PharMolix/UniProtQA huggingface dataset:
Protein: MYRF2_CAEEL
Sequence: MGDLNPAETPEPKKNPVAKIASNLYSTQIVKPVPSVSNSTNLSPCQNPNMTNLFYITLLQNKLNKYTQQLLKKNEEGLNDPLANVEQFNIIQFLQNDVDFNLPIEAFEQGNMDQNIRIDPILQRQQMANQPMLMPQHMLQQLHQQQIYEQQLASMPMTPAITDLTRHGSSSSPSTTNSDPPYSPEGLNNFGLGTQRPNHGVIPNDISNVPQHINRQFNPRMGPNTSPNPPSFPQFLNSNHPTPGSYVQSISPDSNGQGFAQSNLYNALNVSSDESINGSDDIPNRKRPRMDQNMDPSFIMHAPVSGKLGAEVTEEGGQPNIRFFKYQEEQWCPMYDANGEELGRLQVHVLADKGFNYSTNDNCFVNQKKNHFQVTVKIEAIDPSPPQCFKINGVCKPIENFQLSFVGAKSESQNSEIPIRQSTTERKPILHTPVLFKIVERRMTIVTVPRLHFSETTLNNQRKNLRPNPDQKYFNLVVRLYATATDGTTVLMQAFASERVIVRATNPGSFEPPEMVDASWNKNGGILSTNGPVVIGKSEPRAQLTVDGDIYSSGRVMYPSDIRLKDNITEKGAKDALENLQKLRIVDYFYKPEVASKWGLTEDQRKRTGVIAQELAAVLPDAVKDLGDYLTVNESRVFYETVLATQELCRLTGDLDQKIDDKVAEISQRLTQYAQKKKMLNSMASGLNSEGRSLNASRTSLDSSASALTLTNTKKNRRSSRKDKKDAPKSKMTHGTVIGLVGVMAFCLLAMSALYILDWHNRNFGYHHFTPSATTSGPKEGPGNVVIPLDHYVPLRQPDAPPLVPFCPMETCRGYCCMEYDKDHAELEITEYDPNTATDNDFGFKADTRSDFTLKGFGNNVKISLPELGMQIDERYCIEKSCVKKRKVYSLFIPMTRYLPNVPLEVQIDVPSSKVVNNCGYIQEFDNRKCDETGSSSTETDAPRSIQLFDNTFQVSAGQWTQSAYRFRVGYSTELCSIDDTHFGGFYEEYNLIFYRACNRTNSTAINVV
What is the function of this protein?
Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531).  Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531).  Acts in complex with myrf-1 paralog (PubMed:28441531).
What are the official names of this protein?
Myelin regulatory factor homolog 2.
What is the protein family that this protein belongs to?
Belongs to the MRF family.
What are the subcellular locations of this protein?
[Myelin regulatory factor homolog 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Apical cell membrane; Single-pass membrane protein. Note=In early L1 larvae, localizes to the cell membrane, but then localizes to the nucleus in late L1 larvae (PubMed:33950834). Cell membrane localization is promoted by pan-1 (PubMed:33950834). SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 2, N-terminal]: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 2, C-terminal]: Endoplasmic reticulum membrane; Single- pass membrane protein.
Protein: ILVC_SYNWW
Sequence: MARMFYDADANLENLKGKTIAVMGFGSQGHAQAQNLKESGLNVIVGLRKPFDEASEKEWNAVIAAGITPMSVAEAAEAADVIQILLPDEVQARVYNAEIKPYLKAGNALGFSHGFNIHFGQIVPPAFVDVFMVAPKSPGHLVRRMYVKGAGVPGLVAVQQDYSGKAKDLALAYACGIGCTRAGVIETSFQEETETDLFGEQCVLCGGVTELVKAGFETLVEAGYQPEIAYFECMHELKLIVDLMYEGGMSYMRYSISDTAEWGDYTKGPEIIGEEARYAMYEALQDIQDGSFAKGWLLENMVGRPRFNALKRQNREHLIEEVGAELRGMMPWLKETK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NAD(P)(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GUX1_ARATH
Sequence: MANSPAAPAPTTTTGGDSRRRLSASIEAICKRRFRRNSKGGGRSDMVKPFNIINFSTQDKNSSCCCFTKFQIVKLLLFILLSATLFTIIYSPEAYHHSLSHSSSRWIWRRQDPRYFSDLDINWDDVTKTLENIEEGRTIGVLNFDSNEIQRWREVSKSKDNGDEEKVVVLNLDYADKNVTWDALYPEWIDEEQETEVPVCPNIPNIKVPTRRLDLIVVKLPCRKEGNWSRDVGRLHLQLAAATVAASAKGFFRGHVFFVSRCFPIPNLFRCKDLVSRRGDVWLYKPNLDTLRDKLQLPVGSCELSLPLGIQDRPSLGNPKREAYATILHSAHVYVCGAIAAAQSIRQSGSTRDLVILVDDNISGYHRSGLEAAGWQIRTIQRIRNPKAEKDAYNEWNYSKFRLWQLTDYDKIIFIDADLLILRNIDFLFSMPEISATGNNGTLFNSGVMVIEPCNCTFQLLMEHINEIESYNGGDQGYLNEVFTWWHRIPKHMNFLKHFWIGDEDDAKRKKTELFGAEPPVLYVLHYLGMKPWLCYRDYDCNFNSDIFVEFATDIAHRKWWMVHDAMPQELHQFCYLRSKQKAQLEYDRRQAEAANYADGHWKIRVKDPRFKICIDKLCNWKSMLRHWGESNWTDYESFVPTPPAITVDRRSSLPGHNL
What is the function of this protein?
Glycosyltransferase required for the addition of both glucuronic acid and 4-O-methylglucuronic acid branches to xylan in stem cell walls.  In association with GUX2, is responsible for almost all of the substitutions of the xylan backbone in stem glucuronoxylan.
What are the official names of this protein?
UDP-glucuronate:xylan alpha-glucuronosyltransferase 1, UDP-GlcA:xylan glucuronyltransferase 1, Glycogenin-like protein 1, Plant glycogenin-like starch initiation protein 1, Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 1, AtGUX1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: HPT_PONAB
Sequence: MSALGAVIALLLWGQLFAVDSGNDVMDISDDGCPKPPQIAHGYVEHSVRYQCKNYYRLRTEGDGVYTLNSEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSRHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVPVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTEHLKYVMLPVADQDQCVRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAKN
What is the function of this protein?
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine.  Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.  Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.  Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
What are the official names of this protein?
Haptoglobin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_BORA1
Sequence: MRIDVITLFPEMFGVVRDLGVTGRAHAQGLWSLHAWNPRDFTTDVHRTVDDRPYGGGPGMVMMAAPLEAAVKAAQAARAAQHLPPAPVALLSPVGRRYDQGAAQQLASSDGLVLICGRYEGLDQRFIDRCVTLEISLGDFVLSGGEIAALAVIDAAVRLLPGALGDGDSALQDSFNDTLSGLLDSPHYTRPEVYEDQAVPAELLSGHHARIARWRRDQSLRLTLARRPELIDRARTQGWLSYADECVLAELQGVVAPPDPRKKRRRKPAA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_STAAT
Sequence: MTETANLFVLGAAGGVEWGTVIVQVLTFIVLLALLKKFAWGPLKDVMDKRERDINRDIDDAEQAKLNAQKLEEENKQKLKETQEEVQKILEDAKVQARQQQEQIIHEANVRANGMIETAQSEINSQKERAIADINNQVSELSVLIASKVLRKEISEQDQKALVDKYLKEAGDK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL21_CHLTR
Sequence: MEPYAVIQTGNKQYQVRKGDVIDVELLDGISEENKEVLFQDVLFTFDGEKASVGAPTVGNAVVKGELVSFVRGEKVVAYKYKKRKNYHKKIGHRQNYLRVKISDLVM
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: STR15_ARATH
Sequence: METTAFNTTSRIGNWSSAISPPLQTCGSFKCQLPTRRGVIVADLRNSNFRWRKATTTSRGNVAAEAVKIPTSVPVRVARELAQAGYRYLDVRTPDEFSIGHPTRAINVPYMYRVGSGMVKNPSFLRQVSSHFRKHDEIIIGCESGQMSFMASTDLLTAGFTAITDIAGGYVAWTENELPVEE
What are the official names of this protein?
Rhodanese-like domain-containing protein 15, chloroplastic, Protein DARK INDUCIBLE 1, Senescence-associated protein 1, AtSEN1, Sulfurtransferase 15, AtStr15.
What are the subcellular locations of this protein?
Plastid, chloroplast. Thylakoid. Note=Associated with membrane.
Protein: DNAJ_RICCN
Sequence: MSQNYYQILGVSKTASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKEINAAYDVLKDEQKRAAYDRLGHDAFQNQQSRGGGGNHGGFHPDINDIFGDFFSDFMGGSRRSSRPTSAKVRGSDLKYNLTINLEEAFHGIEKNISFSSAVKCDTCHGSGSEKGETVTTCDACSGVGATRMQQGFFTIEQACHKCQGNGHIIKNPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDITIKPHDIYKVDGANLHCKLPISFVNAALGGEIEVPVIEGGKVNLTIPAGTQNGDQLRLRSKGMSKMRSTIRGDMLTHIHVEVPKNLSKRQRELLEEFKKESINEKENDGSFFNKMKSLWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCC_SALPC
Sequence: MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYEKEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU4LM_ARCPU
Sequence: MSMVYFNIFMAFIVSFMGLLMYRSHLMSSLLCLEGMMLSLFVMMSMTILSNHFTLASMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GCSH_LEGPA
Sequence: MNDLKFTTTHEWLREDEEEVTVGITDHAQELLGDMVFVELPEIGDEVSAGQELGVVESVKAASDFYAPISGVVTAVNEAVGKNPALVNHDPYHEGWLVKLKPSHPDEIKSLLSDEQYQNEIAEEN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RL20_MARMS
Sequence: MPRVKRGVQARRRHKKILKQAKGYYGARSRVFRVAKQAVIKAGQYQYRDRRQRKRQFRALWIARINAAARINGLSYSRFIAGLKQAAIEIDRKVLADLAVYEKEVFAAIVEKAKVSLA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ERA_AMOA5
Sequence: MHTSPHQAGFVTIIGKPNVGKSTLMNRLVGERLSIITPKAQTTRHSICGIVSDTDFQIIFTDTPGILKPAYELQESMMHMLQHALVDTDVLLWLVDIKEKEVPPIVEKVLAQGRIPVLLLINKIDLIAGQEALESLVEYWKQKVNVAQIIPIAALQGFQIEQLLKHILVYLPAHPPFYPKDMLTDRPERFFVAEIIREQILYKYQQEIPYAVEVVIEEFKEEASLIRISAMIYVEKKSQKGILIGKQGESLKQVGIAARQALEKFLEKQVFLQQHVKVLPGWRSQNKLLQRFGYES
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: ATPA1_POLNA
Sequence: MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVADGIVRIHGLSDVMQGEMLEFPATADGTPTYGLALNLERDSVGSVILGEYEHIAEGDTVKCTGRILEVPIGPELLGRVVNALGQPIDGKGPINAKLSDVIEKVAPGVIARKSVDQPLQTGLKSIDSMVPIGRGQRELIIGDRQTGKTAVAIDAIINQKGKGVSCVYVAIGQKASSIKNVVRSLEQAGAMDYTIVVAASASESAAMQYVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNEKYVEDFTKGAVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLIKNLSGGIRTDLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQSQYSPLSVSTMGATLFAVNKGFMDDVDVKKVLAFESGLHAWLKDKHAPLMAKLEANKAMDKDAEAELTTAVTAFKKSFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y556_PELPD
Sequence: MAFIPTTRSEMHRRGWEQLDVIFVNGDAYVDHPAFGVPLLARWLEKHGFRVGVIAQPDWRSVEPFMALGRPRLFFAASAGAMDSMVAHYTPARKLRHDDAYTPGNRHGARPNRATLIYTSRLKEAFRDVPVVIGGIEASLRRFAHYDYWENRVRRSLLFDAKADLLLYGMAERSMLELAQRMGRGESLADIRGLRGTCWVEKAGHHLTDHLEIPCFEECGSDRLKFAEAFRLASREQNPYNGRTIVQRHGDRLLVCAPPSLPLEEAEMDSLYALPFEKAPHPSYGETIPAWEQIRCSITSHRGCFGGCSFCAIAMHQGKLIQSRGQSSVESEIRELVRKPWFRGSISDIGGPTANMYGLSCGDSAAMKCCRRESCLFPKQCRHLIVDDRRAVRLLHAARDFAGVRHVAVSSGVRYDLLERQPAYCRELIAHHVGGLLKVAPEHLVERVTMLMRKPGLAVFERFLSRFREESRRLGKPQGIVPYLISGHPGCSLADMLELALALQRLGLRVEQVQDFTPTPGTCATCMYYSGIDPETGEKLYVATSDREKGLQKALLLGHLPGERKKVLEALALLGREELATVLLTAGRSEAVSAKRPHSVGQGVIHPGRERKAGRGKGTKKAR
What are the official names of this protein?
UPF0313 protein Ppro_0556.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: NUOK_BAUCH
Sequence: MISLSYSLSLAAILFMLGLTGIMIRRNLLFLLLGLEIMINAAALAFVIVGQYWGQADGQVMYILTVTIAATEASIGLALLLHLYRYYQTLDIDLISEMHR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UL131_HCMVA
Sequence: MCMMSHNKAFFLSLQHAAVSGVAVCLSVRRGAGSVPAGNRGKKTIITEYRITGTRALARCPTKPVTSMWNSSWTSR
What are the official names of this protein?
Uncharacterized protein UL131.
Protein: CAS9B_STRTD
Sequence: MTKPYSIGLDIGTNSVGWAVTTDNYKVPSKKMKVLGNTSKKYIKKNLLGVLLFDSGITAEGRRLKRTARRRYTRRRNRILYLQEIFSTEMATLDDAFFQRLDDSFLVPDDKRDSKYPIFGNLVEEKAYHDEFPTIYHLRKYLADSTKKADLRLVYLALAHMIKYRGHFLIEGEFNSKNNDIQKNFQDFLDTYNAIFESDLSLENSKQLEEIVKDKISKLEKKDRILKLFPGEKNSGIFSEFLKLIVGNQADFRKCFNLDEKASLHFSKESYDEDLETLLGYIGDDYSDVFLKAKKLYDAILLSGFLTVTDNETEAPLSSAMIKRYNEHKEDLALLKEYIRNISLKTYNEVFKDDTKNGYAGYIDGKTNQEDFYVYLKKLLAEFEGADYFLEKIDREDFLRKQRTFDNGSIPYQIHLQEMRAILDKQAKFYPFLAKNKERIEKILTFRIPYYVGPLARGNSDFAWSIRKRNEKITPWNFEDVIDKESSAEAFINRMTSFDLYLPEEKVLPKHSLLYETFNVYNELTKVRFIAESMRDYQFLDSKQKKDIVRLYFKDKRKVTDKDIIEYLHAIYGYDGIELKGIEKQFNSSLSTYHDLLNIINDKEFLDDSSNEAIIEEIIHTLTIFEDREMIKQRLSKFENIFDKSVLKKLSRRHYTGWGKLSAKLINGIRDEKSGNTILDYLIDDGISNRNFMQLIHDDALSFKKKIQKAQIIGDEDKGNIKEVVKSLPGSPAIKKGILQSIKIVDELVKVMGGRKPESIVVEMARENQYTNQGKSNSQQRLKRLEKSLKELGSKILKENIPAKLSKIDNNALQNDRLYLYYLQNGKDMYTGDDLDIDRLSNYDIDHIIPQAFLKDNSIDNKVLVSSASNRGKSDDVPSLEVVKKRKTFWYQLLKSKLISQRKFDNLTKAERGGLSPEDKAGFIQRQLVETRQITKHVARLLDEKFNNKKDENNRAVRTVKIITLKSTLVSQFRKDFELYKVREINDFHHAHDAYLNAVVASALLKKYPKLEPEFVYGDYPKYNSFRERKSATEKVYFYSNIMNIFKKSISLADGRVIERPLIEVNEETGESVWNKESDLATVRRVLSYPQVNVVKKVEEQNHGLDRGKPKGLFNANLSSKPKPNSNENLVGAKEYLDPKKYGGYAGISNSFTVLVKGTIEKGAKKKITNVLEFQGISILDRINYRKDKLNFLLEKGYKDIELIIELPKYSLFELSDGSRRMLASILSTNNKRGEIHKGNQIFLSQKFVKLLYHAKRISNTINENHRKYVENHKKEFEELFYYILEFNENYVGAKKNGKLLNSAFQSWQNHSIDELCSSFIGPTGSERKGLFELTSRGSAADFEFLGVKIPRYRDYTPSSLLKDATLIHQSVTGLYETRIDLAKLGEG
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein (By similarity).  The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA.  Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer yielding blunt ends; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA).  Cas9 recognizes a 3'-G-rich protospacer adjacent motif (PAM, GGG in this organism) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs.  PAM recognition is also required for catalytic activity.  Complements the gRNA coprocessing defect in a cas9 deletion in S. pyogenes strain 370, and cuts target DNA in Cas9:gRNAs mixing experiments with S. mutans strain UA159.
What are the official names of this protein?
CRISPR-associated endonuclease Cas9 2, Cas9*, St3Cas9.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas9 family. Subtype II-A subfamily.
Protein: RS15_THEFY
Sequence: MPIDTATKQKIIAEYATKEGDTGSPEVQVALLTHRINQLTEHLKEHKHDHHSRRGLLLLVGRRRRLLQYVAKKDINRYRRLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL15_METM6
Sequence: MIRKSKKITKMRGSRTCGYGEAKKHRGAGHRGGRGNAGHQKHKWLSVCKFNPDYFGKYGFNRNPGLIKQLETINIGELEEYILKYKDAFQVEDGKVVVDATEIGFEKVLGKGRISTAMVVKAVEFSEGAKEKIEAAGGEFVEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RLMH2_CALS4
Sequence: MKIQIIAVGTIKENYIKDGIKFYLDKLKKIYDIEIVEIKEEEDPGTPASREKVLETEGERILYKIDRESFVIALAIEGKEVSTEEFASLVKKAFGMGYKKVVFVIGGSLGIWGKVKERADVNISFSKMTFPHQLTRLLLLEQIYYALL
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H 2, 23S rRNA (pseudouridine1915-N3)-methyltransferase 2, 23S rRNA m3Psi1915 methyltransferase 2, rRNA (pseudouridine-N3-)-methyltransferase RlmH 2.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CLOBH
Sequence: MSRVGKLPVAIPNGVTVTVTPDNVVTVKGPKGELVKAMSNKINIAVEDNSVVVTRDNDHKDVRALHGLTRALVNNMVTGVNEGYVKTLELIGVGYRAQLQGKKLVLSLGFSHPVEMEAVSGVEFEVEGGTKVKVKGIDKELVGAVAADIRKWRKPEPYKGKGIKYENEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: THIG_DESRM
Sequence: MKEVFSVGGKELTSRLLIGSGKYSTNKLIPAILDASGSQVITMAMRRVDTEFTEENILNYIPSDCVLMPNTSGARNAQEAIRIARLARAAGCGDWVKIEVISDNRYLLPDNYETIRATEVLTAEGFQVFPYMSPDLMVAKELERVGAAAVMPLGAPIGSNRGLQTRELVRILIEEISLPVIVDAGIGRPSEAAEAMEMGAAAVLVNTAVATAKDPVAMARAFGLAVEAGRTAYLAGPGATQQVARASSPLTGFLREE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYKC_SCHPO
Sequence: MSEEQVNGVTQAVKALVLDPVTGEQVSKTELKKREKQRARELAKAKKQAEKAASAPVAAPKSSSKKEEDLDPSQYFENRSRTIMELRQTKDPNPYPHKFQVTITLPEFIAKYEGLARGETKPEVEVAVAGRVLGLRTAGNKLRFYEIHADGKKLQVMCQAQDADTVDFAAQHEHLRRGDIIGIRGYPGRSNPKGRADGELSIFARQCVLLSPCLRMLPKEHYGLKDLEIRHRQRYLDLIMNRSTRDRFVMRSRIIQYIRHFFDSRDFMEVETPMMNMIAGGATAKPFVTHHNDLDMDLYMRIAPELYLKMLVVGGLDRVYEIGRQFRNEGADLTHNPEFTSIEFYQAYADYYDLMDTTEELLSGLVKDLTGSYKVPYHPEGPEGPKWELDFSRPWRRINMIEYLEEKLNTKFPPGDQLHTPEANAFLRDLCAKHGVECAPPQTCSRLLDKLVGEFIESECINPTFIIGHPQMMSPLAKYHRSDAGLCERFEAFVATKEICNAYTELNDIFDQRARFEEQARQKAQGDDEAQIIDENFCTALEYGLPPTGGWGMGVDRLVMFLTDSNTIREVLLFPHMKPEVQAAEPTVVKE
What are the official names of this protein?
Lysine--tRNA ligase, cytoplasmic, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.