PharMolix/UniProtQA huggingface dataset:
Protein: VPS16_BOVIN
Sequence: MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELRDCLVAAAPYGGPIALLRNPWRKEKPASARPVLEIYSASGVPLASLLWKSGPVVSLGWSAEEELLCVQEDGVVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAHRFTLSANVGDLKLRRMPEVPGLXSAPSCWTTVCQDRVAHILLAVGPDLYLLDHAACSAVTPPGLAPGVSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWCSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPELDGVRVFSRSTHEFLHEVPVASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLPQAVQQCIEAAGHEHWPDMQKSLLRAASFGKCFLDRFPPDSFVRMCQDLRVLNAIRDYHIGIPLTYSQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILSGQNKRAEQLARDFRIPDKRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNEAEMSLVLSHCTGATDGATADKIQRARAQAQKK
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations.  Required for recruitment of VPS33A to the HOPS complex.  Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B.  The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 16 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS16 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome. Note=Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Protein: TILS_NEIG1
Sequence: MLFLYRDEAVLTLDAFEQCLKDCFPQGLNGKKTAVALSGGLDSVVLLHLLVCAGKRAGFVPEALHIHHGLSPRADDWADFCRNYCDMLGVGLETVKVCVEKNGLGIEAAARQKRYAEFAEKGFDVLALAHHRDDQIETFMLAVARGGGLRALAAMPAVRPLGENGIIWRPLLPFSRQDIWDYARKHGLPNIEDESNTDTAYLRNRFRHRILPELSAQIPHFGRHVLNNVRALQEDLALLEEVVVQDCRWVCGAGYFDTARWLTFSPRRKTHILRNFLKENGIPVPNQNALADIARVLTEAKTGRWNLQGFELHHYAGRLFVFASEQLAKPAFLKDGTISGNLKKILTEHRFVLKRHPFGLPEAMLEQDGILRTVAASDTLAVGGIHKNVKKILQGKRVLPFLRPIWPLVADSGNRPLALANCCADFQISVSDGILPVHPDFPILF
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y029_MYCBO
Sequence: MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETLAEAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR
What are the official names of this protein?
Uncharacterized protein Mb0029.
Protein: NOHD_ECOLI
Sequence: MEVNKKQLADIFGASIRTIQNWQEQGMPVLRGGGKGNEVLYDSAAVIKWYAERDAEIENEKLRREVEELLQASETDLQPGTIEYERHRLTRAQADAQELKNARDSAEVVETAFCTFVLSRIAGEIASILDGIPLSVQRRFPELENRHVDFLKRDIIKAMNKAAALDELIPGLLSEYIEQSG
What are the official names of this protein?
DNA-packaging protein NU1 homolog.
What is the protein family that this protein belongs to?
To phage lambda DNA packaging protein NU1.
Protein: RL20_MYCPA
Sequence: MARVKRAVNAHKKRRSILKASKGYRGQRSRLYRKAKEQQLHSLNYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAAGVEVDRKNLADIAIADPAAFTALVDVARAALPEDVNAPSDSGEAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: DHPR_PIG
Sequence: MAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASANVVVKMTDSFTEQADQVTAEVGKLLGTEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKDSGMPSGAAAIAVLPVTLDTPLNRKSMPHADFSSWTPLEFLVETFHDWIIEKNRPSSGSLIQVVTTQGKTELTPAYF
What is the function of this protein?
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
What are the official names of this protein?
Dihydropteridine reductase, HDHPR, Quinoid dihydropteridine reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: VPS36_ARATH
Sequence: MASGSSSIAIGGLFENAEVTTSGRPVLRRNEVECFLLSSIDIDSEDDPPRFTALRSGNLILTTHRLIWIPSQSNESVPSSIPLSAVTHIYSHKKSIKSMFHSPRIRFQADPGSIVVTIVFRGKGDFDGFLSKLWECWRGRAWEEEEKSESETSKSGSGTVAQGLYGNDGTVRMVGLAGILRKEQEQWESTDKSLQDAFQDLNALMSKAKEMVSLAEKMRQKLLSAPSSQNGSTDDEEMGSKEEMQQWMLSVGIISPVTKESAGALYHQELSRQLADFVRIPLEKAGGMISLTDMYYHFNRARGTELISPDDLWQACTLWEKFDVPVMLRKFDSGVMVIQNKSHSDEEVMSRIRMLVTKTETLRVGVTASDAALTLKIAPAMAKEHLLSAETKGLLCRDMSPDGLRFYFNLFPEIDPTNLHIVKEFGTYGEWIKATSLLSV
What is the function of this protein?
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 36, AtVPS36, ESCRT-II complex subunit VPS36.
What is the protein family that this protein belongs to?
Belongs to the VPS36 family.
What are the subcellular locations of this protein?
Endosome.
Protein: TM147_HUMAN
Sequence: MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWAALLARAVVTGLLALSTLALYVAVVNVHS
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522).  Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967).  Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967).  Regulates LBR localization to the nucleus inner membrane (PubMed:32694168).
What are the official names of this protein?
BOS complex subunit TMEM147, Protein NIFIE 14, Transmembrane protein 147.
What is the protein family that this protein belongs to?
Belongs to the TMEM147 family.
Protein: Y781_SACS2
Sequence: MTNESEVGVKKAAELLRQGATMLEEACPICKMPLFKLKNGDVVCPVHGKVYIVKSDDEEKIVKRNLQLDEIESILIDGLYLSAKKMKEDPLDSERIIQIIRYLDALERLRKIKINSSE
What are the official names of this protein?
UPF0148 protein SSO0781.
What is the protein family that this protein belongs to?
Belongs to the UPF0148 family.
Protein: Y415_BORBU
Sequence: METKISVLIIEYFAVKRKLISDLINSSPKLQVIATASNSKFATNKLKKHKPEVILMNLEENNIKDILFLEEKNSLNKTIPIVVTSSNQNLINIAASKGADDLILVSKNKKSHEIKKEQIINSLLAYGSISIKNKIACNKDMKTKNYERANFILNHKNDISSLNQLEEHAKEKTLNEKEIKKLKLRKFDIIAIGVSAGGPVALKSILPEIPESFPPIIIVQHMPKGFTEEFAKNLNNLCKISVKETTNNEILKQGYAYISSGGYHTKIKKIDGNYQIKTLDGKHINGHKPSIGVLFQSIAEIAKDKAIAIIMTGMGNDGSREIGDIKKAGGLTIAQDKESSMVFGMPKIAIKENNIDYIVPLSHMVKLLKAILINS
What are the official names of this protein?
Probable protein-glutamate methylesterase BB_0415.
Protein: RBTN1_MOUSE
Sequence: MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQVDYEEGHLNGTFESQVQ
What is the function of this protein?
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
What are the official names of this protein?
Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, LMO-1, T-cell translocation protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: DRG1_HUMAN
Sequence: MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK
What is the function of this protein?
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155).  Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155).  When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238).  Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition.  GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
What are the official names of this protein?
Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, Translation factor GTPase DRG1, TRAFAC GTPase DRG1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
Protein: STLP2_ARATH
Sequence: MANQSTETNQPSNMQTYGVPIYAADWIPEVDVRSKIIMDPEKSEDDDESSSSSSSSRSCIVLSGGGGEGRSGISNVILICRVDLNTNSLSEQPLGRLVVGSDLPYRMAVHPREGGLICALPNSCKLFHWEDIMSREDNQAGESEEVIKELRDVGQQLALAFNPEGSVLAAGAEDGTLRVFKWPSMNTLLNESQAHSSVKCLTFSESGQFLVSLGGPVCRVWDVNASAAVASLSKEKDEMFASCRFSVDSAGNEVLYIAANTERGGSIITCDTKLWKRKWSKPIKKNSISAFNVSADGKLLAIGTLEGDVLILESTRMQTIQVVKKAHLGLVTALTFSPDSRGLVSVSFDSRARLTMIEQKGDKPGVRWWLLVLLIVLLYVVAYYYMKAKGIIP
What is the function of this protein?
Required for the formation or budding of transport vesicles from the ER.
What are the official names of this protein?
SEC12-like protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein. Note=Endoplasmic reticulum and the early Golgi.
Protein: MSCL_CLOP1
Sequence: MWKEFKEFAMKGNVIDLAIGVVIGGAFGKIVTSLVNDIIMPVVGSLVGKVDFSNLYINLSGQQFNSLQEAQAAGAATINYGLFLNNLINFLIIAFSIFIVIKQINKLKNFTKKKEEVKVEATEKDCPYCYTKIDIKATRCPHCTSVLEEATN
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL34_MESHJ
Sequence: MKRTYQPNKRKHLKTHGFRARMSTADGRKILAARRAKGRKRLTVSDK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: NOSD_STUST
Sequence: MFKAQATFSRYSAAVSLLLLFSGAAQAAPQSITTLPLQPDGENRWRLPAGEYQGQFTIEQPMQLRCEPGAVIQSQGQGSSLLISAPDVLVEGCTLYEWGSDLTAMDSAVFILPAAERAQISNNRMRGPGFGVFVDGTRDVQVIGNEIDGDAGVRSQDRGNGIHLFAVSGARVLHNHVRNARDGIYIDTSNGNHLEGNVIEDVRYGVHYMFANENSLIDNVTRRTRTGYALMQSRKLTVTGNRSEQDQNYGILMNYITYSTITGNFVSDVQRGDTGGDSMISGGEGKALFIYNSLFNTIENNHFEKSSLGIHLTAGSEDNRISGNAFVGNQQQVKYVASRTQEWSVDGRGNYWSDYLGWDRNNDGLGDIAYEPNDNVDRLLWLYPQVRLLMNSPSIEVLRWVQRAFPVIKSPGVQDSHPLMKLPTEKLLTEKQEPTS
What is the function of this protein?
Required for the assembly of the copper chromophores of nitrous oxide reductase (PubMed:2170125).  Could be part of the ABC transporter complex NosDFY (Probable).
What are the official names of this protein?
Probable ABC transporter binding protein NosD.
What is the protein family that this protein belongs to?
Belongs to the NosD family.
Protein: GLYC_MOPEI
Sequence: MGQIVTFFQEVPHILEEVMNIVLMTLSILAILKGIYNVMTCGIIGLITFLFLCGRSCSSIYKDNYEFFSLDLDMSSLNATMPLSCSKNNSHHYIQVGNETGLELTLTNTSIINHKFCNLSDAHRRNLYDKALMSILTTFHLSIPDFNQYEAMSCDFNGGKISVQYNLSHSNYVDAGNHCGTIANGIMDVFRRMYWSTSLSVASDISGTQCIQTDYKYLIIQNTSWEDHCMFSRPSPMGFLSLLSQRTRNFYISRRLLGLFTWTLSDSEGNDMPGGYCLTRSMLIGLDLKCFGNTAIAKCNQAHDEEFCDMLRLFDFNKQAISKLRSEVQQSINLINKAVNALINDQLVMRNHLRDLMGIPYCNYSKFWYLNDTRTGRTSLPKCWLVTNGSYLNETQFSTEIEQEANNMFTDMLRKEYEKRQSTTPLGLVDLFVFSTSFYLISVFLHLIKIPTHRHIKGKPCPKPHRLNHMAICSCGFYKQPGLPTQWKR
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: SYP_STRPF
Sequence: MKQSKLLIPTLREMPSDAQVISHALMVRAGYVRQVSAGIYAYLPLANRTIEKFKTIMREEFEKIGAVEMLAPALLTADLWRESGRYETYGEDLYKLKNRDNSDFILGPTHEETFTTLVRDAVKSYKQLPLNLYQIQSKYRDEKRPRNGLLRTREFIMKDGYSFHHNYEDLDVTYEDYRQAYEAIFTRAGLDFKGIIGDGGAMGGKDSQEFMAITPARTDLDRWVVLDKSIASMDDIPKEVLEEIKAELAAWMISGEDTIAYSTESSYAANLEMATNEYKPSSKVAAEDALAEVETPHCKTIDEVAAFLSVDETQTIKTLLFVADNEPVVALLVGNDHINTVKLKNYLAADFLEPASEEEARAFFGAGFGSLGPVNLAQGSRIVADRKVQNLTNAVAGANKDGFHVTGVNPGRDFQAEYVDIREVKEGEMSPDGHGVLQFARGIEVGHIFKLGTRYSDSMGATILDENGRTVPIVMGCYGIGVSRILSAVIEQHARLFVNKTPKGDYRYAWGINFPKELAPFDVHLITVNVKDQVAQDLTAKLEADLMAKGYDVLTDDRNERVGSKFSDSDLIGLPIRVTVGKKAAEGIVEIKIKATGDSIEVNAENLIETLEILTKEH
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBA_HAMD5
Sequence: MNLKRISEAKLPTPWGDFLMIGFKELDKEQDHLALVLGDISTDAPVLSRIHSECLTGDALFSLRCDCGFQLKAAFKQICEEKRGLLIYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQLGFATDERDFTVCANIYKILDVKAIRLLTNNPEKIKILKKEGINVVQRVSLIVESNPNNQDYLSTKKNKMGHFFKK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: AB11G_ARATH
Sequence: MEIEASRQQTTVPVSVGGGNFPVGGLSPLSEAIWREKAPTEFVGDVSARLTWQDLTVMVTMGDGETQNVLEGLTGYAEPGSLTALMGPSGSGKSTMLDALASRLAANAFLSGTVLLNGRKTKLSFGTAAYVTQDDNLIGTLTVRETIWYSARVRLPDKMLRSEKRALVERTIIEMGLQDCADTVIGNWHLRGISGGEKRRVSIALEILMRPRLLFLDEPTSGLDSASAFFVTQTLRALSRDGRTVIASIHQPSSEVFELFDRLYLLSGGKTVYFGQASDAYEFFAQAGFPCPALRNPSDHFLRCINSDFDKVRATLKGSMKLRFEASDDPLEKITTAEAIRLLVDYYHTSDYYYTAKAKVEEISQFKGTILDSGGSQASFLLQTYTLTKRSFINMSRDFGYYWLRLLIYILVTVCIGTIYLNVGTSYSAILARGSCASFVFGFVTFMSIGGFPSFVEDMKVFQRERLNGHYGVAAFVIANTLSATPFLIMITFISGTICYFMVGLHPGFTHYLFFVLCLYASVTVVESLMMAIASIVPNFLMGIIIGAGIQGIFMLVSGFFRLPNDIPKPFWRYPMSYISFHFWALQGQYQNDLRGLTFDSQGSAFKIPGEYVLENVFQIDLHRSKWINLSVILSMIIIYRIIFFIMIKTNEDVTPWVRGYIARRRMKQKNGTQNTTVAPDGLTQSPSLRNYIATRTDGARRW
What is the function of this protein?
Required for the cuticle, root suberin and pollen coat development by controlling cutin and maybe wax transport to the extracellular matrix (PubMed:24112720, PubMed:20035035).  Involved in developmental plasticity and stress responses.  Together with ABCG9 and ABCG14, required for vascular development by regulating lipid/sterol homeostasis (PubMed:24112720).  May be a transporter of lignin precursors during tracheary element differentiation (PubMed:28921082).
What are the official names of this protein?
ABC transporter G family member 11, ABC transporter ABCG.11, AtABCG11, Protein CUTICULAR DEFECT AND ORGAN FUSION 1, Protein DESPERADO, Protein PERMEABLE LEAVES 1, White-brown complex homolog protein 11, AtWBC11.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Protein: MREP_FBNY2
Sequence: MARQVICWCFTLNNPLSPLSLHDSMKYLVYQTEQGEAGNIHFQGYIEMKKRTSLAGMKKLIPGAHFEKRRGTQGEARAYSMKEDTRLEGPWEYGEFVPTIEDKLREVMNDMKITGKRPIEYIEECCNTYDKSASTLREFRGELKKKKAISSWELQRKPWMGEVDALLQERDGRRIIWVYGPQGGEGKTSYAKHLVKTRDAFYSTGGKTADIAFAWDHQELVLFDFPRSFEEYVNYGVIEQLKNGIIQSGKYQSVIKYSDYVEVIVFANFTPRSGMFSEDRIVYVYA
What is the function of this protein?
Essential for the replication of all genomic viral ssDNA (trans-replication).  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the conserved sequence 5'-A[GT]TATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.
What are the official names of this protein?
Master replication protein, M-Rep, ATP-dependent helicase C2, Replication-associated protein 2, Rep2.
What is the protein family that this protein belongs to?
Belongs to the nanoviridea/circoviridae replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RPO6_THEKO
Sequence: MFRYTRFEKARIIGARALQIAMGAPVLIDVPEGITPLQAALLEFEKGVIPITVIRPS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_LACP7
Sequence: MTTQEFIDAIKGMTVLELNDLVKACEEEFGVSAAAGVVVAAAGPAEAAEEKTEFDVELTDVGANKVKVIKVVREVTGLGLKEAKDVVDGAPKVLKEAASKEEADDIKAKLEAEGAKVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: EMARD_RAT
Sequence: MEILTGDSITTCLSPLVHDLICNLGFELTEICDINSIVTQNGEVRWKAITDRVSYAELGHSLDYRQSVQRLGPVCEAIHLHISSLSRAQFETQYSPWYQWTTSPELFLEIYDALESSQSAAISLSVMKLASCLERALGDVFLLIGNECPFLLRDLLASAELAHVFGHAVMDVLKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCSALLLLTAGLGQLLKSYLHHTKVQLAHRPFVTLTNLEDVIVFPGVTDKVLSALETVMTKSSFLLKIMLPYWELAVSKFKSHRFADCTMLLLSQLEAGLRRVFATVNKCPDRLLTAESTILYTTFDEILAKHMSDGSINQLPCFLGEPAMDFLWDFLNYQEGPRIRDRLSHGEINIREFPKAAASQLLTFCLVLLLRFTEEDTLSELKEEAAIQLLVSLAERYRSRCHPAFQLQKQVLSCEKSLRMWPVLPLPEECCQEAGRSEGNSEACACNSLISKILCELCHYLPASACAINGLDGLPSEKWSQLLNELCNTRIPTLFCPKIVLEVLVVLRGISSQCQRVSDQVIASLQLRHRQWVEHTLRSRQRQNYVRMLSSVGLLCPVLSLILLLLALELVSVHAVHGKDAQERQQYLRFLKLILQYTENLVAYTSRQKNKWNEAVSLTRAVLLRIWTFSEKKQMLIHLTKNTNKVDTG
What is the function of this protein?
May play a role in neuronal migration during embryonic development.
What are the official names of this protein?
Endoplasmic reticulum membrane-associated RNA degradation protein, ER membrane-associated RNA degradation protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS5_HELPS
Sequence: MTERKGMEEINREEFQEVVVNIGRVTKVVKGGRRFRFNALVVVGNKNGLVGFGLGKAKEVPDAIKKAVDDAFKNLIHVTIKGTTIAHDIEHKYNASRILLKPASEGTGVIAGGSTRPIVELAGIKDILTKSLGSNNPYNVVRATFDALAKIKA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.