PharMolix/UniProtQA huggingface dataset:
Protein: CCZ1B_ARATH
Sequence: MGMASMSSGTESLRLCVFDLRRGQHEGQELDKILFFYPPDLTFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMIVEKNKEIEAVWRIDALRRVLKEVHSLFVMFQGSIRALLEKEPTGGLVRSHLYPFITDYLNDLFVGKKQQLPSFRDTLKERGTVQMLTLARDAALEVQSLVGVLDSCAGTVRCHSVILFHDLLVSTTLSPDDTVDLFAFSVMRLTTNALSSGTSSWSYLRKGSGSPQISSRSTTVPPLGSGGTLPSGNGSSTGRVIRPLQHDKWSKGKDGFLVTDIWGLDATPTILIQKTQESFYLLTYQYKSLTLVLLVPIAAIVNGELDISFVKQQVIENASTKILKVEEKLSKGWGGENAYHVSGYRYLLVDNDMEVSRASPPGKVATLAKESLLALNKLREEVDTEKNRSKQEKDMEICIRAKNNTWVIARLNRGKELYMALEKASETLLDATDSVQRFSNRYCSGAFPMD
What is the function of this protein?
Plays an important role in membrane trafficking through the secretory apparatus.  In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the RAB7 protein family.  Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form.  The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles.  May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
What are the official names of this protein?
Vacuolar fusion protein CCZ1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the CCZ1 family.
What are the subcellular locations of this protein?
Endosome. Prevacuolar compartment.
Protein: RL14_STRSV
Sequence: MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKSGARRKDGSYIKFDENAAVIIREDKTPRGTRIFGPVARELRDGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PSG11_HUMAN
Sequence: MGPLSAPPCTEHIKWKGLLLTALLLNFWNLPTTAQVMIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETVYSNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPREAMETVILTCNPETPDASYLWWMNGQSLPMTHRMQLSETNRTLFLFGVTKYTAGPYECEIWNSGSASRSDPVTLNLLHGPDLPRIFPSVTSYYSGENLDLSCFANSNPPAQYSWTINGKFQLSGQKLFIPQITPKHNGLYACSARNSATGEESSTSLTIRVIAPPGLGTFAFNNPT
What are the official names of this protein?
Pregnancy-specific beta-1-glycoprotein 11, PS-beta-G-11, PSBG-11, Pregnancy-specific glycoprotein 11, Pregnancy-specific beta-1-glycoprotein 13, PS-beta-G-13, PSBG-13, Pregnancy-specific glycoprotein 13.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRF2M_DROGR
Sequence: MLQYCLLRRYRFLLRQHAQVIKRCYSGDIRNIGILAHIDAGKTTTTERMLFYAGKTRSLGEVHRGNTVTDYLAQERERGITICSSAVTFNWNGKRINLLDTPGHIDFTMEVEQSLYAVDGVIVVLDGTAGVEAQTVTVWTQADKHKLPRLVFVNKMDRPDANFEKCIVDLTEKLDAKPICTQYPTKSADGQLGIFDVITMEQMTWQQNDLGRNYSKVKLESSTELQEKRNELIDQLSGLDDELADVVISTESFDKVSNELIGQALRRATCQQKVVPVLLGSAYKNIGIQPLMDAVNAYLPMPEERNQMYDCFGNDFAGKVFKIVHDKQRGPLTLVRLLRGELKRGMRLLCSARGQAEVVSKIYEPLADEYREVGSMQAGDVAICAGLKSTVTGDLLTSSHTSLKNAQKRLLQSRGAAMPQDEDEVLDDASHELFSIEPKIPDAVYFCSIEPPSISSQTAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGELHMDIIKSRMLSEYKIDVDLGPLQIAYKETLGSSAITTLSVDKDIAGSKQSVSITLQLVSDQRELFSLDKSPENVQHLNALRPRILGVLRKGAVSALERGPRVGGQVVDTQIRLHNVTVGRGTADSFVMAAAAQCVQKLLITSGTRLLEPIMAIQIVAPNERISGIMADLSRRRALIRDVTSKGDRNKIILVNAPLAELSGYSSALRTISSGTASMTMQPCGFSEMNTADESLAVRRAQGLD
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MDH_RHIME
Sequence: MARNKIALIGSGMIGGTLAHLAGLKELGDIVLFDIADGIPQGKGLDIAQSSPVEGFDASLTGASDYSAIEGADVCIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPNAFVICITNPLDAMVWALQKFSGLPKNKVVGMAGVLDSSRFRLFLAEEFNVSVKDITAFVLGGHGDTMVPLARYSTVAGIPLPDLIQMGWTTKEKLDQIIQRTRDGGAEIVGLLKTGSAYYAPAASAIEMAEAYLKDKKRVLPCAAHLSGQYGVKDMYVGVPTVIGAGGIERIIEIDLNKGEKEAFDKSVAAVAGLCEACINIAPSLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: LEU1_BRASO
Sequence: MSNPVQSDKDRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKALADRKKQIYDEDIEALIDEGMVSAHDRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEESEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQRDVAPGHGASAAAAS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: FAL1_EMENI
Sequence: MADGIDRRADDKMEFNTSKEVTVAPTFEDMHLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISALQVIDTVVRETQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNIGEDIRKLDYGQHVVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRVLVKRDELTLEGIKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTSDDVRILRDIELYYSTQIDEMPMNVADLLS
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase fal1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL24_DEHMB
Sequence: MRLKKNDNVLVIAGKDKGKTGKVRYAYPRTDRVLVEGVNMIKRHSRAKGQAKQAGIIEREAPLHVSNLMLLCSKCNKPARIGSRELADGKSVRYCKSCNEVID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LEPA_PORG3
Sequence: MKNIRNFCIIAHIDHGKSTLADRLLEYTNTVSGKDLQDQVLDNMDLERERGITIKSHAIQMDYEMDGEKYVLNLIDTPGHVDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIENDLTIIPIVNKVDLPSAMPEEVEDQIIELLGCDRSEIIRASGKTGQGVDQILRAIVEQVPAPAGDPDAPLQCLIFDSVFNPFRGIIAYFKVVNGSIRKGDHVKFIATEKEYDADEVGVLRLDMEPRSEVKTGDVGYIISGIKTSREVKVGDTITHVAKPAKEAIAGFEEVKPMVFAGVYPIEAEDFENLRTSLEKLQLNDASLTFQPESSVALGFGFRCGFLGLLHMEIVQERLDREFNMNVITTVPNVSYKVYDKKGGCKEVHNPSGLPEPTLIDHIEEPFIRASVITNTAYIGPIMTLCLGKRGVLVKQEYISGDRVEIFYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRESKLVKLDILLNGEPVDALSTLTHVDNSVTFGQRMCEKLKELIPRQQFEIAIQAAIGAKIIARETIKPVRKDVTAKCYGGDISRKRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DF117_ARATH
Sequence: MTTTKTMLVAFVLTLFFVISSVHCSDGTSGYGITEATKRCFTPAPCTRGLFYCQTFCSSLSAVLIGVCESGICCCILNQ
What are the official names of this protein?
Defensin-like protein 117.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SURE_ECO57
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXC4_ORYLA
Sequence: MIMSSYLMESNYIDPKFPPCEEYSQNNYIPDSPEYYSRARDTGYQHHHQELYPPRASYQERQYNCASIPEPDTPRGHGIPHSAHLLAGKGQPASCETPQLSMSPATPPAAASACNQATPEHPNSTASSKQPVVYPWMKKIHVSTVNSGYNGTEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDHRLPNTKVRSSSSGSNTSSAAGGVAAASATNSGPDELSGAQHGEDITRL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YHAM_BACCZ
Sequence: MKKKIAEYEVGEQVDIFLLIKTATKGIASNGKPFLTVILQDPSGDIEAKLWDVSPEVEKQYVAETIVKVAGDILNYKGRIQLRVKQIRVANENEVTDISDFVEKAPVKKEDMVEKITQYIFEMRNPNIQRLTRHLLNKHQNEFLDYPAATKNHHEFVSGLAYHVVSMLDLAKAISNLYPSLDKDLLYAGVILHDLGKVIELSGPISTTYTLEGNLLGHISIMVNEIGKAADELQIDAEEVLILQHIVLSHHGKAEWGSPKPPLVKEAEILHYIDNLDAKMNMMDRALGRTKPGEYTERVFALDNRSFYKPSFHN
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: ZBED3_MOUSE
Sequence: MKSKKPLKITMEDSRRLNDPAEQGGLCPAPVGPSYSEAWGYFHLDPAQPRHRMMSAWATCRLCGLQVGGLPNFQMWTRALCQHLSDVHLPELKKSAAPSSPTTMPCPPPPSPTMAAEGDWARLLEQMGELAMRGSQRELELERREAALMQAELELERKRQALKQEAQSVEQERHQLQVEREALSKWIKKQSPGAQVPEPPSPLPLLPKEDPDIHDNNSDNDMVTKVLL
What is the function of this protein?
Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (PubMed:19141611).  Involved in transcription activation of Wnt target gene expression (PubMed:19141611).  Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (PubMed:28992324).  Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (PubMed:28992324).
What are the official names of this protein?
Zinc finger BED domain-containing protein 3, Axin-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Secreted. Note=Colocalizes with AXIN1 in the cytoplasm (PubMed:19141611). Colocalizes with NLRP5 in the oocyte subcortex (PubMed:28992324).
Protein: RHMD_ECO45
Sequence: MENIMTLPKIKQVRAWFTGGAIAEKGAGGGDYHDQGANHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLVVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLNATLYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGEDFWLMLDCWMSQDVNYATKLAHACAPYNLKWIEECLPPQQYEGYRELKHNAPAGMMVTSGEHHGTLQSFRTLSETGIDIMQPDVGWCGGLTTLVEIAAIAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTMRPQFDPILLNEPVPVNGRIHKSVLDKPGFGVELNRDCNLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: YTDA_BACSU
Sequence: MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELKESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPYAKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETKTEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEADSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ
What are the official names of this protein?
Putative UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: MCM5_CAEEL
Sequence: MSNLDNPGIYYQERFFANDGVPDTGRELIAEYRQLITQFRNFIRDFSTGGFGMIYRDQLKRNYFSHEYRLEINLNHLKNFDEDIEMKLRKFPGKVLPALEEAAKIVADEITTPRPKGEEKLHDIQVTLTLDEYPTSLRQVKSAQVSQVVKISGIIVAAAQVRSKATKVTLQCRQCKHTIPDVSIKPGLEGFALPRTCAAPQQGQMQRCPIDPYIMLPDKCECVDYQTLKLQENPEDVPHGEMPRHLQLFTERYLTDKVVPGNRVTIVGVYSIKKLIQKKGGDKSLQGIRTPYLRVLGIHMETSGPGRTNFTTFTPEEERMFKTLAQRKDAYELIAKSIAPSIYGSADIKKSIACLLFGGARKKLPDGITRRGDINVLLLGDPGTAKSQLLKFVEQVSPIGVYTSGKGSSAAGLTASVIRDPQSRSFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVYGRWDESRGDDNIDFMPTILSRFDMIYIVKDTHDVLKDATLAKHVIEVHVNASAAKERDIAGVPKTATTDSDGVMTMFDTDGFLTIEFLKKFVTYARLNCGPRLTPQASEKLVNHYVKMRNPVVNADAFKSGKKAHNSAIPITVRQLEAIVRIAESIAKMELQQFATDKHVEEALRLFRVSTIEAAATGNLAGVEGFTSTADQEALNRIEVQMKKRFAIGTHVSEHLIVQDFVARQHYRESLVKKVIDNLVRRGDLQQKMQRKMLYRVR
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor mcm-5.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: SYI_COXBR
Sequence: MTDYKDTLNLPQTDFPMRANLPEREPQTLARWQTLDLYRKIRKDREGQPKFILHDGPPYANGRAHLGTAFNKTLKDIVVKSKTLSGFDAPFVPGWDCHGLPIELNVEKKLGKDKLSANAFRQACRDYAFSQIELQRDDFQRLGVLGDWQHPYLTMDFGYEADTVRALAKIVANGHLLRGQKPVHWCAACGSALAEAEVEYRDKASPAVDVGFEAVDAEAVRQRFGVKNATTRVLVPIWTTTPWTLPANEAVSVHPELHYALVKSELQNQPVYLILAKDLVDSAMLRYGVDDYEVHGNLKGDALEGMQLQHPFLDRIVPIILGEHVTTEAGTGNVHTAPAHGLEDYFVAEKYNLPINNPVDARGRFIPDTFLVGGQPVFKANEPIIVLLADSGHLLHSETIQHSYPHCWRHKTPLIFRATPQWFIGMNKNGLRERALAEIEKVTWLPAWGEARIGKLVADRPDWCISRQRLWGIPIPLFIHKKSGELHPKSPALMEKVAQLIEKESVDAWFDLDPKVLLGDDADHYEKVTDVLDVWFDSGVTHFCVLEKRRELKVPADIYLEGSDQHRGWFQSSLLTSLAIRDKAPYKSVLTYGFVVDSQGRKMSKSLGNVILPADVVKNLGADVLRLWAASMDYTVEVNVSDEILKRASDAYRRIRNTARFLLSNLYDFDPKKDKVAVDQLVALDRWAIFTTQKLQEKIITAYDRYRFPAIYQAIHNFCTVEMGSFYLDIIKDRLYTSKESGLPRRSAQTALYYIAEAFVRWIAPIISFTADEIWQFMPGDREPSVFLTQWFSDFPNAALSGEEEQRWQLLLQIRDEVNKALETYRNEGKIGSALTAEVVLYADERLNAVIATLGEELRFVLITSEASVLPFNEKSKAAFDTALPGLALEINVSEFEKCARCWQRRSSVGQIKEHADLCDRCVSNAFEDGEMRQFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIRD_SALTY
Sequence: MSQWQNICKIDDILPGTGVCALSGGEQVAIFRPYHSDQVFAISNIDPFFEASVLSRGLIAEHQGELWVASPLKKQRFRLSDGLCMEDEQFSVKHYDARVKDGVVQLRG
What is the function of this protein?
Required for activity of the reductase.
What are the official names of this protein?
Nitrite reductase (NADH) small subunit.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_RHOCS
Sequence: MRAMPLSIGTIHFVGIGGIGMSGIAEVLHNLGYSVQGSDIADNYNVARLRTLGIRVEIGHRAENLGEAAVVVISSAVRTDNPEVVAARAALVPVVRRAEMLAELMRLKWSVAVAGTHGKTTTTSMVAALLDGAGFDPTIINGGIINALGTNARLGSGDWMVVEADESDGTFTKLPATIAVVTNMDPEHLDFYGTFEKEREAFDRFVENIPFYGFAALCTDHPEVQALVARADRRIVTYGFNPQADVRAVNVEGDHRGAFYDVQVSERVTGEARTIERVHLPMYGLHNVQNSLAAIAVAINMGIADEQIRASFARFSGVKRRFTRTGESNGVVVIDDYGHHPVEIQAVLKAARMAGSGRTIAVVQPHRYSRLSSLFEEFCTCFNDADAVIVADVYAAGEQPVEGASKEALVEGLRTHGHRNVQALPSPEALAGIVRELAQPGDMVVCLGAGSITGWANRLPAELDALHGISGGTAPAAKAGGT
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y080_MYCPN
Sequence: MRNLIKNVFRSFRTAKIALIALTFLIFVAVGSFVLLNNTVNNFNASFQHVTEQGQLSNAIINERYDFGKLEFQKTSNDATSSAQPSVSTRSTLTAQKANGANSSFTLTLTPDSRTSFINNALQLKPDVYNSLVTVTFSYGSESDQTKKTQIEEQSKLIAANNLSRALQTDKELLVTGQLEQLKATFRTYKAINITDQGVFKKLIASEPTDQVNRLVLFDGHQLARSRQVEFNELFSQFTQVQAKGKDQLSTTLKNGNYEQLLQAIANNFGSSETELLKEIQDALKQTNSSTTLAQTQSSQQFSKLKNLFDSGSTFTNIAGKLTLQWMEGTNKKQLVIFDPSSYETVVAPGNWSYEQQQGKAVYQDINHWNRIKRLPFNEFEREFQKIDKRYKMLVDKIEYLILGVGITPDFVYPVFSESLLIPNTANEQLYYVNQTGYERTASSFLTNPTETGIVARLPNLNHDLDVINQWAVKNMSWPPNLKAAYSNTDTTNILNLLAARTVFIPNLINTISLVSSFLTIAILLVAIFVTILILVSYLKKNTEQIGILKANGVSGRKINLSLLIFSLIPGIVGSFIGYTLGISMQNVAINLFSNYWFIPTQTSSFSVLGLLFFALLVVLMMSGISLFVGWLILRQDVVKILKHDSEFKVSHLGLWAKWLFAKFGIMTRFRVALAFNAPWKLVFLTLMSALTMMILNLSFATKDAFQVAQTKTTLTQSNHQYEFELASPTEQSGLLKWQLFAELGATDDRTTDAVKLANRRMEIQSVDESKKWKNQQVINFVTDATGFSNDINYLENIVQSKIGLDYSLGFGNVSSNPWKLSETLMPANQASASNTAFQNFLKAIIVIDPNEGGKYIKQTKDEVTVRFLYEIDSSKALKNGNTKSVNKIQKSTAAPQAQQGQSNQLMLDNDFAKFLYKQFNLIKEGGKADPVDLNNFDFANQNQIKRFYSKYNALPPVDYKLAFNVIGLPKETIANQKDAPLFGFLTLQAQLGNDAIKIKGIKDWKLDNTNLGPVLRTNEDEIINQRLFSKPNGIIINSSAAKKYRLKEGSQLHVKIHNGYKRVNAKLVNQDPTLTATFNIVGINNSVHEPEFYTSYKTAATLLQYPNEWIEKQLPFNSFYANSILPFTQSTSLFSESGLFPGTSSFAANNTVLTEVIKKTIEGGKTNSKTDVQKRAAQATANGKYNSSQNNKMNYERLQKALGITSDLDSSKAGEYATILERVYDGLPYNSTISFISNVQANDALFANIANTTQQIQTAAIGIIIPIIMLIVLLVSTTLIQELKKIAIRLKALGYSNPKILLSFLSIYLPLFIFGLLISIPISIYLIALHNQVIFSSAAILLEATLNFPTVILSMLVLSGVLSITFVLNWLELNKIKIAKEIKNS
What are the official names of this protein?
Uncharacterized ABC transporter permease MG064 homolog.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZN830_HUMAN
Sequence: MASSASARTPAGKRVINQEELRRLMKEKQRLSTSRKRIESPFAKYNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVAELKGAKEASQGSSASSAPHSVKRKAPDADDQDVKRAKATLVPQVQPSTSAWTTNFDKIGKEFIRATPSKPSGLSLLPDYEDEEEEEEEEEGDGERKRGDASKPLSDAQGKEHSVSSSREVTSSVLPNDFFSTNPPKAPIIPHSGSIEKAEIHEKVVERRENTAEALPEGFFDDPEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLDRQIGEIDEQIECYRRVEKLRNRQDEIKNKLKEILTIKELQKKEEENADSDDEGELQDLLSQDWRVKGALL
What is the function of this protein?
May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396).  Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity.  During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation.  Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells.  During the embryo preimplantation, controls different aspects of M phase.  During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).
What are the official names of this protein?
Zinc finger protein 830, Coiled-coil domain-containing protein 16.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Nucleus speckle. Note=Excluded from nucleolus.
Protein: MOB1A_PONAB
Sequence: MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
What is the function of this protein?
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Stimulates the kinase activity of STK38 and STK38L.  Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).
What are the official names of this protein?
MOB kinase activator 1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: GSA_AZOVD
Sequence: MSRSETLFANAQKHIPGGVNSPVRAFRGVGGTPLFFKHAEGAYVIDEDDKRYVDYVGSWGPMILGHAHPDVLEAVRRQLEHGLSYGAPTALETEMAELVCSLVPSMDMVRMVSSGTEATMSAIRLARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTLGVPSSPGVPAAFAKHTLTLPYNDLGAVEKTLAEVGREIACIIVEPVAGNMNCVPPAPGFLEGLRAQCDQHGVVLIFDEVMTGFRVALGGAQAHYGVTPDLSTFGKIVGGGMPVGCFGGKRAIMECIAPLGPVYQAGTLSGNPLAMAAGLTTLKLIGRPGFHRELAEYTGRLLQGLQERADAAGIPFVTTQAGGMFGLYFSGADEIVTFADVMASDAERFKRFFHLMLDGGVYLAPSAFEAGFTSIVHGETELSITLEAAERAFATLAKA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.