PharMolix/UniProtQA huggingface dataset:
Protein: DIAA_SHISS
Sequence: MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: CDD_VIBC1
Sequence: MKSRIEQALASAPEALSTHLAPIVLADDFDATISEQQFGELLNATNLSDKELRVALLPFAAAFSYAPISEFYVGAIVRGLSGRLYFGANMEFFGVQLGQTVHAEQCAISHAWMKGEHGVKDITINYSPCGHCRQFMNELSTAKELKIQLPERQEKSLHHYLPEAFGPADLGIESGLMAEVKHEFVCDEDDALIQKAVNAMNISHAPYTNNLSGIALEMNSGLVFQGAYAENAAFNPSLPPLQVALIQILMAGEKFEDIKAAALVENSQGKISHLADTQSTLEALNPDIPVSFVNV
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: LALBA_NOTEU
Sequence: MMSLLSLLLLGIALPATQAIDYRKCQASQILKEHGMDKVIPLPELVCTMFHISGLSTQAEVNNHSNKEYGIFQISNNGWCAEKQEDVANSVCGILCSKFLDDDITDDIECAKKILQLPEGLGYWKAHETFCIEDLDQWRC
What is the function of this protein?
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme.  This enables LS to synthesize lactose, the major carbohydrate component of milk.  In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
What are the official names of this protein?
Alpha-lactalbumin, Lactose synthase B protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1996_DICDI
Sequence: MQQPISIQQPVVNNINNSPNNQANINNNTTNNTNNNNNNNNTTNNIANNNNSNNINNNNEINNSNINNNINNGINNDIDRGGEKKANKLIAKTTKKFNKDMTAYTSGKFFELWRNQVVRDKILGYVRIHNLHYDKRVFKCIDLNNCIDNGADLQQQHNCHRVHNHYHQDLGHNYFGKVSRGIVSLSDYKYYGYLRSVHLIGYEQHEEELIKTIKSLPVGVSTLELSGHLNKIIFKEGSLPTSITNLTISSPTKLGYKSIPSHLKTLKLNSTFNDPLLVQGRLEGQLGIVPLLPIDGAITSLDTGGKFNQPFEAGLLPSSLTELAFGNEYFRPIEVGSLPSGIKSLKLGQRFCLPIPIGSLPIGLTELQLGGTQQNPILTIGCLPPTLTKLTLDNHFNQPLVIGVIPSSLKTMIFGPRYNQPLPPSVFPDSLTHLEFHQNSSYIFPLKLGYNIPSNVSTLLLSFRSQERNVTLGTNSNIKKLRCGGDYLPSLSSDDSTIGAILNSFSSSSSRETFPRSVESLHLNIVNVLDKEINIPSNVTKLIITGNNLQHDGPDVFMVGKKGSKITHLKLRGYEKPICQEMFKNLVNLKSIQFIGAYNHQLGPNCFPPQSITNLEFDCLPSVIPIGSLPSTLKSLRVKSFCTPFLKNSLPSSLLILECAFVRSFIDSYEIVDEIFVEQQAQYAQQQLLQNEQALQAQKQLEIQQQVAQQRLQQLKQQKQQQQQQQDNEQQLDHSIENNDGSIQDDHEHELEEEQENEEEEEDTNNHQHPFLQEAINHNQQLQQKQQEKYLYSSNNSNNYNYNNNSNNNNNNNSNEEDDEEEDLIQPIISKEWLPPSIHTLIIRGEPTIQLPLPESLTNIHIESKNQSILHNIPLMEKISKLVRVFDYESDTNSIFKKSLAICNNINQNQNQNNNNYNNNNNNNNNNNNNKKKNVKK
What are the official names of this protein?
FNIP repeat-containing protein DDB_G0271996.
Protein: ANMK_NOSS1
Sequence: MYSSQASAVPNRVVGLISGTSVDGIDAALVEITGTELDLKVELLAGKTYPYPADLRERILAVCAGEAISMLELAHMDDAIALAFAQAAQNIQIGYQPANLIGSHGQTVYHRPPKEAGVGKKNLGYTLQLGRGEMIAYLTGITTVSNFRVADIAVGGHGAPLVPRVDAFLLSHPHESRCIQNLGGIGNLAYIPARTDDWLSQICGWDTGPSNSLLDLAVERLTAGAKTYDEDGQWAASGTPCYPLVEKWLTHEYFHLSPPKSTGRELFGVAYLNQCFQDAEPYQLSPADMLATLTELTVASIVHSYRTFLPQMPQRVFLCGGGSRNLYLKQRLQLALETVPVLTTDEAGVSADFKEAIAFAVLAHWRQLAIPGNLPTATGAPHEVLLGEIHQG
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: APT_LACDB
Sequence: MSIDFKKYIASVKDFPNEGIIFRDITPILQDGEAFAAATHEIAEYAKSRQADVIVGPEARGFLVGTPVAIELGIGFVPARKPHKLPREVEAAAYDLEYGSNVLEMHKDAIKPGQRVVICDDLMATAGTMHATKELIERLGGKVVGAAFYIELTDLKGREKFPDVDIFSLVQYTGA
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_BACFR
Sequence: MKVDVLLGLQWGDEGKGKVVDVLTPKYDVVARFQGGPNAGHTLEFEGQKYVLRSIPSGIFQGDKVNIIGNGVVLDPALFKAEAEALEASGHNLKERLHISKKAHLILPTHRILDAAYEAAKGDAKVGTTGKGIGPTYTDKVSRNGVRVGDILHNFEQKYAAAKARHEQILKGLNYEYDLTELEKAWFEGIEYLKQFQLVDSEHEINGLLDNGKSILCEGAQGTMLDIDFGSYPFVTSSNTVCAGACTGLGVAPNKIGDVYGIFKAYCTRVGSGPFPTELFDKTGDQICTLGHEFGSVTGRKRRCGWVDLVALKYSIMVNGVTKLIMMKSDVLDTFETIKACVAYKMNGEEIDYFPYDITDEVEPIYVELPGWQTDMTKMQSEDEFPEEFNAYLSFLEEQLGVQIKIVSVGPDREQTIIRYTEE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK16_LOTJA
Sequence: MLSPKRTRFRKQHRGRMKGISHRGNQICFGRYALQALEPAWITSRQIEAGRRAMSRNVRRGGQIWVRIFPDKPVTVRPTETRMGSGKGSPEYWVAVVKPGKIVYEMGGVAENIARKAISIAASKMPIRTQFIISG
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PEPC_MACFU
Sequence: QLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYHFGDLSVSYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPTLSVDGATTAMQGMVQEGALTSPIFSVYLSDQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPTLTFIINGVEFPLPPSSYILNNNGYCTVGVEPTYLSAQNSQPLWILGDVFLRSYYSVYDLSNNRVGFATAA
What is the function of this protein?
Hydrolyzes a variety of proteins.
What are the official names of this protein?
Gastricsin, Pepsinogen C.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURQ_SHIDS
Sequence: MQLEKMITEGSNAASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGINDLKNIGLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAITPVVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVNIVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: UVRC_FRATT
Sequence: MIVDNSKDFDLKSFLANLTTHSGVYRMLDKHGEIIYVGKAKNLKNRVNSYFSKGAKDSKTLMMVEQIARIEITITPSDYEAYLLENNLIKQHRPKYNILFKDDKSYPYLVISRDKFPRVSFYRSKSAYKKGQCFGPYVSISSVKNTLNTIQKIFPIRQCENSYYKSRVRPCLQYQIKCCLAPCVGLVSQQQYDEQLAILKKFLAGKFSSVLEEISAKMYQASEDMEYEKAQVYRDQLVVLRKLQQQQIVDIQEDKTFDVIGIYMQDSYASIALLQIQNGDVVADRHWSIDAKGQDKTSIMHAFLSHFYLGDEIRNIWPKNIILSKVEFADITDLMNSISQKIGQAINWIIAPAADNLKWLKLAEVNARQKLNIYTSSKSQYQKRLESLKEFLELEKDIKRIECFDISHFQGEATIASCVVYTDDGEDRKSHRRYNIKDIKSGDDYAAIHQAVSRRVSSGLEADNLPDVMIIDGGKGQIHQAEAVFREYGIQDKVQLVSLGKGIERISGKEKIYKGFDDTEYTLDEHNPGFLLLRQVRDSAHDHAIKGQRKKVSANRQSSIIEEIEGVGPKRRKALMMYFGGWQELSRASVDEIAKVKGISKKLAQEIWECFH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUK_BACC4
Sequence: MSVNRILVINPGSTSTKIGVFDNERPVLEETIRHDVEQIGKYKRIIDQYEFRKETILEVLHSHGINISKLNAVCGRGGLLRPIEGGTYTVNDAMLEDLKNGFSGHHASNLGGILAYEIASGLNIPAFIVDPVVVDEMEPVARISGIAGMERKSIFHALNQKAVARKVAEQLNHKYEDLNLLVTHMGGGITVGAHKKGRVIDVNNGLNGEGPFSPERAGTVPVGQLVEMCFSGEYYRDEMIKKLVGQGGLVSLIDTNDAIKVEQMVEKGDPEATLIYKAMAYQVAKEIGGASAVLHGKIDAIVLTGGLAYSKILVDEIKERVDWIADVIVHPGEDELEALAEGALRVLREEEAPKEYVVREKETVARG
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_SHEDO
Sequence: MRIGILGGTFDPIHYGHIRPALEVKNALNLDSIWLMPNHIPPHKAGPKTGTAHRLAMVQLVCSQHNEFELCDIEINRDTPSFTVTSLQQLTQAYPEHEFYFIMGMDSFIQLDRWYQWQTLFELCHIVVCQRPGWQLEYTSPMATLMQIKVQQQAIKGNSIKETKVGSIFPVNITAQDISSTEIRAQISAQSMNNQALSPLLPANIIDYIKQHQLYR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: HIS8_NOCFA
Sequence: MSAPTVPGAGIGLDDLPLRANLRGKKPYGAPQLTVPVQLNTNENPHPPSKALVDDVAESIRAVAAELHRYPDRDAVALRADLAAYLTRQTGIAVDTANVWAANGSNEILQQLLQAFGGPGRRALGFVPSYSMHPIISEGIDTEWVEARRNADFSLDIDHAVATIAERRPDVVFVTSPNNPTGHSIPGADLARILDAAPGIVVVDEAYAEFSAQPSAIGLIDRYPAKLVVSRTMSKAFAFAGGRLGYLVAAPAVIDALLLVRLPYHLSVVTQAAARAALRHADETLASVAELAAQRDRVAAELAASGFRVVPSDANFLLFGRFADAPRAWQRYLDHGVLIRDVGIPGHLRATIGLAAENDEFLRVSRLLAADELINDESDESTGTP
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: MURD_STRCO
Sequence: MPSEFSGKHVTVAGLGVSGVPAAKVLHGLGAQVTVVNDGDDERARTQAAELEPLGVTVRLGDGDTLPEGTELIVTAPGWKPTKPLFTAAGQAGVPVWGDVELAWRLRGLNGRKPAPWLAVTGTNGKTTTVQMLASILKAAGLRTAAVGNIGVSLLDAVTGEQEYDVLAVELSSYQLHWAPSLRAHSAAVLNLAPDHLDWHGSMEAYAADKGRIYEGNHVACVYNVADKATEDLVRAADVEEGCRAIGFTLGTPGPSQLGVVEGLLVDRAFVEDRQKNAQELAEVSDVNPPAPHNIANALAAAGLARAFGVSAAAVRDGLRAFTPDAHRIAHVADVDGVAYVDDSKATNTHATEASLAAYESIVWIAGGLAKGATFDELVAGAAKRLRGAVLIGADRALIREALARHAPEVPVVDLDRTDTGAMLQAVQEARRLARPGDTVLLAPACASMDMFTNYNQRGDAFAQAVRELGA
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUXG_ARATH
Sequence: MSRSGQPPDLKKYMDKKLQIKLNANRMVTGTLRGFDQFMNLVVDNTVEVNGNDKTDIGMVVIRGNSIVTVEALEPVGRSS
What is the function of this protein?
Probable common Sm protein, is found in U1 and U2 snRNPs and may be part of the spliceosome.
What are the official names of this protein?
Probable small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROA_PHODP
Sequence: MESLTLQPINLINGEVNLPGSKSVSNRALLLAALAQGTTRLTNLLDSDDIRHMLNALQQLGVQYQLSADKTECTVEGLGQPFSVKDFTCLYLGNAGTAMRPLAAALCLGQGEFELTGEPRMKERPIGHLVDALRSAGADITYLENEHYPPLKIKGTGLDGGEVSIDGSISSQFLTAFLMAAPLAKSDTTILIKGDLVSKPYIDITLNIMAQFGVQVENQNYQKFIVPAGQVYQSPGEFLVEGDASSASYFLAAGAIKGGEVKVTGIGKNSIQGDIQFADALEAMGAEIEWGEDYIIARHRQLNAIDMDFNHIPDAAMTIATAALFAPGTTSIRNVYNWRVKETDRLHAMATELRKLGAEVEEGDDYITITSPTQLKHVAIDTYDDHRMAMCFSLVALSDTAVTINDPKCTSKTFPDYFTKLEQLSR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEC3_CAEBR
Sequence: MEVLESKPLSAISMVIDAIGVEHDSQNKCYCCNEQIFDRFICRMDNRSYHENCVKCAICESPLAEKCFWKNGTIYCSQHYYKDYSAHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCTLCGRHLSPGEQILVDDTMMTVSCMSHYPLPMDDPCPPVGPSDVPSCSSDASAVAPYPMDESFPFQIKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIRQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDGTDFNSFCGNFEEEDDED
What is the function of this protein?
Specifies differentiation of the set of six touch receptor neurons.  Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.
What are the official names of this protein?
Mechanosensory protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_METC4
Sequence: MSNKNEALLRRKARVRRALRAAANGRPRLSVFRSSKQIYVQVIDDAAGRTLAAASSLDKDLKSSLKTGADKAAAEAVGKLVAERAKAAGVTKVVFDRSGYIFHGRVKALADAAREGGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: STK4_PAPAN
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: SYP_IDILO
Sequence: MRSSKYLLSTLKETPSDAEIVSHQLMLRAGMIRKVAAGLYTWTPTGLRVLRKVENVVREEMEAINALEILMPMVQPADLWQESGRWDDYGPELLRIKDRNQRDFLLGPTHEEIISQLVRKEVSSYKQLPLTLFQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHLTDESLQKTYDDMYKAYCRIFERLGLDYRPVIADTGSIGGSHSHEFHVLASSGEDAIAFSDSSDYAANVEMAEALAPAGERPAPNQKVEKHEVQGDELAAVLQPLSVESQQATKSFIVKAADDIDSEYVQLVLRADHELNTVKAEKLAQVAAPLEILTETEKATGVEAPYIGVVNAKLPLLVDSSAAHLADFACGANENGQWLTGVNWKRDTGDFSVVDIRNVVAGDPSPCGQGKVKIARGIEVGHIFQLGKKYSDAMKVGVLSESGKHETLTMGCYGIGVSRIVAAAIEQNNDERGICWPEALAPFQVVIVPMNMHKSARVQEAAEKLYTDLKAQGIDVLFDDRKERPGVMFTDMELIGIPHQVVVGERNLDENQVEYQSRKGGEKQKINLDDCISFIQQQL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1556_MYCTU
Sequence: MVGAVTQIADRPTDPSPWSPRETELLAVTLRLLQEHGYDRLTVDAVAASARASKATVYRRWPSKAELVLAAFIEGIRQVAVPPNTGNLRDDLLRLGELICREVGQHASTIRAVLVEVSRNPALNDVLQHQFVDHRKALIQYILQQAVDRGEISSAAISDELWDLLPGYLIFRSIIPNRPPTQDTVQALVDDVILPSLTRSTG
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator Rv1556.
Protein: UCPA_SALTY
Sequence: MGKLTGKTALITGASQGIGEGIARVFARHGANLILLDISDEIEKLADELGGRGHRCTAVKADVRDFASVQAAVARAKETEGRIDILVNNAGVCRLGNFLDMSEEDRDFHIDINIKGVWNVTKAVLPEMIKRKDGRIVMMSSVTGDMVADPGETAYALSKAAIVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQSNPDDPESVLTEMAKAIPLRRLADPLEVGELAAFLASDESSYLTGTQNVIDGGSTLPESVSVGV
What are the official names of this protein?
Oxidoreductase UcpA.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SLE1_STAHJ
Sequence: MNKKILATAVLGTGALSTLFAHQAEASTTHTVRSGESLWSISHHYGITVSKLKSLNGLSSNLIFPNQVLKVSGSSNYSSRSNYGNSSSTYTVRAGDSLSSIASRYGTTYRHIMNLNGLNSFLIFPGQQLKVSGSVSSNSHSSYNSNSGGSSSTYTVRYGDSLSSIASRYGTTYQHIMRLNGLNNFFIYPGQKLRVSGSASSNTYSTRSAQSTYYSSPVFNHRNLYDWGQCTWHVFNRRAAIGKGISTYWWNANNWDNAAARDGYRIDGNPTVGSIAQSDAGYYGHVAFVERVNSNGSILVSEMNFSASPGILTYRTIPAYQVRNYKFIH
What is the function of this protein?
Peptidoglycan hydrolase involved in the splitting of the septum during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase sle1.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: BURS_BOMMO
Sequence: MSVLNTFLVIVALILCYVNDFPVTGHEVQLPPGTKFFCQECQMTAVIHVLKHRGCKPKAIPSFACIGKCTSYVQVSGSKIWQMERTCNCCQESGEREATVVLFCPDAQNEEKRFRKVSTKAPLQCMCRPCGSIEESSIIPQEVAGYSEEGPLYNHFRKSL
What is the function of this protein?
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading.
What are the official names of this protein?
Bursicon, Bursicon subunit alpha, Cuticle-tanning hormone.
What are the subcellular locations of this protein?
Secreted.
Protein: DLTC_STRTD
Sequence: MDVKAEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVELESRFDIRVPVSEFGRDDWNTANKIVEGVTELRNA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WAP1_THRJA
Sequence: MKARLLLLSVVILVGMVSAENEKAGSCPDVNQPIPPLGLCRNMCESDSGCPNNEKCCKNGCGFMTCSRPR
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Waprin-Thr1.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMB_PROMH
Sequence: MKTSYNLRSIAAKAIAQVLDQGLSLSSVIPELQKNISDKDKALLQELCFGTLRTLPQLEWIIQQLMDKPLKGKQRILHYLIMVGLYQLLYTRVPAHAALAETVNGAIALKKPQLKGLINGVLRQFQRQQDVLMERFQNNDSRYLHPSWLLTRIKNAYPELWESIIEGNNQKPPMWLRVNQIHHSREQYLALLEKEGISAFSDDHHPNAIRLETPCNVHLLPGFNEGWVTVQDRSAQRCAELLAPQNNEQILDLCAAPGGKTTHILEIAPKAHVLAIDIDEQRLARVKENLNRLKLHATVKSGDGRYPEQWCANMQFDRILLDAPCSATGVIRRHPDIKWLRRNEDIAQLAQIQKEILHAIWPYLKSGGTLVYATCSILPEENSQQIAAFLSSMQDAQCDYQHQCLPEQYSGDGFFYALINKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT1_COLLI
Sequence: MDSQDCPCAAGGTCTCGDNCKCKNCKCTSCKKGCCSCCPAGCAKCAQGCVCKGPPSAKCSCCK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-1, MT-1, Metallothionein-I, MT-I.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.