PharMolix/UniProtQA huggingface dataset:
Protein: EFP_MYCSJ
Sequence: MASTADFKNGLVLQIDGQLWQIVEFQHVKPGKGPAFVRTKLKNVVSGKVVDKTYNAGVKVETATVDRRDATYLYRDGSDFVFMDSEDYEQHPLPESLVGRAADFLLESMPVQIAFHDGVPLYLELPVTVELLVASTEPGLQGDRSSAGTKPATMETGAEIQVPLFINTGDKLKVDSRDGSYLGRVNA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_MARMS
Sequence: MAYLELDLQIATEETANLPSEADFRLWVEKALPEVDEEFEVTIRIVDEEESHALNHEYRGKDKPTNVLSFPFEAPPGLELPLLGDLVICAQIVAKEAAEQNKELFHHWAHMTIHGILHLRGYDHINDDEADEMESIETELLASLSISDPYLIKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_VARPS
Sequence: MARYLGPKAKLSRREGTDLFLKSARRSIQDKAKFDSKPGQHGRTSGQRTSDYGLQLREKQKVKRMYGVLEKQFRRYFEEADRRRGNTGANLLFILESRLDNVVYRMGFGSTRAEARQLVSHKAITVNGQSVNIPSYLVKTGDVIAVRDKSKKQTRIAEALQLAQQVGIPAWVEVNADKAEGTFKKVPDRDEFAADINESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GSA_CLAMS
Sequence: MTHSQDLFDRARDVIPGGVNSPVRAFGSVGGTPRMMVRAAGPYVTDADGVEYVDLVNSWGPAILGHARPEVVKAVQDAAALGLGFGATTPAETELAELVTERVRVAGVDGSPDRRPVEKLRLVSTGTEATMTAIRLARGFTGRDLLVKFAGHYHGHSDSLLAEAGSGVATLALPGSAGIPEAIAAQTIVVPYNDLGAVRAVFAEHGPRIAAVITEAAAANMGVVPPLPGFTAELARIAHDNGSLLISDEVLTGFRVHPAGYWGLDNDGLAADHPDAWTPDLVTYGKVIGGGLPVAALGGRADVMDHLAPLGPVYQAGTLSGNPVAVAAGLTTLRLADADVYRALDIAADILIYAVELAFDRAGLAYSVQRAGSLFSFTFGTPPEHGITDYATVQAQETWRYPAFFHSMLDQGVSLPPSVFEAWFVSAAMDEASLDRVIRALPAAARAAAAATPPA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_RHOOB
Sequence: MGTVHLIDHPLVQHKLTMMRRKDASTNSFRRLANEISALMTYEVLRDIPMQEIEIETPLEVTTGRVIDGKKLVFVSILRAGTGILDGMLTIVPGARVGHIGLYRDPRTLVAVEYYFKMPGDLHERDVVVVDPLLATGNSAVAAVERLKECGPKSIKFVCLLTCPEGVAALDKAHPDVPIYTAAVDRQLDEHGYILPGIGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PME45_ARATH
Sequence: MAFQDFDKIQERVNAERKRKFRKRIILGVVSVLVVAAAIIGGAFAYVTYENKTQEQGKTTNNKSKDSPTKSESPSPKPPSSAAQTVKAGQVDKIIQTLCNSTLYKPTCQNTLKNETKKDTPQTDPRSLLKSAIVAVNDDLDQVFKRVLSLKTENKDDKDAIAQCKLLVDEAKEELGTSMKRINDSEVNNFAKIVPDLDSWLSAVMSYQETCVDGFEEGKLKTEIRKNFNSSQVLTSNSLAMIKSLDGYLSSVPKVKTRLLLEARSSAKETDHITSWLSNKERRMLKAVDVKALKPNATVAKDGSGNFTTINAALKAMPAKYQGRYTIYIKHGIYDESVIIDKKKPNVTMVGDGSQKTIVTGNKSHAKKIRTFLTATFVAQGEGFMAQSMGFRNTAGPEGHQAVAIRVQSDRSVFLNCRFEGYQDTLYAYTHRQYYRSCVIIGTVDFIFGDAAAIFQNCDIFIRKGLPGQKNTVTAQGRVDKFQTTGFVIHNCTVAPNEDLKPVKAQFKSYLGRPWKPHSRTVVMESTIEDVIDPVGWLRWQETDFAIDTLSYAEYKNDGPSGATAARVKWPGFRVLNKEEAMKFTVGPFLQGEWIQAIGSPVKLGLYDA
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Putative pectinesterase/pectinesterase inhibitor 45.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MIAA_ACIET
Sequence: MPADHIPALALAGPTASGKTAAAFAIADALAPRLPVEIISVDSALVYSGMDIGTAKPTPAEQARVPHHLIDIRDPLQAYSAAEFVQDATRLIGEIRARGALPLLVGGTMLYFKALFDGIDDMPPADAAVRARLEAQAAAIGWSGMHAELARVDPPTAARLAPGDSQRIQRALEVWHVSGRPLSSFHTTKTVAASARPMSAASLFSLEPHDRAWLHGRIAERFHAMLAAGFLDEVLRLRARGDLHADLPSMRCVGYRQAWESLDGLYPMSSLPERGIAATRQLAKRQITWLRSMPERHSIACDAPDATAQLVQAVRARVWGGGA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: YQGF_STRCO
Sequence: MSTPENDQADGPRMRRGRRLAVDVGDARIGVASCDPDGILATPVETVPGRDVPAAHRRLRQLVAEYEPIEVVVGLPRSLKGGEGPAAAKVRRFTQELAKGIAPVPVRLVDERMTTVTASQGLRASGVKSKKGRSVIDQAAAVIILQQALESERVSGRPPGEGVEVVI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APDG_EMENI
Sequence: MAEISSVPFAEPPYLRGLPSPYYNESHRRFQKACRAFLYENLLKHAMEWEKAGTVPEHVFSDFCKANMLLPNLPAPLPVAWLKRLGIHDILGVKVEEWDYLHTGIYSDEMARSGLSGPSGSLTAGFAFGTPPIIKYGSKELQEKFLPDLLTGKKRNCIAITEPDAGSDVAGITTTATKSADGKYYIVNGNKKWITNGIWSDYSTMAVRTGGPGAGGLSLLVVPLKNYPGVTMQRLKVSGQITGGTTYIELDEVKVPVENLIGLEGDGMKMIMNNFNHERLTIAVGVTRQARVALSTAFSYCLKREAFGKTLMDQPVVRHRLAKAGAELETMWAFVEQLLYQLTNLPKEEADRQLGGITAMAKAKGAMVLNECAQTAVLLFGGAGFTKQGQGELAEAILRDVPGARIPGGSEDVLLDLSIRQLVKLFKAEEKKLGKARI
What is the function of this protein?
Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, Ref. 5).  The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130).  The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130).  The growing polyketide chain then elongates into a tetraketide (PubMed:20828130).  The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130).  Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235).  The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130).  The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130).  Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref. 5).  ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref. 5).  Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130).  A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821).  The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref. 5).  Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (PubMed:17369821) (Probable).
What are the official names of this protein?
Acyl-CoA dehydrogenase apdG, Aspyridones biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: BLLF2_EBVG
Sequence: MCPPVRQRPAQAPPAKRQALETVPHPQNRGRLMSPKARPPKMQRRPRPPVAKRRRFPRSPQQVERPILPPVESTPQDMEPGQVQSPPQITAVIQLRQERDTMRPPIYLPALLANCGPAGLLRAHRLPQPKPPCQSRQRPSPDSQTSPC
What are the official names of this protein?
Uncharacterized protein BLLF2.
What is the protein family that this protein belongs to?
Belongs to the Epstein-Barr virus BLLF2 family.
Protein: RL21_ECO27
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ARC_STANL
Sequence: MSRNDDEQARGSRWERETQDLSTQVEYLQEELALARRKLTETPGHVRLLEERLAATKAQVERMSEQNERLVATLKDAREQIVTLKEEIDRLAQPPSGYGVFIEAREDGTVDVFTGGRKMRVALSPSIEPESLRRGQEVLLNDALNVVESLGFERAGDVVTLKELIESDTGHPDRALVTSHADEERVVHLADSLTNAPLRAGDSLLVEPRSGYAYERIQKSEVEELVLEEVPDVDYESIGGLDGQIELIRDAVELPFLHADLFAEYELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKVAEARGDDFTGGDRAKSYFLNIKGPELLNKYVGETERHIRLVFQRAREKASEGQPVIVFFDEMDSVFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAESARDIFSKYVTTKLPLNEADLAEQGGSREACVQEMIQQAVERMYTETEENRFLEVTYADGDKEVLYFKDFNSGAMIQNIVDRAKKMAIKEFLNSQRKGLRLQHLLDACVDEFRENEDLPNTTNPDDWARISGKKGERIVYIRTLVSGKGDESGRSIDTVSNTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: SMG_NEIMA
Sequence: MTEVIAYLIEHFQDFDTCPPPEDLGMLLEEAGFDTMEIGNTLMMMEVLLNSSEFSAEPADSGALRVYSKEETDNLPQEVMGLMQYLIEEKAVSCEQREIIIHALMHIPGDEITVDTAKVLTLLLLWANKSELPVLVGDELMSALLLDNKPTMN
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: B3GA2_RAT
Sequence: MKSALCNRFFILLPWILIVIIMLDVDPRRPAPQLTSRPYFSPHTVGCGGSRVPLRRSSPGRDAAEKRNESRPQLQPEPRLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDRATRSELVSSFLARAGLPNTHLHVPTPRRYKRPWLPRATEQRNAGLAWLRQRHQHQSAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVKNGKVVGWYTGWREDRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVDELEPKANNCTKVLVWHTRTEKVNLANEPKYHMDTVNIEV
What is the function of this protein?
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.  Substrates include asialo-orosomucoid (ASOR), paragloboside (lacto-N-neotetraosylceramide), Gal-beta-1,4-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine and Gal-beta-1,3-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine.
What are the official names of this protein?
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2, Beta-1,3-glucuronyltransferase 2, GlcAT-D, UDP-glucuronosyltransferase S, GlcAT-S, Glucuronosyltransferase S.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 43 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: DXR_PROMH
Sequence: MKQITILGSTGSIGTSTLSVIENNPDEFQVLALVAGKNATKMAQQCRAFQPKYAVMSDEKSAGELKQLLANTSCKTEILSGSDAVNEIAALDEADQVMSAITGVAGLKPTLAAIEKGKRILLANKESLITSGRLFFDAVAKYGAKVLPIDSEHNAIYQSLPTGIQDNLGHASLEAHGITSILLTGSGGPFRYTPLDELDAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARYFFNASEAEMEVIIHPQSVIHSMVRYRDGSIIAQIGEPDMRTPIAYSMAYPHRTQSGAKALDFFEIQALEFIRPDYQRYPCLALAIEASQRGQASTTVLNAANEVVVDAFLNEKVKFTDIAKINRKVVEHFDLSEPQSIDDVLEIDKLARLQTQQIIAQIV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NDHH_PHAVU
Sequence: MNISTIRKDFMIVNMGPHHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNGPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFREREFIYDLFEAATGMRMMHNFFRIGGVATDLPYGWVDKCSDFCDYFLTSIAEYQKLITRNPIFLERVEGVGVVDVKEVINWGLSGPMLRASGIQWDLRKVDNYECYEEFHWEVQWQKEGDSLARYLVRIGEMVESIKIIQQALEGLPGGPYENLEIRCFDREKEPEWNEFEYRFISKKSSPSFELPKQELYVRIEAPKGELGIFIIGDQNGFPWRWKIHPPGFINLQILPQLVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: DNAK_STAAE
Sequence: MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNEADSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: AAE20_ARATH
Sequence: MDDLALCEANNVPLTPMTFLKRASECYPNRTSIIYGKTRFTWPQTYDRCCRLAASLISLNISKNDVVSVMAPNTPALYEMHFAVPMAGAVLNPINTRLDATSIAAILRHAKPKILFLDRSFEALARESLHLLSSEDSNLNLPVIFIHENDFPKRASFEELDYECLIQRGEPTPSMVARMFRIQDEHDPISLNYTSGTTADPKGVVISHRGAYLCTLSAIIGWEMGTCPVYLWTLPMFHCNGWTFTWGTAARGGTSVCMRHVTAPEIYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGPVHVLTGGSPPPAALVKKVQRLGFQVMHAYGQTEATGPILFCEWQDEWNRLPENQQMELKARQGISILGLADVDVKNKETQKSAPRDGKTMGEILIKGSSIMKGYLKNPKATFEAFKHGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEKSETTIKEDRVDKFQTRERNLIEYCRENLPHFMCPRKVVFLEELPKNGNGKILKPKLRDIAKGLVVEDEINVIAKEVKRPVGHFISRL
What is the function of this protein?
Benzoate--CoA ligase involved in benzoyloxyglucosinolate biosynthesis in seeds.  Glucosinolates are secondary metabolites involved in pathogen and insect defense of cruciferous plants.
What are the official names of this protein?
Benzoate--CoA ligase, peroxisomal, Acyl-activating enzyme 20, Protein BENZOYLOXYGLUCOSINOLATE 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: LIS12_SORMK
Sequence: MAQAQIGTPLLTTRQAEELHKSILAYLSSKNLASTAATLRDELPDLAEVTFDTEKAKKYEGLLEKKWTSVVRLQKKILDLESRNTLLQSEIDNATPSSLSRRTQDPTNWLPKAPPRYVLESHRLPVTCVAFHPVFTSLASGSEDYTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGGTLLASCSSDLTIKLWDPSDEYKNIRTLPGHDHIVSSVRFIPSGAAGAPASGNLLVSASKDNSLKIWDVTTGYCVKTILGHVDWPRAVCPSHDGRYLLSTGSDKSVRLWDLAGGRDAECRLVMFGHENYNLCCAFAPPTAYAYLAKLAGLDRPPPLGASAEFMATGSRDKQIRLWDGRGNCVKVLVGHDNWVRGLVFHPGGKYLLSVADDRTMRCWDLSQEGKCVQTLTGVYEGFVSCIRWAPPVVKDADAMAANTKSGGTGPLADTVVAARRRAATVGSVNASVQIRCVVATGSVDGTEGKVRIFAN
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1-2, Lissencephaly-1 homolog 2, LIS-1 2, nudF homolog 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: DUT_THEPX
Sequence: MSIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPNFEAQIRPRSGLALNYGITLLNTPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVINQIVRPTIVEAEILSETKRDEGGFGHTGI
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: SHS1_YEAST
Sequence: MSTASTPPINLFRRKKEHKRGITYTMLLCGPAGTGKTAFANNLLETKIFPHKYQYGKSNASISSNPEVKVIAPTKVVSFNSKNGIPSYVSEFDPMRANLEPGITITSTSLELGGNKDQGKPEMNEDDTVFFNLIMTHGIGENLDDSLCSEEVMSYLEQQFDIVLAEETRIKRNPRFEDTRVHVALYFIEPTGHGLREVDVELMKSISKYTNVLPIITRADSFTKEELTQFRKNIMFDVERYNVPIYKFEVDPEDDDLESMEENQALASLQPFAIITSDTRDSEGRYVREYPWGIISIDDDKISDLKVLKNVLFGSHLQEFKDTTQNLLYENYRSEKLSSVANAEEIGPNSTKRQSNAPSLSNFASLISTGQFNSSQTLANNLRADTPRNQVSGNFKENEYEDNGEHDSAENEQEMSPVRQLGREIKQENENLIRSIKTESSPKFLNSPDLPERTKLRNISETVPYVLRHERILARQQKLEELEAQSAKELQKRIQELERKAHELKLREKLINQNKLNGSSSSINSLQQSTRSQIKKNDTYTDLASIASGRD
What is the function of this protein?
Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 min before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck.  This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck.  The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle.  Many proteins bind asymmetrically to the septin collar.  The septin assembly is regulated by protein kinases GIN4 and/or CLA4.  May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage.  Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
What are the official names of this protein?
Seventh homolog of septin 1, Septation protein 7.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Bud neck. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate (By similarity).
Protein: METK_BURVG
Sequence: MANDYFFTSESVSEGHPDKVADQISDAILDAILEQDKYSRVAAETLCNTGLVVLAGEITTTANIDYIQIARDTIKRIGYDNTDYGIDYKGCAVLVAYDKQSPDIAQGVDRAHDDNLDQGAGDQGLMFGYACDETPELMPLPIYLSHRLVERQASLRRDGRLPWLRPDAKSQVTIRYVDGKPDSIDTVVLSTQHAPDIELPALREAVIEEIIKPTLPADLIKGDIKFLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLASRALIQVSYAIGVAEPTSVMVNTFGTGRVSDAVITKLVREHFDLRPKGIIKMLDLLRPIYEKTAAYGHFGREEPEFSWEATDKALALAEAAGVEPTARVA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTBP3_HUMAN
Sequence: MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI
What is the function of this protein?
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.  Plays a role in the regulation of cell proliferation, differentiation and migration.  Positive regulator of EPO-dependent erythropoiesis.  Participates in cell differentiation regulation by repressing tissue-specific exons.  Promotes FAS exon 6 skipping.  Binds RNA, preferentially to both poly(G) and poly(U).
What are the official names of this protein?
Polypyrimidine tract-binding protein 3, Regulator of differentiation 1, Rod1.
Protein: MIAB_THEMA
Sequence: MRFYIKTFGCQMNENDSEAMAGLLVKEGFTPASSPEEADVVIINTCAVRRKSEEKAYSELGQVLKLKKKKKIVVGVAGCVAEKEREKFLEKGADFVLGTRAVPRVTEAVKKALEGEKVALFEDHLDEYTHELPRIRTSRHHAWVTIIHGCDRFCTYCIVPYTRGRERSRPMADILEEVKKLAEQGYREVTFLGQNVDAYGKDLKDGSSLAKLLEEASKIEGIERIWFLTSYPTDFSDELIEVIAKNPKVAKSVHLPVQSGSNRILKLMNRRYTKEEYLALLEKIRSKVPEVAISSDIIVGFPTETEEDFMETVDLVEKAQFERLNLAIYSPREGTVAWKYYKDDVPYEEKVRRMQFLMNLQKRINRKLNERYRGKTVRIIVEAQAKNGLFYGRDIRNKIIAFEGEDWMIGRFADVKVEKITAGPLYGKVVWVEKTPSPVSSSE
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.