PharMolix/UniProtQA huggingface dataset:
Protein: BIOC_PECAS
Sequence: MLTENYNKQAIAQAFGRAAGCYDRFAELQRTSGERLLALMPAHSGLQVLDAGCGTGHFSRYWRQAGRNVTALDLSAEMLAYAREQHAADRYLEGDIENLPLADSCVDICYSNLAVQWCDSLPRALGELYRITRPGGVIAFATLADGSLSELSQAWQRLDGTQRTNRFLPHSVIDAACQPYRHHLLQEREVCLFPDVLALMKSLKGIGATWLHEGRTPGLLSRARLAALSACYPQEQGGYPLSYQLVYGVIYRD
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: AB32G_ARATH
Sequence: MWNSAENAFSRSTSFKDEIEDEEELRWAALQRLPTYSRIRRGIFRDMVGEPKEIQIGNLEASEQRLLLDRLVNSVENDPEQFFARVRKRFDAVDLKFPKIEVRFQNLMVESFVHVGSRALPTIPNFIINMAEGLLRNIHVIGGKRNKLTILDGISGVIRPSRLTLLLGPPSSGKTTLLLALAGRLGTNLQTSGKITYNGYDLKEIIAPRTSAYVSQQDWHVAEMTVRQTLEFAGRCQGVGFKYDMLLELARREKLAGIVPDEDLDIFMKSLALGGMETSLVVEYVMKILGLDTCADTLVGDEMIKGISGGQKKRLTTGELLVGPARVLFMDEISNGLDSSTTHQIIMYMRHSTHALEGTTVISLLQPSPETYELFDDVILMSEGQIIYQGPRDEVLDFFSSLGFTCPDRKNVADFLQEVTSKKDQQQYWSVPFRPYRYVPPGKFAEAFRSYPTGKKLAKKLEVPFDKRFNHSAALSTSQYGVKKSELLKINFAWQKQLMKQNAFIYVFKFVQLLLVALITMTVFCRTTMHHNTIDDGNIYLGSLYFSMVIILFNGFTEVPMLVAKLPVLYKHRDLHFYPSWAYTLPSWLLSIPTSIIESATWVAVTYYTIGYDPLFSRFLQQFLLYFSLHQMSLGLFRVMGSLGRHMIVANTFGSFAMLVVMTLGGFIISRDSIPSWWIWGYWISPLMYAQNAASVNEFLGHNWQKTAGNHTSDSLGLALLKERSLFSGNYWYWIGVAALLGYTVLFNILFTLFLAHLNPWGKFQAVVSREELDEREKKRKGDEFVVELREYLQHSGSIHGKYFKNRGMVLPFQPLSLSFSNINYYVDVPLGLKEQGILEDRLQLLVNITGAFRPGVLTALVGVSGAGKTTLMDVLAGRKTGGTIEGDVYISGFPKRQETFARISGYCEQNDVHSPCLTVVESLLFSACLRLPADIDSETQRAFVHEVMELVELTSLSGALVGLPGVDGLSTEQRKRLTIAVELVANPSIVFMDEPTSGLDARAAAIVMRTVRNIVNTGRTIVCTIHQPSIDIFESFDELLFMKRGGELIYAGPLGQKSCELIKYFESIEGVQKIKPGHNPAAWMLDVTASTEEHRLGVDFAEIYRNSNLCQRNKELIEVLSKPSNIAKEIEFPTRYSQSLYSQFVACLWKQNLSYWRNPQYTAVRFFYTVVISLMLGTICWKFGSKRDTQQQLFNAMGSMYAAVLFIGITNATAAQPVVSIERFVSYRERAAGMYSALPFAFAQVFIEFPYVLAQSTIYSTIFYAMAAFEWSAVKFLWYLFFMYFSIMYFTFYGMMTTAITPNHNVASIIAAPFYMLWNLFSGFMIPYKRIPLWWRWYYWANPVAWTLYGLLVSQYGDDERSVKLSDGIHQVMVKQLLEDVMGYKHDFLGVSAIMVVAFCVFFSLVFAFAIKAFNFQRR
What is the function of this protein?
May be a general defense protein (By similarity).  Required for the formation of the cuticle layer of the cell wall (PubMed:21628525).
What are the official names of this protein?
ABC transporter G family member 32, ABC transporter ABCG.32, AtABCG32, Pleiotropic drug resistance protein 4, Protein PERMEABLE CUTICLE 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PEPQ_CROS8
Sequence: MDSLTTLYKNHLDTLQERTRNVLARFNLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPSAFWTEEIDIIALPKADDIGGQLPAARGNIAYIGPVPERALKLDVPADKINPKGVIDYLHFYRAYKTDYELACMREAQKTAVNGHRAAHEAFLSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTRLDHRAPSEMRSFLLDAGAEYNGYAADLTRTWAADGDSDFAALIKDVNEEQLALIGTMKAGVSYIDYHIQFHQRIAKLLRRHQIVTDISEEAMVEADITGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHLAAPAKYPYLRCTRVLQPRMVLTIEPGIYFIESLLVPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHEHGVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: RL4_XANCB
Sequence: MELVITGSNNKVSVSDAVFGREFSEDLVHQVVVAYRNAGRAGTKAQKTRSEVAGTTKKSKKQKGGGARHGALTAPIFVGGGVTFAAKPRSFEQKVNRKMYRAAICAIFSELNRQGRLMIVDSFDIEATKTKGLIEKLKGMDVGKRPLIVTEEASEHLYLSARNLPYVQVRDVQGLDPVALVGADTVVITADAVKKVEEWLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PUR71_BRADU
Sequence: MSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQHLNDIGVPTHFIRRLNMREQLIREVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEFYYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDFLTGLFLGIGIRLVDFKMECGRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILMENERPAGSGPVLVKS
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase A, SAICAR synthetase A.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DDL_STRP4
Sequence: MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFTVKTFFISQSGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSVQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEVEEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVGLLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFRAIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDLAKESFDKREAHLI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_CLOBJ
Sequence: MAKIRVYELAKELNISSKELITLLEEEFSVEVKNHMSAIEDEDANLIKELLSGKEKSEKTKEEDDEIETTAKNPIKESMNNKKSNKRDDKNEKVNTENAEDMGIITMTSDTITVKEISDKLEKSYAEVIKELMLMGVMASVNQEINFEMAEKLAAKFDMEILKEDEDEKEDLEDILKDNEEEEYLQKRSPIITVMGHVDHGKTSLLDAIRKSKITSTEAGGITQHIGAYTVELNGEAITFLDTPGHAAFTAMRARGAQVTDIVILVVAADDGIMPQTQEAISHCKAANVPLIVAINKIDRPGANIDKVKQELTEYGLVAEDWGGDTICVPVSAHTKEGIDDLLEMILLSSEILELKANPNRKAKGTVVEAKLDKGRGPVATLLIQNGTLRVGDSIVVGSTYGRIRAMFNDKGRNIESAGPSTPVEILGLSEVPEAGDKFYQVKEEKTARGIADKRKEKIRDEYLQSTHKVSLEDLYNQIQEGTVKELGLIVKADVQGSVEALKQSLEKLSTEEVKVRVIHGGVGAINETDVTLATASNGIILGFNVRPDNNAIIASERDGVDIKTYRVIYDAIEDIKSAMLGMLEPEFKEVVIGTAEVRQVYKISSVGTIAGAYIQTGKLARNAGARVIRDGIVIFESELASLKRFKDDAKEVAQGYECGLSIEKFNDIKEGDIIECFIMEEIKKKTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCY10_CAEEL
Sequence: MLKSLLIIVIVFLHRELCDGIQLILFDNWPSAQNVCASAVADATANGQCTTKSIQKHLELLTVIILLKLFGVFHRINQQHGCSGDNSVKSASYAINAVASRTSGELDFVFVGPTCTTDIRTIGDFAEIWKSPVIGYEPVFEARGVQELTSVINVAQFSVGGVAETLVFLMKELEQVEITLVGSVKVLPNGLSLSNDLRSYNEIMNSFKIREYVEVDENDVDWTKVDQKIKRGARMIVVCADFYDIYSAFYNIGIRSLSGFRFIIVVILNKPPDEILNQPNVKNLLYGSNAFIISPLQEQYSDAFSIMQDVIPNLADDQFTTFLRIYHACYAYCVGSVNGAETQTDNYHTAMSGKAVTTKYGTFTFDNSGSVLTNYAVFTINPAEMTFESILTLKSVAKSCDTYNCFQLSPNKTSDLLWTLKDMDPPDDCVAKSSCVNYIPHIIAAVVIVTIIVIAIVIIVKQRRHKLNIYKLTWKVPKESLKIIVNKNADAKMQRELENRASNTDNAAALTSRRRVFGSYALVGTQRAEYVQFKQIRKINFPETTLDYLYSLKQLQHDNLAKFYGIQVNDDIMTMTILHTLVERGTLEEFCLDRDFGMDDTFKSAFMRDILKGLQYLHKSSIGYHGHLQASTCLIDINWVLKLTLYGVSNFMSDQLDAENIKVPEQAAHMITYPQYVCFPPEHIREYDDSGKQPPRVVRGSPKGDIYCVGMIFYMMVEREDPYHLIHSVERPNATLIKQILNENHMPRITDDYRQENMLLEMCKECWDRNPDKRPTIKKLIESISTVYPLSKGNLVDQMIRMSEKYADELEQMVAIRTADLADAQMQTMRLLNEMLPASIAKDLKNGLIMPPRSYESATVMFVQICDFNALMKRSSPEQVIAFLNDIYDQFDTVIKRHDAYKVETTGETYMVASGVPHENEGRHIFEVAEISLEIREISYIYVLQHDKNYKLRIRIGFHAGPIAAGVIGIRSPRYCLFGDTVNFASRMQSNCPPNQIQTSEITARLLFDSHEYKFVKRGIVHVKGKGEVNCYWLNEHLHEETEPPLPPMTPVPNPLRRGSIVPLQKA
What is the function of this protein?
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).  Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons (PubMed:8348618, PubMed:10774726).  May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).  Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1 (PubMed:20436480).  Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults (PubMed:10571181).  In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources (PubMed:25009271).  Involved in AWB sensory neuron development and extension during postembryonic development, potentially via mediating localization of tub-1 and PI(4,5)P2 to membrane cilia (PubMed:31259686).
What are the official names of this protein?
Receptor-type guanylate cyclase gcy-10, Odorant response abnormal protein 1.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, cilium. Note=Localizes in cilium of sensory neurons.
Protein: APJB_DANRE
Sequence: MNAMDNMTADYSPDYFDDAVNSSMCEYDEWEPSYSLIPVLYMLIFILGLTGNGVVIFTVWRAQSKRRAADVYIGNLALADLTFVVTLPLWAVYTALGYHWPFGVALCKISSYVVLLNMYASVFCLTCLSLDRYMAIVHSLTSTQLRTRGHMRASLTAIWLLSGVLAAPTLLFRTTVYDVETNRTSCAMDFNLVVSQPGQETYWIAGLSISSTALGFLIPLLAMMVCYGFIGCTVTRHFNSLRKEDQRKRRLLKIITTLVVVFAACWMPFHVVKTMDALSYLNLAPDSCTFLNLLLLAHPYATCLAYVNSCLNPLLYAFFDLRFRSQCLCLLNLKKALHASPASSLSSQKTEAQSLATKV
What is the function of this protein?
Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17336905, PubMed:17336906, PubMed:24316148, PubMed:24407481).  Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:17336905, PubMed:17336906, PubMed:24316148, PubMed:24407481, PubMed:26017639).  Positively regulates angioblast migration toward the embryonic midline, i. e.  the position of the future vessel formation, during vasculogenesis (PubMed:26017639).  May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity).  Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (By similarity).  Plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity).  Acts redundantly with agtrl1a in heart development (PubMed:17336906).
What are the official names of this protein?
Apelin receptor B, Angiotensin II receptor-like 1b, Angiotensin receptor-like 1b, G-protein coupled receptor APJ B, Protein grinch.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to apelin (apln). After exposure to apelin receptor early endogenous ligand (apela), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane.
Protein: RL27_PHYAS
Sequence: MLLKLQIQLFASKKGAGSTRNGRDSHSKRLGAKLSDGQIAKAGSIIYRQRGTKIYPGFNVGLGGDDTLFAKISGIIKYESKRGNRKKVSVYPQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: C71BH_ARATH
Sequence: MAISLLCLFLITFVSLTIVGCKIKRSIWNLPPSPPKLPVIGNLHQVGELPHRSFRRLAERTGHVMLLHLGFVPVTVISSREAAEEVLRTHDLDCCSRPNLVGSRLISRGFKDLNFTPYGEEWKERRRFLVGELFCSKKLQSFIYIKEVECNFLVKKLSESAVDQSPVDLSKTLFWLAASILFRVAFGQSFHESEFTDTDKIDELVFETETAQGSFTCSDFFPIAGLGWLVDWISGQHKRLNDVFLKLDALLQHVIDDHSNPGRSKDHKDIVDVMLDVMHKQGKDDSLRLTIDHIKGLLTNIIIAGIDTGALTMIWTMTELARNPEIMKKVQGEIRDRLGNNRERITKEDLDKVPFLNLVIKETFRLHPVAPLLLPRETMAHVKVQGYDIPPKRRILVNAWAIGRDPKLWTDPEEFKPERFIDSPVDYRGQHFELLPFGSGRRICPGMAMGMATLELGLLNLLYFFDWKLPDGMSHKDIDTEEAGTLTVVKKVHLKLVPVRVP
What are the official names of this protein?
Cytochrome P450 71B17.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ATPG_HERAR
Sequence: MASGKEIRGKIKSVENTKKITKAMEMVAASKMRKAQERMHAARPYSDKIRNIAANLSQANPEYTHPFLVKSDVSKTVGFIIVTTDKGLCGGMNTNSLRIVTTKLRELEAQGKKVETVAIGNKGLGFLNRIGARVVSHAVQIGDTPHLDKLIGPVKVMLDAYQDGKLDAVYVVYTKFINTMKQEPMMEQLLPLAADALKADADSLAWDYIYEPDAQTVIDELLIRYVEALIFQSVAENLASEQSARMVAMKSASDNAGSVIGELKLVYNKTRQAAITKELSEIVAGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MURA_CAMLR
Sequence: MTYLEIDGVEKLSGEVIISGAKNAALPLIASSILAKNEAQISNLPNVADICTLLSLLKNLGASYTFENNFAKINTKDLNKTIAKYDIVRKMRASILTLGPLLARFGNCEVSLPGGCAIGQRPIDLHLLALEKMGANIEIKQGYVVASGKLKGADLMFDKITVTGSENIIMAAALAHGKTRLLNVAKEPEVVQLCEVLAEAGLDIKGVGSDELEIYGTSGELLEFKPFKIIPDRIEAGTYLCAGAITNSKITLKNVNANHLGAVLAKLEQMGFSFDISEDSISINPAKEIKPVEILTSEYPGFPTDMQAQFMALALRANGVSIIDERLFENRFMHVSELLRMGADIRLNGHIATINGTKELFGADVMATDLRASSALILAALAAKGTSKIHRIYHLDRGYENLEEKFKNLGASIRRLEE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEP1_ARATH
Sequence: MSWWWAGAIGAAKKKLDEDEPSQSFESVALIIGVTGIVGNSLAEILPLSDTPGGPWKVYGVARRPRPTWNADHPIDYIQCDVSDAEDTRSKLSPLTDVTHVFYVTWTNRESESENCEANGSMLRNVLQAIIPYAPNLRHVCLQTGTKHYLGPFTNVDGPRHDPPFTEDMPRLQIQNFYYTQEDILFEEIKKIETVTWSIHRPNMIFGFSPYSLMNIVGTLCVYAAICKHEGSPLLFPGSKKAWEGFMTASDADLIAEQQIWAAVDPYAKNEAFNCNNADIFKWKHLWKILAEQFGIEEYGFEEGKNLGLVEMMKGKERVWEEMVKENQLQEKKLEEVGVWWFADVILGVEGMIDSMNKSKEYGFLGFRNSNNSFISWIDKYKAFKIVP
What is the function of this protein?
Involved in vascular strand development.  Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione.  Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone.  May be involved in the formation of 5-beta phytoecdysteroids.
What are the official names of this protein?
3-oxo-Delta(4,5)-steroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, Delta-4,5-steroid 5-beta-reductase, At5beta-StR, Progesterone 5-beta-reductase, 5beta-POR, Protein VEIN PATTERNING 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. Highly divergent.
Protein: RL10_SHEFN
Sequence: MALRLEDKQAIVAEVNEAAKGALSAVVADSRGVTVGAMTGLRKAARENGVFVRVVRNTLARRAVQGTAFECLAETFTGPTLIAFSNEHPGAAARLLKDFAKGQAKFEVKGAAFEGMFIPAADIDRLAKLPTYEEALAQLMMTMKEASAGKFVRTLAALRDQKQDAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: LTOR4_MOUSE
Sequence: MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFQLHHGTNIPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR4, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR4 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: TAL1_DANRE
Sequence: MMEKLKSEQFPLSPSAEGCASPPRGDGDARGKQEGTTAETGEHRLPEELNGVAKETAHHATELKKEVAVIELSRRGGSADIKGRELKAELSHKVQTTELCRPPIPLPLPPRDPLSDTRMVQLSPPAFPLPARAMLYSNMTTPLATINSGFAGDAEQYGMYPSNRVKRRPAPYEVEINDGSQPKIVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQDDMVGGEAPARANRDSRDATLVRDDLLQEMLSPNSSCGSLLDGDASPESFTEDQDSSVESRPSARGLHHSSLPLDGNAQR
What is the function of this protein?
Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo.  Specifies mesodermal precursors to a hemangioblast cell fate.  Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells.  Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels.  Specification of definitive hemopoietic stem cells requires isoform beta.  DNA binding is required for erythroid maturation, but not for its other hemopoietic functions.  Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo.  Required for angiogenesis but not angioblast specification.  Has an additional role in endocardium formation during heart development.  May play a role in central nervous system development.
What are the official names of this protein?
T-cell acute lymphocytic leukemia protein 1 homolog, TAL-1, Stem cell protein, zSCL.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSRAB_STRP1
Sequence: MIYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADLAIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADEYRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVVRYKEDKSFNMTRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA/MsrB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
Protein: GLK_BACSU
Sequence: MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITVTIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETETGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGGEIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSARDVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVEKTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC
What is the function of this protein?
An ATP-dependent kinase that phosphorylates glucose to make glucose-6-phosphate, not active on fructose, galactose or mannose.  Restores glucose kinase activity in E. coli glk mutants.
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRT_BOVIN
Sequence: MAARSPSVVISDDEPGYDLNLFCIPNHYAEDLEKVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDKSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLALVKKHKPKMVKVASLLMKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
What is the function of this protein?
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate.  Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine.  Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
What are the official names of this protein?
Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU32_DECAR
Sequence: MKICVIPGDGIGVEICAEAVRVIDALKDIHGLKIEYEYGLLGGAAYDQTGRPLPVETLRLADEANAILLGAVGGPKWDKLPAESRPERGLLGIRKYLGLNANLRPIKVYPELANASTLRPEVVSGLDMMIVRELTGDIYFGQPRGIRTSGFERVGYNTMEYSESEIALIAEMAFRIARQRSGKVMSVDKMNVLECMQLWRDVVTKVGERFPDVTLDHMLVDNAAMQLVKNPKQFDVLLTGNMFGDILSDEAAMLTGSIGMLPSASLNVEDKGMYEPCHGSAPDIAGQGVANPLGMILSAAMMFRYSLGRPDMADAIESAVQTVLTNGARTRDIFQAGDRLVSTSEMGGLVEAALRRIS
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase 2, 3-IPM-DH 2, Beta-IPM dehydrogenase 2, IMDH 2.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1333_MYCTU
Sequence: MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGAVDCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSGVVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKGGVGTASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALAQLSSPLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALATGAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYRDMFPGAFGS
What is the function of this protein?
Aminopeptidase.
What are the official names of this protein?
Uncharacterized aminopeptidase Rv1333.
What is the protein family that this protein belongs to?
Belongs to the peptidase S58 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BLA1_STRCI
Sequence: MRIRPTRRLLLGAVAPLALVPLVACGQASGSESGQQPGLGGCGTSAHGSADAHEKEFRALEKKFDAHPGVYAIDTRDGQEITHRADERFAYGSTFKALQAGAILAQVLRDGREVRRGAEADGMDKVVHYGQDAILPNSPVTEKHVADGMSLRELCDAVVAYSDNTAANLLFDQLGGRRGSTRVLKQLGDHTTSMDRYEQELGSAVPGDPRDTSTPRAFAEDLRAFAVEDGEKAALAPNDREQLNDWMSGSRTGDALIRAGVPKDWKVEDKSGQVKYGTRNDIAVVRPPGRAPIVVSVMSHGDTQDAEPHDELVAEAGLVVADGLK
What are the official names of this protein?
Beta-lactamase 1, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.