PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_ORITB
Sequence: MKNQLLDAKVASEEQETVLRPSLLNDFIGQNQMKSNLTIFITSSIERDESLDHTLLHGPPGLGKTSIAQIIAKEKNVNLKSTAGPILSKAADLAAILTNLQKNDVLFIDEIHRLNIHVEEILYSAMEDFSLDIMIGEGPSARSVKIYLPKFTLIGATTRLGLISKPLCDRFGIHLKLNFYSCEELTQIVERGAKVLNVALDTNAAIEIANRSRGTPRIALRLLKRVRDFGIYQNINPLNQQITDYALNQLGIDKLGLDSSDHKYLRFIAENYDGGPVGIDTIAAALSEQRDTIEEMIEPYLIQIGFVQRTQRGRVITANALKHLH
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AROA_MYCLE
Sequence: MSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQGTSTIGGALRSRDTELMISALRTLGLHVDEAGSVLTVNGRITPGEDAQVDCGLAGTVLRFVPPLAALSANPVTFDGDEQARARPITPLLDALRGLGVPVDGVGLPFQVQGSGSVAGGTVAIDASASSQFVSGLLLCAASFTQGVTVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGNRWQVRPGTVAARHWVVEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFRLNVVVNQTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIAHLRGHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHRMAMAGAIVGLRVSGVEVDDIGATHKTLPQFPQLWANMLKRSTG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CAEEL
Sequence: MVGKRNLPVISRNFDLSPGVLRFSASRLRLKKGEKKPKFTKDTSAKLPKLQRNGTKFALGHSKTVTLRKTLTPGTVLIVLAGRHKGKRVVFLKQLPQSGLLLVTGPHKINGFPLRRIGQAFVIATSLKVNVSGVKIPEHINDEYFKRKSTAQKTGKNIFASGKTEYTVSEQRKKDIKTVDAPILAAIKKHPEHKFLFGYLGTRFSLGKNQYPHKMQF
What is the function of this protein?
Component of the large ribosomal subunit.
What are the official names of this protein?
60S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL6 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: DPOE3_DROME
Sequence: MVERIEDLNLPNAVIGRLIKEALPESASVSKEARAAIARAASVFAIFVTSSSTALAHKQNHKTITAKDILQTLTELDFESFVPSLTQDLEVYRKVVKEKKESKASKKDSNTAENANASATATAEEAPE
What is the function of this protein?
Accessory component of the DNA polymerase epsilon complex (By similarity).  Participates in DNA repair and in chromosomal DNA replication (By similarity).  Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes (PubMed:10856248, PubMed:11447119, PubMed:18327268).  Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin (PubMed:10856248, PubMed:11447119).  As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf (PubMed:16260604).  Has a role in DNA damage response by preventing cid mislocalization to chromatin (PubMed:24703848).
What are the official names of this protein?
DNA polymerase epsilon subunit 3, Chromatin accessibility complex 14kD protein, Histone-fold protein CHRAC subunit.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCA_HALHL
Sequence: MERYRVGGAVRDRLLGRPVDEVDWVVVGATPEAMEAAGYRPVGKDFPVFLHPQTGEEHALARTERKTAVGYHGFEFYAAPEVTLEQDLARRDLTINAMAEDAGGRLIDPFGGQVDLQARQLRHVTDAFAEDPVRILRLARFAARFADDGFVVADETMALCQRMVAAGEVDALVPERVWQELARGLMEPTPRRMIEVLRQAGALARLLPEVDALFGVPQSPAHHPEGDAGTHTLMALDAAAAVDASLEARFAVLLHDVGKALTPAEALPRHPGHEEAGVDGARRVSERLKAPRACRDLAVLVTRWHMHAHRALELRPGTVVELFEGLDLFRRPERLEPFLHACLADDRGRGGREASDWPAGDFLRAAFEACRGVSARSFVEQGLRGPEVGEAVREARCRAVAQVPRPDAGAARDGA
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: MURG_ANAD2
Sequence: MRMMVAGGGTGGHVFPGIALAEEVVTRHPANDVVFVGTARGLEASVVPAAGFPIELIEVKGLKGKGIAGALLNLLLLPRAFLQSWRILRRWRPDVVVGVGGYASGPVVLTAWAMRIPTAVQEQNAIAGLTNRLLGRVVKAAFTAFPEAARHFAARKVYQLGNPIRRRLMENYMRPESAHGQPRLLVFGGSQGAHALNMRVIEALPHLADLRERIQITHQTGARDREYVEKGYRACGFTPDVREFIDDMSAAYAGCDLVVCRAGATTLAELTVCKKPSILVPFPAAADNHQVKNARSLVDAGAAVMIEERDLTGEVLAREIREILDAPERRERMARAAGRLGSPQAAKEIADVCMELVRRRWGSPFGQAREPGQKPARPPDPAS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MIAB_BRUSI
Sequence: MSDDTTQIEPAMAQETSPRANTRKVFVKTYGCQMNVYDSQRMADSLAAEGYVATDTPDDADLVLLNTCHIREKASEKLYSALGRLRKMKDARAADGKELTIGVAGCVAQAEGQEILRRAPNVDLVIGPQTYHRLPNALARVRGGEKVVETDYAIEDKFEHLPAPRREETRKRGVSAFLTVQEGCDKFCTFCVVPYTRGSEVSRSVKQIVAEAERLADSGVRELTLLGQNVNAWHGEGEDGREWGLGELLFRLARIPGIARLRYTTSHPRDMDDSLIAAHRDLRQLMPYLHLPVQSGSDRILKAMNRRHKADEYLRLIERIRNVRPDMALSGDFIVGFPGETDQDFEDTMQLVRDVNYAQAYSFKYSPRLGTPGADLDDHVEEAVKDERLQRLQALLSAQQYAFQDSMIGRKMDVLLEKPGREAGQMVGRSPWLLPVIIDDNKDRVGDIIHVKIVSTGTNSLIAQKLA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_ESCF3
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWFCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLRDVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAEETELQTLLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGEYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: Y1216_LISMF
Sequence: MLKTEHISFQYEDGKQALTDVSIDLEKGNIIGLIGANGSGKSTLFMQLLGINKPSDGTVYFEGKPLAYTKKALFALRKKVSIVFQDPDQQIFYSNVRDDVAFALRNLGVSETEVEARVTKVLDIVGAKDFQHKPVQYLSYGQKKRVAIAGALVLDTDWLLLDEPTAGLDPIGKKIMMEIIERLASQGKKILISSHDIDLIYEICDYVYMLKDGSVLTDGETSNVFLEKSNVEQAGLVQPWLIKLHQQAGYPLFKKEADFFAHTGKVTN
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein LMOf2365_1216.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YDGJ_ECOLI
Sequence: MSDNIRVGLIGYGYASKTFHAPLIAGTPGQELAVISSSDETKVKADWPTVTVVSEPKHLFNDPNIDLIVIPTPNDTHFPLAKAALEAGKHVVVDKPFTVTLSQARELDALAKSLGRVLSVFHNRRWDSDFLTLKGLLAEGVLGEVAYFESHFDRFRPQVRDRWREQGGPGSGIWYDLAPHLLDQAITLFGLPVSMTVDLAQLRPGAQSTDYFHAILSYPQRRVILHGTMLAAAESARYIVHGSRGSYVKYGLDPQEERLKNGERLPQEDWGYDMRDGVLTRVEGEERVEETLLTVPGNYPAYYAAIRDALNGDGENPVPASQAIQVMELIELGIESAKHRATLCLA
What are the official names of this protein?
Uncharacterized oxidoreductase YdgJ.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: BPHD_PSES1
Sequence: MSELNESSTSKFVTINEKGLSNFRIHLNDAGQGERVIMLHGGGPGAGGWSNYYRNIGPFVEAGYRVLLPDAPGFNKSDTVVMDEQRGLVNARSVKGMMDVLGIEKAHLVGNSMGGAGALNFALEYPERTGKLILMGPGGLGNSLFTAMPMEGIKLLFKLYAEPSLETLKQMLNVFLFDQSVITDELLQGRWANIQRNPEHLKNFILSAQKVPLSAWDVSARLGEIKAKTLVTWGRDDRFVPLDHGLKLIANMQDAHVHVFPRCAHWAQWEHADAFNRLTLDFLANG
What is the function of this protein?
Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).
What are the official names of this protein?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, HOPDA hydrolase, 2,6-dioxo-6-phenylhexa-3-enoate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. BphD family.
Protein: RS21_BUCAT
Sequence: MPIIKVRENEPFDVALRRFKRSCEKAGILAEIRRREFYEKPTTERKRAKASAVKRLAKKLTRENARRIRMY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: LIPB_SHEPC
Sequence: MPLQDTTLHIRHLGKQDYESVWHAMQHYTDTRNSESPDELWIVEHPPVFTQGQAGKSEHILNAGDIPVIQVDRGGQVTYHGPGQLVVYPLIDIKRSKIGVRQLVTHIEQSIINMLAKYDIQAYAKADAPGVYVNERKIASLGLRIRRGCSFHGLALNVDMDLAPFRRINPCGYAGLEMVQSKALGGPQTVTEAGEQLTITFSQLLGYQHLVHHQGLAAS
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTC1_BACMK
Sequence: MMAIQNREEFLLQLSEKLGRKRPEAVEKPKWSFSPQWNVFDGLAQDELVLQLMEHCEVIHTEVKRTTKENLVETLGSLIKEWNIKSAMYSNDERFNEYGLTSCFNNEGTTHFRAWGLGDKEEDIKFAKAADLGITFSDMTLAESGTVVLFNDGLKGRHVSLLPESYIAIVPKSTIVPRLTQATKLIHNQSKAGENLPACVNFVSGPSNSADIEMNLVVGVHGPIRTAYIIVDDQ
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C 1.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: AROD_BACSU
Sequence: MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDIVEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLESAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRKMQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEVFGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: RPOC1_SYNE7
Sequence: MAKQEQRFDYVKIALASPERIRQWGERTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPAKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVAHVWYLKGIPSYIAILLDMPLRDVEQIVYFNSYVVLNPGNHSELQYKQLLNEDQWMEIEDQIYAEESDLEGIEVGIGAEALQQLLQDLNLNEESEKLRQEIAESKGQKRAKLIKRLRVIDNFIGTESRPEWMVLNVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPNLKIHQCGLPREMAIELFQPFVIHRLIKNHSINNIKQAKKLIQKNDPLIWDVLEEVIEGHPVMLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSIEAQAEARMLMLASGNILSPATGQPIVTPSQDMVLGCYYLTAENPGAQKGAGRYFANLEDAIRAFEQGSVDLHAWVWVRFDGEVESEGESDEPESVVAADDGTVTKTYRFRRIRETEDGQRLSQYVKTTPGRILFNNTVQTALIH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: PETH1_THEFU
Sequence: MPPHAARPGPAQNRRGRAMAVITPRRERSSLLSRALRFTAAAATALVTAVSLAAPAHAANPYERGPNPTDALLEARSGPFSVSEERASRFGADGFGGGTIYYPRENNTYGAVAISPGYTGTQASVAWLGERIASHGFVVITIDTNTTLDQPDSRARQLNAALDYMINDASSAVRSRIDSSRLAVMGHSMGGGGTLRLASQRPDLKAAIPLTPWHLNKNWSSVRVPTLIIGADLDTIAPVLTHARPFYNSLPTSISKAYLELDGATHFAPNIPNKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYRSTCPF
What is the function of this protein?
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle (Probable).  Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters) (PubMed:23604968, PubMed:25545638).  Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world (PubMed:25545638, PubMed:32269349).
What are the official names of this protein?
Cutinase cut1, Poly(ethylene terephthalate) hydrolase, PET hydrolase, PETase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted. Periplasm.
Protein: DBP10_YEAST
Sequence: MAGVQKRKRDLEDQDDNGSEEDDIAFDIANEIALNDSESDANDSDSEVEADYGPNDVQDVIEYSSDEEEGVNNKKKAENKDIKKKKNSKKEIAAFPMLEMSDDENNASGKTQTGDDEDDVNEYFSTNNLEKTKHKKGSFPSFGLSKIVLNNIKRKGFRQPTPIQRKTIPLILQSRDIVGMARTGSGKTAAFILPMVEKLKSHSGKIGARAVILSPSRELAMQTFNVFKDFARGTELRSVLLTGGDSLEEQFGMMMTNPDVIIATPGRFLHLKVEMNLDLKSVEYVVFDEADRLFEMGFQEQLNELLASLPTTRQTLLFSATLPNSLVDFVKAGLVNPVLVRLDAETKVSENLEMLFLSSKNADREANLLYILQEIIKIPLATSEQLQKLQNSNNEADSDSDDENDRQKKRRNFKKEKFRKQKMPAANELPSEKATILFVPTRHHVEYISQLLRDCGYLISYIYGTLDQHARKRQLYNFRAGLTSILVVTDVAARGVDIPMLANVINYTLPGSSKIFVHRVGRTARAGNKGWAYSIVAENELPYLLDLELFLGKKILLTPMYDSLVDVMKKRWIDEGKPEYQFQPPKLSYTKRLVLGSCPRLDVEGLGDLYKNLMSSNFDLQLAKKTAMKAEKLYYRTRTSASPESLKRSKEIISSGWDAQNAFFGKNEEKEKLDFLAKLQNRRNKETVFEFTRNPDDEMAVFMKRRRKQLAPIQRKATERRELLEKERMAGLSHSIEDEILKGDDGETGYTVSEDALKEFEDADQLLEAQENENKKKKKPKSFKDPTFFLSHYAPAGDIQDKQLQITNGFANDAAQAAYDLNSDDKVQVHKQTATVKWDKKRKKYVNTQGIDNKKYIIGESGQKIAASFRSGRFDDWSKARNLKPLKVGSRETSIPSNLLEDPSQGPAANGRTVRGKFKHKQMKAPKMPDKHRDNYYSQKKKVEKALQSGISVKGYNNAPGLRSELKSTEQIRKDRIIAEKKRAKNARPSKKRKF
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10, DEAD box protein 10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TLG1_YEAST
Sequence: MNNSEDPFQQVVKDTKEQLNRINNYITRHNTAGDDDQEEEIQDILKDVEETIVDLDRSIIVMKRDENEDVSGREAQVKNIKQQLDALKLRFDRRIQESTQTTIPLEETVENSTLNTSMAENNDGGMSNPFQEQMLREQDVHLDGIHKTMQNLHIQAQTMGDELENQGQLLDNMDEGMDGVVNKLARGRRQLEWVYEKNKEKYDDCCIGLLIVVLIVLLVLAFIA
What is the function of this protein?
SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi).  It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE.  Upon vesicle tethering to the target membrane, which requires additional proteins, a SNARE-pin is formed.  This is a very stable 4 parallel alpha-helical coil bundle consisting of 4 SNARE domains (usually one of each type: Qa, Qb, Qc, and R), of which at least one is anchored in the opposite membrane.  The formation of the SNARE-pin is believed to bring the two membranes in close proximity and to provide the energy to drive membrane fusion.  Through its interaction with the VFT (or GARP) complex, it may also contribute to vesicle recognition specificity and tethering.  Regulation of SNARE-pin formation also seems to depend on the phosphorylation state of the protein, phosphorylation by TPK1 causing inhibition and dephosphorylation by SIT4 activation.
What are the official names of this protein?
t-SNARE affecting a late Golgi compartment protein 1, Syntaxin TLG1.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single- pass type IV membrane protein. Note=Probably shuttling between TGN and early/late endosome.
Protein: MATR3_RAT
Sequence: MSKSFQQSSLGRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDTDQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDEKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDGAQKTENPAEGKEQEEKSGEDGEKDTKDDQTEQEPSMLLESEDELLVDEEEAAALIESGSSVGDETDLANLGDVSSDGKKEPSDKAVKKDASATSKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESAENADDPNKDASDNSDGQNDENKEDYTIPDEYRIGPYQPNVPGGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKES
What is the function of this protein?
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.  In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.  Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs.  May bind to specific miRNA hairpins.
What are the official names of this protein?
Matrin-3, Nuclear scaffold protein p130/MAT3.
What are the subcellular locations of this protein?
Nucleus matrix.
Protein: RL5_CHLFF
Sequence: MSRLKKLYTEEIRKSLQEKFGYTNTMQIPVLKKIVISMGLAEAAKDKNLFQAHLEELSMISGQKPLVTKARNSIAGFKLREGQGIGAKVTLRGERMYDFMDRFCNIVSPRIRDFRGFSKKGDGRGCYSLGLEDQQIFPEVDLDRVKRTQGMNITWVTTAQTDAECTTLLELMGLRFKKAQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: HKT11_ORYSJ
Sequence: MHPPSLVLDTLKRIKLYIAMKLLLPNSEVPRIYWEKAQHLCGFLSMKLISRARCVASSVKQSYSFLVCKSNPLVVQLVYFVIISFAGFLALKNLKPQGKPGPKDLDLLFTSVSTLTVSSMATVEMEDLSDRQLWVLILLMLMGGEVFTSMLGLYFNNANANRNENSQRSLPSISLDIEFNSPANNGDHKITECGQSEETMSQNQVQQNKSITYNPCAVLVRIVTGYFVATVISSSVIIIIYFWIDSDARNVLKSKEINMYTFCIFTAVSSFANCGFTPLNSNMQPFRKNWVLLLLVIPQILAGNTLFSPLLRLCVWVLGKVSGKAEYAYILQHPGETGYKHLHVRRNSVYIVLSVTGLILLQVMFICSFEWNSESLEGMNWLQKLVGLLFQSVNTRQAGESILDISTLSPSTLLLFAVVMYLPSDASFLTANADNQPLTDKKTNSISRALWRNFTVNKLSCLAMFTFLACITERKSISSDPLNFNIFSIVFEIISAFGNVGYSLGYSCQKLLKPDATCKDASYGFVGRWTEEGKLIVILVMFLGRLKEFILK
What is the function of this protein?
Functions as a low-affinity sodium transporter.
What are the official names of this protein?
Cation transporter HKT1;1, OsHKT1;1, Cation transporter HKT4, OsHKT4.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family. HKT (TC 2.A.38.3) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LOLD_PASMU
Sequence: MKSHLLHCQHITKYYQEGSQQTQVLKDVSFSMQAGELVAIVGSSGSGKSTLLHVLGGLDQPTSGEVFIQNQSLQKINANQLAQLRNQYLGFVYQFHHLMADFSALENVMMPMLIGKQNRSEAQDRAEKMLTAVGLSHRISHRPSALSGGERQRVAIARSLVNHPALVLADEPTGNLDRKTTESIFDLIKQLNQEQNIAFLLVTHDLTLAEKLSRRLVMQDGVLREEH
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.