PharMolix/UniProtQA huggingface dataset:
Protein: NUOD_LEPIC
Sequence: MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELSRIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLEKDIYPDFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGVDWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHADLPHAYLPEKHKVYNNMEELIYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSBN_CITSI
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HBL2_BRANA
Sequence: MGEIVFTEKQEALVKESWEILKQDIPKYSLHFFSQILEIAPAAKDMFSFLRDTDEVPHNNPKLKAHAVKVFKMTCETAIQLREKGKVVVADTTLQYLGSVHFKSGVLDPHFEVVKEALVRTLKEGLGEKYNEEVEGAWSKAYDHLALAIKAEMKQEDSQKP
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin 2, BRAna GLB2, Hb2.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: PPAT_STAAR
Sequence: MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDLKSAAKAAIDTHGVGAGAVRTINGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISAVMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDLRAKAKEAVESGQYNKVMYITDGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMASTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGEEKTTQEFSKRLKDEGVYVKSIVFPTVPRGTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMNLI
What are the official names of this protein?
Putative pyridoxal phosphate-dependent acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: SRGP2_HUMAN
Sequence: MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV
What is the function of this protein?
Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212).  Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832).  SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity).  Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832).  Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity).  In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482).
What are the official names of this protein?
SLIT-ROBO Rho GTPase-activating protein 2, srGAP2, Formin-binding protein 2, Rho GTPase-activating protein 34.
What are the subcellular locations of this protein?
Cell membrane. Cell projection, dendritic spine. Postsynaptic density. Postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome. Nucleus. Cytoplasm, cytosol. Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity).
Protein: DCUP_LISMF
Sequence: MTKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTPLPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEVPYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSKNYHQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGASAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTPIIMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLKEANRILQEGVLEPGYIFNLGHGVFPEVPPEMLKKLTNYIHERSEILLKKDDIK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS213_FRATT
Sequence: MPSVRIKEREPFDVALRRFKRSCEKAGIVSELRRREYFEKPTWARKRKKTAAVKRAHKSNIIVKR
What are the official names of this protein?
30S ribosomal protein S21 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: COX1_THETH
Sequence: IRALPWDNPAFVAPVLGLLGFIPGGAGGIVNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNLTGKPISDAQRRLGLAVVWLWFLGMMIMAVGLHWAG
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c ba(3) subunit I, Cytochrome c oxidase polypeptide I, Cytochrome cba3 subunit 1.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 1433X_MAIZE
Sequence: ILNSPDRACNLAKQAFDEAISELDSLGEESYKDSTLIMQLLXDNLTLWTSDTNEDGGDEIK
What are the official names of this protein?
14-3-3-like protein.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: DPP5_TRIVH
Sequence: MAAAKWLIASLAFASSGLAFTPEDFISAPRRGEAIPDPKGELAVFHVSKYNFDKKDRPSGWNLLNLKNGDISVLTTDSDVSEITWLGDGTKVVYVNGTDSVKGGVGIWISDAKNFGNAYKAGSVNGAFSGLKLAKSGDKINFVGYGQSTTKGDLYNEAAAKEAVSSARIYDSLFVRHWDTYVGTQFNAVFSGALTKNGDKYSFDGKLKNLVQPVKYAESPYPPFGGSGDYDLSSDGKTVAFMSKAPELPKANLTTSYIFLVPHDGSRVAEPINKRNGPRTPQGIEGASSSPVFSPDGKRIAYLQMATKNYESDRRVIHIAEVGSNKPVQRIASNWDRSPEAVKWSSDGRTLYVTAEDHATGKLFTLPADARDNHKPEVVKHDGSVSSFYFVGSSKSVLISGNSLWSNALFQVATPGRPNRKLFYANEHDPELKGLGPNDIEPLWVDGARTKIHSWIVKPTGFDKNKVYPLAFLIHGGPQGSWGDSWSTRWNPRVWADQGYVVVAPNPTGSTGFGQKLTDDITNDWGGAPYKDLVKIWEHVHNNIKYIDTDNGIAAGASFGGFMVNWIQGQDLGRKFKALVSHDGTFVGSSKIGTDELFFIEHDFNGTFFEARQNYDRWDCSKPELVAKWSTPQLVVHNDFDFRLSVAEGVGLFNVLQEKGVPSRFLNFPDETHWVTKPENSLVWHQQVLGWVNKWSGINKSNPKSIKLSDCPIEVVDHEAHSYFDY
What is the function of this protein?
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini.  Contributes to pathogenicity (By similarity).
What are the official names of this protein?
Probable dipeptidyl-peptidase 5, Dipeptidyl-peptidase V, DPP V, DppV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Secreted.
Protein: TR164_ARATH
Sequence: MARLVFSLNLPSSHGFNLSPRNLQSFFVTQTGAPRFRAVRCKPNPESSETKQEKLVIDNGETSSASKEVESSSSVADSSSSSSSGFPESPNKDINRRVAAVTVIAALSLFVSTRLDFGISLKDLTASALPYEEALSNGKPTVVEFYADWCEVCRELAPDVYKIEQQYKDKVNFVMLNVDNTKWEQELDEFGVEGIPHFAFLDREGNEEGNVVGRLPRQYLVENVNALAAGKQSIPYARAVGQYSSSESRKVHQVTDPLSHG
What is the function of this protein?
Thiol-disulfide oxidoreductase that participates in various redox reactions in the chloroplast.  Mediates the reduction of PSI-N in the thylakoid lumen.  May interact and probably reduce other target proteins of the thylakoid membrane, such as FTSH2, FTSH8, LHCB5, atpA, atpB, atpE, petA and petC.  Involved in the biogenesis of the plastid cytochrome b6f complex.  Reducing equivalents are provided by stromal M-type thioredoxins and probably transduced through the thylakoid membrane by CCDA.  Possesses low insulin disulfide bonds reducing activity.
What are the official names of this protein?
Thioredoxin-like protein HCF164, chloroplastic, Protein HIGH CHLOROPHYLL FLUORESCENCE 164.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: COA4_TTV1K
Sequence: MPSFSTQSITRPSVGVAIGPDGIYRALYGWYGNEQPLEIDKCSYDLSTCSPVVSSGPTIGDGYGGFYDGTNIWFSGSDEANDQGVVASYNPSTGAFNYAYYPGNSTKYVIKIFYYNGYYYLITCCDPGTLLKCTNPLNPSTCTQLNINAPTSFTVQEYYMYTQGSYALLSYFQKNMNNKLFSLCNFDGTNLYNCINIYSTTGILHYLHHSLLEEQYVEII
What are the official names of this protein?
Coat protein TP4.
What are the subcellular locations of this protein?
Virion.
Protein: CLGN_CANLF
Sequence: MSSPWSTVISMHFQSFWLCLGLLFISVNAEFMDDDVEMEDFDENSEEIDVNEGELPSEINYKTPQPMGEVYFTETFDSGRLAGWVLSKAKKDDTDAEISIYDGRWEIEELKENRVPGDRGLVLKSRAKHHAIAAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDGLNLENFYDKTSYTIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLIDQVVVNQGSLLEDVVPPINPPKEIEDPSDKKPDEWDERAKIPDPSAVKPEDWDESEPAQIEDLSVVKPDGWLDDEPKFIPDPNAEKPDDWNEDMDGEWEAPRISNPACRIGCGEWSPPMIDNPKYKGVWRPPMIDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFRALGLELWSMTSNIYFDNFIICSEKETADRWAADGWGVKILVANANEPGIFKQLMAAAEERPWLWLIYFVTAGLPIALIASFCWPRKVKKKYEDSEYKKTDICKPQTKGALEQEVKEKKAALEKPVDLEEEKKQSDGETVEKEEEAEPEEKSEEEIEIIEGQEEGNKSNKSGSEDEMKEADESTGSGDGPVKSVRKRRVRKE
What is the function of this protein?
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida.  Required for normal sperm migration from the uterus into the oviduct.  Required for normal male fertility.  Binds calcium ions (By similarity).
What are the official names of this protein?
Calmegin.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: SYS_SYNJB
Sequence: MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGEIIRQGADPQGPEVAALRQRGVDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGRDEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAVKVAQSRFVAMVGAGAALERALIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLTNLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEAEHEKLVQDAEAILQMLELPYRVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCWDFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALLENHQQPDGSIRIPKALRPFLSSRFLSEDGILIPAA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REP_BPPHM
Sequence: MHCIRPIKAGFNATGDIVYSSKKISKELASFAFPCRKCIPCRLNMAREKAIRAYHESQMWDDNIFLTLTYDDEHLKSDRLQWIDFDLFIKRLNEKLNRGLSKENRRPLPYMVTGEYGDKTKRPHWHVLIFNFRPDDAKKHYVTELGEQVYTSEFIRDLWTHGNIEFGSVTLDSASYVARYAAKKLAHGNDQDHDYHPIHNTSKKHAIGKKWIEKYHEQTFSRGYVVLPNGSQGPIPRYYQDWYKKNHPEKWMEYDAKVKLKSKELAEMQSRKDQLDDFANFINYRGGTNYPLSRTQVKLAILKSKFKQLQEKLKL
What is the function of this protein?
Plays an essential role in viral DNA replication.  Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII).  In turn, viral DNA replication initiates at the 3'-OH of the cleavage site.  After one round of rolling circle synthesis, protein VP4 is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion.
What are the official names of this protein?
Replication-associated protein VP4, Rep, VP4.
What is the protein family that this protein belongs to?
Belongs to the microviridae Rep protein family.
Protein: DNAA_HELMI
Sequence: MTSQFASLWQQSLEILKQELKPASFDTWLKNTQLVTIQNGEAHIGVPNDLARDWLENRYATLVKNALSVVLGESVEVRFFTPSADSRRSEPSRRPVATEESSPPLLNPKYTFDTFVVGNSNRFAHAAALAVAEAPAKAYNPLFVYGGVGLGKTHLMQAIGHFVIEQHPQSRVVYVSSEKFTNELINAIRDDKTVEFRNRYRNIDVLLIDDIQFLAGKERTQEEFFHTFNALHESSKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDINPPDLETRIAILRKKAILENLDVPNEVMVFIANIIQSNIRELEGALNRVIAYANLSGKSLTSEVAEEALKNIIPSHRAKVITIALIQEIVAEHYNMRVEDFKAKKRTRDVAFPRQIAMYLSREMLDVSLPKIGEEFGGRDHTTVIHAHEKITKDIEKDPQLEMTIQVLKEKIQRA
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_MESFL
Sequence: MLRKYEAMFILDQDTQDVNALSSRMIEIISKDGKVIEKNDLGLIEFAYKINHKKKGHYFVVIVEATAEAIKEFERIANIEKNVVRTLIINTENEQGYEQSVQLSKTDMTKFEEERKAKRDFKKPFVKKEFNKPTEKRTFEKPAEVTVEVKEVVVEEVKQTVKPAKKVAEAKVEEVSHEEAHDFVSKMEAKYKAHLAETVEEHVEEVEVEEAKTTAKKPAAPKMSAAERAKVDGSHNIDEERYELQKYSNKLRSVAIEKNLPKKLQEVNLRDLTKKELIEYMRKVRAALAK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RPOZ_BIFLO
Sequence: MAFGTDPTPDGLANPPIDDLMKHADSKYALAIFAAKRARQINSYFTQLNEGLLQNIGPLVEYQNNEKPLSIAFREIDEGLLEETLGEDDANEGN
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RCC1L_MOUSE
Sequence: MLAAARALRGPRPRWPTPAREHWTPAGRSRSRREAAEAEADVPVFQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1.  Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876).  Plays an essential role in mitochondrial ribosome biogenesis.  As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (By similarity).
What are the official names of this protein?
RCC1-like G exchanging factor-like protein, RCC1-like, Williams-Beuren syndrome chromosomal region 16 protein homolog.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: PCABP_PSEAE
Sequence: MMKKLLLVATLMAGAAQATAAEKLYLFNWNDYIAEDTLKRFEQQCGCELVQEFYSGTEEMMAKLAAGASGYDVIIPTQNAVEALIRKGDLLELDKSRLANLSNEAAGYLDKDFDKGNRYSLPYAFTTTLVGYNKTELDKLGIDPADWSVIFDPAVLEKIKGRVTVMDDPQELFGAALKYLGHSANDTDPQHWKEAQALILAAKPYWAAFNSSSYIKELTLGNIWVAHGYSSDMYQARADAEAAGRAFKVDFALPRQGAVLAIDNMVIHKGSKNPDLAYRFIDFMLDGRNASELTNQIGTGTPNAAALPFIKPEIKTLAALFPDATTQARLEPLKDLNSRQRRALNKLWTEIKLR
What is the function of this protein?
Binds putrescine and cadaverine.
What are the official names of this protein?
Putrescine/cadaverine-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: IRX5_XENLA
Sequence: MSYPQGYLYQPSASLALYSCPAYSTTVISGPRTDELGRSPSGSAFSPYAGSTAFTASSAGFSSPLQYSGDPAAAFTSYVGSPYDHSAGMAGSLEYHPYAAPLGIYAYGDPAYRKNASRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEDDDENIDLEKNEEDDPSKLEENGNQDGDAGDQKRSPDGVDFVRLEGEVHLGKELDQTRNNSELNELDERNGHLSNSSSPPTPPLCPPDQSPQAQEDQNLHGHTHQSIQQLLHHSNQPHPLDLVNRNTSVQHGPVTNNATSVIHSPPASTSKPKLWSLAEIATSSDKVKERSNAAEVAGTTAAKSMVVSASSPSRSPSAQCHFPNNTVLSRPLYYSIPFYPGYTNYGTFSHLHSHHGPSSSVNSTYHFNGINQPVLNKAEGLAKECKHISQSQDDLNKGTPYEMKKGMSSI
What is the function of this protein?
Acts partially redundantly with other irx members in neural patterning.  Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord.  Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes.  Does not appear to play a role in pronephros kidney development.  Involved in craniofacial and gonadal development.  Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
What are the official names of this protein?
Iroquois-class homeodomain protein irx-5, Iroquois homeobox protein 5.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OAT_ARATH
Sequence: MAATTRRLLYYVSKRFSTAGVRRSYGGLPQSNSKSPPSSSQRLMELESEFSAHNYHPVPVVFSRANGSTIWDPEGKRYIDFLAAYSAVNQGHCHPKIMKALQEQVEKLTLSSRAFYNDKFPVFAERLTNMFGYDMVLPMNTGAEGVETALKLARKWGHEKKNIPKDEAIIVSCCGCFHGRTLAIVSMSCDNDATRGFGPLLPGNLKVDFGDADSLEKIFKEKGDRIAGFLFEPIQGEAGVIIPPDGYLKAVRELCTKYNVLMIADEVQSGLARSGKMLACDWEEIRPDMVILGKALGGGVIPVSAVLADKDVMLHIKPGQHGSTFGGNPLASAVAMASLDVIVEEKLVERSASLGEELRIQLNEIKKQFPKYIKEVRGRGLFNAIEFNSESLSPVSAYDICLSLKERGVLAKPTHNTIVRLTPPLSISSDELRDGSEALHDVLELDLPNLLKINSGKTPVSHITECDRCGRNLYA
What is the function of this protein?
Mediates degradation of arginine for nitrogen recycling.  Plays a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response.
What are the official names of this protein?
Ornithine aminotransferase, mitochondrial, Ornithine delta-aminotransferase, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VPX_HV2BE
Sequence: MTDPRERVPPGNSGEETIGEAFEWLERTIEALNREAVNHLPRELIFQVWQRSWRYWHDEQGMSASYTKYRYLCLMQKAIFTHFKRGCTCWGEDMGREGLEDQGPPPPPPPGLV
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells (PubMed:19264781, PubMed:21613998, PubMed:21720370, PubMed:22973040).  Targets specific host proteins for degradation by the 26S proteasome (PubMed:19264781, PubMed:21613998, PubMed:21720370, PubMed:22973040).  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1 (PubMed:19264781, PubMed:21613998, PubMed:21720370, PubMed:22973040).  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1 (PubMed:19264781, PubMed:21613998, PubMed:21720370, PubMed:22973040).  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (PubMed:19264781, PubMed:21613998, PubMed:21720370, PubMed:22973040).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: METK_ACICJ
Sequence: MRDKGDYLFTSESVSEGHPDKVADRISDTVLDAFLAADPYARVACETLVTTNRIVLAGETRGPSTITREYLAHLARLAVHDIGYEQEGFSWRDAKIDVLLHEQSVDIAVGVDAAGNKDEGAGDQGIMFGYACSETDALMPAPIYYAHLILRRMTELRKIGDARAAGLLPDAKSQVTLRYADGKPVGTTSIVVSTQHEDGMSQDEIKAMLRPLVTELLPDGWMCPDDQFYVNPTGKFVIGGPDGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYMCRYLAKNVVAAGLATRCTIQVSYAIGVSHPLSVYVDMHGTERDVDHARLETVLRELVNLTPRGIREHLHLNRPIYVPTSAYGHFGREPDDRLGTFTWEKTDLAPALKAAFGR
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOH_LEGPL
Sequence: MNIHLDKHGQGMPLVLFHGWGFDSQIWQPIIPYLKPKYQIILVDLPGFGLTPMMDWESFKKNLFDQLPDKFALAGWSMGGLYATRLAIEEPARVQYLINITSSPRFISDIDWPGVAEEVFVNFYNNLSKDINKTLKEFISLQLNKMKFDFKIGNPPSPEGLAFGLEILGTWDFREQLKQISIPTVYLFGRLDPITPAKTMAIMEKNYPNFKYVLFNRAAHMPFLSHTDLFITMMDEFIK
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.