PharMolix/UniProtQA huggingface dataset:
Protein: S26A5_RAT
Sequence: MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGDKLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYTVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAIIMGARRKAMRKYAKEVGNANIANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTTFPEELQRFLPQGENIHTVILDFTQVNFMDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTSNRFFENPALKELLFHSIHDAVLGSQVREAMAEQETTVLPPQEDMEPNATPTTPEA
What is the function of this protein?
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.  Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates.  It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate.  After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage.  They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization.  As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane.  The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state).  So, it acts as an incomplete transporter.  It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space.  Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
What are the official names of this protein?
Prestin, Solute carrier family 26 member 5.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Lateral wall of outer hair cells.
Protein: NRDR_CERSK
Sequence: MRCPFCGNIDTQVKDSRPAEDHVSIRRRRFCPACGGRFTTYERVQLRDLVVIKSSGKREDFDRTKLERSIRIAMQKRPIEPERIDQMISGIVRRLESLGDTDIPSKVIGEIVMESLARIDTVAYVRFASVYKNFQAADDFDKFVSELRPSAPAEE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PDRP_PELUB
Sequence: MSNTYQIYLISDSTGETLDRVFLAIKAQFKNIKYDVKSYFFTRTENQVSKIMDEAKKNDNAIILYTIVDTSLAKFLANKGDEKKIPCFSVLGNLIMNFSKLLNQKASHVPSGQHALNEEYYERIEAIQFTMAHDDGNLVEDVDKADLILLGVSRTSKTPTSIYLANRGYKTLNIPLVNEQSIPESLKKNPKLSCVVGLTTEPQRLVDIRKNRMNALKEKENTNYTNINKIEKEINEAKKTFIKYKWPTIDVTRKSVEETAASIIKIYEINKNNG
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: YQGF_RIPO1
Sequence: MERISALGLDIGKKRIGVAGCDGTGLIATGLTTIERTSFQSDVEQLHQWVKEREAQILVVGLPYSMDGSLGFQAKQVQKFTRRISHVLQLPVEYVDERLTSVEAEAQLKSQKRFSTWDKGAIDRQAATIILQQWLDSRR
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_ECOBW
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: IPKA_RAT
Sequence: MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEDDGQRSSTEQSGEAQGEAAKSES
What is the function of this protein?
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
What are the official names of this protein?
cAMP-dependent protein kinase inhibitor alpha, PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform.
What is the protein family that this protein belongs to?
Belongs to the PKI family.
Protein: BIOF_SHIFL
Sequence: MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWKQGAEQFGIGSGGSGHVSGYSVVHQALEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIVADRLSHASLLEAASLSPSQLRRFTHNDVAHLARLLASPCPGQQLVVTEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRRDEGDARREKLVSLIARFRAGVQDLPFTLADSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: NHAA1_FRAAA
Sequence: MLNPQTRRVRLFARGSWAETRRIAGILRDETISGGLLLAATVLALGWANSPWSGTYDSLLATDFGPAALHLDLSVQQWAADGLLAIFFFVAGLELKREFVAGDLRDPSRAVVPVAAAAGGVAVPAVLYSLLNLHSGALRGWAIPTATDIAFALSVLAVVGRCLPTALRTFLLTLAVVDDLLAIVIIAVAYTGELSVVPLVAAVVPLAAFTLLVQRRVRAWWLLLPLAVLTWALVHASGVHATVAGVLLAFAVPVLRSEGAGGPQAGPGLAEHFEHRWRPLSAAVAVPVFAFCSAGVTVGGLGGLGDALSDRAALGVVVGLVVGKAIGIFTTTWLVARFTGASLERGLAWVDVAGLALLGGVGFTVSLLIGELAFGPGSARDDHVKVGVLTASVTAALLATVVLRLRNRAYARIHELETADDDHEDGPDA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AR279_ARTOA
Sequence: MRFTLYGLLGFASLLHAAPIAENLSTTLKSLNVNPADFSLWDQRNFLGNPRLTCVVLEKLFGSKSTGVYESGYTALTEITWSQTCWVNPACIVSPANAQDVSKAIIVLRALQTKFSVRSGGHMANPGFSSAGPDAVLISLSNLTKLSLSSDKSIATIGVGNRWGAVYNYLQPYNVTVIGGRIGTVGSALVLGGGLNYFSGQFGLSADTVERFQVVLSDGSIVTATRTKNSDLFQALKGGSANFGIVTEFDLRTRYSGPLYYEAVLYPGDQYPALMKALVEYQRNGSLDTKASLVTSFRVEGNLVVFLYLDPVIRPSAFDPFYSVPSIPFFPPGFATITELVAALGIGFSSEPERDATRVTSFETDESILNYSYGIWQQVVATLPANASLEWVPQPIGAGLKAKGDQYGGNILGLPAKNHIWLDIVAKWKNPADDAFVLNASKFILDKTDAFAKSKNKYLPYLFMNDAYADQKVLRSYGTTNFNKIVQVSKKYDPSQTFQKLQGNGYLWTRE
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of sesquiterpenyl epoxy-cyclohexenoids (SECs) such as anthrobotrisins and arthrosporols, metabolites that possess a novel hybrid carbon skeleton consisting of a polyketide-derived epoxycyclohexenol combined with a terpenoid-derived monocyclic sesquiterpenol substructure (PKS-PTS hybrid) (PubMed:33823587).  The SEC pathway plays an important role for fungal soil colonization via decreasing fungal nematode-capturing ability (PubMed:33823587).  Within the pathway, the FAD-dependent monooxygenase AOL_s00215g279 plays a role in the oxygenation of the phenol moiety, most likely in the epoxy formation (PubMed:33823587).  The pathway begins with the biosynthesis of 6-methylsalicylic acid (6-MSA), the first precursor of the polyketide-derived epoxycyclohexenol in arthrosporols, by the polyketide synthase (PKS) AOL_s00215g283 via condensation of 1 acetate and 3 malonate units.  The 6-methylsalicylic acid decarboxylase AOL_s00215g281 then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol.  The cytochrome P450 monooxygenase AOL_s00215g282 further oxidizes m-cresol to yield toluquinol.  With the assistance of the oxidoreductase AOL_s00215g277, the polyprenyl transferase AOL_s00215g276 catalyzes the farnesylation of toluquinol to produce farnesyl hydroquinone, the hybrid precursor for biosynthesis of SECs.  Farnesyl hydroquinone undergoes epoxidation and then subsequent dehydrogenation to form farnesyl epoxy-quinone, the first and simplest SEC.  The cytochrome P450 monooxygenase AOL_s00215g278 and the FAD-dependent monooxygenase AOL_s00215g279 might be involved in the oxygenation of the phenol moiety, most likely in the epoxy formation.  The cytochrome P450 monooxygenases AOL_s00215g274 and AOL_s00215g280 are involved in specific regional ketone reductions at respectively C-4 and C-1 of farnesyl epoxy-quinone PubMed:33823587 (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase AOL_s00215g279, Sesquiterpenyl epoxy-cyclohexenoids cluster protein AOL_s00215g279, SECs cluster protein AOL_s00215g279.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: NDHI_POPTR
Sequence: MFPMVTGFMNYGQQTVRAARYIGQSFMTTLSHVNRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWELETNIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYNRHELNYNQIALGRLPMSVIDDYTIRTILNSPQSLIKMVKPPLIKD
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS6_MYCS2
Sequence: MVILDPTLDERTVAPSLETFLNVIRKDGGTVDKVDIWGRRRLAYEIAKHAEGIYAVIDVKAEPATVSELDRQLNLNESVLRTKVLRTDKH
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MRAY_MYCTU
Sequence: MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VAP1_STRPU
Sequence: TDIGGGLDVGGGLRGGLDIDAKGPDVDIKGPKVGGDISGPDLDVSGPDLDIDGGGKKGKGGFGFGLKMPKFGFGGHGKGDIDVDADVDIERPDLDVSGDADLPSGGVGLDVGGGIGGGLGGGLDIDANGPDVDIKGPKVGGDISGPDLDVSGPDLDIDVDGKKKGKGGFGFGMKMPKFGFGGHGKGDIDVDADVDIERPDLDVSGDADLPSGGVGLDVGGGIGGGLGGGLDIDANGPDVDIKGPKVGGDISGPDLDVSGPDLDIDVDGKKKGKGGFGFGLKIPKFMDPTFGFGGHGKGDIDVDADGGVVIPEGDIKVKTGKPDIGGDVDLPSGGVDLDVGGGIGGGLGGGLDIDAKGPDVDIKGPRVGGDISGPDLDVSGPDLDIDGDGKKKGKGGFGFGLKMPKFGFGGHGKGDIDVDADVDIERPDLNVSG
What is the function of this protein?
May function as a multidomain RNA-binding protein.  May play a role in nuclear RNA processing and in early development.
What are the official names of this protein?
Vesicle-associated protein, VAP-1.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Initially a peripheral membrane protein associated with the microsomal membrane fractions. May be targeted to the nucleus later in development.
Protein: NOL3_MOUSE
Sequence: MGNVQERPSETIDRERKRLVETLQADSGLLLDALVARGVLTGPEYEALDALPDAERRVRRLLLLVQSKGEAACQELLRCAQQTVRMPDPAWDWQHVGPGYRNRSYDPSCPGHWTPEAPSSGTTCPELPRASEQEEVGGPEGSEALQPRTPEEPELEAEATEGDEPDLEQEMNPEQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPDFQEEDESEDS
What is the function of this protein?
Apoptosis repressor that blocks multiple modes of cell death.  Inhibits extrinsic apoptotic pathways through two different ways.  Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity).  Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity).  Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627).  Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity).  Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity).  Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity).  Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (PubMed:24440909).  Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (PubMed:22082675).  Inhibits too myoblast differentiation through caspase inhibition (By similarity).
What are the official names of this protein?
Nucleolar protein 3, Apoptosis repressor with CARD.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Sarcoplasmic reticulum. Membrane; Lipid-anchor. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress.
Protein: SYI_STAAR
Sequence: MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFNVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQHPFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRQDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETVNHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLETRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVHLADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNASEFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVDELTHLCPRCQQVVKSLV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_BIFLD
Sequence: MNLAYIPSPTFSKFEIGPFTIHMYAICILIGICVAVWILTTRWKRYGGTFDQILDTTLVTVPCALVGARLYHCITTPADYFPPTGNLVNILKVWEGGMAIFGGISVGTLVAFLWCRHKHYPFAIFADAIAPALPVAQAIGRLGNWFNQELYGWPTTLPWGLKLNDADAIGKSEICYSGAQCPDYRTTLFHPTFLYEMIWNLIGAALIIYLGHKLADRLKAGQQFAMYLMWYGLGRTWIENVRINYSTVILGLRTNVWTAIIVFVLGCILFVVLYQYGPDPKAQARGLAAVTADELERQSIEEEQLRQKKQAKRTK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2766_ARATH
Sequence: MAMMTTTTTTFFHPLLPANTYKSGAVASSFVSVPRSSSLQFRSLVSDSTSICGPSKFTGKNRRVSVTVSAAATTEPLTVLVTGAGGRTGQIVYKKLKERSEQFVARGLVRTKESKEKINGEDEVFIGDIRDTASIAPAVEGIDALVILTSAVPQMKPGFDPSKGGRPEFFFDDGAYPEQVDWIGQKNQIDAAKAAGVKQIVLVGSMGGTNINHPLNSIGNANILVWKRKAEQYLADSGIPYTIIRAGGLQDKDGGIRELLVGKDDELLETETRTIARADVAEVCVQALQLEEAKFKALDLASKPEGTGTPTKDFKALFTQVTTKF
What are the official names of this protein?
Uncharacterized protein At2g37660, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YEI5_YEAST
Sequence: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKVVISVMVGKNVKKFLTFVEDEPDFQGGPIPSNKPRDGLHVVSSAYFEIQ
What are the official names of this protein?
Uncharacterized protein YEL075C.
Protein: RF1_LACP7
Sequence: MFDKLEDLLIRFQEIQNELNEPTVTNDQARFRKLMKEQNDLGEIVDKYLEYKQTKKNIEESLELLDEESDEEMRELAKEELSTSKANLVVIEEQLKILLLPKDPNDSKNVIVEIRGGAGGDEAALFAAELFRMYSKYAETMRWKIDMMNLNENGIGGFKEVIFMINGQGAYSKLKYESGVHRVQRIPVTESGGRIHTSTVTVAIMPEAEEVDVELNMNDCRFDVFRSSGNGGQCVNTTDSAVRLTHMPTGIVISCQDEKSQLKNRDKALKVLRARLYELELEKAHDAEAAARKSQVGTGDRSEKIRTYNFPQGRCTDHRIKLTSHRLDDIMNGDLQEVIDSLTAADQAAKLSNMQDEY
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HV459_HUMAN
Sequence: MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 4-59, Ig heavy chain V-II region NEWM.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: MID51_PONAB
Sequence: MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPQLLNRDMKTGLSRSLQTLPTDSSAFDTDTFCPPRPKPVARKGQVDLKKSRLRMSLQEKLLPYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDVYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPEEIDELGYTLYCSLSEPEVLLQT
What is the function of this protein?
Mitochondrial outer membrane protein which regulates mitochondrial fission.  Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins.  Regulates DNM1L GTPase activity and DNM1L oligomerization.  Binds ADP and can also bind GDP, although with lower affinity.  Does not bind CDP, UDP, ATP, AMP or GTP.  Inhibits DNM1L GTPase activity in the absence of bound ADP.  Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP.  Does not require ADP for its function in recruiting DNM1L (By similarity).
What are the official names of this protein?
Mitochondrial dynamics protein MID51, Mitochondrial dynamics protein of 51 kDa homolog, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like.
What is the protein family that this protein belongs to?
Belongs to the MID49/MID51 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.