PharMolix/UniProtQA huggingface dataset:
Protein: RN123_HUMAN
Sequence: MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA
What is the function of this protein?
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase.  Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581).  Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109).  Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF123, Kip1 ubiquitination-promoting complex protein 1, RING finger protein 123, RING-type E3 ubiquitin transferase RNF123.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_BRUC2
Sequence: MGSFSIWHWLIVLAVVLLLFGRGKIPELMGDVAKGIKNFKQGMADEDAKEDPRTIDAKAEEPVKDVKKTTKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RS13_FRATM
Sequence: MARIAGVNIPVHKHTVIGLTSIYGIGKTRAQQICQTCNVDPTVKIKDLSEEQVESLRTEVAKFTVEGDLRREVSMDIKRLMDLGCFRGRRHRRSLPVRGQRTKTNARTRKGPRKPIKA
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: Y2043_STAHJ
Sequence: MAEDKFEQAKGNLKETVGNVTDNKDLEKEGQNDKASGKAKEAVENVKNKANDLIDKVKGNNDNK
What are the official names of this protein?
UPF0337 protein SH2043.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: BP11C_CROVV
Sequence: QSAPGNEAIPP
What is the function of this protein?
This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it.  It acts as an indirect hypotensive agent (By similarity).
What are the official names of this protein?
Bradykinin-potentiating peptide 11c, BPP-11c.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: GN_EHV2
Sequence: MAPGRGVLLLICLCLMDNVSQVVCSQNSTTPSKFPTFYSYDCNADTYAPQLTSFSTIWTLLNVLVMTIACVIYLIYMCFNKFVATMTNT
What is the function of this protein?
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity.  Also plays a critical role in virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein N.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein N family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Protein: RCSA_ECO57
Sequence: MSTIIMDLCSYTRLGLTGYLLSRGVKKREINDIETVDDLAIACDSQRPSVVFINEDCFIHDASNSQRIKLIINQHPNTLFIVFMAIANVHFDEYLLVRKNLLISSKSIKPESLDDILGDILKKETTITSFLNMPTLSLSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHNKQVIYHVVRLTDNVTNGIFVNMR
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  Binds, with RcsB, to the RcsAB box to regulate expression of genes.
What are the official names of this protein?
Transcriptional regulatory protein RcsA.
What is the protein family that this protein belongs to?
Belongs to the RcsA family.
Protein: DTD_DESHD
Sequence: MRSVVQRVTQASVTVEGEVVGRIGAGLLVLFGVGRGDTEADLNWMVDKIAGLRLFEDGEGKMNRSVQDVGGEILMVSQFTLYGDCRKGKRPSFATAAPPETAGELFQQAVAKMRGYGLHVETGVFQAEMQVALVNDGPVTLLIDSEKNF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_KOSOT
Sequence: MRFNLKAPFEPRGDQPEAITRLVEGLRRGDRFQTLLGVTGSGKTFTMASIIERVQQPALVISPNKALVAQLYREFRSFFPENRVELFISYYDYYQPEAYIPTKDLYIEKDADINDLLARMRISALKSVLTRKDVVVVASVSAIYASGDPRDFQELNISLEIGQRIPRNELALKLASIQYSRSEDISSGGVFHLRGDVVEIFPPYEDYGIRIYFFDDEIERIISFDPMNRKTLEEFDRIIIYPAKEFVTTEEKIKHAVKEIERDLELRAKELEKNGKYLEAQRLKQRTLYDLEMLTTLGYCSGIENYSRYFDGRKPGEPPYTILDYFDKSEMIVFLDESHITVPQIRAMYHGDHSRKKNLVEYGFRLPSAFDNRPLTFEEFLESVGQIIFVSATPGDYELSVSTQIVEQLIRPTGLIDPEVVVKPTQNQVDDFIEEVQKVIERGERALVTVLTKKAAEMFSAYLNELGIRAEYLHSELDTVERVEVLKKLREGSVDVVVGVNLLREGLDLPEVSLVAIMDADKEGFLRSETTLIQTIGRAARNINGKVLLYADRITNSMKRAIEETNRRRMKQLMYNIEHDIKPESIVKPLYENIFEEFADNEEKIEIAKNTYLDGILALKEDLEAEEYLALLEEEMWRASSELRYEDAAMLRDEMLRIKRETKKDNI
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCAF8_RAT
Sequence: MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQVGQEKDVCAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTVAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFNKKLMDRFDFGEDSEHSEESKKEIPTPQLSHVSESVNNSIFHQIAEQLQQQNLEQLRQQLLEQQQPQKVTPQDSQEGAFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEGQDVVEEEIFEPEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLDGFAEGGMIDQETVNAEWETVKTSEPVKETVQTTQSPAAVEKETVVTTQSEVFPPPVTMLQIPVAPTVPAVSLVPPAFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPAIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVAGNLAPSTLPAGNVFNPPSKAEPEEKVPHLTEHQIPSGENTRPVIPSDIPSSAPMLAQPPGASNTSGILCVQRPNVSSNSEILGVRPANVSNSAAIMGAQPPNMLNNSGILGIQPPNVSSGSGLLGVLPPNLPNNSGLVGLQPPNVTNPAGLLGTQPPIGPQNLPPLTIPAQRMPALPMLDIRPGLIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFPPGDLFSQPERPFLAPGRPNIDSVPNPDKRIPLGNDNIQQEGDRDYRFPPIETREGINRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDMRETLVRPGLDHLGRRDHFGFPPEKPWGPRDFDEREHRVLPVFGGPKGLHEERGRFRAGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREINGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGENVPQVNGGNTERHAPPPPLPVQKDPELYEKLASSGDADKEESGTAAGVESEAVVESTETEGT
What is the function of this protein?
Anti-terminator protein required to prevent early mRNA termination during transcription.  Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins.  Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation.  Independently of SCAF4, also acts as a positive regulator of transcript elongation.
What are the official names of this protein?
SR-related and CTD-associated factor 8, RNA-binding motif protein 16.
What are the subcellular locations of this protein?
Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription.
Protein: ISPH_CAUVC
Sequence: MNAQTPIRRPISLVLASPRGFCAGVDRAIQIVERAVEKFGAPVYVRHEIVHNRHVVDRLKALGAVFIEELEEAPDDRPVVFSAHGVPKSVPAEAKARQMIYLDATCPLVSKVHVEAQKHYDAGREIVLIGHAGHPEVIGTMGQLPEGAVTLIEDLKDAAAWEPKDAANVAFLTQTTLSVDDTADMVALLRERFPGIAAPHKEDICYATTNRQDAVKHLAEQSELILVVGSKNSSNSVRLKEVGLKAGARDAHLIDDASGIDWTWFDGISRVGLTAGASAPEDLVQGVIDAISARFDTTVEELVEARETITFKLPRLLTA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: SSRA_ARATH
Sequence: MMNLRVLFLALLLLASPLLQVARCQSDAEDHSSLVDDVVGENTDDAVEEDDHDLDMNLSSFPGVETVCVFPKNSAKLVPAGEETELLVGLKNEGKTRVGVMGIRASVHLPYDHKLLVQNLTMLRLNNASIPTSLQATFPYIFAVSQYLQPGAFDLVGYIIYDVEGKPYQSVFYNGTIEVVESGGLLSGESVFLLTLGIGLLLLLGLWAYSQVQRLTKKTKKVSKVEVGTRSTEASLDEWLEGTTLAKTSSGKTKNKKN
What is the function of this protein?
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.  May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
What are the official names of this protein?
Translocon-associated protein subunit alpha, TRAP-alpha, Signal sequence receptor subunit alpha, SSR-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAP-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y2918_BACLD
Sequence: MKEETFYLVREDVLPEAMRKTLEVKKLIERKKAESVAEAVQKVDLSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGTLSHLLQVVAESGCNVLSIHQTIPLQGRANVTLSVSTRGMDENIDLLMNKLRKLEFVEKVEILGSGA
What are the official names of this protein?
UPF0735 ACT domain-containing protein BLi02918/BL01157.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: PG137_VACCA
Sequence: MTTVPVTDIQNDLITEFSEDNYPSNKNYEITLRQMSILTHVNNVVDREHNAAVVSSPEEISSQLNEDLFPDDDSPATIIERVQPHTTIIDDTPPPTFRRELLISEQRQQREKRFNITVSKNAEAIMESRSMISSMPTQTPSLGVVYDKDKRIQMLEDEVVNLRNQRSNTKSSDNLDNFTRILFGKTPYKSTEVNKRIAIVNYANLNGSPLSVEDLDVCSEDEIDRIYKTIKQYHESRKRKIIVTNVIIIVINIIEQALLKLGFEEIKGLSTDITSEIIDVEIGDDCDAVASKLGIGNSPVLNIVLFILKIFVKRIKII
What is the function of this protein?
Required for viral crescent formation early during virus morphogenesis.
What are the official names of this protein?
Protein OPG137.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG137 family.
Protein: RL11_LEUMM
Sequence: MAKKVVNVVKLQIAAAKATPAPPVGPALGQAGINIAQFTKEFNARTADQAGSIIPVEISVFDDRSFEFVTKTPPAADQLRKIVGKGSGEPNTKKAGNVTLDQIRAIAENKMSDLNANDITNAMRMIEGTARSMGVTVDGVDLTVEGTAIKEDAE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PROS_RABIT
Sequence: GHASQVLVRKRRANSMLEETKKGNLERECIEELCNKEEAREVFENDPETDYFYPKYLGCLGSFRAKLFTATRRSANGYPDLRSCVNAIPDQCNPLPCSEEGYLNCKDGQATFTCICKPGWQGEKCEIDINECKDPTNINGGCSQICDNTAGSYHCSCKSGFVMLANEKDCKDMDECSVKPSVCGTAVCKNTPGDFECECSEGYRYNPTAKSCEDIDECSENMCAQLCVNYPGGYSCYCDGKKGFKLAQDKKSCEAVPVCLPLDLDKNYQLLYLAEQFVGAVLYLKFHLPEITRFSAEFDFRTYDSEGVILYAESLDHSTWFLIALRQGKIEIQFKNDYAAQITTGGQVINDGLWNMVSVEELEHSVSIKIAQEPVMNINKPGSLFKPTNGFLETKVYFAGLPRKVENALIRPINPRLDGCMRGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQFHIDYNNLSYVEDWQVNVTLNIRPSTGTGVMLTLVSGNTLPFALSLVQSTSETSQDILVSVENRVIYQLESISLCSGQQSQLEFSVSRNHLELSTPLVKDVIYSEDLQRHLAVLDEAMKGTVTTYLGGLPEVPFNATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWNDKTNS
What is the function of this protein?
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa.  It helps to prevent coagulation and stimulating fibrinolysis.
What are the official names of this protein?
Vitamin K-dependent protein S.
What are the subcellular locations of this protein?
Secreted.
Protein: TYSY_FRATT
Sequence: MQEYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTNMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_MYCFE
Sequence: MQPQGKMKKPTAEHMINENIPFQKVFVIGANGEKVGVLSTREAIEMAKEQRLDLVLISVQPKPIARILDYGKFKYERKKKQKAAKEKQTVIQNRQIRLTPLIGEHDLNVKARKAKEFLLDGDRIKVSLKFRGRESARPELGHKTLEKFYKAVEDLADIAKEAELVNDRFLDMYLQPNKIKVNKYRKEHNLVDKNSDSQDKSVSEEDTNEGEQ
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LY6H_MOUSE
Sequence: MLPAAMKSLGLALLALLLCPSPAHGLWCQDCTLANSSHCAPKQCQPTDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCCEKDLCNGASVAGRSPWALAGGLLLSLGPALLWAGP
What is the function of this protein?
Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity.  In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.  In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394).  May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:25716842).  Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity).
What are the official names of this protein?
Lymphocyte antigen 6H, Ly-6H.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CH601_VIBC3
Sequence: MAAKHVLFSTDARQKMLSGVNLLANAVKVTLGPKGRHVVLNKSYGAPTITKDGVSVAKEIELADKFENMGAQMLKQVASKANDEAGDGTTTATVLAQALINEGMKAVAAGMNPMDLKRGIDKAVSAAVEKLHQLAKPCSDTQSITQVGAISANSDHAIGEIIAQAMEKVGRNGVITVEEGQALQNELSVVEGMQFDRGYLSPYFINQPKAGCVELENPYVLLVDKKISHIRELLPILESVAKASRSLLIIAEDVDGDALATLVVNSMRGIIKVAAVKAPGFGEQRKAMLEDIAALTAGRVISEEIGLELEKVTLDDLGSAKKVTINKDNTTIVDGAAEPSALQDRIAQIQHQLEHTTSQYDRDKLQQRIAKLSGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALLKIANELSNLQGDNDDQNVGIRIALRAMEEPLRQIAINAGDEASVIANQVKTGDEHYGYNAATGQFGNMLEMGILDPAKVTRSALQFAASIAGLMITTEAMVSEVDKESAA
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAL_MICAN
Sequence: MAETGYKQVVTPYNDDPFIGHLATPISASGFTKAFIGNLPAYRPGLAPILRGLEVGMAHGYFLGGPWVVLGPLRDSEYANIGGLIPALAMVLLATGCLASYGLVSFQGKAASNDPLKSAEGWSQFAAGFFIGGMGGAFVAYFLLENLGVVDGIMRGVFNQ
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RNFB_TOLAT
Sequence: MNHILLIILIFAALALIFGLLLGFAAIHFKVESDPIVDQLDALLPQTQCGQCGYPGCRPYAEAIANGDSINKCVPGGAQTIQNIADLMGVEPPSDDNELLMAPPKRVAFIHENLCIGCTKCIQACPVDAIIGAPKLMHTILRSECTGCDLCVDPCPTNCIEMIELPATPDRWKWDVETIPVRMVQ
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: VL2_HPV6B
Sequence: MAHSRARRRKRASATQLYQTCKLTGTCPPDVIPKVEHNTIADQILKWGSLGVFFGGLGIGTGSGTGGRTGYVPLQTSAKPSITSGPMARPPVVVEPVAPSDPSIVSLIEESAIINAGAPEIVPPAHGGFTITSSETTTPAILDVSVTSHTTTSIFRNPVFTEPSVTQPQPPVEANGHILISAPTVTSHPIEEIPLDTFVVSSSDSGPTSSTPVPGTAPRPRVGLYSRALHQVQVTDPAFLSTPQRLITYDNPVYEGEDVSVQFSHDSIHNAPDEAFMDIIRLHRPAIASRRGLVRYSRIGQRGSMHTRSGKHIGARIHYFYDISPIAQAAEEIEMHPLVAAQDDTFDIYAESFEPGINPTQHPVTNISDTYLTSTPNTVTQPWGNTTVPLSLPNDLFLQSGPDITFPTAPMGTPFSPVTPALPTGPVFITGSGFYLHPAWYFARKRRKRIPLFFSDVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: AROK_CHLL3
Sequence: MGQDTITKQHSLIFLTGFSGSGKSTIGPLLANSLGYEFLDVDQAVEQRAGKPITRIFAEEGEAAFRELELQTLKTVAGEKEMVVSLGGGALQYDPSHAFIAGAGTLVYLKSSAANLAKRLVNKRDRPLLRGENGRKHSREELEEKIRRILEEREPRYQQAALTVQTDQKRIGSTVEELTRKIERLVRKAPQIGEDGQQPEQP
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_HALMA
Sequence: MTSKKKRQRGSRTHGGGSHKNRRGAGHRGGRGDAGRDKHEFHNHEPLGKSGFKRPQKVQEEAATIDVREIDENVTLLAADDVAEVEDGGFRVDVRDVVEEADDADYVKVLGAGQVRHELTLIADDFSEGAREKVEGAGGSVELTDLGEERQAEAEETEDADADEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15, Hl9, Hmal15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: M890_ARATH
Sequence: MHLERSVQSQLTESKEIARPYSLWGISLAQHSFKTSTRSTGKKRSKGSTSQDGKKQESLESRNDLGPTIVGLIRKILSYSSKKEFSNLTGLESGGSSPPFSLAVSK
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg00890, ORF106d.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UPPP_STRP1
Sequence: MLIIELLKAIFFGIIEGITEWLPVSSTGHLILVQEFIRLNQDKAFIEMFNIVIQLGAIIAVMLIYFERLNPFQPGKTAREVQLTWQLWLKVVIACIPSILIAVPLDNWFEAHFYFMVPIAIALIVYGIAFIWIEKRNAQQEPAVTELARMSYKTAFFIGCFQVLSIVPGTSRSGATILGAIILGTSRTVAADFTFFLAIPTMFGYSGLKAVKFFLDGHHLDFAQVLILLVASLTAFVVSLLAIRFLTDYVKKHDFTIFGKYRIVLGSLLLIYSFFKFVF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.