PharMolix/UniProtQA huggingface dataset:
Protein: CELF4_MOUSE
Sequence: MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing.  Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.  Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.  Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs.  Activates the splicing of MAPT/Tau exon 10.  Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity).
What are the official names of this protein?
CUGBP Elav-like family member 4, CELF-4, Bruno-like protein 4, CUG-BP- and ETR-3-like factor 4, RNA-binding protein BRUNOL-4.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RS12_THEKO
Sequence: MAGKKAPYGEFAGRKLKLKRKKFRWSDIRYKRRVLRLKEKSDPLEGAPQARGIVLEKIAVEAKQPNSAMRKAVRVQLIKNGKVVTAFTPGDGAINHIDEHDEVIIEGIGGPKGGSMGDIPGIRYKVVKVNRVSLKELVKGRKEKPRR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DNLI_AERPE
Sequence: MPFKPVAEAFASMERITSRTQLTLLLTRLFKSTPPGAIGIVVYLIQGKLGPDWKGLPELGVGEKLLVKAIALAYKATEERVERLYKSVGDLGSVAERLSREYRSRAARAVTLEAFMAGGGEALTVRRVYNTLYRIAMAQGEGSRDIKLRLLAGLLADAEPVEAKYIVRFVEGRLRVGVGDATVLDALAMAFGGGAHARPVIERAYNLRADLGYIAEVVAREGVDALRGVKPQVGVPIRPMLAERGRDPAEILRKVGGRAVVEYKYDGERAQIHKKDGEVYIYSRRLENITRMFPDVVEMARKGLKAGEAIVEGEIVAVDPDNYEIQPFQVLMQRKRKHDIHRVMREVPVAVFLFDALYVDGEDLTSKPLPERRRRLKEIVVETPLWRLAESIETSDPEELWTFFLKAIEEGAEGVMVKAVHRDSVYTAGVRGWLWVKLKRDYKSEMMDTVDLVVVGAFYGRGKRGGKLSSLLMAAYDPDRDVFPTVCKVATGFTDEELDRMNEMLKKHIIPRKHPRVESRIEPDVWVEPALVAEILGAELTLSPMHTCCLNTVRPGVGISIRFPRFIRWRDDKSPEDATTTHELLEMYKRQLRRVEEPAEQV
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.  Can also use ADP, but not NAD(+).
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP/ADP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: RL21_HELAH
Sequence: MSYAIFKHGGKQYKVVEGDIVLLDKMNKEPKALVELVEVLAVSKEGKLSCGKPFVNGAKIEVEVINEGRAKKVITFKKRRRKDSKTKRGFRRDFTRVRITKIVA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: PLIGA_CRODU
Sequence: MKYLHTICLLFIFVARGNSRSCDFCHNIGKDCDGYEEECSSPEDVCGKVLLEISSASLSVRTVHKNCFSSSICKLGQFDVNIGHHSYIRGRINCCEKELCEDQPFPGLPLSKPNGYYCPGAIGLFTKDSTEYEAICKGTETKCINIVGHRYEQFPGDISYNLKGCVSSCPLLSLSNATFEQNRNYLEKVECKDAIRLASL
What is the function of this protein?
Inhibits the PLA2 activity of crotoxin (CTX) by replacing the acid subunit (CA) in the CTX complex (PubMed:8195214, PubMed:1949070, PubMed:7851385, PubMed:10903514).  Displays a pro-inflammatory action through activation of important main signaling pathways for human leukocytes, in vitro (PubMed:32183984).  Abolishes both the muscle-paralyzing and muscle-damaging activities of CTX in mice phrenic nerve-diaphragm muscle preparations (PubMed:33387548).
What are the official names of this protein?
Phospholipase A2 inhibitor CNF, Crotalus neutralizing factor, CNF, Crotoxin inhibitor from Crotulus serum, CICS, Snake blood gamma-PLI, Sb-gamma-PLI, gamma-PLI.
What is the protein family that this protein belongs to?
Belongs to the CNF-like-inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in blood plasma.
Protein: ILVC_ROSCS
Sequence: MANIYYENHADLARLAGRTIAVIGFGSQGHAHALNLKESGCDVIVGLYQGSKSWSKAEGLGLKVLPVAEAAKEAQIVMLALPDTAQAAIYRDAIGPHMTPGKTLMFAHGFNIRFGQIVPPEGVDVSMVAPKAPGHRVREVYTQGGGVPALVAVHQDASGNALADALAYARGLGCTRAGVIETTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFYQGGLNYMRYSVSDTAEWGDYTAGPKIITDETRATMKRILADIQSGAFAEDWIEENHNGRPRFNAYRTRDIAHPIEQVGRELRRMMPFVNPREVVPGEGGA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: COX5A_MANSE
Sequence: MLKSASGALANVLKRSLVPAARVTAVVPLRRSHGGPVESDEEFDSRYEAFFNRKDIDGWEIRK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TSG10_HUMAN
Sequence: MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
What is the function of this protein?
Plays a role in spermatogenesis (PubMed:28905369).  When overexpressed, prevents nuclear localization of HIF1A (By similarity).
What are the official names of this protein?
Testis-specific gene 10 protein, Testis development protein NYD-SP7.
What is the protein family that this protein belongs to?
Belongs to the CEP135/TSGA10 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity).
Protein: YGFB_ECOHS
Sequence: MSIQNEMPGYNEMNQYLNQQGTGLTPAEMHGLISGMICGGNDDSSWLPLLHDLTNEGMAFGHELAQALRKMHSATSDALQDDGFLFQLYLPDGDDVSVFDRADALAGWVNHFLLGLGVTQPKLDKVTGETGEAIDDLRNIAQLGYDEDEDQEELEMSLEEIIEYVRVAALLCHDTFTHPQPTAPEVQKPTLH
What are the official names of this protein?
UPF0149 protein YgfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: ZFPP_MYCBO
Sequence: MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRRYGR
What is the function of this protein?
Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP).  Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall (By similarity).
What are the official names of this protein?
Short-chain Z-isoprenyl diphosphate synthase, (2Z,6E)-farnesyl diphosphate synthase, Z-FPP synthase, Z-isoprenyl diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family. Z-FPP synthase subfamily.
Protein: PTHP_PSEPU
Sequence: MPAREITIINKLGLHARAAAKFVGVAGRFPCQVPVGRAPDKLVDGKSIMAVMMLAAGKGTQVHLHTXGEQDSDAMDALVELINNFFDEGE
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain.
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSF1_CHAGB
Sequence: MPMYGDLGNKLVQHAKRTQNLTHLPPYQTELVRAVTREVRDLDKDVASLLEPFQGSFDPSTDQATACTLLVNHLSMRRNKRCLLAYHRTRTDKLEELVWNGSDVLDLAGQQAGGVNGAAADSGAGSSLSPQEEDYFRQYGDLLSAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAINLTKNSQFYVRQGDVERLIAQGYLQKLG
What is the function of this protein?
The GINS complex plays an essential role in the initiation of DNA replication.
What are the official names of this protein?
DNA replication complex GINS protein PSF1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRCB_ECOL5
Sequence: MLQLLLAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLAANLIGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTALAFWLFSASTAH
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UPPP_CHESB
Sequence: MAEQTIAQALMLGVLEGFTEFIPVSSTGHILLAGHFLGFQSTGKAFEILIQLGAILAVLSVYAGRLWKMLIELPHEPATRRFVLGILIAFLPAAIIGVVAYQIIKTVLFETPLLICTMLILGGIVLLWVDRWAKKPLYRDITQFPLSVYLKIGLFQCLSMIPGTSRSGSTIVGALLLGVDKRAAAEFSFFLAMPTMAGAFAYDLYKNYHLLTAADLQIIGVGFIAAFVAAVLVVRSLLDFVSRRGYALFGWWRIFIGVLGLIGVLVLG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRD2_MOUSE
Sequence: MAAGGRGLIRALHSSPCPTWKRAQSGANGRLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQICTDLELKKHGLKLHLRDPYSFTPMLEEGTLNRLPRSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPVDTTAFQHGSLLQRLRALSTLKPLLKAGRTLGAQLPQYYEVLTAPISKVLDQRFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGTQGAWSYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVNSEGRAQGVTLQDGEEVRSRVVLSCASPQVTFLELTPQEWLPGAFVKRISQLDTQSPVTKINVAVDRLPNFQAAPNAPGDQPQGHHQCSIHLNCEDTLLLHQAFEDAKGGLPSQKPMIELCIPSSLDPTLAPPGCHVVSLFTQYTPYTLAGGKVWNEQEKNTYADKVFDCIEAYAPGFKRSVLARDILTPPDLERIFRLPGGNIFHGAMSLDQLYFARPVPQHSDYRCPVQGLYLCGSGAHPGGGVMGAAGRNAAHVVFRDLKNM
What is the function of this protein?
Probable oxidoreductase that may play a role as regulator of mitochondrial function.
What are the official names of this protein?
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Note=The import into mitochondria is dependent on TOMM40 and TIMM23.
Protein: IOV7_CHICK
Sequence: MTDWVLHHKVGPLDMTTRYIFPLLPLPFLPHSESKRAVCAPRCSAMRTARQFVQVALALCCFADIAFGIEVNCSLYASGIGKDGTSWVACPRNLKPVCGTDGSTYSNECGICLYNREHGANVEKEYDGECRPKHVTIDCSPYLQVVRDGNTMVACPRILKPVCGSDSFTYDNECGICAYNAEHHTNISKLHDGECKLEIGSVDCSKYPSTVSKDGRTLVACPRILSPVCGTDGFTYDNECGICAHNAEQRTHVSKKHDGKCRQEIPEIDCDQYPTRKTTGGKLLVRCPRILLPVCGTDGFTYDNECGICAHNAQHGTEVKKSHDGRCKERSTPLDCTQYLSNTQNGEAITACPFILQEVCGTDGVTYSNDCSLCAHNIELGTSVAKKHDGRCREEVPELDCSKYKTSTLKDGRQVVACTMIYDPVCATNGVTYASECTLCAHNLEQRTNLGKRKNGRCEEDITKEHCREFQKVSPICTMEYVPHCGSDGVTYSNRCFFCNAYVQSNRTLNLVSMAAC
What is the function of this protein?
Serine protease inhibitor involved in antimicrobial egg defense preventing contamination of table eggs (non-fertilized eggs) and protecting the chick embryo (fertilized eggs) (Probable).  Inhibits trypsin, chymotrypsin, elastase, subtilisin and a proteinase of fungus Aspergillus oryzae (PubMed:13944692, PubMed:6904299, PubMed:6838526, PubMed:14519973, PubMed:14609095, PubMed:22010862).  Inhibits calcium-activated potassium channels KCNMA1 (bovine) and slo (Drosophila) (PubMed:8973172).  Has antibacterial activity against B. thuringiensis LMSA 3. 06. 004, but not against S. aureus CIP 103 811, P. aeruginosa PAO1, B. cereus ATCC6464 or B. subtilis ATCC 6633 (PubMed:22010862).
What are the official names of this protein?
Ovoinhibitor, OI, OvoI, Serine protease inhibitor Kazal-type 5.
What are the subcellular locations of this protein?
Secreted.
Protein: MCAT_BACIU
Sequence: MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLFQGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSILGGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLFEMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQLINFSEGEESAKQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPCVHNTLPGRE
What is the function of this protein?
Catalyzes the decomposition of hydrogen peroxide into water and oxygen (PubMed:33737179).  No significant activity could be detected with any of the other tested substrates, including glutathione, pyrogallol, NADH, NADPH and o-dianisidine (PubMed:33737179).
What are the official names of this protein?
Manganese catalase.
What is the protein family that this protein belongs to?
Belongs to the manganese catalase family.
Protein: AQR_MOUSE
Sequence: MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEEIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAETDGEFSLHEQTLLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVSDPALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVKNSGTACPDAAPDAAQVATFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSRKNGERPPHEVQVIKNMPQMANFVYNMYMHLIQTTHHYHQTFLQLPPAMVEEGEEGQSQETEMEAEEETVSAQGNLTPSPADASLSQETPAAQPDCSSQTEDTSAPCDIATAAEPVSAAAEAATPQDAESVPTETE
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis.  Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly.  May act by helping the folding of the snoRNA sequence.  Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.  Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
What are the official names of this protein?
RNA helicase aquarius, Intron-binding protein of 160 kDa.
What is the protein family that this protein belongs to?
Belongs to the CWF11 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Localizes to speckle- like regions of the nucleoplasm.
Protein: AMPA_NOSS1
Sequence: MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANSTVFTRVSSNIPVRKIILVGLGKTEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGFAGQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKFIHLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAASESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYGVRLLVDWVLSE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_WIGBR
Sequence: MIIENNKKKALEKALDKIEKQFGKGSIMTLGENRSMDIETISTGSLSLDIALGTGGLPMGRIVEIYGPESSGKTTLTLEVIYEAQKKGKICAFIDAEHALDPIYAKNLGVDINNLLCSQPDNGEQALEICDSLTRSGAVDLIIVDSVAALTPKAEIDGEIGDLHLGLAARMMSQAMRKLAGNLKNANTLLIFINQIRVKIGTIFGSPEVTTGGNALKFYASVRLDIRKIGTIKDGDIIIGNETRVKVVKNKISAPFRQAEFQILYGNGINTEGELITLGVNHNIIEKSGSWYSYNKNKIGQGKNNACNFLKNNPNISKEISRKIREINLIK
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_HALSA
Sequence: MEEFDVDLDFGGAGHTDDGDGLVAVIAQDADSRDVLMLAYATREAVARTATTGRAHYYSRSRDELWEKGATSGNTQSVDEIRVDCDGDALLYLVAQTGGACHTGHESCFHRTLDGDTVGDQVFDPDDAY
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_PELUB
Sequence: MKKLEVFGAAKLKGQIRISGSKNASLPILAATLLSNKKISLANLPRVKDIETMILLLKSLGSIIEDNKKELIIKNTKQTKTFAAYSLVKTMRAGILVLGPLLAKFGKAKVSLPGGCAIGTRPVDIHLQALSKLGVKYKIIQGYVHANAPKGLIGANIKFPKVSVGATENLIIAACLAKGKTTLSNCAIEPEIKDLVNFLINMGCNIKWTAKRTVRIEGVNNLKELDYSVMPDRIEAGTYLIAAALTEGNLKITGIDPKIISTEINILKKVGSKITLKKNEILIQGSKKIKNINIKTSPYPGFPTDLQAQMMVLLCKANKRSHIKEEIFENRFMHVAELNRMGAKISINGNQASIEGNIKFEAAELMATDLRASVSLILAALAAKGKSVINRIYHLDRGYEDIEKKLKKVGAKIKRIN
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSPN_BACC0
Sequence: MGNPKKNSKDFAPNHIGTQSKKAGGNKGKQMQDQTGKQPIVDNG
What are the official names of this protein?
Small, acid-soluble spore protein N, SASP N.
What is the protein family that this protein belongs to?
Belongs to the SspN family.
What are the subcellular locations of this protein?
Spore core.
Protein: MIAA_PARP8
Sequence: MMQRAPQPIACLLGPTASGKTAAALAFAARAPVEIVSVDSALVYREMDIGTAKPSSEERAVAPHHLIDIVDPVDAYSAADFRADALRLVGEIEARGNVPLLVGGTMLYYKALTQGLNDLPAADPEVRATLDADAAREGWPALHARLAAVDAVTAARLAPNDSQRIQRALEVFMLTGQPMSALLAAPARSDDLAKGYRFVPIALEPSDRSVLHARIAQRFDAMLAKGFIDEVRRLRARGDLHPGLPAMRCVGYRQAWEYLDGETDYDTMRDKGVFATRQLCKRQLTWLRAMPERIVVDCCAGDAAGLALQAIERVIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RSXA_SALPA
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLIYLRTLAFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.