PharMolix/UniProtQA huggingface dataset:
Protein: CCME_SHEB2
Sequence: MNPRRKKRLTLAVALIGGVAAITSLLLYALNSNLNLFYTPSEIVHGKTDTGVKPEIGQRIRVGGMVTVGSMVRDPKSLHVQFAVHDSLGGEVLVTYDDLLPDLFREGQGIVAQGVLSADGKLEATEVLAKHDENYMPPEVAEAMGQKHEKLDYSQQKAPDTK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NAGZ_SHEON
Sequence: MSYLMLDLLSLDVSEAEAEMLRHPQVGGLILFSRNFTSREQLIALVQQIRQIRPEILIAVDHEGGRVQRFREGFTLIPAMGDILPAAKGDMALAKRWACELGFLMAIELLACDIDLSFAPVLDLNGISQVIGKRSFSANPDEVIALARSFIEGMAQAGMGAVGKHFPGHGSVAADSHIAQPIDEREGEVIFNQDILPFKELIFNGKLSGIMPAHVIYPKVDPNPAGFSSYWLKQILRKELGFNGVIFSDDLGMKGASFAGDYVGRAKAALDAGCDMILVCNDNPGVMTLLNGFVWPEAAPQHPASLLKPNMAQTALALENSARWENAKQLAEQIQLAQQAKV
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGFRL_MOUSE
Sequence: MKFWLLLGLLLLHEALEDVAGQHSPKNKRPKEQGENRIKPTNKKAKPKIPKVKDRDSTDSTAKSQSIMMQAMGNGRFQRPAATVSLLAGQTLELRCKGSKVEWSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSCWEQLCNGYICRRDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTILASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVIIVEDFETIDAGYYICTAQNLRGQTTVATTVEFS
What are the official names of this protein?
Platelet-derived growth factor receptor-like protein, PDGFR-like protein.
What are the subcellular locations of this protein?
Secreted.
Protein: STAT4_MOUSE
Sequence: MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALAFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETAMNSPYSAE
What is the function of this protein?
Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response.  Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:8700209).  Participates also in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (PubMed:34138758).  After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated.  Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes.  Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (By similarity).  Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (PubMed:14734615).  In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (By similarity).
What are the official names of this protein?
Signal transducer and activator of transcription 4.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein: JUNB_BOVIN
Sequence: MCTKMEQPFYHDDSYAAAGYGRTPGGLSLHDYKLLKPSLALNLSDPYRNLKAPGARGPGPEGNGGGSYFSSQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASGGPPAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGAGAAVGTGSSYPTATISYLPHAPPFAGGHPAQLGLGRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
What is the function of this protein?
Transcription factor involved in regulating gene activity following the primary growth factor response.  Binds to the DNA sequence 5'-TGA[GC]TCA-3' (By similarity).  Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
What are the official names of this protein?
Transcription factor JunB, Transcription factor AP-1 subunit JunB.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Jun subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYDND_RICCK
Sequence: MHKYRTHNCNALQISDVGKEVKLSGWVHRRRDHGNLVFIDLRDHYGITQIVFTDQNLQLMEMASRLRYESVITVIGKVVARSGDTINDTLTTGHIEILAREFIVESAADTLPFVINTEKDAPEDLRLKHRFLDLRREKLHNNIILRSQIISHIRHLMTARGFTEFQTPILTASSPEGARDFLVPSRMHSGKFYALPQAPQQFKQLLMVSGFDRYFQIAPCFRDEDARADRSPGEFYQLDVEMSFVTQEDVFSTIEPVMYDLFTKFTDKKVSETPFIRIPYNESMLKYGSDKPDLRNPIIIADVTEIFRDSDFTIFRENIKKGSVVRAIPAPKAAAHARSFFDKMIEFAISEGAGGLGYIQFSKNDKAKGPVAKFLSPQQLESLKATVNISDGDAVFFVSDKKEKAAKLAGKVRIRISDELDLLEKDCFKFCWITDFPFYELNEETAKIDFSHNPFSMPQGGLDALKNAKTTAELLELTAYQYDIVCNGIELSSGAIRNHKPEIMYKAFSIAGYSEEEVNKRFGSMIRAFKFGAPPHGGIAPGIDRIVMLLAEATNIREIIAFPLNQQAEDLLMNAPNYVEDKALKELGIMLLPSARKNVEQE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE23_CAMLA
Sequence: MHFTQQQLQRLMLHYAGKIAKDRKEQKIKLNYNEALAYICYELMELARKNLSVSELMSIGKTLLTSEDVIDGVASMLDEIQIELPFEDGTKLVTIHEPIANDDKIKAGEIFLSSEFIVLNENKTSIEIKVSNKGDRPIQVGSHFHFFEVNRFLSFDREKAYGKRLNIASGTSVRFEPGEEKTVSLIEFGGLKKVLGFNNLCDDFINDENKTKALSKAKEKGFL
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_ECO55
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_BARQU
Sequence: MAVININEVITHLLPGQTIAGLDLGKKTIGIAVSDRGLTFSNPRSVLQRKKLTVDARTLIQIFDRENVGVVIIGLPLNMNGSSGPRAQATRTFVNNMEAYTEIPFVFWDERLSTIAAERSLLEMDVSRAKRATRIDSAAAAFILQGALNRIQNLHYMEG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMH2_DROME
Sequence: MLLHESAASMEQSMPENLSTHMYGECEVNPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTPQEALDYSSDSCSSVDLSEQADEDDNIEINVVE
What is the function of this protein?
May play a role in pattern formation during embryonic and imaginal development.  Is not essential for visceral muscle morphogenesis.
What are the official names of this protein?
Homeobox protein H2.0.
What is the protein family that this protein belongs to?
Belongs to the H2.0 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DR9C7_MOUSE
Sequence: MAALTDFAFMYRWFKNCNLVKNLSEKYVFITGCDSGFGNLLAKQLVDRGMKVLAACLTEEGAQKLLQDTSHQLQTFLLDVTKSENVKEAAQWVRDQVGEQGLWALVNNAGVGLPSGPNEWLTIKDFVKVININLVGLIDVTLNMLPMIKKARGRVVNMSSSGGRVAIFGGGYCVSKFGVEAFSDSIRRELHFFGVKVSIIEPGNYKTSILGQEALESRMKKLWDRLPQETRDSYGEEYFQTYTKKLVNLMRSAEPRISDVTNSMEHAIVSRSPRIRYNPGLDVKFLYLTLAKLPTPVTDFILSRYLPRPADSV
What is the function of this protein?
Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH.  Has apparently no steroid dehydrogenase activity (By similarity).
What are the official names of this protein?
Short-chain dehydrogenase/reductase family 9C member 7, Orphan short-chain dehydrogenase/reductase, SDR-O, RDH-S.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_ECO55
Sequence: MSWISPELIEILLTILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_ECOBW
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: MNMA_PSYIN
Sequence: MTDNSQVKVIVGMSGGVDSSVSAYLLQQQGYLVEGLFMKNWEEDDTDQYCAAAQDLEDAQSVCDKLGIPLHTINFAAEYWDNVFEHFLAEYKAGRTPNPDIMCNKEIKFKAFLEFAAEDLGADYIATGHYVRRREVDGHVQLLRGLDNNKDQSYFLYAIGEKQIAKSLFPVGELEKPEVRRIAEQQDLITHNKKDSTGICFIGERKFTDFLQEYLPAQPGDIVTPTGEVIGQHQGLMYHTLGQRKGLGIGGLQNSNENPWYVVGKDMDNNRLLVAQGADHPALFSYGLIAKQCDWVDRTPKKSTFRCTVKTRYRQQDIPCTVTPLDDDTLKVIFDTAQAAVTPGQSAVFYNDEVCLGGAIIEEHLQK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_NEIMB
Sequence: MMFDKHVKTFQYGNQTVTLETGEIARQAAAAVKVSMGDTVVLVAVTTNKEVKEGQDFFPLTVDYLERTYAAGKIPGGFFKREGKQSEKEILTSRLIDRPIRPLFPEGFYHDIQIVAMVVSVDPEIDSDIPAMLGASAALVLSGVPFAGPIGAARVGYVNGVYVLNPTKAELAKSQLDLVVAGTSKAVLMVESEAKILPEDVMLGAVVYGHDQMQVAINAINEFADEVNPELWDWKAPETNEELVAKVRGIAGETIKEAFKIRQKQARSAKLDEAWSAVKEALITEETDTLAANEIKGIFKHLEADVVRSQILDGQPRIDGRDTRTVRPLNIQTSVLPRTHGSALFTRGETQALAVATLGTSRDEQIIDALSGEYTDRFMLHYNFPPYSTGEVGRMGAPKRREIGHGRLAKRALLAVLPKPEDFSYTMRVVSEITESNGSSSMASVCGGCLSLLSAGVPLKAHVAGIAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTTEGVTALQMDIKIQGITKEIMQIALAQAKEARLHILDQMKAAVAGPQELSAHAPRLFTMKINQDKIREVIGKGGETIRSITAETGTEINIAEDGTITIAATTQEAGDAAKKRIEQITAEVEVGKVYEGTVVKILDNNVGAIVSVMPGKDGLVHISQIAHERVRNVGDYLQVGQVVNVKALEVDDRGRVRLSIKALLDAPAREENAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP82_YEAST
Sequence: MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDKKPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSAFSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDEPTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding.  Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate.  Finally, ATP hydrolysis results in the release of the substrate.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.  Required for growth at high temperatures.
What are the official names of this protein?
ATP-dependent molecular chaperone HSP82, 82 kDa heat shock protein, Heat shock protein Hsp90 heat-inducible isoform.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIF2_YEAST
Sequence: MSITSEELNYLIWRYCQEMGHEVSALALQDETRVLEFDEKYKEHIPLGTLVNLVQRGILYTESELMVDSKGDISALNEHHLSEDFNLVQALQIDKEKFPEISSEGRFTLETNSESNKAGEDGASTVERETQEDDTNSIDSSDDLDGFVKILKEIVKLDNIVSSTWNPLDESILAYGEKNSVARLARIVETDQEGKKYWKLTIIAELRHPFALSASSGKTTNQVTCLAWSHDGNSIVTGVENGELRLWNKTGALLNVLNFHRAPIVSVKWNKDGTHIISMDVENVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSLGVDVEWVDDDKFVIPGPKGAIFVYQITEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTLRIWHGGNGNSQNCFYGHSQSIVSASWVGDDKVISCSMDGSVRLWSLKQNTLLALSIVDGVPIFAGRISQDGQKYAVAFMDGQVNVYDLKKLNSKSRSLYGNRDGILNPLPIPLYASYQSSQDNDYIFDLSWNCAGNKISVAYSLQEGSVVAI
What is the function of this protein?
Antagonizes telomeric silencing in yeast.  May recruit SIR4 to non-telomeric sites or repression.
What are the official names of this protein?
SIR4-interacting protein SIF2.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAP22_PENRW
Sequence: MAAQTTEKLDQLDLNVQAAPTADQVPAEAEEDSDDAQDEGAAEAGAAGAGSTLADKKKKKKKPKKKSKKKGGAKVQSEPPRVPVSNLFPNGQYPEGEIVEYLNDNAYRTTNEEKRYLDRMNNDFLQEYRQGAEVHRQVRQYAQKNIKPGQTLTEIAEGIEDSVRALTGHSGLEEGDNIKGGMGFPCGLSINHCAAHYTPNAGNKMVLNEGDVMKVDFGAHLNGRIVDSAFTMTFDPVYDPLLAAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVEINGTMHPVKCIRNLNGHNIDQHVIHGGKSVPIVKSTDQTKMEEGEVFAIETFGSTGKGYVREEMETSHYALAADAPNVPLRLSSAKNLLNLINKNFGTLPFCRRYIDRLGQDKYLLGLNNLVSSGIVQDYPPLCDIKGSYTAQYEHVCFYFGVFSTLIVY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3353_ARATH
Sequence: MARTKNAGVPLAAEVVSQTINDEVVVASAAEVDSEATNLISNDDRADSDEETEALQPLKMYFGPSDYTKPFKITAKCYLHKAVGLLESHLEESELKWFLEHPQFKHFFHMHKDPNHKVMGMWLLFIRTTCLDKKGSMVYCQWRTDPMFGPGATIQYPDVEKKLLSMKKPSEARLRVVVLYFLCNRWKGVVADLELCKTFPWGKNAFEENYLAFEAIPVLRKNFCEDIESADPQCPRMCKMKFKSSTMKGFPMSDVYDKLGTTKSILAPTPDENLLLKRIMDKECGVNDVDDLIADGWKKRLVDEERTICFEPLFNEDVAHQSFVANNAPSTVVQAPRKAAVEKKGKGKTAAALTSPSDEGLTEVVNEMKNLMENGFKSMNKRMTNFSKKYEEQDKRLKLMETAIKSIQSSTGTDDAYGSKEIDDRENELEEGSDANGGDNEREVREKETEIDKEVAQGDNEREVGEKETEIDKEVGQGDSDIFDGNKDMELNKEVAESTIGVAESEKDKEVTESEKDKEVAESEIGVPESEKDIEVADSEKDKEVPQDDEMDGGKVTEPSKKRGKSHDDGDDPSEGCVKKPKVVKKVAKSRTDAKPVYRSPIQTRYARKKTKKNV
What are the official names of this protein?
Uncharacterized protein At3g43530.
Protein: MNMA_PSEFS
Sequence: MRDPAPSDTQKKRVIVGMSGGVDSSVSAVLLMEQGYEVEGLFMKNWEEDDGTEYCTAMDDLADAQAVCDKIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYAMMLGADLIATGHYVRRRDIDGRTELLKGLDPNKDQSYFLHAVGGEQIAKTLFPVGELEKPEVRKIAEKHGLATAKKKDSTGICFIGERRFSDFLKQYLPAQPGEIKTTDGEVIGRHHGLMYHTIGQRQGLGIGGLKDAGEEPWYVLVKDLDNNVLIVGQGNEHPLLFSGALLASEIYWVNPIDLSTPRRLTAKVRYRQGDQPCTLEKTATGYRATFDDPQRAVTPGQSVVFYDGEICLGGGVIEVAEAWSNPA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LLDD_ECOUT
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQVLGKELPAALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y125_AQUAE
Sequence: MKEKLALALLSFFLGLGSFFSFYVAPTLFKVLERQQAGAVVEKVFPVYFGLGIILVGISLFLGRDSGKLFLSLGILNLLLLLLQEFIVIPKLHGLKATNYELFLKYHGVSMGINLAILLLTLGKVLILIFKR
What are the official names of this protein?
Uncharacterized protein aq_125.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPA_BACC4
Sequence: MGVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICELIYATKQKEEA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: COX2_SYNCA
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMVPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLEMVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.