PharMolix/UniProtQA huggingface dataset:
Protein: YHYB_SCHPO
Sequence: MSSQKRADSSSSFDQAERRSLDENERKKKYFFNREGSGIDNFETDDRVNEIINEQNEENVIDQSRWSKLWRIWNVGYSWFILSIIGTTVGFAAYMLDIVTSWLSDIRRGYCTSHWYYNEKFCCWYSETMGSSCTAWKPWTYKFSLNYLIYTAFALLFVLCAAIMVRDVAPLAAGSGISEIKCIISGFLRDSFLSFRVMLVKCVGLPLAIASGLSVGKEGPSVHLATTIGHNISKIFKYAREGSIRYRDICVASAASGVAVAFGSPIGGVLFGIEEMSGGYDPKMIVYSFFCCLSAVGVLHMLNPFRTGQVVLFEVRYSGSWHFFELLFFCFLGIFGGLYGEFVMRLFFLIQKLRKKYLSRWGVLDAAFVTVITSLVSFLNPWLRLDMTLGMELLFQECKSSSSPELINLCDPSLRTKNTILLLIATFARTIFVTFSYGAKVPAGIFVPSMAVGASFGYMIGLIAEMIYQRFPNSVLFLACHGSESCITPGTYALLGAAASLSGIMHLTVTIVVIMFELTGALNFILPTVLVVALANSIGNMLGKTGIADRSIEINGLPLLEPEKSINSSNTINIPITEVMASNLITIPSIGFTWRKLLGMMEGYDFSGYPVVLDSRSNYLIGYLKKSSLKSSFEAAKLEPSFTFDQQLCFGKVDSVGDSKSSKFGESDRIDLSAYMDVNPISVLHTQSIANVAVLFEVLSPSVIFIEKDGNLVGLISKKDLLLASKYYQEDNDLVNPANRHRAVSTERINDSYENIELKPLKLNIE
What is the function of this protein?
Anion/proton exchange transporter involved in iron and copper cation homeostasis.
What are the official names of this protein?
Putative anion/proton exchange transporter C19C7.11.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RL23_PROM9
Sequence: MSKLFDSRLADVIRKPVITEKATNALDLNQYTFEVDHRAAKPQIKAAIEALFSVKVIGVNTMNPPRRTRRVGKFSGKRSQVKKAIVRLAEGDKIQLFPES
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RISB_PSEAE
Sequence: MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVAESEITIIRAPGAFEIPLVTQKVAQQGGFDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSLQFGIPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CBPB2_RAT
Sequence: MKLYGLGVLVAIILYEKHGLAFQSGHVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVNSVKAYLNASRIPFNVLMNNVEDLIQQQTSNDTVSPRASSSYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSYEKYPLYVLKVSGKEHRVKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENTYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSVHMNNRCVGTDLNRNFASKHWCEKGASSFSCSETYCGLYPESEPEVKAVADFLRRNINHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERFIKPTCAEALAAVSKIAWHVIRNS
What is the function of this protein?
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.  Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
What are the official names of this protein?
Carboxypeptidase B2, Carboxypeptidase R, CPR, Carboxypeptidase U, CPU, Thrombin-activable fibrinolysis inhibitor, TAFI.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UNG_HCMVA
Sequence: MALKQWMLANIADNKGSLLTPDEQARVFCLSADWIRFLSLPDHDTVLLRDTVAAVEGARQLEMVYPAPEHVHRWSYLCPPEQVRVVIVGQDPYCDGSASGLAFGTLAGRPPPPSLNNVFRELARTVDGFQRPASGCLDAWARRGVLLLNTVFTVVHGQPGSHRHLGWQTLSNHVIRRLSERREHLVFMLWGADAHTCEYLIDRRRHLVLKSCHPSPRNTTRAFVGNDHFILANAYLDTHYRETMDWRLCG
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RL29_LATSS
Sequence: MKAKDIIELTTAEMLEKEHQYKEELFNLRFQQATGQLENTARLKQVRQNIARIKTVLRQQELNK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: GRP75_CANLF
Sequence: AXEAIFGAVVXIDL
What is the function of this protein?
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis.  Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU.  Regulates erythropoiesis via stabilization of ISC assembly.  May play a role in the control of cell proliferation and cellular aging.
What are the official names of this protein?
Stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus, nucleolus.
Protein: PHS_AZOSB
Sequence: MLNELSTRKCTPCQGGMPALDRSEAERYLSQAPGWSLADNGSRIERHYSFRDYRSALRFVVDLSQLAEDEGHHPDISFGWGHATVSWQTKKIKGLHENDFIMAAKTDQIAGDGNGSA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SRB8_ASPOR
Sequence: MIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVNRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVTQPDKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAILISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPHPTWAVKSEIGQWIRHGIAGHCRDSPRYVYLLSRSTAPANNYRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILENSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFVGLMSQDIIRQVWKHHYHYKNLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRANGLQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSQGYRPCPGILLQTHALDVAASLIDTFPDEARQQCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAVTSASLSEGINCVASHLRLQYRGRAMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA
What is the function of this protein?
Component of the srb8-11 complex.  The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 12, Mediator complex subunit 12.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RB27A_MOUSE
Sequence: MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGAVGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHTSADQLSEEKEKGLCGC
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion.  Plays a role in cytotoxic granule exocytosis in lymphocytes.  Required for both granule maturation and granule docking and priming at the immunologic synapse.
What are the official names of this protein?
Ras-related protein Rab-27A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
Protein: TBL33_ARATH
Sequence: MKPSSPISLTSSSIARKARFSPYLFTLLAFILFVSVLYGEDFMCIFGQLEPNFVLPPSRTPEKNKKSEKLAFAIGKTEESCDVFSGKWVRDEVSRPLYEEWECPYIQPQLTCQEHGRPDKDYQFWRWQPNHCDLPSFNASLMLETLRGKRMMYVGDSLNRGMFVSMICLLHRLIPEDQKSIKTNGSLTVFTAKEYNATIEFYWAPFLLESNSDDAIVHRISDRVVRKGSINKHGRHWKGVDIIIFNTYLWWMTGLKMNILQGSFDDKEKNIVEVSTEDAYRMGMKSMLRWVKNNMDRKKTRVFFTSMSPTHAKGIDWGGEPGQNCYNQTTLIEDPSYWGSDCRKSIMKVIGEVFGRSKTPITLLNITQMSNYRKDAHTSIYKKQWSPLTAEQLENPTSYADCVHWCLPGLQDTWNELLFAKLFYT
What is the function of this protein?
Probable xylan acetyltransferase that plays a role in xylan acetylation and normal deposition of secondary cell walls (PubMed:26745802).  Required for 2-O-monoacetylation, 3-O-monoacetylation and 2,3-O-diacetylation of xylosyl residues in xylan (PubMed:26745802).  Required for the formation of 3-O-acetylated, 2-O-glucoronic acid-substituted xylosyl residues (PubMed:26745802).  May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 33.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: DFRA_ARATH
Sequence: MVSQKETVCVTGASGFIGSWLVMRLLERGYFVRATVRDPGNLKKVQHLLDLPNAKTLLTLWKADLSEEGSYDDAINGCDGVFHVATPMDFESKDPENEVIKPTVNGMLGIMKACVKAKTVRRFVFTSSAGTVNVEEHQKNVYDENDWSDLEFIMSKKMTGWMYFVSKTLAEKAAWDFAEEKGLDFISIIPTLVVGPFITTSMPPSLITALSPITRNEAHYSIIRQGQYVHLDDLCNAHIFLYEQAAAKGRYICSSHDATILTISKFLRPKYPEYNVPSTFEGVDENLKSIEFSSKKLTDMGFNFKYSLEEMFIESIETCRQKGFLPVSLSYQSISEIKTKNENIDVKTGDGLTDGMKPCNKTETGITGERTDAPMLAQQMCA
What is the function of this protein?
Bifunctional enzyme involved in flavonoid metabolism.
What are the official names of this protein?
Dihydroflavonol 4-reductase, DFR, Dihydrokaempferol 4-reductase, Flavanone 4-reductase, FNR, Protein TRANSPARENT TESTA 3.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: COAX_ERYLH
Sequence: MLLAADVGNTNVVFALFEGRDIRARWRIATDPRRTGDEYAVWLLQLLQIEGVQREEITQIIFASVVPRANHNLTVLCEKYFGIAPLVAGEGKAAWPFQADVDQPSSLGADRALNILAAHEKYGGDLIVVDFGTATKLEAIDFNGTYKGGIIAPGINLSLDALVGKTAKLPRIAIRAPETASVIGRNTEDQMLIGVFWAHVAMMEGLIERMRAEIGRPAKVVATGGLAILFDEKTDIFDHVDADLTIEGLAILAEHASKQ
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGXA_ASPOR
Sequence: MKLSGSSALLLLGFGLLGHASPLVHVQGKNCTVKPLGHGQDDVPNILHAVEKCGQTPGGRISLPAPYTYRINQRMTTHLESSTLEVGGMLLFSDDITYWVNNSYRIDFQNQSTAWRITGHDYVVDGGPERGGIDGNGQLWYTWAKGGSNVFGRPMPLHVLNSTRAVLRNIAIRQPQFWAVLVESSSHVELDNFYVNATNSDPNATEDTVWIQNTDGIDTYRSDHVTITNWVYEGGDDAVAFKPNSTNIHVENVTVYGGPGIAFGSLGQYPDRYDIVENITVKNANFQPSSQRAMNSGIYFKSWIGVNFGVPPNGGGNGHGYVRNVTVEDITFKDVQLPIYIDTCLSYLFDQNVTQYCDTSTFRFDDLHFRNISGNGLATPTNYTGRNITFAVSMICSKEAPCTDITFEDVDIKLPESYSGKSVLCENAGVQGLECNS
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Putative galacturan 1,4-alpha-galacturonidase A, Exopolygalacturonase A, Exorhamnogalacturonase A, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDUL_KLEP7
Sequence: MDKQQLASTVNKVLDEMRQRPIPIGISSRHIHLAAADYARLFPAQPIQPKKALLQPGQYAAEQTVTLVGPKGRLNNVRLLGPLRQTSQVEISRTDARILGIAAPLRMSGNLQGTPGIRLISPFAELELSGGTIVAQRHIHMSPLDALILRVSHGDSVAVAIEGSDRRLIFDNVAVRVAPDMRLEMHIDTDEANAAGADAAQAWATLVTKP
What is the function of this protein?
Involved in 1,2-propanediol (1,2-PD) utilization within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
What are the official names of this protein?
Phosphate propanoyltransferase, Phosphate acyltransferase PduL, Phosphotransacylase PduL, PTAC, Propanediol utilization protein PduL.
What is the protein family that this protein belongs to?
Belongs to the PduL family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: FPG_MOOTA
Sequence: MPELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKYLLVHLSGEYCLVVHLRMTGRLVFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLAAKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIKQVLLDQRLVAGIGNIYADEMLFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQVYGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: CYAC3_RAT
Sequence: MASGWFYMSCMVLGSLGSMCILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFFVLKNATRPYSSLPGEAVFANSTGILVVSFGLLVLYILLASSWRRPDPGALTDRQVWLLVSHYRWDKAKKACFAPC
What is the function of this protein?
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome.  Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters.  It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.
What are the official names of this protein?
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3, Cytochrome b ascorbate-dependent protein 3, Cytochrome b561 family member A3, Lysosomal cytochrome b, LCytb.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: TICRR_DANRE
Sequence: MASQNVVFAIDVDYRPEGTQNTTNAYQDHLKQWILRVLLSLGHRYGLEKVRWGYKFFNSRTVKSATLITRGSDFKELQEKVFSDFEEELHVKFTTEGKSPRSQEKSHKLKPSPACCVQNALKEILLDFQWDRPDLTSPTKVTLRPRRSSRSGRNIPLQDCDMLSVDKNVLFVVSECPRSKAELEDYLSMRREDSRHHKDINEQMLPKGLIDMLMQRNVVLHWADSGVFKADHVAKDYTGIETLMERLGLVGGQVVPMLSPCLPLMDQHPKMNSLLALGVDAFPIDSTNSYLHLSKRMQQQLFPPLGASFSWIADGTKRSCNVTLEPVSYRQRSLRAPVDVLLKGVLQSLDILSLSHSAIETWILQCPDAELGQEAFQHLKQLSTGGHAMLAEVSEGDVVCSAVLSVLSSCTAQITVLQPLLAQEGQLLPADLVSLDTTDISGDLPDVVSSVLSVMYDIMEEDDCSDHEKMPLVPDWANQELKQQSSSRSNGMVEGWFPLSDQSGISCHLMESMRLLHAAPEEKEKGEEYSDTQQEITSSLSEFYQSSTAGSSGSLRSKKRGTQCTPVRQKMKTMSRSLQMLNFARLNVKAQKTQGDSGSAGSGKGTEKGGKKSSGDRTKPGLLHFSSEEELLSHLGLTYQKAVENRTMSVPSQVQDLLSVVKSFLKSNTEASLLNLVQKHVLKSCQSIRQHYGNSSDDESKIRECQLQAVLRLELCKQTEQEDEEVVEQRVEDVADMLRNISRSKDAVYLSRFMQEEVLPLYMNSIPKVLADVYHSLGTQLPEALVAVLPSDFFSDESLAKDSVSVSLSSFSATQSNISSVGDHLEELRNRSAKKRRQSMITRHKSMTEAPQALRQIEMPRKSTRLAKPKLCVPIEKTAVEQPPLPKQPVQEVTKVRRNLFNQVTVSPSKKSKMPRSQSVSAVEGIKKRKRSDVDNDDRHTLLTKKVSETPLHKQVSSRLLHRQRTGRKSGESDVCIIEESPIKPAADLRRSPRIKSLTRRHSSVFYSSSQPRSRNLDRVVSSSQLSHSEGKGKFSVSSVRSPVRLLFGATQSPGRLRHTTVSSLEDQASKGLPLRCSSFENQNKTPQKLRSDALASAVGCRTPQSPRTPNRTVGDNGMALRGSPFQSPAAKSIVVETPMKSPLKGILKTPIKKSLLDCVSPNGAWLRSPGCKTPKKCVTWSPSPRKPVPENQVNVPDSPVFAKRHSPRLVTPGKNSSPEEKIVFKTPDKVPQRKSKTSPEIILRRLEIPVNIDPETCKSITRSGKIRTLSLPYKTSKGSDEFLPQSESGSFPFCNSPLKPNIQKTIQSPIPTHRMCTRSGNTPVKESCSPSSNSQGITGTSPSPRKSLSSAVAKSSPSPSFGPSRSGVGNQNNSSISNVEKHTDDDKIIVQNKANDEKAEEASSSDSQQFDCSEFSITTDDESIDISEAAVVKTQLVGGIKMNIAFSRKPSKSDVFEFEGKQTTSTGTPLTRSYGFRQTPDRRQREAEARLGYSSGKPKISTPRTRRTPACGKQSSPQPLTYEVEMEMQASGLPKLKLRRTDSFNAGDLPSSATKGMTSHLVHRNKTNLKAPQIDSPLVQSSRHPGCISPSLCSRATPAKGTPGKGVQTYICQSITPTHHPTSSQSPLASPLTPSPQSRGWPTPENLNSWPRKKRARIETCGNKEQVIKGVPLLEKTGVIEDPELEGIFRIQGVEELKESLSTPISQRKLGLRSSQVMDHQGSPEGMDWTETMAQMCDAKDSTKTEQFAWMGRKVDTPKVKKQVSASGIFALTQSPLLYKKSAVIKEATQFSGSKSELEISPLCQPRRRRTPSRTYSRKKLLD
What is the function of this protein?
Regulator of DNA replication and S/M and G2/M checkpoints.  Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins.  Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC).  Required to prevent mitotic entry after treatment with ionizing radiation.
What are the official names of this protein?
Treslin, TopBP1-interacting checkpoint and replication regulator, TopBP1-interacting, replication-stimulating protein.
What is the protein family that this protein belongs to?
Belongs to the treslin family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: IF1_STRPG
Sequence: MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX8A_THUOB
Sequence: VHGKPATIDHFALIXVSYF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 8A, mitochondrial, Cytochrome c oxidase polypeptide VIII-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIII family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RPOA_CLOB1
Sequence: MLEIEKPKIECVENAEDGSYGKFVIEPLERGYGITLGNALRRILLSSLPGVAADHIKIDSVLHEFSTVQGVKEDVTELILNIKCLALTMNGEGPKTIYIDEVGPKEVTAADIKTDGDVEVINKDLHIATLDENGKMYMEINVNRGRGYVTQNKNKTKDMPIGSIAVDSIYTPVKRVNFSVENTRVGQITDYDKLTIEVWTNGTIRPEEAVSLSAKILIEHFKLFMTLTDHADDMEIMVEKEEDKKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELCERSMDDMMKVRNLGKKSLEEVEQKLEALGLGLRKSED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: STAS1_HUMAN
Sequence: MPRPASESWSPIQSRIPAYKAVSHLRLLPTANSPSGSNQPTNPNRAQHPEGPQSREGATSPVLASLEPPTPTDLPSARARPRVPAESGPGWLHKARRPTRGILRDVLRHRGVPAQPRPAPGAHQLSSPSS
What are the official names of this protein?
Putative uncharacterized protein ST20-AS1, ST20 antisense RNA 1, ST20 antisense gene protein 1.
Protein: H2A_KLULA
Sequence: MSGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRKGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPKKSSKAKASQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.