PharMolix/UniProtQA huggingface dataset:
Protein: SYC2L_MOUSE
Sequence: MSTLQSLIIDGFHGNGFHMIEEYLQQKESHVPQKYNHLLLHHLDRLIKEELDKNEFQNCSLLLKCIQRFFRDDPDHEEPLLIQQGLIPKMVSWFEIITGLLITKVLASEALLTNALEDFLDTALIISRHSRKATVQMLDSFILRLGFLVAEDSVKPSIQQETLATLNCILNAAPQEERRKLSSAEGACCLMKELARTILTVGDYSQQVALSEALCRMSVGRQRNDLAMQWFENTALAEAFKKIKNREFETDCRQFLNFLNNRLGNQRRVYSFPCLAAFADGQEMRKPADEKLEEFWIDFNLGSQSVTFYIDNAESALWEPVKLLKEAMVKFIIIENDRIKMFIVYLKQPIVISKREAKKIEIHFDRQLGILQASIQALGEDKQAPSFQTSVLVKLFSGLEKEDGEIPGRCEREAEDAEESTLLPELVDAEADRCLITRCFNVQTVPGVSKGSLEITNTEERSLENSKQDEPEQVTSEYDYPLDMQEPSIQNQASDLNNIKEDSAFARDREQDRRMPFNDRNHDLLESNEDSSLSTNERSWTQNHKRKSLRTYSQRKKQRVSSLRILPLSPIRSGHAPEKDEAELVPLWKGISRRNDSTLLKISETKLRGSSVLLTSGASTQKIGLEKPERRGSEPSSSTKKTRVTDGLHWREPRSPHPSSGPSSLEYLEVEENIPEIVNRESFMGNSSFKHKLENLGHREIPDGSVAALKQSRLEDAPGSPVVTDTSTPSQEDMPGSVNGSAFKTAFENFTRDLKRKFELELKQREIPFSLEKAKEAPACLIRLWNQIHTCRLDTLERFHSSVLRELSGLEKNLQTLKCLEKDALASLLFVLSLGRERTFSR
What is the function of this protein?
Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes.
What are the official names of this protein?
Synaptonemal complex protein 2-like, SCP-2-like.
What is the protein family that this protein belongs to?
Belongs to the SYCP2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes (PubMed:26362258). Localizes to centromeres in dictyate oocytes (PubMed:26362258). Detected in nuclear granules and sizable aggregates (By similarity).
Protein: PTP16_STYPL
Sequence: WRMVTEHTSTVIVMLTGLVEKGKKKCEKYWPDLGRRATYGQIALKTVDETHVGSYIKRMLEITSNGKMQFIHHFQFTSWPDYGVPVATSDLFRFHKAVTRIKTQKPIVV
What are the official names of this protein?
Tyrosine-protein phosphatase 16.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: CYSH_HALH5
Sequence: MDQSIQVNINEVNQALERKDSLDVIKWAYKTYGDKLVYACSMGAEGMVLIDLISKVRPDAPVIFLDTDFHFSETYELIERVKERYPKLQLKLVKPELTPEEQAETYGDRLWERQPDLCCKLRKLVPLEKELAQYDAWMSGLRRDQSPTRTNTQFVNEDRRFGSTKICPLIHWTSEEIWMYIELHQLPYNDLHDKQYPSIGCEYCTRPVKEGEDERAGRWSNTSKTECGLHQ
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
Protein: GPNMB_MOUSE
Sequence: MESLCGVLGFLLLAAGLPLQAAKRFRDVLGHEQYPDHMREHNQLRGWSSDENEWDEHLYPVWRRGDGRWKDSWEGGRVQAVLTSDSPALVGSNITFVVNLVFPRCQKEDANGNIVYEKNCRNDLGLTSDLHVYNWTAGADDGDWEDGTSRSQHLRFPDRRPFPRPHGWKKWSFVYVFHTLGQYFQKLGRCSARVSINTVNLTAGPQVMEVTVFRRYGRAYIPISKVKDVYVITDQIPVFVTMSQKNDRNLSDEIFLRDLPIVFDVLIHDPSHFLNDSAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNLNLTVQTAVPGPCPPPSPSTPPPPSTPPSPPPSPLPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVEGILEVSIMQIADVPMPTPQPANSLMDFTVTCKGATPMEACTIISDPTCQIAQNRVCSPVAVDGLCLLSVRRAFNGSGTYCVNFTLGDDASLALTSTLISIPGKDPDSPLRAVNGVLISIGCLAVLVTMVTILLYKKHKAYKPIGNCPRNTVKGKGLSVLLSHAKAPFFRGDQEKDPLLQDKPRTL
What is the function of this protein?
Could be a melanogenic enzyme.
What are the official names of this protein?
Transmembrane glycoprotein NMB, DC-HIL, Dendritic cell-associated transmembrane protein, Osteoactivin.
What is the protein family that this protein belongs to?
Belongs to the PMEL/NMB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Melanosome membrane; Single- pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: DER_MYCTA
Sequence: MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: NUOI_MAGSA
Sequence: MSFLDRTARAFLLTELVQGLALTLRYMFKPKVTINYPYEKGPLSVRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEPEPRDDGSRRARRYDLDMTKCIYCGLCQEACPVDAIVEGPNFEYATETRAELMYNKSKLLANGDRWEAELAFRIAADAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YDFI_BACSU
Sequence: MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLADELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLLKDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAIAKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN
What is the function of this protein?
Member of the two-component regulatory system YdfH/YdfI.  Regulates the transcription of ydfJ by binding to its promoter region.
What are the official names of this protein?
Transcriptional regulatory protein YdfI.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1714_ARCFU
Sequence: MGEVTIKVSVPDNAEKAFRKAVEETAKFFNERDRFFELMNELKGVIKTDKSWMELKRDLV
What are the official names of this protein?
Uncharacterized protein AF_1714.
Protein: ODPB_CAEEL
Sequence: MALRKCGNLFVARLAGTSTRAASTMTVRDALNQAMDEEIKRDDRVFLMGEEVAQYDGAYKISKGLWKKHGDKRVVDTPITEMGFAGIAVGAAFAGLRPICEFMTFNFSMQAIDQIINSAAKTYYMSAGRVPVPIVFRGPNGAAAGVAAQHSQDFSAWYAHCPGLKVVCPYSAEDAKGLLKAAIRDDNPVVFLENEILYGQSFPVGDEVLSDDFVVPIGKAKIERAGDHVTIVSYSRGVEFSLEAAKQLEAIGVSAEVINLRSLRPFDFESIRQSVHKTHHLVSVETGWPFAGIGSEIAAQVMESDVFDQLDAPLLRVTGVDVPMPYTQTLEAAALPTAEHVVKAVKKSLNIA
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, PDHE1-B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CHB8_BOMMO
Sequence: GGLGGGCGRGFSGGGLPVATASAAPTGLGIASENRYEGTVGVCGNLPFLGTADVAGEFPTAGIGEIDYGCGNGAVGITREGGLGYGAGYGDGYGLGYGGYGGGYGLGYGGYGGCGCGCG
What is the function of this protein?
This protein is one of many from the eggshell of the silk moth.
What are the official names of this protein?
Chorion class B protein M2807.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: PRSA_STAES
Sequence: MKLMNKIIVPVTASALLLGACGSNATESKDNTLISSKAGDVKVADVMKKMGKEQIANTSFSIVLNKVLADKYKDKVDTKDIDKDIKKEEKQYGGKDQFESMLKQQGMSFDDYKEQKKLSAYQKQLLLDKVNVSDKEIKENSKKASHILIKVKSKSSDKEGLSDKKAKEKAEKIQKEVEKNPNKFGEIAKKESMDSSSAKKDGSLGYVIKGQMVDSFEKALFKLKEGEVSKVVKTDYGYHIIKADKETDFNSEKSNIKQKLIEEKVQKKPKLLTDAYKELLKEYKVDYKDRDIKKAIEDSILDPDKIKQQQQQQSQGGSGLTNSGS
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PFD5_BOVIN
Sequence: MAQSVNITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLKKNNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.  Represses the transcriptional activity of MYC (By similarity).
What are the official names of this protein?
Prefoldin subunit 5.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COMF_HAEIN
Sequence: MMNFFNFRCIHCRGNLHIAKNGLCSGCQKQIKSFPYCGHCGSELQYYAQHCGNCLKQEPSWDKMVIIGHYIEPLSILIQRFKFQNQFWIDRTLARLLYLAVRDAKRTHQLKLPEAIIPVPLYHFRQWRRGYNQADLLSQQLSRWLDIPNLNNIVKRVKHTYTQRGLSAKDRRQNLKNAFSLAVSKNEFPYRRVALVDDVITTGSTLNEISKLLRKLGVEEIQVWGLARA
What is the function of this protein?
Involved in transformation (competence for DNA uptake).
What are the official names of this protein?
Competence protein F, DNA transformation protein ComF, Protein COM101A.
What is the protein family that this protein belongs to?
Belongs to the ComF/GntX family.
Protein: T3HPD_AZOBR
Sequence: MKITRSLSTVEVHTGGEAFRIVTSGLPRAPGDTIVQRRAWLKENADEIRRALMFEPRGHADMYGGYLTEPVSPNADFGVIFVHNEGYSDHCGHGVIALSTAAVELGWVQRTVPETRVGIDAPCGFIEAFVKWDGEHAGPVRFVNVPSFIWQRDVSVETPSFGTVTGDIAYGGAFYFYVDGAPFDLPVREAAVEKLIRFGAEVKAAANAKYPVVHPEIPEINHIYGTIIANAPRHPGSTQANCCVFADREVDRSPTGSGTGGRVAQLYQRGLLAAGDTLVNESIVGTVFKGRVLRETTVGDIPAVIPEVEGSAHICGFANWIVDERDPLTYGFLVR
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  Together with LhpI, is involved in a t3LHyp degradation pathway to L-proline, which allows A. brasilense to grow on t3LHyp as a sole carbon source.
What are the official names of this protein?
Trans-3-hydroxy-L-proline dehydratase, T3LHyp dehydratase, t3HypD, Trans-L-3-hydroxyproline dehydratase.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: OB57D_DROME
Sequence: MPEKMSLRLVPHLACIIFILEIQFRIADSNDPCPHNQGIDEDIAESILGDWPANVDLTSVKRSHKCYVTCILQYYNIVTTSGEIFLDKYYDTGVIDELAVAPKINRCRYEFRMETDYCSRIFAIFNCLRQEILTKS
What is the function of this protein?
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
What are the official names of this protein?
General odorant-binding protein 57d.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
Protein: MCSB_BACP2
Sequence: MSLQHFIQDALSQWMKQKGPESDIVLSSRIRLARNLEHVRFPTQFSQEEAQAVLQQFEQKFASQEVKDIGNFVLIRMNETQPLAKRVLVEKHLISPNLAESRFGGCLLSENEEISVMLNEEDHIRIQCLFPGFQLANALKAANQIDDWIEEQVDYAFSEKRGYLTSCPTNVGTGIRASVMMHLPALALTRQMNRIIPAINQLGLVVRGIYGEGSEAIGNIFQISNQMTLGQSEEDIVDDLNSVTAQLIEQERSARKALYQTSKIELEDRVYRSLGILSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALEPNERDIKRAAIIRERLRLEMHRNGQEDETI
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in a large number of proteins.  Is part of the bacterial stress response system.  Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: LEUC_STACT
Sequence: MGQTLFDKIWNRHVLTGKEGEPQLLYIDLHLIHEVTSPQAFEGLRIQKRPLRRPDLTFATIDHNVPTEDIFNIRDEIAATQIKTLQNNCAEFDVKLFDNGTDQQGIVHMVGPEMGLTQPGKTIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQSLWQTKPKNLLIDINGKLPQGVYAKDIILHLINQYGVDFGTGYALEFGGSTMRNLSMDERMTICNMAIEAGAKYGLVQPDETTLEYVKDRPYADLTPEKLEYWKTLYSDEDAQFDCVIELDVTQLEPQVTWGTSPEMGVSFSTPFPAIENINDERAYQYMGLKPGEKAEDIELGYVFLGSCTNARLSDLVEASKFVKGHQVHPNITAIVVPGSRSVKHQAEALGIDKIFKDAGFQWREPGCSMCLGMNPDQVPAGVHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIEGRFIDVRNWEAVINA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS15_POLNS
Sequence: MAVADIKTAKIVKENARSANDTGSPEVQVSLLTARINELTPHFKANTKDHHSRCGLLKMVSRRRRLLDYLKGKDLDCYRALIEKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: A1BG_PIG
Sequence: ALFLDPPPNLWAEAQSLLEPWANVTLTSQSRLPVLNFQGL
What are the official names of this protein?
Alpha-1B-glycoprotein, Alpha-1-B glycoprotein, Plasma protein PO2-F.
What are the subcellular locations of this protein?
Secreted.
Protein: GATC_BOVIN
Sequence: MWARAVHLGLRAAARGRRGFTSKADPQGSGRVTGELIQHLERLSLVDFGSQEAVARLEKAIAFADRLRAVNTDGVEPMESVLEDRCLYLRSDNVVEGSCAEELLQNSHRVVEEYFVAPPGNISWSKLDEKQPFSHR
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VRAS_STAA1
Sequence: MNHYNRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
What is the function of this protein?
Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae.  Modulates also quorum-sensing signal production acting on both negative and positive modulators.  Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
What are the official names of this protein?
Sensor protein VraS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNME_LEPBJ
Sequence: MNDTIAAVSTASGPGAIGIIRMSGPGALSISSSFLFSKNGFLSPSDIQPRIAIQCVFQIGDRKIDQILFFYFKTPNSYTGEDLCEFHFHGNPILLREALDAIFRAGARPAKQGEFSRRAFLNGKLDLTGVEAIGRLISARSRFELELAQKNVFGEVSRLTSNLRSQLISLKAECEAEIDFSTEDLTYESLEERKVRIEGVKTFCQTVIAKSNSAEKVIQQLRIVLYGEPNTGKSSLMNVLLGKDRSIISEIPGTTRDYISEEILLEGIPVRLVDTAGVRETEDHIERLGIERSEKEFQSADIRLFLIDVSKKEEWKKFIAKAKGRLEGSILVANKIDIRDSSWNPNLFSDVKDLIICEISCKTKEGIPILLDEIQKKAATMGHVEDYVLLEERQRYHFETIVRCLDKTLRLIEEGAPAEIYIQEMNYALSEIGEVNGRVDTEEVLGRIFSKFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAM1_MOUSE
Sequence: MPLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAVYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIKTEKKTVQFNDDVQIETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQQYYLQSSAVSASQVYPGPAQSGTYLVAGSAQMTHLQSYSLPPEQLSSISQGAVPSSANQALPSQQTQASYPNAMVSSVQGNSYPSQASIYSPPAAAAAAAAAAVVPVPVPADVTIYQNAGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQAYSQKALL
What is the function of this protein?
Involved in intracellular signal transduction mediated by cytokines and growth factors.  Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction.  May also play a role in T-cell development.  Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex).  The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
What are the official names of this protein?
Signal transducing adapter molecule 1, STAM-1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LFTR_LEGPL
Sequence: MAYDSNYTFPDPETSDKQGLLAIGGVLTPKRVLQAYSQGIFPWYEPGNPVLWWSPNPRLILIPNEFKISRSLKKTLKKPFKLTVDTAFQRVISYCATCSDRANKTWITSEMIETYTQLHEMGYAHSFEIWDGSELVGGLYGISLGHAFFGESMFHTITDASKVALHFLCSIMQSWNFDFIDCQLPTLHLMRLGAKIISRKEFLHMLQETLKYPDKKGNWSVN
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_CORGB
Sequence: MSDVERTEFEIPGGIPPRRNGGQGRAADTNVDANLKPDEYDAEVTLRPKSLTEFIGQPKVRDQLSLVLTGAKNRGVVPDHVLLSGPPGLGKTTMAMIIAQELGTSLRMTSGPALERAGDLAAMLSNLMEGDVLFIDEIHRIARPAEEMLYMAMEDFRIDVIVGKGPGATSIPLEIPPFTLVGATTRSGMLTGPLRDRFGFTAQMEFYDVPDLTKVVKRTAKILDVGIDNDAAVEIASRSRGTPRIANRLLRRVRDFAEVHADGHITMGAANAALIVFDVDEVGLDRLDRAVLDALIRGHGGGPVGVNTLAVAVGEEPGTVEEVCEPYLVRAGMIARTGRGRVATAAAWRHLGLEPPEGTIGDY
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SYT_THEKO
Sequence: MRMLLIHSDYLEYEVKDKALKNPEPISDEQKTGRLDEVLAVFISVEKVDETNPDEVVEKAVKEIEDVASQIKAERIFVYPFAHLSSELAKPDVALEVLRKIEEKLREKGYEVKRAPFGYYKAFKLSCKGHPLAELSRTIVPEKAVSKEERNIALEKEEKELKSYWYILTPEGELIDVDKFDFTGHENLKKFVNYEIAKNRVADREPPHVRLMLEQELVDYEPGSDAGNLRYYPKGRLIKSLLEQYVTEKVIEYGAMEVETPIMYDFEHPALEKYLNRFPARQYVVKSGDKKFFLRFAACFGQFLIKKDATISYRNLPLRMYELTRYSFRREKSGELSGLRRLRAFTMPDMHTVARDLKQAMDEFKKQYKLSMEVLKGVGLTPEDYEVAIRFTRDFWEQNRDFIVELAKIIGKPVLIEMWDQRFFYFILKFEFNFVDNLDKAAALSTVQIDVENAERFGIKYYDEEGKERTPLILHCSPSGAIERVMYAILEKQAKLQEKGIKPMYPLWLSPIQVRVIPVSDEVMDYALYVAGKLEGAKIRVDVDDTGDRLNKKIRKAEKEWIPYIIVVGRNEKEQNTVTVRRRSDGRQVEMQLEDLIREIKGQTEGFPYKPRPLPLLLSRRPKFRG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR7_LEMMI
Sequence: MSRRGTAEKKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDIAVKSRRVGGSTHQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHKMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: METN1_LACPL
Sequence: MTEAIIDLKDIAVTFDDGHQVVHAVQDVNLQIQTGDIYGIIGYSGAGKSTLVRVINLLQSPTTGQVVVNGQALQTLSPAALRQARKHVGMIFQHFNLMQSRTVMGNVIYPLLGQKISKQNRRAKALRLLKLVGLTDYAQTYPDKLSGGQKQRVAIARALVTDPQILISDEATSALDPKTTTAILELLQRVNRELGITIVLITHEMQVIKSICHHVAVMADGRIIERGPVAEVFTAPKAPLTVDFVETSTNVRAAIQRITKTIKLSELAAGQELIAFKFVGQSTKQGIVSQLSQTLGVDVNILFANIDQIDGQNVGDMIAIITGDLTAFNAAVTNMSAQGVHTRIINEEVVKGMVD
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.