Protein: GCYA_PLAF7
Sequence: MSDSKKHYNESNVRYKVKYSGKIFGNNMKKLNENNNHDFTTAEAAWMEKKKKLYKDTNNQPLWDFRKIQINPTETDELISFPSNKICSKNYGKYSFIFKGLYEQFLRLPNIWFLLISLLEFIPQYQNLSNYMYYSKHSSFFLLLFFICVSIIKNIYEDSRRSNIDYQINNRLCHMLDGPNSQLKAVRWMELSVGSIIRLIENEQVPADILLLSCNNSEGVVYIETSLLNGETNLNKKYCVNETRNETSIYAISNIRGRIVCEKPNSNMESFNGSLKLDAHPRATSLSINNVIFKGSHIKNTEYIFGVILYTGNDTKIMKNISNNKHKLGYVNKELNSYTIIGLIFTFICVFISVLFKWTEDDKFRNGSHFFLITVKDNICESIVKYTLLYSNIIPISILISVDLISILQSILIENDNHISTFENYETSEPSTIDDMDNELGDFKMDKSHTFFKKYTYFLNNRSKNFTNNRYSSTNTERASDFRKSFFGTFDKLKTIKRYFYSIKSKIKSISQSNTLYNKSSAGGSIIRSDKNKQTTFSKSFIDIFQRTNNNEHSQTLDNNNNNDNNNNNNICKEKYQNVNNSKNVYVSEDSSNNKYKQNDYLQKSQEQNEIHSINNNNYNNKNDNNLQTEFSNHNFRINAYKTNRTTKDDTYNNKHISLNSRSKSNQKGILINSNEINRKKKKNLLQKIFPFFKKKRTNISEDLSKYVFRRSKQLNINHNNSEKYNLNDYDEYGWGLCLNSNMHGDLGNVDFIFTDKTGTLTNNNMTFNMCSIAGKTYGSKCKNKKKIYNNPKSNNDNKLNSYDKNIFKNKFSSEASIKKISFVRDFSNNVSSKNDLTLDDPTELISDEGNNYLRDKYEHTSDKKNDTNKNRDGANNSNNNNNKDVSNNKNKNNNNYNYNSNNDYIKQNGECNIYNNQNNTNNTHNNNIYYDEYNNTNEGNMKNTNVNKDTNSKCNKKDFIINTSDIINNNNNNNNDQKTNNLKYKSSSSWNSKAKKSSYINLNSYNKYQSFQNSSMLSSSLSSTCSSETEDENGSQLMYYSSSNYDNLDINNDMDSTKTYSHYTEQNYYNSVKDDKDINSEHQRYQQKKTNKQTKNIQQNQCDQWEDNRYTQESIKNQYFFDRNYQTFLMKQNFPRPKSFRLNMNSSSVKGRCDFNDTKIYNDLNSQSWRGYYIDEFFKCMTLCHAVTPFIQFDYIRNKHLTYTNSRSSKGISNNMDRYNINPTTTTTNNNNNNNNINNINNINNNNNNNNNNNNNKQFSCDYMKNRNDIIFETSTDYYANQDNAKRKREKTLFDNVSHCGEIQEYRDNKKYRMKRSQTCSNNRKIFSNQRTLYDYRNMNNNLKNKNSYLRNKLKSKIFLDKSYRKRKKSSGTYKGSDICKGIEKKETRRWKRFLHMKGSNNRNIFSRIKDFKSNSIIYNNQDKTNDYKNGYSNNINNNNSNNYTNEKINRSFNKRHSAVSFKQMSKEKLIPINNVLSNRCDVESYPNEELSFSKKKKKNSEIVSFASGKSDIGFEERTDAGIAGKNMELSYNELEKYKYVKHIDSNNKYINNNNNSIHMSHMSSNNNTFESHIYFDAIKYQSSSLDEECLIYSSSFLGYRLVLRNKNTMCIEIDGSFNKWTIIGVNEFTNRRGKMSIVVKPDSMESGSILYVKGSDSSILSLLNLKYSKFLDKKYSRKRRNKNIQKYKQKREEYNELKSKDINIEEFQKSKSLSLKNFKNNTPKVLFGECTLDNNNNNINKNYKYDKNDKHNNNNNNNNNNSNYSYNYLHDSNNLDAMQNQKYSYAYEDKEDYYYTNNGECNKYKERYRRLEKQLRKFSVKGLRSMIFAFRYLSEEETIKYKRMYDDACSSIYNKEQRLEKVAEEFERDLIYLGITGVKNGLQEKVPKTIDILNQSGIRIWMLTGDNVEYSLHVSFLCKFLNKHTKIFHAALENSNAKKLKREGMALYELFQLEKEEKKPYENLCLLVNGRNLQTFLNYTDLQTHFLNMACTCDVVIACRITAKQKAFLVQLIKNRLYPTPNTLAIGDGANDIAMIQEANIGVSIMTSDCIISAGYSDYCIKKFCYLRKLLFIYGSKHLYTISIILYWNFFKNILLILPIFFYQAYASWSCVKIYPELLYTFFSIFWVFIPIIYYMFLQHNLNYDILYNIPLFYALSRRRYNMNCFKFLPWIFEAIFYSMIIYFFAYAALKENSHLNNGEVITINTFGNICFIGCLLISILRLFLEGSLWSPSILITCFGCFLFVFFPSLLFICFAYLSNEYIREVFRQTFLWAPLYVLLILWFSTCIISYIFINFTKSILFPNIYNVVNHWLFEQYQEKHNKNKYIFSLSGKNKFLKLRKLGKKIKFKFKRNYSKKYDTNVIREHPLLHHTFKSEQDQNKCNEQFSKDPFISNSLLKSKNCKFKKDSSYSKSNIHVDEEQTYKGLKVVLSEQVVHAKENLVSFKNEKKNKNNKNTSMNVNDNIIIKNNNINIKNNDNNNDDNDNDNNNNNNNNDNYNNNDHNKKEFKQKHIQNNYENLFNHTQVENNLIKENLSIRNDNNRRDNKNETDYIKQSDEDYEMNPSITSLRKRECINDSKYIDNKSYDNKISNNHEEKDGFKSDDRSLINSNMMDYKNEFTENDTTYSFNDSHMFYDFPSNSKTTKDYKVINSRIDDSIMADMKNCLNPLKNTFLVDLLPPGKRFRINEDHIYFKNNERMENIPEALDVNKKYYHIIQNKAEYYDNDSLSEFSYTSSNSSINNKKKNENTQKEIVKVSHLINRFTLAFKDMQLESGFQIHKKNKFYKTFTPWYRFIFLLLGVFFLYVWKLESSLSQLWNMPSDASTDVFILFLSLLLELVLLAATVTTFFSNIFIENFNKIISAVVILIITYHVVSYSVTHIDGVFQAVLFPLYTFVILRLPFVNAVLCNIIFLGLFIIRFNGDHFLDKKGLAHYIPLFIGVDVFVGFVGYRLEYNQRKNFLLEYSVESSRRKQREILNTMLPPFVVDEMIYSELNEEGIPISLKAEDISTVTIIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFETYLAACGLVKREKDEDELENNKYSNNNKNNNNNYYYNRKKKKKKNNNNNNNNNNNNNNNNNNNNNLNNNNNNNNVNTSDDDGDFFEEDDANNHQIYNQMKGQEDAHDSIDFALSILHVSSHIKYEKSKMMLKKNDSFEDANDDTHNVNDSFNNDKAENDNTNTDNNKPTRIRVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDDKTLIYEKKETEIKGKGIMTTYLLTSVIGLNYPFLGEHVEKKGHFISELYEDDLSNNLNYDKTQNILGYYSNKINQNNDSNINEGIINNNMNTFNTIDGDTSNYYVNLKDLSLNDLPNEYIKDVNTHYCEIIKLRNLKIGTAVGYQLKQKDFYNMTFLNNGLNNDTATNFNQYIESHKDFDDIKDLRIGMNKLSISDSLYYLNENVIRNEPINEYKNKIKINSVNTNKKSYEDAHLNAGNIIYTNNEYPNGQNIEEDDDLLLTNHYNKTNVNNNNNNNIYDVSKELIEHNEEDYKNILMCSKRCKNCNETYCTPNDCNNNDHVYHVMYHRKLSNIKKNYLKNIRKDANIKKDIEKEELNKIHSNKKSFNFFYLFSYIFKIFPFIGKINKEEKKNKSYKKGEQDKSSKRIIALNSEWIFLKFSDKNLEAKYRAHFYSNKSNINSIEQALIIFLVTFVMQTLISSTVSIVFIDHKRATQTLHINYFAYWSVRSVYTFFGFVLWLLFHYRTRPEVSSLLNIKWMIFFLNLLFISAACVFSIAYLWAISETDQTTSYTIWMTNDTIEFFFYLVILHHNTGMLFQTCILVDLLFITMSLTFIATSVVKTITTDSTVLLIPWYVAFNLISTYCKESIDRRTFYANESAKKTENRATELLNDMLPKHVLEEFQQDKLKLAYTHDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVAISEPVTEDNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLMESNGIPGKINVSETLKNFLLQQFKNRFIFKPHTTIRVIYKDVKCFIITDKKEVESSNHSKLLQNKNYLLNKKFSTQNYLVKNIFAKKKHSSISSSKNIHSYDEKKKKKNDLFYINVNDRQSNL
What is the function of this protein?
Catalyzes the synthesis of the second messenger cGMP from GTP (Probable).  In asexual blood stage schizonts, required for cGMP production which is essential for PKG activation, PKG-dependent Ca(2+) release, and ultimately merozoite egress from host erythrocytes (PubMed:33500341).
What are the official names of this protein?
Guanylate cyclase alpha, PfGCalpha, Guanylyl cyclase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=In gametocytes, localizes to the cell membrane and/or the parasitophorous vacuole membrane.