PharMolix/UniProtQA huggingface dataset:
Protein: HEMA_I80A1
Sequence: MEAKLLVLFCTFAALKADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLENSHNGKLCSLNGIAPLQLGKCNVAGWLLGNLECDLLLTANSWSYIIETSNSENGTCYPGEFIDYEELREQLSSVSSFEKFEIFPKASSWPNHETTKGVTAACSYLGASSFYRNLLWMTKKGTSYPKLSKSYTNNKGKEVLVLWGVHHPPTTSEQQTLYQNVDAYVSVGSSKYNRRFTPEIAARPKVRGQAGKMNYYWTLLDQGDTITFEATGNLIAPWYAFALNKGSDSGIITSDAPVHNCDTKCQTPYGALNSSLPFQNVHPITIGECPKYVKSTKLRMATGLRNVPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQSAIDGITNKVNSVIEKMNTQFTAVGKEFNNLERRIENLNKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVRNLYEKVKSQLRNNAKEIGNGCFEFYHKCDDECMESVKNGTYDYPKYSEESKLNREEIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAVSFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: DDPB_ECOLI
Sequence: MTFWSILRQRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGGGRLDDWLDPPTHVTGFYLLDALLEGNGEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRIGRGGGE
What is the function of this protein?
Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Probable D,D-dipeptide transport system permease protein DdpB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DIB1_YEAST
Sequence: MASVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHKRVS
What is the function of this protein?
Essential role in pre-mRNA splicing.  Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
What are the official names of this protein?
Spliceosomal protein DIB1.
What is the protein family that this protein belongs to?
Belongs to the DIM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMIF_HELAH
Sequence: MGSIGSIGKPIEGFLVAAIQFPVPIVNSKKDIENNVQSIIRTLHATKAGYPGVELIIFPEYSTQGLNTAKWLSEEFLLDVGGKETEAYAQACKEAKVYGVFSIMERNPDPNKNPYNTAIIINPKGEIILHYRKLFPWNPIEPWYPGDKGMPVCDGPGGSKLAVCICHDGMIPELAREAAYKGCNVYIRISGYSTQVNDQWILTNRSNAWHNLMYTVSVNLAGYDNVFYYFGEGQICNFDGTTLVQGHRNPWEIVTGEIYPKMADNARLSWGLENNIYNLGHRGYVAKPGGEPDAGLTYIKDLAASKYKLPWEDHMQIKDGSIYGYPTSGGRFGK
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: RL28_PELPD
Sequence: MSRICAICGKGPSFGNNVSHANNKTRTVWYPNLQKIKAVRNGSVKTIKVCTRCIRSGHVTKAL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: IF2G_HALLT
Sequence: MTEVNTQPEVNIGLVGHVDHGKTTLVQALSGSWTDQHSEEMKRGISIRLGYADATFRRCPGVDAPECYTVDEECEDGSESEPIRTVSFVDAPGHETLMATMLSGASIMDGAVLVVSATEDVPQAQTEEHLMALDLIGIENIVIAQNKVDLVDRDRAVDNYRQIQEFVEGTVAEDAPIVPVSAQQEVNMDLLIDAIESEIPTPDRDPGESARMYAARSFDINRPGATAAELKGGVVGGSLVSGELSVGDGLEIRPGREVDEEGQTEWRPLETTVRSLQAGSNDVESARPGGLLGVGTGLDPSLTKGDALAGQVAGEPGTLPPTRNEFEMQVDLLDRVIGSEEGDDGDVEDINTGEPLMLTVGTATTVGAVTSAREGECEVSLKRPVCAEKGAQIAINRRVGARWRLIGVGTLS
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: AROL_ECOK1
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDLWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSB_BORPE
Sequence: MRLLFLVLLVLLGLIQYPLWLGKGGWFKVWDLQRQVAEQRETNDGLRARNTALEAEVRDLATGVGAVEERARSELGMMREGEVFVHILPPGTPLPSDNSTPQASALSKPRPPATPPRR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: VP42_ISOHA
Sequence: EDDLSDFNPKV
What are the official names of this protein?
Venom peptide Sh42.
What is the protein family that this protein belongs to?
Belongs to the SA81-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: PNRC1_HUMAN
Sequence: MTVVSVPQREPLVLGGRLAPLGFSSRGYFGALPMVTTAPPPLPRIPDPRALPPTLFLPHFLGGDGPCLTPQPRAPAALPNRSLAVAGGTPRAAPKKRRKKKVRASPAGQLPSRFHQYQQHRPSLEGGRSPATGPSGAQEVPGPAAALAPSPAAAAGTEGASPDLAPLRPAAPGQTPLRKEVLKSKMGKSEKIALPHGQLVHGIHLYEQPKINRQKSKYNLPLTKITSAKRNENNFWQDSVSSDRIQKQEKKPFKNTENIKNSHLKKSAFLTEVSQKENYAGAKFSDPPSPSVLPKPPSHWMGSTVENSNQNRELMAVHLKTLLKVQT
What is the function of this protein?
Nuclear receptor coactivator.  May play a role in signal transduction.
What are the official names of this protein?
Proline-rich nuclear receptor coactivator 1, Proline-rich protein 2, Protein B4-2.
What is the protein family that this protein belongs to?
Belongs to the PNRC family. PNRC1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLK_BRUAB
Sequence: MQAIIDAEQSFKFPVLVGDIGGTNARFSILVDSNAEPKEFPVLQTADYATIDEAIQHAILDQTAIQPRSVILAVAGPVDGDEIDLTNCDWVVRPKKMIADLGFEDVTVLNDFEAQALAVVSLEGHHMEQIGGKPEEAVATRVVLGPGTGLGVAGLFRTRHAWVPVPGEGGHIDIGPRTERDYQIFPHIERIEGRVTGEQILSGRGLRNLYLGICAADKITPTLETPVDITSAGLDGSNPQAAETLDLFATYLGRLAGDLALIFMAHGGVYLSGGIPVRILSALKAGSFRATFEDKAPHKAIMRDIPVRVITYQLAALTGLSAFARTPSRFEVSTEGRRWRMRR
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_SHEB9
Sequence: MTAQIIDGKAIAQSIRTKLSEKVTARKEAGQRIPGLAVVLVGADPASQVYVGSKRKACEEVGFISRSYDLETSCSEDELLSLIDSLNEDPTIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRIADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLDNGTLVGDVQYDVAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ASP23_STAEQ
Sequence: MAVDNNKAKQAYDNQTGVNEQERKEQQQAQNNQPQFENKLTFSDEVVEKIAGIAAREVKGILDMKGGFTDSFTNAFSNGNNVTTGVSVEVGEKQAAVDLKVILEYGESAPKIFRKVTDLVKEQVKYITGLEVVEVNMQVDDVMTKKEWQQKNEKDNKENNEREGLK
What is the function of this protein?
May play a key role in alkaline pH tolerance.
What are the official names of this protein?
Alkaline shock protein 23.
What is the protein family that this protein belongs to?
Belongs to the asp23 family.
Protein: RPOC_CUPPJ
Sequence: MKALLDLFKQVQQEEQFDAIKIGLASPEKIRSWSYGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRLKHRGVICEKCGVEVTLAKVRRERMGHIELAAPTAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAFVVLEPGMTPLKKSQIMSEDDYLAKCDEYGEGEFVAMMGAEGIRELLRGIDIEKQIEQIRAELQATGSEAKIKKFAKRLKVLEAFQRSGIKPEWMILEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLAEMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKLMALELFKPFIFHKLETMGIATTIKAAKKEVESQTPVVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLFPANGDPSIVPSQDVVLGLYYTTRDKINGKGEGMTFADISEVIRAYENKEVELASRVNVRITEYELVDKDAEGDARFAPKITLQATTVGRAILSEILPKGLPFSVLNKPLKKKEISRLINTAFRKCGLRETVIFADKLLQSGFRLATRAGISIAIDDMLVPPAKEKIISEASAKVKEYDKQYMSGLVTDQERYNNVVDIWGAAGDQVGKAMMEQLQHEDVVDRNGNTVKQESFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSNGVAMKALVEGGEVIEALRDRILGRVTVADVVNPETQETAIETGTLLDEDLVDLIDALGVDEVKVRTPLSCDTRYGLCGKCYGRDLGRGVLVNSGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAVASSVEAKATGTVRFTVTMRYVTNAKGELIVISRSGEALITDDHGRERERHKIPYGATLLVQDGQAIKAGTQLATWDALTRPIVSEYTGTTKFENVEEGVTVAKQMDEVTGLSTLVVIDAKRRTAATKGIRPQVKLLDANGQEVKIPGTDHSVTIGFQVGALITVKDGQQVHVGEVLARIPTESQKTRDITGGLPRVAELFEARSPKDAAVLAEVTGTTSFGKDTKGKQRLVITDLDGNAHEFLIAKEKQVLVHDGQVVNKGEMIVEGPADPHDILRLKGIEELAHYIVDEVQDVYRLQGVKINDKHIEVIVRQMLRRVQVADVGDTKFIPGEQVERSELLDENDRVIAEGKRPATYENLLLGITKASLSTDSFISAASFQETTRVLTEAAIMGKTDDLRGLKENVIVGRLIPAGTGLAYHRARKAREASERERAQAIADEEQSLFIEPPPVVQATTEGEGDNA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: CORC_ECOLI
Sequence: MSDDNSHSSDTISNKKGFFSLLLSQLFHGEPKNRDELLALIRDSGQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLLPFMRSDAEAFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVKIPDDSPQPKLDE
What is the function of this protein?
Plays a role in the transport of magnesium and cobalt ions.
What are the official names of this protein?
Magnesium and cobalt efflux protein CorC.
What is the protein family that this protein belongs to?
Belongs to the UPF0053 family.
Protein: CSPL7_ARALL
Sequence: MKLIDRRMRLTELLLRCSISVFALLALILVVTDTEVKLIFTIKKTAKYTDMKAVVFLVVANGIAAVYSLLQSVRCVVGTMKGRVLFSKPLAWAFFSGDQAMAYLNVAAIAATAESGVIAREGEEDLQWMRVCNMYGKFCNQMAIGVSSALLASIAMVFVSCISAFSLFRLYGATRDRRTTPW
What are the official names of this protein?
CASP-like protein 2B1, AlCASPL2B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS1_STAAR
Sequence: MTEEFNESMINDIKEGDKVTGEVQQVEDKQVVVHINGGKFNGIIPISQLSTHHIDSPSEVVKEGDEVEAYVTKVEFDEENETGAYILSRRQLETEKSYSYLQEKLDNNEIIEAKVTEVVKGGLVVDVGQRGFVPASLISTDFIEDFSVFDGQTIRIKVEELDPENNRVILSRKAVEQEENDAKKDQLLQSLNEGDVIDGKVARLTQFGAFIDIGGVDGLVHVSELSHEHVQTPEEVVSIGQDVKVKIKSIDRDTERISLSIKDTLPTPFENIKGQFHENDDIEGVVVRLANFGAFVEIAPGVQGLVHISEIAHKHIGTPGEVLEPGQQVNVKILGIDEENERVSLSIKATLPNEDVVESDPSTTKAYLESEEEDNPTIGDMIGDKLKNLKL
What is the function of this protein?
Binds mRNA; thus facilitating recognition of the initiation point.  It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
What are the official names of this protein?
30S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
Protein: RNZ_STRP4
Sequence: MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAKKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: HRCA_SYNP6
Sequence: MLVSRLTARQQTILSATVRHYVRTAEPVGSKALAEQYGLSVSAATIRNAMGVLERAGLLYQPHTSAGRVPSEGGYRLYVDQLMEPDRALQRQTEQQLSQQLPDRRQSLEALLRGAAQILASLSGYLSLITFPLGLEFQVRHLQLVAIAPHQVLLIVVNDSYETQSALLTLPELDRDLEADQLDRQLLLLSNFLNQELQGRSLQALANLDWPVLGSELQSLAGILQQGLQDLEKRWQPTPATSLLVCGLADLLRQPEFNELQQVQALLELLEGEQTQLLPLMLADPAADQVRVRIGSELPLAPIRSCSLVSAFYCREQQPVGSVSLIGPTRMLYENAVAAVEATASYLSEAIAS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SYE_PORGI
Sequence: MINRRIRVRFAPSPTGPLHIGGVRTALYNYLFARQHGGDMILRIEDTDSNRFVPGAEAYIIEALEWLGIKFDEGVGYGGRFGPYRQSERRDIYRTYVRQLLDSGRAYIAFDTPEELEARRAEVPNFQYDATTRGQMRNSLTLPAEEVERLVAEGTQYVVRFLVEPNLDVEVNDLIRGRVVINSSILDDKVLYKSADDLPTYHLANIVDDHLMEVSHVIRGEEWLPSAPLHVLLYRAFGWEDTMPRFAHLALLLKPEGNGKLSKRDGDRLGFPVFPLEWKDPQTGDISKGYRESGYLPEAVVNFLALLGWNPGNDQDVMSMDELIRLFDIEKCSKAGAKFDYEKGRWFNHQYIQRKDNAELAELFRPILRENGVVATDEKTAHVISLVKERVNFIGELWEQAGFFFIAPLSYDEKTVKKRWKEDTAKQLGELAELLDSHRSFAAEATEPTVKNWIETNGYHLGNIMNATRLALVGESKGPHIFDIMEVLGREETVGRIRRAIEVLG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKTS1_CONST
Sequence: MEGRRFAAVLILTICMLAPGTGTLLPKDRPSLCDLPADSGSGTKAEKRIYYNSARKQCLRFDYTGQGGNENNFRRTYDCQRTCLYT
What is the function of this protein?
Blocks specifically voltage-activated potassium channels (Kv) of the Shaker family (IC(50)=1. 33 nM).
What are the official names of this protein?
Kunitz-type conkunitzin-S1, Conk-S1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB1_PHOPR
Sequence: MATGKIVQIIGAVVDVEFPQDSVPKVYDALKVDAKEKGTLVLEVQQQLGGGVVRCIAMGTSDGLRRGLSVENTDRPIEVPVGIATLGRIMNVLGEPIDECGEIGEEQRYAIHREAPSYEEQSNETSLLETGVKVIDLICPFAKGGKIGLFGGAGVGKTVNMMELINNIALQHSGLSVFAGVGERTREGNDFYFEMQEAGVVNLENPSESKVAMVYGQMNEPPGNRLRVALTGLTMAERFRDEGRDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKSGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGLYPAIDPLDSTSRMLDPLVVGQEHYDIARGVQSLLQRYKELKDIIAILGMDELSENDKQAVSRARKIERFLTQPYHVAEVFTGDPGIYVALKDTLRSFKGLLAGEYDDIPEQAFMYCGAIEDVLEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AK1CD_MOUSE
Sequence: MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRYLPAEFLVDHPEYPFVEEY
What is the function of this protein?
Catalyzes the dehydrogenation of 17-beta-hydroxysteroids.  May also exhibit significant activity with a variety of cyclic and alicyclic alcohols.  Uses both NAD and NADP, but the activity is much greater with NAD than with NADP (By similarity).
What are the official names of this protein?
Aldo-keto reductase family 1 member C13.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: QUEC_PSYWF
Sequence: MTDASADALTSPSNSGASQDTSQQNAVVLLSGGLDSVTCLYWAKARYAKVTAVSFNYGQRHNSELVAAKSIAGQAGVNHKIIDIDIAQLGGSSLTDHDMTVPDGDADKFPTHTDDIDNQAIPNTYVPARNTIFLSYALAVAEVTDANHIVIGVSSVDYSGYPDCRPEYIEAFEVMANLATKAGVTGHKLHIQTPLQKLSKAQTIQLGNSLGVDYSQTISCYKADSEGRACGICDSCTLRKRGFSDAGLADPTRYAG
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NUSB_SALPK
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: GRPE_CLOTE
Sequence: MKWRHDYMAEKKVEDLEMDLNEEELEESEVNEDKEFEELDKSEEENEVEELISTLKDENEKLNNEMEALKDRLLRTTGEYDNYRKRTDREKEGLYASACEDVLKEILPVLDNLERAILAKGDIEDLKKGVDMTLKQFKDSFKNLGVEEISTENGFDPNLHDAVMHVEDSQYGEKEVVEVFLKGYKKGDKIIRHSMVKVAN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF5_RABIT
Sequence: MRTLALLAAILLVTLQAQAELHSGMADDGVDQQQPRAQDLDVAVYIKQDETSPLEVLGAKAGVSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR
What is the function of this protein?
Microbicidal activity.
What are the official names of this protein?
Neutrophil antibiotic peptide NP-4, Microbicidal peptide NP-4.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATG4A_PONAB
Sequence: MESVLSKYENQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLGADTAGDRPPDSLTASNLSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTGENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3.  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.  Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity.  Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy.
What are the official names of this protein?
Cysteine protease ATG4A, Autophagy-related protein 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_CHLTE
Sequence: MIFPSVKEQLDIIVNNTVEVISTDELERKLTKSLKNGTPLKIKLGADPSRPDLHLGHSVVLRKLREFQDLGHEAILIIGDFTAMIGDPSGKSKTRPQLTAEEARENGKSYFEQASKILDPEKTTICYNADWLSQMHFADVIRLSSHYTVARMLERDDFEKRYRSQTPISIHEFLYPLAQGMDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIEPQVCITMPLLVGTDGSEKMSKSLGNAICFNDTPEDMYGRTLSIPDSLIETYWNLLVPHHSGNDKPIAERIAADPRETKRELARELVAQYYSAEEAAKAQEHFDRVIVNKQAPTDLPTVEFEEATMPVVELLMALAAFPSKNEARRMIQQGAVQAGNEKISDINAVIELTENPVIIRAGKRKFFKVARAKKSF
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.