PharMolix/UniProtQA huggingface dataset:
Protein: PAND_TRIV2
Sequence: MQRTLLLAKIHNCTLTGANINYVGSISIDQILLDKSGILPYEQVQVVNNANGQRFITYAIPAPAHSGIIELNGAAARLGIIGDRVIIMTYGQFTSEELKSYTPTVVIVDEKNRPLEVRRYDDLLSQV
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHQS_METST
Sequence: MKFAWIRPNGTWNDRKEAIVDSLESGFDHIMDLDNAETIKKLGSVTIISDKEDSDITLLGLNNKITMADIKKAQESGKEVAAYVEINNKDDELLVSKLGTVADYVILKGKNWKVIPLENIIASLQNRTSKIIVDVPNYEEAKLALETMEHGSDGVLLSSNDGNEIRKLGALIEKVSKESYDLKAATVTKVESVGIGDRVCVDTCSMMNVGDGMLVGSFASGLFLVHSETLESEYVASRPFRVNAGPVHAYVMTPENKTRYLSELEAGDEVVTLNSKGEANTVIVGRVKIEKRPLLLIEAKYKNSRIRTLVQNAETIRLVNDKGEPISVSKLKVGDKVLAYFSEAARHFGMAIEEQIIEK
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: STA5B_HUMAN
Sequence: MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
What is the function of this protein?
Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444).  Mediates cellular responses to the cytokine KITLG/SCF and other growth factors.  Binds to the GAS element and activates PRL-induced transcription.  Positively regulates hematopoietic/erythroid differentiation.
What are the official names of this protein?
Signal transducer and activator of transcription 5B.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein: RS142_MAIZE
Sequence: MSGRKKTREPKEENVLGPAVREGEHVFGVAHIFASFNDTFIHVTDLSGRETLVRITGGMKVKADRDESSPYAAMLASQDVAQRCKELGITALHIKLRATGGNKTKTPGPGAQSALRALARSGMKIGRIEDVTPVPTDSTRRKGGRRGRRL
What are the official names of this protein?
40S ribosomal protein S14, Clone MCH2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: DT3UO_MOUSE
Sequence: MLKMSGWQRQSQNNSRNLRRECSRRKCIFIHHHT
What is the function of this protein?
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.
What are the official names of this protein?
DDIT3 upstream open reading frame protein, Alternative DDIT3 proteins, AltDDIT3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm.
Protein: MFS6L_HUMAN
Sequence: MSANPRWDISRALGVAKLFHLVCGVREACVTPFLTLYLRQLGLAAPWVGTLMGTKHLIAAFWAPVCAFLAKSYRKRRALLIGSLLGSVGASLLMVLVPPVDKNRVHFPCNGSSGLTSTDALPGVTLPVNITSAQESASSHPAKRTAEVEMPGFRNPPGESDRETFRDLHVYLAPSVEGARTTSQALLHPVTSGLKDHPWEVTFEVVKTALPLLPGGKGPGNPANLSGTKGKAWAFDLSLEALRRTFILSLGSVAFWELLTAPLEQVADDSLYEFLDFVDATDRYRSLWVWRLLGMSAGVCGITALVGQLDCFLMTSGPRGVVHFYGYSVVSTLALLVSIAFPIPICQQWEPSYKRVKALSIVGGDPHLILLASTTVLVGAIVSTVQNFLFWHMKDHGSGELVMGFSVALSLLGEILLHPFKATLLRKLSRTGLVGLGLSCLAGQLLYYSFLWSWWSVLPIQILSAISNRALWWAVGASVEDLATPRMERALSALFRGHFYGSGCSLGSFVGGFVVMRFSLAVLYQACCVALLLWLALLLSIQRRLPRERKIKYSKLLSMEVSDTSDSEQGTEQDWLVKAMREEHSD
What are the official names of this protein?
Major facilitator superfamily domain-containing protein 6-like.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. MFSD6 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TGT_STRR6
Sequence: MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSIGGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIRLTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TIM8_CANGA
Sequence: MSNLNPGELGDLTDASKKEIAAYLDAENSKQKVRTSINQFTDICFKKCISRVDNGNLSSQEEECLASCVNRFLDTNIRVVRGLQNSQ
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM8.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RNH2_PROM0
Sequence: MQEKKEEDLQQVLNNVSEVGIDEVGRGSIFGPVFSAVVELTEKNKFTLKKLGVTDSKKLTPKKRKLLLPKILLLSSDYGIGQSSAREIDKLGIRVATELSMIRALKKLKKKPSELLVDGPLLLRPWKGTQKNIESGDSKFISIASASIVAKVSRDNLMVRLERKYSGYLIFKNKGYGTREHLSLIKKNGITKLHRKSFLKKSNLI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_TROAR
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GLYA_SODGM
Sequence: MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAELAKTHQPKMIIGGFSAYSGVVDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVEVFLSRGFNVVSGATDNHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIERTKNKVLDICDRHPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPX3_CAEEL
Sequence: MAPGSVLSLAVALATIIGISCTATVDETMRWKECLNTNQSIFDFQIETLQGEYTDLSQYRGKVILLVNVATFCAYTQQYTDFNPMLEKYQAQGLTLVAFPCNQFYLQEPAENHELMNGLTYVRPGNGWTPHQELHIYGKIDVNGDNHHPLYEFVKESCPQTVDKIGKTDELMYNPVRPSDITWNFEKFLIDRNGQPRFRFHPTAWSHGDVVTPFIEQLLAEPAN
What are the official names of this protein?
Glutathione peroxidase 3.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: SPT4_DEBHA
Sequence: MSARSERACMLCGIIQPFRKFVDFGCPNCESVLHFQDNEDNQVQDCTSPSFEGLVALGDETKSPGGERLRIDSFVAGLYAVKINGKLPPHIIGDLADQNISYRPRDGSAED
What is the function of this protein?
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT4, Chromatin elongation factor SPT4.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Centromere and heterochromatin.
Protein: PEPT_LISMO
Sequence: MKEELLKRFTKYVKVDTQSNEESTVCPTTPGQMELANILVTELKEIGMQEVTVDEFGYVMATLPSNSTKEVPVIGFLAHLDTATDLTGKNVQPQVHENYDGKDIILNKDLNVVLSPKQFPELAGYKGKTLITTDGTTLLGADDKAGITEIMVAMNHLINHPEIKHGKIRIAFTPDEEIGRGPERFDVEAFGAKYAYTMDGGPLGELEYESFNAASAKITFKGNSVHPGTAKNKMVNAVKMAMEFDARIPKDEAPEYTEGYEGFYHLISLNGDVEQARSYYIIRDFDHLKFVERKTHIASIAKELEEKYGEGSVELKLNDQYYNMREKIEPVKEIVDIVSAAMRNLDIEPKISPIRGGTDGAQLSYKGLPTPNIFGGGENFHGKFEYVALESMVKATEVIIEVARLFEEKE
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPP24_CAEEL
Sequence: MLITHLIDSLSDRAVITPLTPTSVIIYDKNELKVYVGFTNNRNSLEYTKEVVLLLSTEIPKKAEIREIIVSKNGDYVILEGPRSLFVVRIGAEILVAKPDRLPSECFCECYPLHDSLLLQNISLSVVKVRLLPEKCDEKTFVTAVLFSDNCIRFYNLQKKFDSLLLAVDFRNHLHQVHDENVANNTFGLQKALVSFDLIPPKPNTSHFSIISIDSDCDFYTSFVHFSCFKEGYAPRIHRIEPVDGLPCDPLDLRYIQTTNPRICSVFVLVSGGGVLSHLVVFPNEFGEFRFLVKDQLRLPSSNGDPRIVQNQIRSLKVSRYEIATSSSLFSVNIFPWFEALTSISPTSTLEKETRVSELVDAVIPSDELSNTTKWTGARALRAVSVQLTQSLATEEEELLPESENIMHLVILENKDGQPAHLFNISTFDNIWSTENKTSFGRDSVSQPPMKSTGSLEQQLAALKPLAACVISEKVSCEEAIDAAMKFFDAVDERLKKHCEISKLFVERCLAVSSSAQALDEKQQSVDQRLIEETNTVEELKIRMHETKERMEGARKGINVLFHRVDENVPLSDNEIRIFERLKEHQKMLSDMTKLVPKMTLDSNEIHRMANIVLKKRGTGEEQNRFAAVEKNATEIESLEARENKLNTGISELSI
What are the official names of this protein?
Protein npp-24.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TGT_STAAN
Sequence: MPAVTYEHIKTCKQSGARLGIVHTPHGSFETPMFMPVGTKATVKTMSPEELRQIEAKIILGNTYHLWLQPGNDIIKHAGGLHKFMNWDGPILTDSGGFQVFSLSNLRKITEEGVEFRHHTNGSKLFLSPEKSMQIQNDLGSDIMMAFDECPPMPAEYDYVKKSIERTTRWAKRCLDAHQRPEDQALFGIIQGGEYEDLREQSAKDLVELDFPGYAIGGLSVGEPKPVMYKMVEHTEQFMPKDKPRYLMGVGSPDALIECSIRGMDMFDCVLPTRIARNGTCMTSQGRLVIKNAKFADDLRPLDENCDCYTCQNYSRAYIRHLIKAEETFGIRLTTIHNLHFLLKLMEDIRQAIREDRLLDFKEEFFEQYGLNVENPKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: Y1814_PECAS
Sequence: MIIYLHGFDSTSPGNHEKVLQLQFIDEDVRLISYSTLHPRHDMQHLLKQVDKMIQHSDDDRSLICGVGLGGFWAERVGFLCDIRQVIVNPNLFPQENMSGKIDRPEEYLDIATKCVANFREKNRDRCMVMLSRQDEMLDSQRSAQTLGEYYEIVWDDIQTHKFKSISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein ECA1814.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: FAR1_TYRGL
Sequence: AQSFVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-1, FMRFa-1.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CATLL_PHACE
Sequence: MKLIIALAALIVVINAASDQELWADFKKTHARTYKSLREEKLRFNIFQDTLRQIAEHNVKYENGESTYYLAINKFSDITDEEFRDMLMKNEASRPNLEGLEVADLTVGAAPESIDWRSKGVVLPVRNQGECGSCWALSTAAAIESQSAIKSGSKVPLSPQQLVDCSTSYGNHGCNGGFAVNGFEYVKDNGLESDADYPYSGKEDKCKANDKSRSVVELTGYKKVTASETSLKEAVGTIGPISAVVFGKPMKSYGGGIFDDSSCLGDNLHHGVNVVGYGIENGQKYWIIKNTWGADWGESGYIRLIRDTDHSCGVEKMASYPILA
What are the official names of this protein?
Cathepsin L-like proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: MTAP_ANOGA
Sequence: MVSKVKIGIIGGSGLDDSQIIENRTERVVNTHFGIPSDVLIEGKIAGVDCVLLARHGRNHSIMPSNVNYRANIWALKTLGCTHVIVSTATGSLKEEIHPGDIVIPDNFIDRTTKRVQTFYDGNELLSGVCHIPMEPAFCNRTRDVLIETARGIGLGVHEKGTVVTIEGPRFSSKAESNLFRQWGADLVNMTLVPEVVLAKEAGLCYAAIAMATDYDCWREAGEDVNVADVLATFKKNVTKVTDLIINAIPKVAALDWSDTIEELGKTVNTSIMLPHSN
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FGD2_MOUSE
Sequence: MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSWCVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVTAIKRAASGRTPEGPDEEDVSD
What is the function of this protein?
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.  Activates JNK1 via CDC42 but not RAC1.  Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
What are the official names of this protein?
FYVE, RhoGEF and PH domain-containing protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
Protein: MTNA2_PSELT
Sequence: MSTFRSIEWKKDKLVLLDQRYLPEKTLYLELKTVDEVARAIKEMTVRGAPAIGVAAAYGMVLCVQKLSKNDDLIRELQKADDLLRASRPTAVNLFWALDRMKKIWQGFNGSLEDLKMILEKEATDIEREDVEINKQIAKNGVELVPFGAKIIHHCNTGSLATVDYGTALGVIRYAHEIGKKIHVFLDETRPRLQGARLSAWEMKELGIPHTIIVDGASGLVMKKFKIDLALVGADRIAANGDTANKIGTYNLAIVAKYHNVPLYVVAPTSTIDLKTPAGQDIPIEERSADEIRCVGNSQVAPQESPVFNPAFDVTPAELISGIITEKGIVYPPFKENLRKLFESA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase 2, M1Pi 2, MTR-1-P isomerase 2, S-methyl-5-thioribose-1-phosphate isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: IF11_BURMA
Sequence: MAKEELIELDGIVDEVLPDSRYRVTLDNGVVVGAYASGQMRRHRIRILAGDRVTLELSVYDLTKGRINFRHKDERRSDAAPRASARRR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOCD_NITOC
Sequence: MRSSLQQPTPPMAGFTPIAEILYHQFGEANFIRQETHDGVPTFWITKAQVSKILRYLKAELAPPYPMLYDLTAIDERVRTHRPGQPASDFTLVYHLLSFIRNEDLRLKVPLQGESPSLPTITPIWPAANWYEREVWDLFGINFEGHPHLSRILLPPTWQGHPLRKDHPARATEVDPFTLSEEKQAREQEALRFRPEDWGMRRASGSTDFMFLNLGPNHPSVHGVFRIVLQLDGEEIVDAVPDIGYHHRGAEKMGERQSWHTYIPYTDRIDYLGGVMNNLPYVLAVEQLAGIQVPERVKVIRVMLAELFRIASHLVFYGTFAQDVGQLSPVFYMFTDRERVFDIIEAICGGRMHPEWFRIGGVAQDLPRGWDDLIRDFLRYLPPRLAKYDKIAMNNRILKKRTQGVGSYTIAEAMEWGVTGPGLRACGLEWDFRKQRPYSGYEQFQFDIPVAQHGDCYDRCWVRIEEMRQSLRIIEQCLNHMPAGSYKADHPLTTPPRKERTMHDIETLISHFLSVSWGPVIPAGEACVGIEATKGNNSYYLISDGHTQPYRVRIRTPSFPHLQMIPLISRGSMVPDLIATLGSIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ZHX1_RAT
Sequence: MASRRKSTTPCMVLASEQDPDLELISDLEEGPPVLTPVENARAESVSSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKEENTEQGESIDVSSSGISISKTPIMKMMKNKVENKRITVHHNSAEGTSEEKENGVKASREENAENTSSSASESNTSTSTVNQVHPSPAGTVVTPTAVLPGLAQVITAVSAQQNSNLVPKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVGQPGLVLTQVAGANTLPVTAPIALTVAGVPNQTNVQKSQVPAAQPAAETKPATAAVPSSPSVRPEAALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSKSNQCLHLNNDSSATIIIDSSDETPEPPAAAASQPKQSWNPFPDFAPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKNKTKALKDEKVEVDESNVGSSKEEPGENSPGDEAVAPKSAGTGKICKKTPEQLHMLKSAFVRTQWPSPEEYDKLAEESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSSNSSSLNGLSSLRKRGRGRPKGRGRGRPRGRPRGGKRMNTWDRVPSLIKFKTGTAILKDYYLKHKFLNEQDLDELVNRSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSDTWEPPRHVKRKLSKSDD
What is the function of this protein?
Acts as a transcriptional repressor.  Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA.  May link molecule between DNMT3B and other co-repressor proteins (By similarity).
What are the official names of this protein?
Zinc fingers and homeoboxes protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZHX family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalized in the nucleus with DNMT3B.