PharMolix/UniProtQA huggingface dataset:
Protein: ERD22_HUMAN
Sequence: MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYITKVLKGKKLSLPA
What is the function of this protein?
Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (PubMed:1325562, PubMed:18086916, PubMed:33053334).  Binding is pH dependent, and is optimal at pH 5-5. 4 (By similarity).
What are the official names of this protein?
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Protein: SAR1_GIAIN
Sequence: MGFGDWFKSALSFLGLYKKKATIVFVGLDNAGKSTLLAMLKNSATTTVAPTQQPTSQELVMGSIRFKTFDLGGHEVARQLWEQYVTNSDGIVFLVDSADPSRFEESRRTLQELLDNHDLATTPILILSNKVDIQTAVSMETMVQSFGIQHLLTGKGGSNLRSDQRPLEVFPCSVINRFGYTDGFKWLSKYL
What is the function of this protein?
Involved in transport from the endoplasmic reticulum to the Golgi apparatus.
What are the official names of this protein?
GTP-binding protein Sar1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus.
Protein: LRL13_ARATH
Sequence: MFSPVLFRFSKPNSFLVLLFFLSYIHFLPCAQSQREPCDTLFRCGDLTAGFPFWGVARPQPCGHPSLGLHCQKQTNSTSLIISSLMYRVLEVNTTTSTLKLVRQDFSGPFCSASFSGATLTPELFELLPDYKTLSAYYLCNPSLHYPAKFICPNKGVGSIHQDDLYHNHCGGIFNITVPIGYAPEEGALNVTNLESVLKKGFEVKLSIDERPCQECKTNGGICAYHVATPVCCKTNSSSEVNCTPMMPSGSSAHAGLSKKGKIGIGFASGFLGATLIGGCLLCIFIRRRKKLATQYTNKGLSTTTPYSSNYTMSNTPTSTTISGSNHSLVPSISNLGNGSVYSGIQVFSYEELEEATENFSKELGDGGFGTVYYGTLKDGRAVAVKRLFERSLKRVEQFKNEIDILKSLKHPNLVILYGCTTRHSRELLLVYEYISNGTLAEHLHGNQAQSRPICWPARLQIAIETASALSYLHASGIIHRDVKTTNILLDSNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYRLNEKSDVYSFGVVLSELISSKEAVDITRHRHDINLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAELAFRCLQQERDVRPSMDEIVEVLRVIQKDGISDSKDVVVEIDVNGGDDVGLLKHGVPPPLSPETDKTTASSSNTTASSF
What are the official names of this protein?
LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.3, Probable receptor-like serine/threonine-protein kinase LRK10L-1.3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TRPC_CAMC1
Sequence: MILDEIIKKTKEDLKKRKADYPQEWLGRSLAYNPYVPRDVLGALRASKSEPIKIIAEIKKASPSKGMIREDFEPIKIAQEYEQYANAFSILTEPHWFKGNIEYITQVRRYASRPILRKDFIVDKYQILEALVYGADFILLIAKALTQGELKELLEYAHHLGLEVLVETHDASDVKKAVFAGANIIGINHRNLDDFTMDMGLCEKLVPLLPNGKIIVAESGLYEYEQLRELSKIGVDAFLIGEHFMRQDDIKSAVKKIKEGE
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: HN_SENDO
Sequence: MDGDRSKRDSYWSTSPGGSTTKLVSDSERSGKVDTWLLILAFTQWALSIATVIICIVIAARQGYSMERYSMTVEALNTSNKEVKESLTSLIRQEVITRAANIQSSVQTGIPVLLNKNSRDVIRLIEKSCNRQELTQLCDSTIAVHHAEGIAPLEPHSFWRCPAGEPYLSSDPEVSLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPIVDERTDYSSDGIEDLVLDILDLKGRTKSHRYSNSEIDLDHPFSALYPSVGSGIATEGSLIFLGYGGLTTPLQGDTKCRIQGCQQVSQDTCNEALKITWLGGKQVVSVLIQVNDYLSERPRIRVTTIPITQNYLGAEGRLLKLGDQVYIYTRSSGWHSQLQIGVLDVSHPLTISWTPHEALSRPGNEDCNWYNTCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIMYSNTTNIINMLRIKDVQLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTSIPKLCKAES
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase, HN protein, Protein HANA.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=Folded in the endoplasmic reticulum.
Protein: SECA2_GEOKA
Sequence: MFAKVKQLFDESAREVQRLAKLAAQINEWEPTISSLSDEQLRQKTVVFKERLERGETLDDIKIEAFAVVREAARRVLGLRHYDVQLMGGLAMHEGNIAEMQTGEGKTLAATLPSYLHALLGKGVHIITANEYLARRDCEQMGRVFRFLGLTVGLNVSQMTASEKKEAYAADITYGTGTEFGFDYLRDNMVYRLEDKVQRPLYYAIIDEIDSILIDEARTPLIIANKSGIGAELFPIMARIVRTFEEGKEYERSLETKQIFLTEEGAQKIERAFGIDNLYDWEHHVLLHHAMQSLRAWFIMRRDVDYIVKNGKVMIVDPFTGRVMEGRSFSDGLHQAIEAKEGVEITEENDIQATITIQNYFRMYEKLAGMTGSATPSKEEFWQTYRLRVITIPTNQPSRRTDWDDLVYQTYEAKVRKIIDEVKKMNAIGRPVLIGTTSVAQSEQLSAAFSKAGIPHHLLNAKTEEEEARIIATAGQKGQVMIATNMAGRGTDILLGEGVKELGGLHIIGTERHESHRIDMQLRGRAGRQGDPGSSQFIISLDDDLFRLYDQDELKKWKSKVETDETGRIVSPDPIKFVQKVQTTIENAHYSARLHLLKLDTVIDQQSKVIYHMRDRVLALKQAEVLSELLRHIHRHITQTIDRYCPENVFFEEWNIEGLHNELRRAFFRFAYPIDDLRHKQKEEIAQLVWDEYKSLEAALADLPCDEEQTMRLKHLMVETIDAHWIRHLNQLNLLKEGIHLRSYGQEDPYRAFEMDAYREFVALQQAIDAGICTTAMNYLKSQFVIDDEAAAAANKP
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 2.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: RL10_NOSS1
Sequence: MGRTLENKKEIVADLKETLGESTLALVIEYQGLTVAEITDLRKRLRPSGTVCKVTKNTLMGIAIQDDEKWQPLSELLKGSSAFLLVKEDFSSAIKAYQEFQKVTKKTELRGGVMEGRLLKEPDVKALGDLPSKEQLMGQIAGAINALATKIAVGINEVPGGLARALQAVADKENGGDDSAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SPEE_ECOUT
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTNQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LHPL4_HUMAN
Sequence: MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCPVAHSQGP
What is the function of this protein?
Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites.  Acts in concert with NLGN2 to recruit or stabilize GABAARs.
What are the official names of this protein?
LHFPL tetraspan subfamily member 4 protein, GABAA receptor regulatory Lhfpl4, Lipoma HMGIC fusion partner-like 4 protein.
What is the protein family that this protein belongs to?
Belongs to the LHFP family.
What are the subcellular locations of this protein?
Cell projection, dendrite. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Specifically localizes to inhibitory postsynaptic sites (By similarity). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (By similarity).
Protein: UROM_MOUSE
Sequence: MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDGLVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYETLTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSSEGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEECRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTENGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ
What is the function of this protein?
In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (PubMed:14871399, PubMed:15327412).  Protects against urinary tract infections by binding to type 1 fimbriated E. coli (PubMed:11134021).  Binds to the bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E. coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (By similarity).  Also promotes aggregation of other bacteria including K. pneumoniae, P. aeruginosa and S. mitis and so may also protect against other uropathogens (By similarity).
What are the official names of this protein?
Uromodulin, Tamm-Horsfall urinary glycoprotein, THP.
What are the subcellular locations of this protein?
[Uromodulin, secreted form]: Secreted. Note=Detected in urine. SUBCELLULAR LOCATION: Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalizes with NPHP1 and KIF3A.
Protein: DEF_NEIMA
Sequence: MALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVVMDLTEDRSEPRVFINPVIVEKDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFTLEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLKKRQKHTI
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ACYP_OCEIH
Sequence: MRHIKVNVKGQVQGVGFRYFTQQAATENAIVGWVRNEDDGSVLIEAQGEDKNVDAFLNEVEKGPTKFARVQDMEVKELAEDTELTKFEVKY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PIMT_ROSDO
Sequence: MSEAERKMQFLYALRSKGVTDKRVLSAMENIDRGPFIRGIFAERAYEDMPLPIACGQTISQPSVVGLMTQALKISPRDKVLEVGTGSGYQAAILSRLARRVYTLDRHSRLVREARTLFEEMNLTNITAITADGSYGLADQAPFDRILVTAAAEDPPSTLMEQLKVGGIMVIPVGQSDAVQHLIVVHKTEDGLEYDELRQVRFVPLLEGLGKDG
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_LEPCP
Sequence: MELNSIKPGSGSKHAKRRVGRGIGSGLGKTAGRGHKGQKSRAGGYHKVGFEGGQMPLQRRLPKRGFKSHLLKFNAEITLGQLQVLAVDEVDLLLLKQIGLVGELAKVVKVVKSGELTRAVVLKGIGATAGAKAAIEAAGGSLAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GMHA_THEYD
Sequence: MEIEDKIRKAYEESVRVKEQFFRENISLIKEVAEIIAKSLNEGGKILIFGNGGSATDASHIAAEFVNRFKRERPGLPAIALNTDMAVLTAIANDYDYSEIFAKQVKALGESGDIVIGISTSGSSRNVIKAIEVAKKRGLKSIAFTSKKGEKLISKVDYAFAVPSEDTPRIQETHITLGHILCELVEDILFEIPAAKKKLKQ
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_GRAFK
Sequence: MGQKTNPIGNRLGIIRGWESNWYGGNDYGDKLAEDDKIRKYIHARLSKASVSRVIIERTLKLVTVTITTARPGIIIGKGGQEVDKLKEELKKITDKEVQINIFEIKRPELDAHLVGASVARQIENRISYRRAIKMAIAAAMRMNAEGIKIEISGRLNGAEMARSESYKDGRIPLSTFRADIDYALVEAHTTYGRLGVKVWIMKGEVYGKRELSPLVGLAKNQGKKSGAGRGGNKSRRRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL16_SALTO
Sequence: MLMPRKPPKGFRKPHHPDRSGASKGGNRVVFGEFGIQALEPAYVTNRQIESARIAMTRHIKRGGKVWITIFPDQALTKKPAETRMGSGKGSPEWWVANVKPGRVLFEMSFPNEQIAREAMRRAIHKLPMKCRIVTREVGES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ASTD_VIBC3
Sequence: MTHWIAGEWVAGTGEKLESHTPYSHELLWQGYSASGEQVDAAVKAARRAFLDWKKRPFAEREQKVLAFAELVKANSEQIAQVIAKETGKPLWETRTEAASIAGKIAISIRAYHERTGETVREAAGNQLVLRHRPLGVMAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSEQTPWTGEVLMQLWQQAGLPAGVINLVQGSKETGIALAQSRGIDGLLFTGSANTGHLLHRQFAGQPDKMLALEMGGNNPMVISEHYGDLDATVYTIIQSAFISSGQRCTCVRRLYVPQGTKGDALLDKLVSVTAKLRIDQPFAEPAPFMGPLVSEAAAQAILKAQADLQALGGKSLLEARALHAAFITPAIIDVTAIERLPDDEYFGPLLQVVRYQTLAQAVELANDTRFGLSAGLVSTDDGEWDYFVEHIRAGIVNRNRQLTGASGDAPFGGPGASGNLRPSAFYAADYCAYPMASMEGDTTLLPATLSPGVEL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: RAVA_YERPG
Sequence: MAQSSQLAERISRLSHALESGLYERQEAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFRHARAFEYLMTRFSTPEEVFGPLSIQALKEEGRYQRMTGGYLPEAEIVFLDEIWKAGPAILNTLLTAINERRFRNGDREDSIPMRLLVTASNELPDADSSLEALYDRMLIRLWLDRVQEKQNFRSLLISRQNENHNPVAENLSITDEEFHQWQPLIDKITLPDHCFELIFQLRQRLSALEHTPYVSDRRWKKALRLLQASAFFSGRDEITPIDLILLKDCLWHDLNSFKLLQQQLEQLLTEQGYQQQNLLMKLQDINSKWLQHQQQQSDHQALTVVKQSGMFSRKAQYALPDNLTDSTLTLLLQKPLNLHDIQVNHLQVDKEALAQWLNKGGALRAKLNGVGYAQSIDAEIDDQLHIIILDVSRQPSTLSLPGATTTSVPPELLLALTKLESTLAEQRRLFSQHQPCLFTPSSWLAKIEASLLQVVEQLQFQQIQFQQRKFQQQKHSGH
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_UREP2
Sequence: MAKRDQLTGKGPLSGNTRSHAMNHSKRRWNVNLQKATIKTENGSQRVLVSAKTLKTLKKHNLLA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CYB_ICTST
Sequence: MTNIRKTHPLTKIINNSFIDLPAPSNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFLHVGRGLYYGSYMFPETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAIHLLFLHETGSNNPSGIPSNSDKIPFHPYYTIKDILGALFLIITLMTLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAIIPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEYPFITIGQLASILYFTILLVLMPIISIAENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MX1B_MOUSE
Sequence: MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRGQQDIQEQLSLTEAFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQINSSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSEGDSRLFTKLRNEFLAWDDHIEEYFKKDSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAVNMLRRVTKMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEKTKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD
What is the function of this protein?
Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV).  Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function.
What are the official names of this protein?
Interferon-induced GTP-binding protein Mx1, Influenza resistance protein, Myxoma resistance protein 1, Myxovirus resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region.
Protein: RUVB_BURO0
Sequence: MIETDKLATEQRIIAATPASSHEEVFERALRPRQLDDYVGQEKVRGQLEIFIEAAKRRSEPLDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERAGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYDAEQLSRIVRRSASLLNAQIDPNGALEIAKRARGTPRIANRLLRRVRDFAEVKADGQITAAVADAALAMLDVDPVGFDLMDRKLLEAILYKFDGGPVGIDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRVATLLTYRHFGLSVPDARRTERDEWDTPDGK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CYB5R_DROVI
Sequence: MVIETWKKSGIATKFPTYRNSAPVTVHSWQKGKRQDVEAEGLWRIKDGIYDFTEFIDKHPGGTFWIRETKGTDITEAFEAHHLTTAPEKMIAKYKVRDAYQRIYTLTLHEDGFYKTLKERVREKLKTIDKRPKRKSDVSDDL
What is the function of this protein?
May play a role in muscle cell metabolism.
What are the official names of this protein?
Cytochrome b5-related protein.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family.
Protein: RRF_CAMHC
Sequence: MLNSVYDAQKSDCNKALNALKRDFSTLRTGKVSVKILENIFVDYYDNQTPLNQVATVLATDATTISVTPWEKSMLKGIESAIAAANIGVNPTNDGESVKLFFPPMTTEQRKENAKKAKAMGEKAKVSIRNIRKDANDGVKKLEKDKSISEDEAKKAYDEVQKITDNFIEKIDEAVKNKEEELLKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_BACC1
Sequence: MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAESLILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMHRDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLXNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGKTVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.