PharMolix/UniProtQA huggingface dataset:
Protein: ADRO_HUMAN
Sequence: MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
What is the function of this protein?
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
What are the official names of this protein?
NADPH:adrenodoxin oxidoreductase, mitochondrial, AR, Adrenodoxin reductase, Ferredoxin--NADP(+) reductase, Ferredoxin reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: MYOTI_MOUSE
Sequence: MFNYERPKHFIQPQNPCGSRLQPPGPEVSGFPSQTKQSSIVIQPRQCTEQRFSASSTVSSHITVSSSAYPAPQQLAGPNPGQKVTATYNQSPASFLSSILPSQPDYCNSKIPSTVDSNYQQSSVNQPVNAMSSQAANARPTPKTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDVQDSPQHNPEQARLHVPTSQVRSRSSSRAEANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLPAPDVSWYLNGRPVQSDELHKMIVSEKGFHSLIFEVVRASDAGPYACVARNRAGEATFTVQLDVLAKEHKRAPMFIFKPQSKKVFEGETVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYHDNAGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPIQTLPAPKQLRVRPTFSKYLALNGRGLDVKQAFNPEGEFQRLAAQSGLYESEEL
What is the function of this protein?
Component of a complex of multiple actin cross-linking proteins.  Involved in the control of myofibril assembly and stability at the Z lines in muscle cells (By similarity).
What are the official names of this protein?
Myotilin, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein.
What is the protein family that this protein belongs to?
Belongs to the myotilin/palladin family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma. Colocalizes with MYOZ1 at the Z-lines in skeletal muscle.
Protein: PELI1_HUMAN
Sequence: MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6.  Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297).  Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609).  Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609).  Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
What are the official names of this protein?
E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, Pellino-related intracellular-signaling molecule, RING-type E3 ubiquitin transferase pellino homolog 1.
What is the protein family that this protein belongs to?
Belongs to the pellino family.
Protein: T2EA_MOUSE
Sequence: MADPDVLTEVPAALKRLAKYVIRGFYGIEHVLALDILIRNPCVKEEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERNSTNRASFKCPVCCSTFTDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDRAATAAGAAGLAGGHHREAWTNKGPSYEDLYTQNVVINMDDQDDVHRPSLEGKAAKERPIWLRESTVQGAYSSEEMKEGGIDVDTFQEREEARAGPDDNEEVMRALLIHEKKTSSVTAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAAAPPHHHRDEDEEDEEFEEVADDPIVMVAGCPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE
What is the function of this protein?
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH.  Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
What are the official names of this protein?
General transcription factor IIE subunit 1, General transcription factor IIE 56 kDa subunit, Transcription initiation factor IIE subunit alpha, TFIIE-alpha.
What is the protein family that this protein belongs to?
Belongs to the TFIIE alpha subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TOM40_XENTR
Sequence: MGNVLAASSPAPPAAGSPPAPGLVSVPPGFTMPPVAGLTPTPDKKETQEDRLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNYFQVNHTVSLSMIGESNYHFGATYVGTKQLGPAEAFPVLVGDLDNSGSLNAQIIHQVTSNVRSKIALQTQQSKFVNWQLDTEYRGEDFTAAVTLGNPDILVGSGILVAHYLQSITPSLALGGELVYHRRPGEEGTVMSLAGRYTAPNWTATLTLGQAGAHATYYHKANDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLAMGAFLNHKKNKFQCGFGLTIG
What is the function of this protein?
Channel-forming protein essential for import of protein precursors into mitochondria.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM40 homolog, Translocase of outer membrane 40 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom40 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: PIAS2_MOUSE
Sequence: MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLCDLSTIKSSVFSLDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGRNIPDIISLD
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.  The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied.  However, it seems to be mostly involved in gene silencing.  Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.  Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation.  Isoform PIASx-alpha promotes PARK7 sumoylation.  Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity).  Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS2, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, Msx-interacting zinc finger protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2, RING-type E3 ubiquitin transferase PIAS2.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, PML body. Nucleus. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349).
Protein: PHOU_BURSP
Sequence: MIDKHLSSQFDADLESVCAQMLEMGRLVKMQVTDAMDALNHLDAQAAQRVMRNEQRINTLEIDIDQECSNIIVRRQPAARDLRLLMAISKIITDLERVGDEAEKIAVCTQRLTQAGAQPHLMDGSALKQAGAMAISMLHRALESFMHLDTAATAQIVRDDCVINEAFHAFVRTLITYMKEDTQMISTGLDYLSAAKAIERIGDHATNLAEFTIYIVKGTDVRHISPEQLAQEALC
What is the function of this protein?
Plays a role in the regulation of phosphate uptake.
What are the official names of this protein?
Phosphate-specific transport system accessory protein PhoU homolog, Pst system accessory protein PhoU homolog.
What is the protein family that this protein belongs to?
Belongs to the PhoU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_CAMJE
Sequence: MIISAKFITSLVKFDENLSSNFSEVAFLGRSNVGKSSLINSLCKQKNLAKSSATPGKTQLINFFEVICRRNEEKFNINFIDLPGFGYAKVSKNLKEIWNQNLDEFLKLRTSIKLFIHLIDSRHTHLEIDVNLNDYLKRFLRPDQKILKVFTKCDKLNQSEKAKLKNEFKDSILVSNLNKFGLDSLEDIIINQTLGLDK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: NPR22_CAEEL
Sequence: MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFEDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPATSLTRYSRSGVLDRQTCRSARFFEARPLVVVRNNSANSLA
What is the function of this protein?
Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior (PubMed:28847365).  Receptor for flp-7 which stimulates serotonin-induced fat loss (PubMed:28128367).  Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss (PubMed:28128367).  Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide (PubMed:16377032).  Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide (PubMed:16377032).  The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22 (PubMed:16377032).
What are the official names of this protein?
Neuropeptide receptor 22.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARLY_RIPO1
Sequence: MTKQKTWSDRFEGSLHPAIVEFNASIGFDIELIEYDLTGSIAHAQMLAHTGIISPEEAQKLTQGLEQIRQEYRQGEFKPGIDQEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDIRLYLRDQISQIRAQLREFQQVLVNHAENHIETLIPGYTHLQRAQPISLAHHLLAYFQMAQRDWERLGEIYARTNISPLGCGALAGTTFPIDRHYSAELLQFQGVYGNSLDGVSDRDFAIEFLNAASLIMVHLSRLSEEMILWSSHEFSFISLTDSCATGSSIMPQKKNPDVPELVRGKAGRVFGHLQGMLVLMKGLPLAYNKDLQEDKEAIFDGVKTVKVCLEAMTILLAEGIKFREERLAEAVSEDFSNATDVADYLAAKGIPFREAYNLVGKVVKTSSAAGKLLKDLSLEEWQALHPAFEADIYDAIAPKQVVAARNSYGGTGFEQIRQAITRAKAQLESS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_SHEAM
Sequence: MNNVLYIAAGGAIGAVLRYSISILALQLFGTGFPFGTLIVNVAGSFLMGCIYALAELSHIGPEWKALIGVGLLGALTTFSTFSNETLLLLQQGELVKASLNVLLNLILCLTVVYLGQQLIYSRV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RASA2_RAT
Sequence: MAAAAPAAAALTEAPAVPGTAEPETGDEDSREVRVLQSLRGRIYEAKNLLPYLGPNKMRDCFCTINLDQEEVYRTQVVEKSLSPYFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCSHSGKETWFSLQPIDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEVFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNENLVQDVFLGEIKVPVNVLRNDSSHQAWYLLQPRDNGNKSSKPDDLGSLLLTLCYTEDYVLPSEYYGPLKALLLKSPDVQPVSASAAYILGEICRDQKDAVLPLVRLLLHHNKLVPFITAVADLDLKDTQDANAIFRGNSLATQCLTEMMKIVGGHYLKVTLKPVLDEICESSKSCEIDPVKLKEGDNVESNKENLYYYVDKVFSAIVGSSVSCPTVMCDIFYSLRQMAAKRFPNNPHVQYSAVSSFVFLRFFAVAILSPHAFHLRPHYPDTQTVRTLTLISKTIQIIGNWGCQSRRKSRFKKSVMCEFLKMFQEERYFTDVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSKELTYHKQQGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKTLYIQANNCVEANEWIDMLCRVSRCNHNRLSSFHPSAYLNGNWLCCQETSEGTPGCKPCTAGIPADIQIDIDEDRETERIYSVFTLSLLKLQKMEEACGSIAVYQGPQKEPGYSKFTIEDSVATFKTIQQIKSTIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKIS
What is the function of this protein?
Inhibitory regulator of the Ras-cyclic AMP pathway.  May bind inositol tetrakisphosphate (IP4) and phospholipids.
What are the official names of this protein?
Ras GTPase-activating protein 2, GAP1m.
What are the subcellular locations of this protein?
Cell membrane.
Protein: PYRB_PROM9
Sequence: MQTIWPHKHIHTLANFSIQDYKSVFELAHRFDVLKNAGTKKIPALQGTLVTSLFFEASTRTKNSFELAAKRLSADVQTFAPSSSSLTKGETIIDTALTYSAMGADTLVIRHSSSYITFEIAKKLDAINAKTSVLNAGDGLHSHPSQGLLDIYTLIKFFSKKSLSPDVLNSKKILIIGDVNHSRVARSNLWALSAFGADIILCGPKTLIPDEFINFLKTPAPKQKEDPVKSRGSITISRSLEESIKIADAIIVLRLQKERMMENLLSSIDSYSLDYGLTPEKLSLNSKEIPILHPGPINRGIEITSKVVDEYPNCLINNQVANGIPIRMALLYLLQKYNK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: LDH1_STAA8
Sequence: MNKFKGNKVVLIGNGAVGSSYAFSLVNQSIVDELVIIDLDTEKVRGDVMDLKHATPYSPTTVRVKAGEYSDCHDADLVVICAGAAQKPGETRLDLVSKNLKIFKSIVGEVMASKFDGIFLVATNPVDILAYATWKFSGLPKERVIGSGTILDSARFRLLLSEAFDVAPRSVDAQIIGEHGDTELPVWSHANIAGQPLKTLLEQRPEGKAQIEQIFVQTRDAAYDIIQAKGATYYGVAMGLARITEAIFRNEDAVLTVSALLEGEYEEEDVYIGVPAVINRNGIRNVVEIPLNDEEQSKFAHSAKTLKDIMAEAEELK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate (Potential).  Appears to be the primary factor that allows S. aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity).
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRE1B_ORYSJ
Sequence: MDAAALQYENQKLVQQLEAQKSKMRALEGKFKELRDEQCSYDNTLICLNKMWNQLIDDLVLLGVRAGGDLNGLQALDHEEMSEESLESCPSEEIFLFRLLNSRNFRNNDDSSLSKLVEEALALRYSTTVTLMKSLQEAFAVQQARSESLSLALNGQNSSEDVIVALENHNDYLKEVVDNLRQAVSIINRKHEKYLDEIEAFKNNQSRELHEVKCLSGELEESMAELEESRRKLAVLQLQTGGGSLMNTSAPNGVNGSVSTDKSSDKGMGWRDLKDAVEEAKTLAANRLFELHETQEDNLILSKQLEDIQDQLKDENYIVTSKPYTILSDQLHHLNAEIERYRGLVEVLQNEKDQLMQKEEEMLAKAESVDAVQQSITTYKAKIEDLEHEIQKLMAEKNDLEIKAEEALQDSGKKDFKDEIHVMAASLSKEMELLDNQMNRSKDAASEALALREEADYLRTLLAKKIDEQKEISDRYNTQVTEIKSLKALIETLDQEKQELQFIVDMLGKECSESRAISEIEESENRARKQAEYLRKCLEEHNLELRVKAANEAETACQQRLSIAEAELEDLRAKVDASERDVMKLKESIRIKEAEVDGHISEIETIGQAYEDMQTQNQHLLQQVADRDDFNIKLVSDSVKMKQAYGSLLAEKNMLQKQLQHVNSSLESSKLKITSGEEQMKTYVAQAMKSSSENRHLAISLERTMLEVSDAEKELKWLRSATGSAEKEYEINQKKIAELKMELERERNERIKLEEEYEEVKNEVSELTSETEETTIQKLQDEIKECKAILKCGVCFDRPKEVVITKCFHLFCSPCIQRNLEIRHRKCPGCGTPFGQSDVREVKI
What is the function of this protein?
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1.  H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me).  It thereby plays a central role in histone code and gene regulation (PubMed:26143250, PubMed:26934377).  H2B monoubiquitination, mediated by HUB2, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1 (PubMed:26143250).  H2B monoubiquitination, mediated by HUB2, modulates transcriptional regulation of genes associated with flowering time and plant yield (PubMed:26934377).
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1-like 2, Flowering-related RING protein 1, Protein HISTONE MONOUBIQUITINATION 2, OsHUB2, RING-type E3 ubiquitin transferase BRE1-like 2.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CENPQ_SCHPO
Sequence: MEMKRRVRAVRRDQIQKRWRPLEDKQRQEIIIIFRTCSRLVLNTIKSETRKSLAEEWFMNILLKIEAPLRNLPVPRKRKESILFSQLLSSNMQLEQQLYSDLDHINVLQQELKVETARLENEQKSYEEMKQNMAINNSRLADLKSKLHPYLKKGLKISHDNFSDSNDFSFQKKLNTEDSNTSKTSTLDMYKEKLKPFTKTMQIHANKTVQLSQTIQKATLLLQRLNNTKNIGLNKSSKLKIKNI
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore.  COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit fta7, CENP-Q homolog, Constitutive centromere-associated network protein fta7, Sim4 complex subunit fta7, Sim4-mal2-associated protein 7.
What is the protein family that this protein belongs to?
Belongs to the CENP-Q/OKP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: OXLT_OXAFO
Sequence: MNNPQTGQSTGLLGNRWFYLVLAVLLMCMISGVQYSWTLYANPVKDNLGVSLAAVQTAFTLSQVIQAGSQPGGGYFVDKFGPRIPLMFGGAMVLAGWTFMGMVDSVPALYALYTLAGAGVGIVYGIAMNTANRWFPDKRGLASGFTAAGYGLGVLPFLPLISSVLKVEGVGAAFMYTGLIMGILIILIAFVIRFPGQQGAKKQIVVTDKDFNSGEMLRTPQFWVLWTAFFSVNFGGLLLVANSVPYGRSLGLAAGVLTIGVSIQNLFNGGCRPFWGFVSDKIGRYKTMSVVFGINAVVLALFPTIAALGDVAFIAMLAIAFFTWGGSYALFPSTNSDIFGTAYSARNYGFFWAAKATASIFGGGLGAAIATNFGWNTAFLITAITSFIAFALATFVIPRMGRPVKKMVKLSPEEKAVH
What is the function of this protein?
Anion transporter that carries out the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation, at the plasma membrane, and in doing so catalyzes the vectorial portion of a proton-motive metabolic cycle that drives ATP synthesis.
What are the official names of this protein?
Oxalate:formate antiporter, OFA, Oxalate:formate antiport protein, Oxalate:formate exchange protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. OFA (TC 2.A.1.11) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYC_BURP0
Sequence: MESLRIYNTLARDKQDFVPRQPGEVRMYVCGITVYDYCHIGHARMVVVFDIVQRWLRARGYRVTYVRNITDIDDKIIRRAVENGETIQSLTRRFTDAMNADFDALGVERPDLEPRATEFIPQMLGMIEKLEANGYAYQAKDGDVNYSVRKFANYGRLSGKSLEDLRAGERVAANDAKEDPLDFVLWKRAKPQEPAGASWESKYGAGRPGWHIECSAMGCTLLGAHFDIHGGGQDLQFPHHENEIAQSEGATGQTFVNYWMHNGFVQVDSEKMSKSLGNFFTIREVLEKFDAEVVRFFIVRTHYRSPLNYSDVHLDDARASLTRLYTALKDATPDAQPLDWSEAHAQRFAAAMNDDFNTAVAVAVLFELATEVNRTREPALARQLRLLAGLLGLLGREPREFLQHAAGAARTGALEPHEIEARIAARVAAKQAKNYAEADRIRAELLEAGIALEDKPGGSTEWRRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGAL_CLOP1
Sequence: MKNYGPISSKVTKMLHGADYNPEQWIDMPNIWGEDVRLMKLSHTNVVAVGIFSWTMLEPEEGKFNFEWLDEIMDLMHKNGNYVILATPSGAKPIWMAHKYPETLRVAQNRVRNLYGERHNHCYTSPIYREKIAIIDRLLAERYKDHPALILWHISNEFEGQCYCPLCEEAFRDFLREKYDNDINKLNKAWWTKFWSHTYASFDEIEAPAPHGEPALHGLNLDWMRFVTHQTLDYYKHERSILKEITPDIPVTTNFHDYISLFRGIDYWKFAPYLDVVSWDNYPYWHGERTDDHEGSRIGFVHDLNRAILNGKPFMMMESSPSSTNWQPVAKLRRPGMHVLSSLQAVAHGSDTVQYFQWRKSRGSSEKFHGAVVDHCGHENTRVFRDVTKVGEILSKLDDVIGTSVEPQVAVIYDWENYWAINDAQGPRIEQKDYFETCQKHYKAFWDMSIPTDVINMDCDFSKYKVVVAPMLYMVRPGVGERLEEFVKNGGTLVTTYWSGIVDENDLCFLGGFPGPLKKVTGIWAEELDALYDEDVNYVSVEEGNSLGMKGEYEARIFCDLIHSEGAEVLATYKTDFYKGMPALTCNNFGEGQAYYIAFRNNDEFLSDFYSSLAKKLTLKRAIEIDLPKGINAQVRMDEKNEFVFFMNFSSEEKTIDIKDLDLTDMVTGEKVAKEMEIEPYGVRIVRRK
What are the official names of this protein?
Beta-galactosidase Pbg, Beta-gal.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 42 family.
Protein: Y048_YERPB
Sequence: MDEWYGQVAPREKLLKYGAAVLTDAELLAIFLRTGIPGMHVMKMAEYLIETFGSLHGLISADYQTLCAHKGIGASKYSQIQAIGELACRCFSSHLMRESVLLNPGITQKFLQNILSHREREIFLVVFLDNQHRVIRHEEMFTGTISSVEVHPREIVREALKVNAAALILAHNHPSGKAEPSQADRLITTQVIKACSLLDIRVLDHLVVGRGECVSFAERGWL
What are the official names of this protein?
UPF0758 protein YPTS_0048.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: RL24_TRIV2
Sequence: MPSKKDTTPKFHKLHVKTGDTVQVIAGKDKGKVGEVIKALPQLSKVIVKGVNIKTKHVKPQQEGESGRIVTQEAPIHSSNVMLYSTKQNVASRVCYTFTAEGKKVRKLKKTGEILDN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RL20_BARQU
Sequence: MARVKRGVVAHAKHKKVLKQAEGFYGRRKNTIRAAKAAVDRSKQYAYRDRKNRKRIFRALWIQRINAAVRAEGLTYGRFIDGLSKAGIEIDRKVLSDIAVHESAAFSALVASAKKALEYLRDTTSNAFEGAVK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: QUEF_AGRRK
Sequence: MPKTDVSGLSMLGNQTETAANPEVAVLEKVPAGYAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYVPNEWLVESKSLKLFLHSFRNHGAFHEDCSIYIAKRLVELLEPKWLRIGAYWYPRGGIPIDVFWQTGKPPEGVWLPDQGVQPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.