PharMolix/UniProtQA huggingface dataset:
Protein: NUCKS_MOUSE
Sequence: MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPAKKIRSSPREAKNKRRSGKNSQEDSEDSEEKDVKTKKDDSHSAEDSEDEKDDHKNVRQQRQAASKAASKQREMLLEDVGSEEEPEEDDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKAKVGRPTASKKSKEKTPSPKEEDEEAESPPEKKSGDEGSEDEASSGED
What is the function of this protein?
Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR).  Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
What are the official names of this protein?
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, JC7.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL20_CERS5
Sequence: MSRVKSGKVTHARHRKVIKAAKGYYAARSTNFRTATQAVDKANQYATRDRKARKRNFRALWIQRINAAVRLFDLEMTYSRFINGLAKAGIEVDRKVLADLAVHEPEAFNAIAARAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MNMA_HERAR
Sequence: MAKKRVVIGMSGGVDSSVSAWLLKEQGYEVIGLFMKNWEDDDDSEYCSTRQDWIDAASVADVVGVDIEAVNFAAEYKDRVFAEFLREYEAGRTPNPDVLCNAEIKFKAFLDHAMLLGADMIATGHYARVREVTSGPDAGQVQLLKAVDASKDQSYFLHRLNQAQLSKTLFPLGEIRKTEVRKIAEQLQLPNASKKDSTGICFIGERPFREFLNRYLSYQPGPMKTPDGTIVGEHVGLSFYTLGQRKGIGLGGMKTHKNTDGNSGPWYVARKDVANNTLYIVQGHDHPWLLSSALSAGQMSWVAGRAPSEELVAAKTRYRQADVACSQHATADNLALAFDTPQWAVTPGQSAVLYQGDVCLGGGIITASTLTE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_KLEP3
Sequence: MAVLQVLHIPDERLRKVAEPVKEVNAEIQRIVDDMFDTMYAEEGIGLAATQVDIHQRIIVIDVSENREERLVLINPELLEKDGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLRSRA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: C7124_PRUMU
Sequence: MALLTLFNQIWQEGQLQSSTSSFNIFLVPILCLSIFILFSLTRSSSPSEKNRKLKLPPSPPRLPWIGNLHQLGSFPHRSLRALSKKYGDVMFMHFGKVPTLIVSSAEMAKDVMKTQDIVFCSRPQTTAPSILFYDGHDIAFAPYGEYWRQVRRICVLELLSLKRVHQFQYARVEEVAELVSKIRKASASANGAPINLGELLVSTSNNIICRCILGQKFEDKEDNWFGETTKELMTQVMSFSFGDFFPSLKWIDRARGYLAYLKSIWLEFDKFFDKLIDEHKAAQKEGKPRKKDIVDILLDVQNDGSLDFELTTSNVKAILQDMFVGGSDTSWTAAIWLMSELSQNPRVMKKVQEEVRRVAGKRGYVEESDINEMKYLTCVIKENLRLHPPAPLLLPREAMSDVKLGGFDIPAKTQVFVNAYAVQRDPKVWDKPDEFMPERFEENNVGFVGQDFELIPFGAGRRVCPGLAFGVASAQYVLANMLYWFDWKLPSGGSKLAETLDMSEVYGLTVHKKSPLYLVPTPYSP
What is the function of this protein?
Involved in L-phenylalanine-derived cyanogenic glycoside biosynthesis, including prunasin and amygdalin defensive agents (PubMed:25015725).  Catalyzes the conversion of phenylacetaldoxime (PAOx) and phenylacetonitrile (PAN) into mandelonitrile (MAN) (PubMed:25015725).  To a lower extent, can convert various aromatic aldoximes and nitriles; mediates the transformation of 4-hydroxyphenylacetaldoxime, 4-hydroxyphenylacetonitrile, indole-3-acetal-doxime and indole-3-acetonitrile into the corresponding hydroxynitriles, but cannot use the aliphatic compounds 2-methylpropanaloxime and 2-methylpropanenitrile as substrates (PubMed:25015725).
What are the official names of this protein?
Phenylacetaldehyde oxime monooxygenase CYP71AN24, Cytochrome P450 71AN24, Phenylacetonitrile alpha-monooxygenase CYP71AN24.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MAND_PECCP
Sequence: MKIVSAEVFVTCPGRNFVTLKITTDSGLTGLGDATLNGRELPVASYLNDHVCPQLIGRDAHQIEDIWQYFYKGAYWRRGPVTMSAISAVDMALWDIKAKAANMPLYQLLGGASRTGVMVYCHTTGHSIDEVLDDYAKHRDQGFKAIRVQCGVPGMETTYGMAKGKGLAYEPATKGSLPEEQLWSTEKYLDFTPKLFEAVRDKFGFNEHLLHDMHHRLTPIEAARFGKSVEDYRLFWMEDPTPAENQACFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTITHAGGITGMRRIADFASLYQVRTGSHGPSDLSPICMAAALHFDLWVPNFGVQEYMGYSEQMLEVFPHSWTFDNGYMHPGEKPGLGIEFDEKLAAKYPYDPAYLPVARLEDGTLWNW
What is the function of this protein?
Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-galactonate dehydratase family member PC1_0802, D-mannonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: PUR5_DECAR
Sequence: MTQNTSLSYRDAGVDIDAGDALVERIKPLAKKTLREGVLGGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLRLAFDLNRHDTVGQDLVAMSVNDILVLGAESLFFLDYFACGKLDVDTAAAVVGGIAKGCELAGCALIGGETAEMPGMYPAGEYDLAGFAVGVVEKSKAIDGKASITPGDVVLGLASSGAHSNGYSLVRKIIERSKPDMNAKFDGERTLADVVMAPTRIYVKQVLATMQKVTIKGMAHITGGGLLENVPRVLPENTVAELEKAAWPRPKLFDWMQAEGNVAENEMHRVFNCGIGLVIVVAAADADAAMAELKAQGEAVYRIGKIRARSGDEAQTLVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_ECOLI
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds very close to the 3' end of the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9, Large ribosomal subunit protein bL9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: EFP_BACC1
Sequence: MISVNDFRTGLTIAVDNGLWQVLDFQHVKPGKGAAFVRSKLRNLRTGSVQEKTFRAGEKVEKAHIENRRMQYLYASGESHVFMDNGTYEQIELGEKQIERELKFLKENMEVSIMTYQGEVLGVELPNTVELQVTETEPGIKGDTASNVTKPATLETGLVVQVPIFINEGETLIINTGEGKYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL5_HORSE
Sequence: MKVFAAALAVILATATFCTPASASPYASDTTPCCFAYISRPLPRAHIQEYFYTSSKCSIPAVVFVTRKKRQVCANPEKKWVREYINTLEMS
What is the function of this protein?
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils.  Causes the release of histamine from basophils and activates eosinophils.  May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5.  May also be an agonist of the G protein-coupled receptor GPR75.  Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases.  By activating GPR75 may also play a role in insulin secretion by islet cells.
What are the official names of this protein?
C-C motif chemokine 5, Small-inducible cytokine A5, T-cell-specific protein RANTES.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PNG1_ASPOR
Sequence: MADSIHHSQRAQGSNNFDVSELTNAFEQLMRNKRFHRLQEHSRARTHSPSPSPSQVSSPGPYAPPHPSRAPPPPPTAAPFQPPQYPQQPQQYPSNQSSMLQGLPIVPSPPQDQASLKFRNLLHVLSVTPTKYENPGLLDEALSLIPLDRLYSEAEEESQILQAQAASVGGRPEWGYQDCVIRSLLRWFKGSFFQFVNNPPCSRCFRPTIAQGNTPPLPDETARGATRVELYRCSEMSCGAYERFPRYSDVWQLLQSRRGRVGEWANCFSMFCRALGGRVRWVWNSEDYVWTEIYSEHQRRWVHVDACEGAWDQPRLYAEGWGRKMSYCIAFSIDGATDVTRRYVRSSAKHGAARNRAPEEVVHWVILEIRRKRRENLSKTDQKRLMKEDEREEKELRHYTASALAAELNNLLPQNQTTGRLDEQKTPVSRQEAAAEWLAASQRNSGHSGPDHSQGGR
What are the official names of this protein?
Protein png1.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase-like superfamily. PNGase family.
Protein: QUEF_CHLCH
Sequence: MKLEILESFENKYPNRDYTIEIVNPEFTSVCPITGLPDFGTITIRYVPNQRCVELKSLKYYFFEFRNAGIFYENITNKVLDDMVALLEPRSISVITEWKARGGITETVSVHYTSQS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_LEGPL
Sequence: MKRYFVTGTDTDCGKTFVTNQLVNYFSSSAAIKPIASGCEYSENQLVNSDALLHQQQNHLPLEVVNPWRFRLPVSPHLSARADGASIDVHKVADYCLNLQLNDIKKLFIEGAGGLMVPLNEQDTWLDFLKLTRIPVILVVGMKLGCINHTLLTQEVFEINKIKCQGWIANCLDQDMLMLDENISTLEAKLKYPLLARTNYGGKISDICLSSL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_GLOC7
Sequence: MYSRIPVNLPQNSYEIAIASGSLSRLGAEMSTLNLGKKVLLVSNPEIYDYYGEIAVNSLKTAGFEVATHLIPEGEIYKTLDSITQIYDTAVENFLERSSTMIALGGGVVGDMTGFAAATWLRGISFVQVPTSLLAMIDAAIGGKTGVNHPKGKNLIGAFHQPRLVLIDPQVLKTLPPREFRAGMAEVIKYGVIWDANLFSQLEAAKKLDEFSDLDEDLLQTIITRSCQAKADVVSKDEKEAGLRAILNYGHTIGHGIESLTGYSQIIHGEGVAIGMVAAGTIAVKLQLWSEQEANRQDALIKKAGLPTEVPPNVNIEAIIEALQTDKKVKAGKVRFILPQQIGTVTITDQVTSDVIREVLAQIQSKA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFF1_TALMQ
Sequence: MARSRTAGRCNPFAFYRVPVTVFVTLIYVALLAPIIVVHHILPAVPESDVEGLDLHEAWRDLQHLTNGFHPYNSHKNDEVRSWLLTRIDEIVSTNVKDAKQQDGVRTFVFDDNQSNLTVVQSNLGVYFEGTNIIVYICGQEDDKREWWKEPGLSPSGKGGVLVNAHYDSVSTGYGATDDGVGVISCLQLIKYFTTPGHEPTRGLVVLLNNGEEDFLNGARVYSQHPISKLPHTFLNLEGAGAGGRATLFRSSDTEVTKFYQRSPYPFGSVFSDAGFKLGMIRSQTDYIVFEGDMGLRGLDVAFMEPRARYHTNQDDAKHTSQQSLWHMLSAAVATTEGLVSDTSHDFEGRPQGPGKVPSGTGSGAVWFDLFGTAFAVFEIHTLFALSVTLLIVGPLTLFITSIILANQDRMYLFGISVPVDDGFGSVPLRGWRGFFRFPFIFGSTTASVVALAYLMAKINPMIAHSSEYAVWSMMISAWVFVAWFLSRIANFARPSALHRIYVLTWMFLLTWVLLVITTVYENRDGIASGYFVIFYAFGTFMATWISYLELFSLPKKSDFANKVSGQISSRPTSLGGSRLLTPSGESVGQHPEDEEPTESTSLLRGQRTSFANYTRPVEDDGDGDLLSTGVSTDVSEARDFNVYGYEQPWSANLPKWTWILQFLLIAPIVIILIGQLGLLITSAIHQTMQDGSSTLVPYLIIALLTTFLFMPTLPFIHRYTYHIPTFLFLIFVATLVYNLVAFPFSGNNRTKLFFLQEVDLDTGANRVSLTGIQPFVSDAVASIPSADGQNISCIPKMDRTECSWESSLVPHVITHPGSEKEETPLNEWVKYKATRLEPGSQNSNRAQIKISGLNTRGCLLHFDKPITRFHVTGSAIDSRFPSNPSLEDGTEDGVREIRLWSRTWGNQWVVDAEWASDEDVNNEEDTLTGKATCLWSDANTQGAIPALDEVIQYSPDWVAITKLDAGLVKGSRSFEV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: END4_BACHK
Sequence: MLKIGSHVSMSGKKMLLAASEEAVSYGATTFMIYTGAPQNTRRKPIEELNIEAGRKHMEQNGIEEIIVHAPYIINVGNTTKPETFQLGVDFLRMEIERTSALGVAKQIVLHPGAHVGAGADAGIQQIIKGLNEVLTPDQTVNIALETMAGKGTECGRSFEEIAKIIDGVKYNEKLSVCFDTCHTHDAGYDIVNDFDGVLNEFDKIVGIDRLQVLHINDSKNVRGAGKDRHENIGFGHIGYKALHHIVHHPQLTHVPKILETPYVGEDKKDKKPPYKLEIEMLKNGTFDEGLLEKIKAQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: EVPL_MOUSE
Sequence: MFKGLSKGSQGKGSPKGSPAKGSPKGSPNKHNRAATQELALLISRMQANADQVERDILETQKKLQQDRQNGEQNQALQHQQETGRNLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECSEYRALYEKMVLPPDVGPRVDWARVLEQKQNLVREGHYGPGMAELEQQVAEHNILQREIEAYGQQLRTLVGPDANTIRNQYRELLKAASWRRQSLGSLYTHLQGCTKQLSALADQQGRILQQDWSDLMPDPAGVRREYEHFKQHELLAQERSINQLEDDADRMVELGHPAIGPIQVHQEALKMEWQNFLNLCICQESQLQRVEDYRRFQEEADSVSQTLAKLSSNLDTKYGFGTGDSSGSPTELLLQLEAEEKQLAIAERAVGDLQQRSQEVAPLPQRRNPSKQPLHVDSICDWDSGEVQLLRGERYTLKDNADPYTWLVQGPGGETKSAPAACLCIPAPDPEAVAKASRLATELQTLKQKLSTEKNRLKAAAVEHLQPGQQAPAGSAPADPQGQTLLSQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQRLQSLGAEKEAAQQECEAFLSTKPTGSAALQLPVVLNSVKNRYNDVQSLCHLYGEKAKAALGLEKQIQEADRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLSSWLEQLPHHRVQPSDGPSQISYKLQAQKRLIQEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVEYKEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIRVEKDPVLEGERARVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLSTKICILEPETGNDMSPYEAYKRGVIDRGQYLQLQELECDWEEVTTSSPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHRYKDGRLPISEFALLVAGETKPSSSLSIGSIISKSPVCSPGPQSTGFFSPGLSFGLTEDSFPIAGIYDTTTDNKCSIKAAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAVERGLIENTSTQRLLNAQKAFTGIEDPVTRKRLSVGEAIQKGWMPQESVLPHLLVQHLTGGLIDPKRTGRIPVPQAVLCGMISEDLGQLLQDESGYEKDLTDPITKERLSYKEAMGRCRKDPLSGLLLLPAMLEGYRCYRAASPTLPRSCVR
What is the function of this protein?
Component of the cornified envelope of keratinocytes.  May link the cornified envelope to desmosomes and intermediate filaments.
What are the official names of this protein?
Envoplakin, 210 kDa cornified envelope precursor protein, p210.
What is the protein family that this protein belongs to?
Belongs to the plakin or cytolinker family.
What are the subcellular locations of this protein?
Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.
Protein: PPM_THEKO
Sequence: MRLFGTAGIRGTLWEKVTPELAMKVGMAVGTYKSGKALVGRDGRTSSVMLKNAMISGLLSTGMEVLDADLIPTPALAWGTRKLADAGVMITASHNPPTDNGVKVFNGDGTEFYVEQERGLEEIIFSGNFRKARWDEIKPVRNVEVIPDYINAVLDFVGHETNLKVLYDGANGAGSLVAPYLLREMGAKVLSVNAHVDGHFPGRKPEPRYENIAYLGKLVRELGVDLAIAQDGDADRIAVFDEKGNYVDEDTVIALFAKLYVEEHGGGTVVVSIDTGSRIDAVVERAGGRVVRIPLGQPHDGIKRYKAIFAAEPWKLVHPKFGPWIDPFVTMGLLIKLIDENGPLSELVKEIPTYYLKKANVLCPDEYKAEVVRRAAEEVERKLSSEIKEVLTISGFRIALNDGSWILIRPSGTEPKIRVVAEAPTEKRRDELFEMAYSTVSRIVKEAEKK
What is the function of this protein?
Catalyzes the conversion of deoxyribose 1-phosphate to deoxyribose 5-phosphate.  Shows also weak activity with glucose 1-phosphate and mannose 1-phosphate.  Could be involved in pentose biosynthesis.
What are the official names of this protein?
Phosphopentomutase, PPM.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MSRA_SCHPO
Sequence: MQIAIIAAGCFWGVQEVYLRKFIPAAAILKTSVGYTGGITADPTYKEVCTNTTNHAEALKIEFDEKLTSYDKIIEFFFAMHDPTTSNQQGNDIGTQYRSAIFTTNPEQATIAKRVMNEVQAKHYPNKKIVTQILPAGKWWDAEDYHQLYLEKNPDGYRCSSHFLRWNVFE
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Probable peptide methionine sulfoxide reductase, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MDM12_AJECG
Sequence: MSIDIDWERATSGPDGELLAERIRSFIHDKFQQIVLPRFIRSVQVTSFNFGTIPPELEIRDLSDPFPDFYEDDDENFSDSSEEGSPTREPVDRYGNRVDSWQANSPGGPGGQMYESNQPLRMPAWEEHTGISPLRGPMNFGDINPYLFPRSGTPGIPGGTSNLGYYMPLSGLSSSQTPLGAVARGNPFSGGWPDAHGARPSRRRSEAEPDSAQSRPSTANTGNTLPSRDSMSISDPHHSHASQGMPNNQGQALEPNIPPTSPNHPLDDTPPRRMREQKAEDFQVFCRTKYAGNISLSLTAEILLDYPMPSFVGLPLKLNITGLTFDAVAVIAYIRRRIHFCFLSPEDADTLMGPETAGGGGGGDTSEPNSSRRKPSSLLREIRVESEIGRKENGKQALKNVGKLEKFVLEQVRRIFEEEFVYPSFWTFLI
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: CF119_RAT
Sequence: MITPRSSQSLEMKVQTELEHSPKLQEEPDRSPSLVDSSVIRIGTDEQNESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEEMREVLAELLELGGPEQSLRDAIILDLFSHALIFCRQQGFSLEQTSAACALLQDLHKACVATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLSYMGLQSLHLWPEEKEDEEATVEQAATPQEEEPEAVTEAEQQPSEVCILQTYIKCQLNKELRQLQQLVEERLKESEERLSNRLAALERPYQTPPSKGKSKAK
What are the official names of this protein?
Cilia- and flagella-associated protein 119, Coiled-coil domain-containing protein 189, Spergen-4.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm. Note=In elongated spermatids, enriched in the principal piece of flagella where it is peri-axonemal (PubMed:15489334). Disappears from sperm heads upon acrosome reaction (PubMed:15489334).
Protein: CSRA_BACSU
Sequence: MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHRKEIYLTIQEENNRAAALSSDVISALSSQKK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Represses expression of flagellin (hag) in a post-transcriptional fashion.  Specifically binds to 2 sites in the 5'-UTR of hag mRNA in a cooperative fashion; the second site overlaps the Shine-Dalgarno sequence and prevents 30S ribosomal subunit binding (PubMed:17555441).  Mutation of either binding site abolishes CsrA regulation of hag expression (PubMed:17555441, PubMed:21895793).  Repression is greater in the 1A96 than 168 genetic background and higher in minimal than rich medium (PubMed:17555441).  Translation repression is antagonized by FliW (PubMed:21895793).  Partner switching by flagellin between FliW and CsrA provides a flagellar assembly checkpoint to tightly control the timing of flagellin synthesis.  Flagellin binds to assembly factor FliW, freeing CsrA to repress translation of the flagellin mRNA.  When the flagellar hook is assembled flagellin is secreted, depleting intracellular flagellin, which frees FliW to interact with CsrA and inhibits CsrA binding to mRNA.  This derepresses flagellin translation and provides protein for flagellar assembly.  Once the flagellar filament is completed cytoplasmic flagellin levels rise and CsrA translation repression of flagellin reinitiates (PubMed:21895793, PubMed:27516547).  Overexpression leads to a dramatic reduction in motility, a significant reduction in flagellin synthesis and reduced flagella assembly (PubMed:21895793).
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_CALEP
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQNYIASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL15_LACGA
Sequence: MKLNELKPNEGSRRNRKRVGRGTSSGYGKTAGRGQKGQLARTGGKTRLGFEGGQMPLFRRMPKRGFKNVNRKEYAIINLNDLNRFDDGSEVTIDTLKSSGLVKKELAGVKLLANGELKVKLTVKVNKVSEAAKKAVEAAGGTVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.