PharMolix/UniProtQA huggingface dataset:
Protein: SHRPN_RAT
Sequence: MSPPAGGAAAAADPASPVVLLAVQAAVRLLGAGHEDEAQLRKLQLKADPERPGRFRLGLLGIEPGAVSLEWPLESICYTIRGPNQHELQPPPGGPGTFSVHFLNSEEAQQWAALVRDATAEGQNGNDSTAPVPTPAMCPTSPPCSSVTPTPKATQPEMDLPQGSGNLKKEELATHLAQAIAGGDEKAAAQVAAILAQHHVALNVQLLEAWFPRGPIRLQVTVEDATSVLSSSSSAHVSLQIHPHCSIAALQEQVFSEFGFPPAVQRWVIGRCLCMPERSLASYGVSQDGDPAFLYLLSAPREVSGHSPQHSKMDRKLGCLFPQSLELPHNLQASSSSLPSPPQPGWSCPSCTFINASNRPGCEMCSTQRPCAWDPLTATST
What is the function of this protein?
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.  LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.  Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.  LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.  The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria.  LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin.  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation.  Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
What are the official names of this protein?
Sharpin, Shank-associated RH domain-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.
Protein: KN7K_ORYSJ
Sequence: MSSRPSSSASSRRSSSPFSAGSRRPPTSSSSSAGSYLTGRLMPRSYSTASSVSSSSHFFGGGGGSGGGSRSTTPGRRGSSSSSLVGPVPSPPSPVPFPSAEELVIEDTSRSGDSISVTIRFRPLSEREIQRGDEISWYADGERLVRCEYNPATAYGYDRVFGPKTTTEAVYDVAARPVVKGAMEGINGTVFAYGVTSSGKTHTMHGDQNCPGIIPLAIKDVFSLIQDTPGREFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGTYVEGIKEEVVLSPGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGDEYDGVMYSQLNLIDLAGSESSKTETTGLRRREGSYINKSLLTLGTVIGKLSEGRATHIPYRDSKLTRLLQSSLSGHGHVSLICTITPASSNMEETHNTLKFASRAKRVEIYAARNRMIDEKSLIKKYQREISSLKQELDQLRRGLIGGASQEEIMILRQQLEEGQVKMQSRLEEEEEAKAALMSRIQRLTKLILVSTKNNIPALTDTSSHQRHNSVNEEDKVSTSQDSSMLVQNDSATKDSLSSASPDAVDEINQLRCASGDHSSIAGSGPDEMQGGITASDQMDLLIEQVKMLAGEIAFGTSSLKRLIEQSIEDPEGTKNQIDNLEREIREKRRHMRALEQKLMESGEASVANASMMDMQQTITKLTAQCSEKAFELELRSADNRVLQEQLQQKNVEINELQEKVLRLEQQLTTNTEASPEQCTEHELHDLKSKLQLKEAESEKLKYEHMKITEENRELVNQNSTLCEEVAYAKELASSAAVELKNLAEEVTKLSVQNAKQAKELLIAQELAHSRVPGRKGRSAGRGRDEVGTWSLDLEDMKMELQARKQREAALEAALAEKEHLEEEYKKKFDEAKKKELSLENDLAGMWVLVAKLKRGALGISDLNVDDRSINLADITNGTKENKADKNVAVVEKQLSDNTVKSLTAEEYRNPEFEPLLVRLKAKIQEMKEKETDSLGDKDGNSHVCKVCFESATAAVLLPCRHFCLCKPCSLACSECPLCRTRIADRIITFT
What are the official names of this protein?
Kinesin-like protein KIN-7K, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-7 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLYA_STRPF
Sequence: MTMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAESYPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEAILEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_SALSV
Sequence: MLIKLLTKVFGSRNDRTLRRMRKAVSLINAMEPEMEKLSDDELKAKTNEFRARIEKGESVESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKKVNKIIPHLIRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPGNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTANGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHANEAGIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALEAPTEEQIAQIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSDTINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLELPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEMQRREEAERLAQMQQLSHQDDDTAVAADLAAQTGERKIGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MUTL_BACTN
Sequence: MSDIIHLLPDSVANQIAAGEVIQRPASVIKELVENAIDADAQNIHVLVTDAGKTCIQIIDDGKGMSETDARLSFERHATSKIREAADLFALRTMGFRGEALASIAAVAQVELKTRLESEELGTKLVIAGSKVESQEAVSCSKGSNFSVKNLFFNVPARRKFLKANSTELSNILAEFERIALVHPEVAFSLYSNDSELFNLPVSPLRQRILAIFGKKLNQQLLNIEVNTTMVKISGYIAKPETARKKGAHQYFFVNGRYMRHPYFHKAVMEAYEQLIPVGEQVSYFIYFEVDPANIDVNIHPTKTEIKFENEQAIWQILSASVKESLGKFSAIPSIDFDTEDMPDIPAFEQNLPPAPPKIHYNSDFNPFKVSSGGSGGGSYSRPKVEWEGLYGGLTKASKMNEPQQEPEMDWENSPFEEEPMVAEEKTISAVSAASSTFSSASSTLYANESVIEKGNLHLQFKGRFILTSVKSGLMLIDQHRAHIRVLFDRYMVQIKQKQGVSQGVLFPEILQLPASEAAVLQGIMDDLSAVGFDLSDLGGGSYAINGIPSGIEGLNPVELVRNMLHTAMEKGNDVKEEIQNILALTLARAAAIVYGQVLSNEEMVSLVDSLFACPSPNYTPDGKTVLTTIKEEDIEKLFK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RBFA_CHESB
Sequence: MPSSAPSQRQLRVGEQARHALSDVLQREDMRDPALEGAVISVSEVRMSPDLKIATVFVSPLSGDKEAIIAALNRHARYIRGRVSPALRQMKYMPEFRFHLDTSYENFEKIDRILRSPEVARDLGDADDEDDNG
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK5_PLETE
Sequence: MKINRLKKYYLQTIVPKLIEQFAYKNQMQVPRLEKIVINRGIGDASQNAKVLESSLKELTIIAGQKGIITRSKKAIAGFKLRQNLPVGVCVTLRGERMYSFLDRLINLALPRIRDFRGMSVESFDGQGNYSLGVEEQLMFPEIVYDKIEQITGMDISIVTSSKTNDEAHALLKEFGMPFKAKGNKN
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPE_ALIF1
Sequence: MAAMTFHLDVVSAEKKLFSGLVETIQVTGSEGELGIFHGHTPLLTAITPGMVRIVKQHGHEEIIYVSGGIVEVQPGSATVLADTAIRGEDLDAAKAEEAKRKAEENIQNQHGDINFAQAASDLAKAIAQLRVIELTKRSR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CSPLX_ARATH
Sequence: MRDNNNNNTREEERSSSSKQQQPQAPMSLKIIDSCLRLSVVPLSVATIWLTVTNHESNPDYGNLEYNSIMGLKYMVGVSAISAIYALLSTVSSWVTCLVSKAWLFFIPDQVLAYVMTTSVAGATEIVYLLNKGDKIVTWSEMCSSYPHYCSKLTIALGLHVFVLFFFLFLSVISAYRAFSPFDPPCDSQTNNDA
What are the official names of this protein?
CASP-like protein 2D1, AtCASPL2D1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HS904_HUMAN
Sequence: MESLTDPSKLDSGKEPHISLIPNKQDRTLTIVDTGIGMTKADLINNLGTITKSETKVFMEVLQAGADISMIGQFSVGFYSAYSVAEKVTVITKHNNDEQYAWESSLRGSFTEYREFYKSLTINWEDYLAVKHFSVEGQLEFRAFLFVPRLAPFELLETRKKKNKIKLSARRDLIMDNCEELIPEYLNFIRGVVDSEDLPLNIFRETKDQVANSTIVQRLWKHGLEVIYTIEPIDEYCVQQLKEFEGKTLVSVTKEDLELPEDEEEKKKQEEGKQKTKQKKNQSLRTSAKSTYGWTANMERIMKAQALRDNSTTGYMAAKKHLEINPDHSFIDTLRQKAETDKNDKSVKDLVILLYETALLSSDFGLEGPQTHANRIYRMNKLGLGTDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEK
What is the function of this protein?
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
What are the official names of this protein?
Putative heat shock protein HSP 90-alpha A4, Heat shock 90 kDa protein 1 alpha-like 2, Heat shock protein 90-alpha D, Heat shock protein 90Ad.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOC_ENTLS
Sequence: MPPVDKQAVAAAFGRAAPHYQQHNELQRRSADALMARLPARRFARVLDAGCGPGGISRYWRDNGCEVTALDLSAQMLAEARRQQAADHYVQADIEAIPLASAQFDLVWSNLAVQWCDSLQDAVQELYRMLRPGGVLAFTTLAADSLPELRQAWRAIDEKPHANRFLSREALDSALSGLRGEFALQTLSVPFADALSAMRSLKGIGATHLHEGRASRTLTRSRLQQLQLAWPKQQGACPLTYHIFTGVMTRD
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RL20_MESHJ
Sequence: MRVKGGSITRQRRRRWLKLAKGYWGHKSIGFKTAKQAVVKSWTYAFRDRKQRKRDFRKLWISRINAAARNQGISYSQLMHKIKQSNIEINRKMLAEMAIHHQSDFENIVKLAIAKSA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ATG17_MAGO7
Sequence: MPSSSSARSSQSLRSSAAAAVSTSSGAADQPSVPIEILVEHLLAAKRSLSSMTLVLEANDLTTQARSVHEDSVVLAARTAFLRAGIAQQIHTLERIRRGLARTYDVGRRDFEQLIKVLDDAGERLTRTMNVLHNTIVDPVFRPAGEEPRSLMFFVDEGNVDRLTKSLKESIAELKAAETSYDGDLLRFDNDIRSVKKHLLAAPGLPSPSNSVFSRPMADLVRTLTNHSHAMAENLSSLTRHFDLCVTAVRASEGGAALALRKAAEDGPSTISISGVIRGDGTDADDQDIKTMSARERDEMLRVVMQDATEVGEVVRDINSGLEEMQALGALVEQQAAHVRTAHECTLDAFRRLEEVEARLGSYVAAEREYVDRCEVEKDAIHERLAQAEDLVVFYEGYAGAYDGLVLEYERRRNVEDKIRALWRKAAAAVEKLEEQDAAARDSMRKDVGDYIPGDLWVGMDDPVRKWKVVAVDEGEGGSGEIEGSSVRLKKGTVEAARERVHGR
What is the function of this protein?
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation.  Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles.  Plays particularly a role in pexophagy and nucleophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 17.
What is the protein family that this protein belongs to?
Belongs to the ATG17 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: RFNG_HUMAN
Sequence: MSRARGALCRACLALAAALAALLLLPLPLPRAPAPARTPAPAPRAPPSRPAAPSLRPDDVFIAVKTTRKNHGPRLRLLLRTWISRARQQTFIFTDGDDPELELQGGDRVINTNCSAVRTRQALCCKMSVEYDKFIESGRKWFCHVDDDNYVNARSLLHLLSSFSPSQDVYLGRPSLDHPIEATERVQGGRTVTTVKFWFATGGAGFCLSRGLALKMSPWASLGSFMSTAEQVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQRLPPDTLLQQVTLSHGGPENPHNVVNVAGGFSLHQDPTRFKSIHCLLYPDTDWCPRQKQGAPTSR
What is the function of this protein?
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules.  Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1.  May be involved in limb formation and in neurogenesis.
What are the official names of this protein?
Beta-1,3-N-acetylglucosaminyltransferase radical fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: DCD_HELPS
Sequence: MGLKADSWIKKMSLEHGMISPFCEKQIGKDVISYGLSSYGYDIRVGSEFMLFDNKNALIDPKNFDPNNTTKIDASKEGFFILPANAFALAHTIEYFKMPKDTLAICLGKSTYARCGIIVNVTPFEPEFEGYITIEISNTTNLPAKVYANEGIAQVVFLQGDEVCEQSYKDRGGKYQGQVGITLPKILK
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: ITP_VZVD
Sequence: MEEPICYDTQKLLDDLSNLKVQEADNERPWSPEKTEIARVKVVKFLRSTQKIPAKHFIQIWEPLHSNICFVYSNTFLAEAAFTAENLPGLLFWRLDLDWTIEEPGNSLKILTQLSSVVQDSETLHRLSANKLRTSSKFGPVSIHFIITDWINMYEVALKDATTAIESPFTHARIGMLESAIAALTQHKFAIIYDMPFVQEGIRVLTQYAGWLLPFNVMWNQIQNSSLTPLTRALFIICMIDEYLTETPVHSISELFADTVNLIKDEAFVSIEEAVTNPRTVHESRISSALAYRDPYVFETSPGMLARRLRLDNGIWESNLLSLSTPGIHIEALLHLLNSDPEAETTSGSNVAEHTRGIWEKVQASTSPSMLISTLAESGFTRFSCKLLRRFIAHHTLAGFIHGSVVADEHITDFQQTLGCLALVGGLAYQLVETYAPTTEYVLTYTRTVNETEKRYETLLPALGLPPGGLGQIMRRCFAPRPLIESIQATRVILLNEISHAEARETTYFKQTHNQSSGALLPQAGQSAVREAVLTWFDLRMDSRWGITPPVDVGMTPPICVDPPATGLEAVMITEALKIAYPTEYNRSSVFVEPSFVPYIIATSTLDALSATIALSFDTRGIQQALSILQWARDYGSGTVPNADGYRTKLSALITILEPFTRTHPPVLLPSHVSTIDSLICELHRTVGIAVDLLPQHVRPLVPDRPSITNSVFLATLYYDELYGRWTRLDKTSQALVENFTSNALVVSRYMLMLQKFFACRFYPTPDLQAVGICNPKVERDEQFGVWRLNDLADAVGHIVGTIQGIRTQMRVGISSLRTIMADASSALRECENLMTKTSTSAIGPLFSTMASRYARFTQDQMDILMRVDKLTTGENIPGLANVEIFLNRWERIATACRHATAVPSAESIATVCNELRRGLKNIQEDRVNAPTSYMSHARNLEDHKAAVSFVMDSRQQFIVDSGPQMGAVLTSQCNIGTWENVNATFLHDNVKITTTVRDVISEAPTLIIGQRWLRPDEILSNVDLRLGVPGNTSGSDP
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: RL28_YERPG
Sequence: MSRVCQVTGKRPMSGNNRSHAMNATKRRFLPNLHSHRFWVEGEKRFVTLRVSAKGMRVIDKKGIETVLAEIRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SLB_MACLB
Sequence: ALNCASGWSGGYDQHCYKVFDIPPSWAADEKFCKQQTSGGHLV
What is the function of this protein?
Binds to the platelet GPIb/IX/V receptor system and inhibits ristocetin-induced platelet aggregation in human platelet-rich plasma.  Strongly inhibits platelet aggregation induced by ADP, calcium ionophore, thrombin and collagen.  Does not inhibit U46619-induced platelet aggregation.
What are the official names of this protein?
Snaclec lebecetin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL362_ECOUT
Sequence: MKVLNSLRTAKERHPDCQIVKRKGRLYVICKSNPRFKAVQGRKKKR
What are the official names of this protein?
50S ribosomal protein L36 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: FOLD_SYMTH
Sequence: MTAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKELGMHSVLYHLPATTTQQELADLVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVDGFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKHAVVVGRSNIVGKPMAALLLQRHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKRIRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FL2D_MOUSE
Sequence: MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTSSEPVDQAEVTSKDCSRLANGPSNGSSSRQRTSGSGFHREGSTPEDDFPSSSGNGNKASNSSEERTGRGGSSYINPLSAGYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGAVL
What is the function of this protein?
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716).  Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716).  Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity).  Acts as a mRNA splicing regulator (By similarity).  Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity).  Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing regulator WTAP, Female-lethal(2)D homolog, WT1-associated protein, Wilms tumor 1-associating protein.
What is the protein family that this protein belongs to?
Belongs to the fl(2)d family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716).
Protein: GCA1_ARATH
Sequence: MGTLGRAFYSVGFWIRETGQALDRLGCRLQGKNYFREQLSRHRTLMNVFDKAPIVDKEAFVAPSASVIGDVHIGRGSSIWYGCVLRGDVNTVSVGSGTNIQDNSLVHVAKSNLSGKVHPTIIGDNVTIGHSAVLHGCTVEDETFIGMGATLLDGVVVEKHGMVAAGALVRQNTRIPSGEVWGGNPARFLRKLTDEEIAFISQSATNYSNLAQAHAAENAKPLNVIEFEKVLRKKHALKDEEYDSMLGIVRETPPELNLPNNILPDKETKRPSNVN
What is the function of this protein?
Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide.  Mediates complex I assembly in mitochondria and respiration (By similarity).
What are the official names of this protein?
Gamma carbonic anhydrase 1, mitochondrial, AtCA1, GAMMA CA1.
What is the protein family that this protein belongs to?
Belongs to the gamma-class carbonic anhydrase family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Peripheral membrane protein; Matrix side. Note=Probably integral to the membrane.
Protein: Y1911_DESOH
Sequence: MHRKNLLNIGFGNRIVAEDIIAVVSPASAPVKRMKDEAKKAGRLVDATQGRKTRSVIVMASNHVILSAIHTETISQRFAAINGNRLGPDDDPDLMPE
What are the official names of this protein?
Putative regulatory protein Dole_1911.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: IBOG1_AMAMK
Sequence: MAIYQVIPYGLPVPPNTPHAILVSLPTWNDTVTCIEGEDAETRLSGYPRFFIQVAIRKLASLMERKYGLDGERCMLFPSYRVAEQCRLFVQASFSGVRVVSLLVCQEDNKNARIVECKEDTGLSMQPASENHLHIVLFPTDALPVAKLFWQFTGTGISSRFADHWLSTLPDDVVRTNGISGSTSVQYLTNKSPGDYSVGLELTPLPDAASAKYVLRQRIAGALNVYDRQGGPYAVQENLQVGPNSHGIADVSENDVYLFPTGMCAIWNAHRLSLAVRSAEKSVCFGFVYCDTLKVLEKWGPGCHFFPEGNDYDIDQLEVILEQESARDSTKPPILALYTEFPSNPLLRSPNLPRLRALADKYDFLMVIDDTLGNFVNVDVLPYADIVVTSLSKIFSGSANVMGGSLVLNTNGHHYTALAAYMTAHYEDTYYDEDAICMEQNSRDLQQRIKIIDTNAEALCDFLRSHSVAAGAAKSVIKEVFYPKYKTPENYERCRKTVSNHNASLSSSNEVGGYGGLFSITFISNAASRAFYESLDCFRAPSLGTNFTLAVLYTILAHHDELEWAAQCGVEEGLVRVSVGMENTETLLKVFEVALSTAKKAVATA
What is the function of this protein?
Cystathionine gamma-synthase-like enzyme; part of the gene cluster that mediates the biosynthesis of the psychoactive metabolites ibotenic acid and muscimol (PubMed:32233056).  The first committed step is glutamate hydroxylation by the 2-oxoglutarate-dependent dioxygenase iboH, and the last step is decarboxylation of ibotenic acid to muscimol by the decarboxylase iboD (PubMed:32233056).  The order of the intermediate reactions is somewhat ambiguous (Probable).  IboA likely activates the carboxylic acid at position 5 to introduce an amide bond, and the flavin monooxygenase iboF generates the N-O bond (Probable).  There are several options for the latter step (Probable).  One option is that iboF directly hydroxylates the amide nitrogen formed by iboA to produce a hydroxamic acid species (Probable).  Another option is that iboF hydroxylates an external N-containing compound, whose resulting N-O bond is subsequently introduced into the hydroxyglutamate scaffold (Probable).  The paralogous PLP-dependent cystathionine gamma-synthase-like enzymes iboG1 and iboG2 are likely involved in substitution of the OH group at position 3 by the O-N moiety (Probable).  The first cyclic intermediate is most probably tricholomic acid which is likely desaturated to ibotenic acid by the cytochrome P450 monooxygenase iboC (Probable).
What are the official names of this protein?
Cystathionine gamma-synthase-like enzyme iboG1, Ibotenic acid biosynthesis cluster protein G1.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.