PharMolix/UniProtQA huggingface dataset:
Protein: FAK1_RAT
Sequence: MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
What is the function of this protein?
Does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.  Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription (By similarity).
What are the official names of this protein?
Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein-tyrosine kinase 2, p125FAK, pp125FAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, cilium basal body. Note=Constituent of focal adhesions. Detected at microtubules (By similarity).
Protein: TRXB_STRCL
Sequence: MSDVRNVIIIGSGPAGYTAALYTARASLQPLVFEGAVTAGGALMNTTDVENFPGFRDGIMGPDLMDNMRAQAERFGAELIPDDVVSVDLTGDIKTVTDSAGTVHRAKAVIVTTGSQHRKLGLPREDALSGRGVSWCATCDGFFFKDQDIVVVGGGDTAMEEATFLSRFAKSVTIVHRRDSLRASKAMQDRAFADPKISFAWNSEVATIHGEQKLTGLTLRDTKTGETRELAATGLFIAVGHDPRTELFKGQLDLDDEGYLKVASPSTRTNLTGVFAAGDVVDHTYRQAITAAGTGCSAALDAERYLAALADSEQIAEPAPAV
What is the function of this protein?
Component of the thioredoxin-thioredoxin reductase system which may be involved in biosynthesis of penicillins and cephalosporins and may be important in determining the thiol-disulfide redox balance.
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: RPO1N_SACSH
Sequence: MSEKNIKGIKFGILSPDEIRKMSVTAIITPDVYDEDGTPIEGSVMDPRLGVIEPGQKCPTCGNTLGNCPGHFGHIELVRPVIHVGFVKHVYEFLKATCRRCGRVKISEDEIEKYSRIYNAIKKRWPSAARRLTEYVKKTAMKAQVCPHCGEKQFKIKLEKPYNFYEERKEGVAKLTPSDIRERLEKVPESDVEILGYDPTTSRPEWMILTVLPVPPITIRPSIMIESGIRAEDDLTHKLVDIVRINERLKESIDAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPSKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSSRTVISPDPNISIDEVGVPEIIARTLTVPERITPWNIEKLRQFVINGPDKWPGANYVIRPDGRRIDLRYVKDRKELASTLAPGYVVERHLTDGDVVLFNRQPSLHRISMMAHRVRVLKGLTFRLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGGPIIGAAQDYISGAYLLTVKTTLLTKEEAQQILGVADVKIDLGEPAILAPREYYTGKQVVSAFLPKDFNFHGQANVSSGPRLCKNEDCPHDSYVVIKNGILLEGVFDKKAIGNQQPESILHWLIKEYSDEYGKWLMDNLFRVFIRFVELQGFTMRLEDVSLGDDVKKEIYNEIDRAKVEVDNLIQKYKNGELEPIPGRTLEESLENYILDTLDKLRSTAGDIASKYLDPFNFAYVMARTGARGSVLNITQMAAMLGQQSVRGERIKRGYMTRTLPHFKPYDISPEARGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRTSQSGYMQRRLINALSDLRAEYDGTVRSLYGEVIQVAYGDDGVFPMYSAHGKTVDVNRIFERVVGWKT
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms the clamp head domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1N, DNA-directed RNA polymerase subunit A'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_SULTO
Sequence: MKKLTEKEIREELNKMKGWSLKGNVIEKTFLFHDFKEAVNFLNKVQPIADSMNHHPDVCIYYNKVIVQLTTHDAGGITDLDVELAKKIDELLT
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: CCA_FRANO
Sequence: MKFYLVGGAVRDMLLGITPKDKDWVVVGATEDEMLANGFIKIAANFPVFIHPQTKQEYALARSEKKTRNGYHGFEVNFSKYITL
What is the function of this protein?
This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site.
What are the official names of this protein?
CCA tRNA nucleotidyltransferase, CCA-adding enzyme, tRNA CCA-pyrophosphorylase, tRNA adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: MFTB_MYCTU
Sequence: MWGLLTVPAPAQARRADSSEFDPDRGWRLHPQVAVRPEPFGALLYHFGTRKLSFLKNRTILAVVQTLADYPDIRSACRGAGVDDCDQDPYLHALSVLAGSNMLVPRQTT
What is the function of this protein?
Peptide chaperone involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT).  Binds MftA and MftC with high affinity, and is essential for MftC activity on MftA, likely via the formation of a ternary complex.
What are the official names of this protein?
Peptide chaperone MftB.
What is the protein family that this protein belongs to?
Belongs to the peptide chaperone MftB family.
Protein: PROB_SYNSC
Sequence: MTLWVVKIGTSLLRGETATTIDGYARCFAGAMDRGDQVVLVTSGAVGLGCQKLALTNRPDTVVALQAAAAIGQGALMGLYERAMARHGRSVAQVLLTRSDLADRRRYQNASGTLRQLLSWGVLPVINENDALSPAELRFGDNDTLSALVAAAVEAQQLILLTDVDRLYSSDPRVDANAEPISDIRHPRELDSLEQGAGDGGRWGTGGMTTKLAAARIATASGITVQLADGRDPARLEALLQGQRGGTVFHPHPEPLGNRRSWLAHVLRPEGELQLDAGACAALQHRGASLLLVGVTAVRGDFAANQPIQLLDPDGEDLGRGLCSMDSDQLRAAMNDPSPGESSPVVVHRDGLVLRSR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLD5_CHAGB
Sequence: MDIDDILREVDPTFHSIPQEKRDLQELTRAWIAERSAPELLAWPADGLFERINDNIKQQIEKVEEMTGDMDPKTNFALIVIQTELERYRYLVRSYLRARIAKIDRHTLHYLSTDDLRARLSEMELAYATRHQALLHNHYLSSFLSSFPANLQNLNDAAAGISMIETPDLESAVFIRALKDTPVEARGVDTDAYADLKESDIVILRWADAKKLVEAGTAELV
What is the function of this protein?
The GINS complex plays an essential role in the initiation of DNA replication.  Has a role in chromosome segregation (By similarity).
What are the official names of this protein?
DNA replication complex GINS protein SLD5.
What is the protein family that this protein belongs to?
Belongs to the GINS4/SLD5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GFH1_THET2
Sequence: MAREVKLTKAGYERLMQQLERERERLQEATKILQELMESSDDYDDSGLEAAKQEKARIEARIDSLEDILSRAVILEEGSGEVIGLGSVVELEDPLSGERLSVQVVSPAEANVLDTPMKISDASPMGKALLGHRVGDVLSLDTPKGKREFRVVAIHG
What is the function of this protein?
Inhibits all catalytic activities of RNA polymerase (RNAP) by partially occluding its substrate-binding site and preventing NTP binding.
What are the official names of this protein?
Transcription inhibitor protein Gfh1, Anti-cleavage anti-GreA transcription factor, Gre factor homolog 1.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: SOXR_SALTI
Sequence: MEKKSPRLKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGDAFGILPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEHGTGARLLEDD
What is the function of this protein?
Activates the transcription of the soxS gene which itself controls the superoxide response regulon.  SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide.  The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
What are the official names of this protein?
Redox-sensitive transcriptional activator SoxR.
Protein: URODH_PSEPK
Sequence: MTTTPFNRLLLTGAAGGLGKVLRERLKGYAEVLRLSDISPMAPAAGPHEEVITCDLADKAAVHTLVEGVDAIIHFGGVSTEHAFEEILGPNICGVFHVYEAARKHGVKRIIFASSNHTIGFYRQDERIDAHAPRRPDSYYGLSKCYGEDVASFYFDRYGIETVSIRIGSSFPQPQNLRMLCTWLSYDDLVQLIERGLFTPGVGHTIVYGASDNRTVWWDNRHAAHLGYVPKDSSETFRAAVEAQPAPAADDPSMVYQGGAFAVAGPFN
What is the function of this protein?
Catalyzes the oxidation of beta-D-galacturonate and beta-D-glucuronate to galactarate and D-glucarate, respectively.
What are the official names of this protein?
Uronate dehydrogenase, D-galacturonate dehydrogenase, D-glucuronate dehydrogenase, Hexuronate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: KITH_OCEIH
Sequence: MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDGTSTMARPIHDAVEILEDVDNNVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDFRGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLIDGKPASYNDPIILVGASESYEPRCRHHHEVPFRPENNFATKSWDALKS
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANT_ECOLI
Sequence: MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSAGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPIIGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid (PubMed:22167185, PubMed:23848303).  Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D-galactonononic acid (KDN) (PubMed:23848303).  Functions as a bidirectional transporter in vitro (PubMed:22167185).
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEPA_DESAP
Sequence: MPVERDRIRNFCIIAHIDHGKSTLADRLLEYTGALVGRRMQEQVLDQMDLERERGITIKLQAVRLAYRARDGRDYQLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGIEAQTLANVNLALDHNLTIIPIINKIDLASAEPDRVRRELEDVIGLDGADAVLASAKRGDGVEEILERIVRDVPPPGGDPGAPLRALIFDSHYDPYRGVVTYLRLMDGRLFPGGPVRMMATGREFEVSELGVFTPAPVTVNELRAGEVGFMAAGIKNVKDCRVGDTVTDARRPASSPLPGYRKAKPMVYCGLFPVDGAEFEKVRDALDRLSLNDASLVYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYGLDLITTAPSVVYRVTRTNGAVLDIRNPSEMPPAGEIEKMEEPFVLTSLLLPQDYIGPVMELCQDRRGVFRNMEYISTHRVLITYEMPLAEIIYDFFDRLKSATRGYASMDYDLLGYRESKLVRVDILVAGERLDALSIIVHRDRAYHRSKIIVERLRDLIPRQLFEIVIQAAIGQRVIARESIRALRKAVLEKCYGGDVTRKRKLLEKQKEGKKRMKQVGHVQIPQEAFMSVLSIGQK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DTD_ACIB3
Sequence: MRALIQRVLEAKVVVDGETTGEIQHGLLVFLGIGREDTLATGQKLIDKILKYRIFDDEQGKMGWNVSQANGGILLVSQFTLMAQTQKGLRPDFGPAMPPSDAKALYEQLVEYTRSQFENVQTGVFAADMKVHLINDGPVTFNLEVEA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_SHEPC
Sequence: MQGSVTEFLKPRLVDIEQVNSTRAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSSKEGVQEDILEILLNLKGLAVTIEGKDEAMLTLSKSGAGPVIAADITHDGDVTIVNPDHVICHLTGNNDISMRIRVERGRGYVPASARAQTEDDDRPIGRLLVDASFSPVARIAYNVEAARVEQRTDLDKLVIDMTTNGTIDPEEAIRRSATILAEQLDAFVELRDVTEPELKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLADDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: UGE1_ARATH
Sequence: MGSSVEQNILVTGGAGFIGTHTVVQLLKDGFKVSIIDNFDNSVIEAVDRVRELVGPDLSKKLDFNLGDLRNKGDIEKLFSKQRFDAVIHFAGLKAVGESVENPRRYFDNNLVGTINLYETMAKYNCKMMVFSSSATVYGQPEKIPCMEDFELKAMNPYGRTKLFLEEIARDIQKAEPEWRIILLRYFNPVGAHESGSIGEDPKGIPNNLMPYIQQVAVGRLPELNVYGHDYPTEDGSAVRDYIHVMDLADGHIAALRKLFADPKIGCTAYNLGTGQGTSVLEMVAAFEKASGKKIPIKLCPRRSGDATAVYASTEKAEKELGWKAKYGVDEMCRDQWKWANNNPWGYQNKL
What is the function of this protein?
Catalyzes the interconversion between UDP-glucose and UDP-galactose and the interconversion between UDP-arabinose and UDP-xylose (PubMed:8615692, PubMed:17496119).  Plays a role in D-galactose detoxification.
What are the official names of this protein?
Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1, UDP-D-xylose 4-epimerase, UDP-L-arabinose 4-epimerase, UDP-galactose 4-epimerase 1, UDP-glucose 4-epimerase 1, AtUGE1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_BRUAB
Sequence: MSSSSDAIKAALEKGRAAGLSATGGKNADYIPFLASVPSDLFGLAVVTADGQTFKTGDADIAFAIESISKVFTLALVMEEIGPDSVREKVGADPTGLPFNSVIALELHNGKSLSPLVNAGAIATASLVPGDTADARWNNILECQCGFAGRRLKLSNEVNQSEQTTNFHNRAIAWLLYSAGTCYSDPMEAVDIYTRQCSTLVTATDLATMGATLAAGGVNPISGKRMVSAGNVAPILVEMTMEGLYTALGDWAYTVGLPGKSGVGGGIMAVVPGELAIAAFSPPLDPAGNSVKAMAAVAAVADSLGHNLYTTRGKVSS
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: ENO_CORJK
Sequence: MALILNIDAREIIDSRGNPTVEVDVLLDDGSFGRAAVPSGASTGVHEAHELRDGGERYQGKGVLNAVKNVIEDIDEELMGVEADDQRLIDQLMRDLDGTENKSKLGANAILGVSMAVARAAAESADLPLFRYVGGPNAHVLPVPMMNILNGGAHADSGVDVQEFMIAPIGAETFSEALRVGAEVYHTLKKVIKDKGLSTGLGDEGGFAPSVDSTKAALDLIVEAIEKAGFKVGEDVALALDVASSEFFKDGKYHFEGGEHTAEEMAKVYEDLIEEYPIVSIEDPLQEDDWEGYTALTAKIGDKVQLVGDDFFVTNPQRLAKGIEEKAANALLVKVNQIGTLTETFDAVELAHRNGYRSMMSHRSGETEDTTIADLAVALNCGQIKTGAPARSERVAKYNQLLRIEEILGDAAVYAGRSAFPRFTK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: MURE_XANCP
Sequence: MSRAMALSQLLPDVALARDVQVSGLVMDSRAVRPGDAFVAIAGFGAHGLGFAAQALASGASAILFEPPAPADLPVPADAIAVPGLRARLGVLADHFHGAPSQAMRMIGVTGTNGKTSTVQLLAQALTLLGTPTGTIGTLGVGLYGAAVPTGFTTPLVLQTHAELAQLRDAGAQAVAMEVSSHALDQGRVDAVQFDVAVFTNLTRDHLDYHGDMAQYGAAKAKLFARAGLRAAVVNLDDAFGRTLFAALDPALHAIGVSSRAQAGATVQAQDLQLDHHGIQFTLHIGEAAHPVRSPLLGRFNVDNLLAVAGALHALDIAPAQIAEVLGRLQPIHGRMNRLGGAHGAPLVVVDYAHTPDALEQALTSLRSHAQDRLICVFGCGGERDTGKRPQMAAIAEVTADVAIVTDDNPRGEDGDVIVADILRGFARPDAAIVQRDRAAAIHQAISMAGADDIVLIAGKGHEPYQEVAGVRHAFDDAAVAAQALLPRTGLGVRV
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERRFI_HUMAN
Sequence: MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSAQERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
What is the function of this protein?
Negative regulator of EGFR signaling in skin morphogenesis.  Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4.  Inhibits EGFR catalytic activity by interfering with its dimerization.  Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4.  Important for normal keratinocyte proliferation and differentiation.  Plays a role in modulating the response to steroid hormones in the uterus.  Required for normal response to progesterone in the uterus and for fertility.  Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation.  Important for regulation of endometrium cell proliferation.  Important for normal prenatal and perinatal lung development (By similarity).
What are the official names of this protein?
ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein, MIG-6.
What is the protein family that this protein belongs to?
Belongs to the MIG6 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).
Protein: XNI_SHIFL
Sequence: MAVHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIMHSQPTHAVAVFDDENRSSGWRHQRLPDYKADRPPMPEELHDEMPALRAAFEQRGVPCWSASGNEADDLAATLAVKVTQAGHQATIVSTDKGYCQLLSPTLRIRDYFQKRWLDAPFIDKEFGVQPQQLPDYWGLAGISSSKVPGVAGIGPKSATQLLVEFQSLEGIYENLDAVAEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLVR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: YTGB_ECOLI
Sequence: MLILTLLRHWHVRTKSER
What are the official names of this protein?
Protein YtgB.
Protein: NOXA1_HUMAN
Sequence: MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP
What is the function of this protein?
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase.  Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction.  May also activate CYBB/gp91phox and NOX3.
What are the official names of this protein?
NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox.
What is the protein family that this protein belongs to?
Belongs to the NCF2/NOXA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Protein: 3MGH_ALKOO
Sequence: MKLERKFYDRPTLEVSKDLLGKKLVHYVKGEKLSARIVEVEAYIGAIDKAAHSYNNKITERTKIMFGPPGYAYVYLIYGMYHCMNIVTEKDGVAAAVLIRAVEPVNGIETMANYRYSKPIEDLTKKQIHNLTSGPGKLCVAMNISKINNGADLCGEEMWIEADGYHNFEIVTTKRINIDYAEEAIDFPWRFYIKDNPFISRK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: AAE5_ARATH
Sequence: MEQMKPCAANSPPLTPIGFLERAATVYGDCTSIVYGSNTVYTWRETNLRCLRVASSLSSIGIGRSDVVSVLSPNTPAMYELQFAVPMSGAILNNINTRLDARTVSVLLRHCGSKLLFVDVFSVDLAVEAISMMTTDPPILVFIADKEEEGGDADVADRTKFSYTYDDLIHRGDLDFKWIRPESEWDPVVLNYTSGTTSAPKGVVHCHRGIFVMSIDSLIDWTVPKNPVYLWTLPIFHANGWSYPWGIAAVGGTNVCLRKFDAPLIYRLIRDHGVTHMCGAPVVLNMLSATNEFQPLNRPVNILTAGAPPPAAVLLRAESIGFVISHGYGLTETAGLNVSCAWKPQWNRLPASDRARLKARQGVRTVGFTEIDVVDPESGRSVERNGETVGEIVMRGSSIMLGYLKDPVGTEKALKNGWFYTGDVGVIHSDGYLEIKDRSKDIIITGGENVSSVEVETVLYTNPAVNEVAVVARPDVFWGETPCAFVSLKSGLTQRPTEVEMIEYCRKKMPKYMVPKTVSFVDELPKTSTGKVMKFVLREIAKKMGTTRLSRM
What is the function of this protein?
May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs.
What are the official names of this protein?
Probable acyl-activating enzyme 5, peroxisomal, AMP-binding protein 5, AtAMPBP5.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: RL27_MARMS
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGQVVIPGNILVRQRGTQFHPGVGVQIGKDHTLFAVVEGQVKFEVKGKLKRRTVSVVAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.