PharMolix/UniProtQA huggingface dataset:
Protein: RAMA_STRCO
Sequence: MSPAAGAPGSGPGRRRLPALDVRRFSPVRKSRPVPPRAPGRALEVLVLLCSVAAAVAAVAQPLALGRTLDLLLRDGDAGWWLPLSAALLLGELLLDSATSLFTGRCNATWTASVRTRALRGLLRTAPEHARPYPPGDIGTRLTLNAADAGGAPAARAALAASLITPLGALVALALVDVWVALCVLTGLPALALLLRSFARDTGATVAAYQRTQSLIASRLLEALEGADTIGAAGTGERERARVLAPLAELAAQGRHMWALHGRALGRSGVLVPLLTLAATAVGGLRLAAGELSVGDLLAVGRYAQLTAGVGAAASLLGAIVRAREARRRTRELERMTATVYGTRRLPPNGPGELRLCGVRVLRGGREVLRADGVRVPGGSTVAVVGRSGAGKSVLAAVAGRLIDPDEGYVLLDGVRLDRLTHEALRTEVAYAFERPVLGEGTIAEAVADGARRSSRERVRQAARAAGADGFVRRLPHGYDTPLPRAPLSGGEHQRLGLARAFAHAGRLLVLDDATSSLDTATEHEVDLALRRSVRPGTRLVVAHRPSVADRADLVLWLEDGQVRAVGTHRELWHTAGYREVFGAGAGAGAGAGAGAGADAGAGADAGPGPDSGAATAVGGSGPGPVRRPEPEEARP
What is the function of this protein?
Probably involved in exporting SapB from the cell (Probable).  Expression of the ram locus (ramA, ramB and ramR) induces rapid aerial mycelium formation in S. lividans (PubMed:8206859).
What are the official names of this protein?
ABC transporter ATP-binding protein RamA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GHT3_SCHPO
Sequence: MNRFITSILVVFISMSGWLQGADTGSISGILGMRDFQSRFADRYNPISNSYSYSAWRQALLTGTINAGCLFGAMLSSPFTERIGKKYSICFFSGVYIIAELLLVTAVPSWIQVLVGKILAGVGIGALSVLSPGYQSEVAPPQIRGAVVATYQIFSTGAALVAACINMGTHKLRKTASWRTSFGINMLWGILLMVGVLFLPESPRYLIYKGRDEEALRIMCNMAELSPESEIIQTNFNTIKSDIEIEMAGGKARWIEIFGKDIRYRTCLGFLVMLFRELIGNNYYFYYATQVFKGTGMTDIFLPAVILGAINFGTTFGALYTIDNLGRRNPLIFGAAFQSICFFIYAAVGDRKLIYKNGTSDHRAGSVMIVFSCLFLFSYCCSWGPMGWVIVGETFPIRYRSKCASVATSGNWLGNFMISFFTPFINNAIGFKLGYIYACINLFSSFMIFFLAKETKGLTLEEVNDLYMSNIKPWESYKYVREIESHRIHFSKEEEKREREKSKGIRGQEEEFIENADEDNNDSSSSSGSVVSAVKPRRSAVSNDRFSEDSHPTYI
What is the function of this protein?
High-affinity gluconate transporter.
What are the official names of this protein?
High-affinity gluconate transporter ght3, Hexose transporter 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UNG_BREBN
Sequence: MTTILQNDWAPVLADEFEKPYYVKLRQTLKEEYQTQTIYPDMFHIFTALHLTEYQNAKVVILGQDPYHGPGQAHGLSFSVKPGIKPPPSLVNIYKELKSDVGFEIPQHGYLNHWAKQGVMMLNTVLTVRRGTPNSHKDIGWETFTDRIIHLLNDRETPLVFILWGKHAQEKAAFIDRNKHFVIASPHPSPFSANRGFFGSRPFSRTNEFLRSRGLQEIDWQLPMQVEEE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPA_CHICK
Sequence: MPRPKPRSPRRRGRPPPAAPPPPPARPRARRYRPGQRALREIRRYQSSTALLLRRQPFARVVREICLLFTRGVDYRWQAMALLALQEAAEAFLVHLLEDAYLCSLHARRVTLYPKDLQLARRLRGLQGEGF
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550).  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).  Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271).
What are the official names of this protein?
Histone H3-like centromeric protein A, Centromere protein A, CENP-A, GgCENP-A.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.
Protein: MSMOB_DICDI
Sequence: MESLSLKFIEPYWFKFVDYYGEDFLITYGTFIAHEVFYFGSFIPFFLCDFMPFLQKYKIQPTKKNEWKTQFNCIFKVLMTHIFVQLPMMYIFDPAIKAIGLSARAPLPSIPYLIFTIACCFLIEDFYFYWVHRALHHGFWYKHIHKVHHDHAAPFGMTAEYAHPLETVILGVGTVIGPFLFSRDLFTLWVWLGTRLFQTVECHSGYDFPWNPTKLIPFWGGSHFHDFHHETFVGNYSSTFTYLDKIFGTSDKYYSRKQIRDSKLAAGKSE
What are the official names of this protein?
Putative methylsterol monooxygenase DDB_G0269788, C-4 methylsterol oxidase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RSD_SHIB3
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_MARN8
Sequence: MSFTVVIPARYASTRLPGKPLAMIAGKPMIQHVCERANESRASRVVVATDDARIEEACRGFGAEVIMTSPNHASGTDRLEEVARKLQLDPDHRVVNVQGDEPLIPPELINQVADNLEQYQEAAIATLCERIHDARQVFNPNVVKVVFDARGMAHYFSRAPIPWARDFWPAGAATQDVDLPDGIGYFRHIGIYGYRASVLSEFVTWLPAPTERVESLEQLRALYNGALIHVDVADRPPAPGVDTEEDLARLRALMEKGGARG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTT1_ARATH
Sequence: MESLLECFAITDGKCHPDCLKANNEQEDYDACQSAALVAVSLISSARVIFKIDSKYTEYSPQYLVDNVGKEEVEGEMDQPSCQYTVGNLLSYLVENVWTKKEVRQREMDQQRREFTVKDCFEFAFKKGLPRNGHWAHVGCIFPVPPFACQIPRVPMKGEVIEAANVSEALKLGMQQPAAARLHLFSPEFDLVGEGIYDGPSGNETRYVGLRDVLMVEAEKIKGETVFTVQICYKKKTSFVKVSTRSMILPLNGDDESQVTEPACLLVDFCIPRFSIN
What is the function of this protein?
Mediates both basal and acquired thermotolerance via HSFA1s-directed pathways (e. g.  HSFA1A, HSFA1B, and HSFA1D).  Triggers the expression of HSFA1A and HSFA1B.
What are the official names of this protein?
Protein HEAT-INDUCED TAS1 TARGET 1.
What is the protein family that this protein belongs to?
Belongs to the heat induced plant HTT protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: P4R2A_DANRE
Sequence: MEIDTLLGAFRDFEKKGEKESCPILDQFLSHVAKTGETMIQWSQFKSYFLFKLEKVMDDFKASCPEQRGPANPNVEYIPFEEMKQRILKIVNGYNGIPFTIQRLCELLTEPKRNYAGTDKFLRGVEKNVMVVSCVYPTSEKKGSSCVNRMNGVMFPGNTSAFPDRNVNGPGTPRPLNRPKHSLSSNVATNGLPDSTESKEQASEQSERTVNESSASEAESHSGAVKSKHRDDEDATHAETHEAKRLKFDKEEEEEEDDEEEDEDGDEIKKELDEPHSPCTSVAESSSDVPQSSTDVTAEVKDEDQEPSSTQSEVVENGVDRSTSEDSPDPSHKATGSESDPKEQQAEEEEEEESAEAQETEETNDPVSSSSNNSSDEGVSSAETPSASPSSSTELPAEGSVTAEITSDNSETADDNMEQD
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4C).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 2-A.
What is the protein family that this protein belongs to?
Belongs to the PPP4R2 family.
Protein: YND2_SCHPO
Sequence: MSNFDDLQILDQLQTSARFRGDTRIRRFKGSNNSKSPFGLNPSSRISQWPRITFIRAKDNYNPAEELCQLIDEQNAHNEAKHQSKEIMLPKETNVKSCEDLSKTGEIKALDIVLFKAITSKGDTLKVKKIPEYAEAFDTTKNVEVSSFPEKSMNENVLIQHSLNLAPSDKEISSTEESEQLCYKEQESEKELYSKDNDDSLDILNVPNLVNDDIANNNAAPPPPLAQAQEQLSTENEDEFDIDDTTDKMTTFTMNKFADLSVLEEDDDDEDEDEELEGEKEEEEEEKEKPEISNYDETEGKVNFSLEDSESLEFDEGSDDYDYAKLTTELVGNTDSLAEDEDDILEEDEDEDEEELLAIFDASDDSEIEAYLSIGDTLQNDFTIYDYDSEDEEYNNPSTQKTEKVSQSKKGAKVKEEKGLKKDRKLPKKMRKAQKKLERKAGKAVAARMGDAFSNSLDDESMNLYAELQEQWLKDKSKKARRRAEREKLRSEGLLGKKSKKKLLRESQKPSSSDSDNASLTRIDKIFINDVYQRMQQFKHSAIEEISLPPCRKYVRRLVHALANDLNLKSRSYGSGNKRYTMLSKTHKFDASSVDLVSLTRIMERLQTRVEYQSFSKSGRKSRMTVSSVRSSKATRVYDGQIVGEDAPEISKENPGRRLLEKLGWYAGKGLGHPENEGSKDSLRAIVKVSRSGLG
What are the official names of this protein?
G-patch and R3H domain-containing protein C30B4.02c.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLA1_ORYSJ
Sequence: MPPKASKKDAAPAERPILGRFSSHLKIGIVGLPNVGKSTFFNIVTKLSIPAENFPFCTIDPNEARVYVPDERFDWLCQLYKPKSEVSAYLEINDIAGLVRGAHAGEGLGNAFLSHIRAVDGIFHVLRAFEDKEVTHIDDSVDPVRDLETIGEELRLKDIEFVQNKIDDLEKSMKRSNDKQLKLEHELCEKVKAHLEDGKDVRFGDWKSADIEILNTFQLLTAKPVVYLVNMSEKDYQRKKNKFLPKIHAWVQEHGGETIIPFSCAFERLLADMPPDEAAKYCAENQIASVIPKIIKTGFAAIHLIYFFTAGPDEVKCWQIRRQTKAPQAAGTIHTDFERGFICAEVMKFDDLKELGSESAVKAAGKYRQEGKTYVVQDGDIIFFKFNVSGGGKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP (Potential).  Exhibits GTPase activity (PubMed:19086295).  Exhibits similar binding affinities and hydrolytic activities toward both GTP and ATP (PubMed:20876569, PubMed:26912459).  Binds to the 26 S ribosomal RNA in vitro, but not to the 5. 8 S or 18 S rRNA (PubMed:20876569).  Confers sensitivity to salinity stress by suppressing the anti-oxidation enzymatic activities and increasing lipid peroxidation thus leading to the accumulation of reactive oxygen species (ROS) (PubMed:23550829).
What are the official names of this protein?
Obg-like ATPase 1, Ribosome-binding ATPase YchF, OsYchF1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Cytoplasm, cytosol. Note=Localized mainly in the cytosol under NaCl treatment, but translocates to the plasma membrane upon wounding.
Protein: CLPX_CLOBH
Sequence: MSKLDEKKQLKCSFCGKTQDQVRRLIAGPGVYICDECIELCSEIINDEFEDDIQVDLTSLPKPTEIKTYLDQYVIGQEDAKKSLSVAVYNHYKRINSNTNNDDVELQKSNILLLGPTGSGKTLLAQTLAKFLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDIEKAEKGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVAAVPPQGGRKHPHQEFIQINTTNILFICGGAFDGVDKIIERRTRTSSLGFGAEIQSKKEKDLGKLLKDIMPGDLLKFGLIPEFIGRLPIVVTLDKLDREALIKILTEPKNALVKQYKKLFELDDVELEFNQEALKEIADEAINRNTGARGLRAIIEDMMREIMFDIPSQENIGKVIVNEDCIKTKKPELIEAEGGKRLPIKPKKGKKRKDSETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TIAS_ACIS3
Sequence: MEHQLLSVAIDDTDSQYGGCTTHLTGLILKELGNRALLADYPLLVRLNPNIPWRTRGNAATVLRLLYDGDPKELMETLWSIIEEYTEPRPPLPGKSPGLVVAPGSPWESERLRWLYRKALSDVVTLDVATESLSKYGALWRGGRGVIGAASSLAALSPGEPYTFELTFYRRPENWGSRRCVYSDKVAYLEGQSSGTLNNLELDEGTTSAAPGGPDPVLAGFRGTDPGELWRFDEALCERPHFAVLYRSNQHTGVHLQAQEPRIYRSVNITVTVRSPPLKLPGGHVIVEVSDGVNTYDAAFYEDSGPLARAAELLYPGDVIIIAGGVRPYSPRGKLTISVEAMKVVGVAQRRVQVPPRCPRCGARMESLGRGKGYRCPRCGLRSSGHKQSLVVERELLPGSYYYKIGRARHLSPVGARLPTMDRLPVTINVSDVLRVY
What is the function of this protein?
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
What are the official names of this protein?
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS, tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the TiaS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHED_BDEBA
Sequence: MLPVEHHVRIGQILIAENGEVLKTVLGSCVGIALVWRRQNKWALAHCLLPYPETFKEDKEARYVSQTIPRMLERMGATMADVSELEAIVAGGGRMMDGDKNYIKFVVGDENLKAAKAVLEKHRIRIVAFEPGGEQGTKMRIAGDGDYSIEKLPKTA
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: DEF_AGARV
Sequence: MALRTIRVEGDPVLGKVCREVTEVTPKIVTLIDDMLETMYEANGVGLAAPQVGILKRIVVIDVGEGPIVMINPEIIESDGEQTGDEGCLSVPGKAGQVTRPNYVKARFMGEDMNEYEIEGEELLARCICHELDHLDGHLYVEKVEGALHDVTYEDTQE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: O16K_CONPE
Sequence: MKLTCMMIVAVLFLTAWTFATAEDPRNGLENLFSKAHHEMKNPEDSKLNKRCVKYLDPCDMLRHTCCFGLCVLIACI
What are the official names of this protein?
Conotoxin PnMKLT1-0122.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CHM6A_XENLA
Sequence: MGNLFARKRRSRVTEQDKAVLQLKQQRDKLKQYQKKITLQLQRERELAKQLLHDGKKEKAKLLLKKKRYQEQLLEKTDNQISNLEKMVEDIEFAQIEMKVIEGLKVGNECLKKMHEVMSIEEVERIMDETQEGIEYQRQIDEMLSGSLTAEDEEAILEELEAITQEDLELPEAPSEPLPDTIPEKQAVKNKPKPQMIAAS
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 6-A, Chromatin-modifying protein 6-A.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Endomembrane system; Lipid-anchor. Late endosome membrane.
Protein: PSBF_OLTVI
Sequence: MANQKTYTYPIFTVRWLAIHALAVPTVFFLGSITAMQFIER
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PLA22_ORYSJ
Sequence: MRFFLKLAPRCSVLLLLLLVTASRGLNIGDLLGSTPAKDQGCSRTCESQFCTIAPLLRYGKYCGILYSGCPGERPCDALDACCMVHDHCVDTHNDDYLNTMCNENLLSCIDRVSGATFPGNKCNVGQTASVIRGVIETAVFAGKILHKRDDGQ
What is the function of this protein?
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli.
What are the official names of this protein?
Probable phospholipase A2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: OPSO_RUTRU
Sequence: MELFPVAVNGVSHAEDPFSGPLTFIAPWNYKVLATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYFGIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNFHDHTFIIAFFITCFILPLGVIVVCYCKLIKKLRKVSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQFRKCLVQLLRCRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIPKDGSIPEKTQEHPGERRSLAHIPIPENKVCPM
What are the official names of this protein?
Opsin-VA, Vertebrate ancient opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SPEE_SHISS
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGIVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSYRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAIHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_LACCB
Sequence: MAKKSKIAKAKRQEKLVKQYATKRAALKAKGDYIGLSKLPRDSSPVRLHHRDVLDGRPHAYMRKFGMSRLNFRELAHKGQIPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: THIE_METM6
Sequence: MKFKDKLKFYVITDSNYSDEVISVEEALKGGASSIQLRMKTSSTRKMIEVGNKLRKLTSEYDALFFVNDRLDVAQAVNADGIHVGIDDMPISKIKEIAPNLIIGASAYNTDEMKTAEMGGADYLGVGAVYSTNTKLDARNLGLDGLKNISKIASIPIVAIGGINHLNVENVLECGVSGVAVVSAIVGAENILKSAENMNELIKKYIK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: BPTA_BORBD
Sequence: MRKILFFGLLSICFLFVFFFYKQKENKIIYNKIVEKFEDNVVIDETYTHLFKDSNLKELVFIKSRLIIPELEHKKMMKATGYRADAYRALSTVYKFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
What is the function of this protein?
Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the spirochete.
What are the official names of this protein?
Protein BptA, Borrelial persistence in ticks protein A.
What is the protein family that this protein belongs to?
Belongs to the BptA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RBS_SINMW
Sequence: MRITQGCFSFLPDLTDEQITAQVEYCLGRGWAIGVEYTDDPHPRNTYWEMWGNPMFDLRDAKGVMMEVEDCRKAHPQDYIRLNAFDSSRGLETVTMSFIVNRPENEPSLRMTRTESDGRSQHYTWETQR
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
Protein: IRF3_BOVIN
Sequence: MGTQKPRILPWLISQLDRGELEGVAWLGESRTRFRIPWKHGLRQDAQQEDFGIFQAWAVASGAYTPGKDKPDLPTWKRNFRSALNRKEVLRLAEDHSKDSQDPHKIYEFVNSGVRDIPEPDTSQDNGRHNTSDTQEDTLEKLLSDMDLSPGGPSNLTMASEKPPQFLQSPDSDIPALCPNSGLSENPLKQLLANEEDWEFEVTAFYRGCQVFQQTVFCPGGLRLVGSEAGDRMLPGQPIRLPDPATSLTDKSVTDYVQRVLSCLGGGLALWRAGQWLCAQRLGHCHVYWAIGEELLPSCGHKPDGEVPKDREGGVFNLGPFITDLITFIEGSRRSPLYTLWFCVGQSWPQDQPWIKRLVMVKVVPMCLRVLVDIARQGGASSLENTVDLHISNSDPLSLTPDQYMACLQDLAEDMDF
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses.  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.  Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction.  Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases.  This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.  Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
What are the official names of this protein?
Interferon regulatory factor 3, IRF-3.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection.