PharMolix/UniProtQA huggingface dataset:
Protein: ATPH_FAGEA
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MURI_SPHAL
Sequence: MHPPAPDAPILFFDSGLGGLSVLGPTRALLPTAPIVYAADYAGLPYGRKSNEELAARVPALLGRLVERYQPRLAVIACNTASTIALGHVRAALDLPIVGTVPAIKPAAEMTKSGVIGVLGTEATVRQPYVDDLSARFAGGKTVLRHGSPGLVTGAEARLRGETVDPEVIARAVAGLRDQPRGDAIDVVVLACTHFPLLKDELQAGFGRGVALIDGAEGIARRIAHLTDGQAWPAIAVPGIAVFTRSDERPPPPLAVLAPYGIGSIETV
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: SC61B_DICDI
Sequence: MKRPSTQRAPATVNKGGNSMMKFYSEDAIGLKVGPTAVLFMSLIFIAFVIILHIMGKYTRS
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides.
What are the official names of this protein?
Protein transport protein Sec61 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: COF_YERE8
Sequence: MYRLAAFDMDGTLLMRDHRIGGATLNALHQLVDNGMILTFATGRHYLDMKGILSHSGINGYLITGNGTRVCDMDGMHLDGMDLPAELVEFVLRTPWQTNASIHIFRDDGWFTDYNDPALLAAHKTSSFQFQLTALDALPKTGNHKICFIAPHQELAELKIQLEQHMGDQADFCFSAVDCLEMLPRGCNKGAALERLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQVIGRCEEQGVAHYLQHWLSSPHLTYSPEF
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: TOP3_BACC1
Sequence: MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGRAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVMEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSKFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: TXND5_MOUSE
Sequence: MPPRPGRLLQPLAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL
What is the function of this protein?
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins (PubMed:12930873, PubMed:14971039).  Can reduce insulin disulfide bonds (PubMed:14971039).
What are the official names of this protein?
Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, ER protein 46, ERp46, Plasma cell-specific thioredoxin-related protein, PC-TRP, Thioredoxin-like protein p46.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: YCF3_NEOYE
Sequence: MPRSQKNDNFIDKTFTVLADIVLKILPTSKEEKEAFSYYRDGMSAQSEGEYAEALENYYEALKLEEDPYDRSYILYNIGLIYASNGEYVKALEYYHQGLELNFKLPQALNNIAVIYHYQGVQAIEDKDTELSKLMFDKAAQYWQQAIKLAPDNYIEAQNWLKTTGRMRNIQGY
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL9_EHRCJ
Sequence: MLSIILKESVRNLGKAGVVTKVKPGYARYLLTQKKAVRATKENLKNLEEQYLVIERENLEKLEAAKALKLSLEDEFLIITRQAADDGKLFGSVTPKCISKLLSDKGYNIHYRNIFFYSVIKYIGEYVVNLELHPDLVLPITLYVVKNDLGAMQAQKLHAEKKRKIEKEVEEGSGTSVDESLKLDSVSDSIDTSGVNSSDKEEENNIIE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HDFR_ECO24
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: YKOH_BACSU
Sequence: MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLADETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLSFHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAASAAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTFNEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIHSEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKESLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIPHLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQNGGGR
What is the function of this protein?
Probable member of the two-component regulatory system YkoH/YkoG.  Potentially phosphorylates YkoG.
What are the official names of this protein?
Sensor histidine kinase YkoH.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABH_STRPM
Sequence: MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVADQLLTQSGLKADAIDFIIVATISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALAMADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDGAGGVLLEASKDKHVLAETLHTDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITKDDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRLDGTQKILLSGFGGGLTWGSLIVKI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMID_RHOER
Sequence: MATIRPDDKAIDAAARHYGITLDKTARLEWPALIDGALGSYDVVDQLYADEATPPTTSREHAVPSASENPLSAWYVTTSIPPTSDGVLTGRRVAIKDNVTVAGVPMMNGSRTVEGFTPSRDATVVTRLLAAGATVAGKAVCEDLCFSGSSFTPASGPVRNPWDRQREAGGSSGGSAALVANGDVDFAIGGDQGGSIRIPAAFCGVVGHKPTFGLVPYTGAFPIERTIDHLGPITRTVHDAALMLSVIAGRDGNDPRQADSVEAGDYLSTLDSDVDGLRIGIVREGFGHAVSQPEVDDAVRAAAHSLTEIGCTVEEVNIPWHLHAFHIWNVIATDGGAYQMLDGNGYGMNAEGLYDPELMAHFASRRIQHADALSETVKLVALTGHHGITTLGGASYGKARNLVPLARAAYDTALRQFDVLVMPTLPYVASELPAKDVDRATFITKALGMIANTAPFDVTGHPSLSVPAGLVNGLPVGMMITGRHFDDATVLRVGRAFEKLRGAFPTPAERASNSAPQLSPA
What is the function of this protein?
Hydrolyzes propionamides efficiently, and also at a lower efficiency, acetamide, acrylamide and indoleacetamide.  This enzyme seems to be stereospecific and can lead to the production of a single enantiomer.
What are the official names of this protein?
Amidase.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
Protein: HSP7E_MOUSE
Sequence: MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSEREQVVGLAAKQSRIRHVSSTVVKVKQILGRSSADPQAQKYISESKCLVIEKNGKLRYEIDTGEETKLVNPEDVARLIFSKMKETAHSVLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDHPTGKSNVLVFKLGGTSLSLSVMEVNSGMYRVLSTNTSDNIGGAHFTDTLAQYLASEFQRLFKHDVRGNARAMMKLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCTEAIRELLRQTGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDDSVMIECSAKDILVKGVDESGADRFTVLFPSGTPLPARRQHTLQAPGRVSSVCLELYESEGKNSAKEEAKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQDTGKCEAITVEVAS
What is the function of this protein?
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.  In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).
What are the official names of this protein?
Heat shock 70 kDa protein 14, NST-1, hsr.1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TRPD_PSEPF
Sequence: MNIKTALSRIVDHLDLSTDEMRDVMREIMTGQCTDAQIGAFMMAMRMKSESIDEIVGAVSVMRELADKVELKTLDRVVDVVGTGGDGANIFNVSTASSFVVAAAGCTVAKHGNRAVSGKSGSADLLEAAGIYLNLTPVQVARCIDNVGIGFMFAQTHHKAMKYAAGPRRDLGLRTLFNMLGPLTNPAGVKHQVVGVFTPALCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAELKDDQITEYWVEPEDLGMKSQSLHGLSVEGPEASLALIRDALGKRKTENGQKAAEMIVLNAGAALYAADLATSLKEGVALAHDALHTGLAREKLEELGAFTAVFKVENEG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: NVD_DROME
Sequence: MTSYSLFWMSLLKNNWKPISNDFVICLWTLAVTFIRIYWIFFVPLEWKKDLDNEKWSFLRKTENVVCYNHKRDTINRLRKLKIQKIIELPPPYPNGWYGILKSSQLKAGEATCVSCLGEDLVIFRSKKDIVFILDAYCPHLGANLGIGGSVADDCVICPFHQWKFRGTDGLCINIPYSTSVPKGSKLKKWISQEVDGFIFIWYHAEQTELPWDLPVPMGEIDDTFVYHGHNEFYINCHIQEIPENGADIAHFNAIHKKNFINGSWAQKKRLFGLGSHHWKARWSPFTGKLKYLAEVNLSHTFKLFGKFGCFRMEVSGKQIGPSIVCLEVNSYTFGKIKVFQYITPIEPMLQKVVHEFYGPRWIAPLMKIFIYGESLMFERDIKIWNHKVFNRNPILAKEDASIKKFRLWFSQFYSSNSKIYSEATNIGW
What is the function of this protein?
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol (PubMed:21632547).  Essential regulator of steroid biosynthesis, as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid (PubMed:21632547, PubMed:16763204).  Required for insect molting, metamorphosis and body growth throughout development via the regulation of ecdysteroid biosynthesis in the prothoracic gland (PubMed:16763204).
What are the official names of this protein?
Cholesterol 7-desaturase nvd, Neverland, Nvd_Dm, Rieske-domain protein Neverland.
What is the protein family that this protein belongs to?
Belongs to the cholesterol 7-desaturase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TDH_PARPJ
Sequence: MKALAKLERAPGLTLTDVKKPEVGHNDVMIRITRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLVIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAVAIAKHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSMLEAMNHGGKIALLGIPPAQTAIDWTQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPILTHHFKVDDYQEAFATMLSGESGKVILDWTAA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN_PYRAB
Sequence: MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: SCPB_STRA5
Sequence: MTYLGSIEALLFVAGEDGLSLRQMAELLSLTPSALIQQLEKLAKRYEEDDDSSLLLLETAQTYKLVTKDSYMTLLRDYAKAPINQSLSRASLEVLSIIAYKQPITRIEIDDIRGVNSSGAITRLIAFGLIKEAGKKEVLGRPNLYETTNYFLDYMGINQLDDLIDASSIELVDEEVSLFSMDSINTEDKENNEN
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: RS3_DROME
Sequence: MNANLPISKKRKFVSDGIFKAELNEFLTRELAEDGYSGVEVRVTPSRTEIIIMATKTQQVLGEKGRRIRELTAMVQKRFNFETGRIELYAEKVAARGLCAIAQAESLRYKLTGGLAVRRACYGVLRYIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPCNDYVETATRHVLLRQGVLGIKVKVMLPYDPKNKIGPKKPLPDNVSVVEPKEEKIYETPETEYKIPPPSKPLDDLSEAKVL
What is the function of this protein?
Has DNA repair activity directed towards the mutagenic lesions 8-oxoguanine and abasic sites in DNA.  It can cleave DNA containing 8-oxoguanine residues efficiently.  Also acts as an ap lyase, cleaving phosphodiester bonds via a beta,delta elimination reaction.
What are the official names of this protein?
40S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PBP2_NEIGO
Sequence: MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAMAVLFACLIARGLYLQTVTYNFLKEQGDNRIVRTQALPATRGTVSDRNGAVLALSAPTESLFAVPKDMKEMPSAAQLERLSELVDVPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVVLRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPLSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS
What is the function of this protein?
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
What are the official names of this protein?
Probable peptidoglycan D,D-transpeptidase PenA, Penicillin-binding protein 2, PBP-2.
What is the protein family that this protein belongs to?
Belongs to the transpeptidase family. FtsI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YHYA_PSESN
Sequence: DQEIVVKSMAMEKVYELACRVADSDATIFLQGETGVGKEVLARTIHNSSIRKEAPFIKVNCGAIPESIMESELFGYSKGTFTGGNKDGKKGLAQAAHNGTLFLDEIGELPLNLQAKLLQLLNEKQFTPLGEIKPVQVDVRFIAATNRNLEDMVREGTFREDLYYRLFVIPITIPSLSERREDIPFLINHFLETFNHKYKLYKTIDKEVVQFFIDYEWKGNVRELQNTIERLVLISSAQQIELSDLSDKFKKATSHTKGGISGEGLNLKQKMEQFEKQILIQTLESSNTMKEASKN
What are the official names of this protein?
Uncharacterized protein in HyuA 5'region, ORF1.
Protein: TRUA2_PARUW
Sequence: MDYTTQSDLSLSKSMQNIKLKIAYDGQAYFGWQKTPAGPSVEKTLQNSLEQILQHTISLQAASRTDKGVHARGQIVNFLTTKSITDLQKFILSLNSLLPTDLRILSAEKMPSTFHPTLNCVAKEYCYYICYDFVQLPEYRPYSWHCPFPLMLGKMTQAISVLIGEHDFSAFCNFKKNVNYTDYIRRVQAIHLEVLNHKRLCIRIKGNHFLYKMVRNIVGTLIYIGKGKLMVEDIPSILQSQDRKMAGVTAPAHGLFLQTVLY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A 2, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I 2, tRNA-uridine isomerase I 2.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ILVC_ACIBY
Sequence: MQIFYDKDCDLSIIQSKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRAGSASWKKAENAGLKVAEVPAAVKQADLVMILTPDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRKDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNARNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYAPEMAYFECLHELKLIVDLMFEGGIADMNYSVSNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEQTGAKLRAMMPWIQANKIVDKEKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GREA_BUCAI
Sequence: MINLIPMTVRGAEKLRRELKKLKSINRPRIIAAIAEAREHGDLKENAEYHSAREEQSFCEGRIKEIELKLSNSQIIDVTKISNNGRVIFGSTVSILNIKNNEKFTYRIVGDDESDFKKNLISINSPIARGLIGKEINDVVIICTPGGDVEYKILKINYI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: C99L2_RAT
Sequence: MVARLTTLLVCLVFSLATLVQRGYGDFDDFNLEDALKETSSVKQSHFSTTTRRTGTTRAPANPAERWDHMTTTTTKRPGTTRAPSNPLELDGFDLEDALDDRNDLDGPKKPSTGEGGGLSDKDLEDILGGGGYKPDKNKGGGGGYGSQDDPGSGAVTDPGTIAGLVSALAAALLGAVSGYLSYQHRKFCFSVQRGLDAAYVKGENLEAVVCEEPRVEAAMCEAPPVTDSTQHSQPTEPLAPERPRI
What is the function of this protein?
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane.  Acts at the same site as, but independently of, PECAM1 (By similarity).  Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).
What are the official names of this protein?
CD99 antigen-like protein 2, MIC2-like protein 1, Rhombencephalic expression protein 40 kDa, Protein rhombex-40.
What is the protein family that this protein belongs to?
Belongs to the CD99 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction.