PharMolix/UniProtQA huggingface dataset:
Protein: API2_SOLTU
Sequence: MMKCLFLLCLCLLPIVVFSSTFTSQNLIDLPSESPLPKPVLDTNGKELNPNSSYRIISIGRGALGGDVYLGKSPNSDGPCPDGVFRYNSDVGPSGTFVRFIPLSGGIFEDQLLNIQFNIATVKLCVSYTIWKVGNLNAYFRTMLLETGGTIGQADSSYFKIVKLSNFGYNLLYCPITPPFLCPFCRDDNFCAKVGVVIQNGKRRLALVNENPLDVLFQEV
What is the function of this protein?
Inhibitor of cathepsin D (aspartic protease).  May also inhibit trypsin and chymotrypsin (serine proteases).  Protects the plant by inhibiting proteases of invading organisms.
What are the official names of this protein?
Aspartic protease inhibitor 2, CathIhn, Cathepsin D inhibitor, CathDinh.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Vacuole.
Protein: ARLY_LIMRJ
Sequence: MPIKRMWGGRFEEAGDQLVNQFNASISFDQEMAQEDIEGSLAHVKMLKETQILSAEDADKIIAGLKKLRERLTSEGLPFSIDNEDIHMNIEALLTEEIGPVAGKLHTGRSRNDQVATDLHLYVKKRLPIIINELKKLQAELVDKAAENVETIMPGYTHMQHAQPISYGHYLMAYFQMFQRDVERFEFNQQHTDLSPLGAAALAGTTFPIDRQLSAKYLGFAGPYHNSLDAVSDRDFALEFLSNASILMMHLSRLCEELIYWCSYEFGYLELADSYSTGSSIMPQKKNPDMAELIRGKVGRVYGDLFSLLTTMKGLPLAYNKDMQEDKEGLFDAVKTILPSIKIMTGMIATLQVKKEAMEHATHHDFSNATELADYLATKGIPFREAHEIVGELVLKGLKTGTNLVDIPLDEYKKISPKIEEDVYTCLQPKVAVERRNSYGGTGFDQVRQQIKDAKKILEGK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_SERP5
Sequence: MATYSSNDFRPGLKIMFEGEPYAIESSEFVKPGKGQAFARVKMRRLLTGSRVEKTFKSTDSCEGADVVDTNMNYLYNDGEFYHFMHPETFEQHGVEEKTVSDAAKWLQDNAECIVTLWDGRPIAVQPPNFIEAEITDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVVRVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCA_TREDE
Sequence: MAVINVTSEIGKLKKVLLHRPGKELLNLTPDKLDELLFDDIPFLKMAQKEHDAFADILSKNGVEVVYLEDLAAEAVSQSAEIREKFIKQYINEADIYSEYYQKMIYDFLNAIKDPKELILKTMEGVNANEIPFKNTHSLSHYVLDSGSMVINPMPNLYFTRDPFACIGNGVSLNKMYSVTRCRETIYGEYIFDHHPEYAGKVNRFYNRYDAPSIEGGDILNIGKDVLAIGLSQRTSANAIDSIANNIFDNETSPIKTVLAFQIPAIRAFMHLDTVFTQIDFDKFTIHPGILGPLRVFEITRGTKKGELNVKQIDSTLEKVLEKYTGAGKIELIQCAGGDKIAAEREQWNDGSNTLCISPGTIVVYERNDVTNEILNKKGLKVLEMPCGELSRGRGGPRCMSMPLLREDIR
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRP11_MOUSE
Sequence: MATRGGGPGPGFRHRALRGLLLLCLWLPGSRPGEPAAPSSGVDRLLQDFRRQLQRARPREELEPELLGGPREDCPGAGGTAVYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVPAPMPAPRCYLFNCTARGRSVCKFAPLRGYRTYTLSRAEDAAGIPPRPDEDKPPVSKAGKDVVLHLPTDGVVLDGRESSDDHAIVLYEWTLQQGDPSSVDMKVPQPGTLRLSRLKEGAYIFQLTVTDSVGQRSSDNVSVTVLPRPYSTGGCSSACSRYHFFCDSGCCIDIALACDGVRQCPDGSDEDFCQNLALDRKLVTHTVATSAQPGAMGLNEGEGDPKLEKSQRATTHNQPATVSHPETRIHSTQKAPESQINPVQPDSNSSGKNQEEGNYDLKSKSGQAGGEHPAPEAGAVLPLALGLAITVLLLLMVTCRLRLVKQKLKKARPITSEESDYLINGMYL
What are the official names of this protein?
Low-density lipoprotein receptor-related protein 11, LRP-11.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL31B_HALH5
Sequence: MKPGIHPDYKKVVFMDTSTGFKFLSGSTKTSNETIEWEDGNTYPLIKVEISSDSHPFYTGKQKLADAGGRVDRFKKKYNLK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: GREA_STAA1
Sequence: MENQKQYPMTQEGFEKLERELEELKTVKRPEVVEKIKVARSFGDLSENSEYDAAKDEQGFIEQDIQRIEHMLRNALIIEDTGDNNVVKIGKTVTFVELPGDEEESYQIVGSAESDAFNGKISNESPMAKALIGKGLDDEVRVPLPNGGEMNVKIVNIQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: ATP6_DUGDU
Sequence: MNENLFTSFITPTMMGLPIVILVIVFPAMLYPSPNRLINNRLISIQQWLVQLILKQMLLIHNSKGRTWALMLISLILFIGSTNLLGLVPYTFTPTTQLSMNLGMAIPLWAGAVITGFRHKAKASLAHFLPQGTPITLIPMLVVIETISLFIQPMALAIRLTANITAGHLLMHLIGGAVLALTSISPAAATITFIILLLLTILEFAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PSTP_MYCTU
Sequence: MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
What is the function of this protein?
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling (PubMed:14575702, PubMed:12950916, PubMed:27758870).  May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell (PubMed:31958639).  Plays a role in establishing and maintaining infection (PubMed:27758870).  Dephosphorylates several proteins, including the kinases PknA, PknB, PknD, PknE, PknF, PknH, PknJ and Pyk, the transcriptional regulatory proteins EmbR and EthR, the osmosensory protein OprA and the dimycocerosyl transferase PapA5 (PubMed:14575702, PubMed:12950916, PubMed:15967413, PubMed:16817899, PubMed:17411339, PubMed:19826007, PubMed:20520732, PubMed:21423706, PubMed:31958639).  In vitro, dephosphorylates the phosphorylated Ser/Thr residues of myelin basic protein (MBP), histone and casein phosphorylated at Ser/Thr residues, but fails to dephosphorylate phosphotyrosine residue of these substrates (PubMed:14575702, PubMed:12950916).
What are the official names of this protein?
Serine/threonine protein phosphatase PstP, Mycobacterial Ser/Thr phosphatase, Mstp, PP2C-family Ser/Thr phosphatase.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RF1_MESM1
Sequence: MEDTLYKSLKSIKEKYDSNEKKLLLPEVFNNIKEYTKISKENNSISEIVENFNKFLINEQTIKDAKILLDEKDEEMVSFAKNEIHKSELENQELEKKLRILILPKDENDERNVIIEIRGAAGGDEANIFAGDLLKMYNKWADINKMKLKLLDYANASSGGFSQVTFLVEGDKAYSKLKFESGVHRVQRIPVTETQGRVHTSTTTVTVMPEVDDVAEVEINPVDLKIDTFRSSGPGGQSVNTTDSAVRITHLPSGIVVSSQDEKSQISNRESALKILKSKLYDLEIKKRNEETGKFRKLAGSGARSEKIRTYNYPQDRITDHRIGFSTSLKIAMEGKINNIIEALHAEEQAEKIKEANL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
Protein: ZN436_HUMAN
Sequence: MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD
What is the function of this protein?
May be a transcriptional repressor.
What are the official names of this protein?
Zinc finger protein 436.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TGT_PROMP
Sequence: MFEFEIKSNCSNTEARTGIFHTPNGQVNTPRFMPVGTLATVKGISSEQLISTGSEMILSNTFHLHLQPGEKLVKESGGIHKFMNWDKPILTDSGGYQVFSLAKLNNISDKGVEFRNPRDGSHVFLSPEKVMQIQMDLGSDVAMAFDHCPPHTANENDIEDSLERTHSWLQKCVETHQKSNQALFGIVQGGKYPRLREHSAKFTSSFDLPGIAVGGVSVGEAVEEIHSVINNVPKFLPINKPRYLMGIGSLREISLAVAKGFDIFDCVLPTRLGRHGTAFFNDERWNIRNARFKNDFSPIDKTCKCETCKSYSRAYLHHLVRNDEILGLTLISLHNISHLIRFTNAISAAIKDNCFTIDFAPWKRSSIAHHTW
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: AROC_FRATW
Sequence: MSGNTFGKIFTVTTCGESHGDSLAAIIDGCPSNIPLCEADIQLELDRRKPGQSKFTTQRKEPDEVKIISGVFEGKTTGTPIGLIIKNQDQKSKDYSEIKDKFRPGHADYTYFKKYGIRDYRGGGRSSARETAMRVAAGAIAKKILKHYGIEIYGFCSQIGSLKIDFIDKDFINQNPFFIANKNAVPACEDLIHSIRKQGDSIGAEVTVVATGLEAGLGRPVFDRLDASIAYAMMSINAVKAVSIGDGFDCVAQKGSQHRDEITQQQGFLSNHAGGILGGISTGQDIIAKLAFKPTSSILQPGKSIDVQGNDTTVITKGRHDPCVGIRGVPIAEAMLALVLVDELLITRSYRD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PACC_CANDC
Sequence: MNYNIHPVTYLNADSSNTGTAETTTQHHHGSKKSPSSDIDVDNATSPSSFTSSQSPHINAMGNSPHSSFTSQSAANSPITDAKQHLVKTTTNEHKPAAFTPSVGQQPASQTNTTAPQSYTQPAQQLPTQLHPSLNQVYNNQPSYYLHQPAYGYQQQPLHQEYNQQPQQYHDHHGYYANNNNIPSINELNQKPPAPVKPFKKTYKKIRDEDLKGPFKCLWSNCNIIFETPEILYDHLCDDHVGRKSSNNLSLTCLWENCGTTTVKRDHITSHLRVHVPLKPFHCDLCTKSFKRPQDLKKHSKTHAEDHPKKLKKAQRELMKQQQKEAKQQQKLANKRANATTASDLQLNYYSGNPGDGLYDEASRKRRYENNSQHNMYVVNSILNDFNFQQMAQPPQQPGAVSTAVSSEFTTKRMKSGSEYNIDVFNKLNHLDDHLHHHHPQQNPQQYGGNIYEAEKFFNSLSNSIDMQYQNMSSQYQQQNPGVASFAQQKPAQQTNGQLYPSLPTIGNGSYTTSSSSSHKEGLVNNHNGYLPSYPQINRSLPYSGVAQQPPSALEFGGVSTYQKSAQSYEDSSESSDDDDDDEDDDDYSTSSEEELDALFDKLNIVDKNVEEVTIDGFNLKDVAKHRDMIHSVLVYLRKQIEQQEKEKSQEQKDDVNQLYPTITAF
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes (By similarity).
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSBM_OLTVI
Sequence: MEVNILGLIATALFILIPTSFLIILYVKTEAVNDM
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS10_BOVIN
Sequence: MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
What is the function of this protein?
Component of the 40S ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS10 family.
Protein: AC4CH_YERPS
Sequence: MNREITFFGRFEADILADRKTITIRDSSESDFRSGEVLRVCRNEDGVFFCHIKVKSVTPVTLDGLSERHAEQENMSLDELKKVIKAIYPGLDRFYVIEFTRC
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: VFE66_ASFWA
Sequence: MLKYIYMHLSHKYNHILFTYNTRIIS
What are the official names of this protein?
Uncharacterized protein E66L, pE66L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus E66L family.
Protein: STAR7_HUMAN
Sequence: MLPRRLLAAWLAGTRGGGLLALLANQCRFVTGLRVRRAQQIAQLYGRLYSESSRRVLLGRLWRRLHGRPGHASALMAALAGVFVWDEERIQEEELQRSINEMKRLEEMSNMFQSSGVQHHPPEPKAQTEGNEDSEGKEQRWEMVMDKKHFKLWRRPITGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDVVSGSEVLHWVTHFPYPMYSRDYVYVRRYSVDQENNMMVLVSRAVEHPSVPESPEFVRVRSYESQMVIRPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIKVKDYISAKPLEMSSEAKATSQSSERKNEGSCGPARIEYA
What is the function of this protein?
May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
What are the official names of this protein?
StAR-related lipid transfer protein 7, mitochondrial, Gestational trophoblastic tumor protein 1, START domain-containing protein 7, StARD7.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GATC_AGRVS
Sequence: MSVDLATVKRVAKLARIALPEDEAERVMGELNGILGFVEQLSEVNVDGVEPMTSVMPMAMRKRKDAVTDGGKADDIVANAPETDRHFFLVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: CYSD_XANC5
Sequence: MTLPPLSHLDRLEAESIHILREVAAEFRAPVMLYSVGKDSSVLLHLLLKAFAPSRPPIPLLHIDTRWKFREMIAFRDRRAAETGVDLRVHINPDGVAQDVGPISHGAAVHTDIMKTQGLKQALEHGGFDAAIGGARRDEEKSRAKERVFSFRTARHRWDPKNQRPELWNLYNARTGPGESVRVFPLSNWTELDIWLYIYREKIPVVPLYFAAPRPVVERDGAWIMVDDARLPLRPGETPQLRSVRFRTLGCYPLTGAIDSDADTLEAVIAEMLVSTSSERQGRMIDHAPGASMEQKKLEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: E26_NPVAC
Sequence: MESVQTRLCASSNQFAPFKKRQLAVPVGSVNSLTHTITSTTVTSVIPKNYQEKRQKICHIISSLRNTHLNFNKIQSVHKKKLRHLQNLLRKKNEIIAELVRKLESAQKKTTHRNISKPAHWKYFGVVRCDNTIRTIIGNEKFVRRRLAELCTLYNAEYVFCQARADGDKDRQALASLLTAAFGSRVIVYENSRRFEFINPDEIASGKRLIIKHLQDESQSDINAY
What is the function of this protein?
Plays a role in the sorting of ODV envelope proteins to the host inner nuclear membrane.  May facilitate the fusion and release of nucleocapsids into the cytoplasm.  Modulates the expression levels of IE0 and IE1.
What are the official names of this protein?
Protein E26, Protein AC16.
What are the subcellular locations of this protein?
Host nucleus inner membrane. Virion. Host cytoplasm. Host nucleus. Note=Early in infection, localizes both in the host nucleus and cytoplasm while later in infection localizes in viral-induced microvesicles within the host nucleus.
Protein: PG057_VACCC
Sequence: MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLRSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
What is the function of this protein?
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell.  Produces the wrapped form of virus that is required for cell-to-cell spread.  Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities.
What are the official names of this protein?
Envelope phospholipase OPG057, 37 kDa protein, Envelope phospholipase F13, Envelope protein F13, Palmitoylated EV membrane protein, p37K.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG057 family.
Protein: MRAZ_PECCP
Sequence: MFRGATLVNLDSKGRLAVPTRYREMLNGESQGQMVCTIDLHQPCLLLYPLPEWEIIEQKLSRLSSMNPAERRVQRLLLGHASECQMDSAGRLLIANTLRQHADLKKEVMLVGQFNKFELWDEQTWYQQVRDDIDAEQSTQEPLSDRLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SELA_ECO57
Sequence: MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRGSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_COREF
Sequence: MAVKIKLQRLGKIRTPHYRVVVADARTKRDGKVIENIGIYEPKQDPSVIKIDSERAQYWLSVGAQPTESVAALLKVTGDWQKFKGIEGAEGTLRVAEEKPSKLDLFNQALSEANNGPTAEAITEKKKKAREEKEAKEAAEKAAAEKAAAAEAEASEEAPAEEAASEEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SAC8_ARATH
Sequence: MEIAPSTSRFKLYDQFELLEFPDKYVVKPIESPEEGFSVNRRDGNIKPLDENASSGSPTRVSTIYGVGGTIRLLAGTYLLVITSREEVGNFLGLPIFRVTAMKFLPCNEALRFATAQEKKDETYFRTLLQALETTPGLYFSYETDLTLNLQRRCKLAEGWNRKPMWKQADPRYVWNWHLLEDLIECKLDGFIIPILQGSYQVAELKLKNSPAVVSIMSRRCTRRLGTRMWRRGANLEGDAANFVESEQIVEINGFKFSLLQVRGSIPLLWEQIVDLSYKPRLKINKHEETPKVVQRHFHDLCQRYGEIMAVDLTDQHGDEGALSKAYATEMEKLPDVRYVSFDFHQVCGTTNFDNLGVLYEQIGDEFEKQGYFLVDADENILEEQKGVIRSNCIDCLDRTNVTQSFMGQKSLNLQLQRIGVCDSTECISTFEDDYTKFRTIWAEQGDEVSLQYAGTYALKGDLVRYGKQTMTGAIKDGLSAMSRYYLNNFQDGVRQDALDLISGRYTVGTHSPSQLQPIGSQPSFLPVASALLIGGVTVTSFTIHQAGRNTQQYLASALWAGVTAGVVAMIKANGRHLTSRPRLCHLI
What is the function of this protein?
Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P.
What are the official names of this protein?
Phosphoinositide phosphatase SAC8, AtSAC8, Protein SUPPRESSOR OF ACTIN 1A, AtSAC1a, Protein SUPPRESSOR OF ACTIN 8, Putative transmembrane protein G5p, AtG5, SAC domain protein 8, SAC1-like protein AtSAC1a.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EFTU_BIFLO
Sequence: MAKEKYERTKPHVNIGTIGHVDHGKTTLTAAISKVLHEEFPDVNPEYDFNQIDSAPEEAARGITINIAHIEYQTEKRHYAHVDCPGHADFVKNMITGAAQMDGAILVVAATDGPMAQTREHVLLARQVGVPKILVALNKCDMVDDEELIELVEEEVRDLLDENGFDRDCPVIHTSAYGALHDDAPDHEKWVQSVKDLMDAVDDYIPTPVHDLDKPFLMPIEDVFTISGRGTVVTGRVERGQLAVNTPVEIVGIRPTQQTTVTSIETFHKTMDACEAGDNTGLLLRGLGRDDVERGQVVAKPGSVTPHTKFEGEVYVLTKDEGGRHSPFFSNYRPQFYFRTTDVTGVIELPEGVEMVQPGDHATFTVELIQPIAMEEGLTFAVREGGHTVGSGRVTKILA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.