PharMolix/UniProtQA huggingface dataset:
Protein: ADRB2_MACMU
Sequence: MGQPGNGSAFLLAPNGSHAPDHDVTQERDEAWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHAQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKACGNGYSSNSNGNTGEQSGYHLEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRSCSTNDSLL
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
What are the official names of this protein?
Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane. Activated receptors are internalized into endosomes prior to their degradation in lysosomes. Activated receptors are also detected within the Golgi apparatus.
Protein: TYLE_STRFR
Sequence: MAVQKEATLVRQIIRAAGGHAADVRELVAEHGPEAVTAVLVDEIVSRAPHPVNDVPVLVELAVRSGDALVPRRLAVAQGAPVRRAAPDDDGFVAMRVEYELDELVRELFGPCRERAAGTRGTTLFPYATSGTGHIDTYFLAAQQATATVLAGCTSAKPDLNELTSRYLTPKWGSLHWFTPHYDRHFREYRNEEVRVLEIGIGGYQHPEWGGGSLRMWKHFFHRGLIYGLDIEDKSHAEEQRITTVVGDQNDPGCLTELAARYGPFDIVIDDGSHINEHVRTSFHALFPHVRPGGLYVIEDLWTAYWPGFGGDSDPGKSDLTSLGLVKSLVDSLQHQELPEDSGRSPGYADRHVVGLHVYHNLAFIEKGVNSEGGIPGWIPRDFDALVAASSGGAA
What is the function of this protein?
O-methyltransferase that catalyzes the conversion of demethylmacrocin to macrocin, the penultimate step of tylosin antibiotic biosynthesis.  Also able to mediate the conversion of demethyllactenocin to lactenocin.
What are the official names of this protein?
Demethylmacrocin O-methyltransferase, Tylosin biosynthesis protein E.
Protein: APOC1_URSMA
Sequence: MRLFLSLPVWVAVLAMVLEGPAPAQAAPEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTRNWFSETFNKVKEQLKTAFS
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRAF2_MOUSE
Sequence: MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCPKFPLTCDGCGKKKIPRETFQDHVRACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
What is the function of this protein?
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis.  Required for normal antibody isotype switching from IgM to IgG.  Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1.  Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases.  Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.  Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity.  Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.  In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
What are the official names of this protein?
TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, RING-type E3 ubiquitin transferase TRAF2.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_PECAS
Sequence: MKDLSIRIAVVGAGGRMGRQLIQAIEQMDGVVLGAALERSGSSLLGSDAGELAGLGKNGITVNESLDAVQNDFDILIDFTRPEGTLAHLAFCRLHRKGMIIGTTGFDDAGKAAIKQAAQDIGIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEVIADALGRDLKSCAVYTREGHTGERDPKSIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGAVRAAIWISSKESGIFDMRDVLSLDDL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BROMI_MOUSE
Sequence: MAHFSSEDEVMLQAMLRQLFQSVKEKITGAPSLECAEEILLRLEETDENFHNYEFVKYLRQHICNMLGSMIEEEMEKCTSDQNQGEDSGYDTVVQHVTKRTQESKEYKEMMHSLKNIMMVVVEAMINKFEEDETRSEDRQRKMQSGSCCTDNCSDSDSSFNQSYKFCQGKLRLILDQLDPGQPKEVRYEALQTLCSAPPSDVLSCENWTTLCEKLTTSLSDPDPMFTDRILKFYAQTFTLSPLHMTKEIYTSLAKYLEVYFLSRENHLPTLSTGVDITSPNVTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLSVKHEQSHLVPQKILDPIYFFALVDTKAVWFKKWMHAYYSRTAVLRLLEKKYKCLITTAVQQCVQYLELCEAMKADEILRHPKHCGTKQKSFYYSGQELQYIYFIHSLCLLGRLLIYTQGRKLFPIKLKNRKDSVSLTNLLVLFTQLIYYSPSCPKMTSIMCSENYSPASMVTDVLRMLCDQKECAVECLYNSTVTEALLLPIHNLTKGTAAAPDCSETALIHIADILARIASVEEGLILLLYGENMNSSEEESLTGAHIIAKFSKKLLEEDISIFSGSEMLPVVKGAFISVCRQIYGTCEGLQVLLPYGLHESIAKAWKKTSLLSERIPTPVEGSDSVSSVSQVSPNSVAWEDNLLDDLLNFAATPKGLLLLQRTGAINECVTFMLSQYAKKPQVNRQKKFGYEVLVVQVASTAAGAVALQNSGFISALITELWSNLECGRDDVRLTHPRATPVDPIDRSCQKSFLALVNLLSYPAVYELTANQELPNKAEYSLREVPTCIIDIMDRLIVLNSEAKIRSLLNYEQSHTFGLRLLSVVCCDLDALLLLEAQYQVSNMLLHAQEENTFEISENHRNFIIDGLSVERNHVLVRINLIGGPSERILPPRMLEKGDDPYPWPMFSSYPLPHCYQSEGPRSADLKQDNDIGNLLSCFKMSDKQTEWIENCRRQFCKTMKSKPDAVHGSALGELLEKFVLLLTENPSECYFPSVEYTATDANVKNESLSSVQQLGMKMTVRYGRFLNLLKDGAENELALVLKHCEKFLKQQQSPVTSSLLCLQGNYAGHDWFVSSLFMIMLGDKGKTFHFLQHFSRLLTSAFLWVPRLHNSRYLPVDTLGTGIHPIYFCSAHYIEMLLKAEVPLVFSAFHMSGFAPSQICLQWITQCFWNYLDWIEICHYIATCVVLGPDYQVYVCIAVLKHLQRDILQHTQTQDLQVFLKEEALHGFRVSNYFEYMENLEQNYRPVLLRDMRSIRVQNT
What is the function of this protein?
Required for high-level Shh responses in the developing neural tube.  Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling.
What are the official names of this protein?
Protein broad-minded, TBC1 domain family member 32.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium.
Protein: ISPG_XYLFT
Sequence: MTPQVASDSAVPWPRRLTQAVNIGHLTVGGGHPVVVQSMTNTDTADVVASTKQVAELWRAGSEMVRLTVNNAQSAAAIPRIAERLAMMGIEVPLIGDFHYNGHQLLADEPACAEVLAKYRINPGNVGFGKKRDLQFGQLIECAIRYGKPIRIGANWGSLDQMLAAQLMDENNRRKQPWDAAQVLREVLIFSAVGSAERAVELGLPRDRIVLSAKVSGVQELIAVYRDMAARCDFALHLGLTEAGIGSKGIVASSAALAVLLQEGIGDTIRISLTPEPGQSRTQEVIVAQELLQTTGHRAFTPMVTACPGCGRTTSEFFQELAKTVQQHVRDKMQVWKITHPGAETMTLAVMGCVVNGPGESRHANIGISLPGTGEMPVAPVFIDGEKSVTLRGGNIAQDFITLVDDYVERRYARFPD
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: COXX_ROSCS
Sequence: MRRENARVVALPLFRTSWMVIALALVAYGAILAGSIIPTMTGAAVSSIATAVLGGALAMYTGMRTRAAPVRLGGRATAARRSYLTLAFAAVGMLYLAVVAGALNTSAGTLWTCQTWPGCEASGSGDWPALAHRGLAGVATILIAALAMQTWRIRHERALRVAVACALGLMLVQNIVGLVQVLLAQAGESLPLAVARLTHLGLSATAWGALVVLVTLALRRPFPSVVAAPSPATVARPGLTDTTLLEGKPSLLKDYVSLTKPGVISLLILTTITSMYITPAGIPEWSLVLWTTIGGWLMASGSHSINCYLDKDIDINMGRTSRRPIPSGRIPAWHALALGVVLGMIAFAILAIFVNMLTALLALAGFFYYVVIYTIWLKRTSKHNIVIGGGAGAFPPLVGWAAVTGSLAPEALLLWLIVFFWTPPHFWALALIREKDYARAGVPMLPVVAGDVETRRQIVLYTLSMLALTALPPLLGMLGWSYLLMASIFGGLFLYYALKLRRDGTTATAWALYKYSLLYLALLFVAMVVDRAVFA
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YO002_HUMAN
Sequence: MAGVRARAPLPLALLLSLPAAPGGRDPSASRARFPQRLGRAPCFEVGLRKPPPPPLLSPPSFSSGSSRPLQRPRGPKDGAGRKVCAKLVKRLPGESGSCEDGQSAPAQPPRRRTGTRACPPRAPLWR
What are the official names of this protein?
Putative uncharacterized protein UNQ6190/PRO20217.
What are the subcellular locations of this protein?
Secreted.
Protein: ZAPA_YERPG
Sequence: MSAQPVDIQVFGRSLRVNCPPEQQDALNMAAEDLSQRLQDLKVRTRVNNTEQLVFIAALNVCHELAQERLKTRDYASNMEQRIRMLQQTIEQALLEQGRISDRQDTQFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: MAZE_STAAE
Sequence: MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity.
What are the official names of this protein?
Antitoxin MazE.
What is the protein family that this protein belongs to?
Belongs to the MazE/EndoAI family.
Protein: PANC_STAAT
Sequence: MTKLITTVKEMQHIVKAAKRSGTTIGFIPTMGALHDGHLTMVRESVSTNDITIVSVFVNPLQFGPNEDFDAYPRQIDKDLELVSEVGADIVFHPAVEDMYPGELGIDVKVGPLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGKKDAQQLAIVEQMVKDFNHAVEIIGIDIVREADGLAKSSRNVYLTEQERQEAVHLSKSLLLAQALYQDGERQSKVIIDRVTEYLESHISGRIEEVAVYSYPQLVEQHEITGRIFISLAVKFSKARLIDNIIIGAE
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIGE_ECOLI
Sequence: MAHQLLIGKGMITLNLKRIFLALTLLPLFAVAADDCALSDPTLTVQAYTVNPQTERVKMYWQKANGEAWGTLHALLADINSQGQVQMAMNGGIYDESYAPLGLYIENGQQKVALNLASGEGNFFIRPGGVFYVAGDKVGIVRLDAFKTSKEIQFAVQSGPMLMENGVINPRIHPNVASSKIRNGVGINKHGNAVFLLSQQATNFYDFACYAKAKLNVEQLLYLDGTISHMYMKGGAIPWQRYPFVTMISVERKG
What are the official names of this protein?
Uncharacterized protein YigE.
Protein: SPT16_HUMAN
Sequence: MDAGSSRSLENAVNRIYHDQLVPKINTSKKMSTLAHPPNILEMSQEIKKNCGGKQVEITLERTKMTKGIKEKQSNDLEKAAFKRKAEGEEKPTRKKQAKITELDNQLITMPLPHIPLKNIMDVEMKLVYIDEMGVRYEFVESFMSTGSQPTCQAAEIVDPLSVHNFSFLPQIDKWLQVALKDASSCYRQKKYALAAGQFRTALELCSKGAVLGEPFDAPAEDIASVASFIETKLVTCYLRMRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLGGGREESISKLIKLYWQAMIEEAITRAESFSVMYTPFATKIRADKIEKVKDAFTKTHPAYAEYMYTDLQALHMLPQTVDWSSFPPQQYLLTLGFKNKDDGKFLEKISSRKLPIFTEHKTPFGLTREDTVRQMETMGKRILPILDFIRSTQLNGSFPASSGVMEKLQYASLLSQLQRVKEQSQVINQAMAELATIPYLQDISQQEAELLQSLMADAMDTLEGRRNNNERVWNMIQKVGQIEDFLYQLEDSFLKTKKLRTARRQKTKMKRLQTVQQR
What is the function of this protein?
Essential for spermiogenesis and male fertility (By similarity).  Involved in the formation of sperm acrosome during spermatogenesis.
What are the official names of this protein?
Spermatogenesis-associated protein 16, Testis development protein NYD-SP12.
What is the protein family that this protein belongs to?
Belongs to the SPATA16 family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Shift from Golgi to sperm acrosome.
Protein: PDM2B_DROME
Sequence: MPLLLATTLANNSHHQHLSTTATETAAAAATAKAAATAAAAATATMLLTSPTAATHCLAAATSAAGVNVQITGQGVSATLNDDQLQLPANYAANVGHLNGFNPKDNCPPVPPTSERAFEGLLRLPQIQVKQEFMESPPERPSCHPMNHQQAPANSALATSCRGKTILNPWYLRPADGIGYHNYNSNNNNSGSGEINKDVSQQMTSACGGSDGQTCLPVSYFGMETLASVKQRQKSLPDFLIPLHEIMFQQQHHYQQRTMGTLINSLPPGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIPQNHTGDHSFVRHFHERDRLIREHQLKHQQLRDVEEVLQEQEQDEEQEHETLRKPHVVPSELEHNHHWHGVVCDANGHATRLLHIAPPRAGPTPLPTHQQPPVGEVLPPNSTSFSTIVDPPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTGTPLSSHAFGYPPQALNMSHMQMEGGSGSFCGSSISSGE
What is the function of this protein?
DNA-binding regulatory protein implicated in early development.  Involved in neuronal cell fate decision.  May act as an octamer-dependent activator of transcription.  Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
What are the official names of this protein?
POU domain protein 2, isoform B, Miti-mere, Pdm-2, Protein didymous, dOct2, dPOU-28.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_LACPL
Sequence: MANTREFSLDKTRNIGIMAHIDAGKTTTTERILYYTGKIHKIGETHDGASQMDWMAQEQERGITITSAATTAQWKNHRINIIDTPGHVDFTVEVERSLRVLDGAIAVLDAQSGVEPQTETVWRQASTYNVPRIVFVNKMDKIGADFKYSVSTIHDRLQANAHAIQLPIGAEDNFEGVIDLIEMKADLYDEDQLGTEWDTVDVPDEYKEEAQAARDDLIEALADIDDGIMEKYLGGEEISKEEIKAAIRKGTLALEFFPVLAGSAFKNKGVQMLMDAVVDYLPSPLDVKPYKATDPETEEEVDLIAGDDKPFAALAFKVATDPFVGRLTFIRVYQGTLESGSYVLNATKDKRERVGRLLQMHSNQRKEIPEVFSGDIAAAIGLKNTTTGDSLTSIEHPYHLESMEFPDPVIQVAVEPKTKADQDKMNVALQKLSEEDPTFKAETNPETGETLIAGMGELHLDIIVDRMRREFNVEATVGAPQVSYRETFTKSTQVQGKFVHQSGGKGQYGDVWVEFTPNEEGKGFEFEDAIVGGVVPREYIPSVEQGLKEAMANGVLAGYPLVDVKAKLYDGSYHDVDSSEAAFKIAASLALRNAVKTAGPVILEPIMKVDIVAPEDYLGDVMGHVTARRGNIEGMEERGNAQEVHAYVPLAEMFGYATTLRSATQGRGTFTMTFDHYEKVPKSVQEDIIKKNGGTPAK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPTC4_RAT
Sequence: MSVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALKVTLKQDTHGVGHDPAKEFTDHWWSDLFNKTAANLVVDSGKDGVQIRRLSKETTQRSHSKPSLLYQKFVKTATLTSGEEKPDRDLESCSDVDNREPIPPKILTDEMLLKACEGRTAHKAARIGITMKAKLARLEAQEQAFLARLKGSKDVGTSQPLTDSEPSQKKKKRRKQKEEEEAATTEKSLGEELLEHTDKSFRKSKKKKKKKKDEREGTAIGSEEEEAAGVCGPAELSTEQSDQSSRKKKKRRRRHHEEEEEMGVCDEGGRDVTGGPKAVNSGADTDPWRSSKKRQTCEEDLDTQDEEDKDDLTKKERKVRKKDKKKRQQYCEEVLDVSNKDDGRTWEAEDGGERSQPHPKARAKKKKRKTD
What are the official names of this protein?
G patch domain-containing protein 4.
Protein: TGT_PSEAB
Sequence: MNFELLATDGKARRGRLTFPRGVVETPAFMPVGTYGTVKGMLPRDIEDIGAQIILGNTFHLWLRPGTEVIQRHGDLHDFMQWKGPILTDSGGFQVFSLGAMRKIKEEGVTFASPVDGAKVFMGPEESMAVQRALGSDIVMIFDECTPYPADHDVAKRSMELSLRWAKRSKIAHGDSPSALFGIVQGGMHEDLRLRSLDGLQEIGFDGLAIGGLSVGEPKEEMIRVLDFLPPQMPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFVDSGVIKIRNSVHKHDDSTLDPTCDCYTCKHFSRAYLHHLDKCGEMLGSMLNTIHNLRHYQRVMAGLREAIQQGTLAAFVDAFYAKRGLPTPPLDA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: HIS3_MAGMM
Sequence: MEKLPDLATLKYNEQGLIPAIAQQYDTGEVLMMAWMNQTSLAETLSTGVACYWSRSRNRFWRKGESSGQVQTVKAVRLDCDKDTLLLLVDQQGVACHTGRHNCFYLEAQDGSWKTITDPEIDPEELYGK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCC1_STAA8
Sequence: MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHNQGPAFPFAECGAMSQAYIGYQLQESLQNELHSIGMDKQVVTLVTQVEVDENDPAFNNPSKPIGLFYNKEEAEQIQKEKGFIFVEDAGRGYRRVVPSPQPISIIELESIKTLIKNDTLVIAAGGGGIPVIREQHDGFKGIDAVIDKDKTSALLGANIQCDQLIILTAIDYVYINFNTENQQPLKTTNVDELKRYIDENQFAKGSMLPKIEAAISFIENNPKGSVLITSLNELDAALEGKVGTVIKK
What are the official names of this protein?
Carbamate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4P1_MOUSE
Sequence: MAADGERSPLLSEAGDGGAGGNGLAGPGGSATGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHAQQYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity).  Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).  Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity).  Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770).  May play a role in the regulation of cellular cholesterol metabolism (By similarity).
What are the official names of this protein?
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 1 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein.
Protein: ISOA3_ORYSJ
Sequence: MDSIGINRAPLGSSSSAAAVTARRGIALRPARRSVASTNRVGVATIGFGDASGLRACSEKVRRFDSVRSTTARAQNGNAGRSMTEERGCTMSDTEMPFKYSSGKAFPLGVSQVEGGLNFALFSQHASSVILCLKLPGRGTEDEKGADVVEFVLDQQKNKTGDIWHVIVEGLPASGVLYGYRVGGPQGWDQGHRFDSSTVLLDPYAKLVSGRKYFGVAEEKSSQHFGTYDFDSSPFDWGDDYRLPNLPEADLVIYEMNVRAFTADESSGLDSTSRGSYLGLIDKIPHLLELGVNAVELLPVFEYDELEFKRYPNPRDHMVNTWGYSTINFFAPMSRYASAGGGPVAASKELKQMVKELHKAGIEVILDVVYNHTNEADDAHPYMTSFRGIDNKVYYMLDLNKNAELLNFSGCGNTLNCNHPVVKELILDSLRHWVEEYHIDGFRFDLASVLCRGPDGCPLDAPPLIKEIAKDAVLSRCKIIAEPWDCGGLYLVGRFPNWDRWAEWNGKYRDDLRRFIKGDPGMKGVFATRVSGSADLYQVNERKPYHGVNFVIAHDGFTLCDLVSYNLKHNDANGEGGCDGCNDNFSWNCGVEGETNDLNVLSLRSRQMKNFHVALMISQGTPMMLMGDEYGHTRYGNNNSYGHDTCINNFQWEQLEQRRDGHFRFFSEMIKFRHSNPILRRDRFLNKNDVTWHEDCWENQESKFLAFTVHDHNSGGDIYLAFNAHDYFVDAVIPPPPHHKCWNRVVDTNLESPNDIVPEGVPFTGPKYRIAPYSSILLKAKP
What is the function of this protein?
Starch-debranching enzyme that plays a role in the degradation of transitory starch during the night in leaf blades, facilitates the formation of spherical amyloplasts containing compound granules in the endosperm, and affects morphological characteristics of plastids.
What are the official names of this protein?
Isoamylase 3, chloroplastic, OsISA3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Localizes in amyloplast stroma of seed endosperm.
Protein: PYRC_METMA
Sequence: MPDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVHVHFREPGMTLKENWYTGSCAAAAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDFGINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKEEDFEEALAEIKRLGALATIHAEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEAVGMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVNGLNDGTIDMVASDHAPHLESEKGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIMLTSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRADMLHSKAGWTPFEGIDAVFPEYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.