PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_BORBR
Sequence: MSAVPDIPGGPAQRLAQACDALRLPADAGQQQKLLRYIEQMQRWNRTYNLTAIRDPGQMLVQHLFDSLSVVAPLERGLPGVVLAIMRAHWDVTCVDAVEKKTAFVRQMAGALGLPNLQAAHTRIEQLEPAQCDVVISRAFASLQDFAKLAGRHVREGGTLVAMKGKVPDDEIQALQQHGHWTVERIEPLVVPALDAQRCLIWMRRSQGNI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFG2_MOUSE
Sequence: MTQGKLSVANKAPGTEGQQHQANGEKKDAPAVPSAPPSYEEATSGEGLKAGTFPQGPTAVPLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVLFVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE
What is the function of this protein?
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis.  Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation.  Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
What are the official names of this protein?
Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35.
What is the protein family that this protein belongs to?
Belongs to the BI1 family. LFG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft. Postsynaptic cell membrane.
Protein: SUB4_TRIEQ
Sequence: CLKTLSVFLAAFAAADARAVFKTQGHKNSEMIPDNYIVVMKDGVSQDDFKAHVSSVASIHSTNKAKRGTNTEGMKREFDIMNWRGYHGHFDRDTLEEILNDSKVDYVEQDQVVRISGLVTQRGAPSWGLGRVSHRQAGSRDYVFDDSAGRGVTIYGVDTGIDINHQDFRGRARWGTNTADRDNADRHGHGTHTASTFAGTAYGIAKNANIVAVKVLSSDGSGSTSGIIAGINYCVQDAQQRGILGKAAMNLSLGGGFSQANNDAVTRAQNAGIFVAVAAGNDNRDARNYSPASAPAVCTVASSTINDSKSSFSNWGPVVDIYAPGSDIIAARPGGGSTTMSGTSMASPHVAGMGAYMIGLGADPRSLCDRLKQLATPAIRNPGSSTTNRLLYNG
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CULP1_MYCTO
Sequence: MTPRSLVRIVGVVVATTLALVSAPAGGRAAHADPCSDIAVVFARGTHQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQRTVASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGGSLPTIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG
What is the function of this protein?
Shows esterase activity, with a preference for short- and medium-chain fatty acids.
What are the official names of this protein?
Carboxylesterase Culp1, Cutinase-like protein 1, Culp1.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCTB_PSEAE
Sequence: MPRILAATAGSFVLKAYFHRWRSLVILALLLAPLLWPLQYFAERYYSEQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPGDPLLQKIANEALADIRRRTGADVIYLLQPDGTTQVASNWAQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIKRGYYFASAVKEGSRIIGVLVVKVDLEHIERLWGNSPEQLLVIDNYGVVILSSREDWRFHASRPLSAAERDEIHANIPYPVQDPKPLRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMVASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVTLTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHLLPGVPGVAAMPQEETRA
What is the function of this protein?
Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA (PubMed:21725012).  DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity).
What are the official names of this protein?
C4-dicarboxylate transport sensor protein DctB.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GABT_MOUSE
Sequence: MAFLLITRRLACSSQKNLHLFIPGSRYISQAAAKVDIEFDYDGPLMKTEVPGPRSKELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLQESLMSVAPRGMSQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFTTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVARVGKTLLTGLLDLQAQYPQFISRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLSIFSGILADFK
What is the function of this protein?
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively.  Can also convert delta-aminovalerate and beta-alanine.
What are the official names of this protein?
4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, GABA-T, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: TRPF_RHIEC
Sequence: MKPDIKICGLKTPEAIDRALKRGATHIGFIFFEKSPRYIEPDLAAKLAEPARGKAKIVAVVVDPTNDELDEIVSLLKPDILQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEAYIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSIDYMLSGGLNKNNVADALVKTRARGIDVSSGVETEPGVKSVAMIDEFFDAVETADAPVMAPGS
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: SAMC_DROME
Sequence: MHLLQEPVNKLKFFHALVAGGVAGMVVDIALFPIDTVKTRLQSELGFWRAGGFRGIYKGLAPAAAGSAPTAALFFCTYECGKQFLSSVTQTKDSPYVHMAAASAAEVLACLIRVPVEIAKQRSQTLQGNKQSGLQILLRAYRTEGLKRGLYRGFGSTIMREIPFSLIQFPLWEYFKLQWTPLTGFDSTPFSVALCGAVAGGISAGLTTPLDVVKTRIMLAERESLNRRRSARRILHGIYLERGFSGLFAGFVPRVLWITLGGAFFFGFYDLTTRILGATSTDH
What is the function of this protein?
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.  May mediate the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).
What are the official names of this protein?
S-adenosylmethionine mitochondrial carrier protein homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SELD_SULNB
Sequence: MSSVKLTEYSHGAGCGCKISPMLLDEILESTQKTSVYPQLLVGNANKDDAAAYDLGNGTSVLSTTDFFMPIVDDAFTFGQIAATNALSDIYAMGGKPLMAISIFGWPIDKLSADVAREVIDGGRSICEDAGIPLAGGHSIDSPEPIFGLAATGLVDNANLMQNDSAKKGCYIFLTKPLGIGILSTAQKQKKIEEGHIDPAIQAMTTLNKVGADLAPLESVVAMTDVTGFGLLGHLSEICEASDISAQVWFEKVPLLPNVEKYRQLGCIPGGARKNFASYGDKISEMTQQQREILCDAQTSGGLLVIVKKDGLEAFKKVTEAAGLTLEPIGETTVKSQHLVEVL
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: Y32K_BNYVG
Sequence: MADGEICRCQVTDPPLIRHEDYDCTARMVQKRIEIGPLGVLLNLNMLFHMSRVRHTDVYPCLNNIMSVSVSLDVPVSSGVGVGRARVLIFTTSRERVGIFHGWQVVPGCFLNAPCYSGVDVLSDELCEANIINTSVSSVAMFNRSYKPEDVWILLLTSSTCYGYHDVVVDIEQCTLPSNIDGCVHCSGVCYFNDNHCFCGRRDSNPSNPPCFQFIKDCNELYGTNETKQFICDLVGDANLDSVNTLTKEGWRRFCDVLWNTTYGDVESRTFARFLWFVFYHD
What are the official names of this protein?
RNA-4 uncharacterized 31.9 kDa protein.
Protein: RS5_XANCP
Sequence: MAEERAPRGRDRDRNREEKVDDGMIEKLVAVNRVSKTVKGGRQFTFTALTVVGDGLGKVGFGYGKAREVPVAIQKSMEQARKNLATVDLNNGTLWHAVKSGHGAARVYMQPASEGTGVIAGGAMRAVLEAVGVKNVLAKAVGSRNPINLVRATLKGLSEVQSPARVAAKRGKKVEELNHG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: NRDI_MYCSS
Sequence: MGNIVYFSSVSENTHRFVEKLELPATRIPILGRIQDPDFVREPYVLVLPTYGGGHANGPDPDAGGYVPKQVIAFLNNEHNRSLIRGVIAAGNTNFGAEFGYAGDVVSRKCGVPYLYRFELMGTTDDVLAVRAGLENFWKEQTCHPPSQLQSL
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: PHCB_CYAPA
Sequence: MLDAFGKVVAQADARGEFISSAQFDALSKLASEGNKRLDAVQGITASAATIVSSAARSLFAEQPQLIAPGGNAYTNRRVAACLRDLEIVLRYITYATLAGDSSVLDDRCLNGLRETYQALGVPGSSVAVAIQKMKDAAVSVVNDPSGVTVGDCSALASEVASYFDRAAAAVV
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
C-phycocyanin beta chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Peripheral membrane protein; Stromal side. Note=Part of the phycobilisome rod.
Protein: ACCD_GLUOX
Sequence: MSWMTDYVRPKLRGLLQRDVPDNLWTNCESCGQMMLTKELERSEKVCPHCGHHMRATAKERLGWTFDGGEYTTIELPKMPVDPLGFKDSKRYTDRLKDARHKSHLDEALVVAHGMIKGQKAVVAVMAPEFLLGTMGAALGEAFVAACRLAVLQKAPLVVYTASGGARMQEGVVSLMQMPRTTIGVQMLQEAGLPYVVVFTNPTTGGVSASFAMLGDVHIAEPNALIAFAGPRVIQDTVREKLPEGFQRSEYLREHGMVDIVAKRSELPELLGRILGIMMRQKTVSDAAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y200_CAMHC
Sequence: MFEGFDLSKMNEMLGDLQKKAQQMENENANREFSVKSGAGMVEIKISGKGEVLDVSIDDSLMSDKDSLQILLISAINDAVKLIDNEKKNLAAKMLGDIGNLGGFGCEK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CHAB381_0200.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PHAR1_HUMAN
Sequence: MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
What is the function of this protein?
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755).  Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
What are the official names of this protein?
Phosphatase and actin regulator 1.
What is the protein family that this protein belongs to?
Belongs to the phosphatase and actin regulator family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).
Protein: PPSD_MYCTU
Sequence: MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGCRFPGNVTGPESFWQLLADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFVSDVDAFDADFFGITPREAVAMDPQHRMLLEVAWEALEHAGIPPDSLSGTRTGVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPAVAVDTACSSSLVAIHLACQSLRLRETDVALAGGVQLTLSPFTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGVVVLKRLADAVRDQDRVLAVVRGSATNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVETHGTGTVLGDPIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLAVQRGHIPRNLHFTRWNPAIDASATRLFVPTESAPWPAAAGPRRAAVSSFGLSGTNAHVVVEQAPDTAVAAAGGMPYVSALNVSGKTAARVASAAAVLADWMSGPGAAAPLADVAHTLNRHRARHAKFATVIARDRAEAIAGLRALAAGQPRVGVVDCDQHAGGPGRVFVYSGQGSQWASMGQQLLANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDRIQPVLVGMQLALTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRLMARLSGQGAMALLELDADAAEALIAGYPQVTLAVHASPRQTVIAGPPEQVDTVIAAVATQNRLARRVEVDVASHHPIIDPILPELRSALADLTPQPPSIPIISTTYESAQPVADADYWSANLRNPVRFHQAVTAAGVDHNTFIEISPHPVLTHALTDTLDPDGSHTVMSTMNRELDQTLYFHAQLAAVGVAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSELAATHPLLGAHIEMPRNGDHVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIALAAASEALGTAADAVAPNIVINQFEVEQMLPLDGHTPLTTQLIRGGDSQIRVEIYSRTRGGEFCRHATAKVEQSPRECAHAHPEAQGPATGTTVSPADFYALLRQTGQHHGPAFAALSRIVRLADGSAETEISIPDEAPRHPGYRLHPVVLDAALQSVGAAIPDGEIAGSAEASYLPVSFETIRVYRDIGRHVRCRAHLTNLDGGTGKMGRIVLINDAGHIAAEVDGIYLRRVERRAVPLPLEQKIFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQAKSMADDFVQQWRSPMRRVHTADIHDESAVLAAFAETAGDPEHPPVGVVVFVGGASSRLDDELAAARDTVWSITTVVRAVVGTWHGRSPRLWLVTGGGLSVADDEPGTPAAASLKGLVRVLAFEHPDMRTTLVDLDITQDPLTALSAELRNAGSGSRHDDVIAWRGERRFVERLSRATIDVSKGHPVVRQGASYVVTGGLGGLGLVVARWLVDRGAGRVVLGGRSDPTDEQCNVLAELQTRAEIVVVRGDVASPGVAEKLIETARQSGGQLRGVVHAAAVIEDSLVFSMSRDNLERVWAPKATGALRMHEATADCELDWWLGFSSAASLLGSPGQAAYACASAWLDALVGWRRASGLPAAVINWGPWSEVGVAQALVGSVLDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQVVEELDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQSTVEPAVPLDKPLTELGLDSLMAVRIRNGARADFGVEPPVALILQGASLHDLTADLMRQLGLNDPDPALNNADTIRDRARQRAAARHGAAMRRRPKPEVQGG
What is the function of this protein?
Part of the PpsABCDE complex involved in the biosynthesis of the lipid core common to phthiocerols and phenolphthiocerols by successive additions of malonyl-CoA or methylmalonyl-CoA extender units (PubMed:15749014, PubMed:20553505).  PpsA can accept as substrate the activated forms of either icosanoyl (C20), docosanoyl (C22) or lignoceroyl (C24) groups from FadD26, or a (4-hydroxyphenyl)-C17 or (4-hydroxyphenyl)-C19 fatty acyl from FadD29 (PubMed:15749014, PubMed:20553505).  PpsA initiates the biosynthesis and extends its substrate using a malonyl-CoA extender unit.  The PpsB and PpsC proteins add the second and third malonyl-CoA extender units.  PpsD adds an (R)-methylmalonyl unit and PpsE adds a second (R)-methylmalonyl unit.  The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product (PubMed:15749014).
What are the official names of this protein?
Phenolphthiocerol/phthiocerol polyketide synthase subunit D, (Phenol)carboxyphthiodiolenone synthase subunit D, Beta-ketoacyl-acyl-carrier-protein synthase I, Phthiocerol synthesis polyketide synthase type I PpsD.
Protein: MBD2_HUMAN
Sequence: MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
What is the function of this protein?
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669).  Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175).  Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666).  Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179).  Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179).  May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568).
What are the official names of this protein?
Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2.
Protein: PROA_LISMC
Sequence: MTELIKKGSGAKEASQFLAQATTKHKNAALLNLSNDLLIHTATLLQENEKDILRAKQKGTPETMIDRLRLTEERIKEISEAVKQVVALKDPIGEVTNMWKNEAELTIGKTRVPLGVIGIIYESRPNVTVDASVLCFKTGNAVILRGGSDAIDSNKALMSVIQDSLEASGFPRSSVQLIEDTSRETAQDMMRLNRFLDVLIPRGGARLIQTVLENATVPVIETGTGNCHIYVDKAAEKQMAIDILVNAKCSRPSVCNAAETLLIHRDVAEDYLPAMETALKEYDVELRADERAKGILQEAKAATESDWEDEFLDFILAIKVVDSAEEAIDHINKYGTKHSEAIISNDYATGQAFHQKVDAAAVYINASTRFTDGFAMGFGAEIGISTQKLHARGPMGLTELTSTKYIIFGDGQIRN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_COLMA
Sequence: MAAKDVLFGNDARVKMLRGVNILADAVKVTLGPKGRNVVIDKSFGGPIITKDGVTVAKEIELEDKFENMGAQMVKEVASKANDEAGDGTTTATVLAQAIVNEGLKSIAAGMNPMDLKRGIDKAVIAAVEALKESSTPVTDNKAIEQVGTISANSDETVGKIIATAMEKVGTEGVITVEEGQALTDELDVVEGMQFDRGYLSPYFINKQENGTVELENPFILLVDKKISNIRELLTTLEGVAKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVATLTAGTVISEEIGMELEKVTLEDLGQAKRVVISKDTTIIIDGIGVEADIQARVSQIRGQIEDSSSDYDKEKLQERLAKLAGGVAVIKIGAATEMEMKEKKSRVEDALHATRAAVEEGVVAGGGVALIRAADAIKDLEGANEDQTHGINVAIRAMEAPLRQIVANCGDEPSVVLNEVRNGKGNYGYNAGNSTYGDMIEMGILDPTKVTRSALQFAASVAGLMLTTEAMITDAPVKDAGGMPDMSGMGGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_CHLTA
Sequence: MATPCIQNAFRRKTLPVRIGDLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLREVHACEHIKDRLIQQNISIPLVADIHFFPQAAIHVVDCVDKVRINPGNYVDKRNMFTGKIYSDEQYAHSLEHLMNKFSPLVEKCKRLGKAMRIGVNHGSLSERVTQRYGNTIEGMVYSALEYAEVCVAMDYHDVIFSMKSSNPKVMVAAYRSLAYELDQREWSYPLHLGVTEAGSGTAGIVKSAVGIGTLLSEGLGDTIRCSLTGSPINEIPICIDLLKQTTELSERWGEADNPFAIHSSKQLGTRNTLNTPPWGNVYGLLINLTDVQLLTAEPIELLQCLGIDTTTGKIDPTTPEGVVVPKAMRSSPIVSEIEKHLLVFNKEDAPILNPMNEEEWLSEETLSAPFVYFEVTDIHTARRFFSLRQHSTQPVCLSFSLDPHLSKNEAIIDLSARLGALLLDGLGSCVLLDFVDIKLSRTLGFLILQSANIRSVTVEYVSCPGCGRTLFDLLAVSQRIRERTQHLPGGLKIAVMGCIVNGPGEMADADFGYVGSKPGMIDLYVKHKCVKSCIPIENAEEELVQLLKEHGVWKEPE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HIS5_BUCDN
Sequence: MGKIIILNTDCANFTSIKSAIEKLGYCCMITAEPSIVKNAKKIILPGVGTALAAMNFLSQKKLVDIIKTFTNPILGICLGMQIFCNFSEESNGVKTIGVVKTSVLHLKTNNLPLPHIGWNQISFNKCHALFKDIPNNSRFYFVHSYIVPVNKYTLSVTNYGMNFSSVIQKNNFWR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PSEF5
Sequence: MAGKTLYDKLWDSHLVKQRDDGSALIYIDRHIIHEVTSPQAFEGLRLAGRKPWRIDANIATPDHNVPTTPERKGGIEAIADQVSRLQVQTLDDNCDEYGIVEFKMNDVRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMKNMLVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHAIEFAGSAIRELSVEGRMTICNMSIEAGARVGLVAADEKTVAYVKGRPFAPKDAEWDLAVEAWKDLVSDADAKFDTVVELDAAQIKPQVSWGTSPEMVLAVDQNVPDPAKEMDLVKRDSIVRALKYMGLSANQAITDIQLDRVFIGSCTNSRIEDLRAAAVIAKGRKVASTIKQAIVVPGSGLVKAQAESEGLDKIFLEAGFEWREPGCSMCLAMNPDRLESGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVSGRFVDVRELI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GLGC_MYCTO
Sequence: MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVGKGVWI
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: NIRG_PARPN
Sequence: MRRQTLPPEALDDTDRAILNRLQEGFPLTPRPFDDAGAALGLTGAQLIERLERLRAIGAITRFGPFYDAAAMGGAFCLCALSAPQADFDRIAALVNAHPEVAHNYARDHALNMWFVLATATPEGIAETAGRIEAETGLTVWRFPKLREFFIGFRVAA
What is the function of this protein?
Involved in heme d1 biosynthesis.  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (PubMed:21969545).  Siroheme is probably decarboxylated to monodecarboxysiroheme, which is in turn decarboxylated to didecarboxysiroheme (PubMed:21969545).
What are the official names of this protein?
Siroheme decarboxylase NirG subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.