PharMolix/UniProtQA huggingface dataset:
Protein: PLLP_RAT
Sequence: MAEFPSKVSTRTSSPAQGVGASVSAMRPDLGFVRSALGVLALLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVFFIIYLFQLHMKLYMVPWPLVLLVFFVAATVLYITAFVACAAAVDLTSLRGSRPYNQRSAASFFACLVMIAYGLSAFFSFQAWRGVGSNAATSQMAGGYS
What is the function of this protein?
Appears to be involved in myelination.  Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective.
What are the official names of this protein?
Plasmolipin, Plasma membrane proteolipid.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZG17_XENLA
Sequence: TGEKSISCSECGKCFIKSSELTVHQMTHIGEKTYSCSECGKCFASLSHLRVHQKIHTGEKPFSCSECGKCFLNRGSLVRHHRTHTGEKPFFCSECGKRFAASSDLRVHRRTHTGEKPFSCSECEKRFLNPWSLVRHYRTHTGEKPFSCSECGKCFARSSDLTVHRRRSHTKEKPFSCSECGKCFTSSSELTVHLRTH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Gastrula zinc finger protein XlCGF17.1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2712_RALPJ
Sequence: MAIVDWPAHERPREKLLAHGPAALSDAELLAIFLRVGVPGKSAVDLARELLAHFGSLARLCHASQQEFSSINGMGPAKYAQLHALLEVARRALKEDFTQGQTFESAQSVKDFLRLTLGHRPHEVFACFFLDVRHRLIAWEELFRGTLTEARVYPREIAKRALHHNAAAVILAHNHPTGNTEPSESDVILTRELCRALAMLDVIVLDHMIVGRNHVYGFLEHGKM
What are the official names of this protein?
UPF0758 protein Rpic_2712.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: LPXB_SALTI
Sequence: MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: ENGB_SHEB9
Sequence: MTESRIDFRRAKFLISAPDIAHLDQYLPGDVGVEIAFAGRSNAGKSSALNALTEQKSLARTSKTPGRTQLINVFELDAQRRLVDLPGYGFAQVPLALKNKWQQALGEYLQKRACLSGVVVLMDIRHPLKDLDMQMIEWAVASEIPVLALLTKSDKLAQSAKMKTVNEVRLALSEFGDWVQVEPFSSLKGTGKPKVLAILNEWCHPQWLTDELDAANNAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RT12_PINSY
Sequence: MPTSNQSIRHGREKKRRTDRTRALEKCPQKRGVCLRVSTRTPKKPNSALRKIAKVRLSNRHDIFAYIPGEGHNLQEHSMVLIRGGRVKDLPGVKFHRIRGVKDLLGIPGRKRGRSKYGAERPKSK
What is the function of this protein?
Protein S12 is involved in the translation initiation step.
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SQHC_BRADU
Sequence: MDSVNATAREAKESKISESEILESSIASATQGVLGFQQSDGHWVFELEADCTIPAEYVLLRHYLAEPVDTVLEAKIGNYLRRVQGAHGGWPLVHDGEFDMSASVKAYFALKMIGDSIDAPHMVRAREAIHARGGAIHSNVFTRFMLAMFGIVTWRAVPVLPIEIMLLPFWSPFHINKISYWARTTMVPLMVIAALKPRAKNPKGVGIDELFLQDPRSIGMTAKAPHQSMAWFLLFRSLDAILRVIEPLFPKSLRKRAIDTALAFSEERLNGEDGMGAIYPPMANLVMMYDALGKDENYPPRAVTRRGIDKLLVIGDDEAYCQPCVSPVWDTTLTAHALLEAGGDKAVPAAKHGLDWLIPKQELEVKGDWAVKRPDVRPGGWAFQYNNAYYPDLDDTAVVVMSMDRMRREHGVTGYDSAIDRGREWIEGMQSDDGGWAAFDVNNLEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAKTSKHVADGVAYLRKTQHPEGSWYGRWGMNFIYGTWSVLCALNMAGVRHDDPMIRKAADWLASIQNKDGGWGEDAVSYRLDYKGWEAAPSTASQTAWALLALMAAGEVDHPAVARGVEYLIATQNEKGLWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRNTNSRVVGVGM
What is the function of this protein?
Catalyzes the cyclization of squalene into hopene.
What are the official names of this protein?
Squalene--hopene cyclase, Squalene--hopanol cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: QUEA_GEOKA
Sequence: MKVDLFDFHLPEELIAQTPLPDRAASRLMVLDKRTGAIRHETFRNIISYLNPGDCLVLNDTRVMPARLYGEKEETGGTVEVLLLKQLDGDRWETLVKPGKRVKPGTKLTFGEGKLEAVCLDTLEHGGRVLEFSYDGLFYEVLAELGEMPLPPYIKEKLDDPERYQTVYAREIGSAAAPTAGLHFTEELLDAIREKGVHIVFITLHVGLGTFRPVQVDDVEKHDMHAEFYQMSEETAETLNRVREQGGRIIAVGTTSTRTLETIAGKHNGRFVAESGWTDIFIYPGYEFKGIDGLVTNFHLPKSTLIMLVSALAGRENILHAYQVAVKERYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METZ_MYCTU
Sequence: MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIADIDRALS
What is the function of this protein?
Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
What are the official names of this protein?
O-succinylhomoserine sulfhydrylase, OSH sulfhydrylase, OSHS sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
Protein: COMR_ECOLI
Sequence: MATDSTQCVKKSRGRPKVFDRDAALDKAMKLFWQHGYEATSLADLVEATGAKAPTLYAEFTNKEGLFRAVLDRYIDRFAAKHEAQLFCEEKSVESALADYFAAIANCFTSKDTPAGCFMINNCTTLSPDSGDIANTLKSRHAMQERTLQQFLCQRQARGEIPPHCDVTHLAEFLNCIIQGMSISAREGASLEKLMQIAGTTLRLWPELVK
What is the function of this protein?
Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.
What are the official names of this protein?
HTH-type transcriptional repressor ComR, Copper outer membrane regulator.
Protein: RL23_LEIXX
Sequence: MAAVNKDPRDVIIAPVVSEKSYGLIDEGKYTFLVDPRSNKTEIKLAIESIFRVEVASVNTLNRQGKTRRTKFGLGKRKDTKRAIVTLKSGSIDIFTAVG
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PCKG_NEOFR
Sequence: MAHSVSSVVNKQLLAYIKESSELMTPKDIYVCDGSAEEYHNLCELLVKQGIFTKLNETKRPNCYLARSNPADVARVEKCTYICSEKEEDAGPTNNWMAPAEMKAKLNGLMKGCMKGRTMYVIPFSMGPIGGPISRVGVEITDSPYVVVNMCIMAKVGKKVLDLLGVDGTFVPCTHSCLAPLEEGQKDSTWPCNIDNRYIVQFPEEHRIVSVGSGYGGNALLGKKCYALRIATVLSREAGDSLAEHMLILGITNPQGKKYYITAAFPSACGKTNLAMLNATIPGWKIECVGDDIAWLKIGKDGRLWAINPESGFFGVAPGTSYKSNPNAMKSCEKDTIFTNVALTEDGDVWWEGMTKEVPKGKIITWLGKEWSADSGEPKPNLAHPNSRFTARVENVPVGDPGYYALEGVPVSAMIFGGRRENTVPLVFQSRSWKHGVLLGSSVASETTAAAEAAAGQLRFDPFAMLPFCGYNMGDYFGYWLSFADKYDEAKLPKIFHVNWFRKDNGRFLWPGYGENSRVLKWIIERVEGKEGIAKETPIGYLPAKGALDLSGLDVPEADMEKILTVDCKAYLSEVEKIRQYHSKFGSLLPKALIAELDALEQRLKAAL
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
Protein: LCSO_PURLI
Sequence: MDVAFPGMERHDEKNPPGDDGTKPTGGKKARPAIKIKWYWKGLILLVELCIGDYLLDRYVFGGVMLRTTIAYAVLARVGLDYKLHYGKDCWLARHPEEDLHHRNAQRVCTMLKWNGGLYLKAGQAVAMQGSVLPEEYQRMFGEMFDDAPHSSWSDVEKVIKQDFGGRSIEDVFGVAPSDQQGDSQFVFEREPRASASIAQVHYARLPDGRGLAVKVQRREISKQVSWDLWSMKLMTEYTAWVTGLPMGGMGQFVADRVMQETDFEHEASNSEKMADLIATDSSLRDRVYIPKVYREFTSKRVLTTEWVDAVQLWDRDAITGQVAPSRSATSDKPGLGLRLDDVMRTVVELFSAQMFSWGFVHCDPHPGNILVRQNPKRPDSAQVVLLDHGLYITMSDKLRRQYARFWKALVTNDDASLQRVSREWGMKSADAWADASLMRPYKNPSSSDDESGESWQRTKETPEERKQRMIDEAAAYLGDEGLFPRELLFLERNITIVQGNNRFLGSPVNRIKLIGSCALKAIRDDGQGKESIRERISTRVALLSLDLAFWWSAMKQYFGYGEGLEQELKEAEDRQLRETKDAVAELFGITVN
What is the function of this protein?
ABC1 family protein; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic (PubMed:27416025).  The function of lcsO within the leucinostatins biosynthesis has not been identified yet (Probable).
What are the official names of this protein?
ABC1 family protein lscO, Leucinostatins biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
Protein: HIUH1_RHIME
Sequence: MQVQDGTPGRLTTHVLDTASGRPASNLRIDLYRIEGERPELLSSTRTNDDGRCDAPLLNGSTMETGTYELRFHAGEYLGTAAERGANPFLDVIPIRFGIADRAAHYHVPLLLSPYGYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase 1, HIU hydrolase 1, HIUHase 1.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
Protein: CBR1_HUMAN
Sequence: MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
What is the function of this protein?
NADPH-dependent reductase with broad substrate specificity.  Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics.  Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231, PubMed:1921984, PubMed:17344335, PubMed:18826943).  Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).  Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.  Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).  In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267).
What are the official names of this protein?
Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], 20-beta-hydroxysteroid dehydrogenase, Alcohol dehydrogenase [NAD(P)+] CBR1, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, PG-9-KR, Prostaglandin-E(2) 9-reductase, Short chain dehydrogenase/reductase family 21C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_VIBCM
Sequence: MTDILSPLAYLCGKPTAKAKLKALPEHFQVNEVLGYSLTGHGEHLMVRIRKTGENTSFVANELAKACGVPSRAVSWAGLKDRHAVTEQWLSVHLPNGETPDFSAFLAQYPSIEILEVTRHDKKLRPGDLQGNEFVVTLSEVSDVAAVLSRLETVAELGVPNYFGSQRFGRHGNNLSEARRWGRDNVRSRNQNQRSLYLSAARSWIFNQIVSKRIEQGCFARFIEGDIALAEQQMFNVDGDLALWDQRLQAGEVAISAALAGDNALPTSGQALPLEQAELDAEPDLMALIRGNRMRHDRRAIALKAQNLSWQVQEDQITLRFSLDAGSFATSLVRELIEEIPVVRHYDQGHEQESRDSESED
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: WHIA_MYCUA
Sequence: MAMTTEVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVAGRVVVEAEVDLGSIARRLRKDIFDLYGYSAVVHVLSASGIRKNTRYVLRVANDGEALARQTGLFDMRGRPVRGLPAQVVGGSIGDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPDHLASAGKLRVEHRQVSLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKVEGIPDTESAVTPDLLEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RK36_ANGEV
Sequence: MKIRASVRKICEKCRLIRRRRRIMIICLNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LFTR_BRUA1
Sequence: MTAEAPPDDDIIEPEMLLRAYATGIFPMAEEADDPEVFWVRPEKRGVIPLDGFHIPRSLQKTIRQGIFKIRLDSNFAGVIEGCASGTGERARTWINEPIRRAYAKLFEIGHCHTVEAWYEGKLAGGLYGVTLGRAFFGESMFTRKRDASKVCLAYLVQHLSRQGFVLLDTQFTTPHLERFGALEVPRKEYEEMLERALEGIARF
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_PSEP1
Sequence: MRTLWQHCHVATMADGRYSAIEDAAIVTSAGLIEWIGPRAELAPVEADRTVDLGGAWVTPGLIDCHTHAVFGGNRSGEFEQRLQGVSYAEIAAQGGGIASTVRATRAASEDELFASARQRVQALMRDGVTTLEVKSGYGLDLANERKMLRVARRLADELPLTVRATCLAAHALPPEYAGRADDYIAHICDEMLPALAGEGLVDAVDAFCEHLAFSPAQVERLFIKARELGLPVKLHAEQLSSLHGSSLAARYQALSADHLEFMTEEDAVAMANAGTVAVLLPGAFYFLRETQLPPMDALRRHGVKIALASDLNPGTSPGLSLRLMLNMGCTCFRMTPEEALAGVTVHAATALGLGDSHGSLQVGKVADFVAWQIERPADLAYWLGGDLPKRVVRMGHEISN
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_LEPBP
Sequence: MATEFTGVWGRDSITLETGKWAKQAHGSVVYKTGNLVLLATVCAAEEPKEGQDFFPLTCEYTEKAYSVGRFPGGYFKREAKPAEHEVLLSRILDRPIRPMFPEGYFSEVQLLVQVLSADKQVSVQGHAINAASAALSVSSIPFAGPIAGARIGRIGGEFILNPTNEEITKSDLDLVVAGTKDAIVMIEGEASEISKEDMMAALRFAQEQLKFAVAMQEELAKKHGTVKKEVVLKAPDKDLHAKIREFAFDRLTLANKNADKAKRNDDIKAINKETVEHFKTLLAPEDKTKDIKHFLHELEYEVVRELVLGEGIRFDGRKTDEIRQISCEIDVLPGPHGSAVFTRGQTQSLGVMTLGTTSDNQRYETLEGSKEKNFMLHYNFPAFSVGEVRRNSGPGRREIGHGNLAERAIKKVLPTQTEFPYVIRLVSEILESNGSSSMASVCSGTLALMAGGVPISGAVSGIAMGLFSDEKGRFAVLSDIAGIEDHFGDMDFKLAGTKKGITAFQMDLKVNGLGLEVLQKAIEQAEVGRDHILGEMNKAISSVKGNLSENAPRITQKQIPKDRIGELIGPGGKMIRAIIEQSGSEISVDDSGKVTIASPSEESKEKAIAMIDGIFEEIEVGKIYDGVIKRIADFGAFVEILPGKEGLCHISKLDVKRVQSVRDIVSEGDKIKVKVISVDKMGKIDLSRKDVLLDN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T106A_MOUSE
Sequence: MGKAVSQLTSRKDEDKPILPDNPAMASQAANYFSTGSSKPAHSCMPYEKAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPITVTQLTAEVLHQASVVGQVTSSLRLHIGPLASEQMPYEVASRILDENTYKICTWPKIRVHHILLNIQGSLTCSFLSHPQQLPFESFEYVDCRENMSLPHLELPRPA
What is the function of this protein?
Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746).  Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746).  May play a role in inhibition of proliferation and migration (By similarity).
What are the official names of this protein?
Transmembrane protein 106A.
What is the protein family that this protein belongs to?
Belongs to the TMEM106 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CYB_ISOBI
Sequence: MTNMRKSHPLIKMVNHSFIDLPTPSNISAWWNFGSLLGVCLMLQIITGLFLAMHYTADTLTAFSSXTHICRDVNYGWLIRYAHANGASVFFIFLYLHIGRGIYYGSYQFKETWNIGVILLLMVMGTAFMGYVLPWGQMSFWGATVITNLLSAIPYMGPTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVMIHLLFLHETGSNNPSGLNSDSDKIPFHPYYSIKDILGLMFMLLLLLTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALALSILILMLFPIMHVSKQRSMSFRPFSQCLLWTLVANLIILTWIGGQPVEHPFIIIGQLASISYFCIILILMPTSSFMENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: OTUD3_MOUSE
Sequence: MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPDPGGSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIRQREDFEPFVEDDIPFEKHVASLSKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKGSTRELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDGANKKEKMKTKGVDVKDGLRDDVEDAVHKVGSATGCTDFNLIVQNLEAENYNIKSAITALLQVNQGTGNDAEENHEPGDRVKQRGPSREEAGSGRRLSGNQGRNEGRMETSEARASPAEESKAHKSQLPKVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDTGRSEADMNTQVTLVKTFAALNI
What is the function of this protein?
Deubiquitinating enzyme that hydrolyzes 'Lys-6'-, 'Lys-11'- and 'Lys-48' linked polyubiquitin.  Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:35675826).  Important regulator of energy metabolism.  Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation.  In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826).
What are the official names of this protein?
OTU domain-containing protein 3.
Protein: LRC49_MOUSE
Sequence: MIPGKYRSVSGRAANNVNCGLHLVIQTSSLSDKNKVEFRLNRETPPFPGRLLQHDLERNYSSRQGDHISLVSSSMPAFPILQRSSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVPKKEEEKKRESHKQSLLKEKKRLTINNVARKWDLQQRVANIASTQDRKDSESPPQESCQLDGGNISAFPEEAGSLDAGLSSALQGLSVTETHLVEIDGETLSLYGSGALECLDRNWSVQTAGMVTTVSFTFIEFDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRMISILGDARKKQFRYLLESKGKKPGIICEETSDSKRFLGENTNRATLNYTTREFYHEKLEEIKDKKKFCRLYVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSYMKLCLQQITDQK
What is the function of this protein?
Subunit of the tubulin polyglutamylase complex (TPGC).  The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.
What are the official names of this protein?
Leucine-rich repeat-containing protein 49, Tubulin polyglutamylase complex subunit 4, PGs4, p79.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Associated with microtubules.
Protein: URE3_CORK4
Sequence: MNLSPRETDKLLVFLAAQVAQRRRERGVKLNHPEAIALISDAVIEAARDGKSVAEAMHIGTTVLTADEVLDEVPDMVSLVQVEATFPDGTKLVSVHDPIRH
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_SACEN
Sequence: MTTTEKIVPRLKTRYRDEIRQALNEEFHYSNAMQVPGVVKVVVNMGVGDAARDSKLIEGAVRDLATITGQKPEIRKARKSIAQFKLREGMPIGARVTLRGDRMWEFIDRLVTIALPRIRDFRGLSGKQFDGKGNYTFGLNEQSMFHEIDPDSIDRPRGMDITVVTTANTDEEGRVLLRRLGFPFKEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RS19_MYCMS
Sequence: MARSLKKGPFVDESLFKKVTAAKDGEVIKTWSRRSTIFPEFIGKTFGVYNGKEFIPVYITEDMVGNKLGEFAPTRKFGGHGDDKGKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ATPG_RHOPA
Sequence: MASLKDMRVRIASTKATQKITKAMQMVAASKLRRAQMAAEAARPYAEKMEAVISNIAGAAAGSPGAPVLLAGNGKDQVHLLLVCTGERGLSGAFNSSIVRLARERAYELMSQGKTVKFFCVGRKGYEQLRRNFEKQIIDNVELRSVRQIGFVNAEDIAKKVIARFNAGEFDVCTLFYSRFKSVISQIPTAQQLIPLEVTAPAAGTVATSYEYEPEEDEILSGLLPRNLAVQIFRALLENNASFYGAQMSAMDNATRNAGEMIRKQTLVYNRTRQAMITKELIEIISGAEAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.