PharMolix/UniProtQA huggingface dataset:
Protein: FABZ_SHESM
Sequence: MSNQMNTMDITEILKYLPHRYPFLLIDRVLDYTPGESLHAIKNVTINEPFFQGHFPVQPVMPGVLILEAMAQATGLLAFKTMSDDVPPPGVLYYFAGIDNARFRRVVEPGDQIHFDVKMIKERRGIGVFYGEAKVDGEVVCSAEIMCARREINQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_XANCP
Sequence: MTPRLRLQPESVGIGMTSQRVRDRLVERLRESGIQDEATLNAVRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVVARMTEAVLQVAPKKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIVVTAAAPALVDALVDQLAVGGRLVAPVGGASSQSLVQLTRGADGEIAQEVLAPVTFVPLLSGMLD
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGI_PSEE4
Sequence: MFNARRLIAATLLMSCAFGAHAERLKDIASISGVRANQLIGYGLVVGLNGTGDQTTQTPFTLQTFNNMLSQFGIKVPPGSGNVQLKNVAAVSVHADLPPFAKPGQVVDITVSSIGNSKSLRGGSLLMTPLKGIDGNVYAIAQGNLVVGGFDAEGRDGSKITVNVPSAGRIPGGASVERAVPSGFNQGNSLTLNLNRPDFTTAKRIVDKVNELLGPGVAQAVDGGSVRVTAPMDPSQRVDYLSILENLEIDPGQAVAKVIINSRTGTIVIGQNVKVSPAAVTHGSLTVTITEDPIVSQPGPFSNGQTAVVPRSRVNAQQEAKPMFKFGPGTTLDEIVRAVNQVGAAPSDLMAILEALKQAGALQADLIVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: DAPA_MYCBT
Sequence: MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSIB_SALTY
Sequence: MTQFITHKWLAALGLASSIAAFPALAAKDVVVAVGSNFTTLDPYDANDTLSQAVAKSFYQGLFGLDKDMKVKNVLAEGYTVSDDGLTYTITLRQGVKFQDGADFNAAAVKANLDRASNPDNHLKRYNLYKNIAKTEVVDPATVKITLKQPFSAFINILAHPATAMISPQALEKYGKDIGFHPVGTGPYQLETWNQTDFVKVKKFAGYWQQGLPKLDSITWRPVTDNNTRAAMLQTGEAQFAFPIPYEQAALLAKNKNLELVASPSIMQRYISMNVTQKPFDNPKVREALNYAINRQALVKVAFAGYATPATGVVPPSIAYAQSYQPWPYDPAKARELLKEAGYPDGFSTTLWSSHNHSTAQKVLQFTQQQLAQIGVKARITAMDAGQRAAEVEGKGQKESGVRMFYTGWSASTGEADWALSPLFASQNWPPTQFNTAFYSNKQVDSDLAAALKTNDPQEKTRLYKEAQDIIWKESPWIPLVVEKLVSAHSKNLTGFWIMPDTGFSFDDADLK
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Binds glutathione.
What are the official names of this protein?
Glutathione-binding protein GsiB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AACC3_PSEAI
Sequence: MTDLNIPHTHAHLVDAFQALGIRAGQALMLHASVKAVGAVMGGPNVILQALMDALTPDGTLMMYAGWQDIPDFIDSLPDALKAVYLEQHPPFDPATARAVRENSVLAEFLRTWPCVHRSANPEASMVAVGRQAALLTANHALDYGYGVESPLAKLVAIEGYVLMLGAPLDTITLLHHAEYLAKMRHKNVVRYPCPILRDGRKVWVTVEDYDTGDPHDDYSFEQIARDYVAQGGGTRGKVGDADAYLFAAQDLTRFAVQWLESRFGDSASYG
What is the function of this protein?
Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin and neomycin, but not to amikacin or netilmicin (PubMed:1649572).  Acetylates a broad range of both 4,5- and 4,6-disubstituted aminoglycosides, including neomycin, paromomycin, ribostamycin, sisomicin, gentamicin, tobramycin and kanamycin, with no preference of one disubstitution over the other.  Acetylates sisomicin and kanamycin most and least efficiently, respectively.  Does not modify plazomicin (PubMed:35921328).
What are the official names of this protein?
Aminoglycoside N(3)-acetyltransferase III, AAC(3)-IIIa, ACC(3)-III, Aminocyclitol 3-N-acetyltransferase type III, Aminoglycoside acetyltransferase (3)-IIIa, Gentamicin-(3)-N-acetyl-transferase.
What is the protein family that this protein belongs to?
Belongs to the antibiotic N-acetyltransferase family.
Protein: LIGB_ECOUT
Sequence: MKVWMAILISILCWQSSAWAVCPAWSPARAQEEISRLQQQIKQWDDDYWKEGKSEVEDGVYDQLSARLTQWQRCFGNETRDVMMPPLNGAVMHPVAHTGVRKMADKNALSLWMRERSDLWVQPKVDGVAVTLVYRDGKLNKAISRGNGLKGEDWTQKVRLISAVPQTVSGPLANSTLQGEIFLQREGHIQQQMGGINARAKVAGLMMRQGNSDTLNSLAVFVWAWPDGPHLMTDRLKDLATAGFTLTQTYTRAVKNADEVAHVRNEWWKAKLPFVTDGVVVRAAKEPESRHWLPGQAEWLVAWKYQPVAQVAEVKAIQFAVGKSGKISVVASLAPVMLDDKKVQRVNIGSVRRWQEWDIAPGDQILVSLAGQGIPRIDDVVWRGAERTKPTPPENRFNSLTCYFASDVCQEQFISRLVWLGSKQVLGLDGIGEAGWRALHQTHRFEHIFSWLLLTPEQLQNTPGIAKSKSAQLWHQFNLARQQPFTRWVMAMGIPLTRAALNASDERSWSQLLFSTEQFWQQQPGTGSGRARQVIEWKENAQIKKLGSWLAAQQITGFEP
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: SURE_ACTPJ
Sequence: MNILISNDDGYHAQGIQTLAETLRDAGHSVTVIAPDRNRSAASSCLTLMEPIRVHQLDEFNYAVIAGTPADCVHLALNGFFEQSFDLVISGINHGANLGDDVVYSGTVAAALEGRHLPYPSLAISLVGRKSEGHLFGNNHFDTAAKVVLDLLPKVQKGIVPARQILNINVPDLPYEQVKGVMITRLGHRSPAAEIVKREDPRGATIYWLGANGVPVDASEGTDFYALAHNYVSVTPIQADMTAHYSIQALKDTF
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUD23_BOVIN
Sequence: MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKPGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLVRGGRAVLQLYPENSEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSTSLPEGLSEDTEEEKPAESTFTADRIPYRIARRGVVRKSREWVLEKKARRRRQGKEVCPDTQYTGRKRKPRF
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA.  Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity.  Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.  Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity.  Locus-specific steroid receptor coactivator.  Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors.  Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements.  Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.
What are the official names of this protein?
Probable 18S rRNA (guanine-N(7))-methyltransferase, Bud site selection protein 23 homolog, Williams-Beuren syndrome chromosomal region 22 protein homolog, rRNA methyltransferase and ribosome maturation factor.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Cytoplasm. Note=Localized diffusely throughout the nucleus and the cytoplasm. Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. Localization is not affected by glucocorticoid treatment.
Protein: NDK_STRCO
Sequence: MTQRSLVLLKPDAVRRGLTGEIISRIERKAGWQITALELRTLDTETLEQHYGEHKGKPFYEPLVEFMASGPVVAMVVEGERVIEGVRALAGPTDPIAAAPGSIRGDYGVIVRENLIHASDSEESAERELKIFFPGRV
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF2_THEON
Sequence: MGRREEMIAKIKELMTQPERIRNMGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQARGITINAANVSMVHTYEGKEYLINLIDTPGHVDFGGDVTRAMRAIDGAIIVVDAVEGVMPQTETVLRQALREYVKPVLFINKVDRLIKELKLGPNEILNRFAKIITDVNRLIKRYAPEEFKNQWLVKVEDGSVAFGSAYYNWALSVPYMKRTGVTFKDIVELTNAGDLKTLRQKAPLHVVVLDMVVRHLPNPLEAQKYRIPHLWRGDINSDVGQAMINCDPKGKMVMVVTKIILDKHAGEVATGRVWSGTVKTGQEVYLINSKRKARIQQVGIYMGPERVNMEAVQAGNIVAVTGLRDAMAGETVSVEQIEPFEALHYTSEPVVTVAIEAKNVKDLPKLIEALRQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVKLYRLKTEWKLDVDVSPPIVVYRESVTKQSPIVEGKSPNKHNRFYITVEPLPDAIYEAIREGEIPEGRPKDPKAVAKKLAELGLDYEIAKGIVDVYNGNIFLDNTKGIQYLNEVMDLLVDGFHQAMDEGPLAKEPVMKVMVRLHDAKIHEDNVHRGPAQIYPAIRTAIHCAMMKAGPVLYEPYQKVIINIPYEYMGSVSREINQRRGQLIDMRQEGEVMIIISEAPVAEMFGFAGALRGATSGKALWSTEHAGFKRVPNELAVNIIRQIRQRKGLDPNPPKEQDVCPQQ
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTN1_SCHPO
Sequence: MSEQHSLNPFESGSVTASDVAAAKSGAEDLVNTLTAHTVHPSTELPSATSFPSALPNSENPVIQNISSSSSEPHHTSQSTPGETSSPVCPVSGAHGGADKKCPALEAGCPFTNTTKQNVDPEISNALWSVLTWKNTSCSFSTLMSILALVYVPSWINLPRLFFRTFRYVFLITSIIEFGGLFASNGKRGVLSHFRSSYITCDSKALDRIVNSIVDIFNVMLIQFQRILFAESPILTFTASVAAFIEFFLSGFLSYKSLFVWNVLFAFILPRLYVCNERSIKHLVASLERSGDKLKKQATETINTTVNK
What is the function of this protein?
Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator.  Overexpression causes cell lysis.
What are the official names of this protein?
Reticulon-like protein 1, Cell lysis protein cwl1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Enriched at the cell equator during mitosis.
Protein: RLMN_LEGPH
Sequence: MDQQKVNLLNYNYSQLRELLIAWDEKPFRAQQLFQWIHQVGIRDFAQMTNLGKVLRNKLSQLACIDLPEIVACQKSADGTHKWLLKLECGNCIETVFIPEANRGTLCVSSQVGCALNCSFCSTAKQGFNRNLSTAEIIGQVWLAARELSDNNGTHDKKITNVVMMGMGEPLLNFDNVVSAMNIMMDDLAYGLSKRRVTLSTSGVLPEMERLREVSPVALAVSLHAPTDELRNELVPINKKYPLSQLISLCKRYFKDEPRRKVTFEYVMLKGVNDQPEHASQLIKLLHNVPAKVNLIPFNPFPLTQYQRSSRETIDAFRDKLMKHGINTITRKTRGDDIDAACGQLAGEVKDKTSRSQRWQKLHFMSKTDKSTELTISSEEIA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_YERPB
Sequence: MKKGVLLNADISAVISRLGHTDQIVIGDAGLPIPATTTRIDLALTRGVPGFLQVVDVVTQEMQVENAYLAEEIVKNNPQLHEALLVLLTQLEQRQENQIALRYISHEAFKEQTKQSRAVIRSGECSPFANIILGSGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_ACIB5
Sequence: MTVQTFIPNGAKAASENTVTQPTHTTDVSIKKLYIETQGCQMNEYDSHRMADLLGDSHGYVLTNNPNEADILLMNTCSIREKAQEKVFSELGRWRKLKEQNPDLVIGVGGCVASQEGDNIQKRAPYVDMIFGPQTLHRLPQMLDQHHAQVEKPKKEKIKLVDISFPDIEKFDFLPEPRVEGFKAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLAEIAGLAEKGVREISLLGQNVNGYRGETFEGGICTFPELLRLVAEIPGIGRLRYTTSHPLEFSDELIQCYEDLPQMVSHLHLPVQSGSNDVLKAMKRNHTIDVYIDKIAKLRKIRPDMHLSSDFIIGFPGETDENFAETLQFIKDLDFDHSYSFVYSKRPGTPASDLPDTTPEHVKKERLAQVQQVIKQSSIEKTDAMLGKIERVLIEKVSDQDPNILVGTADNTRLVTFVGDASWVGRFAEIEITEIKTLNLVYGELLNLEPDVA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DML1_CANGA
Sequence: MHEVITISVSQRANHLATQFFNCRETLLYDNTKDKVNDPKIFLNPTIDRISKTVSYSPRALLWDAKTGNGSLGSYQYSDGSDYYFKNDDDKPSDGDLMQTHPVIPKSDYQRALDAGLPEPKLNNSNTKYWSDYARLIYQPSSFNILRDWYHDTDNPNRPDFKSLKDRRFDKFIIGEEEFKSNYLVDFFDTNLHHELEQCDTLQGFNIITDIDNGWGGFSSALLVELRNELPKNTYFSWAFHESDPYTVSYTRNTKVQFNKKTAEQISNKIRATTSLSQESDLFIPVYSDPEYSNWEIGSLVCPLFDGLNSVLDGTDTEKRRNMQYLSELLQNGDNNRKIISSANMIRKDRIIDYLYYSRFPTQSRKSSSAVSEFHVFSKCNISRSNKEMKDNAEIKNVTNKQINTYGYKFADTVSDQFKEDSNYKLCLTSDERCRNVFKEYGDFVSKYIKYDDDREDMKNSLENTASAYEFGWYDDSDSGDDNY
What is the function of this protein?
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
What are the official names of this protein?
Protein DML1.
What is the protein family that this protein belongs to?
Belongs to the misato family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GATA_METBF
Sequence: MAKWMSVAQVKEKIKESSAEEVTAQYLDTIGKSKVNGYITVSEKALEQAKKIDVEGHNGPLAGVPIAIKDNISVVGLPNSCGSKILEDYIPPFNAYVIEKLLAAGAVILGKTNMDEFAMGSSTETSYFGPTANPWDLERVPGGSSGGSAAVVAAGEAPFALGSDTGGSVRCPAAFCGVVGLKPTYGAVSRYGVVAYANSLEQVGPLANNVTDIAVLMDVIAGYDRKDSTSIDSKTEYQKALIEDVKGLKIGVPKEFFGEGIHPDVEKAVWNAIHKCEDLGASWEEVSMPHIKYALASYYIIAMSEASSNLARFDGTRYGYRASGENWHAMVSKTRAEGFGTEVKRRILLGTYALSAGYHDKYYLKALKVRTLVKQDFDKALSKVDVLMAPTMPNPAFKIGEKIEDPLTLYLSDVNTCPINLAGVPSLSVPCGFTDGLPIGLQIMGKPFDEPAVLRAAYTFEQNTDYHTKRPPEVA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: CSOS2_HYDCU
Sequence: MSTSNAQSGRAAAIARRNAQVKGKGYTASAAPAAPRKPAAPVAEPVVAAAPAPSQPSRSRRKVSVAPTATPAASAAGREAAKLKRQQQKNGKSSAGAANAMPHPKAKAKQKPEEPIVEPRQAKAEKPTKRSERRTGVKPQVASQQPSGRLQSKAYRKAQAKGKAGQEAFKSNGSSQSGAKAKLANPDASTREIAQQVRAERCAQGKTCSTGGSRPMRKRRNAKEAPQKVGESQTLHGQSVSGTQVGQGEKKMTGSESGACQLVSGTEYLGAEEFSKNCDVQPTPQPAKVTQTQTTRGQVVSGSTKVGRSDKMTGNETGTCSAITGTEYLPADQSKMYCGETPAKSKATGFSVMSQATQKSEQKVTGGDSRKSQSTTFKPKNPASAPHKVMPSQTAKGNTTTGSQVGRLESVTGGERGSCHAVTGTGYQGAEEAKACDMPMTETADKVTASGTAGGQKVTGDRSGAYYGMTGAEAGDCKTITGTSYTGTEQFQFCSVDEQNEMKVRQRKGANPSISGVQPGPQGLTGAQKGACELVTGSHYQGGDQTAMVCDSTNAAAPGESDFPAMIGQAQPAFSTNEVEPMVDEGSKITGDGWDRGSKVTGTDGPWAAQRNASIRGVAGQSPMGASQYRPVNNEVPMSPITGSSGNTDTGAKVTLSGGARA
What is the function of this protein?
Required for alpha-carboxysome (Cb) assembly, mediates interaction between RuBisCO and the Cb shell.  The protein is probably intrinsically disordered.  The C-terminal repeats act as the encapsulation signal to target proteins to the Cb; they are necessary and sufficient to target both CsoS2 and foreign proteins to the Cb.  The N-terminal repeats of this protein bind simultaneously to both subunits of RuBisCO.  Probably also interacts with the major shell proteins (CsoS1); that interaction would increase the local concentration of CsoS2 so that it can condense RuBisCO and full carboxysomes can be formed.
What are the official names of this protein?
Carboxysome assembly protein CsoS2, Carboxysome shell protein CsoS2.
What is the protein family that this protein belongs to?
Belongs to the CsoS2 family.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Protein: ACSM1_MOUSE
Sequence: MQWLKSFQICKVLQGFSLSPTQLHRRLFSRVGAPRWNDHDSPEEFNFASDVLDYWAQMEEEGKRGPSPAFWWVNGQGDEIKWSFRKLRDLTCRTANVFEQICGLQQGDHLALILPRVPEWWLVTVGCMRTGIIFMPGTTQLKAKDILYRIQISRAKAIVTTASLVPEVESVASECPDLKTKLVVSDHSHEGWLDFCSLIKSASPDHTCIKSKMKDPMAIFFTSGTTGYPKMAKHNQGLAFRSYIPSCRKLLKLKTSDILWCMSDPGWILATVGCLIEPWTSGCTVFIHHLPQFDPKVIVEVLFKYPITQCLAAPGVYRMVLQQKTSNLRFPTLEHCTTGGESLLPEEYEQWKQRTGLSIHEVYGQSETGISSATLREMKIKRGSIGKAILPFDLQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFMEYENSPESTSEVECGDFYNSGDRATIDEEGYIWFLGRGDDVINASGYRIGPVEVENALAEHPAVAESAVVSSPDKDRGEVVKAFIVLNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRKVEFVSELPKTVTGKIKRKELRNKEFGQL
What is the function of this protein?
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804, PubMed:12709059).  Capable of activating medium-chain fatty acids (e. g.  butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e. g.  benzoate (PubMed:11470804, PubMed:12709059).  Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity).  Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity).
What are the official names of this protein?
Acyl-coenzyme A synthetase ACSM1, mitochondrial, Acyl-CoA synthetase medium-chain family member 1, Benzoate--CoA ligase, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, Lipoate-activating enzyme, Middle-chain acyl-CoA synthetase 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion.
Protein: ACP_PHOPR
Sequence: MSNIEDRVRKIIIEQLGVDEAEVKNEASFVDDLGADSLDTVELVMALEEEFDTEIPDEAAEKITTVQAAIDYVNSASE
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_ALKCK
Sequence: MHKGLKRLGVITSLGVLLVLIQGALVTNTGSGEGCGQTWPLCFGQVIPLDPPPETVIEFSHRLVAGIVGMLVILMAIWSWRRLKHMPETRFLAVISVFMIIFQGLLGAGAVVFGQSDLIMALHFGFSALSFASVVLLTRLAFEDSNPQKQYAPIVSKAYKGYVIFVAIYSYVAIYTGAYVKHTNATLACSGFPLCNGQWVPDVFTEAIGVQLLHRSAAILLSLLLLVLFIWTVKTFRASRVLVVCASLAMLLVIGQAASGVAVVLTYNATLTLGIFHALLISLLFTLLCYMVMLVTRHKAK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARND_ECOSM
Sequence: MTKVGLRIDVDTFRGTREGVPRLLEILSKHNIQASIFFSVGPDNMGRHLWRLVKPQFLWKMLRSNAASLYGWDILLAGTAWPGKEIGHANADIIREAAKYHEVGLHAWDHHAWQAHSGNWDRQTMVDDIARGLRTLEEIIGQPITCSAAAGWRADQQVIEAKEGFHLRYNSDCRGVMPFRPLLDSGKPGTAQIPVTLPTWDEVIGRDVKAEDFNGWLLNRILRDKGTPVYTIHAEVEGCAYQHNFVDLLKRAAQEGVTFCPLSELLSGMLPLGQVVRGNIAGREGWLGCQQIAGSR
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: VP16_BPPRD
Sequence: MDKKKLLYWVGGGLVLILIWLWFRNRPAAQVASNWEGPPYMTYNQPQAGSVTLPVAGYTSPSPTLPNRNRSCGCNPAVSAAMAQGADLASKLTDSITSQLNDYASSLNDYLASQAGV
What is the function of this protein?
Protein of the infection vertex complex, which increases the vertex stability.  Anchors the vertex structure to the viral membrane.  Essential for viral infectivity.
What are the official names of this protein?
Protein P16, GpS, Protein S.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Note=Part of the capsid inner membrane.