PharMolix/UniProtQA huggingface dataset:
Protein: C4S1B_XENLA
Sequence: MSDFWHKLGCCVVEKPQPKKKRKRIDRSMIGEPMNFVHLTHIGSGDMGASDGLPKAGTVQEQMRSKCGRDRQWSNSRVL
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
What are the official names of this protein?
CDC42 small effector protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Protein: TATA_POLNA
Sequence: MGGFSIWHWLIVLLIVVMVFGTKKLRNMGSDLGGAVKGFKDGMKDGGQSPADEKPVVPASQVTNAQAADKAERNTIDVEARQKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MOS_MSVMO
Sequence: MAHSTPCSQTSLAVPNHFSLVSHVTVPSEGVMPSPLSLCRYLPRELSPSVDSRSCSIPLVAPRKAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDLRASQRSFWAELNIAGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKALQNIIQSCWEARGLQRPSAELLQRDLKAFRGTLG
What are the official names of this protein?
Serine/threonine-protein kinase-transforming protein mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: DNLI_PYRNV
Sequence: MQFGELVKTLAAVESTTQRTTMVKLLTSLLKRARPDEVDKIVYFVLGDLKPPWEGVELGVAEKLCLRAVSKAAGTPLSELEAVYKRTGDVGEAARRALSAAKRPGLLAFGQQKPLEVSEVYDTLLKVAKAAGEGAQDMKISLLASLFARATPEEAKYIARFVVGKLRLGVADMTLLEALSEAFGVGKEALERAYHVWPDMGKLARHVAEGRPLEEVKITPGVPVLPMLAQRLSSASEILAKLGGAAVCEYKYDGERAQIHISGGSVKIFSRRLEDITHAYPDVVKAVKESVAAGEAILEGEIVAVDPDTGDMLPFQELMHRKRKHEVAAAVESYPAVLNLFDVLYLDGEDLTGEPLIYRRLRLSEVVHETEKVSIARWRLFDDPGEVDVFFHEAVSLGMEGLVCKSPTSIYEMGARGWNWIKYKRDYKSEMIDTVDLVVVGAFYGRGKRAGLYGAFLLAAYDPQTDMFYTVCKVGSGFTDADLKKMYEVLQPYKIPHRHPRVVSKMTPDVWFTPQVVIEVIGAEITLSPLHTCCLGAVRPGVGLAIRFPRFTGRYRTDKSPEQATTPAEMVELYKRQKKVAQPE
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: POTA_RUBXD
Sequence: MERQNTAERRQGAREEGRPVAVRLQNVTKRFGDFTAVEDLSLDIHEGEFFSLLGPSGCGKTTTLRMIAGFEEPTEGEVVVAGRSMRGVPPYRRPVNTVFQSYALFPHLDVFENVAFGLRRAGVPKGEISRRVGEACALVKLSGFERRKPSRLSGGQQQRVALARALVNRPKVLLLDEPLGALDLKLRKQMQLELKNLQHEVGITFIYVTHDQEEALTMSDRIAVMNEGRVQQVADPATLYELPANRFVADFIGQTNILEGTVEAVEGERAVIRTAGGLRLEAVAPNGFRPAVGEAVEAAVRPEKLRVGEAGDNVVAAEVAEVVYLGSSTQYILRAPDGGRLVAHRQNDREAAALRPGEAVSVAWDARHCLILGGKRG
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MDH_BACHK
Sequence: MTIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANIIGTSDYADTADSDVVVITAGIARKPGMSRDDLVATNSKIMKSITRDIAKHSPNAIIVVLTNPVDAMTYSVFKEAGFPKERVIGQSGVLDTARFRTFIAQELNLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGSAYYAPAASLVEMTEAILKDQRRVLPAIAYLEGEYGYSDLYLGVPVILGGNGIEKIIELELLADEKEALDRSVESVRNVMKVLV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: Y3618_SOLUE
Sequence: MLHWSLVFLVFALIAAVLGFGGLAGAAVGIAKILFFVFLVIWLVAFLMGRRAI
What are the official names of this protein?
UPF0391 membrane protein Acid_3618.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LYRA_STAES
Sequence: MKNSRFSGFQWAMMVFVFFVITMALSVILRDFQATIGVKRFVFSIKDLAPFIAAIVCILVFKHRKEQLAGLKFSISLKVIERLLLALILPLIILMIGLFSFNTYADSFILLQTSDLSVSLLTILIGHILMAFVVEFGFRSYLQNILETRMNTFFASIVVGLIYSVFTANTTYGVEYAGYHFLYTFMFSMIIGELIRATNGRTIYIATAFHASMTFALVFLFSEETGDLFSMKVIALSTTIVGVSFIIISLIIRAIVYKTTKQSLDEVDPNNYLSHIQDEEPSQEDASSTSNHDVSSKDETKQQDIDNDKHQSKKPNKSDDALTTSNYKEDASSVNKETDTTHNDNIKDHSTYTEDRHSSVVNDVKDEIHEVEDHKADTDKSH
What are the official names of this protein?
Lysostaphin resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the LyrA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLQ_LACLA
Sequence: MNEDLIAEIQALSAIGSEEKFSEIIRLLKNSTLELRGKKNPDLQLSASALVFKKHKLFFIEHPYQKELLLPAGHVELGEKPLETAIREFHEETGFSASESGKLVDVNLINIPYNKIKNEKEHQHIDFRFLLELKEKEAGLAELPFFLLDRTEAPDEFKKYYQYKR
What is the function of this protein?
Probably mediates the removal of pyrophosphate from dihydroneopterin triphosphate (DHNTP), a possible step in the pterin branch of the folate synthesis pathway.
What are the official names of this protein?
Probable DHNTP pyrophosphohydrolase, Dihydroneopterin triphosphate pyrophosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: SLX1_BRUMA
Sequence: MSADESNIICIEDDEENIEESGVKYSDKLPVCQGSSKILCRSSSQEVIQENERKKRGKNYAVPSILDDFFGVYCLLSRSPNRYFKNRCYIGYTVNPNRRIRQHNAGKEFGGAKKTDHRGPWDMVCIIHGFPNSVSALRFEWAWQNPEKSRRLRLLNLKKRTSETAFGFRLRIACHMLNSDPWRRLSLTFRWLLPELEIPFPLDVLPPSHIAVEHGAVTKISTLIPQLQEEYDVAGTCSLCLKPILSISELLRCHANETCKSHFHMRCLSKHALNAVDEYRTSLFPIQGQCPKCGVVYLWGDLIRDQRILLAVNKFNSSSTLFNMIPRGKLIKM
What is the function of this protein?
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSAD_RHIL3
Sequence: MVPFLRILGIETSCDETAAAVVERDAEGHSNVLSDVVLSQLDEHSAYGGVVPEIAARAHVEALDELIEEALKRANVSLNDVDAIAATSGPGLIGGLLVGLMTGKAIARAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLILVRGVGQYERWGTTIDDALGEAFDKTAKLLGLPYPGGPAVERMARDGNPDRFDFPRPLVGEARLDFSFSGLKTAVRQAAQDIAPLSDQDVADICASFQKAVSRTLKDRIGRGLQRFKTEFPATGEKPALVVAGGVAANLELRGTLQALCNKNGFRFIAPPLHLCTDNAVMIAWAGLERMATGAAPDTLDVQPRSRWPLDSNAETLIGFGKRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEIOC_MOUSE
Sequence: MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH
What is the function of this protein?
Is required for meiosis completion in both male and female germ cells.  Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I.  The function may involve YTHDC2 and is independent of induction by retinoic acid (RA).  Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054).
What are the official names of this protein?
Meiosis-specific coiled-coil domain-containing protein MEIOC, Meiosis-specific with coiled-coil domain protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=at late pachytene a fraction is nuclear.
Protein: PNP_PARUW
Sequence: MQRETISVPVGAQEIIFETGKIARQAGGAVVVRCGETVVFTTACAAPNADSTTDFLPLRVDYQEKFSSAGKTLGGFIKREGRPTEKEVLVSRLIDRPIRPMFEEGYYNEVQLLSFVWSYDGINSPEPLAICGASAALVISDIPLIKPVGAVRIGFIDAQFIVNPTIEQQKQSKLDLLIAGTEEAVLMIEGFCDFLTEDQVLEAIEIGHRSIKTICQTLEQWRAKVGKPKNRETLRQLPKELYADVESIANPLLEKALRICEKQKREEALAEVTKAVNDRLMPENEEPKYPAKHIAYVIKDVSSKMMRQMILNENVRSDGRTSTDIRFIDIEQSLLPRAHGSSLFTRGETQALAVCTLGGASMAQRFEDLEGEGNNRFYLQYSFPPYSVGEVGRVGAPGRREIGHGKLAERALMAVIPTKEQFPYTIRLESNITESNGSSSMATVCGGCLALMDAGVAIKRPVAGIAMGLILENERFIILSDILGIEDALGDMDFKVTGDQNGITAFQMDIKVEGITIEIMRVALKQAKEGRVHILNKMLAVCPTYKGEMSRYAPRIETIQIKPSKIAVVIGPGGKQIRAIIEQTGVQIDIDDTGLVNIAAIDLVSIEKAKAIIHGLTAEIEIGRIYSGKAISIAPFGVFVEILPGKEGLCHISEFDVNRINSLDEFVKQGDMLMVKVLDINERGQIKLSRKATLQSQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_STRZT
Sequence: MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPVARELREGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CNGA2_HUMAN
Sequence: MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
What is the function of this protein?
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger.  The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
What are the official names of this protein?
Cyclic nucleotide-gated olfactory channel, Cyclic nucleotide-gated cation channel 2, Cyclic nucleotide-gated channel alpha-2, CNG channel alpha-2, CNG-2, CNG2.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COX2_PARDE
Sequence: MMAIATKRRGVAAVMSLGVATMTAVPALAQDVLGDLPVIGKPVNGGMNFQPASSPLAHDQQWLDHFVLYIITAVTIFVCLLLLICIVRFNRRANPVPARFTHNTPIEVIWTLVPVLILVAIGAFSLPILFRSQEMPNDPDLVIKAIGHQWYWSYEYPNDGVAFDALMLEKEALADAGYSEDEYLLATDNPVVVPVGKKVLVQVTATDVIHAWTIPAFAVKQDAVPGRIAQLWFSVDQEGVYFGQCSELCGINHAYMPIVVKAVSQEKYEAWLAGAKEEFAADASDYLPASPVKLASAE
What is the function of this protein?
Subunits I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II, Oxidase aa(3) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EXP8_STRPN
Sequence: MQNKQEQWTVLKRLMSYLKPYGLLTFLALSFLLATTVIKSVIPLVASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAFANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVLDFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFNQEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLMAYFGYRGFSIGITVGTMYAFIQYINRLFDPLIEVTQNFSTLQTAMVSAGRVFALIDERTYEPLQENGQAKVQEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYEFQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQETSDEQVQAAAAFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLALGGTYHKMYSLQAGAMADTL
What are the official names of this protein?
Putative ABC transporter ATP-binding protein exp8, Exported protein 8.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUB_CALS8
Sequence: MNGILLVDKPVGLTSHDVVEYVRKLFKTKVGHCGTLDPFASGLLVLLIGEATKLSSFFTQTKKTYIATMQFGIKTDTLDITGKVQLRNNIFIEQNEIEDCLKDLKGEVELSVPIYSAKKVKGRKLYEYAREGIDIEIPKIKSIIYSIEMINYCYPYMTFKVECSHGTYIRSLAEEIAKKLSTVATLVQLRRAKNGVFDIKAAFSLDFISEDSIIPLENLILNEIIVNESVYKKLINGNPLTRKDIKEIRLNDSLFEDFYKISMKDAFFVYKREGDKFKYLLKVENYR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RS13_CHLPM
Sequence: MRIAGVNLPLNKHAVIALTHVYGIGKTTAKTILQRTGIAPDRKISDLNDAEAHSIRELIAEEYKVEGQARGEQQLSIKRLMDVGCYRGLRHRRSLPVRGQNTQTNARTRKGKRKTVAGKKKAARK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: IPO8_HUMAN
Sequence: MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKHDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRTVPPETLHIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQMELFLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDKEMPVKVEAALALQSLISNQIQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEITQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHSISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTDTLLSNAKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEEISSDEEETNVTAQAMQSNNGRGEDEEEEDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALITVQSRDAAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTVPSNN
What is the function of this protein?
Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1.  Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382).  In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607).  May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable).
What are the official names of this protein?
Importin-8, Imp8, Ran-binding protein 8, RanBP8.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GMT2_YEAS2
Sequence: MIYTSSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGKVTSMELTSFIMMVLSSVVATWGDQQAIAIKASSLEDLDQELVESTIFVLNPGYLWMFTNCISSALFVLIMRKRIRLTNFKDYDTMFYNNVLALPLLLVFSFIMEDWSTKNLSVNLSADSLAAMVISGLMSVGISYCSGWCVRVTSSTTYSMVGALNKLPIALAGLVFFDAPKNFLSFFSIFLGFLSGLLYAVAKQKKIQQQKVLAATLEK
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
Probable GDP-mannose transporter 2, GMT 2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Recycles between the Golgi apparatus and the endoplasmic reticulum.
Protein: RS4_SHEWM
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDSKCKLETAPGQHGARKTRLSEYGVQLREKQKVRRTYGVLEKQFRNYYKDAARTKGNTGENLLTLLETRLDNVVYRMGFGATRAEARQLVSHKSIMVNGSVVNIPSFKVSANDVISIREKSKKQARIIAALEVSSQREKPTWVEVDNTKMEGAFKRLPERSDLSAEINEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SCAP_SCHPO
Sequence: MRIFTLGKGRISRGYARQVNPSLFAKYSYCIANNPWYFILVFTLLSITGIYSSLVAYQQSLYDQSLARWSAWYAESINAEANVITKQLYLLGTNTSVFSEDYLSNAYRWETSFHQYLAEYGYPCIRDEKSCVTISPIPKYYGKVDPVAQYSYTKGLPENEREVNKLRNDTIAEGFDSLSAFVITYFLKPEQVDTFHVVLKKFISETPNLYASLLDTSPTTVVARIPDLTVIYRWYLWVGFGVGLFAYLYLSLVRLHDIRAKFGLTATIFIQSGTAYFSTCSLLYFFERTGPICPWPMAYYIIIFMDIENSFRLLRAVIASPQTKRVPSRIMEGFSSTIIASFSSLLKKLLTLFVLSFFVYPLVQEFCLFLACSFVVSFLLHGSFFLAVLSVDIRRLELQDFLDSNSSNRNSKWWVPYLEYVRFMWSPWIIDNLGTVSFHMYVIYLQLQSSTDINGSWRLASPNIRFLITLYHRLGRILRERKLFPLITTGWFGDPTFLEALKEKTMAENLVIALYRPVILDTVNRRDYTNVYNSFHDRRVWRWSTFFSILFAIDFAVGLLVKALLRGWSDHDELSTDTTLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVESPCLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVESSGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISIVSPTANRIACLTESGEVTVYSKKGPVWSPKILSQNKNYLTETKKDIYGIAMADILFLARDSGVDMIDLKNDELLHSFTLPPIKVNTFSVGVSNSRFVNGQFRVSSISFCFTHAVTEKVLYYYYGNECNESYIILNKWDQQPNLVDVHDPDNSLACLTFDELQENIHEVEDASECVMSSDGLYIFGMRRKSSSGICPTADEKNEDNGFTLRNRKLRTGHYNWTSYVPLLDSYMQDMEHKKNTHSGGETQVWEVWMYSQSEKKHRCKSLKMYNSLIIADPGPSLAVSDRCVAIVLGNYVALVGYGSEIFRDFYQIRNSDEMDRILRRKRKNLQRKRSGTIGC
What is the function of this protein?
Escort protein required for sre1 processing at low sterol as well as oxygen levels.  May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels (PubMed:15797383, PubMed:17595166).  4-methyl sterols bound to scp1 may mask an ER export signal in scp1 leading to retention of the complex in the ER (PubMed:15797383, PubMed:17595166).  Release of 4-methyl sterols may trigger a conformational change in the SSD domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth (By similarity).  Binds 4-methyl sterols (PubMed:17595166).
What are the official names of this protein?
Sterol regulatory element-binding protein cleavage-activating protein, SCAP, SREBP cleavage-activating protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SCAP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.