PharMolix/UniProtQA huggingface dataset:
Protein: CBIT_METAC
Sequence: MSEIVSVSGGPTKPEIIAVSLSKLGLQDGDRFADVGCGTGSVSIEAARIARNLTIYAIDARKEALLATEANFKSFGIENARVLAGEASELLGSGGSIDSIDCAFVGGTKNIDAILEKLVEKKTRSIVVNAVRIETVVRTIEAMKKLGIFDEVVHISVSRSAPIAGETMFKPENPVYIVVGKKQA
What is the function of this protein?
Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
What are the official names of this protein?
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating).
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
Protein: DHE3_THEPR
Sequence: MVEIDPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKVFTGFRVQHNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGGGKGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIMGWMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREAAKALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNPDGLDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITEKNADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYFEWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVAVSRVYQAMKDRGWVKK
What are the official names of this protein?
Glutamate dehydrogenase, GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: GRPE_BRUC2
Sequence: MADEKNKPENPDLDQRDINNPRDREALKQAADDFLKARRAEARAEAAADEAEGEVDETANRIAVLEADNTELKDQMLRVAAEMENLRKRTQRDVQDARAYAITNFARDMLSVSDNLRRALDAIPADALEADSNLKSLSEGVEMTERAMLLALERHGVKKLEPEGQKFDPNFHQAMFEVPNPDLPNNTVVQVVQAGYAIGDRVLRPAMVGVSKGGPKVSAENGASTSEDNA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH1_HYDCU
Sequence: MPNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQPHSRIVLLKTFNSDGFIFYTHYDSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRETSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAMSLPDRNLTCPAHWGGYQLKPCYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, PNP/PMP oxidase 1, PNPOx 1, Pyridoxal 5'-phosphate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: GHRB_ECO27
Sequence: MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLLGSNENVDAALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRYGMAACAVDNLIDALQGKVEKNCVNPHVAD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IN80E_HUMAN
Sequence: MNGPADGEVDYKKKYRNLKRKLKFLIYEHECFQEELRKAQRKLLKVSRDKSFLLDRLLQYENVDEDSSDSDATASSDNSETEGTPKLSDTPAPKRKRSPPLGGAPSPSSLSLPPSTGFPLQASGVPSPYLSSLASSRYPPFPSDYLALQLPEPSPLRPKREKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGTTLTPLPPPKMPPPTILSTVPRQMFSDAGSGDDALDGDDDLVIDIPE
What is the function of this protein?
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
What are the official names of this protein?
INO80 complex subunit E, Coiled-coil domain-containing protein 95.
What are the subcellular locations of this protein?
Nucleus.
Protein: LUXS_VIBAL
Sequence: MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTAPNKDILSEKGIHTLEHLYAGFMRNHLNGDSVEIIDISPMGCRTGFYMSLIGTPSEQQVADAWIAAMEDVLKVESQNKIPELNEYQCGTAAMHSLKEAQQIAKNILDAGVSVNKNDELALPESMLKELRID
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: EFTU_LACGA
Sequence: MAEKEHYERTKPHVNIGTIGHVDHGKTTLTAAITTVLAEDGLAQAEDYSQIDAAPEEKERGITINTAHVEYETKNRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVKYIVVFLNKVDLVDDPELIDLVEMEVRDLLTEYDYPGDDVPVIRGSALKALQGDPEQQDVIRKLMETVDEYIPTPERDTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLTDKVEKSTVTGLEMFHKTLDLGEAGDNVGVLLRGIDRDQVERGQVLAAPGSIQTHKKFKGQVYILNKDEGGRHTPFFSDYRPQFYFHTTDVTGKIELPEGTEMVMPGDNVEFTVELIKPVAIEKGTKFTIREGGKTVGAGQVTEILD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASQC_EMENI
Sequence: MRPAILAAFSTLPAAAKATYPFAPETFDGSYKDIGLPTIYDLSATQSTNYNGSWATGSWITSVSGGQYFVVSHYVNDGIHDVYRSSILDLSSLKYRYFFQAGNGSYTASPPSHLKAGVGKGNGFEGISNDNYTTMRVQSSHPNVTFDLTYHATTKPLINGGAGVVMLGASESKQWSLPACWTNGFLIVGDEQIPIDPKRSLTWYDRQWGTGGLTNWTWYGLHIPKTGHVLSIWTGDTDADRAAPITPVRFATVRNAYGAQTVCNITWIPDLSHIFHSDSTNKSYPLAWTVEIPSYDAIIKVKSRTENQLNTGSHGSEPEAYNGFVTFAGQFQGTETEGFGIVEIVYL
What is the function of this protein?
Dehydratase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934, PubMed:28114276).  Within the pathway, the dehydratase asqC catalyzes the dehydratation of the epoxide at C-3 to produce (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B (PubMed:28114276).  The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin.  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Dehydratase asqC, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqC, Aspoquinolone biosynthesis protein C.
Protein: OBG_ACIBT
Sequence: MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSIYIQADDDTSTLVDYRYTRKFRAERGKNGAGANCTGRGGEDVVLKVPVGTTIVDTDSGDIIGDLVEDGQRVMVASGGEGGLGNTHFKSSTNRAPRKCTTGTKGEFREIRLELKVLADVGLLGMPNAGKSTFIRAVSAAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRILLHIIDVQPIDGSDPAHNAKAIMNELAKFSPTLAKLPIVLVLNKLDQIAEESREEWCQHILDELQWTGPVFKTSGLLEEGTKEVVYYLMDQIEQQREREVEDPEYAAEVRAFREQLEAETREQTIAAKEAYRAMRKAQRLESMMDDDDDFDDDEDDGDVESIYVRD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNF19_BOVIN
Sequence: MAVMPLKVWHQEVVTFEDVAVYFTRTEWAGLSPAQRALYRSVMLEIYRSLTSLGYPVPKPALISLLERGDLPVGLETQDNPPAQGTRDIYKNSRTHMDSELTPTWGISEERDLMMSHGPQKNVLNKSSFLETCELEQHQEIPTVKNIRGKVLRIHYDRKPFRCEECGKCFSYFSYYVRHQRIHTGEKPFECNECGKAFNGNSSLIRHQRIHTGEKPYQCEECGRAFNDNANLIRHQRIHSGDRPYLCRECGNGFTSSSEFIIHQRIHTGEKPYECNECGKAFVGNSPLLRHQKIHTGEKPYECNECGKSFGRTSHLSQHQRIHTGEKPYSCTICGQAFNFHTKLTRHQRVHSEVKPFDCICCGKVFSTQAQLKRHLRIHIQETSCDECGKVFTSKRNLLQHQRVHTRKKPREYVKYEKTFRTSSQLDCAHPGEKPVLDVGCFGLPEFFTPFYW
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 19.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATA_ANAD2
Sequence: MSGTLMRMAGPTVVAEGLSGASLNEVVRVGEERLLGEIIRIEGDRATIQVYEETAGLALGEPVEASGEPLAVELGPGLLGSVFDGVQRPLSELAAREGDFLGRGASLPALDRTRAWEFEPAVAPGDRVEGGARLGVARAPGAPDHPVVVPPGVTGRVAEVRGGARRVDEPAVLLEGGATLALLERWPVRRPRPARRRLPPDVPFLTGQRVLDCFFPVSAGGTAVVPGGFGTGKTVLEQSLAKWAAADVVVYVGCGERGNEMSEVLDEFPRLEDPRTGGPLLARTVMIVNTSNMPVAAREASIYTGCAIAEYFRDMGRSVALMIDSTSRWAEALREISARLEEMPGEEGYPTYLASRLARFYERAGRVETLGGAEGAVTMVGAVSPPGGDLSEPVTQCSLRATGALWALSADLAHRRHYPAVDWSVSFTLEGDRLAGWFEREAGDGFGALRDEARKLLQRERELAEVAELVGTESLQDAERLVLESARLLREGFLRQSALDPADATCPPAKAFEMLRLFLEWHRRAGAAVGAGVPLRSILDTGLGARLLRLAQLPAAEVPGAAAALRADLSEALARLEAE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: TRI50_PIG
Sequence: MAWQVSVPELEDRLQCPVCLEVFKEPLMLQCGHSYCKGCLLSLSRHLDSELRCPVCRQEVDSSSSPPNVSLARVIEALQLPGDPEPQVCTHHRNPLSLFCEKDQELICGLCGLLGSHQHHRVTPVSTVYSRMKEELAALISDLKQEQKKVEEQVAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGVEGHTRGLVASLDMQLEQARGAQERLAQATCMLEQFGNESHYEFIRYHSTASSAELQQARLLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPESLKLDPTTAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFSCPRVPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRLLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPLPSGPGHLTPSQPTKL
What is the function of this protein?
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1.  In turn, promotes starvation-induced autophagy activation.  Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.  Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM50, RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins.
Protein: PYRDB_GEOUR
Sequence: MGKPDLSVEVAGIKLRNPVMTASGTFGYGKEFADYLDLEKIGAIITKGLSIRPKAGNPTPRIVETPGGMLNAIGLQNVGIDAFIQEKLPFLRTVNTPVIVNLYGNTLEEYGELAEKLDKLPEVAGLEVNISCPNVKQGGIVFGTDPNAAYEVVSLVRESTIKPLIVKLSPNVTNVVEMANACVDAGADALSLINTLTGMAIDLQKRRPILANMTGGLSGPAIKPVALRMVWQVAQAVKVPVIGIGGIMTATDALEFMLAGATAVQVGTANFLDPSAAQTIAEGMETYLEENGIADVKELIGALIT
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLIP_RAT
Sequence: MTSCVLAGSIETTPKVSPGDSEAKPLIFTFVPTLRRLPTHIQLADTSKFLVKIPEEPTDKNPETVNRFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQLTSPTTSEQLAHKPPAFSFVSPTNQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVELCFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQDMAIPHKPVSLHPLYQSKLYPPAKSLLRPQTLSHADCLTPGPFSHLSSFSLRDEQEKSPTLLSQDTYNKPGHPMVTIPEHDTLDSKE
What is the function of this protein?
Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity).  Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1.  Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (PubMed:22343712, PubMed:26436652).  Binds chromatin (By similarity).  May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity).  May also repress MYOCD transcriptional activity (By similarity).
What are the official names of this protein?
Muscular LMNA-interacting protein, Cardiac Isl1-interacting protein, CIP.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: GLYM_KLULA
Sequence: MLSRSARCSRAVLFSAKRSLASQANTGANASANQVMVSKHVQDIDPEMYDILTKERKRQKHSITLIPSENFTSKSVMDLLGSEMQNKYSEGYPGERYYGGNQFIDMAESLCQKRALELYNLDPQLWGVNVQPLSGAPANLYAYSAVMETNDRLMGLDLPHGGHLSHGYQLPSGTKISYISKYFQTMPYHVDSQTGIIDYDFLSKTSKLFRPKVIVAGASAYSRVLDYKRFKEIADACGAYLMSDMAHISGLVAAGVTRSPFEYSDIVTTTTHKSLRGPRGAMIFYRKGVRKVTKKGKEVLYDLDKRINFSVFPGHQGGPHNHTISALAVALKQAATPEFKEYQAAVVENARIFGEELVKKGFELVSGGTDTHLILINLSNLGIDGARLETLLENINIAANKNTIPGDKSALFPSGLRVGTPAMTTRGFGPQEFAQVAAYIDRAVKLAIGIKSQESPDAKDARSKLASFKELCKESDQVKQLADEVYQWVGEFPVPGEL
What is the function of this protein?
Interconversion of serine and glycine.
What are the official names of this protein?
Serine hydroxymethyltransferase, mitochondrial, SHMT, Glycine hydroxymethyltransferase, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSA1_PONAB
Sequence: MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIHDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: BAMD_XYLFT
Sequence: MIQRPTFFSPIHLLAVLLATFILITGCHRETKKNADDGMPVEHLYDKAHTLMKKGNWAGAELSFKRLIAQYPYGPYTEQAMVENAYAQYKSGKHDDAVSSIDRFIRTYPTHHNIPYMYYLRGLSNSNRDTIFLRKVWSLDLSRRDLSAPQQAYNDFKTVLDRYPNSRYATDAKKQMTELRNMFAQYEMNVTLYYLRRTAWVAAAGRANFLLETYPQSPFQYDAVAALGEAYTHLGNKTLADNARQVLQTNAPDHPWLKGKKWPKYPAAIRKLNPFAGEKSAATGQTNAVVNSN
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamD.
What is the protein family that this protein belongs to?
Belongs to the BamD family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: MURE_BUCAP
Sequence: MKKNNLKYILFPWIKNTPQKKFSNLSLDSRKLTSKDVFIAIKGTKKDGNDFIFEAVKKRVVAILSETKEKKKHGEINYINNIPILSFFKLSEKISNLAARVYKEPAKTLKIIGVTGTNGKTTVTQLINQWSELLGKKIATMGTLGNGFYNALKTTKNTTSSAIDIQSFLHIAAKKKINLVTMEVSSHGLVQNRVKNIPFYIGIFTNLTQDHLDYHKNMKQYESAKWSFFSQHKIKKIILNANDKYAKKWLRKLSDKYTIAVTIQNEKQKKYSTKWINATGIKYNVNSTDVEFESSWGQGILSTCLIGYFNIQNLLLSFASMLEMNYKLSDLINTSIQLQPILGRMQKFDVFGKPKVIIDYAHTPDALKKALNAIKSYYKKKIWCIFGCGGERDQTKRPLMGSISEKIADRVIITNDNPRNENQNKIIKEIVQGCIKKEKIIIIPNREKAISSTFFKANIDDIIFISGKGHENQQIIKNKIINYSDQKVVIKLLEKKI
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_METMA
Sequence: MLDESYESRIIDGKVLAQQVEEEVRSGVEDLESNRGITPGLATILVGDDPASKMYVRLKHRACERVGIRAEDFLLPADSTQEELLALIDSLNNNKDVHGILLQLPLPEHFSPQEAMEAISPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNAVIVGHSNVVGKPMAAMLLNRNASVSVCHIFTDDLKKYTLGADILVVAAGVKHLIKADMVKEGAVIFDVGITKEEDGVYGDVDFENVIKKASLITPVPGGVGPLTVAMLMKHVLMCAEKSL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TSAD_RICPU
Sequence: MIKILGIESSCDDTAVSIITENREILSNIIISQNTEHAVFGGVVPEIAARSHLSHLDKALKNVLKESNTKLTDISTIAATSGPGLIGGVIVGSMFARSLSSALKKPFIAINHLEGHALTARLTDNIPYPYLLLLASGGHCQFVAVLGLGKYKILGSTIDDAVGEAFDKVAKMLNLAFPGGPEIEKRAKLGDPHKYKFPKPIINSGNCNMSFSGLKTAVRTLIINLKEINDTVINDIAASFQFTIGEILSSKVQDAIRAYEQITNNFDKKNIVIAGGVAANKYLQKILSSCAKTYGYRLIYPPIHLCTDNAAMIAYAGLERYNNKLFTPLNFCPKARWSLEDISN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RODZ_ECO81
Sequence: MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELNNNQSQSVPLDTSTTTDQAMATTPTSPVDTTATNTQTPAVTAPAPAVDPQQNAVVPPSQANVDTAATPAPAATTTPDSAAPLPTDQAGVTTPAVDPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.