PharMolix/UniProtQA huggingface dataset:
Protein: GLOX_PHACH
Sequence: MLSLLAVVSLAAATLAAPAASDAPGWRFDLKPNLSGIVALEAIVVNSSLVVIFDRATGDQPLKINGESTWGALWDLDTSTVRPLSVLTDSFCASGALLSNGTMVSMGGTPGGTGGDVAAPPGNQAIRIFEPCASPSGDGCTLFEDPATVHLLEERWYPSSVRIFDGSLMIIGGSHVLTPFYNVDPANSFEFFPSKEQTPRPSAFLERSLPANLFPRAFALPDGTVFIVANNQSIIYDIEKNTETILPDIPNGVRVTNPIDGSAILLPLSPPDFIPEVLVCGGSTADTSLPSTSLSSQHPATSQCSRIKLTPEGIKAGWQVEHMLEARMMPELVHVPNGQILITNGAGTGFAALSAVADPVGNSNADHPVLTPSLYTPDAPLGKRISNAGMPTTTIPRMYHSTVTLTQQGNFFIGGNNPNMNFTPPGTPGIKFPSELRIETLDPPFMFRSRPALLTMPEKLKFGQKVTVPITIPSDLKASKVQVALMDLGFSSHAFHSSARLVFMESSISADRKSLTFTAPPNGRVFPPGPAVVFLTIDDVTSPGERVMMGSGNPPPTLE
What is the function of this protein?
Catalyzes the oxidation of aldehydes to the corresponding carboxylic acids by coupling the reaction to the reduction of dioxygen to hydrogen peroxide.  Substrates include, methylglyoxal, glycolaldehyde, acetaldehyde, formaldehyde and glyoxal.  May act as a source of extracellular hydrogen peroxide required for the oxidation reactions catalyzed by the lignin peroxidases (ligninases) and manganese peroxidases, both involved in lignin degradation.
What are the official names of this protein?
Aldehyde oxidase GLOX, Glyoxal oxidase, GLOX.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_BRASB
Sequence: MEVILLERVAKLGQMGEIVKVKDGFARNFLLKRKKALRATAENKAKYEGMKAELEANNIKAKGEAAKVAEKIDGRDIVIIRQASESGQLFGSVSVRDIVVALAADGITVSRPQVWLDAPIKAIGQQKITIAIHPEVETSVTVTVARSADEAERIKRGEDISTRQEDRDAAAEAIAAAGEFFDPEAQEDEAAAGETAQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TXLA_SYNE7
Sequence: MTADNSVPSRLRNILVIAAALVLTILVVLGSRQPSAAASLASLAEQATPYEVAIANDRPMLLEFYADWCTSCQAMAGRIAALKQDYSDRLDFVMLNIDNDKWLPEVLDYNVDGIPQFVYLNGQGQPQGISIGELPRSVLAANLDALVEAQPLPYTNARGNLSEFSADLQPSRSSQTDPRSHSGQVQDGVLD
What is the function of this protein?
Required for disulfide bond formation in some proteins.  Acts by transferring its disulfide bond to other proteins and is reduced in the process.
What are the official names of this protein?
Thiol:disulfide interchange protein TxlA.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HSP7C_CAEBR
Sequence: MKTLFLLGLIALTAVSVYCEEEEKTEKKETKYGTIIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFSGEQGDRLIGDAAKNQLTINPENTIFDAKRLIGRDYNDKTVQADIKHWPFKVLDKSNKPSVEVKVGADNKQFTPEEVSAMVLVKMKEIAESYLGKEVKHAVVTVPAYFNDAQRQATKDAGTIAGLNVVRIINEPTAAAIAYGLDKKDGERNILVFDLGGGTFDVSMLTIDNGVFEVLATNGDTHLGGEDFDQRVMEYFIKLYKKKSGKDLRKDKRAVQKLRREVEKAKRALSTQHQTKVEIESLFDGEDFSETLTRAKFEELNMDLFRATLKPVQKVLEDSDLKKDDVHEIVLVGGSTRIPKVQQLIKEFFNGKEPSRGINPDEAVAYGAAVQGGVISGEEDTGEIVLLDVNPLTMGIETVGGVMTKLISRNTVIPTKKSQVFSTAADNQPTVTIQVFEGERPMTKDNHQLGKFDLTGIPPAPRGVPQIEVTFEIDVNGILHVTAEDKGTGNKNKITITNDQNRLSPEDIERMINDAEKFAEDDKKVKEKAEARNELESYAYSLKNQIGDKEKLGGKLDEDDKKTIEEAVDEAISWLGSNADASAEELKEQKKELEGKVQPIVSKLYKDGGAGGEEAPEEGSDDKDEL
What is the function of this protein?
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
What are the official names of this protein?
Heat shock 70 kDa protein C.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: KPTA_CLOPE
Sequence: MKNNDSKISKYISLILRHKPEEIGLKLDEHGYLGVLDLIEGLNKSYKGFSMDDLERIVREDSKGRYSFNEDKSKIRANQGHSIKVDLGLEAIKPPKVLYHGTGRKYIESILKNGLIKKERQYVHLSKDIETASIVGKRHGDLVILEVDSESMFKDGIKFYLSKNNVWLCDYVKVEYIKEISLL
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: NDHI_PSIGN
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIDDYTIRTILNLSEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TRPF_RHOCS
Sequence: MPVQVKICGINRPDALAAAVAGGARYVGLVFYERSPRHVAPELAAELARQVPTGVRVVGLFVDPDALMLERVLGSVPLDLIQLHGEETPERVAAVRAAHGIEVMKAVKVAGAADLDRAAAYEGACDRLLFDAKAPKGVAALPGGNGLSFDWTLLAGRTWARPWMLSGGLNAGNLAEAVRATGATAVDVSSGVEDRPGHKDPALVAGFLACAAAL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: I18BP_HUMAN
Sequence: MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG
What is the function of this protein?
Isoform A binds to IL-18 and inhibits its activity.  Functions as an inhibitor of the early TH1 cytokine response.
What are the official names of this protein?
Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa.
What are the subcellular locations of this protein?
Secreted.
Protein: UREF_RHILO
Sequence: MTDQPSSIALLRLMAWLSPAFPVGGFAYSHGLECAVHDGLVADATSLANWLETLVKMGSGWNDAVLFCESWRRARNAGDLDEVAALAEALAGSRERHAETMLQGAAFLKAAAAWPNPVLARLPAECAYCVTVGAIAGGNGIALQDALSAFLQAFFSNLVQAAIRLGVVGQSEATTLLAGFEPLALSTADRASRSTLDDLGGCAFVSDVVAMKHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATA_METM6
Sequence: MVVGKIIKISGPVVVAEGMKGSQMFEVVKVGNEGLTGEIIQLTEDEAIIQVYEETAGIKPGEGVTGTGAPLSVELGPGMLKAMYDGIQRPLNEIENATDSIYIPRGVSVPSISREIKWDFEPIAAVGDEVITGDVIGTVQETASIVHKIMIPFGVSGKIKEIKAGSFTVEETIAVVETAEGEKEIMMMQKWPVRKPRPSKGKQAPVIPLITGQRVEDTFFGLAKGGASAIPGPFGSGKTVTQHQLAKWSDVDVVVYIGCGERGNEMTEVIEEFPHLDDIKTGNKLMDRTVLIANTSNMPVAAREASVYTGITIAEYFRDQGLGVLLTADSTSRWAEAMREISGRLEEMPGEEGYPAYLSSKLAQFYERAGRVECLGSENKQGFVCIVGAVSPPGGDFSEPVTSNTLRIVKVFWALDANLARRRHFPAINWLTSYSLYIDDIAGWWQQNTAADWRSLRDEAMSLLQKEAELQEIVQLVGPDALPDRERVILEIARMLREDFLQQDAYHEVDSYCSPIKQYHMLKIIMTFYKKGLDAVAKGADPAGISAVTVKGDIARMKYLVEDEFVNTKVPEIINKMESELGALIK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: YQAD_BACSU
Sequence: MKNNDKKKEVQRKYREEIKKKKQKNEDNKNFIKETIIVVTIIVLFIFFTYTLQGF
What are the official names of this protein?
Uncharacterized protein YqaD.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL27_PARL1
Sequence: MAHKKAGGSSRNGRDSAGRRLGVKKFGGESVIPGNIIIRQRGTKWHPGRNVGIGKDHTIFAKSEGVVEFRNGKNGRSFVSVVVPAEMPAKAAD
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RNH_SALG2
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAILRYRGHEKTFSEGYTLTTNNRMELMAAIVALEALKEHCEVTLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWKRLDAALGQHQIKWVWVKGHAGHPENERCDELARAAAMNPTQEDSGYQAEA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 2B_TOBSV
Sequence: MFIPILFLTLTLASADVMTLMESEPQPSTTESRPSMPPINSGKPSVTEKPGVELNPGETVKVKAEQFNTVNPVELKLEKRIPPGRVGSNCIDCAISNLPKAMFSVKVPKLNINFEVSDFPSSRLIFATLAQRVKSIPFIESLSFPSDIQRMQLRALGDVEVLIFIPKFGWKQILKLSDVVSGFDIPKIPSIAPKVESCVGDCLNS
What is the function of this protein?
Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May directly interfere with the mobile silencing signal (By similarity).
What are the official names of this protein?
Suppressor of silencing 2b, Protein 2b.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus/ilarvirus protein 2b family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: VAC14_BOVIN
Sequence: MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAKQEGAASGGPDGSCDSSFSSGISVFTPASAERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTELFQLRNQLKDLKTPESRNLFCCLYRSWCHKPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDGLKAAPKSQKADSPSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRRVVL
What is the function of this protein?
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Pentamerizes into a star-shaped structure and nucleates the assembly of the complex.  The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P).  Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
What are the official names of this protein?
Protein VAC14 homolog.
What is the protein family that this protein belongs to?
Belongs to the VAC14 family.
What are the subcellular locations of this protein?
Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Protein: RL3_BIFAA
Sequence: MSNRTALLGKKLGMSQVWDENGFFVPVTLVDVSTNVVTAVKSEESDGYKAVQLGYGQVDPTKVTKPLAGHFAKAGVTPRRHLAEVRTDNAEEFEPGQELTAELFPEGTLVDVTGTTKGKGFAGTIKRWGFKSYRRTHGSHKNERRPGSVGACATPSRILKGKRMAGRMGHVTNTALNLTIVSSDVENGVLAIKGAIPGPKGSIVLVRSAVKGA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: DOHH_DROPS
Sequence: MVSQEQIEAIGGVLNNKDRPLKERFRALFTLKNIGGKTAIDAISKAFDDDSALLKHELAYCLGQMQDPTALEILTKVLKDTTQEPMVRHEAAEAMGAIGHADVLAILEEYKKDPVVEVAETCAIALDRVRWLQSGQQVADNNPYASVDPSPPTAGDKSVAELKAIYLDAKQTLFDRYRAMFSLRNLCTEESVLAIAEGLKDSSALFRHEVAFVLGQLQEPCSIPYLQENLEDHKENEMVRHECAEALGAIATDDCIQILTRYADDEKRVVKESCVIALDMCEYENSPEFQYADGLSKLDGTK
What is the function of this protein?
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.  Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis.  Has a role in eIF-5A-mediated translational control.
What are the official names of this protein?
Deoxyhypusine hydroxylase, DOHH, Deoxyhypusine dioxygenase, Deoxyhypusine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine hydroxylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In larval imaginal disk and Garland cells.
Protein: HFAB_CAUVC
Sequence: MMVKRTGAVLALLATAALSACGSTPVASTAGNYAKPIGTAPVTANPTDYSSALVCLNQYARTNRIVAPRIAIGRIADYTGKEESDGSGRKVTQGASLMAVSAFAKAGMPLVERFDTSVSEFELKYANNKLISDRPNPAPDAPADFRKILAGQVPGSDFYVIGGITELNYNIRSAGIDAYAGDKDTDGLKGNFRRRVFIMNIALDLRLVNTRTLEVVDVISYQKQVVGREVSAGVFDFLNGNLFDISAGRGALEPMQLAVRALIERATVEMAANLYGMPGPESCLRFDPFGDATVGQTGAFTPAYNNLGTNNAQTRDDPSRWNARRDPDIRDAKRGRY
What is the function of this protein?
Required for the attachment of the holdfast to the cell.  May be involved in the positive regulation of hfaC.
What are the official names of this protein?
Putative transcription activator protein HfaB.
Protein: GALT2_STRPN
Sequence: MTLVNKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNLDKLIDLKDQLVEEAVRLETIEDSQTAREILGAELMDLVTPCPSQVNRDFWATYAHSPEQAIEDFYQLSQKNDYIKLKAIARNIAYRVPSDYGELEITINLSKPEKDPKEIVAAKLVQASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFLDGQHRPMAISRQSFERLLAIVDQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPMELAPLQKAFRFAGFEQVKAGIVKWPMSVLRLTSDSKEDLINLADKILQEWRQYSDPAVQILAETDRTPHHTITPIARKRDGQFELDLVLRDNQTSAEYPDGIYHPHKDVQHIKKENIGLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKALAIVKDSVGAIFARVLEDAGVYKQTEQGQTAFMRFVEQVGILLD
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase 2, Gal-1-P uridylyltransferase 2, UDP-glucose--hexose-1-phosphate uridylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL40_HUMAN
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
What is the function of this protein?
Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547).  Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547).
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40, CEP52, Ubiquitin A-52 residue ribosomal protein fusion product 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: ATPA_ACIF5
Sequence: MQQLNPSEISELIRARIAGFEGRVETRSQGTIISLSDGILRIHGLEDVMYGEMLELPGGRFGLAMNLEQDNVGAVVLGEFSGLQEGDVVKCTGRVMQVPIGKALLGRVVNALGQPVDGKGAIDAEEFDVLEKIAPGVIDRQSVDEPMQTGIKSIDAMVPIGRGQRELIIGDRQTGKTAVAVDAILNQKGKDVQCIYVAIGQKASTVAGVVRKLEEYGAMEYTTVIAANASESAAMQYLAPYAGCTMGEYFRDRGMNALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNADFVEKFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLFNAGIRPAINAGLSVSRVGGAAQTKIIKKLGGGIRLDLAQYRELAAFAQFASDLDEITRKQIERGKRVTELLKQDQFSPMSVAEQGAALFAASSGALDDVEVANVRPFEKALLAYLNSNNKELMAGIEEKKDLTDDLKKQLDAAVKQFKSGSTY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GRAA_BOVIN
Sequence: MNIPFPFSFPPAICLLLIPGVFPVSCEGIIGGNEVAPHTRRYMALIKGLKLCAGALIKENWVLTAAHCDLKGNPQVILGAHSTSHKEKLDQVFSIKKAIPYPCFDPQTFEGDLQLLQLEGKATMTKAVGILQLPRTEDDVKPHTKCHVAGWGSTKKDACQMSNALREANVTVIDRKICNDAQHYNFNPVIDLSMICAGGRKGEDDSCEGDSGSPLICDNVFRGVTSFGKCGNPQKPGIYILLTKKHLNWIKKTIAGAI
What is the function of this protein?
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse.  It cleaves after Lys or Arg.  Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity.  Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
What are the official names of this protein?
Granzyme A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule. Note=Delivered into the target cell by perforin.
Protein: DAPF_RICCK
Sequence: MISKINFVKMHGLGNDCVIVNKRDLLNAHNLSQLAKNIADRHTGIGCDQFIIYENHNNFYEMIIYNIDGSSAKLCGNATRCLAKLIYLDTGKKDITIVVGNKELLCRIEDENKISVNVGAVSFNETWMPSRDKIWAFAARYMIDLKETICVDVGNPHLVIFSKLESQDQKIVGETLQAKELFANGVNVNFAEIKDNKINLSVWERGVGLTGACGSGACGSFAAGLKRGFIHSPSTVVFKHGSLNMKEENGNIIMQGSATLIAEGVYCCE
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR23_ARATH
Sequence: MEIERKLLRLLHGHNTRTRLPEIHAHLLRHFLHGSNLLLAHFISICGSLSNSDYANRVFSHIQNPNVLVFNAMIKCYSLVGPPLESLSFFSSMKSRGIWADEYTYAPLLKSCSSLSDLRFGKCVHGELIRTGFHRLGKIRIGVVELYTSGGRMGDAQKVFDEMSERNVVVWNLMIRGFCDSGDVERGLHLFKQMSERSIVSWNSMISSLSKCGRDREALELFCEMIDQGFDPDEATVVTVLPISASLGVLDTGKWIHSTAESSGLFKDFITVGNALVDFYCKSGDLEAATAIFRKMQRRNVVSWNTLISGSAVNGKGEFGIDLFDAMIEEGKVAPNEATFLGVLACCSYTGQVERGEELFGLMMERFKLEARTEHYGAMVDLMSRSGRITEAFKFLKNMPVNANAAMWGSLLSACRSHGDVKLAEVAAMELVKIEPGNSGNYVLLSNLYAEEGRWQDVEKVRTLMKKNRLRKSTGQSTICDVSV
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g09190.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: LGT_STRPI
Sequence: MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPDDILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLYIFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMYIEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMRTDSLMFFGLRVSQWLSVVLIGLGIMIVIYQNRKKAPYYITEEEN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDHC_FELCA
Sequence: MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALEKYAKKSVKVIVVGNPANTNCLTACKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVSHAKVKLHGKEVGVYDALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNPYGVPDDLLYSFPVTIKNKTWKVVEGLTINDFSREKMDLTAKELAEEKETAFEFLSSA
What is the function of this protein?
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH.  Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation.
What are the official names of this protein?
Malate dehydrogenase, cytoplasmic, Aromatic alpha-keto acid reductase, KAR, Cytosolic malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUQ_SALTI
Sequence: MTDSHYIGRFAPSPSGELHFGSLIAALGSYLQARAQRGVWRVRIEDIDPPREVPGAAATILRQLEHYGLHWDGEVLWQSQRHEAYREALAWLHEQGLSYYCTCPRSRIQRLGGIYDGHCRTLCHGPENAAVRIKQQHPVMHFHDALRGDIQADPQLASEDFIIHRRDGLFAYNLAVVVDDHFQGVTEIVRGADLIEPTVRQLSLYKQFGWRAPGYVHLPLALNEQGAKLSKQNHAPALATGDPRPVLVQALRFLGQRDVVAWQEMSVEELLRFAVAHWRLTAVPTSANVNPAFSNASR
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: PSD2_MOUSE
Sequence: MDEEKLPCELHKEGSATQEDHGLEPEEEPGLQNGTAASEGLSSHISGPGGEKTLEGTMEPVRGPDVALPGLNLSLTNGLALGQDGNILEDSIEFKTWRSGPAEEEDVPGSPCPDAGDPQLGLDCPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDVLSLTDESDSCVSFEAPLTPLIQQRARDSPEAGAGLGNGDMGPEGDLGATGGCDGELGSPLRRSISSSRSENVLSHLSLTSVPNGFHEDGPGGSGGDDEDDEDTDKLLNSASDTSLKDGLSDSDSELSSSEGLEPGSTDPLANGCQGVSEAARRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDRALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALNATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRLDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQVTAELAEHRCHPLERGLKSKEAEEYRLKEHYLTFEKSRYETYIHLLAVKIKVGSDDLERIEARLATIEGDDPALRKTHSSPALSLGHGPVTGSKATKDTSASDT
What are the official names of this protein?
PH and SEC7 domain-containing protein 2, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C, Exchange factor for ARF6 C, Pleckstrin homology and SEC7 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the PSD family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cell projection, ruffle membrane. Cleavage furrow. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body.