PharMolix/UniProtQA huggingface dataset:
Protein: REV_HV2SB
Sequence: MTERADEEGVRRKLRLIRLLHQTNPYPQGLGTARQRRNRRRRWERRWKQILALADRIYTFPDPPADPPLDQTIQQLQGLTIQTLPDPPTTQRLAETQGSLPAVWVRVDPRSVPGPREGYKRDSYERGEELVGGSGTNRKGDTRSSTKDQAGSRNCPPVRDRDISKETL
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: RS7_MOOTA
Sequence: MPRRGRVPRRAVLADPLYGNTKVTKLINQVMLDGKKSLAQRICYDAFEIIKNKTGKDPVEVFEQALKNVMPVLEVKARRVGGANYQVPVEVRPERRQTLGIRWLVNYARARSGKSMQEKLAAELIDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: DBP8_ASPOR
Sequence: MDYAICPRTKLNGFRTTLNVSPWLVGSLTTMAVRKPTAIQKACIPEILKGRDCIGGSRTGSGKTIAFAVPILQKWAQDPFGIFAVVLTPTRELALQIYEQIKAISAPQSMKPLLITGGTDMRSQALALSQRPHVVIATPGRLADHINTSGEDTVCGLKRVRMVVLDEADRLLAPGPGSMLPDVETCLSALPPSSERQTLLFTATLTPEVRALKSMPRAENKPPVFVTEISTENNGAIPPTLKQTYLKVPMTHREAFLHVLLSTERNSTKPAIIFCNHTKTADLLERMLRRLSHRVTSLHSLLPQSERNSNLARFRASAARILVATDVASRGLDIPSVSLVINFDVPRNPDDYVHRVGRTARAGRHGEAVTLVGQRDVQLVLAIEERVERRMEEWSEEGVSIEGRVVRGGVLKEVGEAKREASGEIEEGRDVLGRKRNKLKKVR
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RPOA_CHRSD
Sequence: MQRSVTEFLRPRDIKVEEINANHAKIVLEPFERGFGHTLGNALRRILLSSMPGCAVVEAEIEGVLHEYSAIEGVQEDVIEILLNLKDVAVKMHGNRDEVVLALSKQGPSVVTAGDIAVDHDVEIVNPDHVIAHLNDSGELKMQLKVVRGRGYEPADTRASEEDESRAIGRLQLDATFSPVRRVSYSVEAARVEQRTDLDKLIIDLETDGTLDPEEAIRRSATILQEQLAAFVDLEADKEQEVEEEEDQIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLNEIKDVLAARGLSLGMRLENWPPASLKDDKASA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RS21_ALTMD
Sequence: MPIVKVRENEPFDVALRRFKRSCEKAGVLSEVRRREFFEKPTWERKRKKAAAKKRHLKKLARENARRVKLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: THIC_MICAN
Sequence: MRQEWVAPRRGQANVSQMHYARQGIITEEMTYVAKRENLSPELIRSEIARGRLIIPANINHLNLEPMAIGIASKCKVNANIGASPNSSNINEELEKLHLAVKYGADTVMDLSTGGGNLDEIRTAIINASPVPIGTVPIYQAVESVHGNIEKLTPEDFLHIIEKHAGQGVDYMTIHAGILIEHLPLVKTRLTGIVSRGGGIIAKWMLHHHKQNPLYTHFDEIIEIFKRYDVSFSLGDSLRPGCTHDASDAAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAALAGWYGTAMLCYVTPKEHLGLPNAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSIARYNFDWNRQFQLSLDPDRAKEYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADAITELEKFLASQNQDNLTPV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: GLMU_OENOB
Sequence: MSEVDVVILAAGKGSRMKDDLSKPLHKVAGLPMLEWICRAVRKFNPKNIIAVQGADEDFSSYVDETVVQKEQLGSADALRCAFPKIDAEKLIVINADMPLMTENDLVDLVEKGEGFDAALLTADLKKPFGYGRVIPVGERNVVEQIVEERDATADQKKLHLVNAGVYLFRADYIKRAINNVTTDNSQSEYYLTDALPGAKIVQVADWHDILGVNTQQQLAAVSKIARKRINDQIMANGVTMIDPLTTYIDANVLVGTGTIIKPGTVIEHDSVIGAENEIGPYAHLREKTVTGIDVHIGNFVETKNAKIGDHTHIGHLTYVGDAEVGQAVNIGAGTIFVNYDGKNKHMTKVGDRAFIGSNSKLVAPVEIASEAITAAGSTITDNVDQHAMGIARQRQTNKSDFWQRMPHEDFATEYDAKHDQRDDQP
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGH1_MOUSE
Sequence: MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCDCTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLAQQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRSTEL
What is the function of this protein?
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response.  The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes.  This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.  The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons.  Involved in the constitutive production of prostanoids in particular in the stomach and platelets.  In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.  In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.  Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products.
What are the official names of this protein?
Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the prostaglandin G/H synthase family.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RR8_CHAVU
Sequence: MSKDTISNMITSIRNGNLSKAKIVQIPATQTARSIAKILLDEGFIENFREVVISDKNYSLLTLTLKYQGRTREPYITTLRRISKPGLRSYSSYQDIPKVMGGMGIVILSTSQGIITDRQARQRRIGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TIG_MYCVP
Sequence: MKSTVEKLSPTRVRINVEVPFTELEPDIDRAFKQLAKQIRLPGFRPGKAPRKLLEARVGRGAVLEQVVNDALPARYSEAVTAESLQPIGQPEIEVTKLEDNEELVFTAEVDVRPDIDLPDLGALKITVDPISVTDEDVDAEIEALQKRFGTLTGVDRAAEDGDFVSIDLSATVDGKDVPEANTEGLSHEVGSGQLIEGLDEAIIGLKADESKVFTTTLVAGEHAGQEAEVTVTVKSIKVRELPEVDDDFAQLASEFDTVEELRADLKEKISRFKRVQQAEAIRDKAIEVLLEQTEIPVPEAVVQAQVDDTLHNAIHGLDHDEDKFAESLKEQGSSREEFDADNRANAEKAIKTQLLMDSIADKLEIQVGQNDLTERLVLMSRQYGLEPQQLLQMLQQNNQLPAMFADVRRGLTVAAVVHGATVTDTDGAEIDTAEFFGPSGEQAEAEQDEAAPAEDATEETDADSDEAADDSK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: I17RA_MOUSE
Sequence: MAIRRCWPRVVPGPALGWLLLLLNVLAPGRASPRLLDFPAPVCAQEGLSCRVKNSTCLDDSWIHPKNLTPSSPKNIYINLSVSSTQHGELVPVLHVEWTLQTDASILYLEGAELSVLQLNTNERLCVKFQFLSMLQHHRKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKIIFVPDCEDSKMKMTTSCVSSGSLWDPNITVETLDTQHLRVDFTLWNESTPYQVLLESFSDSENHSCFDVVKQIFAPRQEEFHQRANVTFTLSKFHWCCHHHVQVQPFFSSCLNDCLRHAVTVPCPVISNTTVPKPVADYIPLWVYGLITLIAILLVGSVIVLIICMTWRLSGADQEKHGDDSKINGILPVADLTPPPLRPRKVWIVYSADHPLYVEVVLKFAQFLITACGTEVALDLLEEQVISEVGVMTWVSRQKQEMVESNSKIIILCSRGTQAKWKAILGWAEPAVQLRCDHWKPAGDLFTAAMNMILPDFKRPACFGTYVVCYFSGICSERDVPDLFNITSRYPLMDRFEEVYFRIQDLEMFEPGRMHHVRELTGDNYLQSPSGRQLKEAVLRFQEWQTQCPDWFERENLCLADGQDLPSLDEEVFEDPLLPPGGGIVKQQPLVRELPSDGCLVVDVCVSEEESRMAKLDPQLWPQRELVAHTLQSMVLPAEQVPAAHVVEPLHLPDGSGAAAQLPMTEDSEACPLLGVQRNSILCLPVDSDDLPLCSTPMMSPDHLQGDAREQLESLMLSVLQQSLSGQPLESWPRPEVVLEGCTPSEEEQRQSVQSDQGYISRSSPQPPEWLTEEEELELGEPVESLSPEELRSLRKLQRQLFFWELEKNPGWNSLEPRRPTPEEQNPS
What is the function of this protein?
(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway.
What are the official names of this protein?
Interleukin-17 receptor A, IL-17 receptor A, IL-17RA.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: AGRIN_DIPOM
Sequence: VPLSPVCGSDGVTYDSECALKLMRCMIQKDLHVVMLSPCKDASPSSVPELHCSRSVYGCCRDNVTAAQGVGLAGCPSTCECNRYGSYSKTCSPSSGQCSCKPGVGGLKCDRCEPGFWNFRGIVTDEKSGCTPCNCYPLGAVRDDCEQMSGLCSCKAGISGMKCNQCPNGSKLGPSGCDQDPSVSRTCSDLHCQYGATCVQSIGRAYCECPPSICPKNKQFKVCGSDGVTYANECQLKTIACRQGSVINILHQGPCQGTTPSTGNIQTTDLTPSPKEHTNLSKIVSLETIPILKAIFPVTDNTTGPQVHKMYTVTASPGVIGHPTAGWPPSSLTSSEPPDLSGSGDFSGDTDLEASGNLEGSGVEPMGFNESSTGPPTPVPNERSTCDNTEFGCCSDGKTPSVDGEGSNCPPTKLFQGVLIVEEVEGQELFYTPEMDDPKSELFGETARSIENALNELFGNSNVKKDFKSVRVHGLGPSDPVRIIVEVHFDPRTSYNSHDVQRALLQQVKQSRRKSIVVKKPEQDNVKIVDFDWAPLLFTTTSTTAARTTVPITTASALPVTRRPPPATTRWPKVLPHAKVPSTTTKPATTRRPPFSRKVEVRPATVKVHRPCDSQPCLHGGTCEDDGVSYTCSCPAGRGGAVCERTIVYFIPEFGGRSYLAFKTMKAYYTVRISMEFRASNLDGLPLVQWTEKGKGLHFYRPSEGYVELRFNHGVWDGVITSKTLIKPGNWHHVVGNRNRRSGMLSVDGEPHLIGESPPGTDGLNLDTDLFLGGTPEDEMTLVTERTTATKGLQGCIRLLDVNNLIYDLQERSNDVLYGSGVGECGNNPCSPNPCKNRGKCHMKEAEMFHCESVGEFSGPTCADKHNPCDPNPCHQSANCMVLPEGGSKCECPMGREGELCERVSEAEQDQGKAFIPEFNGLSYLEMNGIHTFVSDLLQKLSMEVIFLAKDPNGMIFYNGQKTDGRGDFVSLNLRDGYLEFKYDLGKGAAVLRSKAPIPLNVWNVVTVERNGRKGLMKINKDELVSGESPKSRKAPHTALNLKEAFYVGGAPDFNKFARAAGIISGFTGAIQKLSLKSIPLLKKENIRNAMEISNFRWHACTKTRNPCQNGGVCSPRLREYDCMCQRGFSGPQCEKALEEKSASGSESVAFNGRTFIEYHNTVTRSEKAVQVNYFEMSIKTEATKGLILWSGKIAEKSDYIALAVVDGFVQMTYDLGSKPVTLRSTIPVNTNQWVRIKANRIHGYGTLQVGNEAPVTGSSPFAATQLDTDGALWLGGIEKLAPGNRLPKAYSTGFIGCIKDVVIDRQELQLVEDALNNPTILHCPAKK
What is the function of this protein?
Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle.  Ligand of the MUSK signaling complex that induces the phosphorylation of MUSK, the kinase of the complex.  The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane (By similarity).
What are the official names of this protein?
Agrin.
What are the subcellular locations of this protein?
Note=Synaptic basal lamina at the neuromuscular junction.
Protein: NADE_BURO0
Sequence: MTSADYASRQRAIIAELNVAPHFDAEAEIARRIDFLAQYLRSTGLRTYVLGISGGVDSSTAGRLAQLSVERLRADGYDARFIAMRLPNGVQNDEEDAQRALAFVRADEVLTVDVKPAADAMLRSLVASGHAFETPAQQDFVHGNIKARERMIAQYAVAGARRGIVIGTDHAAESLMGFFTKFGDGGADILPLAGLSKRRVRGVARALGGEELIVMKVPTADLEELRPLRPDEHAYGVTYDEIDDFLEGKPVADRVYETVLRFYDGSRHKRALPYTMFDWPAA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: PUR7_ECO55
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y1601_CHLCH
Sequence: MIVNEFEKLTAGKLLLASATMLESNFKRTVLLMCEHNEEGSLGFILNRPLEFKVREAIHGFNDVDDVLHQGGPVQVNSIHFLHSRGDLIHNSQEVLPGIYWGGNKDEVSYLLNTGVMHPSEIRFYLGYAGWSAGQLFSEFEEGAWYTAEATPDVIFSDAYERMWSRTVRAKGGAYQLIANSPELPGMN
What are the official names of this protein?
UPF0301 protein Cag_1601.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: TIG_BORHD
Sequence: MILNDDVKLIPGSKVEAVIKISKEFVKGKYNEILQDYSSRLKIKGFRIGKVPFSIIEGKYSDNIRALTIEKLIHKSLEEFFKSATYKPLGYAVPKILDEKLEIDFNKDFEFTVVYEAYPEFEIPDISNVEVEIPEVTVSDSDVEDELKLLQLENAMVVDDSGDVKVGSIVRVDFVELDDSLSEILTTKRQDFVFTVGESNNYYGFDNDIIGMKKDEEKIIEKNYSADYKFSELANSFKRLKIIIKDIKKRDIPELDDDFAKDIKDSFNTLEELKAHIRENMLRLVKEKRESLKLSKLLSDVSEKLNIEIPSAMFEAELKNVVNEFSTQNKIDLKKLNDSSMGLEGVSDVFKENVLKKLKSKLVFQKIVDNDLTEITDADLEDELVKQAEDTKMRLSEIKKFYQEKNLLGILKDEIKRQKVKDKILKNVKEIKLKEIAFRDFINYKTGE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: VKOR1_HUMAN
Sequence: MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
What is the function of this protein?
Involved in vitamin K metabolism.  Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.  Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
What are the official names of this protein?
Vitamin K epoxide reductase complex subunit 1, Vitamin K1 2,3-epoxide reductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the VKOR family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MQMTN_HELPJ
Sequence: MQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESAIFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEKAGMSFDEFLEKSAHTSAKFLKSMVDEL
What is the function of this protein?
Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species.  Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose.  Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine.  These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.
What are the official names of this protein?
Aminodeoxyfutalosine nucleosidase, AFL nucleosidase, Aminofutalosine nucleosidase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 6-amino-6-deoxyfutalosine N-ribosylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: PROB_PSEE4
Sequence: MRSKVTGAQRWVVKIGSALLTADGKGLDRGAMAVWVEQMVALREAGVELVLVSSGAVAAGMSQLGWTSRPSAMNELQAAASIGQMRLVQAWESSFGEHGKHTAQILLTHDDLSDRKRYLNARSTLRTLVDLGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPEAQLIYEARADDPALDAVAGGTGGALGRGGMQTKLRAARLAARSGAHTIIIGGRIERVLDRLKAGERLGTLLSPERGMLAARKQWLAGHLQTRGTLVLDDGAVKALRESNKSLLPVGVKTVQGSFRRGEMVVCVGQDGHEIARGLANYSALEAQKIIGQPSDAIESLLGYSAEPELVHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_STRSY
Sequence: MTVIDGKALGVKLQAALAEKTARLKEEKGLVPGLVVILVGENPASQVYVRNKERSALAAGFKSEVVRVPDTISESDLLDLIERYNQDDEWHGILVQLPLPAHISEEKVLLAIDPDKDVDGFHPTNMGKFWSGHPVMIPSTPAGIMEMFKEYQIELEGKSALVIGRSNIVGKPMAQLLLDADATVTIAHSRTKNLPDLARQADILVVAIGRGHFVTKEFVKLGAVVIDVGMNRDENGKLIGDVKYDEVSEVASYITPVPGGVGPMTITMLMEQTYEACVRSAK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: YOU2_CAEEL
Sequence: MSNSTMEATQMKVKLAVDEMIDDLDKTYLRDMQKSMFQCSARCCDNKKTTRDAVENCVESCNDGMKKAQGYLEKELGGLQDQLSRCAMTCYDKLVQQFGPDVNKYSESQKLSFNEKLDSCVSVCADDHIKLIPAIKKRFAKNT
What are the official names of this protein?
Uncharacterized protein ZK637.2.
What is the protein family that this protein belongs to?
Belongs to the FAM136 family.
Protein: NU1M_ORNAN
Sequence: MFLVNLLILIIPVLLAVAFLTLLERKILGYMQFRKGPNIVGAHGLLQPIADAVKLFTKEPLRPLTSSIYMFILAPILALSLALTIWIPLPMPLPLIDLNLGLLFVLSVSGLSVYSILWSGWASNSKYALTGALRAVAQTISYEVTLAIILLSIMLINGSFTLTTLNLTQEYMWLIVPTWPLMLMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFLAEYANIIIMNALTVILFFGTYHLIFLPEMSTTTFMIKTMLLTSLFLWIRASYPRFRYDQLMHLLWKNFLPITLVTCLWYIMLPTTLSGLPPQM
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IRS1_XENTR
Sequence: MEDIKKCGYLRKQKSMRKRYFVLRCPGTRGPARLEYYENEKKFRVAEGSGGPRGVLNLEEAFGVNKRSDAKKRHLLVIYTRDGGLGVSADGEEEQDEWYQAILEVQAQARALSSSPDAPAWPGPAFREVWQVSVRPRGLGQTRNLSGIYRLCLAERTLGLLRLRSENPSVTLQLMNVRRCGHSDNYFFVEVGRSAVTGPGELWMQVEDSVVAQNMHETILEAMKSLSEEFRPRTKSQSLSSTPISVPSRRHHPNPPPPSQVGISRRSRAETPIENSPVPKPHSLSKDYSVQSPEEEEEEKGARVETNESSADYGSASSDEYGSSPGVLEAPVFLPPSPGPRETNYISMALYGRRSLVMEPISTNANVPAEEGSRLTLFQEEDNYAMMGQREPRQETGYMPMLPGSNRSQDYMPMTPTSISPPAPVEMAGYVMMSPLGSCSPEIERLSWPPSQEVSAGSSDSHASDYMNMWSLSRSASSTPPPQEAFLSSPGGPCRVPASYRSLPRSYKMEPQPSARASCSSSSDSLEEVNAGKNRRPLSISIDSWNTGTLSGNYRRPPSPGEYVSIHFRAPPEEDLREGSHRCPKRVRFHGGAALGDAQRGLHGNGLCASQNFTTSCKNERGTGNERGKCLQTCGEITAGLGEDFLGEGLLGCR
What is the function of this protein?
May mediate the control of various cellular processes by insulin.  When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2.  Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
What are the official names of this protein?
Insulin receptor substrate 1, IRS-1.
Protein: ATPG_LACP3
Sequence: MAESLMDIKRKIASTKKTGQITQAMQMVSGAKLSQIEKRAKKYQIYSDKVRQIVTHLAAGQLLELANAAESDTDSGDKSQVISVASLLQKRPVKKTGYLVITSDRGLVGSYNSTVLKAMMQMIKDDHESPDDYVMMAIGGVGADFFKARGLNLAYEYRGVSDIPTFNEVREIVKTAVTMFDNGVFDELYVCYNHHVNTLTSAFRAEKMLPISDLDVSEVADTNVEYLIEPDLDSVLESILPQYAESLIFGAIMDAKTAEHAASTTAMRSATDNANDLISHLSTQYNRARQAAITTEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL1_CHLTB
Sequence: MTKHGKRIRGIQETYDLAKSYSLGEAIDILKQCPTVRFDQTVDVSVKLGIDPRKSDQQVRGSVSLPHGTGKVLRILVFAAGDKAAEAIEAGADFVGSDDLVEKIKGGWVDFDVAVATPDMMREVGKLGKVLGPRNLMPTPKAGTVTTDVVKTIAELRKGKIEFKADRAGVCNVGVAKLSFDSAQIKENVEALCAALVKAKPATAKGQYLVNFTISSTMGPGVTVDTRELIAL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.