PharMolix/UniProtQA huggingface dataset:
Protein: CCS1_SYNS3
Sequence: MPALRRLFALLSDLRLAILLLLLIAGASALGTILPQNEAPDLYLERFNADPWLGMINGEQMLQLQLDSIYSSVWFLSLLAWLGLALILCSWRRQWPALLATTRWIDYRQPRQLSKLALAESILCSNGESALDTLSEELQKQGWQVQRNEDRLAARRGVIGKVGPLLVHTGLVLLLIGAAWGALSGNRLERFLAPGRALDLLDPSGNNRLSLTLERFAIERDPAGRTEQFRSTLRLDPPGGPSEQRMISVNHPLRYRGMTVYQADWSLAAITVQIGKSPELQLPLRSFPELGEQIWGLVLPTRPDGSEPVLMSTSSEQGPVQVFDADGSLLGNLRPGGASTEIKGLPLRVANIMPASGLLLKRDPGVPLVYAGFAITLLGGGLSLIATRQLWAVLDPAPFQPSNRKLHIGGLCNRNLAGLAAELPRLISRVDESRD
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsB.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PAL2_CICAR
Sequence: MMELPNGNCNGSSLNVCNGNGNLSNNDSLNWGMAADSMRGSHLDEVKRMVEEYRKAVVPLGGKGLTISQVAAVATQNTGVAVELAEETRYAVKASSDWVVDSMNKGTDSYGVTTGFGATSHRRTKQGGALQNELIRFLNAGIFGNGTESTQTLPHTATRAAMLVRINTLLQGYSGIRFEIMEAIAKFLNHNITPCLPLRGTITASGDLVPLSYVAGLLIGRPNSKSIGPNGQILNAKEAFQLAGIETGFFELQPKEGLALVNGTAVGSGLASLALFETNLLVVLSEILSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSYYVKAAQKVHDIDPLQKPKQDRYALRTSPQWLGPQIEVIRNATKMIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNTRLAIASIGKLMFAQFSELVNDFYNNGLPSNLTGSRNPSLDYGFKGAEIAMASYCSELQYLANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVEILKLMSSTFLVALCQAIDLRHIEENLKSVVKNTVSQVAKRVLTVGVNGELHPSRFCEKDLLNVVEREYVFAYIDDPCSATYPLMQKLRHVLVDHALENGDREGNSSTSIFQKIGAFEQELKTLLPKEVESVRVDVENGNPAVPNRIIECRSYPLYKFVRENLGTSLLTGEKIRSPGEECDKVFAALCDGRFIDPMLDCLKEWNGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase 2.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPJ_MOUSE
Sequence: MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEADDKQAATNVSTSFPAKATHFSNSFSISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVRKEPIASRQDAPGCQEDNNNDLTPHLESEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSAQHAFPGTLLPDDQSQKHRSPGDLTLPPHSYSNPTQENSCASNVLPDEQSNFCRATQDSVLTSKNASDLFYESQYQEAHVKRNDLKEESPAHPSGEGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDERPIKAAVREKQQTFEDYLEEQIQLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAKSKFQKGKESKLASTQSPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLRQKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSKTQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEFLFLERAADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSNCSEIPRYGVAHENESECEAMLLSWGSGSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDDGVANSDSSTESEEQHDITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKECSSDESVIVESLNNKVLEPLRLPSSQAGSKIDFDDERSWTDLEENPYEHGVIHREEAIYGTPQTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRSQIEMLVKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHVSSGVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSSDKGQAALPREPLQQVNFPDLEYKNKEEKEEEIQGEISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVKQVMPDERVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM
What is the function of this protein?
Plays an important role in cell division and centrosome function by participating in centriole duplication.  Inhibits microtubule nucleation from the centrosome.  Involved in the regulation of slow processive growth of centriolar microtubules.  Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles.  Required for centriole elongation and for STIL-mediated centriole amplification.  Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.  May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity).
What are the official names of this protein?
Centromere protein J, CENP-J.
What is the protein family that this protein belongs to?
Belongs to the TCP10 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (By similarity).
Protein: AMPP2_PYRTT
Sequence: MEVLDATGLAERLRWEDNDYWLHLEAETPFDKYPAKQHARRVQAKLGIEDGLIYLPGQPARNNEDSDMPAPFRQRRYFYYMSGCDEPDCHLMYDIRRDVLTLFIPRIKPERVIWNGRGSTPAEALAKYDIDQVHHSQDLTYIIQNWAFKHQHTSIYILHPSSRIPGCDNLMPRIDSHSLQPAISLCRMIKDDHEIKRIRKANDISSQAHREVLANIHKYKNEAQVEGLFMDVCISQQAKQQAYDPIAASGPNAGTLHYDANNEDLAGRQLMCLDAGCEYELYASDITRTFPLSASWPSKEAENIYNLVQRMQETCIERLEPGVRYLDLHIMAHQIAIDGLLRLGILCNGTREEIYKAGTSRAFFPHGLGHHIGLEVHDVGQAELMSVRRGKPVYQQAPSLYPENFHDPVYDSETCHAPTDPQSSHLEEGMVVTVEPGIYFSVYALQHFYLPSPIHSKFINLEVLERYLPVGGVRIEDDLLITANGHENLTTAPKGEAMLDIIRQGNPGTTEILNPSPTPPRRMRSENRTPRLRAPGISKKTLQPLLTPLARAATLPTELRQQDDIDFEPIVGPSLFSGFSRAMTTEEKIQQWKQKRDSVPTAPSRPTKAKNLSPVCGENTANVQHVYMSTVSDLSSLSQSSVGSGSTSMCKNCGILVQTLDRLRQNLSSSTQTSPKPMTVPTFESRQKSHTVEEKHREMVCTDSLLDKVSIGQSNRAIGPEERRRKAQSDHHHHSRLKAATGEVKSRFSTRYTPAGVPPLMPSHDQYSITRRPNPERMQPVADTPIVPPRHLTYMTSTPQQSTENPALADLGLPRASAEIAAIRATKQAGQEKLDTQRTTLDAFQDEGQRLVIRSRHRLIPQTSMPVLMSQNPYHHHSNRSHGREGNNATNKRSMIDSQPAERRTRPERPERPARDYVPGDEFLTR
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase PTT_10145, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: CH102_VIBPA
Sequence: MKIRPLNDKLIVERQEVENKSEGGIVLTSQSVKKSNRGKVIAVGLGKRFENGERAAMEVKVGDQIIFNDGYGVKTEKIDGAEYLILSESDVLAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES 2, 10 kDa chaperonin 2, Chaperonin-10 2, Cpn10 2.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REL1_PANTR
Sequence: SRAVADSWMDEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETIIIMLEFIANLPPELKAALSERQPSLPEPQQYVPALKDSNLSFEEFKKLIRNRQSEAADSNPSELKYLGLDTHSQKKRQPYVALFEKCCLIGCTKRSLANYC
What is the function of this protein?
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.  May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
What are the official names of this protein?
Prorelaxin H1.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GRAS_STAS1
Sequence: MANLKWFFIFLRSRIYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEALKHKSLADTPFQQEMVNYLYGQITNQKALVTHQKQQIQSTEAALTDFVHDIKTPVTAMKLLIEKEQDLSRKHALLYEWSRINDMLDRQLFLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTLNVYTDTKWCRMMIRQVLSNAVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFPNQNEIVAKLSQNI
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity).
What are the official names of this protein?
Sensor histidine kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYT_STRT1
Sequence: MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKLIDTTRVITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGFYYDTDNQAGQISNEDLPRIEEEMKKIVKENFPSIREEVTKDEAREIFKNDPYKLELIEEHSEDDGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLNVAGAYWRGNSDNAMMQRIYGTAWFDKKDLKAYLKRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRELERYIVDKEVAAGYQHVYTPPIASVELYKTSGHWDHYREDMFPPMDMGDGEEFVLRPMNCPHHIEVYKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHTFVAPEQIEEEFKKILQLIIDVYEDFNLTDYRFRLSYRDPADKHKYFDNDEMWENAQRMLKAAVDDMGVEYYEAEGEAAFYGPKLDIQVKTALGKEETLSTIQLDFLLPERFDLHYIGADGEEHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVAKKLRDRGVRAEVDERNEKMQFKIRASQTQKIPYQLIVGDKEMKDGTVNVRRYGQKQTHTETVSEFVENILADIARKSRPDAE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_METHJ
Sequence: MYAVVQVRGTVKTRREIKDTLKMLRLHHINHCVLIPDTPAYVGMIRKVKDFIAYGEVDAKTLEELLVNRGRLVGDIRLTDEYVKENSQYSGISDFAAALAGGQARLTDVPGLKPVLRLHPPRKGYKTTKRTVQQGGSLGYHGENINDLLYKMR
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL27_ANAPZ
Sequence: MATKKSGGSSCNGRDSRGRRLGVKKFGSELVIPGNIIIRQRGTKYHPGKNVGIGRDHTIFSKIAGVVSFRRKAEGRVFVDVLPESVSASLS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PSD2_SCHPO
Sequence: MRPRQRFRRFHPRWSKVNLRGFGGVGALKGVKALNGMNVRVSMRLKWISNRIHRIRRSRRLGRLSISVRPNGSWQVYLLSSLPLRSLSRVWGQFNRAHLPTFLRTPGFKLYAWVFGCNLSELKDPDLTHYRNFQDFFCRELRPETRPVDPVSPVVSPVDGRIVCQGVVDNNRIQHVKGLSYSLEALLGGISSSNPLVVNFEDEITPDLIQKHEQFAEQHSISLNSNNRYRKADASAAVVDEHSDEEALLCAFTDHPHFYLNDSRNSLNYFCPFSAFEDISNSVRSSCGKRLSPSSNFDLNNLGGDDDLRSESSSDFESAPASILEHEPTNWDDWVQEADVTDIDSLPWHNIRPGNKLFYSVIYLAPGDYHRFHSPADWVIESRRHFSGELFSVSPFLARRLHNLFVLNERVALLGRYEHGFMSMIPVGATNVGSIVINCDPTLSTNRLVLRKKSLGTFQEAVYKNASPVLDGMPVSRGEQVGGFQLGSTVVLVFEAPADFEFSTYQGQYVRVGEAL
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity).  Together with psd1 and psd3, responsible for the majority of phosphatidylethanolamine synthesis (PubMed:19286980).  Plays a role in lipid droplet biogenesis at the endoplasmic reticulum membrane (PubMed:34818062).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
[Phosphatidylserine decarboxylase 2 beta chain]: Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Nucleus envelope. SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase 2 alpha chain]: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Nucleus envelope. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.
Protein: FUB4_GIBM7
Sequence: MRFLCLHGYAFSVEVLQQQMEPITAHLPSDWEYEFLEAGMEPTQLMLPNLKQVPKPNSSWYNFPYPEDVEEAYERLAAYVESEGPFDGIWGFSQGGSMAALLLLMHQAEHPDTPYPFKMAIFTSAFLPHSFDNGVISWDLTEKNTLEPAYLPGRIDVSHGKKLDWKKDLHTSIEYDMINAVKDELDFPVDLLLRWRPSDIPEKIPVPSVHVRGLKDHYSFVDESVYELFDPDMARKMTHRGGHNFPRYNEELVHFAELIIETVVSLH
What is the function of this protein?
Hydrolase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:22652150, PubMed:25372119).  L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity).  The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity).  FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity).  Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity).  Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
What are the official names of this protein?
Hydrolase FUB4, Fusaric acid biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase 3 family.
Protein: GLIA_ASPFU
Sequence: MSRPSIEESKQELSSSPNDSVMGKDPAPEEEMQYPSGFALSVIMAGLLAAIFLISLDTTIVSTAIPRITDEFHTVADIGWYGSAFFLTLASFQGTWGKIYRYFPLKLSFLAAVLLFEVGSLICAVAKNSVTLIVGRAIAGIGAAGISSGSYTILAFSVHPRRRAAMTGAIGASFAVAAVAGPLIGGAFTSHTTWRWCFWINLPIGGVSAGLIAIFFKAPPQARAKDVPYKEILLQMDPSGIVLLLGAILCFLLALQWGGSAKAWGNADVVGTLVGFGLLLIAFAINELWLQEKAMIPPRLFKGQTILFSSLFTFFFSGSFYLLLYYLPTYFQSVKGASASDSGVRTLPLVLGDGLFATLSGAVLGIIGYYMPLLTLGGVLTTVASGLLYTLDLDSGANAWIGYQAMAGIGIGLAIQVPMMASQAVVRVEDLSTVSAIVLFFQCMGGAIFVQAGQAAFTNKLVQEVQRHLPNISAARVTSTGATELQSEFHGHELQVILEAYVAGLKDAFIVAIVLAGIATLLSFGSGWRSVKSKKEEPKAQP
What is the function of this protein?
Efflux pump that provides the dual role of gliotoxin export and self-protection by allowing the fungus to evade the harmful effect of its own gliotoxin production (PubMed:15979823, PubMed:15707846, PubMed:24847038, PubMed:26150413).  Moreover, it contributes also to the virulence through gliotoxin secretion (PubMed:24847038).
What are the official names of this protein?
MFS gliotoxin efflux transporter gliA, Gliotoxin biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AXE2_TALPU
Sequence: MHSKFFAASLLGLGAAAIPLEGVMEKRSCPAIHVFGARETTASPGYGSSSTVVNGVLSAYPGSTAEAINYPACGGQSSCGGASYSSSVAQGIAAVASAVNSFNSQCPSTKIVLVGYSQGGEIMDVALCGGGDPNQGYTNTAVQLSSSAVNMVKAAIFMGDPMFRAGLSYEVGTCAAGGFDQRPAGFSCPSAAKIKSYCDASDPYCCNGSNAATHQGYGSEYGSQALAFVKSKLG
What is the function of this protein?
Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.
What are the official names of this protein?
Acetylxylan esterase 2, AXE II.
What is the protein family that this protein belongs to?
Belongs to the cutinase family. Acetylxylan esterase subfamily.
Protein: RS16_HALHL
Sequence: MVTIRLARAGAKKRPFYHIVVTEAKKPRDGAFIERLGYFNPVASGQEAPLKLDVERSKAWIAKGAQPTERAAQLIRQAERAEQAAQ
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL34_BACLD
Sequence: MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: METK_SULNB
Sequence: MANEYIFTSESVTEGHPDKMADQISDAILDYIIERDPQARVACETLLSNGFCVIAGELKTAAYAPMQEIAREVVREIGYTDAAYGFDYRSAGVLNGIGEQSPDINVGVDQKGGEIGAGDQGLMFGYACKETKELMPLPISLAHHITRKLAAVRKNGTVPFLRPDGKAQVSVKYVDGKPVAVDTIVVSTQHHETVSLEQVQKAVKEEVIDPVLATYDIDISDITYHINPTGRFVIGGPQGDAGLTGRKIIVDTYGGSCPHGGGAFSGKDPTKVDRSAAYAARYVAKNLVAAGACDKATLQVAYAIGVAKPVSIYVDTHGTAHIDEEKIVSCVESLFDLTPKGIIDSLDLLKPIYKKTAAYGHFGREDMGFSWEKIDKVDEIKAFLGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_STAA3
Sequence: MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_HAEIN
Sequence: MISLESQVLERHISFFDGKSVLFAGGISDSFPQTLASKCSSIQIWSCYFDYARTQSAVNFSVEFQGQADLIVYYWTKNKQEVNFQLIQLLAQASIGQEILIIGENRCGVRSVEKTLSPYGEIAKIDSARRCGLYHFSLQNKPHFELKNFWRTYQHSTLENLTIYSLPGVFSAAELDTGTELLLSTIDNKIKGKVLDLGCGAGVIGSMIKKRTPNAQITMTDIHAMALESARKTLSENQLQGEVYASDVFSDIEGKFDLIISNPPFHDGIDTAYRAVTELITQAKWHLNQGGELRIVANSFLPYPELLRQHFNDYQVLAQTGKFKVYSVKN
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_MYCBP
Sequence: MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINVVTSAATDDEGRALLRALGFPFKEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: 3HAO_CUPPJ
Sequence: MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEELFYQFKGNAYLLLWEDGRYERVDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQNDAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSEDARRCPGCGEIHPGRDFQAWHRTLARHSS
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
Protein: MFS11_XENLA
Sequence: MSPESRKLLNIVILGVGFMFMFTAFQTSGNVAQTVISSLNSTSFHGSGYTSLAIIYSVFSASNLIAPSVIAVLGCQMSMFLSGLLYSAYIAMFIQPYTWSFYTLSVLIGIAAAVLWTAQGCCLTINSDERTIGRHSGIFWALLQFSMLFGNLYIYLAWKGEINISDTDRRTVFIALTVISLVGSVLFFLIRTPDSDSAQEDEASDSVADAEGSMSAQGCLSKAMDAFRKSLKLSITKEMLLLSILVAYTGLELTFYSGVYGTCIGSMNVFGTDAKSLIGLSGIFVGLGEVLGGGLFGLLGKNNYFGRNPVVILGVVVHFLAFYMIYLYMPSDAPIASRSGTDLSAFINPSKTLALACSFLLGLGDSCYNTQMLSILGSLYPDNSAPAFAVFKFVQSVSAAVAFFYSNYLLLHWQLLILVIFGFFGTISFFFVEWGLTQRSLYNSM
What are the official names of this protein?
UNC93-like protein MFSD11, Major facilitator superfamily domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the unc-93 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YLU1_CAEEL
Sequence: MTFEILELLDKTAVRKPLQKQLNFSLRFHQICYAWISVSTIWYIFFSAWFIRAAGYIFSGITVSIAFLLSIAFFCEADGKGWKKFVTLCIICAAPRLFFTPIYAVANIQTSHANNTMEFIEEFHNLGIMGFKDNKYNDISIIWFVYYYNFMLVFLAIQRLFCRKAVEEKKMKIFADTLREEQQKRTENEEAVGPLHI
What are the official names of this protein?
Uncharacterized protein F10E9.1.
Protein: X_HBVF1
Sequence: MAARMCCKLDPARDVLCLRPIGAESRGRPLPGPLGAVPPSSPSAVPADDGSHLSLRGLPVCSFSSAGPCALRFTSARRMETTVNAPWSLPTVLHKRTLGLSGWSMTWIEEYIKDCVFKDWEELGEEIRLKVFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: RL19_SOLM1
Sequence: MNVIDQLEREQMRMDIPAFRPGDTIKVHLRIIEGEKERIQVFQGAVLRLRKGGVDSTFTVRKVSDGVGVERVFPMHSPFIERIEVVAQGKVRRSRLYYLRALRGKAARIKTRTAWD
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.