PharMolix/UniProtQA huggingface dataset:
Protein: VL2_HPV35
Sequence: MRHKRSTKRVKRASATQLYRTCKAAGTCPPDVIPKVEGNTVADQILKYGSMAVFFGGLGIGSGSGTGGRSGYVPLGTTPPTAATNIPIRPPVTVESIPLDTIGPLDSSIVSLVEETSFIESGAPVVTPRVPPTTGFTITTSTDTTPAILDVTSISTHDNPTFTDPSVLHPPTPAETSGHFVLSSSSISTHNYEEIPMDTFIVSTDSNNITNSTPIPGSRPTTRLGLYSKGTQQVKVVDPAFMTSPAKLITYDNPAYEGLNPDTTLQFEHEDISLAPDPDFMDIIALHRPALTSRKGTIRYSRVGNKRTMHTRSGKAIGARVHYYQDLSSITEDIELQPLQHVPSSLPHTTVSTSLNDGMFDIYAPIDTEEDIIFSASSNNTLYTTSNTAYVPSNTTIPLSSGYDIPITAGPDIVFNSNTITNTVLPVPTGPIYSIIADGGDFYLHPSYYLLKRRRKRIPYFFADVSVAV
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: CYAY_YERPN
Sequence: MNDSEFHQLADQLMLYIEETLDSFTGDSDIDYETNGGVMTLTFENGSKIVINRQEPLHQVWLATKAGGYHFNYRDGHWYCSRSGEEFLAKLSEAASAQAGENVSFG
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: NRDR_STRPB
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RUVA_TREPS
Sequence: MFESISGILTLHERERLCVEVHGIEWEIAVSAYSSAAFGEVGSHVKVFTWLYHREDALRLFGFSNVQERTLFLSLTKVEGIGPKQALKVLSSISSQALCAALDTGDLCALQRIPGIGKKTAQRMLLALKGTLALTDAASCAQSQTDDRAAHPSNLGCAPHAREIEDLVTALVQMGYDRKMAAEVIAQESAALCSVGRSLYEEEATVLKRAILALSIAHPHAVAPAAE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: YEC5_YEAST
Sequence: MARQDETDCKKLDSNSAFLPLCITSYRSKDEAEKLVSCLHHEGSYFLCFSYGLYTGTSNELKAKVEFALDGPFVVNYATVPMFMSASFCHLLMFNDGSIKGFKCENNKFEIIYDSNVAPKLDTISLLTSSWLNASFEGVLYTCNKNISYDSDLHTLCTTIYSFDFREGIVERFYATDGEEIISFDFISREDLLDDATCTGKSHVYFLCLLKSCYSENLFLKEYNLAGKHGSRKFDLNEYRQYNLLPICDNEFCYMKVVCGHTIVVLTTNYTQIINIKASGLTNGAFFNNKGLPNVENYQFLKDSYDVIYERSVILLTISDVYANKYTAKIHTRSLHRDHVLKELQWTKERVFKPPKHDLCDVILQLPREKYIAVTRINGVNFISKDHRGSKLEKVKSGPAYTNKVYLASQVIGNKGTDIDSLLLGGSFNSRRGFLEKKILVYDKTLFKLVTSSKALVENVTDFWVTDLALNGGDEFAYESGGLIYKNGIFLMDEPYDYGLFVSRTGKVLKAGMDGSTGEFRQVDFLQSNHNSSTMFCYPVQNSKLRISILEAKSGFLRKKEEFFIHGLNSKESIVSCFSDGAEKYLFVIYLDGVFSVWNANQKKVATSHPDYSFIAYDQLIKISWLSKKHKHDSIYVIASSYTGCVRVYKSESNFLRVDLEIHSLYDQKLELLDTIPSLPLVFLYNDKEIILLNLQNMSYGCIQLGLVPRRMRIRPGKALFSLCVLDYDSRISIFEFGSTFYREGFTKQMTSLKPQLENHIFYLPSIPVELYTVPNNLNQAVVCLVDSNSRQYKLMLFNYASMKAVSTFSFSDEKYLHAVVKPLWPEQNSIYLSQRPFYGNKFVVCLGVGEKRTKFWLFEIRNNNITQLYANYLEDCIFSVFIYYECNLVLFSGDSGIAAYKINMLKEGAEILEAYSFPALSSINHIGLPAYMSGDYLVQFEILRDFLRTRFPIRTSIVYPSEYPECPYLGFKRLGSITQVATKIIPKKLREPKNDCLASDKNYLLGRLSDLSCATLKYSNRSYVATIGIDNTLTIYEDSKLSVDKGGLAMPYLKIRLPNKIISLAAIPDGFQNLQICPNFNSQRLEGVIPLFLLCGTEGQIYIISEFIGELWMRTLHDYKKIKLECKRAFRRSEKSMRNVTKQYSVSKETGINESGFDELARNSKRRHIDHSPYKTIDFFDPVKLKR
What are the official names of this protein?
Uncharacterized protein YEL025C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DSBB_AROAE
Sequence: MQSFAFSTRALFLGLFAVCAGLLGFGLYLQHAVGLEPCPMCIMQRYAFVAIALTALVAGLHGPGRRGTRAYAAVILLLALAGGGVALRQTWMQLYPPEFAECGPDLEFMLGSFPLADALPMIFQGAGDCSKVDWAFLGLSIANWSLVCLTLVAVFAIMMIARKRGG
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPC_CROS5
Sequence: MQIRRRPPNPAVEVDILRYQVPDPNGKANHILEEIVWHKEKEVERMRDRLSLLDLRKQEQSAPPAKDFLGAISQGKTQPALIAEVKKASPSKGVIREDFEPVAIAQAYVQGGASCLSVLTDSKFFQGSFDNLALVRQAVDIPLLCKEFIIYPYQIYLARVKGADAILLIAAILKDSDLQYLIKIIHGLGMTPLVEVHSLAELDRVLAIEGVSLVGINNRNLETFEVSLETTTNLITARQDEIKERGIYIVSESGIHTPQHLQQVTEAGANAVLIGESLVKQDDPTQAIANLFSF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: ATPF_ARAHI
Sequence: MKNLTDSFVYLGHWPSAGSFGFNTDILATNPINLSVVFGVLIFFGKGVLNDLLDNRKQRILNTIRNSEELREGAIQQLENARIRLRKVETEADQFRVNGYSEIEREKLNLINSTYRTLKQLENYKNETILFEQQRTINQVRERVFQQALQGAIGTLNSCLSNELHLRTINANIGMFGTMKEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NAGB_BIFLS
Sequence: MPEIIIVKNEAEAGEIYGRCVADLIKAKPDAVLGLATGSSPLAAYQALAKIVKDEAIDVSGVRGFALDEYIGLPLTHPESYHATIHRTVVEPLGLDPAKVHVPGDVLNGTPLEDGDKVALAGPAYDRAIEAAGGIDVQILGIGTDGHVGFNEPGSSLASGTRVKTLAEQTRVDNARFFDNDINQVPTHCITQGIGTIMKARHLVLLAFGAGKAEAIEETVEGGLSAFCPASALQMHPHATIIVDEEAASRLRHKDYYRYAYTHKPAWQGI
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: NU184_SCHPO
Sequence: MGDYLLSWSWILDAFETSDENLSQNKFEELLDARIAAFQQIESPVTGTLNSNKTTEGEEAKLSIYDSSHSISKSQLESVKKISDITGYNEAQVAYVLLVHQYELNTQYFSQLDNDSVLAQEFQRRYYAEIISCWKVLAFLLQACTDADSKWHKMATRLIVSIFQTAQRSGENAQSTTPSIFCVRIIDYLSKMTSQAAPASLTFNGEEAISQWYFFHFNLQLQLLRVIFLSTYSLVVCNSEMAISWFNCMKKTRYLHDQEFMHLDIDTGFSMCKEITNVAIIISINFISLEKQVLSFKDNPSFFMLSGNTIISLHDMITQLSNDSIGAAVSLTWGIALHLLSNSPDNIPLIQNSSVVSSKILQNPQNSFQALIIAALKYDPFTLIHRIISSLEDDPYIDGYSKIMATLFSSAVSYVKFSDSTMLCATTLFKTPQVYQLFENNDSVTRLLNFARARFPFEYSQFVLLLIPTFACLTSKQLVSSELLHMTTFTQSLPSGFKAYEIIPEPNVTGNALIELQESLHLDSYGFFFPNAERSLPKGTRGRIVSVDTYPPVVMWDLNYSLWEAVGISLNYIVRNGLINSHKSFVLTVLSSSVPLFQTDVSGACELVHLASEGLDGELDFINVICDLLDYFLSLSVIEDADYQICVSSLRLLREFTRFAATDVWAYVTRSLVCVGSEKGISLEDVIFDYESINGVYDFTLAFFDLYEILLDNCISTSVVPDDFSIRLKTDFVKRAMRFLCEVFANYLDWKYARIIQQYQIGHRFASLITKLLNVTFGIEYFNPKTTVNKKTLPLRELSHYIVQRFLVQQDSNRYLHPLLSVMDLINLLYTDIFSTISSPRAKAAKMWLISSFCAMKTLICLRGFLNLKPSELERELFSRSPDLFNCLPRLLCCIAPILQLLSALILAPWPSETPSLLAYMINSTDIVGRVCIQILTNPIQSTNIEGSVWKFLSSIMKGQQQGLAVLLFSGKKFPLDRMKSLNHNVDVQLTSKSLISLAEKRLDSFSINDILSQVPVFEFIFLSRNFWTASLGNLQQEANFWNRIVDAIKLPLTVKLDGLSSVAQADLYILAAHATRITAIQLHMSKLNKSNSSKKIIIDPLKDSMKDLVQHAFTITAYDSNIHNALTRAFKHENGDLHISDLRNTGLFPLRYGDNYFYNIKLAKNMLLNTEDTSFKISMMMSANENLSLLDAQAALLRSWSIFICAFVEFVKEDATLSILELKIMKWVLKSLAEDTIDVNVVQELSAERAALVFRISQQTLAIPISNEVKEHLQSILLLTWKAITTTKFSIYEDSNGEMAYYRPLLHVLYNTLNRLLSEEKENLSLSVGFVSGLLQLCHRKLSQLFEKAVINPTIEVYGDIVLLNSLHKCIVNSHLIRGLQSLYISYINDSFSVDNCLRLFSWSHSLLVDGQPYFADAALSFLLICSSSPAGAEQIVMNGFFYSIMESPLSTALSTGGLGLDGSSIQYKIWIRGILPLLFNIVKFLGNRIMNDMREFVLLAFPQIQYALLNWCQPPSSISLASIDESFMIVLLFDLLQQFNPALLQEIRLAELKIEMLEASTI
What is the function of this protein?
Interacts with pom152 in the core structure of the nuclear pore complex (NPC).  Involved in the export of mRNA.
What are the official names of this protein?
Nucleoporin nup184, Nuclear pore protein nup184.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex.
Protein: YIDD_CERSK
Sequence: MSPLAQVLALPVRAYRLLLSPWVGHGCRYQPTCSVYALDALERHGALKGGWLAARRILSCHPWGGSGYDPVPGADPEHDRRPRG
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL31_SHESH
Sequence: MKADIHPAYAEITATCTCGNVIKVNSTAGKALHLDVCGACHPFYTGTQKIVDTGGRIDKFNKRFGALGKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RL1_HAEIE
Sequence: MAKLTKKMKAIKAGVDSTKAYEINEAIAVLKQFATAKFVESVDVAVNLGIDPRKSDQNVRGATVLPHGTGREVRVAVFTQGANADAAKEAGADLVGMEDLAEQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKSGQIRYRNDKNGIIHTTIGKANFSEVQLKENLQALLVALNKAKPTTAKGIFIKKVSISTTMGAGVAVDQASL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: Y2705_PSYIN
Sequence: MSYIIDRRLNAKKKSTVNRQRFLKRYRKHIKKAVTDAISRRSITDLEHGEEIHIPAEDMKESFFHHGQGGHAKRVLPGNQDFIGGDRIERPPSGGAGGSGSGASDSGKGEDEFVFQITQAEFLDFMFDELALPNMIKRQLLGSDEFKLHQAGFSNQGSPGQVDVVRSLKSAHARRIALTLSKRKKLKALEKQLHLLVAKEPVLKNQVEIEQLREKISTLKSRVKRVPWLDDFDLKYHLRAKEPAPQAKAVMFCIMDVSGSMNQATKEIAKRFFILLYLFIQRNYQRTEIVFIRHHTVAMEVDEQEFFYSRETGGTIVSSALKLMQQIIEQRYPLGDWNIYAAQASDGDNWNNDSAVCKEILCKALLPKLQYFSYIEITPNAHQLLWHSYQQVKANFPDTFAMEQVVDAAEIYTVFREIFHKQVI
What are the official names of this protein?
UPF0229 protein Ping_2705.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: RP19_VACCC
Sequence: MADTDDIIDYESDDLTEYEDDEEEEEDGESLETSDIDPKSSYKIVESASTHIEDAHSNLKHIGNHISALKRRYTRRISLFEIAGIIAESYNLLQRGRLPLVSEFSDETMKQNMLHVIIQEIEEGSCPIVIEKNGELLSVNDFDKDGLKFHLDYIIKIWKLQKRY
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 19 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: LIPB_BRUMB
Sequence: MPTGKLRQKPPYAAIMTNSPVTPSTETQQPKRYARFLPQEADAPPVEWLITEGLTDYEEALAFMEARVQAIREGTASELVWLVEHPPLYTAGTSANAEDLLTPDRFPVFNTGRGGEYTYHGPGQRVAYVMLDLKRRREDVRAFVASLEQWIIETLAAFNIKGERREDRVGVWVVRPEKPRLADGSMCEDKIAAIGIRLRRWVSFHGIAINVEPDLSHYGGIVPCGISEHGVTSLVDLGLPVTMGDVDVALGKAFESVFGPRQTK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBCK_ECOLI
Sequence: MKKAIAYMRFSSPGQMSGDSLNRQRRLIAEWLKVNSDYYLDTITYEDLGLSAFKGKHAQSGAFSEFLDAIEHGYILPGTTLLVESLDRLSREKVGEAIERLKLILNHGIDVITLCDNTVYNIDSLNEPYSLIKAILIAQRANEESEIKSSRVKLSWKKKRQDALESGTIMTASCPRWLSLDDKRTAFVPDPDRVKTIELIFKLRMERRSLNAIAKYLNDHAVKNFSGKESAWGPSVIEKLLANKALIGICVPSYRARGKGISEIAGYYPRVISDDLFYAVQEIRLAPFGISNSSKNPMLINLLRTVMKCEACGNTMIVHAVSGSLHGYYVCPMRRLHRCDRPSIKRDLVDYNIINELLFNCSKIQPVENKKDANETLELKIIELQMKINNLIVALSVAPEVTAIAEKIRLLDKELRRASVSLKTLKSKGVNSFSDFYAIDLTSKNGRELCRTLAYKTFEKIIINTDNKTCDIYFMNGIVFKHYPLMKVISAQQAISALKYMVDGEIYF
What are the official names of this protein?
Uncharacterized protein YbcK.
Protein: GPMI_SYNJA
Sequence: MDAQSVAPVVLVILDGWGYREAPEGNAVLAARTPVVDSLWATYPHTLLQASGRAVGLPSGQMGNSEVGHLTLGAGRVVPQELVRISDAIETGSLFHEPLLVEVCHRLKEQGGRFHFIGLCSEGGVHSHIDHLYGLLKLAAQAGIPAYVHAITDGRDTLPRDGARVLAALEKELQWLGSGVIATLSGRYYAMDRDRRWERTQKAYEILTEDGPGCGRSAAEVMEDFYAQDITDEFIPPTRLAPGAVQSGDAVIFFNFRPDRARQLTQAFVCPDFSGFQRRLIPDLTFITMTQYDPTLPVQVLFKPQNLDHLLGQVVSEAGLKQLRIAETEKYAHVTYFFNGGIEQPFPGEDRILVQSPLVATYDQMPEMSAVEVTDKAIEAIARREYSLVVLNYANPDMVGHTGNFKATVRALETVDRCLGRLLAAVVDVGGTTLIVADHGNAELMWDEQGNPWTAHTNNPVPCILVEGERRKIPGRGGDVKLRSGGTLADVGPTLLEILGLPQPPEMTGQSLLQPAEYTILQRQPAPVGR
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: SYP_YERPS
Sequence: MRTSQYLLSTQKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRGEINSYKQLPLNFFQIQTKFRDELRPRFGVMRAREFLMKDAYSFHTTQESLQETYDAMYTAYSKIFSRMDLNFRAVLADTGSIGGSASHEFQVLAESGEDDIVFSTGSDYAANIEFAEALAPTEPRAPATEELRIVDTPNAKTIAELVEQFKLPIEKTVKTLLVHAHEESGHKLVALLVRGDHDLNEIKAEKLPQVAKPLTFASEEEIRAAIGAGPGSLGPVNLSLPVIADRSVAVMSDFGAGANIDGKHYFGINWERDLALPLVADLRNVVEGDISPDGKGTLQIKRGIEVGHIFQLGTKYSEAMKATVQGEDGRNQVMTMGCYGIGVSRVVAAAIEQNHDDRGIIWPDAIAPFQVAILPMNMHKSFRVKELAEELYTTLRSHGIDVILDDRKERPGVMFADMELIGVPHNIVIGDRNLDSEEVEYKNRRVGEKQMIKTSEIVEFLLSQIKR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMA1_MOUSE
Sequence: MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
What is the function of this protein?
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1.  Binds specifically and directly to substrates containing either a simple or bipartite NLS motif.  Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
What are the official names of this protein?
Importin subunit alpha-1, Importin alpha P1, Karyopherin subunit alpha-2, Pendulin, Pore targeting complex 58 kDa subunit, PTAC58, RAG cohort protein 1, SRP1-alpha.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CR7AB_BACUK
Sequence: MNLNNLGGYEDSNRTLNNSLNYPTQKALSPSLKNMNYQDFLSITEREQPEALASGNTAINTVVSVTGATLSALGVPGASFITNFYLKITGLLWPHDKNIWDEFMTEVETLIEQKIEQYARNKALAELEGLGNNLTIYQQALEDWLNNPDDPATITRVIDRFRILDALFESYMPSFRVAGYEIPLLTVYAQAANLHLALLRDSTLYGDKWEFTQNNIEENYNRQKKHISEYSNHCVKWYNSGLSRLNGSTYEQWINYNRFRREMILMVLDIAAVFPIYDPRMYSMETSTQLTREVYTDPISLSISNPGIGPSFSQMENTAIRTPHLVDYLDELYIYTSKYKAFSHEIQPDLFYWSAHKVSFKQSEQSNLYTTGIYGKTSGYISSGAYSFRGNDIYRTLAAPSVVVYPYTQNYGVEQVEFYGVKGHVHYRGDNKYDLTYDSIDQLPPDGEPIHEKYTHRLCHATAISKSTPDYDNATIPIFSWTHRSAEYYNRIYPNKITKIPAVKMYKLGDTSTVVKGPGFTGGDLVKRGSNGYIGDIKATVNSPLSQNYRVRVRYATNVSGQFNVYINDKITLQRKFQNTVETIGEGKDLTYGSFGYIEYSTTIQFPDKHPKITLHLSDLSNNSSFYVDSIEFIPVDVNYDEKEKLEKAQKAVNTLFTEGRNALQKDVTDYKVDQVSILVDCISGDLYPNEKRELQNLVKYAKRLSYSRNLLLDPTFDSINSSEENGWYGSNGIVIGNGDFVFKGNYLIFSGTNDTQYPTYLYQKIDESKLKEYTRYKLKGFIESSQDLEAYVIRYDAKHRTLDVSDNLLPDILPENTCGEPNRCAAQQYLDENPSSECSSMQDGILSDSHSFSLNIDIGSINHNENLGIWVLFKISTLEGYAKFGNLEVIEDGPVIGEALARVKRQETKWRNKLAQLTTETQAIYTRAKQALDNLFANAQDSHLKIDVTFAEIAAARKIVQSIREAYMSWLSVVPGVNHPIFTELSERVQRAFQLYDVRNVVRNGRFLNGLSDWIVTSDVKVQEENGNNVLVLNNWDAQVLQNVKLYQDRGYILRVTARKIGIGEGYITITDEEGHTVQLRFTACEVIDASNAFISGYITKELEFFPDTEKVHIEIGETEGIFLVESIELFLMEELC
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera.
What are the official names of this protein?
Pesticidal crystal protein Cry7Ab, 130 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryVIIA(b).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: OBG_DEHMC
Sequence: MFDRVEINIKAGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHKRVHKASNGEGGMGSRCTGHNGADLVIKVPVGTVATILEENGQKRVLADLAADGDRTLVAHGGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYDLILELKLIADVAIIGYPNVGKSSLLSLLTAAKPKVANYPFTTLSPVMGVIERPEGVFVMAEVPGLIENAHLGKGLGHDFLRHISRTRMVIHLLDGTSENPIDDMIKVNSELYLYDASLSERPQVVAINKIDDELVQLRREELKETFKEAGLEVFFISALTGEGVDVLLAKVAEKLDILKAADISETAPDHEVKIFRPAPKGKMGFRITRLEDGWQVEAPEIERIIEHSDIEDPEVRRQVMVLLKHRSVQQSLIKSGAVIGQKIITGRMEWYL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_MYCLE
Sequence: MRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLADRGSANPLLILNTLLGGISAAAGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLGLALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQILIYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNNYLAVVFCALAVDSVLALPTLF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_STRS7
Sequence: MAKPTRKRRVKKNIESGVAHIHATFNNTIVMITDVHGNALAWSSAGALGFKGSRKSTPFAAQMAAEAAAKSAQEHGLKTVEVTVKGPGSGRESAIRALAAAGLEVTAIRDVTPVPHNGARPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: GTPB8_DANRE
Sequence: MLRIKALAPLQTRVSCWLLVLQRGHRLASIKHVCQLSERKRQSLLYPFSDLEGHLFSQVNQAQFKIFHPSLEELRQAETLFTPSSKHVINYSTSAVRMDHVPILKQPEVCFMGRSNVGKSSLIRALFSLAPEVEVRVSKTPGHTKKLNFFTVGKAFTLVDMPGYGHMAPQDFVEMVEPYLQERHNLARTFLLVDASAGLQSTDLVAVEMFEEFNLPYVLVVTKIDRTRQGALLALALELQDFIKKQTTACFPQPFLVSSVQFSGIHLLRCFIAHVTGKQLLSAKQS
What are the official names of this protein?
GTP-binding protein 8.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.