PharMolix/UniProtQA huggingface dataset:
Protein: RL6_BURA4
Sequence: MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQAINPLVNVANNDGTLNLSPVDESREANALSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGVKAETPTQTEIVIKGINKQQVGQVAAEVRGYRPPEPYKGKGVRYSDEVVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y1143_BRASO
Sequence: MAGHSQFKNIMHRKGRQDAMKSKLFGKLAREITVAAKLGTPDPAMNPRLRAAVVAARAENMPKDNIERAIKKALGGEGENYAEIRYEGYGPGGVAVIVEALTDNRNRAASDIRSFFTKSGGNLGETGSVSFMFDRVGIIEFDRSVASDDSVLDAAIEAGADDVISGEGGHEVYASPDSFHEVAKNLEAKFGEPRKAALTWKPQNTVAVDDETGEKLVKLMDLLNEHDDVQNVYANFEISDALMAKMGG
What are the official names of this protein?
Probable transcriptional regulatory protein BRADO1143.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PATL1_PONAB
Sequence: MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEALRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTITSLLQQLMNLPQSAATPAPSNPHLTAVLQNKFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR
What is the function of this protein?
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs.  Acts as a scaffold protein that connects deadenylation and decapping machinery.  Required for cytoplasmic mRNA processing body (P-body) assembly.
What are the official names of this protein?
Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b.
What is the protein family that this protein belongs to?
Belongs to the PAT1 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Protein: CYSK_STAAM
Sequence: MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDSIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
What are the official names of this protein?
Cysteine synthase, CSase, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: LIGB_SALEP
Sequence: MRLWKSMAWGILLWHSQSGALCPAWPPARAAEEITRLQQQLADWNDIYWKQGVSAVDDSVYDQLSARLVQWQRCVGQDVSSTPVSPPLNGTTMHPVAHTGVRKLADRQAVEQWMRGRSELWVQPKVDGVAVTLVYQNGKLTRAISRGNGLQGEDWTPKIRLIPSIPQTTQGALANAVLQGEIFLQREGHIQQRMGGMNARSKVAGMLMRQDNASALNSLGIFIWAWPDGPANMPERLSQLAKAGFSLTNKYTLAVKDASEVERARQSWLTSALPFVTDGVVIRMAKEPASQHWRPGQGDWLAAWKYPPVAQVAQVSAIQFSVGKSGKITVVASLVPVILDDKRVQRVNIDSVKRWEAWDIAPGDQILVSLAGQGIPRLDEVVWRSRERSKPVPPDSHFNSLTCFYASETCQEQFISRLVWLGSRSALGLDGMGEASWRALHQTHRFKHIFSWLALTSAQIANTPGFAKGKSEQIWRQFNLARRQSFTRWIMAMDIPLTQAALQASGDRSWEQLLMRTEQHWRQLPATGERRAGRVIDWRNNPQIKTLSRWLAAQHIPGFGS
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: HIS7_XYLFT
Sequence: MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPTYPQASFDGPNALMLQIFSSQGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIAHTLADAPRRAVVQRHTKETNIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLALGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFVFEGTFVRERVGDMPTELVPHFFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAEP_ECO45
Sequence: MEKYCELIRKRYAEIASGDLGYVPDALGCVLKVLNEMAADDALSEAVREKAAYAAANLLVSDYVNK
What are the official names of this protein?
UPF0253 protein YaeP.
What is the protein family that this protein belongs to?
Belongs to the UPF0253 family.
Protein: RS11_HELPG
Sequence: MAKRNVTAKKKVVKKNIARGVVYISATFNNTNITITDEMGNVICWSTAGGLGFKGSKKSTPYAAQQAVESALSKAKEHGVKEVGIKVQGPGSGRETAIKSVGATEGVKVLWIKDITPLPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ASTC_ECO55
Sequence: MSQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTLNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
What is the function of this protein?
Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate.  Can also act as an acetylornithine aminotransferase.
What are the official names of this protein?
Succinylornithine transaminase, Succinylornithine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
Protein: VP33_BPAPS
Sequence: MATFQLSGLPSLQIENQTVGGLGLPTVPQYAERPNTGVMLAQGLGAISERLEANKQQQSEADFMKSLGTAYAANDRDAMKQLAAAHPEQIERIQKGMGFIDQDRNQMIGQAAMDLRLAAKRGDQSLIASLQKNVPLLGQFGLTPEEVFLSYKQDPQQFDKMTDLIHLHADPKSYFDVQDKQEGRNIDRNKLAETERSNRAGETLTMRGQYISGANALTAAYAPTAAMQNYRQYAEMLQSDPDAAMAFANAAGINTVSKKLMKVEKNDDGSVTKYYTDGSEETGKINQPIAGDGIKPISLPHAQSIIDKANEGSKKAAGFALRLKDSMDSMHKLGKKIDTKRVALINRALGEGAIANLSLSPVEQQYMVNARDALYAILRPETGAAITLPEMQEYAKMYLPQPGDSTLATETKMKKMQGQYNALRGQSGRVYDALVVSSAAYNQRLQSDGRYTSKSGIQFKVE
What is the function of this protein?
Component of the phage injection machinery.  Required for injection of the phage DNA into the host (By similarity).
What are the official names of this protein?
Putative DNA transfer protein p33.
What is the protein family that this protein belongs to?
To phage P22 gp20.
Protein: RS17_THEAC
Sequence: MYTRNIGLDVKLPESECNDPHCPYHGKLSVRGQVLTGKVVSANMTKSAVVAREYQQYIPKYERKATKIKKYHVHVPDCIKIKPGDTVRFAECRKLAKTISFVIVEKVNQ
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PPNP_SALPK
Sequence: MLQSNEYFSGKVKSIGFTSSSTGRASVGVMAEGEYTFGTAEPEEMTVVSGALKVLLPGTVEWKVYTAGEVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: MIAB_THEYD
Sequence: MKGRAVYIKTFGCQMNEHDSERMLGILGTKGFIEVDEPKKADIVIFNTCAIRHKAEQKFFSSLGRVKHLKKKNPQLKIIVAGCSAQLQGEKLLNKLPYIDYIIGPDNLHVIENIIENQVSHRIFTDENPEVANINLPVKRKDCVKAWVNIIYGCNNYCTYCVVPYTRGKERSRPVDDIIKEISLLAEQGYKEVTLLGQNVNSYKDGNTNFPLLLEKVEKIEGIKRIRFITSHPKDLSKELVDVMKDYKKICEHIHLPLQAGSNKILKLMNRKYTYEEYFEKICWLREAIPDIAITSDIIVGFPQEQHEDFEKTINALKEIRFDGIFAFKFSPRLGTAAAKLDGHISEEVKAARLIEVLKLQDEITERKNKRLEGKIQEVLVEGKDEEGFTTGKTRTNKVVKIYSDIKAGEIVNVKIAKTHRHSLEGDIIST
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEJA_ECOLI
Sequence: MIVRILLLFIALFTFGVQAQAIKESYAFAVLGEPRYAFNFNHFDYVNPAAPKGGQITLSALGTFDNFNRYALRGNPGARTEQLYDTLFTTSDDEPGSYYPLIAESARYADDYSWVEVAINPRARFHDGSPITARDVEFTFQKFMTEGVPQFRLVYKGTTVKAIAPLTVRIELAKPGKEDMLSLFSLPVFPEKYWKDHKLSDPLATPPLASGPYRVTSWKMGQNIVYSRVKDYWAANLPVNRGRWNFDTIRYDYYLDDNVAFEAFKAGAFDLRMENDAKNWATRYTGKNFDKKYIIKDEQKNESAQDTRWLAFNIQRPVFSDRRVREAITLAFDFEWMNKALFYNAWSRTNSYFQNTEYAARNYPDAAELVLLAPMKKDLPSEVFTQIYQPPVSKGDGYDRDNLLKADKLLNEAGWVLKGQQRVNATTGQPLSFELLLPASSNSQWVLPFQHSLQRLGINMDIRKVDNSQITNRMRSRDYDMMPRVWRAMPWPSSDLQISWSSEYINSTYNAPGVQSPVIDSLINQIIAAQGNKEKLLPLGRALDRVLTWNYYMLPMWYMAEDRLAWWDKFSQPAVRPIYSLGIDTWWYDVNKAAKLPSASKQGE
What are the official names of this protein?
Uncharacterized protein YejA.
What is the protein family that this protein belongs to?
To H.influenzae HbpA.
Protein: RL30E_METST
Sequence: MDIERGIRVAVDTGKVILGSNKAIQAIKLGNGELAIMAENTPKNVKADIEAYSKLSEMPVYTFEGSSVELGSICGKPFTVSVLIIQEPGDSNILEIKE
What are the official names of this protein?
50S ribosomal protein L30e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: FTSZ_NEIMB
Sequence: MEFVYDVAESAVSPAVIKVIGLGGGGCNAINNMVANNVRGVEFISANTDAQSLAKNHAAKRIQLGTNLTRGLGAGANPDIGRAAAQEDREAIEEAIRGANMLFITTGMGGGTGTGSAPVVAEIAKSLGILTVAVVTRPFAYEGKRVHVAQAGLEQLKEHVDSLIIIPNDKLMTALGEDVTMREAFRAADNVLRDAVAGISEVVTCPSEIINLDFADVKTVMSNRGIAMMGSGYAQGIDRARMATDQAISSPLLDDVTLDGARGVLVNITTAPGCLKMSELSEVMKIVNQSAHPDLECKFGAAEDETMSEDAIRITIIATGLKEKGAVDFVPAREVEAVAPSKQEQSHNVEGMIRTNRGIRTMNLTAADFDNQSVLDDFEIPAILRRQHNSDK
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: FEMX_STAAN
Sequence: MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYILNQPLYQLIEQVKPRLTKAKIKISRKLKRK
What is the function of this protein?
Catalyzes the incorporation of the first glycine of the pentaglycine interpeptide bridge, which is characteristic of the S. aureus peptidoglycan.  This glycine is added to the epsilon-amino group of the L-lysine of the membrane-bound lipid II intermediate (GlcNAc-(beta-1,4)-N-acetylmuramic acid(-L-Ala-D-iGln-L-Lys-D-Ala-D-Ala)-pyrophosphoryl-undecaprenol), using glycyl-tRNA(Gly) as donor, in a ribosome-independent mechanism.  Involved in methicillin resistance (By similarity).
What are the official names of this protein?
Lipid II:glycine glycyltransferase, Factor essential for expression of methicillin resistance X.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H8Q01_CYRHA
Sequence: MVNMEASMFLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQEERDCAGYMRECKEKLCCSGYVCSSGWKWCVLPAPWRR
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1i, U3-TRTX-Hhn1i, Hainantoxin-VIII-17, HNTX-VIII-17.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLRX4_HAEI8
Sequence: METLDKIKKQISENPILIYMKGSPKLPSCGFSARASEALMHCKVPFGYVDILQHPDIRAELPTYANWPTFPQLWVEGELIGGCDIILEMYQAGELQTLLAEVAAKHA
What is the function of this protein?
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.
What are the official names of this protein?
Glutaredoxin 4, Grx4, Monothiol glutaredoxin.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. Monothiol subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_ALKMQ
Sequence: MKIAIDAMGGDHGARIIVLGAVEAVKEYDVNVILTGDEKILKSELSQYEYSKDKIEIIHCSEQIKNEDKPVAAIRRKKDSSMVVALNLVKEKKADAIVSAGNTGALLAGGLLILGRIKGIDRPALAPVYPTSKGVSVLIDGGANADCKPRNFLEFGIMGNIYANKVLGIEEPQVCTVNIGIEEGKGNDITKEAYKVCQRGPFQFKGNVEARDIPLGYADVILCDGFTGNIILKLTEGLATTIFSELKKAFLKNNITKIGALLLKPSLKIFKARFDYSEYGGAPFLGVNGVLIKAHGSSDAKAIKNAIRQGISFVNNDVVGDIVSEIESLEADFIE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: VGLG_VSIVM
Sequence: KFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTAIQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITQSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESL
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing clathrin-dependent endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane (By similarity).
What are the official names of this protein?
Glycoprotein G.
What is the protein family that this protein belongs to?
Belongs to the vesiculovirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: RECO_THEP3
Sequence: MGLLKTEAIVLKNNLIGETDKIATLFTKSYGKLQAVAKGARRSKSRFVNAIRPFIVANYVIFEGKNYYYIDQWELIEAHRNIEKDLVKFSVASYIAETINKILEENQKSERLYLFLKHSLKAVDELQIDPLIFISSYNLKLVSLLGYMPQLDNCVVCGKRENLKYFSNSCGGAVCINCKNKCFDAKPLHEVTLKAIKYFLKGDYDKLQNIKVSGVIKEEVDKIITAYMKEHLEIEFKSKDFIDNLQNM
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: HV404_HUMAN
Sequence: MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 4-4.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: TYB_GILMI
Sequence: MSDKPDVKEVESFDKTTLKKTTTNEKNTLPTKEVIEQEKSGGSD
What is the function of this protein?
Plays an important role in the organization of the cytoskeleton.  Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
What are the official names of this protein?
Thymosin beta.
What is the protein family that this protein belongs to?
Belongs to the thymosin beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: EFR3_DROME
Sequence: MALIRCCFEPPELPEFFDSFVQKCTDPSCCCGCCSALRPRYKRLVDNIFPVNPEDGLVKSNMEKLTFYSLSSPDKLDRIGEYLYQKATKDINRKRYKLAEIAMEAMDLLLQACHAQTTLNLFVESFLRMVQKLLEDSNPNLKIMATNSFVKFANINEDTPSYHRRYDFFISKFSSMCHSDAASMRDSLRLAGIKGLQGVIRKTVSDDLVENIWEAEHMEKIVPSLLFNMQFCVNVMFVKKNLLASGDLTPVEDATNVTPPALAEEVLRELVGRASFGHIRSVLKPLLTHLDRHELWVPNTFAIHTFRIVMISIQPQYSYTVVETLMQHLDNNFKSSPKTRTSLAVVLSKIIAIAAGESVGPSALDIINNLLTHLRTSVSTTSEITPEESQYQEALINALGEFANHHPDYQKIEIMLFIMNTVPDLSKKSKGDQMLQNILLKSLLKVGTQYSTVSFEKAFPASFLQPLLKMARAPHNPTRMVVMQILQALLDRHQNEQVLSSVSVKPYPALSQEPPSRSDIIFTHKYGANIMQALIDSMALSDRVDALTSSFNTAALLIVEMSCNETVQEFLLFILGIQQVACTVDTLGNVHKCSLHAISIGLLVLISRVSGINNLLEYAQKIVDARREEASHFLPPLLEPKKLAGKTFNLQLPHLAIDKLALGECLQNAGMDAQRLNTGAPYSLNQTDHPGHRHSWVESVSNQLTQRNSSADLTVYNGDVDSVSSSPGVCKKLLAPEFNFDAMKRALAEPTEAAKREQRERQMQIVRTFREGEFDDLMRRTEPKHDLIQNRLNELFNSLAVERQITQSDTKSSQLQASNEKPIYETNFPELFYY
What is the function of this protein?
An essential gene required for embryogenesis; required for cell viability.
What are the official names of this protein?
Protein EFR3 homolog cmp44E, Conserved membrane protein at 44E, Protein stambha A.
What is the protein family that this protein belongs to?
Belongs to the EFR3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SLAH3_ARATH
Sequence: MEEKPNYVIQVEEELPTLLRKATTEEMVGFDNYKENGHPFPHSISRFHPSHASTTTLNGQETSRSIDTMEAHHHNYNETTPWTHQRKPSISMPTSPNVLMISDPTTSLSSENHKNSGSTGKSVKFLSQPMTKVSSLYIESGNGDDDRRQSHDNHHHHLHRQHQSGHHQNQNQAANKLKDNRYNSFKTWSGKLERQFTRKPASVEPEAPNRNNQNLNTNEAMPVDRYYDALEGPELETLRPQEEIVLPNDKKWPFLLRYPISTFGMCLGVSSQAIMWKTLATAEPTKFLHVPLWINQGLWFISVALILTIATIYLLKIILFFEAVRREYYHPIRINFFFAPFISLLFLALGVPPSIITDLPHFLWYLLMFPFICLELKIYGQWMSGGQRRLSRVANPTNHLSVVGNFVGALLGASMGLREGPIFFYAVGMAHYLVLFVTLYQRLPTNETLPKDLHPVFFLFVAAPSVASMAWAKVTGSFDYGSKVCYFIAIFLYFSLAVRINFFRGIKFSLSWWAYTFPMTGAAIATIRYATVVKSTMTQIMCVVLCAIATLVVFALLVTTIIHAFVLRDLFPNDLAIAISNRPRPKQNSQHRWLDQLRNVSSENIENYLKFTDSDSSQSNDVEACNGKTQESDSS
What is the function of this protein?
Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis (PubMed:18305482).  Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity.  Functions as an essential negative regulator of inward potassium channels in guard cells.  Essential for the efficient stomatal closure and opening in guard cells (PubMed:27002025).
What are the official names of this protein?
S-type anion channel SLAH3, SLAC1-homolog protein 3.
What is the protein family that this protein belongs to?
Belongs to the SLAC1 S-type anion channel family.
Protein: RDRP_I45A0
Sequence: MDVNPILLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNVTKKMVTQRTIGKRKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRTQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.