PharMolix/UniProtQA huggingface dataset:
Protein: CH60_NEIM0
Sequence: MAAKDVQFGNEVRQKMVNGVNILANAVRVTLGPKGRNVVVDRAFGGPHITKDGVTVAKEIELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGMKYVTAGMNPTDLKRGIDKAVAALVEELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINDAEKQIAALDNPFVLLFDKKISNIRDLLPVLEQVAKASRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLQDIAILTGGVVISEEVGLSLEKATLDDLGQAKRIEIGKENTTIIDGFGDAAQIEARVAEIRQQIETATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALLRARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNAGSGEYGDMIEMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEDKPAVPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AN36_HELPY
Sequence: MSNSMLDKNKAILTGGGALLLGLIVLFYLAYRPKAEVLQGFLEAREYSVSSKVPGRIEKVFVKKGDHIKKGDLVFSISSPELEAKLAQAEAGHKAAKALSDEVKRGSRDETINSARDVWQAAKSQATLAKETYKRVQDLYDNGVASLQKRDEAYAAYESTKYNESAAYQKYKMALGGASSESKIAAKAKESAALGQVNEVESYLKDVKATAPIDGEVSNVLLSGGELSPKGFPVVLMIDLKDSWLKISVPEKYLNEFKVGKEFEGYIPALKKSTKFRVKYLSVMGDFATWKATNNSNTYDMKSYEVEAIPLEELENFRVGMSVLVTIKP
What are the official names of this protein?
36 kDa antigen.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TYSY_LEGPA
Sequence: MKTYLQLLEHILQQGVEKSDRTGTGTLSVFGYQMRFDLTKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGHTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLTIKRKPASLFDYAYEDFEFLNYQSHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AM122_ALTAL
Sequence: MSKARSQDEVGWKRNESLCEYSMHRSRRPIQEKSIQSRAEHNFTLTRAYAINGSMTPDSSNLHHSSQVAVGRDAEGSANTLNTPFSEACFSQLISDGARSYLDFDFPDETIPGTSQAKNTEPDHQASGLQNQMSCDSLRNNTIMLDWLDLDYDGNLRQYSTAQLYGLLGADAHNGSAKCTLSLLPERMVADKAEAKLLLNHKMYGLTALCKNADRGSRRQQAVWEKVEVLLSSKHQTCVSDLLRKVDSSGEHQSLDLTSLPIEKLVQRAFRELGGLNLFIKEQDVTRIQERFLDPEKLPVDVSDMSLLITSLAWGALLDPEKLQRCYFARMVAFLCLAEKTGSDNLPALILGSISTAASLSLHLETALRKSCVSNDQAVQTKRAMWILYCIDKSYALRWQTFSLVGDGSLPTTNPPDTALPSEVATTLSLEWLRIRSQYSKICSNILQLGVGAEGEPSENRSNRAVVLSAALEEWYGSVEISQMMLSLEHSDAVHMKLQTSYHYYEARFQLLSISLPDPRSSSPTGSQECREVLRRSIREVITGSNTITSEYLLQDCNHLFIQTLALSMLALDILLESDQGCGKENRALLSIVAGFFARVDIILPQSSIFEEVSNLIEILTYR
What is the function of this protein?
Part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (By similarity).  AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III.  The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable).  AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization (PubMed:22846083).  The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin (PubMed:10875335).  The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol (PubMed:15066029).  The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet (PubMed:17990954).  Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures (PubMed:17990954).
What are the official names of this protein?
AM-toxin biosynthesis protein 12-2.
Protein: BIOD_BRUSI
Sequence: MNSRLIVTGTDTGIGKTVFSAALCHALGAAYWKPVQSGLEEETDSEIVARLAQASPQRILPEAWRLNTPASPHLSARLDGVEIRPEEMHIPATSLPLVIEGAGGLLVPLNDKTLFADLFAIWRIPAILCARAALGTINHTLLSLEAMRSRDIPVLGVAFIGEANEDTETTIAHLGRVKRLGRLPLLDDLSPEKLHHSFARNFHIDDFAGVAR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_PSEFS
Sequence: MSEPRKILVTSALPYANGSIHLGHMLEYIQTDMWVRFQKHRGNQCIYVCADDAHGSAIMLRAEKEGITPEQLIANVQAEHSADFAEFLVDFDNFHSTHSDENRELSSQIYLRLKEAGHIATRSITQYFDPEKKMFLADRFIKGTCPKCGTEDQYGDNCEKCGATYAPTDLKNPKSAISGATPVLKDSQHFFFKLPDFQQMLQTWTRSGTLQDAVANKIAEWLDAGLQQWDISRDAPYFGFEIPGEPGKYFYVWLDAPIGYMASFKNLCDRTPELDFDAFWAKDSTAELYHFIGKDIVNFHALFWPAMLEGSGYRKPTGIAVHGYLTVNGQKMSKSRGTFIKARTYLDHLSPEYLRYYYASKLGRGVDDLDLNLEDFVQKVNSDLVGKVVNIASRCAGFIHKGNAGVLVAENAAPELTDAFLAAAPSIADAYEARDFARAMREIMGLADRANAWIADKAPWSLNKQEGKQAEVQAICATGVNLFRQLVIFLKPVLPLLAADAEAFLNVAPLTWNDHATLLSNHQLNEFKPLMTRIDPVKVQAMTDASKEDLVASQTDTGESAPAGNGELAKDPISAEIEFDAFAAVDLRVALIVKAEAVEGADKLLRLTLDLGGEQRNVFSGIKSAYPDPSKLDGRLTMMIANLKPRKMKFGISEGMVMAAGPGGEEIYLLSPDSGAKPGQRIK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPF_STAAS
Sequence: MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
What is the function of this protein?
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
What are the official names of this protein?
Ribosome hibernation promotion factor, HPF.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REXO4_HUMAN
Sequence: MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSDDA
What are the official names of this protein?
RNA exonuclease 4, Exonuclease XPMC2, Prevents mitotic catastrophe 2 protein homolog, hPMC2.
What is the protein family that this protein belongs to?
Belongs to the REXO4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: H4_PISBR
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TBX2_CANLF
Sequence: MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPAPAREPPASPGSAPSPLRLHRTRADEKCAADSDPEPERLSEERAGPALGRSPGLDGGSPPRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDDGRKEAGEGKEPGLAPLVVQTDSASPLGAGHLPGLAFSGHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGGGGGGGGGPGTATGLDAGGLGPAASAASTPAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSHFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAEGSKAAGSNSREPSPLPELALRKVGAPSRGALSPSGSAKEAASELQSIQRLVSGLENQRALSPGRESPK
What is the function of this protein?
Transcription factor which acts as a transcriptional repressor (By similarity).  May also function as a transcriptional activator (By similarity).  Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes.  Required for cardiac atrioventricular canal formation (By similarity).  May cooperate with NKX2. 5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal.  May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity).  Plays a role in limb pattern formation.  Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (By similarity).  Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3.  Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling.  Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity).  Acts as a negative regulator of PML function in cellular senescence (By similarity).  Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity).  Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin.  Plays a role in induction of the epithelial-mesenchymal transition (EMT) (By similarity).  Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1.  Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity).  Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (By similarity).
What are the official names of this protein?
T-box transcription factor TBX2, T-box protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU1M_HIPDI
Sequence: MFMINLLLMIVPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFTKEPLRPLTSSISMFIIAPILALALALTMWTPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLLNGSFTLPTLITTQEHMWLIIPSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYANIIMMNIFTTILFLGAFHNPLMPELYTINFVTKSMLLTISFLWVRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVTMPIITAGVPPLT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TF29_ZYMTI
Sequence: MVFCTYCGQSFTRDEHLERHILTHTNVKPFKCFTCHMSFARRDLLQRHYTVHGRDQNQNEIPAVNGMIPKSAGRTPIACSNCAKTKTKCDKKFPCSRCAGRNLRCTLRPTRRASKNANRVGATLESATDVPTEVTTVNVEATSKDTRAQENSSSPSSQKSGTPISIGPIMEETPDIAPPQPFTEQVNGGPTPPEFSPDLQESFMDHNLMSGFPGLTNPSKDSSDDGSSPRFLLDWSQMQMPLGYDNMIQSDLMLDPELSFDPNSVPLAPHADGILSIMPELANGGMESLITPFETPKMSRSFVELGLGNSNPAFHSHRHQSMPSVQSIPNSGNEMPAMIAAQDGWSAFRCTPTLPSSSCPKTAKLNLEQLEETLRNHEGWVSWSPRWEDNDLAGGGDHLTVMQLHESTRDKLLAIMQSFLHKALETHREGRGTSNGSHSPNPSGASNFVLLPPGRVLEYFLRSYSNSFERYFPLTSRSTLDANELMHCYNDRAASILVLLMIAQGAANIPSPEARMLTGGLTEACRISLFDLIERNIIMSGDPIVLHSALLFTVQAAWSGDKWQMDIAMGQRGMYFAMLRHSGVLDRSSHAASAQPQRTLEQLWTDWIQNESRSRLIYSWVMVDQDLALFHDTAPLFSVTEFGAPMPDADRLWHAKSAEQWSSTFERVHEFSSGFSSVGSGARPLSLRDLFRHFLDDDLIPMGIEMTPLQLRLLLHPLQSMVCQFSQLLSCFAPATYRTSISVHPNQAQPSSRNISQSSTRTRLAEVQALLQRWFDLAERYLKANPLCALMQTNLILFHLISLNAVTNFPEIERLARRENVDGTYHQLLWLHKRCIPDVEEAVFHCGQIFRLVRSMPRGVRPPWWAGAIYRVALILWTDSLTHKDALTSTSPQGNGMFPSPIAGPSFAIDALPPDHALIVRYLTKREGVPCVTKLDGSQMGLERAYPVLRHCVEVIDEGCSTRFSDAIRGKLERLSRG
What is the function of this protein?
Transcription factor; part of the gene cluster 29 that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations.
What are the official names of this protein?
Transcription factor MYCGRDRAFT_87993, Conidial pigment biosynthesis cluster 29 protein MYCGRDRAFT_87993.
What are the subcellular locations of this protein?
Nucleus.
Protein: DLTC_BACC0
Sequence: MAEFKEQVLDILEEVCENDIVKENLDVQLFEEGILDSFAVVSLLVEFQERLDIEVSISDFDRDEWATPNMVIKKLEEIR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ECOL6
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CH61_MAIZE
Sequence: MYRAAASLASKARQAGNSLATRQVGSRLAWSRNYAAKDIKFGVEARALMLRGVEELADAVKVTMGPKGRNVVIEQSFGAPKVTKDGVTVAKSIEFKDRVKNVGASLVKQVANATNDTAGDGTTCATVLTKAIFTEGCKSVAAGMNAMDLRRGISMAVDAVVTNLKGMARMISTSEEIAQVGTISANGEREIGELIAKAMEKVGKEGVITIADGNTLYNELEVVEGMKLDRGYISPYFITNSKTQKCELEDPLILIHDKKVTNMHAVVKVLEMALKKQKPLLIVAEDVESEALGTLIINKLRAGIKVCAVKAPGFGENRKANLQDLAILTGGEVITEELGMNLENFEPHMLGTCKKVTVSKDDTVILDGAGDKKSIEERAEQIRSAIENSTSDYDKEKLQERLAKLSGGVAVLKIGGASEAEVGEKKDRVTDALNATKAAVEEGIVPGGGVALLYASKELDKLQTANFDQKIGVQIIQNALKTPVHTIASNAGVEGAVVVGKLLEQENTDLGYDAAKGEYVDMVKTGIIDPLKVIRTALVDAASVSSLMTTTESIIVEIPKEEAPAPAMGGGMGGMDY
What is the function of this protein?
Implicated in mitochondrial protein import and macromolecular assembly.  May facilitate the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
What are the official names of this protein?
Chaperonin CPN60-1, mitochondrial, HSP60-1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DPYL1_RAT
Sequence: MSHQGKKSIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTSADDFFQGTRAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTLTAKSHKSTVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSKVFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
What is the function of this protein?
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity).  Plays a role in axon guidance (By similarity).  During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (By similarity).  Involved in invasive growth and cell migration.  May participate in cytokinesis (By similarity).
What are the official names of this protein?
Dihydropyrimidinase-related protein 1, DRP-1, Collapsin response mediator protein 1, CRMP-1, Inactive dihydropyrimidinase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cell projection, growth cone. Cytoplasm, cytoskeleton. Perikaryon. Note=Associated with centrosomes and the mitotic spindle during metaphase (By similarity). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone. Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity).
Protein: SPZXB_ORYSJ
Sequence: MDATATDLRVSIAHQTRFAFRLAAALSSPRAHPAAGGAAGAGGSNVAFSPLSLHVALSLVAAGAGGATRDQLVSLLGVPGRGTAEGLHAFAEQVVQLVLADSSPAGGPRVAFADGVFIDSSLSLMKSFKDVAVGKYKAETHSVDFQTKAAEVASQVNSWVDRVTSGLIKEILPPGSVDHTTRLVLGNALYFKGAWTEKFDASKTKDGEFRLLDGKSVLAPFMSTSKKQYLSSYDSLKVLKLPYQKGRDLRQFSMYILLPEAQDGLWSLAAKLNSEPEFLEKRIPTRQVTVGKFKLPKFKISFGFEASDLLKILGLQLPFSSKADLTGMVGSPERHNLFVSSLFHKSFVQVDEEGTEAAAASAAVVSFRSAPVTVDFVADHPFLFLIREDMTGVVLFIGHVVNPLL
What is the function of this protein?
Probable serine protease inhibitor.
What are the official names of this protein?
Serpin-ZXB, OrysaZxb.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: RBFA_SHESA
Sequence: MAKEFSRTRRIAQQLQQELAVVLQRDMKDPRIGFVTVNDVDVSRDLSYAKVFVTFFEEDKELVQEKLNALITAAPYIRTLVAGRMKLRVMPEIRFVYDSSLVEGMRMSNLVSQVINSDKAKQQQFGSAEDVTSNDIDEADDTEGKA
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_SYNE7
Sequence: MDRQCAVASLTAFQFQIDRQCSQTRGRACSFHTPHGIVETPRFMPVGTLATVKTVTPAQLRDTGAQMVLSNTYHLHLQPGEEIVAKAGGLHRFMNWSGPMLTDSGGFQVFSLSELRKIEERGVTFRSPRDGAVIEFTPERSIRIQNALGADVIMAFDECPPYPAERKDVEAAVARTYRWLERCINAHERPQDQALFGIVQGGVYLDLRQQAARDLVQLDLPGYAIGGVSVGEPSEEIHRIVEATAPLLPAHKPRYLMGVGTYREMVQAIAAGIDLFDCVIPTRLARHGAALVKGDRWNLKNAQFREDFQPLDEDCNCYCCQNFSRAYLNHLIRSREILGYTLLSIHNITELVRFTTRIREAILSDRFVEEFGHWLQPSAVPVSP
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RS3_STRU0
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFIQKELAEASVSTIEIERAINKVIVSLHTAKPGMVIGKGGANVDALRAQLNKLTGKQVHINIIEIKSPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PSBX_GLOC7
Sequence: MTPSLANFLWSLVWGAVIVVIPATVALIFISVNDQIKRSQ
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.