PharMolix/UniProtQA huggingface dataset:
Protein: TRIM5_ATEGE
Sequence: MASEILLNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESTLHQGERSCPLCRVSYQSENLRPNRHLANIAERLREVMLSPEEGQKVDRCARHGEKLLLFCQQHGNVICWLCERSQEHRGHSTFLVEEVAQKYQEKLQVALEMMRQKQQDAEKLEADVREEQASWKIQIENDKTNILAEFKQLRDILDCEESNELQNLEKEEENLLKTLAQSENDMVLQTQSMRVLIADLEHRLQGSVMELLQDVEGVIKRIKNVTLQKPKTFLNEKRRVFRAPDLKGMLQVFKELKEVQCYWAHVTLVPSHPSCTVISEDERQVRYQEQIHQPSVKVKYFCGVLGSPGFTSGKHYWEVDVSDKSAWILGVCVSLKCTANVPGIENYQPKNGYWVIGLQNANNYSAFQDAVPGTENYQPKNGNRRNKGLRNADNYSAFRDTFQPINDSWVTGLRNVDNYNAFQDAVKYSDFQDGSCSTPSAPLMVPLFMTICPKRVGVFLDCKACTVSFFNVTSNGCLIYKFSKCHFSYPVFPYFSPMICKLPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: LIPB_SYNE7
Sequence: MSARAAWLVQAGCLDYAQVWAWQRQLQDNRRNNPDRPDVLLLLEHPAVYTLGRGSSLAHLKFDPQHPPAPVYRIERGGEVTHHAPGQLVGYPILNLRHHRCDLHWYLRQLEAVLILVLANYGLTGERIEGLTGVWVEGKKLAAIGIQVSRWISLHGFALNVCPDLAGFEAIVPCGISDRAVGSLVEFCPDVRLEVVRSQVAGAFAQTFELDLQPCSLEQLQAEENLTAIAGDP
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_PROMS
Sequence: MSQEILEKVCSIVSEQLSVEAGEVKSDSNFQNDLGADSLDTVELVMALEEAFDIEIPDEAAEGIATVGDAVKFIEEKKG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC2_MOUSE
Sequence: MGSRFFLALFLVILMLGNEVQGNQEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLRGE
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: AES_SALA4
Sequence: MKPENKIPVLTRLSDEMKAVVNFQQPGLPPWPADGDIETQRQYYLLERRFWNADAPSMTTRTCAVPTPYGDVTTRLYSPQPTSQATLYYLHGGGFILGNLDTHDRIMRLLARYTGCTVIGIDYSLSPQARYPQAIEETVAVCSYFSQHADEYSLNVEKIGFAGDSAGAMLALASALWLRDKHIRCGNVIAILLWYGLYGLQDSVSRRLFGGAWDGLTREDLDMYEKAYLRNEDDRESPWYCLFNNDLTRDVPPCFIASAEFDPLIDDSRLLHQTLQAHQQPCEYKMYPGTLHAFLHYSRMMTIADDALQDGARFFMARMKTPR
What is the function of this protein?
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons).  Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate.  Negatively regulates MalT activity by antagonizing maltotriose binding.  Inhibits MelA galactosidase activity.
What are the official names of this protein?
Acetyl esterase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_PROM2
Sequence: MNKLRSSAITQGVQRSPNRSMLRAVGFNDEDFNKPIIGVANGYSTITPCNIGLNKLALKAEESIRRSGGMPQKFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDAVLAIGGCDKNMPGAMIAIARMNIPSIFIYGGTIKPGKLHGEDLTVVSAFEAVGQLTSGKINEKRLIEVEKNCIPGAGSCGGMFTANTMSAVIEVLGLSLPHSSTMAAEDLEKELSAEKSAEILVSAIKKNIRPLDLMTKKAFENAISVIMAVGGSTNAVLHILAIANTAGIDINIDDFERIRQKVPVICDLKPSGKFVTVDLHNAGGIPQVMKILLNAGLIHGECKNIEGKTITEYLQNIPDKPPSNQNVIRGIDYPLYKKGHLAILKGNLAKEGSVAKISGVKNPVLTGPAKIFESEEDCLKAILNNEIIAGDVVVVRNEGPVGGPGMREMLSPTSAIVGQGLGEKVALITDGRFSGGSYGLVVGHIAPEAAVGGNIALIKEGDLITVDAVKQLIEVDLSDEELEKRKNNWVKPKPKYKRGILSKYSKIVSTSSLGAVTDL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: DPH51_CANAL
Sequence: MLYLIGLGLSYESDITVRGLETVKKCKRVYLEAYTSILMAANQESLEKFYGREIILADRELVETGSDDILKDADKEDVAFLVVGDPFGATTHTDLVIRARELGIKVETIHNASVMNAVGACGLQLYQFGQTVSLVFFTDSWKPDSFYGKIMENRKIGLHTLLLLDIKVKEQSIENMARGRLIYEPPRYMDIATAAQQLLEIESIRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLHSLVMLGRQVHELELEYLYQFVDDKEKFKKFVEQDQEFFKPAPYVPPEDVDSE
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester.  The four successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine methyl ester synthase 1, Diphthamide biosynthesis methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_SHIDS
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAHSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: COAD_STRP1
Sequence: MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMNEKT
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT05_PONAB
Sequence: MATAVRAVGCLPVLCSGTAGHLLRRQHSLNTLPAASILAWKSVLSNGHLSSLGTRDTHPYASLSRALQTQCCISSPSHLMSQQYRPYSFFTKLTADELWKGALAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRYGFLWPGLNVPVMKNGTVQTIAQRSKEEQEKVEADVIQQREEWERKKKMKVKRERGWSGNSWGGLSLGPPDPGPSGETYEDFDTRILEVRNVFTMTAKEGRRKSIRVLVAVGNGKGAAGFAIGKATDRMDAFRKAKNRAVHHLYYIERYEDHTIFHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYAKVSGSTNMLSLTQGLFHGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASPRGALRKDPEPDEVPDIKLDWEDVKTAQGMKRCVWSNLKRAAT
What are the official names of this protein?
28S ribosomal protein S5, mitochondrial, MRP-S5, S5mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HBL1_GOSHI
Sequence: MATYEGKVFTEEQEALVVKSWTVMKKKTAELGLKFFLKIFEIAPSAKKLFSFLRDSNVPLEQNTKLKPHAMSVFVMTCESAVQLRKAGKVTVRESNLKKLGATHFKYGVVDEHFEVTKFALLETIKEAVPDMWSDEMKNAWGEAYDRLVAAIKIEMKACSQAA
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin 1, GOShi GLB1, Hb1.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: MEND_YERPB
Sequence: MSTSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGHLALGLAKASTEPVAVIVTSGTAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAIRQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQHGALHINCPFAEPLYGGDEQQYADWSASLGDWWQDCHPWLRQTCYPPSLYQPLAQQADWFFWRQKRGVVIAGRMGAEEGRQLTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQIVLQFGSSLTSKRLLQWQTACQPQEYWLVDSAPGRLDPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSESAQAQVIETLSGQFSEAAVAHQLAELLPDNGQLFVGNSLIVRLIDALGQLPAGYPVYSNRGASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQIFSLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLREHVHQCWLRGGTTLIEVQVPPSQGAETLQQLVQQVTLIPQVAP
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RECO_SALHS
Sequence: MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSNLKGALQPFTPLLLRYSGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLNCIQALAGTTGSPEPALRRFELALLGHLGYGVNFTHCAGSGERVDDTMTYRYREEKGFFASVVIDNNTFTGRHLKALEAREFPDVDTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTKKD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: CRCB_ECOLC
Sequence: MLQLLLAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLTANLIGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTALAFWLFSASTAH
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECO_STRS2
Sequence: MERIETRGLVLYNRNFREDDKLVKIFTEKAGKRMFFVKHASKSKLVASIQPLTYADFIVKINDDGLSYIEDFHQVQPFKNINGDIFKLSYATYILALADAALQDKVYDPALFAFLVKTLDLMESGLDYEVLTNIFEIQLLGRFGISLNFHECAFCHRVGLPFDYSYKYSGVLCPQHYQQDERRAYLDPNVPYLLDQFQAISFDELETISIKPEMKRKLRFFIDQLYEEYVGIHLKSKKFIDDLSSWGQIMKPRTENEETE
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MLTF_SHIB3
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLCNLTAEQLTVAPGHVVVNDLQTLKETKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: CO9A2_CHICK
Sequence: MAHRSPALCLLLLHAACLCLAQLRGPPGEPGPRGPPGPPGVPGADGIDGDKGSPGAPGSPGAKGEPGAPGPDGPPGKPGLDGLTGAKGSRGPWGGQGLKGQPGLPGPPGLPGPSLPGPPGLPGQVGLPGEIGVPGPKGDPGPDGPRGPPGPPGKPGPPGHIQGVEGSADFLCPTNCPPGPKGPQGLQGLKGHRGRPGALGEPGQQGKQGPKGDVGVSGEQGVPGPPGPQGQRGYPGMAGPKGETGPAGYKGMVGTIGAAGRPGREGPKGPPGDPGEKGELGGRGIRGPQGDIGPKGDMGLPGIDGKDGTPGIPGVKGTAGQPGRPGPPGHRGQAGLPGQPGSKGGPGDKGEVGARGQQGITGTPGLDGEPGPPGDAGTAGVPGLKGDRGERGPVGAPGEAGQSGPKGEQGPPGIPGPQGLPGVKGDKGSPGKTGPKGSTGDPGVHGLAGVKGEKGESGEPGPKGQQGIQGELGFPGPSGDAGSPGVRGYPGPPGPRGLLGERGVPGMPGQRGVAGRDAGDQHIIDVVLKMMQEQLAEVAVSAKRAALGGVGAMGPPGPPGPPGPPGEQGLHGPMGPRGVPGLLGAAGQIGNIGPKGKRGEKGERGDTGRGHPGMPGPPGIPGLPGIPGHALAGKDGERGPPGVPGDAGRPGSPGPAGLPGFCEPAACLGALPTPRHG
What is the function of this protein?
Structural component of hyaline cartilage and vitreous of the eye.
What are the official names of this protein?
Collagen alpha-2(IX) chain.
What is the protein family that this protein belongs to?
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TYLH1_STRFR
Sequence: MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFSPPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRELRPSVEQIVTGLLDDLTARGDEADLLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVAW
What is the function of this protein?
Involved in the biosynthesis of the complex macrolide antibiotic tylosin.  Catalyzes the hydroxylation of 20-oxo-5-O-beta-mycaminosyltylactone at the C-23 position to yield 5-O-beta-mycaminosyltylonolide.
What are the official names of this protein?
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase, Cytochrome P-450 monooxygenase TylH1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: DCD_LEGPL
Sequence: MSIKSDRWIEKMALEHGMISPFQAGQVRENQNGRIISYGVSSYGYDVRCSNEFKIFTNINSAIVDPKAFDENSFVDVQSDVCIIPPNSFALARTVEYFRIPRNILTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTTLPAKIYAYEGVAQMLFLEANEVCAVSYRDRNGKYQGQTGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TYSY_CORA7
Sequence: MATMIETPYEDLLRRVLEEGAPKGDRTGTGTLSLFGAQLRYNLAESFPLLTTKKVYFHGVIGELLWFLRGDSNVKWLQENKVRIWNEWADEDGELGPVYGVQWRSWPTPDGQHIDQIQVALDTLKNNPDSRRNLVSAWNVSELDKMALMPCHLLFQLYVADGKLSMQVYQRSADMFLGVPFNLASYAALTHMFAQQAGLEVGELIWTGGDCHIYNDHIEQVKEQLSRQPREYPQLKLHKAESLFDYDFDDFEVIGYDPHPTIKAQVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_CROS8
Sequence: MKRAFIMVLDSFGIGATEDAERFGDAGSDTLGHIAEACAKGEADIGRKGPLHLPNLTKLGLAKAHEGATGFIPAGMDGNAEITGAYAWAHELSSGKDTPSGHWEIAGVPVLFDWGYFTDEKNSFPQELLDKLVERANLPGYLGNCHSSGTVILDELGEEHMKTGKPIFYTSADSVFQIACHEETFGLDRLYELCEIAREELTEGGYNIGRVIARPFVGDKAGNFQRTGNRHDLAVEPPSPVVLKKLVDEKGGHVVSVGKIADIYANMGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELLELVGEDDIIIFTADHGCDPTWKGTDHTREHIPVLVYGPKVKPGSLGHRDTFADIGQTVAKYFGLSDMEYGKALF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5320_RICCK
Sequence: MKKLLLIAATSATMLSSTLSFADGMDNEWYLRIGAGAAMFNKEKDEATSVKLKSNMTVSVDLGIGYYFSKNFRTDLTLGTIIGGKLKKSGTATNVPFSGTNVSVSYKPTITRLLINGYVDLTNFNIFDVFAGAGVGPALVKEKITYNGITGLASTTKNRTNISYKLTLGTSAQIADDVKVELAYSWINDGKAKSKNVVYQGQKVQIGGMRYQSHNLTASIRFDI
What are the official names of this protein?
Putative adhesin A1E_05320.
Protein: LTD_ORYSI
Sequence: MASIPCTFQLSARASSASAAAAARRSPRAAARLGWLRPSRLSAVVPASESGRVGPTCFFKFGNKDAEGAGIYGSQGRDDFDRDDVEQYFNYMGMLAVEGTYDKMEALLNQDIHPVDILLMLAASEGDKPKLEELLRAGAKYDVKDVDGRTALDRAADDTREFILGFAATLAA
What is the function of this protein?
Involved in the import of light-harvesting complex proteins (LHCP) and subsequent routing of these proteins to the chloroplast signal recognition particle (SRP) pathway.
What are the official names of this protein?
Protein LHCP TRANSLOCATION DEFECT.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GAK1B_HUMAN
Sequence: MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASLQHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPANIRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPWRLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSSRSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAEFIQDGRPCPIILWDASLSSASNDTHSSVKLTWGTYQQLLKQKCWQNGRVPKPESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSAALAHIIQRKHDPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLLQSLFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE
What are the official names of this protein?
Golgi-associated kinase 1B, Expressed in nerve and epithelium during development, Protein FAM198B.
What is the protein family that this protein belongs to?
Belongs to the GASK family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SAT_BACC2
Sequence: MSTVNELVNRIDETYEVSQIEKEIKLDNIALSDLELLATGGYSPLTGFLGKEDYDSVVETLRLANGSVWSIPITLPVTEEVAESLKTGEEVKLVNNGNIYGVIQIEDIFIPDKEKEALLVYKTTDEVHPGVKKLYERPNVYVGGTIILTKRFENNQFPSYRLDPIETREEFKKRGWKTVVGFQTRNPVHRAHEYIQKSALEIVDGLFLNPLVGETKSDDIPADVRMESYEVLLQNYYPKNRVFLSVFPAAMRYAGPREAIFHALVRKNFGCTHFIVGRDHAGVGDYYGTYEAQEIFTNFTIEELGITPLFFEHSFYCTKCEAMASTKTCPHGKEDHVILSGTKVRELLRNGEIPPSTFSRKEVVEVLIKGLKKEVVTE
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: MUP3_YEAST
Sequence: MEPLLFNSGKANPSQDVFIDVEVGDITTKYGSTNTGSFSSMDTVEAQAIKAETARFMEVPQGRHLGVFSTVVLFVSRIMGSGIFAVPSVILLNTGGNKLIYFAIWVFSAAIAFAGLYLFLEFGSWIPKSGGRKNFLERSFERPRLLISVVFSCYSVLTGYALTGSIVFGKYVLSAFGVTDDSWSKYVSISFIIFAVLIHGVSVRHGVFIQNALGGLKLIMIVLMCFAGLYTLFFYKSTGQVAWDLPVTQVEKDSLLSVSSIATAFISSFFCFSGWDTVHTVTSEIKNPVKTLKVSGPLSLIICFVCYTMMNVAYLKVLTYEEIVSAGPLVGSVLFTKLFGPRVGGKFIAFSIAISAASNILVVIYSISRVNQEIFKEGYLPFSIHMSKNWPFDAPLPSISLCGFITIAWILILPKEGESFNYLVSMDGYGNQFFLLLVAIGLFIWRFKHKNEVPEIRASTFGVLAIITLSLYMLMAPFFADPSLNRVGFLPPYQIMSLLVIVACFFFWLVKFVLLPKFFHYKLLPKITYLHDGLIVTEWVKKPCLC
What is the function of this protein?
Very low affinity permease for methionine.
What are the official names of this protein?
Low-affinity methionine permease.
What is the protein family that this protein belongs to?
To yeast high affinity methionine permease (MUP1).
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MURG_ORITB
Sequence: MKTIFLVGGGTGGHLFPAIALGEELQERGYNVYLITDTRCEKYLLNFNYSFKIHIMNMVSISNTGIKKLYAYIRILAACITGFKLVYSNSPSLIVAFGGYTIAPIIINGILFRIPFILHEQNSVLGLANRLFLRYAKAITVTFANTLNLNNRYKHKVIVTGTPVRKALRFTPKRNFNSKNFQLLVIGGSQGTKIFSTLVPNAIKLLVNCDHDFKITIVHQAVAKDINYVKAMYTELNIEHEVSDFFYNIADKYKNSHLAICRAGASTISEIISLCQPAILVPYPVSAQNHQLFNAKAIADNKAGWCIEQSTITPHILFEKIFTLMQSPTLLASTELKLREMKINAENLLANVVDKFIVT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BEST9_CAEEL
Sequence: MTISYSGNFFRLLLRWKGSIWRSVWRELFLFLFLFYFIRFSAPHFFNYTDPTDSKGYRKIFKVMCNEFHEYTKMIPLTFLLGFYVSNVVSRWWRQFETLRWPEDFLSILCLLLPSKESRPARHQIARYLNLTSALAWRDVSTKIRLRFPSLRNIIDAGLLTEKEYEKLQDINEPSPGIRWLTPLHWVQQLIDAEITAGRGSVNYVSVATNELKAYRISFRRLYCHDWVCVPLVYTQVAALATYSYFFFCLFGRQDLNHDDFYSLDAFFPLFTVVQFLFFVGWFKVGQDLMRPFGLDDDDFELSYILDRNIVTSFTIVDSLQDDDPPKFEEDVFWKHHNEQQQMHQSMFLPRVPTSLKWGRIDLSRNAHKHPPKLHTYLEMKNQDPEEYKNRKNNKFIAW
What is the function of this protein?
Forms chloride channels.
What are the official names of this protein?
Bestrophin homolog 9.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.