PharMolix/UniProtQA huggingface dataset:
Protein: RS19_STRS7
Sequence: MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: COX2_GADMO
Sequence: MAHPSQLGFQDAASPVMEELLHFHDHALMIVFLISTLVLYIIVAMVSTKLTNKYILDSQEIEIIWTVLPAVILILIALPSLRILYLMDEINDPHLTIKAMGHQWYWSYEYTDYEDLGFDSYMIPTQDLAPGQFRLLEADHRMVVPVESPIRILISAEDVLHSWAVPALGIKMDAVPGRLNQTAFITSRPGVFYGQCSEICGANHSFMPIVVEAVPLEHFESWSSLMLEDA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DDX46_DICDI
Sequence: MDEYDKKRRLEHGGSDRSRSSNDNRNSHGSSGNNYRDDRKDDRYYRDDRSHYNNNNNNNNNNNNNNNNNNGNGYRDDRNYSSQNKYQNHHQQSPPQQQQQQQNSSYVPSQPPQQQTQTQQQPHIQAPPPAKPRKSRFDQAPETIPIQAPQQPPMISNQPIFKQQPMYQQPMYQQKQQQPQPPIFQQQQKQQQPPIFQHHQPPPIYQQPPVYQQQQQQQQPVFQQQQQQRVATEAIQFQQTPQQLAIEQERLKQERENEKKIEQANLEEEMKKRREKVEQWRKQKLEQELKASGSSNSGSTSSPPTTTTTTTKTTAATTTATTSPLTIPSQQQQTATTSPIKKKWSLEEEEETAQPLVNTNIEQKEIKLPPTANIPAAAATTTSATINTTTIKQSIEEDDDIDPLDAYMENLNKEANLNLKKSKTSQMIDDDEKLEEESEGEDDGKDKTIKKGKKEMLHTDHTSIKYAEFQKNFYIEVPVLANMTETEVLDFRSELGVKITGKDCPKPIQSWAQAGLTEKVHLLLKKFQYEKPTSIQAQTIPAIMNGRDLIGIARTGSGKTLAFLLPMFRHILAQPKSAPGEGMIALIMSPTRELALQIHVECKKFSKVLGLRTACVYGGASISEQIAELKRGADIVVCTPGRMIDILCANNRRITNLRRVTFLVLDEADRMFDMGFGPQINCIVDSIRPDRQTIMFSATFPPKVENVAKKILNKPLEIIAGGRSIVSSDIEQFVEVRPTETRFRRLIELLSIWYHKGQILIFTNRQETTDNLYRQLSNSQYQCLSLHGSKDQTDRDETISDFKNKVKTILIATPLASRGLDIKDLNLVVNFDCPDHLEDYVHRVGRTGRAGNRGTAYTFITPDEERFSSSIIKALEQSGSKVPDELRKLNDTYEKKRKEGKDVLLAPTGFTGRGHKFDAAEEDKKNIERKQQRKAYGIEEEEEEEDEDKEKAEKEKLAAASAEKEKQLLSEKEKLDPATTNTIVIPGVDGTIITPSSLLQTDPSVPVGQQAINQIFGISQVTSSEEAIKKLQLAAQLGMKGNIQKLNNQITPLNQTHFIEELEINDYSQQARWKVTHKDALLEITNFTNTTITTKGTFFPPNKIPAPGERKLYLYIEGPSDASVKNAKSDIKKILDEVQSTHQSTGKYSVF
What is the function of this protein?
ATP-dependent RNA helicase which may be involved spliceosome assembly and in nuclear splicing.
What are the official names of this protein?
ATP-dependent RNA helicase ddx46, ATP-dependent RNA helicase helB1, DEAD box protein 46.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPF_SHELP
Sequence: MNIRIGHGFDVHKFGGELPLILGGVEVPYDTGLVAHSDGDVVLHAISDAILGAMALGDIGKHFPDTDPDFKGADSRVLLRHCYQLALDKGYRLGNLDVTIIAQAPKMLPHIQAIRECLSADLESDIEAINVKATTTEKLGFTGRKEGIAVEAVVLMCAAPR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: VPE1_ORYSJ
Sequence: MAARCWVWGFVVALLAVAAAADGEEEEGKWEPLIRMPTEEGDDAEAAAPAPAPAAADYGGTRWAVLVAGSSGYGNYRHQADVCHAYQILQKGGVKEENIVVFMYDDIAHNILNPRPGTIINHPKGGDVYAGVPKDYTGHQVTTENFFAVLLGNKTAVTGGSGKVIDSKPEDHIFIYYSDHGGPGVLGMPNLPYLYAGDFIKVLQKKHASNSYSKMVIYVEACESGSIFEGLMPENLNIYVTTASNAVENSWGTYCPGEEPSPPPEYITCLGDMYSVAWMEDSETHNLKKETIEDQYELVKKRTSNANKLNEGSHVMEYGDKTFKDEKLFLYQGFNPANGNITNELIWPVPKATVNQRDADLLFMWKRYEQLNGVSEDKLRALREIEDTIAHRKHLDSSIDFIGKLVFGFENGPLALEAARSSGQPLVDNWDCLKKMVRIFESQCGSLTQYGMKYMRAFANICNNGVSEAKMMEASINACGRYNSARWSPMTEGGHSA
What is the function of this protein?
Asparagine-specific endopeptidase that may be involved in processing of proteins targeted to vacuoles.  Cysteine protease required for post-translational proteolysis of seed storage proteins in the protein storage vacuole (PSV) of developing seeds, by processing of proglutelin precursor to mature glutelin subunits, thus contributing to the formation of protein crystalline structures in PSV (Ref. 1, PubMed:19154227, PubMed:19933265).
What are the official names of this protein?
Vacuolar-processing enzyme beta-isozyme 1, Beta-VPE 1, OsVPE1, Asparaginyl endopeptidase VPE1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
Protein: PYRD_PSESM
Sequence: MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLGKSAAKLPVSVMGLEFPNPVGLAAGLDKNGAAIDGFAQLGFGFVEIGTVTPRPQPGNPKPRIFRLPNAEAIINRMGFNNLGVDNLVSRVEAAKYRGILGINIGKNFDTPVERAVDDYLICLDKAYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLEALSLRQQELTQRHGKRVPLAIKIAPDMTDEETVLVAAALIESGMDAVIATNTTLSRQGVEGLPHGDEAGGLSGAPVREKSTHIVKVLAGELAGRMPIIAAGGITEGRHAAEKIAAGASLVQIYSGFIYKGPALIRQSVDAIAAMPRTAS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SNX30_XENTR
Sequence: MSGSSTPKSLPTSGQQSLHDIKHPLSCSPSAEDDAAGENGAVIIESPSPDLPNTEPSSLADKDLSLPNGTPADTSSPASSSSLLNRLQLDDDLDGETRDLFVTVDDPKKHVCTMETYITYRVSTKTTRTEFDLPEYSIRRRYQDFDWLRNKLEETQPTHFIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRIADHPVLSFNEHFNVFLTAKDLNSHKKQGITLLSKMGESVRYVTSGYKLRNRPVEFATITDYLDTFQLKLGTIDRIAQRIIKEEVEYLMELREYGPVYSTWSGLERELNEPLEGVSACVGNCSTALEELTEDMSEDFLPVIREYMLYSESMKTVLKKRDQVQAEYEAKAEAAALKREERSTVPTDVEKCQDKVECFNADLKADMDRWQNNKRQDFRQLLMGMADKNIQYYEKCLTAWESIIPLLQDKQEPK
What is the function of this protein?
Involved in the regulation of endocytosis and in several stages of intracellular trafficking.  Together with snx4, involved in autophagosome assembly.
What are the official names of this protein?
Sorting nexin-30.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL17_BIPLU
Sequence: MGRYAREPDNAGKSCKARGSNLRVHFKNTCETANAIRKMPLKRAVAYLKNVTAQKECVPFRRFNGGVGRCAQAKQFGTTQGRWPKKSAEFLLQLLRNAESNADYSGLDVDRLVVQHIQVNRAACLRRRTYRAHGRINPYMSSPCHIELWLTEAESVPEAAKKPGKKTSAVEKSKKATAATH
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RSMH_PSE14
Sequence: MNSGFTHITVLLEEAVEALEVRADGCYLDGTFGRGGHSRLILSQLGPDGRLLGFDKDPQAIATGQALAAEDGRFVIVQRSFAELGSEAQERGLAGKVSGILLDLGVSSPQLDDPERGFSFMNDGPLDMRMDPTRGVSAAEFIATAPAEEIARVFKEYGEERFAKRMANAVVARREVQPFERTADLAEVLKVANPAWEKGKNPATRAFQGLRIHVNNELGDLEAGLEAALDALEVGGRLVVISFHSLEDRIVKLFMRKLAKGEADNMPRNLPIQFKPFEPKIKIHGKAQFASDTETKANPRSRSAVMRVAEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y640_GEOKA
Sequence: MSEPLHALAKQLEQAIRASEPFQQLKRAYEDVRRDETAYRMFANVRDIQLQLHEKQMRGAAILPDEIEQAQKAMALAQQNEKLARLMALEQQMSMTIAEVQQIAMKPLEELHRSFMEGR
What are the official names of this protein?
UPF0342 protein GK0640.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: PSAJ_GOSBA
Sequence: MRDLKTYLSVAPVLSTLWFGSLAGLLIEINRFFPDALTFPFFLIRVIVAGRGEKD
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DUT_HUMAN
Sequence: MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
What is the function of this protein?
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593).  Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity).  Essential for embryonic development (By similarity).
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
What are the subcellular locations of this protein?
[Isoform 2]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion.
Protein: CENPT_HUMAN
Sequence: MADHNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQTPRTLLKNILLTAPESSILMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSVFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQRPGLARRPPARRAVDVGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVEPLHDGVEEAEKKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGASSGDEDASGRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRPRTTGPRPRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAHAGRKTVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.  Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA.  Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly.  CENPT has a fundamental role in kinetochore assembly and function.  It is one of the inner kinetochore proteins, with most further proteins binding downstream.  Required for normal chromosome organization and normal progress through mitosis.
What are the official names of this protein?
Centromere protein T, CENP-T, Interphase centromere complex protein 22.
What is the protein family that this protein belongs to?
Belongs to the CENP-T/CNN1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus.
Protein: NCAP_I76AF
Sequence: MASQGTKRSYEQMETGGERQNTTEIRASVGRMIGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRIDGKWIRELILYDKEEISRIWRQANNGEDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQKAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGKRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRIMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YQGF_CLOB1
Sequence: MRILGLDIGDRTIGIAISDPLGFTAQGITTIRRKSEAYDLEEIKKICDKYEVDTIVSGLPKNMNGTLGPQSEKVLEFCDLIKEHLNIEIKMWDERLTTVAATRAMLEADLSRSKRKKIVDKVAATYILQGYLDSLSK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP1A2_MACFU
Sequence: MALSQFVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGDDFKGRPDLYSFTFITDGQSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSGNPVDFFPILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDKNSVQDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAEFDTIATAISWSLMYLVTKPEIQRKIQKELDAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTTLNGFYIPRECCVFINQWQVNHDPQLWGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHFQARLRFSFQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2.  Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis.  May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer.  Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).  Plays a role in the oxidative metabolism of xenobiotics.  Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.  Metabolizes caffeine via N3-demethylation.
What are the official names of this protein?
Cytochrome P450 1A2, CYPIA2, Cholesterol 25-hydroxylase, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: NUON_YERPP
Sequence: MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLVIIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLASANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYMLLSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVSTFLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHELALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVVAMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLVQMAQPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNP_ECOUT
Sequence: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPRGDISEFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEITAEIEVGRVYNGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRIRLSIKEATEQSQPAAAPEAPAAEQGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_CLOPA
Sequence: MRSDSARKGLEKAPHRSLFKALGFIDEEMERPLIGIASSYSEIIPGHMNLDKVVQAVKDGVRMAGGVPVTFGTIGVCDGISMNHKGMSYSLPSRQLIADSVEIVASAHAFDGIVLVPNCDKVVPGMMMAAARLDIPAIVISGGPMLAGNTCGKATDLSGVFEAVGAVKAGNMTEEELSELENTACPTCGSCSGMYTANSMNCLSEVLGLALPYNGTIPAVYSERLRLAKTSGMKIVDLVKKGLTPSKILTEEAFMNAITADMALGCSTNSLLHLPAIANEVGITID
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.  Is specific for the (R) isomer of 2,3-dihydroxy-3-methylbutanoate, with no catalytic activity against the (S) isomer.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ZN607_HUMAN
Sequence: MSYGSITFGDVAIDFSHQEWEYLSLVQKTLYQEVMMENYDNLVSLAGHSVSKPDLITLLEQGKEPWMIVREETRGECTDLDSRCEIISDGKMQLYRKHSCVTLHQRIHNGQKPYECKQCQKSFSHLTELMVHQTIHTSEEPDQCEKFRKAFSHLTDLRKHQKINAREKPYECEECGKVFSYPANLAQHGKVHVEKPYECKECGEAFRTSRQLTVHHRFHYGEKPYECKECGKAFSVYGRLSRHQSIHTGEKPFECNKCGKSFRLKAGLKVHQSIHTGEKPHECKECGKAFRQFSHLVGHKRIHTGEKPYECKECGKGFTCRYQLTMHQRIYSGEKHYECKENGEAFSSGHQLTAPHTFESVEKPYKCEECGKAFSVHGRLTRHQGIHSGKKPYECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAFSQRAHLAHHNRIHTGYKPFECKECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIHRRVHTGEKPYECKECGKAFSVSGQLTQHLSIHSGKKPFECNKCGKSFRFISVLKAHQNIHSAEKPYECKECGKAFRHATSLIYHDRTHAGEKSYECKECGETFSHASHLIIHERIHTSDKPYECKRCGKAFHCASYLVRHESVHADGNPYMCEECGKAFNSSHELSIHHRVHTGEKPFKCNKCRRSFRLRSILEVHQRIHI
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 607.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SP2AB_CLOP1
Sequence: MDNKMRLEFLAKSENEGFARVSVSAFIAQLDPTIEELTDIKTAVSEAVTNAIIHGYECDESKVVIIEASICEDEISITVEDNGIGIENLEEAREPLYTSKPELERSGMGFTVMETFMDSLEVYSEKDKGTKIIMKKKMNT
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.