PharMolix/UniProtQA huggingface dataset:
Protein: GATA_PEDHC
Sequence: MLQTSIKKIHGKLKGSNLNTAEVIVNSFKRAEQVLELNSFISMNNNAGLQVESSNEYFKNGKPRSLLEGIPIAVKDNFCVKDTLTTCGSKMLQNFRPKYTATVVQKLLDSGAILVGKTNMDEFAMGSGTTTSIFGPTKNIWGSRFSNLCIQEKNDWFIPGGSSGGSAVAVASGICLGALGSDTGGSCRNPASYCGIVGLKPTYGLLSRYGLIPLVNSMDVPAIMALNVEDTACLLGIMMGRDENDSTTVSKNLNLALNYSSSSVKGLKIGIPAEYNCQGLSDEIRSAWNDIAKVLYQGGASIVPVSMPHTKYSIVCYSILNQCEVASNMARYDGIEFGLRSKEKGNRKNSYVTTRYSGFNEVVRSRIIAGNFFLLSSNSNKYYEKALKVRRLIADDFNNAWRKGINILLTPTTLTDAPKYSEYIKKDEREQSAIQDYCTQPANMAGCPAISIPIELSKKGFPISLQLMAPKFEEKTLLGCALYIENAVNFKNMNEQ
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, Glu-AdT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YCX1_CALFG
Sequence: MRQKIFFLKRFDSELLYVQGSILKSFQRFSLTLSVSTNNSKYLDFFRTGPSQIATIRSTSFYTISETQGLNRMDM
What are the official names of this protein?
Uncharacterized 8.8 kDa protein in rps12-tRNA-Val intergenic region.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ADH1_EUPLT
Sequence: MNGCCSQDPTSKRLEGKVAVITGGASGIGACTVKLFVKHGAKVVIADVQDELGHSLCKEIGSEDVVTYVHCDVSSDSDVKNVVDSAVSKYGKLDIMFSNAGVSGGLDPRILATENDEFKKVFEVNVFGGFLAAKHAARVMIPEKKGCILFTSSNSAAIAIPGPHSYVVSKHALNGLMKNLSAELGQHGIRVNCVSPFGVVTPMMATAFGMKDADPEVVKATIEGLLASAANLKEVTLGAEDIANAALYLASDEAKYVSGLNLVVDGGYSVTNPSFTATLQKAFAVAHV
What is the function of this protein?
Involved in the biosynthesis of macrocyclic lathyrane type diterpenoids (also called Euphorbia factors) natural products, including the cyclization route from casbene to jolkinol C, a precursor for ingenol mebutate that is used to treat actinic keratosis, a precancerous skin condition (PubMed:27506796).  Catalyzes the conversion of 4,5,8-trihydroxycasbene into jolkinol C in presence of NAD (PubMed:27506796).  Mediates also the formation of casbene dione derivative and 4-ketocasbene from 4-hydroxy-8-ketocasbene and 4-hydroxycasbene, respectively (PubMed:27506796).  Together with CYP71D445, triggers the biosynthesis of 8-ketocasbene from 8-hydroxycasbene (PubMed:27506796).
What are the official names of this protein?
Short chain aldehyde dehydrogenase 1, ElADH1, Jolkinol C synthase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: A1245_CONAA
Sequence: SQCCYQICSPC
What is the function of this protein?
Probable toxin that inhibits ion channels.
What are the official names of this protein?
Conotoxin Ama1245.
What are the subcellular locations of this protein?
Secreted.
Protein: COFC_META3
Sequence: MFSALIPVSPLNAVKTRLKDFLTPDERIELIKNMLLDVYEGISPICDKIYVVSKDKEILEFLKPYAVIPIMETENIKGLNDALNYAFNYIEEDNIIITPADIPLIKKENINNIVKECKENSVILCPSRGGGTNLMVLNRSSIKTRYEGFSFLKHIEECKENNINPIIFPSFYISIDINTVEDLGEILIHGGGTYTYNYLKKLNINAKPKHSSAGRFEVIRQNTE
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: KL40A_DANRE
Sequence: MASMSVDPVTEPRMYQQTLLQDGLCDLLDANKFVDCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEESKKREIVLKDIEPGVMGMILRYIYTSDINLTEQNVQDIFMAANMYQIPSIFSVCVSYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFICDRYLLIIRDQDFHQLGPSELAAIITCDSLNVEREESVFESLMDWVEYDTDERTKELPELLHCVRFRLMPTSYFKEKVEGHRLIRTNQELKKELQLIKDAQKGLLHRVKRSSHRKEGKSAEFESDDDDEDGLLPGILNDNPRFGMFQSDLILMINDAGTVAYDVGANECFVASSSTEIPKNHCSLVTKENQIFVVGGLRYNEENKDQPFSSYFLQFDPMSSEWLGMPSLPNPRCLFGLVEAENSIYVVGGKELKEGERALDSVMIYDRQSFKWGESDPLPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKFEWKDLAPMKTARSLFGTAVHKNKIYVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLVELGGFLYAIGGFAMMPNETTEKLEPTEMNDIWKFDEEENCWNGILREIRYAAGATVLGVRLNTLRLTKI
What is the function of this protein?
ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity).  Required for skeletal muscle development (PubMed:23746549).
What are the official names of this protein?
Kelch-like protein 40a, Kelch repeat and BTB domain-containing protein 5a.
What is the protein family that this protein belongs to?
Belongs to the KLHL40 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, myofibril, sarcomere, I band.
Protein: DEF_ECOBW
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: Y133_MYCPN
Sequence: MKGFSCSRPGYLTGLLLLAVAPILTACTRDYTTKNEFQLTTAQQAKLKPATIEYWRDGDTPEINYASEERRKEAEQKSKENAKKEDKKEEKKTEDSQDSSSASTQVRSSKHGLRIYGIDTPEKHVSSKGDSTGDEKIEAEKASNYAEKLIPKGSTVWVWSLNTYSYDREVGALFFKSNPKQTFFQSFEVAMVEAGHAIPIAGTGLNLIADPELSADDPLSVIGLQLANAANKAYNAKINIWSHDTDGYRSLTAVYKLRGADISWTRFLDEANGYSSASAGTGASLYQLWDQRQAKLAQKGS
What are the official names of this protein?
Uncharacterized lipoprotein MG186 homolog.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: NBS1_ORYSI
Sequence: MVWALTPVDTVRGAQRCYIFAAGTYKVGRKDCDVIVQTDTSISRVHAEIVVEKMVAWDPQSGAPANPSYVRVVDRSKYGTFFNKVQGTQGSRLHKDEDAMLADGDTVTFGTGSATFRLSFVPIVVFFHGKKSGRISPSLQAVMTSIGAYATRKWSDECTHVLVDESCSLTPELLDAVLAKKQIVLGDWFKVMAEKNIHTAMPSSTQYIPKLTLDGMEIQVVEIKLIESCLAGYTFILGSSEKYKFGDKLHALLESTGAKYLHVDEFCANSQDSGAGENDKDILLVPAKSPLEFSKISGLFPLSKITDVKLFAAILSGHLEATAIEPPAYIVASSNSTDETIVVDSDVEIDTATSDHTVAASKSEHHIEHISDDKKEVVAISEEDAVNLVEAKTSINLHSYQEKDEIVKPMEEDVKVIEKTATMRGFKVEGEDIPVMTKVPKDETLDSRDETCHVIYTQNLVVKSILQSARAESIETGGINFKRFRKRGAVSGNSFKDLIPYSREPYRESDYKRGTVIDFMREEKKRRQMEAIAEDLFNNAKPKKKAAAGSSIHTMLTGRR
What is the function of this protein?
Component of the MRE11-RAD50-NBN complex (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity.  The complex may be involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, and cell cycle checkpoint control.  Functions also in the very early stages of meiosis.
What are the official names of this protein?
Nibrin homolog, Nijmegen breakage syndrome 1 protein, OsNbs1.
What are the subcellular locations of this protein?
Nucleus, PML body.
Protein: MET3_CRYNB
Sequence: MANAPHGGVLKDLLVRDAALHDSLLQEARSLNDIFLTERQLCDLELILNGGFSPLEGFMNERDYTSVVETLRLAPYNGQKHGDVFPIPITLDVSQEDINTLGLKQGGRVALRDPRDDAALAILTVSDIYRPNKAIEAEKVMGADDIAHPSVAYLRNNVKEFYVGGKVQAIQAPTHFDYVPLRFTPAELRAHFHKLAWRKVVAFQTRNPMHRAHRELTVRAARQRRANVLIHPVVGLTKPGDVDHYTRVRAYQALMPSYPEGMAHLALLPLAMRMAGPREAVWHAVIRKNFGATHFIVGRDHAGPGKNSQGQDFYGPYDAQELVTQFKDELQIEMVPFQAMTYLPGSDEYQPVDEVPKGTPTADISGTELRKRLRTGASIPDWFSYTGVVKVLRESYPPRPQQGFTILLTGLHNSGKDTIARALQVTLQQQGSRSVSLLLGEELRSDLDPQIGRAITPEQKHINLERIGFVAGELTKAGAAVIAAPTAPYERSRQAFKKQVVGSGGGNYFLVHVATPLEWCEKVDRRGLYKAARAGEIKNLTGVDDVYEAPEDADLVCDLRNDTVPEIVHSIIMILESQNLV
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAP_CERSK
Sequence: MTLDLDALDRALDALPNLFRGPGGVAGVVKDGQVVASRAWGYADLTRRRPMETATRLPICSISKQFTCGVLLDTLGDTAAYDARVAEFLPQFEGPLPTLRQLCDNQSGLRDYWALTVLQGAEATQTFRREDALPLIARMKTGHFPPGTAYSYCNCNFRIVSEILESETGRALPDLYAERIFGPAGMRTAELTSDTRHPADEVVGYEGSDAVGFFPADNGIFWIGDAGISASLQDMLAYESWIDATRDDENSIYRRISVPPAYVCGTPASYGFGLSHETVAGVKVTGHGGALRGFRAQRFHAADERLSVMVIFNHEASAHAAASSLLAAALGHEAPKGARPEGWAGQWLDPESGLLLRVGEDAEGLTLRFATGPDRLTLGEDGVPRGAGVSLARDGAMLVMNRTSDNLTVRAEPLPVVTVADAGEIAGRYHARELEADLVIEARDGGAYAGFEGLLGEGPMERLHPVGPDVWIVTTRRSMDAPAPGDWTLQVRREGGAVTGLRLGCWLARRIDYARV
What is the function of this protein?
Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
What are the official names of this protein?
D-aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S12 family.
Protein: ADH_DROVI
Sequence: MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIENPTAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAKLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHKFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANQNGAIWQLDLGRLISVEWTKHWDSHI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: DNAK_LACDA
Sequence: MSKVIGIDLGTTNSAVAVLEGKEPKIITNPEGARTTPSVVAFKDGEIQVGEVAKRQAITNPNTIVSIKRHMGESDYKVKVGDKAYTPQEISAMILQYIKKFSEDYLGEPVTDAVITVPAYFNDAQRQATKDAGKIAGLNVQRIINEPTASALAYGLDKDEDDETVLVYDLGGGTFDVSVLQLGDGVFQVLSTNGDTHLGGDDFDNKIIDWLVDGFKQENGIDLSKDKMAMQRLKDAAEKAKKDLSGVSSTHISLPFISAGEAGPLHLEVDLTRAKFNELTDDLVQRTKIPFDNALRDAGLSVGDIDKVILNGGSTRIPAVQEAVKQWAGKEPDHSINPDEAVALGAAIQGGVISGDVKDIVLLDVTPLSLGIETKGGVFTKLIDRNTTIPTSKSQIFSTAVDNQPAVDIHVLQGERPMAADNKTLGRFELTDIPAAPRGVPQIQVTFDIDKNGIVNVSAKDLGTGKEQKITIQSASGLSDEEIERMKKEAEEHAEEDAKKKEEVDLRNEVDGLIFQTEKTLKEVDGKLADSDIQPVKDALEDLKKAQKDNNLDEMKEKKDALSKVAQDLAVKLYQQNSQNQQGQGGQAGPTDDGSNGANGDTVDGDFTKVDPDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PR1_SAMNI
Sequence: MAHNHWCNLFSVALVCVVALVMVQYSVAQNSPQDYVDAHNAARSAVNVGPVTWDESVAAFARQYAQSRAGDCRLVHSGDPRYGENLAFGSGFELTGRNAVDMWVAERNDYNPNTNTCAPGKVCGHYTQVVWRNSVRIGCARVRCNNGAWFITCNYSPPGNYAGQRPY
What is the function of this protein?
Probably involved in the defense reaction of plants against pathogens.
What are the official names of this protein?
Pathogenesis-related protein PR-1 type.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
Protein: RL17_BURA4
Sequence: MRHRHGLRKLNRTSSHRLAMLRNMSNSLIEHEVIKTTLPKAKELRKVVEPLITLGKKPSLANRRLAFNRLRDRDSVAKLFDVLGPRFANRPGGYLRVLKFGFRVGDNAPMALVELLDRPEVDETENVQEAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: FADA_ACIAD
Sequence: MTNLNPRDVVIVDGVRSAMGKSKNGMFRNVRADSLSAELVRALVARNQFDVNEVEDLIWGCVNQTLEQGMNIGRNIVLLADLPKTVAGQTVNRLCGSSMQAIHTAAAQIATNQGDIFIIGGVEHMGHVGMMHGIDLNPEASKHYAKASNMMGLTAEMLGRMNGIGREEQDAFGVESHRRAWAATQEGRFKNEIVGVEGHDANGFKILCDIDEVIRPDANLEAFKALRPVFDPKGGTVTAATSSALSDGASAMLLMSAERAQALGLKPRAVIRSMAVAGCDAAIMGYGPVPATQKALKRAGLSVADIQTVELNEAFAAQGLSVLKGLGLYEKQDIVNLNGGAIALGHPLGCSGARITTTLLNVMEQQDTQIGLATMCIGLGQGIATVIERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_CITK8
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHQVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKFFYVWLDAPIGYMGSFKNLCNKRGDLTSFDDYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSGFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPALYKTFTDAAAVIGEAWESREFGKAIREIMALADMANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNTELSWDAIAQPLLGHKVNAFKALYNRIDMKQVDALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTVMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAB_NICSY
Sequence: MALRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFESWVQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGALGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSAISLIAGWLHLQPKWKPSVSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGEYVRWNNFLDVLPHPQGLGPLFTGQWNLYAQNPDSSSHLFGTAQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFIFLVAGHMYRTNFGIGHSMKDLLDAHIPPGGRLGRGHKGLYDTINNSLHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLEHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTSYGFDVLLSSTSGPAFNAGRSIWLPGWLNAVNENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: NBR1_MOUSE
Sequence: MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGYHVVDEALPKNVVENQAAARTGKKPLAHYSSLVRVLGSDMKTTEEPAPEQCSSAPCDTDQPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPLLSSSPTEVSMPISEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYTHDTNHVLLKLRRPVVISSEPFFYSKYSAPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWNTDTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPTLEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSSESPDNVEGDRISSSKADDFSCEQEEAFLLAEEEIPLGEVTKQTEGTGASASQKTRRAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDMTPCMSPLPHDSPLIEKPGLGQIQEESEGAGFKAPPDSTVSAKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEGQQPLVLPGFCRKDSSLKFALPEEGPRGDEREEIVHIVEEEVVEEEEEVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGLEPTEARERLPERESQPQEQSISDILTTSQPLDTVPLVPEVAGLPAALSRSAPCGQCESSGVDSPGVDSPATMHEVPPAPDDIRGEPRGSTGLANSRQRSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPIVSEDQTTALMAHLFEMGFCDRQLNLRLLRKHNYNILQVVTELLQVNNNDWYSHRY
What is the function of this protein?
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750).  Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates.  Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity).  In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398).  In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (PubMed:31916398).  Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750).
What are the official names of this protein?
Next to BRCA1 gene 1 protein, Membrane component chromosome 17 surface marker 2 homolog, Neighbor of BRCA1 gene 1 protein.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity).
Protein: Y2723_GEOTN
Sequence: MNSRQMYETIKERLNAHPHWTFHFDAKHDTMRIEDHRTKKGVTISLPGVIAKWHEQKDEAVREIIYYVEETLKTMEETATLSGNERNIYPVIRSTSFPTETKEGVPLLHDDHTAETRIYYALDLGKTYRLIDEQMMEKEKWNRERVKEIARFNVRSLPTPVKEDRVADNVFYFVNTNDGYDASRILNDAFLAEMHTRMEGTMAIAVPHQDVLILADLRNDIGYDVLAQMTMSFFANGRVPITALSFLYENGKLEPIFILGKKRRT
What are the official names of this protein?
UPF0354 protein GTNG_2723.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: RK2_RANMC
Sequence: MAIHLYKTSTPSTRNGAVGSQVKSNPRNNLIYGQRHCGKGRNARGIITVRHRGGGHKRLYRKIDFRRNEKDISGKIVTIEYDPNRNAYICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPISMGNALPLTDMPLGTAIHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISKNCSATVGQVGNVGVNQKSLGRAGSKRWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPTTPWGYPALGRRSRKRNKYSDSLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: WBBL_MYCTO
Sequence: MTDVLPVVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVRSSLRRSRRRKLKLVEGRH
What is the function of this protein?
Involved in the biosynthesis of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the transfer of the rhamnosyl moiety from dTDP-rhamnosyl (dTDP-Rha) onto the decaprenyl-pyrophosphoryl-GlcNAc (C50-PP-GlcNAc), yielding rhamnosyl-decaprenyl-pyrophosphoryl-GlcNAc (Rha-C50-PP-GlcNAc).
What are the official names of this protein?
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase, Rhamnosyltransferase WbbL, dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: LEUD_BRUA2
Sequence: MDKFTKLTGVAAPLPIVNIDTDMIIPKDYLKTIKRTGLGKGLFAEMRFNEDGSENPDFVLNKPGYRKAQILVAGDNFGCGSSREHAPWALLDYGIRCVISTSFADIFYNNCFKNGILPIKVAQEDLDKLMDDASRGANATLTIDLETKQIHGPDGGTISFDLDDFKRHCLLNGLDDIGLTMEKAKSIDTFEAKNAEERPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: MORN1_RAT
Sequence: MAAAEDQNPASLQPLRHSPRLRPRNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVNGEITGEGYQHWAWSGNTYSGQFVLGEPQGHGIMKYKAGGHYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMVFKNGDKYEGDWVRDQRQGHGVLFCADGSTYKGQWHNDVFSGLGSLVHCSGVTYCGMFINGHPAAQAKKIVVLGPELLEVVQGSPFTLSVQLQQDDGEVAKSESGRVLKISAGVRYVQLPEYSEVSFFKMDDAHMETPIQTPFGFQCIPYPLSVSTSWGLEPGSTVESARADLLLSKKDSEPVLDSEAFHGKGDTLSILPARRHEPCCSAAYQRVDQGCAEFVDIHLGAPPPGMQPYLFLPSMLEKAGNRPKGDRSPPEVLSTAQEPLRGTNRSDGTTAEPSTAAYLGEYVLMVCDVTSPPFLGHRLPTTFKHLRILARGDIHLPHVPEDHPEALS
What are the official names of this protein?
MORN repeat-containing protein 1.
Protein: DBNL_MOUSE
Sequence: MAVNLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEELVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACANHVSTMANFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESTSFQDVGPQAPVGSVYQKTNAISEIKRVGKDNFWAKAEKEEENRRLEEKRRAEEERQRLEEERRERELQEAARREQRYQEQHRSAGAPSPSSRTGEPEQEAVSRTRQEWESAGQQAPHPREIFKQKERAMSTTSVTSSQPGKLRSPFLQKQLTQPETSYGREPTAPVSRPAAGVCEEPAPSTLSSAQTEEEPTYEVPPEQDTLYEEPPLVQQQGAGSEHIDNYMQSQGFSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
What is the function of this protein?
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis.  Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL.  Does not bind G-actin and promote actin polymerization by itself.  Required for the formation of organized podosome rosettes.  May act as a common effector of antigen receptor-signaling pathways in leukocytes.  Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
What are the official names of this protein?
Drebrin-like protein, Actin-binding protein 1, SH3 domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the ABP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Synapse. Perikaryon. Cell projection, neuron projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Cell projection, dendrite. Postsynaptic density. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes.
Protein: ILVC_DESOH
Sequence: MPTINFGGVEENVVTSEEFTLKKAREVLKNEVITVLGYGVQGPAQALNLKDNGFEVIIGQLEGDAYWEKAIADGFVPGKTLFPIEEAAKKGTIIKMLLSDAGQVAVWPKVKKCLKKGDALYFSHGFGIVYKDQTGIVPPKNVDVILVAPKGSGTNVRRNFKDGSGINSSYAVFQDATGRAEERTIALGIAIGSGYLFPTTFEKEVFSDLTGERGVLMGCLAGTMEAQYNVLRKHGHSPSEAFNETVEELTQSLIRLVAENGMDWMFANCSTTAQRGALDWAPKFRDAVAPVFDSLYRRVKNGAETRRVLKVNSAPNYLEKLRKELDTIKNSEMWQAGAAVRALRPENRKKKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NAD(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.