PharMolix/UniProtQA huggingface dataset:
Protein: SH3R3_MOUSE
Sequence: MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFLSAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFVESF
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase SH3RF3, Plenty of SH3s 2, SH3 domain-containing RING finger protein 3, SH3 multiple domains protein 4.
What is the protein family that this protein belongs to?
Belongs to the SH3RF family.
Protein: PILR2_THUPL
Sequence: MEESSRVLIVGGTGYIGRRIVKASIALGHPTFILFRKEVVSDVEKVEMLLSFKKNGAKLLEASFDDHESLVDAVKQVDVVISAVAGNHMRHHILQQLKLVEAIKEAGNIKRFVPSEFGMDPGLMEHAMAPGNIVFIDKIKVREAIEAASIPHTYISANIFAGYLVGGLAQLGRVMPPSEKVILYGDGNVKAVWVDEDDVGIYTIKAIDDPHTLNKTMYIRPPLNILSQKEVVEKWEKLSGKSLNKINISVEDFLAGMEGQSYGEQIGISHFYQMFYRGDLYNFEIGPNGVEASQLYPEVKYTTVDSYMERYL
What is the function of this protein?
Reductase involved in lignan biosynthesis.  Catalyzes the enantioselective sequential conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol.  Can also convert with a lower efficiency (-)-pinoresinol into (-)-lariciresinol, but not (-)-lariciresinol into (+)-secoisolariciresinol.  Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase 2, PLR-Tp2, (+)-lariciresinol reductase, (+)-pinoresinol reductase, (-)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: RAD18_KLULA
Sequence: MKLSVPETISNPRDFLHTSVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESMLQKEFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEADTSVGTKRGTPDSPSLSSVSTKKRKHDGITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELEGSHIDECLNKGSSLERSDSFEILDERTPSPSMESSHQPLEEKTSLPSSHLLEVKEKKDITYHNERYLNSGLLQQKENRLPRLDFQSLSMTQLKQKLASLALPSNGTKQQMVARYKHYEMLWNSNFLDSIDPVDENELKRRLSSWEAKHNTDHSSDSNSITNLLRGNKRTNAISAMIKLFKSDRFDRKGWMRHHTSTFKALKLEAQRSDKLAKMKKEELSQKSDANSEVSSEPILKIDQTSENN
What is the function of this protein?
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group.  Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
What are the official names of this protein?
Postreplication repair E3 ubiquitin-protein ligase RAD18, RING-type E3 ubiquitin transferase RAD18.
What is the protein family that this protein belongs to?
Belongs to the RAD18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIC60_CANTT
Sequence: MIRIAARNANRSTAIRSISTTSIRLNTTQKVVVTPPPVATEGELPPPQPKVTPPKATPPPPPKTKRFSLFGFLLKTTLLASVVYGGTLYAATKNDKVMDFVVDNRLPYHEELLELIETGSIDDLQQGLDQLKSKFGSVKLPSKEEIDELAQKLEHKGEDIIKETKKKFTATRTGTDLTPSEQLQKGVEIESVKKDVPHLPLIELNSELGSSVDETVKQTIASFNNFIQTIDASTLASKNDKLIASINFSISQLASKLNGLTKSFDEELQKKLKVSQTELFSSFTKKELELTENLLHQFTTEKQQLEAKLNEKLNQEIQASRTAISQAATNAVSMVRIEQTKNFEKLVTEKLNEERNGRLANLDKLNDRLTELEKFAEGFETQIVSNHKKALIQQAVSKLKSLLLAPAANEKPKSIKPYVDELSKIAADDEVLKLALKDLTPLLSNESTHSILTNAQLLSRWEQLAPELRSASLLPPNAGLLGHLASIVFSKLLLPVKGVKQDGKDIESVIGRVESSLARGELDVAVEEAANLKGWSRKLANDWVVEGRKRLEVEFLLGLIESESKII
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RL32_BORBR
Sequence: MAVQQNKKSPSKRGMHRSHDFLVNPATAIEPNTGETHLRHHISPNGFYRGRKVLKTKADE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: FABP1_CAEEL
Sequence: MCAKIALLLVLVGAASAAVLPDKFYGTFDLDHSENFDEYLTAKGYGWFTRKLVTFATFKKVFTKTSNKNLFDYSNLTSKKDVHYKNVQLGKAFQGEGLDSTKHEITFTLKDGHLFEHHKPLEGGDAKEETYEYLFDKEFLLVRMSFNGVEGRRFYKRLP
What is the function of this protein?
May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell.
What are the official names of this protein?
Fatty acid-binding protein homolog 1, Lipid-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Secreted. Note=From the hypodermis into the perivitelline fluid of the developing embryo prior to hatching.
Protein: DTXH_CORBE
Sequence: MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGDVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVKLEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGGSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNRVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRSAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIASVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
What are the official names of this protein?
Diphtheria toxin homolog CRM228.
Protein: YIDD_PSE14
Sequence: MRKLALVPIQFYRYAMSPLMASHCRFYPSCSCYAYEAIENHGLLRGGWLSIRRLGRCHPWNPGGYDPVPAVPTSRSSSMAE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COX23_EMENI
Sequence: MASHPEQQSSSSSADVSSSSWGKVERKFTNKSASEYYDPCQDFADRSLRCMKRNPDDRDMCHDYFQAYRDCKKQWLTQKKLGSSSTAK
What is the function of this protein?
Required for the assembly of cytochrome c oxidase.
What are the official names of this protein?
Cytochrome c oxidase-assembly factor cox23, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX23 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: CDC61_AERPE
Sequence: MEEVFTAALESKIFRKRWVLLPDYVPDVLPHREAELRRLAEVLAPALRGEKPSNALLYGLTGTGKTAVARLVLRRLEARASSLGVLVKPIYVNARHRETPYRVASAIAEAVGVRVPFTGLSVGEVYERLVKRLSRLRGIYIIVLDEIDFLPKRPGGQDLLYRITRINQELGDRVWVSLVGITNSLGFVENLEPRVKSSLGEVELVFPPYTAPQLRDILETRAEEAFNPGVLDPDVVPLCAALAAREHGDARRALDLLRVAGEIAERRREERVRREHVYSARAEIERDRVSEVVRTLPLHAKLVLLSIMMLEDGGRPASTGEIYERYKELTSTLGLEHVTLRRVSGIISELDMLGIVKSRVVSRGRYGKTREVSLDADRLAVENALSEDPFVARLL
What is the function of this protein?
Involved in regulation of DNA replication (By similarity).  Binds DNA.
What are the official names of this protein?
ORC1-type DNA replication protein 1, ORC1.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: LEUC_BRUSU
Sequence: MSAPRTLYDKIWDDHVVDQQEDGTCLLYIDRHLVHEVTSPQAFEGLRMAGRPVRHPEKTLAVVDHNVPTSPDRINGIQNEESRIQVEALARNAADFGVEYYSERDKRQGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAKNMLVRVDGKLPAGVTAKDIVLAIIGEIGTAGGTGYVIEYAGEAIRSLSMEGRMTICNMSIEGGARAGLIAPDETTFEYIKGRPRAPQGETLEQAINYWKTLHSDEGAHFDKIVTLDAGSLPPIVSWGSSPEDVVSVTGVVPNPDDIADETKRASKWRALDYMGLKPGTKITDIAVDRVFIGSCTNGRIEDLRAAAKVVEGKKVAPTVNAMIVPGSGLVKEQAEAEGLHKIFIEAGFDWREPGCSMCLAMNDDRLKPGERCASTSNRNFEGRQGFKGRTHLVSPAMAAAAAIAGHFVDIRAWK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RL21_CUPNH
Sequence: MYAVVKTGGKQYKVAAGEKLKVEQIPADIGAEITLDQVLAVGAGDQIKFGTPLVSGASVKATVISQGRHDKVKIFKMRRRKHYQKRQGHRQNYTELRIEAIVA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HTPX_ECO57
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLMIMALLFGFGGSFVSLLMSKWMALRSVGGEVIEQPRNERERWLVNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRILAQLAAGFMGGNRDEGEESNGNPLIYFAVATVLELVFGILASIITMWFSRHREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRTGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DCD_DRYCA
Sequence: MLPYNQDFYNEDEALKDDHCEGAGNVSNPPTLDEAIKRSQDFLLSQQYPEGYWWAELEGNPTITSHTVILYKILGIEDEYPMDKMEKYLRRMQCIHGGWELFYGDGGQLSVTIESYVALRLLNVPPTDPALKKALKFIIDKGGVXKSRMFTKICLALLGCFDWRGIPSLPPWVMLLPGWFLSSIYETACWARGCVVPLIVVFDKKPVFKVSPEVSFDELYAEGREHACKTLPFCGDWTSHFFIAVDRVFKMMERLGVVPFQQWGIREAEKWLLERQEDTGDFLGVYPPMFYSVVCMKTLGYEVTDPVVRRALLSFKKFSIERADECSVQSSLSPVWDTALVVRSLVESGLPPDHPALQRAGEWLLQKQITKHGDWSFKNQSGVAGGWAFQFFNRWYPDLDDSAVVVMALDCLKLPNEDVKNGAITRCLKWISSMQCKGGGWAAFDKDNHQHWINSTPFSDLKAMVDPSTTDISARVLEMVGRLKLHGTSFDEAHFLPPESIARGLVYLRREQENEGCWFGRWGVNYIYGTCGALVALSLVAPMTHEEEIARGARWLVQVQNMHGKKINGPQDGGWGETCFSYNDPALKGQGDVSTASQTAWALQGLLAAGDALGKYEVESIGHGVQYLLSTQRKDGSWHESQFTGGGFPIHFYLRYHFYAQHFTLSSLARYRTRLQASKIKPPIP
What is the function of this protein?
Squalene cyclase producing the tetracyclic triterpene dammaradiene.
What are the official names of this protein?
Dammaradiene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: XRCC4_HUMAN
Sequence: MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
What is the function of this protein?
Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486).  This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486).
What are the official names of this protein?
DNA repair protein XRCC4, hXRCC4, X-ray repair cross-complementing protein 4.
What is the protein family that this protein belongs to?
Belongs to the XRCC4-XLF family. XRCC4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to site of double-strand breaks. SUBCELLULAR LOCATION: [Protein XRCC4, C-terminus]: Cytoplasm. Note=Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3).
Protein: IDI_ECOUT
Sequence: MQTEHVILLNAQGVPTGTLEKYAAHTADTLLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEEAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLAAVLRGIDATPWAFSPWMVMQATNREARKRLSAFTQLK
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_VIBCH
Sequence: MPMSLGNAFIKNFLGKAPDWYKVAIIAFLIINPIVFFFINPFLAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGMTSPGQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILLGIRSKVLLSIAFSVTAAFLSAFLDALTVIAVIISVAVGFYSIYHKVASGQSVHSSHDHTHDEGISELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQAGWQFGEFLLRMAPVTVPVFIAGMLTCMLVEKFRIFGYGARLPANVRQILLDFDSEERKNRTNQDVAKLWVQGAIAVWLIVGLALHLAAVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLNVEDHGTQLALFYVANGLLSMVSDNVFVGTVYITEVKTALMEGMISRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVIMAFPYTLALSLVGFIGIMFLLEPMTEVFYSLGWISHHVAPAADALLQSGH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS14_MANSM
Sequence: MAKQSMKARDVKRVKLAEKFYAQRVELKRIISDVNSSDEERWDAVLKLQTLPRDSSPSRQRNRCSQTGRPHGVLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: DNAK_LEPBL
Sequence: MSKEKIIGIDLGTTNSVVSVMEGGDPVVIQNSEGARTTPSIVAFTAKGENLVGQFAKNQAITNAVNTIRSAKRFIGRRIGECESEMKHVSYKVIRSGNEGVKFETSAGEFTPQEISARVLMKMKQTAEDYLGQKVTKAVITVPAYFNDEQRQATKDAGRIAGLEVERIINEPTAAALAYGFDKKNVNSKIAVYDLGGGTFDISILELADGVFEVKSTNGDTHLGGDDFDMAIMEWMISEFKNQTGIDISADKNTVQRLKEAAEKAKIELSGTMSTQINLPFITADASGPKHLDMTLSRAKFDQLTKSLVDRTRIPCENALRDAGLKASDINEVILVGGSIRIPAVQELVKQIFGKEPNKSVNPDEVVAVGAAIQGGVLAGEVSDVLLLDVTPLSLGIETLGGVMTKLIERNTTIPTKKSQVFSTAADNQSAVSIHVLQGEREMASANRTLGRFDLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDLGTGKEQKIRIESSSGLSEDEIQKMVKDAEAHAAADKAQREVIEAKNELDTLAYSLEKTVNEAGDKIGASEKQLATDEVKRAREAIESNDKARMESAKASISKIASDIATKVYSQGAPGAEQAAGSTGPDQGQNDQGNSGNNGEKVVDADYTVVDDEKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: YMGE_ECO27
Sequence: MGIIAWIIFGLIAGIIAKLIMPGRDGGGFFLTCILGIVGAVVGGWLATMFGIGGSISGFNLHSFLVAVVGAILVLGVFRLLQRE
What are the official names of this protein?
UPF0410 protein YmgE, Transglycosylase-associated gene protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0410 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENS2_YEASX
Sequence: MKKQNLNSILLMYINYIINYFNNIHKNQLKKDWIMEYEYMYKFLMNNMTCFIKWDNNKILLLLDMYYNVLYNYHKQRTPMSNKRLMNSKNIMDYKLLYTYFYILNKMKMEMDNYNNNNNNISLKYNELLKNIMNNLNYKTSNIETNLSNNFYLMDKYLINKYMKYLDMLNMIPNNYMFNNINYKGKLNIKTVLDLNNNEFYDYLSGLIEGDGYIGPGGITITNHANDVLNTIFINKRIKNSILVEKWMDTLKDNPYFVNAFSINIKTNLAKEKIFTNIYNKLYSDYKINQINNHIPYYNYLKINNKLPIKNIMDIKNNYWLAGFTAADGSFLSSMYNPKDTLLFKNMRPSYVISQVETRKELIYLIQESFDLSISNVKKVGNRKLKDFKLFTRTTDELMKFIYYFDKFLPLHDNKQFNYIKFRFNTFIKSYNWNNRVFGLVLSEYINNIKIDNYDYYYYNKYINMHNARKPKGYIK
What is the function of this protein?
Catalytic component of endonuclease SceI (Endo. SceI), which cleaves specifically at multiple sites on mitochondrial DNA and produces double-stranded breaks.
What are the official names of this protein?
Endonuclease SceI small subunit, Endo.SceI 50 kDa subunit, Maturase-like RF3 protein.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VPC23_MYCTO
Sequence: MIFVDTNVFMYAVGRDHPLRMPAREFLEHSLEHQDRLVTSAEAMQELLNAYVPVGRNSTLDSALTLVRALTEIWPVEAADVAHARTLHHRHPGLGARDLLHLACCQRRGVTRIKTFDHTLASAFRS
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  The cognate antitoxin is VapB23 (By similarity).
What are the official names of this protein?
Ribonuclease VapC23, RNase VapC23, Toxin VapC23.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: FADA_PSEMY
Sequence: MSLNPRDAVIVDFGRTPMGRSKGGMHRNTRAETMSAHLISKVLERNAKIDPAEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAGQTVSRLCGSSMSALHTAVQAIQTGNGDVFVVGGVEHMGHVGMMHGVDPNPHLSLYAAKASGMMGLTAEMLGKMHGISREAQDAFGERSHRLAHKATVEGKFKDEIIPMQGYDENGFLKVFDYDETIRPETTLESLATLKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPMAVVRAMAVAGVDPAIMGYGPVPSTQKALKRAGLTMADIDFVELNEAFAAQALPVLKDLKLLDKMEEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVSTMCVGLGQGITTVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_CAMJJ
Sequence: MQENLLEKQFLNHPLYTKIQELKALNLTCNFSLDDSVNLSTNSQAKDEILAITKELKPWRKGPFKIDDLFIDTEWQSFIKFNILKPFMNEISQKCVADIGCNNGYYMFKMLEFNPAKLIGFDPSIKYRLQFELINALAKTPIKYELLGVEDLPSYSLKFDVIFCLGVIYHRSDPVKMLKDLKAGLNKNGVVFLDTMYIEDEREIALVPNKTYSKIPNIYFVPSISALKNWCERAGFKEFEVLATKKTDENEQRKTEWIDSFSLENFLDPKDKNLTIEGYEAPKRVYIRIKI
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: ERA_CLOBH
Sequence: MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASEAMKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLLKELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPIIIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RPOA_METFK
Sequence: MQNSPTEYLKPRVVDVDVISPVRARVTLEPMERGFGYTLGNALRRVLLSSIPGFAITEVKIDGVVHEYSTLDGVQEDVVDILLNLKGVALKLNSKNEATLTLNKSTEGVVTAGDFDTGHDAEIANPDHVIAHLTKGGKLNLEVKVEMGRGYQPVPQRRKTEDEDRVLGFIQVDASFSPISKVSYQVESARVEQRTDLDKLIMDVETNGIIEPEQAIRDAARILMGQLSVFADLEGAPSEVEVKQAPQVDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKAPNLGRKSLNEIKDVLASKGLTLGMKLENWPPAGLEKV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SGPL1_RAT
Sequence: MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQGGIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR
What is the function of this protein?
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine.  Elevates stress-induced ceramide production and apoptosis (By similarity).  Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts.  Involved in the regulation of pro-inflammatory response and neutrophil trafficking.  Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity).  Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).
What are the official names of this protein?
Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL, SPL 1, Sphingosine-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
Protein: TRMA_MANSM
Sequence: MQQLPIEKYSELLTKKQQKLTALLAPFNAPELSVFVSPVQNYRMRAEFRVWHDKGDLYHIMFNQQTKQRYRVDCFPIASLLINRMMENLIPLLKEQEILTKKLFQIDYLSTLSNKIIVSLLYHKTLTEEWQAAAQALKVRLEKLDFDVQIVGRATKQKICLERDYADEVLPVNGRNYVYRQIENSFTQPNAAVNCKMLEWAIGCTKNSSGDLLELYCGNGNFSIALAQNFRKVLATEIAKPSVAAAQFNIAENGIDNLQIIRMSAEEFTQAMNGVREFNRLKGIDLKSYECNTIFVDPPRAGLDPDTVKLVQNYDRILYISCNPNTLCNNLTELTKTHRIEKAALFDQFPYTDHMESGVWLIRK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.