PharMolix/UniProtQA huggingface dataset:
Protein: ARMD3_ARMGA
Sequence: MGNVWSLTSQMFPPKPKWTVDDMPDLTGKVVIVTGGNTGCGKESVRVLLLHGAKVYLAARSEGKAKEAIEDLKKETGHEAIFLPLDLADLVSVRRGAEEFLSKEKQLHILFNNAGVMLSPMEMLTKQGYDLQFGTNVIGHFHFTKLVLPALLAAATPTEKARVITTSSSANYMGTLNFDLWADGPARNKKAPGDMYVQSKHGNVVFAVELARRYGAQNIISHSLNPGSIRTDLQRHLSPFANKMQDIFLFPVSMGALTQLWAGTSPEAGQMNGEFMIPWARLGKARKETGDPEVGKKLWEWLEAQCKDY
What is the function of this protein?
Short-chain dehydrogenase/reductase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols (Probable).  The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene (PubMed:21148562).  The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (By similarity).  ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (By similarity).  The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (By similarity).  The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (By similarity).  The role of the NAD(+)-dependent enzymes remains unknown (By similarity).  Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (By similarity).  The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (By similarity).  Finally, several halogenase localized outside of the cluster, are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (By similarity).
What are the official names of this protein?
Short-chain dehydrogenase/reductase ARMGADRAFT_1048226, Melleolides biosynthesis cluster protein ARMGADRAFT_1048226.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HEAT6_RAT
Sequence: MSALPGSKLSERVRTVGWQISRPYFCHFFPIRITAPPATCSANKGFPELEHARPCPKRCPGSISQAIHVGKMAAVQVAASLPCEQPREAPRELSLEQNNGFRRLSARLRALQPDDSTVSRMEIHLLFDQLISENYCEGGGVAPEDVSALLVRACQLVPLNQNHLVSKVSQLIHRLLNRLQVIVDEQNLDFLLTYTISAIQQCSPWTHMEILQALAALVYCNGSKCQKHLPDLLGKSGLLMKLSDVTHSDPEVRRAAVHCMANLCLSVPGQPYLEESYQLVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPGLNIEMPAVLYPTPLPQYDGRSPVKPQQPESSAARPSANKKKKYKVKPKKTQQGEKAEEEEPYGEVDAAPGLSMDQANTCVESAWCSSPWGSQGLPVDGGRATGREQVSSPFTISSWKRVSSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAVVSTHAPLPEVQLLLQQPCSSGRSSSSATPHLSTPDGWKALPAGPSLEEASLSSPKGTAEPCWLIRLCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAHLARGYFSMAQLYLMELGEVICKCMCEANPSIQLHGVKLLEELGTGLIQQYKPDSSTAPEQRVPVHMVAMFWTAMLNGPLPRALQSTEHPTLQASACDALSSILPEAFSSLPNDKQILCITMLLGLNDSKNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQDEFSGLLLLKMLQSAIQASTDKDKVKSNAVRALGNLLHFLQPSHIERPRFAEIIEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVPGRRAQYGSLEQFSQIWSALVTALQRSEDTTDFLEFKYCASLRTHVCQALLHLLGLASASDLPCIQETLTVNGDMIRSYILQFLKSGAGGDDPGAVHSPQERNQMVRVALRHIHSVQALAGDTAKGAIVGFLEDILTVHCDSSGERAVLRGSLDQ
What are the official names of this protein?
HEAT repeat-containing protein 6.
Protein: CIDEB_MOUSE
Sequence: MEYLSAFNPNGLLRSVSTVSSELSRRVWNSAPPPQRPFRVCDHKRTVRKGLTAASLQELLDKVLETLLLRGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLEQGQSWSPKSGMLSYGLGREKPKHSKDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKRVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGADRWQWHGQRHLHS
What is the function of this protein?
Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:26733203).  Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:26733203).  Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity).  The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity).  Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (PubMed:26733203).  In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (PubMed:19187774, PubMed:23297397, PubMed:30858281).  Required for very-low-density lipoprotein (VLDL) lipidation and maturation (PubMed:19187774, PubMed:23297397).  Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (PubMed:23297397).  Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (PubMed:30858281).  May also activate apoptosis (PubMed:9564035).
What are the official names of this protein?
Lipid transferase CIDEB, Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B.
What is the protein family that this protein belongs to?
Belongs to the CIDE family.
Protein: CK071_MOUSE
Sequence: MAQNSVSLSAGDQANRMAHRSSQGDLNPSAMAWAMVSGDSFLVTRLDPNQPGPRPPARPSVRADRRRVPVGGRSRSRSRQGRFSPYPIPGVKLDLLRSVLQQRLVALGTALATRISA
What are the official names of this protein?
Uncharacterized protein C11orf71 homolog.
Protein: XNI_VIBVU
Sequence: MAIHLVIIDALNLIRRVHSAQPDPTDIANTIQNTRRTLQRIISESHPTHIVAVFDHLGSDRGWRAEILPEYKQGRKPMPEPLLNGLEKIQEAWWQLGIDSLLSEGDEADDLVATLACKVAQHGEKVTIISTDKGYCQLLSPTLQIRDYFQHRWLDQPFIEQEFGVKPQQLSDYWGLTGISSSQVTGIPGIGPKAAKEILSQFDDIEQAFLSPDLPKKYRTKFDQHIELARRCKRVSALKTDIELGFNLQDLRFTANEAR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: RL35_RHOJR
Sequence: MPKSKTHSGTAKRFKVSGSGKILRQKAGRRHLLEHKATKVTRRLDGVAVVSKADTPRIKRLLDI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ABD18_RAT
Sequence: MGVSKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKVEEQSDCKILDGHFVSPMAHYVPGIMPIESVIARFQFIVPKEWNSRYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYILLKPKDQVRSSLKNVSDLFVMGGALILESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLSKSINWRELEKQYYTQTVYEEEIIHMLEYCGTDSFKMGHEFMKHFPSNEDKLTNLNLVSRTLNLDMRDQVVSPKHAECHHSGKASISATSKGQLLQDTAKVERLNQTLTTNKSCFASYNPQSLHLLSREQRRSNLQKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQAIYDAFERFLHKYAN
What are the official names of this protein?
Protein ABHD18, Alpha/beta hydrolase domain-containing protein 18, Abhydrolase domain-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PTH_NITOC
Sequence: MATTTWLLIGLGNPGTEYAQTRHNAGFWWLDAFASELGINFKPGAKFFGDYARANWRGHDLWLLKPATFMNRSGQAVLALLNYYQIPLEHLLIAHDDLDLPPGVAKLKRAGGHGGHNGLRDIINRLGRRDFLRLRLGVGHPGSGQDVVSYVLNRPSREDRQAIEAAIGAGLEVLPEVLAGEMEKAMHRLHSQS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPSC_MACPH
Sequence: MTSSTESKHSNDESTDLEKQDAEESHGLPEERKQDIAAQLSSSDVQDPNLVDWDGPDDPANPMNWPKSKRLGHVVMASLTTLFANITSTAFAPAASSLEAEFGITSSITAALTVSIYLLGFAFGPLVIAPLSEHFGRLPVYRVCTVITVAFLIGCAQAKNLGMFLVFRLITGIAGSGPGTIGGGTIADVMAPENRGKAMGAFAMGPLMGPVLGPLMSGFIAQYLDWRWVFRVLCIATGVMTIVLYFVMTETYGPVLLKRKAARLRKETGNPDLHTKLEASGVSPLASLWMALQRPTKMLIFSPITLLLSLYCAFVFGLLILLFTTFSAVYRQQYGFNVSMGGLSYLGLGFGLAIGLVLFGMLSDKVAKKDSARSSEWKPEARLLLMVWFAPVIPGGFFWYGWTAYYKVHWILPMMGTSLIGMGALMVMMPIQVYLVDAFGPRVAASALAANTLLRSLAGCFLPLAGPSLYEALGLGWGNTLLGFIAIGFTCLPILFYRFGGKLRLRFPVTF
What is the function of this protein?
MFS-type transporper; part of the gene cluster that mediates the biosynthesis of macrophasetins, 3-decalinoyltetramic acids (DTAs) which feature a tetramate (pyrrolidine-2,4-dione) unit connected to a decalin fragment and that have potent bioactivities (PubMed:36452919).  Efflux pump that might be required for efficient secretion of macrophasetins (Probable).
What are the official names of this protein?
MFS-type transporper mpsC, Macrophasetins biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
Protein: RIMO_PHOV8
Sequence: MKRNTIDIITLGCSKNLVDSEKLMRQLEANGYKVTHDSDKPQGEIAVINTCGFIGDAKEESINMILEFCQAKEEGKLKKLYVMGCLSERYLKELALEIPQVDKFYGKFNWNELLADLGKAYKSEFAIERTLTTPHHYAYLKISEGCDRKCSYCAIPIITGRHISRPMEEIIDEVKLLVSEGVKEFQIIAQELTYYGVDLYKSQKLPELIERIANVPGVEWIRLHYAYPAHFPEELFRVMREHDNVCKYMDIALQHISDNMLNKMRRHVSKAETYELIEKFRREVPGIHLRTTLMVGHPGETEEDFEELKEFVKKVRFDRMGAFAYSEEEGTFAAKEYEDSISHEVKQQRLDELMALQQEIAGELSQTKIGKEFKVIIDRKEGDYYIGRTQFDSPEVDPEVLIKADEEYLKIGEFYKVKITAADDFDLYASIL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNS_DESVM
Sequence: MKISIGLGKEGVEERLAERGVSRRDFLKFCTAIAVTMGMGPAFAPEVARALMGPRRPSVVYLHNAECTGCSESVLRAFEPYIDTLILDTLSLDYHETIMAAAGDAAEAALEQAVNSPHGFIAVVEGGIPTAANGIYGKVANHTMLDICSRILPKAQAVIAYGTCATFGGVQAAKPNPTGAKGVNDALKHLGVKAINIAGCPPNPYNLVGTIVYYLKNKAAPELDSLNRPTMFFGQTVHEQCPRLPHFDAGEFAPSFESEEARKGWCLYELGCKGPVTMNNCPKIKFNQTNWPVDAGHPCIGCSEPDFWDAMTPFYQN
What is the function of this protein?
Catalyzes the reversible oxidoreduction of molecular hydrogen, in conjunction with a specific electron acceptor, cytochrome c3.
What are the official names of this protein?
Periplasmic [NiFe] hydrogenase small subunit, NiFe hydrogenlyase small chain.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GRPE_LACPL
Sequence: MAKKSTRTTPEDSQASTTDSAATSTASEATQAATSATDDQAEQTTAVDPTQQITDLKAQLDAKDDQLLRAQAEIVNMQNRNKKEQAALLKYDGQALAKDVLPVLDNLERALATPADDEAAQQLKKGVEMVYGHLQDALKKHGVTEVAAAGEKFDPNIHQAVQTVPVDDDHPADTVVQVLQRGYLLKDRTLRPAMVVVAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_RHIE6
Sequence: MRLSRYFMPILKENPKEAEIVSHRLMLRAGMIRQQSQGIYSWLPLGKRVLDKVNAIIREEQNRAGAIELSMPTLQSAELWQESGRYDAYGKEMLRIKDRQERPMLYGPTNEEMVTDIFRSSVKSYKDLPLNLYHIQLKFRDEIRPRFGTMRSREFMMKDAYSFDLTREGAEHSYNKMFAAYLRTFDRLGLRAIPMRADTGPIGGNLSHEFIILADTGESEVFCHKDFVDFDIPGESTDFDSVEGLQAIFDKWTSLYAATSEMHDEAAFNAVPEGERLSARGIEAGHIFYFGTKYSEPMGAKVQGPDGKEHFVHMGSYGIGPTRLVPAIIEASHDDNGIIWPASVAPFDVVVINMKAGDQACDDTCELIYAALTKAGKDVLYDDTDDRAGTKFATADLIGVPVQIIAGPRAVANGEVEVKDRKTGARETMTIEAAINRFVA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_LAWIP
Sequence: MSEQLVAVGVLSRPHGIKGEIRLIRYTDSIDVFLGEVFLQKSNSLPKKAEIISSRIHQGVALVCFKGFSDRSAVEVLRGQTLLVSRSFLPEIESNESYLCDLLGFSVVLDNTDEVIGKLEYVSFPGGQELWSIITPEGKEVLLPAIPEFVLEVDTNAQLIRINPPKGLLELYK
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_PHOLL
Sequence: MAAKDVKFGSDARVKMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPAITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIVTEGLKAVAAGMNPMDLKRGIDKAVVAAVAELKKLSVPCSDSISIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEEGTGLEDELDVVEGMQFDRGYLSPYFINKPENGSVELENPYILLVDKKISNIRELLPVLEGVAKASKPLLIVAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLHDIAVLTNGNVISEEIGLELEKATLEDLGQAKRIVINKDTTTIIDGVGEEDAIKGRVSQINQQIKESTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKRARVDDALHATRAAVEEGVVAGGGVALVRVAAAIVGLKGDNEDQNVGIRVAMRAMEAPLRQIVDNSGEEPSVIANSVKAGEGNYGYNATTEQYGDMIAMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKDDKADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPYK_STAHJ
Sequence: MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGSHEEHKARIDTIRKVADRLGKTIGILLDTKGPEIRTHDMKDGLIMLEKGKEVIVSMSQVEGTPEKFSVTYEDLINDVQVGSYILLDDGLVELQVKDIDKTKGEVKCDILNTGELKNKKGVNLPGVKVNLPGITDKDADDILFGIKEDVDYIAASFVRRPSDVLDIREILERENNHNITIFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPESVPIVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGVSVAHTALNLNVKAIVAATESGSTAVTISKYRPHSDIIAVTPSEHTARQLALVWGAYPVIKKGRKTTDDLLNNAVATAVETGRVTNGDLIIITAGVPTGEKGTTNMMKLHLVGDEIAKGQGVGRGSVVGKTVVANSASDLEGVDLSESVIVTNSVDETLVPYIEQAVGLITEENGITSPSAIIGLEKSIPTIIGVENATKELKDGILVTVDAAQGKIFEGYANVL
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PEP-utilizing enzyme family.
Protein: PYRR_CLONN
Sequence: MEFKSILLDEKAIKRTLTRIAHEIIEKNKGVEDIVLLGIQRRGVPIARRIAALIEQFEDVKVEVGSVDITLYRDDLTEVAEQPLLNEKSLDIDVKNKKIILVDDVLFTGRTARAAMEAVIKHGRPDNIQLAVLVDRGHRELPIRADYVGKNVPTSKKELVSVMVSEIDSEDAVKIFEK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: TRHO_BACVZ
Sequence: MEKQYRVLLYYKYVKIDEPEEFTAQHLKFCKELGLLGRILISEEGINGTVSGTVEQTEQYMNALKADPRFADMPIKIDEADGHAFRKMFVRHKKELVTLRLEDDVDPNVTTGKHLKPKDFYEQMQDPDTIVIDARNDYEYDLGHFRGAVRPDIEAFRELPDWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLLKKGFEDVSQLDGGIVTYGKDPEVKGQMWDGQCYVFDERISVPVNRVEHVIIGKDYFTGEPCERYVNCANPACNKKMICTPENEYKYMRSCSHECRTNERNMYVKEHDMTQEEINERLALIEKEDHAAID
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: SODM_NEUCR
Sequence: MVNLGSIWQNLLASQAPLQSMTGNATTMAGLATYSLPQLPYAYNALEPYISAQIMELHHSKHHQTYVTNLNNALKVHVAAIASSDIPAQIAQQPAIKFNGGGHINHSLFWKNLAPAETPETNYSKAAPSLAAEIEKTWGSFDEFKKAFSAALLGIQGSGWGWLVKESTAEKGRLRIITTKDQDPVVGGEVPVFGVDMWEHAYYLQYLNGKAAYVENIWKVINWKTAEERFQGSREDAFADLKALL
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn], mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y761_TREPA
Sequence: MNSNSNKKRDPARFPAGVAQGCSTTRAGDLKHRRKHPFEKFFAQNSALFAQRFPDLARALTLPNEQLLQRIPPDYLLAAAHDGDATLAVRGTYLHSKYRPRQEAARLISQDFFTHAIAKGGYVGAGLGLGYVAELYAQQHPTHTVVLIEPDIFVFLLFLASRPLTPLLRHERLKILPAQTVPDVLQFLRATGDVSLPLFHFLPAQELNTAWFHDFTQAHRHATAQAETNKQTLQRFGPLWIRNTIKNAAQLCVRTPVNALRNCAAGSTALIIAGGPGVDASISFLPYLKKKH
What are the official names of this protein?
Uncharacterized protein TP_0761.
Protein: TUSB_SALDC
Sequence: MLHTLPHCASSVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTDFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_CLOPE
Sequence: MGKFEDKKQLRCSFCGKNQEQVKRLIAGPGVYICDECIELCSEIIEDEFEGNTESSPLEASNLPKPQEIKDYLDQYVVGQDRAKKSLAVAVYNHYKRINANKAEDDVELQKSNILLLGPTGSGKTLLAQTLAKMLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDVERAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQINTSNILFICGGAFDGIDKIIEKRGTKSSIGFGAEVKGKSEKNVGELLKDIMPGDLLKFGLIPEFVGRLPVLVTLEALDNEALVSILTKPKNALVKQYKKLFELDNVKLDFTEEALKAIADEAINRKTGARGLRAIVEETMMDIMFDIPSEENIVKATITEETIKDRKDPELEKLPEGEVRPTLKTEKKNKARKDIETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL19_ACIBC
Sequence: MSGKHPLVQAIENSQLKTDLPEFAPGDTVVVQVKVKEGDRERLQAFEGVVIAKKNRGLNSAFTVRKISSGVGVERVFQTHSPVVAKIEVKRRGDVRRAKLYYLRDLSGKAARIREKLPARKA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MUTS_SORC5
Sequence: MQPSEQPAARKKLTPVMRQYEDAKALHPDAILFFRMGDFYEMFNDDAVLVSRALNLTLTSRNKGEPDESPMAGVPHHAAHGYIARLLALGHKVAICEQCGDPSKIKGLVPRQVVRVVTPGLVTETEQLDARANHYLAAVDGGGAPRGDALGAGGPYGLSLLDLSTGELSATSVPDAATLLAELARADPREALIARDLPDVRAAAASLACRAALRDDEELDSAHVASILDDAAIEPISAAALAEHPLPAVRAAARALRFARRCSPGARIPVRRIAPHDTSGTLRIDETAQAHLELVRAADGGRRGTLLDVIDCTVTPGGARLLRRRLLSPLADLAGIRRRLDEVELFVSHPRARGELRQALGGVGDLERLSVRALLGEATPRDLGLLRDGLTAAPAAIAAVRSIPDLGKAAARSDDGAAARGKDGAAAGSSSGSEPLLAEAAALDVVADVCAELTAALIERPPPNTREGGIFREGYDKELDDARGVEKNATELILALEAKLRTQTGAPSLRVKYTRVFGWYIEVTRAHIAKVPETFRRKQTVATGERYTSDELDELADKIEHAGARALERETALFDRLRALVAKSEGRLRALARKLAAWDVAAALADVAHRNDYVRPHVTAGEALAIRDGRHPVVERYAAAGHFVPNDTRLDLSGERLWLITGPNMAGKSTLMRQVALIVVLAQMGSYVPAREAEIGLVDRILSRVGASDNVARGESTFMVEMRETAEILRDATRRSLVILDEIGRGTSTYDGLAIAWAVAEHLFDAIGCRALFATHYHELTELSARAPGIANYSVAAREHGDDVIFLHKLEAGPASRSYGVAVARLAGVPEGVLARARAILATLESGAALPGGKHASLRGRTRGGAAQLDLFAPAQAAVPPEQSAVIETLRAVDVDRLAPLDALRLVAKLKGLLGGGG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: S2538_VANPO
Sequence: MANTTKTRTHLIGGFFGGLTSAVALQPLDLLKTRIQQHQSQSIWSIVKNSKGFSELWRGTLPSAIRTSLGSALYLSSLNLMRTAIAKSKTNYNDGASKSSLLPKLTTYENLISGALARGAVGYMTMPVTVIKVRYESTLYSYTSLSQAVKHIYQSERIPGFFRGFGPTLVRDAPYSGIYVLLYEKAKEVVPKLLPRKFIKFDKHGSYLTSTSTLVNSTSAILSACLATTITAPFDTIKTRMQLEPKRYTNVWFTFKSIIKNEGILKLFSGLSMRLTRKALSAGIAWGIYEELIKLNKF
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL35_RICRS
Sequence: MPKLKTKSAVKKRFKLTASGKVIASQAGKKHFMRRRTKAQIRNLRGTTILCPQDGYNIKKYFLPYGIN
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ERLEC_XENLA
Sequence: MRRSDRFPCAGASLLVVLCGVFPSSFGGRTLPGLSDDIPFRLKWPGPDFTLPTAGIPYKEENYIIMTTADQETYKCMLPLMANGNEEEDREYKGPSPGELLDPLFKLSSCSYRIESYWTYEVCHGKYIRQYHEEKEAGQKLNIQEYYLGKTVKKSPSEAGENQEDKERTEGHKDIHTKNIEGQMTPYYPVEMTNGTPCSLKQNQARSSTVMYICHPEAKHEILSVAEITTCEYEVVILTPLLCNHPKYKFRPSPINDIFCQSMPGSPLRPQSLEKLEHQQEEIKSPLKAKEEEQQLLKEKFSTIHKPVTVGSQQQVTVGTTHISRLTDEQLIKEFLSGSYCFHGGVGWWKYEFCYGKYVHQYHEDKDTGKTTVVVGTWKAEEHLDWAKKNLAKAYMSTADGVQTVKTVSHFYGGGDLCEVNEQPRQVVVKLKCKQSESPHAVTVYMLEPQTCQYILGVESPVICKILDTADENGLLSIPN
What is the function of this protein?
Probable lectin that binds selectively to improperly folded lumenal proteins.  May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity).
What are the official names of this protein?
Endoplasmic reticulum lectin 1, ER lectin, Erlectin.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.