PharMolix/UniProtQA huggingface dataset:
Protein: DISA_MYCBT
Sequence: MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: PIF3_ARATH
Sequence: MPLFELFRLTKAKLESAQDRNPSPPVDEVVELVWENGQISTQSQSSRSRNIPPPQANSSRAREIGNGSKTTMVDEIPMSVPSLMTGLSQDDDFVPWLNHHPSLDGYCSDFLRDVSSPVTVNEQESDMAVNQTAFPLFQRRKDGNESAPAASSSQYNGFQSHSLYGSDRARDLPSQQTNPDRFTQTQEPLITSNKPSLVNFSHFLRPATFAKTTNNNLHDTKEKSPQSPPNVFQTRVLGAKDSEDKVLNESVASATPKDNQKACLISEDSCRKDQESEKAVVCSSVGSGNSLDGPSESPSLSLKRKHSNIQDIDCHSEDVEEESGDGRKEAGPSRTGLGSKRSRSAEVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKSLQLQVQIMSMASGYYLPPAVMFPPGMGHYPAAAAAMAMGMGMPYAMGLPDLSRGGSSVNHGPQFQVSGMQQQPVAMGIPRVSGGGIFAGSSTIGNGSTRDLSGSKDQTTTNNNSNLKPIKRKQGSSDQFCGSS
What is the function of this protein?
Transcription factor acting in the phytochrome signaling pathway (PubMed:10466729, PubMed:14508006).  Activates transcription by binding to the G box (5'-CACGTG-3') (PubMed:10797009).  Acts as a negative regulator of phytochrome B signaling (PubMed:14508006).  Represses chlorophyll biosynthesis and photosynthesis in the dark (PubMed:23548744).  Recruits the histone deacetylase HDA15 to the promoters of chlorophyll biosynthetic and photosynthetic genes (PubMed:23548744).  HDA15 represses their transcription by histone deacetylation (PubMed:23548744).  Promotes the expression of MDP60 to modulate hypocotyl cell elongation in response to light and ethylene signaling (PubMed:29167353).  Required for submergence-induced and ethylene-dependent underwater hypocotyl elongation (PubMed:31638649).
What are the official names of this protein?
Transcription factor PIF3, Basic helix-loop-helix protein 8, AtbHLH8, bHLH 8, Phytochrome-associated protein 3, Phytochrome-interacting factor 3, Transcription factor EN 100, bHLH transcription factor bHLH008.
What are the subcellular locations of this protein?
Nucleus.
Protein: HAKAI_MACFA
Sequence: MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEGFDYNEEERYDCKGGELFGNQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1.  Targets CDH1 for endocytosis and degradation.  Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.  Its function in the WMM complex is unknown.
What are the official names of this protein?
E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1, c-Cbl-like protein 1, RING-type E3 ubiquitin transferase Hakai.
What is the protein family that this protein belongs to?
Belongs to the Hakai family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Protein: FIGL1_CAEBR
Sequence: MYSPKRVKLNLTNGMRKRPETEENRGELYPPTAMARNGISPYFIGKPRRKIVGDHKASEAGPPPPFPLKPKRKEPDDDPESIVIDEDDEEDEPAPQVEKREPKKTHNRPFFGEKSSLTATELETAKKEEVVKKKDPFTMRGFDFGSDEKVVKIRDKICDIVDPTGARRSDPAFIQQMHSNTLKGIEVATNPKFKQKRTANNKNRAAIGSTLGTIYPNFLTASGQEPQKSKFQIPLDRQSSSQSNHSQPIRKTLPEIPRRCSNSLVKKAMGMDTDGGGKDERMDGLRSEPTLKHFDENIISLIESEIMSVNNQIGWADVAGLEGAKKALKEIVVLPFQRPDIFTGLRAPPKGVLLFGPPGTGKTMIGRCVASQAQATFFNISASSLTSKWVGEGEKLVRALFSVARLKLPSVIFIDEIDSLLSARSESEHESSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARRRFQKRLYIALPEPDSRTQIVENLLRGTRHEITDHNLEKIRRLTDGYSGADMRQLCTEAAMGPIREIGDQIATINKDDIRAVTVADFTEAARVVRPTVDDSQLDAYAAWDKKFGCLPPPL
What is the function of this protein?
Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis.  Required for fertility (By similarity).
What are the official names of this protein?
Fidgetin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRH_STRS2
Sequence: MMKPKYERILIKLSGEALAGERGVGIDLKTVQEMAKEIQEVAESGIQIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLKQLGVDTRVQTAIAMQSVAEPYIRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDANAVKFNELTHREVISRGLKIMDATASTLSMDNDIDLVVFNMNEPGNIKRVVFGEPIGTTVSNSSEEK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJJB_YERPE
Sequence: MGVSLLWALLQDMVLAAIPALGFAMVFNVPVRALRYCALLGAIGHGSRMLMIHFGMNIELASLVASIMIGINWSRWLLAHPKVFTVAAVIPMFPGISAYTAMISVVEISHLGYSEALMSTMVTNFLKASFIVGALSIGLSLPGLWLYRKRPGV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTM3C_BUCAI
Sequence: MLTLIKLKIQNFGRFLSNMIMPNISIFIAWGMMNALFMPLGWQPNKTLEQLISPMIFYLLPILIGYTGGSLISGSRGGLIGSITTIGVITSTNIPMLLGAMISGPLGGWTIKYFDKKIENKVKNGFEMLVNNFSLAILGILLAIISFFTIGPFIEWVSYFLGTLIQIILSYNLLPLTSIIIEPAKIFFLNNVINHGIFSPLGIQDALDKNHSIFFLIESNPGPGLGLLIAWFFFGKGELSKSSGGAALIEFFGGIHEIYFPYVLIKPKLIIPLILGGMSGIFILVLLHGGLISTASPGSILSILAMTPKGLYFSNIISVACSFLVSFISSSILLKYDFNTIQKDSNYTVKQGKNSFNSKTSREDFNNFNFSKIKTIIVACDAGMGSSAMGASILRKKIKNANLNHISVLNMAINALPQDADLIITHQNLTNRAKDNAPFSQHISLKNFLNNHFYDNLVKKLVENMVFLYDNHTDSVNKYTQQKKDALFQLNEENIILNQYASNKEEAINIVGKHLVKQGYVKFDYIDSMLEREKMASTWLGESIALPHGTIEAKDSVLKTGIIFCQFPKGVRFGEDVDDIAYLVIGIAAKNNEHIMVVSNITNALDKKDTIQRLSHTTSIKEALSLLTMEKI
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in D-mannitol transport.
What are the official names of this protein?
PTS system mannitol-specific EIICBA component, EIICBA-Mtl, EII-Mtl.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLU_BUCCC
Sequence: MSEMTPRKIVKELNKYIIGQNNAKRAVAIALRNRWRRMQLNSELRNEITPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDLAIKMIRLQIIKKNKKHAKKRAEERILKILIPVPKDNWNEENLKEKPEKTIQIFRKKLQEGKLDNKEIEIQIAATPIGIEIMSPPGMEELTNQLQSLFQNLSGKKKNLRKLKIKDAMKIIIEEEAAKLINLEELKEKAIYSVEQNSIVFIDEIDKICKHHSSASNSDVSREGVQRDLLPLIEGCTVSTKHGSVKTDHILFIASGAFQTSTPSDLIPELQGRLPIRVELNALTVDDFERILTEPNASITTQYKALIKTEGVDIIFTKKGIRKIAEASWKINESMENIGARRLYTVLEKLMEDISFNSNEKFGQKIYIDEKYVNLHLDKLIENEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF5A_METTP
Sequence: MKEQVEIRTLKEGRYIIIDDEPCIIKSIAHSKPGKHGAAKARIDAIGIFDNQKRSIVAPVTTKVYAPIVERKTGQVLSVGETSVQLMDLKDYTTIDVPITEDMKPKLEPGKEVAYLSSMGKVKMDIR
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMBD1_HUMAN
Sequence: MATSGAASAELVIGWCIFGLLLLAILAFCWIYVRKYQSRRESEVVSTITAIFSLAIALITSALLPVDIFLVSYMKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA
What is the function of this protein?
(Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).
What are the official names of this protein?
Lysosomal cobalamin transport escort protein LMBD1, LMBD1, HDAg-L-interacting protein NESI, LMBR1 domain-containing protein 1, Nuclear export signal-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: PRF1_ARATH
Sequence: MSWQSYVDDHLMCDVEGNHLTAAAILGQDGSVWAQSAKFPQLKPQEIDGIKKDFEEPGFLAPTGLFLGGEKYMVIQGEQGAVIRGKKGPGGVTIKKTNQALVFGFYDEPMTGGQCNLVVERLGDYLIESEL
What is the function of this protein?
Binds to actin monomers and regulates the organization of the actin cytoskeleton (PubMed:26574597).  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (PubMed:29861135).  At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate (PubMed:29861135).  Binds ACT1, ACT7 and ACT11 and inhibits actin polymerization (PubMed:26578694).  Coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during axial cell expansion (PubMed:26574597).  Binds G-actin and poly-L-proline in vitro (PubMed:19200149).  Inhibits cell growth of various pathogenic fungal strains (PubMed:30056100).  May play a role as antifungal proteins in the defense system against fungal pathogen attacks (PubMed:30056100).
What are the official names of this protein?
Profilin-1, AtPROF1, AthPRF1.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Note=Probably associated with cytoplasmic actin filaments.
Protein: YCIB_ECO8A
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CECA1_DROSE
Sequence: MNFYNIFVFVALILAITIGQSEAGWLKKIGKKIERVGQHTRDATIQGLGVAQQAANVAATARG
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin-A1.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_LEUMM
Sequence: MAKKKQNTENYLAQNRKARFNYAIAETFEAGISLTGTEIKSVRAGQITIGDGFVTIHNGNALLTNVHISSYVQGNQFNVDPLRTRQLLLHKREIRVLEKATQEQGVTIVPLKVYLKHGFAKVLVGIGRGKKKYDKREDIKKRDQERELSRRFKN
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SLD7_YEAS7
Sequence: MSRKLCTLNFTLSGKQGSLVIRDIQLWSNRPTASKSTSELRGQFIQYVDLAKLPLWVRSTNMNTYRCYSTSATAQAYFKSKLRNANRGIVIELSDKVDQRSQEPAYLIIFRENTELNCFQVDLTMKHEFDGQVTKLKQEIGKTRASVSKEGSIDIIIQQSQQRKIGTKTKVYRNVHINDKRLQFNETLSKLILGGLRLRGISNSITDYQKLYKITFDAAEFTHRDELKRISMGSGEEVSFESLQETVETLLKLFTKS
What is the function of this protein?
Required for the proper function of SLD3 at the initiation of DNA replication.  Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork.  Required for mitochondrial morphology (By similarity).
What are the official names of this protein?
Mitochondrial morphogenesis protein SLD7, Synthetic lethality with DPB11-24 mutation protein 7.
What is the protein family that this protein belongs to?
Belongs to the SLD7 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle pole.
Protein: VPE_CITSI
Sequence: MTRLASGVLITLLVALAGIADGSRDIAGDILKLPSEAYRFFHNGGGGAKVNDDDDSVGTRWAVLLAGSNGFWNYRHQADICHAYQLLRKGGLKDENIIVFMYDDIAFNEENPRPGVIINHPHGDDVYKGVPKDYTGEDVTVEKFFAVVLGNKTALTGGSGKVVDSGPNDHIFIFYSDHGGPGVLGMPTSRYIYADELIDVLKKKHASGNYKSLVFYLEACESGSIFEGLLLEGLNIYATTASNAEESSWGTYCPGEIPGPPPEYSTCLGDLYSIAWMEDSDIHNLRTETLHQQYELVKTRTASYNSYGSHVMQYGDIGLSKNNLFTYLGTNPANDNYTFVDENSLRPASKAVNQRDADLLHFWDKYRKAPEGTPRKAEAQKQFFEAMSHRMHVDHSIKLIGKLLFGIEKGPEILNTVRPAGQPLVDDWGCLKSLVRTFESHCGALSQYGMKHMRSLANICNTGIGKEKMAEASAQACENIPSGPWSSLDKGFSA
What is the function of this protein?
Asparagine-specific endopeptidase that may be involved in processing of proteins targeted to vacuoles that accumulate during ethylene-regulated processes such as flower opening and flavedo degreening.
What are the official names of this protein?
Vacuolar-processing enzyme, VPE.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
Protein: DCYD_ECOLI
Sequence: MPLHNLTRFPRLEFIGAPTPLEYLPRFSDYLGREIFIKRDDVTPMAMGGNKLRKLEFLAADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPNAQLEELATRVEAQGFRPYVIPVGGSNALGALGYVESALEIAQQCEGAVNISSVVVASGSAGTHAGLAVGLEHLMPESELIGVTVSRSVADQLPKVVNLQQAIAKELELTASAEILLWDDYFAPGYGVPNDEGMEAVKLLARLEGILLDPVYTGKAMAGLIDGISQKRFKDEGPILFIHTGGAPALFAYHPHV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.  Can also catalyze the degradation of 3-chloro-D-alanine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: ACCC_NOSS1
Sequence: MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKSYLNIPNIIAAALTRNASAIHPGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTAKETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKATAGGGGRGMRLVRSPDEFVKLFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLLEEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPVTEMVTGVDLLVEQIRIAQGERLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYLPPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATAINRMKRALRECAITGLPTTIGFHQRIMENPQFLQGNVSTSFVQEMNK
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxylase, Acetyl-coenzyme A carboxylase biotin carboxylase subunit A.
Protein: RUVB_FRAT1
Sequence: MIETDRIISANTAQTNDENVIDRAIRPKTLAEYEGQPAVREQMEIFIQAAKARKDALDHTLIFGPPGLGKTTLSNIIANEMGVELKQTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLVGATTRAGLLTSPLRDRFGIIQRLEFYSIDDLSKIVYRSAKLLNLDITTDGAMEIAKRSRGTPRIANRLLRRVRDYAQVKGSGVICFEIADKALSMLKVDPVGFDHMDHRYLLTLMEKFAGGPVGLDTMSAALSEEKGTIEDVIEPYLIQQGYIMRTARGRIATLLAYNHFKLKIPDNLSADQQQTLSI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: FOXA4_XENTR
Sequence: MLNRVKLEIKDPMDWNTMYQESEIYSGIHNMNNGLPSNSFLPTDVSTVPTSMPYMSNGLSGPVTSIQGNLGSLGSMTQGMVGSLAPPASTPAYPMGYCQGESEFQRDPRTYRRNYSHAKPPYSYISLITMAIQQAPNKMMTLNEIYQWIIDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPEKPGKGSYWTLHPESGNMFENGCYLRRQKRFKCERSKSGEREKKVNKPGDENGGSLKETPVGYDDCSSSRSPQAPVNDGGRDSTGSSIHQASGGSPVGLSPTSEQAGTASQLMYPLGLSNDGYLGLVGEDVHLKHDPFSGRHPFSITQLMSSEQDQTYPSKLEMCPTTDHLVHYSNYSSDYHNMASKNGLDMQTSSSTDNGYYANMYSRPILSSL
What is the function of this protein?
Transcriptional repressor involved in embryonic nervous system development.  Plays a role in the induction and patterning of the anterior-posterior neural axis.  Involved in the establishment of floor plate differentiation from neural plate cells during gastrulation.  Binds the anf1 promoter sequence to restrict expression of anf1 to the anterior of the neural plate, thereby patterning the forebrain.  Can bind to the HNF-3-alpha DNA target sequence.  Cooperates with t/bra in a dose-dependent manner to specify dorsal mesoderm formation, including notochord.  May be involved in the dorso-ventral patterning of the mesoderm.  Binds to DNA via the target sequence 5'-[GA]TAAA[TC]A-3', with 5'-GTAAATA-3' being the preferred binding site (By similarity).
What are the official names of this protein?
Forkhead box protein A4, FoxA4.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRF_WIGBR
Sequence: MINEIYENSNSRMKKSIDFFKKNISKIRTNRVSPSLIENIYINCYGTSVPLSKLSNILSEKSNILKINVFDNNIIKKIEQAILSSDLGVNPQIQENYIRIEFPKLTEARRFELIKLINKEAEQNIISIRNIRRDANEKIKKLIKAKTIGKDEDKKFQEVIQNLTNSRIEDTKKILKLKEKEIKKI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.