PharMolix/UniProtQA huggingface dataset:
Protein: CCKN_RAT
Sequence: MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS
What is the function of this protein?
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.  Its function in the brain is not clear.  Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
What are the official names of this protein?
Cholecystokinin, CCK.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAA_COXBN
Sequence: MNKNPFIVCLMGPTASGKTDLAIALARKLPFEIISVDSAMVYRGLDIGTAKPNEEELQLTSHRLINICDPSFPYSAGQFYKDALSEIKTIEIRNRTPLLVGGTMLYFHILEQGFSDLPTADETVRKKIQEEAAQHGWAKIHERLNAIDPKSAARINPNDAQRIQRAFEVYETTGQPLSSYQSLKRFKALPYQFINLILAPENRSWLHQRIEKRFDQMLKNNFLEEVRQLYNRGDLNSDLPAIRTVGYRQVWKYLSGEYDYETMRHKAIAATRQLAKRQLTWLRRWPDAKWFNSEDKDLISQVVDYLKGIGM
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RL21_CHLCH
Sequence: MQALITISDKQYLVKQGDKLFVPRQQAAIGDKLTIASLAQIDGANTTLQNSNSVQAVVLEHVKDEKVIVFKKKRRKRYQSRNGHRQQMTHIEVLSL
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: MCA2_ARATH
Sequence: MLLLVDCSSCRTPLHLPPGATRIRCAICHAFTLIAPEPRLQSHASASPFPFPNSSPAPSTFIYPPPTPSPYTHAPHAPSPFNHAPPDSYPFTHAPPASSPFNHAPPGPPPPVHGQKRAVIVGVSYKNTKDELKGCINDANCMKFMLMKRFQFPESCILMLTEEEADPMRWPTKNNITMAMHWLVLSCKPGDSLVFHFSGHGNNQMDDNGDEVDGFDETLLPVDHRTSGVIVDDEINATIVRPLPYGVKLHAIVDACHSGTVMDLPYLCRMDRLGNYEWEDHRPKTGMWKGTSGGEVFSFTGCDDDQTSADTPQLSGSAWTGAMTYAFIQAIERGHGMTYGSLLNAMRSTVHEIFDKNKGRELVEVGGADFLSTLLGLLILGASPPDEEEEVNQAPQKTQEPQLSANEAFAVYEKPFSL
What is the function of this protein?
Acts as a negative regulator of oxidative stress cell death and hypersensitive cell death response mediated by immune response.  Acts via indirect or direct regulation of AMC1 at postranscriptional level.
What are the official names of this protein?
Metacaspase-2, AtMC2, Metacaspase 1c, AtMCP1c.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: CAMT_PINPS
Sequence: VGGLIAYDNIEISQIPVGDGVTLC
What is the function of this protein?
Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA.  Plays a role in the synthesis of feruloylated polysaccharides.  Involved in the reinforcement of the plant cell wall.  Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
What are the official names of this protein?
Probable caffeoyl-CoA O-methyltransferase, Trans-caffeoyl-CoA 3-O-methyltransferase, CCoAMT, CCoAOMT, Water stress-responsive protein 13.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.
Protein: RS17_STAAE
Sequence: MSERNDRKVYVGKVVSDKMDKTITVLVETYKTHKLYGKRVKYSKKYKTHDENNSAKLGDIVKIQETRPLSATKRFRLVEIVEESVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PRTIB_ONCMY
Sequence: PRRRRRRSSSRPIRRRRPRRVSRRRRRGGRRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-1B, Iridine IB.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: APOA2_BOVIN
Sequence: MKLLALTVLLLTICGLEGALVRRQAEESNLQSLVSQYFQTVADYGKDLVEKAKGSELQTQAKAYFEKTQEELTPFFKKAGTDLLNFLSSFIDPKKQPATR
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.  Has antimicrobial activity.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Antimicrobial peptide BAMP-1, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRG_PICTO
Sequence: MHYIVITGGVISGLGKGTITSSLSYLLKNSGFKVTNIKIDPYINYDAGTMNPYQHGEVFVLDDGSEVDLDLGNYERFLDTDLTGNNNITTGKIYKSVIERERHGDYLGKTVQIIPHITNEIKERIKRASSGYDIALIEVGGTVGDIESMPFIEAVRQLRSTDDVIYSHVTLVPEINGEQKTKPTQHSVKELRSLGISPDILFCRSEKPLGKDVIEKISLFTDVPASGIISMYNVKNVYMIPEIMMRQGILEYIKKRTGTSNHNLDYTWSNFVENIKNPAESVDIAIVGKYIELQDAYISHKEAFSHVTGNTGISVNIHWVDADKLLNSTHDLKNVDGILVPGGFGYRGVEGKIIAARYARENRIPYLGICLGFQVSVIEISRSLLGLKGANSTEFDNNTDYPVIDILPEQSNVSDLGGTMRLGSKKVLIKDGTIAKNIYKSDIIYERHRHRYEVNPDYIERLEDSGVIFSGTDDEKIRMEILELSDRDNYIATQYHAEFKSRPLNPSKVHMHLVLKALEYRRNIYERNTSGISR
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TAFA5_MOUSE
Sequence: MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
What is the function of this protein?
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251, PubMed:29138422).  Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (PubMed:29138422).  Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (PubMed:29138422).  Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (PubMed:29138422).  Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity).  Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251).
What are the official names of this protein?
Chemokine-like protein TAFA-5.
What is the protein family that this protein belongs to?
Belongs to the TAFA family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_YERPG
Sequence: MKAQELREKSVEELNTELLNLLREQFNLRMQAASGQLQQTHLLKQVRRNVARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: M2_I57A3
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCNYRFFKHGLKRGASTEGVPESMREEYRKEQQSAVDTDDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: PFL_CLOPA
Sequence: MFKQWEGFQDGEWTNDVNVRDFIQKNYKEYTGDKSFLKGPTEKTKKVWDKAVSLILEELKKGILDVDTETISGINSFKPGYLDKDNEVIVGFQTDAPLKRITNPFGGIRMAEQSLKEYGFKISDEMHNIFTNYRKTHNQGVFDAYSEETRIARSAGVLTGLPDAYGRGRIIGDYRRVALYGIDFLIQEKKKDLSNLKGDMLDELIRLREEVSEQIRALDEIKKMALSYGVDISRPAVNAKEAAQFLYFGYLAGVKENNGAAMSLGRTSTFLDIYIERDLEQGLITEDEAQEVIDQFIIKLRLVRHLRTPEYNELFAGDPTWVTESIAGVGIDGRSLVTKNSFRYLHTLINLGSAPEPNMTVLWSENLPESFKKFCAEMSILTDSIQYENDDIMRPIYGDDYAIACCVSAMRVGKDMQFFGARCNLAKCLLLAINGGVDEKKGIKVVPDIEPITDEVLDYEKVKENYFKVLEYMAGLYVNTMNIIHFMHDKYAYEASQMALHDTKVGRLMAFGIAGFSVAADSLSAIRYAKVKPIRENGITVDFVKEGDFPKYGNDDDRVDSIAVEIVEKFSDELKKHPTYRNAKHTLSVLTITSNVMYGKKTGTTPDGRKVGEPLAPGANPMHGRDMEGALASLNSVAKVPYVCCEDGVSNTFSIVPDALGNDHDVRINNLVSIMGGYFGQGAHHLNVNVLNRETLIDAMNNPDKYPTLTIRVSGYAVNFNRLSKDHQKEVISRTFHEKL
What are the official names of this protein?
Formate acetyltransferase, Pyruvate formate-lyase.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STEA3_MOUSE
Sequence: MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLATRLVGSGFSVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLADQLAGKILVDVSNPTEKEHLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPRDGNRQVLICSDQPEAKRTISEMARAMGFTPLDMGSLASAREVEAIPLRLLPSWKVPTLLALGLFVCFYTYNFIRDVLQPYIRKDENKFYKMPLSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLPLRRSHRYDLVNLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANSLNWKEFSFVQSTLGFVALILSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGLFLLPCLSRRLTKIRRGWEKDGAVKFMLPGDHTQGEKTSHV
What is the function of this protein?
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.  Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+).  Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis.  Uses NADP(+) as acceptor.  May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression.  Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
What are the official names of this protein?
Metalloreductase STEAP3, Dudulin-2, Protein nm1054, Six-transmembrane epithelial antigen of prostate 3, Tumor suppressor-activated pathway protein 6.
What is the protein family that this protein belongs to?
Belongs to the STEAP family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein.
Protein: SSRP_CUPTR
Sequence: MTIADNKKAFFDYFIEERYEAGIVLEGWEVKAIRAGRVQIKEGYVVVRDAEMFLIGAHISPLQSASTHVKPDPVRTRKLLLKADEIKKLIGKVEQRGYTLVPLNLHYTRGRVKCEIGLAKGKKQFDKRETEKQRDWQREKARIMKGGKE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: QWRF4_ARATH
Sequence: MQVGSKKASMGKQQQSVSDATSPRPPLAPSEKNNVGSVTRRARTMEVSSRYRSPTPTKTRRCPSPIVTRTAPSSSPESFLKRAVSAERNRGPSTPTTPVSDVLVDLPVSSRRLSTGRLPESLWPSTMRSLSVSFQSDSVSVPVSKKEKPLVTSSTDRTLRPSSSNIAHKQQSETTSVTRKQTPERKRSPLKGKNVSPGQSENSKPMDGSHSMLIPPQHRWSGRIRGNRSFDLGDKAVRRVSLPLSNKSSRHKKSSSDITRLFSCYDNGRLEVSSSTTSEDSSSTESLKHFSTSSLPRLHPMSAPGSRTASPSRSSFSSSSSSNSRGMSPSRGVSPMRGLSPVGNRSLVRSSTPPSRGVSPSRIRQTAQSSSTNTSVLSFIADVKKGKKATYIEDVHQLRLLYNRYSQWRFANARAEGVSYVQSLIAKETLYNVWHAISDLRDLVTTQRICLQQLKLEIKLRSILNDQMVCLEDWAMVEREHISSLAGAIGDLEANTLRLPLAGGTKADLGSLKLAMSSALDVMQSMGSSIWSLHSQMEEMNKLVSDLAVIAKTENFLLDKCENLLASTAVMEIEERSLKTHLIQKKQEEEVRDDAESSPLLPLSKFQWP
What are the official names of this protein?
QWRF motif-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the QWRF family.
Protein: RPOB_CAMFF
Sequence: MLNSLYSGNRLRVDFSNVAKEIDVPNLLQLQKKSFDHFLNLDNSQTESGIEKVFKSIFPIHDPQNRLTLEYVSSEISKPRYTVRECMERGLTYCVNLKIKIRLIVHDRDEKTSEKVGVKDIKEQEIFVREIPLMTDRISFIINGVERVVVNQLHRSPGVIFKEEESPTVVNKLIYTAQIIPDRGSWLYFEYDTKDVLYVRINKRRKVPITILFRALGYKKQDIVKLFYPIQTLNIKNNKFLTMFNPDDFSGRVDYDIKDEDGNILHQAGKRLTKKKADKLIEDGLKFVEYPIEVLVNRYLASPVIDKESGEVIYDTLTQLDENKLAKIVAEQNSIEIANDLASGVDDAIINSFLQDYETLKLLKQTEGLEDENDLAAIRIYKVMRPGEPVVKEAARTFVNDLFFNPERYDLTKVGRMKMNHKLGLSVPEYVTVLTNEDIIKTAKYLIKVKNGQGYIDDRDHLGNRRIRSIGELLANELHLGFVKMQKAIRDKFTSLSNNVDELMPYDLVNPKMITTTIMEFFTGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKERAGFEVRDVHPTHYGRICPVETPEGQNIGLINTLSTYAKVNDLGFVESPYRRVIDGKVTNEIVYLTATQEEGHIIAPASTVLDANDIIKEDLIEVRRDGEMLLAKREDVTLIDLCSGMVMGVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSTAPIVGTGMEAIVARDAWEAIKAKRGGVIEKVDNRNIFILGEDENGPYIDQYTMEKNLRTNQNTTFSQHPIVKKGDMVKSGQIIADGSSMEKGELAIGKNALIAFMPWNGYNYEDAIVMSERMIRADAFTSVHIYEKEIEARELKDGVEEITRDIPNMKEEDLMHLDESGIVKIGTHIKPGMILVGKVSPKGEVKPTPEERLLRAIFGEKAGHVVNKSLYAGASLEGVVIDVKIFTKKGYEKDARSFKAYEDEKNILEKEHHDRLLMLDREEMLRVTALLSKNPLESELEIGKNSYKKGDKIKRSDLDNVNRFTLNTYVKCFSKEIQKTYEDMKAYFQNEKKKLKDEHDAKLEILEKDDILPSGVVKLVKVYLATKRKLKVGDKMAGRHGNKGIVSNIVPDVDMPYLPNGRTVDIVLNPLGVPSRMNIGQILESHLGLVGMKLGEQIEEIFENKKAEWIKELRAKMTEIADVSRLMDAKAILSKIDDDKLIDYARDWASGVRFATPIFEGVKADEFKKLFEMAKIDMDGKTELYDGRTGSKMAERVNVGCMYMLKLHHLVDEKVHARSTGPYSLVTQQPVGGKALSGGQRFGEMEVWALEAYGAAHTLREMLTVKSDDVEGRLAAYKALTRGENVPSTGIPETFFVLTNELKSLALDVEIYDEEENNE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RIMKB_MOUSE
Sequence: MCSSVTGKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEMVLTVEQGNLGLRISGELISAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYIKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGTDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIADYAASLLPAGRLTRRMSLLSVVSTASETSEPELGPPASAAVDNMSASSSSVDSDPESTTEREMLTKLPGGLFNMNQLLANEIKLLVE
What is the function of this protein?
Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate.  Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.
What are the official names of this protein?
Beta-citrylglutamate synthase B, N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_THEAB
Sequence: MPNIKSAKKRVKVSERNRLINKAYKTRMKNSIKKVLLALQEGKSREEVEQLYKVAQSAIDKAAKIGAIHKNQASRRKSRLIAKINKHFASKE
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: IF2A_PIG
Sequence: MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRXXC
What is the function of this protein?
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.  EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Note=Colocalizes with NANOS3 in the stress granules.
Protein: TMM65_MOUSE
Sequence: MSRLLPLLGSRTARSLRPGPAAAPRLPSWCCCGRGLLALGVPGGPRLLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEALPPTPGQLRYVFFHNAIPFVGFGFLDNAIMIVAGTQIELSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRVSTHLGKAVGVTIGCILGMFPLIFFGGSEEDEKLETTN
What is the function of this protein?
May play an important role in cardiac development and function.  May regulate cardiac conduction and the function of the gap junction protein GJA1.  May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541).  Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).
What are the official names of this protein?
Transmembrane protein 65.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Localizes at the intercalated disk in ventricular tissue and cardiomyocytes.
Protein: PURA_PHYIT
Sequence: MRLDVVSKAARAAQRFSAQCHGQKFRTAHASATLRAALAVEASEANQKGRSAGLLAAMALMGVAGVASMDDNAAAKCEGAAKPVSREAVTQAMLKEVVTKLNRIESAVANPHRHTDGLNVGVDVVLGAQWGDEGKGKLVDSLSQSYDVIVRVAGGSNAGHTIVHEGKKYKFHLVPSGILNPNAICIIGNGVVVHLPSFLEELEELKRMGVDYEGRILISDRAHMVLDLHQEVDGINELRRGRNKIGTTKKGIGPAYSSKMLRNGVRVGDLRYFDDFTEKMVDLVKFYKDNYPELEADAEAEIKVYSDMKDKILDMTVDTVSYLNNAYVAGKKILVEGANATMLDIDFGTYPYVTSSNPSIGSVCTGGGISPNRLNGIIGIVKAYCTRVGEGPFPTELHDDVGEHLGTVGAEFGTTTGRARRCGWLDIPQMRYSNMVNGFTELNLTKLDVLTGLKKVKIGVAYWHEGKKLDGMPSNLQLLQDSVVEYEEMEGWSEDISKCKTFEELPVAAQKYVLRVEELLGTHIKWIGVGPDRFDVITRTHPLEKAYISGN
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULP2A_ARATH
Sequence: MTLRSVQSRSKRKPIDVFDYSDEDDRVEEESKKLLRKFDSPVTKKHHCAIDKYEFLRCFAKDTQSESKVLQHIVIDVEVPVKEEPSRCELSGDGNSDLIDVISNGSHRRIGIDSLTSSSLSENDEVSTGEATNPASDPHEVDPENAQVLIIPDVIIYGDIYCTNSKLTFSRNCMNVESSSVNATKGTFSCQWTIEDIIKIESQWCLEVETAFVNVLLKSRKPEGVDIAKDISGIDLLKFSVYDPKWSKEVETIRSLDSRYKNIWFDTITESEEIAFSGHDLGTSLTNLADSFEDLVYPQGEPDAVVVRKQDIELLKPRRFINDTIIDFYIKYLKNRISPKERGRFHFFNCFFFRKLANLDKGTPSTCGGREAYQRVQKWTKNVDLFEKDYIFIPINCSFHWSLVIICHPGELVPSHVENPQRVPCILHLDSIKGSHKGGLINIFPSYLREEWKARHENTTNDSSRAPNMQSISLELPQQENSFDCGLFLLHYLDLFVAQAPAKFNPSLISRSANFLTRNWFPAKEASLKRRNILELLYNLHKGHDPSILPANSKSEPPHCGVSNRNDQETESENVIECCNWIKPFDGSSSTVTDISQTKTCSPDLILSKEVSYSGGYDPPSSKLRKVFMSPIVEEVQESCEKKDHLEMDIQKSTGHEIETLRKEGCMLYIEDSDDEEAVSVEYVSDSQDSYEVEMKVEDDDDDELIVTGESSGIHGSREIKSDSASIERVNKSRDSTAASCYNDFLLVLSDDERSSDDKENILISSNVMAKPKT
What is the function of this protein?
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
What are the official names of this protein?
Probable ubiquitin-like-specific protease 2A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
Protein: PTH_DELAS
Sequence: MIKLFVGLGNPGPEYEDTRHNAGFWWIDALARELKVQLVPERSYFGLMARASVRGENVWLLQPQTFMNLSGKSVGALARFFKIQPEEVLVVHDELDFEPGQVKLKRGGSHGGHNGLRDIHAQLGSADYWRLRIGIGHPGHKAEVANWVLKKPAPDQRQLIEDSIAHSLKAWPELQAGNMDKATLLIHTTKPPRPKPARPATAESDKG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTB2_BACIU
Sequence: MSEDQYKQIKLHLGMEDDNEDLPNHIPSSFPKQHLNKIYNGDTMNMLLDIPDNSVDLVVTSPPYNINKFKNDRRPLEEYLKWQTEIIEQCHRVLKPSGSIFWQVGTYVNDSGAHIPLDIRFFPIFESLGMFPRNRIVWVRPHGLHANKKFAGRHETILWFTKTPEYKFFLDPIRVPQKYANKKHYKGDKKGELSGDPLGKNPGDVWAFRNVRHNHEEDTIHPTQYPEDMIERIVLSTTEPNDIVLDPFIGMGTTASVAKNLNRYFYGAEIEKEYVDIAYQILSGEPDENNNFPNLKTLRQYCEKNGIIDPSQYTFTRQRKGSKPSLDSKAHPEEHHKKEIVERIEFEAENSVYKKVQNEQ
What is the function of this protein?
A beta subtype methylase, recognizes the double-stranded sequence 5'-AGATCT-3', methylates C-5 on both strands, and protects the DNA from cleavage by the BglII endonuclease.
What are the official names of this protein?
Type II methyltransferase M.BglII, M.BglII, Modification methylase BglII, N(4)- cytosine-specific methyltransferase BglII.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Protein: KTHY_RICRO
Sequence: MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELFQAMAARYDHMARKIIPALQEGHIVICDRFIDSTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.