PharMolix/UniProtQA huggingface dataset:
Protein: CMTA1_HUMAN
Sequence: MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT
What is the function of this protein?
Transcriptional activator.
What are the official names of this protein?
Calmodulin-binding transcription activator 1.
What is the protein family that this protein belongs to?
Belongs to the CAMTA family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: YNJ5_YEAST
Sequence: MVHITLGQAIWVSVKPIIKIYLIIGVGFLMAKMGILTVEATRIISDIVLTVLLPSLSFNKIVANIEDKDIKSVGIICLSALLIFGSGFFFAYVVRLFLPVPKQWYGGILAGGMFPNISDLPIAYLQSMDQGLVFSEEEGNKGVANVIIFLTMFLICIFNLGGFRLIESDFEYNDDESAVRVSETTKTQPAVSANTTNTDTSERFFSNEQQLFNNKYTARDSLTEAIGTKGENADVPPISRRSTNSIAPLSLPDTSSNSKITKPVQVKARNTIACTQSEESQATRGSNPLDSQSSASTIHSYNTSESYESSIDTMRARRTASQPRAYNTTTLLEENCLDEKCPKNMSMAALEPIRSIDMRALPSQNIHHLIREYSNVDQYGHQRRNSSLRGADMNDVHSISSNSTLQTIKTANLTRILTSDATVSKKDIETSGESLPQWMRKFSLTPLLVFFLKNCLRPCSMAVIIALTVAFIPWVKALFVTTANTPHISQAPDNAPPLSFFMDFTGYVGAACVPFGLILLGATLGRLKIGNLYPGFWKAAVTLVILRQCVMPIFGVLWCDRLVKAGWVNWQDDRMLLFVIAISWNLPTMTTLIYFTASFTPPETTAPIQMECVSFFLMLQYPLMVVSLPFLVSYFLKVQMNL
What are the official names of this protein?
Uncharacterized transporter YNL095C.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNPA_ACIAD
Sequence: MMTLYSFSTEVRLRCAADYQGVFDGALFKVHQPHFLFLAKPSEQLQSRLGVIVAKKKVRRAHERNRIKRLARESFRLHQQQLGLLDIVVMPKIGIEAVSNADLHQQLEFAWQKLQRQAKKYQKVAVSPSLH
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RS8_BLOFL
Sequence: MSMQDPIADMLTVIRNGQVAKKDKVYVPSSTIKIAITKVLVEEGFLKDYSVLGNIKFILEISLKYYQCNKPVIDHIQRISRPSLRVYKNKDMLPKVLSGMGVVVVSTSKGVMTDKKARKLNVGGEIICYVS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y063_RICFE
Sequence: MKELIEFLEKTGLKTEADSLRNGGTELNPQSNIGTLGAKKLAAALKDNKSLKYLNLIGSYIGEEGARALAEALKDNESLKELYLTPADISTVTLNRIKEYIQRNTDLYYKEQQQYNKQLISSIKANEIKQAESIIPFIDPKYSNSVDENNNTALHYAVDKNLEKLSISLINKMSIETISIGNMYNNTALHYATDNGLEVISWFLINNMTQKALDMVNTDGNTALDYAIHNRHLL
What are the official names of this protein?
Putative ankyrin repeat protein RF_0063.
Protein: SYH_BURM7
Sequence: MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSRAHFDGLQQLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_BACCR
Sequence: MQQKTDVILIGAGIMSATLGSLLKELAPEWEIKVFEKLASAGEESSNEWNNAGTGHSALCELNYTSEKADGSIDISKAVKVNEQFQLSRQFWAYLVKSKLIRNPQDFIMPLPHMSLVQGKKNVEFLKNRFEALSKNPLFQGMEFSDAPETLKKWLPLIMEGRTSNEPMAATKIDSGTDVNFGALTRMLFDYLKTKNVELNYKHSVENIKRTKNGLWEVKVHDMNSGKIEHHTAKFVFIGGGGGSLPLLQKTGIPESKHIGGFPVSGLFMVCKNQKVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKALLFGPFAGFSPKFLKTGSNLDLIGSVKPNNVLTMLAAGVKEMGLTKYLIQQVMLSHEKRMLDFPAFIPNAKSEDWDIVVAGQRVQVIKDTDAGGKGTLQFGTEVVSAADGSIAALLGASPGASTAVHVMLEVLEKCFPSRMIEWEEKIKEMIPSYGISLTENPRLFQDLHTSTGRTLGLNEKETVHN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: RDRP_I78A8
Sequence: MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQKQ
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: GET1_BOTFB
Sequence: MPSLLFTCFLVQLLIHLVNTFGADAINNLLWNLYNMFPTPTSQSAGEQKKLKREFMKVRHEMNATSSQDEFAKWAKLRRQHDKLFDQLEKSKSSLDSTKSTFDSSVSTLRWLGTNGLRMLLQFWFSKQAMFWLPKGWFPYYAEWLLSFPRAPLGSISIQAWTLACAAVILLVSDALVAVVALALGTQTGAKAKKMEEPMKAGGQGTEKPGKKEL
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein get1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NOC_HALH5
Sequence: MKQPFSRLFGFGDKQDQEMETGKQEEVHQLPIKEIVPNRFQPRTIFDDERIEELAQTIRTHGIIQPIVVRQREGKYEIIAGERRFRAVTLLGWETIPAIIKEFNDSQTASVALIENLQREGLTAVEEAVAYQKLIELHGLTQESLAQRLGKGQSTIANKLRLLHLSEPVQQAIMERKISERHARALLSLKDDALETKLLEEIVEQHLNVKQTEERVKELLEDAPASKPKKKPTRKAYSKDMRIAMNTIRQSVDMVMKSGLKVDTAEEEHEDFYQFTIRIPKKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: H2B_PATPE
Sequence: MPPKPSGKGQKKAGKAKGAPSTNKKRKRKRKESYGIYIYKVMKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKKSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYE_BRASB
Sequence: MTSPIVTRFAPSPTGFLHIGGARTALFNWLYARGRCGKMLLRIEDTDRERSTTAAIDAILDGLKWLELDWDGEVIYQYSRAARHREVAEQLLASGMAYRCYATAEELAAMREKARAEGRTRLYDGMWRDRDPKDAPGDVKPTIRLRAPLTGETVIEDQVQGRVVWQNENLDDLVLLRGDGNPTYMLAVVVDDHDMGVTHVIRGDDHLINAARQKQIYDALGWTVPSMSHIPLIHGPDGSKLSKRHGALGVDAYRAMGYLPSALRNYLVRLGWSHGDQEIFSTEEMIKAFDLPAIGRSAARFDFAKLENLNGHYIRHSDDAALVRQFEDVLNYVPNGATLKAKLNDATRAQLTQAMPSLKERAKTLLELIDGAAFLFADRPLPIDAKAAALLTPDSRALIGRLHDALAAVEPWSGPATEAALRAFAETNNLKLGAVAQPLRAALTGRTTSPGIFDVLAILGRDESLGRLKDQTTS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_METJA
Sequence: MIVLTIEEILKEVLNEIKPSKEDMEKLQLKANEIIDKIWEIVRENSYPILEVLLVGSSARNTNLKDDYDIDIFVLFDKSVSEDELEEIGLKIGTEAIKRLNGSYNINYASHPYVNGEVDGYEVDIVPCYKIDFGEKIISAVDRTPLHHKFLISRLNERLCDEVRLLKAFLKSLGLYGSDVKTKGFSGYLCELLILHYGSFINLLKEAQNWRIGKKIILKDIFEIYKDVDINKLKKFDEPFIVYDPVDLNRNVASPLSKDNFCRFIFYSRQFLKNPSIEFFKDYAKKLEEILENREHGYRLILKIPRENVVDDIIYPQMEKLQKSINKVIVKNEFVILNSKCFADDNYCYLYWEFLVYELPKIALREGPPVFEKERAERFLKKYGKVFIRDCKLFAYTEREYSHIIDLFKDIVNGNLQNISIPKYVNPRNGKIIELNSHGEHKQFNKECQ
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: AROB_FRATT
Sequence: MISKLSVNPTFSPSYNIIVDSVLDFSHILEYVTNKQVLVVTNTTVAKLYLTKFLAALVDDLDVRTCILEDGEQYKSQQSLDKILSTLLENHFTRNSTVLVALGGGVIGDITGFAAAIYQRGIDFIQIPTTLLSQVDSSVGGKTAINHQLGKNMIGAFYQPKVVYTSIEFYKTLPQREYIAGMAEVVKYAFISKDFYLWLDSNRDKILAKDSVTLIEMVKRSCQIKAQVVAMDEKELTGARAILNFGHTFGHAIEKCQNYRGLKHGEAVGVGMAQAIDFSHYLGLISQQQAKDFNDFIVSFGISIDFPNDICQKEFLEAMLLDKKNSNKELKFILIENIGSLSLQKQSKNELEQFLDISR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_SHESM
Sequence: MQPFTSHTGLAVMIDSANIDTDQIIPKQFLSKVTRDGFGVHLFHDWRYLDDAGDVPNPDFTLNKPRYSGASILLAQENFGCGSSREHAPWALADFGLRAIIAPSFADIFYGNSINNGLLPVKLSANEVRQLMDEVASEEGAQITVDLTTCKVISPSGAEFSFTLAESARHKLLNGLDAIGLTLSHGTQIGEYEANIPSWRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: PRS44_MOUSE
Sequence: MAFQGCDCFGLLVWLLLLQTRLGKARMVPGTPSLSPLPSENGLDDSGVNPQERPLTGMPETSLPRKPGDSTRPLDSMAFTPGQSFSTMSLSRQPFPTWVPPTSACGHRTARIVGGRPAPARKWPWQVSLQVHKQHICGGSLISKWWVITAAHCVYGHLDYAVFMGDADLWSKRPVRIPVQDIIVHQDFSMMRTVVHDIALVLLAFPVNYSVNIQPVCIPEKSFLVQPGTLCWVTGWGKVLEQGRSSRILQEIELNIIRHEKCNQILKDIMGNIFTLVQEGGVCGYNEKGGDACQGDSGGPLVCEFNKTWVQVGIVSWGLGCGRIGYPGVYTEVSYYRDWIIKELSRASCWKLSGFLVLSVCLVLHLAIVVAL
What are the official names of this protein?
Serine protease 44, Testis serine protease 4, TESSP-4, Testis-specific serine protease 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm.
Protein: Y599_STAAR
Sequence: MKNTFLICDECQAVNIRTLQKKLEKLDPDAEIVIGCQSYCGPGRRKTFAFVNNRPLAALTEEELIEKVSQQLKKPRDPEEEERLRKRHEERKRRKEEQDRKLKEKLEKRKAQQ
What are the official names of this protein?
UPF0741 protein SAR0599.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: RALB_RAT
Sequence: MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKSGKSKKSFKERCCLL
What is the function of this protein?
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking.  Accomplishes its multiple functions by interacting with distinct downstream effectors.  Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (PubMed:17202486).  Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (PubMed:16382162).  Required for suppression of apoptosis (By similarity).  In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity).  Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
What are the official names of this protein?
Ras-related protein Ral-B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody.
Protein: NREC_STAAN
Sequence: MKIVIADDHAVVRTGFSMILNYQNDMEVVATAADGVEAYQKVMEYKPDVLLMDLSMPPGESGLIATSKIADSFPETKILILTMFDDEEYLFHVLRNGAKGYILKNAPDEQLLLAIRTVYKGETYVDMKLTTSLVNEFVSNSNQDTANTTDPFKILSKRELEILPLIAKGYGNKEIAEKLFVSVKTVEAHKTHIMTKLGLKSKPELVEYALKKKLLEF
What is the function of this protein?
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen.  Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).
What are the official names of this protein?
Oxygen regulatory protein NreC, Nitrogen regulation protein C.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PARD8
Sequence: MKEKISNNIQIKNKRATFDYELLDTFTAGIVLTGTEIKSIRLGKASLVDTFCIVEKGELWVKNMYIAEYFYGTYNNHNARRDRKLLLTKKELRKIEGAVRASGFTIVPTRLFINEKGLAKVVVAIARGKKEYDKRDSIRERDDRREMDRAFKR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MALT1_HUMAN
Sequence: MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
What is the function of this protein?
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955).  Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101).  Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101).  Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity).  Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753).  May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475).
What are the official names of this protein?
Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: COG6_SCHPO
Sequence: MDVKSKHGHIKSNPEESLLFRNSVSKNIAQLSSINYADRNVQAALEQLSERKFKNEREARKQLPFEVFSDLIWTNGSIIKELSELSSQTLSVQSQLLKVKNSIDSYKNEWSKKTNDAQILLNSYETFCEEEALIEEKLKNIEIFEKNFVIMDDDLIHLTSSTDVDDRFYLILDKAQEIHDSSDSLFASLSGFVEYSSFEEIVKKMSRYIEAAFEKLFRCVQTELSDPQTAQTLEANSHLKKAFTKLFSEPTMVNKSINLIVQARQQILSTAYLTALTRGDFLSSSRPIELSAPDTVRFIGDLLAWIHQTIVNEKELVEALFAARKRQIQLNPFPPWDVPNVLEDQMNSLLDGSLYGICRPLSSRAQTSVLDLSDIVRLYNVIEILGFYREAFSKIVHDECIILRIIKTLEDFTYQRMKTVLDDELYTISNTNLSITDDLLPPDFVTTFLRNANSIFKIRGASLSVQGVDELPFKMLFMQLFDRILEICAAMTEDVRPPYKGIILMLNVLDSCTNYVGRYTFLNELFEYLQEKTTYYKNNLTTLLNNDYIAQAGLSDLLQKIADTTDDKQALKNYLHSWKWDQQIDKFSTFIRKTLSETIDNLQLLTSPIVTNQVLKETAISFVGAIETVDKALELSNLERRWPLSTEELLIAMNVDSMDTLSDIGQSDIDNLSVN
What is the function of this protein?
Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking.  COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes at the barrier septum.
Protein: G6PI_LIMFE
Sequence: METLSFDSSALKKFVHPNELGEMQAMVTAADSELRNGTGAGADFRDWLHLPTDYDKDEFARIEAAAKKIQADSEVLVVIGIGGSYLGARMAVDFLHHSFYQAQTAADRKQPLVLFAGNSLSSSYIADLIDVIGDRDFSVNVISKSGTTTEPSIAFRVFRQLLEDKYGVDGANARIYATTDRQRGALKTEADAEGWGTFVIPDGVGGRFSVLTAVGLLPIAVSGADIDQLMAGAAKAEATYVNPDLTQNEAYQYAAYRNILYRKGYTTELLENYEPNMTMLAEWWKQLAGESEGKDQKGIYPSSANFTTDLHSLGQYIQEGRRNLMETVVKLAEPNHNVKVPSAKSDFDGLKYLEGKEIDWVNTQAYRAVVAAHTTGGVPVMTVNIAKEDEFTLGYLIYFFEVAIAISGYLNGINPFNQPGVEAYKTNMFGLLGKPGFEEIGEQLKKEMDD
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPQ_BACVZ
Sequence: MSSFHATTIFAVQHNGKSAMSGDGQVTFGQAVVMKHTARKVRKLFNGKVLAGFAGSVADAFTLFEMFEAKLEEYNGNLKRASVELAKEWRSDKVLRKLEAMLIVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALSAGRALKTYAGENLSAKDIAKAALKIAGEICVYTNDQIILEELE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex.
What are the official names of this protein?
ATP-dependent protease subunit ClpQ.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.