEEEKKNAQEKAYTLDSSLDGLSFRLNRLALCKTDTEDKTLETWETVAVCNLNP
What is the function of this protein?
Hydrolyzes ADP-ribose 1'',2''-cyclic phosphate (Appr>1) that is produced during tRNA splicing into ADP-ribose 1''-phosphate (Appr-1''p) (PubMed:9148938).  Acts also on nucleoside 2',3'-cyclic phosphates (PubMed:9148938).
What are the official names of this protein?
Cyclic phosphodiesterase, CPDase.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. CPD1 family.
Protein: SPCS_HUMAN
Sequence: MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDNVLLDTYQDASS
What is the function of this protein?
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein.
What is the protein family that this protein belongs to?
Belongs to the SepSecS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_BART1
Sequence: MRVVLLGPPGAGKGTQAKMLTEEYNIPHLSTGDMLREVIAKETEVGKKAKAIISSGALVPDSIVNQIVSDRIDEADCINGFILDGYPRTVGQAEALQQILESKNMRLDAVIELCVNEDALIERMERRVQETVAAGGQVRLDDNPVAFAKRLVEYREKTSPLSKFYSERGMLKVIDGMIGIAEVTRIIKGFLS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.