PharMolix/UniProtQA huggingface dataset:
Protein: RFC1_ARATH
Sequence: MSDIRKWFMKAHEKGNGSAPKSTSSKAGPVKNAAETAPIKSEQASEDLETADRRKTSKYFGKDKTKVKDEKEVEAIPAKRKLKTESDDLVKPRPRKVTKVVDDDDDDFDVPISRKTRDTTPSKKLKSGSGRGIASKTVDNDDDDDGEDKETPLKSAGRGRGGRAAPGASTGGRGRGGGRGGFMNFGERKDPPHKGEKEVPEGTPDCLAGLTFVISGTLDSLEREEAEDLIKRHGGRITGSVSKKTTYLLCDEDIGGRKSEKAKELGTKFLTEDGLFDIIRSSKPVKKSLPERSNKGTEKICAPPKTSPQKEETRGKPLAKSSPKKVPPAKGKNKIIETSLPWTEKYRPKVPNEIVGNQSLVTQLHNWLSHWHDQFGGTGSKGKGKKLNDAGSKKAVLLSGTPGIGKTTSAKLVSQMLGFQAVEVNASDSRGKANSNIAKGIGGSNANSVKELVNNEAMAANFDRSKHPKTVLIMDEVDGMSAGDRGGVADLIASIKISKIPIICICNDRYSQKLKSLVNYCLPLNYRKPTKQQMAKRLMHIAKAEGLEINEIALEELAERVNGDIRLAVNQLQYMSLSMSVIKYDDIRQRLLSSAKDEDISPFTAVDKLFGYNGGKLRMDERIDLSMSDPDLVPLLIQENYLNYRPSGKDEAKRMDLLARAAESIADGDIINVQIRRYRQWQLSQSCCVASSILPASLLHGSREVLEQGERNFNRFGGWLGKNSTAGKNRRLMEDLHVHVLASRESSAGRETLRVDYLPLLLSRLTSPLQTLPKDEAVSEVVDFMNSYSISQEDFDTILELGKFKGRENPMEGVPPPVKAALTKKYNEMNKTRMVRVADMVQLPGVKKAPKKRIAAMLEPTVDSLRDEDGEPLADNEEGNGSDAEEDSEEATDGEKLESNLKNLNARGIQVELDLKGAGSSGSRKAAGKGRGRGKAADTSAEKKATGRGSGAKRKR
What is the function of this protein?
Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation.  Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination.  May participate in the RAD51-mediated recombination intermediate repair process.  Is important for lagging strand synthesis.  Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates.
What are the official names of this protein?
Replication factor C subunit 1, AtRFC1, Activator 1 large subunit, Activator 1 subunit 1.
What is the protein family that this protein belongs to?
Belongs to the activator 1 large subunit family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to the chromosomes during zygotene and pachytene.
Protein: EGCSE_HYDVU
Sequence: MISVALIILFLAKVISGKSDDFISVNPETNMLIDGYGRERFFHGTNVVVKHFPFHPETTGFNKDTFSEDDMKILQKFGLNSIRLGMMLPGYVPKREEYNETYIKVIQSIVTTAAKYGIYTLLDMHQDVFSPKFCVEGMPDWIVNTQGAKDFPMPLHKPFNLDPKTGYPYPEDCAKFSWADYYFTEAAGQAFQNLYDNVDGLRDEWAQFWKKTADVFKEEPSVIGYELINEPFCGNVFKHPTLLIPGVADYLNLQPTYDALQKAIRQVDEEHNIFFEGVTWDFFEVGFTEVPGGKQYQNRSVLSYHYYEPPDFSKKLNFEARLLDLKRLKCGGFLTEMFTVGTDFNSMFEMFDLCDKFKQSWHGWMYKSYGCIEQNLGCLNMSSPGKESIQIANTSRTYPQAVAGRTQSYAFDIKTKVFTLVYETVGSCKSGRTIVYFNKNLHYPNGYRYEINPNFKVTPSENEYFLYLDEVNKVPNTVVTFKLFPLSFTDSEDIHPVTVMGDKHLSENHNENEKKKK
What is the function of this protein?
Hydrolysis of the glycosidic linkage between oligosaccharides and ceramides of glycosphingolipids, optimal substrates appear to be the glycosphingolipids with a gangliotetraose structure.
What are the official names of this protein?
Endoglycoceramidase, EGCase, Glycosphingolipid-specific enzyme, GSL-specific enzyme.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: RL27_ANADE
Sequence: MAHKKGQGSSRNGRDSPGQRRGIKVYGSEKVVAGNILVRQVGTLVHPGQNVGMGKDFTLFALIDGTVKYSRTRGDRRVVSVLPGA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NDOC_RALSP
Sequence: MMINTQEDKLVSAHDAEEFHRFFVGHDSDLQQEVTTLLTREAHLLDIQAYNAWLEHCVAPEIKYQVISREFRSTSERRYQLNDAVNIYNENYQHLKVRVEHQMDPQNWANSPKIRFTRFVTNVTAAKDKIVPDLLHVRSNLILHRARRGNQVDVFYATREDKWKRIEGGGIQLVERLVDYPERILQTHNLMTFL
What is the function of this protein?
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene (PubMed:9573207, PubMed:11872705).  Also able to use styrene as substrate (PubMed:11872705).  The beta subunit seems to have a structural role in the holoenzyme.
What are the official names of this protein?
Naphthalene 1,2-dioxygenase system, small oxygenase component, ISP NAP, Naphthalene 1,2-dioxygenase ISP beta, Naphthalene 1,2-dioxygenase subunit beta, ND subunit beta, NDO subunit betaa.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: GLUC_ANAPL
Sequence: HSQGTFTSDYSKYLDTRRAQDFVQWLMST
What is the function of this protein?
Glucagon plays a key role in glucose metabolism and homeostasis.  Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
What are the official names of this protein?
Glucagon.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRJ37_CRYJA
Sequence: MATVSDLALLLVAGLVAISLHMQEAGAVKFELKNQCEYTVWAAGLPGGGQQLDQGQTWPVEVPAGTKGARFWGRTGCSFDASGRGTCKTGDCNSQLSCQVSGGVPTTLAEYTLNGDGNKDFYDVSLVDGFNVPLSINPTNSQCFAPACKADVNAACPAQLKVDGGCNSACTVFQTDEYCCRGTHVDNCSPSSYSMIFKNQCPQAYSYAKDDSSSTFTCPSGTTDYSIVFCP
What is the function of this protein?
May be involved in disease resistance.
What are the official names of this protein?
Pathogenesis-related thaumatin-like protein 3.7.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
Protein: TCSA_LISMO
Sequence: MKKRTFALALSMIIASGVILGACGSSSDDKKSSDDKSSKDFTVAMVTDTGGVDDRSFNQSAWEGLQKFGKANDMEKGTDGYNYLQSASEADYKTNLNTAVRSDYDLIYGIGYKLKDAIEEVSKQKPKNQFAIVDDTIDDRDNVVSIGFKDNDGSYLVGVVAGLTTKTNKVGFVGGVKGTVIDRFEAGFTAGVKAVNPNAQIDVQYANDFAKADKGQQIASSMYSSGVDVIFHAAGGTGNGVFAEAKNLKKKDPSRAVWVIGVDRDQWDEGKVTANDGKDYNVTLTSEIKRVDIAVEDLATRAKAGDFPGGTKIEYGLDKDAVGLSEHQDNISKDVLAKVEEYKQKIVDGDIKVPEKP
What are the official names of this protein?
CD4+ T-cell-stimulating antigen.
What is the protein family that this protein belongs to?
Belongs to the BMP lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: NTP1_RFVKA
Sequence: MSVHHAAYIDYALRVTENMTDVMTGSDTVTLKSYQHFVSRVFLGLDKMHSLLLFHETGVGKTITTVFILKHLKDVYTNWIIILLVKKALVEDPWTYSITKYAPEILKDCIFITYDDKNFHNKFFTNIKTISSRSRLCIIIDECHNFISKSIVKEDGKQRPTKSVYNYLLKNVALHHHKLICLSATPIVNSVKEFIMLVNLLRPKILNNISLFENKRLINESELINKLGAICSYIVTNEFSIFDDVEGSATFAKKNVYFQYVNMTQKQEQVYQKAKSAELKAGTSSFRIYRRMAATFTFDTFLDKTDKTPEEIVNEQVTLYKDFEKFIKTKKFSDHALSHFKKGQSLNGTSSADDISFLNELREHSCKFTDVCLRILASPGKCLVFEPFVNQSGINILLLYFSAFNISYIEFSSRTKNTRVQSVAEFNKRENTNGDLIKTCVFSLSGGEGISFFSINDIFILDMTWNEASLRQIIGRAIRLNSHVLTPEHRRYVYVHFIIARLSNGDPTVDEDLLDIIRNKSKEFTQLFKVFKHTSIEWIYEHQTNFSPVDDESGWGALISRSIDENPTTKRVPRIARGQNIWYSHSNRMITVYKGFKTDDGRLFDSDGNFIQTIQANPVIKIHNNKLVYVLD
What is the function of this protein?
DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts.  Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex.  NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity).
What are the official names of this protein?
Nucleoside triphosphatase I, NPH-I, Nucleoside triphosphate phosphohydrolase I, NPH I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. NPH I subfamily.
What are the subcellular locations of this protein?
Virion. Note=Virion core enzyme.
Protein: SSRP_BURP1
Sequence: MSIIDNRKAFFDYHIEERYEAGLVLEGWEVKALRAGRGQIKEGYVVVKHAEIFLIGTHISPLPEASTHIKPDPVRTRKLLLHRDEIKKLIGKVEQRGYTLVPLNFHYKGGRVKCEIGLAKGKKLHDKRETEKKRDWEREKARIMRSAT
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ARBK2_BOVIN
Sequence: MADLEAVLADVSYLMAMEKSKATPAARASKKIVLPEPSIRSVMQKYLEERHEITFDKIFNQRIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLENEEDRLCRSRQIYDTYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGSIFQKFMESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDVFSPELKSLLEGLLQRDVSKRLGCHGGSAQELKTHDFFRGIDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVAETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGRDCIVHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSLLTMEQIVSVEETQIKDKKCILLRIKGGKQFVLQCESDPEFVQWKKELTETFMEAQRLLRRAPKFLNKSRSAVVELSKPPLCHRNSNGL
What is the function of this protein?
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
What are the official names of this protein?
Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
What are the subcellular locations of this protein?
Postsynapse. Presynapse.
Protein: EFG1_BORGP
Sequence: MDYNKLRNIGISAHIDSGKTTLTERILFYCNKIHAIHEVKGKDGVGATMDSMELERERGITIASAATHVEWKDFPINIIDTPGHVDFTIEVERSLRVLDGAILVLDSVAGVQSQSITVDRQLKRYSVPRLAFVNKCDKTGANPYNVRDQLRSKLDLNSVLMQIPIGLEDKHIGVIDLVLMKAYYFEGKDGTEIIEKEIPSDLLGEAKKKREIMLDALADFNDELMELHMEGKDVPIEIICNAIRTGTLALKLCPVFMGSAYKNKGVQLLLDAVTRFLPSPHDIKNTALDINNNEKEIDLKIDNDLPTVALAFKLEDGQYGQLTYVRIYQGTLRKGQELINSRTSKKFKVGRLIRMHANNTEDIEFGGSGDIVALFGIECASGDTFCDPSINYSMTSMFIPDPVISLSVKPKDKKSADNMAKALGRFTKEDPTFKTYVDIESNETIIQGMGELHLEVYIERMKREFKAEVETGMPQVAYRETITGKAEFNYTHKKQSGGAGQFGRVAGFMEPLNKEGETYEFVNLIKGGVIPTEYIPSCDKGFQKAMEKGTLIGFPIVDIKITINDGQYHIVDSSDIAFQLAAIGAFREAYEKAKPTILEPIMKVTLEGPTEFQGNMFGLLNQRRGIITGSLEDGSFSKVEAEVPLSEMFGFSTVLRSSTQGKAEFSMEFLKYGKVPNAIFDELRKKFNDQNKS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNA_KLEP7
Sequence: MKAVVFAYHDMGCTGIQALLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPEDVNHPLWIERIREMKPDVLFSFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWVLVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALTLHRKLCAAATELLSRALPAILAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKFIVWKSRVRHDLPAAKPGTVLSIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVSGAVISSKPVVAIKRRTRVLILGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRDCVKYNKRIIFPSTSEVYGMCTDKNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDKNGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDISDGIEALFRIIENKDGRCDGQIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGFREVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEETVEHTLDFFLRTVELVDDKNP
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: MDTP_ECOLI
Sequence: MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYSMDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLATGVAQLYYSMQASYQMLDLLEQTHDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVDKQIVAVKGQITETRESLRALIGAGASDMPEIRPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDSIHLHTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQAGPVVEKK
What is the function of this protein?
Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
What are the official names of this protein?
Multidrug resistance outer membrane protein MdtP.
What is the protein family that this protein belongs to?
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RD3_MOUSE
Sequence: MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD
What is the function of this protein?
Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:27471269).  Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:27471269).  Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983).  Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP (By similarity).  Plays an important role for the survival of rods and cones in the retina (PubMed:8486383, PubMed:17186464).
What are the official names of this protein?
Protein RD3, Retinal degeneration protein 3.
What are the subcellular locations of this protein?
Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (PubMed:29515371). Strong dot-like perinuclear staining in the epithelial cells (By similarity).
Protein: EFP_LARHH
Sequence: MKIAQELRSGNVFMLDGQPMVVQKTEYNKSGRNAAVVKMKMKNLLTGSASEAVYKADEKFDIVVLDKKECTYSYFADPMYVFMDGEFNQYEVEAENMEDVLPFLEDGMTDPCEVVFYEGRAISVELPTTVVREVEYTEPAVRGDTSGKVLKPARLHNGTVIQVAAFVEIGDKIEIDTRTSEFKKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHK1_CHICK
Sequence: MAVPFVEDWDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAADCPENIKKEICINKMLNHENVVKFYGHRREGATQYLFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGITHRDLKPENLLLDERDNLKISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAGELPWDQPSDSCQEYSDWKERKTYLAPWRKIDSAPLALLHKILTENPTARITIPDIKKDRWYCRPLKKGTKRGRVSSGGVTESPGALPKHIRSDTDFSPVKSALGEDKASYSTSQPEPGTGGALWDSSTGSIDRLVQGISFSQPACPEHMLLNSQLLGTPGSSQSPWQRLVRRMTRFFTKLDADGSYRSLRDVCEKMGYGWKQSCTNQVTISTTDRRNNKLIFKVNLLEMESRILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSTQKVWLPPP
What is the function of this protein?
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:12554671).  May also negatively regulate cell cycle progression during unperturbed cell cycles.  This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome.  Recognizes the substrate consensus sequence [R-X-X-S/T].  Binds to and phosphorylates CDC25A, CDC25B and CDC25C.  This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family.  Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.  May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression.  May also play a role in replication fork maintenance (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint kinase-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: CYF_MANES
Sequence: MQTRKTFSWIKEEITRSISVLLMIYIITWASISNAYPIFAQQGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVVRIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEMKEKMGNLSFQSYRPTKKNILVIGPVPGQKYSEITFPILSPDPAAKKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAAGIVSKIIRKEKGGYEITITDASEGRQVIDIIPPGPELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLASVILAQIFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RBL_AURMS
Sequence: MDQGSQTIKGKDRYKSGVMEYRKMGYWEPDYEPKETDVIACFRITPQDGVDPIEAAAAVAGESSTATWTVVWTDRLTAAEKYRAKAYRVDQVPNTDDQYFAYIAYDLDLFENGSIANLTASIIGNVFGFKPLKGLRLEDMRLPTAYVKTFQGPATGIVVERERLDKFGRPLLGATVKPKLGLSGRNYGRVVYEALKGGLDFTKDDENINSQPFMDWRERFLYCMEAVNKAQAATGEIKGTYLNVTAATMEDMYERAEFARDLGSNIIMIDLVIGWTAMQSMAKWARRNNMILHLHRAGHSTYTRQKTHGVSFRVIAKWARLAGVDHIHAGTVVGKLEGDPATTKGYYDICRDEFTHRKLENGIFFDQPWASLNKMMPVASGGIHAGQMHQLLDLLGDDTVLQFGGGTIGHPMGIAAGATANRVALECMVLARNEGRDIVNEGPEILQEAARSCTPLQQALETWKDVTFNYTSTDSPDYAVTATASV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: NQO10_THET8
Sequence: MSLLEGLALFLLLLSGVLVVTLRNAIHAALALILNFLVLAGVYVALDARFLGFIQVIVYAGAIVVLFLFVIMLLFAAQGEIGFDPLVRSRPLAALLALGVAGILAAGLWGLDLAFTQDLKGGLPQALGPLLYGDWLFVLLAVGFLLMAATVVAVALVEPGKASRAKEAEKREEVAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit 10, NADH dehydrogenase I chain 10, NDH-1 subunit 10.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFTU_MAGMM
Sequence: MAKEKFARTKPHVNIGTIGHVDHGKTTLTAAITKVMAAAGRAEFRAYDQIDGAPEERERGITISTAHVEYETEARHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLARQVGVPALVVFLNKVDQVDDEELLELVEMEVRELLSSYDFPGDDIPVIKGSALKALEGEESEMGVDAINRLMDAVDAYIPEPERPLDQAFLMPIEDVFTISGRGTVVTGRIERGIVKVGEQVAIIGIKDTVVTTCTGVEMFRKLLDQGQAGDNVGVLLRGTKREDVQRGQVLAAPNSIKPHTKFNAESYILTKEEGGRHTPFFSNYRPQFYFRTTDVTGVLKLPEGVEMVMPGDNITMEVELIAPIAMEKGLRFAIREGGRTVGAGVVAEVID
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFU3_ARATH
Sequence: MGSVSGQTRITTMNLSLSTAEKNPNFRSSLLNSKNAISDTLGVSSKCSTFLRGQFQRIHFSWLQHTRPLRKRTVFGHVSCVMPLTEENVERVLDEVRPSLMADGGNVALHEIDGLVVVLKLQGACGSCPSSSMTLKMGIESRLRDKIPEIMSVEQFLESETGGLELNDENIEKVLSELRPYLSGTGGGGLELVEIDGYVVKVRLTGPAAGVMTVRVALTQKLRETIPSIGAVQLLE
What is the function of this protein?
Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins.
What are the official names of this protein?
NifU-like protein 3, chloroplastic, AtCNfu3, AtCnfU-IVa.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: FB246_ARATH
Sequence: MEKNQNPNTWSDLPLDLLNLVFKRLSFANFRQAKSVCSSWYSASKQSVPKNQIPWLMLFPKDKNNNKNSSCTIFFNPEDKDQLYQTQDLGVEFAKSVCLATYGSWLLMQDSKYNLYILNPFTYEKIGLPAIESQQVGMVKVDQTIDDDFLTFDDHNHVKLFKGNNTVRTPVFWIDEKTKEYIALWGLGYWCVVYAKNGDKLWNQIPEIILDSLDMVYKDHKLYSFSYRNLFTILDFSGEIPRKAFQCFMHVYRSEWLSPRSRQLSNSWCVAETKLVVTVTGDVLLVERMLRHWSRIQSFNVYKFYSSGTFLDKYELADSLGDEAMLLDLGITVLANEVEGLHRNTIYFSDSHDTTTKDLFLFNYETREMEPLHKFDFDCSLLELSARWFLPSFSHT
What are the official names of this protein?
Putative F-box protein At4g22660.
Protein: HIS2_METCA
Sequence: MDVLHRLAEILEQRKTEAPDKSYAASLYAKGLDTILKKIGEEATETVIAAKDGEPGKIVYEMADLWFHCCVLLAQQGLGPDDVLRELGRRFGMSGLEEKASRKLG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_ECOLC
Sequence: MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACVALADALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAICDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.