PharMolix/UniProtQA huggingface dataset:
Protein: ATX3_ORYSJ
Sequence: MEEAAAASNGGLLYHEVQEGKLCAVHCVNTTLQGPFFSEFDLSALAVDLDQRERQVMSEGAAGAATTAAGDFLAEGEGSHNVSLGGDFSIQVLQKALEVWDLQVIPLDSPDVGSCLFDPELETAFICHLQDHWFCIRKVNGEWYNFNSLYPAPEHLSKFYLSAFIDTLKGSGWSIFAVRGNFPKECPMATEGSNGFGQWLTPDDARRITSSCNQVQTPTQQAGVSLVADQSEEMSEMDMIAAQQEEADLNAAIAASLMDTGGPFANYAAHEESRSQDAFAIESTSGEMSKDGNLEEQGANKSETSEPNSDNIESASGSNPKQNTTSLEGKESIKED
What is the function of this protein?
Interacts with key regulators of transcription and represses transcription.  Acts as a histone-binding protein that regulates transcription.  Acts as a deubiquitinating enzyme (By similarity).
What are the official names of this protein?
Putative ataxin-3 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEXA_ECOL5
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: AROB_RALSO
Sequence: MITVDVDLGERAYPIHIGTGLLSQAELFAPHIRGTRAVIVTNETVAPLYAARVEAAIRSLGKTVDMVVLPDGESFKTWETLNRIFDALLASGADRKTTLVALGGGVIGDMTGFAAASYMRGVPFIQVPTTLLSQVDSSVGGKTGINHPLGKNMIGAFHQPQAVLADIDTLRTLPPRELAAGMAEVIKHGAIADADYFAWIERHIAGLNACDADLMAGAVRGSVQIKAAVVAQDERESGLRAILNFGHTFGHAIEAGLGYGEWLHGEAVGCGMAMAADLSHRLGFIDIDTRNRVTALTRAANLPVVAPDLGVARFIDLMRVDKKAEAGEIKFVLLRKLGQAFVTTVPDTDLRATLQHAVLRPPTEAPVA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIP1_CAEEL
Sequence: MSSLCPYTGRPTGLFRDFEDMMPYWAQRHSMLNNFNNIVPQQLNEVENTAQKFCVKLDVAAFKPEELKVNLEGHVLTIEGHHEVKTEHGFSKRSFTRQFTLPKDVDLAHIHTVINKEGQMTIDAPKTGSNTTVRALPIHTSAGHAVTQKPSSTTTTGKH
What are the official names of this protein?
Stress-induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: PYRE_SULAC
Sequence: MDFVKALLDKKLLLIGNFMLTSGKVSPYYLDLRKLPNHPDIFSFVVSSAVDIVKGINFDMILGVVTGGVPFASFIACKLNKPMGYIRAEKKGHGTERLLEADVDGKKVIVVDDVATTGGSILKAVEEVRKAGGKVEHALVIVDREEGAFEKLESVGIRLLSVYKVSEILNSLIKSNLVAENEKKLISDYMVKNIGKS
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TRPA_LEPCP
Sequence: MSRIAATFARLAGQGRKALIPYVTAGDPFADITVDLMHAMAKAGADVIELGVPFSDPMADGPVIQRASERALSRNISTADVLAMVARFRETDDTTPVVLMGYANPVERYGPDRFVDDARAAGVDGVLVVDYPPQECEAFADRLRAADLDPIFLLAPTSTDARMADVGRIATGYVYYVSLKGVTGSGNLDTDAVARMIPRIRSHVSVPVGVGFGIRDAATAVAVARVSDAVVIGSRIIQLIENEPRERVVPVAAGFIAEIRTALDTLQGTHA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PCL_CERS4
Sequence: MTAEGPLAPEDRVLDREAIGRLCVSLIAAEQQDLLREGRVGHHQMIGARLLTAGHPSPDDLLIDEDTLGLDSLLMLSLVTRVAGFFHLSDSNTEDYLLVRRRLGEWVDLIDHHHTLMGPKARFTFATSGSTAGPKPVTHSAAALLSEGQAIAKILTERPPEVRRVLSCVPAHHIYGFLWSCLFPSRRGLEAKQLANLSASGIMRHARSGDLVVGTPFIWEQFADLDYRLPGDVVGVTSGAPSTAETWRCASALGPARMLDIYGSTETGGIGWRERRDDPFRTLPDLACFHDTLSRLGRRLDLQDEIAWDKDGGFTILGRKDEILQVAGSNVSPAAVRDILLRNPRVRDAAVRLDGRRLKAVISVAEGADEAEIEIELRATAARHLPAPARPDRFLFATELPRTGAGKLADW
What is the function of this protein?
Converts p-coumaric acid into p-coumaryl CoA.  This is necessary for the activation of the photoactive yellow protein (PYP) chromophore.
What are the official names of this protein?
4-coumarate--CoA ligase, 4CL, 4-coumaroyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PIT_RHIME
Sequence: MDATLAFPLLVGLIAVALFFDFLNGLHDAANSIATIVSTRVLRPQYAVFWAAFFNFIAFLFFGLHVAETLGTGIIDPGIVTPQVIFAALMGAITWNIVTWVFGIPSSSSHALIGGLVGAGLAKTGFSSIVWQGLLKTAGAIVMSPGIGFVLALLLVLIVSWLFVRQTPFAVDSTFRVLQFVSASLYSLGHGGNDAQKTMGIIAVLLFSQGYLGSEFYVPFWVVITCQAAIALGTLFGGWRIVHTMGSKITKLNPMQGFCAETGGAITLFAATWLGIPVSTTHTITGAIIGVGAARRVSAVRWGLAGNIVVAWVITMPAAALISALCYFAADLVA
What is the function of this protein?
Low-affinity inorganic phosphate transporter.
What are the official names of this protein?
Probable low-affinity inorganic phosphate transporter.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMR1B_XENLA
Sequence: MEELAVEVRGSNGAFYKAFVKDVHEDSITVTFENNWQQEKQIPFHDVRFPPPSGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIDRLRSVNPNKSATKNSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDSENYQLVILSVNEVTIKRANMLCDMHFRSLRTKLSLMLRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENDKNISQEEGNVPFVFVGTKDSITNATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPSNRPDKEKGYLSEDCSGTVRGSRPYNNRGRSRRGTGYASGTNSEASNASETESDHRDELSDWSLAPAEDDRDNYHRRGDGRRRGGMRGQGMRGRGGFKGNDDQPRPDNRQRNSRETKARTSDGSLQIRIDCNNERSVHTKTLQNASVEGSRLRTGKDRIQKKEKTDGVDGPQVVVNGVP
What is the function of this protein?
Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs.  Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity).  Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C) (By similarity).
What are the official names of this protein?
Fragile X messenger ribonucleoprotein 1 homolog B, xFMR1-B.
What is the protein family that this protein belongs to?
Belongs to the FMR1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome, centromere. Chromosome. Cytoplasm, perinuclear region. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Synapse, synaptosome. Cell projection, growth cone. Cell projection, filopodium tip. Synapse. Postsynaptic cell membrane. Presynaptic cell membrane. Cell membrane.
Protein: SIR4_TRYB2
Sequence: MADRLAIFIKQCGLQRCVILTGAGCSTESGVPDYRGPNGLYRRPNFVPLTRQVFLSGSEHRKRYWARSMFGYNTVSGASCNDTHMGLYELYRAGVVNRLLTQNVDGLHHLAAHGGTGSKTVEAYAKYTSSNSGVLELHGNIHQVCCMQCGDVSPRRRLQQRLCEANYQLCRDYEAEFSEVRPDGDYEVPDRVVQAMQLVCCEHCGGLLKPHVVLFGENVPKECVREAYTAVRAASCLICLGTSLQVFSALRFVLAARESGVPIAIVTAGRTRADGLEELKVDTNSTAATMRGVVKQLLGFELGGTK
What is the function of this protein?
NAD-dependent protein deacylase.  Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
What are the official names of this protein?
NAD-dependent protein deacylase SIR2rp2, Regulatory protein SIR2 homolog 2, SIR2-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RUVB_STUS1
Sequence: MIEADRIVTASSRDRDEQLDRAIRPLKLAEYIGQPVVREQMDLFIRAAKGRQEALDHTLIFGPPGLGKTTLANIIAEEMGVSIKSTSGPVLERPGDLAALLTNLEAGDVLFVDEIHRLSPIVEEVLYPAMEDFQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGMLTNPLRDRFGIVQRLEFYSTEDLATIVRRSAGILGLPTEPEGAFEIARRARGTPRIANRLLRRVRDFAQVRGKGEITRQIADLALNMLDVDERGFDHQDRRLLLTLIEKFDGGPVGIDSLAAAISEERHTIEDVLEPYLIQQGYIMRTPRGRVVTRHAYLHFGLNLPKRMNEPPTPDLFEGDIV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: THII_CLOPE
Sequence: MNNLILVKYASEIFLKGLNKNKFERKLKENIRKKLKDIDHEFITDQNRWFIKSEDLDGVIERVKKVFGVKELCLVTQVTGDFDSIKEEGLKKIKESKAKSFKVETNRANKKFPMNSMEVSRAVGGYILSELGDEIEVDIHNPECKLYVEIRGNAYVFTDKDKIKAVGGLPYGMNGSTMVMLSGGIDSPVAAYLMARRGVETHCVYYHSHPYTSERAKDKVKELAKIVGRYTEKITLYVVPFTEIQMDIIEKCREDELTIIMRRFMMRVACELSEKKKIQSITTGESIGQVASQTMEGLIVSNDASDRPVFRPLIAMDKEDIMDIARDIDTYETSILPYEDCCTIFVPKHPKTKPRVKDMIIAERKLDIEALVNKAIDEMETFIFE
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPL2_PICSI
Sequence: MKPEAGDGRSGWRWVATFDLILRLAAIVATSTAVLAAMGKTFVVVVNGVACFYLLMSLPVSIFNIMRPGACPANRAVLTALDMVTVALVTAGALVAGILYLVHKAGDTHADWFSIWSQLDSLSYLAVLALILHVLLSGSILYKQALNIMF
What are the official names of this protein?
CASP-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS12_NOCFA
Sequence: MPTINQLVRKGRRDKVAKTKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y2387_METMA
Sequence: MIELRNLSYTYGTAEEPSLKNINLKVKKGELLLVTGHSAAGKTTLALAMAGILHHEIGGKIEGNLSFKNRDIKEFDGIKELSRHTGMVFDDAESQLIFTTVEEEILSGLENRGYSGKEIQRRLNEVMELCEIGHLKERAPHTLSGGQKQKVALAATLALDTEVLILDEATAELDTEAVRKVFSVLKRLKEAEKTIIIVDHNIEDFLEIGDRVVLLEKGEIKAIKSPADFAAVSEDTDLTSKSSKKEYSCSQKERQPVISIKNLTQRYGEFNALDNLDLEIRSGELVAILGENGSGKTTLVKHLNGLLRPYSGNVSVKGLNTSLTPVNELVKHTGLVFQNPDNMLFEDTVEAEVAFGLNNIGITGSEAGDAIARSLELVNLKGKEKVFPRHLSRGERQRLAVACVIAMRPELIILDEPTTGLDAEESDRMMQLMKRLQLEGHTILMVTHNMQIVKDHAERVIRMASGKIVEDSANGACNSFKRNIKCVEEKCAEGGAIV
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MM_2387.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RAB30_HUMAN
Sequence: MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPGEGKSISYLTCCNFN
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
What are the official names of this protein?
Ras-related protein Rab-30.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans- Golgi network. Cytoplasm. Golgi apparatus.
Protein: NOG2_ASHGO
Sequence: MGTAKKEQQRRIREGNTKDGNLRVKGENFYRDGKRVKFLNMYKGGKSIRNAKGDLIRAAPLQSTDVPTARVQPDRRWFGNTRVISQDALQHFRDALGDKKNDSYQVLLRRNKLPMSLLEEKDTSESPTAKIIDTEPYGATFGPKAQRKKPRVAAASLEDLAKATDSDSQKYEEKKELDSTLGLMAATEQEDGWSQVAKEAIFHKGQSKRIWNELYKVIDSSDVVIHVLDARDPLGTRCKSVEEYMKKETPHKHLIYVLNKCDLVPTWLAAAWVKHLSKDRPTLAFHASITNSFGKGSLIQLLRQFSQLHKDRQQISVGFIGYPNTGKSSIINTLRKKKVCQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSAKDTEEDILFRGVVRVEHVSHPEQYIPAVLRRCKRHHLERTYEISGWADATEFIEMLARKQGRLLKGGEPDETGVAKQVLNDFNRGKIPWFVSPPDRDPQPETSKRPADSEPETAQEAPEPPANKRLRV
What is the function of this protein?
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
What are the official names of this protein?
Nucleolar GTP-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS1_PSEPW
Sequence: MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQDDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYGGQGLYEPLDLQIARCKLMTAGVVGAPEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLINLADKIIDVVDTGNTLRANGLEPQDLIATISSRLVVNKASMKMQHARIQSLIDTLRQAVESRHRG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_RICPU
Sequence: MRQSGRKSNQLRPISLELSPLINAEGSCLIKIGNTHVMCSATCETTVPPFLRGQNQGWITAEYGMLPGSTSQRIKREAALGKQGGRTQEIQRLIGRAMRCVIDVRKLGERQIIIDCDVINADGGTRTAAITGSYVALHLAIRSLMKKRVLKVNPLISQIAAISCGIYKGEAILDLDYLEDSDADVDSNFVFAGNGNLIEVQGTAEKNPFSEEQFLAMLKLAKGGAAELFKLQNQVLLGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: YN9A_YEAST
Sequence: MSNSNGDNKYGVITIGDEKKFQATIAPLGATLVDLKVNGQSVVQGYSNVQDYLTDGNMMGATVGRYANRIAKGVFSLDDGPHKLTVNNCGNTNHSSISSLNLKQYKASPVENPSKGVYVVEFKLLDDHTQPNPNEFPGDLEVTVKYTLNVAEMTLDMEYQAQLVRGDATPINMTNHSYFNLNKVKSEKSIRGTEVKVCSNKSLEVTEGALLPTGKIIERNIATFDSTKPTVLHEDTPVFDCTFIIDANKDLKTTDSVSVNKLVPVFKAYHPESHIKFEVSTTEPTVHLYTGDNLCGKFVPRSGFAVQQGRYVDAINRDEWRGCVLLKRGEVYTSKTQYKFDI
What are the official names of this protein?
Uncharacterized isomerase YNR071C.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
Protein: RS5_THEVO
Sequence: MSDEWTPRTQLGKLVASGQIKTISEALKTKLPLKEYEIVDYLLPNIKDEVIDIKRAQRMTDSGRRMTYSITVVVGNEDGYIGLGIGRSKEAAPAIRKALINAKLNIMEIRRGCGSWECGCGRAHTLPFLVEGKSGSVRITLKPAPRGVGLAVGNVAKIILRMAGIEDAWGFAAGHTKTTVNYALAVYNALKETAKVRINPGIVLSTPIYSGSVINVSGHTD
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PELO_DANRE
Sequence: MKLVHKDIEKDNAGQVTLIPDEAEDMWHTYNLLQVGDSLRASTIRKVQTESSTGSVGSSRVRTTLTLCVETIDFDSQACQLRVKGTNIQENQYVKMGAYHTIELELNRKFTLAKKVWDSVVLDRIEQACDPAQKADVAAVVMQEGLANLVLVTPAMTLLRAKVEVTIPRKRKGSCTQHDKALERFYEAVMQGILRHFNFDVVKCILVASPGFVKDQFISYLFKEAVRQDCKLLLENRSKFMVVHSSSGHKYSLKEVLCDPAVTARLSDTKAAGEVKALEDFYKMLQQEPDRAFYGLAHVERASEALAIDILLISDTLFRHQDVATRGRYVRLVDNVKENGGTVRIFSSLHVSGEQLNQLSGVAAILRFPIADVSEPEENSSSDED
What is the function of this protein?
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway.  Required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes.  Recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway.  Upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ACTC_HALRO
Sequence: MCDEDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVFDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFETEMQTAATSSSIEKSYELPDGQVITVGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMFPGIADRMQKEIVALAPPTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, nonmuscle.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PDXA_XANC8
Sequence: MVPSLALVPGEPAGIGPELCIRLAQQPRSDAHLIAYADPDTLHSAAKALCLSVRLLDPDQHARLPGDLPLHPVRQAAPTRFGTPDPANAAAVIAGLLGAAGDCLSGKLQGIVTGPVHKAVINAGGIAYTGTTELLAAQAGCPVVMMLANSIVRVALVTTHLPLRAVPEAITAEALARCLRITATAMQRDFGLEHPRIAVLGLNPHAGEDGLLGREELDVIIPVLDQLRSEGMQLIGPLPADTAFLPQKLTDFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAGRGVADPSSLLAATALCARLAARS
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LONF3_MOUSE
Sequence: MDSLQTAQMVSLSAELGSNNLELAEPEEPGTSAAAGQSAAHPEEVTPEGSQALGAQEPEQSLPLAVPTPLECKVLLTQADALASEGHLREALEVYRQLSERQQLVAEQLEQLVRCLADSVPQEELASDSSGTSSCCAAALKEAGEAAAVAPEVWDGFKCKKCHGFLSDPVSLWCGHTFCKLCLERGRAADRRCALCGVKLSALMAASGRARGPRRAGQPAPLQLRVNVVLSGLLGKLFPGPARASQLRHEGNRLFREHQVEAALLKYNEAVRLAPNDHLLYSNRSQIYFTLESHEDALHDAEIACKLRPMGFKAHFRKAQALATLGKVKEALKEFLYCVSLDGKNKSARSEAQRENLELPHCSNQEGAAAAEESSSLANSAQGKVSSKEDRKKDQEGEDRDAASVRTGKCQEKKRNRCQIETQEDTELPNKVSKQDFPAEQGAKPDLSNPLGSFDASDLECSLCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDVLLQCLPSRKYSKNVILEELIATFLPEEFKERKRLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFVEYGCILEIRNVQFFSDGRSVVDSIGKRRFKVLHQGQRDGYNTADIEYIEDQKVQGDDCAELMGLHNCVYEQASSWFHSLKASLKNRILNHFGPMPEKDEDPQVNPNGPAWCWWTLAVLPLESRAQLPFLAMRSLKDRLNGIRRILAFISRNQN
What are the official names of this protein?
LON peptidase N-terminal domain and RING finger protein 3, RING finger protein 127.
Protein: SYD_SHESH
Sequence: MRSQYCGDVNKSHVGQEVTLVGWVNRSRDLGGVVFLDLRDREGIVQVVYDPDLPEVFDVASTLRSEFCVQVTGLVRARPDSQVNKDMRTGEIEILGKGLTILNSAAPLPINMDKNQHNTEEQRLKYRYLDLRRPEMADRIVFRSKVTSAVRRFLDDSGFLDIETPILTKATPEGARDYLVPSRTYKGQFFALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFMSSAEVMAKTEEMTRGLFKDLLNVDLGEFPKMTFAEAMRRFGSDKPDLRNPLELIDVADILKDVEFKVFQEPANDPAGRVAVLCIPGGAKLSRKQLDEYAKYATIYGAKGLAWMKVNDLDKGLEGIQSPVLKFLNEDVVNGLLERTNAKTGDLILFGADKANIVAEAMGALRLKAGEDFDLLNGEWKPLWVVDFPMFEPTSDGGLHAMHHPFTAPMGITPEQLEADPTAAISDAYDMVLNGCELGGGSVRIHNSEMQSAVFRILGIEEEEANEKFGFLLEALRYGTPPHAGLAFGLDRIVMLMTGATSIRDVMAFPKTTTAACPLTNAPGFANPAQLVELGVNVIESEDNKEEQE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.