PharMolix/UniProtQA huggingface dataset:
Protein: SYL_KLEP3
Sequence: MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEISFDVNNYADKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAAFIDECRNTKVAEADMATMEKKGVDTGFKAIHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSAQALTEKGVLFNSGEFSGLDYEAGFNAIADKLAAMGVGERKINYRLRDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGQPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTTKGDVAALNVAALSEDQKALRRDIHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPQEDEQDRALMQEALLAVVRMLNPFTPHASFTLWRELNGEGDIDNAPWPVADESAMVEDSTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLDGKTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_MOOTA
Sequence: MSRIGKKPVKIPAGVEVNIEGNTVTVKGPKGKLTRQFPAEITISREGEELQVSRPSDAKPHRALHGLSRALLQNMVDGVTRGFEKGLELVGVGYRAAKQGNKLVLSVGYSHPVEMVPGEGLEIEVPAPNKVIVKGIDKEAVGALAAKIRDVRPPEPYKGKGIKYEGEYIRRKVGKTGAKGGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: EFG_CHLAD
Sequence: MPRQIELDKVRNIGIIAHIDAGKTTTTERILFYTGRTYKIGEVHEGTATMDWMPQEQERGITITAAATTAPWRLNGVEYRINIIDTPGHVDFTVEVERSLRVLDGGIVVFDGVAGVEPQSETVWRQADKYNVPRICFVNKMDRVGASFERCVQMIKDRLGAKPAVVQLPIGVEDTFRGTIDLFTMKATIYYDDLGKDIREEEIPAELRPAAEKARNELIEMIAETDDELTLLYLEGQELTVEELKRGLRKATIERKLVPVLCGAALRNKGVQKLLDAVVEYLPSPLDRPAITGTLPGQVMGDEGVEVITRRVSDDEPFTALVFKIVADPYVGKLAYFRVYAGKITKGSYVLNSTRGQRERLGRLLRMHANHREDIDEVYAGEIAAMVGPKNSYTGDTICDPDHPIVLESIRFPEPVIEMAIEPKTKADQDKMSIALSRLAEEDPTFRVYTDQETGQTIIKGMGELHLEVIVDRMRREYKVEANQGKPQVSYRETITVPVDQESRFVRQTGGKGQYGHVKIKFEPLPPGKGFEFVNAIVGGVIPKEYIPAVEQGLREAMQTGVIAGYPVVDLKATLYDGSYHEVDSSEMAFKIAASMCLKEAVRRGKPQLLEPIMKVETVTPEEFLGTVIGDFNSRRGRIEGIEARGNAQVVRAFVPLANMFGYMTDLRSATQGRATASMEFDHYEPLPEALAKEIIEKRSAN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUEO_ECOLI
Sequence: MQRRDFLKYSVALGVASALPLWSRAVFAAERPTLPIPDLLTTDARNRIQLTIGAGQSTFGGKTATTWGYNGNLLGPAVKLQRGKAVTVDIYNQLTEETTLHWHGLEVPGEVDGGPQGIIPPGGKRSVTLNVDQPAATCWFHPHQHGKTGRQVAMGLAGLVVIEDDEILKLMLPKQWGIDDVPVIVQDKKFSADGQIDYQLDVMTAAVGWFGDTLLTNGAIYPQHAAPRGWLRLRLLNGCNARSLNFATSDNRPLYVIASDGGLLPEPVKVSELPVLMGERFEVLVEVNDNKPFDLVTLPVSQMGMAIAPFDKPHPVMRIQPIAISASGALPDTLSSLPALPSLEGLTVRKLQLSMDPMLDMMGMQMLMEKYGDQAMAGMDHSQMMGHMGHGNMNHMNHGGKFDFHHANKINGQAFDMNKPMFAAAKGQYERWVISGVGDMMLHPFHIHGTQFRILSENGKPPAAHRAGWKDTVKVEGNVSEVLVKFNHDAPKEHAYMAHCHLLEHEDTGMMLGFTV
What is the function of this protein?
In vitro, in the presence of excess copper ions, exhibits ferroxidase and phenoloxidase activities (PubMed:11466290, PubMed:11527384, PubMed:11867755, PubMed:15317788, PubMed:15516598, PubMed:17804014, PubMed:25679350).  Fe(2+) is an excellent substrate in the presence of excess Cu(2+), but is inactive in the absence of Cu(2+) (PubMed:15516598, PubMed:17804014).  Oxidizes the phenolate iron siderophores enterobactin, 2,3-dihydroxybenzoate (2,3-DHB) and 3-hydroxyanthranilate (3-HAA) (PubMed:11466290, PubMed:15317788).  Oxidation and thus inactivation of enterobactin could protect cells from the interaction of enterobactin with copper and play a central role as an interface between copper detoxification and iron homeostasis (PubMed:11466290, PubMed:15317788).  Also oxidizes a variety of phenolic model substrates, including 2,2'-azinobis(3-ethylbenzthiazolinesulfonic acid) (ABTS), p-phenylenediamine (pPD), 2,6-dimethoxyphenol (2,6-DMP) and 3,4-dihydroxybenzoic acid (3,4-DHB) (PubMed:11466290, PubMed:11527384, PubMed:17804014, PubMed:25679350).
What are the official names of this protein?
Multicopper oxidase CueO, MCO, Blue copper oxidase CueO, Copper efflux oxidase, Cu efflux oxidase, Cuprous oxidase.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Periplasm. Note=Exported via the Tat pathway (PubMed:10766774, PubMed:17218314, PubMed:27129241). Cytoplasmic CueO does not contain copper, even under copper stress conditions, and is transported as an apo-protein to the periplasm. Periplasmic CueO is readily activated by the addition of copper ions in vitro or under copper stress conditions in vivo (PubMed:27129241). Can also be exported by the Sec system (PubMed:17218314).
Protein: CHS7_CANGA
Sequence: MGISNFASICSRTPLPLCSVIKSTTHLVLSNSTKIHDFDPQHLNIGILPKCYARSIDIANTTIFGIGNAFINIAALGVILIILYNIRQKYTAIGRSEYLYFFQLTLLLIIFTLIVNCGVSPPGSNSFPYFVAVQIGLAGACCWTLLINGFLGFNLWEDGTTKSMLLVRGFSLCGFMANFLASILTFRTWIENHEIPNTNTTALFVVVYLWNLINLFIFVICQLFVSFFIVRNLWVTGAVLLGVFFFVAGQILTYGFSSQICEGVKHYLDGLFFGSICNIFTLMMVYKTWDITTDDDLEFSVSIDKNGDVLYN
What is the function of this protein?
Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
What are the official names of this protein?
Chitin synthase export chaperone.
What is the protein family that this protein belongs to?
Belongs to the CHS7 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AMIF_DESVH
Sequence: MGSIGSMNKPSEGMLMGLVQYPVPIVNSRRDIEASVDRICAATAATKAGYPGMDLIVWPEYSTQGLNTKKWVTEEFLMDVEEPLFQRYAQTCKENDVWGVFSIMERNPNKNQMPYNTAVIFNNKGELALKYRKLNPWVPIEPWMPGDLGQPVCDGPGGSKLSLCICHDGMFPEQAREAAYKGCNVYIRISGYSTQVNEQWILTNRSNAWHNLMYTAAVNLAGYDGVFYYFGEGQVCNFDGTTLVQGHRNPWEIVTAEVFPKMADQARTDWGLENNIFNVGTRGYVAHPGGVKDCPYTWVKDFAAGKYHLPWEDKIKIKDGSIYGYPTTGGRFGL
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: BBLN_DANRE
Sequence: MSGPNGDPDISAEGIIEDEDEFNEEEYAAIDSMLDQINSCLDDIEERNDALNGKLQELLESNRAARRDFRQQITDHADLPPPANDDDEDEQSRDAQKKD
What is the function of this protein?
Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.
What are the official names of this protein?
Bublin coiled-coil protein, UPF0184 protein C9orf16 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0184 (EST00098) family.
Protein: NEIL2_HUMAN
Sequence: MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKFQGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEPEQCQFS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles).  Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CVP4_PIMHY
Sequence: MGFLACALLVVATAHAATAIVNPETCEIGSNFKNYCNNCYCFDGVMDHALCTRESCDRNVWNEDGTRKFPKPGKWISEKENKKNDEPCTPGENFKYYCNDCQCLDGLRAHAMCTRMRCDRNVFNEDGTRKYPEPEKWNSEKERKKSDESCAPGASFKYYCNSCTCGAEGKVAEAQCTSQECDRYKWKKDGSKRPFTLDPVLHD
What is the function of this protein?
Inhibits trypsin activity and prophenoloxidase (PPO) activation, an enzyme essential for both clotting and insect innate immune responses.  It does not inhibit activity of chymotrypsin and protease K, and has no effect on phenoloxidase (PO) activity.
What are the official names of this protein?
Pacifastin-like protease inhibitor cvp4, Cysteine-rich venom protein 4.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I19 family.
What are the subcellular locations of this protein?
Secreted.
Protein: AT2B1_RAT
Sequence: MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPLIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis.  Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction.  Positively regulates bone mineralization through absorption of calcium from the intestine.  Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity).  Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity).  May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
What are the official names of this protein?
Plasma membrane calcium-transporting ATPase 1, Plasma membrane calcium ATPase isoform 1, PMCA1, Plasma membrane calcium pump isoform 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Synapse. Presynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles.
Protein: TFE_HALWD
Sequence: MAFDELLNDPVIQKYLHELVGPTGMPVAAAPPDGEVTDEELAEELGLELNDVRRALFILYENDLATYRRVRDEDSGWLTYLWTFHYENIPENLQSEMYRLLDALEERLEYERSHEFYLSEPAGIRFEFSEAMELGFQCPETGAPLEPIENQEMINAMERRIDSLQSELNVGVTQTV
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: WECG_ECOUT
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTQVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGAPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: ML12B_BOVIN
Sequence: MSSKKAKTKTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLEAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
What is the function of this protein?
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation.  Phosphorylation triggers actin polymerization in vascular smooth muscle.  Implicated in cytokinesis, receptor capping, and cell locomotion.
What are the official names of this protein?
Myosin regulatory light chain 12B, Myosin regulatory light chain 2-B, smooth muscle isoform, Myosin regulatory light chain 20 kDa, MLC20, Myosin regulatory light chain MRLC2.
Protein: C4S2B_XENTR
Sequence: MTEFLFCFSCCIGEQPQPKRRRRIDRSMIGEPMNFVHTAHVGSGDTNAGFAMGGSFQDQMKSKGGYTPGISEVAL
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
What are the official names of this protein?
CDC42 small effector protein 2-B.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Protein: FEOC_ECOLU
Sequence: MASLIQVRDLLALRGRMEAAQISQALNTPQPMINAMLQQLESMGKAVRIQEEPDGCLSGSCKSCPEGKACLREWWALR
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: PDLI5_MOUSE
Sequence: MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVSVQKGEPKEVVKPVPITSPAVSKVTSTTNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSHASPTPVAAATPLHLSASGLHVSANLSADQCSSPPNTGKPAVNVPRQPTVTSVCSESAQELAEGQRRGSQGDIKQQNGPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLTESENDNTKKANSTQEPSQQPASSGASPLSASEGPESPGSSRPSVAGLRSAAAFKPVGSTSVKSPSWQRPNQAAPSTGRISNNARSSGTGASVGPPQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
What is the function of this protein?
May play an important role in the heart development by scaffolding PKC to the Z-disk region.  May play a role in the regulation of cardiomyocyte expansion.  Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1.  Overexpression promotes the development of heart hypertrophy.  Contributes to the regulation of dendritic spine morphogenesis in neurons.  May be required to restrain postsynaptic growth of excitatory synapses.  Isoform 1, but not isoform 2, expression favors spine thinning and elongation.
What are the official names of this protein?
PDZ and LIM domain protein 5, Enigma homolog, Enigma-like PDZ and LIM domains protein.
What are the subcellular locations of this protein?
Postsynaptic density. Presynapse. Postsynapse. Cytoplasm, cytosol. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.
Protein: DNAJ_OLEA2
Sequence: MSQRDYYEVLGVSRDAADDEIKRAYRKKAMEFHPDRNPDNPEAEAKFKEAAEAYDVLRDAEKRARYDRFGHAGVNGNGYGGGGGFSSTEDIFAHFGDIFGDLFGFAGMGGARGPRPQAGSDLRYNLNISFRQAARGDEVTLRIPKNVTCPDCSGSGAAPGTQPETCPQCGGSGQVVRQQGFFQMAMPCSACRGEGRIVRNPCPRCRGAGQVQDIRELSVRIPAGVDTGNRLRLRGEGEPGVHGGPPGDLYVVIRVDDDKTFRRQGQDLVVRKEISFVQAILGDKVEVPTLDDPVTVDIPRGTQSGEVFRIAGKGLPHLGSSQTGALLVEVTVRIPSSVNDEQEKLLREFERLEENRPLRKVKNMFKKAGKAMGMD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_ZYMMO
Sequence: MQFLDQAKIYLRSGAGGPGAVSFRHEKYIEYGGPDGGNGGKGGDIVFEAVPGLNTLIDFRYTQHFRAARGASGAGSNKTGAGAKDLVIHVPVGTQVLSEDKEEILHDFTKVGERIIFLKGGDGGRGNASYKSSTNRAPRQHGPGWPAQEAWVWLRLKLLADVGLVGLPNAGKSTFLKATTNAHPKIGNYPFTTLHPQLGVVRRHGQEFVLADIPGLIEGASEGIGIGDRFLGHIERCRILLHLIDASGEDPIAAWHEVQNELALYGAGLAEKPQLLALNKIDSVDEETCAELSQALEEASGQKVLLLSGATGQGLDPILDQLITMTGRAIEKAQESSAQTEKIWSPI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_META3
Sequence: MLNKLFGRVVSGKGEGKHYMSLPPYKEKFKNILGFEPYEGTLNVKLGYIINLNELNPIEVDDFYYKNNKYYGVKLIPVRICIKDYCVNGAIVYPKKTEHPNNVIELIAPIKLRKYLSLKNNYMVKIRL
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: ERG27_CANAX
Sequence: MSLLKDSTVAVITGTSSNLGFNIAVRLLEGLPDNKEITLVVTSRTLPKVKEVISDIKKYIVEKIPTKVNKVEFDYLLVDFTDMVSILSAYYELNKRYKHIDYLFINAAQGVYGGIDWTGAVLEVLQSPIEAVTNPTYKLQKVGVESGDKLGLVFQANVFGPYYFIHRIKHLLKNGGKIVWISSLMSSPKYLSFNDLQLLRSPASYEGSKRLVDLMHFGTYNKLEREYGIKQYLVHPGIFTSFSFFQYLNVFTYYGMLFLFYLARFLGSPYHNISGYIAANAPVAAALGQTKQNCKTASACTRSGKEYLLEEEIDSTGSDDVVSYLDTLTKEWDEKLKDQIVNTRQP
What is the function of this protein?
Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.
What are the official names of this protein?
3-keto-steroid reductase ERG27.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Lipid droplet.
Protein: ECCA1_MYCLE
Sequence: MIDRLGSLFESAASMLPMSEARSFELFTEITNYDETACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQIPMTTLNARVPIGGLYGDITYPVTSPLAITMGFAACEAAQGNFADAMEAIDATSITGSEHLVAWLKAVVYGAAERWTDVIDEVKGAGKWPDKFLAGAAGVAHGVAAANLGLFTEAERRLTEANDSPAGEACARSIAWYLAMARRSQGNEDAAVALLEWLQTTHPESKVSAALKDPSYRLTTTTAEQIAARADPWDPSSVVTDNSDRDRLLTQAQAELDRQIGLTRVKTQIERYRAATMMAKVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVISEPKLVETSRKDFVAEYEGQSAVKAAKTIDLALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPDELLEIAKVIATDADSSLSAEASKNLLEAAKQLAQRTLRGRPALDVAGNGRYARQLVEAAEQCRDMRLARGVDIEQLDVDRLQEINGSDMAEAIATVHAHLNIRE
What is the function of this protein?
Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB.  EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).
What are the official names of this protein?
ESX-1 secretion system protein EccA1, ESX conserved component A1, Type VII secretion system protein EccA1, T7SS protein EccA1.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_LEPBJ
Sequence: MRQFENVTIVKKANVYYEGKVTSRTVLFQDGSKKTLGILMPGQYDFGTDEKEIMEILDGDMLVKLPGEDSWKEIKGAQSFEVPAKSRFQMDVKKISDYCCSYIG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.