Protein: NIPBL_CAEEL
Sequence: MDPNNLQNSLNGTGNPNFQPVQTNAGGFGHQMAQTGAAAAAAATGQYNPMLLQQQYLNFGFGMNYNNQLFDFQAQQQQQQQYLMQQQQQQQQLHHQQQQQHQNIAQPQAQHHQMNMFTQHQMLQLMQQQQQQQQQQPVQQIQRQQPIAQPIPQHTIPPSTSNQFQQQIQSAASSIFDSSVISSHQKLYEEQCRQIEKERKEQEERKRKQELEEQRKRNEELKRLRIAEEKRLLEEQQRLREQMERERLAEIKRLEEAARLEDERRIAADIEAQKQAMLQKMQAEQNKHIAEVERQRSELEERFARVSQPMTLVGTHFLPNFLDMIPFPYESMVDSTLPQVFDMERDSAILESCDPQMVATISNILNATNIDDIITRMDKLRPDDKETNDLFLDKLPPIIQAVVNYNTSALDVDSHNDMELLENEDVMMTEDITRTTAPSTSSSSYNNHHQNSIVMMTSSSVSMSEATQSSSVTMNHHDVDEEGPAPISIEKRRQMMSVGKAPKAGGGGGQNQRKKRDMVENLYDSLTDNFVPTDTGRRGRRRGRGSDDDEDELLQRDLKLIEEMEKGVKLPASVTGFTTTEEDVQHFFGSQKKRRKEDRIRKDRSPTPEDVIESRDAEWQERLRLKMEREKSRKADEESQNAWSLQALADNETFTRFCQTVDGVLEQGDSLDTELKMPKNKKRRSGGDHHHKGDENSDESDEEEEMDEIDPDLRIELYILEELRRGSARLRENHALQAVGADKLLKLVAMLDRNIRDAISADNQRLLVPCDDDVDVGDVLEKEICEERVKRASDAAVVALNIMSSHRMHKQVIIEDVIDRCVGLTRLLLIHLIYPASDSIYKSVNSKKKDRAPEEARRRKKAGVCTRDKFSEYIYERITEAIGLLAVLVKSESMTDTSVHNVASVALTPFFVANVGSLQITAMLLASNIFSRAEDSLRFSMITDLLSSLHRAPQFTQKNSNNGYSLPDGSWISTTTALFIQLVQSTIKIPKFKKHADEDELAKRSKKEEAMVKEGFLKASKVTNAFLNGFLAKCSQKGNKMDGEEDYRILFSNFLQELLSALYSPEWPAAEMILTALGSLLVKNFRSKSSDMTIRQASLDYLGNITAKLRKDQKEAIAGERRLDAVVKKSFLLLSDKGVEDYESVDISNLKQNDKLKVLETSLIDYLVITNSSDIIVYACNFYVGEWYKEVAEDLESARSKLKQTVDTNESEKDVKKAERKYEKIQYRGAEMKVFLSKILDKKEIKRRLEKSNKVKMLDSDAFWAVKFLAQSREFTHSFDTYLKHIVFGAGSETIVALRSKALKCLSSIIEADSSVLILEDVQQAVHTRMVDSHAQVRESAVELIGRFVLYDEEYVRKYYSQIAERILDTGVAVRKRVIRIMREICEKFPTFEMIPDMLARMIRRVTDEEGVKKLVFETFTTLWFQPVDTRIYTNAVATKVTTMCSVAQHCIKDAMSDYLEQLILHIVKNGQEGSGMSVAVKQIIDSLVDHILNLEQHKSSENVSEVELMRRKEQEEKYMAYLSTLAVFSKIRPLLLTSHVEVLLPYLTFSGAKTNAENQVTKEMIGMLERVIPLVPFPSNIVLDSIDENLCKVIMFNGMALVVSAVSCVASIYKKFKRGATKTIDVFSTYLKHLEVIKRNFDSNPRYDLDPKLFPILSRSIFTLGVLSRYFQFEEFVKEDPTEEKVEALKEKVFITLEFFSRYHKGGLRQKALTAMGHFCAQHSTYLTKRQLTNTYLEILNAANSPQQQQQRILVLQNLEMFLQCEEQKLAASHDKWDENKEAQNLKEMELSGSGLGSSVIQKYWKAVLESYVDADIQLRRAAVQVVWLTLNQGLVTPGASIPTLIAMTTDPVDVIRNRIDILLKEIDSKYSGMVQSKAMQGVRLSYKLHLKLRMLQQEKFVRGFRFCDFHLNTLPNALPEKTHDGMAVLSGLYQSLRTNRQQRRSFLQSMVKLFSEEFSHDKPQLMEYIFIADNLAMFPYQMIDEPLYVMRQIDQNIAQTGQSLLVQYKLQLRMQESEDEDIVFLDENMMSRLSQLGQIETFHQLFLDSQVPSLLLYVRTFLMQLYGFNETKVAEYQPSEAAKVYEKAVTRRNIHMFKPITALEALNFPFEWGSFQHTAFLAEKICSFRKMLLSLDQVEEVEVSNTITAANDDYDEEEDGGEDSRGPIMEQMEH
What is the function of this protein?
Plays an important role in the loading of the cohesin complex on to meiotic chromosomes (PubMed:21856158).  Forms a heterodimeric complex (also known as cohesin loading complex) with mau-2/SCC4 which mediates the loading of the cohesin complex onto chromatin (By similarity).  Plays an essential role in cell division during embryonic development (PubMed:15146185, PubMed:16802858).  Promotes normal chromosome organization during meiosis (PubMed:21856158).  Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during meiosis (PubMed:21856158).  Required for chromosome segregation during mitosis and meiosis (PubMed:16802858).  Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites (PubMed:21856158).
What are the official names of this protein?
Nipped-B-like protein scc-2, Prion-like-(Q/N-rich) domain-bearing protein 85, SCC2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SCC2/Nipped-B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to pachytene nuclei in germlines (PubMed:21856158). Localizes to the axial element of meiotic chromosomes in germlines (PubMed:21856158).