PharMolix/UniProtQA huggingface dataset:
Protein: SWS_DROER
Sequence: MDVLEMLRASASGSYNTIFSEAWCQYVSKQITATMYMYCALGMMGVLFLAWFMYFKRMARLRLRDEIARSISAVTNSSGDLRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQTSQSSRQTPNGPPMGISHPLNLMQSTASGTGSGSGSGVSVTVTRPPPSPSRHSREEHTLSDPNPNPDGSVHGTSNLFTEVHGDAPNADLFHQQQQSVGNLSTRRSSITQMTPDGSHSCPPAPGVTTSIDMRLVQSSAVESLRKELGLSEEDAHIIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSNSRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEANPVTHKYSTVALVPITDEVPLTPFTYELYHSLCAIGPVLRLTSDVVRKQLGPNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEATNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFENMAKAGRLGRFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCRLPETYAVNTADLFSEDEDCDGYISEPTTLNTDRRRIQVPRAGNSLSFSETEMDSDVELDLKLERKTDKSTQSSPPTSSRTSMRGKEEARHMDNWHWGAKHKNETGSGATEGIHTSTEQEQEHQQQQQQDQGVRAEQLVYKDEDKENRSSANNETKN
What is the function of this protein?
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho).  This deacylation occurs at both sn-2 and sn-1 positions of PtdCho.  Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.  Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain.  Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).
What are the official names of this protein?
Neuropathy target esterase sws, Swiss cheese.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Sws tethers Pka-C3 to the membrane.
Protein: RWA3_ARATH
Sequence: MADSQPITPGQVSFLLGVIPVFIAWIYSEFLEYKRSSLHSKVHSDNNLVELGEVKNKEDEGVVLLEGGLPRSVSTKFYNSPIKTNLIRFLTLEDSFLIENRATLRAMAEFGAILFYFYISDRTSLLGESKKNYNRDLFLFLYCLLIIVSAMTSLKKHNDKSPITGKSILYLNRHQTEEWKGWMQVLFLMYHYFAAAEIYNAIRVFIAAYVWMTGFGNFSYYYIRKDFSLARFTQMMWRLNLFVAFSCIILNNDYMLYYICPMHTLFTLMVYGALGIFSRYNEIPSVMALKIASCFLVVIVMWEIPGVFEIFWSPLTFLLGYTDPAKPELPLLHEWHFRSGLDRYIWIIGMIYAYFHPTVERWMEKLEECDAKRKMSIKTSIIAISSFVGYLWYEYIYKLDKVTYNKYHPYTSWIPITVYICLRNSTQQLRNFSMTLFAWLGKITLETYISQFHIWLRSNVPNGQPKWLLCIIPEYPMLNFMLVTAIYVLVSHRLFELTNTLKSVFIPTKDDKRLLHNVLAGAAISFCLYLTSLILLQIPH
What is the function of this protein?
Probable O-acetyltransferase involved in the acetylation of xylan during secondary wall biosynthesis.
What are the official names of this protein?
Protein REDUCED WALL ACETYLATION 3.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. CASD1 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: MET15_HUMAN
Sequence: MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSDHENTEEVSMRRAPLMWELIHKKVLSPQDQDVQDNPRGRSAKLRAAIKL
What is the function of this protein?
N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392).  Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392).
What are the official names of this protein?
12S rRNA N4-methylcytidine (m4C) methyltransferase, 12S rRNA m4C methyltransferase, Methyltransferase 5 domain-containing protein 1, Methyltransferase-like protein 15.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
Protein: HVRA_RHOCA
Sequence: MDIDALSLNELKALRSKVDRAIVTYEERKKKEAFAELDEIARKMGYPLAEILTMVETKPRKTVAAKYANPANPSETWTGRGRKPKWVEAALASGKSLEDLTI
What is the function of this protein?
A dim-light trans-acting activator of Puf and Puh expression, that has no effect on the expression of the Puc operon.  Responsible for regulating light-harvesting-I and reaction center structural gene expression differentially from that of light-harvesting-II expression in response to alterations in light.  Proper light regulation of light-harvesting and reaction center polypeptide synthesis is an important physiological trait that enables cells to adapt to ever-changing environmental conditions of light intensity.
What are the official names of this protein?
Trans-acting regulatory protein HvrA.
What is the protein family that this protein belongs to?
Belongs to the histone-like protein H-NS family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MSRP_SALAR
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLLSWFKGNDRPKAPVGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPYTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLTQAQPTSHAKYVAFETLYAPDDMPGQKDRFVGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYASEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: RR18_LEMMI
Sequence: MDKSKQPFHKTKRSFRRRLPPIGSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSLLPFLNNEKQFERTESIPRATGPRTRNK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TTC34_HUMAN
Sequence: MLQRSPRAGPSRAQGRREAAETGGPTTQEGVACGVHQLATLLMELDSEDEASRLLAADALYRLGRLEETHKALLVALSRRPQAAPVLARLALLQLRRGFFYDANQLVKKLVQSGDTACLQPTLDVFCHEDRQLLQGHCHARALAILRARPGGADGRVHTKEAIAYLSLAIFAAGSQASESLLARARCYGFLGQKKTAMFDFNTVLRAEPGNVQALCGRALVHLALDQLQEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQLPDTGAPLEDKDTQGLLAVGEALIKIDSGQPHWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSLAEVDAPDLSCLLHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALGDGDLPRRAEDFCRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHRGLKRLKARIRREASSGCWLQ
What are the official names of this protein?
Tetratricopeptide repeat protein 34, TPR repeat protein 34.
Protein: ERKA_DROME
Sequence: MEEFNSSGSVVNGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKERQPDNAP
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate proliferation, differentiation and effect cell fate decisions in various tissues (PubMed:8157002, PubMed:19965758, PubMed:22140578, PubMed:27552662).  Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways (PubMed:8157002).  Required for embryonic epithelial tissue repair (PubMed:22140578).  During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).
What are the official names of this protein?
Mitogen-activated protein kinase ERK-A, Extracellular-regulated kinase A, Protein rolled.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NUOI_LEPIC
Sequence: MGTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYSTRFRGMHTMKRDEQGRERCTSCFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEIDLLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKERMMQLVGGPIIGERQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WAG31_MYCTO
Sequence: MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTRLIEENSDLRQRINELDQELAAGGGAGVTPQATQAIPAYEPEPGKPAPAAVSAGMNEEQALKAARVLSLAQDTADRLTNTAKAESDKMLADARANAEQILGEARHTADATVAEARQRADAMLADAQSRSEAQLRQAQEKADALQADAERKHSEIMGTINQQRAVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSNADAGGFDQFNRGKN
What is the function of this protein?
Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles.
What are the official names of this protein?
Cell wall synthesis protein Wag31, Antigen 84.
What is the protein family that this protein belongs to?
Belongs to the DivIVA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the cell poles.
Protein: PPK5_ERGCA
Sequence: SASSGESSGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, ErgCa-Capa-PK, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DER_OCEIH
Sequence: MRKSVVAIVGRPNVGKSTIFNRLVGERISIVEDIPGVTRDRIYANAEWLNHTFNIIDTGGIELGDEPLLVQMRQQAEIAIDEADVIVFLLNGKEGITSADDEVAKLLFKSNKPVVVGVNKMDNPQMHETIYEYYSLGFGQPFPISGTHGLGLGDLLDEVVGHFPNESEEEKDEDTIYFSLIGRPNVGKSSLVNALLNEDRVIVSEIEGTTRDAIDTKLHRDDQDFVIIDTAGMRKRGKVYESTEKYSVLRALRAIERSDVVLVLIDAETGIREQDKRIAGYAHDAGRAIVIVVNKWDTVDSNEKAMKEFEKNIRAHFQYLDYAPVVFLSAKTKKRMHTLVPAIKLASESHTKRIPTNVLNDVIMDAIAMNPTPTLKGKRLKVLYATQVAVQPPSFVVFVNDPELMHFSYERFLENKIRDAFGFVGTPIKLFARRRQ
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: MURG_SACEN
Sequence: MSWQQAAGYGAGDAMARRAPSVVVAGGGTAGHIEPALALADAVRRLRPDARVTALGTERGLENRLVPARGYPLELVPPVPMPRKPTPELLKLPLKVRESVKRTREVLDRVGADVVVGFGGYVSLPAYLAARGKTPIVVHEANARAGLANKVGAKFAERVLSATPDSGLAGARTIGIPLRESITTLDRAALRAQARAHFGLHPHAPTILVFGGSQGARTLNTAFSGAADALGRAGVGVLHAHGPKNTLAVQQVPGAPVYNAVPYLERMDLAYAAADLVVCRSGAMTVAEVSAVGLPAVFVPLPHGNGEQALNAQPVVSAGGARLVPDEQMTPQRVVEELLPLALDAQRLQEMSRATLSTGHREADRVLAQIVLEVAGR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ECHD3_DANRE
Sequence: MLLRGFSELLKCRGVMMKMRMKMSGDSSSLTLTEQQGGIRRIILNNPRKRNALSLQMLESLRENILTDADNPELHVIIISAVGPVFSSGHDLQELSSAEGSDLPRRVFHSCSELMMLIQDLPVPVIAMVNGVATAAGCQLVASCDVAVASEKSTFATPGVNVGLFCSTPAVAIGRTVPRKIAMQMLLTGRPLSAQQALQHGLLSAVFSEERLEDETLAIARRVCESSRPVVSLGKQIFNTQMSQSRDAAYSTAGAAMLDNLRLRDGQEGIRAFLEKRKPVWSNTDDCIH
What is the function of this protein?
May play a role in fatty acid biosynthesis and insulin sensitivity.
What are the official names of this protein?
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METN1_BACLD
Sequence: MITFEGVEKVYESGGQKVHALNGIDLHVDKGEIYGVIGFSGAGKSTLIRCVNFLEKPTAGKVFVGGRDLMSLSKAEIRTVKRKIGMVFQHFNLLNSKTIFANVAEPLALVKTPKADIKKKVTELLRFVGLEDKARDYPDQLSGGQKQRVGIARALATNPEVLLCDEATSALDPQTTGDILKLLKRVNEQYNITILLITHEMNVAKEICDKVAVIEKGRIIESGSVFDVFSAPETETAKSFVKSAIDHEIPESIQKLNLKHLYQLQFVGESSGKPFLSQVSKRYDVEVNILHGTITELQGIPFGSMTVELQGEDGEIGRALEYIRRENIRIREV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CH10_DESOH
Sequence: MKFRPLHDRILVKRVEEETKTKGGIIIPDTAKEKPIEGKVMAVGNGRLGEDGKLIPLEVKKGDRVLFGKYGGTEVKMDGQEYLIMREDDILGILE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCPG_RAT
Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMVSTLKKISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPY_RABIT
Sequence: YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY
What is the function of this protein?
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
What are the official names of this protein?
Neuropeptide Y, NPY.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Protein: HOA2_CUPMC
Sequence: MTDKKLYISDVTLRDGSHAIRHQYSVPQVRAIARALDAAGVDSIEVAHGDGLAGSSFNYGFGAHTDVEWIAAVAESVQRAAVATLLLPGIGTVHDLREAYAAGARVVRVATHCTEADTARQHIETARSMGMNVAGFLMMSHMIPPDRLAGQAKLMESYGAHCVYVVDSGGALTMDGVRARFRAFKDVLDPKTETGMHAHHNLSLGVANSIVAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAERMGWHHGCDLYQLMDAADDIVRPLQDRPVRVDRETLALGYAGVYSSFLRHAESAAGKYGLKTVDILVELGRRRMVGGQEDMIVDVALDLQRSGGAKSREAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: SYE_IGNH4
Sequence: MDVRELALKHALRNAYLHGGKAQLKPVVTAVLAESPELRPKVKEIIPIIKEVVEEVNRMSLEEQERILKERFPEALEERKKETRKGLPPLPNAERGKVKTRFAPNPDFYMTLGNARPAIISYEYAKAYEGRFVLRFEDTDPRTKRPLPEAYEAIKEDLSWLGIGWDEEYYQSQRMEVYYGLLRELVRRGGAYVCTCPPEEWRKLRDEGKPCPHRDLPPEEQEELLDQVLEGKFGEGEAVVRVKTDLRHPDPSVRDWVAFRIIDTSKHPHPLTGDKYVLWPTYNFAAGVDDYLMGITHVLRAREHRQNTVKQEFLYKHLGWTMPTVIHFGRLKLEGFVLSKSKMREAGFKGDDPRAATIRGLRRRGFAPEAIREVMLSVGIKSSDASISFANLAAENKKVIDKKAYRVMAVEDPAPAKLLAPEPLEAELPWHPTEGLGSRKYSVEPGEVVYLERADLRRAKRRGGLRLMELANFKYKGFDEDEGVYLLEFESKELDKEKGYDIVQWVKDPKGAIVWRPGERKSFALVEPEALKLEGWVQLIRKGYAKVDGVEEDTLNLIYLHE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE4_HPV35
Sequence: MADPAAAQNYPLLKLLHSYTPTTPPRPIPKPAPWAPQKPRRQITNDFEGVPSSPTTPPSECDSVPWTVLTEGSTLHLTAQTKTGVVVVVQLHL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: VG22_BPMD2
Sequence: MGAMPRVQSVVAPILREDPRLAGVTIVTWVPDIDFREFPMINIRRIGGIRNANAPKLHSLPVVEMSAYSTDGLIECEELYETALEVLYDAVKNGTQTPAGYLSSIFETMGATQFSSLYQDSWRIQGLIRLGVRTPRSTT
What are the official names of this protein?
Gene 22 protein, Gp22.
Protein: LLDD_KLEP3
Sequence: MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSLETTLFNEKLAMPTALAPVGLCGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAALRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGQPTGLEDYIGWLANNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDITILADSGIRNGLDVVRMIALGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMTLTGAKTIREISRDSLVQNAEALQTFDALKQNNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RM39_YEAST
Sequence: MVKVKSKNSVIKLLSTAASGYSRYISIKKGAPLVTQVRYDPVVKRHVLFKEAKKRKVAERKPLDFLRTAK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein L39, mitochondrial, Mitochondrial large ribosomal subunit protein bL33m, YmL39.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PAP3_ARATH
Sequence: MATLFTVARPSSLLYVSSINPSKTFSPSISLKLNSLSFSFGYRPKPLRFSKIRSSLPSESESESDLDASAVTDEWGEKPGDANEPDSQPDNVTVNVITDEWGEKSGPELEESGTRFMESDPPRNEDEWGGEIGGETEADAGNGSAVSDPTWELKRCLADSVYGTELGFKAGSEVRAEVLELVNQLEALNPTPAPLENPELLDGNWVLLYTAFSELIPLLAAGSTPLLKVKSISQSIDTNNLIIDNSTTLSSPFADFSFSATASFEVRSPSRIEVSFKEGTLKPPVIKSSVDLPESVGVFGQQISLSLLKQSLNPLQDVAANISRALSGQPPLKLPFPGNRGSSWLLTTYLDKDLRISRGDGGLFVLAREGSSLLEL
What is the function of this protein?
Probably involved in light/cold stress-related jasmonate (JA) biosynthesis.
What are the official names of this protein?
Probable plastid-lipid-associated protein 3, chloroplastic, AtPap3, Fibrillin-2, Plastoglobulin 40, AtPGL40.
What is the protein family that this protein belongs to?
Belongs to the PAP/fibrillin family.
Protein: ATPD_THISH
Sequence: MSELTTLARPYAKAVFEVAQGAGDLARWSDQLGFMAAVVHDPTMKAFLDSPKLTREAAADTVIGVCEGRIDDQGKNFVRLLAENGRLTLLPEIAAIYEVMRAEAEGKVEALVVSAQPVSDAQKSAIAQSLAKRLGREVELVCEVDESLIGGAVIRAGDLVIDGSVRGRLERMAANLSR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.