Protein: NPS6_GIBZE
Sequence: MTELDLSAEPNVPQTKTVRHNVPVLRKHHEQDAQELEILLLAWSLLLYRHNHGNHVEFSWGLTEIGSSTCRTFTLNTAKLQWDGSNIVASELEVFKTYTQQQLQSEVPFKRDQYKLFFNDEPATGDLVNYITEDGDISVNWGNVQIQATLVDDALCLRPTWREPLGAEFLANHLAQAFVEVLNTTLADPDATLSSVLPLGKLDKSVIWNWNKDLPPPVPECIHTLISEQVRLRPDAQAICSWDGDLTYAEMDNLSTLLAQHLINLGVKNGDIVPLCFEKSRWTTVGVMGVIKAGAAFVLMDPSQPIQRRQVMAQQVKATHILTSRDQAKYGPEIAPEAKHVIVDTETLDSLAKTIEDPSRELPQVPPESLLYIIFTSGSTGTPKGVMLSHETYTASALARSTGIGYSSISRSLDFTSYAFDVSIDSILCTLIRGGCLCIPTDMDRVNDLSGAIRRLKVNMVNITPSVARILDPDIIPSLNSLGIGGEACSAGDIAIWGQHTRIVIGYGPAECTIGCTVNPSAAGKPYVSMGPGTGACIWLVDPDDHNKLVPVGAVGELLIEGPIVGQGYLGDPEKTKEAFISDPDFLLAGADGIPGRQGRLYKSGDLVRYDPDGENGFIFVGRKDTQIKLRGQRVELGEIEHHIKNLLPSGAEVVAEIIAPRNQNKESMLVAFVADREAKDEGDARQIDFPPRFREALEVLNDKLSKVVPVYMVPTQYITLSKIPYLVSGKTDRKSLRALGAEISANMQASAAANESSEIREPQSEAELFLRDSWCRLLGLENKQVSTTHNFFTSGGDSVLAMKLVPIVRDWGYTLSVADIFNYPVLSDMANSMQKGDSSKGVDMQIPEFSLLKDDMDREALCAEAAHNSGCDVSAIEDIYPCAPMQEIHMAFYTRSKENYVAQRIADIPASSSIDKLKSAWNVVYKESPILRTRIVEFKQHGFMQVVVNEALQWEEVDSSLEDFIEKDKKESMSPGAPLSRFAIVTDKALDKRYFVWTAHHAIYDGWSTDLIVEHARAAYKGQEVSRPAQFKHFIRYLAEDSRESSKAYWKTQLAGATGPQFPSLPSRSYIPDPTSLTERFIKLDKAAKSDITIATVIRAAWALLASQYSMSDDVVFGETFMGRTIPLPGAELIEGPILATVPVRIRLDLTTTVQDFLRAVQEQSVKRAAHEHLGIQHIRRLSDDAQIACEVTMGLVVQPQDPDPTETENDALPSFRGGDAALEALHFNSYPLMLAVSMQKTGFRLLASFDSELLSHVQVERVLSQFEVAINQLRGDMSRSLNELTCLGEEELGQIWEANKHAPVSPKDISRFLSTGDKYPTVQYVPWVVQPGNEKLLMPLGSTGELLLEGIASAGDDDDVVDAPEWLKEGAMGYPGRQGKLVRTGDLVKYADDMSLVFIGRKDAMTSVDGRVVDLNATNIELNRLLPSNTKAVSRLVVPKGSNSQTPVVVALVQETSAKDTQLLKLGLDISDASMPLSQAVSVELATAIIGLNKAMVETLPPYAIPSICIPLDNSADIDSIDTIVENITLSLVVELRKSFASLKKTIADTTVLTTKERVLRASWSKFLGIEEEKLALDDNFFRLGGDSIVAMRMVSALRQDGYRLSVASIFQNMQLRGMADSLAEISTESVEAAKEYTAFSMLDTNDVDSFLAKVIRPQLADPKWKIKDVLHATGPQAGDVKQSVFAPRSSVQYNMLYLDQSIDTARLVDSFQYLVSQHAILRTVFVENEGQTLQVVLDDLKVPVTEQNVEGSIDAAAKQLAVSDINSSIDLTHGSSFIRLFVLRGESENALVIRISHAQYDGVSLPELLRQLELRYRGLEIPSSEPFETYIQHLSAAKPQNVEFWRKTLQGSSYTEIAPAADPQKKTAFMTKDVDISGASPNTTHAMLLTAGWAKVLSQHLNVSDVTFGGIVSGRDVDVAGIDTIMGPCYQYQPVRVKFESNWTATDLLDSVRSQSLEGSQRATLSFQEVLKECTNWPAGTPFYGSFTNHLNKEFFDSIPFAGTKCRVDYSIPHPEPATPPRVVSFLEDGRTQIGIEADEERREFWEARLGELAKVIEGFVKNPQALI
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875).  Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706).  The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875).  SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510).  The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).
What are the official names of this protein?
Nonribosomal peptide synthetase 6, NPRS 6, Extracellular siderophore synthetase.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.