Protein: SQSTM_MOUSE
Sequence: MASFTVKAYLLGKEEATREIRRFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVLFPTLRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRREHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPPEDPNVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPTTPESSSTGTEDKSNTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPEEQMESGNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
What is the function of this protein?
Autophagy receptor required for selective macroautophagy (aggrephagy) (By similarity).  Functions as a bridge between polyubiquitinated cargo and autophagosomes (By similarity).  Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (By similarity).  Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity).  Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity).  Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity).  May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (By similarity).  May play a role in titin/TTN downstream signaling in muscle cells (By similarity).  May regulate signaling cascades through ubiquitination (By similarity).  Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763).  May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels (By similarity).  Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity).  Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity).  Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20421418, PubMed:20173742, PubMed:24011591).  Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity).
What are the official names of this protein?
Sequestosome-1, STONE14, Ubiquitin-binding protein p62.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus, PML body. Cytoplasm, myofibril, sarcomere. Note=In cardiac muscles, localizes to the sarcomeric band (By similarity). May also localize to the hepatocellular carcinoma (By similarity). Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (PubMed:20421418). Co- localizes with TRIM5 in the cytoplasmic bodies (By similarity). When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies (By similarity).