PharMolix/UniProtQA huggingface dataset:
Protein: MED8_NEUCR
Sequence: MADGKDSLRLAPDEFKQLEVLRNRFHQLTHSLNSLFNDIQRSQPLPSQESLTASAAILQKSLETIQKLADENSDLFQRIVVHPSTNFPGRTQEHILLQLLRKKLEPEVESWVEDARSVAKASGLDPSKLASSQQRSNDYDDDDDDYRDEEEDAPSDPFNEQWADMFQVSMDSIRDYLMNQANEPYTIAEREMGIENVRTGLKRSLEEEDSEEEDEDEDEDEDRSLATAGLGNINAANLFHPEHVLWLASRGNMKVPKNVDLEAIRKREKPRGRPAPAQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAUF_METEA
Sequence: MPTLTPPAGSEVIPFASVHTERVEDCLVFPSELSTKVRLGGLVTAVSGGILGAALLSQTSSQGVAVPALLMGLSFVGGLLSTWSPCGYSSLCLLRPVGPYSARSLVKYTPTFLLHGIGYAVGALILGCVLGIAGGLLGFGGVSFGALAGLGAAGIIYGAHQLGFLRVPYPQRRAQVPHDARQRFPVWFIGGLYGLSLGLNYLTYVQTPILYLVTAAAVLSSNIGAAILLFAAFNAGRFLPMAVNYLPVSDITVQNWLARRQEGAALLDGVLLVAGGAALLTFAAL
What are the official names of this protein?
Methylamine utilization protein MauF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METK_SHELP
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVMVGGEVTTSAWVDIEELTRKTVREIGYTHSDMGFDADSCAVLNAIGKQSPDINQGVDRADPKEQGAGDQGLMFGYASNETDVLMPAPITYAHALVKRQSEVRKDNTLPWLRPDAKSQVTFAYEDNKIVGIDAVVLSTQHCDSVSQSDLIEGVMETIIKPVLPAQWLNKETKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSISVETFGTGKVSEEVLIGLVRQHFDLRPYGLTEMLDLARPIYKATAAYGHFGRNEFPWERTDKAEALRADAKL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI_MYCBO
Sequence: MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLSGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
Probable DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: MUTL_SALCH
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEEIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQTAGGWPHAQPGYQKQQGEVYRALLQTPTTSPVPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQQAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: Y586_METJA
Sequence: MRDSIMQMCELCGKLTDKLYKVIIEGSEMNVCKECAKFGKSPKTYSRLGKKTIIGKGTITTNKQVKKPIKRRRDIFDTLPMLREDYGDVIREAREKRGLSIEELAKKLKMKASTLQKFERYELEPNEKEIKILEKELKISLTESIGEETSYYGGRDEDGFTLGDFIKIKK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator MJ0586.
Protein: COAD_ECOBW
Sequence: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVALAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBFA_DICDI
Sequence: MEELIKAPNSNFIIMSNQPYQTTSPEIVEDYIIKRGQPFVLTGTTQGWSRSNMFTLDFLSERYSEMELINSPRNNETHTDLQGWRMKDFISYLQVSPEERNPKHLYGKDIACPREWQEYLSHKLQPQYSYKSRFDLVSHLPDYLQPETLLVYIGSNGTYTPGHIDMCGSLSQNLMVSSDQDAFAWWFIVPTEYKDEALKFWGDKGGDVYNESRFIRPIDLLGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAWNSISLKSLPISYFSSLPHTRRMAKPELFRIKAIAYYTLRKIMGDVENTNFNTIDVNDVIDIIAPLLEIFHNILQTESILIPKPNYPYCNGETIPFLQPFKYFNGDRIQDRRCDHCNSDIFNRCYHCETCKTDDGQGKDFCFDCVSSGIGCEFHFKVMVLKEFISHSKLKKELSSFYEIYKNLLAHSGRRPKEVDDIITKSTDRVSDECGFLTTATVAYHVVFYSSQKKIKCHRCEKRFKKFSIIFCTNCNARFCEQCVVNTFGQNFQVLMKRNEWECFCCKGLCDCSNCTSNSNSSNHPRILNNNQQLGLPYNNNNNSNNNNNNNINNNNNNNNNNINNNNNNMNNNNSINNNNNNNNNNNINNNNINNNNHHNNNGNNNLNSSYSSLNALSSLSQQQSYGSYDNYNNNNNNNNYNNNNNNNGHIQILKSGRQYDDEQSSSSGSGSSNSTPTKPRPRNGGDDGLMSHFSGNNNNNNNHHNNNNNNNNNHHMMSHHHHNNNNNNNNNNNPTTSSLSSLSTSLSSSSTSTQKPMDVHSKKRPIVLDNDKPKGRPPKNLKEWTSTHKFIISLIELFRSSNNAILGKPNPHYKPIENLPPLVQLYLSQRKAFGGVLWAKTNSCPLLPCIWVKDLSVIPPNTKLLPSLIQGKKIVVLFFGDQDQEEYVGIVGKKSIFSFDEVNQTLLLKCGEVPLAQLEDLFNTTEPEIAMKKDIAAFNYKNQIEEKEEGLYVKQELYNNKKII
What is the function of this protein?
Transcriptional regulator involved in phagocytosis and pinocytosis.  Both activates and represses transcription.  Regulates expression of acaA, carA, pkaC, csaA, cotB and lagC (PubMed:11162086, PubMed:15470262, PubMed:16607013, PubMed:19343174, PubMed:23355006, PubMed:26339297).  Promotes amplification of the tRNA gene-associated retrotransposon TRE5-A, a mobile genetic element formerly called as Dictyostelium repetitive element (DRE).  Suppresses agnC and agnE encoding argonaute proteins which are part of a RNA interference pathway controlling TRE5-A amplification.  Required for amplification of both sense and antisense RNA transcripts, but does not activate their promoters found in A-module and C-module of the TRE5-A, respectively (PubMed:21076008, PubMed:26339297).  Nevertheless, binds to distinct DNA sequences containing A and T stretches within the C-module in vitro (PubMed:10491202, PubMed:8898890, PubMed:11162086).
What are the official names of this protein?
C-module-binding factor A.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATB_BRUC2
Sequence: MSIIDTRTPEPKRFISGATGDWEVVIGMEVHAQVTSESKLFSGASTAFGAEPNSNVSLVDAAMPGMLPVINLECVRQAVRTGIGLNAQINLKSVFDRKNYFYPDLPQGYQISQFKQPIVGEGKIMISVGPDNKGQFEDVEIGIERLHLEQDAGKSMHDQHPTMSYVDLNRSGVALMEIVSKPDLRSSDEARAYLTKLRTIVRYLGTCDGNMDEGSMRADVNVSVRRPGGEFGTRCEIKNVNSIRFVGQAIEYEARRQIAILEDGGVIDQETRLFDPVKGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAFVDALAAKLPELPDVKKQRLVETLGISVYDASILVTEKAIADYYEAVAEGRDGKAAANWVINDLLGALNKAGKDIEESPISPAQLGAIIDLIKEGTISGKIAKDLFEIVWNEGGDPKKLVEERGMKQVTDTGAIEKAVDDVIAANPDKVEQAKAKPTLAGWFVGQVMKATGGKANPQAVNELVKSKLGIEE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RT23_HUMAN
Sequence: MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREPVFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP
What are the official names of this protein?
28S ribosomal protein S23, mitochondrial, MRP-S23, S23mt, Mitochondrial small ribosomal subunit protein mS23.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FTSK_COREF
Sequence: MTRSLGDLARGRGDDADDFDDFDDFEEEISTKPKARATTRRSTRASTEDVYEEDGTDSPPRTSSWGRAGTFMDEHADGIALTLVGIAIVLGAAVWLGVGGPVGTFIADIVHLTIGAGAWVLPVALIAAAVALMLNYTPDPQSRTRVGIGGSIILLCMLGLIHLFAGNPAEWAGRKNAGGAIGAWVGTPLELGFSVYLAVPILFLILFYGALKTTGITIREFGGFVTGFFGFGAGAEDDDEEGDDLYGHVDREIETRASGRALPAAEPRPTRVTPRRTTSSTPRRAAASLDRYPADEPGTPPGPPPSVAPTGSRERKQTEASTSIEPALFPEPERRKPSVSETDEFPAVKAPETPAAEAPAPAKDSARDAVAASRENLRQAMIQRSGMDPQGPPKEEPEDNPGVVVSDGDSTYVLPSADLLIPGAPAKTHSETNDRIIEAITDVFREFNVDAAVTGFSRGPTVTRYEIELGPGVKVSKITNLQSNIAYAVATENVRLLTPIPGKSAVGIEVPNADREMVRLGDVLNAPATVDNLDPMLVGLGKDIEGDFVSYSVQKMPHLLVAGSTGSGKSAFVNSLLVSLLTRATPEEVRLILVDPKMVELTPYEGIPHLITPIITQPKKAAAALQWLVEEMEQRYMDMKQTRVRHIKDFNRKIKSGEIETPLGSKREYRAYPYIICVVDELADLMMTAPKEIEESIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQGGAEKLIGMGDALFIPQGAGKPQRIQGAFVTDEEIQAVVEAAKVQAEPDYTDGVTEDKGGDSKKIDADIGDDLDDLLEAVELVVTSQIGSTSMLQRKLRIGFAKAGRLMDLMETRGVVGPSEGSKAREVLVKPEELDTILWMLKGADPADAPKEEQWGDDGYAEPVGEGPGDGSDDSSSSDGTTVVRANPAGGVF
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: OTC_SYNP6
Sequence: MGLAGRDLLTLADLSSAEVLEILELAATLKSGQTTVHCPKTLGLIFSKSSTRTRVSFSAAIMQMGGQVLDLNPNVTQVGRGEPIADTARVLSRYLDALAIRTFAQQDLEEYAHYADIPVINALTDDYHPCQILADLQTIQENFGQWQDLTLTYLGDGNNVAHSLLLGCAQVGMNVRIACPPDYQPQERIVAKAQQIAGDRAKVEILHDPIAASQGAHVLYTDVWASMGQEEEAQARVKAFTPYQLNQALLEKADPAAIVLHCLPAHREEEITAEVLEGSQSRVWDQAENRLHAQKAVLALLLGAI
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB1_MOUSE
Sequence: MVHLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain, Hemoglobin beta-major chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: YR347_MIMIV
Sequence: MSTVADTMQTLSNDIQLTFEELIKLLLRKTLKPILNPLGNNNIVYNSIKGKYERGLVNSANNDNINRYTYTMTKESLGWTDEILAHFRINAKFIKSSVPQRFPSNTKYHNMMKPNAKISFSDKETKNIINQCGENAICQYKNLLSMLNTRNVTGILANKKATFNYSSDIPYTYTFKELEDIGKDIIDQTDPSIPGCDSARMSTAMLRVRLYNLEQNLAKLSVDKPDIFDAYIDMLRIINGVPRKKIVWVIKLIALLTYQRWEDLDKQKHQKYYEILGDDFVNSFNSNELITILLQSNSSEYIIKASLLFPLLKMLFIVFGYSKLVPVISDINAEAQAAEHERLRKFYDKYKGATIRRQSDDQNKFYETECAENNFNADHAIKQIYGKADPEPIDQCVYDFIRLFGDLYPTLIGLMGGTEKFPPESIEINCNEIPHSYEDLTIIPEFLWRFNDFSYCRYLEYICSKQLHNVLNYKVNEKTRYLQSI
What are the official names of this protein?
Uncharacterized protein R347.
What are the subcellular locations of this protein?
Virion.
Protein: ARP6_SCHPO
Sequence: MGLPPKTIVLDNGAYHIKAGFAGGKVVEIPNCLTRSKDGNRLFLGNELANCNDFTTLQFRRAHEKGYLVHWSTETAVWDLVMRNVGVMEPSMADYSLLLTQPVFTMPSIEHNTIQLVFEEFQFDAYLPCTPAELIPWDHGSFTMNQEDAYTGQHGECVLVIDSGYSFTHIIPVIDFSVQEQAVKRVDVGGKLLTNYLKEVISYRKYNMMEETYIVNEIKESVCYVSQNFKEDMEICHEKPRSKLEICYALPDYSTGKHGYIVRDINQKIEQQVLNLSNERFMIPELLFSPSDIEIREAGIPEAVMQSVTHFPENIQAMLLENVVTIGGNCKFPGFHKRLSSELRSLAPANWEVKVFEPSDPICFPWKKASHMPLEHWNANKITRSEYSEHGANIMTRKRRI
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Actin-like protein arp6.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RECF_LIGS1
Sequence: MYLEKLELKHFRNYEDVNVAFSPQVNVLIGKNAQGKTNLLESIYVLAMARSHRTSNDREMVTFKKDAALIRGEVHQRLGNTKLELLISRKGKKAKVNHLEKARLSQYIGQLNVILFAPEDLALVKGAPSVRRRFIDMEFGQIDALYLHTLTEYRAVLRQRNKYLKELQTKKATDKVYLEILSEQLSESGSQIIFKRLEFLQELEKYADKLHNQITQGKEHLQFQYESTLKEYQGKSVLELKQSLIEQYKTMMDKEIFQGTTLLGPHRDDVRFMLNDKNVQVYGSQGQQRTAALSVKLAEIDLMKEKTHEYPILLLDDVLSELDGARQTHLLKTIQNKVQTFLTTPGLSDVAQQLINKPKIFRIDNGKITEENSFTIEEE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y052_ARCFU
Sequence: MAVSIEEFSRIIIATLDLNFQILENFFTLLVVSATNSSLVSQGANLNFSNVWGLIYGGLVSNYWNSFAIHEVLNATQHNVSAMKNFSIAINYLGSNATTVFGDAEGTKGVTYLQKGIYDYLKSNPQEAENLASSLSRMFKAEVEFLIKLMGAVNTTFT
What are the official names of this protein?
Uncharacterized protein AF_0052.
Protein: VILI_CHICK
Sequence: MVELSKKVTGKLDKTTPGIQIWRIENMEMVPVPTKSYGNFYEGDCYVLLSTRKTGSGFSYNIHYWLGKNSSQDEQGAAAIYTTQMDEYLGSVAVQHREVQGHESETFRAYFKQGLIYKQGGVASGMKHVETNTYNVQRLLHVKGKKNVVAAEVEMSWKSFNLGDVFLLDLGQLIIQWNGPESNRAERLRAMTLAKDIRDRERAGRAKVGVVEGENEAASPELMQALTHVLGEKKNIKAATPDEQVHQALNSALKLYHVSDASGNLVIQEVAIRPLTQDMLQHEDCYILDQAGLKIFVWKGKNANKEEKQQAMSRALGFIKAKNYLASTSVETENDGSESAVFRQLFQKWTVPNQTSGLGKTHTVGKVAKVEQVKFDATTMHVKPEVAAQQKMVDDGSGEAEVWRVENQELVPVEKRWLGHFYGGDCYLVLYTYYVGPKVNRIIYIWQGRHASTDELAASAYQAVFLDQKYNNEPVQVRVTMGKEPAHLMAIFKGKMVVYENGSSRAGGTEPASSTRLFHVHGTNEYNTKAFEVPVRAASLNSNDVFVLKTPSSCYLWYGKGCSGDEREMGKMVADIISKTEKPVVAEGQEPPEFWVALGGKTSYANSKRLQEENPSVPPRLFECSNKTGRFLATEIVDFTQDDLDENDVYLLDTWDQIFFWIGKGANESEKEAAAETAQEYLRSHPGSRDLDTPIIVVKQGFEPPTFTGWFMAWDPLCWSDRKSYDELKAELGDNASIGQLVSGLTSKNEVFTATTTLVPTKLETFPLDVLVNTAAEDLPRGVDPSRKENHLSDEDFKAVFGMTRSAFANLPLWKQQNLKKEKGLF
What is the function of this protein?
Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments.  Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing.  Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2.  Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities.  Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity.  Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis.  Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium.  Appears to regulate cell death by maintaining mitochondrial integrity.  Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity).  Its actin-bundling activity is inhibited by tropomyosin.
What are the official names of this protein?
Villin-1.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, microvillus. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, filopodium tip. Cell projection, filopodium.
Protein: CDC48_SCHPO
Sequence: MNAPSTMTDKKPEVEHLQGENPPKDTYSAEDTATAILRKKRKPNSLVVDDATNDDNSVITLSSNTMETLQLFRGDTVVVKGKRRKDTVLIVLTDEEMEDGVARINRVVRNNLRVRLGDIVTINPCPDIKYAERISVLPLADTVEGLTGSLFDVYLKPYFVEAYRPIRKGDLFVVRGSMRQVEFKVVDVAPDEFGIVSQDTIIHWEGEPINREDEESSLAEVGYDDIGGCRRQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDVGIPDPTGRLEILRIHTKNMKLADDVDLEQIAAETHGYVGSDLASLCSEAAMQQIREKMDMIDLDEDEIDAEVLDSLGVTMDNFRFALGSSNPSALRETVVEVPNVRWEDIGGLEEVKRELRETVQMPVMYAEKFLRFGVTPSKGVLFFGPPGTGKTLLAKAIANECSANFISVKGPELLSMWFGESESNVRDIFDKARAAAPCVVFLDELDSIAKARGASAGDSGGGDRVVNQLLTEMDGVNSKKNVFVIGATNRPDQIDPALMRPGRLDQLIYVPLPDEEARFSILQTQLRHTPVAEDVDLRAVAKATHGFSGADLEFVVQRAVKLAIKDSIEEDIKRENETGEAPADDVVMDEDASVSQVQRHHVEEAMKMARRSVSDAEVRRYEAYAHQLLTSRGLTGFQFDSADSNTNGPSFGNDGADDLYA
What is the function of this protein?
ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates.  By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway.  Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER.  Involved in spindle disassembly.  Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.  CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.  Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation.
What are the official names of this protein?
Cell division cycle protein 48, Transitional endoplasmic reticulum ATPase homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: T170A_XENLA
Sequence: MEGGGGGLGGEPGLLQQILSLRLVPRVGNVTDCQRATLCSFPEMWYGVFLWALVSSLFFHIPAGLLALFTLRHHKYGRFMSVGIFLMGVLGPISAGILTSAAIAGVYKAAGKEMIPFEALVLGVGQTFCVLIVSFLRILATL
What is the function of this protein?
May regulate membrane morphogenesis in the endoplasmic reticulum (ER) by promoting ER sheet formation at the expense of ER tubules.
What are the official names of this protein?
Transmembrane protein 170A.
What is the protein family that this protein belongs to?
Belongs to the TMEM170 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Protein: SYY2_STRT1
Sequence: MKLFEDLQWRGLVKQYSSDSLIEKLNNGKLTFYIGTDPTADSLHLGHYSSFLIAKRLAKYGHQPIILIGGATALVGDPRGTSERDLAEQEKIFDNFEKLKNQIQKIFPYEIVNNYDWTKNIMAIDFLREFGKHITAGYMSNKELVKRQFATGISFTEFSYMLLQGMDFYHLFTTKGVTLQIAGSDQWGNMTTGIDLVRKKTGEEVFAMTMPLITDEEGKKFGKSEGNAIWISENKNTPEELHNFLLNVSDDIVISLLKKLTFLSRKDIEEIESRHKNGTGYAQGILADTVTFDIHGVSINKK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 2, Tyrosyl-tRNA synthetase 2, TyrRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG045_RABPU
Sequence: MLSMFMYNNIVDYVDDIDNGIVQDIEDEASNNVDHDYVYPLPENMVYRFDKSTNILDYLSTERDHVMMAVRYYMSKQRLDDLYRQLPTKTRSYIDIINIYCDKVSNDYNRDMNIIHDMASTESFTVYDINNEVNTMLMDNKGLGVRLATISFITELGRRCMNPVETIKMFTLLSHTICDDCFVDYITDISTPRDNATTNSSTREYLKLMGIAVIMFATYKTLKYMIG
What is the function of this protein?
Plays a role in evading host innate immune response by inhibiting host inflammasome activation.  Interacts with and inhibits NLR-mediated interleukin-1 beta/IL1B production in infected cells.  At the host mitochondria outer membrane, interacts with the BH3 domain of host BAK and prevents BAK from binding active BAX.  In turn, host apoptosis is inhibited.
What are the official names of this protein?
Apoptosis regulator OPG045, Protein F1.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG045 family.
Protein: LOLA_SERP5
Sequence: MKKLLVACCLLSGFASTSVLADAAQDLQSRLAKVNSFHASFSQTVTSSDGAAVQQGEGELWVKRPNLFNWHMTSPDESVLVSDGQTLWFYNPFVEQVTATWLKNATGNTPFMLITRNNANDWKQYNVKQKGNDFELTPKSSSGNLKQFAISVDNSGTIRNFAAVEQDGQRSSYTLKSQQNVAADASKFKFTPPKGVTLDDQRQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLYA_HAEI8
Sequence: MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYLNPLPHAHVVTTTTHKTLGGPRGGLILSSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYPK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.