PharMolix/UniProtQA huggingface dataset:
Protein: SYE_PSEPW
Sequence: MTTVRTRIAPSPTGDPHVGTAYIALFNYCFAKQHGGEFILRIEDTDQLRSTRESEQQIFDALRWLGIEWNEGPDVGGPHGPYRQSERGEIYARYAKQLVDAGHAFYCFCTAEELEQMRAEQMARGETPRYDGRALLLSDEEVQRRLAAGEPHVIRMKVPSEGICVVPDMLRGDVEIPWDRMDMQVLMKNDGLPTYFLANVVDDHLMGITHVLRGEEWLPSAPKLIKLYEYFGWEQPKLCYMPLLRNPDKSKLSKRKNPTSVTFYERMGFMPEAMLNYLGRMGWSMPDEREKFSLAEMVEHFDLSRISLGGPIFDIEKLSWLNGQWLRELPVEEFAARVQKWAFNSDYMMKIAPHVQGRVETFSQIAPLGGFFFEGALKLDAKLFESKKLSADQVRQVMQLILWKLESLRQWEKERITGCIQAVVEALELKLRDAMPLMFAAITGQASSVSVLDAMEILGPDLTRYRLRQALDLLGGVSKKENKEWEKLLANIA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF276_BOVIN
Sequence: MPLTRDPFQNPALDKDDSYLGKSRASKKLPYKNPTHLAQQQEPWCRLSSTPTITSMKRDGFFFYSEIPKDDLDFRLAALYNHHTGTFKNKSEILTHQETIQDTRRIKTQFPGEFLPAPQPPLITSRANIRHWINPKKESIHSIQGSIVSPHTAATNGGYSRKNDGGFFST
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025).  May play an important role for the maintenance of myelin-axon integrity (By similarity).  May affect intracellular Ca(2+) homeostasis (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 276.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RS7_BACAA
Sequence: MPRKGPVAKRDVLPDPMYNSKLVTRLINKMMVDGKKGKSQTILYNAFDIVSERTGKEPMEVFEQALKNIMPVLEVRARRVGGANYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEERLANEILDAANNAGASVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LNAE_ASPFN
Sequence: MTRVTMDQDTENKVLVIKNMDSGYLVAGEQVTLEDVSYDATEPLAEDELMVQLLYATYDLFKRDLASSSADATELRGRKPVETMSIAQVIKSNNKQFQEGDMVIGRLPVQQYVLIKADDATELKLLENPCEFDDIRLFLSVLGVPGLLAFSSLYEIGRPKKGETILIAGASDEIGQLVGQMARLEGLKVFGSVESDEKLDFLITELGFDGGFNYAKESPYEALPRLVPNGIDIYYDNLSWMSRLNIGGLDTHFDLLGSRHLNAAFSSMRRYGRIMFYGTIAEQTVLDPIIGMFLHNTVLKRLTIRGFGLSDPSFGKKWGKLHMERMQQWVKEEKLKIPTFEITGMDNAAKAFVEAFYSSENTHTHTILAVT
What is the function of this protein?
NADP-dependent oxidoreductase; part of the lna gene cluster that mediates the biosynthesis of diastereomeric piperazines.  Lna and lnb clusters encode sets of enzymes that produce overlapping sets of previously undescribed metabolites such as piperazinomycin-like metabolites or morpholine (PubMed:23281040).  The lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure (PubMed:23281040).  One primary function of the non-canonical nonribosomal peptide synthetases lnaA and lnbA consists in the reduction of L-tyrosine (PubMed:23281040).  The presence in the clusters of tailoring enzymes such as the oxidoreductases lnaB, lnbB, lnaE or lnbE, as well as of the cytochrome P450 monooxygenases lnaC, lnaD, or lnbC, might explain formation of various diastereomeric piperazines (PubMed:23281040).
What are the official names of this protein?
NADP-dependent oxidoreductase lnaE, Lna diastereomeric piperazines biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the NADP-dependent oxidoreductase L4BD family.
Protein: RS6_SHEPW
Sequence: MRHYEIVFLVHPDQSEQVPGMIERYTGILTQAGGQIHRLEDWGRRQLAYPIIELHKAHYVLMNVETTAESVEELETAFRFNDAVLRSMVMRTKAAITEASPMAKAKDERDTRRSSEERAPRAEATEEVKESAENTAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SH3G1_HUMAN
Sequence: MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLPQ
What is the function of this protein?
Implicated in endocytosis.  May recruit other proteins to membranes with high curvature (By similarity).
What are the official names of this protein?
Endophilin-A2, EEN fusion partner of MLL, Endophilin-2, Extra eleven-nineteen leukemia fusion gene protein, EEN, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the endophilin family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein. Cell projection, podosome. Note=Associated with postsynaptic endosomes in hippocampal neurons.
Protein: LYTA_BACSU
Sequence: MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVGLADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN
What is the function of this protein?
Possible role in the secretion of LytB and LytC.
What are the official names of this protein?
Membrane-bound protein LytA.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SFNF_PSEPU
Sequence: MNTSVIRVVVVSGSLRAPSRTHGLLQALVEKLQARLSNLDVHWVRIAELCSALSGSLERDTASADLQLHLQAIEQADLLLVGSPVYRASYTGLFKHLFDLVDHQSLRGVPVVLAATGGSERHALMIDHQLRPLFAFFQAHTLPYGLYASVEAFDQHHLVEPAQFERIERVLDTVSAFFQIPVASAA
What is the function of this protein?
Involved in the dimethyl sulfide degradation pathway.  Catalyzes the NADH-dependent reduction of FMN.
What are the official names of this protein?
NADH-dependent FMN reductase SfnF, NADH-flavin reductase.
What is the protein family that this protein belongs to?
Belongs to the SsuE family.
Protein: FLBT_RHIE6
Sequence: MKSTLRISLKAGERIFINGAVLRVDRKVALEFLNDVTFLLENHVLQPEGATTPLRQLYFIAQMILINPEGKDHSTAMFRKSITMLLTCFKNEEILAELKRIDALVSTGRAFDALKAIRGLYAIEDNILNNHELPPTMVEQIRREIAPWR
What is the function of this protein?
Has a post-transcriptional repressor function in flagellum biogenesis.  Associates with the 5'-UTR of fljK mRNA and promotes its degradation.
What are the official names of this protein?
Probable flagellum biosynthesis repressor protein FlbT.
What is the protein family that this protein belongs to?
Belongs to the FlbT family.
Protein: EX7S_GLUOX
Sequence: MPEPIDAMSFEDALSELERIVRGLEGGQMKLEDAISAYERGAALRRHCDAKLGEAEMRVRAIVQNDDGTTGTEPLADTGESGR
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC181_MACFA
Sequence: MNEIKDTDSKKSEEYEDDFEKDLEWLINENEKSDASIIEMACEKEENINQDLKENETVIEHTKQHSDPDKSLQDDVSPRRNDIISVPGIQPLDPISDSDSENSFQESKLESQKDLEEEEDEEVRRYIMEKIVQANKLLQNQEPVNDKRERKLKFKDKLADLEVPPLEDTNTSKNYFENERNMFGKLSQLCISNDFGQENVLLSLTNASCEENKDRTILVERDGKFELLNLQDIASQGFLPPINNANSTENDPQHLLLRSSNSSVSGTKKEDSAAKIHAVTHSSTGEPLVYIPQPPLNRKTCPSSAANSDRSKGKGKYNHRTQSARISPVTSTYCLSPRQKELQKQLEQKREKLKREEEQRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRRIQRAKEIEDMNSRQENRDPQQAFRLWLKKKHEEQMKERKTEELRKQEECLFFLKGTEGRERAFKQWLRRKRIEKIAEQQAVRERTRQLRLEAKHSKQLQHHLYMSEAKPFRFTDHYN
What is the function of this protein?
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
What are the official names of this protein?
Coiled-coil domain-containing protein 181.
What is the protein family that this protein belongs to?
Belongs to the CCDC181 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localizes to the microtubular manchette of elongating spermatids. Localizes to the sperm flagella and to the basal half of motile cilia.
Protein: GLYG2_HUMAN
Sequence: MSETEFHHGAQAGLELLRSSNSPTSASQSAGMTVTDQAFVTLATNDIYCQGALVLGQSLRRHRLTRKLVVLITPQVSSLLRVILSKVFDEVIEVNLIDSADYIHLAFLKRPELGLTLTKLHCWTLTHYSKCVFLDADTLVLSNVDELFDRGEFSAAPDPGWPDCFNSGVFVFQPSLHTHKLLLQHAMEHGSFDGADQGLLNSFFRNWSTTDIHKHLPFIYNLSSNTMYTYSPAFKQFGSSAKVVHFLGSMKPWNYKYNPQSGSVLEQGSASSSQHQAAFLHLWWTVYQNNVLPLYKSVQAGEARASPGHTLCHSDVGGPCADSASGVGEPCENSTPSAGVPCANSPLGSNQPAQGLPEPTQIVDETLSLPEGRRSEDMIACPETETPAVITCDPLSQPSPQPADFTETETILQPANKVESVSSEETFEPSQELPAEALRDPSLQDALEVDLAVSVSQISIEEKVKELSPEEERRKWEEGRIDYMGKDAFARIQEKLDRFLQ
What is the function of this protein?
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
What are the official names of this protein?
Glycogenin-2, GN-2, GN2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
Protein: UREE_CERS4
Sequence: MTELPQARRLLKQGEWTGPAAGCVRLGYDERFLRRKRLETEAGDGFLVDLAETTSLDEGCAFELADGRLVEVRAAEEEVVAVTGPILRAAWHIGNRHTPCQIEADRLVIRRDHVLEEMLRGLGLTLEPRTEPFRPEGGAYGHGRTLGHDHGPAQGHGHDHPHVHVHISHKPDEDETPDADPA
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_MYCMS
Sequence: MKVIIGLGNIGKEYEKTRHNAGFIAIDLLLEKYNYSSVKQEFNSLIYTTIINNQKVLLVKPLTFMNNSGLAVRQIINFYKINLNDLIIIHDDKDLNISRIQFKKDGSSAGHNGIKSIINNLQTQNFYRLRIGVNQVPKEWKIVDWVLSKFSDEELNLLKQSFIDKIEFINDFTNNKTFIYLMNKYN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD_BATMU
Sequence: YLVSPAAYAALGAYMFLLILIGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAIERWIVVCKPISNFRFTEDNAIMGLAFSWVMALTCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFPIPLSVIFFCYGRLLCAVKEAAAAQQESETTQRAEKEVSRMVVILVIGFLVCWLPYASVAWWIFCNQGSDFGPIFMTLPSFFAKRPAIYNPMIYICMNKQFRHCMI
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: DPOA2_MOUSE
Sequence: MAVSTQQLAEELQIFGLDYEDSLLEKLAELCVLYRQTEDGMVSELIAFCTSAGKTCLTVDILNSFEYEVLNKKLSKAWHSASKDSGHAGTRDIVSIQELIEAEEEEETLLSSYTTPSKGPLKRVSSTPETPLTKRSVAARSPRQLLSPSSFSPSATPSQKYTSRTNRGEVVTTFGSAQGLSWSGRGGSGSVSLKVVGDPEPLTGSYKAMFQQLMGVREVLTSKIEELGSELKEHHKIEAFTPLLVPAQEPVILLGQIGCDSNGKLNSKSVILEGDQEHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPLPFYQPTEEEGASEQTMVVVACGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQVENCKLTSPFEDVFKQCLRTVIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFTFSELSREDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIGAEEIFSSSGTSDRFSRVLKHILTQRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVKDIFGCVCVNPGRLTKGQVGGTFGRLYLRRQPKAMDGGGRQGLSVAAQVVRI
What is the function of this protein?
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.  These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).
What are the official names of this protein?
DNA polymerase alpha subunit B, DNA polymerase alpha 70 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase alpha subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METXS_BURA4
Sequence: MESIGIVAPQTMHFAEPLRLQSGSVIGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNLVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPSSGKPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLMYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPKRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFSFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFDGNLTAALAHTQAKYLIASFSTDWRFAPARSREIVKALLDNKRTVSYAEIDAPHGHDAFLLDDARYHNLLRAYYERIANEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_ACIB3
Sequence: MAGLSIWHVVIFAIVVILLFGTSKLKNIGKDVGGAVRDFKKSVREEDEAASLNSPRTIDAQVKTSESTSVKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RWDD1_HUMAN
Sequence: MTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLKFTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFTLVTAVQEKLNEIVDQIKTRREEEKKQKEKEAEEAEKQLFHGTPVTIENFLNWKAKFDAELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEMDDLELEDDEDDPDYNPADPESDSAD
What is the function of this protein?
Protects DRG2 from proteolytic degradation.
What are the official names of this protein?
RWD domain-containing protein 1, DRG family-regulatory protein 2.
What is the protein family that this protein belongs to?
Belongs to the RWDD1/GIR2 family.
Protein: Y236_BEII9
Sequence: MIVHIPAVLNAEQIARCRAVMQTGDWIDGRVTAGHQSRLVKNNLQLPESSPEHQELGEMIVRALWHNPLFISAVLPHTIFPPLFNRYDVGMGFGTHVDTAVRRNLDGSLRIRTDVSATLFLAGPEDYDGGELTIEDTYGTHSVRLPAGDLIIYPADSLHFVSPVTRGSRIASFFWIQSLIRDKTQRNLLFNLDTAIMRLTEDVAGNPALVSLQGVYHNLLRQWAEI
What are the official names of this protein?
PKHD-type hydroxylase Bind_0236.
Protein: FTSZ_RICFE
Sequence: MVLNIKAPENIVLKPTITVFGVGGAGSNAVNNMISANLQGANFVVANTDAQSLEHSLCTNKIQLGVSTTRGLGAGASPEVGALAAQESESEIRSYLENSNMVFITAGMGGGTGTGSAPVIARIAKELGILTVGVVTKPFHFEGGHRMKTADKGLIELQQFVDTLIVIPNQNLFRIANEQTTFADAFKMADDILHAGVRGVTDLMIMPGLINLDFADIKAVMSEMGKAMMGTGEASGEDRAIKAAESAISNPLLDHSSMCGARGVLINITGGSDMTLFEVDNAANRIREEVDNLDANIIFGSTFNPELKGIIRVSVVATGIDADKVPTYKPAIAETTNIVPEETYNEPIVQPTQIEEIPDFNSYSTENIEITDSPINQNFIGNEKELGLHANSFNKSEDDSPKPSFLGKIWGSLRASNNQTLERKNIVVNTLDQDNKESDIHDIPAFLRKKRD
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: ZN75D_HUMAN
Sequence: MAMRELNADSCSSPQMGAMWETSGSVKENSSQSKKYSTKIENLGPESACRHFWSFRYHEATGPLETISQLQKLCHQWLRPEIHSKEQILEMLVLEQFLSILPKETQNWVQKHHPQNVKQALVLVEFLQREPDGTKNEVTAHELGKEAVLLGGTAVAPGFKWKPAEPQPMGVFQKEYWNTYRVLQEQLGWNTHKETQPVYERAVHDQQMLALSEQKRIKHWKMASKLILPESLSLLTFEDVAVYFSEEEWQLLNPLEKTLYNDVMQDIYETVISLGLKLKNDTGNDHPISVSTSEIQTSGCEVSKKTRMKIAQKTMGRENPGDTHSVQKWHRAFPRKKRKKPATCKQELPKLMDLHGKGPTGEKPFKCQECGKSFRVSSDLIKHHRIHTGEKPYKCQQCDRRFRWSSDLNKHFMTHQGIKPYRCSWCGKSFSHNTNLHTHQRIHTGEKPFKCDECGKRFIQNSHLIKHQRTHTGEQPYTCSLCKRNFSRRSSLLRHQKLHRRREACLVSPN
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 75D, Zinc finger protein 75, Zinc finger protein 82.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GGR1_METST
Sequence: MLKTDVVVIGAGPAGSMAAKHAALGGANVVLIDKKSEIGTPKRCAEGVYDEGFKWLNIEPDERWIAQRIYGATLHSPDGNSFTVTSEDVPVQGFILERKVFDKHMAMDAARAGAKIMIKTLVTDIKRNENGFILSCDSIEGTIEVEAKIAICADGPESIMAKKLGINSTTPQNMMSCAQFEMCNVDYNDDEKIEFYLGQDVALKGYAWIFPKGNGVANVGLGVTGNTDKTAYEYIMDFIEKCPATKNAQPIEMNIGGDPINGLIEKIYDDNLLICGDAAGQVNPIEGGGIIEGMLGGMAAGDVAAKAIKEENYSKERLHEYYEKYSELSFNLIETLPAARDIVYSFTDDEYNKIISVANTIDLKNISKRDVLKVVFKLPPTLTTKLIKLLKIVFPKQMKSILF
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase 1, DGGGPL reductase 1, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase 1, Geranylgeranyl reductase 1, GGR 1.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Protein: LIS1_LACTC
Sequence: MSLLPPEQRQLLHRCILNYIRSQVPGDGAEGETGGQTEERHVMNSLAKWLRVDPDGLDGEKAADGSLLPRKWSSIVRLQRRIIELEKEIQELTDENENLRENGPSSPANGALKSWLPRERPSFSISAGASVTSVKLHPELPLVFIATDAGKLQCYDLMNYTMPVASVQAHMRGITAIDAYVGEDSQCLVATASKDLHCKVFRFVDSELQLIRTLSGHEHIVSHIKIWNNSTNTLVASCSRDLTCKVWDIANGWCLKSFQPHTEWVRCLDVMGDFVVTGSNDCTVRLSHWPTGRSLSFGTGHEFPVEKIRIIPLQPPESAEHSHRFNTHDEDYLPLGFSHVISTSRDGTLRIWQVPLPRFVAHRAPQPNPARPYFNLVATLKGHSSWVRDVRVRGKHAFSCSDDRSIKVWDLSTCEVVRSINNLHSGFINCIDIDCGGLNRQLLVSGGADGKLVILMK
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  Plays a central role in positioning the mitotic spindle at the bud neck during cell division.  Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles.
Protein: GRIA2_RAT
Sequence: MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
What is the function of this protein?
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.  The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.  In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.  Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816).
What are the official names of this protein?
Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).