Protein: WRK70_ARATH
Sequence: MDTNKAKKLKVMNQLVEGHDLTTQLQQLLSQPGSGLEDLVAKILVCFNNTISVLDTFEPISSSSSLAAVEGSQNASCDNDGKFEDSGDSRKRLGPVKGKRGCYKRKKRSETCTIESTILEDAFSWRKYGQKEILNAKFPRSYFRCTHKYTQGCKATKQVQKVELEPKMFSITYIGNHTCNTNAETPKSKTCDHHDEIFMDSEDHKSPSLSTSMKEEDNPHRHHGSSTENDLSLVWPEMVFEEDYHHQASYVNGKTSTSIDVLGSQDLMVFGGGGDFEFSENEHFSIFSSCSNLS
What is the function of this protein?
Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways (PubMed:14742872, PubMed:16623907, PubMed:17310369, PubMed:28576847).  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).  Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression (PubMed:24104863).  Plays an important but not indispensable role in jasmonate and salicylic acid signaling (PubMed:18713432).  Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmonic acid (JA)-mediated signal pathway, thus determining the balance between these mutually antagonistic pathways (PubMed:14742872, PubMed:16623907, PubMed:18713432, PubMed:28837631).  Together with WRKY46, WRKY53 and WRKY54, prevents defense response to the necrotrophic pathogens P. carotovorum and B. cinerea, but promotes defense responses (including SA-induced pathogenesis-related (PR) genes expression) against biotrophic/hemibiotrophic SA-monitored pathogens (e. g.  P. syringae, E. carotovora subsp.  carotovora SCC3193 and E. cichoracearum), probably by regulating negatively the JA/ET and positively the SA signaling pathways (PubMed:28837631, PubMed:16623907, PubMed:22325892).  Contributes to the suppression of jasmonic acid (MeJA)-induced expression of JA-responsive genes (e. g.  PDF1. 2) (PubMed:22325892, PubMed:16623907).  Promotes susceptibility to JA-monitored pathogens (e. g.  A. brassicicola), probably by facilitating SA-controlled suppression of JA-mediated defense.  Represses the biosynthesis of the phytoalexin camalexin and indol-3-ylmethyl glucosinolate (IGS) (PubMed:16623907).  Represses both SA and JA/ethylene (ET) mediated defense marker genes expression (PubMed:17310369).  Negative regulator of SA biosynthesis (PubMed:28837631).  Negative regulator of EDS1-dependent defense against E. amylovora (PubMed:22316300).  Required for RPP4-mediated disease resistance and basal defense against H. parasitica, probably via late up-regulation (LURP) of resistance genes (e. g.  CML10/CaBP22 and LURP1) (PubMed:17313163).  Probably involved in defense responses toward insects (e. g.  P. xylostella and B. brassicae) (PubMed:25339349).  Together with WRKY54, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes (PubMed:17310369, PubMed:22268143).  Together with WRKY46 and WRKY54, promotes brassinosteroid (BR)-regulated plant growth but prevent drought response by modulating gene expression (PubMed:28576847).  In collaboration with WRKY54, prevents stomatal closure and, consequently, osmotic stress tolerance (PubMed:23815736).  Regulates rhizobacterium B. cereus AR156-induced systemic resistance (ISR) to P. syringae pv.  tomato DC3000 (PubMed:26433201).
What are the official names of this protein?
Probable WRKY transcription factor 70, WRKY DNA-binding protein 70.
What is the protein family that this protein belongs to?
Belongs to the WRKY group III family.
What are the subcellular locations of this protein?
Nucleus.