PharMolix/UniProtQA huggingface dataset:
Protein: RL1_SALPC
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFNESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGPNAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPSQAKGVYIKKVSISTTMGAGVAVDQAGLSASAN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RAP1_YEAST
Sequence: MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL
What is the function of this protein?
Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres.  RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences.  The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers.  RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres.  May also target the binding of RIF1 and RIF2 to silencers and telomeres.  Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
What are the official names of this protein?
DNA-binding protein RAP1, Repressor/activator site-binding protein, SBF-E, TUF.
What is the protein family that this protein belongs to?
Belongs to the RAP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: AZOR_MYCGA
Sequence: MSKVLFINASPVANEASFSYQLAKTFESEYLKLNPSDQVSWLDLNELDKGSMTLTSKNSKEHFKDENVDPLINQIKSVDKLVVIAPMTNFNYPATLKNWLDKICVANKTFSYKYSKKGGSIGLMDHLKVMIINTQGAPEGWYAFADVTVLLKGVFEFIGAMVDSIKVAGTKVEYLNKQPKEIVEPNLALIKEKAKNF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: GLBH_CAEEL
Sequence: MSMNRQEISDLCVKSLEGRMVGTEAQNIENGNAFYRYFFTNFPDLRVYFKGAEKYTADDVKKSERFDKQGQRILLACHLLANVYTNEEVFKGYVRETINRHRIYKMDPALWMAFFTVFTGYLESVGCLNDQQKAAWMALGKEFNAESQTHLKNSNLPHV
What is the function of this protein?
May be a globin and may play a role in oxygen transport.
What are the official names of this protein?
Globin-like protein.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SELA_CLOB1
Sequence: MDKKQLLRNLPKIDELLKEEIVNRYLQENSRTLVVDSLRQSIDYYRGEILKNNIDSFTKENVVNYFIDTLEENKSTKFKKVINATGVVIHTNLGRSLLAKEAIENVVKVSENYSNLEYDLKEGKRGSRYSHVEELIKKVTGAEAAMVVNNNAAAVMLALNTLCEEREAIVSRGQLVEIGGSFRVPDVMKFSRAHLVEVGTTNRTHLYDYENNINENTGVLLKVHTSNFKIMGFTEEVSSEEMVQLGGKYKLPVMEDIGSGTLVDFSKYGFTYEPTVQSSLEKGVDVVTFSGDKMLGGPQAGIIVGKKKYIDKMKKNQLTRALRIDKMTLAALEGTLKCYIDEKEAIENIPTLNMILSSKDIHKKRAQRLKRRLQNNVKDFNFKVSEDLSMVGGGSMPGERIPTYVVKVNSDKITAEKIEEKLRLSKNPIIVRVSKDEVILDVRTLFERDFNIIVEEFKKLLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_NOCSJ
Sequence: MTATIEETQETGSAGVGRIARVIGPVVDVEFPVDSMPEIYNKLECELTLEGEAKILSLEVAQHIGDGMVRAISLQPTDGLVRGAQVTDTGGPITVPVGDATLGKVFNTLGEVLNLEEGETFEVKERWGIHRKAPAFDQLESKTQMFETGIKVIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIARVAKDHGGVSVFAGVGERTREGNDLIVEMEEAGVIGQTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGTLQERITSTRGHSITSMQAIYVPADDYTDPAPATTFAHLDATTELSREIASLGIYPAVDPLTSTSRILDPQYIGQAHYDCAIRIKQILQRNKELQDIIAILGVDELSEEDKIIVSRARRIQRFLSQNTYVAKQFTGIEGSTVPVSETIEGFNKIADGEYDHVAEQAFFMCGGLDDVEQKWAEIQKSL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ILVD_METKA
Sequence: MRSGDIKEGVERTPHRALLRACGLTDEEMDRPFVAVVNTYSEVVPGHMHLDKVTEAVKAGIRMAGGVPFEVETIALCDGIAMNTPGMKYSLPSRELVADTIETVIEAHRFDGFVAIVSCDKMVPGALMAAARLDLPAAIVTGGPMEPGCVDGERVDLIDAFEAVGAYEEGEISEEELEELEQRACPGPGSCAGMFTANTMACMTEVLGMSEFNCAATPATEAEKLRVAKLTGMRIVEAIEEGITARDVLTREAFLDAIRVDMALGGSTNTVLHLLAIAREADVELSLDDFDELSRETPHLCAMRPGGPYTMRDLYEAGGVPAVMKELADDLHLDRIDFAGRSMRERVERTEVKDREVIRPKEDPVHEEGGIVVLYGNLAPKGAVIKTAALSEEMYEHEGPAVVFDSEEEATEAILGGDIDPGDVVVIRYEGPAGGPGMREMLTPTAALCGMGLDDSVALVTDGRFSGGTRGPCVGHVSPEAYRGGPIAVVEEGDTIRLDVRERRLEVDVEDEELEARLEEWEPPEDEVTGYLRRYRELVRGADEGAVLR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PDXS_LISW6
Sequence: MEKKVGTDRVKRGMAQMQKGGVIMDVVNAEQAKIAEDAGAVAVMALERVPSDIRAAGGVARMADPRIVEEVMNAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADDEFHLLKSDFTVPFVCGCRDIGEALRRIGEGAAMLRTKGEPGTGNIVEAVRHMRQVNGQIRQIVGMTDDELMVAAKNFGAPYELVKEIKSLGKLPVVNFAAGGVATPSDAALMMELGADGVFVGSGIFKSDNPAKFASAIVQATTYYTDYELIGKLSKELGSPMKGIEMSRLNPEDRMQDRSV
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: DHA2_STAAW
Sequence: MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
What is the function of this protein?
May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
What are the official names of this protein?
Alanine dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: DGTPH_BPSHA
Sequence: MSGNKFDQEKVDLHVLDPFFIEGTARVAQFGEQKYGRSNWMQGLTQTRIINAIKRHIAQIEKGEDIDEESGFHHAYHAAWGCQVLAYQHRNGQTHLDDRRWSESVRDADTKIGTCEGISGHTVPCMYEGPFGRLHPVDGEKDGLVMSFVQSEADEGTAQGDPIQQLQQMISEWADQVYPDRTVENALTKMMLHEIPELLHGKAMDPAEFADVAILLFDVAHLQGIDIAQAMREKMEINQARDWKIDPATGLMSHVKPKGMMETIRDAVQGIGDAARIMAAPSRLLNGNNMELAEYTAETLPKPPEKPWEITIPNWALKTEEGTHIKLRAGSGVFGRVKYQSQCILMHKNMRKRSHLETYYCATIKDTVTEDEYNVPWSEIEPWTN
What is the function of this protein?
Catalyzes the hydrolysis of dGTP into dGMP, which is needed among other for the first step of biosynthesis of dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate).
What are the official names of this protein?
dATP/dGTP diphosphohydrolase, dATP/dGTP pyrophosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Caudovirales dATP/dGTP diphosphohydrolase family.
Protein: Y3852_ARATH
Sequence: MADNIDLELSLQTNHSMIINKRLTQSDVDYNNRLHLPKREFEQFILPEMEWELVMNLRNSVEVIVKDVNGNEYHVTLVKYQNGHYYFMGKWMDIVRAKGYKRDDEISLLWDKSNEVFYII
What are the official names of this protein?
Putative B3 domain-containing protein At3g28853.
What are the subcellular locations of this protein?
Nucleus.
Protein: KYNB_BURP0
Sequence: MDTIWDISPPIAPATPVWPGDTPVGIERVWRIEAGSPVNVARVTLSPHTGAHADAPLHYDADGAPIGAVPLDAYLGRCRVIHCIGARSAVTPEHVRAALAGAPPRVLLRTYGQAPQHAWDSAFCAVAPETIDLLAAHGVRLVGIDTPSLDPQESKTMDAHRRIRAHRMAILEGLVLDEIAAGDYELIALPLKFATLDASPVRAVLRALPDAPR
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: RS20_DECAR
Sequence: MANSAQARKRARQADGQRSHNASLRSTLRTAIKRVRQAIEAGDKAAAQGVFQQSVAVLDRIADKKIVHKNKASRTKSRLSAQIKALAAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CA213_HUMAN
Sequence: MLAVPVRLKVGSRKPEWGTNRLTSCPAKDPLDRRLQNLRDRERVPEPQRSLRPGVQEDSREHGQVPEVSDPQVDLEFVDLQAKPRYRRLILKTQIPEASDSQAAQKPQAHRQIPETTEAGRETTSN
What are the official names of this protein?
Putative uncharacterized protein ZNF436-AS1, ZNF436 antisense RNA 1, ZNF436 antisense gene protein 1.
Protein: OVO_DROME
Sequence: MPKIFLIKNRLHQQQQRLLESQNLLQHKNQDDERLVPPLSPSGSGSGPSPTPTSQPPPEPQGQGQQVLGQVPDSDQQPLSLTRKRFHHRRHYFGQSRHSLDHLNQNQSPNPNANANPNQIQNPAELEVECATGQVQNENFAAELLQRLTPNTATTAQNNIVNNLVNNSRAATSVLATKDCTIENSPISIPKNQRAEDEEEQEDQEKEKPAEREREKSDERTEQVEKEERVEREEEEDDEVDVGVEAPRPRFYNTGVVLTQAQRKEYPQEPKDLSLTIAKSSPASPHIHSDSESDSDSDGGCKLIVDEKPPLPVIKPLSLRLRSTPPPADQRPSPPPPRDPAPAVRCSVIQRAPQSQLPTSRAGFLLPPLDQLGPEQQEPIDYHVPKRRSPSYDSDEELNARRLERARQVREARRRSTILAARVLLAQSQRLNPRLVRSLPGILAAAAGHGRNSSSSSGAAGQGFQSSGFGSQNSGSGSSSGNQNAGSGAGSPGSGAGGGGGMGGGRDGRGNYGPNSPPTGALPPFYESLKSGQQSTASNNTGQSPGANHSHFNANPANFLQNAAAAAYIMSAGSGGGGCTGNGGGGASGPGGGPSANSGGGGGGGGGNGYINCGGVGGPNNSLDGNNLLNFASVSNYNESNSKFHNHHHHHQHNNNNNNNGGQTSMMGHPFYGGNPSAYGIILKDEPDIEYDEAKIDIGTFAQNIIQATMGSSGQFNASAYEDAIMSDLASSGQCPNGAVDPLQFTATLMLSSQTDHLLEQLSDAVDLSSFLQRSCVDDEESTSPRQDFELVSTPSLTPDSVTPVEQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQQQQHHQQHGVQQQQQQQHSVQQQQQHNVQQQHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQAAIMSQQQQQLLSQQQQQSHHQQQQQQQHAAAYQQHNIYAQQQQQQQQQHHQQQQQQQHHHFHHQQQQQPQPQSHHSHHHGHGHDNSNMSLPSPTAAAAAAAAAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVNGGHGIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNSSASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECGHTTCEPEVHYLHLKNNHPFSPALLKFYDKRHFKFTNSQFANNLLGQLPMPVHN
What is the function of this protein?
Transcriptional activator which is specifically involved in female germline development, where it functions antagonistically to isoform C (PubMed:10648246, PubMed:1712294, PubMed:3428601, PubMed:8652413).  Necessary and sufficient for normal oogenesis (PubMed:1712294, PubMed:12051822).  Required in the primordial germ cells (PGCs) for normal development of male and female germline cells (PubMed:28059165).  Plays a role in germline sex determination (PubMed:2116356).  Binds the promoter DNA and positively regulates the transcription of the otu gene in a stage-specific manner (PubMed:10525184, PubMed:11290304, PubMed:9634487).  May have autoregulatory activity (PubMed:11290304, PubMed:9634487).
What are the official names of this protein?
Transcriptional regulator ovo, Transcriptional repressor shavenbaby, Transcriptional repressor svb.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Transcriptional activator shavenbaby]: Nucleus, nucleoplasm. Note=Diffuse nucleoplasmic distribution. SUBCELLULAR LOCATION: [Isoform B]: Nucleus. Note=Localizes to the nuclear foci. SUBCELLULAR LOCATION: [Isoform C]: Nucleus. Note=Localizes to the nuclear foci. SUBCELLULAR LOCATION: [Isoform D]: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Note=Diffuse nucleoplasmic distribution (PubMed:20647469). Expressed in germ cell nuclei throughout oocyte development (PubMed:7748792). Not expressed in nuclei of stage 9 oocytes but is expressed in nurse cell nuclei (PubMed:7748792). In stage 12 oocytes it is also detected in the ooplasm (PubMed:7748792).
Protein: CU5A_CONCL
Sequence: MRFYIGLMAALMLTSILRTDSASVDQTGAEGGLALIERVIRQRDAADVKPVARTNEGPGRDPAPCCQHPIETCCRR
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal5a L1.
Protein: RNH_KLEP3
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAIMRYRQHEKTFSAGYRLTTNNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKGHAGHPENERCDELARAAASHPTQDDIGYQPES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_MARSD
Sequence: MKRIVLTTGGTGGHVFPALAVAHEIKNRFPQCEILFIGGKGPEREMVERAGISFKGLPAKGVLGGGIKKVFSSLWIVSAMIMALKEIASFKPDAVIGFGGYAGFCPVLAAWLLGVPTAIHEQNSVPGVTNRILGKVVKRVFASFEDRNGSFPAAKTVVVGNPVRKEIIDSGNCADTKTVLVFGGSQGAAAINDAVIDGLAKLKEAGISLRHQTGKADFEKVRKGYEQNGMDTGKVSPFIHNMGEAYAEASLVVCRAGASTVFEVAAAGKPAIFIPFPHATHDHQTGNARSLADLGAAELIPQAELGGNRLADEIIKLIADQDRLKGMGSKALSFARTDAASAIAEGVGDIIRMKTVRGAA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNJB9_RAT
Sequence: MATPQSVFVFAICILMITELILASKNYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANRRKEYDIIGHSAFTNGKGQRSNGSPFEQSFNFNFDDLFKDFNLFGQNQNTRSKKHFENHFQTRQDGSSRQRHHFQEFSFGGGLFDDMFEDMEKMFSFSGFDSTNRRTVQTENRFHGSSKHCRTVTQRRGNMVTTYTDCSGQ
What is the function of this protein?
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity).  J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity).  In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity).  Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins.  Required for survival of B-cell progenitors and normal antibody production (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily B member 9, Endoplasmic reticulum DNA J domain-containing protein 4, ER-resident protein ERdj4, ERdj4, Microvascular endothelial differentiation gene 1 protein, Mdg-1.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: E1128_IXORI
Sequence: MFIALGIQLFVAVTYAAGKDDEHFSVDYCGMNCTQQEDGSWTACSGRNEECRCYHESGKKNGLCLSTTYIDFSQYGNPSDSDIAAASPRP
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8.
What are the official names of this protein?
Evasin P1128.
What are the subcellular locations of this protein?
Secreted.
Protein: V1R42_MOUSE
Sequence: MGDILFSSPQSMFSHTMNKNSILHTHSIIGKTFFSEIGIGISGNSFLLLVHILKFIRGHRPRLTDLPIGLLSLIHLLMLLVAAFIATDIFISRRGWDDIICKFLVYLYRVLRGFSLCTTSMLSILQAIILSPRSSCLAKFKHISPHHISGAILFLSVLYMLIGSQLLVSIIATPNLTMNDFIYVTQSCSILPLSYLMQSIYSTLLAIREFFLISLMVLSNWYMVALLSMHRKQTQHLHGTNLSPKKSPEQSATQTILMLISFFLLMTIYDTIVSCSRTMFLNDPTSYSIELFIMHIYATVSPFVFMSTEKHIVNFLRSLGKRVINFNLH
What is the function of this protein?
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
What are the official names of this protein?
Vomeronasal type-1 receptor 42, Vomeronasal type-1 receptor A1, Vomeronasal type-1 receptor A10, Vomeronasal type-1 receptor A3, Vomeronasal type-1 receptor A6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FBX3_MOUSE
Sequence: MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDADENESDEGEGEARRRRVFDVPIRRRRCSRLF
What is the function of this protein?
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity).  In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity).  PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).  The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:23542741).
What are the official names of this protein?
F-box only protein 3.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
Protein: NU4LM_DIDVI
Sequence: MVLIKLNIIVAFMLALSGVLIYRSHLMSTLLCLEGMMLSLFIFMAAMITHFHMFSISMMPLILLVFSACEAGVGLALLVSISNTYGNDQVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: THII_STRPB
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAIAVRSDRDRTHVSLNGTDYQPIVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASCC2_DICDI
Sequence: MQQQQQPKVKLSKKDYIEKKEKEQQLLNNNNKVNREKDGKIMIEKNLQEKQDDILMNEKKKQQSGLGIDKTFTLVINTLGHLEKKNDLDQYWVLNNKEYHLSFITFLPADNNEQGSSEESILFMNSDLSSLLKFQYNIFWSHCIFNKSLNEFIDSFLKFFKRDNQPIISLVNNNSVNNNNNNNNSIIKKGSKDFNESKKLLFKRVFLVLVRMSLQQEKSGFITREFYSDLIYKNKLFTIPKLFDIVSLYSSHARDAVTTMIQSIFDTQPNYYKDLLQHFQLISKTLFELNQSLLNRNLLDLLRLEDNYLMDIVYNLEQFIRIFPMGSHQLFDEYLMNLEKGGGDGNGGVLGWLTYFYEYIIPIFNKENQKASNKQVNLTPSIYVPLKQHILSIFHTIFRHHFMIKLEQLQLLIQDPCQLCKKLPLDEISHRFFSLLGNITSFSQQIIGSTKSNRSKLFNEYFDNITSASILYDYEQTYKLSNFLDKLVTLDSSIDFTSYTYFMQLIGKPVSQDQKQIQKPKFKKSTTIIDSNISSSSSSSSSSSPSNATTTVKPILSNNPVIMNTVKIDQVKSLFPDLGDWFVHCCLKYYNQDVEQVINALCDDSSLPPHLKSMDRSLSSDPSQPSKNIPTPTTTTTTTTTTDKPNNTTTATTTTTTTTSSSKSLEKSMNELNISIGYEKIYDEKYDDSLEEFSGFSVQDGEKYNDEDEDEKKDSENNTNTEDQKHPTTSASGRTPNESNNLGRPRQNNPNKGRKEDNRNNKQQTHSSHHSQPQQQQQQQPPQHQPQPHQQPQQQPQPHQHQQPQQQQPQQPQHKQQPKPQQSKQHPQQQPKQQPKQQPQQPKQQSQQQPKQHPQPQQPQQPQPQPQPQPQQQQQQQQQQQQQQQQRQPQQPQQPQPQQQNQQQNQQQNQQPKKSQNDDKPKPDKKPKGSYSKGGSVGGGR
What is the function of this protein?
Enhances NF-kappa-B, SRF and AP1 transactivation (By similarity).  Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity).
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ASCC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBFA_LISIN
Sequence: MNVRANRVSEQMKKELGDILNRKIKDPRLGFVTVTGVDVTGDLQEAKVFISILGTDKEKENTLLALEKAHGFIRSEIGRRIRLRKVPEMSFEIDNSIAYGNRIDELLRDLNNDQ
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.