PharMolix/UniProtQA huggingface dataset:
Protein: TAAR1_HUMAN
Sequence: MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
What is the function of this protein?
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR.  Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin.  Trace amines are biogenic amines present in very low levels in mammalian tissues.  Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.  Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.  The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
What are the official names of this protein?
Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRFR1_XENLA
Sequence: MLLAKTPCLLLVQVIAAGISFALTSLQDQCETLQHNSNFTGLACNASIDMIGTCWPSTAAGQMVARPCPEYFHGVQYNTTGNVYRECHLNGSWAGRGDYAQCQEILKQEKKTKVHYHIAIVINFLGHSISLCALLVAFILFLRLRSIRCLRNIIHWNLITAFILRNVTWFVMQLTLSHEAHDSNVVWCRLVTIAHNYFYVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKKAGVYTDFIYQGPVILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVTPGEDEISRIVFIYFNSFLQSFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHSIRARVARAMSIPTSPTRISFHSIKQSSAI
What is the function of this protein?
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin).  Has high affinity for CRH and UCN.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase.  Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
What are the official names of this protein?
Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
Protein: NIFH_METVO
Sequence: MRKFCIYGKGGIGKSTNVGNMAAALAEDGKKVLVVGCDPKADSTRTLMHGKINTVLDTFRDKGPEYMKIEDIVYEGFNGVYCVESGGPEPGVGCAGRGVITAVDMLDRLGVYDQLKPDVVIYDILGDVVCGGFAMPLQKKLAEDVYIVTTCDPMAIYAANNICKGIKRYGNRGKIALGGIIYNGRSVVDEPEIIDKFVEGINSQVMGKVPMSNIITKAELRKQTTIEYAPDSEIANKFRELANSIYENKKTTIPTPLSEQGLDELTESIEELVRRKYE
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: TYSY_MARN8
Sequence: MKAYLDLMQDVVDNGFDKGDRTGVGTRSVFGRQMRFNLQDGFPLVTTKKVHLRSIIYELLWFLKGSTDNTWLAERKVSIWNEWALENGDLGPIYGKQWRSWQCHDGRVIDQISEVIEQIRTKPNSRRLIVSAWNPAELPDESISPQDNVREGRMALAPCHCLFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMIAQQCDLDVGEFVHTFGDCHLYRNHLTDDIVFEQLRREPRALPKLVIKRKPESIFGYELEDFEFEGYDPSPVIKAPIAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMAP2_HUMAN
Sequence: MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDINAFRKEKDDKWKRGSEPVPEKKLEPVVFEKVKMPQKKEDPQLPRKSSPKSTAPVMDLLGLDAPVACSIANSKTSNTLEKDLDLLASVPSPSSSGSRKVVGSMPTAGSAGSVPENLNLFPEPGSKSEEIGKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQAGYMAGMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMSGGNGQAANQTLSPQMWK
What is the function of this protein?
GTPase activating protein that acts on ARF1.  Can also activate ARF6 (in vitro).  May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).
What are the official names of this protein?
Stromal membrane-associated protein 2, Stromal membrane-associated protein 1-like.
What are the subcellular locations of this protein?
Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures.
Protein: ACDE1_METTE
Sequence: MVDTTKNTKLFTSYGVTTSKAINPDMAAKMISKAKRPLFVVGTGVLRPEILDRAVKIAKKANLPIAATGSSLNGFLDKDVDAKYINVHQLGFYLTDPAWPGLDGKGNYDTIIILEFKKYYINQVLSGTKNFSKVKSISIGKDYIQNATMSFGNISREEHFAALDELIDLL
What is the function of this protein?
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.  The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit epsilon 1, ACDS complex subunit epsilon 1, ACDS complex carbon monoxide dehydrogenase subunit epsilon 1, ACDS CODH subunit epsilon 1.
What is the protein family that this protein belongs to?
Belongs to the CdhB family.
Protein: COPB3_ECOLX
Sequence: MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRLDILK
What is the function of this protein?
This protein is involved in the determination of copy number in gene replication.  It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA.
What are the official names of this protein?
Replication regulatory protein repA2, Protein CopB.
Protein: OMPF_PROMI
Sequence: MRVIIMMKRNILAVVIPALMFAGAANAAEMYNKDGNKVDIYGKVDVRHYFADADTKGDHESGDASRARIGFKGETQINKDLTGFGRFEYEVKTNTTEGENKAKTRLAYAGLKFADFGSLDYGRNYGVIYDTNAWTDVLPLWGGDSMAQTDVYMTSRTTGVLTYRNTDMFGYVDGLSFALQYQGKNNENTNNKRKDNAEANGDGFGFSTAYNLGWGVTLGGGYSSSARTNWQEHKSDATGKRAEAWNVGGKFEANNVYLAAMYGETRNMNYYGDGAIANKTQNIELTAQYDFADLGIKPSLGYVQSKGKDLNNGVGGLKDNNHDLVKYISVGSFYKFNKNMTAVVDYKINLLDEDDFTKANGVATDNVVGLGLTYQF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane porin F, Porin OmpF.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
Protein: SYFB_PHATC
Sequence: MQISLKWIKELIDIENVDLDDLIEKLTLGGFEVEEILELEINNEKQIALEISSTANRSDSLSIQGISVEIASLFNKQPKVCKYFNSSLNWQQKIKNLTTIRTSKTECLMFTAVILEGLEDLTVPKWIQNKLVSSGIMPLNNLVDFQNYILLETGYPFAFYDLDKVYSKVRTPTFSLSIEKAENGSEFFASNQINYKLDNSIFLVQANNIPISIAGIIENDEIICHSKTSSLLIEGSIFSASKIRQQSRKLAIRTDRSARYEKSLKSTYLIEALYRLISLLRISNPSLVYKFHSSNKVLEKVLKPIVLNYKTIVEILGPIKKRTNEHLIYISPETVTDYLKRLNFKFLFDSSTLNWEVTIPSIRSDDITREIDLIEEVGRLHGFNNFLTMLPQIKSVGRADFSYQTRKKITSYLLNMGLTELIHYSLVSNETFLKNEIKLVNPLLSDCSTLRVSLLPSLLMTIQENLKQGNSILEGFEYGHVFSGNIETTLTEIEYVGGIFGGTKIKSSWFEKGQSLKWFEAKGKIEKLFQQLNLGIHWRINSQTYTKKFLHPYRSAEIFLSSGKNIGVFGQLHPLLANKLGLSSEIYLFELNLELIQQSLQQNKLTIYSQYSVYPKIVKDLSFIIKKNIKFDELEKIIYANGTEFLSQINLLDDYKGEFIPEKHTSLCLQLTFQSNKKTLENKEIDRIVKNLKRVLELKVQAILRE
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, chloroplastic, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YBEY_ACIBT
Sequence: MKISLSLQQDFQSPELELKRAQLKKIIETTLRHVGYKEDCEIGIACVDLEESHQLNLQYREKDKPTNVLSFPSDIPEEVLPMLDALPLGDLVICIPVVLQEALEQKKTAQNHFAHLLVHGVLHLLGYDHETSDEDAEEMEGLEIEILAKLNIANPYQE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJLA_COXBU
Sequence: MNWIGKLIGMMLGFILAGPIGLIIGLFIGHVVFDQGRFRQWFQTTASARSQPSKIQEVFFNTTFRVMGFVAKADGRVSENEIRQARQVMQQMNLDDSMKREAIRLFTEGKQPNFNLDESLNELRQACVFQPALLRVFLEIQIQMASADGQGLSGQKRQVLQTICRRLEVFGFDYNQFEQRFRAEQNYQRYQQRATQDPRAYLNDAYKVLGLTSAATDSEIKKSYRRLMSQHHPDKLMAKGLPPEMMKMATQKTQQIKKAYEQIRKVRSMV
What is the function of this protein?
Regulatory DnaK co-chaperone.  Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway.  The colanic acid capsule may help the bacterium survive conditions outside the host.
What are the official names of this protein?
Co-chaperone protein DjlA, Mucoidy activation protein MucZ.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type III membrane protein.
Protein: LPIAT_CAEEL
Sequence: MRIPCLLRPLLGWFFGLCILFSALFGNYIITLFLGLPILGRHKQWRNLMDRAISYWMTIPMGLLEFLMGVRIRVSGDEIEFGSPAMIVMNHRTRLDWMYMWCALYQINPWLITSNKISLKAQLKKLPGAGFGMAAAQFVFLERNAEVDKRSFDDAIDYFKNIDKKYQILLFPEGTDKSEWTTLKSREFAKKNGLRHLDYVLYPRTTGFLHLLNKMREQEYVEYIYDITIAYPYNIVQSEIDLVLKGASPREVHFHIRKIPISQVPLNEQDASRWLTDRWTIKEQLLHDFYSEEQPINRQFPVERGDGVWRSWKEPRRHFYVKLTSLMFWTLVISFCSYHIFFVRTLQLGFLYFFVISFYLSWRYGGIDKYIIFKWQESRKSLQKSPSSSSI
What is the function of this protein?
Acyltransferase required for the fatty acid remodeling of phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI).  Mediates the conversion of lysophosphatidylinositol (2-acylglycerophosphatidylinositol or LPI) into PI (LPIAT activity).  Has preference for saturated and mono-unsaturated fatty acids as acyl donors and sn-2-acyl lysoPI (2-acyl-sn-glycero-3-phospho-D-myo-inositol) as acyl acceptor.  Contributes to the asymmetric cell division of epithelial cells.  Asymmetric cell division is the fundamental mechanism by which multicellular organisms generate cell diversity.
What are the official names of this protein?
Lysophosphatidylinositol acyltransferase 10, ACL-10, sn-2 acyl LPIAT, 2-acylglycerol 3-phosphate O-acyltransferase 10, AGPAT 10, PlsC domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: P2RX1_MOUSE
Sequence: MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSGLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIMTPQQAQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKILHPLCPVFSLGYVVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGERDPAATSSTLGLQENMRTS
What is the function of this protein?
Ligand-gated ion channel with relatively high calcium permeability.  Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle.  Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).
What are the official names of this protein?
P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the P2X receptor family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ASIP_VULVU
Sequence: MNIFRLLLATLLVSLCFLTAYSHLAEEKPKDDRSLRSNSSVNLLDFPSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVARPRPPPPNPCVATRNSCKSPAPACCDPCASCQCRFFRSACTCRVLSPSC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: RL23_HALSA
Sequence: MSSIIDYPLVTEKAMDEMDFQNKLQFIVDIDAAKPEIRDVVESEYDVTVVDVNTQITPEAEKKATVKLSAEDDAQDVASRIGVF
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: GATA_MAIZE
Sequence: MPPPLQAHRLLISHRRLPTPARRRFTAASSVQSAPATTLAPGPATSSILSIRESLLSGERTAADITSEYLSRLRRTEPTLRSFIHVADAAAEREAEELDRRIASGEKDAVGPLAGVLVGVKDNLCTANMPSTGGSRILDGYRPAYDATAVRRLREAGAIVLGKTNLDEFGMGSTTEGSAFQVTTNPWDDSRVPGGSSGGSAAAVSARQCVVSLGSDTGGSVRQPASFCGVVGLKPTYGRVSRFGLMAYASSLDVVGCFGSSVFDTATILSVVAGHDKMDATSSSQVVPEYASELVSLDLLESKPLNGVRIGIIQETLGEGVASGVVSSIKGAASHLEQLGSVVEEVSLPSFSLGLPAYYILASSEASSNLSRYDGIRYGGQVSADDLNELYGESRANGFGHEVKMRILMGTYALSAGYYDAYYKRAQQVRTLVKQSFKDALERYDILISPAAPSAAYKIGEKINDPLAMYAGDIMTVNVNLAGLPALVVPCGFVEGGAAGLPVGLQMMGSPFCEGNLLRVGHIFEQTLQNLSFVPPLLAEGQL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial, Glu-AdT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Plastid, chloroplast stroma.
Protein: STY46_ARATH
Sequence: MVMEDNESCASRVIFDALPTSQATMDRRERIKMEVFDEVLRRLRQSDIEDAHLPGFEDDLWNHFNRLPARYALDVNVERAEDVLMHKRLLHSAYDPQNRPAIEVHLVQVQPAGISADLDSTSNDAGHSSPTRKSIHPPPAFGSSPNLEALALAASLSQDEDADNSVHNNSLYSRPLHEITFSTEDKPKLLFQLTALLAELGLNIQEAHAFSTTDGYSLDVFVVDGWPYEETERLRISLEKEAAKIELQSQSWPMQQSFSPEKENGQTGARTHVPIPNDGTDVWEINLKHLKFGHKIASGSYGDLYKGTYCSQEVAIKVLKPERLDSDLEKEFAQEVFIMRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPTLFKVAIDICKGMSYLHQNNIIHRDLKAANLLMDENEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLTGKLPYEYMTPLQAAVGVVQKGLRPTIPKNTHPKLAELLERLWEHDSTQRPDFSEIIEQLQEIAKEVGEEGEEKKKSSTGLGGGIFAALRRSTTHH
What is the function of this protein?
Serine/threonine protein kinase that specifically phosphorylates chloroplast precursor proteins in the cytosol within the cleavable presequences (transit peptides).  May be part of a cytosolic regulatory network involved in chloroplast protein import.  Does not phosphorylate mitochondrion precursor proteins.  Specific for ATP and does not utilize other NTPs (PubMed:17090544, PubMed:16429265).  Plays a role in chloroplast biogenesis and differentiation in cotyledons, possibly through phosphorylation of chloroplast preproteins (PubMed:21799034).
What are the official names of this protein?
Serine/threonine-protein kinase STY46, Serine/threonine/tyrosine-protein kinase 46.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: JASON_ARATH
Sequence: MRRLLMNRNLSPLCRSVLRFIDLSVCRAMACFLDCFRARDNRSTSNLVSHSSLANSRKAQDSQNDLSALFLSEEKSASSPCLDKERFDLDSIHIDKGLRDEARFLKACGTIPETPIEIRKASQKLSPQHSGSSHFHSWISSSSSMGSRLAESSTPMKACEEVGRPSFTSEQTASSCVIDVRDNARISSASSDGTEVESVGTAIKGELDRTARPTFTAGKNKSVRFECDLDQSNSSNSSENGSSRKPEMGGKICFTVSSPNPTPLKLSDEMQTPGTIYPANMESGGRGRPRIRSQFVHSVSNIMENASLYKVYKDSHEGLDYEEQIEAETPSSETYGEKVEESSDEKLSKFEASFSPWLNQINENIAALNERTPGVGVITPGDRPIIGLVAAQWIENEQTEISPKMWDGNGIPNSTTKYKEDQKVSWHATPFEVRLEKALSEEGGQSLFPQRKLEVMMEEVEGDTDISQLHHSVQPNSVVSF
What is the function of this protein?
Required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores.  Acts as positive regulator of PS1 in male sporogenesis.  Not involved in female meiosis.
What are the official names of this protein?
Protein JASON.
Protein: RGLT_EMENI
Sequence: MQYEAYQWGQSHPTSTSGSMLQDTPTAASQPVKRHAACDECRKRKLKCSGEISGCSRCIKQSLSCHYSVQKQMGRPPKKRLREDNDDISLLNIPDNDPWANSQIAHVPDFGAAIADVSEEPQILSSTHLSPYSFPYRLSTDEDHRHTWQLAPNESMSSIPATTTPWPDFSSVSAAAPKPFIMPPGLTPPIMPSTDSSPDQECSCLSYLYLCLSHLSSLKPFPISQHTICSLYISAKTAQSVIRCQSCPNRFDTGLQNVMFTGTLLNVIADSWLRVSRAEACELGNQVAPPAYAAKMNRSPDLRGAWNDYLRQLVRFSVIRGPMDIDAQTPCAQQAPSVLDLVEEMEARQRRWHESPDSHPLPPDQRLNIPSDQNCLNRDEQDLLCIRVAKSARNVIAKFGFQSDEYPESVPSLSPDSSISP
What is the function of this protein?
Transcription factor that is important for oxidative stress resistance and essential for gliotoxin (GT) self-protection through the regulation of a gene encoding a putative gliT homolog, even if E. nidulans does not produce gliotoxin itself.
What are the official names of this protein?
Transcription factor rglT.
What are the subcellular locations of this protein?
Nucleus.
Protein: AR6P6_BOVIN
Sequence: MSFVESGRRSAPLRRRPGTPVPFARPAYSVFSQGDSWGEGEVEEEEGCDQVARDLRAEFSAGSSSKLRKDPVLQPDGDGSPVLPDKRNGIFSADAGGKALARRWPVQVLSILCSLLFAILLACLLAITYLIVKELHAENLKNEDDVNTGLLGFWSLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKMTGHSFHMGYSMAILNGIVAALTVAWCLM
What are the official names of this protein?
ADP-ribosylation factor-like protein 6-interacting protein 6, ARL-6-interacting protein 6, Aip-6.
What is the protein family that this protein belongs to?
Belongs to the ARL6IP6 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein.
Protein: COBQ_VARPS
Sequence: MTTRCVMVLGTTSGAGKSWLTAALCRWYARQGLKVAPFKAQNMSNNARVVGGGEIGSAQYFQALAARAVPDVRMNPLLLKPERDTHSQVVLMGQVSAELTAMPWRGRSERVWPQIAQALDALRAENDVVVIEGAGSPAEINLMASDIVNLRVARHADARCLLVTDIDRGGAFAHLYGTWALMPESDRALLRGFVLNKFRGDASLLAPAPQQLQALTGIATVATLPMWREHGLPEEDGVFDDRSHASGAVTRTVAVVAYPRISNLDEFQPLKNVPGVRLAWARTPAELAGADWIVLPGSKHTSGDLAWLRAQGLDRAIAAHAARGGAVLGVCGGLQMLGEALVDPHGIDGNAPGLGLLPLVTVFEREKTVRHRAAVFGQLGGAWASLSNVPVAGYEIHHGQTAIHPQMAQDGHAVMPEGLAWQNARGNVLGLYLHGLFEDAAALHALFGAAAPTLDATFDGLADFIDNHFEAGVLQGLIA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: TRUB_CORGB
Sequence: MNAPAPKPGLVIVDKPAGMTSHDVVSKLRRAFSTRKVGHAGTLDPMATGVLVVGIERGTRFLAHMVASTKAYDATIRLGAATSTDDAEGEVISTTDASGLDHRAILAEIANLTGDIMQKPTKVSAIKIDGKRAHERVRDGEEVDIPARPVTVSVFDVLDYRVDSEFYDLDVRVHCSSGTYIRALARDLGNALQVGGHLTALRRTEVGPFTLNDATPLSKLQENPELSLNLDQALTRSYPVLDITEDEGVDLSMGKWLEPRGLKGVHAAVTPSGKAVALIEEKGKRLATVFVAHPNTL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MSPD1_MOUSE
Sequence: MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVIATLLPSAKEQQKEEEEKRIKEHLTESVFFEQSCQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDMESLVPLYLHLSVNQKLVAAYILGLITMAILRT
What is the function of this protein?
Plays a role in differentiation and/or proliferation of mesenchymal stem cells (PubMed:21792907, PubMed:26175344).  Proposed to be involved in epithelial-to-mesenchymal transition (EMT) (PubMed:21792907).  However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation (PubMed:26175344).
What are the official names of this protein?
Motile sperm domain-containing protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RUVB_PROMS
Sequence: MAIISSNIGDNDFSFRKKELRLVDSKNIPEEKRNNNLNLARPLNLKEFIGQEQLKSSLRVAIDASIIRKEPLEHTLLYGQPGLGKTTLAFLIAHELNTKCRIATAPAIERPRDIVGLLLGLKEGEVLFIDEIHRLNRLTEELLYSAMEDFRLDLTMGANRGARCRTINLPRFTLIGATTKLASISAPLRDRFGISQKIEFYTCDELKQIIVNFSRLINLNLEDEASYDLAKISRGTPRIALRLLRRVRDYAQVVMKTNTISVNLIKKALNSYQIDEKGLDSLDRHYLSFLNQNNNIPIGLDSIASGLGDDSSMLEFVVEPYLIKIGFLTRTPRGRLLTALGKKYIDSKDDNF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.