PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_CHLAA
Sequence: MSDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAARAEEAIRAAGGMPQIFGTITVSDGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAVGGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLTIVSAFEAVGEYSAGRIDEHELLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLVEAIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQRVPVLCDLKPSGRYVATDLHRVGGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEPPANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIKQRRITGPARVFDAEEECLEAILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLVVGHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVLAKYARLVSSASLGAVTDRFSE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PUR9_LEPBP
Sequence: MIQIKRALVSVSDKTGITEICSFLTKHGVEILSTGGTYDALSKAGIAVKKVDEFTGFPEILHGRVKTLHPKIHGGLLGDTTNPDHVKQMESNGIVPITLVIVNLYPFVKTVMKPDVTLEDAIENIDIGGPSMLRSAAKNHKNVVVLTDPKDYESFQNEFTTNNGKISRETAFGYAAKVFSETASYDSAISSYFNKRLGIKYPDKITFAFNKKQKLRYGENPHQDAAFYEPLFLKSQFEALQGKELSFNNMLDFDAAFHVASLLPKNAVSIVKHLNPCGIAFGETVLESFELARKTDPISAFGGIIGIHGRVEKESAEEITKNFVEGVIAESFSNEALEIFAKKPNIRLIPIAKFDEALDELDLRSLHHGLLIQNRDYDLITKDKLKIVSKKQPTEDDLEGLMFAWNCVKFIKSNAIVYTDQNSTLGIGAGQMSRVDSVELGAMKAQKVGLSVVGSYVGSDAFFPFRDGIDAIAKVGAKAIIQPGGSIRDEEVIQAADEHGLIMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: UBIA_NEIMB
Sequence: MNPKSPLFLRLSDRLDVYLRLMRADKPIGTLLLLWPTYWALWLASDGIPDLAVLAAFTIGTFLMRSAGCVINDFADRDFDGAVERTKNRPFAQGRVKKKEALLLTAFLCLLAALCLIPLNHLTWLMSLPALFLALTYPFTKRFFPIPQLYLGLAFSFGIPMAFAAVAGNVPPQAWILFAANVLWTLAYDTVYAMADKEDDLKIGIKTSAVTFGRYDIAAVMLCHGGFTLLMAVLGAVIGAAWAYWTAIPIVLLLQYRQYAAIKSRVRQICFETFLANNRIGWVWFTAIFAHTFFAK
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPEE_RHOBA
Sequence: MIHRAPLHLLYLNVLVIATCGLIYELLAGTLASYLLGDSVTQFSLIIGVYLSALGFGAWLSQYVTTKLARVFIEVELALALLGGFSTPLLFLAFPMIEWFQWLLFGSVIVIGTLVGLELPLLMRILKEHLEFEELISRVLAFDYLGALFASLLFPIFLVPRLGLNRTAIVFGLLNALVGLWGTYLLRPLLAKKGLDGLRGRAFLVIGLLIAGFIKADSITSLAEENTLGGRIVYADTSPYQRIAVTRNEKGFQLYLNGHLQFNSVDEYRYHEALVHPVMSVCKDARRVLVLGGGDGLAVREILRYDHVESVTLVDLDPAMTRLATQFEPLAELNGRSLERDRVTVVHRDAFLWVGEGDEQFDAVVIDFPDPGNYSIGKLYSSRFYNLLRERMTEDAGLAIQCTSPLVAPKSYWCILRTMQASGFDVTPYHAPVPTFGIWGFALARIAEDPESDSDWRLPPELSAKVAGLRYLTPSTMAGLFDLPADQQPRDVPPNRLNDQILVRFYDEEWGQNQ
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPH_LISMC
Sequence: MEQMDAHQIISFIQNSKKATPVKVYLKGDLEKIDFPSDVKTFITGNAGTIFGEWAVVEPFLEANKANIEDYVIENDRRNSAIPLLDMKNINARIEPGAVIRDQVTIGDNAVIMMGASINIGSVIGDGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVVEPPSAQPVVVEDNVVVGANVVVLEGVRIGEGAVVAAGAIVTKDVAPGTVVAGIPARELKKLDAKTASKTEIMQELRQL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: A1AG_RAT
Sequence: MALHMVLVVLSLLPLLEAQNPEPANITLGIPITNETLKWLSDKWFYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQRENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQQAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP
What is the function of this protein?
Functions as transport protein in the blood stream.  Binds various ligands in the interior of its beta-barrel domain (By similarity).  Appears to function in modulating the activity of the immune system during the acute-phase reaction.
What are the official names of this protein?
Alpha-1-acid glycoprotein, Orosomucoid, OMD.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FB341_ARATH
Sequence: MDNQKGALFPDEVILQILARLPVKSLFRFKSVCKSWYRLPSDKYFTSLFNQLSVKEQLLVAEVSDSSSLICVDNLRGVSELSLDFVRDRVRIRVSSNGLLCCSSIPEKGVYYVCNPSTREYRKLPKSRERPVTRFYPDGEATLVGLACDLSKNKFNVVLAGYHRSFGQRPDGSFICLVFDSESNKWRKFVSVLEECSFTHMSKNQVVFVNGMLHWLMSGLCYILALDVEHDVWRKISLPDEIRIGNGGGNRVYLLESDGFLSVIQLSDVWMKIWKMSEYETETWSVVDSISLRCIKGLVPGIFPICQTGEYVFLATHKQVLVYQRRSKLWKEMFSVKGSSSLPLWFSAHAFRSTIVPCN
What are the official names of this protein?
F-box protein At5g49610.
Protein: TRMD_YERPG
Sequence: MWIGVISLFPEMFRAITDYGVTGRAVKNGLLSVQCWSPRDFTYDRHRTVDDRPYGGGPGMLMMVQPLREAIHAAKAAAGEGAKVIYLSPQGRKLDQQGVCELAMNQKMILVCGRYEGVDERVIKTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHHASAEEDSFVDGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLESLALTDEQMVLLAEFQREHKP
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEBO_ECO57
Sequence: MNEVVNSGVMNIASLVVSVVVLLIGLILWFFINRASSRTNEQIELLEALLDQQKRQNALLRRLCEANEPEKADKKTIESQKSVEDEDIIRLVAER
What are the official names of this protein?
Uncharacterized protein YebO.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OAZ_CANGA
Sequence: MEKKVSHVIDFLSNDEVQRQLGDPSISGISFSFDIRTLLKKHSGGNPQFFNYSMRDSFHEWCADIELGANTNELVTELLWDIIYLTEHQFLLPYYHGEHKKFQKKLVKRVGNHLNSLVNNSASKPTGSMTVNVRHVWRNVGDRYTLLYLPLYFKELIWCKANGSIFHVIIPHTKEHVIHEHKEWLLAILEMAGYWNLSHVRLYLPRDDLTNIQTLLKNLHWIGANLLPNENRNECNENDDITLSDETYIILECEC
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
What are the official names of this protein?
Ornithine decarboxylase antizyme.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: CAN1_PIG
Sequence: MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEAFPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILKALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGEVEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKSQRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSEEEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.  Proteolytically cleaves CTBP1.  Cleaves and activates caspase-7 (CASP7).
What are the official names of this protein?
Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain, muCANP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Protein: DOPO_CANLF
Sequence: MQVPSPSAREAASMYGTAVAVFLVLLVAVLQGLAPPESPLPYRIPLDPKGDLELSWDVSYTQKTIYFQLLVQELKAGVLFGMSDRGELENADLVVLWTDGDNAYFGDAWSDQRGQIHLDSQQDYQLLRAQRTPKGLCLLFKRPFGTCDPKDYFIEDGTVHLVYGVLEEPFGSLEAINTSGLQKGLQRVQLLKPKISIPALPEDRRTMDIQAHNVLIPSKTTYWCHLTKLPQDFPRHHIVMYEPIITKGNEALVHHIEIFQCTNQFQNITSFSGSCDSKEKPQELKVCRHVLAAWALGARAFYYPEEAGLAFGGSNSSRFLLLEIHYHNPTNIRGRYDNSGIRLHYTAKLRHFNAGIMELGLVYTPVMAIPPKESAFVLTGYCTAKCTQAALPPLGIRIFASQLHTHLTGTKVVTMLVRDGQEIEIVNRDDHYSPNFQEIRMLKKTVYVYPGDVLITSCTYNTEDKNEATVGGLGTQEEMCVNYIHYYPQTQLELCKSHIDPCFLQKYFHLVNRSNLGEYCTCPQASGTTCPQASGTTCPRASVPEQFASVPWNSFSRVVLKALYDFIPVTVHCNKSSAVRFPGKWDLQPLPEIISKLKEPTPRCPTSRDQSSSSLTVVNIGGGKV
What is the function of this protein?
Conversion of dopamine to noradrenaline.
What are the official names of this protein?
Dopamine beta-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Protein: TIG_BIFLS
Sequence: MKISVRNLEPTKVKLTVTVEPEELNPYLDAARKEIAKQVNVPGFRKGHVPGKIIDQRIGFAAVAGEAVNDAVPELYSKALDEKKIRPMAQPEFDVQDVPQSANDETKLKFTATVERRPDIELPEIDGLEIAISKPEVKDEDVDKRLETLRQRFGTLVGVDRPAAKGDFANIDLTAEIDGETVDSQEGVSYELGSNTMLDGLDEALDGLSAGEETTFEGTLEAGEHEGQKATVKVKVNSVKAEELPELDDEFASEASEFDTLDELKADIRKAAAQDAEGRQATEARDAFIAKLQEGLEIPVPKGVKANMVEEQLKGLTPDPEKATKEQKAQAEETVEKDLRDQMVLDALAEKLDVQVSQSDVFNFLASIAQQYGMDPNNFIQAIIKNGQLGSAVQEVARSKGLLAGMRAVKFTADGEVVDLSGFLGEAAEDEESESVEAASAAAAVADELSAKDDAKDAE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CCD40_MOUSE
Sequence: MMDAEKVSTDGEAISEGEVGSNGETPPETEVEFIGETAPDTDVEFIGETSPGTDVEPTGESIQETEVESIGEATPGMDVEPIKKTMTELNVESIGEETSETDVDSIRKALRGIDLESITVAYPPKKAKHRKVRPQAEVESTGRAAPEGELEVSDHEKVEALLDELDELSEIVSSPEVSYSDISPLEMGEDDTNVSATSTDTFQQGIYEPIEPIEPTEPPEPAEPPKPAETPEDSTVRAPAHPYQRDFPMGARHRFRLSIMGSLTPSDTDDLPLETDEPPQQESVQSTPRALEETRIQFLDQVQSLSPEALLDRATEGSDEAEEEGSQLIVLDPDHPLMIRFQEALKGYLNRQMDKLKLDVQELDVATKQTRSQRQELGVNLYGVQQHLARLQMQLEKSHDRHSLVACERRRKEEELQCARSVYNKTCQTANEERKKLAALQTEVESLALHLFYMQNIEQDVRDDIQVMKQVVRKTETEKMHAEVEKKKQDLFVDQLTERSHQLEENIALFEAQYLSQAEDTRVLKKAVTEAITEIDTIAVEKKRILQQWTTSLVGMKHRNEAYKTVMDALRECQHQVKSTDSEIEVCKKSIMQEEEKNEKLARLLNRAETEATLVQKMTAQCLSKQEALQTEFNTYQLALQDTEEMLNKGYVEHSAVLSELQATRQAFHQEQELRQKMDMSMVDKLQEQGTSSKMTKYFHQLLRKLQKENTNLVTHLSKIDGDIAQATLDITNTNCKIDMHKKTLAEMDKEVKRFNDLITNSESEIARRTILIERKQSLINFFNKQLEQMVSELGGEEAGPLELEIKRLSKLTEEYNTGVAEAQMTWLRLQQELVQVTHEREEQLVSVDQLKKEVHIMEQKKLRIESKIAHEKKEQKIVSRHMRDLDNDLSKLNMLLDKNRCSSEELEQNNIATETEFLRTLKDSERETIQMQEKLMELSEEKATLLNSFMEAEHQIMLWEKKIQLAKEMRSSVDSETGQTEIRAMKAEIHRMKVRHGQLLKQQEKMIRDMELAVARRETIVVQAEGQSKIDKKVITKTEFHYQQRELQKKVREMHKATDDCTNTISELEETQKFLSSSLQEKQQLLSEMQATTDVLEEEINQLTALKRQNLLEIVTLQTRGKHLQAAIEGKYVFLHRNSRSQLMERKRLSVRLSQLNKVLSSVQEDYPQYQEVLQSIQQKIATKLETPEPS
What is the function of this protein?
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella.  Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella.  Not required for outer dynein arm complexes assembly.  Required for axonemal recruitment of CCDC39.
What are the official names of this protein?
Coiled-coil domain-containing protein 40, Protein links.
What is the protein family that this protein belongs to?
Belongs to the CCDC40 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Note=Localizes to cytoplasm and motile cilium.
Protein: NDHI_DAHCO
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ZYX_XENTR
Sequence: MDPAAPAARMTSSFTINISTPSFYNPPKKFAPVVPPKPKVNPFRAAEEPVPQENSAGPGLRRAFVGKVGQIPSMAPPGGDPEDFVLPPPPPNEEPMSPPGSSFPPPPPSFGDDGPGSPLGLFPPPPPPEFSEPFPPPIEESFPSPPPLEEAAGLSDTQDPPASVPPPPPPLPSPPEPAPPVLCEAPKPAPVLPKPPPPSAFPKPEPPQSVAPKAQSSIFIPKPSPPSAVAPKPVAPPPVAAKPSGPGPFVGPSAAPPTHTPAPPAPAHTFSPKPVAGPTFAPKSASHTFMAKPSAPVFSPKAATEPPTEAPQERFPASQSSPKLTPAAKHEAPPPAAKHEAPPPASATRAPGFSFAQQRDKPRVLEKPRANVRDLVPEPPVETRGERTLGPQAEGGRSFGAQPIGGKDTKPLPEGLRNQTPDGTHRVGGQPGTHRPTPHQDQTSGSQGLNMKEVEELEMLTQQLMQEMDKPTPAAEAHTMELCGFCGRGLSRTETVVRAGEHLYHVTCFTCSKCEQQLQGQQYYESAGKPLCEECYQDTLECCAVCEKKITERLLRAIGQAYHPSCFTCAVCKCSLQGEPFIVDDNKLPHCVSDYHRRYAPRCTVCGDPIAPEPGRDETVRVVALEKNFHMMCYKCEDCGCPLSIEADDGGCFPLDGHVLCKKCHTVRARAALG
What is the function of this protein?
Adhesion plaque protein.  May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.  Suppresses the transcription-repressing activity of hesx1/anf1 (By similarity).
What are the official names of this protein?
Zyxin.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of hesx1 (By similarity).
Protein: PURT_SHEB8
Sequence: MIGTPYTEGARRAMLLGCGELGKEVAIELQRLGVEVIGVDRYANAPAMQVAHRSHVINMLDANALRAVIELEKPHLVIPEIEAIATQTLVDMEAEGVNIIPTARATKLTMDREGIRRLAAETLGLPTSPYFFCDTETEFNQAISEIGVPCVVKPVMSSSGKGQSVIRDIALSHKAWQYAQEGGRAGGGRVIVEGFIPFDYEITLLTISAVNGIHFCAPIGHRQEDGDYRESWQPQAMSDEVLAKSQAIASKVVEALGGYGLFGVELFVKGHEVYFSEVSPRPHDTGLVTLISQDLSEFALHVRAIQGLPIPNIHQHGPSASAVILAEGTSSNIRYQGIAAALEAVNTQLRLFAKPDIDGRRRLGVALARDIDIDSAVSKALDSASKVKVIF
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: FOLD_CHLTR
Sequence: MLLKGAPAADHILATIKENIRACSKAPGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDATLSDILALIHQLNNDENIHGILVQLPLPKHLDAQAILSTITPDKDVDGLHPVNVGKLLLGETDGFIPCTPAGIVELCKYYEIPLHGKHVVILGRSNIVGKPLAALLMQRHADTNASVTLLHSQSEHLTEITRTADILISAIGVPLFVNKEMIAEKTVIMDVGTSRIPAANPKGYILVGDVDFNNVVPVCRAITPVPGGVGPMTVAMLMRNTWESFLRHTS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL15_FRATT
Sequence: MKLNTLAPAAGSKSAPKRLGRGIGSGLGKTSGKGHKGQKARSGGYHKVGFEGGQMPLQRRLPKFGFTSASKGYVAEIRLHELNNVVADEVTLDTLKDFGLIRKDIKTVKVIASGEIQKAVSLKGIACTKGAKEAIEKAGGKVE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: TUBE_BPMU
Sequence: MAGNQRQGVAFIRVNGMELESMEGASFTPSGITREEVTGSRVYGWKGKPRAAKVECKIPGGGPIGLDEIIDWENITVEFQADTGETWMLANAWQADEPKNDGGEISLVLMAKQSKRIA
What is the function of this protein?
Polymerizes to make up the central tail tube that is surrounded by the tail sheath protein (TSP).  Tail tube protein polymerization takes place around the tape measure protein (TMP) and is probably directed by chaperone proteins.  Upon binding to host cell, the tail sheath contracts and the tail tube penetrates the host envelope.  The tail tube is involved in viral genome delivery during ejection.
What are the official names of this protein?
Tail tube protein, TTP, Gene product 40, gp40, Gene product M, gpM.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Tail.
Protein: RS13_YERP3
Sequence: MARIAGINIPDQKHTVIALTAIFGIGKTRSQAICVAAGIAEHVKISELSEEQIEKLRDEVAKYVVEGDLRREVTLSIKRLMDLGTYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CYC_MIRLE
Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFSYTDANKNKGITWGEETLMEYLENPKKYIPGTKMIFAGIKKTGERADLIAYLKIATKE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: RISB_PYRFU
Sequence: MKVRTFEGDYRGEGLRIAVVVSRFNDLLTEELLKGALDCFKRHGVEEVHIFRVPGSFEIPITVKKIAKRGYDAILALGVLIKGETRHFELVASQVSRGIAQVSLEEGIPVIFGIVPAEDEIQAISRSGIKSNRGFEYALTTIEMANLFRKLGENNER
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: OTX1_MOUSE
Sequence: MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGNGTKTRPVKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSASANPAAAAAAGLGGNPVAAASSLSTPTASSIWSPASISPGSAPTSVSVPEPLAAPSNASCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPAPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPAAAAASSAWKLNFNSPDCLDYKDQASWRFQVL
What is the function of this protein?
Probably plays a role in the development of the brain and the sense organs.  Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
What are the official names of this protein?
Homeobox protein OTX1, Orthodenticle homolog 1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDUC1_HUMAN
Sequence: MAPSALLRPLSRLLAPARLPSGPSVRSKFYVREPPNAKPDWLKVGFTLGTTVFLWIYLIKQHNEDILEYKRRNGLE
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial, Complex I-KFYI, CI-KFYI, NADH-ubiquinone oxidoreductase KFYI subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFC1 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: RL16_MYCS2
Sequence: MLIPRKVKHRKQHHPEQRGIASGGTSVSFGDYGIQALEHAYITNRQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLFELSYPDEKTARDALTRAIHKLPIKARIVTREEQF
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RSMI_HALH5
Sequence: MKTQQSYQQRDDKGTLYLVATPIGNLEDVTFRAIRTLKEADQIAAEDTRQTKKLLNHFDIATKLVSYHEHNKETMGKRLIDDLIEGRTIALVSDAGMPAISDPGYELVVSAIKEGIAVIPIPGANAAVTALIASGLPTESFQFIGFLPRQKKQRRQALEETKPTKATLIFYESPHRLKDTLDDMLLILGNRHVSICRELTKTYEEFLRGTLEEAVHWAREATIKGEFCLIVEGNGEKVEPEEVWWESLSPVQHVEHYIALGFRSKEAIKQVATDRGVPKRDIYNIYHQE
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.