PharMolix/UniProtQA huggingface dataset:
Protein: ACTP_YERPA
Sequence: MKIRHWSALSLFVLPALAQAEALTGEVHRQPLNIQAIVMFLLFVGGTLYITYWASKRTRSRQDYYTAGGRITGFQNGLAIAGDYMSAASFLGISALVYASGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQRPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVMLLSGATFMAIMVMKSVNFNFNTLFSEAVKVHPKGLSIMSPGGLVSDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVGPNQTFKDAAGALLGGNNMAAVHLANAVGGSFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVIKKGKANERDELRVSKITVIILGIVAIGLGILFENQNIAFMVGLAFSIAASCNFPIIIISMYWDKLTTRGAMIGGWLGLSTAVILMILGPTIWVTILGHEKPIYPYEYPALFSMIAAFVGTWFFSITDNSETGKQERLLFKSQFVRSQTGLGASKGGAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX2_ACHDO
Sequence: MATWSNLNLQNSSSPLMEQLIFFHDHTLMILLMITVLVAYIMSMLFFNLYTNRFLLEGQTIEIIWTILPAITLIFIALPSLRLLYLLDESMDPLITMKTIGHQWYWSYEYMDFKNIIEFDSYMSALDKLSSFRLLDVDNRTILPMNTQIRTLVTAADVIHSWTVSALGVKTDATPGRLNQINFMINRPGLFYGQCSEICGANHSFMPIVIESVNLKNFINWIKNYSS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PREU8_PREIS
Sequence: MNVLVLGDQVADHLQLLENTYHRKNNASVKGFLDRATDVLLSEIAKLPKRQRENIPEFRTILNLVQLYRERGLAIPHVESALVTVSQLAYYIGYFADYPTDLPNPENKRVLGLCTGQLAASVVASSHTLDELLPIALEAVKLAFRTGLEVACQGEAIEQGPLSSEKWSTVVQDITEDEAMSLIDNFHKERKIPVSAHAYISAVAPTSITVSGPPSTTKELFEIEELSKKRKTPIPVFAPYHASHLYDASVIDRIIGDSAEVLKRYRSRALFHSASTGKCHITTDTLELVRVALREILLEPVRWSSLIEECVSQVLESGDTECTVFPIGATMVTNSLVSTLKAAGQSSLSVRVSKPWGPDWEGTKGRTQNDKIAIVGMSGRFPSAASHEELWELLAKGLDVHREIPSDRFDAQAHCDPSGKGKNKSHTPYGCFIDEPGMFDPRFFNMSPREAAQTDPMGRLALTTAYEALEMSGYVPNRTPSSMLNRIGTFYGQTSDDWREINAAENVDTYFITGGVRAFAPGRINYYFKFSGPSFSIDTACSSSLAAIQLACTSLWAGDCDTACAGGLNVLTNPDIFSGLSKGQFLSKTGGCKTYDNDADGYCRGDGCGTVILKRYEDAIADKDNILGCILGAATNHSAEAVSITHPHAGAQEFLYKKVLANAGVDAHEITYVEMHGTGTQAGDGIEMTSVTNAFAPRNRQRRPDQPLYLGAIKANIGHGEAASGINSLVKCMMMLKKNAIPANVGIKGVMNKTFPKDLAQRNVHIETEMVPYPRKGAEKRKMFLNNFSAAGGNTAIILEDGPLREAPKGVDPRTSQVVTITGRSISSLKKNIDNLIKYLDQNPDTTLPSLAYTTTARRIQHNYRVAVVVSDISQVKDALKNQIKDSYSPVAMVSTKTAFTFTGQGSQYTGLGKKLYEEMGSFKSDIHQLDNLARLHSLPSIIPLLDGSTDVAKLSPVVVQLGMACIQVALSRMWASWGVTPSAVIGHSLGEYAALHVAGVISASDMVLLVGRRAQLLEKECTAHTHGMLAVKGGVESISDALGDKMIEIACMNGPEETVLCGKVDVIESTADALATKGFKATKLNVPFAFHSAQVEPILEKFQDVATSVKFKKPVVPVLSPLNGEVIREAGIIGPKYLADHARRTVDFWHALSAGKDEKAFDEKTAWLEIGAHPVCSGMVKSSLGGSPCTAGSLRRNEDPWKTLANSVSTLFLAGVGIDFPEYHRQFDDAHELLTLPTYAFDNKKYWLDYHNNWTLTKGEARTDAAPKTIEAPAEVKSKLSTTSCQRIVREELHANSGTVVVQSDLSDPKLRATISGHQVNGTPLCPSSLYADQAMTLADYLYKQLRPNLPTPGLNVCAMEVPKTLIPQYPPPAGGQHLQIEATADLEHNRVEVRFRTVPADGSKILAEHAFGTVKYEDVSQWKEEWARTQYMVQTQIDLLKQKLVSGSAHKVLRGMAYKLFKALVSYADNYRGMEEVILDGKQTEATATVKFQTTPEDGSFFCSPYWIDSLAHLSGFIVNASDHLDSENSVYISHGWGSIKISKQLSPEKRYQSYVRMQPAPGNISVGDVYILEGEEVIGLVTGLKFQNIARRVLNIMMPPAGGAAKAAGGKAAPAKKAASPTLAPAKAAKPAAKTSKPSKARAKPAADSTTSRVMKIIATETDVDMAELVDEAAFENLGVDSLMSLTISAKFREELDLEISSTLFTDHPTVGQMKKFFSQYDGAPIPDDGDDSDGTDEPSNFSTPSYGADNASTPPSSAPSVNGKSSPENHEVLESTEVSLARKIVAEEMGVDVAEITDKADLSEMGMDSLMSLTILGALRESTGIDLPSTFLVTNVTIEDIENELGMRPKPKPKAEAAPPKSSAKASPSANKQPQLSAVNEKLKNIVDVSQYPPANSVLLQGNPKIATKKMFLVPDGSGSATSYISVPPISPDLAVFGLNCPFMKSPEKWTCGVEGVSALYLAEIKRRQPKGPYIIGGWSAGGVMAYEVTQQLVNSGEVVERLVLIDAPCPVALDPLPARLHIFFDQIGLLGTGKPGGTPKWLLPHFASAIQNLKDYEPIPMDPQRAPEVFAIWCTDGVCPNPDDPRPPPGEGEDPAPMKWLLNNRTDFEDNGWAQLLPKKNFTYAVMGGNHFTMMKGDHGAKLGEHLKEGLKL
What is the function of this protein?
Non-reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified natural product.
What are the official names of this protein?
Non-reducing polyketide synthase Preu8, NR-PKS Preu8.
Protein: NQOR_SINFN
Sequence: MAKVLVLYYSAYGHIEKMAYAVAEGAESAGAEVSVKRVPELVSEEVAKASHYKIDQPAPVATVEELGDYDAIIFGAGTRYGTVASQLRNFIDQTGSLWAKGKLVGKVGSAFTSSATQHGGQESTILGLIPTMLHHGMVVVGLPYAFQGQMGIDEIKGGSPYGASTITGGDGSRQPSEIELDAARFQGAHVARIAAKLAD
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: DPS2_BACAN
Sequence: MNKQVIEVLNKQVADWSVLFTKLHNFHWYVKGPQFFTLHEKFEELYTESATHIDEIAERILAIGGKPVATMKEYLEISSIQEAAYGETAEGMVEAIMKDYEMMLVELKKGMEIAQNSDDEMTSDLLLGIYTELEKHAWMLRAFLNQ
What is the function of this protein?
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).  It is capable of binding and sequestering Fe(2+) ion.  Does not bind DNA.
What are the official names of this protein?
DNA protection during starvation protein 2.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIS1_ASPFU
Sequence: MSQLLTARQAEELHKSIIAYLASVNLTESSAALRAELGDSVSIDDATLKKYEGLLEKKWTSVVRLQKKIMDLESRCAALQSELDSATPTSLLRKNQDPTSWLPRSPARHILEGHRNPVTCVAFHPVFSSLASGSDDTTIKIWDWELGELERTVKGHTKAVLDVDYGGPRGGTLLASCSSDLTIKLWDPSDNYKNIRTLPGHDHSVSSVRFIPSGAAGSPMSGNLLVSASRDKTLRIWDVTTGYCVKTLSGHVDWVRAVAPSIDGRFLLAAGDDRIPRLWDLSSAETKSTFLGHEHVIECVAIAPAASYPHLAVLSGLKKPPPASSSAEFFATGSRDKTIRLWDSRGNLIKTLVGHDNWVRALAFHPGGKHLLSVADDKTIRCWDLTQECKCVRVISDAHGHFVTCLRWAPPLIKDGGANGEAETNGTPAATSTTNGVRPDPNVATKISIRCVIATGSVDQKVRIFAT
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein nudF, Lissencephaly-1 homolog, LIS-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: NDK_BURP0
Sequence: MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGEDAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCKR_XENLA
Sequence: MRGTRKYQHVIETPDPGKWELAGYEESLPISEKSNPMTRELDKADPSQLVQLLRDCDAEIFQEEDENLIHYHRLYSESVLKTMGDVAKRVQEVLKNPDDSLVVLSGCGTSGRLALLLANSFNGLLKGLHKTPCYCYIMSGGDRSIVTSQESSEDNPQLGAQELEKVCEGKKNVLFIGISCGLSAPFIAGQLDFCMRHLDVYLPVLVGFNPVSMARNERIEGWHSSFRQVAERLQTLHDSQKGFILNPAVGPEGVSGSSRMKGGSATKILLETLLLVAHKAESNVPVTEKCLLEILRTYERAHKVTYSQSKKIAALMKQTATSLQKKGHLYILGWGTLGLVGIMDAVECVPTYQADWRDVRGFITGGYHSIENKEGDLSSLGPQFSISHEDFVKNVLPSVSETDTVLLIFTLDDDLNQIEKLVALVKEKTSNIQVICHATAGQYLPNSLKKTIPSIIGLTWPILFLEYEGAFIQKFQRELSTKWILDTVTSGAYTLRGKIFRNFMVDFKINNSKLFHRATSVLQRLTGQSHQRCTEVLLQSIYGEQTLSEQIRNTTIAGHVEAAASQDKVLPVAIVSLLRSCTIQDSRSRINSSLSIRSAIESSMNVPGRKRGAEDSESR
What is the function of this protein?
Regulates glucokinase (gck) by forming an inactive complex with this enzyme (PubMed:23733961).  The affinity of gckr for gck is modulated by fructose metabolites: gckr with bound fructose 6-phosphate has increased affinity for gck, while gckr with bound fructose 1-phosphate has strongly decreased affinity for gck and does not inhibit gck activity (PubMed:23733961).
What are the official names of this protein?
Glucokinase regulatory protein, GKRP, Glucokinase regulator.
What is the protein family that this protein belongs to?
Belongs to the GCKR family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion.
Protein: YCXE_CYAPA
Sequence: MLYLRDHQPVAVLFDDNFEKIQGVVDRNGYVFKNVTPQQITTIEFLLNKKLLKVRGFKNIIIRWAALYLLICDSQTKIYEVILEKGHDITFGTEAGYVFFGEYINMDQLRKRFFYMDHLHNLWREGNLFSEVHVNLTKSAHCYIDLTENKTPILSMLDDVSSFRIKDDNYRWPSQLKDE
What are the official names of this protein?
Uncharacterized 21.2 kDa protein in ycf23-apcF intergenic region, ORF179.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: LBD32_ARATH
Sequence: MASNRCAVCKILNETCAPMCIYAPHFPSNDASFKVIIQIFGAVNVCNILDNLEFPEQREIAANCLRYAAEARIRNPISGCHDMILQYKNILNNVEQDIESAVNELGTYVGHDQVPKFYDLPMPDDFLMTPVSLDSFIAKIKSLNEVQKNQLMQLPTAADNAPMIMNSIFGKMEDKNLKDGHRADGASTSAGK
What are the official names of this protein?
LOB domain-containing protein 32, ASYMMETRIC LEAVES 2-like protein 26, AS2-like protein 26.
What is the protein family that this protein belongs to?
Belongs to the LOB domain-containing protein family.
Protein: RPOY_GEOKA
Sequence: MIFKVFYQENADEAPVREKTKTLYIEAESERDVRRKLEGRPINIEYIQPLEGAHLEYEKKSPNFQVLEISS
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: GMHA_DESDA
Sequence: MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADAQHLAAEFVNRFLVDRPALPALALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGISTSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHMLVDVANPSTPLIQEIHITAGHLLCQLTDYYLFENVAALAPYLHADTVNED
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLP2_EPIUN
Sequence: MDLTQFNTAGIVWLTVAAIAISYILQSSFLSWYRLRHIPGPFLASISSLWNVLNIVTGRTSPVLEKLPGRYGPLVRTGPNYVLTDDAEILRHVNGVRSTYPRNGWYEGFRVDEYDHMGSHIDTSVHDAIKSKVIGGYNGKDGIDLEGAIGSQVKTLVSEIRRTRGSRPRSRPRWMPARWSRSSP
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of loline alkaloids, potent insecticidal agents composed of a pyrrolizidine ring system and an uncommon ether bridge linking carbons 2 and 7 (PubMed:15654104).  Lolines are structurally differentiated by the various modifications of the L-amino group and include norloline, loline, N-methylloline, N-acetylloline, N-acetylnorloline, and N-formylloline (PubMed:15861432, PubMed:25531527).  The first committed step is the condensation of O-acetyl-L-homoserine (derived from L-aspartic acid) and L-proline, probably catalyzed by the gamma-type pyridoxal 5'-phosphate(PLP)-dependent enzyme lolC, to give the diamino diacid, NACPP (PubMed:15861432, PubMed:16755627).  Ensuing cyclization, decarboxylation, and acetylation steps yield 1-exo-acetamidopyrrolizidine (AcAP)(PubMed:24374065).  LolO is required for installation of the ether bridge upon the pathway intermediate, 1-exo-acetamidopyrrolizidine (AcAP) (PubMed:29537853).  In sequential 2-oxoglutarate- and O(2)-consuming steps, lolO removes hydrogens from C2 and C7 of AcAP to form both carbon-oxygen bonds in N-acetylnorloline (NANL), the precursor to all other lolines (PubMed:24374065, PubMed:29537853).  The enzymes lolD, lolE, lolF and lolT have also been proposed to be involved in the ether-bridge installation (PubMed:15654104).  Further processing of the exocyclic moiety of NANL by fungal N-acetamidase (LolN), methyltransferase (LolM), and cytochrome P450 (LolP) enzymes, with occasional involvement of a plant acetyltransferase, generates the other known lolines (PubMed:25531527, PubMed:18655839).  LolN transforms NANL to norlonine which is monomethylated and dimethylated to respectively lonine and N-methyllonine (NML) by lolM (PubMed:25531527).  LolP catalyzes hydroxylation of the methyl group in N-methylloline (NML) and further oxygenation to N-formylloline (NFL) (PubMed:18655839).  A plant acetyltransferase is responsible for the acetylation of loline to form N-acetylloline (NAL) (PubMed:25531527).  LolA might interact with aspartate kinase to prevent feedback inhibition of its activity by these end products and thereby promote production of L-homoserine from L-aspartate (PubMed:15654104).
What are the official names of this protein?
Inactive cytochrome P450 monooxygenase lolP2, Loline biosynthesis cluster 2 protein P.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NUON_GEOKA
Sequence: MNDVWQSDWSMMAPEWIVLAAAIALLVMDLALPSDRSRRPLAWGAAAAAALAMIATAAMIPAGSASILHDTFRLDAFAKAFKFILLAGGALALLLVAEWAPKEGSPHRGEFVYMMLFALLGAMMMASSGDLLTLFVSLELLSVSSYILAGLRKTAPASNEAALKYVINGGIATAIMLFGMSYVFGLTGTTNLGGIARRLQETNEPYMLALAFLLLLIGVSFKLATVPFHMWAPDVYEGAPVPATAFFAVVSKTAGFALLLRLLVTIFAAAPSEGRDPSSLLLSMQPIITVLAGLTMIIGSVVALRQRSLKRLLAYSGIAHAGYLLAGFAAMSWAMIDSLWMYLLVYTLMNIGAFAIIAHIVNETGSDDLDGLAGLYRHRPFLAAALGLFLLSLAGIPGTAGFIAKLHIFIGLVVTEPGHYVLAAVMAITTVISYVYYFNLIVQLFFRPTFTAPLGRLPAGLSTAVVLCALGTLAIGWAPGLAYDMLAQFGHFGDFLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TILS_RALSO
Sequence: MLLVDKVAQRVVACAAFVVSGGVPTVAVALSGGRDSAALLHAVAAWRDAAGVPVRLVALHIHHGLQADADAWEAACARMAAAVGAAFRVRRVRVSTDAGRGIEEAAREARYAALDALCAETGATLLLTAHHLDDQAETVLLQLLRGAGLDGLSAMPMARERRVTLLRPWLDVPRGDIEAYARAHALAWVEDPSNGDARYARNALRPLLAGMAGHFPAYRASLARSAAHLAEAAALIEEVAQTDLARIAPAGTLAVAGLAALSGPRQRAALRAWLAGAGLRAVSSRRLEDLRAQLLGARADGAPCVRLPGAQVRRYRGQAWIEAAGQPGAGPADCPIAVSRFDPARAEVQRVDVAAWGGALLFSPAQAEGIDARILQAPLSLAARRGGERIVLRPGGPSRALKQAYQEAGIPAWARARLPLLYAGERLVFAAGLGPDRSAVAMGSGWHVAWLPAVGQDGLDAG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_ROSS1
Sequence: MPIRDQIIQIVRGHDLSEDQAAEAMEEIMTGMATPAQVAALLTALHLKGETDAEIAGMARVMRAKAIPVHFDAPLLDTCGTGGDGAGTFNISTTAAFIAAGAGAIVAKHGNRAMSSVCGSADVLEGLGVNIELDAASVARCLDQAGIGFMFAQKFHPAMRFVGPVRREIGIRTVFNILGPLSNPAHARHQVLGVADPALAEKMARALHLLGTQHALVIHGHGGLDELTLSGPNLVIDVRAGHTPRRYEVTAADLGLAPAPREALRGGDVSVNVAIVRGILSGEDQSARRDVALLNAAAALVAADRAADLRDGLHQARHSLESGAALARLERLITVSRGGEG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: IHFA_SHESR
Sequence: MALTKAEMAEHLFETLGINKRVAKEMVESFFEEIRGALESGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPISARRVVTFRPGQKLKTRVEASNAGK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: Y539_MYCTO
Sequence: MAGDAVTVVLPCLNEEESLPAVLAAIPAGYRALVVDNNSTDDTATVAARHGAQVVVEPRPGYGSAVHAGVLAATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRRRPVAGLHWPWVARVGTVVMSWRLRTRHRLPVHDIAPMRVARREALLDLGVVDRRSGYPLELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKVIS
What are the official names of this protein?
Uncharacterized glycosyltransferase MT0564.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: DCEA_ECO57
Sequence: MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKEGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
What is the function of this protein?
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction.  The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions.  The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity).
What are the official names of this protein?
Glutamate decarboxylase alpha, GAD-alpha.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: HIS9_LACLA
Sequence: MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQEINRLQAEFKDKIKIKIGLEMGIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEFYLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYGPYTDKSIKFAENREILFEILRALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKARTLIKKAGFHELATFSGMKIDKNKKSIKE
What are the official names of this protein?
Histidinol-phosphatase, HolPase.
What is the protein family that this protein belongs to?
Belongs to the PHP hydrolase family. HisK subfamily.
Protein: HIS1_SHIBS
Sequence: MTDNSRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADM2_HUMAN
Sequence: MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
What is the function of this protein?
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation.  Important for synapse organization, providing regulated trans-synaptic adhesion.  Preferentially binds to oligodendrocytes.
What are the official names of this protein?
Cell adhesion molecule 2, Immunoglobulin superfamily member 4D, IgSF4D, Nectin-like protein 3, NECL-3, Synaptic cell adhesion molecule 2, SynCAM 2.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
Protein: PRPH2_MOUSE
Sequence: MALLKVKFDQKKRVKLAQGLWLMNWLSVLAGIVLFSLGLFLKIELRKRSEVMNNSESHFVPNSLIGVGVLSCVFNSLAGKICYDALDPAKYAKWKPWLKPYLAVCIFFNVILFLVALCCFLLRGSLESTLAYGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQLTNNSAHYSYDHQTEELNLWLRGCRAALLNYYSSLMNSMGVVTLLVWLFEVSITAGLRYLHTALESVSNPEDPECESEGWLLEKSVPETWKAFLESFKKLGKSNQVEAEGADAGPAPEAG
What is the function of this protein?
Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:6715580).  Required for the maintenance of retinal outer nuclear layer thickness (PubMed:6715580, PubMed:29961824).  Required for the correct development and organization of the photoreceptor inner segment (PubMed:6715580).
What are the official names of this protein?
Peripherin-2, Retinal degeneration slow protein.
What is the protein family that this protein belongs to?
Belongs to the PRPH2/ROM1 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.