PharMolix/UniProtQA huggingface dataset:
Protein: LV140_HUMAN
Sequence: MAWSPLLLTLLAHCTGSWAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSG
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
What are the official names of this protein?
Immunoglobulin lambda variable 1-40, Ig lambda chain V-I region NEWM.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: RPOB_MARMS
Sequence: MAYSYTEKKRIRKDFGKLPPVLDVPYLLAIQLESYRNFLQEGKSLAERGELGLHGAFKSVFPMVSFSGNAALEYVDYRLGKPVFDVKECQLRGVTYAAPLRVRVRLIIYDKESSNKAIKDIREQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLHSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPATILLRALGYGTEQILDTFFDSTRFYLKRDGFEMDLVANRLRGETALFNIADANGELIVEEGRRITAKHIRVMEKSGLERLSVPLEYMLGKVTAKNLVHPATGELIAEANTELSVDLLEALVSSGITEVDTLYTNDLDNGPFISDTLRIDPTSNQLEALVEIYRMMRPGEPPTKESAEGLFQGLFFSEDRYDLSGVGRMKFNRRLGREEDTGAGVLDNDDIVAVLKTLLDIRNGNGMVDDIDHLGNRRVRSVGEMAENQFRVGLVRVERAVKERLSMAEADGLMPQDLLNAKPVAAAIKEFFGSSQLSQFMDQNNPLSEVTHKRRVSALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLSTYARTNSYGFLETPYRKIVDGKQTDETVYVSAIDEAKYVIAQASANVDAEGRLVDELVQVRHMHETTLIPKEKVNLMDVSPRQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLKADKPVVGTGMEKNVAKDSGVCIVANRGGVIESVDASRIVVRVNSEETIAGEAGVDIYNLTKYVRSNQNTCINQRTLVMKGERIASGDIMADGPSVDMGELALGQNMRIAFMPWNGFNFEDSILVSERVVEEDRFTSIHIQELTCVARDTKLGPEEITADIPNVGEGALSKLDQSGIVYIGAEVEPGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSQRVKTGTRGTVIDVQVFTRDGIEKDDRAKFIEKSQLDQVRKDLNEEFRIVEKATFERLAEALIGQQAEGGPGLARNAIITEEYLANLDHPEWFKIRVANEDASEQLEKAQAALIERRKELDAKFEDKKRKLQTGDDLAPGVLKIVKVYVAIKRRIQPGDKMAGRHGNKGVISKIMPVEDMPYDENGDPVDIVLNPLGVPSRMNVGQVLETHLGAASKGLGRKINEMLVVEREKAEAVAELRSFLGEIYNGYEGDLRCARTEDLDSFTDEEILTLASNLTGGVPMASGAFDGAKESEIKRMLRLAGINESGQVKLFNGRTGDAFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLVKEIRSLGIDIELENE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CAV2_CHLAE
Sequence: MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSGQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVFIAPLCTSVGRSFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: EI3F1_DROPE
Sequence: MSALNLTVRVHPVVLFQVVDAFERRNAESHRVIGTLLGSVEKGVVEVTNCFCVPHKEHDDQVEAELSYALDMYDLNRKVNSNEAVVGWWATGNDVTNHSSVIHEYYARECNNPVHLTVDTSLQGGRMGLRSYVCIQLGVPGGKTGCMFTPIPVELTSYEPETFGLKLLQKTVGVAPANRPKTVPPMLDLAQISEASTKLQSLLDLILKYVDDVIAHKVTPDNAVGRQLLDLIHSVPHMSHEQFTQMFNANVRNLLMVITLSQLIKTQLQLNEKLTFLPTA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F-1, eIF3f-1, Eukaryotic translation initiation factor 3 subunit 5-1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_FRATN
Sequence: MKRTFQPSNLKRKRTHGFRARMKTLSGRKVIRNRRAKGRAKLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ATPD_RICCN
Sequence: MNKGNLIKNYAVALLNNAMVDNIQDKIFEEITSINRIITDNFDIREFLFSPIVNKNDKINAVNSLAKNIKISTIVQNFLLLLVKNSRTAILSNIVDAYNTLLYESKNIKIVQVISANKLQPKEQEWIKSRIEKELNQTTEILFDIDNTIIGGIIIKYDSMLQDYSIKGSLEKIKKALKIVNIAV
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y2370_YERPP
Sequence: MNINVANLLNGNYILLLFVVLALGLCLGKLRLGSIQLGNAIGVLVVSLLLGQQHFAINTEALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSAMILALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHTMANGSSLQQAQDNLSLGYALTYLIGLVSLILGARYLPKLQHQDLPTSAQQIARERGLDTDSQRKVYLPVIRAYRVGPELVAWADGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQVGDEISLVGYPDAHSRLDPSFRNGKEVFDRDLLDMRIVTEEIVVKNSNAVGKRLSHLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKSVAEKIGFISIHSQVTDLLAFCSFFILGLMIGLITFQFSNFSFGIGNAAGLLLAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGGGINSSLGAVGGQMLISGLIVSLVPVVICFVFGAYVLRMNRALLFGAIMGARTCAPAMDIISDTARSNIPALGYAGTYAIANVLLTLAGSLIVILWPGILG
What are the official names of this protein?
Putative transport protein YPDSF_2370.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGD_BACCR
Sequence: MTSHLFQTYGRRTIEFVKGTGTKVIDNKGKEYLDFTSGIGVCNLGHCHPTVLKGVQEQLDDIWHISNLFTNSLQEEVASLLTENRALDYVFFCNSGAEANEAALKLARKHTGKSLVVTCQQSFHGRTFGTMSATGQDKVKEGFGPLLPSFLHIPFNDIKALEEVMNEEVAAVMVEVVQGEGGVIPVDLSFLKEIETLCNKFGSLFIIDEVQTGIGRTGTLFAYEQVGIEPDIVTVAKALGNGIPVGAMIGGKELGTSFTAGSHGSTFGGNYIAMAAAKEVLQVSKKPSFLKEVQEKGEYVLEKLQEELQHVECIQNIRGKGLMIGIECKHEVASFIEQLENEGLLVLQAGPNVIRLLPPLIVTNEELEQAVYIIKKVVCTKNVSII
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_STREM
Sequence: MSNILRKVIENDKGELRKLEKIAKKVESYADYMESLSDKDLQAKTPEFKQRYQNGETLEQLLPEAFAVVREAARRVLGLYPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNALAGKGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYLCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADMFVKTLDSVDYIIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFVDNALRANYIMLLDIDYVVSEEGEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIARIDHTDLLYATLNSKFKAVVADVKARYEKGQPVLVGTVAVETSDLISKKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDELMRRFGTDRIKAFLDRMNHDDEDIVIKSRMLSRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHSRTNRKDAIDAIVTFARTSIVPEETIGAKELRGLKDDQIKDKLYQRALEIYDKQLSKLRDQDAILEFQKVLILMIVDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQSEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERATQYATTTAAQNIQSQAIGADFDSSADFSRVERNDACPCHSGKKFKNCHGRKAF
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: WDR5_XENTR
Sequence: MATEEKKPETEASKTQSTPSSSNNQSKPAPVKPNYTLKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTCHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEVVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
What is the function of this protein?
Contributes to histone modification.  May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'.  As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.  May regulate osteoblasts differentiation (By similarity).
What are the official names of this protein?
WD repeat-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR5/wds family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1172_CAMJE
Sequence: MGRAFEYRRASKEARWDKMSKLFPKLAKAIQVAAKEGGTDPDMNPKLRSAIATAKANNMPKDNIDAAIKRASGKDSADIKNIHYEGKAAHGALVIVECMSDNPTRTVANVKAIFSKNGGEVLQNGSLGFMFTRKAVFHLEKFAGDLEELELDLIDAGLEELEQNEEELVISGDYTAFGELSSAIEAKGLVLKKAGLEYIPNNPVSFSEEQLSDIEKLLDKLEDDDDVQAVYTNID
What are the official names of this protein?
Probable transcriptional regulatory protein Cj1172c.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2AY_HUMAN
Sequence: MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
What is the function of this protein?
May function as a testis specific transcription factor.  Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
What are the official names of this protein?
TFIIA-alpha and beta-like factor, General transcription factor II A, 1-like factor.
What is the protein family that this protein belongs to?
Belongs to the TFIIA subunit 1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
Protein: TIG_BURM1
Sequence: MANVVENLGKLERRVTISLPKETVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYAGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFAPKQEQSDDAYAFDATFEVYPEVKIGDLSTAEVERSTTTIGDAEIDRTLDILRKQRVHFHARGEAGEHGDGGADTAAQNGDRVTVDFVGKIDDVAFPGGTAEDFPFVLGEGRMLPEFEQAALGLKAGESRTFELKFPDDYHGKDVAGKTAQFTVTMKKVEWPHLPEIDAEFAKSLGIEDGDLAKMRNEIKENLEREAKRRTQAIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFAEQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASASAQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: BIOD_BACAC
Sequence: MSGFFITATDTEVGKTVVAGALAGVFRELGYNIGVYKALQSGHVASNPEGDAARLKVLSGVPIKEDEICPYSIEEPLAPRLAMKRAGRAVTLKDIIHHYNERLKEFNSLFVEGAGGLAVPYTEDALVIDFAKELQLPLIVVARPTLGTVNHTVLTIAYAKAHGLTVAGVILSGCKECEMERVQENKVMIEELSGVPVLGLLPFFEGEFTKEEVLESAKEYIMISKLEEFIRNESTVAHTSSN
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_PSEU2
Sequence: MSEYSLFTSESVSEGHPDKIADQISDAVLDAIIAEDKYARVACETLVKTGVAIIAGEVSTSAWVDLEDIVRNVILDIGYNSSDVGFDGATCGVMNIIGKQSVDIAQGVDRSKPEDQGAGDQGLMFGYASNETDVLMPAPITFSHQLVQRQAEARKSGLLPWLRPDAKSQVTCRYENGKVVGVDAIVLSTQHNPDVSYKDLREGVMELIVKHVIPAHLLHKDTQFHINPTGNFIIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISLNTFGTGKLSDDKIIKLVRDNFDLRPYAITTMLDLLHPMYQATAAYGHFGRIPVEMTVGDDTFTAFTWEKTDRADALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y717_DESRM
Sequence: MFDIKEDQNGVVVKVRVQPRASKNSLAGEMEGALKVRLTAPPVDGAANEACCKFFGELFGVAKSKVEIIAGHTGRNKLVHIQGVTEKQARFILK
What are the official names of this protein?
UPF0235 protein Dred_0717.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: ULAE_ECOSE
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDERLSRLDWSREQRLALVNAIVETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQEANNETRRRFRDGLKESVEMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAEDPAAEVAKARDWVKARMAKAGMVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: MECA_STRT1
Sequence: MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVNKSDLKEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAFSDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDALPVLQATKWS
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: ESM2_DROME
Sequence: MYLDTKNLTASSTSALTAATASNSKSTRRMRNVWKPLSRLLKVGGKGRTAQATLAHPNNVDLNNTQQQQQQQQQELLIEDDTKSTPEESIHKYGLELRQLPEEEQVSLTQPPNTPTLISSVHVDKVSAQSCGNCQHGRNCQHRHHSSSNINSSSSSSNMNSSSATQLPSNLWDLQLPLQYISTDNGTFFWANTQDRVDDDLLHALLCQSFSQLPGTLC
What is the function of this protein?
Part of the Notch signaling pathway.
What are the official names of this protein?
Enhancer of split M2 protein, E(spl)m2.
Protein: COXX_JANSC
Sequence: MSDFTAQTTTEPREYDAGFGDYFALLKPRVMSLVVFTALVGILVAPGGVSPMIGFTAILFIALGAGASGALNMWYDADIDAVMKRTAKRPVPAGKVPAGEALTLGLWLSAISVAMLGLATNWVAAGLLAFTIFFYAVVYSMWLKRATPWNIVIGGAAGSFPPMIGWAAVTGDVSLASVLMFGIIFMWTPPHFWALALFLKKDYNNAGVPMLTVTHGRTETRRQILIYTILLVPVALGLVLTEVAGPVYLITALVCNAIFLKGAYDIWKRDEAMAEADGYAVEKKVFKFSLLYLFLHFGALLLDAIWRLI
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD_SHIB3
Sequence: MAEKFIKHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPDFVLNFPQYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVKLSDAEVDELFALVKANPGIHFDVDLEAQEVKAGEKTYRFTIDAFRRHCMMNGLDSIGLTLQHDDAIAAYEAKQPAFMN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: SFH13_ARATH
Sequence: MSGVEEISTLDEFRERRSDFEISEDERRRSKIGNLKKKAINASTKFTHSLKKRGKRKIDYRVPAVSIEDVRDEKEESVVLEFRRKLLERDLLPPRHDEYHTLLRFLKARDLNIEKTTQLWEEMLRWRKEYGTDTILEDFDFEELEEVLQYYPQGYHGVDKEGRPVYIERLGKAHPSKLMRITTIDRYLKYHVQEFERALQEKFPACSIAAKRRICSTTTILDVQGLGIKNFTPTAANLVAAMSKIDNSYYPETLHRMYIVNAGTGFKKMLWPAAQKFLDAKTIAKIHVLEPKSLFKLHEVIDSSQLPEFLGGSCSCFGDGGGCLRSNKGPWNDPEIMKLIYHGESSLFRQSTRKLTDPHYSSSYISIHPSKAIQAETSAAESISCSDVPSSPTGRLCSASSHVNSAYEEARASDVNGYYSCDDKFAIPDKATNRKGQERQSQYQMRELNATTIGLKCETSSPGAPIIRWLHDLRVMIDKIKCENLAKRLLSLMLKLAAVFRYTPLELLRSQTTVSPSSLTEDDSRCSLISPPPREPTMKDRILPCLERIQKLEKSYEDIRNKPVAIPVEKERMLMDSLDRIKSVEFDLDKTKRLLHATVMKQMEITEMLQNIRDSQLHRRRRLFC
What is the function of this protein?
Required for transport of secretory proteins from the Golgi complex.  Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).
What are the official names of this protein?
Phosphatidylinositol/phosphatidylcholine transfer protein SFH13, Protein SEC FOURTEEN HOMOLOGS 13, AtSFH13.
What is the protein family that this protein belongs to?
Belongs to the SFH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Protein: MKS1_DROME
Sequence: MQKSRDIKRTGVYRVSGNIGDLQLELKLRHISEWLPVPKFEYAGAQSTNAYGDHYPGSEEDIWQDCYIHVPQGDDSCGGKTGLGYNCSYYNVGIGYTGRRRRSPISQHEGEMEKDKNEGEITDLESQSNRSWSILSDNSRPPAGDLFYKRNKELCNGAIATIRISWQQKHFSQAELEQYINNPGSCASKLQRRYHRWALETLKLQQRYLRKLENLEDAETVEDPEPITIRRRIRKPKAKQRGCSAAAHPTITSLSSANMSEVSILDDPNFAARTCLIHTLLDNDSESLMPAEASEFHKKGYQLMYIYADLQQDTLLVSIRYDPEQGLLYVYPDFSSSAQDLDYVIQIERNNDCRQLYAFGFENVTPLEAYDDDGFSEEADGEDEQELGDGLPIEEDLPEEASAEEILEFYRRRREAASERRSLLQFEMPPKRMKRVSLLLELQEGQNFENPNIHVRYYLKAPANTFYEGTPGVDTMQGATATCRNAGDWRSAHLGHCWQVTLLLEEQHHPADLLHLYFEVISIDSWQRERCEGYAHYAIPLTSALPTDSIRLQCIRPLGNWLDALNRYFIGGRQLFDFESFFDVHRQSEMHSRLNFNSDRPMTTTGTLSLRLQKLQQRQIDTSDQFHHHFHLELGNDSSDDGDSNDDDVRSSSNPDTSRATTLDEVMAAFVEARKRIELLLGNSSETASPSSAYYQAEF
What is the function of this protein?
Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273).  Required for ciliary structure and function (PubMed:27577095).
What are the official names of this protein?
Tectonic-like complex member Mks1, Meckel syndrome type 1 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and speromatocyte system (PubMed:27646273, PubMed:30013109). In spermatocytes, localizes in the transition zone and the migrating base of the spermatid ciliary cap (PubMed:25447994, PubMed:27646273, PubMed:27577095). Co-localizes with the tectonic-like complex (PubMed:27646273).
Protein: LIS1_CANGA
Sequence: MSSLTDSQVNDLHCSIYRYVQWVSQNNGSSDLLNKLQSVLDIDELQLSLDDGDQMLLPKKWGSIIRLQRAITKLEQKCDALQQELDDKTKQLETIVPKDTQIATTTDVNWLPPDHIYASIQNESPVTAIKLHPSLAIVYVGTDTGRLIAYDILNYTIPLAVTTAHSKAITSIEVIEAHNFEEFIDSTTLVSTTSKDAQINVYDHSSNTGELKLIRSFNAHDSTVSSQKTWQKDNDVLLASSSRDATVKVWRVNDSRCLQSFSPHSEWVKSIDVLDEYILSGSLDSTLRLTHWPSGNGLSVGTGHEFPIERVLIIPFSDSKICTSPYRDQNEHSAFAPLRFKYCASAARDNTIKIWEVPLPQLKPNSAPVPSTTNTTFKCVMTLRGHTSWVKDLKLRGDHLFSCSDDETIKCWDLNTGNCVKTWSSIHNNFINCIDIDREATIEQFSPSLQREILVSGDMDNKVKIIR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  Plays a central role in positioning the mitotic spindle at the bud neck during cell division.  Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles.