PharMolix/UniProtQA huggingface dataset:
Protein: LYRM2_HUMAN
Sequence: MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS
What is the function of this protein?
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
What are the official names of this protein?
LYR motif-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
Protein: RL20_DEIGD
Sequence: MPRVKTGIVRRRRHKKVLKRAKGFWGSRSKQYRNAFQTLLNAATYEYRDRRNKKRDFRRLWIQRINAGARLHGMNYSTFINGLKVAGVDLNRKVLADIAAREPEAFQVLVNTAKGARNG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RNC_LIMF3
Sequence: MITQLQDYLAKTYGIHFNNPALLAEAFTQASYVNEHPHENLKYYERIEFLGDAVLQLFVSEYIYRRYPELPQGKLTRLRAAMVCEDSFSKFAKECHFDQYIRLGKGEEMAGARNRASLLCDIFESFIGALYLDQGRQAVEQFIQTVIFPKLDLGWFDHAVDAKTSLQEFLQRNGDVAIEYDLLSEGGTENDPVFEVEVTVDGKKVATGQGSSKKHAEMEAAKHALEKLRMDK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_NEIMF
Sequence: MARKTPISLYRNIGISAHIDAGKTTTTERILFYTGLTHKLGEVHDGAATTDYMEQEQERGITITSAAVTSYWSGMAKQFPEHRFNIIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYQVPRLAFVNKMDRQGANFFRVVEQMKTRLRANPVPIVIPVGAEDNFSGVVDLLKMKSIIWNEADKGTTFTYGDIPAELVETAEEWRQNMIEAAAEASEELMDKYLGGDELTEEEIVGALRQRTLAGEIQPMLCGSAFKNKGVQRMLDAVVELLPAPTDIPPVQGVNPNTEEADSRQASDEEKFSALAFKMLNDKYVGQLTFIRVYSGVVKSGDTVLNSVKGTRERIGRLVQMTAADRTEIEEVRAGDIAAAIGLKDVTTGETLCAESAPIILERMEFPEPVIHIAVEPKTKADQEKMGIALNRLAKEDPSFRVRTDEESGQTIISGMGELHLEIIVDRMKREFGVEANIGAPQVAYRETIRKAVKAEYKHAKQSGGKGQYGHVVIEMEPMEPGGEGYEFIDEIKGGVIPREFIPSVDKGIRDTLPNGIVAGYPVVDVRIRLVFGSYHDVDSSQLAFELAASQAFKEGMRQASPALLEPIMAVEVETPEEYMGDVMGDLNRRRGVVLGMDDDGIGGKKVRAEVPLAEMFGYSTDLRSATQGRATYSMEFKKYSEAPAHIAAAVTEARKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EYA3_MOUSE
Sequence: MQEPREQTLSQVNNPDASDEKPETSSLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLIPTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAETTTLAATTYQTEKPSAMVPAPATQRLPSDSSASPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCANVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
What is the function of this protein?
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph).  'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.  Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity).  Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis.  The phosphatase activity has been shown in vitro.  Coactivates SIX1.  Seems to coactivate SIX2, SIX4 and SIX5.  The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity.  May be involved in development of the eye.  May play a role in mediating the induction and differentiation of cranial placodes.
What are the official names of this protein?
Eyes absent homolog 3.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. EYA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: RL23_ONYPE
Sequence: MNKYYDLVKAPIITELTNKLIERQNKYTFKVAKTANKVEIKKALESIFQVKVLSVNTRNVLPQFKRKGKFEGYTSGYKKAICKVAPGQKIEILANE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CREL2_BOVIN
Sequence: MRPPAPAVLGLLLLLLPTGEATKKPTPCKRCRELVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYEFSEVRLLEIVEGLCEASDFECNQLLEEQEELLEAWWLRLKKKHPDLFEWFCVQTLKACCSPGTYGPDCLACQGGSERPCSGNGHCVGDGTREGDGSCQCHLGYQGPLCSDCMDGYFRSPTSETHSICSACDEACKTCVGPTNRDCGQCEVGWVRQDDACVDVDECAAEPPPCEDTQYCENVNGSFVCEECDPTCMGCTGKGPTQCRECIAGYSKESGQCEDIDECSLAEKPCLRDNENCYNTPGSFVCVCPDGFEEAEDTCVQTRPAGAEATEASPTQPPSREDL
What is the function of this protein?
Protein disulfide isomerase (By similarity).  Might play a role in the unfolded protein response (By similarity).  May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity).
What are the official names of this protein?
Protein disulfide isomerase CRELD2, Cysteine-rich with EGF-like domain protein 2.
What is the protein family that this protein belongs to?
Belongs to the CRELD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: RAB28_HUMAN
Sequence: MSDSEEESQDRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIGGQTIGGKMLDKYIYGAQGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEHMRTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPMSRTVNPPRSSMCAVQ
What are the official names of this protein?
Ras-related protein Rab-28.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body. Note=Expressed in the basal body and ciliary rootlet of the photoreceptors.
Protein: VIPC_SALTI
Sequence: MITQEEKLAALGKTCLTLKQEKKLAQAVALIDSELPTEALTSLAMLKKAEFLHDVNETERAYALYETLIAQNNDEARYEYARRLYNTGLAKDAQLILKKVSNGVQKKYNNYLGKINKICDLLERLEGKAIPVGTNTCIIAMKHAILFYRNRQPRQLPVGSFGRLALCTGSLGSGGAERQISRLAIEIARKYRQKGKIGGLKVEEPVELIIRSLTPELRQDFFLKEVLEEQVEVLEIAKITGNLFDDATIESPELRLLLSHLPPVCKYGIKHLVPHLCERKLDYLSVWQDSACLMIALAALIAGVPRIQLGLRGLPPVVRKRLFKPEYEPLYQALAVVPGVDFMSNNHCVTRHYADWLKLEAKHFQVVYNGVLPPSTEPSSEVPHKIWQQFTQKTQDADTTIGGVFRFVGDKNPFAWIDFAARYLQHHPATRFVLVGDGDLRAEAQKRAEQLGILERILFVGASRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVISTPAGGSAECFIEGVSGFILDDAQTVNLDQACRYAEKLVNLWRSRTGICQQTQSFLQERFTVEHMVGTFVKTIASQPR
What are the official names of this protein?
Vi polysaccharide biosynthesis protein VipC/TviE.
Protein: ENO_STRP7
Sequence: MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: M3K8_MOUSE
Sequence: MEYMSTGSDEKEEIDLLIKHLNVSEVIDIMENLYASEEPGVYEPSLMTMYPDSNQNEERSESLLRSGQEVPWLSSVRYGTVEDLLAFANHVSNMTKHFYGRRPQECGILLNMVISPQNGRYQIDSDVLLVPWKLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFERKRLLSRKELQLPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
What is the function of this protein?
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses.  Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells.  Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production.  Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.  May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types.  In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis.  Plays a role in the cell cycle.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQOR_ENT38
Sequence: MAKVLVLYYSMYGHIETMAHAIAEGANKVDGVEVVIKRVPETMNAEAFLKAGGKTQNAPQATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWATGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYGAQELFDVSAVRGGTPYGATTIAGGDGSRQPSQEELAIARFQGEHVAGLAKKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ATPF_STRA3
Sequence: MSILINSTTIGDIIIVSGSVLLLFILIKTFAWKQITGIFEAREQKIANDIDTAEQARQQAEAFATKREEELSNAKTEANQIIDNAKETGLAKGDQIISEAKTEADRLKEKAHQDIAQNKAEALADVKGEVADLTVLLAEKIMVSNLDKEAQSNLIDSYIKKLGDA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: IOLG_RHOE4
Sequence: MSDNQDLRIAVLGVGIMGADHVDRITNKIGGARVTVVNDYSLARAEEIAALTPGSRVVVDPFDAIAAEDVDAVVLATPGPTHEKQVLACLEAGKPVLCEKPLTTDADSSLAIVKAEAALGKKLIQVGFMRRFDHEYTQLKYLIDSGDLGRPLVVHCAHRNPAVPNGFDSAMIVKDSLVHEVDVTRFLLDEEITSVQIIRPSANSLAPEGIQDPQIAIFETESGRHVDAEVFVTTGVAYEVRTEVVGELGSAMIGLDVGLIRKTKPGNWGGQITPGFRERFGQAYDTEFARWIKAVKTGAGTGNYIDGPGAWDGYAAAAVCAAGVKSLETGQRVVVDMVARDSVAGA
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: RL35_RHIL3
Sequence: MPKMKTKSSAKKRFKITATGKVKAAAAGKRHGMIKRSNKFIRDARGTMVLAEPDGRKVIKNYLPNGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RPOA_RICPR
Sequence: MLSLSKNWNTLIKPNRVTYENFPETNNKAKIIVEPLERGFGLTLGNAMRRVLLSSLQGAAITSIKIPAIEHEFSSIPGVQEDVSEVILNIKGIEVKMHVSEKRIIKLKAMGPCVVTAGMIDTGHDVEILNPDHVICNLAKNKQLEMELTCKVGKGYVLSTNSYEDNLPIGEIAIDALFNPVKSVTYKVENTRVGQVTDYDKLIMFVETNGDVLPEMAVGLAARILQEQLQLFIAFEEQEEDKQVKTDSLPFSPYLLKRVDELELSVRSANCLKNDNIIYIGDLVKRTESDMLRTPNFGRKSLNEIKEILAKFNLRFGMDVPDWPPENIQELSKRYEDSYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SECF_ECO57
Sequence: MAQEYTVEQLNHGRKVYDFMRWDYWAFGISGLLLIAAIVIMGVRGFNWGLDFTGGTVIEITLEKPAEIDVMRDALQKAGFEEPMLQNFGSSHDIMVRMPPAEGETGGQVLGSQVLKVINESTNQNAAVKRIEFVGPSVGADLAQTGAMALMAALLSILVYVGFRFEWRLAAGVVIALAHDVIITLGILSLFHIEIDLTIVASLMSVIGYSLNDSIVVSDRIRENFRKIRRGTPYEIFNVSLTQTLHRTLITSGTTLMVILMLYLFGGPVLEGFSLTMLIGVSIGTASSIYVASALALKLGMKREHMLQQKVEKEGADQPSILP
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYL_CAMLR
Sequence: MAYEAGKIEKKWQKIWQEKEYFEPKDDFSLPKKYILSMFPYPSGRIHMGHVRNYSIGDAMARYYRKKGFNVLHPIGFDSFGMPAENAAIKHGIHPKKWTYENIDYMQNELASLGFSFSKKRMLATSDPLYTKFEQEFFIKMYEKGLIYTKEAEVNWCENDKTVLANEQVEDGKCWRCGHEVIRKKMPGYYVKITAYADELLQDLKKLEGKWPSQVLTMQENWIGKSTGLSFDFDIEENNKISAKKINVFTTRAETIYGVSYIALAPDHEIVNELIDKKLLDQDVIAKIQNIQNQTPRQRQAAPKEGYFLNLYVIHPLSKEKIPLWVANFVLSDYGSGAVMSVPAHDERDYEFAKTYNLAIKKVIYKDENDAQCYTLKEGVLTSSGEFDQLECNDAREKISLKIESLGIGKKVTNFKIRDWGVSRQRYWGAPIPMIKCDSCGIVPQKIENLPITLPEDVVINGEGNPLDKHETWKECICPKCGKKAQKESDTLDTFFESSWYFARFASDDKTWQEKAVDEKSVNYWMNVDEYIGGIEHAILHLLYARFFQKALRDLGYLKDDEPFNRLLTQGMVTKDGAKMSKSKGNVVDPDYIIEKYGADSARLFILFAAPPAKELEWNDSALEGAFKFINRLYEKAMSLECGKLQEIDHQSLNKEEKYARLKVYEALKKSFEVYEESFAFNTLIAACMEALNALNAINHKEVSKEAFYIILNILEPIIPHVCFELSEYLFKCENFKVLKIKDEVFIKDSFNIAISVNGKKRAQIEINSEAKEDEILALAKENVAKWLEGKTIVKEIYIDKKLVNLVVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_STRAW
Sequence: MLDVNFFDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITYVDDERRTRDLPSLEAHVSVERQQIENRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMKQLRDRAQREIDRLDEVWTRFKNLKVQDLEGDELLYRELRDRFGTYFDGSMGAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTSNSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFVMKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDGALRNVKGEERSFASVAEAIMAFDAGELSLQSRVDIRFPVGTIPPRGWTPPAREEGEPEWQQGDTFRLRTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVNDLAERYPKVIVAATLDNLKAAGFYWATRSGVTVAISDIVVPEAKKEIVKGYEAQDEKVQKQYERGLITKDERTQELIAIWTKATNEVAEAMNANFPKTNPIFMMVDSGARGNMMQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTERGLKLKIAERGADGVLRKTDDVETSVYARMLAEDVVIDGKVIAPANVDLGDVLIDQLVHHGVEEVKTRSILTCESQVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRVRIEETEKTKKIVVTPDDGSDETAFPISKRARVLVTEGEHVEVGQKLTVGATNPHDVLRILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDAELLPGELVERSKFETENRRVVQEGGHPASGRPQLMGITKASLATESWLSAASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVEPTEEAKAAMYSAVGYDDIDYSPFGTGSGQAVPLEDYDYGPYNQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: CL18B_HUMAN
Sequence: MLHPETSPGRGHLLAVLLALLGTTWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQTAIEAFVCAYSPGGNWEVNGKTIIPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGLVWLSAAMGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS
What is the function of this protein?
Binds polysaccharides in a Ca(2+)-independent manner (By similarity).
What are the official names of this protein?
C-type lectin domain family 18 member B, Mannose receptor-like protein 1.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.
Protein: MOCS1_CAEEL
Sequence: MSCRAGKKLFQWSRVKSSTEEIVKQLTVPLREHAEPILTLTPEQKREAVRLKIQEIEHTKGQPPFFDMFMREHTYLRISLTEKCNFRCLYCMPAEGVPLKPKDKMLSNSEVLRLVKLFAAHGVDKVRLTGGEPTIRKDIVHIVEGISSTPGIKEVGITTNGLVLQRFLPQLRDAGLTKINISIDSLDREKFAKMTRRDGFDKVWKAIELARGYYPKVKLNVVVLKHQNENEVVDFVNLTKDRNLDVRFIEFMPFGGNEFKNDNFIGYREMLNLIVDKYGDGVIRLSDSPNDTTKAYKIDGFQGQFGFITSMSDHFCNTCNRLRITADGNLKVCLHGNSEVSLRDRIRCGDSDEQLSEVIQKAVNNKKARHAVFRNGRSEEPAKSSNDSYRGLTPVTSASSILVHLPSSSLYHSHLHSSRHFFISQIRCFSTTYSVSSITHLLTHVDNNGNAKQVDVSQKDTSTRTAVARGTIILTAEISRQISENTIKKGDVLTVAKIASILGAKQVANLIPLCHPIRLDFVDTVFNHDIENSKLHCISTARCSGNTGVEMEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTTYTIDNENQI
What is the function of this protein?
Probably forms a complex with isoform a that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Molybdenum cofactor biosynthesis protein moc-5.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.
Protein: SYFA_PONAB
Sequence: MADGPVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKRWELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVILKTYWVSKGSAFSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQEAA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_ACIFI
Sequence: MVVIRMARGGAKKRPFYHIVVADSRSRRDGRFIERLGFYNPIGAVAELRIDKERAAYWLSQGAQPSDTVAGFLKKEGVSKTGVASV
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HIS4_ALCBS
Sequence: MLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLHLVDLNGAFAGEPVNGDIVKAIAKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAVNEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVDVIDLAKQFENDGVSAIVYTDISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYENTLDFADGQALSDELSGA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P53_CRIGR
Sequence: MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLPSSDSIEELFLSENVTGWLEDSGGALQGVAAAAASTAEDPVTETPAPVASAPATPWPLSSSVPSYKTYQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPPGTRVRAMAIYKKLQYMTEVVRRCPHHERSSEGDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEEKNFQKKGEPCPELPPKSAKRALPTNTSSSPPPKKKTLDGEYFTLKIRGHERFKMFQELNEALELKDAQASKGSEDNGAHSSYLKSKKGQSASRLKKLMIKREGPDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: RK33_ANTAG
Sequence: MAKSKDIRIAITLECTSCSENDEKRFSGVSRYVSEKNRRNTPTRLELKKFCPYCYKHKIHREIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.