PharMolix/UniProtQA huggingface dataset:
Protein: PANB_XYLF2
Sequence: MSIYTNSKPWTVPALAEAKRNGSKIVMLTAYDAGFARILDANGVDLILVGDSLGMVVQGHDSTLPVSVHDMVYHTACVARGVRHAMLVVDLPFQADASPERALEAATALLRVGAQMIKIEGAGHKLEVISYLVEREIPVCSHLGLTPQSVLRFGGYKVQGRGEEAGGRLRAEARAAVEAGATLLLLECVPSQLAAQITTDASVPTIGIGAGAGCDGQVLVLHDLLGLDSGHPRPKFVKDFLAHGGSVAGAVRAYANAVRDGSFPDVEHTYTS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIQK_DANRE
Sequence: MGKKDASSVKLPVDQYRKQIGKQDYKKTKPVLRATRLKAEAKRSAPGIRDIILVIVAVLLFLLGVYAFFYLNLSTELDLDVDMD
What is the function of this protein?
May play a role in cell growth and maintenance of cell morphology.
What are the official names of this protein?
Triple QxxK/R motif-containing protein, Triple repetitive-sequence of QXXK/R protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TRIQK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MURB_STRP6
Sequence: MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISARDMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHRIGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_PSEMY
Sequence: MNLPAALFTPSWPAELELAYARHGERTTPVRRRHLGPLRVQKHLHAEGPEVCQHIIVHPPGGIAGGDRLDISAHAGERTWVQLTSPGAAKWYRAAGVARQDLRLRVEAGATLEWLPQETIVYAGAQAELHTQIELHGDARLFYWDIVALGRPAADERFASGHFQAALDVRRDGRLLWHERQRVSGGDGLLDSPIGLNGQPVFATLLVSGEVDNELLERCREVNIDGVRGDLSQLAGLLVARCLASEALKARAWLIALWRLLRPALLGREAVPPRIWST
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3424_MYCTU
Sequence: MPNPVTMLYGRKADLVILPHVLAEERPHPYSTPGRKRGAQIALTTGIDALASFAPQIVNPRHGLSRVVQCLGGCENKRHAYFRSISKTPHIRARGVPSVCAVRTVGVDGAKRPPKPIPVQ
What are the official names of this protein?
Uncharacterized protein Rv3424c.
Protein: RL35_PARDP
Sequence: MPKMKTKSAAKKRFSMTATGKVKAGPAGKRHGMIKRSTKFIRDVTGTMILSDADAKIVKKYMPYNR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL31B_STAAN
Sequence: MKQGIHPEYHQVIFLDTTTNFKFLSGSTKTSSEMMEWEDGKEYPVIRLDISSDSHPFYTGRQKFAAADGRVERFNKKFGLKSNN
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: GCST_DEIDV
Sequence: MTQTPETALKRTPLHAAHLRAGARMVPFGGWDMPVQYSGLKAEHQAVRESAGVFDVSHMGEFRIQGEGALAFLQHVTPNDVSKLRPGRAQYNWLPNDRGGLVDDIYIYMVGENEYLMVVNASNIDKDWAHLQTLAAGFGVTLTNESDRWALLAVQGPKAAEVLQPHVDVDLGSKKKNAYFPARLFGFNVHLARTGYTGEDGFEVFIDASEAETVWDKLMAIGVTPAGLGARDTLRLEAGFPLYGHEFADDIHPLSSHYTWVVKDKPFYGREALQQPAQQKLIGLKLDKVPVREGYPVLQSGQVVGHVTSGTSSPTLGHPIALALVQAGAADATDFEVEVRGKAHPATRTDVPFYKAP
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: Y820_STAAR
Sequence: MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKKSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein SAR0820.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: TRPB_SYNSC
Sequence: MTSTLPNASTPDPSSLQPAVRPGAHGRFGRFGGQYVPETLMPALAELEQAAAQAWNDPAFTDELNRLLKNYVGRATPLYEAERLTAHYRRADGGPRIWLKREDLNHTGAHKINNALGQALLALRMGKKRIIAETGAGQHGVATATVCARFGLECVIYMGAEDMRRQALNVFRMRLLGATVQPVTAGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEESKQQCQEAFGRLPDVLMACVGGGSNAMGLFHPFVQDMSVRLIGVEAAGDGVASGRHAATITEGRAGVLHGAMSLLLQDGDGQVMEAHSISAGLDYPGVGPEHSYLREIGRAEYAAVTDQQALDALRLVSELEGIIPALETAHAFAWLEQLCPTLADGTEVVINCSGRGDKDVNTVAEKLGDQL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RS21_LACE2
Sequence: MSNVIVKENESLDSALRRFKRNCAKAGIQQEIRKREHYEKPSVRRKKKSEAARKRKFN
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: NU3C_WHEAT
Sequence: MFLLHEYDIFWTFLIIASLIPILAFSISGLLAPVSEGPEKLSSYESGIEPMGGAWVQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEALIFVLILVVGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MZT1_CRYNJ
Sequence: MSSTQDEAILRNARETIDSLYDLSQLLQTGLDKSTLSICVGMIEQGANPDTLAAVIKELRSENEALNSQSNA
What is the function of this protein?
Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
What are the official names of this protein?
Mitotic-spindle organizing protein 1, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1.
What is the protein family that this protein belongs to?
Belongs to the MOZART1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: SYNE3_MOUSE
Sequence: MTQQPQEDFERSVEDAQAWMKVIQEQLQVNDNTKGPRAALEARLRETEKICQLESEGMVKVELVLRAAEALLATCQEGQKPEILARLRDIKSQWEETVTYMTHCHSRIEWVWLHWSEYLLAQDEFYRWFQKMVVALEPPVELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAGSLFSRIGDPSVDEDAQKRMKAEYDAVKARAQRRVDLLAQVAQDHEQYREDVNEFQLWLKAVVEKVHSCLGRNCKLATELRLSTLQDIAKDFPRGEESLKRLEEQAVGVIQNTSPLGAEKISGELEEMRGVLEKLRVLWKEEEGRLRGLLQSRGDCEQQIQQLEAELGDFKKSLQRLAQEGLEPTVKTATEDELVAQWRLFSGTRAALASEEPRVDRLQTQLKKLVTFPDLQSLSDSVVATIQEYQSMKGKNTRLHNATRAELWQRFQRPLNDLQLWKALAQRLLDITASLPDLASIHTFLPQIEAALTESSRLKEQLAMLQLKTDLLGSIFGQERAATLLEQVTSSVRDRDLLHNSLLQRKSKLQSLLVQHKDFGVAFDPLNRKLLDLQARIQAEKGLPRDLPGKQVQLLRLQGLQEEGLDLGTQIEAVRPLAHGNSKHQQKVDQISCDQQALQRSLEDLVDRCQQNVREHCTFSHRLSELQLWITMATQTLESHQGDVRLWDAESQEAGLETLLSEIPEKEVQVSLLQALGQLVMKKSSPEGATMVQEELRKLMESWQALRLLEENMLSLMRNQQLQRTEVDTGKKQVFTNNIPKAGFLINPQDPIPRRQHGANPLEGHDLPEDHPQLLRDFEQWLQAENSKLRRIITMRVATAKDLRTREVKLQELEARIPEGQHLFENLLRLRPARDPSNELEDLRYRWMLYKSKLKDSGHLLTESSPGELTAFQKSRRQKRWSPCSLLQKACRVALPLQLLLLLFLLLLFLLPAGEEERSCALANNFARSFALMLRYNGPPPT
What is the function of this protein?
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton.  The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.  Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.  Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells (By similarity).
What are the official names of this protein?
Nesprin-3, KASH domain-containing protein 3, KASH3, Nuclear envelope spectrin repeat protein 3.
What is the protein family that this protein belongs to?
Belongs to the nesprin family.
What are the subcellular locations of this protein?
Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum.
Protein: I23O2_RAT
Sequence: MEAQRQDGKLASSLSLGKYHISEEYGFLLPNPLEELPDHYKPWMEIAHRLPHLIESHQLQAHVYEMPLLDCRFLTSYREQRLAHLVLAAITMGFVWQEGEAQPQKVLPRTLAIPFVEVSRSLGLPPILVHSDLVLTNWTKRNPEGPLEIGNLETIISFPGGESLQGFILVTVLVEKAAVPGIKALVLGVEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPEIFYLVIRIFLSGWKDNPVMPVGLVYEGVSTEPLKYSGGSAAQSSVLHAFDEFLGIQHCKESVDFLHRMRDYMPPSHKAFLEDLHSAPSLRDYILDSGPGGCLMAYNQCVEALGELRSYHINMVARYIISAASKARSRMLTRLSPHALEDRGTGGTAVLSFLKSVREKTMEAILCPGA
What is the function of this protein?
Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.  Involved in immune regulation.
What are the official names of this protein?
Indoleamine 2,3-dioxygenase 2, IDO-2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
Protein: DAPB_AQUAE
Sequence: MSVRVVVCGALGRMGRRIIELALQDKDVEVVGGVEHPDCVPSIDLGEALGKEELKGKPLTSRLEELLPYTDVVIEFSGNPTAAVGHAELTTLEKKAIVIGTTGFTKQEIEQIKEFSKNAPVLLSPNMSLGVNLLFKLAEIAAKVLKDKNFDAEIMEIHHRFKKDAPSGTAMKLAEILSETLEKKNLVFGRKGEAPRKEDEIGVMALRGGDVVGDHTVYFLGFGERIELTHRATSRDTFAKGAVEAAKWIKGKEPGFYTMFDVLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROK1_PICST
Sequence: MDIFRILSRGASLKKSKDVTTDYALPSAKQQQYEQHKEDTLQHQVDKEIDFFHTKKHNSSKSFDSTDSKHTKEEKKEKKEDEEAPPLEIQTVEDSIKLRKANHSKVTGEDIPLPIGSFQDMIGRFRLDSKLLSNLLEAEFVEPTAIQCESLPISLSGRDLIACAPTGSGKTLAFLIPLIQSLLVSSKGRPKNYGITGLVISPTNELAIQIFQELQILTRGKKLNVAILSKQLANKLNNDIVKASKYDIIVSTPLRLIDIVKNEKVDLSKVEQLVIDEADKLFDQGFVEQTDDILSHCTYTKIRKSMFSATIPSGVEEMAHSIMRDPIRVIIGRKEAASNTIDQKLVFTGSEEGKLLAIRQMIQEGEFKPPIIIFLQSIHRAKALFHELLYDKLNVDVIHAERTPKQREEVIKRFKNGDIWVLITTDVLARGVDFKGVNMVINYDVPQTAQAYVHRIGRTGRGGKAGRAVTFFTKEDDQAVKPIINVMKQSGCEAGFSGWMENMTKMSKNEKKKVKHKEIDRKDISTVPKLVKHKRKQREQMIEASKKRKQEETRNALQ
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase ROK1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CYSD_SHESA
Sequence: MAGRELSHLQQLEAESIQIIREVAAEFDNPVMLYSIGKDSSVMLHLARKAFYPGKIPFPLLHVDTGWKFKEMIAFRDAQAKKFGFELLTHTNPEGVAQGINPFDHGSAKHTDIMKTQGLKQALNQYGFDAAFGGARRDEEKSRAKERVYSFRDRHHRWDPKNQRPELWRTYNGAVNKGESIRVFPLSNWTELDIWQYIYQENIELVPLYFAAERPVVERGGQLIMADDERMKLEEGETIKHEVVRFRTLGCYPLTAAMHSQADNLEKIIEEMLLTRSSERQGRLIDSDQSASMEQKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: SYE1_CALS8
Sequence: MEVRTRFAPSPTGHLHIGGARTALFNYLFAKRYGGKFILRIEDTDLERSSIESEKVIIESLRWLGIEWDEGVEVGGPYGPYRSTERVDIYKKYVDVLFEKGYAYYCYCTEEELEAQRQELLSKGQMPRYLGKCRNLTEDQKRRFEQEGRKPTVRFKVPEGVKIVVHDLVRGDVEFLSDDIGDFVIVKSDGIPTYNFAVVIDDHLMKISHVIRGEEHLSNTPRQILIYNALGFELPQFAHVSLILGKDRTKMSKRHGSTWVEQYRDQGYLKEGLINFLALLGWSPPEDREIFDMEYLIENFSLERVSKNPAIFDIDKLNYINSQHIKLKSLDELTQMCIPYFVEAGYIKEDEAKSKFEWLKKIVKSVYEGLDYLSQIKDRVDIFFNNEVKIEEDEAKEVLKWDHVKDLINVFENKIRQMNELTPEAIKLLFKEIQKETGYKGKNLFMPIRVALTGKTHGPELVEIIEIVGKENILKRLEFFKTWYN
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_SHISO
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQLEGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_STRU0
Sequence: MFVKKGDKVRVIAGKDKGTEAVVLKALPKVNKVVVEGVGMIKKHQKPNAENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKVVDGKKVRYSKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MMM1_COCIM
Sequence: MSNDTSAQPAQSSLSFTQGLLVGQLSVVLLIGAFIKFFIFGEASPSSSRSQTRRTSPHKRSYSISGARDLGSRSLKEKPSSNVLRPVPSSSTNTRSILRKTYYSANPTNFTSKHGRHRPHHSTHQPESLDWFNVLIAQTIAQYRQTAYILKDSPTSSILESLATTLNNPEKKPSFIDDITVTDISLGEEFPIFSNCRVIAIDDPSSDGGRLQALMDVDLSDDNLSLAIETNLVLNYPKPYSAILPVALSVSVVRFSGTLCISFVPGTTQTSTHLATSPSNIDPTLQTNDYSGANRRGNRRQERTDTEQATQANNAGTTGIPKTSLAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQAWFEERVVEPRVQVVALPGIWPRMGRTGVRGQEEQQEVGSSGNAGVSTANVSMLGARDAGAEGSHATRDADMEGLRYRRNASPGDETSGVRYSPQNQDSREQACRDDPFRIPGSLPDVVPVT
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RS3_KARMG
Sequence: MGHKVNTLSNRLGLIVGWQSLWYSHYPERIKEDFKIRKYLENRLSKANISRIYIERSLNRVIITISSSRPSIIIGKGGSEIDKLKKELNIFIYKKIQINIFEIKKPELDAVLVSKSIASQLENRGSYKKAIKICISAALQVNAEGIKIKISGRLNGAEMARKETYKEGRIPLSTFRADIDYHMTEAHTNYGIIGIKVWIMKGEIYGKKNLFNIFKLKYKKKKVYSD
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HTPX_HELPS
Sequence: MTNFEKIIAQNKLKTNAVLATYCVIFAFIGLLVDVIRINANDLGTALFKLMTFQIFPTITIIMFLVAFVIIVVCIQNFSSIMLSGDEYKLIDKSKVLSSKENQIHRLLLELLEEAKLHFEPKLYIIKAPYMNAFASGWNESNSLIALTSALIERLDRDELKAVIAHELSHIRHNDIRLTMCVGILSNIMLLVANFSVYFFMGNRKNSGANLARMILLVLQIILPFLTLLLQMYLSRTREYMADSGAAFLMHDNKPMIRALQKISNDYANNDYKGVDQNSTRSAAYLFSAEMFSTHPSIKNRIQSLSRRVI
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NONA_DROME
Sequence: MESAGKQDNNATQQLPQRQQRGNQQANKNLGKHNAQKQNDSADGGPAEKKQRFGGPNAQNQNQNQNQNGGVTGGGGAVGGPNQNKNFGNNKGGFVGNRNRNNNRAGNQNRTFPGNNNPNQKPNNETSKADGPNALAKNNEPATAAAGQNQANQNANKGQNQRQGQNQNQNQVHGQGNQGGPGNQGGAGNQGGQGNQGGAGNQGNGQGFRGRNAGNNQGGGFSGGPQNQQRDNRNRSGPRPGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTFELEPVEVPTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKHMGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDFNQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELLRQELRKREVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEEDMLRRQQETLFMKAQQLNSLLDQQEGFGGGGGGNNSTFDNFAGNSNSPFEVFRGNNNNNSTMIGNNAAPNTQDSFAFEFGVNNMNQGGNQRGNNGGGNNVPWGRRRF
What is the function of this protein?
Required for normal vision and courtship behavior in Drosophila.
What are the official names of this protein?
Protein no-on-transient A, Puff-specific protein Bj6.
Protein: PID3_CAEEL
Sequence: MVAHQKADFKSKWAMVVTVNNLNDKKRADLREFSEWFIETLRLEGAFIGHYFNYEAAPVTIVETLPGNFDSCTNAYQKIHKEHPQVVLVVHILPQSQSNEYEWMKVLASRYGFVRQGLLYDNCANRFQNVETDQNSVFRNMCQWIYRSGTAIVRNEGNACGILHGKDPKPTFDKVLFNSEDIKDSVFKVLHAEEEPRGADQENMLKISGYPGMLNTFGIAQLLTPYRVNGITITGAQSAVVALENKFQVYQAVQDFNGKKLDRNHKLQVSSLVVSSPAVPLEWPSLKKSKKLVEQVGKPIRLSKVSS
What is the function of this protein?
Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475).  Within the pid-1 variant of the PETISCO complex may stabilize 21U-RNA precursor molecules (PubMed:31147388).  Promotes the biogenesis of 21U-RNAs (PubMed:31216475).  Required for chromosome segregation and cell division in early embryos (PubMed:31216475).
What are the official names of this protein?
Protein pid-3, piRNA biogenesis and chromosome segregation protein 1, piRNA-induced silencing defective protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Dispersedly distributes throughout the cytoplasm in early embryos (PubMed:31147388). During early embryogenesis, localizes to the nucleus at prophase of cell division, and remains in the cytosol at interphase in 2- and 4-cell embryos (PubMed:31216475). Localizes to puncta in the perinuclear region in the germline syncytium (PubMed:31147388).
Protein: TRM56_ARCFU
Sequence: MEVYVLRLGHRPERDKRISTHVALTARAFGAKGIYFDTEDKSVFESVRDVVERWGGDFFIKAVSWKKLLREFDGLKVHLTMYGIPLPQKLEEIKRADKVLVVVGAEKVPPEVYELCDLNISIGTQPHSEVAALAVFLDRVLGKVFDISFDDAKIKVIPSERGKRVVSE
What is the function of this protein?
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
What are the official names of this protein?
tRNA (cytidine(56)-2'-O)-methyltransferase, tRNA ribose 2'-O-methyltransferase aTrm56.
What is the protein family that this protein belongs to?
Belongs to the aTrm56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_XANC8
Sequence: MSKKPAKDKAKSATATKTIALNKRARHEYHLEERYEAGLALQGWEVKAIRAGRANIVDGYAYVRSGEIYLIGAQITPLIQASTHVIPVERRDRKLLLHRAEIDKVLTRVEREGYTLVPTALYWSSNKVKLEIALAKGKQSHDKRDAAKERDWQRDKQRVMRRHNRDA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GPDA_CLOAB
Sequence: MGGVTFIGGGSFGTALAIMLAKKGHNVVIWDRNKEILEDINTLRTNTRYLPNNIIPCCVKAVDDIEKAAKESKYIVLAVPSFAIREVCRKIKGFLREDQIIISIAKGMEEETKKRLSEVVKEELYKNPVVVLSGPSHAEEVANDIPTTVVVTSTDMKYAEEVQDVFMTNSFRVYTNSDIVGVEIGGAVKNIIALASGIGDGIGYGDNTKAALMTRGMSEIMRIGVKLGGKPETFFGLTGMGDLIVTCTSMHSRNRKAGILIGRGMSCREACDKIGMVVEGVKACHTFYELKESLGVSMPITTSLYKVLFENGDPKKEVYELMARDKKNEYYF
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.