PharMolix/UniProtQA huggingface dataset:
Protein: MURC_MYXXD
Sequence: MTRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMGATFFEGHRAQNLIQADVVVISSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAVAGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAKLGKSELMVVEADESDGSFLHLHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEKRFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAEEMDIPLETVRESLAEFGGVQRRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRVVVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEERIHGATGDALADAVRAHGHRDVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_ESCF3
Sequence: MSNFLPFSRPAMGAEELAAVKEVLESGWITTGPKNLALEDAFIQLTGNQYAIAVSSATAGMHITLMALEIGPGDEVITPSMTWVSTLNMISLLGATPVMVDVDRDTLMVTPEIVEAAITPRTKAIIPVHYAGAPADTNALYAIAERHGIAVIEDAAHAVGTYYKGQHVGARGTAIFSFHAIKNITCAEGGLVVTDDESLARQLRTLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLHKLEQLNARRHDIATQYQHALVNLPFQPLALPAWPHIHSWHLFIIRVDEQRCGINRDTLMEALKEKGIGTGLHFRAAHTQKYYRQHFPDLSLPNTEWNSERICSLPLFPDMTNADAERVITALHQLAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: RL7_RUEST
Sequence: MADLKALAESIVGLTLLEAQELKTILKDEYGIEPAAGGAVMVAAGGDAAGGAAEEEKTEFDVVLKNAGASKINVIKEVRGITGLGLKEAKELVEAGGKIKEGVDKAEAEDIKGKLEAAGAEVELA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: NU2M_DROSE
Sequence: STVLLFSSILLMLKNNLNNEINESFTSMIIMSALLLKSGAAPFHFWFPNMMEGLTWMNALMLMTWQKIAPLMLISYLNIKYLLLISVILSVIIGAIGGLNQTSLRKLMAFSSINHLGWMLSSLMFSESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFLLTLMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMISNNTNMYLIMTFFSIFGLFMISLFYFMF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RSMA_BORBR
Sequence: MSAHQARKRFGQHFLTDESVVESIVRAIGPARDDRVVEIGPGLSALTRPLLDRIDHLTAVEIDRDLAARLRRQYPAERLTVVEADALTVDFAQFGQGLRVVGNLPYNISSPLLFHLMGAAEQVRDQHFMLQREVIDRMVAEPGSGDYSRLSVMLQARYRMEKLFDVAPEAFDPPPRVVSAVVRMAPLPADRLRPASDAAFETVVARAFSQRRKMLRRVLGDWAALTPWDELGIAPTARAEEVGVAQFIGLADALLAAGAPGLARP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC2_CANAL
Sequence: MSSQADYDKRLAEEVGSLSTRLVTAVNKQVELEETILELRKQVSALKLKNEQLNQSDIKLKTILPKYIKLQDDYRETLTKKKEAESQNTKLQGEVEDLTASLFDEANTMVSNASRETHNFKIKNRKLYEELDEKNIIINDLQEQLQDLKQMFIKMEEQSKIQSYSQSNTPKIESSTDFNETNSIHTNTNFSESKLSKYNTRSTLGDEESQNYNLQQLQRIIYSPLITSIRFDLNNYNIDFKGFVYQLIKPDFQFDLSHLKTIPFFKSIWQSEIENCIHYIPSLPATTTLLNRWQKGKTFWGSLIEGKVSIEPIKGSNETFKLTYKGNNASGNSSNENTESISNRSSATGSVVPVAIKDPCTFCGEARNDSLEHCRLYHLKLFESNTANNSGNNSTNQDQQGNNDNTHVIASYPLCNYCLIKLRNLCDFFAKIRLIRSNIFKLKQNDSFDEFIVVPGSFGQFKRSNTISNRNGTYSSSSTSSSSTSSVSSSSATTANGESLNSTTHNIQLERTEESKLIKLYIMMLLIRSKIFWSKLGFWDTIDQINEINLDEIHYEAFSYLIPKPTQQQQQQQGDIRSQSNFNSPRQSVDGRSVLSGSISSPRQPNLDKQQKDSIVDETVAQLQRDGVVRSETASAEEKFEDAISDETNGQEQLRSEKLQTGKTVTEPNSVSESEPVQEPEQVRSKSNNNTNNKNKDTKIEDSDAEHTFSLKRSHSKQFKDQLNKELDQTLEMLAENIDFDESSNGNGNGN
What is the function of this protein?
Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP.  Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis (By similarity).  Required for filamentous growth.
What are the official names of this protein?
Rab guanine nucleotide exchange factor SEC2, GDP-GTP exchange factor SEC2.
What is the protein family that this protein belongs to?
Belongs to the SEC2 family.
What are the subcellular locations of this protein?
Bud neck. Bud tip. Cytoplasmic vesicle, secretory vesicle. Note=Localizes to the spitzenkorper, a structure found in fungal hyphae which is the organizing center for hyphal growth and morphogenesis.
Protein: PRIA_SYNY3
Sequence: MTVSPSALAELGFNYQEEDSVRPWAAVLVDLPQNEGVYTYAIPPGLTVQDGDIVAVPFGNQQLGGIVVGCLTKLPPDLPPEKIKPIQDVIVSGFFAPHYWRLLHWLAEYYCTELITVIRMALPPGLLQRSQRRIKLNGDRLPSDWPLFLSQPSHQGARQILTLLQSSKEGDYSYRYLRQKVPGLTKALRDLLKRQWVESYLEPPKAVQPQLPKMVTLLNFDPSFKLTELQARTLIVLKNQGGEMWLADLLKAVPCSASTIQSLAKKGLVAIAEREKLRLFQQPSINASQAPELTPAQKQACQTVLPLQGYHQVLLHGVTGSGKTEVYLQICGDRLGKGQSVLVLVPEIGLTPQLTDRFRARFGNKVAVYHSGLSSGEKYDTWRQTLLGHEQIVIGTRSAIFTPLPNLGLIILDEEHDSSFKQTQLTPNYHARTVAQRRAELEQCPLILGSATPSLESWHTVHRHQNDPQRHYLELPERVQSRPLPPVQIVDMRAELKQGNRSIFSRALQTALGELKAKQQQGILFINRRGHSTFVSCRSCGYVLECPNCDVSLSYHYVQGNGQPLLRCHYCNHAEIQPKVCPECSSPYLKFFGSGTQKVTEALTQEFPDLRWIRFDSDTTRRKGAHRALLDQFQRGEADLLVGTQMLTKGLDLAQITLVGVVAADSLLNFADYRSAERGFQTLTQVSGRAGRGEEPGQVIIQTYTPRHPVIQAVKTHNYHGFIAQELPQREMLNYPPYGKLILLRCLGTNEREVEKTIQAIAVLCEQLLPKTVEILGPAPASILRIAQRYRWQLLVKYPSFIKVILPLERIKQICPSSVYLDIDVDPLSID
What is the function of this protein?
Involved in the restart of stalled replication forks.  Recognizes and binds the arrested nascent DNA chain at stalled replication forks.  It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
What are the official names of this protein?
Primosomal protein N', ATP-dependent helicase PriA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PriA subfamily.
Protein: NOPL_SINFN
Sequence: MDINSTSPLNASPQPDSPPPANASAFAHQLSGFQYSPPHAADSLLPQVEADSPYLDTRHPYSQYLDSAYPYPSPCEWQHDLYTRTRERSPHPSEQRPHARVLQGAPEHDQDQHLEAAGPREGSWQVGPSRSGPSQAGLSPSATPLNPSPPPHATDLETKHPYSQYLDWANPSLLDWQQDLHTRATASPAPLTAERGRSPQPSEQQPHARALQVPEYDQDLIWQRVDAAGPQAGPWQVGPSHSGPSQARPSHAWPSSSAGAEPAELSDFVMDSGVRAWDHWFLAPHMASEDQMSMLRATGLMPTAEVPTTTFLMMGMRHVAEFRGEGVIRIRPSVDFDI
What is the function of this protein?
Putative symbiotic effector that modulates nodulation in legumes.  When delivered into the plant cell, modulates the activity of signal transduction pathways that culminate in activation of PR proteins.
What are the official names of this protein?
Nodulation outer protein L.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by the type II secretion system and delivered into the host plant cytoplasm.
Protein: NUOD_FRAAA
Sequence: MTPSTSTPHTSTAPHTSTGQSTDGAAQPGDGSSAYEAGFTESASGRVYTVTGGDWEEILGAGEQDAERIVVNMGPQHPSTHGVLRLVLEIDGETVTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSPLYNEAAYCLSVEKLLGITDDIPERATVIRVLVMELQRIASHLVWLATGGMELGATTAMIFGFREREKVLDLLELITGLRMNHAFIRPGGLAQDLPDGTERAIREFLADMPKRIREYHRLLTGQPIWKARMVDVNVLDAAGCIALGVTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTALEADSFARYLVRLEEMGESLKIIEQCLDRLRPGPVMVADKKIAWPAQLSIGADGMGNSLAHIRNIMGTSMEALIHHFKLVTEGFRVPPGQVYTQIESPRGELGYHVVSDGGTRPFRVHVRDPSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCH4_DICTD
Sequence: MKDVQNERDYRGIYLRKVGIKNIHWPIKIITKSGEYQSTVANIDISVDLREDLRGTHMSRFVEVLNGIDFLHPENLGKILQEVREKLKADSSHIKITFPYFIFKKTPVSQIASPNMIECVIEAELSKKLYMIIGVKVPIHTLCPCSKEISEYGAHNQRAIAEIYIKSKKLIWFEDLVEIAERSASAPIYSLLKRPDEKYITETAYNNPKFVEDVVRDIVSELEKEPKISWYRVEVTSFESIHNHNAFACVEKGWIKK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: MOAC_CORGB
Sequence: MSKLTHVREDGSAHMVDVTGKNETSRTAVAEGFVKMRGDVVKQLFSAGLPKGDALPVARIAGIMGAKKTPDIIPLCHPLPLGKITVDFFELADGVRIEASVKTRGVTGVEMEALTAVSTAALTVYDMIKAVDKMAVIDGIRVLSKTGGKSGDWSVQ
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: SAHH_BRUC2
Sequence: MTASQDFVVKDISLADWGRKELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA52_MACFA
Sequence: MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHLIFPLGCTILIQAINTQEQNFLQGHGNNVSCLAISRSGRYIASGQVTFMGFKADIILWDYKKRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSIGMADDDSFFYLGTTTGDILKMNPRTKLLTDAGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPSYKPIKKIQSQGGITSITLRGEGHQFFVGTEESHIYRVSFTDFKETLIATCHFEAVEDIVFPFGTAELFATCAKKDIRVWHTSSNSAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).  Important for proper ciliary and flagellar beating.  May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11.  May play a role in cell growth and/or survival (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 52, WD repeat-containing protein 16.
What is the protein family that this protein belongs to?
Belongs to the CFAP52 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Note=Located in the proximal region of respiratory cilia.
Protein: ATG16_EMENI
Sequence: MAHWREEYAAALAARDRREKANVAIYNAYSQLADRTASSMIAVSDLQSDAQRSALSTPVADPRQQQPSPASGPSPQDIILAIRADLAEAQRSRSELEEQLARVTTELEKLRRRNIQNGKRISSMESEITHLQLRLKDRDEELREKAKLLEGFQDEIATFELQLNMAEERSNRLQKENQELIDRWMARMGKEADAMNDAYQFS
What is the function of this protein?
Stabilizes the atg5-atg12 conjugate which is necessary for autophagy.  The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS).  Recruits also ATG3 to the PAS.  Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
What are the official names of this protein?
Autophagy protein 16.
What is the protein family that this protein belongs to?
Belongs to the ATG16 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: PCYA_PROMA
Sequence: MFAKSFPLNPFLESVADRIRERVKGLTGVESLELAPDLKNIYGKTDGEDFFIFNELHQSRGFRKLHIETAVFEPSLEILHVVFFPDPAFDLPIFGVDLIAVPQGISAAIVDLSPVRDKLPRTIENQLAQIEIPSFEKVRKLPDWGDIFSSHVQFITPIGAEENGFFLDLVDKFLTILIDYSESIEPDLDDSPFTIERIEGQMYYCLQQKQNDKTRNVLAKAFSPNWANQYIEMVLFDMPVHTKNLDN
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: MAO1_SHEB5
Sequence: MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDTNETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLIQFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGAGSAGCGIAEAIVAQMVSEGISDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQNWSNFSDNISLLDVVNNTKPTVLIGVSGVPGLFTEEIIRAMHSHCARPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVSDAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEILQQSIEGNFWSPEYRRYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: EFP_ACIB5
Sequence: MANYSTNDFKPGLKVMLDSNPCSIMENEYVKPGKGQAFNRVKLRNLKTGKVLEKTFKSGDTLEAADIVEVEMNYLYNDGEMWHFMDPESFEQIAADKTAMGDAAKWLKDDSNETCTIMLFNGVPLNVNAPNFVVLKVVETDPGVRGDTSGGGGKPAKLETGAVVRVPLFVQQEESVRVDTRTGEYLERA
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFN1_HUMAN
Sequence: MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSSNEES
What is the function of this protein?
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303).  Membrane clustering requires GTPase activity (PubMed:27920125).  It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303).  Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376).  Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376).  Has low GTPase activity (PubMed:27920125, PubMed:28114303).
What are the official names of this protein?
Mitofusin-1, Fzo homolog, Transmembrane GTPase MFN1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: SYS_FUSNN
Sequence: MLELKFMRENVEMLKEMLKNRNSNVDMDAFVELDSKRREVLSEVENLKRERNNASAEIANLKKEKKNADHIIEKMGEVSTKIKDLDAELVEIDEKIKDIQLNIPNVYHPSTPIGPDEDYNLEIRKWGIPKKFDFEPKSHWDIGEDLGILDFERGAKLSGSRFVLYRGAAARLERAIINFMLDVHTLEEGYTEHITPFMVKAEVCEGTGQLPKFEEDMYKTTDDMYLISTSEITMTNIHRKEILEQAELPKYYTAYSPCFRREAGSYGKDVKGLIRLHQFNKVEMVKITDAESSYDELEKMVNNAETILQRLELPYRVIQLCSGDLGFSAAKTYDLEVWLPSQNKYREISSCSNCEAFQARRMGLKYRVPNGSEFCHTLNGSGLAVGRTLVAIMENYQQEDGSFLVPKVLIPYMGGVDVIKK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_METFK
Sequence: MSNERVLICGVDEAGRGPLAGAVYAAAVILDPQHPIPGLADSKTLSEKKRDMLAIEIKQHALAWTIASCSAEEIDEINILQASLLAMKRAIDQLTIMPTQVLVDGLHCPGIAIPAQGIVKGDSKVQEIAAASILAKTARDHEMVEMHARYPQYDFAKHKGYPTAHHLRLLAEHGACEIHRRSYAPVKKVLGLV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMAL_DROME
Sequence: MARLRLLIGLIFCLAISLDSVLSAPVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIPVPSLS
What are the official names of this protein?
Protein amalgam.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: SYI_DECAR
Sequence: MADYKDSLNLPDTAFPMRGDLPKREPQWVAQWQEKKLYQRIREICAGRPRFTLHDGPPYANGDIHIGHAVNKVLKDIIVRSKTLSGFDAPYVPGWDCHGLPIEHQIEKLHGKAIPADKVRELSRAYAAEQVERQKKDFIRLGVLGDWGNPYLTMNFSAEAGEIRALGKILEQGYLYQGLKPVNWCLDCGSALAEAEVEYEDKNSPAIDVAFEVHENHTAKLAAAFGLTHLRGPAFAVIWTTTPWTLPANEAVSVHPDLTYDLIETEKGALILVRELAEAALKRYGLEGTVAGSCTGDKLDQMLLKHPFQNRDVAIICGTHVTTEAGTGLVHTAPAHGVDDYNIGKKYGLPVNNPVGNDGKFISTTPALSVGELAGKTVWEANPQVLQELEARARLLKNERIQHSYPHCWRHKTPIIFRATTQWFIGMENKKNEDASTLRWIAERAVDETQFFPAWGRARLEGMMKTRPDWCVSRQRNWGVPIPFFLHKETGQPHPRTAELIEQVALRVEKSGIEAWFSLDAAELLGAEADQYVKMKDTLDVWFDSGTTHWHVMRGSHAADHTYPADLYLEGSDQHRGWFQSSLLSGCAIDGRAPYKGLLTHGFVVDGKGHKMSKSKGNVIAPQQVSDKMGADILRLWTASTDYSGELTISDEILKRVVEGYRRIRNTLRFLLANVSDFDAATDMLPIDQWLEIDRYALALTRELQDGCRADFDKYEFHRVVQALQTFCSEDLGGFYLDILKDRLYTTAPKSVARRSAQSALWHITQAFVRLLAPITAFTAEEVWQVLTGKADDSVMFQVWHDLPALAGEGDLLAKWALIRTARADVTKALEAQREAGKIGSALQAAVEIHCGGEKYEALASLGDDLKFVFICSSTVAVRDDNEQVIATPLEHAKCERCWHVREDVGANTEHPTLCGRCVSNLYGEGEVRGCA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_WOLSU
Sequence: MSKKLHLISLGCTKNLVDSEVMLGRLKSYEITPLIEKADVIIVNTCGFIEAAKQESLSVLFEALERRKKGAILVASGCLSERYHEELLREIPEIDIITGVGDYDKIDQMVRERQGFHSGEVFLASEEQERVITGSSVHAYVKLSEGCNQTCSFCAIPQFKGKLHSRTLESTLKEVKNLIAKGFTDFSFIAQDTSSYLRDRGEKEGLIQLIGALDSLEGIKSARILYLYPSTASAKLIQAIQKSQVVQNYFDMPLQHIAESMLKRMKRGANQKKHKELLERMRQVPHSFVRTTLILGHPGESEEEFEELCRFLEEFRFDRVNLFAYSDEEGTSAHKMEGKLDKRVINARLKRLDKIIQKQHRALLKEMVGQEIPVILEGGSSEHEFFYSARDARWAPEIDGEILINETLLPQPAPGHYWAKITQVAGKQLLATLTRRWEK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.