PharMolix/UniProtQA huggingface dataset:
Protein: CCM2_HUMAN
Sequence: MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
What is the function of this protein?
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity.  May act through the stabilization of endothelial cell junctions (By similarity).  May function as a scaffold protein for MAP2K3-MAP3K3 signaling.  Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
What are the official names of this protein?
Cerebral cavernous malformations 2 protein, Malcavernin.
What is the protein family that this protein belongs to?
Belongs to the CCM2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAND_EMENI
Sequence: MKHLLSLVCTLGAATLAASAAAEAGSMPSANGLDFVIDGEASYFAGSNAYWLSFLTNNADVDLALDHFAESGLKILRIWGFSDVTAEPSDNKVYFQLHQNGSSTVNTGPNGLERLDYIISGAEKRGIKLVIPLVNYWDDFGGMNAYISAYGGDKPGWYTNDKIQAAYHAYVKAVVSRYVDSPAIFAWELANEPRCSGCDTSIINQWATKTSSFIKSLDPNHMVAMGDEGMGLPGDSNYPYSYYEGNDFALNLAIPDIDFGTLHLYTTDWGVSNNSWGNKWVQDHAAVCKSAGKPCLFEEYGMKGNHCTYELAWQKTALATPGMAADLFWQFGENLSSGQTHNDKYTVYYGSNEWKCVVSDHVAAVAVRRYRLPVGGGQHGP
What is the function of this protein?
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase D, Endo-beta-1,4-mannanase D.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: REV_SIVS4
Sequence: MSSTEEELRRRLRLIHFLHQTTDPYPQGPGTANQRRRRRRRWRQRWQQILALADRIYSFPDPPVDTPLDLAIQQLQGLAIEELPDPPTSAPEPLNDVAKSP
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: THAF_BURTA
Sequence: MFSGQGSQYVGMGRALYESEPTFRHHVDRFDEVTRDKTGTSLVARLYGRDARAGEPFDDTHVTHPALFAVQYALARTLQARGAQPDIVLGSSLGDFVAAALAQVAPAQEIVAWLIDQAASMARACEPGFMLAVLGPASIYRGSDTLREFSDLVGVNYAEHFVIGGNRADLVRVEAALAREGVVFHRLPVRFGFHSRNVAPVVPWLHAREANLSCRAPTIPWASCTAGGIVEAPTARFLTRIAIDPLRFQEAARAIEQTGSPDTLHWVDLGPSGTLANFARRLGVPNDRLHVVMGPFGDDARALGRVSNLHASNARPAGAPAAPVSEGVSMHAFLFPGQGSQVKGMGAALFARFPDRMRLANEILGYDLAALCIENPDNRLGQTQFTQPAMYVVNALAYLARREDDAGAPAFVAGHSLGEYSALFAAGAFSFEDGLRLVKKRGELMSAARDGGMAAVLGLDEARVAEILALSDLRGIDIANLNAPTQIVIAGPADEIRRAQQWFEQGGCYAYVVLPVSGAFHSRMMRDAQREFERFIAPFDIGAPGIPVIANVTGRPYRGDEVRRGLVEQIASPVRWVDTIRYLSEQGVERFAEIGTGTVLTDLLRKILPQKAGASGAAARPQAGAASAVAASAPPRPTGMADAQPPAASPARAATAASTMPPASASASASAPAPAPAPAPAPAPAPAPAPALAPAFARAPASTSTNGIAPAARVEQLGCPEFKRRFGLKYAYVAGGMVHGIASVRMVVAMAKAGMKGYFGTGGLSLDAIRDAVRAIRGALPAGEPYGMNLLSGRLEEATVDLYLREGVTSVEAAAYMHVTPALARFKLAGLSVDRDGATVSAHKILAKVSRPEVATAFMSPIPEKFLERFVRDGVISDAQARAARAMPVADAVCVEADSGGHTDMGAMPALLPAIRRLCADIAGERGYRDKVPVGVAGGIGTPEAAAAAFVLGADFILTGSINQCTVESGISDVVKDMLQQINVHDTDYAPAGDMFELGAKVQVLRRGVFFPARANRLYELYKQYDSVDDLPDAVRRQLEDKYFGKSLAEVYADCERYYPADEIERARGNPKQKLALIFRWYFGFATRAALAGNEADKVNFQVQCGPALGAFNQWVRNTALENWRNRHVAEMAARILQDAADLLSRRYLSMVGR
What is the function of this protein?
Involved in production of the polyketide antibiotic thailandamide (Probable).  Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity (By similarity).
What are the official names of this protein?
Polyketide biosynthesis protein ThaF.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FabD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA3_PICPA
Sequence: MVTKDSIIRDLERENVGPEFGEFLNTLQTDLNSEKPPIEQVKSQLETHFNLAHETQEFSRKNDNAPVDKLLTNYYNNYEVNVLEFVLQMGFSRDLSIPLNVWFVLDMISQLSTSKQDLPLDYYLVLNNSQTGKYSDFVRYLIYEAVGAEIHCFEQGSMPEQYRSSRWEDKVKGPALANRGPIRGNVGAGDRKITFHLLCKKTARMILVGDDRETDFEMSDRSFVTLLLDYYQRVGTTKKIDLLLLTNNFDTNMNNKLQQLKILESLNMLKSNCYVLDYQITVDQVTANFNSYVEGIPAFRRHEIANFLKKRKTPKNADELIFKYVGRWNICYQKKFHQGNISIHQISGYLD
What is the function of this protein?
Structural subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase.  Not required for catalytic activity.  Fine-tunes allosteric regulation of the ATP-PFK by ATP, fructose 2,6-bisphosphate and AMP.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase subunit gamma, ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase 3, Phosphohexokinase.
Protein: RNPH_PSESM
Sequence: MKRPSGRAADQLRSIRITRNYTKHAEGSVLVEFGDTKVICTVSVENGVPRFLKGQGQGWLTAEYGMLPRATGERNQREASRGKQGGRTLEIQRLIGRSLRAALDMSKLGDVTLYVDCDVIQADGGTRTASITGAMVALADALKVIKKRGGLKGGDPLKQMIAAVSVGMYQGEPVLDLDYLEDSAAETDLNVVMTSAGGFIEVQGTAEGAPFQPEELNAMLALAQKGMTELFEMQRAALAD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RS2_GEOUR
Sequence: MSNITMKELLEAGVHFGHQTKRWNPKMKPYIFGARNGIYIIDLQKTVRLFKGAYNFVVDAAQSGETMLFVGTKKQAQDSVSEEAQRCGMFYVNDRWLGGMLTNFSTVKQSIDRLKRLDAMVADGTIEAYTKKEALQMEKDRQKLEKTLGGIKGMNKLPGVLFVIDPKNEEIAVSEAKKLGIPVVAIVDTNCDPDDIDYVIPGNDDAIRAIRLLTSKVADAMIEGGQARNIKLQTDTEGAEFAAEAEGVVEETAGEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PACA_HUMAN
Sequence: MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
What is the function of this protein?
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.  Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.  In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity).  Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide, PACAP.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEY1_VANPO
Sequence: MDSKEEAIQLITEEKHFSDDALAYFKTCIGGRDVGVNYHVISVFGSQSSGKSTLLNILFNTSFDTMDAQIKRQQTTKGIWVAHSNELLSNVDVNPEDKSDLFILDVEGSDGLERGEDQDFERKAALFAISVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKNKNGHKVLLLFVIRDHVGVTPISSLRDTITTELINLWETLSKPAECENKKLSDFFELQFVGLSHKLLQEERFVQDVKSLGDHFIMKDNEDYYFKPEYHHNLPLDGWTLYAKNCWELIEENRDLDLPTQQILVARFKTEEILNDSLEVLKSKYDSNVDPVIKDKLKLIQELSVLKTECLDMYDQHASKYVSAVYLEKRDELEAKIYLKFLETITLFIDSVSQDIFLQLVEDVNSESSKEPIFSKRLSNSTEVAKSKFEDIIEEFAAAKILSEEVKEEVVKRFENDLKETSDKLRVTALQKLITRSSKIINARIKDVVPQLLSNPDVDVWDRIMDKFHSIFSSTLIKYKLDDDTYDFQFGGEDEENNSTYKSIRVAAWKSLNDTIHDYLKEDTICNILRDRFELKFRYDDEDSPILWKNEEEVDLAFRVAKEYAFKIFDVLALIKTSDNVEVVPDINFHDSDEMYEDDLGIYHSAKFSHILNEVQKEKIQIQVRRQINVTVLDAKRSMIKTTTHIPLWIYAIIVVLGWNEFMMVIRNPLFVTLTILILVSFYFINKFDLWGPVKSVAQTAAGETIGTIKTKLRDFVLEEHEKTPKIQSEKSNSDSEKVVENEKS
What is the function of this protein?
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: ZAPB_SALNS
Sequence: MSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLTQEVQSAQHQREELERENNSLKEQQSGWQERLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern.
Protein: RL24_PAEAT
Sequence: MAKIKKGDLVQVITGAKQERGGDRGKQGKVLRVFPDTNRVLVEGINRVTKHSKVGQSQRGTKTGGIEVVEAPIHVSNVALVDPSTKKPTRVGFRLDTVEKDGATKTVRIRVSKATGKDI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ACH10_CHICK
Sequence: MGSAPLPACLLALSLAGTVLAPGCGAAQGRLAHKLLHDLFANYSSALRPAEDTERALNVTLQVTLSQIIDMDERNQVLTSYLWVRQAWLDAHLAWDKDAYGGIDSIRIPSSYVWRPDIVLYNNADERFGGSMETNVVLRSDGHIMWDSPAITKSSCKVDVSYFPFDGQQCRLTFGSWTYNGNQIDLRNLLDTGDLTDFVENVEWEVLGMPATRNVVTYGCCSEPYPDVTYTLLLRRRASFYIFNLLLPCVMISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLLVAESMPPSESVPLIGKYYIATMTMITASTALTIFIMNIHHCGPGARPVPPWARRLILHHLARALCVCEVGESCGRPQREGTGGMGPRDPPGEGVEPGLCPRSRCLCHHHAVLSSVGYIAGVFRRHRTAQRRAAEWKKVAKVMDRFFMWVFFLMVFLMSVLVIGKAA
What is the function of this protein?
Ionotropic receptor with a probable role in the modulation of auditory stimuli.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-10, Alpha 10 nAChR, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: PTXA_BACSU
Sequence: MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDTVKKGEVLVEFDKAFIEDIEESALHQKIFTVVS
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
What are the official names of this protein?
Putative phosphotransferase enzyme IIA component YyzE, PTS system EIIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1220_AQUAE
Sequence: MMKKFLLVLIPVLILYFYNLGYNAVWMPNESFYADSAKNMLKSGEFLTPVYNGEIRLNKPPMTYWIVSLGYKIFGVNELGLRFFHALLGVFTGVLTYLLARRITGSKNTALLSFLILSLSFIFIANARYASPEVPFTFFITLSLYLWYEYFTRKKEFLFWLALIASSLAVLTKGPAGFVLPAGVVFFYLLLRAPKELLKIKYYAGTLMVFLLSGWWFLYQYLVHREEFLEVFIKENVKRIYALQRDPFYFYALDINVSFLPYSFLFFFALFWALKEKRRELSFPLVWFSFIFLIFSIVKMKIPVYIMPAYPAMAIITADFLNSQSLKKVKNLSLIFLWTVLVLATLALSLYFKFSATLFPLIPLLLLPFFLKKYELLPAFGAFAFLFYLSSVILPYVEQFRPYREVGKEIRKLDPKNELRTYELGFFHHNLPFYADRVIIRRTKEVKKPAIVLARKGSFDCEPVRKWELYTSSESRFFKFMLDIKRKKRFEEFLLCVIK
What are the official names of this protein?
Uncharacterized protein aq_1220.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 39 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL14_COLP3
Sequence: MIQMQSQLNVADNSGAKRVQCIKVLGGSHRRYARIGDIIKVAVKEASPRGKVKKGDVHTAVVVRTKKGVRRTDGSAIRFDENAAVMLNANLQPIGTRIFGPVTRELRNEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CWP02_DAUCA
Sequence: QLAELKYVI
What are the official names of this protein?
58 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: MBTM_MYCTU
Sequence: MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVAAWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGSTGAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLWLAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHKHAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGDLGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPGLVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSLEMAD
What is the function of this protein?
May play a role in virulence by supporting bacterial growth in the liver.
What are the official names of this protein?
Medium/long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM, Fatty acyl-[acyl-carrier-protein] synthetase, Fatty acyl-ACP synthetase, Mycobactin synthetase protein M.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: MTNN_ECOL6
Sequence: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: Y1287_MYCTO
Sequence: MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSGPTTALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHGD
What are the official names of this protein?
Putative HTH-type transcriptional regulator MT1325.
Protein: LSPA_BORBU
Sequence: MSAKSKQYFNIFVFIISLIFFDQLSKYLVAKYVKLGSIYFSFFDDFFRIIHVRNTGILFSMGSNIHYSLKKIFFLAMPIFILIFVFYLSLKERNCIARISLLLIFSGGVGNVIDRLFRPSGVVDFLDLKFYGIFGLDRWPTFNFADSYVVIGMILFLVYDFFIKRKVLNK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ALMT9_ARATH
Sequence: MAAKQGSFRHGILEKRERLLSNNGFSDFRFTDIESNDLLENENCGRRTRLCCCCSCGNLSEKISGVYDDAKDVARKAWEMGVSDPRKIVFSAKIGLALTIVALLIFYQEPNPDLSRYSVWAILTVVVVFEFTIGATLSKGFNRALGTLSAGGLALGMAELSTLFGDWEEIFCTLSIFCIGFLATFMKLYPSMKAYEYGFRVFLLTYCYILISGFRTGQFIEVAISRFLLIALGAGVSLGVNMFIYPIWAGEDLHNLVVKNFMNVATSLEGCVNGYLRCLEYERIPSKILTYQASEDPVYKGYRSAVESTSQEESLMSFAIWEPPHGPYKSFNYPWKNYVKLSGALKHCAFTVMALHGCILSEIQAPEERRQVFRQELQRVGVEGAKLLRELGEKVKKMEKLGPVDLLFEVHLAAEELQHKIDKKSYLLVNSECWEIGNRATKESEPQELLSLEDSDPPENHAPPIYAFKSLSEAVLEIPPSWGEKNHREALNHRPTFSKQVSWPARLVLPPHLETTNGASPLVETTKTYESASALSLATFASLLIEFVARLQNVVDAFKELSQKANFKEPEIVTTGTDVEFSGERVGLGQKIRRCFGM
What is the function of this protein?
Vacuolar malate channel.  Has a higher selectivity for malate than for fumarate.  Exhibits also a weak chloride conductance.
What are the official names of this protein?
Aluminum-activated malate transporter 9, AtALMT9.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter (TC 2.A.85) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: RNPA_LIMRJ
Sequence: MRKSYRIKKESEFQRVFETHNSVANHKFVVYQMEKPGQKHFRVGISVGKKIGNAVHRNWVKRRIRQTLLEVKPQLRSDVDFLVIARSAADGLSMAETKKNLVHVLNRAHLLDEKSED
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RS6_SYNY3
Sequence: MLVNSYELMVILRPDLNEERVSQEVTKYQEFLTNNAAEEVSVKVWGKRRLAYQIRRFNDGIYVLFNFNGEGQQIALIERDMRLNDNVMRFLSIKLTPEKPEKEKKAKAVAVEA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RNZ_LEUCK
Sequence: MQLEFLGTGSGQPSKFRNVTSIALRLLDERNAVWLFDVGEATQHQILKTTLRPRKVEKIFISHLHGDHIFGLPGFLSSRSFQGADKNEPLTIYGPKGVKEFVQTALRVSETRLSYPLVFVELTAGVVFDDKTFRVIAAKMKHRIESWGFRVEEKDHPGELLVNKLRAENIPSGPIFGQLKAGKRVSLPDGRILDGHDYVGPAQRGRVVTFILDTRPNDNIELLARHADVLVHESTYGAGEDEAKMARAHAHSTSINAANNARRAQANQLILTHLSARYIGPLLKNLVSDVRHVFPNTIVARDLDVIDVPLKKEVSVSDPHKV
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: CPSE_STRA3
Sequence: MIQTVVVYFSASLTLTLITPNFKSNKDLLFVLLIHYIVFYLSDFYRDFWSRGYLEEFKMVLKYSFYYIFISSSLFFIFKNSFTTTRLSFFTFIAMNSILLYLLNSFLKYYRKYSYAKFSRDTKVVLITNKDSLSKMTFRNKYDHNYIAVCILDSSEKDCYDLKHNSLRIINKDALTSELTCLTVDQAFINIPIELFGKYQIQDIINDIEAMGVIVNVNVEALSFDNIGEKRIQTFEGYSVITYSMKFYKYSHLIAKRFLDITGAIIGLLICGIVAIFLVPQIRKDGGPAIFSQNRVGRNGRIFRFYKFRSMRVDAEQIKKDLLVHNQMTGLMFKLEDDPRITKIGKFIRKTSIDELPQFYNVLKGDMSLVGTRPPTVDEYEKYNSTQKRRLSFKPGITGLWQISGRNNITDFDEIVKLDVQYINEWSIWSDIKIILLTLKVVLLGTGAK
What is the function of this protein?
Galactosyl transferase is essential for the assembly of the group B streptococci (GBS) type III capsular polysaccharide.  May be involved in the formation of either or both galactosidic bonds by catalyzing the addition of galactose to an oligosaccharide precursor or to a lipid intermediate.  Type III capsular polysaccharide consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid or sialic acid.  The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule.
What are the official names of this protein?
Galactosyl transferase CpsE.
What is the protein family that this protein belongs to?
Belongs to the bacterial sugar transferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECO_CHLT3
Sequence: MIRKTQAIVLRTINYGDQSKIVTFFTRSFGKLTGLVKGYRNPKGKFASVLEIGNDLDLVLYKKDTREVQLITEAVLRAPMLGATSSLEQLSALHQTLELIRLTTENDDAHLGVFELLHATLQKINVSRKNHISFFFYFQVQLISLLGFRLNFQKCVLTGKSLSEKALPKDARVVLLAEHGGFALQLAAEERGFAGMPVSTDAFKAVQWLSLVAIESVENLFLEKLVINEIFQLLDSYFRFHIDDLPAFRSREIFNQLVF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: TRML_LISMF
Sequence: MPNHIVLYQPEIPANTGNISRTCAGTDTYLHLIRPLGFSTDDKMLKRAGLDYWDNVKLSYYDSLDEFFEKNEGGEFYYITKFGRHVYSDIDYSDPNKDYFFVFGKETTGLPDALLQKNEENCLRIPMTDHIRSLNLSNTAAILAYEALRQQNFGALLQEPNYDRKIFQD
What is the function of this protein?
Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
What are the official names of this protein?
Putative tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESX1_HUMAN
Sequence: MESLRGYTHSDIGYRSLAVGEDIEEVNDEKLTVTSLMARGGEDEENTRSKPEYGTEAENNVGTEGSVPSDDQDREGGGGHEPEQQQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRPPIAPMPPMAPVPPGSRMAPVPPGPRMAPVPPWPPMAPVPPWPPMAPVPTGPPMAPVPPGPPMARVPPGPPMARVPPGPPMAPLPPGPPMAPLPPGPPMAPLPPGPPMAPLPPRSHVPHTGLAPVHITWAPVINSYYACPFF
What is the function of this protein?
May coordinately regulate cell cycle progression and transcription during spermatogenesis.  Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase.  ESXR1-N acts as a transcriptional repressor.  Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression.  ESXR1-C has the ability to inhibit cyclin turnover.
What are the official names of this protein?
Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.