PharMolix/UniProtQA huggingface dataset:
Protein: SUCC_BDEBA
Sequence: MNIHEYQAKEVLRKFGVATLKGKLAHSPEEAVAAAKEIGGSVWVVKAQIHAGGRGKGGGVKVAKSLDEVSEFTKKMIGMTLVTHQTGPEGKVVQKVFIEQGCNIAKEYYVACLIDRATGRAAMMASSEGGMDIEEVAEHNPDAIKKVDIDPTVGLMPFQARELAFQIGMEPAIVNKAVKFFAGLYNAFVATDCSIAEINPLVVTKEGDVLCLDAKMNFDSNSLFRHPDIVEMRDLNEEEPSEIEASKFDLAFIKLDGNIGCLVNGAGLAMATLDIIKLHGAEPANFLDVGGGANKEKVTEAFKIILKDKNVKGILVNIFGGIMKCDIIAEGVIAASKELGLKVPLVVRLEGTNVELGKKMLKESGLNITPADNLTDAAKKIVAAIKG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: FLGI_SALTI
Sequence: MYVFKALAGIVLALVATLAHAERIRDLTSVQGVRENSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASYPPFARQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAIIERELPTQFGAGNTINLQLNDEDFTMAQQITDAINRARGYGSATALDARTVQVRVPSGNSSQVRFLADIQNMEVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQLNVNQPNTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSANLNSVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: GDA1_KLULA
Sequence: MHINSVVRNYRFLIGALTALMLLLLLRSSASPQVGSLANSNKVDTPDGLKVPGASSPISQNINEDSQKQTAKDHTSQNLESGSNSLSKSQCTEGHKYVVMIDAGSTGSRVHVYEFDVCTQPPTLINETFEMLKPGLSSFDIDAVGAAKSLDPLLKIAMDAVPKDKRNCTPVAVKATAGLRMLGDEKSSKILAQVRKHLEQDYPFPVVDGDGVSIMDGEEEGVYAWVTANYLLGNIGAGSKLPTAAVFDLGGGSTQIVFEPSFPPNEKMVDGEHKYELSFGGHDYTLYQFSHLGYGLMQGRNKINTELVNVAISSGTITKGQTARTYELSSPCLPPGTTAEGEKVKISDDEIYTVNFKGPKVPAGPQCRYLADKILNKDAKCNTPPCSFNGIHQPSLVHTFKETSDLYVFSYFYDRTQPLGLPLSFTLQELQDLARTVCNGEEVWESVFSGIEGSLSELSKEPQWCLDLNFQVSLLHTGYDIPLQRELRTAKTIANNELGWCLGASLPLLESANWSCKVSKVE
What is the function of this protein?
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
What are the official names of this protein?
Guanosine-diphosphatase, GDPase.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
Protein: MTLD_ALKCK
Sequence: MKAVHFGAGNIGRGFIGALLVDAGYEVTFVDVNEKIIDALNERNEYKVTVAGERKETETVTNVRGINSKTNEKEAIDAIAEADIVTTAVGPTVLPYIAKTIAQGLKQRTASKPVNMIACENAIRATSQLKKDVLSHLSEEETTALLKDAGFADAAVDRIVPNVQSDDILHVTVEPFFEWVVEKPALKGDAVQLGKAVLVEDLAPYIERKLFTVNTGHAVAAYVGYRKGKKTIKEALADDYIKHRVRGALNETKAMLVEEYQFDAEAHEDYIDKILLRFQNPHLEDLVERVGRGPIRKLGPADRLVKPAKYLAEKGLHPESLAETIFDALHFYAEGDPESEELRALVDEKGYVDAFCEISKLEKDHPLVEIVAKE
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: INO1_MACFA
Sequence: MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKIIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQRRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYAPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDADPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACLGLPPQNHMLLEHKMERPGPVLKRVGPVAAACPVLNKKGPVPAATNGCTGDANGHLQVEEPQMPTT
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).
What are the official names of this protein?
Inositol-3-phosphate synthase 1, IPS 1, Myo-inositol 1-phosphate synthase, MI-1-P synthase, MIP synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_RHOPS
Sequence: MASEDPSVSGVSGRYATALFELARDEKVIDAVKADLDKFSAMLVESPELLRLVRSPVFGAEAQTKALGAVLDKAGIAGISANFLKLLAANRRLFVVADVIGAYRALVARFKGEATADVTVAETLSDKNLEALKLALKSVTGKDVTLNINVDPAIIGGLVVKLGSRMVDSSIRTKLNSIKHAMKEAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NFI_PYRHO
Sequence: MLERIANIQKKLSKSIVERKINEVRKVAAVDVSYKEEKARAALVITTFPEGEVLKTKVIETTVSFPYIPTFFFLRETKPILIATKGETFDVLIVEGHGKAHPRGYGLASHIGVVLRKPTIGVAKRLLKNTPKDTYKKVGKVYVSVGNLITLEDATKIIRAILDESGYPKPLKLADKLSKGRIYEVKNTPSPNRSRKKRGNRGKDNNNSQGN
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WEL1_ARATH
Sequence: MEDLKTTDALSLPVVSDNGGIIEPELQLPQAIPTELENNEEENGTIQQSQSEEDSAENGKIYMDDTFLPSKSQVKETQDSPTTPSFVSPSAEIVLPRVNTKYEAEGTTRNAVSPRPLYSPRSIGSPRALLSPRFAGSSSPLSNGTPISMDSFRDSIDTASPFESVKEAVSKFGGITDWKAHRMKVLERRNFVEQELDKIQEEIPEYKKKSEMVEMSKMLAVEELESTKRLIEELKLNLEKAETEEQQAKQDSELAKLRVQEMEQGIADEASVASKAQLEVAQARHTSAISELESVKEELQTLQNEYDALVKEKDLAVKEAEEAVIASKEVERKVEELTIELIATKESLECAHSSHLEAEEHRIGAAMLRDQETHRWEKELKQAEEELQRLKQHLVSTKELQVKLEFASALLLDLKKELADHKESSKVKEETSETVVTNIEISLQEKTTDIQKAVASAKKELEEVNANVEKATSEVNCLKVASSSLRLEIDKEKSALDSLKQREGMASVTVASLEAEIDITRCEIALVKSKEKETREEMVELPKQLQQASQEADEAKSFAELAREELRKSQEEAEQAKAGASTMESRLFAAQKEIEAIKASERLALAAIKALQESESSSKENAVDSPRTVTLTIEEYYELSKRAHEAEEAANARVAAAVSEVGEAKETEKRSLEKLEEVNKEMVERKATLAGAMEKAEKAKEGKLGVEQELRKWREVSEKKRKNGSSHGKSIQGSKEKEAETSVSNETETNPIPQVNPVKKKKKLFPRFFMFLMKKKSHK
What are the official names of this protein?
Protein WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT-like 1, Protein WEL1.
What is the protein family that this protein belongs to?
Belongs to the WEB family.
Protein: MURC_PORG3
Sequence: MKRVYFIGIGGIGMSAIARYFHARGFNVCGYDLTPSPITDQLIKEGIEVHFSDDLNMIPKAFFSPTDSLIVYTPAVPADHSELTYFRSNGYRVVKRAEILGEITLIERALCVAGTHGKTTTSTLLAHLLKQSHVDCNAFLGGISNNYQSNLLLSDKSDLVVVEADEFDRSFHHLKPFMAIITSADPDHMDIYGTAENYRDSFEHFTSLIQSGGALVLKYGAPVNPRLGSDVSLFTYSSDDRQADYFASDITIRDGRLFFTWHYPGGQLEEVELGVPVHINVENAVAAMAIAHLNGVTVEELRSGIASFKGSHRRFEKVLDTERVVLIDDYAHHPVELDAAIRSVREIYSRKHIMGIFQPHLYSRTADFYQDFARSLSMLDEVVLLDIYPARELPLPGVTSRLILDLIENPNKTLVSKNDLLDYLHGNEIPDVVLILGAGDIDRLVIPVKQYLQTLC
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_RICRO
Sequence: MSRRHAAEKRVILPDMKYNSILLSRFINNIMKEGKKALAEKIVYSAFNKIEKKHRVDPYQAFNNAMHNVKPHLEVTSVRVGGANYQVPTHVDERRGYALASRWIINAASKRSEKMMIDKLAEELFEASNNRGVAIKKKEDTHKMAEANKAFSHFSPKKMK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RB1BV_BETVU
Sequence: MAAPPARARADYDYLIKLLLIGDSGVGKSCLLLRFSDGSFTTSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDESSFNNIRNWIRNIEQHASDNVNKILVGNKADMDESKRAVPTAKGQALADEYGIKFFETSAKTNLNVEEVFFSIARDIKQRLADSDTRQEAQPSITIKPADQSGNQAAAKSACCGS
What are the official names of this protein?
Ras-related protein RAB1BV.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: FBX50_HUMAN
Sequence: MEEVREGHALGGGMEADGPASLQELPPSPRSPSPPPSPPPLPSPPSLPSPAAPEAPELPEPAQPSEAHARQLLLEEWGPLSGGLELPQRLTWKLLLLRRPLYRNLLRSPNPEGINIYEPAPPTGPTQRPLETLGNFRGWYIRTEKLQQNQSWTVKQQCVDLLAEGLWEELLDDEQPAITVMDWFEDSRLDACVYELHVWLLAADRRTVIAQHHVAPRTSGRGPPGRWVQVSHVFRHYGPGVRFIHFLHKAKNRMEPGGLRRTRVTDSSVSVQLRE
What is the function of this protein?
Promotes cell proliferation.
What are the official names of this protein?
F-box only protein 50, NCC receptor protein 1 homolog, NCCRP-1, Non-specific cytotoxic cell receptor protein 1 homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM2_ORYSI
Sequence: MADQLTDEQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMAKKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2, CaM-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: SYR_MYCSJ
Sequence: MTPADLADLLRTTATAVLTERDLDTAALPATVTVERPRNPEHGDYATNLALQVGKKVGVNPRELAGWLAEALTAAAGIASAEVAGPGFVNLRIEAAAQNVIVGDIITSAERYGHSAALAERNINLEFVSANPTGPIHIGGTRWAAVGDALGRLLATQGAAVVREYYFNDHGAQIDRFVSSLIAAAKGEPTPEDGYAGSYIGDIAAQVLAKDPGALELPDGEMRETFRAIGVDLMFDHIKISLHDFGTDFDVFTHEDSMHTSGRVEEAIARLRENGAIYEKDGATWLRTTDFGDDKDRVVIKSDGAPAYIAGDLAYFLDKRQRGFDLCIYMLGADHHGYIARLKAAAAALGDDPDTVEVMIGQMVNLVRDGQPVRMSKRAGTVITLDDLVEAIGVDAARYSLIRSSVDTPIDIDLALWSSASNENPVYYVQYAHARLSALARNAADLGVVADTARLDLLTHDKEGTLIRNLGEFPRVLESAAALREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEAPGSLHQARLALCQATRQVIANGLAILGVSAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB32G_ORYSJ
Sequence: MAREIHKIASLRRESSLWRRGDDGVYFSRSSTGASSSRFRDEEDDEEALRWAALERLPTRDRVRRGILLQAAEGNGEKVEVDVGRMGARESRALIARLIRAADDDHALFLLKLKDRMDRVGIDYPTIEVRFEKLEVEAEVHVGNRGLPTLLNSIINTVQAIGNALHISPTRKQPMTVLHDVSGIIKPRRMTLLLGPPGSGKTTLLLALAGKLEDNLKVSGKVTYNGHGMDEFVPQRTAAYISQHDLHIGEMTVRETLAFSARCQGVGSRYDMLTELSRREKAENIKPDQDIDVYMKASAIGGQESSVVTEYILKILGLDICADTVVGNDMLRGVSGGQRKRVTTGEMLVGPARALFMDEISTGLDSSTTYQIVNSIGQTIRILGGTAVISLLQPAPETYNLFDDIILLSDGQIVYQGAREHVLEFFELMGFRCPQRKGVADFLQEVTSKKDQEQYWYRNDIPYSFVPVKQFADAFRSFHVGQSIQNELSEPFDRSRSHPASLATSKFGVSWMALLKANIDRELLLMKRNSFVYIFKAANLTLTAFLVMTTFLRTKMRHDTTYGTIYMGALYFALDTIMFNGFAELGMTVMKLPVFFKQRDLLFFPAWTYTIPSWILQIPVTFFEVGVYVFTTYYVVGFDPNVSRFFKQYLLLVALNQMSSSLFRFIAGIGRDMVVSQTFGPLSLLAFTALGGFILARPDVKKWWIWGYWISPLSYAQNAISTNEFLGRSWNKSFPGQNDTVGISILKSRGIFTEAKWYWIGFGALIGYTLLFNLLYTVALSFLKPLGDSYPSVPEDALKEKRANQTGEILDSCEEKKSRKKEQSQSVNQKHWNNTAESSQIRQGILPFAQLSLSFNDIKYSVDMPEAMTAQGVTEERLLLLKGVSGSFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGDITISGYPKKQETFARISGYCEQNDIHSPHVTVYESLVFSAWMRLPSEVDSETRKMFIEEVMELVELTSLRGALVGLPGVNGLSTEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRKTVDTGRTVVCTIHQPSIDIFEAFDELFLMKRGGEEIYVGPLGQNSSKLIEYFEGIEGISKIKDGYNPATWMLEVTSTTQEEMLGIDFSEIYKRSELYQRNKELIQDLSTPTPGSTDLHFPTQYSRSFFTQCIACLWKHKLSYWRNPSYTAVRLLFTIIIALLFGTMFWDLGRKTKKEQDLFNAVGSMYAAVLYIGIQNSGCVQPVVVVERTVFYRERAAGMYSGFPYAFGQVAIELPYILVQTLVYGVLVYSMIGFEWTVAKFIWYLFFMYFTLLYFTFFGMMAVGLTPNESIAAIISPAIYNAWNLFSGYLIPRPKIPVWWRWYCWICPVAWTLYGLVASQFGNIQTKLDGKDQTVAQFITEYYGFHHDLLWLVAVVHVVFTVMFAFLFSFAIMKFNFQRR
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 32, OsABCG32, Pleiotropic drug resistance protein 16, OsPDR16.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYRF_PROMP
Sequence: MKKFNTEEKIILAIDGLDIFQAKVLLERCPNIKWVKVGLELFTREGPSVIKILKNLNKKIFLDLKFHDIPNTMSAACYEVSKLGVDIISVHASAGSKALTASKKASLEGAKIATVNAPCVIGITVLTSLSSEEFQTDLDRKNSIEENVIRLAKLSFDAGLDGCVCSPLEAKILRSMYKNNFELITPGIRTNIQKKDDQNRIMTPFEAISNGSSKLVIGRAITKAKDPNKAFLDICESIC
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: MAP22_ASPNC
Sequence: MAAQASEKLQKLDLNGQSGDAEADAPAAGQTQAGEAEDDSDDDEVEDGNAAGEGAASGGGAKVQSSPPRVPLSTLFAGKEYPEGEIVEYQNENSYRTTNEEKRYLDRMKNDFLQEYRQAAEVHRQVRQYAQKTIKPGQTLTEIAEGIEESVRALTGHQGLEEGDNLKGGMGFPCGLSINHCAAHYTPNAGNKMVLQQGDVMKVDFGAHINGRIVDSAFTVAFDPVYDPLLAAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVEINGTMYPVKCIRNLNGHNIDQHIIHGGKSVPIVKGGDQTKMEEGEVFAIETFGSTGKGYVREDMETSHYALIPDHSQVPLRLSSAKNLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSSGIVQDYPPLCDIKGSYTAQYEHTIVLRPNVKEVISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-2, MAP 2-2, MetAP 2-2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_XANOP
Sequence: MAIRQLPEMLINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGIAPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQPHYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRTLQDALAHTRAGATPNSIGSDGAGYTGATAGEMGNIASGGPANHGNAPGRSGSAYSYANWTPSQTPLGLRVDEARAAYSALYAPPPRNAPQSTGMPSMAGTGLPATSEDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIVYERLKNAHDSIGLHAQPLLVPMTLAVGEREADTAEREADTLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLGDLREHGQSCRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DHPS1_MYCTU
Sequence: MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRADVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVISALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG
What is the function of this protein?
Is involved in the bioactivation of the antituberculous drug para-aminosalicylic acid (PAS).  PAS is a close structural analog of pABA and acts as an alternative substrate for DHPS, leading to hydroxy-dihydropteroate (H2PtePAS).  Metabolomic studies show that PAS, despite its in vitro activity as a competitive inhibitor of DHPS, does not inhibit growth of M. tuberculosis by inhibiting DHPS.  PAS exerts its antimycobacterial activity through its effects on M. tuberculosis folate metabolism downstream of DHPS.  PAS poisons folate-dependent pathways not only by serving as a replacement substrate for DHPS but also by the products of that reaction serving as replacement substrates and/or inhibitors of subsequent enzymes.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: SYC_DEHMC
Sequence: MKIYNTLSGKLEKFVPLENGKVKMYVCGITPQSEPHIGHAMSYINFDVIRRYLTYKGYRVKYIQNFTDIDDKIIAKANAQGIEPSTLAERNIGVFLDAMAALNITPADYYPRATQEVPKIIEMVSGLIEKGYAYAVGGSVYLRVQKVDGYGKLSHRTLEQMMAGARVEIDEEKEYPMDFALWKATKPGEPSWESPWGLGRPGWHIECSAMSLRYLGEQIDIHGGGQDLIFPHHENEIAQSECFSGVKPFVKYWLHNGLLKLGEEKMSKSLGNLVTIKEALSRYSADALRIFVLSSSYRNPLTYSEEALEAAEKGAERLRQTAARKDNPQFKETAVDTKAYRERFTQYMDNDFNTSAALATIFDLSRELNRIEGEAGKSTDGQKLFKELADILGLSLIVAESKTGTDVAPFIELLIELRKDLRVAKQYQLADKIRTSLDTAGILLEDSAGGTVWKVKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R212B_MOUSE
Sequence: MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCMTLEKCAVCGNLCKHLALSDNLKPQEKKFFKSPVETALQCFSHISQVWCFQKKQTDLLIAFYKDRITKLEAAVKEAQEMAASQNKELSALRKENGELKKILDILKGSPSCYYGSRLTTPRPVGITSPSQSVAPRPSSHHSSQVVSRSSSMESIPYTVAGMGHVEQGSRGLHVRSTPGDSYTETPSPASTHSLSYRPSSASSGQGVSFRPFFSGDSGHTRVLTPNNSGRRESRTTPESLPGFQLPVLQTFYQQRQMGLARKDGWNISR
What are the official names of this protein?
RING finger protein 212B.
Protein: RS2_PYRAE
Sequence: MTEEMQYEYLVPLEKYLSAGVRLGTRLSNKYLEDRGFIFAVRPDGLRIFDIKKIDERLKIAAKFIARYRPERVLVHTTRPYGFKPVQMFCKFVGCKALTGRFIPGTLTNPNLPHYQEVDLLFVVDPKLDAQAVAEAAKMGIPVIALVDTDTPHQYIDFMIPCNNKGRKSLALIFWILARQVLRERGELKPDQDLPVPPEEFETKLVQS
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RLMN_BACCQ
Sequence: METTVRKQKKNLETKKPSIYSLQLHEMQDWLKEQGEPKFRAGQIFDWLYKKRVKNYEDMSNLSKGLREKLSNSFDITTLNTLVKQTSSDGTIKFLFQLYDGYSIETVLMRHEYGNSICVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVEVQRALDESEERVSSLVVMGIGEPFDNYDNLMGFLRIINHEKGLHIGARHMTVSTSGIIPKIYKFAEEDLQINFAISLHAPNSELRSKLMPINRAYKLPDLMEAIKYYVNRTGRRITFEYGLFGGENDQVEHAEELAALLKGVKCHVNLIPVNYVPERDYVRTPREQIFLFEKTLKDRGVNVTIRREQGHDIDAACGQLRAKERKEETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_ECO24
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNF37_HUMAN
Sequence: MVINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRINIDLTAGGGQNVTGLEMYTSASSSRVSWNTPQCRTLGPAEPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHVAHLRICITHVTGGGIPCIKRLEVWGQPAKTCSQEVIDSILLVTSENLPQDVALQAPALPMESDCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATWGRVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSIPGCHLLGRAQTALAVIPSSIVLPSQKRKIEQAEHVPDSNFGVNASCFSATSPLVLPTTSEHTAKKMKATNEPSLTHMDCSTGPLSHEQKLSQSLEIALASTLGSMPSFTARLTRGQLQHLGTRGSNTSWRPGTGSEQPGSILGPECASCKRVFSPYFKKEPVYQLPCGHLLCRPCLGEKQRSLPMTCTACQRPVASQDVLRVHF
What is the function of this protein?
May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.
What are the official names of this protein?
RING finger protein 37, RING-type E3 ubiquitin transferase RNF37, U-box domain-containing protein 5, UbcM4-interacting protein 5, hUIP5, Ubiquitin-conjugating enzyme 7-interacting protein 5.
What are the subcellular locations of this protein?
Nucleus. Note=Enriched in nuclear bodies.
Protein: GREA_STAA3
Sequence: MENQKQYPMTQEGFEKLERELEELKTVKRPEVVEKIKVARSFGDLSENSEYDAAKDEQGFIEQDIQRIEHMLRNALIIEDTGDNNVVKIGKTVTFVELPGDEEESYQIVGSAESDAFNGKISNESPMAKALIGKGLDDEVRVPLPNGGEMNVKIVNIQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RIHC_SALA4
Sequence: MTASLHIILDTDPGIDDAAAIAAALFAPELDLQLITTVAGNVSVEKTTRNALQLLHFWDADVPLAQGAATPLLRPLRDAAYVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPMTLVAIGPLTNIALLLMHYPECACNIRRLVLMGGSAGRGNFTPNAEFNIAVDPEAAAHVFRSGIEIVMCGLDVTNQAMLSPDFLSKLPALNRTGKMLHSLFNHYRSGSMRTGVRMHDLCAIAWLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAEVFACAP
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: RL18_SALSV
Sequence: MDKKSARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.