PharMolix/UniProtQA huggingface dataset:
Protein: TYSY_SPHAL
Sequence: MADSIHYELQYLDLMRRIWVDGDERVDRTGVGTRSLFGETMRFSLKDDAIPLLTTKRVYWKTALRELLWFLTGDTNIRPLVAQGVKIWTDWPLEKYRKATGEAISATDFEARIVADADFAAKWGDLGPVYGHQWVNWPRYEPAGGGLFRRADHGYNQIAALIDSLKNNPGSRRHIFTGWNVADLDRMALPPCHMTYQFHVRSDGGLSCLLFQRSCDLGLGFAFNIFEAALLTRMVAEQCGLYAHEVVWTGGDVHLYLNHAELVEQQLARVPEGKPRLRILRRPPSIFEYRFEDFVVEDYAPQAHISAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTA_DANRE
Sequence: MSSAVPRSGFVVFCVLLVVTLALYPVLRTLGVQIYSAFTGKYVSGYHSLLLVNCPTEQTARDIGRIIMEKRLAACVNIFPRTATMYYWKGEIRDATEILLLVRTKTSLVQRLMTYITAIHPYDIPEIITFPINDGSQHYLKWIAEAVTDS
What are the official names of this protein?
Protein CutA homolog.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
Protein: QUEF_BACCZ
Sequence: MAGRLDEDLKDVTLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSLKLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEQMADYRMMNHDLYPETIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHYB_SOYBN
Sequence: MLQQAERRIPPFRRRKSTPHEQRLSHHSSNNNNNIDSMSKAIAQYTEDGVHAVFEQSGESGRSFNYSESIRIASESVPEQQITAYLVKIQRGGFIQPFGSMIAVDEPSFRILGYSDNARDMLGITPQSVPSLDDKNDAAFALGPQSVPSLDDKNDAAFALGTDVRALFTHSSALLLEKAFSAREISLMNPIWIHSRTSGKPFYGILHRIDVGIVIDLEPARTEDPALSIAGAVQSQEALVRAISQLQSLPSADVKLLCDTVVESVRELTGYDRVMVYKFHEDEHGEVVSESKRPDLEPYIGLHYPATDIPQASRFLFKQNRVRMIVDCHASAVRVVQDEALVQPLCLVGSTLGAPHGCHAQYMANMGSIASLVMAVIINGNDEEGVGGRSSMRLWGLVVCHHTSARCIPFPLRYACEFLMQAFGLQLNMELQLAAQSLEKRVLRTQTLLCDMLLRDSPTGIVTQSPSIMDLVKCDGAALYFQGNYYPLGVTPTEAQIRDIIEWLLAFHGDSTGLSTDSLGDAGYPGLPRLGMQFVGWQVAYITEKDFLFWFRSHTAKEIKWGGAKLILRTRMMGQRMHPLSSFKAFLEVVKSRSLPWENAEMDAIHSLQLILRDSFKDAEHRNSKAVVDPHVSEQELQGVDELSSVAREMVRLIETATAPIFAVDVDGHVNGWNAKVSELTGLPVEEAMGKSLVHDLVFKESEETVNKLLSREEDKNVETKMRTFGKEHQNKAAFLVVNACSSKHFTNNVVGVCFVGQNVTGQKIVMHKFINIQGDYKAIVHSPNPLIPPIFASDDNTCCLEWNTAMEKLDPSNENVTVGGVDVIGKMLVGEVFGSCCQLKGSDSITKFMIVLHNALGGQDTDKFPFSFLDRHGKYVQTFLTANKRVNMEGQIIGAFCFLQIMSPELQQALKAQRQQEKEFLGRMKELAYICQGVKKPLSGIRFTNSLLEATSLTNEQKQFLETSVACEKQMLKIIRDVDLESIEDGSLELEKGEFLLGNVINAVVSQVILLLRERNLQLIRDIPEEIKTLAVYGDQLRIQQVLSDFLLNIVRYAPSPDGWVEIHVRPRIKQISDGLTLLHAEFRMVCPGEGLPPELIQDMFNNSRWGTQEGLGLSMSRKILKLMNGEVQYIREAERCYFYVLLELPVTRRSSKKC
What is the function of this protein?
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region.  Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses.  Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc.  It also controls the expression of its own gene(s) in a negative feedback fashion.
What are the official names of this protein?
Phytochrome B.
What is the protein family that this protein belongs to?
Belongs to the phytochrome family.
Protein: SMB_ARATH
Sequence: MEIGSSSTVAGGGQLSVPPGFRFHPTEEELLYYYLKKKVSYEPIDLDVIREVDLNKLEPWELKEKCRIGSGPQNEWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKSIHLNSSKKIGLRKTLVFYTGRAPHGQKTEWIMHEYRLDDSENEIQEDGWVVCRVFKKKNHFRGFHQEQEQDHHHHHQYISTNNDHDHHHHIDSNSNNHSPLILHPLDHHHHHHHIGRQIHMPLHEFANTLSHGSMHLPQLFSPDSAAAAAAAAASAQPFVSPINTTDIECSQNLLRLTSNNNYGGDWSFLDKLLTTGNMNQQQQQQVQNHQAKCFGDLSNNDNNDQADHLGNNNGGSSSSPVNQRFPFHYLGNDANLLKFPK
What is the function of this protein?
Transcription regulator.  Together with BRN1 and BRN2, regulates cellular maturation of root cap.  Represses stem cell-like divisions in the root cap daughter cells, and thus promotes daughter cell fate.  Inhibits expression of its positive regulator FEZ in a feedback loop for controlled switches in cell division plane.  Promotes the expression of genes involved in secondary cell walls (SCW) biosynthesis.
What are the official names of this protein?
Protein SOMBRERO, NAC domain-containing protein 33, ANAC033.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPA_RALSO
Sequence: MTDSASGASAVANIATPSNEPYDATRKQKSLDKTARIPIKIVPAEKLKKPEWIRVKAATGNSRFYEIKDILRANNLVTVCEEASCPNIGECFGKGTATFMIMGDKCTRRCPFCDVGHGRPDPLDANEPENLAKTIAQLRLNYVVITSVDRDDLRDGGAQHYVDCISRTRELSPATRIEVLVPDFRGRLEKALDILQACPPDVMNHNMETVPRLYKQARPGADYAHSLKLLKDFKARNPNLPTKSGLMVGLGETDEEILEVMRDMREHDIDMLTIGQYLAPSGHHLPVLRYVHPDTFKMFEEKAYEMGFTHAAVGAMVRSSYHADQQAHEAGFA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP_STRGG
Sequence: MATKDTGGGQQKATRSTEEVEEQAQDAQASEDLAERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: MTTB_DESHD
Sequence: MARLRSMVQAGVARVEGFGLAGFSDEELYAIHTSTLEVLEYTGLKIESQEALEIFSEGGARVDFKTKVVKIPQYLVEDAIQSAPSTLVLAGRNPKNDIVLGGKRVGFINFGEGVSIIDPYTKEYRKTTRRDVANITRFCDAMDQMDAVLRPVAPQDIHPSVAVVHNAEVIFNNTSKHVFIGVEGGRNFKKVLKMAAAVAGGEDKLRERPLFSCNICPTSPLQIVNHASEVIIEGARAGIPVNMLSMGMSGATSAITLAGTLVTHNCEVLGAIVLSQLTSKGAPVLYGSSTTIMDMKNMTAPVGSPELGMINAGVAKLAQYYNLPSWVAGGOVDSKIPDAQASHEFTLTGFLTALAGANLIYGAGMLELGITFDYAQMLMDNEMARMIKKAVGGISVTDETLAVDVIKSVGTAGNFISEDHTYAHMRTQSQSKLVDRSMRENWLAAGAKDFTQRAYEEAISILENYTPEPLPEKIAATLRSIVEETEDEYGVARSLI
What is the function of this protein?
Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
What are the official names of this protein?
Trimethylamine methyltransferase MttB, TMA methyltransferase, Trimethylamine--corrinoid protein methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the trimethylamine methyltransferase family.
Protein: NFUA_HAMD5
Sequence: MITITEAAQNHFVKLLSSQPEGTQIRVFVANPGKPTAECGVSYCPADSVESADTHLKFNLFSVFVDPISAPYLNEAAIDFVTDELGSQLTLKAPNAKVRKVADDAPLIERVDYVLQSQINPQLANHGGRVTLMEITDDAFAVLQFGGGCNGCSMVDVTLKEGIEKELLQQFPELKGVKDLTEHQRGEHSFY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: DAPF_PSEMY
Sequence: MLLRFTKMHGLGNDFMVLDLISQHAHVQPKHAKQWGDRHTGVGFDQLLIVEPPSHPDVDFRYRIFNSDGSEVEQCGNGARCFARFVLDKRLTTKKTIRVETKSGVIELRVQNDGQVCVNMGAPRLEPAQVPFQAEQAALTYRVDVEGQSVELAALSMGNPHAVLRVDNVDSAPVHTLGPKLEHHPRFPQRVNVGFLQVLDRKHARLRVWERGAGETQACGTGACAAAVAAIRQGWMDSPVQLELPGGKLSIEWAGEGQPVMMTGPAARVYEGQVRL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSK11_ARATH
Sequence: MGCCQSSFLKPSSLHDKKITSDDLSGRRGKGAKRGNRHRHANINEGRGWHFSDVPDFSEFSASVLRDATNNFNKNAVVSVCSDQEPNLVYQGCIRSDKDKRLIAVKKFSKTTWPDPKQFATEARAIGSLRHVRLVNLIGYCCEGDERLLVSEYMPNESLTKHLFHWEKQTMEWAMRLRVALYVAEALEYCRQSGLKLYHDLNTCRVLFDENGSPRLSCFGWMKNSKDGKNFSTNLAYTPPEYLRSGTLIPESVVFSFGTFLLDLLSGKHIPPSHAVGTIQKQNLNVLMDSHLEGNYPEEDAAMVFDLASKCLHNNPNERPEIGDIISVITTLQQKLDVPSYTMLGISKLEKLEMEHPKSLIYDACHQMDLAALHQILEAMEYKEDEVTCELSFQQWAQQIKDVCNTRQQGDSAFRNKHFESAIDKYTQFIEIGIMISPTVYARRSMCYLFCDQPDAALRDAMQAQCVYSDWPTAFYLQAVALSKLNMVEDSATMLKEALILEDKRGS
What is the function of this protein?
Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.
What are the official names of this protein?
Serine/threonine-protein kinase BSK11, Brassinosteroid-signaling kinase 11.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MYORG_MOUSE
Sequence: MSQNLQETSQAYPRHRPGSHAGPKSLKVTPRATMYTFLPDNFSPAKPKPTKELRPLLCSAVLGLLLVLAAVVAWCYYSASLRKAERLRAELLDLNRGGFSIRNQKGEQVFRLAFRSGALDLDSCSRDGALLGCSRAADGRPLHFFIQTVRPKDTVMCYRVRWEEAVPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDAAFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSMRLQARYHDTSYKPPAGRTAAPELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPASEAFRDPIWSTWALHGRAVDQNKVLQFAQQIRQHRFNSSHLEIDDMYTPAYGDFNFDEGKFPNASDMFRRLRDAGFRVTLWVHPFVNYNSSSFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTHPEAREWFQGHLRRLRLRYNVTSFKFDAGEVSYLPRDFSTYRPLSDPSVWSRRYTEMAEPFFSLAEVRVGYQSQNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMIGGNAVPERTAGRQDGPGPERELYVRWLEVAAFMPAMQFSIPPWQYDAEVVAIAHKFAALRASLVAPLLLELAGEITDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAGKWRSYKGELFDKTPVLLTDYPVDLDEVAYFTWAS
What is the function of this protein?
Putative glycosidase.  Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (PubMed:19706595).
What are the official names of this protein?
Myogenesis-regulating glycosidase, Nuclear envelope transmembrane protein 37, Uncharacterized family 31 glucosidase KIAA1161.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
What are the subcellular locations of this protein?
Nucleus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Only a minor fraction is present in the peripheral endoplasmic reticulum (PubMed:19706595).
Protein: LEUD_STAS1
Sequence: MEIKPITTYTGKVVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLDDGSDNPDFNPNKPEYKDASILITGENFGCGSSREHAAWAIKDYGFDIIIAGSYSDIFYMNCTKNAMLPIVLDKEAREYLADAGEITIDLPNQTVSTKDKSFDFQIDETWKKKLVNGLDDIDITLQFEDAIKNYEAAKTY
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: DEOC_SHELP
Sequence: MSDLKKAAQKAIELMDLTTLNDDDTDQKVIELCHKAKTPAGNTAAICIYPRFIPIARKTLNEMGCEEIKIATVTNFPHGNDDIAIAVLETRAAVAYGADEVDVVFPYRALMEGNETVGYELVKACKEACGDDVLLKVIIESGVLQDPALIRKASELSIDAGADFIKTSTGKVEVNATLEAAEIMMTVIAEKNPKVGFKPAGGVRDAAAAEEFLGVAERLLGKGWATPRTFRFGASSLLNNLLHTLELAEAPKGPQGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_GRATL
Sequence: MNIKLTLLVLISIINLMIIQPIQTLAFPIYAQQGYENPREATGRIVCANCHLAQKPIKIEAPKTVLPNSIFEAIVKIPYDTNNKQLLGNGIKGSINTGAVMILPEGFKLAPKNLLSEELREKTKNVYIQPYSTTKDNILLVGPLAGEKNQEIIFPILSPDPSKDKNIHFLKYPIYIGANRGRGQVYPTGDKSNNNPIVSLNTGKVTKIISLEKGGYKIEIEKDNGEIYTENIPQGLNLMVSQGSQVVANQNLTDDPNVGGFGQTEIEIVLQSPSRIKGMIVFFFTVTIAQIFFVLKKKQWEKVQAAEINF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TF2B2_SACS2
Sequence: MKCPYCKTDNAITYDVEKGMYVCTNCASVIEDSAVDPGPDWRAYNAKDRNEKERVGSPSTPKVHDWGFHTIIGYGRAKDRLKTLKMQRMQNKIRVSPKDKKLVTLLSILNDESSKLELPEHVKETASLIIRKMVETGLTKRIDQYTLIVAALYYSCQVNNIPRHLQEFKVRYSISSSEFWSALKRVQYVANSIPGFRPKIKPAEYIPKILYKLNLPPIIGTKASELVDLMHKQGLTSGKGYLSLSAASVYLISALMDIKKTQKEVADSLDITEVTIRNRYKDIVDNFDIVVTL
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB 2, TFIIB 2.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: MTNC_KLEP3
Sequence: MIRAIVTDIEGTTSDIRFVHNVLFPYARERLAGFVTAQQYAEPVKTILDNLRRETDAPAASTADLITTLFAFMDEDRKSTALKALQGIIWRDGYLNGDFTGHLYPDVLPALEKWKAQGIDLYVYSSGSVAAQKLLFGYSDEGDITHLFTGYFDTLVGAKREVQSYRNIAEHLGHAPGTILFLSDIHQELDAAEAAGLRTIQLVRGDRDPASHHPQVQRFDDIHPEQIPA
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: RIOK2_HUMAN
Sequence: MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
What is the function of this protein?
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit.  Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm.  Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402).  Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
What are the official names of this protein?
Serine/threonine-protein kinase RIO2, RIO kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner.
Protein: IFNG_AILME
Sequence: MNYTSYILAFQLCVILCSSGYYCQAMFFKEIENLKEYFNASNPDVADGGPLFLDILKNWREESDKTIIQSQIVSFYLKLFENFKDNQIIQRSMDTIKEDMLFKFFNSSTSKRSDFLKLIQIPVNDMQVQRKAINELIKVMNDLSPRSNLTKRKRSQNLFRGRRASK
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: FTSZ_HELPJ
Sequence: MVHQSEMENYNIGQASIEEVSDPAYKGAKIVVVGVGGGGSNMIKHLVEYGVHQDVTPIATNTDGQHLKNNPAPVKILLGKESTGGLGAGGVPDIGKKAAEESADEIREAIKDAKLVIVSTGLGGGTGTGATPTIVKIAKEVGALTIAIVTKPFKYEGNQKRKRAEEGLKELEQSSDSILVIPNDKILLTMKKNASTTECYREVDDVLVRAVSGISTIITKPGNINVDFADLKSALGFKGFALMGIGEATGEDSAKLAVQNAIQSPLLDDASIEGAKSIIVFFEHHPDYPMMAYSQACDFIQDQAHQDVDVKFGQHTSENIPIDHVRVTIIATGSERNSNGAGLESIATPSQPVVKPTRKVGNGEYLRIPTEEELSIPTTIRIQQD
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: SYR_STRPS
Sequence: MNTKELIASELSSIIDSLDQEAILKLLETPKNSEMGDIAFPAFSLAKVERKAPQMIAAELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEHYADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGDWGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLENGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLLLESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQEQSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTIAEAVSRAKVQIEAKNPELENKDQVAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYVQYAYARIQSILRKADFKPETSGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIAKFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T132D_RAT
Sequence: MCPSEMGTLWYLWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSFFLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSLEQVVPQDLMLPSNPFGFTNTFSLNWRLKAYILQEKVYLSHPKVQVLFHIVGRDWDDHRDENLPCLRVFAFRETQEVRGSCRLGGALGLCVAQLEMLPGWFSPPSVVSGRRRPTEQPEGSPVELYYAVQPGDERGDCAKEDSRKSRGPPAGHNDVDESSPPLHRIGSVFLRETPSSPPLRELRLDSNVAVHYIPKTVRQGDVLTFPISVSRNCTEDRFTLRAKVKKGVSIVGVRASTSSLWDVKQSTEYTGKYAPAVIICQKKSAGSGKSVDDASYEVMKIDIEVEAPSDPPTTQLVTWQVEYPGEITSDLGVSKIYVSQKDLIGVIPLAMEAEILNTAILTGKTVAVPVKVISVEEDGTVQGLSDSVECRSSDEDVVKVSDRCDYVFVNGKEMKGKVNVVVTITYQHLSSPLEMTVWVPRLPLQIEVSDMELNQIKGWRVPVVSNKRPARDSEEEDDDEKRGRGCTLQYQHAMVRVLTQFVAEAPDPGGHLAHLLGSDWQVDITELITDFMQVEEPRIAKLQGGQILTGQELGMTTIQILSPLSDAILAEKTITVLDEKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDEKDFSLMATSLDEKVVSILQDPKFKWPIIAAENEGQGALVKVEMLISESCQKSKRKSVLAVGTASIKVKFGQNDANPNGSESGHLGAGLHVENINDRRSKKPFQEWGSPEGPYYSSSSMGLMEGWGSTTKRPTFPKKEGQENLLDDIILSQTMATDLTSFPDQVDLPGSNVGTEEHDPDQAAKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGLSHSHDWVGLSNRTELLGNHMNFASSQEEQITAIDRGLDFEESKLLLSSNSQNSINGQLFRSTGAMLTDDKEQKSEPPTSPTSKRKRVTFSTFSAISSDDGCPSGNTMVLSNEDDIKWVCQALDPGECPEPHSCMERLHEHV
What is the function of this protein?
May serve as a cell-surface marker for oligodendrocyte differentiation.
What are the official names of this protein?
Transmembrane protein 132D, Mature oligodendrocytes transmembrane protein, Mature OL transmembrane protein.
What is the protein family that this protein belongs to?
Belongs to the TMEM132 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DUSA_SHEON
Sequence: MLKNNINDSKNLDRTFSIAPMLDWTDRHYRYFARLMSANALLYTEMVTTGAILHGRGDYLTYNQEEHPLALQLGGSNPVELARCAKLAAERGYDEVNLNVGCPSDRVQNGRFGACLMAEPELVAECVDAMKQVVDIPVTVKTRIGIDEQDSYEFLTHFIDTVMAKGCGEFIIHARKAWLQGLSPKENREIPPLDYDRVYQLKRDYPALNISINGGITSLEQAQTHLQHLDGVMVGREAYQNPYMLAQVDQVLCGSTKAVMSREAVIEAMLPYIEAHLQVGGRLNHITRHMIGLFQGLPGARAWRRYLSENAHKNGAGIEVVKLAYQSVQTDLVAQ
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.  Specifically modifies U20 and U20a in tRNAs.
What are the official names of this protein?
tRNA-dihydrouridine(20/20a) synthase, U20-specific dihydrouridine synthase, U20-specific Dus, tRNA-dihydrouridine synthase A.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusA subfamily.
Protein: RS18_SALEP
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: Y106A_PYRHO
Sequence: MSKTITIADDVYYELVKMKGKRSFSEVLRELIGKKKEGNLDVLMIAFGTMDEEEAKELEEKIKEVGKWLNSWTPV
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Putative antitoxin PH1062.1.
What is the protein family that this protein belongs to?
Belongs to the UPF0330 family.