PharMolix/UniProtQA huggingface dataset:
Protein: S100B_BOVIN
Sequence: MSELEKAVVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDSDGDGECDFQEFMAFVAMITTACHEFFEHE
What is the function of this protein?
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:6615778, PubMed:3722149).  Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:6615778, PubMed:3722149).  Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (PubMed:3722149).  Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity).  Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity).  Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (PubMed:14661952).  Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity).  Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).  May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
What are the official names of this protein?
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y3985_RICRS
Sequence: MLAIISSAKTLNFEKLAPKTELTIPVFLTLTNKLLATLQSYSENQLSKIMNISAKLAHINKERFKDFDNQESKAAIFAYAGDVFNNIHIEKLTNHALNFLQSHLLIISGLYGVLKPLDTIKPYRLEMATKLNEINLTNFWQDEVTNYINKILAKQENKYLLNLASQEYSSVINPNKLKYQLVNVHFKENRNGKLSTIGINAKKARGAMVKVIANNLIDSPELLKNFSYLGYAFSTKHSSDNELVFIKS
What are the official names of this protein?
UPF0246 protein A1G_03985.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: ATP6_STAS1
Sequence: MNHKDPLVSWNVFGLDVVFNLSSIMMLIITAVIVFVIAIICTRNLKKRPTGKQNFIEWVFDFVRGIIESNMAWSKGGQFHFLAVTLIFFIFVSNMLGLPFQLISGHTLWWKSPTADATVTLTLSTLIILLTHFYGVRMKGTKGYFQNYTKPIFLLPINIFEEFTSTLTLGLRLYGNIFAGELLLGLLAGLVTGDSTRAWGWIIGLPGLVVWQGFSIFIGTIQAYIFVMLSMVYMSHKVQDSH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BIOB_PSESM
Sequence: MSASTTATLRHDWTLAEVRALFVQPFNDLLFQAQTLHRAHFDANRVQVSTLLSIKTGACPEDCKYCPQSGHYNTGLEKEKLLEVQKVLEEAARAKSIGSTRFCMGAAWKHPSAKDMPYVLEMVKGVKAMGLETCMTLGRLDQEQTEALATAGLDYYNHNLDTSPEFYGSIITTRTYGERLQTLAYVRDAGMKICSGGILGMGESLDDRAGLLIQLANLPEHPESVPINMLVKVAGTPLENAEDVDPFDFIRMLAVARILMPQSHVRLSAGREAMNEQMQALAFFAGANSIFYGDKLLTTANPQADKDMLLFSRLGIKPEAGEGHADEVHQAAIEQALVEQQSSAMFYDAASA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MEND_PARUW
Sequence: MNHELALHVIEQALQYGIKEFCVAPGARNAAFVYLLAQIPTIKVYYWSEERSAAFFAVGRIKATHQPIAVVTTSGTAVAELLPATIEAYYTSLPLLLITADRPRRFRLSGAPQSIEQVGIFSCYTILEKDLAENEFFQLDQWSGRGPCHLNVCFEEPSKNDNQECARSFSMGIFTPKPILCDSHLLDEFIQKCQFPLVIVGALNQNETTPILSFLRHLKAPVYLEAQSGLRENSLLENLRIESVEDVWNCSSQHGYPIDGILRIGGIPTARLWRDLEETNNVKVCSISENPFAGLTNGNIIHTSLREFFKNYRLSFKPIYSFQAWKDANRSYQLELLKLFEEEPLAELSLFHLLSKKIPEESKIYVGNSLPIREWDQAADWTNKHFQVFANRGANGIEGQLSTFLGLASPEQNNWAILGDLTTLYDMIAPWVIHQIQPLKVNVVVVNNSGGQIFAPKFAHLSFLNSHQLNFKAFADFWGWEYDCWHEIPTTILGSQTSRLIELVPDPSATDRLRKKMQRM
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: ATG11_KLUMD
Sequence: MPPCELISASNGASFQLSDLYFPSFLDLKQFVGETFHISVDDILLLLSYGIILKRSQWDSTKIRSEGLKSIYVFDRKLFNEDIELAVEERFRLFKPLDSPMSDLSEVDRNIVLRNMGWLKALQSDVEFFQLSIEQTRKEVQNMLDCGVVMLEYLKNYCHEVETLYNSHVGFLNKLHEHSASSQWREVYDSVLEAVKIDQQRSLASFFQIDELNQIEAKIRHTDHELNMKLKELKKTIDTCYQHRKTLVSELENIKSISVVSPDCMDKQMTDKFNEMAQELEAASNEWVQNSENNDHISEKVKQMKDSHIPNLQTISQSLFNKASKIIETKTDMQRQLRSLYISVAKSQMDIIEVKSTLTKDMKSDMKLLQTYELQLSQVLDLPMCYGLYLIELYRQQLWMDNYTHIKDQHESALQVMLQEEIHQRKMWYRDFQWISKFLKVDQSLPSTVSITPLKALRRVDLLQINEYFNQLSSAKVSETTLNVLKSKLSQAEMDNMLPELSEQSSNDTGAAIEGYKSRIKKLENLLLDAQFQRYDSWPSGILNKEIAMVQMFRNNTLNNKVQRSSTDDISNSIQQSYSKTLGDVQNLQKAISEYSGLTDTLKEELSTLKSQISNMEVEKNAYKESMANLNKELSNLLINRENFHTEMMERSNDFKKHLALVGEENEQLTKQNQQLSNEIIESQKKYEELNKIKDDLLLNMANQETQAEQERAALQEEIESLKKEVGQLQMAKSSLTESEELLGINKQLEKTLYDVFQGSIFLLESIGLLLSKDIDGKFQIVRVKGLRKDLDSSVIDMNGSLVKSVVSHEIKDTFESIKDSLDYKPHENFISYTEKLFGNQLFEMAVIRRFNDIESLAKKLRKENKNKKILLQKYTNDKITINNFQLGDLALFLPINDQELLLNSSVSSLNSSFSSIDLNSSTQSMIPPRVIPNRVEPASNTNNSNPSSVPEDMGSPNMNRVNTMGNVKVNANIGSNNSNNNYVNTGNANGNNKPETNIDTTSSTNAESPKKQIVWAIFTATNTEVKYILRNTMSNYELLREKEWAVGRITALEKNIVMEGARNPFKFPQNTVWFEVDALFNLS
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy (PubMed:26442587).  Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity).  Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity).  Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity).  Recruits also the ATG19-prAPE1 complex to the PAS (By similarity).  Required for the Cvt vesicles completion (By similarity).
What are the official names of this protein?
Autophagy-related protein 11.
What is the protein family that this protein belongs to?
Belongs to the ATG11 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole (By similarity).
Protein: SCX3_CENNO
Sequence: KEGYLVELGTGCKYECFKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTQLYEQAVVWPLKNKTCR
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Toxin Cn3, Toxin 3, Toxin II.9.2.3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RECR_ROSDO
Sequence: MSSTKDIDALIDLMAKLPGLGPRSARRTVLHLIRKRSLLLIPLADTLQTVAETARECLNCGNVGTTDVCDICTCEKRANGELCVVEDVADLWAMERSGIFKGRYHVLGGTLSALDAVGPQELRIPRLLDRVPSEGITEVILALNATIDGQTTAHYIADNLEGQVRLTSLAQGVPIGGELDYLDDGTITAAMRARKSF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: HIS7_METTH
Sequence: MITMRRSMKTRETLETHVKVDLEIDGSGKSSVNTGLGFLDHMLESVARHGLLDLEVEARGDLEVDDHHTVEDVALTLGEALREALGDKSGIRRMAHAMVPMDDALATVALDLSGRPYTVLELEFDDAVIGDVKSQNIGHFIESLAVSAAMNIHASVRGRNDHHKAEALFKALALAIRDAVRVEHGEIPSTKGKL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTE1_COCIM
Sequence: MNLTTTMPAAVAPDPPAQLAVSSRSLSDSSDAAGASRTSSSCRASSPSHCPTHAWNPDPPPSSLQPVFSFSPSLPPPCPSPAISSCPPNTLSPPNLLQGIVSQLAMASYIGRLLLYLFQVVPSLLYWAITFTTITVPTALFTLFSMSLTFTMNFTTLLIIVLLLVSTVSWFIRYRFLNIYSRLPPEPQRKEPEIDLFPDSQDGDSKPGLSNYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLLLEEEKGFCLVVDGLVQIFVKSIQERDDDRDGWQLDEAVEDSVDEDDEIRRRGHQGYQLLTEVKNGASMSSLFSILSLFSEDIKLRHNEDMESSSSSFNNVPAPDSNPMSPALLLESPTRVSFPDQRDIPTQPSADTLPKVSPLALEGSPGPFEHDPKPRGHRRKRPSRPKRAKSVHPDILARAMVDTTIAIIPASAFRRLTRVYPKATAHIIQVILTRLQRVTFATAHSYLGLTTEVLSIEQQMTKYTSFDLPNHLRGAALDKLKSKFTKEKERLGPEDGTKGIALHNPALNRRRRSSSSLRKDAALHAKLTAVRGKGSASNPIRYGDHESTGVSPGDLLSTIQLSRFGPRYGSERLNGRSVFYDAASGMKTPAGGPPSPLATPGQPLFRFPAQNVTFQRQDSLDQDAIFRESILDCMMKALGLTGSTQDALRKTHNSGDASPHLVSYDSRRQKAVFNNAFGFIDPYDGFGDGDSESLMSMSVTSAGGTSPVHNLRTELQDEIEIVYFPKGSVLIEQGEHNPGLYYVIDGFLDVGIPVNEKGEDLIGSSRRPTAEDILLPITGNASRVSSTLGTAHNQRKKASRRSLYMVKPGGVEGYIGSITSYRSFTDVTAKTDVYVGFLPRAVLERIADRYPLVMLTMAKRLTTVLPRLILHIDFALEWVQVNAGQVIHHQGDESDAIYIVLNGRLRAVLDKGDGKVSVLGEYGQGDSVGELEVMTESTRPGTLHAIRDTELAKFPRTLFNSLAQEHPGITIQISKLIAQRMRHIIDNPLEKGSDKGSPDSAKPTTSTLNLRTVAVLPVTAGIPVVEFGNRLLNAFNQVGVTNGVTSLHQADILNHLGRHAFSKMGKLKLAQYLADLEERYGMVLYVGDTSVNAPWTQTCIAQADCILLVALAEGSPAIGEYERFLLGMKTTARKELVLLHAERYSQPGLTRQWLKNRMWINGGHHHIQMAFRLTAEPVHPETKRLGAVLKQRVQVIQAEIQKYTSRRIRQTPVYSTSTPVKGDFHRLARRLCGKSVGLVLGGGGARGIAHIGVIKALEEAGIPIDIIGGTSIGSFIGALYARDADVVPAYGRAKKFSGRMASMWRFALDLTYPSASYTTGHEFNRGIFKAFGNSHIEDFWLEFYCNTTNISKSRLEFHSSGYAWRYVRASMSLAGLIPPLCDEGNMLLDGGYVDNLTVARMKSLGADVIFAVDVGAIDDNTPQGYGDSLSGFWALVNRWNPFSSLPNPPTLSEIQARLAYVSSVDALERAKSTPGCLYMRPPIDAFGTLDFAKFDEIYQVGYKFGKEFLDRLKNEGGLPIQEETEEKKKLRRTMAPRRASI
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase NTE1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRYG1_MOUSE
Sequence: MALGPNCGILLFLAVSGCGHPQVSNSGSRIVGGHAAPAGTWPWQASLRLHKVHVCGGSLLSPEWVLTAAHCFSGSVNSSDYQVHLGELTVTLSPHFSTVKRIIMYTGSPGPPGSSGDIALVQLSSPVALSSQVQPVCLPEASADFYPGMQCWVTGWGYTGEGEPLKPPYNLQEAKVSVVDVKTCSQAYNSPNGSLIQPDMLCARGPGDACQDDSGGPLVCQVAGTWQQAGVVSWGEGCGRPDRPGVYARVTAYVNWIHHHIPEAGGSGMQGLPWAPLLAALFWPSLFLLLVSGVLMAKYWLSSPSHAASEL
What are the official names of this protein?
Tryptase gamma, Transmembrane tryptase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Tryptase subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SMAD3_HUMAN
Sequence: MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
What is the function of this protein?
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.  Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription.  Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription.  Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes.  This effect on wound healing appears to be hormone-sensitive.  Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
What are the official names of this protein?
Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
Protein: YR896_MIMIV
Sequence: MVTLNIYSIIKMKRFPKRNYLRKTKVSFFNRSQRHFSQHLNIDIIGPLFKITRKDEKHYNFQYNDGLNILDTPFNNDDDHCTPGKLYFSDSKNICKYLGFGDNLRKISLPIDNPDFKMTKCLYGEKYGANMLIFGEKFDLDKVETYQKMILMDIDIRAGNDNAMIIAAQKGNLEIVKFLVESGANVKSQDNCAVRLASEFGHLDVVEYLYKSGANVKADGNYAITWACKNGHLPVIEFLTSVGADIKAAQNLPIKMAAIGGHLNVIKYLVDRGANISTDNDYVFNIACRNGHTDLAEYAVSLGADIFSDGCYGIDHAIRYNHYKIVDKFIGT
What are the official names of this protein?
Putative ankyrin repeat protein R896.
Protein: MNMG_XANAC
Sequence: MSDSFYRYDVIVIGGGHAGTEAALASARAGARTLLLTHNIETVGAMSCNPAIGGIGKGHLVKEIDALGGAMARAADLAGIQWRTLNASKGPAVRATRCQADRNLYRTAIRCIVEAQPNLTVFQAAVDDLIIHHGASEADSVRGVITQTGLRFQAPSVVLTAGTFLAGKIHVGQTQYAAGRMGDPPATTLAARLRERPFAIDRLKTGTPPRIDGRTLDYGVMAEQPGDDPLPVMSFMGQVSDHPRQVSCWITQTTEQTHEIIRNALHRSPLYSGQIEGIGPRYCPSIEDKVVRFAEKTSHQIFVEPEGLEVAEIYPNGISTSLPFDVQLALVRSIHGFANAHITRPGYAIEYDFFDPRGLKASLETKAVGGLFFAGQINGTTGYEEAAAQGLLAGLNAARHVQGLPAWSPRRDEAYLGVLVDDLITHGTTEPYRMFTSRAEYRLQLREDNADARLTGVGRAMGLVDDARWARFAAKQEAVQRETARLSALWATPGNALGREVADALGVTVSRETNVLDLIKRPELTYATLMRVPTLGPGVDDAQVAEQVEISVKYAGYLDRQRDDIARQQRHETTPIPDGFDYASVRGLSIEVQQKLERVRPQHIGQAQRIPGMTPAAISLLLVHLERARRSQVA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG21_MOUSE
Sequence: MMATHWTGLPEEDGDKLKACGAASACEVSKNKDGKDQGEPVSPSEDEPFSWPGPKTVMLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVAYSQDAYLKGNEAYSGNARNIPEPPPVCYPWLPSTPSATAQPVETCPPDSLPNKQQTSAPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLANRNNPSGPSHRTEEVRYGVNEQASTKAASRTTSPASVPTAHLIHQTTGSRSLEPSGILLKSGNYSGHSEGISSSRSQAVDSPPVSVNHYSANSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSAADYNQVVPTRTTLQVRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPPVSFNNHRTRSWDYIEGQTEATATVNSESQIPDSNGERKQTYKWSGFTEQDDRRGIHERPRQQEMHKPFRGSNLTVAPVVNSDNRRLVGRGVGPVSQFKKIPPDLRPPHSNRNFPTTTGVSLQRGIAQDRSPLVKVRSNSLKVPPPPVSKPSFSQHSLASMKDQRPVNHLHQHSVLSQQTQFRSESTFEHQLETEVSSCLPGTSAKTSPQLSENLGTSDLELPAIPRNGDINLQEAEIQQPDVLDNKESVILREKPQSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHEIAHIPASAVISASTAHVPSIATVPPSLTTSAPLIRRQLSHDQESVGPPSLDGQHSSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKITDSQKSSEDSGSRKGSSSEVFSDAAREGWLQFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTTSDCECLFQAEDRDDMLSWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNSLLSKTEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPAATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTAVQEENTVDSQPVPNIDHLLTNIGRTGVLPGDVSDSATSDSAKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDSVFFKKENTEQSHSEIKEESKRESETSGSKQRVVVAKESNTKKDSGTTKEEKKIPWEEPPPPHSSKRNRSPTLSCRLAMLKEGPRSLLTQKPHCEETGSDSGTLLSTSSQASLLRSSTKKSTSPETKHSEFLSIAGTTTSDYSTTSSTTYLTSLDSSRLSPEVQSVAESKGDEADDERSELVSEGRPVETDSESEFPVFPTTLTSDRLFRGKFQEVARVSRRNSEGSEASCTEGSLTPSLDSRRQQFSSHRLIECDTLSRKKSARFKSDSGSPGDTRTEKETPALAKMFDVMKKGKSTGSLLTPSRSESEKQEATWKTKIADRLKLRPRAPADDMFGVGNQKPTAETAKRKNIKRRHTLGGHRDATEISVLSFWKAHEQSADKESELSAVNRLKPKCSAQDLSISDWLARERVRTSASDLSRGEGLEPQAESPSVLGTPISTHSPPSQQPEARVAATSTLASTSQSPLFTPPQSPDQINRESFQNMSQNASSTANIHPHKQSESPDTKAETPP
What is the function of this protein?
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42.  Downstream partner of ARF1 which may control Golgi apparatus structure and function.  Also required for CTNNA1 recruitment to adherens junctions (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 21, Rho GTPase-activating protein 10, Rho-type GTPase-activating protein 21.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
Protein: DAPF1_NOSS1
Sequence: MAIEFTKYHGLGNDFILIDNRASKTPAITPEKAVEMCDRHFGIGADGVIFALPGENGTDYTMRIFNSDGSEPEMCGNGIRCLAAFLADLEGLSRNKDTYRIHTLAGVITPQLTPDGQIKVDMGLPRLLAGEIPTTLGAADGKVINQPLEVEGQTWEVTCVSMGNPHCITFVEDVAAIPLEIIGPKFEHHPAFPQRTNTEFIQVVSRDYLKMRVWERGAGITLACGTGACASLVAAVLTGRSDRLATVELPGGPLEIEWSEVDQRIYMTGPADRVFTGKL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase 1, DAP epimerase 1, PLP-independent amino acid racemase 1.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y8092_AGRFC
Sequence: MTVAEMSASRSRSLRWFGVAAGLLLLQIVILYAMGRIPICECGYVKLFEPGVNTPGNSQHLADWYTPSHIIHGFLFYWFAWLLFRNKPFSMRLSFAVLIEAAWELLENSPIIIDRYRTATTALGYTGDSILNSAMDTVFMALGFLFAARVPVWLTVVIAIFFEIFTGWLIRDNLTLNVVMLVWPVDVIKEWQNALPQM
What are the official names of this protein?
UPF0314 protein Atu8092.
What is the protein family that this protein belongs to?
Belongs to the UPF0314 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QUEF_XYLFT
Sequence: MNTSHYSVLGHTVPYPKVYDPSLLFPISRAVGRTQIGIGVVLPFVGEDRWHAYELSWLDARGKPCVATATFHVPCDSPYLIESKSLKLYLNSFSAEVFNRAEALRLRIAADLSACAGAAVAVEFGLPPVGSGDKEISLDRLNVDIEDYGPPNPDYLSNVAQNLVEEMVEETLTSTLFKSNCPVTGQPDWASVTVRYFGMPIDHEGLLRYFISFRHHAEFHEQCVERIFQDVLQRCAPQCLAVEARYTRRGGLDINPLRTTSEMAWPLSVFRDPRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRR_LISIN
Sequence: MQKQVVVMDEAAIKRALTRVSYEIIERNKGTKNLALVGIKTRGIYLAERLHKRILEIEGIDVPVGDIDITLYRDDLSFKDDKTREPAVHGTNIPFDINGKKVVLVDDVLYTGRTVRAAMDALMDVGRPAQIHLAVLADRGHRELPIRADYVGKNIPTSGNERVEVRLTDVDHSEDAVIINKNE
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: DXR_ALISL
Sequence: MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPISALALQRQLKSNSIRTDVFSGEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPESIQRKLGRCDLDAHGVSSILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFNTTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFTKIGELSFLEPDYSRYPCLKLAIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRINEQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: YUBI_ECOLI
Sequence: MQYAKPVTLNVEECDRLSFLPYLFGNDFLYAEAYVYALAQKMMPEYQGGFWHFIRLPDGGGYMMPDGDRFHLVNGENWFDRTVSADAAGIILTSLVINRQLWLYHDSGDVGLTQLYRMRDAQLWRHIEFHPECNAIYAALD
What are the official names of this protein?
Putative antirestriction protein YubI.
What is the protein family that this protein belongs to?
Belongs to the antirestriction protein family.
Protein: EF1A2_MUCCL
Sequence: MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYNVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAFTLGFRQLIVAINKMDTTKWSQDRYNEIVKEVSGFIKKIGFNPKSVPFVPISGWHGDNMLDESTNMPWFKGWNKETKAGSKTGKTLLEAIDAIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGTIKAGMVVNFAPAAVTTEVKSVEMHHETLTEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKESASFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFSELIEKIDRRSGKKMEDSPKFVKSGDSAIVKMVPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKAVEKVDKAGKVTKAAAKASKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNRHR_SHEEP
Sequence: MANGDSPDQNENHCSAINSSILLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQRKEKRKKLSKMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLAVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHLADDSGQTEGFSQCVTHCSFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIIFTLTRVLHQDPHKLQLNQSKNNIPQARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMVNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
What is the function of this protein?
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH).  This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RM14_TETPY
Sequence: MIQKETNLKPIDKCGVWSVRAFHLYGGSFRNQSTISNFLKVSVKKTRANNWVPKKTKLKAIIVTLKKELKKIDGSYIKFRTNNVVLLKKRLTPKGKILMGPVSSNLRRKRFLTSFCGSI
What are the official names of this protein?
60S ribosomal protein L14, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Mitochondrion.