PharMolix/UniProtQA huggingface dataset:
Protein: ISPD_MYCMM
Sequence: MAGGTQGVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLESGVVDTVVVAVPPDRTDEAKLILGREATIVAGGADRTESVSRALSALSAGVSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVLPLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAGVAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: HIS2_AZOBR
Sequence: MAEDKISAAVLDRLYATVQARKGADPETSYTAKLFHRGTAKIAQKVGEEAVETVIEAVRGDKAAMASESADLLYHLMVLWADAGLEPAAVWEKLAQREGTSGIAEKNARKS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APCD1_XENLA
Sequence: MGIPCFYSSLISCLFSIITLVDVGQSSALTLSDSRLHPQSLEKSPWREFQCQHMLKHLHNGARVTVQMPPNIEGHWVSMGCEVRSGPEFITRSYRFYNNNTFKAYQHYYGNNHCTIPTYTLVIRGKIRLRQASWIIRGGTEADYQLHNVQIIPHSETVAEKLTWLVNHTCAGFVPGDMPWEPGISYDLWREEGGFKCTKALNFAMHELQLIRVEKQYMHHNLDHLVEELFLGDIHTDPSQRMYYRPSSYQPPLQNAKNHNQNCVACRIILRSDEHHPPILPAKADLPVGLNGEWVSQRCEVRPEVLFLTRHFIFNDNNHTWEGFYYHYSDPICKHPSFTIYAKGRYSRGVYSSKVMGGTEFVFKVNHMKVTPMDFATASLLNVFNGDECGAEGSWKVGVEQDVTHTNGCVALGIKLPHTEYELFRMEQDNRGRYLLYNGQRPSDGSSPARPEKRATSYQVPLVQCTSVSLNPEGAHDGQHKSQSRNSAAGHIFLYLFSNLFLLFICTLLHLEILS
What is the function of this protein?
Negative regulator of the Wnt signaling pathway.  Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.
What are the official names of this protein?
Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein homolog, Protein primglo, xPgo.
What is the protein family that this protein belongs to?
Belongs to the APCDD1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS20_CLOBL
Sequence: MANIKSAKKRIKVIETKTLRNKMLKSSLKTTIKNFLTVVEGKNVEEAKAAYKTAARALDMSVSKGIVHKNKAARTKSRLAAKLNALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YWBO_BACSU
Sequence: MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPSPSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNKGHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKHAYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK
What are the official names of this protein?
Uncharacterized protein YwbO.
Protein: MNLOX_PLESI
Sequence: MVHNISLSSRKALHNVHLPYMVQLPKPTGYNVALKNAAEGYDKARRMVAWLYDIADYESSIPQTFTLQQKTDKYTWELSDNFPPHLAVVPPDQSVSAPSIFSPVRLAQTLLIMSSLWYDDHTDLAPGPEQNTMQKLTQWNQERHKDQGWLIKDMFNAPNIGLRNDWYTDEVFAQQFFTGPNSTTITLASDVWLTAFTSEAKAQGKDKVIALFESAPPNSFYVQDFSDFRRRMGAKPDEELFNDSDGAMRYGCAAVALFYLTAMGKLHPLAIIPDYKGSMAASVTIFNKRTNPLDISVNQANDWPWRYAKTCVLSSDWALHEMIIHLNNTHLVEEAVIVAAQRKLSPSHIVFRLLEPHWVVTLSLNALARSVLIPEVIVPIAGFSAPHIFQFIRESFTNFDWKSLYVPADLESRGFPVDQLNSPKFHNYAYARDINDMWTTLKKFVSSVLQDAQYYPDDASVAGDTQIQAWCDEMRSGMGAGMTNFPESITTVDDLVNMVTMCIHIAAPQHTAVNYLQQYYQTFVPNKPSALFSPLPTSIAQLQKYTESDLMAALPLNAKRQWLLMAQIPYLLSMQVQEDENIVTYAANASTDKDPIIASAGRQLAADLKKLAAVFLVNSAQLDDQNTPYDVLAPEQLANAIVI
What is the function of this protein?
Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 13S-hydroperoxy fatty acids.
What are the official names of this protein?
Manganese lipoxygenase, LOXPsa1, Valencene dioxygenase, ValOx.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
Protein: SYD_SALSV
Sequence: MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRARDAKNVNADMATGEIEVLASSLTIINRADSLPLDANHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELVDVADLLKSVEFAVFAGPANDPKGRVAALRVPGGAQLSRKQIDDYGNFVKIYGAKGLAYIKVNERAKGLDGINSPVAKFLTADIVEAILERTGAQDGDMIFFGADNKKVVADALGALRLKLGKDLSLTDEDKWAPLWVIDFPMFEDDGEGGLTAMHHPFTAPRDMTASELKTAPEEAVANAYDMVINGYEVGGGSVRIHNGEMQQTVFGILGINEQEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANQAALTELGIQVVKKAENN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_SALPK
Sequence: MSDVTVVNCPTCGKPVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIASSGDPSDSDDWSEER
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: YORZ_NEIGO
Sequence: MNASNWSVYLILCENSAFYCGISPNPQQRLAIHTAGKGAKYTRVFKPVAMRIVAGGMDKGTALKQEIAVKKLTAAQKRQLWEQAEKMPSET
What are the official names of this protein?
UPF0213 protein in glnA 3'region, orfZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: EFNB2_HUMAN
Sequence: MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
What is the function of this protein?
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
What are the official names of this protein?
Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction.
Protein: M2_I85A4
Sequence: MSLLTEVETPTRNGWGCRFSDSSDPLVIAASIIGILHLILWILDRLFFKCIYRLLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: VPX_HV2NZ
Sequence: MTDPRETVPPGNSGEETIEEAFAWLDRTVEAINREAVNHHPRELIFQVWQRSWRYWHDEQGMSTSYTKYRYLCLIQMAMYMHAKRDGTCLGGGMGQKGGDQGPPPPPPPGLV
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: RHCG_CANLF
Sequence: MVWNTNLRWRLPVTCLLLQVALVVLFGVFVRYDMDADPHWIDKKEAENSTSDMENEFYYRYPSFQDVHVMIFVGFGFLMTFLQRYGYSSVGFNFLLAAFGIQWALLLQGWFHSYYRGYIRVGVENLINADFCVGSVCVAFGAVLGKVSPVQLLIMTLFQVTLFSVNEFILLNLLEVKDAGGSMTIHTFGAYFGLTVTWILYRPGLHQSKERQSSVYHSDLFAMIGTLFLWMYWPSFNSAVSNHGDAQHRAAINTYCSLAACVLTSVALSSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGSLIVGFICGIVSTLGFVYLTPFLESRLRVQDTCGIHNLHGIPGIIGAIVGAVTASCANTDVYGVNGLTQAFGFDGFKTNRTPSMQGKFQAAGLFVSLAMALVGGIIVGIILKLPFWGQPADENCFEDAIYWEMPEEPKSTVLHPEDSTLKPSEP
What is the function of this protein?
Ammonium transporter involved in the maintenance of acid-base homeostasis.  Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism.  Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+).  As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity).  May act as a CO2 channel providing for renal acid secretion (By similarity).
What are the official names of this protein?
Ammonium transporter Rh type C, Rhesus blood group family type C glycoprotein, Rh family type C glycoprotein, Rh type C glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles.
Protein: TIMD4_MOUSE
Sequence: MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNTEDSDSVLNDMSHGRDDEDGIFTL
What is the function of this protein?
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).  Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways.  Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).  Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).  Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
What are the official names of this protein?
T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, Spleen, mucin-containing, knockout of lymphotoxin protein, SMUCKLER, T-cell immunoglobulin mucin receptor 4, TIM-4, T-cell membrane protein 4.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. TIM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y944_PYRHO
Sequence: MLELLPLLFGYLIMFFGALGVVRFPDVYTRLHAATKCDTGGIMGIILGLSMIVNSWAIRTKLVILLIFIAMINPMISHAIARGAYKGGVKPKVKVDMYAWDNP
What are the official names of this protein?
UPF0091 protein PH0944.
What is the protein family that this protein belongs to?
Belongs to the UPF0091 family.
Protein: ERL2_ARATH
Sequence: MRRIETMKGLFFCLGMVVFMLLGSVSPMNNEGKALMAIKASFSNVANMLLDWDDVHNHDFCSWRGVFCDNVSLNVVSLNLSNLNLGGEISSALGDLMNLQSIDLQGNKLGGQIPDEIGNCVSLAYVDFSTNLLFGDIPFSISKLKQLEFLNLKNNQLTGPIPATLTQIPNLKTLDLARNQLTGEIPRLLYWNEVLQYLGLRGNMLTGTLSPDMCQLTGLWYFDVRGNNLTGTIPESIGNCTSFEILDVSYNQITGVIPYNIGFLQVATLSLQGNKLTGRIPEVIGLMQALAVLDLSDNELTGPIPPILGNLSFTGKLYLHGNKLTGQIPPELGNMSRLSYLQLNDNELVGKIPPELGKLEQLFELNLANNNLVGLIPSNISSCAALNQFNVHGNFLSGAVPLEFRNLGSLTYLNLSSNSFKGKIPAELGHIINLDTLDLSGNNFSGSIPLTLGDLEHLLILNLSRNHLNGTLPAEFGNLRSIQIIDVSFNFLAGVIPTELGQLQNINSLILNNNKIHGKIPDQLTNCFSLANLNISFNNLSGIIPPMKNFTRFSPASFFGNPFLCGNWVGSICGPSLPKSQVFTRVAVICMVLGFITLICMIFIAVYKSKQQKPVLKGSSKQPEGSTKLVILHMDMAIHTFDDIMRVTENLDEKYIIGYGASSTVYKCTSKTSRPIAIKRIYNQYPSNFREFETELETIGSIRHRNIVSLHGYALSPFGNLLFYDYMENGSLWDLLHGPGKKVKLDWETRLKIAVGAAQGLAYLHHDCTPRIIHRDIKSSNILLDGNFEARLSDFGIAKSIPATKTYASTYVLGTIGYIDPEYARTSRLNEKSDIYSFGIVLLELLTGKKAVDNEANLHQMILSKADDNTVMEAVDAEVSVTCMDSGHIKKTFQLALLCTKRNPLERPTMQEVSRVLLSLVPSPPPKKLPSPAKVQEGEERRESHSSDTTTPQWFVQFREDISKSSL
What is the function of this protein?
Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ERL1 and ER.
What are the official names of this protein?
LRR receptor-like serine/threonine-protein kinase ERL2, Protein ERECTA-like kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MGSA_SACD2
Sequence: MKSRTGALPSRKQIALIAHDNKKQELSDWVCTHKKELEQHDLFATGTTGYKLAAETGLKVEKYISGPLGGDQQIGAKISTGEIDVLIFFWDPFEPMPHDPDVKALLRIAAVWNIPVACNPASADFVITSPLIKQSYERQIPDYEAYIAERTKKL
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: US35_HCMVA
Sequence: EHRHMTAHIIARNTNVAYAQRQTQLFAPPPHTRDFHTEVPLYALHGFRSDNNTAYLHMFHPHTSPPFMRYIHPKMKNQDTHNMILHIFFIETYRSGAGTFLVTHRHLRQ
What are the official names of this protein?
Uncharacterized protein HHLF2.
Protein: Y4991_PSEAE
Sequence: MPQALSTDILIVGGGIAGLWLNARLRRAGYATVLVESASLGGGQSVKSQGIIHGGAKYALHGALTGASEAIADMPRRWRACLGSDGELDLRGVRLLSEAHYLWSPGGLAGSLTSFFASKAVRSRVEQAKGEDLPPALRDKGFKGKAYRLTEIVFDVPDLIRRLAELAGDSLLAGERIEPLREGRELAGLCVDGREIRAQRVVLSAGAGNEALLRELGLEQPAMQRRPLHMVMVKAATLKPLYAHCLGAGPKPRITVTTHPTRDGQSVWYLGGDIAETDGVARDEAAQIAEARRELAKLLPWIDLGQAQWATLRVDRAEPAQSNLLRPDNAFLAEQGRLLVGWPTKLALAPDFADRVCARLEEDGIRPSEHAALPQLPRPPLAEPAWEVAFA
What is the function of this protein?
Probably functions as a FAD-dependent oxidoreductase, whose physiological substrate is unknown.  Does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities (PubMed:26841760).  Is essential for growth of P. aeruginosa in the sputum of cystic fibrosis patients (PubMed:25775563).
What are the official names of this protein?
Probable FAD-dependent oxidoreductase PA4991.
What is the protein family that this protein belongs to?
Belongs to the DAO family.
Protein: RL4_BRASB
Sequence: MELKVTTLEGKDAGSVQLSDAIFGLEPRVDIIQRCVQWQLNKRQAGTHKAKGRAEIWRTGKKMYKQKGTGGARHGSARVPQFRGGGRAFGPVVRSHATDLPKKVRALALKHALSAKAKDGDLVVLENATLEAAKTKALIGHFSGLGLTNALIIDGAELHNGFAAAARNIPNLDVLPIQGINVYDILRRQKLVLTKAAIDALEARFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CLPX_NOSS1
Sequence: MSKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVDLCNEILDEELLDTSGAAAQPAPKSEPPQKRRARSSNLSLSQIPKPREIKKYLDEHVIGQDEAKKVLSVAVYNHYKRLAILQSKGSGKNGDDAVELQKSNILLIGPTGCGKTLLAQTLAKILDVPFAVADATTLTEAGYVGEDVENILLRLLQVADLDVEEAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQGGRKHPYQDCIQIDTSNILFICGGAFVGLEKVVDQRGGKKSIGFVQPGEGQSKEKRAADVLRHLEPDDLVKFGMIPEFIGRVPMVAVVDPLDEEALMAILTQPRSALVKQYQKLLKMDNVQLDFKPDALKAIAQEAYRRKTGARALRGIVEELMLDVMYELPSRKDVTRCTVTREMVEKRSTAELLVHPSSLPKPESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: GNL1_MACMU
Sequence: MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAEVLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQEYLGKIHGAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPRTPQDPSSVLKKSRRRGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEEEEEDDGPAVLVEQQTDSAMEPTGPTRERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEEEGEEDRDADEEGEGDEDTPTSAPGSSLAGRNPYALLGEDEC
What is the function of this protein?
Possible regulatory or functional link with the histocompatibility cluster.
What are the official names of this protein?
Guanine nucleotide-binding protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Protein: GLCD2_SACS2
Sequence: MKAIVVKPPNPGVEIKDVKDDENKLSNIGLVKVKILENGICGTDREIVSGKRTSVKPPIGKDELILGHEAIGIVEVGGYGFKEGELVMPINKRGCGKCLNCLIGRPDFCETGEGLVAGTKGLDGFMREYLYDDPKYLVKIPPAIKDIAILAQPLADIEKSVESILTSQKRIPIWTCDDGTLNCRKALVVGTGPTGILFSLVLRTYGFQVWIANRRELLDNEKEILDEPRILFYNSAKGYESLVKDVDKFDLIIDTTGASASIIQELVPLLQINGVLGLFGFPRYDNFSLDYKIVQDFVINNRIIIGLDNGQKPHFQQALIHLASWKSLWPKTASKMITKIISINDEREVISSLREKLPGEIKVKIVWE
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone.  Can utilize both NAD(+) and NADP(+) as electron acceptor.  Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
What are the official names of this protein?
Glucose 1-dehydrogenase 2, GDH 2, GlcDH 2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
Protein: CXA3_HUMAN
Sequence: MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKASRASSGRARPEDLAI
What is the function of this protein?
Structural component of lens fiber gap junctions (PubMed:30044662).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity).  They are formed by the docking of two hexameric hemichannels, one from each cell membrane.  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:30044662).
What are the official names of this protein?
Gap junction alpha-3 protein, Connexin-46, Cx46.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: BLAC_PROVU
Sequence: NTNNTIEEQLSTLEKYSQGRLGVALINTEDNSQITYRGEERFAMASTSKVMAVAAILKESEKQAGLLDKNIIITKSDLVAYSPITEKHLATGMSLAQLSAATLQYSDNTAMNKILDYLGGPSKVTQFARSINDVTYRLDRKEPELNTAIHGDPRDTTSPIAMAKSLQALTLGDALGQSQRQQLVTWLKGNTTGDHSIKAGLPKHWIVGDKTGSGDYGTTNDIAVIWPKNHAPLILVVYFTQQEQDAKYRKDIIVKATEIVTKEFSNTSQKK
What is the function of this protein?
Hydrolyzes broad-spectrum beta-lactam antibiotics.  Active against cephalosporins.
What are the official names of this protein?
Beta-lactamase, Penicillinase.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: SYP_NITHX
Sequence: MRLSRFFLPILKETPKEAEIVSHRLMLRAGMMRQEAAGIYAWLPLGLRVLKKIEAIVREEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIQDRHKRELLYGPTNEEMITEIFRSYVRSYKSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDIDEVGARLSYNRMFVAYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVYIDKDVLDLPVPGTDVDYDGDLTPIVKQWTTAYAATEDVHDGARYEREVPEERRVHTRGIEVGQIFYFGTKYSESMKALVAGPDGVEQPIHGGSYGVGVSRLVGAIIEACHDDAGIKWPEAVAPFTVAILNLKQGAGDTDAACERLYRELSAKGVDVLYDDTDQRAGAKFATADLIGIPWQVMVGPKGLAEGKVEIKRRGDGTRENVALEDAVERLMA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_FRATF
Sequence: MSRRKVCRFTIEGVKEIDYKDVNKLKAYINETGKIVPSRVTGTSAKYQRQLATAIKRARFLALLPYCDRHFN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SYL_ECO27
Sequence: MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTEDQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.