PharMolix/UniProtQA huggingface dataset:
Protein: NALP5_BOVIN
Sequence: MREAKIAPLSNYGLQWCFEQLGKEEFQTFKALLKEHASESAACSFPLVQVDRADAESLASLLHEHCRASLAWKTSTDIFEKMSLSALSEMARDEMKKYLLAEISEDSAPTKTDQGPSMKEVPGPREDPQDSRDYRIHVMTTFSTRLDTPQRFEEFASECPDAHALSGAFNPDPSGGFRPLTVVLHGPPGVGKSSLARRLLLFWAQGDLYKGLFSYVFLLRARDLQGSRETSFAELISKEWPDAPVPVEKVLSQPERLLIVVDGLEELELTFRDQDSSLLADWAERQPAPVLAHSLLKKVLLPECALLLTVQDAGLQRLQALLRSPRYLWVGGLSVENRMQLLLGGGKHCRRKTCAWHAGADHQEVLDKCQVPVVCALVREALELQGEPGKGLPVPGHTLTGLYATFVFQRLAPKDAGWRALSGEERGALKGLCRLAADGVWNAKFVFDGDDLGVHGLQGPELSALQQASILLPDGHCGRGHAFSHLSLQEFFAALFYVLRGVEGDGEGYPLFPQSTKSLTELRHIDLNVQLVQMKRFLFGLVSKEVMRALETLLGCPVRPVAKQQLLHWICLVGQHPAAAASPDLLEAFYCLFEAQDDEFVRLALNGFQEVWLQLNRPMDLTVSSFCLRRCQHLRKVRLDVRGTPKDEFAEAWSGAPQGLKIKTLDEHWEDLCSVLSTHPNLRQLDLSGSVLSKEAMKTLCVKLRQPACKIQNLIFKGARVTPGLRHLWMTLIINRNITRLDLTGCRLREEDVQTACEALRHPQCALESLRLDRCGLTPASCREISQVLATSGSLKSLSLTGNKVADQGVKSLCDALKVTPCTLQKLILGSCGLTAATCQDLASALIENQGLTHLSLSGDELGSKGMSLLCRAVKLSSCGLQKLALNACSLDVAGCGFLAFALMGNRHLTHLSLSMNPLEDPGMNLLCEVMMEPSCPLRDLDLVNCRLTASCCKSLSNVITRSPRLRSLDLAANALGDEGIAALCEGLKQKNTLTRLGLEACGLTSEGCKALSAALTCSRHLASLNLMRNDLGPRGMTTLCSAFMHPTSNLQTIGLWKEQYPARVRRLLEQVQRLKPHVVISDAWYTEEEEDGPCWRI
What is the function of this protein?
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity).  Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).  Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity).  Required for cortical actin clearance prior to oocyte exocytosis (By similarity).  Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER cellular localization (By similarity).  May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Cytoplasm. Golgi apparatus.
Protein: HOA_BURP1
Sequence: MILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGNGLGGSSCLLGQTPIGDRLMLETARAALRTSRLGVHFIPGLGKAADISLALEIGVDVVRVATHCTEANVSARFIEQTRAAGRTAFGVLMMSHMAPPDALLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLVDGLDIDVGFHAHNNLGLAVANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMEREGHDTRTTFERVMTLARGTETFLNPKTPHIQPANIASGLYGLFSGYVPHIQKAAQEFGVNEFELYKRLAERKLVAGQEDIIIEEASRLARERDVQRATGGVRVRELSA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: MNMA_STRPI
Sequence: MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLSQEQLQKTMFPLGHLEKPEVRRLAEEAGLATAKKKDSTGICFIGEKNFKNLLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQGFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFAEPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_VEREI
Sequence: MSAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLVATDDARILQACAAHGVEAILTRADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPELIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVLDARGLAQYFSRAPIPFARNPAEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALWHGHRIAVHLTAAAAGPGVDTPEDLERVRRLLL
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBMC_SERP5
Sequence: MTVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAPERLRADVVFTVADDFVLPTSGSEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELPASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_CORGB
Sequence: MAKEGLPAVELPDASGLKVAVVTARWNAEICDRLHKHAVDAGRAAGATVSEYRVIGALELPVVVQELARTHDAVVALGCVVRGGTPHFDYVCDSVTEGLTRIALDTSTPIGNGVLTTNTEEQAVERSGGEGSVEDKGAEAMVAALDTALVLSQIRATEG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RBFA_HERAR
Sequence: MAKHSKSIPGRGLRVADQIQRDLSEIVAFELKDPRVGMITITEVQVTPDYAHAKVFFTMLSDNKDEIKNTVSGLSAASGYIRGQLGRRLSIHTLPELHFVHDTSTARGIEMSKLIDEANATRAKDAED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_SYNFM
Sequence: MIGGIGMPELIVILVIVLIIFGAGRLPELGAGLGKGIKNFRKATSELESAATGEKKPEELEEKK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MNMA_SHESW
Sequence: MTSIEPTHTGKKVIVGMSGGVDSSVSAYLLMQQGYQVEGLFMKNWEEDDNNEYCAAAEDLKDAQAVCDKLGIKLHTVNFAAEYWDNVFEYFLAEYKAGRTPNPDIMCNKEIKFKAFLEFADEILDADYIAMGHYVRRRDNSDGSTQMLRGVDGNKDQSYFLYTLSHEQVARSLFPVGELEKHQVREIAKEMGLITHDKKDSTGICFIGERKFTEFLGTYLPAQPGNIETPEGEVIGTHQGLMYHTLGQRKGLGIGGMKNSNDDPWYVVDKDLERNVLIVGQGGHHPRLMSNGMTVNQLHWVDRTGPVDGCHITVKTRYRQQDVPCTLTYTDEHTLRVVFDEPVAAVTPGQSVVFYDGEVCLGGGIIDQLIRG
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAXC_CHLFF
Sequence: MISNGSKTRKNLGAIALAGMVISSMIGGGIFSLPQNMAASAGAGAIILAWILTGIGMFFIANTFKILSLVRPDLTTGIYMYSREGFGPYVGFTIGWGYWLCQIFGNVGYAVMTMDALNYFFPPYFKGGNTIPAIIGGSILIWVFNFIVLKGIRQASFINVIGTICKLIPLLIFIIITAFFFKLAIFKTDFWGHTATKTQPLLGSVTSQLKSTMLVTLWAFIGIEGAVVMSARAKSPNAVGKATILGFSGCLIVYVLLSLLPFGSLFQHQLAGIANPSTAGVLDILVGRWGEILMNIGLLIAILSSWLSWTVIVAEIPYSAAKNGTFPEIFTIENAAHSPKVSLYITSALMQVAMLLVYFSTNAWSTMLSITGVMVLPAYLASAAFLVKFSKDKKYPNKGPIKSFTAKYTGILAVIYSIWLIYAGGIKYLFMAIVLLALGIPFYIEAGKKGKNAKTFFAKKEVTKITIIAFLALLAIFLFSTERIRL
What is the function of this protein?
Catalyzes the exchange of L-arginine for agmatine.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Arginine/agmatine antiporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUT_ECO8A
Sequence: MKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLDDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: PDUN_CITFR
Sequence: MHLARVTGVVVSTQKSPSLVGKKLLLVRRVSADGELPASPVSGDEVAVDSVGAGTGELVLLSSGSSARHVFSGPNEAIDLAIVGIVDTLSR
What is the function of this protein?
The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Bacterial microcompartment shell vertex protein PduN, Bacterial microcompartment protein pentamer, BMC-P, Propanediol utilization protein PduN.
What is the protein family that this protein belongs to?
Belongs to the CcmL/EutN family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: HDFR_ECO8A
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: MMGT_ARATH
Sequence: MNLGFLVGVFGVLILSHAAYSTIQYRGLLKIMEEEFSRPPINVILELIIGLALCMWAALTFPGKFLSIHPDSDENRAVFLPDNSDFMIFNHRGRLFPPQIDMKF
What is the function of this protein?
Mediates Mg(2+) transport.
What are the official names of this protein?
Membrane magnesium transporter, ER membrane protein complex subunit 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: HBA_CHAMP
Sequence: VLSPADKSNVKAAWDKVGGSAGDYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVGDALGNAVAHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTVACHHPNDFTPAVHASLDKFLANVSTVLVSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: YWOB_BACSU
Sequence: MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEVTPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIVNIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR
What are the official names of this protein?
Uncharacterized protein YwoB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPF_SHEB5
Sequence: MNFNATLIGQTVAFIIFVWFCMKFVWPPLMNAIEERQKRIADGLADADRAVKDLELAQAKATDQLKEAKVTANEIIEQANKRKAQIVEEAKTEANAERAKIIAQGKAEIEAERNRVKEDLRKQVATLAIMGAEKILERSIDPAAHSDIVNKLVAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RN149_MOUSE
Sequence: MAARRRPAAGVGARDALAVLALALCTPGVGGGALEWYSAMVSIEYVDPQSNLTVWSVSESGRFGESSLREERQGLVGVPRAPAPAEGCAPDTRFVAPGALGNAPWVALVARGGCTFKDKVLAAARRNASAVVVYNLESNGNATEPMSHAGTGNIVVIMISYPKGREIFDLVQKGIPVKMRIEIGTRHMQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQFGSQNHRKETKKVIGQLPLHTVKHGEKGIDVDAENCAVCIENFKVKDVIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGDPEDTQELPTPEAAPGRVSVGNLSVTSQDEERSESNLPSSSSSESGPHRPCLKEDAGEDTALLGAGRSEPQHGGSIC
What is the function of this protein?
E3 ubiquitin-protein ligase.  Ubiquitinates BRAF, inducing its proteasomal degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF149, Goliath-related E3 ubiquitin-protein ligase 4, RING finger protein 149, RING-type E3 ubiquitin transferase RNF149.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SMIM9_HUMAN
Sequence: MEPQKLLIIGFLLCSLTCLLLETVASSPLPLSALGIQEKTGSKPRSGGNHRSWLNNFRDYLWQLIKSALPPAAIVAFLLTSALMGILCCFTILVVDPVH
What are the official names of this protein?
Small integral membrane protein 9.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: THII_HALS3
Sequence: MLPPGADSVVVRHGDVGVKSSHVQSDMERTLRDNVAAMLADRGVPGDVEREWGRVLVRSPAPGRAADAAADTFGVVSASPAVSVAPDLDAISDALAAAARAHYDGGAFAVDARRAGTHDFDSHDVNRVGGDAVWAAVEDDFQPVVDLDDPDITFFVEVRDAEAFVFLTHRDGPGGMPLGTQQPLVALVSGGIDSPVAAWESMRRGAPVIPLYLALGDYGGPDHRARAEAAVRTLDDYAPNHDLSLRVAPAGDAIDRLAAATGRTRMLSFRRFMYRVAEHVAEHAGAAGIVTGEAVGQKSSQTTANLGVVDRATTLPVHRPLLTWDKQRITAAARSIDTFRDSSLDVGCNRLAPRQPLTAAPIESVRADEPDALFEWARAVAADTGPVEVAVA
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_CLOBB
Sequence: MKKIAILTSGGDAPGMNAAIRAVVRTAIDKGLEVMGVQRGYSGLLNGELFAMNRTSVSDIIQRGGTILRTARCPEFKDEEVRKRAVKILNAYGVDALVVIGGDGSFMGAKLLSKLGIKTIGLPGTIDNDLAYTDFTIGFDTALNTIVDAINKIRDTSTSHERVSIIEVMGRDCGDLALHAGISSGAEAIIVPEMGEFDRDALCRTILDGKNHGKTHSIVILAEGIGGAEELSKYVQELTGIEARATILGHIQRGGAPSASDRVLASRLGARAVEVLLQGETSRVIGIRDNQIVDQDIDEALAIESKFDLDLYNVAEVLSR
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_ALCBS
Sequence: MFDIGFTELTLIFIIGLVVLGPERLPTVARTLGHWIGRARSTLNHLKSELERETITQDMQERMEKQMRQMGLDEDSIREAKDSLLSPEQIARSRTPRDKPLSAALNNDESPSDKDSADKNNHDQDSRRHD
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DRE21_TRYCC
Sequence: MSSTTTQAFSLKTRQAVDEDALLTEEDRVVKEATKGEDCTTRRRACKNCTCGRAELERKMLAEGKKVEMPQMPAGGCGNCAKGDAFRCATCPFLGQPAFDNTSDGKVKLNLTDDI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog 1, Fe-S cluster assembly protein DRE2 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: YQEY_BACSU
Sequence: MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDSLTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRTIVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS
What are the official names of this protein?
Uncharacterized protein YqeY.
Protein: GAG_FFV
Sequence: MARELNPLQLQQLYINNGLQPNPGHGDIIAVRFTGGPWGPGDRWARVTIRLQDNTGQPLQVPGYDLEPGIINLREDILIAGPYNLIRTAFLDLEPARGPERHGPFGDGRLQPGDGLSEGFQPITDEEIQAEVGTIGAARNEIRLLREALQRLQAGGVGRPIPGAVLQPQPVIGPVIPINHLRSVIGNTPPNPRDVALWLGRSTAAIEGVFPIVDQVTRMRVVNALVASHPGLTLTENEAGSWNAAISALWRKAHGAAAQHELAGVLSDINKKEGIQTAFNLGMQFTDGNWSLVWGIIRTLLPGQALVTNAQSQFDLMGDDIQRAENFPRVINNLYTMLGLNIHGQSIRPRVQTQPLQTRPRNPGRSQQGQLNQPRPQNRANQSYRPPRQQQQHSDVPEQRDQRGPSQPPRGSGGGYNFRRNPQQPQRYGQGPPGPNPYRRFGDGGNPQQQGPPPNRGPDQGPRPGGNPRGGGRGQGPRNGGGSAAAVHTVKASENETKNGSAEAVDGGKKGGKD
What is the function of this protein?
Involved in capsid formation and genome binding.  Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity).
What are the official names of this protein?
Gag polyprotein.
What are the subcellular locations of this protein?
[Gag protein]: Virion. Host nucleus. Host cytoplasm. Note=Nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal (By similarity). In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids. SUBCELLULAR LOCATION: [p3]: Virion. Host cytoplasm, host perinuclear region. Note=Gag proteins assemble in the cytoplasm to form the capsids.
Protein: Y094_HAEIN
Sequence: MSELLINDYTRKGFVDGLCLRLPTICIRPGKPNKATSSFVSSIIREPLHGETSICPVAEKMAFSFIKFLGKKKEEWALAITGYVVSIPIVLPILIIFIKAILDLGK
What are the official names of this protein?
Uncharacterized protein HI_0094.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SNX2_BOVIN
Sequence: MAAEREPPPLGDGKPTDFEELEDGEDLFTSTVSTLESSPSSPDPASFLAEDISTNSNGPKPAEVALDDDREDLFAEATEEVSLDSPEREPILSSETSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSRDEIEEEANGDVFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENQDQQLRKLHASVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRVKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC).  Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity.  Required for retrograde endosome-to-TGN transport of TGN38.  Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity).
What are the official names of this protein?
Sorting nexin-2.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles. Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (By similarity).
Protein: MIAA_CUPMC
Sequence: MSVQSHPPVVCLLGPTASGKTAAALELAARTPVEIISLDSALVYREMDIGTAKPTHEELASVPHHLIDIIDPLESYSAAQFMTDAERLIGEIRARGRTPLIVGGTMLYYKALTQGLNDLPQADATVRAELDALAAERGWPALHAMLAEVDPITAARLAPNDAQRIQRALEIHRLSGQPMSALLARQADARTFTGAADARYRVIALEPSDRAVLHARIADRYDAMLKGGLIEEVERLRARGDLHLGLPSIRCVGYRQVWEYLDGDCDFATMRERGIAATRQLCKRQLTWLRSTPERIGIDCLAPDYVARVADAAGW
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.