PharMolix/UniProtQA huggingface dataset:
Protein: UVRC_WOLTR
Sequence: MGYVINIQAIKKQIELSPQSCGVYQMIGDKDKVLYVGKAKNLKSRLSNYLRYENLSERTKFMLSQVIKVEVLVTENEIDALLLEARLIKSLKPPYNIIFKDGRSYPYIVISKHNYPRIAQYRGKFKKGEFHYYGPFISVAAVKQTMLSLQKTFLLRVCSDQYFASTKRPCIEYQIKRCSAPCVGKITKDDYCQSVKQTRDTLLGRNEKVKKQLSSTMEKCSKEENYELAAIYRDRLKFLEQIQMQSMDFSFEKDADFFGIARKEDLACIGVLSFRNKDNYGSTPYFVENCSDHPDDEILSTFLIKLYNSANIPPAQIYVSDFVTGKEIIEQALHNVTHKPIKALHAKSKKEHNLLKFVYDNSQRSLEQKLTDYKNNLEKFEELSKIFLLPNIPKRVEVYDNSHTSGNQQVGVMVVAGKEGFLKSEYRKFTIKGEILGDDYEMMREVLTRRFSNNTKDVVPDFLLIDGGPGHISVVQNVLNTLNINVPFACMAKGSYRNAGNERFYMPNREDFTLKNDSKVMLYLQSLRNEAHRFAITSHRKKRDKQFFVSPLSKITSIGDKRKNALMSHFGSVENISKASLAEIQNVARISKELAEVILKHVDNKE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORR_PECAS
Sequence: MTLSINALAHIAIELQMGLSNQDRFQRLINSLRQLLRCDASALLRYENQLFRPLAIDGLAPDVLGRRFRLSDHPRLEAIARAGDVVRFPADSQLPDPYDGLIPSQEDLKVHACVGLPLFANQNLIGALTVDGMDPCQFDHFSDEELRLVGAMAAAALSNALLMERLERQLPAPVRAESPAAESVEEMVGLSEPMQRLKKEVDIVAGSDLNVLIMGETGVGKELVARAIHHGSSRANHPLVYLNCAALPESVAESELFGHVKGAFTGAIHHRTGKFEMADNGTLFLDEIGELSLTLQAKLLRVLQYGDLQRVGDDSSLKVNVRVLAATNRDLRQAVLDGAFRADLFHRLSVFPLSVPPLRERSQDVALLAGFFCERSRAQLGLARLALTAEAGALLEQYDWPGNVRELEHAIYRATVLARAGQESGEVLLGPEHFNLELPSQPIHATTGSPVAIDTVPTYFISGGLREATDDYQRRIIQQTLVRHEGNWSSCARELEMDSGNLHRLAKRLGIK
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: BDNF_HUMAN
Sequence: MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2.  Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994).  Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).  Binding to NGFR and SORCS2 promotes neuronal apoptosis.  Promotes neuronal growth cone collapse (By similarity).
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF, Abrineurin.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: RED_HUMAN
Sequence: MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKAYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRDRERERERDRERERERDREREEEKKRHSYFEKPKVDDEPMDVDKGPGSTKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYPATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGIKMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKKMEADGVEVKRPKY
What is the function of this protein?
(Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles.  Not required for the production of VSV virus particles.
What are the official names of this protein?
Protein Red, Cytokine IK, IK factor, Protein RER.
What is the protein family that this protein belongs to?
Belongs to the RED family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768).
Protein: RS13_BORT9
Sequence: MARIAGIDLPNNKQLQIALTSIYGIGRARALEICRKTDILPEKRAKDLDNDEVNKLRKIIESDYVVEGKLRSELAMSIKRLMDIACYRGLRHRKGLPLRGQRTKTNARTRKGKRKTVANKKMAAK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SDK_DROME
Sequence: MLKSAASSLRRRRPKTTITATLAIEMPSQPKLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTSAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELEKFVGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRATELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYTVEMRENEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLSDFPTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPRAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWEEEIEVVSATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTWDPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNTTLRVQNLEEEVTYTFTVRAQTSVDYGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKIEQTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFYRQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQKTLEESMAMSIDERQELALELYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCYDENPDDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKPVRNYSSYTDSEPEGSAVMSLNGGQIIVNNMARSRAPLPGFSSFV
What is the function of this protein?
Participates in homotypic or heterotypic interactions in the eye during pattern formation to prevent extra cells from joining the precluster and differentiating as photoreceptor cells.
What are the official names of this protein?
Protein sidekick.
What is the protein family that this protein belongs to?
Belongs to the sidekick family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CCD69_BOVIN
Sequence: MGCGHSRLSCCKPPKKRRQRPDQPPKPEPQELGPLNGDTATTDHVCASEEAEQHQKAITRILQQHEEDKKKWAQQVEKERELELGEKLNEQRKVLEGEHVEALRVLQASYEQDKEALTHSFQEAKAALQETIDRLTAQIEAFQAKMKRAEESILSRDYKKHIQEHGSLSQFWEQELESLHFVIEMKNERIHELDKRLILMETVKEKNLLLEEKITTLQQENEDLHARGRNQMVVSRQLSEDLLLAREALEKESQSRRQLQQEKEELLYRVLGADAAPAFPLASVTPTEVSFLAT
What is the function of this protein?
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.  Required for the localization of AURKB and PLK1 to the spindle midzone.
What are the official names of this protein?
Coiled-coil domain-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the CCDC69 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.
Protein: GSH1_PSEMY
Sequence: MSDLLSRRLAQLGEPANLSLLGECLHGIERECLRVDHDGQLALTPHPQALGSALTHAQITTDYSESLLEFITGTATDPAATLAELESIHRFAYEKLGGELLWSPSMPCALPDEETIPIARYGSSNIGRLKYVYRKGLALRYGKTMQCIAGIHYNFSLPEALWQLQQRSEGNTQSTRDYQSARYIALIRNFRRYSWLLMYLFGASPALDKGFMRGRPHQLQELDASTLYLPYATSLRMSDLGYQSSAQSGLTPCYNDLASYTDSLRLAVGTPYPAYVEAGTKRGDEWLQLNTNILQIENEYYSSIRPKRVTYSGERPIQALTSRGVQYVEVRCLDINPFLPLGIDLPQARFIDAFLLFCALEDSPLLESGECGACTSNFLKVVKEGRRPGLHLQRDGRSIELKTWASELLERIHPLCELLDRSQGGNAHIEALAQQQAKVADVEMTPSAQVLAILRQGQSFTEFALQQSLRHAEYFRAEPLSAEQQQAFEQAAHDSLAEQAELEAQPKGDFDAFVAAYQASILALAV
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: MSTN1_RAT
Sequence: MSEAGTPEAPIKKKRPPVKEEDLKGARGSLSKNQEIKSKTYQVMRDYEQAGSAAPSIFSRNRTGTETVFEKPKEGPAKSVFG
What is the function of this protein?
May be involved in the development and regeneration of the musculoskeletal system.
What are the official names of this protein?
Musculoskeletal embryonic nuclear protein 1, Fracture callus protein MUSTANG, Musculoskeletal temporally activated novel gene protein.
What is the protein family that this protein belongs to?
Belongs to the MUSTANG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUSB_LYSSC
Sequence: MKRHEAREKALQVLFQLDNTDLTVEEAMGHIKGQPTNVFYEKIVTGTAEHLEEIDATLEQHLEKWSLARLPKIERTVLRLAVYELLYMPETPKRVVLNEAIELCKTFGDDSSSKFVNGVLSKFTEQE
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RECF_PSEPW
Sequence: MSLRRIMVTAVRNLHPVTLSPSPRINILYGANGSGKTSVLEAVHLLGLARSFRSTRLNPVIQYEQAACTVFGEVQLSEGGTSNLGVSRERAGDFTIRIDGQNAKSAAQLAELLPLQLINPDSFRLLEGAPKIRRQFLDWGVFHVEPRFMPAWQRLQKALRQRNSWLRHGTLDPASQAAWDRELCLASAEIDEYRRNYIKALKPVFEQTLSELVELDGLTLSYYRGWDKDRELNEVLASSLLRDQQMGHTQAGPQRADLRLRLAANNAADILSRGQQKLVVCALRIAQGHLVSQARRGHCIYLVDDLPSELDDQHRRALCRLLEELRCQVFITCVDHELLREGWQTETPVALFHVEQGRITQTHDHRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_RICCN
Sequence: MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFATGINIGISKSIVLLFTIISMIIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLLLFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVSCLSLFGISFIYGFGGSLQFEDILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASKIGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLYMLIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKTIAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALAYCGIFTSVVAAFYYLKVVKAMYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR5_YERPB
Sequence: MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFCVGVVEKSEIIDGSKVTPGDVLVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQLDIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNCGVGMVVALPAELADKAVELLTASGEKAWKIGVIAAATEGAEQVIINP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAV_CAEEL
Sequence: MSRRSTTTSTNFGLSWSLVDVISSSTAVFKVPMNGGCDLWIGCARWLRDMKVLTTDKNGTMLEFASVLRDGILLCRLANTLVPNGIDQKKIMRTNQPSPFLCCNNINYFAMFCKTYFNLEDADLFTAEDLYYMNGFQKVLKTLSFLSHTKESLSRGVDPFPDTDNNQEGTSNGSEFEDDVEIYQSLHDNIENVDPNRTIYGPITSADPEEQQSEQLYDRIVTNRKPSMNENDLQNTPTLKRNRCIRELYDTEKNYVAQALVTIIKTFYEPLKGIIPTSDYNIIFGNIEEINVLHTALLADLEYPVKVALGLSDATPPRPISLNECVPQTIGEVFIKYRDQFLAYGKYCSNLPDSRKLSNELLKTNEFISRNINELTAQGNCKFGMNDLLCVPFQRLTKYPLLLKELQKKTDLASPDRKSLEEAVEVMEDVCNYINEESRDTNAIKVIDEIEQSITDLSMPLNVKLHDYGRVNLDGEVKMAESTLTQAGKPKQRYIFLFDKVIVVCKAANKVMAAKTTGASARTNTFTYKNAYVMSELTIDKNASLDVKSGGTITRRTQYVIIMTRDRNENNEITQLTFYFKNEATRNNWMTALLLSKSNVSPTDYLRDTNHKVAFHSFRVDVKNPATCDVCDKLMKGLQYQGYKCESCNMSMHKECLGLKKCEAVRKSTHETRSSQSFNCNRPRFHIHEGDIVVANSNSTPSDLSYLQFAKGDRIEVIKMQGHNRFTGCLINNRNRTGLVHLDHVSQSRTTSMIGLSPIDSPAGSIAPRVVRNESTVLPNKLLSDGSSRSLSGPHGSRSSRNSSSSTINGSMDSVPRQQDYVNTEISEFLWYMGEMERAKAESTLKGTPNGTFLVRYSKNRKQTAISLSYKNDVKHMIIEQNSDGKVYLDEDYIFNSTVELVQYYRSNNLIEIFAALDTCLKNPYSQCKVFKAVHDYDAPSPNNEGKFLSFKTGDIVVLLDTVGEDRGWWKGQVNNKSGFFPLSYVKPYDPATEGSSSPVTPTSSSS
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase.  Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium.  Plays a role in male tail tip morphogenesis (PubMed:21408209).
What are the official names of this protein?
Protein vav-1.
Protein: DES_SOLLC
Sequence: MSSYSELSNLPIREIPGDYGFPIISAIKDRYDYFYNQGEDAWFHNKAEKYKSTVVKINMAPGPFTSNDYKLVAFLDANSFVCMFDNSLIDKTDTLGGTFKPGKEYYGGYRPVAFIDTKDPNHAALKGYILSSFAKRHNLFIPLFRNTLSDHLFNNLEKQVTEQGKADFNALLPTMTFDFIFRLLCDQKNPSDTVLGAQGPEHLRKWLFPQLIPSLSAKKLPNIIEDMLFHNFLIPFGFIKSDYNKLVDAFSKSAVSMLDEAEKLGIKREEAVQNILFLVGINMFAGLNAFFPHLFRFVGEAGASLHTQLAKEIRSVIKEEGGAITLSAINKMSLVKSVVYETLRLRPPVPLQYGKAKKEFMVQSHDASYKINKGQFVVGYQPMASRDPKIFANPDEFVPDRFMNDGEKMLKHVLWSNGRETESPAPDNKQCPGKDLVHLLGRLILVEFFIRYDTFTLEITPLFRAPNVAFNTLTKASK
What is the function of this protein?
Involved in the biosynthesis of the anti-fungal toxins colneleic acid and colnelenic acid.  Can use (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoic acid (9-HPOD) and (10E,12Z,15Z)-(9S)-9-hydroperoxyoctadeca-10,12,15-trienoic acid (9-HPOT) as substrates but has a very low activity with the corresponding 13-hydroperoxides.
What are the official names of this protein?
9-divinyl ether synthase, LeDES, Colneleate synthase, Cytochrome P450 74D1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family. 9-divinyl ether synthase subfamily.
Protein: EUMER_EUMRB
Sequence: LNLKGLIKKVASLLN
What is the function of this protein?
Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane.  Has antibacterial activities against both Gram-positive and Gram-negative strains.  Has more potent activities against the yeast C. albicans.  Shows moderate mast cell degranulation and leishmanicidal activities.  Has a very low hemolytic activity.
What are the official names of this protein?
Eumenitin-R.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Eumenitin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Assumes an amphipathic alpha-helical conformation in a lipid environment. Forms a membrane channel in the prey (By similarity).
Protein: KTHY_BACC4
Sequence: MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVEKVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDMEDISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVVQIIEDKLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL22_THEFY
Sequence: MGTRAQARFVRVTPRKARRVVDLIRGLPAEEAQAVLRFAPQAASGPVGKVLASAIANAEHNDKLDRETLVVSRAWVDEGPTLKRIRPRGFGRAFRVNKRTSHITVEVAPRDTVGAASAKRKERTR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OADC2_PSEPF
Sequence: MIERSHHDLRKVFGELLQGDTCKFAASVFDPISVRMAYDLGFDVAIQGGSVASLQVLGAPDIALLTLDEYVEQVSRVGRASQIPIIGDADHGFGNALNVMRTVTELQKAGVAALTLEDTHLPAKYDEQSHVLIEREEAAAKIYAARFARSDDALSIIARTNVAVTTLDDSIARTAAYQKAGADAICLVGVKDFQHLEALTAHLRVPIMLINYGNPALSNVEKLSAANVRIVVNGHAPYLSAIKATYEALREQSGTEGSELSLPELLSKYTLSDSYREWAKTFLKSEHDSN
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate into pyruvate.  Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
What are the official names of this protein?
Oxaloacetate decarboxylase 2.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family.
Protein: RS2_STRGG
Sequence: MAVVTMRELLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLLQSLSYIDRAYEFVKETVAHGGSIMFVGTKKQAQEAIAEQATRVGMPYVNQRWLGGMLTNFSTVYKRLQRLKELELIDFEDVAASGLTKKELLVLSREKAKLEKTLGGIREMQKVPSAVWIVDTKKEHIAVGEARKLHIPVVAILDTNCDPDEVDYKIPGNDDAIRSVTLLTRVIADAVAEGLIARSGAATGDSKPGEKAAGEPLAEWERDLLEGDKKDETAAAAEVQTSAETEKVADAEKPAEAVAEAEAEAPAADADAEQA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYP_HELPY
Sequence: MLFSKLFAPTLKEPPKDAVLKSHKHLAQAGYIYQVGSGIYNFLPLAKKVLDKIENITHKRMQEHGAQNILMSFVVLASLWEKSGRLDKYGKELLVFKDRKDNDFVLSPTLEENITEIAANFIKSYKQLPVHLYQIHTKFRDEIRPRFGLVRAREFIMKDGYSFHEDAESLDKEFLNTQSAYKEILSDLGLDFRIVEADSGAIGGSKSREFVVLTECGEDTIVVCQNCDYAANIEIAKRSKRPEPLNVPKAQLAKFPTPNTTSAQSVAEFFKTEPYFVLKALVRKVIHKDKETLACFFVRGDDNLEEVKALNALNIIGANALELREASQKDLDNVGLIAGFIGPYGLKKHVSYIIFDEDLKEGDCLIAGANEKDFHAVGVDLKGFENLVYADIVQVKESDRCPNCQGALKYHKSLEVGHIFKLGQGYAKSLKASFLDKNGKEQFFEMGCYGIGISRLLSAILEQKSDDLGCVWTKNTAPFDVVIVVSNWKDEAQKKLAFEVYERLLQKGVDALLDDRDARFGAKMRDFELIGERLALIIGKQTLESKEFECIKRANLEKQTIKDIELEEKILEMLESE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_LEPBJ
Sequence: MSLKDFIFTSESVGEGHPDKVCDQISDAILDAYLEQDPKSRVACETLATTNLVVIAGEITSKGKVDAQEIARNVIRDIGYNDITMGFDADFAVVSAHVHAQSPDISQGVTEGEGLFKEQGAGDQGLMFGFAINETPEFMPMPIYYSHELVKHLAGLRHSNKLKFLRPDAKSQVTVEYKDGKPVRVDTVVISTQHSPDVAHKQIEESLIEECIKKVIPANLLVNTKYFINPTGQFIVGGPHGDAGLTGRKIIVDTYGGYGRHGGGAFSGKDPSKVDRSAAYMGRYIAKNVVASGLADKCEVQLAYAIGVAEPVSVHVDTFGTGKISEEELVKRIRANFKLTPRGIIESLKLLEKGRKYRETASYGHFGRKGSTFTWEKTDKTVALKG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_LACLA
Sequence: MRKNRAPKREVLADPMYNSIVVTRLINRVMLDGKRGVAAQIVYGAFKQIEEATGNNPLEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLRWLVTIARNRGEHTMQDRLAKEILDAANNTGAAVKKREDTHKMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: FTSA_BORBU
Sequence: MSRNLIVGLDVGTSKICTVVAEVNLNDQLEIVGIGTSISRGVRKGVLINIEAALDSISNSIEAAELISGCDITSLSVSMSGSSVEGTNSRGVVAINSKTREINEEDVERVIEAAKAIVIPMDREILHVIPQEFIVDGIPHIKNPIDMMGIRLEGEVHIITGSSSSSQNLVRCVNRAGFAVDEVVLGSLASSYATLSKEEREMGVLFIDMGKGTTDIILYIDGSPYYTGVIPIGVNRVTLDIAQVWKVPEDVAENIKITAGIAHPSILESQMETVIIPNLGTRPPQEKSRKELSVIINSRLREIFEMMKAEILKRGLYNKINGGIVLTGGGALFPGISNLIEEVFNYPARIGLPMSINGIGEEHIDPKFSSALGLVLYKHEQQKFNKLKKVSSKVKRKNKISSKLKGWFLKEWF
What is the function of this protein?
Cell division protein that is involved in the assembly of the Z ring.  May serve as a membrane anchor for the Z ring.
What are the official names of this protein?
Cell division protein FtsA.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.