PharMolix/UniProtQA huggingface dataset:
Protein: CH602_ERYLH
Sequence: MAAKDVKFGRDAREGILKGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELKDKYENMGAQMLREVASKTNDLAGDGTTTATVLGQAIVREGMKSVAAGMNPMDLKRGIDIAVTKVVENLKSRSKDVAGSEEIAQVGIISANGDREVGEKIAEAMEKVGKEGVITVDESKGLEFELETVEGMQFDRGYLSPYFITNPDKMTVELENPYILIHEKKLSNLQAMLPILEAAVQSGRPLLIIAEDIEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEMISEDLGIKLENVTLGMLGEAKRVTIDKDNTTIVDGAGDEADIKARVNEIRTQIDNTTSDYDREKLQERLAKLAGGVAVIKVGGASEVEVKERKDRVDDALHATRAAVEEGIVPGGGTALLYATKVLEGLKGENDDQTRGIDIVRKAIVAPVRQIATNAGHDGAVISGNLLREDNESQGFNAATDTYEDLVKAGVIDPTKVVRVALQDAASVAGLLITTEAAISEVPEDKSSGGGMPDMGGMGGMGGMGGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGAP2_VIBCH
Sequence: MKWFKYGDGMDLFADMRQEAAGEKERVVMHSQEPWCVLLVDDDEQMHQITRLALTGFKFQNRPLELISVLSGLEARKVMAERSDIALALVDVVMETEHAGLDLVRYIREELQNRQVRLVLRTGQAGQAPEDRVIKEYEIDDYKEKTELTTQKLRTLLYSMLRAYRDLCLIEDQKLGLSHVIEASANVQNTKSLQSYATAVLNQLTSLLKLHASAFYCVATPCPDSEKCNALTVATTAERVELYVESPFKGLPEDVQRRCKEVLSQRTTRDYGDAYVFFKQDERGVDSVLYVGFEQELSELDRKLLEIYMYNIGLTFENINLMVDLRETSKELVYNLANAVEARSRETGAHVQRVALYCERLAHLYGLAESEADMIKNASPLHDVGKVAIPDSILHKPGKLDAQEWAIMQKHVEYGVEILNRSKRRLMQVAKEIAATHHEKWDGSGYPNRLQGDDIPISGRITAIADVFDALGAKRSYKDPWTDEQIREELMAQKGRHFEPKLVELLLEHWDEFIAIRASLPD
What is the function of this protein?
Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG (PubMed:25837739, PubMed:30365951).  Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels.  Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo.  Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation.  Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs) (PubMed:25837739).  Is also able to hydrolyze c-di-GMP but not c-di-AMP (PubMed:25343965, PubMed:25837739).
What are the official names of this protein?
3'3'-cGAMP-specific phosphodiesterase 2, 3'3'-cGAMP PDE 2, V-cGAP2.
Protein: TETM_STAAM
Sequence: MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPLYHGSAKSNIGIDNLIEVITNKFYSSTHRGPSELCGNVFKIEYTKKRQRLAYIRLYSGVLHLRDSVRVSEKEKIKVTEMYTSINGELCKIDRAYSGEIVILQNEFLKLNSVLGDTKLLPQRKKIENPHPLLQTTVEPSKPEQREMLLDALLEISDSDPLLRYYVDSTTHEIILSFLGKVQMEVISALLQEKYHVEIELKEPTVIYMERPLKNAEYTIHIEVPPNPFWASIGLSVSPLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLTPIVLEQAFRKAGTELLEPYLSFKVYAPQEYLSRAYNDAPKYCANIVNTQLKNNEVIIIGEIPARCIQDYRNDLTFFTNGLSVCLAELKGYQVTTGEPVCQTRRLNSRIDKVRYMFNKIT
What is the function of this protein?
Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
What are the official names of this protein?
Tetracycline resistance protein TetM, TetA(M).
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. TetM/TetO subfamily.
Protein: GPMB_ECO81
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVATRAKELGITHIISSDLGRTRRTAEIIAQACGCDIIFDSRLRELNMGVLETRNIDSLTEEEENWRRQLVNGTVDGRIPEGESMQELSDRVNAALESCRDLPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRVDYQESLWLASGWVVETAGDISHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: AB5F_ARATH
Sequence: MGLSTNLHSLDLRSTFFTGLRTSPIPSNFIKISSISNPRRDISTIRAQVSTISLETSVKQRQDEIESLFSKQPSQQDSDRKRNGKSSKNGASGISSGVKLENIRKSYKGVTVLKDVTWEVKRGEKVGLVGVNGAGKTTQLRIITGQEEPDSGNVIKAKPNMKVAFLSQEFEVSMSKTVREEFMTAFKEEMEITEKLEKVQKAIEGSVDDLDLMGRLLDEFDLLQRRAQAVNLDSVDAKISKLMPELGFAPEDADRLVASFSGGWQMRMSLGKILLQDPDLLLLDEPTNHLDLDTIEWLEGYLQKQDVPMVIISHDRAFLDQLCTKIVETEMGVSRTFEGNYSQYVISKAEWIETQNAAWEKQQKDIDSTKDLIARLGAGANSGRASTAEKKLEKLQEQELIEKPFQRKQMKIRFPERGTSGRSVVNVKNIDFGFEDKMLFKKANLSIERGEKIAILGPNGCGKSTLLKLIMGLEKPVKGEVILGEHNVLPNYFEQNQAEVLDLDKTVLETVCEAAEDWRSDDIKGLLGRCNFKADMLDRKVSLLSGGEKARLAFCKFMVTPSTLLVLDEPTNHLDIPSKEMLEEAINEYQGTVIAVSHDRYFIKQIVNRVIEVEDGCLEDYAGDYNYYLEKNLDARTKELEREAELEEKAPKVKAKSKMSKAEKEARKKQKMQAFQQAKQKSKASKNSKRWN
What are the official names of this protein?
ABC transporter F family member 5, ABC transporter ABCF.5, AtABCF5, GCN20-type ATP-binding cassette protein GCN5.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily.
Protein: GMHA_HELPH
Sequence: MIDDLIQKEFLAHKEALEKSLESLQEALKQSVHLLIETLENQGKILICGNGGSASDAQHFATELTGRYKLERKGLSAISLNTDTSALTAIANDYGYEEVFARQVEALGVKNDVLIGISTSGNSKNVLKAYEKAKDLGMKTLSLAGRDGGKMKPLSDMALIVPSDDTPRIQEMHILMIHILCDCIERHFAHKN
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSS_HAEIN
Sequence: MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKDEAGQEILDEIYRVKQENPHLDVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDDPNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVYLHQFEKYRYDRYQKITHAELADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNVLSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEIIVGDKVANDFYIPPEQPFKMAGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTYHLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQLLAQVEKEQNQIRQHTKVLKHYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL
What are the official names of this protein?
CDP-diacylglycerol--serine O-phosphatidyltransferase, Phosphatidylserine synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BTBDI_HUMAN
Sequence: MCSPASPKILYRNPRFLRLAFLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESSPELVEKEPMLAIDCREPYAFDTALLEQPCEAEEYRITSAAATSELEEILDFMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDMELWPRELTELEKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKLLHVSSLDTPQRSYGDLSPPCSNWVETGLEVSLTTDELLYPSPKAGKEVSGHSELLGSLPASSEEEEIDVVDWTAEGRLVPTTVPSVWPDPSSESETEVDILT
What is the function of this protein?
Specifically required during spermatogenesis to promote expression of piRNA precursors.  The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.  Acts by facilitating transcription elongation at piRNA loci during pachytene.
What are the official names of this protein?
BTB/POZ domain-containing protein 18.
What are the subcellular locations of this protein?
Nucleus.
Protein: P29_ECHGR
Sequence: MSGFDVTKTFNRFTQRAGELVNKNEKTSYPTRTSDLIHEIDQMKAWISKIITATEEFVDINIASKVADAFQKNKEKITTTDKLGTALEQVASQSEKAAPQLSKMLTEASDVHQRMATARKNFNSEVNTTFIEDLKNFLNTTLSEAQKAKTKLEEVRLDLDSDKTKLKNAKTAEQKAKWEAEVRKDESDFDRVHQESLTIFEKTCKEFDGLSVQLLDLIRAEKNYYEACAKECSMMLGE
What are the official names of this protein?
Hydatid disease diagnostic antigen P-29.
Protein: RS5_NEIG1
Sequence: MAKHEIEERGDGLIEKMVAVNRVTKVVKGGRIMAFSALTVVGDGDGRIGMGKGKSKEVPVAVQKAMDQARRSMIKVPLKNGTIHHEVIGRHGATKVFMQPAKEGSGVKAGGPMRLVFDAMGIHNISAKVHGSTNPYNIVRATLDGLSKLHTPADIAAKRGLTVEDILGVNHG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: COX18_YEAST
Sequence: MLKRLANRQNGFASFSCSSVGLRYGRTNPSTKRSFSLFQSVADTFLTVHEASHIPWIVLVPLTTMTLRTLVTLPFSIWQRRRILKQQELRKLVQPITPIIKLRLAAVTNKKSRNAARISSNGSFMPLQLQNAGVLTPEQITLLAVKETRKRQKKLFKKYNVPLWKNALLPMVQIPLWVTVSMGIRTLTETQLIESFYPSWFSALGFSSFDLSSPLVAMPLLAPILVGTLAVLNVELNGRLMFSSSLSSQGIKTISRNSTRVQEAMTSILNVSRLGCVVMLAMSSQAPFLLSLYWISSQLFSLVQNIILNWIYPYQR
What is the function of this protein?
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane.  Essential for the activity and assembly of cytochrome c oxidase.  Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX18, mitochondrial, Cytochrome c oxidase assembly protein 18.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL33_NITEC
Sequence: MREKIKLESSAGTGHFYTTTKNKRANPEKLELKKFDPVARKHVMYKETKLK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SURE_BACFN
Sequence: MENKRPLILVSNDDGIMAKGISELIKFLRPLGEIVVMAPDAPRSGSGCALTVTQPVHYQLLKKDVGLTVYKCSGTPTDCIKLARNQILDRKPDLVVGGINHGDNSATNVHYSGTMGIVIEGCLNGIPSIGFSICDHAPGADFDAAGPYVRRIAAMVLEKGLPPLTCLNVNFPNTQEIKGVRICEQAKGHWSGEWQACPRRDDANFYWLTGEFIDHEPENEKNDHWALANGYVAITPTVVDMTAYHFMDELKSWEL
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_DEIGD
Sequence: MQTLKAKYNEQVRPALMQQFGYSSIMAVPRIEKIVINEGLGSSKDDSKAIDKAAKELALITLQKPVITKAKKSISNFKLRQGMPVGVKVTLRGERMYVFLEKLINIGLPRIRDFRGINPNSFDGRGNYNLGIKEQLIFPEITYDMVDKVRGMDITIVTTAKTDEEARALLQAMGLPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: UVRB_DECAR
Sequence: MSETNTGTPVVTFEGSPYRLHQPFPPAGDQPEAIRQLVEGLDDGLSFQTLLGVTGSGKTYTMANVIARTGRPALVLAPNKTLAAQLYSEFKEFFPENSVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINDHIEQMRLSATKSLIERRDVVIVATVSCIYGIGDRDEYHNMILTMRVGDKLDQRAIVKRLTDMQYERNEMDFHRGTFRVRGDIIDIFPAEHAEHAIRISLFDDEVEGMQFFDPLTGHLLHKALRFTVFPASHYVTPRATVLRAVEAIKDELRERIDFFTRNNKLVEAQRIEQRTRFDLEMLDQIGFCKGIENYSRHFSGRKAGESPPTLIDYLPPDALMFIDESHVSIGQVGGMYKGDRSRKENLVDYGFRLPSALDNRPLQFNEFEAHMRQTIFVSATPADYEQQHAGQVVEQVARPTGLIDPEVIVRPASTQVDDLLAEIGKRIAVGERVLVTTLTKRMSEDLTDFLADNGIKVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHIHGTAILYADTVTQSMQRAIAETGRRREKQIAFNLEHGITPRGVSKKIKDIIDGVYDAGSAQTELKAAQQRAAYDAMDEKAVAREIKRLEKSMMECAKNLEFEKAAAARDDLFRLRERVFGAAQHDLDGDGTK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_HAES1
Sequence: MENTVQNKPIIELRSLTKSYDTKTIINNFNLTINNGEFLTILGPSGCGKTTVLRLIAGFEELNEGRIILDGEDVTDIPAERRHINTVFQSYALFPHMTIFENVAFGLRMQKVPNADIKPRVMEALRMVRLEEMADRKPTQLSGGQQQRVAIARAVVNKPKVLLLDESLSALDYKLRKEMQNELKALQRQLGITFIFVTHDQEEALTMSDRIIVMNKGTIQQDGSPRDIYEDPKNLFVAKFIGEINIFDAIVIERTDEKTVKANVEGRVCDIHTELTVQPNQKLKILLRPEDIIIEELDENESSKAIIGHVVDRSYKGMTLESSIILDHNKMKVLVSEFFNEDDPHIDHSVGQKVALTWHEGWEVVLDDEDEQ
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYT_LACPL
Sequence: MASINVKFPDGAEKQFDAGVTTEAIAKSISPSLAKRSVAGKFNDQIVDYRQPLTTDGSIEIIAADSEDGLNVLRQTAAQVLANAVKQLFPNIHFGSGEGNANGFFFDTDNPDEDGKQVSEDDLEAISDKMAAIIKQDLPIEREVLSKADALALVGDNPYQQDLVNERAAANNDQVVVYKQGDFVDLSDGAQLASTGKVKVFKLLSVAGAYWQGKSSNPMLQRIYGTAFLKQKDLDADLKRRQEARERDHRVIGNELDLFFVDPKVGNGLPYWMPNGATIRRQIERYIIDKEVANGYQHVYTPVLANLDVYKQSGHWDHYREDMFPPMDMGDGEQLELRPMNCPSHIQIYNHHIRSYRELPLRIAELGMMHRYEKSGALTGLSRVREMTLNDGHTFVALDQIEEEFKKILSLMVEVYEDFDISDYRFRLSYRDPENKEKYFDDDAMWERSQKMLKSAMDDMGLDYFEAEGEAAFYGPKLDVQTKTALGGEETLSTIQLDFLLPERFDLKYVGADGEEHRPVMIHRGLVSTMERFVAYLTEIYKGAFPTWLAPKQVTIIPVNNGAHGAYAETVRRRLAAEGVRVSIDDRNEKMGYKIRESQTKKVPYLLVVGDQEVANGSVSVRKYGEERTESEAVDMFIGAITQEIKHYSRGASK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_CLAMS
Sequence: MPKQKTHSGAKKRFKVTGSGKIMKQQAGMRHNLEVKSSKRKARLNQDQPLAKADMKVAKKLLGR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: VPX_SIVVT
Sequence: MASGRDPREARPGEVEIWDLSREPWDKWLRDMLQDLNQEARLHFGRELLFQVWNYCQEEGERHGTPMMERAYKYYRLVQKALFVHFRCGCRRRQPFEPYEERRDGQGGGRANRVPPGLE
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: WTR14_ARATH
Sequence: MALKTWKPFITVVSLQFGYAGLSIIAKFALNQGMSPHVLASYRHIVATIFIAPFAYFLDRKIRPKMTLSIFFKILLLGLLEPTIDQNLYYTGMKYTSATFTAAMTNVLPAFAFIMAWIFRLEKVNVKKIHSQAKILGTIVTVGGAMLMTVVKGPLIPLPWANPHDIHQDSSNTGVKQDLTKGASLIAIGCICWAGFINLQAITLKSYPVELSLTAYICFLGSIESTIVALFIERGNPSAWAIHLDSKLLAAVYGGVICSGIGYYVQGVIMKTRGPVFVTAFNPLSMVIVAILGSIILAEVMFLGRILGAIVIVLGLYSVLWGKSKDEPSSSFSDMDKELPLSTPQIVLPSKANAKMDTNDASVVISRPNTNESV
What are the official names of this protein?
WAT1-related protein At2g39510.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EF2_METPE
Sequence: MARGKKMVDRVSELMSQPKFIRNIGIVAHIDHGKTTLSDNLLSGAGMISEELAGRQLFMDSDAEEQARGITIDASNVSMVHEYEGQEYLINMIDTPGHVDFGGDVTRAMRAVDGAVVVVDAVEGTMPQTETVLRQALKEQVVPVLFINKVDRLINELKVDEMEMQVRLAKVIDKVNKLIKGMNEDMYNNGWKLDAAKGTVAFGSALYNWAVSAPFMQKSGVSFKDVYNKCREGDMKSLAKSSPLHAVLLDMVVKHLPDPFDAQKRRINVIWHGDKESVEGKSMLTADPNGPIAMMVTDISFDPHAGEVATGRLFSGTLRRGTELYIIGSAMKANRVQQVGIFMGPTRVEVEELPAGNIAAVTGLKDAIVGSTVTNLREMVPFEALTHYSEPVMTVAVEAKNMKDLPKLVEVLRQVAKEDPTLVITINEETGEHLISGMGELHLEIITGRIKRDKGVEIVTSEPIVVYRETATRKAGPIEGKSPNRHNRFYVELEPLDQVIVDLIRNGEVSMNQTWIERRDILVANGWEKDEAKNIKDISTTNIFIDMTKGVQYLNETMELILEGLHEALQGGPLADEPVQNMKIRLVDVKLHEDAIHRGPAQVIPAVRSAVKAGILYAGDSLLEPIQKISITVPTDQMGNATSQIQGRRGSVLDITSEGDTITVVGRVPVAELFGFSGDIRSATEGRAMWNTEFAGFEIVPNSLVKDVVIAIRKRKGLKEQMPRPEDYLA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBS_PORAE
Sequence: MRLTQGTFSFLPDLTDAQIQKQVQYAVSKKWAVSVEYTDDPHPRNSFWELWGLPLFDVKDASALMYEIAACRKAKPNYYIKVNAFDNTRGVESCCLSFIINRPINEPGFHLERQEVQGRNILYTIKSYAVNKPEGSRY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROQ_THENN
Sequence: MKLLVVNGPNLNMLGKRDRNVYGNFTYDDLVRMIEDWAKRNGVEVEVFQSNHEGEIIDRLHRLDFDGLVINPGAFTHYSYAIRDALEIVKVPKVEVHISNIHGREEFRRKSVTAEVCDGQISGLGAYGYILALEYVRKVSSESSK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SSP1B_CAEEL
Sequence: MTELKFKGVYVEDIGHLTCGTLTLTENSINFIGDKGGKSVYITGTDVDKLKWQKLGNKPGLRVGLSDGGAHRFGGFLDDDLQKIQSFTSSNWSKSINQSNLFINGWNYGQADVKGKNIEFSWENEPIFEIPCTNVSNVIANKNEAILEFHQNEQSKVQLMEMRFHMPVDLENEEDTDKVEEFKKAVLAYAGLEAETEQPICLLTDILCTTPRGRYDIKVYPTSIALHGKTYDYKIPVKTINRLFLVPHKDGRQVYFVLSLNPPIRQGQTHYSYLIFEFGKDEEEDLELSLTDEQLDYFNGNLQREMTGPIYETISILFKSICNLKVTVPGRFLGSSGTPAIQCTHRQNLGLLYPMEKGFLFIQKPVMYIRFEEISSCHFARSDSGTVTRTFDFEIDLKTGSSLTFSAMDKEENNKLFDYLNKKEIKIRNSHRIDNKSAGYGSSDEDDIDPYKSTVKAEGREQDDDSDDESTDEDYDLDKDMKKQKNDKDSSEGSGSEPDDEYDSGSEKDASGTGESDPDEENIEPKKKESKEKKNKREKKEKPVKEKAVKKGKKTKDPNEPKRATTAYIIWFNANRNSMKEDGDTLGDVAKKAGAKWKSMSADDKKEWNDKAAQDKARYEAEMKEYKKNGGGVEKASGPSTKKSSDQSPGKQFKSKEHISDTDDSDDDEPLKAKKDESDAASESSGESD
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.  Binds specifically to double-stranded DNA (By similarity).  In embryos, may function redundantly with hmg-4 to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114).  In the germline, acts non-redundantly with hmg-4 to play a role in oocyte development (PubMed:30336114).
What are the official names of this protein?
FACT complex subunit ssrp1-B, Facilitates chromatin transcription complex subunit ssrp1-B, HMG box-containing protein 3, Structure-specific recognition protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PANB_SALNS
Sequence: MKPTTISLLQKCKQEKKRFATITAYDYSFAKLFADEGINVMLVGDSLGMTIQGHDSTLPVTVEDIAYHTRAVRRGAPNCLLLSDLPFMAYATPEQACENAAIVMRAGANMVKIEGGAWLVDTVKMLTERAVPVCGHLGLTPQSVNIFGGYKIQGRGDAGQVLLDDALALEAAGAQLLVLECVPVELAKRVTEALSIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDMRAAVQQYMAEVESGVYPGEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_SHEB8
Sequence: MSTNPKPAFRRILLKLSGEALMGDEGFGIDPKVLDRMAQEVKELVELGIQVGVVIGGGNLFRGEGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLKGVCDDYNWAEAISLLKSGRVVIFAAGTGNPFCTTDSAACLRGIEIEAEVVLKGTKVDGVYSEDPMKNPDAVKYDEVTYAEILEKELKVMDLAAFTMARDHDMPILVFNMNKPGALRRVIMGEEEGTLIRAKKVI
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.