PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_MYCBO
Sequence: MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMSDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: EREL2_ARATH
Sequence: MQRRSPPKHRHDGASPLPLGMDWSPPPRNWNGRDTIWPHDFRTGWSYCVTIPSWTLLSKSKNSDPIVFYRVQVSVQSPEGVSTMRGILRRFNDFVKLLADLKRAFPRKSFPSAPPKGFLRVKSRDMLEERRCSLEDWMTKLLSDIELARSVVVASFLELEATARSACQVVDQNASDSNDDGNSTSLSSLVHPNSGGSSLLSSDYGSDTAYETSELGSASLGQDDVSETDTGDLTLDEDLTNPTEKLVKFSMSNIDEGLSMSQTIIEQLEDFPKHRVHLGYANDITETNSYNGKASKGVFRANNDLRCRSESETSHSVMHDRKLSLESADGVSLLAGETSTSSILSSIVHSQLDVNHDISVGNLEIPGNGRIVLPLKMHSKLNRILLTMNERLLNSKTDMEDLIARLNQETAVKEYLNRKVDDLEVELETTKQRNKENLEQALMTERQSVTKMQWDMEELRQKTFEMELKLKSKEDGSSDSKTSGNSTISESHELLQEMDATKQQLEDLSRRYVELEAKSKADIKVLVREVKSLRRSHMEMEKELTRSLTEKSDTEKLLQQERIIVENTLEARRRLYSDCEILHDRLKVNNTNLSMDESSNNREDLSEVSNALQDQIEAQLLLGFDETASEDELRKIMADMYED
What is the function of this protein?
Acts as an effector of RABF2A and RABF2B (By similarity).  Involved in vacuolar transport of storage proteins.  Regulates membrane trafficking to protein storage vacuoles (PSVs) (Probable).  Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P) (By similarity).
What are the official names of this protein?
PX domain-containing protein EREL2, Protein EREX-like 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=The endosomal localization depends on the active state of RABF2B.
Protein: DNLJ_PSEFS
Sequence: MTAAHTRILELRAELDQHNYRYHVLDEPSIPDAEYDRLFHELKALEAEHPDLVTRDSPTQRVGSAALSAFTQVKHDIPMLSLGNAFDETTMLEFDRRVTEGLDLPVGDLFGGGAAVEYSCEPKLDGLAVSLLYQDGELVRGATRGDGTTGEDISVNIRTVRNIPLKLHGSGWPATLEVRGEVFMSKAGFERLNASQLEVGGKTFANPRNAAAGSLRQLDSKITASRPLEFCCYGVTTDISDTHIGNLQQLKKWGMPISHELKLAKGIQDCLDYYRDIGERRNSLPYEIDGVVFKVNSIASQRELGFRAREPRWAIAHKFPAMEELTELLDVEFQVGRTGAVTPVARLKPVKVAGVTVSNATLHNMDEVARLGLMIGDTVIIRRAGDVIPQVVSVVPERRPENARAVQIPESCPVCGSHVERTQLVKRSKGKETVSEGAVYRCVGRLACGAQLKQAIIHFVSRRAMDIDGLGDKTIEQLVDEKLIGSPADLYTLKYEQIIDLEGFADISSKKLITAIENSKTPTLARFIYALGIPDVGEETAKVLARSLASLERVQKALPEVLTYLPDVGLEVAHEIHSFFEDSHNQDVIGALLSPQACGLQLQDQGELSAEFAASTTLGGLLDKLHVPSVGPGAAQKLADKFVTLEGVIKADWLDMRQALPEKQAKAVREFFDNADNANHALAIEQQLKDFGMHWDSEKKVVEGLPEAGHTWVLTGSLELMSRDVAKDKLESLGAKVAGSVSAKTHCVVAGPGAGSKLAKASELGLKVLDEEAFVAFLAKHNIPV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL10_MYCPN
Sequence: MEAKKDKAQQVADVSHLLSTSAGFVIFDYTSMSAIEATSIRKKLFKNGSKIKVIKNNILRRALKAGKFEGIDETAIKGKLAVAVGVNEIVETLKAVDGVVKAKEAMNFVCGYFDNRAFNSADLEKIAKLPGRNELYGMFLSVLQAPLRKFLYALEAVKAAK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ARCD1_LACLM
Sequence: MDAENKKGIGLAALVAIIVSGAIGGGVFNLSNDLATNASPGGVVISWIVIGFGILMLVLSLNHLVVNKPELSGVSDYARAGFGNMVGFISGWGYWLSAWAGNIAFAVLMMTSVDYFFPGVFQAKNGSLTILSVIVVSIVSWGLTLLVMRGVEGAAAINAIVLVAKLIPLFVFVIAGIVTFKAGVFSAHFWQNFVANTNADGVIKSLTWSNMTGGDLFSQVKGSLMVMIWVFVGIEGAAMMGDRAKRKSDAGKASIFGLIALLVIYILLSLLPFGFMSQQELANTGQPGLVHILNAMVGGWGGSLMAIGLVISLLGAWLSWTMLPVEATQQLSEQKLLPSWFGKLNDKGAPKNSLLLTQLIVQIFLIVTYFVADAYNVFVYLCTAVIMICYALVGLYLFKLGIQEKKTSNIIIGFIAAAFQILALYYSGWQFVWLSLILYAVGFILYALGKKEYGTKMSTTEVIATFILTVLGILAVFGVYGNWLGLQDALGIDGNTLLVAVVPLIVVTFIVYFVVRSDINKKGIKN
What is the function of this protein?
Catalyzes electroneutral exchange between L-arginine and L-ornithine (PubMed:23144255, PubMed:26324452).  Can also efficiently translocate L-histidine and L-lysine (PubMed:26324452).  ArcD1 is the main L-arginine/L-ornithine exchanger in the arginine deiminase (ADI) pathway (PubMed:26324452).
What are the official names of this protein?
Arginine/ornithine antiporter ArcD1, Arginine/ornithine exchanger.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: S2538_BOVIN
Sequence: MIQKSRPALLQHQDVGDRVETLMLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHRTDQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS
What is the function of this protein?
Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: XPT_CLOBB
Sequence: MENLHKRILEEGQALSNDVLKVDSFLNHQVDADLMYEMGTYFKNYFKDHNITKIFTIESSGIAPTVMTAMQMNLPMVILKKQGSKILKGDVYQTTVHSFTKGTDYELTLQKKYINEDDNILIIDDFLANGEAALGAARLVEGAGAKVAGIGIVIEKSFQPGPKLLEEKGYDVYSLARIEKLEKGIIKIKK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOGG_XENLA
Sequence: MDHSQCLVTIYALMVFLGLRIDQGGCQHYLHIRPAPSENLPLVDLIEHPDPIYDPKEKDLNETLLRTLMVGHFDPNFMATILPEERLGVEDLGELDLLLRQKPSGAMPAEIKGLEFYEGLQSKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRCQRRVQQKCAWITIQYPVISECKCSC
What is the function of this protein?
Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling.  Binds BMP-4 and BMP-2 with high affinity.  Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors.  Capable of inducing dorsal development in embryos.  Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA.  None of these molecules causes dorsal mesoderm formation when expressed alone.
What are the official names of this protein?
Noggin.
What is the protein family that this protein belongs to?
Belongs to the noggin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMM_PAEAT
Sequence: MSRLFGTDGVRGLANGLLTAELAMQLAQAAAVVLGHDRTTDGKRPRAVVARDPRASGEFLAAAVEAGLSSSGIDVYDAGVLPTPAAAYLVADLDADFGVMLSASHNPAPDNGIKFFARGGQKLPDDVEDAIEAQLGKEPQRPVGADVGRIQRFSDAEDRYIVHLLGTLPKRLEGLKVVLDCAHGAASGCSPQVFKDAGAEVVVIGAEPDGLNINDGVGSTHLGPLKEAVVKHGADLGVAHDGDADRCLAVDHEGNEVDGDQIMAILALALKEAGKLKDNILVATVMSNLGLKIALRDAGITIRETGVGDRYVLEEMRDGGYNLGGEQSGHVIFSDFATTGDGVLTGLQLAAQVALTGRSLKDLSSAMTKLPQLMINVKDVDKARAATDEGVAEAVAAAELELGETGRVLLRPSGTEALVRVMVEAADMETAERICKGLAAVVKERLGAPSELAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: U763_DORVU
Sequence: MFKPRVILLITIIAVFSEFKKAFKGLFEKAANKYLH
What is the function of this protein?
Peptide with insecticidal and antiparasitic activities.  Induces irreversible paralysis in D. melanogaster when tested at high doses.  It shows a moderate antiparasitic activity against the major pathogenic nematode of ruminants (H. contortus, EC(50)=41. 3 uM).  Does not show antimicrobial activities.  Does not induce increase in intracellular calcium in mouse DRG neurons, suggesting that it does not induce pain.
What are the official names of this protein?
U-limacoditoxin(7)-Dv63, U-LCTX(7)-Dv63, Cecropin-like peptide, Vulnericin.
What is the protein family that this protein belongs to?
Belongs to the limacoditoxin-7 family.
What are the subcellular locations of this protein?
Secreted.
Protein: AB19A_PRUPE
Sequence: MIFPIFFTFFLLLSSSHASVQDFCVADYKAPDGPAGYSCKKPAKVTINDFVYSGLGIAGNTTNIIKAAVTPAFAAQFPGVNGLGISLARLDLGPGGVIPFHTHPGASEVLLVVQGTIIAGFVASDNTPYLKTLKKGDIMVFPQGLLHFQVNGGGTPALAFPSFSSPSPGLQILDFALFKNDLPTELIAQTTFLDAAQIKKLKGVLGGTN
What is the function of this protein?
Probable receptor for the plant growth-promoting hormone auxin.
What are the official names of this protein?
Auxin-binding protein ABP19a.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast. Secreted, cell wall.
Protein: PYRE_SERP5
Sequence: MKAYQRQFIEFALNKQVLKFGEFTLKSGRTSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHERDVPYCFNRKEAKTHGEGGTLVGSPLQGRVMLVDDVITAGTAIRESMEIIGAGGATLAGVLISLDRQERGRADISAIQEVERDYHCKVISIVTLKDLIVYLEEKPEMADHLAAVRAYREQYGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: HSLV_ECOSM
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDL21_ARATH
Sequence: MISPTMEQGESLRIRVVMGKDRISELPDGLLLKILSSLPTNIVVATSVLSKQWRSLWKLVPNLEFDSDDYESEHYTFSEIVCKSFLSHKAPVLESFRLKFVNFNPVDIGLWVGIAFSRHLRELVLDFYPAELGKGVTFTFPSSLCTCNTLETLKLVLCILVDIPSPVLMKSLRTLHLEFVRYKDESSVRNLLSGCPGLEELRLYRGDDSDIKVFTIEVPSLQRLTIHDNNDGPEFWGYVINAPFLKYLLIEELRCPEFCLNAPELVEANIAEVTSITIEKFLGSFTSVSRLLLNLSPLKITYPTGSMFYQLVSLEMYTREAEWWNLLTLMLENSPKLQVLKLTDRSQNFHKDGLVSGKWNEPKDVPECLLSQLETFVWRRFDWGREEEKEIATYILKNGRRLKKATFSTNPIESEELNKLKERRKVLNGLDGVVRASNSCQLVFKFDPSYLGSDSP
What are the official names of this protein?
F-box/FBD/LRR-repeat protein At3g52680.
Protein: DER_DESAH
Sequence: MKPVVALVGRPNVGKSTLFNRITRSRNALVDDFPGVTRDRHYVDAVWNERPFTLVDTGGFLLSDDDFFAREIRGHVELAIEDADIVALVLDGRAGISPFDRDLADILRRTSKPVFFLVNKVENHKQREELLEFYSLGIEKFYPMSAEHGIGVEPFLDDMVALFPAPEPVVEPQAGSEQGEPDASEQEICIAVAGRPNVGKSSLINRLFGKSRVVVSHVPGTTRDSVDLSIERNGRRFRLIDTAGIRRKGKVRERIEKYSILKSLKSLDQCDVALILIDADEGVTDQDITIAGYAQDRGCGALFLINKWDLLDEDRKDQRRFMEDLRTKSKFLSFAPAMTISALTGFRTHKILAMVEKIHAQYAYRINTGLLNRIVEDAIFRSEPPMHKGKRLKFFYATQVAVKPPTIVCFVNYPDAVHFSYHRYLVNQIREMAELEHTPIRLLFRAKTGKIDFSGKSKLAERIVEKKEKKTTRRKKERKEQSRRKRVRDLKG
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATB20_ARATH
Sequence: MYVFDPTTEAGLRLEMAFPQHGFMFQQLHEDNSQDQLPSCPPHLFNGGGNYMMNRSMSLMNVQEDHNQTLDEENLSDDGAHTMLGEKKKRLQLEQVKALEKSFELGNKLEPERKIQLAKALGMQPRQIAIWFQNRRARWKTRQLERDYDSLKKQFESLKSDNASLLAYNKKLLAEVMALKNKECNEGNIVKREAEASWSNNGSTENSSDINLEMPRETITTHVNTIKDLFPSSIRSSAHDDDHHQNHEIVQEESLCNMFNGIDETTPAGYWAWSDPNHNHHHHQFN
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein ATHB-20, HD-ZIP protein ATHB-20, Homeodomain transcription factor ATHB-20.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SL6_BITAR
Sequence: MGRFIFVSFGLLVMFLSLSGTEAGVCCPFGWSGYDQNCYKAFEELMTWADAEKFCTQQHKGSHLLSLHNIAEADFVVKTTVSGSKDGVIWMGLSDVWNECNWGWTDGAQLDYKAWNVASNCFIFKTAENNWSRTDCSGTHNFVCKSPA
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec 6, C-type lectin 6, CTL-6.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: SUOX_MOUSE
Sequence: MLLQLYRSVVVRLPQAIRVKSTPLRLCIQACSTNDSLEPQHPSLTFSDDNSRTRRWKVMGTLLGLGVVLVYHEHRCRASQESPRMYSKEDVRSHNNPKTGVWVTLGSEVFDVTKFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQPHVRELLAEYKIGELNPEDSMSPSVEASDPYADDPIRHPALRINSQRPFNAEPPPELLTEGYITPNPIFFTRNHLPVPNLDPHTYRLHVVGAPGGQSLSLSLDDLHKFPKHEVTVTLQCAGNRRSEMSKVKEVKGLEWRTGAISTARWAGARLCDVLAQAGHRLCDSEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVESEESYSHWQRRDYKGFSPSVDWDTVNFDLAPSIQELPIQSAITQPQDGAIVESGEVTIKGYAWSGGGRAVIRVDVSVDGGLTWQEAELEGEEQCPRKAWAWRIWQLKAQVPAEQKELNIICKAVDDSYNVQPDTVAPIWNLRGVLSNAWHRVHVQVVP
What is the function of this protein?
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
What are the official names of this protein?
Sulfite oxidase, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: ENV_EIAV1
Sequence: MVSIAFYGGIPGGISTPITQQSEKSKCEENTMFQPYCYNNDSKNSMAESKEARDQEMNLKEESKEEKRRNDWWKIGMFLLCLAGTTGGILWWYEGLPQQHYIGLVAIGGRLNGSGQSNAIECWGSFPGCRPFQNYFSYETNRSIHMNNNTATLLEAYHREITFIYKSSCTDSDHCQEYQCKKVNLNSSDSSNSVRVEDVTNTAEYWGFKWLECNQTENFKTILVPENEMVNINDTDTWIPKGCNETWARVKRCPIDILYGIHPIRLCVQPPFFLVQEKGIADTSRIGNCGPTIFLGVLEDNKGVVRGDYTACNVRRLNINRKDYTGMYQVPIFYTCTFTNITSCNSEPIISVIMYETNQVQYLLCNNNNSNNYNCVVQSFGVIGQAHLELPRPNKRIRNQSFNQYNCSINNKTELETWKLVNTSGITPLPISSEANTGLIRHKRDFGISAIVAAIVAATAIARSATMSYVALTEVNKIMEVQNHTFEVENSTLNGMDLIERQIKILYAMILQTHADVQLLKERQQVEETFNLIGCIERTHVFCHTGHPWNMSWGHLNESTQWDDWVSKMEDLNQEILTTLHGARNNLAQSMITFNTPDSIAQFGKDLWSHIGNWIPGLGASIIKYIVMFLLIYLLLTSSPKILRALWKVTSGAGSSGGRYLKKKFHHKHASREDTWDQAQHNIHLAGVTGGSGDKYYKQKYSRNDWNGESEEYNRRPKSWVKSIEAFGESYISEKTKGEISQPGAAINEHKNGSGGNNPHQGSLDLEIRSEGGNIYDCCIKAQEGTLAIPCCGFPLWLFWGLVIIVGRIAGYGLRGLAVIIRICIRGLNLIFEIIRKMLDYIGRALNPGTSHVSMPQYV
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: ODO2_HUMAN
Sequence: MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
What is the function of this protein?
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex.  The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).  The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736).  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, E2K.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: TVA30_HUMAN
Sequence: METLLKVLSGTLLWQLTWVRSQQPVQSPQAVILREGEDAVINCSSSKALYSVHWYRQKHGEAPVFLMILLKGGEQKGHDKISASFNEKKQQSSLYLTASQLSYSGTYFCGTE
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 30.
What are the subcellular locations of this protein?
Cell membrane.
Protein: TRP_COPC7
Sequence: MEAIKKVFEQKKAQDATAFVAFVTAGYPKKEDTVPVLLALQAGGADIIELGIPFSDPIADGPVIQEANTVALKNDIDYPTVLGQIREARQQGLTAPVLLMGYYNPMLAYGEDKAIQDAAEAGANGFIMVDLPPEEAIAFRQKCAASNLSYVPLIAPSTTLKRIQFLASIADSFIYVVSKMGTTGSSANVAVNEELPTILSRIREYTHVPLAVGFGVATRDQFNYVADAGADGVVIGSRIVNAIKAAGDGEVPQFVENYCREVSGKGEPSRVRSPGAAQRTPSQLTPNAETAKGVENILPARFGQFGGQYVPESLVDALAELEEAHKSAIEDPAFWEEVRSLYTYSNRPSNLYLAENLTKEAGGANIWLKREDLNHTGSHKINNALGQILLAKRIGKTRIIAETGAGQHGVATATVCAKFGLECVIYMGAEDVRRQALNVFRIEMLGGKAWVIPVHSGSCTLKDAVNEAMRDWVTNLSTTHYLVGSAIGPHPFPTIVRDFQKVIGEEIKAQLKEVRGKLPDVVVACVGGGSNAIGTFYDFIPDKSVRLVGVEAGGEGIDGHKHSATLSMGQPGVLHGVRTYILQDKAGQIIETHSISAGLDYPGVGPEHAWLKDSGRADYVVCTDEDALRGFRMLTQKEGIIPALESSHAIWEGVKIAKSLPKDKDIVICLSGRGDKDVEQISELLPKWADKLDWHVSSNAIPSK
What are the official names of this protein?
Tryptophan synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the TrpB family.
Protein: BIOB_PROMS
Sequence: MINSNNQVLSEIRFDWNKKEILEILNMPLIDLMWESQIVHRKFNSYNIQLASLFSVKTGGCEENCSYCSQSIYSASEIKSHPQFQVEEVLARAKIAKNEGADRFCMGWAWREIRDGKSFNAMLEMVSGVRDLGMEACVTAGMLTEEQASRLADAGLTAYNHNLDTSPEHYKNIITTRTYQDRLDTIKRVRNAGINVCCGGIIGLGETNGDRASLLEVLSNMNPHPESVPINSLVAIEGTGLEDNQEIDSIEMIRMIATARILMPKSKIRLSAGREKLSKEAQILCFQCGANSIFYGDELLTTSNPSFQSDRKLLKEVGVSFNKDFETCEKTLSSL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CYB6_DAUCA
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTDAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPRDQIGYWAVKIVTGVPEAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFPMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.