PharMolix/UniProtQA huggingface dataset:
Protein: PTGDS_CANLF
Sequence: MGALCTLWLGLVLLGVLGALQTSAQAQVSLQPNFQQDKFLGRWFTSGLASNSSWFREKKNVLSMCMSVVAPTADGGLNLTSTFLRKDQCETRTLLLRPAGTPGCYSYTSPHWGSTHDVWVVATNYEEYALLYTAGSKGLGQDFHMATLYSRTQTPKAEIKEKFSTFAKTQGFTEDAIVFLPQTDKCMEENK
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: HRD1_CAEBR
Sequence: MRVSAGLMIGGSCVATAATVLNAFVINKQFYPSIVYLSKSNASMAVLYFQGIVLVYLMFQLLKSILFGDLRAAEAEHLSERTWHAVLETCLAFTVFRDDFSAMFVMQFIGLLFIKCFHWLADDRVDMMERSPVITLRFHLRMMTVLAALGFADSYFVSSAYFSTITKGASSQIVFGFEYAILLALVLHVTIKYLLHMHDLRNPQSWDNKAVYLLYAELLINLIRCVLYGFFAVIMLRVHTFPLFSVRPFYQSVRALHKAFLDVILSRRAINAMNSQFPVVSNDELSAMDATCIICREEMTVESSPKRLPCSHVFHAHCLRSWFQRQQTCPTCRTDIWQGRNGAAGGANAGGAAENNAAGAPPAAGIPPFLPFLGHQFGFPQAAAGAQVGGAQAGGHPGPFPHQIFYAPAPANRPEFMNLAPPPMPMAGPPGMFPMMPPPPIPQPNAAPGESSNAEPPGRPNFDRFSVEELHRMEGDMRDAILARIQAMENIMVILESAQVQMVQLAAITPLRRPVPTAEASEEETATASSVPTSVPSEEPSPAPSTPETASAPRSMFRGNLFNDTQSTSTPSTSAGPQPSLTPSTSSVPSTSSVRTPEADEVRQRRLAHLNARFPPPNPEHE
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation.  Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.  Also promotes the degradation of normal but naturally short-lived proteins.  Protects cells from ER stress-induced apoptosis.  Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase hrd-1, RING-type E3 ubiquitin transferase hrd-1, Suppressor/enhancer of lin-12.
What is the protein family that this protein belongs to?
Belongs to the HRD1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AMPP3_PARBD
Sequence: MAISVDQTPAGKYPAKVHAKRVAARIQELGHGDSGIIYLEGQKTHMIEDSDGEMPFRQRRNFFYLSGCPLPDSYLTYDIKADKLTIFIPPIDPASVIWSGLPLSVEEALEIYDVDAVLSTAEVNASLAHYCSAQGGKKVFAIADQVSPHITFLPFQEIDFDVLKRAVEESRVVKDSYEIALLRRANEISSKAHVAVFKAATSARNERELEAIFVGACMSSGCREQSYHPIFASGTNAATLHYQKNDEDLVDSVTGQRRLNMLIDAGAEYRNYCADITRVVPLSGKFSPESREIYDIVLEMQNSSLAMIKAGVMWEDVHSTSHRVAIRGLLKLGILRSTEEELFEKGISVAFFPHGLGHYLGMDTHDTGGNPNYADKDPKFKYLRLRGPLASGGVVTVEPGIYFCRFIIDPYLSSPDLGKYINADVLERYWSVGGVRIEDNVVVTDSGYDNLTTAPKLPEEIERLATEK
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase PEPP, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: CYNS_PROM1
Sequence: MSFPESTQLLLKAKKEKGLTFADIGILLGLDEVWVASLFYGQSTASDEEADKLLTTLGLGTEHKEILTTPPVKGSLDPVIPTDPLIYRFYEIMQVYGMPMKDVIQEKFGDGIMSAIDFTINVDKVEDPKGDRVKVSMCGKFLPYKKW
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: PROB_ECO8A
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH601_SYNPW
Sequence: MAKLLKFSDESRAALERGMNALADAVRVTIGPRGRNVVLEKSFGAPDIVNDGDTIAKEIDLEDPFENIGAKLIQQVASKTKDKAGDGTTTATVLAQAMVEEGLRNTAAGASPIELRRGMEKAVALIVKGLGERSQSVSGDAIRQVATVSAGGDDEVGRMVAEAMDKVTVDGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDGDRQICEFENALLLLTDRKISAVADLVPVLETVQKTGSPLVILAEEVDGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALADIAILTGGTVISEDRAMTLDKVTLEDLGRARRITISKEETTIVASEDSRDAVAERVASIRRELENSDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGSTLIQLAGSLDGLANQLHGDQRTGVEIVHRALSAPLRQIAINAGANGDVVVEQVQRSGQGFNALTGGYENLLEAGILDAAKVVRLGLQDAVSIASLLITTEVVVADKPEPPAAPAPGGDPMGGMGGMGGMGGMGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCPR_YARLI
Sequence: MRSFRAVRNFSTTAKRLSQAPKASTPNASSGNGFVLAFVAAAAGAGAYYYYANSPAAKVETFNATKADYQKVYDAIADKLIEDDDYDDGSYGPVLLRLAWHSSGTYNKSDNKFGSSGGTMRFKPEASHAANNGLVNARNFLKPIHEKFPWISTGDLYTLGGVTAVQELGGPIIPWKRGRVDEPESASPPDGSLPDASQGATHVRNVFNRQGFNDQEMVALIGAHALGRCHKQNSGFEGPWTFSPTMFTNDFYKLLLDDKWQWKKWDGNPQYEDVKTKSLMMLPTDMALATDKNFKKWATAYAKDQDLFFKDFSAAFSKMLNNGVDFPQGTEIWEFKPKNA
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Cytochrome c peroxidase, mitochondrial, CCP.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: HCS1_ZYMTI
Sequence: MAARPNNIGIKAIELYFPSQCVDQAELEKFDGVSAGKYTIGLGQTRMSFCDDREDIYSLTLTTVSSLLRKYNIDPKSIGRLEVGTETLLDKSKSCKTVLMQLFEPCGNTNIEGVDTVNACYGGTNALFNTLNWMESSAWDGRNAIVVAGDIALYKKGNARPTGGAGCVAMLIGPDAPLVIEPGLRGSFVKHAYDFYKADLTSEYPLVDGQYSIKCYTEAVDKCYEAYNGREKTLKSQANGHSNGVDAAQEAPLDRFDYMCFHAPTCKLVSKSYARLLYNDYLADPTNELFKEVPAELKDLSYEASITDKTVEKTFMGLAKKRFAQRVQPSIQVPTMCGNMYCASVYASLVSLISNVSSADFQGKRVGIFSYGSGLASSLFSLKVKGSTEEITKNLNLQERLDARRVVAPEVYDEMCNLREKAHLQKDFKPKGSVDTILPNTYYLTNVDDMFRREYEVKKE
What is the function of this protein?
Hydroxymethylglutaryl-CoA synthase involved in the biosynthesis of a ferrichrome A-like siderophors which may contribute to organismal virulence (Probable).  The first step of siderophore biosynthesis is performed by the HMG-CoA synthase (HMGS) MYCGRDRAFT_54740 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (By similarity).  The enoyl-CoA isomerase/hydratase MYCGRDRAFT_76805 then catalyzes the conversion of HMG-CoA to methylglutaconyl-CoA (By similarity).  The acyltransferase MYCGRDRAFT_85486 then fuses methylglutaconyl-CoA with hydroxyornithine to yield methylglutaconyl hydroxyornithine (By similarity).  Methylglutaconyl hydroxyornithine is then available for use by the nonribosomal peptide synthetase NRPS2 to generate the ferrichrome A-like siderophore (By similarity).
What are the official names of this protein?
Hydroxymethylglutaryl-CoA synthase MYCGRDRAFT_54740, HMG-CoA synthase MYCGRDRAFT_54740, 3-hydroxy-3-methylglutaryl coenzyme A synthase MYCGRDRAFT_54740, Ferrichrome A-like siderophore biosynthesis protein MYCGRDRAFT_54740.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Protein: PELB_ASPNG
Sequence: MHYKLLFAAAAASLASAVSAAGVVGAAEGFAHGVTGGGSASPVYPTTTDELVSYLGDNEPRVIILDRTFDFTGTEGTETTTGCAPWGTASQCQVAINLHSWCDNYQASAPKVSVTDKAGILPITVNSNKSIVGQGTKGVIKGKGLRVVSGAKNVIIQNIAVTDINPKYVWGGDAITVDDSDLVWIDHVTTARIGRQHIVLGTSADNRVTISYSLIDGRSDYSATCNGHHYWGVYLDGSNDMVTLKGNYFYNLSGRMPKVQGNTLLHAVNNLFHNFDGHAFEIGTGGYVLAEGNVFQDVNIVVETPISGQLFSSPDANTNQQCASVFGRSCQLNAFGNSGSMSGSDTSIISKFAGKTIAAAHPPGNIAQWTMKNAGQGK
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity).
What are the official names of this protein?
Pectin lyase B, PLB.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FL3H1_ORYSJ
Sequence: MAPVATTFLPTASNEATLRPSFVRDEDERPRVAYNQFSDAVPVISLQGIDEAARAEIRARVAGACEEWGIFQVVDHGVDAGLVADMARLARDFFALPPEDKLRFDMSGGKKGGFIVSSHLQGEAVKDWREIVTYFSYPVKSRDYSRWPDKPAGWRAVVEQYSERLMGLACKLLGVLSEAMGLDTNALADACVDMDQKVVVNFYPKCPQPDLTLGLKRHTDPGTITLLLQDLVGGLQATRDAGKTWITVQPIPGSFVVNLGDHAHYLSNGRFKNADHQAVVNSDCCRLSIATFQNPAPDAMVYPLAVRDGEEPILEEPITFAEMYRRKMARDLELAKLKKKAKEQRQLQQAALPPPPPTQVAAELAAQKPKSLDEILA
What is the function of this protein?
Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.  Converts (2S)-eriodictyol to (+)-taxifolin and (2S)-naringenin to (+)-(2R/3R)-dihydrokaempferol in vitro.
What are the official names of this protein?
Flavanone 3-dioxygenase 1, Flavanone 3-beta-hydroxylase 1, Flavanone 3-hydroxylase 1, OsF3H-1.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: SYR_HAEI8
Sequence: MNIQSILSDKIKQAMVIAGADQSCDALVRQSGKPQFGDYQANGIMAAAKKLGLNPREFAQKVLDNLQLSDIAEKLEIAGPGFINIFLNPTWLTTEISAALSHKNLGIQATNKQTVVIDYSSPNVAKEMHVGHLRSTIIGDAVARTLEFLGHNVIRANHVGDWGTQFGMLIAYLEKMQNEHASEMELQDLEAFYREAKKHYDEDEIFAEKARNYVVKLQSGDEYCRTMWKRLVDITMQQNQHNYNRLNVTLTEKDVMGESLYNPMLPSIVEDLKKQGLAVENDGALVVYLDEFKNKDGDPMGVIVQKKDGGFLYTTTDIAAAKYRYETLKANRALVFSDTRQSQHMQQAWLITRKAGYVPDSFSLEHKNFGMMLGKDGKPFKTRTGGTVKLADLLNEAIERATVLINEKNTNLSNDEKQAVIEAIGIGSVKYADLSKNRTTDYVFDWDNMLSFEGNTAPYMQYAYTRIRSIFNKTDINSTALLAAPLTIKDDKERTLAIKLLQFEEAVQTVGKEGTPHVLCAYLYELAGIFSSFYEHCPILNAENESIKLSRLKLALLTEKTLKQGLTLLGIKTVEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECB_MYCS2
Sequence: MKVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQMLLITFGRAASQELRERVRAQIVAALVALDDPSRACNDLEEYLVKTDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGVTLVESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQLRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGVLGYDDLLTRLADALEPEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRSTLVLIGDPKQAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQLGGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSRKPGNTRVIPIDQLRRHIGRDLAADISALLNSGATWCDQPVQAKDIAVITETHKDARACHAALLAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFGETAESLAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVLSWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRDWLRTQRSERGGESERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLFHDDGQRCLHVGGADPAVARAGRAEAAGDDSRLTYVALTRAQSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPDKCSPPKISDEDALERLRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSYSGLLRAAETAGVGVSSEPEVTERDDEFDDIPVVAPAEGADVPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAELATHIDAHSQHWPVEVETAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMAGGDLRGGRFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPLRGYLSGSVDAVLRVGEKFVIVDYKTNWLGTGDGTLTAADYGRRRMVEAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGAGTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP
What is the function of this protein?
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair.  Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity.  Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination.  In the holoenzyme this subunit contributes DNA-dependent ATPase activity, exonuclease activity and 3'-5' helicase activity (By similarity).  Unlike the case in E. coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB.
What are the official names of this protein?
RecBCD enzyme subunit RecB, Exonuclease V subunit RecB, ExoV subunit RecB, Helicase/nuclease RecBCD subunit RecB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: B17_VACCC
Sequence: MSRKFMQVYEYDREQYLDEFIEDRYNDSFITSPEYYSAEKYMCRYTTLNHNCVNVRRCALDSKLLHDIITNCKIYNNIELVRATKFVYYLDLIKCNWVSKVGDSVLYPVIFITHTSTRNLDKVSVKTYKGVKVKKLNRCADHAIVINPFVKFKLTLPNKTSHAKVLVTFCKLRTDITPVEAPLPGNVLVYTFPDINKRIPGYIHVNIEGCIDGMIYINSSKFACVLKLHRSMYRIPPFPIDICSCCSQYTNDDIEIPIHDLIKDVAIFKNKETVYYLKLNNKTIARFTYFNNIDTAITQEHEYVKIALGIVCKLMINNMHSIVGVNHSNTFVNCLLEDNV
What are the official names of this protein?
Protein B17.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus B17 protein family.
Protein: CDD_SALEP
Sequence: MHPRFQTAFAQLADNLQSALAPILADHHFPAMLTAEQVSTLKNTAGLDEDALAFALLPLAAACARTDLSHFNVGAIARGVSGNWYFGANMEFLGATMQQTVHAEQSAISHAWLRGEKGLAAVTVNYTPCGHCRQFMNELNSGLDLRIHLPGRAPHTLRDYLPDAFGPKDLEIKTLLMDEQDHGFTLTGDTLTQAAITAANKSHMPYSHSPSGVALECKDGRIFTGSYAENAAFNPTLPPLQGALNLLSLNGYDYADIQRAILAEKGDAALIQWDATAATLKALGCHNIDRVLLG
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RL21_VIBC3
Sequence: MYAVFQSGGKQHRVSEGQTLRLEKLDVETGATVEFDKVLLVANGEDIKVGAPLVEGGKVVAEVVQHGRGDKVKIVKFRRRKHSRKQQGHRQWFTEVKITGINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: GYRA_MYCPN
Sequence: MAKQQDQIDKIRQELAQSAIKNISLSSELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYTGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAGELLRDIDKDTVDFVANYDGEEQEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIQGLILLIDNPDCTINDLLGVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVSIEQLPTRAALVVTEIPYMVNKTSLIEKIVELVKAEEITGIADIRDESSREGIRLVIEVKRDTVPEVLLNQLFKSTRLQVRFPVNMLALVKGAPKLLNMKQALTVYLEHQLDVLIRKTQFNLKKYQERFHILSGLLIAALNIDEVIAIIKKSANNQVAMEALHERFGLDEIQARAVLDMRLRSLSVLEVNKLQTEQQELKALIEFCQQVLADKQLQLKLIKEQLTKINEQFGDPRRSEILYGISEDIDDEDLITQENVVITMSTNGYLKRIGVDAYNLQHRGGVGVKGLTTYTDDSISQLLVCSTHSDLLFFTDKGKVYRIRAHQIPPGFRTNKGIPAVNLIKIDKDEKICALISVNDYQNGYFFFCTKNGTIKRTSLSEFANILSIGKRAILFKENDVLFSVIRTSGQDDIFIGSTAGFVVRFHEDTVRPLSRAAMGVLGINLNQCEFVNGLSTSSNGSLLLSVGQNGIGKLTSIDKYRLTKRNAKGVKTLRVTAKTGPVVTTTTVFGNEDLLMISSAGKIVRISLEQLSEQRKNTSGVKLIKLKEKERLETVTIFKKEEAIKTTTATETDDVGSKQITQ
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_VIBC1
Sequence: MERITVNLAERSYPISIGAGLFEDPAYLSQILSNKNANQKVVVISNVTVAPLYAEKILSQLEQLGCDASLLELPDGEQYKSLDTFNQVMNFLLEGSYARDVVIIALGGGVIGDLVGFASACYQRGVDFIQIPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPKAVIIDTNCLSTLPEREFAAGIAEVIKYGIIYDGAFFDWLEENLDRLYALDEEALTYAIARCCEIKAEVVAQDEKESGIRALLNLGHTFGHAIEAELGYGNWLHGEAVSSGTVMAAKTSHLRGLISQEQLDRIINIMRSAKLPVHTPDTMSFDDFMTHMMRDKKVLSGQLRLVLPTGIGSAEVIADTPQDIIKQAIDFGRDI
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_DESAP
Sequence: MISTNEFRTGLTVEVDGDPCQVIEFMHVKPGKGSPFVRAKLKNLRTGAIAERTFNAGEKLPRAILERKEMQYLYNDGANYYLMDNETYDQVGLSAGQLGDGVKYLKENMIINVVYHRGQVLGVDLPNTVELTVIETTPGIRGDTASGGSKPAVLETGVVLQVPLFVEEGDVIQVDTRSGAYIKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESAA_STAAS
Sequence: MKKKNWIYALIVTLIIIIAIVSMIFFVQTKYGDQSEKGSRSVSNKNNKIHIAIVNEDQPTTYNGKKVELGQAFIKRLANEKNYKFETVTRNVAESGLKNGGYQVMIVIPENFSKLAMQLDAKTPSKISLQYKTAVGQKEEVAKNTEKVVSNVLNDFNKNLVEIYLTSIIDNLHNAQKNVGAIMTREHGVNSKFSNYLLNPINDFPELFTDTLVNSISANKDITKWFQTYNKSLLSANSDTFRVNTDYNVSTLIEKQNSLFDEHNTAMDKMLQDYKSQKDSVELDNYINALKQMDSQIDQQSSMQDTGKEEYKQTVKENLDKLREIIQSQESPFSKGMIEDYRKQLTESLQDELANNKDLQDALNSIKMNNAQFAENLEKQLHDDIVKEPDTDTTFIYNMSKQDFIAAGLNEDEANKYEAIVKEAKRYKNEYNLKKPLAEHINLTDYDNQVAQDTSSLINDGVKVQRTETIKSNDINQLTVATDPHFNFEGDIKINGKKYDIKDQSVQLDTSNKEYKVEVNGVAKLKKDAEKDFLKDKTMHLQLLFGQANRQDEPNDKKTTSVVDVTLNHNLDGRLSKDALSQQLSALSRFDAHYKMYTDTKGREDKPFDNKRLIDMMVDQVINDMESFKDDKVAVLHQIDSMEENSDKLIDDILNNKKNTTKNKEDISKLIDQLENVKKTFAEEPQEPKIDKGKNDEFNTMSSNLDKEISRISEKSTQLLSDTQESKTIADSVSGQLNQLDNNVNKLHATGRALGVRANDLNRQMAKNDKDNELFAKEFKKVLQNSKDGDRQNQALKAFMSNPVQKKNLENVLANNGNTDVISPTLFVLLMYLLSMITAYIFYSYERAKGQMNFIKDDYSSKNHLWNNVITSGVIGTTGLVEGLIVGLIAMNKFHVLAGYRAKFILMVILTMMVFVLINTYLLRQVKSIGMFLMIAALGLYFVAMNNLKAAGQGVTNKISPLSYIDNMFFNYLNAEHPIGLALVILTVLVIIGFVLNMFIKHFKKERLI
What is the function of this protein?
Component of the type VII secretion system (Ess).  Provides together with EssB and other components such as EssC and EssE a secretion platform across the cytoplasmic membrane in the host.
What are the official names of this protein?
Type VII secretion system accessory factor EsaA.
What is the protein family that this protein belongs to?
Belongs to the EsaA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS13_LARHH
Sequence: MARIAGVNIPNHQHIWVGLQAIYGIGATRAKVICSAAGIEISTKVKDLTDAEMEKLRDEIAKFTIEGDLRREVTMNIKRLMDLGCYRGFRHRRGLPCRGQRTRTNARTRKGPRKPIAGKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: HTPX_ACIBT
Sequence: MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLVSLFMSKWMAKKTTGTELIDPNAPRNQAESWLLQTVAELSQRAGINMPEVGIFPSYQSNAFATGWNKNDALVAVSSGLLERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMFFARVVGDFIDRNVFGRQDNEAPGMGYFIITMVLDIVFGILASAIVMWFSRYREYRADEAGARLAGKQAMISALLRLQAETELPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPTIEQRVAALHQLDCP
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CUTA_ECOLU
Sequence: MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AREA_PENRO
Sequence: MDGIHHGGHGRARPSHPMAFPDFDADSHMMSDDFSLDTPFSPSGSSNANDTVLGNSIFPEWTNGVSRGDSPDEMQRKDPLGAQIWKLYTRTKSQLPNQERMENLTWRMMAMNLKRKEREQQARASETLSPTPSGIAQMRLSDQPSPAGGDLAHDTTSDPMNLDDFIVPFDSPAEHSSHPIDRHFTATPTGSIPIKSRKDHAMMDSSTAASFPHPPQDQRTNSEFGYVARRVRKTSVDDRQFFAGLSVPTRKRPAEASPQVPPVSNAMMAQHSELSSALPDYSLDHPPSAYALSGNGTVGPRRPQHHHTHSNIPYGLDTYGISENHGLNSAGSYQQNFHFSPSDSPMTAGNPFSSLYAQTPLASSLNSTEFFSPPPSGYQSTVSTPQPIYEGEQSIFFSDAPSAESHTQRRIPNYIQQRQSNLSASLQPRYMYNMSNGESHSGSAVTGPPTTHVSGFSVPPPQHINPSQVLGHGEFSTTAPSSSMFTFGGDSDNEDDDGNFGEGGGMTMPNDFASLDESGDMSAGLHWDGGFPGSIHSLPGFNAQHRKHVTIGSTDMIDGPPEWNQGGTLGRAHGSAASVSEVRNQNQDPRRYGKVPRTASTPNAAALLRQSLNGSASGPPTNHPSPSTPPESGLSSAVPSRPGSPGGSKNGDPNAGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSSASTLAVGTSRSSKKSSRKNSIQHAPSTSISSRMNTSESPPSMNGSSSLGKTGVVPIAAAPPKSGPPAGVAQARAGVQVAPRRQRRLEKAPTGSDPDAKDSPKSAAPPSRSKVLPLAPAMAPPAAANPANHNIAGGQGASQEWEWLTMSL
What is the function of this protein?
Major nitrogen regulatory protein.
What are the official names of this protein?
Nitrogen regulatory protein areA, Nitrogen regulator nmc.
What are the subcellular locations of this protein?
Nucleus.