PharMolix/UniProtQA huggingface dataset:
Protein: GLMM_CITK8
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDEVEEAIEAEMEKEITCVDSSELGKASRIVDAAGRYIEFCKGTFPNELSLNELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINEEVGATDVRALQARVIAEKADLGIALDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMVRNHMSLHDLCSGMKMFPQILVNVRYAAGSGDPLENDNVKAVTAEVEAALGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RUVB_PROMT
Sequence: MAIVSSITNHSSLPNDKGEERLVGPSLLKEELKLSQQDSLRPKSFDDFVGQSELKKVLEISVKASLKRGEALDHLMLYGPPGLGKTTMALVIAEELGVKARVTSAPALERPRDIVGLLINIQPRELIFVDEIHRLNRISQELLYPAMEDRRLDLTVGKGTSSRMRSIEIPPFTLVGATTKPAALSSPMRDRFGITQRLDFYNYLDLENIIKRSAKLINLVISEEASQQLAKRCRGTPRIANRLIRRVRDYAEVYSHSKKIDVEVVNDALDLHRVDQRGLDATDRSYIGLLVNQYQGGPVGLETLAAGLGEDSTTLETVVEPYLMQIGFLHRTSRGRVVTPAAKKHYLLTSPNNIDK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MDTH_ECOL6
Sequence: MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA
What is the function of this protein?
Confers resistance to norfloxacin and enoxacin.
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_TRIV2
Sequence: MPVVSLAQMMESGVHFGHQTRRWNPKMSPYIYTSRNGVHIIDLVQTAHLMDEAYNYMRSQAEQGKKFLFVGTKRQAAGIIAQEAARCGSHYINQRWLGGMLTNWATIKTRVDRLKDLERREESGALDLLPKKEASMLRRELAKLQKYLGGIKTMRKVPDVVVIVDQRREYNAVQECQKLSIPIVSMLDTNCDPDVVDIPIPANDDAIRSIKLIVGKLADAIYEGRHGQLDVEEEYEDYEGAEDDYEYDETEYTDSVIPDDEEEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PLSX_NOVAD
Sequence: MSLPRIAVDAMGGDEGVRVMVEGAALARRRHDRFKFLLVGDEARIKQALENHPNLRGASEILHAPDIVSGDEKPTQALRRAKTTSMGMAINAVKRGEAGAAVSAGNTGALMAMAKLALRTLPGIDRPALSALLPTLGDNDLVMLDLGANTECDARNLVQFAIMGAAYARIVNGLDAPRVRLLNIGTEETKGTDSLRDAATELKALAGDLALSFDGFTEADKLSRGDVDVVVTDGFSGNIALKSMEGAARFVADLLRRSFSSSLRSKLGFLISRPATELLKHHLDPNNHNGAVFLGLNGIVVKSHGGASALGVANAVAVTARLLEENLTERIKADLARVGAEAIRTSGRSGGKSKSSAAREDGAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: IPKB_MOUSE
Sequence: MGGGTSPEAQQDSVMRTDSSEMTDVESVITSFASSARAGRRNALPDIQSSLATSGSSDLPLKLEALAVKEDAKTKNEEKDQGQPKTPLNEGK
What is the function of this protein?
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
What are the official names of this protein?
cAMP-dependent protein kinase inhibitor beta, PKI-beta, cAMP-dependent protein kinase inhibitor, testis isoform.
What is the protein family that this protein belongs to?
Belongs to the PKI family.
Protein: CLPP1_MYCTU
Sequence: MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins (By similarity).  Degrades anti-sigma-D factor (rsdA) when present in a complex with ClpP2 and ClpX.  Does not seem to act on anti-sigma-L factor (rslA).
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_PSEFS
Sequence: MLVLGLETSCDETGVALYDSERGLLADALFSQIDLHRAYGGVVPELASRDHVKRMLPLIRQVLDEAGCVPTEIDAIAYTAGPGLVGALLVGASCAQALAFAWGIPALGVHHMEGHLLAPMLEKTPPQFPFVALLVSGGHTQLVQVDGIGQYTLLGESLDDAAGEAFDKTAKMMGLNYPGGPEIARLAEKGVAGRYTFPRPMCDRPGLMFSFSGLKTSALNTWQQSVSAGDDSEQARCDIALAFQQAVVETLTIKCKRALKQAGMKRLVIAGGVSANKALRTSLEKMLGDMKGDVFYARPEFCTDNGAMIAYAGCQRLQAGQHESLAISVQARWPMEQLSPL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD209_PANTR
Sequence: MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEESRQDVIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCRRCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNEEGTWQWVDGSPLLPSFNQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
What is the function of this protein?
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates.  May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2.  Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells (By similarity).
What are the official names of this protein?
CD209 antigen, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: AN32A_MOUSE
Sequence: MEMDKRIYLELRNRTPSDVKELVLDNCKSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEEAGEEEGSQKRKREPDDEGEEDD
What is the function of this protein?
Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription.  Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation.  In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex.  Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking.  Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:29467488).  Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R).  Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (By similarity) (PubMed:17557114, PubMed:29467488).
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, LANP, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis.
Protein: SULA_SALG2
Sequence: MYTSGYANRSSSFPTTTHNAALTATENAAAGLVSEVVYHEDQPMMAQLLLLPLLRQLGQQSRWQLWLTPQQKLSREWVQSSGLPLTKVMQISQLAPRHTLESMIRALRTGNYSVVIGWMTEELTEEEHASLVEAAKVGNAVGFIMRPVRAHALSRRQHSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: PDXA_AROAE
Sequence: MASLPILAITSGEPAGIGPELCAQLSRRDWPLRPVVLGDFELIRARAAGAAVVRAYMPDAPAAAGVLDVLHVPLNVAARPGRLDPANAGYVLALLDRAVHGCRSGEFGAIVTAPVHKGVINDAGVAFSGHTEYLAEHTGTPRVVMMLVGGGLRVALATTHLPLAAVPGAITPALLDETLRILHADLAGRFGLAAPRILVAGLNPHAGEGGHMGREEIDVIAPVLERLRGEGMRLVGPLPADTLFVPHTLGQGDAVLAMYHDQGLPVLKHASFGGGVNVTLGLPIIRTSVDHGTALDLAGTGRADPGSLFAAVELATAMVCNRDVAR
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_TROWT
Sequence: MVDISMADVRLLRERLGVGVMDSRNALIEAGGDIERAVEILRLKGLKSAEKREGRSVSEGLVVSRQFATHAVLAELCCETDFVAKSDRFLALSEKVADLVSDADSLETALRVRCDEGSVADLIALEAAVLGENVALRRFARVEGSRFSVYMHRTSSDLPPQVGVILAYEGHDDATARFIAQHIAFAAPEYLSVGDIPQGILQRERDLLTEISRGEGKPEEVLPQIVEGRLVKLYKQNVLLEQDYVRDNKVTISKVLEATGLRVISFARFRVGT
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDOC_PSEPU
Sequence: MMINIQEDKLVSAHDAEEILRFFNCHDSALQQEATTLLTQEAHLLDIQAYRAWLEHCVGSEVQYQVISRELRAASERRYKLNEAMNVYNENFQQLKVRVEHQLDPQNWGNSPKLRFTRFITNVQAAMDVNDKELLHIRSNVILHRARRGNQVDVFYAAREDKWKRGEGGVRKLVQRFVDYPERILQTHNLMVFL
What is the function of this protein?
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.  The beta subunit seems to have a structural role in the holoenzyme.  Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene (PubMed:10692370).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase system, small oxygenase component, Naphthalene 1,2-dioxygenase ISP beta, Naphthalene 1,2-dioxygenase subunit beta, ND subunit beta, NDO subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: RS12_RICPR
Sequence: MPTYNQLVRFGRKSKTRKTKSPALESNPFKSGVCLVVKTVTPKKPNSALRKIATVRLSNKRTVNAYIPGEKHSVKEHDRVLVRGGQVPDLPGVKYHIVLGAYDIAGVKGRKQGRSRYGAHRKQVAATKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PSA3_YEAST
Sequence: MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK
What is the function of this protein?
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus.  It is essential for the regulated turnover of proteins and for the removal of misfolded proteins.  The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  It has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-3, Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteasome component Y13, Proteinase YSCE subunit 13.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MED14_DICDI
Sequence: MDQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPNGMMPMNGEQTTPIIPQNRNISLSLVIHRLVEQSYNSLLGLTEGLPKANDLERKKAIVDYLDGTREKFLRLMVLIKWSEHVPTLTKANNIIDILNLEDSYLREAADLLINTQFSLVNARAPIYDVPTAIDVLTTGTYQRMPTNIKRVIPPPPLKPTQIESALERLNDIIKYKLFISDVPKEFQPITVSDGKAHIFVDDEYEAYLTIDGGSEKSNWVILSLNLFVYSKRNLNGEGPIKVAYDNKMKYVLDRVQNRIISSAQPLFELHNIVHYLCISSQMDILASQVENLKKTILKNNIRCVFGKDQSITVFYWLPEDFNLVGVTQHTLGNLMPNKHTNFKIYIDEHQKIKISHYPPITHPKNENYFKIASLNLETILLQAIELNAYDKVYLLNSLLLDNRITANTTSSSSSSSSNNNNTASPIINRNNNNGKPNLLSTKQSNNPLSRSFHLNDIKLIMSSRFSDENQNDSNGNNDHLPTVLRVMLYGSKFLDITVNFQNGKFSLIKSSNYIEFTNHLEQRLNKDPNEIESIVNVFKLKSLLTCFEEASLFLGLECFNKIPLQMNSSNNSESNQLANELFSDSNFICVSISLAKENNPYYLVISIKATCFTPSFHLLFCKMLPKSTIMTLDSIIKLESDQLNKLLKECPIGSISSSNNTNSNGNGPFQSYISTLLEKIVEASNQKINLLSIQSFLKKENINYYQPSQQDIENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNNGYKNNGITTTTSIVFLFNEQQIQKISPFLSNHISHQTPITISFKNGFYTLSFTQQRPFEYKKYGSGSNININSFGENNSNENYIYRKGNWIFKYQQTSDWFNSFCNDLMTISKITNISSQLLKQMETLEIYKQLITHLTIKPMSIEFVCFVGSNQTRTNVIMFVEKKTAEIKLSFQPYSNPLLVYLEKDINQSPTNDITNSLRAIINSNDISVYINSLISPLELSFYLPLEILVIPRSICQIRLLYKNLYGIDIKLISHEYCAISDSFYSLNSSKQVRLTSINQLHSFMEQRVSLQALDNPTGHRTSWLLPIKQFQKTISRIFIYLNSLNTLKFAQNLMKPNFQPLVPSNPSSQKFSNDYFIVSFSIRDYTSFDIDVTNKNLENSVPSNEELALFCQYFKKKVQQLNYRSQTIGSCIQMLTLPPKILWEFIRVLLEITGPKFDGYTIEISLNTSSIHSKNKESFFHIPDENQVYFILRYLNSSRTDIIPPDQFTDIPIIYNYNEKSIRYWNKLDSNSTSSSSSSTLPKKSLSIVEEVKQKFVEEVAKLIPDALNASSGKSSPISIFFKSFLPKIKPIFSNPTASTLLLIQQQQQQQQQQQQQQQQQQQQQQIENNNFASASSSIR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 14, Putative mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDK_DESRM
Sequence: MERTYLMVKPDGVQRGLIGQIISKFEQKGYKIVGLKMMQISREVAERHYGEHAGKPFFNGLVDFITSGPVVAMVIEGKDVVTTAREMMGATNPLKAAPGTIRATFGVDVGRNIIHGSDSLESAQREIGIFFKSEELIDYDRAIDTWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCT2_ARATH
Sequence: MAHTSESVNPRDVCIVGVARTPMGGFLGSLSSLPATKLGSLAIAAALKRANVDPALVQEVVFGNVLSANLGQAPARQAALGAGIPNSVICTTVNKVCASGMKAVMIAAQSIQLGINDVVVAGGMESMSNTPKYLAEARKGSRFGHDSLVDGMLKDGLWDVYNDCGMGSCAELCAEKFQITREQQDDYAVQSFERGIAAQEAGAFTWEIVPVEVSGGRGRPSTIVDKDEGLGKFDAAKLRKLRPSFKENGGTVTAGNASSISDGAAALVLVSGEKALQLGLLVLAKIKGYGDAAQEPEFFTTAPALAIPKAIAHAGLESSQVDYYEINEAFAVVALANQKLLGIAPEKVNVNGGAVSLGHPLGCSGARILITLLGILKKRNGKYGVGGVCNGGGGASALVLELL
What is the function of this protein?
Catalyzes the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA (PubMed:22332816).  Generates the bulk of the acetoacetyl-CoA precursor required for the cytosol-localized, mevalonate-derived isoprenoid biosynthesis (PubMed:22332816).  The generated isoprenoids are required for normal growth and development (PubMed:22332816).  Essential protein during embryogenesis (PubMed:15266054).
What are the official names of this protein?
Acetyl-CoA acetyltransferase 2, Acetoacetyl-CoA thiolase 2, Thiolase 2, Protein EMBRYO DEFECTIVE 1276.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
Protein: MEND_HAES1
Sequence: MSASVFNRCWSKVILETLSRQGVSHFCIAPGSRSTPLTLEAIRLQENGRGTCHAHFDERSLGFFALGIAKASKKPVAVIVTSGTATANLYPAIIEARQTDVPLIILTADRPPELLECGANQAILQQNMFAQYPIASINLPRPSQNYSAQWLISVLDQACFRQKQGGVIHINVPFAEPLYNANNDEIDLHPWLSNIQSWLTQNKNWIQHQEQHTEVITHKYWDQWRTKKGIIIVGRLPSEQAMGIAEWADNMGWIMITDIQSHVKPTLPYADIWLANQTVRKKLLQAEIVIQFGSGFIGKRINQFLAEFKGEYWIIENNQKAVDPYHHAHTRFNAKPHHWLRAHPPMRKKPWLLEPLALAKFCADFIKQRVGSNLNEASLAHNIELLLPKSNSVLFLGNSLFVRLADALSQPSANYPIYTNRGASGIDGLLATAAGIAVGSEQTLVAMIGDTSTLYDLNSFALFKQLNQPAIIFVINNNGGAIFDMLPVDIAVKEKYYRMSHYLEFSHIAAMFDLKYARPYTWADLATVLKQAYSRRETTVIEIKVNPNDGSNIYKDLIDKIGHALIGV
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SYP_PSEMY
Sequence: MRTSQFLLSTLKETPSDAVVISHQLMLRAGMIRKLASGLYTWLPMGLRVLRKVENVVREEMNAAGALEVLMPAIQPAELWQESGRWVQYGPELLRVKDRHEREFCVGPTHEEVITDLARNELNSYKQLPINMYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHADQASLQETYDRMHQAYCNVFSRLGLNFRPVQADTGSIGGTGSHEFHVLAESGEDDIAFSNVSDYAANIEKAEAVPREKERAAATEDMRLVDTPNTKTIDALVQGFGLAIEKTIKTLVVHAAEEGKLIALIVRGDHELNEIKAANLEQVASPLQMASEAEIRAAIGAGPGSLGPVNLPIPCIVDRSVALMSDFASGANIEDKHYFGVNWERDLPLPTVADLRNVVAGDPSPDGQGTLEIKRGIEVGHIFQLGTKYSEAMNCQVLGENGKPVTLTMGCYGIGVSRVVAAAIEQNHDERGILWNDALAPFHIALVPLRYETEQVREATDKLYAELTAAGYEVLLDDRDKKTSPGIKFADMELIGIPHRVVVSDRGLAEGNLEYKSRAETEAQAVPLAEILPFLQARISR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1A3_METAC
Sequence: MIRKRQSGSNKSVSSGNNQEVTRVRTPRKDRNEVLATVASLLGSKRVTLQCMDGVVRMGRIPGSKNKKMWVREGDVVIANPWEIQDSKADVIWKYTKPQVDWLERKGYLN
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
What are the official names of this protein?
Translation initiation factor 1A 3, aIF-1A 3.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.