PharMolix/UniProtQA huggingface dataset:
Protein: XPT2_CLOBH
Sequence: MKLLEDKILKEGILLEGNILKVDSFLNHQMDVKLFNEIGKEFKRRFEGCSINKILTIEASGIGIATIVSQYFDFCPVVFAKKVDAANMDKDTYESKVHSFTKNKTYNVRVSKKYINKGDKILLIDDFLANGCAALGLIDIIKQGGAELIGVGIAIEKGFQKGRKELEKVGAKVESLAILDKIENDKVYFK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase 2, XPRTase 2.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_KLEP3
Sequence: MVTIRLARHGAKKRPFYQVVVTDSRNARNGRFIERVGFFNPIASGAEEETRLDLDRIAHWVGLGATVSDRVAALIKAANKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: MIAA_SHIF8
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GALR3_RAT
Sequence: MADIQNISLDSPGSVGAVAVPVIFALIFLLGMVGNGLVLAVLLQPGPSAWQEPRSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSLDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGRRRHRHHHRAHRALRRVQPASSGPAGYPGDARPRGWSMEPRGDALRGGGETRLTLSPRGPQ
What is the function of this protein?
Receptor for the hormone galanin and spexin-1.
What are the official names of this protein?
Galanin receptor type 3, GAL3-R, GALR-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECR_CERS4
Sequence: MAEAPGDIERLIELMARLPGLGPRSARRAVLLMLKKRGAVMAPLAQAMAEVATSARDCVRCGNITNADLCGICRDERRATGELCVVEDVADLWALERAGAFRGRYHVLGGVLSALDSVGPEELRIPRLAERVREEGISEVILALNATVDGQTTAHYIADVLEPSGVQVTSLAQGVPIGGELDYLDDGTIGAALRARRRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: VATA_METJA
Sequence: MPVVGKIIKIAGPVVVAEGMKGAQMYEVVKVGEEKLTGEIIQLHDDKAVIQVYEETSGIKPGEPVVGTGAPLSVELGPGMLRAMYDGIQRPLTAIEEKTGSIFIPRGVDVPALPRDIKWEFKPVVNEGDYVEEGDIIGTVDETPSIVHKILVPIGVKGKIVEIKEGKFTVEETVAVVETENGERKEITMMQKWPVRKPRPYKEKLPPEIPLITGQRVEDTFFTLAKGGTAAIPGPFGSGKTVTQHQLAKWSDADVVVYIGCGERGNEMTEVIEEFPHLEDIRTGNKLMDRTVLIANTSNMPVAAREASVYTGITIAEYFRDMGYGVLLTADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVITLGKDNRQGFVCIVGAVSPPGGDFSEPVTSNTLRIVKVFWALDANLARRRHFPAINWLQSYSLYIDDVTEWWNTNTGPDWRQLRDEAMSLLQKEAELQEIVQLVGPDALPDRERVILEVARMLREDFLQQDAFDEVDTYCPPMKQYLMLKIIMTFYQEALKAVERGVEPAKILGVSVKQDIARMKYIPHDEFINVKSKEIMEKIKNELGSLN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit (By similarity).
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: P121A_HUMAN
Sequence: MSPAAAAAGAGERRRPIASVRDGRGRGCGGPARAVLLGLSLVGLLLYLVPAAAALAWLTVGATAAWWGLSREPRGSRPLSSFVRKARHRRPLSSFVRKARHRRTLFASPLAKSTANGNLLEPRTLLEGPDPAELLLMGSYLGKPGPPQPAAAPEGQDLRDRPGRRPPARPAPRSPPPRSPPPRSPPPSPPTHRAHHVYPSLPTPLLRPSRRPSPRDCGTLPNRFVITPRRRYPIHQAQYSCLGVLPTVCWNGYHKKAVLSPRNSRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKEKKRTVEEEDQIFLDGQENKRRRHDSSGSGHSAFEPLVANGVPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYASGIPSSSRNAITSSYSSTRGISQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADRESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSAPPMFKPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLHTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALAPSFGSSFTFGNSAAPAAAPTPAPPSMIKVVPAYVPTPIHPIFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSTTTGAFSFGAGQSGSTATSTPFAGGLGQNALGTTGQSTPFAFNVSSTTESKPVFGGTATPTFGLNTPAPGVGTSGSSLSFGASSAPAQGFVGVAPFGSAALSFSIGAGSKTPGARQRLQARRQHTRKK
What is the function of this protein?
Essential component of the nuclear pore complex (NPC).  The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.  When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).
What are the official names of this protein?
Nuclear envelope pore membrane protein POM 121, Nuclear envelope pore membrane protein POM 121A, Nucleoporin Nup121, Pore membrane protein of 121 kDa.
What is the protein family that this protein belongs to?
Belongs to the POM121 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.
Protein: STHA_AZOVD
Sequence: MAVYNYDVVVIGTGPAGEGAAMNAVKAGRKVAVVDDRPQVGGNCTHLGTIPSKALRHSVRQIMQYNNNPLFRQIGEPRWFSFADVLKSAEQVIAKQVSSRTGYYARNRIDTFFGTASFCDEHTIEVVHLNGMVETLVAKQFVIATGSRPYRPADVDFTHPRIYDSDTILSLGHTPRRLIIYGAGVIGCEYASIFSGLGVLVDLIDNRDQLLSFLDDEISDSLSYHLRNNNVLIRHNEEYERVEGLDNGVILHLKSGKKIKADAFLWSNGRTGNTDKLGLENIGLKANGRGQIQVDEHYRTEVSNIYAAGDVIGWPSLASAAYDQGRSAAGSITENDSWRFVDDVPTGIYTIPEISSVGKTERELTQAKVPYEVGKAFFKGMARAQIAVEKAGMLKILFHRETLEILGVHCFGYQASEIVHIGQAIMNQKGEANTLKYFINTTFNYPTMAEAYRVAAYDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP1G2_ARATH
Sequence: MNPFSSGTRLSDMIRAIRASKTAAEERAVVRKECAAIRASINENDQDYRHRDLAKLMFIHMLGYPTHFGQMECLKLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSLKQDLNHTNQYIVGLALCALGNICSAEMARDLAPEVERLLQFRDPNIRKKAALCAIRIIRKVPDLSENFINPGAALLKEKHHGVLITGVHLCTEICKVSSEALEYFRKKCTEGLVKTLRDIANSPYSPEYDVAGITDPFLHIRLLKLLRVLGQGDADASDCMNDILAQVASKTESNKNAGNAILYECVQTIMSIEENGGLRVLAINILGKFLSNRDNNIRYVALNMLMRSLTVDSQAVQRHRATILECVKDSDASIQKRALELIYLLVNENNVKPLAKELIEYLEVSEQDFKGDLTAKICSIVEKFAPEKIWYIDQMLKVLSEAGTYVKEDVWHALIVVITNAPDLHGYTVRALYRALHTSFEQETLVRVAIWCIGEYADLLVNNAGMLDLEDPITVTESDAVDVVENAIKHHLSDVTTKAMALIALLKISSRFPSCSERVKSIIGQNKGSFVLELQQRSLEFSSVIQKHQNIRSSLVERMPVLDEATFSGRRAGSLPASVSTSGKSPLGIPNGVAKAAAPLVDLLDLGSDDTPAPTSSSNNFLQDLLGVDLSQPSAQPGAMQPSQAGADILMDLLSIGTPAPVQNGSANGDLLSIQDNNAPIAPSLTSPTAPSSMMDLLDGFGPTPPKSEDKSAAYPSIVAFESSSLKIEFNFTKQSENPQTTDIVANFINLTPNVYTEFLFQAAVPKFLQLHLDPASSNSLPANGNIKQTMRVTNSQKGKKPIVMRMRVGYKINGKDVLEEGQINNFPRGL
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE).  The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
What are the official names of this protein?
AP-1 complex subunit gamma-2, Adaptor protein complex AP-1 large subunit gamma-2, Adaptor-related protein complex 1 subunit gamma-2, Clathrin assembly protein complex 1 gamma-2 large chain, Gamma-adaptin 2.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARLY_SALHS
Sequence: MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTADEQRQLEEALNVLLEEVRANPQQILQSDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKETVRELLTANRQLQSALVETAQANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDTLKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSDAAIGMVHLSRFAEDLIFFNSGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQDAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKPLEALPLADLQKFSHVIGDDVYPMLSLQSCLDKRAAKGGVSPQQVAQAINDAKARLAL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YICR_SHIDS
Sequence: MKNNAQLLMPREKMLKFGISALTDVELLALFLRTGTRGKDVLTLAKEMLENFGSLYGLLTSEYEQFSGVHGIGVAKFAQLKGIAELARRYYNVRMREESPLLSPEMTREFLQSQLTGEEREIFMVIFLDSQHRVITHSRIFSGTLNHVEVHPREIIREAIKINASALILAHNHPSGCAEPSKADKLITERIIKSCQFMDLRVLDHIVIGRGEYVSFAERGWI
What are the official names of this protein?
UPF0758 protein YicR.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: FLZ7_ARATH
Sequence: MLLGNRPRPQMQRTASITRITIEVDGDQTAGQDSDVSMTVVDGGENYAQRFLSPVNHQRNERKYGGRSSPSSFLVNCGFCKRGLAPGRDIYMYKGDAAFCSIECREQQMEHDEGKTRNRVVLSPSK
What is the function of this protein?
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
What are the official names of this protein?
FCS-Like Zinc finger 7.
What is the protein family that this protein belongs to?
Belongs to the FLZ family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NRDR_CAUVN
Sequence: MRCPFCGHAESQVKDSRPSEDGAAIRRRRMCPECGGRFTTFERVQLRELIIVKRSGRRSPFDRDKLVRSVGLATQKRPVDPERVERMVNGIVRQLESMGETELPSSTVGEMVMKALKSLDDVAYVRYASVYRDFKETSDFAKFLTEEGLSDGGEEEL
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RS6E_PYRHO
Sequence: MTTFKLVISDPKSGIAKQIEISGANAEKLIGKKIGDQIPVKELGLDLKALFGKDFPEDVKMEIRGGTDKDGFPMRPDIHGPRRVRILLSKGPGFRPKEKGERRKKTVRGNTISPEIVQVNVKLVY
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: SYB_DROME
Sequence: MENNEAPSPSGSNNNDFPILPPPPNANDNYNQFGDHQIRNNNAAQKKLQQTQAKVDEVVGIMRVNVEKVLERDQKLSELGERADQLEQGASQFEQQAGKLKRKQWWANMKMMIILGVIAVVLLIIVLVSVWPSSSDSGSGGGNKAITQAPPH
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
What are the official names of this protein?
Synaptobrevin.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Note=Neuronal synaptic vesicles (By similarity). In embryos, expressed in the plasma membrane of tracheal cells (PubMed:27323327).
Protein: NRDR_CROS8
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEDKLRSGMQKALEKRPVSSDDVEMAINHIKSHLRATGEREVPSKLIGNLVMEQLKKLDKVAYIRFASVYRSFEDIREFGEEIARLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TRPD_RHOP5
Sequence: MIDFKSIIGKVATGATLTRDEATAAFDAMMSGEATPSQMGALLMGLRVRGETVDEIAGAVSAMRAKMLTVTAPPDAVDVVGTGGDGSGSVNVSTCAAFIVAGCGAPVAKHGNRALSSRSGAADVLAALGVKIDITPDQVGRCIAEAGIGFMFAPTHHPAMKNVGPTRVELATRTIFNMLGPLSNPAGVKRQMVGVFSRQWVQPLAQVLKNLGSEAVWVVHGSDGLDEITISGPTFVAALKDGEITTFEITPEDAGLPRAPAESLKGGDAEANAAALKGVLQGKPSPYRDVALLNAGATLIVAGRAGDLKEAVALGAQSIDSGAAAARLAKLIAVSNTAE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL24_FRATH
Sequence: MNRLKKGDDVIVIAGKDKGRRGVVKSFAKGGSLVLVEGINIVKKHIKPNPNRGIEGGVVEKELPVDASNVAIFNPATEKADRVGYKFVDEKKVRYFKSNGELVDL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RS14_PSEAB
Sequence: MAKESMKNRELKRQLTVAKYAKKRAELKAIIANPNSSAEERWNAQVALQKQPRDASASRLRNRCRLTGRPHGFYRKFGLSRNKLREAAMRGDVPGLVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: A4A1_LOXIN
Sequence: MLFPTALIFGCWALVIEGADNRRPIWNMGHMVNEVYQIDEFVDLGANSIETDITFDDDAMAEYSYHGVPCDCRRWCHKWEYVNVFLDGLRRATTPGDSKYRPELTLVVFDLKTGDLSSSTAYKGGKLFAQKLLDRYWNGGNNGGRAYIIISIPDIDHYAFITGFREALKNANHEELLDKVGYDFSGNDDLSSTRTALNKAGVKDREHVWQSDGITNCILRGLDRVREAVRNRDSSNGYINKVYYWTIEKYVSVRDALDAGVDGIMTNEPDVIVNVLNEGNYRGRFRLANYDDNPWVTFK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) with high activity (PubMed:23733617).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Has hemolytic activity in human erythrocytes in a dose-dependent manner (PubMed:23733617).  In vivo, this toxin induces dermonecrosis, edema, hemorrhage, massive inflammatory response, as well as vascular permeability (PubMed:23733617).  In addition, thrombus formation has also been detected in dermal blood vessels (PubMed:23733617).  It also induces platelet aggregation (By similarity).  It is noteworthy that a Glu-248 replaces the Asp present in paralogs, without decrease in catalytic and hemolytic activities (PubMed:23733617).
What are the official names of this protein?
Dermonecrotic toxin LiSicTox-alphaIVA1, Dermonecrotic toxin 7, DT7, LiRecDT7, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D 7, SMD 7, SMase D 7, Sphingomyelinase D 7.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily. Class IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UVRB_HAMD5
Sequence: MRKAFKLHSNFKPSGDQPEAIHQLKEGLKNGLMHQTLLGVTGSGKTFTVANVIADLNRPTMILAPNKTLAAQLYGEMKDFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIEQMRLSATKALLERQDVIVVASVSAIYGLGDPDLYLKMMLHLTKGMIIDQRAILARLSELQYSRNDQVFQRGTFRVRGENIDIFPAESSDFAVRIELFDDEVERLSLFAPLTGHIQKTVPRFTVYPKTHYVTPRARILQSMEEIKIELAQRREQLLANNKLVEEQRLTQRTQFDLEMMNELGYCSGIENYSRYLSGRAAGEPPPTLFDYLPSEGLLVIDESHVTIPQIGGMYKGDRSRKQTLVEYGFRLPSALDNRPMRFEEFESLAPQTIYISATPGPYELGKSAGELIEQVVRPTGLLDPVIEVRPVATQVDDLLSEIRQRVVIDERVLVTTLTKRMAEDLTEYLAEQGERVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDKITVSMKKAIDETERRRKKQESYNKEKGIVPKKLEKKIRDILELGQSYTKGKARKRTTTLEENSTNYTALSPKAIKKKIDELEQKMHDHAQNMEFEKAGQLRDEIQQLTLLLNAPQ
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTPB_XENBS
Sequence: MSKTASVGLWDQPKPFFMIFFVELWERFGFYGVQGILAIYFVQQLGFSEEQSFITFGAFTALVYGLISVGGYVGDHILGTKRTIVLGAIVMAIGYYMIGLSIMKPELIFYALGTVAVGNGLFKANPASLLAKCYQPQDPRLDGAFTLFYMSINLGSLFSLSLAPVIAEKYGYTVTYNICGIGLIIALLVYIACRRMVHNIGSAPDHHPVKPIGLIAVLIGSVVMVGVCAWLLHNIKVANIALFAITTIVVLIFFWQAFKQNRVGRNKMFVAFILMLQAVVFFILYNQMPMSLNFFAINNVHHQILGFDVNPVSFQAFNPFWIIIVSPILAVVYTKLGAKGKDFSMPAKFTFGMFLCSLGFLTAAASGLFADAQGITSPWFIVLVYLFQSVGELMISALGLAMVAAFVPSYLTGFILGMWFLSQAVASMLASHVAALTATPVGVTDPLQTLPIYMSVFGKIGVATLIVAIIMTFMVPWLNRIMREEVKA
What is the function of this protein?
Proton-dependent permease that transports di- and tripeptides.
What are the official names of this protein?
Dipeptide and tripeptide permease B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SRY_MELME
Sequence: MVWSRDQRRKVALENPQMQNSEISKQLGCQWKMLTEAEKRPFFEEAQRLQAMHRE
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: OSBP2_MOUSE
Sequence: MGKAAALSRGGGCAGRSRGLSSLFTVVPCLSCHTAAPGMNSSAFGSGPASKPQLQPVQAPERELLSKQVCQPISEPASRSEPGSQTTSVPRPSGVGQESELQGLWPGSENGTRSVSIIKASPELAMPSPLQSTVGSLPVTKPESKLVPKTQSFLRQGQAKISVGTPVSGIGVQMVSPPLDSYKGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRATINLASTHFETEDSCGILLCNGARTYHLKASSEVDRQHWITALELAKAKAIRVMKTQSDDSGDDDEEPAAPADNSELHHTLKTLSLKLNDLSTCNDLIAKHGAALQRSLNELDSLKIPSECGEKLKVVNERATLFRITSNAMINACRDFLELAETHSRKWQRALNYEQEQRVHLEETIEQLAKQHNSLERAFCNTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTSFITVVTEAKEDRKPESGPGTTTVDWTSADNVLDGASFMPKNSCKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRMEDMGLRSLCEQVSHHPPSAAHHVFSKHGWSLWQEITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTKDRCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDDQMECSKIVHSSPSSDGRQKTVYQTLPAKLLWRKYPLPENAENMYYFSELALTLNEQEDGVAPTDSRLRPDQRLMERGRWDEANTEKQRLEEKQRLSRRRRLESCTAGCGGEEEKESDGYVPLWFEKRLDPLTGEMACMYKGGYWEAKEKKDWHMCPNIF
What is the function of this protein?
Binds 7-ketocholesterol.
What are the official names of this protein?
Oxysterol-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: LSRF_SALTI
Sequence: MADLDDIKDGKDFHTDKPQTNTLFSLKGCGALDWGMQSRLARIFNPRTRKTVMLAFDHGYFQGPTTGLERIDINIAPLFEYADVLMCTRGILRSVVPPAINKPVVLRASGANSILTELSNEAVAVAMDDAVRLNSCAAAAQVYIGSEHEHQSIKNIIQLIDAGLRVGMPIMAVTGVGKDMARDQRYFSLATRIAAEMGAQIIKTYYVDKGFERIAAGCPVPIVIAGGKKLPEREALEMCYQAIDQGASGVDMGRNIFQSEDPVAMIKAVHAVVHHNETAERAYELFLSEKG
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_HELAH
Sequence: MQEIENLHKSVLLQEVLQAFAPLEKGVFIDCTLGLGGHSKALLSQKPHLKLIGIDKDKHAQEIAKERLKAFEGCYHILSGGFAKRFKEALETHGEQIKGVLVDLGVSSLQLDDDNRGFNFHSHALDMRMDLESELNAQKVINSYCIVALEKIFKDYGAIKEYKKIAHHIVERRAKKPFKDAKDLSDFLSSLSKNKKIHPATLVFQAIRIEVNRELEELKEFLQDAMKLKGAILCVISFHSLEDALVKNAFKNYAKNCICDALNFKCTCSNNHALGEILTKKPITPSLEEIKHNRRSRSAKMRVFQFKP
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.