PharMolix/UniProtQA huggingface dataset:
Protein: FEMX_WEIVI
Sequence: MPVLNLNDPQAVERYEEFMRQSPYGQVTQDLGWAKVKNNWEPVDVYLEDDQGAIIAAMSMLLGDTPTDKKFAYASKGPVMDVTDVDLLDRLVDEAVKALDGRAYVLRFDPEVAYSDEFNTTLQDHGYVTRNRNVADAGMHATIQPRLNMVLDLTKFPDAKTTLDLYPSKTKSKIKRPFRDGVEVHSGNSATELDEFFKTYTTMAERHGITHRPIEYFQRMQAAFDADTMRIFVAEREGKLLSTGIALKYGRKIWYMYAGSMDGNTYYAPYAVQSEMIQWALDTNTDLYDLGGIESESTDDSLYVFKHVFVKDAPREYIGEIDKVLDPEVYAELVKD
What is the function of this protein?
Involved in the synthesis of the bacterial cell wall.  Catalyzes the addition of alanine into the interchain peptide bridge of peptidoglycan precursor using aminoacyl-tRNA(Ala) as amino acid donor.  This alanine is added to the epsilon-amino group of the L-lysine of the peptidoglycan UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine, in a ribosome-independent mechanism (PubMed:11083873, PubMed:4248527, PubMed:12679335, PubMed:15901708, PubMed:23744707).  Specific for UDP-N-acetyl-muramoyl-pentapeptide.  Has no activity toward UDP-N-acetyl-muramoyl-tetrapeptide or UDP-N-acetyl-muramoyl-tripeptide (PubMed:15901708).  Also acts on L-seryl-tRNA(Ser) (PubMed:4248527).
What are the official names of this protein?
UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
Protein: RL21_EHRCR
Sequence: MFAIVETGGKQYKVKEQDVIKIEKLNASVGEEVTLDKVIALADVNNNIVFTHNAIVTASVLEQCRNDKIIVFKKKRRKNYRRKNGHRQYMTVLRVTKINNME
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: PTN11_HUMAN
Sequence: MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
What is the function of this protein?
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573).  Positively regulates MAPK signal transduction pathway (PubMed:28074573).  Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573).  Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669).  Dephosphorylates CDC73 (PubMed:26742426).  Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).  Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884).
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FPPS_MYCTO
Sequence: MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
What is the function of this protein?
Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP).  May be used for squalene and possibly sterol biosynthesis.
What are the official names of this protein?
(2E,6E)-farnesyl diphosphate synthase, E,E-FPP synthase, FPP synthase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_BRASB
Sequence: MASLKDMRVRIASTKATQKITKAMQMVAASKLRRAQLAAEAARPYAEKMDAVISNIAAASAGSPASSKLLAGTGRDQVHLLLVCTGERGLSGAFNSSIVRLARERALALMNQGKDVKFFCVGRKGYEQLRRQFEKQIIAHVDLRSVRQIGFVHAEDIAKQVIARFDAGEFDVCTLFYSRFKSVIAQIPTAQQIIPLVVEAPAANAAPVALYEYEPEEDEILSALLPRNVGVQIFRALLENNASFYGAQMSAMDNATRNAGEMIRKQTLVYNRTRQAQITKELIEIISGAEAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YPDB_ECO57
Sequence: MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTSSTPAATVTRENDTINLVKDERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDLDFEVPVSRSKVKEFRQLMHL
What is the function of this protein?
Member of the two-component regulatory system YpdA/YpdB.  YpdB regulates expression of yhjX by binding to its promoter region.
What are the official names of this protein?
Transcriptional regulatory protein YpdB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL3B1_BOVIN
Sequence: MDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAEVSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHKFDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNAGQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFDTFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL
What is the function of this protein?
Oxidizes medium and long chain saturated and unsaturated aldehydes.  Metabolizes also benzaldehyde.  Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde.  May not metabolize short chain aldehydes.  Can use both NADP(+) and NAD(+) as electron acceptor.  May have a protective role against the cytotoxicity induced by lipid peroxidation.
What are the official names of this protein?
Aldehyde dehydrogenase family 3 member B1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
Protein: CLAP3_CAEEL
Sequence: MTSRMQPKSGVYSVSKADFTKIFEDVPKVPITSAVDLRNKFDAVRIILSNSSEDWNKRQTQLKTVRSLVIHGEKVVDRPTMIAHLVQLLGCFELAVKDLRSQVLREAAITCSFIVSKYGIETHSIGEDILVPAMSQVAVSTKIMATSASTLTEFIVEYVQTRQVFTILSSFSTSKDKSQRRQLAALLEIVISKWSDRIKKQIMRQICELIKSAINDADSETRAAGRRAFAKLDEMHSEEADALYLELDHSKQKMLRGGDAASSWASVNSEKGSIPIRSKLSAGSKAHMNISAKFLAQRSASAIDPKATKFAGPSRLVRPTSTKTMARQDTSPAGCKYSNFISMFFKTLLLSAKIPYPNRPGSRTRTSSITSTDSRDTSPTRRNSPLPPETQKARVKYGNGSFFAKLGMPDTTDDDEFLLPIRIRSPLKTPTIEAHDKVSQVLKECCSSSVSEKKEGIKKLLPIVADTSLNPIEIKNIGNCLNRLLSDASNTMVLEIYSIFVRTHSSRLSEWLRLALAKLFARKAAETLPNTKKQIGHTLNVILECFNAHHQLVTVCELMCDPIHLMVPKARVVLLEYLTSLLDEYTEPGASINAKELKTAIRKMLTWASDPRLSILLTPHVEKAICSMFCVNVADFSALISDLDSEQKNWIHQTLQRNGLENGISSNNIATNSGATASRETSNTSFQKESTSFGLPEFGARKGGTGVNLGSLNISNNLALSRLEEQSTSRLMEKVNLNSTVTLPPDTLEKIQNVQDLLQKMRSSENADEQESAISSIYMMICDGGFGVWEQCYAKLLLNLFEILSKSRSENNKKMCLRILGKMCTAQAAKLFDSTEMAVCKVLDAAVNTNDATTALAVEDCLRTLATHLPLSNIINIAKVILNQEPIDDERASLVLKMVTRLFEELPAEELNNIVDDITPTIIKAYQSTSSTVRKTVVYCLVAMVNRVGEQRMTPHFTKLPKAMTNLIQVYVNRAISTSLPRL
What is the function of this protein?
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.
What are the official names of this protein?
Protein CLASP-3.
What is the protein family that this protein belongs to?
Belongs to the CLASP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FETP_HAEIE
Sequence: MARTVFCEYLKKEAEGLDFQLYPGELGKRIFDSVSKQAWSEWIKKQTMLVNEKKLNMMNAEHRKLLEQEMVNFLFEGKDVHIEGYVPPSN
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: MIAB_PSELT
Sequence: MRVFFKTYGCQMNLNDTETMAGILSQHGYEVVNLPEEADIVILNTCVVRQKSQEKYHSALGQFVKLKKSGKIKLIGIAGCGSNLEGEELIKSGADFVIGSRSIGKIAEVLQKAARGEKIVYLEDDICTVDSKTPRMRFSKHHAWITIIHGCNRFCTYCIVPYTRGREKSRPLPDVLLEVEKLAKNGVKEITFLGQNVDAYGKDLKDGTNLASLIEQAGKFEQIKRIWFLTSYPTDITDKLIETVAEDPKAAKSFHIPVQSGSNRILRLMNRRYDRDQFLQLVEKIRSKIPHASISSDIIVGFPTETEYDYMQTMDLVRKARFERLNLAVYSPRQGTVASKYFKDDVPREEKVQRLNKLLELQKQINRELNMQYLGKVVEIIVEGKTKEGLYYGRDIRNKVIIFSSQEVSEGENVLLKIDKITAGPLYGKLQKKCGL
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_NEIMB
Sequence: MKRIFLFLATNIAVLVVINIVLAVLGINSRGGTGSLLAYSAVVGFTGSIISLLMSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGASRNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIANLIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMISALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSL
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNY_RHOBA
Sequence: MNPQLASTILYCLFFFFLGIAAVLAFIQRQAVKRRERLDAEAEAVLESARREAETRGNQIIVDAREKALAIKAEADREVAAMRETEQIRDRKLDAREDQLASGQESLRKAQRGLESSQTRLAAQMRNLTEQRAELDRLVQESQRALEKVSGMTQEEAAEKLMQSLRQDLEHEIGSTVLKHQRELGRRVDAQAREMLLTAMQRYASVHTADTTTSTVGVPTDDMKGRIIGREGRNIRAFEKATGVDLIIDDTPGVVVVSGFDPVRREVARMSLEKLIADGRIHPSKIEETVEQAGKEIQAFILQKGQEAAGEVNVSGLHDRVIEMLGRLHFRTSYSQNVLRHSVEVAFLAGMMAEMIGLDGDLARRCGLLHDIGKAADHELEGGHPKIGADLLRRSKENDEVVHAAKGHHDEIVTEFPYTMLVATADACSASRPGARRESLERYVKRMEELESIAQRFDGVQQAYAISAGRELRVMVGSQQVSDERAAAICRDIASTFEKELTYPGEIKVTVVREARFTNTAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL28_ECO7I
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLAELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: G6PC2_HUMAN
Sequence: MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWVAVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAKKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTSLTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
What is the function of this protein?
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum.  May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
What are the official names of this protein?
Glucose-6-phosphatase 2, G-6-Pase 2, G6Pase 2, Islet-specific glucose-6-phosphatase catalytic subunit-related protein.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: IF1_BACVZ
Sequence: MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHFIRILPGDKVTVELSPYDLTRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2246_YERE8
Sequence: MSEQCPCGSTLEYQRCCEPYIMGTEIAAKPSILMRSRYSAYVKKNVDYLIATWHPDCNAEQWRDGIIQSFSNTTWQGLTVIAEMAGDHDNEAFVEFIARFKDANSTQVSAMHERSRFLRIKEHWYYIDGIRPSVGRNDTCPCGSGKKYKKCCGR
What are the official names of this protein?
UPF0225 protein YE2246.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: NADD_CHLPD
Sequence: MHVAVFGGTFDPPHNGHLAMCLLARELLHIDKVILSISNNPFKLLRSDHDDHRKNMVGLLASELKKTELPAEVSGWELQKKTPSYTVELLRFLRTEYPDVQLTLLVGEDSYREFPLWKSYEELVLLCRIAVFRRVPPEQIAHREQRLEMIGNVRFIDFDCPISSTTIRADIASGRPVTAKIPSAINRYIIDHRLYRD
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: F12AI_BOVIN
Sequence: MASRLTPLTLLLLLLLAGDRVTSDMIVGPGNLQEGESEGDSQKGGILDGESIQGNEDSPTLPITNLTVVPATVTKPFSQPATEPVQSTIQPTAEPFCLAPVTSCSDSEIRSAEAVLGEALTDFSLRLYQDFSVLKKRETNFIFSPFSIASLLTQILLGAGGETRVSLEHLLSYPQNFSCVHHALRAFMSEGFTSFSQIFHSSDLTIKDTFAEASQRLYGSSPRPLGNDSTASLELINDWVAKKTNLRIRRLLDSLPEDTRLILLNAVALSAKWKIAFDKGRTSTKPFHLKSSAIKVPMMNSKKYPVASFTDRTLNRPGGRLQLSHNLSFVILVPQTVKHHLQDLEQALSTAVFKAVIKKLEMTKFHPTHLTMPRIKVQSSQDMLDYFDFIYDVNLCGLTEDPDVQVSGIRHQATLELTESGVDATAASVVSVARNLLLFEVQQPFLFLLWDQQHKFPVFMGRVYDPKG
What is the function of this protein?
May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.
What are the official names of this protein?
Factor XIIa inhibitor, XIIaINH.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y4069_SHEHH
Sequence: MTADNPNQGQIAEHAARQYLQQRGLIFVEQNVRYRFGEIDIVMKDGSDWVFVEVKYRSASQYGGAVNSLSAAQAGRIRKAASHYIQLNRIDAICRFDVIAADPQGIQWIRDAF
What are the official names of this protein?
UPF0102 protein Shal_4069.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: TFE_THEPD
Sequence: MNAHEALAEIAGKMFGDNAKKVMMVLASNVEVSDEDLAKDLKMDPPELRKLLNDLFEARLVKYRRARDENIGWYKYYWRITDEPIQQILSDRKRLTLSILEKVLSLEENSETYVCPKCGTRYTVDEAENNNYTCEVCGEVLEPFDNTHRVEKLKRAIELLGNWDPSPKQQASRAIPHA
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: RL7_SHESA
Sequence: MSITKDQILEAFAAMSVMEVVELIEAMEEKFGVSAAAAVVAGGAADAGAAAEEQTEFTVMLTAHGDNKVAVIKAIRGATGLGLKEAKAMSEAAPVAVKEGVSKEEAEALKKELVEAGATVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: HIS4_MYCVP
Sequence: MTSVNPSSSKPSALILLPAVDVVEGRAVRLVQGQAGSETEYGSALDAAMTWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVAVELSGGIRDDDSLAAALATGCARVNLGTAALENPQWCAKVVAEHGDKVAVGLDVKIVDGQHRLRGRGWETDGGDLWTVLDRLDGEGCSRFVVTDVTKDGTLNGPNLELLTQVCERTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLPQALDAVGP
What is the function of this protein?
Involved in both the histidine and tryptophan biosynthetic pathways.
What are the official names of this protein?
Phosphoribosyl isomerase A, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, N-(5'-phosphoribosyl)anthranilate isomerase, PRAI, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRL_RAT
Sequence: MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPELFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKVPPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKIISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRCQIVHKNNC
What is the function of this protein?
Prolactin acts primarily on the mammary gland by promoting lactation.
What are the official names of this protein?
Prolactin, PRL.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KHDC3_HUMAN
Sequence: MDAPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRGGERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATQKAETQRSSIEVREAGTQRSVEVREAGTQRSVEVQEVGTQGSPVEVQEAGTQQSLQAANKSGTQRSPEAASKAVTQRFREDARDPVTRL
What is the function of this protein?
As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity).  Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:31609975).  Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity).  Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity).  As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity).  Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity).  Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).  Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity).  Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity).  Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity).  May regulate normal development of learning, memory and anxiety (By similarity).  Capable of binding RNA (By similarity).
What are the official names of this protein?
KH domain-containing protein 3, ES cell-associated transcript 1 protein, KHDC3-like protein.
What is the protein family that this protein belongs to?
Belongs to the KHDC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (PubMed:31609975).
Protein: RNH_BORA1
Sequence: MSTANPPADLVEMWTDGACKGNPGPGGWGVLMRYGSHEKTFFGGDPQTTNNRMEILAVVEGLRALKRACTVVIHTDSQYVMKGMTEWLPNWKRRGWLTADKKPVKNAELWQLLDAQVARHEVRWQWVRGHNGDPGNEMADMLANQGVASVARN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACRR_ASPA1
Sequence: MSPNMSLTASHPQQPQPTPQSKAQLTRQACNRCHASKLKCLRPPGVTTSKSCIRCIKADTECVYDPPQRFGRPRQKSRPQPESVPPRIEAREPEVTDPRRARHGSTIGARWESSERESNGSLAPSSAAESPYTAAESPDNRSSAAVAAAPLVGMDYASSHFPEPLESERTSELLDAFQSESMQLDVDSYWGETDPVMPPAATVPYSDLLTGPIDLDFTVSDQDDRAKIPKHALDPALSGADTGSTADDYVLDLVQLQASVNQNNRELAAMIRKAQSALGMSDGRVGQALPIPDSQFKTHLQRNLKASEQTLDVLHRINSQFAPVSRETRPPSRSYGLDPTLDRLYADCVSQDHAFGVGGDELGVRATTPPGVSAADPQHSILAFLVLTTYLRLLHNFDALISILQDRLRCSASLDPRRPLHLSEDISASDSSSNPLLDVSLGSFSFSSSSARSLQAMLNVQMINTVLTKIKSSTQRMLLGPDYLPPSSCSSSASTSSTASTTSCSTRAPPSSATGGAHHPATAGSIFFHHAHSHSHSSSDHLFSQPEGRGYAPYNHAFHPPPPSRHTHNYPTPETITPPSSVLGGVSGTTPPPFVSGVDHVVRRALTEVQELELSLRNRARAIQQWSEEGF
What is the function of this protein?
Transcription factor that positively regulates the expression of the cluster that mediates the biosynthesis of acurin A, a highly reduced polyketide coupled to a serine via a peptide bond.
What are the official names of this protein?
Acurin A biosynthesis cluster transcription regulator, Acurin A biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: FLK_ARATH
Sequence: MAEAEDQQNFVAHNGDQVPDQGSDELHNGLPYQVHDETLVHQPYEVEDPILEPQQYEVPDPTLEPQQYEVPDQTLEPQQYEVDDQLEYHQYQLQDQANEDVQDHSQDDLQYQPQNQEQFQLQDEAHDQAQYQAQGDVQDHNGDEVQDKVEDEEGIPEHLESLQKSEPEEDATVGGEEKRWPGWPGETVFRMLVPAQKVGSIIGRKGDVIKKIVEETRARIKILDGPPGTTERAVMVSGKEEPESSLPPSMDGLLRVHMRIVDGLDGEASQAPPPSKVSTRLLVPASQAGSLIGKQGGTVKAIQEASACIVRVLGSEDLPVFALQDDRVVEVVGEPTSVHRALELIASHLRKFLVDRSIIPFFENQMQKPTRQMDHMPPPHQSWGPPQGHAPSVGGGGYGHNPPPYMQPPPRHDSYYPPPEMRQPPMEKQPHQGISAYGREPPMNVHVSSAPPMVAQQVTQQMQIPLSYADAVIGTSGSNISYTRRLSGATVTIQETRGVPGEMTVEVSGTGSQVQTAVQLIQNFMAEAGAPAPAQPQTVAPEQQGYNPYATHGSVYAAAPTNPPGGYATDYSSGYGY
What is the function of this protein?
Regulates positively flowering by repressing FLC expression and post-transcriptional modification.
What are the official names of this protein?
Flowering locus K homology domain, Flowering locus KH domain.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.