PharMolix/UniProtQA huggingface dataset:
Protein: ISPG_CHLPN
Sequence: MTLITPAINSSRRKTHTVRIGNLYIGSDHSIKTQSMTTTLTTDIDSTVEQIYALAEHNCDIVRVTVQGIKEAQACEKIKERLIALGLNIPLVADIHFFPQAAMLVADFADKVRINPGNYIDKRNMFKGTKIYTEASYAQSLLRLEEKFAPLVEKCKRLGKAMRIGVNHGSLSERIMQKYGDTIEGMVASAIEYIAVCEKLNYRDVVFSMKSSNPKIMVTAYRQLAKDLDARGWLYPLHLGVTEAGMGVDGIIKSAVGIGTLLAEGLGDTIRCSLTGCPTTEIPVCDSLLRHTKIYLDLPEKKNPFSLQHSENFVSAAEKPAKTTLWGDVYGVFLKLYPHHLTDFTPEELLEHLGVNPVTKEKAFTTPEGVVVPPELKDAPITDVLREHFLVFHHHQVPCLYEHNEEIWDSPAVHQAPFVHFHASDPFIHTSRDFFEKQGHQGKPTKLVFSRDFDNKEEAAISIATEFGALLLDGLGEAVVLDLPNLPLQDVLKIAFGTLQNAGVRLVKTEYISCPMCGRTLFDLEEVTTRIRKRTQHLPGLKIAIMGCIVNGPGEMADADFGFVGSKTGMIDLYVKHTCVKAHIPMEDAEEELIRLLQEHGVWKDPEETKLTV
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: SPEM1_MOUSE
Sequence: MAMAERPRPGWASYQNPNINNCQDMGNSILLLLGLIVCINIGINLVTLLWSRIRILLHRMFHIICEKETSTSLGKLVQPLRKQTYPKVHLRCTMDPVKMTVTPPPTRRRYRHRAPPSRRARCPIAWAPDTDDEKPPHQHPAICSRHWNDSKDWEGFQSMQEVWEPWTQDGLEQPPQTIRFQPAVEARPLKSEIRSDQGLEAYVYTVNPPPPSPEALSHKNNAAGSGGCVEGEQAQGQPVSPSFLGPANVPEIPRRHSSGRIVYDARDVRRRLRELTQEVEALSHCYPLVSGSSAAEGTGKDWVYRPLKGR
What is the function of this protein?
Required for proper cytoplasm removal during spermatogenesis.
What are the official names of this protein?
Spermatid maturation protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm.
Protein: ILVD_TRIL1
Sequence: MRSDMIKKGLERTPHRALLKATGIPQSQMERPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAQFFGIPGVCDGIAMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLNIPCIIVTAGPMMSGRGVEGRAYSFVTDTFEAMARYKAGVIDAKELQVCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSAMKRRIAFASGEKIVELVHNDVKPRDIMTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILAKETPQLASMNPAGKHFMEDLDIAGGVCGVLKQLGDKIIDTRTLFGLTTRQLAASIENVDQEVIRPLSAPVKKEGGIAVLFGSIAPKGAVVKQSGVSDKMMLFEGTARCFDSEELAMAALMEGVIKAGDVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHVSPEAAEGGPIALIQDGDRILLDIPNRKLDLLVDGATIEARRAQWTAPEPKIKTGWLARYAKVVTSAYTGAVTTAD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NCAP_I27A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELVRMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSNTLELRSRYWAIRTRSGGSTNQQKSSAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRISDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CDC6_METB6
Sequence: MPETEDPATGLFIKYLSNNRIFRDREVLRHSYRPQILPHRQPQIDTIASILAPSLRNETPSNILIYGKTGTGKTASVRYVGSELEKASSTMGTTCRIVHLNCEVIDTQYRVLAQIAKCIDDVDEASSDKAKIHIPMTGWPTDQVYSELKNQLDTGGGVLVIVLDEIDKLVKKSGDDTLYNLTRINSDLKNSKVSIIGISNDLSFKDFLDPRVLSSLSEEEIVFPPYNAPQLVDILTQRAAGAFLDGAIADGVIPLCSALAAQEHGDARRALDLLRISGELADRDESKQVTDVHVKQAQAKIETDSMIECIATLPTQSKLILFSMLTLEQLGQNIFTSGEVSRVYQDIAPEIQLDILTHRRITDLISELNMLGVINTRVVSRGRYGRTKEMWFDANTGKIREVVLKDPRLNGLKDLDINQMETKWLKTWFR
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: RL333_STAA9
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: GLR12_ARATH
Sequence: MVRICIQTPILLSFLLVLLFFISNCFASSQNNDDDKRIRVRVGLVLDLGSVEGKIVRSSVSMALSDFYDNHNDYKTRLSLLVRDSHGEPLLALDSVVDLLQTEGVQAIIGGNSLLEAKLLAELGEKARVPVISLNSPMSLSLSKYTHLIQATHNSASEVKGITAFLHGFDWNSVALVLEDHDDWRESMHFMVDHFHENNVHVQSKVAFSVTSSEDSLMDRLRELKDLGTTVFVVHLSEVIATRLFPCAEKLGMMGEGFAWILTSRSMSSFHDQFIDDLTKEAMEGVVGFKSYIPMSKELHNFTLRWRKTLPVEEVTGSEITRLSISGVWAHDVAWSLASAAEVTRMPTVTSTLLEAIKESRFKGLSGNFQLDDMKLLSDKFEIVNMIGSGERRVGFWNSNGSFSNRRQLSSTHDNLETIIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNRFPRLMKVETDPITHEITIVEGFCIEVFQASIAPFNYEVEYIRWLNGTNYTKLAYALHSQKDKYDAAVGDITITSDRSMYVDFTLPYTEMGLGIVAAKERSMWVFFQPLTPNLWITSAAFFVLTGIIVWLIERAENKEFQGSWPQQIGVVIWFGFSTLVYAHREKLQHNLSRFVVTVWVFAVLILVTSYTATLTSMMTVQQIRFNANEDYVGHLSGSLIANAALTNSSLRAMRLLGLNTSEDYAQALMNKSVSYIVSELPYLKILLGENPGHFLMVKTQSTTNGFGFMFQKGSELAPNVSREIAKLRTSERLNEMERRWFDKQLPYTTDDTSNPITLYRFRGLFMITGVSFAFALAVLLILWLRERWEILVNSVNIYFSQRLRHFRILFTRTIHPSPLGLDNPIGENAVQMAQRNRR
What is the function of this protein?
Glutamate-gated receptor that probably acts as non-selective cation channel.  May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
What are the official names of this protein?
Glutamate receptor 1.2, Ligand-gated ion channel 1.2.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IEND2_USTMA
Sequence: MVLNDKVYENISPQTLACWFMDDGGMNGSHSHGLQFRVSVILK
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded DNA endonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RLMD_PSET1
Sequence: MAQIFKATKKPLKQQSLVLDITAMDHHGRGIAKHNNKVCFVSNALPNEQVKATIIADKARYSEAQTHKVLQASEYRVAPFCEHYNQCGGCQLQHLDSSQQVVEKQIAVSKLFEKFAKLDELNWQAPLLSKATHYRRSARLAVMFDKKAKKMHVGYRASGSKSIISINECPVLSEVFANVFTVFDNLINQHKALHSVSHLQLCQGDEQNFVIIRHTKPISEDIKALVAQSAAEQQWQLVWQSESEVIEHSHLAMPFYALEELGLKFEFGLNNFIQVNASVNQAMLKQAQNWLALKGDENVLDLFCGIGNFSLVLAKQAKTVIGVEGVASAVAMATQNAHTNSITNAQFNCFDLTNKIETASWFNKNLDVLVLDPSRTGAITVLEQLPLKQFKTILYVSCDPVTLARDSAIISQAGFELHKIGLMNMFPHTGHIETMALFQRR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RL7A_METJA
Sequence: MAVYVKFKVPEEIQKELLDAVAKAQKIKKGANEVTKAVERGIAKLVIIAEDVKPEEVVAHLPYLCEEKGIPYAYVASKQDLGKAAGLEVAASSVAIINEGDAEELKVLIEKVNVLKQ
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAP_BACSU
Sequence: MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFLVFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLIPVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLKLGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTMKKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGLAYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG
What is the function of this protein?
Part of the ABC transporter complex AraNPQ involved in the uptake of arabinooligosaccharides.  Transports alpha-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units (PubMed:20693325).  Responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Arabinooligosaccharides transport system permease protein AraP.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_SHESR
Sequence: MSNIPTELKYASSHEWIRKEEDGSYTVGITEHAQELLGDMVFVELPEVGDTVTAGNDCAVAESVKAASDIYAPISGEVIAVNEALEDSPELVNSDAYGEGWFFRVMPSDESEVDALLDAEGYQAVIDEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SERP3_DANRE
Sequence: MPQLSASSLFICLWLVDLCHVANSVLSSSFSDLHTQFGISLYQTLTETENKSNLIVSPASVSLCLGLLQLGARGNTLVQLEGTLGYDVNDVRVQNILSRPQGDLANSSEGLRLQLANALFIQTGVKLLPEFTQHALGWGNTSLLSVNFSNPNHTHSRLQQWAHYQSKADDHLQTREELHHSSGEEEEATRQDHLLYMALVSTLVFHGAWQKQFLFTETQNLPFTFSDGSTVKVPMMYQSSEVNIGHFRLPSEQEYTVLELPYLDHSLRLLVALPSDRKTPLSQLEKQITARAVGLWDTGLRRTKMDIFLPRFKMQSKINLKPVLQSLGVSDIFSPSAADFRGISDTDGIFVSEAFHEARIEVTEAGTKAASATAMVLLKRSRSAVFKADRPFLFILRQISTGSLLFIGRVVNPADMP
What is the function of this protein?
Probable serine protease inhibitor.
What are the official names of this protein?
Probable serpin E3.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS7_SALTI
Sequence: MSQKYLFIDRDGTLISEPPSDFQVDHFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLGTQSFPQADFDGPHNLMMQIFTSQGVCFDEVLICPHLPADDCDCRKPKVKLVERYLAEQAMDSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGEQLTKRDRYAHVVRNTKETQIDVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALGEALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARC_THEFY
Sequence: MADRDDERHAERDRDELVAQVSYLEKELSVLRRKLADSPRHVRLLEDRLQEAQTALAAANAKNERLVSALKEARDQIVALKEEVDRLSQPPSGFGVFLRARDDGTVEIFTNGRKMRVNVSPSVNVDELRPGQEVMLNEAFNVVEASSYETVGEVVMLKEILEDGERVLVISNHDEERIVRIAEPLRDEPLRAGDSLLLEPRSGYVYERIPKAEVEELILEEVPDISYSDIGGLNGQIEMIRDAVELPYLHKELFREHKLRPPKGVLLYGPPGCGKTLIAKAVANSLAKQVAEKTGRDVGKSFFLNIKGPELLNKYVGETERHIRLVFQRAREKASEGTPVIVFFDEMDSIFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAARDIFSKYITPDLPLHPDDLAEHGGSPTATVNAMIQRVVERMYAETEENRFLEVTYANGDKEVLYFKDFNSGAMIQNIVDRAKKMAIKDYLENGSKGLRVSHLLQACVDEFSENEDLPNTTNPDDWARISGKKGERIVYIRTLVSGKKGADAGRSIDTVANTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: RL40B_ARATH
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIIEPSLMMLARKYNQDKMICRKCYARLHPRAVNCRKKKCGHSNQLRPKKKIK
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40-2, Protein EARLY-RESPONSIVE TO DEHYDRATION 16, Protein EMBRYO DEFECTIVE 2167, Protein HAPLESS 4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40-2]: Cytoplasm.
Protein: TRXR1_PIG
Sequence: MNGAEELPEMYDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVSCIPKKLMHQAALLGQALRDSRNYGWNVEETIKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYENAYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
What is the function of this protein?
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form.  Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.  Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis.  Also has reductase activity on hydrogen peroxide (H2O2).
What are the official names of this protein?
Thioredoxin reductase 1, cytoplasmic, TR, Peroxidase TXNRD1, Thioredoxin reductase TR1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TREA_KLULA
Sequence: MDGKVNNNPPRSRHRRTSSLEEVVDPFSTPDVYYGPKSDPSKLLSKNRFTRTRTFSVAEPGGGKGHSSSYTSPYFDTTVPLRRRGSEDDSYSASQGQRRFYIEDVDKTLKELLASEDTDGNYQITIEDTGPKVIRVGTVNSNGYKHVHIRGTYMLSNLLQELTLAKLFNRKQVILDEARLNENPVNRMTRLISGQFWKSLTRRIDSNNIAKIAYDTKIDTPKAKNPRIYVPYNCQDEYQQLVQWSEMDPSLQLEVNYLPKDITPEFVKSLNDKPGLLCLAMESHMDPVTGEETWVGFPYAVPGGRFNELYGWDSYFMALGLLESNKLDVARGMVEHFIFEIDHYGKILNANRSYYLCRSQPPFLTDMALQVCRKMGGDKNPVAVDLLRRAFKAAIKEYLTVWTASPRLDEKTGLSCYHPDGIGIPPETEPGHFDSILRKYAEKYNVSIPEFRDLYNSQKVHEPDLDVFFLHDRGVRESGHDTTYRFENVCAYLATIDLNSLLYKYEVDIAYVIKKYFGDNFEGLPEGHRTSNDWEKLAEVRKERIDKYLWDEETGFYYDYNVKTEKRTSYESVTTFWALWAGMSSQEQAQRMVENALPKLEEFGGLVACTARSRGELSLDRPTRQWDYPFGWAPHQILVWDGLVRYGYENHTRRLAYRWLFLMTKAFVDYNGIVVEKYDVTRGTDPHRVDAEYGNQGADFKGVATEGFGWVNSSYLLGMKYMNNFARRALGTCVTPKVFFGRLPPKEKKKYGLE
What is the function of this protein?
Hydrolyzes intracellular trehalose to glucose (Probable).  The disaccharide trehalose serves as a storage molecule for energy and carbohydrates that is mobilized during nutrient stress (PubMed:9075620).
What are the official names of this protein?
Cytosolic neutral trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase, KlNTH1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL020_YEAST
Sequence: MNSIRKLSCFGTGSSIYSGKCLSSTQQKGLPQRTLWTMNGLIWAYWMMVLQLIIIPKDSGCSRSTFLFFFSHLLLVPFFFFLTLLFHFPVFNNISLNFYIQ
What are the official names of this protein?
Putative uncharacterized protein YLL020C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KDUI_SALPA
Sequence: MDVRQSIHSEHAKTLDTQALRREFLIENIFVADEYTMVYSHIDRIIVGGIMPVSHPVEIGGEVGKQLGVSRLLDRRELGVINIGGAGAIIVDGQRHDIGHRDALYISKGAKELVFVSNEASRPAKFYYNCAPAHTAYPTKKVSPADVAPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYLYFNMEEDSCVFHMMGQPQETRHIVMRNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVQDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: MOAC_METLZ
Sequence: MPVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQVAGTLAVKQTWALIPMCHPLPVGGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLSLLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Probable cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: CRYAB_COLLI
Sequence: LIRRPLLSWLAPSRIFDQIFGEHLQESELLPASPSFSPFLMRSPILRMPSWL
What is the function of this protein?
May contribute to the transparency and refractive index of the lens.
What are the official names of this protein?
Alpha-crystallin B chain, Alpha(B)-crystallin.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: ATNB_ARTSZ
Sequence: MSSWAITGASRGIGFEFAKQLSADGSNQVFALIRSEPSAELAELSSGRENLHVIQADVTDAQGLSEAAAKVGELTGNKLDVFISNACHPGLDLRFHPTSAFLGKEKELKEEIDACMNVNLLGAINSINCFLPLIRNGELKKIIYITSPSGDAEFTRKCGVTVTVGYSITKAAMNLVMSKYAAELKGEGIKTLSLSPGWVDTDGTRDMAPTPEILEMALQVFQKFKPDLTGLMSVEESVRMQLNVINGLTVKQSGLALSHHGDYNWL
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids (PubMed:29797385).  The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids (PubMed:29797385).  The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (PubMed:29797385).  The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA (PubMed:29797385).  The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (PubMed:29797385).  The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable).  The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster (PubMed:29797385).  The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable).  For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase atnB, Arthripenoid biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UBC9_XENLA
Sequence: MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
What is the function of this protein?
Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4.  Essential for nuclear architecture and chromosome segregation.
What are the official names of this protein?
SUMO-conjugating enzyme UBC9, RING-type E3 SUMO transferase UBC9, SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-protein ligase I.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAGB_BACAN
Sequence: MNILVVKTPEELAEAGYKLIEEVVKTKENPTLGMATGSSPLGIYAEMRKNKLDTSRVTTVNLDEYVNLPHEDKNSYHYFMQEQLFDHLPFKQTYVPNGMASDLEEECKRYEGILAANPVDLQILGIGENGHIGFNEPGTPFNSPTNIVELTESTRQANLRFFEKEEDVPTHAITMGIGSIMKAKQILLVAMGSKKAEAVKELLQGAYSEACPATVLQRHPNVTVIADQEALSLCSEAIADEHRQVFTISDLLSDSRVGETAN
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: IL4_CAPHI
Sequence: MGLTSQLIPALVCLLVCTSHFVHGHKCDITLEEIIKMLNILTSQKNSCMELPVADVFAAPKNATEKETFCRAGIELRRIYRNHMCLNKFLGGLDRNLSSLASKTCSVNEAKTSTSTLRDLLERLKTIMKEKYSKC
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.