PharMolix/UniProtQA huggingface dataset:
Protein: FTHS2_STRP3
Sequence: MVLSDIEIANSVTMEPISKVANQLGIDEEALCLYGKYKAKIDARQLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSRRITWKRVVDMNDRQLRHIVDGLQGKVNGAPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYRGEPVTAKDLKAGGALAALLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVPKADLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACDKRGVDVVISDVWANGGAGARELAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGFGNYPICMAKTQYSFSDDAKKLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase 2, Formyltetrahydrofolate synthetase 2, FHS 2, FTHFS 2.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: DDIT3_MOUSE
Sequence: MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
What is the function of this protein?
Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15601821, PubMed:19752026).  Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15601821, PubMed:19752026).  Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (PubMed:1547942).  Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (PubMed:1547942).  Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:12706815, PubMed:15775988, PubMed:21159964, PubMed:14684614, PubMed:19919955).  Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity).  Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (PubMed:22242125, PubMed:23624402).  Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity).  Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (PubMed:16670335).  Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (PubMed:22265908).
What are the official names of this protein?
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA-damage-inducible protein GADD153.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present in the cytoplasm under non- stressed conditions and ER stress leads to its nuclear accumulation.
Protein: SO4A1_RAT
Sequence: MPQHAMGDKHFLSLPKHLFTSTSSTTDSGCDTPPSSRASPASLRSAHGALGSSSQPLFEPQVEKRSSQAACEVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETGTCLTNQSQVECKDRASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPLLLVLVFVVIIFTFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYKNEAMSRYLLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV
What is the function of this protein?
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2).  Shows a pH-sensitive substrate specificity T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment.  Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions.  May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier.
What are the official names of this protein?
Solute carrier organic anion transporter family member 4A1, Organic anion-transporting polypeptide E, OATP-E, Sodium-independent organic anion transporter E, Solute carrier family 21 member 12.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RACA_BACAA
Sequence: MEYKTPFIAKKLGVSPKAVVRIAQQLNLTIEKNKYGHFIFTQDDLDQMLEYHRSQIEQSQNTHPTQKTSSNDVEELKTQVNTIVQNISSHDFEQLAAQLNTITRRLDRMEEQMQDKANDVVTYQLLQHRREMEEMLERIQKLEAGLKKEEPIYITPDTKPTYEREKKPKRRKMIFSIFGL
What is the function of this protein?
Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore.  Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.
What are the official names of this protein?
Chromosome-anchoring protein RacA.
What is the protein family that this protein belongs to?
Belongs to the RacA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cell poles and nucleoid.
Protein: AROC_CAPSE
Sequence: MASSLSTKPFLSGSRRRSTTDGSGWSYFQTSDLRQLSNQSVQISVRRQTAPLKLVVQASGSSFGKVFQVTTYGESHGGGVGCVIDGCPPRFPISEADIQSDLDRRRPGQSRITTPRKETDTCKIYSGVADGFTTGSPIHISVPNTDQRGNDYSEMAKAYRPSHADATYDFKYGVRSVQGGGRSSARETIGRVAAGALAKKILKAYAGTEVLAYVSQAHKVVLPEGLVDHETLSLEQIESNIVRCPDSEYAEKMIAAIDAVRVKGDSVGGVVTCIMRNVPRGLGSPVFDKLEAELAKACMSLPATKGFEFGSGFSGTFLTGSEHNDEFYTDENGRIRTRTNRSGGIQGGISNGEIINMRIAFKPTSTIGKKQNTVTREREEIELIARGRHDPCVVPRAVPMVEAMVALVLLDQLMLQHAQGNLFSINPALQEPLSETVSSAAASLQGV
What is the function of this protein?
Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.
What are the official names of this protein?
Chorismate synthase, chloroplastic, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLCN7_BOVIN
Sequence: MANVSKKVSWSGRDLDDDEAAPLLRRAPRLGVPAGEAAPLLNGAGPAAARASPHSAFFRIGQLSSVELDDELLDPDMDPPHPFPREIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICAMVGILTGLVACFIDIVVEKLAGLKYRLVKDNIDRFTEHGGLSFSLLLWAALNAAFVLLGSTIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNAWDLSSPGLINFGRFDTETMVYVIHEIPIFIAMGVVGGILGAVFNALNYWLTMFRIRYVHRPCLQVVEATLVAAVTATAAFVLIYSSRDCQPLRGSSVSYPLQLFCADGEYNSMAVAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYITGAAVWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSSVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSSTASNHNGFPVVEDADGTQPARLQGLILRSQLIVLLKHKVFVERSSMGLLRRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNCNQVVGLVTRKDLARYRLGKGGLEELSLAQT
What is the function of this protein?
Slowly voltage-gated channel mediating the exchange of chloride ions against protons (By similarity).  Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity).  The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity).  The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: UL12_HCMVA
Sequence: MLLVFLGPVNSFMKGIRDVGFGKPPRILSVSRARLASNTSKACPPRQLARSWRFTVISCNHFLRDLLTDRFEG
What are the official names of this protein?
Uncharacterized protein UL12.
Protein: SPB4_CANAL
Sequence: MKSNTESLAWENLRYDLHSWIKEAISSMGYPTMTPVQASTIPLLSGNKDVVVEAVTGSGKTLSFVIPVLQKISDRLYKPDSDGDLPEPVKRGHMLSIVLSPTRELANQIQSVFNQVLQYLPEDKGTRINTQLLVGSIGNVREDLNQFLTNQPQILIGTPGRILEFLGSSQSIKTSSLEIVILDEADKLLDFSFEKDVINILKKLPKQRRTGLFSATISSAGNTIFRTGMNNPVKVQVKSKNYFGEQSNSPKSLQLSYMMINPELKITTLLTILSKYQYKKAIVYFPTCTSVKHFYQIFNKVYQQESSDEPLKFFSLHGQLNTKSRLKTLDNFTQGDINLYKHILMTTDVAARGIDIPDVDLVIQIDPPTDPNVFLHRCGRTGRANKVGRAIVMLNDNCQEEDYIGFMEVKGIFLTKQDIPTSSATKNLHENFQIKLRQYMLEDRARHELAVKSYVGFIRYYSKHIASSIFRLATLDYLGIAKMYGLLRLPKMPETKYIDNSIMPTDGWLGEIIDMDKYSYADKLQEKTRLENLENDKLKKIQDAKRRKELKIKNEAWSSKSERKENKLDRKEKLKRKREAIEKQIMEEERLNDGGNKDEEDEVVEDWKDMVRKNKKKQKKNNSIQGSFDDL
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase SPB4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MVD1_ARATH
Sequence: MAEEKWVVMVTAQTPTNIAVIKYWGKRDEVRILPINDSISVTLDPDHLCTLTTVAVSPSFDRDRMWLNGKEISLSGSRYQNCLREIRSRADDVEDKEKGIKIAKKDWEKLHLHIASHNNFPTAAGLASSAAGFACLVFALAKLMNVNEDPSQLSAIARQGSGSACRSLFGGFVKWNMGNKEDGSDSVAVQLVDDKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPVRILQMEEAIKNRDFTSFTKLTCSDSNQFHAVCMDTSPPIFYMNDTSHRIISLVEKWNRSAGTPEIAYTFDAGPNAVMIARNRKVAVELLQGLLYCFPPKPDTDMKSYVLGDTSIVKEAGLEGELPQGIKDKIGSQDQKGEVSYFICSRPGRGPVVLQDQTQALLHPQTGLPK
What is the function of this protein?
Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (PubMed:10344201, PubMed:26216978).  Is specific for (R)-5-diphosphomevalonate (MVAPP).  The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP (PubMed:26216978).  Can complement a yeast mutant defective in MVD activity (PubMed:10344201).
What are the official names of this protein?
Diphosphomevalonate decarboxylase MVD1, peroxisomal, Mevalonate 5-diphosphate decarboxylase 1, AtMDD1, AtMVD1.
What is the protein family that this protein belongs to?
Belongs to the diphosphomevalonate decarboxylase family.
Protein: ETFL_ASFK5
Sequence: MEFHNDFLTNPLRVTLYNPAENEYTKTFIFLGSVPANVLQACRKDLQRTPKDKEILQNFYGKDWEKKLSQYVVGGDSDDLDEFEKLFVEDSGEETNVMMPEIETMYSEYSIFPEDTFKDIREKIYVATGVPPYRQHIFFFQNNALQVTYRLMLSGSGVALDIRDYKKEFQQVGGLNIDATMESQKDELYVEALDSFQLIKNIHHIFVADLNTLVAPMRRQISIAIEDNYQFDLLYYGLIMKYWPLLSPDAFKLLIQSPLQMEKQYPALSPSLTSLKKRLLLEQKLINFTYARAQQVVAKYEGNKLTRGTLAVTSAMIKISPLVNIQINVRNVFDLFPATPDIPQLVVFFYSKTGPTVVSKHHITSTEPEKFSNKTFRVPTIILIRYINKKAFILTIQNNGHYFIESNWSENERHDFNSVVSTLNNFINPIIHTINDMGPAAFPRGGSLPLPSNEDIQISISSMSVSTFWPYTLSSKGFTELKSRWREYEQAGIISVRGLQQTGVYNFLFKKGIYSYDPHEIERMIIISSGPGRKMDINVALLQNTYAYLFDTNVAARWETIYGGRNIRIYHRVTDIKIEMFNITQEEFNYLWVYLFVFLDNLITGPDKIMVNKLSQLHDKQQGKGASQLRALQEQDPDLYDLRKYDTQATVYSVLCQHPRPPVIYSEAEVKSMPPAKRKELVKYWNFTEGVPAYYSCPHPDYPHLSLLEGRHPLNYCLPCCQKTKALLGTKRFYINNTCLTKHTFVEQDLEDLNTQTSRHTLSYGKKIPVNRIAFLPHQIADELFSNTIKEPDIFCIVGVEQTMLGISNAGLFYSLARILDLAPKALAVEIAKAANTPQYYILGNGAGNMFSSGAELANFILQTFVEQKNQLLQWDTAWQDIFLDLVAICYDLHCVFFKDKQGDIEFEVSPSTIQKILSPSKKIAIIFDTNEGIYPMAMTQQKRFLKNSEAQYIFTEEDPVMEVIHSMSEFMCKDGWWDIHDVKNIPGYTVTKKLINRHNFCYALLIVSDTDRPIYFPIRLSSYIHDDIPIDFDLRPTDIASFEETWKFIRLFNKHFKQYEIIPSAVLQNMKKEFVGFLSEGKTGLYFYYAPTQTLPATLEKLPIATLTIDPRDIDQAILYPLEEPYPHQDKANKAFYMNHLYKFLLIEFFDVLYGLQSNTTRKRIEDLFQKTDFQKINSVTEFYTKLSDFVDLNDIHTIKHILETTGADHALKVLQKNVFNFDYILLSPLQSYTYDELCQYLKKLLTPRIEFYEDIETIDRGLINIYTSCQYSTLKQPQCEKKRLRIPVNHFENYINILAADILNPLKHSTLLLTGLGVIDDLQFIMRPQEIISVKNKF
What is the function of this protein?
Putative initation factor.
What are the official names of this protein?
Early transcription factor large subunit homolog, VETFL homolog.
What is the protein family that this protein belongs to?
Belongs to the asfivirus G1340L family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with viral nucleoid.
Protein: CCMB_PSEAE
Sequence: MSNVFSLLLAREARLLFRRPAELANPLVFFAIVIALFPLAVGPESQLLQTLSPGLVWVAALLAVLLSLEGLFRSDFEDGSMEQWVLSPHPLALLVLAKVLAHWLFSGLALVLMSPLFALMLGLPARCIPVLLLSLLLGTPVLSLLGAVGAALTVGLKRGGLLLALLILPLYIPVLILGSGALQASLQGLPSSGHLLWLASLTALALTLTPFAIAAGLKISVGE
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein B, Cytochrome c-type biogenesis protein CcmB.
What is the protein family that this protein belongs to?
Belongs to the CcmB/CycW/HelB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH603_BRASB
Sequence: MAAKDVKFSTDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKTADLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGIDLAVDAIVADLKAHAKKITSNDEIAQVGTISANGDNEIGRFLAEAMQKVGNEGVITVEEAKSLDTELEVVEGMQFDRGYVSPYFVTNSEKMRVELEDPYILIHEKKLSGLQTMLPLLEAVVQSGKPLLIVAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTTISEDLGIKLENVTLSMLGRAKKVVIDKENTTIVDGAGAKKDIEARTQQIKLQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGVALLRATKVLDGVKTANADQKAGVDIIRRAIQVPVRQIVQNAGEDGSLVVGKLLEKDTYSWGFNAATGEYQDLVQAGVIDPAKVVRTALQDAASVASLLITTEALVADKPKKAEATQAAPAMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 3, 60 kDa chaperonin 3, Chaperonin-60 3, Cpn60 3.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_CUPPJ
Sequence: MTDSANNRPPRLPRREVHGVLLLDKPLGLSSNDALVRAKRLLRALKAGHTGTLDPLATGLLPLCFGEATKFSQDLLDADKTYEAVVRLGQKTTTGDAEGEVVVERPVSCDRAGLDAAIARFLGEIDQVPPMHSALKKDGRPLYEYARAGQTVERPARRVTIHAIDVLDCALPLAPSFTMRVKCSKGTYIRTLAEDIGEALGCGAHLTGLRRIAVGDLTLDGAVTLDQIDAQADEARPAMLAPVDALLRRCPPVTLSAEAMSRFLQGQRLAYRDLDPDSAPQEGVLARVYGGEPPKLLGVARMREGALRPERLVRL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: GSA_YERPY
Sequence: MSKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVERGLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVGVYETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFTNADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSLAHSNEDIQKTVNAARRCFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTYH_HUMAN
Sequence: MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDGMIAECPGAPAGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ
What is the function of this protein?
Involved in oxidative DNA damage repair.  Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone.  Possesses both adenine and 2-OH-A DNA glycosylase activities.
What are the official names of this protein?
Adenine DNA glycosylase, MutY homolog, hMYH.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: YHAI_ECO57
Sequence: MQWYLSVLKNYVGFSGRARRKEYWMFTLINAIVGAIINVIQLILGLELPYLSMLYLLATFLPVLALAIRRLHDTDRSGAWALLFFVPFIGWLVLLVFFCTEGTSGSNRYGNDPKFGSN
What are the official names of this protein?
Inner membrane protein YhaI.
What is the protein family that this protein belongs to?
To E.coli YhaH.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS15_HELMI
Sequence: MALDSVRKQEIIGKFKQHEKDTGSPEVQIAILTDRINYLTGHLKTHKKDHHSRRGLLKMVGQRRNLLAYLKRTDIERYRKLVTELGLRH
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SH3L2_XENTR
Sequence: MVIKVFLASSSSSVTIKKRQQEVLQFLEANRIEYEEVDITMLEEKRQWMYKNIPKDRLPEQGNPLPPQIFNDNIYCGDYESFFESKESNTVFLFLQLKSRPAQKEL
What are the official names of this protein?
SH3 domain-binding glutamic acid-rich-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SH3BGR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GRPE_CUTAK
Sequence: MTDKNVNPDDDQADENRDDNVDERFADIVGDVDIDADQSATDSPAPEELSRESQLEALLAERTEDLQRLQAEYVNYKRRVDRDRALSRQSGVDKVITDLMPVLDSIAMARQHGEVEGGFKLVVDELEKVANNHGLTSFGEVGDVFDPNLHEALMQMPMEGVSVTSVSQVMQPGYKLGDRVLRPARVAVSDPDPNATSADESSQADGESAQADEDDETPRNE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEMA_BPD10
Sequence: MSRTSLIKLIHVARRELQLDDDTYRAFLMQKTGKISCRELTVTQLEQVLDAMKERGFKKLNKYPRRRFKEHVTPREKVYKIWQQMAEDGFITDGGDVALDKYVQRLTAKRNGGQGVSTLAWCHGESLQVVLETLKQWHIRCIREAFSRHGLPLPVSPSGRELRGYDAMTAAYAHARKTRRMAQ
What is the function of this protein?
Early protein responsible for decreasing host DNA gyrase activity.  Promotes DNA relaxation of bacterial host genome.  Modulates the expression of various host genes probably controlled by supercoiling of their promoters.  Host genes affected include DNA replication and cell division determinants (By similarity).
What are the official names of this protein?
GemA protein, Gene product 16, gp16.
What is the protein family that this protein belongs to?
Belongs to the mulikevirus gemA protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: NUOK_CAMC1
Sequence: MIGLTHYLILASLVFVIGLVGIMRRRNLIMLFFSSEILLNSANIALAAISKYYFDLTGQIIAFFIVAIAASEVAVGLGLLVLWYKKTGSISLDSMTNMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KN14R_ORYSJ
Sequence: MEEEGSGRGGDGPAAHGRIGDTASLGASCVRAGVGGDSPVMVSSASVRKTVKMSETCDFIPYVDDDDDGNSEEENSASSGILPCDGMQHDTPDYIRRGAAAARHRIAPLELFSGPSPPQGPPSPSPAIGGAALEATSNDGVAEPQVHPPEGISSIISTGGGEQETATMGSQSVHETLHIEENEGKCSCCGQLKQEYSLLLREKEECRRVLEDLMRENELKSRECHEAQASLHELRMELMRKSMHVGSLAFAVEGQVKEKSRWCQLLNDLSEKFKALKAEHQILLQESLECKKFVADATQMTTTIQQHVNQYASLECEFKDLKEKFTEETKERKDLYNKLIEVKGNIRVFCRCRPLNGEEIEEGASMAVDFESAKDGELIVRGHVSSKKVFKFDSVFSPEEDQEKVFEKTVPFATSVLDGYNVCIFAYGQTGTGKTFTMEGIEDARGVNYRTLEELFRITKERQGLFQYEITVSVLEVYNEQIHDLLLTGTQPGATAKRLEVRQVAEGVHHVPGLVEARVTNMNEAWEVLQTGSKARVVGSTNANEHSSRSHCMHCVMVKGENLMNGEQTKSKLWLIDLAGSERVAKTDAQGERLKEAQNINKSLSALGDVISALATKSQHIPFRNSKLTHLLQDSLSGDSKTLMFVQISPNENDVGETLCSLNFASRVRGIELGQARKQVDVGELSRYKLMAGRAKQDSKNKDAQIKSMEETIQSLEAKNKAKDLLTMNLQEKIKELEAQLLVERKIARQHVDNKIAQDHLHQQQQSKKPENSPCPTRSPMAERNLNSTAEKPVTLLKDLGIARQMFSDSNTDTYSINHLMSMSSEKENNPAGGAQPTKARRVSLCGGAHQQPAAPPRRGSLIPLPRRNSLMLPLPLPKPATPAAAASPLDMITEQCSSPLVIAPNDIRGGGGGGGRNKRIINSILRRSLQKKVIIRPPLMAAHQSGRRAGAGVAGTTTHGGGGGGVMRARRVPVSGGRGGGGVQHNREKERGWNNGTSLRQLN
What are the official names of this protein?
Kinesin-like protein KIN-14R.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: ATTE_HYACE
Sequence: MFGKIVFLLLVALCAGVQSRYLIVSEPVYYIEHYEEPELLASSRVRRDAHGALTLNSDGTSGAVVKVPFAGNDKNIVSAIGSVDLTDRQKLGAATAGVALDNINGHGLSLTDTHIPGFGDKMTAAGKVNVFHNDNHDITAKAFATRNMPDIANVPNFNTVGGGIDYMFKDKIGASASAAHTDFINRNDYSLDGKLNLFKTPDTSIDFNAGFKKFDTPFMKSSWEPNFGFSLSKYF
What is the function of this protein?
Hemolymph antibacterial protein.
What are the official names of this protein?
Attacin-E, Immune protein P5.
What is the protein family that this protein belongs to?
Belongs to the attacin/sarcotoxin-2 family.
What are the subcellular locations of this protein?
Secreted.