PharMolix/UniProtQA huggingface dataset:
Protein: NCAP_PUUMG
Sequence: MSDLTDIQEEITRHEQQLVVARQKLKDAERAVEVDPDDVNKSTLQARQQTVSALEDKLADYKRRMADAVSRKKMDTKPTDPTGIEPDDHLKERSSLRYGNVLDVNAIDIEEPSGQTADWYTIGVYVIGFTIPIILKALYMLSTRGRQTVKENKGTRIRFKDDTSFEDINGIRRPKHLYVSMPTAQSTMKAEELTPGRFRTIVCGLFPTQIQVRNIMSPVMGVIGFSFFVKDWPEKIREFMEKECPFIKPEVKPGTPAQEVEFLKRNRVYFMTRQDVLDKNHVADIDKLIDYAASGDPTSPDDIESPNAPWVFACAPDRCPPTCIYVAGMAELGAFFSILQDMRNTIMASKTVGTAEEKLKKKSSFYQSYLRRTQSMGIQLDQRIILLYMLEWGREMVDHFHLGDDMDPELRGLAQSLIDQKVKEISNQEPLKI
What is the function of this protein?
Encapsidates the genome protecting it from nucleases (Probable).  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable).  The nucleocapsid has a left-handed helical structure (By similarity).  As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (By similarity).  Involved in the transcription and replication initiation of vRNA by mediating primer annealing (By similarity).  Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (By similarity).  Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (By similarity).  Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (By similarity).  Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity).  Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity).  Also displays sequence-unspecific DNA endonuclease activity (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the hantavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host Golgi apparatus, host cis-Golgi network. Note=Internal protein of virus particle.
Protein: RR12_EIMTE
Sequence: MLTFNQLIKNSRKKKNKFKNSILNRCPQKKGICLKVFTKSPKKPNSALRKVVKIRLSNNKEIIAYIPGEGYAIQEHNYALIKGGKVQDLPGIRYKIIRGALNVSGVKNRKSSRSKYGTKK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
Apicoplast 30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, apicoplast.
Protein: RSMA_JANSC
Sequence: MVAIDGLPPLRDVIAAHGLSARKALGQNFLLDLNLTAKIARLAGDLTSVDVLEVGPGPGGLTRGLLAEGARRVVAVEKDPRCLPVLAEIEAIYPGRLKVLNADALELDWAADLQAPRKIVANLPYNVGTELLVRWLTPASWPPPWESLTLMFQREVAERIVAQPGSKTYGRLAILSQWRADPRIVMGLPPEAFTPPPKVHSAVVHFTALPAPRFPADARVLTRVVAAAFGQRRKMLRAALKGLAPDIEDRLVAAGLKPTDRAEQVPLEGFCALARVMEDVITPSHGREA
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALR1_MOUSE
Sequence: MFLPKAAVSAFSMHGSLCFLWTVCLSISPLSQQGVQAFQCSNGVSLPSDYVCDFTDHCGDNSEEQQCWSYGRCNFEDRLCSMTEDQTLQPGWTRRSGIISNSPPFWDHNGNISAHFLALVSRVDSISSNLRSRIFLPTNDQQVCQITFYNFSSNQNGKLIAGLQTLCGDPIEHLWQKTEILQSRWERNVITVQSSQQFQVIFQAQMLATHGQEEVIAIDDISFSSGCLPADVCQTCGFDLDTCGLATEASAGRTSWMCTKVREIPSLDSVPWQDQRGHDEGSFVWMRAGHASVSRLVESSAYLNSSVCHCMDGNCRLQFNYTMENSILRVRLYNDKEEKKTWTFNTSTYSTWMKADVLIPEDLKAFKVVLEGTVLSQKSFIGIDQLLVYNFGQTHSQKLCSVNEYTPASRQCLTHSSVCDSGMDHSNGIDEDSEACASLLTWDFESGFCGWEPFPTEDSHWEVVRGLSNGEHLFLEAGHTVSRNQGSFIYFGPQKSTAVARLGSPILTKSLTTFTPCQVRFWYHLSEHSSLSVFTRTSVDGSLLKQSEVTQFSDSQWSQAKVDLHAKAEESTLPFQLVLEATILSSNATVAVDDISISHECEISYKSLRSTSIQNKVADCDFEANSCGWFEASGGDHFDWVWSSQSNLSADLEQQAPPRDHTHGTAQGHFMFILKTSNSLFQTAKLQSPTFSQTGPGCTMSFWFYNYGLSVGAAELQLHLENSRDTTALWRVLYNQGNQWSEATVQLGRLTQPFYLSLEKVSLAVYSGVSAVDDIHFENCALPPPVESCDEPDHFWCRQTKACIGRHQLCDLVDDCGDYTDETGCAPGLQCNFENGICNWEQSTKDDFNWTRYQGPTSTMNTGPMKDHTLGTAKGHYLYIETSGPQGFQDKAVLLSPILNATEAKVCTFRLYYHMFGKHIYRLAIYQRIWSNTKGQLLWQIFGDQGNRWIRKDLSITSRKPFQILIMASVGDGFTGDIAIDDLSFMDCTLYPDNLPMDIPSPPETSVPVTLPPNNCTDDQFVCRSNGHCVGNIQKCDFRYDCIDKSDESSCVLEVCTFEERKLCKWYQPIPANSLHDSNTFRWGLGNGISIHHGEENHRPSVDHTKNTTDGWYLYADSSNGKFGDLADIVTPVISLMGPRCTLVFWTYMNGATVGSLQVLIKMGNTISKVWAQSGQQGPQWKKAEVFLGIHSHVEIVFRAKRGVSYIGDVAVDDVSFQNCSPLLSTNRKCTTDEFMCANKHCIEKDKLCDFVNDCADNSDETTFICGTSSGRCDFEFDLCTWEQDQDEDIDWNLKASNIPATSTEPAVDHTLGNSSGHYIILKSFFPQQPVKTGRISSPVISKRSKDCKIIFNYHMYGSGIAALLLLQVTVTNHTRVLLNLTKEQGNFWQRKELSLSSDEDFRVKFEGRVGEGIRGNIALDDIVLTKSCLPSHHSTREEPAFPLPTGFCPRGYEECQNGRCYSPEQRCNFVDDCGDNSDENECGGSCTFEKGWCGWKNSLAENSDWVLGIGSYKSQRPPKDHTLGNEHGHFMYLEATPVGLHGDKAHFKSATWQESSAACTMSFWYFISAKATGSIQILIKTDKGLWEVWQQSKPDPGNHWRRATILLGKLRNFEVIFQGIRTRDLGGGAAIDDIEFNNCTTVGETTDICSEETDFLCQDKKCIASHLVCDYKPDCSDTSDEAHCGYYTSTAGSCNFETTSGDWTVECGLTQDPEDDLDWSIGSIIPTEGLSRDSDHTPGSGRHFLYVNTSLAEEGSTARIITSHFFPASLGICTVRFWFYMVDPHIVGILKVYLIEKSGLNILMWSMMRNKNTGWTYAHVPLSSNSPFKVAFEADLGGKEDIFIALDDITFTPTCASGGPALPQPPLCEEGQFACIYALQCVSASEKCDGQEDCIDGSDEMNCSLGPSPQPCSDTEFQCFESQCIPSLLLCDGVADCQFNEDESSCVNQSCPSGALACNSSGLCIPAHQRCDGTAHCKDIQVDESSCSECPIHYCRNGGTCVIENIGPTCRCVQGWTGNRCHIRSNLSTEGSVHTQNYIWTLLGIGLGFLLTHIAVAILCSLGIRRRPMRKSEGVGNHSFINPVYRNCINQEKTQSSIYSFPNPFYGAASGSLETVSHHLKS
What is the function of this protein?
Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis.
What are the official names of this protein?
MAM and LDL-receptor class A domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
Protein: XYLE2_PSEPU
Sequence: MKKGVMRPGHVQLRVLNLEAALTHYRDLLGLIEMDRDEQGRVYLKAWSEVDKFSVVLREADQPGMDFMGFKVTDDACLTRLAGELLEFGCQVEEIPAGELKDCGRRVRFLAPSGHFFELYAEKEYTGKWGIEEVNPEAWPRDLKGMRAVRFDHCLMYGDELQATYELFTEVLGFYLAEQVIEDNGTRISQFLSLSTKAHDVAFIQHAEKGKFHHVSFFLETWEDVLRAADLISMTDTSIDIGPTRHGLTHGKTIYFFDPSGNRNEVFCGGDYNYPDHKPVTWTADQLGKAIFYHDRILNERFMTVLT
What are the official names of this protein?
Metapyrocatechase, MPC, CatO2ase, Catechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the extradiol ring-cleavage dioxygenase family.
Protein: PEPQ_XANC5
Sequence: MPQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKAWVPLTRVPNSWLVYTPGKRPTVIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPEQALALLPKHAERCAILGEPQSTLGAYVPNNPQPVLDYLEYQRAFKTPYELALLRIAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRSFLIDAGASAYGYASDITRTYAADPGSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIEAHLALMGILKEFGVLTVSPEAALATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERPAGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAASVNWQRVEAFKPYGGIRIEDEVVCTDGSAENLTRPVFASA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: WDFY1_BOVIN
Sequence: MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVTAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFSSWASCLQYDFDTQYAFVGDYSGQITLLKLEQSTCSVITTLKGHEGSIACLWWDPIQRLLFSGASDNSVIMWDIGGRKGRTLLLQGHHDRVQALCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDVARGLMVTCGTDRVVKIWDMTPVVGCSLATGFSPH
What is the function of this protein?
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1.  Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.
What are the official names of this protein?
WD repeat and FYVE domain-containing protein 1, WD40- and FYVE domain-containing protein 1.
What are the subcellular locations of this protein?
Early endosome.
Protein: NSE1_DANRE
Sequence: MSRQMGDGHRLFLQNMMTNGIVSAAQAGMLHKKCCELHGGQEKIDDFINVVNTHLQPLFMHIRKGMSEEDGQEHFVLMDLIVESDSGSASSTAILNSADKLISKKLKKKEAELVLNKFVQDKWLKEQDGEYTLSVRCIVEMEPYMRTIYQDMIKVCYVCHNIALQCQVCENPSCEIKVHLPCVARYFRARSDPHCPACNDFWPHEIPEMQAAQSQSSQNLPSSSKENTAPTQTRRSRRV
What is the function of this protein?
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate.  Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex.  Involved in maintenance of genome integrity, DNA damage response and DNA repair.
What are the official names of this protein?
Non-structural maintenance of chromosomes element 1 homolog, Non-SMC element 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSE1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: PANX1_HUMAN
Sequence: MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
What is the function of this protein?
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116).  May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669).  Plays a critical role in oogenesis (PubMed:30918116).
What are the official names of this protein?
Pannexin-1.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SPEB_SALG2
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHHRFPWSFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLSAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPHHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDILAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: ESPG1_MYCSE
Sequence: MTAPFTAETGDAHIDDVVGVEVTIDGMLVIADKLGLTDFPPSMGIRLNIPQPDLRKVVWEQVERDLSAQGVLDVYGNPHPEVAAMVDTLARADRTLECRWWRRDAGGKMIRFVVCRKGGRHVVAARDNDLLVLQRVAPQIGLAGMVMTVLGEGSPANVEPLTGVADRLAQCRTAEELTGYGIPPTSARAYASIISEPDGWVEIVANERHPGGTTSQVDVAAGVLDAKQGRIVSIPRRVNGELYGSFLSGTKDNLERALEGLVEFLPSKTWFDKTDADNAYQH
What is the function of this protein?
Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (By similarity).  Specific chaperone for cognate PE/PPE proteins, plays an important role in preventing aggregation of PE/PPE dimers (By similarity).  Also plays a role in DNA conjugation, in at least recipient strain (PubMed:18554329).
What are the official names of this protein?
ESX-1 secretion-associated protein EspG1.
What is the protein family that this protein belongs to?
Belongs to the EspG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRG3_ARATH
Sequence: MSTIMQKIKEIEDEMAKTQKNKATSHHLGLLKAKLAKLRRDLLAPPTKGGGGGAGEGFDVTKSGDSRVGLVGFPSVGKSTLLNKLTGTFSEVASYEFTTLTCIPGVITYRGAKIQLLDLPGIIEGAKDGKGRGRQVISTARTCNCILIVLDAIKPITHKRLIEKELEGFGIRLNKEPPNLTFRKKDKGGINLTSTVAVTHLDLDTVKAICGEYRMHNADITLRYDATADDLIDVIEGSRIYMPCIYAVNKIDSITLEELEILDKLPHYCPVSAHLEWNLDGLLDKIWEYLDLTRIYTKPKAMNPDYDDPVILSSKKRTVEDFCIRIHKDMLKQFKYALVWGSSAKHKPQRVGKEHELEDEDVVQIVKKI
What is the function of this protein?
Binds GDP and GTP, and has low GTPase activity in vitro.
What are the official names of this protein?
Developmentally-regulated G-protein 3, AtDRG3, Developmentally-regulated G-protein 1, AtDRG1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Protein: QUEF_BURL3
Sequence: MNPEHSPLGKATVYAAQYDASLLFPIPRAGAREQLGITSALPFFGTDIWNAYELSWLNARGKPQIAVATFYVPAESPNIVESKSFKLYLGSFAQTTFDSIDAVRDTLKRDVSAACGATVSVQLVSPHDFGKLEMEELDGLSLDRLDLDTDVYEPDPSLLKAAEDEAPVEETLVSDLLRSNCPVTGQPDWGSVQIHYVGPQIDHAGLLRYIISFRNHTGFHEQCVERIFLDILHACKPVKLAVYARYTRRGGLDINPFRTNYNQPMPDNARNARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM2_ALOSE
Sequence: MVRYHVRSPSERPHREYRQLVNGQEQGRHGQEEQGMSAEGVEGYGRTHQGCYGYRRRLCSRRRLYRVHRRQRRSCRRRCCRYRRRNRRGCRTRRRTCRRH
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-2, Sperm histone P2, Sperm protamine P2.
What is the protein family that this protein belongs to?
Belongs to the protamine P2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HFQ_HAEIN
Sequence: MAKGQSLQDPYLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARSVSHHNNNHHTAPTEAVENVETQAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: CTAA_NITEC
Sequence: MQTNSSNSVPSAISDKYTQNHMPIAIWLLICCALVFAMIVVGGVTRLTGSGLSIVEWKPIVGTIPPIGQEDWEVLLEKYRQIPQYEQVNKGMTLDEFKGIFWWEYFHRLLGRLIGLVYFIPFVYFMVRKRIDRLLGLKLLGIFALGALQGLMGWYMVMSGLADNVYVSQYRLTAHLGLAFVIYAAMFWVATGLISPLNTHLSDPVSVHKLKKFAWMLTGLIFVMVLSGGLVAGIHAGRAYNTFPLMDGFLIPPAMFVLEPWYRNFFDNITTVQFDHRLIAWLLIFSIPWFWFKAKQLSLSYSGRLACHLLLLMLLIQAGLGITTLLLSVPLTFATAHQAGAVLLFTAALWVCRKLS
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SODC_RABIT
Sequence: MATKAVCVLKGDGPVEATIHFEQKGTGPVVVKGRITGLTEGLHEFHVHQFGDNRQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTAGSNGVADVLIEDSVISLSGDMSVIGRTLVVHEKEDDLGKGGNDESTKTGNAGSRLACGVIGISP
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: N4BP1_XENTR
Sequence: MASGSVQSSSGNGRRQAAVVDEFTVPGDKRSLLEKSRPRIQALFPVLFTVLGSLETFQQSEVKEDEEKPGRIWLQLKGEKQAVRRAKEYVKGICEPELEEKQSYPKEMHCIFAGAQSSFLNHLIQDTCADVALSDIGVLGIKGATEPVVMAQSRVQQFIALFKDNLSLPSHKEPAVKKKFKLYVEKHVDKYTVDLLLLPSALKSELLSLACDNQLSCEDLSRQSSDDKAECKVNQKDEVSRKGAGTPVTELTSQLDSVFSSAAEDSPCLIECPYSEQDRLSVKRRSSEAEERFSKKPFSLEAVQVDGPVNRNADKNNVPIIDLISEPSDFEDSVIVVEADDCVSSETEYKILVNFFKTMGYSQIVVEKVIDDLGQSEEPLKLLEEIEKQSKKELSVPFSQSSSYSTDLLKARGTSSLPKCKIAIAETVQSAAPSKVQPKALLATDKAGPSNPFCYKSQTKATVVNPIPTDQTTIVAPAERAFNNHFDPPLTGVQIFQNSLKVQYRLELKNEPGRWDLKHIIIDGSNVAMSHGLQRFFSCRGIALAVEYFWKKGHRNITVFVPQWRTKRDPFITEQHFLQQLQELGILSFTPSRTVLGARIASHDDRFLLHLAERTGGIIITNDNFREFVVESPSWREIIKERLLQYTFAGDIFMLPDDPLGRYGPKLDDFLSKQPNNRTVHSSFPSSNERFVPRDQFAPPRNMAPKTGLNQPMAPRAGHNQPMAPRAGHNQPMAPRTGLSQHRFLQLIKPQEPFTPALHNIARPCPIMPPERSPSETMQLKEALLKIFPEADQRHKINEILTAHPFMRDLNALSAMVLD
What is the function of this protein?
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation.  Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity).  Has ribonuclease activity (By similarity).
What are the official names of this protein?
NEDD4-binding protein 1, N4BP1.
What is the protein family that this protein belongs to?
Belongs to the N4BP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated.
Protein: CRTD_CERS4
Sequence: MRQIVPKVVVVGAGMGGLASAIRLARAGCEVTLLEAREAPGGRMRTLPSVAGPVDAGPTVLTLREVFDDIFEVCGQKLDHHLTLLPQPLLARHWWLDGSTLDLTTDLEANVEAVAAFAGAREARAFRRFHDLSARLYDAFDRPMMRAARPDLRAIATGALKAPRTWPALLPGMTLDRLLRLFFRDRRLRQLFGRYATYVGGTPYGAPGVLALIWAAEARGVWAIEGGMHRLALALARLADDQGVRLRYGAPVARILRQGGRATGVQLADGRTLPADHIVFNGDPAALLAGCLGDGPQDAVPEDRIHPRSLSAWVWSYAARASGPPLVHHNVFFADDPRREFGPIAAGQMPEDATLYICAEDRSGGQLPDGPERFEIIMNGPPGRPAKPEDFAQCRSRTFDRLRQFGLTFDPVPGETSLTAPSGFASLFPASQGSIYGLSPHGALASLKRPLARTALPGLWLAGGGAHPGAGVPMAALSGRHAAEAILADLASRSR
What is the function of this protein?
Catalyzes the introduction of C-3,4 double bonds into 1-hydroxyneurosporene (1-HO-Neu) to yield demethylspheroidene (DMS).  It prefer the acyclic carotenoids such as 1-hydroxylycopene, and 1-hydroxy-gamma-carotene, whereas 1-hydroxy-3,4-didehydrolycopene and 1,1-dihydroxylycopene are much less effective.
What are the official names of this protein?
Hydroxyneurosporene desaturase, HND, 1-hydroxycarotenoid 3,4-dehydrogenase, 1-hydroxycarotenoid 3,4-desaturase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family.
Protein: CASP6_HUMAN
Sequence: MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
What is the function of this protein?
(Microbial infection) Proteolytically cleaves the N protein of coronoviruses such as MERS-CoV and SARS-CoV (PubMed:35922005, PubMed:18155731).  The cleavage of MERS-CoV N-protein leads to two fragments and modulates coronavirus replication by regulating IFN signaling.  The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes (PubMed:35922005).  The same mechanism seems to be used by other coronaviruses such as SARS-CoV and SARS-CoV-2 to enhance their replication (PubMed:35922005).
What are the official names of this protein?
Caspase-6, CASP-6, CSP-6, Apoptotic protease Mch-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: C2C2L_HUMAN
Sequence: MDPGWGQRDVGWAALLILFAASLLTVFAWLLQYARGLWLARARGDRGPGPALAGEPAGSLRELGVWRSLLRLRATRAGAAEEPGVRGLLASLFAFKSFRENWQRAWVRALNEQACRNGSSIQIAFEEVPQLPPRASISHVTCVDQSEHTMVLRCQLSAEEVRFPVSVTQQSPAAVSMETYHVTLTLPPTQLEVNLEEIPGEGLLISWAFTDRPDLSLTVLPKLQARERGEEQVELSTIEELIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPMMPQAQPAIPRPNRLFLRQLRASHLGNELEGTEELCCVAELDNPMQQKWTKPARAGSEVEWTEDLALDLGPQSRELTLKVLRSSSCGDTELLGQATLPVGSPSRPLSRRQLCPLTPGPGKALGPAATMAVELHYEEGSPRNLGTPTSSTPRPSITPTKKIELDRTIMPDGTIVTTVTTVQSRPRIDGKLDSPSRSPSKVEVTEKTTTVLSESSGPSNTSHSSSRDSHLSNGLDPVAETAIRQLTEPSGRVAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASVQDDAGTSGGPSSPPSDPPAMSPGPLDALSSPTSVQEADETTRSDISERPSVDDIESETGSTGALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLSNATATPSVRKKAGSFSRRLIKRFSFKSKPKANGNPSPQL
What is the function of this protein?
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843).  It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843).  Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843).  In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843).  Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843).
What are the official names of this protein?
Phospholipid transfer protein C2CD2L, C2 domain-containing protein 2-like, C2CD2-like, Transmembrane protein 24.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes to sites of contact between the endoplasmic reticulum and the cell membrane (PubMed:28209843). Embedded into the endoplasmic reticulum membrane via its N-terminal transmembrane domain and associates with cell membrane via its C-terminus (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane and localizes to the reticular endoplasmic reticulum (PubMed:28209843). Reassociates with cell membrane upon dephosphorylation (PubMed:28209843).
Protein: RS3A_METS3
Sequence: MAKAKARRRVRDTWKEKSWYTIKTPVNFEDKEIGETPARDPDYLIGRGVEVTMRELSGDFSKQYIKLRFEIDNVAGDVANTKFTGHKTTTDYVRSMIRRGTSRIDASSVVKTKDDRKVKLHVLAVTTRRAKSSQQKYMRQVINDLLAETAAEKSFDELIKLVVNGKLASEVYHNAKKIYPLKRVEIIKSKVLN
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.