PharMolix/UniProtQA huggingface dataset:
Protein: JPH2_HUMAN
Sequence: MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT
What is the function of this protein?
Transcription repressor required to safeguard against the deleterious effects of cardiac stress.  Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes.  Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis.  Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress.  Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.
What are the official names of this protein?
Junctophilin-2, JP-2, Junctophilin type 2.
What is the protein family that this protein belongs to?
Belongs to the junctophilin family.
What are the subcellular locations of this protein?
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus. Note=Accumulates in the nucleus of stressed hearts.
Protein: DEOC_LACLS
Sequence: MQINKYIDHTILKADAPKSKVQQIIDEAKKYDFMSVCINPTWVNYASQELKDSDVKVCTVIGFPLGANTSELKAFEAKNAIENGADEIDMVINIGAAKSKDWDLVESDIADVNAVKGDKLLKVIIETSLLTDEEKIKACQIAKAVGADFVKTSTGFSTGGAAVHDVKLMRQTVGPDMGVKASGGVHNLEEAKAMIDAGATRLGVSAGVAIMEGLTSNDSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKAP5_RAT
Sequence: METSVSEIQIETKDEKRPEAASPQKERQERKTATLCFKRRKKVNKKKAKAGSKTAEETEKHAPEAGGSGQRQPAGAWASIKRLVTHRKPSESAEKQKPSEAEMQPEDGALPKKKTKSKLKIPCIRFSRGAKRSRPSKLTEDSGYVRVQGEADDLEIKAQIQPDEQATQAKSTQGLQEDVIVRDGKEIQESHISNNVISGEHVIGIELELEKESSALRMRTPGSEKEAKVILVKQGVQVQEASVLENSAADSPQPVTSTAPLSPATTHQLGLEEPSDSIRESAPSGKDDGRRKTAAEEKKSGETALGQAEEASSVSQADKSVLSQAEEATVGHTEEATVIQAQSQAKEGKLSQAEEATVAQAKETVLSQAEEVKLSQIEEPAISQAKKATVGQAKEAYVSQAEEAIVGHTEKATMGQAEEATVGHIEKTTVGQAEEATVGQAEEATVGQAEEATVGQAEEATVGQAEEATVGQAGEATVSHIEKTTVGQAEEAIVGQAEEATVGQAEEATVGQAEEATVGQAEEATVDQAEEATVGQAEEATVGQAGEAAVGQAEEAIVAQAEEATVGQAGEATVGQAEKATVGQAEEPIVGQAEETVLRHASDLKVNGVDAEKPRSEESKRMEPIAIIITDTEISEFDVKKSKNVPKQFLISMENEQVGVFANDSDFEGRTSEQYETLLIETASSLVKNAIELSVEQLVNEMVSEDNQINTLFQ
What is the function of this protein?
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors.  Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.  Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses.
What are the official names of this protein?
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 150 kDa, AKAP 150, P150, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein.
What are the subcellular locations of this protein?
Postsynaptic recycling endosome membrane; Lipid-anchor. Note=Associates with lipid rafts.
Protein: RF3_XANCB
Sequence: MSEVSNEAARRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKGRKAARHATSDWMALEKERGISVTSSVMQFPYEDKIVNLLDTPGHADFGEDTYRVLTAVDSALMVIDVAKGVEERTIKLMEVCRLRDTPIMTFINKLDREGKNPIDLLDEVETVLGIQCAPVTWPIGMGQRLKGVVHLITGEVHLYEQGRNFTRQDSTIFPSLDAPGLAEKIGTQMLDELREELELVQGASNPFDLDAYRAGQQTPVFFGSGVNNFGVQPLLDFFVEHAPPPQARDTTGRRVEAVEPKLSGFVFKIQANMDPQHRDRVAFMRVCSGKFTAGMKALHVRSGKDVKLANALTFMASDREIAAEAWPGDVIGIHNHGTISIGDTFTEGESLSFTGIPNFAPELFRRARLRDPLKLKQLQKGLAQLSEEGATQFFRPLMSNDLILGAVGVLQFDVVAYRLKDEYGVDAIFEPVSVTTARWVHCDNPKKLEEFREKNAGNLGIDAAGQLVYLAPTRVNLQLAQERAPDVRFSATREHAYATAVD
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLY3_BACCE
Sequence: MTEKMTRMTQFVKEEIANAITHGIGAILSIPALIILIIHASKHGTASAVVAFTVYGVSMFLLYLFSTLLHSIHHPKVEKLFTILDHSAIYLLIAGTYTPFLLITLRGPLGWTLLAIIWTLAIGGIIFKIFFVRRFIKASTLCYIIMGWLIIVAIKPLYENLTGHGFSLLLAGGILYSVGAIFFLWEKLPFNHAIWHLFVLGGSAMMFFCVLFYVLPTAS
What are the official names of this protein?
Hemolysin-3, Hemolysin III, Hly-III.
What is the protein family that this protein belongs to?
Belongs to the UPF0073 (Hly-III) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFG_PROMP
Sequence: MARDFPLERVRNIGIAAHIDAGKTTTTERILFYSGVVHKIGEVHDGAAVTDWMAQERERGITITAAAISTSWQDHRINIIDTPGHVDFTIEVERSMRVLDGVIAVFCAVGGVQPQSETVWRQADRYSVPRMVFVNKMDRTGADFLKVNQQIKDRLKANAFPIQLPIGAEGDLSGIIDLVSNKAYLYKNDLGTDIEEAPIPDEMKDEALEWRSKLMESVAENDEELIEIFLDKGELTEDQLKKGIREGVLKHGLVPVLCGSAFKNKGVQLVLDAVVDYLPAPIDVKPIQGVLPNGKEDVRPSDDNAPFSALAFKVMSDPYGKLTFVRMYSGVLSKGSYVMNSTKDAKERISRLVILKADEREEVDELRAGDLGAVLGLKNTTTGDTLCNTDDPIVLETLFIPEPVISVAVEPKTKGDMEKLSKALQALSEEDPTFRVSTDQETNQTVIAGMGELHLEILVDRMLREFKVEANIGAPQVSYRETIRSSSKGEGKYARQTGGKGQYGHVVIEMEPAEVGKGFEFVNKIVGGTVPKEYIGPASNGMKETCESGVLAGYPLIDVKVTLVDGSFHDVDSSEMAFKIAGSMAFKDGVKKCNPVLLEPMMKVEVESPDDFLGSVIGDLSSRRGQVEGQSVDDGLSKVQAKVPLAEMFGYATQLRSMTQGRGIFSMEFANYEEVPRNVAEAIISKNQGNS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_BORDL
Sequence: MARSKSQKIEGCSFCGRTRAEAEGKIISAKSVAICFECSKICHNLFKEESDKPASNKAPRGLPTPKQLKSHLDKYIIGQEDAKKVLSVAVYNHYKRIFKGSKRETGVELEKSNVLLVGPTGSGKTLLAKKLAAEMNVPFAIADATTLTEAGYVGEDVENILLKLIHAANGDVSFAERGIIYIDEIDKIAKKGENVSITRDVSGEGVQQSLLKIIEGTIANVPPRGGRKHPYEETIAINTHDILFICGGAFVGLENIIKKRINRSFIGFSSSSCKDTGGDNSLKYLEMEDLIKFGLIPEFVGRLPVHSYLDKLEKKDLMKILVEPENSIVRQYYHMFKMDNVDLLFEKDALDAIAEEAMLKNTGARGLRSILEELLKDVMFEIPSSKQIKKVIVTKDSVLNTNVEPLILTGRHVNKPWAKELYEINSKSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: AA1R_PONAB
Sequence: MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVLLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLTIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDNFRCQPAPPIDEDLPEERPDD
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity).
What are the official names of this protein?
Adenosine receptor A1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNH2_PYRFU
Sequence: MKIGGIDEAGRGPAIGPLVVATVVVDEKNIEKLRNIGVKDSKQLTPHERKNLFSQITSIADDYKIVIVSPEEIDNRSGTMNELEVEKFALALNSLQIKPALIYADAADVDANRFASLIERRLNYKAKIIAEHKADAKYPVVSAASILAKVVRDEEIEKLKKQYGDFGSGYPSDPKTKKWLEEYYKKHNSFPPIVRRTWETVRKIEESIKAKKSQLTLDKFFKKP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCCS_ECOLI
Sequence: MLSPLLKRYTWNSAWLYYARIFIALCGTTAFPWWLGDVKLTIPLTLGMVAAALTDLDDRLAGRLRNLIITLFCFFIASASVELLFPWPWLFAIGLTLSTSGFILLGGLGQRYATIAFGALLIAIYTMLGTSLYEHWYQQPMYLLAGAVWYNVLTLIGHLLFPVRPLQDNLARCYEQLARYLELKSRMFDPDIEDQSQAPLYDLALANGLLMATLNQTKLSLLTRLRGDRGQRGTRRTLHYYFVAQDIHERASSSHIQYQTLREHFRHSDVLFRFQRLMSMQGQACQQLSRCILLRQPYQHDPHFERAFTHIDAALERMRDNGAPADLLKTLGFLLNNLRAIDAQLATIESEQAQALPHNNDENELADDSPHGLSDIWLRLSRHFTPESALFRHAVRMSLVLCFGYAIIQITGMHHGYWILLTSLFVCQPNYNATRHRLKLRIIGTLVGIAIGIPVLWFVPSLEGQLVLLVITGVLFFAFRNVQYAHATMFITLLVLLCFNLLGEGFEVALPRVIDTLIGCAIAWAAVSYIWPDWQFRNLPRMLERATEANCRYLDAILEQYHQGRDNRLAYRIARRDAHNRDAELASVVSNMSSEPNVTPQIREAAFRLLCLNHTFTSYISALGAHREQLTNPEILAFLDDAVCYVDDALHHQPADEERVNEALASLKQRMQQLEPRADSKEPLVVQQVGLLIALLPEIGRLQRQITQVPQETPVSA
What are the official names of this protein?
Inner membrane protein YccS.
What is the protein family that this protein belongs to?
Belongs to the YccS/YhfK family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_CAMJR
Sequence: MTRSEKVEIIAKLEEGFKASEAIVVCNYRGLSTKKLEELRNNARENNVKVQIVKNTLANIALNNSGKTGLVLKDTNIYLWGEDQLGVSKVAAKFEENNDKFEIKTAHIEGEVADVAKVKALAKMPSRNELLAMLLQVWNAPITNFTIGLNALKNKKESE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TPM_ECHMU
Sequence: MDSIKKKMMAMKLEKENALEKAINLENQLKEKAKDFEKKEEEMNDWLSKVKNIQTEVDTVQESLQEAISKLEETEKRATNAEAEVAAMTRRIRLLEEDFEQSSGRLTETSTKLDDASKAAEESERNRKTLETRSISDDERMAQLEEQVKEAKYIAEDAERKYDEAARRLAVTEVDLERAESRLETSESKIVELEEELRIVGNNMKSLEVSEQESLQREESYEETIRDLTERLKTAEQRAAEAERQVSKLQNEVDRLEDELLSEKERYRAISGELDTTFAELTSF
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: WBBI_ECOLI
Sequence: MYFLNDLNFSRRDAGFKARKDALDIASDYENISVVNIPLWGGVVQRIISSVKLSTFLCGLENKDVLIFNFPMAKPFWHILSFFHRLLKFRIVPLIHDIDELRGGGGSDSVRLATCDMVISHNPQMTKYLSKYMSQDKIKDIKIFDYLVSSDVEHRDVTDKQRGVIYAGNLSRHKCSFIYTEGCDFTLFGVNYENKDNPKYLGSFDAQSPEKINLPGMQFGLIWDGDSVETCSGAFGDYLKFNNPHKTSLYLSMELPVFIWDKAALADFIVDNRIGYAVGSIKEMQEIVDSMTIETYKQISENTKIISQKIRTGSYFRDVLEEVIDDLKTR
What is the function of this protein?
Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6-linkage.  It uses n-octyl alpha-D-glucopyranoside as an acceptor substrate for the addition of galactofuranose from the donor substrate UDP-galactofuranose.  It is not able to use beta-D-glucopyranoside isomers.
What are the official names of this protein?
Beta-1,6-galactofuranosyltransferase WbbI, D-Galf:alpha-D-Glc beta-1,6-galactofuranosyltransferase, GalF transferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTU3C_STAAW
Sequence: MFKKLFGQLQRIGKALMLPVAILPAAGILLAFGNAMHNEQLVEIAPWLKNDIIVMISSVMEAAGQVVFDNLPLLFAVGTALGLAGGDGVAALAALVGYLIMNATMGKVLHITIDDIFSYAKGAKELSQAAKEPAHALVLGIPTLQTGVFGGIIMGALAAWCYNKFYNITLPPFLGFFAGKRFVPIVTSVVAIATGVLLSFAWPPIQDGLNSLSNFLLNKNLTLTTFIFGIIERSLIPFGLHHIFYSPFWFEFGSYTNHAGELVRGDQRIWMAQLKDGVPFTAGAFTTGKYPFMMFGLPAAAFAIYKNARPERKKVVGGLMLSAGLTAFLTGITEPLEFSFLFVAPVLYGIHVLLAGTSFLVMHLLGVKIGMTFSGGFIDYILYGLLNWDRSHALLVIPVGIVYAIVYYFLFDFAIRKFKLKTPGREDEETEIRNSSVAKLPFDVLDAMGGKENIKHLDACITRLRVEVVDKSKVDVAGIKALGASGVLEVGNNMQAIFGPKSDQIKHDMAKIMSGEITKPSETTVTEEMSDEPVHVEALGTTDIYAPGIGQIIPLSEVPDQVFAGKMMGDGVGFIPEKGEIVAPFDGTVKTIFPTKHAIGLESESGVEVLIHIGIDTVKLNGEGFESLINVDEKVTQGQPLMKVNLAYLKAHAPSIVTPMIITNLENKELVIEDVQDADPGKLIMTVK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in alpha- and beta-glucoside transport (By similarity).
What are the official names of this protein?
PTS system glucoside-specific EIICBA component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRN63_PHYSP
Sequence: MVKLFCAIVGAAGSAFPVDIDAGQSAGDLKDAIKAKNPATITCDAKDLQLSLAKTADGAWLPDDDQAALDLEDGKVHEDIQALIDGEKMKATWTIEDVLTANNMTKRKGRAPKSRQIHVLVVVPEGAFGSASETSKMDQLVEKVDKMYEQTVLGKRKYVHSEVTSTQGRQLLNDLDIRVEFVRTVPFDAGEGSSVDPYEWKRVIIENGEEVVLTEEQQRKRYRRYVEHNIGAVLKEKQLCVIGVERGTNILTVKVPGREIELAGRTDLLILSDLVAMRPTEVQYLPGVKMLIEVKRDVKASNDFQALSELIALDLLVDDPVMALLTDLKGEWIFFWVAEKINSSARIHKAAINKPGEAFEVIRALLVQPPTAPADTDTTEIKLPCFQSPVKRLKLRKALPPIGEGGDNGGIRESIERYYDIASMLGPDIEMARAVARQVTRSIPTFSYFS
What is the function of this protein?
Secreted effector that, with CRN115, is critical to pathogenesis by modulating host defenses (PubMed:21071601).  Induces cell death in plant host cells (PubMed:21071601).  Suppresses callose deposition and affects expression of defense-related genes including two salicylic acid (SA) signal-induced and antimicrobial PR genes (PR1 and PR2), and genes involved in jasmonic acid (JA)/ethylene (ET)-mediated defense pathway (ERF1, ORA59, PDF1. 2) (PubMed:27243217).  CRN115 and CRN63 may share the same molecular host targets that are involved in the cell death signal transduction pathway and that their differential activities are dependent on plant nuclear localization or not (PubMed:21071601).  Does not affect MAPK activation and BIK1 phosphorylation and acts downstream of the MAPK cascades in PTI signaling (PubMed:27243217).
What are the official names of this protein?
Crinkler effector protein 63.
What is the protein family that this protein belongs to?
Belongs to the Crinkler effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus, host nucleoplasm.
Protein: SACA9_RAT
Sequence: MNEVKESLRSIEQKYKLFQQQQFTFIAALEHCRENAHDKIRPISSIEQVQSYMEHYCNNSTDRRILLMFMDICSELNKLCQHFEALHSGTPVTNSLLEKCKTLVSQSNDLSILRAKYPHDVVNHLSCDEARNHYGGVVSLIPIVLDLMKEWIAHSEKLPRKVLQHGTT
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa.  May stabilize the protofilaments to which they are bound.
What are the official names of this protein?
Sperm acrosome-associated protein 9.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, flagellum. Nucleus. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome.
Protein: HSLO_CITBB
Sequence: MTDYLVRAIAKSGSVRALACVTTATVGAICKRHDTLPTATAALGRGITAGALMGALLKTGQRVAMRFEGNGPLKKIVIEADANGSVRGYVGDPKVHLLRPDGALDVNNALGRAGFLTVAKDLGLKEPYRGTVQLYTSGIAEDLALYLVESEQIPSAVGIAEFIEQDGTVAAAGGFLIQAVPPVDPLVIEELMTRIEQLPPLSELLHKGGNPEQILEQLLAGIPYDILEKRNIAFACSCSRERIERVLLSMGKKELSSMKKDQHGSEVTCEFCGEHYLFDEADLDRIIAEIAKQEG
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_XYLFM
Sequence: MKIIGIESSCDETGVAVYDTALSGSAALRAHSVYSQVALHAEYGGVVPELASRDHVRKLLPLLRQTLAEAKLSVEELDGVAYTAGPGLVGALLVGAGVARALAWALEVPAIGVHHMEGHLLSPLLEDDPPEVPFVALLVSGGHTQLVAVDAIGDYRLLGETLDDAAGEAFDKVAKLMGLPYPGGPQLAALAERGIPGRFCFTRPMVDRPGLDFSFSGLKTQVLLAWRNSDQSDAIRVDVARGFEDAVVDTLAIKCERALDTVACQTLVVAGGVGANKCLRARLQAMCRQRGGRACFPRPALCTDNGAMIAFAGALRLQAGQQSDVAVRVTPRWDMAALPPLVSRSCRR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GERKI_STRSQ
Sequence: MTADRWAGRTVLVTGALGFIGSHFVRQLDARGAEVLALYRTERPEIQAELAALNRVRLVRTELRDESDVRGAFKYLAPSIDTVVHCAAMDGNAQFKLERSAEILDSNQRTISNLLNCVRDFGVGEVVVMSSSELYSASPTVAAREEDDFRRSMRYTDNGYVLSKTYGEILARLHREQFGTNVFLVRPGNVYGPGDGFDCSRGRVIPSMLAKADAGEEIEIWGDGSQTRSFVHVADLVRASLRLLETGKYPEMNVAGAEQVSILELAGMVMAVLGRPERIRLDPSRPVGAPSRLLDLSRMSEVIDFDPQPLRAGLEETARWYRLHKR
What is the function of this protein?
Catalyzes the stereospecific reduction of the C-4 keto group of dTDP-4-dehydro-6-deoxy-D-allose, leading to dTDP-6-deoxy-D-allose, an intermediate in the biosynthesis of the mycinose moiety of dihydrochalcomycin (GERI-155) antibiotic.  Cannot directly reduce dTDP-4-dehydro-6-deoxyglucose, and thus acts after the epimerization step catalyzed by GerF.
What are the official names of this protein?
dTDP-4-dehydro-6-deoxy-D-allose reductase, dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase, dTDP-4-keto-6-deoxy-D-hexose reductase GerKI, dTDP-4-keto-6-deoxyallose reductase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: HIS8_DEHM1
Sequence: MTYDMKKYIRTDLEGFAGYSACKAPELVKTKNRIIKLDANENLYGAAPTVQKAMSTFDQYHIYPDATQFEIRRLLAEYTGVNMEQIICGAGSDQLIDLLLRLFINPGDEVINCPPTFAMYKFYTDLNRGTVVNVPRDAGYDVNIGGIKNALTPKTKLIFIAAPNNPTGTAISKEDIRQILDLGVPTVIDEAYYEFTGQTMVTDMPSYPNLMILRTFSKWAGLAGLRVGYGLFPPVIADYLSRIKDPYSVNIAADAAVRQTMLQREYMLETVKKIVDERKRLYTELSKFSWLKPYPSAANFILCKLLKGKAKDVQQALESQGILVRCFDAPMMENCLRFSVGKPEDTDALLKALGEMGE
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: 3SOD_ASPSC
Sequence: RKCFNSPGRLVSKPCPEGNNLCYKMSNRMYPPGFNVRRGCAETCPRRNRLLEVVCCCDTDNCNK
What are the official names of this protein?
Cytotoxin homolog S4C8.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group XIII sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IF1_YERPP
Sequence: MAKEDNIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_PSEPG
Sequence: MPRRRVAAKREILDDPKYGSQILAKFMNHVMESGKKAVAERIVYGALDTVKARKNSDPLEIFEKALDAIAPLVEVKSRRVGGATYQVPVEVRPSRRNALAMRWLVDYARKRGEKSMALRLAGELLDAAEGKGAAVKKREDVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.