PharMolix/UniProtQA huggingface dataset:
Protein: MXMT1_COFCA
Sequence: MELQEVLHMNEGEGDTSYAKNASYNLALAKVKPFLEQCIRELLRANLPNINKCIKVADLGCASGPNTLLTVRDIVQSIDKVGQEEKNELERPTIQIFLNDLFQNDFNSVFKLLPSFYRKLEKENGRKIGSCLISAMPGSFYGRLFPEESMHFLHSCYSVHWLSQVPSGLVIELGIGANKGSIYSSKGCRPPVQKAYLDQFTKDFTTFLRIHSKELFSRGRMLLTCICKVDEFDEPNPLDLLDMAINDLIVEGLLEEEKLDSFNIPFFTPSAEEVKCIVEEEGSCEILYLETFKAHYDAAFSIDDDYPVTSHEQIKAEYVASLIRSVYEPILASHFGEAIMPDLFHRLAKHAAKVLHMGKGCYNNLIISLAKKPEKSDV
What is the function of this protein?
Involved in the biosynthesis of caffeine (By similarity).  Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and of paraxanthine to caffeine (By similarity).
What are the official names of this protein?
7-methylxanthine methyltransferase 1, CcMXMT1, 7-methylxanthine N-methyltransferase 1, N-methyltransferase, Theobromine synthase MXMT1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBIB_ECOLI
Sequence: MDYRKIIKEIGRGKNHARDLDRDTARGLYAHMLNGEVPDLELGGVLIALRIKGEGEAEMLGFYEAMQNHTIKLTPPAGKPMPIVIPSYNGARKQANLTPLLAILLHKLGFPVVVHGVSEDPTRVLTETIFELMGITPTLHGGQAQAKLDEHQPVFMPVGAFCPPLEKQLAMRWRMGVRNSAHTLAKLATPFAEGEALRLSSVSHPEYIGRVAKFFSDIGGRALLMHGTEGEVYANPQRCPQINLIDREGMRVLYEKQDTAGSELLPQAKDPETTAQWIERCLAGSEPIPESLKIQMACCLVATGEAATISDGLARVNQAF
What are the official names of this protein?
Uncharacterized protein YbiB.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CCR2_MOUSE
Sequence: MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
What is the function of this protein?
Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines (PubMed:8631787, PubMed:8662823, PubMed:8996246).  Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity).  Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity).  Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (PubMed:28507030).  Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (PubMed:29930553).  Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed:29993042).  Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed:29993042).  Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (PubMed:24806994, PubMed:29632244).
What are the official names of this protein?
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, JE/FIC receptor, MCP-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are reportedly distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.
Protein: LSPA_AERHH
Sequence: MNMTHHKSGLRWLWLAVLAFVLDQASKLAVVKLLPFGYPGVEITPFFNLVHVYNKGAAFSFLADQGGWQRWFFAVLAFAICGLLIHWLRKQSVAQRWSGIAYSLIIGGALGNVFDRLVLGHVVDFLDFYWQRAHWPAFNLADSFIFIGAAMIVLDGFRSEKKKDVTP
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS10_ECOBW
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ARF6_CHICK
Sequence: MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATTGDGLYEGLTWLTSNYKS
What is the function of this protein?
GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling.  May modulate vesicle budding and uncoating within the Golgi apparatus.  May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).
What are the official names of this protein?
ADP-ribosylation factor 6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, ruffle. Cleavage furrow. Midbody, Midbody ring. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body. After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. Myristoylation is required for proper localization to membranes (By similarity).
Protein: NU5C_DIGGR
Sequence: WIIPFVPLPVPMLIGVGLLLFPIXTNKLRRMWAFPSILLLSIVMIFSTNLSIQQINSNSIYQYVWSWTLDNDFSLELGCLIDPLTSIMSMLITIVGITVLIYSDNYMAHDQGYLRFFAYMSFFSTSMLGLVTSSNLIQIYIFWELVGVCSYLLIGFWFTRPLAANACQKAFVTNRVGDFGLLLGILGFYWITGSFEFRDLFEIFNNLIVNNQVNYLFVTLCAALLFAGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAEGIFLVARLLPLFIVIPYIMNFISLIGIITVLLGATLALAQKDIKRGLAYSTMSQLGYMMLALGMGSYRSALFHLITHAYSKALLFLGSGSVIHSMETIVGYSPEKSQNMVLMGGLRKYVPITKISFLLGTLSLCGIPPLACFWSKDEILNDSWLYSPIFAIIAWATAGLTAFYMFRIYLLTFEGHLNVYFQNYSGKKNTAFYSISIWGKGCSKRINKNFRLLRINNQSSSFFLKKTYRSDENLKKRNGGRPFINLIRFENKKARLYPYESDNTMLFPLLILVLFTLFVGYLGISFNQEARDLDILSKWLAPSIDLLHQKSRDLTDWYEFLKDAIFSVSIAYFGILLASLLYKPIFASFKNFDLINSFVKTGPKRSRWDKILTLLYNWSHNRAYIDVFYTTSFTGSIRGLSQLTHFFDTQVIDGITNGVGVMSFFV
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: IORF_CVHOC
Sequence: MASSSGPISPTSLEMFKPGVEELNPSKLLLLSNHQEGMLYPTILGSLELLSFKRERSLSLQKDKVCLLHQESQLLKLRGTGTDTTDVLLKQPMATSVNCCHDGIFTIWEQDRMLKTSTAPILTESTGSLATRLMSIPRLTLSIGTQVAMRLFRLGFRLARYSLRVTILKAQEGLLLIPDLLRAHPAEPLVQDRAVEPILAIEPPPLV
What is the function of this protein?
Structural protein that is not essential for the viral replication either in tissue culture or in its natural host.
What are the official names of this protein?
Protein I, Accessory protein N2, N internal ORF protein, IORF, Protein in nucleocapsid ORF.
What is the protein family that this protein belongs to?
Belongs to the coronavirus I protein family.
What are the subcellular locations of this protein?
Virion.
Protein: MTNB_ACICJ
Sequence: MTLAAGPAEAGDVLASRARELVAIGARMDARGWVPASAGNLSARCTADSIAITRSGVHKGRLEAADIIEVWLDGTPLRAGDRPSAETQLHCQVYERLPAAGAVLHGHSVAATALTLADNSPGIVLEGYEILKAFPGIATHETRIVLPVFDNDQDMRRLAAAIAPAFAAPPIGYVLRGHGIYAWGEDVERCFWRLEALEFLLSCECERRRMR
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: DRE2F_ARATH
Sequence: MEKSSSMKQWKKGPARGKGGPQNALCQYRGVRQRTWGKWVAEIREPKKRARLWLGSFATAEEAAMAYDEAALKLYGHDAYLNLPHLQRNTRPSLSNSQRFKWVPSRKFISMFPSCGMLNVNAQPSVHIIQQRLEELKKTGLLSQSYSSSSSSTESKTNTSFLDEKTSKGETDNMFEGGDQKKPEIDLTEFLQQLGILKDENEAEPSEVAECHSPPPWNEQEETGSPFRTENFSWDTLIEMPRSETTTMQFDSSNFGSYDFEDDVSFPSIWDYYGSLD
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.  Binding to the C-repeat/DRE element mediates high salinity-inducible transcription.
What are the official names of this protein?
Dehydration-responsive element-binding protein 2F, Protein DREB2F.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL32_POLAQ
Sequence: MAVQQNKKSPSKRGMHRAHDFLTAPATAVEATTGEAHLRHHISPNGYYRGRKVVKTKND
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: ISPH_SHIBS
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: LPXK_COXB1
Sequence: MLKAPRFWYQPRSLLGGILSPFSFLYQIIVRIRRGLYAVGLKKISKFPVPIVIVGNITVGGSGKTPFVIWLANELKNRGFRPGVVSRGYGGKANRFLQTVTENSDPLQVGDEAVLLMKKIDCPMVVCRDRGAAVKHLLRNFQCDVVIGDDGLQHYSLGRDLEIALLDDRHLGNGRCLPAGPLREPKSRLNTVDFVVPKQLRPNEIYQLKNPAKKIDFNELKELTVHAVAGIGNPGYFFKQLETLGANVIAHPFRDHYFYRSEDFNFDDDHLIILTEKDAIKCKQFDDERLFCFSVDAVVPDQFQNDFFRLISNIILRKQAQREGI
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: HEM1_SHEB2
Sequence: MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIAWLEEYHGLDHKDVAPCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQAFVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVSVAFAAVSMAKHIFSSISTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKADIVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNMASRKEAAEQAEVITEEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERALNKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGDLNTLGQLRSALGLDKN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: GLMU_STAAM
Sequence: MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEKQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQRRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD34_HUMAN
Sequence: MWAAGRWGPTFPSSYAGFSADCRPRSRPSSDSCSVPMTGARGQGLEVVRSPSPPLPLSCSNSTRSLLSPLGHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGFYSGNSYPEPAFYNPIPWKPIHMPPPKEAKDLSGRKSKRPVISQPHKSSSLVIHKARSNLCLGTLCRIQR
What is the function of this protein?
Involved in spermatogenesis.  Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella.
What are the official names of this protein?
Coiled-coil domain-containing protein 34, Renal carcinoma antigen NY-REN-41.
Protein: OBP1_BOMMO
Sequence: MWKLVVVLTVNLLQGALTDVYVMKDVTLGFGQALEQCREESQLTEEKMEEFFHFWNDDFKFEHRELGCAIQCMSRHFNLLTDSSRMHHENTDKFIKSFPNGEILSQKMIDMIHTCEKTFDSEPDHCWRILRVAECFKDACNKSGLAPSMELILAEFIMESEADK
What is the function of this protein?
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
What are the official names of this protein?
General odorant-binding protein 1, GOBP1.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
Protein: QUEC_METM7
Sequence: MRAICVLSGGLDSAVTSLAAKFENYDITTVTFNYGQMALNQEIKSAKKISEILNADHHVIDINFVKEFSKSGLNTGEIPEPEKEDLDDFEKSEKTMKAVWVPARNMIMFSIASGFAEGIGAEKIFSGLNKEEGVTFPDNTPEFIERFNKSLEYGTLNKVKMVAPLYELNKPEIAKLGKELEVKLDLEVLKYSYSCYRDNGEDYLHCGTCESCMRRKRAFKEAGIVDPTKYLVE
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DEF1_RICCN
Sequence: MSILPIVTAPDERLKQKSQPVLEFTDQTRKFMDDMLKTMYHEDGAGLAAVQVGVLKRILVIDIQDHDSVARPKDFYPLFIVNPEIIEKAEELVTANEGCISLPEQRIEVARPESIKIRYLDYHGKSRELKANDWLARVIQHEYDHLEGKLMIDYLSNLKRDVVLRKLKKLKNNIV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
What are the official names of this protein?
Peptide deformylase 1, PDF 1, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LUXS_BACMK
Sequence: MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAQRLMNFWLSQDKDELEKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: MNME_RHILO
Sequence: MISGDSIVALSSGRLPAGVAVLRISGPQTRFVVETIAGGMVKDRVAVLRRFKAPDGTVLDSGLVIFFPGPASFTGEDVAEFHVHGGRAVVARMLEIISGFDGVRHAEPGEFTRRAFLNGKVDLVETEALADLVNAETEAQRRFAVRNAEGVQSELYLSWRRRLIHARAMIEAEIDFADEDDVPGSVSDTVWSDVRAMIGEIDRHIAGFHAAEIIREGFEVVILGAPNAGKSSLFNALARRDAAIVTDEPGTTRDLLEVTLDLGGLRVRLTDTAGLREAPGKVEAIGIEKARAKADRADLLLLLEDILAPGVLGPLPGKAPLLRVGTKLDLLDEGSAREAAGRYDVAISVVGGTGVEALLAEIGRRAADAAGDVGDVLPSRLRHVELLGEANRHLLRAAAEDAAGQELRAEELRLAADSLGRIVGAIDVEDMLDVIFSQFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_CLONN
Sequence: MSFRFIYGRAGSGKSKFCIDDIEKRLQEDTNKQLILIVPEQFSFQAEKSVVEKVKGTGITNVKVTSFERIAYDVFNEVGGSTHKIINSSGKLMLIFNIINNLKDELKVFATAANQEGFVNNISDIITELKRYDVTATELRATLNLIEDEFLKDKINDISYIFEQFQESLHKNYIDSEDELTLLYRKIDTSKMFDGAEVWIDEFSSFTPQQYKILEKLMEKASRVNITLCMDYYRVIDGTDVFAPTKRTEEKLREILKEKDVKLDKPIILNNDDVNRFKDSSELKYLEENYFKYPYKPYDKTTDDIKIIRALNPYSEVENIAKEIAKISMESNIRYRDIAVITRDLEGYEKIVKTIFDEYEIPYFIDKKKEIDDNPLIVLITSVIEIFNKSWSYEAMFRYLKTGLSNVSKEEVDLLENYVLAYGIRGKKKWQSPWEYGNENILEKINEIRIKVSEPLIKFSSKLKGKSKADEICSAVYNFLCSIGVNETIEKWVYKFKNEGNQALAKEYSQIWNMVIELLDQVVEVFKEEELQLKDFVKILSLGFKDYKMGLIPPSLDQVLVSDVERVRTHEIKLLYIIGVNDGIFPAVSKDEGILSDSDRGSLKKIGIEIAEDTKSKAFEEQYLIYRTLTTTQKYLRICYSIADYEGKALRPSIIVSRFKSLFPKIAEESDNIAMDYEEENIDLISREIPTFNNLVSVLRREDNKVKVSPFWSDVYKWYSENPRWKETLDTVFSAISYTNAVDDISEEKIRKMYGNKLYLTVSRLEKYAQCPFGYYIKYGLKAKERKIFALTPPDLGTFMHNVIDEFSEVVDKSGFKWYEIEDKWCKDTVSEIVDRKAEESAGGIFTSSARYKYFTERLKRVLIKTILVIIEHLKRSGFQPIGHEVGFGNDEKYPPIEIELSSGEKVKLIGRIDRVDKLDMEKKDYYRIIDYKSGNKDFSLSDVYYGLQLQLLTYLDAILTNEELKDREEALPGGVLYLKIDDPIIKGKRNLSEEEIQDEIMKALKMKGLLLADEEVVKEMDRKIEGNSLIIPARINKDGSLGKSSVGTEEQFRLLREHVKKNLIKACEDMLKGDIKIRPIRSKNADACTYCLYSSICEFDTNFEDNEFKVVQEKKDEEVWELLRKEGEESWEK
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: RIMM_PSYA2
Sequence: MSSAPNASALMKIGQLKKPYGIKGWLWVFSETDDRTAIFDIKPWWMKTATGMKPLTVKAWRQQGTGVVAQFEQIPDRNVAETMNGVTLWVEQDILPEPAEDEYYWSDLVTLRVINEQDEYLGDITEMFETGAHAIMRVAATSDSLDKEERLIPWHKQTVVKVDLTEKTVLVAWPSDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_ECO27
Sequence: MTLWINGDWVTGQGALRVKRNPVSGEVLWQGNDADAAQVGQACRAARAAFPRWARLSFGDRQVRVECFAGLLESNKAELTAIIARETGKPRWESATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLFLKSGTQGDAFLARLVAVSQRLTPGTWDDEPQPFIGGLISEQAAQQVVTAWQELEAMGGRTLLAPRLLQAGTSLLTPGIIEMTGVTGVPDEEVFGPLLRVWRYDNFDEAIRMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: TENA2_MAIZE
Sequence: MDGGGVDTATTAAWMEKHRHMYERATRHPFTVSIRDGTVDMSAFKRWLSQDYLFVREFVAFIASVLLKCCKQEDSSDMEIILGGVASISDEISWFKNEATVWGVDLASVSPLKANLEYHRFLRSFTEPEISYAVAVTTFWTIETVYQDSFGFCIQDGNKTPPELLGTCQRWGSAGFRQYCQSLQSIVDRCLANAPADAVQSAEEAFVRVLELEIGFWDMSSSRS
What is the function of this protein?
Involved in thiamine salvage by hydrolyzing the thiamine breakdown product 4-amino-5-aminomethyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) (PubMed:25014715).  Has a high formylamino-HMP amidohydrolase activity (PubMed:25014715).  No activity with other thiamine degradation products such as thiamine mono- or diphosphate, oxothiamine, oxythiamine, thiamine disulfide, desthiothiamine or thiochrome as substrates (PubMed:25014715).  Does not display thiaminase II activity, as it is unable to hydrolyze thiamine (PubMed:25014715).  Is able to carry out two successive steps in the salvage of thiamine breakdown product, whereas two separate enzymes are required in Bacillus species (Probable).  May also serve a damage pre-emption function by hydrolyzing products that would otherwise do harm (Probable).
What are the official names of this protein?
Bifunctional TENA2 protein, Aminopyrimidine aminohydrolase, Formylaminopyrimidine amidohydrolase, Formylaminopyrimidine deformylase, Seed maturation protein PM36.
What is the protein family that this protein belongs to?
Belongs to the thiaminase-2 family.