PharMolix/UniProtQA huggingface dataset:
Protein: CH601_BURCH
Sequence: MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDSSIGDRIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQVAKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVVAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIRARTAIAGLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNAATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POL_MPMV
Sequence: MGQELSQHERYVEQLKQALKTRGVKVKYADLLKFFDFVKDTCPWFPQEGTIDIKRWRRVGDCFQDYYNTFGPEKVPVTAFSYWNLIKELIDKKEVNPQVMAAVAQTEEILKSNSQTDLTKTSQNPDLDLISLDSDDEGAKSSSLQDKGLSSTKKPKRFPVLLTAQTSKDPEDPNPSEVDWDGLEDEAAKYHNPDWPPFLTRPPPYNKATPSAPTVMAVVNPKEELKEKIAQLEEQIKLEELHQALISKLQKLKTGNETVTHPDTAGGLSRTPHWPGQHIPKGKCCASREKEEQIPKDIFPVTETVDGQGQAWRHHNGFDFAVIKELKTAASQYGATAPYTLAIVESVADNWLTPTDWNTLVRAVLSGGDHLLWKSEFFENCRDTAKRNQQAGNGWDFDMLTGSGNYSSTDAQMQYDPGLFAQIQAAATKAWRKLPVKGDPGASLTGVKQGPDEPFADFVHRLITTAGRIFGSAEAGVDYVKQLAYENANPACQAAIRPYRKKTDLTGYIRLCSDIGPSYQQGLAMAAAFSGQTVKDFLNNKNKEKGGCCFKCGKKGHFAKNCHEHAHNNAEPKVPGLCPRCKRGKHWANECKSKTDNQGNPIPPHQGNRVEGPAPGPETSLWGSQLCSSQQKQPISKLTRATPGSAGLDLCSTSHTVLTPEMGPQALSTGIYGPLPPNTFGLILGRSSITMKGLQVYPGVIDNDYTGEIKIMAKAVNNIVTVSQGNRIAQLILLPLIETDNKVQQPYRGQGSFGSSDIYWVQPITCQKPSLTLWLDDKMFTGLIDTGADVTIIKLEDWPPNWPITDTLTNLRGIGQSNNPKQSSKYLTWRDKENNSGLIKPFVIPNLPVNLWGRDLLSQMKIMMCSPNDIVTAQMLAQGYSPGKGLGKKENGILHPIPNQGQSNKKGFGNFLTAAIDILAPQQCAEPITWKSDEPVWVDQWPLTNDKLAAAQQLVQEQLEAGHITESSSPWNTPIFVIKKKSGKWRLLQDLRAVNATMVLMGALQPGLPSPVAIPQGYLKIIIDLKDCFFSIPLHPSDQKRFAFSLPSTNFKEPMQRFQWKVLPQGMANSPTLCQKYVATAIHKVRHAWKQMYIIHYMDDILIAGKDGQQVLQCFDQLKQELTAAGLHIAPEKVQLQDPYTYLGFELNGPKITNQKAVIRKDKLQTLNDFQKLLGDINWLRPYLKLTTGDLKPLFDTLKGDSDPNSHRSLSKEALASLEKVETAIAEQFVTHINYSLPLIFLIFNTALTPTGLFWQDNPIMWIHLPASPKKVLLPYYDAIADLIILGRDHSKKYFGIEPSTIIQPYSKSQIDWLMQNTEMWPIACASFVGILDNHYPPNKLIQFCKLHTFVFPQIISKTPLNNALLVFTDGSSTGMAAYTLTDTTIKFQTNLNSAQLVELQALIAVLSAFPNQPLNIYTDSAYLAHSIPLLETVAQIKHISETAKLFLQCQQLIYNRSIPFYIGHVRAHSGLPGPIAQGNQRADLATKIVASNINTNLESAQNAHTLHHLNAQTLRLMFNIPREQARQIVKQCPICVTYLPVPHLGVNPRGLFPNMIWQMDVTHYSEFGNLKYIHVSIDTFSGFLLATLQTGETTKHVITHLLHCFSIIGLPKQIKTDNGPGYTSKNFQEFCSTLQIKHITGIPYNPQGQGIVERAHLSLKTTIEKIKKGEWYPRKGTPRNILNHALFILNFLNLDDQNKSAADRFWHNNPKKQFAMVKWKDPLDNTWHGPDPVLIWGRGSVCVYSQTYDAARWLPERLVRQVSNNNQSRE
What is the function of this protein?
Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.
What are the official names of this protein?
Gag-Pro-Pol polyprotein, Pr180.
What is the protein family that this protein belongs to?
Belongs to the retroviral Pol polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p10]: Virion. SUBCELLULAR LOCATION: [Capsid protein p27]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein-dUTPase]: Virion. SUBCELLULAR LOCATION: [Protease 13 kDa]: Virion. SUBCELLULAR LOCATION: [Protease 17 kDa]: Virion.
Protein: APT5_ARATH
Sequence: MFAAENGLKGDPRLEAISAAIRVVPNFPKKGIMFQDITTLLLDHKAFKHTIDIFVDRYKDMQISVVAGVEARGFLFGPSIALAIGAKFIPLRKPGKLPGKVISESYELEYGHDRLEMHVGAVEPRERVIIIDDLVATGGTLSAAMSLLESQGAEVVECACVIGLPEVKGQHKLKGKPLYVLVEPSGLDEFC
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.  May contribute to the recycling of adenine into adenylate nucleotides and the inactivation of cytokinins by phosphoribosylation.  Possesses low activity toward adenine, but can efficiently convert cytokinins from free bases (active form) to the corresponding nucleotides (inactive form).
What are the official names of this protein?
Adenine phosphoribosyltransferase 5, AtAPT5.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_RUMCH
Sequence: MEMLLGTDIIEVDRIKRAIENGGRKFSEKVFTLNEIEYCESRKAGKYQSYAARFAAKEAVSKAFGTGIGKNAAFSEIEILKDSLGKPYVRLSGKAKEFYDSLGTAGISVSLSHCRAYAVAYAVISLGDSFKNKI
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4053_ENTFA
Sequence: MTKKEQSIWRKEMLALMNEDADWYRNEDTERFKRIQELAKKIETASTRQFSSHISKERFEAYQRMGLQFKEIAEEFHITTTALQQWRKDNGYPIYNKNNRK
What is the function of this protein?
Might be involved in the expression of prgA, but is not required for activation of the expression of prgB.
What are the official names of this protein?
Putative regulatory protein PrgT.
Protein: RPOB_DEHMC
Sequence: MVSMLPKADAATGVIRKSYAQLPEVVNVPNLIEMQLQSFVWFQEEGLRELIEEISPIKDFVGNRLELEFIGYEFREPRLSEYECTQRDQTYSVPLYVKARLIVKTTGEIKEPFDLFFGDIPLMTALGTFITSGTERVVVSQLLRSPGVYFTISDDPATGRPLCHTNLIPSRGAWLEFETSNRDVISVKIDGRRKIPVSTLLRAIGYSDDLDILNLFEVIDNDPERHYIQSSIDRDPLIKDEISALIDIYSRLRPGDPPNADNARKLINEMFFDPQHYDLGKVGRYKVNRRLELPSREVGENRALTREDIVAIIQRIIMVNNGQDTPDDIDHLGNRRIRTVGELVQNQFRIGLVRLERVARERMSIVNLEMVTPSALVNIRPVVSAVKEFFGGSQLSQFMDQTNPLAEITNKRRLSAMGPGGLSRERAGFDVRDVHYSHYGRICPIETPEGPNIGLIGSLATYSRINRYGFVETPYRKVYSKLKNNDKKLVGLKLKIEISEKGKVLAAAGSTISEDSFKLISKLPECDISVMPFVSAEVKYMPADEEDRYIIAQANTRLDEKGYFLDDRIEARSAERYVVEPPDKIDYMDVSPKQIFSVAASLIPFLEHDDANRALMGANMQRQAVPLLRAEAPMVATGMEREAARYSGQVIFAKHAGVASSVTSEKIIIRTAEGGHDEYLLKKFVRTNQGTCINQHAIINKGQKIAAGQVLADSSATENGELALGQNCVVAFMSWQGFNYEDAIILSERLVREDAFTSIHITKHELEARDTKLGVEEITRDIPNVGEESLRELDEDGIIRIGAEVGPDDILVGKITPKGETELSAEEKLLRAIFGEKAREVKDTSLRMPHGEWGKVINVRIFSRDSGDDLPARVNKWVQVWVAQKRKVSVGDKLAGRHGNKGVISIIAPVEDMPYLPDGTPVDVVLNPIGVPSRMNLGQILETHLGWAGHLLGFRVATPVFDGADDTVIEDALARSWLSAKAGAIDMSPENKRPSADAHKAIEWIKQQGFDGKKIFDEKHPGLAKEVSLKLWLKDMGVDASALSGAELEKKAYDVSSQSRLPSPIVGKSVLRDGRTGETFDQPVTVGNMYILKLIHLVEDKVHARATGPYSLISQQPLGGKAQFGGQRFGEMEVWAMYAYGTAHNLQEMLTIKSDDIAGRAKAYESIVKGEDVLQPGVPESFKVLVKELQSLGLAVEVINEEVKIAPSEKVSSLNEGNLPASDEISAEILPETLYANTEDISEDSMMSVIDADDQDLVVSSNDEEVSENDERS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: HDLC_ARCPA
Sequence: MEMMEEGVPDVINLSYLAEREETELEKRVAEIIKELGAERLMYCMQCGACASICPLARVGFEWYNKKLIKALILGLRDELLDDPTPWACVACNRCTEICPRRVSPFEVMFAMRRLMAEEYAIGSLAIEGLRSLYEYGHAVYMAGREARKKVGLPEKPPSTESDPKALEDLRKILKQTKLAELGLVPME
What is the function of this protein?
Has oxidoreductase activity.  The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.
What are the official names of this protein?
Heterodisulfide reductase subunit C-like protein.
What is the protein family that this protein belongs to?
Belongs to the HdrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_THEAC
Sequence: MVSYKARISLSGTEHRVVDRVCNEIKEIASRTGVEIHGPMPLPTKRLVVPVRKSPDGEGTNTWDHWEMRIHKRLIDVDADERTLRQLMRIPIPDGVQIEIQIKS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: TRXR2_BOVIN
Sequence: MAALRGAAARFRGRAPGGARGAAGRQCYDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAPHYGWGVAQAPHSWATLADAVQNHVKSLNWGHRIQLQDRKVKYFNVKASFVDTHTVCGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLFWLKESPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHMAGHGTRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGVHTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDYSSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRDASQCYIKMVCLREPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHPTCAEEVAKLRISKRSGLDPTVTGCUG
What is the function of this protein?
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity).  Maintains thioredoxin in a reduced state.  May play a role in redox-regulated cell signaling.
What are the official names of this protein?
Thioredoxin reductase 2, mitochondrial, mt-TR, Thioredoxin reductase TR3.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPF_BACC2
Sequence: MSQFSFTKMHGLGNSYIYVNMFEEQIPEEDLVLVAEKVSNINTGIGADGMILICPSDVAPVKMRMFNNDGSEGKSCGNGLRCVAKYAYEHKLVEETVFTIETLAGIVTAEVTVEEGKVTLAKIDMGAPRLTRAEIPMLGEGETPFIRENFLYNNHRYAFTAVSMGNPHAVIFVDDVEQAPLTTLGPVLETHEMFPERVNVEFIEILNDAEMNFRVWERGSGVTQACGTGACAAVVAAILNGKMERGKEITVHLAGGDLMIAWTEEGNVLMKGPAEVICRGVYEYKIEA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_ACIBY
Sequence: MLWTDCLTRLRQELSDNVFAMWIRPLVAEEVEGILRLYAPNPYWTRYIQENHLELISILAEQLSEGRVRQVEILVDSRPGSILSSSEQPATTTAALQTAPIPQPAKVKREPEPVANTAVSSKSSKKKLLNPQFTFSLFVEGRSNQMAAETCRKVLTQLGASQHNPLFLYGPTGLGKTHLMQAVGNALLQAKPNARVMYMTSESFVQDFVSSLQKGKVEEFKKNCRSLDLLLVDDIHLLAGKEASLVEFFYTFNALLDESKQIILTSDRYPKELTELDPRLVSRFSWGLSVGVEPPDIETRIEILLKKAENSGVDLPRNCALFIAQQVVANVRELEGALNKVVAISRFKGAPIDLDVVRESLKDVLAIRARTISVENIQRVVSEYFRIPLKELVGPKRTRIYARPRQLAMGLARELTGDSFPEIGMAFGGRDHSTVMHACEKVVSLREEDPIFDEDYKNLLRLLQS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXK_PLAFA
Sequence: MSEYDIAKNDVTYTKLDTIECDIPINEELSWRINKFVNQLRISYSTLEEFVDNFVYELKKGLEAHRKHPNLWIPHECSFKMLDSCIANIPTGQEKGTYYAIDFGGTNFRAVRASLDGKGKIKRDQETYSLKFTGSYSHEKGLLDKHATASQLFDHFAERIKYIMGEFNDLDNKEVKSVGFTFSFPCTSPSINCSILIDWTKGFETGRATNDPVEGRDVCKLMNDAFVRAAIPAKVCCVLNDAVGTLMSCAYQKGRGTPPCYIGIILGTGSNGCYYEPEWKKYKYAGKIINIEFGNFDKDLPTSPIDLVMDWYSANRSRQLFEKMISGAYLGEIVRRFMVNVLQSACSKKMWISDSFNSESGSVVLNDTSKNFEDSRKVAKAAWDMDFTDEQIYVLRKICEAVYNRSAALARGTIAAIAKRIKIIEHSKFTCGVDGSLFVKNAWYCKRLQEHLKVILADKAENLIIIPADDGSGKGAAITAAVIALNADIPQLP
What is the function of this protein?
Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.
What are the official names of this protein?
Hexokinase.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: GPMA_THEFY
Sequence: MSTLVLLRHGESVWNAEGLFTGWVDVDLSPKGEEEARRGGRLLAEAGIRPDVVHTSLLKRAIRTANIALEEAGLHWIPVKRSWRLNERHYGALQGKNKAQTRAEFGDEQFMIWRRSYDTPPPPLAEDSEFSQHNDPRYATLPPELMPRTECLADVVRRMLPYWYDAIIPDLAAGRTVLVAAHGNSLRALVKHLDNIDDKSIAGLNIPTGIPLVYELNDDFTPRKTGGEYLDPEAAKEAIEAVKNQGK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: FUMD_SPHMC
Sequence: MKEHQCRGGRASPAAPATWLARISVSRGASAIAWTFMLGATAIPVAAQTDDPKLVRHTQSGAVEGVEGDVETFLGIPFAAPPVGDLRWRPPAPPRAWAGTRDGRRFAPDCIGNERLREGSRAAGTSEDCLYLNIWSPKQVGKGGLPVMIWVYGGGFSGGSGAVPYYDGSALAQKGVVVVTFNYRAGILGFLAHPALSKESPNGVSGNYGLLDMLAAFKWVQNNIREFGGDPNRVTVFGESAGASALGLLLTSPLSESAFNQAILQSPGLARPLATLSESEANGLELGADISALRRADAGELTKIAQSRIPMSRQFTKPRPMGPILDGYVLRTLDVDAFAKGAFRKIPVLVGGNADEGRAFTDRLPVKTVLEYRAYLTEQFGDEADAWERCYPANSDADVPAAVARLFGDSQFNNGIELLSAAFAKWRTPLWRYRFTGIPGAGRRPATHGDEIPYVFANLGPSSVSMFGSLEGGAGASDIKLATEMSAAWVSFAVHGVPDQGTKSHWPRFERRGEIMTFGSQVGSGEGLGVSPSKACQPSK
What is the function of this protein?
Involved in degradation of fumonisin B1.  Catalyzes the hydrolysis of fumonisin B1 (FB1) to aminopentol (HFB1).
What are the official names of this protein?
Fumonisin B1 esterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
Protein: VP4_AQRVG
Sequence: MGNVQTSTNVYNIDGNGNTFAPSSQMASTASPAIDLKPGVLNPTGKLWQTMGTGAPSADSLVLVVDNKGEYTYLSENMRETLNKAVTDVNMWQPLFQATKSGCGPVVLANFTTISTGYVGATADDAFSNGLVSNGPFLATMHIMELQKTIAARMRDVAIWQKHLDTAMTLMTPDVSAGDVTCKWRSLLEFAQDILPLDNLCRSYPNEFYTVAAQRYPAIRPGQPDTQVALPQPHPLGEVAGSFNAPTSEVGSLVGAGAALSDAISTLASKDLDLVEADTPLPVSVFTPSLAPRTYRPAFIDPQDAAWIAQWNGDANIRIITTYQSTDYTVQLGPGPTRVIDMNAMIDAKLTLDVSGTILPFQENNDLSSAIPAFVLIQTKVPLHSVTQASDVEGITVVSAAESSAINLSVNVRGDPRFDMLHLHAMFERETIAGIPYIYGIGTFLIPSITSSSSFCNPTLMDGELTVTPLLLRETTYKGAVVDTVTPSEVMANQTSEEVASALANDAVLLVSGQLERLATVVGDVIPIASGEDDAATSAIVGRLAIEATMRARHGGDTRALPNFGQLWKRAKRAASMFASNPALALQVGVPVLADSGILSALTSGVSTAIRTGSLGKGVSDASSKLNARQSLTLARKTFFKKVEELWPSQ
What is the function of this protein?
Interacts with VP7 to form the outer icosahedral capsid with an incomplete T=13 symmetry, about 80 nm in diameter, and consisting of 200 VP4-VP7 trimers.  Myristoylated N-terminal peptide may be released in the endosome and involved in permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm (Potential).
What are the official names of this protein?
Outer capsid protein VP4.
What is the protein family that this protein belongs to?
Belongs to the aquareoviridae outer capsid VP4 protein family.
What are the subcellular locations of this protein?
Virion.
Protein: FEN1_YEAS2
Sequence: MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTELEKMKQERRLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTPFLLRHLTFSEAKKEPIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYCESIRGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNEINLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFFQVVPKTKEQLAAAAKRAQENKKLNKNKNKVTKGRR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NAR1_RABIT
Sequence: MWVPAVANLLLLSLGLLEAIQAQSHLVTRRDLFSQETPLDMAPASFDDQYVGCAAAMTAALPHLNLTEFQVNKVYADGWALASSQWRERSAWGPEWGLSTTRLPPPPAGFRDEHGVALLAYTANSPLHKEFNAAVRQAGRSRAHYLQHFSFKTLHFLLTEALQLLGRDQRMPRCRQVFRGVHGLRFRPAGPGTTVRLGGFASASLKNVAAQQFGEDTFFGIWTCLGVPIQGYSFFPGEEEVLIPPFETFQVINASRPAQGPARIYLKALGKRSSYNCEYIKEMQCKSRPCHLDNSASAQERLSTAWSLLLLLAFLAVGPFPGSPGLF
What is the function of this protein?
Has ADP-ribosyltransferase activity toward GLP1R.
What are the official names of this protein?
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ADP-ribosyltransferase C2 and C3 toxin-like 1, ARTC1, Mono(ADP-ribosyl)transferase 1.
What is the protein family that this protein belongs to?
Belongs to the Arg-specific ADP-ribosyltransferase family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
Protein: RL44_DEBHA
Sequence: MVNVPKTRRTYCKGKECRKHTQHKVTQYKAGKASLFAQGKRRYDRKQKGYGGQTKPVFHKKAKTTKKVVLRLECVVCKTKAQLSLKRCKHFELGGDKKQKGQALQF
What are the official names of this protein?
60S ribosomal protein L44.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
Protein: GLU2B_ORYSI
Sequence: MGLHTLLLLLLLRISASAAASRPPLDTLGIPPQDEAYFRGGVIRCRDGSGRFARDKLNDDFCDCPDGTDEPGTSACPEGKFYCQNAGHSPITIFSSRVNDGICDCCDGSDEYDSNVTCKNTCWEAGKAARDKLKKKVATYKSGVVIRNQEIQKAKVAFAKDEAELAKLKGEEKILQGLVDKLTEQKKLIEKAEEEERLRKEKEEKRMKEEAEKQAADEKKASDASQEVDSQENHETVQEDESKVAEHHDGHATSHDNHTPESESSVEQHDPESQDDISIKAAPADESPPEETSAAPTKEQESTPADSEGLSREELGRLVASRWTGEKVDEVSKDDKNEHEAEHDMPEHSEETHEDESDVPESAEDSYAGYHSEVEDDRHKYDDEDFSHESDDEYVDDHDEHVASYKSDDDQKGDDHSDFTASGQASWLDKIQQTVQNVLRTFNFFKTPVDLSEASRVRKEYDDASSKLSKIQSRISTLTDKLKHDFGKEKEFYYFYDQCFESKEGKYVYKVCPFKKASQVEGHSTTSLGRWDKFEESYRVMQFSNGDRCWNGPDRSLKVRLRCGLNNELNGVDEPSRCEYVAVLSTPALCDEQKLKELEQKLEASSNQRDHDEL
What is the function of this protein?
Regulatory subunit of glucosidase II.  May be required for defense response elicited by pathogen-associated molecular patterns (PAMPs) (By similarity).
What are the official names of this protein?
Glucosidase 2 subunit beta, Glucosidase II subunit beta.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: RS16_ICTPU
Sequence: MPAKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLETIEPATLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQVYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: EFNA5_MOUSE
Sequence: MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
What is the function of this protein?
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor.  This signaling event requires the activity of the Fyn tyrosine kinase.  Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization.  With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance.  May function actively to stimulate axon fasciculation.  The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.  Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
What are the official names of this protein?
Ephrin-A5, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Membrane, caveola; Lipid-anchor, GPI-anchor. Note=Compartmentalized in discrete caveolae- like membrane microdomains.
Protein: PERI_RAT
Sequence: MSHHSSGLRSSISSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPSSSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLGALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSLKTTVPEVEPPQDSHSRKMVLIRTIETRDGEKVVTESQKEQHSELDKSSIHSY
What is the function of this protein?
Class-III neuronal intermediate filament protein (PubMed:3339087, PubMed:2624740).  My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity).  Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity).  Plays a role in the development of unmyelinated sensory neurons (By similarity).  May be involved in axon elongation and axon regeneration after injury (PubMed:7530776, PubMed:2585054).  Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
What are the official names of this protein?
Peripherin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
Protein: TAF3_YEAST
Sequence: MTTNNDFYFALLRISILQLLKAQGFDRARPSLVDVMTDLYAKFLSLLASEVSSIAQARCDQDDTIALQDITLALENLGIVKPTNVLDVYDENSELSSSRGMEKFKDWCIYSTQLTDARITALPTVELLQSEEKESDPLSAIPDYLNQLLQNKGAKQKLETKNRKTELIEDLINNNGLDDWIKLVIARQRINMIERASKKESQNVPALPHIAGYKSSILSRHHHTTITNEDRMPSAMTPRDEDALTEIQENPFVTSKLPIMRKENRLENITLSFEDEELESLGEVEGPNQKSQENNNEESFKENNKSLTESPHGDDRDISMFQFDSNVDTKWAEQEDMDSTFQRRTSLDYGGYF
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 3, TAFII-47, TAFII47, TBP-associated factor 3, TBP-associated factor 47 kDa.
What is the protein family that this protein belongs to?
Belongs to the TAF3 family.
What are the subcellular locations of this protein?
Nucleus.