PharMolix/UniProtQA huggingface dataset:
Protein: PLCD1_MOUSE
Sequence: MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  Essential for trophoblast and placental development.  Binds phosphatidylinositol 4,5-bisphosphate (By similarity).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, Phosphoinositide phospholipase C-delta-1, Phospholipase C-delta-1, PLC-delta-1.
Protein: PHNW_SALPC
Sequence: MTSRNYLLLTPGPLTTSRTVKEAMLFDSCTWDDDYNIGVVEQIRQQLTALATASEGYTSVLLQGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGIAHHAYDCGEVARPDVQAIDAILNADPTISHIAMVHSETTTGMLNPIDEVGALAQRYDKTYIVDAMSSFGGIPMDIAALHIDYLISSANKCIQGVPGFAFVIAREQKLAACKGHSRSLSLDLYAQWRCMEDNHGKWRFTSPTHTVLAFAQALKELAEEGGVAARHQRYQQNQRSLVAGMRALGFNTLLDDELHSPIITAFYSPEDPQYRFSEFYRRLKEQGFVIYPGKVSQSDCFRIGNIGEVYAADITALLTAIRTAMYWTK
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: PTHP_CHLMU
Sequence: MSGGDDLVLHNPVEDGELSAIFMIRNPSGIHVRPAGTIVKLFDGEDCEATFTYLGKTVNARSVMSILMLGASYNGEITVRIKGPSASRVMQKLAEVFNSGFGEL
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain.
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALYP_DROGR
Sequence: MSVAGGSISTAAGNAGKNNALPMAQLADGWLELESDPGLFTLLLEDFGCHDVQVEEVYDLQKPIESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGETLGRLKAHTKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVASCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHGCWEEHEDWTDKFRRVMAERLGIATGEQDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTLQKLLKADEQGERDEQQRPDTPTTLLEPSAFTARDLQSLLKNLDTEIAINEQHLADENDRRQMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKIANRLNRQTNAATAAANAANTNVAGTNAAGSKSQQQQQQTQQQPQQTQTAKNGKSPGKTPGRRRKGRNKCRKRK
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1).  Does not deubiquitinate monoubiquitinated histone H2B.  Required to maintain the transcriptionally repressive state of homeotic genes throughout development.  The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase calypso, BAP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family. BAP1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to PcG response elements (PREs).
Protein: CP9A_CONTE
Sequence: MHLSLARSAVLMLLLLFALGNFVVVQSGQITRDVDNGQLTDNRRNLQSKWKPVSLYMSRRGCNNSCQEHSDCESHCICTFRGCGAVNG
What is the function of this protein?
Neurotoxin.  In vivo, intracranial injection into mice of 10 pmol/g of the peptide induces running in circles and hyperactivity.  At higher doses (50 pmol/g), the mice exhibit running and climbing symptoms for close to one hour.  Between 130 and 150 pmol/g, characteristic 'spasmodic' symptomatology is elicited.  A hand clap would make mice jump high and start running rapidly.  When exposed to a loud hand clap, or if the cage cover were dropped, the mice lose motor control and exhibit seizure-like symptoms from which they eventually recover.  At the highest doses tested (over 250 pmol/g), after the characteristic spasmodic symptomatology, lethality occurs.  Injection of a similar dose range intramuscularly into Siamese fighting fish elicited no unusual symptomatology.
What are the official names of this protein?
Conotoxin tx9a, Spasmodic peptide.
What is the protein family that this protein belongs to?
Belongs to the conotoxin P superfamily.
Protein: RS9_THESQ
Sequence: MAEVIGYYGTGRRKTAVARVYLRPGEGKVKVNGKEYESLNDYFKNPAWTKHAIEPLEVTNTLGKFDLVIRVNGGGLSGQSGAVRLGIARALLQYDQNLRPVLKKYKMLTRDPREVERKKYGLKKARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: TRPF_MAGSA
Sequence: MPVEVKICGITDEDAMDVAIEEGADYVGLVFFPPSPRNVTPDRAAELVEFAPGDVTKVGLFVDPDDATLDTVLTRVRLDLLQLHGHETPERVEAIRLEYGLPVMKVLSVSDAADLDAAEPYLAVADRLLFDAKPPKGAVLPGGNAVSFDWSILTGRKWGLPWMLAGGLTPANVAEAVRISGAAAVDVSSGVESAPGIKDSDKIRAFIKAARGGRP
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: EX7S_PELTS
Sequence: MAEKEMNFEEALARLEAVVKELEDGRLPLQKALELFAEGIGLSRICNRYLEDAEQRIAILTADEKGGVVLRELGPSPAAREDTNDEL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPC2_NEUCR
Sequence: MRLSAAVIALLSTSAAAFSVYRENSVSANDELDVPGKSPLRFCDAAADRKDDIVTIEEVILTPNPPEAGQTLTIEASGIVKEAIEEGAYVNLQVKYGYIRLINTSADLCKEMKNVELECPIKKGRLSITKNVELPKEIPPGKYTVEADVYNSDDKHITCLTATVFFGRKTLGFLDDL
What is the function of this protein?
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
What are the official names of this protein?
Phosphatidylglycerol/phosphatidylinositol transfer protein, PG/PI-TP.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
Protein: INP1_ASHGO
Sequence: MARPTNSAASDVIPPSSKTRMPKIKPFKTIRTTFLKKKNTIGNLVSKGTHSSQSGGHKDSYMGDVESLTLRSPQSRGSWVESIDSKKIHSLSNDRVTLFRYEHVRVTSYQSVRKKYRNSGDSRRGQERMESAVKGTDVLRRERASVIEPRGPLEIYQIITPISKEPSQKVTYLCLGRKEQIIKPILPKLRITMLTREGLQFSVLSFNPENSWKIEFLGALGDSAVPCNVILAFENAVKNICRYTSELNNDPIEEVGTEDDDDLEYLLYSDFAEDDDTGSDITLNREHSSEPSDLLNCSTTNEMINDAFRKAIEHIRHVGSMPLIEAHGVKSFSSQLKIDGEQVDPPPKASPRQRAVSVPVETRTWSKLSTHPVALSTWMDIEYDDIKE
What is the function of this protein?
Required for peroxisome inheritance.
What are the official names of this protein?
Inheritance of peroxisomes protein 1.
What is the protein family that this protein belongs to?
Belongs to the INP1 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: HEMH_ACIC5
Sequence: MEERAAILLLAHGTPDSAEEIPEYLRNVVSGRPMPAEVIEEVRHRFVEIGGSPLTALTLQQGRLLQEALGLPVYVGMRNWKPYIADVVKQMVEDGITRAVAICLAPQNSRTSVGLYRRAVFAEAGQKMQIGFIEGWAEDDLLAAAFADRLRATWEPFRAEVGGPVPVLFTAHSVPCRTVQAPQPDPEAPRRPVLPPDPYNYEAKKTAMHVAAKVDGLDAWYFAFQSQGMSGGPWIGPTVEDTLTALHQEGIRHLVIQPVGFLCDHVEILYDIDIAFRDFAQNLGMMLRRPASLNDSPLLTAALARLAQSGLDRLQASEAPEPAAS
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGA13_CANAL
Sequence: MRSPSLAVAATTVLGLFSSSALAYYGNTTTVALTTTEFVTTCPYPTTFTVSTCTNDVCQPTVVTVTEETTITIPGTVVCPVVSTPSGSASASASAGASSEEEGSVVTTQVTVTDFTTYCPYPTTLTITKCENNECHPTTIPVETATTVTVTGEVICPTTTSTSPKESSSEAASSEVITTQVTVTDYTTYCPLPTTIVVSTCDEEKCHPTTIEVSTPTTVVVPGTVVCPTTSVATPSQSEVATKPTTINSVVTTGVTTTDYTTYCPSPTTIVVSTCDEEKCHPTTIEVSTPTTVVVPGTVVHPSTSATIITTTAEQPPASPEVSTIESVVTTPATLTGYTTYCPEPTTIVLTTCSDDQCKPHTVSATGGETVSIPATIVVPSSHTTQVEITVSSASVPASEKPTTPVTVAAVSSSPAVSTETPSLVTPAISIAGAAAVNVVPTTAFGLFAIILASIF
What is the function of this protein?
Cell wall protein which contributes to cell wall synthesis and is important for acquiring normal surface properties.  Required for virulence in a mouse infection model.
What are the official names of this protein?
GPI-anchored protein 13.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Protein: CASQ2_RABIT
Sequence: MKRAHLFVVGVYLLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQILKKYDLLCLYYHAPVSADKVAQKQFQLKEIVLELVAQVLEHKEIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIINSKLEVQAFERIEDHIKLIGFFKSADSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPTPIPNKPYTEEELVEFVKEHQRPTLRRLRPEDMFETWEDDLNGIHIVPFAEKSDPDGYEFLEILKQVARDNTDNPDLSIVWIDPDDFPLLVAYWEKTFKIDLFKPQIGVVNVTDADSVWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDNEDEDDDDDNDDDDDDNGNSDEEDNDDSDEDDE
What is the function of this protein?
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.  Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits.  Can bind around 60 Ca(2+) ions.  Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction.  Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
What are the official names of this protein?
Calsequestrin-2, Calsequestrin, cardiac muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the calsequestrin family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
Protein: FEN1_PYRTR
Sequence: MGIKHLYQLIEEHTPEAVKKGEIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMSETGETTSHLMGLFYRTMRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKTEAHAAAEEAKETGTAEDVEKFSRRTVRVTREHNEECQRLLKLMGIPYIVAPTEAEAQCAALARGGKVYAAASEDMDTLTFDTPILLRHLTFSEQRKEPILEIHLDKVLEGLQMERKQFIDLCILLGCDYLDPIKGIGPSTALKLIREHNDLEGVVEHIKSQSSKKLTIPDDWPFADARLLFLEPDVRPADDPECDFKWEAPDVEGLVKFLVEEKHFNEDRVRNGAAKLQKNMKTAQQSRLEGFFKPIEKTAEQKATLKRKADEKLEEKKKKQKVDAKAKKQAKAKPRTAG
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: BH133_ORYSJ
Sequence: MECSSFEAICNESEMIAHLQSLFWSSSDADPCFGSSSFSLISSEGYDTMTTEFVNSSTNVCFDYQDDSFVSAEETTIGNKRKVQMDTENELMTNRSKEVRTKMSVSKACKHSVSAESSQSYYAKNRRQRINERLRILQELIPNGTKVDISTMLEEAIQYVKFLHLQIKLLSSDEMWMYAPLAFDSGNNRLYQNSLSQE
What is the function of this protein?
Transcription factor that acts as regulator of iron homeostasis (PubMed:22755510).  May act as negative regulator of iron transportation from root to shoot (PubMed:22755510).  Does not seem to be involved in the suppression of the induction of iron deficiency responsive genes (PubMed:22755510).
What are the official names of this protein?
Transcription factor BHLH133, Basic helix-loop-helix protein 133, OsbHLH133, bHLH transcription factor bHLH133.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPB_ACTP2
Sequence: MATGKIVQIIGAVIDVEFPQDAVPKVYDALKVESGLTLEVQQQLGGGLVRCIALGTSDGLKRGLKVENTGNPIQVPVGTKTLGRIMNVLGEPIDEKGPIGEEARWDIHRAAPSYEEQSNSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDSTVVLSRNIASLGIYPAVDPLDSTSRQLDPLVVGEEHYNVARGVQGTLQRYKELKDIIAILGMDELSEDDKLVVARARKIERFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGILEGEFDHIPEQAFYMAGSIDEVVERASKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IOD2_HUMAN
Sequence: MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine).  Essential for providing the brain with appropriate levels of T3 during the critical period of development.
What are the official names of this protein?
Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYS_UREP2
Sequence: MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNNIKNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFKPKKFDFLPLAHWDLAVKNKLIDFDKSTKITGSRFIIYTNFGARLYRALQQFCLDMNVKAGFSEIWAPVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLHRNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRIVLCTGDLGFSSAKTYDLEVWLPSYNAYKEISSCSNCTNFQARRAKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENYQQEDGSINIPKVLKKYIY
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKB13_ARATH
Sequence: MSSLGFSVGTCSPPSEKRKCRFLVNNSLNKAEAINLRNKQKVSSDPELSFAQLSSCGRREAIIGFGFSIGLLDNVSALAETTSCEFSVSPSGLAFCDKVVGYGPEAVKGQLIKAHYVGKLENGKVFDSSYNRGKPLTFRIGVGEVIKGWDQGILGSDGIPPMLTGGKRTLRIPPELAYGDRGAGCKGGSCLIPPASVLLFDIEYIGKA
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Responsive of the major PPIase activity in the chloroplast thylakoid lumen.  Regulates the accumulation of Rieske protein, an essential component of the photosynthetic electron transport chain.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic, PPIase FKBP13, FK506-binding protein 1, FK506-binding protein 13, AtFKBP13, Immunophilin FKBP13, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
Protein: LIPA_ECO7I
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_BLVB5
Sequence: MPKERRSRRRPQPIIRWVSLTLTLLALCQPIQTWRCSLSLGNQQWMTTYNQEAKFFISIDQILEAHNQSPFCPRSPRYTLDFVNGYPKIYWPPPQGRRRFGARAMVTYDCEPRCPYVGADHFDCPHWDNASQADQGSFYVNHQTLFLHLKQCHGIFTLTWEIWGYDPLITFSLHKIPDPPQPDFPQLNSDWVPSVRSWALLLNQTARAFPDCAICWEPSPPWAPEILVYNKTISSSGPGLALPDAQIFWVNTSLFNTTQGWHHPSQRLLFNVSQGNALLLPPISLVNLSTASSAPPTRVRRSPVAALTLGLALSVGLTGINVAVSALSHQRLTSLIHVLEQDQQRLITAINQTHYNLLNVASVVAQNRRGLDWLYIRLGFQSLCPTINEPCCFLRIQNDSIIRLGDLQPLSQRVSTDWQWPWNWDLGLTAWVRETIHSVLSLFLLALFLLFLAPCLIKCLTSRLLKLLRQAPHFPEISFPPKPDSDYQALLPSAPEIYSHLSPTKPDYINLRPCP
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: PALM3_MOUSE
Sequence: MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARRELEEEKLRVERLKRKSLRERWLMDGAAEGPERPEEPASKDPQSPEGQAQARIRNLEDSLFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQSAMEAAPTAPTDVDKRTSLPDAPVGMSPESPSDPREESIAVLPASRPSTEAIGTSSEANGPCPGHSPLPEQLSLGVSSVTKAKGDGAVEVVWAGLRATENSATGPTDVELEAKVEEVVLEAIGARQGTSSPELPTWVKEGRGVVEVVWEGLGGRDLDVTGESGRDAEATHTSSRRLQEQFEAETCRKEEGASRDSLEGVGQGGPGVEEGSFIWVERVALSEDWEEILMEGLEAPQGAGSAGEPEALIGAQPRGGEASWEVEKREVEKVEGIEEKGRAEKLGAEREDGVAVLPDETQGREENEAEKVERKDSEGPFPAEIATDEEKWEVKTTEGEESLEVEKGGEAEPVTTEKPLVTEKKPEGSLETERKGSEMPLDQEKDGEGSLDRESKTTEILLDGEIGDKSSLDETKGSKKLLDEKTGGEGSLDEEAEGSKKLLDREADGIEPFSEVDKTSGAKDDVSPEEQGKANEGAEFQAEDASPPGATVCVQDEPRSEEQGQQEPEKQEGLVEGAASKPEPCTEREGPPGDATLLLAETPAPEQPVESQPLLHQEASSTNPGDHPAPTYAPAQQLELAEAKEASGPKQKTCQCCVVM
What is the function of this protein?
ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.
What are the official names of this protein?
Paralemmin-3.
What is the protein family that this protein belongs to?
Belongs to the paralemmin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor.
Protein: NUD14_HUMAN
Sequence: MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQFRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIEVVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ
What is the function of this protein?
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP.  The physiological substrate is probably UDP-glucose.  Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
What are the official names of this protein?
Uridine diphosphate glucose pyrophosphatase NUDT14, UDPG pyrophosphatase, UGPPase, Nucleoside diphosphate-linked moiety X motif 14, Nudix motif 14.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEAP2_BOVIN
Sequence: MWHLKLFAVLMICLLLLAQVDGSPIPQQSSAKRRPRRMTPFWRAVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
What is the function of this protein?
Has an antimicrobial activity.
What are the official names of this protein?
Liver-expressed antimicrobial peptide 2, LEAP-2.
What is the protein family that this protein belongs to?
Belongs to the LEAP2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YOHJ_SHISS
Sequence: MSKTLNIIWQYLRAFVLIYACLYAGIFIASLLPVTIPGSIIGMLILFVLLALQILPAKWVNPGCYVLIRYMALLFVPIGVGVMQYFDLLRAQFGPVVVSCAVSTLVVFLVVSWSSQLVHGERKVVGQKGSEE
What are the official names of this protein?
UPF0299 membrane protein YohJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.