PharMolix/UniProtQA huggingface dataset:
Protein: HEPH_RAT
Sequence: MKAGHLLWALLLMHSLCSLPTDGAIRNYYLGIQDIQWNYAPKGRNVITNQTLNNDTVASSFLKSGKNRIGGTYKKTVYKEYSDGTYTNEIAKPAWLGFLGPLLKAEMGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWSIPEGHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGPFQDSNRMHAINGFVFGNLPELSMCAQKHVAWHLFGMGNEIDVHTAFFHGQTLSIRGHRTDVAHIFPATFVTAEMVPQKSGTWLISCVVNSHLKSGMQAFYKVDSCSMDPPVEQLTGKVRQYFIQAHEIQWDYGPIGHDGRTGKSLREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERLHQEEETHLGILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKSSEGTVYNDGTSYPKVAKSFEKVTYYWTVPPHAGPTAEDPACLTWMYFSAADPTRDTNSGLVGPLLVCKAGALGEDGKQKGVDKEFFLLFTIFDENESWYNNANQAAGMLDSRLLSEDVEGFEDSNRMHAINGFLFSNLPRLDICKGDTVAWHLLGLGTENDVHGVMFEGNTLQLQGMRKSAAMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREAGMQAIYNVSQCSSHQDSPRQHYQASRVYYIMAEEIEWDYCPDRSWELEWYNTSEKDSYGHVFLSNKDGLLGSKYKKAVFREYTDGTFRIPQPRSGPEEHLGILGPLIRGEVGDILTVVFKNKASRPYSIHAHGVLESSTGWPQAAEPGEVLTYQWNIPERSGPGPSDSACVSWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGGRNDMDREFALLFLIFDENQSWYLKENIATYGPQETSHVNLQDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQDTDIHTVHFHAESFLYQNGHSYRADVVDLFPGTFEVVEMVASNPGAWLMHCHVTDHVHAGMETIFTVLSHEEHFSTMTTITKEIGKAVILQNIGEGNVKMLGMNIPVKNVEILSSALIAICVVLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ
What is the function of this protein?
May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis.  Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1 (By similarity).
What are the official names of this protein?
Hephaestin.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DER_PECCP
Sequence: MIPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGHEFIIVDTGGIDGTEDGVETRMAGQSLVAIEEADIVLFMVDARAGLMPADEGIAKHLRSREKTTVLVANKTDGLDPDMVTADFYSLGMGEVYPIAASHGRGVTSLLETVLLPFVQDEIEEPVELSEEEENAAYWAALEADEQASEEEAEDDFNPEDLPIKLAIVGRPNVGKSTLTNRILGEERVVVFDMPGTTRDSIYIPMVRDEREYVLIDTAGVRKRGKVTETVEKFSVIKTLQAIEDANVVLLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVREQVKETLDLRLGFIDFARIHFISALHGSGVGNLFESVTEAYACATRRVSTAMLTRIMQMASDDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYYRRSLDVMGTPIRIQFKEGENPFADKRNTLTPNQLRKRKRLMSHIKKGK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: METE_VIBVY
Sequence: MTTTTHILGYPRIGEKRELKFAQEKYWRGEIDQAELKKVGAELRYKNWQTQASAGLSFAVAGDFAWYDHVLTTTLLLGHVPKRHRHGFPDLDTLFRVGRGQSQSSCACHGAAASDMTKWFNTNYHYIVPEFSKEDTFEVSWPQLFEEVNEAVQAGHKVKPVLLGPLSYLYLGKEIEDGFDRLTLLPRLLTAYQAILAKLAKQGVEWVQIDEPILALELEKPWLDAFKLAYQVIRSDVKVLLTTYFDSVVDSLDRIVELSVDGLHVDLSAAPEQLDAVLAKLPQNWVLSLGVVNGRNVWRSDVKAQLERLQPVKAALGERLWVASSCSLLHSPVDLELEAGLSAEVRSWFAFAKQKVSEVVLLGKALDGDAASIAQCEAYSQPIQARKSAAHVHKATVQSRVNAITAELAQRSVPYAERARHQAEVLQLPLLPTTTIGSFPQTSEIRVQRSAYRSGQLSSAEYEQALKGHIADAVKRQEALDLDVLVHGEAERNDMVEYFAEHLAGFQTTQFGWVQSYGSRCVKPAIVVADIEREQPITVGWSTYAQSLTSKQMKGMLTGPVTILCWTFPREDISRKAIAQQLALALRDEVSDLQDAGINIIQIDEPAIREGLPLKKRDHQNYLDWALEAFRISAASARPETQIHTHMCYSEFNEIIESVAALDADVITIETSRSNMELLKAFEEFNYPNEIGPGVYDIHSPNIPSEEWIVDLVKKAAQKIPVERLWVNPDCGLKTRNWPETEAALANLVSAAKRLRKEFAKETTAVNSDALAKVETEA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: AZOR1_HALH5
Sequence: METLFVKANDRENSVTGLLYEAFISTYKALNPNDSIVELDLFQEHMPYLNALMIEVNYKAAQGIPLPTSEEEVDHIVKRHLNQFLAADKIVFAFPLWNLTVPAVLHTYLDYLHHPRKTFTYTEEGLVGLLPNKKVALLNARGGVYAEDDRSEMAVSFVKNHLNVFGITDITTVIIEGHNQFPDRSETIIQKGLQKAKQVAKTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: CH602_BURPS
Sequence: MAAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEIELADKVQNIGAQLVKEVASKTSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGIDKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQRIAEAIDRVGKEGVITVEDGKSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQVAKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQVITEETGLTLEKATLQELGRAKRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDYDREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALIRVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNAATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAGGPGFDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUD_PECAS
Sequence: MQLRQASVLPRLSPTNAECRPGELLHIIGPNGAGKSTLLARAAGLLAGEGEVYLAGTPLSQYTAADLAVRRAYLAQQQPPLALMPVFQYWQRHQPPLAQEYAVEKVVHFLAERLMLTDKLARPLTQLSGGEWQRVRLVAALLQIWPTINPHARLLLLDEPTNSLDVAQQVALDSLLSELCRLGIAVVVCAHDLNHSAHHADRVWLLSAGVLVAQGETEDVMLPEVLSPVFGVAFQRHVVDGRNWIITRSA
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNS10_MOUSE
Sequence: MKVTLVHLLFMMLLLLLGLGLGLGLGLHMAAAVLEDQPLNEFWPSDSQNTEEGEGIWTTEGLALGYKEMAQPVWPEEAVLSEDEVGGSRMLRAEPRFQSKQDYLKFDLSVRDCNTMMAHKIKEPNQSCINQYTFIHEDPNTVKAVCNGSLVDCDLQGGKCYKSPRPFDLTLCKLAKPGQVTPNCHYLTYITEKSIFMTCNDKRQLETK
What is the function of this protein?
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility.  May be involved in sperm adhesion to the egg zona pellucida.  Does not have ribonuclease activity.
What are the official names of this protein?
Inactive ribonuclease-like protein 10, Protein Train A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: SLA1_YEAST
Sequence: MTVFLGIYRAVYAYEPQTPEELAIQEDDLLYLLQKSDIDDWWTVKKRVIGSDSEEPVGLVPSTYIEEAPVLKKVRAIYDYEQVQNADEELTFHENDVFDVFDDKDADWLLVKSTVSNEFGFIPGNYVEPENGSTSKQEQAPAAAEAPAATPAAAPASAAVLPTNFLPPPQHNDRARMMQSKEDQAPDEDEEGPPPAMPARPTATTETTDATAAAVRSRTRLSYSDNDNDDEEDDYYYNSNSNNVGNHEYNTEYHSWNVTEIEGRKKKKAKLSIGNNKINFIPQKGTPHEWSIDKLVSYDNEKKHMFLEFVDPYRSLELHTGNTTTCEEIMNIIGEYKGASRDPGLREVEMASKSKKRGIVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPVRDKKHTESTASGIIKSIKKNFTKSPSRSRSRSRSKSNANASWKDDELQNDVVGSAAGKRSRKSSLSSHKKNSSATKDFPNPKKSRLWVDRSGTFKVDAEFIGCAKGKIHLHKANGVKIAVAADKLSNEDLAYVEKITGFSLEKFKANDGSSSRGTDSRDSERERRRRLKEQEEKERDRRLKERELYELKKARELLDEERSRLQEKELPPIKPPRPTSTTSVPNTTSVPPAESSNNNNSSNKYDWFEFFLNCGVDVSNCQRYTINFDREQLTEDMMPDINNSMLRTLGLREGDIVRVMKHLDKKFGRENIASIPTNATGNMFSQPDGSLNVATSPETSLPQQLLPQTTSPAQTAPSTSAETDDAWTVKPASKSESNLLSKKSEFTGSMQDLLDLQPLEPKKAAASTPEPNLKDLEPVKTGGTTVPAAPVSSAPVSSAPAPLDPFKTGGNNILPLSTGFVMMPMITGGDMLPMQRTGGFVVPQTTFGMQSQVTGGILPVQKTGNGLIPISNTGGAMMPQTTFGAAATVLPLQKTGGGLIPIATTGGAQFPQTSFNVQGQQQLPTGSILPVQKTANGLISANTGVSMPTVQRTGGTMIPQTSFGVSQQLTGGAMMTQPQNTGSAMMPQTSFNAVPQITGGAMMPQTSFNALPQVTGGAMMPLQRTGGALNTFNTGGAMIPQTSFSSQAQNTGGFRPQSQFGLTLQKTGGIAPLNQNQFTGGAMNTLSTGGVLQQQQPQTMNTFNTGGVMQELQMMTTFNTGGAMQQPQMMNTFNTDGIMQQPQMMNTFNTGGAMQQPQQQALQNQPTGFGFGNGPQQSRQANIFNATASNPFGF
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein SLA1.
What is the protein family that this protein belongs to?
Belongs to the SLA1 family.
What are the subcellular locations of this protein?
Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches. Is associated with cortical actin patches in its dephosphorylated form and dissociates upon phosphorylation by PRK1.
Protein: RL31B_VIBCM
Sequence: MKAGIHPDYRKVVFHDTTVDHYFVVGSTLQTDRTIEWEGKTYPYITIEVSSESHPFYTGKQRVVQKEGRVANFTRRFGQFAKESK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RGA_ARATH
Sequence: MKRDHHQFQGRLSNHGTSSSSSSISKDKMMMVKKEEDGGGNMDDELLAVLGYKVRSSEMAEVALKLEQLETMMSNVQEDGLSHLATDTVHYNPSELYSWLDNMLSELNPPPLPASSNGLDPVLPSPEICGFPASDYDLKVIPGNAIYQFPAIDSSSSSNNQNKRLKSCSSPDSMVTSTSTGTQIGGVIGTTVTTTTTTTTAAGESTRSVILVDSQENGVRLVHALMACAEAIQQNNLTLAEALVKQIGCLAVSQAGAMRKVATYFAEALARRIYRLSPPQNQIDHCLSDTLQMHFYETCPYLKFAHFTANQAILEAFEGKKRVHVIDFSMNQGLQWPALMQALALREGGPPTFRLTGIGPPAPDNSDHLHEVGCKLAQLAEAIHVEFEYRGFVANSLADLDASMLELRPSDTEAVAVNSVFELHKLLGRPGGIEKVLGVVKQIKPVIFTVVEQESNHNGPVFLDRFTESLHYYSTLFDSLEGVPNSQDKVMSEVYLGKQICNLVACEGPDRVERHETLSQWGNRFGSSGLAPAHLGSNAFKQASMLLSVFNSGQGYRVEESNGCLMLGWHTRPLITTSAWKLSTAAY
What is the function of this protein?
Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway.  Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.  Positively regulates XERICO expression in seeds.  Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway.  Compared to other DELLA proteins, it is the most sensitive to GA application.  No effect of the BOI proteins on its stability.  Its activity is probably regulated by other phytohormones such as auxin and ethylene, attenuation of auxin transport delaying its GA-induced degradation.  Involved in the regulation of seed dormancy and germination, including glucose-induced delay of seed germination (PubMed:24989044).
What are the official names of this protein?
DELLA protein RGA, GAI-related sequence, GRAS family protein 10, AtGRAS-10, Repressor on the ga1-3 mutant, Restoration of growth on ammonia protein 1.
What is the protein family that this protein belongs to?
Belongs to the GRAS family. DELLA subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in the nucleus in response to cold.
Protein: SRP19_CANLF
Sequence: MACAAARSPAEQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076).  Binds directly to 7SL RNA (PubMed:6413076).  Mediates binding of SRP54 to the SRP complex (PubMed:6413076).
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Although the signal recognition particle complex acts in the cytoplasm, it assembles at least in part in the nucleus and/or the nucleolus. SRP19 nuclear import may be mediated by IPO8/Imp8 and TPNO1/Trn.
Protein: VF317_ASFM2
Sequence: MVETQMDKLGFLLNHIGKQITTKVLSNAHITQTMKEIILENNSVNVDGGAAKNVSKGKSPPKEKKHWTEFESWEQLSKSKRSFKEYWTERNEIVNTLLLNWDNVRAAIKKFLNDDREWCGRINMINGVPEIVEIIPSPYKAGENIYFGSEAMIPAEIYSRVANKPAMFVFHTHPNLGSCCGGMPSICDISTTLRYLLMGWTAGHLIISSNQVGMLTVDKRIIIDLWANENPRWLMAQKILDIFMMLTSRRSLVNPWTLRDLKKILQDYGIEYIIFPSNDFFIYEDVRLLMISKKWTNFFTLHELLNDLETIETKTSST
What are the official names of this protein?
Uncharacterized protein F317L, pF317L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus F317L family.
What are the subcellular locations of this protein?
Virion.
Protein: LYSJ_SULAC
Sequence: MKLIQLYGDRGLTIVKGEAQYVWDIEGRRYLDFHTGIGVAFLGHRNPIILEYLKNQLENISILSTSFSTPIKDEMLQALDKVKPDKMDNAMLLNSGTEAVEAALKTARKITGRKKIIAFKNAFHGRTAGSLSVTWNKKYREPFEPLVGPVEFLTFNNIEDLSKIDNETAAVIVEPIQGESGVIPANIEFMKALKEKTENTGSLLIFDEIQTGFGRTGKLWAYKHYNIVPDILTAGKAIGGGFPVSVVFLPDHIANKLEEGDHGSTYGGNPMAMAAVTAACKVIEKENVVEQANQKGQQFSNILVKNLADLKVVREVRGKGLMIGIDIRFQPGQVLKYLQEKGILAVKAGSTVIRFLPSYLITYENMEEASNVLREGLLKIENKAVSS
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
[LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTND_BACAH
Sequence: MAQIRIHEVNTRIENEVEVSKFLQEEGVLYEKWNISKLPPHLNENYSLTDENKAEILAVFSKEIADVSVRRGYKAHDVISLSNSTPNLDELLINFQKEHHHTDDEVRFIVSGHGIFAIEGKDGTFFDVELEPGDLISVPENARHYFTLQDDRQVVAIRIFVTTEGWVPIY
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: PSD_LAWIP
Sequence: MGKTNLGIDQEGFPYIAIFAFSSLIFAILGWWLLAVLCLIGTIFCGHFFRDPERIIPTEANIAVSPADGKIIRIEPRQDPISGESHTCISIFMNICNVHVNRSPIKGQIEAIQYVQGHFLNASLDKAAKENEHCSYLLRDQDGKQWVVVQIAGLIARRIVCRTKEGDILNRGERFGIIRFGSRVDLYLPEEYTPTVNLGNKVIAGETILAKKNQE
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PDE3B_RAT
Sequence: MRKDERERDTPAMRSPPPPPPPATATAASPPESLRNGYVKSCVSPLRQDPPRSFFFHLCRFCNVEPPAASLRAGARLSLAALAAFVLAALLGAGPERWAAAATGLRTLLSACSLSLSPLFSIACAFFFLTCFLTRAQRGPDRGAGSWWLLALPACCYLGDFAAWQWWSWLRGEPAAAAAGRLCLVLSCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGALPPALRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTADEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSSKPSFPTAQLRRSSGASGLLTSEHHSRWDRSGGKRPYQELSVSSHGCHLNGPFSSNLMTIPKQRSSSVSLTHHAGLRRAGALPSPSLLNSSSHVPVSAGCLTNRSPVGFLDTSDFLTKPSVTLHRSLGSVSSAADFHQYLRNSDSSLCSSCGHQILKYVSTCEPDGTDHHNEKSGEEDSTVFSKERLNIVETQEEETVKEDCRELFLEGDDHLMEEAQQPNIDQEVLLDPMLVEDYDSLIEKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLSSKSCCIPDKSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIEAEEGDDTESDDDDDDDDDDDDDDDEELDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEKCKAEGNKLQVDNASLPQADEIQVIEEADEEEEQMFE
What is the function of this protein?
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9631240).  Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity).  Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity).
What are the official names of this protein?
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, CGI PDE, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, RcGIPl.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: ICEK_PSESX
Sequence: MTLDKALVLRTCANNMADHCGLIWPASGTVESRYWQSTRRHENGLVGLLWGAGTSAFLSVHADARWIVCEVAVADIISLEEPGMVKFPRAEVVHVGDRISASHFISARQADPASTSTSTSTSTLTPMPTAIPTPMPAVASVTLPVAEQARHEVFDVASVSAAAAPVNTLPVTTPQNLQTATYGSTLSGDNHSRLIAGYGSNETAGNHSDLIAGYGSTGTAGYGSTQTSGEDSSLTAGYGSTQTAQEGSNLTAGYGSTGTAGSDSSLIAGYGSTQTSGGDSSLTAGYGSTQTAQEGSNLTAGYGSTGTAGVDSSLIAGYGSTQTSGSDSALTAGYGSTQTAQEGSNLTAGYGSTGTAGSDSSLIAGYGSTQTSGSDSSLTAGYGSTQTAQEGSNLTAGYGSTGTAGVDSSLIAGYGSTQTSGSDSALTAGYGSTQTAQEGSNLTAGYGSTGTAGADSSLIAGYGSTQTSGSESSLTAGYGSTQTAREGSTLTAGYGSTGTAGADSSLIAGYGSTQTSGSESSLTAGYGSTQTAQQGSVLTSGYGSTQTAGAASNLTTGYGSTGTAGHESFIIAGYGSTQTAGHKSILTAGYGSTQTARDGSYLIAGYGSTGTAGSGSSLIAGYGSTQTASYRSMLTAGYGSTQTAREHSDLVTGYGSTSTAGSNSSLIAGYGSTQTAGFKSILTAGYGSTQTAQERSDLVAGYGSTSTAGYSSSLIAGYGSTQTAGYESTLTAGYGSTQTAQENSSLTTGYGSTSTAGYSSSLIAGYGSTQTAGYESTLTAGYGSTQTAQERSDLVTGYGSTSTAGYASSLIAGYGSTQTAGYESTLTAGYGSTQTAQENSSLTTGYGSTSTAGFASSLIAGYGSTQTAGYKSTLTAGYGSTQTAEYGSSLTAGYGSTATAGQDSSLIAGYGSSLTSGIRSFLTAGYGSTLIAGLRSVLIAGYGSSLTSGIRSTLTAGYGSNQIASYGSSLIAGHESIQVAGNKSMLIAGKGSSQTAGFRSTLIAGAGSVQLAGDRSRLIAGADSNQTAGDRSKLLAGNNSYLTAGDRSKLTGGHDCTLMAGDQSRLTAGKNSVLTAGARSKLIGSEGSTLSAGEDSTLIFRLWDGKRYRQLVARTGENGVEADIPYYVNEDDDIVDKPDEDDDWIEVK
What is the function of this protein?
Ice nucleation proteins enable bacteria to nucleate crystallization in supercooled water.
What are the official names of this protein?
Ice nucleation protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial ice nucleation protein family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: TONB_YEREN
Sequence: MQLNKFFLGRWLTWPLAFSVGIHGSVIAALLYVSVEQMRIQPEIEDAPIAVTMVNIDTFAAPQPAAAEPQAEPEPEPEPEPEPIDEAPPEPEVLPEPVPVPIPEPVKPKPKPVKKEVKKPEVKKPDVKKTVAPPDDKPFKSDEPALVSTNAPVKSAPKASVPGVSTSTGPKALSKAKPTYPARALALGVEGQVKVQYDIDENGRVTNVRILEATPRNTFEREVKQVMRKWRFEAVAAKDYVTTVVFKIGGTTEMD
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: RPO3_THEVO
Sequence: MEVKIFKLSDKYMSFEIDGITPSQANALRRTLINDIPKLAIENVTFHHGEIRDAEGNVYDSSLPLFDEMVAHRLGLIPLKTDLSLNFRDQCSCGGKGCSLCTVTYSINKIGPASVMSGDIQAISHPDLVPVDPDIPIVKLGAKQAILITAEAILGTAKEHAKWQVTSGVAYKYHREFEVNKKLFEDWAKIKERCPKSVLSEDENTIVFTDDYGCNDLSILFESDGVQIKEDDSRFIFHFETDGSLTAEETLSYALNRLMDRWGILVESLSE
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC23_CANAL
Sequence: MDFEEAEDINGIRFAWNAFPSTKVEAGKVVVPTGALYTPLKQREDLPIAAYDPIYCSNQSCKSILNPYCAVDPNGFWRCPLCQYRNPLPAHYHGLNPENLPLELQSTSSTIEYITARPVQNPPIFTFVIDLCQDEDNLQALIEDIIVSFNYLPPNALIGLITFGTMIQVHDLGSDKINKSYIFRGDKEYTDKQISEMLNRPISTQLMQQQQQQPGQMNPQLANSLTRFFLPLEDVEFQLTSILENLSKDPWAVANGARPLRSTGSALNIAVNLLGLTYPGFGARVMLFAAGPCTLNPGMIVGNQLKEPIRSHSDIDKDNAKHFKKATKLYENIAAKAVKNCHTVDIFAGCYDQIGMLEMKNLCNLTGGTLLLTDAFTTSIFKRSFLRLFNKDDEGYLLMGFNGNLEVRTSKELKISGLIGNASSLQVKSANVSENELGLGGSSSYRLCSTSPRHTYAVFFDVVNNQQLPPNAQSYIQFITHYQHSSGTYRVRVTTVSNFLTSDEQTLTNSFDQEAAAVLMARITLFKAEQDDGADVLRWVDRMLIRLCQKFADYRKDQQESFRLGPQFQLYPQFIYYLRRSQFLQVFNNSPDETAFYRHVLLVEDTNNSLIMIQPTLTSFTLDGEPEAVLLDSVSIKDDRILLLDTFFHILIFHGKTISQWRKANYQDLPEYSNFKELLEFPKKEAAELLHDRYPLPRFIDTEEGGSQARFLYSKLNPSVTYNTNDFIGGGGAGGGAIVLTDDVSLQVFMSHLQKLVVSGSS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4052_BACC4
Sequence: MASETVANHQEKALALLQADAEKILRLIKVQMDHLTMPQCPLYEEVLDTQMFGLSREVDFAVRLGLIAEEQGKAMLGELERELSALHEAFTNKQQ
What are the official names of this protein?
UPF0358 protein BCB4264_A4052.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: MIC27_YEAS7
Sequence: MVNFYDDVDESKSHGEFPLIPVVLQNSSELSVRTIPTGNEIIESVHLTKWLRKYRNALASQLDRYEKGWQSKIANFRLQVQHVINYSRKNIFNVDSENKHTVVPGSLIALGAFFAGSIAVNRSNWGAKRLIFGHKSSILEKLCTSLPSRILLPWVLAAATFKYWAPQTSQNLVNATENDLLPADFVKSYHNTWKRIYEEGYVAKKCDLKRQIDQTLQKNIRYAREQLYEKLEQA
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
What are the official names of this protein?
MICOS complex subunit MIC27.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.