PharMolix/UniProtQA huggingface dataset:
Protein: MTND_LEPBP
Sequence: MATIVKKQETIQDKDQVKAYLTQKGLVYESYKTPESLDLILGQKGLSDAEKEEVLSGLEYRFDQLKKQHGYKANDLVVLHDEVPGISDMLAKFDKLHIHTDEEVRYIIDGSGIFGFIIDGERFEVHVGKGDFISIPANTNHWFTLDQTMRIKAVRYFKDNSGWTPVYVDESKVLINA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: GUAA_CORJK
Sequence: MTQQDPAAAAPRPVLVVDFGAQYAQLIARRVREVNLYSEVIPHTMPADEVAAKNPAALILSGGPSSVYADDAPSLHPELLELGVPVFGICYGFQAMTQAMGGTVAKTGLREYGRTELQIQSEAGVLHEGMGESQQVWMSHGDSVSEAPEGFTVTARTEGAPVAAFECPEKRMAGVQYHPEVLHSPKGQEVLRRFLLETAGLEPTWTAGNIAEQLIEQVREQIGDEGRAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDEREAFLQKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLADAPEGSSVDFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPDDVEFELVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIIGEVTEDRLETLRAADAIARAELTAAGLDDVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRIPFDVLEKISTRITNEVEEVNRVVLDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: MEE8_ARATH
Sequence: MNKDEVFLRQWFEILYSLTNPEANSDLRRINNEKGVEKVGQKRSAESRREGKKKRVKTQCVIKSSDKSDHDTLLKKKRRERIRRQLETLKEITPNCPQSDINAILDCVIEYTNNLRLAHYKGSQGICDDWRLFTEAGAVLYYIDT
What is the function of this protein?
Required during early embryo development, for the endosperm formation.
What are the official names of this protein?
Transcription factor MEE8, Basic helix-loop-helix protein 108, AtbHLH108, bHLH 108, Protein MATERNAL EFFECT EMBRYO ARREST 8, Transcription factor EN 132, bHLH transcription factor bHLH108.
What are the subcellular locations of this protein?
Nucleus.
Protein: YD543_YEAST
Sequence: MAHLSLNQYKCTHIIIHGTCLSGLYPVPFTHNAHDYPHFNIYISFGGPKYCKTALNTYVIPLLHRILTTQFIYTYANITEKSPPKSPKHKNILSFNNNT
What are the official names of this protein?
Putative UPF0320 protein YDR543C.
What is the protein family that this protein belongs to?
Belongs to the UPF0320 family.
Protein: PEX3_YARLI
Sequence: MDFFRRHQKKVLALVGVALSSYLFIDYVKKKFFEIQGRLSSERTAKQNLRRRFEQNQQDADFTIMALLSSLTTPVMERYPVDQIKAELQSKRRPTDRVLALESSTSSSATAQTVPTMTSGATEEGEKSKTQLWQDLKRTTISRAFSLVYADALLIFFTRLQLNILGRRNYVNSVVALAQQGREGNAEGRVAPSFGDLADMGYFGDLSGSSSFGETIVDPDLDEQYLTFSWWLLNEGWVSLSERVEEAVRRVWDPVSPKAELGFDELSELIGRTQMLIDRPLNPSSPLNFLSQLLPPREQEEYVLAQNPSDTAAPIVGPTLRRLLDETADFIESPNAAEVIERLVHSGLSVFMDKLAVTFGATPADSGSPYPVVLPTAKVKLPSILANMARQAGGMAQGSPGVENEYIDVMNQVQELTSFSAVVYSSFDWAL
What is the function of this protein?
Involved in peroxisome biosynthesis.  Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery.
What are the official names of this protein?
Peroxisomal biogenesis factor 3, Peroxin-3.
What is the protein family that this protein belongs to?
Belongs to the peroxin-3 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: BAZ2_CAEEL
Sequence: MSDNSSNQFLLLLAAAQQQQQQQLLQQQLAKIQKATASSPSKSTNGTSASTSAVPSTSGTSSSQNEAAQLQNLAKMQQIQQLAQFGALMAAQKKQQEKAAADKAKEKEKEKQKAAAAAAAAAAKASASTSSASAIPGLSPEMLAAWQQAIQMQALQQMMMTPQKSQMEEAIKKMMDMAKKKPAGVASTSSASTSSSTPSTSSASITSSNNNAANNAASNMMNNVMWQLVAAQMQQKQQQQQKDTQKKADQAKKAKELAKQQQKEQDVKNKQQEEILKFLMAQHQLNHQKKHEKKQADAAALAAKVLAAHRAALESDSPEEGKKTNEAMLRLPLQLGWRRQTCVRSIASAGVKGDVSYFAPCGKKLSTYSEVVRYLTKNSIHYITRDNFLFNTKLVIGEFIVPKQTEADETQQEREFAMFTEDDINKELTRLNVLKFVPKIQASTSNGVHEDDIKMSKIEEPDEPLDPSELNDEFTEELVHSQIMSNGVDECKIREREADDLLVNINDVRHLPDFSRIGNQCLSSQGFADALMVHEFVQNFGHVLGIDLEIAPKLESLCAGLDGDANHAEQTLQLTRQLLRLALEFPGMGNEKRFGQGGGEMGLDRENFSEVMRLFLIDKGKRGEELSQPLLTCNFLSISPEQKASILAFLCDELVCSRNVVTEIDKNLDEISRLKGEKWMREGKARALRSARSKKKNDEKVVVVKEEQNHESDSEPPTRPDTPKKATVAPPTVVSVSPVSAAQQQQRKFTPGLGQCEVLTEQEESMSLQQMDSLIGDLHQEAQNINQKIHDTGLKIRSFPFGTDRFHRNYWMLAHTDKVIIESLATTSVNNPACNANEYASKDPPTLEQRVPGACETIDLDVIACVEDLVDDVVLLRAKADKKTRKRYRRIENHMKRGWWTMQNRDCVESLRSCMLSRGIRERALHRLLTKPWFLNELKFGTITIEPVGEKSDLELVRRQGWTRLNTAIDKLQCHLKMSDVSKPLPSITPFETQKPIVVPPTMALAQIVKDDMAWKVIDEEVDGQELDETIIRQKIIETADMVQPKFWRPKFQKLEDQDTCQLFEDWKSYVSTEAQTTSQLMVALQTLEGMIMWERSSREALCQICKSMDGDEMLVCDGCESGCHMECFRPRMTKVPEGDWFCQRCREEKSGRPMCMFCSRETGNLHQCQRCAYHVHQECSQDGPKEAINPETFICGHCQEMKQMRFVKRLILRSESEERELEDDNHAENGENTKNGHMNGMNGAIAIGVHNQQNGVKGNLKRKLEVPSIGGLPKNMNKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEKLIYETPEDFAEDIELMFANCRQFNIDHSEIGRAGISLHKFFQKRWKQLKYNFTKRLRRLHR
What is the function of this protein?
Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178).  Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178).  May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178).  Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).  Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178).  Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).  Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
What are the official names of this protein?
Bromodomain adjacent to zinc finger domain protein 2.
What is the protein family that this protein belongs to?
Belongs to the WAL family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ASSY_BURCH
Sequence: MSTILESLPTGQKVGIAFSGGLDTSAALHWMKLKGAVPYAYTANLGQPDEDDYDAIPKRAIEYGAAGARLIDCRAQLVAEGIAALQSGAFHITTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQTFIDELGGRAEMSEFMNQAGFAYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIAAEEVTVRFEAGQPVALNGVEFKDQVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAITGEVKIELRRGNDYSILSTKSPNLTYQPERLSMEKVASTFSPRDRIGQLTMRNLDITDTRDKLRVYSQVGLLTPGETSALPQIKGDGDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1226_STAAM
Sequence: MISKINGKLFADMIIQGAQNLSNNADLVDSLNVYPVPDGDTGTNMNLTMTSGREEVENNLSKNIGELGKTFSKGLLMGARGNSGVILSQLFRGFCKNIESESEINSKLLAESFQAGVETAYKAVMKPVEGTILTVAKDAAQAAIEKANNTEDCIELMEYIIVKANESLENTPNLLAVLKEVGVVDSGGKGLLCVYEGFLKALKGEKVEAKVAKIDKDEFVHDEHDFHGVINTEDIIYGYCTEMMVRFGKNKKAFDEQEFRQDMSQFGDSLLVINDEEIVKVHVHTEYPGKVFNYGQQYGELIKLKVENMREQHREVIRKEQHTAKPKMETVETAIITISMGEGISEIFKSMGATHIISGGQTMNPSTEDIVKVIEQSKCKRAIILPNNKNILMASEQAASIVDAEAVVIPTKSIPQGISALFQYDVDATLEENKAQMADSVNNVKSGSLTYAVRDTKIDGVEIKKDAFMGLIEDKIVSSQSDQLTTVTELLNEMLAEDSEILTVIIGQDAEQAVTDNMINWIEEQYPDVEVEVHEGGQPIYQYFFSVE
What are the official names of this protein?
Uncharacterized protein SAV1226.
Protein: KLK6_HUMAN
Sequence: MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
What is the function of this protein?
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position.  Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen.  Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies.  May be involved in regulation of axon outgrowth following spinal cord injury.  Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
What are the official names of this protein?
Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
Protein: TATB_HAES1
Sequence: MFDIGFSELVLLFVVGLIVLGPQRLPVAVRTVMGWVRTVRSLATNVQNELSQELKLKELQESIKKAEDLNISQLSPELSETVEELRQSAQKIKMNLEEKAAETNSSVEEQVQELKSAVQNSQGTATTEIEKNFDFPSGELSPAELAELAEEGEPMLEMGESDFSEDEQATASSNETIENIKEKV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GLYA_PYRCJ
Sequence: MIPREIKEVLDVVLRHNRWRRWETINLIASENVMSPLAEIFYINDFGGRYAEGTIGSRYYQGTKYVDVVEEALVKEFAEVLGAKFVDVRPISGTVANLATYFALVPEGGSVASLPIRCGGHISHSNVGGLKALRIKTVELPWDLENFNVDVDAARKVLEDKRPNLVILGGSLYLFPHPIKEVAEIAKGIGAYVLHDSAHVLGLIVGGVFPNPLREGADVITSSTHKTFPGPQGGLIATNLGDDANGQIQKAVFPTFTSNYHLHRYVATYITLVEMKLFGHEYASRVVENAKALAEALAEEGVTPVAERLGFTKTHQVAVDVSKYGGGDKVAALLEEANIIVNKNALPWDRSVVKPSGIRIGVQEMTRFGMGKDEMREIAKFIARVLRGEDPASVRRDVVDFRRGFVEVKYGFKASREVIEEVFASLNLLA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX1_LEIIN
Sequence: MDTRFHCVYLLTSLDPQCEGDFYIGYTVNPLRRLRQHNGELVNGARRTSRRGRPWTIVCCVSGFPDDRAALKFEWCWQHPTASARLRHAIDILTGLRRLPYAVATLHLLVRASLFCRLDLTLHIFESALLQEAAARAEVLLARRRGAFAVGGGLRASSPRVGTQQHSQRSSSLQGQADGVATPPLPALDSKGELQDASTAAALATTTAASHLLPPLTPSLLFHVEDTTRQAFEDAYLSHDRCLLLPSVGMGVDVGEAGKEGSHMSASAGTSCPYDVSLLSQAARAEWSNASFASDSDDEDTRRFAPYCPSTGSRTPSPQRVHTAASPALLGYRSEERAGDGVLEASPGSSIGCGAALRSFSSPPPPRASSPRSASCPPLYTGINASASLAVDAPHGGVTDACTSSPAAAPAPQPRIPLRFADYGEVDFARAHAEEQHRLHHGLLPCSLCTLPLQPSCVAYCSRAPFCTLRCHLSCLAMWMLYAEAEAAATVDGTDKSPALLSQAPPAPISPLRRLIPSQPCPCPLCGVLLHWGSLVKELKKRVVVERRLHAAQRRIRMEQRWQARLAHIDHTKRSTSAAMRRRQRTRVGAAALAKGAGEAPGAASTVRASTMHVGPARRDAPRVSSPSCLGEPTLTSFAAAASCPSPSTSLAALSPAASASPISRHNGHSNTVTATNTAVAAAAAVSDASLLSLTDFCEEDWLLP
What is the function of this protein?
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_VEREI
Sequence: MHIGIDIVEVPRIAKALNRGDKGFLNAVYTAGEAAHIEQAHAGDVRAAGIWAAKEAVVKAFGVGFSEGVTFRDVEVRYTATGQPQAVLSGKLASLAVDRSLQVLSISISHTENYAAATALVGPVSAEVRPV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANR1_ARATH
Sequence: MGRGKIVIRRIDNSTSRQVTFSKRRSGLLKKAKELSILCDAEVGVIIFSSTGKLYDYASNSSMKTIIERYNRVKEEQHQLLNHASEIKFWQREVASLQQQLQYLQECHRKLVGEELSGMNANDLQNLEDQLVTSLKGVRLKKDQLMTNEIRELNRKGQIIQKENHELQNIVDIMRKENIKLQKKVHGRTNAIEGNSSVDPISNGTTTYAPPQLQLIQLQPAPREKSIRLGLQLS
What is the function of this protein?
Probable transcription factor.  Required for root plasticity in response to nitrate, NO(3)(-).  Promotes lateral root growth in a NRT1. 1-dependent manner.
What are the official names of this protein?
MADS-box transcription factor ANR1, Protein AGAMOUS-LIKE 44, Protein ARABIDOPSIS NITRATE REGULATED 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y478_STRPI
Sequence: MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVSWLVFTGSLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEDNQMKLSRFKQVDFVKYAYPRYEHKGQLRDYQQFLLENTNSSYLFYDEENETKLAYFYQKMKNQEDYFIKRLTFDQLNELAENFSEN
What are the official names of this protein?
UPF0398 protein SPH_0478.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: ATPE_BRUSU
Sequence: MAQAFQFELVSPERLLLSAQVTEVVIPGSEGYLTALAGHSPLMTTIMPGVVSVKLADGKTDSYVVFGGFADITPQGCTVLAESATHVDDIDPADIQHRIDHARKVLEDASSNEHRTKAEIFLHQLMTLQGAILPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GCSH_ALKEH
Sequence: MTQVPDNLKYNRTHEWTRLEDDGTLTIGITDHAQSELGDLVFVETPTVGRHYDAEEACAVVESVKAASDIYAPVGGEVIEANSELQDSPELVNTDPYGEGWIMRIRPDDSDDLEQLLDPEDYQDLVADEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SERC_MYCTO
Sequence: MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVAVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_BORGP
Sequence: MSKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSLLDIENRMREILKTGSSFEKEIISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFIDLCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRIYGTLWNNEKELRSYLNLREEIKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPHVGKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGMMRARGFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSLKAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDKGGGAFYGPKIDLKIVDSLEREWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLWLSHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFIIGEREAIEERISIRTRTNEQINGIELDEALKLILLKVRDKEIS
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPTP7_PLAF7
Sequence: MAKDSQKNLNVSNNNNVQCTMGRSSQNINKSDSKGKIKRCTYAYKILLCTIFIWICQCFYNKSYYVYKKDGRRNKGKKILGIRINKSLAEMDHTKYHPEYYDEVQENYDPYYGVNQYSDECESYKSEDDDSEEEYYNSTPRVTVLEPQTENSEDEENYEKTIVDELNELPNDKKALILSYIRNGNDNNMQLLPYANNNKQNTQENISRNKEFFRHFVDFIKGYKLFDSPVLNALLPFIFIAFVYCTITMLVGNVRYIIALYILAKILKMHYDYKHKENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKKSKKN
What is the function of this protein?
During the asexual blood stage, plays an essential role in the recruitment and/or formation of EMP1-containing vesicles at the Maurer's clefts and their subsequent transfer to the host erythrocyte cell membrane.
What are the official names of this protein?
EMP1 trafficking protein-7.
Protein: VP2_ROTHW
Sequence: MAYRKRGAKRENLPQQNERLQEKEIEKDVDVTMENKNNNRKQQLSDKVLSQKEEIITDAQDDIKIAGEIKKSSKEESKQLLEILKTKEDHQKEIQYEILQKTIPTFESKESILKKLEDIRPEQAKKQMKLFRIFEPKQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQILIEMPDYLLLKDMAVENKNSRDAGKVVDSETANICDAIFQDEETEGVVRRFIADMRQQVQADRNIVNYPSILHPIDHAFNEYFLNHQLVEPLNNEIIFNYIPERIRNDVNYILNMDMNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEKELVSTEAQIQKMSQDLQLEALTIQSETQFLAGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVIPNDMFLRESLVACELAIINTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFINNNRFRQVVIDGVLNQTLNDNIRNGQVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLVSYNYETLMACVTMNMQHVQTLTTEKLQLTSVTSLCMLIGNTTVIPSPQTLFHYYNINVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDVPRVPDDQMYRLRDRLRLLPVERRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGYQQINLEELMRTGDYGQITNMLLNNQPVALVGALPFVTDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWIPTSTTKVYKQVPQPFDFRASMHMLTSNLTFTVYSDLLSFVSADTVEPINAVAFDNMRIMNEL
What is the function of this protein?
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices.  This capsid constitutes the innermost concentric layer of the viral mature particle.  It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini.  VP2 is required for the replicase activity of VP1 polymerase.  Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles.  May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.
What are the official names of this protein?
Inner capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP2 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: NRADD_RAT
Sequence: MLHNVSKGVVYSDTALKGQDGDREGMWVGAGGALAPNTSSLFPPEPPGASSNIIPVYCALLATVVLGLLAYVAFKCWRSRKQRQQLAKARTVELGDPDRDQRHGDSSVFVDSPHGLEPCIPSQGPHADLGCRLYLHIPQQQQEEVQRLLILGEPAKGWQGLAGQLGYQAEAVETMACDQDPAYALLRDWAAQEGSGATLRVLEDALTAIGREDVVQVLSSPAEGCSVV
What is the function of this protein?
Modulates NTRK1 signaling.  Can activate several intracellular signaling pathways, leading to activation of JUN.  Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity).  Both isoform 1 and isoform 2 promote apoptosis.
What are the official names of this protein?
Death domain-containing membrane protein NRADD, Neurotrophin receptor homolog-2, NRH2, Neurotrophin receptor-alike death domain protein, P75-like apoptosis-inducing death domain protein, PLAIDD.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.
Protein: CAS2_ACIET
Sequence: MRMLVFFDLPVVSKADRRAYTVFRRFLLNDGYDMIQFSVYGRILNGTDAAQKHMQRLLANLPSEGSVRVLTVTEKQFASMKLLVGLPLFQEKKVNAAQIALF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.