PharMolix/UniProtQA huggingface dataset:
Protein: DPOE_CRYNJ
Sequence: MPSRGSFRGRGRGSGSGFGSNTRFTGRRRGRGGGGGGGGVAYGIDRRPATSTNQANREDGTAATEKFEEVKVYDEIDEKIGFWRFESVRAEGEEKVGWLVNMHQTLVPSDVHPGGLAAVDYYFIQDDGGSFKVSIPYEPYFYLTCRGGTESIVEEWLLKRYEGIIIRIEREKKWDLSLPNHLLSAPPVFLKLFFHNTADLQTIRRDLLPLARSNSEKFTAVDAYADVVSAEAAANGHGDDENRAWGAEDDTKKKKDKEPSECIIEVREHDLAYHLRVAIDLNIRVGLWYTVTSRTGVITLERIPDRVKRADPVVMAYDIETTKQPLKFPDQQTDQIMMISYMIDGMGYLITNREIVGEDIDDFEYTPKDEYPGEFTVFNEPDEPAVIRRWFEHIRDSKPTVIATYNGDSFDFPFVDARAKIHGISMYEEIGFKPDIEEEYKSRSTMHMDCFRWVKRDSYLPQGSQGLKAVTTAKLGYNPIELDPELMTPYAIEQPQILAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLSPDEVLRKGTGTLCETLLMVEAYDAHIIMPNRHEDPHGVTYEGHLLASETYVGGHVEALEAGVFRSDIPTHFKIVPSAIQELIDDLDAALRFSLIEEGQVKLEDVENYDEVKQQIQTALETMRDEPNRFDNPLIYHLDVAAMYPNIMLSNRLQPDSVKEEADCAVCDYNRPDKKCDRRMEWAWRGEYFPAKRDEVNMVRYALEQETFPPKRPYDPKRRFVDLTPTEQSALLHKRLGDYSRKVYKKTHDTKIVTKTTIICQRENSFYIDTVRAFRDRRYEYKGLHKTWKKNLDKAFEEGGAVATVDEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGATIIQMARQLVEQIGRPLELDTDGIWCMLPGVFPEDFNFKLKNGKKFGISYPCTMLNHLVHAQFTNDQYHELVNNDSGTYNVKKENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNPDGSLAELKGFEVKRRGELQMIKIFQSQIFDKFLLGKTTEECYAAVATVADQWLDILQSKASSLHDDELVDLIAENRSMSKTLAEYAGQKSTSISTARRLAEFLGEQMVKDKGLSCRFIISAKPNGAPVTERAVPVAIFTAEEPVKRHYLRKWLKDNSLTDFDLRTILDWDYYTERLGSVIQKLITIPAALQKVPNPVPRIRHPDWLYKRIATKEDKFQQHKITDMFTKLKDMEDLGDGQKKVGPKLAVVRRRNRKEQEKESEVEEVPPEPEYDYAGYIRIMKKKWRKQRQEKARARKSGLRQDGTISSMLRTQTSSMNSKQWDVIQIASTNRPGEFKLWLAIDGTFQSVRLKVPREFYLNFKEDPEPQMLATDRYEAVEVVRTLPRGQPARHLYKLSVDEVLFMEGESHFSTLINNPNVDGAFELQVPLVVRALLSLGTSCALRSNILGGLNRGLDKGFDLVDLERSGNLSRRKYLNEGRGIRYHFLFHAVADQRHIIGLFSPDSTNASIYLVDRAKNRQQLPNPLKFYTDRVERAERGVFSYPDMLDFTTSYHSSESSAFKALGKDLQAINHGLNVIALCSPFEHSYYQAKAPVYSNFPFITYRLGKEEDPGLMWLLQTSRRMIGLYLRLSSWLKEQIQIASHFDVPIGNLGADIAVFLADIEFARRLKQQDMLIWWSSTPRPDLGGSEEDANSSEDLVSPHISNRGCYSSTVLEMEVSDLAINAVLQSALVNEMEGSGTGSLAFDSASHNLDEYAKGAVNTSVMLGDAVLSTQTFGVLKSMLRAWYADKARAHVKGDSLSPAEIVVDQFWRWISSSTSSMFEPALHRFLHGLMRKTFLQLLAEFKRLGTQVVYADFGRVFLLTSKPDAGSAFAFAKYLVAAANSQELFRHLIIDVAQFWNYLAWMDVANFGGVKVSPETAASREPPAKRFEISMDWNIQSFLPGTLQPVFERNVASFIFSLYSAKRSSSDGREPLRVIHSLNIDQPGTEATSTMNPTKEKEKKAASKSISQTLTRRLLSDIAAVKRQQAAVHLEPEEAYTLAFPDLPGARSKRINPTLELIKAITEVYSLASEHSIEVQILKRNLLDLIGVKEFSSDAAFNPPCESIEVPMVICKKCNAIRDVDLCRDPDRLPSVNPDSGEMLEPARKNWVCHKCDSEYDRFQIEQPLIEMVTKTITNYQIQDVICLKCSQTKSDNLAATCKCGGGFRTTSNRNELKTKLKMIKSVCDYHKLPFAGSYVEETLSRW
What is the function of this protein?
DNA polymerase II participates in chromosomal DNA replication.
What are the official names of this protein?
DNA polymerase epsilon catalytic subunit A, DNA polymerase II subunit A.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: STHA_ECOLU
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRS1_ASPFU
Sequence: MAPNAATKKRAAARDDDFVLTLSDDENDIFENGVEEDGDNAQEDTLSSSKKRKREAAEAPKGKNKKQKQLKKSKKGESAAGAVSDDQSSEEDEAEAMDAGEDDGALDSEFEFDVGGNANTGVIEGFDGWEARNGASLADAPKNGDKKAVDIDDIISRRKAKKEAELKKKQQKEKKRREEEGEEESEGEDADSDGGMSVDFQDDELLAADGFGMGADGADESDDDVENGSNDSDDSEGKGSEDEESGDEYNDDDAASDNDSVATPVHHPDDEAASDEESEAESEVDAEEAEKRKAFFAPEEKSTAVSTFNRSFQDFNLSRPILRGLASVNFTTPTPIQQKTIPVALLGKDIVGSAVTGSGKTAAFVVPILERLLFRPRKVPTSRVAILMPTRELAVQCYNVATKLATHTDITFCQLVGGFSLREQENILKKRPDVIIATPGRFIDHMRNSPSFTVDTLEILVLDEADRMLEDGFADELNEILTTIPKSRQTMLFSATMTDSVDKLIRVGLNRPVRLMVDSKKNTSMNLTQEFVRLRPGREDKRLGYLLYLCNEIYTGRVIVFFRQKREAHRVRIVFGLLGLKAAELHGSMSQEQRIKSVENFREGKVAFLLATDLASRGLDIKGVETVINYEAPQSHEIYLHRVGRTARAGRSGRACTIAAEPDRKIVKSAVKAGKAQGAKIVSRVVDPAVADEWAAKAKGLEDEIEEVLQEEKLEKQMAQAEMQVTKGENLIKHEAEIMSRPKRTWFETERDKRAARKLGATELNGPSKKDKVKLSNKDKKRLDDARQRHEGNIGWKKGKADREAPKQGKNKGGKTKSDKKNKIKMKGKK
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase drs1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EI3EB_DANRE
Sequence: MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSETNMVDFAMDVYKNLYPDKEIPHSLRDKRTTVVAQLKQLQSETEPIVKMFEDPETQRQMQSTRDGRMLFEYLADKHSFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPSTDRNALSSLWGKLASEILMQNWEAAMEDLTRLRETIDNNTVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIELFLYQPQYLNAIQTMCPHILRYLSTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDSAQRKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISISMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKISHSNRNETPNWAAQDTGFY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E-B, eIF3e-B, Eukaryotic translation initiation factor 3 subunit 6-B.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RSMA_DEHMC
Sequence: MEKDVPLLVASAPSLMAQAKEMMEGYTLKARKGLGQHFLISQGVLNKILAAADLKPTDTVIEVGPGLGALTEELLKRAGQVIAVELDDKLIDALTEKFKGYPNFRLIHSDILKTSPEEILGQDVPYKLVANLPYYITSAVLRQFLEAKLKPESMVVMVQKEVAKNIVAKTGDMGLLTLSVRFYGNPSLVSVVPGGAFYPPPEVDSAIVKIVIPQTTIMEGVSEVDFFKLARAGFGTRRKTLLNALAQGLGISKPVILSLLNGAGIDPARRAETLSMEEWKKLCLEYAGNPC
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF272_ARATH
Sequence: MSSKIKFVALLIVVISLLLNNAQSTREILSAEICGWNDPAVHCKTKEDCFEKCGGRPAKKVFCVRPGDHSYDRLCCCRA
What are the official names of this protein?
Defensin-like protein 272.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: CXQA_CONRG
Sequence: CKGQSCSSCSTKEFCLSKGSRLMYDCCTGSCCGVKTAGVT
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).  This toxin inhibits rat Cav2. 2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2. 8 uM), whose effect is partially reversed after washing.  In vivo, when injected into mice, it shows both an analgesic effect in acute thermal pain at 30 and 45 minutes post-injection and an anti-nociceptive effect in a formalin chronic pain test.
What are the official names of this protein?
Omega-conotoxin RsXXVIA, RsXXIVA.
What are the subcellular locations of this protein?
Secreted.
Protein: MED8_COCIM
Sequence: MASLNQEQLKILEQTRQRLLHLTQSLGSLSNSINQSDPLPPWSSLQSQATIISNNLLSISHLLTEHQELLSSIVAYPTPNFPGRTESTILHQLMRTKLEPRVEEWVARGRNVARHNTASSQIRAQQGAAAEGETVRLSVDELLDLWHWAPIAANMEARRRDWGGDYTLEEKEMGVKNVITGLKRQLDEGDEEDEEEEEEEEDMQGEEMEVVVGAHTKAGGGSGVEFDIARGSSHIPSKPVAPGMPLDDIFRFMMTGAPPRPR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GARL_ECOSE
Sequence: MNNDVFPNKFKAALAAKQVQIGCWSALSNPISTEVLGLAGFDWLVLDGEHAPNDISTFIPQLMALKGSASAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVETKEEAEQAVASTRYPPEGIRGVSVSHRANMFGTVADYFAQSNKNITILVQIESQQGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQKAIQHIFNRASAHGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRSATQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: UBIA_ECO7I
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMP_LARHH
Sequence: MDVRTLLETTLSGLGYELVDFELGHGGLMRVFIDAPAGIALDDCVKVSNHLTRLFTVENIDYDRLEVSSPGLDRPLTREADYARFAGERVRIKTRLPIGERKKFAGTLVGLADGQVELDIDGERVAIPLASIDKARLDPQF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE66_MYCTU
Sequence: MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVAPVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRPAGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG
What are the official names of this protein?
Uncharacterized PPE family protein PPE66.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUXS_BACCZ
Sequence: MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAKRLMNFWLSQDKDELEKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RS8_TRIL1
Sequence: MSMTDPIADMLTRIRNANMVKLQKVDIPSSNVKVNIAQVLKQEGYIKNYKVIADNRQGVLRVYLKFIDEKDPVINEITRISKPGSRTYVDSESIPTIKNGLGIAILSTSKGIMTDASARQAGIGGELLCTVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GLCE_MOUSE
Sequence: MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRHLSSGFRVDGLEKRSAASESNHYANHIAKQQSEEAFPQEQQKAPPVVGGFNSNGGSKVLGLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRSPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDRNIRPNEWTVPKGCFMASVADKSRSTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKLLTNGSVSVVLETTEKNQLFTVHYVSNTQLIAFRDRDIYYGIGPRTSWSTVTRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAHMAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQAISTLVRAYLLTKDYVFLSSALRATAPYKFPSEQHGVKAVFMNKHDWYEEYPTTPSSFVLNGFMYSLIGLYDLKETAGETLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPIFKEFVKRWKSYLKGSRAKHN
What is the function of this protein?
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains.  This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
What are the official names of this protein?
D-glucuronyl C5-epimerase, Heparan sulfate C5-epimerase, Hsepi, Heparin sulfate C5-epimerase, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase.
What is the protein family that this protein belongs to?
Belongs to the D-glucuronyl C5-epimerase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: 071L_IIV6
Sequence: MSIIEIITDSSINTTTDIGIVNLTQIEPLLCGFITIDTGNVYDLISSACMFMKQFSPYNLRLFESSYIEENTMTFIRVNSENPAYFVCRVNSLGNDNNEEKIQKIKNNLEINFLYNNIIHDESNILIIG
What are the official names of this protein?
Uncharacterized protein 071L.
Protein: SYP_RICB8
Sequence: MLLSKYFLPVLKEDPSEAQITSHKLMLRSGMIRQQAAGIYSWLPLGLKVLKNIENIVRSNMDKAGCLEVLMPCIQPAHLWVESGRFDNYGKEMLKFQDRHDNTLLFGPTNEDMVTDIFRNNIKSYKDLPKNLYHIQWKFRDEIRPRFGVMRGREFLMKDAYSFDIDEESAVKTYNQMYKAYINTFRDLGVFAVPVIADNGPIGGKLSHEFHIIAETGESNIYYDKRFKTLKDNPDIDIEEIKSWYAAAEEKHDASKLSSDKEITSSKGIEVGHIFYIGTKYSVNMNALINDEHGKLTPIEMSSYGIGISRLVAAIIEANSDAKGIIWPIAVAPFKISLINLNIHDSKCLELAERVYNELLAQNIEVLYDDTDVRAGSKFATHDLIGSPYQIIIGPKKAANNIVELKNRKNGEIEDIDLNKRALNSYLTFFNS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZRK4_ARATH
Sequence: MNDQKMSCWRKKSKKKNSEANQRQRWFQENGKVLLEDLIELCNGKSNPIKTFSAEEILQATDNFSESNLVIRFNFMYRGILQNRPVLIKRATWNYYKSDTLEKICRDIAVSSMVSGHKNFLKLLGCCLEFEHPVLVCEYAERIPFNTPNPEMLLPWRMRIKIAKEIAIAVSYLHTALSRTMIHTDIQPFNIFVDSNGTAKLSDFCLCIAIPEGETFVKVHADRVEGTLDYLEYNYAATGLITEYTDVFSFGVLLQNFFTRTYGVVDCCCSEDESLFEEFEDKQNVMNLRISDRISKFVEEGRIFDMLDPKMLESMGDDETEEHKIRRMKAVLMLSLRCTGHRGDVPKMMEVAKELKRIERWT
What are the official names of this protein?
Serine/threonine-protein kinase ZRK4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ZRK subfamily.
Protein: TTCA_SHIDS
Sequence: MQENQQITKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLLEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDSNLFDFKGITHGSEVVNGGDLAFDREEIPLQPAGWQPEEDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_TROWT
Sequence: MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELAIYSVLWSEHCSYKSSRRHLRQLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHNHPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGAASDPDTQRVADGVVSGISFYGNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRDGIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGISCAASELAHNGRVGIRLDLSAVPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNRWGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYNRPVKKPAYLIRRSAANRLPVTNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALSCDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCRGLSDACKRLEIPITGGNVSFYNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIYLLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNLLVAGAKKRVFESAHDLSEGGLIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYEYTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOE_CERSS
Sequence: MKVLWAALVVTLLAGCGADVEPGPEVQLGKEWATWQASQPWEQALGRFWNYLRWVQTLSEQVQEQLLSSQVTEELTALMDDTMKEVKACQSELEEQLGPVTEETKARVSKELQAAQARLGADMEEVRSRLAQYRGELQAMVGQSTEELRGRLSAHLRKMRKRLLRDAEDLQRRLAVYQAGIWEGAERSVNTLREHLGPLAEQAATVHTLVSKPLQERAEAWAQRLRGRLEKAGFPVGDRLDEVREQVQEVRAKVEEQANQVRLQAEAFQGRLKSWFEPLVQDMQQKWAELVEKVQLAVGAVPTSVPSEKQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: DAPA_RICB8
Sequence: MNNIFKGLITAIITPFRDNKLDLNALEKILEYQINAEVNAVVIAGSTGEGSSLSFEEYKLLLQTAKDIVNKRIPVISGCSSNNTACAIELAAESTKIGVDGFMISPPSYLKPTQGGIYKHFEAIHEASNLPIMLYSVPSRTGVDFTDETILKLSKLSRILALKDAGIDLERPLRIKSVINKELNLLCGNDDLSLAFNAQGGVGCVSVASNITPKLCKELQEKWHNNDVKGALGIHQRLLPLYKALFVESNPIPVKYAMYYLGFCTNEIRLPLTEATDTTKKQIEEIITSLSIKV
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDM3_ARATH
Sequence: MSLYSDGLSSDQYFLVNFIMSNYLGPDVYSDNPRCSSSQRLARGLPPYTLMHIGSSSLTVSQLQNLYYNVLRNAKSSLLLHPDMIYMYLKGYLPLEPSGKFPQFTHFFPTNLHPQKRYSPSHEIVKGIVVIDDPAVGFINKEELQRFRCLSRLDDLKIDRVTSLSPRVNLDESRETEQDCSRNGDATANGVVTNEDYNSSGELQETCKRKEGEDAVASCVISEPERLSGDIPESQGMKQDCSRNGESAFSGIVSDQDYYSFVKLPETCKRKNKEEEAVTGHAVSGTSKTPERFRETYKRRRFKNSSKKATNKNGETLMEREKTDKPIPFSSEMKESDAEPSVVTTGTASKETLGSSVGVVDIGVNKVAYFFQVALPGVRKDYGEFSCEIESDGKVILEGSTTRGEKNIKRHSRVFEMNIRKLCPPGPFKLCFNLPGPVDPRLFSPNFRSDGIFEGVIIRHKNS
What is the function of this protein?
Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed:25684209).
What are the official names of this protein?
Increased DNA methylation 3, Alpha-crystallin domain-containing protein 51.9, AtAcd51.9.
What are the subcellular locations of this protein?
Nucleus.
Protein: FLIW_CLOBM
Sequence: MNLNTKYHGSIEYEEKDVIYFQKGIPGFEELKKFIIFPVEDNEVFLVFHSIENKDIGIIVTSPFNIEKDYEIQLEEEQITNLKIQDEKDALVLNTVTLDSDIDKITVNLRAPIIINIKEKIGEQIIINSDKYKVKHPLFKEEA
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.