PharMolix/UniProtQA huggingface dataset:
Protein: SMAD4_RAT
Sequence: MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
What is the function of this protein?
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor).  Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.  Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.  Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta.  Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.  Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.  May act as a tumor suppressor.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.  In muscle physiology, plays a central role in the balance between atrophy and hypertrophy.  When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4.  MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
What are the official names of this protein?
Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, SMAD family member 4, SMAD 4, Smad4.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation.
Protein: RSME_ECOLI
Sequence: MRIPRIYHPEPLTSHSHIALCEDAANHIGRVLRMGPGQALQLFDGSNQVFDAEITSASKKSVEVKVLEGQIDDRESPLHIHLGQVMSRGEKMEFTIQKSIELGVSLITPLFSERCGVKLDSERLNKKLQQWQKIAIAACEQCGRNRVPEIRPAMDLEAWCAEQDEGLKLNLHPRASNSINTLPLPVERVRLLIGPEGGLSADEIAMTARYQFTDILLGPRVLRTETTALTAITALQVRFGDLG
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E, 16S rRNA m3U1498 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRQ_ECO45
Sequence: MRLTAKQVTWLKVCLHLAGLLPFLWLAWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLLSLFNQLRKQVHNKLSL
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CODY_BACP2
Sequence: MALLQKTRIINSMLQDAAGKPVNFKEMAETLRDVIDSNIFVLSRRGKLLGYSINQQIENPRMKKMLEDRQFPEEYTKSLFNIPETSSNLDINSEYTAFPIENRDLFESGLTTIVPIIGGGDRLGTLILSRLQDTFKDDDLILAEYGATVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPRV_DICNO
Sequence: MNLSNISAVKVLTLVVSAAIAGQVCAAESIVNYESANAISKQPEGSVRFIVKYKDGTPSSQGLKTRSTTKVMASGMQVAGFEAQFVRTTGLGAGIFAVPELKTTKEAHLVMDTIASNPDVEFVEVDRLAYPKAAPNDPSYRQQWHYFGNYGVKANKVWDRGFTGQGVVVSVVDTGILDHVDLNGNMLPGYDFISSAPNARDGDQRDNNPADEGDWFDNWDCGGYPDPRREKKFSTWHGSHVAGTIAAVTNNGVGVAGVAYGAKVIPVRVLGKCGGYDSDITDGMYWSAGGHIDGVPDNQNPAQVVNMSLGGGGGCSQNSQRMIDKTTNLGALIVIAAGNENQDASRTWPSSCNNVLSVGATTPKGKRAPFSNYGARVHLAAPGTNILSTIDVGQAGPVRSSYGMKAGTSMAAPHVSGVAALVISAANSIGKTLTPSELSDILVRTTSRFNGRLDRGLGSGIVDANAAVNAVLGDQNRAQPRPPVNQPINSGNKVYRSDRRVAIRDLRSVTSGIRVNDQARVGSANITLTLDIRYGDRSQLAVELIAPSGRVYPIYHDGKRQPNIVGPATFSVKNERLQGTWTLKVTDKARGVTGSIDSWSLTF
What are the official names of this protein?
Extracellular basic protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_KOSOT
Sequence: MSNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAIKEAYGKNLDYEIVYETTEPEAFNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENRVLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKIMELHPEMRVLYITSEQFMNDMIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICSDRNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADSVDGNLRILRGVIIKLIVQSSINKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEAVMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEISKITGKRHSTVIHSIKKIEMSVIKGNTVVKEKLAKILNTMATSSAAG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSPG2_DICDI
Sequence: MATIFDILKTLNNNNNNINNNKIESCKRQYTVNKRIDIIPSMDVTMTNDKLIIETELPGVSKNDIDINIKDSILIIQGEKKNNIIKLQQQQQQQSEKSSQSTNNKDDDEPSIEEYEDDTKLKSNLNKNTENKDENKTTSSITNKKFISERSFGNFKRYLNLSEILYQLDLNSINTQFENGLLTITINKKSDNFQIKLKSI
What are the official names of this protein?
Small heat shock protein hspG2.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: RL35A_DICDI
Sequence: MEKIYSKGVVLGYRRSQATQYPNISLIKIEGVVSREDSTFYLGKKVCLVSKVSKSAKNPTGHKISWGKICKTHGSSGVVQARFARNLPPKAMGAPVRVMLYPSNI
What is the function of this protein?
The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.
What are the official names of this protein?
60S ribosomal protein L35a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL33 family.
Protein: EXG1_YEAST
Sequence: MLSLKTLLCTLLTVSSVLATPVPARDPSSIQFVHEENKKRYYDYDHGSLGEPIRGVNIGGWLLLEPYITPSLFEAFRTNDDNDEGIPVDEYHFCQYLGKDLAKSRLQSHWSTFYQEQDFANIASQGFNLVRIPIGYWAFQTLDDDPYVSGLQESYLDQAIGWARNNSLKVWVDLHGAAGSQNGFDNSGLRDSYKFLEDSNLAVTTNVLNYILKKYSAEEYLDTVIGIELINEPLGPVLDMDKMKNDYLAPAYEYLRNNIKSDQVIIIHDAFQPYNYWDDFMTENDGYWGVTIDHHHYQVFASDQLERSIDEHIKVACEWGTGVLNESHWTVCGEFAAALTDCTKWLNSVGFGARYDGSWVNGDQTSSYIGSCANNDDIAYWSDERKENTRRYVEAQLDAFEMRGGWIIWCYKTESSLEWDAQRLMFNGLFPQPLTDRKYPNQCGTISN
What is the function of this protein?
Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.  This enzyme hydrolyzes both 1,3-beta- and 1,6-beta-linkages and even has beta-glucosidase activity.  It could also function biosynthetically as a transglycosylase.
What are the official names of this protein?
Glucan 1,3-beta-glucosidase I/II, Exo-1,3-beta-glucanase I/II, Soluble cell wall protein 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted.
Protein: ISPE_STAA3
Sequence: MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: UBIC_ECO81
Sequence: MSHPALTQLRALRYFTEIPALEPQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CERH_CAUVN
Sequence: MAKTASDISLTRQAMSLTEDLMTPNAAIYWADLTISAAVMWGGFLIAATTSSLALGLGAALLSMLALYRGLSFIHELTHIRDDEAPGFRVGWNVLVGVPLMTPSLMYEGVHNIHHIKDRFGTRLDPEYLPLSRFTPLKLAGFLFIALLAPLGVILRSAILIPLSFLVPSLRRYLKTKLSALIINPDFVREDLGRWRKAWVIQDVACWLWSWAVIAGLGLGVVPVRVVLTGLAIFSLATFLNQARTLVAHHWDNDGDKMTLEEQFLDSVNVPPPNLASALWAPVGLRYHALHHLLPRLPYHNMAKAHARLVEALGADSLYHRASEPGLFEALGDLFRRVRQKNAEARNQPAH
What is the function of this protein?
Involved in de novo bacterial ceramide synthesis.
What are the official names of this protein?
Ceramide hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RCSA_KLEAE
Sequence: MSTMIMDLCSYTRLGLTGYLTSRGIKKQEIVEVNSAADLQKHCTSCCPAVVFLNEDCFVHDDESNGIIRQIITQNPATLFVIFMSLANIHFDRYLRVRKNLLISSKSITPKDLDVILVNYLKYKNTSVGQLTLPTLSLSKTESNMLQMWMAGHGTSQISTQMNIKAKTVSSHKGNIKKKIQTHNKQVIYHIVRLTENITSGIQVNMR
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  Binds to DNA to regulate expression of genes.
What are the official names of this protein?
Transcriptional regulatory protein RcsA.
What is the protein family that this protein belongs to?
Belongs to the RcsA family.
Protein: ACP_XANC5
Sequence: MSTIEERVKKIVVEQLGVKEEEVTTSASFVDDLGADSLDTVELVMALEEEFECEIPDEEAEKITSVQQAIDYVKAHVKS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_BRADU
Sequence: MNGSSANPRAALSSAMTDPFGRTISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEELDRLCSAFIAKGVKKLRLTGGEPLVRRNVMTLVRSLSRHLSSGALSELTLTTNGTQLAKYARELADCGVRRINVSLDTLDPKKFREITRWGEIDKVLEGIEAARAAGLAVKINAVALKNLNEDELPSLMRWAHGKNMGLTLIEVMPMGEIGAGRIDQYLPLSLVRARLAQQFTLMDLAESTGGPARYVSVAETGGKLGFITPMTHNFCESCNRVRITCTGTLHTCLGHEDASDLRKPLRASDDDMLLADAIDRAIGLKPKGHDFIIDRRHNRPSVSRHMSVTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: SYC_ANAD2
Sequence: MSIQVHDTLTAQKRELVPLEPGKLRLYVCGPTVYDYSHLGHARCYVVWDVVVRHLRARGLEVRFVRNFTDVDDKIIQRANERGEDPIALASRFADAFHEDMDALGNLRPDVEPRVSGHIPEIVALIARLVERGFAYAPGNGDVYYAVRKFPEYGRLSKRNLDDLIAGARVEPGEAKRDPLDFALWKAAKPGEPAWESPWGKGRPGWHIECSAMTQKHLGAPIDLHAGGKDLVFPHHTNEIAQSVAATSDGLHAEDFARYWMHNGFVQIDDEKMSKSLGNFFTIRDVLARFDGEALRFFLLGTHYRRDFNFSDQVLAEAERRLSALYETVEKAERLGAGAAPAAEPAFVERARAALDDDFNTPQVLGIVAEAFTEANALADRKGKKSSEEKARLAAFARGARAVGAVLGILDRPPAQALTAIRDRAAARRGIDGGEVERSIAERAAARAAKDFARSDAIRDALLARGVVLMDGPQGTTWKVE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLAP_LYSSH
Sequence: MAKQNKGRKFFAASATAALVASAIVPVASAAQLNDFNKISGYAKEAVQSLVDAGVIQGDANGNFNPLKTISRAEAATIFTNALELEAEGDVNFKDVKADAWYYDAIAATVENGIFEGVSATEFAPNKQLTRSEAAKILVDAFELEGEGDLSEFADASTVKPWAKSYLEIAVANGVIKGSEANGKTNLNPNAPITRQDFAVVFSRTIENVDATPKVDKIEVVDAKTLNVTLSDGTKETVTLEKALEPNKETEVTFKIKDVEYKAKVTYVVTTATAVKSVSATNLKEVVVEFDGTVDKETAEDAANYALKSGKTIKSVSLAADNKTATVTLTDKLNNNKADAISISNVKAGDKEINVKNVEFTAVDNKIPEVTEVKSLGTKAVKVTLSEPVENLSSTNFTLDGKAYFGNVVMGAGNKTVILTPYSSSALSVGDHKLTVSGAKDFAGFVSLNSTHEFKVVEDKEAPTVTEATATLETVTLTFSEDIDMDTVKASNVYWKSGDSKKEASEFERIADNKYKFVFKGSEKTLPTGKVDVYVEDIKDYSDNKIAKDTKVTVTPEIDQTRPEVRKVTALDEKTIKVTFSKTVDGESAIKTGNYTVKDKDDKVVSVDKVTVDSKDSKSVIIDLYSKVSVGENTITIKNVKDATKLNNTMLDYTGKFTRSDKEGPDYEHVINADAKAKKVVLKFDKKMDAASLADYSNYLVKINDTLQTLSEDVATLSVSNDATVVTITFAETIKGDDVVFASGKAISGSGKVNVNELQVMGVKDTSGNVHKKFNGSENKITLSSTSTPLKLAKIDKDYDAKYTAELVDRKTVKVKFSTVINSAAANAFTSESHKIDSIQVNGTSTVTVKFKDEINTNASDLDLKVNLSKLVDIAGNESTNNTPIAIKAGINLLDSVAPVVVGEPVVDKETITFTFSENLTSVSIGEVLSTDFTVTRVSDNKDLAIKDYSVAIANNNQVVITLSDNREVATAYKVTAKNAKLITDDNGDKKNAIADFTKTTATKVEASGTLSLDAAKTNLNNEITKAKDAKATGTEGTAATNQIVGSKDALQVAIDVAELVKNDTAATLQQLTDAKTDLTAAITAYNAAKVEDISSLLVAPDLVLGTTDNGTITGFVAGTGETLKVTSDSAANVEVTDPTGLAVTAKAKGEANILVQVLKGDKVIKTGTVKVTVSE
What is the function of this protein?
The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.
What are the official names of this protein?
Surface-layer 125 kDa protein.
What are the subcellular locations of this protein?
Secreted, cell wall, S-layer.
Protein: BRXL4_ARATH
Sequence: MLTCIARSKRAGDESSGQPDDPDSKNAKSLTSQLKDMALKASGAYRHCTPCTAAQGQGQGQGPIKNNPSSSSVKSDFESDQRFKMLYGRSNSSITATAAVAATQQQQPRVWGKEMEARLKGISSGEATPKSASGRNRVDPIVFVEEKEPKEWVAQVEPGVLITFVSLPGGGNDLKRIRFSRDMFNKLQAQRWWADNYDKVMELYNVQKLSRQAFPLPTPPRSEDENAKVEYHPEDTPATPPLNKERLPRTIHRPPGLAAYSSSDSLDHNSMQSQQFYDSGLLNSTPKVSSISVAKTETSSIDASIRSSSSRDADRSEEMSVSNASDVDNEWVEQDEPGVYITIKVLPGGKRELRRVRFSRERFGEMHARLWWEENRARIHEQYL
What are the official names of this protein?
Protein Brevis radix-like 4, AtBRXL4.
What is the protein family that this protein belongs to?
Belongs to the BRX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CBPC1_XENTR
Sequence: MSKAKATADKCLSNNSRIQSLLSQLEKVNAEPLLFDSDNTRYVTAKILHLAQTQEKTRKEIAAKGSTGMEVILCTLENTRDLQTILNILNILNELASTAGGRRINALISKGGSRILLQLLLSASKESSSNEELMMVLHSLLAKVGPKDKKFGIKARVSGALNISLNLVKQNLQNPRLILPCLQVLRVCCMNSVNSVYLGKNGAVEILFKLIGPFTRRNTGLIKVSLDTFAALLKSKTNARKAVDRGYVQALLSIYTDWHRHDTRHRHMLIRKGILQCLKSITNIKIGRKAFIDANGMKTLYNTSQECQAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSAFQFQLPIMPTSGPVALLYSMPPEVDDVVDESDDNDDTEAETEAEAENEESDQLCKNDDIETDITKLIPGQELGRTLEDLKMYERFFPELTEDFQEFDLVSNEPKPGAKLGPIIVPTAGEEQPEVPNNFMKDLEKRSCNISLEDECNKRPTFLDMPKNVTNKGNDGLGQQVHGDIDRSCYYFSSDIVKDLEKLSLRKPSGNHPCRNGCVSAKDKPIFLPHPCNKSTSNSGSCSNNLFEKHSMHLSPLCCSGITPDDDESSPLDELAMREITDFDNLLPLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHVPPFFKERLLERPYGVQRSKIFQDIERMIHPNDIIDRVVYDLDNSSCSAQDESEVLKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRTGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALASRPWWYRVGMDICYYKNHFSRSSIATGGQKGKSYYTITFTVTFPHRDDVCYFAYHYPYTYSTLKMHLKKLESLHNPQQVYFRQEVLCETLGGNGCPVITITAMPESNYYEHVYQFRNRPYIFLSSRVHPGETNASWVMKGTLEFLMGSSTSAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQNPNVDLHPTIYHTKGLLQYLAAIRRTPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNANAASCDMVEDSGYRTLPKVLNQLAPAFSMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKDLQIGTKELEEMGAKFCVGLLRLKRLTSPMELTLPPSLIDIENELIESSCKVASPTTYVLEDDEPRFLEEVDYSAESNDDADPDLPDTIGDFENTALEEEGFSDSEITRTHTSGQST
What is the function of this protein?
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins.  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin.  Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate.  Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.
What are the official names of this protein?
Cytosolic carboxypeptidase 1, ATP/GTP-binding protein 1, Protein deglutamylase CCP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion.
Protein: RS14_CANAX
Sequence: MYYTSYRSQVFGVARIFASFNDTFVHVTDLSGKETIARVTGGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITAVHIKLRATGGTKTKTPGPGGQSALRALARSGLRIGRIEDVTPVPSDSTRRKGGRRGRRL
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PISD_BOVIN
Sequence: MPGKSTRPLPAPRPCCAPCPFWSPRLAGMQGTGSTRSTGSESWRSWAWTSRPSLLVTGRLHFPQLALRRRLGQLSCMSKPALKLRSWPLTVLYYLLPLGALRPLSRVGWRPVSRVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGKILNFGQVKNCEVEQVKGVTYSLESFLGPRTPSEDLPFPPATPHSSFRSQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRYSKGSYNDFSFVTHANKEGIPMRKGEHLGEFNLGSTIVLIFEAPKDFNFRLQAGQKIRFGEALGSL
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.  May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
[Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.
Protein: RTCA_SULIY
Sequence: MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILINNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLAR_ECOLI
Sequence: MTITSLDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLRRTVLSVEMLEDKHDQHQTLTAAVLARDTARASELMRQHLLTPIPIIQQAMAGN
What is the function of this protein?
Negatively regulates the expression of the glaH-lhgD-gabDTP operon in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation (PubMed:14731280, PubMed:30498244).  Thereby is involved in the regulation of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).  Binds to two primary and two secondary sites in the promoter region of the glaH operon with the consensus sequences TTGTN5TTTT and ATGTN5TTTT of the primary sites, each separated by six nucleotides (PubMed:30498244).
What are the official names of this protein?
HTH-type transcriptional repressor GlaR, Carbon starvation induced regulator, GlaH operon repressor.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT3_XENLA
Sequence: MCDDDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIQRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLAYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility.
What are the official names of this protein?
Actin, alpha skeletal muscle 3, Actin alpha 3, Femoral (alpha 3) actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SLD2_YARLI
Sequence: MDIQTLRSEIKAWERAYADKHGRKPTPKEVKADPIAKKYHLYNKFKKAESAGTGPSTPKRASKLHSSLNYKPVSFSVKTPEKQISKNRRRSVSKQQHADIVTPSHRSLTFSKAPALSRTPQKQLQDTPKAATPKPSPSVPLGPTPSIHGRVVSLLEGLDGTPVKEFATPGNVSTPVKVVSITSETPTNKPALDVNDEFTTPAYLNRISVDVSPFEKRLSFAERIRQSVVESPIKQMSPEKELSPANQTEEYDDDEDAWRELEGLPPKPKEPKIVDVTFDGEEPDELDEIMGTVEVHNPYDEPVQDDLDWVHETALEGETALSAPIYKEGGIKKRKHQTQKRTTKKAIVRVESEQHKKAKVDNDNFSTTNRLNTGFKVNMGQKQWASRFKK
What is the function of this protein?
Has a role in the initiation of DNA replication.  Required at S-phase checkpoint (By similarity).
What are the official names of this protein?
DNA replication regulator SLD2.
What is the protein family that this protein belongs to?
Belongs to the SLD2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.