PharMolix/UniProtQA huggingface dataset:
Protein: GLGB_YERPA
Sequence: MSVLPDRQVINQLISGHYGDPFSILGMHETSQGLQICALLPDAREVWLVETENGRRIAQLTLEDPRGFFIAQLTRRKKSFRYQFAVTWQENPQIIEDPYRFGPLLQDIDSWLLAEGTHLRPYERLGAHLMSLDGVSGVSFAVWAPNAQRVSVVGDFNFWDGRRHPMRLRRENGIWELFLPGIEAGQLYKFEIIDCHGQVRLKADPYAFEAQMRPETASLISPLPDVVKSSAARQKANDLCSPVSIYEVHLGSWRRHTDNNFWLSYRELADQLVEYVKYMGFTHVELLPINEHPFDGSWGYQPLGLYAPTRRYGTPEDFKAFVAKFHQAGINVILDWVPGHFPSDEHGLSTFDGTALYEYADPREGYHQDWNTLIYNYGRNEVRNYLAGNAFYWMERFGIDALRIDAVASMIYRDYSRAEGQWVPNYYGGRENLEAIAFLRYTNKTIGVERPGSVTMAEESTDFPGVTLPPDIGGLGFNYKWNMGWMHDTLNYMQCDPVHRKYHHNLMTFGMLYAYTENFILPLSHDEVVHGKRSILDRMPGDAWQKFANLRAYYAFMWAHPGKKLLFMGCEFAQGREWNFETSLDWHLLDDENGWHSGVQRLVRDLNHCYRQYAPLYEWDYQPAGFEWLVVDDHENSVFAFLRRDAEGHELIAISNFTPVPRYHYRVGIPQGGHYREVLNSDSAFYCGSNLGNQGGIDSHHVRSHNHEHSLLLTLPPLATIYLLREN
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: K1C18_HUMAN
Sequence: MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH
What is the function of this protein?
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity).  When phosphorylated, plays a role in filament reorganization.  Involved in the delivery of mutated CFTR to the plasma membrane.  Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
What are the official names of this protein?
Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Nucleus matrix. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm.
Protein: DLD1_KLULA
Sequence: MFRFVGRSGFALRGSLQLRKDVLRSRTTAVAKRHYSSSNGNNGGGFSSAILSVLGGSLIGGGFVAYALGSQFEKEKSVSDLSIARLEDLDSPEYCDKETFAKALVELKDVLENDPENFTVAKDDLDAHSDTYFNSHHAEANQRPEIVLYPRNTEDVSKLLKICHKYSIPVIPFSGGTSLEGHFLPTRPGSCVVLDISKYLNKIIQLNKEDLDVVVQGGVPWEELNEYLNDHGLLFGCDPGPGAQIAGCIANSCSGTNAYRYGTMKENVVNITMCMADGTIVKTKRRPRKSSAGYNLNGLIIGSEGTLGIVTEATIKCHVRSTFETVAVVPFPTVSDAASCSSHLIQAGIQLNAMELLDDNMMKIINQSGATSKDNWVESPTLFFKIGGRSEQIIQEVIKEVEKIASQHNNTKFEFATDEDSKLELWEARKVALWSTIDTGRKTNPDANIWTTDVAVPISKFADVINATKEEMNASGLLTSLVGHAGDGNFHAFIIYNTEQRKTAETIVENMVKRAIDAEGTCTGEHGVGIGKRDYLLEEVGEDTVAVMRKLKLALDPKRILNPDKIFKIDPNDHQH
What is the function of this protein?
Catalyzes the stereospecific oxidation of D-lactate to pyruvate.
What are the official names of this protein?
D-lactate dehydrogenase [cytochrome], mitochondrial, D-lactate ferricytochrome C oxidoreductase, D-LCR.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MBHT_ECO57
Sequence: MTGDNTLIHSHGINRRDFMKLCAALAATMGLSSKAAAEMAESVTNPQRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLEYHEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKDNGIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAAAGVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHIITYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAKEFGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWPVAIGHPCYGCNEEGIGFHKGIHQLANVENQTPRSQKPDVNAKEGGNVSAGAIGLLGGVVGLVAGVSVMAVRELGRQQKKDNADSRGE
What is the function of this protein?
This is one of three E. coli hydrogenases synthesized in response to different physiological conditions.  HYD2 is involved in hydrogen uptake.
What are the official names of this protein?
Hydrogenase-2 small chain, HYD2, Membrane-bound hydrogenase 2 small subunit, NiFe hydrogenase.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Periplasmic side. Periplasm.
Protein: JANB_DROYA
Sequence: MKMFKSLSQLPRIVSPFQKCYSTDLISLVGIPRVKITKGQNRYLLVNIHTHGFTKYGRVIVRGADVDNHLTVFDSILEELEPQGICAKILGGGRILNEADSKKMKIYGTSRTFGSADHTRTRNILHSWTTYKDFKITVKN
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-B.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: THAB_PAROL
Sequence: MAQWPEKEEEEQPMFGEEYTGYIPSYLEKDEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDCCCIIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRRLIEENRERRKKEEIVKTLQNRPEPTGAEWELIRMVTEAHRHTNAQGAQWKQKRKFLPDKIGQSPVAPTSDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSEQLPCEDQIILLKGCCMEIMSLRAAMRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLAQFNLDDTEVALLQAVLLMSSDRSGLTCMDKIEKCQETYLLAFEHYINYRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPNELFPPLFLEVFEDQEV
What is the function of this protein?
High affinity receptor for triiodothyronine.
What are the official names of this protein?
Thyroid hormone receptor alpha-B, THR-alpha-B, Nuclear receptor subfamily 1 group A member 1-B.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPH_ECOL5
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRNETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFTCYAREQVMTILPDSPPRFINLNNYLWSERWLVRYRDMDFIQSVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMEQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: SYE_PROM4
Sequence: MAIKVRLAPSPTGKLHIGTARTALFNWLFARKNNGSFLIRIEDTDKERSQEEYKENILEGLDWLGLTWDAEPIIQSNRIEQHREAIKYLLEKGLAYRCFTTEEELAAMREEQKSRNKPPRYDNRHRSLSTEEESNFLSEGRTAVIRFRIDDNESIQWNDLVRGPMNWTGKDLGGDMVIARRAPANEIGDPLYNLVVVIDDGYMGITHVIRGEDHIANTAKQILLYKALGLTLPKFAHTPLILNAEGKKLSKRDGVTSISDFKEMGYTSKAMSNYMTLLGWSIPDGMDEKFTIEESSKVFDFDRVNKAGAKFDWEKLKWLNSQTIHDSSSEEILKAVEPLFNKEGWDLPNLEWSLKLIELIKPSMTLLTDSVEQSRFFFEDPLLNQDAINQLEIEGAKDSLKILLKQIDTSKINKLTVEHAKKLINDAAVFGGFKKGLIMKSLRAALLGCLQGPDVINSWILLSEINQDKSRIERCL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDH_ECOL5
Sequence: MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCP2_YEAS7
Sequence: MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFHFEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSNIKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNMLHTAVQANSNNNAVSNGQVPSSQEHQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLSEPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPVPPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSKKPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKTHASKPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERTSLNVDIGVNVMPSEKDSRRSQKEKPRSDANKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDSDAYEVFESSSDEEDGKKLEELEQTQGNSKLISQDILKENNFQDGEVPHRDMPTESNKSINETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNPISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGMLKQKEKDITAPKQPYNVDSYSQKNPAKGLLNILKKNNSTGYPRTEGGPSSEMPTSMKRNDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSTFNNNVYATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK
What is the function of this protein?
Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.  Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.  Decapping is the major pathway of mRNA degradation in yeast.  It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
What are the official names of this protein?
mRNA-decapping enzyme subunit 2, Protein PSU1.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DCP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: NADA_TRIEI
Sequence: MFATQTRINQNFNSIPDDLFEAIADLKKELNAVILAHYYQEPDIQDIADYIGDSLGLSQKAAETDADVIVFAGVHFMAETAKILNPNKLVLLPDLDAGCSLADSCPPEEFGKFKAAHPDAIVVSYINCTAAIKAMSDIICTSSNSVKIVKQIPTDQPIIFAPDKNLGRYVMEQTGRDLILWSGSCIVHETFSEKKIVQLKIEHPEAEIIAHPECEPNLLRHANYIGSTTALLKYCQESQEQEFIVATEPGIIHQMQKREPKKNFIPAPAMNNCACNECPHMRLNNLEKLYLAMKNKTPEIMIPEETRVAALKPIQKMLELSFT
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMX1_HUMAN
Sequence: MCLAGCTPRKAAAPGRGALPRARLPRTAPAAATMFQPAAKRGFTIESLVAKDGGTGGGTGGGGAGSHLLAAAASEEPLRPTALNYPHPSAAEAAFVSGFPAAAAAGAGRSLYGGPELVFPEAMNHPALTVHPAHQLGASPLQPPHSFFGAQHRDPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVKVWFQNRRTKYKRQKLEEEGPESEQKKKGSHHINRWRIATKQANGEDIDVTSND
What is the function of this protein?
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain.  May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
What are the official names of this protein?
Homeobox protein EMX1, Empty spiracles homolog 1, Empty spiracles-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the EMX homeobox family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Might be shuttling between the nucleus and the cytoplasm.
Protein: TYSY_CLOB8
Sequence: MSLYDDKYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWIFKDQSNSVKELQSQNVKIWDEWMMEDGTIGTSYGWIVKKFDQIDKLIDALKNNPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQYAVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKNDAYNAPKLWINPEITNFYDFTPDDIKLEDYKHHESIKMDVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HETQ2_PODAS
Sequence: MSAISHHSLSHLNSTVSKRLMPTYSDPVVRIAVLDTGFDGSHPDFSHPRTAYFTGPFSDLPQPEKDEEPQLTRIKAYHDFCQPSPPGDRQGPPPQPHSMVDLAGHGTAIAGLILRLAPRAELVIGRVCHGVDSNELSAPDPSRVAAAIRWAITQKVHIINLSLGYRNQPLKELLPLRAALLEAQRSNILVFASTSNQGSHEPAAWPASDARFAIGVHSCNDMGSAPSGSSCKASENGYNFMAVGENLLVHRLAQKGGGFELVSGSSFATPVVVSVAALVLAFVWQEECKRERDEVGREVMLEDLGSLGGMGRVLMALGEKTAGSYWAVGMKLFWAGYREGDGRDPEKEEKEARRWAWGVLRGAVAY
What is the function of this protein?
Serine protease involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition) (PubMed:35135876).  In P. anserina, the het-q locus exists as 2 incompatible alleles, het-Q1 (AC B2AXJ5) and het-Q2 (this entry) (PubMed:35135876).  Prevents cell fusion with strains containing the gasdermin-like protein het-Q1 by mediating proteolytic cleavage and maturation of het-Q1 during the allorecognition process, thereby triggering cell death (PubMed:35135876).
What are the official names of this protein?
Subtilisin-like protease het-Q2, Heterokaryon incompatibility protein Q2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LOLA_LEPCP
Sequence: MSSARRRALGFSFQALLLCAAGWHGAAQADGVSALRDFVQNVQSGRATFNQTVTSPDGAKKKTSTGSFEFLRPNRFRFDYTKPYEQQIVADGVKVWLHDVDLNQVTVRPFDQALGSTPAALLAGASIERDFTLANLPEEAGLQWVQALPKAREGSIRSLRVAFRGKDLAAFEITDAFGQRSRLDFNRFEGNAAVPAARFKFVAPAGADVLQQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GCSPA_DESDA
Sequence: MPYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAKNCPDLVSFLGAGYYAHDIPKAVDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRLLGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVNPIWRVMLASYISSLDLELKTVQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVMQSVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGKTGYVLTLQAREQHIRRAKATSNICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYAVERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAHGCVPGYPLGRYYPGMEDVLLLACTERNSRQQIGMLAETVGGLL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: RLMH_CLOBL
Sequence: MNISIISVGKIKEKFLKAAIDEYSKRLSKYCKLNIIEVTDEKTPDNASLKEENIIKDKEGNLILKHIKDNSFVIALDLKGKSITSEEFSGLIENCRLTGNSTIAFVIGGSLGLSEQVLSRANYKLSFSKMTFPHQLFRVMLLEQVYRAFRILCGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA1AB_CONAN
Sequence: GGCCSHPACAANNQDYC
What is the function of this protein?
This synthetic toxin blocks rat alpha-3-beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0. 2 nM).
What are the official names of this protein?
Alpha-conotoxin AnIB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
Protein: A1L_LOXAP
Sequence: WIMGHMVNANYQIDEFVNLGANSIETDVSFDSSANPEYTYHGVPCDCRRWCKKWEYFNNFLKALRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQAYDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPNLAHYKLITGFKETLKTEGHPELMEKVGYDFSGNDDIGDVANAYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSNGYINKVYYWTVDKRQSTRDALDAGVDGIMTNYPDVIADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LapSicTox-alphaIB2, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DTD_MYCBP
Sequence: MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLAGEKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_JANSC
Sequence: MSCPYPFKVFSCTVSRHSHQAACVVAKTQATSQPRGALSPGGGFLAALALSVTGWRIGSKGHIVAQKTSTPPPDTIQAGDMITDFDQYLLGEGTHRQLWRVLGAHVQDDATHFAVWAPNARAVSVTGDFNGWSGTEMTAVGQTGVWQVRIPGVGDGALYKYQITDANGALREKADPVGFGAQHPPEQASVVRDIRGYGWRDGAWMETRAEAADRAAPISIYEVHLGSWRRKWDDGGRPLSYKEAAQDLVGYVRHMGFTHIELMPISEFPFDGSWGYQPVGLYAPTIRFGPPHEFRDLVDAAHAAGLGVLLDWVPGHFPTDEHGLATFDGTHLYEHADPKEGFHQDWNTLIFNYGRTEVRNYLVANALYWMEEYHLDGLRVDAVASMLYRDYSRDEGQWVPNKDGGRENLEAISFLQEMNVAVYGADASVMTVAEESTSFPGVSQPVHTGGLGFGYKWNMGWMNDTLSYMALDPIHRQHHHSQMTNPIMWQYSENFILPISHDEVVHGKGSMLEKMPGNDWEKLANLRAYYGYMWMHPGKKLIFMGCEFAQPGEWSHDGDLNWDAASRPAHAGVQALVRDLNHLYRDTPALHVKDCMPDGFAWICNDPAQSTLGFARFGAAGDAPVVVMCNFTPVERVAFRMGVPTPGEWDEVLNTDAAAYGGGNRGNLGGVLSEPTPCDGHAQSVTLTLPPLSTVVLRLKD
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: ATPA_LACDB
Sequence: MSIKAEEISSLIKQQLEHYDDKLDIEEVGVVTYVGDGIARAHGLNNVLSSELLQFDNGAYGIAQNLESNDVGIIILGKFDDIREGDRVKRTGRIMEVPVGDALIGRVVNPLGQPVDGLGEIKTDKTRPIESKAPGVMQRQSVNQPLQTGIKAIDALVPIGRGQRELVIGDRKTGKTSLAIDTILNQKGQDVICIYVSIGQKESTVRAQVETLKKLGAMDYTIVVEAGPSEPAPMLYIAPYSGIAMGEEFMYAGKDVLVVFDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERSAKLSKELGGGSLTALPVIQTEAGDISAYIPTNVISITDGQIFLQSDMFFSGTRPAIDAGASVSRVGGAAQIPAMKKVAGTLRTDLASYRELESFAQFGSDLDQATQAKLARGRRTVEVLKQPLHKPVAVEKQVVLLYALTHGFMDAVSVDDIARFEQELYTDFDANHADLLAEIKSTGKLPDENKLQEALQQFASSFSSSNK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURB_TROWT
Sequence: MVSFSEITTLGVGGSIACFIECSPDEFVERAPGLFRPGHHVLVVGGGSNLVASDCPFPGTVVRLKSRDTIVSDDGDYTRFSISAGTSWDDLVSYSLDLGFDQLSPMSGIPGTFGGALAQNISAYGAAVRDVLGSVEVYDACTSEVVTFGLEDMRYGYRTSALKNVRNKVILGGTLLLKPGPTPVLHRQLANALKVDLGTYCSGKQVRDQVLRIRAEKGMLPRYLVPKGFDVCNTSSVGSFFVNPIVSKEHLSRLRRLVPQGALNSSVIQTDEMGGVKVSAAFLLEQSGFEKGFCISGSQAAISTQHSLAIVNRGGATAAEVIELAGLITRTVSRKFDIHLIPEPVFVGLEL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_CLONN
Sequence: MKITVEDIIKDLELEVLVQGEKDKEIKTSDINRPGLQFAGFYSYFANSRVQVIGNAEWSFLKNMPVELIRKRMKKFFEFDTPCIIIARDLEPHPQLIKNAKLHKRWVLRSKLLTTKVVTKLMNYLDAKLAPETRMHGVLVDVYGIGMLITGESGIGKSETALELIKRGHRLVADDAVDIKEIDGVLRGTSPYITSGMLEVRGMGIIDIPALYGLSSVLQKKTIHLVIYLEQWKPDRNYDRLGIDDDFLEILNVPVKKLTVPIRPGRNLAVIIEAAAANYRYGLMCKVSPVETINNRMESMVRNESKR
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.