PharMolix/UniProtQA huggingface dataset:
Protein: MSHR_HYLLA
Sequence: MAVQGFQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSIPDGLFLSLGLVSLVENVLVVATIAKNRNLHSPTYCFICCLALSDLLVSGGNVLETVVILLLEASALAARAAVVQPLDNVIDVITCSSMVSSLCFLGAIAMDRYVSIFYALRYHSIVTLPRARQAIAAIWVASVLFSTLFIAYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPLHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPQHPTCSCIFKNFNLFLTLIICNAIIDPLIYAFRRQELRRTLKEGLTCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATK_POAPR
Sequence: MEKFEGYSEKHKSRQQYFVYPLLFQEYIYAFAHDYGLNDSEPVEIVSRNNKKFSSLLVKRLIIRMYQQNFGINLVNHPNQDRLLDYKIGFYSEFYSQILSEGFAIVVEIPFSLRELPCPKEKEIPKFQNLRSIHSIFPFLEDTFLHLDYLSHIEIPYPIHLEILVQLLQYRIQDVPSLHLLRFFLNYYSNWNSFITSMKSIFIFKKENKRLFRFLYNSYLSEYEFFLLFLRKQSSCLPLASSGTFLERIHFSRKMEHFGIMYPGFFRKTIWFFMDPLMHYVRYQGKAIFASKGTLFFNKKWKWYLIHLWQYFFSFWTQPRRIHLNQLANSCFDFMGYLSSVPKSPLLVRNQMLENSFLIDTRMPKFDTIVPVTALIGYLSKAQFCTGSGHPISKPIWTDLSDWDILDRFGRICRNLFHYHSGSSKKRTLYRLKYILRLSCARTLARKHKSTVRTFMQRLGSAFLEEFFTEEELVFSLMFTKTTLFSFCGSHSERIWYFDIIRINDLVKPLN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MURB_RHILO
Sequence: MHGQALIDRLGDRLAGLRGRLTPNAEMDKITWFRAGGLAEVFFQPADEEDLAAFLRAVPEEIPLTIVGVGSNLLVRDGGIPGFVIRLSAKGFGEAEIVSPIRIKAGAATPDKRVAALALEAGIGGFHFYHGIPGAIGGALRMNAGANGVETRERVVEVRALDRKGNVQTMSNAEMGYAYRHSAAPVGLIFTSAVFEGFAEDKATIKAAMDAVQNHRETVQPIREKTGGSTFKNPEGTSAWKEIDKAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLEHSGIRLQWEIKRIGNFRPGHAVQEFLGQLL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLF17_MOUSE
Sequence: MEQDNKEQAMHQPPMDNKMLVPVSNVPVSSGNSGFHQPPATQYLPEMMRSYMASAEELRCNEREWESQLIRSLPEHGVRCPSQLAPIPFQNYCQRSIGRGSHVMPVGSSGTLGVTISFSENLMPQGGLPSSRGVSVMAHSSAPAMPYPMPPTVPATTGSLKHGILLVPGMASAGTHAVAPFMDQMLHSINPCNPEMLPARFQQLLPLDSQDSLVTESNTQEEPFVREPPTPAPEGAESPSTSRGATRRQSPVSRPYVCTYNSCGKSYTKRSHLVSHQRKHTGVKPFACDWNGCTWKFFRSDELGRHKRIHTRYRPHKCDECDREFMRSDHLRQHKRTHLPK
What is the function of this protein?
Transcription repressor that binds to the promoter of target genes and prevents their expression.  Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer.  Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression.  May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
What are the official names of this protein?
Krueppel-like factor 17, Germ cell-specific zinc finger protein, Zinc finger protein 393.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLMU_CLAMS
Sequence: MTGELDVDGEPRSPSIAVVILAAGQGTRMRSRLPKVLHPLAGLPLVGHVLATAEELGARHVVTVVRHDRDQVVDVVSRLAPDALIVDQDEIPGTGRAVEVGITALPDGFTGQVVVLSGDVPLLDAATLRSLVSAHRQARNDLTLLTARLDDPTGNGRIIRGQDGAFEAIVEQKDATGEQLRIDEVNAGVYVFDAEALRQTLGAIGTDNAQREKYLTDAADVIRRAGGSIEALPVRDSWLVAGINDRVQLTAAATELNARIIRRWQLAGVTIHDPRTTWIDVKATLAADVTVLPGTQILGASTVAAGATVGPDTTLRDTEVGEDATVRRTDAELAVIGARATVGPFSFLRPGTRLGDEGKIGAYVETKNVEIGAGSKVPHLSYVGDATIGEHSNVGAGAVFANYDGVSKHRTEVGDHVHLGSRNVLVAPVRIGTGSYTGAGAVIRKDVPPGALGISVAPQRNMVGWTEAKRPGTPEARAAVEAADGPADDASDA
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH_ROSCS
Sequence: MGDETIKVAILGSGNIGTDLMYKLLDCPASMELVLLAGIDPNSEGLARARALGVAASAQGIDAVLEHPDIQIVFDATSAKAHVRHAKLLRETGRTAIDLTPAARGPYVVPPVNLRQHLDAPNVNLITCGGQATIPLVYAVSRVTPVRYAEIVSTVASRSAGPGTRQNIDEFTFTTAHGLEVIGGAQQGKAIIILNPAEPPILMRNTVYALPEDDFDPAQVRDSIEAMVAEVQQYVPGYRLKNPPVFDMRDTPWGRKSAVTVLLEVEGAGHFLPTYAGNLDIMTASARRVGDVFARHLLSRREVAV
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: RL28_STRP7
Sequence: MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKPKKVWASARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: HDHD2_HUMAN
Sequence: MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDFKGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL
What are the official names of this protein?
Haloacid dehalogenase-like hydrolase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: FSX1_HALSH
Sequence: MKRVGNCWKASVAAFFLLMFTAFAAADTTSVDTVSYKSNSEFFDGEVLQAGYVSNFATDKINVHLGASEIESKTGATAEEDLTLSVSHQNTYARYPLQETGLKKIYGWEGMKKTFDTKDQLWNWVTSNCADFTEGGVAIGDRTSKVEAAAKSWYDYWTGSYNYQAFCLRKNGYYGDVADIGSPDEIFRTEWRLQAGDKNPQTAIITNGDGGSGVVSNLGRYAKVKWQGNLDTGQNPPLVDDELAIHGNNYEGGWRVISEQRYDNYWNYIKNDGNRLLDKWKSGDYSESYIEGLLNGKAENAQKRYSESPLANAEVLDSSFQSGALKADMDSRLAYPEFNVYVDAGENGYITVSKPVGKPKIVSSSGASFGELSSGRISVDVKNVGGAEGSFSARAGSCSQYFQADALQNTKRVAPGETASYSFRVTFTSTSMQQASYTGRCSITVEDTGSGREVSTSVSVEATQQSECTQGKEIVKQKNGNDVIYSCPDGLKIQKQDTCTGELKAVFVNNDIQYDCREEGTGGGSGGGLFGKRFTLPITGTQLSNPLNAFENIWSGDANALNWLQVFVTFIAFLGGFALVGVKLGKIVDGLATEFIPVKDSHVRLVIGLLGGGMIATAVYQLVTDPLGLLVTVLGLVVMGYLYLSASAPEINL
What is the function of this protein?
Exhibits fusogenic activity (PubMed:35794124).  Mediates cell-cell fusion in mammalian cells (bilateral fusion) (PubMed:35794124).
What are the official names of this protein?
Fusexin 1, HnFsx1.
What is the protein family that this protein belongs to?
Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily.
Protein: AN_HCMVA
Sequence: MWGVSSLDYDDDEELTRLLAVWDDEPLSLFLMNTFLLHQEGFRNLPFTVLRLSYAYRIFAKMLRAHGTPVAEDFMTRVAALARDEGLRDILGQRHAAEASRAEIAEALERVAERCDDRHGGSDDYVWLSRLLDLAPNYRQVELFQLLEKESRGQSRNSVWHLLRMDTVSATKFYEAFVSGCLPGAAAADGSGGGGSHYTGSRAGVSPGIQFGIKHEGLVKTLVECYVMHGREPVRDGLGLLIDPTSGLLGASMDLCFGVLKQGSGRTLLVEPCARVYEIKCRYKYLRKKEDPFVQNVLRRHDAAAVASLLQSHPVPGVEFRGERETPSAREFLLSHDAALFRATLKRARPLKPPEPLREYLADLLYLNKAECSEVIVFDAKHLSDDNSDGDATITINASLGLAAGDAAGGGADHHLRGSPGDSPPPIPFEDENTPELLGRLNVYEVARFSLPAFVNPRHQYYFQMLIQQYVLSQYYIKKHPDPERIDFRDLPTVYLVSAIFREREESELGCELLAGGRVFHCDHIPLLLIVTPVVFDPQFTRHAVSTVLDRWSRDLSRKTNLPIWVPNSANEYVVSSVPRPVSP
What is the function of this protein?
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules.  Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate.  Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides.  Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
What are the official names of this protein?
Alkaline nuclease.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae alkaline nuclease family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RR12_TOBAC
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SMS_HUMAN
Sequence: MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
What is the function of this protein?
May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity).  This effect may be mediated by binding to GPR107 and PKA activation (By similarity).  May regulate cardiac contractile function (By similarity).  May compromise cardiomyocyte viability (By similarity).  In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity).  May also have anxiolytic and anorexigenic effects (By similarity).  May play a role in arterial pressure regulation (By similarity).  May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH.  Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476).
What are the official names of this protein?
Somatostatin, Growth hormone release-inhibiting factor.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: INVA3_ARATH
Sequence: MASTEALLPVTSLQDPLSESRSDQIPETRRRRPIKVHLAVYSGLLLIALYVTLIVTHDGSKAEIATESRPRMAGVSEKSNDGVWISSDDGKVEAFPWNNTILSWQRTAFHFQPEKNWMNDPNGPLFYKGWYHFFYQYNPNAAVWGDIVWGHAVSKDLIHWLYLPIAMVPDQWYDANGVWTGSATFLDDGSIVMLYTGSTDEFVQVQNLAYPEDPSDPLLLKWVKFSGNPVLVPPPGIGAKDFRDPTTAWKTSSGKWRITIGSKINRTGISLIYDTTDFKTYEKHETLLHQVPNTGMWECVDFYPVSKTQLNGLDTSVNGPDVKHVIKASMDDTRIDHYAIGTYDDSNATWVPDNPSIDVGISTGLRYDYGKYYASKTFYDQNKGRRILWGWIGESDSEAADVQKGWSSVQGIPRTVVLDTRTHKNLVQWPVEEIKSLRLSSKKFDMTIGPGTVVPVDVGSATQLDIEAEFEIKTDDLKLFFDDDSVEADNKFSCETNGGSTARGALGPFGFSVLADEGLSEQTPVYFYVTKGKHSKLNTVFCTDTSRSTLANDVVKPIYGSFVPVLKGEKLTMRILVDHSIVEGFAQGGRSCITSRVYPTKAIYGATKLFLFNNAIDATVTASFTVWQMNNAFIHPYSSDDLGVPSST
What is the function of this protein?
Possible role in the continued mobilization of sucrose to sink organs.
What are the official names of this protein?
Acid beta-fructofuranosidase 3, vacuolar, At beta fruct3, AtBETAFRUCT3, Acid invertase 3, AI 3, Acid sucrose hydrolase 3, Vacuolar invertase 3, Inv-V3, VAC-INV 3, VI 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein. Vacuole lumen. Note=May be released into the lumen of the vacuole from the tonoplast through a proteolytic processing.
Protein: CHAP1_MOUSE
Sequence: MEVCQELRKPALSLECGHCSFRGTDYENVQLHMGSIHPEFCDDMDAGGLGKLIFYQKSAKLFHCHKCFFTSKLYANVYYHITARHAASDKWSEQPKEQPSKDTESGKSPSPPERQNPAFDPAEARPTPALPMEAQKTSPSLCPESQASGPPVLEPQGAGPLISPEPQAPCLPAEASKAAPVPCPERVDPPCELPELEKPERGPSPESVKSALVSSKPPKHSSFADTGAAPSALSPESPVLATSPEPWGPSLSASPESRKPARTASPEPRKPSPAESPELWKPFPAIASEPRRPTPAVSPGSWKPGPPGSPRPWKSSPSATSGPWKSSKPVQPMSPGPWKPIPSVSPGPWKPAPSMSTASWKSSVSSGSWKTPPTSPESWKSGPPELRKTALPLSPEHWKAVPPVSPELRRPGPPLSPEIRSPAGSPELKKPSSSPDLWKVSPDQRKTSPASLDFPEPQKSSCGSPPDLWKSSFIMESQKPNVFSETRKHTASGSSESPKVASDIWKPVLSIDAEPRKSTLFPEPTKAVLPASPEPRKRALFPESRKHVFLPELPKSAVFSDAQKAPELSEEIQLEAVDNAKCDSLAQEGLLATPKKLLDEALSPSSKKLKKDSQENSDAELSSSEYIRADLDTLDTKGQESSSDQEQVDVESIDFSKENKMEMGSTEQAKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEVNKKLMEALESPLEEQQI
What is the function of this protein?
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis.  Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation.  May recruit CENPE and CENPF to the kinetochore (By similarity).
What are the official names of this protein?
Chromosome alignment-maintaining phosphoprotein 1, Zinc finger protein 828.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
Protein: ESTA_STRSC
Sequence: MSSAMRKTTNSPVVRRLTAAAVALGSCLALAGPAGSAGAAPADPVPTVFFGDSYTANFGIAPVTNQDSERGWCFQAKENYPAVATRSLADKGITLDVQADVSCGGALIHHFWEKQELPFGAGELPPQQDALKQDTQLTVGSLGGNTLGFNRILKQCSDELRKPSLLPGDPVDGDEPAAKCGEFFGTGDGKQWLDDQFERVGAELEELLDRIGYFAPDAKRVLVGYPRLVPEDTTKCLTAAPGQTQLPFADIPQDALPVLDQIQKRLNDAMKKAAADGGADFVDLYAGTGANTACDGADRGIGGLLEDSQLELLGTKIPWYAHPNDKGRDIQAKQVADKIEEILNR
What are the official names of this protein?
Esterase.
What are the subcellular locations of this protein?
Secreted.
Protein: PLAT4_HUMAN
Sequence: MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA
What is the function of this protein?
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625).  Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852).  For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464).  Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464).  Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852).  Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).
What are the official names of this protein?
Phospholipase A and acyltransferase 4, HRAS-like suppressor 4, HRSL4, RAR-responsive protein TIG3, Retinoic acid receptor responder protein 3, Retinoid-inducible gene 1 protein, Tazarotene-induced gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the H-rev107 family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: HISP_PSEAE
Sequence: MYSLQVEDIHKRYGSHEVLRGVSLRAGKGDVISIIGSSGSGKSTFLRCVNFLEKPCAGHIRVGDEELRTRPGALGELRAADPRQLQRIRSRLAMVFQHFNLWSHLTVLENVVECPVNVLRMNRDDAVARARHYLAKVGLAEKVERQYPCELSGGQQQRVAIARALAMEPQVMLFDEPTSALDPELVGEVLKVMQQLAEEGRTMVLVTHEMAFARQVSSHVIFLHQGVIEEEGTPDQVFGAPRSERLRQFLAGNLK
What is the function of this protein?
Part of the histidine permease ABC transporter.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Histidine transport ATP-binding protein HisP.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPPH_YERPS
Sequence: MIDDDGYRPNVGIVICNRQGEVLWARRYGQHSWQFPQGGINPGETPEQAMYRELFEEVGLNKKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQRWFLLQLMCNEAEINMQRSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFAATVMPVQEVAPPRVPPAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RUVB_BORPA
Sequence: MAIQSDSLSSLPDSPRIVAPQPVSPNEESIERALRPKALEEYVGQQRAREQLEIFIAAARKRGEALDHVLLFGPPGLGKTTLAHIIAHEMGVQLRQTSGPVLERPGDLAALLTNLERNDVLFIDEIHRLSPVVEEILYPALEDFQIDILIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVSRLEFYNTDELARIVTRSASLLNADITADGAHEVARRSRGTPRIANRLLRRVRDYAQVKAHGVIDQDAAGRALAMLDVDPQGLDVMDRKLLEAIVHKFDGGPVGVDSLAAAIGEERDTIEDVIEPYLIQHGYLQRTPRGRTATLTTWRHLGLNPPAAASGGTGELFSK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MED5_NEOFI
Sequence: MTAPVQWRTFFHQCLIHRIDASEFRNLSKLLFQKCPIAESALLDALLQTRSESRIKWDPLLPLYIDCLCRMGRVRTSTVLTSLLKYSSIHDKPQLPTSEGKDGSKCYTLMTDIRVIQDAMLSVSTGSTPKTNAEAIAIFFAIIDWIHAVASWHNSHFDPGQHSSGMMSSPDVVSLFESLGILLAALSGTGKGLEVLSADSHEGLKVKLGQALSAYLPLCVEVSLPLRNRLDGLQKEFNLYGERAPKSLDVPMMENMNVNALQFEASVMDGPVINSRAGLYVFINAMLVGRPLVDDSMLINYLANRYGGHYEALIEEILTAAFDVLSNGMYRNESSRTMFVFRSFLVNKLPAFFAAMLASTMVSIPMEMCISHALSRLDPNTFPSFSQMFEMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGYNKDELVSQINANPERAEQLINEIESMEGNAGAIIGAITEVMHNLCNQKETMTLKNICNSLSRRPQALDVVLIFRNPKQVLQPLCALLDSWHWDEDQGEYQPVYDEFGSILLLVLAFKYRFDLRPADLGISSNDSFVLRLLERGTCSQKLDALDEKQNKNLGSWIAALFIAEGISEETMSACSPQEFYLLVATLFSQSLEACETGKLEFDTLKGGFEYLLEPFLLPSLIFALTWLGDHIWETELDPSIPLKALQSLVNPSSISGEAREIHRTVLNITARTLEEQLKDVRTRHPSRTDIKPILDSLEPCLSFQLVGSSHRSELESWTTHSGGGLLGGIRSTFQSLVLWSTNPEVSMAPPPYTHRQLIAGVRMLGASRVLPPLIEELKLQTEAGNGPLALDLAATLICAPMAETFSVEQNSHQPVDPNKEALPRCGILTLRDVLALQHENVPKISEKDPLRAEVLVRLYRRVNALLAPPSQVPNLDVNNIIQNMQLGGVGVGVGAGQMELDAAGAADHGVGPDDAENIHRMIDNAAAAAALDSSGTGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 5, Mediator complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TEG6_HHV2H
Sequence: MTTTPLSNLFLRAPDITHVAPPYCLNATWQAENALHTTKTDPACLAARSYLVRASCSTSGPIHCFFFAVYKDSQHSLPLVTELRNFADLVNHPPVLRELEDKRGGRLRCTGPFSCGTIKDVSGASPAGEYTINGIVYHCHCRYPFSKTCWLGASAALQHLRSISSSGTAARAAEQRRHKIKIKIKV
What are the official names of this protein?
Tegument protein UL55.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL55 family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus matrix.
Protein: AA1R_RABIT
Sequence: MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPETYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKAVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLREVQRAWAANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRRQLSKKASASSGDPHKYYGKELKIAKSLALILFLFALSWLPLHILNCVTLFCPSCQKPSILVYTAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCRPAPAGDGDEDLPEEKPND
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXJ_IDILO
Sequence: MKGLRLGVNIDHVATLRNARGVRYPDPVAAAAIAEQAGADGITIHLREDRRHITDRDVAMLKQTLNVPMNLEMAVTEEMLDIAIKTQPTYSCLVPEKRQELTTEGGLNVAGQLETITDATRRLSDAGIQVSLFIDADHEQIDAAKKAGAPIVELHTGQYAEAETEEQRTVELARLMEASEYAHSIGLQVNVGHGLHYHNTLEVAEIPQVCELNIGHSIIARAVLVGLDQAVRDMRNILDKAR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPNE3_PONAB
Sequence: MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQVVSSKKLTRPLVMKNGRPAGKGSITISAEEIKDNRVVLFEMEARKPDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASRCSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNDDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAAAQQQTASQYFVLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGGLRSPSGEVAIRDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLPPKNPATKQQKQ
What is the function of this protein?
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.
What are the official names of this protein?
Copine-3, Copine III.
What is the protein family that this protein belongs to?
Belongs to the copine family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner. Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner. Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin- dependent manner.