PharMolix/UniProtQA huggingface dataset:
Protein: SYP_LACPL
Sequence: MKQSKLLIPTLKEVPNDAEALSHQMMLRAGYIRQISAGMYAYLPLAYRVLTNIEKIIRQEMEKIDAAEMLVPAVIPAELWKATGRYETYGPELFKLKNRHDREFILGPTHEETFTSIVRDEIKSYKRLPLTLYQIQAKYRDEDRPRYGLLRGREFIMKDAYSFHADEASLDDTFQDMAQAYQNIFERVGLKFRSIIGDGGAMGGKDSREYSAIAPVGEDTIVYSDASDYAANLEMARSLYVPKKSHASLKDMEKIDTPGVGTIDELAEFLKVGADQLVKSILFIADDQPVMALVRGDHEVNDVKLKNYLGADFLEMATPEQAQQYLGASFGSLGPVNVHDDVKIVADQYVKDMVNITVGANEDGHHFTNVNPERDFHAEAYVDIRFVQEGELSPDGAGVLKFTKGIEIGHIFKLGTRYSKDLHAEVLDANGRNIPVIMGCYGIGVSRLLSAIAEQRADENGLIWPKAIAPFDVHVIPVNPKKADQVEVADQVEAQLEAAGYNVLYDDRKERPGVKFADSDLMGIPARITIGKKASEGIVEIKLRQTGETLEVKQEEIANNLAVLLKNID
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOT4_MOUSE
Sequence: MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPIANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQVGGGTEPRGPQRPPQRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGFIDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTATDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTEPEEVASEEKLHKPPVDVGVDSREVEHFLKAEPEKNGEVVHTPETSV
What is the function of this protein?
Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity).  Plays a predominant role in the L-lactate efflux from highly glycolytic cells (Probable).
What are the official names of this protein?
Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction. Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells.
Protein: SEPF_RHOE4
Sequence: MSNLHKFKAYFGMVPLDDYEDEYVEEPDQARRAPRRSHDGYAERDDREFVEPAFSKASYAPSRRDEEDAEFDRYDSRPRVDTVPSRSSRPAMAPRPASRGNLAVDARAERPEARRAPVVDDGGPLAKITTLRPQSYAEARTIGERFRDGTPVIMDLVDMSNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADIDVSAEERRRIAETGFYSQK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RL10_RALSO
Sequence: MALNLEDKKAVVAEVTAQVAKASTIVVAEYRGITVGDLTKLRAQARQQGVYLRVLKNTLARRAVEGTPFAELAEQMTGPLIYGISEDAVAPAKVLNDFAKGNDKLVLRAGSYEGKVLDAAGVKALASIPSREELLSKLLFVMQAPVSGFARALAALAEKKQSEEGAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PTPA1_ASPOR
Sequence: MAADGLPVRVLPTLDPSEGHTFLEPSKRINEGDDVSEFLCSKAYVDIMTFLLQLNRSMFPAKLPDGRVQTWPLNTEAVGFSAPVRQLQQLLSKIEDLLDATPLMPGEWRYANGAFQVWHDKVKKATPSLLAECLPAEILHAPSSDPNGPTAEVELTEYFLGSWGSRERMDYGTGHELSFLTFLGAIWKLNGFPKNEPGVEERTIVLGVIEPYLELIRAVIKKYKLEPAGSHGVWGLDDHSFIPYIFGSAQLGPAISNSDLVPETGSLPDAVDPDGVTKANVVEKERKVNMYFSAIGFINDVKKGPFWEHSQMLYNISGVQAGWAKINKGMIKMYNAEVLSKFPVVQHFRFGSLFSWNRDPSAIPPPSRIHTSSGPETRPRQVPPSARQDPGPGTKAPWATASQSTPPPSTGTAAPWATSRAGREPPTTSRIPSALPDTSRLPPGPMAPTRAPWASSQPAGPAPTGDPNDITTKAPWAK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase.  Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A activator 1, Peptidyl-prolyl cis-trans isomerase PTPA-1, PPIase PTPA-1, Rotamase PTPA-1, Phosphotyrosyl phosphatase activator 1.
What is the protein family that this protein belongs to?
Belongs to the PTPA-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DTD_MYCUA
Sequence: MRVLVQRVCSAAVTVDGDVVGAVRPPGQGLLAFVGVTHGDDGDKARRLAEKLWYLRILTDEKSASDLGAPILVVSQFTLYADTVKGRRPSWNAAAPRAVAEPLVAAFAEALRALGAHVEAGVFGAHMQVELINDGPVTVMLEL
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGCN_ECOLI
Sequence: MEDDCDIIIIGAGIAGTACALRCARAGLSVLLLERAEIPGSKNLSGGRLYTHALAELLPQFHLTAPLERRITHESLSLLTPDGVTTFSSLQPGGESWSVLRARFDPWLVAEAEKEGVECIPGATVDALYEENGRVCGVICGDDILRARYVVLAEGANSVLAERHGLVTRPAGEAMALGIKEVLSLETSAIEERFHLENNEGAALLFSGRICDDLPGGAFLYTNQQTLSLGIVCPLSSLTQSRVPASELLTRFKAHPAVRPLIKNTESLEYGAHLVPEGGLHSMPVQYAGNGWLLVGDALRSCVNTGISVRGMDMALTGAQAAAQTLISACQHREPQNLFPLYHHNVERSLLWDVLQRYQHVPALLQRPGWYRTWPALMQDISRDLWDQGDKPVPPLRQLFWHHLRRHGLWHLAGDVIRSLRCL
What is the function of this protein?
Probably accepts electrons from YgcQ/YgcR and reduces a quinone.
What are the official names of this protein?
Probable electron transfer flavoprotein-quinone oxidoreductase YgcN.
What is the protein family that this protein belongs to?
Belongs to the ETF-QO/FixC family.
Protein: SEBA_ASPFU
Sequence: MDATYTMAQTPVQGQPSFAYYPTESQSRQQHFTSHPFEMQYYGQVSSYPQQQAQQQHSMPEQQPVYAAQPMLNMHQMATTNAFRGALSMTPIASPQPTHLKPTIIVQQDSPALMPLDTRFVSNDFYGFPSTPPLSTSGSTISSPPSSNGSLHTPINDCFFSFEKVEGVKEGCESDVHCELLANTDWSRSDSPPLTPVFIQPQSLTASQSSDLLSAQIPCPSLSPSPSPDSATFISHPQSILSAEPSGSDFCDPRQLTVESSVGAPAELPPLPTLSCNEEEPKVVLGSATVTLPVHEGLSPSFSSSSEDPLGSLPTFDSFSDLDSEDEFANKLVDFHPIGNTYFQGDKRQRLGTYLLDEDEFLSERSLEDLDDQEAFAQSGLPSVESTDFLAVEGDATQSTEEMSSKKRVTSRRSLKKASTSESSSDSLAKKTQASATSRSGHSDTTSTVQQSTASSRQNSTANTSNSESPAAPVSVNRRGRKQSLTDDPSKTFVCSLCSRRFRRQEHLKRHYRSLHTQDKPFECHECGKKFSRSDNLAQHARTHGGGSIVMGVIDTNSSNTQPAFDEPEPRALGLALYEAANAATSKSTTSESSDGTISDTSSVGGRPAKKRRRDDHV
What is the function of this protein?
Transcription factor that is involved in the response to heat shock, oxidative stress, and poor nutrient conditions (PubMed:22345349).  Controls expression of oxidative stress response genes such as ccp1, cat1, cat2, sod2; as well as of heat shock genes such as hsf1, hsp30 and hsp90 (PubMed:22345349).  Negatively controls the expression of the fumiquinazoline (fmq) cluster via binding to the STRE motifs at the fmqA-D promoters (PubMed:33705521).  Plays a role in virulence (PubMed:22345349, PubMed:33705521).
What are the official names of this protein?
C2H2 finger domain transcription factor sebA, Stress response element-binding protein A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Accumulates in the nucleus upon exposure to oxidative stress and heat shock conditions.
Protein: AMPP1_ASPOR
Sequence: MLFSRPPIRSPWISAFRSASQLPLSRPRFFSISLSRYSVDMETVNTSERLSRLRELMQEHKVDVYIVPSEDSHQSEYIAPCDGRREFISGFSGSAGTAIVSLSKAALSTDGRYFNQASKQLDNNWQLLKRGVEGFPTWQEWTTEQAEGGKVVGVDPALITASGARSLSETLKKNGSTLVGVQQNLVDLVWGKDRPAPPREKVRVHPEKYAGKSFQEKISELRKELESRKSAGFIVSMLDEIAWLFNLRGSDIPYNPVFFSFATITPTTTELYVDADKLTPEVTAHLGQDVVIKPYDAIYADAKALSETRKQEAGETASKFLLSNKASWALSLSLGGEGQVEEVRSPIGDAKAVKNDVELAGMRACHIRDGAALTEYFAWLENELVNKKSTLDEVDAADKLEQIRSKHDLFVGLSFDTISSTGPNGAVIHYKPEKGSCSIIDPNAIYLCDSGAQYLDGTTDVTRTFHFGQPTELEKKAFTLVLKGVIGLDTAVFPKGTSGFALDVLARQYLWKEGLDYLHGTGHGIGSYLNVHEGPIGVGTRVQYTEVPIAPGNVISDEPGFYEDGKFGIRIENVIMAREVQTTHKFGDKPWLGFEHVTMAPIGRNLIEPSLLSDAELKWVNDYHREIWEKTHHFFENDEYTRSWLQRETQPISK
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase P, AMPP, Aminopeptidase P, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: GATB_MARN8
Sequence: MQWDIVIGLEIHVQLATQTKIFSGSSTAYGAEPNTQANAVDLAMPGTLPVPNEQAFRYAVMFGLATNAEIGRRSVFERKNYFYPDLPKGYQTTQLAQPIVGPGYVDIDLADGSTKRVRIHHAHLEEDAGKSLHEDYHGMTGIDLNRAGTPLIEVVTEPDMTSAEEAVAFAKKLHSIVTSLGICDGDMSQGSMRFDVNISLKPKGSDTLGTRTETKNLNSFRFMEQAIAHEVERQMDILEDGGVIVQETRLYNGDRDESRSMRTKEEANDYRYFPCPDLLPVEIDDAFIEDARSRLPELPDARRARFKEQYGLNDYDAGILSADAKLAAFFEETVEHGKDAKLAANWIQGEFSARLNAEEKSVAEAPITGAQLGAMVTRIADNTLSSAGAKKVFEALWTGENNDVDAIIEAKGLKQVSDTGALESMVDEVLAGMPDQVAQYQNEEDPKKRKKMLGGFMGPLMKASKGQGNPKLFNEILVRKLGG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: AK1C3_HUMAN
Sequence: MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY
What is the function of this protein?
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids.  Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279).  Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942, PubMed:11165022).  Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328).  Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:15047184, PubMed:20036328, PubMed:10622721, PubMed:11165022, PubMed:10998348, PubMed:19010934).  Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:14672942, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:10557352).  Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338).
What are the official names of this protein?
Aldo-keto reductase family 1 member C3, 17-beta-hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type 2, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, DD-3, DD3, Dihydrodiol dehydrogenase type I, HA1753, Prostaglandin F synthase, PGFS, Testosterone 17-beta-dehydrogenase 5.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLL53_YEAS2
Sequence: MWFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYHWIYWISPLLGAFLAWSVWQLLQILDYTTYVNAEKAAGQKKED
What are the official names of this protein?
Putative uncharacterized protein C1Q_01798.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RGS3_MOUSE
Sequence: MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGPDGGVLRRASCKSTHDLLSPPNKREKNCTHGAPVRPEQRHSCHLVCDSSDGLLLGGWERYTEVGKRSGQHTLPALSRTTTPTDPNYIILAPLNPGSQLLRPVYQEDTIPEEPGTTTKGKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAAPPTERKMFETEADEKEMPLVEGKGPGAEEPAPSKNPSPGQELPPGQDLPPSKDPSPSQELPAGQDLPPSKDPSPSQELPAGQDLPPSKDPSPSQELPVGQDLPPRKDSSGQEAAPGPESPSSEDIATCPKPPQSPETSTSKDSPPGQGSSPTTELPSCQGLPAGQESTSQDPLLSQEPPVIPESSASVQKRLPSQESPSSLGSLPEKDLAEQTISSGEPPVATGAVLPASRPNFVIPEVRLDNAYSQLDGAHGGSSGEDEDAEEGEEGGEGEEDEEDDTSDDNYGDRSEAKRSSLIETGQGAEGGFSLRVQNSLRRRTHSEGSLLQESRGPCFASDTTLHCSDGEGATSTWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLTECDEASRKRKSKNIAKDMKNKLAIFRRRNESPGAQPASKTDKTTKSFKPTSEEALKWSESLEKLLLHKYGLEVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTREHTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL
What is the function of this protein?
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form.  Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
What are the official names of this protein?
Regulator of G-protein signaling 3, RGS3, C2PA.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus.
Protein: PDXB_SHIFL
Sequence: MKILVDENMPYARDLFSRLGEVIAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHDRTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRADRGDEGDFRSLDELVQRADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLTKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALMA_ARBPU
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEF
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-alpha, CaM A.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: IF2_ECOLI
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  May protect N-formylmethionyl-tRNA(fMet) from spontaneous hydrolysis.  Promotes N-formylmethionyl-tRNA(fMet) binding to the 30S pre-initiation complex (PIC) (PubMed:1764105, PubMed:20224578).  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.  Upon addition of the 50S ribosomal subunit, IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_LISMF
Sequence: MASEVTSAKAVAKTVRIAPRKARIVIDLIRGKQVGEAIAILKYTPRSASPIIEKVLKSAIANAEHNYDLDINNLVVEEAFVDEGPTLKRFRPRAQGRASAINKRTSHITVVVSEVKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NHD2_ARATH
Sequence: MALLFGIGYVLIIFEESLSFSKSGIALLMAVSLWVVRSIETSVEIVTLELQHATSEVSQIVFYMLGAMTIVEIIDAHQGFKLVTDCITSRKPKILLWVIGFATFFLSSVLDNLTSTIVMVSLLRRLIPPSEYRKLLGAVVVIAANAGGAWTPIGDVTTTMLWIHGHISTFSTIKNLFLPSAISLVVPLALMSLTSEVHGMGLNTPPTPLLAYDRSAPRGKLVFGVGFGALLFVPLFKSLTGLPPYMGILLGLGVIWILTDVIHYGDLERQHLKLPHALSRIDSQGALFFLGILLSMSSLDAAGILKVIANYLDAHIANVELIASIIGVVSAIIDNVPLVAATMGMYDLSTFPQDSEFWQLISFCAGTGGSMLITGSAAGVIFMSMEKVNFFWYFRKVSGFAFAGFTAGIMTYLAVHNFPL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Sodium/proton antiporter 2, AtNHD2, Na(+)/H(+) antiporter 2.
What is the protein family that this protein belongs to?
Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YEBF_SALPB
Sequence: MNKRGALLSLLLLSASVSAFAASTESKSVKFPQCEGLDAAGIAASVKRDYQQNRIVRWADDQKKVGQADPVAWVNVQDVVGQNDKWTVPLTVRGKSADIHYQVIVDCKAGKAEYKPR
What are the official names of this protein?
Protein YebF.
What is the protein family that this protein belongs to?
Belongs to the YebF family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSC_PONPY
Sequence: MPASMFSIDNILAARPRCKDSVLPVAPSAAAPVVFPALHGDSLYGASGGASSDYGAFYPRPVAPGGAGLPAAVSGSRLGYNNYFYGQLHVQAAPVGPACCGAVPPLGAQQCSCVPAPSGYEGPGSVLVSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAEKWNKTSSSKASPEKREEEGKSDLDSDS
What is the function of this protein?
Regulates chordin (CHRD).  May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis.  In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).  Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity).
What are the official names of this protein?
Homeobox protein goosecoid.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HTPX_SYNC1
Sequence: MNTLRTVALMTVLTLLLVWAGGMMGGRGGALFALIMAAVMNLGSYWFSDKIVIAMYRGREVSSGPLFSVVQELCLRNALPMPKVYILPQATPNAFATGRNPKHAAVAATEGILQVLSREELMGVMAHEMSHVRHRDILIGSIAATIAGAISYLAHMAQWAALFGGFGGRDDDDGNPLGLLLLIIFAPLAAMLVQMAISRSREYAADRGGAALCGNPHYLANALRKLEMANSRQPMPKVNEATAHMFIVNPLRGGGLKSLFSTHPPVDERIRRLENMTVL
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVC_MAGSA
Sequence: MRILGLDPGLRNTGWGIIDAVDNRLRHVADGVIRPDASAALAERLVQLHDGIMAVIADFSPDEAAVEETFVNMNPASTLKLGQARGVVLLVPAKSGLPVGEYAATLVKQSVVGTGRAAKEQVGMMVKTLLPGCLAATADAADALAVAICHAHHRGTQQKLARAVAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ULAR_ECODH
Sequence: MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGREMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSGKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPEILQQLEAQGVSILRV
What is the function of this protein?
Represses ulaG and the ulaABCDEF operon.
What are the official names of this protein?
HTH-type transcriptional regulator UlaR.
What are the subcellular locations of this protein?
Cytoplasm.