PharMolix/UniProtQA huggingface dataset:
Protein: PREP_HUMAN
Sequence: MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ
What is the function of this protein?
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469).  Has an ATP-independent activity (PubMed:16849325).  Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155).  Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469).  Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155).  Also degrades other unstructured peptides (PubMed:19196155).  It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469, PubMed:26697887).  It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469, PubMed:29764912, PubMed:29383861).  Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469).  It is also able to degrade amyloid-beta protein 42 (PubMed:29764912).
What are the official names of this protein?
Presequence protease, mitochondrial, hPreP, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix.
Protein: PUR5_BRUO2
Sequence: MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKDPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKPLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRP_SCYCA
Sequence: APVENQGSFPKMFPRGSHWAVGHLM
What is the function of this protein?
Stimulates the release of gastrin and other gastrointestinal hormones.
What are the official names of this protein?
Gastrin-releasing peptide, GRP.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
Protein: Y2879_DECAR
Sequence: MQIWVDADACPGVIKEIIYRAAERRQIQTTLVANQMLRTPPSKYIRAIQVAHGFDVADAHIVDQVVAGDLVVTADIPLASLVIERGAHALNPRGEMYTTANIRERLTMRNFMEDLRSAGVQTGGPNAFSQADRQAFANQLDRFLAKIPVA
What are the official names of this protein?
UPF0178 protein Daro_2879.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: INA_BACTL
Sequence: MKDAKADTKEKLNQPATGTPAATGPVKGGLNGKVPTSPAKQKAYNGDVRKDKVLVLLVEYADFKHNNIDKEPGYMYSEDFNKEHYEKMLYGDEPFALEDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPGKAADYGADAATGHDNKGPKGPRDLVKDALKAAVDSGLDLSQFDQFDQYDVNGDGNQNQPDGLIDHLMIIHAGVGQEAGGGKLGDDAIWSHRWTVGPKPFAIEGTQAKVPYWGGKMAAFDYTIEPEDGAVGVNAHEYGHDLGLPDEYDTDYTGHGEPIQAWSVMSGGTWAGKIAGTTPTSFSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSNRPGMIRVNLPDKDVKTIRPAFGKQYYYSTKGDNLHTTLETPLFDLTNATNAKFDFKSLYEIEAEYDFLEVHAVTEDGQKTLIERLGEKANSGNAEATNGKWIDKSYDLSQFKGKKVKLTFEYITDGGLALNGGLLDNASLTVDGKVTFSDDAEGTPQLKLDGFVVSSGTEKKKHNYYVEWRNHTGSDSALKFARGPEYNSGMVVWYADSAYADNWVGLHPGHGFLGVVDSHPEAIVGTLNGKPTIDSSTRFQIADAAFSFDKTPAWKVVSPTRGTYTYDGLAGVAKFDDSKTYINQQIPDAGRILPKLGLKFEVVGQADDNSAGAVRLYR
What is the function of this protein?
Neutral metalloprotease that is secreted to degrade antibacterial proteins produced by the insect host for its defense (attacins and cecropins).  Probably degrades some unknown crucial protein(s) too, since it is toxic when injected to insect larvae.
What are the official names of this protein?
Immune inhibitor A.
What is the protein family that this protein belongs to?
Belongs to the peptidase M6 family.
What are the subcellular locations of this protein?
Secreted.
Protein: BPP_BRAEP
Sequence: WPPPKVSP
What is the function of this protein?
The amidated peptide increases the release of nitric oxid (NO) and that NO mediates the endothelium-dependent vasodilatation.  In addition, it inhibits efficiently angiotensin I-converting enzyme (ACE) in rat serum (IC(50)=8. 2 uM).  3D-structure modeling of this peptide in complex with ACE suggests it acts by inhibiting the ACE C-terminal catalytic site.
What are the official names of this protein?
Bradykinin-potentiating peptide Brachy, BPP-Brachy, BPP-BrachyNH2, Proline-rich oligopeptide, PRO, Proline-rich peptide.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS5_HAEI8
Sequence: MSNIEKQVGELQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALNEGTLQHPVKGVHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVRNVLSKAYGSTNPINVVRATIDALANMKSPEMVAAKRGKTVDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RPOA_HERAR
Sequence: MQNSLLKPRIIEVEVLGAGHAKVVMEPFERGYGHTLGNALRRVLLSSMVGYAPTEVTIAGVVHEYSSLDGVQEDVVDLLLNLKGVVFKLHNRDDVTLTLKKEGEGAVLASDIELPHDVELVNPDHVIAHLTAGGKLDMQIKVEKGRGYVPGNVRRLSEDTNKTIGRIILDASFSPVRRVSYAVESARVEQRTDLDKLVINIETNGVITPEEAIRQSARVLVDQLNVFAALEGTEAPADAPSRAPAVDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRSENELLKTPNLGRKSLNEIKEVLASRGLTLGMKLENWPPAGLEK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: NUOB_MYCUA
Sequence: MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVNRERAIAEAEEAAMLARPTIEMRGLLR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LGT_COXB1
Sequence: MLYYPHIDPVAFRLGPLKVHWYGLMYLVGFAMAWGLALYRARDPKRHWTAQQVGDLIFYGALGLIIGGRLGYMLFYDFSNFIANPLTLFQVWRGGMSFHGGLIGVIVTTWIFSRRTHKRWMDVTDFVVPLVPLGLAAGRIGNFINGELWGRVTTVPWGMVFPNAGPLPRHPSQLYEFLLEGVLLFIVIWWFSAKLRPRFAVSSLFLLCYGLFRFTAEFFRQPDPQLGFVAFGWLTRGQELSLPMIIIGGFALWWAYRHKER
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNA_GLOVI
Sequence: MTFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGVAAAFGMVLGWQEAPQGDPITHLERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLEREATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNAGALATAGYGTALGVVRSAHRADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRIAANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEGVALCPQGVEFYNPAFDVTPASLVTGIIVESGVYAPGELAAAGQVRLGR
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: RL10_NITEU
Sequence: MSHNLEGKKAIVAEVSSQVAKAQAIVIAEYRGLGVDQFTRLRVKARESGIYFRVIKNTFARRAVADTPFSGLAESMVGPLAYGIGSDPVATAKILHEFAKDNDRFVIKAGAMAGIVMSDKDVAALAVLPSREELLSKLLGTMQAPIAKFVRTLNEVPSKFVRGLAAVRDKK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: IAA13_ARATH
Sequence: MITELEMGKGESELELGLGLSLGGGTAAKIGKSGGGGAWGERGRLLTAKDFPSVGSKRAADSASHAGSSPPRSSSQVVGWPPIGSHRMNSLVNNQATKSAREEEEAGKKKVKDDEPKDVTKKVNGKVQVGFIKVNMDGVAIGRKVDLNAHSSYENLAQTLEDMFFRTNPGTVGLTSQFTKPLRLLDGSSEFVLTYEDKEGDWMLVGDVPWRMFINSVKRLRVMKTSEANGLAARNQEPNERQRKQPV
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin-responsive protein IAA13, Indoleacetic acid-induced protein 13.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LOLB_PSEPG
Sequence: MFLRHCITFTLIALLAGCAGFGSREALQGHGDPQQWRAHKEQLSSLDGWQINGKVGIRAPRDSGSGTLFWLQRQDYYDIRLAGPLGRGAARLTGRPGGVVLEVANQGRYEATSPEALLEEQLGWQLPVSHLVWWVRGLPAPDSKSKLTLDGDSRLASLDQDGWQVQYLSYTEQNGYWLPERLKLHGKDLDVTLVVKDWQPRQLGH
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CPS1_ISORU
Sequence: MASLSTMHLINHSPASRRRIMSAAAAAAAKLHLPECFTITKSAWMNNTENLTLNYQLNHKKISKVAGINRVATVDAPQVHDQDDSTENQGHDAVNNIEDPIEYIRTLLRTTGDGRISVSPYDTAWVALIKDLNGRDAPEFPSSLEWIVRNQLDDGSWGDDKFFCVYDRLVNTIACVVALRSWNVHDDKLKRGVTYIKENVEKLRDGNVEHMTCGFEVVFTALLQRAKCLGIEDLPYDSPLIQEIYHSRQQKLNRIPMEMMHKVPTSLLFSLEGLENLEWERLLKLQSADGSFLTSPSSTAFAFMQTKDEKCYQFIKNTVETFNGGAPHTYPVDVFGRLWAVDRLQRLGISRFFESEIAECLAHIHKFWTEKGVFSGRESEFCDIDDTSMGIRLLRMHGYDVDPNVLRNFKKDDNFSCYGGQMIESPSPIYNLYRASQLRFPGEEILEDANKFAYNFLQEKLANNQILDKWVISKHLPDEIKLGMEMPWYATLPRVEARYYLQYYAGSGDVWIGKTLYRMPEISNDTYHELAKTDFKRCQAQHQFEWIYMQEWYESCNVEEFGISRKELLLAYFLATASIFELEKTKERIAWAKSQIISKMITSFFNNHNTSSEEKLAFLTDFRNSNGLNNTNMVLATLTQFLEGFNRYTSHQLKNAWGEWLAKLQQGEGDGAADAELLTNTLNICAGHIAFREEILSHNEYTTLSNLTSKICQQLSQIQNEKKMEIEGQMTAETSIKNKELEQDMQTLVKLVLGKSSGINRNIKKTFLAVAKTYYYRAYHDAQTIDTHMFKVLFEPVV
What is the function of this protein?
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities (PubMed:28381502).  Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to (+)-copalyl diphosphate ((+)-CPP) (PubMed:28381502).
What are the official names of this protein?
Copalyl diphosphate synthase 1, chloroplastic, IrCPS1, Terpene synthase 3, IrTPS3.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsc subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TXA02_LYCSI
Sequence: MKLIIFTGLVLFAIVSLIEAEEESGRVCIPLNGECSKSPDKCCDNINCDCYLRFEKGVQTGRPCFCTEKDVIFERDE
What are the official names of this protein?
U10-lycotoxin-Ls1a, Toxin-like structure LSTX-J2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 09 (U10-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IOVO_AEPAR
Sequence: VVIVDCSDYPTHGCTLELKPICGSDNQTYSNKCGFCNAVAQSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: CCR4_USTMA
Sequence: MSSPGGLHSAHLSSSASRSEAVANAANAAAAAAAAASGSPHWQQQIVKAEISRQSNSPHHHARAAALAARSATSSAIAIQDPSKGIVTPQVAANGLFVAKKDSSAANGGGADDGKGSGADTAPATTNGAAPISSTSAKDKQTWSTIDMGGLALKNIANEVYRYSFLTSLFINHNALTTLSSDIVKLRHLTVLDASGNKLSSVPPELGMLTSLRELFLFDNNLATLPPELGTLHQLEMLGVEGNPLQDNLRSLLQREGTTAVIAYLRDSCPVPLPPPEREWIMIDPDLPDLDADKHANDATQESFNVLSYNILFDRYATAQMYGYTPSWALAWDYRKEFILQEVMSYSADICCLQEVGVEQYEDYFLHHLSQQDYEGVFYPKSRARTMRDDERRRVDGCAIFYKSNKYQLIEKQLVEFNQIALQRPDFKKSEDMYNRVMTKDNIAVIALLENKLSGSRIVVANVHTHWDPAFRDVKLVQVAMLMDEVEKAGARFAKLPPKPSVAEGYPPPPKYTHANQIPTIICGDFNSVPETGVYDFLANGAVPGDHEDFMDHVYGNYTAQGLQHSYKLESSYVPIGELPFTNYTPGYEGAIDYIFYTKNTLSVTGVLGEIDKQYLSKVVGFPNAHFPSDHICIMSEFNVKRSDRGSSSTTAREVHHPTSSSNASSMPRR
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PTH_METMP
Sequence: MYEQAIVIRNDLKMGKGKMAAQACHASIQAFLHAQKISSSAVSGWMNEGQKKVVLKVNSEKELLEIFKNVNIEGLPCSLIRDAGRTQIEPGSLTAVGIGPEKEEKISKVKKDLKLL
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_NAUPA
Sequence: MAVLDIVTYPNKVLKQISKPVERFDKDLHKLLDDMYETMIKNNGVGLAAIQVAVPIRALLIDIGDEEGKQSKDTLIEVINPEFLTWDGTQKDTEGCLSVPDYFDEVERYKNVKVKFFDRFGKEHVMEAEGLLSVAFQHETDHLDGHLFVERLDYIKRKKFEKEWKKLLKQKRKK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: GRP4_RAT
Sequence: MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLLTSYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV
What is the function of this protein?
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP.  May function in mast cells differentiation.
What are the official names of this protein?
RAS guanyl-releasing protein 4.
What is the protein family that this protein belongs to?
Belongs to the RASGRP family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.
Protein: KAR5_CANAL
Sequence: MNIVLLIYCLAMVVAHDLQLFGDFKFELSDNWRNDCAKKALEPIINQCAEGIETISPFQQKSIAIQLSICEFENAEISYPSECRSQNLDTCILLLEKSPQYWTTFSGYYREIRNICHQVSLPFAKDQILQVYGNITEFYRTLMDEMTNSSKYTENMQNELKAKFDKLIGVIDLILADREKNREDLKSSFNMFKNNFEKSLNNALVVMKHSYEDANSNVKELESHLNYFINDMSQVYILINEKALEVKSQQDRIKEHNADILNQIEEIKKNLDNAYEEASEVQISNNQLVHDIQSSLDYSLFTVSNLNSHLQLSINDFIEKNEDIRSRAPIIFEEIFGLFLNHLNESGQLAMDSFEAALDLSLNMLHQKLNQTERSIDNLNSKVSDLAHFADSLKKYASSIFNVPNYVRTSMNHKIQQWREFGNIMVVGGVFFFVVLTLLVLSFIRTQVMKVFRFAFIGIPMITGIALAIFILRLLSMPMKVVDID
What is the function of this protein?
Required for nuclear membrane fusion during karyogamy.
What are the official names of this protein?
Nuclear fusion protein KAR5, Karyogamy protein 5.
What is the protein family that this protein belongs to?
Belongs to the KAR5 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Protein: RL17_PELUB
Sequence: MRHGMANKKLNRTSEHRKALLKNMLNSLIKYEQITTTLPKAKFLKPQADKIITLGKKETLQTTKMLMSKLQDITSANKVKKTLSKRYEARNGGYTRIIKAGFRYGDNAPMAVIEFVDRDVEAKRVDRKKKDPAKDKTEEKKLATA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: LA1_LIOAU
Sequence: FGESCIAGRFIVPLGQQVTDQRDCALYKCVNYNKKFALETKRCATVNLKSGCKTVPGGAGAAFPSCCPMVTCK
What is the function of this protein?
Not toxic to insect.
What are the official names of this protein?
Venom peptide La1.
What is the protein family that this protein belongs to?
Belongs to the scorpion La1-like peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: YD008_YEAST
Sequence: MFRSFMLAFQKACRQVHKQYLNKYYSVITYFLAFLTKFAILLESFTPFVSTPPLTSTPITPFNLSASPTFSGVSPPANIKCKLSGLSCLPTQSEIEFQSKSSPVPPASESNKGINE
What are the official names of this protein?
Putative uncharacterized protein YDR008C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TVP38_YEAST
Sequence: MSQSYEAGNANMGQGEDDEFDGYFEDFDNDIMPNSNNGQRVGTNAGLSFNDEVNVNDDDFLDIYNMSPRERLMHNIRKNVQKLQFYFYSLRLWQQIIIVLLGIMLMIMGILLLVFHNAILHKVVVTSNDLREKMSTHFILMVLIFFVAFPPMIGYSLLSTTTGLIYGVSFEGWVTLALGSVTGSIASFVVFKTILHSRAEKLVHLNRRFEALASILQENNSYWILALLRLCPFPYSLTNGAIAGVYGISVRNFSIANIITTPKLFIYLFIGSRVKSLAESESTGSRVFDLVSIIITLLILSLTAWLLYFKTKKRYLELQNRDRQVSTDQLPELSFEV
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking and spindle migration.
What are the official names of this protein?
Golgi apparatus membrane protein TVP38, TLG2-vesicle protein of 38 kDa.
What is the protein family that this protein belongs to?
Belongs to the TVP38/TMEM64 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: CYTR_ECOL6
Sequence: MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALRRCGIMVDPQYIARGDFTFEAGSKAMQQLLDLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
What is the function of this protein?
This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins.  Binds cytidine and adenosine as effectors (By similarity).
What are the official names of this protein?
HTH-type transcriptional repressor CytR.
Protein: RS13_HAEIN
Sequence: MARIAGINIPDHKHAVIALTAIYGIGKTRSQAICAAAGIAEDVKIRELSEEQIDKLRDEVGKFTVEGDLRREVTLNIKRLLDLGCYRGLRHRRSLPVRGQRTKTNARTRKVHVSRSKNSRGK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PO5F1_MACMU
Sequence: MAGHLASDFAFSPPPGGGGDGPGGPETGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGAGVESNSDGASPEPCTVPTGAVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGSLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVPVTTLGSPMHSN
What is the function of this protein?
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').  Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).  Critical for early embryogenesis and for embryonic stem cell pluripotency.
What are the official names of this protein?
POU domain, class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus.
Protein: YEEX_SALSV
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDIEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKSDYEDRVDDYIIKNAEISKERRDISKKLKAMGEMKHADVKAE
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.