PharMolix/UniProtQA huggingface dataset:
Protein: EFG_GEOSW
Sequence: MAREFSLENTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRINIIDTPGHVDFTVEVERSLRVLDGAITVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVKTLHDRLHANAHPVQLPIGAEDQFSGIIDLVEMCAYHYHDELGKNIERIEIPEDYRDMAEEYRNKLIEAVAELDEELMMKYLEGEEITKEELKAAIRKATISVEFFPVFCGSAFKNKGVQLLLDGVVDYLPSPVDIPPIKGIVPDTEEEVVREADDDAPFAALAFKVMTDPYVGKLTFFRVYSGTLDSGSYVMNSTKRKRERIGRILQMHANHRQEISKVYAGDIAAAVGLKDTTTGDTLCDEKNLVILESMQFPEPVISVAIEPKSKADQDKMGQALQKLQEEDPTFRAHTDPETGQTIISGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRKSAQVEGKFIRQSGGRGQYGHVWIEFSPNERGKGFEFENAIVGGVVPKEYVPAVQAGLEEAMQNGVLAGYPVVDIKAKLFDGSYHDVDSSEMAFKIAASLALKNAATKCDPVLLEPIMKVEVVIPEEYLGDIMGDITSRRGRVEGMEARGNAQVVRAMVPLAEMFGYATSLRSNTQGRGTFTMVFDHYEEVPKNIADEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_HALWD
Sequence: MPIEDRDNAYLITHALAKDTLSQLRDIETEQVAFRKGLVKLGRICGYEIIDGAMETEYAHVQTPLTETTGEQVSGLDNIVIVNVLRAATPFVEGLLKAFPRAKQGVISAGRDEAAGMNQDGMFPITIDYVKLPEITANDTVVVADPMLATGSTMCAVLDHVNDAAKSKPKNLFVLSAVSAPEGLLHVGSEFSSADLLTVAIDDYLDDEGYIVPGLGDAGDRAFRTV
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: IF3_PORGI
Sequence: MAIDKTKNQHRINEAIRVKEVRLVGDNVEQGVYNIQEARRIAESQDLDLVEISPNADPPVCRVTDYQKFVYQLKKKAKEQKAKSVKIVIKEIRFGPQTDDHDYNFKLKHAKEFLQEGSKVKAYVFFRGRSILFKEQGEVLLLRFANDLEDFARVEQMPILEGKRMTIMLTPKSASKKGHTPPKTQVEASKQANESAETEEE
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_JANMA
Sequence: MAQTLYDKLWQSHVVETGDDGTTVLYIDRHLLHEVTSPQAFEGLKLAGRRPWRVSANLMVADHNVPTTDRANGIADPTSRLQVETLDGNAHEYGLTYFSMRDKRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGCLAHGIGTSEVEHVLATQTLLAQKSKAMLVQVDGALPDGVTAKDIVLAVIGKIGTAGGTGYAIEFAGSTIRSLSMEGRMTICNMAIEAGARAGMVAVDDITINYVKGRPLSPVGPHWDRAVEYWRTLHSDAGAKFDLVVTLNAAEIKPQVSWGTSPEMVVAVDGRVPDPDKEKDPTKRDGMEKALIYMALKPNTPITDIRIDKVFIGSCTNSRIEDLRAAAAVVRGKYRASNVKLAMVVPGSGLVKEQAEREGLDKIFKAAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAGIEGHFVDVRALKH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: METK1_PICSI
Sequence: MDTFLFTSESVNEGHPDKLCDQISDAILDACLEQDPESKVACETCTKTNMVMIFGEITTKANIDYEKIVRDTCRGIGFVSADVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGARLTEVRKDGTCPWLRPDGKTQVTVEYKNEGGAMVPLRVHTVLISTQHDETVTNDEIAADLKEHVIKPVVPSQYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVAAGLARRCLVQVSYAIGVPEPLSVFVDTYGTGTGKIQDAEILKLIKENFDFRPGMISINLDLKRGGNMRFQKTAAYGHFGREDPDFTWETVKVLKWEKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_CHLT2
Sequence: MFIVVEGGEGAGKTQFIQALSKRLIEEGREIVTTREPGGCSLGDSVRGLLLDPEQKISPYAELLLFLAARAQHIQEKIIPALKSGKTVISDRFHDSTIVYQGIAGGLGESFVTNLCYHVVGDKPFLPDIIFLLDIPAREGLLRKARQKHLDKFEQKPQIFHQSVREGFLALAEKAPDRYKVLDALLPTEASVDQALLQIRALI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: POXO_PENOX
Sequence: MHRFFKSEFFNFEFIRILSAAPYGGAEIAECLVAAGQITNDDPESWHRAWIIQADKAKALGDEALHSGDTVSARRAYLRASNYYRASGYMFHDRPGAPDARVLPLAQQVLDTYALTLPLLDTGEASQLKIPFENHQLAAYLYLPRDRTKPVPVLLSLGGADSIQEELYYVYAASGPQLGYAVLTFEGPGQGITLRRDKMHMRPDWEVVVGRVLDFLTAYMQQNPSVQLDLSRVAVVGASMGGYYALRAAADPRIGACVSIDPFYDMWDFVRNHVSPALLNAWNAGWVPSRVVNGIMSMAMAASFQAKWEVGLAMWFFGVDSPTQTLRHMMKYTLARADGTSRLDQVKCPVLVSGATQSLYLEPESDVLRVFDALAHLGDERREIWIARSPEEGGLQAKIGAIGLVVQRTFRFLDQHLNVTR
What is the function of this protein?
Hydrolyase; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
Hydrolyase poxO, Oxaleimides biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: SNF12_ARATH
Sequence: MSGNNNNPQKPQGSAPLPFGNPGMASASVPGNQGFAQSHMAANFQAQFQFSQAQALAHAQAQSKVQAQLQAQLQAQGMTMNQAQGSPGIGGLGPSSPSLTTPGSLNMKRFQQKPPMRPPGAPASNNTISPMRTMELTPAARKKKQKLPEKSLQERVAAILPESALYTQLLEFESRVDAALTRKKVDIQEALKNPPCIQKTLRIYVFNSFANQNNTIPGNPNADPPTWTLKIIGRILEDGVDPDQPGFVQKANPLHPKFSSFFKRVTVSLDQRLYPENPLIIWENARSPAPQEGFEIKRKGNQEFAASIRLEMNYVPEKFKLSTALMDVLGIEVETRPRIIAAIWHYVKARKLQNPNDPSFFNCDAALQKVFGEEKLKFTMVSQKISHHLSPPPPIHLEHKIKLSGNNPAVSACYDVLVDVPFPIQRDLNNLLANAEKNKEIEACDEAICAAIRKIHEHRRRRAFFLGFSQSPVEFINALIESQSKDLKVVAGEASRNAERERRSDFFNQPWVEDAVIRYLNRRPAAGNDGPGSW
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
What are the official names of this protein?
SWI/SNF complex component SNF12 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMARCD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDL_CAUVC
Sequence: MTQQPQADAPLAGRHIAVLLGGPSSERKVSLVSGAACAEALERLGAKVSRIDPGPDVAQVLAATKPDMVFNALHGEWGEDGCVQGVLETLKLPYTHSGVLASALAMDKAKAKAVLAAAGVTVPGGGLFNRHDVARDHVLQPPYVVKPNAEGSSVGVFIIKEGANRPPEEVGAPSWTFGEEVMVEPYIQGMELAVAVLGESNGPRALAVTDIRASTGFYDYEAKYSEGGSIHVLPAPIPNAVRDRAMRMAELAHTALGCRGVTRSDFRYDDINDLLVLLEVNTQPGMTPTSLAPEQADHVGIPFDQLVLWIVEDAYARCSAGGTA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_CHLPD
Sequence: MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEMVNFLKIEQIVRELDIPLQVGGGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIYRPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMGIERVVYTDISKDGMMQGFGYESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNFEEDICIDHNFSTARKK
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRPSB_DICDI
Sequence: MSNNRLVILHGNAHPKLSKEIASCLNTEVGNALVSKFANSETQVIINESVRDVDLYIVQPTCNPSVNDYLMELLVMVDGAKRASAHRITAVVPFFGYARQSKKDKSRAPITCKLVANMMEAAGIDRVITMDLHSSQIQGFFNIPVENVYTEPLFVKYIKKKKKTEFLNQEFVIVSPGVGGVKRAKAISDKLESELAIIHRANKEMSLSLSSSFSFDIEETVLVGDVTGKIAIIIDDIADTCKTLKLASKALIKKGAIKVYALVTHGVFSNNAIDIINDSSITELVITDSIPNEHNKEKCPKLKIISIASVLSETMRRCHHGESVTSISK
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase B, Phosphoribosyl pyrophosphate synthase B.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDSP4_ARATH
Sequence: MTLESYAGDVHTVPQSENSMEERGGGELFVPPLNFAMVDNGIFRSGFPEPVSFSFLQSLRLKSIIYLCPEAYPEVNREFAKSNGIQVFQFGIERCKEPFVNIPDEVIREALQVLLDTENHPVLIHCKSGKHRTGCLVGCVRKIQRWCLSSIFDEYQRFAAAKARISDQRFMELFDISNLKHTPLSFSCSKRYTNTIDY
What is the function of this protein?
Probable tyrosine-protein phosphatase that acts as negative regulator of defense responses against the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000.
What are the official names of this protein?
Probable tyrosine-protein phosphatase DSP4, Protein PLANT AND FUNGI ATYPICAL DUAL-SPECIFICITY PHOSPHATASE 4, AtPFA-DSP4.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: ZN564_HUMAN
Sequence: MDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECGKAFNYASSIRIHERTHTGEKPYECKQCGKTFSYSSSFQRHERAHNGDKPYVKNVGKLSFITQPSNTCENE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 564.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KL98A_DROME
Sequence: MSSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTHYEYEVRIALPDGKLNILRRYSRFRELHLCMKHCYGAKISALPFPRRELFASNSEPVAKHRRRLLELYLRRLFVVCSKIPQCPIYEGPGGTGLTRASLVQLSSFFKKGLFENGKHGTG
What is the function of this protein?
Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell.  Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division.  During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188).  Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14 (PubMed:26763909).
What are the official names of this protein?
Kinesin-like protein Klp98A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Early endosome.
Protein: DNJ63_ARATH
Sequence: MVRTRLAISVVLVSTLLLLNVKAKSVDPYKVLGVSKDAKQREIQKAFHKQSLKYHPDKNKDKGAQEKFAEINNAYEILSDEEKRKNYDLYGDEKGQPGFDSGFPGGNGGYSYSSSGGGFNFGGPGGWQNMGGGGGSKSFSFSFGGPSESSFGFGMDDIFSMFSGGSSKGKEQFGGFGSSSNAESKSKSSTVAAIKTINSQVYKKDVVDQGMTWLLLSYLPSQRGSQYHESIIEEVAESLQGALKVGRLNCETESSLCKQLGIVPRRAPRMFVYSYTSSGKATLAEYTEELVAKKVKSFCQEHLPRFSKKIDLNTFDVSAVSSQKTPKVLLLSTKKDTPVIWRVLSGLYNGRFVFYNTEVHDTSDPKIQKLGVDKFPAIVGWLSNGEKQVLKTGITVKNLKSAVQELGKLLEGLEKKNKKVSSKSQAGQAPNESSEKIPLLSRPNFDSICGENTPVCIIGAFRSSNGKEKLQSIMSKVSQKSLSRRQASTTGSQDTVSYSLLDATKQSAFLSSLDKSEFKTSSDKLLIAYKPRRGKFATFKGDMTIEEVEKFVAAVLNGDIQFTKTRQKPQIK
What is the function of this protein?
Regulates protein folding in the endoplasmic reticulum (ER) lumen.  Functions probably as a co-molecular chaperone that is required for normal growth of pollen tubes under high-temperature stress.
What are the official names of this protein?
DnaJ protein ERDJ3A, Chaperone protein dnaJ 63, AtDjA63, AtJ63, Endoplasmic reticulum dnaJ domain-containing protein 3A, AtERdj3A, Protein SCJ1 homolog ERDJ3A, Protein THERMOSENSITIVE MALE STERILE 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: UPPP_BRUAB
Sequence: MDFFNLLEAAFLGLIEGLTEFIPVSSTGHLLLIGHFLGFESTGKTFEVLIQLGAILAILSVYSAKLARIATDFPRDARTRRFVLGVLVAFLPAAVIGALAHGFIKGVLFETPMLVCIMLIVGGFILLWVDQLNLRPRYHNVMDYPLPICLAIGFIQCLAMIPGVSRSGSTIVGSLLLGADKRSAAEFSFFLAMPTMAGAFAYDLFKSRNILSFNDGALIVVGFIMAFISGVFVVRHLLDYVSRHGFALFGWWRLIVGSAGMAALIIWG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLYA_HELMI
Sequence: MSEWKHLHQVDPEVAAAMDREKKRQKNNIELIASENFVSEAVMEAAGSVLTNKYAEGYPGKRYYGGCEFVDQVERLAIERAKRLFGAEHANVQPHSGANANMGVYFACLEPGDTVLGMNLAHGGHLTHGSPVNISGKYFRFVAYGVDAHTGRIDYDEVARIARETKPKLIVAGASAYPRVLDFARFRAIADEVGAMLMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCKQEWAAKVDKAIFPGLQGGPLMHIIAAKAVAFQEAMAPAFTAYQKQIAANAAALAKGLTDRGFQLVSGGTDNHLMLVDLRNKQLTGKEAEKRLDECRITVNKNAIPFDPQSPFVTSGIRIGTPAATSRGMDEAAMDQVAEAIHLCLSDGSEGAMQKAVAIVDALCARFPLYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECE_BACSU
Sequence: MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFALLDTGISQLIRLIVE
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ISPD_CHLPM
Sequence: MNATAIIAASGVGKRMNLGGGRSKQMLEIGGFPVIHHTIKAFQEAASIKAICIATKAEHVETLRTMAREAGFTKVTTVIEGGEERQDSVGNCIRSIRDEAAAGKEMPEAILVHDGARPFIQPDEIDAIAALSLEYGASVPANRPKDTIKCIGTTPGFFGETLDRATLLQVQTPQGFKADILIKAHEQAAKEGRYATDDAALVERYFPANPIRIYETGYHNIKITTPEDLPMAEAIYSSLSKKR
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PRP8_MOUSE
Sequence: MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPSQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
What is the function of this protein?
Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome.  Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs.  Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome.  Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur.  Interacts with both the 5' and the 3' splice site.
What are the official names of this protein?
Pre-mRNA-processing-splicing factor 8, Splicing factor Prp8.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: QUEA_ECO27
Sequence: MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDERINATMTARHGALFEVEFNDQRSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.