PharMolix/UniProtQA huggingface dataset:
Protein: BOL1_YEAST
Sequence: MFKRAMSTDGPVARTILKRLECGFPDYKNFAFGLYNDSHKHKGHAGVQGNVSAETHFRIEMVSKKFEGLKLPQRHRMVYSLLQDEMAQANGIHALQLSLKTPQEYESKAK
What is the function of this protein?
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH) (PubMed:27532772).  Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772).  Probably acts together with the monothiol glutaredoxin GRX5, earlier than BOL3 and NFU1 in the [4Fe-4S] cluster insertion process (PubMed:27532773).  Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772).
What are the official names of this protein?
BolA-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BolA/IbaG family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: WIPF1_HUMAN
Sequence: MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR
What is the function of this protein?
Plays a role in the reorganization of the actin cytoskeleton.  Contributes with NCK1 and GRB2 in the recruitment and activation of WASL.  May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation.  Plays a role in the formation of cell ruffles (By similarity).  Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
What are the official names of this protein?
WAS/WASL-interacting protein family member 1, Protein PRPL-2, Wiskott-Aldrich syndrome protein-interacting protein, WASP-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the verprolin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Protein: TORD_PSYWF
Sequence: MNNSQQWQAANTARAALYRWFAELFARELTKTNLTQLQAQYPSLHAAFSDLNLEPQSAALQTALENLQVIPAPDRALELAADFAHLFLLSGHQSAPPYASYYLESDQMLYGKPAQQMSEFLASHKLDLHPEFREPKDHLSIYLQVMSLWIKSSVDEQANLIEMAVQQQHFLEDALLSWLPKFAARCQHIRVKTQVYPAIIDLLLHFVQEDRQALEDMAEAE
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB1_FRATF
Sequence: MDQQAQPQFQIQKVYVKDLSFSIPNSDKIWTTNWKPELHTDLKVEATKLPEENTYETVLTLEVKVENDGMVAFEAEVKQAGIFTVANMQEAQIEHAKKAFCPNILYHYAREAISDLVISGGFPQLCLSAVNFDAMYQDSLKESADSKQH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB 1.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGGGP_METST
Sequence: MNPYIEILRPTNALMAFIAVLLMAIIGHTYNYEIILGSLCVFIATGSGNTINDYYDYEIDRINAPNRPIPSGKIELKRALYYSLILFLVSIILGFIISLENGIVVILCTILMIIYAYDLKQRCFIGNLCVAILTGLTFVFGGLITKDVNLGFILGFFAFLMTLSREIIKDIEDIEGDKKEDAHTLPIIYGTKKAVMLAVILNIITCILSPLLYYYNIFSIVYLIIIIIADIIFVYSAYLAVQNQSKESMHKISKYMKIGMLIAFVSFAMGAL
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXA_SYNFM
Sequence: MQIHPTAIVDSKAELADDVVIKAYSIIGPNVKIGPGTSVGPHAVIDGWTTIGARNQVCSFVAIGHPPQDFSYRDEETRVLIGDDNVFREHVSIHRGTRRGRGTTRVGSRNYIMSAAHIAHDCQIGDNVVMANVAVLGGHVEIGDFAALGGAVAVHQFVRIGTYSFIGGGSGISMDVPPYMLVVGSRPAKLYGLNTTGLKRHDFSANVLSALKKSYRILFRSGLNVRDAVDKIRVEVETCAEVELLLEFVGSSKRGVIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRO2_RABIT
Sequence: MAPAATAAAPRLLRAALLLLLLVAAGRRAAGAPVVNELRCQCLQTLQGIHLKNIQSVKVTTPGPHCDQTEVIASLKTGQEVCLNPTAPVVKKIIDKMLNKASAN
What is the function of this protein?
Plays a role in monocyte adhesion to the endothelium.
What are the official names of this protein?
Growth-regulated protein homolog, GRO homolog.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYE_MYCGI
Sequence: MKVRVRFCPSPTGTPHVGLIRTALFNWAYARHTGGDFVFRIEDTDAQRDSEESYLALLDALRWLGMDWDEGPEVGGPYAPYRQSQRRDLYLDVIRRLLAAGEAYEAFSTAEEVEARHLAAGRNPKLGYDNFDRDLTEEQRAAFRAEGRQPVVRLRMPDADMTWVDLVRGETTFPVGSVPDFALTRGSGDPLYTLVNPVDDALMKITHVLRGEDLLPSTPRQLALYAALIRIGVTDMTPQFAHLPSVLGEGNKKLSKRDPQSNLFLHRERGFIPEGLLNYLALLGWSIADDRDIFSVQEMVAAFDVADVNSNPARFDQKKADALNAEHIRRLDEAEFVRRLADYFSTHGYDTGLDDARFAEAAALVQTRIVVLGDAWDLLKFLDESSFALDEKSAGKELKDTAVPVLTAALAALKGVGEWTTAQIEDALKVALIDGLELKPRKAFGPVRVAVTGSSISPPLFESLELLGRDRSLERLRAGRDHAAAAVTMDA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S1PR4_MOUSE
Sequence: MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST
What is the function of this protein?
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).  S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.  May be involved in cell migration processes that are specific for lymphocytes (By similarity).
What are the official names of this protein?
Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Lysophospholipid receptor C1, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIG_MYCUA
Sequence: MKSSVEQLSPTRVRIKVEVPFAELEPDFQRAYKELAKQVRLPGFRPGRAPVKLLEARFGREAMLDQIVNDAVPSRYGQALAESEIQPLGRPDIEVTQKEYGQDLAFTAEVDVRPEIALPDLTGLSVSVDAIEATDDEVNAELESLRARFGTLTGVERPVATGDFISIDLSAAVDGEDVPNAAAEGLSHEVRSGRLIAGLDDAVVGLSVDESRVFTAKLAAGDHAGRDAEVTVTVKSVKERELPEPDDEFAQLASEFDTIDELRASLREQVLQAKRVGQAEQIRNATIDALLERVDVPTPESYVQAQYEGVLHSALSGINNDEARFNELLVEQGSSRDAFDAEARTASEKDVKRQLLLDALADDLKVQVGQEDLTERLVLTSRQYGIEPQQLFVYLQENNQLPSMFADVRRELAVKAVAQAATVTDTDGNTIDTSEFFGKPPENDVTDLLDDDADGDAGVDADGDTENSAEPADADSADTAQGAG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ACP7_HUMAN
Sequence: MHPLPGYWSCYCLLLLFSLGVQGSLGAPSAAPEQVHLSYPGEPGSMTVTWTTWVPTRSEVQFGLQPSGPLPLRAQGTFVPFVDGGILRRKLYIHRVTLRKLLPGVQYVYRCGSAQGWSRRFRFRALKNGAHWSPRLAVFGDLGADNPKAVPRLRRDTQQGMYDAVLHVGDFAYNLDQDNARVGDRFMRLIEPVAASLPYMTCPGNHEERYNFSNYKARFSMPGDNEGLWYSWDLGPAHIISFSTEVYFFLHYGRHLVQRQFRWLESDLQKANKNRAARPWIITMGHRPMYCSNADLDDCTRHESKVRKGLQGKLYGLEDLFYKYGVDLQLWAHEHSYERLWPIYNYQVFNGSREMPYTNPRGPVHIITGSAGCEERLTPFAVFPRPWSAVRVKEYGYTRLHILNGTHIHIQQVSDDQDGKIVDDVWVVRPLFGRRMYL
What are the official names of this protein?
Acid phosphatase type 7, Purple acid phosphatase long form.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM32_STRCO
Sequence: MRMSAPELIRIVSRDSPMALAQVERVRAELAALHPGVRTEVVPVRTTGDKWLGDLSQVEGKGAFTKEVDAALLSGEADLAVHCVKDVPADRPLPAGTVFAAFLKRDDVRDALVHPDGLTLDELPDGTRVGTSSVRRVAQLAATHPHLRCVPFRGNANRRLAKLAAGEADALLLAVSGLERIGRTDVISEVLSTETMMPPIGAGILALQCREGDRALIEAVSALGDPRTHREATAERMFLHVLQGHCNSPIAGHAQVDRSGELSLRACVFTPDGKVRLNAHEWAGRLDPATLGTSVAVALLRQGAREIIDGIAH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase 2, PBG 2, Hydroxymethylbilane synthase 2, HMBS 2, Pre-uroporphyrinogen synthase 2.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: S22A3_HUMAN
Sequence: MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
What is the function of this protein?
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707).  Cation cellular uptake or release is driven by the electrochemical potential, i. e.  membrane potential and concentration gradient (PubMed:10966924).  Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:12538837).  Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:10196521, PubMed:16581093, PubMed:20858707).  Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (PubMed:17460754).  May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924).  May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).  Mediates the transport of polyamine spermidine and putrescine (By similarity).  Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837).  Also transports guanidine (PubMed:10966924).  May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 3, Extraneuronal monoamine transporter, EMT, Organic cation transporter 3, OCT3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FIME_PORGN
Sequence: MKSKSIIAQLLYVLIAFMAVSCVADKSEPCPSGEPTRVSGSIVSLEHHGLRGASADKENSVERLELWVFDEDGHFLERAVADLSGSTFTAKIIPSEVERRIHFIANYELADPSVWVGRSEREMLPSISVADDLETIRMWARISYPSIAPNQNLGQIQLLRNMAKFSLSVTPPAESKLYDASYALYNSWNKGTLAPFDPNTGSFPQGQITEPAGVVFANPTSEAAFKEADGAHFFYGFERDQSNIGTGAGITCLILKARYNLPNADYTYYKLDFVDTNKVRYNITRNHFYKMILKKAKAPGRPTLQEALDGAAANNIFLSAEVQALPAFSDGSGMLTVDHTYMVFVQGEPSGTFQATYIPQGQNNPDYSKLTVSVSTPTGQQAAVTSAQHEGNGKIKLTLAQQENLTKRSDVVIGVQGNPDLKRSVTVLVREKYQYVFFKANTSSAENNQVTTQISAGQGNELLISAKLPDVLNAALLPITFKVYTEHFYPKTGGMILGIEGGKTLYKYVLTTMPQNKELQFRFKSNKVNSAENIAVKMDYFHDQTIHVTN
What is the function of this protein?
Probably a component of the fimbrium tip; required for incorporation of FimC and FimD into fimbriae.  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in invasion of periodontal tissues and are major virulence factors.  FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.
What are the official names of this protein?
Major fimbrium tip subunit FimE.
What is the protein family that this protein belongs to?
Belongs to the FimE family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable). Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE (By similarity).
Protein: RLMN_ECO8A
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSL31_DICDI
Sequence: MTIFSTISSMSNVSSSSKSKISLMANSNGGQSLNNISCGGCGGSSSGGIVYTGPSGRSYTLPELIAVGVAHTKAFLMGASGSGNCSC
What are the official names of this protein?
HssA/B-like protein 31.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: RS13_BRADU
Sequence: MARIAGVNIPTNKRVLIALQYIHGIGQKIAGEILEKVKIPVDRRVSQLSDAEVLQIREVIDRDYLVEGDLRREVGINIKRLMDLGCYRGLRHRRGLPVRGQRTHTNARTRKGPAKAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: EH1L1_HUMAN
Sequence: MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFIIENESKGQRKVLATAEVDLARHAGPVPVQVPVRLRLKPKSVKVVQAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEDEAHGPGAPEARARVPQPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAPAPPARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALEKEAARSRVLESEVAGTAQCEGLETQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLKIEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGSGISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVGSALKYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLRVQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEGSLTEASLPEAQVASGAGAGAPRASSPEKAEEDRRLPGSQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGPQEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQALEQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQQHREQLLLEELVSLVNQRDELVRDLDHKERIALEEDERLERGLEQRRRKLSRQLSRRERCVLS
What is the function of this protein?
May act as Rab effector protein and play a role in vesicle trafficking.
What are the official names of this protein?
EH domain-binding protein 1-like protein 1.
What are the subcellular locations of this protein?
Endosome.
Protein: FADI_ECO81
Sequence: MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARTEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLRDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWSEGKLKEEVMTAFIPPYKQPLVEDNNIRGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMGDLTLIDMHEAFAAQTLANIQLLGSERFARDVLGRAHATGEVDESKFNVLGGSIAYGHPFAATGARMITQTLYELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHT1_CAEEL
Sequence: MHKAPISTLILDSLFSNMMLAEMMNDDQLELLKHQQTGIQPVVPEGCNLYWSSLNVTGPETKPTNFVDRFRNNMPKRRVKEILHNVSGMAESGKLLAILGSSGAGKTTLMNVLTSRNLTNLDVQGSILIDGRRANKWKIREMSAFVQQHDMFVGTMTAREHLQFMARLRMGDQYYSDHERQLRVEQVLTQMGLKKCADTVIGIPNQLKGLSCGEKKRLSFASEILTCPKILFCDEPTSGLDAFMAGHVVQALRSLADNGMTVIITIHQPSSHVYSLFNNVCLMACGRVIYLGPGDQAVPLFEKCGYPCPAYYNPADHLIRTLAVIDSDRATSMKTISKIRQGFLSTDLGQSVLAIGNANKLRAASFVTGSDTSEKTKTFFNQDYNASFWTQFLALFWRSWLTVIRDPNLLSVRLLQILITAFITGIVFFQTPVTPATIISINGIMFNHIRNMNFMLQFPNVPVITAELPIVLRENANGVYRTSAYFLAKNIAELPQYIILPILYNTIVYWMSGLYPNFWNYCFASLVTILITNVAISISYAVATIFANTDVAMTILPIFVVPIMAFGGFFITFDAIPSYFKWLSSLSYFKYGYEALAINEWDSIKVIPECFNSSMTAFALDSCPKNGHQVLESIDFSASHKIFDISILFGMFIGIRIIAYVALLIRSYNNT
What is the function of this protein?
Required for efficient RNA interference (RNAi) (PubMed:16723499, PubMed:18245353).  Plays a role in germline development (PubMed:16723499, PubMed:18245353).
What are the official names of this protein?
ABC transporter ATP-binding protein/permease wht-1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YIDD_XANC5
Sequence: MQVAYHWQVISRLLIALLRVYKLVISPLLGPRCRFAPSCSDYAMTAIGRFGPLRGSWLAARRLGRCHPFHPGGFDPVPDAPASPSPSSSCSCKGPHP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1436_DICDI
Sequence: MISSIYIFKILLSYLGVEYEINQLSEINQEFTNKLESYNQFIKHTQKDEDYLLGQSAVISRYISNNHNFSGKSLQESARVDDIVESVLEIIEEYVLPIINSNIINEEITKLLCTHFNDFENQLSKSTFSAGDSTTLADLYLFILYDITLRYLENHGHLAHHFNEKYPHLERLKLHFLSNKSVSEFINSNNINSQSSQLII
What are the official names of this protein?
Glutathione S-transferase domain-containing protein DDB_G0273153/DDB_G0273923.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: LSM6_ASPFU
Sequence: MENSSSSEGRDPSAFLGEIIGAPVTVKLNSGVVYKGELQSVDGYMNIALERSEEFVDGKLKRSYGDAFIRGNNVLYISAQ
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.