PharMolix/UniProtQA huggingface dataset:
Protein: SAHH3_BOVIN
Sequence: MSVQVVSAAAAAKVPEVELKDLSPSEAEPQLGLSTAAVSAMAPPAGGGDPEAPAPAAERPPAPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGNSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIILLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY
What is the function of this protein?
May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity.  On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity).
What are the official names of this protein?
Adenosylhomocysteinase 3, AdoHcyase 3, IP(3)Rs binding protein released with IP(3) 2, IRBIT2, Long-IRBIT.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm. Microsome. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1.
Protein: HBB_ALLMI
Sequence: ASFDAHERKFIVDLWAKVDVAQCGADALSRMLIVYPWKRRYFEHFGKMCNAHDILHNSKVQEHGKKVLASFGEAVKHLDNIKGHFANLSKLHCEKFHVDPENFKLLGDIIIIVLAAHHPEDFSVECHAAFQKLVRQVAAALAAEYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SECA_RHOPA
Sequence: MIGALARKLFGSANDRRVKGYQTRVAAINALEPEVAALSDEALRARTAEFRAELAAGKTLDDLLVPAFATVREAAKRTLGQRHFDVQLIGGMVLHEGDIAEMKTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLAKRDSGWMGQIYGFLGMTTGVIVHGLDDAQRQAAYACDITYGTNNEYGFDYLRDNMKYRLEDMVQRGHNFAIVDEVDSILIDEARTPLIISGPLDDRSDFYNTIDTFIPRLDKSDYDVDEKQRTVTLTEAGMEKIETLLRDAGQLRGESLYDVENVSVVHHVNQALRAHALFQRDKDYIVRNDEVVIIDEFTGRMMQGRRYSEGLHQALEAKEHVTVQPENQTLASITFQNYFRMYDKLAGMTGTASTEADEFFDIYKLEVVEIPTNLPIARLDEDDEVYRTQQEKYAAILAEVERANKRMQPVLVGTASIEKSEVLAEYLKKNGYKQIDFTDPKGMDKLYAAARAGKPAKLFAVLNARFHEQEAYIVAEAGVPGAITIATNMAGRGTDIKLGGSLEMRIQQEAAHITDEAERAAKITEIKADIERFRDIVLKAEDEIEIEPAKGNKPAKTAKRPGGLYIIGSERHESRRIDNQLRGRSGRQGDPGRSKFFLSLEDDLMRIFGSDKLDTMLTRLGLKEGEAIIHPWINKALEKAQQKVEARNFDIRKNLLKFDDVQNDQRKVIFDQRIELMKEDSVAETVTDMRHTYIEDLVAKYVPEHAYAEQWDVAGLKAEVERVVGLDIPVDEWAKEEGIADEELITRLERVFDEHMAAKVGQWGSDVMRYAEKSILLQTLDHLWREHLVMLDHLRQVIGLRGYGQRDPLQEYKSEAFNLFQEMSSHLREAVTAQLMRVEIIPPDQPQELPPMEVHKMDPDTGQDEMALANVTLAPAQTTDKADRDPNKPETWGKVGRNEDCPCGSGKKYKHCHGRYA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CAPP_BURVG
Sequence: MKSSGSARTARRNAALPSTDAQTGALATVANGRAKPATKPKDSIRQTKRTTKAAGASKPAARTREDKDGPLFEDIRFLGRLLGDVVREQEGDTVFDVVETIRQTAVKFRREDDSQAAQTLEKKLRKLTPEQTVSVVRAFSYFSHLANIAEDRHHNRRRRIHALAGSAPQPGTVAYALEQLKTSGNASKRVLQRFFDDALIVPVLTAHPTEVQRKSILDAQHDIARLLAERDQPLTARERAYNESMLRARVTALWQTRMLRDARLTVGDEIENALSYYRTTFLDELPALYGDIEAALAEHGLPARVPAFFQMGSWIGGDRDGNPNVTAATLDEAINRQAAVILEHYLEQVHKLGAELSVSNLLVGANDAVKALAAASPDQSPHRVDEPYRRALIGIYTRLAASARVRLGEGTVPVRSAGRGAPPVRAVPYADSEAFVADLKVLTASLEEHHGASLAAPRLTPLMRAAEVFGFHLSSIDLRQSSDIHEAVVAELFARAGVHADYASLSEDDKLIALLAALADPRPLRSPYIEYSALAQSELGVFEKAREVRAQFGPRAVRNYIISHTETVSDLVEVLLLQKETGLLEGAFGAAHDSARNGLMVIPLFETIPDLRDAARIMREYFALPGIEALIAHQGAEQEVMLGYSDSNKDGGFLTSNWELYRAELALVDLFRDRKITLRLFHGRGGTVGRGGGPTYQAILSQPPGTVNGQIRLTEQGEVIASKFANPEIGRRNLETVVAATLEASLLPQSNAPAQLPAFEAAMQALSDAAMASYRALVYETPGFTDYFFAATPITEIAELNIGSRPASRKLQDPKNRRIEDLRAIPWGFSWGQCRLLLTGWYGFGSAVSAYLDGAPDAAARTKRVALLKKMNKTWPFFANLLSNMDMVLAKTDLAVASRYAQLVADRKLRKHVFERIVAEWERTAQALAEITGHEGRLATNPLLARSIKNRFPYLDPLNHLQVELIKRHRAGDTNARLRRGIHLTINGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: FABH1_STAES
Sequence: MNVGIKGFGAYAPKNIIDNAYFEQFLETSDEWISKMTGIKERHWADEDQDTSDLAYNASIKAIEDAGIQPVDIDMIIVATATGDMPFPSVANILQERLGTGKVATMDQLAACSGFMYSMITAKQYIQSGDYKHILVVGADKLSKITDMTDRSTAVLFGDGAGAVVMGEVAEGRGIISYEMGSDGSGGKYLYLDRETGKLKMNGREVFKFAVRIMGDASTRVVEKAGLSSEDIDLFVPHQANIRIMESARERLGIEREKMSVSVNKYGNTSAASIPLSINQELQNGKIKDDDTLVLVGFGGGLTWGAIVIKWGK
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III 1, Beta-ketoacyl-ACP synthase III 1, KAS III 1, 3-oxoacyl-[acyl-carrier-protein] synthase 3 1, 3-oxoacyl-[acyl-carrier-protein] synthase III 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSB6_YEAST
Sequence: MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC
What is the function of this protein?
May play a role in endocytic and/or exocytic pathways.
What are the official names of this protein?
Phosphatidylinositol 4-kinase LSB6, PI4-kinase, PtdIns-4-kinase, LAS seventeen-binding protein 6, LAS17-binding protein 6.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Located at both the plasma and vacuolar membrane.
Protein: MQO_LEIXX
Sequence: MSNDPIDVVLIGGGIMSATLGAMIQRVQPGWSIRIYESLGEVAQESSNPWNNAGTGHAALCELNYMPEAEDGTVDPAKAISINEQFQLSRQFWASLVAAGDLPEPQTFINSTPHMTFVRGRENVRYLRRRYEELKDQPLFAGMEYSEDAETIAEWAPLLTKKRNRKQRIAATRQLAGTDVDFGALTRALVDDLVASGAELALNHRVCSLKRTKDGLWRIRARHEVGRTPREALARFVFVGAGGGALHLLQKSGISEIEGFGGFPISGQFLRTTNPAIVAQHKAKVYGKAAVGAPPMSVPHLDTRVVDGETSLLFGPYAGFSPKFLKTGTWWDLPGSIRLGNIGPMLAVARDNFDLMKYLIGELMAGREKKLAALREFMPTAKSEDWELIAAGQRVQVMKKDERKGGVLQFGTEVIAAADGSIAGLLGASPGASTAVPIMVDLLKRCFPERFEGWLPVLRELIPTVGTTLNDRPEEAEFVLKRTAAVLKLAQ
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: UREG_YERE8
Sequence: MNSHSTDKRKKITRIGIGGPVGSGKTAIIEVITPILIKRGIKPLIITNDIVTTEDAKQVKRTLKGILDEEKILGVETGACPHTAVREDPSMNIAAVEEMEERFPDSDLIMIESGGDNLTLTFSPALADFYIYVIDVAEGEKIPRKNGPGLVQADILVINKIDLAPYVGASLDVMESDTKVVRGERPYILTNCKTGQGIEELVDMIMRDFLFTHVQPQGEHA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_METBU
Sequence: MNTTDDVSCAEIYVSGRVQGVYFRGFTQKTATSLGLMGYAQNLPDGRVKVVAQGKRSCISELLDHLHIGPELSNVECIEVGWMGLSDTFTDFFIKR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: INS_PTYDH
Sequence: APNQRLCGSHLVEALFLICGERGFYYSPRTGIVEQCCENTCSLYELENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDPA_NOSS1
Sequence: MGQGLLQIGLTLCIVIAITPVLGRYIARVFLGERTILDRVMNPIERSVYVISGVRPKDEMTGWQYIRAILYTNLFMGILVYSLIYFQRLLPWNPNGLGVPSWDIVLHTVISFVTNTDQQHYAGETTLSYFSQVAALGFLMFTSAATGLAVGIAFIRGLTGRKLGNFYVDLTRGITRILLPISVIGAIALVLLGVPQTIGETLTITTLEGGTQYIARGPVASFEMIKMLGENGGGFFAANSAHPFENPNGLTNLIETIAMIAIPAAMIYTYGVFAKNIKQAWLLFWMVFIVFVILVWVAAGGELQGNPLVNGTLGIEQPNLEGKEVRFGWAETALWAVMTTATMCGAVNGMHDSLMPQGLFATLFNLFLQIIWGGQGTGTAYLFIYLILTVFLTGLMVGRTPEIFGRKIEKREIVLASLILLIHPIVVLIPSAIALAYPFSLSGISNPSFHGISQVVYEYASASANNGSGLEGLTDNSLWWNLSTSLSILTGRYVPIIAMLLLADSMSRKQTVPQTPGTLKTDSLIFTTVTAGIVLILGVLTFFPVLALGPIAEGFKLASGS
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCKA_ALKOO
Sequence: MNNVKELIDSGILKTNKIHYNLPVEELIKIAVEKEGGVIAKNGALCINTGKYTGRSPEDRFIVDEPSVHDHINWNKGNKGISAQVFDNLFNKAMAHVKDKELFVFEGFVGSDLDYRMPIRVINEFAYQNLFASQMFIKPKAGERENFDPEFTVLALPDLKADPAVDGTNSEVFIILNFAQKIVLIGGTRYSGEIKKSIFTVMNYLLPFKDVLPMHCSANIGEDGNVALFFGLSGTGKTTLSADNNRKLIGDDEHGWTANGVFNFEGGCYAKCINLTEEQEPQIWNAIKHGAILENIVIDENTGHIDYDDDRYTENTRAAYPVEYIDDAVLEGKGGIPNTIIFLTADATGVLPPIAKLTKEQAMYHFMSGYTSKLAGTERGIVEPTATFSTCFGGPFMLLKPQTYAKLLGEKIEKYNTRVFLVNTGWTGGPYGIGSRMKLKYTRSMVRAAIKGELDQVEYIKDPIFNLSIPTTCPEVPVEVLEPSKTWDNQDEYDQKANELAKSFVENFKKFDDVSDDIKNVNPKVQ
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAKD4_RAT
Sequence: MAVRLMKQCTCLLREATRLVPTVAPVGRLRLAGVACKTLTSSVSSPSSGSLTELLGKEQVFTPYPEHQEVDYLIEKATRPEELLELLGGDHSLHHNHAALILIRLSYLLSEKPKEKALLVEDARFQQLVRLVDSQITSVWHGTLVKLLRSLYTLVLPQGSKELRSVEQEVRWRLRRLKYKHLVFLAESCAPFMKEQHSKELLAELLRHLERRWTEISDSRTLVSMMTMAGHLSESLMNRLEDKCLELVEQFGPDELRKVLMTLAAQSRRSVPLLRAISYHLVQKPFPMTKGMLLDLAYAYGKLSFHQTQVAQRLAADLLPFIPSMTPGEVARCAKSFAFLKWLNLPLFEAFTQHLLNSAQDVSLSHLCSVLLAFARLNFHPEQEDQFFNLVHEKLDSVLGSLEPALQVDLVWALCVLQQVQVAELQTVLHPGLHTRFLESKSPKDQSTFQKLVHINSTALLEYPEYKGPFLPASAVAPSPSPSNKKMTPLQKELQDALKALLGNNDTGSLEVATQYGWVLDAEVLLDAEGHFLPLRDFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNFNSRSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKTAYLKDKMRKAVAEELAK
What is the function of this protein?
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.  May play a role in cell cycle progression.
What are the official names of this protein?
FAST kinase domain-containing protein 4, Protein TBRG4, Transforming growth factor beta regulator 4.
What is the protein family that this protein belongs to?
Belongs to the FAST kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CEGT_XENTR
Sequence: MAVLDLALQGLAIFGCVLFFVLWFMHFLSIVYTRLHLNKKVSDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKFEILLCVQDLDDPAVDVCKKLLGKYPSVDAKLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIKVKPDTLTDMANQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKEVLDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMATQVAMQNSGCYSISQFQSRMIRWAKLRINMLPATIICEPISECFVASLIIGWAAHHIFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGPLNFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
What is the function of this protein?
Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi.  Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine).  Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures.  Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction.  They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity).  Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity).
What are the official names of this protein?
Ceramide glucosyltransferase, Glycosylceramide synthase, UDP-glucose ceramide glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: THIM_OLEA2
Sequence: MSEHSFVWDAVQRVRTGAPLVHNITNYVVMNTTANALLAAGASPVMAHAREEVEELAGLCSSLVLNIGTLSKPWIESMFAAGRIAQSRGVPVVLDPVGAGASSLRTWTSLDLLRELNISVLRGNASEILALSGAGSRTKGVDSIHQAADAADAARELAGKFGCVVVVSGAEDLITDGSSDVLVRGGHDMMPRITGMGCTATALVAAHAAVAGSVLDGAAAGMGVMAVAGTMASRKAKGPGSFQMHFIDALYGMQSFDVEAGVEIVR
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: SYE_ACAM1
Sequence: MTVRVRIAPSPTGNLHIGTARTAVFNWLYARHHQGTFILRVEDTDEERSQPEYTENILEGLRWLGMEWDEGPYFQSERLDLYREAIQKLLDQGLAYRCYCTPEELDEMRTAQKERNEAPRYDNRHRNLTAEQEAAFQAEGRQPVIRFKIEDDQTITWKDLVRGPMHWQGRDLGGDMVVARATASGEVGQPLYNLAVVVDDMDLNISHVIRGEDHIANTAKQILLYQAFGGTVPEFAHTPLILNKEGRKLSKRDGVTSISDFQKMGFTAPALANYMTLLGWSPPDATQEIFSLSDAAAQFDFERVNKAGAKFDWDKLDWISSQYLHGLPLAELADALMPYWQAAKYDFDPVADRPWLDQVTALIQPSLVRLKDVVEMTKFLFTRELTWSEDAQKQLSQESVAVALQGVIDPLAAAAESEFSAEIAKSFINSTVKANKLKKGLVMRSLRAALTGDMKGPDLMESWLLLHQRGEDLKRLQQALEIASA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPB1_SCHPO
Sequence: MGKSQKKTAKGRLDKWYKLAKEQGYRSRAAFKLVQLNQKYSFLEKAKVIIDLCAAPGGWLQVASKTCKPGSLIVGVDLAPIKPIPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGAPNVGSAWLQDAYGQAQLVLMSMKLACEFLVAGGTFVTKVFRSRDYNNLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCRGYKAPKKLDPRFTDPRTVFEEVQEPVTNVDAKVFHPEKRKRSREGYADDDYTLHKTVLASEFVTANDPIQILGTSAEIVFPKDDEECQRLYNLDVTTEEILLCCSDLQVLGKKEFRDILRWRLKIRDEMGIGKKVEDEQKTVVEEIPEMDEEERLDQELQDLSEAERVKLKRERRKANQRKQREIVRMQMGMLAPMDIGLEHEAMGEDSLFGLATAEKHGLKELENGTLPVTESVDEEVSTDNEVEYDSDDERDRLEADLDSMYSDYTKRKAESDVKYRVKKARGDLDDEEWNGIDNGTESDDSQIAETNFATPDKDRLTTSLLDKGSTKDGLSRKARMFFDQDIFDGIEDADADVEIMSMNRAAIKKREAELASQNNDDGSKGDQSEDSNDHIEVVPVASAHDEDDDWNSDSDNDENNVEIVTAEAMTLAQDIASRRKSKADLIDEGYNRWSFQSKEGLPDWFLDEETTVNKPNKPITKEAVLALREKMKALNARPIKKVLEAQGRKKMRTIKRLQRVAKKAEGISESGDMTESEKAKEISRLVSRATKSKPKAKPTLVVAKGPNKGLKSRPKGVKGKYKMVDSRMKKDLRAQKRLAKKGRR
What is the function of this protein?
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
AdoMet-dependent rRNA methyltransferase spb1, 2'-O-ribose RNA methyltransferase, S-adenosyl-L-methionine-dependent methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ARGC2_LACPL
Sequence: MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFDATAIMRDNAIVFFATSAGITRQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQQQLVEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMTTIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQNFNRYFDFAVTAGLPTLPVFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase 2, AGPR 2, N-acetyl-glutamate semialdehyde dehydrogenase 2, NAGSA dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTRA_LACLA
Sequence: MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNSQSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAVLKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSGGALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLETSSPSSSN
What is the function of this protein?
Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein.  It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth.
What are the official names of this protein?
Serine protease Do-like HtrA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CLPB2_STRAW
Sequence: MDMNRLTQKSQEALQEAQTAAGRMGHTEVDGEHLLLALLDQEDGLIPRLLQQAGTEPKELRAAVREELSHRPKATGPGAAPGQVFVTQRLARLLDAAEREAKRLKDEYVSVEHLLLALAEESSSTAAGLLLKQAGITRDSFLSALTQVRGNQRVTSANPEVAYEALEKYGRDLVLEARSGRLDPVIGRDAEIRRVTQILSRKTKNNPVLIGDPGVGKTAIVEGLAQRIVRGDVPEGLRDKTVFALDMGSLVAGAKYRGEFEERLKAVLSEVKAAEGRILLFVDELHTVVGAGAAEGAMDAGNMLKPMLARGELHMIGATTLDEYRKHIEKDAALERRFQQVLVDEPSVEDTISILRGLRERLEVFHGVKIQDTALVSAATLSHRYITDRFLPDKAIDLVDEACARLRTEIDSMPAELDEITRRVTRLEIEEAALSKESDPASKTRLEELRRELADLRGEADAKHAQWEAERQAIRRVQELRQELEQVRHEAEEAERAYDLNRAAELRYGRLQDLERRLAAEEEQLAAKQGENRLLREVVTEEEIAEIVAAWTGIPVARLQEGEREKLLRLDEILRERVIGQDEAVKLVTDAIIRARSGIRDPRRPIGSFIFLGPTGVGKTELAKTLARTLFDSEENMVRLDMSEYQERHTVSRLMGAPPGYVGYEEGGQLTEAVRRKPYSVVLFDEIEKAHTDVFNTLLQILDDGRITDAQGRTVDFRNTVIIMTSNIGSEHLLDGATAEGEIKPDARALVMGELRGHFRPEFLNRVDDIVLFKPLGERQIERIVELQFDELRQRLAERRITVELTDAGREVIAHQGYDPVYGARPLRRYISHEVETLVGRALLRGDVQDGATVRVDAEHGELVVTYDQPEDVKGAWAA
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB 2.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_BURPS
Sequence: MSHASPDAARSRIVLASNNPGKLREFAALFSTAGIDIVPQGELGVSEADEPHATFVENALAKARHASRATGLPAVADDSGLCVPALLGAPGVYSARYAQRAGREKSDAANNAYLVEQLREVADRRAYYYCVLALVRHADDPEPLIAEGRWAGEIVDAPRGAHGFGYDPHFFVPALGATAAELDPAAKNAASHRALALKALVARLGEIR
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RLME_BORBU
Sequence: MDDEYSKKAKREGYLARSVYKLIEINEKFSLFSSGNVLDIGASPGSFSQYAYKKLKRGILVSVDINDIGLRYDDNFYFIKGDIFLDDTVFKINTFKPYSLVISDVAPKTTGNRLVDTSNSFNLSMRIIDLSLEVLLKKGNLLVKVFQGGDEMQIFKKFEKYFKFVKKIRPKAVRKNSFEIYFLGKSFGK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.