PharMolix/UniProtQA huggingface dataset:
Protein: ISPDF_GRABC
Sequence: MRIAAILVAGGSGSRFGSDIPKQFLPVGGKPLIRHGAERLSAKVDLLQPVGCADDIAPLLQGLDHLPIVDGGKERQDSVRAGLEALVPYAPDIVLIHDAARPYFPDHTIEDLIEALQIHDGAIPAVPVADTLKRAAGNIIDSTVPREGLYRAQTPQAFKFSVLLALHRDHPGGATDDAALLDQAGHSVALVPGAEDNIKVTYPADLARVERSMSISMIPRIGTGYDVHAFETGRKLILCGIEVPHHQGLAGHSDADVGIHALCDAIYGALAEGDIGRHFPPTEASWKDADSARFLRHAAERIAARGGFLANADLTLICEKPKITPHAPAMIARLAELLGVSIDKISVKATTSEKLGFTGREEGIAAQAAVIIMIPA
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: Y1770_PROMH
Sequence: MNEPTVTPPGFFKKLRLGNEYLKTWPVEKQLAPVFPENRMIKATRFGIRYMPPIAIFTLTWQIALGGDLGPAITTALFACSLPMQGLWWLGKRAATPLPAVLLNWFYEIREKFEQAGIALAPVEKTPTYLSLAHLLKRAFKQLDRSFLDDV
What are the official names of this protein?
UPF0208 membrane protein PMI1770.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WECF_SALHS
Sequence: MTVLIHVLGSDIPHHNHTVLRFFNDTLAATSEHAREFMVAGEDNGFTESCPALSLRFYGSKKALAQAVIAKAKANRRQRFFFHGQFNTSLWLALLSGGIKPAQFYWHIWGADLYEVSHGLKFRLFYPLRRIAQGRVGCVFATRGDLSYFARQHPDVRGELLYFPTRMDPSLNAMAKERQRAGKLTILVGNSGDRSNQHIAALRAVYQQFGDTVNVVVPMGYPANNQAYIDEVRQAGLALFSDENLQILSEKMEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQADIPCVLNRDNPFWQDMAEQHLPVLFTTDDLNEQVVREAQRQLASVDKSGITFFSPNYLQPWHNALRIAAGEAE
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARCC2_ENTFA
Sequence: MSLNVIALGGNAILDTDPTDEGQKAVVNHAAKYIAEFVAKGEQVIVCHGNGPQVGNLLLQQKAGESEKNPALKLDTCVAMTQGSIGYWLQNALTNEFEKRNIAKPVISVVTQVRVDKEDPSFKKPSKPIGPFYTKEEADAEAAKDGSTYVEDAGRGYRKVVPSPMPKEIVEKEAVRALVEADVLTICSGGGGIPVVAEDGQYVGVEAVNDKDFSARVLAENVDADRLIILTGVDNIYINYNQPDQKALEQISVAEAEEYIKEGHFAAGSMLPKIEAALDFVKGDDKRKAIITSIENLENIDKEAGTVISQKG
What are the official names of this protein?
Carbamate kinase 2.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBR1_CHICK
Sequence: MKVAVAGCCHGALDKMYETLELLQRRHNVRPDLLLCCGDFQAVRNEADLRCMAVPAKYRHMQTFYRYYSGEKKAPVLTVFIGGNHEASNHLQELPYGGWVAPNIYYLGYAGVVRFRGVRIGGISGIFKSHDYRKGHFECPPYNQQTIRSAYHVRNIEVFKLKQLKHPMDIFMSHDWPQSIYHYGNKKQLLKMKSFFRQEVESNTLGSPAASELLQHLKPNYWFSAHLHVKFAAFMQHETKSKEELPKATKFLALDKCLPHRDFLQIIDIEHDPTAGDSLEYDAEWIAVLKATNSLINVTQSSWSVPENNGLHAKWDYSATEEAIKEVLEELNHNLKIPCNFTLTTTCYDPSKPQKNMEPVHTINPQTTEFCAQFGLTDINDRIQQVKEEGSVRGEYEEEEEEMDSSGSAEEPSEYNTDNSGLSSINPDEIMLDDEGGDEDLSTCSVDPSPDHPPEFSASFSDIRIMPDSMAVSSDDAMDSTNEELEKSGVNKQVEEKSLNERPLKRVGGSENGNSGIKIKRRNQAIYAAEDEDEAK
What is the function of this protein?
Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover.  Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
What are the official names of this protein?
Lariat debranching enzyme.
What is the protein family that this protein belongs to?
Belongs to the lariat debranching enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNAI2_HUMAN
Sequence: MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQPEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
What is the function of this protein?
Transcriptional repressor that modulates both activator-dependent and basal transcription.  Involved in the generation and migration of neural crest cells.  Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity).  Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells.  In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.  Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes.  Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes.  Represses E-Cadherin/CDH1 transcription via E-box elements.  Involved in osteoblast maturation.  Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts.  Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts.  Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
What are the official names of this protein?
Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Protein: MATK_PHAAO
Sequence: MYQQKYLISSVSDSNQNGFSLHKNSFSYHFYSQMVSEGFGVILEISFSSRLVSSLEEKRIPKSQNLRSIHSIFPFLEDKLSHLNYVSDLLIPYPIHMEILVQILQCWIKDVPSLHLLRFIFHEYHNLNSLITSKKSIYVFSKRKKRFLWFLHNFYVYECEYIFLFLRKQSSYLRSISSGVFLERTHFYGKIEYLRVMSCNSFQRILWFLKDIFIHYVRYQGKAILVSKGTLILMNKWKFHFVNFWQFYFHFWFQPYRIRIKQLPNYSFSFMGYFSSVLKNPLVVRNQMLENSFLINTLTNKLDTIAPVIFLIRSLSKAQFCTVLGHPISKSIWTNLSDSDILDRFCRICRNLCRYHSGSSKKQVLYRIKYILRLSCARTLARKHKSTVRTFMRRLGSAFLEEFFFEEEQSLSLVFLQKIPFLLHGLNRERIWYLDIIRMNDLVDHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RBS2_NICSY
Sequence: MAFLIMSSAAAVATGTNAAQASMIAPFTGLKSATSFPVSRKQNLDITSIASNGGRVQCMQVWPPINKKKYETLSYLPDLSEEQLLREVEYLLKNGWVPCLEFETEHGFVYRENNKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVEEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 2, RuBisCO small subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NORG_STAAC
Sequence: MKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKNKAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKLGKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
What is the function of this protein?
Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump.  Binds specifically to the promoters of norA, norB and norC and abcA genes.  Could also have an aminotransferase activity (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator NorG.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: SLM1_YEAST
Sequence: MSKNNTMTSAVSDMLSQQQLNLQHLHNLQQHTRSMTSADHANVLQQQQQQQQQQQQQQQQQQQSASFQNGSLTSDINQQSYLNGQPVPSTSNSTFQNNRTLTMNSGGLQGIISNGSPNIDSNTNVTIAVPDPNNNNGKQLQGKNSLTNTSILSRARSSLQRQRLAQQQQQQQDPRSPLVILVPTAAQPTDILAARFSAWRNVIKSVIVYLTEIASIQDEIVRQQLRLSHAVQFPFFSIENQYQPSSQEDKSVQKFFLPLGNGSIQDLPTILNQYHESLASSASKASRELTNDVIPRLEDLRRDLIVKIKEIKSLQSDFKNSCSKELQQTKQAMKQFQESLKDARYSVPKQDPFLTKLALDRQIKKQLQEENFLHEAFDNLETSGAELEKIVVMEIQNSLTIYARLLGQEAQLVFDILISKLDSGFFNVDPQFEWDNFISRDPNFLLPNLPMRTFKEIVYKYQFDPLTYEIKSGFLERRSKFLKSYSKGYYVLTPNFLHEFKTADRKKDLVPVMSLALSECTVTEHSRKNSTSSPNSTGSDAKFVLHAKQNGIIRRGHNWVFKADSYESMMSWFDNLKILTSTSNIQDKYKFITQKLNLNSDGKPKLTNNHTSINKYQLSNANSTMVENDENDDINSNYVGSTVTPKLDNQTNTNTSMSSLPDTNDSELQDQVPNIYIQTPINDFKS
What is the function of this protein?
Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways.  Phosphorylated and activated by TORC2 under favorable growth conditions.  Mediates actin polarization via inhibition of calcineurin-dependent transcription.  Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin.  Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization.  Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.
What are the official names of this protein?
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1, Synthetic lethal with MSS4 protein 1, TORC2 effector protein SLM1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to cortical punctate structures. Correct localization requires phosphatidylinositol 4,5- bisphosphate and functional TORC2.
Protein: Y140_MYCGE
Sequence: MNDWQWLKNRLVNSKTKSVSFWLPQTSSNIIDIAELIKCCSELKNTSINGLIDFLNQQDKLEFNLTRLKEIDVEDGKQLFGIETSVYKHFQNEIARFYKQVNKHFRETGSESLFLALPVIEGINEFNDIFRAPLLYVGVKLKVSPRFERFWLEINKEEIFLNPTIIGVETNKRNSLFKNNYDTTKIDVNDALKVFSELEYEFRMPLTSELKSFSKKAKSDFNTEKRTNYLINNVLLGIFDVKGDQLFQNFNEILNTDPDVLDELLKDRRDLLLENREFREQFDLKDTYLFSHLDIYQQYAVKQALLGDLIIEGPPGTGKSETIVNILVNLVLNNKKVLFVSEKVTALDVVYNRLGSFKHIALFNASVAAEKKRFYNQFAEFETYFTTYFSKKDLDATLPTFEGKWVDDILGAFQALQALYDTKINSGENLFSFKEIVSSFQMLDASYIKIKEYERFDEWVRVFSNPLWLEKHLSYQELKKELSQRWNGIDNFYQLQSLLNQTKKRKVLNYVLEHFEQFNTVISPKHVLFYKPSNKSQLLLKQLKQDVEQYTSLQRFQSPTKFETIKLNFINQVNENPTPWFFSWFIQFHAKPLLEKLVSFESNIIKTKQAYLNGIESYVASCKKLLKTTILNNFFQLYQTNKDELLEICRQAKNPVLKEITWWFKKHFELLKKLFPVHIMTLESAATLTPNQRGLYDYVVIDEASQVFLERAIPILFRADKYIIAGDTKQLKPANFFQSRAEYDVDEEFEDGNIEAAVHSSSLLHFLKNRSRILTLLKFHYRSDSADLIAFTNNRIYDNELIFMNKANADQRVFIVHDVIDGIWKNNRNLQEARDVVQRLEQLTTTNDYKKSLGVICFNKNQADLIEYLIDKQNNPLLNEWRERQNDVGEYEGLFVKNIENVQGDERDIIIFSLGYDRSVNSYGPISKQGGENRLNVAITRAKQRIELFKTNRGEDYNGLSSSSLGSKLLVEYLLYCEAMAKNQGEKITFQAVKRKETKAKYELAVENDFFNQLQAIFGGEFEIKRNVNEGAYFFSFVFYFNNIPYLAIDFNIPIPTSRKQVMEGILYREQFLKKRQWNLINIWIDEWKLNPIGVISKIRSSLAVHQNQHEEI
What are the official names of this protein?
Uncharacterized ATP-dependent helicase MG140.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
Protein: GUAA_SHIB3
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMHMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLIEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: SYR_MYCMM
Sequence: MTPADLAELLKSTATAVLSEHALDTSALPQTVVVERPRNPEHGDYASNVALQLAKKVGANPRELAGWIAEALTKADGIASAEVAGPGFINLRLETSAQAKIVNAIIDAGSGFGHSELMAAHKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLSTQGADVVREYYFNDHGAQIDRFANSLIAAAKGEPTPDDGYAGTYINDIAARVLQKAPDALSLPDAQMHETFREIGVDLMFSHIKESLHEFGTDFDVYTHEDSMHSTGRVDQAVARLRETGNIYEKDGATWLRSSSFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRERGFDLCIYMLGADHHGYIARLKAAAAAFGEDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVITLDDLVEAIGVDAARYSLIRSSVDTPIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELGLIPDTDHLELLSHEKEGVLLRTLGDFPRMLKTAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEEPTQLHTARLALCQATRQVIANGLGILGVTAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFE2_MESAU
Sequence: MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSGSWGNSDQNSSSFDPSRTYSEGAHFSESHNSLPSSTFLGPGLGGKSSERSAYATFGRDTSVSALTQAGFLPGELGLSSPGPLSPSGVKSGSQYYPSYPSNPRRRAADSGLDTQSKKVRKVPPGLPSSVYPSSSGDSYGRDAAAYPSAKTPGSAYPSPFYVADGSLHPSAELWSPPSQAGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQERMSYQLHGSEVNGTLPAVSSFSAAPGTYGGASGHTPPVSGADSLMGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPTYDGGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFPGPVPLGGRHAGLVGGGHPEDGLTSGTSLLHTHASLPSQASSLPDLSQRPPDSYGGLGRAGAPAGASEIKREEKDDEESTSVADAEEDKKDLKAPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPPGHL
What is the function of this protein?
Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
What are the official names of this protein?
Transcription factor E2-alpha, Immunoglobulin-enhancer-binding factor E12/E47, Transcription factor 3, TCF-3, Transcription regulator Pan.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y255_ALIB4
Sequence: MSKEKGDIAEKKAISFLEKSNFEIVEKNFYAKKLGEIDIIAQRNKIYHFIEVKSANDYETAINNITSQKLSKIKRSVDFYIQKNNLNISYSIDVIIVVDDKIELLENITM
What are the official names of this protein?
UPF0102 protein Abu_0255.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SPEH_CLOBJ
Sequence: MKYSGYHLVIDLFGCNFDQLENTEYIIEMLKKLARALDTKIVAKAFHKFHPQGFSGALIISESHITIHTWPEDAYIGIDIFTCSKCFDPRKIVAYLKENLIFKKVEIKEILRGKID
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: MIAA_MOOTA
Sequence: MSTLSTKEPLAAIVGPTATGKSTIALKVAARLGAEIISVDSAQVYRGMDIGTAKLLPEERVGPDGRPIPHHLIDIVDPDEPFSVADYQKLARQTITAIIRRGHLPLLVGGTGLYYQAVVDPYRFTPEGGDPRVRQELEELAAKFGDAYLHEQLKRVDPEAAKRIHPHDRRRLVRALEVFKTTGQPISAALAWRRQQESPYHLAAVALSMPRPLLYRRIEARVDAMIAAGLIEEVSRLLARYDYRLPALQALGYKEIGAYLRKEIELEEAIAILKRNTRRLAKRQLTWFRRDRRLHWWEVDPDKIEEISAAIADFISRTIDINVE
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ACKA_SHEB5
Sequence: MSNNLVLVLNCGSSSLKFAVIDAQTGDDQISGLAECFGLEDSRIKWKINGEKHEAALGAFTAHREAVEYIVNKILAEQPELAAKIQAVGHRIVHGGEKFTRSVIIDESVIKGIEDCASLAPLHNPAHLIGIRAAIASFPKLPQVAVFDTAFHQSMPDRAYVYALPYKLYREHGIRRYGMHGTSHLFVSREAAKMLNKPIEETNVICAHLGNGASVTAIKGGKSVDTSMGLTPLEGLVMGTRCGDIDPSIIYHLVHQLGYTLEEVNNLMNKQSGLLGISELTNDCRGIEEGYADGHKGATLALEIFCYRLAKYIASYTVPLGRLDAVVFTGGIGENSDLIREKVLNMLEIFNFHVDSERNKAARFGKKGIITQDKGTIAMVIPTNEEWVIAEDSIKLINK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMP14_PIG
Sequence: MSPAPRPVRSLLLPLLTLASALASLSSAQSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSESGFPTKMPPQPRTTSKPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRKNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRRLPTDKIDAALFWMPNGKDYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix, such as collagen.  Activates progelatinase A.  Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development.  May be involved in actin cytoskeleton reorganization by cleaving PTK7.  Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2.  Involved in the formation of the fibrovascular tissues in association with pro-MMP2.  Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
What are the official names of this protein?
Matrix metalloproteinase-14, MMP-14, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.
Protein: SYGB_MOOTA
Sequence: MARDLIFEIGTEEIPARFMNPALEQMAAVASQLLQEYRLPCQKVATYGTPRRLALYLTALAENQEELVQEIKGPPVKAAFTADGQPTKAALGFARSMGVAVEELVTREYNGGQYVFAIKREQGRPAVTVLPELLLAVVNALSFPKPMRWGSLEIRFARPIRWLLALFGSEVIPVELAGLTASNQTYGHRFLAPGPHQVPTASAYFQVLEENYVLVDQHRRRQLIWEQITGLASREGGRVEKDPELLEEITYLVEYPTALAGHFDPEYLKLPQEVVITPMRDHQRYFPVWNAQGELLPRFITVHNGTADHLENISRGNERVLAARLADAAFFYQEDRQTPLAAKVPKLEEIVFQESLGTMLAKTRRLQRLAVNLVNTLDLPAELVPLVERTAELAKADLVTAMVYEFPELQGIMGSYYAAHDGERAEVCQGIRQHYWPRFAGDRLPDSLTGMVVGLADRLDTLVGCFGAGLIPTGSQDPYALRRQATGVVTIAVEFNLKFSLTASIAAAYEGYTAGGIQLARPLDVVQEQLVQFCRQRLEHLLEEKGYRYDVIQACLAAGSDDLAAAYHRTRDLSAFREEEGFAALQTAFTRAFNLARQAREKYHLRPEALQEKAEAELYRALMETRHQAEPRLRAGDYLAALKAMAALRGPIDAFFDNVLVMAPDMEVRNNRLALLQAIVNLVFQIADFSRLVP
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNU_DEIRA
Sequence: MTTLLPALDLAQLDALDARDPLAHKRAEFDLPGDIIYLDGNSLGALPRRVPARLSQVATEEWGHHLIRSWTRNAEAAQDWMALPDRVAAKLAPLLGAGAHEVAVGDSTSVNTFKALAAALRLSGRRVILSDADNFPTDLYVAQGLARLLGDVEVRTAPGDEMTQHFTDDVGVVLLTEVDYRTGRRLDMRAITAAAHARGIVTVWDLAHSAGAFAVDLGGAGADFAIGCGYKFLNGGPGAPAFLYVAERHLDRAEVVLSGWMGHADPFEMARAYAPAPGARRFVVGTPQVLSLSALDAALDVFGDVDLGALREKSLSLTDTFIRLMEPLAEQYPLELVTPLAHAERGSQVSYRHPHAQQVMAQLIECGIVGDFRTPDILRFGFTPLYLSHGDVGRAVAGIAAVLDELEGPA
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: SYC_YERPA
Sequence: MLKIFNTLSRQKEEFKPIHAGKVGMYVCGITIYDLCHIGHGRTFVAFDVVARYLRYLGYSLTYVRNVTDVDDKIIKRAIENNETCEQLTTRMLAEMHKDFDALNLERPDLEPRATHHIAEIIEMTERLIARGHAYVASNGDVMFAVDSDPDYGVLSRQDLDQLQAGARVEVADVKRNPMDFVLWKMSKPGEPRWESPWGPGRPGWHIECSAMNGKQLGAHFDIHGGGSDLMFPHHENEIAQSTCAHDGPYVNYWMHSGMVMIDKEKMSKSLNNFFTIRDVLAYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDANATPAGGAEFEARFRTAMDDDFNTPEAYSVLFDIAREVNRLKNEDMAAANGLAAELRKLAQVLGLLEQDPELFLQGGAQADDDEVAKIEALIKQRNDARSSKNWALADAARDQLNELGIVLEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_VARPS
Sequence: MKAIVQRVASARVDIAGQTVGAIGAGLLVLLCAERGDADAMADRMLAKLLKLRIFSDEAGKMNRSVQDIGGGLLVVSQFTLAADVSGGNRPSFTQAAAPDEGRRLYDYFVHRARAAHPLVATGEFGADMQVHLVNDGPVTIPLQMA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBL_HALS3
Sequence: MTRVVAQGTFDLIHPGHVHYLEDAAAMGDELHVILARRENVTHKDPPVLPNRQRRDVVAALDPVDHARIGHPEDIFAPIEAIDPDVIALGFDQHHDAAAIEAELADRGLDCAVERASPREARYDDEVLSSGDIADRVLAQRGDSDP
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.