PharMolix/UniProtQA huggingface dataset:
Protein: AROC_METSB
Sequence: MSHNSFGHLFRVTTFGESHGPAIGCVVDGCPPGLPLVEDDIQIFLDRRRPGQNRFMTQRQEADKVKILSGVFEDAQTGGQVTTGTPIALLIENTDQRSKDYEAIKDVYRPGHADYVYDAKYGVRDYRGGGRSSARETASRVAAGAVARKIIASVKIRGALVQMGPHKIDRAHWDWEEVDKNPFFCPDAAAARFFETYLDGVRKAGSSIGAVIEIVAENAPAGWGAPIYGKLDSEIAAALMSINAVKGVEIGEGFAAAELSGEDNADEMRSGNEGKPIFLSNHAGGVLGGISTGQPIVARFAVKPTSSILKPRQSIDRFGRESEIVTKGRHDPCVGIRAVPVGEAMVACVLADQFLRHRGQVGSGPAWPFPA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: IOLG_BACSU
Sequence: MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKVVEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATTAEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTVGDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETKGGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRFVAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPEFYQSFTTVQN
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.  Can also use D-glucose and D-xylose, and shows a trace of activity with D-ribose and D-fructose.
What are the official names of this protein?
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, MI 2-dehydrogenase/DCI 3-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: KANL1_HUMAN
Sequence: MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGKRALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPLSSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASETTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR
What is the function of this protein?
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
What are the official names of this protein?
KAT8 regulatory NSL complex subunit 1, MLL1/MLL complex subunit KANSL1, MSL1 homolog 1, hMSL1v1, NSL complex protein NSL1, Non-specific lethal 1 homolog.
What are the subcellular locations of this protein?
Nucleus. Nucleus. Chromosome, centromere, kinetochore.
Protein: EFCB_PAPAN
Sequence: MISAVLNLPSTPLLPLLWFTLIIPASLTNPKFVWRFSITETWSTGNQAHSQTQGTADCSPQGCQDALLLNFHLSSVGNYDHPVICFLYDQTEYNCKNYWQETNLGCPYNYCNMHEIGLMCANGICTPNDRPFVRNRTSGGYILTIKDPWDPRWAQGVKGGLYATSWSSYPTATLQIKRVYVQQVPAPKSKQVDPPKSVQALQNLTSVVKSHEQKIQKLLSPPNSPNNEDPFSWLTLIRQGLNLTQAAGVRNLSHCFLCAALGKAPLVAVPLPTAFNITTDSTSSSQATSLPQVPLYRNPQSQTLPFCYSTPNSSWCDRTQAPSRTQTAPVGGYFWCNQTLSKTLNHASITQSLCVPVSLVPSLTLYSEGELAELASQLSSSNNIQKQAVFLPLIIGVSLASSLVASGLGTGALTHSIQSTQTLSTQVQAAIEASAESLASLQRQITSVAQVAAQNRRALDLLTAEKGGTCLFLGEECCYYVNESGLVDTNVKTLNKIKKELQQFNAPLTPGPPVWLLPVVQQMLPFLIPILILCLMLCLAPILIKFLRARVQEITRVTFNQMLLHPYTQLPTSDPNYAP
What is the function of this protein?
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
ERV-BabFcenv provirus ancestral Env polyprotein, BabFcenv, Envelope polyprotein.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I F(c)1 env subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=At the origin, this retroviral envelope protein was localized in the virion.
Protein: GRM7_PONAB
Sequence: MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPGLSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTRISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTIGGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPPSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNNCIPPVRKSVQKSVTWYTIPPTV
What is the function of this protein?
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity).
What are the official names of this protein?
Metabotropic glutamate receptor 7, mGluR7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IF2_NOCSJ
Sequence: MAKTRVHELAKEFGVESKFVLEKFKEMGEFVKSASSTVELPAEMRFRKEYGEKLKAEASAAPAAPAEKPAAKKAPAKKAAATAEPEALAAEPAAEPAAAEAPAAAEAEAPAAKAAAPKPGPKPAPVAEQPAPPAEPEAPEAPEAPAASAAPAAPKAPAPRPVGRPGAPRPGNNPFASSQGMGRRPAPGAPAAPGAGDNRPPRPPAAREGGVPGRPGMPRPNPAMMPKSPSAFGAGPGGRGPARPGAPGRGGAPGRGGAPGRGGVGTGAPGRGGAPGGGFGPSGGGRPGGGRPGQRGQTQGAFGRPGGPSRRGRKSKRARRQEFEAMEAPTIGGIRVRKGNGETVRLPRGASLTDFAERINVEPAQLVQMLFSLGEMVTATESVNDETLELLGEELNYVVEVVSPEDEDRELLESFDIEFADDEDDEGHFEARPPVVTVMGHVDHGKTKLLDALRHANVASGEAGGITQHIGAYQVHTDVDGEDRKITFIDTPGHEAFTAMRARGSQSSDIAVLVVAADDGVMPQTVEALNHAKAAGVPIVVAVNKIDKPEADPTKVRGQLTEYGLVPEEYGGDTMFVDVSAKSELNLDKLLEAVVLTADASLDLRANPNRDAQGLVIEAHLDRGRGPVATILVQRGTLHVGDSIVAGPAHGRVRAMLDEYGNELTEATPSRPAMVLGLSTVPGAGQNFIVVEDDRMARQIAEKREARERAAMQAKRRVRRTLEDFMASMEKGESQELNLILKGDVSGSVEALEDALAKIDVGDDVSLRVIDRGVGAITETNVDLAAASDAIIIGFNVRPQGKATELADREGVEIRYYTVIYQAIEEIEAALKGMLKPEFEESTLGQAEIRAIFRSSKVGNIAGCMVISGVIRRNAKVRVIRDGAVVADNLDLASLKREKDDASEVREGFECGLVLRNFQDIKEGDIVEAFEMREIPRA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_BACC4
Sequence: MSKEIAKKRIEELRDLLNTFNYQYHVLDNPSVSDAEYDRNMQELIKLEAENPEFMSEDSPSVRVGGTVLDIFEKVTHKSPMLSLGNAFNEGDLRDFDRRVRQGIDGANVRYICELKIDGLAVSLHYEKGRFIQGATRGDGVTGEDITQNLKTIKAIPLRLNEEVTLEARGEAYMPKRSFVKLNEEKEQNGEDVFANPRNAAAGSIRQLDPKIAAKRNLSMFVYGLANVEEKTIPSHSESLDFLGELGFKTNPNRRTCETIEEVIAYVEEWQEKRPHLDYEIDGIVIKVDDVALQESLGTTAKSPRWAIAYKFPAEEVVTRLTGIELSVGRTGVVTPTAELEPVRVAGTIVRRASLHNEDLIREKDIRIGDYVVVKKAGDIIPEVVNVIFDKRTGEEEEYRMPTHCPACESELVRLEEEVALRCINPTCPAQIREGLIHFVSRNAMNIDGLGERVITQLFDADYIRTFADLYALTKEQLLQLERFGEKSATNLIQAIENSKENSLERLLFGLGIRHVGAKAARTFAEHFETMDELVKATEEELKAINEIGEKMAQSVVTYFDNEDVLELLQQFKEYGVNMKYKGIKIADLQNVESYFAGKTVVLTGKLEVMGRSEAKKKIEALGGKVTGSVSKSTDLVVAGEAAGSKLAQAEKHNVEVWNEERFLQELNK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DEOC_MYCBP
Sequence: MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVCVSPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAALCGDIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKTSTGCHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRAVLDGLS
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_THESQ
Sequence: MKIGVLGVQGDVREHVEALHKLGVETLIVKLPEQLDMVDGLILPGGESTTMIRILKEMDMDEKLVERINNGLPVFATCAGVILLAKRIENYSQEKLGVLDITVERNAYGRQVESFETFVEIPAVGKDPFRAIFIRAPRIVETGKNVEILATYDYDPVLVKEGNILACTFHPELTDDLRLHRYFLEMVK
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RS12_MYCMM
Sequence: MPTIQQLVRKGRRDKIGKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: TUSD_PROMH
Sequence: MNLTYCLLVTGPHYGTEQASSAYLFAKALLEKGHHIAQVFFYREGVSNANQLVSPASDEFDLPKAWIALASRYNIPLQVCVAAALRRGVVDEQQAKEQGLLSSNMATKFELSGLGALAQAMLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADE_BACSU
Sequence: MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
What is the function of this protein?
Involved in the degradation of long-chain fatty acids.
What are the official names of this protein?
Probable acyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: EFM3_CHATD
Sequence: MVASRNPQTARFCWQYLQLEQSLDFPDGELLRDEAVQETIYQQLFAPNAPTPLPPARYRLRVLKELTSRIESAIEDWETHGISDNLMDAMAELVAQPLPSEAEAAQERCYVTYYLSLLEGGLEKPHITLLESRSLISASGTTGLRTWEAALHLGQFLSVNSGLVKDKRVLELGTGTGYLAVLCAKYLGTSHVIASDGSEEVVEKLSDNLFVNGLQDSDKVQPMELKWGHALLGTEEEHWNGGRKIDVVLGADITYDVSVIPALIATLEELVDLYPGISIIIAATERNRETYETFLAACGRRGFSVTPESFPVPSRAEQKGPFYKDGTPIHICQLRR
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 2.
What are the official names of this protein?
Protein-lysine N-methyltransferase EFM3, Elongation factor methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAT3_ARATH
Sequence: MNNNHSYDDRSFHIPLHPSNTSNPNPNLQFALSSSYDHSPKKKRTKTVASSSSSSPKSASKPKYTKKPDPNAPKITRPCTECGRKFWSWKALFGHMRCHPERQWRGINPPPNYRVPTAASSKQLNQILPNWVSFMSEEDHEVASCLLMLSNGTPSSSSIERFECGGCKKVFGSHQALGGHRASHKNVKGCFAITNVTDDPMTVSTSSGHDHQGKILTFSGHHKCNICFRVFSSGQALGGHMRCHWEKEEEPMISGALDLNVPPTIQDLSTSDTSGCCLDLRLGL
What is the function of this protein?
Mediates the regulation of male germ cell division by DUO1.
What are the official names of this protein?
Zinc finger protein ZAT3, Protein DUO1-ACTIVATED ZINC FINGER 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTU_KINRD
Sequence: MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITRVLHDKFPELNKASAFDQIDKAPEERQRGITISIAHVEYQTEARHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVILARQVGVPYIVVALNKADMVEDEELLELVEMEVRELLSSYEFPGDDVPVVRVSALKALEGDAEWGDKLMELMDAVDTAIPEPERAIDQPFLMPIEDVFTITGRGTVVTGRIERGVLNVNQEVEVVGIKPTSTKTTVTSIEMFNKMLDTGQAGDNAALLLRGLKRDDVERGQVVVKPGSITPHTEFEGQAYILSKDEGGRHTPFYNNYRPQFYFRTTDVTGVVSLPEGTEMVMPGDNTEMKVDLIQPIAMEEGLKFAIREGGRTVGAGRVVKILK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BABA2_MOUSE
Sequence: MSPEIALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALHNLASWNPSNPECLLLVVKELVQQYHQFQCGRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins (By similarity).  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.  May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:9737713).
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: GHRB_ESCF3
Sequence: MKPSIILYKKLPDVLLQRLEEHFTVTQVSNLSPQTVEQHAEAFANAEGLLGSSEKVDDALLEKMPKLRATSTISVGYDNFDVDALNARKVLLMHTPTVLTETVADTLMALILATSRRVVEVAERVKAGEWTASIGPDWFGSDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRQHPQAEERFNARYCDLDTLLQEADFVCLILPLTEETHHLFGAEQFAKMKSSAIFINAGRGPVVDEKALISALQKGEIHAAGLDVFEREPLPVDSPLLAMPNVVALPHIGSATHETRYNMAACAVDNLIAALQGNVDKNCVNPQVAK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_PROMA
Sequence: MDTSTLKARLETASATFNNLELQLADPDVASDPKKLETIARERARLEPLVLDYKELQAIDLEYKEAKELLRQSKSDKEMEALAQEELIRLEELEKDLVNRLTLALLPKDPRDERSVMLEIRAGAGGDEACIWAGDLARMYERYGLKVGWVVKAMSATEADLGGFRELIISVKGKAVFSQLKFEAGVHRVQRVPATESQGRVHTSTATVAVMPEADPVEVKLEPTDLEISTARSGGAGGQNVNKVETAVDLLHKPTGIRVFCTQERSQLQNRERALEILRAKLLEREIEEANAKERSARLAQVGTGDRSEKIRTYNYKDNRTTDHRLGVNFPLETVLEGELDDLIGACIAEEQRLKMEKLGNQSEE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_BORAP
Sequence: MILKLHNTRTKDFSELTNFDNVKVYACGPTVYNYAHIGNFRTYIFGDLLIKTLRFLGYKVNYAMNITDIGHLTGDLDDGEDKVVKTAREKGLTVQEISEFFTEAFFKDCRKLNVVYPDKVLIASKHIPIMIEVVKILEEKKITYFSNGNVYFDTSCFKSYGEMAGIDLIDKDMTFSRVDIDKFKRNKTDFVLWFTNSKFKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKDTLDIHLGGVDHIGVHHINEIAIVECFLNKKWCDIFVHGEFLIMDYNKMSKSRGNFITVKDLEEQNFSPLDFRYLCLTSHYRNQLKFSLNNLQASKIARENMINRLSYFYASLDPVALGVLNKDLKNFGFSEEKEYYDSFIEKVSFDLNISQGLALLWEIIKSENLSFVSKLRLAFIFDEIMSLNLREEILKNLENHDVVVDENMKTLIEERRIAKCEKNFKRADEIRDFFAKKGFVLVDTKEGTKVKRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_STRM5
Sequence: MRTHFCGLVDETLIGQTVTLAGWTDVARNQGGVCFIDLRDHEGIVQVTVEVDNAEVFAVAASLGYEDVLQVEGVVRARHAVNDKMRTGKVEVIATAITVLNKAAPLPFHAHENPGEETRLKYRYLDLRRPEMQRMQRTRIKLVQALRRHLDEKGFQDIETPILTKATPEGARDFLVPARMHPGEFYALPQSPQLFKQILMVAGFDRYYQIARCFRDEALRADRQLEFTQLDMEFAFVRERDVQDFVEDMIRGIFKEVVNVELDASFPRMTWAEAMRRYGSDKPDLRIALELVDVAELVKNSEFPVFTGPANDADGRVAALRIPGGASLSRKQIDEYAAHAAKYGAKGLAYIKIADNGEVSSPIQKFFSEESFAALVAHVGAGNGDIVFFGAGGYNKVSDFMGALRLKAGKDFGLVADGWAPLWVTDFPMFEWDEEEQRYVALHHPFTAPAVDDIADLRANARTAVSRGYDMVLNGNEIGGGSIRIHRPDMQSAVFELLGIGAEEARAKFGFLLDALNYGAPPHGGIAFGIDRIAALMAGTESIRDVIPFPKTTGAQDLMTDAPSPIVDAQLAEVHIQVRPKTN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_SYNSC
Sequence: MMPDHGELLYEGKAKRVFASTDPDRVLVEFKNDATAFNAQKKAQLDGKGRLNCQISARLFDLLEREGVPTHYCGLAGETWMLVRRVRIIPLEVVLRNIATGSLCRQTPIAEGTAIEPALLDLYYKDDSLGDPLLTEARVQLLGVADTAQLSAIEQLARRVNAVLLPFFDELDLQLVDFKLELGLASDGTLLLADEISPDTCRLWDRRNSNAEDRILDKDRFRKDLGGVMEAYGEVLKRVQGNCPNPRNCL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: YZ10_AQUAE
Sequence: MNKLLESPYDIVLEEVREGKVNPFDVDLDHLIALFRKKAKELKGSEYMLEAGKFLEASSKLLLLKLEYFFPKSQKERKKVSLKEVQEVLIEEGEEDLSRFDTSFLWEYSPEVGRPKSSKGEKPKILEWREFWKLSKERVPLHREPNWQEEAKRVYEEIKRGVFRIRNLRDFIAFLFAYMEYEEVQKEELLRRLL
What are the official names of this protein?
Uncharacterized protein aq_aa10.
What is the protein family that this protein belongs to?
To A.aeolicus AQ_423.
Protein: ISPF_CUPNH
Sequence: MMPFDIRVGQGYDVHALVPGRKLILGGVEIPHDRGLLGHSDADALLHAVTDALFGAAALGDIGRHFPDTDAQFAGADSRVLLREAARRVREAGYEIGNVDATVIAQAPKLAPHIGAMVANLAEDLGIARGRCNVKAKTNEKLGFEGRQEGIVAQAAVLLWRASVGDAQD
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: SYFA_CLOBJ
Sequence: MRQKLEEIKNSAINELKTTLSKDQLEAIRVKYLGKKGELTQILRGMGALSQEERPIVGKVANEVRSYIEETIKEAFSDIKNKEKSIRLENETIDITMPGKKQAVGKRHPLDLTLESMKDIFISMGFTIEEGPEVELDKYNFEALNIPKNHPARGEQDTFYINDNLVLRTQTSPIQIRTMENQKPPIKMIAPGKVYRSDSVDATHSPIFYQMEGLVVDKGITFSDLKGTLELFAKRMFGDKVKTKFRPHHFPFTEPSAEMDATCFVCNGEGCKVCKGSGWIELLGCGMVHPQVLRNCNIDPEVYSGFAFGFGVDRMVMMKYGIDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.