PharMolix/UniProtQA huggingface dataset:
Protein: MRM2_DROME
Sequence: MRLVFTGNCVFKRLLHTEIGGKYAKQQPRNLKGRSKSSQEWLTRQLADPYVEKARMMNYRCRSAFKLLEIDDKYGILRPGDTVLECGAAPGSWTQVAVERTNANGKQERAPQGAVFSIDLLHFHAVPGATIFGGMDFTSSLAQKRLREALQDRKVNCVLSDMAPNATGVRMLDQESITNLCYEVLRFALAMSAPQAHLVVKVWDNGDVPKLERDMLRFYEKVKRVKPRASRGDSAEHFLVARNFKGATDS
What is the function of this protein?
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
What are the official names of this protein?
rRNA methyltransferase 2, mitochondrial, rRNA (uridine-2'-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPB_CAMFF
Sequence: MIRIGIHGASGKMGYEIISNLKNNEQAILSVAYTIEPMPFDVGDAIVTNDLKTLFDNSDVIIDFSIKDGAVNLINYARTNPKPLIIGTTGLGSEGDELIKLASSVMPILQATNMSLGVAVLNRLTEFASRVLDGFDIEIVEMHHRRKVDAPSGTALTLATHAAKARNLTLDSVRVSGRDGMIGARSKDEIAVMSLRGGDIVGRHTVGFYNDGEFIELNHTATSRATFAKGAIKAAIWIKSKEPKLYSIYDCLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_CHLL3
Sequence: MSKIDKASRRQKIKDRSRFSVAGTQEKPRLCVYRSLSQIYAQLIDDSGKKTIMAVSSMSKENKELKGSKTEVCHRVGKQIAEKALANGITNVVFDRNGFRYHGRIKALADGAREAGLIF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: NDK_EHRRG
Sequence: MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFVPLINFMISGPVVVQVLEGENAISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDSLENAIREIRFFFSEYELLSLYEC
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_RICPU
Sequence: MANHSSAKKAARQTVKRTLINKKRSSAIKTFIKKVVHEISLGNKENANIALSVAQSKIMQGVKKNIIKLNTASRKISRLSRQIKSLKVNNTL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: GLO2_VIBA3
Sequence: MLHIKSIPAFNDNYIWLIQNSDRRCAVVDPGDAAPVLEYLAHHELTLDAILITHHHHDHIGGVPELVRQFPGVDVVGPKNEPIPTLTHPVDDGDQLELFGEVFLVLGLSGHTAGHIGYVGDAKLFCGDVLFSAGCGRIMEGTPQQMFDALNKITALPQETEVYCAHEYTAANIAFALAVEPDNQHLQQYRDQVNRLRAQNKSTIPTNLRQEKFINPFLRYTEPSVVKSVSNRTEQTDPLSVFTALRAWKNEF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: RLMN_BORPE
Sequence: MEAVERVNLLGLDGAALSELVGQWGGKPFRARQLQRWVHQRGADSFDAMTDLARDFRAQLARDCVIEALPVNTEQRSSDGTRKWLFDVGQGNAIETVFIPEDDRGTLCISSQAGCVVNCRFCSTGHQGFNRNLRASEIIGQLWWAKRVLEAAADTARLPGGKAGEDTRVISNVVMMGMGEPLLNYDQVLPALRLMLDDNAYGLSRRRVTVSTSGVVPMMDRLSQDCPVALAVSLHAPNDALRDELVPLNKKYPLNALLAACERYLAHAPRDFITFEYCMLDGINDTDQHARELIQLARQVRCKLNLIPFNPFPASGLKRSPSARVRVFAQRLMDAGIVTTVRKTRGDDIDAACGQLAGEVRDRTRITERNATRTIPIQQVHA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2LY_HUMAN
Sequence: MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLARSSPE
What is the function of this protein?
May have a transcription role in testis.  May act as a competitor/regulator of TGIF2LX.
What are the official names of this protein?
Homeobox protein TGIF2LY, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y.
What is the protein family that this protein belongs to?
Belongs to the TALE/TGIF homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KHSE_VIBPA
Sequence: MGVVVYAPASIGNVSVGFDVLGAAVSPVDGTLLGDRVQVKAGTEPFSLNTAGHFVSKLPTDPKENIVYDCWVVFARELDKKGIELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNRFHDQPLNETELLALMGEMEGKISGGIHYDNVAPCYLGGVQLMLEELGIISQEVPCFDEWYWVMAYPGIKVSTAEAREILPSQYRRQDIIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPYREKLLPGFANARQYAASAGALATGISGSGPTLFSICKQKDVAERVARWLEQNYVQNEEGFVHVCRLDKQGSKVTGSEL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISY_SYNY3
Sequence: MNYMMTDNEVFKEGLAGVPAAKSRVSHVDGTDGILEYRGIRIEELAKSSSFIEVAYLLIWGKLPTQAEIEEFEYEIRTHRRIKYHIRDMMKCFPETGHPMDALQTSAAALGLFYARRALDDPKYIRAAVVRLLAKIPTMVAAFHMIREGNDPIQPNDKLDYASNFLYMLTEKEPDPFAAKVFDVCLTLHAEHTMNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEEVLNMLEEIGSVENVRPYVEKCLANKQRIMGFGHRVYKVKDPRAIILQDLAEQLFAKMGHDEYYEIAVELEKVVEEYVGQKGIYPNVDFYSGLVYRKLDIPADLFTPLFAIARVAGWLAHWKEQLSVNKIYRPTQIYIGDHNLSYVPMTERVVSVARNEDPNAII
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: DCE1_RAT
Sequence: MASSTPSPATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFRERQASKNLLSCENSDPGARFRRTETDFSNLFAQDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIIGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEHSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGFVPLYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
What is the function of this protein?
Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
What are the official names of this protein?
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: MTSA_STRCR
Sequence: MKKCRFLVLLLLAFVGLAACSSQKSSTETGSSKLNVVATNSIIADITKNIAGDKINLHSIVPVGQDPHEYEPLPEDVKKTSQADLIFYNGINLETGGNAWFTKLVENAKKKENKDYYAVSEGVDVIYLEGQSEKGKEDPHAWLNLENGIIYAQNIAKRLSEKDPANKETYEKNLKAYVEKLSALDKEAKEKFNNIPGEKKMIVTSEGCFKYFSKAYNVPSAYIWEINTEEEGTPDQIKTLVEKLRKTKVPSLFVESSVDDRPMKTVSKDTNIPIYAKIFTDSVAEKGEEGDSYYSMMKYNLEKIAEGLSK
What is the function of this protein?
Part of an ATP-driven transport system for manganese.  Does not exhibit adhesion properties.
What are the official names of this protein?
Metal ABC transporter substrate-binding lipoprotein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: AROK_VIBVU
Sequence: MAEKRNIFLVGPMGAGKSTIGRYLAQQLHMEFLDSDTVIEERTGADISWVFDVEGEEGFRKREEAVINDLTLEQGIVLATGGGSVKSRENRNRLSARGIVVYLETTIEKQLARTNRDKKRPLLQTDNPREVLESLAGERNPLYEEIADYTVRTDDQSAKVVANQIVKMLEES
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPG3_HUMAN
Sequence: MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEYLSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAEPGPSSLGSMLMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLSFERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLSPKMPRTLSLHEITDLLETDDSIEASAIVIQPPENATAPVSDEESGDEEGGTINNLPGSLLHTAAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLTVQPVAGRVTAPPNDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEFKCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVADNANLDPVDKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCGATCLGYICWFQPYQGKNPNTKHEEYGVGASLVLQFSEALTEAHPGQYHFVFNNFFTSIALLDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVTVASSGAGIHPLCLVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGKKWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPEPGQKGRPQKRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE
What is the function of this protein?
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6.  Involved in the regulation of gene expression.  In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses.  This response is almost completely suppressed in the presence of ERCC6.  In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7.  In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.
What are the official names of this protein?
Chimeric ERCC6-PGBD3 protein, Chimeric CSB-PGBD3 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSLU_SHESH
Sequence: MSEMTPREIVHELDTHIIGQHDAKRSVAIALRNRWRRMQLDVDFRQEVTPKNILMIGPTGVGKTEIARRLAKLAKAPFIKVEATKFTEVGYVGKEVEQIIRDLTDSAIKMTREDQMKKCKFKAEEAAEERILDALLPKPKEDWDNEKPDDSATRQIFRKKLREGQLDDKEIEIDVAAPQVGIEIMSPPGMEEMTNQLQSMFQNMGPGDSKRRKMPIKEAYKLMIEEEAAKLVNQDDMKEQAIELVEQHGIVFLDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVNTKHGMVKTDHILFIASGAFQMSKPSDLIPELQGRLPIRVELSALTADDFKRILTEPHASLTEQHVAMMGTEDVKIEFTEDGIESIAQAAWQVNERTENIGARRLHTVMERLMEDLSYDASDKSGNTFVIDAEYVSSHLDDLVQDEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MREB_SALTY
Sequence: MLKKFRGMFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVAAVGHDAKQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDMHGGDLFSEE
What is the function of this protein?
Forms membrane-associated dynamic filaments that are essential for cell shape determination.  Acts by regulating cell wall synthesis and cell elongation, and thus cell shape.  A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
What are the official names of this protein?
Cell shape-determining protein MreB.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Membrane-associated.
Protein: Y258_HAEIN
Sequence: MTDRQTDRQTDRQTDRQTDRQTDRQTDRQTDGRTVSQTMNIIFSSDHYYAPYLAVSIFSIIKNTPKKINFYILDMKINQENKTIINNLASAYSCKVFFLPVCESDFQNFPKTIDYISLATYARLNLTKYIKNIEKAIYIDVDTLTNSSLQELWNIDITNYYLAACRDTFIDVKNEAYKKTIGLEGYSYFNAGILLINLNKWKEENIFQKSINWMNKYNNVMKYQDQDILNGICKGKVKFINNRFNFTPTDRDLIKKKNLLCVKMPIVISHYCGPNKFWHKKCSHLNCHIGNLLLKEMDKIIDIPSSWYDHFEKIPFLIKIKRLRKRIKDN
What are the official names of this protein?
Putative glycosyltransferase HI_0258.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
Protein: BEM2_ASHGO
Sequence: MPLKWAARNKKPPSAPQSCASKPSSASQSSCVDERISATPRSSISSNSSPNSKNNMSRHSHSNGSVYSDETTLKTAQTHYTQQGQQAKPQQHTQQQQQQPQTPMQLQVPTGQAHKRTLTCEDMKAGARCEEQVSPCSQPAGSPVRRGGGLNGETYDGTVFRLGWVNKAQGAAPAREGRYSHQPTASLSSIGSERPHFTGGGTSGYQYVATAYRLHRAQLKGCILNLYKSGLTNVKYFDPALEPSAAALQMHQERQEMPLLQPPLPSEAVPAPSILEASMESGELRLEYLSEAYPHPDLQLDKKDGKILSGSLESLCHAVLFMPTTDAKRVTDILLLLPLLDDFTRVLNYFNLFGKVFSKHHPAGAAGADDLNQNYNISNETDRQLTLRLATVVQTVLDMFPGFLLDDKIFQSLVILLDTISFHDEDTSQELKVAIAEKQTVLVKLTGFANEPIQSAKLDVLIKVQSFLKLDTEKVANQIHKINLTFNRVWSPQADYSLLYDSQYTQKHVELNPLVFFNDKNVQYLSRLMVSHIFCEETGFTPKKRAEVLTKWVQLGCKFERLGDMVSWLAIATVICSIPVLRLTRTWQYVPDSYLKIIFKDWVPTIVQLDRRQMSSKSMNSVFILAPPNLNDAFVRDNVIPYFGDLVIHSDDLPRDSKYKYLEKKIRRTKNAFYKWQQRLDQAFAQDRDSASSFTDSLHLDEEEHDVADFYQYWRFHMNLPPMNIETIMEMSLKMEPPSINQQTYSKTYSTRSALISGAYLPTLFTTLLPSYSLFPQELLIAAASTPSTKNNNSSQASNRISQLSVNSTPHSNASSSSAASAVTGIDNIDVPITKEISSKLSNKQVLLKFIRDMFNVDINVFHISDDVIFKSIRDYEAKSRPTSVVIESPKRLSLLSSVSPDVSAVSSALENLDLFKNFNSSSDDIAEFTVQVVLKCASLEKIFDILVLTSRVFSNLVTTTDLVSYFNSEKARREKSGAQHNGQHSIGLLDFALISLIMDNELFAETFFNNYKSFTTTLCVLENLAKRFIGAKSSAISISLINKLRNSESSRQIPPSTTSNQFSASGIFKPSYDELKFPVWDLKVTSVEGCPLDYLAKIQIGVLESLYHLIREHYADFTDDLANNKTFLDILKIINQEVYDEWDKRLDDLRNNNNSSQKRKNSCDDNSSAKITFHVNDARPENSNENKRGAATNLGDSSLAALEKLQCTLQDLYVKIKSSYQRQLYRPLGVTRNCRKVHDMLCQFQPQTSMSALIMNGSSDTLDKMVTEFQALKHTDYDDIINWIYKLDHFITSKLKLVSNQDWIQVSQILESLSNDSLVALFNYPLHAESNNVIASGSSQLDDLQILDIFTWLSTLESGSAHIIDKFPASVQLIVRLHLSLTKFFTVHIAHLHSTYEARVNTCSLILEILNFVHVKNANVNLFHSDDAGEGSMATISPHVPSFIETAIENAIISPESRFFEVSWKQAYKTISEKDEKLTFIGSVLTGLDKSTAHFLDADNRQPVRPKNFSPCPGWFISRLLEITGLVPNMSIENSKMINFDKRRFINNIVINYQDLIPNTEQLPSHDDEKSAHQFGSILFHYGTESSIKAFRKASKEAASNEARKLKFQAMGLFNDILVTEVYKVQRDQKKQEQLTVQEHEAKRSVLIQHPNKVSVSSASSSVSGSSSGSTARTSNPAHAAYALNMAGSLSISAARHGRSSVSSRSSVISNTATATSPASGASPNQTSTSHHGGMGKKIGGFLRRPFSISGFTSSSSQYTTTSVVLSGVQANGSISPYELPELTSEIQDTKIVTVIKTFEIKSCIQINNYRQDPDMMHCFKIVMEDGTQHTLQCMDDADMHEWMKAITLSKRYSFHSKRFKGKTSNKIFGVPVEDVCEREGALIPNIIVKLLDEIELRGLDEVGLYRVPGSVGSINALKNAFDDEGAVHNTFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKVDEFVNIMTAYKNHEVDLSQFQNGIKTLLSTLPVFNYHILKRLFLHLNRVHQHVENNRMDASNLAIVFSMSFINQDDLASTMGPTLGLLQMLLQHLIRNPEHYFT
What is the function of this protein?
GTPase-activating protein (GAP) for RHO proteins.  Required for polarized growth and maintenance of cell polarity.
What are the official names of this protein?
GTPase-activating protein BEM2.
Protein: FPOD_METMA
Sequence: MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYLQGITIVDRICYLVALTNEECYVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEYGEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFGGVRDDLPEGFKEKTIPVLNKLKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLVYRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVMRVPAGEVFHRVEDPRGEMGMYMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVSISGSMDGCTSEVDR
What is the function of this protein?
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system.  The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines.  Catalyzes the oxidation of methanophenazine to dihydromethanophenazine.  It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane).  It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
What are the official names of this protein?
F(420)H(2) dehydrogenase subunit D, F(420)H(2)-dependent phenazine dehydrogenase subunit D, F(420)H(2)-dependent phenazine oxidoreductase subunit D, FPO subunit D, Methanophenazine hydrogenase subunit D, Methanosarcina-phenazine hydrogenase subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MRAZ_COXBN
Sequence: MFRGLNPIAVDAKGRIAIPARYREPIESEADGILVVTIDTEERCLLIYTHPQWEQIEQKLENLPSYHPASRRIQRLLIGHATEVELDRSGRILIPPVLREYAGLGSMVMLVGQGKKFELWGKSQWETAREDWLAEELPKGDDLPPELRSLSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SUCC_SHEDO
Sequence: MNLHEYQAKSLFAEYGLPVSEGFACDTAQEAVEAAGHIGGDMWVVKCQVHAGGRGKAGGVKVTSSKDEIRAFAENWLGKNLVTYQTDAKGQPVAKILVESCTDIANELYLGAVVDRSTRRVVFMASTEGGVDIETVAEHTPELIHTAIIDPLTGPQAYQARDLGFKLGLNPTQMKQFTKIFMGLANMFNDHDFALLEINPLVITTEGNLHCLDGKIGIDGNALFRQPKIKAMHDPSQDDAREAHAAKFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDSNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGTNAELGREVLAKSGLDIIAATSLTDAAEQVVKAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: DXO1_KLULA
Sequence: MTTVSCDKDENKVDQLGESLSQLRISTRKNNKPSQKKGSLVLSCKKFPHVSVNYVVDKTPKLLTDCKEVHNCSYIINDATLLWNEASRKPRLRPEVCTYIKDSKWENKAVKDSFIGIDLTKGYDDYVPLDRNVLNSLVILKEAYQRYEKTLNPEKTTFVSLRHHIIDIIMCPFLDEPLSLLMTVQPDKNILISVDKSKDKPNGIHETRNSFNKKICYTGFALEDLLIESPTEGHILEHELYYSIVHGSLNDEIDLLIQAEMDSINTLTDTYTEIKSSVHFKLGNTYHRRKLLRMWIQTNLLPKSDLLIGFRNSYSNELEQLKAYKIQDIYHKINNSSIVGKPGKFYKFNPNVANDWFQHIFQVLKQNLLLLSQESTSTTFKVQIDTNLTLSISPASQFVTALG
What is the function of this protein?
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058).  The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (By similarity).  In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity).  Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (PubMed:22961381).  Has decapping and 5'-3' exonuclease activities (PubMed:22961381).  Has decapping activity toward incomplete 5'-end cap mRNAs such as unmethylated 5'-end-capped RNA to release GpppN and 5'-end monophosphate RNA (PubMed:22961381).  The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:22961381).
What are the official names of this protein?
Decapping and exoribonuclease protein 1, KlDxo1, 5'-3' exoribonuclease Dxo1, NAD-capped RNA hydrolase Dxo1, DeNADding enzyme Dxo1.
What is the protein family that this protein belongs to?
Belongs to the DXO/Dom3Z family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBE2F_CHICK
Sequence: MLTLASKLKRDDGVRGPRASNPASDSTRRVSVRDKLLVKEVAELEANLPCTCKVNFPDPNKLHYFQLTVIPDEGYYQGGKFQFEIEVPDAYNMVPPKVKCLTRIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVEDYIKRYAR
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins.  The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
What are the official names of this protein?
NEDD8-conjugating enzyme UBE2F, NEDD8 carrier protein UBE2F, NEDD8 protein ligase UBE2F, NEDD8-conjugating enzyme 2, RING-type E3 NEDD8 transferase UBE2F, Ubiquitin-conjugating enzyme E2 F.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.