PharMolix/UniProtQA huggingface dataset:
Protein: PPTC7_MOUSE
Sequence: MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGGGGSSGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPVGILTTSYCELLQNKVPLLGSSTACIVVLDRSSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQRTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD
What is the function of this protein?
Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (By similarity).  Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity).
What are the official names of this protein?
Protein phosphatase PTC7 homolog, T-cell activation protein phosphatase 2C, TA-PP2C.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PYRB_LACGA
Sequence: MEKLNLVSLPHFVSVENLSAEEVEALINRAEYFKNGGATPRLTQPVYISNMFFEDSSRTHTSFEMAERKLGLTVIPFDPAHSSVNKGETLYDTSLIMDAVGVNIEVIRHSQNEYYQDLIHPKKHQHLNIGVINAGDGSGQHPSQCLLDMMTIHEHFGHFKGLKVAIVGDITNSRVAKSNMELLTRLGAEVYFSGPEYWYSSEYDKYGKYEKLDKLIPEMDVMMLLRVQHERHSDDPNEKNFDAQAYHEEYGINHKRYQELKPDTIIMHPGPINHDVELSGDLVESDKCMFTRQMQNGVFMRMAMIEAVLRGRKLGGLN
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RFA2_RAT
Sequence: MWNSGFESFSSSSYGAAGGYTQSPGGFGSPTPSQAEKKSRARAQHIVPCTISQLLSATLTDEVFKIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSGENTVVPPETYVKVAGHLRSFQNKKSLVAFKIIPLEDMNEFTAHILEVVNSHLMLSKANSQASVGRPSMSNPGMGEPGNFSGNNFMPANGLTVVQNQVLNLIKACPRPEGLNFQDLRSQLQHMPVASIKQAVDFLCNEGHIYSTVDDDHFKSTDAE
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.  In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation.  Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response.  It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage.  Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair.  Also plays a role in base excision repair (BER) probably through interaction with UNG.  Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage.  May also play a role in telomere maintenance.
What are the official names of this protein?
Replication protein A 32 kDa subunit, RP-A p32, Replication factor A protein 2, RF-A protein 2.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Protein: Y273_TREPA
Sequence: MLPYAEVILFLIKKHCIDCGEAFFGIVVLNALCLAGVGYSLLWHQGPGRSVLFVLVLATLYACLCAFCVVRGERGCDTLADTNLRVFTHALREVWLQSLWCALLQCVLFRTGKYVCTYYFARTHSVFTACGILSAWTYALACGALLWFVPVRARYRTHFRQCVYLSARVFFEHPCITFLMVLYSMGVLALSVPMAFLFPGPCGIVLLWQDVLRTLCFRRAWLAAHEGRKAACAPPIPWEQLMCQMRAQSRAHTVGELFSPWKS
What are the official names of this protein?
Uncharacterized protein TP_0273.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECF_STRP4
Sequence: MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIYFLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQARLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQRNTYLKSDQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEELSISYQSSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFGSQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTFITTTSLDHLQNLPENLSIFTIQDGKAAVNGN
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_BACMK
Sequence: MKDYLVKALAFNGEVRAYSVRTTNTVSEAQKRHDTWRTASAALGRSLTAGTMMGAMLKGEQKLTIKVEGNGPIGPILVDAHANGDVRGYVTNPHVDFEGTEQGKLRVYQAVGTEGFVTVIKDIGMREPFIGQSPIVSGELGEDFTYYFAVSEQTPSSVGVGVLVNGDDSVLAAGGFILQIMPGAQEETISFIEERLQQIPPVSQLIEQGLSPEELLYEVLGEDKVKVLETMDVQFNCTCSRERIESVLISLGKAELEQIRAEEEETEVHCHFCNERHKFAKEDITSLIEKL
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURK_VIBVU
Sequence: MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEYVDVITAEFEHIPHDVLAICQASGKFLPSSEAIKAGGDRRLEKALLDHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGKGQWRLKDAAQIETLWQEMAACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYVGVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRETSMINILGEDTLPASVMAMDGCHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVLDEKAFPAVHEFAKKWQA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
What are the official names of this protein?
N5-carboxyaminoimidazole ribonucleotide synthase, N5-CAIR synthase, 5-(carboxyamino)imidazole ribonucleotide synthetase.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: LNT1_TREPA
Sequence: MRIEEWCRSRLGEFLLFVLAVSLFALSHPNPLLPRGCALLAYGALAPLFLLVRWASGFAVVFWGGAYGAFSYGAFSYWLFVFHPVALCVVAGFSALFLAALCLALKAGGAFWQRRALLVQCLVWLGYEYAKTLGFLGFPYGVMGYSQWRVLPLIQVASVFGVWVVSALVVFPSAWLASVLGQWVEESERNARAFLSAAYSHWVSALVWVGLCGFCVCAAKAGWWPDCTAHTRAKVALVQPNGDPRRGGIESYRADFSTLTYLSDWALERYPDVDLVVWPETAFVPRIDWHYRYRHEQQSFQLVCDLLDYVNAKNCPFIIGSDDAYKKRTKEGNWERVDYNAALLFIPGVNVLPPSPQRYHKIKLVPFTEYFPYKRVFPWFYNFLEKQDARFWAQGSEFVVFEARGLKFSVPICFEDAFGYITREFCARGASLLVNISNDSWAKSLSCQYQHLSMAVFRAIENRRALVRASTSGQTVAIAPDGRILDELQPFAPGVLVADVPIVTCACGGYRYWGDALGVFFCVASLFILIAGGVRHMLRCRRGGWR
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase 1, ALP N-acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NB_MYCA9
Sequence: MTEPDPAAAEQRPSVGRNLPTFQDLPIPADTANLREGPDLNAAMLALLPLVGVWRGEGEGRDTDGDYRFGQQIVVAHDGSDYLTWDARSWRLDADGQFEQLTLRETGFWRFAPDPNDPDENQAIELVLAHAAGFVELFYGQPLNASSWELVTDALARSKSGALIGGAKRLYGIVDGGDLAYVEERVGADGGLEPHLSARLSRFAG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: WNT3_MOUSE
Sequence: MEPHLLGLLLGLLLSGTRVLAGYPIWWSLALGQQYTSLASQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCVFHWCCYVSCQECIRIYDVHTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).  Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis (PubMed:10431240).  Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development (PubMed:12569130).
What are the official names of this protein?
Proto-oncogene Wnt-3, Proto-oncogene Int-4.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: LIPL_LYSSC
Sequence: MKSILQQPIWRYYDQSISAKQRSPLESFATDDTLCQLVGQLVSPPTIRTWVHEASVVLGIQDHRLPYVQQGMDLLESRGYQPIVRNSGGLAVVLDEGILNISIVLSEQMDSLSINDGYDVMVDLVKGLFPEVAEKIEAYEIVGSYCPGSYDLSIEGKKFAGISQRRLRQGVAVQIYLCIEGSGSQRAALIRDFYEESLQQEETKFNYPQIVPEVMASLSELVDLHLTVEGVVIRLQQLLHRLAGEVHPESFHDEELTLYGFYLKRVFERNAKMLERHE
What is the function of this protein?
Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.
What are the official names of this protein?
Octanoyl-[GcvH]:protein N-octanoyltransferase, Octanoyl-[GcvH]:E2 amidotransferase.
What is the protein family that this protein belongs to?
Belongs to the octanoyltransferase LipL family.
Protein: RM21_BOVIN
Sequence: MAAAVAARALPVTFGRLAFACSRSVLRASGPGAASQWSASRRFSSQSASSPQGYVPKTSLSSPPWPEVVLPDPAEEARHHAEVVEKVNELIAGGQYGRLFAVVHFASHQWKVTSEDLILIENKLDIACGERIRMEKVLLVGADDFTLLGRPLLGKDLVRVEATVIEKTESWPRVNMRFQKRKNYKRKRIIVNPQTVLRINTIEIAPRLC
What are the official names of this protein?
39S ribosomal protein L21, mitochondrial, L21mt, MRP-L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GAL1_CALS4
Sequence: MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRDDKKVFMASLNFDLKVEVDLDSIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIPVGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAENTFVGVNCGIMDQFAVGMGKKGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKALPVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIESHNSLRNDFEVTGKELDTLVEEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVTRNYTQKIGYAPTVYVTGVGEGAGEVEYLRR
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_STAAT
Sequence: MTQTVNVIGAGLAGSEAAYQLAERGIKVNLIEMRPVKQTPAHHTDKFAELVCSNSLRGNALTNGVGVLKEEMRRLNSIIIEAADKARVPAGGALAVDRHDFSGYITETLKNHENITVINEEINAIPDGYTIIATGPLTTETLAQEIVDITGKDQLYFYDAAAPIIEKESIDMDKVYLKSRYDKGEAAYLNCPMTEDEFNRFYDAVLEAEVAPVNSFEKEKYFEGCMPFEVMAERGRKTLLFGPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGAQKEVIKLIPGLENVDIVRYGVMHRNTFINSPDVLNEKYELISQPNIQFAGQMTGVEGYVESAASGLVAGINLAHKILGKGEVVFPRETMIGSMAYYISHAKNNKNFQPMNANFGLLPSLETRIKDKKERYEAQANRALDYLENFKKTL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_ECOBW
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL34_ANAPZ
Sequence: MKRTFQPSRIVRKRRHGFRARMSTKWGRRILNRRRAQGRSILCA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ICP47_HSV2S
Sequence: MSSLYLATVDAFLRNPHTRHRTCADLRRELDAYADEERREAAKAIAHPDRPLLAPPSAPPNHSHLAARETAPPPAATP
What is the function of this protein?
Plays a role in the inhibition of host immune response.  Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules.  Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation.  In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
What are the official names of this protein?
ICP47 protein, Immediate-early protein IE12, Immediate-early-5, Infected cell protein 47, US12 protein, Vmw12.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US12 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: 5DNU_VIBVY
Sequence: MQESHFFAHLARMKLIQRWPLMRSVSSENVSEHSLQVAFVAHALALIKNKKFGGHINAERVAVLAMYHDSSEVLTGDLPTPVKYYNPEIAKEYKKIEAAAEQKLLSMLPEEFQEDFRPFVISQQTSEEEAQIVKQADSICAYLKCLEELSAGNHEFALAKKRLDITLAERKTPEMDYFLNTFAPSFELSLDEIS
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase VV1113, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PREX2_MOUSE
Sequence: MSDESAREVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIEEILIVHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRRHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGYRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDGAGDAFECKVEDVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERIEHVCHRISSYGRFSRVLKNRAWPTFKQAKPKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSVEPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLQYLLKEEDLETQDIYHKLLGKLQTALKEVEMSVCQIDDLLSSITYSPKLERKTTECVTPMDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPISVRISHDKQDKIHTCLEQLFSQIDSIINLLKGQAVIRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSSIQALAQSIRKHAEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETCEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEDPLVANVPLTYQVEGSRQALKVYFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNTTSKAAYIDKLMKPLNALDELYRLITSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQTITLARSHGLPPRYIMQAMDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE
What is the function of this protein?
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP.  Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein.  Mediates the activation of RAC1 in a PI3K-dependent manner.  May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity).
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, P-Rex2, PtdIns(3,4,5)-dependent Rac exchanger 2, DEP domain-containing protein 2.
Protein: YIDC_ECO57
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQGKLISVKTDVLDLTINTRGGDVEQALLPAYPKELNSTQPFQLLETSPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTKTFVLKRGDYAVNVNYNVQNAGEKPLEISTFGQLKQSITLPPHLDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNISSKGGWVAMLQQYFATAWIPHNDGTNNFYTANLGNGIAAIGYKSQPVLVQPGQTGAMNSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNPH_ACIBY
Sequence: MRIDQRALDQLREVKITRNYTRYAEGSVLVEFGHTKVLCTASIDNSVPRFLKGQGQGWVTAEYGMLPRSTHSRCDREAARGKQTGRTQEIQRLIGRSLRAMVDLKKLGENTITIDCDVIQADGGTRTASITGAAVALVDAMNVLLAQKKIKQDPLKGLVAAISVGMYQDEVLLDLCYEEDSNCQTDLNVVMTQAGEFIEIQGTAEDKPFTRAQSNAMLEMAEKGIAELIKKQQEALGW
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RPOC1_HELSJ
Sequence: MKYFIIRSLINKSKNFYNTIIKYNKTKLFALELSIISPQEIQNSAEYKREDGSIVGKVEDSTFYDLEKVNNKNLFSQQIFGPLIDFTCACGKKLNRKNKEINVCTKCGIEFLPSSIRSKRKGYIKLNYAMLHPFYIDYCEKLLMKSKKSLHLLLNMDSFFYFPSYKNWVNFLSEKNHIYLFLLKKILIYNRYSYIYKYSTFFKNRSKFPNNKKMNKLFFYNALGFYGLNSRKTWTVLDFIKGYNFFLGNFSKYYKKLSWYAYQQKISLNKYKSNNISINNFIDNTFNFYKNEVNSLCFKVGGDGIEMFFLQDMAVYSIINKFLKLRVLKLNNLINVNNKYYGKINTIIQNSKNYQYYFKHFYLKKIAPVWMTLRRIPVLPPNLRPILDLSGKNYQKTASSGTLLFMRDIMHEGNLFISDINTFYREIIIHNKKAFNFFSSLPTLYYLNELNIEYVNSKLWLLKYYLMPIQKSITSLFDKNPETINNFSNKKFTDLILDNVKPTSILDSLKGKYGKIRFNLLGKRVDYSGRSVIISAPHLKIYECGIPYEMALTLYYPFLSEYFYKKNNNILKKNYNKSELVLYSKSLIFTKSLQSILLSHPIIINRAPTLHRLGIQSFLPKLTHSKAIELHPLVCPAFNADFDGDQMAIHVPITEIAKLEAIQLMASSLFVYAPASGLPLLIPTQDIILGFNFYTNDLLLKTSREDKSIKQAMNQGFINECHIPYWIKINTKDIFFKFLAYPLRNYIIPIELQLNIKGFSKIIRLNTFKVTNLVFDSLDLLIKKNYISNWLILNNTKFKYLLISFLQNKNLLTNKQVYLRTTLGNIYFNKYLNL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid.
Protein: GACM_DICDI
Sequence: MSSFIGWKKNSNSGGTPGASPTSSSPLNSTISNANSVSGLGPLGSISNTSSSSLSSSFQPIQIVNSNNNSPPLSSSSSSTSTYSTPNSSNDTIGKSSSSSVASAAAAGASSTSTYSSSSSLIDTSQFNNNYVGNIFGGQPINPNTEFGSSILNKFSKYLLNKGFNTEGIFKPHPELDNEIQNVKKNLIKDLSIGDMEQASLSTLTQNPLVIGEIMKQYLALLPEPLFSYQLYDSFLLTHSILSPTDRIWAYRFLLLYLPVGFRGAIKSVLGLLSRVHQCSESSKMNSESLAKIFSPVFLRPAEDMYYMKSDQSTLEEIVKLWIEEFDMISKPPTNPNPNSKVTILGTNNTLSQLQQQSNQHSSLPNISSLSSNLIQQQLQQQQQQQQQSHPTIGMSKITSSLSSSSLQVNLQTSPKSPQSPKLLLPTIPKDDQQQMTIVKQKPILSKPTPTTTPTLTPQTTNPPPVPASTLDNNNSNNNNNNNNNNSNNNNNNNNNNNNNNNNNNNITPNGSPLINKRLSIGGFALSPPGASTSFSSLSEQEVEDKVRKIKVSIDTMVSEQALLLIKNLLKSIEKEFNYNHIIKFSSIIRDAKKHMNESSEKQLSLTKANIREFIQEYPKPMSYNLLVSSIPKLDTTNFTEQEKKANDIKRASQVAADEISDYIYYFKLKISTFQLKEQVISTAQIFSKLKSILESPPPSLPTGSSWSDFENNSSNNNININNNINNSSSNNNNNNSSPNSSPLMGRLKTSNGLNSSSNSNVTPPTENQISADKATIRIIEVCSQEIKSRFGSMRSNLERVDINGAFEIGKHSRNVKAVLNDIYVQCKLIPPPDIKALPPGEDQLTTLRKALPPLFDRFVTQIDELTQHVFNNKASPEEITIIVDKLLFINRSLSM
What is the function of this protein?
Rho GTPase-activating protein involved in the signal transduction pathway.
What are the official names of this protein?
Rho GTPase-activating protein gacM, GTPase activating factor for raC protein M.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_ARTS2
Sequence: MKSNTHPKYEAVVFNDLASGVKFLTKSTVSSKKTIEWEDGNTYPVIDVEISSESHPFYTGKQRIMDSAGRVERFNARFKGFGGKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: KLH38_HUMAN
Sequence: MDEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQCIPRTSGLP
What are the official names of this protein?
Kelch-like protein 38.
Protein: BUD13_MOUSE
Sequence: MAAAPPLTKAEYLKRYLSGTDAGLEGGPEAGRKRRKKRPKPGGAGGKGMRIVDDDVGWAAISTAKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHGEDGHFHHDDQDSSPPRRVRHDTPDTSPPRKARHDTPDPSPPRKARHDTPDTSPPRKARHDTPDPSPPRKARHDTPDPSPPRRVRHDTPDLSPPRRVRHDTPDLSPPRRVRHDTPDPSPPRRVRHDLDASPPRKSHRNSSAVSPRRGHHGSLGTSSPRQTHNHSPTAAQHRRTLDSSGTQHLRRAHHESPDLELHKAKSSKAAERAPSKAASQSGLGPSHPSLSTNSKYEHDSDLSPPRKRQAKAHFEAKKQLDSKGVYQKASDSDLSPPRKKKNSGHQDSDSDLSPPRNRPRRQSSDSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKTAHMYSGAKTGLVTDVQREHQELKKQDQDTTDLGAQFEFTETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVKPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM
What is the function of this protein?
Involved in pre-mRNA splicing as component of the activated spliceosome.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
BUD13 homolog.
What is the protein family that this protein belongs to?
Belongs to the CWC26 family.
What are the subcellular locations of this protein?
Nucleus.