PharMolix/UniProtQA huggingface dataset:
Protein: ARNA_ECO57
Sequence: MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDNVNHPLWVERIAQLSPEVIFSFYYRHLICDEILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRVAIAPDDIAITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHHCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: DAPH_BACCQ
Sequence: MKMMDANEIISFIQKSEKKTPVKVYIKGDLKEVTFPETVQAFVNKKSGVLFGEWSEIKTILDENSKYIVDYVVENDRRNSAIPMLDLKGIKARIEPGAIIRDHVEIGDNAVIMMNATINIGAVIGEGSMIDMNAVLGGRATVGKNCHVGAGAVLAGVIEPPSAKPVIVEDDVVIGANVVVLEGVTVGKGAVVAAGAVVTEDVPPYTVVAGTPARVIKEIDEKTKAKTEIKQELRQLNPEK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: GLUC_COREF
Sequence: MSTLWADLGPSLLPAFWVTIQLTVYSAIGSMILGTILTAMRVSPVKILRSISTAYINTVRNTPLTLVILFCSFGLYQNLGLTLAGRDSSTFLADNNFRLAVLGFILYTSAFVAESLRSGINTVHFGQAEAARSLGLGFSDIFRSIIFPQAVRAAIIPLGNTLIALTKNTTIASVIGVGEASLLMKSTIENHANMLFVVFAIFAVGFMILTLPMGLGLGKLAEKMAVKK
What is the function of this protein?
Part of the ABC transporter complex GluABCD involved in glutamate uptake.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutamate transport system permease protein GluC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YHBP_ECOBW
Sequence: METLIAISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAVAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKMIWLRDSGTEQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: PSBN_NYMOD
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ARGC_BRUA4
Sequence: MKPKIFIDGEHGTTGLQIRTRLAERDDLEVISIPEAERRNKDLRADYLRAADIAILCLPDDASKEAVSLLEGHNSTRIIDTSTAHRVHPDWAYGFAELAKGQRERIAEARLVANPGCYPTGAIALVRPLRDAGLLPADYPVSVNAVSGYTGGGKQMIAQMEDKSHPEHLAANNFLYGLPLKHKHVPELQLHGRLDRRPIFSPSVGRFPQGMIVQVPLFLTGLEGTPSLAKVHSVLTDHYAGQDIVEVAPLEESAKLARVDAEELAGKDGMKLFVFGTEGDGEVNLVALLDNLGKGASGAAVQNMNLMLGKV
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPW_SCHPO
Sequence: MSYPKARIRRFFRQHCQRSLESSALDLVYLDYCLFLQSLLKEANIEAAKTGERRVQPEHVRSIQRKILAQFKG
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit wip1, CENP-W homolog, Constitutive centromere-associated network protein wip1, Histone-fold domain-containing protein new1.
What is the protein family that this protein belongs to?
Belongs to the CENP-W/WIP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore.
Protein: CA200_HUMAN
Sequence: MPSQSACPVLSTAPGTPCDLRKHLLNMVSEEKRSPQLSAKTWRRGLRLQKRRNALFLPEGDICVVGSTSGARALIPETSKLERSGTVIAYCNLELLASSDPPVWASQSTGMTGMSYRSQPQLGFKSTPPAHSSVFHHSVKAPKEDQAQEAASRPLTSQDGWNPNIKK
What are the official names of this protein?
Putative uncharacterized protein PIK3CD-AS1, PIK3CD antisense RNA 1, PIK3CD antisense gene protein 1.
Protein: IDI2_METKA
Sequence: MRERKWEHVLACIWEDVESEESPLFDCVKIVHRALPELDFDDVDMEIELFGKRLSFPLIIAGMTGGHPKTGEINRKLARVARELEIGIGVGSQRAGVKDPEVRWTFEVVREEYPDGLVLANIGLPQLRENGPDLALEVVDMVDADALAVHVNVLQEAVQLEGEADAAGFVDVLAEVCETVDVPVVLKETGAGVSAEDAKLVRDIVDGIDVGGAGGTNWAVVEAVRSKAHGEIPLGYAFSDWGVPTAASILEVRSVVGNDLAIIGTGGVRTGMDVAKVLALGADCAGMALPVLRKVLAEGVRGCVRFLKSIAREVKIAMLMAGCSSVEEMSSVPIVVYGKLREWLECRGVPLDLVCTGDRRTGWNR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SULA_YERPB
Sequence: MRTQSLKPYHANYHSLTTNDSPTRVDAPTDSGLISEFVYSENQPVVTQLLLPLLQQLSKQSRWLLWLTPQQKLSRSWLKQSGLPINKVVQLRQINPLSTVEAMEKALLTGNYSVVLGWLPELTEDDRIRLRLAAKLGNAYGFVMRPLNDTKVGSGQCATLKIHSYLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: TX72C_SCOMU
Sequence: MLVFYAPLFVSIFSNTVMGATIDKPIPKPILREAIEKIAVNKRADSRYCKEEKCPPGKHCPKVPIVCVRGPCCF
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Kappa-scoloptoxin(07)-Ssm2c, Kappa-SLPTX(07)-Ssm2c, Kappa-scoloptoxin-Ssm2c, Kappa-SLPTX-Ssm2c.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-07 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLME_METFK
Sequence: MKRRPTSKAWLQEHVNDEFVKRAQRDGYRARAAYKLLEIDDKDQLIKPGMTIVDLGSAPGSWSQVAVQRLAGQGRVIALDILEMPPIPGVEFIQGDFREEEILLVLEKSLNGKPVDLVIADMAPNISGISDVDQARAAYLVELALEFSREWLKPGGNFLVKVFVGSGFDEIVMAMRDSFEKVVTRKPKASRDRSSEVYLLGLKRRNA
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBP_CHICK
Sequence: MASQKRSSFRHGSKMASASTTDHARHGSPRHRDSGLLDSLGRFFGGDRHVPRRGFGKDIHAARASHVGSIPQRSQHGRPGDDNPVVHFFKNIVSPRTPPPMQAKGRGLSLTRFSWGGEGHKPGYGSGKFYEHKSAHKGHKGSYHEGQGTLSKIFKLGGSGSRPGSRSGSPVARR
What is the function of this protein?
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS.  Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers.  Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
What are the official names of this protein?
Myelin basic protein, MBP.
What is the protein family that this protein belongs to?
Belongs to the myelin basic protein family.
What are the subcellular locations of this protein?
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Protein: CER16_ARATH
Sequence: MDSKSLAKSKRAHTLHHSKKSHSVHKPKVPGVSEKNPEKLQGNQTKSPVQSRRVSALPSNWDRYDDELDAAEDSSISLHSDVIVPKSKGADYLHLISEAQAESNSKIENNLDCLSSLDDLLHDEFSRVVGSMISARGEGILSWMEDDNFVVEEDGSGSYQEPGFLSLNLNVLAKTLENVDLHERLYIDPDLLPLPELNTSQTKVSRNEEPSHSHIAQNDPIVVPGESSVREAESLDQVKDILILTDESEKSSAIEADLDLLLNSFSEAHTQPNPVASASGKSSAFETELDSLLKSHSSTEQFNKPGNPSDQKIHMTGFNDVLDDLLESTPVSIIPQSNQTSSKVLDDFDSWLDTI
What is the function of this protein?
Together with RST1, acts as cofactor of the cytoplasmic exosome and connects the cytosolic RNA exosome to the SKI complex (PubMed:31455787).  Acts as post-transcriptional gene silencing (PTGS) suppressor (PubMed:31455787, PubMed:31941670).  CER16/RIPR can, like RST1 suppress the production of small interfering RNAs (siRNAs) from the CER3 locus, which is involved in cuticule membrane and wax production, and in the typhine and sporopollenin biosynthesis of pollen (PubMed:31455787, PubMed:31941670).
What are the official names of this protein?
Protein ECERIFERUM 16, RST1-intearcting protein.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum.
Protein: AMPG1_RICBR
Sequence: MSRSLSIIWLFGLISGFNIMITGNTLNYWLAKENIALQTIGLLSLITLPYSINFLFAPIFDSLKIKYLDKIFGHRLSWICLTSIALVFFVYILSFLNPFDNLLLFASISLIISFFSSMQDTILSAFRTEIVNKESLGFASGIYIFGYRFGMLLANSGAIYLSIYLTFNEIYKIFAILIFIYLILLIVGVKYCRFDQNNDIEQTTNNNDDIFAFIKNILKPIGSISFIILILIFLILYRLPDNFINVMINPFLLHLNYDAFEIASVGKFWGVMGAIVGGLLGGFIMKKKNILDSILLFGIIHALAHILFIILKIHGKNSTLLFITIGAESITGGMTMTAYIAFISSLCQGKFRATQYSFFSSMMGISRSIFPIISGYIVVNFGWQNFFLFTTIITIPSLLVLLKIKNKLQQ
What are the official names of this protein?
Putative transporter AmpG 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HOME1_RAT
Sequence: MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPAQNALPFSHSAGDRTQGLSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELSQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSELEQRLEKSQSEQDAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
What is the function of this protein?
Postsynaptic density scaffolding protein.  Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.  By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.  May also couple GRM1 to PI3 kinase through its interaction with AGAP2.  Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2.  Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites.  Isoform 1 regulates the trafficking and surface expression of GRM5.  Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function.  Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.  Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (PubMed:19345194).  Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway.  Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
What are the official names of this protein?
Homer protein homolog 1, PSD-Zip45, VASP/Ena-related gene up-regulated during seizure and LTP 1, Vesl-1.
What is the protein family that this protein belongs to?
Belongs to the Homer family.
What are the subcellular locations of this protein?
Cytoplasm. Postsynaptic density. Synapse. Cell projection, dendritic spine. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
Protein: ACTL8_HUMAN
Sequence: MAARTVIIDHGSGFLKAGTAGWNEPQMVFPNIVNYLPCKENPGPSYARRRVSLGIDICHPDTFSYPIERGRILNWEGVQYLWSFVLENHRREQEVPPVIITETPLREPADRKKMLEILFELLHVPSVLLADQLQMSLYASGLLTGVVVDSGYGLTRVQPFHQGRPLPASGKTLEFAGQDLSAYLLKSLFKEDCDRRCLFQLETVAVTQMNKCYVPQNLGEALDFRERQQSALDESNTYQLPDGSRVELTPMQRVAPEMFFSPQVFEQPGPSIPRAIVESVESCEISLRPLLVSHVMACGGNTLYPGFTKRLFRELMGDHVSSTKATVWEGSNRNFSVWLGASVVAHLSTYQSEWMSREEYGEHMRM
What are the official names of this protein?
Actin-like protein 8, Cancer/testis antigen 57, CT57.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MS4A5_HUMAN
Sequence: MDSSTAHSPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRFPFIFLSGYPFWGSVLFINSGAFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFILDQNYICGYSHQNSQCKAVTVLFLGILITLMTFSIIELFISLPFSILGCHSEDCDCEQCC
What is the function of this protein?
May be involved in signal transduction as a component of a multimeric receptor complex.
What are the official names of this protein?
Membrane-spanning 4-domains subfamily A member 5, CD20 antigen-like 2, Testis-expressed transmembrane protein 4.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: THIG_SHEFN
Sequence: MLTIADHQFSSRLLTGTGKFSNHNTMLQAIASSGSQLVTLAMKRIDLTRGHDNLLGPLQSMGVKLLPNTAGARNAKEAIFAAELAYEMLGTKWIKLEIHPDPKYLMPDPIETLIAAQHLCEKGYIVMPYVHADPVLCRRLEEVGCAAVMPLGSPIGSNQGLATETFLSIIIEQANIPVIVDAGIGAPSQACRAMEMGAAAVLVNTAIASSANPQQMAKCFADAVATGRQAYLAGLGAVNNHAHATSPLTGFLSEPSISSLAKSVNSKGG
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI4KB_OTOGA
Sequence: MGDTVVEPTPLKPTSESTPGPAGSNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSRNSPLELVNGDGVDNEIRCLDDPPSRIREEEDEMGATVAVGTAKGARRQRQNNSAKQSWLLRLFESKLFDISMAMSYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).  May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity).  Involved in Golgi-to-plasma membrane trafficking (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment.
Protein: CASP6_MOUSE
Sequence: MTETDGFYKSREVFDPAEQYKMDHKRRGVALIFNHERFFWHLTLPERRGTNADRDNLTRRFSDLGFEVKCFNDLRAEELLLKIHEVSTSSHIDADCFICVFLSHGEGNHVYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDMVDHQTDKLDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLARYGSSLEFTELLTLVNRKVSQRRVDFCKDPDAIGKKQVPCFASMLTKKLHFCPKPSK
What is the function of this protein?
(Microbial infection) Proteolytically cleaves the N protein of coronoviruses.  The cleavage leads to two fragments and modulates coronavirus replication by regulating IFN signaling.  The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes.
What are the official names of this protein?
Caspase-6, CASP-6, Apoptotic protease Mch-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BRO1_GIBZE
Sequence: MAQSPMISVPLKATNEIDWVEPLKRYIRDTYGDDPERYAEECATLNRLRQDVRGAGKDSTSGRDMLYRYYGQLELLDLRFPVDEQHIKISFTWFDAFTHKSTAQYSLAFEKASIIFNISAVLSCHAAAQDRGEESALKTAYHNFQASAGMFTYINENFLHAPSSDLSRETVKALIHVMLAQAQEVFLEKQVADKKKPALLAKLASQAGYLYSQALEGVQENVTKAIFEKVWLLMTQIKSNLLNSMAQYYQALADEEQDKHGIAVGRLQTAETQAKEAERVARSFPNSVPMSSNLSADCGGFLQELTKRHLSTVQSQLQSALKDNDYIYHKEVPAEASLEAVAKLPAAKPIPVSELYAGQDIQRITGPDLFAKIVPFAVTESASLYDEEKAKLVRAEAERVDTANGEMAASLDYLRLPGALQVLKGGFDQDILPDEDFRQWCEDVSDQENPVTLFDSLRTEKDSILSILDKSTKQLDMEEGVCEKMRSKYENEWTQQPSSRLTTTLRGDIRHYREALDEASRSDNQLAGKLRQNEMDFDEMRRAAKSGEADQLFQRAVAQARARGSNATSPAGLEPNLLDDDFDEGPSVIDQINRVEDILKKLNSIKRERNQVLKDLKEKAHNDDISQILILNKKSISNYEAQLFEQELEKFRPHQNRLLQANHKQSALMKELTSAFNRLLQDKRVQSEQSKYETIQRQRSSVINRYKRAYQEFLDLVAGLQSAKNWYAEMRETVESLEKNVDSFVNNRRSEGAQLLNQIEQERSSNKNSQAEMERERLRGLMDRMSMDPNKSSPQPQQNRPTPPSQYQQSQAPRYPQTNYQGQYQQPNSPPPQQAQQQAYQNFSPPPTTTTTQSFGPPPINTFVQPTYNPSQYGRTPGPTSPPPNQTSFNIGGYRGPASPPPNQSTFGQSQSFGGYGASSTPQTQGGYVPPGFVPPPPPPGPPPLGPQQTFHYGNQPNSAHPNSAYPQSAMPPQQQQQQQQQQQNDPWAGLNAWK
What is the function of this protein?
Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.
What are the official names of this protein?
Vacuolar protein-sorting protein BRO1, BRO domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the BRO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome.
Protein: RNZ_CHLTB
Sequence: MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNLDRVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVIEHPIDREGIVEDFGNFRIESRQLDHLVDTLGWRITEPDTTKFIPEKIKAAGLKGPIMQELINKGRVKVNDTIVHLDDVSYTRKGDSIAVVADSLPCQAIVDLARNARILLCESTYLEEHSHLAKSHYHMTAKQAAEQAKRAEVQQLILTHFSARYNTTEEFVQEAGEIFPNVFAAEEFCSYEFPKNPS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: YWBB_BACSU
Sequence: MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRKNDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLAEVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEANLRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDESTYISWYR
What are the official names of this protein?
Uncharacterized protein YwbB.
Protein: HMLL_DROME
Sequence: MNDLKPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQVGKESFVSYLPLSHVAAQIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMSETSGAITLNVDISNLYSAGQACEGVTLKIHEPDCNGQGEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLYK
What is the function of this protein?
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:26893370, PubMed:29739804).  Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104).
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase heimdall, Very long-chain-fatty-acid--CoA ligase double bubble.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
Protein: CAPP_THEVL
Sequence: MTSVLDVTNRDRLIESESLAARTLQERLRLVEEVLVDVLAAESGQELVDLLRRLGALSSPEGHVLHAPEGELLKVIESLELNEAIRAARAFNLYFQIINIVEQHYEQQYNRERAAQEGLRRRSVMSEPISGVSGEGFPLPHTAANATDVRSGPSERLEHSLYEAIPATQQYGSFAWLFPRLQMLNVPPRHIQKLLDQLDIKLVFTAHPTEIVRQTIRDKQRRVARLLEQLDVLEGASPHLTDWNAQTLRAQLMEEIRLWWRTDELHQFKPEVLDEVEYTLHYFKEVIFAVIPKLYRRLEQSLHETFPALQPPRHRFCRFGSWVGGDRDGNPYVKPEVTWQTACYQRNLVLEEYIKSVERLINLLSLSLHWCDVLPDLLDSLEQDQRQLPSIYEQYAVRYRQEPYRLKLAYVLKRLQNTRDRNRALQTYCIRRNEAEELNNGQFYRHGEEFLAELLLIQRNLKETGLACRELDDLICQVEVFGFNLAALDIRQESTCHAEALNEITAYLGILPCPYTELSEAERTRWLLSELSTRRPLIPGELPFSDRTNEIIETFRMVRQLQQEFGTDLCNTYIISMSHEVSDLLEVLLFAKEAGLFDPATGASTLQAIPLFETVEDLKHAPAVLTQLFSLPFCRSYLGSNSTPFLQEVMLGYSDSNKDSGFLSSNWEIYKAQQQLQKIAESFGFQLRIFHGRGGSVGRGGGPAYAAILAQPAQTIKGRIKITEQGEVLASKYSLPELALFNLETVATAVIQASLLRSSIDEIEPWHEIMEELATRSRQCYRHLIYEQPEFIEFFNEVTPIQEISQLQISSRPTRRGGKKTLESLRAIPWVFSWTQTRFLLPAWYGVGTALKEFLEEKPAEHLSLLRYFYYKWPFFRMVISKVEMTLAKVDLEIARYYVQELSQPQNREAFCRLYDQIAQEYRLTTELVLTITGHERLLDGDPALQRSVQLRNRTIVPLGFLQVSLLKRLRQHNSQTTSGAILRSRYGRGELLRGALLTINGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.