PharMolix/UniProtQA huggingface dataset:
Protein: NEP_I50A0
Sequence: MDPNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLEEAVMRLGDLHSFQNRNGKWREQLGQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: AHBA_DESDA
Sequence: MTTQTSAATGSPTQQNNAALADMDSMDRQLLDIIQTGFPLSPRPYAELGQRLGLDEQEVLDRVRGLKARKIIRRLGANFQSAKLGFVSTLCAAKVPQDKMDAFVAEVNAKPGVTHNYLREHDYNIWFTLISPSREETQAILDGITQATGVPILNLPATKLFKIRVDFRMDNDS
What is the function of this protein?
Involved in siroheme-dependent heme b biosynthesis.  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (PubMed:24865947).  Siroheme is decarboxylated to monodecarboxysiroheme, which is in turn decarboxylated to didecarboxysiroheme (PubMed:24865947).
What are the official names of this protein?
Siroheme decarboxylase alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.
Protein: CH601_SALRD
Sequence: MSKNPPDLSGGEVKAKQIRFDSDARSALQEGVDQMAEAVKVTLGPKGRNVVLEKSFGAPTITKDGVTVAKEIELEERLPNIGAQVLKEAASKTNDDAGDGTTTATVLAQSVINAGMKSVTSGANPMDVKRGITAAAEEVVTHLRNQSDPVEGKDRISQVATISANNDDAIGDLIADAFERVGQDGVITVEEARGIETYLDVVEGMQFDRGYLSPYFVTDSEEMEAVLEDAYILIYDDEVGNMQDLLPILEKVSQTSNPLLIIAEDVEGEALATLVVNKMRGTLKVSAVKAPGFGDRRQSMLEDIAVLTGGTVISEEKGYRLENATLDYLGQADRVTIDQDNTTIVGGEGSEEEIEARVNQIRQQIANSTSDYDQEKLQERLAKLAGGVAVLNVGAATEPEMKAQKALVEDALSATRAAVDEGVLPGGGVAYLRALESIEEVEVENEDQEIGVSIVREALEAPLRQIAENTGHEGSIVVQKVKDGEGDFGFNARTEEYGDLLDQGVLDPTKVTRSALENAASVGGMLLTTEAVIADLEDEDDDDGGGGGGGGMPAGGAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPD_SULAC
Sequence: MYLVEEAKKVAEMILSSVNAIAFTGAGISTASGIPDFRGPQGLWKKYSPELASIEYFQKYPDAFWQFYSTRMKSLFEAKPNRAHYALAQLEKMGLIKAVITQNVDGLHSVAGSRNVIELHGNMRKSYCTSCLRSYDSLEVLARVEKGEVIPRCECGGILKPDVVLFGEPVHGIYEAMRIANESDLVLAIGSSLTVYPANQIPLIVKRNGGGLIILNGEETPYDEYADLVIRERIEIFLPEVISHIQSLHRSS
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.  Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
What are the official names of this protein?
NAD-dependent protein deacetylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WR52R_ARATH
Sequence: MTNCEKDEEFVCISCVEEVRYSFVSHLSEALRRKGINNVVVDVDIDDLLFKESQAKIEKAGVSVMVLPGNCDPSEVWLDKFAKVLECQRNNKDQAVVSVLYGDSLLRDQWLSELDFRGLSRIHQSRKECSDSILVEEIVRDVYETHFYVGRIGIYSKLLEIENMVNKQPIGIRCVGIWGMPGIGKTTLAKAVFDQMSSAFDASCFIEDYDKSIHEKGLYCLLEEQLLPGNDATIMKLNSLRDRLNSKRVLVVLDDVCNALVAESFLEGFDWLGPGSLIIITSRDKQVFRLCGINQIYEVQGLNEKEARQLFLLSASIKEDMGEQNLHELSVRVISYANGNPLAISVYGRELKGKKKLSEMETAFLKLKRRPPFKIVDAFKSSYDTLSDNEKNIFLDIACFFQGENVNYVIQLLEGCGFFPHVEIDVLVDKCLVTISENRVWLHKLTQDIGREIINGETVQIERRRRLWEPWSIKYLLEYNEHKANGEPKTTFKRAQGSEEIEGLFLDTSNLRFDLQPSAFKNMLNLRLLKIYCSNPEVHPVINFPTGSLHSLPNELRLLHWENYPLKSLPQNFDPRHLVEINMPYSQLQKLWGGTKNLEMLRTIRLCHSQHLVDIDDLLKAENLEVIDLQGCTRLQNFPAAGRLLRLRVVNLSGCIKIKSVLEIPPNIEKLHLQGTGILALPVSTVKPNHRELVNFLTEIPGLSEASKLERLTSLLESNSSCQDLGKLICLELKDCSCLQSLPNMANLDLNVLDLSGCSSLNSIQGFPRFLKQLYLGGTAIREVPQLPQSLEILNAHGSCLRSLPNMANLEFLKVLDLSGCSELETIQGFPRNLKELYFAGTTLREVPQLPLSLEVLNAHGSDSEKLPMHYKFNNFFDLSQQVVNDFFLKALTYVKHIPRGYTQELINKAPTFSFSAPSHTNQNATFDLQPGSSVMTRLNHSWRNTLVGFGMLVEVAFPEDYCDATDVGISCVCRWSNKEGRSCRIERNFHCWAPGKVVPKVRKDHTFVFSDVNMRPSTGEGNDPDIWAGLVVFEFFPINQQTKCLNDRFTVTRCGVRVINVATGNTSLENISLVLSLDPVEVSGYEVLRVSYDDLQEMDKVLFLYIASLFNDEDVDFVAPLIAGIDLDVSSGLKVLADVSLISVSSNGEIVMHSLQRQMGKEILHGQSMLLSDCESSMTENLSDVPKKEKKHRESKVKKVVSIPAIDEGDLWTWRKYGQKDILGSRFPRGYYRCAYKFTHGCKATKQVQRSETDSNMLAITYLSEHNHPRPTKRKALADSTRSTSSSICSAITTSASSRVFQNKDEPNKPHLPSSSTPPGNAAVLFKMTDMEEFQDNMEVDNDVVDTRTLALFPEFQHQPEEEYPWSTFFDD
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.  Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R. solanacearum, P. syringae pv.  tomato and C. higginsianum.
What are the official names of this protein?
Disease resistance protein RRS1, Disease resistance protein RCH2, Probable WRKY transcription factor 52, Resistance to Colletotrichum higginsianum 2 protein, Resistance to Ralstonia solanacearum 1 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURQ_COREF
Sequence: MSAKIGVITFPGTLDDVDALRAVRIAGAEPVNLWHADEDLRGVDAVVVPGGFSYGDYLRTGAISALAPVMQSVIEAAGRGMPVLGICNGFQILTEARLLPGALTRNQGLHFHCVDTHLEVVNTDTAWTGTLEQGQKILVPAKHGEGRFQAEPDTIRMLEEEGRVVFRYTDNFNGSINGIAGITNETGRVVGLMPHPEHAVETLTGPSVDGLELFLSAIGTIAA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_HISS2
Sequence: MLKIFNTLTREKEVFKPISENKVGMYVCGVTVYDLCHIGHGRTFVCFDVIARYLRYLGYELTYVRNITDVDDKIIRRALENKETCEQLVDRMVVEMYKDFDALNVLRPDFEPRATHHIAEIIALVEKLIARGHAYVADNGDVMFDVESFKEYGKLSRQDLTQLQAGARVEISEIKKNPMDFVLWKMSKENEPSWNSPWGAGRPGWHIECSAMNCKHLGEHFDIHGGGADLMFPHHENEIAQSCCAHGNRYVNYWIHSGMIMVDKEKMSKSLGNFFTIRDVLNHYDAESVRYFLLTAHYRSQLNYSEENLDLAHGALERLYTALRGTDKSAVSFGGENFIAQFTEAMNDDFNTPNAISVLFEMAREINRLKNEDKLLADGLAARLRELASILGLLDQDPEDFLQAGSDDAEIAKIEELIKQRNDARQAKDWARADAARNELTTMGVILEDSSNGTMWRKM
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COWN_ARCNC
Sequence: MSNFEIRVNESYESFKNIDCFENACVVIDNMLRVLENPKNMNIYWKKIVPMIPKAYYDRDPKSDTKEELLYLVCSNSFYLDELFEKAEDEQAINALSKCEQECC
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.
Protein: HIS7_SPHAL
Sequence: MRTATVQRTTKETDIAITVNLDGTGDYSVSTGIGFLDHMVEQLSRHSLIDISMQVKGDLHIDQHHTVEDSALALGEAVAKALGDKRGIARYGEAHAPMDETLTRCVLDISGRPHCVYKSSFSQPRLGEMDTEMFPHWFHSFAQTAGITLHIETLYGENNHHIAESMYKALARALRQAVEIDPRKGDAIPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNT2_MOUSE
Sequence: MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPIPLNSGSTSVQDSRASDNLSVLAAGMPSTSYSLSSHQEWPQHPDSARTDPVYTQKQEATLSGSQYISFQQGPSMALHSGLHHRPDKVADHSSAKQEYTHKAGSSKHHGPIPATPGMLPQKMSLDKYREKRKLETLDVDTRDHYLAAHAEQQHKHGPAQAVTGTSVTSPIKMKLPLTNSDRPEKHVAEKKERSGSLKLRIPIPPPDKGPSKEELKMKIKVASSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPANRHHSSHKYLHMHSGGSKHTADGMPPTVLRSPVGLGPEGVSSASSARKKLHSSEASHNHHSKMSKSSKSAGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVEPHGPEANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM
What is the function of this protein?
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).  The activity of this complex is regulated by binding with 7SK snRNA (By similarity).  Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:16245309, PubMed:23060074, PubMed:12037670).  In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity).  Involved in early embryo development (PubMed:19364821).
What are the official names of this protein?
Cyclin-T2, CycT2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Note=Nucleus in differentiating cells.
Protein: GRPE_CAMJ8
Sequence: MSEQKQEFENENAENSEHLQDENLQNIEDVEQNRLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAINVECHDEISLKIKEGVQNTLDLFLKKLEKHGVALIKEEKEFDPNLHEAMFHVDSQNHQSGEVVTVLQKGYKIADRVIRPTKVSVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALF_STRR6
Sequence: MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQIQAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAIQASVEERIDVFGSEGKA
What is the function of this protein?
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
What are the official names of this protein?
Fructose-bisphosphate aldolase, FBP aldolase, FBPA, Fructose-1,6-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family.
Protein: PNM8A_MOUSE
Sequence: MSEPVAMTLLEDWCRGMGMDIHRSLLVTGIPEYCSHAEIEETLNGVLLPLGTYRVLNKIFLRQENVKAALVEVSEGVNLSSIPREFPGRGGVWRVVCRDPTQDDDFLKNLNEFLDGEGRTWEDMVRLLKLNPNPPLPNSNQPPPNWAEALGLLLGAVVQVIFYMDAAIRSRDEEARAEEAAEAELMEAWASTARKRVKKEPGLGVEVGSAFKMEDRNYWKNTEDHGDPPKPLVRRPGGKIRSRRRKQKKNLKQEPICWRKSQGSNYNSNYNKVNLEAGEAAQSSEIPESVKSNKKPFVKQEETVWKKKRVWRDPSDLPRSALPAADSPGNLEDSDQDGGPENPAKKKAMTWASNKIPVPTRKKKKMVSLGTLSYVLLDAEATKNKTAILKKGLGARRAVSVPHDAPASTSRPQKTKLGAFPRVSKDSRKL
What are the official names of this protein?
Paraneoplastic antigen-like protein 8A, PNMA-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the PNMA family.
Protein: RS5_SINFN
Sequence: MAQERRGSREDRQNREERDSEFVDKLVAINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAIRKATEAAKRDLIFVPLRGGRTLHHDVNGRHGAGKVLLRSAKAGTGIIAGGPMRAVFETLGVHDVVAKSTGSSNPYNMVRATFDALKNQMHPKDIAAQRGMKYATLQARRVAAGAASEE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SYL_METM7
Sequence: MDQNGVNAGNGHKSIDLIQIMDKWQKKWTEAKIFEAEHDLRDKFFITAAFPYLNGVLHAGHLRTFTIPETIARYQRMKNKNVLWTFGFHVTGTPILGLANQIKERKEDIIWAYNNLHNIPMDELIKLDTPEAIVECFSKKATEAFKRMGFSLDWRRNFKTDDKVFSKFIEWQFYKLKEMGHITKGSHPVRYCPKCENPVEDHDLLHGEESTTVEYSLIKFTSEFDGKEIIMPMATLRPETLFGVTNAWVNPNEMYVMAEVYDEIQKLDSEDVDLKYNGIWIVGKECADKLKEQDRKIEILKEIKGSELLGLKIKNPVTKKEVPLFPADFVEMGIGTGCVMGVPAHAPYDYIALRDLGKIEEVGLIPLIEIEGYDKFPAKEIVEKLGVKDQNDDELLEQATSKIYKDEFHKGKLNENCGEYAGISVKDIKEKLTKDYLNSNIAEIMYEFSEQKVVCRCGEKCIIKTVKGQWFINYSDENWKKLAHECIDSMNFAPENIRQEFHNKVDWMKDKACARKKGLGTLLPFDENWIIESLSDSTIYMAYYTIARFINEGLTPEQLVPELFEYVFLGNGNVEEIAKNSNISKETIEEMRKEFLYYYPLDWRCSAKDLIPNHLTFMIFNHVALFKKEHWPRGIEINGYVTIEGKKLSKSKGPVLPVSEVAENFGADVARFYITTCAELPQDADVKFKEMEKARDNLIKLYELAVSVMEEESTQKEFSLIDKWLLHKTYSSIKGAETAYEEFQLRKIGLMFYELINDLRWYKRRGGENNNVLKEVVEIWTKLLSPVTPHLCEEIWEKLGYSGFISQEMYPEIKSELINEDLELGEEFIKSAMEDIRNIKGVAKINPEKMYLYTADDWKYDLLEFMNENSEKNVKAIIPLVMKEDKFKRHGKEVMKLINEIMKIGVKKAIAEVEILENAKTFIESEFDCEVIVNGEDVKGKKKFAIPYKPAIYME
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_CLOAB
Sequence: MNIENLIKGINGLDNKVMSKIQKRLDNLTKPLGSLGTLEDIVKQLGGITGEVYPSVKNKTVIIMCADNGIVEENVSSCPKSVTASVTRNFMKGFTGINVFTRHAGADIEVIDIGVDADINEEGIINKKIRRGTSNMIKGAAMTRDEALKGLEVGIEAVKELKDKGVNLIGTGEMGVGNTTTSSAVASVLTGCPVDEMVGIGSGLTKEAFRNKIQIVKEAIALNKPNKEDPIDVLSKVGGFDIAGLAGCFLGAAIYRIPIVIDGFISASAALLAVKINPLVKNFIIPSHGSAEPGSKWIMKELDLEPMLNLKMRLGEGTGAALAFQIVDMAVFSYLEMGTFENAEIEPYKPLK
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: CLPP_ALBFT
Sequence: MGAMQTQALGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDYVANLVVAQLLFLESDNPDKDISFYINSPGGSVSAGMAIFDTMNFVKPDVSTLCTGMAASMGAFLLAAGAKGKRFSLPNSKVMIHQPSGGSQGQATEIEIQAREILKTREQLNKILAERTGQPLARIERDTERDYYMSADECKEYGLIDQVISKRA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACOX1_MOUSE
Sequence: MNPDLRKERAAATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREFGIADPEEIMWFKKLHMVNFVEPVGLNYSMFIPTLLNQGTTAQQEKWMHPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITRGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGSAAQSLSKACTIAIRYSAVRRQSEIKRSEPEPQILDFQTQQYKLFPLLATAYAFHFLGRYIKETYMRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVQSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTLVDINSLDSLTEAYKLRAARLVEIAAKNLQAQVSHRKSKEVAWNLTSVDLVRASEAHCHYVTVKVFADKLPKIQDRAVQAVLRNLCLLYSLYGISQKGGDFLEGNIITGAQMSQVNSRILELLTVTRPNAVALVDAFDFKDVTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYYKHLKPLQSKL
What is the function of this protein?
Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs.
What are the official names of this protein?
Peroxisomal acyl-coenzyme A oxidase 1, AOX, Palmitoyl-CoA oxidase, Peroxisomal fatty acyl-CoA oxidase, Straight-chain acyl-CoA oxidase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: LEUD_YERPN
Sequence: MAKFIQHIGLVAPLDAANVDTDAIIPKQFLQKVTRTGFGQHLFNDWRFLDDAGKVPNPDFVLNLPRYQGATILLARENFGCGSSREHAPWALTDFGFKVVIAPSFADIFYGNAFNNQLLPVTLSEADIDTLFQLVKENEGIEFVVDLEQQTVNAGGKSYAFEIDPFRRHCMINGLDSIGLTLQHEHNISAYEKQQPEFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ATPE_VEREI
Sequence: MNTIHVDVVSAEESIFTGQARFVALPGEVGELGIYPRHAPLITRIKPGSVRIEMADGSEEFVFVAGGLLEVQPHCVTVLSDTAIRGKDLDDEKANAAKAAAEEALKNAKSDLDLAKAQSELAVMAAQIAALRKFRQKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TRUB_MYCTU
Sequence: MSATGPGIVVIDKPAGMTSHDVVGRCRRIFATRRVGHAGTLDPMATGVLVIGIERATKILGLLTAAPKSYAATIRLGQTTSTEDAEGQVLQSVPAKHLTIEAIDAAMERLRGEIRQVPSSVSAIKVGGRRAYRLARQGRSVQLEARPIRIDRFELLAARRRDQLIDIDVEIDCSSGTYIRALARDLGDALGVGGHVTALRRTRVGRFELDQARSLDDLAERPALSLSLDEACLLMFARRDLTAAEASAAANGRSLPAVGIDGVYAACDADGRVIALLRDEGSRTRSVAVLRPATMHPG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, MTB-TRUB, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RSMA_PSE14
Sequence: MTEQYQHRARKRFGQNFLHDAGVIDKILRAIRAKPEDRLLEIGPGQGALTEGLLNSGAQLDVVELDKDLIPILTGQFGNKPNFNLHQGDALKFDFNSLGAEPRSLRVVGNLPYNISTPLIFHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLVPYETLPHPAKDHRVLERVVREAFNQRRKTLRNTLKLLLSSDEITASGVDGSLRPEQLDLAAFVRLADTLSEKVVTE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAM_ECO55
Sequence: MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARNLLFATVEIESEERWNAVASTDVCQRWWKYMTDVMPANPDNSPVSSELQEVFYLP
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_PSYCK
Sequence: MSLSTPLITDSTIQAATWLKNGQLLAYPTESVWGIGCDPFNKQAVMRLLDIKQRPIEKGMIVVTDSPSRITALLEGLTAVERQTVLDSWQADSINATAKQAHTWLLPIPKNLPITIPSWITGAHDSVAVRVIDHPLVKQLCAQMVSVSNPYGFVVSTSCNPSGKPPALSLIEAQSYFLGDNVNSDECVGYLKGETLGYQLPSQIGDALTGQVIR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KU_PSEAE
Sequence: MARAIWKGAISFGLVHIPVSLSAATSSQGIDFDWLDQRSMEPVGYKRVNKVTGKEIERENIVKGVEYEKGRYVVLSEEEIRAAHPKSTQTIEIFAFVDSQEIPLQHFDTPYYLVPDRRGGKVYALLRETLERTGKVALANVVLHTRQHLALLRPLQDALVLITLRWPSQVRSLDGLELDESVTEAKLDKRELEMAKRLVEDMASHWEPDEYKDSFSDKIMKLVEEKAAKGQLHAVEEEEEVAGKGADIIDLTDLLKRSLRSRAGGGKDKGSEKAGADAKGRAKSGASRSRRKA
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Stimulates rNTP addition to DSB and end joining (ligation) of linear DNA by LigD, on 3'-overhangs and probably also 5'-overhangs and blunt dsDNA breaks.  Binds both ends of linear dsDNA protecting it from exonuclease activity.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.