PharMolix/UniProtQA huggingface dataset:
Protein: CENPH_YEAST
Sequence: MTNSSEKQWERIQQLEKEHVEVYRELLITLDRLYLIRKHNHAVILSHTQQRLLEIRHQLQINLEKTALLIRLLEKPDNTNVLFTKLQNLLEESNSLDYELLQSLGAQSSLHKQLIESRAERDELMSKLIELSSKFPKPTIPPDDSDTAGKQVEVEKENETIQELMIALQIHSGYTNISYTI
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit MCM16, CENP-H homolog, Constitutive centromere-associated network protein MCM16, Minichromosome maintenance protein 16.
What is the protein family that this protein belongs to?
Belongs to the CENP-H/MCM16 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: RL4_GEOSW
Sequence: MPKVALYNQSGETIGEIELNDSVFGIEPNKHVLFEAVIMQRASLRQGTHKTKNRAEVSGGGRKPWRQKGTGRARQGSIRAPQWRGGGTVFGPVPRSYSYKLPKKVRRLAIKSALSSKVLENNIVVLDNLTLEAPKTKEMVKILNNLSVDRKALIVTDDVNENVTLSARNIPGVTVVTANGINVLDVLNHDKLVITKAAVEKVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: SUB6_TRITO
Sequence: MGFITKAIPIVLAALSTVNGAKILEAGPHAETIPNKYIVVMKREVSDEAFSAHTTWLSQNLNRRVMRRSGSSKAMAGMQDKYSLGGIFRAYSGEFDDAMIKDISSHDDVDYIEPDFVVRTSTNGTNLTRQDNVPSWGLARVSSKKAGGTTYYYDSSAGKGVTAYVIDTGIDINHEDFRGRAKWGKNFVDDMDEDCNGHGTHVAGTVGGTKYGLAKGVSLVAVKVLDCEGSGSNSGVIKGMEWAMREASGGGNGTAKAAGKAVMNMSLGGTRSQASNQAAKAISDAGIFMAVAAGNENMDAQHSSPASEPSVCTVAASTEDDGKADFSNYGQLVDVYAPGKDITSLKPGGSTDTLSGTSMASPHVCGLGAYLIGLGKQGGPGLCDTIKEMAHDAIQRPGEGTTSKLIYNGSGK
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDSGA_PSEPU
Sequence: MLKRQSAPLGTWLMSASASTAEALGYAGFDWLLVDMEHVPIEFRDLWHILQAIQCTGAQPIVRVAANDPVLLKRALDLGSTNVMVPFVENAEQARAAVSAVKYPPMGTRGFAAVHRASRYGTWKGYGQQANDSVSCILQIETATALANLEEIAAVPGVDALFLGPGDLSSVCGHIGNPAHPDIQAMISDAIVRCKAIGMPIGIVGGTPELVGSYLEQGYAFAAVASDMAMMMSKANELLVALKGRQAPEAVATAY
What is the function of this protein?
Catalyzes the retro-aldol cleavage of 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate to (2S)-3-sulfolactaldehyde and pyruvate.  Is involved in a degradation pathway of sulfoquinovose (SQ) that allows P. putida SQ1 to use SQ as the sole carbon and energy source for growth.
What are the official names of this protein?
2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase, 2-keto-3,6-dideoxy-6-sulfogluconate aldolase, KDSG aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: ZN718_HUMAN
Sequence: MELLTFKDVAIEFSPEEWKCLDTSQQNLYRDVMLENYRNLVSLGVSISNPDLVTSLEQRKEPYNLKIHETAARPPAVCSHFTQNLWTVQGIEDSFHKLIPKGHEKRGHENLRKTCKSINECKVQKGGYNRINQCLLTTQKKTIQSNICVKVFHKFSNSNKDKIRYTGDKTFKCKECGKSFHVLSRLTQHKRIHTGENPYTCEECGKAFNWSSILTKHKRIHAREKFYKCEECGKGFTRSSHLTKHKRIHTGEKPYICEKCGKAFNQSSTLNLHKRIHSAQKYYKCEECGKAFKWSSSLNEHKRIHAGEKPFSCEECGNVFTTSSDFAKHKRIHTGEKPYKCEECGKSFNRSTTLTTHKRIHTGEKPYTCEECGKAFNWSSTLNVHKRIHSGKNPYKCEDCGKAFKVFANLHNHKKIHTGEKPYICKQCGKAFKQSSHLNKHKKIHTVDKPYKCKECGKAFKQYSNLPQHKRTHTGGKF
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 718.
What are the subcellular locations of this protein?
Nucleus.
Protein: YR450_MIMIV
Sequence: MNKKIEKNNNVINKPNKYESNTTDNQLIMKKNANSGSKKSRSTKVEVETNLPKRRGRRPKKILDSFESTTNVLNTSTEQNNSAVILRLPKIDPSKLSGLKNKQGRKVFEVPETTEPGDNYSDNELSEGMFRNDIPKDDVCHKCIKYEKEITHLKNEVMKLKNCDKTDKTSKIHNTSVTFISLGSGKKMSLKKTNLRCLWDCHKFDNIPCYLPELYNNGKYYVIASVFCSFNCALAHNLYYIKDSKIDIRKSLVFRLYRELYGLTPDEPIELKEAPPKELLEDFGGKVNIIDYRRSFIKLNKEFIVYMPPLKPIGVQIVEHDTDTDGNDTDRDYVLKRNKPLMKGRGIVSMMGFNK
What are the official names of this protein?
Uncharacterized protein R450.
Protein: CYB_SUSVE
Sequence: MTNIRKSHPLMKIINNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGLYYGSYMFLETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVITALAAVHLLFLHETGSNNPTGIPSDMDKIPFHPYYTIKDILGALFMMLILLILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLAVVTSILILILMPMLHTSKQRSMMFRPVSQCLFWMVVADLITLTWIGGQPVEHPLIIIGQLASILYFLIILVLMPITSIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MAL2_MOUSE
Sequence: MSAGGAVPPPPNPAVSFPAPRVTLPAGPDILRTYSGAFVCLEIVLGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGLFLSGMVTQIDANWNFLDFVYHFIVFVFYFGAFLLEAAATSLHDLQCNTTMTVKPLLNDNQYNINVAATVFAFMTTACYGCSLGLALRRWRP
What is the function of this protein?
Member of the machinery of polarized transport.  Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity).
What are the official names of this protein?
Protein MAL2.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface (By similarity).
Protein: TPIS_MESH2
Sequence: MKKIIIGNWKMNKTVSETRDFIQKFDIFYQENVGKIKEDLDFAIAPSFISLSLISKSLTKKLEIAAQNLSQFDSGAFTGEISGKMLQDLGTKYVIIGHSERREIFKEKDEELKNKILQAQKYDLIPVFCVGESLLEFEAGLTKKVIISQINAIKSVLNFQKAIIAYEPIWAIGTGKTATAAIAEKVCGLIKENFGKNTMVIYGGSVNSKNINELVSQKSIDGALVGGASLDPEEFGKILVNS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_MYCBO
Sequence: MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHMDVIRQRALDCGAVEAVVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEVIVGFERGVPVSVDGKPVSMLAAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEHVSGEVRLVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAARGFVYVHGLSSKLAARRDLR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_ACTPJ
Sequence: MTTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPGLVFEGVVDLGIIGENVLEEEELGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQDFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPSAGLADAICDLVSSGATLEANGLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKEITALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROP1_MOUSE
Sequence: MPQTDKQVCIPPELPELLKQFTKDAIRTQPPDLIQWAAEYFGAMSRGEIPPVRERSEQIPLSNWAELTPELLKVLHSRVAGRLIIHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE
What is the function of this protein?
Important for male fertility.  With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
What are the official names of this protein?
Ropporin-1, Rhophilin-associated 'oppo' protein, Rhophilin-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the ropporin family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
Protein: COX1_SOYBN
Sequence: MTNPVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGSGNWSVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDSAISSLHLSGVSSILGSINFITTISNMRGPGMTMHRSPLFVWSVPVTAFPLLLSLPVLAGAITMLLTDRNFNTTFSDPAGGGDPILYQHLFRFFGHPEVYIPILPGSGIISHIVSTFSGKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFHYWVGKIFGRTYPETLGQIHFWITFFGVNLTLFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGIRRFFVVVTITSSSGNNITRANIPWAVEQNSTTLEWLVQSPPAFHTFGELPAIKETKSYVK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RISB_ECO45
Sequence: MNIIEANVATPDARVAITIARFNNFINDSLLEGAIDALKRIGQVKDENITIVWVPGAYELPLAAGALAKTGKYDAVIALGTVIRGGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MTAP_SYNY3
Sequence: MGMIISMAMTAVTIWTKTKPGRVSCFIRKNSTMVNAPIGIIGGSGLYQMEALKNVEEVTLDTPFGAPSDSFIVGELAGVRVAFLARHGRGHHLLPSEIPFRANIHGMKQLGVKYLISASAVGSLQAEAKPLDMVVPDQFIDRTRQRISTFFGEGIVAHIGFGNPICPQLAQCLSTAIAGLELEGVTLHDRGTYVSMEGPAFSTIAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPDHDHVTVEMVIGNLQKNAVNAQQVILETVKQLAANPFESIAHRALQYAVLTPPDKFPAATYEKLSLLLGKYYPPAP
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: GUF1_THEAN
Sequence: MLYKYLFIYIVTKISLSSSLYHNFCTINNTNGSNFNVFDTNNGRFLNKNNRIRNILNKNINKKSSFSFINGNSLKNFKNDHKYHDFTKFTKIPEFLEEDNEPIVSELIRNFCIIAHVDHGKSTLADRFLEFTKSVPPERLKEQYLDNMELERERGITIKLQSARIKYNSILDGKTYTLNLIDTPGHIDFNHEARRSISACEGAILVVDGTKGIEAQTVTTANIAIEKGLKIIPVVNKIDLEHCDFKSTAESLKKFFGFKESDILKASAKKGIGIEDILEAVVVSIPPPKVDLEKPFRALVFDSFYDPYRGAICYIRVCCVFRLYFQVFEGSTKIGDEITLMNADITSKVTGLGIMLPEMKQTHSLQLVNSSGQVGWITAGIKKTNEIHVGDTISLKSYVKKNLVEPINKFENSKPTVFAGIYPCIGGDFDKLQTALEKLKLNDHSFQFERSDSSMVGMGFKCGFNGLLHLDITVERLEREFDTQVIVTSPSVPYRCTLRDKSVVTVDDASKWPDESQIKSSEEPWTDVTLRVPEEYFLSFINIILSSVGSVMSMLSKMRGRFKEKNKVKDTNMVVMNYDLPLSEILSDFFNKLKSVTNGYGSYDYEGTFYEPIELCKLKILLNGTEAKGLAVVTPRNRAYDRGKLIVETLVNLIPSRQFKVPVQAVIGKRVISSSNIPAVKKNVIEKCSGGDPSRKKKLLENQARVLLVLINDVIGKETNGSGRMCNNPF
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1 homolog, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: Y893_BACAC
Sequence: MPIWLGILVGVVALVAGVALGFFIARKYMMNYLQKNPPINEQMLKMMMMQMGQKPSQKKINQMMSAMNKQQMK
What are the official names of this protein?
UPF0154 protein BAMEG_0893.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PCP_CLOP1
Sequence: MKVLITGFDPFGGESINPALEAVKMIPENIEGAQVIKLEIPTVFRKSLEKIEEKIEEINPDVVISIGQAGGRFGVTPERVAINMDDARIEDNEGNQPIDISIYEDGESAYFSNLPIKAMVKEMVDNGIPASVSNTAGTFVCNHVMYGVLYLVNKKYKNIRAGFIHVPYIPTQVVNKPNTPSMSINDIAKGLELSIKAIVLNDNDIKTVGGAVC
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_METC4
Sequence: MSHDSEPQPVTATPGGPLNGSLKPPGDKSISHRAMILGLLAIGETQVEGLLEGDDVLRTAAAAKALGAQITREGEGRWRIVGVGIGGMQDPDGVLDFGNAGTGSRLMMGVVGGQPVTATFDGDASLRKRPMRRILDPILKMGAEIVSEAEGGRVPLTLRGPREAIPIRYELPVASAQIKSAVLLAGLNAPGTTTVIEKAASRDHTERMLHLFGAEVTVTPSGEGGHGRTVTLTGQPTLRGTDVVVPADPSSAAFPLVAALIVPGSEVILRGVMMNPLRTGLITTLIEMGADIERLDEREEGGETVADLRVRASRLKGVDVPAERAPSMIDEYPILAVAASFAEGTTRMNGLHELRVKESDRLAAVAAGLAANGVTHAIEGDDLIVTGNGQAPAGGGTVATHLDHRIAMAFLVLGLAAKSPVTVDDGAMIATSFPSFRPTMLALGARIEDGAAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_BACP2
Sequence: MKLELFDFDLPERLIAQVPLEKRDASRLMVLNKQTGEVTHDTFSQITDYFQTGDCLVLNNTRVLPARLFGMKEDTGAKVELLLLKQEEGDKWETLVKPAKRVKKGTVITFGDGRLQAVCTEELEHGGRKVEFQYTGIFYEVLESLGEMPLPPYIKEQLDDRERYQTVYSKEVGSAAAPTAGLHFTNELLDALKEKGVHIAFITLHVGLGTFRPVSADRIEEHEMHAEFYEMNEETAAELNRVRKEGGRIISVGTTSTRTLETIASAHDGEFKASSGWTSIFIYPGYTFKAIDGMITNFHLPKSSLIMLVSALAGREHVLKAYNEAVKEEYRFFSFGDAMLIQ
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR1_PHOPR
Sequence: MSNVLVLKSSILGDYSQSNGLIDHLVSSWGDSVSSVIERDLVATPIPVLDGEIAGGLRGGDTLTARQEEALALSDMLINELQNSDTIVIAAPMYNFSVPTQLKNWFDIIARAGVTFSYTENGPVGLITGKKVIVVTTRGGMHKDGPTDTMVPYLKTILGFIGLTDVEFVYGEALAMGEEMAAKGITNAKSALEKISA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: NRX1B_CHICK
Sequence: MGGFLRGSPEPGPAGGSGGSAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYTWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSTGLGDYLELHIHQGKIGVKFNVGTDDIAIEEINAIINDGKYHVVRFTRSGGNATLQVDNWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIKIGGKERGHPFQGQLSGLYYNGLKVLNMAAENDANIVIEGNVRLVGEVPSSMTTESTATAMQSEMSTSVMETTTTLATSTARRGKAPTKEPIGQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGGREYPGSSEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVIKEKQPNSAKSSNKNKKNKDKEYYV
What is the function of this protein?
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins.  May play a role in formation or maintenance of synaptic junctions.  May mediate intracellular signaling (By similarity).  Plays a role in angiogenesis.
What are the official names of this protein?
Neurexin-1-beta, Neurexin I-beta.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ATPE_STRP6
Sequence: MTQMTVQVVTPDGIKYDHHAKCISVTTPDGEMGILPNHINLIAPLQVHEMKIRRGGEDEKVDWIAINGGIIEIKDNVVTVVADSAERDRDIDVSRAERAKLRAEREIAQAETTHNIDEVRRAKVALRRALNRINVSKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MTNN_ECOK1
Sequence: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: ALLS_SALCH
Sequence: MFDPETLRTFISVAETGSFSKAAERLCKTTATISYRIKLLEENTGVGLFFRTTRSVSLTAAGSHLLSQAKDWLAWLDSMPDELRQVNDGVERQVNIVVNNLLYSPQAVASLLSWLNARYPFTQFHFSRQIYMGVWDSLLYEGFSLAIGVTGTEPLANTFMLDPLGSVQWRFLMSADHPLAHVSGPLTEAQLRRFPAINIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFVPQPLCQTLIDKNELVSCTIPTMRPPSPLSLAWHKFGGGKAVEDIVKLFTQRQPEIAGFLSIFNTVRCEKSSHFANWRVK
What is the function of this protein?
Positive regulator essential for the expression of allD operon.  Binds to the allD promoter (By similarity).
What are the official names of this protein?
HTH-type transcriptional activator AllS.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: FEN_METBF
Sequence: MGTDIGDLLQKRKIELSDLTNQVVAIDAFNTLHQFLSIIRQRDGNPLVNSRGKVTSHLSGLLYRTASLIEVGIKPVFIFDGKPPDLKSETLNRRKEVRESSLEKWENAKVEGDLEAAYKYAQASSKVDQEIVEDSKYLLSIMGIPWIQAPCEGEAQAAHMVLKKDADYVASQDYDSFLFGAPTVIRNLAVTGKRKLPGKHVYVDVELELIELEETLGVLGINREQLIDIAICVGTDFNKGLEKVGPKTALKLIKKHGDIHAVLREKGVEIKELDRIRELFTHPDVTDDYEIKWGKPDSEKLIKFLCKENDFSVDRVKKAVERLKVVSRGRQQTLDQWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.