PharMolix/UniProtQA huggingface dataset:
Protein: COX11_MOUSE
Sequence: MGGLWCPGWRLVASCGRGWRQPGWSGRTVVNAELVLRPGWDGLGGAERGLRRLGTWKRPCGVRGPATQPPRRPRSSNPFQRAQEDEWRRRNKTVLTYVAAAAVGMLGASYAAVPLYRLYCQTTGLGGSAVAGHSSDQIENMVPVKDRVIKVTFNADVHASLQWNFRPQQTEIYVVPGETALAFYKAKNPTDKPVIGISTYNVVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYIDPEFAEDPRMVNVDLITLSYTFFEAKEGHKLPVPGYN
What is the function of this protein?
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX11, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX11/CtaG family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Protein: GATY_ECOUT
Sequence: MYVVSTKQMLNNARRGGYAVPAFNIHNLETMQVVVETAASMHAPVIIAGTPGTFTHAGTENLMALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADAFYTNPVQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFSQALKNYLTEYPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: BETB_YERPE
Sequence: MSRYGLQKLYINGAYTDSTSGDTFDAVNPANGECIAQLQAANAQDVDKAVAAAKQGQPVWAAMTAMERSRILRRAVDILRDRNDELAAIETADTGKPLSETRSVDIVTGADVLEYYAGLIPALEGQQIPLRGSAFVYTRREPLGVVAGIGAWNYPLQIALWKSAPALAAGNAMIFKPSEVTSLTALKLAGIYTEAGLPAGVFNVLTGSGDQVGQMLTEHPGIAKVSFTGGIASGKKVMANAAGSTLKDVTMELGGKSPLIIFADADLDKAADIAMMANFYSSGQVCTNGTRVFVPQALQAAFEQKIVERVKRIHIGDPSDERTNFGPLVSFQHRDSVMRYIDSGKREGATLLIGGYSLTEGALAHGAYVAPTVFTHCRDDMQIVREEIFGPVMSILSYQSEEEVIRRANDTEYGLAAGVVTQDLNRAHRVIHQLQAGICWINTWGESAPEMPVGGYKHSGVGRENGISTLEHYTQIKSIQVELGSFNSVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CYSI_SHEON
Sequence: MSEQKLALNEYLKTDSDYLRGTIKEGLDSSVTGSFSDGDQQLIKFHGFYQQDDRDLRNERKEQKLEPLYSFMLRARVPGGVCTPKQWLGVDEIASTLTSSNSIRLTTRQTFQYHGIPKRNLKTIIQGLDREALDSIAACGDVNRNVMCNPNPVESKLHAQAYEVAKKLSDHLLPHTRAYAEIWLDEEKLLTTEDETVEPVYGKTYLPRKFKMAVAVPPDNDVDVYTNDLGFIAVAENGELVGFNLTAGGGMGSTHGEVETFPRLADDFGFIKTEDVMKFAEAVMTVQRDWGNRTNRKRSRLKYTIVDHGYEKFKAEVEVRAGVKFEPKRDVVIGDRGDRYGWVEGVDGKWHLTLFIESGRIKDMPGKSLQTGMREIAKIHKGDFRMTSNQNMIIAGVAPEDKATIEGLARKRGLLGQVLTQTRGHSIACVALPTCPLAMAEAERYFPEFIDHIDALQAKNGISDQAIVVRMTGCPNGCARPFAAEIGLVGKAPGRYNLYLGANFEGTRLNKMYRENIQEAEILAELDALFARYAIERNAGETFGNFTVRVGVVKAVIDAAKDFHG
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: GET3_KOMPG
Sequence: MDIEAEPSLRSIVNHESLKWIFVGGKGGVGKTTTSSSISIQLALHNPNKKYLLISTDPAHNLSDAFNQKFGKDARQVEGLPNLSCMEIDPDSTLENLQKNNESTFGSAGGNDPLKSMMGDITGSIPGIDEAFSFMEVLKHIGETKENQIKYDTVIFDTAPTGHTLRFLQLPSTLEKLLGKVNELSGRFGPMLNNLLGSQGGQSIDFASKIKEIQVQVTEVNKQFQDPELTTFVCVCISEFLSLYETERLIQELMSYNMDVNSIVINQLLFSDDSECRRCNARWRMQKKYLDQMDELYEDYHLVKMPLLAMEVRGLENLKKFSKYLIEPYNSETDGHVVFDLEEQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting.  Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.  Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.
Protein: RSMG_BRUA1
Sequence: MSADIRFDSLKTIVPAVSRETADRLIAFEDLFRKWSKAINLASPSTLADLWNRHILDSAQLFPLAKEATRWLDIGSGGGFPGIVTACFLAERSGGCIDLVESAGKKAAFLRTAAGHLHVPARVHSARIESMWEKIETPQVVTARALASLGDLFTLAEPWLSDGAKALFQKGRDYQREIDESRVGWSFDLVKHPSAIDQASVILEISNLRRKTD
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_SYNC1
Sequence: MKRNGILFVISAPSGAGKTSLCRQIVDIFPDMRHSISFTTRPRRNGETDGVDYHFVTPEVFDTMVAEGAFAEWARVHGNCYGTALATLQEAREQGQDLLLDIDCQGAAQLKRNCPDDVFIFILPPSFEELERRLRGRNTDTAEVIARRLDNARREIRELVWYDYLIVNEDLPRAVEEFKSIILAEGCRASRIRSEAGRLFDIDMQDNSTI
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATL20_ARATH
Sequence: MSGTFLVDEINYQKQQISISDPENCMVKRLLTFNTSGSPFSYGFSFYYTFLTCPNEVVIPVWSLMSIPCLSNSTSSFFATSNLTFSKLLPPSCQIVKGLYVPVDVIYKDVITEEKGFSTVPWLGNVLLEWSSPNCRGCEKESLRCGFKNKASLEVKYLADPPDETKSRLRPLIITLCIIGGITATCIAAIRIYNSERFVNQRRQNAAITARNTTQQPRGVVVTTGLDQSTIESYKKVELGESRRLPGTNGIICPICLSEYASKETVRCMPECDHCFHVQCIDEWLKIHSSCPVCRNSRS
What are the official names of this protein?
RING-H2 finger protein ATL20, RING-type E3 ubiquitin transferase ATL20.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL15_STACT
Sequence: MKLHELYPAEGSRKVRNRVGRGAATGNGKTSGRGQKGQKARSGGKVRPGFEGGQLPLFRRLPKRGFTNINRKEFAVVNLEQLNRFEEGTEVTPELLIETGVVKNAKAGIKVLGNGSLEKKLTVKAHNFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: F16PA_HELAH
Sequence: MDYKHFKGVHANIVIEVISLLEKGVKKAQEILEKPDAGSYTKLENSSGDTPIKADLALDKFLEENFLSLENVKSVFSEEKEKPVTKENGSYLIAYDPLDGSSVMEANFLVGTIIGIYEKDYKAHNLAASLYVVFGHKIELVVALDQVYRYAFYQNKFHFIETIALENKGKIVASGGNQKDFSMGLKKALEGFFTENYRLRYSGSMVADVHHVLIKKGGVFSYPQKKLRKLFEVFPLALIIEKAKGEAFYFDKGVKKRLLDQGVESYHEKSECYLTSQHEAQILEKYLKGE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BACC7
Sequence: MAERTHACGKVTVEAVGQTVQLKGWVQKRRDLGGLIFIDLRDRTGIVQVVFNPETSKEALEVAETIRSEYVLHVEGTVVERGEGAINDNMATGRIEVQATKVNVLNAAKTTPIIIADDTDASEDVRLKYRYLDLRRPVMFNTFKMRHDVTKTIRNFLDTEEFLEVETPILTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMVGGFERYYQVARCFRDEDLRADRQPEFTQIDIEASFLTQEEILDMMERMMTKVMKDAKGVEISAPFPRMTYADAMARYGSDKPDTRFEMELTDLSEFAAGCGFKVFTSAVESGGQVKAINAKGAASKYSRKDIDALTEFVKVYGAKGLAWLKVEEDGLKGPIAKFFGEEDANVLMNTLEATAGDLLLFVADKKSVVADSLGALRLRLGKELELIDESKFNFLWVTDWPLLEYDEDADRYFAAHHPFTMPFREDVELLETAPEKARAQAYDLVLNGYELGGGSLRIYERDVQEKMFKALGFSQEEAQEQFGFLLEAFEYGTPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCLLTEAPSPVAEAQLEELNLKLSLKEEK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLB_GLOVI
Sequence: MKLAYWMYAGPAHIGTLRIATSFKNVHAIMHAPLGDDYFNVMRSMLERERDFTPVTASVVDRKVLGRGSQDKVVTNIVRKDQEEAPDLIVLTPTCTSSILQEDLQNFVARAQEQSKADVLLADVNHYRYNEFTAADRTLTQIVSYYIEKLAGNLPARSEKPTANILGISTLGFHNHHDCRELKQLLADLGVEVNVVAPEGCSVHDIQKMPSAWFNVVPYRELGRGAAEYLQRQTGQPLIDITPMGILQTARFIRAVQQILNTQGARVEYEEYIRSQTLFVSQAAWFSRSIDCQNLQGKRAVVYGDLTHAAAMTRILAREMGVRVVWAGTFCKYDAEWFKAEVADLCDEVLISDDHAEVGDRIAAAEPAAIFGTQMERHIGKRLNIPCGVISSPIHIQNFPVGYRPFLGYEGTNQIADLVYNSFTLGMEDHLLEVFGGHDTKEVITKTMTAQSDLEWDEAATRELAKIPGFVRSKVKRNTEKFARESGRDKITLEVMYAAKEAAGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: MSRP_ACTPJ
Sequence: MNRFTRYDVTPEVIFNQRRQIIKAMGLGAAALSLPNIGFAAEKSDQLKALNFKDAPKGDFLLTPENKVTGYNNFYEFGVDKASPAKFAKDFKTDPWSLEIAGEVENPFVLNHAQLFNTFPLEERIYRFRCVEAWSMVIPWVGFELARLVEMAKPTSKAKFVIFHTLHDPEQMPGQKNKFFGGGIDYPYVEALTIEEAMNPLTLLSVGLYGKMLPPQNGAPIRLVVPWKYGFKSIKSIVKITFSETRPRTTWEKLAPHEYGFYANVNPNVDHPRWSQASERVIGSGGLLAVKRQDTLMFNGYEKEVAHLYKGLDLKVNF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: UGPE_ECOL6
Sequence: MIENRPWLTIFSHTMLILGIAVILFPLYVAFVAATLDKQEVYAAPMTLIPGTHLLENIHNIWVNGVGTNSAPFWRMLLNSFVMAFSITLGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFFMTLPDELVEAARIDGASPMRFFCDIVFPLSKTNLAALFVITFIYGWNQYLWPLLIITDVDLGTTVAGIKGMIATGEGTTEWNSVMAAMLLTLIPPVVIVLVMQRAFVRGLVDSEK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpE.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TCAL9_HUMAN
Sequence: MKSCQKMEGKPENESEPKHEEEPKPEEKPEEEEKLEEEAKAKGTFRERLIQSLQEFKEDIHNRHLSNEDMFREVDEIDEIRRVRNKLIVMRWKVNRNHPYPYLM
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Transcription elongation factor A protein-like 9, TCEA-like protein 9, Transcription elongation factor S-II protein-like 9, WW domain-binding protein 5, WBP-5.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3769_VIBCH
Sequence: MTKDREIRQTVPAQPTSDGDGVKIQRIAGFQRPNFSPFLMLDELKADSQADYIGGFPPHPHRGIETLTYMLQGHFQHRDQMGNVGELRSGGAQWMAAGHGVIHSEMPIMQEGQLHGFQIWINQPARNKMSPAKYQDFQPESIVERHHPQQGLLRVIAGSVEVEDQTITGPLTDTGVPATVVDWRAEAGQDISINTPPHFNAMLYVYRGSLNVGKQSVKTGHMAMLTAGEQLTLRAEQPCGSLLLMGQPIDEPVVHYGPFVMNSMAEIEQAIRDYNAGHFETY
What is the function of this protein?
Putative quercetin 2,3-dioxygenase.
What are the official names of this protein?
Putative quercetin 2,3-dioxygenase VC_A0969, Putative quercetinase, Pirin-like protein VC_A0969.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: ALLC2_BURMA
Sequence: MAAPILDPNAPAFTRRYMNLADPRLGAKALFASDEFFAPKERMLDPEPAVFIPGKYDDHGKWMDGWETRRKRTTGHDFCVVRLARPGVVYGVDLDTSHFTGNFPPAASIDACVSDADTPPDDAVWETLVPATTLAGNQHHYVDVSNPRAYTHLRVNLYPDGGLARLRVYGQPQRDWSRAARGELVDLAAIENGAYLVAANNEHFGPASRMLMPGRGANMGDGWETRRRREPGNDWAIVALARPGVIRRVEVDTAHFKGNFPDRCSLQAARVAGGTDASLVTQAMFWPMLLGEQPLGMDSVHTFETQLAALGPVTHVRLNIHPDGGVSRLRFWGELA
What are the official names of this protein?
Probable allantoicase 2, Allantoate amidinohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: GBRA3_RAT
Sequence: MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLAKDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
What is the function of this protein?
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: ATPA_STRPI
Sequence: MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGLENAMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGESLIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGALDYTIVVTASASQPSPLLFLAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNVISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYRELEAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPVDDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SCP13_ARATH
Sequence: MSLTLEFLLLLIVLILSHHAHSGSIVKFLPGFEGPLPFELETGYIGIGEEEEVQLFYYFIKSEKNPEEDPLLLWLSGGPGCSSLTGLLFENGPVALKFEVYNGSVPSLVSTTYSWTKMANIIFLDQPVGSGFSYSRTPLVDKISDTGEVKRIYEFLQKWLSKHQQFFSNPFYVGGDSYSGMIVPPLVQEIGKGNYQINLQGYILGNPITDTESEQNYQIPYAHGMALISDELYKSMERICKGNYVKVDSLNTKCYKLIKDYQKCIHKLNKYHILLPDCDITSPDCFLYRYTLITFWANNKSVREALQVNKGSIGKWVQCNYKNISYNYDIKSSVAYHMKNSIDGYRSLIYNGDHDMMVPFLATQAWIRSLNYSITDDWKPWMINDQIAGYTRSYSNKMTFATIKGSGHTAEYKPKETSIMFKRWISAQPL
What is the function of this protein?
Catalyzes the formation of 1,2-bis-O-sinapoyl beta-D-glucoside.
What are the official names of this protein?
Serine carboxypeptidase-like 13, Sinapoylglucose--sinapoylglucose O-sinapoyltransferase, Sinapoylglucose--sinapoylglucose acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IRF7_MOUSE
Sequence: MAEVRGVQRVLFGDWLLGEVSSGQYEGLQWLNEARTVFRVPWKHFGRRDLDEEDAQIFKAWAVARGRWPPSGVNLPPPEAEAAERRERRGWKTNFRCALHSTGRFILRQDNSGDPVDPHKVYELSRELGSTVGPATENREEVSLSNALPTQGVSPGSFLARENAGLQTPSPLLSSDAGDLLLQVLQYSHILESESGADPVPPQAPGQEQDRVYEEPYAAWQVEAVPSPRPQQPALTERSLGFLDVTIMYKGRTVLQAVVGHPRCVFLYSPMAPAVRTSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEVGSPMGTTGPSTPPQLLERNRHTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDLSAGRPKEKTLILVKLEPWVCKAYLEGVQREGVSSLDSSSLGLCLSSTNSLYEDIEHFLMDLGQWP
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:27129230, PubMed:22095711).  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.  Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.  Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (PubMed:27129230).  Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase.  Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases.  This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes.  Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1.  Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency.  Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
What are the official names of this protein?
Interferon regulatory factor 7, IRF-7.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Protein: UGA4_YEAST
Sequence: MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQLLAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFILLVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAEEIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVLLFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQSEEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSLGKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAILAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGKIWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKYYHGPATNLSDDDYTEAVGADVIDTIMSKQEP
What is the function of this protein?
Required for high-affinity, high-specificity GABA transport.  Also transports putrescine.
What are the official names of this protein?
GABA-specific permease, GABA-specific transport protein.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
Protein: BRD2_HUMAN
Sequence: MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
What is the function of this protein?
May play a role in spermatogenesis or folliculogenesis (By similarity).  Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling.  Regulates transcription of the CCND1 gene.  Plays a role in nucleosome assembly.
What are the official names of this protein?
Bromodomain-containing protein 2, O27.1.1, Really interesting new gene 3 protein.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin and nucleosomes.
Protein: Y4878_SERP5
Sequence: MSFFRRKKLPSAIKPGVTFGRLLIKRVDSDGLTMLAGHLAYVSLLSLVPLVTVVFALFAAFPMFSDISVQLKSFIFSNFMPAAGNVIQSYLEQFVANSNKMTAVGTCGLIVTALLLISSVDSVLNTIWRSKNKRPIVFSFAVYWMVLTLGPLLVGASMAISSYLLSLNWLAQSGVNSLVDQVLRIFPLILSWISFWLLYCIVPTVRVPPKDALIGALVAGVLFELGKKGFALYITMFPSYQLIYGVLAVIPILFLWVYWSWCIVLLGAEITVTIGEYRDYRQQKAEQQAQPPEGQL
What are the official names of this protein?
UPF0761 membrane protein Spro_4878.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTB_SPHGR
Sequence: PGPDVKCVCCQDGEECPCKGGECCITGTCCKEGDGLCCGKCSNAACKCADGCKCGSGCSCTLGNCTC
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-B, MTB.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 4 family.