PharMolix/UniProtQA huggingface dataset:
Protein: PETG_PATWE
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RL39_HYPBU
Sequence: MAHFKPLGKKLRLAKALKQNRSVPIWVIIKTNRRFRDHPKRRHWRRTKLKA
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: ALR_SHESH
Sequence: MKPFPRAEISSKALQNNLARLREIAPGSKVMAVVKANGYGHGLLNVAHCLDNADGFGLARPEEALALREGGVKSKLILLEGFFSQVDLTTLVEHDIDTVVHNEVQLELLESSILAKPATVWLKIDSGMHRLGFTPEQFAAVYARLEACPQVAKPINLMSHFACADEPDNPSTKVQINLFNDLIKDLPGQRSLANSAGTLYWPESQADWIRPGIALYGVSPVIGDLGGNHGLMPAMELVSQLIAVRDHKAGEPVGYGSSWYAKEDTKLGVVAIGYGDGYPRNAPEGTPVWVNGRRVPIVGRVSMDMLTVDLGINATDLIGDDAILWGKALPVEEVAEHIGTIAYELVTKLTPRVAVCLD
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: RECF_HALH5
Sequence: MHIERLTLKQFRNYDELDVSFEPNVNVIIGENAQGKTNVIEAIYFLALAKSHRTARDKELIQWEAPFARIEGAFQKQNGPLSLHVVLSGKGKKVKVNGLEQRRLSDYIGAVNVVMFGPEDLNLVKGSPQIRRRFLDMELGQMSPVYLHQLAMYQKILLQRNHLLKQLFGKANSDPMLDVLTDQLIEVAVEVTKKRFEFIQLLQRWAEEIHQAISRGKEKLVITYEPSVHVSEQLNLSKLREGFYQAYEQKKERERQRGTTLFGPHRDDLVFFVNDKDVQTYGSQGQQRTTALSLKLAEIELMKETVGDYPILLLDDVLSELDDYRQSHLLHAIQHRVQTFVTTTNVDGIDHQTLQEATIYEVEQGSLKKKG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
Protein: KCC2_YEAST
Sequence: MPKESEVINSEFHVDVQDPERLNGHPVAKFINKLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSLGDDGDNDIEENSLNESLLDGVTHSLDDLRLQSQKKGGELTEEQMKLKSALTKDAFVQIVKAATKNKHKVLAGEEEDDSKKTLHDDRESKSED
What is the function of this protein?
Important in cellular regulation.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: IRIS_CATRO
Sequence: MSWWWKRSIGAGKNLPNQNKENGVCKSYKSVALVVGVTGIVGSSLAEVLKLPDTPGGPWKVYGVARRPCPVWLAKKPVEYIQCDVSDNQETISKLSPLKDITHIFYVSWIGSEDCQTNATMFKNILNSVIPNASNLQHVCLQTGIKHYFGIFEEGSKVVPHDSPFTEDLPRLNVPNFYHDLEDILYEETGKNNLTWSVHRPALVFGFSPCSMMNIVSTLCVYATICKHENKALVYPGSKNSWNCYADAVDADLVAEHEIWAAVDPKAKNQVLNCNNGDVFKWKHIWKKLAEEFGIEMVGYVEGKEQVSLAELMKDKDQVWDEIVKKNNLVPTKLKEIAAFWFADIAFCSENLISSMNKSKELGFLGFRNSMKSFVSCIDKMRDYRFIP
What is the function of this protein?
Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate.  Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities.
What are the official names of this protein?
(S)-8-oxocitronellyl enol synthase, Iridoid synthase, ISY.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. Highly divergent.
Protein: MUTS_PROMS
Sequence: MQEDTIIQKNLFAIGNDINEQKKITKIPENLSLEDLKKESQKRPRQRKNSTNLINKFKTDLISNNKNVCINEESYSYKTVSKLKLTPVMKHYVTLKEENKDRLLLYRLGDFFECFFEDAVLISNLLEITLTSKDAGKEIGKIPMAGVPHHAMERYCADLIKKNYSVVICDQLEKSSGNYGTPIKRGITRIITPGTVIEEGMLIAKKNNWISAIYLSEENSDESYEWGISKADVSTGELITLEGQSLSKLFDEIIKLDSSEIIVGSNTARDLLIKGNSQITYTVSQETNFGINEANYLIKNYFQIANLEGIGLKNLNNATRSLGGLLNYLEKINPSNLDKDSSLKISLDFPQIQYGHNKLIIDYQTQKNLEIKNTQRENNYVGSLLWSIDRTYTCMGARCLRRWIDSPLLNVNEIYKRQNIITNFLESKKLRIDTQNLLRAMGDLERLAGRACAGHASPRDLIAIAEGLKKLPRLKSIIELFKYDLPDWTDQLKNIDEGLLELADTISFKLVENPPLNISEGGMIHDGVDNILDGLRNLMDDYSEWLNKEESKERKISKISNLKIQFHKNFGYYISINKSKVNLAPQHWIKRQTLTNEERYITSEIKNKENKIFQIKSRASSKEYEIFCELRNIVAEKTKQIRSIAKSIASLDALLGLSITSVENNFIKPSLIPINDSMTKNSTKIIAGRNPIVEQLLSDKKFVANDISFEDNQKLIILTGPNASGKSCFIRQLGLIQILTQIGSFVPANNAEIKIADRIFTRIGAVDDQSSGQSTFMVEMSETASILNQATSSSLVLLDEIGRGTSTFDGLSIAWSVSEYLAKKIQCNTIFATHYHELNYLKNTNKNIQNFQVLVEQNNDQLIFSHRIVKGGSNKSYGIEAAKLAGVPKEVIEKAKSVLNSLEENNKLNYDIK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: VJBR_BRUA2
Sequence: MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV
What is the function of this protein?
Transcriptional regulator involved in the global control of Brucella gene expression (PubMed:28334833).  Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes (By similarity).  Binds with high specificity to a large number of sites distributed across the genome.  The VjbR-binding motif contains an asymmetric 16-bp consensus sequence, an unusual feature among LuxR-type regulators (PubMed:28334833).  May directly modulate expression of many genes, including virulence determinants, components of the respiratory chain, efflux systems, elements predicted to participate in ion transport and adaptation to stress, uncharacterized proteins, as well as transcriptional regulators probably responsible for the observed indirect VjbR-mediated effects (PubMed:28334833).
What are the official names of this protein?
HTH-type quorum sensing-dependent transcriptional regulator VjbR.
Protein: GLMU_ACTPJ
Sequence: MTQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELLQQRLSSEPVNWVLQAEQLGTGHAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKPANGIALLTVELENPNGYGRIIRENGSVVAIVEQKDANAEQLKICEVNTGVMVASGASFKKWLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKTQAEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRICAGCVLKNCEIGDDVEIKPYSVIEDAVVGKAAQIGPFSRLRPGANLAEETHVGNFVEIKNAQIGKGSKVNHLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVFVGSDSQLVAPVTIADGATIGAGATVTKDVAENELVISRVPQRHIQGWQRPTKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_STRZJ
Sequence: MKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAMLHEAGHELILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQIVSAQILLTQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDELKVGDNDTLSAQVAAMVQADLLVFLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTGGMLTKIKAATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLAFYAQSQGSIWVDKGAAEALSQHGKSLLLSGIVEAEGVFSYGDIVTVFDKESGKSLGKGRVQFGASALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_FRATF
Sequence: MSKLIYGLAGPTASGKTSLSILLAKKINAEIISVDSSLVYKGMDIGTAKPTLQEQDGIKHHLIDIIEPTGNFSVADFISSVNKLKKEIWARGREVLLVGGTMLYFKGLIEGLSALPESQAEIREALEYQKKAKGLQYLHQQLNEIDPQSAQKINPNDQQRIFRALEVIMISGKKYSELVKTSKVGGLDEDLKLCALVPNDRSILHKNIESRFRQMLDQGFLDEVQNLHKNPMLTKETTAIRSVGYRQAWEYLDGDISYDEFVKKGIVATRQLAKRQLTWIRNWQSSINIVAMENETKELDILKYFGYK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RS14Z_PEDPA
Sequence: MAKKSLVVKSERPAKFSTQTYTRCERCGRPHSVYRKFHLCRICLRELAHEGQIPGMKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: OPSD_LITCT
Sequence: MNGTEGPNFYVPMSNKTGIVRSPFEYPQYYLAEPWKYSVLAAYMFLLILLGLPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITMYTSLHGYFVFGQTGCYFEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIISFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVVIMVIFFLICWVPYAYVAFYIFTHQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDEDASSAATSKTEATSVSTSQVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  May use a mixture of retinal and 3-dehydroretinal as visual pigment (PubMed:5315587).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: PLK1A_PLARH
Sequence: MKLLGLLLLVFTFMALAFADEKDCIARGQKCVGENKPCCKGTTCMYYANRCVGV
What is the function of this protein?
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav).
What are the official names of this protein?
U-reduvitoxin-Pr1a, U-RDTX-Pr1a.
What is the protein family that this protein belongs to?
Belongs to the venom Ptu1-like knottin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CEMA_ARAHI
Sequence: MAKKKAFIPFFYFTSIVFLPWLISLCCNKSLKIWITNWWNTRQCETFLNDIQEKSVLEKFIQLEDLFQLDEMIKEYPETDLQQFRLGIHKETIQFIKIHNEYHIHTILHFSTNLISFVILSGYSFWGKEKLFILNSWVQEFLYNLSDTIKAFSILLLTDLCIGFHSPHGWELMIGYIYKDFGFAHYEQILSGLVSTFPVILDTIFKYWIFRYLNRVSPSLVVIYHAIND
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: TPTE2_HUMAN
Sequence: MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK
What is the function of this protein?
Shows no phosphoinositide phosphatase activity.
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2, Lipid phosphatase TPIP, TPTE and PTEN homologous inositol lipid phosphatase.
What are the subcellular locations of this protein?
[Isoform 3]: Endoplasmic reticulum membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Protein: TNR16_MOUSE
Sequence: MRRAGAACSAMDRLRLLLLLLLLLGVSFGGAKETCSTGMYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCSYGYYQDEETGRCEACSVCGVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWITRSTPPEGSDVTTPSTQEPEAPPERDLIASTVADTVTTVMGSSQPVVTRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
What is the function of this protein?
Does not bind NGF, BDNF, NTF3, and NTF4.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 16, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.
Protein: GSA2_ALKCK
Sequence: MGNWTKSIEAFKEAQPLMPGGVNSPVRAFKSVGMNPVYMKEGKGAKIKDIDGNEYIDYVLSWGPLILGHANDVVVEELKKATELGTSFGAPHEYETRLAKLVIERVPSIDVVRMVNSGTEATMSALRLARGYTGRNKILKFVGCYHGHGDSLLIKAGSGVATLGLPDSPGVPESVAQNTLTVHYNDVESVRYVFETFGDDLAAVIVEPVAGNMGVVPPEPGFLETLRTWTEENGTLLIFDEVMTGFRVGYTCAQGEFGVTPDLTCLGKVIGGGLPVGAFGGKREIMEQIAPSGPIYQAGTLSGNPLAMTAGYYTLSQLTKADYSEFARKAERLEAGLSAAAKQHGIPHSINRAGSMIGLFFTDERVYNFEKAQTSDLDLFAAYFRGMLAEGISLAPSQFEGLFLSTAHSNEDIEATIAAAERVFQAIATK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_CUPNH
Sequence: MQIDLNADLGEGCANDEALLALISSANIACGWHAGDAATMVQTVKWALERGVAIGAHPSYPDRENFGRTEMQRDPEHVYADVLYQIGALDAIVRAQGGELHHVKPHGALYNQAVRDPALARAIVRAVRDFDADLVFFGLAGSQMIDIAREAGLRVKQEVFADRGYNPDGTLVKRGSPGALHEDEEVALNQTLTMVREKRVRAIDGTWVPIQAETVCLHGDGAHALAFARRIRERLGAEGIAVRAGD
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: COX14_DANRE
Sequence: MVSGKRIADVGYRLFSGSMMLLTVYGGYLCVVRAQRYMQRKKQLELAAQSENTASEIIKE
What is the function of this protein?
Plays a role in the assembly or stability of the cytochrome c oxidase complex (COX).
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX14 homolog.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: TRI5_GIBZE
Sequence: MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQMLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSDDPHPAMLNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTMDFFEGCWIEQYNFGGFPGSDDYPQFLRRMNGLGHCVGASLWPKDLFDERKHFLEITSAVAQMENWMVWVNDLMSFYKEFDDERDQISLVKNFVTCHEITLDEALEKLTQETLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDARYRLHEIYEKVKDQDTEDAKKFCKFFEQAANVGAVAPSEWAYPQVAQLANVRAKDDVKEAQKPILSSIELVE
What is the function of this protein?
TS is a member of the terpene cyclase group of enzymes.  It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes.  It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
What are the official names of this protein?
Trichodiene synthase, Sesquiterpene cyclase, TS.
What is the protein family that this protein belongs to?
Belongs to the trichodiene synthase family.
Protein: CCR4_SCHPO
Sequence: MFNPRYTQGTIYPGAHPGLLTPDHQHAAILSVQNSPALENSNISEHWKQQIALATQSRSFSSPHQRAHNAAALARSGGPGFSMNYNARTGAFTGGPNAAGLSSLGGKYNTSSTTTTLTTSTTLNTSSGTTLNSTSKTTTSSVAVDDQKSKSDSKKERRDWTCLDLGGIGLRNVSTDLFKFSFLTELYINHNNLTRLPPEIGKLKNLVILDASGNSIKTIPPELGLLTELREVLLFDNMISVIPAELGTLFQLKILGIEGNPLQDVYKNQIMESGTAGLIAALRDGCPVGPPPPERGWEKLVSDDDDDVNDNVSTSVRDLTAADSNKPSTTSKNLKFTIMSYNVLCERYATSTLYGYTPSWALSWSYRKDLIMQELGGYNADIICLQEVDVENYDTFFAPQMSLKGYKGVHFPKSRVRTMNEVERRIVDGCATFFKTSKYVMHEKMVIEYNQAPSLRRQDIKLTSNMYNRVMTKDNISVITLLENKENGSRLIVANCHIHWDPQFRDVKVIQVAMLMDEIAQVATKFRNMPSKIPSDQLKDERPTYPEYLKIPILICGDFNSVQGSGVYDFLSSGSISQNHEDFMNNDYGEYTVNGRSHAFNLKSAYGESEALSFTNYTPGFKGAIDHIWYTGNSLEVTGLLKGVDKDYLSGVVGFPNAHFPSDHICLLAEFKVKQEKTPLPSSKFNNDKK
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).  Participates in the shortening of poly(A)-tails (PubMed:26942678).  Erh1-mmi1 complex-mediated recruitment of CCR4-NOT to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons (PubMed:26942678).  Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly (PubMed:26942678).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RES18_HUMAN
Sequence: MAVDVEFGVAGWWEAAAPLSPSAVAATFTETWPGSERAEPGRIQHPLWPGSSEGLQLLVCFLLLNSCPGGCSDTSAHDGQDQVGVGQLWPLQGFATPVFQHLQVVLQQIIPQGLFWKDDITQDAMIQKMEHASRLHPQEPCLKDGKALFPTKTTESPLAKVNRDQCFTSEVVSKALKQEVANPVKITYRCSYGGLDMMQAPGPSKEEIIYKIMRLLWATSYCGPQPCG
What is the function of this protein?
May play an important regulatory role in corticotrophs.
What are the official names of this protein?
Regulated endocrine-specific protein 18.
What is the protein family that this protein belongs to?
Belongs to the RESP18 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle lumen. Note=Found in the lumen of secretory vesicles (dense core vesicles, DCV). However, seems to be retained intracellularly and not secreted.
Protein: TACC3_HUMAN
Sequence: MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI
What is the function of this protein?
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.  Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).  Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge.  The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).  May be involved in the control of cell growth and differentiation.  May contribute to cancer (PubMed:14767476).
What are the official names of this protein?
Transforming acidic coiled-coil-containing protein 3, ERIC-1.
What is the protein family that this protein belongs to?
Belongs to the TACC family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
Protein: YFAE_ECOL6
Sequence: MARVTLRITGTQLLCQDEHPSLLAALESHNVAVEYQCREGYCGSCRTRLVAGQVDWIAEPLAFIQPGEILPCCCRAKGDIEIEM
What are the official names of this protein?
Uncharacterized ferredoxin-like protein YfaE.
Protein: MAMP_MAGSA
Sequence: MNSKVALLVVGLAVVLALVIGRQGPVAPQATNTQSQAVAAGPVAAPVAFPQPLYPQAANVAMPVEPDPAAGGGTAPATESPLPNFVPRKLKVFEGHWQGMDGRLMTEELARKLNYPRGLQGVLLGEVTLNAAFSGLLAGDLIVRIDDTPVTDMESFKAASRTVANRSDARISVLRKDNRPGAPVVRKLTVVLREAEGGLGFAQLEGAPMILAGDPRPHGYRGACTDCHPIGQGFELTPDPDLISLPPPTITRDMVARSVNPHEVRGPCEACHVIK
What is the function of this protein?
Involved in redox-control of magnetite formation; oxidizes Fe(2+) to Fe(3+) or to mixed-valent Fe(2+)-Fe(3+) oxide minerals (PubMed:25775527).  May control magnetite crystal size and number (Probable).  Overproduction of MamP leads to more crystals than normal during exponential growth of normal size; in stationary phase crystal numbers become wild-type (PubMed:25048532).
What are the official names of this protein?
Multi-heme protein MamP, Magnetochrome MamP, Magnetosome-associated protein MamP.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamP family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Not seen in magnetosome membranes.