Protein: AUSA_PENBI
Sequence: MGSLGDLPLNRISVLFGSKYSEIDRSALHIRRYLSTHRAATWLEDAVEDLPSVWQDVTKVWPAGEGIHGEAGLQQLSAFLRGEELPLNMEDPMNYLLMPITVLRHLVDFHEFKEAGSDCDIKSMQGFCAGYLAAVAGCWEKDQSEFSKVVATMVRTAIFIGAAVDLDELATQRATSIAVRWKTAEAYKPFAATLGRYPGAYIACITDESSVTVTVWEDQAAALVQELEGNGLLVKDTRLRGRFHHADHLSAAQDILKLCQQDTRFQLPNTCPARELPRSNADGDLPTLKSVLSVVIQSILISQADWNLTVSNTLNSLDSSDAKCILSIGAGQFLPRQARSQILNAIDSSRGDNLVNGDHDNIAITNGTSFAASSVNGTAPVPTSIPIAVTGLACRYPQADCVEELWKILEQGLCTVSRMPESRLKPDRLQRKPDGPFWGNFISRPDAFDHRFFKISAREAESMDPQQRLLLQVAYEAMESAGYCGLRATNLPEDVGCYVGVGTEDYSENVGSRNATAFSATGTLQAFNSGRVSHHFGWTGPSVTVDTACSSAAVAIHLACQALQTSDCSVAVAGGVNVMTDPRWSQNLAAASFLSPTGASKAFDTNANGYCRGEGAGLVVLRPLEAALRDGDPIHAVITGTSVNQGANCSPITVPDSNSQRSLYMKALSLSGLKPEVVSYVEAHGTGTQVGDPIEFESIRKTFAVPSRTERLYVGSIKDNIGHTETSSGVAGLLKTILMLQKGKIPKQANFTQLNPKIIVNQEDQMSIPTSLIRWETQKRVAMVTNYGAAGSNAAIVLKEPIPTPTALCSDEKERLLSAVPFFVAAQTEESLREYCQALKARLLNGAHLESIAVQDLAFNLARKQNRSMEFSVSFTNSSSVTELRERLDDVISGRMNIVKKTHTSNPVVLCFGGQTGNKASISESLVASSALIRLHLDECESACKALGLPSLFPAIFDSSPNKDIVNLHCVLFSIQYATAKAWIDSGLEVDRMIGHSFGQLTAVCVAGGLSLIDTMRLISTRAHLIRSEWTSEIGVMLSLKGEKNAVRDLLDSVPDSADLACVNGADSFVAAGSEVAIHEIEKNAAERGIKSQRLDNTHAFHSRLVDPILPGLAKVASSLNYKPLRIPVEACSESKEDWMLPTWEKIVQHSRKPVYFHQAVHRTISRIQGPAIWLEAGTMSPIIGMVRRAVDTPSSARGHVFCPMDLSGPQAESNLAKVTSSLWSNGVPVQFWPFHGSQRGYQWINLPPYQFAKTSHWIEYDPTAFSYQMSKQEKPPIEDLKLVQLLKNEGKVSLFRINDNDPMFRMCTAGHAVVEQNLCPASLYFELVVRAAITTLPKGTDPTMYHLADLNISAPLVLDMPGSVLLELTQRDSTPGQWTFVLFTREDTLQSVTHATGTISLSPGADNTGISSRFSSLKRLLNPAHWDSIATSPSSSGLKRSTVYQAFRRAVTYAEYYRGVESVYALGHEATGRVHLPSSPTKNSPCDPILIDNFLQVAGIHVNCLSETHDDEVFVCSSVGDVIIGESFVKRDPSVAAPWVVYSNYEQESKKKALCDVFVVDEATGSLALCVLAATFTSVSIQSLRRTLTRLTNKGVSPVPVDIAVAAEVTPAVPAASSITATRASSNGDDLRTVQAMLSELLGIPTSEIPASASLADVGVDSLMNTEVLSEIKNRFQVVITKSELTAIEDVGALVQRIFPGRSTVHIENHDQPAVGITAINGGSKPSSGGPVPASKVGDDLSGFADKAGELFTASRKSNEHSEATKFLGFCDTVFPQQMELVTAYVVEAFKVLGVDLQSLKAGQPIPSVDILPQHGQVMNQLYAVLEYSGLVDRSGTSICRGHCEVNQDATAVLHQKILNDHPQHTSEHKLLHTTGPRLADCLTGAADPLSLLFQDAQARALMQDVYSNAPMFKSATMHLAQYLKNLLRQVNSPRPIKILEIGAGTGGTTDYLLKQLSSVAGLRFEYTFTDISPSLVTLARKRFKTFNFIHYQTLDIEKGPASEMLGQYDIIVSSNCIHATRSLSTSCSNIQKLLRPHGILCLIELTRNLFWFDLVFGLLEGWWLFNDGRSHALAHESFWDQTLRSSGFNWVDWTDNQSEESNILRLIVASPTRPALSLEATTESSAIHEETVVYGRKDGLDLLADIHYPQILDSEGKNRPVALLIHGGGHIMLSRKDVRPPQVKLLIDMGFLPVSIDYRLCPEVSLLEGPMADACEALAWAQNTLPQLNLQRPDIRPDGNNVVAVGWSSGGHLAMTLAWTAPARGLRAPEAVLSFYCATDYTDPFWTKPNFPYQGDVSIEDVPTQSPFLGINDRAITSYNPAPRKRALGGWMSPTDPRSRIALHMNWTGQTLTVLFNGHKYKSLVAIAGGDDNVILPKPTLSEIQKACPLSHVYAGQYKTPTFIIHGTLDDLIPVEQSQRTHDQMLANGVESELRVVADAPHLFDMSPNLKNNKDACRAVADGYEFLRSHVGL
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster A that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Non-reducing polyketide synthase ausA, Austinoid biosynthesis clusters protein A.