PharMolix/UniProtQA huggingface dataset:
Protein: SSU1_TRIRU
Sequence: MPSGSGFHNIEEAGEKARKRDDWIAISNFHPGWFSVNMGTGITAILLQNLPYQFPGLHYIAVVLFILNVIIFFLFLTISITRYCLWPDKFKAMLAHPAHSMLLGTFPMGFATIINCIVFICVPVWGEWASRFAWGLWWIDAAVSVAICYFVPFMLMTKHTSSLETMTAAWLLPIVAPVVAAASGGVVADSLQNDTHALITILVCYAMWGSAVPLAMVILVIYFQRLAIHKLVPRAAIVSALLPIGPLGQGGFGLMQLGVVAKRVFPRLDFLAPIAGDIFYVMGAFIAMIMWGFGLIWLWFALASFTRGKFYFNIGWWAFTFPLGVFTTATTQMGKEFNSPFFDILGTFFSIVVTCMWVLVFALTVYKSCTKELFR
What is the function of this protein?
Sulphite efflux pump required for the secretion of sulphite as a reducing agent.  In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases.  Excretion of sulphite mediated by an efflux pump represents also an detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.
What are the official names of this protein?
Sulfite efflux pump SSU1.
What is the protein family that this protein belongs to?
Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSN2_PONAB
Sequence: MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYICSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVAMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the other members of the gamma-secretase complex to have a protease activity.  May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.  May function in the cytoplasmic partitioning of proteins.  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis.  Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
What are the official names of this protein?
Presenilin-2, PS-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RUTA_PSEU2
Sequence: MDIGIFIPIGNNGWLISSNAPQYMPTFELNKQIVQKAEGYGFDFALSMIKLRGFGGKTQFWEHNLESFTLMAGLAAVTSRIQLFATVATLTIPPAIAARMASTIDSISNGRFGINLVTGWQKPEYEQMGLWPGDEFFHTRYEYLAEYAQVLRDLWATGSSDFKGEHFSMQDCRVSPRPQADMKLICAGQSEAGMAFSAQYADYNFCFGKGVNTPTAFAPTAQKLLEANEKTGRNVTSCVLFMIIADDTDEAARARWEHIKDGADEEAIAWLSEKGSADKSAGSNLRQMADPTSAVNINMGTLVGSWATVARMLDEVASVPGTQGVMLTFDDFVKGVEDFGEKIQPLMTSRKHIAQLKEVV
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: SYE_ACIAC
Sequence: MSQSLSSASSSGAPQRVRTRFAPSPTGFIHLGNIRSALYPWAFARATGGDFILRIEDTDVERSSQAAVDVILEGMQWLGMEPDEGPFYQMQRMDRYKEVLAQMQAQGLVYPCYMSVAELDALRERQMQAKQKPRYDGTWRPEEGKTLPPVPEGVQPVLRFRNPVGGSVVWEDKVKGRIEIQNDELDDLVIARPDGTPTYNFCVVVDDIDMAITHVIRGDDHVNNTPRQINIFRALGKEPPVYAHLPTVLNEQGEKMSKRNGAKPVTQYRDEGYLPEAMVNYLARLGWSHGDDEIFSREQFLEWFDLDHLGRSAAQFDEAKLRWVNAQHLKATADERLAELVAPRLAARGIAQSELADGRLPRICALFKDRCDTLVALADWAHVFYGEVTPNEEERAKHVVDAVKPAIAALSDALAQCAWDKASIAAAFKEVLAAQGLKMPQLAMPVRVLTVGTAHTPSVDAVLELLGREKIAARLRTA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_STRGG
Sequence: MSVLDEIIDGVRADLAERQARVSLDELKERAARAPQAKDGVAALRGEGVTVICEVKRSSPSKGALAAIADPAALAADYEAGGASVISVLTEERRFGGSLADLEAVRAKVDIPILRKDFIVTSYQLWEARAYGADLALLIVAALDQEALVSLIERAESIGLTPLVEAHDEEEAERAVDAGAKIIGVNARNLKDLKVDRSTFERVAPEIPDHIVKVAESGVRGPHDLIAYANAGADAVLVGESLVTGRDPRAAVADLVAAGAHPALRHGRG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: G2OX2_ORYSJ
Sequence: MVVPAAAAPECGRREAAAAAAAAVFCRRGRGVVVPTVDMSAPAGRGELSRQVARACAGSGFFRAVNHGVPPRVSAAMDAAAAAFFVRAGAEKQLAGPPDPLGYGSRSIGANGDVGELEYLILHASPDAVARKASAIDREDPRRFSQVVNDYVEAVRQLACHVLDLLGEGLGLRDPTSLTRLITATDNDSLIRINHYPPSCAAAAGDHKSGGGPAPTAAIGFGEHTDPQILSVLRANDADGLQLLLPDAAAAGDSVWVPVPPDPSAFFVNVGDLLQALTNGRLVSIRHRVVVGTGKPRLSTIYFAAPPLHARISALPETVAAGAPRRYRAFTWAEYKRTMYTLRLSHNRLDLFHAGDGDGDAGVGDDDDHE
What is the function of this protein?
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level.  Catabolism of gibberellins (GAs) plays a central role in plant development.
What are the official names of this protein?
Gibberellin 2-beta-dioxygenase 2, Gibberellin 2-beta-hydroxylase 2, Gibberellin 2-oxidase 2, GA 2-oxidase 2, OsGA2ox2.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily.
Protein: GLNK1_METJA
Sequence: MKKVEAIIRPEKLEIVKKALSDAGYVGMTVSEVKGRGVQGGIVERYRGREYIVDLIPKVKIELVVKEEDVDNVIDIICENARTGNPGDGKIFVIPVERVVRVRTKEEGKEAL
What is the function of this protein?
Involved in the regulation of nitrogen metabolism (PubMed:17203075).  Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell (PubMed:17203075).  Regulates the activity of the ammonia channel Amt1 via direct interaction (PubMed:17203075).
What are the official names of this protein?
Nitrogen regulatory protein GlnK1.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_SHESA
Sequence: MPLLDSFTVDHTRMNAPAVRVAKHMSTPKGDAITVFDLRFCAPNKDILSERGIHTLEHLFAGFMRDHLNGSDVEIIDISPMGCRTGFYMSLIGEPSERQVADAWLASMEDVLKVVEQSEIPELNEYQCGTYEMHSLEQAQDIARNIIAAGVSVNRNDDLKLSDEILGQL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RPOA_BROIN
Sequence: MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGEIEGTCIARAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPIDFCIDLQIKRDRGYQTELRKNYQDGSYPIDAVSMPVRNVNYSIFSCGNGNEKHEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHAEEEGTSFEENKNRFTPPLFTFKKRLTNLKKNKKGIPLNCIFIDQLELTSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMEDRKHIWDTLEKHLPIDLLKNKLSF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y3851_SHEB9
Sequence: MEQIFEKLMYASRWIMAPIYLGLSLVLIGLGIKFFQEIFHILPIIFEITEVDLVLVTLSLIDITLVGGLIVMVMFSGYENFVSQLDVGEDSEKLSWLGKLDSGSLKNKVAASIVAISSIHLLKIFMDVKNIDNDKIMWYLLIHITFVLSAFAMGYLDKMTRAGK
What are the official names of this protein?
UPF0114 protein Sbal195_3851.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CUO5_BLACR
Sequence: GGYYGYPYGVVGAVHDTPEVAAAKAAHFAAVAAAGGAAAVPLYGGAYVGAHDDGQYHPGLYGDEGQYHSHYDGGYVGYAGGYDDGQYRPGLYGDEGQYHGEGYAGHYAGPIAGVPVIVNGVPADTPAVAAAKAAHFAAHAHAAHY
What are the official names of this protein?
Cuticle protein 5, BcNCP14.6.
Protein: HTRA1_HUMAN
Sequence: MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
What is the function of this protein?
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin.  HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production.  May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.  Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space.  Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.  Inhibits signaling mediated by TGF-beta family members.  This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded.  By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development.  Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
What are the official names of this protein?
Serine protease HTRA1, High-temperature requirement A serine peptidase 1, L56, Serine protease 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane. Secreted. Cytoplasm, cytosol. Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635).
Protein: CDOA_BACSU
Sequence: MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPDQYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEHAELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLENS
What are the official names of this protein?
Cysteine dioxygenase, CDO.
What is the protein family that this protein belongs to?
Belongs to the cysteine dioxygenase family.
Protein: ENO_LACP7
Sequence: MKKLLSIEKVKGREILDSRGNPTVEAEVILSDGSVGMAAAPSGASTGAFEAVELRDGDKGRYLGNGVLNAVEHVKKELSEAVCGRNPLNQVEIDAAMIDADGTENKGKLGANAILAVSLATAKAAATAVSLPLYQYLGGTNARTLPVPMMNIINGGKHADSSLNIQEFMIMPVGAKSFSEALEHSTTVFHTLKKLLKADGYVTAVGDEGGFAPKFNSDEQALEYIVEAIKKAGFEPGSDFYIAMDAAATEMYDEAKKIGKEGNYLFWKSGELKTVDEMIDYWENLCNKYPILSLEDGLAEEDWEGWKKLTERLGSRIQLVGDDLFVTNTNRISKGIKEDISNSVLIKFNQIGSLTETLNAIEMTKNQGWTAIVSHRSGETEDTTIADIAVATNAGQIKTGAPSRSDRVAKYNQLLRIEQELGQAAIYPGKKAFKVLK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL333_BACP2
Sequence: MRVKITLACTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ITK_MOUSE
Sequence: MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIAEAGL
What is the function of this protein?
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response.  Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.  When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK.  Phosphorylation leads to ITK autophosphorylation and full activation.  Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates.  In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty.  Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2.  Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.  Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (PubMed:23562159).  Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016).
What are the official names of this protein?
Tyrosine-protein kinase ITK/TSK, IL-2-inducible T-cell kinase, Kinase EMT, Kinase TLK, T-cell-specific kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Protein: ISPG_BACSU
Sequence: MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEATVAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGADKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTVKSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGKIVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: GLYC_TACVT
Sequence: MGQFISFMQEIPIFLQEALNIALVAVSLICIVKGLVNLYRCGLFQLMVFLVLAGRSCSEETFKIGMHTQFQEVSLSLSALLTNQSHELPMLCLANKTHLYLKSGRSSFKINIDSVTVLTRSADVFVHSPKLGSCFESDEEWVVAWWIEAIGHRWDQDPGLLCRNKTKTEGKLIQINISRADGNVHYGWRLKNGLDHIYRGREEPCFEGEQCLIKIQPEDWPTDCKADHTNTFRFLSRSQKSIAVGRTLKAFFSWSLTDPLGNEAPGGYCLEKWMLVASELKCFGNTAIAKCNQNHDSEFCDMLRLFDYNKNAIKTLNEETKTRVNVLSHTINALISDNLLMKNKIRELMSVPYCNYTRFWYVNHTLSGQHSLPRCWMIRNNSYLNSSEFRNEWILESDFLISEMLSKEYSERQGRTPITLVDICFWSTVFFTSTLFLHLIGFPTHEHIRGEGCPLPHRLNSMGGCRCGKYLPLKKPTIWHRRH
What is the function of this protein?
Interacts with the host receptor.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: HCAB_ECOBW
Sequence: MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRAVDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIASEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLTSRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
What is the function of this protein?
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
What are the official names of this protein?
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase, CI-dihydrodiol dehydrogenase, Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, PP-dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PURR_KLEP7
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIESVEKSCFQKGYTLILGNAWNDLEKQRAYLSMMAQKRVDGLLVMCSEYPDSVLSMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFQGGYIAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMQAMKEAHISVPENWIVQGDFEPESGYRAMQQILNQQHRPTAVFCGGDIMAMGAICAADEMGLRVPQDISLIGYDNVRNARYFSPALTTIHQPKDSLGEAAFNMLLDRIVNKREESQSIEVHPRLVERRSVADGPFVDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: PDXA2_SALTY
Sequence: METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRAIERVAEARFAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTLSTARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSIKLAMQLA
What is the function of this protein?
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP) (PubMed:27402745).  Can also use 4-hydroxy-L-threonine 4-phosphate as substrate (PubMed:27294475, PubMed:27402745).
What are the official names of this protein?
D-threonate 4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase, 4PHT dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family. PdxA2 subfamily.
Protein: RS10_BRUMB
Sequence: MNGQNIRIRLKAFDHRILDASTREIVSTAKRTGANVRGPIPLPTRIEKFTVNRSPHIDKKSREQFEMRTHKRLLDIVDPTPQTVDALMKLDLSAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CALR_EUGGR
Sequence: MRKELWLGLLLSSQAVLSTIYYKETFEPDWETRWTHSTAKSDYGKFKLTSGKFYGDKAKDAGIQTSQDAKFYAISSPIASSFSNEGKDLVLQFSVKHEQDIDCGGGYLKLLPSVDAAKFTGDTPYHIMFGPDICGATKKIHFILTYKGKNLLWKKEPRCETDTLSHTYTAVIKADRTYEVLVDQVKKESGTLEEDWEILKPKTIPDPEDKKPADWVDEPDMVDPEDKKPEDWDKEPAQIPDPDATQPDDWDEEEDGKWEAPMISNPKYKGEWKAKKIPNPAYKGVWKPRDIPNPEYEADDKVHIFDEIAAVGFDLWQVKSGTIFDNIIVTDSLAEAKAFYDQTNGATKDAEKKAFDSAEADKRKKEEDERKKQEEEEKKTAEEDEDDDDEEEEEDDKKDEL
What is the function of this protein?
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle.  This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).
What are the official names of this protein?
Calreticulin.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: LDHB_ANGRO
Sequence: MASVMQKLITPLCSGPQRPRNKVTVVGVGQVGMACAVSILMRELADELALVDVIEDKLKGEMMDLQHGSLFLKTSKIVADKDYSVSANSRIVVVTAGVRHREGESRLNLVQRNVNIFKHIIPQIVKYSPDCILVVVSNPVDVLTYVTWKLSGLPKHRVIGSGTNLDSARFRYLMAEKLGIHSSSFNGWILGEHGDSSVPVWSGANVAGVNLQKLNPDIGTDADKENWKDAHKMVVESAYEVIRLKGYTNWAIGLSVADLAETLIKNLNRIHPVSTMVKGMYGIGDEVYLSLPCVLNNGGVNSVVNMTLTDEEIAQLKKSADTLWGIQKDLKDL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase B chain, LDH-B.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.