PharMolix/UniProtQA huggingface dataset:
Protein: MATK_AMOBY
Sequence: MEELKGYLEKSRSKQQHFLYPLLFQEYIYVLAHDHGLNVNGSIFYEPAEISGYDKNFSSLLVKRLITRIYQQNYLINSVNDSNQNGFVGHNKNFYSQMISEGFAVIVEIPFSLRLVSSLEGKKEIPKSQNLRSIHSIFPFFEDKLSHLNCVSDILIPYPVHLEILVQILQCWIQDVPSLHLLRFFFHEYQNWNNLITPKKSNYYGFSKENPRLFLFLYNSYVVECESILVFLRKQSSYLRSTSSGTFLERAHFYEKIEQHLVVLCCNDFQKTLWLCKDPFMHYVRYQGKSILSSKGTHLLMKKWKSYFVNFWQCHFHFWSQPCRIHINQFSNFSFYFLGYLSSVPINPSAVKSQMLENFFLVDTVTKKFETIVPIIPMIGALSKAKFCNVSGNPISKPVWADLSDSDIIDRFGRTCRNLSHYYSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRAFLQRLGSEFLEEFFTEEEKALSLILPRISYPLHKLYRERIWYLDIIRINDLVNHL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KDPA_MAGSA
Sequence: MDAHGVLQFLLFLALVLALTPILGRFMTWLFQAPVGRVEDGFYRLLGIDPTREQGWAAYAVSLLIFHLLAVFGLYALQRFQGMLPLNPAGQGAVPPDLAFNTAISFATNTNWQNYGGESTMSHLTQMAGLTVHNFLSAAAGIAVAVALMRGFARHSTRTVGNFYVDITRVTLGLLLPLCLVGALVLVGQGVPQNFDAPVTVTTLEGVSQVIAQGPVASQMMIKHLGTNGGGFFNANAAHPYENPNALVNLIHMLAIFAIGAALTNTFGRMAGDRRQGWALLGAMAALFLAGLGAAWWAEAQGNPVLGGIANMEGKEVRLGVAASMLFAVVTTVTSCGAVNAMHDSLLPLAGMIPMVNMLLGEVVVGGVGSGLYGMVVFALLTVFIAGLMVGRTPEYLGKKIEAREIKLAVIAILATPVAVLGIGGLAITLPMGQAGIAAAGPHGLSEVLYAFASAGNNNGSAFGGLSGNTIFYNATMAAAMMIGRFVVMIPVLAIAGALAAKMAVPASAGTFPTHGWLFVVLLVGIVLVVGGLTYFPVLVLGPVVEHLALSAGILF
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRM8_MOUSE
Sequence: MVCEGKRSTSCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRLDGDIILGGLFPVHAKGERGVPCGDLKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Signaling inhibits adenylate cyclase activity.
What are the official names of this protein?
Metabotropic glutamate receptor 8, mGluR8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIG_VIBC3
Sequence: MASIDLASTPLTATQNVDPNEIKKFEDMASRWWDLEGEFKPLHQINPLRLNYVLEKANGLFGKRVLDVGCGGGILAESMAREGAQVTGLDMGKEPLEVARLHALETGTKLTYIQSTVEAHAEANPHTYDVVTCMEMLEHVPDPLSVIQSCAKLVKPGGHVFFSTLNRNVKSYLFAIVGAEKLLKIVPEGTHDHNKFIRPSELLKMVDHTALQEQGITGLHYNPFTDTYRLGSNVDVNYIVHTRLF
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: CYHED_AFREN
Sequence: GFPCGESCVYIPCFTAAIGCSCKSKVCYKN
What is the function of this protein?
Probably participates in a plant defense mechanism (By similarity).  Has strong cytotoxic activity against HUVEC cells (LC(50)= 0. 58 uM) and various cancer cells including HeLa (LC(50)= 0. 48 uM), MCF-7 and K562 (PubMed:32414842).  Also displays some hemolytic activity (PubMed:32414842).  Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (PubMed:32414842).
What are the official names of this protein?
Cyclotide hyen-D.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: GLYA_SYNSC
Sequence: MSQASGRAIDADLAQSDPDIAAFINQERQRQETHLELIASENFASRAVMQAQGSVLTNKYAEGLPSKRYYGGCEHVDAIEELAIERAKQLFGAAWANVQPHSGAQANFAVFLALLQPGDTIMGLDLSHGGHLTHGSPVNVSGKWFNVVQYGVDKETQRLDMEAIRQLALEHKPKLIVCGYSAYPRTIDFAAFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCDVVTTTTHKTLRGPRGGLILCRDAEFAKKFDKAVFPGSQGGPLEHVIAAKAVAFGEALQPSFKAYSQQVVANAAALAEQLIARGIDVVSGGTDNHVVLLDLRSIGMTGKVADLLVSDVHITANKNTVPFDPESPFVTSGLRFGTAALTTRGFDSQAFREVADVIADRLFNPEDDAIRQRCLDRVGALCERFPLYADSKHKQPVLV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_SODGM
Sequence: MAHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMMNVALNSGTLQHPIKGVHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDALGNMKSPEMVAAKRGKSVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: Y1687_CLONN
Sequence: MFNTLKILDLPENERPRERLIKYGSQALSNSELIAIILGTGGRNENVLSLSSRILKQCEGLNGLLTLTPEEIMTLKGIGSAKAAKIIAVGELAKRFKAYKSGDVYIIKSPGDVAGLVMEEMKYFKEEHLRVIMLNTKNIVISCKDVSIGSLNSAIVHPREVFCEALKKNSASIVICHNHPSGDPTPSSEDINVTKRLKQCGIILGINLLDHLIIGHSNYISLKEKNIL
What are the official names of this protein?
UPF0758 protein NT01CX_1687.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ACPS_BACAA
Sequence: MIVGIGIDIIELNRIEKMLDGKLKFMERILTENERNVAKGLKGSRLTEFVAGRFAAKEAYSKAVGTGIGKEVSFLDIEVRNDDRGKPILITSTEHIVHLSISHSKEFAVAQVVLESSSS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTF4_ARATH
Sequence: MDCLQMVFKLFPNWKREAEVKKLVAGYKVHGDPFSTNTRRVLAVLHEKRLSYEPITVKLQTGEHKTEPFLSLNPFGQVPVFEDGSVKLYESRAITQYIAYVHSSRGTQLLNLRSHETMATLTMWMEIEAHQFDPPASKLTWEQVIKPIYGLETDQTIVKENEAILEKVLNIYEKRLEESRFLACNSFTLVDLHHLPNIQYLLGTPTKKLFEKRSKVRKWVDEITSREAWKMACDQEKSWFNKPRN
What is the function of this protein?
May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
What are the official names of this protein?
Glutathione S-transferase F4, AtGSTF4, GST class-phi member 4, Glutathione S-transferase 31.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Phi family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SYA_JANMA
Sequence: MNSSEIREKFLKFFESKGHTIVASSPLVPGNDPTLMFTNSGMVQFKDVFLGEDKRPYTRATSVQACLRAGGKHNDLENVGYTARHHTFFEMLGNWSFGDYFKRDALKWSWELLTQVYGLPAEKLLATVYIEDDEAFDIWTKEIGLPPERVIRIGDNKGGRYKSDNFWMMADTGPCGPCSEIFYDHGPHIAGGPPGSPDEDGDRFIEIWNNVFMQFDMAEDGSVKPLPAPCVDTGMGLERLAAILQHVHSNYEIDTFEALIKAAGRETNTKDLSNNSLKVIADHIRATAFLVADGVIPSNEGRGYVQRRIIRRAIRHGYKLGQKKPFFHKLVKDLVEQMGEAYPKLKADAQRITDVLKAEEERFFETLANGMEILDAALAGDAKVLPGEVAFKLHDTFGFPLDLSADVCRERGLSVDEAGFAAAMEKQKAAGRAAGKFKMERAVEYTGAGNTFTGYEHLEEQATVVGLYFEGTAVPSLKEGQAGIVVLDTTPFYSESGGQVGDQGFISAEGVQFGVEDTQKIKADVYGHHGVQTQGTLTVGDKVKAAVDGARRAATMRNHSVTHIMHKALREVLGDHVQQKGSLVDPDKTRFDFAHNAPVTREQILEIEKRVNAEILLNSDTQARVMDIESAQKTGALMLFGEKYGETVRVLDIGSSRELCGGTHVSRTGDIGLFKVMSESGVAAGVRRIEAITGAKALGYVQDLEAVIHSAAAMMKTQPAELEPRLAQVLDQMKALEREVGALKGKLASSQGDELLAQAVDVKGIKVLAAVLEGADVATLRNTMDKLKDKLKTAAIVLAAVNDGKVSLIAGVTADSIAKVKAGDLVNFVAQQVGGKGGGKPDMAQAGGTDASGLPTALQGVAAWVGERA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TE4_HUMLU
Sequence: MMTPIGIRIRKQIPLSYHYSSIQALLSRFTPTPYNPISNSSSSTQTIPTQFHESQCTNPISRPTVFLFDPPPIRFTHTKSFSTDPSSLDFPSNQPPVVSTISSHHNISQPIDAGSSIRKPISLWPGMFNSPVTNALWEARSNMFEKYGEPTADPPSQSELVTKSPAQSRTSILYNLSSDYALREHYRNPWNMIRIGKLLEDLDALAGTIAFKHCTNEDGMSRPLLLVTASVDKMVLKKPISIDTDLSIVGAVTWVGRSSMEIQLQVLQTTHESSDPSDSVSLVANFTFVARDSKTGKSAVINQISPETGEEKLLWREADERNKMRKMKRKIQKDLELEKQYIERLNALLAEGRVFCDLPALADRNSILMKDTCLENSFICQPQQRNIYGRIFGGFLMRRAVELAFSTTYSFAGVVTHFLEVDHVDFLRPVDVGDFLRLKSCVLYTELQNPTEPLINVEVVAHVTRPELRSSEVSNKFYFTFSVGPEAVKDGLLVRNVVPATEEEARRVLERMDAETPHPHSQYENEI
What is the function of this protein?
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:23300257).  Active on acyl CoAs with short chains (propanoyl-CoA and butanoyl-CoA), branched short chains (2-methylpropanoyl-CoA, 2-methylbutanoyl-CoA and 3-methylbutanoyl-CoA) and medium chains (octanoyl-CoA) (PubMed:23300257).
What are the official names of this protein?
Acyl-coenzyme A thioesterase 4, mitochondrial, Acyl-CoA thioesterase 4, HlTE4, 2-methylbutanoyl-CoA hydrolase TE4, 2-methylpropanoyl-CoA hydrolase TE4, 3-methylbutanoyl-CoA hydrolase TE4, Acyl-CoA thioester hydrolase 4, Butanoyl-CoA hydrolase TE4, Propanoyl-CoA hydrolase TE4.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CSPL4_RICCO
Sequence: MRSPQSLRNGETPSPSPRPPRFPTPHFHSTVSLQKLKRFNLLILVFRLSTFCFSLASSVFMLTNPTWYHFDAFRYVFAANAIVAIYSLFEMAASVWEISRGNTLFPEILQVWFDFGHDQVFAYLLLSADSAATALAKTLKGGDTCAASNAFCVQSYIAIALGFAGFLFLGLSSLLSGFRVVCFLINGSRFYV
What are the official names of this protein?
CASP-like protein 4C1, RcCASPL4C1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU1_BUCAP
Sequence: MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENAGIDIIEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLNKDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKKNFDQIIDMAISSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEQLIKAGVKTINIPDTVGYTVPNELSTIIHNLFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKECDYNIDELYTSFLKLADKKGQVFDYDLEALAFINMQQEESEYFSLSFFSVQSISNGLSTASVKLLCGKKVSIESATTSNGPIDAIYQALNRITNFPITLQKYQLVAKGKGRDALGQVDILVEYKKRKFHGVGLATDIIESSAQAMVNVLNNIWKANQVNEKLKTLKKVNN
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: OBSL1_RAT
Sequence: MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVLWEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPQSSECPPPPPGTGEGAPVFLTGPQSQWVLRGAEVVLTCQVGGLPEPKLYWEKDGMALDEVWDSSHYTLEPDRGASDGGASLTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPHENPPQDPDEPPVRVIEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLVIHRLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDGEELPATCQSSCGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPVLVEMFKGQKNTVLLTWKPPEPPPETSFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPTEGDYRFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLEDVQVYDGEDAVFSLDLSTIIQGSWFLNGELLKNDEAEGQVEPGALRYRIEQKGLQHRLILQTVKHQDNGALVGFICPGVQDSAALSIQESPVHILSPQDKVLLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESESLVVKMDGRKHRLILPEAQVRDSGEFECRTEGISAFFSVTVQDPPVHIVDPQEHVFVHAITSESVMLTCEVDREDAAVHWYKDGQEVEESAVIVLEKEGPRHRLVLPAAQPSDGGEFQCVVGDERAYFTVTITDVSSWIVYPNGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVLESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEIHDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSRVDAPVRWYKDGLEVEETEALVLQSDGPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPVARSLDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPEDAGEYVCETRDEAVTFNVSLAELPVQFLAPEAVPNPLCVVPGEPVMLSCELSRASAHVSWSHNGNPVKQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGTAPGAPSLSFNVQVAEPPPVKLVSELTPLTVHEGDDATFQCEVSPPDAEVTWLRNGAIVTPGPQLEMVHSGSSRTLIIRGCQLKDAGTVTARAGATDTSARLHVRETELLFLRRLQDVRAEEGQDVYLEVETGRVGAPGAVRWLRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGCESHHDRTLARLSVRPRQLRELRPLEDVTVHEGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCHIHSEGRTHCLVLSGLGLADSGCISFTADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECELSQTLADVIWEKDGQALSLSPRLRLQSLGTRRLLLLRRCSSSDAGTYCCAVGTARSGPARLTVREREVSVLGELRSLSAREGDSATFECTVSESETTGRWELGGRALRPGGRVRIRQEGKKHILVLSELRTEDTGEVCFQAGPAQSLARLEVEALPLQMCRRPPREKTVLVDRRAVLEVTVSRPGGHVCWMREGVELCPGSKYEMRSHGTTHSLVIHDVRPEDQGTYSCQAGQDSADTQLLVEGDD
What is the function of this protein?
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity.  It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity).  Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.  Required to localize CUL7 to the Golgi apparatus in neurons.
What are the official names of this protein?
Obscurin-like protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
Protein: BOREA_RAT
Sequence: MAPKKRSSRGTRTNTLRSRKLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEVLRLPKALQVMKWLDYFALGGNRQALEEAATADRDITEINNLTAEAIQTPLKSVKKRKVIEVDEAIKEEEEDEEEEGGGGGGRKSHKNLRSARVKRCPPSKKRTQSIQGRSRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRVDIAQLNPEALGNIKKLSSRLAQICSSIRTGR
What is the function of this protein?
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  In the complex, it may be required to direct the CPC to centromeric DNA (By similarity).
What are the official names of this protein?
Borealin, Cell division cycle-associated protein 8.
What is the protein family that this protein belongs to?
Belongs to the borealin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Protein: OME1B_MAGO7
Sequence: MSTMALHRTASTKSDTTMACPNGLVKNLPLGGNTKCSACGSHRAEKRRASSTSSVSTTPTSPSFSEADWSPLHNSSQEPQPEYTKVANSLMRAITDYVGHLQNENLPMPSLEPAADAHGVLKHPEGVAARNAVVELAQRIVAMTMDPDMNLLISSLQFHFCSSLKVAIDLKVHEHVPRRGSITSSELAAKVGADESILVRIMRALILKHVFCSPTPGTYAHTAMSWCMMKSPDAIDLLGHRLDESFRASSRQADALALVNYREPDEADVKGFSMAFGTTENFWEVLGHEGEEERAQRFNRAMRAVSLNTLDVIPRMYPFDRIRGDGLLVDVGGGLGQVARAIMGAHRGAGLRSCIVQDAHAGDDAKKQPDVMEANRKLGVELQKHNFFDPQPVKGASVYFLRHIFHDWPDRACVKILKQTVEAMGKDSTLLICDQVVDDEASPQATLYDIDMWSLFGGKERNRSEWEALFRSADERLYIKKVWTTAEAPTTMLEVCLS
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars (PubMed:18433432).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone (PubMed:29142718).  The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor (PubMed:29142718).  Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1 (PubMed:29142718).  Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable).  The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds (PubMed:31644300).  Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars (PubMed:18433432).
What are the official names of this protein?
O-methyltransferase OME1, ACE1 cytochalasan biosynthesis cluster protein OME1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: Y1670_MAGMM
Sequence: MPSFDIVSEVDLQEVDNAVNQTVKEITTRYDFKGSKSTLTREDAVITILADDAYKLEQVTEVLKGKMVRRSVDPHFLDFGTVEPASGAMVRQNVTVKQGIESEFAKKIVKTIKNAKLKVQAAIQGDQVRVTGKKRDDLQEAIALLKSQSFEQPLQFNNFRD
What are the official names of this protein?
UPF0234 protein Mmc1_1670.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: REC10_SCHPO
Sequence: MDIFSEFLNCLSSDGTLNESSIYKTYQILESLNPKDVDTKENYIKLSNTFSTLGSGVGFQDNLLIEMFKILTVLFFKTRSTDLGDLLIESFTSLEIEKLMRVKKTIGSIVLTKGIQELQEIELPKVGFNCMTYDESIFQGISLERLILQLMSIFIAKCEENKLWLVNNRKDLDLRVIGQRLLHRDFACRFLSGLFISRFSVSGDTDESKHQNGIRLQLFIDFSKFETRLTMQILKADRIFSTCVANTVHAYEGLFSSGSNIDSTIATLVLEPRDLIVYRKGFALLQIPWTSVTTIDKIKKVKSLKIITEVSSLDEFVFQCKDGDKFDELFSTSEEIMNKLLPAIIVSPKLTLRNRSIIQIKEGESKLPNTSKQASQNLPHLDDELAYQRFEDQVIDKSVCDDECTNTENTPSSNIPADVKDSLSADDYAYDTKRKTQIEDLEEDQNKSKIASKDGTNLKEINSVPEFSDENVINQTGPAKKTPVQRRKDGKFAKSTKRKKQKSLKPDTENQESSVKNKKAKSNVNLQYSPKTPICKINDETLKPPTIANIAGHKQMNHLTSENIETPVPVPNGNWYNGVKHETATDIFTTCHDGNNSLKSSVWKELLKEKHWKQESKPQLTGNSRQIDLSTFVKQANTPNITSLLDGTCSSPPNNECFNDKEPDSSSSTLISDRQELEYRNPNAETVKLEEIPYNKFFKTVEKNEAYNPSSKSATIDGLQRYTSMIGNQIYEGILQNEKELRSKLEAYHINCNKVIKEFSKRQTARYKIIEKELAQIEVNLVSQIDSLMFK
What is the function of this protein?
Organizes linear element components on chromosomes and is thus required for meiotic DNA recombination.
What are the official names of this protein?
Linear element protein rec10, Meiotic recombination protein rec10.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to DNA double-strand break (DSB) hotspots.
Protein: GRC3_ASPNC
Sequence: MKRKAEKAQAAAPVSAFAARKARQQQAQATAAAVKPPVAEPVVEPPPKRARRSLEEPVVPVAPEENRVQTRRSSRRKEEQAKVEKPTPKARNDQPPKASKKLPEHDTSKATEDQAPSDEESEEPDVVVGNTGVIGLEPIQNEEEGYESPADTAVQVQDFPLSKARLNKNSIVYSDEHRMCVRIKEKMSLVMIGHYDLWVKRGVVSLMGAKLHPSSQVYRVYAPSTHSLPVIKCVSGVNGEAEVEFKSCHSGIYRLKELSPLYQRIWNGKNTTADKLTLKGTPQSTKRTFSVLYTSADDSFKRHLRPLHLEKQWSSAIKSLSQRGGRLKTLICGPKGSGKSTFSRYLLNHLLSPAPQTETKYFNTDGVAFLDLDPGQPEFAPMGQVYLAHLRSPVFGPPFSHPSLDGSRNGTIVRSHHIGATSPKEDPDHYVLAAMDLMDRYRALQASYPQCPLIINYPGWIFGLGLEVATWLVRSLGLSDVVYMSEKGPTEVVQPLGQAAYQAKIPLTILPSQPTDFVSRSSAQLRSMQMQSYFHMSRPNGINNSLWLEQPLSRTKPFRVHYSGPQQGIQGIMVMGTEIHPDLLHEVLDGSIVAVVAVESPNAILGQNSGPMFANNANAETDGDHDVDMQDSADAVPVIGTSTIESSITRTPNEDLPYLFVGAGSSNPLDPKVSHCLGLALVRSVNVASRQLELVTPITGSTLRGVLEQGHSIVLVRGLLDNPNWAISEDYYAARAAEKRHRELIEKLKKDKGAAAAEDATLESEKQVLKDRIRRASKVPWMTVVEDNSRRQREAAQREKSLWKLRKKAYPGSDSEGDW
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase grc3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.