PharMolix/UniProtQA huggingface dataset:
Protein: KPRS_MARMM
Sequence: MKLMSGTANPDLSRSIADYLDAPLTASHIERFADGEIFVRIDENVRGEDVFILQSTSRPANDHLMELLICIDALVRASARRITAVIPYFGYARQDRKTGGRTPISAKLVANLIAKAGADRVLTVDLHAGQIQGFFDIPTDNLFATKVMEADIRRHYETDNLLIVSPDVGGVVRARALAKLLDAEIAIVDKRRPKAGVAEVMNIIGEVEGRRCILFDDMCDSGGTLVNAADALLEKGAIEVSAYVTHGVLSKDAQGRVDKSRLRELVVTDSVTEPPNSTATPKVRRLSVAPLLGEAIRRIANDESVSKLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_STRSY
Sequence: MKLQKPKGTQDLLPQDSAKWQYVENFTRSIFKQYNYAEIRTPIFEHYEVISRSVGDTTDIVTKEMYDFYDKGERHITLRPEGTAPVVRSYVENKLFAPEVQKPAKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSNNPATDVETIAMAYHFFEELGIKDIRLHLNSLGNPESRAAYRQALIDYLTPLKEQLSKDSQRRLEENPLRVLDSKEKEDKVAVENAPSILDYLDEESTVHFEAVRSMLDNLGITYTIDTNMVRGLDYYNHTIFEFMTEVGGNDLTICAGGRYDGLVTYFGGPETPAFGFGMGIERLILVLEKQGIELPLDTQLDVYIAVLGQEANGGALDLVQAIRKQGFRAERDYLDRKLKAQFKSADVFGAKAIITLGGSEIESGQVVVKNNQTRSQVETSLEALKTDFASILEELEKQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM13_MOUSE
Sequence: MWHNVGLTLLVFVATLLIVLLLMVCGWYFVWHLFLSKFKFLRELVGDTGSQEGDNEQPSGSETEEDPSASPQKIRSARQRRPPVDAGH
What are the official names of this protein?
Small integral membrane protein 13.
What is the protein family that this protein belongs to?
Belongs to the SMIM13 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PUR5_BURMS
Sequence: MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLALMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADDALRQLADAGEQVWKIGTVRASREGEAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSG1_CANLF
Sequence: MNWHFLRTATVLLIFLVVVEINSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREITPFFIIYCRALNSLGQDLERPLELRVRVLDINDNPPVFSMSTFVGQIEENSNANTLVMRLNATGADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYSQYSLAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEPSSHMVRIEENALSQNLVEIRVIDLDEEFSANWMAVIFFISGNEGGWFDIEMNERTNVGILKVIKPLDYEAVQNLQLSLGVRNKADFHHSIMSQYKVTATAISVTVLNVIEGSVFRPGSKTYVVRSDMGQNYKVGDFVATDLDTGLASTTVRYVMGNNPANLLNVDSKTGVITLRNKVTMEQYEMLNGKYQGTILSIDDALQRTCTGTINIDLQGSGWEKDSEKVTSSQNSGSSTGDSSGGTGGGGRENPSEGDTTTNTGGKTSTDYEDGETQTQSNNNHQELGSNNLSDNVHFGPAGIGLLIMGFLVLGLVPFLLMCCDCGGAPGAGAGFEPVPECSDGAIHSWAVEGPQPLPTDATTVCVPPIPSNNANVIECIDTSGVYTNEYGGREMQDLGGGERTTGFELTEGVKTSGVPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKEVEPDPSWPPESTEPICPQQGTEPIIGGHPPISPHFGTTTVISENTYPSGPGVQHPMPIPDPLGYGNVTVTESYTTSGTLKPTVHVHDNRHASNVVVTERVVGPISGTDLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTMPDPRESSNVVVTERVIRPASGMMGNLSIHPELSNAQNVIVTERVVSGSGISGISGLVGSAMGVSGGGMAMNSLGGGGGLSSSMGGTATIGHVRSSSDHHFSQTLGSASPSTARSRITKYSTVQYTK
What is the function of this protein?
Component of intercellular desmosome junctions.  Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
What are the official names of this protein?
Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Protein: PDCD5_PONAB
Sequence: MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY
What is the function of this protein?
May function in the process of apoptosis.
What are the official names of this protein?
Programmed cell death protein 5.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: VAPC8_MYCTO
Sequence: MTEGEVGVGLLDTSVFIARESGGAIADLPERVALSVMTIGELQLGLLNAGDSATRSRRADTLALARTADQIPVSEAVMISLARLVADCRAAGVRRSVKLTDALIAATAEIKV
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  The cognate antitoxin is VapB8 (By similarity).
What are the official names of this protein?
Ribonuclease VapC8, RNase VapC8, Toxin VapC8.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: MTTB_METBA
Sequence: MAKNNAVAGFNALNGVELNLFTTDELKAIHYATMEVLMDPGIQVSDPEARQIFKENGCEVNEKTNVVKIPEYLVRKALQLAPSRFVLWGRDKKFNTVQECGGKVHWTCFGTGVKVCKYQDGKYVTVDSVEKDIADIAKLCDWAENIDYFSLPVSARDIAGQGAQDVHETLTPLANTAKHFHHIDPVGENVEYYRDIVKAYYGGDEEEARKKPIFSMLLCPTSPLELSVNACQVIIKGARFGIPVNVLSMAMSGGSSPVYLAGTLVTHNAEVLSGIVLAQLTVPGAKVWYGSSTTTFDLKKGTAPVGSPELGLISAAVAKLAQFYGLPSYVAGSOSDAKVPDDQAGHEKTMTTLLPALAGANTIYGAGMLELGMTFSMEQLVIDNDIFSMVKKAMQGIPVSEETLAVESIQKVGIGNNFLALKQTRQLVDYPSNPMLLDRHMFGDWAAAGSKDLATVAHEKVEDVLKNHQVTPIDADIFKDMQAIVDKADKAFRGM
What is the function of this protein?
Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
What are the official names of this protein?
Trimethylamine methyltransferase MttB, TMA methyltransferase, Trimethylamine--corrinoid protein methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the trimethylamine methyltransferase family.
Protein: NIKR_BRUO2
Sequence: MQRITITIDDDLMAALDRMIEIKGYQNRSEALRDLARTGLQQASLEEGQMEACVGVLSYTYDHSARDLSKKLTNTHHDHHNISVASMHVHLDHDRCLEVSILKGKTDDVRHFADHVKAERHVTHGTLAVLPL
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: SECB2_FRATW
Sequence: MDQQAQPQFQIQKVYVKDLSFSIPNSDKIWTTNWKPELHTDLKVEATKLPEENTYETVLTLEVKVENDGMVAFEAEVKQAGIFTVANMQEAQIEHAKKAFCPNILYHYAREAISDLVISGGFPQLCLSAVNFDAMYQDSLKESADSKQH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB 2.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOJ_RICTY
Sequence: MPIFFYLFTTLIIISSLCVVLSKNSVYSVLWLIFTFINAAGLMILLGAEFLAMLLIVIYVGAVAVLFLFVIMMLDINFNQAITKLRENLSLSIFITLIMFVDLVITVILSTKNINHSSNISFAIANNISNTKAIGSVLYTDFMLPFQMAGLILFVAMISCITLTLKKRERVKYQDIRKQLSHNKGNVILMTKPILNKGVENIKYE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit J, NADH dehydrogenase I subunit J, NDH-1 subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DF192_ARATH
Sequence: MATKSVSTFAIFFILVLAIFETPEIEAYDRKCLKEYGGDVGFSYCAPRIFPTFCDQNCRKNKGAKGGVCRWEENNAIGVKCLCNFCSEEPSDQTLSRI
What are the official names of this protein?
Defensin-like protein 192, Trypsin inhibitor ATTI-7.
What is the protein family that this protein belongs to?
Belongs to the DEFL family. Protease inhibitor I18 (RTI/MTI-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGJ_CORCT
Sequence: MAEKGITAPKGFVASATTAGIKASGNPDMALVVNQGPEFSAAAVFTRNRVFAAPVKVSRENVADGQIRAVLYNAGNANACNGLQGEKDARESVSHLAQNLGLEDSDIGVCSTGLIGELLPMDKLNAGIDQLTAEGALGDNGAAAAKAIMTTDTVDKETVVFADGWTVGGMGKGVGMMAPSLATMLVCLTTDASVTQEMAQIALANATAVTFDTLDIDGSTSTNDTVFLLASGASGITPTQDELNDAVYAACSDIAAKLQADAEGVTKRVAVTVVGTTNNEQAINAARTVARDNLFKCAMFGSDPNWGRVLAAVGMADADMEPEKISVFFNDKAVCLDSTGAPGAREVDLSGADIDVRIDLGTSGEGQATVRTTDLSFSYVEINSAYST
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SED2_ASPFU
Sequence: MFSSLLNRGALLAVVSLLSSSVAAEVFEKLSAVPQGWKYSHTPSDRDPIRLQIALKQHDVEGFETALLEMSDPYHPNYGKHFQTHEEMKRMLLPTQEAVESVRGWLESAGISDIEEDADWIKFRTTVGVANDLLDADFKWYVNEVGHVERLRTLAYSLPQSVASHVNMVQPTTRFGQIKPNRATMRGRPVQVDADILSAAVQAGDTSTCDQVITPQCLKDLYNIGDYKADPNGGSKVAFASFLEEYARYDDLAKFEEKLAPYAIGQNFSVIQYNGGLNDQNSASDSGEANLDLQYIVGVSSPIPVTEFSTGGRGLLIPDLSQPDPNDNSNEPYLEFLQNVLKMDQDKLPQVISTSYGEDEQTIPEKYARSVCNLYAQLGSRGVSVIFSSGDSGVGAACLTNDGTNRTHFPPQFPAACPWVTSVGGTTKTQPEEAVYFSSGGFSDLWERPSWQDSAVKRYLKKLGPRYKGLYNPKGRAFPDVAAQAENYAVFDKGVLHQFDGTSCSAPAFSAIVALLNDARLRAHKPVMGFLNPWLYSKASKGFNDIVKGGSKGCDGRNRFGGTPNGSPVVPYASWNATDGWDPATGLGTPDFGKLLSLAMRR
What is the function of this protein?
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
What are the official names of this protein?
Tripeptidyl-peptidase sed2, Sedolisin-B.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: LIPA_BACC0
Sequence: MTKQTEYKRKPEWLKIKLNTNENYTGLKKMMRSKNLHTVCEEAKCPNIHECWAVRKTATFMILGAVCTRACRFCAVKTGLPTELDLQEPERVADSVVQMGLKHVVITAVARDDLKDGGAAVFAETVRAVRRKNPFTSIEVLPSDMGGVEENLKMLMDAKPDILNHNIETVRRLSNRVRARAKYDRSLEFLRRAKEMQPDIPTKSSIMVGLGETREDLIEAMDDLRANNVDILTLGQYLQPSKKHLPVLKYYPPAEFAELKEIALSKGFSHCEAGPLVRSSYHADEQVRSAKEKTAEAK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_STAAC
Sequence: MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORM_PSEAE
Sequence: MSSPSLVELKAILRLAGPLIAAQLAYVAMVFTDTVMMGKLGPDALAAGGLGAVSYAFVSTFCVGVVAAVGNLVAIRHGCDDAAGAAAAARSGLWVGAALALAAGLLLWNLRPLLLVFGQAPQTVDGAMQFLHSLTFALPGYMAFMVLRGFTSAIDRAGPVMAISVLGALANLALNYSFIEGLFGLPRLGLAGIGLVTALVMNCMPLLLALYIRLQPAYAEYSLLRGLGRPQRAMVEEILRLGLPIGGTYAVESGMFTVATLCMGIIGDHALAAHQIAIQAVYVAFMVPVGLSYATTYRIGQHFGAGRLLEARRAGRVGIGFGALCMLLFAGLFWWMPEAIIGLFLDRDAPANREVAAMAVSLLAIAAWFELFDGTQNVAMGAIRGLKDARTTFLVGLACYWLVGVPLACLLAFAAGWGAAGVWWGLAGGLACAAIGLTLAFEWKTARLLPKATASEASALNCRAAGRGAPSARLCPGNAPVPPTAAAD
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL18_PARMW
Sequence: MSKLSRKQQTQKRHRRLRRHLTGTSDRPRLAVFRSNNHIYAQVIDDDAQSTLCSASTVDKELRAGLEANGGSCDASVAVGELVAKRAIAKGIQSVVFDRGGNLYHGRIKALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: LGT_SHESR
Sequence: MALNFPNIDPVIVKFGPFDIFGQTFEPALRWYGFTYLVGFVAAMWLLNRQADRSNGLWSREQVSDLLFYGFLGVILGGRIGYVLFYHFDYFLASPMYLFKISEGGMSFHGGLMGVITAMIYIAWKQKRTFFAVADMVAPVVPIGLGAGRIGNFINGELWGRVTDVPWAMVFPSGGPEPRHPSQLYQFALEGVALFLLLYWFSKRTKKVGAVSGMFLLGYGIFRVIVETVRQPDAQLGLYWGFMTMGQILSVPMVLFGLYLILRPEGKQ
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AAAS_ARATH
Sequence: MASFPHPGSVTVCEINRDLITAQNLSDERAQETYGKVLGMVFSPVSFDSTPSSLQENEGQENGDKASGESKGLVATLQMKVADSLKQILQPTDVTLLSEIDLQGVSWHQGKHIIAFISGANQVTIRDYEDKDEKEPCILTSDSQRNVKALEWRPNGGKSLSIACRGGICIWAASYPGNMALVRSGGSALRGSLSRGSGTRWILVDFLRCQNDEQISALSWSPCGRYLASASYDSSSFTIWDVSQGAGTPIRRGLGGISMLKWSPTGDYFFAARFDGTFCLWETNTWTSEPWSLSSGSGSVTGAIWDPEGRFILISFSKSSTLGSVHFSSKPPSLDAHLLPVELPEIASLTGCEGIEKIAWDASGERLAVSYKGGDENYKGLIAIYDTRRTPIVSASLVGFIRGPGENPKALSFSFHDKFKQGPLLSVCWSTGFCCTYPLIFRSHVLP
What are the official names of this protein?
Aladin.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus, nuclear pore complex.
Protein: TJB15_HUMAN
Sequence: SNQPQHFGDGTRLSIL
What is the function of this protein?
J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta joining 1-5.
What are the subcellular locations of this protein?
Cell membrane.
Protein: YMZC_BACSU
Sequence: MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYETPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE
What are the official names of this protein?
Uncharacterized protein YmzC.
Protein: RL27A_CANAL
Sequence: MAKFIKSGKVAIVVRGRYAGKKVVIVKPHDEGTKSHPFPHAIVAGIERAPLKVTKKMDAKKVTKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTSEALEEPSQREEAKKVVKKAFEEKHQAGKNKWFFQKLHF
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L27-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
Protein: DGK2_ARATH
Sequence: MMEVGFSLIQWLISSGADSPFIFGWLVTGSVGLLAVIYTFLKWQKKTSLNWVKAAAREKKKVWKRLRVPLSHHQWTDDYGYGQQPSTCCVCLYSLVPGQNVSNKASLSIPVHRCAVCGVAAHFYCSSSAAKDCKCVAQAGSDHVRHHWSERWVNMDDNADMTAFCFYCDEPCGIPFIEASPMWHCLWCQRLIHVKCHMIMSKESGDACDLGSLRRVILSPVHVKLNEANGVDGVLTTIKNELASIRGHVRRKRHRGKNGNGQSLNGKLLEDSVSDPVKTVVNGLVVKKLRRDRSIDCLKQVSDMPNAKGLQNGIGGHKRNKSAALNFMKKFSLVDLPPDARPLLVFINAKSGGQLGPFLHRRLNMLLNPVQVFELGSCQGPDAGLDLCSKVKYFRVLVCGGDGTVAWVLDAIEKRNFESPPPVAILPLGTGNDLSRVLQWGRGISVVDGQGSLRTFLQDIDHAAVTMLDRWSVKIVEESTEKFPAREGHKFMMNYLGIGCDAKVAYEFHMMRQEKPEKFCSQFVNKLRYAKEGARDIMDRACADLPWQVWLEVDGKDIEIPKDSEGLIVLNIGSYMGGVDLWQNDYEHDDNFSIQCMHDKTLEVVCVRGAWHLGKLQVGLSQARRLAQGKVIRIHVSSPFPVQIDGEPFIQQPGCLEITHHGQVFMLRRASDEPRGHAAAIMNEVLLDAECKGVINASQKKVLLQQMALHLS
What is the function of this protein?
Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule (PubMed:14665624).  PA is required for plant development and responses to abiotic stress and pathogen attack (Probable).  May be involved in the accumulation of PA during cold stress (Probable).  Involved in response to freezing stress by modulating the accumulation of PA (PubMed:29853600).  Exhibits high specificity for the unsaturated DAG analogs 1-stearoyl-2-arachidonoyl-sn-glycerol (1,2-SAG) and 1,2-dioleoyl-sn-glycerol (1,2-DOG) (PubMed:14665624, PubMed:16081412).  Exhibits high specificity for 1-palmitoyl, 2-oleoyl-sn-glycerol (1,2 POG), 1-stearoyl, 2-linoleoyl-sn-glycerol (1,2-SLG) and 1-oleoyl, 2-palmitoyl-sn-glycerol (1,2-OPG) (PubMed:16081412).  Has almost no activity toward 1,2-dioctanoyl-sn-glycerol (1,2-DOCG), 1,2-dipalmitoyl-sn-glycerol (1,2-DPG), 1,2-dimyristoyl-sn-glycerol (1,2-DMG) and 1-oleoyl-2-acetyl-sn-glycerol (1,2-OAG) (PubMed:16081412).  Functions together with DGK4 in male gametophyte development and biosynthesis of phosphatidylglycerol and phosphatidylinositol in the endoplasmic reticulum (ER) (PubMed:32471859).  Involved in PA production for pollen grain growth, as well as leaf and root growth (PubMed:32471859).
What are the official names of this protein?
Diacylglycerol kinase 2, AtDGK2, DAG kinase 2, Diglyceride kinase 2, DGK 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: CFA20_DROME
Sequence: MFKNTFQSGFLSILYSIGSKPLQLWDKKVRNGHIKRITDNDIQSLVLEIVGTNVSTTFITCPADPKKTLGIKLPFLVMIIKNMKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDEGWNQIQFNLSDFTRRAYGTNYVETLRVQIHANCRIRRVYFSDRLYSEDELPPEFKLFLPIQKPVQKSNAICS
What is the function of this protein?
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility.  Involved in the regulation of the size and morphology of cilia.  Required for sperm individualization, differentiation of the sperm flagellum and tubulin polyglycylation of axonemal microtubules.
What are the official names of this protein?
Cilia- and flagella-associated protein 20, Basal body up-regulated protein 22.
What is the protein family that this protein belongs to?
Belongs to the CFAP20 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium, flagellum. Note=Localizes in cilia of chordotonal organs in sensory neurons of the antenna. Localizes in small primary cilium composed of a transition zone and a short axoneme. Localizes at the top of the giant centrioles and enriched in the nucleolus of spermatocytes.
Protein: FCF1_MOUSE
Sequence: MGKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKFRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYLSNHRYNIERMPDDYGAPRF
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
rRNA-processing protein FCF1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UTP23/FCF1 family. FCF1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.