PharMolix/UniProtQA huggingface dataset:
Protein: PNP_MYCPA
Sequence: MSVAEIEEGVFEATATIDNGSFGTRTIRFETGRLAQQAAGAVVAYLDDENMLLSATTASKSPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTILSLDPNDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVAFPTVEQLERAVFDMVVAGRKVDGADGPDVAIMMVEAEATSNVIELIDGGAQAPTETVVAQGLEAAKPFIEVLCTAQQELADKAARPTSDYPTFPDYGDDVYYSVASVATDELSKALTIGGKAERDARTDELKAEVLARLAETYEGREKEVSAAFRSLTKKLVRQRILTDHFRIDGRGITDIRALSAEVAVVPRAHGSALFQRGETQILGVTTLDMVKMAQQIDSLGPETTKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSLEDFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDIEVEAGDGTKSLERRFVTLTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLDGIPSQVLAGALSQAKDARLTILEVMAEAIDEPDEMSPYAPRVTTIRVPVDKIGEVIGPKGKIINAITEETGAQISIEDDGTVFVGATDGPSAQAAIDRINAIANPQLPTVGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIDKRGKISLVLVEEDNSAPADTPAAAPADATS
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDPAS_SULIK
Sequence: MSIAYDLLLSILIYLPAFVANGSGPFIKRGTPIDFGKNFVDGRRLFGDGKTFEGLIVALTFGTTVGVIISKFFTAEWTLISFLESLFAMIGDMIGAFIKRRLGIPRGGRVLGLDQLDFVLGASLILVLMRVNITWYQFLFICGLAFFLHQGTNYVAYLLKIKNVPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ESM3_DROME
Sequence: MVMEMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSETASVSSQESGASEPVWRPW
What is the function of this protein?
Transcriptional repressor of genes that require a bHLH protein for their transcription.  May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes.  Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation.
What are the official names of this protein?
Enhancer of split m3 protein, E(spl)m3, HLH-m3.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZBT11_HUMAN
Sequence: MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRRDLIEAAHLGPGGTHHTRHQTWHYLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDVSEMLEELGLDLESGEESNESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQNGEVGRQPEPQVSSEAESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKENVISSSPEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLRQRSVNEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEASHKCGECGMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGMQEQESSGPQELETVVVTGETMEALEAVAATEEYPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVKVEVAHISGGE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 11.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CD123_PHANO
Sequence: MANIENRVHWVILTLPRYRAVTPKARLVPLPAAFLDYLRSDGIILPPEDGDNPTWSDNDSGIFSGADNNDEDDEAAADPSVDWRDTHEAIERTIEELGGKVAPKLNWSAPKDATWMNATNSMECRTPNDIYLLLKSSDFVTHDLAHAFDDTADQSSEDDQEIPYHLVLRKWITLNPSVEFRCFVRDRRLIALCQRDLNHFDFLFNMQDKLRNAVQDFFELRLRNTFPDPNFTFDVYVPPPHDKVWLVDVNPWALRTDPLLFSWMELLTMDVPDVEQEETTVRLRLAQPGSSGRTGADESSGADDSEDDDIEEIWQPEFRLVRRDDPEAYGFATPQYSAHKLPKDVVDASKDGGGGMREFAQQWEEAQRLAEQQRAEDSETD
What is the function of this protein?
Regulates the cell cycle in a nutrient dependent manner.
What are the official names of this protein?
Cell division cycle protein 123.
What is the protein family that this protein belongs to?
Belongs to the CDC123 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1511_RHILW
Sequence: MAKRPVATSSDDELPFEIEEPVAADERAFFGGQPQKPAAANAKAALPASLAAQEHYHGHRERLRDRFREQGDTALADYEILELLLFRLIPRRDTKPIAKALIERFGSLAGVFGAPAALLTEVKGVGEAVALDLKLISTVAHRTLKSELRSKQVLSSWSSVIQYCHAAMAHETREQFRILFLDKRNVLIADEVQGRGTVDHTPVYPREVVKRALELSATAMILVHNHPSGDPTPSRADIDMTKVIIEAAKALDITVHDHVIIGKDGHVSLKGLKLI
What are the official names of this protein?
UPF0758 protein Rleg2_1511.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: HGH1_MOUSE
Sequence: MRGPGVGSGFSGERGLLEQEAGADTEAVELLPFLVLGARADLQAAAAQHVLALTGAGSGRTLLAGQPELLRALVDLAVAPAPAPSRDASRALVNLAADPNVHWQLLAADPELPARLLRCVLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLGLERLVNALCTPSYNAAAPLHYLGPLLSNLSQQAEVRAFLLDPDRCVVQRLLPLTQYTDSSVRRGGVVGTLRNCCFEHRHHKWLLGAQVDILPFLLLPLAGPEEFSEEEMDQLPVDLQYLSPDKQREPDADIRKMLIEAVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAGMENLLEVQVPEDVEQQLQELDQQEQQELAQELRGNGAPHT
What are the official names of this protein?
Protein HGH1 homolog.
What is the protein family that this protein belongs to?
Belongs to the HGH1 family.
Protein: RLMN_SALCH
Sequence: MSEQIVTPESSTPVVLNNETKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDTIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEVIDIKAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_BUCBP
Sequence: MKILPIKIKGSIFTLLVLYLQNHPVELFKNNLRDKIKNFPTLFKNAPIAINVEKCSNEINWNNIKNAIISCGFNIIGVSGCKNGKLKNNIIKSGLPILSEGKEVFNFFNNINLDDKILSFEKKNYNKTPIFNSPIRSGQKIYANNSDLIITNNVNSGAEVIADGNIHIYGEVRGRVLAGAKGDNTCQIFCTKLFSELVAISGEYLLSGDFSEDTIGNSVKIYMKNKKLHIVKLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: CR161_PHYSP
Sequence: MVKLSCVIVGVPGDPFQVEIDEICELVAGLKDAIKKEKPDSIKCDADKLQLFKAAKEDRTFSASGAEEEKKDFRWLKAASDDVKKLKHGEKTAAIEAVVRKDQVLRGKETVSDVLMGMESPSISQIHVLVVLPEDSESEGGTSAQPAEKERLLKFLREQAADKKRKRYWHSEMDMDQGWELLDDFDLTVKPVSTVHAEADPADSFNWQSDLVQDGQEVVLTEEQQRGRYREYVERNIGAVLKENKLCVTAVDEGENVLSVDVPKLGIELRGRTDLLVLSDIVEETSDYLMHLPEVKMLIEVKRDAEASDFQALSELIALDILAEDPVMALLTDLNQSWKFFWVSKKSDDSDCICKATIKSPGEAFQVIRALLTASAETKLPCFHQPLKRLKLSQHRGYKNAECLQQYYKVAEVSGPDYELARAVAEHLVRSMPGYCCANESEP
What is the function of this protein?
Secreted effector that exhibits strong cell death suppression activity and suppresses cell death induced by a variety of effectors including CRN63, Avh241 and Avr3a (PubMed:26546319).  Protects host plants from biotic and abiotic stresses such as salinity and drought by up-regulation of many defense-related genes, including ABC transporters, Cytochrome P450 monooxygenases and receptor-like kinases (RLKs) (PubMed:26546319).  Enhances also resistance to Phytophtora pathogens (PubMed:26546319).
What are the official names of this protein?
Crinkler effector protein 161.
What is the protein family that this protein belongs to?
Belongs to the Crinkler effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: STX6_HUMAN
Sequence: MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL
What is the function of this protein?
SNARE promoting movement of transport vesicles to target membranes.  Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking.  Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
What are the official names of this protein?
Syntaxin-6.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type IV membrane protein.
Protein: RL14E_PYRFU
Sequence: MPAIDVGRIAVVIAGRRAGQKVVVVDIIDKNFVLVTGAGLNKVKRRRMNIKHIEPLPQKIDIPRGASDEEVRAALEKAGISLA
What are the official names of this protein?
50S ribosomal protein L14e, Large ribosomal subunit protein eL14.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: GLYA_BORPD
Sequence: MFDRKLTLSQVDPEVWAAIQKEDVRQEQHIELIASENYASPAVMQAQGTQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRLKQLFGAEAANVQPNSGSQANQGVYMAVLKPGDTVLGMSLAEGGHLTHGASVNASGKLYNFISYGLDANEVLDYAQVEQLAKEHKPKLIVAGASAYALHIDFERLARIAHDNGALLMVDIAHYAGLVAGGAYPNPVPHADFVTSTTHKSLRGPRGGVIMMKAEYEKIINSAIFPGIQGGPLMHVIAAKAVAFQEALSPEFKQYAQQVAKNAKVLAETLVKRGLRIVSGRTESHVMLVDLRPKGITGKEAEAVLGQAHITVNKNAIPNDPEKPFVTSGIRLGTPAMTTRGFKEAEAELTANLIADVLDNPRDEANIAAVRARVNELTARLPVYGG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_NEOFI
Sequence: MGKKAIQFGGGNIGRGFVAEFLHEAGYEVVFIDVVDKIIDALKSTPSYEVSEVSEEGEKTKTITNYRAINSKTNEEDVVKEIGTADVVTCAVGPNVLKFIAPVIAKGIDARTASKPVAVIACENAIGATDTLRGFIEQHTDKDRLSSMSERARFANSAIDRIVPNQPPNAGLNVRIEKFYEWTVEQTPFGEFGHPDIPAIHWVDDLKPYIERKLFTVNTGHATTAYYGHVRGKKMIADALADAEIRKIVHNVLEQTAMLITTKHEITEQEQNEYVDTIVKRMSNPFLEDNVERVGRAPLRKLSRNERFIGPASQLAEKGLPFDALLGSIEMALRFQNVPGDEESAELAKILKEMSADEATGKLTGLEKSHPLYKPVQNVVAKVQKDSK
What is the function of this protein?
Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase, M1PDH, MPD, MPDH.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: TMM_ARATH
Sequence: MARYEFFRQIFIVLSIVSPLVRSFTVITSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLSREEDGALPDGATDVSSTSKSLGFSYLSAFFLVFPNFIFMLISS
What is the function of this protein?
Promotes cell fate progression in stomatal development.  In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids.  In stems, promotes the conversion of meristemoids into guard mother cells (GMC) (PubMed:11090210, PubMed:12040198, PubMed:18979118).  Positively regulates CAPRICE (CPC) expression in differentiating stomaless-forming cell files (PubMed:19513241).  Forms constitutive complexes with ERECTA and ERL1 involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146).  Modulates the activity of the ligand-receptor pairs EPF2-ERECTA and EPF1-ERL1 in stomatal development (PubMed:16002616, PubMed:22241782).  Functions in a combinatorial specific manner with the ERECTA-family (ERf) receptor kinases in the regulation of the immune response (PubMed:27446127).
What are the official names of this protein?
Protein TOO MANY MOUTHS, Receptor-like protein 17, AtRLP17.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
Protein: DAPB_CUPNH
Sequence: MNIAIAGASGRMGRMLIEQVLNTEGVSLAGALDVPGSPALGQDAGLLLGRQTGVAISSDVEAVLAGADCLIDFTRPEGTLAHVAAAKKLGVKMVIGTTGFDEAGKAALAEAARSIGIVFAANFSVGVNATFKLLEVAARLLSTGYDIEVIEAHHRFKVDAPSGTALKMGEVIADALGRDLKTCAVYAREGHTGERNPNSIGFATVRGGDIVGDHTVMFAGIGERIEISHKSSSRQSYADGAVRAARFLADKPNGLFDMQDVLGLK
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_BUCBP
Sequence: MKELFNILLINGPNLNLLGHREPKIYGNTTLSQLTHALTKEATTFNIHLHHIQSNSESTLINKIHNSKNNINYIIINAGAFSHTSIALRDALIGINIPFIEVHISNIYTRENFRSHSWLSDISSGVICGLGLDGYFWALRTAIKRIKKISTLQV
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: AIM9_LODEL
Sequence: MLSKSITRSLKQQVTKKSLSKAIAPSIARSLATSTPPSPSDGLKPSHVYTKLSHTDDPARSRFFQYSWGSWLKDDALKKKQRETIFSIEGLTAYLNSVDSLRVPETAKLLQPKEEQGTFVLQNNLTFDVLGAKSDVLLIKSISSIHEGKHHRIYKLTLSTGKDLVLRIPYKLESDTAIASKIKSEVATSDFLKLKLGLDVPKIIAYGPDRNNAIRSPFILQEFIEGELLMKKWNPLEPDSDKTDEDLKSVIAPIAEFQDKILEPVFTKFGSLYFYNDVTTELQQNGEPYEGENDEKLLKRWRVGPSVEKAFTKGKNKLSQDVIDQYNGPWDASNPEQVMTSVAEIEIENARNKLAIVDADAGDVTSKDLLQHQITTFEHLKQITPKLLNSKSPSIKNVEELFKPRLYVPDLDPLNVIQSTEGKNYFIDFEGSTIKPFILSSYPKFVEYQGAKIYDLKVDIPGFDEMDPVEKQQYEFMYYKTRNERLWEVELNKHRHDLIAVASPHIKVLKSPYLQALDLKHSKDYLYVEGAIVQLQSMWEAYVANELVKQDKDDKEFPIKYDEKYLDQYQLDLSDHQMETVSSPFSATGGWIPQDMFRTLKEQGILVEVGEGNYEIKTDKILENPPSETGEEPKA
What are the official names of this protein?
Altered inheritance of mitochondria protein 9, mitochondrial, Found in mitochondrial proteome protein 29.
What is the protein family that this protein belongs to?
Belongs to the AIM9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FBX2_MOUSE
Sequence: MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation.  Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol.  Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
What are the official names of this protein?
F-box only protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1200_SHESA
Sequence: MESLQNHFLIAMPSLDDTFFERTVIYLCEHDEKGAMGLVINKPLGIEVNSLLEQMDLPAEQVSTDLALGAQVLMGGPVSQDRGFVLHTSQPYWANSTELSSGLMLTTSRDVLTAIGSERSPEKFIVALGYAGWSKNQLEQELADNSWLTIPADQALLFDVKHEDRWQQASRALGFDAWQLSSQAGHA
What are the official names of this protein?
UPF0301 protein Shewana3_1200.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: METK_HALH5
Sequence: MADTRSRRLFTSESVTEGHPDKICDQISDSILDEILKEDPNARVACETSVTTGLVLVAGEITTSTYVDIPKVVRDTIRNIGYTRAKYGFDSETCAVLTSIDEQSPDIAQGVNQALEAREGQMTDAEIEAIGAGDQGLMFGYANNETPELMPLPISLSHKLARRLSEARKGEILPYLRPDGKTQVTVEYDENDQSVRIDTIVISTQHHPEVTLEQIESDLKQHVIRSVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSGAYAARYVAKNIVAAGLADKCEVQLAYAIGVAKPVSISIDTFGTGQVSEARLVELVREHFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVELPWEQTDKAEILRQQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: ENGB_SPHAL
Sequence: MSEIELEPGADPERAERARKLFSGPIAFLKSAPALQHLPVPSVPEIAFAGRSNVGKSSLLNALTNRNGLARTSVTPGRTQELNYFDVGEPPVFRLVDMPGYGFAKAPKDVVRKWRFLINDYLRGRQVLKRTLVLIDSRHGIKDVDRDVLEMLDTAAVSYRLVLTKADKIKASALADVHAATEAEARKHPAAHPEVIATSSEKGMGIAELRTAVLEAVEL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: UXT_BOVIN
Sequence: MATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH
What is the function of this protein?
Involved in gene transcription regulation.  Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription.  Together with URI1, associates with chromatin to the NKX3-1 promoter region.  Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm.  May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity.  Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling.  Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC.  Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.
What are the official names of this protein?
Protein UXT, Ubiquitously expressed transcript protein.
What is the protein family that this protein belongs to?
Belongs to the UXT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localizes to the nucleus. Localizes to spindle pole during mitosis.
Protein: GTFB_STRPN
Sequence: MIELYDSYSQESRDLHESLGATGLSQLGVVIDADGFLPDGLLSPFTYYLGYEDGKPLYFNQVPVSDFWEILGDNQSACIEDVTQERAVIHYADGMQARLVKQVDWKDLEGRVRQVDHYNRFGACFATTTYSADSEPIMTVYQDVNGQQVLLENHVTGDILLTLPGQSMRYFANKVEFITFFLQDLEIDTSQLIFNTLATPFLVSFHHPDKSGSDVLVWQEPLYDAIPGNMQLILESDNVRTKKIIIPNKATYERALELTDEKYHDQFVHLGYHYQFKRDNFLRRDALILTNSDQIEQVEAIAGALPDVTFRIAAVTEMSSKLLDMLCYPNVALYQNASPQKIQELYQLSDIYLDINHSNELLQAVRQAFEHNLLILGFNQTVHNRLYIAPDHLFESSEVAALVETIKLALSDVDQMRQALGKQGQHANYVDLVRYQETMQTVLGG
What is the function of this protein?
Required for the polymorphic O-glycosylation of the serine-rich repeat protein PsrP.  A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins encoded upstream in the same operon.  The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to PsrP, attaching the first sugar residue.  Stabilizes the glycosylation activity of GtfA (By similarity) (PubMed:24936067, PubMed:28246170).  Has no N-acetylglucosaminyl transferase activity on its own (PubMed:24936067).
What are the official names of this protein?
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase stabilizing protein GtfB, Glycosyltransferase stabilizing protein GtfB.
What is the protein family that this protein belongs to?
Belongs to the GtfB family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: APEB_MYCBP
Sequence: MAATAHGLCEFIDASPSPFHVCATVAGRLLGAGYRELREADRWPDKPGRYFTVRAGSLVAWNAEQSGHTQVPFRIVGAHTDSPNLRVKQHPDRLVAGWHVVALQPYGGVWLHSWLDRDLGISGRLSVRDGTGVSHRLVRIDDPILRVPQLAIHLAEDRKSLTLDPQRHINAVWGVGERVESFVGYVAQRAGVAAADVLAADLMTHDLTPSALIGASVNGTASLLSAPRLDNQASCYAGMEALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQSDLLSSVLERIVLAAGGTREDFLRRLTTSMLASADMAHATHPNYPDRHEPSHPIEVNAGPVLKVHPNLRYATDGRTAAAFALACQRAGVPMQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQLAMHSARELMGAHDVAAYSAALQAFLSAELSEA
What are the official names of this protein?
Probable M18 family aminopeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M18 family.
Protein: Y7544_AFIC5
Sequence: MADFLGMMKQAAQLQSKMKEMQEQLDQVEVEGSAGGSMVTVRMTAKMELKAVSIDPSLMKPEEREVLEDLLVAAQNDARRKAEEAMQERMKALTGGLSIPGLGLG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein OCAR_7544/OCA5_c05960.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ACDH2_MYCSJ
Sequence: MPEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQDDKPDLVFEATSAYVHRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVSSSSAGPGTRANIDEFTKTTSKGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDADRDAIAQSIRDVVAEVQTYVPGYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKESLSLAGGAQA
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.