PharMolix/UniProtQA huggingface dataset:
Protein: ACASE_DROME
Sequence: MGGMGGGGLLDIYAMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILWVFMAAFSLFYPKRYYPKFVKNDRKTFSWLMLLSAIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVSDQRVYRLGIRSTTVWAVAVFCWINDRIFCEAWSSINFPYLHGFWHIFIFIAAYTVLVLFAYFYVESELPQRQPLLKYWPKNEFEFGIPFISIRNPGKALRNTI
What is the function of this protein?
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
What are the official names of this protein?
Alkaline ceramidase, AlkCDase, Alkaline N-acylsphingosine amidohydrolase, Alkaline acylsphingosine deacylase, Protein brainwashing.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_STRP2
Sequence: MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIVKAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL17_PROMA
Sequence: MRHQLRVPQLGRPADQRKALLRGLTTQLIREGRVTTTKTRAKALRDEVERMIGLAKDGSLAARRRAIGYIYDKKLVHSLFEKAQERYGDRQGGYTRIVRTVPRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: CTTB2_SAIBB
Sequence: MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKQRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTESADHVKKLPLTMPVKPSTGSPLASANAKGSAAMARPGIDRQTSHGDLIGVSVPAFPPSSANRIEENGPSTGLTPDPTSSTPPLPGNAAPPTAQTPGITPQNSQAPPMHSLHSPCANASLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTGPQAGAPPRPGAPPTGDVSTHHSVGRTGVKTHGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTGAKGDNKTVASPPSSLPQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCTVSALATSQVGAWPAATPGLNQPACSGSSLAIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLLMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTDRNVKTTDGWTPVHAAVDTGNVDSLKLLMYHRVPAHGNSFSEEESESGVFDLDGGGESPEGKSKPVVTADFINHANREGWTAAHIAASKGFKNCLEILCRHGGLETERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIEPSNYGSDDFECENTICTLNIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDVTCNNSTDSNIGLSSRSIRSITLGNVPWSVGQSFLQSPWDFMMKNKAEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVRQLALCLKHRQMAAGFSCEIVRAEVDAGFSKKQLLDLFISSACLIPVKQSPVKKKIIIILENLEKSSLSELLRDFLAPLENRSAESPCTFQKGNGMSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFRGQVPPPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVITPRVQEAILSRASVKRQPGLGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELEQHRADFKGGSFPLSIVASYNSCSKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGIKSKTLSQLNCNRNASLSKQKSLENDVSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFDSAGNNPVFSAAINNLRMPVSQKEVCPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVTQCSQNTKRNSSSSNTRQIEINNNSKEENWNLHKNEHLEKPNK
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: RL4_UREP2
Sequence: MAKIKLLSIDGNFAKELEVTSDLFVEVPHKQAMFDSVLAENAAERQGTHSTLTKGEVRGGGKKPWRQKHTGKARTGSTRNPHWTGGGVVFGPKPNRNYNLKVNAKVRLLAFKSALTIKLNEGKMLGLVANSDLETPSTKKMVNFINNANLENQKVLLVIVDNFSNIKKSTNNLQKVTTKLWYQVSVRDLMHANVVVVAEEAFTNYARKVSK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: F16PA_YERPA
Sequence: MKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPFGTPITEEDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMYSINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLAEQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_BACLD
Sequence: MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNLRTGAIQEKTFRAGEKVARAQIETKTMQYLYANGDQHVFMDTTSYEQLELNEKQIEHELKFLLENMSVQIMMYQTETIGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVVNVPFFVNEGDTLVVNTSDGSYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATRX_RABVS
Sequence: MNLLRKIVKNRRDEDTQKSSPASAPLDDDDLWLPPPEYVPLKELTGKKNMRNFCINGRVKVCSPNGYSFRILRHILKSFDEIYSGNHRMIGLVKVVIGLALSGSPVPEGLNWVYKLRRTFIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVIAKQCHIQGRVWCINMNPRACQLWSDMSLQTQRSEEDKDSSLLLE
What is the function of this protein?
Plays a major role in assembly, budding and uncoating of virion after membrane fusion (PubMed:33208464).  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication.  Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (PubMed:12771432, PubMed:9847327).
What are the official names of this protein?
Matrix protein, Phosphoprotein M2.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host cytoplasm.
Protein: THAS_PIG
Sequence: MEVLGFLSPELNGPMVTMALAVVLLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLTFFRQGFWESHMELRKQYGPLSGYYLGRRMIVVISDPDMIKQVLAEKFSNFTNRMATGLESKPVADSILFLRDKRWEEVRSVLTSAFSPKKLNKLTPLISQACDLLLAHLERYAESGDAFDIQRCYCCYTTDVVASVAFGTQVNSSEEPEHPFVKHCRRFFAFSVPRLILVLILSFPSIMVPLARILPNKKRDEVNGFFNKLIRNVIALRDQQAAEERRQDFLQMVLDLRHSAPSVGVENFDIVRQAFSSAKGCPADPSQPHLPRPLSKPLTVDEVVGQAFLFLIAGYEIITNTLSFVTYLLATNPDCQEKLLREVDDFSKKHPSPEHCSLQQGLPYLDMVLSETLRMYPPAFRFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHWPHPETFDPERFTAEAQRLQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPETQVPLQLESKSALSPKNGVYIRIVPR
What is the function of this protein?
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:3745158).  Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage.  12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2.  Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (By similarity).
What are the official names of this protein?
Thromboxane-A synthase, TXA synthase, TXS, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYT_MYCA1
Sequence: MTVPATDSWPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDAEVVPVAANTDEGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPEDLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYKLELVDDKSGDPDIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTAWESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYSRRKHIEAGYEFVNTPHITKAQLFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYYLKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTMDDSHIFCTREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEMWEQATTSLADVAAESGLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRPVMIHRALFGSIERFFGILTEHYAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSHGVRVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVSFRFGDRTQINGVPRDSAVDAIVKWIADRENSVPSAELVKVSSGE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAS3_STRTR
Sequence: MKHINDYFWAKKTEENSRLLWLPLTQHLEDTKNIAGLLWEHWLSEGQKVLIENSINVKSNIENQGKRLAQFLGAVHDIGKATPAFQTQKGYANSVDLDIQLLEKLERAGFSGISSLQLASPKKSHHSIAGQYLLSHYGVDEDIATIIGGHHGRPVDDLDGLNSQKSYPSNYYQDEKKDSLVYQKWKSNQEAFLNWALTETGFNSVSQLPKIKQPAQVILSGLLIMSDWIASNEHFFPLLSLDETDVKNKSQRIETGFKKWKKSNLWQPETFVDLVTLYQERFGFSPRNFQLILSQTIEKTTNPGIVILEAPMGIGKTEAALAVSEQLSSKKGCSGLFFGLPTQATSNGIFKRIEQWTENIKGNNSDHFSIQLVHGKAALNTDFIELLKGNTINMDDSENGSIFVNEWFSGRKTSALDDFVVGTVDQFLMVALKQKHLALRHLGFSKKVIVIDEVHAYDAYMSQYLLEAIRWMGAYGVPVIILSATLPAQQREKLIKSYMAGMGVKWRDIENIDQIKIDAYPLITYNDGPDIHQVKMFEKQEQKNIYIHRLPEEQLFDIVKEGLDNGGVVGIIVNTVRKSQELARNFSDIFGDDMVDLLHSNFIATERIRKEKDLLQEIGKKAIRPPKKIIIGTQVLEQSLDIDFDVLISDLAPMDLLIQRIGRLHRHKIKRPQKHEVARFYVLGTFEEFDFDEGTRLVYGDYLLARTQYFLPDKIRLPDDISPLVQKVYNSDLTITFPKPELHKKYLDAKIEHDDKIKNKETKAKSYRIANPVLKKSRVRTNSLIGWLKNLHPNDSEEKAYAQVRDIEDTVEVIALKKISDGYGLFIENKDISQNITDPIIAKKVAQNTLRLPMSLSKAYNIDQTINELERYNNSHLSQWQNSSWLKGSLGIIFDKNNEFILNGFKLLYDEKYGVTIERLDKNESV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity.  Functions as a ssDNA-dependent ATPase; dsDNA, ssRNA do not stimulate ATPase activity, while other nucleotides (aside from dATP) are not hydrolyzed.  Functions as a ssDNA nuclease; activity does not require ATP.  Functions as an ATP-dependent helicase; helicase activity requires hydrolysable ATP.  Unwinds both DNA/DNA hybrids and RNA/DNA hybrids, moving mostly in a 3' to 5' direction.
What are the official names of this protein?
CRISPR-associated nuclease/helicase Cas3.
What is the protein family that this protein belongs to?
In the central section; belongs to the CRISPR-associated helicase Cas3 family.
Protein: Y681_MANSM
Sequence: MKKRGKKPELDWETEEQEEIIWVSKSEIKRDAEELKKLGAKLVDLTKTNLDKIPLDGNLLEAVELARRSVKEAKRRQLQYIGKLLRNTDVEPIRDALDKIENKHNQQQAMLHKLELMRDELVSKGDEGLVALLIDYPQMDRRHLRNLIRSAQKEKEQNKPPKAYREIYQYLKDFIIEE
What are the official names of this protein?
UPF0307 protein MS0681.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: VL2_HPV69
Sequence: MVAVRASRRKRASATDLYKTCKAAGTCPPDVIPKIEGSTLADKILQWSGLGIFLGGLGIGTGTGTGGRTGYIPLGGGGRPSVVDIGPTRPPIIIEPVGPTEPSIVTLVEESSIIQSGSPFPNFSGGDGFEVTTSSTTTPAVLDITPSPGTVHVTSTNIQNPLYIEPPVDIPQSGEALGHIFTSTSTAGTHSYEEIPMEVFASNTSSGSKPISSTPIPGIRRVAAPRLYSKAYQQVKVTDPNFISKPSTFITFDNPAYEPMDTTLTFSADSHVAPDPDFLDIIALHRPALTSRRGTVRFSRLGQKATLKTRSGKQIGAKVHYYHDISPIHATEEAIELQPLITSEQHSTPLFDVYADADPAPTFTFPSTTPTTIPRFSSTIFSTTSSAPLNVTIPLSTSFDIPIYNGPDIYAPVPSSTWPYIPPPPTTMSHSVVAQGGNYYLWPYIYLIHKRRRKRVPCFFSDGLAAY
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RL9_LACE2
Sequence: MDVILLEDVKTLGKKGQIVKINDGYARNYVLPKKLGIEATAKNLNDLKLARKREEKEAAEELAAAKELAAKIKECTVTVSMKTGEGGRTFGTVSTKEVAEEAKKQLGLDIDKKKMKLDVPIKALGNYIIQIKLHKDVTAELTVKVVEK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RL16_PSE14
Sequence: MLQPKRTKFRKQMTGHNRGLALRGSKVSFGEFALKSVARGRLTARQIESARRALTRHVKRGGKIWIRVFPDKPVTKKPLEVRMGKGKGNVEYWVAQIQPGKVLYEIEGVTEELAREAFALAAAKLPLATSFVKRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CH60_CAMJR
Sequence: MAKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVELKDSLENMGASLVREVASKTADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMDKACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNLIADAMEKVGKDGVITVEEAKSINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQKTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRTLESATIQDLGQASSVIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYDREKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIKAKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAKGEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ8_CAEEL
Sequence: MAAKRPPASTLKWCQQEMGPICEGIGMVVRSQIGYDGRRIEKQIRRKALQTVVMGGQDVDPLKEPNKTNAPLLSPTLPSTNEALQRARVVAAGIETFAKLMSQGTYPGSAGFTVSETGERKYMKQTSPVQSNIVANLMATADKLSKGVISLAPFPLPTITKLGTWVIANPTAQLPIPPQLKSAIPAIGQIETLIQSILGVQGPVSSVSRAPRKLKLEGVTDQVVLEPETIHATVDVEPIDKTLTKEEAEFLIKAARSVDDDNAETAIFGTQKAKPKVYRPELPKNFEVNLEMGNVHTLTRSNESSVPATRIGRLATFGQLAFGLLGGATAEVTRRTFGIGKRLQEEGIPKNPFLSEANADRIVATLCRVRGAALKLGQMLSIQDSSTVPPALLQIFERVRQSADFMPIKQVHRQMKDAFGDDWREKFEHFDDKPFACASIGQVHKAVLKDGRNVAVKVQYPGVAEGIDSDIDNLVSVLSVGGIFPKGMFLDAFVGVARRELKQECDYEREARAMKKFRELIADWQDVYVPEVIDELSSSRVLTTELVYGKPVDACVEEPQVVRDYIAGKFIELCLKEIFLWRFMQTDPNWSNFFLGKHPKTGEPRLVLLDFGASRAYGKKFVDIYMNIIKSAYDGDKKKIIEYSREIGFLTGYETSVMEDAHVESVMIMGETLASNHPYNFANQDVTMRIQKLIPVMLEHRLTSPPEEIYSLHRKLSGCYLLAAKLKATVSCGGLFHEIHENYVFGEDGIDINID
What is the function of this protein?
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.  Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway.
What are the official names of this protein?
Atypical kinase coq-8, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RHG12_MOUSE
Sequence: MAERSGKITAGQAYIEVEYDYEYDAKDRKIVIRQGERYLLVKKTNDDWWQVRPDENSKAFYVPAQYVKEVTRKALMPPVKQATGLPNNSMKTIQSMHLQRSTENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERIQQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLCLPENESPPTSSKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEETPDSPGVEKHDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 12, Rho-type GTPase-activating protein 12.
Protein: TRUA_NEIMA
Sequence: MDTAQKQRWAITLSYDGSRFYGWQKQADGVPTVQAALETALAQIAGEAVSTTVAGRTDTGVHATAQVVHFDTTAARPQQAWVRGVNAHLPEGIAVLHARQVAPEFHARFDAYGRHYRYLLESAPVRSPLLKNRAGWTHLKLDIEPMRRAAAYLIGEQDFSSFRAAECQAKSPVKTIYRADLTQSAGLVRLDLHGNAFLHHMVRNIMGALVYVGSGRLSVEGFAALIQERSRLKAPPTFMPDGLYLTGVDYPEAYGIIRPQIPEWL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PCP_STAHJ
Sequence: MKILVTAFDPFGGEKINPALEAVKQLENTIGEHTISKLEIPTVFHESKDVIDKELANGNYDVVLSIGQAGGRYDLTPERVGINIDDARIPDNKGNQPIDVAIQEDGAPAYFSNLPVKTMTEAIKAAGVPASLSNTAGTFVCNHVLYQLGYLADKSYPGLLFGFIHVPFIPEQVTDKPEKPSMSIETIAKGLTAAIKAISKEDDAKVALGETH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFX1_HUMAN
Sequence: MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVICSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRLAEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD
What is the function of this protein?
Binds to the X-box motif of MHC class II genes and represses their expression.  May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma.  Isoform 3 binds to the X-box motif of TERT promoter and represses its expression.  Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression.  Mediates E2-dependent ubiquitination.
What are the official names of this protein?
Transcriptional repressor NF-X1, Nuclear transcription factor, X box-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the NFX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRIP6_MOUSE
Sequence: MSGPTWLPPKQPEPSRLPQGRSLPRGALGPPTAHGATLQPHPRVNFCPLPPEHCYQPPGVPEDRGPTWVGSHGTPQRLQGLPPDRGIIRPGSLDAEIDSLTSMLADLDGGRSHAPRRPDRQAFEAPPPHAYRGGSLKPSGGAVPTPMLPASHYGGPTPASYATASTPAGPAFPVQVKVAQPVRGCGLPRRGASQASGPLPGPHFPLTGRGEVWGAGYRSHREPGPGVPEGPSGVHIPAGGGRGGGHEPQGPLGQPPEEELERLTKKLVHDMSHPPSGEYFGRCGGCGEDVVGDGAGVVALDRVFHIGCFVCSTCRAQLRGQHFYAVERRAYCESCYVATLEKCSTCSEPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
What is the function of this protein?
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness.  Involved in lysophosphatidic acid-induced cell adhesion and migration.  Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity).
What are the official names of this protein?
Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Zyxin-related protein 1, ZRP-1.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. Colocalizes with actin.