PharMolix/UniProtQA huggingface dataset:
Protein: ATI2_PSHV1
Sequence: MSTKSSPARGTVYIPGHAMTLRSVELKKIPIKVLKTVFENAQKISPVWSLEQASLNSLAATAETMLPGPILGPSRAEHFNGPDPTIPDKMVVRMVEGDHKMLFRATLDDTYHILVTRIRVREKFVQRLARAMYTRRASMLMDVELPFKDKMEGVYAAADLEAICKMHYWVFPHTVPAPNMKSPDDKAYLTSVAQFARSTKFIESYMYYMRPHDPEVNSTDTGNRVAAMLIYIHGMQCKLASLFDALDAAILRSKFNAGSRGHSLSGIYGFTRNGKGTMMAAKSSGNVVEQIRRTCPFGSDAMVECLISALDRMTYLVARWELMSVDKRDDAKAAIAAGMGLAWLLNGHLSYLTNMIMTVYVLWLPEHYLNPRLILTISSRVLLGQLLCTSHTTFRENATCPKMLLAQNAVEWKKQERGTAAWLDYVCARAWLRASRENRKPANITAMNNTLEEISAHVLKILEEAPQPAASAPSSLCATNYCPDSPPSRPPPPPPVQKRAKDPGRFSRIMAGDDRRASVQSREDGSGYMTCEHTASTSTKLRGRVLSAPLIRHRRKSAEGLQGAAKLRGGSLRLPDNGGRAALPSEPPPSSESTDTSPEARPETDHK
What is the function of this protein?
Abundant tegument protein.  Trans-activates the immediate early genes (By similarity).
What are the official names of this protein?
Alpha trans-inducing factor, Tegument protein UL46, Tegument protein VP11/12.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 VP11/12 protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cell membrane; Peripheral membrane protein.
Protein: H2AX_HUMAN
Sequence: MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
What are the official names of this protein?
Histone H2AX, H2a/x, Histone H2A.X.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
Protein: SEM4_CAEEL
Sequence: MNELLAEMAAVSSRRKQSKPRRMSGEGDAMMSPIDLSTKSFDENNCEKGAGGALPLEDRSNILPHFSVPFANPQQFLSLCAQLGNSSSRNVSSTASTTSSCPIQSCSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFSNGQDIREHKCQKTLASRSTSVPPSTIPSSVCFLSTPTTPCLQFSINESIGTSEIREEDEEEDMDVEDGEHVANQLFGHLLQKSDDKSKMASLFNHAFPPFAAFPNMPPPFLMRQPFDPRADVFAAGRHDNDDDWEALMEISTSDEAEKIRALVGDKAVPTTDPNQCILCRRVLSCKSALQMHYRTHTGERPFKCKICQRAFTTKGNLKTHMGVHRSKHSFRGLPISLPPQLAAMHQHQHQIAPPQRIHIHNPPTSAASAAAAVAQIQASQQCPICQQRFLNAGELAVHITEHRNSLTQPPRVMPTPTTTRVQTFPFVPFFTTPPSLNATDMSTQFNLANILSAQLKNDSSPNTDTSSVEEKITRDDPPKMASLSPSNSSDSSSSVRQDILESSEFEEKLKKLEEPPILEQQVSTTPNPKNENPLLAMQKMWAETEPPPPRQMPVLSKHQCGVCFKHFSSSSALQIHMRTHTGDKPFKCDMCGRAFTTRGNLKVHMGTHSWQQSPSRRGRRIFDVASSVTEKPMLQSPILPTSGAPGASPLAMLGPNGLSGLEMMMMLWRTVCSVCQKVCQSPNELEQHLKEHLNNGSSAAPTPLASAATPPPS
What is the function of this protein?
Transcription factor, involved in positive and negative modulation of transcription (PubMed:12835398, PubMed:28614700).  Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3 (PubMed:12835398).  Involved in cell-fate regulation in multiple lineages, including neuronal, mesodermal and vulval (PubMed:8756352, PubMed:28614700, PubMed:12835398, PubMed:10926783).  Required to regulate the fate of PLM touch receptor neurons, acting via negative modulation of transcription of egl-5 and mec-3 (PubMed:12835398).  May modulate gene expression by interacting with different transcription factors during neuronal and mesodermal cell development (PubMed:8756352).  Promotes the proliferative sex myoblast (SM) fate, in a cell autonomous manner, acting via the SoxC transcription factor sem-2 (PubMed:28614700).  Involved in vulval cell-fate determination, acting by regulating expression of homeobox protein lin-39, and may link lin-39 to incoming signaling pathways (PubMed:10926783).  Plays a role in detoxification of reactive oxygen species (ROS), by regulating expression of transcription factor skn-1 and the phase II detoxification genes (PubMed:32718932).
What are the official names of this protein?
Spalt-like protein sem-4, Sex muscle abnormal protein sem-4, Transcription factor sem-4.
What is the protein family that this protein belongs to?
Belongs to the sal C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUS_MEASY
Sequence: MGLRVNVSAIFMAVLLTLQTPTGQIHWGNLSKIGVVGIGSASYKVMTRSSHQSLVIKLMPNTTLLNNCTRVEIAEYRRLLRTVLEPIRDALNAMTQNIRPVQIVASSRRHKRFAGVVLAGAALGVATAAQITAGIALHQSMLNSQAIDNLRASLETTNQAIEAIRQTGQEMILAVQGVQDYINNELIPSMNQLSCDLIGQKLGLKLLRYYTEILSLFGPSLRDPISAEISIQALSYVLGGDINKVLEKLGYSGGDLLGILESRGIKARITHVDTESYFIVLSIAYPTLSEIKGVIVHRLEGVSYNIGSQEWYTTVPKYVATQGYLISNFDESSCTFMPEGTVCSQNALYPMSPLLQECLRGSTKSCARTLVSGSFGNRFILSQGNLIANCASILCKCYTTGTIINQDPDKILTHIAADHCPVVEVNGVTIQVGSRRYPDAVYLHRIDLGPPISLERLDVGTSLGSAIAKLEDAKELLESSDQILRSMKGLSSTSIVYILIAVCLGGLIGIPALICCCRGRCNKRENKLVCQDQA
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with H at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: PYRE_POLNA
Sequence: MPAEGSLAQEFVQFAVESGVLRFGQFKTKAGRMSPYFFNAGLFDDGAKLGRLAQFYARQLLAEEQRSGLAFDMIFGPAYKGIPLAAAVAIELARLGRNLPFAYNRKEAKDHGEGGTLVGAKLQGRVLIVDDVMSAGTAVRESIALIQAAGATPHAVAIALDRQEKATENGLDVEHSAVQYVTRQLGLQVCAIARLSDLLQYLSEKSDSPSGGETLDGQRLKDHYQSVLAYRERYGVN
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: CYB_CYNSP
Sequence: MTNIRKSHALFKLINDALIDLPAPSNISSWWNFGSLLGICLLIQILTGLFLAMHYTSDTATAFQSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGLYYGSYIYTETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFLLPFIISALVVVHLLFLHETGSNNPTGIPSDMDMIPFHPYYTIKDMLGALIMILALLLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILALMPLLHTSKQRSMMFRPLSQCMFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVLMPLVSIVENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL34_YERPN
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKSRSRLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL11_PSEFS
Sequence: MAKKITAYIKLQVKAAQANPSPPVGPALGQHGVNIMEFCKAFNARTQGLEPGLPTPVIITVYSDRSFTFETKSTPASVLLKKAAGLTSGSARPNTVKVGTVTRAQLEEIAKTKNADLTAADMDAAVRTIAGSARSMGLNVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ALR_LACPL
Sequence: MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAGATGFCVAILDEALALRAAGFAEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAILAANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQPQSPFDFEGIFTHFATADQADDTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGRELSAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGFHVLVDGEFCEIVGRVCMDQLMVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYEIACGLAPRVPRVYID
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: FAEA_ASPAW
Sequence: MKQFSAKHALAVVVTAGHALAASTQGISEDLYTRLVEMATISQAAYADLCNIPSTIIKGEKIYNSQTDINGWILRDDSSKEIITVFRGTGSDTNLQLDTNYTLTPFDTLPQCNGCEVHGGYYIGWVSVQDQVESLVKQQVSQYPDYALTVTGHSLGASLAALTAAQLSATYDNIRLYTFGEPRSGNQAFASYMNDAFQASSPDTTQYFRVTHANDGIPNLPPVEQGYAHGGVEYWSVDPYSAQNTFVCTGDEVQCCEAQGGQGVNNAHTTYFGMTSGACTW
What is the function of this protein?
Involved in the degradation of plant cell walls.  Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin.  Active against methyl ferulate, methyl sinapate, methyl caffeate, and alpha-naphthyl esters with chains containing 2 to 8 carbons (C2-C8).  Inactive against alpha-naphthyl esters with longer chains (C10 or more).
What are the official names of this protein?
Feruloyl esterase A, Ferulic acid esterase A, FAEA, Feruloylesterase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FaeA family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_CHRGO
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLMIQIITGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDLLGALILILSLMTMVLFFPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAFLPFLHTSKQRSMMFRPITQVLYWLLVANLLVLTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKLLKWSL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: APPF_BACSU
Sequence: MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLKKGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQMVFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHEFSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFISHDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRERIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS
What is the function of this protein?
This protein is a component of an oligopeptide permease, a binding protein-dependent transport system.  This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transporting tripeptides.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Oligopeptide transport ATP-binding protein AppF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRUA_LISMH
Sequence: MTRYKAIISYDGSGFYGYQVQPNTRTVQAEIEKALTKMHKGKTVRITASGRTDTGVHAKGQVIHFDSELDITAEKFQKALQVMTPFDISFLTVEEVPDDFHARFGTVGKEYRYVVKRTKIFDPFSRDFALHYPYELDISKMKLASKRLIGEHDFTSFCSARTERDSKVRTLYSIDFYEEDDETLVIAFQGNGFLYNMVRILTGTLLDAGQGRISPDDISKALLARDRQKLISKTAPPQGLYLWRVDYE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: EX7S_LACGA
Sequence: MATKKNNFEEQLNELQEIVNKLESGNVPLEDALNEFQAGVKLSRELEKKLNDAEQTVAKLVDKDGNEKTLDPQNASAPEEE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_STAA9
Sequence: MAVKIRLTRLGSKRNPFYRIVVADARSPRDGRIIEQIGTYNPTSANAPEIKVDEALALKWLNDGAKPTDTVHNILSKEGIMKKFDEQKKAK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ULAE_SALPA
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMAKAGMVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: NHAA_HELPG
Sequence: MNVKKTENALSVTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAALGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLILAVLNRLNIRSLIPYLLLGVLLWFCVHQSGIHATIAAVVLAFMIPVKIPKDSKNVELLELGKRYAETSSGVLLTKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANAGVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSEHKDAMEVAKIAILLGSLISGIIGALYLFVLDKRAALKK
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TSAD_CARHZ
Sequence: MGKVILGIETSCDETAVSLVEDGRKVLISLLSSQVDLHRLYGGVVPEIASRRHLELIFPLLDEAFRKFPREKIAAVAVTYGPGLVGALLVGLSVAKSLSYALNVPLIGVNHMEGHIFANFLEDANPVFPALVLVVSGGHTDLIFMRGFGDYELLGETIDDAAGECFDKVGRVLNLPYPAGPVIDRLSKKGKPIYKFPVARLKEEGYNFSFSGLKTAVRVFREKNPEAKVEDIAASFQEALVRALVENTEKALKECMPAKLYLAGGVAANSRLREEFLNLGKTYNVPVHFPSLQYCTDNAAMIAAAGYHRYLSGKYAPLNLNAYPSLMLGEERY
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_KLEP3
Sequence: MDGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSNLKGALQPFTPLLVRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYVNELISRVLEHETRFSELFFDYLHCIQALAGTSGSPEPALRRFELALLGHLGYGVDFLHCAGSGEPVDDTMTYRYREEKGFIASLVIDNNTFTGHHLKALASREFPDVDTLRAAKRFTRIALKPYLGGKPLKSRELFRQFMPARKARADNTNND
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ATG7_KLUMD
Sequence: MVSDLKFAPSFQSFVDSSFFHELSRLKLDIFKLDSDEKALYTQLDLNQFTSNVLAISLRDDSFQKPDNDEHNIILKGYLLNFNTIELFKNCNKIQFIKEKGQELLQRGLENDLNEIISFYMISFADLKKYKFYYWICMPSFQSDGATYQIISSKVIASDSDISVSFIKQNVIIACVISGVIQKATPDNLKVCEKVVFKDFSHLKDIPSAVTKNILTVWSKLSPRETYTICFLRSDESSFEAEIIINNGNNPSLKVSGWEKNGLGKLAPKSIDLSSLMDPVKIADQAVDLNLKLMKWRIAPKIDLDGIRNTKALLLGSGTLGCYVSRVLLAWGVRHISFVDNSTVSFSNPVRQSLYNFEDCGKPKAQIASEALKRIFPSVESSGYQLEIPMIGHPVTNEKKQRQDYEALEDLIKSHDVIFLLMDARETRWLPSVLGRLHNKIVINAALGFDSYLVMRHGNDDDKLGCYFCNDILAPSDSLTDRTLDQMCTVTRPGVALLAASQAVELLVTYLQPTPNVLGTSPHQIRGFLNEFKTVSQSTPEYEHCCAGNKSVISALQENGWNFVRQALDDYKCVEKLSGLSKVQEEAELALEEDFDFSEDDEFVTG
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy (PubMed:26442587, PubMed:22682742).  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine (By similarity).  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes (By similarity).  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: NQRF_YERP3
Sequence: MEIILGVVMFTLIVLALTVMILFAKSKLVNTGDITVEINEDEDKSFTAPAGDKLLNMLSSHGIFVSSACGGGGSCGQCRVTIKEGGGDILPTELSHISKREAKEGCRLACQVNVKQNLKIELPEEIFGVKKWTCEVISNDNKATFIKELKLKIPDGDVVPFRAGGFIQIEAEPHTVKYADFDVPTEYRGDWDKFNLFRFESVVTEPTVRAYSMANYPEEHGIILLNVRIATPPPSVPDAPPGIMSSYIWSLKPGDKVVISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLHSKRKISFWYGARSRREMFYEEDFDQLQAENDNFRWHVALSDPQPEDNWTGYTGFIHNVLLENYLKDHPAPEDCEFYMCGPPMMNAAVIKMLKDLGVEDENIMLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NUOK_HELPH
Sequence: MIGLNHYLIVSGLLFCIGLAGMLKRKNILLLFFSTEIMLNAINIGFVAISKYTHNLDGQMFALFIIAIAASEVAIGLGLVILWFKKYKSLDIDSLNAMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TATD_PANSA
Sequence: MFDIGVNLTSTQFAKDREQVVARARDAGVTGLLITGTNALESQQAQRLAEWHPGYCWSTAGVHPHHASAWSAETANTLRRLAESEQVVAIGECGLDFNRNFSAHDQQEYAFDAQLQLAAELQLPVFLHCREAHDRFAAILQPWLPKLVGAVAHCFTGTREELEACLAMGLSIGITGWVCDERRGMELRELLPLIPAERLLLETDAPWLLPRDMHPRPTSRRNEPCFLPHIVQQVALWRNEAAETLGAQVDHNARQLFRLA
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAP5_YEAST
Sequence: MTDRNFSPQQGQGPQESLPEGPQPSTMIQREEMNMPRQYSEQQQLQENEGEGENTRLPVSEEEFRMVQELQAIQAGHDQANLPPSGRGSLEGEDNGNSDGADGEMDEDDEEYDVFRNVGQGLVGHYKEIMIRYWQELINEIESTNEPGSEHQDDFKSHSLPFARIRKVMKTDEDVKMISAEAPIIFAKACEIFITELTMRAWCVAERNKRRTLQKADIAEALQKSDMFDFLIDVVPRRPLPQ
What is the function of this protein?
Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression.  Recognizes the sequence 5'-CCAAT-3'.  HAP5 is essential for DNA-binding activity.  It may be the linchpin that binds to the subunit association domains (SAD) of HAP2 and HAP3 to bring these proteins together.
What are the official names of this protein?
Transcriptional activator HAP5.
What is the protein family that this protein belongs to?
Belongs to the NFYC/HAP5 subunit family.
What are the subcellular locations of this protein?
Nucleus.