PharMolix/UniProtQA huggingface dataset:
Protein: RSD_SALSV
Sequence: MLNQLENLTERVGGSNKLVDRWLDVRKHLLVAYYNLVGIKPGKESYMRLNEKALDNFCQSLVDYLSAGHFSIYERILHKLEGNGQLLHAAKIWPLLEDNTQRIMDYYDTSLETAIDHDNCLEFQQALSDIGEALEARFVLEDKLIMLVFDAMHDGARVKRPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSRP_SHEB5
Sequence: MAPKVFYISDGTAITAEVFGHAVLSQFPLEFESLTIPFVETLTKAEQVKRQINDCFITTGERPLVFHSIVKAEIRDIIYSSEGLDYDFLNTFVAPLEQHLGVSASPVLHRTHGKANHGYEARIDAINFAMDNDDGQTMKHMDQADLVLLGVSRCGKTPSSLYLSMQFGIKAANYPFTEDDMDNLKLPDALKRNKKKLFGLTIDPVRLHEIRQSRMENSRYSSLKQCRLEVKEVEMLFKRERIPYIDTTNHSVEEIATKILDVTGLERHMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: LSPA_BRUMB
Sequence: MKRHAVWSSLFVVILAVLIDQGIKYLVESRMFYGQQIDLLPFLALFRTHNEGIAFSMLAWLHDGGLIAITLAVIAFVLYLWWTNAPERVFARYGFALVIGGAIGNLIDRVMHGYVVDYVLFHLPTWSFAVFNLADAFITIGAGLIILEEFLGWRRERISH
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLDE_ACTSZ
Sequence: MAQYSAQFPHAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVKKHEERAGGAANVAMNIASLNVPVRLLGLTGDDEAGNALTGLLEKQKICCDFVKLSSHPTITKLRILSRHQQLLRLDFEENFNNVHSDNLLTKLESAVKNVGALILSDYGKGTLNDVQHMIRIARQAKVPVLIDPKGTDFERYRGATLLTPNMSEFEAVAGVCQSDEDIVEKGLKMIADYDLTALLITRSEKGMTLLRPNQPAFHLPTEAKEVYDVTGAGDTVISVLATALADGRTVEEACYLANVAAGIVVGKLGTSAVSTVELENAIHGRTVSGFGIMTENELKNAVKLAKERGEKIVMTNGCFDILHPGHVSYLENARKLGDRLIVAVNTDESVKRLKGETRPINDLASRMAVLAGLSSVDWLVAFDEDTPQRLIGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVSVLNFENGCSTSNVIKKIRDLKD
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: Y310_STRP2
Sequence: MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHAARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKFNELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMGKNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPIWNLPLHHPVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYASPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMNDLGITPADRKVAVVARQKAEETGGPALAFELPNGEIVTGKNSELFGPTAAALINAIKKSADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEELGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK
What are the official names of this protein?
UPF0371 protein SPD_0310.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: ILVD_SPHAL
Sequence: MPSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEVALDLVDAMVAAADEKYSDEEVLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVVEMCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMEDIDRLSRRVPCLSKVAPAKSDVHMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDALNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSLDLDRISGVIRSADHAFSKDGGLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVENGDLINIDIPSRTITLAVADSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAMTTSAARGAVRDLSQLKGKG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: MAP1_STAES
Sequence: MIVKTDEELQALKEIGYICAKVRDTMKEATKPGVTTRELDHIAKDLFEEHGAISAPIHDENFPGQTCISVNEEVAHGIPGKRVIREGDLVNIDVSALKNGYYADTGISFVVGKSDQPLKQKVCDVATMAFENAMKKVKPGTKLSNIGKAVHATARQNDLTVIKNLTGHGVGQSLHEAPNHVMNYFDPKDKTLLKEGQVIAVEPFISTHATFVTEGKNEWAFETKDKSYVAQIEHTVIVTKDGPLLTTKIDD
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: PSBL_SORBI
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CBIQ_SALTY
Sequence: MTGLDRLSYQSRWAHVAPQRKFLLWLAMMILAFVLPPVGQGIELLIIAGLSCWLLRISLWRWCRWMAIPFGFLLVGVITIIFSISREPQMLLAGISVGPYWIGITRAGVVTANETFWRSLTALSATLWLVMNLPFPQLISLLKRAHIPRLLTEQILLTWRFLFILLDEAVAIRRAQTLRFGYCSLPNGYRSLAMLAGLLFTRVLMRYQQMTTTLDIKLYQGDFHL
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.  The complex confers cobalt uptake upon expression in E. coli; can also transport nickel with a very low affinity.
What are the official names of this protein?
Cobalt transport protein CbiQ, Energy-coupling factor transporter transmembrane protein CbiQ, ECF transporter T component CbiQ.
What is the protein family that this protein belongs to?
Belongs to the CbiQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYP_CHLTE
Sequence: MADKITSRQEDYSQWYIDLVRSAKLADYSDVRGCMVIRPNGYAIWEKMQAALDGMFKQTGHVNAYFPMFIPESFIAKEAEHIEGFAPECAVVTHGGGEELAEKLYVRPTSETIIWSSYKKWIQSYRDLPILINQWANVVRWEMRTRLFLRTTEFLWQEGHTAHATPEEAQEEVIRMINIYRTFAEEYMAMPVIVGKKSESEKFAGADATYCIEAMMQDGKALQAGTSHNLGQNFAKAFDCQFQTKDGVLDYVWATSWGVSTRLIGALIMAHSDDKGLVLPPKLASRQVVIIPILKGNKDEVRARARFIAKTLNRHGIPTFVDDSENNSPGWKFAEYELQGIPVRIELGPRDLEQGKCIVARRDTFEKTELLLDDELTINIEEILNNIQQNLYDRALQFRLDNTVEATTWEEFKASVEKGFVIAHWDGTHETEALIKEETKATIRVIPTDEEYRQQYNMDEPGTCIRSGKPAAQKVVFAKAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAT2_HUMAN
Sequence: MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQGEATRKLAGK
What is the function of this protein?
Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur (PubMed:15283699).  May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine (PubMed:12803540).  However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo (PubMed:15283699).
What are the official names of this protein?
Thialysine N-epsilon-acetyltransferase, Diamine acetyltransferase 2, Spermidine/spermine N(1)-acetyltransferase 2, SSAT-2.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Intracellular organelles.
Protein: HLDD_BURO1
Sequence: MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFRNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDTCLAQGTQFLYASSAAIYGGSTRFVEERDVEAPLNVYGYSKFLFDQVIRRVLPSAKSQIAGFRYFNVYGPRETHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYAPGEQTRDFVSVEDVTKVNLFFFDHPEKSGIFNLGTGRAQPFNDIASTVVNTLRALDNQAPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: LPXA_PSEPF
Sequence: MSLIDPRAIIDPSAVLADGVEVGPWSIIGAGVEIGEGTVIGPHVILKGPTRIGKHNRIYQFSSVGEDTPDLKYKGEETRLVIGDHNVIREGVTIHRGTVQDRSETTLGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVDDWAILSGFTLVHQYCHIGAHSFSGMGTAIGKDVPAFVTVFGNPAEARSMNFEGMRRRGFSEDAIHALRRAYKTVYRQGLTVEQALAELAEPSAQFPEVAMFRDSIQSSTRGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NKX22_HUMAN
Sequence: MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
What is the function of this protein?
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).  May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance.  Binds to elements within the NEUROD1 promoter (By similarity).
What are the official names of this protein?
Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog B.
What is the protein family that this protein belongs to?
Belongs to the NK-2 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LUXS_HELPH
Sequence: MKTPKMNVESFNLDHTKVKAPYVRVADRKKGANGDVIVKYDVRFKQPNQDHMDMPSLHSLEHLVAEIIRNHASYVVDWSPMGCQTGFYLTVLNHDNYTEILEVLEKTMQDVLKAKEVPASNEKQCGWAANHTLEGAQNLARTFLDKRAEWSEVGV
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: CTNB_TRIGR
Sequence: MEQARYSNQQSVNPQQKGFGGPGLQDLPKQDPMQNTMEWQHHGYGMDSGFQSSATSHPPSVSSKSRHEDGGEEAQAQGMFEWDAGYGQAYTQEQVDEMNQQLTQTRSQRVRAAMFPETLEEGVQIPSTQFDPAHPTAVQRLSEPSQMLKHAVVNLINYQDDADLATRAIPELTKLLNDDDLVVVNQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAMSNSNDAETTRCAAGTLHNLSHHRAGLLQIFKSGGIPALIKLLSSPVESVLFYAITTLHNLLLHQEGSKMAVRLAGGLQKMVALLSRNNPKFLAITTDCLQILAYGNQESKLIILASGGPAALVHIMRTYDYEKLLWTTSRVLKVLSVCHNNKPAIVEAGGMSALGLHLGHHSNRLVQNCLWTLRNLSDCHRGTDDIEPLLQMLVQLLASNDINVVTCACGILSNLTCNNSRNKMIVSQMAGVEALVQTLMKAGDREEITEPAVCALRHVTSRHPGAEMGQNTVRLNYGIPVIVKLLHPPSRWPLIKATVGLIRNLALCSANHAPLREQGALHRLVQLLMRAHQDTQRRSSMGSTGSQGGNYADGVRMEDIVEGTTGALHILARDSHNRALIQGLNCIPLFVQLLYNNIENIQRVAAGVLSELSLEKQGAEMIEQEGATAPLTELLHSRNEGVATYAAAVLYRMSDDKPQDYKKRISVELGNSLFRGDSVPWGDPLDMPSDNQILPPSSMGGHPPDPGYPQPGSVHSLHSNHGEYRQPPPPMQGYHDGTGPIEPMMQDLDLGGGGDFGMDPGLPDMGPPASDLNLDSIPPADNTGLAFFDTDL
What is the function of this protein?
Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins.  The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.
What are the official names of this protein?
Catenin beta, Beta-catenin.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RS14_TROWT
Sequence: MSKLSKIVKNEKRKVIVARYAARRQELKRIIAAPGTAPERRDEAQAALQKLPRDASPVRVRSRDVVDGRPRGILSRFGVSRIRFREMAHRGELPGITKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: THII_THEAC
Sequence: MSLYMVRYSEIGLKGDRERSRMESILMDNIRKYYEIIGLRASCRIMSGHVLVEADGDGPLRHIMGIKSYSPVLRFRAETLEDITRIASEIYREKVRGKTFGVRCNRTGTHSFTSLDVERAIGDSLYDASAGVNLKNPDIWIHADIVGKDVFFYHEIIPGPGGLPLGSEGKYISLVSGGIDSPVSTWMIMKRGSPCDILFCSLSYPVDLRPFVDVVKKLVERWAPYRKPRIYVADCRSLIRTMVIEGRTKYSNVTFKRVIYRIAEKIALENGYNGIVTGESLGQVSSQTAENLKAIESGIGVPILRPLIGMDKDEVVDMARRIGTFPELSMGEFCSLFASRPIIRSKPEDIDEDMKQIDMEELFEGIRAYDIDDLSVALRTDLSLKGSIPKDAVIIDLRSRSQYEKDHIPNSINLPLGDAINVEDKGRTYVVYCGMGLQSAYVASMLRNRGITAYYSTFSDLKKRLSEKESGNITGIDQPAE
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_BRUA2
Sequence: MDRAEKREFVAWLNGAFKESGSVVVAHYTGLTVAQMSDLRSKMRDAGGSVKVAKNRLAKIALQGTESEGIADLFTGQTVVAYANDPITAPKVAVEFAKANDKLVILGGAMGATTLNADGVKSLASLPSLDELRAKLVGMIQTPAQRLAVLTSAPAGQIARVIGAHARKNEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: CRL_VIBVY
Sequence: MSEVTNNPTHNRLLAKLRAMGPYLRDPQSKEGLYYFDCLSVCIDDRKSPELREFWGWWMELEATEGGFTANYHIGKYDVEGNWLDLAIPKNALEEVNKTQNCFHLKLVKTLEENFQLSVAYHEQSVEFV
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes.  Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDAC1_HUMAN
Sequence: MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056).  Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666).  Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (PubMed:12837748, PubMed:16478997, PubMed:17996965, PubMed:19343227).  Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997).  Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374).  Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374).  Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227).  Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776).  Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965).  Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity).  Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity).  Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity).  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810).
What are the official names of this protein?
Histone deacetylase 1, HD1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL14_LEVBA
Sequence: MIQQESRLKVADNSGAREILTIKVLGGSKRRYAGIGDIIVATVKQATPGGVVKKGDVVKAVVVRTKSRVRRNDGSYISFDENAAVLIKDDKSPQGTRIFGPVARELRDNDYMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MT2_SHEEP
Sequence: MDPNCSCTAGESCTCAGSCKCKDCKCASCKKSCCSCCPVGCAKCAQGCVCKGASDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-2, MT-2, Metallothionein-II, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: HEM3_BURM9
Sequence: MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAASAQAQKGGA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CYC6_GLOC7
Sequence: MKKLVSSVILALILFGFSWVSPAFAGDAGNGSKVFSANCNACHLGGKNVVNAAKTLNKSDLEKYAMLDLEAIKTQVTNGKGAMPAFGKRLTPDQIEDVATYVLEKAEKGW
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid lumen.
Protein: CYB_VIVZI
Sequence: MTNIRKSHPLAKIINESFIDLPAPSNISAWWNFGSLLGVCLILQILTGLFLAMHYTADTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGMYYGSYTFSETWNIGILLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGVVSDSDKIPFHPYYTIKDILGLLLLILTLMLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAIIPLLHTSKQRSMMFRPLSQCLFWFLVADLLTLTWIGGQPVEHPFITIGQLASIFYFSILLILMPIFGTIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.