PharMolix/UniProtQA huggingface dataset:
Protein: NORR_ECOHS
Sequence: MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMLPGDATPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYRFPGNVRELEHAIHRAVVLARATRNGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAACARMLETDVANLHRLAKRLGMKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: YFEO_SALNS
Sequence: MFHPRARTMLLLSLPALIIGVASSLVLIAAMKVASVFQQFLWQRLPTSIGIAYDSPFWIVGMLTLTGIVVGLIIRYSPGHAGPDPAIEPLISMPVSPSALPGLLLALIIGLAGGVSLGPEHPIMTINIALAAAFGSRLFPRITALDWTILASAGTIGALFGTPVAAALIFSQTLSGSNDIPMWDRLFAPLMAAAAGSLTTSLFFHPHFSLPIAHYTQMRLVDIASGAIVAAIAIAAGMVAVWCLPRLHELLHRLKNPVLILGIGGFILGILGVIGGPLTLFKGLDEMQQMAFSQTLGAGDYFTLAVVKLAALVIAAASGFRGGRIFPAVFIGAALGLMLHAHVEAVPAAITVSCAILGLVLVVTRDGWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPLLAANRHEP
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS16_CARHZ
Sequence: MAVKIRLKRMGAKNNPFYRVVVADARSPRDGRVIDEIGYYDPVKQPAAVVINEEKALDWLKKGAQLTETARALFRKAGVLQKFQQK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: VNPA_HOPST
Sequence: SGSKTAKIGDGCFGVRLDRIGSTSGMGCGGVPKPTPGGS
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Natriuretic peptide HsNP-a.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: NTP1_MCV1
Sequence: MNLHAAYIDYALRRSQHMQAEMSGADNVLLKDYQLFVAKVFLGLDSMNSLLLFQETGVGKTVTAVYMLKHLRFLYTSWTVLVLVKKALVEEPWMNTILRFAPEVAKDCVFMNYDDQNFHNKFFTNIKTVSARSRIFVIIDECHNFISKSLSREDGRARNTKHVYNFLARHIASSHNKLLCLSATPIVNNVREFALLVNLLRPGVLPPQSLFHNKRLLDEAELVSKLGCICSYLVHHEASIFEDVEGSELFARKRVLLKYVRMSAKQEDIYHKARAAEFRSGIAVFRVHRRMAATFAFDEFPVRKNLTPDEYDALVASLVRDFEALFAGRALSDATRARLRAGEPIECAASAEDLSLYQALYEHSCKYAEVCVAILASPGKCLVFEPFINLSGIRIFVKYLEVFGISYIEFSSRTKDTRTRAVAEFNRVENTNGELIKTCVFSLSGNEGISFLSINDIFILDMTWNEASLKQIIGRAIRLHSHANNPPERRYVNVHFVVAQLGSGAPSVDDDLLEIIQNKAREFSQLYRVLKLASIEWIHQHCREFAPVDDEAGFRALCSRAIDVTRGASTRRALATGENIWYAFSTLMITVHPGFKTEDGRVYDADGNFLTTMPERPIVRVQGTRLVYIFPELR
What is the function of this protein?
DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts.  Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex.  NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity).
What are the official names of this protein?
Nucleoside triphosphatase I, NPH-I, Nucleoside triphosphate phosphohydrolase I, NPH I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. NPH I subfamily.
What are the subcellular locations of this protein?
Virion. Note=Virion core enzyme.
Protein: RS4_SHEHH
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDSKCKLETAPGQHGARKTRLSEYGVQLREKQKVRRIYGVLEKQFRNYYKDAARTKGNTGENLLTLLETRLDNVVYRMGFGATRAESRQLVSHKSIMVNGSVVNIPSFKVSANDVVSVREKSRTQARIKAALEVSAQREKPTWVEVDNTKMEGAFKRIPERSDLSAEINEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: DYR8_ECOLX
Sequence: MIELHAILAATANGCIGKDNALPWPPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGRTCIVMTRQALELPGVRDANGAIFVNNVSDAMRFAQEESVGDVAYVIGGAEIFKRLALMITQIELTFVKRLYEGDTYVDLAEMVKDYEQNGMEEHDLHTYFTYRKKELTE
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase type 8, DHFR type IIIC, Dihydrofolate reductase type VIII.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: TRHO_NOSP7
Sequence: MNSENTQIVAALYKFVKLPDFAQKRDPLLSYCQAQGVKGTILLAQEGINGTIAGSRQAIDSVLWFLRSDPRLADLEYKESYTETPPFERMKVRLKSEIVTLGLPEIDPTEKVGTYVSPQEWNDLICDPEVTVIDTRNDYEVNIGTFQGAENPQTGSFREFPDYVVHNLDPTKHKKVALFCTGGIRCEKASSFMLAQGFAEVYHLKGGILKYLEEVPAQESLWQGECFVFDERVAVSHGLEEGSYELCFCCGYPISEEDKISPKYEQGISCAYCFDSLTEEKRARQQEKWRHYQTQVANSKNRDVS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: URE2_RHILW
Sequence: MIPGEIIAASGDIELNAGAPTVTLEVSNTGDRPVQVGSHYHFAETNAGLSFDRAAAHGKRLDIPAGTAVRFEPGQTRSVTLIPLSGKREVYGFRQLVMGKL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_SALSV
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPLEALVRQKVPTKPVTCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHFDGILGINIGKNKDTPVENGKDDYLICMEKVYAYAGYIAINISSPNTPGLRTLQYGDALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAPDLCEEELIQVADSLLRHNIDGVIATNTTLDRSLVQGMKNCQQTGGLSGRPLQLKSTEIIRRLSQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PGSA_SALPA
Sequence: MQFNIPTLLTLFRVILIPFFVVVFYLPFAWAPMVSALIFCIAAITDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARGDLLDQ
What is the function of this protein?
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: O16A_CONTE
Sequence: MKLTCMMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNKRWCKQSGEMCNLLDQNCCDGYCIVLVCT
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.  Binding of this toxin is strongly calcium-dependent but not voltage-dependent.  The binding site is most likely on the extracellular side of the sodium channel.  Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it.  Has also no effect on Gambusia fish.  Is important in mollusk for the paralysis of the prey.  Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!).
What are the official names of this protein?
Delta-conotoxin TxVIA, Conotoxin King-Kong 0, KK-0, TxIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VPR_HV196
Sequence: MEQAPEDQGPQREPNNEWTLEILEELKREAVRHFPRPWLHNLGQHIYTTYGDTWEGLEAIIRILQQLLFIHFRIGCHHSRIGIIPQRRGRNGSSRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: NIR_ARATH
Sequence: MTSFSLTFTSPLLPSSSTKPKRSVLVAAAQTTAPAESTASVDADRLEPRVELKDGFFILKEKFRKGINPQEKVKIEREPMKLFMENGIEELAKKSMEELDSEKSSKDDIDVRLKWLGLFHRRKHQYGKFMMRLKLPNGVTTSAQTRYLASVIRKYGEDGCADVTTRQNWQIRGVVLPDVPEILKGLASVGLTSLQSGMDNVRNPVGNPIAGIDPEEIVDTRPYTNLLSQFITANSQGNPDFTNLPRKWNVCVVGTHDLYEHPHINDLAYMPANKDGRFGFNLLVGGFFSPKRCEEAIPLDAWVPADDVLPLCKAVLEAYRDLGTRGNRQKTRMMWLIDELGVEGFRTEVEKRMPNGKLERGSSEDLVNKQWERRDYFGVNPQKQEGLSFVGLHVPVGRLQADDMDELARLADTYGSGELRLTVEQNIIIPNVETSKTEALLQEPFLKNRFSPEPSILMKGLVACTGSQFCGQAIIETKLRALKVTEEVERLVSVPRPIRMHWTGCPNTCGQVQVADIGFMGCLTRGEEGKPVEGADVYVGGRIGSDSHIGEIYKKGVRVTELVPLVAEILIKEFGAVPREREENED
What is the function of this protein?
Catalyzes the six-electron reduction of nitrite to ammonium.
What are the official names of this protein?
Ferredoxin--nitrite reductase, chloroplastic, NiR.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYS_AZOC5
Sequence: MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAASKEIGQAKAAKDEARAAALMDEVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPEGKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFETASKLSGARFVVNKGPLARLERALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDETDAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQFTKVEMVSITTPETSEEEHHRMLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWLPGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQQEDGSIVVPDVLQSYMGGVTVIAKA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_ROSCS
Sequence: MAKKTIRDIDWSGKRALVRVDFNVPLENGQITDDTRIRAALPTIRYLLEHGAAVILMSHLGRPKNKVVESMRLAPVVARLAELLPEAKAVKGSQATTGPAAEAAARDLKPGEVLVLENTRFDPREEANDESMARELAKLGDVYVNDAFGSAHRAHASTEGVARFLPAVAGFLMEAELAALQGALENPARPFVTIIGGAKISDKIGVIENLLGKVDALLIGGGMANTFLLAQGHEMGDSLVEPDSAPIAKSLLDQAAQRGVRLMLPTDVVIADAFSADANRKVVPVGEIPPGWRALDIGPETIRAYTEVITGAQTVIWNGPMGVFELAPFAEGTRAIAQAMANCPGMTIIGGGDSVAAIEQMGLADKIRHISTGGGASLELLEGRILPGVAALNDA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_MYCTU
Sequence: MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACPDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHFRELTIGQVKAALAAEGITVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD8_HUMAN
Sequence: MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAASRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit S14, p31.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S14 family.
Protein: IF1C_SACOF
Sequence: MTEKKNRREKKNPREAKVTFEGLVTEALPNGMFRVRLENDTIILGYISGKIRSSSIRILMGDRVKIEVSRYDSSKGRIIYRLPHKDSKRTEDSKDTEDLKDTKDSKD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RECR_CLOD6
Sequence: MQVYTGPITRLIEEFSKLPGVGRKTAQRLAFHIINMNTNDVEALSKAIIDAKREIRYCSICCNITDTDPCSMCSNKSRDSSVICVVEDPRDVAAMERTREFKGQYHVLNGVISPMDGIGPDMLKIKELIQRLGNQEVKEIIMATNPTIEGEATAMYIARLVKPMGIKVTRIAHGLPVGGDLEYADEVTISKALEGRREI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SLX1_ASPOR
Sequence: MANVDDVHTKPIPAFYCCYLLRSTVRQTSLYIGSTPHPSRRLAQHNGVSRGGARKTANDKRPWEMVLIVEGFMSRTAALQFDTIYTTWAWQKPGKSRHLGDDDNTESAREKGKTRPRGPARSLKGHLENLHALLRSTYFSGLPLRVRFFADDVHQLWRVWSDRIDGFIPEHIKVIPDGSCFENRQPGIEYLRVGSVEHIQVDYSKIHSYLEKTTFQLDDPEDLQCKVCQAPVVPKEELVLVCPQTRCYCVSHLLCLSARFLDSTKDRGRLIPISGKCPGCHKTIQWSLMMQELSFRTRGAKELQAILRKKKRGDCRVKDVPEKDTDDVGTVTAECCDFPESVGGSIEGPGDASDESTHDDVRLDDDWYESLGIESDHEIADWSESHPAMPTRVEIVIEDSDCDNTG
What is the function of this protein?
Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit slx1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_ECO27
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QCR7_DEBHA
Sequence: MASITSIVKTADYILSRPVLSKVVSPVAKAFVAYAGYREMGLKFNDLLIEETPVMQKAISRLPDEEIYARNYRFITAHQCSLSHQLLPANQAVKPEEDTHYLVPYILEAEKEAFERAELDNIEVPN
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 7, Complex III subunit 7, Complex III subunit VII, Ubiquinol-cytochrome c reductase complex 14 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCRB/QCR7 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RIMO_CLOB8
Sequence: MSEIKIEIAKNREQYNEEASSKYKVGMVSLGCDKNRVDSEIILGKMSDEYEITNNPKNADIIIVNTCGFIESAKQESIDTILEMANYKINYKCKLLIATGCLTQRYGEELKTLIPEIDIMLGVNDYNKINEIITEFIDGNKLATELLNYSDENINEGKRIITTQRESAYIRIAEGCNNFCTYCIIPKIRGKFRSRKMENIINEARDLSESGVKEIILIAQDTTLYGSDIYGKKNLHVLLKELSKIEGIEWIRVLYCYPEEIYDELINEIACNEKVVKYLDIPIQHISDKILKLMGRKTSKKDIINKIQILRERVPEIVIRTTFIVGFPNETDEDFNEIIDFLKEYKLEKVGAFTYSQEEDTPAAKMDGQIDEEIKEKREEDLMLLQKNISEEINKLKIGKLYDILVEGYNGKCYYGRSYEMAPDIDANVLFESNAKIENGEFVKVKIVETMDYDLVGVVVDESCK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_ANADF
Sequence: MLSQEVLKKLEAIEQRFEELTALLSDPSVASNGDRFRKVSKERASLEPTVEALRAYRKLVTDIGDNEALLEEKDPDLREMAKEELAQLRPQVDPAEEQLKLYLVPKDPADEKDVILEIRAGAGGDEAGLFAAELLRMYLRYAERRGWRTEVADTSAGNLGGVKDVTVNIAGDSVYSWLKFESGVHRVQRVPATEAQGRIHTSTVTVAVMPEAEDIDIQVSPADIEMDVFRSTGSGGQSVNTTDSAVRLTHKPTGIIVKCQQEKSQLKNRNMAMRMLRAKLYEIELERQRSARDAARKSQVGTGDRSEKIRTYNFPQDRLTDHRINYTRHNLPAVMDGDVQDVIDACRTFYAAQALREASRGNAADGAAERRA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BL1S6_DROME
Sequence: MLKSSNINSVLNELPNDPARDSTAQSSHNGKPKQDAETCCSSQDNEVMASLAALQLSAGVLQIAEPPLNHVRTQLRELIGRQNKTYIDLSKEKYKLDCSEVARLNDMMSDVKRYKDKLTKIKKEMQGVYQRTKELKKRAANVAACKQRDYQRKLERLQHEESLIGSQ
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021).  In response to high synaptic activity at neuromuscular junctions, plays a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021).
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 6, BLOC-1 subunit 6, Pallid protein homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S6 family.
What are the subcellular locations of this protein?
Synapse. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=At the neuromuscular junctions, present at both pre- and postsynaptic compartments where it associates with cytoskeletal neuronal microtubule structures and muscle Z-lines.
Protein: RL3_THEPX
Sequence: MKKGILGRKHGMTQIFDEKGEVIPVTVIEAGPCVVVQKKTVETDGYNAIQVGFGDVKEKRLTKPLIGHFKKAGVPFKRYLREFRLDDISGYEVGSEIKVDIFKPGDRVNVTGISKGKGFAGVVKRYGANRGPMSHGSKYHRRVGSMSATTDPGRTFKGKIMPGHMGHERVTIQNLEVVKVDPELNLLLVKGSVPGPKGSLLIIKDSVKSK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: Y2614_CERS4
Sequence: MDLSGSLLIAMPSMADPRFERSLVLICAHSPDGAMGLVVNKPVEDLSFAGMLEQLNIPRAPNGRDIRVHLGGPMERGRGFVLHSPDYMSVGATMLVSGKFGMTATVDILEALARGQGPSSALMALGYSGWGPGQLEAEVQRNDWLTAEAPSELVFSDDDPGKWTGMLRHMGIDPLTLSSTAGHA
What are the official names of this protein?
UPF0301 protein RHOS4_26140.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RL14E_SULIN
Sequence: MPAIEVGRICVKVKGREAGSKCVIVDIIDDNFVLVTGPKDISGVKRRRVNILHLEPTDKKIDIQKGASDEEVRKKIEEAGLTEYMKERIKIKIPTL
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.