PharMolix/UniProtQA huggingface dataset:
Protein: COX2_BUBDE
Sequence: MAYPMQLGFQDATSPIMEELLHFHDHTLMIVLLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLEMVPLKYFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SLMA_HAEI8
Sequence: MVEEQLSLSGVEEIAPKIETPKIEKRTVKERRQQVLTVLIHMLHSERGMERMTTARLAKEVGVSEAALYRYFPSKTKMFEALIEHIESTLLSRITASMRNETQTMNRIHDILQTILDFARKNPGLTRVLTGHALMFEEAQLQARVAQFFDRLEMQFVNILQMRKLREGRAFNVDERIIASHLVTLCEGQFMRYVRTNFRLNSSQSFEQQWRFIEPLFA
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CH10_ECO7I
Sequence: MNIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
Protein: PGDH_CAVPO
Sequence: MHVNGKVALVTGAAQGIGRAFAEGLLHKGAKVALVDWNLEAGVKCKAALDEEFEPQKTLFIQCDVADQEQLRDTFTKVVDYFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQHGGEGGVIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMARKLMNSGVRMNAICPGFVNTSILQSIEKEENMGPYIEYTGHIKDMMKCYGILDPEMIANGLITLIEDDDLNGAIMKITTSNGIHFQDYDTAPSYAKD
What is the function of this protein?
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites.  Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression.  Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation.  Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
What are the official names of this protein?
15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-PGDH, Eicosanoid/docosanoid dehydrogenase [NAD(+)], Prostaglandin dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_IDILO
Sequence: MMKDGLYDLFCESLESLALKPGQQLVAALGGGADSQTILDLLMRFRQQNPQYQYLAIHLDHSFHPSSADWSSTIEHAAKSYGVKTVFEPLNVPIENRQSKEAAGRESRYRRMAELTEDDAVLLLGQHRNDQIETFFLQLKRGSGPKGLSSMAAIQPWVGSRRLCRPLLSVSKEDILSYAQQQKLTWIEDDTNYDTRIERNFLRHKVVPLLEQRWPQFGNSVLRSAKLCAEQQQVMDELLQEKLYKAQKHKSHFPLSLLSEHSAAMQRALLRVWLQGQEYSLPSYEQLEQIRLQAQSATDDSQMQVQCDGYSVRYFQYALWCDNNTGQLPADCWLAEANVNLGEWGTLSVPDALLTNNNELRLTFSLTSEKLAKPGRQGRKKLKDWLKQAGIPPWLRARRPILELNGKYVWVAGLGWFSYQVIEKTEFDSLQLPEPDWVSSGADSYRQL
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSRP_SALPA
Sequence: MDNVVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYQQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPGNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLTLPTSLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPCLNSTNYSVEEIATKILDIMGLNRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: PSBA_HETTR
Sequence: MKNTFNTSNVFASAYSFWGSFIGFILSTSNRLYIGWFGILMFPLLVLATVAYIAAFIFAPPVDIDGIREPVAGALLYGNNIISGAVIPSSNAIGVHFYPVWEALGFDEWLYNGGTYQFVVLHFIFGAGAYMGREWEFSFRLGMRPWIFVAFSAPLVAASAVFIVYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHILGVAAVFGGSLFSAMHGSLVTSSLLAETAGDLSLNIGYNFGQEDETYSISAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVIGIWFTSLGVSTMAFNLNGLNFNQSIIDSSGHLINSWADIVNRADLGMEVMHERNAHNFPLDLA
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SC5A2_MOUSE
Sequence: MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA
What is the function of this protein?
Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1.  Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity).  Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (PubMed:20616166).
What are the official names of this protein?
Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: Y3024_HALLT
Sequence: MPYLGLLNKDEVLPPQVPAGTTVECPACGEGMSVVRSYNRGSTFVSRHFSHKGGGKGGGSGAGSNDGGCSGESEMHHKMKAIAYARLENDYPEATIELESNLEGRIPDVLLEFPEPCSPYGKGIAVEAQYQNKGKDKAAVVEHYLDREYSVAWLEEDAFSTHDVDLSGILSVWPYALPDRYETEGYPDVTRWLWQEKNPTVEMEIPIPADYWMSFDKSGEWVTIAEKSIKRRGSARISRTPDGHLTFSLGKAKGWGESESLSVQVVPNDVLKLRSFADDLERKAFGEDRPSPEECDPEWHELSKRWFKGSPTVTAWITAALPDPDGDSDVVVTLWKKQKETERVAMRVESYAAENLRDLADLLDRAFEIEKS
What are the official names of this protein?
Uncharacterized protein Hlac_3024.
Protein: GATC_BIFLO
Sequence: MPTFSREEIVHLGDLARIALTDEEITRLQGELNVIADSINKVQEVASDDVPPTANPVPLEAYLRPDVAETPLTQEEALAGGPKTEAGMFVAPRILGSEE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: TRMB_CROS8
Sequence: MNNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQQHALDHYWPVMGVEYRAEPLDLVALFGRDAPVTLEIGFGMGSSLVEMAKTNPQQNFLGIEVHSPGVGACLSAAHEEGVENLRVMCHDAVEVLEKMIPDGSLHMVQLFFPDPWHKARHNKRRIVQVPFAQLVLRKLQPGGVFHMATDWEPYAEHMLEVMSSVEGYENLSPTQDYVPRPASRPVTKFEQRGHRLGHGVWDLMFGRVK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MLRA_CHICK
Sequence: MAPKKAKKRIEGANSNVFSMFEQAQIQEFKEAFTIMDQNRDGFIDKADLRDTFAALGRLNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGLKSAYIKEMLMTQEGRFSQEEIDQMFAAFPPDVSGNLDYKNLVHVITHGEEKD
What are the official names of this protein?
Myosin regulatory light chain 2A, cardiac muscle isoform, G2, MLC-2A.
Protein: TAL2A_DROME
Sequence: MAAYLDPTGQY
What is the function of this protein?
One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259).  Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259).  Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956).  This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956).  Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956).  Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860).  Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753).  Essential for the development of taenidial folds in the trachea (PubMed:17486114).
What are the official names of this protein?
Peptide tarsal-less 2A, Peptide polished rice 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TSAC_HISS2
Sequence: MNITQIIEKLKQNEVVAYPTEAVFGLGCNPFSQSAVEKLLILKQRPREKGLILVAPKLDYFFSFIDKEQINSQHWQKLQQTYPRPITWIVPAKKDIAKFLCGNFNSIAIRVSQHPAIKILCEQTGFALTSTSANLSGIAPCKTSDEVRLQFGADFPVLDMSVGSATKPSEIRDLFTNQLVRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y101_SIRV1
Sequence: MEIDIKNECRKYIIQFRNWLESRYSDNIYFFNVFEDEEIILMQIKINMKKKEYEKAGMSMLKYLVRTFKYPNYIKVNWRYDKNMFKISAICGDINMSESNN
What are the official names of this protein?
Uncharacterized protein 101.
Protein: TPO_RANTE
Sequence: FLGALVNALRGLL
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Temporin-1To, Temporin-O.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
Protein: RL4_PARP8
Sequence: MELKLLNANGQEGAAVNASDVVFGRDYNEALIHQIVVAYQANARSGNRAQKDREQVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPEENFSHKVNKKMHRAGLCSIFSQLAREGRIAVVDELTLEAPKTKLLAEKFKAMGLDSVLVITDTVDENLYLASRNLAHVAVVEPRYADPLSLIYFKKVLITKAAVAQIEELLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HEM3_BRUA4
Sequence: MQTASLKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGGKGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLDLPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLGLGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAALDGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKAGPQFFEGWE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CE164_MOUSE
Sequence: MARRPILLGDQLVLEEDSDETYVPSEQEILDFARVIGIDPIKEPELMWLAREGIEAPLPKGWKPCQNITGDLYYFNFDTGQSIWDHPCDEHYRKLVIQERERWSAPGAIKKKDKKKKKEKKNKKDKETSKSPLVLGSPLALVQAPLWGLAPLRGLGDAPPSALRGSQSVSLGSSADSGHLGEPTLPPQGLKAAACAKGLLASVHEGKNALSLLTLGEETNEEDEEESDNQSVRSSSELLKNLHLDLGALGGNFEYEESPRTSQPDKKDVSLDSDADRPPTPGKLFSQGADSSVASANGSKSQGRGASPWNPQKENENSDPKASSSQMAPELDPGGDQPSRASKKQQAEDPVQAGKEGECRRESAAKEPKEASALENTSDVSEESEIHGHLKDARHSGSEASGPKSFLGLDLGFRSRISEHLLDGDTLSPVLGGGHWEAQGLDQEEQDDSKSSIAEPQSKHTQGSEREHLQSSLHSQATEEGPLQTLEGQPEWKEAEGPGKDSVASPAPLSLLQREQVLSPPASPERAEEKHSQAEELGLEQPEAEETEEKVAVCPSSPVSPEVQTAEPAAPQKLFSEAILKGMELEEDQRLLLEFQKEKPQQLEERLWEEEEEEVCQLYQQKEKSLSLLKAQLQKATAEEKEKEEETKIREEESRRLVCLRAQVQSRTEAFENQIRTEQQAALQRLREEAETLQKAERASLEQKSRRALEQLREQLEAEERSAQAALRAEKEAEKEAALLQLREQLEGERKEAVAGLEKKHSAELEQLCSSLEAKHQEVISSLQKKIEGAQQKEEAQLQESLGWAEQRAHQKVHQVTEYEQELSSLLRDKRQEVEREHERKMDKMKEEHWQEMADARERYEAEERKQRADLLGHLTGELERLRRAHERELESMRQEQDQQLEDLRRRHRDHERKLQDLEVELSSRTKDVKARLAQLNVQEENIRKEKQLLLDAQRQAALEREEATATHQHLEEAKKEHTHLLETKQQLRRTIDDLRVRRVELESQVDLLQAQSQRLQKHLSSLEAEVQRKQDVLKEMAAEMNASPHPEPGLHIEDLRKSLDTNKNQEVSSSLSLSKEEIDLSMESVRQFLSAEGVAVRNAKEFLVRQTRSMRRRQTALKAAQQHWRHELASAQEVDEDLPGTEVLGNMRKNLNEETRHLDEMKSAMRKGHDLLKKKEEKLIQLESSLQEEVSDEDTLKGSSIKKVTFDLSDMDDLSSESLESSPVLHITPTPTSADPNKIHYLSSSLQRISSELNGVLNVLGSLNSQPPPQGLGSQPPPPLFTSSLRSSKNVLDPAYSSQAKLSSLSSITPMSTQWAWDPGQGTKLTSSSSSQTVDDFLLEKWRKYFPSGIPLLSGSPPPPENKLGYVSVSEQLHFLQRSHPRVPRTDGVSIQSLIDSNRKWLEHFRNDPKVQLFSSAPKATTTSNLSNLLQLGLDENNRLNVFHY
What is the function of this protein?
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells.  Plays a critical role in G2/M checkpoint and nuclear divisions.  A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1.  Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity).
What are the official names of this protein?
Centrosomal protein of 164 kDa, Cep164.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis (By similarity). In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 (By similarity).
Protein: SSUD_CUPNH
Sequence: MQVFWFIPTHGDSRYLGTSEGAREVSFDYLKQVAVAADTLGYEGVLIPTGRSCEDPWVAASALAAVTQRLKFLVAVRPGLMAPTLAARMAATFDRISNGRLLINLVTGGDTAELEGDGLFLDHTARYEASAEFLRIWRQVLAASHDGDKVDYEGKHLSVKGATVLYPPLQQPHPPVYFGGSSAPAHALAGEQVDTYLTWGEPPADVAQKLDDVRRQAARHGRTVKFGIRLHVIVRETEAAAWAAADDLISRLDDETVARAQAVFAKMDSEGQRRMAALHAGGARRTREALEISPNLWAGVGLVRGGAGTALVGDPHTVAERMREYAELGIDTFVLSGYPHLEEAYRFAELVFPLLPRSVRDKLPGKVLSGPFGEVMATGIVPRAAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: CREL1_CAEEL
Sequence: MSRILLLLAVLIGATSQKEVTIKNEKCRTCNFLVSTFDEGLKKTARHHFAGGDTAWEEKNLGKYKTSETRLIEVLEGVCKKSSLPNMDNFMGIAEIEFKCSTQLEKHEETIEEFYYNQQHNNMSNWLCVEQLKLCCPDGHFGKNCEQCPGLSEKADVCFGKGSCHGDGSREGSGKCKCETGYTGNLCRYCDIEYFEESRTVQGVVCKKCHEGCLGVCSSESSKGCSKCKNGWKLTEEGCADVNECQNESACTKEHEICVNTVGSFKCECKEGYKKDDEQNCQFDVEASPDRPFMPIDQQLKLIAFSSLIIIITFVVWHGSPVLYVLTGITIVALILVDLYVNPDTIPDEAKRFLGY
What is the function of this protein?
Promotes L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.
What are the official names of this protein?
Protein disulfide isomerase crld-1, Cysteine-rich with EGF-like domain protein crld-1.
What is the protein family that this protein belongs to?
Belongs to the CRELD family.
What are the subcellular locations of this protein?
[Isoform a]: Endoplasmic reticulum membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform b]: Endoplasmic reticulum lumen. Note=Ends with a KDEL sequence, which is an endoplasmic reticulum retention signal.
Protein: LSRC_ECOLC
Sequence: MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVTTLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLFGVSAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrC, AI-2 import system permease protein LsrC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ANM3_ORYSI
Sequence: MATREHELRPEQERLGEDREEYEDGEEEEEEEEEEEGWDDWESDGDDAGGGGGGLLCLFCSARFDSESSLFSHCASEHRFDFYRVVKETGMDFYGCIKLINFVRSKVAENKCWSCGQVFSSNSELCGHLHALEIPQLEGKVPWGDDVYLKPFLEDDSLLHSLSVFDDDDEDDCGMPMEKGGCSAGNGSLAETCESNLKSIINDGSDVIDRFERTCTIESTDGECSGSLAQEPSDKQLKIARASAAARGINSVDESYFGSYSSFGIHREMLGDKVRTEAYRDALLGNPSLMNGATVLDVGCGTGILSLFAAKAGASRVIAVDGSAKMVSVATEVTKSNGFLYDENMEMQQKRDTQVITVVHTKAEELNHKIQVPSNKFDVLVSEWMGYCLLYESMLSSVLYARDHFLKPGGAILPDTATIFGAGFGKGGTSLPFWENVYGFDMSCIGKEVTGNSARFPVVDILASEDIVTETAVLNSFDLATMKENEMDFTSSFELRLSESGVSPSGVTWCYGIILWFDTGFTNRFCKEKPVNLSTSPFSTPTHWSQTIFTFEEPIAMAKEESAVVSSASVGTDECPAVMIRSRISIVRASEHRSIDISIETTGISSDGRKRSWPVQIFNL
What is the function of this protein?
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
What are the official names of this protein?
Probable protein arginine N-methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PERNA
Sequence: MTNLRKTHPLMKIINDAFIDLPAPSNISAWWNFGSLLGVCLVIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLFKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIVTAMVIVHLLFLHETGSNNPSGLNPDADKIPFHPYYTIKDALGLLLMILMLLLLAMFSPDPLGDPDNFSPANPLNTPPHIKPEWYSLFAYAILRSIPNKLGGVLALLASILVLLVIPLLHTANQRSMMFRPISQTLFWLLVADLIMLTWIGGQPVEQPFIIIGQVASILYFLIIIALMPLAGLLENYMLKWES
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.