PharMolix/UniProtQA huggingface dataset:
Protein: TRI27_MOUSE
Sequence: MASGSVAECLQQETTCPVCLQYFVEPMMLDCGHNICCACLARCWGAAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEQDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNRLDHLRRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSGLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, apoptosis, immune response or autophagy (PubMed:24144979).  Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation.  Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly.  Has a transcriptional repressor activity by cooperating with EPC1.  Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events.  May function in male germ cell development.  Has DNA-binding activity and preferentially bound to double-stranded DNA.  Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979).  In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation.  Alternatively, facilitates mitophagy via TBK1 activation.  Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1.  During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy.
What are the official names of this protein?
Zinc finger protein RFP, RING-type E3 ubiquitin transferase TRIM27, Ret finger protein, Tripartite motif-containing protein 27.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, PML body. Endosome. Note=Nuclear or cytoplasmic depending on the cell type. Recruited to retromer-containing endosomes via interaction with MAGEL2 (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies.
Protein: PG117_VACCC
Sequence: MDAAIRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELKRYIDNNPECTLFESLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARFAFTECGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAMKRTLLELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPPHDNIEDYLFTYVDMNNNSYYFSLQRRLEDLVPDKLWEPGFISFEDAIKRVSKIFINSIINFNDLDENNFTTVPLVIDYVTPCALCKKRSHKHPHQLSLENGAIRIYKTGNPHSCKVKIVPLDGNKLFNIAQRILDTNSVLLTERGDYIVWINNSWKFNSEEPLITKLILSIRHQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGDLFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSDNIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIAVVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLLVKWYKKYHVPIMKLYPTPEEIPDFAFYLKIGTLLVSSSVKHIPLMTDLSKKGYILYDNVVTLPLTTFQQKISKYFNSRLFGHDIESFINRHKKFANVSDEYLQYIFIEDISSP
What is the function of this protein?
Multifunctional protein required for genome uncoating and replication.  Major viral uncoating protein that is required for the release of the viral genome from incoming viral cores containing the viral DNA genome.  Possesses an ATPase activity that is required for hexamerization and uncoating.
What are the official names of this protein?
Uncoating factor OPG117.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG117 family.
Protein: RS62_ARATH
Sequence: MKFNVANPTTGCQKKLEIDDDQKLRAFFDKRLSQEVSGDALGEEFKGYVFKIMGGCDKQGFPMKQGVLTPGRVRLLLHRGTPCFRGHGRRTGERRRKSVRGCIVSPDLSVLNLVIVKKGVSDLPGLTDTEKPRMRGPKRASKIRKLFNLGKEDDVRKYVNTYRRTFTNKKGKKVSKAPKIQRLVTPLTLQRKRARIADKKKRIAKANSDAADYQKLLASRLKEQRDRRSESLAKKRSRLSSAPAKPVAA
What is the function of this protein?
Component of the 40S small ribosomal subunit (By similarity).  Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
What are the official names of this protein?
40S ribosomal protein S6-2, Protein EMBRYO DEFECTIVE 3010.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: SYK_MYCBT
Sequence: MSAADTAEDLPEQFRIRRDKRARLLAQGRDPYPVAVPRTHTLAEVRAAHPDLPIDTATEDIVGVAGRVIFARNSGKLCFATLQDGDGTQLQVMISLDKVGQAALDAWKADVDLGDIVYVHGAVISSRRGELSVLADCWRIAAKSLRPLPVAHKEMSEESRVRQRYVDLIVRPEARAVARLRIAVVRAIRTALQRRGFLEVETPVLQTLAGGAAARPFATHSNALDIDLYLRIAPELFLKRCIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQTYGTYDDSAVVTRELIQEVADEAIGTRQLPLPDGSVYDIDGEWATIQMYPSLSVALGEEITPQTTVDRLRGIADSLGLEKDPAIHDNRGFGHGKLIEELWERTVGKSLSAPTFVKDFPVQTTPLTRQHRSIPGVTEKWDLYLRGIELATGYSELSDPVVQRERFADQARAAAAGDDEAMVLDEDFLAALEYGMPPCTGTGMGIDRLLMSLTGLSIRETVLFPIVRPHSN
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_STRR6
Sequence: MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PCSK9_LAGLA
Sequence: MGTVRSRRLWWPLPLLLLLLLGPAGARAQEDDDGDYEELVLALRSEEDGLAEALQHGATATFHRCAKDPWRLPGTYVVVLKEETQRLQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALRLPHVDYIEEDSYVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFESVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLRVLNCQGKGTVSSTLIGLEFIRKNQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAMARCAPDEELLSCSSFSRSGKRRGERIEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAGTGMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRVQPDQCMGHSGASTHASCCHAPGLECKVKEHGLPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDDTCVVRSRDVGTTGNISEEAVTAVAICCRSWHLAQASQELQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: SRY_MOSCH
Sequence: MFRVLNNDVYSPAVVQQQTTLAFGKASSLCTDNRSANDQCEMGENFRESGQDHVKRPMNAFIVWSRERRRKVALENPQMQNSEISKQPGYEWKRLTDAGKRPFFEEAQRLLAIHQDKYPGYKYRPRRKAKRPQNSLPSVSSILCNQMSVETLHPFTYRDGCAKTTYSPMESQLSRLQSMTSSLLQKEHHSSWTSLGHNRVTMATHIFADFPFYQSLEPRLSCAYFPY
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: RSXA_SALAR
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLVYLRTLSFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MPV17_XENLA
Sequence: MAGLWRAYQRLLGAHPWKVQIVTAGSLVGVGDVISQQLLERKGLKGHSIERTVKMMGIGFCFVGPVVGGWYKILDRIIPGSGKPVALKKMLLDQVAFAPCFLGCFLSIASALNGLSGEQIWGKLKRDYKDALITNYYIWPAVQVANFYFIPLYHRLAVVQFVAIIWNSYLSWKANKS
What is the function of this protein?
Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (By similarity).  Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity).
What are the official names of this protein?
Protein Mpv17.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LRIG2_HUMAN
Sequence: MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESLIPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESPQLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT
What are the official names of this protein?
Leucine-rich repeats and immunoglobulin-like domains protein 2, LIG-2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: MUTS_PSYA2
Sequence: MSVKPSAQTNDTIQSTSKSVPAASDSLVIGDAIYHLADHTPMMVQYLTMKANYPQALLLYRMGDFYELFFDDAKRAAQILDITLTRRGTDKAGNTIAMAGVPFHAADSYMARLIAAGQTVVVCEQIDESATGNARNTSNTPTMGDKQKKDKSKSAAGTIMRREVVKTLTAGTITDDALIAPNHTPTVVAIDILIPKSNSKQSLQAAISQMDLAAGTLTTQTLSANHDDIEGLKTQMLTVLARFAPSECIIGEALNDSIGGIGEDWLLWLRQSLDCPIIEVAANDFHRQHASATLCQQFGVQRLDGLGSGISDAPLAQSSCAALIHYARQTQQRQVPQINQLIVEYSDDYLIIDANSQQNLELFTPVSSNGTSLLSVLNHCQTPMGRRLLVQQMKRPLRQHSRINLRLDAIACLLKTDKTSIESNQASNQALKHSSLVISLREMLNSIGDIERISSRIGLMSAKPRDLRKLADGIASSTQLTTLLTDSGVSHEQAGLLPMLMQQLPAQLPAVQSIAKLIERAIITEPPAHIRDGGMLAAGYDDEFDRLTHLHDNIQVTLDEMVERARLESQLPSLKVGFNKVSGFYFELPKMQAKNAPAHFIRRQTLKSSERFITDELKDVETEYLSAQTLALTREKQLYHELLTELSSHLAELQQLSAAIAQIDVLSNWAQLAMTYNWQCPVMSNNDENKDSSNTDNQASIDISQGRHVVVEAALNPVNAGNAGNTVNSSNNSSNNSGTTRHNSHFVANDCALGSDANPERLLLITGPNMGGKSTYMRQTALIVLLAHCGSFVPAASAHIGDIDRIFTRIGSADDLAGGKSTFMVEMIETANILNQATNQSLVLMDEVGRGTATTDGLAIAHACVNRLLEIGCLTLFATHYFELTKLAQNPKESSGSNDKLIRNVHVAASEVDGQLLLLHQIKEGAASSSFGLHVAKMAGIPTQVLNDAKRYLVDNLTIDNLGIDNLSIDNLKSNNESANDDKNDLAKSVKDKRQQTADSDIEKLNLSNIKKTQNMTDIPQQNQLFSLQDELHAIDPDSLTPKQAHDLIYHLKKIISR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TORD_ECO55
Sequence: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLAAAVNELENCIATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPADHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALWQWLPEFVVRCRQYDSFGFYAALSQLLLVLVESDHQNR
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSX_BACAN
Sequence: MKAKTLSRHLREGVKNLSRNGWMTFASVSAVTVTLLLVGVFLTAIMNMNHFATKVEQDVEIRVHIDPAAKEADQKKLEDDMSKIAKVESIKYSSKEEELKRLIKSLGDSGKTFELFEQDNPLKNVFVVKAKEPTDTATIAKKIEKMQFVSNVQYGKGQVERLFDTVKTGRNIGIVLIAGLLFTAMFLISNTIKITIYARSTEIEIMKLVGATNWFIRWPFLLEGLFLGVLGSIIPIGLILVTYNSLQGMFNEKLGGTIFELLPYSPFVFQLAGLLVLIGALIGMWGSVMSIRRFLKV
What is the function of this protein?
Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.
What are the official names of this protein?
Cell division protein FtsX.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y424_HAEIN
Sequence: MNDKRKPSFQSAGKTFQERSVGEKYREKPTQNRPHFNDKFNGNRNEKSRFPRDKQEVKETRITQLSLSRAPSNKNAEQPKVQVTIKSTGTVYKTKEKKTGALSPRAPEKIKKNRAEEMKVYGENACLALFAERPESIVRLWATVQMSHKIGEVLSYLAENKKAYHVVDSEELARVSGTEHHGGICLLVKKPRAFTLQGYLDIPRNEDCLVLLDNVNNAQNIGGVLRTCAYFGVKNIVADNVENLYSAASMRVAEGGAEYIRVLEADYIDSALMQLRKSGYQIIHVSHNKQGDPLDKVRLKNKVVFVLSESSTESLATPEDTQARLTLASPIKSGLNIAVNAGVLLAKWYFR
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase HI_0424.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: MMM1_PARBP
Sequence: MAGSTSASLQTPYFPSSTQINPVRVDHTLPLPPAQPSLSFTQGLLVGQLSVVLLIGAFIKFFIFGEAPPPPSRGLSNRTSTHPRSYSINAASTDSSPRLLREKPSTSNILRPVPSSSTNTRSILRKTYYSATPTHPTPKHGRPRLYHSSHQPESLDWFNVLIAQTIAQYRQTAYILKDSPTSSILASLSETLNNPEKKPSFIDIIKVTDISLGEEFPIFSNCRVIAVEDPNSDGGRLQALMDVDLSDDNLSLAIETSLLLNYPKPFSAILPVALAVSVVRFSGTLCISFVPGPRTSDQTMSPIPTPHDTTSEAIDDQSSDQSSPAQNPDGPKDAHANTSNTTDASSKHGIPKTSLAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQSWFEERVVEPRVQVVGLPNIWPRMGRTGLRSSQEEPEAGSGSVEIPVMTSPGTDGVSGGGGSGGGSGGGGGSMRGIDRGLSGREVGYEALRFRHAACGGHQNQSGRDGGRGGNEQFAMPGSMPDTVTET
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: ADHI_CERS4
Sequence: MRTRAAVAVEAGKPLEIMEVNLEGPKAGEVMVEIKATGICHTDEFTLSGADPEGMFPAILGHEGAGVVVEVGPGVTSVKPGDHVIPLYTPECRQCPSCLSQKTNLCTAIRGTQGQGLMPDGTSRFSMLDGTPILHYMGCSTFSNYTVLPEIAVAKVRPDAPFDKICYIGCGVTTGIGAVINTAKVEIGAKAVVFGLGGIGLNVIQGLKLAGADMIIGVDLNNAKKEWGERFGMTHFVNPSEIDGDVVAHLVNMTKTPFDQIGGADYTFDCTGNVKVMRQALEACHRGWGQSIVIGVAPAGAEIQTRPFQLVTGRVWKGSAFGGARGRTDVPKIVDWYMEGKIQIDPMITHILSLEEINKGFDLMHAGESIRSVVVF
What is the function of this protein?
Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference.  Shows little or no activity with short-chain aliphatic alcohols.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_PECAS
Sequence: MSNTDTIVAQATPPGRGGVGILRVSGQAAAEVAHAVLGKLPKPRHADYLPFRDTNGTTLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLQRILTLPNVRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGVFSTRINQLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNGVMADLDAVRTEAHQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTAIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVERIGIERAWQEIEQADRVLFMVDGTTTQATEPEQIWPEFMARLPKTLPITVVRNKADVTGETLGIADVNTHSLIRLSARTGEGVDTLRDHLKQSMGFTSNTEGGFLARRRHLQALELAAQHLIQGKEQLVSAYAGELLAEELRLAQQSLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THOC2_RHIFE
Sequence: MAAATVVLPVEWIKNWEKSGRGEFLHLCRILSENKNHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLNDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGNITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIVEAKQIVRKLTMVVLSSEKIDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYFGQLKSRKSYMIPENEFHHKDPPPRNAAASVQNGPGGGPSSSAIGSASKSDESSTEETDKSRERSQCGVKAVNKASSATLKGNSSNGNSSSNSSKTVKENDKEKGKEKEKEKKEKTPATTPEARILGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKVKDEKFKTTVPNVESKSTQEKEREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIAEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYLNHTPPSLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGGDSFKSEKMDKISSGGKKLFSLNLSSTHKSSDKHR
What is the function of this protein?
Required for efficient export of polyadenylated RNA and spliced mRNA.  Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.  TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.  Plays a role for proper neuronal development.
What are the official names of this protein?
THO complex subunit 2, Tho2.
What is the protein family that this protein belongs to?
Belongs to the THOC2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: P5CR_STAAR
Sequence: MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.