PharMolix/UniProtQA huggingface dataset:
Protein: RL52_ARATH
Sequence: MVFVKSSKSNAYFKRYQVKFRRRRDGKTDYRARIRLINQDKNKYNTPKYRFVVRFTNKDIVAQIVSASIAGDIVKASAYAHELPQYGLTVGLTNYAAAYCTGLLLARRVLKMLEMDDEYEGNVEATGEDFSVEPTDSRRPFRALLDVGLIRTTTGNRVFGALKGALDGGLDIPHSDKRFAGFHKENKQLDAEIHRNYIYGGHVSNYMKLLGEDEPEKLQTHFSAYIKKGVEAESIEEMYKKVHAAIRAEPNHKKTEKSAPKEHKRYNLKKLTYEERKNKLIERVKALNGAGGDDDDEDDEE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  Seems involved in the regulation of cell proliferation (PubMed:19392710).  Essential in leaf polarity establishment, probably having a role for translation in leaf dorsoventral patterning to specify leaf adaxial identity (PubMed:18305007).
What are the official names of this protein?
60S ribosomal protein L5-2, Ribosomal protein L5 B, Protein OLIGOCELLULA 7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RL36_PSYWF
Sequence: MQVLSSLKSAKNRHPDCQVVRRRGRVFVINKTDGRFKAVQGKKKK
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: PRMA_ALIF1
Sequence: MPWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILALYDAEADMDFVITQLKASRLLEEGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWREIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEGKTVVDFGCGSGILAIAAIKLGAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLRELSGIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_PSEF5
Sequence: MSAQVIAIDAMGGDFGPRSIVQASIACLSATPSLHLTLVGQPSLLEELISGQTAVDRARLTITPASEVITMDEKPSQALRGKPDSSMRVALELLRDEKVQACVSAGNTGALMALSRYVLKTLPGIDRPAMVAAIPTQRGYCQLLDLGANVDCSAEHLLQFAVMGSVAAETLGIVRPRVALLNIGTEDIKGNQQVKLAASLLQQARGLNYIGFVEGDGLYRGEADVVVCDGFVGNILLKSSEGLATMIAARIEALFRQNLLSRAVGALALPLMRRLQADLAPARHNGASFLGLQGIVVKSHGSAGVQGFQSAIQRALIEIQEDLPRRLHGRLEDLLL
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ATPA_ALKCK
Sequence: MASIKATEISSLIKQQIDQFETTVNVQDVGTVIRVGDGIAFAHGLDNVMAGELLEFSTGVMGMAQNLEEDSVGIIILGPYTDIREGDEVKRTGRIMEVPVGSELLGRVVNPLGQPLDGLGPVHTSKTRPIESPAPGVMARKSVHEPLQTGIKSIDSMIPIGRGQRELIIGDRQTGKTAIAIDTIINQKDQDMICVYVAIGQKESTVSGVVETLRQRGALEYTIVVSASASDPAPLLFLAPYTGVSMAEEFMYNGKHVLVIYDDLSKQAAAYREMSLLLRRPPGREAFPGDVFYLHSRLLERAAKLNDDLGGGSITALPFIETQAGDVSAYIPTNVISITDGQVFLQSDLFHSGVRPAVNPGISVSRVGGSAQIKAMKKVAGTLRLDLAAYRELEAFAQFGSDLDAATQARLNRGERTVELLKQDLHQPLPVEKQVAIIYALTKGYLDDVPVADCRRFESELFTYLESNNNELLEHIRTTGNLPEESDLKAAIEAFKKGFVASNE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FUR_VIBCH
Sequence: MSDNNQALKDAGLKVTLPRLKILEVLQQPECQHISAEELYKKLIDLGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFELSTQHHHDHLVCLDCGEVIEFSDDVIEQRQKEIAAKYNVQLTNHSLYLYGKCGSDGSCKDNPNAHKPKK
What is the function of this protein?
Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon.
What are the official names of this protein?
Ferric uptake regulation protein, Ferric uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL331_STRPM
Sequence: MRVKINLECSECGSNNYLTSKNKSSHPEKIKVPKYCPKERKVTLHVET
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RL3R2_HUMAN
Sequence: MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG
What is the function of this protein?
High affinity receptor for INSL5.  Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin.  Binding of the ligand inhibit cAMP accumulation.
What are the official names of this protein?
Relaxin-3 receptor 2, RLN3 receptor 2, G-protein coupled receptor 100, G-protein coupled receptor GPCR142, Insulin-like peptide INSL5 receptor, Relaxin family peptide receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRI_SHIB3
Sequence: MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: PRMA_STAEQ
Sequence: MNWMELSIVVNHEVEYDVTEILESYGSNGVVIEDSNILEEQPVDKFGEIYDLNPEDYPEKGVRLKAYFNEFTYNENLKSNINYEILSLQQIDKTIYDYQEKLIAEVDWENEWKNYFHPFRASKQFTIVPSWESYVKENDNELCIELDPGMAFGTGDHPTTSMCLKAIETFVKPTDSVIDVGTGSGILSIASHLLGVQRIKALDIDEMAVNVAKENFKKNHCDDAIEAVPGNLLKNENEKFNIVIANILAHIIEEMIEDTYNTLIEDGYFITSGIIEEKYQDIESQMKRIGFKIISVEHDNGWVCIVGQKVSG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARFA_ARATH
Sequence: MAASNHSSGKPGGVLSDALCRELWHACAGPLVTLPREGERVYYFPEGHMEQLEASMHQGLEQQMPSFNLPSKILCKVINIQRRAEPETDEVYAQITLLPELDQSEPTSPDAPVQEPEKCTVHSFCKTLTASDTSTHGGFSVLRRHADDCLPPLDMSQQPPWQELVATDLHNSEWHFRHIFRGQPRRHLLTTGWSVFVSSKKLVAGDAFIFLRGENEELRVGVRRHMRQQTNIPSSVISSHSMHIGVLATAAHAITTGTIFSVFYKPRTSRSEFIVSVNRYLEAKTQKLSVGMRFKMRFEGEEAPEKRFSGTIVGVQENKSSVWHDSEWRSLKVQWDEPSSVFRPERVSPWELEPLVANSTPSSQPQPPQRNKRPRPPGLPSPATGPSGPVTPDGVWKSPADTPSSVPLFSPPAKAATFGHGGNKSFGVSIGSAFWPTNADSAAESFASAFNNESTEKKQTNGNVCRLFGFELVENVNVDECFSAASVSGAVAVDQPVPSNEFDSGQQSEPLNINQSDIPSGSGDPEKSSLRSPQESQSRQIRSCTKVHMQGSAVGRAIDLTRSECYEDLFKKLEEMFDIKGELLESTKKWQVVYTDDEDDMMMVGDDPWNEFCGMVRKIFIYTPEEVKKLSPKNKLAVNARMQLKADAEENGNTEGRSSSMAGSR
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Seems to act as transcriptional repressor.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.  Promotes flowering, stamen development, floral organ abscission and fruit dehiscence.  Acts as repressor of IAA2, IAA3 and IAA7.  Together with RIN13, promotes leaf senescence and cell death (PubMed:32446355).
What are the official names of this protein?
Auxin response factor 1.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates to the nucleus in the presence of RIN13.
Protein: CEBPG_MOUSE
Sequence: MSKLSQPATTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVPPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHSLADNVQPISTETTATNSDNPGQ
What is the function of this protein?
Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272).  Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606).  Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121).  Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity).  Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).
What are the official names of this protein?
CCAAT/enhancer-binding protein gamma, C/EBP gamma, Granulocyte colony-stimulating factor promoter element 1-binding protein, GPE1-BP, GPE1-binding protein, Immunoglobulin enhancer-binding protein 1, IG/EBP-1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. C/EBP subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATA_PYRAE
Sequence: MSGKIEYISGPVVKAELPGARLYELVFVGEIKLFGEVVRIQGEKAFIQVYEDTTGLKPGEPVERTGEPLSAWLGPTIIGKIYDGVQRPLRNIEEISKNPFIARGIGYDKAPPLDLKAEFDFKPAVKPGEEVYPGDVLGSVKETEPMTHYILYPPLPEHAPGVVEWIADGKYKVDDVIARVKTKRGVVEVKMWHKWPVRRPRPFKEKLPPVEPLITGVRTVDTMFPIAKGGTAAVPGPFGSGKTVMIRTLSMFAQSRFIIPVLCGERGNEAADALQGLLKLKDPSTGRPLLERTTIIVNTSNMPVAAREASVYMGTTLGEYFRDQGYDVLVLADSTSRWAEAMREVALRIGEMPSEEGYPAYLPTRLAEFYERAGRVVLYGSKERVGSLTIAASVSPPGGDFTEPVTSNTLRFIGAFWPLSPRLAYSRHYPAIDWLVAFSRYVDTVEVWWSKNVSPEWRRIRDALQSILVKEAELQEIVRILGTEALSEYEKHILNVAFMIREGFLKQDAYNPVDTPSAPIKQFLLMKAIYTYYEEGLKAIESGVPASVLRELETVKRLPRLRMEVTNDVAKEELTKFIESLVAEIRATTNRRG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: AMPL_CAEEL
Sequence: MTQVLVRNGIQAVGDGLTSLIIVGKKSVLKNVTFEGKFKEVAQKFVTDGDSWNSMISRIPASGRHPLHYELAHLITVPDASSRGNTPTNAHSIYKELKPINYPEDTKNVHFVLFAEYPDVLSHVAAIARTFCKFSMKTSGIRELNVNIDVVCDKLTNEDAVFLTDLSESVRETARLIDTPANILTTDALVDEAVKVGNATGSKITVIRGEELLKAGFGGIYHVGKAGPTPPAFVVLSHEVPGSTEHIALVGKGVVYDTGGLQIKTKTGMPNMKRDMGGAAGMLEAYSALVKHGFSQTLHACLCIVENNVSPIANKPDDIIKMLSGKTVEINNTDAEGRLILADGVFYAKETLKATTIFDMATLTGAQAWLSGRLHGAAMTNDEQLENEIIKAGKASGDLVAPMLFAPDLFFGDLKSSIADMKNSNLGKMDGPPSAVAGLFIGAHIGFGEGLRWLHLDIAAPAEVGDRGTGYGPALFSTLLGKYTSVPMLKQ
What is the function of this protein?
Probably acts as a digestive enzyme.
What are the official names of this protein?
Leucine aminopeptidase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
Protein: RPIA_PYRHO
Sequence: MNVEEMKKIAAKEALKFIEDDMVIGLGTGSTTAYFIKLLGEKLKRGEISDIVGVPTSYQAKLLAIEHDIPIASLDQVDAIDVAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVLVDERKLVDYLCQKMPVPIEVIPQAWKAIIEELSIFNAKAELRMGVNKDGPVITDNGNFIIDAKFPRIDDPLDMEIELNTIPGVIENGIFADIADIVIVGTREGVKKLER
What is the function of this protein?
Involved in the first step of the non-oxidative branch of the pentose phosphate pathway.  It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: PYRE_SACD2
Sequence: MQAYQKDFIQLALKAQALKFGEFTLKSGRVSPYFFNAGQFQTGSALASLGRFYAQALVDAGVEFDMIFGPAYKGIPLATTTATALADHHQKDMPFAYNRKEVKAHGEGGTLVGAPIKGRVAIIDDVITAGTAVREVLSLIDAAGAKPAAIVVGLNRQEKGQGELSAIQELEQETGVPVISIINLNHVLQYLETQGDSENLAKVTAYRQQYGVE
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RECA_BACLI
Sequence: MSDRQAALDMALKQIEKQFGKGSIMKLGEQTETRISTVPSGSLALDAALGVGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYAQKLGVNIDELLLSQPDTGEQALEIAEALVRSGAVDIVVIDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSSVRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLGTELDIVQKSGAWYSYQEERLGQGRENAKQFLKENKDILLMIQEQIREHYGLDTGGAAPAQEDEAQAQEELEF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGH_ARATH
Sequence: MGSDEEDFVFHGTPIEREEEIASRKKKAVAGASGNLRTLPAWKQEVTDEEGRRRFHGAFTGGYSAGYYNTVGSKEGWAPQSFTSSRQNRAGARKQSISDFLDEDEKADMEGKSLSASSQFDTFGFTAAEHSRKHAEKEQHERPSAIPGPVPDELVAPVSESIGVKLLLKMGWRRGHSIKEVRASSDARREARKAFLAFYTDENTKETPDSLVSETEVETSLGEDIKISESTPVYVLNPKQDLHGLGYDPFKHAPEFREKKRSRMSANKEVGFRKPLSMKESLFGPKSGKIAPGFGIGALEELDVEDEDVYAGYDFDQTYVIEDEQPARQSNDNRLRLTSKEHDVLPGFGAAKNSDYSMERFNPPIIPKDFVARHKFSGPLEAETKPTVSAPPEVPPPADNNLKLLIEGFATFVSRCGKLYEDLSREKNQSNQLFDFLREGNGHDYYARRLWEEQQKRKDQSKLTLDVKVSPTVQKMTAETRGSLLGEKPLQRSLKETDTSASSGGSFQFPTNLSDTFTKSASSQEAADAVKPFKDDPAKQERFEQFLKEKYKGGLRTTDSNRVNSMSESARAQERLDFEAAAEAIEKGKAYKEVRRATEQPLDFLAGGLQFTSGGTEQIKDTGVVDMKSSKTYPKREEFQWRPSPLLCKRFDLPDPFMGKLPPAPRARNKMDSLVFLPDTVKAASARQVSESQVPKKETSIEEPEVEVEVENVERPVDLYKAIFSDDSEDDEDQPMNGKIQEGQEKKNEAAATTLNRLIAGDFLESLGKELGFEVPMEEEIKSRSKPEDSSDKRLDRPGLKEKVEEKTSSLTLGSEEEKSRKKREKSPGKRSGGNDLSSSESSGDERRRKRYNKKDRHRNDSESDSSSDYHSRDKQGSRSRSKRRESSREKRSSHKKHSKHRRTKKSSSSRYSSDEEQKESRREKKRRRD
What is the function of this protein?
Functions as component of microRNA (miRNA) and small interfering RNA (siRNA) biogenesis.  May assist DCL1 and DCL4 to efficiently process and/or recruit the precursors of miRNAs and siRNAs.  In the miRNA biogenesis pathway, associates with the DCL1 complex that processes primary miRNAs (pri-miRNAs) into miRNAs.  Binds pri-miRNAs and precursor miRNAs (pre-miRNAs).  Is required for the interaction between pri-miRNAs and DRB1 (PubMed:22802657).  Required for general proper plant growth and, in particular, initiation of vascular development.  Interacts genetically with AMP1, a glutamate carboxypeptidase involved in the regulation of meristem function (PubMed:16024589).
What are the official names of this protein?
G patch domain-containing protein TGH, Protein TOUGH.
Protein: BBS5_MACFA
Sequence: MSVLDALWEDRDVRFDLSSQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRILWHSLALSRVNVSVGYNCILNITTRTANSKLRGQTEALYILTKCNSTRFEFIFTNLVPGSPRLFTSVMAVHRAYETSKMYRDFKLRSALIQNKQLRLLPQEHVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVDYEMEEKPQPLEALTVEQIQDDVEIDSDDHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 5 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the BBS5 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to basal bodies.
Protein: STS1_ASPFN
Sequence: MNSLVATPPVPPHFYEYSRLSSSRPMSTPTYTPNSRKRKADDDGNDHDGRMSASPTSSPAFTPRSLPSRNMKRARPNVSGRPLSLPRLLETLDTDALRGVLRSMCERHPGLVDEVVHTAPRPSVSSALQVLRNYQSTLQSSFPLGGNPASDYAYNRVRQPLSNLLDALSDFTPHFLPPNEIQPSLSLNYLDGATEIIHALPRWHTPQNNIERDSAYDEICKAWILVIREAAKRGGGIQLQYGGWDQKLAKHNQNSGGKLQAAVNELGASLGWMHGPETQSHASPGGNDFGSIREQLLSGTYGLGTPVKVGPW
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome sts1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YL205_MIMIV
Sequence: MSISVCYYLSKMSESTKVQFEKKSVGHNSDDEYDDTVPYNEDDETSEEEVQEYNEDEVIHPGFVLKGTYLLLKKIGSGNNASVWMTYHISNDKFLAMKIQDHLCYNDGCREVTIVNKISEYGKNNPDFFCVQLLDHFYFELSDNIKYVCSIYELYAGSIHFLLEEGKYKYGLPLPVVKTIIKQLLTSLSTLHGKLNIIHSDVKPENILFKGLPDYQKNIIKLFNRSGFREKYAELCSEYPNRHENLEIEDEFMDNLEYIAMDAIKEIRILEECLNTNEELIPDDPDNNEKYYDSTDSEEYDYSDNSDYYDDDEDTGPIKKYNERLQSVDDCQEILDCKEICDLDKEYNFATVLNNRESSSDKREIIDDKYVINCQTALTDFGNSYFFDKRTRNEIQDRRYRAPEVILDLNYTFCCDIWSVACVAYELATGYVLFDPFGEHFLNRDLHHLFLIEKIVGEIPLAMKKKSKRRKFLFDKSRGYHIKNVDEFKSTNLETILMNQYLFSKEEAESFANFLMCGLSIDPATRSNADELLKHPWLNDVN
What are the official names of this protein?
Putative serine/threonine-protein kinase L205.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: THS7A_HUMAN
Sequence: MGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM
What is the function of this protein?
The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
What are the official names of this protein?
Thrombospondin type-1 domain-containing protein 7A.
What are the subcellular locations of this protein?
[Thrombospondin type-1 domain-containing protein 7A]: Cell membrane; Single-pass type I membrane protein. Cell projection. Note=Detected on podocyte foot processes. SUBCELLULAR LOCATION: [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted. Note=Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
Protein: DART_MYCTU
Sequence: MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAGRLLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVCKGHSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFDLLCQRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGGVRKYVIKPGMYY
What is the function of this protein?
Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system.  Its toxic effect is neutralized by cognate antitoxin DarG (PubMed:27939941).  ADP-ribosylates ssDNA, preferentially in the motif TTTW.  Uncontrolled expression of DarT leads to ADP-ribosylation of the origin of chromosomal replication DNA in cells (in vitro the most heavily modified motifs are TTTT/A in the OriC lower strand) and growth arrest (PubMed:34408320).  Is very toxic to E. coli, it cannot be expressed in E. coli (PubMed:27939941).  Experiments in situ in which antitoxin DarG levels are depleted (similar to overexpression of DarT) lead to cell death; expression of wild-type DarG protein from M. tuberculosis or T. aquaticus restores growth.  Cells with decreased levels of DarG are more sensitive to bedaquilline (targets respiration), DNA-damaging drugs (mitomycin C, netropsin) and transcription-targeted drugs (rifabutin and rifampicin).  When DarG is depleted, a DNA-damage response is induced and mutability is increased, suggesting ADP-ribosylation of DNA is the toxic effect (PubMed:32634279).
What are the official names of this protein?
DNA ADP-ribosyl transferase, DarT, Toxin DarT.
What is the protein family that this protein belongs to?
Belongs to the DarT ADP-ribosyltransferase family.
Protein: YFJZ_ECOLI
Sequence: MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR
What is the function of this protein?
Antitoxin component of a type IV toxin-antitoxin (TA) system.  Antitoxin that counteracts the effect of cognate toxin YpjF (PubMed:28257056).  Also counteracts the effect of non-cognate toxins CbtA and YfkI (PubMed:28257056).
What are the official names of this protein?
Antitoxin YfjZ.
What is the protein family that this protein belongs to?
Belongs to the CbeA/YafW/YfjZ antitoxin family.