PharMolix/UniProtQA huggingface dataset:
Protein: PSA1_TRYBR
Sequence: MFKNQYDTDTTTWSPTGRLFQVEYANEAVNNGSAAVGVKGADYVVLTALKRNPVSGLSSYQEKAFKLDEHVGMAISGLVADGRALSRFLRTECMNYRYMHDSDAPLVMLADIVGAKHQRHIQFAGKRPFGVGLLIAGYDRQGPRLYQTVPSGDVFDFKATAMGLRSQAARTYLERHFRGFPACDLDELVMHALRALGAATSGGVELNIKNTTIAIVGKGTPFTILTEEEARKYLDGFKTRPEDIPAVADNEEDDDELHEQPPDVEE
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-1, 20S proteasome subunit alpha-6.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCOR_HUMAN
Sequence: MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
What is the function of this protein?
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.  Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
What are the official names of this protein?
Ornithine decarboxylase, ODC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: YUNG_BACSU
Sequence: MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGTIFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLREAFSRHMNSISEET
What are the official names of this protein?
Uncharacterized protein YunG.
Protein: RS18_THET8
Sequence: MSTKNAKPKKEAQRRPSRKAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSAKEQRILAKTIKRARILGLLPFTEKLVRK
What is the function of this protein?
Located on the back of the platform of the 30S subunit where it stabilizes the close packing of several RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it probably interacts with the Shine-Dalgarno helix.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SMD3A_ARATH
Sequence: MSRSLGIPVKLLHESSGHIVSVEMKSGELYRGSMIECEDNWNCQLENITYTAKDGKVSQLEHVFIRGSLVRFLVIPDMLKNAPMFKDVRGKGKSASLGVGRGRGAAMRAKGTGRGTGGGRGAVPPVRR
What is the function of this protein?
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).  May play a minor role in the splicing of cellular pre-mRNAs (PubMed:21421416).
What are the official names of this protein?
Small nuclear ribonucleoprotein SmD3a, SmD3-a, snRNP core protein D3-a.
What is the protein family that this protein belongs to?
Belongs to the snRNP core protein family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Protein: CLPB_HUMAN
Sequence: MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHPEKVCNTI
What is the function of this protein?
Functions as a regulatory ATPase and participates in secretion/protein trafficking process.  Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).  Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842).  Plays a role in granulocyte differentiation (PubMed:34115842).
What are the official names of this protein?
Caseinolytic peptidase B protein homolog, Suppressor of potassium transport defect 3.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: ZDHC9_MOUSE
Sequence: MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPASTEHMNSNEMAEDTSIPEEMPPPEPPEPPQEASEAEK
What is the function of this protein?
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.  The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.  May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
What are the official names of this protein?
Palmitoyltransferase ZDHHC9, Zinc finger DHHC domain-containing protein 9, DHHC-9, DHHC9.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: Y513_MYCBO
Sequence: MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR
What are the official names of this protein?
Uncharacterized protein Mb0513.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: ACDB_ARCFU
Sequence: MVERKRIEIPEGVKVKESVGEEAEFPFDISPMYEGERIRKGDMYVELGGPTQPGFELVMALPMDQVEDMKVTLIGPDLDEMEEGQAYPYAMIYYIAGEMVETDLEPVIERRNHDFQNYIEGYMHLNQRYDIWIRIGKNAIKKGLKSLIQIAKATMMLYKNELPFIEKIEAVYITDKDLVEKLLNELAMPIFEERDARVEALSDEDVDEFYSCTLCQSFAPTNVCIVSPDRPSLCGAITWFDGRAAAKVDPEGPNRAVPKGELLDPIGGEYSGVNEFAKQESGGEYERIKLHSFFEYPHTSCGCFEVIGFYMPEVDGIGWVHRGYAEPAPNGLTFSTMAGQTGGGKQVVGFLGIGIAYFRSKKFIQADGGWYRTVWMPKELKERVAKYIPDDIRDKIATEEDAKTLDELREFLKKVDHPVVKGVVRPVDGKKITNGWVEEEEEEAEEVAEEAAAEAAPAAQPAQAAQPMAMQPMPMQMPGFQLPALQMPAASAAPAGVKLVIKDAKITIEKVIIKKAEKEKKGGK
What is the function of this protein?
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).  The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA.  The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit beta, ACDS complex subunit beta, ACDS complex acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CdhC family.
Protein: LEC_CROJU
Sequence: AEEQSFSSTKFSTDQPNLILQGDA
What are the official names of this protein?
Lectin.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: RL27_PARDP
Sequence: MAHKKAGGSSRNGRDSAGRRLGVKLYGGQLAVAGNIIVRQRGTTWWPGQNVGMGRDHTLFALTDGHVTFKKGLKGRTYISVLPANLEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LUXS_BIFLS
Sequence: MTEGKAEKPVVESFQLDHTKVKAPYVRYIDTETGPHGDVISNYDLRLTQPNKQAIPTGGLHTIEHTIAVLLRERIPGYIDCSPFGCRTGFHLLTWGTHSTEDVAKALKESLEFIAYKATWDDVPATTEKSCGNYRDHSLFAAKEWAKQILEEGISSDPFERKVV
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PPOX2_ARATH
Sequence: MGTHVAPWKQLLFGAIEANSHLSHSSYVQLATIGLNGRPSNRTVVFRGFEENSDRIQINTDLRSRKIEELKHCPFSEMCWYFSDTWEQFRINGRIEVIDASNPDQTKLQQREKAWFANSLRSRLIYVCPTPGSPCNSEQSSQQVKLDPSSGPVPEYCLLLLEPEKVDYLNLKTNQRLFFSSMATGTGEKCWTSEKVNP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).  Has an in vitro catalytic efficiency for PNP approximately 300-fold lower than that of PPOX1.
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase 2, AtPPOX1.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: FOLD_SALA4
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGFVSRSYDLPETTSEAELLALIDTLNADNTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFDEAAARASYITPVPGGVGPMTVATLIENTLQACIEYHDPQGK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DER_BACHK
Sequence: MPKPVIAIVGRPNVGKSTIFNRIVGERVSIVEDIPGVTRDRIYSAGEWLNHEFNIIDTGGIDIGDEPFLTQIRQQAEVAIDEADVIIFMTNGRDGVTAADEEVAKILYRSNKPVVLAVNKVDNPEMRSDIYDFYALGFGEPFPISGTHGLGLGDLLDEAAQHFPKIEEDGYDEDTIRFSLIGRPNVGKSSLVNALLGQERVIVSNVAGTTRDAVDTPYSKDGKDYVIIDTAGMRKKGKVYESTEKYSVLRALRAIERSDVVLVVLDGEEGIIEQDKKIAGYAHDSGRAVVIVVNKWDAVKKDEKTMKAFEENIRAHFQFLEYAPIVFLSAKTRKRTQTLIPVIDEVNESHSIRIQTNVLNDVIMDAVAMNPTPTHNGSRLKIFYATQVAVKPPTFVVFVNDPELLHFSYERFLKNRLRESFGFVGTPIHIIARARD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATPA_ECO81
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPLDHDGFSAVEAIAPGVIERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSFEAALLAYVDRDHAPLMQEINQTGGYNDEIEGKLKGILDSFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: G6PI_PSEFL
Sequence: MAYYRTPHDVTALPAWQALNDHRKAMQDFSMREAFNADPQRFTQFTLSSCGLFLDYSKNLINAQTRDLLVGLANEVDLKGAIKSLFEGEIVNASENRPALHTALRRPVGDKLLVNGVNVMPDVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGGSFLGPELVSEALLSYAQKGVRCHYLANIDGSEFHELTMKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAELYRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSGAYSMDQHFQSAPFEQNMPVLLALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMESNGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPIVSFNPVSDHHQWLYANCLSQSQALMLGKTRAEAEXELRDKGASEEEVQKLASHKVIPGNRPSNTLVVERISPRRLGALVALYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEESLAEDASTQGLINYFRGRHRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INHBA_RAT
Sequence: MPLLWLRGFLLASCWIIVRSSPTPGSEGHGAAPDCPSCALATLPKDGPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDMGDEAEEMGLKGERSELLLSEKVVDARKSTWHIFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEVDGDGKKKDGSDGGLEEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta A chain, Activin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOC_BURP6
Sequence: MKALLDLFKQVQQEEIFDAIKIGLASPDKIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRLKHRGVICEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVIDPGMTPLKARQIMTEEDYYNKVEEYGDEFRAEMGAEGVRELLRSINIDEQVETLRTELKNTGSEAKIKKYAKRLKVLEAFQRSGIKPDWMILEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKLMALELFKPFIFNKLEVMGVATTIKAAKKEVENQTPVVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLFPANGDPSIVPSQDIVLGLYYATREAINGKGEGLSFTGVSEVIRAYENKEVELASRVNVRITEMVRNEDTSEGAPQFVPKISLYATTVGRAILSEILPPGLPFSVLNKPLKKKEISRLINTAFRKCGLRATVVFADQLMQSGFRLATRAGISICVDDMLVPTQKETIVGDAAKKVKEYDRQYMSGLVTAQERYNNVVDIWSATSEAVGKAMMEQLSTEPVIDRDGNETRQESFNSIYMMADSGARGSAVQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSNGVAMKALVEGGEVVEALRDRILGRVAASDVVNPETQETLYEAGALLDETAVEDIERLGIDEVRVRTALTCETRYGLCASCYGRDLGRGSLVNVGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAVASSVEAKSNGTVRFTASMRYVTNAKGEQIVISRSGEALITDDIGRERERHKIPYGATLLQLDGAAIKAGTQLATWDPLTRPIITEYGGTVKFENVEEGVTVAKQIDDVTGLSTLVVIDVKRRGSQAAKSVRPQVKLLDANGDEVKIPGTEHAVQIGFQVGALITVKDGQQVQVGEVLARIPTESQKTRDITGGLPRVAELFEARSPKDAGILAEVTGTVSFGKDTKGKQRLVITDLEGNQHEFLIAKEKQVLVHDGQVVNKGEMIVDGPADPHDILRLQGIEALSRYIVDEVQDVYRLQGVKINDKHIEVIVRQMLRRVQIVDNGDTRFIPGEQVERSDMLDENDRMIAEDKRPATYDNILLGITKASLSTDSFISAASFQETTRVLTEAAIMGKRDDLRGLKENVIVGRLIPAGTGLAFHKARKAKEQSDRERFDQIAAEEAFEFGTPSAPAEEPQHPAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: YOR1_YEAST
Sequence: MTITVGDAVSETELENKSQNVVLSPKASASSDISTDVDKDTSSSWDDKSLLPTGEYIVDRNKPQTYLNSDDIEKVTESDIFPQKRLFSFLHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMSIVFAILANCTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGYPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLSYWTENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSRSGIVENDFENRS
What is the function of this protein?
Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol.  Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups (PubMed:8663018).  Required for tolerance to reveromycin A, tautomycin and leptomycin B (PubMed:8663018).  Required for oligomycin resistance (PubMed:8524254, PubMed:10082567).  Required for rhodamine B resistance.  Mediates the ATP-dependent efflux of rhodamine B (PubMed:9575223).  Involved in cadmium detoxification.  Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex (PubMed:16814918).  Confers resistance to rhodamine 6G and to doxorubicin (PubMed:17950691).
What are the official names of this protein?
Oligomycin resistance ATP-dependent permease YOR1, ABC transporter YOR1, ABC-type Cd(2+) transporter, ABC-type glutathione-S-conjugate transporter, Yeast oligomycin resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGA_BACVZ
Sequence: MNIQDMILTLQKHWSNEGCVLMQSYDVEKGAGTMSPYTFLRSIGPEPWRVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGIDPLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGIECKPVSVEITYGIERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFHLFSTYEKEAIRQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIGRVRNLARKVAKTYYEEREKLGFPMLKEEGSSHE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEGLY_THEKO
Sequence: MKVLILSADGFEDLELIYPLHRIKEEGHEVYVASFQRGKITGKHGYTVNVDLAFDEVDPDEFDALVLPGGRAPEIVRLNEKAVAITKKMFEDGKPVASICHGPQILISAGVLKGRKGTSTVTIRDDVKNAGAEWIDAEVVVDGNWVSSRHPGDLYAWMREFVKLLR
What is the function of this protein?
Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage.  Also displays proteolytic activity.
What are the official names of this protein?
Deglycase TK1284, Intracellular protease TK1284.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXG_PINMS
Sequence: MASNESLQTTAAMAPVTIERRVNPNLDDELPKPFLPRALVAVDTEHPSGTPGHQHGDMSVLQQHVAFSNRNNDGIVYPWETFLGFRAVGFNIIISFFGCLIINIFLSYPTLPGWIPSPFFPIYIDRIHRAKHGSDSEVYDTEGRFVPAKFEEIFTKNAKTHPDKLSFSELWNLTEHNRNALDPLGWIAAKLEWFLLYSLAKDPHGFVPKEAARGVFDGSLFEFCEKSRKVKQATVKSLTFKI
What is the function of this protein?
Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies.
What are the official names of this protein?
Peroxygenase, Caleosin.
What is the protein family that this protein belongs to?
Belongs to the caleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Microsome membrane.
Protein: RL31_LEPBL
Sequence: MKTEIHPNYKAAKISCASCGTVYETRTSIGDINIEICSACHPFFTGKSKLVDTTGRVDKFKKKYKMQ
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: CAR7_ARATH
Sequence: MEELVGLLRIRVKRGINLAQRDTLSSDPFVVITMGSQKLKTRVVENNCNPEWNEELTLALRHPDEPVNLIVYDKDTFTSHDKMGDAKIDIKPFLEVHKMGLQELPDGTEIKRVVPNRENCLAEASSIVSNNGKIVQNMILLLRNVECGEVEIQLEWIDIPGSRGL
What is the function of this protein?
Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity).  Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity).
What are the official names of this protein?
Protein C2-DOMAIN ABA-RELATED 7.
What is the protein family that this protein belongs to?
Belongs to the plant CAR protein family.
What are the subcellular locations of this protein?
Cell membrane. Nucleus.
Protein: MCL1_FELCA
Sequence: MFGLKRNAVIGLNLYCGGAGLAAGSGGASSSGGRLVAVGKEATARREVGGGEAGAVIGGSAGASPPATLAPDARRVARPSPIGAEGPDVTATPPKLLFFAATRCASPPEEMEGPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGEASSGPGTDGSLPSTPPPAEEEEDELFRQSLEIISRYLREQATGAKDAKPLGGSGAASRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNENDVKSLSRVMVHVFSDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
What is the function of this protein?
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation.  Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).
What are the official names of this protein?
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.