Protein: NRPS4_GIBZE
Sequence: MAPATCCCCADSASQAMPDMEPTIFPASEIKEEIQTMISSYSSRLGHDFNQDLAKPCNMFCLAWAILLERFTGLDNVCFGFRSEHMVTAGSERTGGVASAMQVQVTADHSVQENLDENAFVSVMIPETKAETLFNTTLSICNLGNQPLCEDEARKIDVLCKLHMSVDPATMKTLLSWDSTFMTREQAETISNTYDKIFRELSSKKRTTVSAIHCCSEQDELKILSWNGSPLNNVQKCIHQAVSWQGAMRPDAEAVCSWDGSFSYAQLLSLSDRLAFHLKKLGVGAETFVPICFDKSKWTIVAMLAILKAGGIFVPLDPTQPLLRLQNLTRKVDADTILCSPQHQEMIESIASKVIPVDAQLFESLAEQRGEVDCGSWSSGAYMIFTSGTTGEPKGALIQHGALLSSALAHGPAMMMDNNTRSLHFAASTFDVSITEILTCLILGGCVCIPSEEARLNAIEEAITQLRVNWALLTPTFVKFINPDNVPSLKTLVTGGEAMTQAVIRSWSHINLINCYGPAETSVVSHVHRGMREGKNPLNIGHQVGIHCWVVDRYNHNRLMPVGAVGELVIESHTLAREYYKEPEKTSEAFIVDPEWALNQPHHSSPRRMYKTGDLVRYNYDSSFHIAGRKDAQIKFHGQRIELGEIEYHINVGINIKHGMVVLPKAGFCEGRLLAIVQLSDASGHDLVPNGRPYQLIDGPLEQVAIAKVEETKQLLTERLPSYMVPSMWLAVEFIPRLQSGKLDRKQTGKWVEDMTEETYRKLNPVAVGDPSESLTFSNGTESQLHNIWTHVLNLKPEQLGLSQSFLSVGGDSISAMQVMSECKKRGLGLTVSHIISCKSISALARHVKEIEKPMLLQETTETPFELSPIQRLYFSRSNHDQGHYNQSFLLRVSRRIDESAMRRAIEVVIRKHSMLRARFSRDDTGRWQQRVTDKVESSYRLRSIQLSSNEELSHALIDSQTCLDYANGPLLAADLLDEEGQDQRLFVVAHHLVIDLVSWRIVLQELEELLLRPELKPDMDRPLPFQTWCQMQREHASAQTPEQALPIHGIPDGDPTYWGMEDTPNIYGQMVHEGFEVGSAQTSLLLSKCHDALRTEIPDVLMAAMVYSFGQTFTDRQTPAIFAEGHGRESWDPSIDLSNVVGWFTTIYPVFADSDATSTLIDTIKMVKDGRRKVPDNGRPYFASRWLTESGEKAFARHWPLEITFNYLGQYQQLEREGALFIPVKGIAGEVSSATDGADVGSLATCISLFEVSAVITKGTLRFSFLFNQNMKHQPKIRQWIASCEQNLSLLVESLAVMSPEPTLSDFPLVSLTYDRLRLLTQEKLPEVGIEDMGRVEDIYPCSPMQSGLLVSTTKDSAAYAAYTLHQVKSRSGGAVDVTKLADAWKRMVDYHPMLRTVFVESVTLDESLFDQVLLKEVKVPLVMSELGTDEEAIKTLDKARHHDEYSQLLHVFEICKTTSGNVFCKLDISHVIMDGTSLSILFRDLSLAYAGILGPDKGPPYSEYIRSLQHQGLQHGIEYWKSYLMGIEPCHFPVLDDGEVVDTRESKCFRVEFDELAQLQRLCDDRGVTIVNAIYAAWALVLRLYTASEEVCFGYLTSARDSQIEGIEDVVGPVINMVTCRANISDSTTLGDTMTVVQNDFLNSLKHRHIPLAQVQHALKLSDVALFNTALSYRKLPPALQDAPDVMFEEVRPTYDPDEYDVSINIEAGENDMMIDLTYWSDTMSDGQATNVASAFTTALSNILHHSDKPVAQLNHLGPRHHQQISQWNNVIPEAVESCVHGLFEEQAILRPEAPAITSWDADFTYAELDTTSTKLAHYLADLGVGLEQFVLVCFDKSAFAIVAMLAVLKAGGVCVPLDPAHPDAAIRLRAEDTGASIAAVSSSMASRLSNIVDKAVVVDSNLLQNISENAILPQINPHNACFVIYTSGSTGRPKGVVLEHRGIATNAKSSGPKLGYSEESRVLQFASYTFDNSLAEIFTTLALGGCVCVPSEHERFNDLAGAISRYRVTLADITPTVACLINPLDVPTLKTLALGGEAVTHKCVDIWRDFVSLQCCYGPSECSVNSTYSGEIAQPGKATNIGRAVGSVTWVVDATDHNRLVPIGCIGELLIDGPIVSRGYLNLPEKMAQSFVAPPASLGDMCREGNLSRKLYKTGDLVRYNSDGTLTYFGRKDTQVKLHGQRIELEEIEHHLEQNLPQDWTSAVELIQFEGKKSLASFICADLGSVRSASNEKNTVLAMDDSFRSLAKELEIALSNNLPAYMIPSVWLPVSEMPMTSSGKLDRRSLRSMVQSLPASEMTSYKLALKSGRAPASDMEKQLASMWAHVLNVDANTIGVEDHFFRLGGDSIAAMQLVTLARKSNINLTVTGVFQKGSLLDMAQSALPLSRTAVATVYAFSLLPEVVSLDALKEEIGSCARIQVGDVEDIYPCTPLQQGLMALSAKEPGAYVAQLVFRLPNGTDLDNFKMAWRLVIEAEGTLRTRLVQTTDHGILNVVVKGDVPQWSTDRSLSDLQRLRSHLPSSNGGRLTDYAIVEDGSDVSFVWTIHHALYDGWCLPLILDRVKQCYEGIQSSTSEPIASGPTYSRFIRYLNETDSSQDVKFWESYLSDISTQHFPRLPDPDYKPSASGLIIHKTCFDNTRDGMKSVGLGITTATMIRSAWALTVSTYAASDDVVFWETMTGRDVPVEGIEEMVGATLSTVPTRIALDRSQKVSDLLSSVQAQSAVVRMHQFAGIHTIKRINTDTAFACGAQNLLAINYGPRTSTDSFWCDQTNEMAGTNFYSYPLMLSCHVADGELETVVHFDPDVICESQMHRVMDQFALMLTAVTSKDLVDEKLSELDLISTRDYQSLSEMNGQMVPSCDMCVHDVIKASGIAQPLDKLAVCAWDQNLTYEGLDSQSTHLSSALIEAGVRPNTFVPFCMEKSSMVVVSILAILKSGAAFVPLDYAHPDARISGIIADVEAEFVLSSPQYAERLTKLGAKVISVSKDTIQDSMPLQQHDLSVSTKSPAYCIFTSGTTGRPKGTIIDHSAFCTGALAHGKAMGMNESSRVLQFASHTFDASIMETLSTLIHGGTVCVPSEEERSQDIAGFIRRMSVNWALLTPSVAQLIEPSTVPELKTLVLGGEAMSRAHLSTWAPSVQLMNAYGPSETSVVATVNSNVTLDSSPANIGRAVGGLCWVVDSANADRLLPIGVVGELFVEGPILSQGYLKNSQKNAESFITNPRWCSKFTSETASSERRFYRTGDLVKITEDGSIEFQGRKDNQVKINGQRLELSEIEHHLNTDAIVQACLAFIPTTGPLKSRLVAVLSLHSTFVSRGPDEMQLVIDFARSELTSVRDSLTGQLASYMIPSMWIVVNRIPLLPSGKLDRRRVANWVEAMSPEQYQLAIGAQDESYASGLDREATETETKLRAAWAKVLGIEVESVPFTRSFIQLGGDSISAMQLVAICRSSNMALSVSQIMQSKSIVKLASFVQAVEDVTQDDEQEDKAFPLSPIQKLYFERMYSDSTHFNQSMVLETTRKITPQDLSNALEAIVKTHSMLRARFSDVDGAYSQRITSDIAGSYAFESHVGMDQCRVSELIEKTQKSLNIFQGPLLAAASIEMEDIDKQIVFLAVHHLVVDVVSWNIILQDLEGLLSSSASNLGKPLSFQTWNTLQLEESRNQTPDRVFHNLPTPAQDLAYWGMQAVPNIHGDAIAETIEIASDVSLQLLGPCHEALNTNVVDVLLASLLSSFHQAFPDRLSMPTIFNEGHGREPADNKLDLSRTVGWFTTLCPVYLPDSLPVQPDILDIICWVRDFRRRIPGNGRPYFAHQMLSESGQKESAEWPAELAFNYLGQRQKTELEGSLFKSPDGVLASVGSETDIGADVPRLALIEISASFSRDDLSFSFSYSRQMKHQPCIREWVKNFSATLQTAVERMTQAKAEPQDLDTSLLPLAFRATSKVDTRLAELGISCCADVEAVYPCSPVQMGILFAQIRNPEFYSYSVTFGVNCIEPSRVVDVQRLKDAWQRVVQRHSTLRTTFVDGLLEEGGINQVVLRNHCADISVFERADNDELQMITERIKPKIMSNKPPHHLSIFSSAEGKVTCVLEMSHALSDGTSMPILFRDLAMAYEGSLDPTIVSAYRDYVSYLQCQGPNDIEYWREYLTGAEPCHLPLASKSTLPRALGYLDQTISCAADLQAFCTGAGVTLSNVIQLAWALVLQAYTGHDDVCFGYLLADRDAPVDNIDNAIGVFINMLVLRVRLGSSQSVGDALGAVQQDLSAAIGHKNISLTDIQRVTGLLNEPLFNTAYSFQRRSISKSMANGSLSFDVREAQDPNEYDLTVNVEVWDQAAELQLCYWTDKISNSQAKTIASTFDKILTSIATCDLSLPTNQLDIVSDDCAQQLTRWNNTEPTLLDQCVHHVFERNVQSLPHDTPAIEAWDARFTYSEVDMLSSRLAHHLVSLGILPEMYVPLCFEKSAWTPIAMLAVLKAGAAFVPIDPTHPPERIEFLVQNTSAKLILCSTSLAEKFDIGVPFLAIDHETMSTLSALPVTSPSIAVQPNNAAYIIFTSGTTGLPKGTIVEHAAFTTGGTAHAAAIKMTCSSRVLQFASYTFDASIMEILTTFLVGGCVCVPSDEERMNDLAGTMAKYDVNWALLTPSVAKVLKPGSVPGLKVLVTGGEAMSTDHITKWLGHAALINAYGPSEASVIAASHTKVDENGVILNEEPANIGHAVGCRTWVVDPHNHNHLMPIGSIGELLLEGPILARGYLKNETKTTDAFIDYPPWRANMSLSGDRVDRMYKTGDLVSQNSDGSLNYVSRKDTQIKLNGQRIELGEIEHHVRANLPAHVQSAVELVVPQSKTSTKTLAAFFTVDDHEVLKETSDPLLPMSSAYMEIGQSLKTALRVALPTHMVPTMYVPLTKMPWTSAGKLDRQKLKTIVQSIAPQDIGGYKLVGASNSRAPTTMMQRKLQKIWAGILNIHPSTISIDDSFFRLGGDSISAMKVVSAARMEEISLTVMDILTSPTLSEMATCCGHSENTTVMEVEPFSLLHDVDSPPSLLDEVADCCDVPTSQIQDLYPCSSLQEGLVAASMQQPGAYVARYIFKVPSTIDMERLKMAWQNTSNHVDILRSRIVNARSLKTYQAILEPHAINWEHYTSLEAIADKTIQLPERNGGVLAKYAIIDSSDPDLRYFVWSVHHALYDAWSMPSLLNLVSQFYHEATTEQLAPPVPYANFARYLVDSDAQASDEFWKATFQNASGVSHFPTATLSDEESTYSSLQHTIQCRRDDLGADITIPTIVRAAWALLLGAHTGSDDVGFGETLSGRDIALEHVEDILGPTLTTVPWRVQIDRSATVGHFLHSLHKKSAEVIPHQHAGLQHIKRLGGSIAVASDFRNLLVIQASDEATDHQDLLQPLEENGNHKNFFTYPLVVECSIELNNLVLTIHHNETVMTSWQVERLAHQFDALVNQLSRLSQEPDRKVAELQFCSEEDLQMIKGWNNGTCDAVYDTIPSLFWQSVATYHDATSIRAWDGHLTYGSLAQHAGHLAKRLIQEGVKAETMVPCCMDKSLWTTVAMLAVVLAGGTIIPMDPAHPRARHAEIARECKAIIALCSPEYRDRFIGVVPTVIAIDQTLFTKQLCQDHIASEDLPLVADKDAAFVIYTSGSTGKAKGVVIEHGSFVASSRAYIKHMNLSATSSVFHFTSYAFDIAMGETFGALTTGACLCVPSEEMRVTDLPGVMNTLGATWAFLTPSLANMQDPSMFKTLQALVCGGEAMTSETVSKWSNKVKLINGYGPAECTVFALSNSNVSEDQDHSNIGRAMDGCQTWIVDTRDHNKLVPVGCEGELLISGPILSRGYLNDSAKTSKSFIENPAWMHHFDDKKHQNPVRLYKTGDLVRYRPDGNLTFIGRKDNQVKLHGQRMELGEIEACLESDPRLRNALVALPKSGVFKGRLVAVLSFKDSDSHNPGLVSSQFSPISESDMDVARLHLPDLQQILSENLPPYMMPSSWLVVEAIPLLLSGKLDRASTQKWLTEMVAETPEFLLDQQLGQDAGATDTTFVGQLLRKIWASVLRIPDESKLSGRSFISLGGDSIMAMQVMSRCRDHSIQLTMRDIMSGKSISDLVTLIEKEGRGKQTVNPEYEEDNSRPFALSPIQQLFFNNSNDKDRGDRFNQSQLFSITESIDKDTFANAIHALVQRHPMLRARFNKSSTTGQWSQQVAPDTEDSYGLHFHEVSDASQIARQIAASQESIGISGPVFIVDLFKMPDGHHHVSMIAHHLVVDVVSWINIAQDLETLLSTSPSMSSKPLSFRKWNAAQTEHATSVAKKNEDLLPFTVRPANLDYWGVSGVSNSYSQVTQQSFSLSDVDTVSLLLGDAHQALRTEPLDLFISALLISFGQCFPDRELPTLFNEGHGREPWDDSIDLSQTVGWFTSLCPIDISHHNADPTYTIDYVRKVKDVRRAIPGNGRPYFAQRYLTDSGKQSLDAHEPMEILLNFLGRSQQSGEDDSILRLSNLSMSDEDMASMSDVGPETRRLALFELSISILDEGIQFTFMYNKNMLHQDLIQQWVITCKEVLGNMAMELSTAPSCPTISDFPLMSLDYAELNKLVTKSLPTAHVRFDEVEDMYPCSPMQMGILISQLLDPSQYLFYAVLEVSASSRSAIDSAKLAQACSEVVERHDALRTVFIESVRSGGSFDQVVLRPGKPRIATFKCREIDVMAKLNTRSLGKTNKRHGVPILPYQITICETPQGKVFIKLEMNHAVTDGASTAIVLRDISSAYANNLHPTKAPSYKEYINYITKQPSDSSLMYWKSYLYGARNTEFPAMNSDHISGRSLGSIAVDFDRFSELQSLGLDAGVTFSNMIMVAWALVLRKYTNSQDVCFGYLGSGRDADIDGVDEIVGPLINMLVFRFQFTHSMLLKRLFLDTQEDYANSLPHQHFSLARVSHELGQSKRGFFNTAVSIQNAGASSDADFSALKFESVDAFDPSEYAVTLNANTTRGDEGIVFRYWTNILSHSQAKELAIVMSEVLSDMIDHSEEALSHLRVSQDSSLPTNPAQDLHGWTFEHSDTSEQFKTTNSTISSYSTGPGATLFSPATSWGSLPRDKDQVYNKLSALWKQHLDVATTDLTYDGSFFEYGGDSIIAMAMVGDARDRDLPLTVADIFKNPSFGTLLNCLRDKSYREGDMVSSDGNISLSGSKKEGIVVDEHTYEPLSLLPQQNAEQFVREHVCPVVGVSRASITDVLPTTDFQAQAIEGSLLDSRWMLNYFHLDGEGPLDVALLQESITNVIASYDVLRTVFVPYEATYLQVILRHVQSELIFHDVDDVEQFTLDLESDHLRQIPSPEKPSLRFILARHEPSERHRLFIRLSHALYDGVCFPAILNALKASYEGEPIATTPSYATYIHGLFSKANPDQHTYWRSLLEGSAPTNLIPRECRSMRTNPTQALRKIVATPSLATVNITTATVIKAAWSVVLAKNTGTRDVVFGHLISGRNSCHVPGIEAIVGPCLNVVPVRVQYQDSWMVLDLLQHIQHQQVDNIPHESLGFREIIRNCTNWDDDGANGFSTVVQHQSMAQTGSLDIGDNTYEVGVIASQEDTADFSVVTTPQDSSNTEVCFLYREGGVERTEFAEKLFDCLCSTIGDLSRDVKTPLVSWL
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the fusahexin, a cyclic hydrophobic hexapeptide with the amino acid sequence cyclo-(D-Ala-L-Leu-D-allo-Thr-L-Pro-D-Leu-L-Leu) that plays an important role in cell surface hydrophobicity (PubMed:22862913, PubMed:34292732).  Fusahexin might also play a role in virulence, sensitivity to osmotic stress and oxidative stress (PubMed:34292732).  NRPS4 is the only enzyme within the cluster and its 5 catalytic modules are sufficient to produce fusahexin (PubMed:34292732).  The modules 1 to 4 incorporate respectively D-alanine, L-leucine, D-allo-threonine, and L-proline, which is supported by the presence of epimerase domains in modules 1 and 3, which incorporate D-amino acids (PubMed:34292732).  The terminal module is responsible for incorporation of the two adjacent leucine units, where the epimerase domain is only used to convert the first unit to D-leucine (PubMed:34292732).  The terminal condensation domain (Ct) is involved in cyclization with D-alanine and thereby releasing of fusahexin (PubMed:34292732).
What are the official names of this protein?
Nonribosomal peptide synthetase 4, NRPS 4, Fusahexin biosynthesis cluster protein NPRS4.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.