PharMolix/UniProtQA huggingface dataset:
Protein: SF3B1_XENLA
Sequence: MAKVAKTHEDIEAQIREIQGKKAALDEEEGVGLDSTGYFDQEIYGGSDSRFTGYVTSIAANEQEDDDDDVSSATFEQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPQKIANREDEYKQQRRKMIISPERLDPFADGGKTPDPKLNARTFKDVMQEQYLTKEEREIRQQIAEKAKSGDLKVVNGSSASSAAQPPSKRKRRWDQTGDQTPGSTPKKLSSWDQAEVTPGHTPSSLRWDETPGRAKGNETPGATPGSKIWDPTPSHTPAGVATPGRGDTPGHVTPGHSGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGLTGFHMPTEDRSMKSVSDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMVQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDEKNTYIRYELDYTL
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex.  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.  May also be involved in the assembly of the 'E' complex.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
Splicing factor 3B subunit 1, 146 kDa nuclear protein, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155.
What is the protein family that this protein belongs to?
Belongs to the SF3B1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RTC5_PYRTT
Sequence: MGQGVSHDNPQLTLEQLSHTIAQRFAQKSFTPLELYCFNSVFRSFSDTESGVHYWSETTLCRFLELPDALGVGSVIFQMASYLGAFPLPSQAPAILTYEALLKVVTILTERYGAVLKKRGREIWLREIYRSLAIYDKGIRSSLEDKEKQKAKDKAAPMGSSSMGFAVDAPDDGEEGDEDEDDELVLAALDSMDAIDAFKHGEQSNVHHSIIPTDNFLKLVELLLLIAPIDAQQSLSTLAPELSDARVTELQRAANVILSSFGVEDHPGVTYRTFNTVISTCLPYLFNGLNPLFEHFLFAKDMDLSKRKGDPASPAKESTPVIPPPKVQSEPILREPGEILNLTILSQLSFFLKGSDLFRRLRPLYSGNTHGFSMGSFEKQVFNWRAPTILLVKGRLLPATPSTTRERALQDMLPPKRHPSSITPDSSNQTFIYGAYISSQWKNTGKSCFGDASTTLFQLSPTHDVFTASSFSHDYTYFSKSPTTPAGLGLGTPIPTQSASHSSSHFSQPVFRPGPVSLHLDDALEFAVFTHLAEGGGSFLPSKLPARKDKDWQDRFEIECLEVWGCGGDEVAEEQRKTWAWEEREAEARRRINLGTGDQELDRELLKMAGIISGDRSGGSMG
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_SALPK
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSEKTEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: CYSP4_VASCU
Sequence: YPESIDWRKKGAVTPVKNQGSCGSCWAFSTIVTVEGINKIRTG
What are the official names of this protein?
Cysteine proteinase 4, CC-IV, Cysteine proteinase IV.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: YL095_MIMIV
Sequence: MGGHVDVLDFLIMSGVGIEFTYAVTTASCYNKLSVIKYLHNQNYVINFTFALQEASCRGFVDIVEFLLTNCLDKIDTYHIKIILKSVILGRHNDIVKVYMDNGFYQE
What are the official names of this protein?
Uncharacterized protein L95.
Protein: FOG1_DANRE
Sequence: MSEMVHSRLKQGQGPAAAQQSFYPPGSPASVHKGATCFECDITFNNINNFYVHKRLYCSSRHQQGETGGLVKEGAVTAAAPPVSHAASPQARPVSRAASASPSCPDPAPGGTASEPKVVEVKIEDPGLKDATCSSSSEGEGPGGGQASEGSQSPSGSAEDQDDDPTRTFCQACNIRFSRHDNYIVHKRFYCASRHDPTNQRPHSGKAAFLPQPIRTRKRKKMYE
What is the function of this protein?
Transcription regulator that modulates expression mediated by transcription factors of the GATA family.  Cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family.  Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context (By similarity).
What are the official names of this protein?
Zinc finger protein ZFPM1, Friend of GATA protein 1, FOG-1, Friend of GATA 1, Zinc finger protein multitype 1.
What is the protein family that this protein belongs to?
Belongs to the FOG (Friend of GATA) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_PYRNV
Sequence: MARGPRYKVPFRRRREGLTNYRKRRRLILSRKPRLVVRKTNKHIIAQVVVAKPQGDVTIVGVDTRALAKFGWRGDENNTSAAYLLGLVAGYKARLRGVREAVLDIGLHRPVAGSRVFAVLKGALDAGLEIPHGEEVLPEDDRVSGKHVAEYAAKLKEENPELYKARFSRYLQRGVQPEDLPKHFEEVKKKIVEHYEAKLAKAVAQ
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SOX6_XENTR
Sequence: MSSKQAASPFTCKAEGEEEMTGDLASREMNECKDQIMASHLPLHPLNHNKPHSEELQSLVTTLPADLDWDSMISSQHRMDSESNKLRSLYSFRTSSTSPHKPDEGARERSDLMSSVNFGTPERRKGSLADVVDSLKQKKLEEMTRSEQEDSTCVEKILSKDWKDKMDRLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINILQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGLSYKPGDNYPMQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKIPTTPQPANAPGTLSPTGMKSEKRGTSPVAQIKDEAAQPLNLSARPKTADPIKSPTSPTQSFFPMSKTSPVSLSNKSGIPSPIRGPSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQLLTPHSIDGKLPINNMGLNNCRSDKMLLDAVTGKICIRSAHTERTHFENLGPQLTGKPNEDGKLGPGVIDLTRPEDVEGGATVVEARVYRDTRGRSSSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPISTPTGVVYPGTISMATTTPSPQMTSDCSSTSASPEPSIPVIQSTYGMKLDSGSLGGNDLMNGEDEMEMYDDFEDDPKSDYSSDNEANEAVSAN
What is the function of this protein?
Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation.  Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis.  Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate sox9's ability to transactivate.  Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes.  Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube.
What are the official names of this protein?
Transcription factor Sox-6.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCA_BLOPB
Sequence: MEKYLVGGAVRDALLKLPVQEKDWVVVGSSPQEMLNIGYEQVGKDFPVFLHPESHEEYALARTERKSGQGYTGFICHTAPSITIEEDLYRRDLTINAMAYDSHGNLIDPYHGQRDIKLRLLRHVSHTFHEDPLRVLRVARFAARFAHMNFAIAPETLILMKQMIHELLSLSPERIWTETKKALITDNPQVYFTVLRHCGALKILFPELDALFDIPTPTQYCTKINTGYYTMTTLSKAAYLTDDISVRFSVLCRDLGKGIPLNKINKNTKHHDHRKLGITLIHNLCNRFKIPHEIRNFSKITSEYHDYLYNVKILKPEMLMTLFHVFDCWRRPNRIDQIILVSQSDPIRWKNYNNYSLNQENLLRTAFTVTKKISTVDIIKDGFTGSNISRELYARRLHALNSWKNKQI
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.
Protein: SUC1_ARATH
Sequence: MGAYETEKPTKDAAALETQSPEDFDQPSPLRKIISVASIAAGVQFGWALQLSLLTPYVQLLGIPHKWSSLIWLCGPVSGMIVQPIVGFHSDRCRSKFGRRRPFIATGAALVAVAVFLIGYAADFGYKMGDKLEEKVKVRAIGIFALGFWILDVANNTLQGPCRAFLADLAAGDAKRTRVANAFFSFFMAVGNVLGYAAGSYTNLHKMFPFTMTKACDIYCANLKTCFFLSITLLLIVTVTSLWYVNDKQWSPPPRNADDDEKTSSVPLFGEIFGAFKVMKRPMWMLLIVTALNWIAWFPFLLFDTDWMGREVFGGDSDGNERSKKLYSLGVQSGAMGLMFNSIVLGFMSLGVEWIGRKLGGAKRLWGIVNFILAAGLAMTVLVTKFAEDHRKTAGDLAGPSASVKAGALSLFAVLGIPLAITFSTPFALASIFSSCSGAGQGLSLGVLNLAIVIPQMIVSLGGGPFDALFGGGNLPAFIVAAIAAAISGVLALTVLPSPPPDAPKATTMGGFH
What is the function of this protein?
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system).  This transport is both voltage- and energy-dependent.  Can also transport other glucosides such as maltose, alpha-phenylglucoside and beta-phenylglucoside.  May also transport biotin.  Required for normal pollen germination and anthocyanin accumulation induced by sucrose.
What are the official names of this protein?
Sucrose transport protein SUC1, AtSUC1, Sucrose permease 1, Sucrose-proton symporter 1.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACCA_CAUSK
Sequence: MAAHYLDFERPIADLESKIEELSKLSETAGPGAFESEIQALRDRAQQMRKEAYAGLDAWQKTMVARHPERPHLKDYIAGLIDEFVELRGDRKFADDQAIVGGLGRFRGVPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIARSTERGLVLGTPMVATIVGEGGSGGAIALAGANKVLILEHSIYSVISPEGAASILWRDGARAKDAAANMKITAQDLIQLKIVDRIVEEPAGGAHSDPDAAIQSVGDAVEDELKALMKLSAAELKKQRAARFYAIGREGLQ
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRIK4_PANTR
Sequence: MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
What is the function of this protein?
Receptor for glutamate.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity).
What are the official names of this protein?
Glutamate receptor ionotropic, kainate 4, GluK4.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi- pass membrane protein.
Protein: CIMA_GEOSL
Sequence: MSLVKLYDTTLRDGTQAEDISFLVEDKIRIAHKLDEIGIHYIEGGWPGSNPKDVAFFKDIKKEKLSQAKIAAFGSTRRAKVTPDKDHNLKTLIQAEPDVCTIFGKTWDFHVHEALRISLEENLELIFDSLEYLKANVPEVFYDAEHFFDGYKANPDYAIKTLKAAQDAKADCIVLCDTNGGTMPFELVEIIREVRKHITAPLGIHTHNDSECAVANSLHAVSEGIVQVQGTINGFGERCGNANLCSIIPALKLKMKRECIGDDQLRKLRDLSRFVYELANLSPNKHQAYVGNSAFAHKGGVHVSAIQRHPETYEHLRPELVGNMTRVLVSDLSGRSNILAKAEEFNIKMDSKDPVTLEILENIKEMENRGYQFEGAEASFELLMKRALGTHRKFFSVIGFRVIDEKRHEDQKPLSEATIMVKVGGKIEHTAAEGNGPVNALDNALRKALEKFYPRLKEVKLLDYKVRVLPAGQGTASSIRVLIESGDKESRWGTVGVSENIVDASYQALLDSVEYKLHKSEEIEGSKK
What is the function of this protein?
Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.  Makes part of the main pathway for isoleucine biosynthesis in G. sulfurreducens, i. e.  the citramalate-dependent pathway.
What are the official names of this protein?
(R)-citramalate synthase, Citramalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: HIS1_XYLF2
Sequence: MSASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIAQGVCDLGIVGRNELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEWEWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGSVEIAPRLGTADLICDLVSSGATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAFQEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_WOLWR
Sequence: MRWKDEGIIIAAKKYGDKNLILSLFTKNHGKRRGLTKLTNNSNYKFQISNLLHAEWSAKLPENLGFFKCELIESSFHHFFQDRLKSITIVSFSSILEKVLPESEPCAVLYDNFRYFIDVIKHNNQSWQSHYLNLELLLLTQLGFKLDLSKCAVTGVKENLQFISPKTGRAVSKKAGDYYADKLLPFPQMLHDVYNNNLQNSYSFQEFQLGLKVTGYFLNKYLFLQLNVKFPELRNLMLSL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: NUBP1_DROGR
Sequence: MQAPPPEHCPGVESEQAGRVSACAGCPNQSICSDPTKKLEDPGKALVAAAMKDVKHKLLILSGKGGVGKSTVTTLLTRYLARSCPDNNFGVLDIDICGPSQPRLLGALGENVHQSGSGWSPVGIDDNVCLMSIGFLLSSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVCTYLRDDSAPKDSLSAIIVTTPQEVALLDVRKEINFCRKQRIPILGVIENMSSFRCGHCGNSSDIFPAKTGGAAAMCAEMEVPLLGSLPLDPRVTRACDAGEDITAMKSETTDALAAICSKIMSSF
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35G5_PANTR
Sequence: MAGSHPYFNLPDSTHPSPPSAPPSLRWCQRCQPSDATNGLLVALLGGGLPAGFVGPLSRMAYQASNLPSLELLICRCLFHLPIALPLKLHGDPLLGPPDIRGRACFCALLNVLSIGCAYSAVQVVPAGNAATVRKGSSTVCSAILTLCLESQGLSGYDWCGLLGSILGLIIIVGPGLWTLQEGTMGVYTALGYVQAFLGGLALSLGLLVYRSLHFPSCLPTVAFLSGLVGLLGSVPGLFVLQTPVLPSDLLSWSCVGAVGILALVSFTCVGYAVTKAHPALVCAVLHSEVVVALILQYYVLHETVAPSDIMGAGIVLGSIAIITARNLSCERTGKVEE
What are the official names of this protein?
Solute carrier family 35 member G5, Acyl-malonyl-condensing enzyme 1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SLC35G solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HSCA_SHIF8
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQADIPDRSDNRVQRELLDATIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDNAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL20_FRATT
Sequence: MSRVKRGVTARARHKKVLNQAKGYYGARSRVYRVAKQAVIKAGQYAYRDRKVKKRTFRSLWIVRINAAARQHDISYSQLINGLNKVGVELDRKALAELAVYNKDAFAAVVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: TX264_HUMAN
Sequence: MSDLLLLGLIGGLTLLLLLTLLAFAGYSGLLAGVEVSAGSPPIRNVTVAYKFHMGLYGETGRLFTESCSISPKLRSIAVYYDNPHMVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGDTRSEHSYSESGASGSSFEELDLEGEGPLGESRLDPGTEPLGTTKWLWEPTAPEKGKE
What is the function of this protein?
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).  The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537).  Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).  Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270).
What are the official names of this protein?
Testis-expressed protein 264, Putative secreted protein Zsig11.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Nucleus. Chromosome. Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif (PubMed:31006537). Also found in the cytosol, nucleus and chromatin (PubMed:32152270). In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks (PubMed:32152270).
Protein: CD4_MACNE
Sequence: MNRGIPFRHLLLVLQLALLPAVTQGKKVVLGKKGDTVELTCNASQKKNTQFHWKNSDQIKILGIQGSFLTKGPSKLSDRADSRKSLWDQGCFSMIIKNLKIEDSNTYICEVENEKEEVELLVFGLTANSDTHLLEGQSLTLTLESPPGSSPSVKCRSPGGKNIQGGRTLSVPQLERQDSGTWTCTVSQDQKTVEFKIDIVVLAFQKASSTVYKKEGEQVEFSFPLAFTLEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALDAKTGKLHQEVNLVVMRATQFQENLTCEVWGPTSPKLTLSLKLENKGTTVSKQAKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVVPTWPTPVQPMALIVLGGVAGLLLFTGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHWFQKTCSPI
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Protein: DHSC_RICBR
Sequence: MTKTKQEIYNKRPTSPHLTIYKPQISSTLSILHRMTGVALFFAVSILAWWFILSKFDSNYIKLANCCCIIKICLILTSFAWFYHLCNGIRHLFWDIGLGFSIKAVNLTGWSVVICSVLFTILLWV
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b556 subunit, Cytochrome b-556.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.