PharMolix/UniProtQA huggingface dataset:
Protein: DNBI_HHV2
Sequence: MDTKPKTTTTVKVPPGPMGYVYGRACPAEGLELLSLLSARSGDADVAVAPLIVGLTVESGFEANVAAVVGSGTTGLGGTAVSLKLMPSHYSPSVYVFHGGRHLAPSTQAPNLTRLCERARRHFGFSDYAPRPCDLKHETTGDALCERLGLDPDRALLYLVITEGFREAVCISNTFLHLGGMDKVTIGDAEVHRIPVYPLQMFMPDFSRVIADPFNCNHRSIGENFNYPLPFFNRPLARLLFEAVVGPAAVALRARNVDAVARAAAHLAFDENHEGAALPADITFTAFEASQGKPQRGARDAGNKGPAGGFEQRLASVMAGDAALALESIVSMAVFDEPPPDITTWPLLEGQETPAARAGAVGAYLARAAGLVGAMVFSTNSALHLTEVDDAGPADPKDHSKPSFYRFFLVPGTHVAANPQLDREGHVVPGYEGRPTAPLVGGTQEFAGEHLAMLCGFSPALLAKMLFYLERCDGGVIVGRQEMDVFRYVADSGQTDVPCNLCTFETRHACAHTTLMRLRARHPKFASAARGAIGVFGTMNSAYSDCDVLGNYAAFSALKRADGSENTRTIMQETYRAATERVMAELEALQYVDQAVPTALGRLETIIGNREALHTVVNNIKQLVDREVEQLMRNLIEGRNFKFRDGLAEANHAMSLSLDPYTCGPCPLLQLLARRSNLAVYQDLALSQCHGVFAGQSVEGRNFRNQFQPVLRRRVMDLFNNGFLSAKTLTVALSEGAAICAPSLTAGQTAPAESSFEGDVARVTLGFPKELRVKSRVLFAGASANASEAAKARVASLQSAYQKPDKRVDILLGPLGFLLKQFHAVIFPNGKPPGSNQPNPQWFWTALQRNQLPARLLSREDIETIAFIKRFSLDYGAINFINLAPNNVSELAMYYMANQILRYCDHSTYFINTLTAVIAGSRRPPSVQAAAAWAPQGGAGLEAGARALMDSLDAHPGAWTSMFASCNLLRPVMAARPMVVLGLSISKYYGMAGNDRVFQAGNWASLLGGKNACPLLIFDRTRKFVLACPRAGFVCAASSLGGGAHEHSLCEQLRGIIAEGGAAVASSVFVATVKSLGPRTQQLQIEDWLALLEDEYLSEEMMEFTTRALERGHGEWSTDAALEVAHEAEALVSQLGAAGEVFNFGDFGDADDHAASFGGLAAAAAGAAGVARKRAFHGDDPFGEGPPEKKDLTLDML
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: G6PD_BUCAP
Sequence: MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKIVKKAIKMFLNEKIDEKIWKKLRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPSNTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINNQIAKYFLESQIFRIDHYLGKESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLLQILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSYIEENGANKHSKTETFVSIKVDINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQEFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKSDKMEFNFNINNTKNFVDAYERLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIMRDGRFWETFN
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: ODBA_THET8
Sequence: MVKETHRFETFTEEPIRLIGEEGEWLGDFPLDLEGEKLRRLYRDMLAARMLDERYTILIRTGKTSFIAPAAGHEAAQVAIAHAIRPGFDWVFPYYRDHGLALALGIPLKELLGQMLATKADPNKGRQMPEHPGSKALNFFTVASPIASHVPPAAGAAISMKLLRTGQVAVCTFGDGATSEGDWYAGINFAAVQGAPAVFIAENNFYAISVDYRHQTHSPTIADKAHAFGIPGYLVDGMDVLASYYVVKEAVERARRGEGPSLVELRVYRYGPHSSADDDSRYRPKEEVAFWRKKDPIPRFRRFLEARGLWNEEWEEDVREEIRAELERGLKEAEEAGPVPPEWMFEDVFAEKPWHLLRQEALLKEEL
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit alpha, Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDH E1-alpha.
What is the protein family that this protein belongs to?
Belongs to the BCKDHA family.
Protein: ISDB_STAAN
Sequence: MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKAVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
What is the function of this protein?
Cell wall-anchored surface receptor that extracts heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (PubMed:24645787).  Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization (PubMed:24645787, PubMed:21574663, PubMed:29109153).  Promotes also resistance to hydrogen peroxide and killing by neutrophils (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein B, Fur-regulated protein B, Staphylococcal iron-regulated protein H, Staphylococcus aureus surface protein J.
What is the protein family that this protein belongs to?
Belongs to the IsdB family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Protein: ACON2_SCHPO
Sequence: MATFARMKLCLSGSSQAIPSKGISLVAARFQSTASRASYVTPPYEKLMGKLQQVRKFLPGQKLTLAEKVLYSHLVNPEESFSGVSPSDIRGSLYLKLNPDRVAMQDASAQMALLQFMTCGLEKTMIPASIHCDHLIVGHRGANSDIPDSIANNKEIFDFLQSAAKKYGIQFWGPGSGIIHQIVLENYAAPGGMMLGTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVNLTGAMSGWTTPKDLILHLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGATTSIFPYTDSMRRYLIATHRAEVADAASEVHSEYNYLAADTGAKYDQIIDINLSELTPSLNGPFTPDLSTPVSKFGEAIEKNKWPKKLSAGLIGSCTNSSYQDMTCVVDVVEQAISAGLKPKVPFLVTPGSEQIRATIERDGITERLEEAGATVLANACGPCIGMWKRTDDIASGEPNAILTSFNRNFRSRNDGNPSTMNFLTSPVIVAAKIFSSDLAFDPTHDTLQTPDGKAFKFRPPQGVELPSAGFIAGDSSYIPEPNPQPVPETEVTIDPKSDRLEALEPFEPYQGGEMENLKVAVKVKGKCTTDHISAAGKWLKYKGHLSNICNNTLIGAMNAATGEVNRAYDNGKGMTIPELMWKWKKDGQPWLVVAEHNYGEGSAREHAALQPRAMNGRIILTKSFARIHETNLKKQGVLPLTFVNEADYEKIDAEDKVSTRGIEQLLEGVLDQPITLVVTKKDGSVVEIPCKHTMSKDQIEFFKAGSALNLIREKAHSGVVNQKVIDSIKQQPDHYADAYIFNRHFVIAKGDQLGLPFHLKGVQVGDTIRLDKIASFGSRDFTLFGNPYVDPSLFTIEAVVLSFPKSALSVRVKHKRRHRHDRVMKHKQTYTILRVTELKLN
What is the function of this protein?
Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
What are the official names of this protein?
Homocitrate dehydratase, mitochondrial, Aconitase 2.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YG64_YEAST
Sequence: MAATPAAIEVSLTIVFVLFFSADVSLTRNSEMKAHTSKMDSYSSSIYMNVLPTSLAQTSYHLAPISHLKCLSVQCSSHIHYSYYYGASVLERCVFHRSRIRGARFIVPIPFYCISKAQECFLTVYILPKNPFRVPSEMQLQLLAKKKLKPNLL
What are the official names of this protein?
Putative uncharacterized protein YGR293C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NOP10_METM6
Sequence: MKMKKCPKCGKYTLKDFCSECNEKSVTVKPPKFSPVDKYGKYRRALKKAKM
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: ACLN_ASPOR
Sequence: MSRSTMLAHSAIPSSLIRMDLLSPWILTATAPKFLRLFAPATRRRSARSTIPSWSRSSSGKQAHHAWLSSITPCDGARSPWLARIPMAASSLQAQSPLGARRRVYQHLPEEADRLLKGRAQIVNVWRPLRGPVQDWPLAVMDCSTLAQAHIHPTKLYRNRFELRGETVSISHDESQRWYYLDGQQTDECTLIKIWDSKEGISGHMCAHCAFQHPNTPVDAPLRESVEVRCLVFYENQE
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Aspirochlorine biosynthesis protein N.
What is the protein family that this protein belongs to?
Belongs to the asaB hydroxylase/desaturase family.
Protein: YHH5_SCHPO
Sequence: MKPFSPSQTNFEKEQLCFGVYQLKDCYQQVIEALSLGIRVIDSAITYRNEKECEQAIQDFCHQNVNIKREDITLITKIPDSLQGFERTWKAVEQSLRRTGRPKLDVVLIHSPKWPVRRIESWRALLQHQKEGRINKIGVSNYNIHHLEEIISLGLPLPAINQVEFSAFNNRPTFLSYCFNHGILVQAFSPLTRGYRLSDIRLLDLSLKYNKTPANILLRYCLQKGVSPIFKASSFVHIHENVKAEQFMLDPSDMDVMDTWDEEFVSKPTWNPIILP
What are the official names of this protein?
Uncharacterized oxidoreductase C28F2.05.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GH43A_BACO1
Sequence: MRNALFLIFISLCSVCKSSAQGYSNPVIPGFHPDPSVCKAGDDYYLVNSSFQYFPGVPLFHSKDLVHWEQIGNCLTRPSQLDLTNANSGSGIFAPTIRYNDGVFYMITTNVSGKGNFLVHTTDPRSEWSEPVWLEQGGIDPSLYFEDGKCFMVSNPDGYINLCEIDPMTGKQLSSSKRIWNGTGGRYAEGPHIYKKDGWYYLLISEGGTELGHKVTIARSRYIDGPYQGNPANPILTHANESGQSSPIQGTGHADLVEGTDGSWWMVCLAYRIMPGTHHTLGRETYLAPVRWDKDAWPVVNSNGTISLKMDVPTLPQQEMKGRPERIDFKEGKLSPEWIHLQNPEAKNYIFTKDGKLRLIATPVTLSDWKSPTFVALRQEHFDMEASAPVVLQKAGVNDEAGISVFMEFHSHYDLFVRQDKDRKRSVGLRYKLGEITHYAKEVSLPTDGEVELVVKSDINYYYFGYKVNGIYHDLGKMNTRYLSTETAGGFTGVVLGLYITSASKDSKAYADFEYFKYKGKPGENK
What is the function of this protein?
Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches, converting the 'S' units to 'X' units.
What are the official names of this protein?
Non-reducing end alpha-L-arabinofuranosidase BoGH43A, Glycosyl hydrolase family protein 43A, BoGH43A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
What are the subcellular locations of this protein?
Periplasm. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus.
Protein: RSMH_SHEHH
Sequence: MTQEFEHLSVLLTETVAGLNIKPDGIYIDGTFGRGGHSRKVLEELGPNGRLIAIDRDPQAIAAAEQFKDDSRFQIVHGGFGQLADYVEDLGLKGKIDGVLLDFGVSSPQLDDAERGFSFLRDGPLDMRMDNSQGQTAAQWLARAEIEDMAWVFKTYGEEKNSRHIARCIAADREKAPFLRTKELADLIARITKNKERNKHPATRVFQAIRIYINSELEQIDQALEGALTVLAPEGRLSVISFHSLEDRMVKRFIRRNSQGESVPHGLPITEEEINKSRKLKGVGKAIKPSAEEIERNARARSSVLRIAQRLPYEA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_YEAST
Sequence: MHNIQLVQEIERHETPLNIRPTSPYTLNPPVERDGFSWPSVGTRQRAEETEEEEKERIQRISGAIKTILTELGEDVNREGLLDTPQRYAKAMLYFTKGYQTNIMDDVIKNAVFEEDHDEMVIVRDIEIYSLCEHHLVPFFGKVHIGYIPNKKVIGLSKLARLAEMYARRLQVQERLTKQIAMALSDILKPLGVAVVMEASHMCMVSRGIQKTGSSTVTSCMLGGFRAHKTREEFLTLLGRRSI
What is the function of this protein?
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: LDCA_ECOL6
Sequence: MSLFHLIAPSGYCIKQHAALRGIQRLTDAGHQVNNVEVIARRCERFAGTETERLEDLNSLARLTTPNTIVLSVRGGYGASRLLADIDWQALVARQQHDPLLICGHSDFTAIQCGLLAQGNVITFSGPMLVANFGADELNAFTEHHFWLALRNKTFTIEWQGEGPTCQTEGTLWGGNLAMLISLIGTPWMPKIENGILVLEDINEHPFRVERMLLQLYHAGILPRQKAIILGSFSGSTPNDYDAGYNLESVYAFLRSRLSIPLITGLDFGHEQRTVTLPLGAHAILNNTQEGTQLTISGHPVLKM
What is the function of this protein?
Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala.  Can also cleave D-Ala from murein derivatives containing the tetrapeptide, i. e.  MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide.  Does not act on murein sacculi or cross-linked muropeptides.  The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling (By similarity).
What are the official names of this protein?
Murein tetrapeptide carboxypeptidase, LD-carboxypeptidase A, Muramoyltetrapeptide carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S66 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_MYCUA
Sequence: MPTIQQLVRKGRRDKIGKVKTAALKRSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: HDA9_ARATH
Sequence: MRSKDKISYFYDGDVGSVYFGPNHPMKPHRLCMTHHLILAYGLHSKMEVYRPHKAYPIEMAQFHSPDYVEFLQRINPENQNLFPNEMARYNLGEDCPVFEDLFEFCQLYAGGTIDAARRLNNKLCDIAINWAGGLHHAKKCDASGFCYINDLVLGILELLKHHPRVLYIDIDVHHGDGVEEAFYFTDRVMTVSFHKFGDKFFPGTGDVKEIGEREGKFYAINVPLKDGIDDSSFNRLFRTIISKVVEIYQPGAIVLQCGADSLARDRLGCFNLSIDGHAECVKFVKKFNLPLLVTGGGGYTKENVARCWTVETGILLDTELPNEIPENDYIKYFAPDFSLKIPGGHIENLNTKSYISSIKVQILENLRYIQHAPSVQMQEVPPDFYIPDFDEDEQNPDVRADQRSRDKQIQRDDEYFDGDNDNDAS
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.
What are the official names of this protein?
Histone deacetylase 9, AtHDAC9.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Note=Localized to the cytosol when in complex with farnesylated ASG2.
Protein: CAV1_FELCA
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEEINEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPFFEAVGKIFSNIRINMQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: CSN6_HUMAN
Sequence: MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.  Has some glucocorticoid receptor-responsive activity.  Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.
What are the official names of this protein?
COP9 signalosome complex subunit 6, SGN6, Signalosome subunit 6, JAB1-containing signalosome subunit 6, MOV34 homolog, Vpr-interacting protein, hVIP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN6 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Protein: TRPC_PSEF5
Sequence: MSVPTVLEKILARKAEEVAERSARVSLAELETLARAADAPRGFARALQDQVKLKQPAVIAEIKKASPSKGVIRENFVPADIAKSYEKGGATCLSVLTDVDYFQGADAYLQQARAACKLPVIRKDFMIDPYQIVEARALGADCVLLIVAALDDARMAELAAVAKGVGLDVLVEVHDGDELERALKTLDTPLVGVNNRNLHTFEVNLETTLDLLPRIPRERLVITESGILNRADVELMEISDVYSFLVGEAFMRAESPGSELQRLFFPERGVPVSGSTLD
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: LEUD_AERS4
Sequence: MTGFKQHKGIAVPLDSANVDTDAIIPKQFLQKVNRIGFGKHLFHDWRFLDDAGQQPNPEFVLNQPRYAGASILLARENFGCGSSREHAPWALADYGFKTLIASSFADIFYGNAINNGLVPVRLKEEEVDLLFQLVATQPGIEIEVDLEANQVRAGELSFGFEIDEFRRYCLLNGLDAIGLTLQHEATISAFEAKQPSWI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: C82A4_SOYBN
Sequence: MELVLHFLNTTTIGVVSLIFLLCLFLYGPLKKVHGSSKEAPTVGGAWPIFGHLPLLIGSKSPHKALGALAEKHGPLFTIKLGAKKALVVSDWEMARECFTTNDVAVSARPKLLVAELMCYNNAMLLVAPYGPYWRELRKIIVTEILSSSRVEQLQDVRVSEVQNSIVELYDVWRSQKNESDYASVELKQWFAQPIFNMVLRMVVGKRFLSATATDEKAEKCVKAVDEFMRLAGVFTVGDAIPYLRWLDFGGYEKAMKETAKELDVMISEWLEEHRQKRALGEGVDGAQDFMNVMLSSLDGKTIDGIDADTLIKSTVLTIIQAGTEASISTIIWAMCLILKNPLILENKAELDIQVGKDRCICESDISNLVYLQAVVKETLRLYAPGPLSSPREFAEDCTLGGYHVKKGTRLITNIWKIHTDPNVWSDPFEFKPDRFLTTHKDIDVKGHHFQLLPFGSGRRVCPGISFGLQTVHLALASFLHSFEILNPSTEPLDMTEAFGVTNTKATPLEVLVKPCLSPSCYKSM
What are the official names of this protein?
Cytochrome P450 82A4, Cytochrome P450 CP9.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane.
Protein: YBIX_SHIF8
Sequence: MMYHIPGVLSPQDVAHFREQLEQAEWVDGRVTTGAQGAQVKNNQQVDTRSALYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPQSYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDKNIQSLKSRYGENEEILSLLNLYHNLLREWSEI
What are the official names of this protein?
PKHD-type hydroxylase YbiX.
Protein: CLPP_HUMAN
Sequence: MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
What is the function of this protein?
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process.  Has low peptidase activity in the absence of CLPX.  The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782).  Cleaves PINK1 in the mitochondrion (PubMed:22354088).
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, mitochondrial, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
Protein: Y2186_SULIL
Sequence: MDYWFAEIVTIGNEVLSGKTVNTNASHIGRRLTSLGFTVRRITVVMDDIDEIVSAFREAIDRKPKVIVSSGGLGPTWDDKTAEGLAKALGVNLELNKTAFDMILEKYTKRNIPLTEERKKMAYLPYGAMAVENNEGIAPGIYIYHNNIDILATPGVPREMENVLENFINKMLRNKPNLKYLEDFIYVENVMESALAPYVKELVKKYDIYIKTHPKSYELLRPILEIQIAGSGREEEIKVKIEKVKNELLDAIKKLNGIIRNSL
What are the official names of this protein?
Protein LS215_2186.
What is the protein family that this protein belongs to?
Belongs to the CinA family.