PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_STRAW
Sequence: MANRQQPTSMPIHKYRPYEQVDIADRTWPDNRVTVAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVKMGYKEIEVGFPASGQTDFDFVRSIIEDETAIPDDVTISVLTQAREDLIERTVESLVGAKRATVHLYNATAPVFRRVVFRGSKDQIKQIAVDGTRLVVEYAEKLLDERTTFGYQYSPEIFTDTELDFALEVCEAVMDVWQPGPDREIILNLPATVERSTPSTHADRFEWMSRNLSRREYVCLSVHPHNDRGTAVAAAELALMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSNIDEVRRTAEYCNQMEVHARHPYVGDLVYTSFSGSHQDAIKKGFDAMEADAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRRMQIEFSKIIQTKTDAEGGEVTPKDIWAVFQDEYLPNPRNPWGRIQVKTGQTTTDKDGVDTLTVEASVDGVDTVLTGSGNGPISAFFDALQSVGIDVRLLDYTEHTMSEGASAQAASYIECAIDGQVLWGIGIDANTTRASLKAVVSAVNRAAR
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: ISCA2_HUMAN
Sequence: MAAAWGSSLTAATQRAVTPWPRGRLLTASLGPQARREASSSSPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKL
What is the function of this protein?
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.  May be involved in the binding of an intermediate of Fe/S cluster assembly.
What are the official names of this protein?
Iron-sulfur cluster assembly 2 homolog, mitochondrial, HESB-like domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FLAE_METJA
Sequence: MGEVFKMDGLASTILEVHKPAKLEDIPDEDPIAIILALKWLEYLCERAGVENVSDILDFYYMLGWLGDKALAKLLKFLKGIKVDEENVVEGSGKLNITDHIISLLFIERLNGKKISAELLDKIEWELRKIKKGAEQFYGI
What are the official names of this protein?
Putative flagella-related protein E.
What is the protein family that this protein belongs to?
To M.voltae FlaE, also to FlaD.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: MUTS_PARP8
Sequence: MGTQTAAASDIAQHTPMMQQYLRIKGEHPGTLVFYRMGDFYELFFDDAEKAARLLDLTLTQRGASGGNPIKMAGVPHHAVEQYLAKLVKLGESVAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKSDTYLLAACAGHNRRGVVTTVGLAWLNLASGALRLAEVAPDQVAAALERIRPAEILVADAPSSSDANAWSVPTGFGATTRVPLWHFDVASGTQRLCDQLEVAGLDGFGAHSLTCACGAAGALLLYAAATQGQQLRHVRSLKVEYESEYIGLDPSTRRNLELTETLRGTDSPTLCSLLDTCCTTMGSRLLRHWLHHPPRDASFAQARQQAIGALLDSPPQASLDALCGALRQISDIERITGRLALLSARPRDLSSLRDTFIALPELRAQLVPLTGAADSLARIHASLEPPADCVDLLTRAVAQEPAAMIRDGGVIARGYDVDLDELRDISENCGQFLIDLETRERARTGIGNLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALAREKALYDALLQSLLPFIADCQRVASALAELDLLAAFAERARALDWVAPNFSATGGIDIEQGRHPVVEAQVEQFIANDCMLNPERKLLLITGPNMGGKSTFMRQTALIALMAYVGSYVPARRASFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPQSLVLMDEIGRGTSTFDGLALAWAIARHLLAHNGCHTLFATHYFELTQLPAEFPHAANVHLSAVEHGHGIVFLHAVNEGPANQSYGLQVAQLAGVPNAVIRAARKHLAYLEQQSAGAPAPQLDLFSAPVAMLEDADDESIAPALDAATRTLVERLRDIDPNDLRPRDALDLLYELHELAKSPDAPR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ALG3_ASPFU
Sequence: MQLHRINTMDLKHSLRDLCMNPRHTSWAAPLLILGDAVLCALIIWRVPYTEIDWTTYMQQISLYISGERDYTLIKGSTGPLVYPAAHVYIYNILYHLTDEGRDIFLGQILFAILYLATLTVAMTCYRQAGAPPYLLVPLVLSKRLHSVFMLRLFNDGIAAFAMWVSIFLFMNKKLAAGVIVWSTGVAIKMTLLLLAPAIAMVLVLSLSFGPSIRLGFLAVLIQVLFGIPFLRNNPAGYVSRAFELTRQFMFKWTVNWRFVGEELFLSRKFSLALLALHLLLLGLFVATVWLEPSGSNLPSFLQRLIQRRYRTASLSKSFVMTAMLSSLAIGLLCARSLHYQFFAYLACATPFLLWQAGFHPILVYVVWAAQEWAWNAYPSTNASSLVVVLSLAAQVFGVLGNSFSRKHLDQSSQKEHMQ
What is the function of this protein?
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, Asparagine-linked glycosylation protein 6, Dol-P-Man-dependent alpha(1-3)-mannosyltransferase, Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TF2B_METM5
Sequence: MKVESVVKEETKKPERKIKLAIAKPEDYSNKNVILEKEEELICPVCGSKSIIKDYERAEIVCEMCGCVLQQNLFDVGPEWRAFDHEQRVKRSRVGAPMTYTIHDKGLSTVIDWRNKDSYGKDISADKRAQLYRLRKWQRRIRVSDASERNLAFALSELDRIASKLGLPRNVRENAAVLYRGAVEKGLIRGRSIEGVAAAALYAACRRCKVPRTLDEIAEVSRVDRKEIGRTYRFISRELNIRLAPTNPVDYVPRFASELKLPGEVESKAISILQKAGEKGLTSSRGPTGVAAAAIYIASVLQGTRRTQREVADVAGVTEVTIRNRYKELTEHLDIDVTL
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: SPEE_NITEU
Sequence: MSTSERPPSPSSMAEDFAVEPLSPDFGFYLRTTELLAERHSPVQHIEIVQTPLFGRAMRIDGCFMTSEQDEFFYHEPMVHLPAITHGDPRQALVVGGGDGGTAYNLLRYPNMERVVLAELDRDVIDMARTWLPKVHRGAFEDPRLELHLGDGRAFTGNCKNQFDQIVLDLTDPFGPAISLYTRDFYRACRRALKPGGVLSLHIQSPIYRSPIMARLLASLRDVFGVVRPYLQYVPLYGTLWAMAMASDSADPLSLSATEIDARLTQNGLIDLKLYSGGTHHALLNLPPFVQTLLSEPAYPIDDGNSLDDINLDPREAGKLKLIQT
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBK63_ARATH
Sequence: MTIPELPKDLIEEILCYVPATYLKRLRSTCKGWNRLFKDDRRFAKKHYDKAAKQFLPLMSTNEELCAMSVNLHGTIPSLEVKDKPWLFVSDSKHCDIEISRIFHSGGLLLCFSRDGEISIIVWNPLTSETRLIRTRNRRDKGRNFVLGYYQEDKKTYYKILSFYLDSKDFEIFEFNSDSWRFIDDICPGLSLLYSDQCVSLKGNTYMFAIDDLSVSLLKYDFSTETSVPVPLPYKSRSFEAISLSVVREEKLSVLLQRDKSSKTEIWVTNVIDETTTKVMVVSWSKVLSLDLSPDLKIRYGESFLLDEEKKVIMIFNNRMEEENKSEDKLYIIGDDDNKATQVYTIHGYGPAVFNYFPSLVQIEQSSRQEEKS
What are the official names of this protein?
Putative F-box/kelch-repeat protein At3g19410.
Protein: PDXS_FRATU
Sequence: MSDINIKIGLAEMLKGGVIMDVVNAEQAEIAQQAGAVAVMALERVPADIRKDGGIARMSDPKLIKEIMSVVSIPVMAKARIGHFVEAQILESLGVDFIDESEVLTPADELNHIDKDSFKVPFVCGCTNLGEALRRIGEGAALIRTKGEAGTGNIVEAVRQLRQVNKDINYIKNADKSELMAIAKNLQAPYDLVTYVHKNGKLPVPNFSAGGVATPADAALMMQLGAESVFVGSGIFKSA
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: PESC_CAEEL
Sequence: MKDRFKQKYTAGAAVAYMSRKQALKKLQLTLKDFRRLCIIKGIYPHEPAHKKQANKGSTANKVFYYRKDINFLAHEPIINKFRDYKVFLRKLNHLKAKKEEDKLKKLYENKPVYSLDTIVKERFPTFGSALRDMDDALSLCFTFAMLPHTRVLKEGMIDSCRKLTAEFMHYVIESQSLRNTFISIKGIYYQAEVHGEKITWVVPHERGLPHVTDVDFTVLVTFVEFYIAMLGFVNFKLYQDIGLFYPPQIGQVVKTDEMETEEYKEKVYSLAKPLAKRKDVEQAEDDEPLDLLGEDSDALAQKVREAKSIKTMFKGCVFYLNRECPKEALTFIIRNGGGIVGWEGGPTDLKADSKNISHHVVDRPMDKLEVNRLYVQPQWVFDCLNARRKLPTERYMPGVALPPHFSPFTSEKAGDYIPFERLEELRSMGKDVSDLEAAIPKTMDELPMRRKEVKPEKPKGIHIAVGQMHKKSKEKFHETVEKGQELKMRELMISKKHQRVYHSMKTTFKRNRNDALKLKKKAKLAKATEA
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Pescadillo homolog, Lipid depleted protein 7.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RNH_BRUA4
Sequence: MKRIEAYTDGACSGNPGPGGWGAILRWNDNVKELKGGEADTTNNRMELMAAISALSALKEPCEVDLYTDSVYVRDGISGWIEGWKRNGWKTAAKKPVKNAELWQALDEARKPHKVNWHWVKGHAGHPENERADELAREGMEPFKYGGRKSLKVQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRR7_HUMAN
Sequence: MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
What is the function of this protein?
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity).  Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189).  Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222).  Might promote apoptosis in T cells (PubMed:21460222).
What are the official names of this protein?
Proline-rich protein 7, Synaptic proline-rich membrane protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Postsynaptic cell membrane; Single-pass type III membrane protein. Postsynaptic density membrane. Cytoplasm, perinuclear region. Synapse. Cell projection, dendrite. Nucleus. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity).
Protein: IF2_POLNS
Sequence: MATTVKVLAKELKRTAPDLLEQLKAAGIEKGSEDDSITEKDKTVLLEHLQKAHGSTDTGARKKITLIKRESSEIRQADSAGRTRTVQVEVRKKRVLVKAGDKAPEEVAAQPVKQVAPAAPAKPVISEEELEKRAAEATRQAELLARQEAEMKAAEEARQKEVTVPVVKEVAPVDKAPVAPAVAEKKLAADKAAKDLAASKEKELADIRARRAAAEAEALAIRDMMSAPARVLKAPSEVAAEEAKKGTLHKPAKAEGAEDKKKAATKVGGKTIKSSETSSTWQEEGTRKSGGLKTRGDTSGGVGGWRSGGGRKKQRQIAEANVDTNFQVPIEPVIRDVHVPETITVAELAHAMAVKSAEVIKLLMGMGQMVTINQVLDQDTAMIIVEEMGHKAHAAKLDDPDLDLGTEGHDAELLPRPPVVTVMGHVDHGKTSLLDKIRTAKVAIGEVGGITQHIGAYHVETPRGMITFLDTPGHEAFTAMRARGAKATDIVILVVAADDGVMPQTKEAIHHAIAGGVPLVVAINKIDKPEANSERVKAELVAEQVVLEEYGGDVPFIPVSAKTGEGIDALLENVLLQAEILELKAPKEAPAQGLVIEARLDKGKGPVATVLVQSGTLKRGDMLLAGSSFGRVRAMMDENGKPCNEAGPSIPVEIQGLSEVPAAGEAVQVMPDERKAREIALFRQGKFRDVKLAKQQAVKLENMMETIGEGAIEAKLLPLIIKADVQGSQEALSQLLMKLSIPEVKVQIVHAAVGGITETDVNLAVVSKAVIIGFNSRADAAARKLAENNGVDIRYHNIIYDAVDEVKLALSGMLIPGKKEEITGLVEIRQVFLVSKVGAIAGCLVVDGIVKRTSSVRLLRDNVVVWTGELDSLKRFKDDAKEVRAGVECGLSLKGYNDIKEGDQLEVFEVTEVARSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1248_HAEIN
Sequence: MKKYKTGLVLLVIALALLVYFSPWFFLHIASWQKEFNQLISENLHQIQNNSIKAGTTLIFASFVYGVLHALGPGHGKFIIASYLSTHESQLKQSTILSLLSSLMQGIVAITATTLLVVVLNLSSRYFKLSQLWLERTALLLLVFLGCYWIWQGLRAYRKKAKLAIKSLNPLPLHEKSAVKNNRTFQPNTCSCGHQHLPSPTQTAQATNLKSQFLVILTIGMRPCSGAIFVLFLAYMLDLYSWGILAVLAMSFGTGLMLSAFAGIVRYARNTAIHLGHWYSSKNTKGKSESIVKLIAGGIMLFFALSLLYGTTISTGGSKILF
What is the function of this protein?
Efflux system for nickel and cobalt.
What are the official names of this protein?
Putative nickel/cobalt efflux system HI_1248.
What is the protein family that this protein belongs to?
Belongs to the NiCoT transporter (TC 2.A.52) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURA_THIDA
Sequence: MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHMGVRVTLDDKNHVTLSGDSIPHKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIGSRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMDMVTVTGTENLMMAAALAEGTTVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFLVAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHPAFPTDMQAQFMAMNTIAVGAASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARLDGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYERIEEKLTQLGGRIKRVH
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTX1A_NEOAP
Sequence: FLGGLMKIGAKLLPSVIGLFKKKQ
What is the function of this protein?
Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S. cerevisiae.  Has insecticidal and hemolytic activities.
What are the official names of this protein?
U1-poneritoxin-Na1a, U1-PONTX-Na1a, Poneratoxin, Ponericin Pa II1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family. Ponericin-W subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HTF2_PERAM
Sequence: QLTFTPNW
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor 2, Hypertrehalosaemic factor II, Neuropeptide M-II, PeA-CAH-II, Periplanetin CC-2.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROA_LISMC
Sequence: MKLITNKQGLVGAITVPGDKSMSHRSIMFGAIAEGKTVIRHFLRADDCLGTIKAFKALGVKIEETEEEIIVHGTGFDGLKQADGPLDIGNSGTTIRLMMGILAGRDFDTVILGDESIAKRPMNRVMLPLQQMGAKMHGKDGSEFAPITINGKQSLKRMEYHMPVASAQVKSAIIFAALQAEGETIIHEKEKTRDHTEHMIRQFGGEIEMDGLTIRVKGGQTFTGQEMTVPGDVSSAAFFIVAGLITPGSEIELTHVGLNPTRTGIFDVVEQMGGSLVVKDSSRSTGKLAGTVVVKTSDLKGTEIGGDIIPRLIDEIPVIALLATQAEGTTIIKDAAELKVKETNRIDAVATELNKMGADITPTEDGLIIRGKTPLHAANVTSYGDHRIGMMLQIAALLVEEGDVELERPEAVSVSYPTFFEDIRSLLK
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_PSEAB
Sequence: MPELPEVETTRRGIAPYLEGQRVERVIVRERRLRWPIPEDLDVRLSGQRIVSVERRAKYLLLGAEAGTLISHLGMSGSLRLVESGTPASRHEHVDIELASGMALRYTDPRRFGAMLWSLAPLEHELLRNLGPEPLTDAFAGQRLFELSRGRSMAVKPFIMDNAVVVGVGNIYASEALFAAGIDPRKPAGSISKARYLRLAEEIKRILAIAIERGGTTLRDFVGGDGQPGYFQQELFVYGRGGEFCKVCGSTLREIRLGQRASVYCPRCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: FTHS_LISIN
Sequence: MSNKVKSDIEIASVAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEQGKLVLVTAINPTPAGEGKSTVTVGLGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQVIPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLGIDGRRIVWKRVVDLNDRALRKVVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVGEMGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALKLGEYVVTEAGFGADLGAEKFLDIKVPALGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKGFTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEQLCEEHGIPFSLTEVWEKGGDGGLELADKVIAAVESGEEDYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKKYGWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLPKKPAALNMDVDENGNAQGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: UPS1_SCHPO
Sequence: MTAICTDKTELNASWNTVSSAWLTRYPNPYSLHVVSADVLERYVDDEGRLYTERLLVKQGRLPRWASDLLNVNKSYILERSVIDPSKQELKSETFNLDHVKILRVIEYSRFIQSSENCSKTIVDTIAKFVSPLRFGLGRRVQKYSLKRFQEQLSSSRRGLLYVIQQKFQPS
What is the function of this protein?
Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1.
What are the official names of this protein?
Protein ups1 homolog.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space.
Protein: TTCA_CUPMC
Sequence: MSHSANFYRLETRLQSLTGKAIGDFGMIEDGDTVLVCMSGGKDSYTMLSVLTALQKRAPIQFKLIAMNLDQKQPGFPEHVLPAYLKSLGVEYVIVEADTYSIVKEKVPEGKTTCSLCSRLRRGVIYRTAKELGANKIALGHHRDDIVNTFFLNMFFGGKMKAMPPKLATDDGQHIVIRPLAYCAEKDIASYARAMAFPIIPCNLCGSQENLQRKKVSEMLQAWERENPGRIDNIFAALRNVVPSHLADTDLFPFTGLATGLAKIDEASLFGETTFTQQALTFTGNVEANRMEFVRFDKIQKVQEAPERASEPSA
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIC_SALSE
Sequence: MAQVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEEIDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATVGDLKSSFKNVTGYDTYAAGADKYRVDINSGAVVTDDAAPDKVYVNAANGQLTTDDAENNTAVNLFKTTKSTAGTDEAKAIASAIKGGKEGDTFDYKGVSFTIDTKAGNDGNGTVSTTINGEKVTLTVADITAGAANVNDATLQSSKNVYTSVVNGQFTFDDKTKNESAKLSDLEANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAAAAKKSTANPLASIDSALSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNSARSRIEDADYATEVSNMSKAQILQQAGTSVLAQANQVPQNVLSLLR
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
What are the official names of this protein?
Flagellin, Phase 1-C flagellin.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: RSMH_JANMA
Sequence: MNADAVQQYQHRTVLLDEAVDALALGGERANGVYVDGTFGRGGHSRKILQQLGSGARLLAFDKDTQAIANAATIDDQRFEIAHDSFATLSEALAVRGIKQVDGVLLDLGISSPQVDDATRGFSFRADGPLDMRMDTTRGMSAAEWLATETEQKIEKVIREYGEERFAFQIAKAIVARRAVEPISSTRQLAEIVARTVKTREKGKDPATRTFQAIRIFINQELEELEVVLNEAYRYLAPHGRLVVISFHSLEDRIVKQFMAGKANVPQPDRRLPIRAIDLPQPEMKLLSRVKPSAAEISENPRARSAVMRVAERLSPAARVVQ
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_PSEP1
Sequence: MKKIEKTLDEWRSMLDPEQYQVCRLKGTERPFSGKYNSERRDGIYHCICCGLALFDAQTKFDAGCGWPSFYAPIEDSAMIEIRDTSHGMIRTEVTCARCDAHLGHVFPDGPPPTGLRYCINSVCIDLRPRD
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: NREC_STAA1
Sequence: MKIVIADDHAVVRTGFSMILNYQNDMEVVATAADGVEAYQKVMEYKPDVLLMDLSMPPGESGLIATSKIADSFPETKILILTMFDDEEYLFHVLRNGAKGYILKNAPDEQLLLAIRTVYKGETYVDMKLTTSLVNEFVSNSNQDTANTTDPFKILSKRELEILPLIAKGYGNKEIAEKLFVSVKTVEAHKTHIMTKLGLKSKPELVEYALKKKLLEF
What is the function of this protein?
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen.  Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).
What are the official names of this protein?
Oxygen regulatory protein NreC, Nitrogen regulation protein C.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_AGRRK
Sequence: MSDETHHSPDGKMSIRKLSYLAVGSVGVVYGDIGTSPLYAFREALKPVAADGLTRGEVISLVSLMFWALTIIVTMKYVLFLLRADNDGEGGTLSLLALLMKTANGHTAVLMLLGLLGAALFLGDAMITPALSVLSAVEGLKLVTPTLSDYIVPISVAILALLFAIQSHGTGAVARFFGPITAIWFIVMGLAGIMHIADDYGILAALNPWYAVNFLMNEGFLGVVVLGAVFLTVTGAEALYADLGHFGRRPIQWAWFVLVFPSLTLNYLGQGALVLREPLAMSDPFFLMYPHWALLPVVILATMATIIASQAVITGAFSLTRQAIHLGFLPRMEILITSETNTGQIFLPSVNAILFFGVIFLVLSFKTSDALATAYGISVTGAMVVTSIMAFEFVRVRWNWTLPMAIAVLTPLLLLEFVFLGANLLKIHDGGYVPVLIATAFTVIMWTWRRGSAILMEKTRHTDIPLSSFVSSIERKSDHSPAHVPGTAIFLTSDPESAPAALLHNLKHNHVLHDKNVILTIRTTNKPRVPQEDRYSVEKVSDRFSRVELRFGFMESQNVSQALATLRKTGLKFDIMSTSFYLGRRKLVPDAKSGMPHWQDRLYIALANAATDPSDYFRLPANRVVELGSHVII
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAX_BACAH
Sequence: MIFVLDVGNTNAVLGVFEEGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSRAAKLPRIEITKPSSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNANLQHEKGE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.