PharMolix/UniProtQA huggingface dataset:
Protein: AGP1_ASCSU
Sequence: MNKAARAAANFFAPDDDDATSSGEGLTSNDSFSRNFLVSTDLSDEENRKAVEKYRSHIKSMLCCGEGEAIVELGVSIYDDTQKGLSKEELQIAEERHKQLMNQSNISSSHLVTKRCGDLYTSFHLIRDSVDADDFIEVRVAVVGNVDAGKSTLLGVLTHSALDDGRGQARRKLFRHKHEFESGRTSSVGNDILGFSMDGQIVNKPDVHSGNLDWVSICRDSAKVITFIDLAGHEKYLKTTIFGMTGHAPDYTMLMVGSNAGIIGMTKEHLSLALSLSVPVFVVVTKIDMCPDQVLAETLRNLDRLMKSPGVRKLPLPMRSMDDVVQRALHFAGGRLCPIFQVSNVVGTNLDLLKAFLNLIPLRRSLSLDSPAEFQVDDVYWVDGVGTVVSGTCLAGTIALNDTMMIGPNASGEFVPIPIKSIHRKRIACVEDSMWTDSIICIRKFNKKEVRKGMVLVSPLLKPRASLQFDAEVRVLHHPTTIARNYQAMVHVASIRQTATIIQMTKEVLRTGDRDLVTFRFIRNPEYIRVGSRMVFREGRTKAVGTVIKVYPHMPAGATKQNRSKHAKQKDGHHSKQTYASIEKERNASGH
What are the official names of this protein?
GTP-binding protein AGP-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
Protein: PPNP_CLOB8
Sequence: MSEFKNVTAVKKANVYFDGNVTSRTIIFEDGERKTLGIMLPGDYEFGTGDKEAMEILGGSMDVKLPGSDKFVTYKEGDTFMVPANSKFSLIVKEVADYCCSYIKE
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: CCD81_MOUSE
Sequence: MLDRVGPGFQDLCRQVLPTLPTLSQEEVSTIWANVSDFVERQLTMHKGVQISGLGTFTFSRQQLEVGNKKFVLVQRPVFIMAEKLVQTHGLKQNKVFSPGDIPVVPLNFVMISLEGPFNRDTIEGCVKETLLFLSRSISVKQKVEFTFKGIGVLSIRDSKVKMRFYKDFLCSMDGSGILTKALANRPGTMDSVLSSRESYRKRPNSAMAFPRIEHKETENKTPVEVVGEEGGENRPRKIKLKDQSDKEGGAREISSPKKHRERQSISPAKVTSVSLLDKFERSGNGGKITACENLSSPGCQRNDNERPRTSPAPACQDHNKAGQEMCYVCLQRAQRNFALHYGDERRRREIEDERLMQQYQILKDQEAFFKNQVKGMAAREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPEINAFKQEEYSQSLLKQMESKREKEIKQRQNRELMDRLEQVQLTEELAAQRAQYLKEKMEETQHYKRALDAQVKNKPPQLPMFEPDSAEPIFGKNDGEREMEKRKREQSCMKHQMEAAASHKRNTILNQLVDQRRDLQMLQRTQREHMADRAAEMDRVNRLNQCLQEDWDRSLAMKKQRDVEEKAFERASDKLFLLDQCEKYRRCRQCQRRTCNTGESNLWPMNKFLQGSRLLV
What are the official names of this protein?
Coiled-coil domain-containing protein 81.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: PRIA_TREPA
Sequence: MAPWLELVFDVPLDKSFTYRACAAHAGEALVGRRVLAPFGARTLIGFVISESHSSPADCGGAVGTFKEIIRVIDREALFDQTHLACARWMAHFYLCALGQALCAVVPSRKRERTLSSFASCAGVRRTDTYALSGEQRKAIDAITASTGARSFYVHGVTGSGKTEVFLRAAEAVLARGKSVIYLVPEIALTHQVLQEVYVRFGSQAAVLHSALSGSQRLGEWRRIQCMRHCVVIGARSAIFAPLKRLGLVIMDEEHDSSYKSAHVPRYHARQVAMYRCADANCPFVMGSATPSVEAWYAMLRGAVRRLPLTARVAGGAPPRVEVVDVSKEALLLSTRLVDEIRKTKEAGYQSMLFLNRRGFSYSFQCRSCGYTLCCTQCAVPLTWHKRVGAMQCHYCGRQEAPPESCPCCHSFDTRYGGVGTEYIEEAVQALFPEYRIARVDTDALRSGHVQQTMEQFRAGKIDVLLGTQMIAKGFNFPTLRLVGIACADTGLHTPDFRAAERSFALMMQVAGRAGRYVDNGLVIIQTRNPAHPAVVCAQHGDCESFYAQELAQREALCFPPFVRLIRFVFRSKTRRKAKDAAYAAHALLTAQMPLGADVLGPAACVVAQVAGSYRMQILLRAPSFPVVQQVARSFLDEFRAPAGVYVESDVDPVNVL
What is the function of this protein?
Involved in the restart of stalled replication forks.  Recognizes and binds the arrested nascent DNA chain at stalled replication forks.  It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
What are the official names of this protein?
Primosomal protein N', ATP-dependent helicase PriA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PriA subfamily.
Protein: ACR1_ACTEQ
Sequence: MNQVMTIFLVLGVIVYSVESSSTPDGTWVKCRHDCFTKYKSCQMSDSCHDEQSCHQCHVKHTDCVNTGCP
What is the function of this protein?
Toxin that is lethal to crab (PubMed:16183092).  It interacts with divalent metal ions (zinc and nickel) suggesting it may function as a metal ion chelator to regulate metal ion levels or as a metal ion transporter, or that its function is modulated by metal ions.  Is not active against any of the voltage-gated potassium and sodium channels tested (PubMed:33387653).  In addition, it does not show activity in bacterial and fungal growth inhibitory assays as well as in hemolytic assays (PubMed:33387653).
What are the official names of this protein?
U-actitoxin-Aeq5a, U-AITX-Aeq5a, Acrorhagin I, Acrorhagin-1.
What is the protein family that this protein belongs to?
Belongs to the Acrorhagin I family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: PEPT_STRTD
Sequence: MAYDLLLERFLRYAKINTRSDENATRTPTTQSQVDFALNILKPELEELGLSNIHYLESNGYLVATLPANDDRLTRKIGFISHMDTADFNAEGVSPQVIESYDGGIIPLGTSGYNLDPADFPNLQNYIGQTLITTDGTTLLGADDKSGIAEIMTALAHLKANPEIKHCEIRVGFGPDEEIGIGADKFDVDDFDVDFAYTVDGGPLGELQYETFSAAGAELIFHGRNVHPGTAKGQMVNALQLAIDFHNQLPAEDRPELTDGYQGFNHLQTMTGTVEEANSSYIIRDFETESFENRKATFQEIADKMNQAYGQTRVDLVIKDQYYNMRQVIEKDMMPVELAKEVMEDLGIVPVIEPIRGGTDGSKISFKGIPTPNIFAGGENMHGRYEFVSLQTMEKAVDVILGIISKP
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P4R3A_XENLA
Sequence: MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDPIDESEEERFEEMPETSNLIDLPTCELGKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQTCENLDNTEGLHHLYEIIRGILFLNKAALFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDVILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDSDPELGGAVQLMGLLRTLIDPENMLATANKTEKSEFLNFFYNHCMHVLTAPLLANTSEDKLEKDAVFGSIKTSTVCPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLILMNSKHTFLALCALRFMRRIIGLKDEFYNRYIIKGNLFDPVINALLDNGTRYNLLNSAIIELFEFIRVEDIKSLTSHIVENFYKALEPIEYVQTFKGLKTRYEQEKDRQSQKLSSVPSILRSNRFRRDARALEDDEELWFNEDDEEEGEAVVPPVEKTKPEDDFPEGYEKFLETKKAKELEDKENLPKRTSVGAFKFTFSHSVSAANGANSTNSKSVAAHTPPATSNGSSSKNTSLTTTVASTKGSLIGLVDYPDDEDEEEEEDASPRKRPRLGS
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 3-A, SMEK homolog 2-A.
What is the protein family that this protein belongs to?
Belongs to the SMEK family.
Protein: GSA_MYCLB
Sequence: MGSTDQATAPAGPAVSISAKLFEDACAVIPGGVNSPVRAFSAVGGTPLFITEARGCWLTDADGRRYVDLVCSWGPMILGHAHPAVVDAVATVAASGLSFGAPTPAETQLAAEIIGRMAPVERIRLVNSGTEATMSAVRLARGFTGRTKIIKFSGCYHGHVDALLADAGSGVATLSLPSSPGVTGAAAADTIVLPYNDIEAVRQTFARLGDQIAAVITEASPGNMGVVPPAPGYNAALRAITAEHGALLIIDEVMTGFRVSRSGWYGLDPVAADLFIFGKVMSGGMPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAGLATLRAAADAVYATLDRNADRLVAMLSEALTDAGVPHQIPRAGNMFSVFFSEAPVTDFASACNSQVWRYPAFFHALLDAGVYPPCSTFEAWFVSAALDDAAFGRIVDALPGAAAAAVAARHRES
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_METB6
Sequence: MSERVISPEPVPDDADEITLRPSTLEAFVGQEPAKNALRIAIAAARKRGEPIDHILFAGPPGLGKTTLAHIIAREMGAAIRTTTGPVLEKTGDMAAIATALQNGDVLFIDEIHRMNPVVEEILYPAMEDFFIDVMIGEGPSARSIKLTLERFTLIGATTRQGLLSSPFRDRFGLLIRLNLYSPEDLEKIVTRSAEILRIPITPKGAAVIASRSRGTPRIANRLLRRVRDYAVVEGDGTITAEIAGAGLALLQIDELGLDDIDRRILSVIAGDFGGGPVGAKTIAISVGEEVRTIEEVYEPYLIQIGFVKRTPQGRETTPAALAHLKLNHSQKTLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CD19_HUMAN
Sequence: MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR
What is the function of this protein?
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes.  Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701).  Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701).  Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126).  Required for normal differentiation of B-1 cells (By similarity).  Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518).  Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701).
What are the official names of this protein?
B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Protein: CDTA_AGGAC
Sequence: MKKFLPGLLLMGLVACSSNQRMSDYSQPESQSDLAPKSSTTQFQPQPLLSKASSMPLNLLSSSKNGQVSPSEPSNFMTLMGQNGALLTVWALAKRNWLWAYPNIYSQDFGNIRNWKIEPGKHREYFRFVNQSLGTCIEAYGNGLIHDTCSLDKLAQEFELLPTDSGAVVIKSVSQGRCVTYNPVSPTYYSTVTLSTCDGATEPLRDQTWYLAPPVLEATAVN
What is the function of this protein?
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.
What are the official names of this protein?
Cytolethal distending toxin subunit A, CDT A.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: DNLJ_BIFLO
Sequence: MSTNEQLAWDFDDGDVAEVRPDTGIARFAPGSEQWIAALQPTDDDAIRLDRFDVNTMTAEAAARLWARVAAWVESDQIAYYIDDSPVSSDAAYDARMRCLERLEAAFPSLDNPQSPTHRVGGSFSNDFASVRHPSRMMSLDDVFSIEELKDWYDSVIRDLDWPESKPLPMSCEVKIDGLALNLIYRNGVLEQGLTRGDGVTGEDITLNVRTIGSIPANLGGPKEDVPDFVEIRGEVFMRWDDFHTLNNEQEDAGRAPFANPRNAAAGSLRQKDPRITATRRLSFYAHGLGQLTWGPDHPRGTHDVVADQSQAYDLYTKWGVPVSPHNRAVTSFQEILDMIEYYGEHRGDIEHALDGIVVKVDDLGLQRTLGATSRAPRWAIAYKYPPEEVNTELLNITVQVGRTGRVTPVAVLKPVYVAGSTVARTTLHNGFEVKRKGILIGDTVVVRKAGDVIPELVGPVLERRKGREDQLREFVMPEFCPSCGAKLSPAKEGDKDIRCPNVESCPAQLTERVISLASRKAFDIEHLGEQSAIALTNPEENRPDSVATYAPNITEVLVAPGEEPDPYEPVEGLELPAAQKPVLSNESGLFNLTAADLRDVRVWREAAIVEVHETVGANGKKKKVRKRVGGSGLWHQVPAFWTAPTPAKKLTAKQLAERAQGEAAIESAETQGDTASETTGAPTGAEAPLGTMPGFAAASYPEYDVPADAVIVRVDHKTTRTGVTDVPVIIRPGENTRKMFDEMDKARHADLWRVLVALSIRRLGPPTARLIASAMGSLAAIENATIEDLTAIDGVGPEIAESVVNWFAATREPGDWRGATLRAWQAAGVGVDEAETSSLPQTLAGKTVVVTGSLEGYSRDSAKEAIIERGGKAAGSVSKKTDYVVIGANAGSKAAKAEELGIPMLSETQFAQLLATGTI
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PUF60_MOUSE
Sequence: MATATIALQVNGQQGGGSEPAAAAAAAAAAVVAAGDKWKPPQGTESIKMENGQSTGTKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLATPGLVSPALTLAQPLGALPQAVMAAQAPGVITGVTPARPPIPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSMASETHKAIQALNGRWFGGRKVVAEVYDQERFDNSDLSA
What is the function of this protein?
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation.  In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor.  Acts as a transcriptional repressor through the core-TFIIH basal transcription factor.  Represses FUBP1-induced transcriptional activation but not basal transcription.  Decreases ERCC3 helicase activity.  Is also involved in pre-mRNA splicing.  Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2.  Involved in apoptosis induction when overexpressed in HeLa cells.  Modulates alternative splicing of several mRNAs.  Binds to relaxed DNA of active promoter regions.  Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2.  Binds to Y5 RNA in association with RO60.  Binds to poly(U) RNA (By similarity).
What are the official names of this protein?
Poly(U)-binding-splicing factor PUF60, 60 kDa poly(U)-binding-splicing factor.
What is the protein family that this protein belongs to?
Belongs to the RRM half pint family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes partially with RO60.
Protein: ZRAP_ECO57
Sequence: MKRNTKIALVMMALSAMAMGSTSAFAHGGHGMWQQNAAPLTSEQQTAWQKIHNDFYAQSSALQQQLVTKRYEYNALLAANPPDSSKINAVAKEMENLRQSLDELRVKRDIAMAEAGIPRGAGMGMGYGGCGGGGHMGMGHW
What is the function of this protein?
Binds zinc.  Could be an important component of the zinc-balancing mechanism (By similarity).
What are the official names of this protein?
Zinc resistance-associated protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: HSLO_VIBCH
Sequence: MANNMLHRYLFKDLSVRGELVQLDDTYQQMISSQEYPAAVQHLIGELLVATSLLTATLKFEGSITLQLQGNGPVSLVVINGDNNQQVRGVARWKGDIADDASLHDMLGKGHLVITIEPKQGERYQGVVGLEGDTLAQVLEGYFERSEQLKTRLWIRVGKHDGKACAAGMLLQIVPDGKGSAEDFEHLEQLTNTIKDEELFALPAEELLYRLYNQETVQLFTPQQISFRCGCSRERSAAAIVTVAREEINDILAQDGAVALHCDYCGTTYSFDSAQVAELYAPSSANGSTLH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPP2_ENTH1
Sequence: MFAFICLLAIASAIDFNTWASKNNKHFTAIEKLRRRAIFNMNAKFVDSFNKIGSFKLSVDGPFAAMTNEEYRTLLKSKRTTEENGQVKYLNIQAPESVDWRKEGKVTPIRDQAQCGSCYTFGSLAALEGRLLIEKGGDANTLDLSEEHMVQCTRDNGNNGCNGGLGSNVYDYIIEHGVAKESDYPYTGSDSTCKTNVKSFAKITGYTKVPRNNEAELKAALSQGLVDVSIDASSAKFQLYKSGAYTDTKCKNNYFALNHEVCAVGYGVVDGKECWIVRNSWGTGWGDKGYINMVIEGNTCGVATDPLYPTGVQYL
What is the function of this protein?
Cysteine protease which degrades matrix proteins such as collagen, laminin and fibronectin and thus is involved in the destruction of human tissue (PubMed:2898937).  Can abolish adhesion (PubMed:2898937).  May play an important role in pathogenicity (PubMed:2898937).
What are the official names of this protein?
Cysteine proteinase 2, EhCP2, Histolysain, Histolysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: FTHS_STRU0
Sequence: MKSDIEIAQSIALKPITEIVEKVGIAFDDIELYGKYKAKLSFDKINEVKSNPVGKLILVTAINPTPAGEGKSTMSIGLADALNKIGKKTMIALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNELGIDQRRIIWKRVLDLNDRALRHVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKERLANIVVAYDYNRKPVYVRDLKVEGALTLILRDAIKPNLVQTIYGTPALVHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLDIKVPNLPTSPDAVVVVATLRALKMHGGVAKTDLNQENVEAVRAGFANLERHVNNMRQYGVPVVVAINEFVADTEAEIAVLKELCQSIDVPVELASVWANGAEGGVALAETVVKVIEQEKANYQRLYNDQDSVEEKVRKIVKNIYGGDAVQFSAKAKNQLKQFAEFGWDKLPVCMAKTQYSFSDNPNLLGAPSGFDITIREFVPKTGAGFIVALTGDVMTMPGLPKHPAALNMDVSEEGTAIGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ERR1_RAT
Sequence: MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
What is the function of this protein?
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'.  Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter.  Binds to the C1 region of the lactoferrin gene promoter.  Requires dimerization and the coactivator, PGC-1A, for full activity.  The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.  Induces the expression of PERM1 in the skeletal muscle.
What are the official names of this protein?
Steroid hormone receptor ERR1, Estrogen-related receptor alpha, ERR-alpha, Nuclear receptor subfamily 3 group B member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Co-localizes to the cytoplasm only in presence of MAPK15.
Protein: KTHY_SULNB
Sequence: MYILFEGIDTCGKSTQMELLTQKHPGIITTHEPGGTAFGQQAREILLSDSLRSKRAELLLFLADRAEHYEEVVEPNHDKIVVSDRGFVSGIGYALANGDFDFDELVALNRFALKDHFPDRIILFMTDMETLKQRISEKELDGIELRGLEYLLRVQEHMKESILKLGIPHLFIDATDSIENIHQSILTYLKV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: Y367_PYRAB
Sequence: MEREEFVEFVERILRRIGFKTLKLNFRGGCFNLVATRSLLLLFIKALANIDKFSEEQAEDLKRLAKLFKASPILVGLRTKNYEMEDGIVYERFGIYAVTPGTLYSMFAEGEPPLIMAERGGFYVRIDGKRLKDLREKHGYSLSELANILGVSRKSLQRYEKGDSMVTLEVALRLEEVFDEALVKPINVLKAKFDEISLSSKPETTLEREVFERLERIGMEVVKVKTAPFNAITTEEEDNIELLTGIDEKKTEKTLRRAELVSQMAEIVGSEGMFVLKRARIEVVNKVPILPTRVLEEVRDADELLEIINELKEAKS
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein PYRAB03670.
Protein: Y5631_BACCX
Sequence: MLEKQNSEENIELLRAMRYCYNKSKIFYAVRISISILIPILSISIYLFNRGSTGTSNTGVWFSVIGSIWLLIAYQIEKLEGGYIEKGAKIQEKFDINLFNIRWNNVLVGNQISPEDIRDFSSKFKGDEEKLKNWYGGLSSKHFYVNVILAQRSNLMWAISLKRNFSILLFTVSVLYLFLTIAFGFFVNMSMQEYIIKILLPSMSILIYGFKTSDELKKQSNKLEALGNSIISKFDTGNLSEINASACREYQDAIFVYNRIRSILIPEWLYWLRQQKDDEKMIQINIRLTKKSNLF
What is the function of this protein?
Protects B. subtilis against phage infection.  When IK1_05630 and IK1_05631 are introduced in B. subtilis BEST7003 there is 1000-fold protection against phage SBSphiC.  Both genes are required for protection.  Activation leads to bacterial cell lysis and death, which occurs before the phage has finished its replication cycle, thus protecting non-infected bacteria by aborting the phage infection and preventing its propagation.
What are the official names of this protein?
Probable CBASS effector molecule IK1_05631.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBM_PLALA
Sequence: MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RL29_SPICI
Sequence: MNDLTKKSVEELKKLEEESRAELFALRFQSAMGNLEKPHRIGELKNQIARILTILSARKNSGENTAINVKVNLNETYAKIEKESQAFAKQRKAKIEQMMAEQQAAEGKMANLMDLPVNDAMDLTEEQAVVSTPTGETNGLDEQKAPVAAKKPAAAKDFPKQKDVVEEKTATGKPAAPSAKKAPVAKKDVAQETKTDKDAALKALIKEKAAAKKPAAKSKTSTPSGKTTVTVKSVTSAKADIEVPKETSKPVPTKTVKKAAELNAKEKLVAIKSSVAMGGTAKEPGSGVKIDLELKAKDPNAKEYTYGTNWKENRDKILTASKTTKKADDKTTKKGTGKK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SPEE_VIBVU
Sequence: MSINPIVLLFALLCTLLSPFSIGQSTIIHEQKSLYQDIVVFEHQDFRCLSFTAKKGERVQTCEYQDPQDKRIYFPYVRMTLAGLLFNPKPERILIIGLGGGSVPSALAELYPESHMDIVEIDPVVSQIAERYFYFQPSHNTRVHTGDARVYIKRAGLKGQKYDFILLDAFNGEYIPEHLMTREFLMETKQLLSSSGVLVANTFSTSKLYDHESATYRSVFGEFYNFKIPQESGNRVILSMLTSLPNQQALQQQAEALASALQPFAIEIENYPSLMTLEADWDEQARLLTDQFSPANLLK
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.