Protein: SMG1_DANRE
Sequence: MSRKALGSRLSSAHKLQRNWNDWQPRSDSLSASQDGVKCSVSRDRGSEVLFEILPSDRPGTPPLHNDAFTATDALEEGGGYDADGGLSENAYGWKSLGQELRINDVTTDITTFQHGNRALATKDMRKSQDRPLAHSEESRLANLLRRASREDDRERRLATMKQMKEFIVHSENKVVLVKQLDSILSTLNDILNESSKLLQELRQEAAWCLGLLCAALSYEAERIFKWMFLKFSVSTKDEVKLLYLVAVHKALETAGEKKAFSAVMQLVMSNLQSILENLDTPELLCQSVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKHSLTQQVSGWLQSLEQFWVADLAFSTTLLGQFLEDMEAYAEDLSHVVSGESGDEDIPPPTVSLPKLAALLRVFSTVVHSIGERFNPIRGPPITEAYVTDVLNRVLACVTTAKQVFFSEAVLTAGNECVCVLLVSIDLGGQLIDAVISYGLDQLNCCQNCGPEYSLSVLTLLTLVVDQINTKLPASFVEKLLAPKSHLLELRFHREREVMAAAHGVYHAVLSLKNIPILEAAYKLVLGEMGCALNSLLSPLGLPDACPHIQHPAFSQLNFSPERAEFVLIFNLSALTTIGNTKNSLIGMWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKRHFSTLLNLLGMLLSKDHLNPEARRLLLTWSLEVALMMKKSETYAPLFSLPSFLKFCKGLLANSLNEDTTICLQACNSLQVLSSSLTMELLQRCVDVCRVQLVHSAVRVRQAFGKLLRSVPMHVALSAHSHSEIKEISLAIRRHMSKVPSNTFHPQDFSDLIGFILYGTVHRGGKEPWLERLYHSCQRLEKKDSAMVPRALLKTEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSGGESDEGHHTNQLRLALLLQFLENLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTEIKNSSTQGPEMEVPVTMLVEALCELRCPEAIQGLAAWSLANTGKSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMDCSIKVFDRSLLKLTGTNTSSPKHTSSGEGRKTVLLKSSECSPEVLNFLANKACECYVALSDWESVQEWQASMMNLKKNSSSSSVNLKTDFNYIRSMSRFEEGDFTECRAQLELLPGDDYGLLNSTTKDKIDLKRLLPAVLSPDPSELQKAIEVQLLRSAVGAISATNHEQDQKVASSDTLVKYLKQTGRICLGPLRLSTLTLSDSLPTLSTLQLHCANSLENSLCNQHPEDCLIPLFSEALTTCKQQDVQPWLHALRYTTFQREFFQKLKGSSSPVDSHLMELCLTAVKFARKQGNIALATRLLSLCSKPAMSDTEGQDLVQSFRQLSLEGTVGEKWGPELEIEKAKVLFAAGQSVSAMEMLSSCALSYCHSGKCELAACRSVLTLCKWLLADWKDLTPQLKMVVKKNSGSTSLSTLSKNISGLLELPLEDQGMPHITTETTVSVGVGEPDFVLGQLYQLSTTQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVPLLLGEKKEIEELLPAGTSDEDKETIFGILGQAMCRPAGIQDEDMALQNEEDDEDDMVDVIGRQLLGACPWLSDVEDTVTDGLIGVWRRVVDRIFSLYRVSCRAYFTFLKLNAGQVPIDEDDPKLLLNNQNSKQSSDDVIVMATLRLLRLLVKHAGELREGLEHGLASTPTAPWRGIIPQLFSRLNHPEAYIRQSICSLLCRVAQDSPHLILYPAIVGSISLGGEAQTAGNKLPSSLPTLLGNMQGEGLCGGESETGSGPTSQESSRGEEMVMYSSEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVGELRRVTLLWDELWLGVLQQQHMHVLRRIQQLEDEVKRVQNNNTLRKDEKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQETYGDAIHNALERLRSPLNPANPASSWVPFKQIMLSLQQRAQKRASYLLRLDEISPRLTAMANTEMALPGEVSATDAVTIQSVGNTITILPTKTKPKKLYFLGSDGRNYPYLFKGLEDLHLDERIMQFLSIVNTMFTKVNQQESPRFQARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAVVQAQKAQDSFQQPQNLPMVPRPSELYYSKISPALKAVGLSLDVSRRDWPLSVMRDVLRELMEATPPNLLAKELWCSCTTPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGVEGIFRLSCEQVVQIMRRGRETLLTLLEAFVYDPLVDWTAGGEVGFAGAVYGGGGQQAENKQSKREMERDITRSLFSSRVAEIKVNWFKNRDEMTGVLPQLEEAVDEYLNLQEQLTQVEKVQGKLLEELEFLEGADTRADHPIHSLEHRYSEHTQLQSRQRTVQDAIQGKLSDLDQWISQYQAAFASLEATQLASLLQEISSPIDLGPPSYVPATSFLQNAGQAHLISQCEALEAEVSALLQQRRSQLRGCLEHLHSYATVALLYPRAVLHRHRAHTWKQWMEELVCDMTVDHCQTIYHQYEMQFAPQPPPATCQFLSSIEMALQHHAAETNTRLLRQVERLKAEGASVPVCEEQLQEIERCIKVFLHEDAELGSFSLAGIIVSALCSLTRRNLVMEGAAASAGEQLVELTSRDGAWFLEELCSMSGNITCLVQLLQQCQLLSHDLDIPSPAETSQVVYLTNGVYTCLQELNTNFRQIIFPEALRCMLKGENTLETMLAELDALIDQCADGVSLQGLGEILMAHIRNASMGLEEDPDDHYLDVTRVLRAQYSELIQPRSMESSVQETPKMSAGQMLLVAFDGMFAQLETAFGLLIDKLNSMDVPAAWRKVDVIRESRATQAHFFDNVQTRQVLEEIFFLKRLQTIRDFFRLCGSFAQTLSGTCPTPTDDPPPSNGPVPIVKPLYRGSTVVSEDQMTRPIKAFTADFVRQMLMGLPTQALGLAICSSLSALGMDLIAQVEAKDFGAEGKVSLDDLCKKAVEQGVQAGRLSQLLLNRATVLASSYDTAWKKLDLVRRLEVSIEACKVSLQRNQLHIAMFQWQHEDILGARTQPMTVSPPPRSIILSNMKKKLYKLSQDDASIGSVQEKLASLEGSIEQRLKWAGGANPALAPVLQDFEATIAERRALVIKESQRANQVTFLCSTILNFEGLRTRTPEALNMDAALFELVKRCQATCSYAAQFNTSVSSLELQLLHRLSPAMDMSIGGPEWLVYAQNHLTQEMSSQRAMQEEREQQLESVTETLQLLVDSIKGTLSNHNRQLADVKHLLRAMAKDEENALAEGEEVTYDGSVRQFLSEYKAWQDNVQIVLFTVVQATGQPRSQEQIELLQEIPATLKELKVQSHSIYNGLVGFASPLVTERGSDCISPTSTVQTSFAAAVRCSGVKTQPDSMSQNARKALPRNFGTPADTPPSTLMINSKGLAPSPKRAVRDPKTGRAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVTEQVDYVIKEATNVDNLAQLYEGWTAWV
What is the function of this protein?
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways.  Recognizes the substrate consensus sequence [ST]-Q.  Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1.
What are the official names of this protein?
Serine/threonine-protein kinase SMG1, smg-1, Nonsense-mediated mRNA decay-associated PI3K-related kinase SMG1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.