PharMolix/UniProtQA huggingface dataset:
Protein: PFDA_IGNH4
Sequence: MSSANPSRPVEGVAEEKAQVGVEAKGGEEKVKLLQDELRSLLAQIEYLRDQIEAVNTVIDDLYASLEVLDYLTKEGKGKVVLVPIGAGNFIKAKIEDTNTVITSVGGRLSLEVPSDEAKKAIESRIAALEQVRLTLLRKLEELNRKVNELLPRVREEGGQ
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha, GimC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the prefoldin alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_LARHH
Sequence: MSKKDFYDVLGVNRDASDDDIKKAYRKLAMKYHPDRNPDSKDAEEKFKEAKEAYEILSDAQKRAAYDQYGHAGVDPQAGFGGAGGQQGFGGFGDAFADIFGDIFGGGARAGGGGGRNAVYRGSDLRYNLEITLEEAARGCEKQIRIPTMEECSHCHGSGAKPGTEPKTCPTCGGAGQVRMQQGFFSIQQTCPTCHGSGKQITDPCNICHGAGRVKSQKTLNVKIPAGVDDGDRIRLSGEGEPGTNGGPAGDLYVVTHIKPHAVFERDGMDLHCEMPISFATAALGGEIEIPTLDGAAKLRIPAETQSGQVFRLRGKGIKALRASQHGDLMCHVQVETPVKLTDRQKELLREFDAISQGAPAKHNPKAQSFMDKLKDFFGG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y568_RICFE
Sequence: MQYLISSLIFLIPSLGMVAGLSVAATVTIFLLMLFLRGINRHCERLKGAWQSHKAGLLRLLRQNLQFFLAMTIKTELLFTAWCFISCLFAIRPINSLATFIQVFILLFLGFTVSNCVPFGNRVQLKNSLILGILTAILLFFIEYSSHGFLTRTFKASFGLYMLDRGCALLSITSWVAIIILLSSGKRRHALMLYILVLYLLSISDSLASFLGFSIGGVIFILARLIKPIFFKLIAISLITGSLLFPVIAKQIEPRDLSEKYLATQPSAAHRLFIWHFVANKITLKPILGYGFASSKYIKVNNSEMINYNGEKWHPLPLHPHNNILQITLELGIIGLILFLCLVYKYLKQINNIKSSNFRAASYSCFINYYIIGMISYNIWQIWWISSGIWVLVLMKLLVKPDIVVDN
What are the official names of this protein?
Putative polysaccharide polymerase RF_0568.
What is the protein family that this protein belongs to?
Belongs to the O-antigen polymerase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PDRP_RICAE
Sequence: MTKLIIHLVSDSSVQTAKYTANSALAQFTSVKPKLYHWPMIRNLELLNEVLSKIEYKHGIVLYTIADQELRKTLTKFCYELKIPCISVIGKIIKEMSVFSGIEIEKEQNYNYKFDKTYFDTLNAIDYAIRHDDGQMLNELLEADIILIGPSRTSKTPTSVFLAYNGLKAANIPYVYNCPFPDFIEKDIDQLVVGLVINPNRLIEIREARLNLLQINENKSYTDFNIVQKECLEVRKICDQRNWPVIDVSTRSIEETAALIMRIYYNRKNKYNK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: CAZA2_DIDVI
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEEQVLITEHGDLGNGKFLDPKNRVSFKFDHLRKEATDPRPYEGENAIESWRHSVENAMRAYVKEHYPNGVCTVYGKTIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: KUP2_RHIWR
Sequence: MSSDAAAVADRDGSSPGHGGHAHGSLGAMVVGAVGVVFGDIGTSPLYAFRETFAGHHPLPPDELHILGVLSLIFWSMMLVVTFKYVAIIMRADNKGEGGSLALLALINRKSEGKRWGKGIILLGVFATALFYGDSMITPAISVLSAVEGLTTVEAGFAPMVLPIAVGILIALFMIQSRGTAKVGMLFGPIMMIYFTTLGVLGTWHIIGNPHVLIALNPWYAVRFFMEEGTLAFLAMGSVVLAVTGAEALYADMGHFGRRPIGLSWLVFVLPALMLNYLGQGAMILSQDMATALRTIHNPFFLLAPEMLRLPLVILATMATVIASQAVITGAFSVTQQAIQLGFIPRLRITHTSAGSIGQIYIPAINWGLMVMVILLVMSFRTSSNLAAAYGIAVTGAMAIDTCLIAVVLIHLWGWNKALAAPLIAVFAAVDIAYFGANLTKVPDGGWFPLLIGFIAFTLLTTWGRGRMLMINRLREAAMPVKVFVQSAVNSAVRVPGTAVFMTSQAQGVPHALLHNLKHNKVLHERVILLTVKIADAPYVPESHRVDFADLGQGFYRIVINYGFMEDPDVPAVLSRTRTCGPEFKMMDTSFFLARQTLLPSERPAMAIWREKLFAWMLRNAESAMEFFKLPTNRVVELGSQVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_ROSCS
Sequence: MQAKAVTKYVRISPTKVRPVMDLVRGKPVDRALAILRYLPHKAAREIARTIESARANATNNYDMAPDALVVKYIFADEGPAFKRIMPRARGRADRIRKRTTHITVIVDDGEEM
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CSRA_GEOUR
Sequence: MLVLTRKIGEAVTIGDQIRIMVVEVKGNQVRLGIEAPQDMRIYREEIYLQVQEENRHAADWNLTDLENAVSLLGSGDKE
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMDH1_DICDI
Sequence: MLFAPPNLETKELFWIIYILILIPKVFAKVMSVRELFPFFKWGFNIRRSNFLVPILSNNVIVTGEEAVQYEKPLPYIPQHNQQQQQKQQPSQDYIQQPQNDNNINSGKEQEQQQQQQQQQQQTPDITNQPTKTNKKIPIKELSNEEILIKLEKGEVLAYRLENELGDCSRAVEIRRMLLEKQLSKKIEPIPHEGFDFAKVQGQCCENVIGYVPIPVGTAGPIQLNGQLVTIPMATTEGCLVASTHRGCKAITESGGAKCTITSRGMTRAPVVRFSDIVKASEFVSWINDTDNYQALKAVFDSTSRFARLSAIKCTIAGRSVYIRFKCDTGDAMGMNMVSKGVEAVLEHLKIIFDDMTLLSISGNMCTDKKPSSINWTEGRGRSVVCEAMITGDVVQRVLKTNVQALVDLNIAKNLIGSAMAGSIGGFNAHASNIVTAIFLATGQDCAQNVESSNCITQMEACNDGQDLYITVTMPSIEVGTVGGGTSLPAQSACLDIIGVKGSSSSKPGANADQLAKTIASAVMAGELSLMSALSAGHLMKSHLQYNRAKTN
What is the function of this protein?
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis.  It is the rate-limiting enzyme of the sterol biosynthesis.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1, HMG-CoA reductase 1.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane.
Protein: COX1_PANBU
Sequence: WFFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWDTPMLWALGFIFLFTVGGLTGIILANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLHNTWTKIHFGVMFM
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUOH_CITK8
Sequence: MSWITPDLIEILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPTWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNNQADIWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWHGPFLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QAY_NEUAF
Sequence: MTLLALKEDRPTPKAVYNWRVYTCAAIASFASCMIGYDSSFIGTTLALPSFTKEFDFASYTPGALALLQSNIVSVYQAGAFFGSLFAFATSYFLGRRRSLIAFSVVFIIGAAIMLAADGQRRGVDPIIAGRVLAGIGVGGASNMVPIYISELAPPAVRGRLVGIYELGWQIGGLVGFWINYGVNTTMAPTRSQWLIPFAVQLIPAGLLFLGSFWIPESPRWLFANGRREEAIKVLCWIRNLEPTDRYIVEEISYIDADLQRYAREVGKGFWKPFLSLKQPKVRWRFFLGGMLFLWQNGSGINAINYYSPTVFRSIGITGTNTGFLTTGIFGVVKMVLTIIWLLWLVDLVGRRRILFVGATGGSLCMWFIGAYIKIAGPGTTKTEEAKLTSGGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDQNTRSLGQASAAANNWFWNFIISRFTPQMFIKMEYGVYFFFASLMLLSVVFIYFFIPETKSIPLEAMDRLFAIKSVHNANKILMDELNFDRNPEREQSSLDEKDRVTQTENAV
What are the official names of this protein?
Quinate permease, Quinate transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LGR5_HUMAN
Sequence: MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Protein: SNP29_PONAB
Sequence: MSAYPKSYNPFDDDGEDEGARPAPWRDARDLPDGPDAPADRQQYLRQEVLRRAEATAASTSRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLASQPNSRLKEAISSSKEQEAKYQASHPNLRRLDDTDPVPRGAGSAVSTDAYPKNPHLQAYHQKIDSNLDELSVGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQL
What is the function of this protein?
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes.  SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion.  SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane.  Also plays a role in ciliogenesis by regulating membrane fusions.
What are the official names of this protein?
Synaptosomal-associated protein 29, SNAP-29, Soluble 29 kDa NSF attachment protein, Vesicle-membrane fusion protein SNAP-29.
What is the protein family that this protein belongs to?
Belongs to the SNAP-25 family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Cell projection, cilium membrane; Peripheral membrane protein. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes.
Protein: VATB_METMA
Sequence: MAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRGQVLDSSADIVVVQVFEGTGGLDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRIVPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVRGQKLPIFSASGLPHNEIALQIARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIVTPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLATLYERAGIVKGAKGSVTQIPILSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPINVLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLRGLVAIVGKEALSERDTKFLEFADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: NCAP_IBVB
Sequence: MASGKAAGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKAKKLNTPPPKFEGSGVPDNENIKPSQQHGYWRRQARFKPGKGGRKPVPDAWYFYYTGTGPAADLNWGDTQDGIVWVAAKGADTKSRSNQGTRDPDKFDQYPLRFSDGGPDGNFRWDFIPLNRGRSGRSTAASSAAASRAPSREGSRGRRSDSGDDLIARAAKIIQDQQKKGSRITKAKADEMAHRRYCKRTIPPNYRVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVPSSHACLFGSRVTPKLQLDGLHLRFEFTTVVPCDDPQFDNYVKICDQCVDGVGTRPKDDEPKPKSRSSSRPATRGNSPAPRQQRPKKEKKLKKQDDEADKALTSDEERNNAQLEFYDEPKVINWGDAALGENEL
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the gammacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: ILVA_ECOLI
Sequence: MADSQPLSGAPEGAEYLRAVLRAPVYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLTEEQKAHGVITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGANFDEAKAKAIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQDAHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIAVEAEDSACLKAALDAGHPVDLPRVGLFAEGVAVKRIGDETFRLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNIRGERLAHILSGANVNFHGLRYVSERCELGEQREALLAVTIPEEKGSFLKFCQLLGGRSVTEFNYRFADAKNACIFVGVRLSRGLEERKEILQMLNDGGYSVVDLSDDEMAKLHVRYMVGGRPSHPLQERLYSFEFPESPGALLRFLNTLGTYWNISLFHYRSHGTDYGRVLAAFELGDHEPDFETRLNELGYDCHDETNNPAFRFFLAG
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA.
What are the official names of this protein?
L-threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: UXUA_ECO27
Sequence: MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIVEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAVRFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSR
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: HSCA_BUCAP
Sequence: MVFLKNKVKKKLILGIDFGTTYSLLASVQNERVVLLTDDKKRYLLPSIVNFNKKKPLIGWEAEKKIIKDPINTITSVKRLIGRSIDFIKKEFPILPYVIEDNKDGGILFHTNSGLVTPIDVTSEILKFLKEKSCEFFNKKIDATVITVPAYFDNLQRDSIKKAAISAKINLIRLLNEPTSAAVAYGLQLNTEGLVVVYDLGGGTFDISVLKLNKGIFEVLGTAGHANLGGDDFDTLLSKYIYKKLNLSNQCDNFFQSLLLKKAKEIKIKLTKYEKVEVNFFNWKGIIFRDEFNLIIKDLIQKTLFICSNLLKEIDLKIESIKEVIMVGGSTRVPLVYQEVKKFFRKSPLISINPDQVVAIGAAIQSDMLMKNTIQKRTILLDVTPLSLGIEVMGGFVEKIIFRNTPIPISKTKEFTTAKDNQTIIVIHILQGERELVKDCISLSRFILKDIPSKKAGVVRILVTFEIDTDGLISVKILEKFSHKEKKIQIENVTFLQNKNIHKIIKESTINAKEDYYLRVRKEKKIESKYILDLLNNALQEDRNLITSEELKKIKSHQIKLQKSIDEDDFFSMKLNLKKLEEVSKNFLSLRLKKNMDSFSIKNLSDEIT
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU (By similarity).
What are the official names of this protein?
Chaperone protein HscA.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MTNA_DESDA
Sequence: MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGCVLALREAQGPDWAARLEQGMERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTAFAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAGALATAGYGTALGVIRAAVEAGKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIAANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGETRLCPENVPVLNFAFDVTPAEYISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPLRDEDDAPDAEPDWSRERS
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: DVL24_ARATH
Sequence: MCIILHSCTARLPQAQNLQIELKQDQVQASFKSNEKKNSIFIKLVSEKPMLINRRVESSNLLHSNMGGFLAKKTNSNSKIRNSFTSKCTSLMKQQHARLCIIRLCATMLLRSYTDHDDY
What is the function of this protein?
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
What are the official names of this protein?
Small polypeptide DEVIL 24, Small polypeptide ROTUNDIFOLIA LIKE 11, Small polypeptide ROT-FOUR-LIKE 11.
What is the protein family that this protein belongs to?
Belongs to the DVL/RTFL small polypeptides family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: COAD_STRPQ
Sequence: MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMNEKT
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5B_SCHPO
Sequence: MAASIIPKEVSLDETGHIKLFNKFPFEGVEVKDISLVDYITIGNGQPLPHTAGRFQTKRFRKARCFIVERLTNSLMMNGRNNGKKLLATRIVKHAFEIIALLTDQNPLQVLVDAVAACGPREDSTRIGSAGTVRRQAVDVSPLRRVNQALALITIGAREAAFRNVKSISECLAEEIINAAKGSSNSYAIKKKDELERVAKSNR
What are the official names of this protein?
40S ribosomal protein S5-B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PRMA_ECOSE
Sequence: MPWIQLKLNTTGANAEDLSDALMEAGAVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMNDVVAILENHPLLGAGFAHKIEQLEDKDWEREWMDNFHPMRFGERLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTSLCLQWLDSLDLTGKTVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAERNGVSDRLELYLPKDQPEEMKADVVVANILAGPLRELAPLISVLPVSGGLLGLSGILASQAESVCEAYADSFALDPVVEKEEWCRITGRKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.