PharMolix/UniProtQA huggingface dataset:
Protein: NRDI_MYCLB
Sequence: MQAHNLVYFSSVSENTHRFVQKLGVPAMRIPLHSRIEVSDPYVLVLPTYGGGRTAPDLQAGGYVPKQVIAFLNNEYNRALICGVVAAGNTNFGAEFCYAGDVVARKCGVPYLYRFELMGTEDDVTAVRAGLANLWKEH
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: SERHL_DANRE
Sequence: MLPAFMSLRHFTTTTMRRAASEFRMPVPWGELRGQVWGPSHGRPVLCLHGWADNSGTFNTLVPLLPNDWRFVAIDFPGHGLSSHRPDGCFYAFPFYVADVRRVVEALQWKRFSIIGHSMGGNVAGMFSALYPEMVESVVLLDTYGFLPTEVTDMFTNMRKGINDQIQYDNMANERKERVYTYEKAKERLKVANPYLSDQSADILLERAVREVDGGFVFTRDFRINLKNIIYINIDQCLHVLSQVKAKVMLLLAKDGLFKTFTLPDGYADRICKSWTDQKATFVEVEGDHHVHLNNPEAVSSVITDFLQPQSPDQTESQSGNQTSRL
What is the function of this protein?
Probable serine hydrolase.
What are the official names of this protein?
Serine hydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: CATB_ACIAD
Sequence: MYKSVETILVDIPTIRPHKLSVTTMQTQTLVLIKIITEDGIVGWGEATTIGGLNYGEESPESVKANIDTYFKPLLLSIKAPLNVAQTLKLIRKSINGNRFAKCAIQTALLEIQAKRLNVPVSELLGGRIRDRLPVLWTLASGDTDKDIAEAKKMIELKRHNTFKLKIGSNPLQHDVDHVIAIKKALGPEISVRVDVNRAWSELECVKGIQQLQDGGIDLIEQPCAIENTDALARLTARFDVAIMADEVLTGPDSAYRIAKKSGADVFAVKVEQSGGLIEACEVAKIARLAGISLYGGTMLEGPVGSIASAHAFSTFETLEFGTELFGPLLLTQSILKTPLQYENFELVVPNTPGLGIEVDEDKLEQLRRH
What is the function of this protein?
Catalyzes a syn cycloisomerization.
What are the official names of this protein?
Muconate cycloisomerase 1, Cis,cis-muconate lactonizing enzyme I, MLE, Muconate cycloisomerase I.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: TM7S3_HUMAN
Sequence: MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISSNVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPVQNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKTSVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERTPLLL
What is the function of this protein?
Involved in the inhibition of cytokine-induced death of pancreatic beta cells.  Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325).  Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress.  Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
What are the official names of this protein?
Transmembrane 7 superfamily member 3, Seven span transmembrane protein.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS5_CORGL
Sequence: MTKTVALLDYGSGNLRSAQRALERAGAEVIVSSDPEVCTNADGLLVPGVGAFDACMKGLKNVFGHRIIGQRLAGGRPVMGICVGMQILFDEGDEHGIKSAGCGEWPGKVERLQAEILPHMGWNTLEMPTNSPMFEGISPDERFYFVHSYGVRKWTLETDDLTTPPEVVWAKHENDRFVAAVENGTLWATQFHPEKSGDAGAQLLRNWINYI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_ROSS1
Sequence: MYAIVRDRGMQYRVEEGQALDIALLDAEPGSEIELGDVLLIGGEQPRVGTPTVDGAKVVATVLGTIKGDKIVVFRYKNKKRYRRRTGHRQEYTRVSISKIIVDADEQHVTGSMEGETNGA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RK36_BARVE
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MET1_ARATH
Sequence: MSLAPSSYPSLYSSPSLPRTQQTKQNPSLITQSSFISAKSLFLSSNSASLCNTHVAKRRNLALKASETESSAKAEAGGDGEEEEKYETYEIEVEQPYGLKFRKGRDGGTYIDAILPGGSADKTGKFTVGDRVIATSAVFGTEIWPAAEYGRTMYTIRQRIGPLLMQMEKRNGKAEDTGELTEKEIIRAERNAGYISSRLREIQMQNYLKKKEQKAQREKDLREGLQFSKNGKYEEALERFESVLGSKPTPEEASVASYNVACCYSKLNQVQAGLSALEEALKSGYEDFKRIRSDPDLETLRKSKDFDPLLKQFDESFINESAINAIKSLFGFNKK
What is the function of this protein?
Involved in photosystem II supercomplex formation and repair, probably acting as a psbB/psbC chaperone on the stromal side of the membrane.
What are the official names of this protein?
Protein MET1, chloroplastic, PDZ domain, K-box domain, and TPR region containing protein.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=In thylakoids, enriched in stroma lamellae, and also present in grana.
Protein: CAVN4_MOUSE
Sequence: MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS
What is the function of this protein?
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation.  Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387).  Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963).  Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).
What are the official names of this protein?
Caveolae-associated protein 4, Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein.
What is the protein family that this protein belongs to?
Belongs to the CAVIN family.
Protein: T23O_BURP6
Sequence: MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAAERLDADWTQPTRHDRTVEAAWLAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: TOLB_XANCP
Sequence: MKKPLRWLAALTALLLPLSAFAQQQGLTIDIVGGSASATPITVVPMPYQGSGTAPQTDVSAVVSADLDRSGQFRTLPAAQIVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVEYELFDVAKGERLLGLAMTARANAMRDVSHQMADAIYEKVTGVRGAFWTRIAYVTASGSGGSMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIASGARELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWAPDGGSIYFTSDRGGRPQIYQVAASGGSANRVTFQGNYNATASVSFDGKKVAVAQGSGNTYRIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAREGGRGVLYAVSADARVRQRLVLADGDVREPAWGPYRTAH
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: THIKB_RAT
Sequence: MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGRRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKLKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN
What is the function of this protein?
Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:10064897, PubMed:2882519).  Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:10064897, PubMed:2882519).  Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:10064897, PubMed:2882519).  Medium chain straight 3-oxoacyl-CoAs are preferred substrates (PubMed:10064897).
What are the official names of this protein?
3-ketoacyl-CoA thiolase B, peroxisomal, Acetyl-CoA acyltransferase B, Beta-ketothiolase B, Peroxisomal 3-oxoacyl-CoA thiolase B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: CLPP_CALFG
Sequence: MPIGVPKVPFRSPGEEDAVWVDVYNRLHRERLLFLGQEVDSEISNQLVGLMVYLTIEDDTKDLYLFINSPGGWVIPGIAIYDTMQFVSPDVHTICMGLAASMGSFILVGGEITKRLAFPHARVMIHQPASSFYEAPTGEFILEAEELLKLRETLTRVYVQRTGNPLWVVSEDMERDVFMSATEAQAHGIVDLVAIENTGDSA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: PURA_PROM1
Sequence: MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVEDKVLKLHLIPSGILYPDTICLIGSGTVVDPKVMIKEIKMLEDNDIDISGLKLASTAHVTMPYHRLLDLAMEQKRGDQKIGTTGRGIGPTYADKSQRNGIRIIDLMSREKLQERLQVPLSEKNGLLQKIYGIEPLIIDEIIEEYLDYGKQLKKHIVDCNRTIHQAARKKKNILFEGAQGTLLDLDHGTYPYVTSSNPVSGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELHGSINDQLCDRGGEFGTTTGRRRRCGWFDGVIGKYAVEVNGLDCLAITKLDVLDELEEIDICVAYELNGKRIDYFPTSVEDFEKCNPIFKKLPGWRCSTENCRRLEDLPPAAMSYLRFLAELMEVPIAIVSLGANRDQTIVIEDPIHGPKRALLNS
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFA2E_ORYSJ
Sequence: MNYRVVNPVKVESGPSTGVANGQPPRPMDGLADGGPPPFLTKTYDMVDDPTTDAVVSWSATNNSFVVWDPHLFGNVLLPRYFKHNNFSSFVRQLNTYGFRKVDPDKWEFANEGFLRGQKHLLKSIKRRKPPNSSPSQQSLGSFLEVGHFGYEGEIDQLKRDKHLLMAEVVKLRQEQQNTKSDLQAMEQKLQGTEQKQQHMMAFLSRVMHNPEFIRQLFSQSEMRKELEEFVSKKRRRRIDQGPELDSMGTGSSPEQVSQVMFEPHDPVDSLFNGVPSDLESSSVEANGGKAQQDVASSSSEHGKIKPSNGELNEDFWEDLLHEGGLDEDTRNPAIDDMNLLSQKMGYLNSSSTKSPQ
What is the function of this protein?
Transcriptional activator expressed upon environmental stress that specifically binds DNA of heat shock promoter elements (HSE).  Involved in heat stress response.
What are the official names of this protein?
Heat stress transcription factor A-2e, Heat stress transcription factor 12, OsHsf-12.
What is the protein family that this protein belongs to?
Belongs to the HSF family. Class A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMH_BRADU
Sequence: MRVAVIAVGRLKQGPERELADRYFERFDEAGRKLGFRELSIHEIPESRARDAATRMAEEAAAIGAYIPDKSILVALDERGQNLDSTVFARHLGRWRDEGAGHTIFVIGGADGLSPELRRKAKLAIAFGSATWPHQMVRVMLLEQLYRAATILAGHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHCAF_CHICK
Sequence: MFGFRKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQNCFGLHEARSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKMKTLSGSRIKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDEGSDTEMSAGSSRTPVFSFLDLTYWKRQKVCCGIIYKGRFGEVLIDTHLFKPCCSNKKSATEKPEQEGPQSPAISTQEEW
What is the function of this protein?
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.  Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells and is essential to maintain the complex on chromatin.
What are the official names of this protein?
SIN3-HDAC complex-associated factor, Protein FAM60A, Tera protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SINHCAF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RELE4_CAUVC
Sequence: MAQDVGHAAPDTATIFVAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVIGSVRHGARRPI
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Its toxic effect is neutralized by coexpression with cognate antitoxin RelB4 but no other ParD or RelB antitoxin.
What are the official names of this protein?
Toxin RelE4.
What is the protein family that this protein belongs to?
Belongs to the RelE toxin family.
Protein: PARM1_RAT
Sequence: MVCKALITLCIFAAGLRVQGSPTPTLLPVSLTTKSTAPMATWTTSAQHTAMATTPVASATHNASVLRTTAASLTSQLPTHPREEAVTSPPLKREVNSTDSSPTGFSSNSSGIHLAPTPEEHSLGSPETSVPATGSQSPTLLFSQGPTSASTSPATSPSEPLSASVTSNHSSTVNNIQPTGAPMAPASPTEEHSSSHTPTSHVTEPVPKEKSPQDTEPGKVICESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGAAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS
What is the function of this protein?
May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.
What are the official names of this protein?
Prostate androgen-regulated mucin-like protein 1 homolog, PARM-1, Castration-induced prostatic apoptosis-related protein 1, CIPAR-1, Prostatic androgen-repressed message 1 protein.
What is the protein family that this protein belongs to?
Belongs to the PARM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
Protein: RL35_SALRD
Sequence: MPKMKSHSGAKKRFKKTGNGKIKRKKANKGHLLTKKNAKRKRQLRKSVVVDDKANRDRIKRMLST
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: HDHA_PAESO
Sequence: MNKLENKVALVTSATRGIGLASAIKLAQNGAIVYMGVRRLEATQEICDKYKEEGLILKPVFFDAYNIDIYKEMIDTIIKNEGKIDILVNNFGTGRPEKDLDLVNGDEDTFFELFNYNVGSVYRLSKLIIPHMIENKGGSIVNISSVGGSIPDISRIGYGVSKSGVNNITKQIAIQYAKYGIRCNAVLPGLIATDAAMNSMPDEFRKSFLSHVPLNRIGNPEDIANSVLFFVPSEDSSYITGSILEVSGGYNLGTPQYAEFVGSKVVE
What is the function of this protein?
7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as the major human bile acids cholate and chenodeoxycholate, to the corresponding 7-oxosteroids (PubMed:8050999, PubMed:11947357).  Is thus liley involved in the metabolism of primary bile acids (PubMed:8050999).
What are the official names of this protein?
7alpha-hydroxysteroid dehydrogenase, 7alpha-HSDH, NADP-dependent 7alpha-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: EMC4_HUMAN
Sequence: MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231).  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835).  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
What are the official names of this protein?
ER membrane protein complex subunit 4, Cell proliferation-inducing gene 17 protein, Transmembrane protein 85.
What is the protein family that this protein belongs to?
Belongs to the EMC4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus.
Protein: RL13_ECOSE
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SEUSS_ARATH
Sequence: MVPSEPPNPVGGGENVPPSILGGQGGAPLPSQPAFPSLVSPRTQFGNNMSMSMLGNAPNISSLLNNQSFVNGIPGSMISMDTSGAESDPMSNVGFSGLSSFNASSMVSPRSSGQVQGQQFSNVSANQLLAEQQRNKKMETQSFQHGQQQSMQQQFSTVRGGGLAGVGPVKMEPGQVSNDQQHGQVQQQQQKMLRNLGSVKLEPQQIQAMRNLAQVKMEPQHSEQSLFLQQQQRQQQQQQQQQFLQMPGQSPQAQMNIFQQQRLMQLQQQQLLKSMPQQRPQLPQQFQQQNLPLRPPLKPVYEPGMGAQRLTQYMYRQQHRPEDNNIEFWRKFVAEYFAPNAKKRWCVSMYGSGRQTTGVFPQDVWHCEICNRKPGRGFEATAEVLPRLFKIKYESGTLEELLYVDMPRESQNSSGQIVLEYAKATQESVFEHLRVVRDGQLRIVFSPDLKIFSWEFCARRHEELIPRRLLIPQVSQLGSAAQKYQQAAQNATTDSALPELQNNCNMFVASARQLAKALEVPLVNDLGYTKRYVRCLQISEVVNSMKDLIDYSRETRTGPIESLAKFPRRTGPSSALPGPSPQQASDQLRQQQQQQQQQQQQQQQQQQQQQQQQTVSQNTNSDQSSRQVALMQGNPSNGVNYAFNAASASTSTSSIAGLIHQNSMKGRHQNAAYNPPNSPYGGNSVQMQSPSSSGTMVPSSSQQQHNLPTFQSPTSSSNNNNPSQNGIPSVNHMGSTNSPAMQQAGEVDGNESSSVQKILNEILMNNQAHNNSSGGSMVGHGSFGNDGKGQANVNSSGVLLMNGQVNNNNNTNIGGAGGFGGGIGQSMAANGINNINGNNSLMNGRVGMMVRDPNGQQDLGNQLLGAVNGFNNFDWNA
What is the function of this protein?
DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development.  Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function.  Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression.  In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms.  Controls cell division during petal development and enable the proper patterning of petal blade vasculature.  Required for the proper elaboration of petal polarity along the adaxial/abaxial axis.  May act through direct or indirect regulation of PHABULOSA and YAB1 and thus regulate cellular proliferation within the developing petal blade.  In association with AINTEGUMENTA (ANT), coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium.  Required for the development of the medial ridge and subsequent ovule initiation.
What are the official names of this protein?
Transcriptional corepressor SEUSS, AtSEU.
What is the protein family that this protein belongs to?
Belongs to the adn1/SEU family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Does not localize in the nucleolus.
Protein: PARB_PSEPU
Sequence: MAVKKRGLGRGLDALLSGPSVSALEEQAVKIDQKELQHLPVELVQRGKYQPRRDMDPEALEELAHSIRNHGVMQPIVVRPIGDNRYEIIAGERRWRATQQAGLDTIPAMVREVPDEAAIAMALIENIQREDLNPLEEAMALQRLQQEFELTQQQVADAVGKSRVTVANLLRLITLPDAIKTMLAHGDLEMGHARALLGLDENRQEEGARHVVARGLTVRQTEALVRQWLSDKPDPVEPSKPDPDIARLEQRLAERLGSAVQIRHGNKGKGQLVIRYNSLDELQGVLAHIR
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication.  Binds to the DNA origin of replication (By similarity).
What are the official names of this protein?
Probable chromosome-partitioning protein ParB.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: TM101_MOUSE
Sequence: MASKIGSRRWMLQLIMQLGSVLLTRCPFWGCFSQLMLYAERAEARRKPDIPVPYLYFDMGAAVLCASFMSFGVKRRWFALGAALQLAISTYTAYIGGYVHYGDWLKVRMYSRTVAIIGGFLVLASGAGELYRRKPRSRSLQSTGQVFLGIYLICVAYSLQHSKEDRLAYLNHLPGGELMVQLFFVLYGVLALAFLSGYYVTLAAQILAVLLPPVMLLIDGNVSYWHNTRRVEFWNQMKLLGESVGIFGAAVILATDG
What is the function of this protein?
May activate NF-kappa-B signaling pathways.
What are the official names of this protein?
Transmembrane protein 101.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MDH_SHEB9
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSHLSLYDIAPVTPGVAVDLSHIPTAVEIKGFAGEDPTPALVGADVVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVAATCPTALVGIITNPVNTTVAIAAEVMKKAGVYDKNRLFGITTLDVIRSETFIAELKSLNVADVKVNVIGGHSGVTILPLLSQVEGVTFTDEEVASLTTRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLSLVRGLQGEANIVECAYVDGGSEHAEFFAQPVLLGKNGIEKVLPYGEVSAFEANARDSMLDTLKGDIKLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.