PharMolix/UniProtQA huggingface dataset:
Protein: PYRE_LACLM
Sequence: MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKTEFPEVEVIAGTATAGIPHGAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANSKFADADVKLATLTNYSELIEIAKETGYVTKEELELLKKFKENQETWQA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: KBAZ_ECOLU
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPVPLTDDIVAERAARLAKVAEETCREHFGEADLVYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLSAIWPRIIALVVQPGVEFDHTNVIDYQPVKATALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLENVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: DNAJ_CHLMU
Sequence: MDYYTILGVAKTATPEEIKKAYRKLAVKYHPDKNPGDAEAERRFKEVSEAYEVLGDAQKRESYDRYGKDGPFAGAGGFGGAGMGNMEDALRTFMGAFGGDFGGNGGGFFEGLFGGLGEAFGMRGGSEGARQGASKKVHITLSFEEAAKGVEKELLVSGYKSCDACSGSGAKTSKGVKVCDRCKGSGQVVQSRGFFSMASTCPDCSGEGRVITDPCSECRGQGRIKDKRSVHVNIPSGVDSGMRLKMEGYGDAGQNGAPAGDLYIFIDVEPHPVFERHGDDLVLELPIGFVDAALGIKKEIPTLLKEGTCRLNIPEGIQSGTVLKVRGQGFPNVHGKARGDLLVRISVETPQHLSNEQKELLRKFSETEKAENFPKKRSFLDKIKGFFSDFAV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTE_ECOL5
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQDPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMANDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: ROC1_SPIOL
Sequence: CVAQTSEWEQEGSTNAVLEGESDPEGAVSWGSETQVSDEGGVEGGQGFSEPPEEAKLFVGNLPYDVDSEKLAGIFDAAGVVEIAEVIYNRETDRSRGFGFVTMSTVEEAEKAVELLNGYDMDGRQLTVNKAAPRGSPERAPRGDFEPSCRVYVGNLPWDVDTSRLEQLFSEHGKVVSARVVSDRETGRSRGFGFVTMSSESEVNDAIAALDGQTLDGRAVRVNVAEERPRRAF
What is the function of this protein?
Probably involved in the 3'-end processing of chloroplast mRNA's.
What are the official names of this protein?
28 kDa ribonucleoprotein, chloroplastic, 28RNP.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RTXE_DROME
Sequence: MMPLRILVWNADGVSTKLPEVECFVRRHEIDVLLLSETHCKGAETPKLFGFVAYTANDPSGGNAKGGAAILIKNSLAHFPLTPIATAKVQLAPAVIETALGPISFGAVYCPPRFAWTTDEFKDILEEFQTKFIVAGDWNASHWLWGAGRSNQRGIALANLVLNSEVDSLATGGPTRYPYGCRGSPGYIDFALTKGVLGIHANISAVVELSSDHLPLVITLDAGAISYPKMERLITRRTNLEVFQSQLESTLPLNTAINSGQDVDDAIELLTNNIKSAARLATRSISRQPAADRIPIPREILLLIAEKRRLRTRWMRSRHPSDKTEWNRALSRLRCALVLHKAAWFDERLANTGVESEATHSLWKATRAIKRRCTRKAPLVDSNGTWCRTDLGQAEVFAAHLAERFQPFKLASLQQVEETQDQLNQALQMDMPITPFEPCEVAEVIVRQSNNKAPGHDVICNATLKALPRQAILYITLVFNAIVRLQYFPYQWKLGIISMIHKPGKPEREPASYRPISLLPSISKVFERLIAVRIVSIMEAQGITPEHQFGFRAGHCTVEQLHRVVEQILTAYDSKEYCNSLFLDIREAFDRVWHIGLQLKIKQTLPAPYFGLLKSYLEGRRFAVRFHSAISTEHNVAAGVPQGSVLGPLLYCLYSHDMPQPDVSLYGKSMLATFADDVCVTYRSRCEHDAADGIQDFAYRFSEWARRWNIGINSSKSNNVCFTLKRRTPPPVYIEEVPVPQPNAAKYLGVLLDRRLTFSKHVTDIRTRLRAKVAKHYWLLSSRSKLSLSNKLTIYKQILAPNWKYGCQIWGLACDSHIKRIQAIQNKVARLITGCEWFVRNTTLHRDLKLATVFDEINKHSSRYHDRLERHRNRLASALNRSRPPRRLNRRQPRDLITRSPLTRVRRS
What are the official names of this protein?
Probable RNA-directed DNA polymerase from transposon X-element, Reverse transcriptase.
Protein: CF195_HUMAN
Sequence: MIYPLDLFRNIPWKQGKCFASLSPEGERAFDGMEPLCQPGARPALRGLQHASDCYRLLSPPGSGLVGTNPSVPAPSPHCGCCQAWSISSFTFTGPTPFKINSDQATPCHLRSPETIFRQREISNEAF
What are the official names of this protein?
Uncharacterized protein encoded by LINC01600.
Protein: CAIT_ECO27
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TM88B_MOUSE
Sequence: MSEQERETEEDEGVASDTAPMLPRRRPTDYHISVLAPILATRGLGTLVLSGRALVGFLLHLLLPGTVFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALLSDRGSAALIVFGLLSLPPLVVLAAAARSLLVRRLRPALPDPARTPAPRRPPRSSGDLADGHPDEDKQLCAWV
What are the official names of this protein?
Transmembrane protein 88B.
What is the protein family that this protein belongs to?
Belongs to the TMEM88 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL2_ONYPE
Sequence: MAIKKYKPTTNGCRNMSVSAFSEITTQTPEKRLLVSHKDQAGRNNQGKITVRHRGGGVKRKYRLIDFKRNKDNIVGKVATIEYDPNRSANIALIHYLDGEKRYILAPKGLTVGMQIVSGKEADIKVANCLPLMNIPVGTTVHNIELKPGKGGQIARSAGSFCQIISREDKYVLLRLQSGEVRKVLGTCRATIGEIGNESYKLINYGKAGKKRFLGIRPTVRGSAMNPNDHPHGGGEGRAPIGRKSPMTPWGKKARGVKTRDRKKASNALIIRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MURD_BORBU
Sequence: MLLDEIKNLNFLIMGLGLNGGGVALSRFLLKRGAKLVITDLKSETELALSIDALRDFEDQIRYVLGKHDVNDFKNADIVVKNPGVKPNNKYLKFAKRIETDISLFLMFNKNPIVAVTGTKGKSTLVSLLYQALKEKYPGVKLGGNIGVSPLSFFDQLDGKSPLILELSSWQLQSLENFNPIISIITNVYNDHQNYYLNFDDYIIDKSKIFVNQTSGIVIIQDQAYCKYFSKFKSKVRVILFSEFNPCDFDQDIFYCNEGKVYFNDSLIGSFSNSRAVFIIPKVITFFVSYYLNIDLNRTGQILSNFKGIEHRLEFVKSVQNVMFYNDTASTIPESTVLSVKSLKTKDNRINLIVGGTDKELDFLSFSKIADIVRTWILIRGSATVKIIKILEKSSIQYFLFDSLRDAVNYAFKISSPGDIVLFSPASASFELFNNEFDRGLQFKNLVNNLG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_WOLSU
Sequence: MKKIPVGIVGVSGYTGLELLKMLLEHPYLELVYAANTEGGVRVGALHSSLQGVSDLSVEKADPKEAAKRCELLFLALPHQSAMEFAKEVLSLGKKVVDLSADYRLSLERYEAHYCPHLDKENLSHAVYGLIEWAREEIVQARLIANPGCYPTATLLGILPFIPYLDEDSSLFVDAKSGVSGAGKKLTHNTHYPTINENLFAYSPLSHRHEPEIAEKIELWGKKAKKVNFIPHLTPLTRGMLVSTFARLKEPVDAMAILRERYANEPFIRLRSSPVEIKAVAGTHFCDIYAMSQGRDLWVNSAIDNLLRGASSQAIANANLMLGLPEGAGLPRFAYAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_STRPM
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGIDWLQ
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELI_NPVAC
Sequence: MIDNILQFFLKNVPQDKTYEINNLQDANHLIIRNTRTGTRRLFEYVNNFQQFLNTIRNNFNGPCAKHDMGASCEDTEEPAEKHAAQTLDGHDWVLESNDFCIFVKPFILKKHYDIIQKYINFEDFFKSTDPGYINKCVQAGDYYYWPNWPKKQAFSFNGWQLFLNIKFGIVIEPTIPIIHNKKLGPVDLFVFDPKCFLNVELSLRTNHDPPQTLFVNGKTKFDDSHEDLFILKMADGTVATCKVNGELVNSDKNFFNYIRDDINLEECITVPKYKHIVNVNLKSLRVFENNNFDKNDVDLSDTRSRKPRIVPIISASSENADYIQTQINLGLIAIHENMVKVLATHERANDPNLLQQYFEKSKFKNFDFLIYVLWKILTKNENFSYRETDIKLFLELLCESLFACDKEALNEALKRCEPYKKQEKIVFNRACNHWFDFDDTKLCVSLGYYFGIHYMIYLTQSAKNEILDHDELWAYTYENVMALNLPPDIVCKGFFRKLENVVTGVNLVFNGKHYQIVKKEDDLFKLTKSNCYKLSNIKFNNWKYLYLTTHGVYNVFTNSFHSSCPFLLGTTLPQTFKKPTDEKYLPEDAFNYMLSTSADELSIYRTYHIAKMCRDVKMLKTNTAIVNYMGNCNTCQADMRVALNNLFRDLWNLDDENLITLALYVNKNRVSDMLHNLKCKPCRSTVSGSRPKCKCYKKIKINRKALKVCLMADMFGNDAELSELIWMLIFTNKTYVSTTLIRTNSEFVNQHGEFFSKEHNKIIQYLYRTIHKIEYVDMLMDKFNDKRLFLTELRDDVAREPDVQFEESDNISKFYTHHADALMILKKYNVWWDKIILARSTDDLPTWLTRFYMRIIMSKVDLKEYSYNYLKKIVEGYLYFKRFTNFNHANAIMLMHFAASLAIPVDYGKKAIYMPGEPGSGKSSFFELLDYLVLMHKFDDDNHSGESNKETSDKEVSKLNSQLYTINELKQCSESYFKKHADSSKSDSKSRKYQGLLKYEANYKMLIVNNKPLYVDDYDDGVQDRFLIVYTNHKFVDSVKFAGSVYEHIKSKQFPIESMYYESLVTPVRLFLSHVLMYRRDPKTGFVVYKTLLSNDPMHKHNLMCLSTNNSPLYALIYILNIKTVRSATITIGEDKMEEMIGIAVQHFKNFLHPSFVQYNYKKNINASSSKSFVFNEQVLLQQIKNKFKNNYNKTTNVFYNMTMALNRNDLNTSVPNFVC
What is the function of this protein?
Essential for initiation of viral DNA replication, it may contribute to other functions such as controlling the switch to the late phase and leading to the inhibition of host protein synthesis.  Required for late and very late gene expression.
What are the official names of this protein?
DNA replication helicase, P143.
What are the subcellular locations of this protein?
Host nucleus. Note=LEF-3 is responsible for transporting the helicase to the host nucleus.
Protein: LANC3_DROPS
Sequence: MERRYLKNPFQDFIGGENTAFASDEEHIKNLICTYVDTILEHCHPNSDDEDDRGDLYVGNAGIAFMFWKLASCEQTRDLYPPALQHASAFIRNAKANAERFKKRSAERYSFLCGNAGIYAVSAAISQAVKDTEELSNDLANFKSGIPSSKEFIHTKNGCDEVLVGRAGYLSGCYWLNDVLPDKKITDDDLISICQLIVTSGREYSKMNNSPLPLMFQYHGTEYLGAAHGLCAILHMLLDSPWFRTVPISAPAAELREIKRSIDYFLVLQDAEGNFPVALEDLRSGRDKRLVHWCHGAPGAVYMLAKAYLIFKEEKYLTSLRRSADLVWKKGFLRKGPGICHGVAGNGYVFLLLFRLTNEMKYLYRAHKFMELLTNSEFKQRARIPDNPHSLYEGVAGTVCFLVDILEPEQAYFPFMDVFH
What are the official names of this protein?
LanC-like protein 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the LanC-like protein family.
Protein: YCIB_POLNA
Sequence: MKILFDFLPIALFFGMFKYAEGHKDWAAGLATDWLGFMVSGGVVGPAEAPVLLATVVVIVATLAQILWLKARGRKVDTMLWVSLALVTALGSATIYFHSESFIKWKPTVLYWVMGASLLVGELVFKKNGIKSLMGAQMSLPDAVWRKVNFSWVAFFAAMGCLNLWVAFNFPTSTWVNFKLFGGMGLMLVFVLAQAFFLNKHIKPDTTS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KTNA1_HUMAN
Sequence: MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC
What is the function of this protein?
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner.  Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.  Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.  Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins.  This transport is required for axonal growth.
What are the official names of this protein?
Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic (PubMed:9658175). Localized diffusely in the cytoplasm during the interphase (PubMed:10751153). During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region (PubMed:19261606). Also localized to the interphase centrosome and the mitotic spindle poles (By similarity). Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 (PubMed:10751153). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214).
Protein: MUTS_GLOVI
Sequence: MADPATQLSQWDFRRFARSDLTPMLQQYVEVKAQHPHCLLLYRMGDFYETFLADAEIVSRELEIVLTGRQAGDKIGRIPMAGIPHHALERYCAQLIEKGYAVVICDQVESPEQAKERARQAKVARRSKSDGDAPLLPLLLEDGEQIDWEGAESVLVRRAVTRVLTPGTVLEDQLLVGRRNNYLAALVQAGECWGLAFADISTGEFQVTQLESAEALVQELLRLQPAEVLLSGDAPDPLVLLRPGEASSERPECLPSQFCYTLRPRRYFELDEARRLLMETFGVRSLEGFGCENLPLAVRAAGGLVQHLLETQRGVSIPLEGIRTYTLSQYLILDHQTRRNLELTQTVRDGAQYGSLLWALDRTRTVMGGRALRRWLLQPLLDTRAIGRRQDSVAELYDEGLLRERLQRILESVYDLERLAGRCGSGTANARDLVALGESLLKLPALAEAVAASTSPYLKALQSIPVELERLGEKLRRTLVDTPPLILTEGGLIRAGVHPELEGMRGQLIEDRDWLVDLEARERARTGIQTLKVGFNKAFGYYLSISRGKAEKAPPEYLRKQTLTNEERYITPELKERETRILNAQQQTNQLEYDIFNILRQEAGRHVSALRQVARRVAALDALAGLAEVAVYHDYCRPVLGEGREVHIEAGRHPVIEQAIPAGFFVPNDARMGAEAEPDLIILTGPNMSGKSSFIRQVALIQLLAQVGAFVPARGAVLGVADRIFTRVGAVDDLATGQSTFMVEMTETANILNHATPRSLVLLDEIGRGTATFDGLAIAWAVAEYLASHIRCRTIFATHYHELNELASVVSGVANYQVTVQELADRIVFLHRVTPGGADRSYGIEVGRLAGLPPSVVARARTVLAQVEQHSQIAVGLRDSNGSASESAAG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: MYO5_CANAL
Sequence: MAIVKRGGRTKTKQQQVPAKSSGGGSSGGIKKAEFDITKKKEVGVSDLTLLSKITDEAINENLHKRFMNDTIYTYIGHVLISVNPFRDLGIYTLENLNKYKGRNRLEVPPHVFAIAESMYYNLKSYGENQCVIISGESGAGKTEAAKQIMQYIANVSVNQDNVEISKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFSEGNYQPIAAHITNYLLEKQRVVSQITNERNFHIFYQFTKHCPPQYQQMFGIQGPETYVYTSAAKCINVDGVDDAKDFQDTLNAMKIIGLTQQEQDNIFRMLASILWIGNISFVEDENGNAAIRDDSVTNFAAYLLDVNPEILKKAIIERTIETSHGMRRGSTYHSPLNIVQATAVRDALAKGIYNNLFEWIVERVNISLAGSQQQSSKSIGILDIYGFEIFERNSFEQICINYVNEKLQQIFIQLTLKAEQDEYVQEQIKWTPIDYFNNKVVCDLIEATRPQPGLFAALNDSIKTAHADSEAADQVFAQRLSMVGASNRHFEDRRGKFIIKHYAGDVTYDVAGMTDKNKDAMLRDLLELVSTSQNSFINQVLFPPDLLAQLTDSRKRPETASDKIKKSANILVDTLSQCTPSYIRTIKPNQTKKPRDYDNQQVLHQIKYLGLKENVRIRRAGFAYRSTFERFVQRFYLLSPATGYAGDYIWRGDDISAVKEILKSCHIPPSEYQLGTTKVFIKTPETLFALEDMRDKYWHNMAARIQRAWRRYVKRKEDAAKTIQNAWRIKKHGNQFEQFRDYGNGLLQGRKERRRMSMLGSRAFMGDYLGCNYKSGYGRFIINQVGINESVIFSSKGEILLSKFGRSSKRLPRIFIVTKTSIYIIAEVLVEKRLQLQKEFTIPISGINYLGLSTFQDNWVAISLHSPTPTTPDVFINLDFKTELVAQLKKLNPGITIKIGPTIEYQKKPGKFHTVKFIIGAGPEIPNNGDHYKSGTVSVKQGLPASSKNPKRPRGVSSKVDYSKYYNRGAARKTAAAAQATPRYNQPTPVANSGYSAQPAYPIPQQPQQYQPQQSQQQTPYPTQSSIPSVNQNQSRQPQRKVPPPAPSLQVSAAQAALGKSPTQQRQTPAHNPVASPNRPASTTIATTTSHTSRPVKKTAPAPPVKKTAPPPPPPTLVKPKFPTYKAMFDYDGSVAGSIPLVKDTVYYVTQVNGKWGLVKTMDETKEGWSPIDYLKECSPNETQKSAPPPPPPPPAATASAGANGASNPISTTTSTNTTTSSHTTNATSNGSLGNGLADALKAKKQEETTLAGSLADALKKRQGATRDSDDEEEEDDDDW
What is the function of this protein?
Type-I myosin implicated in the organization of the actin cytoskeleton.  Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis.  At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly.  Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).  Plays a role in chitin deposition in the cell wall, in determination of the budding pattern, and is required for hyphae formation.
What are the official names of this protein?
Myosin-5, Class I unconventional myosin MYO5, Type I myosin MYO5.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing bud tip, the mother-bud neck after cytokinesis, and the hyphal tip.
Protein: NTRYL_RICBR
Sequence: MPKLKIFLFKYLYSKRFIGILVAIAIIFSYFTYYTISIGTKNGAVNSSKVIWFLLIDLIIFLVLGILLTRKFFQSFFFKNSDQNTSKLQNRIVVAFSLAAAIPTIIVSISSAYFLNLSIQAWFDRKISVVLDQSIMVADSYIAEHKVLLRETALAVAEDLSDMYYDLIHNPALFTKTLNTEAEMRSLDEAIVLNKSTNTIIANSYLSFSLSFATIPAHLIKKADSCEPVEVKSDPTKIRMLIKLKEYNDVYLLVGRSIDNKIIDHIDATNGAAAEYHRLKNQIGNIQIKFSIIFIFIALLLLLIAISFGVIVTAKIVNPIKKLVIATDKVKSGDLTVQVPENEVDKDEIGTLYAAFNRMIKQLSRQQRDLVIAQRALAWSDVAKKVAHEIKNPLTPILLASERLLKKFSPEIKERAEFENYLKMIIRHTNDIKNIVSEFVLFARLPAPKFTNCDLIYVINNIVEARKLLNNNILYSFETNIDQFDFTCDTTQINQVMINLLKNAEESLEGSNQAAIKVNINTSEQFINITVLDNGRGFPPELIGKATESYVTTRSKGMGVGLAIVKRIVEEHCGVLDIANRETGGAVIDIRFNLEELKLKVKRHEIGVIS
What is the function of this protein?
Member of the two-component regulatory system RBE_0470/RBE_0312.
What are the official names of this protein?
Putative sensor histidine kinase NtrY-like.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSRA_LACE2
Sequence: MLALSRKKDEAIIINDDIEITIIEIKGDQVKLGISAPKSVPIYRKEVYAQILDSNKEAASSVDVKTLNQLFKK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF205_ASFK5
Sequence: MVEPREQFFQDLLSAVDKQMDTVKNDIIDVMKEKTSFLVSFENFMERYDTMEKNIQDLQNKYEEMANNLVAVMADTKIQLGAIIAQLEIIMVNGTPLPAKKTTMKDATSLPPPNPNNEQSVFTNGSPTSGKIGETVKKNLTNAMFFTRSEWASSEPFRQKFLTPEIQAILDEQFANKTGIERLHAEGLYMWRTQFSDEQKKMVKEMMKK
What is the function of this protein?
Induces host endoplasmic reticulum stress and consequently activates autophagy and NF-kappa-B signaling pathway.  In turn, may induce autophagy-mediated STING1 degradation and innate immune evasion.
What are the official names of this protein?
Uncharacterized protein K205R, pK205R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus K205R family.
Protein: DPO4_PASMU
Sequence: MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTAQAFKLCPNLILLPVNMPLYKQVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSATWIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNGQFVIKPEQIEHFIANLPLKKIPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRILKSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHVTTLEKRGMLITLNSFELLLTQIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_BRUA4
Sequence: MRTYLDLLQHVLDNGTDRGDRTGTGTRSVFGYQMRFNLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVSIWDEWADKNGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHGNPNSRRLIVSAWNPALVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVAGLKPGEFIHTLGDAHIYANHFDQARLQLTRIPKKLPTMWINPDVKDLFAFRFEDFQLEGYEADPTIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_LISMF
Sequence: MYAIIETGGKQIKVEAGQEIYVEKLAGEVGDVVTFDKVLFVGGDSAKVGVPFVEGATVTAKVEKQGRAKKLTVYKYKPKKNYHKKQGHRQPYTKLTIDAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.