PharMolix/UniProtQA huggingface dataset:
Protein: PSIK_PSICY
Sequence: MTFDLKTEEGLLSYLTKHLSLDVAPNGVKRLSGGFVNVTWRVGLNAPYHGHTSIILKHAQPHLSSDIDFKIGVERSAYEYQALKIVSANSSLLGSSDIRVSVPEGLHYDVVNNALIMQDVGTMKTLLDYVTAKPPISAEIASLVGSQIGAFIARLHNLGRENKDKDDFKFFSGNIVGRTTADQLYQTIIPNAAKYGIDDPILPIVVKELVEEVMNSEETLIMADLWSGNILLQFDENSTELTRIWLVDWELCKYGPPSLDMGYFLGDCFLVARFQDQLVGTSMRQAYLKSYARNVKEPINYAKATAGIGAHLVMWTDFMKWGNDEEREEFVKKGVEAFHEANEDNRNGEITSILVKEASRT
What is the function of this protein?
4-hydroxytryptamine kinase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571, PubMed:30283667).  The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD.  PsiD does not decarboxylate phenylalanine, tyrosine, or 5-hydroxy- L -tryptophan (5-HTP) (PubMed:30283667).  4-hydroxy-L-tryptophan is accepted as substrate by psiD as well.  The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine.  The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin.  The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin.  4-hydroxy-6-methyl-l-tryptophancan also be converted the decarboxylase PsiD, kinase PsiK, and methyltransferase PsiM into respectively 6-methyl-norbaeocystin, 6-methylbaeocystin, and 6-methylpsilocybin (By similarity).  PsiK kinase can also turn psilocin into psilocybin (PubMed:35583969).  This activity may represent a protective mechanism to rephosphorylate the unstable psilocin to the stable psilocybin in case of intracellular ester cleavage (PubMed:35583969).  Moreover, psiK is able to O-phosphorylate the quaternary amine 4-hydroxy-N,N,N-trimethyltryptamine (4-OH-TMT) to yield aeruginascin, another bioactive compound found in Psilocybe species (PubMed:35583969).
What are the official names of this protein?
4-hydroxytryptamine kinase, Psilocybin biosynthesis kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: RR3_PHAAN
Sequence: MGQKINPLGFRLGTTQSHDSIWFAQPTKYSENIQEDKKIRDWIKNYIQKNRRISSGVEGIGEIKIQKRIDLIQVIIYMGFPKLLIEGKPQKIEELQTNMHKKLNCVNRKLNIAIVKVTNAYKHPNILAEFIAGQLKNRVSFRKAMKKAIELTEQAGTKGVQVQIAGRIDGKEIARVEWIREGRVPLQTIRAKIEYCCYTVRTIYGVLGIKVWIFSK
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KYNB_BACCZ
Sequence: MKTSEWIDISQPLNNDIATWPGDTPFSYEVSWSKEESGSVNVGKLTMSIHTGTHIDAPFHFDNEGKKVIDLDVQVYVGPARIIDVSNLESIGKKELENFHLEGVERLLLRTSSHGKANEFPDVIPHLRADIAPFLSEKGIRLIGVDVPSVDPLDDKELAAHHQLFKHGIHILENVVLDHVADGDYELIALPLALSDADGSPVRAVIRPI
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: FGD3_MOUSE
Sequence: MELGRSSSTPQEEAISPLGVLGTGPSSSPLGKLQALPIGPGAHRGAHSSSAPAGDSSTREPSGAMKIPNRDSGIDSPSSSVASENFPCEESSEGSPSPAILGLPSETASDSRVPQDNPQEEEDSGVGEEPDPKVTLFRPQEDVSLTQCSDPQKLLHIAQELLHTEEAYVKRLHLLDQVFCTKLTEAGIPLEVTTGIFSNISSIYRFHGQFLLPELQKRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPRDAPDRKDAERSLELISTAADHSNAAIRKMEKMHKLLEVYEQLGGEEDIVNPANELIKEGSIQKLSAKNGTTQDRHLFLFNNVMLYCVPKLRLMGQKLSVREKMDISDLQVQDIVKPNAACTFIITGRKRSLELQTRTEEEKKEWIQVIQATVEKHKQKSETFRAFGGACSQDEEPTLSPDQPVMSTSSVEPAGVADSNGGTPGIESRKSSSKTRRDKEKPGCKSCGETFNSITKRRYRCKLCGEVICRKCSEFKAENSKQSRVCRECFLEEPLVPPSPSSETPTELKQNAEKPPSVDPRPSLLCGTLNLSDDGTTWNEVWAAIPESDPQVLDLLAGSQAGRLLYSIPLSGCNITMPDPEEGLEAGCAWKLHQGSQTWWLSAPSTKLQQCWLKALGTAVHGDTAGDRPGASQPQAPAGTDTP
What is the function of this protein?
Promotes the formation of filopodia.  May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.  Plays a role in regulating the actin cytoskeleton and cell shape.
What are the official names of this protein?
FYVE, RhoGEF and PH domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: CB22_POPEU
Sequence: SAPQSIWYGPDRPKNRELEVIHSRFGEAVWFK
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein 2, chloroplastic, LHCII type I CAB-2, LHCP.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GATB_METC4
Sequence: MTERVDPKKLIKGGLHDWEVVIGMEIHAQVTSRSKLFSGASTEFGGEPNDHVSLVDAAMPGMLPVINEECVAQAVRTGLGLKAQINLRSVFDRKNYFYPDLPQGYQISQYKDPIVGEGEVLVDLPEGESITVGIERLHLEQDAGKSLHDQDPTKSFVDLNRSGVALMEIVSRPDLRSSEEARAYVTKLRTILRYLGTCDGDMEKGSLRADVNVSVRRPGEPLGTRCEIKNVNSIRFIGQAIETEARRQIAILEDGGKIDQETRLYDPGKGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAYVDALASGLPELPDAKKARFIKDFGLSAYDAGVLVAERASADYFEAVARGRDGKAAANWVINELFGRLNKEGRSIEDTPVSAEQLGTIVDLIGDGVISGKIAKDLFEIVWSEGGDPRAIVEARGMKQVTDTGAIEAAVDAIIAANPDKVEQAKAKPTLLGWFVGQTMKATGGKANPAAVNALLKDKLGIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: VPB10_MYCTO
Sequence: MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS
What is the function of this protein?
Putative antitoxin component of a possible type II toxin-antitoxin (TA) system.  The cognate toxin is VapC10 (By similarity).
What are the official names of this protein?
Putative antitoxin VapB10.
Protein: DEOD_HISS2
Sequence: MTPHINAPAGAFADVVLMPGDPLRAKYIAETFLENAQEVTNVRNMLGYTGTYKGRKISVMGHGMGIPSCSIYAKELITEYGVKKIIRVGSCGAVNMDVKIRDVIIGLGACTDSKVNRIRFKDNDFAAIADFGMARAAVQAAKNKGIDVKVGNLFSADLFYTPDLEMFDVMEKYGILGVEMEAAGIYGVAAEFKAKALTICTVSDHIRTHEQTSAEERQLTFNEMIEIALESVLLEDSL
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: KMS2_SCHPO
Sequence: MDEYIPFDDIVRQYDPDYTGKVSIQAFLEIVDDVDALRLNPEAPLLDNEQRQSAQDFIKDNSEIVVSTSEIKNLFYELTGLDPDTLPVNKLALRENGVLPRKSVAKPQKISENRIKRKDMFYQDASYITPRKGSPLSHSTPLSMFRTKNEYGSNKGFSHINKENADDSLIQQLYERIELQAAELRSKDEQVKELNARNAKLLEELDSSEEACKSCYTQAKTWEKKFREALRDSKEYAAQLQTIHEEYEQQQAHIVRMEELIHAVEKERKTETDYMKKESLSEQKERGAFMESNMILEEKVAHLQLENEQLRLFFKEKAPQPFQNHPPYQNLKITFPSPFFHIPYIPKTETLNDSQFAAGLSLLASELESQKNLLKKFENLKKKSSKDFLSPSTILSNAFSKVSLPNSLILRVLFFSLLFIIGIHIFYFLFFHVATIQQWPFLFWLPSTKFDNRWSPT
What are the official names of this protein?
Karyogamy meiotic segregation protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Note=Associates with the spindle pole body (SPB).
Protein: PHEC_PSEAE
Sequence: MPKSFRHLVQALACLALLASASLQAQESRLDRILESGVLRVATTGDYKPFSYRTEEGGYAGFDVDMAQRLAESLGAKLVVVPTSWPNLMRDFADDRFDIAMSGISINLERQRQAYFSIPYLRDGKTPITLCSEEARFQTLEQIDQPGVTAIVNPGGTNEKFARANLKKARILVHPDNVTIFQQIVDGKADLMMTDAIEARLQSRLHPELCAVHPQQPFDFAEKAYLLPRDEAFKRYVDQWLHIAEQSGLLRQRMEHWLEYRWPTAHGK
What is the function of this protein?
Forms alternative pathway for phenylalanine biosynthesis.  Can catalyze two reactions: prephenate dehydratase and arogenate dehydratase.  May have a role in chemotaxis or transport.
What are the official names of this protein?
Cyclohexadienyl dehydratase.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PDXK_ECOUT
Sequence: MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKDCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKALTDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
What is the function of this protein?
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i. e.  PNP, PLP and PMP.
What are the official names of this protein?
Pyridoxine/pyridoxal/pyridoxamine kinase, PN/PL/PM kinase, B6-vitamer kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxK subfamily.
Protein: YIDH_ECO57
Sequence: MKISRLGEAPDYRFSLANERTFLAWIRTALGFLAAGVGLDQLAPDFATPVIRELLALLLCLFSGGLAMYGYLRWLRNEKAMRLKEDLPYTNSLLIISLILMVVAVIVMGLVLYAG
What are the official names of this protein?
Inner membrane protein YidH.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2272.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YDEO_BACSU
Sequence: MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDGGVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFFHHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLILFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMVETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDVAEVKGSNFRNLNHH
What are the official names of this protein?
UPF0750 membrane protein YdeO.
What is the protein family that this protein belongs to?
Belongs to the UPF0750 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLUE_XANCP
Sequence: MLVLLNKPYGVLSQFSDRSTPPKRTLAEFGLPPQVYAAGRLDHDSEGLLLLTDDGPLAHRLTDPRHKQPKTYWVQVEGDPDTSQLQALCDGVLLNDGPTRPANVRRLECAPTLWPRDPPVRVRKTVPDAWLEVQITEGRNRQVRRMTASVGLPTLRLVRVAIGAWSLASLQPGQWRVDDARAVRPAR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase E, rRNA pseudouridylate synthase E, rRNA-uridine isomerase E.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: CSPC_ECOL6
Sequence: MAKIKGQVKWFNESKGFGFITPADGSKDVFVHFSAIQGNGFKTLAEGQNVEFEIQDGQKGPAAVNVTAI
What are the official names of this protein?
Cold shock-like protein CspC, CSP-C.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJHX_ECOLU
Sequence: MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRAQLDNR
What are the official names of this protein?
UPF0386 protein YjhX.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: LRC34_RAT
Sequence: MEKLQDQYSFLCSENIRKTNPLILNILQKLDEEIEKRPKEKITVNIAGNSRLDSGQRITSEDFWLLSKALRNHPCIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVLTQNKAIKGINLNRPILYGEQEESTVHIGHMSKQNHVLVELHMCKHGMKNYGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDEDTCVAYSNLIESGRLKPENTDVEPYVVDEHIYLSEVSNGLKRHYYWTPTYGECYVPSSSAGFALVPVGERL
What is the function of this protein?
Highly expressed in stem cells where it may be involved in regulation of pluripotency.  In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4.  Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4.  Promotes stem cell proliferation in vitro.
What are the official names of this protein?
Leucine-rich repeat-containing protein 34.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
Protein: O166_CONAE
Sequence: MKLTCVLIVAVLILTACQLIAADDSRDLKRFSRRKMRDGMLNTKNMKRQCLPPLSLCTMDDDECCDDCXLFLCLVTS
What are the official names of this protein?
Conotoxin ArMKLT2-0251.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IF3_HAMD5
Sequence: MKPGKRVPLARPNRINKEIRVTEVRLTGIEGEQIGIVSIAVALQKAEEAGVDLVEISPNADPPVCRVMDYGKFLYEKSKSIKDQKKKQRVIQVKEVKFRPGTDEGDYQVKLRSLTRFLEEGDKAKITLRFRGREMAHQQIGMAMLERIRRDLCESENSIALVESFPARIEGRQISMVLAPKKKQ
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP1D_CHLT2
Sequence: MKTRSEIENRMQDIEYALLGKALIFEDSTEYILRQLANYEFKCSHHKNIFIVFKYLKDNGLPITVDSAWEELLRRRIKDMDKSYLGLMLHDALSNDKLRSVSHTVFLDDLSVCSAEENLSNFIFRSFNEYNENPLRRSPFLLLERIKGRLDSAIAKTFSIRSARGRSIYDIFSQSEIGVLARIKKRRATFSENQNSFFDAFPTGYKDIDDKGVILAKGNFVIIAARPSIGKTALAIDMAINLAVTQQRRVGFLSLEMSAGQIVERIIANLTGISGEKLQRGDLSKEELFRVEEAGETVRESHFYICSDSQYKLNLIANQIRLLRKEDRVDVIFIDYLQLINSSVGENRQNEIADISRTLRGLASELNIPIVCLSQLSRKVEDRANKVPMLSDLRDSGQIEQDADVILFINRKESSSNCEITVGKNRHGSVFSSVLHFDPKISKFSAIKKVW
What is the function of this protein?
Required for growth within mammalian cells.
What are the official names of this protein?
Probable plasmid replicative DNA helicase, DnaB-like protein, Protein P-3, Virulence plasmid protein pGP1-D.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: FADJ_IDILO
Sequence: MSQDKAFTMEVRDDGVAVITIDVPGESMNTLKDSFAEEVGSLMNRLESDDSVKGVVFISGKPGSFIAGADINMIDGCENAVDAESLARKGQAMFDRIEQLNVPVVAAINGACLGGGLELAMACHVRVCTDNSKTALGLPEVKLGLLPGSGGTQRLPELVGVQQGLTMILTGKELRAKQALKAGLVTEVVPQSILLDVAVEHALKRKPKSTKPPLKGISKVLEATKFGRDIIFKKASEQAQKKAQGNYPAIDKIIQTVREGVERGREAGLDKEARSFGELAMTPESYQLRQIFFATTEMKKETGADGVKPDSVKRVGVLGGGLMGGGIAYVTAAKAGIPARIKDIAEDGIRHALHYSYERLDKKVKRRHMRRAELEKTMLMLSGSLDYSGFERTDVVIEAVFEDLNLKQKMVADVEEHADESTIFATNTSSLPITQIAAKAKRPEQVIGLHYFSPVDKMPLAEIITHPGTSDKTIATTVSLAKKQGKTPIVVKDGAGFYVNRILAPYMNEAARLLLAGEPIEHIDKTLVKFGFPVGPITLLDEVGIDVAAKVAPVLVKELGDRFEAPEAFEKLIDDDRKGKKNQKGFYQYGKSVKGKPVDTSVYSLLDIDPNESKSADEIIDICLLPMLNEAAYCLQEEIIRSPRDGDIGAIFGIGFPPFLGGPFRYMDSQGLETIVNKLEKLAAERGERYTPAPLLKQMLENGWNFYQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICSA_ASPFU
Sequence: MPYAGNLPTPTENKVSQIISIISAYRHRSAAVPDRFSEFAPALEKQLTETVSKGEPVRFILPSFPFKAPAEGDKRKTLGSLPDKAEEIALQTLDAFADSIAEIHQPGATVVIVSDASVYGDLLKIPDADAFAYHQELKKLAASLGLTHLEFVRPGTLAGIVPEEAKTLEEYSDHVSKTRNLLDGTLAQAVDPNEDENMRATSKHYDTALPQAEDHEAFKAAMLKRGKAYAKLIASSAESTIRLSIHESNNVGKITMNLFPPPTSPDFITPWHGAVAVLADASVRIVDASTVDRDRFEVITNHEGRPWLLREKSDLFDWFGMELDFEPLFPCGMQVRPKEGYGPYRFEDVNMKLVRRLALSTAPLLLRGFTMQVEKEVFRSKARELGEIQMWPFGDILEVRENADFNMNNVLTREAMPFHYDGVFKTVQDEKTGEWISVPPLFQMFRNRAASQSKGGLTLFASSRNLIPLLGPDSIPLEELRKLQWETFTAANEAFGGHKLQLPFIITHPESGVDTFRFHEPWPESKCVPGSSEPTLVRVVGWPLAESDALCEKLTRLLYDRRVAYRHQWKAGDFIFNDNAMTHHTRTAFEDGHREHWRVHVN
What is the function of this protein?
Isocyanide synthase involved in the biosynthesis of isocyanides (or isonitriles), a class of microbial secondary metabolites.  The presence of an isonitrile moiety within a compound imparts unique biological (cytotoxic, antibacterial, and antiprotozoal) and chemical (transition metal coordination) properties and enables synthetic and biochemical applications.
What are the official names of this protein?
Isocyanide synthase A, ICS A.
What is the protein family that this protein belongs to?
Belongs to the isocyanide synthase family.
Protein: DPOL_GSHV
Sequence: MHPFYQLFRNIQSLGEEEVQELLGPPEDALPLLAGEGLNHRVADALNLQLPTADLEWIHKTNVITGLYSTQTEKFNCNWKQPVFPKIHLDNNLFQKLENYFGPLTTNEKRRLKLVFPARFFPNATKYFPLLKGIKDKYPNYTIEHFFAAANYLWTLWESGILYLRKNQTTLTFRGKPYSWEHRQLEQHNGQQHKSNIRSQQISCMVANSGNLLYTHYHRDKSSNIQTRNLSDNVFKKSKESTRVRCYTYDKIQRNRLGQLARIPCESKAPSEQQQSSLRSKGRDFRNQIQAYNSSRNKGYTTWHSTTSDSIQSGSKKKTHTSNSSFERHTPSFDNEKSDRSPAGICRGTESSNHLRSSQLCLWRSFYYTKPCGTYCLHHIVSSIDDWGPCTFDGDVTIRSPRTPRRITGGIFLVDKNPYNSSESRLVVDFSQFSRGHSRVHWPKFAVPNLQTLANLLSTNLQWLSLDVSAAFYHIPVSPAAVPHFLVGSPGLERFASCMSHDASNRNNSKLQTMHHICSRHLYNTLLLLFKTYGRKLHLLAHPFIMGFRKLPMGVGLSPFLLAQFTSALTSMVRRNFPHCLAFAYMDDLVLGARSYEHLTAVYSHICSVFLDLGIHLNVEKTKWWGHTLHFMGYTINGAGVLPQDKHVHKVTTYLKSIPINQPLDYKICERLTGILNYVAPFTKCGYAALLPLYQAIASHTAFVFSSLYKNWLLSLYGELWPVARQRGVVCSVFADATPTGWGICTTCQLISGTFGFSLPIATAELIAACLARCWTGARLLGTDNSVVLSGKLTSFPWLLACVANWILRGTSFCYVPSADNPADLPSRGLLPALRPLPLLRFRPVTKRISLWAASPPVSTRRPVRVAWASPVQTCEPWIPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: DEF1_RAPSA
Sequence: MAKFASIIALLFAALVLFAAFEAPTMVEAQKLCERPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC
What is the function of this protein?
Possesses antifungal activity sensitive to inorganic cations.
What are the official names of this protein?
Defensin-like protein 1, Cysteine-rich antifungal protein 1, AFP1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_SALPA
Sequence: MPVITLPDGSQRHYDHPVSPMDVALDIGPGLAKATIAGRVNGELVDASDLIENDATLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVVDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFVKRGESYKVSILDENIAHDDKPGLYHHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHIFCTEEQIRDEVNACIRMVYDMYSTFGFEKIVVKLSTRPDKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVIIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVVMNITDSQSEYVNELTQKLQNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGSLDVNDVIEKLQQEIRSRSLQQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_FRATF
Sequence: MFSFYFNDNKITKLLMVGYGSTGKSVCDFLANFIDITVDISQNDDEFVNYDLNSYDLITVSPGIPLNKSPYRALTKFKDKIVSDIDIFYQYIKDTKAKTIAVTGSNGKSTVVTMTDFVLKDLGYKSILVGNIGTPALNKIGEKFDYCVVEVSSFQINLFNCVRFDLGCIINVSPDHLDRYQNFEQYKQSKLNLAKFSNDFFVYDVHNGIKYAGEYQIIRGAIYRNSTKLLDIVETKLFGEHNLENIIVVLNILDRLGLDINQAIDSIKKFKGLEHRCKIVKKVNGTTYINDSKGTNVGATIAALNSITNSKNIILLLGGVAKGGDFSLMIKSLDKYVKYVYIYGADKEYIESYIKGYCKYQLCNNMKQAFELASQKANSNEIVLLSPACASFDEFSGYAQRGEVFQNLVAQLEQKS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y837_STRP2
Sequence: MRKSFYTWLMTERNPKSNSPKAILADLAFEEAAFPKHTDDFDEVSRFLEEHASFSFNLGDFDSIWQEYLEH
What are the official names of this protein?
UPF0346 protein SPD_0837.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: ATPE_UREU1
Sequence: MANLTKLKIVTPYAQNLEKDVYSVELKTSEGRIAVLPDHNPLMSIIENHVAYIRELPNAPRKPLLLLDGIVYVEEHQVRVFSDYFKFLDEIKIDEINSLLNKLKNDLANEEDDKKKLQLKSKIKLNESILIAYKDR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HUTU_BACSU
Sequence: MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPEDLIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANSVLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGSLKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEALAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYSLDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLENAFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDMAQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPNRETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSELADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.