PharMolix/UniProtQA huggingface dataset:
Protein: COBS_FRACC
Sequence: MMLEARTAFTLLTVLPLRGPEHTDRRLAGRAMALAPFVGLALGLLAGSAVFATRIVTAVPGQRAQTLLPAVVGVTVLALVTRGLHLDGLADLGDGLGAWRARGRDRALEIMRESTIGAFGAIIVLFVVLLQVGALSTTISAHRGTLSILVAAMTSRLAATLACTGAVPPARPDGLGALVAGTVRTRDAALSFLAVCAVAALAGLLDFDGGGPGRALRAVLAVWVGTGVSFLLRRYLLTRFGGITGDILGGLIEITAAATLLVMAMTIPTPVLHTLGLH
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PNP_HELP2
Sequence: MDFITINSSNKTEEFALKQVAKQATSSLMYRLGKTIILASVCVEREPVSEDFLPLVVQFLEKSYAAGKIPGGFVKREGRAQDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIENDLQVSALNAASAALFLAHIAPIKSVSACRIARIDNEFIINPNTSLLNQSSLDLFVSGTKESLNMIEMRSLGQKLNALEEPLMLEALELAQKSLKETCTLYEEVFTPHQNELLFKESQAIVLNERLLDLLTNQYFDEIIKGIESSALSERENVFNEIAKKISEAHSEFSLEEIEWSLEKVKKTEIRRMIIQDKIRPDKRALEEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDNDAQTHESLEHKTPIKERFMFHYNFPPFCVGEASSIGAASRRELGHGNLAKRALETSIKNKEQVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDISGLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEAREHILKIMHEAKEKIVINFSHLPTTEIFNVAPDKIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKERVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFGAFLSLPKGGEGLLRKQNMDRCQVVLKEGDSIKCRVISFNKGKIALDLA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_RALSO
Sequence: MSLDLDQVVADAQTAFASVEDNASLENEKARFLGKSGVLTDLLKGLGKLDPQTRKSEGARINLAKSRVEAALNDRRQALADALMNARLAAEAIDVTLPGRDVAEGSLHPVMNTWERVAQIFGSIGFDVADGPEIETDWMNFTALNNPDNHPARSMQDTFYIDGRDSDDKLLLLRTHTSPMQVRYARMHVEKYKHLDRIPPIKVIAPGRTYRVDSDATHSPMFHQVEGLWIADNISFADLKGVYTDFLRKFFESDDIQVRFRPSYFPFTEPSAEIDMAFGNGRWLEISGSGQVHPTVVRNMGLDPERYIGFAFGSGLERLTMLRYGINDLRLFFEGDVRFLRQFA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHIA_ARATH
Sequence: MTNMTLRKHVIYFLFFISCSLSKPSDASRGGIAIYWGQNGNEGNLSATCATGRYAYVNVAFLVKFGNGQTPELNLAGHCNPAANTCTHFGSQVKDCQSRGIKVMLSLGGGIGNYSIGSREDAKVIADYLWNNFLGGKSSSRPLGDAVLDGIDFNIELGSPQHWDDLARTLSKFSHRGRKIYLTGAPQCPFPDRLMGSALNTKRFDYVWIQFYNNPPCSYSSGNTQNLFDSWNKWTTSIAAQKFFLGLPAAPEAAGSGYIPPDVLTSQILPTLKKSRKYGGVMLWSKFWDDKNGYSSSILASV
What is the function of this protein?
This protein functions as a defense against chitin containing fungal pathogens.
What are the official names of this protein?
Acidic endochitinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=Intercellular space of infected plants.
Protein: CAPSD_SHMV
Sequence: MAYSIPTPSQLVYFTENYADYIPFVNRLINARSNSFQTQSGRDELREILIKSQVSVVSPISRFPAEPAYYIYLRDPSISTVYTALLQSTDTRNRVIEVENSTNVTTAEQLNAVRRTDDASTAIHNNLEQLLSLLTNGTGVFNRTSFESASGLTWLVTTTPRTA
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RR20_PHATC
Sequence: MANNKSAQKRIQVNERNRLQNRFYKSSVRTLIKVFLKNLEIYKTSKSPEGKEKLQKILSSVYSLIDKGTKKNVFHKNAAARKKAKLASSLKIS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL3_THEP1
Sequence: MKMIIGRKIGMTRVFVGNDSVPVTVIKAGPCVVVQKKTVEKDGYNAVQLGFEKAKKVNKPLAGHFKKFGVEPMKILREFRVENPDEYEPGQVIKVDVFEKGEYVDVTGWTKGRGFAGAMKRWGFSGGPKSHGSKFHRELGSVGQHTEPAKIWKGKKMPGRYGNERVTVRNLQVVDIDPENDLLVVKGGVPGARGGLVLIRSAKAPKK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PTMS_PENSI
Sequence: MTQTRKLVTVYGATGNQGRSVVKSLLRAPDSFEVRAITRDPNSVAAQELSILGANLVQADGSQSNQMTEAFQGSWAVFLNINSDDPVFWDPKGPTEFDYGKRIIDSAIVAGVKTLVYSTGAACTELTKGTVSLRHLDTKNQIEMYARSTGAFENLVPIIPGYFLENFLFKQGAFIMGGFPWETDAEGYLTWKVPYWGGEEQIPFLSVADDFGDIVHGILISPSEYHLQVVQAMSEITDYQKMTEAFAKVTGKKTRFQPVLPTWKAFDASGNQGFEDVKSMFGFTQETQGHYFGREATDDQVSKNLKASAVLDYKESQQSPSLKTVRAWFAREFAA
What is the function of this protein?
NmrA-like family domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
NmrA-like family domain-containing oxidoreductase ptmS, Penitrem biosynthesis cluster 1 protein S.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: PRMA_SALRD
Sequence: MDTIELTLTIPPVEHAPFLAELEEPATGFVQNDTELRAYVPAERWAAVDQKQLKARLAADGHPDALSIRPLESKNWNAVWEDTLSPVRAGPFLVCPTSVAPPSARDDATVLRIDPEMSFGTGHHATTRLALRLLAEALAPGDRVLDVGTGTGVLAIAACRIGADAARGVDTNPDAVRNARENVRRNEETDCVTVQEGSVDVASDTQYDLVAANITRRVLLELMPALVARLAPGASLLLSGLLRPQRDDIRDAVASHGLALDAEAAEEGWWAGRFARSPSP
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCME_PSEAE
Sequence: MNPVRKKRLIIVLAIVAGVGAAVGLALSALQQNINLFYTPTQIANGEAPTDTRIRAGGLVEKGSLQRSEDSLNVRFVVTDGAKEVTIAYHGILPDLFREGQGIVALGKLGGDGVLVADEVLAKHDENYMPPEVTKALKDSGQLKHYENGKAAGETSYNQEGK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SMO22_ARATH
Sequence: MASFVESGWQYLVTHFSDFQLACIGSFLLHESVFFLSGLPFIFLERQGFLSKYKIQTKNNTPAAQGKCITRLLLYHFSVNLPLMLASYPVFRAMGMRSSFPLPSWKEVSAQILFYFIIEDFVFYWGHRILHSKWLYKNVHSVHHEYATPFGLTSEYAHPAEILFLGFATIVGPALTGPHLITLWLWMVLRVLETVEAHCGYHFPWSLSNFLPLYGGADFHDYHHRLLYTKSGNYSSTFVYMDWIFGTDKGYRRLKTLKENGDMKQT
What is the function of this protein?
Non-heme iron oxygenase involved in sterols biosynthesis by catalyzing the removal of the second methyl group at the C-4 position (PubMed:11707264).  24-ethylidenelophenol and 24-ethyllophenol are the preferred substrates (PubMed:11707264).  Together with SMO2-1, required during embryogenesis, probably by maintaining sterols and auxin homeostasis (PubMed:27006488).
What are the official names of this protein?
Methylsterol monooxygenase 2-2, Sterol 4-alpha-methyl-oxidase 1, AtSMO1, Sterol 4-alpha-methyl-oxidase 2-2.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: STA31_XENLA
Sequence: MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAFAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEEGRLLQTAAAAAQQGGPASHPNAAVVTEKQQMLEQHLQDVRKKVQDLEQKMKVVENLQDDFDFNYKTLKSQSDLSELNGNNQSVTRQKMQQLEQMLTALDQLRRTIISDLASLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQIRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTNKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGITFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHQEPTDPGSTAPYLKTKFICVTPTTCSSTLDLPMSPRTLDSLMQFPGEGADSSAGNQFETLTFDMELTSECASSPM
What is the function of this protein?
Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation.  Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling.  Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differentiation.  Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk. 2.
What are the official names of this protein?
Signal transducer and activator of transcription 3.1, Protein Stat3, Xstat3.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation (By similarity).
Protein: MSRQ_SALPA
Sequence: MRLTVKQITWLKVCLHLAGFLPLLWLFWAINHGGLSADPVKDIQHFTGRTALKFLLATLLVSPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLVLLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPIHYLWSVKILSPQPVIYAALALALLALRYRKFRQWWR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NIR_RHISU
Sequence: MTNTLQMTRRTMLTGAAVAGALTPILTSGGGNASPTPVRKLSATEIAALPRRKLDLVKPPFVHVHTQKAEGGPKVVEVTLTIEEKKLVIDGKGTEVNAMTFDGSVPGPLIVVHQDDYVEVTLVNPETNTLQHNIDFHSATGALGGGALTVVNPGESAVLRFKATKAGVFVYHCAPPGMVPWHVTSGMNGAIMVLPREGLTDGHGKELVYDKVYYLGEQDFYIPRDEKGEFKKYDSPGEAYEDTVAVMRTLTPTHIVFNGAVGALTGENALTAAVGERVLIVHSQANRDTRPHLIGGHGEYVWRTGKFVNVPDRDQETWFIPGPTRGAAYYTFEQPGIYAYVNHNLIEAFELGAAAHFKVTGDWNDDLMTTVRSPSGS
What are the official names of this protein?
Copper-containing nitrite reductase, Cu-NIR.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VDAC1_MOUSE
Sequence: MCSFFLVLLLWQNMAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVNGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETSKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQVDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane and also the plasma membrane.  The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis.  It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective.  Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity).  In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033).  May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:10716730, PubMed:15477379, PubMed:18988731).  May mediate ATP export from cells (By similarity).
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 1, VDAC-1, mVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Voltage-dependent anion-selective channel protein 5, VDAC-5, mVDAC5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
[Isoform Mt-VDAC1]: Mitochondrion outer membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform Pl-VDAC1]: Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: YR597_MIMIV
Sequence: MSVNDNINHNKKLLEKYVIEDDLYNFTQLINEVSCDDEFGYKLTTIATQEASINIIKYVFDTDIIKCFPKHQMLRYAVGLPSLGYFTKNKDEFHNSLELMKLLLQYDMNNNDFPISEYLYNAVKQNNFEKVKLLIDNGINSLKIISRYHFENKYIYNNHEIVKYMIDNGVDIQGFNLSYALHSCIISDNNDGVEYYFNIGANINDLDLESVVTIIKYNRIQKLFDYSYNFNKLDYLLDNEENNNYDEALNMLVELTSIKTKNVCVLLSLIMSKY
What are the official names of this protein?
Putative ankyrin repeat protein R597.
Protein: GATC_DESPS
Sequence: MKISEKEVQHVAHLSRLHLDQDELASMTEQLDGILSYMEKLAEVDTEGVLPTTHAFSKTNAFREDIVKDSLSQEESLANGPVQNGTAFQVPRVI
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: NUON_RICFE
Sequence: MLLLLPEITLTLIALLGQFFAVIIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFATGINIGISKSIVLLFTIISMIIYRDYSILIAEELKFEFITLILLSVVGIFVAISSRNFLLLFCGMELTALTSYALAGFKLNDIKSSEGALKYFILGSLVSCLSLFGISFIYGFGGSLQFEDILYKLNNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASKIGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLYILIYAVGSIGFFTCLIMLLGKDADKASFKTIQGIAENHKTIAAIISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFILAYCGIFTSVVAAFYYLKVVKAMYFSKKIEIIKLPMLYGLLLINYLVVGFLLLGSFIISF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ELP6_YEAST
Sequence: MGSVQRQDLVLFSDQSVLPAHFFQDSNSHNLFFITHQSCTQPLWMINALVETHVLGSPSSLNESSSSMLPSSTRSHAVLASFIHEQNYFTNSLNKLKIPSNNYNVLDFLSDFIVNNIHNKPRDKILSDVLAKFSAAIQNNPTDTIVIIEQPELLLSLVSGLTCSELNNKFITPLLRQCKVLIIVSNSDIFNIDEYDASVHSSNLQNFYKSSFIKSMINLNLNPLKTGFAKDVTGSLHVCRGGAPIATSNTSLHVVENEYLYLNEKESTKLFYR
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837).  The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).  It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232).  May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368).
What are the official names of this protein?
Elongator complex protein 6, Gamma-toxin target 6, HAT-associated protein 3.
What is the protein family that this protein belongs to?
Belongs to the ELP6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZMY15_MOUSE
Sequence: MEFVSGYRDEFLDFAALLFGWFRKFVAERGTMGTSLEGRWRQLESQIRRLPQDPALWVLHVLPNRSVGISLGQGAEPGPGPGLGASRLLGDEPPLHLRDLSPYVSFVSLEDGEEGEEEEEDEEHGERPGMEKVEPQEGGEPAPPSKRFPQEAKPAPESEVTQQEASREEGSREERPEDERAPEKRKGQKNAEAAPLHLSCLLLVTDEHGTILGIDLLMDGAQGSVGQNPGTENLAPRAYALLCHSMACPMGSGDPRKPRQLTVGDAHLHRELESLVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHKHSFEVKLTPCPQCSAVLYCGEACLQADWRRCPDDVSHRFWCPRLSAFMERVGELASLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGAPRYPWGSTSSLSCLLNGDPYQLLQGDGPALMPPVPLEPPRSLFGSWQDYYTWRGLSLDSPMAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDSLPPESDQQHFTMQRDGPEVSLRPGSGVSARFNSGTKEKGGRRDLQIRVSARPYHLLQGPKPDLVIGFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGCVMDDQTMAVATGGGTSSPQPNPFRSPFRLRAADNCMPWYCNAFIFHLVYKPPQGGTVRSAPGPAPRPPTPAAPPVPARRRRGEKKAARGPRRRR
What is the function of this protein?
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs).  May regulate haploid genes important for spermiogenesis.
What are the official names of this protein?
Zinc finger MYND domain-containing protein 15.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In step 9-11 spermatids, shifts from nucleus to cytoplasm.
Protein: PEB1_DROME
Sequence: MVRQLILVLSLILFCGSSHAVVSELARQSESAIQGLADIKMAPLRYLDVLFGGNPGGLRGLDGGNSASLSTLQAAKVANILARGDIASSGYSKISAGVGKGSDLITIIKNTRSYDPYLIPPGIPGYNYPLGWPLRYPLGPYWPNRPPWLPINSPPIRPGGLFPGGPSPGGPSPGEPSPGEPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPFPGGSPPSPGGPLGPWQFPWILGGPRPNRPGRPFPGGILPGHLDGSVVPNSVLNVAGGIFGNGGLFGTGIFGQHGLFGTGFLSGPSLDPFGIFTPIGNFFGSLGNLFGFSSPSQIIPIFGGKFGPLGRGLQGSITLDVGGTVPSVKGILGQLLHPFLGFLG
What is the function of this protein?
Major protein component of the posterior mating plug.  Accessory gland proteins constitute, or are required for formation of the anterior mating plug.  Posterior mating plug forms before sperm transfer and the anterior mating plug is formed after the start of mating.
What are the official names of this protein?
Ejaculatory bulb-specific protein 1, Ejaculatory bulb-specific protein I, PEB-me.
What are the subcellular locations of this protein?
Secreted.
Protein: ERPA_SHESR
Sequence: MTDQADAAMPIKFTDAAAAKVKGLLEEEQNPALKLRVYVTGGGCSGFQYGFTFDEKVNEGDFTVEKQGVQLVVDPMSLQYLVGGEVDYTSGLEGSRFFVKNPNATTTCGCGASFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: Y127_MYCGE
Sequence: MKKAGKKNSDAGKTFILISSSCSSCQKAIEFFDQNKISYVVENFYKKPISDKRFKDILSLSEDGTESLFSKRADQIKATNSVSVEELSISELIKLVRERPSLLRRPIIIQYNSSGIPKRMRIGYNSSEIKVFERKLIEPKPIIQQ
What are the official names of this protein?
Uncharacterized protein MG127.
What is the protein family that this protein belongs to?
Belongs to the ArsC family.
Protein: RRF_SHEPC
Sequence: MIENIKKDAQERMGKCVDATKNQMAKVRTGRAHPSLLDSIQVSYYGTMTPLNQVANVGVEDSRTLSVTVFDRSAIQAVEKAIMSSDLGLNPMSAGATLRIPLPALTEERRKDFIKVVRAEAEGGRVAIRNVRRDAISEVKKLEKAKECTEDDVRRFEDDVQKFTDAHIKKVDEILAAKEIELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAT_LACPL
Sequence: MQTVYGIKAHGGKLVNLEDFSEATRQAAEQLPSLTINNWNISDLELIGIGGFSPLTGFMVSDDYHSVVNTMHLKSGVIWSVPITLGVSQADADKIELNTKIALKGADGVIYGTMQVEDKFVPDKQLEAQNVYKTTDEAHPGVKRLYANGDVYLGGAIKLLHKPDHGAFSDYYMEPLETRKMFHDLGWKRIVGFQTRNPIHRAHEYIQKLALENVDGLFLNPLVGETKADDIPADVRMESYKTILKYYYPEDRVRLVIYPAAMRYAGPKEAILHAIVRKNYGCTDFIVGRDHAGVGDYYGTYEAQELITSVEDEMGMHFFKFDNSFYCKKCGSMATQKTCPHGAEDHISLSGTKVRKMLADGVVPPKEVSRPEVARVLIDGLKRKREQQQEV
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.