PharMolix/UniProtQA huggingface dataset:
Protein: EPIB_STAEP
Sequence: MDNIFVPSNIYMVRTPIFSIELYNQFLKSDNIDYDLILQNDIFKESIMTTTYNLYQSIGKIDWEKDNKKTRNVKESLLKYLIRMSTRSTPYGMLSGVALGEFSENNNIKIKDSSFHKKDVKIDGQWLYKLVHYLESDYTYYKDSFVIWNQQNYIYNNRLYLDNNSSITENKRNDVLSVKYNSILVFIHENSKKNITYEELVQLISSKYSIENKEEVKVFVQELINKEIIFSDLRPTLENKNPLDYIINSLNPKNSLVGTLINISNEITKYSKMPLGKGEYKYLDIVNLMSQLFVSKNYLQIDTYIDYSRNELKQSLADNISEAAYILWLLSPNHFGTKTIRNYHEFFMDKYGFEQLVNLKQLLSDINGFGYPKKDSYSFSNNIAFLKEKYLLAIQNNSHIEITENDVKNLEKNNTVSKINAPVSTEIYSEIYFGNSIKGYEDFAVISPILGSFNAGATFGRFTGNFNIKKKNQLQKEIVHHYNNYMNENGLEISQLNEGPLNSRNVNILNNNRIYNTCLNLNLPKSDIDINDIFIGATFNKLYLYSEKHDSRIVFVSNSMFNYEFGSELYKFLREISFEKTKFIQPITEEGIDSLPFCPRIIYKNIILKPATWKINSEMFSETENWLNRFATIREKWHIPKDVIIAFGDNRLLLNLLNDKHLIILKKELKKHGRIRILESFINESNNERMLEIVTPLYKKTSLKEQSFIIPKNRNKHFNNLKDWFSIHLSIPKTYQDNFIQDYLLPFITELKVNNFINKFFYIKFKEDEDFIKLRLLREDEDYSQIYSFIKNWKDYCLLNSELYDYSIVDYVPEVYRYGGPHVIEDIENFFMYDSLLSINIIQSEFKIPKEFIVAISIDFLLDYLEINKSEKEEILINNAEDLYRSNDIREYKNLLAKLTNPKNDYEILKKEFPNLHEFLFNKISILENLKKTLQKSLYTSRSRIIGSFIHMRCNRIFGINPEKEKFVLSIFNEITKTKKYWDGCD
What is the function of this protein?
Involved in the post-translational modification of the lantibiotic epidermin.
What are the official names of this protein?
Epidermin biosynthesis protein EpiB.
What is the protein family that this protein belongs to?
To B.subtilis SpaB and L.lactis NisB.
What are the subcellular locations of this protein?
Cell membrane. Note=Possibly associated with, and anchored to, the cytoplasmic side of the membrane.
Protein: AROC_EXIS2
Sequence: MRYMTAGESHGKGLSVIIEGIPSGLIIDFDQVQREMTRRQGGYGRGRRMQIEQDAVDVRGGIRHGYTTGAPISLFIENKDHTHWTKVMQAEPLQEELERPRTLTRPRPGHADLVGGLKYGHRDLRDVLERSSARETAARVAVGAIAKQLLGQLGIDVFSHVRSIGGIDADFVNPMEYREVIEASPVRCADEAAAERMMAAIDQAKKDGDTLGGEVEVVVTDMMPGIGSFTQNETKLDSRIARAVISVNAMKAVGFGDGFDLARRKGSTVQDEILHDETGYFRKTNHLGGIEGGMSTGMPIRVQVAMKPIPTLYRPLQSVDIETKEPFVAQVERSDACAVPAAAVVLEAVVAVEIAAAVLEMFGTSTLDRLKQAVTAYREEVRLF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RAC1_ARATH
Sequence: MSASRFIKCVTVGDGAVGKTCLLISYTSNTFPTDYVPTVFDNFSANVVVNGATVNLGLWDTAGQEDYNRLRPLSYRGADVFILAFSLISKASYENVSKKWIPELKHYAPGVPIVLVGTKLDLRDDKQFFIDHPGAVPITTAQGEELKKLIGAPAYIECSSKTQENVKGVFDAAIRVVLQPPKQKKKKSKAQKACSIL
What is the function of this protein?
Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.
What are the official names of this protein?
Rac-like GTP-binding protein ARAC1, GTPase protein ROP3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with the membrane when activated.
Protein: EFTU_MYCGE
Sequence: MAREKFDRSKPHVNVGTIGHIDHGKTTLTAAICTVLAKEGKSAATRYDEIDKAPEEKARGITINSAHVEYSSDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSATDSVMPQTREHILLARQVGVPKMVVFLNKCDIASDEEVQELVAEEVRDLLTSYGFDGKNTPIIYGSALKALEGDPKWEAKIHDLIKAVDEWIPTPTREVDKPFLLAIEDTMTITGRGTVVTGRVERGELKVGQEVEIVGLKPIRKAVVTGIEMFKKELDSAMAGDNAGVLLRGVERKEVERGQVLAKPGSIKPHKKFKAEIYALKKEEGGRHTGFLNGYRPQFYFRTTDVTGSIALAENTEMVLPGDNASITVELIAPIACEKGSKFSIREGGRTVGAGTVTEVLE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_ENT38
Sequence: MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGREFICIDTGGIDGTEDGVETRMAEQSLLAIEEADIVLFMVDARAGLMPADTAIAKHLRSREKPTFLVANKTDGIDADQAVADFWALGLGEIYPIAASHGRGVTSLLETVLMPWVDEINPPEEIDEDAAYWAQFEEAVEGKEEPVDDFNPQDLPIKLAIVGRPNVGKSTLTNRILGEDRVVVYDMPGTTRDSIYIPMQRDEREYVLIDTAGVRKRGKITDVVEKFSVIKTLQAIEDANVVMLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSNDVREQVKEMLDFRLGFIDFARIHFISALHGSGVGNLFESVREAYDSSTRRQSTAMLTRIMTMASEDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRKSLDVMGTPIRIQFKEGENPFADKRNTLTPNQMRKRKRLIKHIKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: OPUBD_BACSU
Sequence: MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAGILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTGAKHVQSAA
What is the function of this protein?
Involved in a high affinity multicomponent binding-protein-dependent transport system for choline; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Choline transport system permease protein OpuBD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: P65H_MYCGE
Sequence: MEKNRSAFQQNQQASNQPFNQDQNQYYQDPNQQQFNQSGFDPNQQQFNQPGFDPNQQYYQDPNQQQFNQAGFDQNQQYYQDPNQQQFNQPGFDPNQQYYQDPNQQQFNQAGFDQNQYYQDPNQQQFNQSGFDQNQYYQDPNQQQFNQPSFDLNNQQFNQPGFNQSPAFEITPQEQKAEQEMFGEEPPQVVREIHELPFEKIRSFLQSDFDSYNFRLNSLKSKLDNALYSLDKTIQNTNENTANLEAIRHNLEQKIQNQSKQLRTNFDTQKLDDKINELEIRMQKLTRNFESLSELSKHNSYPNYYEKLLPNGGDSMTNVFEKALMMNLLRTTLPPQPQVQYYPQPYPYIRPYYDEPIYAGFRRRGYRDDFYE
What are the official names of this protein?
Proline-rich P65 protein homolog.
Protein: ADDA_STRPS
Sequence: MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNILVSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLENEVFHEVFEAHYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSKSFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIDSLNQESDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADTYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRNRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKAHENLYEKLVNAQKKASSQKGLIHTALAEKLKQFMDILASWRLYAKPHSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLEAKQYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLRDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIKNIEKYLILLGKDEVQVVKV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RLME_BORPD
Sequence: MAKKKFSKDWIHQHINDPYVKMAQQKGYRARAAFKLIEILDTEKLMRRGDIVVDLGSAPGSWSQVARERLAGPGGVVDGRIIALDLLPMEPVAGVEFIQGDFRDEAVLQQLQEMVGGQPVSLVISDMAPNLSGVGVADSARIQHVCELALDFACNHLKPDGALIVKAFHGSGFSQIVQSFKQRFKRVVERKPKASRDKSSETFLVARDLKS
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RENT3_ARATH
Sequence: MKEPLQKKKVVVRHLPPSLSQSDLLSQIDPRFADRYNWVSFRPGKSSYKNQKYSRAYVSFKAPEDVYEFAAFFNGHVFVNEKGAQFKAIVEYAPSQRVPKPSDKKDPREGSISKDPDYLEFLKVIAQPVENLPSAEIQLERREAEQSGASKAAPIVTPLMEFIRQKRATVMGPQGLSDIRRGGRRTRVVSANKPSPRPSKRNSEKKKYVEKESSKNVPRKTTADVSSSKPDYRQSNSSGKELPGNETAAIIDSSPPGIALTMDSGKKKILLLRSKDRDNPDNPPPQPEQHIDTNLSRNSTDSRQNQKSDVGGRLIKGILLRNDSRPSQSSTFVQSEQRVEPSEAENYKRPSRPANTRAGKDYHTSGTISEKQERRTRNKDRPDRVMWAPRRDGSEDQPLSSAGNNGEVKDRMFSQRSGEVVNSSGGHTLENGSARHSSRRVGGRNRKEEVVIGEGKTSRRGSGGGPSSHEKQMWIQKPSSGT
What is the function of this protein?
Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD.  Binds spliced mRNA upstream of exon-exon junctions (By similarity).  Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery.  Eliminates the production of nonsense-containing RNAs (ncRNAs).  Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
What are the official names of this protein?
Regulator of nonsense transcripts UPF3, Nonsense mRNA reducing factor UPF3, Up-frameshift suppressor 3 homolog, AtUpf3.
What is the protein family that this protein belongs to?
Belongs to the RENT3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Protein: ALF1_STAAT
Sequence: MNKEQLEKMKNGKGFIAALDQSGGSTPKALKEYGVNEDQYSNEDEMFQLVHDMRTRVVTSPSFSPDKILGAILFEQTMDREVESKYTADYLADKGVVPFLKVDKGLAEEQNGVQLMKPIDNLDNLLDRANERHIFGTKMRSNILELNEQGIKDVVEQQFEVAKQIIAKGLVPIIEPEVNINAKDKAEIEKVLKAELKKGLDSLNADQLVMLKLTIPTEPNLYKELAEHPNVVRVVVLSGGYSREKANELLKDNAELIASFSRALASDLRADQSKEEFDKALGDAVESIYDASVNKN
What are the official names of this protein?
Fructose-bisphosphate aldolase class 1, Fructose-bisphosphate aldolase class I, FBP aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: SPEE_STRAW
Sequence: MIEPHAPAPPGAAPPWGGQSRPWLPVRPGVGRFFVLAGVFVCAACGLVYELELVALASYLIGDSVTQASVVLSVMVFAMGIGSLAAKRLRPHAAAGFGAIEAALALVGGSSAMALYAVFAWTGDWGGVWAGGPRCLLVAFSLAIGLLIGAEVPLLMELIQRIRRQDAGGAVADLFAADYVGALVGGLAFPFLLLPLLGQLEGVLLTGTVNALAGGALVLGLFRRDLTRRGRWLLIVVNLVVLGLLATAAVLVDDFERAARQAVYGRDVRVALQTGVQEVVLTGGTRGRPLDLFLDGRLRVSGHDERRYHEALVHPAMSDGRHARVLVLGGGDGLAAREVLRYADVARVDVVELDAGVVRLARRDPALSSLNAHAYDDPRVHVVTADAFCRLRHTRSAYDVVISDLPDPGITASTKLYSQEFYGLVSRVLAPGGRLVVHAGPVASRPRAYWTVEATVRAAGLRTVPYRVGGRDTGFAAGPDRSTDASRAPRDWGFVLASRTGPALSLGPGGPRLRTLTRASLAADALDPGRARPPDVAPSTLVHPRYAD
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZZZ3_HUMAN
Sequence: MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQVRSRSPKKRPEPVPIQKGNNNGRTTDLKQQSTRESWVSPRKRGLSSSEKDNIERQAIENCERRQTEPVSPVLKRIKRCLRSEAPNSSEEDSPIKSDKESVEQRSTVVDNDADFQGTKRACRCLILDDCEKREIKKVNVSEEGPLNSAVVEEITGYLAVNGVDDSDSAVINCDDCQPDGNTKQNSIGSYVLQEKSVAENGDTDTQTSMFLDSRKEDSYIDHKVPCTDSQVQVKLEDHKIVTACLPVEHVNQLTTEPATGPFSETQSSLRDSEEEVDVVGDSSASKEQCKENTNNELDTSLESMPASGEPEPSPVLDCVSAQMMSLSEPQEHRYTLRTSPRRAAPTRGSPTKNSSPYRENGQFEENNLSPNETNATVSDNVSQSPTNPGEISQNEKGICCDSQNNGSEGVSKPPSEARLNIGHLPSAKESASQHITEEEDDDPDVYYFESDHVALKHNKDYQRLLQTIAVLEAQRSQAVQDLESLGRHQREALKNPIGFVEKLQKKADIGLPYPQRVVQLPEIVWDQYTHSLGNFEREFKNRKRHTRRVKLVFDKVGLPARPKSPLDPKKDGESLSYSMLPLSDGPEGSSSRPQMIRGRLCDDTKPETFNQLWTVEEQKKLEQLLIKYPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNLYIYSKKSSTSRRQHPLNKHLFKPSTFMTSHEPPVYMDEDDDRSCFHSHMNTAVEDASDDESIPIMYRNLPEYKELLQFKKLKKQKLQQMQAESGFVQHVGFKCDNCGIEPIQGVRWHCQDCPPEMSLDFCDSCSDCLHETDIHKEDHQLEPIYRSETFLDRDYCVSQGTSYNYLDPNYFPANR
What is the function of this protein?
Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978).  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755).
What are the official names of this protein?
ZZ-type zinc finger-containing protein 3.
Protein: IXTPA_LACJO
Sequence: MDTLLFATNNKNKAREVEEALKKINFPIHVITNQDLTDPPHVLETGTTFLANAKLKAHKMAEFSNLPTLADDSGLSVDKLNGAPGVHSARYGGEAHNDALNNAKLLAELGGVPREKRQATFHTTMVVSWPGRFDDDLVTQGEIRGEILTYPRGDGDFGYDPLFFVPDKGKTFAEMTVDEKNAISHRGQALRKLLAELPTWWKKMENE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RL27_FLAJ1
Sequence: MAHKKGVGSSKNGRESESKRLGVKIYGGQAAIAGNIIVRQRGSKHNPGENVYISKDHTLHARVAGVVKFQKKRDNKSYVSIIPFEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: HV601_HUMAN
Sequence: MSVSFLIFLPVLGLPWGVLSQVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 6-1.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: RL21_IDILO
Sequence: MYAVFQSGGKQHRVSEGQIVRLEKLEAATGDVVEFDQVLMVSDGNDVNIGAPFVSGGKVKAEVIDHGRGDKIKIVKFRRRKHSRRQQGHRQWFTEVKITGINS
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: IF4E2_SCHPO
Sequence: MADAEDSRHSKNEGFPNTSLITEKLDLLDLFGSPKVKTEREGRPARLLEGLSAVNAETAFVKTHPLQHEWTLWFLKPPTQGLEWSDLLKEIISFKTVEEFWGIFKTISKASMLPAKSDYSYFLKGIRPEWEDPQNMNGGKWAYQSKHKGSNLDELWLYMVLAAIGETLDPTGKEVTGVVCNMRKGFYRIAVWTRNCNDKDVLEKIGLRFKEVLGISDKETIEYSAHEDSSKAGSMRAKTRMSL
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-2, eIF-4E-2, eIF4E-2, eIF-4F 25 kDa subunit 2, mRNA cap-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: CARB_LISMH
Sequence: MPKRDDIKTILVIGSGPIVIGQAAEFDYAGTQACLSLKEEGYRVVLVNSNPATIMTDAEMADKVYIEPITLDFVSRIIRKERPDAILPTLGGQTGLNMAMELSAAGILDECNVEVLGTDLTAIKKAEDREAFRDLMNELGEPVPESDIIHNLDEAYTFVERIGYPVIVRPAYTLGGSGGGICHNEQELIETVTSGLKLSPVTQCLLEKSIAGFKEVEYEVMRDANNNAMVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRDVSLKIIRALEIEGGCNVQLALDPDSYNYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVRNPVTGTTFAHFEPTLDYVVAKIPRFAFDKFEQADRRLGTQMKATGEVMAIGRSWEEALLKAVRSLEIGADHLLLEEAENADEATLERKICFPEDDRLFFLAAALRRGQTIEQLHAKTKIDLFFLYKLSKTIELENRIKENPHNQEILAEAKRAGFSDAFLATCWNVDEQAIYDLRKAQNLFPVYKMVDTCAAEFESTTPYFYSTYEEENESTRSAKESVIVLGSGPIRIGQGVEFDYATVHSVWAIQQAGYEAIIINNNPETVSTDFSISDKLYFEPLTLEDVMHVIEIEQPLGVVVQFGGQTAINLADGLAKRGVKILGTSLEDTDRAENRDAFEKALEILQIPQPAGKTATSVEEAINVATDIGYPVLVRPSYVLGGRAMEIVESEEALKHYMTNAVKVNPKHPVLVDRYVSGQEVEVDAISDGENVLIPGIMEHIERAGVHSGDSIAVYPAQRLSSQVKNTIVDYTTRLATGLNIIGMLNIQYVVDGEEVFVIEVNPRSSRTAPFLSKITEIPMANVATRVILGENLIDLGYTPGLAPEKQEIFVKVPVFSFAKLRSVDTSLGPEMKSTGEVMGKDVTLEKALYKGFVASGTTMHDYGTVLLTVADRDKEEAVELAKRFNRIGFTIMATKGTASTLEEADIPVSQVKKIGENQETLIDYIRNGQVTLVVNTLTTGKRPERDGFQIRRESVENGIPVCTSLDTAEAILRVLESRSFELESMNASEVKQPKARV
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: VAPC2_RICFE
Sequence: MIYMLDTNICVYAINKHPDSYYNNLELLAKNNTIAISSIVLAELQYGVSKSKKKEQNQSKLDIFLSRLEIIDFSAKCTFYYGELRTELEQKGLIIGNNDLLIASHAIAENATLVTNNIKEFKRIPNLILENWDK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Has ssRNase activity.  Upon expression in E. coli or S. cerevisiae inhibits growth in liquid culture; in S. cerevisiae its expression leads to apoptosis-like characteristics.  Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them.  Probably contributes to host cell death if bacterial cell lysis occurs during host infection.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its RNase activity is partially inhibited in vitro by VapB2 (PubMed:22046301).
What are the official names of this protein?
Ribonuclease VapC2, RNase VapC2, Toxin VapC2.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: ATG4B_DANRE
Sequence: MDAATLTYDSLRFGEIEDFPETSDPVWILGKQFSALTEKDDILADVTSRLWFTYRKNFQPIGGTGPTSDTGWGCMLRCGQMILGEALICRHLGRDWKWSPGQRQRPEYVSILNAFIDKKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDSWSRLAVHVAMDNTVVIEEIKRLCMPWLDFDRGACAVSEEPREMNGDLEGACALAEEETALWKPLVLLIPLRLGLSDINEAYIEPLKQCFMMPQSLGVIGGKPNSAHYFIGFVGDELIYLDPHTTQPAVDPSEDGHFPDDSYHCQHPPCRMHICELDPSIAAGFFCQTEDDFDDWCAQIRKVSNCRGLPMFELVDSQPSHLITADVLNLTPDFSDSDRLERFFDSEDEEFEILSL
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3.  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.  Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS).
What are the official names of this protein?
Cysteine protease ATG4B, Autophagy-related protein 4 homolog B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum. Mitochondrion. Note=Mainly localizes to the cytoplasm, including cytosol.
Protein: NU4LM_DAUMA
Sequence: MPLISINLSLAFTTALLGVLMFRSHLMSSLLCLEGTMLSMFILTTLSTLNLHYNLSSTLPIILLVFAACEAAAGLALLVTVSNTYGLDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL17_ARTS2
Sequence: MPTPTKGPRLGGGPAHERLMLANLAAALFEHKRITTTVTKAKRLKPYAERLVTFAKRGDLASRRRVLGLISNKGVVHELFTDIAQAVENRDGGYTRITKIGNRKGDNAPMAVIELVLEPVSAKQAVVAEATSAAKRDADKKEAAAAPAAETEVAETEAAPEAEAAEAPKAEAAETEEAPAAEEAAEKPAAEEKDAK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.