PharMolix/UniProtQA huggingface dataset:
Protein: DTD_DICTD
Sequence: MRAVIQRVKKASVKVNGELISQISQGLLIFLGISKKDKEEDIKILADKIADLRIFSDENGKMNLSIKEVNGDILVVSQFTLFADCRRGKRPDFTDAADKEKALDYYKKFVAYLKNKSEKVEEGIFQAYMEVELINDGPVTIILDTEDLKKPRRRKE
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAX2G_CENTE
Sequence: TIINVKCTSPKQCLKPCKDLYGPHAGEKCMNGKCKCYKI
What is the function of this protein?
Blocks human voltage-gated potassium channels Kv1. 2/KCNA2 (IC(50)=0. 7 nM), Kv1. 3/KCNA3 (IC(50)=26. 2 nM) and blocks intermediate conductance calcium-activated potassium channel KCa3. 1/KCNN4 (IC(50)=56 nM).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 2.16, Toxin II.12.5.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 02 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ASTRA_MOUSE
Sequence: MFDTTPHSGRSSPSSSPSLRKRLQLLPPIRPPPASEPEPGTMVEKGSDSSSEKSGVSGTLSTQSLGSRNFIRNSKKMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNGLGSPKEVGDVIALSDISPSGAADHSQEPSPVGSRRGRVTPNLSRASSDADHGAEEDKEEQTDGLDASSSQTVTPVAEPLSSEPTPPDGPTSSLGPLDLLSREELLTDTSNSSSSTGEEGDLAALLPDLSGRLLINSVFHMGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLDRELAKAEKLSLEEGGKDTRGLLSGLRRRKRPLSWRGHRDGPQHPDPDPCTQTSMHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLIVLIALNALLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVPDPPLDTQPQPDDSFP
What is the function of this protein?
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461).  Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461).  Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461).  In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461).  At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461).  May play a role in tumor progression (PubMed:27585821).  Plays a role in autophagy regulation and is required for biogenesis of the autophagosome.  This function in autophagy requires its cholesterol-transfer activity (By similarity).
What are the official names of this protein?
Protein Aster-A, GRAM domain-containing protein 1A.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, autophagosome. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:30220461). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (By similarity).
Protein: MIAA_LISIN
Sequence: MSKIPVIVIVGPTAVGKTSLSITLAKNFDGEIISGDSMQVYRGLDIGTAKITPEEMDGIKHYLIDVTDPAVPFTAAKFQAETRGLIESIHNRGKLPIIVGGTGLYIQSVFYDYGFGNASEDKAYRRELDQLDKTTLWQMLDQLDPKSAELIHENNKRRVIRALEVIHLTGKPFSEYQVHHTLNEAYQPLFLGLDLDRELLYERINRRVELMFEEGLVSEASKLYDEHLVDVPAIRGIGYKELFTYFDGNSSLEEAKELIQKNSRHFAKRQLTWFRNRMDIDWIQAGVSTTDTEAMEKVKTFLASK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: UBIG_XANC5
Sequence: MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSTRLELAGARVLDVGCGGGLLSESMARLGAQVTAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQPGSFDTVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLNRTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: RL27_GLUOX
Sequence: MAQKKAGGSSRNGRDSAGRRLGVKKFGGESVIAGNIIVRQRGTKMKAGANVGIGRDHTLFALVDGHVKFQRRAEGRVHVSVALPEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: UKL3_ARATH
Sequence: MASKSDVNIIETSSKVHFSGFHQMDGLASNRPEQMAEEEEHGQPFVIGVAGGAASGKTTVCDMIMQQLHDQRAVVVNQDSFYHNVNEVELVRVHDYNFDHPDAFDTEQLLSSMEKLRKGQAVDIPNYDFKSYKNNVFPPRRVNPSDVIILEGILIFHDPRVRDLMNMKIFVDADADVRLARRIKRDTVEKGRDIATVLDQYSKFVKPAFEDFILPTKKYADIIIPRGGDNHVAIDLIVQHIHTKLGQHDLCKIYPNLYVIQSTFQIRGMHTLIRDSKTTKHDFIFYSDRLIRLVVEHGLGHLPFTEKQVVTPTGSVYSGVDFCKKLCGVSVIRSGESMENALRACCKGIKIGKILIHREGDNGQQLIYEKLPSDISERHVLLLDPILGTGNSAVQAIRLLISKGVPESNIIFLNLISAPEGVNVVCKKFPRIKIVTSEIELGLNDEFRVVPGMGEFGDRYFGTDDE
What is the function of this protein?
Involved in the pyrimidine salvage pathway.  The uracil phosphoribosyltransferase (UPRT) activity, that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate, is unsure.
What are the official names of this protein?
Uridine kinase-like protein 3.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPRTase family.
Protein: YCHN_ECO57
Sequence: MQKIVIVANGAPYGSESLFNSLRLAIALREQESNLDLRLFLMSDAVTAGLRGQKPGEGYNIQQMLEILTAQNVPVKLCKTCTDGRGISTLPLIDGVEIGTLVELAQWTLSADKVLTF
What are the official names of this protein?
Protein YchN.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0989.
Protein: NIP11_ARATH
Sequence: MADISGNGYGNAREEVVMVNLKDEVEHQQEMEDIHNPRPLKKQDSLLSVSVPFLQKLIAEFLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVGSDLQAFTMEFIVTFYLMFIISGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPALVYGCYKGIWIYLVAPTLGAIAGAWVYNTVRYTDKPLREITKSGSFLKTVRIGST
What is the function of this protein?
Water channel probably required to promote glycerol permeability and water transport across cell membranes.
What are the official names of this protein?
Aquaporin NIP1-1, NOD26-like intrinsic protein 1-1, AtNIP1;1, Nodulin-26-like major intrinsic protein 1, NodLikeMip1, Protein NLM1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BIOF_ECOK1
Sequence: MIWQEKIDAALDARRVADALRRRYPVAQGAGRWLVADDCQYLNFSSNDYLGLSHHPQIIRAWQQGADQFGVGSGGSGHVSGYSVAHQVLEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIVADRLSHASLLEAASLSPSPLRRFAHNDVTHLARLLASPCPGQQLVVTEGVFSMDGDSAPLEEIQQVTQQHDGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSNTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLAGSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: QCR2_ASHGO
Sequence: MLSQRLQCSKQFARHLSVAAKDGSGKVSTLSVQVQGGSRYATKDGVAHLLSRFNFHNTGNKSALRLVRESELLGGRFQSTVDREHITLSATFLKEDLPYFVNALADVLYKTSFRPHELAESVLPAATRDAAVARACPVAAAEEALYSVTYRHGLGKPVLYDGVEKVTLEDIKAYADKVYTKENVTVLGQGINEADLKRFVNDSLLASLPSGTSLAGSGNAKTHSGEARLRHAGSSVAAIAVPVAKADFATYEVLARYLTSDLYALSPLVHKAKLDKYTDGGLFSLYVKSAEAAKAAADIKKVVADLKAGKDISVARKYAALQLAVENDSAASPVSLKLENAKDFKLGKFNYVAVGDVSNLPFADEL
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 2, mitochondrial, Complex III subunit 2, Core protein II, Ubiquinol-cytochrome-c reductase complex core protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: S12A1_HUMAN
Sequence: MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
What is the function of this protein?
Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation.  Electrically silent transporter system.
What are the official names of this protein?
Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: CRCB_DESVH
Sequence: MHRFVLVATGGIFGSLARYVLSGVAQKLTTSSFPYGTVLVNLLGSLLFGLVWGILENRITFAPEARLLLLTGFMGSLTTFSTLTYEGMVLLQSHMWLQAALYIVGQTVAGIMLVWFGAGLGRLV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SURA_HAHCH
Sequence: MKTLRLNFRSAILKALGALLLLQGCLAHAQVQELDRVVAVVNDDIVLYSELQDRASRIKDKLRQQKTPLPPEAVLHEKVLDQLVLESIQMQMADRGGIRVSDSQLNQTMQNIAKQNGMTLDQFQQALSEEGVTYQSAREQIRREMIISRVQQRSVDSRVRVTEKEVNDFLKSASAKEQRAEEYHLAHILIALPENPSDAQRKEAESKVEKIRSQLDQGVDFKQLAITYSDASTATQGGDLGWRKPDQVPSLFADVAPKLAPGQTSEPIRNSSGVHFVAMLEKRGGVSKVVEQSKVRHILVQQNELRDEIAAKKLIEEIYGKVQAGEDFAELAKAYSDDAVSAAAGGSLDWVNPGDMVPEFDQMMRETPVGAVSKPFQSTFGWHILQVQDRREADIGDRLMASQARQVLHRRKYEEELQNWLSEIRDEAFVQLKL
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: ARCA_BORBZ
Sequence: MEEEYLNPINIFSEIGRLKKVLLHRPGEELENLTPLIMKNFLFDDIPYLKVARQEHEVFVNILKDNSVEIEYVEDLVSEVLASSVALKNKFISQFILEAEIKTDGVINILKDYFSNLTVDNMVSKMISGVAREELKDCEFSLDDWVNGSSLFVIDPMPNVLFTRDPFASIGNGITINKMYTKVRRRETIFAEYIFKYHSAYKENVPIWFNRWEETSLEGGDEFVLNKDLLVIGISERTEAGSVEKLAASLFKNKAPFSTILAFKIPKNRAYMHLDTVFTQIDYSVFTSFTSDDMYFSIYVLTYNSNSNKINIKKEKAKLKDVLSFYLGRKIDIIKCAGGDLIHGAREQWNDGANVLAIAPGEVIAYSRNHVTNKLFEENGIKVHRIPSSELSRGRGGPRCMSMSLVREDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_STRP7
Sequence: MAQIKITLTKSPIGRIPSQRKTVVALGLGKLNSSVIKEDNAAIRGMITAVSHLVTVEEVN
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: PSIA2_ECOLX
Sequence: MSARSQALVPLSAEQQAAWRAVAETEKRRHQGNTLAEYPYAGAFFRCLNGSRRISLSDLRFFMPSLTAEELRGNRSQWLYAVDVLIETQGEVCLLPLPGDAAERLFPSVRFRVRERSRHKSALVMQKYSRQQAREAEQKARAYQALVAQAEIELAFHSPETVGSWHARWSDRVAEHDLETLFWQWGERFPSLAGMERWQWQDMPFWQVIAERSLAAREAGHAVREMERWMVPNKLREAA
What is the function of this protein?
Not yet known.
What are the official names of this protein?
Protein PsiA.
What is the protein family that this protein belongs to?
To PsiA protein of plasmid F.
Protein: NUSB_GLUOX
Sequence: MTVTDAPSANPTRRSRTIARVAAVQALFQCEQSGDTAETVISQFIRHRRISSTASFDDGHIPDADLKLFQEIVLGVTRRQDDIDAKLSDVLPEQWPLPRLDPVLRALLRAAVFEIGTDTPDRIIINEYLDVAHGFFSGDEPKMVNGILDTLSRRANDGNV
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PGK_HALVA
Sequence: MMTFQTLDDLDDGQRVLVRLDLNSPVEDGTVQDNRRFDRHAETVKELADRGFEVAVLAHQGRPGRDDFVSLDQHADILADHIDRDVDFVDETYGPQAIHDIADLDSGDVLVLENTRMCDDELPEEDPEVKAQTEFVKTLAGEFDAYINDAYSAAHRSHASLVGFPLVMDAYAGRVMETEYEANTAIAEKEFDGQVTMVVGGTKATDVIDVMTHLDEKVDDFLLGGIAGTVPAAAGHPVGYDIDDANLYDEQWEANSEKIESMLEDHRDQITLAVDLAYEDENDDRAEQAVDDIDEKRLSYLDVGSETLMEYSPIIRESEAVFGEGRAGMFEDERFSVGTAGVLEAIADTDCFSVVGGGDTSRAIEMYGMEEDEFGHVSIAGGAYIRALTRAQLVGVEVLQR
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA3_ORYSJ
Sequence: MSSIGTGYDLSVTTFSPDGRVFQVEYATKAVDNSGTVVGIKCKDGIVLGVEKLVTSKMMLEGSNRRIHSVHWHSGLAVAGLAADGRQIVSRAKSEAASYEKVYGEPISVKELADRVASYVHLCTLYWWLRPFGCGVILGGYDRDGPQLYMIEPSGVSYKYFGAALGKGRQAAKTEIEKLKLSELTCREGIVEVAKIIYGVHDEAKDKAFELELSWICDESNRQHQKVPADLLEQAKVAAQAALEEMDAD
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-3, 20S proteasome alpha subunit G, 20S proteasome subunit alpha-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EDEM2_MOUSE
Sequence: MPFRLLIPLGLVCVLLPLHHGAPGPDGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSLKQSRPKRAQRKTVRSGPWEPQSGPATLSSPANQPREKQPAQQRTPLLSCPSQPFTSKLALLGQVFLDSS
What is the function of this protein?
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15579471, PubMed:25655076).  May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (By similarity).  Seems to recognize and bind to exposed hydrophobic regions in target proteins (PubMed:25655076).
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PANC_VESOH
Sequence: MKLCYQNIQITELVNDWHEQEKTIAFIPTMGGLHQGHLSLIDIAKQKADKVVVSIFVNPAQFDKNEDLDSYPRSLNADLVELEENVDSVFVPDVKQIYPNGISKYIDVGMIGRILCGKTRPHFFNGMIQVVEILFEIVRPNVAIFGQKDYQQLLVIKQMVKNLSLDICIESGEIIREKSGLAMSTRNQYLSENDAKIAANLYRILTYVKHEVLQNKKIDVLKKMAESDLKQHFKLDYLEVLDANTLKQITDNTCQIIILSAVFLGSVRLIDNIIFLKKDNYV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_CHESB
Sequence: MLKGATLIAGPTASGKSALALQMARERDGVIVNADSMQVYSVLHLLTARPGPEELAMAPHRLYGHVPPSKPYSTGRWISDVRELIEAEALARRAVIFVGGTGLYFRALTEGLSPMPEIPEAVRIRWRKRLAEEGGEALHRLLGEADPLAASRIRPSDSQRIVRALEVVEASGRPISYWQGQASHPLVDMTSCRKIVLMPDRNTLASRIEKRFDQMLRHGAVEEVKQLLALDLPPSMPAMKAIGVREISAVLAGEISLDEAGSRAIAATRQYAKRQITWFRHQLGPDWEHMPV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RS5_STAMF
Sequence: MPMSAIDKEALETWVPRTRVGKMVVEGKITSLKEIFDRNLPLLEPEIVDYLLPDLKYERLDVGIVQKVTDAGRRSRFRVVVVVGNEDGFVGVGSGKARQYLVALRKALRNAKLNITPVRRGCGSWECRCGEPHSIPFTVQGKSGSVVVVLKPAPKGTGLVAGDTAKAVLRMAGIKDVWTETFGKTKTTLNFAKAVVNALRNTYKFVAPVDWLKA
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: GH_HHV1E
Sequence: MGNGLWFVGVIILGAAWGQVHDWTEQTDPWFLDGLGMDRMYWRDTNTGRLWLPNTPDPQKPPRGFLAPPDELNLTTASLPLLRWYEERFCFVLVTTAEFPRDPGQLLYIPKTYLLGRPPNASLPAPTTVEPTAQPPPAVAPLKGLLHNPTASVLLRSRAWVTFSAVPDPEALTFPRGDNVATASHPSGPRDTPPPRPPVGARRHPTTELDITHLHNASTTWLATRGLLRSPGRYVYFSPSASTWPVGIWTTGELVLGCDAALVRARYGREFMGLVISMHDSPPAEVMVVPAGQTLDRVGDPADENPPGALPGPPGGPRYRVFVLGSLTRADNGSALDALRRVGGYPEEGTNYAQFLSRAYAEFFSGDAGAEQGPRPPLFWRLTGLLATSGFAFVNAAHANGAVCLSDLLGFLAHSRALAGLAARGAAGCAADSVFFNVSVLDPTARLQLEARLQHLVAEILEREQSLALHALGYQLAFVLDSPSAYDAVAPSAAHLIDALYAEFLGGRVLTTPVVHRALFYASAVLRQPFLAGVPSAVQRERARRSLLIASALCTSDVAAATNADLRTALARADHQKTLFWLPDHFSPCAASLRFDLDESVFILDALAQATRSETPVEVLAQQTHGLASTLTRWAHYNALIRAFVPEASHRCGGQSANVEPRILVPITHNASYVVTHSPLPRGIGYKLTGVDVRRPLFLTYLTATCEGSTRDIESKRLVRTQNQRDLGLVGAVFMRYTPAGEVMSVLLVDTDNTQQQIAAGPTEGAPSVFSSDVPSTALLLFPNGTVIHLLAFDTQPVAAIAPGFLAASALGVVMITAALAGILKVLRTSVPFFWRRE
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: YBEY_BACLD
Sequence: MSLILDITDETGRVPEDRLAEIEKLLQFAAAEEGVADGAEVSVTIVNNEEIQKINKEYRGKDYPTDVISFALEEDGEGEVEIIGADMPPVLGDIIISVDKAREQAEEYGHSLMRELGFLTVHGFLHLLGYDHMTEEEEKEMFTKQKEILNRYGLSRSS
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.