PharMolix/UniProtQA huggingface dataset:
Protein: PFKA_BACCE
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIFHDIEVYGIYHGYAGLISGHIEKLELGSVGDIIHRGGTKLYTARCPEFKDPEVRLKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEQGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLADGAETILIPEEEYDMEDVIARLKRGSERGKKHSIIVVAEGVGSAIDIGKHIEEATNFDTRVTVLGHVQRGGSPSAQDRVLASRLGARAVELLIAGKGGRCVGIQDNKLVDHDIIEALAQKHTIDKDMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADB_PSEE4
Sequence: MIYEGKAITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSSGKDVFIVGADITEFVDNFKLPEAELVAGNLEANRIFSDFEDLEVPTVAAINGIALGGGLEMCLAADYRIMSSSAKIGLPEVKLGIYPGFGGTVRLPRLIGSDNAIEWIAAGKENRAEDALKVGAVDAVVAPELLQAGALDLIKRAISGELDHKAKRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFAKLARTSVAESLIGLFLNDQELKRKAKAHDEIAHDVKQAAVLGAGIMGGGIAYQSAVKGTPILMKDIREEAIQLGLNEASKLLGKRVEKGRLTPAKMAEALNAIRPTLSYGDFGNVDIVVEAVVENPKVKQAVLAEVEGQVKEDAILASNTSTISINLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSEVAVATTVAYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAVDALYEANRLGQKNGKGFYAYETDKRGKPKKVADASVLDVLKPVIFEQREVSDEDIINWMMVPLCLETVRCLEDGIVETAAEADMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADKYADLGPLYHATAKLREMAKNGQRFFN
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: RLMKL_SALPB
Sequence: MNSLFASTARGLEELLKTELEKLGAVGCQVVQGGVHFQGDTRLIYQSLMWSRLASRIILPMGECKVYSDLDLYLGVQAINWTEIFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRESPDLRINVWLNKETASIALDLSGDGLHLRGYRDRTGLAPIKETLAAAIVMRSGWQPGTPLLDPMCGSGTLLIEAAMWATDRAPGLHRGHWGFSGWAQHDETIWQEVKAEAQTRARKGLAEYSSHFYGSDSDARVIERARSNARRAGIGELITFEVKDVAQLSNPLPKGPYGTVISNPPYGERLDSEPALIALHSLLGRTMKNQFGGWNLSLFSASPDLLGSLQLRADKQFKAKNGPLDCVQKNYHIAETTADSKPATVAEDYANRLRKNLKKLEKWARQEGIECYRLYDADLPEYNVAVDRYGDRAVIQEYAPPKTVDAQKARQRLFDIIAATLSVLGIPPNKLVLKTRERQKGKNQYQKMSEKGEFLEVSEYNARLWVNLTDYLDTGLFLDHRIARRMLGEMSKGKDFLNLFSYTGSASVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLSGRAHRLIQADCLGWLREANEQFDLIFIDPPTFSNSKRMEESFDVQRDHVALMKDLKRLLRKGGTIMFSNNKRGFRMDLEGLAELGLTAQEITQKTLSPDFARNRQIHNCWLIRAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1060_STAS1
Sequence: MKLSFHGQSTIYFEANGKKVIVDPFITGNGQSDLDASTLKVDYIILTHGHGDHFGDTIELANRNHATVIGSAELGDYLTTYHNVENVRPMNIGGKAEFDFGNVKFVQAFHSSSLTDENGVPVYLGMPMGLILEIEGKTIYHTGDTGLFSDMKLIADRHPVDVCFIPIGDNFTMGIDDASYAINSFIKPKISVPIHYDTFELIEQDPNKFKQAVSVGEVQILKPGEDVSF
What are the official names of this protein?
UPF0173 metal-dependent hydrolase SSP1060.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: KLF18_HUMAN
Sequence: MDSSLLQAIEEIEKFFQHLSERHTEQAETPDAPEPQNCMPLTAHAEESQHESTQSKTMPPLGSTMMTSACTNIPGTVLTQDLTMHPLKALEDLSETYSMGQKVTSFDQVKHTAGSQMTDVTVTPKSSPTDCQKTTITASNMTISNESSQLNTPSSDQTLNESQIPALLGDQMKTLSDNQTLCGDQVTFSSDQTLTDGHTVTSGSDETLSGGQMTTSLDLYGGQMMTSIDNQTLCGEQMTTSSGNQAFYGRQMTTSTGNQTLCGEQMTTSTGNQALYGGQMTTSASNQTLCGEQMTTSTSNQTLCGEQVMTSTGNQALCGGQMTTSTGNQNLYGGQMMTSTGNQTLYWGQMMTSTGNQNLCGEQVMTSTGNQALCGGQMTTSTGNQNLYGGQMMTSTGNQTLYWGQMMTSTGNQNLCGEQVMTSTGNQALCGGQMTTSTGNQNLCGEQVMTSTSNQTLCGEQTTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQTLYWGQMMTSTGNQNLCGEQMTTSTGNQALYGGQMTTSTSNQTLCGEQMTTPTSNQTLCGEQVTTSTGNQALYGGQITTSTSNQTLCGEQMTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQALYGGQMTTSASNQTLCGEQMTTSTSNQTLCEEQVMTSTGNQALCGEQMTTSTGNQALYGGQMTTSTSNQTLCGEQTTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQTLYWGQMMTSTGNQNLCGEQMTTSTGNQALYGGQMTTSTSNQTLCGEQMTTPTSNQTLCGEQVTTSTGNQALYRGQITTSTSNQTLCGEQMTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQNLYGGQNMTSTDNQALYGGQMATYSGNQTLYGDQMLTLQVGNMTTLTDDHSLYGGYMMSHQFSSLPYPGFLCFSSSHLIQGQLPKQKTQSCQFWKNPEVSRPYVCTYEDCKMSYSKACHLRTHMRKHTGEKPYVCDVEGCTWKFARSDELNRHKKRHTGERPYLCSICSKNFARSDHLKQHAKVHNIRPGL
What are the official names of this protein?
Kruppel-like factor 18.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KLOTB_MOUSE
Sequence: MKTGCAAGSPGNEWIFFSSDERNTRSRKTMSNRALQRSAVLSAFVLLRAVTGFSGDGKAIWDKKQYVSPVNPSQLFLYDTFPKNFSWGVGTGAFQVEGSWKTDGRGPSIWDRYVYSHLRGVNGTDRSTDSYIFLEKDLLALDFLGVSFYQFSISWPRLFPNGTVAAVNAQGLRYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKAHSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTDNMEDVINCQHSMSSVLGWFANPIHGDGDYPEFMKTGAMIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSLNLRQVLNWIKLEYDDPQILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEIRVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPLKESTPDMKGRFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVRLKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKVNRQVLRYYRCVVSEGLKLGVFPMVTLYHPTHSHLGLPLPLLSSGGWLNMNTAKAFQDYAELCFRELGDLVKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSLHCDWAEPANPFVDSHWKAAERFLQFEIAWFADPLFKTGDYPSVMKEYIASKNQRGLSSSVLPRFTAKESRLVKGTVDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSSPSRLAVTPWGVRKLLAWIRRNYRDRDIYITANGIDDLALEDDQIRKYYLEKYVQEALKAYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFRAKSSVQFYSKLISSSGLPAENRSPACGQPAEDTDCTICSFLVEKKPLIFFGCCFISTLAVLLSITVFHHQKRRKFQKARNLQNIPLKKGHSRVFS
What is the function of this protein?
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis.  Probably inactive as a glycosidase.  Increases the ability of FGFR1 and FGFR4 to bind FGF21.
What are the official names of this protein?
Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein.
Protein: GATA_PSEU2
Sequence: MHQMTLAEIARGLADKKFSSEELTRVLLSRIATLDPQLNSFISLTEDLAITQAQAADARRAAGENGPLLGAPLAHKDLFCTQGIRTSCGSLMLDNFKAPYDATVVSRLASAGTVTLGKTNMDEFAMGSANESSHYGAVKNPWNLECVPGGSSGGSAAAVAARLLPAATGTDTGGSIRQPAALTNLTGLKPTYGRVSRWGMIAYASSLDQAGPMARTAEDCALLLQGMAGFDPQDSTSIDEPVPDYSASLNTSLKGLRIGVPKEYFSAGLDPRIAQLVHESVRELEKLGAIVKEVSLPNLQHAIPAYYVIAPAEASSNLSRFDGVRFGYRCEDPKDLTDLYKRSRAEGFGPEVQRRIMVGAYALSAGYYDAYYLQAQKIRRLIKNDFMNAFADVDVILGPTTPNPAWKIGAKTHDPIAEYLEDFYTITANLAGLPGLSMPAGFVDGLPVGVQLLAPYFQEGRLLNVAHQYQQVTDWHTRAPEGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: COAX_EXISA
Sequence: MILVIDVGNTNIVLGMYDGDNLVHHWRISTDRTKTTDEYGMLVKSLFDHSNVSFEQVEGVILSSVVPPVIFPLEQMSQRYFNVRPIVVGPGVKTGLDIHVENPREVGADRIVNAVAGIAKYDGPLIIVDFGTATTYCYIDEKRRYHGGIISPGIMISVEALYQRAAKLPRIELATPPTVIGKNTIQAMQSGTYYGYVAQVDGIVNRMKREVGEATVIATGGLARLISEHAETIDHVDSFLTLEGLRLIYERNQK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODD_RHILT
Sequence: MRFKGLDLNLLVALDALMTERKLTAAARSINLSQPAMSAAIGRLRAYFNDELFLMQQRRLVPTPRAEALAPAVREALLHIQLSVIAWDPLVPAESDRRFRIVLSDFMTLVFFEKVIKRVAREAPGVSFELLHVNDDPDERLRSGDLDFLILPDQFMSATHPSAKLFEDKLVCVGCPSNQQLRGKLSLKRFMSMGHVAAMFGRTLKPSIEQWLLLEHGFKRRVEIVVPGFNSIPMLLQGTNRIATLPLLLVRHFEPTIPLQIVDHPLPPLSFTEALQWPLLHNSDPGNIWMRNIILEEASRIETSSERCSQEPRATQSW
What is the function of this protein?
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins.  NodD is also a negative regulator of its own expression.  Binds flavonoids as inducers.
What are the official names of this protein?
Nodulation protein D.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: ITP_HHV7J
Sequence: MDCTNLQFESILNLLKTDVSDNTFLTITAKIEIFSLAAESITADKILSFAKLLPIHNYHFNFIKNHMVFYILNYSTLGFAKRFSIAETLCRELKIFHRTFQSTSKLQNLNNAEVLYQFEKLIESIQVFKAELASPIGKLLRQETMIYDKPTEKSVKYVIIQQNLIKINNLIQDCESIKNCRLIAELIDELYQKVYRWFMQIFTYDDIIFPNDNFLDRLLKMDFCYTYYTASNQHLLSLFEQTIDNQIFIDPSPYFEINPVYSPELQFMSTFSLKIFSKNISAKNEDLYIYPLLKTNFSILTFLSLENIFFHHGFIYHILHRTNITPTEEKKLGKINGFLNTVIQQVLIKKNNLQITFPELLDKIYHLHRIGLNIETAQIFLQMLTTYKPATTNNKLQTFFTNFSIIIFSAYIFFLCIELFSPTFIFHNKKKLILEKQKSIILILGEQFSFIWKEVNEIVDLLFSSTVTETYFKFYSKGADDYEKDFLYKDLMEKWGELFFPLTYSMTTPQKYTDKHVSSTVLKNLCDTAYQSKMETAYESLLPYITHPEFKFIFITHYVRPSLSLITNLTFEEIKDNRRLLILIFACKLLMPSNYLLSHYLLLLHAFTLQIFKVDLGHFSIIHAITQKIFDNINSLTQTIFIPKTNFLVSLLLTAYTVHMQTYVNPWIQKTISENIALLKEYIDFTKKCSSTLATTCYLNLENFAVNMYFGKNKVGSTSLSAFYRTCSKLIEESKLFKDRLQEIKVSKTLFIEMLQNVVKNITKFKDLVSNQTLQNFIIIVERISSHANTTYQDVLNSIDECHFSNMQLIQSFKNIVYVIDVLNTKNIFNFSLASQLIEAKKLVKKQDTYNQLNVQDDFVTVLKSHLNNLFEKQKPTINIERRFMLEGIPDIKQIPFLDVFDERYRLIPQIEKYLHWYIAYSEAAQADLVEPLLLKLG
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: PAND_ACIB5
Sequence: MLSRLLKCKIHRAVVTHAELHYEGSCAIDGVLMDLAGIREYEEIHVWNVTNGKRFTTYAIRGEDNSGIISVNGGAAHQADVGDLVIIATFGDFTEAEANVHKPRLVYANPDNTVNHTANCIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I07A0
Sequence: MKVKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGESSFYRNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRFAFALSRGFGSGIITSNAPMDKCDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSTKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNDECMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: RL20_GLOVI
Sequence: MVRVKRGNVARKRRKKILKLAKGFRGSHSKLFTAANQQVMKALRNAYRHRRTKKRDFRSLWIVRINAQARTEGLSYSRLIDGLHKADVALNRKMLAQLAVTDPEAFAEVARVAKSARPV
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: TRUD_HALS3
Sequence: MREAHPIERAVGMAYYASDSDGTGGRLRDSPADFRVRELEAFDTQPADAPTGDYPWLVVRATLHEWDTNDFARELANTVGMSRERVRWAGTKDRHAVTTQLFAVRDLDAAQVPEIRNADIEVVGRAGRGLEFGDLAGNAFEIVVRDPDAPERAAAVADELAAFGGGTVGTPNYFGQQRFGSKRPVTHEVGLAILRDDWEAAAMAYLGAPTEHEPADSQRAREYVAETRDWTGALAEFPQRLRYERTMLHELADGGSFRDAVETFPSNLQQLFVHAAQSYVFNRIVSERMARGLPFGEPVAGDVVWFADSDADAAVAQPDAARQQRVTDSRVDVMARHCERGRAFVTAPLVGTDTEFADGDPGEITRGVLDDLGLSRADFDLPGEFDSAGSRRAILLRPDLTVSHDPLAFEFALPSGSYATVVLREFLKPSPLAL
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: PYRG_HAEIG
Sequence: MATNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTQDGAETDLDLGHYERFIRTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNEIKDRVIAGAQGHDVVIVEVGGTVGDIESLPFLEALRQLAVQVGREHTLFMHLTLVPYIPTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMIPPNERAKIALFCNVAERAVISLKDVNSIYQIPALLKSQGLDDFVCERFRLTCPEADLTEWEQVLYKQANPVGEVTIGMVGKYTELPDAYKSVNEALKHAGLTNRLSVNIKYIDSQDVETKGVEVLKGVDGILVPGGFGYRGVEGKIRTAQYARENKIPYLGICLGMQIALIEYARNVAGLTKANSSEFDKDCEQPVVALITEWQDAEGNTEVRTDESDLGGTMRLGAQQCHLVSGSRARELYGKETIEERHRHRYEVNNTLLPQIEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAYENHKKSVK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: GTAM_DICDI
Sequence: MENQKKNNFNQIDYFRWADYSKNNNNNNNNNNNNNINNNNNNNNNNNINNNIDNNNSFYRFISPPFNKINNNNNANNFNNINNNNNNNFNNYQLNDGNKISINNILNDNTTTTNTSANQNSANTNKTYNFSKNENGIVYEIDNFILDSNLVREQPFNNFNYLNIINNIQNFLQLISGKVNLLNVILGILVDDVNRYSVNPNSMSIIPSDNFPTPQLPLETNTDLNNTSDCSSTTFSSPPSSAFNSPNLQNDYTQPQNQKSQSSTIVKKNSSKSKSKNNKQSKDDGETNDGESPEIEEKRVIRLDMNLNPNPTIPKRGRPLKVRPFECSICKIKCSIYWRRILINEVRTSVCNACGLRTMKKTKKENIEKKKNKISNILNDHNSEIDNQIIIYLNQKKTTTTTTTTTTSSTNNLNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNNDNNNNDNNNNDNNNNNNNNNNNNNNNNNNNNNDNYNDSIYSRLYSDDYEDEYYEGEEYENEDE
What are the official names of this protein?
GATA zinc finger domain-containing protein 13.
Protein: MPRGB_DANRE
Sequence: MLSLIKLQRVFNVHQVPKAFHEDGIISGYRHPRSSATECVWSLFQLTNETLNVWTHFLPTWYFLWKLMTVLLMEDVWNEAYTWPLLVFLFSCCVYPLASSCAHTFSSMSTRARHICYFFDYGALSFYSLGSAISYSAYVFPDAWLSSSFHAYYISVAVFNTVLSTSLACYSRLGLPLLHYSHDIVERFSERQCPRMSKVLRILAFAYPYLFDNIPLFYRLFVCVGEGCTDNEANSVHVQHTLLAFLTSFLFATHLPERLAPGRFDYIGHSHQLFHVCAIIGTHFQMKAIEMDMGLRRSQLLASAPAISFNNTIGAALLCVSVSLGIICVYSLPLLYSSNPKNTANKE
What is the function of this protein?
Steroid membrane receptor.  Binds progesterone.  May be involved in oocyte maturation (By similarity).
What are the official names of this protein?
Membrane progestin receptor gamma-B, mPR gamma-B, Progestin and adipoQ receptor family member V-B.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMA_MANSM
Sequence: MQNLTNLSSRTYDQHFPKLSAEQLAENAKKKVIVGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDTDYCTAAADLADAQAVADKLGMKLHKINFAAEYWDNVFEHFLAEYKAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRRGDDENARLLRGLDSNKDQSYFLYTLSHKQVGQSLFPVGDIEKPIVRAIAEDLGLITAKKKDSTGICFIGERKFKDFLARFLPAQPGEIRTVDGKVIGRHDGLMYYTLGQRKGLGIGGIKGMDENPFYVAEKDLVNNVLIVAQGHDNSALLSSGLIARQLHWVDRQPIRENLRCTVKTRYRQTDIPCEIQPIDDETIRVIFDEPQIAVTPGQSAVFYQGEVCLGGGVIETQIK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR48_XENTR
Sequence: MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWNVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQMGTVIVSGSTEKVLRVWDPRTCQKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEGFTHVYSGGRDRKIYCTDLRNPDIRLLICEEKAPVLKMELDRSADPPLALWVATTKSSVNKWPIKGILNFRSSGDYENDCSTPLSPICSQPDQVIKGGASIIQCNILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEEEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEFWPRTHINPMEEEENEVNHVANGEQENRIQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHSSSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINVDTESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQILDPNMDLRTVKHFIWKSGGDLTLHYRQKST
What is the function of this protein?
Regulator of deubiquitinating complexes, which acts as a strong activator of usp1, usp12 and usp46.  Enhances the usp1-mediated deubiquitination of fancd2; usp1 being almost inactive by itself.  Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.  Also activates deubiquitinating activity of complexes containing usp12.  Together with rad51ap1, promotes DNA repair by stimulating rad51-mediated homologous recombination.  Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA).  DNA-binding is required both for usp1-mediated deubiquitination of fancd2 and stimulation of rad51-mediated homologous recombination: both wdr48/uaf1 and rad51ap1 have coordinated role in DNA-binding during these processes.  Together with atad5 and by regulating usp1 activity, has a role in pcna-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated pcna.  Together with atad5, has a role in recruiting rad51 to stalled forks during replication stress.
What are the official names of this protein?
WD repeat-containing protein 48, USP1-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR48 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Lysosome. Late endosome. Note=Mainly in cytoplasmic compartments.
Protein: MUTS2_CLOBA
Sequence: MNKRSLRVLEFNKVKEMLKKYAYSSSAKKLVDELVPYDNTYEINNRLEESNEALEILMKKGNPPIEGLCDIGDILQRAKKGGTLTPEQLLKVLGMLTATRRMQEFFKREDQEVSFPKLEDLAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSLKEKNSSVREKINSIVRSNSKYLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLKEKAEIDRVLSALSLKVKMNAEHCESNFKILTNLDFIFSKGKYACELNAIKPMVRDDGIFNIMSGRHPLIEKDKVVPLDVVLGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPASSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIMEYDNRQSLILFDELGGGTDPAEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKERVENASVEFDINTLRPTYRLLIGVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVIKDEADNLKKKYEQKLERLEKVKDKAYMDAREEAKKIVANAKDEADEILKAMRELEKLGIGSGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVALGMEAFLPSLNQTVVVISMPDNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEACYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGATIVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: ENO_BACLD
Sequence: MPYIVDVYAREVLDSRGNPTVEVEVYTESGAFGRALVPSGASTGEYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELIGFDVTEQVSIDKLLIELDGTENKGKLGANAILGVSMAVARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNVDIQEFMIMPVGAENFREALRMGAQIFHSLKSVLKEKGLNTAVGDEGGFAPNLGSNEEALQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLAGEGVVKTSAEMVDWYEELTSKYPIISIEDGLDENDWEGHKLLTERLGSKVQLVGDDLFVTNTKKLAEGIKNGVGNSILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPSRTDRVAKYNQLLRIEDQLAETAQYHGIQSFYNLNK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: IL12B_HUMAN
Sequence: MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS
What is the function of this protein?
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.  IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.  IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.  IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y816_BACLD
Sequence: MSDQKTAELNKMIEEISQKLNMLNIGVIKAEDFSNEKLEDLEYLHQMVMKKKSFSPSEMQAIAEELAALRK
What are the official names of this protein?
UPF0435 protein BLi00816/BL03111.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.