PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_CORJK
Sequence: MAVSRQTSSVAGIPGAPQRHSFAKIDAPIEVPGLLDLQRESFAWLVGTPEWRARAQAEAGEDVRIMSGLEEILEELSPIEDYSENMSLTLSEPRFDDVKSTIDEAKDKDINYAAPLYVTAEFTNSMSGEIKSQTVFIGDFPMMTDKGTFIINGTERVVVSQLVRSPGVYFDASIDASTERPLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGLTTQEITDRFGFSELMMSTLEKDGVDNTDEALLEIYRKQRPGESPTRDSAQALLENSFFKAKRYDLAKVGRYKVNRKLGLGGDTDGVMTLTEEDILTTIEYLVRLHAGEKSMTSPDGTEIPIDTDDIDHFGNRRLRTVGELIQNQVRVGLSRMERVVRERMTTQDAESITPTSLINVRPVSAAIREFFGTSQLSQFLDQNNSLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSSYARVNPFGFIETPYRKVVDGQITDEVYYFTADEEDRHVIAQANTPFDENHRFTEERIEVRLRGGDVEVVPYTEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLLRSEAPFVGTGMELRAAYDAGDMIIAPKAGVVEYVSADYITVMDDEGVRDTFMLRKFERTNQGTCYNQTPLVDEGDRVEAGQVLADGPGTDNGEMALGKNLLVAFMPWEGHNYEDAIILNQRMVEEDVLTSIHIEEYEIDARDTKLGPEEITRDIPNVGEDVLADLDERGIVRIGADVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSMKVPHGETGKVIGVRVFSREDDDDLAAGVNEMVRVYVAQKRKIQDGDKLAGRHGNKGVVGKILPQEDMPFLPDGTPIDIILNTHGVPRRMNIGQVLEVHLGWLAKAGWKVDPDSQDPKIQKMLETLPEELYEIPADSLTATPVFDGASNAELSGLLRSSLPNRDGERQVDDFGKSNLIDGRSGEPFPYPVAVGYMYMLKLHHLVDEKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGENIPDPGIPESFKVLLKELQSLCLNVEVLAADGTPMELSSDDDDELENANAALGINLSRDERPDADMDVS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CMT1_ORYSJ
Sequence: MVPEPAPAAATEPRRSTRRRLMTAAAMEAEAEAVADLDEIDREMSRAESRKRQRRTAKEKPGARKGATEWKPEDVEKAAAAEGVAELDEIDREMPRPELRKRQRRTAKEKPSAHEGATEWKPEDVEKAAAQEPEGTELDSGLSPAESRGKRQRGVEKVKRRTRKKTAKEKTKETTEKSAAQAPEKMKVNDAGGALAEDVCADEPDAEQMAMEEEEEAADVLEAEERMGKCVGEGSAEKAATRKRVARPSTARRVEDSDDHFVGDPVPDDEARQRWPVRYSRKGSDSLLKQEPDEDEEMKARCHYLAANVDDEIYHLDDDVYVKAGPDEENYIGRITEFFEGVDRGSYFSCQWFFRTADTVISSKLLKVHDHRHNHKRVFLSKEKNDNLIECIVSKVKIAHVDPNMTPQARAHAISDCDLYYDMSYSVAYSTFANLPADNDGALGSEATSNISCDDADNSSKGKLSADIVAPYSEQTETASLLDLYSGCGAMSTGLCLGFAFSGINLETRWAVDINKYACACLKHNHPYSQVRNEKTEDFLALIQQWDALCRKYVVHKNDTLEPSIDMPLNDADDVNEPLPEDIFDVEELLEICYGDPSNTGKNGLWFKVRWKGYDPSYDTWEPIDGLSDCPERIKEFVEKGHKENILPLPGAVDVICGGPPCQGISGFNRFRKHNDPLEDEKNKQLVVFMDIVKYLRPKYVLMENVVDILKFADGFLGRYAMSCLVAMNYQARLGMMAAGYYGLPQFRMRAFLWGALPSMVLPKFPLPTHDAVVRGIVPTTFSQSVVAYNEVDTRCLRKALLLADAISDLPKVGNDQPKDVIEYSVAPKTEFQRYIRNNRKDIQDYSFRGDDPSEEGKLFDHQPLKLNKDDYERVQRIPVKKGANFRDLKGVIVGPDNTVRLDPNISRERLSSGKPLVPDYAISFVKGKSTKPFGRLWWDETVPTVVTRAEPHNQIILHPSQDRVLTIRENARLQGFPDYYRLIGPLKEKYIQVGNAVAIPVARALGYALGLAYRGESDGDRAVLKLPESFIYADQETVVKSSAGTPGSEIADSEQLFE
What is the function of this protein?
Involved in CpXpG DNA methylation (By similarity).  May not play a major role in maintaining CpXpG methylation (Probable).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase CMT1, Chromomethylase 1, OsMET3b.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CY11_SOLTU
Sequence: MSLGKKIRIGFDGFGRINRFITRGAAQRNDSKLPSRNDALKHGLDGLGSAGSKSFRALAAIGAGVSGLLSFATIAYSDEAEHGLECPNYPWPHEGILSSYDHASIRRGHQVYQQVCASCHSMSLISYRDLVGVAYTEEETKAMAAEIEVVDGPNDEGEMFTRPGKLSDRFPQPYANEAAARFANGGAYPPDLSLITKARHNGQNYVFALLTAYRDPPAGVSIREGLHYNPYFPGGAIAMPKMLNDGAVEYEDGIPATEAQMGKDVVSFLSWAAEPEMEERKLMGFKWIFVLSLALLQAAYYRRLRWSVLKSRKLVLDVVN
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.  Cytochrome c1 is a catalytic core subunit containing a c-type heme.  It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
What are the official names of this protein?
Cytochrome c1-1, heme protein, mitochondrial, Complex III subunit 4-1, Complex III subunit IV-1, Cytochrome b-c1 complex subunit 4-1, Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit 1, Cytochrome c-1-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PYRC_SALHS
Sequence: MTAPSQVLKIRRPDDWHVHLRDGDMLKTVVPYTSEIYGRAIVMPNLASPITTVDAAIAYRQRILNAVPAGHDFTPLMTCYLTDSLDADELERGFHEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKLGMPLLVHGEVTHADVDIFDREARFIDTVMEPLRQRLTTLKVVFEHITTKDAAQYVRDGNDYLAATITPQHLMFNRNDMLVGGIRPHLYCLPILKRNIHQQALRELVASGFTRAFLGTDSAPHSRHRKETSCGCAGCFNAPSALGSYAAVFEEMNALAHFEAFCSLNGPQFYGLPVNAGWVELVRDEQQIPGNIALADDSLVPFLAGETIRWSVKK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: ACHB2_CARAU
Sequence: LRSDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNEREQIMTTNVWLTQEWTDYRLVWDPNEYEGIKKLRIPSQHIWLPDIVLYNNADGVYEVSFYCNAVVSNTGDIFWLPPAIYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLVLTSDFASRDDYTPSGEWDIVSLPGRKNEDPNDLTYLDITYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKVTLCMSVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHYMPEWVKCVFLHKLPAFLLMRRPGRSNVRERFRRKHQRKSFSSHQDGDSFFLTDDPGRVCGAWRVGDLPEGSEFRQRVKVRHDQDVDEAIDGVRFIAEHMKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFVQPLFQSYNTPVAEEVYGDF
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit beta-2, GF-beta-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: ZNF79_HUMAN
Sequence: MLEEGVLPSPGPALPQEENTGEEGMAAGLLTAGPRGSTFFSSVTVAFAQERWRCLVSTPRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWMLEGEDLRSPSPGWKIISGSPPEQALSEASFQDPCVEMPPGDSDHGTSDLEKSFNLRPVLSPQQRVPVEARPRKCETHTESFKNSEILKPHRAKPYACNECGKAFSYCSSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYRCSECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCSECGKAFSYCAAFIQHQRIHTGEKPYRCAACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNECGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECSECGKAFRCSSAFVRHQRLHAGE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 79, ZNFpT7.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DHOM_MYCLE
Sequence: MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVSARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGARIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL
What are the official names of this protein?
Homoserine dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the homoserine dehydrogenase family.
Protein: 3HAO_BURL3
Sequence: MLKYGTPFNFSRWIDEHAHLLKPPVGNQQVWQDSDFIVTVVGGPNHRTDYHDDPFEEFFYQLRGNAYLHLWIDGKRERVDLKEGDMFLLPPHVRHSPQRPEAGSACLVIERQRPAGVVDGFEWYCDACGHLVHRVEVQLKSIVDDLPPLFDAFYASDTLRRCAHCGHMHPGKAT
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
Protein: MDTB_SALCH
Sequence: MQVLPPGSTGGPSRLFILRPVATTLLMAAILLAGIIGYRFLPVAALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPIYSKVNPADPPIMTLAVTSNAMPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAVAALGLTSETVRTAITGANVNSAKGSLDGPERAVTLSANDQMQSADEYRRLIIAYQNGAPVRLGDVATVEQGAENSWLGAWANQAPAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSQQSLRKQNRFSRACERMFDRVIASYGRGLAKVLNHPWLTLSVAFATLLLSVMLWIVIPKGFFPVQDNGIIQGTLQAPQSSSYASMAQRQRQVAERILQDPAVQSLTTFVGVDGANSTLNSTRLQINLKPLDARDDRVQQVISRLQTAVATIPGVALYLQPTQDLTIDTQVSRTQYQFSLQATTLDALSHWVPKLQNALQSLPQLSEVSSDWQDRGLAAWVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTASTPGLAALETIRLTSRDGGTVPLSAIARIEQRFAPLSINHLDQFPITTFSFNVPEGYSLDDAVQAILDTEKTLALPADITTQFQGSTLAFQAALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALIIAGSELDIIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIAMVGGLLVSQVLTLFTTPVIYLLFDRLSLYVKSRFPRHKEEA
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBB2_IGUIG
Sequence: VHWTAEEKQLITCLWGKVDVPTVGADALAGMLVMYPWTQRFFADFGNLSSATAICGNPKVRAHGKKVLTAFGDAIKNLDNIKDTFAKLSELHCDKLHVDPENFKLLGNVLIIVLAGHYGKDFTPACHAAYQKLVNVVAHALARRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-2, Beta-2-globin, Hemoglobin beta-2 chain, Hemoglobin beta-II chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PRU1_PRUAV
Sequence: MGVFTYESEFTSEIPPPRLFKAFVLDADNLVPKIAPQAIKHSEILEGDGGPGTIKKITFGEGSQYGYVKHKIDSIDKENYSYSYTLIEGDALGDTLEKISYETKLVASPSGGSIIKSTSHYHTKGNVEIKEEHVKAGKEKASNLFKLIETYLKGHPDAYN
What are the official names of this protein?
Major allergen Pru av 1, Allergen Pru a 1.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: GPMI_PSEAB
Sequence: MTATPKPLVLIILDGFGHSESPDYNAIYAAKKPVWDRLLATQPHGLISGSGMDVGLPDGQMGNSEVGHMNLGAGRVVYQDFTRVTKAIRDGEFFENPVIAAAVDKAVAADKAVHILGLLSPGGVHSHEDHLVAMAQMAARRGAGKIYLHAFLDGRDTPPKSAQPSLERLDATFAGLGKGRIASIIGRYFAMDRDNRWDRVQAAYELIVDGKAEFTADSSVAALEAAYARGESDEFVKATAVVPAGAEAVRVEDGDAVIFMNFRADRARELSRAFVEPAFKEFPREQAPQLAGFVMLTQYAASIPAPCAFPPEPLTNVLGEYLAKHGKTQLRIAETEKYAHVTFFFSGGREEPYEGEERILIPSPKVATYDLQPEMSAPEVTDRIVEAIEQQRYDVIVVNYANGDMVGHTGVFEAAVKAVECLDTCMGRIVEALDKVGGEALITADHGNVEQMEDESTGQAHTAHTCEPVPFVYVGKRKLSIREGGVLADVAPTMLTLMGLEQPAEMTGRSIVTLG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: HIS8_ECO7I
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIDNYAQYAGIKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLTEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVVQIIAEREYLIAALKEIPCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: V185_AMEPV
Sequence: MSSSKKNNLGYFNNLKTEEVSQSQVFKDNYRPGYYGLDTNAANPADVYNTESNKPSTVDVWGDKRLEGKIIPKSKKKK
What are the official names of this protein?
Uncharacterized protein AMV185/G3L.
Protein: U2QL1_MOUSE
Sequence: MKELQDIARLSDRFISVELVNENLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG
What is the function of this protein?
Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins.  May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2Q-like protein 1, E2Q-like ubiquitin-conjugating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MRP1_RAT
Sequence: MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRHDRGYIQMTHLNKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVFIQLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV
What is the function of this protein?
Mediates export of organic anions and drugs from the cytoplasm.  Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics.  Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export.  Hydrolyzes ATP with low efficiency (PubMed:15129170).  Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692).  Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
What are the official names of this protein?
Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INSI1_RAT
Sequence: MPRLHDHVWSYPSAGAARPYSLPRGMIAAALCPQGPGAPEPEPAPRGQREGTAGFSARPGSWHHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR.  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2.  Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum.  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi.  Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2.  Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139.  Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78.
What are the official names of this protein?
Insulin-induced gene 1 protein, INSIG-1, Immediate-early protein CL-6, Insulin-induced growth response protein CL-6.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ENGB_SYNAS
Sequence: MKIVTVEFVKSATLPSGYPPGSLPEVAFVGRSNVGKSSLINTLLRRKQLARTSNTPGRTQLINFFNVNQELLFVDLPGYGFARVPEAVKREWGPMIETYLRDRECLRMVVFILDIRRDPSQEDLALKGWLDYYGRRTLFVLTKSDKLSRGESKRRQRSVQESLALPEMPLIFSAKTGLGRERILEEIRKAKGEARS
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ACCA_PROMP
Sequence: MPRRYLLDFEKPLVELEKQIEQIRELARDSEVDVSQQLLQLETLATRRREEIFRSLTPAQKIQVARHPQRPSTLDFIQMFCDDWIELHGDRNGGDDMALIGGLGSVNNQPVLLLGHQKGRDTKENVVRNFGMAKPGGYRKALRLMQHADRFSLPILTFIDTPGAYAGLSAEEQGQGEAIARNLREMFGFKVPIIATIIGEGGSGGALGIGVADRLLMFEHSVYTVASPEACASILWRDAAKASEAATALKITGKDLLELGVIDEVLSEPAGGNNWAPIEAGNTLKGAIEKHLNELLELKKEELLEQRYSKFRVLGKFVESNNFEEIQEQLPQITE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHA7_BOVIN
Sequence: MRGSLCLALAASILHVSLQGEFQRKLYKDLVKNYNPLERPVANDSLPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMTWTDHYLQWNASEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGVLGKRSEKFYECCKEPYPDVTFTVSIRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPACQHNERRCSLASVEMSAVAGPPATNGNLLYIGFRGLDTMHCAPTPDSGVVCGRVACSPTHDEHLLHAGQPSEGDPDLAKILEEVRYIAHRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTILCTIGILMSAPNFVEAVSKDFA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  The channel is blocked by alpha-bungarotoxin.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-7.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=TMEM35A/NACHO and RIC3 promote its trafficking to the cell membrane.
Protein: TIPK_LAMBD
Sequence: MSPEDWLQAEMQGEIVALVHSHPGGLPWLSEADRRLQVQSDLPWWLVCRGTIHKFRCVPHLTGRRFEHGVTDCYTLFRDAYHLAGIEMPDFHREDDWWRNGQNLYLDNLEATGLYQVPLSAAQPGDVLLCCFGSSVPNHAAIYCGDGELLHHIPEQLSKRERYTDKWQRRTHSLWRHRAWRASAFTGIYNDLVAASTFV
What is the function of this protein?
Plays a role in tail tip complex assembly.  The tail tip complex is assembled successively with three tail tip proteins J, one tail tip protein I, one tail tip protein L and one tail tip protein K.  The tail tip complex interacts with tail measure protein to initiate tail tube assembly.  The formation of the tail tip complex is completed by the addition of tail tip protein M, which is followed by tail tube polymerization.  May be excluded form tail tip during maturation and would be absent from virions.  May be involved in tail measure protein processing.
What are the official names of this protein?
Tail tip assembly protein K, Probable endopeptidase, Tail assembly protein K.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: HIS2_PYRIL
Sequence: MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRIVEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.