PharMolix/UniProtQA huggingface dataset:
Protein: DXS_STRC1
Sequence: MTILENIRQPRDLKALPEEQLHELSEEIRQFLVHAVTRTGGHLGPNLGVVELTIALHRVFESPVDRILWDTGHQSYVHKLLTGRQDFSKLRGKGGLSGYPSREESEHDVIENSHASTALGWADGLAKARRVQGEKGHVVAVIGGRALTGGMAWEALNNIAAAKDQPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYEKVLAWGKDVLLRTPIVGHPLYEALHGAKKGFKDAFAPQGMFEDLGLKYVGPIDGHDIGAVESALRRAKRFHGPVLVHCLTVKGRGYEPALAHEEDHFHTVGVMDPLTCEPLSPTDGPSWTSVFGDEIVRIGAEREDIVAITAAMLHPVGLARFADRFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADHVRAQLREAVAVDDAPTLIRFPKESVGPRIPALDRVGGLDVLHRDERPEVLLVAVGVMAQVCLQTAELLRARGIGCTVVDPRWVKPVDPVLPPLAAEHRLVAVVEDNSRAAGVGSAVALALGDADVDVPVRRFGIPEQFLAHARRGEVLADIGLTPVEIAGRIGASLPVREEPAEEQPA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: F16PC_STAXY
Sequence: MHNSTDKSVKERFLDLLSEQFNTKEALATEIINLESILELPKGTEHFVSDLHGEFHSFQHVLRNGSGNVRSKINDIFQDTLTRKEINEFSALVYYPEEKLQLIKNSFSSKSELNEWYITTINRLIKLITYASSKYTRTKLRKSLPENYVFIVEELLYKSNKYNNKHSYYETLIKQIIELEQSDDLIIGLSFTVQHLVVNHLHVVGDIYDRGPEPDKIMETLIDYPSVDIQWGNHDVLWIGAYAGSKVCLANLLRICARYDNLDIIEDAYGINLRPLLTLADKYYDGSNPAFRPKNAEGLSELELEQITKLHQAIAIIQFKLEAPIIKRRPAFEMEERLVLEKIDYDKNEATLYGKTYPLEHTCFQTVDPNDPNKLTDEEADVIDKLLLSVQQSEKLKRHMTFLMQKGKLYLPYNGNLLIHGCIPVDEQGEMESMVIDGVKCYGRDLLDHFEEYVRIAFDHKDIQDDLATDLVWYLWTGKYSSLFGKRAMTTFERYFIKDKTAHKETKNPYYYLREDVDMCKKMLKDFGLDPEQGHIINGHTPVKEIDGEDPIKADGKMIVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQHFNSKKHVLLNGADELSIRRVVDKELQRKKIRDTNTGHEIQAQIDILKELMHDRFVN
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: RL15_STAAT
Sequence: MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SDHD_BURL3
Sequence: MRYRSMTVTLQPADLLARLQSRHPLLWLNPHAGSPLPHDAPGPGAIATAEARLARCEPLMAELFPELATSAGKIESPLMPADNLQRTLSLPADTHGAWFIKRDDALPIAGSIKARGGFHEVLALAESIAIEHGLLEPAGDRRILASAAARERFAAHTVIVGSTGNLGLSIGVMASALGFESVVHMSTDAKPWKKARLRQRGVRVIEHDGDYAQAVAAGRAQARNQPRSHFVDDEGSLMLFLGYAASARHLAAQLAEAGRRVDATHPLFVHIPCGVGGAPGGIAHGLKALFGEHVHCFFAEPVASPCMLVQLAAGLGKPVSVYDVGLDNRTEADGLAVAQASHLVSPLMASLLSGVFTVSDAQLYAQLLAVQHATGVELEPSAAAAVGGPGWLTRSPAGRDYVHRHAIDLRQSTHVIWATGGSLVPPEEHRRFQSHAKALAGAAAGT
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: DEFB1_GORGO
Sequence: MRTSYLLLFTLCLLLSEIASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYGGKAKCCK
What is the function of this protein?
Has bactericidal activity.  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Protein: ACP_THEPX
Sequence: MIFEKVRDIIAEQLGIDPEEITMESSFIDDLGADSLDIVELIMALEEEFDIEIPDEDAEKIKTVGDVVEYLSNLE
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_PROMM
Sequence: MVITGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYVQTIEAAAAKIYGQSVRVSVQAQEEDSAERVLPPMTSASIPSPLPTAETTTASVAPSSGPRRILPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPLFICGGVGLGKTHLMQAIGHYRLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQEEFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQKKAEQERMMLPRDLIQYIAGRFTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQGVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVGMYLMRQGTDLSLPRIGETFGGKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAD1_BETPN
Sequence: MARSTSKDAQALIQSLRSAYAATPSNLKIIDLYVVFAVFTALIQVVYMAIVGSFPFNAFLSGLLSCIGTAVLAVCLRIQVNKENKEFKDLAPERAFADFVLCNLVLHLVIMNFLG
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Oligosaccharyl transferase subunit DAD1, Defender against cell death 1, DAD-1.
What is the protein family that this protein belongs to?
Belongs to the DAD/OST2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VPU_HV1C4
Sequence: MQSLEIVAIVELVVAAIIAIVVWTIVFIEYRKILRQRKIDRLIDRIREREEDNGNESEGDQEELSALVEMGHHAPWNVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: RL31_PYRNV
Sequence: MSEERKVVASREYVISLRRAYVVSRTKRAKYAVGLIRRFVARHLKVEPSAVKIGQKLNMELWSRGIEKPPRRVRVSVEKYSDGTALVELKE
What are the official names of this protein?
50S ribosomal protein L31e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: PP217_ARATH
Sequence: MVGFARTKFCKNLSSLSDNGENHEKPYTFEGNRQTVNDICNVLETGPWGPSAENTLSALSFKPQPEFVIGVLRRLKDVNRAIEYFRWYERRTELPHCPESYNSLLLVMARCRNFDALDQILGEMSVAGFGPSVNTCIEMVLGCVKANKLREGYDVVQMMRKFKFRPAFSAYTTLIGAFSAVNHSDMMLTLFQQMQELGYEPTVHLFTTLIRGFAKEGRVDSALSLLDEMKSSSLDADIVLYNVCIDSFGKVGKVDMAWKFFHEIEANGLKPDEVTYTSMIGVLCKANRLDEAVEMFEHLEKNRRVPCTYAYNTMIMGYGSAGKFDEAYSLLERQRAKGSIPSVIAYNCILTCLRKMGKVDEALKVFEEMKKDAAPNLSTYNILIDMLCRAGKLDTAFELRDSMQKAGLFPNVRTVNIMVDRLCKSQKLDEACAMFEEMDYKVCTPDEITFCSLIDGLGKVGRVDDAYKVYEKMLDSDCRTNSIVYTSLIKNFFNHGRKEDGHKIYKDMINQNCSPDLQLLNTYMDCMFKAGEPEKGRAMFEEIKARRFVPDARSYSILIHGLIKAGFANETYELFYSMKEQGCVLDTRAYNIVIDGFCKCGKVNKAYQLLEEMKTKGFEPTVVTYGSVIDGLAKIDRLDEAYMLFEEAKSKRIELNVVIYSSLIDGFGKVGRIDEAYLILEELMQKGLTPNLYTWNSLLDALVKAEEINEALVCFQSMKELKCTPNQVTYGILINGLCKVRKFNKAFVFWQEMQKQGMKPSTISYTTMISGLAKAGNIAEAGALFDRFKANGGVPDSACYNAMIEGLSNGNRAMDAFSLFEETRRRGLPIHNKTCVVLLDTLHKNDCLEQAAIVGAVLRETGKARHAARSW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g06920.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: LPXB_RICBR
Sequence: MKKIYFIAGEASGDFAGGRIIRNLKADKELKIIGIGGRNMEEAGNFESLFPISEINLMGFFEVIPHIFRIKKLINKTVEDIIDNKPDILITIDSPGFTYRVAAKVRERLPELKMIHIVAPSVWAYKEGRAAKYAKIYNCLFALLPFEPPYFTKVGLDCRYIGHPIMEQEFYSDKVALRQELEIDEDTKVLCVTLGSRKGEILRHLPIFIPAIEKVYDDHKKKLMVIFPLANPDHERIIKPFLEKVRFNYIFSYERLKSYAVSDLALAKSGTNTLEIAASGTPMIVAYKVNIFSFIIIRLLIKIKYVTLINIIGNREIIPEFIQFNCEANLISDKLKELLLNPQEVDKQITESHKILQELGFKSNIYPSYLATKIIRQEFLK
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: FUMC_CHLCV
Sequence: MRQENDSLGIVEVPEDKLYGAQTARSQKYFSWAPEVMPKEVIRALVLIKQCAAKANHDLGFLDSKYCDMIVSAASEILEGGFEEHFPLKVWQTGSGTQSNMNVNEVIANLAIQRHGGVVGSKTPIHPNDHVNKSQSSNDVFPTAMHIAAVINLKKKLIPAMDHLQRALDAKVAEFRDCVKIGRTHLMDAVPMTLGQEFSGYSNQIRQSLERVAFSLTHMYELAIGGTAVGTGLNVPNGFIDKVIHYLRQETGEPFVAASNYFSALSNHDTLVNAHGVLATLACALTKIATDLSFLGSGPRCGLGELLFPENEPGSSIMPGKINPTQCEALQMVCAQVIGNNQAVIMGGSRGNFELNVMKPVIIYNFLQSVDILAGGMQAFADYFVSGLRVNKPRLKEYLDNSLMLVTALTPVLGYDKCSKMALKAFHDNINLKEACIQMGYLSAEEFDRLVVPESMVGKF
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC2_PSEPK
Sequence: MHTPVVFIDGDQGTTGLQIHARLQGRSDLRLLTLPEAERKDPQRRCEAINSADIALLCLPDDAAREAVAAIHNPQVRVIDASSAHRTTPGWVYGLPELDEQQAERIAQSTRVSNPGCYPTGAIALLHPLVKAGLLPADYPLNIHAVSGYSGGGRAAVERHEQPGAAKAPALQLYGLELAHKHVPEIQQHAGLSARPMFMPGYGAYRQGIALSIPLQLRLLPGQVSAEHLQACLEQHYQGARHVQVMPLHQCGAAANLDPEALNGSNDLRLALYANPEHGQVLLTAVFDNLGKGASGAAVQNLDLMLGALQAHG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase 2, AGPR 2, N-acetyl-glutamate semialdehyde dehydrogenase 2, NAGSA dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EME1_MOUSE
Sequence: MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD
What is the function of this protein?
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick.  Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions.  May be required in mitosis for the processing of stalled or collapsed replication forks.
What are the official names of this protein?
Crossover junction endonuclease EME1.
What is the protein family that this protein belongs to?
Belongs to the EME1/MMS4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
Protein: MRAY_PSEP1
Sequence: MLLLLAEYLQQFHKGFAVFQYLSLRGILGVLTALSLALWLGPWMIRTLQIRQIGQAVRNDGPQSHLSKSGTPTMGGALILSAIAVSTLLWADLSNRYVWVVLIVTLAFGAIGWVDDYRKVIEKNSRGLPSRWKYFWQSVFGLAAAVFLYKTAPTSVETTLILPFIKDVTIPLGVGFVVLTYFVIVGSSNAVNLTDGLDGLAIMPTVMVGGALGIFCYLSGNVKFAEYLLIPYVPGSGELIVFCGALIGAGLGFLWFNTYPAQVFMGDVGALALGAALGTIAVIVRQEIVLFIMGGIFVVETLSVVIQVASFKLTGKRVFRMAPIHHHFELKGWPEPRVIVRFWIITVILVLIGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA_RICCK
Sequence: MKLKPIEVAEILQKEIANINCLSELEEVGQVITVGDGIAKIYGLANVKSGEVVEFKSGVKGLVLNLENDSVSAVIMGDDNQVQQGDNVKRIKEVLAVPVGKALLGRVVDVFGNPIDGKGDIASKEYRNIEVKAPGIIERASVSEPVQTGIKAIDSLIPIGRGQRELIIGDRQTGKTAIAVDTIINQKQAHLLTNEHDKIYCIYVAIGQKRSSVAQIVRKLEAAGAMGYTIVIAATASEAAALQFIAPYSACSMGEYFRDNGMHALIIYDDLSKHAVAYRQISLLLRRPPGREAYPGDIFFLHSRLLERAAKMSDAKGSGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFYKGIRPAVNVGISVSRVGSAAQIKAMKQVAGSVKLELAQFRELESFSQFESDLDPTTKAQIDHGKRLVEILKQAQYHPFPVEEQIVSIYVGTKKYLHDVPLQKVKEFEDKMLTEIRLNKNDILESIKNEKRITEETEQKLKTFLENFVKAFIKAS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FICD_CAEEL
Sequence: MSVRRRTHSDDFSYLLEKTRRPSKLNVVQEDPKSAPPQGYSLTTVIIISVLVSLICQHFVPYAVSTLHTVIKNSPKQKSSPPPSNRLNIGFISGNSPEKYAPAVQKPTFLVDPIYDEKWKGIQTAVPVMSTQTDEKRENDPAKVKEAILAAKAAGRSRKDGNLERAMTIMEHAMALAPTNPQILIEMGQIREMHNELVEADQCYVKALAYDPGNSEALVLRARTTPLVSAIDRKMLRSVHDLRDEFNHLQHSTALRRMMRETYFLYVYHTVAIEGNTLSLGQTRAILESGMVIPGKSIREHNEVIGMDAALRFLNCSLLSKEHDEISIDDILEMHRRVLGNADPVEAGRIRTTQVYVGRFTPVSPEYVMEQLKDIVDWLNDESTLTIDPIERAAIAHYKLVLVHPFTDGNGRTARLLLNLIMMRSGFPPVILPVETRAEYYASLHVANLGDLRPFVRYVAKHSEASIQRYIGAMKTSSDNILNSGDSKLTPEESEVSEKIEAECRAGN
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity).  The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity).  Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (PubMed:27138431).  In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2 (PubMed:27138431).  Can AMPylate core histone H3 in vitro (PubMed:27138431).  Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins (By similarity).  Decreases susceptibility to P. aeruginosa-mediated killing and might therefore play a role in the innate immune response (PubMed:27138431).
What are the official names of this protein?
Protein adenylyltransferase fic-1, De-AMPylase fic-1.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Predominantly localized to the endoplasmic reticulum and to the nucleus.
Protein: NDHJ_PROM5
Sequence: MDQNNLSKSSEEIVEQRGIVSNRLYKDGITNNSLGNDHIGVELLSVKPEKLYEAISSLKKYGFNYLQCQGGYDEGPGKRLVSFYHLISLQDIEELEEIKEIRVKVFLNRDSDLSVPSLYKIFKGSDWQERETYDMYGINFQDHPNPKRILMPEDWRGWPLRKDYIQPDFYELQDAY
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J, NDH-1 subunit J, NDH-J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS18_RICBR
Sequence: MSKNNTSETITRKPMERASKKVFFRRRKGCPLSVPNAPVIDYKNPELLIKFVSEGGRMLPSRITNVCAKKQRKLNNAIKIARILALLPFVFQAK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL17_BOMMO
Sequence: MGRYSREPDNPAKSCKARGSNLRVHFKNTYETAMAIRKMPLRRAVRYLKNVIEKKECIPFRRFNGGVGRCAQAKQFGTTQGRWPKKSAEFLLQLLRNAESNADNKTLDVDRLVIDHIQVNRAPCLRRRTYRAHGRINPYMSSPCHIEVCLSEREDAVARVAPTDDAPAKKKLSKKKLARQKEKMMRE
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OTSA_SALPB
Sequence: MSRLVVVSNRIAPPDNKGGAGGLAVGVLGALKAAGGLWFGWSGETGNEDEPLKKVTKGNITWASFNLSEQDYEDYYCQFSNAVLWPAFHYRLDLVQFQRPAWEGYMRVNALLADKLLPLIKENDIIWVHDYHLLPFASELRKRGVNNRIGFFLHIPFPTPEIFNALPPHDELLEQLCDFDLLGFQTENDRLAFLDSLSSQTRVTTRSGKQHIAWGKDFQTEVYPIGIEPDEIALQAAGPLPPKLAQLKAELKNVKNIFSVERLDYSKGLPERFLAYEALLENYPQHRGKIRYTQIAPTSRGEVQAYQDIRHQLETEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEFVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDDVAAALNRALTMPLAERISRHAEMLDVIVKNDINRWQERFIHDLKEVTPRSPERQQQNNVATFPKLA
What is the function of this protein?
Probably involved in the osmoprotection via the biosynthesis of trehalose.  Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate.  Acts with retention of the anomeric configuration of the UDP-sugar donor.
What are the official names of this protein?
Trehalose-6-phosphate synthase, TPS, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], Osmoregulatory trehalose synthesis protein A, OtsA, UDP-glucose-glucosephosphate glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: RL32_AGRRK
Sequence: MAVPKRKTSPSKRGMRRSADALKASTYVEDKNSGELRRPHHIDLKTGMYRGRQVLTPKESA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RS8_TROW8
Sequence: MTMTDPLSDMFSRIRNANQVLHKKVTVPSSRLKVSIADLLKREGYILDYSVIDEHPGQLLVIELKYGPDKSRALVGLKRVSKPGLRVYAKSSNLPEVFGGLGIAILSTSSGLLTCSQARKKGVGGEVLAYAW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NFI_ECO24
Sequence: MDLASLRAQQIELASSVIREDRLDKDPPDLIAGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEMLSQKPDLVFVDGHGISHPRRLGVASHFGLMVDVPTIGVAKKRLCGKFEPLSSEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSVDSALAWVQRCMKGYRLPEPTRWADAVASERPAFVRYTANQP
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_ECO5E
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.