PharMolix/UniProtQA huggingface dataset:
Protein: KTHY_LACPL
Sequence: MLTGKLVTFEGPDGAGKTSALNAIVAKLQPQLGDRLVVTREPGGNQISEAIRKIILDRHNTAMDDRTEALLYAAARRQHIVQTIQPALQNDQLVLCDRYIDSSVAYQGAGRGIGEQAVYDMNQFATAGLTADLTLYFDVDAAVGLNRIQQHRQNEINRLDVEALSFHHRVQAAYLRLLADHPDRIKRVDASQPLDQVVTQALEIMASQLPTYVASKGGEDQ
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: EX7S_CLOB6
Sequence: MGRKKESFENMLEKLETIVDSMDNGEITLEDSMKSYEEGIKLCNKLYKVLKDAEGKIKILEDNKEEDFENS
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PSEA6
Sequence: MARIAGINIPEHKHTVIALTAIFGVGSTRAQSICEAAGVAETTKIKDLDEAQIDKLRDEVAKFTVEGDLRREVSMSIKRLMDLGCFRGIRHRRSLPLRGQRTKTNARTRKGPRKAIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: OTU7B_MOUSE
Sequence: MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDVIQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSMDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALRRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGSNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKESAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASIILSLEVKLHLLHSYMNVKWIPLSSDSQAPLAQPESPTASAGDEPRSTPESGESDKESVGSSSLGNEGSRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNTLKSWKGGKEEAAGDGPVSEKPPSESVGNGGSKYSQEVMQSLSTMRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQKEVERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPAEPKAMAFSTAYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPGRPYPHQDNIPALEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQTKCKQPNCSFYGHPETNNLCSCCYREELRRREREPGGELLAHRF
What is the function of this protein?
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses.  In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (PubMed:23334419).  Negatively regulates mucosal immunity against infections (PubMed:23334419).  Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241).  Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (PubMed:26903241).  Mediates deubiquitination of EGFR (By similarity).  Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains.  Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure.  Hydrolyzes both linear and branched forms of polyubiquitin (By similarity).
What are the official names of this protein?
OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne.
What is the protein family that this protein belongs to?
Belongs to the peptidase C64 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
Protein: RL29_PARXL
Sequence: MKASELHQKDQAALNKELSDLLKAQFGLRMQLATQQLTNTSQLKKVRRDIARVRTVLTEKANQK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: LPX1_YEAST
Sequence: MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTLEERAVMFDRAFDSFKNEALVKTTKQKL
What is the function of this protein?
Has acyl esterase, lipase and phospholipase A activity.
What are the official names of this protein?
Peroxisomal membrane protein LPX1, Lipase of peroxisomes protein 1.
What are the subcellular locations of this protein?
Peroxisome matrix. Note=Peroxisomal import is dependent on the peroxisomal targeting signal type 1 (PTS1) receptor PEX5 and on self-interaction.
Protein: URE2_PICGU
Sequence: MSGAHTISHLSAGLKSVNIGDQQQNEANLNLLQQQLENEATSQTQQSRITQFFAQQPSDGYTLFSHRSAPNGFKVAIILSELELPFNTIFLDFNHGEQRAPEFVTINPNARVPALIDHFNDNTSIWESGAIILYLVSKYLRDNGECALWSDNIVEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRYFDYPVWLVGDRATVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKYMMRRPAVIRALRGD
What is the function of this protein?
Plays an important role in the cellular response to the nitrogen source.  URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase.  URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
What are the official names of this protein?
Protein URE2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: RL15_STRCO
Sequence: MAENNPLKIHNLRPAPGAKTAKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPFKTEFQVVNLDKLAALYPEGGEVTVEGLVAKGAVRKNSLVKVLGQGEISVALQVTVDAVSGSAKEKITAAGGTVTELV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MNMG_RHIL3
Sequence: MTDNVFDVIVIGGGHAGSEAASAAARLGAKTALITHRRDTIGVMSCNPAIGGLGKGHLVREIDAMDGLMGRVADVAGIQFRMLNKKKGAAVRGPRTQADRKLYRLAMLAAIEATPDLDIIEGDAFDLDVVDGCVAGVIMKDDRTLKAPAVVLTTGTFLRGLIHIGSEKTPAGRVGEAPSIGLSATLARLGLRLGRLKTGTPARLDGKTIDWQSIGRQGADEELIPFSFMTDTITTRQIECGVTRTTEATHRIIVDNIMRSAMYSGQIEGVGPRYCPSIEDKLVKFGERDGHQVFLEPEGLDDDTVYPNGISTSLPAEVQADFIKTIPGLEAARILQPGYAIEYDHVDPRELTPSLEVKRLRGLFLAGQINGTTGYEEAAAQGLAAGLNAALRSSDSDPFHFSRTSSYIGVMIDDLTSRGVTEPYRMFTSRAEYRLSLRADNADMRLTPLAMRVGCVSDARVRRFTSYQAEIETCRALLQSLAVTPNEARRAGLNINLDGQRRTAYDLLSYPNYSFAALSDVWPEKLGMIGPKVAEALEIEAGYSVYLDRQASAIADQQRDEERQIPLDFNYDALAGLSNELKVKLGTARPFNIAQAAIVEGMTPAAIALLLVHLRRLSSAERNSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 289L_IIV6
Sequence: MDALINLKDCKEYMTITFCNQEHQIKLAGTVDTPYFCGKDVCKVLGYKDIKDALKKHVDREDKLPLSEIKKVGGTAPPTFLGQTYAYLSHNDGRAVYISEGGLYSLIMSSEAPFAKDFRRLVCNVILPSIRKFGSYSIEQQLSSAMEQLALKDKSEQELQFQLKQEREEKENAYIKLRSETKRLKQQIKRTLEFNQATKQIEPLEYIYICTTEYYQQQHKFKVGGVQTFDLLKSRLTQYNSGESDSEAHFFIYIRKTVNYRSIEHAIKGLLSGFRENQSNELYIMHYDWLVKFVDAIMDGNAEFALLVNNNREQIAEDTINKEPTIVPPIQLEQIMYHRAGDNPRDLTSILDSETKRAIQDAIDSFEPYNNTVKRREFEEHLLKQSPNIKLEGKKRNAWDIARAMGSTKNPMWRYKY
What are the official names of this protein?
Putative Bro-N domain-containing protein 289L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 201R/289L family.
Protein: DEGP6_ARATH
Sequence: MLFRSVHHIVARFSNSTSTPIHRFFYSPSLLRRRSSFNASLISRCCSSVSDVDVARDAVVKIFSFSREPNVVQPWQTTEKEYSSSGFAISGRRILTNAHVVGDHLYLQVRKHGSPTKYKAEVKAFRYGCDLAILGIDSEEFWEDINPLELGGIPFIGETVYALGYPRGGDTISVTKGIVTRVEPQKYSHSSIKMYVYTSGGSTNKFYSGQINKKIYDGR
What is the function of this protein?
Putative serine protease.
What are the official names of this protein?
Putative protease Do-like 6, chloroplastic, DEGP protease 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PPNP_SHIDS
Sequence: MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVINGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: DDLA_BACCR
Sequence: MLLWAGYASEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMDLIEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGSNMLSSSICMDKNISKKILRYEGVETPDWIELTKMEDLNLDELDKLGFPLVVKPNSGGSSVGVKIVYNKNELISMLETVFEWDSEVVIEKYIKGDEITCSILDGKQLPIVSIRHAAEFFDYNAKYDDTSTVEEVIELPAQIKERVNKASLTCYKALKCSVYARVDMMVKDGIPYVMEINTLPGMTQSSLLPKSAEAAGISYSKLLDMIIETSLKVRNEEGF
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase A, D-Ala-D-Ala ligase A, D-alanylalanine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCTP_LUMRU
Sequence: MIIFKDVFPGVELFSDSFPVSLVNETVYKVKGKLRTDTFAIDDKAIGGNASAEGGEEGTDAASKQGVDIVMNSRLVEYALSKKDYMTHIKSYMKSVKDKLQETKPADSELFQKNVQPFIKEVLNDFKEYQLFCGESMGPEGMLALMKWDGETPYMFFFKHGLDEEKV
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAR1B_BRACM
Sequence: MFLFDWFYGILASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFSESKKELDALLSDDALATVPFLILGNKIDNPYAASEDELRYHLGLTNFTTGKGKVTTAGGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIN
What is the function of this protein?
Involved in transport from the endoplasmic reticulum to the Golgi apparatus.
What are the official names of this protein?
GTP-binding protein SAR1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus.
Protein: YDCS_BACSU
Sequence: MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAERFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE
What are the official names of this protein?
Uncharacterized protein YdcS.
Protein: ILVC_BART1
Sequence: MRVYYDRDADMNLIKGKKVAIVGYGSQGRAHALNLKDSGVQNVQIALRSGSETVKKATADGFEVVSVAEAAKWADLIMMATPDELQADIYKEHIHDHLRDGAAVAFAHGLSIHFGLIEPKKTVDVVMIAPKGPGHTVRHEYQRGCGVPCLIAVAQDASGHAHSVALSYACGLGGGRAGVIETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTQAGYAPEMAYFECLHEVKLIVDLMYEGGISNMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAAHFKSMRRLNDNHPIEEVGKKLRSMMPWIKSNALVDKERN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ARP42_SCHPO
Sequence: MEEIPSLVIDPGSCWTRFGYAGEESPMTILPSYYGVRSDVTGRNKYVVDELQIHAPIPGMEVKNGKSNGIIQDWESTLYTWERGLKEKLQVNPTEYAMMITEPSWNPQSVRQQIMEAAFEQLHVPAFYLTKQAVCVAFANSKSTALIVDIGSDNASVTPVVDGLIIRKGIFKQSLAGDFLNANIEQLFNTMNIEFPPHYRIARKSVAIQQSGNMANGSADAVKPAVLYPPIQDLTSSYEIFQKRRVIEEWKESVLDVLDTPFDEAKASSRNPKPFEFPDGVTHKFGQERFRISEILFNPSFSASRSAETTPPQGSVGLHELVYQSILACDSELRSPLLNNIVVTGGTSLIPGLSERLQAEVQRLATGSRINVHTAETASATSNAVWFGGSILASLDNFQHLWVSKQEYDEVGVDRALFVEKRCK
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  Controls particularly membrane and organelle development genes.  Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
SWI/SNF and RSC complexes subunit arp42, Actin-related protein 42, Chromatin structure-remodeling complex subunit arp42.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYSZ_MANHA
Sequence: LNFTFGALVSLFTMIPFVNLVVMPVAVCGATALWVKEYRNFFLNNQTGEFSKADYTFTKVNSTSLSTETRTGEVSPNVRNGDIRKQ
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ITT1_YEAST
Sequence: MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHGYNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCYGRLFEGMPGTET
What is the function of this protein?
Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
What are the official names of this protein?
Translation termination inhibitor protein ITT1.
What is the protein family that this protein belongs to?
Belongs to the RBR family.
Protein: COAE_SYNAS
Sequence: MPEGVPCGRRGAMLNVGLTGSISCGKSTVARMLEGKGAFIIDFDRLAHDVEEPDKPAWRGIVDTFGPDVLREDRTIDRARLGTLVFADRRKLEKLNEIVHPAVFEAWRRSVEEIRGVRPDAIVVSDFPLLIELGKQNDYDVILLVYIPPQEQIRRLILRNGYSPEEAIQRVNSQMSIEDKIDFADIIVNNAGPREQTQAQIDKIWTQLLKKERLQRKSAASSFQTGTIHKEREVG
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T23O_RAT
Sequence: MSGCPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGDYLQLEKILNAQELQSEIKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVMTRMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFEGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPHGFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGSKAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIHKFLYTAEYSDSSYFSSDESD
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: BETA_ECOSE
Sequence: MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: CSK22_CHICK
Sequence: MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIINLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSMGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIELDPHFNDILGQHSRKRWENFIHSENRHLVSPEVLDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSSENAVLSSGLTTAR
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  The alpha and alpha' chains contain the catalytic site.  Participates in Wnt signaling (By similarity).
What are the official names of this protein?
Casein kinase II subunit alpha', CK II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein: ATPA_BRUA4
Sequence: MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGADRDIKEGDIVKRTGAIVDVPVGPGLLGRVVDALGNPIDGKGPIVATERRRVDVKAPGIIPRKSVHEPMSTGLKAVDALIPVGRGQRELVIGDRQTGKTAIILDTFLNQKPIHDNGPDSEKLYCVYVAIGQKRSTVAQFVKVLEERGALEYSIVIAATASDPAPMQYLAPFAGCAMGEYFRDNSMHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDENGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSSAQVKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIAVNQVGKFEAGLLSSLRTEHKDVLDAIRDEKALTDNIKAKLKAAVDAFAKSFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SCX1A_TITFA
Sequence: MKGMILFISCLLLIGIVVECKEGYLMDHEGCKLSCFIRPSGYCGSECKIKKGSSGYCAWPACYCYGLPNWVKVWERATNRCGKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  The toxin induces a leftward shift, on all channels tested (including Blattella germanica and Varroa destructor Nav1), displacing a change in voltage dependence activation to more hyperpolarized potentials (PubMed:30131471).  In addition, the toxin mostly inhibits peak current of hNav1. 4/SCN4A (53% inhibition of peak current at 100 nM) and hNav1. 5/SCN5A (71% inhibition) (PubMed:30131471).
What are the official names of this protein?
Beta-toxin Tf1a.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BUL2_YEAST
Sequence: MTFTFSTSSRKNGRPPLKSVSTEDNIHLLRKRRQQQLSSNSTDNSLHPNSGQTPRASDSQDDDIRSASTTNLDRLRQEREENSLEMDCTQSRLSHRANMLVDVLPSFEMYNALHRHIPQGNVDPDRHDFPPSYQEVRTQRMTILPSNDNSVERSQLTAVPGSENACNNATAHSLTNLHPLQTQHLTINSTRSGGQSLHSSSDTNISQIPFEDDLNDSDNIFIDKLYTLPKLSTPIEIDIRITKTASIPHERPEEQSILKEYTSGDIIHGYCLIENRSSQPLKFEMFYVTLEAYISVIDRQKGKRTLKRFLRMVDLSASWSYTNITPSTGINIVPGERDFDDAIIGLSNSRELKPNTKYKKFFMFKLPTQLLDVTCKQEQFSHCLLPPSFGIDKYKNNCKYSGIKVNSVLGCGHLGTKGSPILTLDMADDNLSINYTIDAKIVGKDKRTSKLNIMKEKEYNLRVMPFPFAGVTNQQNEKTCLRQLKNLESLIEDRFEALNKIFKKLELNEAISNVDIHDTDISGTLDGNEDLDSDEILRRKLDQLHINNRIDDTASQSPSYDSKNMAPKENLVETELRYKFKNKNKSNSSLFSHFLSSSETGSSSTGPHVYNSGLIVLSVKKPQSTLPYWSPSLLRKTNKFEAKSEQEKENWQRLMGMLPEGVKTPLTKLDVHLTCIQSNNSAGHKPPEISSVTTEFVVITAKSDNSIPIKFCTELLMNENRLNKLKTKFLTYQKKVHEYRKKFEENHAKLNELYNRNRDHFTPKELLFTNFISDQINNDIDSLAGLKVNIIDLHDIFKKQIHTFEEENEDIISKKGSSNPPSASSSNNNFLQATFSNGASTATKFTQQIVHEWEKVKPLQYKRDVTVNLKLNPNIKETLVPNLETCLCCRFYCVRVNIKFDNHLGSMKVDIPVDVKKLQI
What is the function of this protein?
Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1.  The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.
What are the official names of this protein?
Ubiquitin ligase-binding protein BUL2.
What is the protein family that this protein belongs to?
Belongs to the BUL1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC9B_MOUSE
Sequence: MQRGALSPVLMLSAAPEPPPRPPPALSPPGPGSAPRHGSARSGPAPEPSGGLAAALDSSLRAAVAFKAEGQRCYREKKFREAIGKYHRALLQLKAAQGARPGGLPTPSPGPTTSPGPARLSEEQRRLVENTEVECYDSLTACLLQSELVNYERVREYCLKVLEKQQGNFKATYRAGIAFYHLGDYARALRYLQEARSREPTDTNVLRYIQLTQLKMNRCSLQREDSDGGTGGPARNVVG
What are the official names of this protein?
Tetratricopeptide repeat protein 9B, TPR repeat protein 9B.
What is the protein family that this protein belongs to?
Belongs to the TTC9 family.
Protein: CUEDB_CONCL
Sequence: MKLCVVIVLLMLAMPFNGGEASRFFNQHARSQRSGMKTRGIWCDPPCPEGETCRGGECSDEFNGDMGR
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal14.13b, Conotoxin Cal14.1b.
What are the subcellular locations of this protein?
Secreted.