PharMolix/UniProtQA huggingface dataset:
Protein: PRX2_PENRW
Sequence: MATLTETITSLAQPFVHLEDTINSPPVKETIRPRNDTTITPPPTQWSYLCHPRVKEVQDEVDGYFLENWKFPSFKAVRTFLGAKFSEVTCLYFPLALDDRIHFACRLLTVLFLIDDVLEHMSFADGEAYNNRLIPISRGDVLPDRTKPEEFILYDLWESMRAHDAELANEVLEPTFVFMRAQTDRARLTIHELGHYLEYREKDVGKALLSALMRFSMGLRFSADELQGMKALEANCAKQLSVVNDIYSYDKEEEASRTGHKEGAFLCSAVKVLAEESKLGIPATKRVLWSMTREWETVHDEIVAEKIASPDGCSEAAKAYMKGLEYQMSGNEQWSKTTRRYN
What is the function of this protein?
Aristolochene synthase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase prx9 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699) (By similarity).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase prx11 (By similarity).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, the conversion of eremofortin A to eremofortin C and then to PR-toxin requires only two enzymes (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:24239699).  The cytochrome P450 monooxygenase prx8 also plays a role in this step (By similarity).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:24239699).
What are the official names of this protein?
Aristolochene synthase prx2, AS, PR-toxin biosynthesis protein 2, Sesquiterpene cyclase prx2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: MNTP_DESAH
Sequence: MNFSTILLLAVALAMDAFAVAVAAGFQLRELTGRRIFRLSWHFGLFQALMPVIGWLSGKAVVSYIEAYDHWAAFILLCWIGANMIRESFDTSSDTPQKDPTRGARLILLSLATSMDALAVGFSLAALKVSIILPVVVIGVVALVFTWIGLLLGNRMLSSRKVGKQAELMGGGILILIGVKILHEHNVF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASPRX_ORYSJ
Sequence: MAKRHLLLVTTCLWALSCALLLHASSDGFLRVNLNKKRLDKEDLTAAKLAQQGNRLLKTGSSDSDPVPLVDYLNTQYYGVIGLGSPPQNFTVIFDTGSSNLWVPSAKCYFSIACYLHSRYNSKKSSSYKADGETCKITYGSGAISGFFSKDNVLVGDLVVKNQKFIEATRETSVTFIIGKFDGILGLGYPEISVGKAPPIWQSMQEQELLADDVFSFWLNRDPDASSGGELVFGGMDPKHYKGDHTYVPVSRKGYWQFNMGDLLIDGHSTGFCAKGCAAIVDSGTSLLAGPTAIVAQVNHAIGAEGIISTECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGSDAMCSVCEMAVVWIENQLRENKTKELILNYANQLCERLPSPNGESTVSCHQISKMPNLAFTIANKTFILTPEQYIVKLEQGGQTVCISGFMAFDIPPPRGPLWILGDVFMGAYHTVFDFGKDRIGFAKSA
What is the function of this protein?
Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles.
What are the official names of this protein?
Aspartic proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: KTHY_DICDI
Sequence: MINTKKEEGEEEKTMIKRGLFILFEGVDRVGKSTQVQSLTNHISNVQKLPTKSLRFPDRTTPIGQIINQYLQNATNMDDRALHLLFSSNRWEARDSILELLNNGTNIVVDRYSYSGVAYSAAKGIDFDWCYACEKGLPKPDLIFYLSMSSEDATKRGEYGGERYEKLEFQKKIKQIYEEKLVDDQWKIINANRSIDEISNEISSIFDSEFKKIQLTSIAKLE
What is the function of this protein?
Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: YIIE_ECOL6
Sequence: MAMNTVFLHLSEEAIKRLNKLRGWRKVSRSAILREAVEQYLERQQFPVRKAKGGRQRDEAVGVEELCKQHKE
What are the official names of this protein?
Uncharacterized protein YiiE.
What is the protein family that this protein belongs to?
Belongs to the YiiE family.
Protein: ARGB_STRMU
Sequence: MKDIIVIKIGGVASQQLSGDFLSQIKNWQDAGKQLVIVHGGGFAINKLMEENQVPVKKINGLRVTSKDDMVLVSHALLDLVGKNLQEKLRQAGVSCQQLKSDIKHVVAADYLDKDTYGYVGDVTHINKRVIEEFLENRQIPILASLGYSKEGDMLNINADYLATAVAVALAADKLILMTNVKGVLENGAVLEKITSHQVQEKIDTAVITAGMIPKIESAAKTVAAGVGQVLIGDNLLTGTLITAD
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASP6_SOYBN
Sequence: MKAGAVESGEISKGAPPRKGLIRGLSIMDFILRIVAAIATLGSALGMGTTRQTLPFSTQFVKFRAVFSDVPTFVFFVTSNSIVCGYLVLSLVLSFFHIVRSAAVKSRVLQVFLDTVMYGLLTTGASAATAIVYEAHYGNSNTNWFPFCRQYNHFCKQISGSLIGSFIAVVLFIILILMSAISISKH
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
CASP-like protein 6, GmCASP6.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: PPIL2_HUMAN
Sequence: MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATKRAAEEEPSTSATVPMSKKKPSRGFGDFSSW
What is the function of this protein?
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.  By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).  May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952).  Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
What are the official names of this protein?
RING-type E3 ubiquitin-protein ligase PPIL2, CYC4, Cyclophilin-60, Cyclophilin-like protein Cyp-60, Cyp60, hCyP-60, Probable inactive peptidyl-prolyl cis-trans isomerase-like 2, PPIase, Rotamase PPIL2.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=May also localize to the cytoplasm and the cell membrane.
Protein: K1C10_RAT
Sequence: MSVRFSSNSRQYSSARSGGGGGGGGGGSSIRVSSTKSSLGGGYSSGGFSGGSFSRGSSSGGCFGGSSGGYGGFGGGSFGGGYGGGSFGGGYGGGSFGGGYGGGSFGGGYGGGSFGGGSFGGGSFGGGSFGGGLGGDGGGLLSGNEKVTMQNLNDRLASYMNKVRDLEESNYELEGKIKEWYEKHGNSSQREPRDYSKYYKTIEDLKGQIVNLTTDNANVLLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLSKADLEMQIESLTEELAYLKKNHEEEMKDLQNVSTGDVNVEMNAAPGVDLTQLLNNMRNQYEQLAEKNRKDAEAWFNEKSKELTTEIDSNIEQMSSHKSEITELRRTVQGLEIELQSQLALKQSLEASLAETEGRYCVQLSQIQSQISALEEQLQQIRAETECQNAEYQQLLDIKTRLENEIQTYRSLLEGEGGYVGNLQITLNCFPSEFHLAKLTQTQGKTRGWKGSNTNKTRVIKTIIEEVTPEGRVLSSMIESETKKHFY
What is the function of this protein?
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).  Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, Type I keratin Ka10.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cell surface. Cytoplasm.
Protein: Y714_MYCCT
Sequence: MTKFIVNKNDQNQTLFKFLKKTFKTTPISVIYKWIRNKSIKINSKRVNDKNYLLKINDVVEVYDSNKPIIRDQFNYISNVNLDIVYEDNNILIVNKPNNLEMHSIYNLCLDDMVKSYLVDKKEYDIYLENSFVISHVHRLDKLTSGLVIYAKNKISSIILTNAFKTKDQINKYYYALTSYDWNLNDFLQVNGYINYNSNTQKADFSLVEKNNYKYCQTEFKLVNKNLILVKLITGKKHQIRSVLSFYNNPILNDFRYNGKKENDQKMIYLAAFKIEFKSLKKPLDYLNNKVIIKNPDWISRR
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase MCAP_0714, ORF2, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: MT21C_MOUSE
Sequence: MDQHLHIAQQPLLSGTPQEDGFAGPSVEFDRIESSLRSIQKFVPTDYASYTQEHYQFAGKKIIIQESIENYGTVVWPGATALCQYLEDHTEELNLQDAKILEIGAGAGLVSIVSSLLGAQVTATDLPDVLGNLQYNILKNTLECTAHLPEVRELVWGEDLEQSFPKSTCCYDYVLASDVVYHHYFLDKLLATMVYLSQPGTVVLWANKFRFSADYEFLGKFKQAFDTTLLAEYSESSVKLFKGILKWE
What is the function of this protein?
Protein-lysine methyltransferase.
What are the official names of this protein?
Protein-lysine methyltransferase METTL21C, Methyltransferase-like protein 21C.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPN5_MOUSE
Sequence: MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFSYAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFRLHTVTAVRKSSAVLEIHPESSSRFTSAHVMDGESHSNDGDCGKK
What is the function of this protein?
G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (PubMed:22043319).  Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319, PubMed:31607531).  Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (PubMed:30936473).  Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (PubMed:26392540, PubMed:30240620).  Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (PubMed:31607531).  Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (PubMed:30936473).  Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (PubMed:30936473).
What are the official names of this protein?
Opsin-5, G-protein coupled receptor 136, G-protein coupled receptor PGR12, Neuropsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRLF3_MOUSE
Sequence: MKGAMEPEPEVLLQEARENVEAAQSYRRELGQRLQGLREAQRQIKESASQTRDVLKQHFSDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTADDLVREGEIAILGGIEEESDKLWNFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTANHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQTGHSTLVPHEWTTGFEGYSLSSRRNIALRNDAESSGVLYSSAPTYFCGQTLTFRVETVGQPDRRDSIGVCAERQNGYESLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTSNSHEGGNAKLRVTISSNNREVVFDWLLEQACGPLYFGCSFFYPGWKVLVF
What is the function of this protein?
May play a role in the negative regulation of cell cycle progression.
What are the official names of this protein?
Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, CREME-9, Cytokine receptor-related factor 4.
What is the protein family that this protein belongs to?
Belongs to the cytokine receptor-like factor 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_ANADE
Sequence: MTDRYPSPRALLDRYDLRAKKSWGQNFLGEEAVLDDIARLAAPRAGDPVLELGAGLGHLTARLLARGARVVAVERDRDMARVLRGELGDRITLLEADAARLDHAALAARFGAPAAAGEGARLAVVGNLPYHLTSPILFSILDQVAHVSRAVFLLQREVAERLAAPPASRDWGLLSVLLQREAEVSVERIVPPGAFWPPPKVESAVLCALFRPPADAVGDPARFRRLVKAGFGLRRKTLRNALGSAKLAEPARLEAAFAAAGVDPGRRGETLTLAEWAALDRALG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMEB1_RAT
Sequence: MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHTIHKIEEGIDASSIEANEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIHAPFQVTDAAVLNNVANTFGLMDTVKRVLDNRRKQVEHGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGTSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSTLGNMATMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEADDPEGKAVILETELRTEEKVVANMEERQHQVHNVEIVVLED
What is the function of this protein?
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids.  Binds also to the transferrin receptor promoter (By similarity).
What are the official names of this protein?
Glucocorticoid modulatory element-binding protein 1, GMEB-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Protein: HSLU_RHILW
Sequence: MTTFSPREIVSELDRYIIGQHDAKRAVAIALRNRWRRQQLDPSLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEVGIGLVREKKRTEVQAKAHVSAEERVLDALVGTTASPATRESFRKKLRDGELDDKEIDIEVADAGSGMGGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVKASYTDLIRDESDKLIDNEVIQREAVRSTENDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHILFIASGAFHVSKPSDLLPELQGRLPIRVELRPLNKEDFRRILTETEASLIRQYRALMETESLNLEFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDDISYNAPDRGGTAVTIDAAYVREHVGDLAQNTDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_LISMO
Sequence: MLVSYNWVKEFFQDFPLTAEELGEAITRTGIEIEGVEELSASLKNVVVGEVLSCERHPDAEKLNKCLVQTDEAEPVQIICGAPNVAAGQKVIVAKVGARLPGGLKIKRAKLRGEVSEGMICSLAELGFESKVVPKAYAEGIYVLPAHVETGVNAITLLGLDDAILDMAITPNRADALSMKGVAHEVGAIIHQKPAQPTEPDVSEKGKAEDFISVEVENPAETPYYAIKMVENIEIKESPLWLQTKLMKAGIRPHNNVVDVTNYINLLYGQPLHSFDYDKIGSKKIVVRSAKEQEEITTLDGEKRTLQAGHTVITNGVEPIAIAGVMGGEFSEVTENTTTVALEGAIFSSSSIGKASRELYLRTEASIRYDKGSDAWKVEKALAHGGALIAELSGGTLVGGVVEVDNREKAVNKIETSLTRINRILGTAITLTEIETIFDRLGFVLEVKNDALIIEVPTRRWDITIEADILEEVARIYGYDEIPVTLPATSTTGGLSDSQKARRVMRAYLEGAGLNQALTYSLTSKKDATRLALSDEKTVALSMPMSEEHSHLRTSIVPQLIRSASYNIARKNMDVALYEMGTVFYATEGDNLPIEQEHLAGLITGNWHIADWQKTPKPVDFFVLKGIVEGLVNKLGIKSELHWKQTEKEELHPGRTASLVLEGQEIGYLGALHPAVEANYDLKETYVFEINVAALLDATKEKVVYHPIPRYPEMTRDLALLVDKDTNHAAISQVIKEHGGKLLVDIELFDIFEGESLGENKKSLAYTLTFLDSERTLVEEDVQKATNKVVEALQEKLNAIIR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACON2_EMENI
Sequence: MLRQIVSQRSAARRQLIDQLAPCLRRGLATATDSTPTSSRMPPYSKIVQNLEQVRKVLGSSRALTLAEKILYSHLDNAEESLLTGTNNGRDIRGKADLKLKPDRVAMQDASAQMALLQFMSCGLPSTAVPASIHCDHMIVGERGADTDLPASIQGNKEVFDFLESASKRYGIEFWPPGAGIIHQSVLENYSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALVDAPWELKAPRILGVRLEGKLQGWAAPKDIILHLAGKLTVRGGTGFVIEYHGPGVETLSTTGMATICNMGAEVGATTSLFPFSPNHVPYLKATNRADVAEAAAKIASAGSSSLLRADTSAEYDELITIDLSTLEPHINGPFTPDLSVPLSRFAETVRKNNWPETFNAGLIGSCTNSSYEDMTRAEHLVKQANAAGLKPKADLFITPGSEQIRATLDRDQTLSTFSSAGGTVLANACGPCIGQWKRTDDVPKGTDNAIFTSYNRNFPGRNDGNRRTMNFLASPELVTALTYAGSTTFNPVTDSITTPSGSEFRFEPPTGQDLPSKGFEAGNPAFQPSAPVPDSSVEVKVSPTSTRLALLEPFAPFPNSDLQNLSVLYKVKGQCTTDTISAAGPWLKYKGHLPNISANTLIGAVNAATGETNVAYDEAGKQHTIPDLAAQWKAQGREWLVVAEENYGEGSAREHAALQPRYLGGRVILAKSFARIHETNLKKQGVVPLTFADKADYDRIDACDVVATEGLYETLKNGGKGEVKLRVTKKSGEEIVIPVKHTLSADQSSFILAGSALNVLSKR
What is the function of this protein?
Has no detectable activity towards cis-acontiate or cis-homoaconitate.
What are the official names of this protein?
Putative aconitate hydratase, mitochondrial, Aconitase 2.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CA16B_CONLE
Sequence: VVLGPASDGRNAAANNKASDLIRQICCGYGDCGFVPNVCV
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like Lp1.6b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SURE_METBU
Sequence: MSKRILLTNDDGVYAAGIRAAYRSVSDLGDVTVSAPAQQQSGVGRSISIFEPLRITRTTIDGIEVHAIGGTPTDSVILGIFTIMKELPDLILSGFNIGENISTDTITTSGTIGAALEGASYGVPAIAASLQVTEEGLKFDDLRDFQHDFDVGIKFVNGVAKKVLKNGLPENVDLLNINIPHFVEEDSEVEITRLARKFFRTGVEERRDPRGRPYYWIAGDLIHTAEKGTDVNAIEKGHISVTPISLDATSPINFSEIEHLM
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP10_TRYCR
Sequence: MHLQVYIVNGKRQYTLKKMDPEGKPTLSAHPARFSPDDKYSRHRITIKRRFKALKSEKRPKPL
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 3-like protein, Nucleolar protein 10, Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FMT_CROS8
Sequence: MSESLRIIFAGTPDFAARHLDALLSSSHQVVGVFTQPDRPAGRGKKLMPGPVKVLAQENDIPVFQPKSLRSAENQELVAALNADVMVVVAYGLILPEAVLSMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDKGLDTGDMLRKLSCPITADDTSASLYDKLAQLGPQGLLATLEDLAAGRAVPEKQDDAQATYADKLSKEEARLDWTLSAAQLERCIRAFNPWPVSFFMIDEQPVKVWKASVIRQQSHATPGTILDAGKQGIQVATTDGILNLESLQPAGKKPMSAQDLLNSRREWFTPGAILA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CEP3_MUHVK
Sequence: MGAECCKQLCRSLHPYAADSLKDSSGRRVDLGTEFSVLTDTSDDEDQVGAGERDDFVQKQLTTPLLSDKNSAIPLTVVTPIQLGANKGGGKRTSSLKSAKNGAGVKKKVRAL
What is the function of this protein?
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes.  Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
What are the official names of this protein?
Cytoplasmic envelopment protein 3.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.
What are the subcellular locations of this protein?
Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: SEPF_CLOAB
Sequence: MASKVLNKVMGIIGLNDEDFDEYEDEVMEEKAIARENSYDYDEKLNDKNSSNSNNKVVNIHTASSVKVVIVKPKDYDEATQICDDLKNRKIVVVNVTDLEPKTAQRLLDFMGGASYVLNGELLEIDKGVYLLSPSNVDISRDLKNDLASKSIFNWSK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.