PharMolix/UniProtQA huggingface dataset:
Protein: Y522_HAEIN
Sequence: MKKKVRVIPRTSWAATSLWTAQYKTISILLFALSILGIGDGLIVLSGLGSTPWTVLSQGIAIQTNFDIGWSSFLISCAVMLVWKPLKLRLGLGTLLNIIVIALFLGITTKILAPPTALFSRMIFCLIGILLYGFGTALYLTCHLGAGPRDGLMVGICQRFHLSINVVRSSLEISVCLLGFLLGGVVGLGTVLFATSIGSVVQFFLNIIARLPHIPYEK
What are the official names of this protein?
Uncharacterized protein HI_0522.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: US27_HCMVA
Sequence: MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTRLGVWLMCIVGTFLNVLVITTILYYRRKKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHPKLSREVVCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVELNRVRNNKRATCWVVIFWILAVLMGMPHYLMYSHTNNECVGEFANETSGWFPVFLNTKVNICGYLAPIALMAYTYNRMVRFIINYVGKWHMQTLHVLLVVVVSFASFWFPFNLALFLESIRLLAGVYNDTLQNVIIFCLYVGQFLAYVRACLNPGIYILVGTQMRKDMWTTLRVFACCCVKQEIPYQDIDIELQKDIQRRAKHTKRTHYDRKNAPMESGEEEFLL
What is the function of this protein?
Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling (PubMed:35061538).  May also function as a G protein sink to sequester G protein from the cell surface via internalization (PubMed:35061538).  Plays an important role in spread of HCMV via the extracellular route.
What are the official names of this protein?
G-protein coupled receptor homolog US27, HHRF2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Virion. Host cell membrane; Multi-pass membrane protein.
Protein: CRMB_MONPV
Sequence: MRSVLYSYILFLSCIIINGRDIAPHAPSNGKCKDNEYRSRNLCCLSCPPGTYASRLCDSKTNTQCTPCGSDTFTSHNNHLQACLSCNGRCDSNQVETRSCNTTHNRICECSPGYYCLLKGASGCRTCISKTKCGIGYGVSGYTSTGDVICSPCGPGTYSHTVSSTDKCEPVVTSNTFNYIDVEINLYPVNDTSCTRTTTTGLSESISTSELTITMNHKDCDPVFRAEYFSVLNNVATSGFFTGENRYQNTSKICTLNFEIKCNNKDSSSKQLTKTKNDTIMPHSETVTLVGDCLSSVDIYILYSNTNTQDYENDTISYHMGNVLDVNSHMPASCDIHKLITNSQNPTHL
What is the function of this protein?
Inhibits host immune defense by binding to host TNF and various chemokines in the extracellular space.  Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines).
What are the official names of this protein?
Soluble TNF receptor II, Cytokine response-modifying protein B, CrmB.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG002 family.
Protein: GNAO_DROME
Sequence: MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCATDTNNIQFVFDAVTDVIIANNLRGCGLY
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.
What are the official names of this protein?
G protein alpha o subunit, Guanine nucleotide-binding protein G(o) subunit alpha 47A.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein: HEM6_PSEPW
Sequence: MTSRTEAVKAYLLDLQDRICSALETEDGGARFVEDAWVREAGGGGRTRVIGDGKLIEKGGVNFSHVFGSGLPPSASAHRPELAGRGFEALGVSLVIHPHNPHVPTSHANVRFFIAEKEGEEAVWWFGGGFDLTPYYGNEEDCIHWHRVAEQACAPFGADVYPRYKAWCDRYFHIKHRGEPRGIGGLFFDDLNEWGFDTCFAFIRAIGDAYVDAYLPIVQRRKDTPYTAEQREFQEYRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKAAPGSEEARLTEYFLQDRDWLAH
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNGF_DEIRA
Sequence: MSAPPAPPPDRSAPPDRTDSAQTEPTRPLVRRARRARMWLEPGLGVKRWIFLFVVCTFVGAVAFLHFTWTGPLHPLATKWILWLNQFAEPGVFPLYAVGMVVMALALAGALYSITMISRAMLRGTGTAPETAVNVLYERKTLSRGMRVVTVGGGTGLSNLLTGLKTHSSNITAVVTVADDGGSSGRLREALDMVAPGDLTDCYAALSESPALARLLLHRFGRGEGLEGHTFGNLLLATLSEERGGLGTAMQDIHEILKVRGRVYPATTRPVTLVAELADGRTIRGESRFAEQIRPSRIERVRLEPENPSALTQVLEAVRDAEMIVLGPGSLFTSIIPALLIPDIARAVRESPAPVVYVASLMTEPGETDGLSLSDHVNAITRHLGRTPDWVLLSNSKIEPAVQRRYQQEGATVLTLDGAGRDLRGRVRFAPLIQAGTARHDPQKLAAALMQLWDGPPRRFSLPGQRD
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSPH1_BACC1
Sequence: MDVKRVKQILSSSSRIDVTYEGVPVWIESCDEQSGVAQVYDVSNPGESVHVNVTALEEK
What are the official names of this protein?
Small, acid-soluble spore protein H 1, SASP H 1.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.
Protein: SYL_ZYMMO
Sequence: MSESGFSQRFNPHVVDGRWQKKWEESGCFHAKDNSDRPHSYILEMFPYPSGRIHMGHVRNYTMGDVLARYYRMKGHEVLHPMGWDAFGMPAENAAMERKIHPREWTMSNIATMREQLKRIGFAIDWSRELATCEPSYYGQEQALFLDLYKAGLVYRKESAVNWDPIDNTVLANEQVIDGRGWRSGALVERKKLNQWFLKITEFADDLLDGLKDLDQWPEKVRSMQENWIGRSQGMQFHFNFEVAPEGFDKIEVFTTRPDTLFGASFVAIACDHPIAKALAEKNAALPEFIADCQKMGTAAEDIETAEKKGFDTGLSLVHPLNPELKLPLFVANFVLMDYGTGAVFGCPAHDQRDLDFALKYNLPVKRVVAPSEAESNEAIGDKADTRAGIMVNSSFLDGLSSEEAKKTVIARAEKEGWGKGTTVFRLRDWGVSRQRYWGTPIPIIHCDSCGAVPVPKDQLPVTLPDDINFDKPGNPLERHPTWKNVTCPKCGKPARRETDTLDTFVDSSWYFIRFASQPDDKPFDKATAEKWLPVGQYIGGVEHAILHLLYARFWTRALQSIGRLDIKEPFTGLFTQGMVTHETYKDPEGHWLSPEQIHKDEAGIFLTESGEKVTVGRVEKMSKSKKNVVEPAPILDQYGADAVRWFMLSDSPPERDLAWTEAGIEGCWRFMQRLWRVAAIASEEASAGIDKDLQHRLHCSIKEVGEAIEGLSFNKAIAKIHDLVNAIEKAKASATRKEAALTLFRLVAPMVPHLSEEAWHLLEKEGFVAEASWPEFDPALTVEDEITIAVQVNGKLRDTLTVARDMPKDEAEKLALASEKVIKMLEGRSPKKVIVVPNRLVNIVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LKA2C_MANHA
Sequence: MGNKFTNISTNLRNSWLTAKSGLNNAGQSLAKAGQSLKTGAKKIILYIPKDYQYDTDKGNGLQDLVKAAEELGIEVQKEESNDIAKAQTSLGTIHNVLGLTERGIVLSAPQLDKLLQKTKVGQAIGSTENITKGFSNAKTVLSGIQSILGSVLAGMDLDEALQNNSNELTLAKAGLELTNSLIENIANSVKTLDAFGDQINQLGSKLQNVKGLSSLGEKLKGLSGFDKTSLGLDIVSGLLSGATAALVLADKNASTSRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLSFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVVASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNPGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHLKADKLVQLDSANGIIDVSNSGKAKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLNINRVDSWKITDGEASSTFDLTNVVQRIGIELDNAGNVTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFVETGKALHEVTSTHTALVGSREEKIEYRHSNNRQHAGYYTKDTLTSIEEIIGTSHNDIFKGSQFNDAFNGGDGVDTIDGNGGNDRLFGGKGDDIIDGGDGDDFIDGGKGNDLLHGGRGDDIFVHRQGDGNDSITEAGGHDRLSFSDSNLKDLTFEKVNHHLVITNTKQEKVTIQNWFREEEFAKTVKNYVATRDEKIEEIIGQNGERITSKQVDELIAKGKDNKIDKNDLANVVNSYELLKNSRNVTNSLDKLISSVSSFTSSNDSRNVLATPTSMLDTSLSSLQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: GCH1_RHOPB
Sequence: MDALIKPLRAGKPDAKPADPKGTEFRPAELDPAEFLAAAVKPDQPRPSRGEAEQAVKTLLAYIGEDTAREGLLDTPRRVVEAYDELFQGYHQCPAEVLNRTFGETAGYDDFVLIRDMSFTSHCEHHVMPFYGKAHIAYTPVERVVGLSKLARLVDIFAHRLQTQEHLTAQIAAAVDEVLKPRGVAVMIEAEHTCMSVRGIAKQGAVTFTSRFTGMFRDNPAEQARFMSMIRGGR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: NHR71_CAEEL
Sequence: MMKDEYNSQECMVCSAPADGLHYGAISCRSCNAFFRRTVVEKAEYRCKHTNTCLIDPDGRCACRSCRFTKCIEAGMKIGAVQPRRDPTGSQKERRKRAGGVGEMMSMNNSPLERNGNSFSSDGPTSNSFIVDAIRTDYGFATPRRISTDYSNSPDRYRKYVKIELDDEPIPSTSSAPEKQSCQSSPNDDEQQEFNHLVYAFGEHQRMMQLSFSTFEQFLDEHSNGPKLRRMDPLDVSKLSAVELTGLLYWIEKQQPYGELPVEDRSSLLKRYSVRKLSLDHFYSASKHPEYCARGEFVMNNFTFVPADRTGFELPDDDPHQIQAKREHCRTFAPTFNRFWKNVIRPFVLMKVNDAEVVFLHIMLLWSVTNNEHVTEDTRKVMKQRRDWAMNRLFDWYNEHGTSDPPLRFGQMILLLGEIELICDMHCQDFQVAKLFEFCDMSKFWYETLCYAPCNTNVLKFDPNLLENLKRFTAISVMENNGGLRPFVKTEIKQDPVLYSSPEVIAPESCYNDYQTVDIPVDCNPHTEPVSMDPNLANIDPAVLVFNAHMLPSVMAPLPDDADYHRPQLYHTQSEEVMT
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-71.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOTA_BPT4
Sequence: MSKVTYIIKASNDVLNEKTATILITIAKKDFITAAEVREVHPDLGNAVVNSNIGVLIKKGLVEKSGDGLIITGEAQDIISNAATLYAQENAPELLKKRATRKAREITSDMEEDKDLMLKLLDKNGFVLKKVEIYRSNYLAILEKRTNGIRNFEINNNGNMRIFGYKMMEHHIQKFTDIGMSCKIAKNGNVYLDIKRSAENIEAVITVASEL
What is the function of this protein?
Required for the transcriptional activation of middle promoters.  Middle promoters are characterized by the presence of the conserved sequence [AT]3TGCTTNA (MotA box).  MotA binds directly to MotA boxes.
What are the official names of this protein?
Middle transcription regulatory protein motA.
Protein: PHNC_MYCMS
Sequence: MIVFNNVNKVWPNGKQVLKNINLEINKGELVAVIGLSGAGKTTLLKTINKINDISSGEILIDFDKTKEHYEVTKTRGKKLQKLRQKIGLMSQEYNNIANKTVLQNVLNARVSSQKGINKILGFFKREDKMIALNSLDKLNLLDYAYIRADNLSGGQQQRVALARTLAQQPFLIIADEPVSALDPILANQVMKDFKNINKKDGITVIINIHHVDLAKKYATRVIGLNNGEIVFDDVPSKLDAQAMKKIYGE
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RRP44_YEAST
Sequence: MSVPAIAPRRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNDRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDIDDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK
What is the function of this protein?
Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  DIS3 has both 3'-5' exonuclease and endonuclease activities.  The exonuclease activity of DIS3 is down-regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel.  Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by DIS3.  Plays a role in mitotic control.
What are the official names of this protein?
Exosome complex exonuclease DIS3, Chromosome disjunction protein 3, Ribosomal RNA-processing protein 44.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Nucleus, nucleolus.
Protein: NO66_CULQU
Sequence: MSKVSSIFDTPAPDPRPATTENGAAAKPAARKKKSPAAATKKQLIDQLIREMSQDEDNNDSVDQAPPAKKSRKKADSSGNNNTSKSSVKDKPAKPKKPKTAGLKIKLQDHRKHKEKLRKSLQGVENSRQAAASTSMLEASFNGDSLKDRSNHSTPVHHKGAKAAKKNKNKSHIMPLPLTFTPSKVVVKQEPKTPRRPTMLNVEASSGSLDSVEIGREKFSWVIGPSTTVDEFMAQFWEKKPFLVQRNDPTYYANLLSRGKIDEMLRNNNIEYTKNLDVTSYREGVRETHNPDGRALPPDVWAFYEEGCSIRMLNPQTYLPGVYEMNVKLQEFFHCMTGSNFYLTPPNSQGFAPHYDDIEAFVLQVEGRKHWKLYSPRTASEVLARVSSPNFTQEEIGVPILEVTLEPGDLLYFPRGIIHQASTVPGHHSLHVTMSVYQKNSWADLLELYLPHALSQAAENHLELRRGIPQDLHQHFGIVHSDNETPTRKDLIKKIKSLVDKIFSEEAIDVAVDQLAKRFQHDALPPLLTDQERAQTAYGANYAFNPDGTVPLQTAFTERTTIRLLRRNIVRLVNEENTLRLYYHTENSREYHEYEPNFLEVDQDAALGVELLVKIYPETVAIGALPVEDKVEFAKSLWEKGLIVARGE
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AP2A_BOVIN
Sequence: MLWKLTDNIKYEDCEDRHDGASNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK
What is the function of this protein?
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes.  AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.  They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.  AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.  Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation.  Associates with chromatin to the PITX2 P1 promoter region (By similarity).
What are the official names of this protein?
Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2.
What is the protein family that this protein belongs to?
Belongs to the AP-2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR4_IRIPA
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPRSGSDPKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPRDIITTKDKQRSKALIQNYIASSPHEELPNHLTIDPFQYKGLVNQIIDSKWIGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TXLNB_MOUSE
Sequence: MEINHPDQLSVEHPTPPGDSSSLNQNGPGKQDGERCSTSGQAPEQEGSLHPEKGAHDVAEELSRQLEDIISTYGSAASPRGKESTSETKEQPPNTEAPDNEDVDYEETTEEIDREPTAPEEPAAAKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQAPEEKLDFLFKKYTELLDEHRTEQKKLKLLLKQQAQTQREKDQLQSEHNRAVLARSKLESLCRELQRHNKTLKEETLQRAREEEEKRKEITSHFQTTLTDIQTQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEEAQELMQEAEERHRREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIQRLENLCRALQEERKELYKKIREAKMSEKEDQVQRTSEEEPEPSVSENEEVDAEEANSFQKAVENLATAFTILHHPEFTPDQPTERQLAVNGPQSGSDVTHQHPETARLNHPSLPADSGSPRPPVGAQAVAEGVCEATPAPTASCTPAEAELQSQGLPAENTPGPKPHKPEANTSGQAPLSPAQGSLSVVEAKYDISPSPESEGDSAVVPGCESREQPPPEVTDIPVGPSTGLPREPDACLNGVD
What is the function of this protein?
Promotes motor nerve regeneration.  May be involved in intracellular vesicle traffic (By similarity).
What are the official names of this protein?
Beta-taxilin, Muscle-derived protein 77.
What is the protein family that this protein belongs to?
Belongs to the taxilin family.
Protein: S27A4_HUMAN
Sequence: MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
What is the function of this protein?
Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213).  Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275).  Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:22022213, PubMed:24269233).  Plays a role in the formation of the epidermal barrier.  Required for fat absorption in early embryogenesis (By similarity).  Probably involved in fatty acid transport across the blood barrier (PubMed:21395585).  Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA.  Prevents light-induced degeneration of rods and cones (By similarity).
What are the official names of this protein?
Long-chain fatty acid transport protein 4, FATP-4, Fatty acid transport protein 4, Arachidonate--CoA ligase, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 4, Very long-chain acyl-CoA synthetase 4, ACSVL4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: DNAJ_DICNV
Sequence: MADKDLYAILGVCRTANQDEIKKAYRKLSMKWHPDRNPNNKEEAEEKFKEINKAYEILSDSQKRASYDRFGFDAANQGAAGGGFSGGNFSDIFGDVFGDIFGNVRQTNGARQTRGHDLAYKIELSLEEAIHGVEKQIRIATQVRCGECHGSGMNAKSKKKTCPTCNGAGQVRMQQGFFSIAQPCPTCHGRGEIIENPCNKCQGTGRVKDTRVLTVNIPAGVDNGDRIRLSGEGEAGELGAPAGDLYIEIFVRAHPIFERQGNDLYCKMPISFTTACLGGDLEVPTLNGRVKLSIPEETQTGKTFRLKGKGVQSVRSNSVGDLYCTVTIETPINLSKAQKELLMNFEQALNEGGKTHTPQAKGFFDNIKQFFDNL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1719_ARATH
Sequence: MKKIFITLLWLLFISSFLCSSSSAEDDVLCLQGLKNSLIDPSSRLSSWSFPNSSASSICKLTGVSCWNEKENRIISLQLQSMQLAGEIPESLKLCRSLQSLDLSGNDLSGSIPSQICSWLPYLVTLDLSGNKLGGSIPTQIVECKFLNALILSDNKLSGSIPSQLSRLDRLRRLSLAGNDLSGTIPSELARFGGDDFSGNNGLCGKPLSRCGALNGRNLSIIIVAGVLGAVGSLCVGLVIFWWFFIREGSRKKKGYGAGKSKDDSDWIGLLRSHKLVQVTLFQKPIVKIKLGDLMAATNNFSSGNIDVSSRTGVSYKADLPDGSALAVKRLSACGFGEKQFRSEMNKLGELRHPNLVPLLGYCVVEDERLLVYKHMVNGTLFSQLHNGGLCDAVLDWPTRRAIGVGAAKGLAWLHHGCQPPYLHQFISSNVILLDDDFDARITDYGLAKLVGSRDSNDSSFNNGDLGELGYVAPEYSSTMVASLKGDVYGFGIVLLELVTGQKPLSVINGVEGFKGSLVDWVSQYLGTGRSKDAIDRSICDKGHDEEILQFLKIACSCVVSRPKERPTMIQVYESLKNMADKHGVSEHYDEFPLVFNKQEA
What are the official names of this protein?
Probable inactive receptor kinase At1g27190.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.