PharMolix/UniProtQA huggingface dataset:
Protein: TF2H3_MOUSE
Sequence: MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVLANSHLFMNRSNQLAVIASHIQESRLLYPGKNGGLGDFFGDPGNALPDCNPSGSKDGKYELLTVANEVIAEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRVNKAVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAACFCHRSLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKQKVSL
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription factor IIH subunit 3, Basic transcription factor 2 34 kDa subunit, BTF2 p34, General transcription factor IIH polypeptide 3, TFIIH basal transcription factor complex p34 subunit.
What is the protein family that this protein belongs to?
Belongs to the TFB4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIMP3_MACMU
Sequence: MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
What is the function of this protein?
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.  May form part of a tissue-specific acute response to remodeling stimuli.  Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).
What are the official names of this protein?
Metalloproteinase inhibitor 3, Tissue inhibitor of metalloproteinases 3, TIMP-3.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RPOA_SALPA
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: E2AKB_CAEEL
Sequence: MTKENQIVLDERVKENQHLQEEEKLALDAVYLNQITYIKAHWHVWVPTNCHILLKALDSCFLNGDPLGKSKLSVILHVKCSEDYPQRKPAVDLLDPQGLSKEDVQNLLTILRQMADTWEGCVVIAELAHRVREFLTDHTPRPAGSFHDDMLANKVRTEAEKQRKRLDTEQKELELLEEEMRQRNAIEMEKTLNGTRQENETRIIGGRRIVVLSNMPNTQLLISEWTFRFSSNRNPAEGKRKDFAPFLQKLDAVYNEIQKLCEIKGLDQNLVEYAFVHLQKISVSPDQILIQLNVAQKIFSSEENMQDTYELIVQKSNLLRLLAAQAICGLRYLHEASMTHKHLTLGSVWTRNSTGDCVFRFSDFGSMGPLLDLVKMFGDICSGKYVARDEDKEKEYDRRRKDLFQLGTLLDGLILATRGSTYSRVPTPVEGNQNTGTNLLGNFIAKCQEAKNIDQLVEDPFLKEECQSESENIFTPFGGAMSPDGRMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAEDLIPIVEETSDDDSSLGAVPIPGKEKIGKKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDSSEIDWDAESEEVEDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTTTTSKSKLAIDVVPVRKPRILCIQMEYCDRATLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLRDDIKIPSDFGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDLPMHTKEDATFRNLCEKVIKKRDGRMNAWLLDKQFKEEVPTSLNYCYDVDICLERAKYNNREVLVETLRAEFCKILKIHSFEKLHTHTLMPVSTALAAASVRTKPVEVLDRSGVPVALPMDLRQNFVRFCVRNSVQRMKRFNFGRVYSQTSANGHPHERWECCVDCIGPQCSSPSLEAELLLVACEMMIGSLPGMKFTLKIGHAQLIEAQIRHLKLSDDVRAELLDALHLISVSDRPHSHKEKMDMLTPKIGAKAANIITKLLIPVEDNFGAFKEKVACFRKKLKVDAARVLVDKAIRDLEEIVGTFKFCRTEAIEQISIVYDSQTCYRPRTFGDGLLFQIQVEKPSTIANNKRGRRQNVLAGGRYDSALLRERHPRDFVYEIPLCISGFGVAMDVVSQIRDSINKSANIPKTPQNHCKVLICSMVQPDGSNLITQKFELAKKLWSMGIEADVFHIPVDDLESLTEHRNRASITHILAVYNTLNEVICKTETSSETMDVDSAISSVWRGVQALDGQSIHMTPCGGGPISSISTPGEAHHHDDHHPGTPVIASKCFRSSVSTTVATTSIRPISATVANLNVILVTSADRFHKVMKEKKRVESQVRNHLTEFVAHFTSKTRIEVLVCDIPADVIKKIVSELTKTSSEAEIDKLFDQLIQKHGKVDLSPLRRQFHITLNGISTGSAQVAILFYRQSDNFYRYLV
What is the function of this protein?
Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity).  Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha (PubMed:20733002, PubMed:23076791, PubMed:22719267, PubMed:23692540).  In addition, leads to the selective translation/transcription of some mRNA including atf-5, pha-4 and gpdh-1 which are part of the UPR (PubMed:23076791, PubMed:23692540).  Required for maintaining lifespan during amino acid starvation (PubMed:23692540).  Involved in hypoxia-mediated adaptive protective response (PubMed:20733002).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase gcn-2, General control nonderepressible kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: MIAA_ACIB3
Sequence: MSNQLPVINLMGPTASGKTALACELYERGNFELISVDSALVYKDMDIGTAKPTREEQELYPHHLIDIITPLEVYSAAQFVEDACALIDEMHSRGKTPILVGGTMLYFKALLEGLSSNLPSADANVRAAIEEKAANEGWQAVYDELVAVDPAAGVKFKVSDKQRIIRALEVYRITGQPITKLQAEQPKNVPYRYTFHNYALLPDRLELHQRIEQRLSKMWDIGFLSEVESLIEKYDLDENLPSMRSVGYRQALEFLLKSDMSLKKKQEMEDKALFATRQLAKRQYTWLRSLQEIHDFKTYLTIKQAKEDLRNSYG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ADD_MYCLB
Sequence: MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASHSGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIDVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVLVG
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: ISCU_HAEIN
Sequence: MAYSEKVIDHYENPRNVGSLDKKDSNVGTGMVGAPACGDVMQLQIKVDDNGIIEDAKFKTYGCGSAIASSSLITEWVKGKSLEEAGAIKNSQIAEELELPPVKVHCSILAEDAIKAAIADYKAKQG
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Subsequently gives the nascent cluster to other proteins.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU, Sulfur acceptor protein IscU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: YAG5_STAAU
Sequence: MKVQIYQLPIVFGDSSKNETQITQWFEKNMNAEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGEYVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
What are the official names of this protein?
Hydrolase in agr operon, ORF 5.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Protein: DEFB1_TRACR
Sequence: MRTSYLLLFTLCLLMSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK
What is the function of this protein?
Has bactericidal activity.  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Protein: 1433T_MOUSE
Sequence: MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.  Negatively regulates the kinase activity of PDPK1 (By similarity).
What are the official names of this protein?
14-3-3 protein theta, 14-3-3 protein tau.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y880_STAAR
Sequence: MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYIEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
What are the official names of this protein?
UPF0051 protein SAR0880.
What is the protein family that this protein belongs to?
Belongs to the UPF0051 (ycf24) family.
Protein: SYK_THEKO
Sequence: MVHWADYMAEKIIRERGDKEEYVVESGITPSGYVHIGNFREFFTAYIVGHALRDRGKRVRHIHMWDDYDRFRKVPKNVPPEWKEHLTKPVREVPDPWGCHESYADHFMSLFEEEISKLGIEADFLHASELYKSGEYAKEIRLALEKRDEIKAILDKYRERAKQPPLEDSWQPVMIYCPHCRKEAEFVSWDGEWKVSYKCPHCGAEGETDIREGNVKLRWRVDWPMRWAHFKVDFEPAGKDHLAAGSSYDTGKEIVEKVFGWKAPLTLMYEFVGIKGQKGKMSGSKGNVILLSDLYEVLEPGIIRFIYAKARPNKELRIDLGLGLLNLYDEFDRVERIYFGLEHAKNPEEEEELKRTYELSMPKLPERLVAQAPFRFLVTLVQMPHLDEDGIIRILQEQGHVPENLTDDDIERIKLRIRLAKNWVEKYAPDDVKFSLLERPPEIELRPEIREAMLEVAEWLEEHERFSVDELNNVIFDAAKKRGIPSKEWFKALYNIFIGKDRGPRLAPFLASLNREFVIKRLRLEG
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM8_YEAST
Sequence: MQTPSENTNAKSDSLDEPGAYLIEENVALPKDIFHSYLSYWIYEAAHCTPVMLLSLVIGVLISIIILFHDNENCVGVSVGFLLIFSGILVIVLILRFGPQISDEDFKCKLLMEIITRKPTVKGKEWRTITYKMNQYLFDNDLWNTPYYFYRDEDCHRYFLSLIKGRTFKKQKESSASNVKDAQSNDETAGTPNEAAESSSFSAGPNFIKLLTKAAEIEQQFQKEYWRQEYPGVDEFF
What is the function of this protein?
May be involved in endoplasmic reticulum exit trafficking of proteins.
What are the official names of this protein?
Pheromone-regulated membrane protein 8, DUP240 protein PRM8, Protein DUP1.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
Protein: VSP3_CROAT
Sequence: VIGGDECNINEHRSL
What is the function of this protein?
Snake venom serine protease that cleaves fibrinogen Aalpha chain (FGA), partially cleaves Bbeta chain (FGB) and has no activity on gamma chain.  Is less potent than A1 and A2 alpha-fibrinogenases.
What are the official names of this protein?
Alpha-fibrinogenase A3, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TAN1_YEAST
Sequence: MGEKRNRNGKDANSQNRKKFKVSSGFLDPGTSGIYATCSRRHERQAAQELQLLFEEKFQELYGDIKEGEDESENDEKKDLSIEDQIKKELQELKGEETGKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPITYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFNTIERMDIINQVVKLVNKEGSEFNHTVDLKNYDKLILVECFKSNIGMCVVDGDYKTKYRKYNVQQLYESKFRKDEDKSVKQ
What is the function of this protein?
Probable tRNA acetyltransferase required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs.  Binds RNA.
What are the official names of this protein?
tRNA acetyltransferase TAN1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: E1BS_ADEC2
Sequence: MDPLKLENYLTFRAIIRGSTLSPGFFRRWCFPALADVVGNIVVQEEGRFWQILPENHAFWGLLRRGFTVASFTEIITAAQLENERLSRQLAFLAFISFLLRNWPSDSLVPEADRLDLVCAPAWSRMQIWTQTARLINDLQDSVLEEQGSAEEEECEEALLAGDSDDPLFG
What are the official names of this protein?
E1B protein, small T-antigen, E1B 19 kDa protein, E1B-19K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 19 kDa protein family.
Protein: GLPE_YERPB
Sequence: MEQFEAISVEQAYLRWKEGKTALVDIRDPQSYEAGHAPGAFHLTNSSLHTFMQQTDFDQPVMVMCYHGNSSKGAAQYLLQQGFDVVYSIDGGFEAWARSYPQDITSESR
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_OCHTH
Sequence: MTNIRKSHPLMKIVNHSLIDLPAPSNISAWWNFGSLLGLCLGIQIVTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFLHVGRGIYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFILPFIIAALVMVHLLFLHETGSNNPTGIISDADKIPFHPYYTIKDALGFLLLITLLLTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIAILAVMPLLHTSKQRSMAFRPISQCLFWILVADLFTLTWIGGQPVEHPFIIIGQLASFLYFFLILILMPTCSLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PSRP_XANCP
Sequence: MSTIRPVFYVSDGTGITAETIGHSLLTQFSGFNFVTDRMSFIDDADKARDAALRARAAGERYQVRPVVVNSCVDPQLSMILAESGALMLDVFAPFIEPLERELNAPRHSRVGRAHGMVDFETYHRRINAMNFALSHDDGIALNYDEADVILVAVSRAGKTPTCIYLALHYGIRAANYPLTEEDLESERLPPRLRNYRSKLFGLTIDPERLQQIRQERRANSRYSAAETCRREVATAERMFQMERIPTLSTTNTSIEEISSKVLSTLGLQREMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: OFUT1_DROME
Sequence: MQWLKMKLRFVNLILLLISSTCAQLGGDPNGYLTYCPCMGRFGNQADHFLGSLAFAKALNRTLILPPWVEYRRGELRSRQVPFNTYFEVEPLKEYHRVITMADFMWHLADDIWPESERVSFCYKERYSLQQEKNDPDKPNCHAKDGNPFGPFWDTFHIDFVRSEFYAPLHFDVHHSNEAAKWQTKYPAESYPVLAFTGAPASFPVQLENCKLQRYLQWSQRYREASKDFIREQLPRGAFLGIHLRNGIDWVRACEHVKDSQHLFASPQCLGYKNERGALYPELCMPSKEAIIRQLKRTIKNVRQTQPDNEIKSVFVASDSNHMIGELNTALSRMGISVHKLPEDDPYLDLAILGQSNHFIGNCISSYSAFEKRERDVHGFPSYFWGFPKEKDRKHTNVHEEL
What is the function of this protein?
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines (PubMed:12909620).  Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer (By similarity).  Plays a crucial role in Notch signaling (PubMed:12917292, PubMed:12909620, PubMed:17329366).  Initial fucosylation of Notch/N by O-fut1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats (PubMed:12909620).  This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Serrate/Ser (PubMed:12909620, PubMed:12917292).  Also required for the transport of Notch/N to the early endosome (PubMed:17329366).
What are the official names of this protein?
GDP-fucose protein O-fucosyltransferase 1, Neurotic protein, Peptide-O-fucosyltransferase 1, O-FucT-1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 65 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: CLPT4_CHLRE
Sequence: MQALQASRLTGQARPCSSSVVPRCSSLHVSRPISSGVSSSQELSSRSSAPATKSWRSSGRVITRATATAAPSELDDVGVSAAAESIIQYAINFARASETYEVHSWMVLMGILKYETCTAAKILKSLGLEDLYGAWNEVLWALNVCDGLQPRSFVTDIKFADRAFKVITAASDFAVWHGKDKMYSEDVLMALAAGGVLEDLFPDLNLSFERVRKAVEKESGRRYQLPDETEEAGPLKSEDDVSFL
What is the function of this protein?
Accessory protein regulating the assembly of the plastid Clp protease system.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SUB12_TRIVH
Sequence: MSIFKMMLIYFAILWVVNAAQLLDIDPQGVIPGAYIVVMKDRVSSLEFSSHVRWLKRTHRRNLAKRAIPFTEGLSATWDIAGWQAYSGSFDEDTVQEILNHENVEFVEPNKEMQVASTIKQGNVTWGLSRISHKENSSHDYVSTYGEGENITFYGIDSGIDINQADFTGRARWGINLADHVDTDCNGHGTHTAGTVAGQKFGILKKASIVSIKILDCYGYGDITRYINGLNWAINDAKERGLLGKSVMNISLKTGRSRAVNEATVRAQEAGIFIAVAAGNQATSAEFYSPGSAPEVCTVGASTRNDTKAIFSNYGELVDLFAPREYIRSTLPHNLTGLMSGTSMATPHVCGVGGLIMATEGLAPEKVCDRLKELANPTIQNPGFNTTNKLLYNGSGA
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 12.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DRE22_ORYSJ
Sequence: MAATAAALAVTDELALPLRAVGDLAAAAGFSREEVVVITQCASLGGKLPFDDASVGSVLAVIKKVENLGDLFITEISRVLKAGGMVLIQSSPSDQDPNNSIQRKLLLGGFVDVQASAASSQDSEHSVTIKAKKVSWSMGSSFPLKKATKGLPKIQIDDDSELIDEDSLLTEDDLKKPELPVVGDCEVGATRKACKNCTCGRAEAEEKVEKLNLTSEQINNPQSACGNCGLGDAFRCGTCPYRGLPAFKPGEKIALPGNFLAADL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog 2, Fe-S cluster assembly protein DRE2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: PSBC_DIOEL
Sequence: MKTLYSLRRFYPVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVLKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRAFVWSGEAYLSYSLGALSVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLGRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDLEPVLSMTPLS
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y2171_CITK8
Sequence: MSIYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQESLATWQVGMVSSSYFTGNLVGTLLTGYLIKRLGFNRSYYIASLIFAAGCVGLGMMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVPTELMSVLPWVTGMILAGILPLLFTRILNQQSEEHDTTPITSMLRLRQARLGVNGCIISGIVLGSLYGLMPLYLNHQGISNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVERHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNYSDNLLFIMIASVSFVYLLMLLRNAGHTPTPVAHV
What are the official names of this protein?
Uncharacterized MFS-type transporter CKO_02171.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DER_COXBR
Sequence: MLPVIAIVGRPNVGKSTLFNYLTKSRAALVADVPGVTRDRQYGETTIDSQRLLLVDTGGLVDTENKEVAPLAETQVEQAIDESDCILFLVDAKAGLVPADEIIAERLRKKGKKIFLAVNKADRARAAVVQSDFYKLGFGEPYVIAAASGRGVKDLMTQVLENLPEEKEVIEKEVGIKIAMIGRPNVGKSTLINRLLGEERVIVYDQPGTTRDSIYIPFARNDENYTLIDTAGIRRRAKIQDYVEKFSMIKSLQAMHAADVVIFLLDARQGVTEQDLRLLNRIVEAGVSLIIAVNKWDGLNIEERDNVRNAIDRRMPFVDFARRYFISALHGTGVGKLFRAIQESYQSIQQELTTGQLTRALEKAVAEHEPPLVKGRRIRLRYAHLGARHPLTIVVHGKQTKSLPQSYSRYLANYFRKTFNFIGVPVHIKLKTDPNPYEGQEER
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.