PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_SHIBS
Sequence: MSAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEDVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CH2BB_XENLA
Sequence: MASLFKKKTVDDIIREQNKELRGTQRAITRDRAALEKQEKQLEMEIKKMAKTGNKDACRVLAKQLVQLRKQKTRTYAVSSKVTSMSTQTKVMSSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTDEMINDTLDDIFDASEDEEESQDIVNQVLDEIGIEISGKMAKAPSAAKGLPSTSAAKSKGISDEEIERQLKALGVD
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 2b-B, Chromatin-modifying protein 2b-B, CHMP2b-B.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
Protein: GPMI_LARHH
Sequence: MKSVTPVLLLILDGFGHRLDGDDNAIALARTPNWDRLRRDHPYGTIDASERAVGLPRGQFGNSEVGHLNIGAGRIVTQDISRIDLDLEEQRFAGNPAFTHAFAAARGHALHILGLLSDGGVHSHENHIHALIRAAQAAGVADIRVHAFLDGRDTPPRSARTYLERLDAVLAECPNARLATVCGRYFAMDRDKRWERVEQAYRLIVDGEAAFQADDGLSALAAAYARDENDEFVRATRIGAPAPMQDGDAVIFMNFRADRARELTSALTDPEFDGFSARQLRLSDYVTLTRYGADYASLSIAYPPQTIRNGFGEYLASQGLRQLRIAETEKYPHVTYFFNGGEETVYPGEDRILVPSPKVATYDLQPEMSAEEVTNRIVEAINSRQYQAIICNYANGDMVGHTGNLPAAIRAVETLDGCINRCVEAMLANGGEVLITADHGNCEQMDDPLHQQPHTQHTTNLVPLCYVGHRPARILEGGALKDIAPTLLALMGLPAPDDMTGHSLVELL
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: WDR74_BOVIN
Sequence: MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGTLITCVDSGILRVWTDKDKEASSDPVLELRVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS
What is the function of this protein?
Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit.  Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL.
What are the official names of this protein?
WD repeat-containing protein 74.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Note=Nucleolar location depends on active PolI transcription of pre- rRNA.
Protein: SCML1_HUMAN
Sequence: MMSNSSSEIDVIKTRIPTYDEDDNTILYAYETKPEFVNKEPNIVSDASCNTEEQLKTVDDVLIHCQVIYDALQNLDKKIDVIRRKVSKIQRFHARSLWTNHKRYGYKKHSYRLVKKLKLQKMKKNEVYETFSYPESYSPTLPVSRRENNSPSNLPRPSFCMEEYQRAELEEDPILSRTPSPVHPSDFSEHNCQPYYASDGATYGSSSGLCLGNPRADSIHNTYSTDHASAAPPSVTRSPVENDGYIEEGSITKHPSTWSVEAVVLFLKQTDPLALCPLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQGKCFEN
What is the function of this protein?
Putative Polycomb group (PcG) protein.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  May be involved in spermatogenesis during sexual maturation (By similarity).
What are the official names of this protein?
Sex comb on midleg-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YF001_HUMAN
Sequence: MAAAGVTAKAGGGTSAAAASLIRARSPAWPRRAVSCSLARGTGAPKCGSDSTPPPPLPRRRSRARRGHLGNGDRPSAGATVGGEGQASQIGGGGGGGGGRRNATGRGRRRRQGGAGSAVKCRRDSVLEPGLASSPGVAPAGGSGGLWSGAGLCSGLGARGFPGGRRSGRDAG
What are the official names of this protein?
Uncharacterized protein FLJ37310.
Protein: GIMA7_HUMAN
Sequence: MAESEDRSLRIVLVGKTGSGKSATANTILGEEIFDSRIAAQAVTKNCQKASREWQGRDLLVVDTPGLFDTKESLDTTCKEISRCIISSCPGPHAIVLVLLLGRYTEEEQKTVALIKAVFGKSAMKHMVILFTRKEELEGQSFHDFIADADVGLKSIVKECGNRCCAFSNSKKTSKAEKESQVQELVELIEKMVQCNEGAYFSDDIYKDTEERLKQREEVLRKIYTDQLNEEIKLVEEDKHKSEEEKEKEIKLLKLKYDEKIKNIREEAERNIFKDVFNRIWKMLSEIWHRFLSKCKFYSS
What is the function of this protein?
The dimer has GTPase activity; the active site contains residues from both subunits.
What are the official names of this protein?
GTPase IMAP family member 7, Immunity-associated nucleotide 7 protein, IAN-7.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
What are the subcellular locations of this protein?
Lipid droplet. Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets.
Protein: TX308_LYCSI
Sequence: MKFVLLFGVLLVTFFSYSSAEMLDDFDQADEDELLSLIEKGEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1a, Toxin-like structure LSTX-B8.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL32_ECOSE
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CLAMP_BPT4
Sequence: MKLSKDTTALLKNFATINSGIMLKSGQFIMTRAVNGTTYAEANISDVIDFDVAIYDLNGFLGILSLVNDDAEISQSEDGNIKIADARSTIFWPAADPSTVVAPNKPIPFPVASAVTEIKAEDLQQLLRVSRGLQIDTIAITVKEGKIVINGFNKVEDSALTRVKYSLTLGDYDGENTFNFIINMANMKMQPGNYKLLLWAKGKQGAAKFEGEHANYVVALEADSTHDF
What is the function of this protein?
Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis.  Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (PubMed:10535942).  Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template (PubMed:22194570).  During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it (PubMed:33602900).
What are the official names of this protein?
Sliding clamp, DNA polymerase accessory protein Gp45, DNA polymerase clamp, Gene product 45, gp45, Sliding clamp Gp45.
What is the protein family that this protein belongs to?
Belongs to the Tevenvirinae sliding clamp family.
Protein: OBG_ACIC5
Sequence: MFIDEAKIRVKAGDGGNGCMAFRREKFVPRGGPSGGDGGRGGDIVMESTQRHNTLLYFRYNPEHKAERGEHGMGSNCTGRDGKDIILKVPVGTVVYNAESGELLHDFQQPDERLIVAHGGRGGRGNQHFATSTHQAPREHEMGYPGEEFTLRLELKVLADIGIVGYPNVGKSTLISRISAAKPKIADYPFTTLEPNLGVVTVGEMPHEETFVVADIPGLIEGAHEGAGLGDRFLRHVERTHLLVHLVDVSDASGRPDPVADYKTIAAELANFGGELEDKPVIVVASKIDSVNPDKLKKLAAMAKRRKLPFYEISAVTGQGVQQLKYAMAERVRELRKQTQIEL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_ACIC5
Sequence: MSSAPNIFLSAGEASGEHYGAALIPALRALYADARFFGLGGQRMQALGMERIVRAEDVAVMGITEVVRHLPRIYGEYLKLKRSIIERKPDLAILIDFPDVNLSLARTLHEQGTPVLYFVSPQLWAWKKYRIRKVQRYVDRMLVIFPFEEAFYQGHGVQADFVGHPLTEVPLPTITRAEFAAAHHLDPAKHWVGLLPGSRGKEIRLNLPEMIAAAKQLGHEHEYVLPLAPTLTEAQRGHVRQMLAALTASAHDAAHDQAPRITVVADARATLHHARASIVASGTATVEAALIGNPFVVVYRVSPLSYAIARRVVTVPHVAMANLIADRRVVPELIQDDFTAANIVREMQPLVASDRAREQMMTGLAEVRAKLSTPGSSAIARVTKVAHEMLQRRAALSRVR
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: G3ST2_MOUSE
Sequence: MWGSQHRSFQVALWFLVLAVFLLVGFLHVDFRLLIPDKVQEPPVTNIMFLKTHKTASSTILNILYRFSESHNLSTALPEGSRVHLGYPWFFVTRYVEGLKQDAHLQHHFNIMCNHLRFNYPEVQKVMPRDTFYFSILRNPVFQLESSFIYYKDYAPAFQRAKSLDEFLADPWKYYNASVSLKNVYAKNNMWFDFGFDNNAPADMDYVRKRLAEVEQRFHLVLIADYFDESMVLLRRRLRWQLDDVVSFKLNVRSQSTVSHLTPESQERVQHWCALDWQLYQHFNRTFWTQLHAELSPRQLTEEVEQLRERQRELMALCLQDPEPKNLTHIDDQNLRPYQGGKANILGYNLRHGLDTTTLHICQRMAMPELQHMAHMYSLQFPDKTPKDIPFLKK
What is the function of this protein?
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues.  Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).
What are the official names of this protein?
Galactose-3-O-sulfotransferase 2, Gal3ST-2, Beta-galactose-3-O-sulfotransferase 2, Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2.
What is the protein family that this protein belongs to?
Belongs to the galactose-3-O-sulfotransferase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: NCAP_LBVAV
Sequence: MAHPKLKMLDAFSDVVEITGKTAGKESWDDESTIAMPSYKLSVLSDADAVREVKIFLTGLFVRSSPRAIAAALIMTWNMRSVDPVAVRIFPAKDKGKDTADVDVKNLEVPGVDYIDAMVETNVKDASDIEIIRAGAFIAASTLKMFAKSFTGWTQAWEHKHIQKRYADFCKTEYPFKEFTTNNKCAETMYEAYQGQKLYQGTLGRILYALGDVADPRQTEMLFDQHLANTGMHIIPQFTNAQLSIGATTAGLLSALNYGQNFGTLMQLKKLINESLSKPPGPDNRATWRFARIFDPSVFQTLQTKYCADTVAILANINSMGKLSTETSNPLNIAVLKQMAPERKRYTRQVAKNIYHHFMVVARALNNDMFDTDKYKFVESDDEEEHVANEGETPVKE
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: FADA_PECAS
Sequence: MEKVVIVDAVRTPMGRSKGGAFRQVRAEDLSAHLMRSLLSRNTALDAREIDDIYWGCVQQALEQGFNVARNAALLAEIPVSVPATTVNRLCGSSMQALHDAARAIMVGDANVCLIGGVEHMGHVPMNHGVDFHPGLSRTIAKAAGMMGLTAEMLARMHNISREMQDQFAARSHQRAYHATQSGAFRHEIVPTAGHDADGALQRFDYDEVIRPDTTIDSLAALKPAFDPVNGTVTAGSSSALSDGASAMLIMSESRAASLGLPVRARIRAMAVVGCDPSIMGYGPVPATKLALKRAGLSLADIGIFELNEAFAAQTLPCIKDLGLLEQLDEKVNLNGGAIALGHPLGCSGARISTTLINLMESRDAQFGVATMCIGLGQGIATVFERA
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y454_CITK8
Sequence: MKKKTSLSEEDQALFRQLMTGTRQIKQDTIVHRPQRKKITEVPVKRLIQEQADASHYFSDEFQPLLNTDGPVKYVRADVSHFELKKMRRGDYSPELFLDLHGLTQQQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELP
What are the official names of this protein?
UPF0115 protein CKO_00454.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: Y1080_BURCH
Sequence: MPPMTRKTRIQPIEPVAEEDDNGYDRPSKSQLKREMHELQVLGQALVDLPKDALKRMPMPESLGDAVREARRITDHEGKRRQLQYVGRVMRSLTDDETAALRTALDAQRGVNKAATARLHWIERTREQLLASDDALTEFLRQHPDADIQEGRTLIRNARKEAQQGKPPRYFRELFQWIKAAGGASDSDDEAADDAGDDHDDEA
What are the official names of this protein?
UPF0307 protein Bcen2424_1080.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: RBFA_BRUO2
Sequence: MARSHDTKGSGGLSQRQLRVGEQVRHALAQVLQRGEIRDDLIERTVISVSEVRMSPDLKIATCFITPLGSADPQAVIKALASHAKFIRGRVAPSLAQMKYMPEFRFRPDTSFDNFSKIDALLRSPEVARDLSHDDDEDGGADEAPRNGDE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDH2_COLMA
Sequence: MSTDNSKIIYTITDEAPALATYSLLPIIQAYTASSGINVETRDISLAGRILANFPKYLTKEQRIDDALAELGELAQTPEANIIKLPNISASIPQLEAVIKELQAKGYDLPHYPAEPQNEAEESIKLTYAKILGSAVNPVLREGNSDRRAPASVKQYARNNPHSMGAWSKESKSHVAHMASGDFYGSEKSVTIDGATSVNIEFVAKNGDVTLLKSKLPLLDKEIIDASVMSKSALVEFFETEINKAKEEDVLLSLHLKATMMKVSDPVMFGHAVRVFYKDVFAKHAATFEQLGVDADNGIGDVYAKIARLPAAQKEEIEADLQAVYATRPEMAMVDSDKGITNLHVPSDVIIDASMPAALRASGMMWGPDGKQKDTKFMIPDRNYAGVFSAVVDFCRENGAFNPATMGTVPNVGLMAQKAEEYGSHDKTFTMKAAGTVRVVNSQGERLIEQEVAQGDIYRMCQVKDAPIQDWVKLAVTRARATGTPTVFWLDENRGHDEQMIKKVNTYLADHDTTGLDIQILEPVKACEFTLARVAKGEDAISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENHLRWDSLGEFLALAASLEHVAVTTGNARAQILADTLDAATGKFLDTNKSPSRKVGELDNRGSHFYLAMYWAQALAAQTTDTELQASFSSVAQALTKQEEKIVAELNAAQGPAIDLNGYYFADTKLAEKAMRPSETFNTILSALL
What are the official names of this protein?
Isocitrate dehydrogenase [NADP] 2, IDH-II, IDP-2, NADP(+)-specific ICDH 2, Oxalosuccinate decarboxylase 2.
What is the protein family that this protein belongs to?
Belongs to the monomeric-type IDH family.
Protein: QUEA_VIBCM
Sequence: MQVSDFHFELPDELIARYPKAERTASRLLQLDGNSGQLVDGTFKDVLELVEPGDLLVFNNTRVIPARMFGRKASGGKLEVLVERMLDEHTILAHVRSSKPPKPGTELYLGENDEFHAVMQARHDALFEIRFTAETVVLDILNQIGHMPLPPYIDRPDEEADKERYQTVYNQKPGAVAAPTAGLHFDQALLEQIQAKGVELAYVTLHVGAGTFQPVRVENIHDHHMHAEYVEVPQEVVDAITATKARGGRVVAVGTTSVRSLESAAQDALQKGTELKPFFGDTEIFIFPGYQYQLVDCLITNFHLPESTLIMLVSAFAGYEHTMAAYEHAVKEQYRFFSYGDAMFIRKQMTKA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_BRUAB
Sequence: MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKKLDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVDLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSSVHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVDTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRYEGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAVDDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ENO_STRTR
Sequence: MTVTIENIHAREIFDSRGNPTVEVDVRLTDGTLGRAAVPSGASTGDREAVELRDGGARLQGKGVSKAVANVNGEIYEALKGQSPFNQAKLDHLMIELDGTENKSCLGANAILGVSMAIFRAAANSEKIPLYRYFGGVDLELPQPFFNVINGGVHADSGIDVQEFLITPVKRDSFRDGLKKIANIYHTLKKILSDKGLKTPVGDEGGFAPKLGTTENAIAILYQPIDSAGYFPGEKIAIAIDSSSIEFYDDKKKFYRFEGKNLTSKELLTYYDNLVEKYPALISIEDGFSEHDWEGFAAQTKARGQKIQLVGDDIFVTNPTIFKEGIKKNVANAILIKLNQIGTVTETIETISLARKAGYKTMISHRSGETVDSYIADFSVAMHAGQIKSGSMARSERVEKYNQLLRIEEDLGKDVALAQFPG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: EIF2A_MOUSE
Sequence: MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV
What is the function of this protein?
Functions in the early steps of protein synthesis of a small number of specific mRNAs.  Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits.  In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
What are the official names of this protein?
Eukaryotic translation initiation factor 2A, eIF-2A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIF2A family.
Protein: RS18_AERS4
Sequence: MARYFRRRKFCRFTAENVTEIDYKDIVTLKNYVTESGKIVPSRITGTRAKYQRQLARAIKRARYLALLPYTDLHNK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SURE_CUPPJ
Sequence: MHILLANDDGYLAPGLAVLHAALAPLGRITVIAPEQNHSGASNSLTLQRPLSIYEAREGVQKGFRFVNGTPTDCVHIALTGLLDEKPDLVVSGINQGQNMGEDVLYSGTVAAAIEGYLLGIPSIAFSQLHKGWEHLDAAARVARDIVERAIATPPVEPFLLNVNIPNLPFEHIKGYRATRLGKRHPSQPVIAQVNPRGDLNYWIGAAGDARDASEGTDFHATAEGYVSLTPLQLDLTHRSQLEALAQWLN
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPEB_APLCA
Sequence: MSQSPQTVDQAISVKTDYEDNQQEHIPSNFEIFRRINALLDNSLEANNVSCSQSQSQQQQQQTQQQQQQQQQQQQQQHLQQVQQQQLLKQQQQQAQQQQIQQQLLQQQQQKQQLQQQQQQEQLQQQQLQLQQQLQQQLQHIQKEPSSHTYTPGPSPELQSVLNYANVPLSKSAAFNCNNSSSYSVGPTPVQSPVTPSPAASAVTVNSPSYGNFQLFGENAFDSTTPFQSDGTSQSHSRSLANDSDPMVVMSPGRDSIIPLSPTEKILYQNFLLSKQAQGENTALPPSPPHEIMPLSPLEKKLYSNLLSKHTQGMRAINSTSPLQTPLTPPRSPQEVLYASMPAAQVGESSSVIDMMSRMDLSGRNQQADYSGTLAFLDAHNVLRRRTPSSSRSRSVMERSAPSSYFANLDPYAIDRAARLHRNAAAVGEASCTWSGHLPPRNHENPVYSPKVFLGGVPWDITESGLQAAFSKYGHLKIEWPGKDGYVHLLFDVEKSVRSLLQACTHDFSNGDYFYKISSRRMRSKEVQVIPWVLADSNHVFQPSQRLESNKTVFVGALHGMITAEALGRIMSDLFGNVVYAGIDTDKHKYPIGSGRVTFSSRKSYMKAVQAAFVEIKTPKFTKKLQVDPYLGDAICSLCNSHQGNYFCRDLLCFKYLCRSCWYWQHAPDSMRQHRPLTRNTKSSLSL
What is the function of this protein?
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation (PubMed:14697205).  In its amyloid-like oligomeric form, acts as a translational activator (PubMed:14697205, PubMed:21270333).  Up-regulated at activated synapses where it is required for the late phase of memory-related long-term synaptic facilitation (PubMed:14697206).  Sustained CPEB-mediated protein synthesis for at least 72 hours after neuronal stimulation is required for the persistance of synaptic facilitation (PubMed:18817739).  Activates translation of atypical protein kinase C (PubMed:26095361).  Required for the relocalization of syntaxin mRNA to the axon hillock from the opposite pole in the cell body of sensory neurons during long-term facilitation (PubMed:16687512).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein, CPE-binding protein, CPEB.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Synapse, synaptosome. Cytoplasmic granule. Note=In sensory neurons, detected in cytoplasmic granules composed of proteins and RNA.
Protein: RL6_CHRVO
Sequence: MSRVAKNPVAIPAGVEVKFGAADVTVKGALGSLSTALCNDVEVKLDNGQLTFAAKNDSKFARAMSGTLRALLNNMVNGVSKGFEKKLQLVGVGYRAQAQGDTLNLSLGFSHPVAHKMPAGIKVETPTQTEILVKGADKQLVGQVAAEIRAYRSPEPYKGKGVRYADEVVVLKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SSPH2_BACC1
Sequence: MNIQRAKELSVSAEQANVSFQGMPVMIQHVDESNETARIYEVKNPGRELTVPVNSLEEI
What are the official names of this protein?
Small, acid-soluble spore protein H 2, SASP H 2.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.