PharMolix/UniProtQA huggingface dataset:
Protein: RSMF_ECOSM
Sequence: MAQHTVYFPDAFLTQMREAMPSTLSFDDFLAACQRPLRRSIRVNTLKISVADFLQLTAPYGWTLTPIPWCEEGFWIERDDEDALPLGSTAEHLSGLFYIQEASSMLPVAALFADGNAPQRVMDVAAAPGSKTTQIAARMNNEGAILANEFSASRVKVLHANISRCGISNVALTHFDGRVFGAAVPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNQEIAATQRELIDSAFHALRPGGTLVYSTCTLNREENEAVCLWLKETYPDAVEFLPLGDLFPGANKALTEEGFLHVFPQIYDCEGFFVARLRKTQAIPVLPAPKYKVGNFPFSPVKDREAGQIRQAAAGVGLNWDGNLRLWQRDKELWLFPVGIEALIGKVRFSRLGIKLAETHNKGYRWQHEAVIALASPDNVNAFELTPQEAEEWYRGRDVYPQAAPVADDVLVTFQHQPIGLAKRIGSRLKNSYPRELVRDGKLFTGNA
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRTA_MYCBO
Sequence: MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR
What is the function of this protein?
Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT).  Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell.  Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
Mycobactin import ATP-binding/permease protein IrtA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMA_HALOH
Sequence: MDKVIATPGGTNEIIRKYNLKLHKGLGQNFLIDQNIVDKIINTADLNNEDIVIEIGPGIGSLTQKIVPRSGRVFAFEKDKRLVKVLRELFNGYNHLEVIGQDVLEVDWKHFFDSRGISDRSVKVLANLPYYITTPVIMGLLESNITFSLMVLMVQKEVADRMAAAPGSKDYGALSVAVQYYGEVEIFHKVPPTVFIPRPRVYSSIIKIKPHSEPVYRVKNEGFFFKMVRAIFQQRRKTLKNSLTKSSEIKLDKGIVTEAIRELGLDPRIRGEKLTIKQMAILSNTLWYKISEEDGENHEIY
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL34_HUMAN
Sequence: MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP
What is the function of this protein?
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages.  Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes.  Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption.  Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
What are the official names of this protein?
Interleukin-34, IL-34.
What is the protein family that this protein belongs to?
Belongs to the IL-34 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPF_BIFLO
Sequence: MMTQAASGIDLFIPEVYDIVWSLIILVIVAVFFYKFFMPKFNAIFDERAAKIQGNIAKAEQARKDADEAKAKYEAQLSTARVDAAKIRDDARAEASHIIADARSRAESDAAQITASAQRSIESQHQQAIVSLKGEVGALATALAGKILGAKLEDNDVQSSMIDSMIDDLGAKK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HTPX_SALA4
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLLIMALLFGFGGSFISLLMSKWMALKSVGGEVIEQPRNERERWLMNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRIIAQIAAGFLGGNRDEGEGSNGNPLIYFAVATVLELVFGILASIITMWFSRYREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRSGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA_BACP2
Sequence: MSIKAEEISALIKQQIQNYQSEIEVKDVGTVIQVGDGIARVHGLDNIMAGELVEFSNGVMGMAQNLEESNVGIVILGPYKDIREGDDVKRTGRIMEVPVGEELIGRIVNPLGQPVDGLGPILTSKTRPIESEAPGVMDRKSVHEPLQTGIKAIDALIPIGRGQRELIIGDRQTGKTSVAIDTILNQKDQDMICIYVAIGQKESTVRGVVETLRKHGALDYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGGGSITALPFVETQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAVNAGLSVSRVGGSAQIKAMKKVAGTLRLDLASYRELEAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLKVEKQVAILYALTRGYLDDVAVADVKRFEAELFMYIEENHKGLFDTISQTGNMPADEEWNTAIEGFKRTFAPSN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CXL13_HUMAN
Sequence: MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP
What is the function of this protein?
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils.  Does not induce calcium release in B-lymphocytes.  Binds to BLR1/CXCR5.
What are the official names of this protein?
C-X-C motif chemokine 13, Angie, B cell-attracting chemokine 1, BCA-1, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSD_RHIL3
Sequence: MPDSRPDTELSNPQSAKAPLDPHLKALENESIHIFREVAAEFERPVMLYSIGKDSSVLLHLARKAFYPGRVPFPLLHVNTGWKFSEMIAFRDETAKKYDLDLIEHINPRGKAENITPFTHGSAAFTDIMKTEGLRQALDAGQFDAAFGGARRDEEASRAKERIYSFRTPDHRWDPRNQRPELWNIYNGMIRKGESVRAFPLSNWTEVDIWRYIQAEDIPLVPLYYAKKRPFVERDGMMILAEDPRLELLPGEVRQEGMIRFRTLGDFPLTGAIRSQATTLEEVIAELEIATVSERQGRAIDRDQSGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: M1_I35A3
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKIKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSERAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: RS10_BURMA
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RT28_BOVIN
Sequence: MAALCRTRAVTAESHFLRVFLFSRSCRGAGTESGSGSESSNSTEPRPRPGGFASALERHSELQRKAELARTRGSPKNVESFASMLRHSPLTQMGPAKDKIVIGRIFHIVENDLYIDFGGKFHCVCKRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTILEAEAVLLGLQESKDSKSKEERRENK
What are the official names of this protein?
28S ribosomal protein S28, mitochondrial, MRP-S28, S28mt.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VE6_HPV6B
Sequence: MESANASTSATTIDQLCKTFNLSMHTLQINCVFCKNALTTAEIYSYAYKHLKVLFRGGYPYAACACCLEFHGKINQYRHFDYAGYATTVEEETKQDILDVLIRCYLCHKPLCEVEKVKHILTKARFIKLNCTWKGRCLHCWTTCMEDMLP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: HEM6_FRAP2
Sequence: MQEKITQFENFLAQLQQKITSTLEQSETSSAKFISDKWQKPDTPEQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGDALPPSATAKRQELAGKSFIATGVSLVIHPRNPFVPTSHANFRIFVAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDASYYPSFKKLCDEYFYLKHRDECRGVGGLFFDDLNDKSFDECFKFVTDCANSYLDAYIPIVEKRKNIEYSQKHKDFQLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYEYIKPRDWIK
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_ECO5E
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFNEMQPVEETQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MRAY_ECO45
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGJ_NEIMA
Sequence: MAVNLTEKTAEQLPDIDGIALYTAQAGVKKPGHTDLTLIAVAAGSTVGAVFTTNRFCAAPVHIAKSHLFDEDGVRALVINTGNANAGTGAQGRIDALAVCAAAARQIGCKPNQVLPFSTGVILEPLPADKIIAALPKMQPAFWNEAARAIMTTDTVPKAASREGKVGDKHTVRATGIAKGSGMIHPNMATMLGFIATDAKVSQPVLQLMTQEIADETFNTITVDGDTSTNDSFVIIATGKNSQSEIDNIADPRYAQLKELLCSLALELAQAIVRDGEGATKFITVRVENAKTRDEARQAAYAVARSPLVKTAFFASDPNLGRLLAAIGYAGVADLDTDLVEMYLDDILVAEHGGRAASYTEAQGQAVMSKAEITVRIKLHRGQAAATVYTCDLSHGYVSINADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_PELUB
Sequence: MKITTAWLKDHLDTKLNENQIIDKLTDIGLEVEGVDSQSGELDQFVIAKILKAEKHPDADRLRVCDVDIGSGKSVKVVCGAPNAKEGLLTIYAPPGAVVPKSQMKLVVSKIRGVTSYGMLCSESELNLSNESDGITELLPEKYNKKVGENYFPKKNLNVIDISITPNRADCLGVRGIARDLAAAGAGRLINQKEKKLDKKNKQTISVKIENEKNQACISFGSCLIKGVKNTESPEWLKDKIIALGQKPISAIVDITNYIMFDLNRPLHAYDVDKIDKAIVVRNSKKGETFEALDNKEYKLEDEMCVISDASGVLGLGGIIGGTRTGTELDTKNVLIESAYFSPRSIRKSSKILNIDTDAKFRFERGIDPLSIDQGLERAANLIQEICGGEVSEFDIQKIEDVKKKSLKFDPSLFEKITGFNIDIKEMIKILDNLGFEIKENKGILDAVIPSWRPDISQEVDVVEELVRIKGYDQIKIIEPEKVRKKQTLNLKQKLFHFLQRSIASKGYFEAITWSFTDSKINQLFIENNKEIKIINPISSDLNVLRSSIFSNLIIHLNKNLGRGFKDLSFFEIGPTFLGSEPGEQQTVATGLRSGKLARQSWLEKERLIDVFDVKSDVIKSLVEAGYNKDKLYIDDEAPSYYHPGKSGRIFLNKGKEKVVAFFGDIHPGILKKLDIKVESLVGFEIFLDNLKQPKKSLKDQKTQYKYSDFQKSERDFAFVLDKNFKVQELIETISNVDKELIKSVKVFDVYEGANIPEGKKSIALNVIIQPLEKTLTEDDLNKINQLIISAVESKTGAKIRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_COXBR
Sequence: MSVEKQTAMRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTIKSRKAARHATSDWMELEKQRGISVTTSVMQFPYKDYLINLLDTPGHADFTEDTYRTLTAVDSALMVIDAAKGVEPRTIKLMEVCRLRHTPIMTFINKMDRDTRPSIELLDEIESILRIHCAPVTWPIGMGKYFKGIYHLIEDAIYLYQPGKHERVGESERIEGINNPELDKKLGDLASELRNEIELVKGASHPFEREGYLKGELTPIFFGSAINNFGVGELLDAFVKEAPPPQGRETNSRLVKPEEEKFSGFVFKIQANMDPGHRDRIAFLRIASGQYQKGMKAYHVRLKKEIQINNALTFMAGKRENAEEAWPGDIIGLHNHGTIQIGDTFTQGERFKFTGIPNFASELFRLVRLKDPLKQKALLKGLTQLSEEGATQLFRPLDSNELILGAVGLLQFDVVAYRLENEYNVKCVYESVNVVTARWVICDDKAVLERFNQEQSRNLAYDGGGHLTYLAPSRVNLEITMEKWPEIQFSETREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHBS_ECOL6
Sequence: MLIRVEIPIDAPGIDALLRRSFESDAEAKLVHDLREDGFLTLGLVATDDEGQVIGYVAFSPVDVQGEDLQWVGMAPLAVDEKYRGQGLARQLVYEGLDSLNEFGYAAVVTLGDPALYSRFGFELAAHHDLRCRWPGTESAFQVHRLADDALNGVTGLVEYHEHFNRF
What are the official names of this protein?
Uncharacterized N-acetyltransferase YhbS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: VSX2_ORYLA
Sequence: MTGKQGVALSESLNPAEKTSLVINGGSLQPKISATNPPPRCTGFGIQEILGLNKEPATAPRSPLSALPAGAHLIAARSVLGPAGVGVGMGLIGPAGIPSFYSQPAFLETVLADGHDVRLQPHNRSARPLDANQSVSSDSEDLSSSERKLSKSSVNQSKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSTVMAEYGLYGAMVRHSIPLPESILKSAKDGIMESCAPWLLVQDGLPINRRYSKSEYPQLFAGMHKKSMEAANLPATAKCDAPQQPSAQRSEDVEAEEKRSDGKSTISKEEMRENSIAALRAKAQEHSAKVLGTVSPGKLLEGKQEKQAVGEKVSEPPSPTEEQKSP
What is the function of this protein?
Acts as a transcriptional regulator (By similarity).  Mediates the differentiation of V2a interneurons (By similarity).  Plays a role in eye development and organization of the neuroretina (By similarity).
What are the official names of this protein?
Visual system homeobox 2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10, Transcription factor VSX2.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPY1_BOVIN
Sequence: MDPQNQHGSGSSLVVIQQPALDNRQRLDYEREIQPAAILSLDQIKAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRPTSHLGHAGLSNNTRGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPIPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSQCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRGCYDWIHRPGCRCKNSNTVYCKLESCPSRGLGKPS
What is the function of this protein?
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
What are the official names of this protein?
Protein sprouty homolog 1, Spry-1.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
Protein: METK_PORGI
Sequence: MSYLFTSESVSEGHPDKVSDQISDAILDQFLATDPDSKVACETLVTTGQVVLAGEVKSRSYVDVQETARRVIERIGYTKSEYGFDTRSCGIFSSIHEQSADINRGVDRSDRSEQGAGDQGMMFGYATNETENYMPLTVDLAHHLLYELAAIRKEPSSPMPYLRPDAKSQVTIEHDDEGRPVRIDTIVISTQHDEFVQASDGISEAEADRMMQERIHHDIATILIPRVKMLYKPEIAALFDEKVRLFVNPTGKFVIGGPHGDTGLTGRKIIVDTYGGRASHGGGAFSGKDPSKVDRSAAYAARHIAKNMVAAGVADEMLVQVAYAIGVAEPVSIYVNTKGRSHVALSDGQIAEKIKKIFDMRPYAIEQRLKLRNPIYEETAAYGHFGREPYEAYKTFVDEHGTEQMRIVELFTWEKLDYVDKIRAEFGLS
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNU_XANAC
Sequence: MTDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLDQWGALAVEGHFTGPTQWLTYHQLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTAERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEADEPNGTVSMSAIAEAIAQHGPHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVWCHYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQAGMAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRGCQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAPVPLYNRFSDLHTFVEQVEAWAAA
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: PSA_METMA
Sequence: MQMAPQMGYDRAITVFSPDGRLFQVEYAREAVKRGTTAVGIKAADGVVLLVDKRITSRLVEAESIEKIFQIDDHIGAATSGLVADARSLVDRARVEAQVNRVSYDELIGVEVISKKICDHKQTYTQYGGVRPYGTALLIAGVDDNKPRLFETDPSGALLEYKATAIGAGRNAVVEVFEADYREDMNIDAAILLGMDALYKAAEGKFDAGTLEVGVVSLEDKKFRKLGPEEVENYVHQILEKHKGNENKE
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PsmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_CLOPS
Sequence: MDNKLTHFDNKGNAVMVDVSNKNETERIAIATGTVKASSETIELIKSDQIGKGDVLGVARVAGIMAMKNTSNLIPMCHPVMITGSSIDFEIDSEKNEIRITATSKVVHKTGVEMEALTGVSIAALTIYDMCKAVDKRMVIGDIHLVKKLGGKSGEFNF
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.