PharMolix/UniProtQA huggingface dataset:
Protein: MURA_PROM5
Sequence: MVCESNNKSYLKSQNLKIIGKNSLRGNVKISGAKNSALVLLAASLLTDEKIILDNVPLLTDIEKMGNILKNLGVKLHNKDHQLIIDSKNISIQELPYELVNGLRASFFCIGALLTRFGKASLPLPGGCNIGERPINEHINGLRALGAEIIIEKEVVKAKLIKKKSKLFGANIRLNCPSVGATETLIMAASLAEGRTIIENAAREPEIQDLCQMLNKMGAKIYGAGKEKIIIDGVQKLHGCSHKVIPDRIEAGTFLIAAAATSSSITISPVIPNHLEAVLNKLEESGSKIEKKGNSISISGKSIKAVKIKTAPFPGFPTDLQAPFMALMTIAKGTSMISERIFENRMHHVNLLNQMGAAITVDDNTAIINGVKKLKGMNLVGSDLRSSAALIIAALISENISHIYGLEHLDRGYENFEFKLTKLGAKIIREVDGGIQTKSKNSSEIHPTKNLDINFNVA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_MESFL
Sequence: MAKEIILTQEGIEELKHELKHLLEVVRPQVIEELVEARNQGDLSENADYDAARNRQAEVEARIKELETMISKAKLIEDSSTTDGAIKIGSKVKFIMLNTKQTREVKIVGAVEADPFKGLISNESPIAKAILGKKVGESVEVKDINAPYSIEIKEVN
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: ACCA_LISMO
Sequence: MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRTFGDDAAIVGGIATFKGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASLAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLTAQAEEINKTITKSLHALMAFSEEQLIKQRYEKFKKIGVYETI
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_JANMA
Sequence: MASGKEIRGKIKSVENTKKITKAMEMVAASKMRKAQDRMHAARPYSDKIRNIAANLSQANPEYTHPFLVKSDASKTVGFIIVTTDKGLCGGMNTNSLRIVTTKLRELEAEGKKVEAVAIGNKGLGFLNRIGARVVSHAVQIGDTPHLDKLIGPVKVMLDAYQDGKLDAVYVVYTKFINTMKQEPMMEQLLPLAVDKLKADEDSLAWDYIYEPDAQTVIDELLVRYVEALIFQAVAENLASEQSARMVAMKSASDNAGSVISELKLVYNKTRQAAITKELSEIVAGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CCME_YERPN
Sequence: MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRLRIGGMVMPGSVQRDAKTLEMSFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNTVHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTTGNAL
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: TM214_BOVIN
Sequence: MAAKTAGGGRWEVVKKGRRPGAGGSGKGGGGDRRALGEANGVWKYDLTPPIQTTSTLYERGFEKIMKRQNKEQVPPPAVEPKKPGNKKQAKKVATLTNQNQKQGRFRSLEEALKALDLADLQKELDKSQSVFSGNPSVWLKDLASYLNYKLQVPPSEPTLSQHPHDYPYSLVSRELRGIIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIVTTNLGKFLELLRSHQSRPAKCLTIMWALGQAGFTNLTEGLRVWLGIMLPVLGIKSLSPFAIAYLDRLLLMHPNLTKGFGMIGPKDLFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPESTLHTYFPSFLSRATPGCPLEMKKELLRSLTECLMVDPLSTSVWRQLYPKHLSQSSLLLEHLLRSWERIPKKTQKSLQETIQSFKLTNQDLLRKGGGSNQDVVTCDSACKSLLQQARGFQLPWTRLLLLVLVFAIGFLCHDFRSHSSFQASLSGQLLQSSGVLPAGQQACTKIYSYSLQGYSWLEKTLPAWGSHLLTVVRPGLQLAWAHTNATVGFLSAHCASHLAWFGDSLANLFQRLQTQLPDTLNQLLRSLRELLLFLYHSILLPTWHMLLEALAQIQEHCHEACRGEVTWDCMKTQLSEAAHWTWLRLQDTTVAFLDWALAMISQQ
What is the function of this protein?
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis.  Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity).
What are the official names of this protein?
Transmembrane protein 214.
What is the protein family that this protein belongs to?
Belongs to the TMEM214 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS17_XANC8
Sequence: MSDNNEKQTLRTVEGRVVSNKMDKTVTVLVERQVKHPLYGKYIKRSSKLHAHDADNACNEGDVVRVTEIAPMSKTKNWRVVEIVTRAAV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PSME4_ARATH
Sequence: MHLYNEWLPPPVAEETKKEKESFARVVRCVKELHRPDDPESVYATLKWISVIELFVRAKSELSVEDVSELVEIGLQIFHSSENKLYAQVRWGNVLVRLINKFRKKLSLKVQWRPLYDTLIHAHFSRSPGPEGWRLRQRHFMAVTSLIRSCRRFFPQGAASEIWSEFMSLLENPWHNSSFEGSGFVRLFLPTNPENQDFFSEKWIKNVLELWDSIPNCQFWNSQWTSVLARVIKNCSFIDWESYLPMLFSRFLNMFEVPVANGSGSYPFSVDVPRNTRFLFSNRTTTPSKSIAQSIVYFLKPGSSAHEQLEKLVNLLEQYYHPSNGGRWTYSLERFLLHLVIAFQKRLQREQQDPDSLPATCLGKPERVAFVGVVLKLIDRGQYSKNEHLSETVAAATSMLSYVEPSLVLPFVASRFHLALETTTATHQLKTAMMSVAFAGRSILQSSMSTAKSQDLGGDVDDRMFLDLIGISLSNALLGMDANDPPKTLATMQLIGSIFSNMAVLDDSSDDLSFMTMASFSEWLDEFLCRLIALLQHLEPNSVINEGLSSSATSGTFLVEDGPYYYCMLEILLGRLSGSLYNQALKKISKFVQTNILPGAIAEVGLLCCACVHSTPEEAVAQIVEPMLLAVISSLKEIPVNGYGGKGSAETLVSNKQDKQTLSPALEAAIDYQLKVLSVAITYGGSSLLPYKGLLIEAISSAFNSSSWKVNGAGDHLLRSLLGSLILYYPIDQYKCLSRHPAAPALEEWISTKASSKDEQVAHSRWHVPTQEETQFANELLDLHLQSALDDLLSICQSNIHSDAGDEKTHLKVTLLRIDSTLQGVLSCLPDFRPSPRHDMVEDLQFFIAGASGSCVGSAEIREKTAITIHAACKYLLEKKSDDSILLILIIRIMDALGNYGSLEYDEWSNHRQAWKLESAAIVEPPANFITEFNSKGKRRPRWALIDKAYMHNTWRSSQSSYHLFRTDGNFSPPEPLTFLVDDLLTLCLHNYETVRVLAGKSLIKLLKRWPQLLSKCVLSLTENLRKPDVQEYVVLGSCAILSSHSVLKHLTTDPKSFSSFLLGILSSSHHESMKSQKAIIELFVKYNIHFAGLSRNILRSLESHVEGSTSGDLVSQIGSMSFDSSSLHWRYNLMANRVLLLLVMSSRIDPSFSLKILDETAGHFLKNLKSQLPQTRILAISALNILLKESPHKMQGKDQPSVSSQETENANSSLDLALSQIFREEGFFKETFESLSHIHITDTDSSSRGNHGSSSFQSMADKSITRFYFEFSASWPRTPSWISLLGSDIFYPSFARIFKRLAQECGVPVLLALKSPLEEFCNAKERPKQCVAAEALAGVLHSDVNGLFNEWDSWIMVQLQNVILGQSVESIPEWAACIRYAVTGKGKQGTKIPVMRQQILDCIVAPLPPTATTTVVAKRYAFLSAALIELSPPKMPVTEVKLHIVLLDELICNMSHSSAQIREAIGVILSVLCSNIRLRMSYQQEYPTEEGKTDVDSQLKEENWFKLISAKASEAVKNIQQASISDSLDTSTDVDMGNAQSNGDSLDDVKWMETLFHFIISSFKSGRASYLLDVIAGFLYPVMSLQETSHKDLSILAKAAFELLKWRVFPESHLQKVIGVILSSADDSNWRIRSSTLTYLRTFMYRHTFILTHEDKQKIWKTVEKLLVDSQVEVREHAAAVLAGLMKGGDEDFAADFRDRSYAEANSIQKRRNRRKSSSTQSIAGVHGAVLGLVASVLSVPYDMPSWLPEHVTLLARFAGEPTPIKSTVTKAVAEFRRTHADTWNIQKDSFTEDQLEILADTSSSSSYFA
What is the function of this protein?
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response.  Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry.  Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism.  involved in DNA damage response: binds to acetylated histones and promotes degradation of histones (By similarity).
What are the official names of this protein?
Proteasome activator subunit 4, Proteasome activator PA200.
What is the protein family that this protein belongs to?
Belongs to the BLM10 family.
Protein: DPOL_NPVLD
Sequence: MSSVNLMEWSALKTQLQAGRDAGKARVSIGPADTARITRMTYADNHLIVFMNARLAKENHRLYQFYAEVRCDLYSYKSCYGTHASATCHRNCTSYKTFVMPGLRDVHTDKLHVVKFKRSDEKRDKNCLDGYLADVNRVHMQTSLLEGQYVRFKNAHACRDYRLSHTAKDVHEFESMLERVQVSALSHEILPVVACYDIETHSDGQRFSAPDADFIISIAVVVRRDAADTRICLFYSPDDPVDLSSSSSSPPAAPDTAAVHFRAERDMIAAFFQLLPLLNADVVLDFNGDKFDLPFLTGRANKLCGPAEAARATKIARYDLSPVNVVTQQSYDKFSNKLHSHYLTYYIHIDLYQFLSTDSEHNDLENFQLNTVAEHYLKKSKVDLPIHDMLQMYGEKRLSRIVEYNVQDCVLPVELFLKLEIADYMYTQCMLLYLCTDDLLRNISHKITVAYFHLALTNTVAAADPTPDPYFFNKYDLSVTSGRKRAFNEPAPSANAIDLSQLKRTPVDAARIPPSAVKLCSTRQSCTYKGGKVLSPKPGFNRWVATLDFNALYPTIMMWEGVCMSNVFIASDGNVYLDKNVNAVNPKLLKTLSEMRVRYKGLRDQCEYNSFYYKLYDKIQNALKRIANSIYGYYGIFFKPLANYITKMGRGKLKEVVGKVEAMSDDPRILREFGLSKINFSVIYGDTDSCFIRVLFDEAELAPDRRQTAIRSIVQDHVCKTLNDSWCGYKMSLENIMLSLILLKKKKYCYLNNEQRTKYKGWLIKRDMPLFMRKAFRATVDSLLRGHSTACALGLLAEQMLRYYREFGAPRENLVDYCFSMSYNETSTTAKRRKEEDPARKPVITIAKHCRELLANPGVDFLPGNGDRIQYVLVDVKEKITQKAFPLKLFDPDSPTLQISWLKHMNILCTFMNELIQVFGNRPEFEHYFGAIVDEYTSAQMYDVRYPVLVPTRRAKAGKSAKKNDSDSDSDSDDDDDPATTPVNYHSLFSMHLKKPKRQAVGEFEPCPQCVARA
What is the function of this protein?
Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: PE2R4_RABIT
Sequence: MSTPVANASASSMPELLNNPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRLQFPDTWCFIDWRTNVTAHAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVTSAACRGHPTASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPDLVREISQNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSGQHCSDSRRTSSAMSTHSRSFLSRELKEISSTSQTLLYLPELSENSLAGRNLLPGVPLVGLAQADTTSLRTWRGSETSDSSQGQDSESVLLVDEVGGGGRAGPTPKGSSLQVTFPSETLNLSEKCI
What is the function of this protein?
Receptor for prostaglandin E2 (PGE2).  The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase.  Has a relaxing effect on smooth muscle.  May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
What are the official names of this protein?
Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGB_PROM5
Sequence: MKETIQTDWIKSEAFNLENCCNDNPLNILGPHFFKGKWVTRVWMPEADEVNITFKDKTYKTTTPNHKWMFEAILHEDPKNNYQINVLRGGVSHSQQDPWAFKDEWMGEVDRHLFAEGNHHHIWKKMGAHISEDINQKGVMFCIWAPNAKSISIIGDINSWDGRHHPMQKRLGGVWELFMPILKEGDVYKYEIRTQQGHIYEKADPYGFLHEVRPQNGSIISKLNNFNWEDSSWITSRDSSSQINKPISVYEMHLGSWMHDSTDNKYIEKNGNPRHPVPAADLKPGTRFLTYPELTEKLIPYVKERGFTHIELMPISEHPFDGSWGYQVTGWYAPTSRYGTPNEFKEFINKCHAEGIGVILDWVPGHFPKDKHGLAFFDGCHLYEHGDPRIGEHKEWGTLIFNYSRNEVRNFLVANLIYWFEEFHIDGIRVDAVASMLYRDYLRPEGEWIPNENGGNENLEAVKFLQQANHVLFQHFPGALSIAEESTTWPMVTEPTNVGGLGFNLKWNMGWMHDMLDYFEIDPWFRQFHQNSVTFSITYNYTENFMLALSHDEVVHGKSHLLHKMPGDDWKKFANTRALLTYMWTHPGKKTIFMGMEFGQRQEWNVWDDLQWELLEYEPHKGIRNLIDDLNKLYKNEPSLWKNDFDPYGFQWIDCDDTSNSVISFMRRENESNEWLVVIANFTPNFHESYKIGVPLEGYYKEIFNSDGSKYGGSNKGNMGGKDTLKYNIHNYENALEIALPPLSVSIFKHQLKK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: COAA_PAEAT
Sequence: MSVTLQRTEANGDGASPFVELDRQTWSRLAAQMEQPLNEEDIFRLRGLGDPLDMKEVREVYLPLSRLLHLYVEASHQLHAATTTFLGEQTQRTPFVIGVAGSVAVGKSTIARVLREMLRRWPGTPNVELITTDGFLYPLAELKRRHLLERKGFPESYDRRGLLRFVSEVKGGAEEVRAPWYSHVTYDIVPGKEVVVRRPDVLIVEGLNVLAPARPRMDGKQGLAVSDFFDFSIYVDAKTSYIEEWYVDRFRKLRTTAFAQPESYFHRYATLSDDDAESTARGIWKRINEPNLEENVLPTRGRAQLVLTKDADHSIRRMLLRKV
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5051R_ASFWA
Sequence: MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYRLENDLPLAHLLIKKACEDHNYEVIKWIYENLHIYNIMDTFGCAIAHKDLRLYRLGYTFIYNRIVPYKYHYLDVLILSGLHLLYKVAAKGYLDFILETLKYDHNNDNLDIILTQAATYNHRKILTYYIPQLTYAQIEQCLFMAIKKKSSKKTLNLLLSHLKLSIKLIKKISQYVATYNSTNIIGILNMRRKKKIYLDIILTKFVKKAIFNKFVVRCMDTFSINPERIIKMAARINKMLLVKKISEHAWKNHAARLKHLKHAVYTMKHKDGKNRLMNLIYDHYYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCLLDTIRFKNLLLDCSHIIGKNAHDATNITIVNKYIGNLFAMGVLSKKEILQDYPSIYSKHYMP
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 505-1R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
Protein: Y3821_HALH5
Sequence: MANEFRICDECQATNIKTLIPKLKKLDPNATIDIRCQSYCGPGRKKSFTFVNNRPVAAPDEDQLIEKIKKKLKK
What are the official names of this protein?
UPF0741 protein BH3821.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: SMUF2_MOUSE
Sequence: MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling.  In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1.  Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation.  SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation.  Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation.
What are the official names of this protein?
E3 ubiquitin-protein ligase SMURF2, HECT-type E3 ubiquitin transferase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane. Membrane raft. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Protein: GMT2_NEOFI
Sequence: MASARNGVSKDELLPVYERRSQRDGDISGSVKSFASTIGNSASAAVLAYCLSSISMTLVNKYVVSGASWNLSFLYLAMQSFIGTVAILACKKTGLIQNLALFDLKKAQTWLPISLLLVGMIYTGNKALQFLSVPVYTIFKNLTIIVIAYGEVLMVGGGVKPLALLSFGLMVLSSVVAAWADIQNATTATVGASSDSTAAALSALNAGYAWMGTNVIFSASYALGMRRVIKKTNFDNWDVMFYNNLLSIPILLLASVLAEDWSSENLQRNFPAELRQSLFIGILYSGVAAVFISYCTAWCVRATSSTTYAMVGALNKLPLAVAGIVFFAAPVTFGSVSAIVLGFISGLVYARAKSTGA
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter 2, GMT 2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FBW12_HUMAN
Sequence: MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSILVMYSLNT
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box/WD repeat-containing protein 12, F-box and WD-40 domain-containing protein 12, F-box only protein 35.
Protein: Y4OL_SINFN
Sequence: MSENGKDVYEALRADVICGTACARRMGAIVFHGLWRGLAVLIAPHQSAIARQQSAPRFKTTSMVAHDRQLVHMLANMVLAAETGSHVY
What are the official names of this protein?
Uncharacterized protein y4oL.
Protein: RECA_PECCA
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMNVETISTGSLSLDVALGAGGLPRGRIVEIYGPESYGKTTLTLQVIAAAQREGKICAFIDAEHALDPIYAQKLGVDIDNLLCSQPDTGEQALEICDALSRSGAVDVIVVDSVAALTPKAEIEGEIGDSHVGLAARMMSQAMRKLAGNLKNSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGSVKNGDEVVGSETRVKVVKNKIAAPFKQAEFQIMYGEGINTFGELIDLGVKHKLVEKAGAWYSYNGEKIGQGKANATTYLKEHPEMYNELNTKLREMLLNHAGEFTSARDFC
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_HELPH
Sequence: MGGFTSIWHWVIVLLVIVLLFGAKKIPELAKGLGSGIKNFKKAVKDDEEEAKNEPKTLDAQATQTKVHETSEIKSKQES
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL33_SHEB5
Sequence: MAKAKGNREKIKLVSTAKTGHFYTTEKNKRNMPEKMEIKKFDPVIRQHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ACKA_SYNJB
Sequence: MNILVVNAGSSSLKSSLFLTVEGRVEATPIWQAQVDFTYKPGEALIQTRRRGGGWEPFPSASPEGGIGQLAPLFQSLWQGEGSLLPQAAEIGGVGHRVVHGGSLYRQPTLITPEVERAIEQLIPLAPAHNPAALAGIRLLRQLLPGIPQVAVFDTAFHQQMPLAAALYPLPYAWAEQGIRRYGFHGINHEHCARRAAEILNRPLEELRLITCHLGNGCSLAAIRGGRSVDTTMGYTPLEGLMMGSRSGSVDPGILIHQLRQGMSVDELDRILNRESGLKGVSGLSSDMRVVLEAMEAGHARAELAFELFVHRLRSQIGAMLMSLDRLDALVFSGGIGENSAPVRAAACADLGFLGIQIDPVLNAGSPRNCDISTSDAPVRVLVISAQEDWAIATACQNLLQGE
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAL1_GORGO
Sequence: MDKPRKENEEEPQSAPKTDEERPPVEHSPEKQSPEEQSSEEQSSEEEFFPEELLPELLPEMLLSEERPPQEGLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFKGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI
What is the function of this protein?
May be involved in transcriptional regulation.  Modulates various viral and cellular promoters in a promoter context-dependent manner.  Does not bind DNA directly (By similarity).
What are the official names of this protein?
Transcription elongation factor A protein-like 1, TCEA-like protein 1, Transcription elongation factor S-II protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD_RENSM
Sequence: MTRMLIVGPPGSGKGTQAEWISDRLGIVAISTGDIFRANVKGETPLGLEAKKYMDAGDYVPDSVTNKMVRDRLQQEDVQHGFLLDGYPRTSAQVNELDDILSAGGEKLDVVLQLTADDEELVRRLLGRAKESGRSDDDEKVIRHRLNLYHTQTEAVVVRYQKLGLLAKVDGIGAIDEVTDRIMAAIDGVRAAK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URM1_COPC7
Sequence: MAEPTPTTTLNIKIEFGGGLELLFSNQRSHKVSIPSLVPKDNTTSAKNPPPKDDLLKPADITYLIHHMRDHLLQEREELFVENGTVRPGILVLVNDTDWELEGEGDYVLKDGDEVVFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.