PharMolix/UniProtQA huggingface dataset:
Protein: NU2M_NYCAR
Sequence: MNPMTFSLIMMTMVSGTFLVMMSSHWFLIWVGFEMNMLAIIPLLTKQHNPRSTEAATKYFLTQATASMLLMMAAIINLLYSGHWSVQKLINPMASVTMTMALAMKLGLAPFHFWVPEVTQGIPLSSGLILLTWQKLAPLSIMYMISPLTNLNILMIMALLSIAIGGWGGLNQTQLRKIMAYSSIAHMGWMMSVLMYNPNMMLLNLYLYIPMTITTFSLLMINSTTTTTSLSYTWNKLPLITMIILITMLSLGGLPPLTGFLPKWLIIQELVKNNNIILSTVMALLALLNLYFYTRITYTTSLTLFPTMNNTKITWQFKYPKQMLYLPLMIIISTLILPVSPMTAILE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IGHA_EQUAS
Sequence: ASVTSPSIFPLSLRKADSGDPVVIACLIKGFFPLGFPEPVKVTWGKSGVVTNYLPSEAGGLYTVISQLSLRADQCPDDASVKCEVQHYTSPSKSVDVPCIVCPPPPPCPCECLLSTVPRLSLSPPAEDLLLSSNASLTCTLRGLRDPKGATFTWSPSSGNVPVLQEPKLEPSGCYSVSSVLPGCAEPWSKKETFSCTASHPELKKSQTVSITKPKEPLFQPQVHVLPPPSEELALNELVTLTCLVRGFSPKEVLVLWLQGHEKLPREKYLVFKPLREPGQSVPTFAVTSLLRVEAEAWLRGDVFSCMVGHEALPLSFTQKSIDRLSGKPTHVNVSVVMAEADGTCY
What is the function of this protein?
Constant region of immunoglobulin heavy chains.  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens.  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.  Ig alpha is the major immunoglobulin class in body secretions.
What are the official names of this protein?
Immunoglobulin heavy constant alpha, Ig alpha chain C region, IgA constant region.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CTTB2_MICMU
Sequence: MATDGASCEPDASRAPEEAAGATAEAARKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMATQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEEAMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGPLTRSVACQTDLAIEGTDHVKKSPLTVPGKPSPGSAKGSVCANAAHVRPGMDRQASHGDLTGSSAPSLPPASANRIEENGPSTGSTADLPSSTAPAPGSAAQSPVAAALGPAHSAQSPCTPAPAQPGLNPRVQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPAVGAAPRPGAPPTGDAGAYPPVGRTSLKTPGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIMDSSRASNAGAKVDNKTVASPPSSLPQGNRVISEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAETPGLNQPACSDSSLVIPTTTAFRSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTDRSVKTRDGWTPVHAAVDTGNVDSLKLLMYHRAPAHGNSLNEEEPESDVSDLDDGEESSEGESKPVVPADLINHADREGWTAAHIAASKGFKNCLEILCRHRGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIQSGNYGSSDFECENTICVLHIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDTAFNNTADSDIGLSLDSVRAIMLGSVPWSAGQSFTQSPWDFMRKNKAEQVTVLLSGPQEGCLSSVAYASMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLVDLFISSACLIPVKQSPVKKKIIIILENLEKSSLSELLGDFLAPLEIRSPESPCTFQKGNGTSECYYFHENCFLMGTIAKACLQGADLLVQQHFRWVQLRWDGEPMHGLLQRFLRRKLVNKFRGQAPSPCDPVCKTIDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQATVKWMSKLWNAVIAPRVQEAILSRASVKRQPGFGQTTTKKHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSLVSNYNSCSKKKENGAWRKVNTSPRRKSGRFSSPTWNKPDLSNEGIKNKTISQLNCNKNASLSKQKSLENDLSLMLNLDPRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRTFDSSGNNPAFSATVNNPRMPVSQKEVSPLSSHQTTECSNNKSKTEPGVSRVKSFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNSKEENWNLHKNEQTHRKT
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: PLSX_RHIME
Sequence: MVRISLDVMGGDYGPEVVIPGAARALERHPDIKFVLFGQEARCIELLAKHPKLKASSTFHDCEIAVGMDEKPSQALRRGRGKSSMWKAIDAINADEADVVVSAGNTGALMAMSVFCLRTMQGIQRPAIAAIWPTLKGESIVLDVGATIGADAQQLMDFALMGGAMARALFEVERPSVGLLNVGVEEIKGQEEVKEAGRLIREADVEGIEYYGFVEGDDIGRGTVDVVVTEGFSGNIALKAAEGTARQIAEYLRAAMSRTLLARVGYVFAKGAFDRLREKMDPRKVNGGVFLGLNGIVIKSHGGADAEGFAAAIDVGYDMVKNGLKAKIEADLARYHGAQPSEAVPRA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ANM6_ARATH
Sequence: MQSGGDFSNGFHGDHHRELELEDKQGPSLSSFGRAKKRSHAGARDPRGGLANVLRVSDQLGEHKSLETSESSPPPCTDFDVAYFHSYAHVGIHEEMIKDRARTETYREAIMQHQSLIEGKVVVDVGCGTGILSIFCAQAGAKRVYAVDASDIAVQAKEVVKANGLSDKVIVLHGRVEDVEIDEEVDVIISEWMGYMLLYESMLGSVITARDRWLKPGGLILPSHATLYMAPISHPDRYSHSIDFWRNVYGIDMSAMMQLAKQCAFEEPSVESISGENVLTWPEVVKHIDCKTIKIQELDSVTARYKFNSMMRAPMHGFAFWFDVEFSGPASSPAKNTSETSIASGSSSISPSGEVNQKKRTNPSDALVLSTSPESPPTHWQQTIVYFYDPIDVEQDQVIEGSVTLSQSKENKRFMNIHLEYSSAGRSFVKESVMR
What is the function of this protein?
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA).
What are the official names of this protein?
Probable protein arginine N-methyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
Protein: TEX2_HUMAN
Sequence: MTSLYGRHAEKTTDMPKPSAPKVHVQRSVSRDTIAIHFSASGEEEEEEEEEFREYFEEGLDDQSIVTGLEAKEDLYLEPQVGHDPAGPAASPVLADGLSVSQAPAILPVSKNTVKLLESPVPAAQVLSTVPLAVSPGSSSSGPLASSPSVSSLSEQKTSSSSPLSSPSKSPILSSSASTSTLSSAKPFMSLVKSLSTEVEPKESPHPARHRHLMKTLVKSLSTDTSRQESDTVSYKPPDSKLNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKALSSSASELSNLSSLNGHLESNNNYSIKEEECDSEGDGYGSDSNIPRSDHPKSTGEPTREIELKSSQGSSLKDLGLKTSSLVLEKCSLSALVSKEDEEFCELYTEDFDLETEGESKVDKLSDIPLKPEVLAEDGVVLDSEDEVDSAVQHPELPVKTLGFFIMCVYVYLILPLPHYVSGLFLGIGLGFMTAVCVIWFFTPPSAHKYHKLHKNLRHWNTRSLDIKEPEILKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEAADQP
What is the function of this protein?
During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation.
What are the official names of this protein?
Testis-expressed protein 2, Transmembrane protein 96.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Note=Enriched at the nucleus- vacuole junction (PubMed:22250200). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity).
Protein: GPMA_METPE
Sequence: MYTLVLLRHGESAWNKENRFTGWTDVDLSPQGIEEAHRAATLLHDGGYSFDLAYTSVLKRAIRTLWIVLDDLDLMYLPVHHTWRLNERHYGALQGLDKRETTEKFGKDQVQAWRRGYAVRPPALEETDPRHPRFDPRYAGLKKDDLPATESLEDTLARVVPYWNETIVPTLQDGKRILIAAHGNSIRALVKYLDGVPDDVITGLNIPTGFPLVYELDDDLHPIRHYYLGDEEEIRRATESVASQTATKK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: COX3_OSPRO
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLLTSGLIMWFHFNSFLLVIIGLTCMLLTMYQWWRDIVREGTFQGHHTPVVQKGLRYGMVLFIVSEVFFFLGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSILLASGVSITWAHHSLMEGNRKQMIQALSITILLGIYFTILQASEYYESSFTISDGVYGSTFFVATGFHGLHVIIGTTFLIVCLLRQFNFHFTSTHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRPE3_HALMA
Sequence: MTEIRFSTDKESFIETARAAADGTRVPVEARVTVADPFEAYRRARDENTDGFYLETTGGQSGWGYFGIEPIERVEVSAGATPAQDGGSPSLEAIDDLLDREHLERGDCTVPYPCGAFGWLSYDVARELEDIPETTVSDGLPRLQFGVFDCIAAWEEPHDGNVEIHVTACPTVDGSPESAFERGRTMARELAQDAIHGEKHVQSQPTAASQATFESECGEAAFADRVRQIKQYVRDGDTFQTNVSHRLTAPAAVHPVDTFDAVRRVNPAPYSALLEFPGVDLVSASPELLLDVDGDQLLTEPIAGTRPRGATPSEDEDLEVDLCSDEKERAEHAMLVDLERNDLGKVSEYGSVDVAEYRRVDRYSEVMHLVSLIEGELRDAVSIADAVAAVFPGGTITGAPKPRTMEIIDEVERTRRGPYTGSIGMFGFDDRATLNITIRTLVHYDDEYRLRVGSGIVHDSVPEAEYRETLDKARALVTAVDEALGEQGSFAVESETEPMEGMR
What are the official names of this protein?
Anthranilate synthase component 1 3, Anthranilate synthase component I 3.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: RH45_ARATH
Sequence: MLEKSKSRKENDRKDRDRSKKENGRRDTTEMRSRVKRCDSEEEERIRIRRDRKSSDFEEEEYERDSKRRGEDKGRGRRERDRDRGKYLKRDRERREREKEKGRKKQKKERSREDCNEESDDVKCGLKRKRTERSRHGDDDVEKKTRDEQVEDEQKQLAEEVEKRRRRVQEWQELKRQNEEAQIESKGPETGKAWTLDGESDDEVKSDSEMDVDRDTKLENGGDAKMVASENETAVTVSENGGDRAADEDEIDPLDAFMNTMVLPEVEKLSNIVIDGILDFKMNGKETGDQAKKGFNKAALGRIIQGEDSDSDYSEPKSDDDPSLDEDDEEFMKRVKKTKAEKLSLVDHSKIEYEPFRKNFYIEVKDISRMTQDAVNAYRKELELKVHGKDVPRPIQFWHQTGLTSKILDTLKKLNYEKPMPIQAQALPIIMSGRDCIGVAKTGSGKTLGFVLPMLRHIKDQPPVEAGDGPIGLVMAPTRELVQQIYSDIRKFSKALGIICVPVYGGSGVAQQISELKRGTEIVVCTPGRMIDILCTSSGKITNLRRVTYLVMDEADRMFDMGFEPQITRIVQNIRPDRQTVLFSATFPRQVETLARKVLNKPVEIQVGGRSVVNKDITQLVEIRPESERFSRLLELLGEWYEKGKVLVFVRSQEKSISDFKSDVCNLLIATSVAARGLDVKELELVVNFDAPNHYEDYVHRVGRTGRAGRKGCAVTFISEDDAKYAPDLVKALELSEQPVPDDVKAVAEGFMAKVKQGIEQAHGTGYGGSGFKFNEEEDEVRKAAKKAQAKEYGFEEEKSDSEDENDVVRKAGGDISQQQITLAQIAAIASAASKAPVTANQLLPNGGGLATEPGIPPTDGAGRVAAMIAAANVQQYLAKIQADAIPEHYEAELEINDFPQNARWKVTHKETLGPISEWSGASITTRGKFYEAGRIPGPEERKLYLFVEGPTEISVKTAKAELKRVLEDITNQTFSLPGGAQSGRYSVL
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 45.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
Protein: AGRB_STAA9
Sequence: MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFFKILVTYSISIFLSVFLFTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILTFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYLSIIMYLLVLILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
What is the function of this protein?
Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP).  This quorum sensing system is responsible for the regulation of the expression of virulence factor genes.  Involved in the proteolytic processing of AgrD, the precursor of AIP.
What are the official names of this protein?
Accessory gene regulator protein B.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CA174_RAT
Sequence: MRSRKLTGGVRSSARLRARSCSSTSLASAGDIASSTSAKTTCLASSSHKATDRRTSKKFKYDKGHLLKAELQKVDPKSDISSLPKVVPVAPCENKFAEDGAEAAVPAPENTAPPQGCSKPVSEEPSVKAEEGLPTAPRSAAAAQETHDSSASQAEPVPVLQMDSSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDEDAEG
What are the official names of this protein?
UPF0688 protein C1orf174 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0688 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATAF_ASPTN
Sequence: MSLASLDLNALWLEHSAVIATLFAFGTALFLVSRSQKQSLNLPRFEVTNDVLKTIEEAHAQYPDDPFILSMVGMELAILPRSGIDVIKTLPEDQVSIKRHHHDVFLGEYTYMGTKSPEFDEAMRYDLTRNTPTVLASFVAEVQYAVEDSFGRPDQWTAFQPRACMSKIASLMSGRAFVGLPLSRDNTWVDATVRYTQDVTRAWLVLRTIPWVLRPFVAPFLPQVRSLKNQRRMTEERLTPLLDPSNAKNRDEIPGGDMLRWFRQRYPQGPTPKQLARDQLLATFASIYNLSNALSYLLFDLATYPEHIEPLRQELQEVLKGEPVNKENIQKLKKLDSFIRESQRLSPPSLANMPRIVTNPRGLKLPSGHTIPCGMRIMVRAHTLNLDPNLWPNPTRFDGFRFSKLREIPGNTFKYQHATTGTDNINFGHGLWACPGRHFASSQMKVVLAHLLLNYDIKLPNRMEKPQQQHFGLAIVPDTEQMVLLKIRG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of acetylaranotin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide-bridged cyclic dipeptide (PubMed:23586797).  The first step of acetylaranotin biosynthesis is performed by the NRPS ataP which produces diketopiperazine cyclo-L-Phe-L-Phe via the condensation of 2 phenylalanines (L-Phe) (PubMed:23586797).  The ataC domain of ataTC then catalyzes the formation of bishydroxylation of cyclo-L-Phe-L-Phe (PubMed:23586797).  The glutathione S-transferase domain ataG in ataIMG further catalyzes the conjugation of two glutathiones to the bishydroxylated intermediate (PubMed:23586797).  Next, the dipeptidase ataJ removes the Glu residues (PubMed:23586797).  The following step is performed by the carbon sulfur lyase domain ataI of ataIMG which may convert the bis-cysteinyl adduct to yield an epidithiol intermediate (PubMed:23586797).  The ataT domain from ataTC then catalyzes the oxidation of the free dithiols, followed by a cyclization step catalyzed by the cytochrome P450 ataF (PubMed:23586797).  AtaF probably acts as an epoxidase to promote a dual epoxidation formation at C8 and C9 along with C8' and C9', followed by the spontaneous nucleophilic attack of the amide nitrogens N10 and N10' to yield an intermediate with the pyrrolidine partial structure (PubMed:23586797).  The final steps of acetylaranotin biosynthesis involve the acetylation and ring rearrangement of an epitetrathiodiketopiperazine intermediate to produce acetylaranotin (PubMed:23586797).  AtaH probably catalyzes the acetylation of epitetrathiodiketopiperazine to produce a diacetate and ataY is responsible for the formation of the dihydrooxepin moiety that converts the diacetate intermediate to acetylaranotin via acetylapoaranotin (PubMed:23586797).  Both enzymes could function independently in the absence of the other (PubMed:23586797).  The acetylaranotin bis-thiomethyltransferase ataS located outside of acetylaranotin gene cluster is the main thiomethyltransferase responsible for converting acetylaranotin and its related intermediates to their methylated forms (PubMed:30096370).
What are the official names of this protein?
Cytochrome P450 monooxygenase ataF, Acetylaranotin biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TUSD_ECO55
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIAEGHELSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_YERPG
Sequence: MKQAFRVALGFLVLWASVLHAEVRIEITQGVDSARPIGVVPFKWMGPGTPPEEIGAIVGADLRNSGKFNPIDAARMPQQPSTAAEVTPAAWTALGIDAVVVGQVQPSADGSYVVSYQLVDTSGSAGSILAQNQYKVTKQWLRYSAHTVSDEVFEKLTGIKGAFRTRIAYVVKTNGGKFPHELRVSDYDGYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNGAPAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLAYTSDQGGRPQVYKVNINGGVPQRITWEGSQNQNADVSPDGKFLVLVSSNGGAQHIAKQDLETGAVQVLTDTLLDETPSIAPNGTMVIYSSTQGLGSVLQLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y1426_STRPM
Sequence: MDPKKIARINELAKKKKTVGLTGPEKVEQAKLREEYIEGYRRSVRHHIEGIKLVDEEGNDVTPEKLRQVQREKGLHGRSLDDPKS
What are the official names of this protein?
UPF0291 protein M28_Spy1426.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_SHIBS
Sequence: MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKDE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PSAA_CYCRE
Sequence: IVVEMDPIKTSFEKWAKPGHFSXTLXKGPNTTTWIWNLHADAHDFGSHTNDLEEISRKVFRAHFGQLAIILIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGSRGIQITSGLFQIWRASGITSELQLYCTAIGALIFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQLLDAGVDPKEIPLPHEFISNRDLLAQLYPSFAEGLTPLFTLNWSEYSEFLTFRGGLNPVTGGLWLTDTAHHHLAIAILFLIAGHMYRTNWGIGHSLKEILETHKGPFTGEGHKGLYEILTTSWHAQLALNLAMLGSLTIVVAHHMYSMPPYPYLAIDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTQYNNLLDRVLRHRDAIVSHLNWACIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWVQNTHALAPGSTAPDATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGMVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHXVWAFSLMFLFSGRGYWQELIESIVWAHNKLEVAPVIQPRALSIVQGRAVGVA
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SIA8A_XENTR
Sequence: MKLQGSRMWLCPRTRLPVGASALGFLILCWLYVFPGYRLPGHKEMVREVLRFGPGWRKNRTEMDSFRKLLQDCCDPPHLFSLTKVNTPLGENLWFDGEFFHSLTIDNSTRSLFPQDTPFKLPLKRCSVVGNGGILKNSRCGEQIDEADFVMRCNLPPLSREYTEDVGTRTQLVTVNPSIIDKRYQNLLWSRKSFVENLRVYQQSYVYMPAFSTKRGTDPSLRVYYTLADFGTNQTVLFANPNFLRNVGKFWKSRGIHSKRLSTGLFMVSAALSLCEEVTIYGFWPFQMDLGGRYISHHYYDNTLPLSGVHAMPEEFLQLWLLHKSGVLQMQLDQCKKDVSSQKPH
What is the function of this protein?
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (By similarity).  Glycosphingolipids are required for convergence extension movements during early development (By similarity).  Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (By similarity).  Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (By similarity).
What are the official names of this protein?
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase, Alpha-2,8-sialyltransferase 8A, Ganglioside GD3 synthase, Sialyltransferase 8A, SIAT8-A, Sialyltransferase St8Sia I, ST8SiaI.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SBNA_STAAC
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.