PharMolix/UniProtQA huggingface dataset:
Protein: CLU_DICDI
Sequence: MSETIDNPTVEEYNEKETVVSGEQVEQVEQVEQENEQVSQSFQISIKTPAEIGTINIQVQPTDTLIDIQSFLYETSETCLYSSFEFRLYGKQIPEYSELSSIEGLVEGATLEMVPVDYNERSAKLHVKRLRDIMNTGLTEFANMNNPSLFTSFSFPEKSNILTEEQQLEEQKQKFEQQQQQQQQTEDKEEKETIATEQQQNKKNKHHNKKGNKKNNGDESLNNENNEEKLTPQQKERKQKMTEIKGIDKPMLSSYYPESPIAPVQCVKSMIYSGWSPVPGYRKLFGDLFYLDITLLEGTTICVTASTQGFFINQSSNATFNPSVSPKATINHSLHQLLTQVSRLFRRGLNQILTNIGRNHPFDMLPGVLPVHNWVASSKTNRYDINKGTDTFVSVQDVELRGNPRDWNEEIQAPKELPKSTVQERIIRDRAISKVNSEFVECAIRGAQVIVDKAILPINPAENQRSHMFLYNNIFFSYALDTRDSFTDCGGDDAARTSANNDLKGIRLYNLADIDGLYTLGTAIVDYKGQRIIAQSLIPGILTTEKTSKIYYGSMDTPTNEEEEQQQKEENEENKNNNTKSIKADPEFHSRLLQAASLLHLSESKVISEDTNQEVSVCTSFESKGIIGIDGRRYILDLIKATPRDPNYTETKDQLSVLRPEAIATYSEYFKVTWLNQKRQQKLKEKEERQKKEGIDPPTATARDEDVQLTEEDLAQSPVVSFNPNLFSKVKLGGTPEEQQKDIEDLKAIGAFLKGILIPRLIEDLMLFNVAPVDGQTLTQVMHVRGINMRYLGYIAKNESANVPFIQDLLFNEMVSRAAKHCFNRLLRSTNASDMAHSISHFLNCFLGTETGSVSADEKSKKAKQIKSSAINELTQGKLWSEIAQLVSSKFDFEIPTHSVPMESRLIVLRCICLKMGIQILAKDYNFTTDAPFSPEDIVDLFPIVKHVNPRSTDGLDLLEAGKTFFNQRKYELATELLGEALAIYHQVHGPIHPDAGACFTHLAMLAYQNEQYDLAIEYQKNALVITEKTAGLDHHETVQAYTTLAVFCQRSGRYNESIGYMKHVLYLTDLLGGEYNPERASIYTAIAAILEDTERFDLALEFLKQTLKHQEFLFTPDHLMCSTTYHKMAIVCARATNFDDSIIHQKKSTDILEKELGEAHPRTKESLEFYTGLSQTANQIKLFKQHQALKAEQDELARLQKEKADQFKKSQPRVSAMPPSLENGSVSELLNYINGKPKKSQSKKSKSTNTTTTTNTTTATTSKSKITMAKTPNPTTKATTSKSSATASSAATNKSTTKTNPTSSSAADSSKPNKKSSKN
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Clustered mitochondria protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_METMJ
Sequence: MTKIRVLDPDTVNQIAAGEVVERPASVVKELLENAIDADSTSILIDVSSDMAAITKIRVTDNGEGMTPEEAVLAFHPHATSKIRDIADLSAVRTLGFRGEALASIAAVAEVTLVTRPRGGGALAGTRLVVRGGEIVEKSEVGAPEGTTIAVERLFYNTPARRKFLKSRNTELAHVYAVVESLALAHGEVAFRVVHNGKERMATQRSGGALNTIAGLYGADLARSLVPVEGRLPFLAIRGYISRPSESRGNPSQISVSINGRSIASRQIAAAVREGYGTLLPKDRYPVAFLDLAIDTGLVDVNVHPTKREIRLSREREITGAIAAAVDEALAGHDLARETPVEPVQQQIIAADPGQVPTPSPVGEPGAPYTAGHRGLTLSDKQLRRTETEGGENLLPAMEPIGQVAATYIVAEGADGTLYLVDQHAAHERVLYDQVTEQRDKAAGSQELITPVVLSLPPKESAALRDAIPLLADEGFVVDEFGRDTFAVRAVPAALGAVEDPGTVRETIADLLADESRTAPDRRERVTCIVACRGAVKAGALLTPDQQKRLIMQLARTKTPWTCPHGRPTVVAFDRRRLDGMFRRG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ACPS_SOLM1
Sequence: MIRGLGIDVVELDRIEAALIRFGDRFLARILTPAERAALPPIPLTRTAGLFAAKEAAAKALGTGFAQGVAFHTLEILSDAAGRPALTLHGPALARAEALGATSWHVSISHSRDTAAAVVVLEG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_PARDP
Sequence: MRVYYDRDCDVNLIKDKKIAMLGYGSQGHAHALNLRDSGAKNLVVALREGSASAKKAEAEGLKVMGIAEAAAWADLIMFTMPDELQAETYRKYVHDNLREGAAIAFAHGLNVHFGLIEPKPGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQDATGKAMDIGLSYCSAIGGGRSGIIETNFRQECETDLFGEQAVLCGGLVELIRMGFETLVEAGYEPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEYGEYVSGPRVLPYEETKARMKAVLTDIQTGKFVRDFMQENAVGQPFFKATRRINDEHQIEKVGEKLRGMMPWISKGKMVDKERN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PIRL8_ORYSJ
Sequence: MESSPPPPPPTITVQVKFGGRTIPVEVPAAATAADLKRLLQPLTNVLPRGQRLICKGKVLADAASLSSMQVVNGSKVMLMASQGLHQGDGPITKNSSVPAPSTRRASNVKEAQIQKSDTNVSKIRPERWKATGIIALSDSSLKAVPEEVWGCGSSIRVLDVSNNCIEAIPQEIAALRSLQKLILTANDIADGNISWEGLTCVQTLTVLSLSQNRLVTLPSSLGSITHLRELRIANNRLENLPVEIGLLKHLEILIANNNRITSLPSSIGGCESLNEVDLSSNLLAELPEAFGNLQHLKALSVRNNGLTSLPSAFFIKCSQLITLDLHGTEITNDVLRQVDGWEEFDERRRKKHQKQLDFRVGSSVVFDEGADDDYRRL
What is the function of this protein?
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
What are the official names of this protein?
Plant intracellular Ras-group-related LRR protein 8, Intracellular Ras-group-related LRR protein 8, OsIRL8.
What is the protein family that this protein belongs to?
Belongs to the SHOC2 family.
Protein: CYB_CASDU
Sequence: MPHHYILTMFGLLPVATNISTWWNFGSMLLSCLMLQVTTGFFLAVHYTANTNLAFSSIIHIMRDVPYGWMMQNTHAIGASLFFICIYIHIARGLYYGSYLNKKTWMSGTTLLITLMATAFFGYILPWGQMSFWAATVITNLLTAVPYLGTSLTIWLWGGFAINDPTLTRFFALHFILPFIIISLSSLHILLLHEEGSSNPLGTNSDTDKIPFHPYHTYKDLLLLTLLLTLLLLTTFFLPNIMNDPENFSKANPLVTPQHIKPEWYFLFAYGILRSIPNKLGGALALVASILIIMTMPFTHTAHVRSMTFRPMSQLMFWTLISTFMTITWAATKPVEPPFMMISQTASMIYFMFFISNPILGWMENKIMKTM
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACKA_RHIME
Sequence: MEALLVINAGSSSLKFQIFGIATAGLERQVRAKLDGIATQPRLKATAADGTELINRRLDATAVPDLPEALSVARDWLATLRGFDLRAIGHRVVHGGPDYVRPVLIETTVLDRLASYQDLAPLHQPNNLAPIRLAMDIKPDVPQVACFDTAFHRGRTEHTDCYALPRTFYEQGVRRYGFHGISYEYIAGRLREVAPEVARGRVIVAHLGSGASMCALKDGRSVETTMGFTALDGLPMGTRPGQLDPGVVLHLLTDQGMSAQAVSDLLYHRSGLKGLSGISNDMRELLGSDDPRASFAIDHFVHRCALDAGMLAAALGGLDAFVFTAGIGENSAPIRARVSEGLAWLGAELDPAANDAGASVISKAGSRVALHVMPTDEELMIARHTLAIIRAR
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAC_BACVZ
Sequence: MENVFDYEDIQLIPAKCIVDSRSECDTSVTLGGHTFKLPVVPANMQTIIDENIAAWLAENGYFYIMHRFEPEKRLAFVQDMKARGLISSISVGVKENDYEFIRELKAQELVPDYITIDIAHGHSNAVISMIQFIKEHVPESFVIAGNVGTPEAVRELERAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHEESPGQTIEIDGKLYKEYFGSASEFQKGEKKNVEGKKMHVEHKGSLQDTLVEMEQDLQSSISYAGGNTLEAIRNVDYVIVKNSIFNGDRF
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: TR96_PRORE
Sequence: MKTLSERLNHALQLTGVTQSELARRIGIKQQSISQICSGKSARSRYTMQIAEALRVNAHWLATGDGEIGLGVGNVEVGPDIKGRIPLINWVQAGDWTEIAEGFAHEDAEEWREVTGKAHEGCFALRVKGDSMENPSGKKSIPEGAVIVVDPELPYSSGSLVVARLDDSKEATFKQLVIDGEQKYLKPLNPQYPAIPINGNCTIIGVVRQAIIDFW
What is the function of this protein?
May control the expression of the integrase and inhibit excision of the mobile element R391, and regulate the expression of other genes as well.
What are the official names of this protein?
HTH-type transcriptional regulator for conjugative element R391, ORF-96 protein.
Protein: SYS_CHLSY
Sequence: MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIGAMKDPAERQAKIDAMRQLGDEIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDNVVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGSRFYVMRGAGARLQRAVIQWLIDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYADEILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKLRRDAEECARRLGLPFRTKLLCTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQARRANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQEDGSILIPEVLRPYMGGMERIGP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLQ_LACLN
Sequence: MNEDLISQIKEVVTAENQEKLIKIIQLLESSNYELRGKINPDLQLSASALVFKEDKLFFIEHPYQKELLLPAGHVELKESPLDTAIREFHEETGFFAKKMGKLVDVNLIDIPFNETKNEKKHQHIDFRYLLELEEQEAELAELPFFLLELEEAPEEFKKYYRYKNI
What is the function of this protein?
Probably mediates the removal of pyrophosphate from dihydroneopterin triphosphate (DHNTP), a possible step in the pterin branch of the folate synthesis pathway.
What are the official names of this protein?
Probable DHNTP pyrophosphohydrolase, Dihydroneopterin triphosphate pyrophosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: PADI4_RAT
Sequence: MAQGAVIHVAPEEPTHAVCVVGTATPLDIRGSAPRGSTSFSITASPEVVVDVIHGPPSKKSTTGASKWPLDPKLEVTLQMKAASSRIDDQKVRISYYGPKTSSTQALLYLTGVELSLSADVTRTGKAKPAPAGKDQSTWTWGPDGHGAILLVNCDKEDPKSSGMDFEDDKVLDNKDLQDMSPMTLSTKTPKDFFDKYQLVLQVPKAKMNKVRVFRATRGKLPSRYKVVLGPQQFSHRLELLGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDTVMFRVAPWIMTPNTQPPQEVYVCRFSDNEDFLKSLATFTKKAKCKLTVCPEEENQDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRGLYRAEVTGLDAFGNLEVSPPVTVRGKEYPLGRILIGSSGYSSSESRDMHQILQDFLGAQQVQAPVRLFSDWLFVGHVDEFLSFVPARGKQGFRLLLSSPRACYQMFQELQTEGHGEASLFEGLKRKRQTISDILSSQKLRDQNAYVESCIDWNREVLKRELGLTEGDIIDIPQLFRIVGNSRGNPKAEAFFPNMVNMLVLGKHLGIPKPFGPIINGRCCLEEKVCSLLEPLGLHCTFINDFYSYHMYHGEVHCGTNVRRKPFAFKWWHMVP
What is the function of this protein?
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance.  Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci).  Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.  Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (By similarity).  Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).  Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription.  Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity).
What are the official names of this protein?
Protein-arginine deiminase type-4, PAD-R4, Peptidylarginine deiminase IV, Peptidylarginine deiminase type alpha, Protein-arginine deiminase type IV.
What is the protein family that this protein belongs to?
Belongs to the protein arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.
Protein: C74A3_ORYSJ
Sequence: MAPPPVNSGDAAAAATGEKSKLSPSGLPIREIPGGYGVPFFSPLRDRLDYFYFQGAEEYFRSRVARHGGATVLRVNMPPGPFISGNPRVVALLDARSFRVLLDDSMVDKADTLDGTYMPSRALFGGHRPLAFLDAADPRHAKIKRVVMSLAAARMHHVAPAFRAAFAAMFDAVEAGLGAAVEFNKLNMRYMLDFTCAALFGGEPPSKVVGDGAVTKAMAWLAFQLHPIASKVVKPWPLEELLLHTFSLPPFLVRRGYADLKAYFADAAAAVLDDAEKSHTGIPRDELLDNLVFVAIFNAFGGFKIFLPHIVKWLARAGPELHAKLATEVRATVPTGEDDGITLAAVERMPLVKSVVWEALRMNPPVEFQYGHARRDMVVESHDAAYEVRKGEMLFGYQPLATRDEKVFDRAGEFVADRFVAGGAAGDRPLLEHVVWSNGPETRAPSEGNKQCPGKDMVVAVGRLMVAELFRRYDTFAADVVEAPVEPVVTFTSLTRASSG
What is the function of this protein?
Involved in the biosynthesis of jasmonic acid, a growth regulator that is implicated also as a signaling molecule in plant defense.  Converts 13-hydroperoxylinolenic acid to 12,13-epoxylinolenic acid (By similarity).
What are the official names of this protein?
Allene oxide synthase 3, Cytochrome P450 74A3, Hydroperoxide dehydrase 3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: CLS2_STAAR
Sequence: MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGFILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLLYNNAAFLTTDNDLKVYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKKAEQGVEVKILYDDMGSRGLRKKGLHPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVIDGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISYDDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLDSIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDDEIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYAKRSLWIKFKEGISQLLSPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase 2, CL synthase 2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CX3C1_RABIT
Sequence: MTTLYSDWATESFEYDESSEACFIGDIVAFGTIFLSIFYSLVFAFGLVGNLLVVCALTSSRKPKSITDIYLLNLALSDLLFVATLPFWTHYVISEQGFHNAVCKLTTALFFIGFFGGIFFITVISIDRYMAIVLAANSINNRTVQHGVTTSLGVWAAAILVAAPQFMFTKQKGNECLGDYPEVLQDIWPVLRNTEANFLGFLLPVLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYGFFPNCDMKRDLRLALSVTETVAFSHCCLNPLIYAFAGQKFRRYLRHLSRKCQAVLCGRPVHVSFSPSESQRSRQESIVSSNFTHYTSDGDASLLL
What is the function of this protein?
Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis.  CX3CR1-CX3CL1 signaling mediates cell migratory functions.  Responsible for the recruitment of natural killer (NK) cells to inflamed tissues.  Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival.  Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung.  Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells.  Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis.  Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation.  Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli.  Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development.  Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development.  Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.  Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria.  Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C. albicans or C. auris infection (By similarity).  Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity).
What are the official names of this protein?
CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Fractalkine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYE_CLAM3
Sequence: MTETTAHPVTTATGTDVRVRFCPSPTGTPHVGLIRTALFNWAYARHTGGKLVFRVEDTDAARDSEESYEQLIEALRWLEIDWDEGEGVGGPHAPYRQSQRTDLYLDVIRKLTESGHLYESYATAEEIEARNRAAGRDPKMGYDNFERDLTEAERQAFRDEGRSPALRLRVPDTDLSFDDLVRGTVTFPAGSFPDFVLVRPNGAPLYTLVNPVDDALMGITHVLRGEDLLSSTPRQIALYHALIDIGVADAIPRFGHLPYVMGEGNKKLSKRDPESNLFHHRDRGFIPEGLINYLALLGWSLTHDRDVFSRMEMVTAFDVADVTPAPARFDLKKAESLNGDHIRLLALDDFAQRLVPYLQAADVVGAELTHDEQRMLEAAAPLVQERMQLLGEAPDLLSFLFTTADALPYDDAAVQALKDDAAAVLAASRGALAGVPHTQWDIDLVQEVLQNTLITGMGMKPRLAYGPLRVAVSGRRISPPLFESMVLLGKDETIARLDRLAGMLGG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFB4D_ORYSJ
Sequence: MAFLVERCGGEMVVSMERSHGRSTTTAAAVTAAPAPFLSKTYQLVDDPSTDDVVSWGEDEATFVVWRPPEFARDLLPNYFKHNNFSSFVRQLNTYGFRKIVADRWEFANEFFRKGAKHLLSEIHRRKSSSCSQPQPPPPFPMHQHYPLSLFSPPTTPRSPPVGAAAAAAYHFQEEYCSSPADYAGGGGDLLAALSEDNRQLRRRNSLLLSELAHMRKLYNDIIYFLQNHVEPVAPPPLAAATSCRLVELGPSTTERRRCAASPSGDNDDDAAVRLFGVRLDDDHGKKRRVQLVQEDEGDEQGSEG
What is the function of this protein?
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
What are the official names of this protein?
Heat stress transcription factor B-4d, Heat stress transcription factor 10, OsHsf-10.
What is the protein family that this protein belongs to?
Belongs to the HSF family. Class B subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TFP11_XENTR
Sequence: MSMSHLYGKDEDSDGVEMENFEITDWDLQNEFNPNRRKHFQTKEEATYGMWAERDSDDERPSFGGKRSRDYSAPVNFISAGIRKPAAEEKSDSDSDSETQARRETFPKDFEAKKLRTGGNFKPSQRTFAGGIKSNTDFGSWERHTKGIGQKLLQKMGYVQGRGLGKNAQGIIAPIEAKQRKGKGAVGAYGSERTKQSIKDFPVVDSEEEEEKEFQKEMSQWRKDPGGGKKKPKYSYKTVEELKAKGKVGKSLSAPQKEISQVKVIDMTGREQKVYYSYSQLAHKHNIPGEAPGQGAKEEKPQGFALPELEHNLQLLIDMTEQEIIQNDRQLQYEQDMVVNLTHELEKLSEVLEREEKAIQNLSKVLETVEECERRIQPMCDNPLTLEECARIFEMLQDKYYEEYKMSEKADLSVAIVYPLMKDYFKDWNPLRDPTYGTDVMSKWKNLLEEGHLLSHSAHDASMDPYHRLLWETWVPLLRSIIAQWQPRNCAPMVDFLDCWVHLLPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQSRLEPLFSPIRNKLANALQKWHPSDSSAKLILQPWKEVFTPGSWEAFMVKNILPKLGMCLSEFVINPHQQHMEVFHWVTDWEGMVSLSSIVGILEKHFFPKWLQVLCSWLSNNPNYEEITKWYLGWKSMFSDLVLAHPAIKDKFNEALDIMNRAVSSSVGAYMQPGARESIAYLTQTERRKDFQYEAMQERRDAESIAQRGIGAAAAVPMNFKDLIQSKAEEHNIVFMPLIGKRHEGKQLYNFNRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK
What is the function of this protein?
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
What are the official names of this protein?
Tuftelin-interacting protein 11, Septin and tuftelin-interacting protein 1, STIP-1.
What is the protein family that this protein belongs to?
Belongs to the TFP11/STIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOB_LEPBA
Sequence: MHTRMQIRNRVNFGKITDLNLLPNLIYVQKKSFDWFLQSEVKDPTKRLNQGLEAVFRESFPIESPNNDMVMEYGHYVLGEPKRDPQECKDTDSSFAVPLKAVIRLIIKDTGEIREQVVYMGDLPVMTDHGTFIINGAERVVVSQLHRSPGIFFSYDQVRDTFSARVIPYRGSWLEFEMDNKGILVAKIDRKKNFPATLLVKAMGMGTNEEVLRLFYGSSKMKIAGANPKDLKRLIGRRTIADIINMETGEVMLDAGSKINEDNISILREMKVKEVDVIEFPKGKDNPVLINCLEKDGVNDYEDAVKKFHTIMRPGEPSTIENAEAELKRLFFSPKTFDLGIVGRYKINSKFEFNNPKEFSKADDRVLRKQDIIETVRYLVMLMSEAENYYPDDIDHLGNRRIRSVGELIANQLKLGFSRVERVIKERMTVQEPEQQTPQLLISIKPITAVINEFFGSSQLSQFMDQTNPLAELTHKRRLNALGPGGLSRDRAGFEVRDVHYSHYGRMCPIETPEGPNIGLILSMSSFARVNDYGFIETPYRLVKNGKVQKQVEYLTADKEEYHYMAQSNSTVDEKGEFTSKLISTRHRGDFPFRSPAEIQYMDLAPLQVVSVSTALIPFLEHDDANRALMGSNMQRQAVPLLTEEAPFVGTGMEARAAYDAGVCIVAKKDGVVSKVDATGVWIKEDQSKEIVHYPLIKFKKTNQGTCFNQKPNVSMLHTTTGGKVSKVSKERVEVTTPNGEKETHELLLSDEVQFHAVVKEGQEVGIGAPVAGQIIKGEKYGDFGQILQKGTVLANGPSTDAGYLALGRNVLVAFMPWEGYNFEDAILISERIIKDDVFSSIHIEEFEIQARETKLGQEQITRDIPNLSDKAFRDLDESGVIRVGAEVKPGDILVGMVTPKGETDLTPEYKLLHSIFGEKAKEVRDSSLRMPNGFEGTVIDIKRYSRETGDELAAGVEEMVKVYVARKRKLLVGDKMAGRHGNKGVVARVMAQEDMPYMEDGSPVDIVLNPLGVPSRMNLGQIFETQLGFAAKKLGINFETPVFDGASEGDVNDFCKKAGLPENSKFQLYDGRTGEKFINQVFCGYIYMLKLAHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGASHTLQELLTIKSDDMLGRARIYEAIVKGIHSIKPGIPESFNVLVQELRGLALDIIIKDSEGLEVDISDYEDEFSKNKKKIKFETIENV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PSBF_SACHY
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: QUEC_CLOK1
Sequence: MKKAVVLLSGGLDSTTVLYLAKSQGYEVYAMSFDYGQRHKKEIQCARDVASGTGAADFVLVTTNMNAWGGSALTDNSIKVPEFNEESEKIPVTYVPARNMIFLSYAASYAETIGAYDIFIGVSEVDYSGYVDCRHEFIDSMEKTINLGTVCAVEHKKYIKIHAPFLYKTKSEEIKIGMDLGVKYEKTWTCYNGEEFACGICDSCRLRLEAFKEAGYKDPIKYKGEK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.