PharMolix/UniProtQA huggingface dataset:
Protein: PEPM_STRHY
Sequence: MNATEQAANGDRGTTRSAGGRLRYLLHAPGACQLMGVHDGLSARIAVAEGFEALWASGLCMSTARGVRDSDEASWTELLTLVGTMTDAVPGVPVLVDGDTGYGNFNTARRFAGRAERVGAAGVCFEDKVFPKMNSFFGDGHQLAPVAEFCGKIRACKDAQRDPDFVVVARTEALISKLPMEEALDRAAAYAEAGADALFIHSRMNTPQQIATFMERWEGSTPVLIAPTTYHTPSVDDFAALGIAGCIWANHSMRAAFAAMRDVCQRIRTDRGIYGIEDQVAPLKEIFGLFDYEGLEKDENCYTQAPDLAAVQG
What is the function of this protein?
Formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr).
What are the official names of this protein?
Phosphoenolpyruvate phosphomutase, PEP mutase, PEP phosphomutase, Phosphoenolpyruvate mutase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. PEP mutase family.
Protein: HSP72_YEAST
Sequence: MSKAVGIDLGTTYSCVAHFSNDRVDIIANDQGNRTTPSFVGFTDTERLIGDAAKNQAAMNPANTVFDAKRLIGRNFNDPEVQGDMKHFPFKLIDVDGKPQIQVEFKGETKNFTPEQISSMVLGKMKETAESYLGAKVNDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKGKEEHVLIFDLGGGTFDVSLLSIEDGIFEVKATAGDTHLGGEDFDNRLVNHFIQEFKRKNKKDLSTNQRALRRLRTACERAKRTLSSSAQTSVEIDSLFEGIDFYTSITRARFEELCADLFRSTLDPVEKVLRDAKLDKSQVDEIVLVGGSTRIPKVQKLVTDYFNGKEPNRSINPDEAVAYGAAVQAAILTGDESSKTQDLLLLDVAPLSLGIETAGGVMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERAKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDVDSNGILNVSAVEKGTGKSNKITITNDKGRLSKEDIEKMVAEAEKFKEEDEKESQRIASKNQLESIAYSLKNTISEAGDKLEQADKDAVTKKAEETIAWLDSNTTATKEEFDDQLKELQEVANPIMSKLYQAGGAPEGAAPGGFPGGAPPAPEAEGPTVEEVD
What is the function of this protein?
May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.  A functional difference between SSA1 and SSA2 proteins is expected.  SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.
What are the official names of this protein?
Heat shock protein SSA2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted, cell wall.
Protein: RS6E_METBU
Sequence: MADFKIVVSDPKTKTYQFDITGAEANQFIGRSIGQTVDGATVGLDGYTLTITGGTDNSGFVMSPTLPGPRRQKVLIANGVGYSAVAKGVRRRKFLRGSEVAPDITQINTKVTGYSDKAIEEILGGGSEEVEAPAE
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: XNI_EDWI9
Sequence: MSIHLLIVDALNLIRRIHAVQGSPCGDACSAALRQLVGHTTPSHAVAVFDQDDRAESWRHRLLPGYKAGRQAMPDALAQEMESLRAAFTAQGVACWHSPGNEADDLAATLAYKVAQGGHRVTIVSTDKGYCQLLSPQIQIRDYFQKRWLDLPFVQREFGVAPQQLTDFWGLAGIGSSKIPGISGIGAKTAAALLKEFGSLEALYQHLAQVPERWRQRLTEQREMAEICRRVATLQTDLALHGNLQQLRLNGRA
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: SYE_SYNFM
Sequence: MEPVITRFPPSPTGDLHIGGARTALFNWLFARHFGGRFILRIEDTDLVRSTESSIKAILDAMEWLSLDWDEGPYYQTKRLDVYKDYLQRMVDGGAAYYCDCAPDDLERRRKSAMAEGRKPKYDGRCRDRGLGPGPDRVLRFRCPDSGTTVLNDIIKGPIFFENAELDDLVLQRSDGMPTYNFAVVVDDVTMNITHVIRGDDHVNNTPRQILIYQALGARLPYFAHVPMILGEDRARLSKRHGATSVMAYRDMGILPEALINYLVRLGWSHGDQEIFTRRELIETFSLENVGKSASVFNPEKFLWLNAHYLRERSPEALVPLLQPFLDAKGYPARSPEYVARAIPTLQPRVRTLVEMAEQMRFYLVDEVEYDPEAARKFLVSAMREPFNRLLAELAALDGFSHERLESVFQQIVSELGLKLGKVAQPVRVALTGGTVSPGLFEIIDVLGKDAVLKRLNNALRFIDRQAG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CESA2_ORYSI
Sequence: MDGAKSGKQCHVCQICGDGVGTAADGELFTACDVCGFPVCRPCYEYERKDGSQACPQCKTKYKRHKGSPPILGDESDDVDADDASDVNYPTSGNQDHKHKIAERMLTWRMNSGRNDDIVHSKYDSGEIGHPKYDSGEIPRIYIPSLTHSQISGEIPGASPDHMMSPVGNIGRRGHPFPYVNHSPNPSREFSGSLGNVAWKERVDGWKMKDKGAIPMANGTSIAPSEGRGVGDIDASTDYNMEDALLNDETRQPLSRKVPISSSRINPYRMVIVLRLIVLCIFLHYRITNPVRNAYPLWLLSVICEIWFALSWILDQFPKWSPINRETYLDRLALRYDREGEPSQLAPVDIFVSTVDPMKEPPLVTANTVLSILAVDYPVDKVSCYVSDDGAAMLTFDALAETSEFARKWVPFCKKYSIEPRAPEWYFAQKIDYLKDKVQASFVKDRRAMKREYEEFKVRVNALVAKAQKVPEEGWIMQDGTPWPGNNTRDHPGMIQVFLGHSGGLDTEGNELPRLVYVSREKRPGFQHHKKAGAMNALVRVSAVLTNGQYLLNLDCDHYINNSKALREAMCFLMDPNLGRRVCYVQFPQRFDGIDRNDRYANRNTVFFDINLRGLDGLQGPVYVGTGCVFNRTALYGYEPPIKQKRPGYFSSLCGGRKKTKKSKEKSTEKKKSHKHVDSSVPVFNLEDIEEGIEGSGFDDEKSLLMSQMSLEKRFGQSSVFVASTLMEYGGVPQSATPESLLKEAIHVISCGYEDKSDWGTEIGWIYGSVTEDILTGFKMHARGWRSIYCMPKRPAFKGSAPINLSDRLNQVLRWALGSVEILFSRHCPIWYGYGGRLKFLERFAYINTTIYPLTSIPLLLYCILPAICLLTGKFIIPEISNFASIWFISLFLSIFATGILEMRWSGVGIDEWWRNEQFWVIGGISAHLFAVFQGLLKVLAGIDTSFTVTSKASDEEGDFAELYMFKWTTLLIPPTTILIINLVGVVAGISYAINSGYQSWGPLFGKLFFAFWVIVHLYPFLKGLMGRQNRTPTIVVVWAILLASIFSLLWVRIDPFTTRVTGPDTQKCGINC
What is the function of this protein?
Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation.
What are the official names of this protein?
Probable cellulose synthase A catalytic subunit 2 [UDP-forming], OsCesA2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL20_HAEIN
Sequence: MARVKRGVIARARHKKVLKAAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGLSYSKFINGLKKASVEIDRKILADIAVFDKVAFAALVEKAKSAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SYDND_MYCA1
Sequence: MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAHRLRAEFCVAVAGLVEIRPEGNANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELRLKYRYLDLRRDAPAAAIRLRSKVNAAAREVLDRHDFVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDAEDVIAISEEILAALWALIGYEIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKNLSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARSEIAHRLGLIDPQAWAFVWVVDPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNGNEIGGGSIRIHRRDIQERVFAVMGLDNAEAREKFGFLLEAFTFGAPPHGGIAFGWDRINALLSRVDSIREVIAFPKTGGGVDPLTDAPAPITEQQRKESGIDVKPEPSKPH
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIM23_CANAW
Sequence: MSLRIILKRDFSQCIRVLESGSKSPTIANRFQAQYGNKNNNMKRNTANNGTGNGNRFHNKYNNESRRPYPKTKYQQQQQQQQQQRKPQQHQQYIIDPRKIKFDNGTESARNAIEEIFNRVNQLQRNYQIQLITDSGLKKCHLSEILQKLDLSINGLQLIDKSTTTTTTTTTTTTTTTNTSDEDLPLIKIITVRDMINQYSTYLNNLKQLELIKLGSSKTLKTLDIKLKLEQKKSTTKEILMKWSINNNDFKLQKTNEIKKLINNNGGNGKSFLINMVYNKRNTNKPINTIFKRRSNTEEDEQELIEIELKRRQLLIENLQSLLTELNCKWTIEGDINTKMTFNVTPKGQPTTIEPSTTTNIVDEEIEDYNNNNNNDDGDCDEKKMNRTERKKRKSEQQKQKQKQKQQSKTNTNSNTAKEEDLDALYSFKIED
What are the official names of this protein?
Altered inheritance of mitochondria protein 23, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NRDR_STAAW
Sequence: MKCPKCNSTQSKVVDSRHADELNAIRRRRECENCGTRFTTFEHIEVSQLIVVKKDGTREQFSREKILNGLVRSCEKRPVRYQQLEDITNKVEWQLRDEGHTEVSSRDIGEHVMNLLMHVDQVSYVRFASVYKEFKDVDQLLASMQGILSENKRSDA
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HUTI_PARXL
Sequence: MKQTVWHHLKLCPQGDPQHTLADAAIAVENGTIVWLGAACALPVEYAAWPREDLHGAWVTPGLVDCHTHLVYGGQRADEFAQRLAGVSYEEIARQGGGIVSTVRATRAADEASLLRQSAARLEPLLAEGVTTVEIKSGYGLDLASERKMLRVARQLGERYPVTVYTTFLGAHALPPEFTGRADAYIDEVCNTMLPALADEGLVDAVDVFCERIGFSLEQSERVFKAAERYQLPVKMHAEQLSNGGGTALAARHHALSADHLEFLDEAGVAAMKEAGTVAVLLPGAYYFIRETQLPPLELLRRYQVPIAISTDSNPGTSPATSLLLMMNMATTLFRMTVPEVLQGVTSHAARALGKADRHGSLEAGRAADFAVWSVDSLAELAYWIGRPLCARVVRAGETVYTRRELSQGLR
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNFB_ECOLU
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQHAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: YIDE_SHIBS
Sequence: MSDIALTVSILALVAVVGLFIGNVKFRGIGLGIGGVLFGGIIVGHFVSQAGMTLSSDMLHVIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIIGGLVTAILHKLFDIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPMEMVDQMGMSYAMAYPFGICGILFTMWMLRVIFRVNVETEAQQHESSRTNGGALIKTINIRVENPNLHDLAIKDVPILNGDKIICSRLKREETLKVPSPDTIIQLGDLLHLVGQPADLHNAQLVIGQEVDTSLSTKGTDLRVERVVVTNENVLGKRIRDLHFKERYDVVISRLNRAGVELVASGDISLQFGDILNLVGRPSAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPVFVPGFPAALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFVNTLVNGEGLSWIGYGALITAVPLITVGILARMLAKMNYLTMCGMLAGSMTDPPALAFANNLHPTSGAPALSYATVYPLVMFLRIITPQLLAVLFWSIG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TX326_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCYRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAAGKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1l, Toxin-like structure LSTX-B26.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_RUMCH
Sequence: MTKRLFTSESVTEGHPDKICDQISDAVLDAIYEKDPQARVACETAVTTGMVMVMGEITTNCYVDIPKVVRNTIREIGYDRAKYGFDCDTCAVMTSIDEQSSDIAMGVDKALEAKVGEMSEEQVQAIGAGDQGMMFGFACDETPELMPMPIILAHKLTMKLSEVRKNGKVKYLRPDGKSQVTVEYDGDKPVRVDTVVISTQHGADVSHDTIEKDIMEHVIIPVIPRELLDEGTKYFINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVASGIARKCEVQLAYAIGVAKPVSVLVDTFGTAVIPEEKISELVNKHFDLRPAAIINKLNLRRPIYRKTAAYGHFGRDDAEFSWEKTDVADALRKEAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNTB_SALTI
Sequence: MEAIKGSDVNVPDAVFAWLLDGRGGVKPLEDNDVIDSQHPCWLHLNYTHPDSARWLASTPLLPNNVRDALAGESSRPRVSRMGEGTLITLRCINGSTDERPDQLVAMRLYMDERFIVSTRQRKVLALDDVVSDLQEGTGPVDCGGWLVDVCDALTDHASEFIEELHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDHRRRMQDIADRLGRGLDEIDACIARTGIMADEIAQVMQESLARRTYTMSLMAMVFLPSTFFTGLFGVNLGGIPGGGWRFGFSLFCILLVVLIGGVTLWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPD_CERS5
Sequence: MSYSALEAAIEAAWEARDTITPATKGEARDAVEATLEALDKGSLRVAEKRGADWHVNQWAKKAVLLGFRLKDMDVQTGGPQGGTWWDKVDSKFAQWGEAQWKAAGFRAVPNCIVRRSAYIAKGVVLMPSFVNLGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPMQAGPTIIEDNCFIGARSEVVEGCIVREGSVLGMGVFIGKSTKIVDRETGEVMYGEVPAGSVVVAGSMPSKGGVNLYCAVIVKRVDAQTRSKTSINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_THEFY
Sequence: MEKFTVHTGRAVPLRYSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRTDPDFVLNKPEYKDGTILIAGPDFGTGSSREHAVWALQNYGFKAVLSSRFADIFRGNSLKGGLLTVVLPQPVIEQLWEMVEADPATEITVDLVNREVRAKDIVEPFELDDYTRWRLMEGLDDIDLTLRHVDAIAEYEKRRKPWLPVTQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: AGO1_SCHPO
Sequence: MSYKPSSEIALRPGYGGLGKQITLKANFFQIISLPNETINQYHVIVGDGSRVPRKQSQLIWNSKEVKQYFGSSWMNSVYDGRSMCWSKGDIADGTIKVNIGSESHPREIEFSIQKSSKINLHTLSQFVNSKYSSDPQVLSSIMFLDLLLKKKPSETLFGFMHSFFTGENGVSLGGGVEAWKGFYQSIRPNQGFMSVNVDISSSAFWRNDSLLQILMEYTDCSNVRDLTRFDLKRLSRKFRFLKVTCQHRNNVGTDLANRVYSIEGFSSKSASDSFFVRRLNGEEQKISVAEYFLENHNVRLQYPNLPCILVKNGAMLPIEFCFVVKGQRYTAKLNSDQTANMIRFAVQRPFERVQQIDDFVHQMDWDTDPYLTQYGMKIQKKMLEVPARVLETPSIRYGGDCIERPVSGRWNLRGKRFLDPPRAPIRSWAVMCFTSTRRLPMRGIENFLQTYVQTLTSLGINFVMKKPPVLYADIRGSVEELCITLYKKAEQVGNAPPDYLFFILDKNSPEPYGSIKRVCNTMLGVPSQCAISKHILQSKPQYCANLGMKINVKVGGINCSLIPKSNPLGNVPTLILGGDVYHPGVGATGVSIASIVASVDLNGCKYTAVSRSQPRHQEVIEGMKDIVVYLLQGFRAMTKQQPQRIIYFRDGTSEGQFLSVINDELSQIKEACHSLSPKYNPKILVCTTQKRHHARFFIKNKSDGDRNGNPLPGTIIEKHVTHPYQYDFYLISHPSLQGVSVPVHYTVLHDEIQMPPDQFQTLCYNLCYVYARATSAVSLVPPVYYAHLVSNLARYQDVTADDTFVETSEASMDQEVKPLLALSSKLKTKMWYM
What is the function of this protein?
Required for G1 arrest and mating in response to nitrogen starvation.  Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1.  Required, indirectly, for regulated hyperphosphorylation of cdc2.  Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis.  Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus.  Promotes histone H3K9 methylation necessary for centromere function.  Required for recruitment of swi6 and cohesin to an ectopic dg repeat.  A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.  Has ribonuclease H-like cleavage (slicing) activity towards target messages complementary to siRNA and can direct site-specific cleavage of RNA substrates via siRNA.  Slicing activity is required for both post-transcriptional and transcriptional gene silencing as well as for histone H3 'Lys-10' methylation spreading, conversion of double-stranded siRNA to single-stranded siRNA and siRNA-dependent association of ago1 with chromatin.  A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation.  The ARC complex contains mostly double-stranded siRNA.
What are the official names of this protein?
Protein argonaute, Cell cycle control protein ago1, Eukaryotic translation initiation factor 2C 2-like protein ago1, PAZ Piwi domain protein ago1, Protein slicer, RNA interference pathway protein ago1.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Associates with telomeric and mating-type region heterochromatin.
Protein: ENGB_BORPE
Sequence: MSLLHRASFYISAARLDQLPPAGAPEVCFVGRSNAGKSSAINVLCNQRRLAFSSKTPGRTRLINMFGLPDPLAPGEQLGFLVDLPGYGYASVAHREKEKWADILGGYLRDRASLAGIVLLIDIRRGVTDLDRRLTNFIAPTGRPVLALLTKADKLPYGQRMRTVFAVRKDLADIGALHMVPFSSTERIGLEEAGAHIENWISPKVVP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: INSA_SALTI
Sequence: MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSGRSR
What is the function of this protein?
Absolutely required for transposition of IS1.
What are the official names of this protein?
Insertion element IS1 protein InsA.
What is the protein family that this protein belongs to?
Belongs to the IS1 elements InsA family.
Protein: SYC_CLOBM
Sequence: MKVYNTLTNKKEEFVTLVPGEVKMYVCGPTVYNFFHIGNARTFVVFDTIRRYLEYRGYKVKFIQNFTDIDDKMIKRANEEGSTVKELGDRFIKEYYKDADDLNIERATKNPRATEFMEEIIKFVSDLIEKGYAYEIDGDVYFSTKKFNSYGKLSGQNLEELQLGSRINVDERKKDPMDFAIWKNQKPGEPAWESPWGMGRPGWHIECSCMAYNLLGETIDIHAGGSDLSFPHHENEIAQSEARTGKQFAKYWLHSAFVNVNNQKMSKSLNNFFTAREILEKYDADVLRMFMLSGHYRTQINFSMELLDSTKAALDRLYNSINNLENLLDEVKNEELRDEELEYKNELQKYKEKYIEKMDDDFNTADAISVIFDLIRDVNTNVTIESSKELVKYTLDLIRELGNPLGILQESTKASLEEEIEKLIEERQKARKEKNWALADKIRDDLKERGIVLEDTPQGVRWKQI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RARR2_BOVIN
Sequence: MWQLLLPLALGLGTMGLGRAELTTAQHRGLQVALEEFHKHPPVLWAFQVTSVDNAADTLFPAGQFVRLEFKLQQTSCRKKDWRKEDCKVKPNGRKRKCLACIKLDSKDQVLGRMVHCPIQTQVQRELDDAQDAQCSRVERAGEDPHSYYLPGQFAFIKALSP
What is the function of this protein?
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1).  Acts also as a ligand for CMKLR2.  Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2.  Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue.  Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues.  Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases.  Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells.  Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells.  The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production.  Exhibits an antimicrobial function in the skin (By similarity).
What are the official names of this protein?
Retinoic acid receptor responder protein 2, Chemerin.
What are the subcellular locations of this protein?
Secreted.
Protein: CD2_MACFA
Sequence: MSFPCKFVASFLLIFNVSSKGAVSKEIRNALETWGALGQDIDLDIPSFQMSDDIDDIRWEKTSDKKKIAQFRKEKETFEEKDAYKLFKNGTLKIKHLKIHDQDSYKVSIYDTKGKNVLEKTFDLKIQERVSEPKISWTCINTTLTCEVMNGTDPELNLYQDGKHVKLSQRVITHKWTTSLSAKFKCTAGNKVSKESRMETVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELEIRAHRVATEERGRKPHQIPASTPQNPAASQHPPPPPGHRSQAPSHRPLPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPQGAAENSLSPSSN
What is the function of this protein?
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types.  CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function (By similarity).
What are the official names of this protein?
T-cell surface antigen CD2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CAPSD_HBVD3
Sequence: MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGVNLEDPASRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.