Protein: MDC1_MACMU
Sequence: MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGGTQPQRLLLAEDSEEEVDFLSERHVVKKSRTTSSPVAMIVPESDEEGHSPVLGGPGPPFAFNLNSDTDAEEGQQSATEEASSAARRGATIEAEQSEAEVVTEIQLEKDQPSVKERDNDTKVKRGAGNGVVPAGMILERSQPPGEDSDTDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEEGIPATPVVVPMKKRKIFHGVGTRGPGAPGLSHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLARLKESQPAVWNRDAEEDMAHHAVLLQRSQTTTGRDSDTDVEEEELPVENKQTVPKAHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASITVDINTQVEEEVPPGSAIVHMKKHQVSMEGTNQTDVKADGGPAKLLVVSLEEASPPHGDCEIDAEEGTSLAASAVADVRKSQLPAEGDAGAEWTAACLKQERAYEVGAQGGSPVAQVEQDLPTSRENLTDLVVDTDTPGESTQPQREGAQVPTGREREQHVGRTKDSEDNCDDSEDPDLQATQCFLENQGLEAVQSMEDEPTQAFMLTPPQELGSSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKGMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTRGIQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSKEIQGKQVQKQTLPSKAFEREVERPVADRECEPAELEEKVPKVILERDAQRGEPKGGSQDQKGQASSPTSEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPTEKASRIGAAEKASRGDQESPDACLPPTVPEASAPPQKPLNSQSQKHLAPQPLLSPLSPSIEPTIRKTGQDRSQEAPETPLSSELEPFHPKPKIITRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTVPELQPSTSTDQPVASEPTSQATRGRKNRSSVKTPEAVVPTALELHPSNSTDQPVTPKPTSEAIRSRTNRSSVKTPEAVVPTALELHPSNSTDQPVTPKPTSEAIRSRTNRSSVKTPEPVVPTVPELQPSTSTDQPVTSEPTSQATRGRTNRSSVKTPEPVVPTVPELQPSTSTDQPVASEPTSQATRGRKNRSSVKTPEAVVPTALELHPSNSTDQPVTPKPTSRTTRSRTNMSSVKTPESTVPIAPELPPSTSTEQPVITEPTYQPTRGRKNRSSVKTPETVVATAPKLQSSTSTDQPITPEPTSQATRGRTNRSSVKSPETVLRTAPELQPSTSTHQPVTAKHTSQATRGRTNRSSVKTPEPVVSTAPELQPSTSTHQPITPEPTSQATRGRTDRTSVKTPKIVVPTVPELQASTSTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPTAPEPHPTTSTDQPITPKPTSRATRGRTNRSSVKTPELIVPIAPEFHPSTSRSQLVTPEPTSRATRGRKNRSSVKTPEPAVPTAPELHPTTSTDQPVTPKPTSRATRGRTNRSSVKTPEPVEPAASDLEPFTPTDQPVTPEAIPQGSQSKTLRSSTVSAMLIPTTPEFQSPVTTDQPISPEPIPQASCIKRQRATGNPGSLTAPIDHKPCSAPLEPKSRPSRNQRWGAVRADESLTAIPEPASPQLLDIPTHASQIQKVEPAGRSRFTPELQPKASQSRKRSLAIMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVMTPKPGKRKRDQAEEEPNRIPNRSLRRTKLNQESTAPKVLFTGVVDAQGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGCFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPRCSVPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST
What is the function of this protein?
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle.  May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX.  Also required for downstream events subsequent to the recruitment of these proteins.  These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis.  ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
What are the official names of this protein?
Mediator of DNA damage checkpoint protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks (By similarity).