PharMolix/UniProtQA huggingface dataset:
Protein: TYRP_ECOLI
Sequence: MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQHVPADTGLGTLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSATAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVMLVLLLPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSIDSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRSNTVGGRLQTGAITFLPPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSRKHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLPEVG
What is the function of this protein?
Transports tyrosine across the cytoplasmic membrane (PubMed:6090409).  The transport system is energized by the proton motive force (PubMed:6090409).
What are the official names of this protein?
Tyrosine-specific transport system, Tyrosine permease, Tyrosine:H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD_SHEB8
Sequence: MQPFTTHTGLAVMIDSTNIDTDQIIPKQFLSKVTRDGFGVHLFHDWRYLDDAGDQPNPEFSLNQSRYKGASILLAQENFGCGSSREHAPWALVDFGLRAIIAPSFADIFYGNSINNGLLPVALTHAQVRQLMDEVAAEAGAQITVDLTSCKVISPSGAEFSFTLAESARHKLLNGLDAIGLTLSHAAQISQYETQIQGWRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: BPT_XANP2
Sequence: MSEHPRDTPQFYLTAPSPCPYLPGREERKVFTHLVGDKAASLNDVLTQGGFRRSQSIAYRPACEGCKACVSVRICVDDFTPGRSFRRVQADNSDLIGQIKPATPTSEQYALFRSYVTGRHGTGGMADMSVLDYAMMVEDTHVHTRLVEYRKRGPDSRIIPRGTGDLMAVALTDVLTDGLSMVYSFYNPQVHDRSLGTFLILDHITRARQMGLPYVYLGYWVQGSRKMDYKRRYLPQERLTPHGWERVEK
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB29B_ARATH
Sequence: MSFLLLTPPPCLLIPPPPLSHRRSSSLFLKHPFQPSPRPLSFCKPSALRLRANTTVNSLKALETIKPYLQSESKTVLLGWLCSCVSVVSLSQIVPRLGSFTSNLNANAASLTKLKGECLVLAGLVLAKVVAYYLQQAFLWEAALNTVYKIRVFAYRRVLERELEFFEGGNGISSGDIAYRITAEASEVADTIYALLNTVVPSAIQISVMTAHMIVASPALTLVSAMVIPSVALLIAYLGDRLRKISRKAQIASAQLSTYLNEVLPAILFVKANNAEISESVRFQRFARADLDERFKKKKMKSLIPQIVQVMYLGSLSIFCVGAVILAGSSLSSSAIVSFVASLAFLIDPVQDLGKAYNELKQGEPAIERLFDLTSLESKVIERPEAIQLEKVAGEVELCDISFKYDENMLPVLDGLNLHIKAGETVALVGPSGGGKTTLIKLLLRLYEPSSGSIIIDKIDIKDIKLESLRKHVGLVSQDTTLFSGTIADNIGYRDLTTGIDMKRVELAAKTANADEFIRNLPEGYNTGVGPRGSSLSGGQKQRLAIARALYQKSSILILDEATSALDSLSELLVREALERVMQDHTVIVIAHRLETVMMAQRVFLVERGKLKELNRSSLLSTHKDSLTSAGLVI
What are the official names of this protein?
ABC transporter B family member 29, chloroplastic, ABC transporter ABCB.29, AtABCB29, ABC2 homolog 12.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: Y56_SIRV1
Sequence: MKKEIQVQGVRYYVESEDDLVSVAHELAKMGYTVQQIANALGVSERKVRRYLESC
What are the official names of this protein?
Uncharacterized protein 56.
Protein: PSA2_RAT
Sequence: MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-2, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity).
Protein: ODPX_SCHPO
Sequence: MLKHYIHQCVKASSCKHSLSVKQRYFHCSALNGVASMFRMPALSPTMEEGNITKWHFKEGDSFKSGDILLEVETDKATMDVEVQDNGILAKVLIEKGSNIPVGKNIAIVADAEDNLKDLELPKDEASSEEQSFSSSKEEVKPIVQDRETKSNVEHKSTSQANDAVNKSFLPSVSYLIHQYKIENPWSIPATGPHGRLLKGDVLAHVGKIDKGVPSSLQKFVRNLEVLDFSGVEPKKPSYTEDSVPVRKSTMIETLKTVPMKDEYITFERSISLEKLKSLLAKRKEKDAFGIDEVVSAMIGDALSISELSKVEPNSIESAYDLLLGAPIVKLKSSVSNFQPKLFPKNNNTKDLHKYIRDSMIGLPSNLSDYVKLNFSSVTKSSSNNVEFLDDVYDMLLGSNSDSIDSRINRHEEPSTTEDLTLTLSIKDNISKSRAIKFVDCLKSNFENPEFVLSRW
What is the function of this protein?
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes.  This specific binding is essential for a functional PDH complex (By similarity).
What are the official names of this protein?
Probable pyruvate dehydrogenase protein X component, mitochondrial, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: LSHB_CERSI
Sequence: MEMLQGLLLWLLLSVGGVWASRGPLRPLCRPINATLAAENEACPVCITFTTSICAGYCPSMVRVLPAALPPAPQPVCTYHELRFASIRLPGCPPGVDPMVSFPVALSCRCGPCRLSSSDCGGPRAQPLACDRPPLPGLLFL
What is the function of this protein?
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
What are the official names of this protein?
Lutropin subunit beta, Luteinizing hormone subunit beta, LH-B, LSH-B, LSH-beta, Lutropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SDIM1_HUMAN
Sequence: MWPAPCSVGRLLIFFMCSSSGYVVQGCGPSPGARTTLGSPLSLWSIKTPSHIFCTRRAINLGFPSPPLVQLIFWSLNAGLDLYLCLISSCGFSQVFWPVEAFCSFSLSFFALALSHKFVICRLDQHIFSGFTKSLKNLPPCHRTDI
What is the function of this protein?
Promotes neuronal cells survival to stress conditions.
What are the official names of this protein?
Stress-responsive DNAJB4-interacting membrane protein 1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GATZ_SALPK
Sequence: MKEIIARHKAGEHLGICSVCSAHPLVIESALLFDLNTDNKVLIEATSNQVNQFGGYTGMKPADFRDFVYGIAQEVGFPRERLILGGDHLGPNCWQNEPAAAAMEKSVELIKAYVAAGFSKIHLDASMSCADDPTPLDPMVVARRAAVLCKAAEETANEEQKCHLTYVIGTEVPVPGGEASTIGSVHVTREVDAARTLETHQIAFRESGLEEALSRVIAIVVQPGVEFDHTQIIHYQPQAAQALSAWIKETPMVYEAHSTDYQTRQAYRALVRDHYAILKVGPALTFALREAIFALAQMENELISPEQRSRVLEVIDEVMLNEPGYWKKYYRPTWSQAMVDIHFSLSDRIRYYWPHPRIRQSVEKLIANLNNVTLPLGLISQFMPVQFERLSEGVLTPTPHNLIIDKIQDVLRAYRFGCTPDVA
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of GatY.  When expressed alone, GatZ does not show any aldolase activity.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. GatZ subfamily.
Protein: RL21_CLOBK
Sequence: MYAVVVTGGKQYKVAEGDVLFVEKLTADVDSTVELDNVLLVGKDNGETVVGKPMVEGAKVTAKVLAQGKAKKVVVFKYKPKKDYRKKQGHRQPYTKIQIEKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RPOC1_TRICV
Sequence: MLQSEKEFDYINIKLASPLRILQWSYRRLPNGQFIGEVQKSETINYRTFKPEMDGLFCERIFGPSRSFECACGKYKLIRYEGLICERCGVELTESRVRRHRMGHINLIYPVAHVWYTNSRPNYMALLLEVEQCEKNLNTSWQILRFSLPGIYDQVLRPILLSDHWPDSSIDEYLKTICKDFSTIALESSNIWAKKSKAWYQKIFEIYQELLYAKIETIYQFIEFIDNIDLTKQPTSVNFIFDYLENEKILDLMNPISLTNEITASQDPAQIDLVDPSRDIFLFLNTFPKKQHKELFRKLIRKSNTVKSLDDRIKRIKLASLAYFIAEDEISYYGLHWDLQQYRRSRELGFTAYPLKPEPKPKLQNRRYNTPKYLLRMTPTYLIGAVLIKKELEDLDIIKEIQRTRKFIVICSKILHKEKPIYHFLRWFRKWELQRAYKLRDQAIKRIRILENLLATGSNPAWMILTILPVIPPALRPMIQLEGGRFATSDLNELYRRIITRNNRLLRLLEIDAPQLIIRNEKRMLQEAVDTLIDNGKRGKIALSANNRPLKSLSDIIKGKHGRFRQNLLGKRVDYSGRSVIVVGPSLRLNECGLPYEMALELFQPFLIREMINQGLASNMKIARNLIEQNEAIIDPVLEKVLSNHPIFLNRAPTLHRLGIQAFEPILVQGRAIKLHPLVCSAFNADFDGDQMAVHIPLSLESQSECYMLMLAPYNFLSPANGEPIILPSQDMVLGCYYLTVSNIKGLLGSNQYFASLEDVLLAYNQDKIELHTAIWIRYTDNYIEPLNFKKQIQLNDASYIEIYENMQIRRDKDGNKIVQYLQTTTGRVIFNYTVQTTLNLLS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RAB17_HUMAN
Sequence: MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.  Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface.  Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis.  Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity).  May also play a role in cell migration.
What are the official names of this protein?
Ras-related protein Rab-17.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.
Protein: HBA_UROTO
Sequence: VLSPADKNNVKACWEKIGGHGAAYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVQGHGKKVADALANAAAHVDDLPSALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPAEFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: USPF_ECOL5
Sequence: MNRTILVPIDISDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPYYASLGLAYSAELPAMDDLKAEAKSQLEEIIKKFKLPTDRVHVHVEEGSPKDRILELAKKIPAHMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR
What are the official names of this protein?
Universal stress protein F.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
Protein: CXR32_DANRE
Sequence: MDNSTTAAEVSAPTDYDYNSTSYDDDNPYAAPCSLTETWNFLGRFAPVAYILVFILALVGNILVLCVIRRYRQSRHSPCSFSLTDTFLLHLAVSDLLLAATLPFFAVEWISEWVFGKVMCKITGALFSLNVYCGVLFLACISFDRYLAIVHAINISWRRKTCHAQLACAFIWVICLGLSMVDMHFRDLVEIPGMNRMVCQIVYSEQYSKQWQIGMQLVSMVLGFILPLLVMLYCYLHIFKALCHATRRQKRRSLRLIISLVIVFVISWAPYNALRMTDSLQMLGVIVKSCALNNVLDVGILVTESLGLAHCALNPLLYGLVGVKFRRELAQMCKAALGPQGCLGLVGWANGRGSSTRRPTGSFSSVETENTSYFSVMA
What is the function of this protein?
Receptor for the C-X-C chemokines cxcl11. 1 and cxcl11. 6 (PubMed:25573892).  Promotes macrophage chemotaxis to sites of bacterial infection (PubMed:20424185, PubMed:25573892).
What are the official names of this protein?
C-X-C chemokine receptor type 3-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCME_MANSM
Sequence: MNPRRKSRLTIILFVLLGVTIASSLVLYALRQNIDLFYTPSEVISGKNDDPDTIPEVGQRIRVGGMVVEGTVKRDPNSLKVSFNVNDIGPEITVEYEGILPDLFREGQGIVAQGVLKEPKLLEATEVLAKHDENYVPPDLSEKMEQVHKPMGISNQDMQGESDRDRLDKAVNSVEEGKK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: HCAE_SHIF8
Sequence: MTTPSDLNIYQLIDTQNGRVTPRIYTDPDIYQLELERIFGRCWLFLAHESQIPKPGDFFNTYMGEDAVVVVRQKDGSIKAFLNQCRHRAMRVSYADCGNTRAFTCPYHGWSYGINGELIDVPLEPRAYPQGLCKSHWGLNEVPCVESYKGLIFGNWDTSAPGLHDYLGDIAWYLDGMLDRREGGTEIVGGVQKWVINCNWKFPAEQFASDQYHALFSHASAVQVLGAKDDGSDKRLGDGQTARPVWETAKDALQFGQDGHGSGFFFTEKPDANVWVDGAVSSYYRETYAEAEQRLGEVRALRLAGHNNIFPTLSWLNGTATLRVWHPRGPDQVEVWTFCITDKAASDEVKAAFENSATRAFGPAGFLEQDDSENWCEIQKLLKGHRARNSKLCLEMGLGQEKRRDDGIPGITNYIFSETAARGMYQRWADLLSSESWQEVLDKTAAYQQEVMK
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase.  Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.
Protein: GPR15_HUMAN
Sequence: MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELTLIDDKPYCAEKKATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRQEHYLPSAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFARRRKRSVSL
What is the function of this protein?
Probable chemokine receptor.  Alternative coreceptor with CD4 for HIV-1 infection.
What are the official names of this protein?
G-protein coupled receptor 15, Brother of Bonzo, BoB.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPM5_HUMAN
Sequence: MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQLVAADHRGGLDGWEQPGAGQPPSDT
What is the function of this protein?
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction.  Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well.  Activated directly by increases in intracellular Ca(2+), but is impermeable to it.  Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+).  Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists.  The channel is blocked by extracellular acidification.  External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation.  Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius.  Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials.  Activated by arachidonic acid in vitro.  May be involved in perception of bitter, sweet and umami tastes.  May also be involved in sensing semiochemicals.
What are the official names of this protein?
Transient receptor potential cation channel subfamily M member 5, Long transient receptor potential channel 5, LTrpC-5, LTrpC5, MLSN1- and TRP-related gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ADCK5_HUMAN
Sequence: MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET
What is the function of this protein?
The function of this protein is not yet clear.  It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
What are the official names of this protein?
Uncharacterized aarF domain-containing protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LLDD_PSEU2
Sequence: MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSLETRLFGESLAMPIILSPVGLSGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQSDQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPYAAPRRILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWIREFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSDLTVLADSGIRSGLDVVRMLALGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMTLTGVTSIEQIDASILVKAVA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GSHRP_PEA
Sequence: MNQAMATPLSLSCCSPTLTRSTLFFTKTFPFSRSFSTPLPLSTKTLISLSPPHRTFAVRAESQNGADPARQYDFDLFTIGAGSGGVRASRFASNFGASSAVCELPFSTISSDTTGGVGGTCVIRGCVPKKLLVYASKFSHEFEESNGFGWRYDSEPKHDWSSLIANKNAELQRLTGIYKNTLKNAGVKLIEGRGKIVDAHTVDVDGKLYSAKHILVSVGGRPFIPDIPGKEYAIDSDAALDLPSKPQKIAIVGGGYIALEFAGIFNGLKSEVHVFIRQKKVLRGFDEEIRDFVAENMALRGIEFHTEESPVAITKAADGSLSLKTNKGTEEGFSHIMFATGRSPNTKDLGLESVGVKVAKDGSIEVDEYSQTSVPSIWAIGDATNRVNLTPVALMEGVALAKTLFQNEPTKPDYRAIPSAVFSQPPIGGVGLTEEQAAEQYGDIDVFTANFRPMKATLSGLPDRVFMKLIVSAETNVVLGLHMCGEDAAEIAQGFAVGIKAGLTKADFDATVGIHPTAAEEFVTMRTPTRKVRKNQASQGKSDSKAKAVAGS
What is the function of this protein?
Maintains high levels of reduced glutathione in the chloroplast.
What are the official names of this protein?
Glutathione reductase, chloroplastic/mitochondrial, GR, GRase, GOR1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion. Note=The majority of the protein is found in chloroplast, with only 3% in mitochondria.
Protein: MENG_SYNP6
Sequence: MSVLAPDAVEGLFDQIAPIYDNLNDQLSFGLHRLWKRMAVKWSAAKPGDRVLDLCCGSGDLAFLLAKVVGSKGQVIGFDRSQALLSVAGDRARQLASALVIDWQRGDALDLPFPDDHFDAATLGYGLRNVPDIPTVLRQLQRVLKPGARAAILDMHRPYSPLLRQFQQVYLDRWVVPAAAAQNCAAEYEYIDASLEAFPQGQQQVALAIAAGFQRAKHYELAAGLMGVLVVEA
What is the function of this protein?
Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
What are the official names of this protein?
2-phytyl-1,4-naphtoquinone methyltransferase, Demethylphylloquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.