PharMolix/UniProtQA huggingface dataset:
Protein: TTC16_HUMAN
Sequence: MTDSDEDALKVDQGPSRDIPKPWVIPAPKGILQHIFGTSHVFQSICDVKPKVTGLTVPLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLERLTFVLYLQGQCLFEQCAFLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQDAGILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSRQLLQNIFGARQDVATVLLLNPKQPKLSLLMTNLFPGMSVEEVLSTQIAHLARLQLEQMVEGSLQAGSPQGIVGMLKRHELERQKALALQHSWKQGEPLIATSEELKATPEIPQVKPGSSEGEAEAPEEEEEKEKEKKEEKKSELIPSKVASLSDSYLDQTSSASSMSFRTTGTSETEMSAICQEYRSTSATAVTFSDSSLLKTQSSDSGNNREALSHGPRKIKATQGQRQSLSKTEPTQSQRRNSSKTKATIHKRNSSKTKATQSQRRNSSKTRATQGQGQSSSKTEATQGQRQSSSEIEATQGPRQEPSKTKTTRSPRQRPRKVKAARGRSWRPSKVDATQGRSRGLLRSSTKTEAFYDSNWSLSKTEYAQGQGQRSSKAEGAQGKSQGMSSTSSKAESTWGPSPSLSKTEVDQDLTYYEAV
What are the official names of this protein?
Tetratricopeptide repeat protein 16, TPR repeat protein 16.
Protein: PEPT_STRPM
Sequence: MKYDNLLDRFIKYVKVNTRSDPDSETTPSTESQEAFALTILKPEMEAIGLQDVHYNPVNGYLIGTLPANNPTLTRKIGFIAHMDTADFNAENVNPQIIDNYQGGDITLGSSNYKLDPKAFPNLNNYIGQTLITTDGTTLLGADDKSGIAEIMTAIEFLTSQPQIEHCDIKVAFGPDEEIGVGADKFEVADFEVDFAYTMDGGPLGELQYETFSAAALEVTFLGRNVHPGTAKDQMINALELAIDFHEKLPAKERPEYTDGYQGFYHLTGLTGTVEEARASYIIRDFEEASFEARKVKVENIAQSMNAQLGTKRVLVELNDQYYNMKKVIEKDMTAIELAKEVMEELAIKPVIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEFVSLQTMERAVDVIIGLVCKA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_CALS8
Sequence: MPKVPVYNIEGQQIGEIELNDSIFNVPINTHVLHQAVVAHLANRRQGTFAAKTRAEVRGGGRKPWRQKGTGRARQGSIRAPTWRKGGVVFAKKPRDFSIDLPKKVRRLALKCALSSKVKENNLIVLDKWDMNQYRTKEVIRVLKNLGLENEKALIVIPEKNEYLQKSTKNIPEVKTLQVGNLNVFDILKYDKFIILQDAVKKVEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PMT1_NICAT
Sequence: MEVISTNTNGSTIFKNGAIPMNGYQNGTSKHQNGHQNGTSEHRNGHQNGISEHQNGHKNGTSEHQNGHQNGTSEQQNGTISHDNGNELQLLGSSNSIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPSIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPINPIDKETTQVKSKLAPLKFYNFDIHKAAFILPSFARSMIES
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (By similarity).  Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (By similarity).
What are the official names of this protein?
Putrescine N-methyltransferase 1, NaPMT1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family.
Protein: RS10_ACTPJ
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ARP8_ORYSJ
Sequence: MAVLLRKVWGSVLARAAAGAAPPEAFAAAASPRRPQAAGEYGSLGALDVLPIDVLAQILRLLGPADAARSTAVCRAWRLLASDNGLWAFFLRLGPDPWELVVFAETHLGAGPALHPGLYYDSSPQLSFKHVYTRRAVVPGSIIVDGGSGYCKYGWSKYAAPSGRCATFLEFGNIESPMYARLRHFLSTIYTRMQVKPSTQPIIVVLPLCHSDDTESARASRKQYRDTLYSVLFDMNVPAVCSVDQAVLALYAAKRTSGIVVNIGFNATSIVPIFQGRVMHEIGVETVGQGALKLTGFLKELMQQRNITFESLYTVRTIKEKLCYVAADYEAEKRKDTQASCEVDGEGWFTLSEERFKTAEILFQPQIGGVRAMGLHKAVSLCMDHCYNSEVFGDDNWYKTVVLSGGSSCLPGLSERLEKELRELLPAHISEGIRVIPPPFGTDSAWFGAKMISNVSTFTEAWCIKKKQFRQKTRRNGPSFVNVW
What are the official names of this protein?
Actin-related protein 8, F-box protein ARP8.
What is the protein family that this protein belongs to?
Belongs to the actin family. Plant ARP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.
Protein: RHM2_ARATH
Sequence: MDDTTYKPKNILITGAAGFIASHVANRLIRNYPDYKIVVLDKLDYCSDLKNLDPSFSSPNFKFVKGDIASDDLVNYLLITENIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFIHVSTDEVYGETDEDAAVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKMIPKFILLAMSGKPLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEIGHVYNVGTKRERRVIDVARDICKLFGKDPESSIQFVENRPFNDQRYFLDDQKLKKLGWQERTNWEDGLKKTMDWYTQNPEWWGDVSGALLPHPRMLMMPGGRLSDGSSEKKDVSSNTVQTFTVVTPKNGDSGDKASLKFLIYGKTGWLGGLLGKLCEKQGITYEYGKGRLEDRASLVADIRSIKPTHVFNAAGLTGRPNVDWCESHKPETIRVNVAGTLTLADVCRENDLLMMNFATGCIFEYDATHPEGSGIGFKEEDKPNFFGSFYSKTKAMVEELLREFDNVCTLRVRMPISSDLNNPRNFITKISRYNKVVDIPNSMTVLDELLPISIEMAKRNLRGIWNFTNPGVVSHNEILEMYKNYIEPGFKWSNFTVEEQAKVIVAARSNNEMDGSKLSKEFPEMLSIKESLLKYVFEPNKRT
What is the function of this protein?
Trifunctional enzyme involved in UDP-beta-L-rhamnose biosynthesis, a precursor of the primary cell wall components rhamnogalacturonan I (RG-I) and rhamnogalacturonan II (RG-II).  Catalyzes the dehydration of UDP-glucose to form UDP-4-dehydro-6-deoxy-D-glucose followed by the epimerization of the C3' and C5' positions of UDP-4-dehydro-6-deoxy-D-glucose to form UDP-4-keto-beta-L-rhamnose and the reduction of UDP-4-keto-beta-L-rhamnose to yield UDP-beta-L-rhamnose (PubMed:17190829).  Required for the normal seed coat epidermal development (PubMed:14671019).
What are the official names of this protein?
Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2, NDP-rhamnose synthase, Protein MUCILAGE-MODIFIED 4, Protein RHAMNOSE BIOSYNTHESIS 2, Rhamnose biosynthetic enzyme 2, AtRHM2, UDP-L-rhamnose synthase MUM4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the dTDP-4-dehydrorhamnose reductase family.
Protein: YP85_AZOBR
Sequence: MSDVGEIAADRLKSFVERIERLEEEKSGLQEDIKEVYSEAKGTGFDVKIIRQIIRLRKMDKADRQEQRAILEMYEEALGMTE
What are the official names of this protein?
UPF0335 protein pRhico085.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: LEC_SOYBN
Sequence: MATSKLKTQNVVVSLSLTLTLVLVLLTSKANSAETVSFSWNKFVPKQPNMILQGDAIVTSSGKLQLNKVDENGTPKPSSLGRALYSTPIHIWDKETGSVASFAASFNFTFYAPDTKRLADGLAFFLAPIDTKPQTHAGYLGLFNENESGDQVVAVEFDTFRNSWDPPNPHIGINVNSIRSIKTTSWDLANNKVAKVLITYDASTSLLVASLVYPSQRTSNILSDVVDLKTSLPEWVRIGFSAATGLDIPGESHDVLSWSFASNLPHASSNIDPLDLTSFVLHEAI
What is the function of this protein?
Binds GalNAc and galactose.
What are the official names of this protein?
Lectin, Agglutinin, SBA.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: TRK1_LYMST
Sequence: MRGPRRFRLWTRANVLTVISILTSILSGAGCSPLSQLPSDNPAHVGVQDGVTTERVDRSKNHRNTTASSGAHRVTSGEPLGDRVTTRSTTAPDQVPGDASRNTTMAGTKCSLQVDLSTFACPADCQCNATSEGMVVSCVTPDTLREFPVIAREVARAVIKLELRGQSKLTSLKTELKFFTCLKHLTIENCGLNNIQGIAFKTLTSLETINLRHNHLTEFPQELLRTLNLRELWLEGNALTCSCTNLWLRSVDVAADRSEMTCSTRDGVSKMKMTQFKCEPCGIPDIRNMTLVFEPKNGMFLLRFVISGCPKPKIDLLRNHHHVLRSGSSQFKLTDFKSEFNGQVVTGTITILPHMETSQTTYVLTAVNSKGQANQTFHLYDQTTPASSIHIPLSNIPPRISSATTPRASPTEDFGPQTQVILPVVGVVILLISAVFIIYLCQRAKHRSHARQRCKKALLDKKFNEFQEGVPLTGLQLVDNPNYNLTKKKHVATTCPKTVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEGQLTREQLMKIVLQIASAMEYLALQHFVHRDLATRNCLVGCDLVVKLGDFGMSRDVYTTDYYRVEGTAMLPVRWMPPESIIYRTFTTESDVWSFGVTLWEVFTYGKQPWFEYSNSEVIEHIKNSRTLKRPPRTCTDGVYRVMQGCWKPNPQDRLTMKDIAELLREEVSGDPVYIDIIA
What is the function of this protein?
May bind an endogenous invertebrate neurotrophin.  Binds human NT-3, but not NGF or BDNF.
What are the official names of this protein?
Putative neurotrophin receptor LTRK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: KGUA_NITHX
Sequence: MAAHGQGFDGVERRGLMFVLSSPSGAGKTTLSRLLIERVEGLSLSVSATTRPMRPGEVDGRDYRFVDKATFAVMVKCDELLEWATVFDNRYGTPRAPVEAALSSGRDVLFDIDWQGTQQLREKARADVVSVFILPPSATDLERRLHTRAQDSDEVIRGRMDRAAHELSHWAEYDYIVINQDIDEAFAEVQSILKAERLKRERRTGLTAFVRELQRQLEN
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_SALTY
Sequence: MSKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPRYTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGDEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_CARHZ
Sequence: MRTTYMAKPNEVERKWYVIDAAGKPLGRVASEAAKLLRGKHKPEFTPHVDTGDFVIIINAEKAVLTGKKLEKKMFYRHSRYPGGLKAIPYGILMKTNPVLAFEKAVKGMLPHNRLGRKLFKKLKVYAGESHPHQAQKPEIWQF
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y2194_DEIGD
Sequence: MAGHSKWAQIKRKKGANDKKRSAIYSKHIRAIQAAVRSGGSGDPAANLALKNAIAAAKADTVPADNIENAIKRAVGAAEGAADYKEVTYEGYGPGGTAIFIEALTDNVNRTVADIRAVFNKRGGSLGNSGSVAWQFEKKGVILLSDTSEAAQEVAIENGAEDIQESVDGLEISTAPNDLYAVQDALSAAGFKPESGQITMIPSNTVAVNGDDARKLMALVDALEDLDDVQNVYTNADLPEEVEA
What are the official names of this protein?
Probable transcriptional regulatory protein Dgeo_2194.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_RICRO
Sequence: MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFFNSLVEYITSGAVVLQVLKGEDAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIEFFFNKSEIIE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIPT3_DANRE
Sequence: MNESVAKKTQETLGKVIKKPPLTEKLLSKPPFRYLHDIFSEVIRTTGFMKGLYVEAEMKSDNVKDKDSKIAFLQKAIDVVMLVSGEPLAAKPARIVAGHEPEKTNELLQVIAKCCLNKLSSDEAVKRVLAGDKLDQKGKPSTSRSQDKENREGREHHRDREERKGIKESSGSREQKDPDQPKDQESKRDDKDRRRDAERSDKGRERERTKDRDRDKDKSRDREKDKTREKEREREKDRNREKERERDKDRDKKKERESHKDRERDKDREREKRREKEKDKERPRETEEKLKDRGDRKIKAAEEISKSKPQPEVASRTHQAETEEAESPSRIPRPSSAKGQRRKPKTGGQGTEQDETESEGEAEGPSAEKPIPLENGDVTDPAALQTTHSRRLPRPSSARPAAPRVKRQESYTDATPAERLGSGKTPASVILDGKKLSEDEDDEDGQFVVEEAAPPPSDVPEVESNSLELQGDDKHGGLVKKILETKKDYESSPSSKSKEQDRSLVSEASRKKERELVAREIERLRSSIQTVCRSALPLGKIMDYIQEDMDSMQNELQSWRKENKENAQALLQEQRITDGVVEPLKVELAELEQLIKDQQDKICAVKSNILKNEEKIQKMVSSISFSSQT
What is the function of this protein?
Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules.  Involved in the regulation of microtubule cytoskeleton organization.  Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268).  Involved in ciliogenesis (By similarity).
What are the official names of this protein?
TRAF3-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAF3IP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip.
Protein: PGFRB_TAKRU
Sequence: MLRASAMRAAVLHLTVALAALLSSCTTVSCLKIVPEEKQLILAEGSSLSLTCAGSSETTWDLKSDDVPFFQMKAESSDLNYKIVQSNSTASVLTLWHVDWKNTAVYQCREQLTGEIKEVAVFVPDRFSPQTLRFIESSHGMVTKTSGESTVPCVVTNPNITVTLYDKDTDLPVNGVYVPSEGFKAYLDYRTYVCRGELNGEVKESQAFNVYSIHVPEDIDAYVNASQTVLKQGEPLTVNCTVQGVELVLFSWDIPNRDIVKHKPETVVLSATTMRSCLVFPHATVAHSGTYVCHAHESTQDQKAFASVNITVLERGFVAVKSTRKQNITAELQENVELRVEIEAYPPPQIRWKKDGAPVRGDKTIIIRQEHEIRYVTILTLVRVRTEQKGLYTALITNEDDVKEVTFALEVQVLARIKDLTDHHLPGKKQLVTCVAEGVPTPTIQWYSCDSMLKCNNQTSLWQQLKADPELLSIHTSVTEARQTNQVRSQVTFFKPQHTTVRCETTNQEGLIDFRDVKLVSSSLFSQVVLLAVVLTLVPIIIMSIIILIAVWKKKPRYEIRWKVIESVSQDGHEYIYVDPIHLPYDLAWEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHSQSSIKVAVKMLKATARRSETQALMSELKIMSHLGPHLNIVNLLAACTKHGPLYLVTEYCRYGDLVDYLHRNKHTFLQYYLDKNQDDGSLISGGSTPLSQRKGYVSFGSESDGGYMDMSKDEPAVYVPMQEQMDTIKYADIQPSPYESPYQQDLYQEQGGGRVDLVISDSPALTYDDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSPLKRGYRMAKPAHASDEVYEIMKRCWDETFEKRPDFSFLVHCVGDMLTDSYKKKYSQVNETFLKSDHPAVARTKPRLSSPFPIANPAFGSPSLVGLSDFPDPYNQNTRRFRNEAEVQEGVTSFNEYIIPIPDPKPEKS
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration.  Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.  Required for normal development of the cardiovascular system.  Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli.  Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles.  Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB.  Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity).
What are the official names of this protein?
Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Protein: OAZ_DROVI
Sequence: SDVPVHHRTDHDRASLLTGSSRKSSVDSAGGSLFEASSRASSPSSSSSSECSDTESHDIHSLCSEDDCQEVLRQILQHDQPVHISIKLHVTEDQSTNWMSILNPNNNILYVAFPTDFAPAGSKETFTSLL
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
What are the official names of this protein?
Ornithine decarboxylase antizyme, ODC-Az, Protein gutfeeling.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: FTMG_NEOFI
Sequence: METFDAIQLPYPGVVGASLLVILGIILLFPLDTGHFISINQHPWDFFQTKAKQEFEYNAAALLNEGLQTGRSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDPVLLVDLPGLETMFQGSLHNQVPPMAVRALNKELVHLTPFLSEEAMNCLQTRWTDSAEWHDVSIPETVLALIAQMTTRALLGPALCRNPEWLDIAKSFTTNRAIAVAAVQSWPSFLQPVIHWFLSPCRALRRQIQCARNILLPVLERERRSYRSDQPTKREFSNLAFIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIQPLREEVVSVVGKNGLHSHSLRKLTLMESVMKETQRLEPAVIIGMFRLAKEKVTLKDGTVIPKGTNIAFANDLRFDPEMYPEPETFDGYRFQRMREDPEKIDLTPFTKTRMSHLAFGHGKHACPGRFLACDEAKLILCHILLKYEIRAVEGSPPELRARGMFVQLDPGAMMSVRRRRENEFALHG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:23109474).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmPS/ftmA (By similarity).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (By similarity).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (By similarity).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (By similarity).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (By similarity).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (By similarity).  Finally, verruculogen is further converted to fumitremorgin A by the verruculogen prenyltransferase ftmPT3 (PubMed:23109474).
What are the official names of this protein?
Fumitremorgin C monooxygenase, Fumitremorgin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PEX1_YEAST
Sequence: MTTTKRLKFENLRIQFSNAIVGNFLRLPHSIINVLESTNYAIQEFGIAVHSHNSDIPIVHLGWDGHDSGSSENVVLINPVLATVYDLNQKSPLVDLYIQRYDHTHLATEVYVTPETSDDWEIIDANAMRFQNGEILHQTRIVTPGETLICYLEGIVTKFKIDRVEPSMKSARITDGSLVVVAPKVNKTRLVKAEYGHSNKTILKNGAIQLLKKVILRSTVCKMDFPKDNLFVVYISDGAQLPSQKGYASIVKCSLRQSKKSDSDNKSVGIPSKKIGVFIKCDSQIPENHIALSSHLWDAFFTHPMNGAKIKLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIEIKKGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIERHLPKHYHVKETGEVSRTSKDEDDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDHHIFVKYADCETLHETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNGQWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKHARAKLLEYFFSKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELFSKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWLSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASELTAVVTINDLLEACQETKPSISTSELVKLRGIYDRFQKDRNGEMPNGENSIDIGSRLSLM
What is the function of this protein?
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:15634331, PubMed:16007078, PubMed:16911527, PubMed:26170309, PubMed:26066397, PubMed:29321502).  Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:26170309, PubMed:26066397, PubMed:29321502).  Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29321502).
What are the official names of this protein?
Peroxisomal ATPase PEX1, Peroxin-1, Peroxisomal assembly protein 1, Peroxisome biogenesis protein PAS1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Shuttles between the cytoplasm and the peroxisomal membrane.
Protein: WHB7B_MYCTO
Sequence: MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVSCPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA
What is the function of this protein?
Acts as a transcriptional regulator.  Probably redox-responsive.  The apo- but not holo-form probably binds DNA (By similarity).
What are the official names of this protein?
Probable transcriptional regulator WhiB7.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_CLOBJ
Sequence: MAGDKKFVEDITPMDEDFAQWYTDIVKKAELADYSSIRGCMIIRPNGYAIWENIQKYVDTKLKEYGHENVSMPIFIPENLLQKEKDHVEGFAPEVAWVTHGGDDELAERLCVRPTSETLFCEHYAKIVQSYKDLPKLYNQWCSVVRWEKTTRPFLRTTEFLWQEGHTIHETKEEAESHSLKILNMYSRLCEDMLAMPVVMGKKTDKEKFAGADDTYTIESLMHDGKALQAGTSHYLGQNFSKAFAIQFSDRNGKLDYPHYTTWAVTTRLIGAIIMVHGDNSGLKLPPRIAPTQAVIIPVAQHKEGVLEKAKELKEKLAKVVRVKLDDSDKMPGWKYSEYEMKGIPLRIEIGPKDIEKNQAVLVRRDNREKTIVSLDEIEIKVQEMLDIIHNSMLEEAKKTRDEKTYVATNMEEFEDTIENKPGFIKAMWCGDRACEDKIREVTGATSRCMPFEQEVVSDTCVCCGKKAKNLVYWGRAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.