PharMolix/UniProtQA huggingface dataset:
Protein: DUS5_RAT
Sequence: MKVTSLDGRRLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLADEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLSAGPRVYFLKGGYETFYSQYPECCVDAKPISQEKLEGERGLLSQCGKPILSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFEYIKQRRSVVSPNFGFMGQLLQYESEILPSTPTPQPPSCQGEAASSTFIGHLQTLSPDMQGAYCTFPTSVLAPVPTHATVAELHRSPVATATSC
What is the function of this protein?
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues.  The highest relative activity is toward ERK1.
What are the official names of this protein?
Dual specificity protein phosphatase 5, MAP-kinase phosphatase CPG21.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1856_MYCTO
Sequence: MEVLVTGGDTDLGRTMAEGFRNDGHKVTLVGARRGDLEVAAKELDVDAVVCDTTDPTSLTEARGLFPRHLDTIVNVPAPSWDAGDPRAYSVSDTANAWRNALDATVLSVVLTVQSVGDHLRSGGSIVSVVAENPPAGGAESAIKAALSNWIAGQAAVFGTRGITINTVACGRSVQTGYEGLSRTPAPVAAEIARLALFLTTPAARHITGQTLHVSHGALAHFG
What are the official names of this protein?
Putative oxidoreductase MT1904.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: KDSB_IDILO
Sequence: MSFTVVIPARYGSSRLPGKPLADIAGKPMIQHVVERAEASGAAEVIVATDDMRIKEGVDKFGGRVMMTSSEHSSGTERLAEVIEQLALAENEVVVNVQGDEPFIPPEIIRQVADNLANQRQAPMATLAVPITDAEDIFNPNTVKVVTDAAGYALYFSRAAIPWDREHFSADRATNVVTEHYHRHIGIYAYRAGFVRRYIEWEPSPIEQLESLEQLRVLWHGERIHVAEAILAPATGIDTEEDLQRARKLAGDG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_ECO45
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RIBL_THEON
Sequence: MEKRERKKIRVLAGGVFDLLHVGHIHFLSQAKSLGDELVVIVAHDETVRMQKRREPVNPAEDRAELLRALKMVDEVYIGSPGTIDYELVRKINPDIVAIGPDQRFSCERLKEELRKHGINSEVIRIPYLYKEDRAKTSKIIQRIVETYCE
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: METE_BUCBP
Sequence: MINNHTLGFPRIGLFRELKVAQEKYWSRKISKEELFSVGKTLRVRHWQQQKELGINYIPVGDFSWYDHVLGTSMLLGNIPKRHKNGNDLVTLDTLFRVARGVAPTGASVSASEMTKWFNTNYHYIVPEFSIKSEFCFSWRQILDEIDEALLLGHQVKPVILGPLTYLWLGKVKGKKFDRLNLLKEILPVYKYLLSEINDRNISWVQIDEPILTLELPEKWKNAFRFAYQSLYGYNSLLLTTYFGSVQHNFSLICELPIQGVHLDLVHGKYDLVFLNSFIPEKWLISLGIINGKNIWKADLVMWFKRLQLFSKLRHSLWIGTSCSLLHVPIDLKLENKISSEVRSWFSFALQKCQELTLLRDALNNSNTVTEDIRVWSQPIHSRKKSAIVHNVDVKERLKSITSNDFKRNNVFSVRKQKQHKNLKLPILPTTTIGSFPQTADIRKARFDFKKGNINHDQYNTFISKHIQNAILKQEKLGIDVLVHGEFERNDMVEYFGEHLNGFVFTEFGWVQSYGSRCVKPPIIIGDVSRSKPISLDWIKYAQTLTSKPVKGMLTGPVTILLWSFVREDLSKKIISRQIALALRDEVLDLEQSGVKIIQIDEPALREGLPLRLSLRNEYLSWAVDSFKLSSSGVCDETQIHTHMCYCEFNDIMNAIVLLDADVITIETSRSDMELLEFFKEFKYPNDIGPGVYDIHSPNIPSIEWIMTLLRQAMHYIPVKRLWVNPDCGLKTRTWDETYYSLENMVRAAKILRKKL
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: OR2V1_HUMAN
Sequence: MGRWVNQSYTDGFFLLGIFSHSQTDLVLFSAVMVVFTVALCGNVLLIFLIYLDAGLHTPMYFFLSQLSLMDLMLVCNIVPKMAANFLSGRKSISFVGCGIQIGFFVSLVGSEGLLLGLMAYDRYVAVSHPLHYPILMNQRVCLQITGSSWAFGIIDGVIQMVAAMGLPYCGSRSVDHFFCEVQALLKLACADTSLFDTLLFACCVFMLLLPFSIIMASYACILGAVLRIRSAQAWKKALATCSSHLTAVTLFYGAAMFMYLRPRRYRAPSHDKVASIFYTVLTPMLNPLIYSLRNGEVMGALRKGLDRCRIGSQH
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2V1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTO1_YEAST
Sequence: MLRVTTLASSCTSFPLQVLRRRLTISSLTSFQPTTKTQVVVIGAGHAGCEAAAASSRTGAHTTLITPSLTDIGKCSCNPSIGGVGKGILVKEIDALDGLMGKVTDLAGVQFKMLNRSKGPAVWGPRAQIDRELYKKYMQRELSDKKAHPNLSLLQNKVADLILYDPGCGHKVIKGVVLDDGTQVGADQVIITTGTFLSAEIHIGDKRIAAGRIGEQPTYGISNTLQNEVGFQLGRLKTGTPARLAKESIDFSALEVQKGDALPVPMSFLNETVSVEPTKQLDCFGTHTTPQMHDFLRNNLHQSIHIQDTTIKGPRYCPSIEAKILRFPDRSSHKIWLEPEGFNSDVIYPNGISNSMPEDVQLQMMRLIPGMANVEILQPAYGVEYDYVDPRQLKPSLETKLVDGLFLAGQINGTTGYEEAAAQGIIAGINAGLLSRQEREQLVLKRSEAYIGVLIDDLINNGVIEPYRMFTSRSEFRISVRADNADFRLTPIGAQLGIISPVRLSQYSRDKHLYDETIRALQNFKLSSQKWSSLLQANIAPQAENRSAWEIFRFKDMDLHKLYECIPDLPINLLDIPMHVVTKINIQGKYEPYIVKQNQFVKAFQADENMLLPQDYDYRQLPTLSTECKLLLNRVQPLTIGQARRIQGITAAALFELYRVARKPSQPVM
What is the function of this protein?
Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
What are the official names of this protein?
Mitochondrial translation optimization protein 1.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
Protein: DNAS1_RAT
Sequence: MRYTGLMGILLTLVNLLQLAATLRIAAFNIRTFGDTKMSNATLSSYIVKILSRYDIAVVQEVRDTHLVAVGKLLDELNRDIPDNYRYIISEPLGRKSYKEQYLFVYRPSQVSVLDSYHYDDGCEPCGNDTFSREPAIVKFFSPYTEVREFAIVPLHSAPTEAVSEIDALYDVYLDVRQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTATSTHCAYDRIVVAGALLQAAVVPSSAVPFDFQAEYRLTNQMAEAISDHYPVEVTLRKT
What is the function of this protein?
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:8428592, PubMed:15796714).  Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (PubMed:15796714).  Among other functions, seems to be involved in cell death by apoptosis (PubMed:8428592, PubMed:15796714).  Binds specifically to G-actin and blocks actin polymerization (By similarity).  Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity).  NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).  Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
What are the official names of this protein?
Deoxyribonuclease-1, Deoxyribonuclease I, DNase I.
What is the protein family that this protein belongs to?
Belongs to the DNase I family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Protein: RS3A_METB6
Sequence: MAKKKQAGRRVEGWKAKSWFKVYTPDNLGKAYIGDTIASEVETVKGRIMQATLGEITNDYAKQHIKMSFKIAEVTGDAAYTEFVGHEVTRDYLRSLVKRRSSRIDCHVQVVTKDNKKVRLTISCYTFARANIAQEHALRNAITAGLVAQAQAWDLNTLVNGVVSGEISKDLFKLVKTLYPTRRVEIIKSKVEQVAAPVSTA
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: DPOL_CBEPV
Sequence: MKLKKLYIFYFDIYEYFLCDLQLSETNEILKYIKNNIDKYTNSFNSSYIILKDFNIITNEVELQSYYNFTEDSKIKLNNTDLILFMTPYKIERIYSKYNRNFNQYRWFYILNNIEPAGSYKINMSNLQNINIYDKNKTAYYCKNPKLLFLTPIEIDKFIPVSRVSIDIECQHFGEFPTPNKFPISHICIDWFMESNINPVKKIITLINYEIIKNYKGEQKDRFIYTEIDELLTKDKVYITIYCTEKYMLHFILYTLRKDFDYILTYNGHSFDFTYIQGRRKFYNLNELCLVNAHKSNELKIYSYNKDTTYEIDSNNGIIFLDLYNYIKKIYNYNSYKLGEIAKERFNILSKIIDNGDEYIIMPLDTADNKNKVSIFYDVIRTANYCFINNIPYKIKDKTKIINDKEKLYDPISIENSLYQQFKIYKNNTPISDETTKVMLSKDDVDIGNKNAYVNFTKDKSDDIAYYCTHDTVLCNCIFKYDMIHDKVIAFSNEYLLPQYMSFKYKSTTNISGLLLKTLFCNRSMIVSGNLEFEKFEGGYVLEPKQKYIDSITAVFDFNSEYPSNIIEANLSPEKVEKVIKLQDDEYAVDIVENYLKEKYPYPDYCYMLIKKDKTYKFIVMDRRKPGIITQMIDKGMKSKNEYKNLKNINKNNPVLYNYYTSALYSKKITINSLYGLLGSERFDFNSPYCAEYCTALGQKCIKYIKNLVDKSRYIDNNLYLNEQNNPFSNEPVITRYSGNLDVNFTFYIIYGDTDSLFINIKFDNKFDNKEDLVNKSHECFQFLSNIINDEKNIILSKNFNFEYEKMYIWMLLLAKKKYIGEVVSSMNPLQLISDSKGTALIRRDCTEIHKTILKNTIDILKEYLTNNCTIQDVNNKINNYLMFTFKNIIENIQNLDINEFKKSVKYTGIYKDPNFYIELCVKKYNSKNPNDKIVKGQRFDFIYAHEIDIWDIETKKWNTKYTS
What is the function of this protein?
Catalyzes DNA synthesis.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: LPXD1_RHOPB
Sequence: MAQPSFFKQGPSSTLAEIAALTKAELVDASRADHRITGVASLDEAGPMHLGFFENIKYAGQLAQTRAGAVLVSPRFEASVPPHVAVLRAKSPFRAFVAYARLIHQDAMRPQSGFDLTGIAASAVIHPTARLEDGVTVDPLAVIGPQVEIGAGSVIGSGAVLSPGVRIGRDCNVGAGTVIQFALIGNNVLIHPGCQIGQDGYGFIFAETHQKVPQTGRVIIQNDVEIGAGTTIDRGSLRDTVIGEGSKIDNQVQIGHNVTIGRHCLIAAQCGLAGSLTLGDNVALGAKVGINNHLHIGDGAQVTAMSAVKDDVPANGRWGGYFAKPTKQWFREILAVERLPKSGAPGADSKDAKGERQG
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: AUR44_RANRN
Sequence: GLLQTIKEKLKELATGLVIGVQS
What is the function of this protein?
Has no antimicrobial or anticancer activity.
What are the official names of this protein?
Aurein-4.4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Aurein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_RICBR
Sequence: MAVKIRLARGGAKKRPFYRVVVANATAPRDGDFLEKVGTYNPMLAKDSNERVVLKADRVEYWLKSGAKPTDRVARFIEQAGIALPEKVKKEMEVKLKNRKAKPSKKEAKEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SAPC_SALTI
Sequence: MPYDSVYSEKRPPGTLRTAWRKFYSDAPAMVGLYGCAGLALLCIFGGWIAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGTDDLGRDVLSRLLSGAAPTVGGAFIVTLAATLCGLVLGVVAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPHLSHAMFAVWLALLPRMVRSVYSMVHDELEKEYVIAARLDGATTLNILWFAILPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDALELIYVAPWTVMLPGAAITLSVLLVNLLGDGIRRAIIAGVE
What is the function of this protein?
Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
What are the official names of this protein?
Peptide transport system permease protein SapC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PACR_BOVIN
Sequence: MRGGRHWPEPPCRLRSVMASIAQVSLAALLLLPMATAMHSDCIFKKEQAMCLEKIQRVNDLMGLNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGEFGFADSKSLDLSDMRVVSRNCTEDGWSEPFPHYFDACGFEEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYIIIGWGTPTVCVSVWAMLRLYFDDTGCWDMNDNTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
What is the function of this protein?
This is a receptor for PACAP-27 and PACAP-38.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine.  May play a role in spermatogenesis and sperm motility.  Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity).
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP type I receptor, PACAP-R-1, PACAP-R1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABH_WOLPP
Sequence: MSKSFILSTGSYLPKKILSNNEIALIVETNDEWIRQRTGIVQRHIADEGELTSDLAVNAAKNAIEKAKISIDEIGLIIVATTTPDKTLPSCATIVQSKLKCKNAFSFDVQAACSGFIYAVTVADSLIKSHNRIKYALVIGAEIMSRIVDWEDRSTCVLFGDSAGAVIIKSEMGSSGIISTNLHSDGNVDILCTNGGVSSTRDSGKILMNGREVFKHAVDKLTASVEETLKCNNLKIIDIDWLIPHQANIRIIEAVVKKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLLRY
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_CHLTR
Sequence: MTVQNVRVRVAPSPTGDPHVGTAYMALFNEVFARKYNGQMILRIEDTDQTRSRDDYEANIFSALKWCGIRWDEGPDVGGAYGPYRQSERTEIYKKYAEILLQTDCAYKCFATPQELQEMRAVASTLGYRGGYDRRYRYLSPEEVRQREEQGQPYTIRLKVPLTGESVFEDQCKGCVVFPWADVDDQVLVKSDGFPTYHFANVVDDHLMGITHVLRGEEWLSSTPKHLLLYEAFGWEPPQFFHMPLLLNPDGSKLSKRKNPTSIFYYRDAGYKKEAFMNFLTLMGYSMEGDEEIYSMQRLIEAFDPKRIGRSGAVFDIRKLDWMNKHYLNHEGSPESLLQELKGWLWNDEFLLKILPLCQSRITTLADFVGLTSFFFTAIPQYSKEELLPSSLKQEQAAVMLYSLVKYLEKKDLWEKDFFYQGSKWLAEAFQVHHKKAVIPLLYVAITGAKQGLPLFDSMELLGKARTRARLTYAQNLLGGVSKKVQQQVDKALQDQPLEDIRFLDF
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_ECO8A
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KVD39_HUMAN
Sequence: MDMRVPAQLLGLLLLWLRGARCDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1D-39, Ig kappa chain V-I region Daudi.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: ATPB_LIRTU
Sequence: MRINPTTSSPGVSTLEEKNLGRIVQIIGPVLDVAFPPGKMPNIYNALVVKGRDTVGQQINVTCEVQQLLGNNRVRAVAMSATDGLMRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTSQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLEVESKLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ATG4_PICPA
Sequence: MYRFLGLGTHPNDDQNKIHVLGRQYDPIKTQETEGKDLDLNSRFQQVLDSIKDGNKKSTTYSQSFIDDVYSKIWLTYRAGFPPIARDKDSPTFTLGALLRGQFDFNEIGFTSDAGWGCMIRTSQSLLANALLFLHLGRDWVFKAKDPANVEHDRIISWFVDIPDEPFSIHNFVQQGIKCCDKKPGEWFGPSAASRAIKNLCKEYPPCGLRVYFSSDCGDVYDTEVRELAYGDSDTFTPILVLLGIRLGVEKVNLYIGDLLRECLSLKQSVGISGRKTSFLALLSIGFQGDYLFYLIPTFPKKALTFGKHGEPVHRLQTKKTDENAAGQYPVFKYWIQIMKQTMMTAMKASKTTASTLKFFRVLMSNQSTHQKVTKLHLSHMDPSMLIGFLITSEDDFNDWKENIGKKDPSHKIVHITETKVSESTSNFQFNSLRSNSIADYDNCSGEDCDSAAIASDSDDFVDLAADFAVTGLEPRTHTGVDDETSSDYVQHFPIRRFSQPVIVSREDVVPTLSEDNGVIALDDKMSGISVGR
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4, Pexophagy zeocin-resistant mutant protein 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: APC5_SCHPO
Sequence: MQSPAMSMVTPIFPIPLKTNSSKKNFYTTFLTPHKLTLCLLIELYAHRIIQPQHCVPFLDLVLGYFNPNDSQPQTLTRIHDITSHLPSSIEEYSVYSLLHERLWSLHSFEDIHEIFISLGNYIEGVYDSEEEAPHMLFSSSSLLSIFLRKCVVEYEQFSFEQGVQFFKSFLQYRAPSMDFQHEGIEFCKINVRHELMNLASNKTLLQLAFGSIPVSRSSRDIEQLTQVQIEHMQKFGCALPLEMKEKLHDLLEVEENNLNTSYYCKFLNSWFSGDYQQSVENLCRYFDHIMHSDEKVSYQYALLNLAMLQADFGCNEEALHAIEDTINTARESGDTACLNFALAWMFEFKRSQYSNPSPEKNENDDQILEHLARNSQKAQLPILQTTVHLLQVQKFLDDGSSLIGVFSNLTKAFALFCANESFDGFPRYMDLLQSIWYRLGCSILSMTYISIYQKNHVHDSPALDLLQSLITKAWRYAELGRWLDVATILSTAEVQSQRSFQCAHLYGREKTFIYLSKAIDEKNHMDATLYLKNLNGFRHDKMSTFRTQLYALRLDISLGNLSQAIEGIDKLLEEPEKLAIEWVLQLMFLKVDIYMRTEMSNRAVFELLEIIQMASSNYLRLYLLRGLCTLCLIGELDCFTAIDLLDSLIPDIIAADNKPLLALAFHAFASLQIKHLDLLQPSRMFVIQLLDSAIDGYRACYMVEMQKTVVRLKIQYLRQINDPALQPNIEQYCSRFYSDNLLN
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
What are the official names of this protein?
Anaphase-promoting complex subunit 5, 20S cyclosome/APC complex protein apc5.
What is the protein family that this protein belongs to?
Belongs to the APC5 family.
Protein: PER30_ARATH
Sequence: MKTMTQLNIAVVVVVTVLIGMLRSSEAQLQMNFYAKSCPNAEKIISDHIQNHIHNGPSLAAPLIRMHFHDCFVRGCDGSVLINSTSGNAERDAPPNLTLRGFGFVERIKALLEKVCPKTVSCADIIALTARDAVVATGGPSWSVPTGRRDGRISNKTEATNNIPPPTSNFTTLQRLFKNQGLNLKDLVLLSGAHTIGVSHCSSMNTRLYNFSTTVKQDPSLDSQYAANLKANKCKSLNDNSTILEMDPGSSRSFDLSYYRLVLKRRGLFQSDSALTTNSATLKVINDLVNGSEKKFFKAFAKSMEKMGRVKVKTGSAGVIRTRCSVAGS
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 30, Atperox P30, ATP7a, PRXR9.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.