PharMolix/UniProtQA huggingface dataset:
Protein: FOLD_BURCM
Sequence: MTALLIDGNALSKTLRTQAAQRAAALTARGHQPGLAVVLVGANPASEVYVRNKIKACEDNGFFSHKDAYPDTLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVLEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHDIPLQGANAVVIGRSNIVGKPMAMMLLEAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGHITPVPGGVGPMTITMLLINTIEAAERAAAAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: AMPPA_METM5
Sequence: MLFLNAKFIDLDLGENAVIVNEEDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVNKGEVGMLVSELAEISISEGEEVKLRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLSNIELSAFVSSTYINGMNMDEISEMTKRIAETGDMIAWEKSLVVDIHSIGGVPGNKYALLSIPILAAAGITVPKTSSRAITSPAGTADVMEVLTNVELKEEEIKRIVKTTNGCLAWGGGVNLAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYTVIDIPVGKGVKIKNEAEGAKLARKFIELGESLNIKVECVLTYGGQPLGRAIGPALEAREAIEALQDPKNAPKSLIEKALSLAGILLELGGAAQIGEGQNLAWEILESGKALEKFNQIITEQGGTPKKPEEIELGDYVEEILAPIDGYITDISNTAITNVVKEAGAPRDKKAGILLNSKIGNKVKQGDVLYTIYSGSEERLVSAINLARRVYPVKVEGMLIERISKF
What is the function of this protein?
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P).  Exhibits phosphorylase activity toward CMP and UMP in addition to AMP.  Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
What are the official names of this protein?
AMP phosphorylase, AMPpase, Nucleoside monophosphate phosphorylase, NMP phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: SSU72_YEAST
Sequence: MPSHRNSNLKFCTVCASNNNRSMESHKVLQEAGYNVSSYGTGSAVRLPGLSIDKPNVYSFGTPYNDIYNDLLSQSADRYKSNGLLQMLDRNRRLKKAPEKWQESTKVFDFVFTCEERCFDAVCEDLMNRGGKLNKIVHVINVDIKDDDENAKIGSKAILELADMLNDKIEQCEKDDIPFEDCIMDILTEWQSSHSQLPSLYAPSYY
What is the function of this protein?
Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72, CTD phosphatase SSU72, Suppressor of SUA7 protein 2.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCR1_YARLI
Sequence: MLVPWAPIAATSVVAAAASSYYFSNMAISNDAKTATLKGDDQWVDLKLKSSKDLSHNTKALIFELPTPDSTLGLTTASALLTKYVTPKGSNVVRPYTPVSDPDSKGEFELVVKSYPEGKMSKHIHELKEGDTLSFKGPIIKYQWQPNLHKEITLIGAGTGITPLYQLISAINKNPEDKTKVNLFYGNATEGDILLKDEIDAIAKAKPQQFNVHYFLDKPSDNWKGENGFISEEFIKGNSPAADSDNVKVFVCGPPPFYKAISGAKVSPTDQGEVDGALKNLGFNKDQVFKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: HUTH_BURA4
Sequence: MITLTPGHLTLPQLRKIAREPVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDALITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIHELRGHRGQIEAAAAYRDLLDGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATFAARKLADIADNTKYILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRSHVAHYELDHYFAPDIAVIAKLVGERAFAKAAPFSFASEQ
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPQ_YERPE
Sequence: METLASLYNEHLSTLQQRTRDVLERHQLDALLIHSGELQRLFLDDRDYPFKVNPQFKAWVPVTEVPNCWLWVDGVNTPKLWFYSPVDYWHSVEPLPDSFWTKNIDVQPLLNADDIAQQLPVQRERVAYIGYAQQRAQALGFSAENINPQPVLDYLHYYRSYKTDYELACMREAQKTAVVGHRAAYEAFQSGMSEFDINLAYLMATGHRDTDVPYDNIVALNEHSAVLHYTILQHQPPAEIRSFLIDAGAEYNGYAADLTRTYTADRDSDFAALISDLNTEQLALIDTIKSGERYTDYHVQMHQRIAKLLRTHNLVTGISEEAMVEQGITCPFLPHGLGHPLGLQVHDTAGFMQDDKGTNLNAPSKYPYLRCTRVLQPRMVLTIEPGLYFIDSLLAPWRIGEFSKHFNWDRIDALKPYGGIRIEDNIVIHDKRVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: SCRY_SALTM
Sequence: MYRKSTLAMLIALLTSAASAHAQTDISTIEARLNALEKRLQEAENRAQTAENRAGAAEKKVQQLTAQQQKNQNSTQEVAQRTARLEKKADDKSGFEFHGYARSGVIMNDSGASTKSGAYITPAGETGGAIGRLGNQADTYVEMNLEHKQTLDNGATTRFKVMVADGQTSYNDWTASTSDLNVRQAFVELGNLPTFAGPFKGSTLWAGKRFDRDNFDIHWIDSDVVFLAGTGGGIYDVKWNDGLRSNFSLYGRNFGDIDDSSNSVQNYILTMNHFAGPLQMMVSGLRAKDNDERKDSNGNLAKGDAANTGVHALLGLHNDSFYGLRDGSSKTALLYGHGLGAEVKGIGSDGALRPGADTWRIASYGTTPLSENWSVAPAMLAQRSKDRYADGDSYQWATFNLRLIQAINQNFALAYEGSYQYMDLKPEGYNDRQAVNGSFYKLTFAPTFKVGSIGDFFSRPEIRFYTSWMDWSKKLNNYASDDALGSDGFNSGGEWSFGVQMETWF
What is the function of this protein?
Porin for sucrose uptake.
What are the official names of this protein?
Sucrose porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: NSRR_PECAS
Sequence: MQLTSFTDYGLRALIYMASLPSGKMTSISEVTEVYGVSRNHMVKIINQLSRAGLVMAVRGKNGGIRLGKPAETIRIGDVVRELEPLTLVNCSHEFCHITAACRLKQVLQQAVQNFLHELDQYTLADMVKENPPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: CFD1_CRYNB
Sequence: MADIIETPVSRRLSTVKNIIIVLSGKGGVGKSSSSVQLALSLLAQSPTNRVGLIDLDITGPSLPRMVGLDTPTATVHQSSAGWVPVYVDQGRRLGVMSIGFLLKDRGDSVVWRGPKKDGMIRQFLSEVRWGDLDYLVIDTPPGTSDEHISLLTHLHPLFTPTMSNATTPTSILISTPQTTALNDTLKSLSFTRKLSLPVMGLVENMAGYVCPCCGEISDTFGKGGGEAMAHKEGVGFLGRVPIDTVLVSLLDAVSKGEVLGEGAVEHTSDEAAEGQTNGSTEHFPLLDKYLETTSSKVWKDITQKLVDKIEQHKSDIRARLESSSETLAIA
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor CFD1, Cytosolic Fe-S cluster-deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE7_HPV60
Sequence: MIGNQPNVNNLDVNLEELVLPVSLLADEELSPDGDPEEEEHYPYTIDTCCKPCGAGVRFTIIATPSAVITLRQLLLQEVFLTCLRCSRSLFRHGRS
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: RECO_COXBN
Sequence: MTKRVALEPAFILHRRPYSNTSLILELLTPNHGRVCALARSARGLKSRYKGKLELFSPLLISWSGRSDLKFLGDVEANGMPYLLEGEALLCGFYLNELLIRLLHHDDPYLRLFHHYQNTLEKLVNGRLEATLRCFEKQLLDELGYGLPLSCDVEMKLPFKPDQFYQYLPDRGFLLCEKSEERDVFSGKSLLALQEESFSDESSLKEIKYLMRLTLNRLLGKKPLKTRELLF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: YKM1_TRYBB
Sequence: MGVQISPYTNPVLFWGVFEVRGTSKGVGVILTRFFLEIFMILVFVGFETRCLW
What are the official names of this protein?
Uncharacterized kinetoplast minicircle 201 polypeptide.
What are the subcellular locations of this protein?
Mitochondrion matrix, kinetoplast.
Protein: RL17_BIFLS
Sequence: MPTPKKGPRLASSPAHERLMLANMATSLFQNGRITTTLPKAKRLRPLAERLITFAKRGDLHSRRRVMRVIRNKSVVHILFTQIAEQMEQREGGYTRIVKIAPRVGDAAPAAVIELVTEPVAKKAVVKEAEAAAKVAEEEAPAVEAEATEATEAPVEEAAAVEAEAPADAEKAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SYD_HAEI8
Sequence: MMRTHYCGALNRNNIGQDVTLSGWVHRRRDLGGLIFIDMRDRDGIVQVCFDPKYQDALTAAAGLRNEFCIQIKGEVIARPENQINKNMATGEVEVLAKELRIYNASDVLPLDFNQNNTEEQRLKYRYLDLRRPEMAQRLKTRAKITSFVRRFMDDNGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFLTAPEVREIMERMVHDLWLDTIGVDLGKFPVMTWQEAMRRFGSDKPDLRNPLEMVDVADIVKDVEFKVFNEPANNPNGRVAVIRVPNGAEITRKQIDEYTQFVGIYGAKGLAWAKVNDINAGLEGVQSPIAKFLNEEVWKALAERVNAQTGDILFFGADKWQTTTDAMGALRLKLGCDLGLTRLDEWQPLWVIDFPMFERDEEGNLAAMHHPFTSPKDFSPEQLEADPTSAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFRILGIDEEQQREKFGFLLDALKFGTPPHAGLAFGLDRLTMLLTGTENIRDVIAFPKTTAAACLMTEAPSFVNPQALEELAISVVKAE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB119_ARATH
Sequence: MATVDVINGDSISTLHSDIIQTQILTRLDGPTLASTATTSSYLQTLCTEEKLWQELSIDTWPSINDPRVVQAISSFPSGYRSFFADSYPFTEHTWQSEKHDPPTGLISAVDLYYRGEIIYSKVQEMETEKGKSGWFLSSPFRVDILDPKESVQTRIRYPGGDYEAWVKDMEESMKLNWILIDPIKKRAANISSRKAVSARRNWLTGDLEIRFSTVVTAEAAEVAAVVSCGSAEAWKEVDEEVGGEIHVRDVRLQVEDIEGKCMKGRDSLVILQGLLDGKRSCKDDEERRAKERYEEYVRMKIQWRENKERREKAQDTICMIFGFSMFVLLWSFILLR
What are the official names of this protein?
F-box protein At2g27310.
Protein: RL31B_STAA9
Sequence: MKQGIHPEYHQVIFLDTTTNFKFLSGSTKTSSEMMEWEDGKEYPVIRLDISSDSHPFYTGRQKFAAADGRVERFNKKFGLKSNN
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: SPT22_MOUSE
Sequence: MKRNLNESSARSTAGCLPVPLFNQKKRNRQPLTSNPLQNDPGVSTVSDSYGSPSFPTDWAWEAVNPEVAPLKKTVNTGQIPASASYPWRSQDSVSKSIQSNAERSQSAWGYRGNNRNTSLRTWDFRPQHKTVSPAANSEFSSCPVNLGAQQQKQFQTPEFPNLPGHKEAEVPRQTCLSKLPGSTMKGPDRASALQAFKPSFQQNPFKKTVLGDIPRENSLKEGTLHQLKEKDNSLRIISAVIESMKYWRAHVQKTVLLFEILAVLDSAVTSGPHYSKTFLMRDGKNILPCVFYEIDRELPRLIRGRVHRCVGHYDPDKNIFKCVSVRPASASEQKTFQAFVTIADAEMKYHTKVTNEM
What is the function of this protein?
Meiosis-specific protein required for homologous recombination in meiosis I.
What are the official names of this protein?
Spermatogenesis-associated protein 22.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB.
Protein: RL25_CAMJD
Sequence: MLEGIVRESIGRKAAKALKRDGYLIANIYGKGLENINAAFKVNEFIKEVRKKTTLIFDVKVGSQTLSVVVVDYQKDPVTAELKHVDLKVAQKGVISKYMVPVKITGTAIGLKNKGVLIQSKRRLKVKCAAENLPNFFELDVSKLDVGDALLVRDIVVPAGVTMIDADRVAVVGVEKAR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL32_ALIFM
Sequence: MAVQKSKKSRSMRGMRRSHDALTTSAVSVDATSGETHLRHNVTADGYYRGRKVINK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LIS1_CHICK
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSTISEATGSETKKSGKPGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDFKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation.  Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity).  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  May be required for proliferation of neuronal precursors and neuronal migration.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: RS28_PYRIL
Sequence: MSSEVKFSPYEDAVAALVIQILGRTGVAGEVTQVKVKILEGRDKGRILTRNIKGPVRLGDIVMLRETEREARRITAR
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: SPY3_HUMAN
Sequence: MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSLIVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV
What is the function of this protein?
Inhibits neurite branching, arbor length and neurite complexity (By similarity).  Inhibits EGF-mediated p42/44 ERK signaling (By similarity).  Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395).  May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049).
What are the official names of this protein?
Protein sprouty homolog 3, Spry-3, Sprouty RTK signaling antagonist 3, Sprouty3.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQSA_ECOLI
Sequence: MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKKLSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity.  Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation.  Initially reported to act as a cotranscription factor with MqsA (PubMed:19690171, PubMed:20105222).  Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA.  Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA-repressed transcripts (PubMed:23172222).  MqsA binds to 2 palindromes in the promoter region of the mqsRA operon activating its transcription.  Binds to other promoters, inducing mcbR and spy and repressing cspD among others (PubMed:20105222).  Binds to and represses the rpoS promoter, the master stress regulator, resulting in decreased cyclic-di-GMP, reduced stress resistance, increased cell motility and decreased biofilm formation; in these experiments 5 TA systems are missing (lacks MazEF, RelEB, ChpB, YoeB-YefM, YafQ-DinJ) (PubMed:21516113).  An earlier study showed overexpression alone increases biofilm formation, perhaps by repressing cspD; in these experiments the 5 TA systems are present (PubMed:20105222).  Represses the csgD promoter.  In the presence of stress, when this protein is degraded, the promoters it represses are derepressed, leading to biofilm formation (Probable).  This TA system mediates cell growth during bile acid deoxycholate stress by degrading mRNA for probable deoxycholate-binding protein YgiS; bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum (PubMed:25534751).
What are the official names of this protein?
Antitoxin MqsA.
Protein: ANMK_BRADU
Sequence: MMLTALGLMSGTSLDGVDVALIETDGKQVKAFGPSGYRPYSPVERNLLRQALSEAVHLTRRDARPGILAEAERAVTQAHAEAVAAFVAQNRMRPEDIDIVGFHGQTVLHRPEKRLTVQIGDAPALARAIHIPVMHDFRAADVEAGGQGAPFVPVYHRALAQSLEREGPIVVVNIGGVSNITYIDGNDTLIACDTGPGNALLDDFMYRTMNQAFDTEGKFAALGTADEAWIARALELPFFALPPPKSLDRNDFAALKLGDVPPAVGAATLTAFTAAAIARIIPLLPRRPRSWIVCGGGARNLTMLRMLRERVGSATVEAAEALGWASDAIEAQAFGFLAARGLKGLPLSYPATTGVPMPMTGGVIARP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: MTF2_MOUSE
Sequence: MRDSTGAGNSLVHKRSPLRRNQKTSASLNKLSLQDGHKAKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPTSDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAELPLDKESVSENPTLDLPCSIGRTEGIAHSSNTSDVDLTGASSANETTSASISRHCGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
What is the function of this protein?
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21367819, PubMed:21059868, PubMed:23104054, PubMed:22438827).  Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788).  Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819).  Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868).  In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868).  Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254).
What are the official names of this protein?
Metal-response element-binding transcription factor 2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Polycomb-like protein 2, mPCl2, Zinc-regulated factor 1, ZiRF1.
What is the protein family that this protein belongs to?
Belongs to the Polycomblike family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to chromatin as part of the PRC2 complex.
Protein: ABDA_DROME
Sequence: MSKFVFDSMLPKYPQFQPFISSHHLTTTPPNSSSAAVAAALAAAAASASASVSASSSSNNNSSNTIAGSNTSNTNNSSSSPSSSSNNNSNLNLSGGSLSPSHLSQHLGQSPHSPVSSSSPFQQHHPQVQQQHLNHQQQQHLHHQQQQHHHQYSSLSAALQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGNSQAGDSSCSPSPSASGSSSLHRSLNDNSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPRYPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARRDREEQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQQQQQHQQQQQQPQDHHSIIAHNPGHLHHSVVGQNDLKLGLGMGVGVGVGGIGPGIGGGLGGNLGMMSALDKSNHDLLKAVSKVNS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Required for segmental identity of the second through eighth abdominal segments.  Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments.  Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed by Abd-B only in the eight and ninth abdominal segments.
What are the official names of this protein?
Homeobox protein abdominal-A.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LFTR_LEPCP
Sequence: MIPWLPDDSDSAPFPPTRLALGPDSEAPGLLCAGGQLSVARLRMAYRLGIFPWYSQGQPVLWWSTDPRMVLQVAQFRLHRSLKKTLRRFLVTPGNEVRIDSAFADVIDHCSRTPREGQDGTWIVPEVKAAYVALHRAGSAHSFETWVDGELVGGLYGVNIGRMFYGESMFARRTDASKIALAALVAFCLAHEIAWIDCQMETEHLASLGAQPVPRAQFEAHLRRVVDLPAPKDWFYDPSSWARLGDRGPGQPSPSA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.