PharMolix/UniProtQA huggingface dataset:
Protein: ALG3_DEBHA
Sequence: MTEQSIKDGQRPELPPFTLRNVLNDIYNGILALFTDPFCTRIICPVVIVLTSLLSKAIIYKVPYTEIDFRTYIQQIQIINDGELDYSLVQGDTGQIVYPAGFVQIYQVLNWLTDEGTDIHAGQTAFGYLLALTNFLVIIAYTMTPDFQPWPVYCLLLSKRLFSIYVLRLFNDCFTTVCMVSVTILLQQAAYWYKKGGSSISFLLTMVAADLYSIAISIKMNALLYFPGFIIVAYFLCGENLLKFGTVLLVIPIVQVLMGWKFLLPFFNDEEASYIRWNYINQAFNFNRKFLYKWTVNWRFVSEEFFLSDVFSNGLLIANASVLIFFIFTRYISPRITCKPVSRLIKDAMVGPFSSTINKNNLLIDPKCGPKLVMLILGSTNIIGILFARSLHYQFLSWYCWQLPFMLYMTGWSLLVCIPLWVVHEWCWNVFPSTPMSSGLLVSILAIVLFGVWYNTNEWFPKLADNEAATIDESGESKKDK
What is the function of this protein?
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, Asparagine-linked glycosylation protein 6, Dol-P-Man-dependent alpha(1-3)-mannosyltransferase, Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HLYB_VIBCH
Sequence: MIINKFSLKWMLAIAVAIPAIALLFVAFTSLNTMSVMQAQSNSLYANTAAPMRAMAEATSRIPRMRVGIDMMLLQETALKDAKGVLKRVEEARTEDIPEMRQAMQVAVDSQVNPELKEQARKLQARFEQMVREELEPMLQAFANNDMTTAQNIYRDKYAPTYGEMRKQANQILDTLLQQAEQQNHASVESFEAGRTKQMVIIAAGLIISFITSLVIITNLRSRVAYLKDRMSSAAANLSLRTRLELDGNDELCDIGKSFNAFIDKVHHSIEEVAENSKELATMASSVSQRAHMTQSNCASQRDRTVQVATAIHELGATVSEIASNAAMAADVAKQATLHSGEGKKVVGEVQNRIQTLVNELDNATQVVSSLATQINGISSTLDTIRSISEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLASRSAASTEEIQQVINRLQTESTRAVEAMEKGRSQSDVVVEFSAKANQSLTEINSQIDQINDQNIQVATATEEQSTVVEDINRNVEDINQLTTETSHVADELSRASASLQRLSSQLDKLVGSFEL
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
What are the official names of this protein?
Methyl-accepting chemotaxis protein HlyB.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATFB_ASPFN
Sequence: MSVDQTLYSRTPAAMADPTCAGPAAFTAAGAFSQPDLMAFSLREEEPIWGFDTIAPSMASWQGKMEQQTFCNPNMERGLKNTHVRNGQPTPPPFDDKKLQTPMGEMYPVAQYAFNSSPPEYAPPKHRSSLSEQSQTDGYGVSTRRRKASAIDQCEQQQEREKREKFLERNRLAASKCRQKKKEHTKLLETRFREVSNKKGELESEIEHLRSEVLNLKNEMLRHAQCGDEAIKIHLAQMVRLITSKDTPNRDLVSPMRSPEQMAASTPHGLSFGFDGPMQLPSEMGSPLDQRRDSEQSIMTESSYTFSTDDSFEELINV
What is the function of this protein?
Transcription factor that acts as a key player in the regulatory circuit that integrates secondary metabolism and cellular response to oxidative stress (By similarity).  Regulates the genes involved in development and stress response through direct binding to their promoters (PubMed:24951443, PubMed:28830793).
What are the official names of this protein?
Basic leucine zipper (bZIP) transcription factor atfB.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CXCR4_MACMU
Sequence: MEGISIYTSDNYTEEMGSGDYDSIKEPCFREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQKPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIDILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.  Involved in the AKT signaling cascade (By similarity).  Plays a role in regulation of cell migration, e. g.  during wound healing.  Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.  Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).  Involved in hematopoiesis and in cardiac ventricular septum formation.  Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells.  Involved in cerebellar development.  In the CNS, could mediate hippocampal-neuron survival (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, Stromal cell-derived factor 1 receptor, SDF-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).
Protein: HIP2_ECTSH
Sequence: MERLSEDDPAAQALEYRHDASSVQHPAYEEGQTCLNCLLYTDASAQDWGPCSVFPGKLVSANGWCTAWVAR
What is the function of this protein?
Specific class of high-redox-potential 4Fe-4S ferredoxins.  Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.
What are the official names of this protein?
High-potential iron-sulfur protein isozyme 2, HiPIP 2.
What is the protein family that this protein belongs to?
Belongs to the high-potential iron-sulfur protein (HiPIP) family.
Protein: TVA41_HUMAN
Sequence: MVKIRQFLLAILWLQLSCVSAAKNEVEQSPQNLTAQEGEFITINCSYSVGISALHWLQQHPGGGIVSLFMLSSGKKKHGRLIATINIQEKHSSLHITASHPRDSAVYICAVR
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 41.
What are the subcellular locations of this protein?
Cell membrane.
Protein: DBP10_CRYNB
Sequence: MAAITPSWALETTADGEVKEKTSGPGGQWRALNVGPDLIRSLLIRKFKTPTPIQRAAIPPALSTPPRDILGMARTGSGKTLAYLIPLLQRTGSTHHGQGPRALILCPSRELAVQIYTVGKDLARGMNKGKGKGKNKNEDEEDEEGKGKEGLRWALIIGGEGMDAQFEKMSSNPDIVIATPGRFLHLIVEMHMDLRHLQTVIYDEADRLFEMGFDVQLQEILHRLPSTRQNLLFSATLPSSVAEFAKAGLVNPLLVRLDAEQKISPDLALKFFSVKPGEKEASLLVLLREVIGKPNQPEPADPSSAPQAIVFVATKHHVDYVAELLRTTGYRTSLIYSSLDQVARQQQLAGFRSHQSDVLVVTDVAARGLDIPIMDHVINYDFPAGPRIFVHRVGRTARAGRKGTAYSLIVKEDFPYLCDLHTFLGTERMGEPADVLRSLPIEQLSENVEYVFHNLDETAPHITALRNVMRKGQGMFERSRTKANPTSYRQAKSLASALSNNPPRIDDMFEDAMEVEVNEEKARLLAKVAAFTPSETVFEVGKRESESAIIMKKRRKTVDERQKRVSKAEAEKSTASGMEKAPVKELPAPQLPSKNFKDPSFYLDHTQRGAEAEKGYSLKSGVESLSGAITDMTADEGTGPKAQKASQLSWDRKKHKFIKKNGSADGEKMIKSESGALLPASYSSGKYQEWKSKRRHMPDGPVEALALGGGRRGRHGPPGQKRKAEDGDGGEDAGGKGRKDQGKSKGTGKGKDDFKQKSPGKPGKKGIKQSSGLKSAMDIRKQREIAQKRKEKNARKPQKFRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL5_STAAC
Sequence: MNRLKEKFNTEVTENLMKKFNYSSVMEVPKIDKIVVNMGVGDAVQNSKVLDNAVEELELITGQKPLVTKAKKSIATFRLREGMPIGAKVTLRGERMYEFLDKLISVSLPRVRDFQGVSKKAFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTANTDEEARELLANFGMPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: DCDB_METS3
Sequence: MAILSDKTIKEYLEEGKIVIDPLKDEQQIQPSSVDMRLGDEFKVFKVIRKPYIDPKDEEDIAEYMESSTVPEGEAFIIHPNEFALATTQEYVKVPDDLVARVEGRSSMGRLGVTMHVTAGYVDPGFEGRITLEISNIGAMPVALYPGQRVCQLVFETMTTPAELPYGHPKRNSKYMKQLKPESSRVKLDYELKK
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: PUR7_LEPIN
Sequence: MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENRIGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILRNYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: IHFA_SINFN
Sequence: MSGKTVTRADLAESVFRKVGLSRTESAELVETVIDEICNAIVRGESVKLSSFATFQVRDKNERIGRNPKTGEEVPISPRRVMTFKASNVLKQRVLKAHLSRRAKQKQTGTAS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RG190_DROME
Sequence: MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGDVRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEKEYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYELYVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELLDTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNKKLHQYLDKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNLELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDFIDHTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANEHSIIVDVFIGDAKRRVEFILSSYHGTSQYRDELIHGYIYFYSTKRRSSLANLSILAAQNANIPLQIIAVTESGGVNAFFNSDICQFLITEGNAVADRFKGSFMTFSADQYVKFAFYNPFLKTAWDNKYEVENLHVEESITLDSGEGTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDISLDEIYDDNEKPKHLHQKWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGSGPEKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLFCGKDAFVMV
What is the function of this protein?
GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons.  The MB neurons are the center for olfactory learning and memory.  Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.
What are the official names of this protein?
Rho GTPase-activating protein 190, Rho GTPase-activating protein of 190 kDa.
Protein: RL2_SYNP6
Sequence: MGIRAFRPYTPGTRERVVSDYAEITRNEPEKSLLVSKHRRKGRNNRGVITCRHRGGGHKRLYRIIDFKRDKRNVPGKIVSIEYDPNRNARISLVYYEDGEKRYILTPAGVHVGTPIIAGDETPIEVGNAMPLQNIPLGTTVHNVELVAGKGGQIVRAAGASAQVVAKEGNYVALKLPSTEVRLVRKECYATIGAVGNAEVRNTSLGKAGRKRWLGRRPEVRGSVMNPVDHPHGGGEGRAPIGRSGPVTPWGKPALGRKTRKKNKQSDCLIQRRRRKSSKRGRGGRDA
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CITG_VIBCH
Sequence: MTIPAALDLLLELPSQASSSSGSRTFSLPRLVGHLAYHAMMLEVHLTPKPGLVDTANNGAHRDMDLNTFIASAEAIAPYLHSFVSAGWESAGNPAAQLLSALRPIGIEAEQAMFAATQGVNTHKGMIFILGLICGSVGWLKANQLKIDAQHIGETIRQACQFLVIDELKAKRDCEPETAGERIYRQYGLTGARGEAASGLAMVMQHALPAYQACLTKGASTEQALWHTLLVLMANNNDSNLVSRGGLAGLHFVQEQAQQLLAKGGFLYQEIEQALTALDSVLIEKHLSPGGSADLLAATWLIYELVQLFKVRH
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: VP2_LORDV
Sequence: MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQASFQFSSTLQQASFQHDKEMLQAQIEATQKLQQDLMKVKQAVLLEGGFSTADAARGAINAPMTKALDWSGTRYWAPDARVTTYNAGHFSTPQSLGALTGRTNSRVSAPARSSPSALSNAPTATSLHSNQTVSTRLGSSAGSGTGVSSLSSAARTRSWVEDQNRNLSPFMRGALNTSFVTPPSSRSSSQSTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV
What is the function of this protein?
Minor structural protein present in one or two copies per virion.  Stabilizes capsid protein VP1 by protecting it from disassembly and degradation.  May play a role in RNA genome packaging (By similarity).
What are the official names of this protein?
Protein VP2, Minor capsid protein.
What is the protein family that this protein belongs to?
Belongs to the norovirus VP2 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TIG_CAMFF
Sequence: MEVKAKLLNTANAAAQTEVKASELNAKVENLAKKAAKNIKIDGFRKGKVPVAQVLKRYGKDLENDAKSEIFRDIVNESLKLIAKKSSDIIGEPMILKFDEKDGNIDIELEISFKPEVKVDGYEEIIPEYTTPKVTKKEIEEKINEFLKMIAPLEKVEKESLEKGDFAKFDFEGFVDGEAFEGGKAEGYLLEIGSGQFIPGFEDGMLGLKVGEQKDVNVTFPAEYGAAHLAGKSAVFKVKLHEIQGKKAGKLDEETLKKLMPNEENPTAEQLEDRIKEQIRADKFQKLLNEDLKPKFADKAVEKFKFDLPNNIVEQEIDMQFRSAWGNFSEDEMKKFREDKEALKKQRETYKNEAIKSVQLTFIIDELAKQKGITVSDNELLQAVYFEAYRYGIDPKEHLESYKKQGMLPAVKMAMIEEKLFNNLFKSGNREDKGE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PCNA2_DAUCA
Sequence: MLELRLVQGGLLKKVLESIKDLVNDANFDCSASGFSLQAMDSSHVALVAVLLRSEGFEHYRCDRNISMGMNLGNMAKMLRCAGNDDIVTMKADDDGDVITFMFESPTQDKISDFEMKLMDIDSEHLGIPESEYEAIVRMPSAEFARICKDLSTIGDTVVISVTKEGVKFSTRGDIGTANIVCRQNTSVDKPEDATIIEMQETVSLTFALRYMNSFTKATPLANQVTISLSSELPVVVEYKIAEMGYIRYYLAPKIEEEDEAANYAQPAQNSAAAATSNNGTKKNEGNNKVDSKKRAIKSEFVDDSEAATDAQPQAKAKTKTEAGEDDDVEVMDTKPKNEPDDGDEVMETKPKTESNGEVEVMDIE
What is the function of this protein?
This protein is an auxiliary protein of DNA polymerase delta and may be involved in DNA replication as its carrot homolog, typical PCNA.  The larger PCNA is perhaps processed thus bestowing on it exactly the same function as its homolog.
What are the official names of this protein?
Proliferating cell nuclear antigen large form, PCNA, Cyclin.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PG029_VARV
Sequence: MNVYNKADSFSLESDSIKDVIHDYICWLSMTDEMRPSIGNVFKAMETFKIDAVRYYDGNIYDLAKDINAMSFDSFIRSLQNISSKKDKLTVYGTMGLLSIVVDINKGCDISNIKFAAGIIILMEYIFDNTDMSHLKVALYRRIQRRYPIDDDEEDR
What is the function of this protein?
Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factors 3/IRF3 and 7/IRF7, transcription factors critical for the induction of interferons alpha and beta.  This blockage is produced through the inhibition of host TBK1, by binding host TBK1 adapter proteins TBKBP1 and AZI2, thereby producing a strong inhibition of the phosphorylation and activation of IRF3 and IRF7.  Acts also as an inhibitor of the cellular response to type I IFN by interacting with host STAT2.  Mechanistically, exerts its inhibitory effect after host ISGF3 complex (composed of STAT1, STAT2 and IRF9) binding to the interferon stimulated response element (ISRE).
What are the official names of this protein?
IFN signaling evasion protein OPG029.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG029 family.
Protein: RS5_VIBPR
Sequence: MAKEQQVQANDLQEKLIAVNRVAK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS8_CHLFF
Sequence: MGMTSDTIADLLTRIRNALKAEHLYVDLEHSKMRESIVKILKHHGFLARYLVKEENRKRTMRIFLQYSDDRRPVIRQLKRVSKPSRRVYVPAAKIPYVFGNMGISVLSTSQGVLDGSTARAKNIGGELLCLVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TAA8C_RAT
Sequence: MTSNFSQATLQLCYENVNASCIKTPYSPGLRVLLYMVFGFGAVLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESCWYFGDTFCSLHSCCDVAFCYSSALHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISISWILPLVYSSAVFYTGISAMGIENLVSALNCVGGCQVVVNQDWVLISFLLFFIPTLVMIILYSKIFLVAKQQAVKIETSVSGSKGESSLESHKARVAKRERKAAKTLGVTVLAFIVSWLPYTIDTLIDAFMGFITPAYVYEFCCWSAYYNSAMNPLIYAFFYPWFRKAMKLILSGKILKGHSSTTSLFSE
What is the function of this protein?
Orphan receptor.  Could be a receptor for trace amines.  Trace amines are biogenic amines present in very low levels in mammalian tissues.  Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.  Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
What are the official names of this protein?
Trace amine-associated receptor 8c, TaR-8c, Trace amine receptor 8c, Trace amine receptor 10, TaR-10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLND_YERPG
Sequence: MSDNHTEHSLSLTLTPTISEQPALPSTYLDSDIHCPILKQRLDAFQRWQAEAFNSGTSAEVLIAARSDYIDHLLQRLWTFYGFDKVPETALVAVGGYGRGELHPLSDIDVLVLSKQRLNDEQAQRVGQLITLLWDLKLEVGHSVRTLEECLLEGLADLTIATNMIESRLICGDVALFLQMQKHIFSDSFWPSPQFFHAKVVEQQERHKRYHGTSYNLEPDIKSSPGGLRDIHTLLWVARRHFGATSLSEMVDFGFLTNAERNELNESQSFLWRIRFALHLVLTRYDNRLLFDRQLSVAQLLRYEGEGNEPVEHMMKDFYRMTRRVSELNNMLLQLFDEAILALDANEKPRPLDEEFQLRGDLIDLRDENLFVRQPEAIMRMFYLMVRNQDIKGIYSTTVRRLRHARRHLKAPLCHIPEARKLFMAILRHPGAVSRALLPMHRHSVLWAYMPQWGSIVGQMQFDLFHAYTVDEHTIRVLLKIESFADEDTRPRHPLCVELYPRLPQPELLLLAALFHDIAKGRGGDHSILGAHDAVEFAEQHGLNSRESQLVAWLVRCHLLMSVTAQRRDIQDPAVIQQFSAEVQSETRLRYLVSLTVADICATNENLWNSWKQSLLRELYFATEKQLRRGMQNSPDLRERVRHHRLQALALLRMDNIDEEALHRIWSRCRADYFLRHSPNQLAWHARHLLEHDSTKPLVLVSRQATRGGTEIFIWSPDRPSLFAAVVGELDRRNLSVHDAQIFTNRDGMAMDTFIVLEPDGSPLAQDRHPIISHALQQAINRSDYQHPPRVRRLSPKLRHFSVPTEANFLPTHNERRTYLELIALDQPGLLARVGKIFADLGLSLHSARITTIGERVEDLFVLADKDRRALSLETRRELAQRLADTLNPNDKL
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: PGPIL_MOUSE
Sequence: MDSSAKAIFLEQCGKNRGYRDSDVRGFQPEDGVCLPGGPEVRLSVVNMKEVCRRVAVENVEVAFSRDAGRYICDYTYYLSLPLGTGHAALIHVPPLSHWLSASLLGKALRVIIQEMLEEIGKVQTQSTAA
What are the official names of this protein?
Pyroglutamyl-peptidase 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.