PharMolix/UniProtQA huggingface dataset:
Protein: NCAP_I79A4
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDRKWMRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDTMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFDKSTVMAAFTGNTEGRTSDMRAEIIRMMEDAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: GLN15_ARATH
Sequence: MTSPLSDLLNLDLSDTKKIIAEYIWIGGSGMDIRSKARTLPGPVSNPTKLPKWNYDGSSTDQAAGDDSEVILYPQAIFKDPFRKGNNILVMCDAYRPAGDPIPTNNRHKAVKIFDHPNVKAEEPWFGIEQEYTLLKKDVKWPLGWPLGGFPGPQGPYYCAVGADKAFGRDIVDAHYKACLYSGLSIGGANGEVMPGQWEFQISPTVGIGAGDQLWVARYILERITEICGVIVSFDPKPIQGDWNGAAAHTNFSTKSMRKDGGLDLIKEAIKKLEVKHKQHIAAYGEGNERRLTGKHETADINTFSWGVADRGASVRVGRDTEKEGKGYFEDRRPSSNMDPYLVTSMIAETTIL
What are the official names of this protein?
Glutamine synthetase cytosolic isozyme 1-5, Glutamate--ammonia ligase GLN1;5, GLN1;5.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRA_MYCKA
Sequence: RPARSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNVPPAAMRYCVTGDALVRLPFGQSMRIADVVPGARPNSDNAVELKVLDRHGNPVAADRLFHSGDHQTYMVRTAEGYEVTGTANHPLLCLVDVGGVPTLLWKLIEEIHPDDYVALQRTPPMELGPADWHDTMEALLLGAFISEGCVSETRAGFANLDRDYFTMVARAYDAVVGDKRDVYQQTIASGSLQHTLYTQNVTALKQSRLWQILGMRSADTYVPEWMWHSPAAVKRVFLQALFEGDGSCSRRPHNTIQISYNTVSKQLAMDVQQMLLEFGVISRRYLHAAGEYKVVITDRAQAELFPKQIGFGGAKQTELSKILAAMPPCAGRDSDHVPGLARFIRRHCDSRWVDKEWLHKHNIDHLSRWRRDGAEILSHIADPDVRTIATDLTDGRFYYARVASVTDTGVQPVYSLRVDTDDHAFLTNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_STAA8
Sequence: MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SPRT_PSEPF
Sequence: MPEQLNTRVEDCFQLAESFFKRPFKRPVVSLKLRGQKAGVAHLHENLLRFNPQLYRENTEHFLKQTVAHEVAHLIAHQLFGDRIQPHGEEWQLIMRGVYELPPDRCHTYEVKRRSVTRYIYKCPCADSDFPFSAQRHSLVRQGRRYLCRRCRNTLVFSGEMRVE
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_CHLAB
Sequence: MAPKKTTKKGGPKKRPSAEKRIITSQKRCLINQSFKSKAKTMMKKFEAALKAGDQTSIASGLQLVYSVVDKAVKRGILKHNKAARIKSRATLRANAKI
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: U587_DICDI
Sequence: MVRQSISLKAELEEIQNIFPATYKIFFLKIKCSNCGEIPDKWIGLDKSNIEVIGKSNVNLATKCKGCNRENSIVIEDTDYSSRTIESEKDFEIARFDCRGVEIEEFDPRDNWIVVSSSGKEYKDVDLEEGEWSEFEERTSTSLTILSIESSIKKIK
What are the official names of this protein?
UPF0587 protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0587 family.
Protein: YMA6_CAEEL
Sequence: MKHKRMMLPHYVRVYVCVRTDGENEKAGQSEEYDDDDKEENKKRRRNNGRRGPPEKKKSRRGGEEQTQRII
What are the official names of this protein?
Uncharacterized protein F54F2.6.
Protein: MSRP_RALSO
Sequence: MLIKTDRWLRGDDIPASEITPQHLFDQRRRLLAAAALGAAGAALSPWAARRAFAASPAPAWLAAKPNPAYATVEKPTPFDEVTTYNNFYEFGTDKSDPARYAGTLRPHPWQVSVEGLVKAPKTYDLDDLMKMAPMEERIYRLRCVEGWSMVIPWVGFPLAELIRRVEPQGSARYIQFISLADKRQMPGVSSPVLDWPYSEGLRMDEAMHPLVLLTFGLYGQVLPNQNGAPVRVIVPWKYGFKSAKSIVRIRFVDKQPPTSWNIAAPNEYGFYSNVNPSVDHPRWSQATERRIGEDKGGFGGLFAPKRKTLMFNGYDQVASLYTGMDLRKFF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: RR3_PORPU
Sequence: MGQKIHPLGFRIGITQKHRSSWFASSKDYSVLLQEDHKIRSFIHGKLSNASIAKIEINRKADQVEVLIATARPGIVLGKSGAGIESLRNSLTLILDPNKQIRVNVVEISDPDSEATLVAEFITQQLEKRVAFRRAVRQAVQRAQRANTQGVKIQVSGRLNGAEIARSEWVREGRVPLQTLRADIDYCHRQAHTTYGVLGVKVWLFKGELLPDSKVVELAPSQDQINPDVS
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPF_PROMA
Sequence: MNDSLIFATEGFALNLNLFETNVINLAVVAFGLYKFLPNFLGGMLERRRSAILQDLKDAEDRLAKASESLKQAKLDLSSAEQKAGKIRTDCQARAEAIRLESEKRTVEEMARIKQGAASDLNVEAARVSGQLRREAAKLAIEKALSTLSGKLDDKAQDKFLKQSIKNIGDI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: XYLO_PRERU
Sequence: MHHARNVQFSNIHVSTVDEDVRPDFVEVDTKGWGDQGDGTYRNPXSDPDVIRVGNKXYMVASDFHXMGMQVLESDDMVXWRYISQIYRRFNEPGWDANLHYAGGSWAPSIRYHSGLFYVYFCTPDEGLYMSTASNPAGPWAPLHLVKRVAKWEDPCPFWDEDGQAYIGRSQHGAGPIIVHRMSADGKTLLDEGKTVYEGPIAEGTKFMKRNGWYYLIIPEGGVGTGWQTVLRARNIYGPYERRIVLEQGSTGVNGPHQGALVDAPDGSWWFYHFQETPVLGRVVHLQPARWEADWPVIGVDYDKNGIGEPVATWKKPVSSVGTAGFQTCDDSNDALGLHWQWNHNPVDTHWNLTDRKGWLTLKAMPADSLKMVRNMLTQKVVGYQSESTTKVSIKGDSYAGLFCSGKLFCGVGLCKDGVFIEFGGQRKIIDKGSYQEVWFKVTNDCEQNRHLFYYSIDGEHYQPAGSAFAMSGGYWKGIRVGCLTTFLQAKRLLRARHLRMLNSTISIKNSPNSLADC
What are the official names of this protein?
Putative beta-xylosidase, 1,4-beta-D-xylan xylohydrolase, Xylan 1,4-beta-xylosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
Protein: EF1B_METMJ
Sequence: MGNVAIIVKIMPESPEVDREALKAAVRAAVPVDDIQEEPIGFGLVALKAAVVVPDKAGAPDEVEAALQKIEGVASAEIVESTLV
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: RSMG_BIFLO
Sequence: MTDQLQGSPVLAEVLGDALPKLERFHAKIAEEGEPRGLIGPRDVDIIWERHILNSAAIVPYVRNATNGIRFKTVADVGSGGGFPGLVAAACLPDHDFTLIEPMERRIEWLHECVGLMQLQNVEIIRGRSDAVIQQVRKREIHPFAVVTCRAVAPMTKLSGWTLPLLKPSGQLIALKGRSAQAEIDKAGKEIAKFGGRRPRVVEAAVGPDLEPTHVVIVDKR
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_ALKOO
Sequence: MKKIMIDGEQLTLQDIIHVTRNFYEIELSEDAKNRVRNNRKVVDRYVEEEKVVYGITTGFGKFSDVVISKSETEALQRNLIISHACGVGNPLEEDVVRGIMLLRANALSKGYSGIRLETLSTLIEMLNKGVHPVIPEKGSLGASGDLAPLSHMVLVLIGEGEAIYQGKRMSGREAMEAAGIRPVVLTSKEGLALINGTQVMTAIGALTVYDAINLSKISDIAAALTIEAQRGIVTAFDKRVHEVRPHAGQISCAENLNRLLEGSTYTTKQGEIKVQDAYTLRCIPQIHGASKDAIQYVENKINIEINSATDNPLIFSEDNDVISGGNFHGQPMALSFDFLGIALAEIANVSERRIERLVNPQLSGLPAFLTEKGGLNSGFMITQYSAAALVSENKVLAHPASVDSIPSSANQEDHVSMGTIAARKAREIYKNAVNVVAIELMAAAQGIDFYEGYTLGEGTQIAYDTIRNKVSKLQEDRVMYFDINQCANLIFSGELIEAVEKAVELQ
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_RICFE
Sequence: MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHEEMINLLASSESETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEKPLDIVKRAIAEAKISAYGVVIYDTAGRTQIDKEMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTANSFNEKLEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTLKERENPDIINASRRKRIAAGAGTTVQKVNILLKQYKQISEMMKKASKMNPKNLLRNGIGKLFS
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.  Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle protein, Fifty-four homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: SYA_ACIFI
Sequence: MQAQAIRQAFLEYFVEQGHQIVPSSPLIPRNDPTLLFTNAGMVPFKDVFLGLETRPYRRAVSSQRCMRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKREVIGFAWRFLTERLGLPPEKLWITVYEEDDEAADIWMNEIGVDPARLSRCGEKDNFWSMGDTGPCGPCSEIFYDHGPHIPGGPPGSPEEDGDRYIEIWNLVFMQFDRDSSGTLTPLPKPSVDTGMGLERLAAVLQGVHNNYDTDLFKPLIAAAAAISGKTYGSDAATDISLRVLADHIRACSFLITDGVLPANEGRGYVLRRIIRRAVRHGRKLGMETVFFHQLVAPLVAEMGSAFPELTRAQREVERALEREETRFRETLERGLSLLEEAIADLAAGAAIPGEIIFRLADTFGFPVDLTADIARERDLIMDMEGYEAAMADERSPLPCRLGGSGEVKTERVYHDLAMRLPVTEFTGYSTCADEGKVVALIRDGEEVAFLEAGDMGVVILDRTPFYGESGGQAGDRGELQSNDALFAVTDTQKPMGHLHVHLGRVESGRLQIGDMVVASVDEVARRATAAHHSATHLLHAALRNILGSHVQQKGSLVNPERLRFDFSHPEPVTAAQLREIERVVNAAIRNNVGAETRILPVAEAQALGAMALFGEKYGDEVRVVRMGDFSMELCGGTHVEALGDIGVFKILSESGVAAGIRRIEAVTGAVALEAIQRDEERLQAAAGLLKVAPAELDQRLAQTLERLRQLEKELEKVKRDEAVRAGAGLAAEAEDVGGVPVLIRRLEGMDGKALRDALDRLRSQLPDGVIVLAGVEREKVALIAGVGKGLTGRVHAGELVNTVAQPLGGKGGGRPELAQAGAGNPAALDAALNAARDWVKGKLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_CHLT2
Sequence: MWTFPVDYDVIVIGAGHAGCEAAYCAAKMGASVLLLTSNLDTIAKLSCNPAVGGIGKGHIVREIDALGGIMAEITDLSGIQFRILNQTKGPAVRAPRAQVDKQLYHIHMKRLLEQVPGLHIMQGTAEALLDNGEKVLGVSTKEGWAYLGKTVVLSSGTFMRGLIHIGTQNFSGGRLGDAASLGLSEDLKRLGFPLGRLKTGTPARLLASSIDFSVMEEQPGDHNVCFVHRNEMFVPTLPQVSCHITHTTDQTKDLITKNLHRSALYGGRIEGVGPRYCPSIEDKIVKFADKDRHHIFIEPEGLNTQEVYVNGLSTSMPFDVQYDIIRSVSGLENAIITRPAYAIEYDYVHGNVIFPSLESKLIEGLFLCGQINGTTGYEEAAAQGLIAGVNAVNKVLRRPPFVPSRQESYIGVMLDDLTTQVLDEPYRMFTSRAEHRLLLRQDNAGMRLSHYGHSLGLLSSERYAMFQEQKACIEQEKERLSKTFRKYGDTVVPLTRVLCRPEVSYQQLLTEFPADVRDLGPIVGASLEMEIKYSGYISRQQTLIRSMERSENISIPEDIDYHSISALSLEAREKLSKFTPRTIGSAARISGISVADIQVLMVSLKKDAH
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCCP_CHLMU
Sequence: MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPIPSDQNLGNPIVKEVGEKKEDKPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVVCIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRIVKA
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxyl carrier protein of acetyl-CoA carboxylase, BCCP.
Protein: SOVO_SEPOF
Sequence: PKDSMLLLQVPVY
What is the function of this protein?
Has myotropic activity targeting the genital tract.
What are the official names of this protein?
SepOvotropin.
What are the subcellular locations of this protein?
Secreted.
Protein: IPRI_MOUSE
Sequence: MAMELFRVCLVVVTAIINHPLLFPRENATIPENEEEIIRKMQEHQEKLRLEQLRLEEEVSRLEAEKEALRQVEEEQQQLEAHTAWDLWTTLCMVLFLIIEVLRQNHQEGTFPECLGGDEDELSGLGGTLLQGLPLPNRATLDHFYEHCIRSTTGDATRTQEFVEGFVDDLLEALRSTYNGKTDMELEDFIGVGSMYENWQVERPLRCHLFIPFIPPEPYSFHPEFWCSSLSTPLERQGYGQIKVTLADGNPLGCVCGKAKLEEDMLCLLYGKNRGAWPSSAGCGEMEGLLCSRESSYLDVMQVMKWFQMALTRAWHRIAHKYEFDLAFGELDTPGSLKIKFRSGKSMPFILTPVIQCNDSDLYFILQLPKEPCGGGPASSAHWLLSFAVYEREFLRMTGKALPEGACHLSCLQIASFLLSKQTRLTGPSGLSDYHLKTALLHLLLSRQASDWKASKLDVRLQDLFCFLERSLLEKKLYHFFMGNHKVPEALGLPEVVRRAEPLNLFRPFVLQRTLYRNTVDSFYEMLKNAPALISEYSLHVPSVRASPPPKAVVS
What is the function of this protein?
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
What are the official names of this protein?
Inositol 1,4,5-trisphosphate receptor-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the ITPRIP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus outer membrane; Single-pass type I membrane protein.
Protein: KA124_TITST
Sequence: WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
What is the function of this protein?
Inhibits high conductance calcium-activated potassium channels.  Reversibly inhibits Shaker B potassium channels (By similarity).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 12.4, Butantoxin, BuTX, TstBut.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 12 subfamily.
Protein: AK2E4_BOMMO
Sequence: MAVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQVGQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIATKPDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTLTALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKNHRVIDISDWKDYPNYPN
What is the function of this protein?
NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity.  May play a role in the regulation of molting.  Has lower activity with phenylglyoxal and isatin (in vitro).  Has no activity with NADH as cosubstrate.  Has no activity with nitrobenzaldehyde and 3-hydroxybenzaldehyde.
What are the official names of this protein?
Aldo-keto reductase AKR2E4, 3-dehydroecdysone reductase, Aldo-keto reductase 2E.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HIS1_YARLI
Sequence: MDLVNNLNDRLLFAVPKKGRLYEKAVELLKGSDIQFHRHNRLDIALSTNLPLALVFLPAADIPRFVGEGRVALGITGIDQVREAKMDVENALDLNFGSCKLQVQVPEKGPYTDPKQLIGKSIVTSFTSLAEEYFAELEGVPVKDITTNIKFVGGSVEAACALGVADGIIDLVESGETMRAAGLKPIATVLETSASLIVSKNPSHPELVQMIKSRIEGVLAANKYVLCNYNAPRDKLDALLKITPGRRAATVSPLDDEGWCAVSSMAEKKKIAQIMDELKKEGASDILVFSISNCRV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGP2_DICDI
Sequence: MSSSANSSPATTKFKFTDNLWDGFDLLVKRTDNDLIQSKNILNFFKKKAELEEQHSKKLEKLSLKTMMTIDESTSINAISYNSSWKKIINSSMMESEQHTLLNTSILNKVIQPLQAMIKDMETKRKKILQEGIKLKQDMKEMVDELKKSQFKYDKAGKDLESSRMELREYREQLDHQQQQQPSDSDLNNISKIERRIQRCEQDFSNCDEEYREQIKATNDFQHLYNTEKLPKILNDFEHFVISHSHFSKSYFTNLVSVLIELPSAYQQNYEFVKKSVEMIDITNDVQEFIRKNLMKKQLAQPFQYEPYIEGKLTKKTISLTWNNKILSQFSRSSNNNTATANNTSSGNLNPYLNGGIGGTKKDEPILPTASFKVSLDELMNRQKDNHPTLEVPYVLQVLSTRIAQMKGHVTEGIFRVPGIISTIKETRLRIDKADFNLSNIDDVRTPAALLKQWLRDIPTALIPDSLYQQCIDTPTNAIAIVKTIPIINQRVLCYLINFLQIFTKFEFVAHSKMGTSNLAMVFAPCILRCTSTDANVMLNNVPNERLFVETLIKQIPPPLNTNEFLNLPISMSDAINDSEDIEELNDLDQLSNDDNNNSNTNTSNISIGSGSNSNIVVNYSNNSPNIESSTLPSQSVVTTIETLPPLNDDHNSGSGNESNSSSSNSTTTPTGSPTTASKPRGPRTQTLGWVRIKPAPKPSAEPTITLSSSIAAGTTTTTTTATGITTTTTTTAGPEKTIISPVIIKPAAATPTTTTPTTTPTTTTSPTTATIPAVSTSTIKTSSPDRTTPLTSSPPLASTKSTDELMKKLDQFTQETTPSIRIATTTTPTTITTPTTTATTTTITTDKTTPVTSSPPTASNISSEDLMKKLDQFINF
What is the function of this protein?
Rho GTPase-activating protein involved in the signal transduction pathway (By similarity).  Regulator of the contractile vacuole network as well as involved in driving vacuole emptying.
What are the official names of this protein?
GTPase activating protein homolog 2, GTPase activating factor for raC protein CC, Rho GTPase-activating protein gacCC.
What are the subcellular locations of this protein?
Cytoplasm. Contractile vacuole.
Protein: NU1C_SACOF
Sequence: MIIDRVEVETINSFSKLELLKEIYGLIWILPILALLLGITIEVLVIVWLEREISASIQQRIGPEYAGPLGLLQAIADGTKLLLKEDILPSRGEIPLFSIGPSIAVISILLSFLVIPLGYHFVLADLSIGVFLWIAISSIAPIGLLMAGYSSNNKYSFLGGLRAAAQSISYEIPLTFCVLAISLLSNSLSTVDIVEAQSKYGFFGWNLWRQPIGFLVFLISSLAECERLPFDLPEAEEELVAGYQTEYSGIKYGLFYLVSYLNLLVSSLFVTVLYLGGWNFSIPYISFFGFFQMNKIIGILEMVIGIFITLTKAYLFLFISITIRWTLPRMRMDQLLNLGWKFLLPISLGNLLLTTSFQLVSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MDR3_TRIRC
Sequence: MAPTEEANVTKPTGELRPDEKLNYEEDVKCSGSSSTTVGKTAYDTDDISQSQAAELQDLARQLSRASRQGGLDVENEPQQVINPFLDSESDPELNPDSKSFNVAKWLKTILQITSRDPERFPKRTAGVSFRNMNVHGYGTAADYQSDVGNLPLKAWSGIMSMLGLRKKVRIDILRDFEGLVKSGEMLVVLGRPGSGCSTLLRTLSGETHGLYLDEGNDIQYQGISWEQMHKNFRGEVIYQAETETHFPQMTVGDTLYFAARARAPANRLPGVSREQYAIHMRSMVMSMLSLSHTINTQVGNEYIRGVSGGERKRISIAETTLSGSPLQCWDNSTRGLDSANALEFVKSLRLSTKYSGTTAIVAIYQAGQAIYDIFDKAVVLYEGHQIYFGNAVRAKEYFIEMGFDCPSRQTTADFLTSVTSPSERRVRPGYESRVPQTPAEFAQRWKESEDRRILMQEIDEYNKTYPLHGEQLQKFQASRLAEKSRSTSKSSPYTLSYPMEIKLCMWRGFQRLKGDMSMTLTSIIGNIAMSLIIASVFYNQQETTDSFFSRGSLLFFAILMNAFASSLEILTLWHQRPIVEKHDKYALYHPSSEAISSILVDMPAKLAVAIVFNLIIYFMTNLRRTPGHFFIFFLFSFTTTLTMSNVFRSIAAVSRTLSQALVPTSIFMLALVIYTGFTIPVRDMRPWFKWISYINPIQYAFESLMINEFHDREFKCAVYIPSGPGYSNVSGTSKICAAKGAMAGKPTVSGDVFLRETYSYYASHMWRNYGIIVAFFLFFLFVYITATELVSAKPSKGEILVFPKGKVPAFLKQSKKKQDPEAASTQEKQPVETSGHDQTAAIVKQTSVFHWESVCYDIKIKKESRRILDNVDGWVKPGTLTALMGVSGAGKTTLLDVLANRVTMGVVTGEMLVDGRLRDDSFQRKTGYVQQQDLHLEISTVREALTFSALLRQPNTTPYEEKVAYVEEVIKMLGMEEYANAVVGVLGEGLNVEQRKRLTIGVEIAAKPDLLLFFDEPTSGLDSQTAWSICTLMRKLADHGQAVLCTIHQPSAMLMQEFDRLLFLASGGRTVYFGELGKHMSTLIEYFESKGAPKCPPDANPAEWMLEVIGAAPGSKTDIDWPAVWRDSAERVEVRRHLAELKSELSQKPQTPRLTGYGEFAMPLWKQYLIVQHRMFQQYWRSPDYIYSKACLAIVPTLFIGFTFYKEQVSLQGIQNQMFAIFMFMILFPNLVQQMMPYFVIQRSLYEVRERPSKTYSWIAFMISSVVVEIPWNALLTVPAFFCWYYPIGFYKNAIPTDAVTERSGTMFLLILIFLMFSSTFSSMVIAGIEQAETGGNIAQLCFSLTLVFCGVLVSPTAMPGFWIFMYRLSPFTYFVSAVLSTGVGRTDIVCAANEILRLTPAAGQTCMEYLGPYTKFAGGRILTPDATDMCEFCAVADTDTFLKGVNIIFDERWRNIGILFGYIAFNMVGAIGLYWLLRVPKRKSGVKQGQQPQKQANETKA
What is the function of this protein?
Pleiotropic ABC efflux transporter involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole.
What are the official names of this protein?
ABC multidrug transporter MDR3, Multidrug resistance protein 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.