PharMolix/UniProtQA huggingface dataset:
Protein: ORC4_RAT
Sequence: MSNRKSKNNIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the ORC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPS33_YEAST
Sequence: MNRFWNTKKFSLTNADGLCATLNEISQNDEVLVVQPSVLPVLNSLLTFQDLTQSTPVRKITLLDDQLSDDLPSALGSVPQMDLIFLIDVRTSLRLPPQLLDAAQKHNLSSLHIIYCRWKPSFQNTLEDTEQWQKDGFDLNSKKTHFPNVIESQLKELSNEYTLYPWDLLPFPQIDENVLLTHSLYNMENVNMYYPNLRSLQSATESILVDDMVNSLQSLIFETNSIITNVVSIGNLSKRCSHLLKKRIDEHQTENDLFIKGTLYGERTNCGLEMDLIILERNTDPITPLLTQLTYAGILDDLYEFNSGIKIKEKDMNFNYKEDKIWNDLKFLNFGSIGPQLNKLAKELQTQYDTRHKAESVHEIKEFVDSLGSLQQRQAFLKNHTTLSSDVLKVVETEEYGSFNKILELELEILMGNTLNNDIEDIILELQYQYEVDQKKILRLICLLSLCKNSLREKDYEYLRTFMIDSWGIEKCFQLESLAELGFFTSKTGKTDLHITTSKSTRLQKEYRYISQWFNTVPIEDEHAADKITNENDDFSEATFAYSGVVPLTMRLVQMLYDRSILFHNYSSQQPFILSREPRVSQTEDLIEQLYGDSHAIEESIWVPGTITKKINASIKSNNRRSIDGSNGTFHAAEDIALVVFLGGVTMGEIAIMKHLQKILGKKGINKRFIIIADGLINGTRIMNSIS
What is the function of this protein?
Essential for vacuolar biogenesis, maturation and function.  Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole.  Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion.  HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly.  It remains bound to SNARE complexes after vacuole fusion.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 33, Protein SLP1, Vacuolar morphogenesis protein 5.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: SYT_BURP1
Sequence: MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIVTDKDADGLDIIRHSTAHLLAYAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAIEKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEIIESIPASDEIKLYSHGSFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEKRDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFNKLAMSVYEDFGFDRIDIKLSLRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCGTLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAHAVVLNIAESQAEYARTVAQSLQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKEREAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TB182_HUMAN
Sequence: MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV
What are the official names of this protein?
182 kDa tankyrase-1-binding protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.
Protein: THIO2_SHIFL
Sequence: MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQERSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL
What is the function of this protein?
Efficient electron donor for the essential enzyme ribonucleotide reductase.  Is also able to reduce the interchain disulfide bridges of insulin (By similarity).
What are the official names of this protein?
Thioredoxin 2, Trx-2, Protein-disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECR_AEDAE
Sequence: MYRLNIVSTNPSGSVQQQQQAQGQQVISSVVRPQQQQPPPQLALVQTGGSGGTTTTIIGLTSLNALNATTITGLVAGAAGSSTSAIAAAGASNSGSGPSTATTKHILKAATTNNNISIVKIVDDIMLKAVKVEPLPMDTGGGGGGVSMIPSSATTSGGVTVTAIPASVAPMPPVAAGTNVSSNGSVTVYASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQSTTYTTTMSNGYSSPMSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPTPRQQEELCLVCGDRESGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAIKRKEKKAQKEKDKVQTNATVSTTNSTYRSEILPILMKCDPPPHQAIPLLPEKLLQENRLRNIPLLTANQMAVIYKLIWYQDGYEQPSEEDLKRIMIGSPNEEEDQHDVHFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDAATDSILFANNRSYTRDSYRMAGMADTIEDLLHFCRQMFSLTVDNVEYALLTAIVIFSDRPGLEQAELVEHIQSYYIDTLRIYILNRHAGDPKCSVIFAKLLSILTELRTLGNQNSEMCFSLKLKNRKLPRFLEEIWDVQDIPPSMQAQMHSHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGPHPHPHGQQLTPNQQQHQQQHSQLQQVHANGSGSGGGSNNNSSSGGVVPGLGMLDQV
What is the function of this protein?
Receptor for ecdysone.  Binds to ecdysone response elements (ECRES).
What are the official names of this protein?
Ecdysone receptor, 20-hydroxy-ecdysone receptor, 20E receptor, EcRH, AaEcR, Ecdysteroid receptor, Nuclear receptor subfamily 1 group H member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: OVCA2_BOVIN
Sequence: MAAQPLLRILCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVVDAAGSEGARPDSGPCPPEEQPQGWWFSEQEADVFLALEEPTACRGLEEALETVAQALNKLGPFDGILGFSQGAALAALVCALGQGGDPRFPLPRFVILVSGFCPRGLGLMEPIMQGPLSLPSLHVFGDTDGVIPSQESMQLCSRFDGAVTLTHSGGHFIPAAAPQRQAYLKFLDQFAD
What are the official names of this protein?
Esterase OVCA2, Ovarian cancer-associated gene 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the LovG family.
Protein: RL24_MARN8
Sequence: MKKIKRDDEVIVTTGKDKDKRGKVLKVLDDGRVLVSGINMMKKHTKPNPMLGTPGGIVEKEAPIQASNVAIFNPQTGKADRVGFQIKEDGTKVRIFKSTNEAVDNQ
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: KTHY_ALIFM
Sequence: MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVGNVIKPALAKGEWVVGDRHDLSSQAYQGGGRGFDRDLMMTMRNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMKLDFFERSRERYLEFANSDESIITIDAGQDLETVTQSIITALEAWLVNNGY
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ARGB_WOLSU
Sequence: MQKRSKIVSILLDSLPHIKLFSGSTMVIKYGGAAQINPTLKEQFAIDIVLLYMLGIKPVIVHGGGKKITDLLGKLGIESKFVEGHRITCIDSMKIVEMVLSGDINKEITSFLNHHGVKAVGISGKDSSLLRAEPKDGGRFGYTGEVKEVKAEIIYNLLEKGFVPVIAPVAEGEEAGHPGYNINADTAASEIAKAIKARKVIFLTDTQGVLDGEGSLMESLTLSEVEENKRSGVINGGMIPKVDACVECVKGGVEKAHIIDGRVEHSLLLELFTSEGIGTEILRD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDIB_ECOL5
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPAAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: VE7_HPV6A
Sequence: MHGRHVTLKDIVLDLQPPDPVGLHCYEQLVDSSEDEVDEVDGQDSQPLKQHFQIVTCCCGCDSNVRLVVQCTETDIREVQQLLLGTLDIVCPICAPKT
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: DFB12_BOVIN
Sequence: GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW
What is the function of this protein?
Has bactericidal activity.  Active against E. coli ML35 and S. aureus 502A.
What are the official names of this protein?
Beta-defensin 12, BNBD-12, BNDB-12.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CZCB_CUPMC
Sequence: MAISNKQKAAIAAIVLVGGVATGGVLLSGRSAPEEQGGHSESKGHGDTEHHGKQAAEADHKDDKSHGDGEHHEVKKGPNGGALFSRDGYDVEIGTAESKGEARIRLWVSKSGKAVANGVAATGQLVRATGESQALKFVVSGDALESQQPVAEPHVFDVTANVTLPGSSSPLAVRLSKEEGKIELTADQLAKTGVVVQTAGSAKVQAGVQFPGEIRFNEDKTAHVVPRLAGVVESVPANIGQQVKKGQVLAVIASTGLSDQRSELLAAQKRLDLARVTYDREKKLWEQKISAEQDYLSARNALQEAQISVQNAQQKLTAIGASNSSTALNRYELRAPFDGMIVEKHISLGEAVADNANVFTLSDLSSVWAEFVVSAKDVERVRIGEKASINSASSDVKADGTVSYVGSLLGEQTRTAKARVTLTNPQMAWRPGLFVTVDVFGADVEVPVAVKTEAVQDVNGESVVFVAVQGGFVPQPVKVGRTNGKVIEIVEGLKPGARYAAANSFVLKAELGKSSAEHGH
What is the function of this protein?
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC).  The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
What are the official names of this protein?
Cobalt-zinc-cadmium resistance protein CzcB, Cation efflux system protein CzcB.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=May be anchored in the inner membrane, cross the periplasm and contact the outer membrane as proposed for membrane fusion proteins.
Protein: THO5B_XENLA
Sequence: MSSDSLKKRKPKVNRSEDGKRGRHDEQEGRYYSEEAEVDVRDSREDYQLYKDTCVALQRLMSEIQDLKSKGSKDSAMEIEEKKIQSCVHFMTLKKLNRLANIRLKKARDQTHEAKQKVDAYNLQLQNLLYEVMHLQKEITKCLEFKSKHEEIELVSVEEFYSDAPAAISKPEITSTDPHQQTLSRLDWELEQRKRLAEKYKECLASKEKILKEIEIKKEYLNTLQPQLNSIMQASLPVQEYLSMPFDCMHKQYETARHLPAPLYVLFVQASAYSQACDQKLVVAIEGNVEEARALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLCVTLTLMCKEGSTLTLTFYFLMNLNILTVKVKIQPAFELSTAISAGDLLNPDLILGCLYQGDDGKTTPNPANKYQFDKIGILSLSDYISELGHPYVWAQTMGGLHFPTDQPQPEFVADNALSASHMEKTIKLLKTRLLSRLSLHRQFASLEHGSIPVSLECQSLFPAKVISRLTKWNVIAYEDYLALPYTKDVVECGLAKETDQYFCLLIERGTAKLNGVVVLNPDYSSVPPVFSLCLNWKGERSSSNDDNIGVMESEVNVYYKELCGPPPGFQLLTNQIQRLCMLLDVYLETERHDNSVEGPHEFPPEKICLRLLRGPSRTKPFKYNYPQGFFSHR
What is the function of this protein?
May be involved in cell differentiation.
What are the official names of this protein?
THO complex subunit 5 homolog B.
What is the protein family that this protein belongs to?
Belongs to the THOC5 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
Protein: RSMH_VIBVU
Sequence: MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFSGMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHARRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRLSVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_LACLA
Sequence: MKDLISIIDVKDHVGETVKIGAWVADKSGKGKLQFLQLRDGTAFFQAVVFKPNMIENFGEEEGTAKFDEIKHLSQETSVYVTGVVKEDSRSKFGYELDVTDLEVIGQSHDYPITPKEHGVEFLLDNRHLWLRSKRQMAMMQVRNAIIYASYDFFAKNGFIKFDSPILSGNAAENTTELFETDYFGNSAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYPFVTHDESLDIQEAYVKALIQGVLDNAAYALETLERDTSMLQKYIDTPFKRVSYDAAIDLLQAHENDEDTDYEHVEHGDDFGSPHETWISNYYGVPTFIVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSERETDYDLLLKKIADFGLDPKDYDWYLELRKFGSVPHAGFGLGLERMVTFVAGTEHIREAIPFPRMINRIQP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_SINFN
Sequence: MDVKTYPVLEAAKNRTLVDNATYLKWYEESVADPEKFWGEHGKRIEWFEPYTTVKNTSFDGNVSIKWFEDGLTNVSYNCIDRHLKTHGEKTAIIWEGDNPYIDKRITYNELYDKVCRLANVLKKHGVEKGDRVTIYMPMVPEAAYAMLACARIGAIHSVVFGGFSPEALAGRIVDCESTFVITCDEGLRGGKPVPLKENTEKAIDIAARQHVMVNKVLVVRRTGGKVPWAPGRDVWYHQEIATVEPHCPPEKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGDIYWCTADVGWVTGHSYIVYGPLANAATTLMFEGVPNFPDAGRFWEVIDKHKVNIFYTAPTAIRSLMGAGDDFVNRSSRSSLRLLGTVGEPINPEAWEWYYHVVGAERSPIVDTWWQTETGGILITPLPGATDLKPGSATRPFFGVKPQIVDNEGNVIDGPADGNLCITDSWPGQMRTVYGDHERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHHLVSEAAVVGYPHPIKGQGIYCYVSLMAGEVGSDELRQELVKHVRSEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPAVVDDLIANRQNRG
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: GLOP_GLAL2
Sequence: MLSEVIARVELLIGEQTLSGGILTFLFIVVIAHFVLTRFTVHSRFWNSQAWTGVREEWFPKMRAKVRTIGNIRQMLSDGYEGFSKQNKAFALPVIAEKPWLVLPHSCIPELLAKSDSEIDMKIIHEEQLMHEYTTGSLGRHVVDVPIQYDILLRQVNRKLPLLISAFNEELDKSFCHYWGTDTSYSEVNLSETCEKIVTQALNRIFAGKEICRDEGFLEHSRLYSEGVGRNAIMVRMLPPLLRPLLAPFITYSNRKHRDICLRVCLPVIRERVQHTAAKRADAEHKWEPPLDVLQWIIEESFARNDPKELDPRMITQRLLALNFVAIDTTHMSMAHTILDLYRSPNSDDFLVGLREECERVLQANGGQWTKSGLDDLVCVDSTIRESMRYSDLGYISLTRMVVDPKGTQFNANGTNSSSPLSVPPGIRICVPAHAIHRDAALYPSPYEFQAFRFSKAREKYRGTQTELSEPKVSIVTTTDKFLPFGHGRHACPGRFFAAQQMKLMLAYLVQNYDVEKLSTKIQNKIMVGTTKPDASLKIKVKRRKV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase (PubMed:27705900).  The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4 (PubMed:27494047).  The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain (PubMed:27494047).  The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide (PubMed:27494047).  L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain (PubMed:25270390, PubMed:25879325, PubMed:25527531).  The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0).  Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively (PubMed:25879325).
What are the official names of this protein?
Cytochrome P450 monooxygenase gloP, Homotyrosine 4-hydroxylase, Pneumocandin biosynthesis cluster protein P.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SLA1_YARLI
Sequence: MPSLFHGVYQALYDYEARTEDELTFSENSLLYLLEKSSTDEWLKAKKAGPAGTNEIGLVPLTYIEPAPAKRQAYALYDYDKQTEEELTFKEGDALTVYDDSDSEWLLVCRGGDEYGFVPANYTGDAPPSAAPAPVAAIPTPVAAIPTPAGQPTTPITKDSPLPPLPKDAFPPPPQAYRPPASTTHASTEPVYANGRDEESPPPMPARPGGSGNGSGRPSSGAGDSRSRGSSVSRSRNASSANDKPSSSSANFFTWPVQEVDGRKKRKATLAIGNGMIMFSPERSSGQPQQWPVKDLVNYNSEKKHVFLDFKHPTVSFDLHLGSKDTADEVIYALGELAGAYNSSGLTEVMMAANSAGQKLGKVLYKFDAQGRDEVSVEEGENVFIIDDTKSRDWWMVKNSSGVAGVVPSSYIEIAPSEKTLKKVVDQQRKASGSSRDKSRDRSRDDRSRDRADKRSSRSSRDAPKSKPDPRKVRTWTDRSGAFKVDAALLGCVDGKIHLHKVNGVKIAVACSKMAIEDLEYVEDVTGVDLEEDKPLSRDRGGSSRDRRRSTSRSDRRKSSSGAASSANAPKPTPESDYDWFGFFLDCGVDVHACQRYATSFTRDQMDESILPEVTPSTLRSLGLKEGDILRVTKKLDEKYGRSGTGTSASTPVGGNPSGGLFSDTTGALKNNTSKTLTKADDTDPWSSLDKQQAPPQQQAPPVQQQPPVQQQPIQAQPTAPIQQQPIQAQPTAPIQPVRTGSINDLMNIKPLQPTPTSSNLQTQATGGIMQPIQQQYTQQPMSQSTSALPQQSMNTGILPQTTGPLQQSLTGSAPVQNPFLTGGPNTLLSQQTGGLVGVPTGGLVGVPTGGLQGVPTGYTAQNVLGMNQPANTGGYSMNAITNALAGASLNKQQQQQQPMVQQLTGGSMFGQQPMQQQLTGSSIFQQQPMQQQFTQQQPMQQQFTQQQPMSQQLTGGSIFNSQPQQPFQQQPMQPQQTSFQQQQPFSTGASASPFGSQPTTPFGQPQQSAGLSYFNNIQPLQQQQAFGQQMQPQQTFQPQQPFQQPFQQPFQQQQQQPFQQQQQQPFQQQQQPFGGLQSQPTGFGFGNSSSPFGGMQSQQTGAPSTSFGQQPLQPTATGRQRANLASATPNNPFGF
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein SLA1.
What is the protein family that this protein belongs to?
Belongs to the SLA1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: DNLJ_PSESM
Sequence: MKAAETRILELRAELDQHNYRYHVLDEPSIPDAEYDRLFHELKALEAENPHLVTPDSPTQRVGSAALSAFTQVRHEMAMLSLGNAFEENDLREFDRRVTEGLDLPAGDLFGEGGKVQYSCEPKLDGLAVSLLYRDGALVRGATRGDGTTGEDISVNVRTVRNIPLKLQGKGWPELLEVRGEVFMSKAGFERLNASQLEVGGKTFANPRNAAAGSLRQLDSKITANRPLEFCCYGLGQTSAEIADTHIGVLETLKKWGMPVSRELKLADGVEECLAYYRDIGERRLSLTYEIDGVVFKVNNLAAQRELGFRAREPRWAIAHKFPAMEELTELLDVEFQVGRTGAVTPVARLKPVKVAGVMVANATLHNMDEVARLGLMIGDTVIIRRAGDVIPQVVQVVVERRPETAKPVEVPQSCPVCGSHVERTQLIKRSKGKETVTEGAVYRCVGRLACGAQLKQAIIHYVSRRAMDIEGLGDKTIEQLVDEKLIGSPADLYKLKYEQIIDLEGFAEISSNKLLKAIADSRQPTLARFIYALGIPDVGEETAKVLARSLASLDRVKQALPEVLTYLPDVGLEVAYEIHSFFEDEHNRNVIDALLGECGLQLQDQGELGAEFAASTTLEGLIDKLHIPSVGPGAAQKLADRFGTLEAVISADWLDMRQTLPEKQAKSVRDFFDDNANAERARAIEAQLKDFGMHWRSEKKTVEGLPLAGQTWVLTGSLERMSRDVAKEKLESLGAKVSGSVSAKTHTVVAGPGAGSKLTKANELGLTVLDEEALLKRLTELGVAVD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.