PharMolix/UniProtQA huggingface dataset:
Protein: LGUL_ECOLI
Sequence: MRLLHTMLRVGDLQRSIDFYTKVLGMKLLRTSENPEYKYSLAFVGYGPETEEAVIELTYNWGVDKYELGTAYGHIALSVDNAAEACEKIRQNGGNVTREAGPVKGGTTVIAFVEDPDGYKIELIEEKDAGRGLGN
What is the function of this protein?
Catalyzes the isomerization of the hemithioacetal formed spontaneously from methylglyoxal and glutathione, to S-lactoylglutathione, which is then hydrolyzed by a type II glyoxalase (GloB or GloC).  Is involved in methylglyoxal (MG) detoxification (PubMed:10913283) (Probable).  Involved in resistance to hypochlorous acid (HOCl), which is the active component of household bleach and a powerful antimicrobial during the innate immune response (PubMed:23536188).
What are the official names of this protein?
Lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: VSP_BOMIG
Sequence: MTGSKMLFACLALIAFLHPLVHVASAQECTTPNNKAGKCLGIRVCKPLLEMLQTQGHAAADFLRQSVCKYENNNPIVCCPNEESREDRGILVGNEYEPLRPPHCGFSNVSHTRVVGGKPAVLGAWPWIAALGFRYPRNPALEPLWKCGGSLISSRHVLTAAHCAEINELYVVRIGDLNLVRNDDGAHPVQIEIESKIIHPDYISGVTKHDIAILKLVEEVPFSEYVYPICLPVEDNLRNNNFERYYPFVAGWGSLAHHGPGSDDLMEVQVPVISNTECKNSYARFAAAHVTDTVLCAGYTQGGKDACQGDSGGPLMLPKKFTFYQIGVVSYGHKCAAAGYPGVYTRVTSYLDDFILPAMQ
What is the function of this protein?
Multifunctional venom serine protease.  In insects, it acts as an arthropod prophenoloxidase-activating factor, thereby triggering the phenoloxidase cascade.  When injected into larvae, it induces a lethal melanization response in target insects by modulating the innate immune response.  In mammals, it converts fibrinogen into fibrin, activates prothrombin, and also degrades fibrin.  In mammal, it may act in a cooperative manner with the serine protease inhibitor Bi-KTI (AC G3LH89) to promote the spread of bee venom under anti-bleeding conditions.
What are the official names of this protein?
Venom serine protease Bi-VSP, Thrombin-like enzyme.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. CLIP subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LAGE3_HUMAN
Sequence: MRDADADAGGGADGGDGRGGHSCRGGVDTAAAPAGGAPPAHAPGPGRDAASAARGSRMRPHIFTLSVPFPTPLEAEIAHGSLAPDAEPHQRVVGKDLTVSGRILVVRWKAEDCRLLRISVINFLDQLSLVVRTMQRFGPPVSR
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).  LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914).
What are the official names of this protein?
EKC/KEOPS complex subunit LAGE3, L antigen family member 3, Protein ESO-3, Protein ITBA2.
What is the protein family that this protein belongs to?
Belongs to the CTAG/PCC1 family.
Protein: PDXB_HYDCU
Sequence: MTPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEHTNVSFVGSTVVGLDHVDQPYLKENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSEKSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSDEFIDLDNALKSDIITVHTPLTKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNINPDLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSLTGNHQEDIHNVLQQCYRPEEDDAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPDPTFNNLLYSLGFQLI
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_METRJ
Sequence: MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGRSVMAEVVQNAVNEANRQIVTDNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVMPSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFTEREEGAEAQSGDRVTIDFVGRIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKDAEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLDALDGKYAFELPPSLVAQEFAAVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVRLGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVWDFYRKNAQALAELRAPLFEEKVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LLDD_ECOLC
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MRNC_LACLA
Sequence: MNKQQAELLNGIALAYIGDAIYEVFVREYLLDKGLTKPAMLQKNATKFVSAKAQAKIISAMDEVDFLTEYELTYFKRGRNAHSKTTAKNTDVVTYRISTGFEAVVGILHLTQQKERLQEFWDFSLKTIEADLV
What is the function of this protein?
Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor.  Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.
What are the official names of this protein?
Mini-ribonuclease 3, Mini-3, Mini-RNase 3, Mini-RNase III, Mini-III.
What is the protein family that this protein belongs to?
Belongs to the MrnC RNase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_CLOK1
Sequence: MSKPANNLQDIFLNGARKNRIPVIVYLTNGFQIRGIVKGFDNFTVILECDGKQMMVYKHALSTITPSKAILFNTPAGTDDRS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: ZNUC_HAES1
Sequence: MQIHSLKYPLIELKGVNVTFAQKTILSDINLTIYPNSIMTIVGPNGGGKSTLLKVLLKLLPATSGKVIYSKNVVIGYVPQNIYLDKSLPITVEKFLSLRKGTHKQDIKDALTLLSIGHLRLNAMQKLSGGEMQRVLLARAILNKPNLLVLDEPTQGVDITGQAELYQLIKQTQQQLNCAILMVSHDLHLVMADTNEVLCVNQHICCAGSPEAVSNDPVFIRFFGNQFAKNIAFYTHHHNHKHNIHGDICCGQDFRSTQCKHKIN
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LSPA_POLSJ
Sequence: MAKAFGKTSGSMLPWLGLALILLIADQFTKVLILGYYRLGDATYVTSFFNVVRVHNTGAAFSFLASASGWQRWFFTGLGIAAAVFIVWLLRSHAGQKLFSFALACILGGAVGNVIDRTLHGYVVDFLDFHYGNWHFPAFNIADSAITIGAIFLVLDELRRVRRS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GH_ALHV1
Sequence: MLFLILLCVTGAQAITTPAPPRPATTTPRRGVTSAPLIVPASSSELIVTLDGTFHSVTIDMTEIRQYVRQEIIEALWNASHVFESLETTYNRYKDVYRFTDQSIRVNTRGKLSTCKEVNKSTEVSFYKSITSQTINGKYDGDLGISNHQLGQQLFFYVMNVFPVENAFYPVRKHVVYSSLSLADGAYQLAGMATTNYVSLVVVRKISSTVTHEATIVFGNKKLLPSMRGSITKYDISLVNSDAEELLLLTSQKDYEYFSKNLFPQNWTDVFSLITSHTVGELAQILQTSVVDFARKGRCRSVHFNSHFLTTYLAVLSLYYKMGTEFVSKNERQISLQCILPKLYEANVCFDMVHRCFTSQYTRGFDSDGINRLSAAILGSMPFEPNQGLSVPTNWFLQTLYFVDGNLDPQNKGLHGITLILMDIYGRYVVNFTLTPEDRETLFYVYNALRGRKHLSTTMKNKYVSLIYCYTTSMCSATELAWGIEYWGEESTHSAHHSFSPCFMSLRFDYTLEKLNIEGSQDVKLTQTQLSNGVSAMYSLLTAKSSTWTIDSLSIKPCIYNASFVKMIVPFTNVSYVISQGVAAPGTTYDVAETFLKSSMVITVVSNSECYNLTASKEILKIPVVYNMTHPRIKCQLCDSVVISYDEYDGLQTMVYISNYKVQQDLFSDYSIFFDFNNMHTHYLLLMNNGTLFEIRGLYANRAMNIIIILLFTIAALAGVFIVYKIVMYMTFK
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: DUSTY_RAT
Sequence: MEADGQSWSGESVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAAAPLPAGQLSCISFPPMEEKYLQQIVDHLPCILILGQDCNAKCQLLNLLLAVRVLPTLKLDSDESCKLRRLRFTYGTRTQVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDTARVLADLEVTMHHALLQEVDIVVAPCHSHRPAVDVLSDLANDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPTLEIIRSSSGRADSERSPLSGQLMDLGYLSSSHRNCMASDQDCRAQSMLVEQSEKLRQLSTFSHQLLQTRLVDAAKALNAVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETVGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPSKRPLLGIVQPILRSIMDRLCKCDSERPSRGLDDST
What is the function of this protein?
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation.  Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death.  In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
What are the official names of this protein?
Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.
Protein: SYDND_ACAM1
Sequence: MRTHYCSELRNDHVGERVTLCGWVDRRRDHGGVIFLDVRDRTGLIQIVSDPERTPEAYPQADALRNEYVVRIHGEVSRRPDDSLNPRLPTGEVEIYADQIELLNAVHQQLPFQVSTADVESVKEELRLKYRYLDLRRDRMHQNIMMRHRLIQSIRRYLEDQQNFVDIETPVLTRSTPEGARDYLVPSRANPGEWFALPQSPQIFKQLLMVSGFDRYYQIARCFRDEDLRADRQPEFTQLDMEMSFMSQEEIIQLNEDLMRHVFKTLKDIDLPKTFPQMTYAEAMERFGTDRPDTRFDLELVNVSDLLEDSGFKVFSGAIKKGGQVKVLPIPDGNAKISNVRIKPGGDLFSEASAGGAKGLAYIRVKDDGAIDTIGAIKDNLSPEQTAELLERTGAKPGHLLLFGAGPTEIVNASLSRLRLALGAEMKLIDPDQIDLLWITEFPMFEWNADEKRLEALHHPFTAPYPEDEADLKTARAQAYDLVYNGLEIGGGSLRIYQADLQRRVFDAIGLSEEEAQDKFGFLLNAFNFGAPPHGGIAYGIDRLAMLLSGEESIRDTIAFPKTQQARCLLTQAPSSVDQKQLKELQIKSTAEPKN
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMA_SALPB
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGNTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVQVSGNLAGHSAEIEKLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNTLRAGLGYVHNKLSNMQPQIAMDRYLESMGQSADTSSFAADDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVSLDTATYVPIDNDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYKNGAHTSWDDNDDYEDCTQESGCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDPSSAPSDVPDYSDPGNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: ABL_FSVHY
Sequence: ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSPESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPAFAEIH
What are the official names of this protein?
Tyrosine-protein kinase transforming protein Abl, V-abl.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Protein: CLAB_PENCR
Sequence: MAALSFQCLCVASAVRAWERIESMVDVSFDVIIAASAQTIQLSQQSQQCQLHSQSSAAEAYNTFIRIYGRLVPLLERAITTYATNLQPPLSTSPTFQRTDPRNLTYPLDNQVLGSVLRDFSTHRSLQEQRNPATMVCRPSKMTLGQYEMDEQQSQYLALDVICRTLRNLVIVLQEMGGGENAEIRQVDARLLTILVQVRRLLENTSATLSILES
What is the function of this protein?
Part of the cla gene cluster that produces clavatol and ortho-quinone methide (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).  The function of claB has not been investigated yet (Probable).
What are the official names of this protein?
Clavatol biosynthesis cluster protein B.
Protein: RNPH_SHIFL
Sequence: MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACVALADALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAICDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: SPED_ECO27
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTTEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSDDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: FCK2_FUSPC
Sequence: MATLHAYFDPANYSLFFVLGVLTHVFIFRRGEWDLHVFNILQAFAVLESSLVYIVTRAVQAQGLSLWKVTTISSCFTLSTLMGLLISILMYRSWFHRLRRFPGPFCARLSNLYITFRAFKKNRLYEEVQQLHRRYGDIVRIGPNELSIIDPHALRALHSNSSPCTKGPWYSVEHPIKALQMTRDKEEHAYRRKAWDLAFSSKALREYEARVAGYTTQLVDQIEASQSTPIDASLWFNFYSFDVMGDLAFGRTFDMLKNGTAHPFMELVHSNMLTAGSLSHLPWIFPLLKRIPLLNQKTLEFQGWLKQQVDWRQKNNPDLPDVFSWILSDYDALDKPTAQDTINLRGDAQLIAVAGSDTTAASLSCLFSELAVNPETCLNLQRELDQYHAEHDKPDHLSLSKLRYLQACIDESMRLYPAIPSGLQRMTPPEGLDIGNTYLPGDTIVTIPTYTFNRDERLFTHADKFIPERWTTKKELTKDPSNFVPFSIGQYSCVGKQLGLMETRFVASQILVKYNVRLAHEDVARDFVAGLRDGFTLAMPSLSLVFTQRTT
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of cytokinins such as fusatin, fusatinic acids or 8-oxofusatin, known for their growth promoting and anti-senescence activities toward host plants (PubMed:28802024).  FCK1 is a bifunctional enzyme that performs the first steps in the biosynthesis of Fusarium cytokinins (PubMed:28802024).  It first condenses adenosine monophosphate (AMP) with dimethylallyl diphosphate (DMAPP) to yield isoprenyl adenosine monophosphate (PubMed:28802024).  It then catalyzes the removal of the phosphoribose to produce isopentenylaldehyde (PubMed:28802024).  The cytochrome P450 monooxygenase then converts isopentenylaldehyde to trans-zeatin (PubMed:28802024).  A condensation step converts trans-zeatin to fusatin which is further modified to produce fusatinic acid (PubMed:28802024).  The mechanism for oxidation of fusatin to fusatinic acid remains unknown (PubMed:28802024).  8-oxofusatin could be produced through several pathways, via direct oxygenation of fusatin, or via the 8-oxo-pentenyladenine intermediate which itself must arise from either the prenylation of 8-oxo-AMP by FCK1 and/or oxygenation of isopentenylaldehyde (PubMed:28802024).  Both the FCK3 and FCK4 enzymes act downstream of the identified cytokinins to produce yet unidentified compounds (PubMed:28802024).
What are the official names of this protein?
Cytochrome P450 monooxygenase FCK2, Cytokinin biosynthesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1674_METJA
Sequence: MLKVLISPLGVGDTNTDVYKRQYKTAEYKFEGDIDGIESPFVLSVLIEKLKVDKVIVVGTAKSMWEKLYEYYAKEVGEFDEEYWIEIGKKVGMSKYDNYALSEEDLKKIEKVIDKYLKKINPNAVGGSKCKIIKYGIDKDEIWENFDLFMSLINEVNDGDEIYLDITHSFRSIPLFMYVMLEFMRYFKNVKLKGIYYGMLDVIRELGHAPVVDLSPIFEISEWIRGMYEFTTYGNSYLISKLLENEDKEIAEKLQKISRYIDANYLKELREEVKTLKPLLNEKKDTGRFLKYFIPELHKFIDKLKYEDSDFEFQISMAKWNFDNKKYSSGYLCLTDSIFWKLCELYNLPSVYKNREVMKGIIYNPSLNKKYSAFGSIKDMHYKRLRNIRNKIAHADVSKKGDDFNPENDLEDVVNLLKNVNLPDFDKIIEDLLLDVKNNQNNKTLKLLKNILNIQIIRKIIKAYNFESNEIYWDFVSGYLLNKNNKCNNEKLREIIEIFHKNIEDAGELEEAFNFVKNTEDEELLDSLALQNAIMHYALFKLSNAYNIKNKEDKEAIKWVLLNQNLCSKHPILKEINNNYHKIFKNKDKPMSNEILEASKNIIRLLNSDLSEIKDSVPLNLIIIRYRSYKNNRR
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  The type III Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
What are the official names of this protein?
CRISPR-associated protein MJ1674.