PharMolix/UniProtQA huggingface dataset:
Protein: NAPA_SHEHH
Sequence: MSISRREFLKANAAVAAATAVGATLPVKIVEAAEQKDNIKWDKAPCRFCGVGCSVLVGTDNGKVVATKGDPESPVNKGLNCIKGYFLSKIMYGKDRLTTPLLRMKDGQYDKEGEFTPISWDSAFDIMADKWKDTLKTKGPTAVGMFGSGQWTVWEGYAASKLHKAGFLTNNIDPNARHCMASAVGGFMRTFGIDEPMGCYDDLEAADQFVLWGANMAEMHPILWARLSDRRLSSPTSRVHVLSTYENRSFDLADNAMVFRPQSDLVILNYVANYIIQNDAVNKDFVNKHTKFALGTTDIGYGLRPDHPLEKKAKNPGNGKSKPISFDEYAKFVSSYTLEYAAEMSGVEPEKLELMAKAYADPNVKMMSLWTMGINQHTRGVWANNMLYNIHLLTGKIATPGNSPFSLTGQPSACGTAREVGTFAHRLPADMVVANPKHREITEKLWQVPAGTIPPKPGFHAVLQSRMLKDGKLNCYWTMCTNNMQAGPNINDEMYPGFRNPENFIVVSDPYPTVTAMAADLILPTAMWVEKEGAYGNAERRTHMWHQQVKAPEGAKSDLWQLMEFSKRFKVSEVWPAELIAKQPELADKTLFDVLYANGVVDKFPSSECKGQYNDEADAFGFYVQKGLFEEYAQFGRGHAHDLADFDTYHETRGLRWPVVDGKETLRRFSKGDPYVKGDKEFDFYGKPDGKAVIFALPFEPAAEEPNEEYDIWLSTGRVLEHWHTGSMTARVPELYRAYPDAQIFMHPEDAKARGLKRGDEVIVASPRGEVKTRVETKGRNKPPRGVAFMPFFDARQLVNKLILDATDPLSKETDFKKCPVKVMKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: GATC_BURA4
Sequence: MALTLTDVKRIAHLARLEMADADAEHMLGQLNEFFGLVEQMQAVDTAGIAPLAHPIEQIQEVAQRLRDDAVTEVVNRDDNQRPAPAVQDGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RL7_CAMJ8
Sequence: MAISKEDVLEYISNLSVLELSELVKEFEEKFGVSAAPVMVAGGAAAGGAAAAAEEKTEFDIVLTDGGAKKIEVIKIVRALTGLGLKEAKDAVEQTPSTLKEGVAKAEAEEAKKQLEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PARG2_ARATH
Sequence: MELRADLRSILQYLPLVAQSSSLVWPPSVEEELQTISRGPSESMVNSGEALALHITNMRKSLSLNASDLAPYALQGYGLFFDKKISREESANFFGEVVPALCRLLLQLPSMLEKHYQKADHVLDGVKSGLRLLGPQEAGIVLLSQELIAALLACSFFCLFPEVDRSLKNLQGINFSGLFSFPYMRHCTKQENKIKCLIHYFGRICRWMPTGFVSFERKILPLEYHPHFVSYPKADSWANSVTPLCSIEIHTSGAIEDQPCEALEVDFADEYFGGLTLSYDTLQEEIRFVINPELIAGMIFLPRMDANEAIEIVGVERFSGYTGYGPSFQYAGDYTDNKDLDIFRRRKTRVIAIDAMPDPGMGQYKLDALIREVNKAFSGYMHQCKYNIDVKHDPEASSSHVPLTSDSASQVIESSHRWCIDHEEKKIGVATGNWGCGVFGGDPELKIMLQWLAISQSGRPFMSYYTFGLQALQNLNQVIEMVALQEMTVGDLWKKLVEYSSERLSRRTWLGFFSWLMTSLST
What is the function of this protein?
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase.
What are the official names of this protein?
Probable poly(ADP-ribose) glycohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the poly(ADP-ribose) glycohydrolase family.
Protein: PEPT_STRPB
Sequence: MKYDNLLDRFIKYVKVNTRSDPDSETTPSTESQEAFALTILKPEMEAIGLQDVHYNPVNGYLIGTLPANNPTLTRKIGFIAHMDTADFNAENVNPQIIDNYQGGDITLGSSNYKLDPKAFPNLNNYIGQTLITTDGTTLLGADDKSGIAEIMTAIEFLTSQPQIEHCDIKVAFGPDEEIGVGADKFEVADFEVDFAYTMDGGPLGELQYETFSAAALEVTFLGRNVHPGTAKDQMINALELAIDFHEKLPAKERPEYTDGYQGFYHLTGLTGTVEEARASYIIRDFEEASFEARKVKVENIAQSMNAHLGTKRVLVELNDQYYNMKKVIEKDMTAIELAKEVMEELAIKPVIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEFVSLQTMERAVDVIIGLVCKA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_EHRCJ
Sequence: MSFDSNLEELYQKFCKLKSILEDPSQLSVDSFVAASKEYSELLPVISVIDQYNSLQKDIADLEELINNPETDHELKSLAKEEFYERQKQLPKIKNKLKLSLIPKDRDDARNAILEIRAGTGGEEAALFVTDLYRMYTKYAEQKNWKFEQINSSSTGIGGHKEVSLCISGSNVFARLKFESGVHRVQRVPETEASGRLHTSAATVAVLPEIEEVDLKIDEKDLRIDVYRSSGPGGQSVNTTDSAVRITHIPSGIVVIQQDEKSQHKNKNKALKVLRARLYNLEKQKRDSEISQMRKSQIGSGDRSERIRTYNFPQSRITDHRINLTLYRLEDIMKEGNLDEFIDALIAEDEANKLKNLHI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2A2_WHEAT
Sequence: MDGSKAKKVAAKKFGGPRKKSVTKSIKAGLQFPVGRIGRYLKKGRYAQRVGSGAPVYLAAVLEYLAAEVLELAGNAAKDNKKTRIVPRHLLLAIRNDQELGRLLSGVTIAHGGVIPNINPVLLPKKAAEKAEKAGAAPKSPKKTTKSPKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.2.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ATOX1_BACCR
Sequence: MKYPYSFEVLTNGKLVMRLPQEIKLMETFLGVEVSAFGDWILEEIHSVLNGKENYVVVNGNICGLEIRKDTTTVLDNLAEDGKGDFCEIETIELVDLIHIWQDKQKEFKKGKNKELK
What is the function of this protein?
Immunity component of an LXG toxin-immunity module.  Neutralizes the RNase activity of cognate toxin BC_0920.  Probably does not have immunity protein activity on other toxins with the LXG domain.
What are the official names of this protein?
Immunity protein BC_0921.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUC4_FUSSX
Sequence: MGQSQDNTQLTTASPQAEKDLSSNDNPPESEPAAPKKGARFWLVFIAIALTTFLAALDTSIISTALPTITSDLGSNSLYVWIVDSYLLASTATIPIFAQAANIYGRRSLTLIAVCLFTLGSGLCGGAHNTAMMIGGRSVQGVGGGGILTMSEIVVCDMVSVRERGMYAGIIGGVWAIASVIAPIMGGAFAQNVSWRWIFYINLPIAGVVLVALIVFLKLARPPTGTFKEQMSRIDWGGSVLLIASVTAVVLALSWGGSEHPWSSWRTLVPLILGLVGQLAFFAYQGAPWLKEPTMPLRLFGNRTSSTLFVISFVHSMLLFWVCYFLPVYFQAVKEASPARSAVMLFPIATTSAPGGVIAGIFITKTGKYRVWHFVGFALMSISCGLFTLLDDKSSIGRWVGFQLLFGFGTGFVFTSCLPPILASLPDSDVATATGAWTFLRNFGSIWGIAIPAAAFNTRVNSSLDKVSSGTVRDMLVNGGAYEHATKTFIQAFNNTPRLKAEIVQVYMDGLKLVWQVSIAFSVLGFVLAFLVKSLTLRDELNTEYGLEEKDTSKEKSSEEGNAS
What is the function of this protein?
MFS-type efflux pump; part of the gene cluster that mediates the biosynthesis of the mycotoxin lucilactaene and the lucilactaene-related compound NG-391 that act as cell cycle inhibitors with potent growth inhibitory activity against malarial parasites, moderate growth inhibitory activity against cancer cells, and no activity against bacteria and fungi.
What are the official names of this protein?
MFS-type efflux pump LUC4, Lucilactaene biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SHH_PSEPR
Sequence: VMNQWPGVNLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.  Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes.  Displays floor plate-inducing activity.  Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.  In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).
What are the official names of this protein?
Sonic hedgehog protein, SHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Secreted. Cell membrane. Note=Sonic hedgehog protein C-product: Secreted, extracellular space. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor. The C-terminal peptide diffuses from the cell, while the N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside.
Protein: UVRC_FRASN
Sequence: MADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHMVTTAGSVEWTVVSTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVMRGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVFKRAGQVGRPCLLGYIDRCSAPCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGALRRAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADLVEQFLTQEYLDGVRPAGTAGTADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLERARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRAGDLTARSRALADLQEALELPDAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRRFSRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALDELGIESGPGGVALCGLAKRLEEVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHRQKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAGAEEIAQVPGIGPRTAEAIVAALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGA_VIBA3
Sequence: MKLRSTALVKGFRQSTPYVNAHRGKTMVIMLGGEAVADRNFGNIISDIALLHSLGVKIVLVHGARPQINQLLEKQDCHTPYHKNIRVTDEYSLGVAMQAAGQLQLAITARLSMSLNNTPMAGTQLNVMSGNFITAQPLGVDDGTDYCHSGRIRRIDIEGINRTLDQGSIVLLGPIASSVTGESFNLLSEEVATQVAIRLKADKLIGFCSEQGVTDESGNVLAELFPKDAKQILERLTESQNPAEDMSTGTLRFLKGAISACRAGVPRCHLISYKVDGALIQELFSFDGIGTQVVMASAEQVRQAQIDDIGGIFDLIRPLEEQGILVRRSREQLEQEVHRFTIIEKDGLIIGCAALYAYPEDHMAEMACVAIHPDYRDGNRGQILLDYMRHQSKSRDIDQIFVLTTHSLHWFREQGFYEIAVDELPMEKQGLYNYQRNSKILALNV
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_PROM5
Sequence: MSKVWSNRFESSLNPFIEEFNASIGFDKTLIFEDIDCSIAHAKMLGKTKVLSADESQKIIEGLENIKQDFIKGEFSPGAPSEDIHYSIEEKLIDLIGDTGKKLHTGRSRNDQVGTDIRLWLRKKIDTIDNLLAELQNSLFAVAESNIYTLIPGYTHMQRAQPLSLAHHFLAYLEMFQRDRERLREVRARVNISPLGAAALAGTKIKIDRYFTASELGFDNIYKNSIDAVSDRDFCIEFASASALIMSHLSRISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGNLHTLLTLIKGVPLAYNKDFQEDKEPIFDTVDTISSCLKAMRILLDEGIEFNVDKLIDSVNNDFSNATDLADYLVSKQVPFRKAYQIVGDIVKYCLTKNILFKDLNLSEFQTFHDEFKEDIYENLNPMNVVKSRNSVGGTGFEQVEIELNNWKKKLFT
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_ACIBY
Sequence: MPRSLKKGPFVDAHLFAKVEAAVASNSRKPIKTWSRRSMILPDFVGLTISVHNGRNHVPVIVTEHMVGHKLGEFAPTRTYRGHGVDKKSKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MAPP_ENTFT
Sequence: MNLLTINTHSWLEEEPLKKLEEIAKVILSSESEIIALQEVNQKVASKKVPLEQLTTFCPIATQTPIHEDNFAYLIVQYLAEKGQHYYWSWEMSHIGYAIYEEGNALLSKCPLTSEALLISESQEPTNYRTRKILVAETESSKGTLTVVSGHFSWWETPCTGFAYEWLQLEKYLAMGQQPLVILGDLNNPAGTTGYQLVENSYLPIQDAFVVAEETSGEATVEKKIDGWEENEAALRIDYAFVPKQWHVRKYEVIFDGRKTPIVSDHFGLLIQLK
What is the function of this protein?
Catalyzes the dephosphorylation of intracellular maltose 6'-P formed during PTS-catalyzed maltose transport, leading to the formation of maltose.  MapP connects PTS-mediated maltose uptake to maltose phosphorylase-catalyzed metabolism.  Is also able to efficiently dephosphorylate turanose 6'-P, and to a much lesser extent, leucrose 6'-P and maltulose 6'-P.  Cannot use glucose 6-P, fructose 6-P and sucrose 6-P as substrates.
What are the official names of this protein?
Maltose 6'-phosphate phosphatase, Maltose 6'-P phosphatase.
Protein: HYPA_METI4
Sequence: MHELSLCESLVSLLEEEMQKLGCGALKKVVLQVGPLALIEEGAMRFAFEVASKGTVVEGAELFIEWIAVRGYCLDCQKEALVYKIGESCPCCGGVMILSEEGKDLKVASIEVE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: ANFC1_ONCMY
Sequence: MLYPALLCAALLLIAPLGHTEGRTLHPSPDAIQFVEQFLDRYNDLTLDDLENLVSSQPEEPSSAFTSGVKVAEYPKWADIPAQGDSTWLRLLKGTLANQKRAVMDRSRRGWNRGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Exhibits natriuretic and vasodepressant activity.  Has a cGMP-stimulating activity.
What are the official names of this protein?
C-type natriuretic peptide 1, C-type natriuretic peptide I, CNP-22 I.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAND_STRM5
Sequence: MHLSLLKTKIHRATVTHSELNYEGSIAIDDNLLAATGIREFEQVHIWDVTNGARFSTYAIRAEAGSGVVSLNGGAARHVQVGDIIIIAAFASMTEQEADSFKPKLVYVDGNNQISHTNDTIPTQAA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KSG3_ARATH
Sequence: MASVGIEPSAAVRESTGNVTDADRLPEEMKDMKIQDDKEMEATIVNGNVTETGHIIVTTIGGRNGQPKQTISYMAERVVGHGSFGVVFQAKCLETGETVAIKKVLQDRRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYLNLVLEYVPETVHRVIKHYNKLNQRMPLVYVKLYTYQIFRSLSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCAALDSLVHPFFDELRDPNARLPNGRFLPPLFNFKPHELKGVPVEMVAKLVPEHARKQCPWLSL
What is the function of this protein?
May mediate extracellular signals to regulate transcription in differentiating cells.  Probably involved first at the cortical polarity site, to restrict MAPK signaling and promote asymmetric cell division (ACD), and second in the nucleus of stomatal lineage ground cells (SLGCs) or meristemoids, to limit cell division and to promote differentiation into pavement or stomatal guard cells, respectively (PubMed:30429609).  Phosphorylate YDA and SPCH in vitro (PubMed:30429609).
What are the official names of this protein?
Shaggy-related protein kinase gamma, ASK-gamma, Shaggy-related protein kinase 12, AtSK12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Note=Localized throughout the plasma membrane in asymmetric cell division (ACD) precursors (PubMed:30429609). Accumulates transiently in a polarized pattern at the plasma membrane immediately before ACD, relocalizing to well-defined foci, in a POLAR-dependent and in the presence of BASL (PubMed:30429609).
Protein: RL14_HELPJ
Sequence: MIQSFTRLNVADNSGAKEIMCIKVLGGSHKRYASVGSVIVASVKKAIPNGKVKFGLVVKTVVVRTKKEIQRKNGSLVRFDDNAAVILDAKKDPVGTRIFGPVSREVRYANFMKIISLAPEVV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: GPR9_AMPAM
Sequence: MEGPPLSPAPADNVTLNVSCGRPATLFDWADHRLISLLALAFLNLMVVAGNLLVVMAVFVHSKLRTVTNLFIVSLACADLLVGMLVLPFSATLEVLDVWLYGDVWCSVWLAVDVWMCTSSILNLCAISLDRYLAVSQPISYPSLMSTRRAKQLIAAVWVLSFVICFPPLVGWNDRPGTLIGSRGSSACRLTCELTNERGYVIYSALGSFFLPSTVMLFFYGRIYRTAVSTTRAIAQGFRTTKEDEEGRLTLRIHRGRSVTQRAEQAAAGGARAHGQVRLTLSEPGARRQNKPSFVVHCREDSRAKNQYEIYTVVEGDSRPGRRVPQPQRPAKKLSSASQSSEDDSRPPRFISRVSRRNVRHQARRFRMETKAAKTVGIIVGLFILCWLPFFVCYLVRGFCADCVPPLLFSVFFWLGYCNSAVNPCVYALCSRDFRFAFSSILCKCVCRRGAMERRFRRTLLVGNRSQTEEDCEVAD
What is the function of this protein?
Orphan G-protein coupled receptor.
What are the official names of this protein?
Probable G-protein coupled receptor No9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP26B_MOUSE
Sequence: MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLSLKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPGQLSDNNSRQ
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway.  The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.  The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity).  May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701).  Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26B, Vesicle protein sorting 26B.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Late endosome. Note=Endosomal localization is reported controversially. Does not localize to endosomes (PubMed:16190980). Localizes to early and late endosomal structures (PubMed:21920005, PubMed:18088321).
Protein: Y2357_AERHH
Sequence: MKKTPSPTDEETQLFRDAIKGTRKIKQDTIRADLRPVKQKRELRESREKLGVDHYFSDEYQPHLEADGPTRYVREDVSKFELKKLKRGSYPPEIYLDLHGMNQQQAKQELAALLTLCQKENIHVASVMHGIGKHILKQRIPSWLAQHPNVQAFHQAPREWGGDSAILVLLDIEE
What are the official names of this protein?
UPF0115 protein AHA_2357.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: CCA_METMA
Sequence: MDTDTSISEDLKLAVLEKIKPTEAERKELMAVQDELAAEVKAAAEKLCVSDIFVKMVGSAARGTWLSGTHDIDVFISFPEETSRKDLEIRGMGIAREVAKHAEYAEDRHAEHPYLNIVYKGFDVDLVPCFRVCSACQLKSAVDRTPFHNEFIKSRIKGREDDVLLMKQFMRGGRVYGSELKTQGFSGYLTELLIIYYGSFEKTVKAASSWKPGKKIDIMQHSELEHSEPLVMVDPTDPKRNVAAALSLDKFCMFIDHCREFLKSPEIKFFFPESPLPIEDKEFLEKLESRKTSQLAIVFETPDVVDDVLYPQLYKMEQAASSLLSEYDFSVIKTGVWSGKPQTVVMLELISGTLPNVKKRTGPPVWVREHAEKFKDKYEGAENVFGGYIENGKYVYEVHRKYTTAKGLLEEQLLNCSLGKQVYQSVNKGFEVIENAEICRLKDQDFRVFLRKWV
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: TOP3_STAEQ
Sequence: MKSLILAEKPSVGRDIANALNLQQKSNGYIEGKQYIVTWALGHLVTNATPEQYNPSYKEWNLEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILDKVGNKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINVDGYDLNLKQQKRYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLTDLQQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATDYKSHVRDLISESFSSKMHIFNNQKVSDHHAIIPTEVRPSIEQLSQREFKIYMLIAERFLENLMNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKALKDQTSSHTLTHSFKEGQLFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRADIIEKLFNMNALESRDGKIKVTSKGKQILELSPSELTSPILTAQWEEKLMLIEKGKYNSQKFIQEMKNFTFKVVNKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCKTKKNIQRKTNARCPYCKKKMTLFGKGKEAVYRCVCGHTETQSQMDKRMRDKTNGKVSRKEMKKYINKKEEIDNNPFKDALKNLKL
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.