PharMolix/UniProtQA huggingface dataset:
Protein: RLMF_CITK8
Sequence: MSAQKPGLHPRNRHHHRYDLATLCQVTPELAQFLTRTPAGEQSVDFANPLAVKALNKALLAYFYQVANWDIPEGFLCPPVPGRADYIHHLADLLGETTGAIPADASVLDVGTGANCIYPLIGVHEYGWRFTGSEVHAQALASAQVIISGNPGLTRSIRLRRQKDPAAIFNGIIHKNEQYDATLCNPPFHDSAASARAGSERKRRNLGQDKNDALNFGGQQQELWCEGGEVAFIKTMIAESQAFGRQVMWFTTLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFMARKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_PARP8
Sequence: MELNNLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLGDLEKLPVDDIDLLALKQAGLIGEMMTSAKIIATGELKRKIVVKGLSATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GLGE_MYCTO
Sequence: MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVSAAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEPFVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLERAATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGVWVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHPIGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEVALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDEVLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGLAKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMFAIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQPFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEEATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAHIINMPAVPYESRNTLLRRR
What is the function of this protein?
Essential maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans.  Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP5 being optimal in the GlgE-catalyzed polymerization with M1P.  Is specific for the alpha-anomer of M1P as substrate, since the beta-anomer of M1P gives no activity.  Exhibits an alpha-retaining catalytic mechanism.  Is also able to catalyze the reverse reaction in vitro, releasing M1P from glycogen in the presence of inorganic phosphate.  Also catalyzes disproportionation reactions through maltosyl transfer between maltooligosaccharides.  Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity).
What are the official names of this protein?
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, GMPMT, (1->4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase, (1->4)-alpha-D-glucan:phosphate alpha-D-maltosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
Protein: GLUQ_CHRVO
Sequence: MSNALYRGRFAPSPTGLLHAGSLSTAIGSYLEARSRGGEWLLRMEDLDPPREVPGAADDILRTLEAFGFEWDGEVVYQSRRHGLYRAALERLIASGRAYACCCTRKEIAATARRGLDGYVYPGTCRNGCPDGREGRAWRLRVDEGEWTAHDRLQGEHRQDLARDIGDFVLLRADGFWAYQLAVVVDDAEQGVTDIVRGADLLVSTPRQLAVYDALGQSAPGYCHLPVLTNAAGEKLSKQTLAPAISTRDAARQLREALAWLGHVPPADCGSLDELWPWAVANWSLSRVPAGPLQLPLS
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: MIAA_FRAP2
Sequence: MNKLIYGLAGPTASGKTSLSISIANKINAEIISVDSSLVYKGMNIGTAKPTLDEQGDIKHHLIDIIEPTESFSVADFITNVNKLKKEIWSRGKEVLLVGGTMLYFKGLIEGLSSLPESQLEIRQTLELERKAKGLQYLHQQLNKMDQESAQKINPNDQQRIFRALEVIMITGKKYSELVKTSKVGGLEEQLKLCALVPNDRSILHNNIELRFKQMLDQGFLDEVQSLRKNPKLTKETTAIRSVGYRQAWEYLDGDISYEEFVKKGIVATRQLAKRQLTWIRNWQDEINLVEVENQNKEQQILEYFDYK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SY132_ORYSJ
Sequence: MNNLLTDSFELPRGGSSRDGDIEMGMQADPSDNLKGFLKKVDAIESLIAKLTNLLHKLQTANEESKAVTKARDMKAIKQRMEKDIDEVGKIARMAKTKVDELEKDNLSNRQKPGCGKGSAVDRSREQTTGAVKKKLKERMDDFQVLREAIRQEYRDVVERRVFTVTGSRPDEETVDNLIETGRSEQIFQEAIQQQGRGQILDTVAEIQERHDAVRDLERKLLELQQIFMDMAVLVDAQGDMINNIETHVSNATNHIQQGVSALQNAKKLQKNSRKWMCYAIILLLIIVVIIVVAVIQPWKKGA
What is the function of this protein?
Vesicle trafficking protein that functions in the secretory pathway (By similarity).  Required for plant growth and seed development (PubMed:35665185).
What are the official names of this protein?
Syntaxin-132, OsSYP132, OsSYP131a.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
Protein: REN_BGYMJ
Sequence: MDSRTGENITAHQAENSVFIWEVPNPLYFKIMRVEDPAYTRTRIYHIQVRFNHNLRKALDLHKAFLNFQVWTTSIQASGTTYLNRFRLLVLLYLHRLGVIGINNVIRAVQFATNKSYVNTVLENHDIKYKFY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, 15.6 kDa protein, Protein AC3, Protein AL3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: ARP7_ORYSI
Sequence: MEAVVVDAGSKLLKAGIALPDQSPSLVMPSKMKLEVEDGQMGDGAVVEEVVQPVVRGFVKDWDAMEDLLNYVLYSNIGWEIGDEGQILFTEPLFTPKALREQLAQLMFEKFNVSGFYDSEQAVLSLYAVGRISGCTVDIGHGKIDIAPVCEGAVQHIASKRFDIGGTDLTNLFAEELKKSNSSVNIDISDVERLKEQYACCAEDQMAFEAIGSSCRPERHTLPDGQVITIEKERYIVGEALFQPHILGLEDYGIVHQLVTSVSNVTPEYHRQLLENTMLCGGTASMTGFEDRFQREANLSASAICPSLVKPPEYMPENLARYSAWLGGAILAKVVFPQNQHVTKGDYDETGPSIVHKKCF
What is the function of this protein?
Essential protein required during embryogenesis and all plant development stages, probably through a chromatin-mediated regulation of gene expression.
What are the official names of this protein?
Actin-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the actin family. Plant ARP7 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SYE_STRS2
Sequence: MTKPIRVRYAPSPTGLLHIGNARTALFNYLFARHHGGTFLIRIEDTDRKRHVEDGERSQLENLRWLGIDWDESPETHENYRQSERLDIYQKYVDQLLAEGKAYKSYVTEEELAAERERQEAAGETPRYINEYLGMSEDEKTAYIAEREAAGIVPTVRLAVNEAGIYKWNDIVKGEIEFEGGNIGGDWVIQKRDGYPTYNFAVVIDDYLMKISHVIRGDDHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRRKGYMPEAVFNFIGLLGWNPGGEEEIFSREQFIQLFDENRLSKSPAAFDQKKMDWMSNEYIKNADLETIFNLAKPFLEEAGRLTDKAEKLVELYKPQMSSADEIVGLTDLFFSDFPELTAEEKEVMAGETVPTVLNALKEKLEAMTDEDFQPDNIFPQIKAVQKETGIKGKNLFMPIRIAVSGEMHGPELPNTIYLLGREKSIQHIDNMLKSL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_RUEPO
Sequence: MTSGRVNPQFRLEDQGIEGLGNVYYNFMEPALIEAALKRGEGTLGNGGAFLVTTGKFTGRSPKDKHVVKTASVADSIWWDNNAAMTPEGFDALYDDMLAHMKGKDYFVQDLVGGADPAYSINVRMVTELAWHNLFIRHLLRRPAREDLNEFVADFTVINCPSFQADPAKHGCRSETVIAMNFDRKLILIGGTEYAGENKKSVFTLLNYMLPEKGVMPMHCSANHAVGNPVDTAVFFGLSGTGKTTLSADPARVLIGDDEHGWSDRGTFNFEGGCYAKTINLNPEAEPEIYATTTKFATVIENMVFDEETKELDFDDDSLTANMRCAYPLEYISNASVSALGGHPKNIIMLTCDAFGVLPPIARLTPAQAMYHFLSGFTSKVAGTERGVTEPQPTFSTCFGAPFMPRRPEVYGNLLRDKIARHGATCWLVNTGWTGGAYGVGSRMPIKATRALLTAALNGSLNNAEFRKDGNFGFDVPVSVPGVAEVLLDPRRTWDDQGAFDKQAAKLVQMFADNFEQYVPYIDEDVKAVAIG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTC_BACCR
Sequence: MTGLIQNRDAFLDNIAKELGRARKTEGVERPVWKSNVNIETLKDYSQEELLEVFKKQCTNIHTTVVETTNDRLGEDLQKVIMENGGGPILLSADDRFDAYGLTSLFKEELPKRDVEVNVWDPERKDENMRLAEKANIGIAFSDYTLAESGTIVVQSHKGQGRSLHFLPTVYFAIIPRETLVPRITQAVQDMNSHVENGETAASCINFITGPSNSADIEMNLVVGVHGPLKAVYFIV
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: RL1_CLOB1
Sequence: MGKKYTESVKLVDKNTLYTVQEAIELVTKTSKAKFDETVELAVRLGVDPRHADQQVRGAVVLPHGTGKTVRVLVFAKGDKVNEAQEAGADFVGAEELVEKIQKENWFDFDVVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIADIKAGKVEYRVDKTAIIHVPIGKSSFGEEKLSDNFHVLMEAVVKAKPAAAKGQYIKSVAISSTMGPGIKINPGKVLE
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: SYA_SULIN
Sequence: MKASEEEYRLNFFIKNDFKRKICKSCKTPFWTRDEKKEYCSDIPCTDYYFFDINIKSQPLTVKEAREKFLSFFEKRGHTRISPKPVLARWREDLYLTIASIVDFQPHVTSGLVPPPTNPLVVSQPSIRLEDIDNVGITFGRHLTTFEMAAHHAFNYPDHYVYWKEETTAYATEFFTKELGIPEEELNFKESWWEGGGNAGPCLEVTVGGLELATLVFMQYKITDNGNYTPLKLKIVDTGYGVERIAWITQKTPSAFHAIYGNLVYKFFNKIGVAYIDETLLKVASRFAGKIDPDNPDTIKIHRQMVSKELGIDIKAVEEELDRAAKVFQILDHTKTIMLMLADGLVPSNSGEGYLGRLVIRRALKVLRLLKSDVRLYELVKEQIDFWKEDFPQVLKNKDYILDAVELEQQRFEKILEKVPSIASTLARKSEITTEDLIQVYDSNGIPPDLLEEELKKKSVKFELPRNFYALVAKRHQTSTIKSAYDKVKLPKDMLEYITALQPTEKLYYKDQYMRSFEGKVLGVYKNYLILDKTTFYPEGGGQLGDTGLIIDEKSSKRYEVIDTQKVNDVIVHILKEEPSTIKVGDNVRGEINWERRYRLMRHHTVTHVILAAAKKVLGEHVWQAGAEKTPEKGRLDITHHKTLTEEEVKLIENYANSVISDRRQVKPLEMNRMEAEMKYGVSIYEGGVPNSATIRLLEIKDWDIESCGGTHVSNTSEIGAVKIINVERIQDGVIRLEYVAGPALVDYIRETQAKIVEASKIIGTSPDQLTSRLRRILNEIEEKNNLIIQYRRIIETELLNNLKPYEINGNKIYIIEGLGDEEENKEILRKLTSTDNTIAISISDNRLQIATSKNMRVDKIVEELLKGGGKGGGKGTFANVILNSKKSKEEIIEIVIKSL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_BURO0
Sequence: MPLSNAQLAQTIDHTLLAPDASDAQIRELCRQAAEHRFYSVCVNSANVPLAARELAETGVLVCAVVGFPLGAGLSAAKAFEATAAIAAGAGEIDMVINLGALKSGRADDVKADIDAVHRACGTVPLKVILETGLLTDDEKVRVCEMCRDLGVAFVKTSTGFGHGGATLADVALMRRTVGPTLGVKASGGVRDRAAALAMLEAGATRLGTSSGVAIVTDQGGGAAGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
Protein: CXCR4_XENTR
Sequence: MDGFSGGIDINIFDSNSTENGSGDFEDFSEPCFMHDNSDFNRIFLPTIYSFIFLLGIIGNGLVVVVMGYQKKSRTMTDKYRLHLSVADLLFVFTLPFWSVDAAIGWYFKEFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLADKVVYAGVWLPALLLTVPDLVFARVSDENGQFVCDRIYPIDNRETWTVGFRFLHITVGLILPGLIILICYCVIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVCLTTDTFMLLGLLKADCIWENTLHKAISITEALAFFHCCLNPILYAFLGAKFKTSAQNAFTSVSRGSSLKILSKKRAGLSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine cxcl12/sdf-1.  Transduces a signal by increasing the intracellular calcium ion level.  Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation.  May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs).  May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, Stromal cell-derived factor 1 receptor, SDF-1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Early endosome. Late endosome. Lysosome. Note=Expressed in the cytoplasm of a small number of embryonic pPGCs from stage 24. Expressed in the nucleus of 3 lateral pPGCs (By similarity).
Protein: GUAA_STAAS
Sequence: MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCECKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RUVB_AROAE
Sequence: MIETDKLQAPRVISAQTADRQEDVVERALRPKRLAEYVGQAKIREQLEIFIQAAKNRHEALDHVLLFGPPGLGKTTLAHIVAAEMGVNLRQTSGPVLERAGDLAALLTNLEPHDVLFIDEIHRLSPVVEEILYPALEDFQIDIMIGEGPAARSVKLDLPPFTLVGATTRAGMLTNPLRDRFGIVARLEFYTPHELAYIVGRSAGLLDVAIDDAGAVEIARRARGTPRIANRLLRRVRDYAQVKADGDITAPVADAALLMLDVDHLGLDLMDRKLLGAMLEKFGGGPVGLDNLAAAIGESSDTIEDVLEPYLIQQGYLQRTPRGRIASASIWQHFGLAFPRRAGDESAELFSAP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: IL6_BOVIN
Sequence: MNSRFTSAFTPFAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPGRLLLTTPEKTEALIKRMVDKISAMRKEICEKNDECESSKETLAENKLNLPKMEEKDGCFQSGFNQAICLIRTTAGLLEYQIYLDYLQNEYEGNQENVRDLRKNIRTLIQILKQKIADLITTPATNTDLLEKMQSSNEWVKNAKIILILRNLENFLQFSLRAIRMK
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF.  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis.  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARNC_ESCF3
Sequence: MFEIHPIKKVSVVIPVYNEQESLPELINRTTAACESLGKEYEILLIDDGSSDASAQMLVEASQAPDSHIVSILLNRNYGQHSAIMAGFSYVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARQAVEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIATSGFSLAILLVVLRLAFGSQWSGEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYNDVRARPRYFVQKVIRPASSIDIEENH
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TM10A_HUMAN
Sequence: MSSEMLPAFIETSNVDKKQGINEDQEESQKPRLGEGCEPISKRQMKKLIKQKQWEEQRELRKQKRKEKRKRKKLERQCQMEPNSDGHDRKRVRRDVVHSTLRLIIDCSFDHLMVLKDIKKLHKQIQRCYAENRRALHPVQFYLTSHGGQLKKNMDENDKGWVNWKDIHIKPEHYSELIKKEDLIYLTSDSPNILKELDESKAYVIGGLVDHNHHKGLTYKQASDYGINHAQLPLGNFVKMNSRKVLAVNHVFEIILEYLETRDWQEAFFTILPQRKGAVPTDKACESASHDNQSVRMEEGGSDSDSSEEEYSRNELDSPHEEKQDKENHTESTVNSLPH
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765).  Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).
What are the official names of this protein?
tRNA methyltransferase 10 homolog A, RNA (guanine-9-)-methyltransferase domain-containing protein 2, tRNA (guanine(9)-N(1))-methyltransferase TRMT10A.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Protein: RL29_STRP8
Sequence: MKLQEIKDFVKELRGLSQEELAKKENELKKELFDLRFQAAAGQLEKTARLDEVKKQIARVKTVQSEMK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PANC_MARMS
Sequence: MKTFHTVAELRTALKIERLKDKKIVFVPTMGNLHDGHMSLIRKAKEEGDIIVSSIFVNPMQFSDQSDLERYPKTLEEDKRVLEANGCNYLFAPDALEMYPDGKRSQTQIEVVGISDILCGASRPGHFVGVSTVVTKLFNIVQPDTAIFGNKDFQQLKVIQDMVRDLSSNVRIIGVDTARNEDGLAMSSRNGYLTEEERRIAPTIYQTLLWAKEALLENRASHEDICEQAQQKLEAAGFRRDYFEIRAQENLQTPSEEEKRLVILTAAYLGKARLIDNLRVEL
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PHACI
Sequence: MTNLRKTYPIIKIINQPFIDLPAPSNILAWWNFGSLLGMCLMIQIITGLFLAMHYTPDTSTAFSSVAHICREVNYGWLIRNLHANGASVFFMCLYLHIGRGIYYGSYLYKETWNIGVILLLMTMMTALINYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVIVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDALGLALMLLILLLLALFSPDMLSDPDNFSPANPLNTPQHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILFMMPLLHTSKQRSLTFRPISQTLFWILVANLITLTWIGGQPVEQPFIIIGQVASISYFLLIIILMPLAGLFENYMLEPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KDSD_PSEAE
Sequence: MNMSQNLDFIHSAQRTIGLERDAVDSLLARIGDDFVKACELLLAGKGRVVVVGMGKSGHVGKKIAATLASTGTPSFFVHPAEASHGDMGMITKDDVVLALSNSGSTAEIVTLLPLIKRLGITLISMTGNPESPLAKAAEVNLDASVGQEACPLNLAPTSSTTVTLVLGDALAIALLEARGFTAEDFAFSHPGGALGRRLLLKVEDVMHVGEGLPQVLLGTSLTGALMEMTRKGLGMTVVLDEHGKLAGIFTDGDLRRALDRGIDVRQVTIDQVMTVHGKTVRAEILAAEALKIMEDNKIGALVVVDADDRPVGALNMHDLLRAGVM
What is the function of this protein?
Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs).  Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).
What are the official names of this protein?
Arabinose 5-phosphate isomerase KdsD, API, Pa-KdsD.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GutQ/KpsF subfamily.
Protein: TTC38_DANRE
Sequence: MICVVIMRHQAWQSDGLPLSSSSNEACKLYDAILSQYVTWRNDETLGGIEGCITSIKAADPDFVMGHVISTGLELVGTGSSVLRDERLASAVRRTVELADTQQLTSREKNHVKAVQLFSKGALHKACEVWECILADHPTDLLALKFAHDGFFYLGEQTQMRDSVARVMPHWKPHMPLYRQIKGMYSFGLLETRLYDEAEKMAKEALSLTPEDGWSVHAVAHVHEMKAEVEKGLNFMASTEKNWTVCDMLACHNYWHWALYHIEKGNYEAALKIFDEQVSQRCVKSGAMLDIVDSCSLLYRLELEGVSVGERYRELLQVTQPHSEDHTLLFNDLHFLMVSLGSKDTGTTQRLLESLQELAKDPAENRQLQIAERVGLPMCQALLEFEQRNYRQAVELLKPIKQSFVEIGGSDAQRDVFSQLLIHAAMKSGDKEHQQLARCMLMERDAVRPNSPLTDRLIQRAHSLHA
What are the official names of this protein?
Tetratricopeptide repeat protein 38, TPR repeat protein 38.
What is the protein family that this protein belongs to?
Belongs to the TTC38 family.