PharMolix/UniProtQA huggingface dataset:
Protein: NCAM1_HUMAN
Sequence: MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQTKENESKA
What is the function of this protein?
(Microbial infection) Acts as a receptor for Zika virus.
What are the official names of this protein?
Neural cell adhesion molecule 1, N-CAM-1, NCAM-1.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor, GPI- anchor. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Lipid- anchor, GPI-anchor. SUBCELLULAR LOCATION: [Isoform 5]: Secreted. SUBCELLULAR LOCATION: [Isoform 6]: Secreted.
Protein: RECA_CHLCH
Sequence: MTMDNPKVEQAGHAVDSAKLKQLNLAVDALEKQFGKGTIMRMGDGSAGLTVQAISTGSMALDFALGVGGLPRGRVTEIYGPESSGKTTLALHVIAEAQKEGGITAIVDAEHAFDPSYARKLGVDINALLISQPESGEQALSIVETLVRSGAVDVVVVDSVAALVPQAELEGEMGDSSMGLQARLMSQALRKLTGAISKSSTVCIFINQLRDKIGVMYGSPETTTGGKALKFYSSVRLDIRKIAQLKDGDELTGSRTRVKVVKNKVAPPFKMAEFDILYGEGISALGELIDLGVEFGVIKKAGSWFSYGTEKLGQGRESVKKILREDPVLYQKIHMQVKELMTGHTEIISSPTE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATA_BORBZ
Sequence: MNTKGKVVGVNGNLVTIEVEGSVFMNEVLFVKTAGRNLKAEVIRIRGNEVDAQVFELTKGISVGDLVEFTDKLLTVELGPGLLTQVYDGLQNPLPELAIQCGFFLERGVYLRPLNKDKKWNFKKTSKVGDIVIAGDFLGFVIEGTVHHQIMIPFYKRDSYKIVEIVSDGDYSIDEQIAVIEDDSGMRHNITMSFHWPVKVPITNYKERLIPSEPMLTQTRIIDTFFPVAKGGTFCIPGPFGAGKTVLQQVTSRNADVDVVIIAACGERAGEVVETLKEFPELMDPKTGKSLMDRTCIICNTSSMPVAAREASVYTAITIGEYYRQMGLDILLLADSTSRWAQAMREMSGRLEEIPGEEAFPAYLESVIASFYERAGIVVLNNGDIGSVTVGGSVSPAGGNFEEPVTQATLKVVGAFHGLTRERSDARKFPAISPLESWSKYKGVIDQKKTEYARSFLVKGNEINQMMKVVGEEGISNDDFLIYLKSELLDSCYLQQNSFDSIDAAVSSERQNYMFDIVYNILKTNFEFSDKLQARDFINELRQNLLDMNLSSFKDHKFNKLEHALGELINFKKVI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: Y358_MYCPN
Sequence: METQNQIETLRYIFNQLNNQDKPQIIWFSGEGEDEKINFLIRLDNYFQPTFVQDLTINFLPAFVKRNKKNPPNTLAKGNFVNIANKLLAVLARSLSWKQLNKPQQKWLLWLLVPFLLLRQLWLKKKVSKIFQFVNERGILSFIKEQWPILTTLVTVGTTLGTPIFSITISQQKAILENAGHGAFVFLVIFSVFAIALGLVSSLIFLVSSLFSIRQKKSLQQLHQILSRLINKYFCFANSEQNQTGRYQLKNTGVCFFYGFDFEEKEYITQAMNLLLLLKQTNCFVLVGCKESNMLLIKNKVEPDINLKQSSLYLDLKSQISPLAQISKYNLLFEELALDADMFYLEDFFALLKTPRQIVNFLFRIKQNLKEFHQPQTLWFDYLALWALVIATDFEFNNVLWSFNDYLSLTNKQKEDYASVNLTAFFNRSLKNHKDNSLLFKPELFNTHAYIPETYTQVTLENIDSDKRAQLVPLNWFSQQKFSDFIEEKINFWQTQQAENKVFYLTLGERIFFLVLVNKKFKQIKLEAALKYLN
What are the official names of this protein?
Uncharacterized protein MG255 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DDX6_DICDI
Sequence: MNSQQNKLPQQPQQPPSSIVDDDNWKSQLKLPPRDERRQTEDVTATEGNDFDDLHLKRDLLRGIFEKGYVKPSPIQEKAIPIALAGRDIMARAKNGTGKTASFLIPALEKTDPTKDVIQVLILVPTRELALQTSQVCKELGKYMNVQVMASTGGTSLKDDIMRLYNPVHILVATPGRVLDLAQKNVANLSNCHTMIMDEADKLLSQEFQPLVEQLINFLPQQRQILLFSATFPVTVKSFKEHYLQQAFEINLMEELTLKGVTQYYAFVEERQKIHCLNTLFSKLQINQSIIFCNSVNRVELLAKKITELGYSCFFIHAKMVQAHRNRVFHDFRNGACRNLVSSDLFTRGIDIQDVNVVINFDFPKHSETYLHRIGRSGRFGHLGLAINLITYEDRFSLYKIEQELGTEIKPIPPVIDKSLYAA
What is the function of this protein?
ATP-dependent RNA helicase which may be involved in mRNA turnover.
What are the official names of this protein?
Probable ATP-dependent RNA helicase ddx6, DEAD box protein 6.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules.
Protein: AROC_SULIM
Sequence: MPGNSFGKLFRVTTFGESHGPAVGVVIDGVPAGLPLTVEDIKFELEFRRPGRLYVSGRREKDEPEILSGIFNNRTTGSPIAVIVRNTDVISSFYEEIRYKPRPGHADLPFIMKYGYENWDYRGGGRASARETVGRVIAGAVAKKLLMLADTWIAGHLRSLGPEELNEEVTFEEVLCSKYSPVRASKKVLEEKYEALIKKATQEGDSYGGIAEVITKNPPIGLGEPVFDKMKAELAKAIMSIPAVTGFEYGLGFMVSKMKGSEANDEIIRKDNKIGWKYNYAGGILGGLTNGEDLIVRCAFKPTSSIRKPQKTIDLRNLEETYISVIGRHDPAVAIRGVTVVESMVALTLVDHAMRAGVIPLVKLTEEQGNIVQQRWERYVRSCKPMEESQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: HEY1_HUMAN
Sequence: MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
What is the function of this protein?
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750).  Downstream effector of Notch signaling required for cardiovascular development.  Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development.  May be required in conjunction with HEY2 to specify arterial cell fate or identity.  Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification.  Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867).  Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif protein 1, Cardiovascular helix-loop-helix factor 2, CHF-2, Class B basic helix-loop-helix protein 31, bHLHb31, HES-related repressor protein 1, Hairy and enhancer of split-related protein 1, HESR-1, Hairy-related transcription factor 1, HRT-1, hHRT1.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRDR_POLNS
Sequence: MRCPFCHNEDTQVLDTRVSDEGDTIRRRRRCAKCDKRFTTYERVELALPAIVKKNGSRVEYSHDKLASSIKLALRKRSVSSDSVDESIARIEEKLLSFGEKEIPSERVGELVMRELKRLDKVAYIRFASVYRSFADIESFESALKELK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: COL34_CAEEL
Sequence: MDLETRIKAYRFVAYSAVAFSVVAVISVCVTLPMVYNYVHHVKRTMHNEITFCKGSAKDIWNEVHALKSLPNSNRTARQAYNDAAVTGGGAQSGSCESCCLPGPPGPAGTPGKPGRPGKPGAPGLPGNPGRPPQQPCEPITPPPCKPCPQGPPGPPGPPGPPGDSGEPGSPGLPGQDAAPGEPGPKGPPGPPGAPGAPGTPGEPGVPAQSEPLIPGEPGPPGEAGPQGPPGSPGQPGADGSPGQPGPKGPNGPDGQPGADGNPGAPGPAGPPGSPGERGICPKYCAIDGGVFFEDGTRR
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
What are the official names of this protein?
Cuticle collagen 34, Abnormal ray morphology protein 4.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: LATA_LATGE
Sequence: NEELTLEEKAEICSELELQQKYADIASNIIGDLSSLPMVGKIVGTIAAAAMTVAHVGSGRLDIEQTLLGCSDLPFDQIKEILETRFNEVDRKLESHSAALEEITKLVDKSISAVEKTRKQMNKRFDEVMKSIQDAKVSPIVSKINNFAKYFDAEKERVRGLKLNDYILKLEEPNGILLHFKDVRTPKDDSLQSPLFSIIQERYAIPKTVDDELAFKVLYAILYGTQTYVSVMFFLLEQYSFLANHYYEKGDLEKYDEYFNNLNNVFLDFKSSLVGSGASNNEGLIDNVLQVLMTVKSNEFLGLGKNSLEEMLNEKINLFSKIKEEIEGKQRMTLSETPENFARISFEKDITTPIGDWRDSREVRYAVQYASETLFSKIGHWSDPVSVRAKACPTLRMPVDQTRRNVLVFRKFDNSKPQLVGEITPYQSNFIDIDRDLYNAASNPDSAVGFMEFKKLISNGANIRAVFNQGRTVFHAAAKSGNDKIMIELTFFSKYTDINQPDKKGYTPIHVAADSGNAGIVNLLIRSGISVNSKTYNFLQTPLHLAAQRGFVATFQRLMESPEININERDKDGFTPLHYAVRGGERILEAFINQAGIDVNVKSDKGLTPFHLAVIKNDWPVASTLLRSKKIDINAIDENNMTALHYAAILGFLETTKQLINLKEINANAVSSPGLLSALHYAILYKHDDVALFLLKSSKVNYNLKAFGDITPLHLAVMQGRKQVLSEMFNIGININQKTAEKYTPLHLAAMSKYPELVEILLDQGSNLEAKTITGATPLNLATFKGKSQAALILLKDEVNWREPDENGQMPIHGAAMNGLLDVAQAILYLDATVLDIEDKNLDTPLNLAAQNSHIDMVKYFIDLGAKVNTRNKKGQAPLLAFSKKGNLDMVKYLFDKNANVYIADNDGLNFFYYAVRNGHLNIVKYAMSEKDKFEWSTTDNNRSDGCSGECAISHFAVCDAVQYDKIEIVKYFVGTLGHYSICSPLHQAARYGHIHIVKYLVEEEVLSVDGSKPDTPLCYASENGHLAVVQYLIRNGAKVNHDCANGMTAIDKAITKNQLQVVQILAENGVDFRRKNRLDATPFLTAVASNSYEIAEYLIREKRQNININEQNGNKETALHLAVYYKNLQMIKLLVKYGIDENIRNGYDKTALDIARDNKISSIVEYLQTKSGKFRREYKSSNGEHDLLHENRISNFTDSKNLEYQHQHFINADNDASQSFSNTAANQNIDVIGTLLLIDVLIRRFSKQGYINNKPDSASDGIAQAAALAITEKFEDILNSLHNKSTEEQVDFAEVHRKIYAALRSGRNSQVHQVLCSSLKSISTLKPEDIKKLVSVVLSFQSSISLPEVSASAREVYGETLHLFHES
What is the function of this protein?
Presynaptic neurotoxin that causes massive release of neurotransmitters from vertebrate (but not invertebrate) nerve terminals and endocrine cells via a complex mechanism involving activation of receptor(s) and toxin insertion into the plasma membrane with subsequent pore formation.  Binds to neurexin-1-alpha (NRXN1) in a calcium dependent manner, adhesion G protein-coupled receptor L1 (ADGRL1, also termed latrophilin-1 and calcium-independent receptor of latrotoxin (CIRL)), and receptor-type tyrosine-protein phosphatase S (PTPRS), also termed PTP sigma.  NRXN1 and PTPRS are suggested to provide a platform for binding and subsequent pore formation events.  In contrast, binding to ADGRL1 does not involve oligomerization and channel formation, but direct downstream stimulation of the synaptic fusion machinery.
What are the official names of this protein?
Alpha-latrotoxin-Lg1a, Alpha-LTX-Lg1a, Alpha-latrotoxin, Alpha-LTX.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a membrane channel in the prey.
Protein: GMHA_HISS2
Sequence: MYLEQVKTELFEAQDVLNKFISNEQNIKLIQQAALLISDSFKQHGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYEHVFSRYVEAVGQKGDVLLGISTSGNSKNVLNAIEAAKAKGMKVIALTGKDGGKMAGLADVEIRVPHFRFADRIQEIHIKVIHILIMLIEFEMAKIRQ
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_SALDC
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPAEPAQELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGALLPRYVFIHGGPRVFTYYTPKEESVKLFHDYLDLHRSNPALDVQMVPVSVMFGRAPGREKGEDNPPLRMLNGVQKFFAISWLGRDSFVRFSPSVSLRRMADEHGTDKIIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASKAIARAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLKGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPEWRESIDPIEAIRPAWLTPTVNSIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLDCYLDLMRNVPYSTDSTVPAASAGELIAHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLIMPSLMAAIITQHRRISRDALQQHVEALYPMLKAELFLRWEREELASVIDALASEMQRQGLITLQDDELHINPTHSRTLQLLAAGARETLQRYAITFWLLSANPSINRSTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDTGDAEPAETMKIYQMLADLITSDVRLTIESATQGE
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METE_COXB2
Sequence: MVYAHNLGFPRIGIKREMKKTVEAYWRGEISQQQLQQQAIELQLTNWKIQAEAGVDLIPVGDFSWYDHVLDMAVRVGAIPSRFKALNSNITDTMFCTARGQAPNGIETSACEMTKWFDTNYHYIVPEFTTNQSFELHHDDLFKSTKLALENNYRAKPVILGPLSFLWLGKCKGESFNKLLLLEKLLPVYAEIFEQLSSLGVEWVQVDEPILVLDLPPEWQQAFLTTYQQLNFFNLKCLLATYFGSLDDNLSLTCQLPVDGLHIDYCRAPDQLDSVLSQLPAEKILSVGIVDGRNIWCNDLNRSLTLLENIQSSLGDRLWVAPSCSLLHVPIDLDQENKLDVELKSWFAFAKQKVAEAAFLTRGLREGRESIGAELKKNEEVIISRKTSKRIHNPNVEKKAASVNERLMRRQHEHSIRKNKQTAQLNLPLFPTTTIGSFPQTSKIRCLRRDYKQGKIDDALYEEKIRQEIAEVIGIQVKLGLDVLVHGEPERNDMVEYFGELLDGIAITSNGWVQSYGSRCVKPPIIFGDVSRERPMTLRWIEYAQSLTTKSVKGMLTGPVTILAWSFVRDDQPRSQTAKQIALALRDEVQDLERSGVRVIQIDEPAFRECLPLRKAAWQDYLEWAVKCFRLASCGVKDETQIHTHMCYSEFNDIIEAIAALDADVITIESSRSEMEILKSFEKFAYPNDIGPGIYDIHSPRIPRVAEIEELAVRALQYIPIERLWINPDCGLKTRNWEETKEALSRMVDAAKHLRKAFSSEKTPTIDLELQPAST
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: S10A1_MOUSE
Sequence: MGSELESAMETLINVFHAHSGQEGDKYKLSKKELKDLLQTELSGFLDVQKDADAVDKVMKELDENGDGEVDFKEYVVLVAALTVACNNFFWETS
What is the function of this protein?
Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:11909974, PubMed:16952982).  In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes.  These changes allow interactions with specific target proteins and modulate their activity.  Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:17438143).  Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity).
What are the official names of this protein?
Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Cytoplasm. Sarcoplasmic reticulum. Mitochondrion.
Protein: AGO4_XENLA
Sequence: MGRKTLCESETVCRDVTINGSAGCLQNVGPPPTNLFQPPRRPGLGTLGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMPIFGDNQPGYDGKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVTIQWVSVVSLQLLLEALSGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPVIEFMCEVLDVQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETTQELLYSQEVIQDLCNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELMAIRKACISLEEDYRPGITYIVVQKRHHTRLFCSDKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHSMYFA
What is the function of this protein?
Required for RNA-mediated gene silencing (RNAi).  Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them.  Lacks endonuclease activity and does not appear to cleave target mRNAs.
What are the official names of this protein?
Protein argonaute-4, Argonaute4, Argonaute RISC catalytic component 4, Eukaryotic translation initiation factor 2C 4, eIF-2C 4, eIF2C 4.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: PYRG_PSET1
Sequence: MSTKFIFVTGGVVSSLGKGIAAASLAAILEARGLNVTILKLDPYINVDPGTMSPIQHGEVYVTEDGAETDLDLGHYERFIRTKMTSRNNFTQGRVYKDVLHRERRGEYLGATIQVIPHITNDIKQRVYSGAEGYDIALVEIGGTVGDIESQPFLEAIRQMGTEIGRERALFIHLTLVPFLGPAGEVKTKPTQHSVKELRSIGIQPDILICRSDRKLPSNERAKIALFTNVEEKAVISLPDVDSIYKIPALLKSQDLDYFVCRRFHLDVPEADLVEWEQVLYQESNPTGEVTIGMVGKYIELPDAYKSVNEALKHAGLKNRLTVNIQYIDSQDLETKGVDSLAHLDAILVPGGFGGRGVEGKILAAKYARENKVPYLGICLGMQVALIEYARNVAGLVDANSTEFNAQSASPVVGLITEWLDAEGKVEQRDEKSDLGGTMRLGAQKCHLTPGSKVHAVYGSDEIVERHRHRYEVNNNFVEQLEKAGLSFTGLSEDKKLVEIIENKDHPWFIAAQFHPEFTSTPRDGHPLFEGFVAAAHIHQKASS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y1524_ARCFU
Sequence: MREDRLFARFVEYSFFAVFAALIVSYALDKLFGTSLSPLLVFLLTLIPAIGLILILPFSSRKTAILTVAVLIEMAVALYLAFR
What are the official names of this protein?
Uncharacterized protein AF_1524.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIAA_RALPJ
Sequence: MIASAASAPRAICLLGPTASGKTAAALKLAERWPVEIISMDSALVYRGMDIGTAKPSAEEQAIAPHHLIDIIDPLDAYSAAQFANDANALIDAIRARGKLPLIVGGTMLYYKALTQGLSDLPGADPAIRAEIDAEAARDGWPALHAKLALVDPVTAARLHTTDAQRIQRALELYRLTGQPMSALLAREVGANAFQQHDAAAPYLTIALEPSDRLVLHARIAQRFDAMLAGGLLDEVEGLRRRGDLSPTLPSIRCVGYRQAWAYLEGEIDMAALREQGIAATRQLCKRQITWLRSTPERHVVDCLAPDYVDQVARLVQTSLESQSQ
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: Y5851_ARATH
Sequence: MATPTNKEHFSGGLAKVLAEKWQVDVMLKAKNSDEGSAISAHKLILASRSEVFKNMFELDEFKTSTKHVETITLSEMKHEELEAFVEFICSDGSMLSANVKQHARSLYLAADKYEILHLRDLCRTELISSLSLLNSLDLLVLAQIPFDKVLNDESFSYIKNNISTIASSDEFKLFVAGNPNLAVEIMKVSLITLTLRCSSCGSNHSLQGMYCCNCCRYGTLRLI
What is the function of this protein?
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB/POZ domain-containing protein At5g48510.
Protein: TNFL4_RAT
Sequence: MEGEGVQPPDENLENGSRPRFKWKKVLRLVVSGIKAAGLLLCVVYVCLQFSSSPAKDSPIQRLRAPVTGCEGGRLFIGTSKNEYETMEVQNNSVIINCDGLYLIHLKGSFFQEVKINLHFRKDRSPIFVPMLNNGQRVVFTVVTSLAFKDEVYLTVNASDTLCEHLQINDGELIIVQLTPNGYCAPERPYSSTVNQVPL
What is the function of this protein?
Cytokine that binds to TNFRSF4.  Co-stimulates T-cell proliferation and cytokine production (By similarity).
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: FKBP4_MOUSE
Sequence: MTAEEMKAAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYHKDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA
What is the function of this protein?
Immunophilin protein with PPIase and co-chaperone activities.  Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).  May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments.  The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.  Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.  May have a protective role against oxidative stress in mitochondria.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons.
Protein: DENR_CAEEL
Sequence: MSDGETAVIQSLAPGPIDGVSYPLKMVYCGQCSMPPEYCDYSGQTDVCRAWATQNAPELLEGLEISDEPAADGDEKKKQKRGGKGSKTGAAAAQAAASGGKKKGGGPQKVTLQREPRGKKSVTVIKGLATFDIDLKVASKLFAQKFACGSSVTGADEIVIQGDVKDDLLDLIPEKWKQVTDEQIDDLGDKKR
What are the official names of this protein?
Density-regulated protein homolog.
What is the protein family that this protein belongs to?
Belongs to the DENR family.
Protein: GLPK5_DANRE
Sequence: MGTTSIRCHVYDKSASIRGSCSAKVSLLYPQPGWVEIDPDELWDGFVTVVKGAVQDSGLQMCQMESLGISTQRATFMTWDRNTGKPFHKFITWQDMRAAELVRSWNGSCAMKTVHGVMKMLHFLSRQKRFLAASLVVFTTQHVSLRLVWALNNIPQLRQAVEDGSCYFGTIDTWLLYKLTKGLVHATDYSNASATAIFDSYQMCWSGFLCSLLSIPLSILPKVQDTSHKFGLCDSSIFGVPIPIMCVMADQQTAMFGECCFDTGDVKITMGTGTFMDINTGSKPHTSVAGLYPLVGWKIGADVVYLAEGNAAGTGAAIKWAQDLELFSDVKETEAIATSVEDSDGVFFVPSFSGLQAPLNDPKACASFMGLKPSTTKRHLVRAILESIAFRNKQLFDVMLRETRIPITKIRADGGVCTNDFIMQLTADLLGRKIARPSHFDMSCLGAAFVAGLGTGYWRNQEELKKLLSTDQHFLPRRSKSEGEKGGLYRGVLQSWEKALQRSMHWYNQP
What are the official names of this protein?
Putative glycerol kinase 5, GK 5, Glycerokinase 5, ATP:glycerol 3-phosphotransferase 5.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.