PharMolix/UniProtQA huggingface dataset:
Protein: DEF62_ARATH
Sequence: MDVTKTYVTIFVVAILTISVLIQIQQYDRCIGPCLRFYGNHQCYKNCRKAKYDGGQCDFVKKGEKLPECCCYYNKN
What are the official names of this protein?
Putative defensin-like protein 62.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_MEDSA
Sequence: MSPQTETKATVGFKAGVKDYRLTYYTPDYETKDTDILAAFRVSPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEETQFIAYVAYPLDLFEEGSVNYMFTSIVGNVFGFKALRALRLEDLRIPAAYVKTFQGPPQGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTVGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIFFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREATKWSPELAAACEVWKEIKFEFPAMDN
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: THIC_SALPA
Sequence: MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGHRVTQLHYARQGIVTPEMEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEVGMADMSESFRAKGGEIYLKREEA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: MIAA_ANASK
Sequence: MRLVVVAGPTASGKTALAIALARRLGGEIVNADSQQVYRGLDVGTAKPTAEERAAAPHHLLDLVEPGEGMDAARFAALADAAIAGIAARGRVPIVAGGTGLYVRALLHGVVEAPGRDPALRAALEEEAARLGRPAVHARLAAVDPAAAALIRPNDLVRVVRALEIAAGGRTPSELYRAHAFREDRYDAALLALDPPRAELHARIDARVRAMFAGGLLDEARALEARFDGALPARLPIGYAEAAAHLRGELDLEEAIRRVQVAHRRYARRQVIWLRKERGVAWIAPPHDVEALARRVLEPRPPAIR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: HSSS_STAS1
Sequence: MFKSLYTRIAIYTITVMIFSAVASFLCTNIIYHNYLKENNDAKIMRTLKDSIQYQKESRIEASAPFFKHLGEMNYQVMTISEDGHRTYYGTEFRKDNISKKTAESVLHGKDYHGIKNLPYNPIITGFFENTTKNTVGIAYQSKGHTYAVFMRPDIGKTFSEFRIFLAILITLLLLFSIILVISSTYAIIKPIQQLKRATERLMHGNFDEVIHVTRKDEFGTLQYRFDKMRLSLKQLDDMRQHFVQNVSHEIKTPLTHIHHLLDLLKFAKTDNAREQYIEEIYEVTTQLSELTKALLLLSEIDNGAHLDFDDDIQLNQLIKKIIRHEQFSANEKDLIIMSDLETISMNGNERLLHQAFQNLITNAIKYSTTGGMVDVTLSQNLETITCTITDDGQGMSAETQARIFERFYKSSNHDNSNGLGLAIAKAIFELHHGTITVDSEKNAGTTFTITFKKVPKTIS
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR.  HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
What are the official names of this protein?
Heme sensor protein HssS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UCHL1_PIG
Sequence: MQLKPMEINPEMLNKVLTRLGVAGHWRFADVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
What is the function of this protein?
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.  This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).  Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).  The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Ubiquitin thioesterase L1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor.
Protein: EFG_MYCMS
Sequence: MAREYSLLNTRNIGIMAHIDAGKTTTTERILFHTGKIHKIGETHEGASQMDWMAQEQERGITITSAATTAFWKNTRFNIIDTPGHVDFTVEVERSLRVLDGAVAVLDGQSGVEPQTETVWRQATNYKVPRIVFVNKMDKTGADFIYSVKTIGDRLGAKAAPIQLPIGAEENFTGIIDLVEMKAYEFDGKPEENYKEIEIPTNLLEQAKELRAHLVEVAVEYDEELLMKFLDGGEISISELKSAIRKGVINADFFPVLAGSAFKNKGVKLLLDAVVDYLPSPLDIPSIKGILPTGEEVERHADDTEPFSALAFKVMTDPFVGKLTFFRVYSGILTKGSYVLNSTKQQKERVGRILQMHANNRTEIEEVYSGDIATAVGLKNTTTGDTLCDEKGEIILESMVFPEPVIQLALEPKTKADQEKMSIALSKLAEEDPTFRTYTDDETGQTIIAGMGELHLDIIVDRMKREFNVATNVGAPQVSYRETIKLPGKAEGKYIKQSGGRGSYGHVVIEFEPNKDKGFEWVDKITGGRVSKEYINSARVGLENALRNGVIAGYPMIDVKATIVDGSMHEVDSNEMAYKIAASMALKEASKKMNPVVLEPIMNVEVTVPDEYYGDVMGNISSKRGIIEGSEQRGNAQTIKSKVPLTEMFGYATELRSFTQGRGNYTMIFSHYAEAPKAIADEIIKKSGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_BORBU
Sequence: MKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLEFLGDSVLNLIITDHLYKTYPNKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFDMYIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKAMENINL
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM25_HUMAN
Sequence: MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK
What is the function of this protein?
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.  Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression.  Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression.  When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L.  Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence.  Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner.  Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.  Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
What are the official names of this protein?
RNA-binding protein 25, Arg/Glu/Asp-rich protein of 120 kDa, RED120, Protein S164, RNA-binding motif protein 25, RNA-binding region-containing protein 7.
Protein: SIGG_MYCTU
Sequence: MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAENSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein.  May be involved in host intracellular survival after infection (strains H37Rv and CDC 1551).  A role in the SOS response is controversial; it has been seen in strain CDC 1551 (PubMed:18039768) but not in H37Rv (PubMed:21169493).
What are the official names of this protein?
ECF RNA polymerase sigma factor SigG, ECF sigma factor SigG, Alternative RNA polymerase sigma factor SigG, RNA polymerase sigma-G factor, Sigma-g factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: CE046_BOVIN
Sequence: MAVSGLRLTIVWGLLVLILTCQADDKPEGKPDEQPHDSGKNSEPAFPKFLNILGSDIIENAVEFILRSMTRSTEFLEHGDKQGEHSSK
What are the official names of this protein?
Uncharacterized protein C5orf46 homolog.
What are the subcellular locations of this protein?
Secreted.
Protein: THIM_RHILW
Sequence: MQSRTTPGAMLTAMREKPPLVQCITNYVAMNIAANVLLAAGASPAMVHAAEEADEFAGIASALTVNIGTLSTQWIDGMQAAAKATTAAGKPWVLDPVAHYATAFRRDAVAGLLALKPTIIRGNASEIIALAGGESRGQGVDSRDPVEQAEGSARWLAERQQAIVAVTGAVDFVTDGERAVRITGGSALMPQVTALGCSLTCLVGAFAATAPEDLFGATVAALATFAIAGEEAALGAAGPGSFAWRFLDALHALDAETLDARARISAA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RR3_LOLPR
Sequence: MGQKINPLGFRLGTTQKHHSFWFAQPKNYSEGLQEDKKIRDCIKNYIQKNRKKSSNRKLESDSSSEVITHNRKNDSGSSSEVITRIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEIHSVNQRLNISIEKVKEPYREPNILAEYIAFQLKNRVSFRKAMKKAMELTKKADIKGVKVKIAGRLGGKEIARAECIKKGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RR4_LYGSP
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSRSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVQIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQNSIASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SP130_HUMAN
Sequence: MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV
What is the function of this protein?
Acts as a transcriptional repressor.  May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
What are the official names of this protein?
Histone deacetylase complex subunit SAP130, 130 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p130.
What is the protein family that this protein belongs to?
Belongs to the SAP130 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGJ_ARCFU
Sequence: MEITDIGGVLCNGIKEGKYGLGLVRVRGSIAGVFTQNKIRAAPVIVCEENIRDGVVEGVIVNSGNANAYTGEQGMRDAREMCRIAANLLGCEERRVAVASTGVIGRKLDMEWIRKKAPEVYSGLGNSVENAERFGRAIVTTDRFVKKAYSEKARIAAVAKGAGMIAPNMATMLCFAFTSAKFDSGELYDMLRRAADKTFNRLTVDGDTSTNDTVLLISTGKERVERDVFEEELCSVFYSIAKQMARDGEGATKVFEVRVDGARNDEDANLIARAVASSLLVKTAIFGCDPNWGRIIAAAGYSGADVDERITLSLSDGRDEVFLIDSGRPLGNEERARVLMEKAEELVIRLRLEKGNGKGFAIGCDLTYDYVKLNAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATA_THEPX
Sequence: MSQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGPGDPVVSTGEPLSVELGPGMLEGIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFTPKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVEDIREGEYTVTEPIARIKTDSGQIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTVVQHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLARRLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEPVTQATLRVVKVFWALDSELAYARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGIDVLSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGVPFSEIEKHPVREKIARAKYVEESKLTVFDEIEKEIKKAMQGLIEGGAADA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: PELI_DROME
Sequence: MVKRTDGTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQDNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQVNQPYVYLNCGHVQGHHDWGQDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD
What is the function of this protein?
Scaffold protein involved in the Toll signaling pathway via its interaction with pelle/pll kinase.
What are the official names of this protein?
Protein pellino.
What is the protein family that this protein belongs to?
Belongs to the pellino family.
Protein: THIE_DESHD
Sequence: MAVDYSLYLVTDRILVGPKDFLLSIRKALEGGVTLLQLREKETNSREFYDIGVKVKELAAEFGVPLIINDRVDLALALDADGVHVGQQDLPLAKVRNIIGPDKILGYSVSSLEEALQGERMGADYLGAGPVFPTGSKKDAAEAIGLAKLKEIKAGVSLPVVGIGGIGAANLRVVKETGIDGVSVISAILSQEDPCAAAKGLVDLWRN
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: TRM5_BATDJ
Sequence: MKYIFAPPANKGLQQLNHALFESSHTLPALKIPAHASGIAMETLRSHILVAPRLRTIVDDPTDKKWRLLLLDPSMEASEINDLPNPLKEFALKHEAKLVKHTIELKYDYWTSDQVLRSILPDEMETPGAFETVGHIAHLNLRDRYQPFKHIIGQVILDKSSHIKTVVNKLDNIDHTFRFFQMEILAGINDMNAKLKEGGCFFHFDFSKVYWNSRLQGEHDRIIKLFGQNDLICDVFAGVGPFALPAAKHKRCVVFANDLNPQSFKYLMENIKLNKLETRILPFNMDGRQFIKQSLEDLNNPAIWNKITKQKPTSNDKKRNRKVESPTVAPLTDQPAISGIRHFKHYVMNLPATAIEFLDAFHGLYSGMRDVIMDSDLPTIHCHCFSNAKDVKADVIERVERVIGMPLGSNLIMVHSVRTVAPNKDMLCISFRLPSALAFAEPKILGKRKGLETEENLVSQSDVSKSSDNILEKDT
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: MTNC_CROS8
Sequence: MIRAIVTDIEGTTTDIRFVHNVLFPYARERLERFIRSGEQREPVNLLLNELRGEIHAPAASVDQLIETLFKFMDEDRKSPALKSIQGYIWREGYVNGDFTGHLYPDVVPALRRWSAQDIDIYIYSSGSVPAQKLLFSHSDEGDVTELLSGFFDTHVGAKRQVSSYRNISMKTGVPVHQMLFLSDIREELDAAREAGWKTVQLIRGEPDTQSTHRQVSSFDDIHPEQIPT
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: SRBS2_MOUSE
Sequence: MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEVPSPVPPPHVPPRPRDQSSTLKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSIYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGDDSKMCPPLCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKILTPQKQTEKAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSPMHQPFHPLPPDGASHCPLYQNDCGRMPHSASFPDVDTTSNYHAQDYGSALSLQDHESPRSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLPHSYSSDRIYTLSSNKPQRPGFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
What is the function of this protein?
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton.  Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity).  May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity).
What are the official names of this protein?
Sorbin and SH3 domain-containing protein 2, Arg-binding protein 2, ArgBP2, Arg/Abl-interacting protein 2.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, myofibril, sarcomere, Z line. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells.
Protein: RISB_GEOKA
Sequence: MRIIEGNLVGTGLKIGIVVSRFNEFITGKLLSGAIDGLTRHGVSDSDITVAWVPGAFEIPLVAKKMAESKQFDAVITLGAVIRGATSHFDYVCSEAAKGVSHAALASGVPVIFGVLTTDTIEQAIERAGTKAGNKGWEAAVSAIEMANVLRTLA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.