PharMolix/UniProtQA huggingface dataset:
Protein: RS10_PSECP
Sequence: MAGQKIRIRLKSYDHEVIDVSARKIVETVTRAGATVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKAVDSLMRLDLPADVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PSF1_XENLA
Sequence: MFCEKAIELIRELQRASDGQLPAFNEDGIRQILEEMKALYEQNQADVNEAKTEGRSDLIPTIKFRHCCLLRNRRCIVAYLYDRLLRIRALRWEYGSVLPSALRFHMSTEEMDWFNQYKRSLATYMRSLGGEEGLDITQDMKPPKSLYIEVRCLRDYGEFEIDDGTTILLKKNSQHFLPRWKCEQLIRQGVLEHVLS
What is the function of this protein?
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks.  GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
What are the official names of this protein?
DNA replication complex GINS protein PSF1, GINS complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin.
Protein: MUTH_VIBVU
Sequence: MKPIPQTEAELLQRANQIAGCSFAELAEEANMDVPLDLKRDKGWVGQLLEWHLGAPAGSKPQQDFSELGIELKSIPVSYSGKPLETTFVCVAPLTGVHGLTWETSHVRNKLSRVLWIPVEGEREIPLAERHVGTPLLWSPNDEEEILLKNDWEELMEMIVFGQFDQISARHGVALHLRPKAANSKALTEAYNINGKPIKTLPRGFYLRTQFTAQILQNAFNSLLNEE
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDUK_CITFR
Sequence: MKQSLGLLEVSGLALAISCADVMAKAASITLVGLEKTNGSGWMVIKIIGDVASVQAAISTGVSFADQRDGLVAHKVISRPGDGILSHSVTPESESEPAPAPTPVVPHEEIPEDHAAPEAPQDAELISCNLCLDPACPRQKGEPRSLCLHSGKRGEA
What is the function of this protein?
The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Bacterial microcompartment shell protein PduK, Propanediol utilization protein PduK.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: PUR9_PSESM
Sequence: MTDQTTRLPIRRALISVSDKTGILEFARELEALGVEILSTGGTFKLLQDNGVAAVEVADYTGFAEMMDGRVKTLHPKIHGGILGRRGIDDAIMNEHGIKPIDLVAVNLYPFEATVSKPGCDLPTAIENIDIGGPTMVRSAAKNHKDVAIVVNAGDYGQVLESLKAGGLTYAQRFDLMLKAFEHTAAYDGMIANYLGGVDQTADTLSTEGRSQFPRTFNTQFVKAQEMRYGENPHQSAAFYVEAKPAEVGIATATQLQGKELSFNNVADTDAALECVKSFVKPACVIVKHANPCGVAVCPDDEGGIRQAYELAYATDSESAFGGIIAFNRELDAATAKAIVERQFVEVIIAPSVSAEARSIIASKANVRLLTSGQWSERLPAWDYKRVNGGLLVQSRDIGMITEADLKVVTQRAPTEHEMHDLIFAWKVAKYVKSNAIVYARNRQTIGVGAGQMSRVNSARIAAIKAEHAGLQVQGAVMASDAFFPFRDGIDNAAKVGISAVIQPGGSMRDNEVIAAADEAGIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: UREE_STAAW
Sequence: MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYGDILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVEDLLKSLGIPYVREDRKVNKAFRHIGHSHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C74A2_PARAR
Sequence: MDPSSKPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDYFQSVATPVMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFPNTLKWIGLAGENLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIELGESPLGAAVTLTFLKRASI
What is the function of this protein?
Involved in the biosynthesis of jasmonic acid, a growth regulator that is implicated also as a signaling molecule in plant defense.  Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides (By similarity).
What are the official names of this protein?
Allene oxide synthase, Cytochrome P450 74A2, Rubber particle protein, RPP.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Note=Rubber particle.
Protein: NU5C_VICFA
Sequence: MEYTHQSSWIIPFIPLPVPILIGVGLLLFPTATKNLRRMWAFPSIFLLTIVMIFSIDLSIQQIENSSIYQYVWSWTINNDLSLEFGYLIDSLTSIMSILITTVGILVLIYSDSYMSHDQGYLRFFTYMSFFNTSMLGLVTSSNLIQVYIFWELVGMCSYLLIGFWFTRPIAANACQKAFVTNRVGDFGLLLGILGFYWITGSLEFRDLFQIFKNLIYKNEVNILFVTLCALLLFCGSVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFIVIPSIMSGIALIGIITVVLGATLAIAQKDIKKNLAYSTMSQLGYMMLALGMGSYRAALFHLITHAYSKALLFLGSGSIIHSMEAIVGYSPDKSQNMVLMGGLTKHAPITKMSFLIGTLSLCGIPPFACFWSKDEILNDSWLYSPIFAIIACSTAGLTAFYMFRIYLLVFEGYLNVHFQNFNGKKNSSFYSISLWGKEEKKKLKKKIHLLGFLTMNNNERTSFFRERTYSHRINRNVKSIRRLFLDSTHFGTKNLPFFYPHESDNTMLFSMLVLVLFTFFVGSIGISFSQEGIDLDILSKLLIPSIDLLHQNSKNSVDWYEFFINATFSVSIAFFGLFIASFFYKPVFSSLQNLNLFNLFQKNVPKKIISDKIINILYDWSYNRGYIDAFFEVSLIASVRKLAKFNYFFDRQLIDGIPNGVGISNFFIGEAIKYVGGGRISSYIFFFVLIFLLICYYIYLFP
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS7_BORPE
Sequence: MPRRREVPKREILPDPKFGSVELAKFMNVVMLDGKKAVAERIIYGALEQVQVKTGKDAIEVFNLAINNIKPIVEVKSRRVGGANYQVPVEVRPVRRLALAMRWLREAAKKRGEKSMDLRLAGELIDASEGRGAAMKKREDTHKMAEANKAFSHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: C7A75_MAELA
Sequence: MELLFVSLLSLFLLILLPLSLLFLFPSSFSTTTTEANKNSANLPPGLTGWPVVGESFQFLAAGWRGNPEKFIFDRIAKYSSYVYKTNLMLERTAVFCGAPAHKFLFSNENKLVQSWWPSSVNKIFPSSNQTSSKEEAMKMRKMLPNFFKPEALQGYIGIMDTIAQRHFAADWDNKDYIVVFPLCKRYTFWLACKIFMSIEDPKDVDRFLARFNLVAEGLLSIPIDLPGTPFHHSIKAAEFIREHLVAIIKQRKIDLAEGKASPTQDIMSYMLLTPDEDGKFMKEYDIADKILGLLVGGHDTASSACAFIVKYLAELPQVYQGVYKEQMEIAKSKGPGELLNWDDIQKMKYSWNVACEVLRLAPPLQGAFRDVLKDFMYEGFYIPKGWKVYWSAHSTHKNPEYFPEPYKFDPSRFDGSGPAPYTFVPFGGGPRMCPGKEYARLEILVFMHNLVKRFRWEKLIPDEKIVVNPMPVPEKGLPIRLFSYDA
What is the function of this protein?
Catalyzes the C-28 oxidation of beta-amyrin to form erythrodiol (PubMed:25578277).  Catalyzes the C-28 oxidation of erythrodiol to form oleanolic aldehyde (PubMed:25578277).  Catalyzes the C-28 oxidation of oleanolic aldehyde to form oleanolate (PubMed:25578277).
What are the official names of this protein?
Cytochrome P450 716A75.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HBA_ODORO
Sequence: VLSPADKTNVKTTWDKLGGHAGEYGGEALERTFMSFPTTKTYFPHFDLSPGSAQVKAHGKKVADALTTAVAHIDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPAEFTPAVHASLDKFFSTVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ALFL9_ORYSI
Sequence: MDAQYNPRTVEEVFRDFKGRRAGLVRALTADVEDFFRQCDPEKENLCLYGFPNEHWEVNLPAEEVPPELPEPALGINFARDGMQEKDWLSMVAVHSDAWLLSVAFYFGARFGFDKNDRKRLFGMINDLPTIFEVVSGKSKAKPPSANNHSNSKSKSSNKTKSSEPRAKQPKPQPQPPVKNEGREEEGGPDDEEGGGGGGGGREEEHGETLCGACGESYGADEFWICCDICEKWFHGKCVKITPAKAEHIKQYKCPSCSGGNGGGGGGSGNGKRARPS
What is the function of this protein?
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
What are the official names of this protein?
PHD finger protein ALFIN-LIKE 9.
What is the protein family that this protein belongs to?
Belongs to the Alfin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PKN1_BACSU
Sequence: MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYLAETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQPIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYIIFFLI
What are the official names of this protein?
Probable serine/threonine-protein kinase YabT.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: SSX8_HUMAN
Sequence: MNGDDAFAKRPRDDDKASEKRSKAFNDIATYFSKKEWEKMKYSEKISYVYMKRNYEAMTKLGFNVTLPPFMCNKQATDFQGNYFDNDRNRRIQVERPQMTFGRLQRIIPKIMPKKPAEEGNDSKGVSEASGPQNDGKQLAPGKANTSEKINKRSGPKRGRHAWTHRLRERNQLVIYEEIRDPEEDDE
What is the function of this protein?
Could act as a modulator of transcription.
What are the official names of this protein?
Putative protein SSX8.
What is the protein family that this protein belongs to?
Belongs to the SSX family.
Protein: LPXB_HAEIG
Sequence: MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELSVMGLAEILKHLPRLLKIRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEACQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQFESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RR14_VITVI
Sequence: MARKSLIQRERKRQKLEQKYHLIRRSSKKEISKVPSLSDKWEIHGKLQSSPRNSAPTRLHRRCFLTGRPGANYRYFGLSGHILREMVHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NU4M_LUMTE
Sequence: MLKLQMVLMSLLLLPLIVNLYPWIIALTLSALLLPTCFNLVNSASYSMFTEYMSSDMMSFTLSALTIWVTVMMILASTKIMHLNMYPKMFMTNLVILLIILINCFLSPNLIMFYIWFEASLIPTMVLIMTWGYQPERSQASMYLMIYTVAASLPMLMVLCKIFIVSKTAMMPMFMNMEFPMDYPSMALAWVLTLGGFLVKLPMFTVHLWLPKAHVEAPIAGSMILAAILLKLGGYGILRMLSLFHYMAKSTSSLLSSVALVGAVSTSLICLRQSDLKSLIAYSSVGHMGLMVAGALMSSNWGFQAALAMMIAHGLSSSALFVMANMNYELTHTRSLFLMKGLLVLAPTLTMWWFLFTASNMAAPPSINLLSEIMLITSILKMSTSAFILLGLTSFFTAAYCLYMYTSMHHGPLMLTSNPIPQFKVKDLTLMTMHLVPTILIIFKPELITSWS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: PNP_CORK4
Sequence: MIARGTHREGRIPPFMTNNHSVFYDEEFGTHSVEATIDNGDFGSRTIRLETGQLARQANGSVVAYLDEDTMMLSTTTASSKPREGFDFFPLTVDVEERMYAAGRIPGSFFRREGRPGTDAILACRLIDRPLRPTFVKGLRNEVQVIVTVMSLDPKDMYDVVAINAASASTQLSGLPVSGPVGGVRMALIVDDDHEDGQWVAFPTREQHESALFEMVVAGRLTDEQVPEKPRKGRRRGRKSSPRKKTDNVAIMMVEAGATETVVERVNDGAPAPTESVVAEGIEAAKPFIAELCGAQQALRQAVDPETEEFPLFPPYGADVLAAVDSEAKGRISDIMSIADKQERDEALSSDMDDTVEALLEEFPEREAEIRAAHNAVTKEVVRSRILADGFRIDGRGVEDIRDLDVEVDLVPRAHGSSLFQRGETQILGVTTLDTLKMEQQVDSLGPVDHRRYIHHYNFPPYSTGETGRVGSPKRREIGHGALAERALKPMIPSRDDFPYTIRQVSEALGSNGSTSMGSVCASTLSLYNAGVPLKAPVAGIAMGLVSGEVKGKMTYVTLTDILGAEDAFGDMDFKVAGTEDFITALQLDTKLDGIPSDVLAGALKQAREARLEILNTMAEVIDEPDPMSDYAPRITTISVPVSKIGEVIGPKGKNINQITEDTGARVSIEDDGTVFISATSGGSAEAAVDRINEIANPQLPKVGERFLGTVVKTTAFGAFVSILPNRDGLVHISKLGGKKRIEKVEDVVNVGDKLEVEIADIDNRGKISLVPVDD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGD4_RAT
Sequence: MEESNPAPTSCASKGKHSKVSDLISHFEGGSVLSSYTDVQKDSTMNLNIPQTPRQHGLTSTTPQKLPSHKSPQKQEKDSDQNQGQHGCLANGVAAAQSQMECETEKEAALSPETDTQTAAASPDAHVLNGVRNETTTDSASSVTNSHDENACDSSCRTQGTDLGLPSKEGEPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATELLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKNMTERVPQFKSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVTMCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIMSGFAESEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYIVDDMPKSADLPHSFKLTQSKSVHSFAADSEELKQKWLKIILLAVTGETPDGPSEHLDTLDNLPGPKEKSEC
What is the function of this protein?
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.  Plays a role in regulating the actin cytoskeleton and cell shape.  Activates MAPK8.
What are the official names of this protein?
FYVE, RhoGEF and PH domain-containing protein 4, Actin filament-binding protein frabin, FGD1-related F-actin-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers.
Protein: RS10_SHEB8
Sequence: MQNQRIRIRLKGFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERYTILISPHVNKDARDQYELRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: 3S12_NAJNA
Sequence: LECHNQQSSQTPTTTDCSGGETNCYKKWWSDHRGTIIERGCGCPTVKKGIELNCCTTDRCNN
What is the function of this protein?
Nicotinic acetylcholine receptor antagonist (PubMed:35418867).  Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:35418867).  Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site (PubMed:35418867).  Induces concentration-dependent inhibition of indirect twitches and abolishes contractile responses of tissues to exogenous acetylcholine and carbachol, in the chick biventer cervicis nerve-muscle preparation at 100-300 nM (in vitro) (PubMed:35418867).  Prior incubation of tissues with Indian polyvalent antivenom (1 ml/0. 6 mg) prevents the neurotoxic effects at 100 nM (in vitro) (PubMed:35418867).  Addition of Indian polyvalent antivenom (1 ml/0. 6 mg) at the t90 time point does not reverse the neurotoxic effects (in vitro) (PubMed:35418867).  Displays non-competitive antagonism of concentration-response curves to carbachol, with a pA2 of 8. 01 (in vitro) (PubMed:35418867).
What are the official names of this protein?
Alpha-elapitoxin-Nn2a, Short neurotoxin 2, Short-chain alpha-neurotoxin Nn2a.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CUF2_SCHPO
Sequence: MIIIDGKNYACVVCLRGHRGSSCQHQERALIEVRTRGRPLLCKKCRAIKQQLKSNLKCVCHLQPFLPFANEYQELLNFTQKNPILASLFLFSTDKDIMNSSLNPASQAYTFDLGRTLPISEDILGYRKPLSLTDASNRIDASQLNEKENDSFTINQEADIFNFAKYLHSKDDISGIP
What are the official names of this protein?
Copper-binding regulatory protein cuf2, Copper homeostasis protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL27_VIBCH
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGTNVGIGKDHTLFALSDGKVKFEVKGPNNRKFVSIETAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: TRUB_HISS2
Sequence: MSKPRKKGRDINGIFLLDKSQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQYLLDADKRYQVIAKLGERTDTSDADGQVVQKREVNIDLAKILTALEQFRGEIMQVPTMFSALKYQGKALYEYARAGITIEREARPISIFELKFIDYQIPYLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTRLRRIAVADYPYNKMMTLEQLQQFSEQEDLDLLDQHLLPMESAVIRLPGLHLTKEQARAVGFGQRIKFLNEQGIQGQVRLISPENLFLGVAVIDENSIVHPQRMVVIKPE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: T15BA_XENLA
Sequence: MWAWALLPICLTIWATAGIWIVYGMSVSNGSVNLSDGFPYISLCGTDPPQSCVFGQVLNVGAMLGVWISAIRFQQIRDYNCHSVLNSVSLAMGILCALGTSIVGNFQQSNQLETHLAGAFLAFVIGNIYFWMQTALTYMVKPTHGGCYIGPIRFCLSVACTALIVLMAVFLKMNMKSISAICEWIVAMILFLLYGLFAVDFWHLDGHYFHVKKRTVIPNEMQVSTVTLSI
What is the function of this protein?
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity).  Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity).  May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity).
What are the official names of this protein?
Modulator of macroautophagy TMEM150B-A, Transmembrane protein 150B-A.
What is the protein family that this protein belongs to?
Belongs to the DRAM/TMEM150 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Protein: HPRK_XYLFA
Sequence: MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: NUSB_XANOM
Sequence: MSKPGGHPRHGRRDGIDPVLRSRARRRALQAVYAWQISGGFAKQVIAQFAHEQAHEVADLAYFENLVEGVLTNRAELDTALTPYLDRGVEEVDAIERAVLRLAAYELLYRQDVPYRVVINEAIETAKRFGSEHGHTYVNGVLDRAAVEWRKVESGA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: LPXD_PARXL
Sequence: MAFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLINAEDLARLASRESRNFIVTPNPYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAASAVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLYPNVAVYYGCKLGERVIVHAGAVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEECVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTAKSGVSKSLLKPGMYTSAFPAVNHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAANAASSSAGDKA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: MNMA_HAHCH
Sequence: MSTHRNQRVIVGISGGVDSSVSAYLLKALGYEVEGLFMKNWDEDDGTEYCTALSDLEDAQKVCDKLGIKLHTASFSAEYWDRVFEHFLDEYRAGRTPNPDILCNKEIKFKAFLDYAQALGGDLIATGHYAQFSRFGEHTYLMKGADPSKEQSYFLHAVPGQALARTLFPVGGLLKKEVRRIARELDLITHDKKDSTGICFIGERKFSDFLKTYLPAQPGKIVTDKGEEIGRHQGLMYHTIGQRQGLGIGGLKGYDDAPWYVVEKDLDNNELVVAQGGDHPRLFSAGLTASKLDWINGVPAKSSFSCYAKTRYRQPDQLCRVDVQDGGVRVTFDKRQRAVTPGQSVVFYDGARCLGGGVIESVFK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.