PharMolix/UniProtQA huggingface dataset:
Protein: SYD9_CAEEL
Sequence: MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKSVLLSLKSTDAPVGMDRAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICELKAQQAATPRVEQALTYIDSRVGKLERSLETALNSIYTLVQLQTGMTSSVNRLREDSTKNFSDLKTRMEMSLSPIKPFQQRFSRERSSSSSVERSPSRERSRSPL
What is the function of this protein?
Plays a role in regulating synaptic function, probably by modulation of endocytosis (PubMed:16803962).  May be dispensable in muscle for normal locomotion (PubMed:16803962).  May be involved in post-transcriptional mRNA processing, in parallel with unc-75 (PubMed:16803962).
What are the official names of this protein?
Zinc finger protein syd-9, Synapse defective protein 9.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: Y2144_PHOPR
Sequence: MSDIALSISILALVAVLGLWIGNWRICGVGLGIGGVLFGGIFVGHFTDSWGVALDSHTLHFIQEFGLILFVYTIGIQVGPGFFASLRSSGLKLNAFAALVVLLGCIVAIGLYKIFDVPLPVILGIFSGAVTNTPSLGAGQQILTELGAQEGMLDLTGMGYAVAYPFGICGILLTMWILRLAFRVNVDKEAEEFEVQNGHKKQNLHTLNVAIRNPNLNGLQLKDVPALAEGDIVCSRLKRGEKLHVPRPDTRIETNDLLHLVGAKHALEKARLVIGEVVDASLSTRGTDLRVQRLVVTNEIVLGKKISHLDLKEKYDVVVSRLNRAGVELVPTSQTTLQFGDILNLVGRQEAIESVSGIVGNAHQKLQQVQMLPVFVGIGLGVLLGSIPFYLPGFPAAIKLGLAGGPLLVALILARIGSIGKLYWFMPPSANLALREIGIVLFLAVVGLKSGGGFVDTLVNGDGLSWMGYGIVITLVPLLTVGFLARIVGQLNYLTICGMLAGSMTDPPALAFANGLHPTSGASALSYATVYPLVMCLRILSPQILALLLWAV
What are the official names of this protein?
Putative transport protein PBPRA2144.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL34_BACAA
Sequence: MKRTYQPNKRKRSKVHGFRSRMSTANGRKVLAARRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PFD3_YEAST
Sequence: MDTLFNSTEKNARGIPQAPFIENVNEIIKDPSDFELCFNKFQERLSKYKFMQESKLATIKQLKTRIPDLENTLKICQSLRNHSDEGDESDEPILLHYQLNDTLYTKAQVDIPEDRADLKVGLWLGADVMLEYPIDEAIELLKKKLADSEQSLTVSTEDVEFLRENITTMEVNCARLYNWDVQRRQDLKQAQEGTKNLKI
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
What are the official names of this protein?
Prefoldin subunit 3, Genes involved in microtubule biogenesis protein 2, Gim complex subunit 2, GimC subunit 2.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
Protein: MEP4_ARTOT
Sequence: MHGLLLAGLLALPSNVLGHPAEPPNSVNVTHRHIDTSAYFLPQLSLYNKSEDVAEYGGDNITGSSYSGGDHSASNLSSEDYVTVATSLLKATLPYASFRLIDDHYIGDSGIGHVHFRQTVYGIDIDNTDFNVNVGRDGKVFSYGSSFYEGEIPKANPVAKRDFSDPVNALIGAINTLNIPVTAAVGEVKTTPIEGNSTYMFKGTTGALTDPTAQLVYLQKDGGLHLTWRVETDVGDNWLLTYVDAKKNDQVHGVVDYVASAEYQVYPWGVNDPTDGERAHLYFPWFKTGSRNWHIDGRGWHTTTRGNNAIAQDNPSGGWEYEDNHRPTNPLLIFRYPYTQSMTPPASYRDASITQLFYTGNVYHDLLYILGFNEKAGNFQVNNWGKGGKGNDFTILNTQDGSGVNNANFATPPDGQPGRMRMYVWDTSTPYRDGSFEAGIVIHEYTHGVSNRLTGGPANSRCLSSLESGGMGEGWSDFFATVVHLKERDTRNKNYTIGEWASGRQGGIRKYPYSTDLHTNPLMYVDADGLESVHAIGTIWCTILNEVLWNLIERHGMGNVNKIKPTFKDGVPTDGRNLAMKLVLDGMALQPCLPNFVQARDAIIDADMNLTKGANRCELWKAFAKRGLGVGAAYNPEKRVGSSRVPGGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 4, Fungalysin MEP4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL21_STACT
Sequence: MFAIIETGGKQIKVEEGQEIYVEKLDVNEGDAFTFDKVLFVGGDAVKVGAPTVEGATVSATVNKQGRGKKITVFTYRRRKDSKRKKGHRQPYTKLTIDKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: Y4107_RHOP5
Sequence: MATSAAVKDEPATQFAKDQLKAIIERIERLEEEKKTISDDIRDVYAEAKGNGYDVKALRTIVRMRKQDADERAEQETILETYLQALGML
What are the official names of this protein?
UPF0335 protein RPE_4107.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: MUG_SALCH
Sequence: MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLLDFRCGVTKLVDRPTVQATEVKLHGLRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRGIAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELDQALIMRGL
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_SULNB
Sequence: MDKVKIQEIAEEAGLSNGELIEKAKELGFNVKAANSAISMDDAGILVDFAISGTLPKGFKKPGEKPKLKVVKKKTVEKEPETIVEAPVIEKETAPEKTEVIPEETENTVEESTAAETVESEPETAVIEEIETPAETAKEETVEAAPVVKEVKQRKGISVVSKKAESEAEKGTEIEKPKRRTLSRTGIKIVRKAKPAPVRAATRISMGSGAPTPPSKKKVKKGPAEARETGKKIDIFNHDSMSGDIDSGFGEEEVVLLDFSDKNIYEDMMRQEQKRREEAKKREAANGGPAKGRQPFRPQQRRSLKRGGKRKKYTKEESSEVITSVEIPENVRVYEFAEKVNRSVGEVVKVLFALGMMVTKNDFLSKDEIEILAEEFGVEVSTMNPLDELDYVQAYDEVEDTHLEERPPVITIMGHVDHGKTSLLDKIRSAKVADKEAGGITQHVGAYQVEKNGKKITFVDTPGHEAFTEMRARGAQATDIVIIVVAADDGVMPQTKEAIAHTKAAGVPMIIAMNKMDKESANPDNIKSQLAEIDVMAADWGGEYEFVPVSAHTGLGIDDLLETILLQAEMMELKADPTRKAKAVVVESSVEKGFGPVANVIIKNGTLHVGDNVIVGTTYGRIKAIKLDDGSAVKEIGPSTPAAIVGLNEVPGAGEALVAMDTDKEVRELAEKRAEYDRAKQLSKSTKASLDDLSALIAEGQLKSLPVIIKADVQGSLEAIKGSLEKLRNEEVKVNIIHEGVGGVTESDVTLADASEHAVILGFNVRPTGSVKKKAKELGVEVRTYTIIYDLLDDVKALLGGMMSPVIKEEVTGQAEVRETFVVGKVGTIAGCKVSDGVITRNSKARLIRDGVVVYESKISSLKRFNEDAREVKNGYECGIMLENFNDIKEGDVIETFKDVEEQVTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGT_ACTP7
Sequence: MENENKPNVANFEAAVAVKDYEKACSELLLILSQLDSNFGGIQEIEFEYPVQLQDLEQEKIVYFCTRMATAITTLFSDPVLEISDLGVQRFLVYQRWLALIFASSPFVNADHILQTYNREPNRKNSLEIHLDSSKSSLIKFCILYLPESNVNLNLDVMWNISPELCASLCFALQSPRFIGTSTAFNKRATILQWFPRHLDQLKNLNNIPSAISHDVYMHCSYDTSVNKHDVKRALNHVIRRHIESEYGWKDRYVAHIGYRNNKPVMVVLLEHFHSAHSIYRTHSTSMIAAREHFYLIGLGSPSVDQAGQEVFDEFHLVAGDNMKQKLEFIRSVCESNGAAIFYMPSIGMDMTTIFASNTRLAPIQAIALGHPATTHSDFIEYVIVEDDYVGSEACFSETLLRLPKDALPYVPSALAPEKVDYLLRENPEVVNIGIASTTMKLNPYFLEALKAIRDRAKVKVHFHFALGQSNGITHPYVERFIKSYLGDSATAHPHSPYHQYLRILHNCDMMVNPFPFGNTNGIIDMVTLGLVGVCKTGAEVHEHIDEGLFKRLGLPEWLIANTVDEYVERAVRLAENHQERLELRRYIIENNGLNTLFTGDPRPMGQVFLEKLNAFLKEN
What is the function of this protein?
Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose.  Likely acts as a key component of a general protein glycosylation system.  Also accepts UDP-galactose as a substrate donor, albeit with low efficiency.  Cannot use UDP-GlcNAc or UDP-GalNAc as substrate donor.
What are the official names of this protein?
UDP-glucose:protein N-beta-glucosyltransferase, UDP-Glc:protein N-glucosyltransferase, HMW1C-like protein, N-glycosyltransferase, NGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 41 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_DEISP
Sequence: MAKGTFERTKPHVNVGTIGHVDHGKTTLTAAITFTAAASDPTIEKLAYDQIDKAPEEKARGITINTAHVEYNTPTRHYSHVDCPGHADYVKNMITGAAQMDGAILVVSSADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDEELLELVEMEVRELLSKYEFPGDDLPVIKGSALQALEALQANPKTARGEDKWVDRIWELLDAVDSYIPTPERATDKTFLMPVEDVFTITGRGTVATGRVERGVVKVQDEVEIIGLRDTKKTTVTGIEMHRKLLDSGMAGDNVGVLLRGVARDDVERGQVLAKPGSIKPHTKFEASVYVLSKDEGGRHSAFFGGYRPQFYFRTTDVTGVVELPEGVEMVMPGDNITFVVELIKPIAMEEGLRFAIREGGRTVGAGVVAKVLE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGG_PSEAE
Sequence: MIFRSVSNTDFRARVRTLLLAGSTALAFVAAPVWAFSIDDVASKAKDLAGDKYSAPTSNLPSEFSEMKFADYQQIRFINERAYWGKLKTPFKLSFYHQGMHFDTPVKINEVTATTVKPIKYDRTKFDFGSLKFDENATKDLGYAGFRVLYPINKADKQDEIATFLGASYFRVVGKGQVYGLSARGLAIDTALPSGEEFPRFREFWIERPKAQDKQLVIYALLDSPRATGAYRFVLRPGKDAVMDVQARVFLRDKVSKLGLAPLTSMYLFGSNQPSEQHNFRPELHDSSGLQIHAGNGEWLWRPLNNPKHLSVSTFSVENPKGFGLLQRGREFSRYEDLDDRYDLRPSAWIEPKGDWGKGTVELVEIPTPDETNDNIVAFWNPETQPEVGKPLDFAYRLHWTMDEDELHDPKSSWVKQTMRSVGDVKQKNLIRQQDGSTALVVDFEGPALKDLAPDAPVTTQVSTDSNAEVVENSLRYNPVLKGWRLTLRIKVKDPKKPVEMRAALVDEAQKPLSETWSYQLPADE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MNMA_ACHLI
Sequence: MKKKVLIGLSGGVDSSVAALILLQQGYDVEAVFMRNWDSATNMDFRGNPTLYDETCEQEKDYQDALKVANKLGIKLHRVDFIHEYWDRVFSYFIDEYEKNRTPNPDVLCNNEIKFKAFIDYSEKFKPDYIAMGHYAQIDHTGDEPKLIRAVDSNKDQTYFLSQLKTEQLRNVLFPIGNLPKSEVRRIAKEHDLATADKKDSTGICFIGERHFNEFLLNYLPAKEGDMRRLDGTFIKRHFGLMNYTIGQRKGLGIGGTTDTTDAWFVVGKDLSTNTLYVEPGFEHPYLYSDEALITEVKWRGAKRDGKFTAKFRYRQEDQDVEIKWIDDETFKVFYPQKIRAVTPGQVCAIYEDEVCVGSGFISVVYNEGEKRLYS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOPI_DROME
Sequence: MKVKVSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENARVVVVKNNPTKPIFSDTYL
What is the function of this protein?
Required for male meiotic division and spermatid differentiation.  Required for accumulation of aly and comr on chromatin.  May function as a transcription factor.
What are the official names of this protein?
Testis-specific zinc finger protein topi, Protein matotopetli.
Protein: HA22C_ARATH
Sequence: MPSNSGDDNVLQVLIKNFDVLALPLVTLVYPLYASVKAIETRSLPEDEQWLTYWVLYALISLFELTFSKPLEWFPIWPYMKLFGICWLVLPQFNGAEHIYKHFIRPFYRDPQRATTKIWYVPHKKFNFFPKRDDDDILTAAEKYMEQHGTEAFERMIVKKDSYERGRSSRGINNHMIFDDDYRY
What are the official names of this protein?
HVA22-like protein c, AtHVA22c.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PME_ASPAC
Sequence: MVKSVLASALFAVSALAASRTTAPSGAIVVAKSGGDYTTIGDAIDALSTSTTDTQTIFIEEGTYDEQVYLPAMTGKVIIYGQTENTDSYADNLVTITHAISYEDAGESDDLTATFRNKAVGSQVYNLNIANTCGQACHQALALSAWADQQGYYGCNFTGYQDTLLAQTGNQLYINSYIEGAVDFIFGQHARAWFQNVDIRVVEGPTSASITANGRSSETDTSYYVINKSTVAAKEGDDVAEGTYYLGRPWSEYARVVFQQTSMTNVINSLGWTEWSTSTPNTEYVTFGEYANTGAGSEGTRASFAEKLDAKLTITDILGSDYTSWVDTSYF
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.
What are the official names of this protein?
Pectinesterase, PE, Pectin methylesterase.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted.
Protein: CSRA_CLOBL
Sequence: MLVITRKKGESLLIGDDIEITVVKLDDGSVKLAIDAPKKLTILRKELYNEVQEENKKATNFNPSILKNIKSK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P_ESCF3
Sequence: MTIKVGINGFGRIGRIVFRAAQKRSDIEIVAINDLLDADYMAYMLKYDSTHGRFDGTVEVKDGHLIVNGKKIRVTAERDPANLKWDEVGVDVVAEATGIFLTDETARKHITAGAKKVVLTGPSKDNTPMFVKGANFDKYAGQDIVSNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTPNVSVVDLTVRLEKPATYEQIKAAVKAAAEGEMKGVLGYTEDDVVSTDFNGEVCTSVFDAKAGIALNDNFVKLVSWYDNETGYSNKVLDLIAHISK
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VALB_STRHJ
Sequence: MDGVRAVLLAGGEGRRMGPLGRGRLKPLVPFGGTSRLIDFSIANVHRSGLRDVLLLSQYEERRLMDDLHLVWNGRHRGFRIDFGPYDAVYRRSPGKLPEQLPERTWPLERGTADALLTKAEYVFRQGDAEASEILVLHADHVYRFDYGDMIREHRASKAALTVSYQRIERRYVHLFGMVEFDGDGLLTAFEEKPDDPTSDLVFAAFCLFDAATLRRYLEQLRGTDWQHDISRDVIPAMLAGGELIRGYEVKSYWEDIGTVDRYHRAHRGLLRADPTLALSDMPLTVAPEVPRHLVPGGPGRRASVVAADVANEGEIVSSVVYPGARIGVDAHVVDCVVLPGAQVPDGTHLASAIVLEDGSVQQCEAEREEVAL
What is the function of this protein?
Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16632251, PubMed:20981366).  Catalyzes the conversion of valienol 1-phosphate to GDP-valienol.  Also able to use efficiently ATP as nucleotidyl donor, but other NDP derivatives are less efficient (PubMed:20981366).
What are the official names of this protein?
Valienol-1-phosphate guanylyltransferase, Cyclitol nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: PTH_ACIET
Sequence: MIKLFVGLGNPGPEYEATRHNAGFWWIDALARELKVTLVPERSYHGLVARASVAGHSVWLLQPQTFMNLSGKSVAALARFFKIPPEEILVAHDELDIPPGQAKLKRGGSHAGHNGLRDIHAQLGTSDYWRLRIGIGHPGVKAEVVNWVLKKPAPDQRTLIEDSILHSLKAYPALLAGDMDKATLLVHTTKPPRPKATRPAQAQAAPQAGAD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_FRAAA
Sequence: MASWPELIGALLARESLDSARTAWAMDQIMAGAATPAQIAGFAVALRAKGETPAEIGGLIAAMRAHAAPLRIPDEIRARAVDTCGTGGDRSNTVNLSTMAALVVAGAGVPVIKHGNRAASSACGSADLLAELGVAIDLPPAGVEACLRAAGIAFCFARIFHPAMRHVGGPRAEIGVPTAFNILGPLTNPAEPGAQAVGVADARLAPVVAQVLADRGTRALVFRGDDGLDELTPTTTSTIWVIPGGQPSAAGEAAGQTAAPPRREQFDPRDVGIHVPDIAVLRGADAPHNAAVTRALLAGEPGPVRDTVLLAAAASLVAAAGPTDAAITEQIAAALPRAAHAIDSGAAAAVLDRWTDASQAAAAAAAIAR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PRS6A_SCHPO
Sequence: MSTLEELDALDQSQQGGSSNNEGLDGIEQEILAAGIDELNSRTRLLENDIKVMKSEFQRLTHEKSTMLEKIKENQEKISNNKMLPYLVGNVVEILDMQPDEVDVQESANQNSEATRVGKSAVIKTSTRQTIFLPLIGLVEPEELHPGDLIGVNKDSYLIIDKLPSEYDSRVKAMEVDEKPTERYSDIGGLSKQIEELFEAIVLPMQQADKFRKLGVKPPKGCLMFGPPGTGKTLLARACAAQSNATFLKLAAPQLVQMFIGDGAKLVRDAFALAKEKSPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFSSDDRVKVIAATNRVDTLDPALLRSGRLDRKLEFPLPNEEARVGILRIHSRKMAIDDDINWEELARSTDEYNGAMLKSVCVEAGMIALRQGDTKINHEHFMDGILEVQMRKSKTLQYFA
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit 6A.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CCNQ_MOUSE
Sequence: MEAVRPDSCESGPAAPRAEERPAPEARVHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGSEPLELDSRFWELRDSIVQCELLMLRVLRFQVSFQHPHKYLLHYLISLKNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGEAEKPWWQVFSDDLTKPIIDNIVSDLIQIYTMDTEIP
What is the function of this protein?
Activating cyclin for the cyclin-associated kinase CDK10.
What are the official names of this protein?
Cyclin-Q, CDK10-activating cyclin, Cyclin-M, Cyclin-related protein FAM58A, Cyclin-related protein FAM58B.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin-like FAM58 subfamily.
Protein: ACTPA_ACTTE
Sequence: NAAVAGAVIEGATLTFEVLQ
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.
What are the official names of this protein?
Cytolysin tenebrosin-A, DELTA-actitoxin.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: HRCA_BRUC2
Sequence: MMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSRLLPHTLSPATIRNVMSDLEHLGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSSIEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKTDVALKHIEFVRLEPMRALAVLVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQLSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQLLDLAEAGSGVRIFIGSENKLFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVPMVDYTAQIVSRLLR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ISDC_STAAR
Sequence: MKNILKVFNTMILALIIIIATFSNTANAADSGTLNYEVYKYNTNDTSIANDYFNKPAKYIKKNGKLYVQITVNHSHWITGMSIEGHKERIISKNTAKDERTSEFEVSKLNGKIDGKIDVYIDEKVNGKPFKYDHHYNITYKFNGPSDVAGANAPGKDDKNSASGSDKGSDGATTGQSESNSSNKDKVENPQTNAGTPAYIYAIPVASLALLIAITLFVRKKSKGNVE
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds hemoglobin and almost exclusively free-base protoporphyrin IX.  Probably has a role as the central conduit of the isd heme uptake system, i. e.  mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF.  Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor.  The reaction is reversible (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein C, Staphylococcal iron-regulated protein D.
What is the protein family that this protein belongs to?
Belongs to the IsdC family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan- anchor. Note=Anchored to the cell wall by sortase B (By similarity).
Protein: SMSR1_DROME
Sequence: MCDGEIGDPVTQPRSEGGGLVTMDQETRTHYLDAATDKHLTNGSPDPEPVDPLLVAQWSIENVTSWATCMEHFSRTLLDCLRQEAIDGEVLLSLTEEDVRDMRYKLGYKLTFGELKKFWIAVLKLQLLVKNSSAESVILGIECHGNGNSVYMPLASTGCGPPSSSTCPCPQAECPSYVSDCDTYLRMGGRYVPPEYFKTAMSLGYSFVVTWITSLTMVIVHERVPDMKRYPPLPDIFLDNVPHIPWAFNMCEITGSLLFTIWVVVLTFHKYRLVLLRRFFALAGTVFLLRCVTMLITSLSVPGTHLQCSQKDFAIDDPNVDMVGALIIRMSRAYRIWSGLGMSIQGVRTCGDYMFSGHTVALTLLNFFITEYTPRNLYFLHTLTWLLNMFGIFFILAAHEHYSIDVFVAFYITSRLFLYYHTLANNRALMQSDSKRTRVWFPMFSYFESSVDGMVPNEYDTLGSLIDGIIEQIFKAKDQLAISVKRCWLDAPLSGNSSAHMFGGESEQCLRNGTASAAFFSPHQSLIGGLGGQRSQTHLNSAQSGSSTPTPATSAPTKSLPTQKKTFRDASVDPFSRTTFAAVQQAENVKDSPMKEKKHL
What is the function of this protein?
A phosphatidylethanolamine (PE)/ceramide ethanolamine phosphotransferase that catalyzes the synthesis of ceramide phosphoethanolamines (CPE), a class of lipids that is a sphingomyelin analog and a major membrane constituent in Drosophila.  Transfers the head group from PE (1,2-diacyl-sn-glycero-3-phosphoethanolamine) on to different ceramides such as N-acylsphinganine (dihydroceramide) and N-acyl-(4R)-hydroxysphinganine (phytoceramide) to form N-acyl-sphinganine-1-phosphoethanolamine and N-acyl-(4R)-hydroxysphinganine-1-phosphoethanolamine, respectively.  Operates as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum, which is critical for the integrity of the early secretory pathway.
What are the official names of this protein?
Ceramide phosphoethanolamine synthase, CPE synthase, Sphingomyelin synthase-related 1, SMSr.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.