PharMolix/UniProtQA huggingface dataset:
Protein: HUTG_STAAE
Sequence: MYKQGEPNLWTGRLDSETDPKKFRHFQTVTFEDLSKLEKSSMPSGVGILGYAVDKGVALNKGRIGAKEGPDAIKQAFAGLPDLNQCETLVDYGNVYHDHEELIDTQKEFAMLAAKSIANHRQTFLLGGGHDIAYAQYLATRKVYPTQSIGVINIDAHFDTRAEQQSTSGTSFRQILEEDENTDYLVLGIAQGGNTQSLFDYAKEKKIDYVFADELLSHVSPTIKDMIERFVHEHDVIMFTICMDVIDSAFAPGVSAPAVLGLYPHTVLELAKRIIPSDKVSSVSIAEMNPTYDADNRTAKLVANLVHHFLK
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: AMT5_ALTAL
Sequence: MASYGFPLTASSLVDWTSLTFSPIEVNGHIQCTYSPEVAEWGAPHFVKDPYLRVHGLAPALNYGQQIFEGMKAFRTPTGSIRLFRPKMNAVRFAHSASFVAIPPVPEALFLRAVHLAVGLNSEFVPPYDSRGSALYIRPIAFASSATVNLAPADHFTFCVFVMPVAPLSTGAGQGLRALVVEDVDRAAPKGTGSAKVGGNYAPIVTTMQRAKADGYGLTLHLDSATHTMVDEFSASGFIGVRVDAGKTTMVVPDSPTILRSITVDSMCRIAESFGWQVQRRAVSFTELAELSEAFAVGTAFILTPVRAITRPCTHTCIEYTADYRSSASAYTRLLETLQGIQQGWLDDAWGWTEEVQDPSSDEFITDTVQARR
What is the function of this protein?
Transaminase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (Probable).  AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III.  The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable).  AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization (PubMed:22846083).  The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin (PubMed:10875335).  The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol (PubMed:15066029).  The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet (PubMed:17990954).  Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression is highly up-regulated in AM-toxin-producing cultures (PubMed:17990954).
What are the official names of this protein?
Transaminase AMT5, AM-toxin biosynthesis protein 5.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: RS20_HAEIN
Sequence: MANIKSAKKRAVQSEKRRQHNASQRSMMRTYIKKVYAQVAAGEKSAAEAAFVEMQKVVDRMASKGLIHANKAANHKSKLAAQIKKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PURL_BACAH
Sequence: MSLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGEGAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAKRPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQERMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLFHKGEMVAEVPADALAEEAPIYHKPSKEAAYFAEFQQMKMETPKVENYKETLFALLQQPTIASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEVGGKIAVAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVSMYNERSGEAVYPTPTVGMVGLVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMLHGKIFGQSPSIDLDVELKRQKQVLAAIQAGLVQSAHDVAEGGLAVAISESAIGANGLGATVKLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTNTNEVTIHNEENEVLLTANVDEMRKAWKGAIPCLLK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISK1_MOUSE
Sequence: MKVAVIFLLSALALLSLAGNTFSAKVTGKEASCHDAVAGCPRIYDPVCGTDGITYANECVLCFENRKRIEPVLIRKGGPC
What is the function of this protein?
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:9828198, PubMed:14645103, PubMed:16083722, PubMed:22228629).
What are the official names of this protein?
Serine protease inhibitor Kazal-type 1, P12, Prostatic secretory glycoprotein, Serine protease inhibitor Kazal-type 3.
What are the subcellular locations of this protein?
Secreted.
Protein: GAR2_MOUSE
Sequence: MMKKNRNKKAMNKQEALFIPHYYRLGHLKNILDGGEYAPYVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPIFKTPNMMLLAHLTPEARKEPEPLFKTLLKSSSSGTLVLTRFIPLQFVTLSVHSAKNMRLKVKLINGRSYYLQLCAPVYKQDIIFSQWVDLIPLLNQEKIKNTKVSEVSSLSELTNSTDIAGSMDITDITAFRELRPRHPKTHRYPCNIMESADFSEYTDVTDVTDVTDVTDMLDNGITDVQDIKIVTEVTEVTEVTEVTEVSEVSDVKMATNISGVKIVFENDDIIKTKQEEKEYTLKHRSLQDTKTKSDYQDSPNPVTMSNIALALQDEGCFQTTQTPVKSKEDIYKEICDETSEENMIRLQNIHLKATESRSTRTDSDISDGELKLGRYLHKQCSSREQSFIHSLGSLPRGFVFLHLLL
What is the function of this protein?
Seems to play a role in sperm motility.
What are the official names of this protein?
Golgi-associated RAB2 interactor protein 2.
What is the protein family that this protein belongs to?
Belongs to the GARIN family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=In mature sperm, localizes in the midpiece of flagella.
Protein: IMSP4_RUDPH
Sequence: HGNGYNSNNGNGYNSNNGNGYNSNNNGNTNCNFGNCNNANSFNNNGNTNSLNGNNNGNSNNNGNGNNNGNSNNNGNGNNNGNTNNGNSYDSNTNDDSNSIPNAVSVGGSNKLVIKTKSDDSSQTISLLDVFKNYDSNNNGNSNNNGSSYNRNDNGNSYNSNNNGNSYNRNDNGNSYNSNNNGNSYNRNDNGNSYNRNDNGNSYNSNNNGNTNSFNNNGNTNSFNNNGDTNRIDSNSYNSNNNGDNSNTNSVLVPEPTVIVIPAPVQQSVGCVCKPDYDPLLYTDNETYNNKCEAECEGKTVWYDKACY
What are the official names of this protein?
Insoluble matrix shell protein 4, IMSP4.
What are the subcellular locations of this protein?
Secreted.
Protein: PSTB2_LACJO
Sequence: MENIITSKDVHLSYGNVEALHGISLDFEEKELTALIGPSGCGKSTFLRCLNRMNDDIPNIHISGEIKFENKNIYGPKMDLVELRKDVGMVFQQPSPFPFSVYDNIAYGLRIAGIKDKELIDQRVEESLKQAAIWKETKDNLDRNAQAFSGGQQQRICIARALAVRPKVVLLDEPTSALDPISSSEIEETLLELKHDFTFIMVTHNLQQASRISDYTAFLMSGDLIEYGKTSDMFMNPKKQITSDYLNGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PGRP1_CAMDR
Sequence: MTRHCVLLVWALLALLSLGAAREDPPACGSIVPRREWRALASECRERLTRPVRYVVVSHTAGSHCDTPASCAQQAQNVQSYHVRNLGWCDVGYNFLIGEDGLVYEGRGWNIKGAHAGPTWNPISIGISFMGNYMNRVPPPRALRAAQNLLACGVALGALRSNYEVKGHRDVQPTLSPGDRLYEIIQTWSHYRA
What is the function of this protein?
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.  Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity.  Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane.  In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement.  Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system.  Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity.  Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
What are the official names of this protein?
Peptidoglycan recognition protein 1, Peptidoglycan recognition protein short, PGRP-S.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule.
Protein: RS9_ALISL
Sequence: MAENQYYGTGRRKSSAARVFIKPGTGNIVINKRSLEVYFGRPTARMVVNQPLELVEMTDKLDLFITVSGGGISGQAGAIRHGITRALMQFDETLRPALRAAGYVTRDARCVERKKVGLRKARKKPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CMR1_DEBHA
Sequence: MAPLSDFEKQRQENIQRNKDLLRKLNLDSATDSISREIPNQRQANGAKKRKTNNAAKPIKKEPQEPSRRSRRLAGVTMENTEEYQKVKEEMEEAERKKKELEKLKSTRLFGNFHLIDLVTDKRSGDMKFEKKVLKLPNEIKKEENNTKEIKEEEDDHLQDDDINIESDNKVLEILKDLGDKFSAGDFYDLIRNSSSDYDDKGLESKRNEFDNLKLFERFDPLDIKITHQRITAINFHPSKTDRVITAGDKVGNLGIWAVDSTEDEDPAITILKPHGRSIAKILTPHSNPSKIYSCAYDGSVRELDLNKLESSEVIYLKDPYESQDYPLAVSDINLCQEGNPNVLYLTTLGGHFYQHDLRTPFKSIKPNSLLRLHDKKIGSFCINPNLSHQIATASLDRTFRIWDLRNISKSNSSWSEYEDQISPHVYGSYSSRLSVSSVDWNYENRLVCNGYDDTINIFDLSSESSELPPVTEWSKTYQTGTKNKDEQIPTNIKPFTRIKHNCQTGRWVSILKSRWQASPGDGIQKFVIANMNRGLDIYDQKGQILAHLTDSEKVGAVPAVAAMHPIENWCVGGSASGKLYLFE
What is the function of this protein?
DNA-binding protein that binds to both single- and double-stranded DNA.  Binds preferentially to UV-damaged DNA.  May be involved in DNA-metabolic processes.
What are the official names of this protein?
DNA damage-binding protein CMR1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DDB2/WDR76 family.
Protein: TORD_HISS2
Sequence: MITLNTEEKIFIYSWLKNILSHELTEQQLQQYQQGVFTPLFDFLSEQDLAKQINTVRNSLMQLSNLPLAHLELAADFAQLFLLNGENSALPYASAYLSEKELNQHIAFIDHLLFKYQLKFDHNLREPSDHLAVYLELLITLEKSGQKEKSFNFIQHYLLAWLIPFNKKVQKIKTETSFYQAITEILITLLNKNVKLS
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC3_CANAX
Sequence: MSTNIKIIKKVLNGYVGFANLPKQWHRKSIRRGFSLNIMAIGESGLGKATLINTLFNRDIITSQHDSDEFDEGEEEDVSVKIKSTQAEIEEDGVKLKVSVITAPGFGESINNVEAWKPIVDEINSRFDSYLEAESRINRTAVVDNRVHAFLYFIEPTGHSLRALDIALMKQVHEKVNLIPVIAKSDTLTDEEILEFKHRILADISHQGIKIFKPTDFEYDEEESANTRSIIDSFPFAVVGSTNEVQTPDGRLVRGRKYPWGVIEVDNENHNDFVKLRQLLVRNFLEELKEHTANVLYENYRTEKLKRMGIEQDNTVFREFDPAAKQEEERALHEAKLAKMEAEMKSVFQQKVSEKEKKLQRSEADLFARHKEMKDKLTKQIKLLEEKKAQLEKQKLLPQDPPAQPAPQKSRKGFLR
What is the function of this protein?
Plays a role in the cell cycle.  Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.
What are the official names of this protein?
Cell division control protein 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Bud neck. Note=Present at the bud neck during cell division.
Protein: RRT5_DEBHA
Sequence: MSLVIPESPMFEVANNGKKSSRVYIKNLHFNTSEEELEVFLKKYEPRHRPFGIAYAEFSSVEQASKVVKDLNGALFKDRQIFVKLHVPFSPTGKPIFGRRKTSSGAEKLGDASNKVNLSAKTDKPLSSDTKDFDGVASTVPRSINIEDIPFTDEPKKVQDEDVQKKLSNDTIFIGNAVDKTVDKDVREFFKDYYPTQVFIFRGANQKRMQRTISLRQKTVSVLVTLKKEEDLSKAISELNSKKLNGRAVYLKAAHLSKIEEVVNAAKITAVPSKSPPTTATADDEAQEQKGNTTAETSTLLEMFKDTQKKIQGKYKETIEKQIRPSDTPLGEEEEEEEEGDETKQGVPNEEMIVA
What is the function of this protein?
May be involved in the modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 5.
What is the protein family that this protein belongs to?
Belongs to the RRT5 family.
Protein: WNT3B_MELGA
Sequence: SGSCEVKTCWWAQPDFRAIGDYLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGLFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-3b.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TRPA_JANMA
Sequence: MSRIQSTLAALAAKNKKGLIPFITAGDPAPELTVPLMHALVAGGADILELGVPFSDPMAEGPVIQRACERALASGVSMHDVLGFVSEFRKTNNSTPVVLMGYANPIERMGQTKFILAAKAAGVDGTIVVDYPPEECEEFAATLKENDMDPIFLLSPTSTEERIQQVAKFGSGFSYYVSLKGVTGAANIDTKEVAERIAAIRKYVKLPIGVGFGIRDAATAKAVAQVSDAVVIGSRIIQELENSPREQAVERVQTFIAGIRKALDE
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: LACD1_STRP8
Sequence: MTITANKRHYLEKVSHQGIISALAFDQRGALKQMMAAHQEGEATVTQIETLKVLVSEELTPYASSILLDPEYGLLATKVRANQTGLLLAYEKTGYDATTTSRLPDCLVEWSVKRLKAAGADAIKFLLYYDVDGDEQINLQKQAYIERIGSECTAEDIPFFLELLSYDERISDNNSAAYAKLKPHKVNGAMSVFSDKRFGVDVLKVEVPVNMAYVEGFTEGEVHYSQAEAIKAFQDQEAASHLPYIYLSAGVSAKLFQETLYFAAAAGAQFSGVLCGRATWAGSVPVYITKGEDEARKWLCTEGFQNIDELNRVLEETASPWTEKI
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase 1, D-tagatose-1,6-bisphosphate aldolase 1, Tagatose-bisphosphate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: STHA_PHOPR
Sequence: MTKNKKPTHFDAIIIGSGPGGEGAAMGLTKAGLNVAVIERENSVGGGCTHWGTIPSKALRHAVSRIIEYNQNPLYCKNNSSLHSTFSQILGHAQDVVNKQTRMRQGFYDRNKCSLIFGEASFIDAHTVRVKNADNSTDLYSADKFVIATGSRPYHPEGVDFDHSRVYDSDSILQLEHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRHRLLEFLDNEISDSLSYHLWNSGAMIRNGETFEKIEGTDDSIILHLESGKKMRADCLLYANGRTGNTDKLNLNKVGLTPDSRGQLAVNQNYCTDVDHVYAVGDVIGYPSLASAAYDQGRFVAQAITTGEAQGSLIDHIPTGIYTIPEISSVGKTEQQLTADKVPYEVGRSQFKHLARAQIAGTEVGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGDGNTIDYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPUCC_BACSU
Sequence: MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTESEIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGKEAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKNASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYSTDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQELNYEVDGKLKEPSVVAKEFLEKHHYFD
What is the function of this protein?
Member of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline.
What are the official names of this protein?
Glycine betaine/carnitine/choline-binding protein OpuCC, Osmoprotectant-binding protein.
What is the protein family that this protein belongs to?
Belongs to the OsmX family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: HEM3_CAMJJ
Sequence: MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTKELEESMLRKEAHLAVHSLKDVPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAKIGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDFDAIILAMAGIKRLNLDKQVNFVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQVPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELLKKAESMI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: 4CLL6_ARATH
Sequence: MAATHLHIPPNPKTQTSHQNPPFWFSSKTGIYTSKFPSLHLPVDPNLDAVSALFSHKHHGDTALIDSLTGFSISHTELQIMVQSMAAGIYHVLGVRQGDVVSLVLPNSVYFPMIFLSLISLGAIVTTMNPSSSLGEIKKQVSECSVGLAFTSTENVEKLSSLGVSVISVSESYDFDSIRIENPKFYSIMKESFGFVPKPLIKQDDVAAIMYSSGTTGASKGVLLTHRNLIASMELFVRFEASQYEYPGSSNVYLAALPLCHIYGLSLFVMGLLSLGSTIVVMKRFDASDVVNVIERFKITHFPVVPPMLMALTKKAKGVCGEVFKSLKQVSSGAAPLSRKFIEDFLQTLPHVDLIQGYGMTESTAVGTRGFNSEKLSRYSSVGLLAPNMQAKVVDWSSGSFLPPGNRGELWIQGPGVMKGYLNNPKATQMSIVEDSWLRTGDIAYFDEDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTAAPNEECGEIPVAFVVRRQETTLSEEDVISYVASQVAPYRKVRKVVMVNSIPKSPTGKILRKELKRILTNSVSSRL
What is the function of this protein?
Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors (PubMed:18267944).  Acts as a carboxylate--CoA ligase that can use preferentially p-coumarate, ferulate and caffeate as substrates and, with a lower efficiency, (E)-cinnamate and 4-hydroxybenzoate as substrates (PubMed:24838974).  Involved in the biosynthesis of ubiquinone from phenylalanine by activating the propyl side chain of 4-coumarate, and possibly trans-cinnamate and 4-hydroxybenzoate, for subsequent beta-oxidative shortening and the formation of the benzenoid moiety of ubiquinone (PubMed:24838974).  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity).
What are the official names of this protein?
4-coumarate--CoA ligase-like 6, 4-coumarate--CoA ligase, 4-coumarate--CoA ligase isoform 7, At4CL7, 4-hydroxybenzoate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: ENO_CLODI
Sequence: MGAEVFHSLKKVLGEKGLASGVGDEGGFAPNLGSNIRRAGYTAVISHRVAKYNQLLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis (By similarity).
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the bacterial cell surface (By similarity).
Protein: IFT74_CHLRE
Sequence: MDRPSSRGALALGAGGLGKAPTGGAVQQPDRPMTGQRGAAPAGPMRAPAGASIIGAGPPGTAMRGGPGPAGGPPGTAYKRMGTASQRPGTGQQAAAAAAAARAGQQLQVENRPITNHGVSGMKTAAAGVGRQVLDKNYFMNELRQKRMEIAQVTSNMKSDLEALERKQAQYNSMDKRASDLSKEVKILQEALADYNTVLDKVGSQAPVYVIQQEFAALKDRNEQQRKRVDEVLTERLNLESKAKQAESKMSEIQASMDQRLNSMPPSQRNEYTTLVAEQQQLQADSKRFEEVLDELDKALQASEGELARNPFKQRSLQLQEQIRALTEKKYELTEEERQSKRSPEELRADLMAKIKRDNTEVEQMTQQIRELQDQIKKMEERVKSLGGATSGAAAAEEKANREKFEELLAKERDLNNFMDGFPSRKAAKMQEKQQKEDGIVGVLEKMVKMQGIIGSNLPSQKKYKEMQDELEYKKMQLENTQTTQERLKEELTMRRTELEKIDTLEDKIKLELTQLAERQEAMEKEMGEFGSVEDIQRKANAARERMEGLRSVLLKRKDLLRSIVAERGLKFQAKRAQLQDHNLQVQLEKMEAKLKNLSAGVFEMDEFIKAKESETNYRQLASNIAALVDDLNVHVKKAVV
What is the function of this protein?
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium.  Binds beta-tubulin via its basic region.  Required for ciliogenesis.
What are the official names of this protein?
Intraflagellar transport protein 74, Intraflagellar transport protein 71, IFT-71, Intraflagellar transport protein 72, IFT74/72.
What is the protein family that this protein belongs to?
Belongs to the IFT74 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: MATK_ACEPM
Sequence: MKEYQIHLELDRSQQHNFLYPLLFREYIYTLAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNQFIGHNNQFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRAFRYWVKDASSLHLLRFFLHEYFNWNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGLLFERISFYGKVEDLVQVFVNDFQDNLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYINFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTMARFCNSLGHPISKPTWADSSDSYIIDRFMRICRKLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYLDIICINDFVNHDKFEIVPN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: USPC_SALTY
Sequence: MSYTHILVAVAVTPESHQLLAKAVSIARPVQAKVSLITLASDPELYNQFAAPMMEDLRAVMHEETENFLKMLGEKADYPIEQTFIASGELSQHILAVCRKHHVDLVICGNHNHSFFSRASCSAKSVVSASQVDVLLVPLAGD
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein C.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_BACC1
Sequence: MRLTPREIDKLLVVVAADLAYRRKERGLKLNYPESIAIITYEILEGARDGKNVAELMELGKNILSAEDVMDGIADMISDIQVEATFPDGTKLVTIHQPIH
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_BURCJ
Sequence: MKLFILAVGHKMPGWIASGFDEYTKRMPPELRIELREIKPELRSGGRSAESVMAAERQKIEAALPKGARLVALDERGRDWTTMQLAQALPGWQQDGRDVAFVIGGADGLDPELKARADVLLRISSMTLPHGMVRVLLAEQLYRAWSITQNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.