Protein: LIN12_CAEEL
Sequence: MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF
What is the function of this protein?
Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions (PubMed:3419531, PubMed:3000611).  Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11 (PubMed:18036582, PubMed:18700817, PubMed:32053105, PubMed:3419531).  Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes (PubMed:8343960, PubMed:7566091, PubMed:16197940, PubMed:10830967, PubMed:16530045, PubMed:18381292).  Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells (PubMed:3419531, PubMed:18036582).  Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10 (PubMed:9389650).  Best known for involvement in cell-fate decisions during development, but also plays roles in other events (PubMed:10903169, PubMed:18599512, PubMed:21549604, PubMed:27661254).  Regulates recovery from the dauer larval state (PubMed:18599512).  Modulates chemosensory avoidance of octanol and quiescence during molting (PubMed:21549604).  Promotes basement membrane mobility during tissue remodeling (PubMed:27661254).  Involved in establishing left-right asymmetry during intestinal organogenesis (PubMed:10903169).
What are the official names of this protein?
Protein lin-12, Abnormal cell lineage protein 12, Notch-like protein lin-12.
What is the protein family that this protein belongs to?
Belongs to the NOTCH family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Note=Localizes to the apical cell membrane of vulval precursor cells. SUBCELLULAR LOCATION: [lin-12/Notch intracellular domain]: Nucleus. Note=Becomes localized to the nucleus during signal transduction.