PharMolix/UniProtQA huggingface dataset:
Protein: G1PDH_PYRHO
Sequence: MHLMEFPREVILGKNLIQEINNVIKRLKLGSPGLVVYGPITKKIAGSNVEKIVKEEFEVYSITVKEAHINEVERVISKIRDKGIKWAIAVGGGSIIDVTKLASFKMGIPFISFPTTASHDGIASANASIKGLNVKTSIKAKPPIAVIADIDVIKTAPKRYLAAGVGDIVSNITAVRDWKLAHKLKGEYFSEYAASLSLMSAKMVIRDAEIIRLGQDEGIRKVVKALISSGVAMSIAGSSRPASGAEHLFSHALDMLLDKPALHGEQTGIGTIIMAYLHGINWKKIRDTLKIVGAPTTAYELGIDPEIIIEALTIAHTIRPERYTILGKEGITREAAEKAAKITGVI
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_STAAB
Sequence: MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: YNJF_ECOLI
Sequence: MLDRHLHPRIKPLLHQCVRVLDKPGITPDGLTLVGFAIGVLALPFLALGWYLAALVVILLNRLLDGLDGALARRRELTDAGGFLDISLDFLFYALVPFGFILAAPEQNALAGGWLLFAFIGTGSSFLAFAALAAKHQIDNPGYAHKSFYYLGGLTEGTETILLFVLGCLFPAWFAWFAWIFGALCWMTTFTRVWSGYLTLKSLQRQ
What are the official names of this protein?
Inner membrane protein YnjF.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSUB_ALBFT
Sequence: MTTNSVTSGRRGEPLVLRDLSKRFGAREVLRNTQLRVEPGQFIAIVGRSGCGKSTLLRLVAGLETASAGSITVNDKLLTGLSDDTRIMFQDARLLPWKRIIDNVALGLPKDRRAEALKVLDQVGLADRANDWPARLSGGQRQRVSLARALVHKPRLLLLDEPLGALDALTRIEMHRLIEDLWRASGFTALLVTHDVQEAVALADRVILIEDGRIALDETVSLARPRSQGDAAFAALEKRILDRVLQKPAAPERESFTHPNDGEPRWPGVPAHGVRWAV
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIHI_ACTPJ
Sequence: MSRTKKTRRITDIMPARKADKKPEQPKLSGGKNRKSTRYELDAKAREEKKKRKHKGLPTGSRNVDPAEQKKAAVKEVKDPRIGSRKKIPLMVEFVNKPEKGQIIKPVAMEEYKPHLSPELELEQLENNEILNQLLDEIEAGKTLSAKDQKFVDECLDRIDELMTELGIQDEDEDNGDALLRQFETMDINQFR
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: PUR72_BRADU
Sequence: MTTMLSSDLPLPKIGRGKVRDIYAVDDDRLLLLTTDRISAFDVVMGETIPMKGAVLTQISAFWFGELEGVVPHHMISADTDEIIAAVPALKPHRAEILGRAMLSRRTTVFPIECVIRGYLSGSAWKEYATSGTLAGEKLKAGLVESEKLEPAIFSPATKAETGHDENITIARMREVVGDETAYTLESMTRAIYTLGEELAREQGIIIADTKFEFGRDKDGRIILIDEVMTPDSSRFWAVDAYKPGQPQASFDKQPLRDYLDVERRAGRWNGDAPPPPLPASVVEATSKRYLEAYRRVTGKELKI
What are the official names of this protein?
Putative phosphoribosylaminoimidazole-succinocarboxamide synthase B, SAICAR synthetase 2.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: VP2_BTV1A
Sequence: MDELGIPIYKRGFPEHLLHGYEFTIDSSTKIQSVGGRHDVTKLPEMNAYDIKSEGMRTALWYNPVRNDGFVLPRVLDITLRGYDGKRAVIDSSRHKSFHTDERWVQWMMKDSMDAQPLKVGLDDQTQKIAHSLHNCVVKIDSKKADTMSYHIEPIEDSLKGCLHTRTMLWNHLVRVEMSHAAQEIAYALKPTYDIVVHAERRDRSQPFRPGDQTLINFSRGQKVQMNHNSYEKMVEGLAHLVIRGKTPELIRDEITKLDEICNRWIRSRYDPGEIKAYELCKVLSTVGRKMLDQEKEPADEANLSIRFQEAIDNKFRQHDSERLKIFEHRNQRRDEDRFYILLMIAASDTFNTRVWWSNPYPCLRGTLIASETKLGDVYSMMRLWYDWSVRPTYIPYEKSREQEKYIYGRVNLFDYVAEPGTKIIHWEYKLNQQIKDITYEQGNPCDLFPDDDEAIVTKFDDVAYGQMVNDLINGGWDQERFKMHKILKSQGNVLTIDFEKDAKLTSNEGVAMPEYFDKWIIAPMFNAKLRIKHGEIAQRRNDDPMVKRTLSPIAFAPIVLQRLTLARFYDIRPAIMGQALSRQQGQSTYDEEISKIEGYAEILQRRGIVQIPKKPCPTVTAQYTLERYALFLINILEQHIIQSTDEDVMYSHPRVDYKLEVHGENIIDISQIVIFVFDFLFERRRTVRGVYESRYMVTRIRDAQGQNRINVITEFFPTFGYHLSRVKEATIIQEIMYLNFLPLFFLVSDNIIYTHKQWSVPLFLYAHELKVIPLEVGSYNDRCSLVSYIEYMVFFPSKAFRTSKLDEVQPKIAREMLKYYINTKIFEGGINLNVVTTKQLLYETYLASICGGLSDGIVWYLPITHPNKCLVAIEVSDERVPASIRASHIKLRFPLSVKHLKGIVIIQVDEEGKFTVYSEGIVSHRVCKKNLLKYMCDIVLLKFSGHVFGNDEMLTKLLNV
What is the function of this protein?
The VP2 protein is one of the two proteins (with VP5) which constitute the virus particle outer capsid.  It is the major target of the host immunogenic response.  Responsible for viral attachment to target host cell, probably by binding to sialic acid.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).
What are the official names of this protein?
Outer capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP2 family.
What are the subcellular locations of this protein?
Virion.
Protein: MDH_XANCP
Sequence: MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELSNEKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAFKDIDVALLVGARPRGPGMERKDLLLENAKIFTAQGAALNKVAKRDVKVLVVGNPANTNAYIAMKSAPDLNPKNFTAMLRLDHNRALSQLSLKLGKPVGGIEKLVVWGNHSPTMYPDYRFATSDGASIGDAINDQEWNAGTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGSNGKWVTMGVPSDGSYGIPEGVIFGFPVTTENGQYTLVKDLPIDDFSQKYIDKTLAELEEERSGVSHLLG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: FLHD_NITEC
Sequence: MGTNQILDEIREVNLSYLLLAQQMLREDRVAAMYRLGIDEDIADILIKLTNSQLLKMAGSNMLLCRFRFDDSLIAEILTSHKQDRALTQSHAAILMAGQPAEKIS
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APP_DROME
Sequence: MNLLCCCCCSNMAPNQRVTRKWELFAGRNKFYCDGLLMSAPHTGVFYLTCILITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILCGPMTPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLSASHMVTTSQPMMGGLGGGGIGGAGGGISIGGAELKPRFYDESNPSSSTLEGNGGAINGHGNGHGNGFDHPPPSYDLVQNGNSNSLAQLVDNEIPLVQMDIPAYTHQTATQARQYRHRHHKQRQICNGGTVSYENQLANASSEDELDDPDVVVVGSPEVVAAVAAIASNKAREMRNRSGSYSNLFDADFEAALVNSSLADNHVRGEGASSSGKPSAGAALLAAAISGKTENMYSNVLPVDNDTDPADSTLHVYSNIIDERKQQEQANNVLSSTLLCDDLDLDDPVSASCHVKRKSLGDGAEQVKSAERLRMLHDNTMIDTALDLDSLDGSSMGNNSQSCLVKSGKPNATSVTTNVAIV
What is the function of this protein?
Palmitoylates Dlish which is required for the apical cell cortex localization, total cellular level and full activity of dachs.
What are the official names of this protein?
Palmitoyltransferase app, Protein approximated.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: HSCA_PSET1
Sequence: MALLQIAEPGQSAAPHEHKLAIGIDLGTTNSLVATVQSGEARTLTDDLGEAMLPSVVRYQAGGITVGSEAVKSATQDPVNTLISVKRFLGKTQAEIEQSYGQLPYQFCQHDGALAIETAAGKISPVKASSHILAALKARAEQSFGNQEILGAVITVPAYFDDAQRQSTKDAAELAGINVLRLLNEPTAAAVAYGLDSGQEGIIAVYDLGGGTFDISILRLHQGVFEVLATGGDSSLGGDDFDSLIVDYLKQQTGVTTLSPAVLRLFINKAKACKEALSQYSTVNVGLEFDDEKHMVEVTREKLDELAIPLVKKTLRSCRRAVKDAGIENEEVLQVIMVGGSTRMPLVRSQVSEFFNKEALTSIDPDRVVALGAALQADVLIGNKPDSDMLLLDVLPLSLGLETMGGLVEKIIPRNTTIPVARAQEFTTFKDGQTAMSLHVLQGERELVDDCRSLAKFSLKGIPPMTAGAAHIRVTFKVDADGLLSVSAMEKSTGVQADIQVKPSFGLSDDQVSNMLKESMSNAKGDMQARMLKEQQVEALRVIEALEASLASDSGLLDEAQLAYLRAEIAELVKVRENAQQPNEIKTAIEKMDNASSDFAARRMDASIKKVLTGQSVDNI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RNPH_MYCTA
Sequence: MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASVTEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIAAVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLDMALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RPAB5_YEAST
Sequence: MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKFLRYNPLEKRD
What is the function of this protein?
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, RBP10 is part of the core element with the central large cleft.
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC5, RNA polymerases I, II, and III subunit ABC5, ABC10-beta, ABC8, DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
Protein: NORG_STAAN
Sequence: MKIPPQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEINTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
What is the function of this protein?
Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump.  Binds specifically to the promoters of norA, norB and norC and abcA genes.  Could also have an aminotransferase activity (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator NorG.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: ATPF_HAEDU
Sequence: MNLNATLIGQLIAFALFVAFCMKYVWPPLIKAIEERQANIANALSSAEKAKQEQADSKVLAEQEIIKAKEEAQKIIDLATKRRNEILESVQADAEVERQRIIEQGHAEIDSERKRVQEELRQKVAALAVAGAERIVGRSVDTAANNDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: KTHY_CALS4
Sequence: MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLIFPVTEMLLYASSRAQLVEEKILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNEIATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEFHKKVREGYLRLVKDFPERFILIDGMQEVLAVHKMVVKAVEEYLKGAKV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYFA_PSEAE
Sequence: MENLDALVSQALEAVRHTEDVNALEQIRVHYLGKKGELTQVMKTLGDLPAEERPKVGALINVAKEKVQDVLNARKTELEGAALAARLAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQLEVRFRPSFFPFTEPSAEVDIQCVICSGNGCRVCKQTGWLEVMGCGMVHPNVLRMSNIDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_BRUA4
Sequence: MSKAGGNKGGVKTGGRGGAGSSNLQVRVKKKAGTIKESSRRWLQRHLNDPYVHKSRQDGYRSRAAYKLIEINDRYDLLKKGQKIIDLGAAPGGWSQIAAKIVGSTDENPHVVGIDYLHVDPLPGVVLLEMDFLDDEAPQKLMDALGDKPDLVISDMAAPTTGHRRTDHLRTVHLCEVAADFAISVLKPGGHFLTKTFQGGTENELLALLKQKFRSVHHVKPPASRAESVELYLLARDFKG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_ACISJ
Sequence: MKPFLRSQLERYAQRLQELDFLLSREDIMADMQQYRSISREHAEVTQVAGRYARYQQREADLAGAREMLEDPDMAEMAQEEIHAAETELVQLEDELQRLLLPKDPDDERNAFIEIRAGTGGDESALFAGDLARMYTRYAATVGWKVEVMSANESEIGGYKEVVLRIEGQSGTGPSGSGVYGALKFESGGHRVQRVPATETQGRIHTSACTVAVMPEPDEHQAITLNPADLRIDTFRASGAGGQHINKTDSAVRVVHLPTGIVAECQDGRSQHSNKAKALQVLQARIQEKERSERAAKEAALRKGLIGSGDRSDRIRTYNFPQGRLTDHRINLTLYKLLAIMEGDLGEVLQALQHAREAELLAELGLE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_HAEI8
Sequence: MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGILVVSEEDVEHCSPESNLLIVKDPYVAYAILAQYMDSTPKAAQGIAKSAVIFDGVLLGENVSIGANAVIEEGVVLGDNVIIGANCFVGKNTKIGSGTQLWANVTVYHNVEIGANCLIQSGTVIGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQIAHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTAALTLGIDGINKRLKALEKKIS
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: HCDS3_XANP2
Sequence: MSNRLKNEVIAITGGGAGIGLAIASAALREGAKVALIDLDQGLAERSAAMLSTGGAVAKGFGADVTKAADITAAITSAEQTIGSLTGLVNNAGIAGFGSVHDADAAAWDRIMAVNVTGTFLASKAALAGMLERHKGTIVNFGSVAGLVGIPTMAAYCAAKGAIVNLTRQMAADYSGRGVRVNAVCPGTVTSTGMGQQLLGSDTSPEVQARRLAKYPIGRFGTPEDIAEAVIFLLSDQAAFVTGAAFAVDGGMTAI
What is the function of this protein?
Involved in aliphatic epoxide carboxylation (PubMed:20302306).  Catalyzes the reversible oxidation of (2S)-2-hydroxypropyl-coenzyme M (S-HPC) to 2-oxopropyl-coenzyme M (2-KPC) (PubMed:20302306).  The enzyme is highly specific for the S enantiomers (PubMed:20302306).  In vitro can also use the aliphatic ketone 2-butanone and the aliphatic alcohol 2-propanol, and shows an inherent stereoselectivity for 2-butanone reduction (PubMed:20302306).
What are the official names of this protein?
2-(S)-hydroxypropyl-CoM dehydrogenase 3, S-HPCDH 3, 2-[(S)-2-hydroxypropylthio]ethanesulfonate dehydrogenase 3, Aliphatic epoxide carboxylation component IV, Epoxide carboxylase component IV, SHPCDH3.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RS4_WOLPM
Sequence: MTTVITRKYRISRRLGVNLWGRAKDPVNKRKYPPGQHGILGFKKLSDFGKQFAAHKKFKFYYAISSKQLRRTFLDAYNRKGYTADNFIGILESRLSSVLYHSGLVPTIYSAKQLISHKHVTVNDKVVNISSYRVKPGDIIKIRERAAKIPVVVEAEQKQERKAPDYLEADSKEHSVKYLRSPQYSEVPYSADMEVNLVVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: COX2_VIGUN
Sequence: STVVGKCCKGNFGMSRFLLSNDFQRKLIVSGKESYYDHFSKRSYSSPSKAPGTESTITSTKIKMPNIGSEGFAFSSFLSTVNKNSRMINFSSCLKTPVKPEQIAANPVILKMTTELEKIPRALRWMCGGFPAIALCDAPEPWQLGFQDAATPIMQGIMDLHHDIFFFLVQILVFVLWVLSRALWCFRSKISPIPQRIVHGTTIEILWTILPSIILMFIAIPSFTLLYSMDDVVVDPAITIKAIGHQWYWSYEYSDYNNSDEQSLAFDSYMVPEDDLELGQLRLLEVDNRVVVPAKTHLRVLITSADVLHSWAVPSLGVKCDAVPGRLNQISTFIQREGVYYGQCSEICGTNHAFMPIVVEAVSTKDYGSWVSNQIQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, mitochondrial, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HIS7_CRYNB
Sequence: MSERIASVERTTSETHISCTIDLDHIPGVTEQKINVSTGIGFLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYAYAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: HRCA_CHLAA
Sequence: MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVENLMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIVKQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDGILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGALVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GPN3_DANRE
Sequence: MPRYAQLVMGPAGSGKSTYCATMLEHCQALNRSVQVVNLDPAAEHFEYPVIADIRELIQVDDVMEDDSLRFGPNGGLIFCMEYFSNNFDWLEESLGHVEDDYILFDCPGQIELYTHLPVMKQLVEQLQQWEFRVCGVFLVDSQFMVETFKFISGVMAALSAMVMLEIPQVNIMTKMDLLSPKAKKEIEKYLDPDMYSMMEDNSVALRSKKFSKLTKAICGLIDDYSMVRFLPFDRTDEEGINIVLQHIDFSIQYGEDLEVKEPKEVDEEPSNSNFDAFFQDTADS
What is the function of this protein?
Small GTPase required for proper localization of RNA polymerase II (RNAPII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 3, ATP-binding domain 1 family member C.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: YLH0_CAEEL
Sequence: MSKFYDPSQPEQSYDSPKLFGIIPIKFIVSFLQLVSIVSQILWLYSENDKIYLVLLSVGIVLNVFTVVVFIKEHKLLMRAHYYSALIFTVVPFIYAVYTFISFIELFFGDKDITFNQCSPFAYAFIFLCIYIFYLAMCRVLIKASEFQPDDMPDLDTTQGLFHYNRDAYDGGERAKLMYGEV
What are the official names of this protein?
Uncharacterized protein C48B4.10.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VE2_HPV24
Sequence: MENLKKRFDVLQDLLMNIYEQGSDTLESQIEHWQALRREAVLLYYARQNGVLRLGYLPVPPLATSEAKAKQAISMVLQLQSLQQSPYGTEKWTLVDTSIETFKNTPENHFKKGPINVEVIYDGDPDNANLYTMWKYVYYMDDNDQWQKTESGANHTGIYYLIGEFKHYYVLFADDANRYSKSGQWEVRINKETVFAPVTSSTPPDSPGGSRELPGSTANSKASSPTQQPQQACSDETTKRKRYGRRESSPTDSRCRRRSSSRQKKQGRRARSRTRSRCSSTQTRSRSTSRRSRSTSRGNRRCRGDTPRGQRGVSTSSRGRGRGSRRSSSSSSPTPRTKASQRGCDTRSVRDSGISPGDVGRKLQTVSGRNSGRLGRLLEEALDPPVILLRGGANTLKCFRNRAKLRYRGHYKAFSTSWSWVAADGTERLGRSRLLVSFTSFKQRSGFLDLVRFPKGVDWSLGSFDKL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.