PharMolix/UniProtQA huggingface dataset:
Protein: SP0A_MOOTA
Sequence: MEAIKVLIADDNREFCEVLEEYFNEQEDFVLSGVAHNGQETLELIQEQEPDIVILDIIMPHLDGIGVLEKLQVLNFEPRPKIVILTALGQESMTMRSVELGADYYILKPFDLEVLGNRLRQLANGHPLPTAPSQVSRAGRNMDVEVTKIIHQMGVPAHIKGYQYLREAILMVIDDVSLLGAVTKELYPLIARKYMTTPSRVERAIRHAIELAWDRGNVEMMNKFFGYTINVERGKPTNSEFIAMVADKLRIGAKIN
What is the function of this protein?
May play the central regulatory role in sporulation.  It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress.  Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process (By similarity).
What are the official names of this protein?
Stage 0 sporulation protein A homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA_DESHD
Sequence: MHEMSLMGGVFEAIEATLAHHHVKKVLLVKLKIGQLTNAEPDALQMAFAAFAQGTVCEGAELQIEMLPVKGRCRSCSEEFMVPGLIFACPVCQHLGIDITQGEELLLESLEVEE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: VQ19_ARATH
Sequence: MEISTNPPSSSSSSVSSSIINGSLHHHIITRSDHYPTTFVQADSSSFKQVVQMLTGSSSPRSPDSPRPPTTPSGKGNFVIPPIKTAQPKKHSGNKLYERRSHGGFNNNLKNSLMINTLMIGGGGAGSPRFSPRNQEILSPSCLDFPKLALNSPVTPLKQGTNGNEGDPFDKMSPLSEEERGIADKGYYLHRSPISTPRDSEPQLLPLFPVTSPRLSPEM
What is the function of this protein?
May modulate WRKY transcription factor activities.
What are the official names of this protein?
VQ motif-containing protein 19, AtVQ19, MPK3/6-targeted VQ-motif-containing protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARLY_STRGG
Sequence: MSSNNGDVRLWGARFADGPAEALAKLSASVHFDWRLAPYDIAGSRAHARVLSKAGLLSEDELTRMLAGLDQLEADVADGSFTGTIADEDVHTALERGLLERLGADLGGKLRAGRSRNDQIATLFRMYLRDHARTIGGLIADLQSALVGLAEAHADVAMPGRTHLQHAQPVLFAHHVLAHVQSLSRDAERLRQWDERTAVSPYGSGALAGSSLGLDPQAVAADLGFERGSVANSIDGTASRDFVAEFAFITAMIGVNLSRIAEEVIIWNTKEFSFVTLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSCDQLEVLLPAFTGMMATLTVNRERMEELAPAGFSLATDIAEWLVKQGVPFRVAHEVAGACVKECERAGIELDQLTDEQFAEISEHLTPEVRTVLNVRGALASRDGRGGTAPSAVAVQLAEVKEDLAAQHAWATARP
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRQ1_YEAST
Sequence: MEEGPIKKKLKSAGQGSGKTDAFRNFEQFFFRLNTLYTFLICRKHVVPTFKTLCGPIETALKRTVTKEDLAMVMALMPRECVFKYIDENQIYTETKIFDFNNGGFQQKENDIFELKDVDDQNQTQKSTQLLIFEFIDGTMQRSWSASDRFSQIKIPTYTTEEMKKMISKREALFKSRLREFILEKEKANLDPFSELTNLAQKYIPRERDYEDPIEAMMKAKQESNEMSIPNYSNNSVITTIPQMIEKLKSTEFYASQIKHCFTIPSRTAKYKGLCFELAPEVYQGMEHENFYSHQADAINSLHQGENVIITTSTSSGKSLIYQLAAIDLLLKDPESTFMYIFPTKALAQDQKRAFKVILSKIPELKNAVVDTYDGDTEPEERAYIRKNARVIFTNPDMIHTSILPNHANWRHFLYHLKLVVVDELHIYKGLFGSHVALVMRRLLRLCHCFYENSGLQFISCSATLKSPVQHMKDMFGINEVTLIHEDGSPTGAKHLVVWNPPILPQHERKRENFIRESAKILVQLILNNVRTIAFCYVRRVCELLMKEVRNIFIETGREDLVTEVMSYRGGYSASDRRKIEREMFHGNLKAVISTNALELGIDIGGLDAVLMCGFPLSMANFHQQSGRAGRRNNDSLTLVVASDSPVDQHYVAHPESLLEVNNFESYQDLVLDFNNILILEGHIQCAAFELPINFERDKQYFTESHLRKICVERLHHNQDGYHASNRFLPWPSKCVSLRGGEEDQFAVVDITNGRNIIIEEIEASRTSFTLYDGGIFIHQGYPYLVKEFNPDERYAKVQRVDVDWVTNQRDFTDVDPQEIELIRSLRNSDVPVYFGKIKTTIIVFGFFKVDKYKRIIDAIETHNPPVIINSKGLWIDMPKYALEICQKKQLNVAGAIHGAQHAIMGMLPRFIVAGVDEIQTECKAPEKEFAERQTKRKRPARLIFYDSKGGKYGSGLCVKAFEHIDDIIESSLRRIEECPCSDGCPDCVAASFCKENSLVLSKPGAQVVLHCILGHSEDSFIDLIKDGPEPNMPEIKVETVIPVSEHVNFSDDFKIIDVRRATKDDTHTNEIIKKEI
What is the function of this protein?
Helicase with 3'-5' helicase activity involved in genome stability (PubMed:23456718, PubMed:24440721, PubMed:24700328).  Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed:24440721, PubMed:24682993).  Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (PubMed:23026052).  Activity is significantly stimulated by a preexisting fork structure (PubMed:24682993).  Shows both processive helicase and DNA strand annealing activities (PubMed:24682993).  Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding (PubMed:24440721).
What are the official names of this protein?
ATP-dependent helicase HRQ1, Homologous to recQ protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. HRQ1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURD_GEODF
Sequence: MEIKGKKILVVGLARTGVAVARFLASRGAKVTVTDMKEESELADYLLQLEDLDLNLELGRHDKHTFLMSDLIVVSPGVPMDISPLLMAKAQRRVVISEIELAAAFIKAPMVAITGTNGKTTTTTLAGEIFKACGVETFVGGNIGNPLIELVTSGNDVAQVVVELSSFQLEGIQRFRPKVAVLLNITEDHLDRYASYQDYIDAKLRIFENQTVDDFAVLNVDDPLVAACAATVKSRVFPFSQRKELAEGIFCSKGIIVYRWQGSELRFDTAAFKLKGVHNIENIMAALASTLLSGADPIKAGRAVESFKGLRHRMEFIREVGGVAYYEDSKGTNVGSVVKSLESFDKGITLIAGGKDKGGSYAPLADLVRERVKHLILIGEAKERIEAELGNLTDTHKAATLEDAVAIAHRLAKAGEVVLFSPACSSFDMFKDYAERAERFNAAVRALAGGDCR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURQ_LATSS
Sequence: MKFAVLVFPGSNCDADLYHAIVDVCHEEAAYVSYTATSLAGFDAVLIPGGFSYDDYLRSGAIAKLAPIMTAVVAFAKAGKPVLGICNGFQILTEAGLLPGALLPNRQTHFICETVTLQVENNDTRFTNQYAKGATIALPIAHGEGNYYCDPETLAQLHANHQIAFTYTTDVNGSLDNIAGITNEAGNVLGMMPHPERAVEVLLGSADGLGVFQSILTTLKSGVVTHGE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURE_BRUSU
Sequence: MSVDVAIIMGSQSDWETMRHAAHTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKVIIAGAGGAAHLPGMAAAMTPLPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSNEA
What is the function of this protein?
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
What are the official names of this protein?
N5-carboxyaminoimidazole ribonucleotide mutase, N5-CAIR mutase, 5-(carboxyamino)imidazole ribonucleotide mutase.
What is the protein family that this protein belongs to?
Belongs to the AIR carboxylase family. Class I subfamily.
Protein: FUCM_SALTY
Sequence: MLKTISPLISPTLLKVLAEMGHGDEIIFSDAHFPAHSLGPQVIRADGLSVSDLLRAIIPLFELDSYAPPLVMMAAVEGDTLDPNVEARYRDALSLEAPCPDIVRIDRYAFYERAQKAFAIVITGECAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_CANPA
Sequence: MFLISGISSILAIGLLSPVQSIVCLIVLFVSAAISLYSNGFVLMGILYVLIYVGAIAILFLFILSLLNIEYNYKGTIHPLIFTILIICLIPLDLSYETYGIVENVNIAYPFNSLLDWDLELTTVGSLLYTEYAIPMILIGLILILSVIGAIAITK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: QUEA_BACC7
Sequence: MDINLFDFHLPEELIAQVPLEERETSRLMVLDRETGDIEHKHFTDILSYLHEGDCLVLNETKVMPARLHGVKEDTGAHIEVLLLKQEEGDKWETLVKPAKRVKEGTVISFGEGKLKATCTGTADQGGRQLEFSYDGIFYEILDELGEMPLPPYIKETLEDRDRYQTVYAKEIGSAAAPTAGLHFTEELLEKLKQKGVELAFITLHVGLGTFRPVSADTIEEHHMHAEYYHMSEETAALLNRVKENGGRIITVGTTSTRTLETIATDHDGKLCAASGWTDIFMYPGYEFKAIDGLITNFHLPKSTLIMLVSAFANRDNVLHAYNEAVKEKYRFFSFGDAMFVASHAKMGNK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESTE_PSEFL
Sequence: MSTFVAKDGTQIYFKDWGSGKPVLFSHGWLLDADMWEYQMEYLSSRGYRTIAFDRRGFGRSDQPWTGNDYDTFADDIAQLIEHLDLKEVTLVGFSMGGGDVARYIARHGSARVAGLVLLGAVTPLFGQKPDYPQGVPLDVFARFKTELLKDRAQFISDFNAPFYGINKGQVVSQGVQTQTLQIALLASLKATVDCVTAFAETDFRPDMAKIDVPTLVIHGDGDQIVPFETTGKVAAELIKGAELKVYKDAPHGFAVTHAQQLNEDLLAFLKR
What is the function of this protein?
Hydrolyzes phenolic esters, such as phenyl acetate, nitrophenyl acetate and naphtyl acetate (PubMed:1368608, PubMed:7704276, PubMed:9571805, PubMed:15803517).  Can act on a wide range of esters, but reaction rate and enantioselectivity differ significantly depending on the substrate (PubMed:1368608, PubMed:9571805).  Shows a preference for esters with small acyl groups (PubMed:15213385).  Also shows low perhydrolase activity, and catalyzes the reversible formation of peroxycarboxylic acids from carboxylic acids and hydrogen peroxide (PubMed:15803517, PubMed:20112920, PubMed:22618813).  In vitro, enzyme-generated peracetic acid oxidizes bromide ion to bromonium, which reacts with monochlorodimedone to form bromochlorodimedone (PubMed:7704276, PubMed:20112920, PubMed:22618813).
What are the official names of this protein?
Arylesterase, Aryl-ester hydrolase, Carboxylic acid perhydrolase, PFE, Putative bromoperoxidase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Bacterial non-heme haloperoxidase / perhydrolase family.
Protein: GBUB_LISM4
Sequence: MPNIPTIPLASWIDKLVDGLTQFEGFFNVITNIIGGIVDAFQWVFDLVPPWLFIILLVFGTFWVNRKGKKWGLIIFEVVGLLLIWNLDFWRDMTQTLTLVLTSSLIALVIGVPLGIWMAKSNIVESIFKPVLDFMQTMPAFVYLIPAVAFFGIGMVPGVVASVIFAMPPTVRMTNLGIRQVSTELVEAADSFGSTPWQKLWKVQLPMAKSTMMAGINQSIMLALSMVVIASMIGAMGLGTRVYFAVGRNDAGGGFVAGIAIVIVAIILDRLTQAFNKKAKSE
What is the function of this protein?
Part of the ABC transporter complex GbuABC involved in glycine betaine uptake.  Responsible for the translocation of the substrate across the membrane.  Involved, with BetL and OpuC, in osmoprotection and cryoprotection of Listeria.  Can also uptake carnitine when carnitine is abundant in the growth medium.
What are the official names of this protein?
Glycine betaine/carnitine transport permease protein GbuB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSAE_PARMW
Sequence: MAISRGAKVRIKRPESYWFNEVGTVASIDTSGIRYPVVVRFEKVNYTGIDGTDGGVNTNNFSEAELELA
What is the function of this protein?
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
What are the official names of this protein?
Photosystem I reaction center subunit IV.
What is the protein family that this protein belongs to?
Belongs to the PsaE family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: LEPA_VIBPA
Sequence: MKHIRNFSIIAHIDHGKSTLSDRLIQVCGGLSDREMAAQVLDSMDLERERGITIKSQSVTLNYTAKDGETYQLNFIDTPGHVDFAYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAADPERVAEEIEEIVGIDAMDATRCSAKTGLGVEDVLENIVSAIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRIKNGSLKKNDKIKVMSTGQAWGVDRLGIFTPKQVDTDVLNTGEVGWVVCGIKDILGAPVGDTLTLAKNGSDKPLPGFKKVKPQVYAGLFPVSSDDYENFRDALGKLSLNDASLFYEPENSAALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVYEVEKTDGELLYVDSPAKLPAINDIEEIREPIARCNILVPSDYLGNVITLCVEKRGLQVDMVYHGNQVAVTYDIPMAEVVLDFFDRLKSTSRGYASLDYNFQRFEASNMVRVDVLLNGDKVDALALITHKDQSQTRGRQLVEKMKEFIPRQMFDIAIQAAIGNHIIARSTVKQLRKNVIAKCYGGDVSRKKKLLKKQKEGKKRMKQIGNVELPQEAFLAILHVGKD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METXS_HYDCU
Sequence: MTDEIGIVTPQKLHVSTPLEMVSGSTLPEYDLAYETYGSLNADKSNAILICHALSGNHHVAGQYEGESTRGWWDGYIGPGKPIDTNRFFVVCSNNLGGCHGSTGPASINPLTGKVYGPDFPIVTCKDWVHSQNTLRQHLEIDAWAAVIGGSMGGMQVLQWTIDFPDQIRHAIVIASAPKLSAQNIAFNEVARRAIMTDPDFHDGRFIEAGTTPKRGLALARMLGHLTYLSDDMMGSKFGRELREGKLNYNFDVEFQVESYLRYQGEKFATKQNFDANTYLLMTKALDYFDPAADFDDDLSKALSGATAKFLIISFTTDWRFSPERSHEIVKALLDNDADISYAEVNSQHGHDAFLLPNDHYEGVFRAYMKRIHAELNHTSLQEGE
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THRCO_CORXX
Sequence: TACTTGPQTISFPAGLIVSLNASVQSSRNESVEVKDSNGNTVSRGSGSSSSGGTFTVINMEPPTFISDGNDYTVELSPQATPGILQTESSRVDNGRLIWQNYAFGANDGGCIVGDRDFNDVFVLITGLVRG
What is the function of this protein?
Binds to fucose and mannose in a calcium-dependent manner (in vitro) (Ref. 2).  Acts as an agonist for human thrombopoietin receptor MPL (in vitro) (PubMed:30978513, Ref. 2).  Binding of sugar-moieties may promote the interaction with human MPL on the cell surface (in vitro) (Ref. 2).  Catalyzes MPL dimerization and activation, and modulates internalization of the receptor (in vitro) (Ref. 2).  Exhibits proliferation activity in murine recombinant Ba/F3 cells expressing human MPL (Ba/F3-huMPL) (in vitro) (PubMed:30978513).  Induces phosphorylation of STAT5 in recombinant Ba/F3-huMPL cells, possibly by stimulating MPL on the cell surface to transduce signals via Jak/STAT signaling pathway (in vitro) (PubMed:30978513, Ref. 2).  Does not aggregate rabbit erythrocytes, indicating absent lectin-like agglutination activity (in vitro) (PubMed:30978513).
What are the official names of this protein?
Thrombocorticin, ThC.
Protein: ACTC_BRALA
Sequence: MDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPVEHGIVTNWDDMEKIWHHTFYNELRIAPEENPLLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDQTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMSTAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESTGVHETTYNSIMKCDIDIRKDLYANTVLSGGTTMFPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GLYA_METPB
Sequence: MSAGTASDTTALNTFFSAQLAETDPEIAKAISQELGRQQHEIELIASENIVSRAVLEAQGSVLTNKYAEGYPGRRYYGGCQFVDIAEELAIDRAKRLFGCGFANVQPNSGSQANQGVFMALMQPGDTFLGLDLAAGGHLTHGAPPNVSGKWFKPVSYTVRREDQRIDMEQVERLAQEHKPKVIIAGGSGYPRHWDFAKFREIADSVGAYFFVDMAHFAGLVAAGLHPSPFPHAHVATTTTHKTLRGPRGGMILTNDEALAKKFNSAIFPGLQGGPLMHVIAAKAVAFGEALKPEFKIYAKQVIDNAKALADTIISGGYDITSGGTDNHLMLVDLQKKGLTGKAAEAALSRADITCNKNGVPFDPQKPTITSGIRLGTPASTTRGFGVAEFKQVGSLIVQVLDGLADKGESGDSTVEAAVKEKVHALTDRFPIYS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMC89_DROME
Sequence: MCDYKVSERAYAKLIFHAAKYPHQAVNGLLLAEKTSKGSQVEIVDAIPLFHQCLYVTPMAEVALMLIDAHAEREGLVIAGYYAAPENFYDNQVDKTPAAKIADKIQENFKNACFVVVDNKLMTLQHDRAAIQVFNCPGDSGARWSKAKFTLSQASDTLEGVSLLLKRGAMRDLVDFDNHLDNPDKNWTNDFLNQPLNDLQKLY
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins.
What are the official names of this protein?
ER membrane protein complex subunit 8/9 homolog.
What is the protein family that this protein belongs to?
Belongs to the EMC8/EMC9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: G1PDH_METM7
Sequence: MIVIPRYTIIKEKASIRIPEILDNLNLKNPLVITGKNTQKYNKDFDFIYYDEIETSDLENLKNYTKDYDSVIGIGGGRPIDIGKLIAHKSKKPFLSVPTTASNDGIASPIVSLTQPSYMTEAPIAIIADTEIIKKSPKKLLSAGMGDIVSNITAVLDWELGKIEKLEKYSDSSGIFSKTIAIELMDYVLNSDLEEYPKKLVKALIGSGISIAIAHSSRPASGSEHLFSHALDNMKEKYGIDTNSLHGEQCGVGTLAIAQIYLEEGKIEVETVEMIKNSLKAVDAPVTAKQLGFDEEILSEALSSAHSLRNRHTILRNGLSKEKAREILEKSEII
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP165_BPPZA
Sequence: MNQKEFQAVLDWMLSHTIIQFHEYNYMLQKSLPFLRR
What are the official names of this protein?
Gene product 16.5, gp16.5, Early protein GP16.5, Protein p16.5.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.5 family.
Protein: SYL_PROM5
Sequence: MIYSENTDEKSNQHTNNLYKPCEIENKWQEIWDKENLYKTDDKSSKKEKFYALSMFPYPSGNLHMGHVRNYVITDLIARFQRFQGKSLLHPMGWDAFGLPAENAAIERGINPNDWTKKNIAHMKSQLKLLGLSVDWDKEFATCDENYYLWTQFLFLELHKSGLVYQKESEVNWDPIDNTVLANEQVDSEGKSWRSGAKVEKKLLTQWFLKITNYTEELLQDLEKLSEWPERVKIMQENWIGKSKGANIIFKINEFENEKIKVFTTRPDTLFGVTYIAISINNPLINKISDNEILSKLENLKIYLKKNQDKDQKKIGIPTNLKAINPINSNEIPIWIASYVLDEYGTGAVMGVPAHDQRDFEFAKINFIDIKQVIIKDKDNDKSTFKLKNAFTDNGFLINSNNFNGLCNNDAKKQILEQGKINGWAEEEIHYRLRDWLISRQRYWGCPIPIIKCNNCGSIPVNKKNLPVKLPKEIEISSNKINSLGSYKDWVKTTCPKCGNLASRETDTMDTFMCSSWYFLRYPSSKCKTKPFEKDNVNKWLPVDQYVGGVEHAILHLLYARFLTKALRDNNLFDIDEPFKKLLTQGMVQAAAYKNTKTGKYISPKDIKDFNNPTDPNDDSKLEVLFEKMSKSKYNGIDPESVIKKYGADTARMFILFKAPPEKDLEWGDSDVEGQYRFLCRIWKLFLDYRNNESWDNQKNYNREKENSLTKSINIAIKEISNDIKNNQFNTAISELMKFYNSLSSSMIYVNKDLRKDAFKKFCILLAPFAPHIAEEIWNLIGYQKSVHLERWPIFNEDALKEDCYELVIQINGKVRDKINVGIDISEDQIKQKTLTRPNVRKWIDQKTIRKIIIVKGKIMNIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_CHLAD
Sequence: MIAVINYGAGNLPNVVRALQRVGAKLTITDDPHVIRSAHAVVLPGVGATADTMASLQQLGIADVLPEVIAAGTPFLGICVGMQVLLSASEEFGPHPCLDIVRGTVRRLPDSAGKIPQIGWNQLRIMPNFSDHPLFVGIPNGADVYFVHSYYCDVIEETIVAARTEYGIAFPSVIIRDRLAAVQFHPEKSGDYGLRLLANFVAWSNASPARG
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_SPHYA
Sequence: IEAMAHHIVPARDVLYLGRGTDYPLALEGALKLKEISYIHAEGYAAGEMKHGPIALIDELVPVICIAPSGPLFEKTVSNMQEVQARGGKVVLISAYDGVQAAGEGCLATITMPKVHPLIAPMVYAVPVQLLAYHVAVLKGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.