PharMolix/UniProtQA huggingface dataset:
Protein: YFBV_ECOUT
Sequence: MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTCYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYDVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YfbV.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CMAH_CRIGR
Sequence: KQTAETLLSLSPAETANLKEGINFFRNKTTGKEYILYKEKNHLKACKNLCKHQGGLFIKDIEDLDGRSVKCTKHNWKLDVSTMKYINPPGSFCQDELVVEMDGNDGLFLIELNPPNPWDSDPRTPEELAFGEVQITYLTHACMDLKLGDKRMVFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLDQSGVQLTNINVVPFGVWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPEKAALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVESHPSDKYIKETNIKNDPIQLNNLIKKNCDVVTWTPRPGATLDLGRMLKDPTDSQGIIEPPEGTKIYKDSWDFGPYLSTLHSAVGDEIFLHSSWIKEYFTWAGFKSYNLVVRMIETDEDFNPFPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVVRYVVKHGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPP
What is the function of this protein?
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions.  Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.
What are the official names of this protein?
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminate monooxygenase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the CMP-Neu5Ac hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_DEHM1
Sequence: MVQQYTRLNVADNTGAKKIMCINVLGGSRKLQAKVGDVIVAAVKKSSPDAQAKSGTVVKAVVVRITKPYARPDGSYIKFDDNAAVILNDKMEPKGTRIFGPVARELRDKKFTKILSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: IGF2A_XENLA
Sequence: MEQLSCKHRSSSVEAEAQLCRQTESRSTQLPRMSVMRHLFLLSITFLVYTLDSAKAYRATETLCGGELVDTLQFVCGDRGFYFSTNNGRSNRRPNRGIVDVCCFKSCDLELLETYCAKPTKNERDVSTAPATAIPPLSKQDLYHKHHHTKSSKYDIWQRKSIHRLRRGVPAIVRARQYRLLMEKAEEAEQALSHRPLTTLPITRPLRLQQASEPSHN
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Promotes anterior neural development (PubMed:11709186).  Acts as a ligand for integrin which is required for IGF2 signaling (By similarity).
What are the official names of this protein?
Insulin-like growth factor II-A, IGF-II-A, Insulin-like growth factor 2-A, xIGF-2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: URIP_LACLM
Sequence: MGENTVPQKSSDNVGSIVALMVALLVAIFAFQLNASMLSPALVTMQAQLHTTASSIALTQTIFFTAAALFALFLPRLADLIGRKKVLIGMLTLTMIGCLISGFATNVGILMIGRILQGAAGPVVPLCLIILHVKVRDEKRYAKLMAILTSINGGIAGVDALAGGWLVSHGGFRSVFFVMGITAALAILLVSFGTQESTAKDTPKMDWTGVILLVVAMGALLSAVNALQGSFGNLGLPNWLLASILALLGLICFVGFWQVEKRVNHPMVPIHYLKQRRTWGLLITTLLTMTGVFAIMNGIIPALGQDGKFGLGLGADMVSLVTLTPYALAGLFFGPVSGFLAARFGFAKVLRVGLLTTIIGIVLAVAGVLQPSIWLLLLVSTFIGITYAGITNIMLNGLGIVLSPEDNPGYLPGLNAGMFNLGAGLSFIILYAVPTVLHTSVGGSSSGYISGIVTGLILVIIAFFTSFLIPDSKDCKINLE
What is the function of this protein?
Responsible for the uptake of uridine and deoxyuridine.  Not involved in purine nucleoside uptake.
What are the official names of this protein?
Uridine/deoxyuridine transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS16_SALTO
Sequence: MAVKIRLLRMGKIRNPQYRIVIADSRTKRDGRAIEFVGIYQPKHDPSVIEVKSDRVQYWLSVGAQPSEAVQRLLEKTGDWQKFKGLPAPEPLKVAPERVDRKAAYEAEAKAAAGLAEAPTKPAKKAAKAEAAPKTDEAAPKTEEQAGAGSGEQG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: UREF_BURA4
Sequence: MTTTELVALLHLASPALPIGAFSYSQGFEAALDANLIRDADTARDWIASGLTDVLAHGELPFLAHQLARWHAHDADALARENAWFIASRESAELRRETEQMGWSLAQLCTSLEWGDAARRATLATISPIALPTAFTYAAAAHDASADAVLAAYAFGWVENQTSAALKAVPLGQLAGQRIIVALRGAIDAAVRRALATPPDAVNTFAPQLGILSARHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_ECO45
Sequence: MKIYLVGGAVRDALLGLPVKDRDWVVVGSTPQEMLDAGYQQVGRDFPVFLHPQTHEEYALARTERKSGSGYTGFTCYAAPDVTLEDDLKRRDLTINALAQDDNGEIIDPYNGLGDLQNRLLRHVSPAFGEDPLRVLRVARFAARYAHLCFRIADETLALMREMTHAGELEHLTPERVWKETENALTTRNPQVFFQVLRDCGALRVLFPEIDALFGVPAPARWHPEIDTGIHTLMTLSMAAMLSPQVDVRFATLCHDLGKGLTPPELWPRHHGHGPAGVKLVEQLCQRLRVPNEIRDLARLVAEFHDLIHTFPMLNPKTIVKLFDSIDAWRKPQRVEQLALTSEADVRGRTGFESADYPQGRWLREAWEVAQSVPTKAVVEAGFKGVEIREELTRRRIAAVAGWKEQRCPKPE
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: COAX_MYCLB
Sequence: MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAGAAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAFHKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPELHTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_PARD8
Sequence: MATAYQNLSEYDFNSVPDASEMNIGIVVAEWNKNITEKLLEGACNTLEKHGVKPENIVVKRVPGSFELTFGAKRLAETKELDAVIVLGCVVRGDTPHFDYVCSGVTQGITELNLMYDIPFIFGLLTTDTMQQSEDRAGGRYGNKGDEAAVTAIKMVNFSA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: YO12_BPL2
Sequence: MARSKKGKNLIYVLLGLVGLLAFFVLFVPTLTISASTPVWLENTITYATSFRDAFNVSGMVYMVILLGVLIAYLLLKYSKTRQNKDALKVVLAVVIAFAVYLLFTPALAAAFSDQVWLVDFSKLATDITSFIDTNNGFLTIIAGLGALTFFIVKKSK
What is the function of this protein?
May be a DNA-binding protein involved in virion nucleoprotein condensation.
What are the official names of this protein?
Uncharacterized 17.2 kDa protein, ORF12.
Protein: AROK_PSEF5
Sequence: MRNLILVGPMGAGKSTIGRLLAKELRLPFKDSDKEIELRTGANIPWIFDKEGEPGFRDREQAMIAELCGTDGVVLATGGGAVMREANRRALHAGGRVVYLHASVEQQVGRTARDRNRPLLRTADPAKTLRDLLEIRDPLYREIADLVVETDERPPRMVVLDILERLQQLPPR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAHM5_MOUSE
Sequence: MDAFQSILKFFLNQKTAIGYSFMALLTVGSERLFSLVAFKCPCSVENTAYGLVFLFAPAWVLLILGFFLNNKAWRLFTGCCMNPKKIFPRRRCCRFFYVLGHIILSSLVAPVMWLSVALLNGTFYECAMSGTRSTRLLEMICKGKPKECWEELHKVSCGKSSMAAMESEEVRLSLQAQSQILGWCLICSASFLSLLTTCYARCRSKVSYLQLSFWKTYAQREKEQLENKLLECANKLSERNLKCFFENKKPDPFPMPSFGAWEAASELHSFHQDREHYSTLHKVVDDGMEQTPQEEETTMILVGTAQSL
What is the function of this protein?
Pore-forming subunit of a voltage-gated ion channel.
What are the official names of this protein?
Calcium homeostasis modulator protein 5, Protein FAM26E.
What is the protein family that this protein belongs to?
Belongs to the CALHM family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NAGZ_ECOBW
Sequence: MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRAASRNRLVVAVDQEGGRVQRFREGFTRLPAAQSFAALSGMEEGGKLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPQKALAIASRFIDGMHEAGMKTTGKHFPGHGAVTADSHKETPCDPRPQAEIRAKDMSVFSSLIRENKLDAIMPAHVIYSDVDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRQELMDSARWKAISTRLNQLHERWQEEKAGH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDR2_CRIGR
Sequence: MEFEEDFSARADKDFLKMGRKSKKEKKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFDVHDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMMQTRGNEVELGSEADGSQSDTIASELTSEEFKSPSVRKSTCRSICGSQDQERRVSVKEAQDEDVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQAGAKRL
What is the function of this protein?
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
What are the official names of this protein?
Multidrug resistance protein 2, P-glycoprotein 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BOMS_ORIVU
Sequence: MSTISINLMSIIRNPLHSKSKRALINKHPSSSASRLVQPCRISSKIDTKPAEITRRSGNYEPSLWDFDYLQSLNTHHHYKKEEQLKREEELIVQVKMLLGTKMEAVEQLELIDDLKNLGLSYFFRDEIKKILTSIYNNSFENNNKVGDLYFTALGFRLLRQHGFNVSQRIFDCFKNEKGSHFDETLIGEDIKATLQLYEASFHLREGENTLELARQISTKYLQKMVDEGRINDENLSSWIRHSLDLPLHWRIQRLEARWFLDAYAVREDKNPLIFELAKLDFNIIQATQQEELKEVSRWWNDSCLAEKLPFLRDRIVEAYFWGVALFELLEFGYQRKITAIIIILVTAIDDVYDVYGTLDELQLFTDVIRRWNTQSIDQLPYYMQLCYMTLYNYVSNLGYEILKDRGINTIPHIHQSWVSLVEAFLKEEEWYESGYTPSLKEYLNNASISVGAIAVVIALELSIPNSTIHHRTRIDHRHKILHLSGLVSRLANDLGTAQHEMEKGNVPTAIQCYMKDTNASEEEAWEHVRFMIGEAWKRLNTAMAEADDCPFTEQAVEAAANFGRAAQFIYREGDGHGHFQIHQHVENLFFHPYV
What is the function of this protein?
Involved in the biosynthesis of monoterpenes natural products (Ref. 2).  Monoterpene synthase that catalyzes mainly the formation of (E)-beta-ocimene and minor amounts of other monoterpenes (e. g.  myrcene, (Z)-beta-ocimene, alpha- and gamma-terpinene) from geranyl diphosphate (GPP) (PubMed:20419468, Ref. 2).
What are the official names of this protein?
(E)-beta-ocimene synthase, chloroplastic, Terpene synthase 7, OvTPS7.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYP_BEII9
Sequence: MRLSRYFLPILRENPKEAEIVSHRLMLRAGMIRQEAAGIYAWLPLGFRVLQKVEQIVREEMDRAGAIELLMPTLQLADLWRETGRYDAYGPEMLRIKDRHERELLYGPTNEDMITEIFRAYVRSYRDLPKILYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDLDEEGARLSYNKMFVAYLRIYKRMGLTAIPMRAETGPIGGDLSHEFIILADTGESAVFCNKDVLDLPIPDEHTDYDGDLSPIIKQWTSLYAATEDVHDAARFESETPPEKRIERRGIEVGQVFYFGEKYSKPMRSLITGPDGSEKPFQGGSYGVGVSRLVGAIIEASHDEAGIIWPEAVAPFTVGLANLKVGDAATDAACAEIYERLEALGVDVLYDDTDDRPGGKFAKLDLIGLPYQIIVGPKGLAEGKIEMKTRATGARENLSIAAVIERFTT
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T1842_DICDI
Sequence: MTTIVEEEPLFYIVMLSIGSFFALGSIIIAVILILQHFIHYNKPNHQKYIVRIIMIAPIYAIHSLLSLFFKRQFWALFFDISRDCYEAYVLYCFFKLLICFLGGEEALKELLSKKDTQPLTWPLGYFFSFTPKKSFYRLSLGLVLQYAIIKPTLAIVAAILYYNNKYLEGDFSISQGYLWITVINNISVLIALYFLVMFYEVFQNELSPHSPILKFLVIKSVVFFLFWQTVVITVLIWFDALPKSDVYSSEHIGYFINDFLVCIEMFITSIAMGICFSYSDYVIDKSTHDEILGNGKRSSSRGIGSRSGRNIKISSKIKNIKNNFNRYRHNIGDGLSDVNNPKDIILDTIMVAKLNKNNNNTNNNEINNGIIDNNNSNNIENNGKSRNNIENNIDSQDYFNFIDLNTNDKEKQSKSKYFKIKMPDSDQSSLINLDQCESPSILYGSLNGASNNNNNNNNNNNNINNNNNNNSNNSNNNSNSQFESIDINSNSVNSNKNQSDAILFTF
What is the function of this protein?
Probable transporter.
What are the official names of this protein?
Transmembrane protein 184 homolog DDB_G0276041.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOAA_SALHS
Sequence: MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPGGVTNNGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDFTDIIAAVGENDAIRQIAVTTNGYRLARDAASWREAGLTGVNVSVDSLDARQFHAITGQDKFRQVMAGIDAAFDAGFKKVKVNTVLMRDVNHHQLDTFLAWIQPRPIQLRFIELMETGEGSDLFRKHHISGQVLRDELIKRGWIHQLRQRSDGPAQVFCHPDYVGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCLFGDGGVSLRDLLQDDAQQYALEERISDALREKKQTHFLHQSNTGITQNLSYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: CHM2A_XENTR
Sequence: MEFLFGRRKTPEEMLRQNQRALNKAMREMDRERQKLEQQEKKIIADIKKMAKQGQMDAVKIMAKDLVRTRRYVKKFIMMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMATMNRQLKLPQIQKIMMEFEKQSEIMDMKEEMMNDAIDDAMGDEDDEEESDAVVSQVLDELGLTLTDELSNLPSTGGSLSVAGAKKGEPSAALADADADLEERLNNLRRD
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 2a, Chromatin-modifying protein 2a, CHMP2a.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: PURA_RALPJ
Sequence: MSAPAVSQGRNVVVIGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMRDGVACYIGNGVVLSPEALFKEIDELESAGVQVQNRLRISEATNLILPYHVAIDKAREAKRGAAKIGTTGRGIGPAYEDKVARRGLRVQDLFDPAYFAERLRENLDFHNFVLTQYLNHPALDFQQTLDEMLSYAGRLAPMVTDVSAELFAANAAGKNLMFEGAQGTLLDIDHGTYPFVTSSNCVAGNAAAGAGVGPGQLHYILGITKAYCTRVGSGPFPSELYDADNPARQDPIGVRLANVGKEFGSVTGRPRRTGWLDAAALRRAIQINGVSGLCMTKLDVLDGLETLKLCVGYMLDGKQIDILPRGSDAVARCQPIYEEFPGWNTSTFGLKEWDALPQTAQAYLKRVEEVAGIPIAMISTGPDRDETILLRHPYKD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_WIGBR
Sequence: MHKPIKKLGQNFLKDKKIIKKIINFINPKYKDKIIEIGPGLGALTIPISKISKSITAIEIDKNLVYFLNKNKNIKNNLNIINIDIMKLNLKKFFSSFCDPVRIFGSLPYNISVSLMFNFIENYNKIIDMHFVIQKEVAQRILARPNNKHYGYISVIMQYYFYVEKLIDISNCAFKPIPKVQSSLIRMRPHKVCPFPFCDIDKMKVLLKSAFNQRRKMLKNSLKKYFSVEQIILYKINPKLRAENLSIENYCNLSNNMIIKK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_CHLMU
Sequence: MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQVAESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENASLAMLGKAKKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGYDALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECP40_DAUCA
Sequence: MADLRDEKGNPIQLTDQHGNPVQLTDEYGNPVHITGVATTGATTGHHDHGVGGASHGGVGSTGLGGVAGAAGLAGATAAAATHGGSHGGTGTHGVGPTGVGAAHGGTGTTTGLGTGTGTTGQTHGMGPTGIGGTHGVGSTGIGGAHGGTGVLGQTHGMGPTGTGAAHGGLGTGQSGLGSSYATHGGLGTGIGTGSAPASAGSHSHAPEKKTALGEQLHRSNSSSSSSEDDGQGGRRKKGFTTKIKEKLGGGKHKKDEHTTVATTKTTTAAHPGGAAVAVEHHEHEKKSMLDKIKDKLPGHHSPTSH
What are the official names of this protein?
Embryogenic cell protein 40, ECP40.
What is the protein family that this protein belongs to?
Belongs to the plant dehydrin family.
Protein: COX3_RAT
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS14_RICCN
Sequence: MAKVSSIKKNESRKKKSQSLHNKRLALKSKIYDKNISLEERFSLVMSLAQLPRNSSSTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGLVPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: GLG2_YEAST
Sequence: MAKKVAICTLLYSRDYLPGALTLAYQLQKLLKHAVVEDEITLCLLIEKKLFGDEFKPQEIALIRSLFKEIIIIEPLKDQEKSIEKNKANLELLKRPELSHTLLKARLWELVQFDQVLFLDADTLPLNKEFFEILRLYPEQTRFQIAAVPDIGWPDMFNTGVLLLIPDLDMATSLQDFLIKTVSIDGADQGIFNQFFNPICNYSKEVLHKVSPLMEWIRLPFTYNVTMPNYGYQSSPAMNFFQQHIRLIHFIGTFKPWSRNTTDYDDHYYQLWRSTQRELYSECHLSNYFTHLQLGNIETETNFYHEPPCLQDLLNHGKRENQKHVDLDITSVDRNASQKSTAEKHDIEKPTSKPQSAFKFDWESTDYLDRVQRAFPKPDT
What is the function of this protein?
Self-glucosylating initiator of glycogen synthesis.  Catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues.  These chains act as primers for the elongation reaction catalyzed by glycogen synthase.  Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.
What are the official names of this protein?
Glycogenin-2, Glycogen synthesis initiator protein 2, Glycogenin glucosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.