PharMolix/UniProtQA huggingface dataset:
Protein: TONSL_DANRE
Sequence: MTSTKEIKQLQKAKSKAQSSNNLKEEASLCNQLGEVYAKTGDYQAAIEEHRQELALSEILHDVIGSAVANRKIGECYAELGNIEAALKHQRLHLNLARSVHDAAEEQRALATIGRTYLFLFDSDQSANSLKHAEDAFKRSLAIVDERLEGTVSPREISEMKARLLLNLGCVYDGMKEPQRCSDLIRQSIYIAEKNNLLEDLYRANFNLGSIHFRNGQHSRAMRCFEQSKECARKMKDKFSESECFHSIGKILLHLGDFSAARRSLKKAFCLGSQQPSDREAVKKDFRHAIRGCQLEQTAAEVTQKFSHEALDLSEQLGDLYCKVGCYSKALEAYQTQLACAEALAKPARELAVIHVSLAATYTDLRQHHRAVEHYRQELQLRKGNPKEECETWLNMAVCQEEMCQSMETLDHCFTSALNCAEKSGLNKLQRRVLRVWLQAQRRCGSSQCDDTEARLMELCERDGLSLDQSEDEDEEDEVDNSEPLEDSDIQYSESDDEDLEGYDKMVTGRRKTQRWNRRNEKGETVLHRACIEGNLKQVQYLIEQGHPVNVRDYCGWTPLHESCNYGHQEIVAFLLDRGANVNDPGGRECGGITPLHDTLSCGHFSVARLLVLRGASVTVRNSKGHTPLDTLRQWFKTYSGQLDPETKQECLETEKLIKRALSGDVSVVCAAPRQQKELQDSQLFDAEYSEPLLRESPPSPPPITRPAATVPTSKDSAPKHRSTSASTRRPRGMEVDVLYGDDSSSSDNPDSDCSLSPLRPVRSRPRSPPAQSPQEVPSSQELPSVYGIKETTVPPQSESGRLEYQKAMQNLGSAKSRLFSQSLSDPAFTSTPAVSANSRAALVPEDQYLADDWLEDDLIDMQPKKKRRVSEHNATRETTSRSQNNSSTIAEVPPRVQSCSSRGSLSLKKGSNKPRQVKMNQLPGMVMLGRREVSRSQSPIMTQESDHIQEPAPPSHQAMPPASFQNRAAHVPAPIRMRVKVQDNVFLIPVPHSEADSCTVAWLCDQAAQRYYQMCGLLPRLSLQKEGALLLPTDPLLAVLHTNEEVLAEVCSWDLPPLPERYRKACESLGVEENRRVSRVCEVQDSSSCVSVCGLSLSPASLNPLLRALKLQASLTELRISANRLNDELLPEMMAAAATMPRLRVLDISANQITGEGLRKASDAFETRSQAAFPCLEELNLSMNPLGDGWTQALASLLSSCPLLSSLSLQACGLSARFLQQHRLLLANAMASTGNMRSVCLSHNALGSTGFELVLKTLPMHCLTHLELSAVCRGPSDQPSMEILTKLLAQGDCPLTHLNLSGNGLTDHSVLLLARCLPVCPSLVSLDLSANPLVTSTGLHSLLNGLVEARRPLGHLNLQGCQVSGPLAEDCLDSLSDHIRDLRLCSQSLNKLDQDALQQSWKRRTEAVHIFSRNSKCMLSISSPSH
What is the function of this protein?
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks.  The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication.  It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs.  Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination.  Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones.
What are the official names of this protein?
Tonsoku-like protein, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2.
What is the protein family that this protein belongs to?
Belongs to the Tonsoku family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones: TONSL acts as histone reader that recognizes and binds newly synthesized histones.
Protein: K1PF_ECOL6
Sequence: MSRRVATITLNPAYDLVGFCPEIERGEVNLVKTTGLHAAGKGINVAKVLKDLGIDVTVGGFLGKDNQDGFQQLFSELGIANRFQVVQGRTRINVKLTEKDGEVTDFNFSGFEVTPADWERFVTDSLSWLGQFDMVCVSGSLPSGVSPEAFTDWMTRLRSQCPCIIFDSSREALVAGLKAAPWLVKPNRRELEIWAGRKLPEMKDVIEAAHALREQGIAHVVISLGAEGALWVNASGEWIAKPPSVDVVSTVGAGDSMVGGLIYGLLMRESSEHTLRLATAVAALAVSQSNVGITDRPQLAAMMARVDLQPFN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
What are the official names of this protein?
1-phosphofructokinase, Fructose 1-phosphate kinase, Fru1PK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: NCAP_HAZVJ
Sequence: MENKIVASTKEEFNTWYKQFAEKHKLNNKYTESASFCAEIPQLDTYKYKMELASTDNERDAIYSSALIEATRFCAPIMECAWASCTGTVKRGLEWFDKNKDSDTVKVWDANYQKLRTETPPAEALLAYQKAALNWRKDVGFSIGEYTSILKKAVAAEYKVPGTVINNIKEMLSDMIRRRNRIINGGSDDAPKRGPVGREHLDWCREFASGKFLNAFNPPWGEINKAGKSGYPLLATGLAKLVELEGKDVMDKAKASIAQLEGWVKENKDQVDQDKAEDLLKGVRESYKTALALAKLSNAFRAQGAQIDTVFSSYYWPWKAGVTPVTFPSVSQFLFELGKNPKGQKKMQKALINTPLKWGKRLIELFADNDFTENRIYMHPCVLTSGRMSELGISFGAVPVTSPDDAAQGSGHTKAVLNYKTKTEVGNPCACIISSLFEIQKAGYDIESMDIVASEHLLHQSLVGKRSPFQNAYLIKGNATNINII
What is the function of this protein?
Binds dsRNA and ssRNA and probably participates in the packaging of viral genome (By similarity).  In the dsRNA binding mode, the nucleocapsid protein specifically binds to the vRNA panhandle secondary structure formed at the termini of viral genome (By similarity).  Does not discriminate between viral and nonviral RNAs through ssRNA binding mode (By similarity).  Displays dsDNA endonuclease activity that is sequence non-specific (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the nairovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Internal protein of virus particle.
Protein: HSLV_BUCAI
Sequence: MTTILSVRLKNKVVIGGDGQATLGNTIMKSNVKKIRSLYHEKVIAGFAGGTADAFTLFEMFDKKLAMYQGQLQRAAIELAKDWRSDRMLRKLEALLAVADKKTSLIITGNGDVIQPEDDLIAIGSGGSYAQSSARALIENTHLDANQIVRKSLNIAANICIYTNHNFTIKELFSEK
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FURA_MYCBO
Sequence: MSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFGAVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIADVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP
What is the function of this protein?
Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner.
What are the official names of this protein?
Transcriptional regulator FurA.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTAP_COPC7
Sequence: MSEENVLIGVIGGSGLYQLDNLTVVKTVNPETPWGFPSSPITIAALPSGTKVAFLARHGIGHVIPPSSVPSTANIAALKSLGVSAILSFSAVGSLREEISPGSFALPSQIIDRTKGIRDSSFFNGTSIVAHAMFGDPFSNKLIRWLEPRVRKALEKEGKGKLLFTDKTIVCMEGPQFSTRAESVMYRQWGGDLINMSVLPEAKLAREAELSYALIAMATDYDSWRPHSDAVTAHDVVQTLHDNGASAKLVLSTILDDLHTTINTHHRALTNGNSQDLEAIREEEALLQERGSMKFSIMPASPQQKAEDRKKLAFILPEHFKDAA
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MTC7_YEAST
Sequence: MKKEKKTPTPLPSHHVLFAEPGFFLCNFFFVLLKHTQINPFFYFLFILLFIIYIAIIYFVFIRISHFSFSLCRQCNSLGRMIFMCAYLPAASSRSVANPALPPQKKKKKKKKGTLRTGEVEEQAKGNISFDLCGKQNFQ
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 7.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COAX_DEIRA
Sequence: MPAFPLLAVDIGNTTTVLGLADASGALTHTWRIRTNREMLPDDLALQLHGLFTLAGAPIPRAAVLSSVAPPVGENYALALKRHFMIDAFAVSAENLPDVTVELDTPGSVGADRLCNLFGAEKYLGGLDYAVVVDFGTSTNFDVVGRGRRFLGGILATGAQVSADALFARAAKLPRITLQAPETAIGKNTVHALQSGLVFGYAEMVDGLLRRIRAELPGEAVAVATGGFSRTVQGICQEIDYYDETLTLRGLVELWASRSEVR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Q0017_YEAST
Sequence: MCATYMFNITVIITHPTPTLRTRGPGFVRNRDLYIYKYKSNLINNLNNMTYIL
What are the official names of this protein?
Putative uncharacterized protein Q0017, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DER_BURM9
Sequence: MKPVIALVGRPNVGKSTLFNRLTRSRDALVADLPGLTRDRHYGEGRVGARPYLVVDTGGFEPVAKDGILHEMARQTRQAVEEADVVVFIVDGRNGLAPQDKSIADYLRKTGRPIFLVVNKAEGMKYTAVASDFYELGLGDPRAISAAHGDGVNDMINEALEVAYAGEPQESEEAAAARGIKIAIVGRPNVGKSTLVNTLIGEDRVIAFDMPGTTRDSIYVDFERNGKHYTLIDTAGLRRRGKVFEAIEKFSVVKTLQSISDANVVILLLDARQDISDQDAHIAGFVVEQGRALVVGVNKWDGLDPHVRERTKADLARKLKFLEFAKFHFISAAEKTGIGALMRSVDDAYAAAMKKLPTPKLTRALIEAVEFQQPRRRGPVRPKLRYAHQGGQNPPIIVIHGNALDAVTETYKRYLENRFRETFSLTGTPLRIEFRSSTNPYADKD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: AIM46_YEAS1
Sequence: MRLISKVLVKTNCLEVGMRRAPQWYSHYSTTAGNARVNKKGSKVVPVLTGLALASIFAKKWYDDSQIKKADATSVAVDASISAFPKKMGPPQWPFSTQYELIGKGVRCVSSITFKAYGLGIYVAAEDKHLVSEVLDSKFLSQAFIDTAAPPSPENSHQDNLRAALNDPAKAPILINNLLDSGIRLMSKNTPIKAGSFKLLMDGTKKSVLKNPDSQSQDKDRLEAGFQELHDCFRSVKGLVARDDDFFIELNKDCSMNLSYYARKKDEFVILGTVKEPLIGKLLFAHYLAAVDPPSPEARKEVIDALVSLS
What are the official names of this protein?
Altered inheritance of mitochondria protein 46, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM18/AIM46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUOK_MYCBP
Sequence: MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAFVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GMAS_METUF
Sequence: MSPSEAQQFLKENQVKYILAQFVDIHGSAKTKSVPAEHYKTVVTDGAGFAGFAIWGMGMTPNVDADYMAVGDASTLSLVPWQPGYARIACDGHTHGKPHEYDTRVVLKKQLEQITARGWTFFTGMEPEFSLLRKVEGKLLPADPGDTLSKPCYDYKGLSRARVFLERLSESLRSVGIDVYQIDHEDANGQFEINYTFTDALTSCDHYTFFKMGAAEIAAELGLICSFMPKPFSNRPGNGLHMHMSIGDGKRNLFEDKSDKHGLALSKLAYHWAAGLLKHAPALAALCCPTVNSYKRLVVGRSLTGATWAPAYICYGGNNRSGMIRSPGGRLELRLPDASCNAYLATAAVIAAGMDGVINELDPGAPQNDNLYEYSQAQLDAAGIKVLPQNLHEALLALEKDEVIRSALGPVVDEFLRLKHMEWVEYMRHVSDWEVNSYLEFF
What is the function of this protein?
Catalyzes the formation of N(5)-methyl-L-glutamine from glutamate and methylamine.
What are the official names of this protein?
Glutamate--methylamine ligase, Gamma-glutamylmethylamide synthetase, GMAS.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family. Type 3 subfamily.
Protein: HTAI2_PONPY
Sequence: MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRVKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGYSVPVVTVVRAMLNNMVRPRDKQMELLENKAIHDLGKVHGSLKP
What is the function of this protein?
Oxidoreductase required for tumor suppression.  NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors.  May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity).
What are the official names of this protein?
Oxidoreductase HTATIP2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope.
Protein: ARGB_PSEPK
Sequence: MTLDRDAASHVAEVLSEALPYIRRFVGKTLVIKYGGNAMESEELKTGFARDIVLMKAVGINPVVVHGGGPQIGDLLKRLSIESHFIDGMRVTDSATMDVVEMVLGGQVNKDIVNLINRHGGSAIGLTGKDAELIRARKLTVSRQTPEMTTPEIIDIGHVGEVVSVNTDLLNMLVKGDFIPVIAPIGVGANGESYNINADLVAGKVAEALKAEKLMLLTNIAGLMDKQGQVLTGLTTEQVNELIADGTIYGGMLPKIKCALDAVQGGVNSSHIIDGRVPNAVLLEIFTDSGVGTLITNRKPR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_XANP2
Sequence: MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHSAVNVDDADVVVVSSAIKRDNPELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTTTTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMVVEADESDGTFLKLPTEVAIVTNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGENPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHELKVPDDKIIEAIANFGGVKRRFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVIAVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETPIEGADRDHLVQGLIAHGHRSVTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK2_SHESR
Sequence: MKIGILSQFPELYSTRRLVAACESRGHEAVVINTLNCYMNINSIKPSIHYQGQELTGFDAIIPRIHASVTFYGCAVVRQFEMMGVFAANDSISIARSRDKLRALQLLSRKGIGMPVTGFANKPNDIPDLINMVGGAPLVIKLLEGTQGIGVVLAETKTAAESVIEAFLGLKANIMVQEYIKESNGSDIRCFVVGDKVVASMKRQGPEGDFRSNLHLGGCGEKVKITPEERKMAVAAVKAMGLVVAGVDILRSNRGPLILEVNSAPGIEGIEQTTGISVTEPIVEYIEKMVLARKSNRAVIA
What are the official names of this protein?
Probable alpha-L-glutamate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: UVSE_BACMK
Sequence: MIIRFGYVSHATALWDCSPAKTMTFTSWKKLKKQEREDKLYNVTLQNLEHTIRILHYNIAHEIPLYRLSSSIVPLATHPEVEFDYIQIFAPLWRKIGALIQEHNLRVSFHPNQFTLFTSDKPHITTNAITDMTYHYNVLNAMGIADSSYINIHVGGAYGNKEKAIERFHENIQKLPYHIKRQMTLENDDKTYTTSETLAICQKEKIPFVFDYHHHIANLCNEPLEELLPMIFKTWSHTNVLPKVHISSPRSEKEFRAHADYIDLEFIKPFLHITKKINHNFDIMIESKQKDLAMLQLICELSSIRGIKRINSATLQW
What is the function of this protein?
Component in a DNA repair pathway.  Removal of UV LIGHT damaged nucleotides.  Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion (By similarity).
What are the official names of this protein?
UV DNA damage endonuclease, UV-endonuclease, UVED.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: RS4_ACHLI
Sequence: MSRFTGSTWKVSRRLGYSISETGKELKKRPYAPGQHGQRRSKLSNYGIQLQEKQKVRFVYGVSEKQFKKTFLESAKMQGKQGENFLKLLESRLDNVVYRLGFTKTRAQARQLVNHGHILVDGKKVDIPSYRLAPGQTVQLKEKSKNLTIVKEALEAQFAHVDYVALDANGVGTFSRLPERNEFLFDINEQLIVEFYNR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: Y236_ARCFU
Sequence: MVIAAMLVPFVAIRSHDMTTYLYWTAVTAAYLTYLTIKRW
What are the official names of this protein?
Uncharacterized protein AF_0236.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS6_MYCGE
Sequence: MHYNIILLVDGTLSLEQANQVEQKHQKLLEKATEFKSEYLGLKELAYPIKKQLSAHYYRWSFHGESNCTKEFKRAANINKQIIRELIINREKDYGYLGSVNPKKQQLSLQKLTKYNEIIASENNPDNPDAPVTSGLASVKPRLSRVEKQKERELEKWTVVHQSGNFDTVQINPYRPRIKRFLQNNQQTSQANNNQPRFQNQFKKGAKP
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RL15_UREU1
Sequence: MQLHNLEYKKGSRNHKEKRVGRGHGSGLGKTSGRGQDGQKARKSGMVRLAFEGGQTPLYRRVPKVGFNNDRFANKYNVVTLISLVKYETKELTAEFMYVNKIAKNEDLPIKVIGNAVLPSGTVVSAHKFSKGALESISNSKAKAQILE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DMTA2_TAKRU
Sequence: MAGNLLRGPPLLLRASDKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEVRELQLLYGTAEGLALAAANGIIPPRPNYEVFGSVSSESNSDSSVQKFETFSKGQLSGPTTPQQAAGKSASAESDSAPGMSSPDGRHGGSGSENGDSESFINSPVSKPLKDGGETPGSVSSIGSDSGSETDKDEQEPSPSSAASRHMNAIDILTRVFPSHKRSILELVLQGCGKDVVQAIEQILNNSGAQGSNKAGPDEGWTAERMLQGAQQPPPPPAASTAPTRPLLPGAMTLSNRSAFSPLQPNTPHFGADPSTYPLGTHLGLNPLRLAYSAHGRGLAFMTPYSTTGLMPTLGFRPPMDYAFSDLIRDRTMLHKEQGYSGGLYGPLVNNTTEKQ
What is the function of this protein?
May be involved in sexual development.
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor A2, Doublesex- and mab-3-related transcription factor 5.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RP54_KLEOX
Sequence: MKQGLQLRLSQQLAMTPQLQQAIRLLQLSTLELQQELQQALDSNPLLEQTDLHDEVETKEAEDRESLDTVDALEQKEMPEELPLDASWDEIYTAGTPSGNGVDYQDDELPVYQGETTQSLQDYLMWQVELTPFTDTDRAIATSIVDAVDDTGYLTISVEDIVESIGDDEIGLEEVEAVLKRIQRFDPVGVAAKDLRDCLLVQLSQFAKETPWIEEARLIISDHLDLLANHDFRSLMRVTRLKEEVLKEAVNLIQSLDPRPGQSIQTGEPEYVIPDVLVRKVNDRWVVELNSDSLPRLKINQQYAAMGNSTRNDADGQFIRSNLQEARWLIKSLESRNDTLLRVSRCIVEQQQAFFEQGEEFMKPMVLADIAQAVEMHESTISRVTTQKYLHSPRGIFELKYFFSSHVNTEGGGEASSTAIRALVKKLIAAENPAKPLSDSKLTTMLSDQGIMVARRTVAKYRESLSIPPSNQRKQLV
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the nitrogen fixation genes.  The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: REV_HV1H3
Sequence: MAGRSGDSDEDLLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: TTCA_YERP3
Sequence: MLEKQSVNQKEQYNFNKLQKRLRRNVGQAIADFNMIEEGDRVMVCLSGGKDSYTMLDILQSLQKSAPINFSLIAVNLDQKQPGFPEDILPAYLDKQGVEYKIVEENTYGIVKEIIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKLKGMPPKLMSDDGKHIVIRPLAYCREKDIERFAVAREYPIIPCNLCGSQPNLQRQVIKDMLRDWDKQYPGRIETMFSAMQNVVPSHLNDHKLFDFKSITHDSDIIDGGDLAFDREALPLNPVGWQPEDDEDTEKRPPVRLDVLEIK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_MYCSJ
Sequence: MARYTGPATRKSRRLGVDLVGGDQSFEKRPYPPGQHGRARIKESEYRTQLQEKQKARFTYGVLEKQFRRYYDEANRQPGKTGDNLLRILESRLDNVVYRAGLARTRRMARQLVSHGHFTVNGVKVDIPSYRVSQYDIIDVREKSLNTDPFVIARETAGDRPIPSWLQVVGERQRILVHQLPERAQIDVPLTEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NUOI_SYNC1
Sequence: MSLWKDIKGTILPFWVTLRYLFRRPVTVCYPERKQTPAPRYRGRLVLTRDPDGEERCVACHLCSAACPVDCISMQAAEREDGRRYAAWFRINFSRCIFCGLCTEACPTLALQMTSEYELATRELLQVIYEKDELLIDGCGKNAEYNFYRRAGIGVVAPRGANPGESSPEDVKSNLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YAII_SALPB
Sequence: MTIWVDADACPNVIKEILYRAAERMQLPLILVANQALRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEVLEKGAAALNPRGERYSDATIRERLTMRDFMDTLRASGVQTGGPNTLSPRDRQHFAAELDKWWLENQRKK
What are the official names of this protein?
UPF0178 protein YaiI.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.