PharMolix/UniProtQA huggingface dataset:
Protein: HIS8_MYCVP
Sequence: MTGVPGSSITLDDLPLRDDLRGKSPYGAPQLSVPVRLNTNENPHPPTRALIDDVAQSVREVAGELHRYPDRDAVALRTDLAAYLSAQTGTAVGVENVWAANGSNEILQQLLQAFGGPGRSALGFVPSYSMHPIISDGTQTRWLVANRGDDFGLDAAVAATAIKEHTPDVVFVTSPNNPSGQSVSLDDLRLLLDALCLQDGGVMIVDEAYGEFSSQPSAIGLIESYPGKLVVTRTMSKAFAFAGGRVGYLVAAPAVIDAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVATLIAERERVSQALTGMGFRVIPSDANFILFGEFADAPATWQRYLDEGVLIRDVGIPGYLRTTIGLAEENDALLAASARIGAP
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: EX7S_ECOBW
Sequence: MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIM5_SAGLB
Sequence: MASGILVNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESTPHQGERSCPLCRMSYPSENLRPNRHLANIVERLKEVMLSPEEGQKVGHCARHGEKLLLFCEQDGNVICWLCERSQEHRGHHTLLVEEVAEKYQEKLQVALEMMRQKQQDAEKLEADVREEQASWKIQIRNDKTNIMAEFKQLRDILDCEESKELQNLEKEEKNILKRLVQSESDMVLQTQSMRVLISDLERRLQGSVLELLQGVDDVIKRIETVTLQKPKTFLNEKRRVFRAPDLKAMLQAFKELTEVQRYWAHVTLVPSHPSYAVISEDERQVRYQFQIHQPSVKVNYFYGVLGSPSITSGKHYWEVDVTNKRDWILGICVSFKCNAKWNVLRPENYQPKNGYWVIGLQNTNNYSAFQDAVKYSDFQIGSRSTASVPLIVPLFMTIYPNRVGVFLDYEACTVSFFNVTNNGFLIYKFSNCHFSYPVFPYFSPMTCELPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: LEUC_PROM0
Sequence: MSKDTLFDKVWDLHKVSSLPGGSDQIFIGLHLIHEVTSPQAFGALKDKNLRVKFPSRTVATVDHIVPTDNQSRPFKDNLAEQMIETLEKNCIEHKIRFFNIGSGNQGIVHVVAPELGLTQPGMTIACGDSHTSTHGAFGSIAFGIGTSQVRDVLATQTIAMNKLKVRQIWCENKLSNGVYAKDLVLHIINKLGVKAGVGFAYEFAGPAINSLSMEERMTICNMSIEGGARCGYINPDEKTFSYIKNKLCAPRNENWDEALLWWKSLKSDANSIYDDVTKIDASKVEPTVTWGITPGQSVGINQKIPLLEELSPDDQFVAKEAYEYMGFKPGQSIKDTPIDVCFIGSCTNGRISDLRVAAKVVKDKKVSQNIKAFVVPGSEKVAKEAKIEGLDKIFLDAGFQWREPGCSMCLAMNSDKLIGNQLSASSSNRNFKGRQGSPNGRTLLMSPAMVAAAAISGKVTDIRNFM
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: APOC1_PTEGI
Sequence: MRLILSLPVLAVVLAMVLEGPAPAQADPHISSSLESIPGKLKEFGSTVEEKFRTAIDHIKKSEFSEKTQNWFSELFHKVKEKFETTF
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CACB3_RAT
Sequence: MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLDDACEHLAEYLEVYWRATHHPAPGPGMLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHDHNDRNWQRNRPWPKDSY
What is the function of this protein?
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:7679112, PubMed:10666413, PubMed:24751537, PubMed:29742403, PubMed:15170217).  Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).  Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:7679112, PubMed:10666413, PubMed:24751537, PubMed:29742403, PubMed:15170217).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMM82_XENLA
Sequence: MGFISYFSSFLPDIPWHFWGSVDSLLQGLVGACAVSVLYNLTRVHLYIMCLNDPDKQKEAAQLRAQSLLMDFLHVSLLTLIYSLLGPRVGALVVLEFSLRAVSMVLSVSKGAGSSQLFLLCQFSLGCGVSCSLDYLHEGAPHRTWNLLLAVGLSWLILWQSRRMCRHVGIMYQLHSRERYCGVCLSLLASWHDIPPFLRRALKVAFLVSDLAAVAVINRDFLSTSEAMRFWTPLTICYTLLVIYMQEEQQQNPSEQMVYQTVFVRMGGLLILMMTVGRWADILHIFISLTGEIWCLIHAGVMLRICREQDFADRISSPRKAPISRGSIYTRDGRTLQRETSLEE
What are the official names of this protein?
Transmembrane protein 82.
What is the protein family that this protein belongs to?
Belongs to the TMEM82 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL6_CAMJD
Sequence: MSRIGKQPIAIPAGVEVKLEGNLLKFKKGNLAKELDTKANVNVEIKDNNILFSPKGEDRQSRAYWGTYRALAYNIVVGLTQGFSKTLEINGVGYKAALKGKVLELSLGFSHPINYDIPGGIEIVVDKNTIAVKGSDKQVVGQVAAQIREFRPPEPYKGKGVKYSDERIIRKAGKTSKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ATPF_SACHY
Sequence: MKNVTHSFVFLAHWPFAGSFGLNTDILATNLINLTVVVGVLIFFGKGVLKDLLDNRKQRILSTIRNSEELRRGTLEQLEKARIRLQKVELEADEYRMNGYSEIEREKENLINATSISLEQLEKSKNETLYFEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANIGILGAIEWKR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS9_MARMS
Sequence: MSATQYYGTGRRKTSTARVFLKAGSGNLVINNRSIDQYFGRETARMVVRQPLELVDATEKFDVYITVKGGGISGQAGAIRHGITRALMQYDETLRRTLRSAGFVTRDSREVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: DNAK_SHISS
Sequence: MGKIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQTAGADASANNAKDDDVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PUR9_CAMJJ
Sequence: MRALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVKTLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMSDDFDEIIENIDIGGPAMIRSAAKNYKDVMVLCDPLDYEKVIETLKKGQNDENFRLNLMIKAYEHTANYDAYIANYMNERFNGGFGASKFIVGQKVFDTKYGENPHQKGALYEFDAFFSANFKALKGEASFNNLTDINAALNLASSFDKAPAIAIVKHGNPCGFAIKENLVQSYIHALKCDSVSAYGGVVAINGTLDEALANKINEIYVEVIIAANVDEKALAVFEGKKRIKIFTQESPFLIRSFDKYDFKHIDGGFVYQNSDEVGEDELKNAKLMSQREASKEELKDLEIAMKIAAFTKSNNVVYVKNGAMVAIGMGMTSRIDAAKAAIAKAKEMGLDLQGCVLASEAFFPFRDSIDEASKVGVKAIVEPGGSIRDDEVVKAADEYGMALYFTGVRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RL35_NEIMA
Sequence: MPKMKTKSSAKKRFKVLGNGGVKRAHAFKRHILTKKTTKNKRQLRGTSMVNDRDLASVAKMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PTH_MALP2
Sequence: MSKYLVVGLGNPGLEYEKTKHNVGFMCIDELLKEHTLFLNNSKFNGQFVKVDQPEDQIFIAKPMTYMNNSGEFVYEICKFYKIHEQNILVIYDDIDTDVGKIRVKAKGSSGGQNGIKSIISKMNTEKIKRIRIGIGKPVHNLTHHVLTKFSAEDSIKVQQAIIKAKDACNEFLNHVDFDKIMNKFNV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_SERP5
Sequence: METTFRSALVKNFLGQSPDWYKLAILVFLVVNPLVFFLVDPFIAGWLLVVEFIFTLAMALKCYPLLPGGLLAIESVLIGMTSPDRVGEEIAHNLEVLLLLIFMVAGIYFMKQLLLFVFTKLLLNIRSKMLLSLAFCFAAALLSAFLDALTVVAVVISVATGFYSIYHNVASNRSDGNDGNIDVGDDSTLVSDDHKQTLEQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKSAGWGFVDFFLRMAPVTLPVFACGLLVCLLLERFGVFGYGAKLPERVREVLTEFDRQATAGRSKQEQVRLVVQALIGIWLVVALAFHLAEVGLIGLSVIILATSLCGVTDEHAIGKAFQEALPFTALLTVFFTVVAVIIEQHLFTPIIHFVLQAQPSSQLALFYLFNGLLSSVSDNVFVGTVYINEARAAFENGVISLKQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLVRLSYGRMVWMALPYTVVLTLVGLLCVQFTLAPATELLTQWHWLTLPSIEAATH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CDC42_YEAST
Sequence: MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLRDDKVIIEKLQRQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPPVIKKSKKCAIL
What is the function of this protein?
Involved in development of cell polarity during the cell division cycle, and essential for bud emergence.  Affects signaling in the pheromone-response pathway through the STE20 protein kinase.  Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.
What are the official names of this protein?
Cell division control protein 42, Suppressor of RHO3 protein 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: INVO_SAGOE
Sequence: MSQQHTLPVTLPAALSQKLLDTVPPPVNTQQEQRKQPAPLPPPCQKVPVELPVEVLSKHEEKHMTIVKGVPEQECEQQQPQEQELQQQHWEQDKEHQKAENPEQQLKQEKVQREKQQLQGQLEEEKKLLDQQLDQELAKRDEQLGTKKEQLLEFPEQQEGQLKHLEQEEGHLELPEQQEGQLKNLEHQEKPLELPEQQEGQLKHLEQQEKPLELPEQQEGQLKHLEQQEGQSELPEQQRGQPKYLEQEEGQLKHLEEQKGQLKHLEHEEGQLELPEQVGQPKHLEQLEKQLEHPEQQEGQLKHLEEEEGQVKHLGEQEEQLKHLEQQEEQLKHLEQQEGQLEHLEQQEGQLKHLEQHEGQLELPEQQVGQSKHLEQEEKQLEHPEQQEGQLKHLGKQKAQLELTEQVGQPKHLEQQEKQLEHPQQQEEQLKPQEQQEGQLKDLEQQERQLEQPVFASAPGQVQDIQQALPPKGEVLLPVEQQQQKQEVQGQHE
What is the function of this protein?
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
What are the official names of this protein?
Involucrin.
What is the protein family that this protein belongs to?
Belongs to the involucrin family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Protein: SYH_THEVB
Sequence: MGLQAPRGTRDILPAERVYWQYLETIARQILDRAAYREICTPIFEQTPLFERGIGEATDIVSKEMYTFRDRAQRSLTLRPEGTAGVVRAYIEHGLHSQGGVQRLWYLGPMFRYERPQSGRYRQFHQLGVEVLGSADPRADAEVIAVALDILQALGLKQLTLMLNSVGDREDRSAYRQALVDYLTPYKADLDPDSQERLHRNPLRILDSKDPRTQAIVKEAPRLLDYLSARSRAHFEQVQSLLQALGIAYQINPALVRGLDYYTHTAFEFQDMSLGNEGTVCGGGRYDHLVEELGGPPTPAIGWAMGLERLILLLRDRPLPARNQPYLYMVTRGAAAERQGLILAQQLRHQGYTVDVDLSGSAFGKQVKRADRVGATVCLVIGESEATDGTVQVKWLASGEQVLVPQQELLSENWRSRFLTPHDGLLSH
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB2_I01A2
Sequence: SVKKEEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPSTEMSLRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSS
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: GATE_DESA1
Sequence: MSRINYSETGLKVGLEIHVQLDTARKLFCKCPTLLSEAEAREVFTRYLRPAKSEVGEIDRAALLEWKKNKKYEYEAPVESSCLVEADEEPPHEINEDALLVALALASSMNMRIINEIHVMRKMVIDGSNVSGFQRTALIAVNGYIMDNEEKIGIQTLCLEEDAARKIDESETTVRYRIDRLGIPLVEVATAPDIHDPEQAVRVALKIGQLIRLTGRAKRGLGTIRQDLNISIKGGAKVEIKGVQHLYLISKVIEYEVLRQLKLLEIRDELVKRGVSPENISDNIIDVTDVFRDTGSKIVKKALSIPGGGVYAVVLRGFKGLLGIEIQPGRRFGSELADYARIWGGVGGIFHTDELPNYGITREEVQALYMKTGADPGIDAIVIVADVKQKAVEALKAVVERARIAVIGVPEETRAANPDGTTKYMRPRPGSARMYPETDIPPIYITPELMEKASKLIPEPPEKKLEKYVREHGLSTELAKAVINDLRLDLYERLVEKYMGKIPASIIASTLVNIIPSLRRDGVPIENIDDYVIEDVLDAVANNEIAKEAIPDVLSSIARNPGKSIKDVIKELGLGVVSISELDELINEAIKKNMDKITAKREKAFQIVMSEVMKSVRGRIDGALVAEKVREKLKEILK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: METK_CLOAB
Sequence: MRKLFTSESVTEGHPDKICDQISDAILDAILEKDPNGRVACETTVTTGIVNVMGEISTNCYVDIPKIVRKTVREIGYTRAKYGFDCDTCAVVTSIDEQSADIAMGVDEALESKKGEMDKIDAVGAGDQGMMFGYATNETKEFMPMPIALAHRLSRRLAEVRKDGTLDYLRPDGKTQVTIEYEDDKPVRVDAIVISTQHGPEIGHEQIEKDLIEKVVKYVISPELLDENTKYYINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGIADKLEIQLAYAIGVAKPVSISVDTFGTGKIEESKIVEIVEKVFDLRPGAIIRDLNLKRPIYRQVAAYGHFGRLDVELPWEQLDRVEAIKKYL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSW_DROME
Sequence: MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT
What is the function of this protein?
Required in all receptor tyrosine kinase signaling pathways.  Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless.  Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor).  The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions.  Maternally required for normal determination of cell fates at the termini of the embryo.  Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration.  Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw.  Dephosphorylates drpr isoform A which is required for the inhibition by drpr isoform A of glial cell engulfment of axonal debris produced following axonal injury (PubMed:22426252).
What are the official names of this protein?
Tyrosine-protein phosphatase corkscrew.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGPA_YERE8
Sequence: MSSSRPGFSCSWLPYLLVLPQLAITAVFFLWPAGEALWYSVQMLDPFGLSSEFVGLSNFIALFHDEYYLASFYTTLIFSSLVAGIGLVVSLFLAAMVDYVLRGSRIYQTLMILPYAVAPAVAAVLWIFLFNPGLGLITHFLASLGYNWNHAQNSGQAMFLVVLASVWKQISYNFLFFLAALQSIPRSLVEAAAIDGAGPVRRFFNLVLPLISPVSFFLLVVNLVYAFFDTFPVIDAATGGGPMQATTTLIYKIYREGFAGLDLSSSAAQSVVLMLLVIGLTVIQFRFVERKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RDM1_HUMAN
Sequence: MAELVPFAVPIESDKTLLVWELSSGPTAEALHHSLFTAFSQFGLLYSVRVFPNAAVAHPGFYAVIKFYSARAAHRAQKACDRKQLFQKSPVKVRLGTRHKAVQHQALALNSSKCQELANYYFGFNGCSKRIIKLQELSDLEERENEDSMVPLPKQSLKFFCALEVVLPSCDCRSPGIGLVEEPMDKVEEGPLSFLMKRKTAQKLAIQKALSDAFQKLLIVVLESGKIAVEYRPSEDIVGVRCEEELHGLIQVPCSPWKQYGQEEEGYLSDFSLEEEEFRLPELD
What is the function of this protein?
May confer resistance to the antitumor agent cisplatin.  Binds to DNA and RNA.
What are the official names of this protein?
RAD52 motif-containing protein 1, RAD52 homolog B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Isoform 3 and isoform 10 are predominantly nuclear and nucleolar. After treatment with proteasomal inhibitors and mild heat-shock stress, isoform 1, isoform 3, isoform 5, isoform 7, isoform 8 and isoform 10 are relocalized to the nucleolus as dot-like or irregular subnuclear structures. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Isoform 3, but not isoform 1 and isoform 5, is relocalized in nucleolar caps during transcriptional arrest. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress.
Protein: Y385_MYCPN
Sequence: MLLKRLIKLAIFLFFVAVGFIIFIGSFWLNTYNTKEWANLLAEKDASGLIVQIIPNINQWFKGTVEQQQKLFQTLVHFFIPVGFGLLFGIAVAIIADLFYHLIKYLIKRSFKKN
What are the official names of this protein?
Uncharacterized protein MG267 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.