PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_PROMT
Sequence: MTNVPISRLRNFCIIAHIDHGKSTLADRLLQDTGTVSSRDMQEQFLDNMDLERERGITIKLQAARMNYKADDGEEYVLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANVYLALENDLEIIPVLNKVDLPGADPEKIKNEIESIIGLDTSKAISCSAKTGVGIPEILQAVVDRIPSPKDNTDQATKALIFDSYYDPYRGVIVYFRIMSGGISKKDKVLLMSSKKSYELDEIGVMAPDQVKVNSLHAGEVGYLAASIKAVADARVGDTITLVDRPAQDALPGYAEAKPMVFCGLFPTDADQYPDLRDALDKLQLSDAALKYEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYDLDLIVTAPSVIYKVKMIDGEIRMIDNPATLPDPQKRETIEEPYVRMEIYAPNDYNGTLMGLCQDRRGDFIDMKYITTDRVTLIYEIPLAEVVTDFFDQMKSRTKGYASMEYHLIGYRENDLVRLDVLINSERADPLTTIVHKDNAYGVGKGLVEKLKELIPKQQFKIPLQASIGSRIIASEGISALRKDVLSKCYGGDISRKKKLLKKQAKGKKRMKSMGKVDVPQEAFMAVLKLNKD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDNF_DANRE
Sequence: MTWRCGCYGLVLLVLGVMGQKLPTRDEGLFQMQIRDKAQFHDSSVMPDGAEISGYLFRDTPKRYYFVVEEDNTPLLVTVTPCDAPLEWRLTLQELPEDRSGEGSGEPEPLEQQKQQVTANEGTELFTYKGNDVESFISSSSPSGLYQLEIISTEKDSNFKIYSTTTPESDQPYPELPYDPRVDVTALGRTTVTLAWKPTPTGSVMGQPIQYCVVINKEHNFKSLCAAEAKMSLDDAFMIAPKPGRDFSPFDFAYFGFVPSENDFHKDRFLTTNRALSNKMSRAYIPKPKVADIQKICIGNKNIFTITDLKPDTQYYFDVFAVNTGTNMSTAYVGTFARTKEEAKQKTVELKDGKVTDVFVKRKGSKFLRFAPVSSHQRVTLFVHACLDAVQVQVRRDGKLVLSQNVEGVRQFQLRGKPKAKYLIRLRGSRKGASTLKVLASTRAGGKQPFPALPEDTRIKAFDKLRTCSSVTVAWLGTQERNKYCVYRREVSESYGEEHRRREQNQCSGPESRRKSEKVLCKYFYSANLQKAVTTETITGLEAGKSYLLDVYVVGHSGHSVKYQSKLVKTRKYC
What is the function of this protein?
Secretory protein that plays a role in various cellular processes.  Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645).  Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system.  May also act through the regulation of growth factors activity and downstream signaling (By similarity).  Also regulates extracellular matrix assembly and cell adhesiveness (By similarity).  Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (By similarity).
What are the official names of this protein?
Protein NDNF.
What are the subcellular locations of this protein?
Secreted.
Protein: MAUN_METFK
Sequence: MTNMGAIRAALYRRRWLLSRRVVQMFIVLAFLVDWPEVGRIAHGNLSSSLWLGVLPLTDPFIALQSLFSGTMLAKTALVGTVIVAGFYFLFGGRIYCSWVCPINMVTDLAYWLRQKLNLKGNMTMSRELRMAVLGMSLILTVLSGTLAWENFNPITLFQRELMWTSVAGSMVLLSLFLFDLLITRRGWCGHLCPVGAFYAVLGRYGRLRVTAEQSGSCAGCGSCIRVCPEPHVLAPVVSLKANTVTHGDCTRCGACLDQCATGALAMKLDLGKSFRGIPIVRK
What is the function of this protein?
Involved in electron transfer.
What are the official names of this protein?
Methylamine utilization ferredoxin-type protein MauN.
Protein: SPEH_THEMA
Sequence: MKSLGRHLVAEFYECDREVLDNVQLIEQEMKQAAYESGATIVTSTFHRFLPYGVSGVVVISESHLTIHTWPEYGYAAIDLFTCGEDVDPWKAFEHLKKALKAKRVHVVEHERGRYDEIGIPEDSPHKAAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: SSPH1_GEOKA
Sequence: MDVRRAQEIASSPVMANVTYNGQRIYIEHVDQQKGVATIHPLDNPNQKQSVPVASLEEHS
What are the official names of this protein?
Small, acid-soluble spore protein H 1, SASP H 1.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.
Protein: SYC_CUPNH
Sequence: MQLLNIYNTLAREKQPFVPIEPGKVRMYVCGMTVYDYCHVGHARVMVVFDMVHRWLRAAGYEVTYVQNITDIDDKIIRRAAENGETIGELTTRFIQYMHEDAAALGVIRPDHEPRATDYVPQMLDMIGKLEAKGLAYQASDGDVNYSVRKFAGYGKLSGKSLEDLRAGERVSANDAKQDPLDFVLWKSAKASEPPESKWDSKWGAGRPGWHIECSAMSCTLLGEHFDIHGGGADLQFPHHENEIAQSEGASGKPFVNMWMHNGFVRINDEKMSKSLGNFFTIREVLKSYDAEVVRFFILRAHYRSPLNYSDAHLDDARHALTRLYTALKDSQPGGCAVDWDEPHARRFAEAMGDDFNTPIAMSVLFDLASEINRTGSTAAARQLKGLAGTLGLLERDPHTFLQGGRSDDGISPEQIETLIAARKTAKVERNFAEADRIRAQLLEAGIVLEDKPGGATEWRRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN_COECR
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQKLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ADA22_MOUSE
Sequence: MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLERQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFYDGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI
What is the function of this protein?
Probable ligand for integrin in the brain.  This is a non catalytic metalloprotease-like protein.  Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity).  Neuronal receptor for LGI1.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 22, ADAM 22.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon.
Protein: MURD_MYCPA
Sequence: MSAAEPALAPLSPGAPVLVAGGGITGRAVLAALRRFGAAPTLCDDDPATLRGYVDSGVDTVSTSAAAERISRYALVVTSPGFAPTAPLPLAAAAAGVPVWGDVELAWRLDVAGHYGPPRRWLVVTGTNGKTTTTSMLHAMLTAAGRRSLLCGNIGSPVLDVLDQPAELLAVELSSFQLHWAPSLRPEGGAVLNIAEDHLDWHGTLADYAAAKARVLDGRVAVVGLDDSRAAALLSTARAPVRVGFRLGEPAAGELGVRGGQLVDRAFADDLTLLPVDSIPVPGPVGVLDALAAAALARCVDVPASPIAEAIVSFRVGRHRAEVVAVADGITYVDDSKATNPHAAEASVLAYPRVVWIAGGLLKGASVDAEVARMASWLVGAVLIGRDRREVAEALSRHAPDVPVVHVVTGEDAGMDATPVVFGANVTKVKHLGGDLGAAVMSAAVAAARDLAKPGDTVLLAPAGASFDQFAGYADRGEAFAAAVRAAIR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDC80_XENLA
Sequence: MRRSSVTNRQSLLPLRVQDANRMGLTTPQNKDRQGFGKLSMSKPHSGTSEKKTSFFGKRASNGTARTSQYGAFGGTEKIKDPRPLHDKAFIQQCIRQLCEFLNENGYSQALTVKSLQGPSTKDFLKIFAFIYTFICPNYENPESKFEEEIPRIFKELGYPFALSKSSMYTVGAPHTWPQIVAALVWLIDCVKLCCVLRSENPVFEDPPMGEQSENGIDFNQLFLDYTVRCYDQFMEGRDTFEEYDTDVCIRLKEAYHVDESNLEALQQESRRLMEEIERLEKEKENEPDRLASMRKLKASLQADIQKYQNYLTEIESHSTLLDQRVSSISEELEATELESRAIQQENLRLKNILDNQKYSVADIERIKYEETELQQTIAKLTKDLDEDKQQLWHEELKYAKMKESVETQLSEFHKIGRKVRLIPPTAEFANGYDFQIQCNLDSEQSSLMHYRNKINVPLVEILSQSEGHIASSTNKKMGVEDMVEQLNTLIGEKKNEVKVQKDEAQKLEEIYQQKVEESEEHEKRWISEIESLEKHRQLLESGVNKSLDEAMKDLQKEQQELQLVEHRTEEEMRQVENKLVRVVHAVANHVAVIEKHLEEKRLKVEREYEEFMKEDLLLDLRELLEKYKEKARVLDSL
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12514103, PubMed:14738735).  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.  May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity).
What are the official names of this protein?
Kinetochore protein NDC80 homolog, Kinetochore protein Hec1, Kinetochore-associated protein 2, xNdc80.
What is the protein family that this protein belongs to?
Belongs to the NDC80/HEC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: TSAC_MYCTU
Sequence: MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADAFDSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVVVQAPSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARSQLGDHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRPGPVSTERIAEVLGVDAASLFG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Putative threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, tRNA threonylcarbamoyladenosine biosynthesis protein Rv1301.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G1PDH_METS5
Sequence: MEIHEHIIELPKKVYVGNGILSKLRDYLFQLNVLEPVLVVTGPNVRKIVIDEVAKGLNEIGKIEFIEVLDSSIDEVNRVEEKAKQLNPKFVLGIGGGKTIDVAKYVAYKLNVNFISIPTAPSHDGITSPFASIKGLGKPVSVKAKMPYAIIADINVLSSAPRRLINSGIGDTIGKLVAVRDWKLASKLTGEYYGDYTASLALLSAKHALSCTRIIHRDLKYSVSLLTEALISSGVAMGMAGSTRPASGSEHLFAHAVDLLQPNAALHGELVGMGSIIMAYIHGINWREIRNALDRIGAPTTAKQLGIPNDVIIKALTIAHTIRPERYTILGDRGLTWASAEKVARDTGVIE
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_NEOYE
Sequence: MVQRISLKNKLLPDLVEIQRASFKWFLLEGLTEVLEIFPKISDPTSRLELQLFGNEYKIKFPRYSVRQAKNRDKTYSAQIYVPAKLTRKDIDLPSKNQEKNIKSLDLSSTHLQLSAEKQIKNKKYKKRLVFIGDLPIMTNRGTFIVSGTERVIINQIIRSPGIYYKQEIDKNGKQIYSASLISNRGSWLKFEIDPKGEIWIRIDKTHKVNAYIFLRAIGLNKDEIEKGLSKYAFLISASQIYSVKELAKEIGKNNIEEVTDEEALLIVYSKLRPNEPATVAVAKQMLYSRFFDPKRYDLGEVGRYKINKKLGLNIPKTFRVLSPQDILSSIDYLINIKDKNSGNLDDIDHLGNRRVRSVGELLQNQFRVGLNRLERIIRERMMICDIDSLSLSNLINPKPLIASVREFFGSSQLSQFMDQTNPVAELTHKRRISALGPGGFNKDRAGFAVRDLHPSHYGRICPIETPEGPNAGLIGSLATCARVNVFGFIETPFYPVNQGQVIYHNSPVYLTADEEDDFRVAPGDVKVSKQHYIEGDIIPVRYRQEFITTTPTQVDYIAISPIQVISAATSLIPFLEHDDANRALMGSNMQRQAVPLLYPEKPIIGTGLETKIARDSGMVVISRTSGHVNYVSANKIGIQDNSGRTVHYRLKKYYRSNQDTCINQRPIVWVGEKIVVGQTLADGASTDGGEIALGRNILVAYMPWEGYNYEDAFLISERLVYDDLYTSIHIEKYEVECRQTKLGPEEITREIPNVSDNSLKDLDRNGIVVGGSWVEAGDILVGKITPKGEADQLPEGKLLRAIFGEKARDVRDTSLRLPNAAKGRVVKVRVFTRQKGDELPPGTNAMIRVYVAQKRKIQVGDKMAGRHGNKGIISRILPKQDMPYLSDGTPVDIVLNPLGVPSRMNVGQVFECLLGLAGGYLGKRFKIIPFDEMYGAEASRALVNRKLKEASLITSNKWLFNDQHPGKMQVFDGRTGEPFDNPVTVGRAYMLKLVHLVDDKIHARSTGPYSLVTQQPLGGRAQHGGQRLGEMEVWALEAFGAAYTLQELLTVKSDDMQARNEALNAIVKGKPIPKPGTPESFKVLMRELQSLGLDIAVHKLKLFEDGQRRTVEVDLMSDSKDNRVDRSNYDTPPVDDFEQFLY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MIAB_HAEIG
Sequence: MTQKLHIKTWGCQMNEYDSSKMADLLLSTHGLELTEAPEEADVLLLNTCSIREKAQEKVFHQLGRWKELKKNNPNLVIGVGGCVASQEGEHIRHRAPYVDIIFGPQTLHRLPEMINQIRGGKSSVVDVSFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTFCVVPYTRGEEVSRPVDDVLFEIAQLAEQGVREVNLLGQNVNAYRGPTHDGQICSFAELLRLVASIDGIDRLRFTTSHPIEFTDDIIDVYRDTPELVSFLHLPVQAGSDRVLTMMKRAHTALEYKSIIRKLRAVRPDIQISSDFIVGFPGETAEDFEQTMNLIAQVNFDMSFSFVYSARPGTPAADMPDDVTEDEKKQRLYVLQERINQQAAQFSRRMLGTEQRVLVEGPSKKDIMELTGRTETNRIVNFQGSPEMIGKFVDVKITDVYTNSLRGEVVRTEDEMGLRIAQSPQEVMNRTRKEDELGVGRYHG
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_STACT
Sequence: MTKFIFVTGGVVSSLGKGITAASLGRLLKDRGLSVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLSRENVMYIHCTLLPFIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDIPEQNVIECRDAESLYEIPLQLSKQHMDDLVIKRLDLNAKYDTQLDEWKHLLDVVNHLDGEITIGLVGKYVSLQDAYLSVVEALKHAGYPLHKDINVKWIDSSEVTDENAAEFLKDVDGILVPGGFGYRASEGKISAIRYARENNVPYFGICLGMQLATVEFARNVLGLEGAHSAELDPETPYPVIDLLPEQKDIEDLGGTLRLGLYPSEVKEGTLAYDIYGKKEIEERHRHRYEFNNDYREQMEDNGLVFSGVSPDGRRIEMVELPKNDFFFACQFHPEFLSRPNRPQPIFKAFIEAANKYKEAKENK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: COMP_HUMAN
Sequence: MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA
What is the function of this protein?
Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin.  Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed:16542502, PubMed:16051604).  Could play a role in the pathogenesis of osteoarthritis (PubMed:16542502).  Potent suppressor of apoptosis in both primary chondrocytes and transformed cells.  Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed:17993464).  Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli.  Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
What are the official names of this protein?
Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RL5_EHRCJ
Sequence: MLKDLYKSHIVPSLKTKLGYSNVMQVPKIVKVCLNIGLGIRGSDSKVMNSCVRDLALIAGQKPVATYAKKSIAGFKIRKGFPIGCKVTLRNNKMYEFLERLIHVVLPREQDFKGLSVNQFDGCGNLSIGIKEHISFLEIDYDKIDKILGLDINIVTNAVNNNDAKLLLMEFGFPFIN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: LDHD_STAAC
Sequence: MTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVINTGTCETRLN
What are the official names of this protein?
D-lactate dehydrogenase, D-LDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: RRF_ALIB4
Sequence: MLQEVYAQTKEHMEKSIEALKKDYKSLRTGKVNTNILDGIKVDYYGTMTDLSQVGSVLATDATTITINPWEKNLLGTIEKAIQNANIGVNPNNDGQIIKLFFPPMTVEQRQETAKHAKTMTDNAKVAIRNIRQNSNNKVKTLLKDKAITEDESKKAQDEIQKITDSYVLKADETLKAKEKEILTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 141R_IIV6
Sequence: MYYRRQGEPQEMYGNGNNSVSSSAVNTYQPYYKEDFNILDPALSDSQRYIIYAIVAAILLLLFWLLYKKYGHKIGRKGSVSMFY
What are the official names of this protein?
Uncharacterized protein 141R.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TILS_TREPA
Sequence: MSESRQKLHPLLVHVARSFGHFLVPRKPSCLLVAVSGGADSLALLYAAHELAPDFGVCACAVTVDHSLRAQEGALDARFVRALCARFSPPLPCFVQQISAGAVHACAKIRGRGVQDAARALRYKVFDHVAARCGAQVVLTAHTRDDQYETLLMRLFQGAAASALQGIRAARGRYVRPLLKVSRTCVEDFLQTRGVRWREDASNTCRKYVRNRIRHELIPALDAVLAGWRSGLDKTFAGISAEHSFCVAALTRWREGCSHAWEPVPRALGTRLRMPRSDFLAAEFILRFFLLQEACVRLGVSHRVPRGALERCARFDGVRRIHVSGLQLERAGAYVLFSCIHASDTARETKKQDAGSPPSSEKQGVSAIYVARPGAYPCACGTLLVEVRPAGVFVCCAQDHVGVGPFSFPFYIRTHRTGDTISIRGGHKGIRKMFSEWHVPLSDRTVLPMIEQDGVLRALYGAALGYQNRYAERTPHE
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_CHRSI
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLMIQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDLLGVLILMLSLMILVLFFPDLLSDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAFLPFLHTSKQRSMIFRPITQMLYWVLVANLLVLTWIGGQPVEHPFIIIGQLASISYFSIILILMPVSGIIEDKLLKWSL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CSP3_STRMT
Sequence: MKNTVKLEQFVALKEKDLQKIQGGEMRKSNNNFFHFLRRI
What is the function of this protein?
Acts as a pheromone, induces cells to develop competence for genetic transformation.
What are the official names of this protein?
Competence-stimulating peptide, CSP.
What is the protein family that this protein belongs to?
Belongs to the ComC family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURA_ALIFM
Sequence: MYKFRIQGSDKPLSGEVTISGAKNAALPILFASLLAEEPVEVANVPKLRDVDTTMELLKRLGAEVSRNGSVHIDASGVNDFCAPYDLVKTMRASIWALGPLVARFGKGQVSLPGGCAIGARPVDLHIHGLEQLGATIKLEEGYVKAEVDGRLKGAHIVMDKVSVGATITVMCAATLAEGTTVLENAAREPEIVDTANFLNAIGAKVSGMGTDTITIEGVERLGGGYHEVVADRIETGTFLVAAAVSGGKIVCKNTKAHLLEAVLAKLEEAGADVQTGDDWISLDMTGRELKAVNIRTAPHPAFPTDMQAQFTLLNMMAKGSGIITETIFENRFMHIPELQRMGAHAEIEGNTAICGDTDGLSGAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGYDKIEDKLTALGANIERVHSDDL
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.