PharMolix/UniProtQA huggingface dataset:
Protein: PUR7_BACC3
Sequence: MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGAIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: TRPB_YERPB
Sequence: MTTLNPYFGEFGGMYVPQILVPALKQLEDAFVSAQLDPEFQAAFQDLLKNYAGRPTALTLCQNLTKGTKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALACALLGLKCRIYMGAKDIERQSPNVFRMRLMGAEVIPVHSGSSTLKDACNEALRDWSGTYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEKEGRLPDAVLACVGGGSNAIGMFADFIDEPDVGLIGVEPAGLGIETGQHGAPLKHGKVGIYFGMKSPMMQTSDGQIEESYSISAGLDFPSVGPQHAYLNSIGRADYVSITDDEALDAFKTLSCKEGIIPALESSHALAHALKMIKADPDKEQILVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PA2B_DABRR
Sequence: NLFQFAEMIVKMTGKNPLSSYSDYGCYCGWGGKGKPQDATDRCCFVHDCCYEKVKSCKPKLSLYSYSFQNGGIVCGDNHSCKRAVCECDRVAATCFRDNLNTYDKKYHNYPPSQCTGTEQC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that has low enzymatic activity, is devoid of lethal activity but has strong anticoagulant activity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 RVV-VD, svPLA2, Phosphatidylcholine 2-acylhydrolase, R1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FIBA_MELME
Sequence: TDVKESEFIAEGAVGR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: ZCHC4_HUMAN
Sequence: MAASRNGFEAVEAEGSAGCRGSSGMEVVLPLDPAVPAPLCPHGPTLLFVKVTQGKEETRRFYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRRCQPPLSRTQCVERYLKFIELPLTQRKFCQTCQQLLLPDDWGQHSEHQVLGNVSITQLRRPSQLLYPLENKKTNAQYLFADRSCQFLVDLLSALGFRRVLCVGTPRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFCHYNMFNHHFFDGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCELCNSCTSKDGRKWNHCFLCKKCVKPSWIHCSICNHCAVPDHSCEGPKHGCFICGELDHKRSTCPNIATSKRANKAVRKQKQRKSNKMKMETTKGQSMNHTSATRRKKRRERAHQYLGS
What is the function of this protein?
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31799605, PubMed:31695039).  N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605).
What are the official names of this protein?
rRNA N6-adenosine-methyltransferase ZCCHC4, Zinc finger CCHC domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the ZCCHC4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Accumulates in the nucleolus, where ribosome biogenesis takes place.
Protein: RS21_CALS8
Sequence: MSEVRVGENESLDSALRRFKKKCAEAGVLAELRKREHYESPSVRRKKKSEAARRRKRR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: APTH1_CRYNB
Sequence: MPTSLKHLKISPKEAHTATVIFLHGLGDSGHGWLPVAKMLWSSFPNVKWILPHAPTIPVSLNHGMAMPSWFDIRHLDKLDNSENDDEQGMLETLKSVDELIQAEVDSGIPENRIVLGGFSQGGAISVLNMLTTKRKLAGVVALSTWVPLNHKIVQMMSEHAKDIPVFWGHGTNDPVVDYRFGQRSVDFLVQKCGYKLLSQGTTFARPGIRFESYPGMPHSSCPQEIEDLKSWLMEALK
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.  Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins.  Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
What are the official names of this protein?
Acyl-protein thioesterase 1, Palmitoyl-protein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ORC6_DROME
Sequence: MTTLIEQLITKMGLREEPNVLEKTTELVRLLELRSTNVPLQINEYGKIVLCADLASCMIGIAFDKEQALKLSGLRKSQYLNNKRMFEKLLDLNKLASVNDICVQLGLNEVARKAEELMTLFKGVAATEDMGTDTSHPQYATMAVFQACRLLKKKVSKSKLMPFSNLRPSQFQLLEQQWERMIAKHHKESKVPSSTDMEGKLKENQNENIKGHEAKKAHKPPPEDYEIWKARMLAKAQAKLKELEASQSHMDSQLLEA
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ORC6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNX17_PONAB
Sequence: MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLREQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPGTDASASDVHGNFAFEGIGDEDL
What is the function of this protein?
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels.  Binds to NPxY sequences in the cytoplasmic tails of target cargos.  Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits.  Also required for maintenance of normal cell surface levels of APP and LRP1.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
What are the official names of this protein?
Sorting nexin-17.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL35_THEYD
Sequence: MPKLKTHRGAAKRFKVTGTGKIMRRRANKSHLLTGKPSKRTRHLRQIAQVDETQYKAIRMLIPYKF
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ORR5_ORYSJ
Sequence: MATCRSRGVERGGAPHVLAVDDSSVDRAVISGILRSSQFRVTAVDSGKRALELLGSEPNVSMIITDYWMPEMTGYELLKKVKESSRLKEIPVVIMSSENVSTRINRCLEEGAEDFLLKPVQPSDVSRLCSRVLR
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ORR5, OsRR5, OsRRA4.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: ANT3_PONAB
Sequence: MYSNVIGTITSGKRKVYLLSLLLIGFWDCVTCHGSPVDICIAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPPEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
What is the function of this protein?
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade.  AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa.  Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
What are the official names of this protein?
Antithrombin-III, ATIII, Serpin C1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: AROK_BORPE
Sequence: MNASANLCAASANDPQPGDQEAAHPVACAGDEPAAFLPHDLPIFLVGMMGAGKTTIGRGLARALRREFIDLDHELEARCGVRVPVIFEIEGEAGFRRREAAALQECTQRRQIILATGGGAVLAAENRQALRERGIVIYLRASVEELFRRTSRDRNRPLLATADPRATLRELMVAREPLYNEVADLVIDTGSMPIATLVKSLLPKLQAYEKK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2656_AZOSB
Sequence: MTELKTLLLFLATAVAEIVGCYLPYRWLREDGSAWLLLPAAASLALFAWLLTLHPAASGRIYAAYGGVYVFVAVLWLWGVDGVRPTVWDITGSLIALCGMAVIMFAPRGA
What are the official names of this protein?
UPF0060 membrane protein azo2656.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTR1A_CAEBR
Sequence: MSERGDDDRTTSTINSLAKRRYQDNLDTFQEERAGFQQKRPHAVDDEDEDFETAAPPTKQKTKAEEMMERMGYKAGEGLGKNKQGIQEPVALSTQRGKTGLGHEGAKAVARDMNEQWDDSTENKTVEETVIWMTDIDEGIRREICDKLIKDDQWMVVRKEKKVIDDETEFCSEKELKDMIEAKNVFDSMSDKDLREARTRANPYETIGSAFFQNRAAMKTANMDKIYDWILSRENTGNNSFLLKNPLQEGTTAENVDRHEDLFYFADVCAGPGGFSEYMLWRKAFYNAKGFGFTLAGKDDFKLQKFTASSAYFFETFYGTKKNGDVMDPENIDSLEKFISEGTDGQGVHLMMADGGFSVEGQENIQEILSKRLYLCQLLVSLCIVREGGNFFCKLFDIFTPFSVGLIYLMRVCYDSISLHKPHTSRPANSERYITCKGLRKEFAGVVKDYLKRVNRKLDELKNKNSKDDVMELMPLDVIKSDEQFMKEIIEHNEVLAHRQTVYLQKYKSFAKNQGQFDKDQGNLRDECLKYWQVPNKQRPRGGDRGSRNGNQERLNPNVVLGKYTSKICGEAELGISFRGLGAASDPQLLIGTGDAVFIYRHGHFEQIDRDYARIPENTILLVDCAEEVKTDGSKIRISSDPHMIRIADAAVLYGDNVSQLPYEARMKAAQKFALALKLTKKTIQIGWGFRAKDITPHQVCCAQTYSLKELDEFQSNLIELKQRGEVIVLFKEGDRQFKTQSLRLTRIIKQDWQMGWSKSQQVPYVHSPLHQKEGSILEDQWKKREIHSSFWDSVILTNKDKQKMTEMMQHGHNAVPSTIWSWKPCMRTEYGPYKIMNHPEAFDGKPTISAIKSQIAETDLSTLRSKYTPLTAL
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs.  Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).  Cap1 modification is linked to higher levels of translation.
What are the official names of this protein?
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1A, Cap1 2'O-ribose methyltransferase 1A, MTr1A.
Protein: HEMG_ECOLI
Sequence: MKTLILFSTRDGQTREIASYLASELKELGIQADVANVHRIEEPQWENYDRVVIGASIRYGHYHSAFQEFVKKHATRLNSMPSAFYSVNLVARKPEKRTPQTNSYARKFLMNSQWRPDRCAVIAGALRYPRYRWYDRFMIKLIMKMSGGETDTRKEVVYTDWEQVANFAREIAHLTDKPTLK
What is the function of this protein?
Anaerobically in vitro transfers electrons to fumarate reductase and nitrate reductase; transfer to nitrate reductase couples this reaction to electron transfer across the cell inner membrane and thus ATP synthesis (PubMed:19583219, PubMed:20484676).  Neither mesoporphyrinogen nor coproporphyrinogen are substrates (PubMed:19583219).  Under aerobic conditions in vitro forms protoporphyrin IX using ubiquinone as an electron acceptor, is able to transfer electrons to cytochrome bd oxidase and cytochrome bo oxidase; transfer to these oxidases couples this reaction to electron transfer across the cell inner membrane and thus ATP synthesis.  In cell free extracts deletion of both cytochrome oxidases prevents formation of protoporphyrin IX (PubMed:20484676).
What are the official names of this protein?
Protoporphyrinogen IX dehydrogenase [quinone], Protoporphyrinogen IX dehydrogenase [menaquinone], Protoporphyrinogen IX dehydrogenase [ubiquinone], Protoporphyrinogen oxidase, PPO.
What is the protein family that this protein belongs to?
Belongs to the HemG family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DEF_STRMK
Sequence: MALLPILEFPDPRLRTKAALIEAAEVTTPAFQELIDNMFLTMYDAPGIGLAATQVDVHKRFMVIDVSEEKNEPHVFINPEIVAKDGGRVYQEGCLSVPGIFADVTRADTITVKYLDRNGQEQQMEAGDVLATCIQHEMDHLDGKLFIDYLSPLKREMVRKKLAKQRKHVA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RRPO_OENBE
Sequence: MLELSLRMCIDYRALTKVTIKNKYPIPRVDDLFDRLAQATWFTKLDLRSGYWQVRIAKGDEPKTTCVTRYGSFEFRVMPFGLTNALATFCNLMNNVLYEYLDHFVVVYLDDLVVYTIYSNSLHEHIKHLRVVRESKEIFESD
What are the official names of this protein?
RNA-directed DNA polymerase homolog, Reverse transcriptase homolog.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBIX_SYNY3
Sequence: MAQPLILGVSGASGLIYAVRAIKHLLAADYTIELVASRASYQVWQAEQNIQMPGEPSAQAEFWRSQAGVEKGGKLICHRWGDVGATIASGSYRCAGMVVLPCSMSTVAKLAVGMSSDLLERAADVQIKEGKPLVVVPRETPLSLIHLRNLTSLAEAGVRIVPAIPAWYHQPQSVEDLVDFVVARALDQLAIDCVPLQRWQGGMEGE
What is the function of this protein?
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD.  The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
What are the official names of this protein?
Flavin prenyltransferase UbiX.
What is the protein family that this protein belongs to?
Belongs to the UbiX/PAD1 family.
Protein: BOYB_DROME
Sequence: MIKISDEKTWQSSRDSVYEVGDSYSGQNANRPLVATNCSEYAVAHANCQLRPVRRFAEVSLLPDILETMRNLGLNRLLRLQSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPIALILVPDLRRVHQVSAMCLALLRKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVATPAQLVWFWQEAPGLMRFPCLQFLVYDDVDLMSREQLQDVQQVLQEILPLSHSPQVVMVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSPEEFRTVIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQVHSWQARSNGVILLCTDNCPELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKPLYSLVLLDDNNHRQLPRLVDFLQLHQKVDHRLVEVAKRIRQELGKARNDQHQLCDQILVLGKCYDPVCESRHRLSHIDRRPDYLPASGDVKVQLVKVYSPTHFCVRLLEHLPPKGTWRMMEYSAVQEFRMQLTQIKEPRRYWPPVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQALDVDTRIFSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPKDHFLQAKILFVAAGTLFVQDLVAIMYADQFKAHVRHLSLARRLVEATLVKRSENAAEMIREFFAEVIIEDDIDENVQDSKEKANSKPHEKMKGKMTDQPAKLQSQPPLSGRCLRLANMAHESVKENQLHQELQERRYETPEIPHQSNESDIPQSNEDRFSQLYECIMNCASLQLEDESKPAKHPDHVLSESVEFHKIMTNEDATPDHTQEKTALLLLPNNVARPSVTYYQTMTTLEFQVFLPEDDHDYKALLLGAQLFFRAISKSSDLILQFIMTLRFPYSSMSHNIRGRTVYISVKKLLALIDPLAFREYRFLKPNHDLFDKVDKQLQETQNRLVRFLEDMNYVKRNFEGQEKRETSEDEEVNVEGIERPDCHKIWDL
What is the function of this protein?
Involved in primary piRNA biogenesis in germline cells.
What are the official names of this protein?
Putative ATP-dependent RNA helicase BoYb, Brother of Yb.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to Yb bodies.
Protein: OXLA_DABRR
Sequence: MNVFFMFSLLFLATLGSCADDKNPLEECFREDDYEEFLEIAKNGLKKTSNPKHIVIVGAGMSGLSAAYVLAGAGHKVTVLEASERPGGRVRTHRNVKEGWYANLGPMRVPEKHRIIREYIRKFGLKLNEFVQETENGWYFIKNIRKRVGEVKKDPGLLKYPVKPSEAGKSAGQLYQESLGKAVEELKRTNCSYILNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDQLPTSMYRAIEESVHFKARVIKIQQNAEKVTVTYQTTQKNLLLETADYVIVCTTSRAARRITFKPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIQGGKSTTDLPSRFIYYPNHNFTTGVGVIIAYGIGDDANFFQALNLNECADIVFNDLSSIHQLPKKDLQTFCYPSIIQKWSLDKYAMGAITTFTPYQFQHFSEALTAPVGRIFFAGEYTANAHGWIDSTIKSGLTAARDVNRASEL
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:21802487).  Is highly active on L-Tyr followed by L-Phe, L-Met, L-Leu, L-Trp, and weakly active on L-Ile, L-Arg, L-Val, L-Lys, and L-Ala (PubMed:21802487).  Inhibits ADP- and collagen-induced platelet aggregation (PubMed:21802487).  This inhibition is inhibited by catalase, indicating the importance of generated H(2)O(2) for the inhibitory effect (PubMed:21802487).  This effect on platelets among snake L-amino-acid oxidases is however controversial, since some of them induce aggregation, whereas the other inhibit agonist-induced aggregation (By similarity).  In vivo, this enzyme induces a rapid, substantial and reversible increase in the paw volume of mice (edema) (PubMed:21802487).  In addition, myofibrosis, and inflammatory cell infiltration on the paw tissue are also observed (PubMed:21802487).
What are the official names of this protein?
L-amino-acid oxidase, DrLAO, LAAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PKFD_EMENI
Sequence: MGSLWSSPSLLPSQQDNETEPFSHLPKEIGTDPTLREDSNVSNRNSEAASTSTDSSTNTNENHASTSQSSLEGAPDSGPIKIAIIGGGIIGIITALGLIHRGINVTVYERAPKYTETSAGFSFSKGARKAMEIVSPRVLEALLRVAAPNKHPFIRYFDGFTPGADEAQWQIPAERPDYYGCLRAAFLESLGQEVPEGIVKFGKVLESYEDNEEGKVLLRFRDGSTAEVDAVIGCDGIKSRTRRIMLGDTHPAAAPGYTEIVAYRAVLPLEGVVAALGEDRGHSHCLAVGPDAYTVSYPIANKPLANMILFRKQRGSWANSDKLLETCHRSTAQDAVKDWKPEIQRLVDLLPENPNKWAIFDTSDNPVPSYVSASGRVCIAGDAAHASTPFLASGAAMGVEDAAVLATVLNTALKEQSYNKTTVVKRKAITAAFQAYSGIRMQRSQRVVKDSRTVGEVCMWQDAETARDPEKCFQAIWQRYTQIWEFDVEEMVERARSECVRLFS
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone (PubMed:23706169).  The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA (PubMed:22510154).  Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable).  Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E (PubMed:23706169).  The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable).  The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase pkfD, Aspernidine A biosynthesis cluster protein pkfD.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: MNMA_STRPS
Sequence: MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYARVVRDEDGTVHMLRGVDNGKDQTYFLSQLSQEQLQKTMFPLGHLEKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQGFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFTEPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_PSEPW
Sequence: MELILLEKVANLGNLGDKVKVKAGYGRNFLLPFGKATVANAANLAAFEERRAELEKAAADRKSSAESRAAQLAELEVTITATAGDEGKLFGSIGTHDIADALTASGVEVAKAEVRLPNGTIRQVGEYDVAVHLHSDVEATVRVVVVAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: DCUP_BACAH
Sequence: MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUAF_ECOLI
Sequence: MYCINTDCTYTKIAIEQLLHEKYFDDRRYCHSIKIYDLRFFKIEDVAYKLIQLFKERRKENIIFLCSDRFIHSKEKPRNIFFLDTKDSIRNWSRHLKKLRYCNSNLLICFLFLCGLYHISVFTGKKQVIIACIKKGFSFAEIVNFLNINARTLVNYLGGLTTYFILPYSDSLYKYIIDNIIASSTEEYHILLTNQRRYYV
What are the official names of this protein?
Uncharacterized membrane protein YuaF.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: END4_MYCLB
Sequence: MLIGSHVSSTDPLAAAEVEGADVVQIFLGNPQSWKAPTLRSDADVLKATALPVYVHAPYLINVASANSRVRIPSRKILQQTCDAAADIGAAAVVVHGGYVADDNDLEDGFQRWRKALDQLQTDVPVYLENTAGGDHAMARRFDTIARLWDVIGETGIGFCLDTCHAWAAGEGLIHVVDRIKAITGRIDLVHCNDSKDEAGSGRDRHANLGSGQIDAELLVAAVKVAGAPVICETAEEGRKDDIAFLREKTSG
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.