PharMolix/UniProtQA huggingface dataset:
Protein: TRAG4_ECOLX
Sequence: MKNRNNAVGPQIRAKKPKASKTVPILAGLSLGAGLQTATQYFAHSFQYQAGLGWNINHVYTPWSILQWAGKWYGQYPDDFMRAASMGMVVSTVGLLGTAVTQMVKANTGKANDYLHGSARWADKKDIQAAGLLPRPRTVVELVSGKHPPTSSGVYVGGWQDKDGKFHYLRHNGPEHVLTYAPTRSGKGVGLVVPTLLSWAHSAVITDLKGELWALTAGWRKKHARNKVVRFEPASAQGSACWNPLDEIRLGTEYEVGDVQNLATLIVDPDGKGLESHWQKTSQALLVGVILHALYKAKNEGTPATLPSVDGMLADPNRDVGELWMEMTTYGHVDGQNHPAVGSAARDMMDRPEEESGSVLSTAKSYLALYRDPVVARNVSKSDFRIKQLMHHDDPVSLFIVTQPNDKARLRPLVRVMVNMIVRLLADKMDFENGRPVAHYKHRLLMMLDEFPSLGKLEILQESLAFVAGYGIKCYLICQDINQLKSRETGYGHDESITSNCHVQNAYPPNRVETAEHLSKLTGTTTIVKEQITTSGRRTSALLGNVSRTFQEVQRPLLTPDECLRMPGPKKSADGSIEEAGDMVVYVAGYPAIYGKQPLYFKDPIFQARAAVPAPKVSDKLIQTATVEEGEGITI
What is the function of this protein?
Required for conjugative transfer of plasmid RP4.  Binds tightly and specifically to the relaxase TraI.  Can also bind to DNA without sequence specificity.  May form a pore-like structure that could serve as a channel for DNA transfer.
What are the official names of this protein?
Conjugal transfer protein TraG.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL3_ROSCS
Sequence: MIEGLLGRKIGMTQVFDPTGQVIPVTIIEVGPCVVTQIRTKERDGYEAVQIGYQEVRAKSLTKPEQGHLRGAGKLLRHLREFRTDNIADHKVGDVLTVEMFAPGQRVDVIGTSKGRGFQGVVKRHGFGGGPRTHGQSDRLRAPGSIGAGTDPGHLWKNTRMAGRMGNQRVTVQNLTVVDVVPERNLLLVRGSVPGANNGLVMVRRAIKGS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ZSWM2_HUMAN
Sequence: MLRRGYKASERRRHLSERLSWHQDQALSSSIYLLREMGPTGFLLREEEPEYMDFRVFLGNPHVCNCSTFPKGGELCKHICWVLLKKFKLPRNHESALQLGLGEREISDLLRGIHRVQTPQPGTNDENEHVEEDGYIKQKEIDSEDICSICQELLLEKKLPVTFCRFGCGNSIHIKCMKILANYQSTSNTSMLKCPLCRKEFAPLKLILEEFKNSSKLVAAAEKERLDKHLGIPCNNCKQFPIEGKCYKCTECIEYHLCQECFDSCCHLSHTFTFREKRNQKWRSLEKRADEVVKYIDTKNEIEEKMSHFQEKQGQVYTPKHIVRSLPLQLITKNSKLLAPGYQCLLCLKAFHLGQHTRLLPCTHKFHRKCIDNWLFHKCNSCPIDGQVIYNPLTWKNSAVNGQAHQSVSNRDIIHLSKQKEPDLFIPGTGLVLKQNRLGILPSIPQCNFDELNTPQSPKDAYENTTIDNLCSIKLDNSNSKKLTYDYKISQHFPRYLQDLPTVSFGKIPSQTLLPPIVHKNIVCPTAMESPCISGKFHTSLSRMTKGCKCNNHNLKKTPATKIREDNKRSTLLPEDFNLIVNWSTAKLSLSKRYSNCMGEITRKCSHLSRQPVSHSVNTKSTELSLIIEGVQL
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis.  Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
What are the official names of this protein?
E3 ubiquitin-protein ligase ZSWIM2, MEKK1-related protein X, MEX, RING-type E3 ubiquitin transferase ZSWIM2, ZZ-type zinc finger-containing protein 2, Zinc finger SWIM domain-containing protein 2.
Protein: RM49_YEAST
Sequence: MSKVAQQLKFLNKISATTRLPQILVDPKKYSGLRLTFQTKNHNGHMGARVFWHNYLPTLQFYNPRMKFDVIRIKNEDKQKSVPCKLEILSHEGSVVETIDMRNKMHEDIMKDLLDKIEHVPLPENEIIRVGPQESII
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543).  mL61 is not essential in cells grown at 30 degree Celsius but is required for mitochondrial translation in cells grown at 18 degree Celsius.
What are the official names of this protein?
54S ribosomal protein MRP49, mitochondrial, Mitochondrial large ribosomal subunit protein mL61.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL61 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: PDXH_ALBFT
Sequence: MTSIAHLRKSYERAELSEDASHADPLQQFEKWLKEAISAEIPEPNAMTVATVASNLRPSTRVVLIKGYDERGITWFTNYDSRKGQELAGNPYAALQFHWVELERVVRIEGIVEKVSEEESDSYFHSRPLDSRIGAWASPQSQVISGRSVLVANAAKYGAKFLLNPPRPPHWGGYRLKPDHWQFWQGRKSRLHDRLRYTLIEPASTLPDAKPVWIRERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: SYR_CARHZ
Sequence: MEYLLQRITGEIAGSLRRAAVKAGYLDAEDELAFELEKPKEKAHGDLATNLAMLLTKKARKNPREIAATLLEYLEIPAVVERVEIAGPGFINFYFKKDWVVAVIPEILSFGEKYGRLAIGAGKRVQVEFVSANPTGLLHMGNGRGAALGDILANILTEAGYEVSREYYINDAGNQIENFNKSVEARYLELLGYKVEFPEEGYHGEDIIDTARNIVARFGDRFIHLPEKERQEALGKIALEEKLQSIKKSLENFGVKYDVWFSERSLHESGEVEKTVKLLLERGYLYEKDGALWFAASKLGEEKDEVLVRKNGVPTYYAADIAYHKNKFDRGFDLVINIWGADHHGHVSRMKTALKALGYDPERLIVILMQLVRLFQGGELVRMSKRTGQYITLDELVEEVGVDAARYFFVMRSHDAHLDFDLDLAKEKSNENPVYYIQYAHARIMSLYRQCNEQGVTLPPVEDVDLAILSSEAELNLLRHLAEFPVEIEKCATALAPHHLARYLHELAGYFHTFYNSCRVLGVEENLSKARLLLVEATRIVLRKGLKMLGVSAPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_BACAA
Sequence: MAKKLEITLTRSVIGRPQDQRATVEALGLKKLNSTVVKEETPAILGMINKVSHLVTVKEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL32_AZOC5
Sequence: MAVPKRKTSPSRRGMRRSADALKQPTYVEDKDSGELRRPHHLDLKTGMYRGRQILKPKTAEV
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: MAP4_RAT
Sequence: MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKSGNSESKRKPCVDTSQVEDIPSSKPTLLANGDHGVEGNNTTGSPTDFLVENVDYEDYQNSQSWPEDASFCFQPQQVLDTNQADPFNVHHDDGLADLLFVSSGPTNASAFIEENNPLEDSYGVLPCDSFAPTAVVSQEWSVGAPDSPHSEPCVSPEVTIETAQPATELSKAVDLESVKEQLPAKALEMMAGQTTDAVPSKESEGSPDTDAAPGPDTDVTLTKDIEESSSPDVISANVTQPFTESDMFLTQEMELLIGTEAAQVKDTMSSVEPDISSAKNTAPPTEEETVPGKDMTFPKEAETALPIEMDLAPPEDVALPKETELELAPAAGTAPLSETEVALAKDEEPSTGIPAAQEMLLSSETEVVLPSDSIMTLTKEVTVPLEAAGPLVSDMTAILETEMTLGGGTATPTETKLGKVKDMAPLPESEVALGKDVVTLPETKVTEFNNVTPLSEEEVASIKDVSPSPETETAKNADLHSGTELTLDNSMTPPSDPALPLETKVATVQIKDKETVQTQEELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKSTLPVDEGSPLEKLEQKETSGSQPPELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPLATTQPAKTSTSKAKIQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDLKPKPITETKVAEKRTSPSKPSSAPALRPGPKTTPTISKATSPSTLVSTGSSSRSPSTTLPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPPAGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENMKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGTVKTEGGGSEAPPCPGPPAGEEPAIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI
What is the function of this protein?
Non-neuronal microtubule-associated protein.  Promotes microtubule assembly (By similarity).
What are the official names of this protein?
Microtubule-associated protein 4, MAP-4.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation.
Protein: GERPF_BACCE
Sequence: MPSVVGNLVVQNSNGSFNLGDFYNVSPKENTKAYNGSGASNVGFVVNTFNGVSATNTFDSDVADQDQIGTA
What is the function of this protein?
Required for the formation of functionally normal spores.  Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor.
What are the official names of this protein?
Probable spore germination protein GerPF.
What is the protein family that this protein belongs to?
Belongs to the GerPA/GerPF family.
Protein: HTPX1_SULTO
Sequence: MEIGTSLKINMIIALFLTIVSEGIFSLVIINFLKFPVIFSIIFLLILWLIQWLISPYLVERNSVEVTRDDPSYGWVYELVENVARRAGIKTPRVFLVDEPYPNAFAYGNYVTGKRIGITIPLLQILTTEELESVIGHELGHIKHNDVEIGLAIGLIPSILGFISNILLTVGWATLIFAVDEFDILVGLTMLAIGGVLFVITFFLQLFVLWFNRLRESFADYFSYELFRERAWNLAKALAKIEIYMQNIRLDPFRGIIVTIPPTKVKESDPDLLIEDLLREKTNIFSDILSTHPHPAKRIKMIYKLTKPMIF
What are the official names of this protein?
Protease HtpX homolog 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DXS_PSEAE
Sequence: MPKTLHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTGGHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGTLRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSVAVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYAKGMLVPGTLFEELGWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPIGYHAITKLEAPGSAPKKTGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSERYPERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDVAVQHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDELRKLLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVALLVFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIEENAVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLDAAGIEKAVRQRLDRQ
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: TIF4A_ARATH
Sequence: MDVGVSPAKSILAKPLKLLTEEDISQLTREDCRKFLKDKGMRRPSWNKSQAIQQVLSLKALYEPGDDSGAGIFRKILVSQPVNPPRVTTTLIEPSNELEACGRVSYPEDNGACHRMDSPRSAEFSGGSGHFVSEKDGHKTTISPRSPAETSELVGQMTIFYSGKVNVYDGIPPEKARSIMHFAANPIDLPENGIFASSRMISKLISKEKMMELPQKGLEKANSSRDSGMEGQANRKVSLQRYREKRKDRKFSKAKKCPGVASSSLEMFLNCQPRMKAAYSQNLGCTGSPLHSQSPESQTKSPNLSVDLNSEGI
What is the function of this protein?
Regulates the arrest of dispersed meristematic cells during lamina development.
What are the official names of this protein?
Protein TIFY 4A, Protein PEAPOD 1.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABF1_HYPJE
Sequence: MLSNARIIAAGCIAAGSLVAAGPCDIYSSGGTPCVAAHSTTRALFSAYTGPLYQVKRGSDGATTAISPLSSGVANAAAQDAFCAGTTCLITIIYDQSGRGNHLTQAPPGGFSGPESNGYDNLASAIGAPVTLNGQKAYGVFVSPGTGYRNNAASGTAKGDAAEGMYAVLDGTHYNGACCFDYGNAETNSRDTGNGHMEAIYFGDSTVWGTGSGKGPWIMADLENGLFSGSSPGNNAGDPSISYRFVTAAIKGQPNQWAIRGGNAASGSLSTFYSGARPQVSGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDATENSVQANIVAARYAVAPLTSGPALTVGSSISLRATTACCTTRYIAHSGSTVNTQVVSSSSATALKQQASWTVRAGLANNACFSFESRDTSGSYIRHSNFGLVLNANDGSKLFAEDATFCTQAGINGQGSSIRSWSYPTRYFRHYNNTLYIASNGGVHVFDATAAFNDDVSFVVSGGFA
What are the official names of this protein?
Alpha-L-arabinofuranosidase, Arabinosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 54 family.
Protein: TRMB_YEAS1
Sequence: MKAKPLSQDPGSKRYAYRINKEENRKELKHVKINESSLVQEGQKIDLPKKRYYRQRAHSNPFSDHQLEYPVSPQDMDWSKLYPYYKNAENGQMTKKVTIADIGCGFGGLMIDLSPAFPEDLILGMEIRVQVTNYVEDRIIALRNNTASKHGFQNINVLRGNAMKFLPNFFEKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLKEGGVVYTITDVKDLHEWMVKHLEEHPLFERLSKEWEENDECVKIMRNATEEGKKVERKKGDKFVACFTRLPTPAIL
What is the function of this protein?
Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay.  Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1149_STRZT
Sequence: MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLTGDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SPT_1149.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MAMB7_DENPO
Sequence: RPYACELIVAAGPCMFFISAFYYSKGANKCYPFTYSGCRGNANRFKTIEECRRTCVV
What is the function of this protein?
The mixture of mambaquaretin-7 and mambaquaretin-8 interacts with vasopressin V2 receptor (V2R/AVPR2), probably in a selective manner (PubMed:35122240).  This mixture inhibits vasopressin binding human V2R in the nanomolar range (Ki=3. 14 nM), and also potently inhibits vasopressin-induced cAMP production (IC(50)=58 nM) (PubMed:35122240).  In vivo, intraperitoneal injection of this protein into rats increases diuresis, without any loss of electrolytes (By similarity).
What are the official names of this protein?
Mambaquaretin-7, MQ7, Kunitz-type serine protease inhibitor homolog dendrotoxin B, DTX-B, Mambaquaretin-8, MQ8, Protein B, Upsilon-Dp2b, Upsilon-Dp2c, Venom basic protease inhibitor B.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
Protein: CNIH4_HUMAN
Sequence: MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND
What is the function of this protein?
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).
What are the official names of this protein?
Protein cornichon homolog 4, CNIH-4, Cornichon family AMPA receptor auxiliary protein 4.
What is the protein family that this protein belongs to?
Belongs to the cornichon family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.
Protein: LEU1_RHOPB
Sequence: MTATTPSDKDRVIIFDTTLRDGEQCPGATMTFEEKLEVASLLDAMGVDVIEAGFPIASDGDFAAVHEIAKRAKNAVICGLSRAGAKDIDRCAEAIRPAKQGRIHTFLSTSPVHMKYKLQMDAEQVYQLVISAVTRARNHTDNVEWSSEDGTRTEFDFLCKCVEAAIKAGATTINIPDTVGYSVPEEYFDLFKRVRENVPNSDKAIFSVHCHDDLGMAVANSLAGIRGGARQIECTVNGIGERAGNTALEEVVMAMRVRNDKLPFWNKIDTTMLTRASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAETYEIMRPESVGVKQTSLVMGKHSGRHAFVHKLEEMGYKLGQNQLEDAFVRFKALADRKKEIYDEDIEALVDQEIAQSHDRIKLLSLTVIAGTHGPQRATMKLDVEGQTRIEEAEGNGPVDAVFNCIKALVPHVAKLELYQVHAVTQGTDAQAEVSVRLAHEGRSMTARAADPDTLVASAKAYLSALNKIVMKRERDLPVPEAAAS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RNC_STRTD
Sequence: MNQLEQKLEQDFGIVFSQKDLLETAFTHTSYANEHRLLNISHNERLEFLGDAALQLVISVYLYNRYPNKPEGEMSKMRSTIVREESLAGFTKACGFEQYIRLGKGEEKSGGRERATILGDLWEAFLGALYLDQGLPAVEKFLNQVMIPQVEKGNFDRVIDYKTALQERLQVNGKVDITYTVIDESGPAHAKEFTMQVAVDGKELSTGFGKSKKLAEQAAAKSALEQLGN
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In this organism endogenous ribonuclease 3 and Cas9 are required for correct coprocessing of pre-crRNA and the trans-encoded small RNA (tracrRNA).  Cas9, crRNA and tracrRNA are required for cleavage of invading DNA (Probable).  Complements pre-crRNA and tracRNA coprocessing defects in an rnc deletion in S. pyogenes strain 370 (PubMed:24270795).
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_BRUA1
Sequence: MRAGQPKITGAKITGAIIAGGQSSRMQAGGVSGDKFLQPLGSAPVIAHVIARLQPQVDTLFINSKGDLSRFAAFGLPAVKDIAMNHGGPLVGLLTCLAHASPCRLLLTSAADTPFLPCDLASNLIRKQAETGARIILACSNERVHPIVGLWHTDLVPDLEKWLQHAEKASIFWFAKHIGFEVVNIPLAHAPRLAESYDPFFNINLPDDLLKAREINEALQA
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_STAAT
Sequence: MTKPIVAIVGRPNVGKSTIFNRIVGERVSIVEDTPGVTRDRIYSSGEWLTHDFNIIDTGGIEIGDAPFQTQIRAQAEIAIDEAYVIIFMVNVREGLTQSDEMVAQILYKSKKPVVLAVNKVDNMEMRTDVYDFYSLGFGEPYPISGSHGLGLGDLLDAVVSHFGEEEEDPYDEDTIRLSIIGRPNVGKSSLVNAILGEDRVIVSNVAGTTRDAIDTEYSYDGQDYVLIDTAGMRKKGKVYESTEKYSVLRALKAIERSNVVLVVIDAEQGIIEQDKRVAGYAHEQGKAVVIVVNKWDTVEKDSKTMKKFEDEVRKEFQFLDYAQIAFVSAKERTRLRTLFPYINEASENHKKRVQSSTLNEVVTGAISMNPTPTDKGRRLNVFYATQVAIEPPTFVVFVNDVELMHFSYKRYLENQIRAAFGFEGTPIHIIARKRN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PURL_RHIE6
Sequence: MTIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLMVLQPEKEEQAKAIFVKWGLDFAIVGKTTDDLRFRVVHQGEEVANLPIKDLGDQAPEYDRPWRESGKPAPLPANLVAAPKNYGQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHKSKALAFSSDVTPRYVEADPFEGGKQAVAECWRNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDWSKMARIGSANDGDKVIMIGLDGSHLGQSVYLRDVLDSREGPAPEVDLFAERRNGDFVRSVIRNDQATACHDISSGGLAVALAEMAMASGKGLTIDLGECKGAPHALLFGEDQARYVLTVPADVADFVCVNAEGAGVPFRRLGTVGGDALVVDDLITLPIQQLRDTHESWFPDFMEGRGELAAE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACE1_CAEBR
Sequence: MRYSLLFFIFLPCVITAVDLIHLHDGSPLFGEEVLSQTGKPLTRFLGIPFAEPPIGNLRFRKPKPKQPWRIPFNATTPPNSCIQSEDTYFGDFYGSTMWNPNTKLSEDCLYLNVYVPGKVDPNKKLAVMIWVYGGGFWSGTSTLDVYDGRILTVEENVILVAMNYRVSIFGFLYMNRSEAPGNMGMWDQLLAMKWVHKNIDLFGGDTSRITLFGESAGAASVSIHMLSQKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLISPDYDRILDCFQRADADALRENEWAPVREFGDFPWVPVVDGDFLLENAQTSLKQGNFKKTQLLAGSNRDESIYFLTYQLPDIFPVADFFSKSEFIKDRQTWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPISAQNWLNAMDKMLGDYHFTCSVNEMALAHTKHGGDTFYYYFTHRATQQTWPEWMGVLHGYEINFIFGEPFNQKRFNYTDEERELSNRFMRYWANFAKTGDPNKNEDGSFTQDIWPKYNSVSMEYMNMTVESSYPGQNRIGHGPRRKECAFWKAYLPNLMAAVADVGDPYLVWKQQMDKWQNEYITDWQYHFEQYKRYQTYRQSDSETCGG
What is the function of this protein?
Rapidly hydrolyzes choline released into the synapse.
What are the official names of this protein?
Acetylcholinesterase 1, AChE 1.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein. Note=May be secreted or membrane associated via a non-catalytic subunit.
Protein: SSI8_STRVG
Sequence: SLYAPSAMVFSVAQGDDVAAPTVVRATTVSCAPGARGTHPDPKAACAALKSTGGAFDRLLSEPNPDRACPMHYAPVTVSAVGVWEGRRVAWDHTFANSCTMAATLDGNAVF
What is the function of this protein?
Inhibitor of subtilisin and chymotrypsin.
What are the official names of this protein?
Subtilisin inhibitor-like protein 8, SIL-8, SIL8.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I16 (SSI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPP2_BACLD
Sequence: MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDISIYINSPGGSTSAGYAILDTMDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEIMIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQPIEKLKADMERDYFMDADEAKAYGVIDAVL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH_DROAM
Sequence: MSLTNKNVIFVAGLGGIGLDTSRELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTVPISETTKLLKTIFAQLKTVDVLINGAGILDDYQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGSKAAVVNFTSSLAKLAPITGVTAYTVNPGITKTTLVHKFNSWLDVEPNVAEKLLEHPTQTSQQCAENFVKAIELNKNGAIWNLDLGTLEPITWTQHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.