PharMolix/UniProtQA huggingface dataset:
Protein: MNMA_SYNP2
Sequence: MGKVAVGLSGGVDSSVTAGILHRQGYTVEGVTLWLMKGKGQCCSEGMVDAADICEQLGIPHHIVDSRDLFQKYIVDYVVSGYEVGVTPLPCSQCNRMVKFGPMLQWAKAELGIDQIATGHYARIRYNDQTGRYELLRAVDRHKDQSYFLYDLTQEMLAGTLFPLGEMTKGETRQIAAEMQLSTAKKPESQDLCLIEAHGSMKTFLDKYIEQREGEIVDLDGKVLGHHTGIHHYTIGQRKGLGIAAPEPLYVVKLDNVMNRVVVSTRDRAGQSECTVQRMNWLALPGITSPIRAEVQVRYRSGAVPVTVIPLEGDRLKLVFEEPQFGITPGQAAVLYDGDRVLGGGIIEHPEAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPCS_CAEBR
Sequence: MKSSFGKKEGEYSRLVSKSSNKLLNSLWEKKQIPEEGWTEHTLDLFLSWLSSHDTNNRVDMIPVGAGEREGRVLTPLVQRLHSNLTHGIGRSGNLLEIQPKALGSSMLACLSNEFAKHALHLLGLQTVKSCIVVPLCTGMSLSLCMTSWRRRRPKAKYVIWLRIDQKSSLKSIYHAGFEAIIVEPTRDHDALVTDVETVNRIVEQRGEELLCVMTTTSCFAPRSPDNIEAISAICAAHDVPHLVNNAYGLQSEETIRKIAAAHECGRVDAVVQSLDKNFQVPVGGALIAGFKQSHIQSIAQAYPGRASSVPSRDLVLTFLYQGQSAFLEPFQKQKQMFLKMRRKLTSFAENVGECVYDVPENEISLAMTLSTIPPTKQTLFGSVLFSRGITGARVVQSSQSKTTIEGCEFVNFGSHTAEQHGGYLNIACSIGMADHELEELFTRLTSSYAKFIRQLAKEDDRRGGSSGRRVPMNESFDMEND
What is the function of this protein?
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
O-phosphoseryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, UGA suppressor tRNA-associated protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SepSecS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1A_NOCFA
Sequence: MTAVEPRPVPQLEATRPYPARTGPKGSFLYKMVTTTDPKVLGTMYLVTAMSFFMIGGLMALLMRGELARPGLQFLSPEQFNQLFTMHGTIMLLFYATAIVFGFANIILPLQIGAPDVAFPRLNAFSYWLYAFGATMATAGFITPGGAADFGWTAYVPLTDILHSPGVGTDLWILGLAVSGLGTILGGVNMLTTVVCLRAPGMTMFRMPIFTWNIAVTSVLVLLAFPLLTAALFGLAYDRHLGGHIYDPATGGILLYQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLGIAALSIAVWAHHMYATGAVLLPYFSFMTFLIAVPTGVKFFNWIGTMWRGQLTFESPMLWSLGFLVTFLFGGLSGVILASPPLDFHVTDSYFVVAHFHYVLFGTIVFATFAGIYFWFPKITGRMVDERLAKWHFWATFVGFHTTFLVQHWLGAEGMPRRYADYLPSDGFTTLNTISTIGAFVLGASMLPFIWNIFKSYRYGEVVTVDDPWGYGNSLEWATTCPPPRHNFYELPRIRSERPAFELHYPHMIERMRAEAHVGWGSGKHGTPQDDDALLAKK
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1-alpha, Cytochrome aa3 subunit 1-alpha, Cytochrome c oxidase polypeptide I-alpha.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SEPF_MYCSK
Sequence: MSTLHKVKAYFGMAPMDDYDDEYYEDDDRAERGAARGYARRPREDRFEEEGYIDRAGREYDDRPAPREYDEPPIYRGGYDEPRFDPRLRGPREFERPAPRLGALRGSTRGALAMDPRRMAMLFEEGSPLAKITTLRPKDYSEARTIGEKFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVTADERRRIAEAGFYAYQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: QUTD_ASPFN
Sequence: MSILSLVEDRPTPKEVYNWKIYLLAAVASCTSCMIGYDSAFIGTTISLQSFKDEFDWDSMSAAHQDLVSSNIVSLYQAGAFFGAFFAYPIGHFWGRKWGLMVSALIFTLGAGIMLGTNGDRGFGLLYGGRVLAGLGVGAGSNITPIYISELSPPAIRGRLVGVYELGWQIGGLVGFWICYGVDETLPPSHKQWIIPFAVQLIPSGLLIIGALFLKESPRWLFLRGRREEAIKNLCWIRQLPEDHVYMIEEIGAIDQTLEHQRATIGLGFWKPFAAAWTNKKILYRLFLGSMLFFWQNGSGINAINYYSPTVFKSIGVTGSNTSLFTTGIFGVVKTVVTFIWLLWLIDRVGRRLLLLIGAAGGSICLWIVGAYIKIARPSERENKQMDGGGIAAMFFFYLWTVFYTPSWNGTPWVINSEMFDPNIRSLAQACAAGSNWLWNFLISRFTPQMFAKMDYGVYFFFASLMILSIIFVFFLIPETKGIPLESMDRLFETQPIWRAHGTLLKQIREDEERFRHDLEDSGFVKSTDRQVEVVDA
What is the function of this protein?
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
What are the official names of this protein?
Probable quinate permease, Quinate transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane.
Protein: PYRD_MARN8
Sequence: MYGLLRNLLFRLPPERAHNVALGSLDVAQKLGILNTFTRQPEPCPVNVMGLEFPNPVGLAAGLDKNADHIDALGALGFGFIEVGTVTPLAQPGNPKPRMFRLPEHQAIINRMGFNNEGLEHLITNVRHRRYRGVLGINVGKNKDTPNEQSEQDYRKGIAAVYPYADYITVNVSSPNTPGLRDLQFGDSLKQLLHAIKEEQAACEQKHGRYVPVAVKIAPDMDEQGIRFVAAALLEAGLDGVIATNTTISREAVKGHVHEQEAGGLSGAPVREASVKVIQGLYAELGDRLPIIGVGGITDGDSAAEKIRAGAKLVQIYTGFIYRGPSLINEAVEAIRKEIS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DAPD_RUEPO
Sequence: MSNQELEAAIEAAWDARDSITPATTGATREAIEETLAALDGGGLRVAEKQADGSWHVNQWAKKAVLLGFRIKDMEIQSGGPQGGGWWDKVDSKFAGWGESQWKAAGFRAVPNCVVRKSAYIAPGVVLMPSFVNLGAYVDSGTMVDTWATVGSCAQIGRNVHLSGGVGIGGVLEPMQAGPTIIEDNCFIGARSEVVEGVIVREGAVLGMGVYIGQSTKIVDRETGEVMYGEVPPYSVVVSGSMPSTGGVSLYCAVIVKRVDERTRSKTGINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YWBF_BACSU
Sequence: MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGSQVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFILIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLYPIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTFAPNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLSGGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMYAAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQPAVTFKP
What are the official names of this protein?
Uncharacterized transporter YwbF.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL4_HELPJ
Sequence: MSKAIVLDSHLKEKGSVELPKRYEGINSHNLYLYVKHYLSSARANTAKSKNRAEVSGGGRKPWAQKGGGRARAGSITSPVFVGGGVSHGATNKRNYNLKINKKQKRLALEYALEEKAQANKLFVVEKIAIKGVVEDNKRKHLTKEANQMFQALEQRDTLFVCLNMDEYTELAFSNLKKCLVIDVSELNAYLLAAFSSVVMEEAAFQHVVQDKTEE
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NOS1_RAT
Sequence: MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVILNNPYSEKEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.  In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.  Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.  Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.  Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
What are the official names of this protein?
Nitric oxide synthase, brain, BNOS, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines.
Protein: FAL1_DEBHA
Sequence: MDDFDRDVDNELEFSAKSTKNIKVHATFESMNLKTDLLKGIYGYGFEAPSAIQSRAIMQIISGKDTIAQAQSGTGKTATFSIGMLEVIDTKSKDCQALILSPTRELAQQIQSVVKHLGDYMNVHTHACIGGTHVGEDIKKLQQGQQIVSGTPGRVVDMIKRRNLATRNIKMMILDEADELMTKGFKEQIYEIYRYLPPGVQVVVVSATLSREVLEVTGKFTTDPVKILVKRDDITLEGIKQYHIQCEKEDWKFDTLCDLYDSLTITQAVIFCNTKVKVNWLTDQMKKANFTVVAMHGDMKQDERDSIMNDFRTGNSRVLISTDVWARGIDVQQVSLVINYDLPTDKENYVHRIGRSGRFGRKGVAINLVTKEDVDELRDIERFYRIRIKEMPVNVNDIM
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase FAL1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: COAD_VIBC3
Sequence: MSQKRLSRVIYPGTFDPITNGHLDLIERAAQMFDEVIIAVAASPSKNTLFTLEERVEFARQVTSHLDNVSAKGFSGLLVDFAKAEKANVLIRGLRTTVDFEYEFGLTNMYRRLMPGLESVFLTPAEEHAFISSTLVREVAIHGGNVDEFVPAIVANALHQKKKI
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K1143_RAT
Sequence: MSKRNQVSYVRPAEPAFLSRFKERVGYREGPTVETKKIQPQLPDEDGNESDKEDEQPQVVVLKKGDLTAEEVMKIKAEIKAAKADEEPPPADGRIMYRKPVKRSSDEKCSGLTASSKKKKTNEDDVNKQSPVRKNSQKQIKNSSLLSFGSEDENE
What are the official names of this protein?
Uncharacterized protein KIAA1143 homolog.
Protein: FLGH_SALTY
Sequence: MQKYALHAYPVMALMVATLTGCAWIPAKPLVQGATTAQPIPGPVPVANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTSFGFDTVPRYLQGLFGNSRADMEASGGNSFNGKGGANASNTFSGTLTVTVDQVLANGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNSVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSPM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: HBEAG_HPBDW
Sequence: MWNLRITPLSFGAACQGIFTSTLLLSALTVPLVCTIVYDSCLYMDINASRALANVYDLPDDFFPKIDDLVRDAKDALEPYWKSDSIKKHVLIATHFVDLIEDFWQTTQGMHEIAESLRAVIPPTTAPVPTGYLIQHEEAEEIPLGDLFKHQEERIVSFQPDYPITARIHAHLKAYAKINEESLDRARRLLWWHYNCLLWGEANVTNYISRLRTWLSTPEKYRGRDAPTIEAITRPIQVAQGGRKTSSGTRKPRGLEPRRRKVKTTFVYGRRRSKSRERRAPSPQRAGSPLPRSSSSHHRSPSPRK
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein.
What is the protein family that this protein belongs to?
Belongs to the avihepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted.
Protein: PNP_SINFN
Sequence: MFETHKVEIEWAGRPLKLETGKIARQADGAVLATYGETVVLATVVSAKAPKPGQDFFPLTVNYQEKTYAAGKIPGGYFKREGRPSENETLVSRLIDRPIRPLFPDGYKNDTQVIVTVMQHDLENNPDVVSMVAASAALTLSGIPFMGPIGGARVGYINGEYVLNPHLDEMDESSLDLVVAGTQEAVLMVESEAKELPEDVMLGAVVFGQQGFQPVIDAIIKLAEVAAKEPREFDPEDHSALENAMLAIAEDELRNAYKITEKAARYAAVDAVKAKVKEHFLPEGIENPAHTAEEIGSVFKHLQAKIVRWNILDTKSRIDGRDLETVRPIVSEVGLLPRTHGSALFTRGETQAIVVATLGTGEDEQYVDSLTGMYKERFMLHYNFPPFSVGETGRMGSPGRREIGHGKLAWRAIRPMLPEAEQFPYTLRVVSEITESNGSSSMATVCGTSLALMDAGVPLAKPVAGIAMGLIKEDERFAVLSDILGDEDHLGDMDFKVAGTEAGITSLQMDIKIEGITEEIMGIALNQAKGGRLHILGEMAKAISESRGQLGEFAPRIEVMNIPVDKIREVIGSGGKVIREIVEKTGAKINIEDDGTVKIASSSGKEIEAARKWIHSIVAEPEVGQIYEGTVVKTADFGAFVNFFGARDGLVHISQLASERVAKTTDVVKEGDKVWVKLMGFDERGKVRLSMKVVDQATGKEVVAEKGEKKDGGEAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3A_CHLTR
Sequence: MTWIPLHCHSQYSILDATCSIKKFVAKAVEYQIPALALTDHGNLFGAVEFYKTCKQNAIKPIIGCELYVAPSSRFDKKKERKSRVANHLILLCKDEEGYRNLCLLSSLAYTEGFYYVPRIDRDLLSQHSKGLICLSACLSGSVAQAALESEEDLEKDLLWYQDLFQEDFFSEVQLHKSSEEKVALFEETWLKQNYYQFIEKQLKVNEAVLATSKRLGIPSVATNDIHYLNPDDWLAHEILLNVQSREPIRTAKQNTYIPNPKRKTYPSREFYFKSPQEIAELFAAHPETITNTCIVAERCHLELDFETKHYPIYVPEALQKKGSYTEEERYKASSAFLEELCEQGLTSKYTPELLGHIAKKFPGEDPLTLVKERLKLESSIIISKGMCDYLLIVWDIINWAKDHGIPVGPGRGSGAGSVMLFLLGITEIEPIRFDLFFERFINPERISYPDIDIDICMIGRERVINYAIERHGKDNVAQIITFGTMKAKMAIKDVGRTLDTPLAKVNFIAKHIPDLNATITSALEADPELRQLYVDDAEAAEVIDMAKKLEGSIRNTGVHAAGVIICGDPLTNHIPICVPKDSSMISTQYSMKPVESVGMLKVDFLGLKTLTGIHIATQAIYKKTGILLRAATIPLDDQNTFSLLHQGKTMGIFQMESRGMQDLAKNLRPDAFEEIIAIGALYRPGPMDMIPSFINRKHGKENIEYDHPLMEPILKETFGIMVYQEQVMQIAGSLAKYSLGEGDVLRRAMGKKDHEQMVKEREKFCSRAAANGIDPSIATTIFDKMEKFASYGFNKSHAAAYGLITYTTAYLKANYPKEWLAALLTCDYDDIEKVGKLIQEAHSMNILVLPPDINESGQDFEATQKGIRFSLGAVKGVGMSIVDSIVEEREKNGPYKSLQDFVQRADFKKVTKKQLENLVDAGTFDCFEPNKDLALAILNDLYDTFSREKKEAATGVLTFFSLDSMARDPVKITVSPENVIQRSPKELLKREKELLGVYLTAHPMDAVEHMLPFLSVVPARDFEGLPHGTIIRTVFLIDKVTTKISSAEQKKFALLQVSDEVDSYELPIWADMYAEYRDLLEEDRLIYAILAIDRRSDSLRLSCRWMRDLSTVNDSVIAECDEVYDRLKSQKVYSSTKKSTGAQSSAMIKKVETREISPVTISLDLNKLRHSHLFILKGLIRKYSGSQALSLVFTKDNQRFASISPDADFFVTDDISSLLQEIEATNIPARVLATTV
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DICER_CRIGR
Sequence: MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPRAKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWSQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCESCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYASQPCEIVVDCGPFTDRSGLYERLLMELEEAINFINDCNVSVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTLLRKIHALCEEHFSPASLDLKYVTPKVMKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIQSFEEDLKTYKAIEKILRNKCSKSVDGAEADVDAVVDDDDVFPPYVLRPDDGGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTQELPDGTFYSTLYLPINSPLRASIVGPPMGCVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPALEFKPTGAESAYCVLPLNVVNDSSTLDIDFTFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPNLDFGWKKSIDSKSFISTCNSSLAENDNYCKHSTIIVPENAAHQGATRTPLENHDQMSVNCRRLPAESSGKLQIEVSTDLTAINGLSYNKNLANGSYDLVNRDFCQGNQLNYFKQEIPVQPTTSYPIQNLYHYENQPKPSNECTLLSNKYLDGNANTSTSDGSPAVSTMPAVMSAGRALKDRMDSEQSPSAGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNAEKWEKDEMTKDCLLANGKLGKDCEEEEALTWRAPKEEAEYEDDFLEYDQEHIQFIDSMLMGSGAFVKKISLSPFSTSDSAYEWKMPKKSSLGSMPFSSDLEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTSREKALYPAQENFSSQQKSLSGSCAATAASPRSSAGKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS
What is the function of this protein?
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing.  Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs.  SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation.  Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance.  The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
What are the official names of this protein?
Endoribonuclease Dicer.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASRP_LOTGI
Sequence: MTSYDEEAAINPKAVGNKSSLLKYIIGGGVLAVVGVVAVMVSLQVSGNLVKSEANTLAAQSSGAQRGDRLDLDNDDDLEDEIKEIDDKFKKEFDTLLDNVIQEVNKQLKADLNGGATAGGVNNGGDTDESSNDTDEDSNDSDSKDTDSDSKDTDSDSKDSDSNDTDSDSNGSDSKDTDSDSKDSDSKDTDSDSKDTDSDSKDSDSKDTDSDSKDTDSDSKDSDSNDTDSD
What are the official names of this protein?
Aspartate and serine-rich protein, Uncharacterized shell protein 23, LUSP-23.
What are the subcellular locations of this protein?
Secreted.
Protein: VP30_EBORR
Sequence: MEHSRERGRSSNMRHNSREPYENPSRSRSLSRDPNQVDRRQPRSASQIRVPNLFHRKKTDALIVPPAPKDICPTLKKGFLCDSKFCKKDHQLDSLNDHELLLLIARRTCGIIESNSQITSPKDMRLANPTAEDFSQGNSPKLTLAVLLQIAEHWATRDLRQIEDSKLRALLTLCAVLTRKFSKSQLGLLCETHLRHEGLGQDQADSVLEVYQRLHSDKGGNFEAALWQQWDRQSLIMFISAFLNIALQIPCESSSVVVSGLATLYPAQDNSTPSEATNDTTWSSTVE
What is the function of this protein?
Multifunctional protein that acts as a viral transcriptional activator.  Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription.  Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA.  Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures.  Assists also stop-start transcription at gene junctions to promote transcription of downstream genes.  Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (By similarity).  Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis.  Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP (By similarity).
What are the official names of this protein?
Transcriptional activator VP30, EbolaVP30, eVP30, Minor nucleoprotein VP30.
What is the protein family that this protein belongs to?
Belongs to the filoviridae transcriptional activator VP30 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Present in viral inclusion bodies due to its interaction with NP.
Protein: NRAM_I03A0
Sequence: MNPNQKITTIGSICMVIGIVSLMLQIGNIISIWVSHSIQTGNQHQAEPCNQSIITYENNTWVNQTYVNISNTNFLTEKAVASVTLAGNSSLCPISGWAVYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNIMRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKVVKSAELNAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYRIGYICSGVFGDNPRPNDGTGSCGPVSPKGAYGIKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTGTDSNFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.