Protein: EUPA_PHOSX
Sequence: MQTEEWKMANQDNNKPQRDSERCVFLFGSLSLSFDASAFAQVRKAIANDERNSWLVNAARQLPQDLETILSGLPSLNNSNTRARKQLADLHNAIIGGRPLDTPFPLPNTVLIPLVVIEQLSQYADFARQKGVERSGTPDGWPAIEADTKSLGLCTGNLAAFATSSARSWGDFQKYGAAAVRLGLLVGLVIDSQDEAFDSRRWRSLSVAWSGSQGGEELQRILPEFDETYVSVYYDACRSTITTPVSSLPTLVHRLKAAGLGVTEITLYGAFHSAARNSAVLEQLTVFCDSHADFQLSTSAASVAALQANDNTDHKDIIRKQGALHAKALRRILVEPAQWFDALAAVLGEEGERARVVSFGSERSVPLSLAMRSNVRVVHATDTHDGNRGTNADGGERMWAESDIAVIGMACKVAGAEGVEEFWELLVEGHSQHRDISASERFSFDDTAFRTASDSNMQRKWYANLVDGHDQFDHRFFKKSARESAAMDPQQRQLLQVAYQAAEQAGCFTRTNSVCDGNVGCFVGVCLSDYESNVGCHPANAFTATGNLQGFIAGKVSHFLGWTGPALTIDTACSSSLVAVHQACASILAGECNSALAGGTHIMTTAGWFQNLAAGAFVSPTGQCKPFDAAADGYCRGEGVGAVVLKKLSQAIADGDRVLGVIGATAVQQNQNCTPIFVPNVPSLSALFTTVTAKAHVKPASVSVVEAHGTGTAVGDPAEWASIRQTLGGLNRPPERPLMVSSTKGLVGHLECTSGIISLIKVLLMVQKRMLPPQASFDTLNPVLNAQPSDHMFVPRRAQPWDAEFRVALINNYGASGSNASMIVMQPPTFDTVAPIHLAAAVRSPDCRYPFWLSGLDSSSLRRRAKALRRFLSRGLGPASSLAPSLASISYNLAHQGDRALDQRITFTAASVTELDQHLAACEDGSDNKPAAPASTAASKQTVVMCFGGQVSTHIGLDPHVYNSVGLLRQHLDNVDTIIQSLGYTTIFPAIFQRVPLADTVHLQTMLFAMQFACAQAWIDSGLRPTVLVGHSFGELTALCVSGALSLVDAVKMIARRAAIVRDAWGIDRGTMMAVEGDLYEVEQLLVDVNSSISPAVPISIACYNGPRSFTLAGSTDTINEVDARLCAQPGRSIKSRRLNVTNAFHSALVDPLLHRLEESCEDLTFRRPVLYLERALDSTSSGPEWSARSVAEHMRNPVYFHHALQRIVQIDPSSSFVFVEAGTNSSITAMTSRALDNKIIKGTSTFHGLSIANCDDGWNKLTDSIMSLWKAGLNVQHWAHHQRQRRYQADIEPLLLPPYQFDPNARHWMDLKPLPRQLPALIEEATKTEADKKPEGLLTFVGFQDSSTQMQAQFQINTNTEEYKSLLLGHMTIQTAPICPATMQISFVIEAIVTIRHELQTEQEPQIQDVQYRSPVCANLSRKTWIEIKDENERGLAWRFEVFSTESHSGPRTIHTTGKIKFTNARDATLQRQLMQFERLFGHHRATDLLKSAEVDEVLANRSIYLIFSEIVDYGEEYRGLQKFASKGHESAGHVVRRHSHDRKTPRFDAHLADTFCQLGGIWINCMTERSQDDIYLANSIDQWIRSPHNAGAAGSTVEPSKEYHVYATHHRPSDKLSLTDVFVFDVKAGKLVEVILGIAYVKIPKLSMQKMLTRLTGSEWLNNTPATSMNQAPVSAPNPATRPSIVDLPSAVTQVPVLLPQGVKPSAEIRPSEPPSRSLLENITERVKAVVADLSGVEVTEIGDECDLADLGIDSLAGMQMVHEIEGALHVTLPEKEILLVVTMRDLMKVVTGVVEVDFEATDSLSSDNDLPSIATSSEGERVATNLTTPAPQSDVDKDEHEAFESNDLRLPAAVVLEAFKETRELTDEHVLGVGQASYVSEALPLQTELSISLTLEAFEALGAGLRNAGPGEQLFRIVHDEEHARFVDYMYDMLEIETQIIKVDRGIITRTAVPFPERSSTVVYAELRRRFPDQRAADELTYYAGTHLMQVLSGETTGVKLIFGTTEGRELVSTFYGEWPLNQVMYTQMEDFFTRLASKLPATNDNKPLRILEMGAGTGGTTKRLVPLLARLQIPVEYTFTDLAPSFVRAARNKWEKLYPWMRFRVHDIEKAPGEDLVNTQHFVLASNAIHATRSIRESTLNVRKFLRSDGYLLMGEMTRTPYWVDIIFGLFEGWWLFDDGRRHALTHESRWETDLQSAGYGHVYWTEGTRPESEIEKLILAAASLTNLAGSDFVQSERNPITKRHQFDNEVSGGCAEREKLIMEYVCDSTQDFAKTFKVPMSSIPRSLHHKSKGKWIVVTGATGGLGAHLVAKAAVRSDVERVVCLNRRSKQNALERQMHALRKQGISLDSECLAKLDVHVTELAQPSSLGLPNELYNLLLDNVTHIVHNAWLMNSKWTVKRFEPQIRIMKHMIHFARDISLRHTESDPVTFIFVSSIATVGFHPLLAKSPIVPEDRVSIDSVLPTGYGEAKYICERMLDTSLHRYPSRFRAAAVRLGQIAGSSLNGYWNPMEHVSFLIKSSQTLRALPNLPGSLGWTPADAIADSLLDICTQPGDVALHPLYHIDNPVRQNWDEMLAVLADVLNISQGASGIVPFDEWLRRVRDWPHTEDNASDGKNPAYVLVDFLEDHFVRMSCGGLLLGTRKAREHSETLACVGPVDAQAIKLYVRSWKDMGFLD
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of eupenifeldin, a bistropolone meroterpenoid that acts as an antitumor agent (PubMed:30980906).  The first step of eupenifeldin biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase eupA (PubMed:30980906).  Oxidative dearomatization of 3-methylorcinaldehyde likely catalyzed by the FAD-dependent monooxygenase eupB is followed by oxidative ring expansion by the 2-oxoglutarate-dependent dioxygenase eupC to provide the first tropolone metabolite, tropolone stipitaldehyde (Probable).  In parallel, generation of sesquiterpene alpha-humulene from farnesylpyrophosphate (FPP) is catalyzed by the terpene cyclase eupE (PubMed:30980906).  The cytochrome P450 monooxygenase eupD then hydroxylates humulene to humulenol (PubMed:30980906).  The putative Diels-Alderase eupF probably catalyzes the formation of the tropolone-humulene skeleton by linking humulenol and the polyketide moiety (Probable).  The short-chain dehydrogenase/reductase eupG and the flavin-dependent monooxygenase eupH are also essential for eupenifeldin biosynthesis and are likely the additional decorating enzymes of the tropolone-humulene skeleton to produce final eupenifeldin or derivatives (Probable).
What are the official names of this protein?
3-methylorcinaldehyde synthase, MOS, Eupenifeldin biosynthesis cluster protein A, Non-reducing polyketide synthase eupA, NR-PKS eupA.