PharMolix/UniProtQA huggingface dataset:
Protein: ZWILC_CAEEL
Sequence: MPLTIEQLKQYNEKMAAKGEEDDAPAPVLLLDKYRVRVLPLTSIPFVMNHSSVSQLSLSSEDVLVVDFPSKGTGSGAGKAEKKMIFKKKIEPMEDSFEDKENVNEGGPLMTSFLTLEKLRKGMVGDVEIIGYECETSFFDANPIPLSDGVSLQRYIRLNCSEHFSPSISTLPVWISTTSSKFPSICWLAAGRTNRNVQFAAATRVLGHFNNENSERVVKQLNQACGTSQLNKYRAVYEEIRKIATENRPAPGEVTIDVRWSTKSTLVLLEHPDNAADCTIKIDLGWGDKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPANFDDLVQEMDALVEASSREDNVFVSNENFRGGDITDKVWNIVRKCNDVKQVTLLFRNFLQALAYGKIKSHAQERNKSHLASLIRISKSSEFKIPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILQTCENDLPAGNGAMNSAAISLLPITMALATANRIYELLNEKDHVILPDLTRRILQKYTASMIEKSRRGETETEYTFETTLPLLRMYKEGFMSKRPCIWTCENSNTVGANVQARVLTSLELQPSLEHINRLVNDSRPVWTATEEKPAMIKDLNADYTVVHTIFSYLPKM
What is the function of this protein?
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:18765790).  Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790).  Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790).  The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790).  To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804).  The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804).  Required for embryonic development (PubMed:18765790, PubMed:19109417).
What are the official names of this protein?
Protein zwilch homolog.
What is the protein family that this protein belongs to?
Belongs to the ZWILCH family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition (PubMed:18765790). Localizes to kinetochores, spindle- associated rod-shaped structures and near the cell cortex in a knl-1- dependent manner in anaphase (PubMed:18765790, PubMed:20729837).
Protein: NBP35_YEAST
Sequence: MTEILPHVNDEVLPAEYELNQPEPEHCPGPESDMAGKSDACGGCANKEICESLPKGPDPDIPLITDNLSGIEHKILVLSGKGGVGKSTFAAMLSWALSADEDLQVGAMDLDICGPSLPHMLGCIKETVHESNSGWTPVYVTDNLATMSIQYMLPEDDSAIIWRGSKKNLLIKKFLKDVDWDKLDYLVIDTPPGTSDEHISINKYMRESGIDGALVVTTPQEVALLDVRKEIDFCKKAGINILGLVENMSGFVCPNCKGESQIFKATTGGGEALCKELGIKFLGSVPLDPRIGKSCDMGESFLDNYPDSPASSAVLNVVEALRDAVGDV
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NBP35, Nucleotide-binding protein 35.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATP4_IPOBA
Sequence: MFRHSSRLLARATTMGWRRPFSTDLPAETAADSTFVEAWKKLIPNVDPPKTPSAYMAPRPATPSSIPSKLTVNFVLPYSSELAGKEVDMVIIPATTGQMGVLPGHVATIAELKPGVMSVHEGNDVSKYFVSGGFAFIHANSFADIIAVEAVPLDRIDANLVQKGLAEFTQKLNTASTDVEKAEAQIGVDVHSALNAALTG
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element.  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit delta', mitochondrial, F-ATPase delta' subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: NANK_ECO55
Sequence: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEYQALEGDITDMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADARTIFTRAGQGDEQAQQLIHLSARTLARLIADIKATTDCQCVVVGGSVGLAEGYLALVEMYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: SUCC_ANAD2
Sequence: MKIHEYQAKEILRKFGVAVPRGYLAVTPLEAEGAARQLGGGISAVKAQIHAGGRGKGGGVKLARSPDEARQHAEAMLGMMLKTPQTGPDGQEVRKVYVEEGCRIARELYLGMTLDREIGRLAVMASVEGGVDIEEVAAKHPDKILREWISPLTGLMPFQARRLAFGLGLTGDSVTAFVRFATGLYNAYVATDASLAEINPLVITVGGEVLALDAKMNFDDNALYRHPDIAAMRDPDEEDPKETQAKEYDLSYIALDGDIGCMVNGAGLAMATMDVIKLSGGQPANFLDVGGGADEDKVTAAFKIILSDPHVKAVLVNIFGGIMKCDVIANGIVAAAKQVGLSIPLVVRLEGTNVELGKDILAHSELKIIPADDLGDAARKVVQAARAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: NRAM_I76AI
Sequence: MNTNQRIITIGTICLIVGIISLLLQIGNIILLWMSHSIQTGEKSHPKVCNQSVITYENNTWVNQTYVNISNTNIAAGQGVTPIILAGNSSLCPISGWAIYSKDNSIRIGSKGDIFVMREPFISCSHLECRTFFLTQGALLNDRHSNGTVKDRSPYRTLMSCPIGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNKILRTQESECVCINGSCFTIMTDGPSNGQASYKLFKMEKGKIIRSIELDAPNYHYEECSCYPDTGKVVCVCRDNWHASNRPWVSFDQNLDYQIGYICSGVFGDNPRSNDGKGNCGPVLSNGANGVKGFSFRYGNGVWIGRTKSISSRSGFEMIWDPNGWTETDSSFSMKQDIIALTDWSGYSGSFVQHPELTGMNCIRPCFWVELIRGQPKESTIWTSGSSISFCGVNSGTASWSWPDGADLPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: VM2_CROAD
Sequence: MIQVLLVTICLAVFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAVQLKYEDAMQYEFKVNGEPVVLHLEKNKGLFSEDYSETHYSPDGREITTYPPVEDHCYYHGRIQNDADSTASISACNGLKGHFKLQGEMYLIEPLKLSDSEAHAVYKYENVEKEDEASKMCGVTETNWESYEPIKKASQSNIPPEEEAFYQRYIELVVVADHRMYTKYDGDKTEISSIIYEIVNTLTQIFRPLHIRVALIGLEIWSSGELSKVTLSADDTLEAFGEWRKTVLMNRKRHDNAQLLTGMIFNETIEGRTYKSGMCNPKHSVGIVRDYRTRRHFVANRMAHELGHNLGIDHDRDSCTCGANSCIMSATVSNEPSSQFSDCSLNKYLNYIVRYQSTTRCLHNEPSETDIVSPPFCGNYFKEVGEDCDCGPPANCQNPCCDAATCKLTTGSQCAEGLCCDQCKFTKKGTACRPARGDWNDDTCTGQSADCPRNGLYG
What is the function of this protein?
Recombinant disintegrin r-Cam-dis (413-488): this recombinant protein inhibits platelet adhesion to fibrinogen (IC(50) is 1 nM), inhibits collagen- (IC(50) is 18 nM) and ADP-induced (IC(50) is 6 nM) platelet aggregation, and also inhibits platelet function on clot retraction.  May act by binding integrin alpha-IIb/beta-3 (ITGA2B/ITGB3).
What are the official names of this protein?
Zinc metalloproteinase-disintegrin VMP-II, CamVMP-II, Disintegrin r-Cam-dis, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIb sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: A3LT2_RAT
Sequence: MALEGLRAKKRLLWRLFLSAFGLLGLYHYWFKIFRLFEVFIPMGICPMAIMPLLKDNFTGVLRHWARPEVLTCTSWGAPIIWDETFDPHVAEREARRQNLTIGLTVFAVGRYLEKYLEHFLVSAEQYFMVGQNVVYYVFTDRPEAVPHVALGQGRLLRVKPVRREKRWQDVSMARMLTLHEALGGQLGREADYVFCLDVDQYFSGNFGPEVLADLVAQLHAWHFRWPRWMLPYERDKRSAAALSLSEGDFYYHAAVFGGSVAALLKLTAHCATGQQLDREHGIEARWHDESHLNKFFWLSKPTKLLSPEFCWAEEIGWRPEIHHPRLIWAPKEYALVRT
What is the function of this protein?
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide.  Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures.  Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids.  Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids.
What are the official names of this protein?
Alpha-1,3-galactosyltransferase 2, Isoglobotriaosylceramide synthase, iGb3 synthase, iGb3S.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma.
Protein: SHKD_DICDI
Sequence: MKRFFSNLFKRKQDQNSHIKQINGPTTSTPTTTPTTPTTPTTTQTPTPQNNNTNNNTNNNNNTNSNNSNQQKKEQAQASPSTNQTQTPSNNTISTSPTVTTQPSFTPGVISTSKLTTSPPESPRPPTSTTNTTQPSTTTTTATNSTNTNTASAPTKTASPSSPSATASPNNNSNNTTTTAATTTTTTTTTTTTNANQTASVNHTSSDQSLNAQNVTQTNNNNNNNNNNNNNNNANNTKPINPNDYIPLDFVDSTPKVDNNQPKRKASGPPEILPEEIDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPNVVLFLGACTQSGKMQIVTELCQTDLEKLLHNDRTKKEFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNEKADVYSFGIILWEILTKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRLNEILIDCAIDFDDGRKYWKEHFLVPKQELQEEVEWSDFEKTLKATHKQLNLDYAPLKELLVQQSHQTVQKTKQVVTMERFDKVSKWFGSFFEPNTGIETIDNINKLSAKIWFHGDIVREQATSRLSKAAEGAFLIRLSSTEPKTCPFTLSMKNNQHRRIQLIDENNFTGFKIQGKTAVYNSLIELVEKCNDYPLLVPCPKFTQETFNPYDPYTN
What is the function of this protein?
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells.  Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway.  Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity).
What are the official names of this protein?
Dual specificity protein kinase shkD, SH2 domain-containing protein 4, SH2 domain-containing protein D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily.
What are the subcellular locations of this protein?
Membrane.
Protein: SYA_TREDE
Sequence: MNKNITIDELRSKYIDFFKSKGHVEISGRSLIPENDPTVLFTTAGMHPLVPYLMGEPHPAGTRLTDVQKCVRTGDIDDVGDASHLTFFEMLGNWSLGDYFKKESIAYSFEFLTDEKYLGIPIDKLSFTVFEGNEDAPRDEESASIWESLGVSKDRIFFLPKEDNWWGPAGETGPCGPDTEIFIDTGKPACGSNCRPGCNCGKYVEIWNNVFMQYHKNMDGSYSPLKRKCVDTGMGVERTVAMLQGKPSVYNTEAFTSIIKSIEDISGVKYGDNEKTDTSIRIIADHVRTACFILGDPKTTLPSNIGAGYVLRRLIRRAVRHGKKLGIDGNFLSVPASAVIAQNAGFYTELKENETLILTELKAEEDKFLETLKKGEAEFEKMLPNLLKNPKKIIPGRMAFKLYDTYGFPIELTEELASESGLTVNREEFDEAFKKHQELSRAGSEQVFKGGLADHSEQTTAYHTATHLLHKALRMVLGDHVQQKGSNITAERLRFDFSHPEPMTEAEKKEVERLVNEAIKADLPVTMEVMPLEEAKKIGAMALFGEKYEDVVKVYKIGDFSTEVCGGPHVERTGSLGRFCIKKEQSSSSGVRRIRAVLEH
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_SHIB3
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRRETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFICYARKQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLNAHYTALETRFWQFYPRMMAQASHKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: RBSD_EXIS2
Sequence: MKRHGILNSQISKVLADLGHTDTIVIADCGLPIPAGVARIDLALELGTPSFVDVVRIVADDMAVEQVTLATEIKAANPVALEAVMKLDVPQDYVSHEAFKELTKQAKVIIRTGEATPYANVILHAGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_CHLTE
Sequence: MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAITKTSAKLGLETTFVHGKRVTDRQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADTILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAPIGYDMEGNIYNINADDAAAAIAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDGGVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKBP2_NEUCR
Sequence: MKSIFLSLSLLASATVGVLAAEELGIDVTVPVECDRKTRKGDKINVHYRGTLQSNGQQFDASYDRGTPFSFKLGGGQVIKGWDEGLVDMCIGEKRTLTVPPSYGYGQRSIGPIPAGSTLIFETELIGIDGVPKPESIVYKQAAEKAEEAASAVEEKVAEATDKAGGKIADATKKVEEKAEEASANVVEKVASVVSGAAEAVKTVVADTDDVQEHNEL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
FK506-binding protein 2, FKBP2, FK506-resistance protein 5, NcFKBP22, Peptidyl-prolyl cis-trans isomerase fkr-5, PPIase fkr-5.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RL31_ACIF5
Sequence: MKSNIHPKYEEITVTCSCGNVFKTRSTANRDLHIDLCSECHPFYTGKQRAVSAAGQVEKFRKRYGGGQ
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MIAA_ESCF3
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEIDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: COXX2_NATPD
Sequence: MQRFTGLVTATTLATYLLVVLGVATELTGGVSPAAVAHYVTAGAVWLLLVAAAALAWRDSRLPRVKWGVTAAAVAYPAQAAVGMAVLASGGPGQLHLFGGVGVFALLLITLTWHLDREVEPRERAAATAFNREGDGDDSVLLYRLPDGLRRYVELTKPRLMWLLCLLALSGMALATVTGAALDGVTIAATLFGGVLAVGAAGTFNHVYERDRDRRMNRTADRPVATDAVGVGRATAFGVGLLVVSMAVLVWLVNPLAAALTAVAVVYYAVVYTVVLKPTTTWNTVIGGGAGALPAVIGWAAVAGSIGLPALLLAAVVFCWTPAHFYNLAIAYRDDYARGDYPMLPVVAGVAATRRRILYWLGATLLVAGALGAVAGFGPVYALTSAVVGFGFLWTVVVQFRTESDRDAYRSFHASNAYLGALLVAILVETMVI
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 2, Heme B farnesyltransferase 2, Heme O synthase 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QUEA_SHELP
Sequence: MRVADFSFDLPDELIARYPMPNRTASRLLTLDGNSGAVADKQFTDILEMVNPGDLMVFNNTRVIPARVFGQKQTGGKLEILVERMLDDKRILAHVRSSKSPKPGTIICLDGGYEMTMLARHDTLFELELNSESTILEVLEEVGHMPLPPYIDRPDEDADKERYQTVYNQNPGAVAAPTAGLHFDDALLAALKEKGVNVAFVTLHVGAGTFQPVRVDSILDHKMHSEWAEVPQDVVDSIKATKAAGNRVIAVGTTSVRSLESAAKASEGELQAYSNDTDIFIYPGYEFQVVDAMVTNFHLPESTLIMLISAFAGFDEVKNAYQHAIAQKYRFFSYGDAMFVTKKAI
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGF16_HUMAN
Sequence: MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR
What is the function of this protein?
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
What are the official names of this protein?
Fibroblast growth factor 16, FGF-16.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: ROCK_CAEBR
Sequence: MEQDELLHQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERIVESVAALRMKATDFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHNMGYIHRDVKPDNMLISRSGHIKLADFGTCVKMNSNGVVRCSTAVGTPDYISPEVLRNQGKDSEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYANIMNHQTSLRFPDEPLISTQAKDIIKKFLSAAPERLGKNNVDEIRNHKFFKNDEWTFETLKDATPPIVPSLKSDDDTTHFEEIETRDRDNASDFQLPKTFNGNQLPFIGFTYSNEYSPVKKLLNGASSNGVQNGVENKPVVVQQPLTNGHSTGIPEEQYEEVVIELDSKKRELESLKDSISRTEIRAKLIETEKNSLSSKINDLERELKDNKERLRLGADSDTKVNELSVELRMSKEYNGEMENELSKFRDKCEQLKEDLRKKSGELAQEKNETQRVLQQKKNAEEAFAEIKRDHEMLQTREAEKSLQLKKALDERKENGAYQQSVAKATDAEWERKMQYYEKQLEQATDDRKREEQKRTAAEFDQSRVARKLAGIEANYELLQNDYTNMKEARKDLERDLQDVIAEKRRLEIRVEQLMDSRNTDERVLNLCQEELLESQEEAKYKEDGLRGKIDGIRNELENEKMKSQTLEENLIVADKERGMLKMEVQELMQRHKWEMANKEQNLKHIENQLEELKEHSRIESTEQESNDKKTIADLNKKLELEKAHKKAVINKLEEEMAKRQPLKKGDKGITKSALIKKEREIVGFKKCRTGRILMSLQQENQHLQQKMTEMYMDSEKQGEHFSYQMQEMSQLIETLRDELKEYKDEYPQRHSVNRYEDKRSLDSREGIPTSISHQNIQIDGWLSLRDMTKKSRKPKVVFKKKSDHQLTLFFQWTNYFVILNEYAFTIYTDEKHLNSVVLTIEAGAMAHVRHVTSADLRNVDDNQLPKIFHIMYDDTSSNSSRHASNSDLSICEPREEGWKRHDFQELSYHTRTYCDDCGKKLSDFIRPTPAFECKNCHYKTHKEHIAQGTITMCRYTGLSRELVLMGTHKEVCNQWVSQLRRFIEASRPANVSVSRVSSRRHVGGPGSSA
What is the function of this protein?
Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis.  Required for P-cell migration.  May also play a role in oocyte cellularization (By similarity).
What are the official names of this protein?
Rho-associated protein kinase let-502, Lethal protein 502, Rho-binding kinase let-502.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Colocalizes with nmy-2 myosin thick filaments at the cleavage furrow.
Protein: RPO1C_METM5
Sequence: MQMADLEKKLENSVLPPLLKRELSEKILKDGLSEEYLVDEIISETTRAYERTLVEPGEAVGVVAAQSIGEPGTQMTMRTFHYAGVAELNVTLGLPRMIEIVDARKEPSTPTMTIYLNDEFKGDREKASMVAKNIESTNVESVSEDISVDLVNECITIILNSQQLESRGLTVPDVIEAIKSKMKLKIDDHENVLNLKIKTPSLKALRKRLPKVRAIHLKGVQNIKRVIIRKEVDEYILYSEGSNIKEVFDIEGVDTTKTTTNNIVEIQDVLGIEAARNAIIYEMDATLGNQGLTVDKRHLMMVADLMCTDGVVKPIGRHGIGGEKASVLARAAFEETVKHLYSASMRGYVDELGGVVENIIVGKPIAMGTGCIDICIDKTYEEGKEL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.