PharMolix/UniProtQA huggingface dataset:
Protein: EXGB_ASPFC
Sequence: MIRRLAAFSALSGLATAWLPEVNKKITSTNGTNLFTSSNGKIRGVNLGSQFVFEPWIAEKAWSDMGCGGQKSEFDCVSRLGQANANSAFASHWGSWITQDDIAEMVSYGLNTIRVPVGYWMREDLVYSDSEHFPQGGLQYLENLCEWASDAGLYIIIDLHGAPGAQTPQNPFTGQYAPIAGFYQDYQFERALKFLEWMTTNIHQNDKFRNVGMLEVVNEPVQDAGKVGSMRSSYYPNAFKRIRAAEQSLNIDRNNYLHIQMMDRLWGSGDPNESLTDTYYAAYDDHRYLKWASVAVSKDSYISTSCSDQLNSNTPTIVGEWSLSVPDNVQWNSDWSPDSNKDFYKKWFAAQVTAYERQQGWIFWTWKAQLGDYRWSYQGGLLLTRPGIGDQQVLTL
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides (By similarity).
What are the official names of this protein?
Probable glucan endo-1,6-beta-glucosidase B, Beta-1,6-glucanase B, Endo-1,6-beta-D-glucanase B, Endo-1,6-beta-glucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS28_METM7
Sequence: MADDMVYQEAVAAEVIQINGRTGVTGEIFQVRCKILGGKDTGRILTRNVKGPVKLGDFIMLRETEREAKQLGKRRK
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: PYRI_CITK8
Sequence: MTHDNKLQVEAIKRGTVIDHIPAQVGFKLLTLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLTEEQVNQLSLYAPQATVNRIDNYDVVGKSRPSLPDRIDNVLVCPNSNCISHAEPVSSSFAVKKRTDDIALKCKYCEKEFSHYVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: TCIM_BOVIN
Sequence: MKAKPSHPAFSMSTSLRVSPSIHGYHFDTASRKKAVGNIFENIDQEALQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH
What is the function of this protein?
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type.  May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1.  Enhances the proliferation of follicular dendritic cells.  Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle.  In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity.  Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity).  Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity).  In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis.  However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).
What are the official names of this protein?
Transcriptional and immune response regulator.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Note=Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H(2)O(2).
Protein: RP147_MONPV
Sequence: MAVISKVTYSLYDQKEINATDIIISHIKNDDDIGTVKDGRLGAMDGALCKTCGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREPYSDDINLKELSVHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCFVNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLIIRPAISFWIDSIPKETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTTSINLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPTYIRNTLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIHLLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIANSQNADFDGDEEWMILEQNPKAVVEQSILMYPTTLLKHDIHGAPVYGSIQDEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIGEKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFIIKSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKYLKDVRDGKIVPLSKALEADYLESMLSNLTNLNIREIEEHMRQTLIDDPDNNLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDSKDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKIIKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTWYLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKDLYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIFEKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKLGFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPDITLRKETDRYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETFIEDEDNIRFTIYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYTGYNDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAARGYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTLKRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLGLLMRMERKLSDKISSQKIKEIEETEDF
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 147 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 147 kDa subunit family.
Protein: CHRD_MOUSE
Sequence: MPSLPAPPAPRLLLGLLLLGSRPASGTGPEPPALPIRSEKEPLPVRGAAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWARRGRGPGRVSCKNIKPQCPTLACRQPRQLPGHCCQTCPQERSNLDPQPAGLVFEYPRDPEHRSYSDRGEPGVGERTRADGHTDFVALLTGPRSQAVARARVSLLRSSLRFSVSYQRLDRPSRVRFTDPTGNILFEHPATPTQDGLVCGVWRAVPRLSVRLLRAEQLRVALVTSTHPSGEVWGPLIWQGALAAETFSAILTLEDPLQRGVGGIALLTLSDTEDSLHFLLLFRGLLGGLAQAPLKLQILHQGQLLRELQANTSAQEPGFAEVLPSLTDQEMDWLELGELQMVLEKAGGPELRISGYITTRQSCDVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVVGTGSEVVAMTLETKPQRKNQRTVLCHMAGLQPGGHMAVGMCSGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVTALCYSGHSARYDRLPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGMPGPQRLLKGFYGSEAQGVVKDLEPVLLRHLAQGTASLLITTKSSPRGELRGQVHIASQCEAGGLRLASEGVQMPLAPNGEAATSPMLPAGPGPEAPVPAKHGSPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCICQRRTVICDPVVCPPPSCPHPVQALDQCCPVCPEKQRSRDLPSLPNLEPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGATGEVHCEKVQCPRLACAQPVRANPTDCCKQCPVGSGTNAKLGDPMQADGPRGCRFAGQWFPENQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSPPLSCGSGKESRCCSHCTAQRSSETRTLPELEKEAEHS
What is the function of this protein?
Dorsalizing factor.  Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
What are the official names of this protein?
Chordin.
What is the protein family that this protein belongs to?
Belongs to the chordin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DADA_SHIF8
Sequence: MRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYENATRDIAVLEDAGVPYQLLESSRLAEVDPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPVDQLLCDGEQIYGVKFGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGSTRFKNLWLNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPSRPGHLHGAHS
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: CABYR_MACFA
Sequence: MISSKPRLVVPYGLKTLLEGISRAVLKTNPSDINQFAAAYFQELTMYRGNTTVDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPEKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAEPGAEQTEAVGDSSSKPATPKATTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIEEVPSSEAAEDVMVAAPLVCSGKVLEVQVVSQTSVHVDLGSQPKENEAEQSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVIEGVVYIEQLPEQIVTPFTDQVACLKENEQSPPVSPKSVVEKTTSGISKKSVESVELAQLEENAKYSSVYVEAEAAALLSDTSLKGQPEVPAQLLDAEGAVKIGSEKSLHLEVGITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGEATAE
What is the function of this protein?
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.  May bind calcium in vitro (By similarity).
What are the official names of this protein?
Calcium-binding tyrosine phosphorylation-regulated protein.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Protein: DED1_EMENI
Sequence: MADGLNMGSLTLNDSQHAPAPGGPPSGGRAAYIPPHLRQRQVNANGDGASAPPPGPTGGSWGGPRGPRGGNWANANAPDFNPRGPNGNTNTNSGWTATEAGRPLFNPNAYGNPGHGGGYAGASARGSGDGQWRDGKHIPGPPNPRLERELFGVPNDPTKQNTGINFANYDDIPVEASGHDVPEPVNTFTNPPLDDHLISNIALARYQTPTPVQKYSIPIVMNGRDLMACAQTGSGKTGGFLFPILSQAYQNGPAAPPPSAAGQFGRQRKAYPTSLILAPTRELVSQIFDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLVNIKYLILDEADRMLDMGFEPQIRRIVEGEDMPNVNDRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDHDKRSVLLDILHTHGTTGLTLIFVETKRMADALSEFLINQRFPATAIHGDRTQRERERALEMFRSGRYPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRDLIDLLKEAHQEVPSFLESIAREGSGYGGRGGRGGRGRGANATRDMRRMGGGMGGPPSYGGGSGFGAPASNYGGGYGGAPSYGGAGYGGGYGGGGYGNPSGSTGPSSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase ded1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_RHOPA
Sequence: MQRAARPLVSVSDLDADKAAALKLIPIPSALEARLDAYVALLQQWQAKTNLVAPSTLPQLWTRHVADSLQLVSLMPHARRWLDFGSGGGFPGVVLACAMADVGGHVTLVERIAKKAAFLREALRVAGAPGTVILADIGDNVDRFPQALDCITARAVAPLHQLIGFAEPLMTPGTTKALFLKGQDVDAELTETTKYWKFQPKLHASVTGGQGWIVEIDHIERRT
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPM1M_MOUSE
Sequence: MSAGWFRRRFLPGGPLPEPRPAGPRSSPVPYHRPRFLRGSGSSPGATDASRRPDARPVRSPARGRTLPWNAGYAEVINAEKSEFNEDQAACGKLCIRRCEFGIEEDQEWLTVCPEEFLTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGMIAPQPPMHLSGRCVCPSDPQFVEEKGIQAEDLVIGALENAFQECDDVIGRELEASGQVGGCTALVAVFLQGKLYVANAGDSRAILVRRHEIRQLSSEFTPETERQRIQQLAFTYPELLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMRGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRVLDTDIQLKPFLLSIPQVTVLDVHQLAVQEEDVVVMATDGLWDVLSNEQVALLVRSFLTGNQKDDPHRFSELAKMLIHNTQGKDNGATGEGQVSYDDVSVFVIPLHSQAQEGSGH
What are the official names of this protein?
Protein phosphatase 1M, Protein phosphatase 2C isoform eta, PP2C-eta, PP2CE.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENL04_ARATH
Sequence: MVFVKMTDVYLMIVMLMGLGFSIELSNGHKFYVGGRDGWVLTPSEDYSHWSHRNRFQVNDTLYFKYVKGKDSVLEVSEKEYNTCNTTHPLTSLSDGDSLFLLSRSDPFFFVSGNSGSCLKGQKLAVTVMSTGHHSHTPRHPSPSPSPSASPVRKALLSPAPIPVHKALSSPAPTPGVDPSHSEVLAPAPGPAAAVRNLAGSVAPGVISLGLVLVIMISSMV
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-like protein 4, AtENODL4, Phytocyanin-like protein ENODL4.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: ACEK_YERP3
Sequence: MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCLTSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC25_ARATH
Sequence: MGRSIFSFFTKKKKMAMARSISYITSTQLLPLHRRPNIAIIDVRDEERNYDGHIAGSLHYASGSFDDKISHLVQNVKDKDTLVFHCALSQVRGPTCARRLVNYLDEKKEDTGIKNIMILERGFNGWEASGKPVCRCAEVPCKGDCA
What is the function of this protein?
Arsenate reductase that plays a major role in the reduction of arsenate to arsenite and arsenic retention in roots (PubMed:16567632).  Has an in vitro and in vivo arsenate reductase activity (PubMed:16507083, PubMed:16766666, PubMed:22562211).  Plays no role in arsenic metabolism (PubMed:22879969, PubMed:25464340).
What are the official names of this protein?
Dual specificity phosphatase Cdc25, Arath;CDC25, Arsenate reductase, AtASR, Arsenate reductase 2, Sulfurtransferase 5, AtStr5.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAK_METFK
Sequence: MGKIIGIDLGTTNSCVAVMEGGKPRVIENAEGARTTPSVIAYQEDGEILVGAPAKRQAVTNPKNTLFAVKRLIGRRFDEKEVQKDIGLMPYTITKADNGDAWVEVRGQKLAPPQISAEVLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKQEGDRKIAVYDLGGGTFDISIIEISEIDGEHQFEVLSTNGDTFLGGEDFDNRLIDFLADEFKKENGIDLRNDLLAKQRLKEAAEKAKIELSSSTQTEVNLPYITADASGPKHLVVKITRAKFESLVEDLIERSIKPCEVALKDAGVKVSDIQDVILVGGQTRMPKVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLQGDVKDVLLLDVTPLSLGIETLGGVMTKLIQKNTTIPTKASQVFSTAEDNQSAVTIHVLQGEREMASGNKSLGQFNLTDIPPAPRGMPQIEVTFDIDANGILHVSAKDKATGKENKITIKANSGLSDEEIKRMEEEAAKYADEDKKLRELVDARNSADSAIHSVKKSLAEHGDKLDAAEKGAIEKAVQELEDVIKGDDKAAIESKTNALIEASQKLGEKVYAAGETESSAAEPGEPQEKTVDAEVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: DUS22_MOUSE
Sequence: MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLRDAEEAKNILAAPGILKYWAFLRRL
What is the function of this protein?
Activates the Jnk signaling pathway.
What are the official names of this protein?
Dual specificity protein phosphatase 22, Low molecular weight dual specificity phosphatase 2, LMW-DSP2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_STAEQ
Sequence: MFKFNEDEENLKCSFCGKDQDQVKKLVAGSGVYICNECIELCSEIVEEELAQNTSEGFTELPTPKEIMDHLNEYVIGQEKAKKSLAVAVYNHYKRIQQLGPNEDDVELQKSNIALIGPTGSGKTLLAQTLAKTLNVPFAIADATSLTEAGYVGDDVENILLRLIQAADFDIDKAEKGIIYVDEIDKIARKSENTSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPNQELIQIDTTNILFILGGAFDGIDEVIKRRLGEKVIGFASNEADKYDEEALLEQIRPEDLQSYGLIPEFIGRVPIVANLETLDVAALKNILTQPKNALVKQYTKMLELDNVELEFSEEALSAISEKAIERKTGARGLRSIIEEALIDIMYDVPSSENVSKVVITEQTINEEIEPELYDDEGNLINKNKTSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SECB1_POLNA
Sequence: MAEANLDPVFQIQRVYLKDLSLEQPNSPEILLNQEQPGVEIQLGVDAKPVAEGLFEITVTATVHTKIEEKTVFMVEAKQAGIFEIRNIQSDQMGALLGIACPQIVYPYLRSNVADIIQRGGFPPVHMAEINFQAMYEQQQAEAMMATSEAPQILV
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB 1.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRBG_ECOLI
Sequence: MLLATALLIVGLLLVVYSADRLVFAASILCRTFGIPPLIIGMTVVSIGTSLPEVIVSLAASLHEQRDLAVGTALGSNIINILLILGLAALVRPFTVHSDVLRRELPLMLLVSVVAGSVLYDGQLSRSDGIFLLFLAVLWLLFIVKLARQAERQGTDSLTREQLAELPRDGGLPVAFLWLGIALIIMPVATRMVVDNATVLANYFAISELTMGLTAIAIGTSLPELATAIAGVRKGENDIAVGNIIGANIFNIVIVLGLPALITPGEIDPLAYSRDYSVMLLVSIIFALLCWRRSPQPGRGVGVLLTGGFIVWLAMLYWLSPILVE
What are the official names of this protein?
Inner membrane protein YrbG.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPC_ROSCS
Sequence: MDTMLNRILAHKRIEVERQRIKTPYDQMRTRAETAPPPRDFGAALRAHHPIALIAEVKKASPSKGVLIENFDPLALARTYASNGAAAISVLTDVRFFQGHLKYIEGIRALFDRGAAPPLPLLRKDFMIDPYQIVEARAYGADAVLLIVAALDDETLAALLALAGDLGMQALVEVHNADELRRALAVGARIIGVNNRDLHSFTTTLETTRHLAALLPSENRPLLVSESGIFTADHVALVRSWGVDAVLVGEALVTAPDIAGKVRELGGRL
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: GLNE_SHIDS
Sequence: MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKLVLTFSDFVQDSVIAHPEWLMELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLFSENDAKQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGVLTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDVRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMALPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMVLTRAYTTLRDELHHLALQELPGHVSEDCFTAERDLVRASWQKWLVEE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: RL18_MESHJ
Sequence: MQKSRNYYRKAKHVRILKKLKSNREDKQKYRIGIYKSLRNFYAYIFDPWKNKVITSVSTLDKSNGYKGNIVSASSLAPDLYKKMKKLNLENESYIFDRGGYLFHGRVKAFANALRDQGVKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GLMU_STUS1
Sequence: MSLDIVILAAGQGTRMRSALPKVLHPVAGQSMLGHVIATARALQPRSIQVVIGHGAEQVRQRLAGDDLNFVVQAEQLGTGHAVAQALPHLSAERVLILYGDVPLIEAETLQRLLQKVGPEQLALLTVTLDDPTGYGRIVRDGRGEVQAIVEHKDASADQRAIREGNTGILAVPGSRIGEWLGRLSNSNAQGEYYLTDVIAMAVADGLRVATEQPADAMEVQGANDRIQLAELERHYQLRAARRLMAQGVTLRDPARFDLRGEVSVGRDVLIDVNVVLEGRVVIEDDVQIGPNCVIKDSTLRRGAVVKANSHLEGAVMGEGADCGPFARLRPGSLLGAKAHVGNFVEMKNASLGDGAKAGHLSYLGDAEIGARSNIGAGTITCNYDGANKFRTVMGEDVFIGSNSSLVAPLNLGDGATTGAGSTITDDVPAHTLALGRGRQRNIDGWQRPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
Protein: RL23_DEIGD
Sequence: MSQYDIIKQPVISEKAYAGMERGVYSFWVDPKATKPEIKAAIQNVFGVTVVGISTMNVPGKRKRVGKFVGYRADRKKAIVRLAEGQTITALEGQA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PURA_ECO7I
Sequence: MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.