Protein: SUBA_METRA
Sequence: MRVNTPSLLICGPMISQADAAYLPQVRSSLVHNKDLSYLREAVSELPNLWLRLVREEPSLGEIDVALFLDNLSQWVKGNSTQPTASRDSRNTQWAVLTVLVHIVEYMEYLDNFSSRDEDGCGHLDAHAALLDHLHDGGIQGLCIGLLTALALACAPSHAEIAKYGAVAVRLALCCGAYIDLNEAKSPAKTICVTTRWPGDDGDDKGDIDRKCDEQLQAILDTYPDAYKSVQTDVSTVTITTNEGDVLALLGELEKGGATSKRIDLHGRYHYGGNQAALLKLLQLSKALPMLQFPRGSRLVVPVRNNCSGSIVEDNTALHEMALRCILVENAEWLKTISSSISANTRQAQLLVLGPVNCVPRSLLLRSPQPISLSVSGKADNIYPDQSIAIIGSSCCFPGAENPRQLWEFIRTKQTHGVVDAAGSFDCSFFRKSPREAEYMDPQQRLGLHLAQEALESGGYFSPSSSATKNVGCYLGISSCDYEDNVNSHPPTAYSFTGTARAFASGRISHFFGLTGPSMVIDTACSSSGVAINTACRAIQSGECTMALAGGINLISREARTQENLAAASFLSPTGECRPFDSKANGYRRGEGGGLVLLKKLSSAVADGDVVLGVIAATAVNQSEGNKSITLPSSESQTSLYQRVLESANLKPRHISYVEAHGTGTQKGDPIECQSIRTVFGGTVRPACRQLHVGSIKSNIGHSEAASGIAALLKVLQMLHHRVIPPQANFEELNPAISPLHDDNIEISRHTKPWEERFRAALVNNYGASGTNAAMLVCQPPSIQHRLPLFPNRPCHYPILLTSHSNESLQLYCRNILRFIENQNNVVSDEEVLANTAFHLAQRQDHSLSFRLTFSVSSIEELKLKLQQQSTSQSYKDGPIQKHSAQPVVVVLAGQTGRRVRLSHEIYASSELLQRHLGRCDRALQTMGFASLFPGIFDTEPLEDLVQAHCMLFSLQYSVAMSWIDSGLKIDALVGHSLGQLTALCISGMLSLQDGLKLISGRASLIQSKWGAECGAMLSVDADAETVQNLADSLPAGYKVEIACYNSSQSHVVVGTKAAITAFEKAADLRGVSLRRLAISHGFHSEMIDCILPDYNKLVQGLVLHPPAIAIEPCSQSGHSWANATPEIIARQSREPVYFANAISRLEKRFGSCIWLEAGWGSAGVNMARRALTHGPTRSLSTHSFYPAALGEPDSVKALADTTINLWNAGIRVQFWLYHRSQTGSPAPLELPLHPFMKSEYLLPVVKHSKKAQSEKDGQPIIQEKATLVSLIGKTQNAGVQTVEYSINQNSEEYSVYVRGRTVFEHLLAPVSMYIESATRAFRLLSTHKLVSFSTSASMELKNLKLHAPFGFDLQKSLRMILRKLGEDAWEFRVESHPIHEKERGSVLQATGVITLQEVYSHLAPHRPLLRRLYDRCEELGKDVSASVVQGDFIKKIINSVARYDDRYIGVRSITSKGFETVAHVFEPEIASQFTPTTPFNPLLLDNFLLIAEIQANNLGGVTPDEIYVGNGFDAATAYTNAEDSEPSTKGHWVGLYSFDHQENDGILCDIFIFCAERKILSMTILGAKFQKIAISSLKRALKTINGVPQTSGGRTPSSSITEFISGDDASPCLPIPGADKPIFIREDDFGFMTTSGHMDEENHLIPEYDVISGSSRSTSSSPPSLESRSQAMDTEEITEGAGSALFNLLSNHLNYPKGLSPDTPLGALGLDSLVAIQLQSDIEQMFGKNSQLMDINESSTFSTLFHTIFPQQQTDQFGFVPLHDQTGKDRLESAVPLRLGYSHIKHAAPSFNDSLDRSNTLFIRQVPHAMDALKQNISSTIKAAGFHDFFSDVHPRQRSLVLAYIVHAFRELGCDIRSLEVGDELPSVQFKPKYQNVMNRLFDILGSEGVINVLNKRYLGGLASFPERSAEDMHKAIMNDYPSYHPDHKLLHTTGARLADCISGKVDPLQILFQNATSIKLLEDVYVKSPMFGTGNLLLGEFMNCLFSYNKTPDRLNHIRILEIGAGTGATTQLVVDRLLACNVDFTYTFTDVSAALVASAREKLTSRYGQHQRFDMEFETLNIEKEPPASFAQSYDLVISANCIHATRDLRKSCSNIEKLLRKDGGVLCLLELTRPLEWLDCVFGLLDGWWRFDDHRTYALAGEQDWKTILLQSGFGHVDWTDDGSREAQQLRLITAWR
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the immunosuppressants subglutinols, meroterpenoids consisting of an alpha-pyrone (4-hydroxy-5,6-dimethyl-2-pyrone) moiety attached to a decalin core fused to a five-membered cyclic ether carrying a prenylside chain (PubMed:27189118).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase subA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:27189118).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase subD through the action of the prenyltransferase subC to yield a linear alpha-pyrone diterpenoid (PubMed:27189118).  Subsequent steps in the subglutinol biosynthetic pathway involve the decalin core formation, which is thought to be initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase subE (Probable).  The following cyclization cascade would be catalyzed by the terpene cyclase subB (Probable).  Lastly, the FAD-dependent dehydrogenase subF probably catalyzes the five-membered cyclic ether formation to complete the formation of subglutinol A (Probable).  Subsequent redox reactions appear to give rise to subglutinol C and D, however, it remains unclear which enzymes are responsible for these transformations (Probable).  SubD may have secondary function in the conversion of the identified subglutinols to subglutinol analog 45, which seems to be the major product of the cluster (PubMed:34863012).
What are the official names of this protein?
Non-reducing polyketide synthase subA, Subglutinol biosynthesis cluster protein A.