PharMolix/UniProtQA huggingface dataset:
Protein: PANC_SHIDS
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQCQIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKIVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC1_SCHPO
Sequence: MLELKTNVIQDPELKDSLDLQENDRVEIIGDAVHYIVNDHLNRVFNYTVDQQKIHAALITTFASGKKAIVVILDDIGYVYYVGDNNNDSYIINVPFSTESAWSSPSGLYLQRHRSSDENLNTDLPHIFCLNDPLDELTLIKFDGKKILSLFDSIVYVVGEIVVTHNKKEKKLSFWRSRFIDPESDQSIKSSRNRRRESSFSREKNPDLTRSDSIHYTANTRLSEKFEEQGLAYSTIFSHIESFPITGSTSFDSILGNGVLVITTLVKELEKGYMMLFRLVRDRSPYFLDSLQLHAINLSAIKSKHLQKIVVLSSKGKVSLESPMSPSLPIEGTFRSFRVHGATLYLEDTDGVQRYISLDNRASNSLVKWCLSVIRYVLPLREYEIFYTGHLYALFAFKLSHDEAFISSILACFTFFSRDKVHVEPIEDCNEAYSLSSKFHFKKEILIASQLSSHLDYSTFKNYLMPLAITLHFISEELRLDSVVKPRKDQLVALLLQITTWLKWPRYCEYYNFDIAETFLSIPLSIQVDVEEPVGPTSILQWIIECLRSQSTVPFYGLESYGLPHSCSTMFPQTLSLMQLLDCLLNPNMTLQNLVEEMVRLGISRKRCERYPFGILCIIFTVLEIAAEEYSPNWESEELRLVNRLDVDSFLHPKTPKWVFNKQDQEVKEIKALTSTVTDSTLVDTQSFHPYKVVTDMIFREDRRLAEVNKLLNYSSQITIMTEHFDVDLSSVPMQQKVAQCICVRTLSVPIGAGMLTYGSKNPLPTEKVTPRLFNFTLHLHPGTLIIQPNKEFVTQELTEWPEFNVGVALGLSISKFSKEINTSWIMFNRPETLTAYHAGFLFGLGLNGHLKALATWHSFIYLTSKHDTTSIGLLLGLASSYLGSMDAKVTKLLSVHISALLPVGSNELNISPLTQTAGILGIGLLFHDSCHRRMSEVTMEEILASNESELKNEGYKLAAGFSLGLINLGRGSNLPGMSDLKLVSRLQVGISSQATFQSLEAGSPGAIMALTMIYMKTNDLEVAKKIDIPKSRYLLDFYRPDLILLRVAGKNLIMWDEVKADYEWVKYQIPDIMLSQFDLQEKKVLSSDDLLLYNVLAGICFSLGLRFAGTGNPKAKEILINFLDSFIRLCHLPAKTHDERVTAVTVIRCTQIVALSSSCVMAGYCDLDVLRRLRVLHGRMEPVNYGAQMATHMALGILSLGGGRYSLSRSNLAIAALLISFYPQFPRTTQDNRAHLQAARNLWALAVEERCIIPRNQDTKQPCIVPLNVVQKSGAVQKLEAPILLPPYDSISSVSTLGDKYWNLKIDLDNNSDYRELLRESQTLTLMPYDRTSSKEEPLNLFPKLKDTSSPLWNLVKTSRLFQSSNSPLNVASLQESNNKTSLGVKLLLSMDFDNLTRDRLLSLQILLQFFESCWTGVLLNKFHSRQYLFLSRDLVEDLSLRVWEYVYSHNHNEESV
What is the function of this protein?
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  Mutations to this protein prevent the exit from mitosis.
What are the official names of this protein?
Anaphase-promoting complex subunit 1, 20S cyclosome/APC complex protein apc1, Cell untimely torn protein 4.
What is the protein family that this protein belongs to?
Belongs to the APC1 family.
Protein: FEN1_THEPA
Sequence: MGIKGLIPFLSEKVPSSISELSLESLSGESLAIDASAALYQFTIAIRDSSYFSSLVNSKGESTSHIYGLMNRCSKFLEYGIKPVFVFDSKPPELKTKTLEKRRQQREEANASLKKAISEGDKESVKKLVGRTVKVSKEMNESAKKLLRLMGVPVIEALEEAEAQCAYLVTKNLCRFVASEDTDTLVFGGAFLLRNVASSSSKKILKVDLQKVLDGLEFNFDQFIDFCILCGCDYCDTLEGVGPKTAYSLVKKYQNLEEIVNFKGGDYDDFKEAKEYFLSPKVNEYDENSVKLGTIDPEGLTEFLVQENNFSKERVEKFIEKLLKFKTKKIQTSLLSFLTAPQHNNKAKSSNKRPREPKALDCKPNTYGSGKGTNVVKKESSTIKKDEIDLTAEDLFCEPSNSDNEEDDRGRVDKNEDLFKKSENETNEIKQNQFKSKSDEKKKQEEHHTIEFNFNHRKVILIDDDDDEVVTTANSEKMNCGKCLIYYFLQKLIK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NUDK_SALTY
Sequence: MSQTITLIKDKILSDNYFTLRNITYDLTRRNGEVIRHKREVYDRGNGATILLYNSTKKTVVLVRQFRVATWVNGNQDGMLIETCAGLLDNDEPEVCIRKEAIEETGYDVGEVRKIFELYMSPGGVTELIHFFIAEYHDSERASIGGGVEDEEIEVLELPFSRALEMVRSGEIRDGKTVLLLNYLQTSHLMD
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: YCF4_THEVB
Sequence: MTNSPITEPSPRQESVLRYPVLGSRRPSNYFWATAVSIGGLGFFLAGLSSYLHRNLLPIGNPIDLVFIPQGIAIGFYGVAALLLATYLWLAIAWDVGGGFNEFNKETGFVRIFRWGFPGKNRQIEVSCPISDVQAVKIVIKEGLNPKRSLYLKIKGRGEVPLTRVGAPLPLAELETQGATIASFLGVPVEGL
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: DOK1_BOVIN
Sequence: MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAASFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST
What is the function of this protein?
DOK proteins are enzymatically inert adaptor or scaffolding proteins.  They provide a docking platform for the assembly of multimolecular signaling complexes.  DOK1 appears to be a negative regulator of the insulin signaling pathway.  Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).
What are the official names of this protein?
Docking protein 1, Downstream of tyrosine kinase 1.
What is the protein family that this protein belongs to?
Belongs to the DOK family. Type A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y494_SHESR
Sequence: MKIVGDSEHFKQPYDSDEEYVSKTEDKRDCEAAQKVGMELVSLSKTQLDKIELDEHLYDSIQQAHKIKPKTEAYRRHMQYIGKLMRNVDVEPIKAALAIVLNKNNNETAKLQMFEKMRERLLSQGDSEIQTLVEHYPQLDRQKLRTLVRQATKELAKGPESKSSKELFKYLRSEIQD
What are the official names of this protein?
UPF0307 protein Shewmr7_0494.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: HBG_MACNE
Sequence: GHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKNLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIRFGKEFTPEVQASWQKMVAGVASALSSRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma, Gamma-globin, Hemoglobin gamma chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LNAB_ASPFN
Sequence: MSPDRKLITIFGGTGKQGGSVAHSLLQNPDFRVRVITRNAQSDASRKLAALGADIAQGDGFSGDEMLSAFSGSWGAFVNINSDDKIFTTEGGPTEFDMGKIIVDSAVQAGVKHLVFSSGPPCTEMTNGRVRMKAMDMKNKIEQYARSLGSFETFTPIGAGWFLENFLGKEVAPVFGGFPYFPDDQGYLTFRVPYWGGDEHVPWLSISDDFGDIVQGIFLDPGRWNGHFVHGVSDIRSFEQVVADFAAVTGNKARFQPILPTWEAFDTHGIQELEDVKLMFGFTQLTGGRYFGPEDTEVDTARQLKQITGLKLGRPEGQHKLTSARDWFAARFAN
What is the function of this protein?
NmrA-like family domain-containing oxidoreductase; part of the lna gene cluster that mediates the biosynthesis of diastereomeric piperazines.  Lna and lnb clusters encode sets of enzymes that produce overlapping sets of previously undescribed metabolites such as piperazinomycin-like metabolites or morpholine (PubMed:23281040).  The lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure (PubMed:23281040).  One primary function of the non-canonical nonribosomal peptide synthetases lnaA and lnbA consists in the reduction of L-tyrosine (PubMed:23281040).  The presence in the clusters of tailoring enzymes such as the oxidoreductases lnaB, lnbB, lnaE or lnbE, as well as of the cytochrome P450 monooxygenases lnaC, lnaD, or lnbC, might explain formation of various diastereomeric piperazines (PubMed:23281040).
What are the official names of this protein?
NmrA-like family domain-containing oxidoreductase lnaB, Lna diastereomeric piperazines biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: ESSD_ECOL6
Sequence: MKSMDKLTTGVAYGTSAGSAGYWFLQLLDKVTPSQWAAIGVLGSLVFGLLTYLTNLYFKIKEDKRKAARGE
What are the official names of this protein?
Lysis protein S homolog from lambdoid prophage DLP12.
What is the protein family that this protein belongs to?
Belongs to the lambda phage S protein family.
Protein: PMT1_ARATH
Sequence: MRGRSEGGKKKPVIVLLCVASVVLVFVYLFFGSSNHKAIEYGRKLGLGGDDDDSTKKDDTSSSFYVEDVVGNGFTPRSFPVCDDRHSELIPCLDRNLIYQMRLKLDLSLMEHYERHCPPPERRFNCLIPPPPGYKIPIKWPKSRDEVWKVNIPHTHLAHEKSDQNWMVVKGEKINFPGGGTHFHYGADKYIASMANMLNFPNNVLNNGGRLRTFLDVGCGVASFGGYLLASEIMTMSLAPNDVHQNQIQFALERGIPAYLGVLGTKRLPYPSRSFELAHCSRCRIDWLQRDGILLLELDRVLRPGGYFAYSSPEAYAQDEEDLRIWREMSALVGRMCWTIAAKRNQTVIWQKPLTNDCYLGREPGTQPPLCNSDSDPDAVYGVNMEACITQYSDHDHKTKGSGLAPWPARLTSPPPRLADFGYSTDIFEKDTETWRQRVDTYWDLLSPKIQSDTVRNIMDMKASMGSFAAALKEKDVWVMNVVPEDGPNTLKLIYDRGLMGAVHSWCEAFSTYPRTYDLLHAWDIISDIKKRGCSAEDLLLEMDRILRPSGFILIRDKQSVVDLVKKYLKALHWEAVETKTASESDQDSDNVILIVQKKLWLTSESLRDLE
What are the official names of this protein?
Probable methyltransferase PMT1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: TTCA_FRATM
Sequence: MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKALSNISPSQMLDKELFDFINISKDDIQR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1718_STRE4
Sequence: MKLPKEGDFITIQSYKHDGRLHRTWRDTMVLKTTENALIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGVSYYCNLASPYLMDAEALKYIDYDLDVKVFADGEKRLLDVDEYEMHKQEMHYSPNLDFILKENVKLLVDWINKEKGPFSKAYVSIWYKRYLELKNR
What are the official names of this protein?
UPF0374 protein SEQ_1718.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: AKTP1_DROGR
Sequence: MTLDLDAQKKDEKLLLATIQQEYKILAEYKMIESEKLSGIYVIPSYANSLQWFGVFFGRHGFYEKSVFRFSILLSDGFPDDKSVPAIVFQHNVVHPLVCPYTYSLDLSHAFHEWRPAEDHLWQVLKYMQAIFADPLESIRNVSTVHERSNAEIIKLLNNNRDAYAALVQESILESKAHIYDNPHTEDPHYIIFEKFQDDIHGPVLEQIRQNRATVGSTESGGGGGAATGLSWVKFKEGEFKPLSIE
What are the official names of this protein?
Protein crossbronx.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
Protein: Y978_CUPMC
Sequence: MLIVLSPAKSLDYETPPRVKSHTLPRFIDRSATLIERLRKLAPQDVASLMDISDKLAVLNVTRYADWSPEFTAANSKQAVLAFNGDVYDGLDAKTLSTDDLAFAQKHIRILSGLYGVLRPMDWMQPYRLEMGTRLDNAAGKDLYAFWGDDVTALINKDMAELKHEGSLTLVNLASEEYFKVVRPKVLAARVITPVFEDWKGGRYKIISFHAKRARGTMARYAVTHRVTDPAQLKRFNEDGYAFDKAASDDARWVFRRRLED
What are the official names of this protein?
UPF0246 protein Rmet_0978.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RBFA_MARMS
Sequence: MAGEFSRTSRIGDQLQKELASLIQFEVKDPRLGLVTVNEVRVAKDLGYADIYYTVLGKDDQPEVLAENQAALDSAKGFLRRRLAQEVKLRVMPHLRFHYDQSVVNGSRMSALIDEAIRDDETKNGNEDE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_PORGI
Sequence: MNFVEELRWRGMIHDIMPGTEEHLNKGMTSAYVGIDPTADSLHIGHLVGVMMLRHFQRAGHRPIALIGGATGMIGDPSMKSAERVLLDEATLRHNQDCIKQQLAKFLDFDSDAPNAAKLVNNYDWMKDYSFLGFIRDIGKHITVNYMMAKDSVKKRLSAESSTGLSFTEFSYQLLQGYDYLYLYRNEGCRLQMGGSDQWGNITTGTELIRRKDGGEAFALTCPLITKADGGKFGKTESGNIWLDPARTSPYAFYQFWLNVSDADAEKYIKIFTGLNQDEIAELASRQAEAPHLRPLQKRLAEEITVMVHSREAYDAAVEASEILFGKSTTEQLRKLDEATLLDVFAGVPQYHVERSRIATGISLVDLLADATDIFPSKGELRKTVKAGGVSLNKEKVADAEQTVGEDDLLSDRYLLAQKGKKSYYLIIVE
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCDH_BOVIN
Sequence: MALRGVYAQLLNRGPGLRVFRSWSSATAQTEKGEKTQSRSAKPSRPEFDWRDPLLLEEQLTADEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGMLGPTIQGYSCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMYPIYAYGSEEQKQKYLPRLAKGELLGCFGLTEPNHGSDPSGMETRARHNPSSRSYILSGSKTWITNSPVADLLIVWARCEDSCIRGFLLEKGMRGLSTPRIEGKFSLRASSTGMIIMDDVEVPEENVLPGVSGLAGPFGCLNNARYGITWGVLGAAEFCLHTARQYTLDRIQFGVPLAKNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHVMNLESVNTYEGTHDIHALILGRAITGIQAFVAGK
What is the function of this protein?
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism.  It uses electron transfer flavoprotein as its electron acceptor (By similarity).
What are the official names of this protein?
Glutaryl-CoA dehydrogenase, mitochondrial, GCD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: 4OT_COMTE
Sequence: MPFAQIYMLEGRSEEQKKAVIEKVTRALVEAVGAPSANVRVWIHDVPKENWGIAGVSAKELGR
What is the function of this protein?
Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate.
What are the official names of this protein?
2-hydroxymuconate tautomerase, 4-oxalocrotonate tautomerase, 4-OT.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: PLM5_PLAF7
Sequence: MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENKNDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTGSSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEGSQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPTFVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNVSIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKELDMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDFKTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCKGLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIFLKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
What is the function of this protein?
During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence (PubMed:20130643, PubMed:20130644, PubMed:24983235, PubMed:30127496, PubMed:30517136).  Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR (PubMed:20130643, PubMed:20130644, PubMed:23387285, PubMed:25447707, PubMed:25986559, PubMed:24983235).  Also, by regulating protein export, plays an essential role in gametocyte development and thus, parasite transmission to the mosquito vector (By similarity).
What are the official names of this protein?
Plasmepsin V, PfPMV, Plasmepsin 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=During gametogenesis, localizes to the perinuclear ER in stage I-II gametocytes, and relocalizes towards the cell periphery as the ER redistributes in the cell in stage III-IV gametocytes (By similarity). Partially colocalizes with SPC25 in the endoplasmic reticulum (PubMed:30127496).
Protein: SPIKE_CVPIA
Sequence: MFFILLITLPSVFAVIGDLKCNTSSINDVDTGVPSISSEVVDVTNGLGTFYVLDRVYLNTTLLLNGYYPISGATFRNVALKGTRLLSTLWFKPPFLSPFNDGIFAKVKNSRFSKHGVIYSEFPAITIGSTFVNTSYSIVVKPHTSFINGNLQGFLQISVCQYTMCEYPQTICHPNLGNQRIELWHHDTDVVSCLYRRNFTYDVNADYLYFHFYQEGGTFYAYFTDTGFVTKFLFKLYLGTVLSHYYVMPLTCDSALSLEYWVTPLTTRQFLLAFDQDGVLYHAVDCASDFMSEIMCKTSSITPPTGVYELNGYTVQPVATVYRRIPDLPNCDIEAWLNSKTVSSPLNWERKIFSNCNFNMGRLMSFIQADSFGCNNIDASRLYGMCFGSITIDKFAIPNSRKVDLQVGKSGYLQSFNYKIDTAVSSCQLYYSLPAANVSVTHYNPSSWNRRYGFINQSFGSRGLHDAVYSQQCFNTPNTYCPCRTSQCIGGAGTGTCPVGTTVRKCFAAVTNATKCTCWCQPDPSTYKGVNAWTCPQSKVSIQPGQHCPGLGLVEDDCSGNPCTCKPQAFIGWSSETCLQNGRCNIFANFILNDVNSGTTCSTDLQQGNTNITTDVCVNYDLYGITGQGILIEVNATYYNSWQNLLYDSSGNLYGFRDYLSNRTFLIRSCYSGRVSAVFHANSSEPALMFRNLKCSHVFNYTILRQIQLVNYFDSYLGCVVNAYNNTASAVSTCDLTVGSGYCVDYVTALRSRRSFTTGYRFTNFEPFAANLVNDSIEPVGGLYEIQIPSEFTIGNLEEFIQTSSPKVTIDCATFVCGDYAACRQQLAEYGSFCENINAILIEVNELLDTTQLQVANSLMNGVTLSTKIKDGINFNVDDINFSSVLGCLGSECNRASTRSAIEDLLFDKVKLSDVGFVQAYNNCTGGAEIRDLICVQSYNGIKVLPPLLSENQISGYTSAATAASLFPPWTAAAGVPFYLNVQYRINGLGVTMDVLSQNQKLIASAFNNALDSIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEILSRLDALEAKAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAIEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPTKYVTAKVSPGLCIAGDIGISPKSGYFINVNNSWMFTGSGYYYPEPITQNNVVVMSTCAVNYTKAPDLMLNTSTPNLPDFKEELYQWFKNQSSLAPDLSFDYINVTFLDLQDEMNRLQEAIKVLNHSYINLKDIGTYEYYVKWPWYVWLLICLAGVVMLVLLFFICCCTGCGTSCFKKCGGCFDDYTGHQEFVIKTSHDD
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: KATIP_HUMAN
Sequence: MDGQTLRKAERSWSCSREKKEGYAKDMVTDFDEKHDEYLILLQQRNRILKHLKSKDPVQLRLEHLEQGFSVYVNGANSELKSSPRKAIHSDFSRSASHTEGTHDYGRRTLFREAEEALRRSSRTAPSKVQRRGWHQKSVQIRTEAGPRLHIEPPVDYSDDFELCGDVTLQANNTSEDRPQELRRSLELSVNLQRKQKDCSSDEYDSIEEDILSEPEPEDPALVGHPRHDRPPSSGDWTQKDVHGEQETEGRSSPGPDTLVVLEFNPASKSHKRERNLSAKRKDNAEVFVPTKPEPNLTPQAPAVFPDQERMCSRPGSRRERPLSATRKTLCEAEYPEEDASAVLQAIQVENAALQRALLSRKAEQPASPLQDAEGPPAKPWTSLLEEKEETLELLPITTATTTQEPAGAAGGARAINQAMDRIGLLGSRQQQKLLKVLQAVESDSAHLGRVVSPTKEQVSDTEDKQRMRADEIKDAIYVTMEILSNWGNSWWVGLTEVEFFDLNDTKLYVSPHDVDIRNTATPGELGRLVNRNLAGKKDSSPWTCPFHPPLQLFFVIRNTRQLGDFHLAKIKVRNYWTADGDLDIGAKNVKLYVNRNLIFNGKLDKGDREAPADHSILVDQKNEKSEQLEEAMNAHSEESKGTHEMAGASGDKELGLGCSPPAETLADAKLSSQGNVSGKRKNSTNCRKDSLSQLEEYLRLSAVPTSMGDMPSAPATSPPVKCPPVHEEPSLIQQLENLMGRKICEPPGKTPSWLQPSPTGKDRKQGGRKPKPLWLSPEKPLAWKGRLPSDDVIGEGPGETEARDKGLRHEPGWGTSRSVNTKERPQRATTKVHSDDSDIFNQPPNRERPASGRRGSRKDAGSSSHGDDQPASREDTWSSRTPSRSRWRSEQEHTLHESWSSLSAFDRSHRGRISNTELPGDILDELLQQKSSRHSDLPPSKKGEQPGLSRGQDGYSGETDAGGDFKIPVLPYGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQISNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQDDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLAGAPEHFGDTILFTTDDDILEAIFYSDEMFDLDVGSLDSLQDEEAMRRPSTADGEGDERPFTQAGLGADERIPELELPSSSPVPQVTTPEPGIYHGICLQLNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGLDHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILFVDYLRAQLLPQPARRLDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEGVGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPYHTILFTEDRDIRHQEKHTTISNQAEDQDVQMMNENQIITNAKRKQSVVDPALRPKTCISEKETRRRRC
What is the function of this protein?
May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
What are the official names of this protein?
Katanin-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Note=When overexpressed, localizes to the cytoplasm where it associates with acetylated alpha-tubulin.
Protein: PER9_CYCRE
Sequence: AFEIINDIK
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 9.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: TRPA_PSEE4
Sequence: MSRLEQRFAELKAEGRSALVTFVTAGDPGYDASLEILKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALEAGQTLAKTLQMVREFRVGNQTTPIVLMGYYNPIHRFGVEQFVAEAKEAGVDGLIIVDLPPEHDAELATPAQAAGIDFIRLTTPTTDDARLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSALVDKIAQAKDAGQAVKDVLSLCSALADGVRAARV
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RS21_GLUOX
Sequence: MQVLVRDNNVDQALKALKKKMQREGVFREMKLRRHFEKPSEKRAREAAEAVRRARKMERKRLEREGF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.