PharMolix/UniProtQA huggingface dataset:
Protein: MURA_TOLAT
Sequence: MDKFRVQGPTQLTGEVIISGAKNAALPILFAALLAEEPVEIQNVPKLRDIDTTMKLLSQLGARVERNGSVHVDAGPVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHINGLEQLGAKITLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMCAATLAEGKTIIENAAREPEIVDTANFLNTMGAKISGAGSDKIIIEGVKRLGGGVYRVLPDRIETGTFLVAAAVTGGKIVCRNTRPDTLDAVLAKLTDAGADIEVGEDWISLDMQGRRPKAVNIRTAPHPGFPTDMQAQFSLLNMVAEGTGVITETIFENRFMHIPELIRMGGHAEIESNTVICQGVARLSGAQVMATDLRASASLVIAGFVAQGTTIVDRIYHIDRGYESIEEKFRALGGQIDRIKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRVP_OXYSC
Sequence: MIAFTVLLSLAAVLQQSSGTVDFASESSNKKDYRKEIVDKHNDLRRSVKPTARNMLQMKWNSRAAQNAKRWANRCTFAHSPPYTRTVGKLRCGENIFMSSQPFAWSGVVQAWYDEVKKFVYGIGAKPPSSVIGHYTQVVWYKSHLLGCASAKCSSTKYLYVCQYCPAGNIIGSIATPYKSGPPCGDCPSACDNGLCTNPCKHNNDFSNCKALAKKSKCQTEWIKSKCPATCFCRTEII
What is the function of this protein?
Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents.  Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle (By similarity).
What are the official names of this protein?
Cysteine-rich venom protein pseudechetoxin-like, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS5_BIFLS
Sequence: MSDNETKETQVAEETQNTVATESNNEDRKGRRGQRGEGRRGERRNRREENHGDELLDRVVTINRVSKTHKGGRTFSFAALVVVGDGNGTVGVGYGKSREVPAAIAKGQLDAKKHMFSVPRVRGTITHPVQGHDAAGTVLLRPAAPGTGVIAGGSVRAVMECAGITDVLTKSMGSATAVNVVRATVDALKQLEEPEEIAARRGLALDEVAPDALLRARAAGIAEARKAREEAAAAKAAEEKDGE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PAX6_XENLA
Sequence: MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVNKIAHYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASDKQQMGSEGMYDKLRMLNGQTATWGSRPGWYPGTSVPGQPAQEGCQPQEGVGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSASVYQPIPQPTTPVSSFTSGSMLGRTDTALTNSYSALPPMPSFTMGNNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
What is the function of this protein?
May be a transcription factor with important functions in eye and nasal development.
What are the official names of this protein?
Paired box protein Pax-6.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLST2_ARATH
Sequence: MLGLQRETSSMYKRTSSRDYSPMIDVEDSSGLLENDVDNEMETTNPSWKCSLPHVLVATISSFLFGYHLGVVNEPLESISSDLGFSGDTLAEGLVVSVCLGGAFLGSLFSGGVADGFGRRRAFQICALPMILGAFVSGVSNSLAVMLLGRFLVGTGMGLGPPVAALYVTEVSPAFVRGTYGSFIQIATCLGLMAALFIGIPVHNITGWWRVCFWLSTIPAALLALGMFLCAESPQWLFKQGKIAEAEAEFERLLGGSHVKTAMAELYKLDLDKTDEPDVVSLSELLYGRHSRVVFIGSTLFALQQLSGINAVFYFSSTVFKSAGVPSDLGNIFVGVSNLLGSVIAMVLMDKVGRKLLLLWSFIGMAAAMALQVGATSSYLPHFSALCLSVGGTLVFVLTFALGAGPVPGLLLPEIFPSRIRAKAMAFCMSVHWVINFFVGLLFLRLLEKLGPRLLYSMFSTFCLMAVMFVKRNVIETKGKTLQEIEISLLAKP
What is the function of this protein?
May be involved in the efflux of glucose towards the cytosol.
What are the official names of this protein?
Probable plastidic glucose transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: NCAM1_RAT
Sequence: MLRTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEEAWHSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRALASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVETKSEPQESEAKPAPTEVKTVPNEATQTKENESKA
What is the function of this protein?
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
What are the official names of this protein?
Neural cell adhesion molecule 1, N-CAM-1, NCAM-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RBFA_CERSK
Sequence: MAHRSHTGTGPSQRQLRVGELIRRTLADVLNRGEIHDPELNRLSITVGEVRCSPDLKVATVHVMPLGGKDVEEAIALLSKHRGELRHHITRQMTLKYAPDLRFRPDETFDRLDETRRLFSDETVMRDIRGGGEADED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIP_BRUSU
Sequence: MTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAANFDTYLWRVARFTIWQAVASSLRSVLFAIPIARALYAEARFPGRGLILRLFALPLALPALVAVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAHIFFNMPLAVRLLLAAYESIPDDYWKLAAQLGMGSRARFRLIEWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTLEVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSEEGFTQTATPRRYGSPRKTERLFNIIVITLGFLYVALPIAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLAVFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGAGWFILLRHFTDPFVMAPLMVVTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAFAMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRAAASRKEAFLQ
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Thiamine transport system permease protein ThiP.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_LIGS1
Sequence: MYAIIKTGGKQLKVEAGQTIYVEKLDAKEGDKVTFDKVVFVGGDKTVIGTPFVEGATVEATVEKQGRAKKVVTFKYKPKKHQHTKQGHRQPYTKVVIDAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RF1_STRP8
Sequence: MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDQKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDIILSGKMDEVIDALVMYDQTKKLESLNN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_RHOBA
Sequence: MSRVVLAMSGGVDSSVAAHLLLRDGHEVIGVFMRHGEASAAACRIDSDEPQNTNPLNLPVLGDSAGGKRADHKQGCCSATDAADARRVAMSMGIPFYSLDLQEDFRKIVDYFVDDYLAARTPNPCVKCNHWIKFGRLFDYADGVDAEFVATGHYARMVHSNGRSELHRGLDGHKDQSYALFGIDPARLSRMMLPVGDFTKPEIREMATSLGLGVSDKKDSQEICFVTQGHHSDFVKSRRPEMVGATAGEIVTTGGKVVGEHKGFEAFTIGQRKRLGVAMGEPHFVIRIEPDTRRVVIGRAEELLRPGLVADQCNWFVTREELADAQSVGIQIRYNGQPHPGHVVMDGSDPTRMKVMFDDPQAAVAPGQAAVVYDGERVLGGGWITHAIDHIADGSPPPA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOH1B_HUMAN
Sequence: MGGSAPPDSSWRGSLKVSYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHETVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEDNSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYNISMKHPQEMKTYSLSFDSLFSAVKNFTEIASKFSERLQDFDKSNPILLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGDVKRQISVAAFTVQAAAETLSEVA
What is the function of this protein?
Exhibits a dipeptidyl-peptidase IV type activity.
What are the official names of this protein?
Putative N-acetylated-alpha-linked acidic dipeptidase, NAALADase, Cell growth-inhibiting gene 26 protein, Prostate-specific membrane antigen-like protein, Putative folate hydrolase 1B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_CHLCV
Sequence: MMSFEEEQLRDHAVVNLYRIGAIRFGDFILSDGKKTPIYVDMRLVISCPDVLQTIASLIWRLRPSFNSSLLCGVPYTALTLATCISLKYNISMVLRRKELKHPNQEDKIKVEGLFSPGQTCLVINDVIASGRSILDTAKALEDEGLNIRESLVFLDRQVGGADALKEAGIKLRSVFTLEELVKALLSKCQLSETDAAIARTLLETF
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: LIVB4_BRUAB
Sequence: MSLKVFLQAGVACAALSLAGAAGASAEPLKIALVETLSGPQASTGLLYRAAVLYQLGKINEAGGFNGEKIQILEYDNQGGPVGAADRVKAAIADGAQIIVQGSSSAVAGQITEDVRKYNLRNKGKEVLYLNLGAEALELTGSKCHFYHFRFSPNAAIRFKTVAQGMKDKGILGERAYSINQNYSWGVDVENTVVANAKEIGYEVVDKTLHEVNKIQDFSPYVAKIQAANVDTVFTGNWSNDLLLLMKAASGAGLKAKFATSFLDQPGNIGNAGAIAEGHIVSTPFNPEANGEASMAFAEDYKKVTGHYPSYVEPAAVFGLQLFGEALKNVKPGEGKINTTDIALAIENASVKTPMGDYSMRSDDHQAKFPMVVQEVSKKARIKADGTEYGFLPFKTFTGDESIDPVQESCSMKRPG
What is the function of this protein?
Component of an amino-acid transport system.
What are the official names of this protein?
Leu/Ile/Val-binding protein homolog 4.
What is the protein family that this protein belongs to?
Belongs to the leucine-binding protein family.
Protein: SEQA_ALIF1
Sequence: MKTIEVDEELYRFIASQTQHIGESASDILRRLLMQSSPSDLAVSAPVEVQKKGIVVSKDAGKEASVDRVKAVRTLLISDEFSALDKAIDRFLTVLSELYKIDSKAFSEATEVKGRTRVYFADNQETLIASGKTTKPREIVGTPFWVITNTNTNRKRHMVELLMERMGFQHDLTEKVCAAI
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCB_ECO24
Sequence: MFRRLLIATVVGILAAFAVAGFRHAMLLLEWLFLNNDSGSLVNAATNLSPWRRLLTPALGGLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGREGAMILLAALAASCFAQRFTPRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGTMMLASLGPVIISAVVALLVSNLINHSDALLYNVQLSVTVQARDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAPPWQLALGGLIVGLLSLFTPAVWGNGYSTVQSFLTAPPLLMIIAGIFLCKLCAVLASSGSGAPGGVFTPTLFIGLAIGMLYGRSLGLWFPDGEEITLLLGLTGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVIASVISRTLHRDSIYRQHTAQHS
What is the function of this protein?
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
Voltage-gated ClC-type chloride channel ClcB.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NIKB_STAAC
Sequence: MFIIKSMLYRLMQMIVVLFVISTLTFILMKLSPGNPVDKILHLDVAQVSTEQINATKDKLGLNDSLLVQWWHWMNHLLHFNLGKSFESKEPVTQILFNYAPITLLISFSTLVVSLCISIPLGIIAAKRFHKWTDKVIRVISTLSISLPAFFIGIILLFIVTNLMNIDSVILSQFILPVITLSLGMCAYIIRLVRSNLLMLLQSNIVQASRLRGMNERYILIHDLLKPTILPIIPLLGISLGSLIGGTVVIENLFDIPGIGYLLMDSIKSRDYPVIQGCVLFIGFFVVIINTIADLLTLLLDPKQRLQLGNPKIKTNTPLISESSDRHA
What is the function of this protein?
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Nickel import system permease protein NikB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYS_PICTO
Sequence: MIDIKLLRLNSEIFYKSCRDRGFDTRILDEFFELDNEWKENLKQLNNIKHDKNSITMEISRRIKSGDDINDLKLKVESLNIDIQRLEGRQNEIDVKRNEILRLIPNLLADDVPRCFGDENNRLVRYYGRARVFSDDVKYFIENSGSGDYEEIDYRPKSHVDLISELNLADIERAGKIAGARFYFLKNRLFKLELALINYAVDFLSQRGYTVLEPPFMINYKSMSGATDIETFKDTLYKIEGDDLYLIATAEHPIASMLQDEILMEDELPIRVSGVSPCFRREAGAHGKDTKGIFRVHQFNKIEQFVFCKPEDSWDFFDELVRNSEDIYKSLKIPYRVVNVCSGELGNLAAKKYDIEAWFPAQGKFREIVSASNDTDYQARSLNIKYRSRDGNRFVHTLNSTAIATERILVAIMENFQDRNGKVIKIPEVLIPYTGFSEIGGDDN
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_ANAPZ
Sequence: MGSIPEFSIRDLMEAGVHLGHKAGRWNPAMAPYIYGVHRYKDIHIIDLRKTAVLLRNALSVLYDVVHRRGRVLFVGTKVQASNVIAEEAARCGQYYVNHRWLGGMLTNWETVSSSIRRLLDFEKLLNDTDAKFTKKELLMFDKKREKLERSLGGIREMGGLPHILFVIDTNKEHIAIQEANKLKIPVVAVLDTNSDPRGVDYPIPGNDDSIRSIDFFCRAVSNTILEAIRSDLMSSGISVAGSVGQAKDGSVVDSGKGKSIAAHKGGGKASKGAAEVVAGGSVVSASGGEDAVVQE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RSXA_SALG2
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLIYLRTLAFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF3_STRPM
Sequence: MSLTEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKSGTFAKSDWMDIEKQRGISVTSSVMQFDYAGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRNIPVFTFINKLDRDGREPLELLEELEEVLGIASYPMNWPIGMGRAFEGLYDLHNKRLELYKGDERFASIEDGDQLFANNPFYEQVKEDIELLQEAGNVFSEQAILDGDLTPVFFGSALTNFGVQTFLDTFLEFAPEPHGHKTTEGNVVDPLAKDFSGFVFKIQANMDPKHRDRIAFVRIVSGEFERGMGVNLTRTGKGAKLSNVTQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSPKNVMKQKSFHKGIEQLVQEGAIQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAEVVMTPMGKKTVRWISEDDLDQRMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDVTLEEKM
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BACAA
Sequence: MRKYEIMYIIRPGVEEEAQKALVERFAGVLTNNGAEIINTKEWGKRRLAYEINDLREGFYMILNVNANAEAINEFDRLAKINEDILRHIVVKEEEK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: VATB2_CLOTE
Sequence: MRKEYLLLDRVQGPLVVLSEVEGVAYDEIVEIKIANGETKKGRVVQLQGDKAVIQVFESTTGMSLQNTTISFTGKPLEISLSREVLGREFNGIGEAIDGRGEIYSLKKYNVNGRPINPVARKYPRNFIQTGISSIDCLTTLIRGQKLPIFSGNGMPHNELAAQIIRQAKIGGGDGEEKFAVVFAAMGIKHDDKEFFRKKFEEAGVIDRLVMFTNLADDPIVERITTPRAALTTAEYLAFEEGMHILVIMTDITNYCEALRELSSSREEVPSRKGYPGYLYSDLASLYERAGMMEGKDGSITQLPILTMPNDDITHPIPDLTGYITEGQIVLSRDLSGKNIYPPVNILPSLSRLMKDGIGEGYTREDHAEVSNQLFASYSYVQDVISLSQVIGEDELSPVDKIYMEFGREFESKFLNQGFEDNRSIDETLDLAWEILSILPKSQLDRVSPEALEKHYRGDK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain 2, V-ATPase subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: ATPF2_PROM3
Sequence: MTSLLLFGAGGLFDFDATLPLMALQVVLLTFILNALFFRPVGRVVEEREVYVTTSRAEAKQKLAEAEKLELELKEQLKSARIAAQQLIQEAEKDSEQLYREALAIANADANAAREKARREIDAQRDSALTQLKGDAEKLGDLIVNRLLAAK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RIGI_MOUSE
Sequence: MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLEDEEVQYIQAEKNNKGPMEAASLFLQYLLKLQSEGWFQAFLDALYHAGYCGLCEAIESWDFQKIEKLEEHRLLLRRLEPEFKATVDPNDILSELSECLINQECEEIRQIRDTKGRMAGAEKMAECLIRSDKENWPKVLQLALEKDNSKFSELWIVDKGFKRAESKADEDDGAEASSIQIFIQEEPECQNLSQNPGPPSEASSNNLHSPLKPRNYQLELALPAKKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGYNIASISGATSDSVSVQHIIEDNDIIILTPQILVNNLNNGAIPSLSVFTLMIFDECHNTSKNHPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAALDASVIATVRDNVAELEQVVYKPQKISRKVASRTSNTFKCIISQLMKETEKLAKDVSEELGKLFQIQNREFGTQKYEQWIVGVHKACSVFQMADKEEESRVCKALFLYTSHLRKYNDALIISEDAQMTDALNYLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDLYLVLQEEYHLKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNRATGMTLPAQKCVLEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEKANMIKEKIMNESILRLQTWDEMKFGKTVHRIQVNEKLLRDSQHKPQPVPDKENKKLLCGKCKNFACYTADIRVVETSHYTVLGDAFKERFVCKPHPKPKIYDNFEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIVSGVQNRHSKWKDFHFERIQFDPAEMSV
What is the function of this protein?
Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines.  Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments.  The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms.  Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons.  Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length).  In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential.  Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity.  A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity.  Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Sendai virus (SeV), Rhabdoviridae and Flaviviridae.  It also detects rotavirus and orthoreovirus.  Also involved in antiviral signaling in response to viruses containing a dsDNA genome.  Detects dsRNA produced from non-self dsDNA by RNA polymerase III.  May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
What are the official names of this protein?
Antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, RNA sensor RIG-I, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RLR subfamily.
Protein: PURA_CAMJD
Sequence: MSKADIIVGIQWGDEGKGKVVDKLCENYDFVCRSAGGHNAGHTIWVNGVRYALHLMPSGVLHPRCINIIGNGVVVSPEVLIAEMAQFENLKGRLYISDRAHLNLKHHSLIDIAKEKLKGKNAIGTTGKGIGPSYADKINRTGHRVGELLEPQRLCEALIKDFEANKTFFEMLEIEIPSAEELLADLKRFNEILTPYITDTTRMLWKALDEDKRVLLEGAQGSMLDIDHGTYPYVTSSSTISAGALTGLGLNPKEAGNIIGIVKAYATRVGNGAFPTEDKGEDGEKIAQIGKEIGVSTGRKRRCGWFDAVAVRYTARLNGLDALSLMKLDVLDGFEKIKICRAYEYKGMEIDYIPSDLENVQPIYEEMDGWDKVFGIKDYDLLPENAKKYIARLEELAGVKVKYISTSPERDDTIIL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.