PharMolix/UniProtQA huggingface dataset:
Protein: OST48_CANLF
Sequence: MRRRRKMEAGAAARAWSLLWLLLPLLGPVCASGPRTLVLLDNLNLRETHSLFFRSLKDRAFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISTFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDVSDLGQHTLIVADPENLLKAPTIVGRSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVVFSGSLDFFSDAFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIEQLSNGRWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLHSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSTVFLHMKEKEKSD
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity (PubMed:12887896).  Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, DDOST 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the DDOST 48 kDa subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: HISZ_SYNC1
Sequence: MNRKITVPEAMLPRGVKDFLPNKAAKLEYLKQSLKDVFHRWAFRPIMPPTLEYLDVLERGLGAGLRDKTFRFDDRQNGKLVAFCPDITPQVARIVATRMKGAPLPQRLCYNGKVLRHTEQQAGKDREIIQSGVELIGLQGPEADAEMIAMAIECLQSLGATEFTVDIGQVEFFHGVMDGLNLPAPQALAVQQAIARKDASGLSELLSELSLDDRKYAEVMALPRLFGGREVLDRAADIVVNDRSRRALENLRQILAVLEAYGVEEHVTFDLGELRGLGYHTGVTFQGFLSGMGTAVCSGGRYDTLTARYGMDAPATGFAFNLLNLLMALDRTLESAAVQPFDVMILQSGPDKRAAQSLARALRDQGYACARDIIERSLQDSLDYGRKMHFRHVMVVADQAGDVRLIRLADGSEQTISLQAVLAGEFRL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORGA_SALTS
Sequence: MIRRNRQMNRQPLPIIWQRIIFDPLSYIHPQRLQIAPEMIVRPAARAAANELILAAWRLKNGEKECIQNSLTQLWLRQWRRLPQVAYLLGCHKLRADLARQGALLGLPDWAQAFLAMHQGTSLSVCNKAPNHRFLLSVGYAQLNALNEFLPESLAQRFPLLFPPFIEEALKQDAVEMSILLLALQYAQKYPNTVPAFAC
What is the function of this protein?
Oxygen-regulated protein required for bacterial internalization.
What are the official names of this protein?
Oxygen-regulated invasion protein OrgA.
Protein: CH10_PAEAT
Sequence: MSVSIKPLEDRIVVRPLEAEQTTASGLVIPDSAQEKPQEGEVVAIGPGRFDDNGNRVPVDVAVGDVVIYSKYGGTEVKTGGNEYLVLSARDVLAIVVK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHI_PIPCE
Sequence: MFPMITGFMNYGQQTVRAARYIGQSFAITLSHTNRLPVTIQYPYEKSITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPISVIEDYTIQTNNYELNSYKKMTDKPLDSEKITN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PREP_MOUSE
Sequence: MWRFSGRRGLCAVQRLSCGRVHHRVWREKSDQACERALQYKVGEKIHGFTVNQVTPVPELFLTAVKLSHDNTGARYLHLAREDKNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAMTASDYTIYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPRDPQTPLIFKGVVFNEMKGAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFQLEGHLKQIHEEALSKFQRLEQSTAVPAQPHWDKPREFHITCGPDSLATETAKQTTVSVSFLLPDITDTFEAFTLSLLSSLLIAGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDVKTVRELVDRTIEEVIEKGFEDDRIEALLHKIEIQTKHQSASFGLTLTSYIASCWNHDGDPVELLQIGSQLTRFRKCLKENPKFLQEKVEQYFKNNQHKLTLSMKPDDKYYEKQTQMETEKLEQKVNSLSPADKQQIYEKGLELQTQQSKHQDASCLPALKVSDIEPSMPFTKLDIGLAAGDIPVQYCPQPTNGMVYFRAFSSLNTLPEDLRPIVPLFCSVLTKLGCGILNYREQAQQIELKTGGMSVTPHVLPDDSQLDTYEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVKMTAQELSNGISDSGHLYAALRASKTLTPSGDLQETFSGMDQVKVMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMPQAEKEVENFLRNVGRSKKERKPVRPHIVEKPTPSGPSGAAHVSGSQIVRKLVTDPTFKPCQMKTHFVLPFPVNYIGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLTHSGIFTLYSYRDPNSIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDSPVAPSDKGMDHFLYGLSDEMKQAYREQLFAVNHDKLTSVSHKYLGIGKSTHGLAILGPENSKIAKDPSWIIK
What is the function of this protein?
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing.  Has an ATP-independent activity.  Specifically cleaves peptides in the range of 5 to 65 residues.  Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.  Degrades the transit peptides of mitochondrial proteins after their cleavage.  Also degrades other unstructured peptides.  It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion.  It is a highly efficient protease, at least toward amyloid-beta protein 40.  Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.  It is also able to degrade amyloid-beta protein 42.
What are the official names of this protein?
Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PPK1_BRASO
Sequence: MDTEQVTELAAKEPVAAPTNEIASSPERFINRELSWLHFNRRVLEESVNPRHPALERVRFLSISANNLDEFFMVRVAGIRAQVREGIAERSPDGLTPTEQLKLINETVSQLAIDQQAIWRDLRKFLAELGIVLVDGQDVTKAERAWIEDHFLANIFPLLTPLAIDPAHPFPFIPSLGFTVALQLTRTSDGRPMNALIRMPGKIDRFIRFPGAKDGVIRLITLEQATSLFIGRLFPGYTVKGQGAFRIIRDSEIEIEEEAEDLVRLFETALKRRRRGSVIRLEIEAAMPEELRQFVQDALATTDDEVFVVDGVLAMNELSQLTRVDRPDLEFAPYVPRHPERVRDHGGDIFAAIRQKDLIVHHPYESFDVVVQFLQQAARDPDVVAIKQTLYRTSNNSPIVRTLVEAAEAGKSVTALVELKARFDEEANIRWARDLERAGVQVVYGFLQLKTHAKLSMVVRREGGSLTTYVHTGTGNYHPVTARIYTDLSYFTSDPVIGRDVTRVFNYITGYAEPIDIEKMAVSPLTLRKRMIEHIHGETSFARQGKPAVIWMKMNSLVDPDIIDALYEASQAGVSIELIVRGICCLRPGIPGLSDNIRVKSVIGRFLEHGRIYCFGMGQGLPSAKAAVYISSADMMPRNLDRRVEVLCPLQNPTVHQQVLEQIMVANLKDTEQSWQLLPDGSSTRMKAAKGEEPFNLHNYFMTNPSLSGRGKSLKESSPRRLTRRNERPPS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: KTHY_THEVO
Sequence: MFIAVEGIDGAGKTTLAKSLSSLLEKEGFRVFLTREPTDDIRNYEGDDVELFIKFTLDRYKHQKEIRKKLNEGFVVISDRYIRSSYAYEMKGAAAALGSEEKAKEWMDCVSNIITIRPDINILVQVDVQVGLDRISKRNGTITHFEQRERLNEALKIYNSFDWDIKVDGTDPLDKITNEVYLYLKNKIGL
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: NTPP_ANAPZ
Sequence: MDSLVLASSSEYRLRLLKQLMIVPGEVISPDLDESVHKGELPRLYAERVAREKALKVFSSRPDKFVLGADTVAYCGRRIMLKTDDEAQATEYLEMISGRRHRVCTAVCLCAPTGDVRVRSVVSVVKFKRLSKDEIDCYIRSGEWKGKAGGYSIQGWASALISWMQGSHSSIVGLPLHETYCLLSGYFKLTHIP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNNM5_CAEEL
Sequence: MSLFLFAIFQLALGSPGAPNGPNVPLQLTGVRRGLDHVQKLPSEAFSFKLFGKNLAEDGYYFTTATRCEDSHLSTVSTVRATVKESYCSYAILSVPEGLPFNVSTSVYHLCHKNATIYTQKFLVVHEKKAAAAKYMGDEIVFCFFCILMSAYASGMTLGYMKFSMIDLNTMLKIAEGDAAKKRVRRIMHFRRRSTQLVVTFSLFSSVFTVLFTTTCEKMLHGVSNEDVLKMAVPALICLIFAEMIPQAVCNSKFGFNLAASLWFVTVIIFFVTLPIAYPASLVLGRFLKRDVREVMTPEEKTCLLRSMAQNEREKTILENATTFTLKKVGQLMVPIEEVFMLSRSQKLNRSTVLTLVEKGYTRIPVYDNKNRSVIVGMLNMKNFNLLMVKTNLIDEPTVKEALHALELLKDRTVKFAVKYVNIEMNAHLLLNRMKTGDFHFACVVEYSAYDSKVVGIITIEDILEKLIGKIDEINELRVRSSIDDRGDNAVIGWCREAGSDKKYPLPFSQQLRILQHLLSECQVLKSLDIGIMKAKQILSLDRIRVGKKNDKLELHDLLLVIFEGTVLVTNEVETFERVIDVPSQRSSSTVNSQQHRQQTTDNSRSTPVPVLIIGKPLLNRLMKSLGSPFSEPLGPKDNVSELVVVSEEASYFKLRLEDLMNSINGCRKVDRNGHTTTGESLLQTLNSRASTSTSTTPACRTPLSVDARSQDETTPFMEKQE
What is the function of this protein?
Probable metal transporter.  Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-4 to regulate Mg(2+) homeostasis.
What are the official names of this protein?
Metal transporter cnnm-5, CNNM family homolog 5.
What is the protein family that this protein belongs to?
Belongs to the ACDP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YDIB_ECO27
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPAAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SSL2_ARATH
Sequence: MMKLLLVVATSVALIFSVTDLSGEGPKHGGESMLTVQIPDFRLIPTTGALGPESFVFDFFGDGPYTGLSDGRIVKWLANESRWIDFAVTTSAREGCEGPHEHQRTEHVCGRPLGLAFDKSTGDLYIADAYMGLLKVGPTGGVATQVLPRELNEALRFTNSLDINPRTGVVYFTDSSSVYQRRNYIGAMMSGDKTGRLMKYDNTKQVTTLLSNLAFVNGVALSQNGDYLLVVETAMCRILRYWLNETSVKSQSHDNYEIFAEGLPGFPDNIKRSPRGGFWVGLNTKHSKLTKFAMSNAWLGRAALGLPVDWMKVHSVWARYNGNGMAVRLSEDSGVILEVFEGKNENKWISISEVEEKDGTLWVGSVNTPFAGMYKI
What are the official names of this protein?
Protein STRICTOSIDINE SYNTHASE-LIKE 2, AtSSL2, Strictosidine synthase, Strictosidine synthase 10, AtSS10.
What is the protein family that this protein belongs to?
Belongs to the strictosidine synthase family.
What are the subcellular locations of this protein?
Vacuole.
Protein: RL11_XANAC
Sequence: MAKKITAFIKLQVKAGQANPAPPVGPALGQRGLNIMEFCKAFNAATSKLEPGLPTPVIITAYSDRTFTFVTKSTPASVLLKKAAGVSSGSKRPNTDKVGKVTRKQLEEIAKVKEADLTAAELEAAVRTIAGSARSMGLTVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: UPPP_SALPC
Sequence: MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQREGESKGRLTLIHILLGMIPAVVLGLVFHDTIKSLFNPINVMYTLVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATVLDLYKSWSFLTAADIPMFAVGFVTAFVVALIAIKTFLQLIKRISFIPFAIYRFVVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_MARMM
Sequence: MSKVIGIDLGTTNSCVAVMESGQPKVIENSEGVRTTPSVVAFTEDGERLIGQPAKRQAVTNPDYTFFAIKRLIGRMMDDPTVKKDIDMVPYKIVPSDSNDAWVQGRDKKYSPSEISAFTLQKMKETAESYLGEKVEKAVITVPAYFDDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKGENKTIAVFDLGGGTFDVSVLEIGDGVFEVKATNGDTFLGGEDFDMRIVQYLADEFKKENGIDLKSDKLALQRLKEEAEKAKKELSSATSYEVNLPFITADASGPKHLNIKLSRAKLEALVEDLVKRTLEPCKKALKDAGLSPSDIDDIVLVGGMTRMPKVQEAVKGFFGKDPHKGVNPDEVVAMGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQTFSTADDNQTAVTIRVSQGEREMAADNKLLGQFDLVGIPPSPRGLPQIEVTFDIDANGIVNVSAKDKATGKEQQIRIQASGGLSDDDIEQMVKDAEANADADKKKKELVEAHNGAEAMIHQTEKQLEEFGDKVPGEDKDAIDAALTELKEVKDGEDLEAIQQKTQALVQAAMKLGEAMYAAQQTEAAEADAKSDAEGDEDVVDAEFSEVDDDKKKDA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL19_ECOLU
Sequence: MSNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLRERTGKAARIKERLN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: CRVP_NAJMO
Sequence: NVDFNSESTRRKKKQNEIVDLHNSLRRTVN
What is the function of this protein?
Inhibits calcium-activated potassium channels (KCa), voltage-gated potassium channel (Kv), and the calcium release channel/ryanodine receptor (RyR).
What are the official names of this protein?
Cysteine-rich venom protein mossambin, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3907_BACCZ
Sequence: MINFNFFMNDVVRQAREEIVSAGYTELTTPEAVDEAFKRNGTTLVMVNSVCGCAGGIARPAAAHSVHYDKRPNHLVTVFAGQDKEATARAREYFEGYPPSSPSFALLKDGKIVTMVERHEIEGHEPMQVIAKLQSYFEENCEEL
What are the official names of this protein?
UPF0403 protein BCE33L3907.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: DAPA_BIFA0
Sequence: MSDGIMHLLDPAPFGRVLPAMITPMKPNGDVDFDMAQTVAKQLVADGADGLVVNGTTGESPTTHMDEKVELVKAVKEVVDVPVISGAGSNDTAHTVRMVEQTQEAGADAVLVVCPYYSRPSQQGIFCHYQAVNESADKPIIVYDVPGRTGVRIALDTYVHLAELDHVKAVKDATGDIAGAVRKRMETGLTWYSGDDALYLPFLSIGAVGIISVVAHAAAKPMRELAEAFDRGDIAKAQGLANRIAPVIEAMNGTGFQAVMAKAALKVRGIMECTTMRLPNIGPNDEQIEVVRDGLRASGLIPE
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSTOS_DANRE
Sequence: MSESSSEDENTARLKEAVWSFKPEDVKINGKENNGRQSHRADVSKHEHDGNELGTTPEFRSHVAKKLGTYLDGCISEVCSDTVEPAQSENREDEEGFRLFSSSTPGKWMEQSPPPPPKRRPVPSSSDSDSEMEMRFREAAVSLSDILGPVAQNLSEKTEEKSTKEETEDTVTKMKKKKKRKTSSEESQDKVNHQTEKQSNVEGNQEQTTAGERLKKKKKKKKKKRKKLEKDIKKDE
What is the function of this protein?
Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo.  Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis.
What are the official names of this protein?
Protein CUSTOS.
What is the protein family that this protein belongs to?
Belongs to the CUSTOS family.
What are the subcellular locations of this protein?
Nucleus envelope.
Protein: HPTR_HUMAN
Sequence: MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
What is the function of this protein?
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL).  This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes.  Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
What are the official names of this protein?
Haptoglobin-related protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL).
Protein: FLPA_METAC
Sequence: MPDIKLLSEGIFEIMKDKRQLATLNLDPGKVVYGEKLISVEGAEYRTWDPRRSKLGAMVLKKFNIPLSKDSKVLYLGAASGTTVSHVSDIASEGAVYSVEFASRSMRDFIRLASRRKNIFPILADAGKPDSYAHIVEPVDLIFQDVAQPNQAEIAARNAARFLNKNGYLLLSIKARSIDTAASPKEIFKEEVKKLEQAFEPGFEILTARDLMPYHEDHLGVLAKLKE
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: EDF1_MOUSE
Sequence: MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQRGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPKAK
What is the function of this protein?
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities.  Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1.  Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm.  Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity).
What are the official names of this protein?
Endothelial differentiation-related factor 1, EDF-1, Multiprotein-bridging factor 1, MBF1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Protein: RS8_STRPB
Sequence: MVMTDPIADFLTRIRNANQVKHEVLEVPASNIKKGIAEILKREGFVKNVEVIEDDKQGIIRVFLKYGKNGERVITNLKRISKPGLRVYAKRDDMPKVLNGLGIAIISTSEGLLTDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y243_RUMCH
Sequence: MARGGFPGGGFGGNMNNLMKQAQKMQKDMEKAQQDLENKTIEVSVGGGAINIVATGKKEIKEITIKPEVVDPDDVEMLQDLILSAVNEALRKADELANSEMSKITGGLGGLPGMF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Ccel_0243.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CD302_HUMAN
Sequence: MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD
What is the function of this protein?
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
What are the official names of this protein?
CD302 antigen, C-type lectin BIMLEC, C-type lectin domain family 13 member A, DEC205-associated C-type lectin 1, Type I transmembrane C-type lectin receptor DCL-1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Protein: RR14_ZYGCR
Sequence: MAKKSSIEREKKRSELTQKYSNLRKSLKEMIHQASSLEEKWSIQRQLQRLPRNSAATRVHRRCFVTGRPRAVYRDFGLSRHVIREMAHACLLPGVIKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CEMA_ILLOL
Sequence: MPKRKALTPFPYLASIVFLPWGISLSFNKSLESWVINWWNTRQSETFLNDIQEKKVLERFIELEELFLLDEMIKEYSGTHIQKLRIGIYKETIQLVRMHNQDHIHLILHFSTNIICFTILSAYSILGNEELVILNSWVQEFLYNLSDTIKAFSILLLTDLCIGFHSPHGWELMIGLVYQNFGFAHNEQVISGLVSTFPVIIDTILKYWIFLFLNRVSPSLVVIYHSMNE
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.