PharMolix/UniProtQA huggingface dataset:
Protein: RLMG_YERPN
Sequence: MSQLDLGTQSLELERFPPQENSNTLQAWEAADEYLLQNIDLSQIDGRPVLVFNDQFGTLACALHAYRPFSSSDSYMSQLATAHNLRLNHLDESAVTLLSSVDDLPEAPKLVVIKIPKALALLEHQLRALRRVVAPDTVIIAGAKSRDVHNSTLQLFEKILGPTKTTLAWKKARLIHCEVADIPLADAPETIDWPLPNTDYIIHNHANVFSRNNLDIGARFFMEILPYDVTGKIADLGCGNGVVGLIALEQNPLAEMLFVDESYMAVASSELNITVNRPQDLSRCEFMVSHGLAGVERESLQLVLCNPPFHQQHAVSDHVAWQMFCDAKRCLKAGGELMIVGNRHLDYFHKLKRLFGNCETLDSNQKFMVLKSVKQASSRSEGGGSGSLDMSYSDF
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_THEYD
Sequence: MIALLQRVNKASVEVGGETISEIGKGILIFLGIDKKDSKKDVEYLADKVVNLRIFEDNNSKMNLSIKDVGGEIMVVSEFTLAGDCKKGNRPSFDKAMPPEEAEKLYRDFIDSLRSKGIPVKEGVFRSFMHVSLINEGPVTFILNTR
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_THEVB
Sequence: MQVSEMKYGERAIQEGQLITFPNPRPGRQYTIEITLPEFTCKCPFSGYPDFATLYVSYIPHEKVVELKAIKLYINSYRDRYISHEEAVNQVLDDLVAACDPLYMKIKGDFAPRGNVHTVITVEHHRQTESLC
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BACFN
Sequence: MGQKVNPISNRLGIIRGWDSNWYGGNDYGDSLLEDSKIRKYLNARLAKASVSRIVIERTLKLVTITVCTARPGIIIGKGGQEVDKLKEELKKVTDKDIQINIFEVKRPELDAVIVANNIARQVEGKIAYRRAIKMAIANTMRMGAEGIKIQISGRLNGAEMARSEMYKEGRTPLHTFRADIDYCHAEALTKVGLLGIKVWICRGEVFGKRELAPNFTQSKESGRGNNGGNNGGGKNFKRKKNNR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: LGT_VEREI
Sequence: MLIYPPIDPVALQIGPLAIHWYGLSYLAAFGLFMLLGCRRLRHPPFAGRTGPGAWSRKDVEDILFLGVAGVVLGGRLGYCLFYKPDYYLGHPLEVFALWQGGMAFHGGLLGVIVAMLWFAHSRQRPLLQVADFVAPCVPTGLAAGRVGNFINGELWGRFASPDLPWGMVFAHSGSMQPRHPSQVYQFLLEGLLLFVLLWLYARRERRQGQVAAAFLVGYGVLRFIAEQFREPDAFLGILALGMSMGQWLCLPMIAGGVLLWCRAARRRPAVARGSRA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOB3A_MOUSE
Sequence: MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNAGLDLRLAVQLPPGEDLNDWVAVHVVDFFNRINLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEQRFRKPTALSAPRYMDLLMDWIEVQINNEDIFPTNVGTPFPKTFLQAVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVTEFNLIDPKELEPLKEMTSRMCH
What is the function of this protein?
May regulate the activity of kinases.
What are the official names of this protein?
MOB kinase activator 3A, Mob1 homolog 2A, Mps one binder kinase activator-like 2A.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: 4CLL4_ORYSJ
Sequence: MGRSPEMEVDARSGYCAATRTFRSRRADVPLPADPEVDVVSFLASRRHSGVVALVDAATGRRITFTELWRAVAGAASALAAHPVSLRKGHVALILSPNSVHFPVAALAAMSLGAVLTTANPLNTPAEIAKQVADARPVLAFTTRELLPKLPRAHDLRVVLLESARLPGDSSDPRIVATIEEISATTPDPARRKDRVTQDDPATLLYSSGTTGPSKGVVATHRSLISMVQIIMTRFRLEGSDKTETFLCTVPMFHVYGLVAFATGLLGCGATVVVLSKYELPEMLRSINAYGVTYLPLVPPILVAMVAHPKPLPLGQMRKVLSGGAPLGKELIEGFREKYPQVEILQGYGLTESTAIGASTDSAEESRRYGTAGLLSPNTEAKIVDPDSGEALPVNRTGELWIRGPYVMKGYFKNAEATQSTLTPDGWLKTGDLCYIDEDGYLFVVDRLKELIKYKGYQVPPAELEALLLTHPEVTDVAVIPFPDREVGQFPMAYIVRKKGSNLSEREVMEFVAKQVAPYKKVRKVAFVTDIPKNASGKILRKDLIKLATSKL
What is the function of this protein?
Carboxylate--CoA ligase that may use 4-coumarate as substrate.  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
What are the official names of this protein?
4-coumarate--CoA ligase-like 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: DDL_SYNP2
Sequence: MARQRVGLLFGGKSGEHDVSIVSAAAIAKAFAQEDNPDKYELLPFYIDRNGIWHDPEISQQVLTAGKALPVETVDPASRWQFPPAAPSIDAWFPIVHGPNGEDGTLQGLLTLMEKPFVGSKVLGSAAGMDKLAMKMVFAQAGLAQVDYVGVLRSEVWSGPCVFPKVCDKIEAQLDYPMFVKPANLGSSVGISKVRTRDELEKALDLAAEYDRRLIVEAGVTAREVECAVLGNDQPKASVVGEIRFDSDFYDYETKYTDGKSSMHIPAEIPGAIAQQIQELAIKAFQALDCRGIARVDFFYVEATQTVLINEINTLPGFTALSMYPQLWQQSGVPFPQLVDRLVQFALEDVPQA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_SALA4
Sequence: MKVAVLGAAGGIGQALALLLKNQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQIAKTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKLPTEVEVPVIGGHSGVTILPLLSQIPGVSFTEQEAAELTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQHSLDAMLDTLKKDIQLGEDFINK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: CB072_HUMAN
Sequence: MERELEALAARLARPAEPPFQALVEAAGGRGQVLLVGELWEREQSRALLRDFARAVFPPEPGAAKPGGAAAEGAGPGAARGAQRAARAAGAAGAAAAAARAIRSPLVFVLCRASSLAAREPRRRLREMLRDVRGRRRAGAALVGVLVAEAGPEDAVAPGLRLLEALLRAVFGRQAGGPVQAAAYCPGLPASCLAVQAAACRALQAAGAGQPVEGAWERPGLPGLLACFSWGPWSRRKNQDVAACRSSAQEDFQEPEEELPLTAIFPNGDCDDLGRGSKACDGVVHTPAEPTGDSR
What are the official names of this protein?
Uncharacterized protein C2orf72.
Protein: SYFB_PROMT
Sequence: MKVSVSWLKDLVEFNNDIDELSEKLSMTGFEVESLEDLSEQAKNVVIGFVEEITPHPNAEKLKVCSVDVGLPKKLSIVCGAPNVKAGFHVLVAKVGAYLSSKSLKIKLSNLRGVESEGMICSLEELGIESSNEGIEILEENEANIPPIGSNAVDYLCLNDTIIELAITANRPDGMSMVGIAREISTITNSKLTLPNLNYIEDFNIFEPKICDKETIGVDCIYSITYIDSIDNTGKTNKNIFNKLSSLKQNCINPVVDITNYLMLEQGQPLHAFDADLLDNIIGRKVKPNDFGIRNGKQGELFVALDKKEYKINPTIKLITCDDIPIAIAGVIGGNNSSVSDKTTRIWLEAAVFTPTSIRNSSREIGLRTDASSRYEKGISSNMTTAVSKRASELISVQLGGDNISSYVNTDFKKKSISVNLRMDKINSVLGKLSSSDSNFVNNNSTKLRYLNEDEIETLLSKLGLILTSNDSGWNVQVPPYRSSDLTREIDLIEEIARLIGYDNFDSNMPDPLEPGVLSPTKLVERRLRNSFIHNGFQEVVTSSLVGPENTDDNAVLIKNPLLSETSRLRTNVWDEHLKILQRNVSFGAEGCWIFEIAKTYKKDKECFVETNLLSGALTGSKRLSKWGGASKQLSLDYFEARGKLKQSLDVLGVETIDKQLAEKDFMHPGRTSELFVEGKSIGFFGQIHPSQSEKFDLIKETYLFNLDFDSLIKAATRKTNWTRIYKDYPTVPYMERDIALIHSKKYSSLEIMGLIKKTGRPLLEKVELIDRYEGSSMPEDEISQAFRIRYRDAKKTLVEKDINPIHEKIRNALKEKIKAELRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_METST
Sequence: MVKITIMGASGTIGKTVAFNLAEKDVIDEIIMFSRPASHERVKGEILDMYDALAAEDIDCELKASSDYADLAGSSIVLITSGVPRKEGMSRLDLAVPNSKIVQEYSKQIAIHAPDSVILIVTNPVDVMTSIALKTSGFDKKRVIGLGNHLDSLRLKTLLSKHFHINSREIHTRVIGEHGDHMVPLLSSTTIGGILLKSFVEYMDLDVPKLVETLKNSGNNIISKKGATEYGPSYAISNLILTIANDTRKILTVSTYLEGEVEGVYDVSLGVPVILCKHGIKRIVPLKMNDEERTEFFDAARTVKKTTYELEKMLNKE
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily.
Protein: PUR7_SHEDO
Sequence: MSLADSVLAVNNDLPIRTDKPVHSGKVRSVYWLTESDSRRLINDKGYKVPLDTPLAIMVISDRISAFDCIFHGEGGLQGIPGKGAALNAISNHWFKLFAEQGLADSHILDIPHPFVWIVQKARPIKVEAICRQYITGSMWRAYAKGEREFCGIRLPEGLKKDQKLPELIITPSTKGILTGIPGVPAQDDVNISRQDIEANYQAFGFESLSDIDLYETLLKDGFKVISDALAQLDQVFVDTKFEFGYVTDKNGQSKLIYMDEVGTPDSSRIWDGAAYRDSKIVENSKEGFRQFLLNHVADADVLLNKDRMPEREALARDNALPLDAMMNVSRTYTGVAEKVTGKTITLAANPKADIIAILKKNYGLID
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DPO3B_AQUAE
Sequence: MRVKVDREELEEVLKKARESTEKKAALPILANFLLSAKEENLIVRATDLENYLVVSVKGEVEEEGEVCVHSQKLYDIVKNLNSAYVYLHTEGEKLVITGGKSTYKLPTAPAEDFPEFPEIVEGGETLSGNLLVNGIEKVEYAIAKEEANIALQGMYLRGYEDRIHFVGSDGHRLALYEPLGEFSKELLIPRKSLKVLKKLITGIEDVNIEKSEDESFAYFSTPEWKLAVRLLEGEFPDYMSVIPEEFSAEVLFETEEVLKVLKRLKALSEGKVFPVKITLSENLAIFEFADPEFGEAREEIEVEYTGEPFEIGFNGKYLMEALDAYDSERVWFKFTTPDTATLLEAEDYEKEPYKCIIMPMRV
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_BURVG
Sequence: MSMSDPIADMLTRIRNAQMVEKVSVAMPSSKVKVAIAQVLKDEGYIDDFAVKAEGAKSELNIALKYYAGRPVIERLERVSKPGLRVYRGRNDIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RK20_AETCO
Sequence: MTRIKRGYIARRRRTKIRLFASSFRGAHSRLTRTMTQQRIRALVSAHRDRGRRKRDFRRLWITRINAVIQEMEVFNSYNRFIHNLYKKQLLLNRKILAQIALLNRSCLYTISNEIIK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PHP14_BOVIN
Sequence: MAAAGLAQIPDVDIDSDGVFKYVLIRVYAAPPSGDPAVETKEIVRGYKWAEYHADIYDKVSGEIQKKGYDCECLGGGRISHQSQDRKIHVYGYSMGYGRAQHSVSTEKIKAKYPDYEVTWADDGY
What is the function of this protein?
Exhibits phosphohistidine phosphatase activity.
What are the official names of this protein?
14 kDa phosphohistidine phosphatase, Phosphohistidine phosphatase 1, PHPT1, Protein histidine phosphatase, PHP.
What is the protein family that this protein belongs to?
Belongs to the janus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB2_I57A3
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPMTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMIGVLPDMTPSTEMSMRGLRVSKMGVDEYSRAERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLTEDPDEGTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: RS20_CORA7
Sequence: MANIKSKQKRILTNEKSRQRNKSVRSAVRTEIRKFREAVAAGDKAAAEKQLRVASRALDKSVSKGVFHRNTAANKKSGMATAFNKMA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: FLGI2_BRADU
Sequence: MTRLLLALILVVSAASAQAAVRIKDIADIKGLRENQIVGYGLVIGLNGTGDTLRNAPFTEQSLQSMLENMGINVRNETTSTTNPARPTTLRTRNVAAVMVTADLQPSIGAGERMDVTVSSLGDATSLLGGTLVMTSLRAADGAVYAVAQGAVTVAGYSVGGQAQNVSQGTPTAGRILNGALVEREVQGSLHEMEFLVLELKNPDFVTATRILDAINRYAGGRYRAQIAFERDYRTIVLSKPRHIGPVRFLAEIGELTVEPDTPARVVINERTGTVVIGRDVRISTVAVTHGNLTVRVTEMPVVSQPAPFSRGQTVVVPQTVVEANEAGSQVAILSGVDLQRLVRGLNQIGLKPSGIIAILQAIKTAGALQADVIVQ
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 2, Basal body P-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: SLS11_TRYCC
Sequence: MVLMGPHSALRLLPLKTQAIRFVLLLLLSVLILAVALLVTNARMPDPKVVRPLPDIGFEVFPKVGWLEHLTDVCIFILNFLSLLVVFKLYLLHRQNEGLDELQPFSCCPLIGKIIFGVWDSGRQSGIEKRDAHLIAWIRYFTTYFIVLLFRAIVVVMTSYPATDNHCQNPMKITNPVKNVIMTLVTFGSGSIHCGDLMFSGHTVSITLSLLVQWIYGSMLHWVFRPASVLLVLLSFYSIIASRSHYTDDILVSFYITVTTFLVLRHSPDGAPWQLQLLIGWWPCCVSNEETEDSDRNPTFVAVEVFLPHGDYQCAERISEEKTTVGPACGNFGHW
What is the function of this protein?
Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa.  Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors.  Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target.
What are the official names of this protein?
Phosphatidylinositol:ceramide inositolphosphotransferase, TcSLS1.1, Inositol-phosphorylceramide synthase, IPC synthase, Sphingolipid synthase.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PTKA_MYCTU
Sequence: MSSPRERRPASQAPRLSRRPPAHQTSRSSPDTTAPTGSGLSNRFVNDNGIVTDTTASGTNCPPPPRAAARRASSPGESPQLVIFDLDGTLTDSARGIVSSFRHALNHIGAPVPEGDLATHIVGPPMHETLRAMGLGESAEEAIVAYRADYSARGWAMNSLFDGIGPLLADLRTAGVRLAVATSKAEPTARRILRHFGIEQHFEVIAGASTDGSRGSKVDVLAHALAQLRPLPERLVMVGDRSHDVDGAAAHGIDTVVVGWGYGRADFIDKTSTTVVTHAATIDELREALGV
What is the function of this protein?
Required for growth within macrophages (PubMed:29317718).  Catalyzes the phosphorylation of PtpA on the tyrosine residues at positions 128 and 129, thereby increasing PtpA phosphatase activity and promoting pathogenicity (PubMed:19366344, PubMed:22888002, PubMed:25535696, PubMed:29724125).  Also phosphorylates the thioredoxin reductase TrxB (PubMed:29317718).
What are the official names of this protein?
Tyrosine-protein kinase PtkA, Protein tyrosine kinase A.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: HEMA_I57A4
Sequence: MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPG
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: ADH_DROIN
Sequence: MALTNKNIIFVAGLGGIGLDTSRELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTTPLTETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNFTGLVNTTTAILDFWDKRKGGPGGVICNIGSVTGFNAIYQVPVYSASKAAVVSFTQSIAKLANVTGVTAFTVNPGITKTTLVHKFNSWLDVETRVAEKLLEHPTQTTLACAQNFVKAIELNKNGAIWKLDLGTLEPIEWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HBSAG_HBVD2
Sequence: MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDSWPDANKVGAGAFGLGFTPPHGGLLGWSPQAQGILQTLPANPPPASTNRQSGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYLPAGGSSSGTVNPVPTTVSPISSIFSRIGDPALNMENITSGFLGPLLVLQAGFFLLTKILTIPKSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCTTPAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLLVIWMMWYWGPKLFTILSPFLPLLPIFFCLWVYI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: LTUB_CHLPN
Sequence: MGKPKKSRTDRALAQEIQKKSTEVLKKPARIKAKNRRKFLIAKEQKTLKHRAQEYDQLVRSLLDSQKKDTDKVLIFNYENGFVFTDKDHFSKYSIRL
What are the official names of this protein?
Late transcription unit B protein.
Protein: IBP5_PIG
Sequence: MVLTAVLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVILAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHSFDSSNVE
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5.
What are the subcellular locations of this protein?
Secreted.
Protein: NRDR_STRMU
Sequence: MRCPKCNYLKSSVVDSRQAEEGNTIRRRRECENCHTRFTTFERIEELPLLVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSSAIEKVVNDIEQKIRSDYDSEVSSVVIGNLVMDELAELDEITYVRFASVYRSFKDVDEIEALLQQITNRVRSKKKRKADETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: LAMB_ECO5E
Sequence: MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQTTGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAGGSSSFASNNIYDYTNETANDVFDVRLAQMEVNPGGTLELGVDYGRANLRDNYRLVDGASKDGWLFTAEHTQSVLKGFNKFVVQYATDSMTSQGKGLSQGSGVAFDNEKFAYNINNNGHMLRILDHGAISMGDNWDMMYVGMYQDINWDNDNGTKWWTVGIRPMYKWTPIMSTVMEIGYDNVESQRTGDKNNQYKITLAQQWQAGDSIWSRPAIRVFATYAKWDEKWGYDYNGDSKVNPNYGKAVPADFNGGSFGRGDSDEWTFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.