PharMolix/UniProtQA huggingface dataset:
Protein: TAOK3_CHICK
Sequence: MRKGVPKDPEIADLFYKDDPEEIFVGLHEIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDIIKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDMLEVHKKPLQEVEIAAITHGALQGLAYLHSHCKIHRDIKAGNILLTEPGQVKLADFGSASIVSPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWSDSFRGFVDYCLQKIPQERPSSADLLRHDFVRRDRPPRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLTESQEEEEDSEHGSNLSRKMDSLGSNHSIPSMSVSTGSQSSSVSSMQEVLDESSPELVMMHSDESTVNSTSSVVQKKDHVFIRDEVGHRDRRPEVRPTQSVQNQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAVMEKEAKTAAADEKKFQQQILAQQKKDMATFLESQKKQYKLCKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLSQQRLYYDKNCRFFKRKTMIKRHELEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHFMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKSEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRRDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKFLLERQEREIETFDMESLRMGFGNLVTLDYPKEDYR
What is the function of this protein?
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade.  Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade.  In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases.  Inhibits basal activity of MAPK8/JNK cascade (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase TAO3, Kinase from chicken, Thousand and one amino acid protein 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_META3
Sequence: MSKLNYKVETDPNKTARAMGRSLRISRKHTIEICREISGMKLDKAIAYLNRVIELKQVVPFKRHGKDVPHKKGKYGWTAGRFPQKASTQILSVLENAKKNAEYKGMNTEKLRIKHISSNKGFTIKRHMPRAFGRASPKNQETVHVQVILEEFY
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RT12_DICCI
Sequence: MITLNQIKDRKARGSKKKRKTLLTGYPQKKGFCVKVYVTKPKKPNSAIRKVAKVTIRLKNKRKNLIAYIPGFGPHNLQPLSTVLIKGGRCQDLPGVKYRLVRKHYDFQIAERFPRKNRRSKFSVKNEKLKAKKGTAVRIG
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: REV_HV1B9
Sequence: MAGRSGDSDEDLLKTVRLIKFLYQSNPPPSLEGTRQARRNRRRRWRERQRQIRSISERILGTFLGRFEEPVPLPLPPLEKLTLDCNEDCGTSGTQGVGSPQILVESPAILEPGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: PAT13_SOLTU
Sequence: MATTKSVLVLIFMILATTSSTFATLGEMVTVLSVDGGGIKGIIPGIILEFLEGQLQKMDNNADARLADYFDVIGGTSTGGLLTAMITTPNENNRPFAAAKDIVPFYFQHGPHIFNSSTGQFFGPKYDGKYLMQVPQEKLGETRVHQALTEVAISSFDIKTNKPVIFTKSNLAKSPELDAKMSDICYSTAAAPTYFPPHYFATNTSNGDKYEFNLVDGAVATVADPALLSVSVATRRAEEDPAFASIRSLNYKQLLLLSLGTGTNSEFDKTHTAQETAKWGALQWMLVIQQMTEAASSYMTDYYLSTVFQDLHSQNNYLRVQENALTGTTTKADDASEANMELLVQVGETLLKKPVSKDSPETYEEALKRFAKLLSDRKKLRANKASY
What is the function of this protein?
Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens.
What are the official names of this protein?
Patatin-13.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
What are the subcellular locations of this protein?
Vacuole.
Protein: RS12_NITMU
Sequence: MPTISQLVRKPRAAKPLKSKVPALGNSPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVSSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDTAGVKDRKQGRSKYGAKKPKSA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: KHSE_AGRRK
Sequence: MAVYTDITEDDLKWFLTEYDVGTLLSYKGIAEGVENSNFLLHTSRDPLILTLYEKRVEKNDLPFFLGLMQHLASRGLSCPLPLPRRDGELLGHLSGRPAALISFLEGMWLRKPEAKHCREVGKALAAMHVAGEGFDIKRPNALSLAGWQGLWEKSEARADEVEPGLQDEIRGELDFLGSHWPKDLPDGVIHADLFPDNVFFLGDELSGLIDFYFACNDQLAYDVSICLNAWCFEKDGAYNITKGMALLEGYQSVRPLSDAEIAALPTLSRGSALRFFLTRLYDWLTTPAGAMVTKKDPLEYLRKLRFHRQIASSAEYGLKA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: RL10_PSEPG
Sequence: MAIKLEDKKAIVAEVNEAAKVALSAVVADARGVTVSAMTGLRKEAREAGVYVRVVRNTLLKRAVEGTEFSILNDAFKGPTLIAFSNEHPGAAARLFKEFAKGQDKFEIKAAAFDGNFIAANQIDVLATLPTRDEAIARLMSVIQGATSKLARTLAAIRDQKEATAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RRF_CORA7
Sequence: MIDEIQLEAEEHMTASVEHTREQLLTIRTGRANPAMFNGLVAEYYGVPTPITQMATISVPEPRMLLIKPYEQSVMNEIENAIRNSDLGVNPTNDGQVLRVTIPQLTEERRRDMVKMAKSKGEDGKIAIRNIRRRAMEQLKKLQKDGDAGEDEVIAAEKEMEKITSGYIEQVDKLVANKEEELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CLOBA
Sequence: MKARELKELRSSNPQDLTVKLGDLKAELFNLRFQLATGQLENPMRIREVKKSIAQIKTILREDEMRALEQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MNMA_RICAE
Sequence: MINLGDKQSTIVVAMSGGVDSSAVAAMLHEQGHNVIGITLQLYDHGMAVGKKNACCAGQDIYDAKMVANKLGIPHYVLDYESKFKESVIDNFVDSYLQGETPLPCVQCNKSVKFRDLIKTARELGADKLATGHYVRKINGDNGAELHTGLDPAKDQSYFLFTTTKEQLEYLRFPLGGLTKDETRKLASKFGLEVADKPDSQDICFIPDGNYKSVINKIRPNSSESGKIIHVNGFELGEHSGIINYTIGQRRGLGIAYNEPLYVVKIDPKDNVVYVGPESALNVQEFIIRDVNWLADEIKDNEKLEVAVKIRSTRPPRLAEISKFGDDKMKVKFLCEEKAVAPGQACVIYAGARVLGGGWITREIR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLID_ECO57
Sequence: MASISSLGVGSGLDLSSILDSLTAAQKATLTPISNQQSSFTAKLSAYGTLKSALTTFQTANTALSKADLFSATSSTTAFSATTAGNAIAGKYTISVTHLAQAQTLTTRTTRDDTKTAIATSDSKLTIQQGGDKDPITIDISAANSSLSGIRDAINNAKAGVSASIINVGNGDYRLSVTSNDTGLDNAMTLSVSGDDALQSFMGYDASASSNGMEVSVAAQNAQLTVNNVAIENSSNTISDALENITLNLNDVTTGNQTLTITQDTSKAQTAIKDWVNAYNSLIDTFSSLTKYTAVDAGADSQSSSNGALLGDSTLRTIQTQLKSMLSNTVSSSSYKTLAQIGITTDPSDGKLELDADKLTAALKKDASGVGALIVGDGKKTGITTTIGSNLTSWLSTTGIIKAATDGVSKTLNKLTKDYNAASDRIDAQVARYKEQFTQLDVLMTSLNSTSSYLTQQFENNSNSK
What is the function of this protein?
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament.  Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
What are the official names of this protein?
Flagellar hook-associated protein 2, HAP2, Filament cap protein, Flagellar cap protein.
What is the protein family that this protein belongs to?
Belongs to the FliD family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: DCL2_NEOFI
Sequence: MASSVTACQGASPYQPRNYQLEMLEASMKENIIVAMDTGSGKTHIAVLRIKAELDICPPDKLVWFLAPTVALCIQQHEVIASNLPAVRTRTLTGLDKVELWTEQSIWDAVLNGYRVIVSTHAVLADALSHGFVKMSRLALLIFDEAHHCTRRHAANKIMRDFYHPTLTKSGPGAVPRIMGLTASPVVRSNHQELLTVESNLDAVCRTPRVHRQELVKFTHRPHLQQIWYTPTDPAGFKSASQTLGALYHAWETLDIGDDPYIQRLRKSPLDDTALKKALLTGKTYCREQLRRFVDRSRHIFEELGEWAAEYYIYASIKQLGDRVRNSYMSGDWDEAEKAYLVDFLSKIPASEIQLALNDPGSFRISPKFESLLNFLDSLDEREFSGLIFVKQRATVSAMTSLLSVHPCTRERFRCAAYVGWSNGSASKDILGDLLNMQLQRDTLDDFRSGRKNLIIATDVLEEGIDISACSVVVCYDKPPNLKSFVQRRGRARRKQSTFAIMFPTDDASADVSKWQDLEQAMIEAYQDDERQLQSVSALESLDEEVMERLTVESTSAVLTADMAMAHLHHFCAVLPPQPYADMRPVFSFETNEDGLLKGTVILPSCVHPKVRRTEGRRWWRTERAAMKETAFQAYKALYEFGLVNDHLLPLTKRPELKSHDLGAMPSILETSEQYDPWIEWAYSWSSPDIHQSRIVVRMNEGRGDELCMRLMGPTYLPPLSPMTLFWNNSTTFTVTFEAAERVPLVPLSSVEDMRAITALYLKATNSRVCSSERDFTALFAPDLHHTELKGWLNAYEGCDPAMEVYSRGHNPLLMGVVRDHSRYGEPFLFRKWLVSDQNPSCSVVELECAPFPHRRNLLHRQRLANSQVDVDEETPESAAKNPIVAADACTIDRLPFTMAIFGLFISAIVERLETELIATRLRETILRDVGFKSTDHIITAISTPFAHALTNYQRYEFLGDSILKFSVSCQLFFQHPNWHEGYLSEGRAMIVQNPRLAKAALDTGLDAYIVTKRIASRKWSAPLISEKLERVPAKRQMSTKVLADVVEALIGAAYMDGGHATAQACIRRLLPEINLHAVDTRTATRSVAPESARHMMNERLKDHIGYTFEDESLLVEALTHPSCDYDSTTQSYQRLEYLGDAVLDMVIVSAIFNHPIQRPQGDMTKIKHAVVNANLLAFLCMESATSEEKLDVAQTSKDSFAVTTSQESVELWRFMRYRGQNLNAARDASLARHRALRDEIASSLLHAPHYPWHALSRLNADKFFSDIVESVLGAIFVDSGGDLAPCEVFVERIGLMAYLRRILDQEIDVRHPRSVAQQLAKTNIQFVLQRVPNEEGGASYQCSVRIEQAELFVVTGCLTAEEAEVTAAVEAIKFLTRDEGSTPLNTS
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense response against viral infection and transposons (By similarity).
What are the official names of this protein?
Dicer-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: SDO1_PYRAB
Sequence: MPISVDKAVIARLKVHGETFEILVDPYLARDFKEGKEVPIEEILATPYVFKDAHKGDKASEKEMEKIFGTSDPYEVAKIILRKGEVQLTAQQRREMLEEKKRQIATIIHRHAVDPRTGYPHPVDRILRAMEEVGVRVDIFKDAEAQVQDVIKAIRRILPLRIEMKVIAVKIPSEYVGRAYGEVRKFGRIKKEEWASDGSWLFLIEIPGGVEEEFYEKLNALTKGNAQTKLIERKGL
What are the official names of this protein?
Ribosome maturation protein SDO1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SDO1/SBDS family.
Protein: ML12B_RAT
Sequence: MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGRINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
What is the function of this protein?
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation.  Phosphorylation triggers actin polymerization in vascular smooth muscle.  Implicated in cytokinesis, receptor capping, and cell locomotion.
What are the official names of this protein?
Myosin regulatory light chain 12B, Myosin RLC-B, Myosin regulatory light chain 2-B, smooth muscle isoform, MLC-2, Myosin regulatory light chain 20 kDa, MLC20, Myosin regulatory light chain MRLC2.
Protein: SUCB2_HUMAN
Sequence: MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
What is the function of this protein?
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial, GTP-specific succinyl-CoA synthetase subunit beta, G-SCS, GTPSCS, Succinyl-CoA synthetase beta-G chain, SCS-betaG.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LASR_PSEAE
Sequence: MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
What is the function of this protein?
Transcriptional activator of elastase structural gene (LasB).  Binds to the PAI autoinducer.
What are the official names of this protein?
Transcriptional activator protein LasR.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
Protein: NAS31_CAEEL
Sequence: MILQLLFYSLFTHLAVSQIDVNQALNQNKLNIDTISSSAISDAELEKTFPRTNLSRMRNALKSLRQNWSAKLQAMPARNYQNAGTNQENGATEQQKPLREKPRDRVKMEGDTLHQVNKAAGLNDILYQGDMVLTDDQIATILEARDETTVSTASRARRQAYRDRYYPSTTWGSSVYYYYDRTATPKIVKAFEQAVAFWQNVTCINIMQSSTAINRIRVFKGQGCYSYVGRISGVQDLSLGTGCEEFGTAAHELGHALGFFHTQSRYDRDNYISINYANIDPSYVEQFDKETSNTNFNYGMPYDYGSIMQYGATSASSNDKATMIARDTEYQDTMGSDFVGFYDISMMNEHYKCKELCPAASSAQCKNGGFPSPRNCAICICPSGYGGILCDQRPPGCGDSVTATTTWQTLTNTIGDGLPTLRDNHTMCNYWVKAPDNQAVEIRISGLTTVTIDGCIFGGVEIKTHKDQKLTGYRYCSSADQNTVHRSTGSLVPIILFNRYASTKAVLEYRAVTPSVDVSATYTTFAPIVNSCQDLHPNCDFYKFFGMCRSKKIRSNCKFTCHDCNNNNASPFGSNFFNNNYNSFNNWYTNKNKNYYPYSNSNNNKPWMWFF
What is the function of this protein?
Metalloprotease.
What are the official names of this protein?
Zinc metalloproteinase nas-31, Nematode astacin 31.
What are the subcellular locations of this protein?
Secreted.
Protein: SSN3_NEOFI
Sequence: MFGRNFPFFNSIGGFYPRESLDSKRPSGTGYTSKVRVRDKYHIVGFISSGTYGRVYKAIGKDGRKGEYAIKKFKPDKEGEIIQYTGLSQSAIREMALCSELDHPNVVQLAEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMIKSILFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAVRIGDLGLARLFYKPLNSLYSGDKVVVTIWYRAPELLMGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIIDIMGLPRKETWPGLVSMPEFSQLQSLAMSRGYLNRQCNLEGWYQSCLKNNGYSPGSAAGTPGAEGFDLLSRLLEYDPTKRISAREALEHPYFTTGTPVTANCFAGYEGKYPHRRVTQDDNDIRSGSLPGTKRSGLPDDSLMGRAAKRLKE
What is the function of this protein?
Component of the srb8-11 complex.  The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription.  The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase ssn3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS3_PIG
Sequence: MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA
What is the function of this protein?
Involved in translation as a component of the 40S small ribosomal subunit.  Has endonuclease activity and plays a role in repair of damaged DNA.  Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA.  Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS).  Has also been shown to bind with similar affinity to intact and damaged DNA.  Stimulates the N-glycosylase activity of the base excision protein OGG1.  Enhances the uracil excision activity of UNG1.  Also stimulates the cleavage of the phosphodiester backbone by APEX1.  When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage.  Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide.  Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes.  Represses its own translation by binding to its cognate mRNA.  Binds to and protects TP53/p53 from MDM2-mediated ubiquitination.  Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization.  Involved in induction of apoptosis through its role in activation of CASP8.  Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5.  Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
What are the official names of this protein?
40S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Mitochondrion inner membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis. Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide. Accumulates in the mitochondrion in response to increased ROS levels. Localizes to the spindle during mitosis. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: SLX4I_DANRE
Sequence: MEPSKFVVKCGNYAVLVDLHILALGDQDNANWFSPAHRKEVGSLIRDALEPRVRQFQEARYQKIQSKPRKDLTPTAPLCLEGGNVRLAVHFMKRHVNLRCIVRQHYRELRVFPERVVVCASPPENSALPNGNLNLDVSEQSQSKYFSNSGETANPLQSSTATKRAVLQKIARKTKIQPPRSQDNQESKTGQFQADNAEKGSRSVLQRITRQANIQPQQCQDDQVYKSGQFQADKQEKGSGDVLQKITRQANIQPQQCQDDQESKSGQVQADKEENGSGDVLHKIAKQTNTQPPQSQDDQEFKSGQFPAGESEKGSRSVLQEIARQANIQSPHSQEDQEFKSGQFQVAEECVEACLPVPISVSSIKSLVDVKALSSSKLSNNKDVTESYLDTTGPRRRPRAPSSSGEDADHQKTKRLRLGQSAVSSDSNNPSSGIAAPDSVCSPQPEISQTNQSGLATSLRGLSVKPVSSGSSISSRPAAREERKGGEPRTSRLRRLKKS
What are the official names of this protein?
Protein SLX4IP.
What is the protein family that this protein belongs to?
Belongs to the SLX4IP family.
Protein: RL21_RICPR
Sequence: MFAVIKAGGKQYKVDRNSVIKVEKIDGELGSKIQFDQILMIGEYSKPSFIGTPIVKGAIVTAEITNQLKDNKIIAFKKKRRKNYRRKAGHRQELTELKILDITKQ
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: AMPN_HAECO
Sequence: MTSQGRTRTLLNLTPIRLIVALFLVAAAVGLSIGLTYYFTRKAFDTSEKPGKDDTGGKDKDNSPSAAELLLPSNIKPLSYDLTIKTYLPGYVDFPPEKNLTFDGRVEISMVVIEPTKSIVLNSKKISVIPQECELVSGDKKLEIESVKEHPRLEKVEFLIKSQLEKDQQILLKVGYIGLISNSFGGIYQTTYTTPDGTPKIAAVSQNEPIDARRMVPCMDEPKYKANWTVTVIHPKGTKAVSNGIEVNGDGEISGDWITSKFLTTPRMSSYLLAVMVSEFEYIEGETKTGVRFRIWSRPEAKKMTQYALQSGIKCIEFYEDFFDIRFPLKKQDMIALPDFSAGAMENWGLITYRENSLLYDDRFYAPMNKQRIARIVAHELAHQWFGDLVTMKWWDNLWLNEGFARFTEFIGAGQITQDDARMRNYFLIDVLERALKADSVASSHPLSFRIDKAAEVEEAFDDITYAKGASVLTMLRALIGEEKHKHAVSQYLKKFSYSNAEATDLWAVFDEVVTDVEGPDGKPMKTTEFASQWTTQMGFPVISVAEFNSTTLKLTQSRYEANKDAVEKEKYRHPKYGFKWDIPLWYQEGDKKEIKRTWLRRDEPLYLHVSDAGAPFVVNADRYGFYRQNHDANGWKKIIKQLKDNHEVYSPRTRNAIISDAFAAAATDAIEYETVFELLNYAEKETEYLPLEIAMSGISSILKYFGTEPEAKPAQTYMMNILKPMYEKSSIDFIANNYRNDKLFFQINLQKDVIDMFCALGSQDCRKKYKKLFDDEVMNKCRDGQAATECVRIAAPLRSSVYCYGVKEGGDYASDKVMELYTAETLALEKDFLRLALGCHKDVTALKGLLLRALDRNSSFVRMQDIPSAFNDVAANPIGGEFIFNFLIERWPDIIESIGTKHTYVEKVIPACTSGIRSQQQIDQLKNLQKNGMNARQFGAFDKAIERAQNRVDWIKKHFQKLAAFFKKATL
What are the official names of this protein?
Aminopeptidase N, AP-N, Membrane glycoprotein H11, Microsomal aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: LGT_SYNY3
Sequence: MIEQIFFGQFQSPGPVMFQIGGFALRWYGFLIASAVIIGLNLCQWLGQKRGINPDLFNDLVIWLVVAAIPSARLYYVAFEWPRYAQHWLNIFAIWQGGIAIHGALIGGTIAILVFSRYHQLSFWNLLDVLTPAVILGQAIGRWGNFFNSEAFGAPTNLPWKLYIPFANRPLNLTSYAYFHPTFLYESVWNLGIFAILIALFFYGLRNPEKIKTGTITCVYLIGYSLGRVWIEGLRLDSLMLGPLRIAQVVSITLVLLGTAGIVWLYLLQKNLPDWSERKLVKN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.