Protein: CNOT1_XENTR
Sequence: MNLDSLSLALSQISYLVDNLTKKNYRASQLEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQKSLKPSPHLFAQLSKVLKLSKVQEVIFGLALLNSSSCELRGFAAQFVKQKLPDLLRSYVDVDVSGSQEGGFQDIAIEVLHLLLSNLLFGQKGAFGVGQEQIVAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILADSGGITKTMMDSSLADFMQEVGYSFCASVEECRNVIVQFGVREVTAVQVARVLGMMARTHSGLTDGIPLQSITSPGSGIWSDGKDKNDAVQPHTWNVEVLIDVVKELNPTLNFKEVTYELDNPSFQIRDSKGLQTVVYGIQRGLGIEAFPVDLVYRPWKNAEGQLSFIQHSLVNPDVFCFADYACHAVATDILKAPPEDDNREIATWKSLDLIESLLRLAELGQYEQVKQLFAYPIKHCPDMLVLALLQINTTWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQARLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVVNKARQPPPGVMPKGRPPSTSSLDAISPVQIDPIAAMASLSIGGSAAPHTQSMPVFPPNLGSAFSTPQSPAKAFPPLTAPNQSTAFSGLGGLTSQLPGGLGTGSLTGMGTGGLSLPTVNSDPFGQRKLSTSGLNQPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNQPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPYQSKMYFFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALSQAQTPAKPASSSAVTTPTTTTPAKTITITRPTGVSFKKDVPPSINTTNIDTLLVATDLAGQIVEPPENVQEKIAFIFNNLSQSNMTQKVEELKETVKDDYMPWVSQYLVMKRVSIELNFHSLYSNFLDALKHLEFNKMVLAETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDLKSLLLEAYVKGQQELLYVVPFVAKVLESSVRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLVLDINDLKPGTLLKDKDRLKSLDEQLSAPKKDVKQPEELPPMTSASEYAIRTAGKLWASVEKQESDAVFTATATAPPPSTTCTTTVPPQPQYSYHDIHVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSIATNLKNSFATAMRAASPQQREMMEQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRPATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLTQPTGFLAQPMKQQAWATDDVAQIYDKCITELEQHLHAIPPALSMNPQSQALRSLLEAVAVARNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVSHVTEAEFFHTIETLMRINAHSRGNAPEGLPQLMDVLRSNFDAMMERAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHEVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSELRSNLQVSNEPGNRYNIQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS
What is the function of this protein?
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs.  Acts as a transcriptional repressor.  Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).
What are the official names of this protein?
CCR4-NOT transcription complex subunit 1, CCR4-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the CNOT1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.