PharMolix/UniProtQA huggingface dataset:
Protein: PRMA_SHESA
Sequence: MPWIQLRINTNSDDAETISDLLMEEGAVSITFEDGKDTPIFEPKLGETPLWQDTVVVALFEADTDLAPTIEMLKTLPFLGEHFSHKIEQIEDKDWVREWMDNYHPIQFGKRLWICPSWREVPDPSAVNVILDPGLAFGTGTHPTTALCLEWLDSLDLSNEEVIDFGCGSGILAVAALKLGAKKVTGIDIDYQAIEASKANAERNDVADQLALYLPEDQPADLKADVLVANILAGPLRELAPLIAERVKSGGKLALSGLLKEQAQEISDFYSQWFDMDEAAHKEDWSRLTGKRK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2HC_ACAAN
Sequence: SIPLPSLNFEQFGNMIQCTI
What is the function of this protein?
Monomer: the gamma chain has no significant enzymatic activity and is not toxic by itself.
What are the official names of this protein?
Phospholipase A2 homolog P-elapitoxin-Aa1a gamma chain, P-EPTX-Aa1a gamma chain, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FRDC_VIBCM
Sequence: MSNRKPYVREMKRTWWKDHPFYRFYMVREATVLPLILFTLFLTVGLGSLVKGPEAWQTWLDFMANPLVIAINLVALAGSLFHAQTFFSMMPQVVPIRLGGKLVDKKIIVLAQWAAVAFISLIVLIVV
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENV_HV1YB
Sequence: MGMQSGWPFFCLLISLTIGSDPHWVTVYYGVPVWRDAETVLFCASDAKAHSTEAHNIWATQACVPTDPNPQEVLLTNVTEYFNMWENKMAEQMQEDIISLWEQSLKPCVKLTPLCVTMLCNNSNGNSAGNSTTNRTEDLEDRQMKNCSFNITTEIRDRKKQVYSLFYVEDVVPIKDGTDNNTYRLINCNTTAVTQACPKTTFEPIPIHYCAPPGFAIMKCNEGNFSGNGSCTNVSTVQCTHGIKPVISTQLILNGSLDTDDIVIRHHGGNLLVQWNETVSINCTRPGNNTGGQVQIGPAMTFYNIEKIVGDVRQAYCNVSEEWGSMWNKTKKKIKRLLGNNTTFKAQDKNGGDLEVTHLMFNCXGEFFYCNTSRLFNESENKTNKTIILPCRIKQIVBLWTRVXKGIYAPPIRGNLSCXSSITGLILEHSGENGNKTVYPSGGNMVNLWRQELYKYKVVSIEPIGVAPGKAKRRTVSREKRAAFGLGALFLGFLGAAGSTMGAASITLTVQARTLLSGIVQQQNNLLRAIEAQQHLLQLSIWGIKQLRAKVLAIERYLRDQQILSLWGCSGKTICYTTVPWNDTWSSNTSYDTIWXNLTWQQWDRKVRNYSGVIFDLIEQAQEQQNTNEKALLELDQWASLWNWFDITKWLWYIKIAIMVVAGIIGIRIISAIITIIARVRQGYSPLSLQTLIPTAARGPDRPEETEEGVGGQDRGRSVRLVSGFLALIWEDLRNLLIFLYHRLADSLLIIRRTLEILGQSLSRGLQLLNELRIRLWGIIAYWGKELKDSAISLLNTTAIVVAEGTDRFIELAQRIGRGILHIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: RL17_MESH2
Sequence: MANPHQIYRHDAAWDRQVFRSLATSLILHGHIKTTLDRAKRLRSVVEKIITKAKKNDLAARRQILSFLYAQKTKAGIKVMPYLFNKVAPRYQERNGGYTRIVRIPSRLGDNSKMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: AROB_STRR6
Sequence: MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSD2_ARATH
Sequence: MEDRCLIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENLPIE
What is the function of this protein?
Acts as a cysteine synthase.  The cysteine synthesis reaction is more efficient than the cyanoalanine synthase activity.
What are the official names of this protein?
Bifunctional L-3-cyanoalanine synthase/cysteine synthase D2, Beta-substituted Ala synthase 4;2, ARAth-Bsas4;2, Cysteine synthase D2, AtcysD2, O-acetylserine (thiol)-lyase 6.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_HHV7J
Sequence: MALLQWMLENISDDNSIKMSLEEQHETFQINVKWLKFLNLSDSDIVQLQNVYKLVQRDRERLIIYPDPQNVHSWSYLCSPEEIKVIIVGQDPYPDGRGHGLAFSTVRGCSPPNSLKTIFAELERTIENFKAPAHGSLKSWCAQGVLLLNTVFTVIRGVPMSHEAIGWQVLSNRIINQLSEKMQNLVFMLWGSQARKLVSLIDSKKHLILECAHPSPRTKGSKTPFIGCGHFLKANKYLQIHNKCPIDWNITNDL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: AZOR_YERP3
Sequence: MSKVLVLKSSILATSSQSNQLADFFVEQWQAAHAGDQITVRDLAAQPIPVLDGELVGALRPSGTALTPRQQEALALSDELIAELQANDVIVIAAPMYNFNIPTQLKNYFDMIARAGVTFRYTEKGPEGLVTGKRAIILTSRGGIHKDTPTDLVVPYLRLFLGFIGITDVEFVFAEGIAYGPEVATKAQADAKTLLAQVVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: BURP5_ORYSJ
Sequence: MCATLCTLLDEISILILMLLLIQLEIRVSAAQGGGSHAAMSPEQYWRSILPDSTPMPISISQLLGDGYPYSPAVGLPKRGDRVQIRYGPNIYGLAASQQFFKDPTMGLFFLETNLQSSKSIKLHFANMMAGTKFLPRGEADAVPFSSKDLQEILARFGVRPGSVDASVVKNTLLECELPANKGEKKACATSLESMVDFVASSLGTRDIKAASTFLVGKDGDTPAQEYTVTGARRMAETGQLIACHPESYPYAVFMCHLTEATRAYKASLVGKDGAAVEAVAVCHTDTAEWNPKHAAFQVLGVKPGTVPVCHFVQPDVVVWTRRG
What are the official names of this protein?
BURP domain-containing protein 5, OsBURP05.
Protein: ENTS_ECO55
Sequence: MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMIGGLLLATGGVAWNYGLAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMASAVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFLAIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEAMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRRFRQTPPQVTASDS
What is the function of this protein?
Component of an export pathway for enterobactin.
What are the official names of this protein?
Enterobactin exporter EntS.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFA_CLOBM
Sequence: MRQKLEEIKNSAINELKASLSKDQLEVIRVKYLGKKGELTQILRGMGALSQEERPIVGKVANEVRSYIEETIKEAFSDIKNKEKSIRLENETIDITMPGKKQAVGKRHPLDLTLESMKDIFISMGFTIEEGPEVELDEYNFEALNIPKNHPARGEQDTFYINDNLVLRTQTSPIQIRTMENQKPPIKMIAPGKVYRSDSVDATHSPIFYQMEGLVVDKGITFSDLKGTLELFAKRMFGDKVKTKFRPHHFPFTEPSAEMDATCFVCNGEGCKVCKGSGWIELLGCGMVHPQVLRNCNIDPEVYSGFAFGFGVDRMVMMKYGIDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNC_PSEU2
Sequence: MPIKAILTDIEGTTSAVSFVFDVLFPFARKHLPAFVREHAEQPAVAQQLQAVRDLAGEPDADVERVIALLLEWIAEDRKATPLKALQGMVWEQGYNAGQLKGHVYPDAVDALKHWHQQGYRLYVYSSGSIQAQQLIFGCSEAGDLSGLFSGYFDTTSGPKREAQSYRTIAQAMDCPAGDILFLSDIVEELDAAQAAGMATCGLARDGGALAGHRYVTSFALIDPASF
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: HDA_PECAS
Sequence: MLEVILNTPAQLSLPLYLPDDETFASFYPGENASLLAAVNNALYQEHGSYIYFWSREGGGRSHLLHAACAELSRQERAVGYVPLDKRAYFVPDVLEGMEQLALVCIDNIESIAGDEAWEMAVFNLYNRIQETGRALLLITGDRPPRQLNIRLPDLASRLDWGQIYKLQPLSDDEKGEALQLRARLRGFELPEDVSRFLLKRLDREMRTLFMTLDQLDHASITAQRKLTIPFVKEILGL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: YQGF_SALPA
Sequence: MSDTLLAFDFGTKSIGVAIGQRITGTARPLPAIKAQDGTPDWTLIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVTVTLHDERLSTVEARSGLFERGGYRALNKGKVDSASAVIILESYFEQGY
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_PROM3
Sequence: MTTTIRSGRLSSWESFCNWVTSTNNRIYVGWFGVLMVPTLLAAAICFTIAFIAAPPVDIDGIREPVAGSFLYGNNIISGAVVPSSNAIGLHFYPIWEAASVDEWLYNGGPYQLVVFHFLIGICCWLGRQWELSYRLGMRPWICVAYSAPLSAAFAVFLIYPVGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMIGVAGMFGGSLFSAMHGSLVTSSLIRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVICIWITSLGISTMAFNLNGFNFNQSVLDAQGRVVPTWADVLNRSNLGMEVMHERNAHNFPLDLAAAESTPVALIAPAIG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: TGT_ACIAD
Sequence: MFFRLDLESCMKFEKLGQSGRARRGRLTLAHGVVETPVFMPVGTYGTVKGMLPRDIEEIQAQIILGNTFHLYLRPGLEVIKEHGGLHEFIKWDKPILTDSGGFQVFSLGAMRKIKEEGVTFRSPIDGSKVFLSPEISMEIQQVLNSDIVMIFDECTPYPATHEEAQKSLQLSLRWAKRCKTHHHEQLNNTNALFGIIQGGMYEDLRDESLNGLLEIGFDGYAIGGLSVGEPKEEMIKVLDYLPAKMPEDKPRYLMGVGKPEDIVEAVRRGVDMFDCVMPTRNARNGHYFVTDGLVRIRNSKYRHDQSPLDPHCDCYTCKNFTRAYLYHLEKCGEMLASMLGTIHNLRYYQRLTQGIRDALEQGTFDEFVTDFYTRRGLDVPPAPVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PPIL4_GIBZE
Sequence: MSVLLETSAGDIVIDLLVDHAPKLCENFLKLCKVKYYNFSPVHSVQKNFSFQTGDPLGPLSKDSDGGSSIWGHLSGDPSERTFPAFFHPKLKHLERGTVSMATAPLQSDPDVRVAGSQFIITLGQDTDFLDGKAAIFGKVVEGFEALDKINEAIVDEKGHPLIDIRIKHTVILDDPYADPPGLREPSTSPPPTDQQLKTVRIADEAALHEDDNVDEEELERRRRNREAQAQALTLEMMGDLPFAEVKPPENVLFVCKLNPVTGDEDLELIFGRFGKILSCEVIRDQKTGDSLQYAFIEYEDKASCEAAYFKMQGVLIDDRRIHVDFSQSVSKLSDVWRKDTNSKRRTNAGRGGWGGVDELEKRRQYRDEGERVTGGNYRMVYGEEEMKGKVGRNAPKQDKDDGPPPPGPRDNGEPSRQQNRSRSPRPRDRSRDRYHKPRDDRRGDRRDRDRRDQDRNRYRDRDHRDRGREKDRYGRDENDRRSRR
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 4, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2735_CITK8
Sequence: MPSFDIVSEVDLQEARNAVDNATREVESRFDFRGVEATFELNDANKTIKVLSESDFQVNQLLDILRAKLLKRGIEGSSLDVPEAFVHSGKTWFVEAKLKQGIESAVQKKIVKLIKDSKLKVQAQIQGEEIRVTGKSRDDLQSVMALVRGGDLGQPFQFKNFRD
What are the official names of this protein?
UPF0234 protein CKO_02735.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: DHH1_PICGU
Sequence: MSDDWKANLNIPAKDSRPQTEDVTKTQGKSFEEFGLKRELLMGIFEAGFEKPSPIQEESIPMALAGRDILARAKNGTGKTASFIIPALQQVKTKLNKIQVLILVPTRELALQTSQVVKTLGKHLKLQCMVTTGGTLLRDDVMRLDEPVHILVGTPGRVLDLAARSIADFSECPMFVMDEADKMLSREFKGIIEQILEFFPKNRQSLLFSATFPLAVKSFMDKHLNKPYEINLMDELTLRGISQFYAFVEEKQKLHCLNTLFSKLKINQAIIFCNSTNRVELLAKKITELGYSCYYSHAKMPQQARNKVFHEFRQGSVRTLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAINFIHWDDRKSLFNIETELGTEIKPIPSDIDRSLYVTEDEASIPRPFKIDELPKGNEHSRKRNGYEYRGQPTSQGFPQQPPQANTGYNQVPQGSPQAQGLQGSPQGLQGSPQGIPQGSPQGIPQGIPQGLPQGVPQFPQGYPQGIPPQGPQAYQNYQIPPQQVPAQFNGHSQYSQYQSQPF
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHH1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: PCNA_NATPD
Sequence: MFKAIVSADTLGAALDSVSVLVDECKVRLDEEGLTIRAVDPANVGMVDLELSASAFESYETDGGVIGVNLDRLEDIVGMADSGQLVHLDLDEETRKLHISLDGLEYTLALIDPDSIRQEPDLPDLDLSSEIVIEGADIDRAVTAADMVSDHIALGVDPDAEEFYVDAEGDTDDVHLELDREDLIDLTPGEARSLFSLDYLKDMNKAIPKDAEVTMELGEEFPVKMHFDFAEGDGHVTYMLAPRIQSD
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: INSM1_HUMAN
Sequence: MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC
What is the function of this protein?
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development.  Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters.  Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner.  Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway.  Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases.  Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism.  Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412).  Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex.  Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system.  Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
What are the official names of this protein?
Insulinoma-associated protein 1, Zinc finger protein IA-1.
What is the protein family that this protein belongs to?
Belongs to the INSM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL21_TREPA
Sequence: MYALIEYKGKQYKVERGSSIVVDNISEVAPGGCIDVREVLMIGGEGLTRIGSPYLEGVGVRAVVGECFRSRKITVYKYKSKKDYHRTIGHRQWYTRLTVSDILGV
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ALR_CITBB
Sequence: MDSRPTVVEIDLAALRHNFSLVQKRVPEGCGLLAVVKADAYGHGFQYVSEELEKLGVDAFAVAFLAEGVQLRMSGITRPVLILGGIYPGEERRCIGLNISTALFSLEQAAALDQAALEIKCYRKAHIHLKVDTGMGRLGVPYHEVPEFLAKLKQFKNLELEGIFSHFASADELDPEGIAFTKLQAERFNAAVEEARRQGYAPTYVHVANSAAILTQDLPYCNLARPGIILYGALPSGDFEGQVPSQPVMRLKSRVAMLKWVEPGTSISYGRRYVAAERALIASVPVGYADGYCRSLTNKGEALIRGQRAKVAGTVCMDWIMLDVTNVKGVAVGDDVTLLGPDPMGDCISAEEMAEKAGTIPYEVLCGIATRRVRRVYLG
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: THPR_PYRHO
Sequence: MRAFIAIDVNESVRDSLVRAQDYIGSKEAKIKFVERENLHITLKFLGEITEEQAEEIKNILKKIAEKYKKHEVKVKGIGVFPNPNYIRVIWAGIENDEIIREMAREIEDELAKLGFKKEGNFVAHITLGRVKFVKDKLGLTMKLKELANEDFGSFVVDAIELKKSTLTPKGPIYETLARFELSE
What is the function of this protein?
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
What are the official names of this protein?
RNA 2',3'-cyclic phosphodiesterase, RNA 2',3'-CPDase.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. ThpR family.
Protein: Y435_METJA
Sequence: MNINEIKRKIIPILLKHGVKRASIFGSYARNEQKETSDIDILVEFGEGKSLLDLVRLKYELEEVLGKEVDVLTYNSIHPLLKDRILNEAVDVL
What is the function of this protein?
Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system.  Neutralizes cognate toxic MJ0434 by di-AMPylation.
What are the official names of this protein?
Putative protein adenylyltransferase MJ0435, Putative antitoxin MJ0435.
What is the protein family that this protein belongs to?
Belongs to the MntA antitoxin family.
Protein: ATPG_LATSS
Sequence: MAESLMDIKRRIASTKKTGQITSAMQMVSGAKLSQIEKNSVAYQVYTDKIREIVTHLAASQLIDIARQKSSLQAEPADSTIKKAIKHEVTLSNLLVERPIKKTGYLVITSDRGLVGAYNSSILKAMVQMISETHQSPDEYAILAVGGTGADFFKARGMNLTYEYRGVSDVPSFEEVKQIIKTAVAMYDNGVYDELYVCYNHHVNSLTSGFRAEKMLPITDLDVSEVADQNLEYITEPSVDDALDAILPQYAESLIYGAMLDSKTAEHAASMAAMKSATDNANNLISELSIKYNRARQAQITTEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.