PharMolix/UniProtQA huggingface dataset:
Protein: ZP3_FELCA
Sequence: MGLSYGLFICFLLWAGTGLCYPPTTTEDKTHPSLPSSPSVVVECRHAWLVVNVSKNLFGTGRLVRPADLTLGPENCEPLISGDSDDTVRFEVELHKCGNSVQVTEDALVYSTFLLHNPRPMGNLSILRTNRAEVPIECRYPRHSNVSSEAILPTWVPFRTTMLSEEKLAFSLRLMEEDWGSEKQSPTFQLGDLAHLQAEVHTGRHIPLRLFVDYCVATLTPDQNASPHHTIVDFHGCLVDGLSDASSAFKAPRPRPETLQFTVDTFHFANDPRNMIYITCHLKVTPASRVPDQLNKACSFIKSSNRWFPVEGPADICNCCNKGSCGLQGRSWRLSHLDRPWHKMASRNRRHVTEEADITVGPLIFLGKAADRGVEGSTSPHTSVMVGIGLATVLSLTLATIVLGLARRHHTASRPMICPVSASQ
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP3 is essential for sperm binding and zona matrix formation.
What are the official names of this protein?
Zona pellucida sperm-binding protein 3, Sperm receptor, Zona pellucida glycoprotein 3, Zp-3, Zona pellucida protein C.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPC subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 3]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: NDPA_SHEAM
Sequence: MTIKVEQAIIHEIAQTHEGQLSCRLRPQPLLNSQAVELMLEELHQSYTSKSGKGFGFFGTHGNDGEANPAFANCLKDYLDGGLGFVEFTGVASKLLQDELGKYDFSQGGFLLLACYSHMASDYLFVALLSAKSSMTVLDDMELTQVNHLDLNNIQLAARIDLTEWQADKESRKYISFIRGRAGRKVADFFLDFMGCVEGINPKAQNKSLMIAVEDFVAGSELTKDERQACRDKVFEYCSERFDAGAEVDIKDLADELADSGMDSFYDFATTGNYDLEEEFPVDKSTLRQLKKFSGTGGGVTISFDGHHLGERVIYDPISDTLLIKGVPANLKDQLHRRLKGE
What are the official names of this protein?
Nucleoid-associated protein Sama_1557.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YBAB_ECODH
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CNO10_DANRE
Sequence: MKHDIASSPGMSDLEKEVATNAFEAFKTGSYDESLKYLDNLQELNKEDYKITMNKTVTEFYKSGQTTSSTNKESAALKAEFTAMIEAAKSKMHQYKVRAYIQMKSLKACKREIKSVMNTSGNSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGPLKTGECVRCMFWNNLGCIHFAMGKHNLGLFYFKKALQENDHTCAQIGDGSNAQASKKFSGIPMCALLANKRYELLYNCGIQLLHIGRPLAAFECLMEAVQVYHSNPRLWLRLAECCITANKGSSEQETKGLPSKKGIVQAVVGQGYHRKIVLASQSTQNTIYSEAQSAAIPVASMEFAAICLRNALLLLPEHQQHDSKPDNGSKSYSQSGGTESGSETSDACSGKTQEGDKFIPAAPSSPLRKQEVENLRCSILACSAYVALALGDNLMALNHAEKLLHQAKLSGSLKFLGHLYAAEALISLDGISDAIAHLNPENVTDVSLGVSSSEQDQGSDKGDLEPVESSGKQTPLCYPSSVSSARATMLFNLGSAYCLRSEYEKARKCLHQAASMVNTKEIPPEAILLGVYLELQNGNTQLALQIIKRNQLLPSVKPGSSPDFRKKPLSFQSTQPVQPIQTPSSFTQVQRK
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
What are the official names of this protein?
CCR4-NOT transcription complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the CNOT10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LEUD_BRUME
Sequence: MDKFTKLTGVAAPLPIVNIDTDMIIPKDYLKTIKRTGLGKGLFAEMRFNEDGSENPDFVLNKPGYRKAQILVAGDNFGCGSSREHAPWALLDYGIRCVISTSFADIFYNNCFKNGILPIKVAQEDLDKLMDDASRGANATLTIDLETKQIHGPDGGTISFDLDDFKRHCLLNGLDDIGLTMEKAKSIDTFEAKNAEERPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: SYH_HALH5
Sequence: MAIQIPRGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGDTTDIVQKEMYTFEDRGGRSLTLRPEGTASVTRAYVSNKLYGQANQPTKLFYIGPMFRYERPQSGRMRQFVQFGVEALGSADPAIDAEVLALVMRFYEELGLKNLKLVINSLGDTDSRLAHREALVNHFKPRIHEFCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHDYLSTESKAYFEKVQSYLTALNIPFVVDATLVRGLDYYNHTAFEVMVDGEGFGAITTLCGGGRYNGLVEEIGGPETPGIGFALSIERAIMALEAQQAKPAHNQAIDCYVVTLGEAAKDKGVELVYQLRNAGISAEKDYLDRKMKGQLKAADRLHAKWTVILGEDELAVGKVNVKNMETGEQTDVALTDLVSHMKQQVEGGNES
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
Protein: RL16_AQUPY
Sequence: MEKAEKGNPKGKAFRGNKLAFGEYGIQALDRAWITQQQIEAVRVALVRS
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MUTL_STRSV
Sequence: MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKSIQVTDNGEGIDHEDVPLALRRHATSKIKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATEAGRHGTLLVAQGGEIEEHVPTSSPVGTKIKIEDLFFNTPARLKYMKSQQAELSHIVDVINRLSLAHPEVAFTLISDGREMTRTAGSGNLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLPELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALISQAIATSLKEQDLIPDALENLAKSTVKRASKPEQTSLPLKENRLYYDKKQNDFFLKPQVAEQQLSFEESAKPVHEATDEKAEPQSTSVKFAERKPVSYDQLDHPELDQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVKYEYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMELLEDAGIFLEEYGANQFILREHPIWFKEEEIEAGIYEMCDMLLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTSLRELGKY
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: Y5168_BACLD
Sequence: MIIVTTDTIANQNIVEVKGLVTSSIVQSRNIGKDILSGLKSVIGGELKNYTQMLEDSKKAVRERLVNQAEELGANAIVGLRFELSAGQGTSELIGYGTAVVIG
What are the official names of this protein?
UPF0145 protein BLi01945/BL05168.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: ODO1_MOUSE
Sequence: MFHLRTCAAKLRPLTASQTVKTFSQNKPAAIRTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDMSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLEEDVLFHIGKVASSVPVENFTIHGGLSRILKTRRELVTNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCSTPGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQDPHKVKRLLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDAFKKFS
What is the function of this protein?
2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC).  Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC.  Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST).  Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids.  Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate.  Mainly active in the mitochondrion.  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
What are the official names of this protein?
2-oxoglutarate dehydrogenase complex component E1, E1o, OGDC-E1, OGDH-E1, 2-oxoglutarate dehydrogenase, mitochondrial, Alpha-ketoglutarate dehydrogenase, Alpha-KGDH-E1, Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: EPCAM_MOUSE
Sequence: MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA
What is the function of this protein?
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection.  Plays a role in embryonic stem cells proliferation and differentiation.  Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).
What are the official names of this protein?
Epithelial cell adhesion molecule, Ep-CAM, Epithelial glycoprotein 314, EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1.
What is the protein family that this protein belongs to?
Belongs to the EPCAM family.
What are the subcellular locations of this protein?
Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction.
Protein: SFMB_STRLA
Sequence: MNEMAGKAYGLAVRLDLRGALERTALQSALSAVVERHEALRTGLRQIDGTLTQVVVPGVTVSLPVVDLGGRGPDPAQLDREVRRLARQEAQRGWNLAQPPLLRGLLARLADDHHVLLLCVHHAVCDGLSLQIVLRELLENYTGGGPAGADEPLQFADYVVWNNGGEEFPDPEWSARRQAAREHWSSTLAGAPQVLDLPTDRRRPPLQSYAGARVPVRLDTAFADRVRDWSAQRGVTPFTTLLAAYTVVLARNGGADDLLVGLPVANRSHADLAGTVGYLANTCPLRADLRADPTLGELVRDLYDRLTGVLEHADLPFGELVELLAPPRMPERNPVFQVMFGLQQDVRRGWDLPGLRVDVEDVDCGNARVDLSLFLFEEADGAIDGFLEYASALFDRATAERFADQLHTVLRQILRDARIPVSAVDLVGNGSATTIDSFLDGGPLEQPWPLVWPRIRELAARRPSAEAVRDDAEALDYASLVDRVDAAAARLTAAGAGPGDRVAVLAERGVRAVVAMLACWRAGGVYVPVDPAAPLPRRELILEQAAPAVLVCEDPDEQPPHHRSRAVAIGDLTAEADAGAGTPAEPAPRPHDPAYLMFTSGSTGRPKGVAVSHANLSSFLHALTGRLALGPADRLLALTTTAFDISLLELLGPLVTGGTVVVAPSSAQRGAADLAARLSSPGITTAQATPAVWRLALSAGWRPREGFTLLCGGEALPPDLADLLAATPAEAHNLYGPTETTIWSCAARIRPGEPVTIGRPIPGTRVLVADAALRPVPPGVCGELLVGGPGVALGYLDDPARTAARFVPDPYHPGERLYRTGDVVRLRSDGLIEFVGRVDEQVKVRGHRIELGEIESALRALPGVRDAAATVLDPRGNARIAGYLVADDGALDTAGRAARLRQDLSEALPASMVPSELYAVPAIPLNPNGKVDRRALPGTGRRLEGGSERVAPSTDAEHAVAALWCELLSLPEVGVREDFFGLGGHSLLAADLLQRLERDLGARVPVAEFFMEPTVARLAATVSQLSGAVHQTPTQDPDGRAEQTAEPSPEDRGADGDGWDFPTVRRSVTVPGSDPVPLEVSP
What is the function of this protein?
Involved in the biosynthesis of saframycin A (SFM-A), a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family (PubMed:17981978).  Specifically adenylates glycine and loads it onto its peptidyl carrier domain, via a thioester linkage to the phosphopanthetheine moiety (PubMed:17981978).
What are the official names of this protein?
Nonribosomal peptide synthase SfmB, Glycine--[glycyl-carrier protein] ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: NHAA2_NOCSJ
Sequence: MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESLWSAQAAVSVSRWDLSMDLGHWVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAALGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAVVGPTFATQLRIFLLTVTVIDDIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSGLHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERLQAALHPWTSYLVVPLFALANAGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVAGVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAFESDQRDRATVGILIAAVLATGLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARATGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGELEVEDLAGYAADLGLDVEAFLRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTGPHDAETLARALEESRT
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPG_ECOSM
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFEQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YWR4_CAEEL
Sequence: MNHGSFFKATRPGLDHWFYWSKKNRWQTILL
What are the official names of this protein?
Uncharacterized protein B0302.4.
Protein: ARGC_PSYWF
Sequence: MLQIAIVGGTGYTGVELIRLLSSHPKVNIKWLTSRSEAGKPVASTFPSLRGISELTYSDLGEDTLSALTQCDVVFFATPHGVAMQQAEALVAAGVKVIDLAADFRLQSLQDFEHWYKHKHACPDLLKQAAYGLPEINREAIKSASVIGNPGCYPTTAILGLKPVIEAQNLASDALIEPRIIIDAKSGVSGAGRQAKLSLNYAETTDNFSAYGVAGHRHLPEIEQGVHVLLQSKFTQNIRFVPHLVPMIRGMFSTIHLGLTEAGCQLDLQAIYEQAYKDEPFIDVLPAGEFPDTRSVRASNRLRIAVHQNNSNKEATILVVQDNLVKGAAGQAVQCMNVMFGFEESLGLNHVPVVP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_ECO24
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQGKLISVKTDVLDLTINTRGGDVEQALLPAYPKELNSTQPFQLLETSSQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTKTFVLKRGDYAVNVNYNVQNAGEKPLEISTFGQLKQSITLPPHLDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNISSKGGWVAMLQQYFATAWIPHNDGTNNFYTANLGNGIAAIGYKSQPVLVQPGQTGAMNSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: M2OM_NEUCR
Sequence: MSSVKQSAQAATSDVVDTAKNATAETVTAATDFLHTPAVRAALPFINGGLSGMVATTVIQPIDMIKVRIQLAGEGKAGGPKPTPLGVTRDIIASGKAMDLYTGLSAGLLRQAVYTTARIGCFDTFMSRLSARAKEKGQSVGFKERASAGLAAGGLAAMIGNPADLALIRMQSDGLKPVAERKNYKSVIDALGGIARNEGVAALWAGAAPTVVRAMALNFGQLAFFSEAKAQLKARTQWSSKVQTLSASAIAGFFASFFSLPFDFVKTRLQKQTRGPDGKLPYNGMVDCFAKVAKQEGVFRFYRGFGTYYVRIAPHAMVTLLVADYLGWLTK
What is the function of this protein?
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane.
What are the official names of this protein?
Putative mitochondrial 2-oxoglutarate/malate carrier protein, OGCP, Mitochondrial carrier 33.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ARGJ_POSPM
Sequence: MSARLPALWKRLSSTISPRPAPPKAHHHAPIREAAFPNGYVLTGLHCGIKKTGALDLAVILSTTPKPASAAACFTRNAFKAAPVVVSEEVLQRSASTARALVVNSGCANAVTGKQGMEDAWAMVRATDALLGHSAKESETLVMSTGVIGQTLPICKVLAGIESQSSDSQTKSLGSDFTAWERAAKAFMTTDTFPKLRARTFSIDGREYKMAGMDKGAGMIHPDMGPPRMAGQLHATLLGCIMTDAAVSPRSLQSALTYAVDRSFNSISVDGDMSTNDTIVVLANGSAASDPAAEIDEERDPRTYQIFRDELTTFAADLAQLVVRDGEGATKFVTVSVNGAATYEDAHRIASRISTSALVKTALYGQDANWGRILAATGSVPLSVPIDPTRVSVSFIPTDGSPALPLLVNGEPETVDEARAKEIISVEDLEIEVQLGIGSENAKYWTCDFSYEYVRINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: FENR_ACIAC
Sequence: MENARLIEADAVVIGAGPVGLFQVFQLGLQGIAAHVVDALPHVGGQCAELYADKPIYDIPGVPVCTGRELVALLNRQIAPFSPQLHLSQRVETLQPAPDGGFLFATDAGAALHARTVFIAAGVGAFVPRTLKIDGIERFHGTQVFHHEEPAPTRGRQVVVLGGEDTAVARAIACAEPGPEAAASVTLVHRRDAFQAAPQDLARLQALRDSGRIRVLAAQVTGIEAAAQAGTPEPGRLTGVRLLASDGTEQGLPLDTLLLCLGVSPRLGPVADWGLALERKQVKVDTATFSAGVPGLYAVGDINTYPGKRKLILCGFHEATLAAFAAAEHLAGSPVALQYTTTSTRLKERLGVAGAGTP
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: STR9_STRTC
Sequence: MAVDRKIRIAVVGGGPGGVIAALALSKSPNVEIDLYEAATAFGDIGLSLGMPWRPWRILRLLGLQGYLAALLPPDQIPKEDVTVPTIHYRKSDQAVGEDIFTCTSLSGYTRFRRSHFHAALLPHLPSNCKTYTSKRLVSYAEPSNASDPIVITFADGTTAECDVLVGADGIKSPTRASMYNYAADEAEKAGRSAEANDLRSKIRAKFSGVEVYRSVISAEQLRAAAPDHHAFRCPTQFLGKEKVRMPTYPIQSENSQFLNCALYICDYSREGEDYPEPWVTDVEAKDLRSSLPDWEPEAQAAVSCMGEVVSRWAICTLSPLPFFQRSRVVLLGDAAVRVTTPFSTFSSDHCQTLACYDELPRCRLRPGDDAYILSEILTHPAVTRDNVQKALEIYSEVRVPMSTHVLESSRRTGMDCALHDEVAAADLKSLGERMQQEMVWAWEWNPEDEKKKALDLVEERLV
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase str9, Strobilurin A biosynthesis cluster protein r9.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: PRDX_CHAMQ
Sequence: MSIRVGQKAPDFTATAVFDQEFGTIRLSDYLDKRYVVLFFYPLDFTFVCPTEITAFSDRFKEFKELSTEVLGVSVDSEFSHLAWTQIDRKSGGLGELEYPLVSDLKKEISSSYNVLTEDGVALRALFIIDKEGIIQHSTVNNLSFGRNVDEALRTLQAIQYSQENPDEVCPVNWKPGSKTMKPDPVGSKVYFEAI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
2-cysteine peroxiredoxin, chloroplastic, 2-Cys Prx, Thiol-specific antioxidant protein, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIMM_JANSC
Sequence: MTNPDHTCVGAISGSFGVRGEVRLKSFCAEPSDIGSYGPLSTEDGAQTYTITLTRPVKAGYAAMLSGVATKEDADALRGTRLYAPRSALPSLPDDEFYHADLVGLTVLDTGGEVIGTVASVANHGAGDILELSGPGLPSGLLIPFTLAVVPTVDIAAGRVIVDMPDGLIGGDKPDTSDTAPLGQDFD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.