PharMolix/UniProtQA huggingface dataset:
Protein: IF2_BACAA
Sequence: MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKKGKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIEVEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVELNDKKITFLDTPGHAAFTTMRARGAQVTDITIIVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVPEAWGGDTIFVPISAIQGEGIDNLLEMILLISEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTSFGRVRAMVSDIGRRVKVAGPSTPVEITGLNEVPQAGDRFMAFADEKKARQIGESRAQEALLAQRGEKSKLSLEDLFQQIQEGDVKEINLIVKADVQGSVEAMAASLRKIDVEGVKVKIIHTGVGAITESDIILASASNAIVIGFNVRPDVNAKRTAELENVDIRLHRIIYKVIEEIEAAMQGMLDPEFEEKVIGQAEVRQTFKVTKVGTIAGCYVTDGKITRDSGVRIIRDGVVIFEGQLDTLKRFKDDVKEVAQNYECGITIERYNDLKEGDIIEAYIMEEVKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POL_HV1Z6
Sequence: IPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
What is the function of this protein?
Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.  This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA.  The first step in the integration process is 3' processing.  This step requires a complex comprising the viral genome, matrix protein, Vpr and integrase.  This complex is called the pre-integration complex (PIC).  The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends.  In the second step, the PIC enters cell nucleus.  This process is mediated through integrase and Vpr proteins, and allows the virus to infect a non dividing cell.  This ability to enter the nucleus is specific of lentiviruses, other retroviruses cannot and rely on cell division to access cell chromosomes.  In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration.  The 5'-ends are produced by integrase-catalyzed staggered cuts, 5 bp apart.  A Y-shaped, gapped, recombination intermediate results, with the 5'-ends of the viral DNA strands and the 3' ends of target DNA strands remaining unjoined, flanking a gap of 5 bp.  The last step is viral DNA integration into host chromosome.  This involves host DNA repair synthesis in which the 5 bp gaps between the unjoined strands are filled in and then ligated.  Since this process occurs at both cuts flanking the HIV genome, a 5 bp duplication of host DNA is produced at the ends of HIV-1 integration.  Alternatively, Integrase may catalyze the excision of viral DNA just after strand transfer, this is termed disintegration.
What are the official names of this protein?
Gag-Pol polyprotein, Pr160Gag-Pol.
Protein: FLGH_ALIF1
Sequence: MKRLLCLLLLTTLTGCETLLIKNPSAQESEVTSATTNVDAVEGDKAKEEDSGIIDTLRGRNDPIAGDPAWAPIHPKEKPEHYAAATGSLFNVDHAQDMYDDTKPRGLGDIVTVMLAENTKAAKSADAELSKSNDSSMDPLQVGGQELQMGGQYNFSYELSNDNNFTGNTSANQSNSLSGSITVEVIEVLSNGNLLIRGEKWLTLNTGDEYIRLSGTIRPDDINFDNTIDSTRISNARIQYSGTGDQQDMQEPGFLARFFNVAL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: CLCG_ARATH
Sequence: MPNSTTEDSVAVPLLPSLRRATNSTSQVAIVGANVCPIESLDYEIAENDFFKQDWRGRSKVEIFQYVFMKWLLCFCIGIIVSLIGFANNLAVENLAGVKFVVTSNMMIAGRFAMGFVVFSVTNLILTLFASVITAFVAPAAAGSGIPEVKAYLNGVDAPEIFSLRTLIIKIIGNISAVSASLLIGKAGPMVHTGACVASILGQGGSKRYRLTWRWLRFFKNDRDRRDLVTCGAAAGIAASFRAPVGGVLFALEEMSSWWRSALLWRIFFSTAVVAIVLRALIDVCLSGKCGLFGKGGLIMFDVYSENASYHLGDVLPVLLLGVVGGILGSLYNFLLDKVLRAYNYIYEKGVTWKILLACAISIFTSCLLFGLPFLASCQPCPVDALEECPTIGRSGNFKKYQCPPGHYNDLASLIFNTNDDAIKNLFSKNTDFEFHYFSVLVFFVTCFFLSIFSYGIVAPAGLFVPVIVTGASYGRFVGMLLGSNSNLNHGLFAVLGAASFLGGTMRMTVSTCVILLELTNNLLLLPMMMVVLLISKTVADGFNANIYNLIMKLKGFPYLYSHAEPYMRQLLVGDVVTGPLQVFNGIEKVETIVHVLKTTNHNGFPVVDGPPLAAAPVLHGLILRAHILTLLKKRVFMPSPVACDSNTLSQFKAEEFAKKGSGRSDKIEDVELSEEELNMYLDLHPFSNASPYTVVETMSLAKALILFREVGIRHLLVIPKTSNRPPVVGILTRHDFMPEHILGLHPSVSRSKWKRLRIRLPFFS
What is the function of this protein?
Putative voltage-gated chloride channel.
What are the official names of this protein?
Putative chloride channel-like protein CLC-g, CBS domain-containing protein CBSCLC6.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NHAB_ECODH
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRHQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYM_PSEAE
Sequence: MSEPRKILVTSALPYANGSIHLGHMLEYIQTDMWVRFQKMRGNQAVYVCADDAHGSAIMLRAEREGITSEQLIDAVRAEHMGDFADFLVDFDNYHSTHSEENRELSSAIYLKLRDAGHIDTRPVTQYFDPEKQMFLADRFIKGTCPKCGTADQYGDNCEACGATYAPTELKDPKSAISGATPVLKESLHYFFKLPDFEAMLKQWTRSGALQESVANKLAEWLDSGLQQWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMASFKNLCARRPELDFDAFWGKDSGAELYHFIGKDIVNFHALFWPAMLEGAGYRKPTALNVHGYLTVNGQKMSKSRGTFVKARTYLDHLDPEYLRYYYASKLGRGVEDLDLNLEDFVQKVNSDLVGKVVNIASRCAGFIHKGNAGVLVGADPAPELLAAFREAAPGIAEAYEARDFNRAMREIMALADRANAWIAEQAPWALAKQEGQQDKVQAVCGLGINLFRQLVIFLKPVLPKLAAAAEAFLNVAPLTWADHQTLLANHQLNPFQPLMTRIEPAKVEAMIEASKEDLAAASQPAGNGELVKEPIAAEIDFDAFAAVDLRIALIEKCEFVEGADKLLRLSLDIGDAKRNVFSGIKSAYPDPSALEGRLTLYVANLAPRKMKFGVSEGMVLAAGPGGEEIYLLSPDSGAKPGQRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_SHESM
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGVITEANGKIHRLEDWGRRQLAYPIQDLHKAHYVLMNVEAPAETIEELETAFRFNDAVLRNMVMRTKVAVTEASPMAKAKDERDSRRGPAGDRSYDEANAEEIAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PYRC_BACMK
Sequence: MNYLFKNGRYMNAEGTIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCKEHMEDLQKRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRASKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAANCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLTEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIAWQKESALV
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: SYC_SHEPW
Sequence: MLKLYNTLTRQKEQFVPIQPGKIGMYVCGVTIYDLCHIGHGRTFVSFDMIVRYLRYSGYEVNFQRNITDVDDKIIKRANENNESCDSLTERLIGEMHRDFDSLNMARPDFEPRATLHMPEIIEMVEKLIAREHAYVAANGDVLFSVSSFPEYGRLSGQNLEQLQAGARVEVEDAKRDPMDFVLWKMSKPGEPTWDSPWGPGRPGWHIECSAMNSKHLGNHFDIHGGGSDLQFPHHENEIAQSCCAHDTKYVNYWMHTGMVMVDKEKMSKSLNNFFTIRDVLNHYDAATVRYFLLSGHYRSQLNYSEENLKQAKSGLERIYTALKDLDLTVDAAPAEAFIAQFKRAMDDDFNTPEAYSVLFEMVREINRLKLTDMQQASALGVALKQLADVLGILGQDVDTFFKGEGSDDEVAEIEALIVERNRARTEKDWPAADVARDGLNALGVILEDGPEGTTWRKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGNS_REOVL
Sequence: MASSLRAAISKIKRDDVGQQVCPNYVMLRSSVTTKVVRNVVEYQIRTGGFFSCLAMLRPLQYAKRERLLGQRNLERISTRDILQTRDLHSLCMPTPDAPMSNHQAATMRELICSYFKVDHTDGLKYIPMDERYSPSSLARLFTMGMAGLHITTEPSYKRVPIMHLAADLDCMTLALPYMITLDGDTVVPVAPTLSAEQLLDDGLKGLACMDISYGCEVDASNRSAGDQSMDSSRCINELYCEETAEAICVLKTCLVLNCMQFKLEMDDLAHNATELDKIQMMIPFSERVFRMASSFATIDAQCFRFCVMMKDKNLKIDMRETMRLWTRSALDDSVVTSSLSISLDRGRWVAADATDARLLVFPIRV
What is the function of this protein?
Protein that binds to ssRNA and may be involved in genome packaging.
What are the official names of this protein?
Protein sigma-NS, SigmaNS.
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus sigma-NS protein family.
Protein: KAD_SERP5
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKEIMDAGKLVTDELVIALVKERITQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDATGEDLTTRKDDQEETVRKRLVEYHQMTAPLISYYSKEAAAGNTQYRKIDGTRKVTEVSAELATILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHIP1_ARATH
Sequence: MVLSNKKLKQRIRQDLAESLSVSVSETNPQSQSLKLLLDSSSHKPRLSKREKRRNCETFAREDDEIRENEVGNGGSSEKTDTKIKKKRKRDDAVEVDELEGDEGTKEEQKPQKKKNKKKKKKRKVNKTPKKAEEGNVEEKVKVEEIEVNTDNKEEDGVVPNKLYVGGIPYQSTEDEIRSYFRSCGVIIKVDCKMRPEDGAFSGIAFITFDTEDGAKRALAFDRAAMGDRYLTIQQYVKTTTPSIPRRKTSSGFAPEMVDGYNRVYIGNLAWDTTERDIRKLFSDCVINSVRLGKNKETGEFKGYAHVDFKDSVSVAIALKLDQQVICGRPVKICCALKDRPATDHTPGETNNAGSYNMEDTYAAADPVPALAGRSEVDDGNYFATTVSSSKVKRRVCYECGEKGHLSTACPIKLQKADDQANSKLGQETVDGRPAMQSYGLPKNSGDSYYMNETYASTNETYNGGYSASAVGTGKVKRRNCYECGEKGHLSTACPIKLQNTSHTNSTLDHQTVEAGPTQVTSYSLQKKTRDTENNGGSFMDESYATVPISIDVTNGANDASLTSAVSTGKIKKRNCYECGEKGHLSSACPNKLQKQG
What is the function of this protein?
RNA-binding protein which mediates polarized mRNA (e. g.  Ran2 transcripts mRNA) transport from the nucleus to the vicinity of the cell plate during cytokinesis and phragmoplast formation.
What are the official names of this protein?
Phragmoplastin interacting protein 1.
What are the subcellular locations of this protein?
Nucleus. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, phragmoplast. Note=Associates with the forming cell plate during cytokinesis; may shuttle between the nucleus and the forming cell plate.
Protein: HN_PI3HU
Sequence: MEYWKHTNHRKDAGNELETSMATHGNKLTNKITYILWTIILVLLSIVLIIVLINSIKSEKAHESLLQDINNEFMEITEKIQMASDNTNDLIQSGVNTRLLTIQSHVQNYIPISLTQQMSDLRKFISEIIIRNDNQEVPPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLTMPTTVDGCVRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENVICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSIPKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSVILDSQKSRVNPVITYSTATERVNELAIRNKTLSAGYTTTSCITHYNKGYCFHIVEINHKSLDTFQPMLFKTEVPKSCS
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Protein: RL9_RICCK
Sequence: MEIILIKPVRKLGKIGDILKVADGFGRNYLLPQKLAIRATEPNKELIVKQKHEFEAKDKQIREEVEKINALIKEQKLVFIRQTSDDGKLFGSITNKEIADKLSENVSYNIFHSNIILDKKIKSTGIYTVEIRLHAELNAIVTVIVARSESEVQDYLREQKNESLETLAESA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: FBK98_ARATH
Sequence: MSSPEKKRKTTKKPSPTPQSTTPNPSLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTRSLLGRTESCLYVCLQEKDSDPNPRWFTLCLKPNRTLTNDITEKKKKKKKKKKMSSGYVLAAIPVLHSRPAYWSGLVAVGSNIYNIGGPIDKAHSSIVSVLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDCSNSSNWMEVFDPRTQTWESVSSPGAEIGGCSIHKSAVVEGEILIANSHGLIYKPKEGRWERMKWDMDIGWVWYSYCVVENVLYYYYKGVFKWYDTMARLWRDLKGVKGLPRFARCGGKMADYGGKMAVFWDKIVTSDDGCKNKMILCAVIALERRNSEEIWGKVEWHDAVLTVPLSYEVVYALSPTV
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
F-box/kelch-repeat protein At4g39550.
Protein: RL15_MYCMM
Sequence: MTIKLHDLRPAPGSKTPRTRVGRGEGSKGKTAGRGTKGTKARKQVPTTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDIARLFPEGGTVGVDELVAKGAVRKNSLVKVLGDGKLTVKVDVTAHKFSGSAREQITAAGGSVTEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: BTBDH_HUMAN
Sequence: MPRRGYSKPGSWGSFWAMLTLVGLVTHAAQRADVGGEAAGTSINHSQAVLQRLQELLRQGNASDVVLRVQAAGTDEVRVFHAHRLLLGLHSELFLELLSNQSEAVLQEPQDCAAVFDKFIRYLYCGELTVLLTQAIPLHRLATKYGVSSLQRGVADYMRAHLAGGAGPAVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWLGRARPPPAVAERALRAIRYPMIPPAQLFQLQARSAALARHGPAVADLLLQAYQFHAASPLHYAKFFDVNGSAFLPRNYLAPAWGAPWVINNPARDDRSTSFQTQLGPSGHDAGRRVTWNVLFSPRWLPVSLRPVYADAAGTALPAARPEDGRPRLVVTPASSGGDAAGVSFQKTVLVGARQQGRLLVRHAYSFHQSSEEAGDFLAHADLQRRNSEYLVENALHLHLIVKPVYHTLIRTPK
What are the official names of this protein?
BTB/POZ domain-containing protein 17, Galectin-3-binding protein-like.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAG_BUCBP
Sequence: MPSLIPKEFINELIFKTNIIDIINTRLPLKKVGKNYNTHCPFHQEKTPSFTVNFEKQFYFCFGCNTHGNIIDFLMNYEQLTFVESIKELAKIHGLTIPCKNINKEKLFNYEKITNLYLLTKNIADLYHRNIFKTEYAYQYILNRGIDKSMIKYFNLGFSPKNWYDLEKKNKKQCYNQKELQEIGILKTTILGYTYDRFKNRIIFPIRNKNGNIVGFGGRTLNNHIPKYINSPETQIFHKGFQLYGLYEMLKTNPKPKQILIVEGYVDVIALVQFKINYTISTLGTIISNEQIKLLFRTSNTIIFCYDGDVSGQKAAWRTLNISLSHIHDGKNVKFIFLPNNEDPDSIIRKEGHDNFKIRIKKSIDFSKFLLQTLFKKTDLNSISEKSHTSTIAISLIRKIPGKITQTYLFQTLSKKIGILDYHVLINNNINNINTKIYTKKPIKKTTIRIVIALLIQNPWLALTLPSLKHLQNYKIIGLSCFLDLVEKCISMPNSNTGQILEKYRNKNIFKHLANLAKWDHMIHNEKIKDFFLDSLTKICDIILEDRQNKLISQERLNGLNKQEKYELWSINKELAKK
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: FBW1A_MOUSE
Sequence: MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMKTENCVAKAKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAEPPRSPSRTYTYISR
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10097128, PubMed:16371461, PubMed:18782782, PubMed:9859996, PubMed:9990853, PubMed:21911472, PubMed:29593216).  Recognizes and binds to phosphorylated target proteins (PubMed:10097128, PubMed:16371461, PubMed:18782782, PubMed:9859996, PubMed:9990853, PubMed:21911472).  SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2.  SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity).  SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:9859996, PubMed:10097128).  Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:9859996, PubMed:10097128).  SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity).  SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (PubMed:21911472).  Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:18782782).  May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase (By similarity).  Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF (By similarity).  Required for proteolytic processing of GLI3 (PubMed:16371461).  Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (By similarity).  SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216).
What are the official names of this protein?
F-box/WD repeat-containing protein 1A, Beta-TrCP protein E3RS-IkappaB, Beta-transducin repeat-containing protein, Beta-TrCP, E3RSIkappaB, mE3RS-IkappaB, F-box and WD repeats protein beta-TrCP, HOS, Ubiquitin ligase FWD1, pIkappaB-E3 receptor subunit.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PNDA1_ECOLX
Sequence: MPQRTFLMMLIVVCVTILCFVWMVRDSLCGFRIEQGNTVLVATLAYEVKR
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (By similarity).  Toxic component of a type I toxin-antitoxin (TA) system (By similarity).  When expressed is involved in cellular Mg(2+) release and degradation of stable RNA (PubMed:2465777).
What are the official names of this protein?
Protein PndA.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IF2_LACLC
Sequence: MSDKKRINQIAKETGLSNTELVATAQSLGFEVKSHSSSVTAEQAEKIIQGVKTGTDTIVNLLKKLLKLKLRLVPETAKSKQEDHPRTFAGKAVVEDPAILARIKEKEEAKKAAKTEAEPIEEVITTEKPKVAEPVKKSEPKAAAKAEETKVEKVEAKANTVTPKAEVKTENVADKKEPVVTEEKKKSLTQKPRIQIKVIKRAEDIKKEQAAARPEKKKFDKNRNDRNNRNDNRRPNQNGNGQGHSQGGNHYDKNRPAGQGQNQGQKRDKFASSGSSSTSDTFTPAASGKNNRRDRDRKKTDSNRDNTKDGNRKGGPLRVNDNRNQVRNARNSNWNQKGGRGRYQNNQSSNVPATQRKFHELPESLEYEVGMNVQDIAKSIKREPAEIIKKLFMMGTMVNQNQSLDEDTIELILMDYGVTPLKKVEEDKSDIERLFVEDGYLNEDKMVERPAVVTIMGHVDHGKTTLLDRFRESRVTEGEAGGITQHIGAYQIKTNGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAAGVPIIVAINKLDKPGANPQRVTQELTEHGVFPVAWDPENGSEFVEISAKFNQNLEDLLDTVLLVAEVQELKADPSVRAIGTVVEARLDQGKGAIATLLVQQGTLHIQDPIVVGNTYGRVRTMTNDLGRRIKEAGPSTPIELTGLSDVPQAGDHFAVFEDEKAARAAGEERAKRAQLIKRQNTRRVNLDNLFDTLKEGQTKSVNIIIKADVQGSAEALAASLQKIEVEGVKVDIVHSAVGAISESDISLAAASNAIIIGFNVRPTGLAREQAAQEEVDIRLHSIIYKVIEEVETAMHGMLDPEFKEEIIGEAIVRETFNVSKVGTIAGFMVIRGKVTRDASVRVIREGVVIHDGAIASLKHFKDDVKEVGNAQEGGLMVEDFNDVEIDDTFEVYKMVEIERKK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPP3_ENTH1
Sequence: MFALILFVSLACANEVAFKQWAATHNKVFANRAEYLYRFAVFLDNKKFVEANANTELNVFADMTHEEFIQTHLGMTYEVPETTSNVKAAVKAAPESVDWRSIMNPAKDQGQCGSCWTFCTTAVLEGRVNKDLGKLYSFSEQQLVDCDASDNGCEGGHPSNSLKFIQENNGLGLESDYPYKAVAGTCKKVKNVATVTGSRRVTDGSETGLQTIIAENGPVAVGMDASRPSFQLYKKGTIYSDTKCRSRMMNHCVTAVGYGSNSNGKYWIIRNSWGTSWGDAGYFLLARDSNNMCGIGRDSNYPTGVKLI
What is the function of this protein?
Cysteine protease which may be involved in pathogenicity.
What are the official names of this protein?
Cysteine proteinase 3, EhCP3, Cysteine proteinase ACP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: CSOS1_PROMA
Sequence: MANETMGIALGMIETRGLVPAIEAADAMTKAAEVRLIGREFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARPHREVEPALGNGNFLGQKD
What is the function of this protein?
One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered.  Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome.
What are the official names of this protein?
Carboxysome shell protein CsoS1.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.