PharMolix/UniProtQA huggingface dataset:
Protein: MED17_BOVIN
Sequence: MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 17, Cofactor required for Sp1 transcriptional activation subunit 6, CRSP complex subunit 6, Mediator complex subunit 17.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 17 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IRF2_CHICK
Sequence: MPVERMRMRPWLEEQINSNTIPGLKWINKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKYQSGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKTKSEKDDKFKQIKQEPVESSFGINGLNDVTSDYFLSSSIKNEVDSTVNIVVVGQPHLDGSSEEQVIVANPPDVCQVVEVTTESDEQPLSMSQLYPLQISPVSSYAESETTDSVPSDEENAEGRLHWQKKNIEGKQYLSNLGMRNTSHMLPSMATFVANKPDLQVTIKEESCPLPYNSSWPPFPDIPLPQVVSTASTSSSRPDRETRASVIKKTSDITQSRVKSC
What is the function of this protein?
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes.  Also acts as an activator for several genes including H4 and IL7.  Constitutively binds to the ISRE promoter to activate IL7.  Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth.  Antagonizes IRF1 transcriptional activation (By similarity).
What are the official names of this protein?
Interferon regulatory factor 2, IRF-2.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIG_PROM3
Sequence: MSATALQVKTTQKPNSRLALEVAVPAERCQANYEAAVTRLSRTINLPGFRKGKVPRAVLLQQIGLVRIRATALETLVDAVWREVLEQESIEPLCEPELSGGFDALLESFQPGEALTLILETDVTPTPKLKATKGLQAEAEVVTFDPSKVDELIEQSRKQLATLVPVESRPAAIGDIAVVSFSGTYDDDGSAIEGGSSESMDVDLEDGQMIPGFVEGIIGMSLGSEKTVDCHFPDDYSKEDARGRKASFVINLKELKTRELPDLDDAFAQQSSDKATLEELRNDLEQRLQEDAKRRDRSNRHDALLEALTEQLEVDLPNTLVQQEIRNLVEQTASQFAQQGMDVKSMFTPELVRSLMESSRPEAEERLRRSLALTALAESEDLKIEESEISAKVKEVSRELSGERDIDPARLRQAVSDDLLKDKLLDWLEDNSTITEKVLESEAKTSKPAAKSKGSKTKSTKTKTNKAKTEKPASDKTKS
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: VPC34_MYCTU
Sequence: MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVLAG
What is the function of this protein?
Toxic component of a possible type II toxin-antitoxin (TA) system.  A putative RNase.  Its cognate antitoxin is VapB34 (By similarity).
What are the official names of this protein?
Putative ribonuclease VapC34, Putative RNase VapC34, Toxin VapC34.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: MTLD_STACT
Sequence: MKAVHFGAGNIGRGFIGQILSDNNVEVTFSDVNSAIVDALNHDHQYDVILADEARTTSTIKGVDAINSAQDPEKLHQALLEADIITTAVGVNLLPIIAKSLAPALKEKETPVNVVACENAIMATDTLKEAVLDITGPLPDHIHFANSAVDRIVPQQTHENILDVLVEPFFEWVVEADAWYGPQLEHIKYVDDLRPYIERKLMTVNTGHAYIAYAGQYYGHQTVLDAISDGKVESGLREVLNETSQYIIDEFGFSEQEQADYVEKIIGRFKNPNLSDDLTRVGRGTLRKIGPKDRIIKPLNYLYEHDLAHEGLTHEAAFLLKYQDDKDTETVEKNKYIQEHGIEAFLKEYAQIDSKLAAEIESVYNQL
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: CCA_LEGPL
Sequence: MKVYLVGGAVRDRLLGIPVQEQDWVVVGATPEELLKRKYRQVGRDFPVFLHPETKEEYALARTERKSAPGYYGFICDFSESVTLEEDLARRDLTINAMAMDEQGNLIDPYQGQRDLEEKLLRHVSSAFAEDPVRVLRVARFASRFHHLGFRIANETRLLMYSMVKQGELAHLIPERVWQEWQKSLEEKNPEQFILSLRSCDALRVILPEINSLFGVPNPHQYHQEIDTGIHSLMTLRASSELSEEPLVRFAALVHDLGKASTPIQAWPKHHGHEEEGTKLIRALCARLRIPNDYRDLAVTVARAHLNIHRVCELRPNTIVKLLEQVDAFRRPQLFHKILIACQADAESCGKTVVYRQTQLWNEILSECVKVTPQTFIVQGYEGKAIKEAMHQSRVACVERIMTSWKSNEK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: OPLA_HUMAN
Sequence: MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV
What is the function of this protein?
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase, 5-oxo-L-prolinase, 5-OPase, Pyroglutamase.
What is the protein family that this protein belongs to?
Belongs to the oxoprolinase family.
Protein: ISPH_LEIXX
Sequence: MRGLLQDIPVRGQKRVLLAAPRGYCAGVDRAVIAVEKALERYGAPVYVRKQIVHNIHVVSELERQGAIFVDEVDEVPEGAHIVFSAHGVSPAVVAAAADRGLRAIDATCPLVTKVHREAVRFARDDFEILLIGHEGHEEVEGTAGHAPERVTLVNSPDEADTIEVKDPDRVVWLSQTTLSVDETMETVRRLRERFPNLQNPPSDDICYATQNRQVAIKKVAQSADLVIVVGSANSSNSVRLVEVALEYGAKAAYRVDYASEIRQEWLDGVATVGVTSGASVPEVLVQEVLADLAGAGYADVQEVKTAEEDLMFSLPKELRKDIAGKRDERALGGRRS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: YOR31_YEAST
Sequence: MTKLQGLQGLKHIKAVVFDMDGTLCLPQPWMFPAMRNAIGLEDKSIDILHFIDTLPTEKEKKEAHDRIELVEAKAMKEMQPQPGLVDIMRYLTKNGISKNICTRNVGAPVETFVKRFIPSELSRFDYIVTREFRPTKPQPDPLLHIASKLNIRPLEMIMVGDSFDDMKSGRSAGCFTVLLKNHVNGHLLLEHKELVDVSVEDLSEIIELIQNMNKESF
What are the official names of this protein?
Uncharacterized hydrolase YOR131C.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCTQ_VIBCH
Sequence: MSVRHTIRAMYHMEQSWFSRVGQFTDSIEEFLIAFFMGAMTLLTFANVIMRYLFNDNILWALEGTVFMFAWMVLVGASFGVKRHFHIGVDVLINIAPARLRKLYALVAVACCLAFSILLLIGSWNYWHPFITERAWYETDDIPMPDMLQFLADWVNEGERYEKLPRFIPYAALPIGMALLTFRFLQIAWQIITGKLDRMIAGHEAEEDLEALKAELSEAGEAMMPKTQGKEK
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
What are the official names of this protein?
C4-dicarboxylate TRAP transporter small permease protein DctQ.
What is the protein family that this protein belongs to?
Belongs to the TRAP transporter small permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y3629_DICDI
Sequence: MENFKNNELESSPIINKNNSSHSINNEDNNYYSHNLEHNDNNNNDNNNTITNSHINNHDHKHNHEHEHKHKHNHDHNHDHDHNHEEEYGHGNELEHNNDQEHNVGNKNLLTNNNNQSKKKKHGHSHGGGEDGSSSGGGGGRHGHGHSHGGGSGSDHNHGSSDEDDEESKPLNQLRNLDSKKKARYSLILALTLTTIFMVGEIVGGYFANSLAIMTDAAHLLTDIGAMFLSLFAMWISQHPPTSSMSFGFHRAEILGALVSVLMIWALTGVLVYEAIQRILYPPDAVDGKIMFIIASCGLFINIIDAIILHWGSGGHGHSHGGGHGHSHGIGGGTQKKKSKKNRLLNNQGQDIEDLGGENGKNKKGVRNINVHSAYIHVLGDCFQSIGVMVASCIIWVHPHWKIADPITTLIFSVIVLGTTIKLLRESLGVLMEGVPPEIDVSEVKGDLSEIEGVTEVHDLHIWSITLGRPALSVHLTILPTIDPEEILSIANKILLEDYEINHTTIQIEKPLVKDKCKDHSCPPPKPKKKKIKNDNLSSPPNQ
What is the function of this protein?
May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces.
What are the official names of this protein?
Probable zinc transporter protein DDB_G0283629.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACP_EDWI9
Sequence: MSTIEERVKKIIVEQLGVKEDEVVNSASFVDDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYIEAANK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_BURM9
Sequence: MSDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVKKASPSKGVLREHFVPADIARSYAQHGAACLSVLTDERFFQGSARYLEQARAACTLPVLRKDFIVDAYQLLEARAMGADAILLIAAALDTPLMIDLEAYAHSLGLAVLVEVHNRGELDEALKLKTPFVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTFLVGEAFMRAENPGAELARMFF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: PUR2_THEMA
Sequence: MKAVRVHILGSGGREHAIGWAFAKQGYEVHFYPGNAGTKRDGTNHPYEGEKTLKAIPEEDIVIPGSEEFLVEGVSNWRSNVFGPVKEVARLEGSKVYAKRFMKKYGIRTARFEVAETPEELREKIKKFSPPYVIKADGLARGKGVLILDSKEETIEKGSKLIIGELIKGVKGPVVIDEFLAGNELSAMAVVNGRNFVILPFVRDYKRLMDGDRGPNTGGMGSWGPVEIPSDTIKKIEELFDKTLWGVEKEGYAYRGFLYLGLMLHDGDPYILEYNVRLGDPETEVIVTLNPEGFVNAVLEGYRGGKMEPVEPRGFAVDVVLAARGYPDAPEKGKEITLPEEGLIFFAGVAEKDGKLVTNGGRVLHCMGTGETKEEARRKAYELAEKVHFEGKTYRRDIAL
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: ATI3_VACCC
Sequence: MSNQNIPQLSEYQTSVSQVAVTPPPKPETPQIFEYQTSDSIVNNPRPFYNSDLEFDDIDMYLLPN
What are the official names of this protein?
7 kDa A-type inclusion protein.
Protein: PIMT_PARDP
Sequence: MSDDPETAERKMRFLFALRQRGVTDPRVLEAMERIDRGEFVRGHFEDRAYDDTPLPIPCGQTISQPSVVGLMTQALEVGPRDKVLEIGTGSGYQAAVLSLLCRRVYTIDRHRRLVAEAEALFRHLGLPNITALVGDGSRGLPEQAPFDRIMVTAAAEDPPGPLLAQLKIGGIMVVPVGQSDAVQTLIRVRRGENGFDYDELRQVRFVPLVEGLGQT
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_YERPS
Sequence: MTENRQLGALLAACHWIGEKGWCPATGGNMSLRLDLAHCLITESGKDKGSLAAEDFLLVETANNHVPSGRTPSAETGLHTLLYRLYPEIQAVLHTHSVNATVLSRVERSNALVLQGYEMQKSLSGQRSHLDAVVIPIFDNDQDIPVLAQRVAAYADNRPLQYGFLVRGHGLYCWGNSVVEARRHLEGLEFLFQCELQRRLFDVNSNVDVKPNVDVNPNVEAK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: HEM3_GEOKA
Sequence: MRNIVVGSRRSKLALTQTKWVINELKQLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLFVKEIEHELLAGGIDMAVHSMKDMPAVLPEGLVIGAVSRREDARDVLVSKGNRMLSDLPPGSVIGTSSLRRSAQLLAYRPDLTIKWIRGNIDTRLAKLESEEYDAIVLAAAGLARMGWGDDVISDYLPFDVCVPAVGQGALAVECREDDDELRQWLSRLNDEQTERAVRAERAFLQQMEGGCQVPIAGYAEVKEGTVRLTALVASPDGKEMYKEIVTGADPEAVGRQAAAILSEQGAKALIERVKKELGD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: E313_ADECR
Sequence: MAMTEESVDQVEVNCLCVQHGQSCNNTRCFVKEGLRANWFYNPVLEEFAIPDSYQEGHGVNVKITFSHRSRNLRHNGHDVICSYSHLGSHISIRCTCNKPRPHLSLIEAACSMYNLD
What are the official names of this protein?
Early E3 13.3 kDa protein.
Protein: CSPL4_SORBI
Sequence: MSHGHGGGAADNGVSPGNVPVCYYGAAGRVPAALERRVRAAELFMRCAACGLAVLAAALLGADRQTRTIFSVEKTARFTDMQSLVFLVIANGMAACYSLLQGARCLVSILTGGVLINRPMAWAIFSCDQVMAYFTITAVAVAMEAAMIGKYGSLQFQWMNTCHFYKRFCAQAGGAVACAVAASLNMVGISLVSAFNLFRLYGSGKGRK
What are the official names of this protein?
CASP-like protein 2U2, SbCASPL2U2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UXB1_YEASX
Sequence: XNSQXEXPVA
What are the official names of this protein?
Unknown protein from spot 2D-000JYC of 2D-PAGE.
Protein: UL106_HCMVA
Sequence: MMTDRTERRRRLTHAACTPSANNQRTTRLPPHPGFFSWSNPACDDGLFLYRTTVSRGVDTQRRRRSHPGFFSCRYHPSTVSLARRHRGPGKRISLRTEISKDADPISTVTETRWFLLNFQCIEPP
What are the official names of this protein?
Uncharacterized protein UL106.
Protein: Y395_PASMU
Sequence: MKFRFAALASVALLTSTVSVAGVVTSSSNIDFLAIDGQKPSKSLLKEKRSFNVSDTLPHQVVVRVAEIIRTGSDRSLYESDPIVVTFQGTTDDIIISAPRLETERDANAFKKSPKITVKTVSGVEIATKQEYLKQEGFLPGINLIENLSEYNASGAPAAVARLASTTMPAAIPGFGKAQKGKITVQGENVAEQMLQYWYQQADKETQQRFLSWAKGQK
What are the official names of this protein?
UPF0319 protein PM0395.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: S61A1_HUMAN
Sequence: MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251).  May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251).  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).  The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:8616892).  Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633).  Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
What are the official names of this protein?
Protein transport protein Sec61 subunit alpha isoform 1, Sec61 alpha-1.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Protein: LEU1_PSEPF
Sequence: MSMLKDPSSKYRAFPVINLPDRTWPSKTIDAAPIWCSSDLRDGNQSLIEPMDAVKKLRFWKTLVQVGVKEIEASFPAASQTDFDFVRTLIEDGHIPDDTTIQVLTQGREDLIERTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKDGIKAIAVNAAKLFVKYAAMQPDTEWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPEHKIILNLPATVECATPNVYADQIEWFHRNINRRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGINPDLDFSDIDGVRKVVEECNQIQVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKPDTLWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQRETDRLGLEMTAQQIHALLHSEYLQANTPYALVSHRLQEENGNSAVEVEVASKGQGETNLHWRGKGNGALEALVAGLPIPVEIMDYNEHAIGAGTNAKAAAYIELRVNGERAVHGVGIDENITTASFKALFSALNRSLSQPEAKAA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: ISPF_SALPA
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLMKAAK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: AUSI_ASPCI
Sequence: MLHETTNLAPLGQPWIAGLVVVSAVLYLLYSTQRWRANNIPLLNDAGPFDFLQATAVNRFRRDARQLIKSGFDSHRDVFAMRTDVGVELFASPEYADQFRNHPSLKVFPFTAKMHHGHLPGFELCRSQPVEDRIFIESVRVQLAQSLGKLIQPLASDIGQAISDRWPSESGWEEIALGSVVERTISQGTSSVYCLDKAWPEFVVKMEMALGMASAALSAWPVMLRRIVAKFLPECLELYRTMDAGRELMSRDMRRRTALQASTGEAPLNFFEWFKEASHGEEHDELILNLRIAFASMHGLCDHLVKILLRLSEDPQLVDDLRKEVIQVYKTHGWSKTALYHLKLMDSAFKEVQRVDPILFGMPTPISLVQTHSNYETAVGRVAVDDVTLKDGLVIRKGQSIRISGHTMWDEDKYPDAAHFDAYRFYKLRQAPGQENTAQFTSPTSDHLGFGYGGRACPGRFFAAAVLKISLCHLLMKYDIKPADGETGPHVWEFAAAINANMAAKVLVRRRQPEIQL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausI, Austinoid biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.