PharMolix/UniProtQA huggingface dataset:
Protein: JNK1_CAEEL
Sequence: MEERLSTTSSYPSHPGRSVEEDHNTLLASSSISSIIRGTRGHLNNFIESVGNWLVPSSSGRDDDAVSLDSCQSVYSPVRHHINSGTGGGILMEPSSIHVPENYYSVTIGEAQMVVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNHKNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIRHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEAFMMTPYVVTRYYRAPEVILGMGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQPTVRNYVENRPRYQATPFEVLFSDNMFPMTADSSRLTGAQARDLLSRMLVIDPERRISVDDALRHPYVNVWFDEIEVYAPPPLPYDHNMDVEQNVDSWREHIFRELTDYARTHDIYS
What is the function of this protein?
Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity.  By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses (PubMed:17894411).  Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16.  Independently of jkk-1, may regulate some mechanosensory responses, such as response to touch (PubMed:11566876).  Independently of jkk-1 and downstream of mek-1, plays a role in resistance to heavy metals, such as Cu(2+) or Cd(2+) (PubMed:11566876).  Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and arsenite (PubMed:18597494, PubMed:19497412).  Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).  Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals (PubMed:29523076).  Downstream of jkk-1 but independently of mek-1, positively regulates lifespan (PubMed:15767565).
What are the official names of this protein?
Stress-activated protein kinase jnk-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Perikaryon. Cell projection, axon.
Protein: UBIA_XANC8
Sequence: MSKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTLFVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMAFGWGIPMGFAAVQGSVPLLAWLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLVGLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLALR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DCE2_ARATH
Sequence: MVLTKTATNDESVCTMFGSRYVRTTLPKYEIGENSIPKDAAYQIIKDELMLDGNPRLNLASFVTTWMEPECDKLIMDSINKNYVDMDEYPVTTELQNRCVNIIARLFNAPLEESETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPYDKPNIVTGANVQVCWEKFARYFEVELKEVNLSEGYYVMDPDKAAEMVDENTICVAAILGSTLNGEFEDVKRLNDLLVKKNEETGWNTPIHVDAASGGFIAPFIYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVVWRAAEDLPEELIFHINYLGADQPTFTLNFSKGSSQIIAQYYQLIRLGFEGYKNVMENCIENMVVLKEGIEKTERFNIVSKDQGVPVVAFSLKDHSFHNEFEISEMLRRFGWIVPAYTMPADAQHITVLRVVIREDFSRTLAERLVADISKVLHELDTLPSKISKKMGIEGIAENVKEKKMEKEILMEVIVGWRKFVKERKKMNGVC
What is the function of this protein?
Catalyzes the conversion of glutamate to 4-aminobutanoate (GABA).  The calmodulin-binding is calcium-dependent and it is proposed to directly or indirectly form a calcium regulated control of GABA biosynthesis.
What are the official names of this protein?
Glutamate decarboxylase 2, GAD 2.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: CBPYA_ASPTN
Sequence: MRVLPATLLVGAATAAVPPFQQQFQQVLGIPQEEVEQAAPVAPSAPTTPKPLQIFQDQLKSLSDEARKLWDEVSNFFPDSMDHNPVFSLPKKHTRRPDSHWDHIVRGSDVQGVWVTGADGEKQREVDGKLEAYDLRVKKTDPSALGIDPGVKQYTGYLDDNENDKHLFYWFFESRNDPENDPVVLWLNGGPGCSSLTGLFMELGPSSINEKIKPVYNEYSWNSNASVIFLDQPVNVGYSYSGSAVSDTVAAGKDVYALLTLFFKQFPEYAKQDFHIAGESYAGHYIPVFASEILSHKKRNINLQSVLIGNGLTDGYTQYEYYRPMGCGEGGYPAVLDKGTCQSMDNALPRCQSMIKSCYESESSWVCIPASIYCNNALIGPYQRTGQNVYDVRGKCEDESNLCYKGMGYVSEYLNKAEVRQAVGAEVDGYDSCNFDINRNFLFHGDWMKPYHRLVPGLLEQIPVLIYAGDADYICNWLGNKAWTEALEWPGQKEYASAEMEDLVIEQNANTGKKIGQVKSHGNFTFMRIYGGGHMVPMDQPESGLEFFNRWLGGEWF
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: SYH_CHLP8
Sequence: MAQLQAVKGTRDIFPDEIARWHYVEGVIRSVAELYGFSEVRTPVFEYTELFQRGIGATTDIVGKEMFTFQPDPNGRSLTLRPEMTAGVMRACLQKNLLSQSPVSKLYYISDLFRKERPQAGRQRQFTQFGAELLGVSNPAAVAEVLTFMMQVFSSLGLHGLRLRINSLGDLDDRARYREALRDYFMPYQNDLDEPSKERLEKNPLRILDSKNPALQEMIAGAPRLYASLKPESVADFEKVLSYLDDRQIAYDVDHLLVRGLDYYCHAAFEVTSSELGAQDAIGGGGRYDGLARELGASNDLPAVGFAVGMERLMIAMEKQGLFATLNPHGPLVYVVVQQKELTDHAMQVAFRLRKSGLKTEIDLAGRSMKAQMRDANRMGAAYALFIGQSEMESGHYALKNLETSEQTSLDLDAIIEVLHEAVSQESARP
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHBP_ECO27
Sequence: METLTAISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAIAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKLVWQR
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: IF2_ZYMMO
Sequence: MSDNDKPKLGMRAPLGIKRTVETSKVKQSFSHGRSNTVIVETKRRRVINKPGSGDAATAAETAKKQAEPVENTPNKDTAVTQTATKNETVATPAAAPAPAPAAAPKPVAAEATAQETSKAAPAAAQPVAEKEAAAPASAEAAKSAAIKVTDRGAKKTTEKNGANASGNRPSGNRSQDNRGRQGGRGSQNKNQTRSGGQPRQPRTLAHRDLASRQELQARLLREAEESRLQALEEARRREDRLKQEADLEEQRRIEEKRRLEAEAKVEAEKQAALKEKEKAEAKARAKAEKEAKAAQAKTAGAAEGEEKTRRPAKAAAPKAREERSESPRSPAPRRFTPVSPPRREAPRPAMRDRKGEDRRQSGKLTVTKALSGDEGGARARSLAALRRAREKDKRANQNRAQQVRQIRDVVVPEAITVQELANRMAERGADLVKALFKMGVAVTLTQTIDQDTAELLVTEFGHNIKRVSESDVEIDSSSDVDPEETLKSRPPVVTIMGHVDHGKTSLLDALRGSDVVRGEAGGITQHIGAYQVESPSGEKITLLDTPGHEAFSEMRARGANVTDIVIIVVAADDGLRPQTVEAIDHARAADVPIIIAINKMDKPEANPQRIREALLQYNVQVEAMGGDVQDVEISAAKKTGLDELIEKILLQAEMLELKANPDRAAEGTVVEAKLDRGRGPVATILVRRGTLKVGDIFVVGEFSGRVRAMTDAQGKNQKEAGPSMPVEVLGLSGVPQAGDTLTVVESEARAREVAAYRAEIALRKRTTAQPASLESMFSALKDKQAVEYPLLIKADTQGSVEAIAGALNKISNEDIRVRILHQGVGGITESDVSLAAASGAPIIGFHVRPNSKARDIARRDGVALKFYDVIYDLIDEIKAAMAGKLGPEYFETVVGKAEIREVFSAGKHGRAAGLLVLEGYIRQKLRARVLRNDVIIYNGSIASLRRFKDDVPEVRAGLECGITLEGSTDIKAGDIVETFEVEERARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO5_SACS2
Sequence: MRGSSNKKIDPRIHYLVPKHEVLNIDEAYKILKELGIRPEQLPWIRASDPVARSINAKPGDIIRIIRKSQLYGEVVSYRYVISG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEMA6_LINSA
Sequence: GCIKTGSFCTLSKGCCTKNCGWNFHCNPPNQ
What is the function of this protein?
Highly potent toxin against both insect and some mammalian sodium channels (Nav) (PubMed:34445875).  It potently inhibits inactivation of insect sodium channels of B. germanica (BgNav1) (EC(50)=2. 6 nM) and also delays the inactivation of mammalian Nav with potent activity on Nav1. 1/SCN1A (hNav1. 1/SCN1A; EC(50)=7. 9 nM, rNav1. 2/SCN2A; EC(50)=24. 3 nM, rNav1. 3/SCN3A; EC(50)=105. 6 nM, rNav1. 4/SCN4A; EC(50)=46. 4 nM, hNav1. 5/SCN5A; EC(50)=215. 2 nM, mNav1. 6/SCN8A; EC(50)=36. 3 nM, hNav1. 9/SCN9A; EC(50)=97. 2 nM) (PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (By similarity).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (By similarity).  In vivo, injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=2. 8 uM) (PubMed:34445875).
What are the official names of this protein?
Nemertide alpha-6.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.
Protein: ADH_DROTS
Sequence: MSTTLTNKNVIFVAGLGGIGLDTSKELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTVPITETTKLLKTIFAKVKTVDILINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPLVSEKLLAHPTQPSQACAENFVKAIELNKNGAIWKLDRGTLEPIQWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HMGC2_HUMAN
Sequence: MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
What is the function of this protein?
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic, 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1, HMGCL-like 1, Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase, er-cHL.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA lyase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: HMT1_YEAST
Sequence: MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs) (PubMed:8668183, PubMed:8647869).  Methylates NAB2, NPL3, HRP1 and YRA1, shuttling hnRNPs involved in mRNA processing and export, facilitating their export out of the nucleus (PubMed:8668183, PubMed:9499403, PubMed:10652296, PubMed:11779864, PubMed:15314027).  Methylation of NPL3 weakens its interaction with THO2, a component of the TREX (transcription/export) complex important for transcriptional elongation and recruitment of mRNA export factors (PubMed:15314027, PubMed:20053728).  Methylates the hnRNP HRB1, but does not influence its subcellular location (PubMed:9499403).  Methylates the nucleolar proteins GAR1, NOP1 and NSR1 (PubMed:12756332).  Methylates the snRNP SNP1 and modulates the cotranscriptional recruitment of splicing factors (PubMed:20823272).  Dimethylates free histone H4 (HHF1/HHF2) at 'Arg-4' (H4R3me2a) and plays a role in preservation and establishment of silent chromatin domains (PubMed:12097318, PubMed:17158743).  Mono- and dimethylates ribosomal protein S2 (RPS2) at 'Arg-11' (PubMed:20035717).  Methylates the catalytic subunit of the SWI/SNF chromatin-remodeling complex SNF2 (PubMed:22997150).
What are the official names of this protein?
Protein arginine N-methyltransferase 1, Major type I protein arginine N-methyltransferase, Type I PRMT, hnRNP arginine N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TACY_STRPQ
Sequence: MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Streptolysin O, SLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).
Protein: PHEB_POLUR
Sequence: MLDAFSRVVVNSDSKAAYVSGSDLQALKTFINDGNKRLDAVNYIVSNSSCIVSDAISGMICENPGLITPGGNCYTNRRMAACLRDGEIILRYVSYALLAGDASVLEDRCLNGLKETYIALGVPTNSTVRAVSIMKAAAVCFISNTASQRKVEVIEGDCSALASEVASYCDRVVAAVS
What is the function of this protein?
Light-harvesting photosynthetic tetrapyrrole chromophore-protein from the phycobiliprotein complex.
What are the official names of this protein?
R-phycoerythrin beta chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=Forms the periphery of the phycobilisome rod.
Protein: PROS_DROVI
Sequence: MSSAAAAAAGAAGGALYTNNNITNNNNNNSNNNNSNITSSSNLSPTAATIATTAAATTATALSGSISPGSRESASSLLSAAFGNLFGGSSGENVKRAVRATNEAGPGCHQWAAQSLDNAMLAAAMETATSADLLNAAGLVSSLNTSKLLNNVNNNNNNNTPLSNGNNNNNNNASISPGSAHSSTTKGGSSRRVSNCSDRSLDGNLAAAATTAATDAAGGSPPRAASVSSLNGGASTQTKQQQLQHDLMAHHMLRNILQGKKELMQLDQELRTAMQQQQQQQQQQQNHEKHQQELHSKLNNNTTTNNNNNVVSESINLIEDSEMPEIKIKSEPELMASATQAPHSPHGGSSNSSSSHSHNSSNNSIASNGSLRRKSSDSLDSMQREERATPATTVEPQLQNEVLPTKKEAVDDMLDEVELLGLSGHGHSRNSDLESLASPSHSDMLLLDNSKDEVLDNDDIIEDDEDDDDDDDDCIETKRESNTSGSNCLKKPGMELKRARVEHIVSSMRCSPSATAQAGQLQVNGCKKRKLYQPQQHAMERYVAAAAGLNFGLNLQSMMLDQEDSESNELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQESECQELDNEHEQDMDSMEQEQEQELEQEQEQEPEPLQQHNDDIELSHSPTLSKSTPKESSERAGSSSPYIEATEQQQLLRAAATMLLPPRPICSLQMMSKMMSSKLQHQHNPLVGVAHPALPQGFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQQQQQQQQQQEQQRRYEQEQEQQRRMEEQQQQLHRQQQHLQQLQQQQQQMEHHVAAAVPRVQLHPPARLPTRMGGAAAAAAAAAHSVLKSELSEKFQMLRQHNSSSNSNNSSSNNNNSNNNSSMMRMSGTDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSVTAAAEQLNKDLMLASQILDRKSPRTKVVADRGLSGNSGHPGAQNGPTPATQSAAAMFQAPKTPQGMNPVAAAALYNSMASPFCLPPDQQQQQQQQQQAAQQQQQQAVQQQHQSAQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILASGWRCAAQWTGSCRSSCCRTTTTTTTTAAAAAATTTAAATEQQWQQQQQQQCNAGTEPNGSRPGRRHILSTATTTTTHDAGVFAHLSGHTKSIAARIQSLFAVQSILQSACGAGPHGPPHGGQPTAAQLHHQHHHQMQLSSSPPGSLGALMDSRDSPPLPHPPTMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMTFDGMQPTISFLKQQQQQQSQLSGAHSVPMVNLWSLAPTHTLGTNVETSWVETALTIITIYHTIYDIYTFSNHCESLTPLHSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVEQTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQLE
What is the function of this protein?
Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding.  Not required for the specification of neuronal identity.  May regulate transcription by binding to DNA (By similarity).
What are the official names of this protein?
Homeobox protein prospero.
What is the protein family that this protein belongs to?
Belongs to the Prospero homeodomain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPB_BURTA
Sequence: MPPASDAHAAPDAAASTSASPQSCAAPPDTLPVTVRWLGETPYDACFDAMRAFTDARTPDTGDEIWVVEHPPVYTLGQAGNPAHLLVADSGVPLVKVDRGGQITYHGPGQIVAYLLIDLRRRKLMVRTLVTRIEQAVIETLAAYNLASVRKAGAPGIYVESGPHHGAKIAALGLKIRNGCSYHGLSVNVKMDLRPFLAINPCGYAGLETVDMASLGATADWHEVARTLVRRLIANLDGATAAAALPQQALEQSND
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RICTR_SCHPO
Sequence: MKPVRRGQTDTALDISSHAKTNGDFIKKMNTTDSKRLKLLEDLKGKLEVECKIRDGAETLLQVFDTNFKKETKERKEMLKKKCTDELESSKKKIEELVSSIESFQGENGEAKTGSTSLTRSASATVSRKSSLQEKYSTRFSYKAGCSDSCSVTVSGTGELIGPTRNAHSNLTPTVIQRIDFENVNEKNNSSSEDTQPNGKRPSSLQSNFSQFPLNPWLDNIYKACLEGSMKDVIDSSNNLCEYLHEHSDPAYAKNFSLITPTILSMLELNVSEVTASVYRLLRHLFLDATAFSCCQMLNLPWILSKSLLSGTDAYQIEREQAFRLIRTLYFLSSTEGHEDYLSGITRTIISICEHVSDVSRGIAVETLIELMIIRPKILFKANGLRVLMISLIDGSISENLAASAALALVYLLDDPESACYVNLPYDIGILLSPFTSSSSRDTFNSSEEQSEQAAKAMKSSAKVASVLLNSWSGLLALSTNDFQALRSIVDTLRVPSFAPRSDVIDLFFLIFQVEYSSWSESFLAGKRLTVVKNQAVSNDDNINMVNIPDGSNKKYMSLRQHFTAVLLFIFLELGLVESIVCMIRASDDPSASRKATYLLGEVLRLSDELLPIHLGAKIQSLPSLFNMASQFTAEDRFVATSVLQSIESLNRVKFHSATQPFSQTTSLLFKEQKTDGSFRGQRQVEHVKLKMGMQIDDSHFRSMLAETNVLATKNYQKWRWDTLVQIMEGPLLSPKRIDETLRTTKFMRRLLAFYKPFSNRFSSIQNTKPNQKFIKVGCLVFRTLLANPEGVKYLSESKVIKQIAESLSQIDGYSEQVSEPIFSNSRLQKTLTHGYFPMLKVLSSQKEGHAIMERWRIFTTLYHLTELRNRDDLIIIFLTNLDYRLEGHTRIIFSKALNTGQQAVRLTATKHLAALINSESANDNLNHWAISLLIFQLYDPCLEVCKTAVKVLNEVCARNENLLAQVVQLQPSLAHLGEIGSPLLLRFLATTVGFHYLSEINFIEHELDNWYHHRNIDYVDLLEQNFFLSFVSNLKIIDKKNNEPDENILPLHFYGELVKSPQGCEVLESSGHFESFMGTLVEFYDKPLGNEAIRQLKSALWAIGNIGKTDQGITFLINHDTIPLIVKYAENSLIPTVRGTAYFVLGLISRTSKGVEILESLHWYSLMSLMGTSQGICIPRHAGQVLSTPRRNVEFVNERVPTPEFSSLLSSLTNSEREVIRLVSNLSNHVLTNESARQLTKIRSKNAKVFSSKRLVKACMTILGKFHYRVQIQQFVFELFPYSVLLSSSTSQDLNESPSRPNNLSISA
What is the function of this protein?
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals.  TORC2 is required for cell survival under various stress conditions.  TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake.  Positively regulates amino acid uptake through the control of expression of amino acid permeases.
What are the official names of this protein?
Target of rapamycin complex 2 subunit ste20, TORC2 subunit ste20.
What is the protein family that this protein belongs to?
Belongs to the RICTOR family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL21_KARMG
Sequence: MEAIFELLGYQYKASLNWDIYIPLLKGYNKGKNIFIKKILFIKNNGLIINGFPYINRGIIKAKIIKHIRDKKQICFKSKKRKGFKLKKGHRQYLTKIKIIYIEF
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: IOD2_LITCT
Sequence: MGLLSVDLLITLQILPGFFSNCLFLALYDSVVLVKHVLLQLNRSKSSHGQWRRMLTPEGLRCVWNSFLLDAYKQVKLGGDAPNSNVIHVTDKNSSSGKPGTPCHLLDFASSERPLVVNFGSATUPPFISQLPAFSKMVEEFSAVADFLLVYIDEAHPSDGWAAPGISSYEVKKHRNQEDRCAAANKLLEQYSLPPQCQVVADCMDNNTNAAYGVSFERVCIVQRQKIVYLGGKGPFFYNLQEVRQWLELTFGKKAESGQTGTEK
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).  Is responsible for the majority of the intracellular T3 in tissues such as the pituitary, brain and brown fat by mediating local deiodination of T4, and is important in regulating thyroid hormone action in these tissues.  Plays a major role in development.
What are the official names of this protein?
Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FERT_TOBAC
Sequence: PFNVGGLDKFGTLN
What are the official names of this protein?
Feruloyl-CoA thioesterase.
Protein: RE114_MOUSE
Sequence: MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN
What is the function of this protein?
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721).  Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).
What are the official names of this protein?
Meiotic recombination protein REC114.
What is the protein family that this protein belongs to?
Belongs to the REC114 family.
Protein: SMG_ALISL
Sequence: MMDVLMYLFETYIHSDIELTVDQEKLEDELLKAGFHQEAIYKALDWLEDLAHLQETDSHEHIAKSTSTAMRIYTQQEIDGIDTVCRGFLLFLEQIKVLTCETREMVIEQVMTLETEDLSLDDLKWVILMVLFNVPGQESAYTQMEELLYTSDTGMTH
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: MT3_PICGL
Sequence: MSSDCGNCDCADKSQCTKKGFQIDGIVETSYEMGHGGDVSLENDCKCGPNCQCGTCTCHT
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein EMB30.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.