PharMolix/UniProtQA huggingface dataset:
Protein: FRSA_YERPB
Sequence: MAQANLSEILFKPKFKHPETSTLVRRTHCNHVVNIHSALDGDTANHWYRMINRLMWTWRGIDPLEIEEVLSRIACSKAEHSNNELLDTVVGYRNGNWIYEWANQGMMWQQKAMEETDPGSAGQFWLNAANLYSIASYPHLKGDELSEQAEVLSNRAYEEAAKYLPYTLKELTFPISDGGSLSGFLHMPTVGSAPFPTVLMCGGLDTLQSDYHRLFRDYLEPKGIAMLTIDLPSVGASSRWKLTQDTSYLHQQVLQALADVPWVDHQRVSVFGFRFGANVAVRLGYLEPQRVRAVACLGPIVHHLLCNSDSLRKVPDMYMDVMASRLGMADSTDETLNTEMNRYSLKTQGLLGRRCQTPMLAGFWENDPFSPKEEAKLICSSSADGKLLAIPSKPLYENFHRALLQTSEWLEDKMR
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: HEMH_DECAR
Sequence: MPRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLILNGIILNIRPKKSAAKYASVWMPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGSPSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAANWLTKIRNQPEMRFVRNFHDHEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAERLNLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIAQEGRDDFLKAGGKEYHYIPALNEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREAFKFGARA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EDL2_ARATH
Sequence: MIIAKQYRCIHSATCHCTKGHLSEEVLFLMVQHLNWNPNVIATLSCVCKWFDDLAKRLLWKEFCRARAPKMMSDLQSSGSHSVDGSWRALGKLLIYCSGSSKGGLFNDVQISGHFVHRTRFSRTSGRSFLPPQCRTDDILYVSDPCEHLDQGEDGDLGFFRGIFKSFSMSKVRKLLIKKGTPFHPTEVCPYCKAKLWSMLQAKMIPQSASCRLGAYEDSIEYYVCLNGHMLGVCTLLPLSDSEGASEFQ
What are the official names of this protein?
EID1-like F-box protein 2.
Protein: 3L2H_PSEAU
Sequence: MKTLLLTLVVVTIMCLDLGYTLTCYKGRDRSSETCRSEQELCCTKTWCDQWCQDRGPRLEMGCTATCPRRMPGLDFTCCTTDNCNPVPT
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin homolog Pa ID, LNTX-ID.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_SHEDO
Sequence: MKASELREKSVEELNTELLGLLREQFNLRMQHATGQLTQTNQLKLVRRNIARVKTIITSKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: CQ10B_XENLA
Sequence: MAATCCWGRSGLSSLTRALLEAEKRQCRALVRTGKKPQGIRYLSSCGILASRCPKLPRPASPAHIQGRTFLNLAAPLLGSKRIEYSESKVLGFSIEQMYDIVADVQNYKIFVPWCNRSKVLSCKKGVTRAELEVGFPPVVERYVSEISVIPLHQVRAVCCDGKLFNHLETVWRFSPGLSGRPDTCTLDFCVSFEFKSLLHSHLASVFFDEVVKQMVCAFEKQAGRIYGRQEVPLAAAAKLRAMR
What is the function of this protein?
Required for the function of coenzyme Q in the respiratory chain.  May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
What are the official names of this protein?
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ZGPAT_DROPS
Sequence: MDEYEAQLVAVEQALENTTDEQQREELSTLRTNLQELLALTRETEADQTAQQGDILDDELLRLKSELNELEEAAANVGATKNKDEEQQLKDLRAKYNALVGEKCSAPHEHSWGASSYHNALICGVDDEVIINRNSELDVRLRVLYINPTHCEMLPCNYYLEGECRFDEIRCRYSHGALVPGASIKSYIPPDFPRLARNCPVLAKMPDRLWHRGRVLCANFVEQTCRVRLDGQDHKERERDFQFEELFPLITEKEDELTSEDSSSSPHDESSDEIDSDMDDLEAAHRSRMVELSLFTFKPTEKLGAWEQYTRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDACMELREAANGDQDYFSVERKLKREQRRQNKANEKAYARETQRTDVFSFLNGSVLGGGESRHQGDQAAKKAKTNDLQQHSTKTLNVETVRVADDIRRKQRDIAKVKQSLDRNATDIQLQKRLHMQLQSQKQELATLQAHEHRLSKEQHTRKNKMFEF
What is the function of this protein?
Transcription repressor.
What are the official names of this protein?
Zinc finger CCCH-type with G patch domain-containing protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURD_BUCA5
Sequence: MSYNYFGKKILILGMGLTGISCINFFLKKGIKPKIIDESKHPSNFIKIPQNIEYSLGSLDHQWILESDLIVISPGISSFKPILIKARLLGIEIISDIELFSREVTCPIISITGTNGKSTVATMIEKIAKKSGYKAFLGGNIGVPVLEILDKEADLYIIELSSFQLENTFNLKSKIAVILNISEDHINRYPNGFQQYKNTKLSVYNQAEICIINSNDKIEKSLIHSKNKKWISFGTNRSDYRICSKSNDPILFFKNKKILNTSEILLYGYHNYNNILVSLAISDAMQFPRNDAINVLKSFSNLPHRFQIIKNEKGVRWINDSKSTNVNSTQVALNSIKTTGTIRLLLGGDSKSANFNILKNIFRTLKIKIYCFGRDGIKLSKICEKKSIYVENLKKAVILISKQVKSGDTVLLSPGCSSLDQFSNFEERGNLFIKLIKEIT
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF75_HHV8P
Sequence: MAYDVTGLWLESDLTADEEAFVSFYTSRTGTLTLVPGGTGGYYLLWITFRRPPTSREERERRDVEIQTVLAVLSPLLGYPHVIRRSPPRGSERVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEPHPPQFIRAFTQNTDLVPYEGLEVPEGPQPVARPHIEDDVIMQAVMISLGADLLPLAVQASTGDNYNVARYFVIPGRCTMERWPWNCARQAFGIHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPALGPRAHSRFRRIFAKGVQQAEMLQGAGVPTLGGFLKTVRTIATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETLKLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVFAVVAESGAVPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPWLALSDGVRVSGHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLVLHSSMLAERVAPRVPDTVEAITPSMANLLHKDFETWVKALPQELLPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLQDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTLSERHVRITQQQETVEVLPFNSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQGNNVTILQNETVVFQETLTSLQVSWTSFSDEMWNLVTPPLHPLEDMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSPRRVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTLTEFLNRPDTFSICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQRWAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLRGTVLPSWAQGEYLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLMFHPWQWQHVPPDLTPLSMSPWAMAFQSIYLWSVKKINDHH
What are the official names of this protein?
Protein ORF75.
What are the subcellular locations of this protein?
Virion tegument.
Protein: MBL_CAEBR
Sequence: MFDENSNAAGTTPVASSLAATPNANLMSQVFNVKDSRWLQVEVCREFLRGQCARSDQECKFAHPPPNVDVQQGRVTACYDSIKGRCTRENPKCKYLHPPQHIKDQLLINGRNHLALKNLLSAQINQGGNQMINPMLALQQQAAAVNLLPNTQMYPQYYNGMMYQQVLPDPYAAAAQQLQTAALLGNVGGLLSAQSAAAALVANSSTQPPTPSPLLRLQRKRALEEDTSNGNDRTAAAHTQLLSLAAGAVPVKRPALDKNGAMLFSPAAPQTPQFNPYLLQTLQGYVPTVSCEYMQPPPF
What is the function of this protein?
Binds to RNA with repeat sequences CUG and CCUG.
What are the official names of this protein?
Muscleblind-like protein.
What is the protein family that this protein belongs to?
Belongs to the muscleblind family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PP13_HUMAN
Sequence: MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSFVKMVQVSRDISLTSVCVCN
What is the function of this protein?
Binds beta-galactoside and lactose.  Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882).  Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868).
What are the official names of this protein?
Galactoside-binding soluble lectin 13, Galectin-13, Gal-13, Placental tissue protein 13, PP13, Placental protein 13.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus matrix.
Protein: F16PA_PSYWF
Sequence: MTSLTQYFEQHPKLPQTQAVIDVITTITNVGKQITDLLRQGALADIHGEAGAENVQGEQQKKLDVIANDLLLEALTANKHCAGVASEELDDATPANESGELLVLFDPLDGSSNIDINMPTGTIFSILPHNNKGQAAQNADFLQKGTEQLAAGYLLYGSSAMLAFTLSESLDANNEGVVMFSLNPSTGEFELVKNNITIDADTKEYAINASNARHWLPPMQQYINELLAGSSGPRGKNFNTRWVAAMVGDVHRILCRGGIFIYPKDTKDPNKAGKLRLMYEANPMSLLIERAGGASTDALNRIMDCEPTDIHQRVAVVLGAKNEVEYVQKLHQQA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_IIV6
Sequence: MENNIENFDPSLVYFGDRGQDFKKMIRSILSLGMSDEYIPYLTTPESLNTYNTAFTSRGADDKNNYEMFEQLGDVSVNKFIVNYMYKRFPQLRNPNGVDVVAKLKIKYASKNQLQMLSESLDMWRFITATYDERTNKKKPLLEDTFESFFGATEWLIDSFIEDIALKQGNNNTYVGVGYNIINGILTTLFDRINISLKYENLVDAKTRFNEVIAEQKSIIGDVKYEDEYKNGKHTSKIYRYPPNSNLKELLGIGTGTLKRDAQEQAASRALETLALKHNIIKEAPDRFKAFM
What is the function of this protein?
Digests double-stranded RNA.
What are the official names of this protein?
Putative ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 142R family.
Protein: PHS_RHOP5
Sequence: MVERLSEAARRAALDALPDWSELPDREAITRTLKFKDFGQAFGFMAQVALVAEKHDHHPEWRNVYNTVEVTLTTHDAGGVTARDVDLARAIDAIAAPLSPR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RRF_XANP2
Sequence: MTTGTFDMSDLKRRMQGAVGVLRDELGGLRTGRASASLLDPITIEAYGARMPLNQVATVSVPEARLLSVQVWDRGMVSAVEKAIRDSNLGLNPNTEGQVLRLRIPELNQERRQELVKVAHKYAEAAKVAVRHVRRDGMDHLKKVEKDGEMSSDDLDRLSKDVQKATDETIAEIDQTLAQKEKEILSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL2_MACMU
Sequence: MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRDTKDLISNINVIVLELKGSETTLMCEYADETATIVEFLNRWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAC_CITK8
Sequence: MNNNLPTDAIAAAVAVLHKECVIAYPTEAVFGVGCDPDSETAVNRLLELKQRPVEKGLILIAANFEQLKPYIDDSMLTDTQREAIFACWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVSLCQAYGKPLVSTSANLTGLPPCRTVEEVRAQFGADFPVVEGETGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_GLUDA
Sequence: MSDIVLHEDIPESLLPGGEAAAAATHTVEIDSHALNFGPQHPSAHGVLRLVLEMEGEVVARAIPHIGLLHRGTEKLIEYKTYPKALPYFDRLDYVSPMCEEQAFALATEKLLGIDIPDRAKWIRVMFAEITRILNHILNLTALGLDCGAVTPALWGYEEREKLIEFYEAASGARFHANYFRPGGVSRDLPAGLEDRIAEWARQFPAWIDDLESLLTNNRIWKQRTVGIGIFTTEQALAWGFSGPCLRASGVPWDLRRAQPYDNYDKVEFNIPVARQGDCYDRYLIRVAEMRESVRIVEQCLAQMKPGPIKIQDHKITPPPRREMKRSMEALIHHFKLFTEGYHVPPGATYTAVESPKGEFGVYLVADGSNRPYRCKIRPTGFAHLQAIDEMSRRHMLADAVAIIGSLDLVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CLF1_KLULA
Sequence: MGDNSLSNEAITADNILKDAFSQKKQIAATTKADILDLEELKDWQRRKRTEYETVLKRNRLDLRQWMRYAQFEFDQKDIRRARSIYERALLVDHGFIPLWIQYIDSEIKWKNINHARNLLDRATNALPRVDKLWFKYLLLEESLGNQGIVRGIYTRWCSFEPGPDAWDSFIEFETRCLNFENVRNIYSKFVLVHPQIDTWLKWVRFEQTHGDISSVRTVFSFALDTLTSFSGTPLVDIERVIGSFASWEASQGEYERSRTLYRLAVERWPISEALKEQQIQFEKKFGSSKNMEDIVIAKRKAEYEQYLKSDPYHYSTWWVYIDLVEEKYQEQLTSAFQSFIELAKPKSLVKDSSWKRYIRICVRYLVYLELTINDLPTIRSVYQDILDIIPHKKFTFGKLWIMYAEFEIRQNNLLKARKILGVSLGKSPKPKVFKYYINLEIRLKEFDRVRKLYEKYIDFNPSSVQSWLDYAELEENLGDEDRSRGIYDISMSNNVGLSESDQLIVIQRYIAFETDAAEYEKARELYEKYLILSRYDVNIWINQALFESTIPTETQLIAYQQSHQDGNFDDDGEEEFSFEITPENKHHTRAIFEKAISYFKEHNEDKKRQQVLQSLLEYEKVHGNQETLEKVNARQPSLVREKVTIDNIEQESYKLDFPDDRVAQPPIARNLLALAKQWEKNSS
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle progression.  Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CLF1.
What is the protein family that this protein belongs to?
Belongs to the crooked-neck family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EIF3L_CAEEL
Sequence: MSRRVEFDLSTEDHSDRRRTNTFSSSADEDGVPNEVADYLVYFSRMVDEQNVPEILTLYDQAFPDLTERFFRDRMWPDENVVERIIGPGNKLFIILYKELYYRQLYARNTRGPLLVHRYESFMNYQELFSELLSSKDPIPLSLPNVWLWDIIDEFVYQFQAFCLYKANPGKRNADEVEDLINIEENQNAWNIYPVLNILYSLLSKSQIVEQLKALKEKRNPDSVADEFGQSDLYFKLGYFALIGLLRTHVLLGDYHQALKTVQYVDIDPKGIYNTVPTCLVTLHYFVGFSHLMMRNYGEATKMFVNCLLYIQRTKSVQNQQPSKKNFQYDVIGKTWDQLFHLLAICLAIQPQRIDESIASQLSERCGERMMHMANGNIDEFRNAFATGCPKFLSPTTVVYEGVNQSKEPLLRQTQSFLEGIESQMALPVLRGYLKLYTTLPTKKLASFMDVDDEHYDSFIGKLLTYKMIVNELGKEAGPSSADDDEPQTDIDFYVDRDMINIADTKVARHVGEHFIRHIQKLQEVQDVLKRLDIQKP
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_LEPIC
Sequence: MESPCRTITLEKNGTSLEPVHYSVQGKEILQIFKENFQKEDPVLFLDGTAGEGGHSFLFLKEFPNSRIILCDRDPIMLSRALTRLSDFSERVVSIQTNFSEINQKLLTSYGIDQTPQGILLDLGISTFHLFHSGRGFSFRESEPLDMRLNPNSGQSAEEILNIYPKDRLMNIFYTYGEERWSKKIAEVIVETRKQNSISTTFELANLVSKIIPRKFWPPGRHPATRIFQALRIEVNQELAHIENGLKLLLDLLRLGGVIQVISFHSLEDRIVKNSFRDYAKQNGFELLTKKPILPSQEEIDENPASRSAKLRILRKTKSVDKKYRNKNFEEEEE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_PARD8
Sequence: MSWFEALILGIVQGLTEYLPVSSSGHLAIGSALFGIEGEENLAFTIVVHVATVFSTLVVLWKEIDWIFRGLFKFQMNAETKYVINILISMIPIGIVGVFFKDTVEQIFGSGLLVVGCMLLLTAALLAFSYYAKPRQKESISMKDAFIIGLAQACAVMPGLSRSGSTIATGLLLGNNKAKLAQFSFLMVIPPILGEALLDVMKMVKGEDVAGDIPALSLAVGFMAAFVSGCVACKWMINIVKKGKLIYFAIYCAIAGLVTIACTLLK
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPR_SALPA
Sequence: MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLEQILLKSA
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1371_ENTFA
Sequence: MELIGHGHSCIEIRLNDGTNLLFDPFINGNPLADVSLADLHPDYILITHGHSDHIGDMLAIAQANKATIIAIAEVAMYAQSQGVKAHGMNLGGRYVFPFGSVKFVPALHSSGYEIDGVMTYMGEASGIILEAEDKKIYHAGDTALFSDMRLFAKDKSIDVAFLPIGDNYTMGPEDALEAIAYLNPEITIPIHYNTFPVIQQNPAIFVEQVVGGKVLNPGETILV
What are the official names of this protein?
UPF0173 metal-dependent hydrolase EF_1371.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: HIS52_PROMM
Sequence: MITRLGLIDYGMGNLRSVQIAFERLHKALHIVRQPADLSRCDALILPGVGAFDPAMVHLEQTRLVPDLKSWVKGGRPLLGICLGLQLLFESSDEGNATGLGLLKGHVQRLPSNQGERIPHMGWAALEHRNDCPLLDKEDPDSWMYFVHSYAAVPSQNSDLAAIAPFGRDNITAMVWKGRLGACQFHPEKSAAAGERMLRRWLNWLETGAKPVP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH 2, IGP synthase glutaminase subunit 2, IGP synthase subunit HisH 2, ImGP synthase subunit HisH 2, IGPS subunit HisH 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TET20_ARATH
Sequence: MRHNCCHVSFASILKILNFLQAFIGISIIIYSIWMLDQYNHHVPVDPPPSQPPAASSPDSSYSFSNSIIEINSVSDSLKNPIDFVSGIVLGSGGGDSGFNLRSLDLPAPWFIYCFMAIGILVCIVTIIGFIAAEAINGCCLCFYSILKTLLIIIEAALVGFIVIDRHWEKDLPYDPTGELNSLRAFIEENIDICKWVGIVVVAIQLLSLLLALVLRAMVSPRQSELDDEDDFENPMSRARDNLLGPQANQTSSGSSNIDNWRSRIREKYGLINSQSHTPSA
What is the function of this protein?
Promotes intracellular multiplication of tobamoviruses, probably being a component of the replication complex.
What are the official names of this protein?
Tetraspanin-20, TOM2A homologous protein 1.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: METK_BACFN
Sequence: MGYLFTSESVSEGHPDKVADQISDAVLDKLLAYDPSSKVACETLVTTGQVVLAGEVKTGAYVDLQLIAREVIQKIGYTKGEYMFESNSCGVLSAIHEQSADINRGVEREDPMNQGAGDQGMMFGYATNETENYMPLSLDLAHRILLVLADIRREGKEMTYLRPDAKSQVTIEYDDNGTPVRIDTIVVSTQHDEFILPADNSAAAQLKADEEMLAVIRKDVIEVLMPRVIASINHPKVLALFNDHIIYHVNPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYAARHIAKNLVAAGVADEMLVQVSYAIGVARPINIYVNTYGRSNVKMSDGEIARKIDELFDLRPKAIEDRLKLRYPIYSETAAYGHMGREPQMVTKHFQSRYEGDRTMEVELFTWEKLDYVDKVKAAFGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUX1_HUMGT
Sequence: MRTAKFATLAALVASAAAQQACSLTTERHPSLSWNKCTAGGQCQTVQASITLDSNWRWTHQVSGSTNCYTGNKWDTSICTDAKSCAQNCCVDGADYTSTYGITTNGDSLSLKFVTKGQHSTNVGSRTYLMDGEDKYQTFELLGNEFTFDVDVSNIGCGLNGALYFVSMDADGGLSRYPGNKAGAKYGTGYCDAQCPRDIKFINGEANIEGWTGSTNDPNAGAGRYGTCCSEMDIWEANNMATAFTPHPCTIIGQSRCEGDSCGGTYSNERYAGVCDPDGCDFNSYRQGNKTFYGKGMTVDTTKKITVVTQFLKDANGDLGEIKRFYVQDGKIIPNSESTIPGVEGNSITQDWCDRQKVAFGDIDDFNRKGGMKQMGKALAGPMVLVMSIWDDHASNMLWLDSTFPVDAAGKPGAERGACPTTSGVPAEVEAEAPNSNVVFSNIRFGPIGSTVAGLPGAGNGGNNGGNPPPPTTTTSSAPATTTTASAGPKAGRWQQCGGIGFTGPTQCEEPYICTKLNDWYSQCL
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase, Beta-glucancellobiohydrolase, Exocellobiohydrolase I, Exoglucanase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.