PharMolix/UniProtQA huggingface dataset:
Protein: E1B55_ADECT
Sequence: MEQNADMEPDRQVNQRPPRFRARGAGVRGRGRVRRSAFSRGQRRPIIRVDDLQLPDPLYVMQALQRDHTLEMPRGQVDFSWIEAEERRVGPTDEWYFEAVKTYKAKPGDDLQTIIKNYAKISLECGAVYEINSKIRVTGACYIIGNCAVLRPNLPAGEAMFEVLNVDFIPSIGFMERIVFSNVIFDCRTTATVVCCISERNTLFHNCVFSGPHMLCLDLRAGAEVRGCHFVGAVCALRSKGLYSIRVKNSIFEKCAFGVVTGSKASISHCMFKDCTCSIMLGGQGTIAHSQFIVTTSAEAPMNLQLCTCEGNGSHVVPLGNIHFASHREASWPTFYANTLVRVRLYMGRRRGVFHPKQSTLSMCVIAAPRGVVQRIYLFGVYDATCAIMQLGEAGNAASERLCTCGFRHSTPSLRATYVTDTRIDRELNSQDTAEFFSSDEDNF
What is the function of this protein?
Plays a major role to prevent cellular inhibition of viral genome replication.  Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.  This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM.  Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.  E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain.  E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
What are the official names of this protein?
E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 55 kDa protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53.
Protein: THIG_NITOC
Sequence: MSTLDTPLVVAGKTYHSRLMVGTGKYQDLEETQNAIQASGAEIVTIAIRRSNIGQNPGEPNLLDVISPHCYTLLPNTAGCYNAKEAVRTCRLARELLDGHSLVKLEVLGDEKTLFPDLVETYQAAEVLIKEDFQVMVYTNDDPIAAKRLEEMGCVAVMPLAAPIGSGLGIRNPYNILEIVQNATVPILVDAGVGTASDAAVAMELGCDGVLMNTAIAGAQNPILMASAMKKAVEAGRDAYLAGRIPRRRYASASSPLEGTFF
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_RHIL3
Sequence: MPKRILQGVVVGDKNEKTVVVRVERRFAHPLLQKTVRRSKKYKAHDENNQYKIGDTVSIEECAPISKDKRWTVISAQGK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PIT_BUCAI
Sequence: MLHLFSYSDLNHSLLVFLALFFVLFYEAINGFHDTANAVSTLIYTRAMSAHVAVIMSGIFNFLGVLLGGLTVAYTIVHLLPNDLLLNATSKNALAMVFSMLLAAIIWNLSTWYFCLPASSSHSLIGAIIGIGLTNAFVTDSSLVDAFNIPKMTSVFLSLVFSPIIGLIIAGSLIFLLRYYLNNNKIFYRIHMTPLERKEKDGKKIPPFLIRMALILSSIGVSYAHGANDGQKGIGLIMLVLIGIVPSSFLVNLNTNKYEINCTKHTLNHLEKYFLEKNIKKSNIIKNKEEINNLVVRSQSYNSIKNIKNTKLLLKNISNYNDLSIKKRFQLRHYLLCISDSIDKKVNSSDICSKDKRFLIHSKKVILKTIEYAPMWIILIVALSLSIGTMIGWKRIVVTIGEKIGKKRMTYAQAMSAQITASFSIGIASYTGIPVSTTHILSSSVAGTMLIDGDGIQTKTIKNIALAWILTLPVSMLLSSFLYWIALFLI
What is the function of this protein?
Low-affinity inorganic phosphate transporter.
What are the official names of this protein?
Low-affinity inorganic phosphate transporter.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIHI_PECCP
Sequence: MNRPVKGAADKAGKPKVKRKTREELEREARERKKDKKHRGHVAGSRTQEKASTDQRSGQRKAADPRIGSKKPVPLGVLDSAVAKPKPKSKPSAPVENVVAAKPTMSPEEELEMLENDSRLDALLDRLDSGETLSAKDQSWVDETLDRIDILMEELGIELGDDDEEEPQEDMLQLLKRNNPKDAF
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: EIF3K_ARATH
Sequence: MGVEIQSPQEQSSYTVEQLVALNPFNPEILPDLENYVNVTSQTYSLEVNLCLLRLYQFEPERMNTHIVARILVKALMAMPTPDFSLCLFLIPERVQMEEQFKSLIVLSHYLETGRFQQFWDEAAKNRHILEAVPGFEQAIQAYASHLLSLSYQKVPRSVLAEAVNMDGASLDKFIEQQVTNSGWIVEKEGGSIVLPQNEFNHPELKKNTGENVPLEHIARIFPILG
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARMC8_MOUSE
Sequence: MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSPSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDSCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETETMMDRIVTGSSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDMNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHSIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLTWNEEEGSQERQDKLRDMGIVDILHKLSQSADSNLCDKAKTALQQYLA
What is the function of this protein?
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
What are the official names of this protein?
Armadillo repeat-containing protein 8.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: 3MGH_BACC0
Sequence: MQAPPSFYEGDTLEVAKKLLGQKLVHIVNGIKRSGIIVEVEAYKGPDDKAAHSYGGRRTDRTEVMFGAPGHAYVYLIYGMYHCFNVITAPVGTPQGVLIRALEPVDGIEEIKLARYNKTDITKAQYKNLTNGPGKLCRALGITLEERGVSLQSDTLHIELVPEEKHISSQYKITAGPRINIDYAEEAVHYPWRFYYEGHPFVSKK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: YR02_CAEEL
Sequence: MKPGFKDLRAVGYQTDVPYVSLSNYCWSFNCPKPGAEVEFLNMTFQLMNSTATIVQIDADIEQSIDMVSNGSADITLVSARQTLDRMKKVDFTTPIGFVYYGYLVREIPELAVADYIMRLFDYDTLAILISFGLIIGALLYLYTWIFGLRVRSLLDWMFISCSGIIHQFMFRISSPICALVLIGFWLLCCLVIITYYEAKLKSFLLLSHHRGTIFNTLDGVLEAAEHKGWTLVIQERGYTPYLYCNPSQCARLDRLKSRINFIGADDDANLLLGQDKHVGFSALASDLAETDITYFDYHSKILFVRDKIMAPEYLAYAVNKNVKGLREKFNRAVAYTKSGYGTVRSRYIASFPSYNSVTSQSQTITVLQTSHFIQLYKFCFIFYGIAIIVFILEIIFHRMTKNFTFFGHSYNYHLSGFEWRFARPKWIHFPRRNTVILPLSKSYSPDNERRVTVC
What are the official names of this protein?
Uncharacterized protein T25E4.2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THAP1_HUMAN
Sequence: MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLLEPQEQLPPPPLPPPVSQVDAAIGLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDDVSERGYVILPNDYFEIVEVPA
What is the function of this protein?
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression.  Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1.  Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.  May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
What are the official names of this protein?
THAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the THAP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, PML body.
Protein: PUR9_BARBK
Sequence: MVVVSQNYPTPDLHRVRRALLSVFDKTGLVEFAQELHAYGIELISTGGTSESLIAAGLPVKDVSEVTGFPQIMDGRVKTLHPLIHGGLLGVRDDPSHKAAMEKHGICGIDLVVVNLYPFEKTWQSGADSQTIIENIDIGGPAMIRAAAKNHAYTGVVTAVSDYDVVLAELKQHNGCLSFSLRRQLAARAYEHTAAYDAAIAAWFAQDLEVEMPSWQNFSGHFESMMRYGENPHQRAAFYRTRDTRFGVATAKVLQGKELSYNNMNDADAAFELVAEFDPQRTAAVALIKHANPCGVAEGQSLKEAYLKALMCDSVSAFGGIVALNQPLDEECAAEIVKLFTEVIIAPDATEAACNIIAQKKNLRLLITGGVPDPRCGGLTVKTLAGGVLVQSRDNAVVDDFDLQIVTKRAPSQDEMRDLQFAFRVVKHVKSNAIVYAKNSATVGIGAGQMSRLDSARIAVHKAEDNAKRMGLTESLTRGSVVASDAFFPFADGLISAAEAGVTAVIQPGGSIRDQEVIEAADARGLAMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SYA_FRATO
Sequence: MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSRAVTVQKCLRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKLPVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNFWSMGDTGPCGPCTEIFYDHGEDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQNVHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVLRRIIRRAIRHGNKVGAKEIFFYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKTIENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTADMAREKGLKVDEQAFLAQMQIQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAVVVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTARVSDKPRLATAANHSATHLLYKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIEQIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYGDIVRVISMGDFSIELCGGTHVAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLIDKIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDDYKSKNTKVIAVLTTTNADKVQFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQGGGNNSANIDQALSQVEKFILNNIKE
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRSA_ECOSE
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITGWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: ATPF_ENTHA
Sequence: MLNQLAIAEVGNPMLGNIIVVSGSFLILMFLLKHFAWGPISDILKKREDKIANDLDSAEKSRINSAKMEQEREQQLLASRSDAADIIKNAKESGELSRQNILKETQEEVARLKSKAQTDIMLERDTALNSVKDDVADLSLQIAAKILNKELSPEMHESLINQYIEGLGSSNETR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RLME_PSEPK
Sequence: MVQRSKSSANWLREHFNDPFVKQAQKDGYRSRASYKLLEIQEKDRLIRPGMSVIDLGAAPGGWSQVTSRLIGGQGRLIASDILEMDSIADVTFIQGDFTHDEVLQRILEAVGDSHVDLVISDMAPNMSGTPAVDIPRAMFLCELALDLATRVLKPGGDFLIKIFQGEGFDVYLKDVRSKFDKVQMRKPSSSRDRSREQYLLGRGFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_SYNP6
Sequence: MLDASISPVVLVILDGWGYRNATEGNAIRTAETPIMDALWEAYPSTLIHTSGKDVGLPDGQMGNSEVGHLNLGAGRIVPQELVRITDAVEDGSILENPALLQACSAVRQHGSKLHLIGLCSDGGVHAHLDHLGGLLKLAAAQGIQDVYIHAITDGRDTNPTEGVNCITKIERLIATAGVGQIVTICGRYFAMDRDRRWDRVRKAYELLTIDGEGCGQTATEVLQETYAKGVSDEFVEPTRLAPGAIAPGDGVIFFNFRPDRARQLTYAFVEAEFEGFERDLIQPLTFVTFTQYDANLNVPVAFEPQNLTNILGEVVANHGLRQFRTAETEKYPHVTYFFNGGIEEPFPGEDRELIPSPMVATYDRAPKMSAQAVTDAAIAAIDKGIYSLVVINYANPDMVGHTGKMGATVEAIETVDRCLGRLVSAINRAGGTALITADHGNAEYMWDENGEPWTAHTTNLVPFIVVEGERRKLPGFGTEIPLREDGRLSDIAPTILQLLGLPQPVEMTGRSMIEPAAYEVKQGRTPVKVGV
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RL21_SALPK
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETIEFAEVLMIANGEEVKIGIPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CECE1_CANAL
Sequence: MKFSKIACATVFALSSQAAIIHHAPEFNMKRDVAPAAPAAPADQAPTVPAPQEFNTAITKRSIIGIIMGILGNIPQVIQIIMSIVKAFKGNKREDIDSVVAGIIADMPFVVRAVDTAMTSVASTKRDGANDDVANAVVRLPEIVARVATGVQQSIENAKRDGVPDVGLNLVANAPRLISNVFDGVSETVQQAKRDGLEDFLDELLQRLPQLITRSAESALKDSQPVKRDAGSVALSNLIKKSIETVGIENAAQIVSERDISSLIEEYFGKA
What is the function of this protein?
Acts as a cytolytic peptide toxin that directly damages host epithelial membranes, triggers a danger response signaling pathway and activates epithelial immunity (PubMed:27027296, PubMed:35073742).  Probably acts similarly to cationic antimicrobial peptide toxins, inducing lesions after binding to target cell membranes and causing an inward current associated with calcium influx (PubMed:27027296).
What are the official names of this protein?
Extent of cell elongation protein 1.
Protein: MNTP_PSEU2
Sequence: MNPISLLFLALAMSTDAFAAALGKGASLHKPRFLEALRTGLIFGAIETITPVIGWGIGQVAARFAESWDHWIAFTLLLVLGLHMIYNGIKHDDDEEQEKPGQHSFWILAVTAFATSIDALAVGVGLAFVDVNIVVAALAIGLATTVMVTIGVMLGRVLGTMVGKRAEIIGGIVLIVVGATILYEHLSAAQ
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS20_ALCBS
Sequence: MANSPQARKRARQAENRRQHNAAMRSMVRTYLKKVNAAIASGDQGSAQEAYNQAVSVLDKATRKGKFHPNKAARHKSRLNTKIKAMAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RSMH_MOOTA
Sequence: MPFTHQPVLLTEVLHLLDPQPGEFFVDATVGGGGHSRAILPRLLPGGHLLGLDRDAEAVAAARERLAAFGANVEIVQANFRDLAAILEARGIPGVDGLLFDLGVSSYQLDNPERGFSYQVDAPLDMRMGQDQELTAAEVVNNWPEEKLTRVIWQYGEERWAPRIAAFIVASRRQRPITTTGQLVAIIKEAIPAGARRSGHHPAKRTFQALRIAINGELDALRAALEQLDSILKPGGRVGVISFHSLEDRIVKEAFRSLSGRCTCPPGLPVCTCGRREVLVPVTRKPVIPTAAEIVANPRARSAKLRVARRVLKDKDGE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_GRAFK
Sequence: MSDQKINILAIESSCDDTAAAVLCNGKILSNIVATQKVHEQYGGVVPELASRAHQQNIVPVIHQALAKANIDKKDVSAIAFTRGPGLMGSLLVGTSFAKSLSMGLNIPLIEINHMQAHILAHFIEEDDFEKPTFPFLAMTISGGHTQIVKVTDYFKMEVIGETIDDAVGEAFDKSAKILGLPYPGGPLIDKYAQEGDPKAFKFPKPKVDGLNFSFSGFKTAVLYFVQRETKNDPEFVEKNLKDICASIQYTIIGILIDKLKKAVKETGITQVAIAGGVSANSGIRQALKDAEQKWGWKCFVPKFEYTTDNAAMIGIAGYHKYLKKDFADFSVTAQSRYKF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_AZOVD
Sequence: MSEYSLFTSESVSEGHPDKIADQISDAVLDAIIAEDKHARVACETLVKTGVAIVAGEITTSAWIDLEELVRKVIVDIGYDSSDVGYDGHTCGIINIIGKQSVDINQGVDRAKPEDQGAGDQGLMFGYASDETEVLMPAPICFSHRLVERQTEARKSGLLPWLRPDAKSQVTCRYENGKVVGIDAVVLSTQHNPEITQADLHEAVMELIIKHTLPAELLHKDTQFHINPTGKFVIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISINTFGTGKIGDDRIVQLVREHFDLRPYAITHMLDLLHPMYRPTAAYGHFGRTPVEMTVGNDSFTAFTWERTDKAEALRSDAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_RHIWR
Sequence: MASIEKLPMLAEGQKMLTEELARLKAERPLIIDAIEEARAHGDLSENAEYHAAKERQGQIEASIADIEDRLSRAQVIDPSMLSGDKIVFGATVTLLDDDEKPVRYQIVGQTEADAKTGKISYNSPLGRALIGKKVDDEVEVTVPSGDRFYLVSKIEFI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: PUR9_BUCAT
Sequence: MPSNNLIKNALISVSDKKNIVEVAEKLIINKINLFSTGGTAQILKKNNIPVTEISDYTKFPEIMDGRVKTLHPKIMGGILGQKQKDQEIMKLYNICPIDIVIVNFYPFEKIKNIKKNDIDNVVNNIDIGGPTLVRASAKNYKNVIVIVDLDDFQSTIDSINNNTMNMEKRFNLASKAFEYTSYYEQIISQYFIEQNSLYKKTNNSLFPNEINFSFIKKQDLRYGENYHQKSSFYIEKNMCDSGTISTACQIQGKTLSYNNISDSDIALECVKQFTKPACVIVKHGNPCSVAVSHNILESYLSAYNSDPISAFGGIISFNCKLDEKTAQTIINQQFVEVIIIPEISKKAVKILQKKQNIRVLVTGKLQNNTVGLDLKKITNGLLVQEYDSHNIDYNSWSFVTKRSPTKKELKDSIFCWQVAKFVKSNAIVYGSDEITIGIGAGQMSRIYSTKLANIKVKDQGKNIIGATMASDAFFPFRDGIDEAASVGISSIIQPGGSIRDEEIIRAADEHNITMIFTKKRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SUCC_PECAS
Sequence: MNLHEYQAKQLFARYGLPAPTGYACTTPREAEEAASKIGSGPWVVKCQVHAGGRGKAGGVKVVSNKEDIRAFAENWLGKKLVTYQTDAQGQPVHQILVEAATDIDKELYLGAVVDRGTRRVVFMASTEGGVEIEKVAEETPELIHKAAIDPLVGPQPYQGRELAFKLGLSGKQVAQFTKIFMGLATLFLERDLALVEINPLVITKQGDLICLDGKLGADGNALFRQPELREMRDPSQEDSREAHAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGSPANFLDVGGGATKERVTEAFKIILSDDKVKAVFVNIFGGIVRCDLIADGIIGAVAEVGVSVPVVVRLEGNNAELGAKKLADSGLNIIAATSLTGAAQQVVAAAGDK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: GRPE_CANGA
Sequence: MRAFSNVSRISRVSRVSRVALAAPARTVPLMNRNAMSMMRFYSEDAKASEKAGEKAEEKAEEQNLSAEEQKLKDLQEQLDKKTKEAAELKDRLLRSVADFRNLQEVTKKDVEKAKSYALQKFAKDLLESVDNFGHALGAFKEEDLEKSKEISDLYTGVKMTRDVFEKTLKKYGIEKLDPLGERFDPNKHEATFELAQPDKEPGTVFHVQQLGYTLNERVIRPAKVGVVKED
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins (By similarity).
What are the official names of this protein?
GrpE protein homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GCH1_ECOUT
Sequence: MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRHEFLRAVRHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: YR406_MIMIV
Sequence: MDSKPYRYISKAINLDLYNELVSEIKPKRELMTVTYSDAKIPERRETAWQTETDISAEYSGKTMDPVPFTPTVHMLKKKIEEIIGVEFDSALIFHYIDGKDSMGYHYDTIGVGRGNHIAGVTFGSSRCLGVRNNETNEKEFFNLGNGDIFYMFDDCQKKYKHAILESKEENPGPRIAITFRQMGPNLSQKN
What are the official names of this protein?
Uncharacterized protein R406.
Protein: YL466_YEAST
Sequence: MSLRPCLTPSSMQYSDIYIPTHSLTSTSTLAVIPYPAF
What are the official names of this protein?
Putative uncharacterized protein YLR466C-B.
Protein: RISB_CAMJ8
Sequence: MNIIEGKLNLDSNTKIAIINARFNHIITDRLVEGAKDAFLRHGGKEENLSLILVPGAFELPYALKKAIESKKFDAICCVGAVIRGSTPHFDYVSAETTKGIANVSLNHNIPVSFGVLTTDTIEQAIERAGSKAGNKGFEAMTTVIEMLNLSKEL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.