PharMolix/UniProtQA huggingface dataset:
Protein: RDRP_BNYVS
Sequence: MADSFGFTPMEVLLFGGESVQLLTSDMPIDVQWGFVHSTRCYALWKDDLIHLNPLLKYSQRIAKRWERLVSGFVGPVPLDKLLSLLAKLMRYCVNMGVSVQEIYLSDAIVSSSYMLHVSRSAGCVSFSWLYAKLSMFASCGKFWVGSSHHTAANMIEGSRAVNGPDVAISEMVEAFHLEVKSSLVVTVSLTPREKKILERELGFVPLYKQKSRAPRNHPVLAALREVMRQEYSASCNILNTKLKTLVVGAASREVNCYSSNPSVHYYFANKDSKDLVRTTLELLHSALATKYRNMESGERELMNNLKGCGYIVKRSVENAVYEVVSDKDVAEVLRYAQTVASTKKEAKKKPNTGKRKMVMSEATRRTIELHELSRIVAEEKKIPNHFHFDESDFASVGNFTQLVCEDVGYNFSVDAWLHLFEATGAQTAVGYMALPNELLFEHYPISDYYDYWEGVEKHGSLGGITISPLRNGQVVGMPTGVFQPVHFDKTSAGLGIPGSKMGAAERVICHMSDGLGNGYNHVKSDWQTLLKHPILSSSKYNFAVEVDLTGRYGCLATFRLTRVTGVKYVARTIKLRPEDRYVRVLDLLHIVRSIRLKGHAGLKEPYQYFPVYKREVDTPVSYCFSIAEKSLTVQNIANFIRHHIGGVSLVNKELVSAWRLNPQLVPSFAYAVYFYVVNLRGELDGMLQKLMKKGITWADRLKANVSAFLRDMVDPISFLWTWLFERRLVDQIFQDGTDVFYQMDRACVDEKALRLNDHIKITRDFLPADTLLPEGWSLDDWEKAPDSLKTLSAAASLPVECGAVNCVGKSFKSVRTLLPPSVVTSPVEQFFKSGGKFRDDAEFAELLSAHYRWQMDNSFCACQVCAALTGKTGSQVVECRWKAESMYTFSMSQTEVDDFRNEIKAQSIEKGNRFGEMLIGVHQKIPTQAFEVSVRLEYVKGGPGTGKSFLIRSLADPIRDLVVAPFIKLRSDYQNQRVGDELLSWDFHTPHKALDVTGKQIIFVDEFTAYDWRLLAVLAYRNHAHTIYLVGDEQQTGIQEGRGEGISILNKVDLSKVSTHVPIMNFRNPVRDVKVLNYLFGSRMVPMSSVEKGFSFGDVKEFSSLSNIPDTKIIHYSDETGEHMMPDYVRGVSKTTVRANQGSTYDNVVLPVLPSDLNLINSAELNLVALSRHRNKLTILLDNDGMNIGAVLKGMLEGVPEELERRDYIVGMYLGLHLPIKKEFFFPESEFAKSFRLMVAKYEAFVPYDSNLPTLVLQGDVVVLDIARVENDINDAFNCPDFYNLVSRPNNCLVVAISECLGVTLEKLDNLMQANAVTLDKYHAWLSKKSPSTWQDCRMFADALKVSMYVKVLSDKPYDLTYEVDGAGSSVTLHLVGKESDGHFIAAPLSPSLSTNERESGHDSKKPADDSDTFDAANLFADKGVSSADIEAFCAYLEKTLMATIMEYDLRLQSWANVVDDTDDFYQINISEFRQSTCFGKLLSALEVLKVDVSRKRFISDWLCKNLENKQFRWRWSSSVASTSSAGSNVDDDFVNMAGGKTDANVDPADVLRQSFMDYASEFVPILIAESPILMPLVEPEPILSKCMVPEFDAFLLIKEFDLDNGADEYQCAYLNESVANRVGDKFVSGVLDTDIISPLNLRGHPIAENVKYHSMCVAPAQIYFKRNQWQELQVQQARYLFRKVRNSPSSTQDSVARMVAQLFVSDCLVPNVADTFSASNLWRIMDKAMHDMVTKNYQGQMEEEFTRNAKLYRFQLKDIEKPLKDPETDLAKAGQGILAWSKEAHVKFMVAFRVLNDLLLKSLNSNVVYDNTMSETEFVGKINAAMNIVPDSAINGVIDAAACDSGQGVFTQLIERHIYAALGISDFFLDWYFSFREKYVMQSRYVRAHMSYVKTSGEPGTLLGNTILMGAMLNAMLRGTGPFCMAMKGDDGFKRQANLKINDQMLKLIKKETVLDFKLDLNVPITFCGYALSNGHLFPSVSRKLTKIAAHRFREYKHFCEYQESLRDWIKNLPKDPAVYADFLECNASLSCRNVDDVQRWLDAIISVSRIGREQFMMMFPIREVFMSLPPVEDSLGELSSTKVAVSIGDNVSNVVRKVARVDMKKF
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities.  Contains a cysteine protease activity responsible for autocatalytic processing of the 237 kDa protein (Potential).
What are the official names of this protein?
Replicase, 237 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: VP16B_DROME
Sequence: MDLQLDSESYWNRSSRAAFSFDDEDEVDLAPDLVSNGILADDTISEASFNNSVALNLSIKSILSEEALKLVLQEQALDDRVLPKGVSPEEELKLLRRQLQSTLYSPNLEATAQKLLQGKTAPLEMFKSLHEKQQLLDTLMAQGGGHAVITVLLFLKRTLNTTQFHGILRERPKALEQYLSYLKESGDLAGHIELLQLFGRHQEAALKQFQAALASGDTSTRKKHLQLLVDAYATAGVGVIPLYEQVFHAALKMQQLMEKDSALGKLLRDQPTPVEVLYACCQVNSNWKEQDMLKPVSPQRFAADQQISPAQYEWTALNERAQAQAYADLECIFERVPSWHPLKTKQFHISFDLTLAVLRLYELQAPSTVLQLFLSKMGNSVEKLALAQRVKCIKAVIDAMAGLKQQQELQQLKDTLPERSEEQFYCENALKSLQSKRWTTDNIKLKL
What is the function of this protein?
Essential for phagosome maturation and the innate immune response to bacteria.  During phagosome maturation it is required for the fusion of late endosomes/lysosomes and phagosomes.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 16B, Protein full-of-bacteria.
What is the protein family that this protein belongs to?
Belongs to the VPS16 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome.
Protein: YJCH_SHIFL
Sequence: MNGTIYQRIEDNAHFRELVEKRQRFATILSIIMLAVYIGFILLIAFAPGWLGTPLNPNTSVTRGIPIGVGVIVISFVLTGIYIWRANGEFDRLNNEVLHEVQAS
What are the official names of this protein?
Inner membrane protein YjcH.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLSY_STREM
Sequence: MKLILLILTAYLLGSIPTGLWIGQYFYNINLREHGSGNTGTTNTFRILGLKAGAATLLIDIFKGTLATLLPVLVGASNVSPIAIGFFAVLGHTFPIFAGFKGGKAVATSAGVLLGFAPLYLLFLAAVFVLTLYLFSMISLASLTASVVAVISVLTFPAAHFLLPGYDWLLTITIVVLAAIIILRHQDNMKRIKQQSENLIPWGLNLSKQQPASHH
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: T179B_DANRE
Sequence: MALPRPLLLELLLYGSCFICGIITAASVTISQGSFDGKCMLYGSVRLNSSTIDVLSFSSLSLCYFVSAISVCVAVFCFSLTLYWIYIAFVDGEIKREKLWMNVTLGLSGVFLFFLLVTGCILKIGRDRLCDSLLHTVSNITRCEEAQNKSWRSPINASQFYTRLHSAETAVWVNFFFWMIIVVLVLIQRHKGSEIRPGTEDPSAPPSETEPFFNRPGRP
What are the official names of this protein?
Transmembrane protein 179B.
What is the protein family that this protein belongs to?
Belongs to the TMEM179 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FTSH_CHLT2
Sequence: MAKDKKTNPESKKSFPTAFFFLLFGVIFGVVTVQNFFSAKKASVGFSHQLEHLVNLKLLIPEESRKTALNDNLVSFSGRFREVVPAEGQVRYQYLDLIERKHQIDFELEEASKSLTVLSKEVRNAITWFSAISGMPIPEAGYTISPRTDVGLSVLEPLVVYGPVDAQIVNLAALENRVRSLPKSTESLRVFGSDLYALIGKYLSPALGIGSESLKKEIKDLHQQVENSLTQVIEGDQAVALYKTVLETLHRISLALVSPEEGTRFHQLRSVRLYREDFNRCVKLLRESDETQVQLDKLRGELVQAVWYFNNQELSSRALEKQDPEVFSRWFEGAKQEWAAFSSNKSLSFRAPDQPRNLVLEKTFRSEEPTPHYSGYLFTFMPIILVLLFIYFIFSRQVKGMNGSAMSFGKSPARLLAKGQNKVTFADVAGIEEAKEELVEIVDFLKNPTKFTSLGGRIPKGILLIGAPGTGKTLIAKAVAGEADRPFFSIAGSDFVEMFVGVGASRIRDMFEQAKRNAPCIIFIDEIDAVGRHRGAGIGGGHDEREQTLNQLLVEMDGFGTNEGVILMAATNRPDVLDKALLRPGRFDRRVVVNLPDIKGRFEILAVHAKRIKLDPTVDLMAVARSTPGASGADLENLLNEAALLAARKDRTAVTAVEVAEARDKVLYGKERRSLEMDAQEKKTTAYHESGHAIVGLCVEHSDPVDKVTIIPRGLSLGATHFLPEKNKLSYWKKELYDQLAVLMGGRAAEQIFLGDVSSGAQQDIAQATKIVRSMICEWGMSDHLGTVAYDEHSEAAPTGYGSYHEKNYSEETAKVIDNELKTLLDAAYQRALDIINSHKEELELMTQMLIEFETLDSKDVKEIMDHSWDADKKRARMKEEGMLYKKISEDLPPPPPQENVQDGTSLKFNTST
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins (By similarity).
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: SLYX_HAEIE
Sequence: MQIQQMLENRIEELEMKIAFQEQLLDELNHALVQQQFDIDKMQVQLRYMANKLKDFQPSNIASQSEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: DYR_STAAC
Sequence: MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase, DHFR.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: DEOC_HISS2
Sequence: MQSYDIAQFIDHTALTAEKTEQDILDLCNEAIEHNFFSVCINSGYIPLARQKLQNTNVKICTVVGFPLGANLSTVKAFEAKEAIKAGATEIDMVINIGWIKSNQWESVKADIQAVLAACEGALLKVILETCLLTKEEIITACKICRELGVGFVKTSTGFNKGGATVENIALMRQVVGENIGVKASGGVRDTKTAIEMIKNGATRIGSSSGIAIINGLTDNNAIY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_STAA3
Sequence: MKLNTLQLENYRNYDEVTLKCHPDVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFNADYAKIEGELSYRHGTMPLTMFITKKGKQVKVNHLEQSRLTQYIGHLNVVLFAPEDLNIVKGSPQIRRRFIDMELGQISAVYLNDLAQYQRILKQKNNYLKQLQLGQKKDLTMLEVLNQQFAEYAMKVTDKRAHFIQELESLAKPIHAGITNDKEALSLNYLPSLKFDYAQNEAARLEEIMSILSDNMQREKERGISLFGPHRDDISFDVNGMDAQTYGSQGQQRTTALSIKLAEIELMNIEVGEYPILLLDDVLSELDDSRQTHLLSTIQHKVQTFVTTTSVDGIDHEIMNNPKLYRINQGEIIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y419_XYLFT
Sequence: MRGCNKETGEFLGPSRSQQRRTALEVLVLSEKLAALTPAQLAKLPIPERLLPHITETKRITSHIARKRQLAFLAKQMRREDDTTLEAIREKLNASGIQAQREVATLHRTEQWRKRLLEEGDSALTELLNQYPQADCGKLRQLLRNSKTEQARNKAPQAFRELYQVLHGLIITQNSDNQHQTPQ
What are the official names of this protein?
UPF0307 protein PD_0419.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: CHED_XANC5
Sequence: MSTAVQVDDVMRYRDSRFQTIAAKLLPTQYLVVDDDTALTTTLGSCVAACLRDPVLKIGGMNHFLLPKGQVGDGAPTRYGSYAMELLINDMLKRGAHRKRIEAKVFGGANVLKGFTSNPVGTRNAEFVRQYLQAEHIPIIAEDLCGIHPRKVWFFATTGRVVVQRLPHAHEAEVAATESAVRARLSKAPVTGGVELFE
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: PSAB_CYAM1
Sequence: MATKFPKFSQALASDPTTRRIWYGIATAHDFESHDGMTEENLYQKIFASHFGHLAIIFLWTSGNLFHVAWQGNFEQWVANPLKTKPLAHAIWDPHFGQAALKAFTRGDTVANISYSGVYHWWYTIGIRNNVELYTGALGLLVLSAVFLLAGWLHIQPKFKPSLSWFKNNESRLNHHLAGLFGVSSLAWTGHLVHVAIPASRGQHVGWDNFIMTPPHPAGLQPFFTGNWSVYAQSPDSMQHVFGTSQGAGTAILTFLGGFHPQTQSLWLTDMAHHHLAIAVIFIVAGHMYRTNFGIGHNLKTILEAHRPPSGRLGKGHIGIYQTLTNSLHFQLGLALASLSVVTSLVAQHMYAMPPYAYMAFDYVTQSALYTHHQYIAGLLIVGAFAHGAIFFIRDYDPEQNQDNVLARMLAHKEAVISHLSWVSLFLGFHTLGLYVHNDVVVAFGNPEKQILIEPIFAQWIQATSGKMLYGFQVLLSSSTSNASVAAQQLWLPGWLEAVNNESNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAMFWMLNTIGWVTFYWHWKHLSLWQGNVAQFNESSTYLMGWLRDYLWLNSSPLINGYNPYGMNSLAVWSWMFLFAHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWKDKPVALSIVQARLVGLVHFTVGYILTYAAFVIASTAGKFS
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: RPOA_CLONN
Sequence: MLEIEKPKIECVEASEDGTYGKFVIEPLERGYGITLGNSLRRILLSSLPGGAANSIKIDGVLHEFSTVTGVKEDVTELILNIKGLALKMNGEGPSTIYIDAQGPGEVTAADIISDGNVEIMNKDMHIATLDDDGKLYMEINVDNGRGYVTQNKNKKEDLPIGTIPVDSIYTPVKRVNFTVENTRVGQITDYDKLSIEVWTNGTIQPEEAISLSAKILIEHFKLFMTLTDHADNVEIMVEKEEDKKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELTERTIDDMMKVRNLGKKSLEEVQEKLAALGLGLKKSDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: NDK_DESHD
Sequence: MEKTFIMLKPDAVQRGLVGQIIARFEAKGCKLVGMKLMSVDQALAEQHYAEHKGKSFFEPTVQYIMSSPVVAMVWEGKNVVALARELMGATNPANANPGSIRGSFGMDISRNVIHGSDSVASAEREIALYFRPEELCDYRKAGEEWLSE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3PA_GRAGA
Sequence: MAFVAPVSSVFSTSSKSAVCSGRSSFAQFSGLKKVNNTARLQTAEQGSAFGGVSDANDAFFNAVNTMGAPARTSNAPSMKVRVAINGFGRIGRNFIRCWAGRTDSNMDVVCINDTSGVKTASHLLKYDSILGTFDSDVVAGEDSITVDGKTIKVVSNRNPLELPWKEMEIDIVVEATGVFVDAVGAGKHIQAGAKKVLITAPGKGEGVGTFVVGVNDHLYSHDKFDIVSNASCTTNCMAPFMKVLDDEFGVVRGMMTTTHSYTGDQRLLDAGHRDLRRARSAALNIVPTTTGAAKAVALVVPTLAGKLNGIALRVPTPNVSVCDVVMQVSKKTFKEEVNGALLKAANGSMKGIIKYSDEPLVSCDYRGTDESTIIDSSLTMVMGDDMLKVVAWYDNEWGYSQRVVDLGEVMASQWK
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, chloroplastic, NADP-dependent glyceraldehydephosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MINE_SHEDO
Sequence: MSLLDYFRSTKKPNTASLAKERLQIIVAHQRSGRGGGAPEYLPKMKQEIIEVIRKYVQISEDQVSVQLDQNDDNLSVLELNVTLPDTK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: TRI23_MOUSE
Sequence: MAALAVNKPGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGHIGQYGAAEEAIGTSGESIIRCDEDEAHVASVYCTVCATHLCSDCSQVTHSTKTLAKHRRVPLADKPHEKTMCCQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGTAENARSCVRAYFSDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSQVSTACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase.  Plays an essential role in autophagy activation during viral infection.  Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1.  In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM23, ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, RING-type E3 ubiquitin transferase TRIM23, Tripartite motif-containing protein 23.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.
Protein: TOXS_VIBPA
Sequence: MKIKVASAVLAVSILFSGWLYWGSDLKVEQVLTSNEWQSTMVTVITDNLPDDTVGPLRRVNVESNVKYLPNGDYIRVANIKLFAQGSTAESTINISEKGRWEVSDNYLLVSPSEFKDISSSQSKDFSEAQLRLITQIFKLDAEQSRRIDVVNEKTLLLTSLNHGSTVLFRN
What is the function of this protein?
Interacts with ToxR and stimulates its activity.
What are the official names of this protein?
Transmembrane regulatory protein ToxS.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein; Periplasmic side.
Protein: PSBN_ANGEV
Sequence: METATLVAIFISCLLVSFTGYALYTAFGQPSKELRDPFEEHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GLYA_CLONN
Sequence: MNFDNLALTDKEIFNIIQLENNRQNNTIELIASENFASKSVMEAMGSQLTNKYAEGYPSKRYYGGCEEVDKIESLAIERLKKIFGCEHANVQPHSGSQANMAVYLSVLEPGDTIMGMNLSHGGHLTHGSPVNFSGRLFNFVAYGVNKETELINYDEVRSLALQHKPKMIVAGASAYSRVIDFKRLKQICDEVGAYFMVDMAHIAGLIAAGYHPSPVPYADFVTTTTHKTLRGPRGGAILCKEKYAKQVDKAIFPGIQGGPLMHVIAAKAVCFGEALKDDYKNYIEQVVKNAKVLEEELKKYDFKLVSGGTDNHLLLIDLTNKDITGKDAEKLLDSIGITVNKNTIPFETKSPFVTSGIRIGTPAVTTRGFKEEEMKEIAYLINYVIENRDSDLSEAKNKVKEICSRHILYK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_ECOK1
Sequence: MKRIAFVFSTVPHGTAAGREGLDALLATSALTDDLAVFFIADGVFQLLPGQKPDAVLARDYIATFKLLGLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGHB_ECO57
Sequence: MAVIQDIIAALWQHDFAALADPHIVSVVYFVMFATLFLENGLLPASFLPGDSLLILAGALIAQGVMDFLPTIAILTAAASLGCWLSYIQGRWLGNTKTVKGWLAQLPAKYHQRATCMFDRHGLLALLAGRFLAFVRTLLPTMAGISGLPNRRFQFFNWLSGLLWVSVVTSFGYALSMIPFVKRHEDQVMTFLMILPIALLTAGLLGTLFVVIKKKYCNA
What are the official names of this protein?
Inner membrane protein YghB.
What is the protein family that this protein belongs to?
Belongs to the DedA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SLT_ENTCL
Sequence: ESIPFSETRGYVKNVLAYDAYYRHFMGEKDALMSDAEWQRRY
What is the function of this protein?
Murein-degrading enzyme.  Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan.  May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
What are the official names of this protein?
Soluble lytic murein transglycosylase, Peptidoglycan lytic exotransglycosylase, Slt70.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TASL_BOVIN
Sequence: MLSEGYLSGLAYRNDIQWSYPSSNEQVAEEKEEEMEATAAASLSYSSVDETQVQNLYVSCKSSGKVISSVYSRESQHSRNPRITVLQTNPNPVYESPNLAAVELYRDTSRETYLVPPSCKSICKNYNDLQIAGGQVMAINSATTDFPSEGSFQYGPLLKSSEIPLSMEDSMFTQPSDLPPTPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKLVELYKQYFMDTGFHDSSPTQILASELIMTNVDQISIQVSIEKNLEISKARDIVINRLLQYGSTEISTQSLHISQYSNVNP
What is the function of this protein?
Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9.  Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons.  Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
What are the official names of this protein?
TLR adapter interacting with SLC15A4 on the lysosome.
What are the subcellular locations of this protein?
Lysosome membrane. Endosome membrane. Nucleus. Cytoplasm. Note=Recruited to endolysosome following interaction with SLC15A4. May colocalize with TLR7 in the endosomal pathway.
Protein: FRXA_PYRFU
Sequence: MGDDGVGIKIGRELKRQGYKVEELGTDIFSLMRVYNGENKVIIVDAVLGEIPGKVVYFKGEDIFKKLRAEIRSAHFMGAVEGLKLLLEVDERLKNAELHFVGVTIKEPKLGLELSEEVKRAIPRAMELILSIIREGE
What are the official names of this protein?
Protein FrxA.
Protein: OPSG1_CARAU
Sequence: MNGTEGKNFYVPMSNRTGLVRSPFEYPQYYLAEPWQFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSSSHAFAGIAFTWVMALACAAPPLFGWSRYIPEGMQCSCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSASTQKAEREVTKMVILMVFGFLIAWTPYATVAAWIFFNKGADFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIFCGKNPLGDDESSTVSTSKTEVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Green-sensitive opsin-1, Green cone photoreceptor pigment 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CEAM5_HUMAN
Sequence: MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
What is the function of this protein?
(Microbial infection) Receptor for E. coli Dr adhesins.  Binding of E. coli Dr adhesins leads to dissociation of the homodimer.
What are the official names of this protein?
Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface.