PharMolix/UniProtQA huggingface dataset:
Protein: LCMT1_HUMAN
Sequence: MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWATKGGNELGLKEITY
What is the function of this protein?
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
What are the official names of this protein?
Leucine carboxyl methyltransferase 1, Protein-leucine O-methyltransferase, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: EFP_ACIET
Sequence: MKIAQEIRAGNVIMQGKDPMIVLKTEYARGGRGAATVRMKLKALLSNMGTEVVFKADDKIDNVILDKKECTYSYFADPMYVWMDAEYNQYEVEASNMGDAISYLEDGMAAEVVFYDGKAISVELPTSVEREITWTEPAVKGDTSGKVLKPAKIATGFEVAVPLFVDQGDKIEIDTRTGEYRKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCR_STAEQ
Sequence: MTGNQMFCRENELDESFKQLASYINIPVGVLLPFKSQCFVRHYNKGQIVYYSSDETTHIYLLLKGNIMRENFNLNGDVYRYLNREKVLFPLNNLFQDKVPNEMCTALTDCEMIGIPRDLIEYLCKNHEEIFVKLFSLLSETQCQHIEYNMALTSKLAKERVTKILRYLCQTVGYDHDEFYEIKHFMTIQLLSDMAGISRETTSHIINELKEEKILFKNSKNWLVSKDL
What is the function of this protein?
Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism.  May also control the expression of genes encoding proteins which are involved in anaerobic metabolism.  Can bind cyclic AMP (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator ArcR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_STREM
Sequence: MANKKIRIRLKAYEHRTLDTAAEKIVETATRTGATVAGPVPLPTERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVKIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PTH_HALS3
Sequence: MKQVIAARTDIGMGQGKLAAQVAHASLNAYEYTDDRAVRRWKDEGQTKVVVKVGSERELYERSEEAKRAGLPTGLISDAGRTQLEPGTPTALAIGPAPDADVDQITGDLSLF
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1B_NOCFA
Sequence: MTATPAQRRPALPATRPYPARHGPKGSYLRKMVTTTDPKDLGVLYLVSATGFFLIGGLLALLMRGELARPGLQFLSAEQYNQLFTMHGTIMLLFYATPVVFGFANAVLPLQIGAPDVAFPRLNAFSYWLYLFGATMATAGFLTPGGAADFGWTAYTPLSLSEHSPGVGADLWILGLAVSGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILITSILVLLAFPILTAALMALAYDRHLGGHIYDPANGGAILYQHLFWFFGHPEVYIIALPFFGIISEVIPVFSRKPIFGYTALVYATLAIAALSMAVWAHHMYATGAVLLPFFSMMTFLIAVPTGVKFFNWIGTMWKGQITFETPMLFAIGFIVTFLLGGLSGVILASPPLDWHVTDSYFVVAHFHYVLFGTIVFATFAGIYFWFPKLTGRFMDERLGRLHFWTTFLGFHLTFLVQHWLGNEGMPRRYADYLPSDGFTGLNTVSTIGSFLLGISMVTFVWNGFKSFRYGEVVTVDDPWGAGNSLEWATTCPPPRHNFYELPRIRSERPAFELHYPHMAERMRAEAHAGRRAGHGAGAELSVPSTVATKDDDHTS
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1-beta, Cytochrome aa3 subunit 1-beta, Cytochrome c oxidase polypeptide I-beta.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HMGN4_BOVIN
Sequence: MPKRKAKGDAKGDKGKVKDEPQRRSARLSAKPALPKPEPRPKKAPAKKGEKLAKGRKGKAEVSKDGNNPAKNRDASTVQSQKAEGTGDAK
What are the official names of this protein?
High mobility group nucleosome-binding domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the HMGN family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LFTR_HYDCU
Sequence: MSEPIHQPFWLDSKPVVFPPTHLAMTEPDGLLAVGGDLTPEWLLNAYHKGIFPWFNEDDPILWWTPNPRSVLFINSLKVRRSLIKTIRKQQFTVTLDQQFEDVMHQCANIERHDQDGTWISEEMLSAYTQLHKSGHAHSVEVWKDNQLVGGLYGVAIGKVFFGESMFSKVPDASKIALVALCQQLKAWGFRIIDTQMETAHLRSLGATLISREYFESILKQETHKDFAPKPWTLEVDWQAPFLAQPTIKKQKTTTP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGD_BRUME
Sequence: MTDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETLKTQAEKLWHLSNVYEIPAQEKLGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSGHPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEGFDQVPFGDEAALRAAITPETAGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIRPDIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGFMENVQATALVMKQGLASLVDRYPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVGAGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPISKTV
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEAHB_ARATH
Sequence: MRNSFPPSDGGRSTTDRRQQSFPSSSTNRYNSRSAQSSPPLNHCTTWNQQHSQYHNTNFPPNYRRDRAPSSGFSPPVTRARPNFIVQLLHPAAANSDTKLSKKQEIESIALLCEIPEESVHVPQFGCIAASFSFRQWVDARSAVVALWDYRLQGRHDFVPELIPNVVVPSDMDELKDRLRDLFSSHVLSLMENGQGVKKVRMEIDDKSRQVASFSSKRGLKFEVFEKKKALEAERDLVVNRLDEFNNAMKSILRYLIGQDGYEFDVDDEDDEDVAVFSLEGAYDWRRIHYLILRECRRLEDGLPIYAYRRQILKKIHCEQIMVLIGETGSGKSTQLVQFLADSGVAASESIVCTQPRKIAAMTLTDRVREESSGCYEENTVSCTPTFSSTEEISSKVVYMTDNCLLQHYMKDRSLSGISCVIIDEAHERSLNTDLLLALLRKLLSRRIDLRLVIMSATADANQLSQYLFDCGILHVNGRNFPVEIVYSPSGTEENSVVGRIASYAGDVVKMAVEIHKTEKEGTILAFLTSQAEVEWACERFVAPSAIALPLHGKLSFEEQFMVFQNYPGRRKVIFATNIAETSLTIPGVKYVIDSGMVKESKYEPRTGMSILKVCQVSQSSARQRAGRAGRTEPGRCYRLYSKTDFDSMNLNQEPEIRRVHLGVALLRMLALGIDNIAAFEFVDAPVPEAIAMAIQNLVQLGAVVEKNGVLELTQEGHCLVKLGLEPKLGKLILGCFRHRMGKEGIVLAAVMANASSIFCRVGNFDDKMKADRLKVQFCNDNGDLFTLLSVYKEWASLPRDRRNKWCWENSLNAKSMRRCEDTVKELEICIERELTLVSPSYWVWNPNEGTKHDKYLKMVILASLAENVAMYTGYDQLGYEVALTSQQVQLHPSCSLLAFGQKPSWVVFGELLSIVDQYLVCVTAFDFEALYMLDPPPPFDASQMDERRLRVKKVVGCSSTVLKRFCGKSNRSLLSIVSRARSLCSDERIGIQVDVDQNEIRLYASPLDMEKVSALVNDALECEKKWMRNECLEKYLFHGRGQIPIALFGSGAQIKHLEVDQRFLTVDVHYYGDDVVDDRELLTFLEKKIDGCICSIYKFAANKQDCDEKEKWGRITFLTPESAMKATEIQKFDFKGSVLKVFPSLSTGGGIFKMPYFSSVTAKIRWPRKESSGRGCLKCPSGDIHSILGDITSLEIGTNYVHIQRDQLSNDSILISGLGDLSEAEVLDVLEFRTQRRDLNFFIFRKKYSVQCPSPTACEEELHKRIFARMSAKNPEPNCVQVQVFEPKEDNYFMRALIKFDGRLHLEAAKALQELNGEVLPGCLPWQKIKCEQLFQSSIICSASIYNTVKRQLNVLLARFERQKGGECCLEPTHNGAYRVKITAYATRPVAEMRRELEELLRGKPINHPGFTPRVVQHLMSRDGINLMRKIQQETETYILLDRHNLTVRICGTSEKIAKAEQELVQSLMDYHESKQLEIHLRGPEIRPDLMKEVVKRFGPELQGIKEKVHGVDLKLNTRYHVIQVHGSKEMRQEVQKMVNELAREKSALGEKPDEIELECPICLSEVDDGYSLEGCSHLFCKACLLEQFEASMRNFDAFPILCSHIDCGAPIVVADMRALLSQEKLDELISASLSAFVTSSDGKLRFCSTPDCPSIYRVAGPQESGEPFICGACHSETCTRCHLEYHPLITCERYKKFKENPDLSLKDWAKGKDVKECPICKSTIEKTDGCNHLQCRCGKHICWTCLDVFTQAEPCYAHLRTIHGGIGLVELGVPEHPVAQPVHRL
What are the official names of this protein?
ATP-dependent RNA helicase DEAH11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y3645_KORVE
Sequence: MTLILNPESARVLGCLIEKEITTPEYYPLSLNALINACNQKSNRDPAMSLDEDSVRVALRNLTDKGLARHAPSEGRVPKYEHDVNNAMQLSRREVAILCELLLRGPQTPGELRGRAERMYKFEGIEDVHSTLQRLMERDPALVVVLPRQPGTKEARYTHTLMPVDMQPQPAVEVSHSVSGGNDGRIAQLEAEVRELRAEIETLKEQVKSLTPVN
What are the official names of this protein?
UPF0502 protein Acid345_3645.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: HEM3_COXBU
Sequence: MIKKRSILIVTRKSPLALWQAEFVKQQIENSHPHLACQILGCTTQGDRLTTEKLVDSGGKDLFVKDLQKALLNRDADIAVHSIKDMSACDGPELMVGAFIRREDPRDVLIVKGELSTLPPHAVIGTSSPRRQCQLKKFQPGCKIKEIRGNVGTRLAKLDAGHYEAIVLAAAGLKRLGLENRIHYYFDPHEFIPAIGQGAIGVECRSDDHEMQTLLKSLDHRETRLCVTAERAVNEKLGGDCFTPIAAHAIIKNDQLSLFAMLGKIDGRVIIRATEIGNSEEAKRIGFKVASQLLEQGGDSLLRELKQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: SIR4_BATDJ
Sequence: MSAQVMHNRVMGTVKDSASKLVDFLMRHHGQTVLLTGAGVSTDSGIPDYRGPQGIYSRNKDFKPIQYQQFVGPHEFRQRYWARSFLGWPKVSQAQPNASHHAIAALESRSHIAGCITQNVDGLHRRAVVIENPNLLEIHGTLHWVNCISCGYKLQRSAMQEQLQKINPIVYEWQRLNPEKSNADVASSLNPDGDVEIKWDYNHFKYPHCPECNGLLKPNVVFFGENMPMTVRDTSFKMIDDAKALLVVGSSLQVYSALRLVKRAASTGKPIAILNLGFTRGDELAQIRINLGSSAVLEELASTIR
What is the function of this protein?
NAD-dependent protein deacylase.  Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
What are the official names of this protein?
NAD-dependent protein deacylase SIR4, Regulatory protein SIR2 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RNAS1_SAGOE
Sequence: MALEKSLALLPLLVLVLLVLGWVQPSLGKESRAQKFQRQHMDSDGSPSSNPTYCNNMMRRRNMTQGRCKPVNTFVHEPLVDVQDVCFQEKVTCKNGQPNCYKSSSSMRITDCRLTNGSRYPNCAYRTSQKERHIIVACEGNPYVPVHFDASVEDST
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPB_ALKMQ
Sequence: MMKVKELPKKFGKFGGQFVPETLMNALIELERQFIQTKEDDEFQEMYRYYVREYSGRPTPLYYAENLTKKLGGGKIYLKREDLNHTGAHKINNVIGQVLLARKMKKKRIIAETGAGQHGVATATICAMFDLECVVYMGAEDIERQALNVFKMEMLGAEVVSVTSGTATLKDATNEAIRDWVANVKDTYYVIGSVVGPHPYPTMVRDFQRIIGDEVKEQILEKEGRLPNYLVACVGGGSNAMGLFYPFYEDEAVALYGVEAAGLGVETDQHAATITKGSMGVIHGMMTYLLQDEQGQITPVHSISAGLDYPGIGPEHAYYHHTGRANYVAITDEEALEAFQLLTRLEGIIPALESAHAIAYLMKLAPKTKGDDIIVLNLSGRGDKDIHTISKLLGGNRDDK
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: EFTS_WOLPP
Sequence: MKMDSSSIRELRDRTGLGLSDCKKALEECDGDIKKAVDRLRTIGFAKADKKSDRVASDGLIAMCLAKNYGVLVKVNCETDFVARNEKFIALVSNLASIACQERCTSLDELKNAKYEDVGTVQEAIISGTSVLGEKLELSNLCYLETKDGIIAGYVHGDMHGLGKIGALVALQSSGDKQEIGKQIAMHVVAMKPEALSIDDLDQEKLNNERSIIEEQVKSLNKPEEVAKKIVDGRMAKYYEEVVLLEQKFIKDDKMKIADFIESSAVKLANYKLLTLDGANK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3GT5_PANPA
Sequence: MAFPKMRLMYVCLLVLGALCLYFSMYSLNLFKEQSFVYKKDGNFLKLPDTDCRQTPPFLVLLVTSSHKQLAERMAIRQTWGKERTVKGKQLKTFFLLGTTSSAAETKEVDQESQRHGDIIQKDFLDGYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMFINVDYLTELLLKKNRTTRFFTGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTGYVFSGDVASQVYNVSESVPYIKLEDVFVGLCLERLNIRLEELHSQPTFFPGGLRFSVCRFRRIVACHFIKPRTLLDYWQALEN
What is the function of this protein?
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure.  Can use glycolipid LC3Cer as an efficient acceptor (By similarity).
What are the official names of this protein?
Beta-1,3-galactosyltransferase 5, Beta-1,3-GalTase 5, Beta3Gal-T5, Beta3GalT5, b3Gal-T5, Beta-3-Gx-T5, UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: RL11_PELUB
Sequence: MAKEISGYIKLQIMGGQANPAPPVGPALGQRGINIMEFCKAFNDKTKAFAGKPIPVVITVYKDKKFDFEIKSPPASHFIKEAAKLKGGSKEPGRSIAGSITKKQAEEIATQKMKDLNAHDLEQAVKIIAGSARSMGIEVKD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MIAB_LYSSC
Sequence: MNEEQRLANQQVNQPKKEDKPEKDYSKYFEKVFTAPSLKDAKKRGKEDVKYHKDFSIDEQFAGMGKDRTFYIRTYGCQMNEHDTEVMAGIFMQLGYTPTEIIEEADVVLLNTCAIRENAENKVFGELGFLLKYKRKNPEMLIGVCGCMSQEESVVNKILRSYPHVDMVFGTHNIHRLPNILKEAYMSKEMVVEVWSKEGDVIENLPKKRLGSIKAWVNIMYGCDKFCTYCIVPYTRGKERSRRPEEIIAEVRELAAAGYQEIMLLGQNVNAYGKDFEDIEYRLGDLMDALRKIDIPRIRFTTSHPRDFDDHLIEVLAKRGNLVEHIHLPVQSGSNDILKIMARKYTREHFLTLVEKIKAAIPEVTLTTDIIVGYPNETEEQFEETLSLYREVGFEAAFTYIYSPREGTPAAKMVDNVPEEVKKERLQRLNEVVGEYSRKALERLNGEVVEVLVEGTSKRRDDVLAGYTRKNRLVNFKGPAEVIGQLVKVKIIETTSYSLTGEFLEVVKNEKVEA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_BRUA4
Sequence: MGGKTVTRADLAEAVYRKVGLSRTESAALVEMILDEVCDAIVNGETVKLSSFATFQVRDKNERIGRNPKTGEEVPILPRRVMTFKASNVLKQRILQEHQKRETKSQK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PURA_LEPIN
Sequence: MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEECDRLQKEGFPVFDKLLLSDACHLLFPYHSQIDSARETTLSQEHKIGTTKKGIGICYADKMMRTGLRVGDLLDTSYQTRLKHLVDEKNRELDKLYGMPPVSYNDINEGLKFFLSKVKKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVTSSNPTTGGALIGTGIPFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEKLRQKGGEFGATTGRPRRCGWFDVEMLKHSVRINGITSIALTKIDILSDYDTIPVATGYKLNGKTLDCFPSQGLDKVEVIYEEFPGWKSDISGICEFQKLPEKCKNYISALEKWIGVKINLVSTGPDRKDTIHGDSF
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REX_LEUCK
Sequence: MTQQPKIPRATAKRLPIYFRYLTFLHDAGTDRISSAELSDAIKFDAATIRRDFSYFGALGKRGYGYDVKALLDFFANVLDQDSLINVALIGAGNLGQALLNFNFHQSSNMRISAAFDVDETRAGTIMAGVPIYAMSELTEQITAQRINIAILTVPQGVAQEITDKLVEAGIKGILNFTPLRVTVPNNVRVQNVDLTNELQTLVYFIDNYGSITTGL
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGIF_RAT
Sequence: AEPVEPWS
What is the function of this protein?
Inhibitor of the proliferation of hepatic stellate cells (HSC).  Also inhibits the growth of bovine endothelial cells and 3T6 fibroblasts.
What are the official names of this protein?
Non-arginase growth inhibitory factor, NAGIF.
Protein: TRMD_WOLSU
Sequence: MKFSFFTLFPSLISGYFEDSILKRARDEGRIEIEWVNFREFSQDRFKKVDEYQIGGGAGLVIEPRVVTQAISELKAKNQDAKILFLLPAGKPFTHQDACRLAQKESHLVLVCGRYEGIDERAIEANADEVFCMGDYILTGGEIAALALCDAVSRQIPGVLGNEESLQGESFDSFLLEAPVFARSKTPEGLSAPSEYSKGNHAKICALKRRLSLAKTQYYRPDLYKKYKIQESDKGKK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_VIBCM
Sequence: MAIKHLFTSESVSEGHPDKIADQISDAVLDAIFEQDPKARVACETYVKTGMVMVGGEITTSAWVDIEEITRQTVREIGYVHSDMGFDANSCAVLNTIGKQSPDINQGVDKADPKEQGAGDQGIMFGYATNETEVLMPAPITYAHRLMQRQAEVRKNGTLPWLRPDAKSQVTFQYDQGKIVGIDAVVLSTQHSDSISTADLREAVMEEIIKPVLPAEWLSKETKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGMADRCEIQLSYAIGVADPTSIMVETFGTEKVSQEIIIEAVRQFFDLRPYGLQEMLNLLQPIYKKTAAYGHFGREEFPWEATDKAALLRDFAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP2A_MOUSE
Sequence: MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK
What is the function of this protein?
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes.  AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.  They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.  AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.  Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation.  Associates with chromatin to the PITX2 P1 promoter region.
What are the official names of this protein?
Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2.
What is the protein family that this protein belongs to?
Belongs to the AP-2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADK_ZYMMO
Sequence: MKFNRMTLIASPTPKAQKAAEELKKLYQWYPLEEADVIIALGGDGFMLQTLHHLLDNSFNLPVFGMNLGTVGFLMNEWRPSNLLRRLIRAKQFTVYPLRMDGQTVSGEQKIYRAINEVSMLRETRQTAHLEISVDGRIVLPELVSDGVLVATPAGSTAYNLSADGPILPFDSGMLALTPISPFRPRRWRGAIVPDGSIIDMRVVDPDKRPMSAVADQRELREIANVTITLDRTTPLHLLFDPNHALDDRIAREQFRLC
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG2_BRUSU
Sequence: MKKIPRIGVGGPVGSGKMAIIEAVVPILIKLGYRILVITNDIVTTEDAKHVQRTLKGVLIEDRIVGVETGGCPHTAVREDPSMNLAAVEEMEAKFPDTDLVLLESGGDNLTLTFSPALIDFFIYVIDVAAGDKIPCKNGPGISQSDILVINKTDLAPYVGASLQVMDDDSRMMRGKKPFVFTNCKTNEGIDDLVHLIRENVLFDTEVSKESA
What is the function of this protein?
Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
What are the official names of this protein?
Urease accessory protein UreG 2.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPOP_HUMAN
Sequence: MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
What is the function of this protein?
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.  In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.  In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation.  Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.  The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.  Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420).
What are the official names of this protein?
Speckle-type POZ protein, HIB homolog 1, Roadkill homolog 1.
What is the protein family that this protein belongs to?
Belongs to the Tdpoz family.