PharMolix/UniProtQA huggingface dataset:
Protein: FLNA_DROME
Sequence: MEAERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRMPKYNKRPTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNRVRAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSDARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYYPTKEGRYVIMVTFAGQEVAKSPFEVKVGPKKESSIVAYGPGLSSGVIGYPAAFVVETNGETGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRTDFHPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREAGDAELKVKIIHEETKIEVPCRIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRVPLGEKVVVEQTVDVSKIKVDGLEPSVIMNAATDFMVDMSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVLVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQAPKIQTSGSQSHLKVDAREAGDGAVTCKITNKAGSEIVDIDVIEKDGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVESIEQYSHSEYIEEHTTKVVQQTTQSELVNGKSEITYRSVAFEKLPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGDITDDDLRALNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTLNISYKPTEPGYYIVNLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPGITSFDLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGKDVADPAAVHASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYITVKYNNMHIVGSPFKVNATGDKLADEGAQETSTVIVETVQKVAKGGKNTGVHLPTFKSDASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVRDRGQYVLLIKWGEEHIPGSPFQIDV
What is the function of this protein?
Involved in the germline ring canal formation.  May tether actin microfilament within the ovarian ring canal to the cell membrane.  Contributes to actin microfilaments organization.
What are the official names of this protein?
Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Filamin-1, Filamin1.
What is the protein family that this protein belongs to?
Belongs to the filamin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane. Note=Localizes to intercellular bridges corresponding to ring canals that connect cytoplasm of nurse cells to the developing oocyte. Localizes to nurse cell plasma membranes. Detected in both the inner and outer rims of the ring canal.
Protein: YIDD_FUSNN
Sequence: MKKILILLIRFYQKFISPMFPAKCRFYPTCSQYTLEAIKEHGTIKGTYLAIRRILKCHPFHEGGYDPVPKRKNKNSEGKREE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HEM3_CHLMU
Sequence: MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDDIDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDILVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHFFS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RISB_ACIBC
Sequence: MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVNEDNITVIHAPGAWELPIVAKKLATSNQFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GM4D_PSEAE
Sequence: MTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGDIQYEDGDMADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSPETRFYQASTSEMFGLIQAERQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHASSGILFNHESPLRGIEFVTRKVTDAVARIKLGKQQELRLGNVDAKRDWGFAGDYVEAMWLMLQQDKADDYVVATGVTTTVRDMCQIAFEHVGLDYRDFLKIDPAFFRPAEVDVLLGNPAKAQRVLGWKPRTSLDELIRMMVEADLRRVSRE
What is the function of this protein?
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
What are the official names of this protein?
GDP-mannose 4,6-dehydratase, GDP-D-mannose dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
Protein: NSP6_ROTPY
Sequence: MNRLLQRQLFLENLLVGVNSTFHQMQKHSINTCCRSLQRILDHLILLQTIHSPVFRLDRMQLRQMQTLACLWIHRRNHDLQVTLGAIKWISP
What are the official names of this protein?
Non-structural protein 6, NSP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus A NSP6 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: KDPC_BURMS
Sequence: MKSLFRPLIVVFVVLVAVTGLAYPAVMTVFGQAVFPAQANGSLIEKGGRVVGSALIGQQFDAPQYFWGRLSATSPMPYNAAGSGGSNLGPLNPALKDQVKSRLDALKAAGTDLSQPVPVDLVTASASGLDPEISPAAADYQVARVARARKMADADVRRLVADHTSGRQFGVLGEPRVNVLKLNLALDAAQAAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: QUEA_ALKEH
Sequence: MHVDDFSFDLPEALIAHHPPEQRRDSRLLCLDRDTGAVADRRFPDLVDLLRPEDLLVLNDTRVIPARLFGHKPTGGRVEVLVERPLDRHRVLARLRASKVPAPGTVLTLEGGVAAEVTGREGEFFTLRFTAEQTVLELLEHHGHMPLPPYIRRADVAADRERYQTVFARRPGAVAAPTAGLHFDNELLARIGARGVDTAWVTLHVGSGTFAPLRVSDPREHRMHSEWLDVPPATCAAIERARGRGGRVVAVGTTVVRALETAAQDGAVQPYQGETDIFIYPGHRFHAVDALVTNFHLPGSTLLMLVSAFAGRERVLAAYRHAVAQRYRFFSYGDAMFIAAGAADE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_CERS1
Sequence: MKAEVIKLDASPAGSIELDDAIFGLEPRADILHRVVRWQRAKAQAGTHSVLGKSDVSYSTKKIYRQKGTGGARHGSKKAPIFRHGGVYKGPTPRSHAHDLNKKFRALGLKHALSSKATTGNLIVLEDIALAEGKTAMLAKAVKELGWKRVLVIDGADINENFAKAARNLEGVDVLPSIGANVYDILKRDTLVITKAGVEALEARLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: AROC_METS4
Sequence: MSHNSFGHLFRVTTFGESHGPALGCVVDGCPPLIPLDAAEIQAELDRRRPGQSRFTTQRREPDAVRILSGVFADDRTGGRQLTTGTPIALMIENVDQRSKDYSDIRDTYRPGHADYTYEAKYGIRDYRGGGRSSARETAARVAAGAIARKVLPGVTIRGALVQMGPHAIDRARFDWAEVGNNPFFCPDAEAAARWAEVLDGVRKDGSSLGAVIEVVAEGVPPGLGAPVYGKLDADLAAAMMSINAVKGVEIGDGFAAAALRGEENADEMRPGHGGAPSFLANHAGGILGGISTGQAVVCRFAVKPTSSILTPRASVTRDNRPTDVLTRGRHDPCVGIRAVPVGEAMMACVLADHVLRHRGQVGAHPAGAHPAGADPAGTHPGGPGGFQPG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: TRPD_AZOBR
Sequence: MSTPSAPHGDLTDMKAILAKVAAGNALNEAEASLAFDIIMSGNATPSQMGGFLMALRVRGETVDEITGAARVMRAKAIPVEAPDGTIDTCGTGGDGSGTYNISTAAAVVIAACGVPVAKHGNRAMSSKSGAADVLGALGVNLDCDLGLVRKALWDARIGFLMAPRHHLAMRNVGPTRVGTRTIFNLLGPLSNPASAKRQLLGVYAKQWVEPLAHVLKRLGSEAAWIVHGSDGLDEITTTGPTTVAQLKDGEVTVFEIEPEQAGIFRARPELLKGGDAHVNAEAIRALFDGAQGAYRDIVLLNAAAALHVAGKAGDLKEGDERARHAIDSGAARAVLQHLVSITNSSITNEPVAAP
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TTCA_CELJU
Sequence: MTSLNQRKDRLEFNKLQKRLRRQTGSAIVDYNMIEDGDKVMVCLSGGKDSYTMLDILLSLQQTAPIRFELVAVNMDQKQPGFPEHVLPNYLAQLGVPFHIIERDTYSIVKEVVPEGKTTCGLCSRLRRGTLYGFADEIGATKIALGHHRDDIIETLFLNMFYGGKLKAMPPKLLSDDKRNIVIRPLAYCAEEDIAEFARLKGFPIIPCNLCGSQENLQRQAVKEMLHAWERQFPGRTETIFTAIRNVQPSQLGDLELFDFVNLAIDKTATAVEDASDACAVPNWHRPAQEEVVQYVDVLDIH
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRS1_HCMVM
Sequence: MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGATSTAGTGASAAPTATPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTVGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTTSPPAASGTETEAAGGDAPCAMAGAVGSAVTIPPQPYGGAGGSAICVPNADAHAVVGADATAAAAAAAAAPTVMVGPTAMAGPAASGTVPRAMLVVVLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQLAFLLRPGRGEAEVLTLATKHPVICANVEDYLQDARRRADAQALGLDLATVVMEAGGQMIHKKTKKPKGKEDESVMKGKHSRYTRPTEPPLTPQASLGRALRRDDEDWKPSRVPGEDSWYDLDETFWVLGSNRKNDVYQRRWKKTVLRCGLEIDRPMPTVPKGCRPQTFTHEGIQLMGGATQEPLDTGLYAPSHVTSAFVPSVYMPPTVPYPDPAARLCRDMRRVTFSNVATHYHYNA
What is the function of this protein?
Inhibits the establishment of the antiviral state in the infected cell.  Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha/EIF2S1 and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR.  Also inhibits host autophagy by interacting with host Beclin-1/BECN1 (By similarity).
What are the official names of this protein?
Protein TRS1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US22 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus.
Protein: CCD47_XENLA
Sequence: MILFTRLLAVSLLLVSGAFAKFQEFDDSDDVAEYDDNDFAEFEDAADEAPTLRPPSQQVPEKEDEIEDDDEEEEEATVELEGQEEFEEDTEGQEGDADAEPYDDEEFENYDDRLDTGTPNKNNDPITIVDVPAHLQNSWESYYMEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFSLVGDDGMNKDAVSTGMLNQENDHIYNMWCSGRLCCEGMLIQLKFIKRQDLLNVLSRMMRPVCDQVQIKVTMNDEDMDTYVFSVGTRKTLIRLQKEMQDLSEFCGDKPKSAAKMGLPESMAVLAEMGEVTDGIMDTKMVHYLTNYSDKIESIHFSDQFSGPKIMQEEGQPLKLPETKKTLLFTFNVPGSGNASVKDMEALLPLMNMVIYSIDKVKKFRLNREGKQKADKNRARVEENFLKITHVQRQEAAQTRREEKKRAEKERIMNEEDPEKQRRLEEAAQRREQKKIEKKQMKMKQIKVKAM
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
What are the official names of this protein?
PAT complex subunit CCDC47, Coiled-coil domain-containing protein 47.
What is the protein family that this protein belongs to?
Belongs to the CCDC47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane.
Protein: VATA_DEIRA
Sequence: MTQQKQGVVQSIAGPAVIAKGMYGAKMYDIVRVGQERLVGEIIRLDGDTAFVQVYEDTAGLTVGEPVETTGLPLSVELGPGMLNGIYDGIQRPLDKIREASGNFIARGIEVSSLNREQKWDFTPSVQAGDTVTGSGILGTVPEFSFTHKILVPPEVQGRLRSVAPAGQYTIDDTIAELEDGTKLRLAHYWPVRAPRPVQKKLDPSLPFLTGMRILDVMFPLVMGGAAAIPGPFGSGKTVTQQSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVAAREASVYTGVTLAEYFRDQGYSVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAKLAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQATLRITGAFWRLDAGLARRRHFPAINWNGSYSLFTPILDKWYRENVGPDFPELRQRIGSLLQQEAALQEVVQLVGPDALQDNERLIIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMFLKFYDEAEAALRNGLTIDEIIQNPVIEKLARARYTPENEFMAYGEGVMDELDQTFKAVKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit (By similarity).
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: NU1M_SALSA
Sequence: MTTTLITHIINPLAYIVPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADGLKLFIKEPVRPSTSSPFLFLATPMLALTLALTLWAPMPIPYPITDLNLGVLFVLALSSLAVYSILGSGWASNSKYALIGALRAVAQTISYEVSLGLILLSVIIFTGGFTLQTFNVAQESIWLLVPAWPLAAMWYISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYANILLMNTLSAILFLGASHIPAFPELTAVNLMTKAALLSVVFLWVRASYPRFRYDQLMHLVWKSFLPLTLALVLWHLALPTAMAGLPPQL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AQP1_HUMAN
Sequence: MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TILS_SALPA
Sequence: MTTLTLNTSLLSSCRILAAFSGGLDSTVLLHQLVLWRERHPDVTLRAIHIHHGLSPHADSWVRHCETVCERWQVPLVVERMTLADNGLGIEAHAREARYRAFAQTLLPGEVLATAQHLDDQCETFLLALKRGSGPAGLSAMGERSPFAGTLLLRPLLRETRKTLEQWAVRHGLCWIEDESNQDDAYDRNFLRLRALPLLQRRWPHFPAAVARSATLCAEQERLLDELLASDLTDCITAEGTLRLSPLMLMSDVRRAAILRRWLAMRNAPMPSRDALERIWQEVALARDDASPCLRFGDHEIRRYQSQLWWIKSVAGQHETTVVWPVWQTPLALPAGLGTVQLVPGGELRRPREEESVSIRFKAPGVLHIVGRNGGRKLKKIWQEQGIPPWRRDTTPLLFYGETLIAAAGVFVTREGAAEDKEGVSLVWHA
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_CERS4
Sequence: MSTIIDIHAREILDSRGNPTVEVDVTLESGAFGRAAVPSGASTGAHEAVEKRDGDKSRYMGKGVLEAVAAVNGEIAEMLVGFDATEQVGIDRTMIEMDGTPNKGRLGANAILGVSLAVAKAAAEFTNQPLFRYVGGSSARVLPVPMMNIINGGEHADNPIDIQEFMIMPVAAQNVREAIRMGSEVFHTLKKELAAGGFNTGIGDEGGFAPNISSTREALDYILRSIEKAGYKPGEDIYLALDCASTEYFKGGKYEMKGEGKSLTSAENVDYLAALCADYPIISIEDGCAEDDWEGWKLLTDKLGAKVQLVGDDLFVTNPKRLEQGIKAGVANSMLVKVNQIGSLTETLMAVDMAHRARYTNVMSHRSGETEDATIADLAVATNCGQIKTGSLSRSDRLAKYNQLIRIEEMLGEVAEYAGRSILKV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CAP8_ADEG1
Sequence: MNLMNATPTEYVWKYNPVSGIPAGAQQNYGATIDWVLPGGTGFAIATNDIRRQTLNPAVTRAITARFEAESDQQPYASPHETNVIAANVLDSGYPKSGLYPLELSGNQRVQLAGGLMVGRTEGRMQLAGGLTEGRVQLSGGFHGRPLVRGRSRRPPRWCGAELTGNGLPEQAEVTSDTYKYFLRTQGPSQVVEEPGVFSQRQFMTTFLPSVVPHPFDSTNPGDFPAQYSAIYKGRTAFEDTFWDW
What is the function of this protein?
Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
What are the official names of this protein?
Pre-hexon-linking protein VIII, Pre-protein VIII, pVIII.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon-linking protein family.
What are the subcellular locations of this protein?
[Hexon-linking protein-C]: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion. SUBCELLULAR LOCATION: [Pre-hexon-linking protein VIII]: Host nucleus. SUBCELLULAR LOCATION: [Hexon-linking protein-N]: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion.
Protein: RL20_SHEWM
Sequence: MPRVKRGVTARARHKKVLKLAKGYYGARSRTYRVAVQAVTKAGQYAYRDRRQKKRQFRQLWIARINAASRQNGLSYSRFINGLKKASIEIDRKILADIAVFDKVVFTTLVEKAKEALAK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ETS7_CAEEL
Sequence: MSSKRTSPNGKQRLLNFLRGLLEDDSHSDLITWSNKDTLEFQMLKPHKVAELWGAATGNPGMNYDKMSRGLRYFYTNNTLKKVKGKDSRYCFLDTPLLAPFPDFFPKANEPMRRVPLFSIENLLASSEETTSNFSLQSSPSSSSNSSSARTMSATSSPTSSLEDVINPPVLIDPFQMQMAHITQTFLATQLPALQAFPMQLQLQFLKTLLPTLFPNNN
What is the function of this protein?
Probable transcription factor (By similarity).  Involved in responses to oxidative stress (PubMed:27514077).
What are the official names of this protein?
ETS domain-containing protein ets-7, ETS class transcription factor ets-7.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EIS_MYCTU
Sequence: MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
What is the function of this protein?
Can also acetylate multiple amine groups of many aminoglycoside (AG) antibiotics, leading to their inactivation, and thus contributes to drug resistance (PubMed:19906990, PubMed:21628583, PubMed:24106131).  Is also able to acetylate and deactivate the cyclic peptide antibiotic capreomycin, but not the other anti-tuberculous drugs isoniazid and pyrazinamide (PubMed:23233486).  Acetylates kanamycin (KAN) more efficiently than amikacin (AMK), even though Eis seems to bind AMK with higher affinity (PubMed:19906990).  Does not acetylate and inactivate streptomycin, apramycin and spectinomycin (PubMed:19906990, PubMed:21628583).
What are the official names of this protein?
N-acetyltransferase Eis, Aminoglycoside N-acetyltransferase, Enhanced intracellular survival protein, Protein-lysine N-acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase Eis family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, bacterial extracellular vesicle. Host extracellular space. Note=Eis is present in the macrophage cytoplasm from 4 to 96 hours post-infection.
Protein: GALT_CALS4
Sequence: MTQKDAAFHIERLLKFALKKGLIEELDVIPSRNALMDLFKIEKPYEGEVPEEELDTPSPILNKLLDYGVEIGLIEDTVTYRDLMDARIMGLLMPRESEVVRKFNEIASKDGIEKATEYFYELSKASNYIRMDRTSQNLYWRTPTEYGALEITINLSKPEKDPKEIEKAKKIPQSGYPKCLLCIENVGFAGNLNHPARQNLRIIPVKVAGEQWYFQYSPYVYYNEHCILLHEEHIPMKISEKTFVRLFDFIDQFPHYFMGSNADLPIVGGSILVHEHFQGGRHTFPMEEAPIEEYFIHPKYKEVKAGILKWPMSVIRLSSKDREKLTKLSSHILNVWKGYSDESVDVLAYSEKDGKIVPHNTITPIARFNKEGEYEIDLVLRNNRTTDKYPYGIFHPHEELHHIKKENIGLIEVMGLAVLPGRLKFELEEIRKILTGKEKFNKDMYDENHPLYKHLHWIEELIVKYGTHCTEEEAENYIKQEVGNKFLQVLLDAGVFKRDEKGKKAFEKFMETAGFKKLS
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.