PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_STRR6
Sequence: MSRILDNEIMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TIMP4_MOUSE
Sequence: MPWSPLAALSWALVLRLLALLWPPGRGEACSCAPAHPQQHFCHSALVIRAKISSEKVVPASKDPADTQKLIRYEIKQIKMFKGFEKAKDIQYVYTPFDSSLCGVKLETNSHKQYLLTGQILSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHQNCGCQITTCYAVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGICSWYRGHLHLRKEYVDIIQP
What is the function of this protein?
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
What are the official names of this protein?
Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HOLIN_BPT5
Sequence: MVLVRGGYKLEKFLQLLTVLLQEAKDPASLLKRLLTILVAVIIFLFVSNTSEVMSFLKTFSTSAVLQDVQTQRIDNFPNVAREKSMVLFSQTGADAVFVVKYKPDAINDYSNIIAWESNAQLDRADLADKAVNKTSELYRRHLEGFNYASDLTVKVNKYMGKNIPSFKNVIFNYIYTCPYFNLNNIYAGYIGIAWRDKPVDIADSEQFKEYLTKLCSPQQRSLGRSI
What is the function of this protein?
Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space.  Determines the precise timing of host cell lysis.  Regulated by specific antiholins that somehow sense superinfections and then delay lysis.  Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
What are the official names of this protein?
Holin.
What is the protein family that this protein belongs to?
Belongs to the T4likevirus holin family.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Classified as a class III holin.
Protein: PHS_HYPEX
Sequence: MDPRLTHEDRILHLAPLTEKGWLLVEGRDAIHKEFKFKDFNAAFGFMTRVALLAEKMDHHPEWFNVYNKVQITLSSHDVAGLSQRDIKLASFIEKAAVGASTS
What is the function of this protein?
Involved in tetrahydrobiopterin biosynthesis.
What are the official names of this protein?
Probable pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: UBIA_SHIBS
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNH_LACP7
Sequence: MKVTIYTDGAARGNPDGPGGYGTILSYIDSTGVEHIREYSGGYKKTTNNRMELMAAIVGLEALTKPCVVTLYSDSQYVVKAFNEHWLDGWIKKGWKRGKNEPVKNVDLWKRLLAAKNQHDVTFCWVKGHDGHPQNERCDVLATTAADGGNLADDNVVE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_METFK
Sequence: MSRTLELAKDLIARKSVTPDDAGCQELLISRLEPLGFSIERLRFGDVDNFYARRGNTGPLLVFAGHTDVVPTGPVAQWHTPPFTPTVKDGMLYGRGAADMKTSLAAFITAIEAFVADHPDHPGSIGLIITSDEEGVAINGTVKVVETLKARNELIDYCIVGEPTSSKVVGDMIKNGRRGSLSGKLTVKGIQGHIAYPHLVKNPIHMAAPAIKELSETIWDEGNEYFPPTSWQISNIHGGTGATNVVPGEVEILFNFRFSTASTAENLKQRVHAILDRHQLEYDLAWELSGKPFLTPRGSLVTAISSAIDQAFGVTPALSTSGGTSDGRFIADIAGQIVEFGPLNATIHKLNECVAVADIEPLRRTYQLTLEALLK
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: MINE_XANCP
Sequence: MGLLDFLKSKKNTAETAKNRLQIIIAQERNHRGGPDYLPLMQRELLEVIKKYVNIDADAVRVDLVKDGEHDVLDITVALPEDGDK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: CA131_RAT
Sequence: MAAERELDSSELPGSEALLDAVLRTLYDLGETEGETEQKRTRKKKEKKRDSETVADRAAEPLPLPASPGRDQRKSASSFFKKLREELQSAPAAPSEVPAATTAVSLFPLENDSKLVEVVEFHSRSEKRKPKSEEDKPAKNKTKVLEKDVVIQEFNLEKARLEVHRFGITGYGKGKERVLERERAIMLGAKPPKNTYVNYKVLQEQIKEKRTSMEEEKRAAQETDIFKRKKRKGRSQEDRRSKKLAPSILSSGRAAQVGKFRNGTLILSPADIKKINSSRVSK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Prevents helicase DHX37 to be recruited before post-A1 state.
What are the official names of this protein?
Uncharacterized protein C1orf131 homolog.
What are the subcellular locations of this protein?
Chromosome.
Protein: HXB2_SALSA
Sequence: PGRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKLWFQNRRMKHKRQT
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B2, S6.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Proboscipedia subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPD_SHESH
Sequence: MNDSQDKIVAIVPAAGIGSRMGAEIPKQYLLIDEKTILQLTLELLLTHPKIDCVVVALHPEDQFFKGLPLSSHHKLHTVVGGSERADSVLACLNHLGGDCWAMVHDAARPCLTHGDIDKLIASRQRFPQGAILAAPVRDTMKRGNADGTVKETVCRERLWHALTPQLFPAALLKGNLEQALAQGANITDEASAMEWAGVSPGLVDGRVDNIKITHPDDLLLAGLFLGNAHSLER
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RNAS1_SUNME
Sequence: MGLENSLILFSLLVLVLGWVQPSLGKESSPDKFKRQHMDTEGSSKSSPTYCNQMRSPQEMTKGSCKPVNTFLHEPLEDVQAICSQDKVTCKDGKSNCHKSSSTLHITDCCLKGSSNYPKCNYTTTESQKHIIIACDGNPYVPVHFDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: KPTA_BACHK
Sequence: MNKQKFYTNLSKEVSYALRHAQWKYELELDENGWVSVEQLLHALHQSIEWRDVKIEDLKIMIEKSEKKRHELKENKIRALYGHSIPMKIVKEEGVPPEFLYHGTSPRFLNSIESNGLSPMSRQYVHLSEDIITAELVGKRKDKHPIILEVNTGKAREEGVKFYLGNEKVWLADEIPSEFIAINKN
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: NU159_CHATD
Sequence: MAFSFGNAGGGGGGVTQGKDLEVIQTEGLGFLALAGDAKVQLTSKWSPPPAPTASLLSIASRKGLVAAAGPDAVHVATTESVRKAFLAEKNGDSEVRPFNPEAKLPLPLRISQLAFTADEQYLVLSAETGGGLRAYDVNSLTQGNTQSAFELATNGETLRQLAPNPMPESAAFCAIVTTNGNLYMANLAERTLVSGPNGPTLRSQVSCAAWSTKGKQLVAGMADGSIYQMTPDGTEKAHIPKPPNLGDYHVSSVVWLENNVFLTIHNPTNSTNPDDKTVYHVITRQQSSGSPPNFTFQKLNDPVEPFVADKTPHHTVLRLKDFPPNLQDLLLVSSTAVETIGLLTRSKTPLATDKPADAITNVFTTTELADDSRRAQLPMSEDMMETYPIGVALDLSSKEKVYKPIPTDEEIEYSPGPLPGLWVLNNEGVLASWWVVYNESIRAGTTYSGIGGSSEVIPASPAPALASSTAPVPAFASPVSKPTFGSPSPATPAFGGPSALGTKASPWATAGGAASSTPTFGQPSFGKPAAPAFGQASFPGLGQKVSPWATGSTTSAAPAFGQSGFASAGTAPGKVFGSSFTAPSSGGFASFATKSGFASLSAPSGGSSIFSSKPGAPLTSAAPEVSMDTDTAFPPPSTKTDKPAFGSSPFVLGSTFKADPTAAHDIEKPKEGESKSLFDTGFGLSLEDAAKQPASAAESKDEEMRSTTPPLPPPTETKPKSIFESTTPTTTPAPQKFEFKTTTPSGFSTLLGSTKPVASSMPNIFATPKPTSAEKPKSIFDTLKPKEESKENLLKASEPPLPPDTTSKAVFQPGSSSSESAESSPGAAAKAAFKVGNDETPKPQKELAPKPEAVPLPPDFVKAKPKTEAKETKAEEPAVSPNLPVKPLAKKAEPIPAVPESASEEEQGQAEEEEAESGEEEEEEEEEGEGEEEEEEEEEEEEEEEEGEEGEEQSEAGSEGSGVDVAKDLSPTAKFGSMTPGYTPHTSLGGMAESTFSTISRSEVAEQSRPLFGEITKNAPPLFPAAGPLPVSPRSPSPVRGVVRSSILRPTETPRPVDTTPVPSRKGLLQKTASFGMSTGQKPAVDPNVKAQRKLAEKLKAEEQVLVDPEDEGIQQILQSKVEPTLRMNEFLAVDTKLAPMKPGRDDVPNACETLWRDINRMIDRLGLNSRSLQSFILGHTSHGKPGGRQKDDLEKPDDWVLIEAYDLGDMIDNKLARELEAGRIKDVEGTMAAIHNLGRDLAKLRAKEEDLRKLFNAQVDPDQIALTKALPLSAEQLAQQNELRRSYASFSKLLTEAEEALTVLKAKLASANAARGRRGAGAAQVPTVDAIIRTINKMTSMAEKRSGDIDVLESQMRKLRIGSLGPAGTPNGNGVGAGTVVPATPGGGGRSRESSPFVTPQSSRRAMFMSPGSVGTATPRGLLAATGTPSPTKKKLSMYTAEEKRELRAREAKRKATLRMLRESLARVGPNVVRLRDDD
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).  NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre-ribosome, and protein export.
What are the official names of this protein?
Nucleoporin NUP159, Nuclear pore protein NUP159.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UBP11_CANLF
Sequence: NSARADLCVALAKHTGMSPERMMVADVFSHRFYKIYQLEESLSSILDRDDIFIYEVSGRSAIGENSREDVVLPIYLRERTPARDYNNSYYGLMLFGHPLLVSVPRDRLSWDALYHILLYRLSRYVTRPSSDDEDDGDEKDIEDKDNIPKPGHVAGASSQDSGAGSGGAQLWSRRRKPAPVDNSPGPSHWPQRARRKHLFTLQTVNSNGTSDRSTFNEDTHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVLKKAPVRLQECIELFTTVETLEKENPWFCPTCKQHQLATKKLDLWMLPETLIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIKPQNESAPELYKYDLIAVSNHYGGLRDGHYTTFACNKDSGQSDYFDDNSVSPVTENQIESKAAYVLFYQRQDVARRLQPQPSSSDPPASPACGSPPNSEFMDVN
What is the function of this protein?
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains.  Inhibits the degradation of target proteins by the proteasome.  Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains.  Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro).  Plays a role in the regulation of pathways leading to NF-kappa-B activation.  Plays a role in the regulation of DNA repair after double-stranded DNA breaks.  Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.  Promotes cell proliferation by deubiquitinating phosphorylated E2F1.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 11, Deubiquitinating enzyme 11, Ubiquitin thioesterase 11, Ubiquitin-specific-processing protease 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=Predominantly nuclear. Associates with chromatin.
Protein: CCME_PSEPG
Sequence: MNPQRKKRLLLIVGLLVGVGVAVGFALSALQQNINLFYTPTQIANGEAPLDTRIRAGGMVEKGSVQRSSDSLDVRFVVTDFNKSVPITYRGILPDLFREGQGIVALGKVNADGVVVADEVLAKHDEKYMPPEVSKALKESGQAATGGEAKP
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: ACEK_AERS4
Sequence: MQQPLEQAVAETILQRFESFYSRFLEITQGSKSRFENSDWLGVQLAGRERIRLYDHHVGATTALIKQMMGEHHATQELLKRVKGAFSDLLPRCDNFEVAESFFNSVYRRIFRHRNIRDENLYIHPFRSRGEHPDLSALLRVYRTDLTHLPQTLSQMLGDYSFTLPYEDKQRDIVDIHRHLAENGPQILHEEPFAIELLKEVFYRNKGAYLVGLIRVKGQVFPFILPLLSTGQSIYVDTVIFEPELASIVVGFARAYFMVYAPVPALFVVFLRQIMPHKPDYEIYNAIGCQKHGKTELYRHYQQHLAQSREQFVIAPGIKGMVMSVFTLPSYDVVFKVIKDEFTPPKDVSHEQVRAKYRLVKQHDRVGRMADTQEFTNFEFPLDRISPELLAELKTVAPSALTITSDKLVIKHLYTERKMIPLNLYLDKADEQQTRLALEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTECNFRQIPPPRYPEDEWSAEPWYSVAPNDIFPEEFATFLLQKPQVREIMMQLHKEMFDANYWKMLQSNIKVGVFEDVYPYRRKKRFKFQRGG
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFS1_CAEEL
Sequence: MDPSENVFKYETAYDLLVRLGAERLFLRTCLSILDPVLELHPGKCYEIDGDLGVGKTQICYSFAAKFLQTKKTAKMGWIGATPLRTDHLLLHIEHFGNQTNEDILDRIVCKRVEKIAELQDSLTRFLDTINLQLVIVENIDAILHDTVYHKEMGRSMQSDVVERIRKLTKLEITVILTNHITHWRGYPAPALGAFWSSQINNRFFIEKRNDDSDIRIVSAMKGEQDDGMNRIEFKIGDRGLKAVE
What is the function of this protein?
Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis.  Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers.
What are the official names of this protein?
RAD51-like protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALGC_PSEAE
Sequence: MSTAKAPTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPCVAVGRDGRLSGPELVKQLIQGLVDCGCQVSDVGMVPTPVLYYAANVLEGKSGVMLTGSHNPPDYNGFKIVVAGETLANEQIQALRERIEKNDLASGVGSVEQVDILPRYFKQIRDDIAMAKPMKVVVDCGNGVAGVIAPQLIEALGCSVIPLYCEVDGNFPNHHPDPGKPENLKDLIAKVKAENADLGLAFDGDGDRVGVVTNTGTIIYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGRPVMWKTGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQDQRDSEHVFSAFPSDISTPEINITVTEDSKFAIIEALQRDAQWGEGNITTLDGVRVDYPKGWGLVRASNTTPVLVLRFEADTEEELERIKTVFRNQLKAVDSSLPVPF
What is the function of this protein?
Highly reversible phosphoryltransferase.  The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics.  Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity.  Essential for rhamnolipid production, an exoproduct correlated with pathogenicity (PubMed:10481091).  Required for biofilm production.  The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-108 to the substrate (generating a bisphosphorylated substrate intermediate and a dephosphorylated enzyme), a 180 degree rotation of the intermediate (probably aided by movement of domain 4), and subsequent transfer of phosphate back to the enzyme (PubMed:11716469, PubMed:16880541, PubMed:16595672, PubMed:22242625).
What are the official names of this protein?
Phosphomannomutase/phosphoglucomutase, PMM / PGM.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RS14_OPITP
Sequence: MPKTSAIERNKKRIRLAAQHAAKRAELKAILANPATTDDEFFGAQKKLQKLPKNSNKIRIRNRCSLSGRPRAYIGKFGVSRIQFRELALAGKIPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RIMM_ECOLU
Sequence: MSKQLTAQAPVDPIVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDMIIKLKGVDDRDAANLLTNCEIVVDSSQLPQLEEGDYYWKDLMGCQVVTTEGYDLGKVVDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLTTRSIEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_ACTPJ
Sequence: MSMQDPIADMLTRIRNGQAANKVAISMPSSKLKVAIASVLAEEGYVESFKIVEGSKPELEITLKYFQNKPVVESIQRVSRPGLRIYKRKDELPKVMGGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SYL_THEKO
Sequence: MAELNFKAIEEKWQKRWMEARVFEPDRKAKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGAPIVGIAERIKNRDPKTIHIYRDVYKVPEEILWKFEDPKEIVKYFMKAAKETFIRAGFSVDWTREFHTTSLFPPFSKFIEWQFWTLKDMGLVVKGAHRVRWDPVVGTPLGDHDIMEGEDVQILEYVIIKFILEENGETIYLPAATLRPETVYGVTNMWLNPEATYVKAKVRKGDREELWIVSKEAAYKLSFQDREIEVIEEFKGEKLIGKYVKNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHIALEDLKKETEILLKYDIDPRVVEEISYISLISLEGYGEFPAVEEAERLGVKSQKDKEKLEQATKNIYKAEYHKGIFKIEPYAGKPVQEVKELVAKEMMEKGIAEIMYEFADKPVISRFGNQAVIKIIHDQWFIDYGNPEWKAKAREALANMTIYPESRRAQFEAVIDWLDKKACARKVGLGTPLPWDPDWVIESLSDSTIYMAYYTISRHINQLRKEGKLDAEKLDREFFDYIFREPFSEEKERKLSEKTGIPAETIHEMKEEFEYWYPLDWRCSAKDLIPNHLTFFIFNHVAIFDKKHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMGLAEHDSDFDWRRKEVGKLRKQVERFYELVSEFATYEAKEGVELKDIDRWMLHRLNKAIEGATKALEEFRTRTAVQWAFYTVLNDLRWYLRRTEGRDDDAKRYVLRTLADVWVRLMAPFTPHISEELWEKLGGEGFVSLAPWPEPVPEWWNETVEAEEDFVKSLIEDIKEIITVAKIENPKRAYIYTAPEWKWRVVEVVAEKRDFKAAMAELMKDPEMRKHGKEVSKLIQRLIKERAFEVKRIDEEKALREAKDFIEKELGIEIIINPEEDRGGKKKQAMPLKPAVFVE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGP_METKA
Sequence: MTSLVITDIDGTITGDDRAVHLKCIRYLRELQKRGIPVGIATGNTLCYSRSAATLLGFEGPLIAENGGIVAVDDEEISTVPEEDIELIQEAYRELRRRLGVRRTEPPGLRRTEVAIYRDVPIEEVERVLDGLGYSGRIEVVDTGFAYHLKSKRVDKGKGLLVICERLGIDPDDVVAIGDGDNDAPLLKAAGLGVAPANATENVKRIADVVLDAENGEGVATFLRKLLEEVDA
What is the function of this protein?
Catalyzes the dephosphorylation of 2-phosphoglycolate.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the archaeal SPP-like hydrolase family.
Protein: RL24_BACAA
Sequence: MHVKKGDKVQVITGKDKGKQGVILVAFPKQNRVIVEGVNIVKKHSKPSQLNPQGGIITKEAPIHVSNVMILDPKTGEPTRVGFKVEDGKKVRIAKKSGELLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.