PharMolix/UniProtQA huggingface dataset:
Protein: EYA1_MOUSE
Sequence: MEMQDLTSPHSRLSGSSESPSGPKLDSSHINSTSMTPNGTEVKTEPMSSSEIASTAADGSLDSFSGSALGSSSFSPRPAHPFSPPQIYPSKSYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGALWAGIKTESGLSQSQSPGQTGFLSYGTSFGTPQPGQAPYSYQMQGSSFTTSSGLYSGNNSLTNSSGFNSSQQDYPSYPGFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGVTSQAVTDPTAEYSTIHSPSTPIKETDSERLRRGSDGKSRGRGRRNNNPSPPPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRVSSHSDLMALHHALELEYL
What is the function of this protein?
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620).  Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.  'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442).  Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (PubMed:14628042).  Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro).  Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (PubMed:10471511).  Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (PubMed:17098221).
What are the official names of this protein?
Eyes absent homolog 1.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. EYA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: HEM3_SCHPO
Sequence: MPSCTSFPIGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTRELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPPGSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVALALLKNGAGPILEEHQRSSDSEESLKNY
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: YCD3_SCHPO
Sequence: MKPRPYSVFLFLHIVFYSLLSAVNGSPSLDYFETCSNFVPRAGIPTFSPYAVIKNFDEVNRMYYIQVVGNLSGVITIVGGNGSHIHAASVYSETYALGKLVTSNTTKLCDVVMDPHSFEVPIKCPWAAGSAAFMVKVPFKSTLSDYSKYELTTLTTRVIVVDGTPEKNVITCMKFGLSTTLYYFYPVISYLVVVSLAYVSFSIIYALFLNPWTGSLDPFKSIFNFNMDPDALRLTSLGFFDFVQYLQFAVSTAQVSVMFPKFYINIMAALSWGTALFRFPIFSEPAEYQFADFADLSVASSSYADYLPKSYGMYSFLDSIGIGTACWLPFLIVMVIYLFAALFVALLVIFLKWLMSRIFNETIAETRWDTWSFIAGSLIRLYFLTYFPTVAYMSFQFVAPPTGYEIIPVLWFIFFGIFIPVYLYMNLAFVEPSSKLLEDQTYLHLFGSIYNSFREERVMFWIFPIAVQFMRGITVGVIGSSGSAQLAIFFILEVANVVAYAYVRPHFPQTSMNTLNTFISTMRLITVILMIPLDPRLKVLGISRDLLAYAILFIHIMVCILFLLLSTQRFMEVSARLLGAKSESKGVPLDRPFGWARVFGINELRRRRLKDPYSNGNTMMFDHSTYNSNEMSVPLTPVSVCSNSLKKDGEAAPPKLFVQTNCIPPVTQASSLVPSKNNTASSSSLMLDSPVTPSSPYSTSQGYSFYRPPKPKSSVRKRDMDQLRALQLDFLNNKPNLLRHDVNYAVREADVYHPHVDTSIDSLSQISSQPFEMRPTAIPPPPKNAFQRAWQIVQSTAKSIWHSDPPKESEKGFVVLRSRPRPNLQKPLPQLHIEPSRDEQYSMERKKTDDSLAESAWSIPHP
What are the official names of this protein?
Uncharacterized membrane protein C1322.03.
What is the protein family that this protein belongs to?
Belongs to the transient receptor potential (TRP) ion channel family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: IF1C_CHAVU
Sequence: MSKQNLIEIEGLVTESLPNAMFRVCLDNGCEVLTHISGKIRKNYIRILPGDRVKVELSPYDLTKGRITYRLRSKNTNT
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: METE_BURL3
Sequence: MVTTHNLGFPRIGAKRELKFGLERYWKGESSRGALKALGAELRQRHWNDQRDLDLAPVGDFAFYDQVLDMSFTLGNLPKRVQGFHGDALDNYFRVARGRSAQSAEEHAACCGGVSAGEMTKWFDTNYHYIVPEFHADTNFSLDPSRLLQQLAEAQAQGVAAKPVIVGPVTYLWLGKAKDDSDRLALLPKLLPVYGALLDTLTAQGVEWVQIDEPILVTELDAAWQQAFRTAYAALETRRIKVLLATYFGQLQGNLALATSLPVDGLHVDAINARDEVDALARELPAERVLSVGAINGRNIWKTDLNATLDWLEPLAKRLGDRLWLAPSCSLLHVPVDLASEEKLDAEIRSWLAFALQKLDELKVLATALNEGRDKVADALAANAAAIHSRRHSPRVNNPAVKAAIARIDAQLGNRVSPYTQRAPKQSARLNLPAFPTTTIGSFPQTGEIRQARSQFKAGTLDEAGYRKAMQAEIERSVREQESLELDVLVHGEAERNDMVEYFGEQLDGYAFSQFGWVQSYGSRCVKPPILFGDISRPKAMTVEWITYAQSLTNKPMKGMLTGPVTILNWSFVRDDQPRSVSCYQLALAIREEVLDLEKAGVRVIQIDEAALREGLPLRRAQWGEYLKWAVESFRITANGVQDDTQIHTHMCYSEFNDIIASIADMDADVITIETSRSDMELLDAFDNFKYPNEIGPGVYDIHSPNIPTQEHIVGLMKKAAERIPAERLWVNPDCGLKTRQWAEVIPALTNMVAAAKTLRNQVQ
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: CDK12_AILME
Sequence: MPNPERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAAPLGTIIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGTDRSDRLHKHRHHQHRRSRDLLKTKQTEKEKNQEVSSKSGSMKDRISGSSKRSNEENEDYGKAQISKSSSNKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSPKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFMSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPIFLPRKENSLVEAKDSGLESKKLTRGVKLEKSAPDTELVNIPHLNTEVKNSLDTGKVKLDENSEKHPIKDLKAQGSRDSKPIALKEEIVTPKETETSEKETPPPVPAVTSPPPPLPTTSPPPQTPPLPPLPPLPAIPQQPPLPPPQPAFSHVLASSTSTLPPSTHPRTSTLSSQANSQPLAQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETPPSKPVKKEKEQRPRHLLTDLPLPPELPGGDPSPPDSPEPKAVTPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMDPPDLPHWQDCHELWSKKRRRQRQSGVVIEEPPPSKASRKETTSGTSAEPVKNSSPAPPQPASGKVEPGTGDAIGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSEHMAPEESLKEAPPALVVQPSAEQTTSEASSTPADMQNMLAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLIEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPHPNRTYGNTDGPETGFSATDTDERNSGPALTESLTQTLVKNRTFSGSVSHLGESSSYQGTGSVQFPGDQDLRFARVPLPLHSVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLNWGGSAQSSAYGKLYRGPTRVPPRGGRGRGVPY
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation.  Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.  Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'.  Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.  Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 12, Cell division protein kinase 12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Protein: CYOE_ALCBS
Sequence: MSERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASAAINQIMDQKIDAIMKRTEKRPLVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTLFGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAVTGEAHPYAWLLVLIIFVWTPPHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYLLSALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASWLGA
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: O16C_CONBU
Sequence: TAEDSRGTQLHRALRKATKLPVSTRCITPGTRCKVPSQCCRGPCKNGRCTPSPSEW
What are the official names of this protein?
Conotoxin Bu12.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SPRTL_STRU0
Sequence: MNLTDYVNEVSLEDFAKPFKHHAYWNKRLRTTGGRFFPKDGHLDFNPKMFQEFGQETFRRIVRHELCHYHLYFEGKGYQHKDLDFKRLLKEVDGLRYAPRSTKERGSINYRCQKCGHCYKRQRRINLQKYVCSFCRGHLKEINQSKD
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUGN_RAT
Sequence: MGTSSARPAVLALAGLALLLLLCLGPGDVSGNKLKKMLQKREGPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNQNGHDYYGDYYQRHYDEDAAIGPRSREGFRHGASVNYDDY
What is the function of this protein?
Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145, PubMed:21349154).  ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145).
What are the official names of this protein?
Augurin, Esophageal cancer-related gene 4 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the augurin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Apical cell membrane.
Protein: ARAB_ECO27
Sequence: MAIAIGLDFGSDSVRALAVDCATGEEIATSVEWYPRWQNGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQRAAVVGIGVDTTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHTPGNVDYSRYIGGIYSSEWFWAKILHVTRQDNAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFTETWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQHPELKEQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTAQGIAVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPRSEQAQRFEPLYRRYQQWAMSAEQHYLPTSAPAQADQAVPTL
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: Y552_HAEIN
Sequence: MLSLTAESCELFNIPFYQFAQMKKFCPEDIPAIKADYKLHWDNWKAIIQSVSAQLGTPFAKPHIESWTNGWQVRAHFFAYFKYEFNQNSAAIFSVLLNRRRLRVCLDWHCYRADRSQINVQQYNQWLDQFDFKQFADFEIWREDESEYDDFRQVKVISEKNLILRSDEDFWCIGKSIEKAELNQIDPVLFITHTIQQLQPLYDRCHQ
What are the official names of this protein?
Uncharacterized protein HI_0552.
Protein: KMT5A_XENTR
Sequence: MGRGKKMSKPGDGRSGDVPDTGRTGGTNENHPKINGEVAHLGQPKIYSFMSPTKSPSARPPLQEENSVAHHESKCPGKPLTETRKKAEVEKKRISSGTELSVKPSEQRETECNSIGEFLDPKQEQTDVRRNIALPPADKLNHQKMVKDKPLRRKAQRKKSPNRKLTDYYPVRRSCRKSKTELESEEKKRIDELIQTGKEEGMKMDMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREATYAQDSNTGCYMYYFQYLNKTYCIDATRETGRLGRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDRRKSSLEAHPWLKN
What is the function of this protein?
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins.  Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).  H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.  Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.  Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis.  Involved in chromosome condensation and proper cytokinesis.  Nucleosomes are preferred as substrate compared to free histones.  Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.  Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
What are the official names of this protein?
N-lysine methyltransferase KMT5A, Histone-lysine N-methyltransferase KMT5A, Lysine-specific methylase 5A, SET domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms (By similarity).
Protein: MSHD_MYCBO
Sequence: MTALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQQRTEHLLVAGSRPGGPIIGYLNLSPPRGAGGAMAELVVHPQSRRRGIGTAMARAALAKTAGRNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIRTYAGTSDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILAFGDSPRERPGRLLGFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSLARRLGGRKTLDPAVEPAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYALAGTDN
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: ACHB3_MOUSE
Sequence: MTGFLRVFLALSATLSGSWVTLTATAGLSSVAEHEDALLRHLFQGYQKCVRPVLNSSDIIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRREGFYSYPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLEKLPRWLCMKDPRDRFSFPDGTESKGTVRGKFPGKKKQTPTSDGERVLVAFLEKASESIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLTASVLGSVLIFIPALKMWIHRFH
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit beta-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RLME_VIBPA
Sequence: MSKQKHSASSGRWLKEHFDDKYANEARKKGYRSRAYFKIDEIQTKDKLLKPGMTVVDLGAAPGGWSQYAAKIVGDSGQIIACDLLPMDPIAGVSFLQGDFRDDAVLEALLDRIQPLMVDVVMSDMAPNIAGNNSVDQPRAMYLVELALDMCRQVLAPNGSFVVKVFQGEGFDQYVKEVRDMFKVVKIRKPDSSRARSREVFVVATGYKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCTA_ECOK1
Sequence: MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: TDCD_EDWTE
Sequence: MHEYPVVLVINSGSSSIKFSVLDAQRCEVLLAGIAEGINSGSATLSVNGAAPVALAQRGYEPALAAICAELEKRSLIDSVALIGHRVAHGGNLFQQSAIVDDEVMEKIRRISPLAPLHNYANLSGMVSARHLFPGVTQVAVFDTSFHQTLAPEAWLYALPYRYAQEYGVRRYGFHGTSHRYVSQRAHHLLGLSEADSGLVIAHLGNGASICAVRNGRSVDTSMGMTPLEGLMMGTRSGDVDFGALAWIASQTGQSIADLEQMVNTESGLLGISGLSSDLRVLERAQREGHQRADLAIRTFVHRIARHIGGHAASLRRLDGIIFTGGIGENSALIRRMVLEHLSVFGITLAPDKNNMPGSAGERIISGEDSAVICAVIPTDEERMIALDALRLGKIMPSIEYA
What is the function of this protein?
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP.
What are the official names of this protein?
Propionate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family. TdcD subfamily.
Protein: CP6A1_MUSDO
Sequence: MDFGSFLLYALGVLASLALYFVRWNFGYWKRRGIPHEEPHLVMGNVKGLRSKYHIGEIIADYYRKFKGSDPLPGIFLGHKPAAVVLDKELRKRVLIKDFSNFANRGLYYNEKDDPLTGHLVMVEGEKWRSLRTKLSPTFTAGKMKYMYNTVLEVGQRLLEVMYEKLEVSSELDMRDILARFNTDVIGSVAFGIECNSLRNPHDRFLAMGRKSIEVPRHNALIMAFIDSFPELSRKLGMRVLPEDVHQFFMSSIKETVDYREKNNIRRNDFLDLVLDLKNNPESISKLGGLTFNELAAQVFVFFLGGFETSSSTMGFALYELAQNQQLQDRLREEVNEVFDQFKEDNISYDALMNIPYLDQVLNETLRKYPVGVGSALTRQTLNDYVVPHNPKYVLPKGTLVFIPVLGIHYDPELYPNPEEFDPERFSPEMVKQRDSVDWLGFGDGPRNCIGMRFGKMQSRLGLALVIRHFRFTVCSRTDIPMQINPESLAWTPKNNLYLNVQAIRKKIK
What is the function of this protein?
Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Cytochrome P450 6A1, CYPVIA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RUVA_HAEIN
Sequence: MIGRLQGILLEKQPPEILLNVQGVGYELLLPMTSFYDLPEIGQETTLFTHLVVREDAHLLFGFAQKTDRTLFRELIKTNGVGPKLALAILSAMSVEQFAYAIEREELSKLTKIPGVGKKTAERLLVELKGKFKGVKQSDFFVESTHIPLSPSIESHSESSSDEAISALIALGYKPVEAEKMVKRVAKPELTSEQVIREALKVAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PUR8_STAAW
Sequence: MIERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTKEELDECFDPKHHLNQVDTIFERAGLA
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: C14D1_ORYSJ
Sequence: MESFFVFFTAAALPVVVAAAVIAGLCITAAWLARPRRVAEVFRRQGIDGPPPSSFLAGNLPEMKARVAAAASAAAPTADGEETASAGGGGGGRDFEKDGFDDYCTRIFPYFHKWRKAYGETYLYWLRRRPALYVTDPELIGEIGRCVSLDMGKPKYLQKGQEPLFGGGVLKANGACWARQRKVIAPEFYMARVRAMVQLMVDAAQPLIASWESRIDAAGGAAAAEVVVDGDLRSFSFDVISRACFGSDYSRGREIFLRLRELSGLMSETSVIFSIPSLRHLPTGKNRRIWRLTGEIRSLIMELVRERRCAARAAREHGGKAAPPSPPERDFLGSIIENSGGQPRPDDFVVDNCKNIYFAGHETSAVTATWCLMLLAAHPEWQDRARAEVLEVCGGDGAAAPAAPDFDMVSRMRTVGMVVQETLRLFPPSSFVVRETFRDMQLGRLLAPKGTYLFVPVSTMHHDVAAWGPTARLFDPSRFRDGVAAACKHPQASFMPFGLGARTCLGQNLALVEVKTLVAVVLARFEFTLSPEYRHSPAFRLIIEPEFGLRLRIRRAGGQDATSQVDTSTAPVHSSHN
What is the function of this protein?
Catalyzes the 16alpha,17-epoxidation on non-13-hydroxylated gibberellins (GAs), including GA4, GA9, and GA12.  No activity with GA1, GA20, GA53 or ent-kaurenoic acid.  Reduces the biological activity of GAs.
What are the official names of this protein?
Cytochrome P450 714D1, Protein ELONGATED UPPERMOST INTERNODE 1, EUI1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: ISPE_RHIE6
Sequence: MPEAGLAEAFGVTEEARAKINLALHVTGQRPDGYHLLEMLVTFADCGDRLGFLPAQADAFTLSGPFGAMLAGDGNNLVLRARDLLREQVGALAFPVHIHLQKNLPIASGIGGGSADAAATLRGLMRLWGMDLPAETLASLALTLGADVPMCFESRPLIARGIGEKIEAVPDLPAFAMVLANPLKGVSTPEVFRRLAAKNNPALHLARSLSATSDWLTAIGSARNDLEPPACELVPEIAMISQMLQAQGALITRMSGSGATCFGIFSTMTAAQEAAAALHGERPDWYVQATETVSGGM
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.