PharMolix/UniProtQA huggingface dataset:
Protein: SPERI_MOUSE
Sequence: MSLLTSYEGLRHQIERLVRENEELKKLVRLIRENQELKSAIKTQAGGLCISGFTGGLGEAAAGPPQHQGVFLPPASAAAKEPCSEDLGMVALAPLADMLNTPQLSPAAGSLVNPLAATLNPLLSGQIPLLQNNQFANLVPCSMSNQLTNPTTVSPGVTLASSLGLPSTGPLNSQMTSPMTVPPGTTLASSLGLTSTGSLTTSSRLVGPLAVSQSSPIMAPLAGTVAVSLSSPLLSSTATPLGVAQNVVPNPINNIGQPETPRVRRAEPTRGNFSGTSAYAGPAPTSKVNDTRGSRVMEQSRKNVVEMERKTPHRKSNKLPDNPRDTKQLVCERLVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSNHKLDEDLCQTLTQRYVSIMNKLQSLGYNGRVHPALTEQLVNEYGILRERPELAASEGGCYTVDFLQRVLLETVHPSKLTDALLLLSCLHQLSHDDGKPMFIW
What are the official names of this protein?
Speriolin, Spermatogenesis and centriole-associated protein 1, Spermatogenic cell-specific Cdc20-binding protein.
What is the protein family that this protein belongs to?
Belongs to the speriolin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the centrosomal pericentrin protein PCNT1. Located in the connecting piece of sperm.
Protein: GLR13_ARATH
Sequence: MERFCIQTQTLLSFLLVLLLFISRSFASTKNDDVDGGKRVQIRVGLVLDLGSLKGKIVKNSVSMALSYFYAIHNDYKTRVSVSLRNSHGEPLLALASAVDLLKTEGVEAIIGGNSLLEAKLLGELGEKARVPMISLDSPFSLSLSKYTHLIQATHDSTSEAKGITSFINVFDWNSVALVYEDHDDWRESMQLLVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQLKDLGTTVFVVHLSEVIATHLFPCARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKSYIPMSIELQNFTLRWRKSLPVEEAELTRLSISGIWAHDIAFALARAAEVIRMPNVTSTLLEEITKTRFNGLSGDFQLNDKKLLSNKFEIINMIGSSERRVGFLNSNGSFSNRRHLSSTHNKLETIIWPGGSAQSPKGTSLIDSDRKKLRVLVTSSNRFPRLMKVETDPVTNELIVEGFCIEVFRASISPFNYEVEYIPWLNGSNYDNLAYALHSQKDKYDAAVGDITITSNRSTYVDFTLPFTEMGLGIVAVKERSMWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEFQGSWPQQIGVVLWFGFSTLVYAHREKLKHNLSRFVVTVWVFAVLILTASYTATLTSMMTVQQIRFNSNEDYVGHLSGSLIANVALTSSSLRAMRSLGLNSAADYAQALLNKTVSFVVDELPYLKVVLGENPTHFFMVKTQSTTNGFGFMFQKGFELVPNVSREISKLRTSEKLNEMEKRWFDNQLPYTTDDTSNPITLYRFRGLFIIIGVSFAFALAVLVILCLRDKWEILVDNLDLSQRLRHFRIHFVRSIHTSPLDDPIGETAVQMAQQNRQ
What is the function of this protein?
Glutamate-gated receptor that probably acts as non-selective cation channel.  May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
What are the official names of this protein?
Glutamate receptor 1.3, Ligand-gated ion channel 1.3.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ALR_LACLM
Sequence: MKTSPHRNTSAIVDLKAIRNNIEKFKKHINPNAEIWPAVKADAYGHGSIEVSKAVSDLVGGFCVSNLDEAIELRNHLVTKPILVLSGIVPEDVDIAAALNISLTAPSLEWLKLVVQEEAELSDLKIHIGVDSGMGRIGIRDVEEANQMIELADKYAINFEGIFTHFATADMADETKFKNQQARFNKIMAGLSRQPKFIHSTNTAAALWHKEQVQAIERLGISMYGLNPSGKTLELPFEIEPALSLVSELTHIKKIAAGETVGYGATYETSEETWIGTVPIGYADGWTRQMQGFKVLVDGKFCEIVGRVCMDQMMIKLDKSYPLGTKVTLIGRDKANEITTTDVADWRGTINYEVLCLLSDRIKRIYK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: ENO_ACIC5
Sequence: MTEIAAIHAREILDSRGNPTVEADVLLADGTLGRAAVPSGASTGEHEAVELRDGDKSHYLGKGVLKAVDNIESVIAPELEGMDAANQRLLDATMIALDGTPNKGRLGANAILAVSMAAARASANSLKIPLYRYLGGANASILPTPMMNILNGGAHADNNVDFQEFMVMPVGAERFSEALRWGAEIFHTLKGVLKKKGYNTAVGDEGGFAPSLSSNTEAIEVILEAIELAGYKAGEDVAIALDPAASEFYDKEKGKYIFKKSDKSEKTSEEMAQYWESWTRQYPIISIEDGFAEDDWQGWRYFTELVGSRIQLVGDDLFVTNTERLQRGIEEGIANSILIKVNQIGTVSETFEAIELGRRYGYTSIISHRSGETEDTFIADLAVATGAGQIKTGSASRTDRIAKYNQLLRIEEQLGQTGEFLGLEAVNFGE
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PRIO_COLGU
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: MSH3_SCLS1
Sequence: MGKPKSTPVKTQKSISSFFTPKSSQKPQNSSPPPASNAPENLYDAQSDQETNETAEITGNSSKRTLEEDANGGNTGATERPSKRAKNVDVEEEDGEGSSLPAANARKAPSSSMLGKSKPSTRTNKYMFSGLSQSVAAEPTIEEELEEESEKARKADLHRKFVKKLGHPDSIKRSIPEDDAALEGDEDMEDEEEAPAPVKTKKKGAKTGKLTPMELQVLDIKRKHMDTLLIVEVGYKFKFFGEDARTAAKVLSIVCIPGKFRFDEQAHLNYFASASIPVHRLPIHAKRLVAAGHKIGIVRQTETAALKKAGDNRNTPFVRKLTNVYTKGTYIDDIEGLDSTDAPSGGAPATGYLLCITETKAKGWGTDEKVEVGILAVQPATGDFIYDNFEDGFMRSEIETRLLHIAPCEFLIVGELTKATEKLVQHLSGSTTNVFGDRIRVERVEKPKTMAAESYSRVAQFYADKLKAHQSSNNAREQELLEKVLRLTEPVTICLSAMITHMTEYGLEHVFDLTKYFQSFSARSHMLLNGNTLTSLEIYTNQTDHTEKGSLFWTLDKTQTRFGQRLLRKWVGRPLLDKQRLEERVAAVEELKDNVNTPKVDKLNATLREVRSDLERSLLRIYYGKCTRPELLTVLQTMQRIANEFAHVKIPSDAGFDSVLLNEAVASLPEIGGVVISFLEKINAQAARKDDKYAFFLEEYETEEIGEHKCGIGAVEQDLEAHRKEAASKLSKKTPVTYVTIAGIEYLIEVPNSDLKKVPASWAKISGTKSNSRFHTPEVIKFLRERDQHKESLSSACDTAFLAFLAEISTHYALIRDTISQLATLDCLLSLAAVASLPGYCKPTFTSTTEISVVGGRHPMVEQLLPSTYIPNDTSLSTDPDNTRALLITGPNMGGKSSYVRQVALISILAQIGSHVPAESARLGLLDGIYTRMGAYDSLFTAQSTFMVELSETASILKSASPRSLVILDELGRGTSTHDGVAIAEAVLDWVVRETKCLCLFITHYQTLASVARGFEKGKELRNVHMRFTAERNGKQVSNANADKDGEDVNEEITFLYEVGEGVAHRSYGLNVARLARVPKAVLDTAASKSRELEAEVKQKKLLGLSKMISNVLENDVDQLEQLIIGMEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATG3_KLUMD
Sequence: MLRSTLSNWREYLTPITHTSTFETTGQLTPEEFVKAGDYLVHMFPTWRWNGTDYNNVSYKDFLPKEKQFLITRKVPCKLRASNFVETQTTETRDVGDGWELEGQSEGERESGREDTKSNEEALASNIEDLQIVDDDESEGGGDEEQLLQNELADDDDDIVDIKPSTLRYYDLYITYSTSYRVPKMYLCGFANEGTPLSPDQMFEDIAPDYRSKTATIEPLPFFKGNQISVSIHPCKHANVMKVLMEKVRASRHRARDTEAQKNAEEDWEDLQSDIDDGLRVDQYLVVFLKFITSVTPGIEHDYTMEGW
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy (PubMed:26442587).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8 (By similarity).  The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE) (By similarity).  This step is required for the membrane association of ATG8 (By similarity).  The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity).  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme atg3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFRA2_MOUSE
Sequence: MILANAFCLFFFLDETLRSLASPSSPQGSELHGWRPQVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYRTITSCPADNYQACLGSYAGMIGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNMSPKGPTFSATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLYSGSCRARLSTALTALPLLMVTLAQ
What is the function of this protein?
Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
What are the official names of this protein?
GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, GDNFR-beta, Neurturin receptor alpha, NRTNR-alpha, NTNR-alpha, TGF-beta-related neurotrophic factor receptor 2.
What is the protein family that this protein belongs to?
Belongs to the GDNFR family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: PROF2_MACFA
Sequence: MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-2, Profilin II.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HV01_CAICR
Sequence: MGLGLHLLVLAAALQGAWSQVQLVESGGDVRKPGNSLRLSCKASGFTFGGYGMFWVRQAPGKGLDWVATINTDGSSQWYSPAVQGKFTISRGNSQNMLYLQMSSLTPEDTATYYCAR
What are the official names of this protein?
Ig heavy chain V region C3.
Protein: Y528_YERPB
Sequence: MSDSLWHLYLLRTASGMLYTGITTDVARRLAQHQAGKGAKALRGKGELTLVFHCEAGDRSTALKLEYRVKQLSKQQKEKLVIDQPRLLTTLFLAS
What are the official names of this protein?
UPF0213 protein YPTS_0528.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: NB1_MYCTO
Sequence: MSSGAGSDATGAGGVHAAGSGDRAVAAAVERAKATAARNIPAFDDLPVPADTANLREGADLNNALLALLPLVGVWRGEGEGRGPDGDYRFGQQIVVSHDGGDYLNWESRSWRLTATGDYQEPGLREAGFWRFVADPYDPSESQAIELLLAHSAGYVELFYGRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLSARLSRFVG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 1, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: UL79_HHV6Z
Sequence: MTQIGQYIKLNDAVPNLILHITTKLLRNENLTSFKQEELLLIQHVCTSMLSHGIKILLLRESLYNSGIGDIVILNRKISNNYWFRLFSILKQHSDAELLRHMFNESHSAYISKKLHYSGNVSHIINFLFMDEFGLSLKIPEEIICEGNIVFSVGAIYNHRLLKICRFFNRFWGDQEREPAVRLICKHLWFAYLIMFGKFEISTLAYNQQRAEHKAGLFSFLQNDFKVFCGMSENPQLLDSSAIFDLTGISAEDLFSYE
What are the official names of this protein?
Protein U52.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL79 family.
Protein: HXA2_HETFR
Sequence: MNYEFEREIGFINSQPSLAECLTSFPPVGDTFQSSSIKNSTLSHSTVIPPPFEQTIPSLNPSSHPRQSRPKQSPNGTSPLPAATLPPEYPWMKEKKNSKKNHLPASSGPAASCLSQKETHEIPDNTGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNGDGKFKNLEDSGQTEDDEEKSLFEQGINNVTGALLDREGYTFQSNALTQQQAQNLHNGESQSFPVSPLPSNEKNLKHFHQQSPTVQNCLSTMAQNCAAGLNNDSPEALDVPSLQDFNVFSTESCLQLSDGVSPSLPGSLDSPVDLSADSFDFFTDTLTTIDLQHLNY
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A2.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Proboscipedia subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: WDR86_HUMAN
Sequence: MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFSNKVGCAAAPLQPA
What are the official names of this protein?
WD repeat-containing protein 86.
Protein: Y973_STAAT
Sequence: MILGLALIPSKSFQEAVDSYRKRYDKQYSRIKPHVTIKAPFEIKDGDLDSVIEQVRARINGIPAVEVHATKASSFKPTNNVIYFKVAKTDDLEELFNRFNGEDFYGEAEHVFVPHFTIAQGLSSQEFEDIFGQVALAGVDHKEIIDELTLLRFDDDEDKWKVIETFKLA
What are the official names of this protein?
Putative phosphoesterase USA300HOU_0973.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: SHE_MOUSE
Sequence: MRRPPAPGAPRCLSWASSLFCSAASTLPGPLMAAKWFKEFPLTLKTASERARPGGAGGKPRKNSETGGAAPTPGKGRKNSAAELGASKASSGPPKDSRLSRDSLQGLIQAAAGKGRKNSRVTATATEEEPHRGAVTKSAGCSTYISRLIKVDTQEKNGKSAYPGGGSTSSSSSSSSSASSSPSSLGPELDKAKIMRQQDTVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDGPSEPGETVKVEATAKRRSSKDLLGKPPQLYDTPYEPSEGGQRVAEVKTRPADSRLPEEDDRPAAEYEQPWEWKREQIARALSVQFEGSDRPPGREDAGRPHHWQKTLKPTLSDHGDGEKVDPGLALEKQPWYHGSISRAEAESRLQPCKEAAYLVRNSESGNSKYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNAKLPFKGAEHMTLLHPVHKLH
What are the official names of this protein?
SH2 domain-containing adapter protein E.
Protein: ILVC_MARN8
Sequence: MQVYYDKDCDLSIIQGKKVAILGFGSQGHAHACNLKDSGVDVVVGLRAGSSSIAKAEAYGLKTSDVASAVASADVVMVLTPDEFQAQLYREEIEPNLKQGATLAFAHGFAIHYNQIVPRKDLDVIMVAPKAPGHTVRTEFTKGGGIPDLIAIFQDASGNAKNVALSYASGIGGGRTGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFISEGALNYPSMTARRRQNAAHEIETVGEKLRSMMPWISANKIVDKDKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TIG_PECAS
Sequence: MQVSVETTQGLGRRVTITVAADIIESAVKSELVNAAKKVRIDGFRKGKVPMNVVAQRYGASVRQDVLGDLMQRNFVDAIIKEKINPVGAPNYTPGEYAVGGDFTYTVEFDVYPEVELKGLEAIEVEKPVVEVTDADVDTMLDTLRKQQATWKETDRAATAEDRATIDFTGSIDGEVFEGGKASDFVLAMGQSRMIPGFEDGIVGHKAGEEFTINVNFPEDYHAENLKGKAAQFVIVLKKVEERELPELTEEFIKRFGVADGSQEGLRAEVRKNMERELKGAVRNRVKTQVLDGLINANDIEVPVALIDGEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVIGLLLGEVISSNELKADEARVNVLIEEMASAYEDPQEVIEFYSKNKELLNNMRNVALEEQAVETVLAKAKVVEKSVSFNELMNQTTTA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LEPA_ECOHS
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AK_THET2
Sequence: MALVVQKYGGTSVGDLERIHKVAQRIAHYREKGHRLAVVVSAMGHTTDELIALAKRVNPRPPFRELDLLTTTGEQVSVALLSMQLWAMGIPAKGFVQHQIGITTDGRYGDARILEVNPARIREALEQGFVAVIAGFMGTTPEGEITTLGRGGSDTTAVAIAAALGAKECEIYTDTEGVYTTDPHLIPEARKLSVIGYDQMLEMAALGARVLHPRAVYYAKRYGVVLHVRSSFSYNPGTLVKEVAMEMDKAVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPDIAKVSIVGVGLASTPEVPAKMFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVHQAFELDKA
What is the function of this protein?
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.
What are the official names of this protein?
Aspartokinase, Aspartate kinase, ASK.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: NADK_STAA9
Sequence: MRYTILTKGDSKSNALKHKMMNYMKDFRMIEDSENPEIVISVGGDGTLLQAFHQYSHMLSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYETRYLALNEATMKTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASINNRVFRTVGSPLVLPKHHTCLISPVNHDTIRMTIDHVSIKHKNVNSIQYRVANEKVRFARFRPFPFWKRVHDSFISSDEER
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2327_PARP8
Sequence: MPKSNDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLQALFNRIDLKLEIEPLLHVPVYFGGPVQTERGFVLHDASENTYTSSMQVPGGLEMTTSKDVLEAVASGKGPERFLLTLGHAGWGAGQLEDEISKNGWLTVEADPKIVFDVPAENRFEAALALLGISSSMLSGDAGHA
What are the official names of this protein?
UPF0301 protein Bphy_2327.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: GLSA1_CLOPE
Sequence: MDINLDALVEANRRYTKEGHVATYIPALAKVNPDQLGVCIYDLKENKEFSAGEYDVRFAIESISKVPTLILAILDNGIEKVFSEVGTEPSGFAFNSIMNMQINHKNKPSNPFINAGAIKVVSLLKGKNDEERFKRILDFYRKIMNDDEITLDTEIYLSERETGDINRSLAYYMKGNGIMEGDVTDILDSYFKQCSVLVTAKDLARLGAVLANEGVMPWNGERLFSVETATVVKSLMTTYGLYDESGAFSVHIGLPSKSGVGGGILSSVPNKCGIGLFSPALDVSGNSVASMKLLKEIADKLKLDIFR
What are the official names of this protein?
Glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: HIS2_LEPBJ
Sequence: MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEAADLLFHLQVLLVEQELSLQDVVEELRKRHS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INT12_XENTR
Sequence: MAVTINTELDPVFLKALGYLHSKSKDSAEKLKALLDESLCKGNDSVYRPQPKEMEQPKAMLSKVKPETKASSSTPSSSMLSKPLTSEKLKKEAEKRSADKMKVEISDVMDIPKKPRIEKTEARSSPVTVQLSKDLPVPDLSSFDETSADDFAMEMGLACVVCRQMTVFSGNQLVECQECHNLYHQDCHKPQVTDKDVNDPRLVWYCARCTRQMKRMAQKNQKPSQKPSPSAVSAVTPVAKDPSVNKPELKAKPDSANTFLAFKRAEVKASSAVSSSSSNSGVSSSSASGLTGWAAFGAKTANAVPVLGKLGTSSQATSGKPPSLSSVQKTGAAPGLAPSKPGSVSKSGSGGSSSSSTIPIKPLPPLILGKTGLSRSMSSDNVSKTGLPSPNPSSAGSVSSLSSQLGSNNGSSSAAGSNVTSSNKVAVDPSMQLSGAKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
What is the function of this protein?
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 12, Int12.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PXPA_STAEQ
Sequence: MKLKIDLNCDLGEAFGNYTFGGDQHILPLITSANIACGYHAGDEDVMNETVQLAKKNNISIGAHPGLPDLKGFGRRKMDLTPNEIYNLVIYQLGALSGFCKINHVKMMHVKPHGALYQMGARNKEIAHAIAQAVFDFDSNLIFVGLANTLLISEAELVGLKVASEVFADRRYEDDGQLVSRKKTDATITNTDEAIQQALKMVLENKVVSKNGKIIDLKADTICVHGDGKHALEFVTQIRNELMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.