PharMolix/UniProtQA huggingface dataset:
Protein: CTB6_CERBT
Sequence: MADSLVLLTGATGFIGFRILIELLRQGYSVRAVIRSAGKGQWLESRLTAVMKGSDYKDRFETTTVADFVTDGAFDQAAENTSYIIHVASPIVSSDNPDDWEHDFKRVAVKGSIGVLEAAKRSGTVRRVVITSSMVGLFSPKALFAEPSEVPLNAESRIPEMEPPYAHKMLAYQAGKIASINSAEAWIKNEKPAFDLVHMHPSFVTGRDDLATTREDLRKFSSNWHSMQIVLGHKNPIGKPILTCHNDDVARCHVLALDPKVTGNQSFLISCSPEDGSEWDDVKKFVQREFPEAVAQGVLPNDGHMPTVNKGVRFDVRKTEETFGFKHIPYEAQVLDVVKQYLELPEKDEGVEISTTA
What is the function of this protein?
Ketoreductase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (By similarity).  The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).  These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).  The first step of cercosporin biosynthesis is performed by the polyketide synthase CTB1 which catalyzes the formation of nor-toralactone (By similarity).  The starter unit acyltransferase (SAT) domain of CTB1 initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain.  The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity).  The bifunctional enzyme CTB3 then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening (By similarity).  The O-methyltransferase CTB2 further methylates the nascent OH-6 of the CBT3 product, blocking further oxidation at this site before the reductase CTB6 reduces the 2-oxopropyl ketone at position C7, giving naphthalene (By similarity).  The FAD-dependent monooxygenase CTB5 in concert with the multicopper oxidase CTB12 are responsible for homodimerization of naphthalene with CTB7 installing the dioxepine moiety, finally producing cercosporin (By similarity).  The fasciclin domain-containing protein CTB11 might act with CTB5 and CTB12 whereas the roles of CTB9 and CTB10 have still to be elucidated (By similarity).
What are the official names of this protein?
Ketoreductase CTB6, Cercosporin toxin biosynthesis cluster protein 6.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: BAB2_DROME
Sequence: MDMTKQIVDFEIKSELIGEIDQFEASDYTMAPPEEPKMVEESPQLGHLEDQNRKYSPEREVEPTLQDPSEVVDQMQKDTESVGEVKSPEKDVETELVKSKASPMNDQALTPPPRPLTSSEVVGLRDPEHTELRMCLEAKKSRSLPVSPQPQPNLKLAGSALFEFGQRSSPVETKIKTNPETKPPRRKIVPPSGEGQQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAAMHSPPGGVAVQSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIREEERAKMIESGGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLKSWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSLDGGADPRPKARGRPQRILLGMWPEELIRSVIKAVVFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNGYHSAAAAKLAAQNAALAPPDAGSPLSSMTETLRRQILSQQQQHQQHHQQQAHHQQQPSHHQQQSPHAQSMNMYKSPAYLQRSEIEDQVSAAAAVAAAAAKHQQQQGERRGSENLPDLSALGLMGLPGLNVMPSRGSGGGSGGAAPNSAASYARELSRERERDRERERERELSRQYGSQSRGSSSGSGSAKSLTASQRPGAASPYSAAHYAKHQASAYNKRFLESLPAGIDLEAFANGLLQKSVNKSPRFEDFFPGPGQDMSELFANPDASAAAAAAAYAPPGAIRESPLMKIKLEQQHATELPHED
What is the function of this protein?
Probably acts as a transcriptional regulator.  Required for the specification of the tarsal segment.  Also involved in antenna development.
What are the official names of this protein?
Protein bric-a-brac 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGX_ECODH
Sequence: MTQLAIGKPAPLGAHYDGQGVNFTLFSAHAERVELCVFDANGQEHRYDLPGHSGDIWHGYLPDARPGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVMGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPGGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEANGEENRDGTNNNYSNNHGKEGLGGSLDLVERRRDSIHALLTTLLLSQGTPMLLAGDEHGHSQHGNNNAYCQDNQLTWLDWSQASSGLTAFTAALIHLRKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEVTEIVLPAGEWHAIPPFAGEDNPVITAVWQGPAHGLCVFQR
What is the function of this protein?
Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
What are the official names of this protein?
Glycogen debranching enzyme, Limit dextrin alpha-1,6-maltotetraose-hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: SYH_EXISA
Sequence: MMKAPRGTQDLLPGTVETWQYVEEKLRDMSARYNYKEIRTPIFETTNLFTRSVGETTDIVQKEMFTLVKKGKDEYTLRPEGTASVVRAFVTNKLFGNPDQPTKLYYMGPMFRYERPQKGRFRQLHQYGVEAIGSSDPAVDAEVISLAYSIYKSFGLQKIKVVVNSLGDAESRNAHRDALIRHFEPVAGELCQDCQSRLYKNPLRILDCKVDRDHPSMKTAPSILEYLNEESKAYFEQVLAQLDALGVAYEVDPTLVRGLDYYTHTAFEIMSEAEGFGAITTLCGGGRYNGLVQDIGGPDMPGIGFGIGLERLILALENEGVLPELETGLDVFIVAQGEKEVELTATRLLQLLRMEGFKADRDYQGRKFKGQFKQADRLKAKFTVILGDDEVERGAAALKDMTTGEQVDVPLSAVADKIRELSEGAGQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP_TULV
Sequence: MFCLCLSLLGLLLCWPAATRNLLELKVECPHTIGLGQGIVIGSAELPPVPLAKVESLKLESSCNFDLHTSTAAQQAFTKWSWEKKADTAENAKAASTTFQSSSKEVQLRGLCVIPTLVLETASRTRKTVTCFDLSCNQTVCQPTVYLMAPIQTCVTTKSCLLGLGDQRIQVVYEKTYCVSGQLIEGNCFNPLHTIAISQPTHTYDIMTLAVHCFFISKKGGTDDTLKIEKQFETLVEKTGCTENALKGYYACILGTSSEVVYVPAMDDYRSSEILSRMTTAPHGEDHDIDPNAISSLRIVGQLTGKAPSTESSDTVQGIAFAGTPLYTSTSILVRKEDPIYLWSPGIIPEGNHSQCDKKTLPLTWTGFITLPGEIEKTTQCTVFCTLSGPGADCEAYSDTGIFNISSPTCLVNRVQRFRGAEQQVKFVCQRVDLDITVYCNGVKKVILTKTLVIGQCIYTFTSIFSLMPGVAHSLAVELCVPGLHGWATISLLITFCFGWLAIPLLSMIIIRFLLIFTYLCSKYSTDSKFKLIIEKVKQEYQKTMGSMVCEVCQQGCETAKELESHKKSCPHGQCPYCLNPTEATESALQAHFKVCKLTTRFQENLKKSLSTYEPKRGLYRTLSMFRYKSKCYVGLVWCILLTMELIVWAASAETINLEPGWTDTAHGSGIIPLKTDLELDFSLPSSATYTYRRELQNPANEQEKIPFHFQMERQVIHAEIQHLGHWMDGTFNLKTAFHCYGSCIKYAYPWQTAKCFLEKDFEFETGWGCNPPDCPGVGTGCTACGVYLDKLRSVGKVYKILSLKYTRKVCIQLGTEQTCKTIDSNDCLVTTSVKVCMIGTISKFQPGDTLLFLGPLEEGGMIFKQWCTTTCQFGDPGDIMSTPLGMKCPEHAGSFRKKCSFATLPSCQYDGNTVSGYQRMIATKDSFQSFNITEPHITTNSLEWVDPDSSLKDHVNLIVNRDLSFQDLAENPCQVDLSVSSIDGAWGSGVGFNLVCSVSLTECASFLTSIKACDSAMCYGSSTANLVRGQNTVHVVGKGGHSGSKFMCCHDKKCSATGLVAAAPHLDRVTGYNQIDTNKVFDDGAPQCGVHCWFKKSGEWLLGILSGNWMVVAVLIALFIFSLLLFSLCCPRRQNYKKNK
What is the function of this protein?
Forms homotetramers with glycoprotein N at the surface of the virion.  Attaches the virion to host cell receptors including integrin ITGAV/ITGB3.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.  Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion.
What are the official names of this protein?
Envelopment polyprotein, Glycoprotein precursor, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the hantavirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Multi-pass membrane protein. Host cell surface. Host Golgi apparatus membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host mitochondrion. Note=Interaction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host cell surface. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=Budding probably takes place at the host Golgi (Probable). Glycoprotein C cytoplasmic tail is important for efficient Golgi localization (By similarity).
Protein: NU2C2_ACOAM
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTSLVMSIAALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDSITIFVAPECFSLCSYLLSGYTKRDVRSNEATMKYLLMGGASSSILVHGFSWLYGLSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RSMH1_LACP7
Sequence: MADQNINKNEKVLTGQPTENQEPVHKRRERYKGTHPKTFKEKYKERQPEKYADTIEKVIQKGSTPAGMHISICVNEILEFLQIKPGQKGLDATLGYGGHTREMLKCLESQGHMYALDVDPIEIVKTRERLQNLGFGPEILTIKQLNFANIDEVVEEAGLFDFVLADLGVSSMQIDDPDRGFSFKTDGPLDLRLNPEKGISAAERLKTISQTELQGMLLENSDEPYSEEISKAIVNEIKRGNEIDTTTKLRDLISKVLVTIPENEQKEAIKKTCQRTFQALRIDVNNEYEVLYSFLEKLPNVLAKGGRVAILTFHSGEDRLVKKSFKNLQRAGIYSEVSDDVIRPSAEECNRNPRARSTKMRWAIKA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H 1, 16S rRNA m(4)C1402 methyltransferase 1, rRNA (cytosine-N(4)-)-methyltransferase RsmH 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS27A_LUPAL
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGAKKRKKKTYTKPKKIKHKHKKVKLAVLQFYKVDDSGKVQRLRKECPNTECGAGTFMANHFDRHYCGKCGKTYVYQKADA
What is the function of this protein?
Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.
Protein: NUOK_BARGA
Sequence: MYIDITHYLTVSALMFTIGIAGIFLNRKNVIIILMSIELILLSVNLNFVAFSAFLHDLVGQIFALFVLTVAAAEAAIGLAILVVFFRNRGSIAVEDVNVMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_COXBU
Sequence: MARINQLVRKPRRARAKKSDVPALEGCPQRRGVCTRVYTTTPKKPNSALRKVARVRITNGAEVTAYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGSLDTAGVSGRRRGRSKYGEKKPKE
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PLH14_FORAG
Sequence: MKTRYFLLLGICMLSCRTDEKKQVQKEVDKPNVLFIAVDDLNNMISPIANFSNIQTPNFDRLAAMGVTFTDAHCPAPLCGPSRSAIMTGLRPSTTGIYGMTPDNKIRRDDNEATKDIIFLPEYFKKNGYHSMGIGKLFHNYAPDGMFDEGGGRVKGFGPFPEKRFVWDGFGTSKSRKGQYGRTNTDWGAFPESDTLMPDHQAVNWVLERFNKNYKQPFFLALGFQRPHVPLYVPQKWFDLYPLESIQTPPYQSDDLNDIPPVGLKINDLPMMPSTEWAINSGEWKKIIQAYLACVSFVDYELGRVLDALKNSPYAKNTIIVLWSDHGYRLGEKGTFAKHALWESATKAPLFFAGPNLPKGKKIDAPVEMLSIYPTLLELSGLQAYARNEAKSLVRMMQKNEGLKDTYAITTYGKNNHAVKVDGYRYIQYEDGTEEFYDNASDPNEWINEANNFKFKSKIEALKALLPKTNATWDAESNYTFQPYFVEQKTRGNVNAAKAVKVIGAER
What is the function of this protein?
Sulfatase that may be involved in ulvan degradation (PubMed:31285597).  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable).  Has no activity on different ulvan polymers (PubMed:31285597).
What are the official names of this protein?
Sulfatase, Arylsulfatase, Polysaccharide utilization locus H protein P14, PUL H protein P14, Sulfatase family S1 subfamily 7 protein P14, P14_S1_7.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PDXB_SHEB2
Sequence: MKILVDENMPYVEPLFGDLGDIIPVNGRTLTAEQVREADVLLVRSVTKVNAELLSGNNKLKFVGSATIGTDHVDLAYLAERNIPFSNAPGCNATAVGEFAFIAMLELAQRFNSPLKGKVVGIVGAGNTGTATAKCLQAYGIKVLLNDPIKAAEGDPRSFVSLDTIMAQADIISLHVPITHTGEHKTKHLFDEARLKALKPNTWLVNCCRGDVIDNQALIKVKQQRDDLKLVLDVWEGEPTPLPELVPLAEFATPHIAGYSLEGKARGTFMLYQNLCQLLNITADKSLLDLLPTFNIKAVELATAPNEKALLQLARFVYDLRDDDKMFRNTFLNENGFDTMRKNHQHRREFSALALAYDGQSEVDWLSNLGFSGVGQ
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOBD_SALPB
Sequence: MTITDLVLILFIAALLAYALYDQFIMPRRNGPTLLSIALLHRGRVDSVIFVGLVAILIYNNVTSHGAQMTTWLLSALALMGFYIFWIRTPRIIFKQRGFFFANVWIEYNRIKEMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLIENQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CACB2_RAT
Sequence: MVQSDTSKSPPIAAVAQESQMELLESAAPAGALGAQSYGKGARRKNRFKGSDDSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYLEAYWKATHPPSSNLPNPLLSRTLATSTLPLSPTLASNSQGSQGDQRTDRSAPRSASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPKEDYSHEHVDRYVPHREHNHREESHSSNGHRHREPRHRTRDMGRDQDHNECSKQRSRHKSKDRYCDKEGEVISKRRSEAGEWNRDVYIRQ
What is the function of this protein?
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:1370480, PubMed:12042350).  Plays a role in shifting voltage dependencies of activation and inactivation of the channel (PubMed:1370480, PubMed:12042350).  May modulate G protein inhibition (PubMed:11604404, PubMed:12042350, PubMed:1370480).  May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity).  Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: SYK_ALIFM
Sequence: MTEQVQLDENKLIAERRGKLDHIRQACKANGHPNDFRRDSLAGDLQAEFGEKTKEELEELNHVVAIAGRVMAKRGPFLLIQEVSGKIQAYAAKEVQKELKDKYQGLDIGDIIGVKGALHKSGKGDLYVNMEEYVLLTKALRPLPEKFHGLTDQEMRYRQRYVDLIVNDDSRHAFIVRSKVVAAIRNFMVDKGFMEVETPMMHVIPGGASARPFVTHHNALDVDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADYNDLMDLTEEMLSTVATSVLGSDKMPYGEHTVDFGGKYARMSMLDAIKQYNPDHSEIQALTYEGVKDRDLMVSIAKSVHVEVESFWTCGQLLEEIFGETAEPKLMQPTFITEYPADISPLARRNDDNDFITDRFEFFIGGREVANGFSELNDAQDQDERFKAQVNAKESGDDEAMYYDADYITALEHGLPPTAGQGIGIDRLVMLLTNTHTIRDVILFPSMRPQA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_ACIBS
Sequence: MINTSPLLNYVSSHHDIKAINQWRTDVEKQLQDSYENGQSIREIIKARSDLVDEALVFLWKHAELDQSKLGLFAVGGYGRREMLPYSDVDIMILSEDEISEENEKRISTFISSLWDVGNFKPGISVRTIQSCVEQAATDLTVATTLIEARLITGNTQLAKWPRRIVSQTWTDKTFYDAKMAEQAKRYHQHNNTESNLEPDIKNAPGGIRDINQIGWIAKRHFRVNRIYDLVHLGFISEFELAVLEEAESFLWEIRHHLHRLAKRDENRLLFDHQREIAAKFGYVRQEGQPVNYGVEQFMKRYYRTAQQVSTLNEMLLAYFSESVITPRLPNYERKIEVVNDHFKIVDNKIAVQHHKIFAEHPSAILELFYILANRPDIEGIRARTLRLLILAAKRINQSYRDNPEHQALFMSIIRSPYRLYDTLVAMKRYGVLGNYIPAFGQIMGLMQYDLFHIYTVDAHTLLLLRNLNRFREPEFAKEFPVVSSVFQRLARQDIVFIAALFHDIAKGRGGDHSELGAEDAIEFGRAHGFTERECKLIAWLIQNHLLMSLTAQKKDISDPDVVKDFAEKLGDMEHLDYLYTLTVADINATNPKLWNTWRASLMRQLYTHARDVIRTGLGRPVDYQMLIEDTKFAASELLVNNFALADVEKVWQELGDEYFIKESADEIAWHTQAILKHGDNPEPLVLLRAHRKAAQDAVQIFIYTRDQPNLFATTVAVLDRMNLDVQDAKIITASTAFSLDTYVVLDRFGTLLTDPEREETVKNALVKALSQPDQYPGLMQRRIPRQLRHFDIENTVDVTLNEALQQNMVEISTLDHPGLLARVGGLFMMQGLDIHSARIATLGERAEDIFFVTKKDGKPLNNEEVKLFSEKLKAALDEASNQICQH
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: PPK1_CAMCO
Sequence: MQTNPNMFLNRELSWLRFNSRVLDQCSRPLPLLERLKFVAIYCTNLDEFYMIRVAGLKQLFSAGVNISSSDEMSPLQQLKAIRKYLHKEKDLLEHYFNEIISDLEKENLFIKNYENLDNNLKQKVYEYFFSTIFPVIVPIAVDATHPFPHLNNLSFSLAVNICDNTHPELIKFGMIRIPRVLPRFYEVSANVYVPIESIVEKHTEEIFPGYKLLTSAAFRVTRNADMVIEEEEADDFMMILEQGLKLRRKGAFVRLQIQKGADEQIVEFLNTHMKIFHKDVYEYSILLNLPSLWQIAGNKTFTHLLSPLYTPKTLPPFDENLSIFDAIDKEDILIIQPFESFDPVYKFIKEASKDPEVISIRMTLYRVEKNSNIVQALIGAASAGIQVTVMVELKARFDEENNLHWAKALENAGAHVIYGITGFKVHAKVSQVIRKKGDKLKFYMHLSTGNYNASSAKIYTDVSYFTSKVEFARDTTSFFHILSGFSKNRRLQTLSMSPNQIKEKILEMIALEASKGSEGVIIAKMNSLVDSDIIKALYEASIKGTQIDLIVRGIFCLKPNEEFSKNILVRSIIGKYLEHARVFYFKHSEPNYFISSADWMPRNLERRLELMTPIYDERSKAKLAQFLRLQLSDNLLAYELQNDGEYAKVASNEKVIDSQQILEEYVSKIYKTLKKDTDQSRATHLASKLFKEN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: YQGF_BACFR
Sequence: MSRIVAIDYGRKRTGIAVSDTMQIIANGLTTVPTHELLDFITNYVKQESVERIIIGLPKQMNNEVSENMKNIEPFVRSLKKRLPDMPVEYVDERFTSVLAHRTMLEAGLKKKDRQNKALVDEISATIILQSYLETKRL
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPZ1_MOUSE
Sequence: MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).  The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
What are the official names of this protein?
Coatomer subunit zeta-1, Zeta-1-coat protein, Zeta-1 COP.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: PRIB_VIBVY
Sequence: MTNRMELSGTVVKDPIRSQSPAGISHCRFWLEHRSVVVEADLPRQVFCRMPVVVSGKGSQDITQQIVLGSNIKVSGFVAYQTGRNGVGKLVLHADDIIHI
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.