PharMolix/UniProtQA huggingface dataset:
Protein: NACA_YEAST
Sequence: MSAIPENANVTVLNKNEKKARELIGKLGLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGNYVVFGEAKVDNFTQKLAAAQQQAQASGIMPSNEDVATKSPEDIQADMQAAAEGSVNAAAEEDDEEGEVDAGDLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD2 may also be involved in transcription regulation.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC, GAL4 DNA-binding enhancer protein 2.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. Nuclear import may occur via redundant pathways including one requiring the karyopherins PSE1 and KAP123, which also participate in nuclear import of ribosomal subunits.
Protein: RL32_FRASN
Sequence: MAVPKRRTSRSNTRSRRAQWKAKAPALAKCSRGHTIRPHTMCPTCGRYNDRQVLDV
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: ATPA_GEODF
Sequence: MEIRAEEISEIIRKQIKEYGSEVEVAETGTIISIGDGIARIHGLDKAMAGELLEFPGGISGMALNLEEDNVGAAILGEFSEIKEGDTVKRTNRIVEVPVGEALIGRVVNAIGQPIDGKGPINTDKFGKVEVKAPGIVKRKSVHQPMQTGLKAIDAMVPIGRGQRELIIGDRQTGKTAVAIDTIINQKGGDVVCIYVAIGQKRSTVAQVVSKLQEHGAMDYTIIVAATASEPAPLQFISPYTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERACKVSDACGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLSLAQYREMAAFAQFGSDLDKATQMQLARGERLVEVLKQPQYRPIPNEKQVLIIFAANNGYIDEYPVASLGRYESELYSFFDARKSDLLAELRDKKAIDDDIKAKIVSALEEFKKEFTA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EF1B_METMA
Sequence: MGDVAAKLKIMPESVDTDLVGLKENLKNVIPAGAQLHGDIVEEPIAFGLKALIVTLIVNDEEGGTEPAEEAFAKVSGVENVQVLEAYRI
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: UPPP_PECAS
Sequence: MTDLHSLLIAFILGVVEGLTEFLPVSSTGHMIIVGHWLGFVDEKAKTFEVIIQLGSILAVVVMFWRRLFGLIGIHFGKVPHEGKTSGRLKLTHILLAMIPAVVLGLIFHDVIKSLFYPQNVMYSLVIGGFLLLAAEWFKPKEPRAVGLDDITHRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFILAVPMMMGATVLDLYKSWHFLSLADVPMFAVGFVTAFVVALIAIKTFLKIIKRISFIPFAIYRFIVAGVVYMVFM
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GUF1_TALSN
Sequence: MRGCLQVLRWLSTSPARRPVSSGLRLRSYEIVSPSILRPFTSTVRRQAQASRNVSDLEKRIAEIPIERFRNFCIVAHVDHGKSTLSDRLLELTGVIEPGSNKQVLDKLDVERERGITVKAQTCTMLYNHNGEDYLLHLIDTPGHVDFRAEVSRSYASCGGALLLVDASQGVQAQTVANFYLAFAQGLELVPVLNKVDLPSADPERALEQMRSSFELDTDNAIKVSAKTGLNVEQLLPTVIERIPAPVGDHTNALRMLLVDSWYSTYKGVILLVRVFDGEIRAGDQVVSFATGLKYYVGEVGIMYPDQTPQSVLRAGQVGYIYFNPGMKRSKEAKIGDTFTKVGYEKKVEPLPGFEEPKSMVFVAAYPSDADHFEHLEDSVNQLILNDRSITVQKESSEALGAGFRLGFLGTLHCSVFEDRLRHEHGASILITPPTVPVKVIYKDGKEVTVTNPAHFPDEDEIRAKVAELREPYVMATLTFPDEYLGKVIELCEANRGIQHTLEYFTSSQVILKYELPLGQLVEDFFGKLKGSTKGYATLDYEEAGWKASNIVKLQLLVNKKPVDAVARIVHYSQVERLGKQWVTKFKEHVDRQMFEIIIQAAVGRKVVARETIKPYRKDVLAKLHASDVSRRRKLLEKQKEGRKRLNAIGNVVIDHSAFQAFLSK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor guf1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase guf1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: GLMM_ACTP2
Sequence: MAERKYFGTDGVRGKVGQFPITPDFALKLGWAAGKILATQGTKQVLIGKDTRISGYMLESALEAGLAAAGLSAAFVGPMPTPAIAYLTRTFRAEAGIVISASHNPYYDNGIKFFSSVGEKLPDEVEEAIEALLDQPMDCVESAQLGKAMRINDAAGRYIEFCKGTFPANASLKGYKIVVDCANGATYHIAPNVMRELGAEVIEIGTKPDGLNINEKCGATDIKALQKVVVESGADVGLAYDGDGDRIMMVDHLGNKVDGDQILFIIAREALRSGKLHGGVVGTLMSNMGLEVALKHLAIPFTRANVGDRYVLEQLKEKGWKLGGENSGHIIVLDKNTTGDGIIASLEVLAAMEAHKMSLNDLARAVPLFPQVLINVRFEGGKNPLESDAVKAVAADVEKRLAGKGRILLRKSGTEPLIRVMVECEDGALAQSCAEEIVEAVKSN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: FRBG_BLOB1
Sequence: MCSIADLDGIGPFSSNPQCGHLSFTLLFEEAVLAAVPLGLCVVLALLRVRQLRLQSPKARRDRLYYAKLTALFLLASVQLVQLIQWTRPSTPKTRASIAIAAVSFASTIVFIGLCHLEHIRSAKPSDLLTLYFVTCIAFDIIRTRTLWIVSGGTAVASTFTVGLVLRLLFALLESRPKTRALQRQYLRESPEARTSLINRLFFWWVNPLLWTGFKRILDPGHLFNLDRHISSSHLFHVSAQRLNDTDLSKSYAVLLLCLREYKWTFLAGVLPRLALTGFTFAQPFLVTRFLSYESNRDARDAGATGTWLIVAYAGVYIGIAISQAGYIHQTFRFITMVRGSLLTLLYHDTMNKGSSAGIDPTSAELTLVSADIEKIQMGLQTMHQAWASFVDICLATWLLERHLGLATIPSVGFSLLCVVFGGGVAVMAGSRQTLWLEAIQKRLGLTSDVINMFKSVKMTALVNISAARVLELRDKEITVSKKFRRCLVFMVSLTYLSNVFAPIIGFTTYTLAPAIHKNNILDSARAFSSLTIFALLTEGVGSFVHSAVNLMLAVSSFERYRTTLLEKHTWHESKKASRRWTLTAPPLLENTDAEQWALEVLAATADAHTPPDDKQVCIQARDTNIGWSSEKIVVQSLSLVVRKREITLVTGPTNSGKSTLLRAMLGEAWIEGPALHRHFDRAAYCDQIPWLANKTIRQNILGGSPVDEDWYETTLQACQLKPDLGRLAQGDQTVVGNEGSRLSGGQRTRVALARAVYSRLDIMLLDDITSGLDPNTTKSIVEALFGKDGLFRRAGQTVVVASNNASFLSLADQVVDLGSGSPKVTRRNVESSSPVTAHVHNQTSPKGSRIDSARGSLDEISVADFRLEEPKREPRRLDSDTSIYMYYVRTVGVVNTAVFLALCMALVFAMVFPSIWVAWWVEANARGETNQLAKYLLVYFFLGVAALIALIGGGSHLMLRMVPRSARILHRALLDAVVVAPVPFMTRNDAGETLNRFSQDLEIIDTDVPLSGFTTLFAFITCIAQAIVVCVSSPFVTAGMVPTLVLVYFIQKFYLRTSPQLRALDLEAKAPLIGHMQETLRGLATIRAFGWAEDYEERNMRLVDESQKPFYQLTCIQRWLGLVLDLVVAGIAILLAIVIVSDKNGGATSGFLGIALTSLVSFGLNLGGFIGGWTGLETALTAVARVKRFSADTAKEDLPEECQTPPTDWPQRGEIVFDDVTASYGPGTTDVLSNVSFRISPGEKIGIIGRTGSGKSSLVSTLSRTLDLISGSILIDSIPLSSLPRDTVRQALINMPQDAFVLHGSIRTNVDPRSRLTDEAITEVLTELGLWPILAPLGGLDADAVSALPAQGLKQLLCFARVLAQPGRVMVLDEATSRLDPEASAKVKQAIMRRSEGRTLLTVAHKIDELDGYDRIMVVDAGKVVAFDTPGAVQGYLSSSSPTSSPTCSSSAAALSSGAHRVAAVGVLGTEAGRA
What is the function of this protein?
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the antifungal antibiotic FR901469, an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity against the pathogenes Candida albicans and Aspergillus fumigatus (PubMed:27660098).  FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098).  Probably involved in the secretion of FR901469 (Probable).
What are the official names of this protein?
ABC-type transporter frbG, FR901469 biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH034_DANRE
Sequence: MASLQQSRIQSYLEKNKIGPLFEEMMTKLITETPDHPIPFLIGHLQTKQESPGRIQRTLSGSAALWAEGSSEYKGTRRDSRGYEKPWQIHPKKPKKSKSDLAVSNISPPSPESKSLPRSILRPTWDWRTKPESRGFDELNHILLESKKLGKALENLSRSIAVSDDFDLDPRAYNSVLRPRVVGEWVGREEEDLDPLAAEMFQPPVPRAKTEGWTSKDNSPVGSLKMETKGKGLKQQQQNHKKLLAAMLSQDSFDSMPDSAPSVTEDEMEDEDDAMELLEDLDDLRMEGVTGLLQSGSKFSQGRSSYYTEPQAKVTLNICSRCARLQGDSLTARTEEEPERHVPEQAVPEVPCPLPTVTETLTATEDLQTASQVTGLRHPVWASDVKPIRGTSPQTARRALQLQDSLFSKELENMGKHLAEVEKDLAKLAEQGKLNRSPNSPHRSLLLPPLFHTTNTLPVLGQTSRPQSPSSLSSKTTGLPLHNPKPTSLMTDRTSPSNSSSRAQTPSRPITPNSLMMRSFTAAGHGNKERVYGRSRSRPVTPTGQITRPILTPPGLSTTDLYGGLWSTLTEDEFYQQLQAVRKPWRIPSDAESDCLDPPEQDKCEFYTSDPSHSLKTL
What are the official names of this protein?
Uncharacterized protein C8orf34 homolog.
Protein: YRC3_CAEEL
Sequence: MESVTRHRADMISFFTFDSYISIVGVAYTAVGLLGVFCNVTTVIMILTNRVFRLSAYTIMANVALADSIVMLIAGVACGMDVMWPNPNDLTSFIPSLEEPYQKIAPVSLRNDSKTDSSAAGFETGNIHAVLSFSFVAAWTAGVISYAMLGTNRCIAICYYGTKARALNQVSVAVACSASTWIVGIAAALVGTLSQPMIGIQRTMWSISFLEPRPHTTLFFTLLCAANLLGLGAQWVCSTLVLLKIRQVKKKISKNKLNQNSANRFRKQVILALNEIIVTGNFKARLTFQFFYPSILCTISTFLFFIKPYAFEYLSGWQLVILHLLWLCNHTCNPFIYAYFNDRMRLTYKEILTCAAIRYQIRKRRSSHPFRMHGRHNVSKRSNAAGMKSTRISARSGRTNRDGNFVRNSLQMQSRDFEQLCEFIMRVNPLYDSSEGWRESSDDEPFQPEFTKELESAHNQGGSSRFDSEREAKSIVLDLGRQTVEHWVKFAKKASI
What are the official names of this protein?
Probable G-protein coupled receptor K01A12.3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTH_SALNS
Sequence: MAIKLIVGLANPGAEYAATRHNAGAWYVDLLAERLRAPLREEPKFFGYTSRITLEGEDVRLLVPTTFMNLSGKAVGAMASFYRIQPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRVGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTELWFKEGLAKATSRLHTFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_LACPL
Sequence: MAITEPILKEAQERMKKAEAALQRELGNIRAGRANASLLNRISADYYGAQTPLNQMAAITVPEPRVLMVTPFDKSALKEIEKAILASDLGISPANDGSAIRLVIPQLTEERRKELAKDVKAEGERAKVAVRNVRRDAMEALKKGHKDGQFTDDQLHQLEDQAQKLTDQAGKDVDAIVADKEKEILEG
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_SHESR
Sequence: MARYFILAVALLLTACSSTSKKPIADDPFYAPVYPEAPPTKIAATGSIYQDSQAASLYSDIRAHKVGDIITIVLKEATQAKKSAGNQIKKGSDMSLDPIYAGGSNVSIGGVPLDLRYKDSMNTKRESDADQSNSLDGSISANVMQVLNNGNLVVRGEKWISINNGDEFIRVTGIVRSQDIKPDNTIDSTRMANARIQYSGTGTFADAQKVGWLSQFFMSDWWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: ATPF_METPP
Sequence: MSLNATLFAQLVVFFILAWFTMKFVWPPITKALDERASKIADGLAAADRAKTELASANKRVEEQLASVRDENARRLADAEKRALAIVEDAKKRATEEGSKIVAAAKSEAEQQLVQARESLREQVAALAVKGAEQILKREVNAGVHADLLSRLKTEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NUOA_CYTH3
Sequence: MNNKYAEYLPIAIQLMVTLGFISVTLLSSWLLGPKVKSKKKLDAFESGLDPVGNARVQFSIKYFLVATLFVLFDVEVIFFYPWAVNFNYFAEAVNKWEGFVKMLLFMTSLLIGFIYVIKKKALDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PB2_I01A1
Sequence: SVKKEEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMVGILPDMTPSTEMSLRGVRVSKMGVDEYSSTERVIVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELINLAKGEKANVLIGQGDVVLVMKRKRDSS
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: PREP_XENLA
Sequence: MIRQCWAGLRLCRALYQTSYRWHGKSACERALRYSPGESIHGFTVNEVTPVPELFLTAVKLSHDNTGAKYLHVAREDSNNLFSVQFRTTPLDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNAKDFQNLLSVYLDAVFFPCLRELDFWQEGWRLEHENPEDPNSPLIFKGIVFNEMKGAFTDNEKVFSQHLQNKLLPDHTYSVVSGGEPLNIPDLTWEQLKEFHATHYHPSNARFFTYGNLPLEMHLKQIHEDALSKFGRIDPKTSVPPQERWQSPREYSISCGVDSFASDPEKQTMVSVNFLLSEITDSFEAFTLSLLSSLMVDGPNSPFYKALIEANLGTDFSPDTGFNNYTRETYFSIGLQGINKEDSEKVKHIINRTINEIAEQGIEPERIEALLHKLEIQMKHQSTSFGLTLASYIASCWNHEGDPVDLLKIGDKISRFRQCLKENPKFLQDKVKQYFQVNQHRMMLSMSPDEQHYDKEEQLEEEKLTQKVKALSEEERKQIYEKGLELISLQSKPQDFSCLPALKVSDIEPQIPLTDLEIAYAGDVPVQYCTQPTNGMVYFRAVSSLNTLPEELKPYVPLFCSVITKLGCGVYNYREQAQQMELTTGGMSVCPHIISDDSSLDTYEQGILFSSLCLDRNMPDMMHLWSEIFNSPHFDDEERLRVLVRMSAQEMSNGIPDSGHVYASIRASRTLTPTGELQELFSGMDQVKMIKRIAEMPDMGSILRKLSRIRKYVLLSDNMRCSINAAPQQMETASKEMEHFLTGITRSKKERKAIRPHVVEKSSNPSPSGSEISRTATRKLVGDPTFKPCQMKTHFCLSFPVNYIGECVRTVPYTHPDYASLRILARIMTAKFLHGEIREKGGAYGGGAKLSFDGIFGFYSYRDPNSLSTLSTFQKATDWAKSGQFSQQDVDEAKLSVFSAVDSPIAPSDKGMNHFLHGISDEMKQRHREELFAVTHSDLTNASNKYLTAGQCTRGTAILGPENKNIAKDPSWIIR
What is the function of this protein?
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing.  Has an ATP-independent activity.  Specifically cleaves peptides in the range of 5 to 65 residues.  Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.  Degrades the transit peptides of mitochondrial proteins after their cleavage.  Also degrades other unstructured peptides.
What are the official names of this protein?
Presequence protease, mitochondrial, Pitrilysin metalloproteinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RS2_SORC5
Sequence: MQAVAPQPGDFPLPLRSLLDAGVHFGHQTKRWNPKMRPFIYGARNGIHIIDLDQTTRLFKRAYDFLTDAVGRGGHVLFVGTKRQAQDIVQEEARRAGMYFVTNRWLGGTLTNFRTIKQGLDRLRTLERMKEDGTYEQLLKKEVVRLEKERERLEKYLGGLKGMGGLPAAIFVIDPHQESIAISEARKLNVPVVAITDTNCDPDLVDFVIPGNDDAIRSIRLITARVADACVEGAQRRKDHGEGGQQAAGGGRGQRDEINVYQGGRGGRGGGPRQQQAS
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: VTC4_YEAST
Sequence: MKFGEHLSKSLIRQYSYYYISYDDLKTELEDNLSKNNGQWTQELETDFLESLEIELDKVYTFCKVKHSEVFRRVKEVQEQVQHTVRLLDSNNPPTQLDFEILEEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVRLDSKPFFKENYDELVVKISQLYDIARTSGRPIKGDSSAGGKQQNFVRQTTKYWVHPDNITELKLIILKHLPVLVFNTNKEFEREDSAITSIYFDNENLDLYYGRLRKDEGAEAHRLRWYGGMSTDTIFVERKTHREDWTGEKSVKARFALKERHVNDFLKGKYTVDQVFAKMRKEGKKPMNEIENLEALASEIQYVMLKKKLRPVVRSFYNRTAFQLPGDARVRISLDTELTMVREDNFDGVDRTHKNWRRTDIGVDWPFKQLDDKDICRFPYAVLEVKLQTQLGQEPPEWVRELVGSHLVEPVPKFSKFIHGVATLLNDKVDSIPFWLPQMDVDIRKPPLPTNIEITRPGRSDNEDNDFDEDDEDDAALVAAMTNAPGNSLDIEESVGYGATSAPTSNTNHVVESANAAYYQRKIRNAENPISKKYYEIVAFFDHYFNGDQISKIPKGTTFDTQIRAPPGKTICVPVRVEPKVYFATERTYLSWLSISILLGGVSTTLLTYGSPTAMIGSIGFFITSLAVLIRTVMVYAKRVVNIRLKRAVDYEDKIGPGMVSVFLILSILFSFFCNLVAK
What is the function of this protein?
Catalytic subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046).  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046).  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834).  The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419, PubMed:12584253).  Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419).  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.  Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).  The VTC complex is required for microautophagy.  It is a constituent of autophagic tubes and is required for scission of microautophagic vesicles from these tubes (PubMed:17079729).
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 4, Phosphate metabolism protein 3, Polyphosphate kinase, SPX-dependent polyphosphate polymerase VTC subunit 4, Vacuolar membrane polyphosphate polymerase catalytic subunit, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC4 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: GDF15_RAT
Sequence: MALRALHAQPTGGPQLRFLLFLLLLLLLLSWPSQGDALALPEQRRSLSESQLNPDELRGRFQDLLSRLHANQSREDSNSEPTPDPAVRILSPEVRLGSHGRLLLRVNRASLTQGLPEAYRVHRALLLLTPSSRPWDITRPLQRAISLQGPHARALRLRLAPPPDLAVLPSGGARLELHLRSAAGRGRRSAHLHPRDSCPLGPGRCCHLETVQATLEDLGWSDWVLSPRQLQLSMCVGECPHLYRSANTHALIKARLHGLQPDRVPAPCCVPSSYTPVVLMHRTDSGVSLQTYDDLVAQGCHCA
What is the function of this protein?
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.  Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.  It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (Probable).  On hepatocytes, inhibits growth hormone signaling (By similarity).
What are the official names of this protein?
Growth/differentiation factor 15, GDF-15.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRM11_RAT
Sequence: MALPGSLNRYLLLMAQEHLEFRLPEIKSLLSVIGGQFTNSQETYGKSPFWILNIPSEDIARNLMKRTVCAKSLFELWGHGKSPEELYSSLKSYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKVKRIDALEFLPFEGKVNLKKPQHVFSILEDYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHAKVKENDLVFDPFVGTGGLLIASAHFGAYVCGTDIDYNTVHGLGKASRKNQKWRGPDENIRANLRQYGLEKFYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEILKGIEKCPESHVPVSLTYHLSDMFLDLINFAAETLVLGGRLVYWLPVYTPEYTEKMVPWHPCLRLVSNCEQKLSSHTARRLITMEKVKEFENPDEYSRLLSDHFLPYQGHNSFREKYFSGVTKRIATEEQCSHEGKL
What is the function of this protein?
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
What are the official names of this protein?
tRNA (guanine(10)-N2)-methyltransferase homolog, tRNA guanosine-2'-O-methyltransferase TRM11 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
Protein: KCR2_ARATH
Sequence: MQGACISESQPWYLHFVCFIGFLFLLRVLFIPLLKWFTTRFLLTPKRLKRYGSWAMVTGATEGIGRAFAHELAKHGLNLILVSRNLSKLESVSDDFQQEFPHIKIKIIPFDFSSEGGYGAIEEGIKGLEVGILINNVGITYPRAMFFHEVDQLTWTKILRVNLEATTWVTRSLIGPMLHRRRGAIVNISSGAAVVVPSHPLYAIYAATKAYVDALSRSLHVEYKQFGIDVQCQVPLYVSTRMVSEVAAIDKPSLFVPSPEVYAKAAVAQIGIGSRCSPFWAHSLQWFLVGLVPDNLVDTWRLSIGLRRRSLS
What is the function of this protein?
Probable reductase, but unlike KCR1, has no beta-ketoacyl-coenzyme A reductase activity.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470, Beta-ketoacyl reductase 2, AtKCR2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: YDJC_CALS4
Sequence: MKYLIVNGDDFGLTKGVNKGIVESYKNGILRSTSIMCNMPYADEASQIKEICPDLGFGIHITLDAGKPLNSPYKVSTLVDEKGYFKKGFSHSLNEADIDQIKIEIEEQIKKAFSLGVPITHMDSHHGVQSHPKVIEIFIDMAIKYNLPVRATPLDKEVILKSGVKTIDNFVYTFYDEGVEKENLLFILKKLENGITEIMTHPAYVDDELMRVSSYNTKREIERKILTDPDVIQFVKENNITLVNYSIFR
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: PAGE3_HUMAN
Sequence: MSGHQRTRSRSRERRDDQDSNHPVGAVVAQELPSNDQLQQEEPPIESQDYTPGQERDEGALDFQVLGLAAYLWELTRSKTGGERGDGPNVKGEFLPNLEPVKIPEAGEGQPSV
What are the official names of this protein?
P antigen family member 3, PAGE-3, G antigen family D member 1, Prostate-associated gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the GAGE family.