PharMolix/UniProtQA huggingface dataset:
Protein: DAPEL_STRZJ
Sequence: MLDLIQTRRDLHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQIRTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLPFASQHQGRMHACGHDFHMTIALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEDDAFGDWLPDQFYGLHVRPDLKVGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVAASYFVTQVQSVVSRNVNPIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGVAAAFDMEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDGVMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: RS4_BRADU
Sequence: MTKRSEAKYKIDRRMGQNIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYANISERQFHGIYVEASRLKGDTGENLIGLLERRLDAVVYRAKFVSTIFAARQFINHGHIKVNGRKVNISSYQLKVGDVVEVKEASKQLAHVLEASQLPERDTPDYLDVDHGKMTAKYIRIPGLSDVPFPVQMEPHLVVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LPID_EDWTA
Sequence: MSLLVQVISLVVISVVVIIIPPCGAALGRIKA
What are the official names of this protein?
ilv operon leader peptide, ilvGMEDA operon attenuator peptide.
Protein: RS8_MYCA1
Sequence: MTMTDPIADFLTRLRNANSAYHDEVTLPHSKLKANIAQILKNEGYISDFRTEDARVGKSLIVQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NADK_LACLA
Sequence: MNFGKKVWLIGNSSEKSKKTLNKLSKILKAEHFVFDDINPEIVISVGGDGTLLRAMHMYEYQLDRVRFLGVHTGHLGFYTDFTDEDLFEVVEALYDENPAQAIHYPLIRVQVSFTDGYQIVRHVLNEATIRRASKTMVGDVRISDYLFERFRGDGLSISTPTGSTAYNKSIGGAVVHPRVKAMQVAEIASLNNVVYRTLGSPMIVAEKDTITVCPAPEDDYSLTFDQLTFEYKNIKSIEFSLDGTTISFANCAHTPFWERVSKSFIGEVE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPIB3_HUMAN
Sequence: MLALWSLLLLWGLATPCQELLETVGTLARIDKDELGKAIQNSLVGEPILQNVLGSVTAVNRGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKVLLKLLPGFGVQLSLHTKVGMHCSGPLGGLLQLAAEVNVTSRVALAVSSRGTPILILKRCSTLLGHISLFSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVSLGALGSVEFSLATLPLISNQYIELDINPIVKSVAGDIIDFPKSRAPAKVPPKKDHTSQVMVPLYLFNTTFGLLQTNGALDMDITPELVPSDVPLTTTDLAALLPEALGKLPLHQQLLLFLRVREAPTVTLHNKKALVSLPANIHVLFYVPKGTPESLFELNSVMTVRAQLAPSATKLHISLSLERLSVKVASSFTHAFDGSRLEEWLSHVVGAVYAPKLNVALDVGIPLPKVLNINFSNSVLEIVENAVVLTVAS
What is the function of this protein?
May have the capacity to recognize and bind specific classes of odorants.  May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites.  May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
What are the official names of this protein?
BPI fold-containing family B member 3, Ligand-binding protein RYA3, Long palate, lung and nasal epithelium carcinoma-associated protein 3.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic.
Protein: AGP1_ORYSJ
Sequence: MARLHLVVVAMAALFAAAAVAQGPSASPTPAPKAQPPVATPPTRPPAVAPVSPPAAQPPVTTPPPVSAPAPVPAPSAAATPSPQASAPTAEPPVLSPPAPAPGSISQSPTEAPTSPPPPSAASGVSPSAAAVVAAWAAVAAVAAFY
What is the function of this protein?
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
What are the official names of this protein?
Arabinogalactan protein 1, OsAGP1.
What is the protein family that this protein belongs to?
Belongs to the classical AGP family.
What are the subcellular locations of this protein?
Vacuole, aleurone grain membrane; Lipid-anchor, GPI-anchor.
Protein: HRCA_BACAN
Sequence: MLTERQLLILQTIIDDFIGSAQPVGSRTLAKKDEITYSSATIRNEMADLEELGFIEKTHSSSGRVPSEKGYRFYVDHLLAPQNLPNDEIVQIKDLFVERIFEAEKIAQQSAQILSELTNYTAIVLGPKLSTNKLKNVQIVPLDRQTAVAIIVTDTGHVQSKTITVPESVDLSDLEKMVNILNEKLSGVPMSELHNKIFKEIVTVLRGYVHNYDSAIKMLDGTFQVPLSEKIYFGGKANMLSQPEFHDIHKVRSLLTMIDNEAEFYDILRHKQVGIQVKIGRENSATAMEDCSLISATYSIGEEQLGTIAILGPTRMQYSRVISLLQLFTRQFTDGLKK
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SYM_SALPA
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLGHKVNTFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YODQ_BACSU
Sequence: MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAVVLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNGHIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKGDVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAWPSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWLPNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKTAHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE
What are the official names of this protein?
Uncharacterized metallohydrolase YodQ.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: RS4_BARBK
Sequence: MSKRESAKYKIDRRIGENIWGRPKSPVNRREYGPGQHGQRRKGKLSDYGVQLCAKQKLKGFYGDISEKQFRKIYQEAVRRRGDTGENLIGLLESRLDAIVYRSKFVPTIFASRQFINHGHVNVNGRRTNIQSYRCKPGDVIEIRERSKQLLLVLEATQLNERDVPDYIEADHSKMKATFVRIPAFSDVPYAVQMEPNLVVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: HFQ_RHOPA
Sequence: MAADRAQNLQDTFLNHVRKTKTPLTIFLVNGVKLQGIVTWFDNFCLLLRRDGHSQLVYKHAISTIMPGAPIQLFESGEDSPA
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: PETL_AETCO
Sequence: MPTLTSYFGFLLAALTITSALFIGLSKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CDPAS_PYRIL
Sequence: MDLLYFFLLIWPPYVANGSAVLANKFKIRHPIDFGKTFVDGRRIFGDGKTYEGFLIGLSTGTFIGYAPNLLYKHLSLLDAFVLSIAALLGDLFGAFIKRRLCMPRGYPAFPLDQLDFLLTSLAVYTLYKDISVEYIIAAVIITPLIHRITNYIAYYLRLKKEPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CARA_BRUA2
Sequence: MTETTPKTAPWTVQKRTAVLVLADGTVIEGKGLGATGAVEAEVVFNTALTGYEEILTDPSYAGQIVTFTFPHIGNVGANAEDIEDLTPANRHGAVGAIFKADITAPSNFRAAKDLDSWLKHRGIIALAGIDTRALTALIRERGAQNAVIAHDPNGNFDLDALKARAANWCGLENLDLAKDVTIGQSLVWKELPWTLQDGYGEQDAPQYHVVALDFGVKRNILRLLTGLGAKVTVLPATATAEDVLAHNPDGVFLSNGPGDPAATGEYAVPTIGKLVETGIPLFGICLGHQMLALALGGRTEKMHQGHHGANHPVKDYTTGKVEIVSMNHGFAVDSDSLPENVEETHVSLFDGTNCGLRVVGKPVFSVQHHPEASPGPQDSHYLFRRFINLIRERKGQAPLPEREQAA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: ISPE_SALTY
Sequence: MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVNGVENEDNLIVRAARLLMKVASESGRLPAGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEILTPVNPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKCEFSNDCEVIARKRFREVDAALSWLLEYAPSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ARLR_STAA8
Sequence: MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
What is the function of this protein?
Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence.  ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin).  Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG).  Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.
What are the official names of this protein?
Response regulator ArlR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAGH_STAHJ
Sequence: MSVSVNINNVTKEYRIYRNNKERIKDALIPKNKNNTFFALDDVSITAHEGDVIGLVGINGSGKSTLSNMIGGSISPTSGNIERNGEVSVIAINAGLNGRLTGVENIEFKMLCMGFKRKEIKQLMPQVIEFSELGEFIHQPVKNYSSGMRAKLGFSINVTINPDILVIDEALSVGDQTFTQKCLDKIYEFKEANKTIFFVSHNIRQVREFCTKIAWIEGGKLKEYGDLEEVLPKYEQFLKDFKKKSKADQKAFRKGLDEKRFIVK
What is the function of this protein?
Part of the ABC transporter complex TagGH involved in teichoic acids export.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Teichoic acids export ATP-binding protein TagH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3.A.1.104.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURA2_STAAN
Sequence: MAQEVIKIRGGRTLNGEVNISGAKNSAVAIIPATLLAQGHVKLEGLPQISDVKTLVSLLEDLNIKASLNGTELEVDTTEIQNAALPNNKVESLRASYYMMGAMLGRFKKCVIGLPGGCPLGPRPIDQHIKGFKALGAEIDESSTTSMKIEAKELKGAHIFLDMVSVGATINIMLAAVYATGQTVIENAAKEPEVVDVANFLTSMGANIKGAGTSTIKINGVKELHGSEYQVIPDRIEAGTYMCIAAACGENVILNNIVPKHVETLTAKFSELGVNVDVRDERIRINNNAPYQFVDIKTLVYPGFATDLQQPITPLLFMANGPSFVTDTIYPERFKHVEELKRMGANIEVDEGTATIKPSTLHGAEVYASDLRAGACLIIAGLIAEGVTTIYNVKHIYRGYTDIVEHLKALGADIWTETV
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_STRPI
Sequence: MSIRVIIAGFKGKMGQAACQMVLTDSDLDLVAVLDPFESESEWQGIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBM_ADICA
Sequence: MEVNILAFVATALFILIPTAFLLILYIQTAAQNNG
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NU3C_NUPAD
Sequence: MFLLHEYDIFWAFLMISSVIPILAFIISGVLAPISEGPEKLSSYESGIEPIGDAWIQFRIRYYMFALVFVVFDVETVFLYPWAVSFDVLGVSVFIEALIFVLIPVVGSVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SYR_ACIAC
Sequence: MLSVKQELLAALAGELEKLSPGSAGRAAFESPKVAAHGDFACTAAMQLAKPLKLNPRALGEQLKAALEATPAFARWVDAIEIAGPGFLNIRLKAAAKQEIVREVLSAGDRFGYQKDNGQRVLVEFVSANPTGPLHVGHGRQAALGDAICNLFSTQGWSVHREFYYNDAGVQIDTLTKSTQLRARGFKPGDECWPTDPENPASKTFYNGDYIQDIANDFLAKKTVKADDREFTANGDVEDYDNIRQFAVAYLRNEQDKDLQAFNLHFDQYYLESSLYTSGRVEATVNRLVEKGHTYEQDGALWLKSTDYGDDKDRVMRKKDGTYTYFVPDVAYHIAKWERGFAKVVNIQGTDHHGTIARVRAGLQAADVGIPQGYPDYVLHTMVRVVKGGKEVKIGKRAGSYVTLRDLIEWTSKDAVRFFLLSRKPDTEYTFDVDLAVAQNNDNPVYYVQYAHARIQSVLRAWAEAGGGDVASLKDVDLSALEGPQAQALMLQLAKYPEMLTAAAEGEAPHDVTFYLRDLAASYHSYYDAERILVDDEAVKRARLALVAATAQVLHNGLKVLGVDAPARM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPSF3_HUMAN
Sequence: MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFNLLCYQLQKLTGDVEELEIQEKPALKVFKNITVIQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEIMLQDIFGEDCVSVKDDSILSVTVDGKTANLNLETRTVECEEGSEDDESLREMVELAAQRLYEALTPVH
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease (PubMed:30507380).  Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380).  U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs.  Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides.  The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site.  Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.  Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380).  Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity).  Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity).  Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 3, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.
Protein: LYSM_SULTO
Sequence: MADVDESDLKILEILRKNARTPYTSIAKELKISEAAVRKRIEKLIKMGVIKRFTIDYELENEIRAIVMVKTNPQIPTPEISKKIIKIQGVEFVYETTGDYDILTVVRGTNISSINKTIDDIRSLQGVLSTNSTIVLRVWF
What is the function of this protein?
In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha-aminoadipate (AAA) pathway.
What are the official names of this protein?
HTH-type transcriptional regulator LysM.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1819_CAMC5
Sequence: MFEGFDFSKMGEVLEKAKEQAAALEAESLNKEFGAKSGGGLVSVKANGKGEILDITIDDSLLEDKESLQILLISAINDVLKMAEDDKKAIAGRMLGGLGDFGFKG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Ccur92_18190.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y181_BRASB
Sequence: MAKAEHTSTAKPSKPAAPERVAAFRTGLSAEARAAALLIAKGYRILAKRFRTPHGEIDIIARKRDLVTFVEVKARASLDDAAYAVTPRQQQRIIDAAQAWLMTHPEHAEFELRFDAILVAPRSLPRHLIAAFDAST
What are the official names of this protein?
UPF0102 protein BBta_0181.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PURQ_LISMH
Sequence: MKFAVIQFPGSNCDLDMLHAIRDSIGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTGAIAKFSSIMPEVLRFAEMGKPVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVANASTMFTELYEEGEIIQVPVAHGEGNYYCDDETLLKLKENNQIVFTYDSVNPNGSRADIAGIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG14_SCHPO
Sequence: MLHVNKCQLCETRRPSICESCLKKQLYDFYHKRDEFSRDIESELEKVAKLKSESFSLKGKITQKEELTYRLQNLAASLNEKKSLSCDLHSRKQLIEDDLSNRKKSINIASQKLAGLSHSTSDYFSKEYLTAYRRSELLQNKLHEYQKKLITRVLDMYQLHWQRDLVLNTQGCTQKSAQMGSEFNPDSIDSSLAYRLSKLSMGNSKSDLSHSDNETGHFYSNFFSQVMELNASVTISGIPVCIRSKEKMFLNPDCALTLSFICIFLAQYTSIPLPCPLQLPSPDQKPMTSFSSEQMLYIMYNIVWISWNCGIFSFPRGITQSQLFELMQYTGFWLVQLRTKPLTSQKPDWHYKMGMDFDLFHRLYLARLPIPINYSSLRSRSSSKPYQLIS
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific vps34 PI3-kinase complex I.  This complex is essential to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the preautophagosomal structure.  Atg14 mediates the specific binding of the vps34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).
What are the official names of this protein?
Autophagy-related protein 14.
What is the protein family that this protein belongs to?
Belongs to the ATG14 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.