PharMolix/UniProtQA huggingface dataset:
Protein: PYRG_LACLM
Sequence: MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQSLDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYASDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGFVFSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Is essential for the synthesis of CTP de novo.  Contrary to other bacterial CTP synthases, the lactococcal enzyme is also able to convert dUTP to dCTP, but this reaction may not play a significant physiological role (PubMed:11500486).  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity).
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NU4LC_JASNU
Sequence: MMLEHILVLSAYLFSIGIYGLITSRNMVRALMCLELIFNSVNINFVTFSGFFDNRQLRGDIFSVFVFAIAAAEAAIGLAIVSSIYRNRKSTRINQSNLLNK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic, NAD(P)H dehydrogenase subunit 4L, NADH-plastoquinone oxidoreductase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS10_MYCTO
Sequence: MAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: TIFA_HUMAN
Sequence: MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMDENES
What is the function of this protein?
Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28877472, PubMed:28222186, PubMed:30111836).  Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852).  TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (PubMed:30111836).
What are the official names of this protein?
TRAF-interacting protein with FHA domain-containing protein A, Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein.
What is the protein family that this protein belongs to?
Belongs to the TIFA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation.
Protein: GPDA_PSYCK
Sequence: MISANDKSTDTNVDSTQAEQKIAEKQNKLLSGIIERATKSSLGRKKLNPSVVESAVAKKMEEIHKNPTKLRLVVLGGGSFGTAMANLAARNGCDTTLWVRNKRTVKAMAKSQMNKKYLPGYKLDDRLKYSHELQAAVKDTDIIFIAVPGLAFRETLKSIAPFISGQSIVSLTKGMEKDTFSLMSDIIKDELPEVNFGVMSGPNLAIEIMKNMPSATVIASESEPLRHAVQAALHSAFFRVFASDDIRGVELGGALKNIYAIAMGMAAAYEVGENTKAMILTRGLAEMSRFGVHAGANPLTFLGLSGVGDLYATCSSELSRNYRIGNMLGRGMTIDAAVKKLGQTAEGVNTIQQVHEKATKEGIYMPITHALYAVIYEDKAALGVALHLMEAGFRSDVEFVMEHDHSNASLTAQMQTANSQSKEDKSKQGNK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_OENOB
Sequence: MNEKTDDIILAFESSADETSAAVVKNGNTILSNVVATQIASHQRFGGIVPEVASRHHLEWINRVTEEALTKAGINDPERQLSAVAATYGPGLVGSLLVGLMAGKTFAMVHHLPFIAVNHLAGHISAANFVKATVYPALAIMVSGGHTELLWMEKENTFQIIGTTLDDAAGEAFDKVGRILGLKYPAGKEIQEMAGHGKAVIKFPIAHTEDDFDFSFSGLKSSVLNYVHHHEQVSEEFNRNDVAASFQKAVVEAITEKSRLAIEKFQPKELLLGGGVAANLALRTAFENLSKEYKIELTEAPIKLSGDNAAMIGAAAYLNYKQRLFAPLDLNVDPSLNFARM
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECG_PYRHO
Sequence: MAKEKTTLPPTGAGLMRFFDEDTRAIKITPKGAIALVLILIIFEILLHVVGPRIFG
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL6_STACT
Sequence: MSRVGKKIIEIPSDVTVDIKGNVITVKGPKGELTRTFDDSMSYKLEDNTLEVVRPSDSQKDRTVHGTTRALINNMVQGVSKGFEKTLELIGVGYRAQLQGSNLVLNVGYSHPVEFKPEDGITFTVEKNTTVKVEGISKELVGATASNIRAVRPPEPYKGKGIRYQGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NTPPA_RHILO
Sequence: MSILQKLVLASGSPRRIELLQQAGIEPDRILPADIDETPLRAEHPRSLAKRLSTEKAEKAFASLKTETGYAPSFVLAADTVVAVGRRILPKAETLDDAANCLGLLSGRSHRVYSGICLITPGGKLRQRLVETRVRFKRLPREEIEAYVASGEWRGKAGGYAVQGLAGSFVVKLVGSYTNIVGLPLYETVALLSGEGFKIHQSWLTARP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_NOVAD
Sequence: MQIVETTNEGLKRAYTVTIPAADIAARVEGEIKKIAPQVRMPGFRPGKVPANLVRKMHGPALHQEALQTTIREAMDKLVADNKLRPAMQPAVSLGEGYDEGKDAELTVELEVLPQIEAPSLDGLKLEKLVVPVTEAEVDEAVARIGQGQKSFTDAKKGAKAKDGDQIIIDFLGKVDGVAFEGGAAEDTPLELGAGRFIPGFEEQLVGVKVGDEKTITVTFPEDYPAENLKGKEATFDITVKAVKNAGEFEANDEFAKMLGLESLEQLKTLLRGQLEQETAGLTRTQMKRALLDQLAAGHDFAVPPSMVEAEFEQIWAQLQQEAQREENPEEALKEIEAEKDDYRKIAERRVRLGLLLSEIGQANGVQVTSQEMEMLIRQAAQQYREQDRQRFVDYVRSEPLAAAQLRAPLYEDKVVDFLFDKAEVTEREVTREELQAAIEAEEGAAAEAKPAKKAPAKKKAAKEEAPAEEAAAEEKPKKAAPKKKAAAADEAPAAEEAPAAKKKAPAKKKAEG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PCAR_PSEPU
Sequence: MSDETLVNDPVNPEPARPASAAMAPPIVASPAKRIQAFTGDPDFMTSLARGLAVIQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKLGYATSDGRTYSLLPKVLTLGHAYLSSTPLAISAQPYLDRISDQLHEAANMATLEGDDILYIARSATVERLISVDLSVGGRLPAYCTSMGRILLAAMDDTSLREYLGRADLKARTSRTLHDPESLFACIQQVRAQGWCVVDQELEQGLRSIAVPIYDASGQVLAALNVSTHVGRVTRSELEQRFLPILLAASRDLCHQLFG
What is the function of this protein?
Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF.  Also required for the chemotactic response to aromatic compounds.
What are the official names of this protein?
Pca regulon regulatory protein.
Protein: ZDHC4_DICDI
Sequence: MSKLNIKGIVKRCDDYGKLVNRYCGPVFVGFATSLITLIAITYFTIIFPATSDFSNLFFIFNFFCDLSISLFLTYGIYFNYIKAIITKPGYPNLNSTLINNINSNINNSNNNKDKDKILIIDNVKWSYCKKCSKAKPPRCHHCSVCDKCVLKMDHHCPWIGGCVGFYNYRYFFLFLSYLWVSVCYVLAHSLPLLFGGYLYSKKYTEIDRLLVIISSIGSFITFVAVGSFGGFHAYLIGSGQTSIENLYPPKKRPNYSLTSIKDNFQIVLGKGDYWFSGLLPINYTPIGNGCDFKLNISNEDNNKNNENNENNENNEIDNHNNNNNNNNNNNNNEKEDNINENDNLISYDTDEYNRHKK
What are the official names of this protein?
Putative ZDHHC-type palmitoyltransferase 4, Zinc finger DHHC domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATPI_ARATH
Sequence: MNVLSCSINTLIKEGLYEISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAVLAIRNPQTIPTDGQNFFEFVLEFIRDVSKTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIQLPQGELAAPTNDINTTVALALLTSVAYFYAGLSKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LACD_LISMF
Sequence: MVQITKGKFDGLQRLSNEKGVIAALAIDQRGSLKKMIQQAKGTENKKDVEDFKQLVSEELTPYASAILLDLEYGTPAIKARHEGSGLLTSYEKTGYDATTPGKLPDLIEDLSALRIKENGGDAVKILVYYDPDEPAEINEIKYAFLERIGAECRAVDIPFFLEPITYDATVTDSGSLEYAKLKPAKVKASIKEFSKPRYGVDVLKLEVPVNFKYVEGFAEGEVAYTQDEAARHFEECSDLSPLPFIYLSAGVTSEMFHKTIQFANQHNVQYSGVLCGRATWADGIEVYGKQGDDALREWLRTQGKENITSLDKLLDEGAVPWWTKYGSFEDVHVVEKQ
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: CURS1_ASPTE
Sequence: MPSAQHSVGDVPIAVVGLSCRFPGDASTPSKFWDMLKNGKDAYSPTSTRWNSDAFYHPGDGRLNSLPTKGGHFLKEDPYVFDAAFFNITAAEAIALDPKQRIAMEVTYEAFENAGMSLQQISGSQTACYIGSGPSDYRGAVERDFLHNPKYHLLGTGDEMISNRISHFLDIHGPSATVQTACSSSLMATHLACQSLRSGESEMAITGGISLMLTPDFTTHLNNLTFLNPEGLSKAFDESAGGYGRGEGCGIIILKRLADAIQDGDDIRAVIRGTGANSDGFTQGVTMPSFEAQAALIRQVYSSNGLDYSTQYVEAHGTGTKAGDPIETRAIYSTIGKGSPKPRKLFVGSVKPNIGHLESAAGVSGIIKGILSMEHNLIPPNLHFTKANPAIPFDEWNMAVPTKLTPWPVAATKRMSVSGFGMGGTNGHVVLESFDSTRSTNGSGYSGGFSTFEKTRTKKRLFVFSSHDQAGFKRNANALAEHLDTVGSVASSSDFMANLAHTLSGARSSLSWRATCIAENKIELRDYLTTKPGDGASRDATNATRAPRIGFVFTGQGAQWARMGVEMLDRPVFRDSVAQSTHYLQAMGCVWDPVAELKKTQADSRLSQPEISQPICSVLQIALVDELRSWGVTPSKVVGHSSGEIAAAYSIGALSHRDAIAAAYFRGVATVRLRADAPDLKGGMMAVGCSRDEAEELIEQSKLDGTAAVACVNSPSSVTLSGDVDTLEQLRAICDEHKVFVRRLKVEMAYHSRHMNRVSGTYAEFIADLQPIPREYNENEDDDSIQTMLSSVTGQEVAPELLGPYYWVRNLVSPVLFSDAVKEMVAPDEAEGDNTVDLLIEIGPHGALGGPVEQILGHHGVKHITYKSMLTRGRNALETSLELASELFLKGVPIDISQVNSDLNPRRLTDLPPYQWNHSKVFRHETRIQRELVMRQFPSKSIIGAQVPMMDESQHVWRNFLRLSDEPWIRGHKVGSTVLFPAAGLIGMALEAAQQLVEPSKTARSLRLRDISFFAAMALSEDVPTEVIMHLRPHLLATSGSTPAAWWEFTISSCAGIDNLRDNCRGLITIDYAETTSEQMASEDASLEASRIAHYHRVREESSYTYSKEDFYSQFEKIAWNYGEAFRGVEKVYLGDGQATYDVKLVDIGETASKGQLDRPFLIHAGALDSILQGCLGSTYRNGRFDMDKPVLPTFIGQMEISLDIPGDAGYVLPAVCESKRHGFKELSSNIYAFDSAVSKVNLSVVDYRVSELENDSGEQDSQQLEVDPAEITSEVRWNYALEVLEPEEIKKVVLAVAAEDRVVELIRLYLHNNPAATVIELVPDYEALERATMSLLPPGTILPSHIKYAVAATGSKSENQVDIENVIGTPFDLGDLDDTLPTDIAAADLLVIPQSVNNHKDLGVLLTRLTSFGKPDASLVLAVNSSVNVSNSMLESKGFRRVFDLENSVALYKSRQSGHTNGHTNGHTNGTSTRSELFIIEPLATSSRINSFSGALQVTLREHGYPVFVTNWTEISARPAADLEGNTFISLLELEQPLLDALSEPDFYSVRKLLLNSDRLLWITAGDNPSMGVVDGIRRTMRSEVAGLKFQVLHLSSLDTALQCGPALAGRIMTTDTKDDEFQERDGMLQVARIFNSPEGNEGVRRCLEDSVRVERLGEQERALRLTIMKPGLMDTLTFIEDDRMTGPLGATEIEVDVKATGVNFKDIMAAMGLVEVSLIGQEASGIVTATGSTAASRFKPGDRVTLLWEGMHVTKLRIDHRLAVHIPDSMSFEEAAALPMVHTTAYHALVNVAKLRPGQSVLIHAAAGGVGQAALQLATHLGLVAYVTVGSEDKRRLLMEKYNVPEAHIFHSRDTSFAKAIKRVTGGRGVDCVLNSLSGELLRVSWTCLAPFGTFVEIGLRDITNNMRLDMRPFSRSTTFAFINIANFFDPEGLDALGQILSDAFALVHKGVLGTAYPLTVYPVSELETAFRTMQQGKHRGKLVLSFGDNAQAPVLCKARDSLRLSPKSTYLFIGGLGGLGRSLAREFVACGARHIAFISRSGDSSAEAKATVQALTTLGANVKAYRADVSEEAAFLSAMQQCATDLPPIAGVVQMAMLLRDTLFEKISYTDWTQPMRPKIQGTLNLHNYFSATRPLDFFVICSSISGIFGYPGQTQYAAANTFQDALARHRRNQGLKGVAVDLGIMRDVGILAEQGTTGKLADWEAILGIREKPFHALMKSVINSEWKGAVPPPAQLCTGLGTADIMARFGLERPEHFSDPRFGPLNVLSIESSSSLSTDQDTASSPSTRLAAATTLDEAVVIITDALVHKMAEILQMPLSEVDPGRPMYRYGVDSLVALEVRNWITRELQANMALLEILAAEPMRVFAGKIAEKSKLVAGRKG
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of 10,11-dehydrocurvularin, a prevalent fungal phytotoxin with heat shock response and immune-modulatory activities (PubMed:23335766, PubMed:26493380).  The highly reducing polyketide synthase curS1 is responsible for biosynthesis up to the tetraketide stage (PubMed:23335766).  The non-reducing polyketide synthase curS2 then conducts four additional chain extension cycles, producing the unreduced part of the nascent octaketide from C-1 to C-8 in 10,11-dehydrocurvularin (PubMed:23335766).
What are the official names of this protein?
Highly reducing polyketide synthase curS1, Dehydrocurvularin biosynthesis protein 1.
Protein: CD4_SAISC
Sequence: MNGGIPFRHLLLVLQLALLPAVTHGKTVVLGKKGEVVELPCETSLKKNVPFHWKTSDQIKILGVQNYFVTRGQSKLTDRIDSKKSSWDRGSFPLLIKDARIEDSETYICEVESKKEEVELQVFGLTANPDTHLLQGQSLTLTLESPPGSSPSVECTSPRGKRIRGRKTLSVSQLGIPDSGTWKCTVFQHLELVFEINIVVLAFQQASSTVYKKEGEQVEFSFPLAFAAETLTGSGELCWQAERASSSKSWITFNLTKQEVYVKLVTQDPKLRMGKKLPLHLTLAQALPQYAGSGNFTLALKGKTGKLHQEVNLVVMRVTQLQNNLTCEVWGPTSPKLMLSLKLENQEAKVSKREKAVWVLNPEPGAWQCLLSDSGQVLLESKFEALPTRSPPVQPMVLIVLGGVAGLLAFTGLGIFLCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Protein: KDSB_BURCH
Sequence: MTHPPPFIAVIPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLVASDAQSVLDAARDHGFEAVLTRADHPSGTDRLAEVAAAFGWRDDTVVVNVQGDEPLIDPVLVRDVASHLAAHPACAIATAAHPIHDAADVFNPNVVKVALDAQSVALYFSRAPIPWSRDAYQPHWPDVAAMPAPAFPVYRHIGLYAYRARFLRTYPSLAQAPIEQAEQLEQLRALWHGERIAVLITESAPEAGIDTPADLARVQALFQPGSK
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_KOCRD
Sequence: MRIVLQVVSRASVTVAEETVGEIEGPGLLALVGLTHTDTPETVSRLAGKVAGLRILPGETSCADGPSPVLAVSQFTLYGDVRKGRRPSWSRAAPGQQSEPLFEAFVAALRERGIPVRTGRFGAHMEVSLVNDGPVTVLVDSDELDRPRRG
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGIDB_PSEPU
Sequence: MAKVFAIANQKGGVGKTTTCINLAASLAATKRRVLLIDLDPQGNATMGSGVDKHELEHSVYDLLIGECDLAQAMHYSEHGGFQLLPANRDLTAAEVVLLEMQVKESRLRNALAPIRDNYDYILIDCPPSLSMLTLNALVASDGVIIPMQCEYYALEGLSDLVDNIKRIAARLNPELKIEGLLRTMYDPRLSLNNDVSAQLKEHFGPQLYDTVIPRNIRLAEAPSFGMPALAYDKQSRGALAYLALAGELVRRQRRPSRTAQTT
What are the official names of this protein?
Uncharacterized protein in gidB 3'region.
What is the protein family that this protein belongs to?
To B.subtilis soj.
Protein: CH10_LISMC
Sequence: MLKPLGDRVVIEVLEAEEKTASGIVLPDSAKEKPQSGKIVAVGSGRVLDNGTKEPLEVAEGDTVIFAKYSGTEVTYEGTDYLILRESDILAITK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFTR_RUEST
Sequence: MTLSADLLLHAYANGVFPMAESRDDPEVFWVDPKRRGILPLDGFRISRSLAKRLRRDDYSISVNRDFAGVVQGCADREETWINGEIFDRYQELHHDGFAHSLEVWMDDALVGGVYGVSLGGAFFGESMFSRRRDASKIALAYLVDRLNAGGYILCDTQFITPHLASLGGREISRAAYRRRLAEALDQPGDFISPALPSPQVLLQRRTQTS
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTD_YEAST
Sequence: MLIGVSGTKFCGCEDVINMLVDHFHFELLNHLDNPEEILDYATKNYTKNSVIFLEKLSLLEKLEKRPFFVHLSIDAPVTTRVALYRKTTQAESLSLEQIIQAIDQHDFQPEGIKLREKSHLRFKIVNEDRRGRRQSLINNITTQLKILDDKEKQMAPLMRPSWDSYFMKLATLAASRSNCMKRRVGCVIVRECRVIATGYNGTPRHLTNCFNGGCPRCNDGDSRNLHTCLCLHAEENALLEAGRDRVGQNATLYCDTCPCLTCSVKIVQTGISEVVYSQSYRMDEESFKVLKNAGITVRQFSFTEEPRIVMI
What is the function of this protein?
Catalyzes the hydrolytic deamination of dCMP to yield dUMP, the nucleotide substrate for thymidylate synthetase.
What are the official names of this protein?
Deoxycytidylate deaminase, dCMP deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: GATB_CORGB
Sequence: MTAAFYDLMDFDEVLEKYDPVMGLEVHVELGTETKMFSASSAHFGAEPNSNVDPVSLGLPGALPVVNAKGVEWAIKIGLALNCSIAESSRFARKNYFYPDQPKNYQISQYDEPIAYDGYLDVVLEDGTEWRVEIERAHMEEDTGKLTHLGGTSGRIHGATASLVDCNRAGIPLIEVVTKPIEGAGARAPEIAKAYVSALRDLVKALGVSDGRLDQGSMRVDANLSLRPIGQEEFGTRTETKNINSLKSVEQAITFEMQRQAQVLDDGGVIDQETRHYQEADGSTSKGRPKETAEDYRYFNDPDLPPVIAPREWVEEIRATLPELPWVRRARIQEEWKLSDAEMRDLINANALDLIIETVEAGTTPDEARAWWVSYISQKANESGVELDALGVAPAHVARVVALVSEGKLTNKLARQAIDGVIAGEGDVDAVVAARGLEVVRDDGAIEKAVDEALAANPDIVEKYRAGNTKVTGAIVGAVMKATRGKADPAQVNQLIAKKLA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.