PharMolix/UniProtQA huggingface dataset:
Protein: LIPA1_PHATC
Sequence: MWSSSSSLCRNPSFRRAWLSTVTVTQTAAPTSSRLAALRTQLATEEASIDDFSSTNAPTTTTHYTSSNGSPIVRQKAAPRSAKILPKPRWLKAAPATSDNYRKLRDTVRELGLATVCEEARCPNIGECWGGGEDQTATATIMIMGDTCTRGCRFCSVKTSRAPPPLDPHEPEKVATAIAQWGLDYVVLTSVDRDDLPDQGADHFRQVVTQLKLKKPSLLVEALTPDFQGNMDLVHAVATSGLDVYAHNMETVEALTPKVRDRRATYRQSLEVLRYVKTIQSDPIGTTNNHNNNNGCLTKTSLMLGLGETDDQVLTTLRDLRDADVDVVTFGQYLQPTKKHLPVQEYVTPEKFDFWQETAMGMGFAYVASGPLVRSSYKAGELFLQKYIAQKKQRNAEVAAA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase 1, mitochondrial, Lipoate synthase 1, LS 1, Lip-syn 1, Lipoic acid synthase 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MGSA_BACMK
Sequence: MKIALIAHDKKKDDMVSFAYAYKPIFEKHELFATGTTGLRIMEATGLVVTRYQSGPLGGDQEIGAMIAKNEMDMVIFFRDPLTAQPHEPDVNALLRLCDVYAIPLATNMASAEMLMHALERGDLDYRKLRK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: ODBA_RAT
Sequence: SAAKIWRPSRGLRQAALLLLGRPGARGLARFHPSRQQQQQFPSLDDKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKLYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANQIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFDK
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDE1A, BCKDH E1-alpha.
What is the protein family that this protein belongs to?
Belongs to the BCKDHA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NKX32_MOUSE
Sequence: MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRARVTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGAAGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ
What is the function of this protein?
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation.  PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium.  In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
What are the official names of this protein?
Homeobox protein Nkx-3.2, Bagpipe homeobox protein homolog 1, Homeobox protein NK-3 homolog B.
What is the protein family that this protein belongs to?
Belongs to the NK-3 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_CHLTB
Sequence: MIHVTCNQEAFELPEGASAMDLANKMKQSHCFVGALINDQEKDLSTTLQDGDTVLFLTWDDPKGREIFLHTSAHILAQAVLRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMAKTIAEEKFPISRQVFPDKEAALAYFSQNPFKAELIAELPEEVEISAYTQGEFLDLCRGPHLPSTAPVKAFKLLRTSSAYWKGDPSRESLIRIYGVSFPTTKELKEHLHQLEEAKKRDHRVLGTKLDLFSQQTCSAGMPFFHPRGMVVWNALVDYWKRLHQRAGYQQIQTPQLMNRELWEISGHWENYKENMYTLTVDEEDYAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHELSGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSELYGTFGLEYHLELSTRPEQGTIGSDDLWELATEALKRALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLDMFLPERFDLKYTNAQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIITVADRHEARAQELAKHFSQMGIIVSVDSSNESVSKKIRNAQNMQVNYMITIGDKELETHLLAVRTRDNRVLNDIAVEQFSHVILEELRSLSLTPSL
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1628_PSESM
Sequence: MLNYLWFFLAALFEIAGCYAFWLWLRQGKSALWVIPALISLTLFALLLTRVEAAYAGRAYAAYGGIYIVASIAWLGLVERVRPLGTDWLGLAFCVIGATIILLGPRWSAP
What are the official names of this protein?
UPF0060 membrane protein PSPTO_1628.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KUP2_RHIME
Sequence: MADSLDHAPAQANNLPQFLALTIGAIGVVYGDIGTSPLYAFREALRPFGPGGVGRDEVIGLVSLVLWTLTAIVTIKYVLFLLRADNDGEGGTLSLLALLLKKGTKYPVLMFFAGVLGAALFIGDAMITPALSVLSAVEGLKLVAPALHDYVLPISVVIILLLFAVQSRGTGAVSVFFGPITLVWFLMMAAAGVAHIGDDLAILSAFNPLNAIGFLWNAGLIGFIVLGAIFLTVTGAEALYADLGHFGRHSIQAAWFAVVFPALALNYLGQGALVLSHPDAISNPFFLMFPNWALLPMVILATAATIIASQSVITGAFSLIRQAIHLGFLPRFEICYTSETQTGQIYLPLVNTILLTGVLALMLMFGSSEALAPAYGVSITGAMVIDTILAFEFVRRQWGWPALTAIAVLLPLFNLELVFLGANLLKVHHGGYVPILIAGTLITMMWTWRKGVSVLREKTARQDIPLSQFMAIVERKSEHAPVQVPGTAIFLTATPDTTPAVLLHNIKHNHVLHQHNVIMTIKTARVPYVPEKDRYTITKLSDRFSLLELRFGFMDDQNVSRALARCRKEGFKFEIMSTSFYLGRRKLIADPQSGLPQWQDKLFIAMADSAIDPTEYFHLPANRVVELGEQVII
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_PHYMT
Sequence: MYSYIKGKVVNNGQNFVIVDNNNIGYHIIVSNPYFYEINKEYKFFVHFHIKENLQILYGFNDNKNLLFFKKLLDVPTIGPKSALMLSETDNLEQVFQAIENNDNVYLRKFPGIGIKSAQQIILKLKGDLIFSEKIILNPKKTELEKILLNLGFVKKEIKSVLNQIDDKKELELMLKEVLLKLAKNI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PSBT_EUGGR
Sequence: MEALVYTFLLIGTLGVIFFAIFFRESPRINK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CEAN_ECOLX
Sequence: MGSNGADNAHNNAFGGGKNPGIGNTSGAGSNGSASSNRGNSNGWSWSNKPHKNDGFHSDGSYHITFHGDNNSKPKPGGNSGNRGNNGDGASAKVGEITITPDNSKPGRYISSNPEYSLLAKLIDAESIKGTEVYTFHTRKGQYVKVTVPDSNIDKMRVDYVNWKGPKYNNKLVKRFVSQFLLFRKEEKEKNEKEALLKASELVSGMGDKLGEYLGVKYKNVAKEVANDIKNFHGRNIRSYNEAMASLNKVLANPKMKVNKSDKDAIVNAWKQVNAKDMANKIGNLGKAFKVADLAIKVEKIREKSIEGYNTGNWGPLLLEVESWIIGGVVAGVAISLFGAVLSFLPISGLAVTALGVIGIMTISYLSSFIDANRVSNINNIISSVIR
What is the function of this protein?
Colicins are polypeptide toxins produced by and active against E. coli and closely related bacteria.
What are the official names of this protein?
Colicin-N.
What is the protein family that this protein belongs to?
Belongs to the channel forming colicin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DMXL1_HUMAN
Sequence: MNLHQVLTGAVNPGDHCFSVGSIGDQRFTAYASGCDIVILGSDFERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVISIFEPVNLPKQKKNLELYSQWQKSGQFFLESIAHNITWDPTGSRLLTGSSYLQLWSNTNLEKPTEDENLNKTDLNFGDWKCIWHCKTASQVHLMKFSPDGEFFATAGKDDCLLKVWYNVENWRTAVTSPDGSSEKQSQGEIDFSFVYLAHPRAVNGFSWRKTSKYMPRASVCNVLLTCCKDNVCRLWVETFLPNDCLLYGGDCSHWTESINLTNNFKRNASSKERVQNALEVNLRHFRRGRRRSLALVAHTGYLPHQQDPHHVHRNTPLHANALCHFHIAASINPATDIPLLPSITSLSLNENEEKTGPFVVHWLNNKELHFTLSMEVFLQQLRKSFEQPSSEASVEDSNQADVKSDEETDDGVDDLKINPEKKELGCDKMVPNSSFTSLSSAAIDHQIEVLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCKSIMMYACTKNVDLAIQQGKQKPSGLTRSTSMLISSGHNKSSNSLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTVLSISHKSRYCGHRFHLNDLACHSVLPLLLTTSHHNALRTPDVDNPEQPFDALNIEECSLTQQNKSTVDVAFQDPSAVYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFSNVAWLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAKKLLSELSNPEISKYVGEVFNIVSQQSTARPGCIIALDPITKLHGRKTQLLHVFEEDFILNNLEKKSLGKDSILSNAGSSPNGFSEKFYLIVIECTQDNRSLLHMWNLHLKSIPVSLDEKVDTKLSEAVWQPEEHYSSSPEKILSPFSQKYQACRANLQSTSRLTLFSEMVYSQELHLPEGVEIISIKPSAGHLSSSSIYPACSAPYLLATSCSDEKVRFWRCRVTDGESATSKNGKIDLAYIWEEWPLLIEDGLQSNSSITVPGRPVEVSCAHTNRLAVAYKQPASNSRSSQDFVMHVSIFECESTGGSCWVLEQTIHLDELSTVLDSGISVDSNLVAYNKQDMYLSSKENITSNTKHLVHLDWMSREDGSHILTVGIGSKLFMYGPLAGKVQDQTGKETLAFPLWESTKVVPLSKFVLLRSVDLVSSVDGSPPFPVSLSWVRDGILVVGMDCEMHVYCQWQPSSKQEPVITDSYSGSTPSITSLIKQSNSSSGLHPPKKTLTRSMTSLAQKICGKKTAFDPSVDMEDSGLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNHERRLRSLTISASGSTTRDPQAFNKAENTDYTEIDSVPPLPLYALLAADDDSCYSSLEKSSNESTLSKSNQLSKESYDELFQTQLLMTDTHMLETDEENTKPRVIDLSQYSPTYFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTFLTTSLPAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRKCIEKVAKAAFYRKNDPLDAAIFYLAMKKKAVIWGLYRAEKNTRMTQFFGHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVIARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYLRTHPLLLRRHFGSSDTFSTHMSLTGKSGLAGTINLSERRLFFTTASAHLKAGCPMLALEVLSKMPKVIKKTRPFYRASSFLDTSKDCSPSSPLKLDAREDKSSAVDWSQSLINGFGSSSEGSSEKQSNSTLSFDWSQPSVVFQDDSLELKWDSDNDEENEDVPISMKELKPLQRKTDKKLDDISSNYTESFSTLDENDLLNPSEDIIAVQLKFRACLKILTVELRTLSTGYEIDGGKLRYQLYHWLEKEVIALQRTCDFCSDAEELQSAFGRNEDEFGLNEDAEDLPHQTKVKQLRENFQEKRQWLLKYQSLLRMFLSYCILHGSHGGGLASVRMELILLLQESQQETSEPLFSSPLSEQTSVPLLFACTANAKTVVANPLLHLSNLTHDILHAIINFDSPPHPDIQSNKVYVMHTLAASLSACIYQCLCGSHNYSSFQTNQFTGMVYQTVLLPHRPSLKTGSLDEALTPNTSPAQWPGITCLIRLLNSSGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSSNELFRIVAHPLNEKMWSAVFGGGAHVPSKEQTHSKTLPVSSLVEEGEKQNKRFRPSKMSCRESAPLTPSSAPVSQESLAVKEKFIPPELSIWDYFIAKPFLPSSQSRAEYDSEESLGSDDDDNDDDDDVLASDFHLQEHSNSNSYSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSSPLCHAVLKTLQCWEQVLLRRLEIHGGPPQNYIASHTAEESLSAGPAILRHKALLEPTNTPFKSKHHLALSVKRLWQYLVKQEEIQETFIKNIFTKKRCLNEIEADLGYPGGKARIIHKESDIITAFAVNKANRNCIAIASSHDVQELDVSGILATQVYTWVDDDIEVETKGSEDFLVIHARDDLTAVQGTTPYTHSNPGTPINMPWLGSTQTGRGASVMIKKAINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTGSMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARQSIFRNIGTGVMQIETGPANHIFSCGADGTMKMRILPDQFSPLNEVLKNDVKFML
What are the official names of this protein?
DmX-like protein 1, X-like 1 protein.
Protein: PURA_METM6
Sequence: MTCTIVVGGQWGDEGKGKIISYLCKKDNPSIIARGGVGPNAGHTVEVDGEKYGIRMVPTGFPNVNAKLAVGAGVLTDPEVLLKEIQMLEKFNVGERMLVDYRCGIIEETHKELDKSNEHLSKEIGSTGTGCGPANVDRAMRTLKQGKDIESISKYMGDVSKAVNEALEAGDNVLIEGTQGSLLSLFYGSYPYVTSKDTNAASFAADVGVGPTKIDEVVAVFKSYPTRVGEGPFPTEMSVEEAESLGVVEYGTVTGRRRRVGYFDHELAKKVCRLNGATQIAITCLDKYDTECYGITEYEKLSEKGKAFIKEVEEKVGVKVTLISTGPELGQTIDVRK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_MOUSE
Sequence: MSEPELKLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIRLLASHLKSTHSGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKQGKLPGPTVSASYSLEYGKAELEIQKDALEPGQRVVIVDDLLATGGTMFAACDLLHQLRAEVVECVSLVELTSLKGRERLGPIPFFSLLQYD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CR22_RANCA
Sequence: GLVSSIGRALGGLLADVVKSKEQPA
What is the function of this protein?
Antimicrobial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes.  Each caerin displays a different antimicrobial specificity.
What are the official names of this protein?
Caerin-2.2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Caerin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PIMT_SALG2
Sequence: MVSGRVQALLEQLRAQGIRDEQVLNALAAVPREKFIDEAFEHKAWENIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWQARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMAQLDEGGILVLPVGDEQQFLKRVRRRGGEFIIDTVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDRD7_PONAB
Sequence: MLEGDLASKMLRAVLQSHKNGVALPRLQGEYRSLTGDWIPFKQLGFPTLEAYLRSVPAVVRIETSRSGEITCYAMACTETARIAQLVARQRSSKRKTGRQVNCQMRVKKTMPFFLEGKPKATLRQPGFASNFSVGKKPNLAPLRDKGNSAVVKPDAEISPCMLHTTLGNEAFKDIPVQRHVTMSTNNRFSPKASLQPPLQMHLSRTSTKEMSDNLNQTVEKPNVTPPASYTYKMDEVQNRIKEILNKHNNGIWISKLPHFYKELYKEDLNQGILQQFEHWPHICTVEKPCSGGQDLLLYPAKRKQLLRSELDTEKVPLSPLPGPKQTPPLKGCPTVMAGDFKEKVADLLVKYTSGLWASALPKAFEEMYKVKFPEDALKNLASLSDVCSIDYISGNPQKAILYAKLPLPTDKIQKDAEQAHGDHDIKAMVEQEYLQLEENIAESANTFMEYITVPPLMIPTEASPSVLVVELSNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKVTPVQAVNVGQLLAVNAEEDAWLRAQVISTEENKIKVCYVDYGFSENVEKSKAYKLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTCGKIFAVEILDKADIPLVVLYDTSGEDDININATCLKAICDKSLEVHLQVDAMYTNVKVTNICSDGTLYCQVPCKGLNKLSDLLRKIEDYFHCKHMTSECFVSLPFCGKICLFHCKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSELREIPPRFLQEMIAIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKVDETRGIAHVYLFTPKNFPDPHRSINRQITNADLWKHQKDVFLSAISSGAGSPNSKNGNMRVSGDTGENFRKNLTDVIKKSMMDHTSSFSTEELPPPVHLSKPGEHMDVYVPVACHPGYFVIQPWQEIHKLEVLMEEMILYYSVSEERHIAVEKDQVYAAKVENKWHRVLLKGILTNGLVSVYELDYGKHELVNIRKVQPLADMFRKLPFQAVTAQLAGVKCTQWSEEASMVFRNRVEKKPLVALVQTVIENANPWDRKVVVYLVDTSLPDTDIWIHDFMSEYLIELSKVN
What is the function of this protein?
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation.  Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens.  Also required during spermatogenesis (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the TDRD7 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic RNA granules (By similarity). Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).
Protein: SPAST_IXOSC
Sequence: MASTVALLRDSSDDRENFDDGETDCVQVGRKRKLTVFFYPLLLVFWLLRWVFYQFFLVLCFVCRGFVPRRHLATAETTTTMATAEEPDANLLIRQKQHHKKAFDFISKALKYDEENEDFKEMSIDLYRKGIEELQKGIAIDFSKGQGTTWERAHRLSDKMKVNLEMARDRLDFLESMVKIEHLGDHLPWHGGVAPAQRGQRRRAWQKAAPSAPSEPGTGPSWLKMAENGPAKGGPCPTSPRLQRSNTGVTLRRQQQQQLGGVSTVSRSQTLPRNSVPCPRMSARSPSRKAGNNEAVPTPNTARRRASQPQVPPVHPRGRQPTTRGGAAHRGGPPTVSQRSLLSSRVPPLKGVDSRLAHLILDEVVDGAPPVLFSDIAGQEVAKQALSEMVILPTDRPELFTGLRAPPKGLLLFGPPGNGKTMLAKAVAHESNSTFLNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLSERKDNEHEATRRLKTEFLVEFDGLHTGSEERVLVMGATNRPQELDDAALRRFTKRVYVTLPDHNTRVILLEKLLKKHNNPLSADKLKYLARLTEGYSGSDLTALAKDAALGPIRELNPEQVRCVDPKKMRNISLQDFLDSLKKVRRSVTPQSLDFFDRWNREFGDITV
What is the function of this protein?
ATP-dependent microtubule severing protein.  Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Forms an intramembrane hairpin- like structure in the membrane.
Protein: PCHA_PSEAE
Sequence: MSRLAPLSQCLHALRGTFERAIGQAQALDRPVLVAASFEIDPLDPLQVFGAWDDRQTPCLYWEQPELAFFAWGCALELQGHGEQRFARIEENWQLLCADAVVEGPLAPRLCGGFRFDPRGPREEHWQAFADASLMLAGITVLREGERYRVLCQHLAKPGEDALALAAYHCSALLRLRQPARRRPSGPTAGAQGDASAQERRQWEAKVSDAVSSVRQGRFGKVVLARTQARPLGDIEPWQVIEHLRLQHADAQLFACRRGNACFLGASPERLVRIRAGEALTHALAGTIARGGDAQEDARLGQALLDSAKDRHEHQLVVEAIRTALEPFSEVLEIPDAPGLKRLARVQHLNTPIRARLADAGGILRLLQALHPTPAVGGYPRSAALDYIRQHEGMDRGWYAAPLGWLDGEGNGDFLVALRSALLTPGRGYLFAGCGLVGDSEPAHEYRETCLKLSAMREALSAIGGLDEVPLQRGVA
What is the function of this protein?
Involved in the conversion of chorismate to salicylate.
What are the official names of this protein?
Salicylate biosynthesis isochorismate synthase, Isochorismate mutase.
What is the protein family that this protein belongs to?
Belongs to the isochorismate synthase family.
Protein: RT106_NEUCR
Sequence: MAAKLDSQLLGLVFQSRPDILKGIQEAADSPARIDLFNNIASFVYERIADNTSEEPATKRRRVEAQTSGPNGAAHPIAGSQAAVLGADAAAAEPVLLEIKDISVSVPQRKKYDLCFTKNFLYARASGSPVPVQGIVYPWKDIEHAFYLPVPDKSQVQHNYVLLPRNSYLPTTKSQQSADQQTQQQTSAPLEPLVFTIPSTAPKPGTITGPSAAAAAPVSDSYATLFHWALTTSLHAAGNHACELVSSDPKVFHSVARQAYRPQEKAVHVKAFRGSKDGFLFFLPTGILWGFKKPLLFLPLDKIVAISYTSVLQRTFNIVVELEGGGEGSEEGGQEIEFSMLDQEDYAGIDQSYVRRHGLADRSMAEQRKAKKQLAENAKKAAANGEEGEGGEGGEAGDGLTELERAQKEEEQRLQDEEDEEEEDYDPGSEGESEGSGSSSEEEEEEEDGEGEGDEDDDEDMGEGLEGEE
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone rtt-106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CYSA_LEPIC
Sequence: MGIEVKNLVKRFGNFTAIDDLSLDVPSGELVALLGPSGSGKTTLLRIIAGLEDADKGQVIFEGREVGKKNAKDRGVGFVFQHYALFRHMTIFENIAFGLEVRKRSERPSKDTIRDKVMSLLKLVQLENFYNRYPSELSGGQRQRIALARALAIEPRFLLLDEPFGALDAKVRKELRNWLRRLHDEIHITSVFVTHDQEEALEVSDKVVILRSGKIEQVGTPDEVYNHPKNSFVFHFLGDVNLFHGRVQGGQTQLGEIKVDTPEHSEIENASAVGYVRPYDVEILREPIEAQTIPAEIQYIHSTGRNVKIDLKRLDTGTILESQLNSSEFQSLNLLPGETVHIRFKKIKVYVEDYTI
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CLN3_DICDI
Sequence: MGKDYTFIRNWISFHFMGNINNFSYCVVNAASGNLSAYFHNSKNIGIILWANIAFGLVSRLVNTFLIENVNSKLKIVVNCLFMSIGLIGVALSVYVNFGFCIAAIAFVGIASSFGESVILSYMKKFPAELVNGWSSGTGIAGVCGSLFYIAMVAAGLSNSTIFYMMLPTVAVYFLLFFFGLKVPNHLEEDRTDNHNNSNNSSNNSKYTEKQSLVKKDQLIEDIDDGGGAEVAPPGETKKQRYIRCARLVWFNAVNLALVYFFEYVASVGGADLALKKDPNNDNFFIANAFAIFSFCYQLGVLISRSSLQFVKIKHIGVITILQGINMVFWIIQAKYKMVTSVWVLFILMVYCGLLGGASYVNVFYLILHQKNIPNEDRELCINYAALLVTVGITLAACFILVMDHTFLASEVPKTDSSSST
What are the official names of this protein?
Battenin, Protein CLN3 homolog.
What is the protein family that this protein belongs to?
Belongs to the battenin family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: CC184_RAT
Sequence: MEDSLLEIMTKDGGDMPAPLEVSTVPAVGDVISGEYNGGMKELMEHLKAQLQALFEDVRAMRGALDEQASHIQVLSDDVCANQRAIVSMCQIMTTAPRQGGLGVAGGKGSFPSVPHEPETPSPGIGDSGLLGRDPDEEDEEEEEEKETASPATPTSHCERSESPGLLGENGPLVEPLDLPDITLLQLEGEASL
What are the official names of this protein?
Coiled-coil domain-containing protein 184.
Protein: LPXK_RALSO
Sequence: MPVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVVVGNVTVGGAGKTPAVIALASALADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPLLIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQHYRLRRDIEIVVFDLRMGGNGFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQFARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITEKDAVKCGHLDDPRIWVVPTTPVVDAALVEQVCRRVRALADRSTSQAGAQ
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: HFLX_FLAPJ
Sequence: MLEKETINFEKTIIVGIVTQNQSEEKLKEYLDELEFLTFTAGGEVVKRFSQKMERPNPKTFLGTGKIEEINLYVLENGISTIVFDDELTPSQQKNISKIIDCKILDRTHLILDIFAQRAETSYARTQVELAQCIYLLPRLSGMWTHLERQKGGIGMRGPGETEIETDRRIVRDRIALLKEKIKIIDKQQATQRGNRGAMVRVALVGYTNVGKSTLMNAVGKSDVFVENKLFATLDTTVRKVVIKNLPFLLSDTVGFIRKLPTQLVDSFKSTLDEVREADLLLHVVDISHQDFEDHIDAVNKILLDIKSADKPTIMVFNKIDAYKHLTIDADDLMTERTSKHYTLQEWKNTWMNKVGEQNALFISATNKENFEEFRKKVYETVREIHITRFPYNKFLYPDYEDAIDKEEEQDQD
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: RS15_NAEGR
Sequence: MAMENDELKNLFTSALRRIIGKGISKKYKTLIEKAQKKRDTAPYGEKPDAVKTHLRDMIILPSMIGCVIGVYQGKDYVSVEIKPEMVGMKLSDFSLTYRPVKHGKPSIGATSSSGFVPLK
What are the official names of this protein?
40S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.