PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_PYRAR
Sequence: MSALPAWLRVEARSYSEMAKVRSVLSRLGVYTVCEGARCPNVFRCWGEGTATFMILGEVCTRACRFCSVRTGNPRGYVDLDEPRRVAEAVRRLGLRYVVVTSVDRDDLPDGGAFQYASAIREIRRLAPGALVEVLTPDFRGSREAVETVAEAGPDVFAHNVETVRRLTPLVRDRRASYETSLRVLKTAKEVGCRLTKSGIMLGLGESFDEVVEVLDDLRKAEVDIVTIGQYVRPTKSARHLPVARWVPLEEFQKLGEVALSMGFKAVASAPLVRSSYRAEDLYEMALGLRPRAVLV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_AGRVS
Sequence: MKLNEIKDNEGSSKDRIRVGRGIGSGKGKTGGRGVKGQKARSGVAVNGFEGGQMPIYRRLPKRGFNNIFASEFTTVSLGRIQTAIDAGKLDASATIDAAALKAAGVIRRLKDGVRVLGDGELTTKVTIEVAGASKPAVEKIEKAGGTIKQLSAAAEKSE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: YCR41_YEAST
Sequence: MLKYVVTDIGKMCLYIWPYRVWSWRRLFIFRVLNVVSIAILFETPHRLALVPNVCLYTHMAIPLSTCLFCLCLCICIKYDITQTQANNQFLASFFVLILTINDLDVTFVI
What is the function of this protein?
May play a role in proper chromosome segregation.  Suppresses the high-frequency loss of mini-chromosomes when overexpressed, and this suppression is completely dependent on silencing protein SIR4.
What are the official names of this protein?
Uncharacterized protein YCR041W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FABH_MYCA9
Sequence: MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLTGAEIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSAGCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDRGNCFIFGDGAGAVVVGETAEQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVGQRAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALLIGYGAGLSYAAQVVRMPPVPFE
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG38_BPMD2
Sequence: MKTIAVLLLVVAFALGLTACDGGGSAPGYTGPNGVIFVPAGGGVNVPIFF
What are the official names of this protein?
Gene 38 protein, Gp38.
Protein: RL30_FRASN
Sequence: MAKLRITQIRSGIGGTRNQRETLRTLGLRKINASTVRDDRPEVLGMIATVTHLVRVEEVDS
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: PDCD1_HUMAN
Sequence: MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
What is the function of this protein?
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311).  The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311).  The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).
What are the official names of this protein?
Programmed cell death protein 1, Protein PD-1, hPD-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ZNUC_CHRSD
Sequence: MSLLSIAALDLALGGHLVLENVHLTLERGEIVTIVGPNGSGKTTLLKSIIGALTPQRGCIDKSPGMVIGYVPQRLHLDATLPMTVSRLMRLPRRRPTHEIETALDRAGVTQQASSQVSDLSGGQFQRVLLARALLSSPDLLILDEATQGLDQQGMADFYRQIERVRHELGCAVLMVSHELHVVMRASDRVICLNRSICCAGTPERVAASPAYRAMFGLDDEDALALYRHHHSRSSLEMSP
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NU6M_CAEEL
Sequence: MVKVFFVLAVLSSIISYINIDPMKSSFFLIFSLLFSMPVISMSMHIWFSYFICLLFLSGIFVILVYFSSLSKINVVKSYMAVFLLLLSMLYFSPTVLTYSSYLGLSGFYYSIYWFIFCFILVCLLFFMNFSSYFLNFSGALRKV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: VATB2_GOSHI
Sequence: GRIFNGSGKPIDNGPPILPEAYLDISGSSINPSERTYPEEMIQTGISTIDVMNSIARGQKIPFFSAAGLPHNEIAAQICRQAGLVKRLEKAGDLLEDGEEDNFAIVFAAMGVNMETAQFFKRDFEENGSMERVTLFLNLANDPTIERIITPRIALTTAEYLAYECGKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEGRKGSITQIPILTMPNDDITHPTPDLTGYITEGQIYIDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRRDHADVSNQLYANYAIGKDVQAMKAVVGEEALSSEDLLYLEFLDKFERKFVTQGAYDTRNIFQSLDLAWTLLRIFPRELLHRIPAKTLDQYYSRDAAN
What is the function of this protein?
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase subunit B 2, V-ATPase subunit B 2, Vacuolar proton pump subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: CAPP_CHRSD
Sequence: MSHDLHESLRDNVRILGDSLGRTIADDLGDGFVDKIETIRGLAKRGRQDDSESRRELIEYLRALPEKDLLPVTRAFNQFLNFSNIAEQHYRARFRRVEDYKPGTQPDLGELLERIRGAGHAPRKLVETLAAMRVELVLTAHPTEVIRRTLIRKYDAIDECLTTMEGATEREEIAARARGRLEELISQAWHTDEIRHERPTPVDEAKWGFAVIENSLWQAVPDFHRELDDLLLASAGERLPLDAAPLRFASWMGGDRDGNPNVTARVTEEVLLLGRWMAADLYARDLLRLKSELSMWKANGALRAEVGSDPEPYRALLKRLLARVEATRDWAKARLDGRPFDSNVAIIETRDQLYAPLLSCYRSLCDVGLDTIANGALLDTLRRVAVFGVSLTKLDIRQEAGRHAQVFDELSDCLGLGHYRDWDEAQRQDFLLEELESPRPLIPRRWDCSAETREVIDTFRVIAREHREALGTYVISMAGQPSDVLAVALLMKEVGGDLQLPIAPLFETLDDLNRAGDVIERLLSLPGYRRMAGDGQEVMIGYSDSAKDAGQLAAAWAQYRAQEQLVGICRQHDVALTLFHGRGGTVGRGGGPAHAAILSQPPGSVNGSLRVTEQGEMIRFKFGQPDIALRSMEIYACAVLEATLLPPPDPEPVWREEMDRLSDIAHRAYVGVVREDPDFVPYFRSVTPESALGRLPLGSRPAKRRQEGGVESLRAIPWIFAWTQTRLMLPAWLGSGEAFATRLDEPGGRERLRDMRARWPFFGTYLDMLEMLLAKADPDIAAYYERRLVDEPALQALGKSLRERLSRLETVLLDILDQDTLLEHTPLIRQAIEVRNPYIDPLHGLQAELLQRNRDADGAISPELSRALMVTMAGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: XENF_XENSI
Sequence: MSPAANMFRTLTLTALVSAVVSAYESQVPLNPQFPEYLNEEWDDSCSISKSTAYDVHDGPNTFSSSPSEDIHSVKISPHVNATNWEQWEFDGLSHTGLSGLLMAFSRDATYAFFGQGNLRVEFYITLGDGSIIQELDFISESYVIDCPDFTAGIWNSTDRSYSFYVTKDHQFARLKFDSWRVRGGFTMSSSTRPHLADGSPWTPDGGKPDATEVSPGLFYGLSMGGAEVDVDATLSSGKRITFKGRGGSTRLWATEGWLKLCDGWKVIRAWAGPYSIVYWDVLSRIDRGVRYVSGHLFYHDELLVGSRVGQPSDKADYVLFNDQFDGEMSGKYKDKNTGHHLEFASPARDKKWTFDVQHIVTQYEIGAGAGFGMSGFANRVVGGEVGGVQYEGKGQSEQTYWPEHIEEWKIWLVWGLGFLGRGKTYVMKLVGYVL
What is the function of this protein?
Hexane cyclase; part of the gene cluster that mediates the biosynthesis of xenoacremones such as xenoacremone A, a compound that shows inhibitory activity toward the PI3K/AKT signaling pathway and which has the ability to induce apoptosis of A549 lung cancer cells (PubMed:34900544).  Within the pathway, cooperation of the hybrid PKS-NRPS xenE and the trans-acting enoyl reductase xenG is responsible for the formation of the reduced tyrosine-nonaketide derivative (PubMed:34900544).  The alpha/beta hydrolase xenA then accelerates intramolecular nucleophilic attack to give a pyrrolidone derivative (PubMed:34900544).  Subsequently, three enzymes, xenF, xenD, and xenC, coordinately participate in the conversion to xenoacremone B (PubMed:34900544).  XenF catalyzes sigmatropic rearrangement to form an A-ring, which leads to an unusual intermediate with a hexane ring, which is required for the formation of the tricarbocyclic product (PubMed:34900544).  Epoxidation catalyzed by xenD and the formation of the paracyclophane ether catalyzed by xenC initiate a spontaneous intramolecular Diels-Alder (IMDA) reaction to yield xenoacremone B (PubMed:34900544).  Spontaneous hydration of xenoacremone B leads to the formation of xenoacremone A, which undergoes subsequent methylation to afford xenoacremone C (PubMed:34900544).
What are the official names of this protein?
Hexane cyclase xenF, Xenoacremones biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the Diels-Alderase family.
Protein: RUTF2_METEP
Sequence: MISSDPEAVSASAYREAMAQLASAVHLVTTDGPGGRAGLTATSVCSVSDGPPTLLVCLNRNSSAYPAFLRNGVLCINTLTAAHEGLATDFAGRVPQAERFAGPDWGRLQTGAPVLAGALVAFDCRIVDRHEVGTHDVLICAVEALAEISGAESLLYAGRHYRVLPRPDSESD
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF 2, FMN reductase 2, NADH-flavin reductase RutF 2, NADH:flavin oxidoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: I5P2_HUMAN
Sequence: MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
What is the function of this protein?
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
What are the official names of this protein?
Type II inositol 1,4,5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase.
What is the protein family that this protein belongs to?
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus.
Protein: RET4_HUMAN
Sequence: MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
What is the function of this protein?
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771).  Delivers retinol from the liver stores to the peripheral tissues (Probable).  Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).
What are the official names of this protein?
Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: C22L_VACCC
Sequence: MKSVLYSYILFLSCIIINGRDIAPHAPSDGKCKDNEYKRHNLCPGTYASRLCDSKTNTQCTPCGSGTFTSRNNHLPACLSCNGRRDRVTLLTIESVNALPDIIVFSKDHPDARHVFPKQNVE
What is the function of this protein?
The protein is truncated in this strain and presumably inactive.  It has similarities with variola virus CrmB, but the product is truncated due to several premature stop codon.
What are the official names of this protein?
Truncated CrmB protein.
Protein: LEUD2_DEIRA
Sequence: MPTVHVFARDHINTDEIIPARHLTTDVESELAKYAMEDYDKDFVRRVQPGDIIVAGADFGCGSSREHAVWALRGAGVSAVIAPNFARIYYRNSINNGFLALECEGITELFQDGEEAELDLKGGTIRNPRTGKELSFVPVPQFALDVQKAGGWLEYMKAGEDVEGERLDNASTSAGHGHAGTPLGDDPAKEDGPRPEQASGHQKEEHHA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit 2, Alpha-IPM isomerase 2, IPMI 2, Isopropylmalate isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: VL2_HPV27
Sequence: MPRAKRRKRASPTDLYRTCKQAGTCPPDIIPRLEQNTLADKILKWGSLGVFFGGLGIGTGSGTGGRTGYIPVGTRPTTVVDIGVAPKPPVVIEPVGASEPSIVTLVEDSSIINAGASHPTFTGTGGFEVTTSTVTDPAVLDITPSGTSVQVSSSSFLNPLYTEPAIVEAPQTGEVSGHVLVSTATSGSHGYEEIPMQTFATSGGSGQEPISSTPLPGVRRVAGPRLYSRANQQVQVRDPAFLERPADLVTFDNPVYDPEETIIFQHPDFHEPPDPDFLDIVALHRPALTSRQGTVRFSRLGRRATLRTRSGKQIGARVHFYHDISPVVPDELEMEPLLPPASTVGSDVLYDVYADPDVLQPLDDYYPAPRGSLANTTVSASSASTLRGSTTAPLSGGVDVPVYTGPDIEPPVVPGLGPLIPVAPSLPSSVYIFGGDYYLLPSYILWPKRRKRVNYFFADGFVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RPOZ_STRT2
Sequence: MMLKPSIDKLLDKVPSRYSLVILQAKRAHELAAGAEPTQEFSSVKYTLQALEEIESGNVIIHPNPEAKRKLARLKVIQARLAAEEEERKIKEQIAKEKEEGDKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RL7_STAAE
Sequence: MANHEQIIEAIKEMSVLELNDLVKAIEEEFGVTAAAPVAVAGAAGGADAAAEKTEFDVELTSAGSSKIKVVKAVKEATGLGLKDAKELVDGAPKVIKEALPKEEAEKLKEQLEEVGATVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FLIG_AGRFC
Sequence: MMDFEDFGNPLAGKPLSQADKAAAVLLAMGKGVAGKLLKFFTQHELQMIISSAQTLRVIPPDELAQIVAEFEDLFTEGTGLMDNAKAIESILEEGLTPEEVDSLLGRRAAFQAYEASIWDRLQEAEPEFVGKFLLREHPQTIAYILSMLPSSFGAKVLLTIPEEQRADIMNRTVNMKEVSPTAAQIIEKRVVNLINEIEAERNAGGSTKVADLMNELDKPQVDTLLSSLETLSKEAANKVKPKIFLFDDLMFMPQRSRVLLLNDVSADVLTMALRGATVEIKECVLSSISPRQRRMIESDLAVPQASLNTREVAIARRAVAQEAIRLANSGQIQLKDVAAEEQSAAA
What is the function of this protein?
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliG.
What is the protein family that this protein belongs to?
Belongs to the FliG family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Protein: HIS1_MARMS
Sequence: MSKTLTIALSKGRILGETLPLLEKANIVPVEDISKSRKLIFDTNHEHIKLVILRATDVPTYVDHGVADFGVAGKDVLMEASTKNLYELLDLKIAKCRLMTAGVVGQPLPNRRLKVASKFIKTAKAYFAEQGIQADVIKLYGAMELAPIMGLADLIVDIVDTGNTLKANGLEARELIAPISTRLVVNKAAYKTKYSEIEPILEMIRRAVEDNEGK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_BURL3
Sequence: MSFSRSAADAADTLPDLAATLGEPAVGAFVTLGDAFHTRLPAAPLAAPYVVGFSGEVAQLLDLPPSIAAQPGFAELFAGNPTRDWPANAMPYASVYSGHQFGVWAGQLGDGRALTIGERTGTDGRRYELQLKGSGRTPYSRMGDGRAVLRSSIREFLCSEAMHHLGIPTTRALTVIGSDQPVVREEIETSAVVTRVSESFVRFGHFEHFFSNDRPDLLRQLADHVIDRFYPECRRADDPYLALLEAATLRTADLVAQWQAVGFCHGVMNTDNMSILGVTIDYGPFGFVDAFDANHICNHSDTSGRYAYRMQPRIAHWNCYCLAQALLPLIGLQHGIDDDDARAERAVEDAQAVLAKFPERFGPALERAMRAKLGLELERESDAELANKLLETMHASHADFTLTFRRLAQISKHDASRDAPVRDLFIDRDAFDAWANLYRARLSEETRDDAARAAAMNRVNPKYVLRNHLAEVAIRRAKEKDFSEVERLAQILRRPFDEQPEHEAYAALPPDWAGSLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: LIS11_TALMQ
Sequence: MSRLLTIRQAEELHKSIIAYLSANNLSNAASALRGELGLSEEVFDTGTMVKYETLLEKKWTSIVRLQKKIMDLEARCGALQTELNNATPTSLSKRNQDPASWLPKVPARYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYGNTQSGVLLASCSSDLSIKIWNPLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARLWDITNISNPEAKLTMVGHDHVIECCAVAPQTSYQYLAPMAGLKKEALSKMSAVEFTATGSRDKTIKVWDRRGSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLSQDGKCVKTLSDAHGRFVTCLRWAPSVVKEVAPSAESANGQTDTNDLLKSKDNQPQVQIRCVVASGGVDQKLNIFAN
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein nudF 1, Lissencephaly-1 homolog 1, LIS-1 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: SLD5_HUMAN
Sequence: MTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPSSLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI
What is the function of this protein?
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293).  GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).
What are the official names of this protein?
DNA replication complex GINS protein SLD5, GINS complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the GINS4/SLD5 family.