PharMolix/UniProtQA huggingface dataset:
Protein: SECA_AZOSB
Sequence: MISGLLKKLFGSRNDRLIRQYSQNVRKINALEPEIAALSDEALRGKTGEFRQRLADGATLNDLLPEAFAVVREAGKRVHGMRHFDVQLIGGMVLHDGKIAEMRTGEGKTLVATLAAYLNALPGKGVHVITVNDYLASRDAEMMGRIYGFLGLTTGCNLSRMGHAEKQLAYAADITYGTNNEFGFDYLRDNMVYATGERVQRGLNFAVVDEVDSILIDEARTPLIISGQAEDHTDLYLKMNQVAPLLKRQEGGLDDKDSVIEPGDYTVDLKAHQVLLTEQGHENAEQILVRIGLLPEGAGLYEPGNILLVHHLYAALRAHALYHKDQHYVVQNGEVVIVDEFTGRLMAGRRWSDGLHQAVEAKEGVRIQAENQTLASITFQNYFRMYGKLAGMTGTADTEAFEFHHIYGLETVVIPTNRPMVRKDENDKVYRTAKEKWEAVIADIADCVKRGQPVLVGTTSIETNEYLSGLLNKAKIAHQLLNAKQHDSEAQIVAQAGRPGVVTIATNMAGRGTDIVLGGNIEKPVSQVRDDDSVPAAEKESRIAALREEWRKVHEQVIAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLEDPLMKIFAGERLNAIMVRLKMPEGEAIEHGMVTRSLESAQRKVEQRNFDIRKQLLEYDDVANDQRKVIYQQRNELLETEDISETIQAMRQGVLHDLFRTYVPVDSVEDQWDIAGLEQALASDYLLKLPLLEWVKAEPNLDDEAILKRIIDAGEEAYAAKIAQVDAAAWHQFERNVMLQSLDTHWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFETLLDTVRADVSKLLMTVQIRTEAQLDEAEAPPEMENVQYHHADYDEALAAAAASTAETPVQGGPKVGRNDPCPCGSGKKYKHCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PURL_PROMP
Sequence: MIDSSSNNTYDVNESLKVENLTRDDYEEICKRLGRKPNRTELGMFGVMWSEHCCYRNSKPLLANFPTTGKNVLVGPGENAGVIDVGNDQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKLSNISLLRGVVSGISHYGNCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETDEIVCSGAKEVGSPVLYVGNTTGKDGVGGASFASSELNTNSLDNRPAVQVGDPFIEKSLIEACLDAFKTGDVLSAQDMGAAGLTCSSAEMAANGSLGISINLDLVPARENDMSAYQYLLSESQERMLLVVKEEKLNTLINQFKKWGLFANVIGEVISRKEVIISQKNQIVAQIPTSALSDETPINIHNIIKEPPIHLLEKWEWTEEELPAISENKILSLKDQQKYSFSEIILKLLSNPSIASKSWVYRQYDSQVQSNTVFKPGDADAALIRLRRQDEKNKNNEFSGVAASVDCNSRWVLLDPYRGSIAAVAESARNVSCVGAQPIAITNNLNFSSPETEIGYWQLSSACDGISKACIALETPVTGGNVSLYNESKNQNNQVTPINPTPVIGMVGTIKNVDKAISSGWKNINDQIWIIGSNASESSIAASSYLEYFHDLVTGRPPKIHLQDEKYCQSFLRDSIQKNYIASSHDVSDGGLAVALSECCILSSKGAYIQLEEKNARQDNLLFSEGGSRILFSVNKKEEQNFLNFLEIKSKDFGRNVYVKKIGFVSEHNLDITLQDQTLCNLRVDELTEKFNNSISNCF
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_ANADE
Sequence: MAETQTTTPKKKAERRAPPPARARKNRPAAPAPGPHASLSYLRVAPRKVRIVADEVRGMKVGDALAMLKYTPQSAAKPLAKLLRSAVANAEQGGGRVDVDALFVKTLTVDQGPKMRRFMARAMGRAFRVEKKTSHVYVELGTAARG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RIMP_ANADE
Sequence: MTGIGEQSIAEQVRSLLEPVLERDGYELVEVEWARLAGRWTLRVFIDKAGGVGIDDCQAVSKTVEPILDVADFIEPAYDLEVSSPGLDRPLRKPRDFDRYAGQRVHVKAYGPVAGTAPGSPARKHWTGVLKGFRDGAVELDVDGALHRVPHDQIAKANLEYDVEGDLRRKD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_ECO57
Sequence: MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFAEQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIB_RAT
Sequence: MLALEAAQLDGPHLSCLQYPEGVFYDLDSCKSFSYPDSDGGPDSTWGWTEAPPAPAIAAYEAFDPAATAAFAHTQAVQLCYGHGPSPSTYSPVGTLDPAPSLEASGPGLQVYPSEDFTSQTLGSLAYAPYPSPVLSEEEDILLDSPALEVSDSESDEALLAGSEGRGSEAGARKKLRLYQFLLELLLRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAARRA
What is the function of this protein?
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer.  Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells.  These cells have the capacity to produce large amounts of interferon and block viral replication.  Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation (By similarity).
What are the official names of this protein?
Transcription factor Spi-B.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LDHA_FUNHE
Sequence: MSTQEKLISHVMKEEPVGCRNKVTVVGVGMVGMASAISVLLKDLCDELALVDVMEDKLKGEAMDLQHGALFLKTHKIVADKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILLVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHLMGEKFHLHPSSCHGWIVGEHGDSSVAVWSGVNIAGVSLQTLNPNMGADGDSENWKELHKKVVDGAYEVIKLKGYTSWAIGMSVADLVESIVKNLHKVHPVSTLVQGMHGVKDEVFLSIPCVLGNSGLTDVIHMTLKPEEEKQLVKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A, LDH-M.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_STAA2
Sequence: MTIPEKPQGVIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGVDKHLAVIEDERRLMGRVLEGGFIDIPYLTDHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKNDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQVEDSSRPNVNISIIYFEDVSTETILDNNEYRSVNQLETMQNGNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: CLPP_STAA1
Sequence: MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I80AD
Sequence: MSLLTEVETHTRSGWECRCNDSSDPLVIAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYQQEKQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: DYL2_SCHMA
Sequence: MGERKAVIKNADMHEDMQETAVHTAAAALDKYEIEKDVAAYIKKEFDRKYNPNWHCIVGKHFGSYVTHETQHFIYFYLQERAFLLFKSG
What is the function of this protein?
Acts as a non-catalytic accessory component of a dynein complex.
What are the official names of this protein?
Probable dynein light chain, T-cell-stimulating antigen SM10.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y456_TREPA
Sequence: MNTRLALVLCAVGSGVLSFSCARTAEPTPAASTHVPVTTAGALSVTPPSSTDRWYQFSRTDGRVHLRACPAPSQPSAPEHFVPWTEAVRLSAVDAQQELLLINRAGVLPATQLARMQTAPVPRKAPSTPAAETTSLTLTPPALLATQSAEGFYSEPIPNSSPHPCQGTGAVFVRLYTDPLFTTSPQDSAAPFLVRYDVRTARWTSVAYTRALGLPRNAQCTALTHTRGTWYASFKSSEAERVSFAYFSFPSLSSLENLGPTQRREHPIGGKVQVPRPISAAAFRAACTPQRLHLPTASTSSDHHSDLHELLVHRLLARVPLSPLYLSARSPCWASDRSFLKTAHRTADERAHHANALIFHPPRARLSAALLTDSGHLYFVREDGSEGHARLSALPPQFVYTSFTLSGPSLIAGWEEQDFFQVGSTGLLCTEVESLTGT
What are the official names of this protein?
Uncharacterized lipoprotein TP_0456.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RBL1B_METPP
Sequence: MNEPTQITDTKKRYAAGVLKYAQMGYWNGDYVPKDTDILALFRITPQDGVDPIEAAAAVAGESSTATWTVVWTDRLTACDMYRAKAYKVEPVPNNPGQYFCYVAYDLSLFEEGSIANVTASIIGNVFSFKPLKAARLEDMKFPVSYVKTFAGPPTGIVVERERLDKFGRPLLGATTKPKLGLSGRNYGRVVYEGLKGGLDFMKDDENINSQPFMHWRDRFLFVMDAVNKASAATGEVKGSYLNVTAGTMEEMYRRAEFAKELGSVIIMIDLVVGYTAIQSMSNWARQNDMVLHMHRAGHGTYTRQKNHGVSFRVIAKWLRMAGVDHLHTGTAVGKLEGDPLTVQGYYNVCRDTHTKVDLPRGIFFDQDWGALKKVMPVASGGIHAGQMHQLIDLFGDDVVLQFGGGTIGHPQGIQAGATANRVALEAMVLARNEGRDIKNEGPQILRDAAKSCTPLAAALDTWGDITFNYTSTDTSDYVPTPSVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain 2, RuBisCO large subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: VP33B_DANRE
Sequence: MAQTERRDAPELPDFSLLKRLARDQLIFLLEQLPGKKDLFIDADLMSPLDRIANVTILKQHEVDKLYKVELKPIVSSSDQLCFLIRPRIQTVKWISDLVNSDKVAGRFRRYKIIFTPQKFYACETVLEEQGVYGDVTTDEWNFYILPLDDDILSLELPEFFRDNFLEGDQRWVTTGGGALHLLQSVYGSFSKVYGIGRCAKMVYESWRELMEEGEQRTRQPEFAKVFLIDRDVDFVTPLCSQVVYEGLVDDIFRIKCSSVEFGPDVTSSDKSIKVMLNSQDKVFNEIRNEHFSNVFGFLSQKAKNLQTAYDKRRGMDIQQMKAFVADELKGLKQEHRLLSLHIGASESIMKKKTKQDFQELLKTEHSLLEGFEIRECIAYIEEHINRQVSMIDSLRLLCLLSITENGLLSKDYRSLKAQYLQSYGIEHLLTFANLRQLGLLEEQQTGETLTVMESKVGKLVNDKTAGKLTDAFSSLAKKSNFRALSKRLALVPKSGEEYDLRVPRDMAYIFSGAYIPLSCKLIEQVLERDGWTGLEEVTRMLNGQDFAVTGGSSSSEARNKSNGQRIILVMFLGGCTYSEISALRFLGKERGCRFIVLTTAITNSGRLLEALLDKHV
What is the function of this protein?
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.  Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (By similarity).  Mediates phagolysosomal fusion in macrophages.  Proposed to be involved in endosomal maturation implicating vipas39.  In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (By similarity).  Plays a role in bile duct development.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 33B.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Protein: DXS_CAMFF
Sequence: MDIKSKSLEELTDLCDTLRDKILKTVSSNGGHLSSNMGAVELSVAMHYVFDVSKDPFIFDVSHQSYAHKLLTDRWNRFDSLRQFNGISGYTKPSESKFDYFVAGHSSTSISLVVGACKAIKLKGENRLPVAVIGDGAMSAGMAYEALNELGDRKYPCVIILNDNEMSISKPIGALSKYLSQMMAGQFYQKFKARVNQFLSYVPDSAAYMAKRFEEGFRLITPGMFFEELGLEYIGPVDGHDLKELISTFTTAKLMNKPVIVHIQTIKGKGYELAEGPKEKWHGVSPFNLKNGQSVNQANQKSATNIFSELLLNLAKKYENVVGVTAAMPSGTGLNKIIEVFPDRFWDVAIAEQHAVTSMAAMAKEGFKPYIAIYSTFMQRAYDQVIHDCAIMRLPVVFCMDRAGIVGEDGETHQGAFDISFLNAIPNLNLVAPRDEESFKNIMEFSYAFDSPLAIRYPRGNFILNNEYKSQKTALAKGEILENGDGSVAFIGYGNGVGKAVQTAKKLNFKPTIVDLVFAKPLDKELLLQIAKTHNKWYVFSDSAKRGGIGEILAGFLQENLLTNILIKSFEYEDTFIKHGKTSVVEDYLSISAEKISNTF
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: ENO_SHESR
Sequence: MAKIINVIGREIMDSRGNPTVEAEVHLEGGFIGMAAAPSGASTGSREALELRDGDKSRYLGKGVLTAVANVNGPIRAALIGKDATAQAELDQIMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGMPLYAHIAELNGTPGQYAMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKNFREALRMGAEIFHTLKKVLHGKGLSTSVGDEGGFAPNLSSNADALAVIKEAVELAGYKLGTDVTLALDCAASEFYKDGKYDLSGEGKVFDSNGFSDFLKSLTEQYPIVSIEDGLDESDWDGWAYQTKIMGDKIQLVGDDLFVTNTKILTRGIENGIANSILIKFNQIGSLTETLAAIRMAKAAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSLCRSDRVAKYNQLLRIEEQLGEKAPYRGLKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: YBJL_ECOLC
Sequence: MNINVAELLNGNYILLLFVVLALGLCLGKLRLGSIQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGMESRQLSLALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEVVVKNHNAVGKRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFVIGLMIGMITFQFSTFSFGMGNAAGLLFAGIMLGFMRANHPTFGYIPQGALSMVKEFGLMVFMAGVGLSAGSGINNGLGAIGGQMLIAGLIVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTIIVMVWPGLG
What are the official names of this protein?
Putative transport protein YbjL.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VATA_MOUSE
Sequence: MDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRNRGSVTYIAPPGNYDASDVVLELEFEGVKEKFSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED
What is the function of this protein?
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:23863464).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).  May play a role in neurite development and synaptic connectivity (By similarity).
What are the official names of this protein?
V-type proton ATPase catalytic subunit A, V-ATPase subunit A, V-ATPase 69 kDa subunit, Vacuolar proton pump subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Lysosome. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines.
Protein: ATPD_SODGM
Sequence: MSELVTVARPYAKAAFDFAVEHQAVAHWQAMLTFCAEVSRNERIAELLSGAVVPEKLAETFIAVCGEELDAAGQNLIRVMAENGRLTVLPDVLEQFTLWRAAQEATVEVDVISASTLKEEQLAKISAAMEQRLSRKVKLNCKIDKSVVAGVVIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: XENG_XENSI
Sequence: MASTGLPQLPPSQKAVIQSEKTPGAFEVSENRPVPVPKANELIVKVSAVSLNHCDWKMPGRVPCPGAVDGADYSGTIVRMGEIAALKSGFQIGDRVAGAQMASSRRRPWAGAFTEYLRDEYDMVWKVPDNLSWEQAAAIGCATTSTVGMALWISMKLPGTPENPIKEPKLVLVYGGSTASGTFAIQLLKLSGYKVVTTCSPKNFKLVEEYGADKAFDYHSATCGEDIRAYTNNTLEYALDIITEARTIRHCYAAIGRGGGRYCGFELLPEDLIATMRKSVKAEWVMGLEMTGLEIDLPGGYYRKANPELHTWFCDWKERYVALFGSGKTKTHPITVRQGGLEKVIDGIESMRRREVSGEKIVYPLYIKGC
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of xenoacremones such as xenoacremone A, a compound that shows inhibitory activity toward the PI3K/AKT signaling pathway and which has the ability to induce apoptosis of A549 lung cancer cells (PubMed:34900544).  Within the pathway, cooperation of the hybrid PKS-NRPS xenE and the trans-acting enoyl reductase xenG is responsible for the formation of the reduced tyrosine-nonaketide derivative (PubMed:34900544).  The alpha/beta hydrolase xenA then accelerates intramolecular nucleophilic attack to give a pyrrolidone derivative (PubMed:34900544).  Subsequently, three enzymes, xenF, xenD, and xenC, coordinately participate in the conversion to xenoacremone B (PubMed:34900544).  XenF catalyzes sigmatropic rearrangement to form an A-ring, which leads to an unusual intermediate with a hexane ring, which is required for the formation of the tricarbocyclic product (PubMed:34900544).  Epoxidation catalyzed by xenD and the formation of the paracyclophane ether catalyzed by xenC initiate a spontaneous intramolecular Diels-Alder (IMDA) reaction to yield xenoacremone B (PubMed:34900544).  Spontaneous hydration of xenoacremone B leads to the formation of xenoacremone A, which undergoes subsequent methylation to afford xenoacremone C (PubMed:34900544).
What are the official names of this protein?
Trans-enoyl reductase xenG, Xenoacremones biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: ALL2_CARMA
Sequence: EAYAFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Carcinustatin-2.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.