PharMolix/UniProtQA huggingface dataset:
Protein: KGX11_CENNO
Sequence: MKVLILIMIIASLMIMGVEMDRDSCVDKSRCAKYGYYQECQDCCKNAGHNGGTCMFFKCKCA
What is the function of this protein?
Blocks human and rat Kv11. 1/KCNH2/ERG1 and Kv11. 3/KCNH7/ERG3, as well as rat (but not human) Kv11. 2/KCNH6/ERG2 (PubMed:11755529, PubMed:11864985, PubMed:16497878, PubMed:17369411, PubMed:20600425) by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry (PubMed:11755529, PubMed:11864985, PubMed:17369411, PubMed:20600425).  Inhibition data are the following: hERG1 (reversible, IC(50)~7 nM) (PubMed:11755529, PubMed:11864985, PubMed:16497878, PubMed:17369411, PubMed:20600425), rERG1 (reversible, Kd=6. 8 nM) (PubMed:16497878), rERG2 (irreversible, Kd=2. 8 nM) (PubMed:16497878), hERG3 (irreversible, Kd=4. 05 nM) (PubMed:16497878) and rERG3 (reversible, Kd=38. 1 nM) (PubMed:16497878) potassium channels.  The toxin potency is not affected by elevating potassium ion concentration from 2 to 98 mM (PubMed:11864985).  This toxin only blocks channels in a closed state (PubMed:12860380).  At high toxin concentrations, block of Kv11. 1/KCNH2/ERG1 macroscopic current is incomplete (93. 5%).  This suggests a kinetic mechanism model with two different states of toxin-channel binding (T+C=TC*=TC; in the TC* state, the toxin binds the channel but does not occlude the pore, whereas in the TC state the toxin binds and occludes the pore).  In this model, incomplete block is explained by the relatively fast dissociation rate from the blocked channel conformation (TC) relative to the rate of conversion of the toxin-channel encounter complex (TC*) to the blocked channel conformation (TC) (PubMed:17369411).
What are the official names of this protein?
Potassium channel toxin gamma-KTx 1.1, Ergtoxin, CnErg1, CnErgTx1, ErgTx, ErgTx1.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COBQ_PROM3
Sequence: MSTDGMSTPLMVLGTSSGAGKSLMSAALCRLLLRRGETPIPFKGQNMSNNAWVDESGGEMAYSQALQAWAAGLKPQCAMNPVLLKPQGDSTSEVIHLGQSVGTARAETYYEQWFRPGWSVIREALKDLQCSYTHGRLVLEGAGSPVEVNLQRRDLTNLRLAQFLRARCLLVADIERGGVFAQIIGTLSLLKPVEKQLIRGLLINRFRGRRELFDEGRDWLEAETGIPVIGVMPWLEELFPPEDSLDLLERRGKKNDAEIEIAVLKLPSLSNFSDLDPLEAEPTVQLRWVEPGTFLGTPDAVIIPGSKQTLRDLNSLNRSGLGSQLQTYAQSGGHVFGICGGMQMLGRTLADPLGLEGVTTTDPSSSMAGLNLLPLDTVFKRSKALKQCQRITQWPDNAKVKGFELHHGNSQLIQGSHESVLPMADDPSLGWVSKNERCGQVAGTYLHGIFENGRWRRLWLNLIRKQKGLADLPTDIPHHEQQREQLLNRLTDVFEEHVNINPLLGT
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: HMUV_PSEPK
Sequence: MLQVEGLYLCRGSNEVLHDIHLQLPPGQVVGVLGPNGAGKSSLLSVLCGELAPDRGRVTLQGRPLADWAGQERARRLAVLPQVSSLGFSFRVEEVVGMGRMPHGTGQRRDAEIVEAALRAADAWHLVARSYLALSGGERQRVHLARVLAQLWPGEEGSTLLLDEPTSMLDPLHQHTTLEAVRRFADCGAAVLVILHDLNLAARYCDRILLLEQGRCHAFATPEAALTPAALKAVYGIDVLVQAHPERGHPLIITR
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PUR1_RAT
Sequence: MELEESGIREECGVFGCIASGDWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPKFRVHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPAAYSLVIMHRDVIYAVRDPYGNRPLCIGRLMPVSDINDKEKKSSETEGWVVSSESCSFLSIGARYCHEVKPGEIVEISRHGVRTLDIIPRSNGDPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAVEAPVEADLVSTVPESATPAALGYATKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLIDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKHPCFMGINIPTKEELIANKPEFEYLAEYLGANSVVYLSVEGLVSSVQQEIKFKKQKVKKRDITIQENGNGLEYFEKTGHCTACLTGQYPVDLEW
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: NADB_NEIMB
Sequence: MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIEKHVADTLEAGAGLCDEAAVRAILSQGKPAIEWLLAQGVAFDRNHNGLHLTREGGHTCRRIAHVADYTGEAVMQSLIAQIRRRPNIRVCERQMALDIQTESGAACGLTVLDCRTQETYRIRARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVGNLEFIQFHPTGLARPSENGRTFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTQDFVSLDISHQPAAFVRRHFPSIHRHCLSQCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYALGETACTGLHGANRLASNSLLECVVTARLCAQAIADGQAFQAEPFQRPSESLSAEAGIFSDDLQNTFSRPVLQTFNQRHLGILRNDTGLRRAIAQLQLWKQNQAEPHTASEYENRNLLECSLAVAQAAYRRRQNIGAHFNSDC
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_ECO81
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLIKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD18_HUMAN
Sequence: MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVREIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRAAESAEIEPRNKRNRN
What is the function of this protein?
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA.  Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.  Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'.  Has ssDNA binding activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase RAD18, Postreplication repair protein RAD18, hHR18, hRAD18, RING finger protein 73, RING-type E3 ubiquitin transferase RAD18.
What is the protein family that this protein belongs to?
Belongs to the RAD18 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1- SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
Protein: RRG9_YEAS7
Sequence: MNILRIACRSFHCLRCGPLLNENRGWSSKKIIKLVNKSSLSNKEFTEKVRDGTKDIPEWKKQKMAVRKKLQGQRWNPPKKISQEQMEALRLLKFNFPELTASDLADRFKISPEAVRRILKSNWKRTDEENNNTYERWKRRGERIKEMYQRKEDADFVSNQIVTSRKIILGSNSNSPELIARNVRTFKPFKPNNSTPEKKNTNKLYILKHLGSKQ
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
Protein: BIOB_STRM5
Sequence: MAAAIRHDWQHDELQALFDLPFPELLFRAAAVHREHFDPAQVQVSTLLSVKTGGCPEDCAYCPQAQRYNTGVNAQKLMETDAVLAKARQAKAAGASRFCMGAAWRSPKDRDIPKVAAMIAGVKALGLETCATLGMLSGGQARALKDAGLDYYNHNLDTAPDYYDSIIHTRQYQDRLDTLEHVRDAGLKTCCGGIVGMGETRAQRVGLLLALATLPAHPDSVPINKLVQVAGTPLHGSAELDPFEFVRMIAVARIVMPRSMVRLSAGREAMSDELQALCFVAGANSIFYGDKLLTTGNPESERDLALFARLGLQPMAVQVDAEGHDHGGTVHADISADAPGCGCAHAA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GALK1_ARATH
Sequence: MAKPEEVSVPIFTSLEPVYGEGSLLQEATQRFDVLKANFNDVFGASPQLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIIAIRKCEDQKQLRIANVNDKYTMCTYPADPDQEIDLKNHKWGHYFICAYKGFHEYAKSKGVNLGSPVGLDVLVDGIVPTGSGLSSSAAFVCSATIAIMAVFGHNFEKKELAQLTCECERHIGTQSGGMDQAISIMAKTGFAELIDFNPVRATDVKLPDGGSFVIAHSLAESQKAVTAAKNYNNRVVECRLASIILGVKLGMEPKEAISKVKTLSDVEGLCVSFAGDRGSSDPLLAVKEYLKEEPYTAEEIEKILEEKLPSIVNNDPTSLAVLNAATHFKLHQRAAHVYSEARRVHGFKDTVNSNLSDEEKLKKLGDLMNESHYSCSVLYECSCPELEELVQVCKENGALGARLTGAGWGGCAVALVKEFDVTQFIPAVKEKYYKKRVEKGVVKKEDMELYLFASKPSSGAAIFNL
What is the function of this protein?
Sugar-1-kinase with a very high substrate specificity for the alpha-anomeric configuration of D-galacose (D-Gal).  Converts also efficiently 2-deoxy-D-Gal to 2-deoxy-D-al-1-phosphate.
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
Protein: LSRA_YERP3
Sequence: MPHTVATPPPLLQVRGISKQFSGVVVLKSIDFTLQPGQVHALLGGNGAGKSTLMKIIAGILPPDTGVIEMNGQPCFNLTPAKAHQLGIYLVPQEPMLFANLSVQENILFRLPKHQADKKKMAQLLKNLGCHLDLSVSAGSLEVADQQLVEIMRGLMRDSRILILDEPTASLTPAETHRLFSQIRILLQQGVGVVFISHKLPEIRQLADWVSVMRDGGIALSGATADFSTEDMIQAMTPEAQKGALTDSQKLWLELPGNRRAQSRAQSQQPVIHVHDLSGEGFAHISFHVQAGEILGLAGVVGAGRTELAETLYGLRPASTGNVILEEVNITAMKTANRLAAGLVYLPEDRQASGLYLDAPLSWNVCALAHDRQGLWTQPAQEAAVLERYRRALNIKFSHLEQPVRTLSGGNQQKLLIAKCLEANPLLLIIDEPTRGVDVSARSDIYQLIRSIAEQQVAIIFISSDLEEVVQMADRVLVMHQGEINGALSGAAMNVDTIMHMAFGEHRSVSEPQGGTASSAENKGASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CAMK3_ARATH
Sequence: MGQCYGKVNQSKQNGEEEANTTTYVVSGDGNQIQPLTPVNYGRAKNTPARSSNPSPWPSPFPHGSASPLPSGVSPSPARTSTPRRFFRRPFPPPSPAKHIKASLIKRLGVKPKEGPIPEERGTEPEQSLDKSFGYGKNFGAKYELGKEVGRGHFGHTCSGRGKKGDIKDHPIAVKIISKAKMTTAIAIEDVRREVKLLKSLSGHKYLIKYYDACEDANNVYIVMELCDGGELLDRILARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSLEADIWSIGVITYILLCGSRPFWARTESGIFRTVLRTEPNYDDVPWPSCSSEGKDFVKRLLNKDYRKRMSAVQALTHPWLRDDSRVIPLDILIYKLVKAYLHATPLRRAALKALAKALTENELVYLRAQFMLLGPNKDGSVSLENFKTALMQNATDAMRESRVPEILHTMESLAYRKMYFEEFCAAAISIHQLEAVDAWEEIATAGFQHFETEGNRVITIEELARELNVGASAYGHLRDWVRSSDGKLSYLGFTKFLHGVTLRAAHARPR
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity).  Serine/threonine kinase that phosphorylates histone H3 an GLN1-1.
What are the official names of this protein?
CDPK-related kinase 3, AtCRK3, Calcium/calmodulin-dependent protein kinase 4, AtCK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side.
Protein: ISPT_LACLA
Sequence: MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVKFIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDSIDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQDLSLLTEEELSKHLQTAVLSENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRYGGVK
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: ALR_LEGPC
Sequence: MSRPTRLVIEPSALLHNLSQIKHLAPGKKVIAMVKANAYGCGVREVAPVLDGRIEAFGVACLEEALAIRALGVETPCILFQGVFSSDELSVAVENDFACVLHHAQQLEWLIKTPLPYPIKVWVKVNTGMHRLGFKIHELQKVMGALQTCTWVDKSIGLMTHLACADEPHRPENQQQISLFQEISIPGFRQRSIANSAAIISFPDSQADVVRPGIMLYGVSPFANQNAHDLGLIPVMRFMSAISAIHDNPSFAQVGYGGTWKSDKPSRIGVVAAGYGDGYPRHISEKTPVWVRGREVSIVGRVSMDMLTIDLTEHPDVEIGDEVELWGTHVLVERIAKSAGTVGYELLCQISERVRYK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: HPCL1_PONAB
Sequence: MGKQNSKLRPEVLQDLRENTEFTDHELQEWCKGFLKDCPTGHLTVDEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRSEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDPSIVRLLQCDPSSASQF
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
What are the official names of this protein?
Hippocalcin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: KTHY_ACIBT
Sequence: MFISFEGTEGVGKTTLIRKIHQHFEEQGKQVVLTREPGGTPLAEQIRSMLLAVNHDENMSHDTELLLIYAARAQHLQQVILPALESNKIVLSDRFTDASFAYQCSGRGLSQDKLQLLNQNFVSRMPEVTFWLDAPIELGMNRARERGALDRFEQEKLSFFTKVREGYETLWKVEPERIKRLDATQSPDQVFEQALQYLA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LEPA_PSEP1
Sequence: MSHIRNFSIIAHIDHGKSTLADRFIQMCGGLSAREMEAQVLDSMDLERERGITIKAHSVTLHYKAQDGKTYQLNFIDTPGHVDFTYEVSRSLAACEGALLVVDAGQGVEAQSVANCYTAIEQGLEVMPVLNKMDLPQADPDRVKDEIEKIIGIDATDAVACSAKSGMGVDEVLERLVHTIPAPEGEIDAPLQALIIDSWFDNYLGVVSLVRVRQGRVKKGDKILVKSTGKVHLVDSVGVFTPKHTQTADLKAGEVGFIIASIKDIHGAPVGDTLTLSSTPEVEVLPGFKKIQPQVYAGLFPVSSDDFEDFRDALQKLTLNDSSLQYMPESSDALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPSVIYELELKTGETIVVDNPSKLPDVSAVADFREPIVTATILVPQEHLGNVITLCIEKRGVQRDMQFLGSQVQVRYDMPMNEVVLDFFDRLKSTSRGYASLDYHFDRYQSANLVKLDVLINGDKVDALALIVHRDNAAYKGRALTEKMKELIPRQMFDVAIQAAIGGQIIARTTVKALRKNVLAKCYGGDVSRKKKLLEKQKAGKKRMKQVGNVEIPQEAFLAVLRLDS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MED10_YEAST
Sequence: MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPEATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II.  The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10, Negative regulator of URS2 protein 2.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_CYTH3
Sequence: MPYLFTSESVSEGHPDKVADQISDALIDHFLAFDPNAKVACETLVTTGQVVLAGEVKSKAYLDVQEIAREVIRKIGYTKSEYMFEANSCGIFSAIHEQSADINQGVDRKKKEEQGAGDQGMMFGYATNETNDYMPLALDLAHKLLIELAALRREGKQIKYLRPDAKSQVTLEYDDNNRPVRIDAIVLSTQHDDFDTEEKMHKKIEKDIVSILIPRIVSKYPKYKKFFDGKTKIKYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYATRHIAKNLVAAGLCDEVLVQVSYAIGVAKPMGIYVNTYGTAKVKKNDGEIAKIVEKLFDMRPYAIEQRLQLRNPIYSETAAYGHMGRKPETVTKSFKSNDGKIIKKKVELFTWEKLDYVDKVRKAFGIK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGG_SHIB3
Sequence: MMKMRWLSAAVMLTLYTSSSWAFSIDDVAKQAQSLAGKGYEAPKSNLPSVFRDMKYADYQQIQFNHDKAYWNNLKTPFKLEFYHQGMYFDTPVKINEVTATAVKRIKYSPDYFTFGDVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVIGAGQVYGLSARGLAIDTALPSGEEFPRFKEFWIERPKPTDKRLTIYALLDSPRATGAYKFVVMPGRDTVVDVQSKIYLRDKVGKLGVAPLTSMFLFGPNQPSPANNYRPELHDSNGLSIHAGNGEWIWRPLNNPKHLAVSSFSMENPQGFGLLQRGRDFSRFEDLDDRYDLRPSAWVTPKGEWGKGSVELVEIPTNDETNDNIVAYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAWVQQTRRSTGDVKQSNLIRQPDGTIAFVVDFTGAEMKKLPEDTPVTAQTSIGDNGEIVESTVRYNPVTKGWRLVMRVKVKDAKKTTEMRAALVNADQTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ATPD_SYNP1
Sequence: MQTTIRGELVEPYAEALLSLAQSHNLADQFQQDSGLILDLLAASAELQEFLANPLINPDAKKNVLRQLTVDKVHGYFLNFLMLLVDRRRINLLAAICQQYRALLRKLRNIVLAEVISAVELTEQQRHAVVEKVKTMTGAADVELAIAIDPELLGGVVIKVGSQIFDASLRGQLRRLSVSLAQPV
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: GUAA_ECOSE
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CLVS2_MACFA
Sequence: MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEYNVDSYSMPVKEVEKELSPKSMKRSQSVVDPTVLKRMDKNEEENMQPLLSLD
What is the function of this protein?
Required for normal morphology of late endosomes and/or lysosomes in neurons.  Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
What are the official names of this protein?
Clavesin-2, Retinaldehyde-binding protein 1-like 2.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: TRMD_STAS1
Sequence: MKIDFLTLFPEMFNGVLNQSILKRAQDKNMLTVNTVDFRHFAENKHNQVDDYPFGGGQGMVLKPEPIFNAMESIEKTDDTRVILMCPQGKPFTQAIANELSQSEHVVFICGHYEGYDERIREHLVTDEISMGDYVLTGGELPAMVMTDAIVRLLPGVLGNQQSHEDDSFQDGLLEFPQYTRPREYKGMSVPDVLLSGNHAHIDRWRHEQKILRTFVKRPDLLERYPMTVEEKDIVERYKKQLKKD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y263_MYCGE
Sequence: MKNEIKYLYSDLDGTIVSWNPKTEFVYQNKSYKNFHEVSDATISAFYRLQQKGIKVGIVTGRDYCRVLWLEKQLRTGLPTITLDGAIIFYQNEILSQTYLDDRFIEGINNIVKRFPEAAYKLNSGWISYFTKNPSVIFEIDYAFLGYFNPNTKLQKKFIDSTENWDLNKLKVNQVYFDIDTCPLAMQKEIIELISVSDVNAKIYEHSMYIIKNGVSKASALQSLNQFAIPITKDNTIVCGDGDNDIEMMQWAKHSVSLIGSNPKCFALAKYHTDSVDNDGIANWIEKNLLC
What are the official names of this protein?
Putative phosphatase MG263.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.