PharMolix/UniProtQA huggingface dataset:
Protein: DBP7_YARLI
Sequence: MMLNLVVADGPRQLSAREKAAKLKKSGLSFAQRKALREEEKKNAWKKEQGGITTTIEDRMKRREQDNPPVRPKPYDKPYEKKPYEKKPFEKKPYEKKSYDKPVASKPVEETDEEKYQRLMEGGKRPEKERWVPQRNFRNRRDMEKAGKDQSQDATPKHHDRDVIGTREDGSLIRRIREKTGAKGGIKGTYVSSIFSEKKEDRIAGEDVQMEDEEEEEAENNAESSNAALKDSTTFSGLGCSQRLVDALVGMQLAKPTKIQRATIPRLIQRERDLFVQAQTGSGKTLAFVLPVLERIMSCDDVSRETGLFAVILTPTRELTTQIYSVLETLCRKACPWIVPGIVIGGEKKKSEKARIRKGVNILVATPGRLADHFDNTEALDLSQVRWVVLDEGDRLMELGFEETITKILRTIEWKSVLRGENYLKDIPKNLKPLPSRRVTVLCSATMKGGVTELGKSTLKDADWVSNDSVEDALAETSVETFSAPSQLVQEWVVVPAKLRLVTLLGALRGDILQSSEKTNTKVIVFLSCSDSVDFHFDVLSRDGSQINKMDTAKTAPLLLDDVSTSVYKLHGSLSQQARTATLASFAKNSTPSILLCTDVASRGLDLPKITHVIEYDPPFSIEDHLHRVGRTARAGQDGRALLFLLPGAEEGYVEKLKQSQQMKKTTYENILAAGFGGKGWDFAATNYHLDVERWVLGDETALDRARRGFTSHIRAYATHIAAEKDMFNVRMLHLGHLAKSFALREAPGKLGKKKDPEKIKVNKDGSLDETQARKKMLDRSRKHVYNSGESAMGGYVLE
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FABH_NATTJ
Sequence: MSNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAAEIALNKSGIEPADLDMIIVATVTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGLRIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGDGAGAAVLGPVENGEEDKGLISFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKALKKIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAIEENLIKEDDLVALVGFGGGLTWGSCLIKW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXC3A_DANRE
Sequence: MNNNSFHEYNFNSEYLNKICCNKSYVCYMGQHFSPCALQENSSTWKRHAEESSSENDKGNVWNFQNLSNVQHPYSFSDDGNHSLDPANALERKKACELSTSCLSTMKYPWMRETHAPTHFSSINAMESGDSKYSNGEAVVRNSSSKRARVAFTSSQLLELEKEFHFSAYLCRNRRLEMAELLKLTDRQIKIWFQNRRMKYKKDHKEKSTAKSSYTYLGTENQPLIISRSTTDSPVPLKFQNNYETPSMNW
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C3a, Homeobox protein Zf-114, Hox-114.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP_THIDA
Sequence: MRTTQFFLSTTKEAPSEAELVSHKLMLRAGLIKRLGSGLYTWMPLGLRVLRRVEAVVREEMNRAGAIELLMPAVQPAELWQETGRWAQFGPQMLKIKDRHEREFCFGPTHEEVITDLARREIKSYRQLPLNFYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHASRESLAATYQAMYDAYGRIFTRLGLRFRAVAADTGAIGGSASHEFHVLADSGEDLIAYCPDSDYAANVELAEALAPAAARGAPQEAMREVETPKQTTCEDVAALLGIPLARTVKLIAVMAGERMVVVLLRGDHMLNEVKLAKIEGLADFRLANEAEIRAVFDCPPGFLGPVGIDRSTIRVIADRAVAVMSDFVCGANKPKFHLAGVNFGRDLQEPDLVADIRNVVAGDPSPDGKGTLALCRGIEVGHVFQLGNKYSQAMNATYLDEAGKAQAMEMGCYGIGVSRIVAAAVEQNHDGKGIVWPASMAPFSVVIVAIGYGKSASVKNAADTLYADLMAVGVEVLLDDRDERPGVMFADAELVGIPHRVTLGERGLNEGVVEYQPRRAAPEQGADARKIAVAEAKAFLMGVLGD
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_ACISJ
Sequence: MNQPLQHTTVLLDEAVHALLGDGDAPAGTFVDGTFGRGGHSRLILQRLGPQGRLVAFDKDTEAIQAAARITDARFSIRHQGFSHLGELPAASVSGVLLDLGVSSPQIDDPQRGFSFRFDGPLDMRMDTTRGQSVAEWLADAETAQIAEVIRDYGEERFAGPIAKAIVARRTERGPIASTAELADIVAGAVKTREPGQNPATRTFQALRIFINAELEELQQALEGSLHVLRPGGRLVVISFHSLEDRIVKQFIAQHSKEVYDRRAPFAPPQPMRLRALERIKPSTDEVAANARARSAVMRVAERTEVPA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBID_RALSO
Sequence: MQPSARRPFDLATPAPNGLRRGRTTGTCATAAVKAALLRLVRGETVDAVEVSLPDPDYCLEVPIARIEPLASGAVRADVLKYAGDDPDNTDGATIFAEVSVNHAGEVRFMAAPGVGTVTQPGLRVPPGEPAINPVPRQMMRMAVDEVLAGGANPGFDLAIGCVDGERIARRTFNPMLGIVGGISILGTSGIVEPMSLAAWMASIEVYVRVALGDAPEAIAFTPGKIGRAYAAHPLALSKKQVVQIANFIGASLDYAQTALEEDRHRLGTLWVLGHPGKLAKVLDGVWDTHSSKSGMAMGSVAAVAAELGVAAALVEQIKTANTVENVIQILQHQPGAQAFWTEIEQRIAARMQPRVPRADRVAVRLFAMDGTPLGAAGQEAGA
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: CHS1_SORBI
Sequence: MAGATVTVEEVRKAQRATGPATVLAIGTATPANCVHQADYPDYYFRITKSEHMTELKEKFKRMCDKSQIRKRYMHLTEEYLAENPNMCAYMAPSLDARQDIVVVEVPKLGKAAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKMLGLRPSVNRLMMYQQGCFAGGTVLRVAKDLAENNRGARVLVVCSEITAVTFRGPSESHLDSMVGQALFGDGAAAVIVGADPDERVERPLFQLVSASQRILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIERALEEAFKPLGITDYNSIFWVAHPGGPAILDQVEAKVGLEKERMRATRHVLSEYGNMSSACVLFILDEMRKRSAEDGQTTTGEGFDWGVLFGFGPGLTVETVVLHSVPITTGAAITA
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 1, Naringenin-chalcone synthase 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: TGT_NEIG2
Sequence: MLKFTLHKKDGLARRGTLELNHGKIETPVFMPVGTYGSVKAMNPQNLHDIKAQIILGNTYHLWLRPGLEVVEQFGGLHGFIGWDKPILTDSGGFQVFSLSDMRKLTEEGCTFKSPINGDKLFLSPEISMKIQTVLNSDIAMQLDECTPGETTREQARKSLQMSLRWAERSKKAFEDLKNPNALFGIVQGAMYEDLREESLRGLEEFDFPGLAVGGLSVGEPKPEMYRMLHAVGPILPEHKPHYLMGVGTPEDLVYGVAHGIDMFDCVMPTRNARNGWLFTRFGDLKIKNAKHKLDKRPIDESCTCYACQNFSRAYLHHLHRAGEILGAQLNTIHNLHFYQVIMAEMREAVEQGKFADWQAQFHENRARGVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: AAEA_YERPY
Sequence: MSTFSLKIIRVGITVLVVVLAVIAIFNVWAFYTESPWTRDAKFTADVVAIAPDVSGLLTEVPVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAAEKQRESSRRHRLGIQALSQEEIDQASNVLQTVQHQLAKAIAVRDLARLDLERTTVRAPAEGWVTNLNVHAGEFINRGATAVALVKKDTFYILAYLEETKLEGVKPGYRAEITPLGSNRILHGTVDSISAGVTNSSSSADSKGLATIDNNLEWVRLAQRVPVKIHLDSEDQQYLYPAGTTATVVITGPNDRDPHQVSPMTKLMHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PURT_VIBCH
Sequence: MFGTATRDNATRVLLLGSGELGKEVAIECQRLGLEVIACDRYADAPAMQVAHRSHVFDMLDADALQQVIDLEKPHFVVPEIEAIATSKLVELEAQGLNVVPTANATRLTMNREGIRRLAAEELGLPTSAYQFADSYESFAAAVETIGLPCVCKPVMSSSGKGQSVIRTPEQIEAAWQYAQQGGRSGAGRVIVEGFVDFDYEITLLTVRAVDGVHFCAPIGHRQEDGDYRESWQPQVMSENAIKAAEYVAEQVVNALGGYGLFGVELFVKGDKVIFNEVSPRPHDTGMVTLISQELSEFALHVRAFTGLPIGQIVQYGPSASAAILGQGQSQNIQFNGLDDALSIPHTQVRLFGKPDIAGRRRLGVALSRGKTTQEATDRAIECAKAVKIHY
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: RECR_PROMP
Sequence: MITFTKPLSKLIGHFEKFPGIGPRTAQRLALFILKQPESSIRDFSKALLEAHSNVGHCKKCFNLTSEEECEICRNTERNQKIICVVAETKDLLALERSREFKGTYHVIGGLISPMDSISPELLEIRSLVERVSKSDIDEIILALTPSVEGDTTSLYIGKLLTPFTKVTRIAYGLPMGSELEYVDEVTLARALEGRTNLI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: DOCK4_HUMAN
Sequence: MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL
What is the function of this protein?
Has a higher guanine nucleotide exchange factor activity compared to other isoforms.
What are the official names of this protein?
Dedicator of cytokinesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
What are the subcellular locations of this protein?
Cell membrane. Cell projection. Cytoplasm, cytosol. Note=Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells.
Protein: ZAPD_SHESM
Sequence: MTDLVYEQPLNEKIRSYLRLEYLNKQLGNNLNHDHQHRCFYPLFSLCELSERCDYRNEVLKDIERNLLQLGKWQELDHVDSEQIEFYIQSLTQAREQLQRPERCGSQLKQDRFLSALRQRFGMPGACCNFDLPQLHFWLAKPWEERQQDYQAWISHFDPLLTPITLLLQLTRSTAHFDNATAHAGFYQGDSAQALSLVRVRVDAAHGCYPTISGHRNRYAIHFVQFDQQRHSDRSIEFLLATCA
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: HEM6_CHESB
Sequence: MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVFEKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQEDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVMVYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHH1_ASPTN
Sequence: MADALASQLNNTSLGDANSDAKWKDQLKTPAKDARPQTEDVTATKGLEFEDFYIKRELMMGIFEAGFEKPSPIQEETIPVALTGRDILARAKNGTGKTAAFVIPTLERINPKSTKTQALILVPTRELALQTSHVCKTLGKHLGINVMVTTGGTGLMDDIIRLNDAVHILVGTPGRVLDLASKGVADLSECPTFVMDEADKLLSPEFTPVIEQLLSFHPKDRQVMLFSATFPLIVKSFKDKHMRNPYEINLMDELTLRGITQYYAFVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHARMLQQHRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHLGLAINLINWDDRFNLYKIEQELGTEIQPIPQNIDKKLYVYDSPDTIPRPISNPSQPPQATGMPSGQHIGDRRHNNHPNGGHYQYNRGRGSYRGGRGQGPRRNVQHDQNRYNASQGQHQSGKSQAAPVS
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dhh1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: SYE_CLOBM
Sequence: MTNKVRTRFAPSPTGYMHVGNLRTALYAYLIAKHDNGDFILRIEDTDQERLVEGALDVIYNTLKITGLSHDEGPDIGGPVGPYVQSERRNIYIEYAEKLIEKGEAYYCFCSKERLDMLRANSEALKRPFRYDKHCIDLSKEEIDKKIAEGVPYVIRQKNPTTGSTSFHDEIYGDISVDNSELDDMILIKSDGLPTYNFANVVDDHLMGITHVVRGSEYLSSSPKYNRLYEAFGWDVPIYVHCPPIMKDEHHKLSKRNGDASFEDLMAKGYLKEAILNYIALLGWNPGGEKEVFSMKELIEAFNYRNINKAPAVFDTKKLKWMNGEYIRALSLDKFHEMALPHYKEALTRDLDTKKISELLHTRVEVLNEIPEQLDFFNNLLEYSPEMYIHKKMKTTYENSLKSLEEVLPRLEALENWTFENIKEVCMNLVKELEVKNGVVLWPIRTAVSGKQFTPGGAFEIADILGKEETLERIKIGINKLKALQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYUA_SAGLB
Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVRKDHLGKSEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
What is the function of this protein?
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity).  Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity).  Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity).  Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity).  This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity).  Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
What are the official names of this protein?
Alpha-synuclein.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane. Nucleus. Synapse. Secreted. Cell projection, axon. Note=Membrane-bound in dopaminergic neurons (By similarity). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity).
Protein: Y1077_STRP3
Sequence: MTTKKAYMYVLECVDKTLYTGYTTDLKKRLATHNAGKGAKYTRYRLPVSLLYYEVFDSKEAAMSAEALFKKRKTRSQKLAYIATHQKEKKNH
What are the official names of this protein?
UPF0213 protein SpyM3_1077.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: SECA_PSET1
Sequence: MISNLFTKIFGSRNDRTIKNLRKTVALINALETQLEALSDDDLKAKTAEFRERYDNGQSLDDLLPEAFAVVREASKRVNGMRHFDVQLLGGMVLHQGRIAEMRTGEGKTLTATLPAYLNGLTGKGVHVITVNDYLAKRDAETNRPLFEFLGLTVGCNVPGMMPQQKKQAYVADITYGTNNEFGFDYLRDNMAFSIDERVQRPLFYAVVDEVDSILIDEARTPLIISGPAEDSSELYTEINTMVPLLELQEKEDEEGIEGDGDFTIDEKSKQVHLTERGQIKVEELLTERGLIAEGDSLYSAASITLLSHVYAALRAHKLYQKDVDYVVKENEVIIIDEHTGRSMEGRRWSEGLHQAVEAKEGVNIQNENQTLASITFQNYFRLYETLAGMTGTADTEAFEFQSIYGLDTVVMPTNKPMVRDDRADLVYLTQEEKYEAILVDIKDCQERGQPVLVGTISIESSEYLSQFLRKEKIKHNVLNAKFHAQEADIVSDAGLPGTVTIATNMAGRGTDIVLGGNWHSEVEKLENPTDEQIAEIKAAWKIRHDAVIDAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMDDALMRIFAGERMTNMMRKLGMQRGEAIEHPWVNRAIENAQRKVEARNFDVRKQLLEYDDVANDQRRVVYSQRNELLEEGDISETITVIRGDVLSNIIDQYIAPQSLAEMWDVPGLEERLKQDFLIELPITQWLADDNKLYEEKLRERIEESVGQAYKQKEEMVGDSVLRQFEKAIMLQSLDQHWKDHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFAEMLENLKIDVVSILSKVQVRAEEDVEKVEEQHRKSENAPREYQHEEVEHVGGEAPQSATVMARSEPKVGRNDPCPCGSGQKFKQCCGKLK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ACL6B_RAT
Sequence: MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth.  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.  ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.  Essential for neuronal maturation and dendrite development (By similarity).
What are the official names of this protein?
Actin-like protein 6B, BRG1-associated factor 53B, BAF53B.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Nucleus.