PharMolix/UniProtQA huggingface dataset:
Protein: SPT4H_HUMAN
Sequence: MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT
What is the function of this protein?
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.  DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A.  DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter.  Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex.  DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II.  TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme.  Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites.  DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat.  DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
What are the official names of this protein?
Transcription elongation factor SPT4, hSPT4, DRB sensitivity-inducing factor 14 kDa subunit, DSIF p14, DRB sensitivity-inducing factor small subunit, DSIF small subunit.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
Protein: SYI_XANCP
Sequence: MTQDYKATLHLPATDFPMRGDLPKREPAMLERWEREGLYAQVRANAAGRPLFVLHDGPPYANGQIHLGHAVNKILKDIIVKSKYLAGFDAPYIPGWDCHGLPIEIAIEKKFGKVGVKLDAAQFRQKCREYATEQIDLQRRDFKRLGVIGDWDNPYKTLDFRFEANEIRALAKVIDNGHLTRGVKPVHWCFDCGSALAEAEIEYADKLSPTVDIAYPARDPAAIAAAFGVTLPAGTQVAVPIWTTTPWTLPASLAVSLGAELDYVLVEGPADRGQPRWLVIAEALAGKALARYGVEAVVVHGHAKGAALDQLLLAHPFYAERDIPLILGDHVSDDDGTGAVHTAPGHGQEDYQVSKQYGLLERYSAAQINPIDGRGVYLPSTPPLGDTVLAGLHIWKANDVIIDALRDTGVLLAASTMEHSYPHCWRHKTPIAFRATPQWFISMEQANLRADALKAIETVHWYPSWGQARIAGMIDGRPDWTISRQRTWGVPIALFVHRETGEPHPRSTELMRQVAERVEQGGVDVWYTLDAAELLGDEAGDYDKITDILDVWFDSGVTHEAVLVDRGLPKPADLYLEGSDQHRGWFQSSLLTGVAMDKVAPYKQCLTHGFTVDEHGRKMSKSLGNGIEPQEIMRTLGADILRLWIASADYSNEMSLSQEILKRNADAYRRLRNTARFLLGNLHGFDPLQHLVALDDMVLLDRWIVHRAHELQEKITAAYARYDFAEIVQALLNFCSVDLGSLYLDVTKDRLYTMAEDARGRRSAQSAMYHVAEAFVRWIAPVLSFTAEELWAYLPGEHSGNVLFATWYDGLAPMPADAALTSADVDKLLALREQVAKVLEPMRANGAIGAALEAEITVAADAQTAARWQPLSDELRFLFISGDVTVTAASTDDIFVSAQPTTKAKCVRCWHHQASVGSDPRHPELCSRCVSNIEGPGEERRWF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_BRADU
Sequence: MAVYTDVAADELADFLSQYDLGELLSYKGIAEGVENSNFLLHTTKGSFILTLYEKRVAKNDLPFFLALMTHLAEHGVNCPLPVKGRDGEALRELSGRPAAIITFLEGVWPRKPNAAHCAGVGEGLARMHLAGANFAIRRANALSVAGWRPLFDAAASRADEVQPGLRAFLAAELDYLASGVWPTNLPEGVIHADLFNDNVFFLGDKLSGIIDFTFACNDMLAYDVAICLNAWCFEPDHSFNVTKARAFLNAYGRVRKLSEAEEAALPLLARGAAIRFLLTRLVDWLNVPPGALVRPKDPLEYVRKLRFHQSVSSVRDYGLMPSGLVA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: UREG_ENT38
Sequence: MADYKHPLRVGVGGPVGSGKTALLEALCKAMRDQYQLAVVTNDIYTKEDQRILTEAGALEPDRIVGVETGGCPHTAIREDASMNLAAVETLSEKFGNLDLIFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITKSDFLVINKTDLAPYVGASLEVMERDTNRMRGERPWTFTNLKVGDGLNKIIGFLEDKGMLKV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MO2R1_RAT
Sequence: MLCFWRTSHVAVLLIWGVFAAESSCPDKNQTMQNNSSTMTEVNTTVFVQMGKKALLCCPSISLTKVILITWTITLRGQPSCIISYKADTRETHESNCSDRSITWASTPDLAPDLQISAVALQHEGRYSCDIAVPDGNFQNIYDLQVLVPPEVTHFPGENRTAVCEAIAGKPAAQISWTPDGDCVAKNESHSNGTVTVRSTCHWEQSHVSVVFCVVSHLTTGNQSLSIELGRGGDQLLGSYIQYIIPSIIILIIIGCICLLKISGCRKCKLPKSGATPDIEEDEMQPYASYTEKSNPLYDTVTTTEAHPASQGKVNGTDCLTLSAMGI
What is the function of this protein?
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein.  Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity).
What are the official names of this protein?
Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, OX102 antigen.
What is the protein family that this protein belongs to?
Belongs to the CD200R family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MUTL_AFIC5
Sequence: MPVRQLPEQIVNRIAAGEVVERPASAVKELVENAIDAGGTRIDIFTEGGGRRRIVITDDGSGMTQGDLALAVERHATSKLDDEDLLRIRTLGFRGEALPSISSVAKLAITTRHAAEPHAWAVEVDAGAKSAIAPAALQRGTRVEVSDLFYATPARLKFLKTDRTEAEAIREVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGRLTRLGDILGSDFRTHAIEVGSEREGVSVEGFAAAPSLTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPIVALFVTLDPQEVDANVHPAKTEVRFRNAGLVRALIVHALKDGLAREGRRTAANTNGAAITTAFRTEGFSREGFARESLPRGGYDWRSSPAAPWPPQAAAQAPAMGFDESAQAAFDAGAPSADTRGNEAPLGDALGRPLGAARTQIHENYIVAQTNDGLILVDQHAAHERIVYERLKASLTKNGVARQMLLIPEIVEMDEASVEKLLARASELEKYGLSIESFGPGAVAVRETPALLGKANAASLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRSGRILKVEEMNALLREMEATPNSGQCNHGRPTYVELKLADIEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RK20_GUIAB
Sequence: MTRIRRGYIARRRRTKIRLFASSFRGAHSRLTRTITQQKIRALVSAHRDRDRQKINFRRLWITRINAAIRERGVCYSYSRLINDLYKRQLLLNRKILAQIAISNRNCLYMISNEIIKEVSWKESTG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MPAH_PENRF
Sequence: MSSEKFTVTEHLVPGSYIREYPGSTVTQEDVLKIHVKQYTPKHEGPVPADAITFIAAHGVGLPKELYEPLWDELLERTNGFHIHGIWVADVASMNQSGIQNEDKLSMDCSWMDHPRDLFLMINHFREQMPRPLVGVGHSFGGNIITNLAYLHPRLFTTLLLIDPLIQLSPPSMGFGTDPPGPINYTLWRNDVWPSREAAIRANRGLIHGWDPRCVDRMAKYFFRDLPTPLYPDVEAVKARFDAAADTTATPVTLATPKYHELIAQIRQNFNARDPTTGRIEIPRATHADMDPLVASIPLYRPEPRSTFRRLGTLRPSCLWIVGGATFLNVDEIHEGVKICGSGIGGSGGVSEGRVKEVILPGLGHLMPFQEIGTVVGPCVAWLQQEMDRFRQMEREWGEERKGKSHLVLEKNWYKVLKPMPSGRGKGGRKEKL
What is the function of this protein?
Type I acyl-CoA thioesterase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:26751579).  MpaH acts as a peroxisomal acyl-CoA hydrolase that converts MPA-CoA into the final product MPA (By similarity).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (PubMed:26751579) (Probable).
What are the official names of this protein?
Type I acyl-CoA thioesterase mpaH, Mycophenolic acid biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MpaH hydrolase family.
What are the subcellular locations of this protein?
Peroxisome matrix. Note=The mpaH' location in peroxisomes is required for the unique cooperation between biosynthetic and beta-oxidation catabolism machineries to produce final MPA.
Protein: PSUG_COPPD
Sequence: MLQIAPHVKEAIETLKPVVALESTIITHGMPYPANLHTALEVEQVIKEAGAVPATIGVINGIIKVGLSEEEITYLSQAKDLHKISLKDLSVAAAKKLSGGTTVSATMFASYKAGIQVFATGGIGGVHRDARESFDVSTDLEALGSIPITVVCAGAKAILDLPATLEYLETKGVLVVGYKTDEFPAFYYGRSGLKLEHSVTTPGELAQIIRERDALEINKAILVGNPPPEEMALEKGKVEQLIEAALQQAKVNNIKGKDVTPFLLDYLAKNSKGETLETNIALVKNNAYVGSLIAKALMAAKI
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: ABAA_ASPFU
Sequence: MATDWQPECIAPQHQSGLENIGHHTDRALQNTSGNVQSYSDAILHGGMSGRDDHLQHLAYKYSHAPVHPQPMQTATTLHPHHILNARVQAKKLRRVQSLGPNHAGARRGRSYLKSQKYLEYRARPRRDTGKDGEPVWSDELEDAFQQALEANPPMGRRKWSERGKSYGRNELIAEYIYKVTGKKRTRKQVSSHLQVLDSFLKGDPDWERLVREQPADRSGNQHQPVGPKWRTSLDHPLPSHYGGHMHATYHDHLSPVQPYVGELPPPHYTLGSNMHERSTDTIHGFNFDMWVSAPQQANQGDKAFHVYTCLQGDQYHPVAPPMPLENVRDWRTTFPHLNSVMEELDGPLDCEIILLEASLKLMNDFPPPGSKLGIQLDIDFAPPGMTDATVLSQMDNWTCSTYIYEDGNRLSKADHNLARPLSTKVKPPFESSWWAKLFTELTQDKQMAEKSGRHQNADDHIRQFFRSLSAVQEIRAISQNSRRVSQGSGHPGDCSKRMAILLWKFRQTLPDEVGLTTWRKLIPPPDRTMMNSPKPATGIDLPPLSLDSILLKPQPPNVYQNPQGHDLLHQNGTSQPHWPLYPPPHESMSNMYHSTGSFDFLNSVSKAEDGLPDRTAVTSILDSFPAMPPQETSQPSSLNVSSGGPVMLNVHDMSLSHHNLAGYALSHDNHYVPSQQHGVSVHDSSNVLNNIFGPGSQPMDEIGNSQSAWGPPIPSTTIPSDVGSNHYTHLPYHHHDHQTSASRESHPPNGFEGLMGPDDLMDKIVGSMPDDPGMNGAGPDHASAAYADTNATEAVQ
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity).  Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity).  Essential for differentiation and functionality of phialides as conidiogenous cells (PubMed:20966095).  Regulates autolysis and cell death (PubMed:20966095).  Positively regulates expression of the gliotoxin biosynthetic gene cluster in actively growing vegetative cells, and likely bridges morphological and chemical development during the life-cycle (PubMed:26032501).  Negatively regulates expression of the melanin biosynthetic gene cluster (PubMed:24123270).
What are the official names of this protein?
Conidiophore development regulator abaA.
What is the protein family that this protein belongs to?
Belongs to the TEC1 family.
What are the subcellular locations of this protein?
Nucleus. Note=localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).
Protein: NITR2_UNKP
Sequence: MGEFGEVTLGVAQAAPVYFDREASTEKARGLIREAGEKGVDLLAFGETWLTGYPYWKDAPWSREYNDLRARYVANGVMIPGPETDALCQAAAEAGVDVAIGVVELEPGSLSSVYCTLLFISREGEILGRHRKLKPTDSERRYWSEGDATGLRVYERPYGRLSGLNCWEHLMMLPGYALAAQGTQFHVAAWPNMASSASELLSRAYAYQAGCYVLCAGGLGPAPGELPDGIAAESLDHLTGESCIIDPWGKVIAGPVSCEETLITARVSTASIYRRKSLTDVGGHYSRPDVFRFEVDRSERPRVVFRDGDVDDRG
What is the function of this protein?
Nitrilases catalyze the mild hydrolytic conversion of organonitriles directly to the corresponding carboxylic acids.  Catalyzes the production of aryllactic acid derivatives.  Mediates the hydrolysis of cyanohydrin to (S)-phenyllactic acid.
What are the official names of this protein?
Nitrilase 2, Nitrilase II.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: RECX_HERSE
Sequence: MPRPPISLKARALKYLSSREHSRLELARKLAPYAQEGDDIEALLQWLEQSRFLSQERFSESLVHRRAARYGNQRILSELHGHGIEGEAIADLKADLAAGEAERAAQVLRRKFTAPPADAETRAKQMRFLQQRGFSHRSIREAFQTAWLDEDDPS
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARE_STAES
Sequence: MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEVVDNSVDEVLNGYGDAITVTINQDGSISIEDNGRGMPTGIHASGKPTAEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYTQNFKNGGIPATGLVKTGKTKKTGTKVTFKPDSEIFKSTTTFNFDILSERLQESAFLLKDLKITLTDLRSGKEREEIYHYEEGIKEFVSYVNEGKEVLHDVTTFAGHSNGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNEYARRINELKDKDKNLDGNDIREGLTAIISVRIPEELLQFEGQTKSKLGTSEARSAVDSVVSEKLPYYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTDKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRIIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKNKKVEYAWTDEELENLQKQLGKGFILQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVAPRREWIEKHVEFGMQEDQSILDNKEVQILENEKYIEEETN
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Protein: ZDHC5_CANLF
Sequence: MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLCVSPAVPIYNAIVFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHMEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRSKSKGSLEVTESQSADAEPPPPPKPDLSRYTGLRTHLTLAANEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLVKTPLGRPAAPRFGKPDGLRGRGLGSPEPGPTAPYLGRSMSYSSQKAPAGVSEAEEVALQPLLTPKDEVQLKTAYSKSNGQPKSIGSASPGPGQQPLSSPTRGGVKKVSGVGGTTYEISV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions.  Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs).  Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins.  Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2.  Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2.  Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes.  Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane.  Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis.
What are the official names of this protein?
Palmitoyltransferase ZDHHC5, Zinc finger DHHC domain-containing protein 5, DHHC-5.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHX32_XENLA
Sequence: MALSLEAYEQDIDELISDEKSCCLDVTDSSDVEGDELNDLELNPFDGLPYSSRFYKLLKERETLPIWKIKYDFLEHLAHNQIVVVSAGPKSGKSSQIPQWCAEYCLAGHYQHGAVVCTQAHKQTAVWLAMRVADEMDVNIGHEVGYIVPFENCCTSETILRYCTDEMLRREMMSNPLLSSYGVVIIDDVYERFVSTDVLLSFLKVIAVSRPELKVVIITCPSLSGTLVSYYGNAPLVEAENTHSVESVYTTSLPRDYFHSALRLLFEIHHTKEKGDIVVFLACEEEIKRAYEHIKQEALHMNPELGELMPIALYPHQSISDYIPYEELDDNSKNPKRKVVLTTSLGESLIWMKNIFFVIDVGIEKRKVYNTRIRAESLVTQPISKVRAKMRKHILSSSSEGKLFCLYPEDFAHEMKPFLTAKVEECNLISMVLFLKRMDIAGLAHCDFINRPDPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILAACEFDCVDEMLTLAAMVTAPNCFIDLPPEAKELDLIGKGKFFHPEGDHFTLINIYNEYEQMKRNNASQYDVEKWCQNHCLSFVALEMARAIRNELLDIMRRIELPLTGPAFGSDENVTNIKKSLLSGYFMQIARDVDGLGNYIMLTHKQVGQLHPDSGFCNSAKVPEWVLFHEFSVSERSCIRIVSEISPNLFMEFVPPYYFSNLPPSETKDLLQQDQTPDTPPTEEPREEEPLHEANDEGTAEQRCIIQ
What are the official names of this protein?
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: MSRA_YERPS
Sequence: MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLFWQQPGVYSTAAGYSGGHTPNPTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQAMEKAGDQRVITSEITVALPFYYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: FLIT_SALPB
Sequence: MTSTVEFINRWQRIALLSQSLLELAQRGEWDLLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQLLKGLLQQRLDELSSLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NOP58_SCHPO
Sequence: MFILTETAAGYAIFKAKDKLLKKRDALIEDLKSPEGASNLLKLQSFAKFESTVDALDNVSALVEGKVSSKLSSLLEGLSDSKSSTLVVADPKLGNAINKLPGLEFEIISDSSVQDLYRGIREHLSSLISGLAPSDLNAMSLGLSHSLSRHKLKFSPDKVDTMIVQAIALLDDLDKELNTYAMRVREWYGWHFPEMGKIIQDNLAYARVIKAMGMRTKCSETDFSDILPEEIEATLKSAAEISMGTEITEEDLDNIVMLADQVLELASYRAQLSEYLRNRMQAIAPNLTALVGELVGARLIAHAGSLMNLAKQPASTIQILGAEKALFRALKTKHSTPKYGLIYHASLVGQANSKNKGKIARVLATKAALSLRVDALSDKDTTNGNIGLENRIRVENRLRSLEGGKLLPLPTAPVQQSKVQINGTSAYSTATDAVTKDAEESQEDVEMDIVIEKKKKKSSKLKEADGESSKKEKKEKKDKKHKKSKRKSEESEDGESPKKKKKSKKSKD
What is the function of this protein?
Required for pre-18S rRNA processing.  May bind microtubules (By similarity).
What are the official names of this protein?
Nucleolar protein 58.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GPMI_STAAW
Sequence: MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLDVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAIAHVNSHDSALHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDGRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAYNAIRNFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVNDGDAVIFYNFRPDRAAQLSEIFANRAFEGFKVEQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: NRDR_BACVZ
Sequence: MKCPSCQHNGSRVLDSRPADEGKSIRRRRECEACHYRFTTFEKFEEMPLIVVKKEGVREEFSREKMLRGLIKACEKRPVPLKTLEDMCFDIEKELRNQGVSEVKSELVGEMVMDRLAKIDEVSYVRFASVYRQFKDINVFIDELKDLIKKER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: SIM41_HUMAN
Sequence: MNGSQAGAAAQAAWLSSCCNQSASPPEPPEGPRAVQAVVLGVLSLLVLCGVLFLGGGLLLRAQGLTALLTREQRASREPEPGSASGEDGDDDS
What are the official names of this protein?
Small integral membrane protein 41.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.