PharMolix/UniProtQA huggingface dataset:
Protein: DNJ1_FUSO4
Sequence: MHLNLAGLAVAATAFLATASALSPQDIPADLPVSNLLTKAQTHLSRGETNEALVYYDAAIARDPTNYLSLFKRATAYLSLGRTSQATEDFNKVLSLKPGFEGAHLQLARLRAKAGDWDAAKAQYGLAGKAPKSAEFVELEEAKLAAHLADMASKGGKWEECVSHAGTAIVVASRSPHLRELRAHCRFELGDVELALSDLQHVLHMKPGDTSPHIVISATSFYALGDLENGIGQVKKCLQSDPDSKICKKLHKQEKKVEKAYKKIQGQLSRGQPTTAGRALVGTADDSGLVPDVRKQVEELKKNKSIPKTARIQLLENLIEMTCQAYTESSHKEAAKYCDESLQLNPDSFWGLLHKGKAQLKSELYDAAIATLEKAAEIRPDQKEKVNPILNKAHIALKRSKTKDYYKVLGVENDADERQIKSAYRKQSKIFHPDKAAKQGIPKEEAEKKMASINEAYEVLSDPELRARFDRGDDPNSQERPNPFQGQGNPFGGGHPFMFQQGGGGGGPNIKFQFGGQPFGF
What is the function of this protein?
Endoplasmic reticulum co-chaperone required for the of virulence factors such as PG1, the major endopolygalacturonase produced during the infection of tomato plants.
What are the official names of this protein?
Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: GRPE_SYNE7
Sequence: MSEHQTPPEEDLTVANGDSAEAVSEPDVTVASGQEAAELAAQLALVAADRDRLKTELDEQNSAYLRLAADFENFRRRTLKEREELELQSKRTTITELLPVIDNFDRARAQIKPQGEEAEAIHKSYQGLYKQLVDCLKRIGVSPMRAEGQPFDPSLHDAVLREETTEHPDGIVLEELQRGYLLGDLVLRHALVKVSIAAEENSAAVTE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRH4_EMENI
Sequence: MNRLGGLSLPLRPVCLFCRAQTSLALSPLQGGQAVRSIATGRLRRRARMTLSKDVAKSSLKPKRTDRGKLGPFPNMNQTRARVREDPRSRSPAALKRSGETEEKPAMNTESPLYKALKMQTALAPISYGKRTAIKAKIAEITSFDAFTLLPIVRNSIFSQALPGIADAVPTPIQRVAIPRLLEDAPAKKQAKKVDDDEPQYEQYLLAAETGSGKTLAYLIPVIDAIKRQEIQEKEMEKKEEERKVREREENKKNQAFDLEPEIPPPSNAGRPRAIILVPTAELVAQVGAKLKAFAHTVKFRSGIISSNLTPRRIKSTLFNPAGIDILVSTPHLLASIAKTDPYVLSRVSHLVLDEADSLMDRSFLPISTEVISKAAPSLQKLIFCSATIPRSLDSQLRKLYPDIWRLTTPNLHAIPRRVQLGVVDIQKDPYRGNRNLACADVIWSIGKSGAGSDEAGSPWSEPKTKKILVFVNEREEADEVAQFLKSKGIDAHSFNRDSGTRKQEEILAEFTEPAAVPTAEEILLARKQQQRENINIPFVLPERTNRDTERRLDGVKVLVTTDIASRGIDTLALKTVILYHVPHTTIDFIHRLGRLGRMGKRGRAVVLVGKKDRKDVVKEVREVWFGLDS
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase mrh4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GAL1_THENN
Sequence: MRVKAPGRINIIGEHTDYNDGYVLPFAVNRFVFLTIEDSGKFVFHSENMNETVEMEKIEKLNRWTDYISGVIKAFEKRGYKVSPVKISVSSNLPMGAGLSSSAALEMATAYAISEHFGFHLPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYVPLKLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLRVLGKRSFREVTKEDLKKLPDVLKKRAQHVLEENERVLKSVQALKEGDFETLGRLLFSSHESLRDLYEVSCEETDFIVDFLKGREGILGARMVGGGFGGGVIVLSKKGAFEKIKEELKNAYRDRFKIELTFHEIESADGVQKI
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEA_NEIMB
Sequence: MPILTIREVCNINHWGIGYYDVDDSGEIIVRPNPSQHNQTVSLQKLTEAVQQKHQARLPVLFCFPQILEHRLRDINRAFQTAREECGYKGGYCLVYPIKVNQHRRVIESLMSSGQPHGLEAGSKAELMAVLAHAGNRQTLIVCNGYKDREYIRFALMGEKLGHQVYLVIEKLSEIQMVLEEAEKLGIKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLQLVDILKQKNRLDCLQLLHFHLGSQLGNIRDVATGVHESARFYVELHKLGVNIRCFDVGGGLGVDYEGNRTQSDCSVNYSLNEYAATVVWGISQACLEHGLPHPTIITESGRGITAHHAVLVANVIGVERYKPRRLDAPSPEAPRVLHSMWETWTDISASREKRSLRSWIHEGQFDLADVHNQYNVGLLSLAQRAWAEQLYLNICHEVGELFNEKHRSHRTIIDELQERFADKLYVNFSLFQSLPDAWGIDQLFPVCPITGLNEPIARRAVLLDITCDSDGTIDHYIDGDGIAGTMPMPDYPEEEPPLLGFFMVGAYQEILGNMHNLFGDTATADVVVGEDGQFTVIDYDEGNTVADMLEYVYQDPKELMKRYREQIEHSDLPASQAMSFLKELEAGLNGYTYLEDE
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: HEMH_PSEPF
Sequence: MTDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSRRLQQQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRITLAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFYDQPEYLDALVASARPHLQQDYDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERMGLPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGDRGKEQFREAGGEELVLVPCLNDDPQWAKALATLCERAPLAL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_CAMJ8
Sequence: MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLYPDDSMIELKSTLAQKYKVQNENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCLPNNPLGECLDASEVTKFIKGVDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIANANIINAFYKLRAPFNVSNLALKAAVAAIDDDEFTKKTLENNFSQMQLYKEFAKKHNIKIIDSYTNFITYFFDEKNSTDLSEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFDKILR
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: TRAM7_ECOLX
Sequence: MAKVNLYISNDAYEKINAIIEKRRQEGAREKDVSFSATASMLLELGLRVYEAQMERKESAFNQAEFNKLLLECVVKTQSSVAKILGIESLSPHVSGNPKFEYANMVEDIREKVSVEMERFFPKNDDE
What is the function of this protein?
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell.  It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations.  Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site.  Probably autoregulates its own expression.  Plasmid specificity is conferred by the TraD-TraM pair (By similarity).
What are the official names of this protein?
Relaxosome protein TraM.
What is the protein family that this protein belongs to?
Belongs to the relaxosome TraM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI24_MOUSE
Sequence: MADSVKTFLQDLGRGIKDSIWGICTISKLDARIQQKREEQRRRRASSLLAQRRPQSVERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSSSAEKFPSPHPSPAKLKAAAGH
What is the function of this protein?
Acts as a negative growth regulator via p53-mediated apoptosis pathway.  Regulates formation of degradative autolysosomes during autophagy (By similarity).
What are the official names of this protein?
Etoposide-induced protein 2.4, p53-induced gene 8 protein.
What is the protein family that this protein belongs to?
Belongs to the EI24 family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MURC_DESVH
Sequence: MKNKVRTIHMVGIGGSGMSGIAEVLLNLGYAVHGSDMSDSAVVRRLRKIGAEIFIGHGAGNVSDAEVLVKSTAVRDDNPEVLAAVEKGIPIIPRAEMLAELMRLRTGIAIAGTHGKTTTTSLTAAIFDVAGKDPTVIIGGRLNAYGANARLGEGEYLIAEADESDGSFLCLFPIVNVVTNVDMDHVDFYAGQKEIDEAFVTFMNKVPFYGANVVCGDDPGVRRLLPQVKRRVVTYGFGKDNALRAEVTSCAETSVFTVFLRGGRLGEVHLGQPGRHNILNALAAIGVALEAGISPEHCIEGLARFGGVGRRFERRGERDGVTVVDDYGHHPVEIAATLATARSVYPDRRLVVVFQPHRFSRTQALFGEFCKVFEPVDKLLLTEIYPASEKPIPGVSGQSLAQGIRQVSNTDVTYYQSFDEILAALPGVLRPGDVLLTLGAGSVTTIGQRYVAGE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPNP_ORYSJ
Sequence: MSQAAGNPYAAELAAAKKAVTLAARLCQAVQKDILQSGVQSKADQSPVTVADYGSQILVSLVLKMEAPASSSFSMVAEEDSEELRKEGAEEILENITELVNETIVDDGTYSIYFSKEGILSAIDDGKSEGGPSGRHWVLDPIDGTKGFLRGDQYAIALALLDEGKVVLGVLACPNLSLGSIGNLNGGSSGDQVGALFSATIGCGAEVESLQGSPAQKISVCSIDNPVEASFFESYEGAHSLRDLTGSIAEKLGVQAPPVRIDSQAKYGALARGDGAIYLRFPHKGYREKIWDHAAGSIVVTEAGGLVTDASGNDLDFSKGRFLDLDTGIIATNKQLMPSLLKAVQDAIKEQNQAASPL
What is the function of this protein?
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.  Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity).
What are the official names of this protein?
3'(2'),5'-bisphosphate nucleotidase, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, DPNPase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
Protein: OMT_ASPNA
Sequence: MGQSHLDIGVGTGYYPAKSLKAGAKCTEITLLDLSPNSLQATEQRILETVGREAVRVNTVVASALEPLPFDKAKKFNSISVFFLLHCMPGTPEEKCKLFDVVRPHLAEDGVLVGTTVLGQGVPINWLGQKMMNSYNNNTKSFHNSEDNKAQFDEGLRRNFEEVDSWIMGQVMLFKARKPRQQDAITNVVPKDNLD
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of pyrophen and campyrone B, which represent a class of fungal amino acid-derived alpha-pyrone natural products (PubMed:32159958).  The first step of pyrophen biosynthesis is catalyzed by the PKS-NRPS hybrid synthetase ATPKS that uptakes and condensates L-phenylalanine and malonyl-CoA in order to produce desmethyldesacetylpyrophen (PubMed:32159958).  Although the A domain does not discriminate between 2 enantiomeric phenylalanines, the downstream KS domain must play a gate keeping role to stereoselectively accept the L-phenylalanyl-S-phosphopantetheine (Ppant)-T domain intermediate for chain elongation (PubMed:32159958).  The resulting amino acid derived diketide is off-loaded through lactonization to yield the alpha-pyrone intermediate desmethyldesacetylpyrophen (PubMed:32159958).  The cluster-specific O-methyltransferase (OMT) then methylates desmethyldesacetylpyrophen to desacetylpyrophen, which is further acetylated to pyrophen by an endogenous yet unidentified N-acetyltransferase (PubMed:32159958).  ATPKS has relaxed substrate specificity to activate and extend branched-chain amino acid L-leucine to produce small amounts of campyrone B (PubMed:32159958).
What are the official names of this protein?
O-methyltransferase, OMT, Pyrophen biosynthesis cluster protein OMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: DCAM1_DIACA
Sequence: MMVPTLGNSNYNTVSPMNGDDNNTMALSAIGFEGFEKRLEISFFEPGIFVDPEGKGLRALSKAQLDEILGPAECTIVDSLANESVDSYVLSESSLFVYSYKIIIKTCGTTKLLHSILPILTLADGLCLDVKSVRYTRGSFIFPGAQSYPHRSFSEEVAVLDKYFGNLGTGSKAFVMGSPAKPQKWHVYSATAEPSYDDPVYTLEMCMTGLDKGKASVFFKSESASAAVMTETSGIRKILPDSAICDFDFEPCGYSMNAIEGPAVSTIHITPEDGFSYASFEAVGYDLKIVDVNQLVERVLNCFQPREFSIAVSVDTADKVLEQYCAVNVAGYCREEGGVEGLGVGGSVLYQKFGKVATVSGLNKSPKCCRKEEENDEKREC
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme 1, AdoMetDC 1, SAMDC 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: RK36_SACHY
Sequence: MKIRASVRKICTKCRLIRRRGRIRVICSNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GSA_METMP
Sequence: MELNIKMDRSKELFEESKKYLVGGVNSPVRLFKPFPFFVKSAKDCFLYDEDGNEFIDYCLAYGPMVLGHANENILNAVKSQMDLGTAYGVPSEKEITLAKEVINRIPCAEMVRFVNSGTEATMGAIRLARGVTKRNKIIKFEGAFHGAHDYVLVKTGSGALTHGAPNSPGIPEDTTKNTLLIPFNDEEAVRKVISENKEEIACIILEPVMGNVGCIPPKDGYLQFLREITEENGILLIFDEVITGFRLSKGGAQEYYGIKSDLATVGKILGGGFPIGAITGKKEYMEQFSPNGQIYQAGTFNGNPISVTAGIETLKNLDDKFYKETTKKAGILSNCLRETAEKYNIPAKVYNVASIFQVYFNDKEIVTYEDAKSSDTEKFMKYFYTLLENGVFVAPSQFECCFTSIKHNDEVLEKTMNAIDIAMKKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_STAAB
Sequence: MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESATSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSMTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: K1B1_BUNCI
Sequence: ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
What is the function of this protein?
Inhibits voltage-gated potassium channels (IC(50)=405. 0 nM for rKCNA1/Kv1. 1, IC(50)=0. 03 nM for rKCNA2/Kv1. 2, IC(50)=1. 31 nM for rKCNA6/Kv1. 6, IC(50)=74. 11 nM for hKCNA3/Kv1. 3, and IC(50)=247. 69 nM for insect Shaker IR).  Binds the Shaker IR channels in a voltage-independent manner.
What are the official names of this protein?
Kappa-actitoxin-Bcs3a, Kappa-AITX-Bcs3a, Potassium channel toxin BcsTx1, BcsTx1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1b subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: DBP3_VANPO
Sequence: MSKDEIKDKKRKSEEYEVVDKKKHKKDKKDKKEKKDKKEKKLKKDKKDKKDKKETKSESESNEDNESVASVSTSSTVDGYTENADLLKVPQSEIDEFFTTNEVAVEDESKLNLRPLLSFSHISLDSRIQAEISKFPKPTPIQAVSWPYLLAGKDVIGVAETGSGKTFAFGVPAINNILTKSGSKPGKNGIQVLIISPTRELASQIYDNLVILTDKVGLECCCVYGGVPKDEQRTQLKRSQVVVATPGRLLDLIQEGAANLSNVNYLVLDEADRMLEKGFEEDIKNIIRETKSTGRQTLMFTATWPKEVRELASTFMNSPIKVSIGNTDELSANKRITQIVEVIDPFKKERKLLELLKKYQSGSKKDDKVLIFALYKKEAARVERNLNYNGYKVSAIHGDLSQQQRTNALDEFKTGRSSILLATDVAARGLDIPNVKTVINLTFPLTVEDYVHRIGRTGRAGKTGTAHTLFTEQEKHLAGSLVNVLNGAGQPVPEELKKFGTHTKKKEHSAYGAFYKDVDMTKKAKKITFD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CLD18_BOVIN
Sequence: MSTTRCQVVGFLLSILGLAGCIVATEMDMWSTQDLYDNPVTAVFQYEGLWRSCVQQSSGFTECRPYLTILGLPAMLQAVRALMIVGIVLSVIGLLVAIFALKCIRMGNMDDSAKAKMTLTSGIMFIIAGLCAIAGVSVFANMLVTNFWMSTASMFTSMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVLMCIACRGLAPEETNYKAVSYHASGHNVAYRPGGFKASSGFESNTRNKKIYDGGARTEDEGQSPPSKYDYV
What is the function of this protein?
Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity).  Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity).  Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity).  Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity).  Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity).
What are the official names of this protein?
Claudin-18.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells.
Protein: EFG_ORITB
Sequence: MSENHKLSYVRNIGIGAHIDAGKTTTTERILYYTGVSYSIGEVHDGTTVMDYMKQERDRGITIQSAATTCHWIKKDDCAEQASQKEQEYKINIIDTPGHVDFTIEVGRALRVLDGMIAVFDGVAGVEPQSETVWRQADKYAVPRICFVNKMDRIGADFFRCVQMMKDRLGTKPLVIQLPIGIEDTFKGVIDLVKMKAIVWSNEDLGAKYEYHSIPSNMHAMVEDYRHQLLETVVEVDEEIFNSYVSNEDLSEADIRKCIRKGAISGLFVPVLCGSAFKNKGVQTLLDAVVDYLPSPNDVNSIKAVDVKTEQEISRKVSVDEQFSALAFKVINDPFVGSLTFIRIYSGKLQTGSTVINTTKNQKERISRMLLMHANNRKDIKEAVAGDIVALTGLKSTTTGDTICSLDSQIILEKIEFPKPVIELAVEPKTPADQEKISAALVKLAAEDPSLVFTVDSETNQMVIKGMGELHLEIIIDRMKEEFKVEANVGAPRVAYRETITQSYTVDYTHKKQTGGAGQFARVKIIFEPLEVGAGFQFESKIVGGAIPKEFIPGVEKGLEEIKESGVVAGYPTIDFKATLIDGSFHEVDSSVLAFEIAAKNAFKEGITKAGPKLLGPIMKVEVISPNEYMGDIIGDLNSRSGVIQSMEPRGNTQIINAYVPLGQMFGYVSTLRSLSQGRAQYSMVFSHYEQVSRSIAEKIQAKDKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_GEOMG
Sequence: MKEQLDGLLQSALKEIDGAGSEEALQELRIKYLGKKGALTAVMKGLGALSAEERPVVGQLANTVKDQLEAHLDETLAQVRDASKRERLQRERLDVTLPGRRLPHGTKHPITLVIEEISEIFAGLGFRVAEGPEVELDFYNFEALNFPKDHPARDMQDTFFVDDSILLRTHTSPVQVRTMLKHAPPVRIISPGTVYRCDSDATHSPMFHQIEGLMVDTGVTFGDLKGILTNFVNQYFGKGIGVRLRPSFFPFTEPSAEVDIACVMCKGKGCRVCKESGWLEILGAGMIDPEVYRHVGYDPETISGFAFGMGVERVAMLKYGIGDLRLFFDNDVRFLQQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_STRU0
Sequence: MAEKTYPMTKAEKEQLEKELEELKLVRRPEVVERIKIARSYGDLSENSEYDAAKDEQAFVEGQISTLETQIRFAEIIDSDAVAKDEVAIGKTVVVQEVGTTDKDTYHIVGSAGADIFSGKISNESPIAQALIGKKKGDIADIVSPATTYQVEIISVEKTK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: FHUD_ECOLI
Sequence: MSGLPLISRRRLLTAMALSPLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVADTINYRLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSPEMLARIAPGRGFNFSDGKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKDMDALMATPLWQAMPFVRAGRFQRVPAVWFYGATLSAMHFVRVLDNAIGGKA
What is the function of this protein?
Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import.  Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease.  Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.
What are the official names of this protein?
Iron(3+)-hydroxamate-binding protein FhuD, Ferric hydroxamate uptake protein D, Ferrichrome-binding periplasmic protein, Iron(III)-hydroxamate-binding protein FhuD.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CREA_ECO57
Sequence: MKYKHLILSLSLIMLGPLAHAEEIGSVDTVFKMIGPDHKIVVEAFDDPDVKNVTCYVSRAKTGGIKGGLGLAEDTSDAAISCQQVGPIELSDRIKNGKAQGEVVFKKRTSLVFKSLQVVRFYDAKRNALAYLAYSDKVVEGSPKNAISAVPVMPWRQ
What are the official names of this protein?
Protein CreA, Catabolite regulation protein A.
Protein: SGO1_YEAST
Sequence: MPKRKIAPNKESSRRTVSHDDLTPQIQEFQNLMDLESQKVENIRQSYSRQNSLLAKDNSILKIKVNSLEKKISQLVQENVTLRSKTSISEAIYRERLSNQLQVIENGIIQRFDEIFYMFENVRKNENLPSSSLRTMLKRTSSRSRSCSLSSPTYSKSYTRLSNHENNLSHESSFNKDDGPDLEPKAKKRKSSRRQSMFVSTSLEPEDETGENEPMMENSSVEVPAESHESAQVEETIDALNPEEENSDSVSNFTNSIIEYSIPEENPTEPEHSSSKLEIFNDSTNMLSTVPSNPLPLPLPGPSATLPTTTSDASTVYPSSSSSTNSHPKTKIKHSMKPPRIELKKKVIDEVMPVSNMSSNSEISFTRTRRTRGKAVDYTLPSLRAKMRRPSEKLVDATTVIDIHDLQVSKRNRETSHKRKSLSQDSIPDEPQLREVVVSKDYGTPKGKKTEDEIHEDTAHLMTTSNNNSNNKNEKKLTSNNSPKKSSPLLDITNKSENKKKSTRTKKLFKNAIVNNLSDENSTTRPSKSSKGTSNNNNNYNNFDNNNSNINNVNNKSVSFRLNEDDLAVFDLFGNGKAVKHQPKTYRTKK
What is the function of this protein?
Plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.  Probably act by protecting REC8 and RAD21 from separase degradation during anaphase.  Also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension.
What are the official names of this protein?
Shugoshin.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the centromere during S and M phases, dissociates at the onset of anaphase. Colocalizes with kinetochores. Associates with the spindle pole.