PharMolix/UniProtQA huggingface dataset:
Protein: MNN9_YEAST
Sequence: MSLSLVSYRLRKNPWVNIFLPVLAIFLIYIIFFQRDQSLLGLNGQSISQHKWAHEKENTFYFPFTKKYKMPKYSYKKKSGWLFNDHVEDIIPEGHIAHYDLNKLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLALKKLENAIKKVQTDKKTQRFSKITILRQNSQSFDKLMEKERHALDVQKERRAAMALARNELLFSTIGPHTSWVLWLDADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSIRPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALDGVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEEENH
What is the function of this protein?
The M-Pol I and M-Pol II complexes possess alpha-1,6-mannosyltransferase activity and are probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.  May also provide alpha-1,2-mannosyltransferase activity to the M-Pol I complex.
What are the official names of this protein?
Mannan polymerase complexes subunit MNN9, M-pol I subunit MNN9, M-Pol II subunit MNN9.
What is the protein family that this protein belongs to?
Belongs to the ANP1/MMN9/VAN1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Cis-Golgi (PubMed:9430634). Recycles between endoplasmic reticulum and Golgi (PubMed:11095735).
Protein: ARFA_ECOLI
Sequence: MSRYQHTKGQIKDNAIEALLHDPLFRQRVEKNKKGKGSYMRKGKHGNRGNWEASGKKVNHFFTTGLLLSGAC
What is the function of this protein?
Rescues ribosomes stalled at the 3' end of non-stop mRNAs (PubMed:21062370, PubMed:21435036).  This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system (PubMed:21062370, PubMed:21435036).  Binds the 30S subunit, contacting 16S rRNA with the N-terminus near the decoding center and its C-terminus in the mRNA entry channel; contacts change in the presence of release factor 2 (RF2, also named PrfB) (PubMed:25355516, PubMed:27906160, PubMed:27906161, PubMed:27934701, PubMed:28077875).  Requires RF2/PrfB to hydrolyze stalled peptidyl-tRNA on the ribosome; recruits and probably helps position RF2/PrfB correctly in the ribosomal A site so RF2's GGQ motif can hydrolyze the peptidyl-tRNA bond (PubMed:22857598, PubMed:22922063, PubMed:25355516, PubMed:27906160, PubMed:27906161, PubMed:27934701, PubMed:28077875).  Does not release ribosomes with a programmed pause caused by regulatory chains such as SecM-mediated pausing (PubMed:22857598).  Binds tRNA which may stimulate its ribosome rescue activity (PubMed:22857598).
What are the official names of this protein?
Alternative ribosome-rescue factor A.
What is the protein family that this protein belongs to?
Belongs to the alternative ribosome-rescue factor A family.
Protein: RPOB_STAA2
Sequence: MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYEWFLREGLIEMFRDISPIEDFTGNLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFMGDFPLMTDTGTFVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVVYVRIDRTRKLPLTVLLRALGFSSDQEIVDLLGDNEYLRNTLEKDGTENTEQALLEIYERLRPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKTNKKLHLKHRLFNQKLAEPIVNTETGEIVVEEGTVLDRRKIDEIMDVLESNANSEVFELHGSVIDEPVEIQSIKVYVPNDDEGRTTTVIGNAFPDSEVKCITPADIIASMSYFFNLLSGIGYTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTESITPQQLINIRPVIASIKEFFGSSQLSQFMDQANPLAELTHKRRLSALGPGGLTRERAQMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYARVNEFGFIETPYRKVDLDTHAITDQIDYLTADEEDSYVVAQANSKLDENGRFMDDEVVCRFRGNNTVMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNPEAPFVGTGMEHVAARDSGAAITAKHRGRVEHVESNEILVRRLVEENGVEHEGELDRYPLAKFKRSNSGTCYNQRPIVAVGDVVEYNEILADGPSMELGEMALGRNVVVGFMTWDGYNYEDAVIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVSESALKNLDDRGIVYIGAEVKDGDILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDDTLSPGVNQLVRVYIVQKRKIHVGDKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNPLGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYDGRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDTVGRVKTYEAIVKGENISRPSVPESFRVLMKELQSLGLDVKVMDEQDNEIEMTDVDDDDVVERKVDLQQNDAPETQKEVTD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CC172_HUMAN
Sequence: MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK
What are the official names of this protein?
Coiled-coil domain-containing protein 172.
What is the protein family that this protein belongs to?
Belongs to the CCDC172 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Note=In spermatozoa, localized in the middle piece, predominantly concentrated at the mitochondrial sheath of the flagella and to a lesser extent with outer dense fibers (ODF) (By similarity). Colocalized with TEKT2 at the perinuclear region (By similarity).
Protein: UBC9_RAT
Sequence: MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
What is the function of this protein?
Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity).  Can catalyze the formation of poly-SUMO chains (By similarity).  Essential for nuclear architecture and chromosome segregation (By similarity).  Necessary for sumoylation of FOXL2 and KAT5 (By similarity).  Sumoylates p53/TP53 at 'Lys-386' (By similarity).  Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By similarity).
What are the official names of this protein?
SUMO-conjugating enzyme UBC9, RING-type E3 SUMO transferase UBC9, SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-conjugating enzyme UbcE2A, Ubiquitin-protein ligase I.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (By similarity). Recruited by BCL11A into the nuclear body (By similarity).
Protein: SORT1_DANRE
Sequence: MSTVLCCVLVLLISVALCMDFEERPSSSWRSEQTMFLKSHKSRNLLSLRDLQQPDHGKMKRSEESAQNQCESLHGYQSTLQNDTHTHNFNDLSGSVSLAWVGDGTGVLLVLTTFQVPLFIMRFGQSKLYRSEDYGKTFQDITDLINNTFIQTEFGIAIGPDNSGKVILTGDLAEGKVTKIFRSVDFGKSFVTSELPFHPLMQITYNPKDSNILMVYSINYDLWLSKDFGANWKKIHESVCLVKWGIDDTIFLTTNPNGSCSDRGTLELRKSLDYGKTFKTIGNRIYSFGLGGRFVFASIMTDSGSTRMIHVSVDQGETWDMAQLPTVGHEQFYSILAANNDMVFMHVDEPGDSGIGTIYISDDRGIVFSKSLERHLYTTTGGDTDFTNITSLRGVYITSVLAEDGSVQTVITFNQGGEWRPLMKPWNGVCDSTAKHPSECSLHIHASYSISMKLNVPMQPLSETNAVGLVLAHGSVGGAVSVLSPDVYVSDDGGYTWFQALKGPHHYAILDSGGLLVAVEHNPTHPISQIKFSTDEGQCWHAHNFTDDPIYFTGLASEPGARSMNVSLWGYRDTILNQYWVSVTVDFRQLLSRDCQENDYIQWLAHSSDINSPTDGCVLGYKERFLRLRRDSVCWNGRDYKVTKEPTTCPCTLTDFHDFGFYHEENSSVCVEQPDLIGHSLEFCLHGRKEQLQTSGYRKIPGDHCEEGITPERKEIDLSKKCVSNLLRTEQLTKEHSFNSAPIIAVVIIVLLISAVAGVIFIKKYVCGGRFLVHRYSVLQQHAEANGIDGLDDLDTLEGGKTHYHDDSDEDLLE
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.  Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR).  Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.  The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.  Also required for protein transport from the Golgi apparatus to the endosomes.  May also mediate transport from the endoplasmic reticulum to the Golgi.
What are the official names of this protein?
Sortilin.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family. SORT1 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane; Single-pass type I membrane protein.
Protein: KTHY_SHIFL
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA
What is the function of this protein?
Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor.  Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth (By similarity).
What are the official names of this protein?
Thymidylate kinase, Thymidine monophosphate kinase, dTMP kinase, TMPK.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: EFP_BLOFL
Sequence: MLYNINELKVGLKVIQNKEPYVIIKNECIKPGKGQSFNRVRFKQIKSGKILEKTLKPGDLVESANIVETELIYVYRDRDLWFFMNRDSFDQISVHFDILGKSVKWMVEQLVYVVVFWDNNPILVIPPEFIKLKIIKTNLITKNISTASGNKLAVVSTGAVVKVPFFIQSGELIKVNTHSGSYISRIK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-33 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITGL_AGRIP
Sequence: MHRTMAVTAVLVLSAAGAAHAWGGLFNRFSSDMLANLGYGRSPYRHYPYGQEPEEVYAEALEGNRLDDVIDEPGHCYSAPCTTNGDCCRGLLCLDTEDGGRCLPAFAGRKLGEICNRENQCDAGLVCEEVVPGEMHVCRPPTAGRKQYNEDCNSSSECDVTRGLCCIMQRRHRQKPRKSCGYFKEPLVCIGPVATDQIREFVQHTAGEKRIGVYRLH
What are the official names of this protein?
ITG-like peptide.
What are the subcellular locations of this protein?
Secreted.
Protein: RL17_SHEB8
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTVAKAKELRRVVEPLITLAKSDSVANRRLAFARTRDAEVVGKLFTELGPRYQERPGGYTRILKCGLRAGDKAPMAYIELVGRPEAAQAVDVEAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SH3B4_MOUSE
Sequence: MAAQRIRAANASGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPEEVAKELDLLGGGWTDDQKESGRPYSNNPFWNGVRTNPFLNGNAQPSTDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGLQVEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPVPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSVSPVVEVKLSNLEVSTFIILEMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYVPIPLAYSYGDTIQVQLDNLEPCMYLAIVAQGPNILYPSTVWDFINKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYEVKANEQARVVRGFQMKLGKVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI
What is the function of this protein?
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.  Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes.  Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation.  Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
What are the official names of this protein?
SH3 domain-binding protein 4.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor- containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity).
Protein: TRUB_BUCBP
Sequence: MYSEFRSIDGIILIDKPYGLSSHETLQKVKGILKIKKMGHTGTLDPLATGMLPMCCGRATKFSQFLMNFKKRYRVIAKLGQKTSTSDSEGQIIHVRPITFTNLQLQKVLKSFHGKIKQIPSMYSAIKYHGHALYKYARQGIVISRKVRDAIIYELKVLGYSYKHKYLELDIICSKGTYIRTLIEDVGEKLNCGAHVISLRRLQVGNYTSFQMIDIKTLNKLVKYNINVLEHILLSVDNAISCFPEVNIVPNVIKNLQNGQKVKTHSGFINQFVRITEGINRRFIGIGKINNINELYSYRLII
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RL30_FRATO
Sequence: MTQAKTFKVTLVKSLIGRKENHIASARGLGLRKINHTVEVLDTPENRGMANKIYYMVKIEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: YBEY_RHOE4
Sequence: MSIEVSNESGMDISEPELISVARFVIARMDVHPAAELSMVLVDSATMADLHVRWMDLPGPTDVMSFPMDELEPGGRPDSPEPGPSMLGDIVLCPSFAADQADKAGHSLAHELALLTVHGVLHLLGYDHAEPEEEKEMFGLQNSLLEEWYEDLRRIDREAALAERDQKLLGKTGFVDGVDR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPSN_HUMAN
Sequence: MKSLSLLLAVALGLATAVSAGPAVIECWFVEDASGKGLAKRPGALLLRQGPGEPPPRPDLDPELYLSVHDPAGALQAAFRRYPRGAPAPHCEMSRFVPLPASAKWASGLTPAQNCPRALDGAWLMVSISSPVLSLSSLLRPQPEPQQEPVLITMATVVLTVLTHTPAPRVRLGQDALLDLSFAYMPPTSEAASSLAPGPPPFGLEWRRQHLGKGHLLLAATPGLNGQMPAAQEGAVAFAAWDDDEPWGPWTGNGTFWLPTVQPFQEGTYLATIHLPYLQGQVTLELAVYKPPKVSLMPATLARAAPGEAPPELLCLVSHFYPSGGLEVEWELRGGPGGRSQKAEGQRWLSALRHHSDGSVSLSGHLQPPPVTTEQHGARYACRIHHPSLPASGRSAEVTLEVAGLSGPSLEDSVGLFLSAFLLLGLFKALGWAAVYLSTCKDSKKKAE
What is the function of this protein?
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
What are the official names of this protein?
Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: STXA_SYNHO
Sequence: MSSDLVMPALGRPFTLGMLYDARREKLIPGFSLFGDETLQKYQSSNAQRSSEFKIVASDSTESKSSAMDIEASLGVSFLGGLVEVGGSAKYLNNTKKYQNQSRVTLKYKATTVYKQFTAPPGTVTVQETAITEKGLATHVVTSILYGANAFFVSDSDKVEDTNLQDIQGKMEAAIKKIPTISIEGSASVQLTDEEKSLASNLSCKFHGDFLLESLPTTFEDAVKTYQTLPTLIGEDGANSVPMKVWLAPLKSYNSKAQQLIQEINVSKVRRIHTTLEELHKLKRRANEAMDVKLVQRIPLIHDKISNFQQIFQDYMLTVQKKIAEKLPLVRAGTESEQSLQKIIDDRAQSPFSNEKVSKWLDAVEREIAVLKSCAGMVEGTQAKFVSNQTELDREVLVGKVKHAVCFIFTSVERNDPYLKVLSDYWESPPSNNAKDVAPSTEDKWCFSTEVVLKMQQRAQTFCDHVNDFEKSRNVGFFITALENGKFQGASIYYYKEGSLATQDFTFPRMPFVQGYKKRSDLLWYACDLTFDRNTINNWISLSDNDTFAASEHGKRQNYPKHPERFVSFNQVLCNEGLMGKHYWEVEWNGYIDVGIAYISIPRKEIDFASAFGYNTYSWVLSYNPKIGYIERHKKREYNVRAPNPGFKRLGLFLDWRYGSISFYAVSSDEVHHLHTFKTKFTEPVYPAFSIGPAGNHGTLRLL
What is the function of this protein?
This lethal (towards mammals) heterodimer induces hemolytic activities due to its ability to form pores in the cell membrane (PubMed:1790672, PubMed:9271089, PubMed:12177053, PubMed:26627714).  The pore may be composed of 10 SNTX-alpha/beta heterodimers (PubMed:26627714).  The toxin elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels (PubMed:8310447, PubMed:11931843).  In addition, it displays edema-inducing activities, increases vascular permeability.  It also shows myotoxic activities and interferes irreversibly with neuromuscular function (PubMed:8079369).  It also induces irreversible platelet aggregation in rabbit or rat (but not in human or mouse) whole blood (PubMed:8533137).  In addition, it has been observed to increase spontaneous quantal acetylcholine release from isolated frog cutaneous pectoris motor endings (PubMed:8921306).
What are the official names of this protein?
Stonustoxin subunit alpha, SNTX subunit alpha, DELTA-synanceitoxin-Sh1a, DELTA-SYTX-Sh1a, Trachynilysin subunit alpha, TLY subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the SNTX/VTX toxin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the venom gland lumen (PubMed:8810331). The secretion is proved by the fact that the complete sequence shown in this entry is found in the venom gland's lumen, although no signal peptide has been found (PubMed:8810331). This protein may follow a novel secretion pathway (PubMed:8810331). It has been reported that venom-secreting cells of stonefishes do not possess Golgi apparatus and rough endoplasmic reticulum (PubMed:8810331).
Protein: DPHB_METS5
Sequence: MADIYFVGLGLSKRFLTNASLEVLKGSDVIYADIYTSISCDINEKTLREITGKEIIPATREVLETKEKEIYKLLDSGKNVAIAVVGDPMIATTHVSLATGARARGHRVSVIPGVSVHCYMISRSMLSSYKFGKSVTVTFPVLDKLDYTPYRVIKTNRELGLHTMVYLDLKETGIMTADLALNYLKKMESDIGDKVILDDDLVVIGERLGCADERVRAMKVVDALNQKFGAPPHIIIVPSRNLYEMEVEGLKCLS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: RL10_METNO
Sequence: MDRAAKADLVATLNGVFSTTSLVVVAHYKGLTVADMQKLRSQMKQAGATVKVAKNRLANIALDGTDVASIKPLLKGPTLLAYSSDPVAAAKVAVDFAKANDKLVILGGAMGATALNPDGVKALATLPSLDELRAKIVGLVQAPATKIAQVVNAPAAKLARVFGAYADSAKTDEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SYFA_RHILO
Sequence: MNDATSGLDTLENSLLADIASAADEPAIEAVRIAAFGKKGTVSEMLKTLGAMTAEERQLKGPVINGLKNRVTEALTARKAELKDVAIAARLAAEKVDVTLPVRQSPAERGRIHPISQVIDEIAAIFGDLGFAIAEGPDIETDYYNFTALNFPEGHPAREMHDTFFFQPDEKGERKLLRTHTSPVQIRTMEKQKPPIRIVIPGKTYRQDSDATHSPMFHQVEGLVIDKTANVANMKWVLEEFCKAFFEVPSVKMRFRPSFFPFTEPSLEVDIQCDRSRPGEVRFGEGSDWMEILGCGMVHPNVLRAGGLDPDEYQGFAWGMGIDRIAMLKYGMPDLRAFFDADVRWLSHYGFRPLDMPTLFGGLSA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YB89_SCHPO
Sequence: MEQVIQNNCSEVDPHVLSYCTGYANDAIKDVDEASDHTISLIRNLLLDAGAREEAVQLIQNELEKQFKEREEHLDTLQTNGLVRLKETIRMDSQSEISSTMGLVGEKMELDAVKGRKVESRVDRRKLEKAERKIRAKWEKRTIKAEYESSKLVQPEQKSYEEFYMAVNPLDLSGSNQGKSKDIKIDGIDLAFAGHRILTGASLTLAQGRRYGLTGRNGIGKSTLLRALSRREIAIPTHITILHVEQEMTGDDTPALQSVLDADVWRKYLIQDQEKITNRLSTIEKELEELSKDQTADQAISRRLERERDELDLRLLDIQNKLSEMDSDRAESRAATILAGLGFTQEMQSHATKTFSGGWRMRLSLARALFCQPDLLLLDEPSNMLDVPSIAFLSEYLQTYKNIVLVVSHDRSFLNEVATDIIHQHSERLDYYKGNFSQFYATREERCKNQLREYEKQMEYRKHLQSFIDKFRYNAAKSSEAQSRIKKLEKLPILEKPQTEEEVEFEFPPVEKISPPILQMSDVNFEYVPGHPILKHVDIDVQMDSRIGVVGPNGAGKSTMLKLLIEQLHPTSGIVSRHPRLRIAYFAQHHVDTLDLNLNALSFLAKTFPGKGEEEYRRHLGAFGVSGPLALQKMITLSGGQKSRVAFACLGLQNPHILILDEPTNHLDMESMDALTRAVKRFQGGVILVSHDVDFLDKTCTSIWQCDHNVVSKFDGTISQYKKFCLSQQPTMTIKT
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein C29A3.09c.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP5_ROTH6
Sequence: MSLSIDVTSLPSISSSIYKHESSSTTSTISGKSIGRSEQYISPDAEAFNKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSDIGCDQVDFSLNRGIKIDAMVDSSISISTKSKKEKSKHETKNRKCYPKIEAESDSDDYVLDDSDSDDGKCKNCKYKKKYFALRLRMKQVAMQLIENL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: ILVC2_SACS2
Sequence: MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIPDEVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPKSVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARLIAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGYPVFYRLWELATQSEMAKAEKELYKLLGRKVKND
What are the official names of this protein?
Putative ketol-acid reductoisomerase 2, Acetohydroxy-acid isomeroreductase 2, Alpha-keto-beta-hydroxylacyl reductoisomerase 2.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: LDH_PEDAC
Sequence: MSNIQNHQKVVLVGDGAVGSSYAFAMAEEGIAEEFVIVDVVKVRTVGDALDLEDATPFTAPKNIYSGEYSDCKDADLVVITAGAPQKPGETRLDLVNKNLNILSTILKPVVDSGFDGIFLVAANPVDILTYATWKFSGFPKEKVIGSGISLDTARLRVALGKKFNVSPESVDAYILGEHGDSEFAAYSSATIGTKPLLEIAKEEGVSTDELAEIEDSVRNKAYEIINKKGATFYGVGTALMRISKAILRDENAVLPVGAYMDGEYGLNDIYIGTPAVINGQGLNRVIEAPLSDDEKKKMTDSATTLKKVLTDGLNALAEKQDK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.