PharMolix/UniProtQA huggingface dataset:
Protein: RL21_BACC0
Sequence: MYAIIETGGKQIKVEAGQAIYIEKLDVEAGETVTFDKVLFVGGENVKVGSPVVEGATVTAKVEKQGRAKKIIVFKYKAKKNNRKKQGHRQPYTKLVVEAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HDA_SHIB3
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: HTPX_VIBVY
Sequence: MKRVMLFLITNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLMMSKGMALRSVGGMVIESPRNETEHWLLETVSRQAQQAGIGMPTVAIYDSPDINAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANMVASNNSDEEGEGSNMMVYFAVSIALELVFGFLASFITMWYSRHREFHADAGAARLVGKEKMIAALERLKMSQESKLDGTMMAFGINGKQSLTELLMSHPPLDKRIAALRNF
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASZ1_PANTR
Sequence: MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKGLLPIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDILKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFLLKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLKDLIQKLQNERESDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRK
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.  Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons.  May act by mediating protein-protein interactions during germ cell maturation (By similarity).
What are the official names of this protein?
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity).
Protein: KLF4_MOUSE
Sequence: MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
What is the function of this protein?
Transcription factor; can act both as activator and as repressor.  Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216).  Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216).  Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216).  Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216).  Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.  Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.  Contributes to the down-regulation of p53/TP53 transcription (By similarity).
What are the official names of this protein?
Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCPP_METTH
Sequence: MDSVVFYMKVNVGSGNPVKVRATENVLGLIYGNVEVRGVEVESGVPDQPVGLEETVRGAVNRARRAFRDCELSVGIESGLHRVPETITGFVDLQWCAIYDGEHITLGVSAGFEYPPMVVEEVLAGREVGDVMDELTGVDELGRKRGAVSFLSGGLLDRTGNTEQCVLMAMIPRMNPSLYGLK
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Probable inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: SULA_PSEAE
Sequence: MQTSHSLPSAQLPLFQEAFWASNGAPLLDDVIDSPSSASIEEPAAFSELSLSGLPGHCLTLLAPILRELSEEQDARWLTLIAPPASLTHEWLRRAGLNRERILLLQAKDNAAALALSCEALRLGRSHTVVSWLEPLSRAARKQLSRAAQLGQAQSLNIRLG
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity).
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: CDC67_HALSA
Sequence: MTDDRSTDERRTADRDFEVDLDDVLDDEDDDEGLFDDLLSGEPIFENKEVLRPSYTPHELPHRNDQINNMATILVAALRGETPSNILIYGKTGTGKTASAKFVSQELEKTSKKYDVPCEVEYINCEVTDTQYRVLAQLANTFIDQNRAFVDARIADLSDLRAQADDDPNALEIGGSPGDDRTGNESSEGSDVSDSFSDLRERFDSVAEIDDRIDSLEADKAEMEQVPMTGWPTDRVYATFFDAVDYVERVAVIMLDEIDKLVEKSGDDTLYNLSRMNSELDNSRVSIIGISNDLKFTDFLDPRVKSSLGEEEIVFPPYDANQLRDILQHRSDVAFKADALSDDVLPLCAAFAAQEHGDARRALDLLRTAGELAERDQAENVTEDHVRRAQDKIELDRVVEVVRTLPTQSKLVLYAILLLEDNGVHNVNTGEVYNIYKTLCDELDADVLTQRRVTDLISELDMLGIVNAVVVSKGRYGRTKEISLSVPVEETEAVLEADSRLSDIEDITPFVQARFENN
What is the function of this protein?
Involved in regulation of DNA replication.  Required to initiate DNA replication of the circular chromosome at a nearby autonomously replicating sequence (ARS) oriC1.
What are the official names of this protein?
ORC1-type DNA replication protein 7.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: MTDRP_MYCTU
Sequence: MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
What is the function of this protein?
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon (PubMed:30642988).  Possesses both phosphatase and kinase activities (PubMed:30642988, PubMed:19700407).  The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity (PubMed:19700407).
What are the official names of this protein?
Multidomain regulatory protein Rv1364c, Anti-sigma-F factor Rv1364c, Anti-SigF factor, Protein-serine/threonine phosphatase, Putative multidomain regulator of SigF, MursiF, Serine/threonine-protein kinase.
Protein: SYM_SHEDO
Sequence: MTQSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRFQKMRGHECHYICADDAHGTPIMLKAQQLGIAPEAMIAQVQIEHEQDFADFNVAFDNFHSTHSEENRELASDIYIKLRDAGHIKTKTISQLYDPEKSMFLPDRFVKGTCPKCKSDDQYGDNCDSCGATYSTTDLINPRSAVSGATPVMKDTEHFFFDLPAFEGMLKEWIHSGSLQSEMANKLNEWFEQGLQQWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNFCAKRGDINFDDFWAKDSTAEVYHFIGKDIVYFHSLFWPAMLEGAGLRKPTSVYAHGYVTVNGAKMSKSKGTFIKARTYLDHLDPEYLRYYYAAKLSSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFISKRFDGKLANVTDNSLAESFIAKQEVIAEFYEAREYGKAMREIMAMADIANGFVAEQAPWQLVKDDDKQAQAHEVCSIALNLFRILTTYLKPVLPRLSQDVEAFMQLELTWDNLAKDMTAHEIAPFKAMMQRVDLDKVAAMVDASKDNLQPTEAPKADKKADKKVEKKATTGDPLTDDPISDEISFEDFAKLDLRIALIAKAEHVADADKLLKLQLDLGGVTKQVFAGIKSAYAPEDLEGKLTVMVANLAPRKMRFGMSEGMVLAAGPGGDELWILEPHQGAKPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_ACICJ
Sequence: MDRIRIRGGRPLEGVIDISGAKNSALKVMVAGLLTDERLELENVPALADVATMAQLLAQHGIAVEETGAKQLSVGGAITNTEAPYDIVRKMRASILVLGPLLARTGEARVSLPGGCAIGTRPVDLHLKGLEAMGAEIALDGGYINARAPKGLHGATITFPFVSVGATEQLLLTATLAEGETVLVNAAREPEIGDLADCLNKMGADISGIGSDRLTIRGVKALHGARHTILPDRIEAGTYACAAAITGGGVLLRGARMFDLGALASTLGEAGVDVTEVAEGVTVSRRNGLHGTDAMTEPFPGFVTDMQAQFMTLMAVAEGASMITETIFENRFMHVPELNRMGARINVHGSSAIVRGVPGLSGAPVMATDLRASFSLVLAGLAAKGETIVNRVYHLDRGYEAVERKLAACGADIERLRD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAG_BIV29
Sequence: MKRRELEKKLRKVRVTPQQDKYYTIGNLQWAIRMINLMGIKCVCDEECSAAEVALIITQFSALDLENSPIRGKEEVAIKNTLKVFWSLLAGYKPESTETALGYWEAFTYREREARADKEGEIKSIYPSLTQNTQNKKQTSNQTNTQSLPAITTQDGTPRFDPDLMKQLKIWSDATERNGVDLHAVNILGVITANLVQEEIKLLLNSTPKWRLDVQLIESKVREKENAHRTWKQHHPEAPKTDEIIGKGLSSAEQATLISVECRETFRQWVLQAAMEVAQAKHATPGPINIHQGPKEPYTDFINRLVAALEGMAAPETTKEYLLQHLSIDHANEDCQSILRPLGPNTPMEKKLEACRVVGSQKSKMQFLVAAMKEMGIQSPIPAVLPHTPEAYASQTSGPEDGRRCYGCGKTGHLKRNCKQQKCYHCGKPGHQARNCRSKNGKCSSAPYGQRSQPQNNFHQSNMSSVTPSAPPLILD
What is the function of this protein?
Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA.  Binds these RNAs through its zinc fingers (By similarity).
What are the official names of this protein?
Gag polyprotein, Pr53Gag.
What is the protein family that this protein belongs to?
Belongs to the bovine lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p16]: Virion. SUBCELLULAR LOCATION: [Capsid protein p26]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p13]: Virion.
Protein: CHS1_ASPNG
Sequence: DFLFARTMIGVFKNIEYMCSRTSSKTWGKDAWKKIVVCVISDGRAKINPRTRAVLAGLGCYQDGIAKQQVNGKDVTAHIYEYTTQVGLELKGGQVSLKPRTGCPVQMIFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLLDAGTRXGKDSIYHLWKXFDVDPMCGGACGEIKVMXSHGKKLLNPLVAG
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 1, Chitin-UDP acetyl-glucosaminyl transferase 1, Class-I chitin synthase 1.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family. Class I subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IL23A_PIG
Sequence: MLGSRAVMLMLLLLLLPWTSQGRAVPEGSSPAWAQGQQLSQQLCTLAWTAHLPMGHVDLPREEGDDETTSEVPHIQCGDGCDPQGLRDNSQSCLQRIHQGLVFYEKLLGSDIFTGEPSLHPDGSVGQLHASLLGLRQLLQPEGHHWETEQTPSPSPSQPWQRLLLRLKILRSLQAFVAVAARVFAHGAATLSQ
What is the function of this protein?
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity.  Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4.  This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A.  In turn, participates in the early and effective intracellular bacterial clearance.  Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
What are the official names of this protein?
Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted upon association with IL12B.
Protein: SYN_CLOP1
Sequence: MKDVVLVKSLYRNTSEYSDKKVKISGWIRTLRASNAFGFIEVNDGSFFKNVQVVFDSAKISNYKEISKLPISSSISVIGTLVETPDSKQPFEIQAEEIIVEGMSDSDYPLQKKRHTFEYLRTIAHLRPRSNAFSATFRVRSVAAYAIHKFFQDQGFVYTHTPILTGSDCEGAGEMFRVTTLDMMAPPIAEEGGIDFSQDFFGKETNLTVSGQLNAECFALAFRNIYTFGPTFRAENSNTVKHAAEFWMIEPEMAFADLIDDMEVAENMLKYVIKYVMDECPEEIAFFNQFVDKGLLERLNHVVNSEFGKVTYTEAVKLLQESGKEFEYPVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDIKAFYMRLNEDGKTVAAMDCLVPGIGEIIGGSQREERLDVLKARMAELNLNEEDYWWYLELRKYGETVHSGFGLGFERLIMYITGMANIRDVIPFPRTTGTAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_KOCRD
Sequence: MAKKSKIAKNEQRKVIVERYAAKRAELKKTLVDENASPEAREEARLGLQKLPRDASPIRVRNRDQIDGRPRGTFQRFGISRVRFRDMAHRGELPGIYKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RNK_ECOLI
Sequence: MSRPTIIINDLDAERIDILLEQPAYAGLPIADALNAELDRAQMCSPEEMPHDVVTMNSRVKFRNLSDGEVRVRTLVYPAKMTDSNTQLSVMAPVGAALLGLRVGDSIHWELPGGVATHLEVLELEYQPEAAGDYLL
What is the function of this protein?
May act as an anti-Gre factor.  Regulates the level of the nucleoside diphosphate kinase Ndk.
What are the official names of this protein?
Regulator of nucleoside diphosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the Rnk family.
Protein: BID_PIG
Sequence: MDSKVSNGSSLQDERITNLLVFGFLQSCPHASFHKELEVLGHELPVHTSGSDELQTDGNRCSYFMEDAAETDSESQEAVIRDIARHLARIGDRMEYGIRPGLVDSLAAQFRNQSLSEEDRRQGLAAVLQQLVHSYPADMGQEKTLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLTYLRNLVQSEMD
What is the function of this protein?
Induces caspase activation and apoptosis (By similarity).  Allows the release of cytochrome c (By similarity).
What are the official names of this protein?
BH3-interacting domain death agonist, p22 BID, BID.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. Note=When uncleaved, it is predominantly cytoplasmic (By similarity). SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Note=Associated with the mitochondrial membrane.
Protein: PDUW_SALTY
Sequence: MSYKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIINSLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIYPLPWHYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTRSGDIDPSILPWIAQRESKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQRNATFIQTENALVKVAVINTNEELMIAQDVMRIALPATEGLCVPA
What is the function of this protein?
Works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD).  Ectopic expression partially complements a cobB deletion allowing some growth on propionate (PubMed:12700259).  Restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions (PubMed:26448059).
What are the official names of this protein?
Propionate kinase PduW.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family. PduW subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_BACAC
Sequence: MPKGSGKVIAQNKKAFHDYFIEETYEAGLVLQGTEIKSIRAGRVNLKDAFARVHNGEVWVHNMHISTYEQGNRFNHDPLRTRKLLLHKKEIEKLAGASKETGYALVPVRIYLKNGFAKMALGLAKGKKQYDKRHDLKEKEAKREIARAFRDRQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CP4X1_MOUSE
Sequence: MEASWLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKMQYLHQLLTPCIGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKIIQDRKKILKNQVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKLLEC
What is the function of this protein?
A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling.  Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Cytochrome P450 4X1, CYPIVX1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Protein: WWP1_CAEEL
Sequence: MARNEPSSQQPSSSGSNGTPAQQNGSAKPSKVTVKVVNASFTKAADCYVEITSDTSSAAPKKTTVKKKTMAPEWNEHLNVHANESSTISFRLLQKAKLFDDTCLGMAKLKLSSLTRNENGEFKNDINNISLLAKDSSKIGTLNIIFSGYPERKRRSAGVRAETAASASSEASTSNGVATSSSARRPATAKRDTLAAPTSTAAAAAAATAGGTPAAGAEEQLPDGWEMRFDQYGRKYYVDHTTKSTTWERPSTQPLPQGWEMRRDPRGRVYYVDHNTRTTTWQRPTADMLEAHEQWQSGRDQAMLQWEQRFLLQQNNFSADDPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGNE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:24805825, PubMed:19553937).  Ubiquitinates klf-1 (PubMed:24805825).  Required for diet restriction-mediated lifespan extension, acting in concert with Kruppel-like factor klf-1 in the intestine to perhaps modulate genes involved in lipid metabolism (PubMed:24805825, PubMed:19553937).  Probably acting downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway, plays a role in the immune response to infection by the Gram-negative bacterium P. aeruginosa, at least partly in response to bacterial pore-forming toxins (PubMed:20209166).
What are the official names of this protein?
E3 ubiquitin-protein ligase wwp-1.