PharMolix/UniProtQA huggingface dataset:
Protein: YIDC_CLOTE
Sequence: MSHLNNALVEFFVIIHKFISSIITNPNYSYGVAIIFVTLIIKLILLPLNIKSMRSTIRINEIQPEIQKIQKKYKNDPQRLQQEQMKLYKEYNINPFGSCLPLLLQWPILIALYYVFNNIQGISGVSFLWVKDLASPDIVLAVLAGATQYYSGLLMNPKGDNTQAKTASNMNLSMSIMMIFISSRLKAALVIYWVTGNLIQMGQTILTKKLEQKHSANKDA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL35_LIMRJ
Sequence: MPKMKSNRAAAKRFKRTANGGFKSGNSFTSHRFHGKTKKQRRQLRGLSMMDKTNVKRYKKLLPFK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y4243_SHEWM
Sequence: MKLVMVSGRSGSGKSVALRVLEDLGYYCVDNLPLPLMDTLLEQLKDSTELVAISVDVRNMHETELDKQLSNLPEGTELLSFFLNSSDEVLLKRYSETRRLHPLSRSKTSLKEAIDHERILLEPVSKLVDHYIDTSNLNIYDLSNQVREILLGSVDKELVINFESFGFKHGMPAEADFMFDVRFLPNPHWEPELRPMTGLDEPVQLFLSQQPTVNKFIWQIENLLETWLPHLERNNRSYLTIAIGCTGGQHRSVYVTEQLAKLFSQSKHTVQARHRELSND
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Swoo_4243.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RF3_STRPI
Sequence: MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILGIASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDDIELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLETFLKFAPEPHGHKKTDGEIVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNVTQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSAKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTSEYMLGAVGQLQFEVFKHRMEGEYNAEVVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDVELEEKM
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERD_RICBR
Sequence: MEFISQFLEMLLAERALSKNSILSYKRDLLDFHNYLAKQKLSELNITTDNIRNWVEYLAENSLQARSINRKISTIKSYYEFLISENHTNLNPLLNIDLPKYQNKLPEILSIDDIKSLLEYCSQDISPEGARLNAMIHLLYASGLRVSELVSLKLSDILSNKVSREVKKIFSVLGKGNKERIIVINEPAINSLVKYLVVRDNFVNKTKPKNLIYLFPSSAAAGYMTRQNFAILLKSAALYAGLNPEHISPHVLRHSFASHLLEGGADLRVIQELLGHADISTTQIYTHLQTNHLKKALLHHPLSKN
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_METI4
Sequence: MHQLGIEWNKLIAQIINFVIVLWVLNRFAFKPVLKILEERRKKIAESLQNAEKIKQELAEAEEARKEILRKANEQASFIVAEAQKVASYQGEKKIQEAVEEAKRVLKKAEESAKLEREKAKEEMRREILNLVIEITSKVVGKTLTLDDQERLKNEVLSKLPQKEGHEAYSRN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y2019_ACIBC
Sequence: MFGLFIITAIAEILGCYFPYLILKEGKSAWLWLPTALSLAVFVWLLTLHPAASGRIYAAYGGIYIFTALMWLRFVDQVALTRWDILGGVIVLCGAGLIILQPQGLIR
What are the official names of this protein?
UPF0060 membrane protein ACICU_02019.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YPT4_CAEEL
Sequence: MKLCHAIFSTFVVFFVASGAGEKQGESQLQQIYDELSILSRVTNAIALQAAALSKTVKIREVITELLKVDNGNFSNLLSLDPAHLVKNLDELHKKSLQAVSGSNEQLQQDLKEMIAMNGLLAAVESENYTEKATVNSLIVLKKVDEKMEICDESLITIMFNISQAMSGVPFAESDEMKIFSSMKTMKKAFYKCISKFPAFMQKLYEYNYPLSGFLELNDTMNTIKALNELDIANKIPNMLQKFKTPFLNILAVGDHRNKGNTGKLLQSAITLFKKTVYSNSSTRLFLTAGFPESGDMKRVAKDLTSDWFKKKVSRGKSTAELETALKPFNQFAESMAHVFKSWNNFRDDFQTDSALLATIPDLLSQIDDYDRNVDKKKFLENFEATFRTCFKNYKNALDQGEETKFLKNFSAVYLLVRSVQAVEQWASEISTMFDEKAMDVYFEELEKLTPSNIKEQVEKITNFDDFLKIINKFTMLKSLQTQYESAYKTSNSSELSLSKIITDAGLVDTSKCLEKDKLDSSKLLKMLQFMQHMMQLDIDYSTLKANLDNFFELKKKMLETEKLVKGFTSRSARAASNSGSPVLKIKDSQKHADHLGNGLLAIKKMIISLKEKATILKSTMFNAKANQEIREKNPIDYIKEFWTNPGPSIEKLVSDLEKLEQSSKSYRKADLLTIRKVFEDGSKIVGIPEVFSYIDSQFEKKGSQYSNERKITQALSTLDLNFASHKGALSAASLSVDNLKLYFDDLFGLTPKVSVQSESTSPIVVVLICVAIVLVLVILAIVGYGFTSNGRNQYINLYLYYFGKTSDYEKRWRYSLFMDRVDGKNVLIDSVREINATNLLKAVKRGAYINVCNKYGNTALHVATRRGYQNLVEILIKHGADRSFLNPQNKTAEQMIPVNYQETHKEKIERFKSIESIYNKYRKKKFKLCVPEKFPVSSFHIYIEDRTDDNVTNEFTTKFQSITSDEAMITTTHVVVKTTEDGILETDDLNLLIWIFHGSIIVRDTWMVDCLRDEKLIEKDCDYLVEKVKYKGIIYDTVTQWSNAMAKATTPFLYGVHVALCMKNCPYLASLTAIIQGQGGTMLDKFPDKDAFNKGSHPYLHKNLGPIFLLHDGTGDLDLYRSDPDKMFTLFTEQQFMDLLFKREINKDTNPKIIPVLVDEED
What are the official names of this protein?
Ankyrin repeat-containing protein F37A4.4.
Protein: PSAJ_GOSHI
Sequence: MRDLKTYLSVAPVLSTLWFGSLAGLLIEINRFFPDALTFPFF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VKT_BOMIG
Sequence: MNHKFIALLLVVLCCALAVHQVSAEVPSHCTLSLATGTCKGYFPRFGYNIEMGKCVEFIYGGCDGNANNFRNLEECQQSCSV
What is the function of this protein?
Serine protease inhibitor that inhibits plasmin (IC(50)=43. 53 nM, Ki=3. 6 nM).  Acts as an antifibrinolytic agent.  May act in a cooperative manner with the serine protease Bi-VSP (AC B5U2W0) to promote the spread of bee venom under anti-bleeding conditions.
What are the official names of this protein?
Kunitz-type serine protease inhibitor Bi-KTI.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: HXB4_HUMAN
Sequence: MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B4, Homeobox protein Hox-2.6, Homeobox protein Hox-2F.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLSX_HYDCU
Sequence: MSIKIAIDAMGGDHGIKVTVPASLEALSKFSDISIVLVGNQPLIEAELANHKYDKNRLSVEHAEQIVEMDDLPSKALRNKRKSSMRIALNLVKDDVAQACVSAGNTGALMAVSKFVLKTLPGIDRPAICTQMPTMKGHVHVLDLGANVGADGQSLAQFAVMGSVLAQAVDSNSRPRVGLLNIGEEEIKGHQRIKDANEILKSSDAINYVGYVEGDEIFKGDVDVVSCDGFDGNVALKASEGVAKMISFYLRAAFNKNLLTKLAGLVVYPVLKAFKAKVDPRRYNGASFLGLRKIVIKSHGGADVFSFYHAIAEARLEVNKNVPELIATEVKAILETH
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: FPG_XANCB
Sequence: MPELPEVETTLRGLAPHLVGQRIHGVILRRPDLRWPIAEQIEQLLPGATITDVRRRAKYLLIDTDAGGSAVLHLGMSGSLRVLPGDTPPRAHDHVDISLQNGRVLRFNDPRRFGCLLWQRDCETHELLASLGPEPLSPAFTGDYLHALARGRRAAVKTFLMDQAVVVGVGNIYAAESLHRAGISPLREAGKVSRERYRRLADAVKEILAYAIQRGGTTLRDFISPDGAPGYFEQELMVYGREGQACKHCGRELKHATIGQRATVWCAACQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: ATG7_NEUCR
Sequence: MDLKFATFSSEIELPFYSALFSSKLDHDKLDSSARPVLGLYEPRSHASPEASTRMQILGSALTSDQDESGPLGMTRAEGYIKNVNTIEEFKNTDKNAMIKKAGEQIWDAIQDGTIYSCPSLLASFRILSYADLKKYKFTYWFAFPALHSEPQWKRTGPIGRLTSDESTALVERIGTWRYMVDRREHGFFLAKKVRREAAGPRSSLDDPGVDIGYRWDIGSLRDFETGFFNDAAEEDRYVAFVDPSNYPEYPSWPLRNLLILIRQRYRLNKVQILCYRDTQPRRHEARSTILPLAMDQVGDVELKCMPKVTGWERNGNGDLRPRVANLAEYMDPTRLADQAVDLNLKLMKWRLAPNLDLDAIKNTKCLLLGAGTLGSYVSRNLLGWGVRKITFIDYGSVSYSNPVRQPLFKFEDCHNGGKPKAIQAAEALKEIYPGVDVEGYALSVPMLDHAIHNEAKTKADFDKLKELIDSHDAIFLLMDTRESRWLPTLMGKAANKIVMNAALGFDTYVVMRHGAAPNDGSEETLGCYFCNDVVVAADSMKDQTLDQQCTVTRPGVAAIASALLVELLTSILQHPLKQHAPAPVSTGTGSAVSYERDPPDHPLGLVPHQVRGFLSNFQNMVIRGKSYPQCSACSKPILDAYKEGGWEFVKTALASRDYVAELSGLAEVQRLAEKAAAEMQWSEDEEGMDEEEGEGELI
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates atg12 for its conjugation with apg-4/atg5 and apg-6/atg8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the apg-6/atg8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: VPB50_MYCTU
Sequence: MTSLLEVLGAPEVSVCGNAGQPMTLPEPVRDALYNVVLALSQGKGISLVPRHLKLTTQEAADLLNISRPTLVRLLEDGRIPFEKPGRHRRVSLDALLEYQQETRSNRRAALGELSRDALGELQAALAEKK
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin is VapC50.
What are the official names of this protein?
Putative antitoxin VapB50.
Protein: TRUA_AERS4
Sequence: MRIALGIEYDGSRYFGWQRQREVISVQAELEKALSRIANHPVSIQCAGRTDAGVHATGQVIHFDTHAIRSESAWTLGLNSNLPPDIAVRWVKEVDETFHARFSATARRYRYVIYNHNYRPAILGSGVSHYHETIDAALMHLAGQCLLGEQDFTSFRAIGCQSKTPWRNVTHLCVSRQGPYIVLDIRANAFLHHMVRNITGSLLLVGQGLKPVEWIAELLAAKDRNQAGPTAKAGGLYLVDVDYPAELALPQLPLGPLWLPDSAPGTTSF
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: KDUI_ECOSM
Sequence: MDVRQSIHSAHAKTLDTQGLRNEFLVEKVFVADEYTMVYSHIDRIIVGGIMPVTKTVSVGGEVGKQLGVSYFLERRELGVINIGGAGTITVDGQCYEIGHREALYVGKGAKEVVFASIDTATPAKFYYNCAPAHTTYPTKKVTPDEVSPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYFYFNMDDDACVFHMMGQPQETRHIVMHNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVKDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: GREA_STAAC
Sequence: MENQKQYPMTQEGFEKLERELEELKTVKRPEVVEKIKVARSFGDLSENSEYDAAKDEQGFIEQDIQRIEHMLRNALIIEDTGDNNVVKIGKTVTFVELPGDEEESYQIVGSAESDAFNGKISNESPMAKALIGKGLDDEVRVPLPNGGEMNVKIVNIQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RSMH_AZOVD
Sequence: MKSGFSHITVLLEEAVDALSIREGGCYLDGTFGRGGHSRLILGRLGAGGILLGFDKDPQAVAAGLALATEDARFVIVQRSFAELADEMKMRGLVGKVSGVLLDLGVSSPQLDDPERGFSFLNDGPLDMRMDPGRGLSAAEWLAQASCEEIAHVFKDYGEERFARRMAQAVVQRRQERPFERTADLAQVLAAANPAWEKGKNPATRAFQGLRIHINNELGDLEQGLDAALEVLEVGGRLAVISFHSLEDRIVKRFMRRQVKGEADKLPRDLPIRPAAFEPRLKLIGKPRYASESELKTNPRARSAIMRVAEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_THEPD
Sequence: MSLDELKLLEGQLLIPLEMYLAAGIRIGTKMKSKFMEPFIYSARPDGLYLLDVKKTDERIRIAAKMIARYDPSKFVVVSGRQYGHRPVRKFCGLVGCKPMLGRVLPGTFTNPALSHFTEADLMMVTDPRVDEQAVVEAGTMGIPVIALCDTDSPISNVDLIIPTNNRGRKALALIFWLLAREVLRIRGDIPPNGELPVPLSDFEARILTTGEVV
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: DNAK_PARDP
Sequence: MSKVIGIDLGTTNSCVAIMDGSQPKVIENSEGARTTPSIVAFTDSERLVGQPAKRQAVTNPSNTVFAVKRLIGRRTTDAEVEKDKKLVPYAIVDGGNGDAWVEVRGDKYSPSQISAFILQKMKETAESYLGEPVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKDSKTIAVYDLGGGTFDITILEIDDGLFEVKSTNGDTFLGGEDFDMRIVNYLADEFKKEHGVDLTKDKMALQRLKEAAEKAKIELSSSSQTEINQPFISMDKDSGTPLHMVMKLTRAKLESLVGDLIKRTMKPVQDALKDAGMSKGDIDEIVLVGGMTRMPKVVEEVTAFFGKEPHKGVNPDEVVALGAAIQAGVLQGDVKDVVLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQIFSTAEDNQNAVTIRVFQGEREMAADNKLLGQFNLENIPPAPRGMPQIEVTFDIDANGIVSVSAKDKGTGKEQKITIQASGGLSDDEIDRMVKDAEANAEADKQRKELVEAKNQAESLIHTTKKSLEEHGDKVDGSTVEAIELAVGALEEALKSEDAGKIKGGIQNLMDASMKLGEAIYKASQAEAGTGDAEGEAGPRDVDDEIVDADFEDLGEDKRK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: VP4_ROTD9
Sequence: MASLIYRQLLTNSYTVNLSDEIQEIGSTKTQNTTINPGPFAQTGYAPVNWGPGETNDSTTIEPVLDGPYQPTSFNPPVGYWMLLSPTAAGVIVEGTNNTDRWLATILIEPNVTSQQRTYTIFGVQEQITVENTSQTQWRFVDVSKTTQNGNYSQHGPLLSTPKLYAVMKYGGRIHTYSGQTPNATTGYYSATNYDSVNMTTFCDFYIIPRSEESKCTEYINNRLPPIQNTRNIVPLALSARNVISLKAQSNEDIVVSKTSLWKEMQYNRDITIRFKFANSIVKSGGLGYKWSEISFKPANYQYTYMRDGEEVTAHTTCSVNGMNDFSFNGGSLPTDFVISRYEVIKENSYVYIDYWDDSQAFRNMVYVRSLAANLNSVICTGGDYNFALPVGQWPYMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLAVEEPSFAIMRTRVSGLYGLPAANPNNGREYYEIAGRFSLISLVPSNDNYQTPIANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSIATNVMKKFKKSSLASSVSTLTDSLSDAASSVSRGSSIRSVGSSVSAWTDVSTQITDVSSSVSSISTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDKSIQISPNTLPDIVTEASEKFIPNRAYRVINNDEVLEAGTDGKFFAYRVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGIGKQQAFNLLRSDPRVLREFINQNNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: REX_THEAQ
Sequence: MKVPEAAISRLITYLRILEELEAQGVHRTSSEQLGELAQVTAFQVRKDLSYFGSYGTRGVGYTVPVLKRELRHILGLNRKWGLCIVGMGRLGSALADYPGFGESFELRGFFDVDPEKVGRPVRGGVIEHVDLLPQRVPGRIEIALLTVPREAAQKAADLLVAAGIKGILNFAPVVLEVPKEVAVENVDFLAGLTRLSFAILNPKWREEMMG
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLK_VIBPA
Sequence: MAWNEPGNNNGNNGRDNDPWGNNNRGGQRPGGRDQGPPDLDEVFNKLSQKLGGKFGKKGGGGSSIGGGGGAIGFGVIAIIAIAVWIFAGFYTIGEAERGVVLRLGKYDRIVDPGLNWRPRFIDEYEAVNVQAIRSLRASGLMLTKDENVVTVAMDVQYRVADPYKYLYRVTNADDSLRQATDSALRAVIGDSLMDSILTSGRQQIRQSTQETLNQIIDSYDMGLVIVDVNFQSARPPEQVKDAFDDAIAAREDEERFIREAEAYKNEILPKATGRAERLKKEAQGYNERVTNEALGQVAQFEKLLPEYQAAPGVTRDRLYIDAMEEVYTNTSKVLIDSESSGNLLYLPIDKLAGQEGQTDTKRKSKSSSTYDHIQLESERTQEETSNTQSRSTGTRQGRY
What is the function of this protein?
HflC and HflK could encode or regulate a protease.
What are the official names of this protein?
Protein HflK.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. HflK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SCPA_TRITO
Sequence: MRFAASIAVALPVIGAASAQGFPPPVEGVTVVKSKFDENVKITYKENDICETTEGVRSFTGHVHLPPDDNDFGVYRNYSINTFFWFFEAREDPKNAPLSIWLNGGPGSSSMIGLFQENGPCWINDDSKSTTNNTFSWNNKVNMLYIDQPNQVGFSYDELTNITYSTINDTVYVADFSNGVPAQNLSTLVGTGSSQNPWATANNTVNAARSIWHFAQVWFQEFPEHKPNNNKISIWTESYGGRYGPSFASYFQEQNEKIKNHTITEEGEMHILNLDTLGIINGCIDLMFQAESYAEFPYNNTYGITAYTKEKYDAIIHDIHRPDGCFDKLAKCREAAKEGDPHFYSNNATVNAICADASSSCDNYLMDPYQETNLGYYDIAHPLQDPFPPPFYKGFLSQSSVLSDMGSPVNFTQYAQAVGKSFHGVGDYARPDVRGFTGDIAYLLESGVKVALVYGDRDYICNWIGGEQVSLGLNYTGTAEFHRAGYADVKVNSSYVGGLVRQHGNFSFTRVFEAGHEVPGYQPETSLKIFERIMFNKDIATGELDIAQKPDYGTTGTESTFQVKNEIPPSPEPTCYLLSADGTCTQEQLKAIKEGTAVVENYIIKSPAASKGDPPPTTTTSPTAAPTAGSAMLQAPVAMLAISVLTALAFL
What is the function of this protein?
Extracellular serine carboxypeptidase that contributes to pathogenicity.
What are the official names of this protein?
Carboxypeptidase S1 homolog A, Serine carboxypeptidase A, SPCA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: ISPE_BACC4
Sequence: MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELTELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDELAELGAEIGSDVSFCVYGGTAIATGRGEKIEHIKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINSGDYKGICDTVGNVLEDVTFGMHPEVARIKSQMKRFGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: Y689_NITEC
Sequence: MTVPNHQQDISDSDLESRPSKTRLKQEMHALQVLGERLVELEPARITELDLPEKLTDALLEARRITSHGARRRQMQFIGKLMRAIDPVPVQEKLDAWQHSSLKHTAWLHQLERWRDRLISDEAAVTEFVQSYPQTDVRQLRTLLRNVEKEKLANKPPKSFRALFQLLRQIIPEISA
What are the official names of this protein?
UPF0307 protein Neut_0689.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.