PharMolix/UniProtQA huggingface dataset:
Protein: CARD_GIBF5
Sequence: MAANNLSYTIAPLEHTPLDEIAAKVDLVRKTFRSGRTKDMEFRMKQIRKLYWAIVDNTELMQDALIKDLRKCKYEAVLAEIDWCKQECIDMVNNMEKWLRDEPVPNVPLQFRAMKHRTRFEPLGVVLNIGSFNFPFQLNLPVVIGAIACGNCVVLKASESSPNCAMVLKKIFDESLDPECFTYVNGALPETQLLLEQKFDKICFTGGKAVGKIIAQKAAETLTPVLLELGGLNPAFVTKHANLKLAARRLLWQKSLNAGQVCMSHNYILVERSVLSQFLGELNNQMRTFFPQGAKNSPDLCRIVNAGHFNRLKKMLDGTNGKIVLGGSMDESTLFMEPTAVLVDDINDSMMTQEAFGPIFAMMAVDSLDQAIDIANTVDPTPLSLSAFGSKAENNKILDNVTSGGATCNDAFFHSQIPQSPLGGVGQSGMGNYHGIYSIRTFSHQRTIAEVPYWADFLFRVRYMPYQWPVMNRMKAVADSKPNFDRNGNKTKGITYFLALVLGLGSKKSKGALLRWAVLVVAAAILEAKKGVLSQLLTR
What is the function of this protein?
Beta-apo-4'-carotenal oxygenase involved in the last step of synthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:21749649).  Converts the aldehyde beta-apo-4'-carotenal into neurosporaxanthin (PubMed:21749649).  Is also able to use shorter apocarotenals as substrates (such as beta-apo-8'-carotenal (C30), beta-apo-10'-carotenal (C27), or the acyclic apocarotenal apo-8'-lycopenal (C30)), indicating wide substrate specificity (PubMed:21749649).  Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities.  Phytoene synthase activity performed by the bifunctional enzyme carAR first produces phytoene from geranyl-geranyl pyrophosphate (GGPP).  The phytoene dehydrogenase carB then introduces 4 desaturations to lead to lycopene which is substrate of the carotene cyclase activity of carAR that leads to the production of gamma-carotene.  CarB then performs a 5th desaturation reaction to yield torulene.  Torulene is the substrate of the dioxidase carT that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase carD mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
What are the official names of this protein?
Beta-apo-4'-carotenal oxygenase, Beta-apo-4'-carotenal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CYB_SOUCH
Sequence: MTNIRKTHPLMKILNDAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGALLLILTLLALTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILIFIPMLQTSKQRSMMFRPLSQLLFWTLIADLLTLTWIGGQPVEHPYIIVGQLASILYFLLILVLMPTAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEC_STUS1
Sequence: MNEKKAVILLSGGLDSATVVAMARDEGYACYTMSFDYGQRHRAELQAAERVAKQLAVVEHKVIGLNLNGIGGSALTDTSIDVPEAPSEGIPVTYVPARNTVFLSLALGWAEVLGARDIFIGVNAVDYSGYPDCRPEFVAAFERMANLATKAGVEGQGFRIQAPLQNLSKAQIVRKGSRLGVDYAMTVSCYQADDDGRACGKCDSCRLRSAGFAEAGLADPTRYF
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RQCH_BACSU
Sequence: MSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAKGKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIMIFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLPGQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAGLANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELLDRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELLTANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVVEEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNPVLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQTIMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTVIKLKKS
What is the function of this protein?
Part of the ribosome quality control system (RQC).  Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail).  The Ala tail promotes nascent chain degradation.  Selectively binds tRNA(Ala)(UGC), which is presumably the sole source of tRNA(Ala) used for Ala tailing directed by this protein.  May add between 1 and at least 8 Ala residues; detection of the Ala tail requires either deletion of clpP or its inhibition.  Binds to 50S ribosomal subunits, at least 30% of which contain a P-site tRNA and thus are obstructed.
What are the official names of this protein?
Rqc2 homolog RqcH, RqcH.
What is the protein family that this protein belongs to?
Belongs to the NEMF family.
Protein: HSLO_AZOVD
Sequence: MSDFDFTQRFLFDDTDVRGELADLRGSYAEVLAKHPYPEPVAQLLGEMLAAAALLVGTLKFDGLLVLQARSPGPIPLLMVECSSEREVRGIARYHAEQVEPGAGLRELMPEGLLTLTIDPRRGQRYQGIVELRGESLADCLSGYFADSEQLPTRFWLNADGRRARGLLLQQLPADRLKDAEARTLNWEHLVTLADTLTAEELLGLDNETLLRRLYHQEAVRLFEPLPLRFRCSCSRERSANALSSLGQADAEQLLRERDGLVVVDCQFCNQRYEFDATDIAQLFAGGGSGAPSATRH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MP17L_BOVIN
Sequence: MVSWWQALTRAAGRYPWPANVLLYAGFFSGGDALQQVLRGGPADWQHTRHVATVAVAFHANLNYVWLNLLERALPGRAPRTILAKVLCDQALGGPVYVSTFYAGMSILQGKDDIFLDMRQKFWNTYKSGLMYWPFVQLINFSLIPIRWRTAYTGLCGFLWATFLCFSQQEGDGTFKSAFTFRRIKVTNEVEKPSEK
What is the function of this protein?
Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.
What are the official names of this protein?
Mpv17-like protein, M-LP homolog, M-LPH.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: RL2_BUCA5
Sequence: MAVVKCKPTSPGRRHVIKVVNNELYKGKPYSLLLRKKSKSGGRNNNGRITTRHIGGGHKRAYRIVDFKRNKDDIGATVERFEYDPNRSSNIALILYKDGERKYILAPKGIKIGDTIISGLRAPIKTGNTLPLKNIPVGTFVHNVELKPGKGGQIARSAGSYVQLVAFDEEYATLRLRSGEMRKTQSNCRATIGEVGNSEHMLKVLGKAGASRWIGIRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGIQTKGKKTRKNKRTDKFILRHRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RS18_DICDI
Sequence: MSSSLVFQGEFQHIIRIYNTNVDGRRKIQYALTCVKGVGRRFANLVCKKADIDTSKRAGELSKDEVERLTTIMNHPRQYNIPTWFLNRQKDIKDGKYSHCLANQIDVKFREDLERLKKIRAHRGVRHHFGLRVRGQKTKTTGRRGRTVGVAGRR
What is the function of this protein?
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
What are the official names of this protein?
40S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_LACPL
Sequence: MVKQTTEMNDASYLFNTGAGFNSQDYLGCHLAASGRAVFRVWAPHAKAVGVVGDFNDWQPSALKLLGATGIWQGQVPNVHAGQLYKFQITTPTGQVQLKIDPFAQQFERKPGDAAVVVEPMTMRWHDSLWLARRKKSRAANRPINIYEVHLGSWRRHLDGSYYTYAELAAELIPYVKQRGYTHIELMPVMEHLLDASWGYQQLGYFAPTSRFGKRDSFLSFVDQCHQANIGVFVDWVPGHFIRNYDALYQYDGTPTFEYADPERANNRRWGAWNFDLGKTQVQSFLISSAEYWLDQCHLDGLRVDAVSNMLYCDYDEGREGQVNQYGDNRNLEGIAFLQKLNTTVLTHHPDILMIAEESSAYPQVTGSVANGGLGFNYKWNMGWMHDTLDFFMMDPLYRHDHFNLLTFAFVYMFDERFILPFSHDEVVHGKKSLMHKMSGDRYNQFANLRTMLTYMAAFPGKQLNFMGSEWGQFLEWRDWSALEWVDLKDDLNHRMQQFTTQLNAVYRHNRPLWEQDHDPAGIIYTHTDDPDSSTMGFIRQAKRKYSFVVAAFNFVPVERQDYRIGVPYRGRYELLLNTEAQAFGGTWTKLETTFTAVDKPYRGQPASFTVTLPAMGALLIRPVKVIGGVKHAR
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: PYRF_STRZP
Sequence: MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAGPEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKVLSQLGVDMTNVHAAGGVEMMKAAREGLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEVQVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPVAAYHAIKDEWTQDWN
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CSA1_THETK
Sequence: MLTLLEIARLLRRAKVTQGPAEVSPELRGWAYDRQPVKPPAYLGLALSDFAYGYCPTGRSLYLKYVLGERPQPTKPLAEGQALHAVLFKALEDFRRYVYSGAPMSPPGEGMPEDLRAKAEALYRYIAVRLTGEYQYVLASRLARSRDAAAFYAAPIAAQIAVDGAPLGLSYVVADGVALGAVVEFKFGPSQNVDVALAGYAMAIEAEYGVPIDYGIHVQIAVDGQVEYRASAYVLGDAPRAKFLEARDEAIDVVASARDPGPAPQCPKTCPYYSVCRS
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).  A ssDNA exonuclease with 5' to 3' and perhaps 3' to 5' activity.
What are the official names of this protein?
CRISPR-associated exonuclease Csa1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Csa1 family.
Protein: YCEH_ECO5E
Sequence: MKYQLTALEARVIGCLLEKQVTTPEQYPLSVNGVVTACNQKTNREPVMNLSESEVQEQLDNLVKRHYLRTVSGFGNRVTKYEQRFCNSEFGDLKLSAAEVALITTLLLRGAQTPGELRSRAARMYEFSDMAEVELTLEQLANREDGPFVVRLAREPGKRESRYMHLFSGEVEDQPAVTDMSNAVDGDLQARVEALEIEVAELKQRLDSLLAHLGD
What are the official names of this protein?
UPF0502 protein YceH.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: GLGB1_XANC8
Sequence: MTNRWDPGVTRALAEARHGDAFAVLGAHPSTNGRLLRTYHPGAEHVTAVLADGREVPLEAGPEPGLFAGELPAEGRYRLRIGWPGGTQDTADPYAFGPLLSDFDLHLISEGHHLQLADALGANAVEVDGVRGTRFAVWAPNASRVAVVGDFNSWDARRHPMRLRHQAGVWELFVPDVGPGAHYKYQLRGPHGHELPAKADPVARRAELAPGTASIVADPTPHQWSDDGWMATRARRQAHDAPMSIYEIHAGSWLREEGLDLDWDGLADRLIPYVADMGFTHVELMPVTEHPFGGSWGYQPLGLFAPTARFGSPDGFARFVDRCHREGIGVIVDWVPAHFPTDAHGLAHFDGTALYEHADPREGFHRDWNTLIYNHGRREVSGFLIASALEFLQRYHVDGLRVDAVASMLYRDYSRNAGEWVPNIHGGRENYETIAFLRRLNEVVREHAPGAVTIAEESTAWPGVTADVSHGGLGFHYKWNMGWMHDTLHYIGLDPIYRRYHHGELTFSMVYAYSERFVLPISHDEVVHGKGSLLGRMPGDDWQRFANLRAYLGFMFTHPGRKLLFMGCEFGQPTEWNHDAGLPWHLLDDARHRGVQTLVRDLNHLYAQYPALHAHDDDPSGFAWLVGDDAANSVVAFLRKGKRGDAPVLVVINYTPVVQQGYRLGVPQGGLWREVFNSDAGIYGGANLGNGGAVTAEPQSMHGHAQSLPLLLPPLGVIVLAPQG
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB 1, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 1, Alpha-(1->4)-glucan branching enzyme 1, Glycogen branching enzyme 1, BE 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: GATB_LEGPC
Sequence: MEWDTVIGLEVHAQLKTKSKLFSGASTAFGATPNSQTSFIDAGLPGVLPVLNEQAIIMAIQFGLAIHGTINDLSVFERKNYFYSDLPKGYQISQYQKPIVTNGYLNIQLGNNLEKTVHIARAHLEEDAGKSLHDAHTDYTGIDLNRAGTPLLEIVTTPCLHSAEEAINYLKTLHQLVRFLGICDGNMQEGSFRCDVNLSIKPKGSSVLGTRTELKNLNSFRFIEKAIAFEQARHQDILESGLSVIQETRLYNPDNNTTQAMRGKENENDYRYFPDPDLLPIHIDKEQIEAIKNNLPDLPEAISKELKNTPSLNDEDINFILSSPDTYQYYKKIKSLCPAADKTIINWLKGQYAAFLNEHNLTFETPPISAKTMAAFLSKIHEKKISSSIAKNIFSMLCTGEKDIDAIIEREGYQQQNDNSALEEIVEQIIKQYPEQVTEYKAGKEKLLAFFIGQAMKQTKGKANPEQINLLLKKHLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: UN933_ARATH
Sequence: MESRNDEEAPLISASGEDRKVRAGKCYTRDVHILSISFLLIFLAYGAAQNLETTVNKDLGTISLGILYVSFMFCSMVASLVVRLMGSKNALVLGTTGYWLFVAANLKPSWFTMVPASLYLGFAASIIWVGQGTYLTSIARSHATDHGLHEGSVIGVFNGEFWAMFACHQLFGNLITLALLKDGKEGSTSGTTLLMLVFLFSMTLGTILMFFIRKIDGEDGKGPVGSPVGLVDSLASLPRMIITPLLDIRMLLIVPLLAYSGLQQAFVWAEFTKEIVTPAIGVSGVGGAMAVYGALDAVCSMTAGRFTSGLSSITFIVSGGAVAQASVFLWLLLGYRQTSGVLGTAYPLIMAAILGIGDGILNTQISALLALLFKHDTEGAFAQLKVWQSAAIAIVFFLSPYISLQAMLIVMLVMRDFTVEETHFTSSLLFQNSLSRNSLRFRRCLTIKIWDSLPISWESSFSYW
What are the official names of this protein?
UNC93-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the unc-93 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EVGA_SHIFL
Sequence: MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG
What is the function of this protein?
Member of the two-component regulatory system EvgS/EvgA.  Regulates the expression of emrKY operon and yfdX.  Seems also to control expression of at least one other multidrug efflux operon (By similarity).
What are the official names of this protein?
DNA-binding transcriptional activator EvgA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_NEIG2
Sequence: MDLHNIREDYSKRELSEADCADNPIEQFERWLDEAVRAEVNEPTAVNVAAVDGRGRPNSRMVLLKEVNSEGFVFFTNYHSRKGRSLELNPFAAMTFFWPELERQVRVEGRVGRLAEKLSDEYFESRPYQSRLGAWASAQSEVIPNKAVLVAKAAAVGLKHPLHVPRPPHWGGYIVIPDLIEFWQGRPSRLHDRIQYRLLDGGWIRERLSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RLMC_ECO7I
Sequence: MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSDTKLAQLRKALPWLQEQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPIKHMWDLFCGVGGFGLHCATPDMQLTGIEIAPEAIACAKQSAAELGLTRLQFQALDSTQFASAQGEVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLLVKQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: RLME_ALBFT
Sequence: MKSQTKSSKVNRAWLNDHVNDTYVKLAKLEGYRARAAYKLKEIDETLGLIKPGQLVVDLGSTPGAWSQYVRRKMSPKTATGGGAAVGALNGTIIALDILPMEPVEGVVFLQGDFRESDVLLQLEAEMKGRQADLVLSDMAPNLSGIDSADAARIENLVELALEFAQNHMKPEGALVAKVFHGASYDPLVKRFKETFLLVKRIKPKASRDKSSETFLVGLGLKPH
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MO4L2_MOUSE
Sequence: MSSRKQASQTRGQQSAEEDNFKKPTRSNMQRSKMRGAASGKKSAGSQPKNLDPALPGRWGGRSAENPPSGSVRKTRKNKQKAPGNGDGGSTSEVPQPPRKKRARADPTVESEEAFKSRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVGGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQIYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVASADYHRKAL
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400.  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.  Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
What are the official names of this protein?
Mortality factor 4-like protein 2, MORF-related gene X protein, Sid 393, Transcription factor-like protein MRGX.
What are the subcellular locations of this protein?
Nucleus.
Protein: RELB_CHICK
Sequence: MFAPSLAAFRAMALPIPRLAPVMKSVQPASFPVLGSMAARLSTARGGRGLRAGRRPPGGPKGAAAAEEMAVPIGAALQDPNVGMAPVNDDLEIIEEVMKEDGFQPDPPPPGSPHDPPKLIPRGLGVPVGRRDPPRDPPRLIITEQPKKTGMRFRYECEGRSAGSILGESSTEASKTLPAIELLNCQAIPEVQVTACLVWKDWPHRVHPHGLVGKDCSNGLCQVRLQPHANPRHSFSNLGIQCVKKKEIEAAIEKKLQLGIDPFKAGSLKNHQEVDMNVVRICFQASYRDGSGRTRQLSPVLSEPIFDKKSTNTSELRICRMNKESGPCTGGEELYLLCDKVQKEDIAVVFRKEPWEARADFSQADVHRQGAIVLRTPPYRCVQLSEPVQVEVFLQRLTDRARSRGCPYTYLPRERDAYGVKVKRKRGMPDLLEELSGADPYGIEAKRRKPPPGFMDHFAPLPAADEAFALLADPLDPLSHLPPPSTPQILWGRSYFRTPPPTETPTPPTASWGPICSQGTSEGGGGRTSPRYRPPPPLKWGSQWAPPHQ
What is the function of this protein?
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.  NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.  The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.  Different dimer combinations act as transcriptional activators or repressors, respectively.  NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.  NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.  In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus.  NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators.  Stimulates promoter activity in the presence of p49- and p50-NF-kappa-B.  Neither associates with DNA nor with p65-NF-kappa-B.  May play a role in the regulation of the circadian clock (By similarity).
What are the official names of this protein?
Transcription factor RelB homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: EX7L_STRPQ
Sequence: MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_HAEIE
Sequence: MNNVLVLKSSISGNNSQTNQLADYVIEKLQGNHIVVRDLAQQPLPYFDTVAAIAVRGEPKTTEEKQLLALSDELIEELKNAQTLIIGAPMYNLNIPTQLKSYFDFIARPRVTFQYTAKGPEGLLKGKKAIVLCAFGGLYDEENLVTQYMKSILGFIGITDVQFVYAQGIGLGAEAIEKAQSSAKNKINELITSL
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: Y3512_METJA
Sequence: MRILLLEGITDVAFFIPILKKLYGFSEISCDGIIRAEKMGDISKPICLENEDVKLIVFHSGGKSKQKHALTAMLTAIKMGYLSNIKILGIARDIDQEHDVKNWTKSIIKNAGFEVKEGDKFLIIEDLNLKIAVLGIANYDEDDFNIPSFELKRELEAVITDMAKEISIIEKFKNSLESLSNDAERRLKPKDITHVLAIAKNFDGDSMSGLYRKFIEEQINNKNKVNFLLTLICILPCLTIF
What are the official names of this protein?
Uncharacterized protein MJECL12.
Protein: USPA_SALTI
Sequence: MAYKHILIAVDLSPESKVLVEKAVSMARPYNAKISLIHVDVNYSDLYTGLIDVNLGDMQKRISKETHHALTELSTNAGYPITETLSGSGDLGQVLVDAIKKYDMDLVVCGHHQDFWSKLMSSARQLINTVHVDMLIVPLRDEEE
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein A.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.