PharMolix/UniProtQA huggingface dataset:
Protein: NANH_CLOPF
Sequence: MCNKNNTFEKNLDISHKPEPLILFNKDNNIWNSKYFRIPNIQLLNDGTILTFSDIRYNGPDDHAYIDIASARSTDFGKTWSYNIAMKNNRIDSTYSRVMDSTTVITNTGRIILIAGSWNTNGNWAMTTSTRRSDWSVQMIYSDDNGLTWSNKIDLTKDSSKVKNQPSNTIGWLGGVGSGIVMDDGTIVMPAQISLRENNENNYYSLIIYSKDNGETWTMGNKVPNSNTSENMVIELDGALIMSTRYDYSGYRAAYISHDLGTTWEIYEPLNGKILTGKGSGCQGSFIKATTSNGHRIGLISAPKNTKGEYIRDNIAVYMIDFDDLSKGVQEICIPYPEDGNKLGGGYSCLSFKNNHLGIVYEANGNIEYQDLTPYYSLINKQ
What is the function of this protein?
Sialidases have been suggested to be pathogenic factors in microbial infections.
What are the official names of this protein?
Sialidase, Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IHFA_METS4
Sequence: MAGKTVTRADLTEAVYQRVGLSRTESAALVETVLSEICTCLASGETVKLSSFGSFVVRDKGKRVGRNPKTGVEVAIEPRRVMVFKPSNVLKARINGGAAEPDDE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: UBIG_SHESW
Sequence: MQHNTNVDPQEIAKFERMAETWWDLNGEFKPLHLLNPLRLNYIDQTTGGIFGKKVLDVGCGGGILSESMARIGAEVDGLDMGEEPLEVARLHALETGVNITYVKNTAEAHSQDHQGYYDVVTCMEMLEHVPNPQSVIKACCDMVKPGGFVFFSTINRNLRSYVETILGAEYLLKMLPVGTHDHNKFIKPSELIELVDNTDLICKDAVGITYNPLTGIFKYTPRVDVNYMIATQKVD
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: PER_DROPI
Sequence: SKSSTETPLSYNQLNYKENLQRFFNSKPVTAPTQLDPVNRDSSYASTSREDACSAISPDHGGECSGGSGSSGNCTTNSNIRMSSFTNTSITGTGTSGCGNSGGKLSESGPVEVGGAAADAGPSLAADNSIPPISVTLTESLLN
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: PCF11_HUMAN
Sequence: MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLNRISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV
What is the function of this protein?
Component of pre-mRNA cleavage complex II.
What are the official names of this protein?
Pre-mRNA cleavage complex 2 protein Pcf11, Pre-mRNA cleavage complex II protein Pcf11.
Protein: AROE_LISMO
Sequence: MTNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVYKPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: PYRG_METJA
Sequence: MKIMKFIFITGGVISSLGKGITAASLGRLLKARGFKVNMIKIDPYLQIDAGTMSPYEHGEVFVTEDGGESDLDLGHYERFIDENLTKNNNITTGKIYWSVLTKERKGEYLGKTVQVIPHITNEIKDWIKNLGEGYDITIVEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRAAGELKTKPTQHSVKELRSIGIQPDILICRTEMPISDKIREKLALFCDVDKEAVIEARDARTIYEVPLNLEKEGLGKLVTKKLNLPDREPDLDEWRKFVDRVINPLNEVTIGIVGKYVELKDAYLSITEALIHAGAKNDTKVNINWIHSERLESEEFEELLDRYREDNQLDGILVPGGFGDRGVEGKINAIKYARENDIPFLGICMGMQCAVIEFARNVCGLEGANSTEFDENTKYPVVDLLPEQKEIDAKGGTMRLGAYPAILMEGTLAYKLYGRKEVYERHRHRYEVNPEYHEILENHGLTISGKSPDGRLAEFIEISKNRYFIATQAHPEFKSRPNKPHPLFDGLVRASLGEKIK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TRMA_SALTY
Sequence: MTPEHLPTEQYEAQLAEKVARLQSMMAPFSGLVPEVFRSPVSHYRMRAEFRLWHDGDDLYHIMFDQQTKSRIRVDTFPAASQLINTLMKAMIAGVRDNHALRHKLFQIDYLTTLSNQAVVSLLYHKKLDEEWREAATALRDALRAQGLNVHLIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALEVTKDSKGDLLELYCGNGNFSLALARNFNRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKRYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHTVSRLALFDQFPYTHHMECGVLLTAR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: PYRG_VEREI
Sequence: MTKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIETRMNRANNFTTGKIYQSVLEKERRGDYLGKTVQVIPHVTNEIQEFIQRGAGMGTPVAVDVAIVEIGGTVGDIESLPFLEAVRQMSLRMGANNSTFVHLTYLPWIATAGELKTKPTQHTVQKLREIGIQADALLCRADRRIPGEERAKISLFTNVPEWGVISMWDVDIIYKVPRMLHEQGLDGLICDKLRLNTRPTNLQRWDDLVYATEHPQGAVTVAMVGKYVDLSDSYKSVNEALRHAGMRNHVRVQIDHVDSETIDSADAAARLARYDAILVPGGFGQRGVEGKIATARYAREHKLPYLGICLGMQVATIEYARHVAGLANANSTEFDPATPHPVIALITEWQDADGSIQQRDQDSNLGGTMRLGAQSSDVLAGTLAHRIYGDVVTERHRHRYEANVNYLEPLRKAGLVIAALTQREQLTEIVELPQSMHPWFIGVQFHPEFKSTPWNGHPLFNSFIAAAKARHQARHEGPA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SOX18_MOUSE
Sequence: MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLEPGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSPPPESPSLEGTEQLEPTADLWADVDLTEFDQYLNCSRTRPDATTLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG
What is the function of this protein?
Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis (PubMed:7651823, PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912, PubMed:26939885).  Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers (PubMed:18931657, PubMed:26939885).  Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells (PubMed:18931657).  Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17 (PubMed:16895970).  Interaction with MEF2C enhances transcriptional activation (PubMed:11554755).  Besides, required for normal hair development (PubMed:11094083, PubMed:12748961).
What are the official names of this protein?
Transcription factor SOX-18.
What are the subcellular locations of this protein?
Nucleus.
Protein: GSTA3_DICDI
Sequence: MTKPQLSYFKVRALGQFPRVLLSYLSIDYDNNYIDKIDENIIDDLKYGQLPLYTDSNGFKLVQSMAISKYIASQHDFVGKTPEEKALVDETLAAVNIDVFTFIIRVFRGVEEKEKIQEIIIPRFFAKWNQILGEKKYLAGGNSYTLADLYVYVAYEYIGYVLPFAADLLYNGKFPHLDSLKEHFESNKGVAEYLKNRPITERKI
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Putative glutathione S-transferase alpha-3, GST class-alpha 3.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Alpha family.
Protein: GATA_CARHZ
Sequence: MELYYLSAKEITEKIKAKEISAVEVAKATFDRIEAVEPKIQAYVTVTRELGLKMAREVDEKIARGEDPGPLAGVPVAIKDNMSTAGIRTTCSSKILENYIPPYDATVVEKLKEAGAVFTGKTNLDEFAMGSSTENSRFFPTRNPWDLERVPGGSSGGSAASVAAGEAVVALGSDTGGSIRQPAAFCGIVGLKPTYGAVSRYGLVAFASSLDQIGPFARTVEDAALLLNVIAGHDPKDSTSADIEYPDYLSFLNQDIKGLKIGLPKEYFIDGIDAGVKKAIDDAIKVLESLGAVFEEVSLPHTKYSLPVYYLIAPAEASSNLARYDGVRYGYRDFEAEDVVEMFSRTRAEGFGAEVKRRIMLGTYALSAGYYDAYYLKALKVRTLIKEDFDRAFTKVDLLLTPTTPTPAFKFGEKTSDPVSMYLSDIFTMAVNLAGLPGISVPAGFDGHLPVSFQLIGKPFDEGTLLKVAHAFEQNTEFHKARPKL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: HSCA_SHEON
Sequence: MALLQIAEPGQSAAPHQHRLAVGIDLGTTNSLVAAVRSGVTATLPDENGQHSLPSIVRYTQEGIEVGYVAAMSSAQDPKNTIVSVKRFMGRSLTDIQSGEQSFPYQFEASENGLPLFVTPQGLVNPVQVSAEILRPLIERAEKTLGGELQGAVITVPAYFDDAQRQGTKDAASLLGVKVLRLLNEPTAAAIAYGLDSKQEGVIAIYDLGGGTFDISILRLNRGVFEVLATGGDSALGGDDFDHLLQAHMLQVWQLTDIDSQLSRQLLIEARRVKEALTYASDTEASLTLADGSVLKQVVTKAQFEGLIAALVKKTIASCRRTLRDAGVTADEVLETVMVGGSTRVPLVREQVEAFFGKAPLTSIDPDRVVAIGAAIQADILVGNKPESELLLLDVIPLSLGIETMGGLVEKVVSRNTTIPVARAQEFTTFKDGQTAMAFHVVQGERELVDDCRSLARFTLKGIPPLAAGAAHIRVTFQVDADGLLSVTAMEKSTGVQSSIQVKPSFGLSDSEIATMLKDSMKHAKEDIGRRMLAEQQVEAARVLESLNAALSKDGDLLTSDERQQIDTVMAELVQVAGSDDADTIKKAIEILDEHTQDFAAKRMDNSIRVAFKGQSIDKI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL7_ACICJ
Sequence: MADLANLVEQLSSLTVLEAAELSKLLEEKWGVSAAAPVAVAAAAPAGGGAAAAPVEEKTEFNVILKSSGDKKINVIKEIRTITGLGLKEAKDLVEGAPKTVKEGVNKDEAEKIKKVLEEQGASVGIE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SPKD_SYNY3
Sequence: MNVQVLDRYEIVKSLGSGGFGDTFLAKDTQIPSQKLVVIKRLKPANANSNTSTELIQKLFEKEASVLEDLGEHNSQIPKLYSYFSNDNEFYLVQEYIQGVSLNEIAPISSEQAKTILSSLLTTLKYIHSKGIIHRDIKPENIILRDSDHLPVLIDFGAVKETMGAVTLGSGSTVSSVVIGTRGFMAPEQSSGRSVFSTDLYALGLTIIYTLTKKLPVEFSSDQQTGQLDWQSHVSKIDSVLAKVINKAIEMEPSRRYSSAEAMYQALHSLISSGAEPALPMETVRVAPSNEFLVTRSSTKTAETVVKPVGNSHNNYSNNNGKSKIATLLTVLIGIIVVTAGLGGGFIITQQIKEAEARAAQAEKEKQEAEQKRIEAEQKIAENEKRQRELEQKRVEEERQRLAAEAERAKQERQRLAAERQRVQVLANQAKAMASGASATIGGIPGSKNIRSGPGTDYGVITQGYTGEGLDILDSSTDSSGHVWYKVYHYGSGSTGWIASQLVNF
What are the official names of this protein?
Serine/threonine-protein kinase D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: ASSY_HAEI8
Sequence: MSNTILQNLPKGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYNAIPKKAMAYGAENARLIDCRSQLAHEGIAAIQCGAFHISTGGIPYFNTTPLGRAVTGTMLVAAMKEDDVNIWGDGSTFKGNDIERFYRYGLLTNPNLKIYKPWLDVQFIEELGGRLEMSQFLIENGFDYKMSVEKAYSTDSNMLGATHEAKDLEQLSTGMKIVKPIMGVAFWDEKVEIKPETVTVTFEDGVPVALNGKHFDNAVDLILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYRINGIRLGRLLYQGRWFDPQALMLRETAQRWVAKAITGTVTLELRRGNDFTILNTESPNLTYEAERLSMEKVEDAPFDPVDRIGQLTMRNLDVSDTRGKLGIYAQTGLLSAIKDSVLPQLGKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_CHLFF
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDIIVCSVRDVEPDSSIKKGDVVKAVIVRTRRDILRKDGSSLRFDTNSCVIIDEKGNPKGTRIFGPIAREIRDRGFVKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CBIE_SALTY
Sequence: MLTVVGMGPAGRHLMTPAALEAIDHADALAGGKRHLAQFPAFGGERFTLGADIGALLSWIAARRDKGIVVLASGDPLFYGIGTRLVAHFGIEQVRIIPGISAVQYLCAQAGIDMNDMWLTSSHGRCVSFEQLANHRKVAMVTDARCGPREIARELVARGKGHRLMVIGENLAMENERIHWLPVSAVNADYEMNAVVILDER
What is the function of this protein?
Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8.
What are the official names of this protein?
Cobalt-precorrin-7 C(5)-methyltransferase, Cobalt-precorrin-6Y C(5)-methyltransferase, Cobalt-precorrin-6 methyltransferase, Cobalt-precorrin-6Y methylase.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: YIDD_STRAW
Sequence: MKYPLLALIKLYQWTISPLLGPVCKYYPSCSHYGYQAIDRHGAIKGTALTAWRILRCNPWSLGGVDHVPPRKRPRWHEMLRNAWRARKGGPSAAEPAIEGHIPSSPAAETPSHVQGA
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDK6_XENTR
Sequence: MSSFRWVRPLQLTLALIKPDAVANPVISEAVHQKILENNFLIIRHKELHWRSTDSQRFYCEHKGRFFYQRLVEFMSSGPMQAYILAHEDAVQLWRNLMGPTKVFRARIVAPGTVRGDLGLTDTRNTTHGSDSVESACREITFFFPEFNTSDWYEKQEPRYRTGPVFYDEERSEHRLEGE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase 6, NDK 6, NDP kinase 6.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: DNAG_LISIN
Sequence: MARIPEEVIDQVRNQADIVDIIGNYVQLKKQGRNYSGLCPFHGEKTPSFSVSPEKQIFHCFGCGKGGNVFSFLMEHDGLTFVESVKKVADMSHLDVDIELPEERDTSNLPKETSETAKMVEMHQLTAKLYHYILMETEEGAAALTYLKERGMSEQMMASFQIGFAPNHHATITSFLEKRGMDLQLAGTAGLLSERDDGQMVDRFRNRIMFPITNDRGQINAFSGRLFDRDDGPKYLNSPETPIFNKRRTLFHFSEARQAIRKQEEITLMEGFMDVISAEEAGVQNAVASMGTSLTEEHADLIKRLTNRAIICYDGDRAGIEAAYKAGTLLVERNRLDVFVLQLPAGKDPDDFIRASGADKFKEIYKQQRMTWTAFKINYLRKERNLQNETDKIAYIDDCLREIAKLDQAVERELYLKQLADEFELTIETLKQQLQQSLKNTHKERQNHSYNEPPIDDSFMGMIPQEDSEMLFSFEQPTKKLSAHTTAEQQLMKAMMENRDSFLLIKQLLGDTEFYHDNYQALYTYLIGYFAEGNDADPHKFMDSVPDAGMKGLISSLEMVISPDEQGKTQFEDYIKSLKRFKLEQAKKELEQQLAAFNRENDKENEIRVMLEIVQLNRKLNSGQLD
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: ERF1_CRYHO
Sequence: MSDNDTNVKQWKVRRLIATLEAARGNGTSMISLVIKPKDEISRISKMLADEYGTASNIKSRVNRLSVLSAITSTQQRLKLYNRTPQNGLVVYCGTLITEDGKEKKVNIDFEPFKPINTSLYLCDNKFHVDALKELLETDDKFGFIIVDGNGALYGVVQGSSREVLLRFNVDLPKKHGRGGQSALRFARLRMEKRHNYLRKVAETATTMFITNDQVNVAALILAGSADFKNELAQSDIFDQRLASKILKIVDVSYGGDNGFNQAIELSSDALQNVKFVQEKKLITKFFDEVAQDTGKYVYGINETLQALEMGAIELLIVWENLETKRMVVKNPSTGEEKVFLNSPTEQHDESKFKDPETGAELDVIEILPLTEWLVNTYQNYGAQLEFVTNKSQEGNQFQKGFGGFGGILRYKVDFQDYAVVEDDLDEFI
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUT4_MOUSE
Sequence: MPSGFQQIGSDDGEPPRQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAFRRTPSLLEQEVKPSTELEYLGPDEND
What is the function of this protein?
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404).  Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404).  Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404).
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 4, GT2, Glucose transporter type 4, insulin-responsive, GLUT-4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:26629404, PubMed:26240143, PubMed:27354378). The dileucine internalization motif is critical for intracellular sequestration (PubMed:26240143, PubMed:26629404). Insulin stimulation induces translocation to the cell membrane (PubMed:27739494).
Protein: RR4_PINTH
Sequence: MSRYRGPRLKIIRRLKTLPGLTSKRPKNRKDSMNRSSSRKISQYRIRLEEKQKLRFHYGLTERQLLKYVRIARRAKGSRVRSIAITEMRLDKSFSIGYGSTSGARQLVNHGHIRVNDHMVDIPSYPCKPQDVITIRDQQRLRAIIKKNIDLFQRDKLPNHLTFHSLQYKGFINQIIDSKWINLKINELLVVEYYSRQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RF3_LISMH
Sequence: MSQDLQKEVASRKTFAIISHPDAGKTTITEQLLLFGGVIRSAGTVKGKKSGKFATSDWMEIEKQRGISVTSSVMQFDYNGSRINILDTPGHSDFSEDTYRTLMAVDSAVMVIDAAKGIEAQTLKLFKVCRMRGIPIFTFINKMDRQGKMPLELLAELEEVLGIESYPMNWPIGMGKELAGLYDRYHRVIEQYRSEEDERFLPLGEDGDLKEAHAIQKSLYYDQALEEIMLLDEAGNDFSRERIIAGEQTPVFFGSALTNFGVETFLRTFVDFAPSPSSHESNEGVIEADNPKFSGFIFKIQANMNPAHRDRIAFIRICSGEFERGMNVTLTRTGKSMKLANSTQFMADDRETVNRAVAGDIIGLYDTGNYQIGDTITNGSKKLEFEKLPQFTPELFMRVYAKNVMKQKHFHKGVEQLVQEGAIQLFKTWRTEEYIIGAVGQLQFEVFEHRMRGEYNSEIRMEPIGKKIARWVKEEDADEKLSTARSMLVKDRFDQPLFLFENEFAINWFNDKNPDIELTSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_KLEP3
Sequence: MSEETIVNCPTCGKNVVWGEQSPFRPFCSKRCQLIDLGEWAAEEKRIPSAGDLSDSDDWSEQQP
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.