PharMolix/UniProtQA huggingface dataset:
Protein: HBB_LEPPA
Sequence: VHWEDAEKQYIVSVFSKIDVDHVGANTLERVLIVFPWTKRYFNSFGDLSSPGAIKHNNKVSAHGRKVLAAIIECTRHFGNIKGHLANLSHLHSEKLHVDPHNFRVLGQCLRIELAAALGFKEFTPERNAYFQKFMDVISHSLGREYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FETP_ACIC5
Sequence: MAHNVFCARYKQEMEGLDEPPFDSDFGHKIYNNVSKRAWGEWIEHQKMLLNEYRLQPWTPQAQEFLVEQMNQYFFGEGAQLPKEYVPPSPR
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: Y3120_JANMA
Sequence: MRIILITGISGSGKSVGLTSLEDAGYFCVDNLPPTLLRALVATRQEEHADKLAVAMDARSASSLIGLPADIAWLQSQGHEVKVLFLTAKTDSLIARFSETRRSHPLSHRGFSSTAAEDRRTLTECIREEREMLSGVEEISHVIDTSGMSANKLRGWIKALIESDHSPLTVLFESFAFKFGVPLDADLVFDVRMLPNPHYDSQLRPLTGRDAPVQAFLQDQPDATALLADIRGFVEKWLPAFKKDNRSYLTVAIGCTGGQHRSVYMVEQLAAHFRAHEHVILRHRELD
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein mma_3120.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: YBEY_ERWT9
Sequence: MSGVILDLQLACENEQGLPAETDFQRWLEAVLPQFQPESEVTIRLVDEAESRELNHTYRSKDKPTNVLSFPFEAPPGIELPLLGDLIICRQVVEQEAVEQGKTREAHWAHMVIHGSLHLLGYDHIEDDEAEEMESLETEIMLALGYPDPYISEKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_STRP6
Sequence: MLVSYKWLKELVDIDVTPAALAEKMSTTGIEVEGIEVPAEGLSKLVVGHVLSCEDVPETHLHLCQVDTGDETPRQIVCGAPNVKAGIKVIVAVPGARIADNYKIKKGKIRGMESLGMICSLQELGLSDSIIPKEFSDGIQILPEEAVPGDAIFKYLDLDDHIIELSITPNRADALSMRGVAHEVAAIYGKSVSFPQKNLQESDKATSEAIEVAIASDKVLTYASRVVENVKVKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDYDKFEDHKIVARAARQGESLVTLDGEKRDLTTEDLVITVADKPVALAGVMGGQATEIDGNSQTVVLEAAVFDGKSIRKTSGRLNLRSESSSRFEKGVNYATVLEALDFAAAMLQELAEGQVLSGHVQAGQLPTEPVEVSTSLDYVNVRLGTELTFADIQRIFNQLGFGLTGDETRFTVAVPRRRWDISIPADLVEEIARIYGYDKLPTTLPEAGGTAAELTPTQALRRKVRGLAEGLGLTEIISYALTTPEKAIEFAVAPSHLTELMWPMSVERSALRQNMVSGMLDTVAYNVARKQSNLALYEIGKIFEQEVNPKEDLPNEVNHFAFAICGLVAQKDFQTQAQAVDFYHAKGILDTLFANLNLKVQYVPTKDLANMHPGRTALILLDEQVIGFVGQVHPGTAKAYSIPETYVAELDMAALEAALPSDQTFVEITKFPAMTRDVALLLDREVSHQTIVTAIESAGVKRLTKIKLFDVYEGATIQAGQKSMAYSLTFQNPNDNLTDEEVAKYMEKITKSLTEQVGAEVR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JIP5_VANPO
Sequence: MGKKNKSKINPIEELKSDCLPILELQYSDPLFQIASHPEQAIIISGLATGYVYCHRYNVTVLENYLQQQKKKFVSDADGKKSKKVKFWTVYDIINENKDNADTGSDSGVELIWKTKRHKGSVRCIALDSDGQFVYTVGTDNVLKKADVLTGKVVKKTNLKNDNGGKYTKMVKSPTHSLLILGDENGTVIVLNSETLQETNRLTKVHNGDDAINDIFHFAKRSIYRYISLGQTTLAYWDARESNESDFKLDPEDTTSKRKVMLSDDQEDEVLCGTFVDPEVGDNLVCGMGDGILTVWKPERNDLEDQLNRIKIAKEESIDCIVPTLQDDNCIWCGCSNGNIYKADIKKGKVVEVRNHSSLDEVSFLDLDYDYRVISGGMDKVKIWQSRNEVSEEEDDEESESFSDSDSDSDSDSDSDSDSDRDRDRDSDSDGDSDGDDIGNGSDVNDSGASGSENDSSDVWEGLENGSDDEPVQEKDETSGSDMDDIDEGSDSSEGELIGLSREELIAELDEDIMEESEQEGEKLQKKRKNEPSKKNTKNLKKVKPSYNDSHGIRKFEGL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RSMA_SHEHH
Sequence: MSNKVHLGHTARKRFGQNFLTDENVINRIVGAISPDNDHVMVEIGPGLAALTEPVASGIDKLIVVELDKDLVERLQTHPVLKDKLEIHQGDALKFDFNQLVREDKQMKVFGNLPYNISTPLMFHLFEFAQHIENMHFMLQKEVVLRLSASPGTKAYGRLTVMAQYHCQVMPVLEVPPGCFTPPPKVDSAVVRLVPYKNKPWPCKDVDLLRNLTTTAFNMRRKTLRNNLKQLLSDEDFAELGIDATLRPEQIRVDQYVAMANHVFDKK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_DESAL
Sequence: MNWNAHGAKILDMIRNSKPLVHHITNLVVMNDTANVTLHLGALPVMAHAVEEMEEMTSIASALVINIGTLSKHWIEAMFKAGKTANDKGIPIILDPVGAGATSYRTETCHRLLEELSVSVIRGNLGEVSILAGLGGEVKGVESVSAGGDAVDVAKALAAKQNCTVSITGKEDVISDGTRTVLVDNGHEWLTTLTGTGCSSTTAVAAFSAVERIPVTAAACALMCYGLAAEIAAPQAKGPASFKVAFYDALYNLNAEQIEKGGRVREVS
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: ISCS_SALPB
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFLTLDGTFGNPASRSHRFGWQAEEAVDIARNQIAELVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLNELEAAMRDDTILVSIMHVNNEIGVVQDIATIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRIRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMETEMARLRGLRNRLWNGIKDIEEVYLNGDLEQGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGMNDELAHSSIRFSLGRFTTEEEIDYTIDLVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MZM1_PARBD
Sequence: MATTPLPNALSAYRLLLRATRIAFQGDFTTLHAARAEARKHFDQNRRLGVDTPKHIQHAVETAEILRTNVVQGVRVEGSGEAGKEEQRYELRIHEHIERGDNDTIKTAGNKGIKAAVGKTCSQS
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RESA_BACHK
Sequence: MKKNRLLFRVIILLILCGAVGFTLYQGYFTKEEKMEIGKEAPNFVVTDLEGKKIELKDFKGKGVFLNFWGTWCKPCEKEMPYMNELYPKYKEKGVEIIALDADETDIAVKNFVKQYDLKFPVAIDKGGEIIKTYGVIPLPTSFLIDKDGKVIQEIKGEQTKEQLEEYLKKITP
What is the function of this protein?
Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis.  May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached.
What are the official names of this protein?
Thiol-disulfide oxidoreductase ResA.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. ResA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane.
Protein: RL2_AGRVS
Sequence: MALKNFNPTTPSQRQLVIVDRSGLYKGKPVKSLTEGLSSKGGRNNLGRITVRFQGGGHKRTYRLVDFKRRKFDVEGTVERLEYDPNRTAFIALITYADGEQAYILAPQRLAAGDKVIASDKAVDVKPGNAMPLQYVPVGSIVHNVELKPGKGGQVARSAGAYVQLVGRDAGMAILRLSSGEQRLVHGTCLATVGAVSNSDHGNINDGKAGRSRWRGKRPHVRGVVMNPVDHPHGGGEGRTSGGRHPVSPWGKPTKGKRTRSNKSTDKFIMRSRHQKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: HSLV_CHLPD
Sequence: MKHDEQLLIRSTTVLGVIRDGKAALGSDGQMTLGNTVLKHSTRKTRRLYHGQIIAGFAGATADAVTLLDRFEEKLEAFSGRLERAAVELARDWRTDKYLRRLEAMLAIVTAEKALIISGTGDVIEPEDGIVAIGSGSMYALAAARSLLAHTTLSAREIVHESLKIAADICIYTNDHIVIEEV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3781_ENT38
Sequence: MMIPWQDLAPETLDSLIESFVLREGTDYGEHERSLEQKVADVKRQLQNGEILLVWSELHETVNIMPRNQFRG
What are the official names of this protein?
UPF0270 protein Ent638_3781.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: ERCC3_RAT
Sequence: MGKRDRVDRDKKKSKKRQYEEEEEDEDDAPGNESQEAVPSAAGKQVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTVEGSGGASTSQGVDAQAKSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDSLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSIAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQASRRFGTMSSLSGADDTVYMEYHSSRNKASTKHVHPLFKRFRK
What is the function of this protein?
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPB, TFIIH subunit XPB, DNA excision repair protein ERCC-3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LCDH_BACCZ
Sequence: MERLNNMGKNSIKKVTVVGTGVIGNGWISRFLSQGYDVVATDPAKNAEVRMRQSIENAWPALEKQGLAEGASKDRLTFELDLAKAVADADLIQENVPEREALKRRVLAEIDHFSKSEAIIASSTSGLKPSILQEDCQRPERVIVAHPFNPVYLIPLVEVIGGKDTSPETINISEQFYQSIKMKPLVISTEVEGHIADRLMEAIWREALHLINDGVATTEEVDAAIIYGPGLRWALMGPFLTLHLAGGEQGMRYMLEQFGPALKLPWTKLVAPELTNELANRVVEGCEAQTTGYSIKKLEQRRDEFLIELIQLLEKYWPGANLKGKL
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
What are the official names of this protein?
L-carnitine dehydrogenase, CDH, L-CDH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OXIR_STRAT
Sequence: MDLTGRRAVVTGGASGLGAETVRALAAAGAEVTVATRRPLSAEPLVQELAAAGGAGRVTAEALDLSDPASVESFARAWRGPLDILVANAGIMALPTRTLAPNGWEMQLATNYLGHFALATGLHAALRDAGSARIVVVSSGAHLDAPFDFEDAHFARRPYDPWVAYGQSKAADVLFTVGARRWAADGITVNALNPGYILTRLQRHVDDETMRAFGVMDDQGNVKPLPYYKTPEQGAATSVLLAASPLLKGVTGRYFEDNQEARTVQGQEDQPGGVAAHALDPEAADRLWEYGTDALRAA
What are the official names of this protein?
Probable oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NPIIB_ARTGP
Sequence: MQVIVALAALSSLAAPALGFSIPRGVPVSQSMIDVKLSAAGNSMVKATITNNGDRALNLLKFHTIMDSNPTRKVTIESQDGKEVQFTGMMPRYKHTDLKPTYFISLPPKGTVEHSFDIASTHDLSRGGKFTLKAEGMVPLAEENGTTITGAAKYNSNELHMDIDGNKAASVERAMGIVKRSGPLTRIGKRTSIDMQSCSNRQELQALTAALRASAQLSSMAAQAVQQNQEKYMEYFKDPQYAQTVQSRFQSVAQESSSTSGGGTTYHCTDLMNGCEQGVLAYTLPSQNEVFNCPIYYSDLPPLSNECHAQDQATTTLHELTHNPAVQEPFCEDNGYGYERATALSAEKAVQNADSYALFANGKFLPMSSMLVTQD
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog MGYG_00813, Deuterolysin MGYG_00813.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UREG_ANADF
Sequence: MHDHSLHSGHDHGLGPGSFHDRGAPHARGDLRRRAFTVGVGGPVGSGKTALVLALCRALRDSRSLGVVTNDIFTREDAEFLVRNDALPAERIRAVETGGCPHAAIREDVTANLLALEELTEAHRPEILFCESGGDNLAAHFSRELADYTIYVIDVAGGDKVPRKGGPGITQADLLVVNKTDLATAVGADLDVMARDAARMRGDGPVVFAQVTRGVGVPEIAGHVLHAYRHAVGAPH
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_CUPMC
Sequence: MRAAPPTSLQALIEALKVLPGVGPKSAQRMAYHLLQHDREGARKLGDALRGAVDGIRHCTRCNTFTELEICGTCSDPERDATLLCVVETPADQVMIEQTLTYRGQYFVLMGRLSPLDGIGPKEIHLDRLLARATDPELGGPASEVIVATNFTSEGEATAHYIGEMLKARGLKVSRLARGVPVGGELEYVDAGTIARAVMDRRTL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RS28_THEPD
Sequence: MSSQAPADKFSDAVPAEVVQIIGRTGITGEVTQVRVRVLEGRDKGRILTRNVRGPVRVGDIVMLRETEREARKIATR
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: RPO6_HALMA
Sequence: MNAQESRYEKARKLGARALQLAHGAPVLIETEHTQPILIAAEEYDAGVLPFTVNRSD
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3O1D_MYCTU
Sequence: MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR
What is the function of this protein?
Involved in the degradation of cholesterol (PubMed:18031290, PubMed:21987574).  Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids (PubMed:18031290).  Has a clear preference for 3-ketosteroids with a saturated A-ring, displaying highest activity on 5alpha-AD (5alpha-androstane-3,17-dione) and 5alpha-T (5alpha-testosterone, also known as 17beta-hydroxy-5alpha-androstane-3-one) (PubMed:18031290).  Is also involved in the formation of 3-keto-1,4-diene-steroid from 3-keto-4-ene-steroid (PubMed:21987574).  Catalyzes the conversion of 3-oxo-23,24-bisnorchol-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) to 3-oxo-23,24-bisnorchola-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) (PubMed:21987574).
What are the official names of this protein?
3-oxosteroid 1-dehydrogenase, 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase, KSDD, 3-oxo-Delta(4)-steroid 1-dehydrogenase, KSTD.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily.
Protein: TLR4_RAT
Sequence: MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFTNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT
What is the function of this protein?
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS).  Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate.  In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42.  In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36.  This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.  Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).  Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
What are the official names of this protein?
Toll-like receptor 4, Toll4.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Protein: Y1262_STAAM
Sequence: MSYLVTIIAFIIVFGVLVTVHEYGHMFFAKRAGIMCPEFAIGMGPKIFSFRKNETLYTIRLLPVGGYVRMAGDGLEEPPVEPGMNVKIKLNEENEITHIILDDHHKFQQIEAIEVKKCDFKDDLFIEGITAYDNERHHFKIARKSFFVENGSLVQIAPRDRQFAHKKPWPKFLTLFAGPLFNFILALVLFIGLAYYQGTPTSTVEQVADKYPAQQAGLQKGDKIVQIGKYKISEFDDVDKALDKVKDNKTTVKFERDGKTKSVELTPKKTERKLTKVSSETKYVLGFQPASEHTLFKPIVYGFESFLKGSTLIFTAVVGMLASIFTGGFSFDMLNGPVGIYHNVDSVVKAGIISLIGYTALLSVNLGIMNLIPIPALDGGRILFVIYEAIFRKPVNKKAETTIIAIGAIFMVVIMILVTWNDIRRYFL
What are the official names of this protein?
Putative zinc metalloprotease SAV1262.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TAM_SINFN
Sequence: MSWSAAQYVKFEDERTRPARDLLAQVPDLPAGPAFDLGCGPGNSTQLILERFPNNPLVGIDSDENMLEAARKRLLGLRFERADLIGWTPPQGAALFFANAVFQWLPKHIDLLERLVDALVPGGTLAVQMPDNLDEPSHLLMQETAEERAFAAAFSGRTIRRVPLPSPRTYVERLAPKVARVDVWHTTYYHPLASANAIVEWVKGTGLRPYLDALPANRRKDYLAAYAEKIRRAYPAMGDGRVLLRFPRLFIVAVKAA
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C7161_ARATH
Sequence: MYMAIMIILFLSSILLSLLLLLRKHLSHFSYPNLPPGNTGLPLIGESFSFLSAGRQGHPEKFITDRVRRFSSSSSCVFKTHLFGSPTAVVTGASGNKFLFTNENKLVVSWWPDSVNKIFPSSMQTSSKEEARKLRMLLSQFMKPEALRRYVGVMDEIAQRHFETEWANQDQVIVFPLTKKFTFSIACRSFLSMEDPARVRQLEEQFNTVAVGIFSIPIDLPGTRFNRAIKASRLLRKEVSAIVRQRKEELKAGKALEEHDILSHMLMNIGETKDEDLADKIIGLLIGGHDTASIVCTFVVNYLAEFPHVYQRVLQEQKEILKEKKEKEGLRWEDIEKMRYSWNVACEVMRIVPPLSGTFREAIDHFSFKGFYIPKGWKLYWSATATHMNPDYFPEPERFEPNRFEGSGPKPYTYVPFGGGPRMCPGKEYARLEILIFMHNLVNRFKWEKVFPNENKIVVDPLPIPDKGLPIRIFPQS
What is the function of this protein?
Possesses triterpene oxidizing activity.  Catalyzes the C28 hydroxylation of alpha-amyrin, beta-amyrin, and lupeol, producing uvaol, erythrodiol, and betulin, respectively.  Catalyzes the C28 carboxylation of alpha- and beta-amyrin.
What are the official names of this protein?
Cytochrome P450 716A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.