Protein: VRTA_PENAE
Sequence: MLHPTEVEKFPPTLLYFGNEFPNDDVNELFRRLQQHSKDRRFRLLNAYLEESILVLQDEVAKLPHHIKSRVPYFDNIVTLSEHGYLRDLGLGAAMESAFLLILQLGLFIGNHEAVDRELNLPKNVTTVAGLSVGLFSAAAIALSASLAEVVRNGAECLRVSFRLGVYAGDFSSSLEAPQPEGMLASWAHVVTGMTEESVQSELTRVNEDLGNPETSKVFISAADKSSVSVSGPPSRIKAAFLQSSDLRYSKSLPLPVYDGLCHATHIYSQDDVNTVLEISESLIPATRPFQLSVISSRTGVPFTATTASDLLSEIATELVMGTIYLDNIIEGIVRHIGAFPGAQSCRIDSFRTSIIFKGILEAIATDHPDLTIEKNDLVDWVHQDFGTRRRNDPANSKLAIVGMACRMPGGANNVEEFWQLLEQGRDACTTVPPDRFDLETHYDPTGKTENAAQTPYGNFIDRPGYFDAAFFAMSPKEAEQTDPMQRLAIVTAYEAMEMAGLVIGRTQSTRRDRIGSYYGQASDDWRELNASQNIGTYAVPGGVRGFTVGRINYFFKLSGPCLCIDTACSSSMAAVHAACTALWAGDVDVALAGGVNIITDPDNYAGLGNAHFLSPTGQCKVWDKGADGYCRAEGIGSVVIKRLEDAEADNDNILAVVLSAATNHCADAISITHPHAGHQKDNCRRVLRKAGVSPMQVSYVEMHGTGTQAGDAIESESVLDVFAPLKPLRRPDQRLHLGAVKSNIGHGEAAAGISSLIKMLLMFQKNAIPPHIGIRTEMNPQLPKDLGRRNAGLVFETTPWLRPEGKKRISVVNSFGAHGGNTTLLLEDAPERHRQRISPESTDGRSVYAISVSAKSKKSLQGNLSSLLGYLEQHPDTDLADLSYTTCARRTHHNLRVATVVSSVSALQKFLRSAIDSNIATTVQSVPSNIPSVVFTFTGQGASDRGVRQELFDDFPAFRTQVLQLDQLVQRLGFPSVVPALRGSTDEEVLSPVVSQLSIVVLEIALSRFWRLLGIRPSAVIGHSLGEYAALEVAGVLSAADVLYLVGRRAQITEQRCTPYGHSMLSVLATPDEIDRVVRRVPETSNVEYEVSCQNTHEDTVLGGAKADIEAIRKVLETTSYKCVPLAIPFAYHTSQMDVVVDELEEIAKNIPFKAPSIPVLSTMLGTVVFDGKTINPTYLRRQTRGTVKFVAAVETARDLGLIDEKTVWVDLGPHPVCVGFIRKLSPESRIAASCRRNEENLSTITKSLVTLHLAGATPLWNEFFRPNEQVYRLLNLPKYSWNETNYWIPYLGTWALDKALLKYGITPVGAKAPATLPAAGLRTSTIHQTTLETIDSMTATLHVLSDMQAPEFRAAVYGHTMNNCGVATSSIWTDMALAVGEYLYRKLVPQAKEVHMNVCDLEVLHAQVISKVKGCSQPLALEAHLDLDMQYMSLKWYNTNAATGERAPEWFASAAVRFENPDAWTAEWNRTGHLVLGRIETLRRLAADGVANRISKRLAYTLFKNVVDYSDWYRGIDDVIMNDYEAVANVTLIPDRHGTWHTPPHWIDSVCHLAGLIMNGSDASNTQDFFYVTPGSDSFRLLKPLAPGAKYISYVRMFPLSAEAGNMYAGDVYILKDDVIVGVLCQIRFRRVPRLLMDRFFSPPTADNAGVHGTPGSQRSQAPPAATHAATKSPQKTLQVPSGHVPNKASIVDTNHVQASHPSAVPVRHDQSNGVSGVSDSDSSTSITSSNSTADTSTTPTESEDADSGLVGQCIKIISRETNLDMSELTPDATFAQLGVDSLMSLVLSEKFRNELGIDVKSSLFLECPTIGEVKEWIDQNC
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system (PubMed:20534346).  The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA (PubMed:20534346).  The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB (PubMed:20534346).  The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone (PubMed:20534346).  The cyclization of the last ring could be mediated by the lactamase-like protein vrtG (PubMed:20534346).  The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF (PubMed:20534346, PubMed:24161266).  VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin (PubMed:20534346).  Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin (PubMed:24161266).
What are the official names of this protein?
Non-reducing polyketide synthase vrtA, Viridicatumtoxin synthesis protein A.