PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_PSEU2
Sequence: MTDTVQTLIPTLDVSERVARPKVEAGVKLRGAEKVARIPVKIIPTVDLPKKPDWIRVRIPVSPEVDRIKQLLRKHKLHSVCEEASCPNLGECFSGGTATFMIMGDICTRRCPFCDVGHGRPKPLDVNEPKSLAIAIADLRLKYVVITSVDRDDLRDGGAQHFADCIREIRLLSPGVQLETLVPDYRGRMDVALEITAAEPPDVFNHNLETVPRLYKAARPGSDYQWSLTLLQRFKQMVPHVPTKSGLMLGLGETDEEVIEVMQRMREHDIDMLTLGQYLQPSRNHLPVQRFVHPDTFAWFAEEGYKMGFKNVASGPLVRSSYHADEQAKIAKAML
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_SALPA
Sequence: MYTKIIGTGSYLPEQVRTNADLEKMVETSDEWIVTRTGIRERHIAAPDETVATMGFTAANRAIEMAGIDKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSIADQYVKSGAVKHALVVGSDVLARTCDPGDRGTIIIFGDGAGAAVLSASEEPGIISTHLHADGRYGELLTLPNADRVNPDNPIYLTMAGNEVFKVAVTELAHIVDETLAANNLDRSELDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKAGQLVLLEAFGGGFTWGSALIRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANDJ_EMEVA
Sequence: MAPAIQANSNGTMNVNGKCRDGHTAEQRNVMDDALPIEITVEERGKAFAKDPWAHEYSVSEQALRDQERLIDQYHHKVLIVGAGHGGLLFAVRLLQTGNFGINDILIVDEAAGFGGTWYWNRYPGLMCDTESYIYMPLLEETGYMPREKYASGPELRANAERISHLWGLKRRALFRTAIKALDWNDAQGQWKATAQGLGKLQQVKLSADFAIIATGLYASPRIPDFPGLWNYKGPVFHPARWDYSVTGGTPERPEMTRLHNKRVAIVGTGASAVQIVPQLARHSKHLMVFQRTPSGVDQRDNCYTDKARWKEIASTKGWQRQRMENFNAFIGDPKSAPAVNMVGDRWTSMPSYSMTIGANGITKPGYQDEMREMDSIRQGKIRSRVHAIVHNPARADILSPNYPGWCKRPCFHDDYLAAFNEPNVDLVDLQGKGSISFTATGLAVADTQYEADVVIVSTGYTSPKDRSSPGSRANIAITGRGGLEMERKWESGLSTLHGVMTRDFPNLFFPGPAQSGVCTNQTYTLDQLARHVAYIMARGIQQCNGQAMVVEPSEEAERAWADQVVQRAGDSLTAFAACTSTSLFSAAKMTKDQIMNAARLTTWREGIASYVIELEAWRSEGTLQGLEIKRLA
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of anditomin, a fungal meroterpenoid (PubMed:25216349).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase andM (PubMed:25216349).  DMOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by the cytochrome P450 monooxygenase andK, which is further prenylated by the prenyltransferase andD to yield farnesyl-DHDMP (PubMed:25216349).  Further epoxidation by the FAD-dependent monooxygenase andE leads to epoxyfarnesyl-DHDMP (PubMed:25216349).  The next step involves the terpene cyclase andB that converts epoxyfarnesyl-DHDMP into preandiloid A through opening of the epoxide ring followed by the cyclization of the farnesyl moiety (PubMed:25216349).  Preandiloid A is in turn oxidized at the C-3 hydroxyl group to yield preandiloid B by the dehydrogenase andC (PubMed:25216349).  The dioxygenase andA is solely responsible for the dehydrogenation of preandiloid B leading to the enone preandiloid C, as well as for the intriguing structural rearrangement to generate the bicyclo[2. 2. 2]octane core, transforming preandiloid C into andiconin (PubMed:25216349).  FAD-binding monooxygenase andJ then produces andilesin D which is reduced by dehydrogenase andI to yield andilesin A (PubMed:25216349).  Action of acetyltransferase andG followed by a spontaneous acetate elimination leads then to andilesin B, which is in turn substrate of the short chain dehydrogenase andH to yield andilesin C (PubMed:25216349).  Finally, the dioxygenase andF catalyzes the transformation of andilesin C to anditomin (PubMed:25216349).
What are the official names of this protein?
FAD-binding monooxygenase andJ, Anditomin synthesis protein J.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: TI110_PEA
Sequence: MNPSTLKPSHTHPSLLLPAPSPLRTQRRRFRVSLPRCSSDTNNPASSSSPPQRPPKELNGIEILVDKLSSPARLATSAVIVAGAVAAGYGLGSRFGGSRNAALGGAVALGAAGGAAAYALNAAAPQVAAVNLHNYVAGFDDPSILTREDIEVIANKYGVSKQDEAFKAEICDIYSEFVSSVIPPGGEELKGDEVDKIVNFKSSLGLDDPDAAAVHMEIGRKLFRQRLEVGDREGGVEQRRAFQKLIYVSNIVFGDASSFLLPWKRVFKVTESQVEVAIRDNAQRLYASKLKSVGRDFDLGKLVTLKETQSLCCLSDELAENLFREHARKLVEENISVALGILKSRTRAVPGVSQVVEEIEKVLAFNDLLISFKNHSDIDRLARGVGPVSLVGGEYDADRKIEDLKLLYRAYVSDALSSGRMEDNKFAALNQLKNIFGLGKREAEAILLDITRKVYRKRLGQTVSSGELEMADSKAAFLQNLCDELHFDPQKASELHEEIYRQKLQQCVADGELTDENVAALLKLRVMLCVPQQTVEAAHAEICGNLFEKIVKDAIASGVDGYDDETKKSVRKAAHGLRLTKETALSIASKAVRKMFITYVKRSRSAKGNGESAKELKKLIAFNTLVVTKLVEDIKGESPDVKIEEPKIEEPEEIRESEEYEMRITSDTQENKTGQRACRKDGKAWSDRITLKDDLPEKDRADLYKTFLTYCLTGDVVRIPFGVEIKKKKDDTEYIYLNQLGGILGLTGKVIMDVHRGLAEQAFRKQAEVLLADGQLTKARVEQLGKMQKEIGLSQEYAQKIIKNITTTKMAAAIETAVTQGKLNMKQIRELKESNVDLDSMVSVSLRETIFKKTVGDIFSSGTGEFDEEEVYEKIPLDLNINKEKARGVVCELAQNRLSNSLIQAVALLRQRNHKGVVFSLNNLLACDKAVPSQTLSWEVSEELSDLYTIYLKSDPSPEKLSRLQYLLGINDSTAAALRDSEDSLLETAEEEKFVF
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  Forms a voltage-dependent cation-selective channel at the inner envelope of chloroplasts, which specifically responds to a transit peptide.  Calcium acts as an effector of gating and selectivity.
What are the official names of this protein?
Protein TIC110, chloroplastic, Chloroplast inner envelope protein, 110 kDa, psIEP110, IAP100, Translocon at the inner envelope membrane of chloroplasts 110.
What is the protein family that this protein belongs to?
Belongs to the chloroplast envelope anion channel-forming Tic110 (TC 1.A.18) family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: RL17_PARMW
Sequence: MRHQCRVPQLGRPADQRKAMLRALTTQLIREGRVTTTKARAKALRDEAERMITLAKDGSLASRRRALGYIYDKQLVHALFDKAPDRYSDRKGGYTRITRTVPRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL6_CYAP4
Sequence: MSRIGKRPIPIPDKVAVTIDGSTVKVKGPKGELSQVLPPEVVVVQENSSLLVNRRDDSRPARQRHGLSRTLVANMVKGVTEGFRKNMQIVGVGYRLQVTGNKLAITAGYSHPVEIDLPKGISVEVDQKAVPIANSKSQQGFNFGVIGIDKQAVGDVAALIRAVRPLEPYKGKGIRYATETLRLKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y633_STRA5
Sequence: MLHKNDIIETEISDISHEGMGIAKVDGFVFFVENALPGEIIKMRVLKLRKRIGYGKVEEYLTTSPHRNEGLDYTYLRTGIADLGHLTYEQQLLFKQKQVADNLYKIAHISDVLVEPTLGMTIPLAYRNKAQVPVRRVDGQLETGFFRKNSHTLVSIEDYLIQEKEIDALINFTRDLLRKFDVKPYDEEQQSGLIRNLVVRRGHYTGQLMLVLVTTRPKIFRIDQMIEKLVSAFPSVVSIMQNINDRNSNVIFGKEFRTLYGSDTIEDQMLGNTYAISAQSFYQVNTEMAEKLYQKAIDFSDLNSEDIVIDAYSGIGTIGLSVAKQVKHVYGVEVVEKAVSDAKENATRNGITNSTYVADSAENAMAKWLKEGIKPTVIMVDPPRKGLTESFVYSAAQTKADKITYISCNSATMARDIKLFEELGYHLVKIQPVDLFPMTHHVECVALLVKA
What are the official names of this protein?
Uncharacterized RNA methyltransferase SAG0633.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: STB1_YEAST
Sequence: MSQPQMSPEKEQELASKILHRAELAQMTRQLKLGLSNVPSTKRKQDSTTKKRSGEDAEDVDEDHKTLLEAISPAKKPLHDDTNKMTVISPVKFVEKPNTPPSSRQRKAEDRSQQIKPRKEDTPSTPRASATPIILPHASSHYQRPHDKNFMTPKRNNNNSSNHSNNNNNIKKKAAGSKDAPQDSDNTAGADLLMYLATSPYNKSSHHGTPMAVRMPTTPRSYHYASQLSLNGNTASTSNDAVRFSHIKPSASSPQSTFKSNLLPNFPDESLMDSPSLYLSNNNGSVQATLSPQQRRKPTTNTLHPPSNVPTTPSRELNGTNFNLLRTPNFNMGDYLHNLFSPSPRVPAQQGASNTSASIPSVPAMVPGSSSNTSAIATAAISSHTTNNFLDMNANGIPLIVGPGTDRIGEGESIDDKLTD
What is the function of this protein?
Involved in the regulation and timing of MBF-dependent transcription in late G1 of the cell cycle.
What are the official names of this protein?
Protein STB1, SIN3-binding protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AT392_HYAAE
Sequence: MVKCTPLLALTVIVSAGSDALSDPTVKRLAKLATINQAPATQSNSDSKRVLRASDVPNEVAAGESRSPKSLWPWEVEDKLAPLKEKLISTSADDLEAGGSAKKNALPMTWRWLWQNQIETKKTPIDEISKEVQTAMDLISSKATHEELNKAGVSVSDYVKALKLTLPEVDVDVVNRGMEYNIHLGNK
What is the function of this protein?
Secreted effector that acts as an elicitor of hypersensitive response (HR) specifically on plants carrying defense protein RPP39 (PubMed:22359513).  The allele ATR39-1 is recognized by RPP39, whereas the ATR39-2 allele is nor recognized (PubMed:22359513).
What are the official names of this protein?
Avirulence protein ATR39-2, Arabidopsis thaliana recognized protein 39-2.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell.
Protein: O1537_MOUSE
Sequence: MEDMAAGNHCTVTEFFLAGLSEKPELQLPLFLLFTGIYLITMAGNLGMITLIGLSSHLHTPMYYFLSSLSFIDFCQSTVVIPKMLVSFLTEMNIISYSECMAQLYFFLTFGIAECYTLAAMAYDRYVAICNPLLYNVTMSYQIYSSLISGVYIFAVICSSFNTGFMLRTQFCNLDVINHYFCDLLPLLNLASSNTYINEILILFFATLNSFVPVLTIITSYIFIIVTILSIHSREGKFKAFSTCSTHISAVAIFYGSGAFTYLQPSSLNSMGQAKVSSVFYTTVVPMLNPLIYSLRNKDVSIALKKILERKKFM
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1537, Odorant receptor K4, Olfactory receptor 144, Olfactory receptor 7B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HOX14_ORYSJ
Sequence: MDRYGEKQQQQQMFASYVDASLLAASGEVQGERPRARRRRRRGARCVGGGGGGGEVDGGDPKKRRLSDEQVEMLELSFREERKLETGRKVHLASELGLDPKQVAVWFQNRRARHKSKLLEEEFSKLKHAHDAAILHKCHLENEVLRLKERLVVAEEEVRRLRSAAGSHTASGEGGDIMGLGGSGACVAGSPSSSFSTGTCQPPSFGGGDHLGDDDLVYVPEYGGYADNSVVEWFSLYGLI
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein HOX14, HD-ZIP protein HOX14, Homeodomain transcription factor HOX14, OsHox14.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPS_YERPE
Sequence: MGKNNDWLNFEHLVKDKQIEALQPPSMYKVILNNDDYTPMEFVIDVLQKFFSYDIERATQLMLNVHYQGKAICGVFTAEVAETKVAHVNQYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: PTER_BOVIN
Sequence: MSSLSGKVQTVLGLVEPGTLGRTLTHEHLTMTFDCCYYPPPPSHEAISKEPIIMKNLFWIQKNPYSHKENLQLNQETEAIKEELLDFKAKGGGALVENTTTGLSRDVRTLKWLAEETGVHIIAGAGFYVDATHSSETRAKSVEQLTDVLVNEILCGADGTSIKCGVIGEIGCSWPLTDSERKVLQATAHAQTQLGCPVIIHPGRNQSAPFQIIRVLQEAGGDISKTVMSHIDRTILDKKELLEFAQFGCYLEYDLFGTELFHYQFNPDIDMPNDNKRIKRVRLLVDEGYEDRILMAHDIHTKNRLTKYGGHGYSHILTNIVPKMLLRGITEGALDKILIENPKQWLTFK
What are the official names of this protein?
Phosphotriesterase-related protein, Parathion hydrolase-related protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
Protein: PHSM_STRPN
Sequence: MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTGKKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGLGRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSRSYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARNLTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDTHPSMVIPELIRLLTARGIDLDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHLVPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSELKAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYEDKAVVKEKLESIKAHNKRKLARHLKEHQGVEINPNSIFDIQIKRLHEYKRQQMNALYVIHKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVVMVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGEENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERLERFYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRTIAQYNEDIWHLN
What is the function of this protein?
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism.  Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates.  However, all known phosphorylases share catalytic and structural properties.
What are the official names of this protein?
Maltodextrin phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
Protein: SYP_STRR6
Sequence: MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLPLANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKSDFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDAYSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSARTDLDRWVVLDKSVVSFDEIPVEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATNEYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVGNDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVRNAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFKLGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRYAWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKFSDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA_SHEDO
Sequence: MNIIHQVNEAKVTSNKPLPALLSASLLTCIREERILFDRLSFDINPGDIVQIEGPNGAGKTSLIRILAGLSRPYSGHVSYCGETILACREEFNADLLYLGHLPGVKSELSAAENVDFNLTLSGYQDFDTQAALAHMSLAGFEDALAGHLSAGQHRKTALARLLHTQCKIWILDEPFTAIDKKGVEQLERLFLAHVDNGGCVILTTHQDMSLIKAEQLRTLTLDYRSL
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CRG2_RANTE
Sequence: YEDRNFQGRCYECSGDCADLHSYFSRCNSIKVDSGCWMLYERPNFLGHQYFLKKGEYPDYQQWMGFSDSVRSCKVIPQQKGPHKMKIYEKEELKGQMLEVLEDCPSVFELFKNHDINSCNVLEGHWIFYEQPNYRGRQYFLKPGEYKRFSDWGSLNARVSSFRRVLDSC
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin 2, Gamma-crystallin II.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: PPIA_HYLLA
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: YSCB_YERE8
Sequence: MQNLLKNLATSLGREPFVADKQGVYRLTIDKHLVMLAPHGSELVLRTPIDAPMLREGNNVNVTLLRSLMQQALAWAKRYPQTLVLDDCGQLVLEARLRLQELDTHGLQEVINKQLALLEYLIPQLTPFSVASRVGWN
What is the function of this protein?
Functions as a specific chaperone for YopN.  It could facilitate the secretion and the subsequent translocation of YopN (By similarity).
What are the official names of this protein?
Chaperone protein YscB, Yop proteins translocation protein B.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Not exported across the inner membrane.
Protein: COBT_MYCBP
Sequence: MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RL20_BUCAT
Sequence: MARIKRGVIAHARHKKILKQAKGYYGARSRIYRVAHQAVIKAGQYAYRDRRQRKRQFRQLWISRINAAVRQSKMSYSNFIFGLKKASINIDRKILSDIAIFDLLSFNALVKKAKEALL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: KGUA_COXBU
Sequence: MNKANLFIISAPSGAGKTSLVRALVKALAEIKISISHTTRPKRPGDQEGVDYFFIDETRFQAMVKEGAFLEHATIYERHYGTEKDWVLRQLKAGRDVLLEIDWQGARQIRELFPPALSIFILPPSIEALRERLIKRRQDDTAIIEQRLALAREEMAHYKEFDYLVVNDNFDQAVQNLIHIISAERLQRDVQEKKLSRLLAELVEKQ
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDRP_RICRO
Sequence: MTKLIIHLVSDSSVQTAKYAANSALAQFTSVKPKLYHWPMIRNLELLNEVLSKIEYKHGIVLYTIADQELRKTLTKFCYELKIPCISVIGKIIKEMSVFSGIEIEKEQNYNYKFDKTYFDTLNAIDYAIRHDDGQMLNELSEADIILIGPSRTSKTPTSVFLAYNGLKAANIPYVYNCPFPDFIEKDIDQLVVGLVINPNRLIEIREARLNLLQINENKSYTDFNIVQKECLEVRKICDQRNWPVIDVSTRSIEETAALIMRIYYNRKNKYNK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: LGT_FRAT1
Sequence: MLQYPHINPVALQLGPIKIHWYGLMYLLGIFAGWYLTRYRAKVKPWAPIKPEQVGDLTFYVALGVILGGRIGYIIFYNLPYYFHNPSQMFFLWDGGMSFHGGFIGVLIAFALFARKIGANFFDLGEFVAPVIPIGLGAGRIGNFINGELWGKVTDSPLGMVFPTGGPLPRYPSQLFEFFFEGVVLFSVLWLVTIKKRPRYLVLGLFMFLYGCARFICEFFRQPDPQYGYIFFNWMTMGQILSIPMILLGAVILIAVFIKIRKNKCKNI
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.