PharMolix/UniProtQA huggingface dataset:
Protein: JUNO_HUMAN
Sequence: MACWWPLLLELWTVMPTWAGDELLNICMNAKHHKRVPSPEDKLYEECIPWKDNACCTLTTSWEAHLDVSPLYNFSLFHCGLLMPGCRKHFIQAICFYECSPNLGPWIQPVGSLGWEVAPSGQGERVVNVPLCQEDCEEWWEDCRMSYTCKSNWRGGWDWSQGKNRCPKGAQCLPFSHYFPTPADLCEKTWSNSFKASPERRNSGRCLQKWFEPAQGNPNVAVARLFASSAPSWELSYTIMVCSLFLPFLS
What is the function of this protein?
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization.  The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion.  The ligand-receptor interaction probably does not act as a membrane 'fusogen'.  Does not bind folate.
What are the official names of this protein?
Sperm-egg fusion protein Juno, Folate receptor 4, Folate receptor delta, FR-delta, IZUMO1 receptor protein JUNO.
What is the protein family that this protein belongs to?
Belongs to the folate receptor family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=GPI- anchored at the oolemma.
Protein: OBG_LISMO
Sequence: MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGRGAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLADVGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVIVHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKIAEDIPVFPISAVTKTGLRELLLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFEISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRAMGVDEALRKRGAKDGDIVRLLDYEFEFMD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_STAAB
Sequence: MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGKTQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHDPTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQNNKQQQIWNLIEPYIS
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PFA4_EMENI
Sequence: MLCSSFSVSRLAIPAVCILIAFLAYTSQIFFLYFEDAPLKEDEVWRINILAICIWICYYRACTVDPGHVPKGWMPSDRERLKADRASGRQRWCRRCEAYKPPRAHHCKTCERCVPKMDHHCPWTSNCVSHFTFPHFARFLFYAVVGIAYLETRLWQRVSKVWGSRHLPSYLGPSMGQIGHLFVLFVTNSLTLFALSLLLLRTLWSLGSNTTTIESWEIERHETLLRRARRLGGSLPGPGGISVHITKQEFPYDIGIWSNIRAGMGGSANVLSWFWPLARTPDRSTGLEFEENGFEDPTVSWPPPDPDRIPLPPMDQRDSFMYDITDTSGTSGQIDIEAFNRRKEADLRRRRAPTEIERRKPFHVRLEEYSNGSSDAEADTGSDDDSDHGEEGWKNSEGERLRDFGVDEEAEFYDEEDIPLALLIQQRAKRQHLSQ
What is the function of this protein?
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
What are the official names of this protein?
Palmitoyltransferase pfa4, Protein S-acyltransferase, PAT, Protein fatty acyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ARLY_HALHL
Sequence: MSQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLTEAERDAILQGLAEIRQEVVEERFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQIATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMPGFTHLQVAQPVTFGHHMLAWYEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDRDFAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELVRGKAARAQGSLVQLLTLMKGQPLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVNRERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAVRYATEADRDLAELSLEELQQFSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_SACPA
Sequence: MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLQGNAQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVAGGGDPILYEHLFYFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLATIYGGSIRLATPMLYAIAFLFLFTMGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQILGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASIGSFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYTKAPDFVESNTIFNLNTVKSSSIEFLLTSPPAVHSFNTPAVQS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZNF24_PANTR
Sequence: MSAQSVEEDSILIIPTPDEEEKILRVKLEEDPDGEEGSSIPWNHLPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPKELQTWVRDHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEDMVSQEEAQGLPSSELDAVENQLKWASWELHSLRHCDDDGRTENGALAPKQELPSAVESHEVPGTLNMGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKPYECVQCGKSYSQSSNLFRHXXRHNAXKLLNVVKV
What is the function of this protein?
Transcription factor required for myelination of differentiated oligodendrocytes.  Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state.  In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle.  Specifically binds to the 5'-TCAT-3' DNA sequence.  Has transcription repressor activity in vitro (By similarity).
What are the official names of this protein?
Zinc finger protein 24.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPB_LOTJA
Sequence: MIINPTTSDPEVSALEKKNTGRIAQIIGPVLDVTFPPGKMPNIYNALIVKGRDTVGQQINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGAALSVPVGGVTLGRIFNVLGEPIDNLGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEKNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDSLPEQAFYLVGNIDEATVKATNLEKESKLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: K1H1_MOUSE
Sequence: MPYNCCLPALSCRTSCSSRPCVPPSCHGCTLPGACNIPANVGNCNWFCEGSFNGNEKETMQFLNDRLASYMEKVRQLERENAELECRIQERNQQQDPLVCPAYQAYFRTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYETELGLRQLVESDINGLRRILDELTLCKSDLEAQVESLKEELLCLKRNHEEEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRCQYEAMVETNRREVEEWFTTQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHCMRNSLENTLTESEARYSSQLSQVQCLITNVESQLGEIRADLERQNQEYQVLLDVKARLECEINTYRGLLESEDCKLPCNPCATSNACGKPIGPCVSNPCVPCPPPAPCTPCVPRPRCGPCNSFVR
What are the official names of this protein?
Keratin, type I cuticular Ha1, HKA-1, Hair keratin, type I Ha1, Keratin-31, K31.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: L2HDH_NEMVE
Sequence: MLKTSFLLSKRNAVSLSRVLATGISGRNVRHLTLQPSEHYDVAIVGGGIVGLATARELILRHPKLTFCVLEKEKELSMHQSGHNSGVIHCGIYYTPGSLKAKLCVQGLDLTYQYCDEHNIPYKKCGKLIVAVEDKEIPLLNNLYERGKKNGVKDLTMVDKRGIKEIEPHCEGMFAIVSPNTGIVDWAQVALAYGDDFRKGGGDIFTGYEVTDFKCASESGKSQEKEAGLTHPVTVFSNNKQTIKCRYVITCGGLYSDRLAEKSGCNREPRIVPFRGDYLVLKPEKCHLVKGNIYPVPDPNFPFLGVHFTPRMDGSVWLGPNAVLAFAREGYNLLDINLRDLADALAFRGLRQLMFKYFSFGVGEYYRGLNHAAQVKQLQKYIPSVTADDVVSGPSGVRAQALDRDGNLVDDFVFDGGVGEIGSRVLHVRNAPSPAATSSLAIARMVADKAAERFTL
What are the official names of this protein?
L-2-hydroxyglutarate dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the L2HGDH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL17_DEBHA
Sequence: MVRYAATSANPAKSASARGSYLRVSYKNTRETAQAISGWKLERAQKYLDQVLDHQRAIPFRRFNSSIGRTGQGKEFGVTKARWPAKSVNFIKDLLRNGQANAESKGLDASKLKVSHIQVNQAPKQRRRTYRAHGRINAYQSSPCHIELILTEENEAVEKADDSKKVRLNVRQRGRLATQKRVTAA
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PR38A_XENTR
Sequence: MANRTVKDAHSVHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELKYVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRTLGALYMRLTGTATDCYKYLEPLYNDYRKVKVQNRNGEFELMHVDEFIDQLLHEERVCDVILPRLQKRFVLEETEQLDPRVSALEEDMDDVESSEEEEDEDEKGRDPSPEHHRRNYRDLDRPRRSPSPRYRRSRSRSPRRRSRSPKRRSPSPPRRERHRSKSPRRHRSRSRERRHRSKSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor 38A.
What is the protein family that this protein belongs to?
Belongs to the PRP38 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PALI_YARLI
Sequence: MGLRMKSATGLLVILLIAFALQLVAVLSVPVTKTISLGSYQDHKFGVFGYCNVKDGTCSPAGVGYNLVDSDNAGFSLPSNARHTLSNLLIVHPIATGFTLILTVLAMLAHIQGPASSSRYLLFCLVFSLPTFLLVLLSFLVDILLFVPHLDWGGWIVLAATILVAISGVVLCVMRRTLSSKKAMKKHQLDTTNELSAFSSHKHLNSFTYSSKENVPQFSELRYETSHDTSKDEEVLPLTSHVYEEPGHHVGDTSYASQGTNNSRVNLLTSEEPQAPKRESPFKDQRQDRYTPDRYGPSPDRYDQGGPGRPPNGSRGVPPRRPSNGPTPPGQGPSPTGAYGRNNNPNYNGGYNNRLPRPRGPPGSNNSSPFLGARNGPGLTPPHNLQTATTGPMQLPAGTYLPGEEPANSPDTYGPGVIPIPEIRRESKVPGASPTPPPVSGNSPPTETSESGVSRPYRGNYSRRGSEASAQTPPNAQPNPPPGGAQNYEYVPARQQWNLTTEESNATAPAPGPQPLQRNHSYDTYNPYRSETPSAPGSRAQSQGTDDNLGTLHQPVPTTVTPSNSGALNNKDSPWYSPPVDEQFRNSFIPDAPVSPSESISSNFTSVSQRGINPRYFGADGPPGGLHQGAPPPPHMRGPPPHMGMGGPNMGGHNMGGHNMGGPPPNMGPRPPYGGGGPGHGNKHDLLLSGNPDSQFQPQTRRKPGRGGRPGMSPASLMGRDTGPYSMR
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
pH-response regulator protein palI/RIM9.
What is the protein family that this protein belongs to?
Belongs to the palI/RIM9 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RCL1_MOUSE
Sequence: MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRRIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLEALLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKILRRGMPPGGGGEVLFSCPVRKVLKPVQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVSSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAVLPEDLGRNCAKLLLEEIYRGGCVDSTNQSLVLLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQVMFKVETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  Does not have cyclase activity (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PBP7_ECOLI
Sequence: MPKFRVSLFSLALMLAVPFAPQAVAKTAAATTASQPEIASGSAMIVDLNTNKVIYSNHPDLVRPIASISKLMTAMVVLDARLPLDEKLKVDISQTPEMKGVYSRVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKSLGMNNTRFVEPTGLSVHNVSTARDLTKLLIASKQYPLIGQLSTTREDMATFSNPTYTLPFRNTNHLVYRDNWNIQLTKTGFTNAAGHCLVMRTVINNKPVALVVMDAFGKYTHFADASRLRTWIETGKVMPVPAAALSYKKQKAAQMAAAGQTAQND
What is the function of this protein?
Cell wall formation.  May play a specialized role in remodeling the cell wall.  Specifically hydrolyzes the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi.
What are the official names of this protein?
D-alanyl-D-alanine endopeptidase, DD-endopeptidase, Penicillin-binding protein 7, PBP-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S11 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MLIC_ECOLI
Sequence: MTMKKLLIIILPVLLSGCSAFNQLVERMQTDTLEYQCDEKPLTVKLNNPRQEVSFVYDNQLLHLKQGISASGARYTDGIYVFWSKGDEATVYKRDRIVLNNCQLQNPQR
What is the function of this protein?
Specifically inhibits C-type lysozymes.
What are the official names of this protein?
Membrane-bound lysozyme inhibitor of C-type lysozyme.
What is the protein family that this protein belongs to?
Belongs to the MliC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Anchored to the periplasmic side.
Protein: ECTC_MYCGI
Sequence: MIVRTTDEITGTHRDVAAANWRSKRIVLADDAVGFSFHETTIDADSVSEFHYRHHVEAVWIVEGTGTLTNHETGEEHPLRPGTMYLLNGHERHRVTCDTTMRMLCVFNPPVTGQEIHDETGAYPPAVQAS
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: RBL_LUPPE
Sequence: SVGFKAGVKDYKLTYYTPDYKTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPNAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLASEGNQIIREASKWSPELAAACEVWKE
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS7_STUS1
Sequence: MSERTAYVERNTLETQVKVTINLDGTGKARFAIGVPFLEHMLDQIARHGLIDLDIECNGDLHIDDHHTVEDVGITLGQAFAKAIGDKKGMTRYGHAYVPLDEALSRVVIDFSGRPGLTMHVPYTRAVVGKFDVDLFQEFFQGFVNHALVTLHIDNLRGTNTHHQIETVFKAFGRALRMAIELDPRMAGQMPSTKGCL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: RL31_SYNJB
Sequence: MPKKGLHPQWYPEAKVICNGEVVMTVGSTKPELKVDVWSGNHPFFTGSQKIIDSEGRVEKFMRKYGMSGGKKAK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RPSK_BACSU
Sequence: MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELMAKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTKLATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKSMPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLIDVLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKELGISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of sporulation specific genes in the mother cell.
What are the official names of this protein?
RNA polymerase sigma-K factor, Sigma-27, Stage IV sporulation protein CB.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: PAGD_SALTY
Sequence: MKHHAFMLWSLLIFSFHVLASSGHCSGLQQASWDIFIYDFGSKTPQPPTNTDKKQARQISSPSCPTTKPMMSAPVNDARKGNTFSRT
What is the function of this protein?
Putative function in virulence.  Could be involved in promoting S. typhimurium survival within macrophages.
What are the official names of this protein?
Virulence protein PagD.
Protein: HEXI1_XENLA
Sequence: MSEVGICKSLAGGGSLLAPKEGGGWHHPVEREEHPVGDANTVSEGHDKESAYQNPGQLVKAEAQEDDWKELGKKRHRRLRSKNKRRWKPYDKLTWEEKKELEERQSQRASRIRAEMIAKGQPVAPYNTTQFLMEDHDQEEPDLCPPPRKSSAALPLALNNSSYKGDSTDDDLEEEEDEAGSDGMGGYDGEDFLQKDFSETYERYHAESLQDMSKQDLIKEYLELEKCLSRMEEENNHLRVQSLASAPAADHRDTRIQELQVELEKLKEENQRLLQEGKQVAADSP
What is the function of this protein?
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor.  Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
What are the official names of this protein?
Protein HEXIM1.
What is the protein family that this protein belongs to?
Belongs to the HEXIM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.
Protein: MK10_MOUSE
Sequence: MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death.  Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3.  In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity.  Plays regulatory roles in the signaling pathways during neuronal apoptosis.  Phosphorylates the neuronal microtubule regulator STMN2.  Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP.  Participates also in neurite growth in spiral ganglion neurons.  Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).  Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 10, MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton (By similarity). Recruited to the mitochondria in the presence of SARM1.
Protein: RS13_YERPN
Sequence: MARIAGINIPDQKHTVIALTAIFGIGKTRSQAICVAAGIAEHVKISELSEEQIEKLRDEVAKYVVEGDLRREVTLSIKRLMDLGTYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RIMK_SYNC1
Sequence: MKIGILSRNPELYSTRKLYEAAIIRGHQARIIDPLLCYMTIASQRPTIHYKGEELTGFDAIIPRIGASITFYGTAVVRQFEMMNIYSVNESVAISRSRDKLRSLQLLSRKGIGLPHTCFAHSTRYTKDLINQVGGAPLVVKLLEGTQGIGVVLAETQKAAESVIEAFKGLKEQILVQEFIEESGGADIRCLVVGGKVVAAMKRQGAEGEFRSNIHRGGKATVVRLTPEERATAVRSAHIMGLNVAGVDILQSNRGPIVMEVNSSPGLEGIETATGKDVADEIIRFIEKHTKPGRTKTRGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: HIS8_BACTN
Sequence: MKTLQELTRPNIWKLKPYSSARDEYKGAVASVFLDANENPYNLPHNRYPDPMQWELKTLLSKIKKVSPQHIFLGNGSDEAIDLVFRAFCEPEKDNVVAIDPTYGMYQVCADVNNVEYRKVLLDENFQFSAEKLLAATDERTKLIFLCSPNNPTGNDLLRSEIEKILREFEGLVILDEAYNDFSEAPSFLEELDKYPNLVVFQTFSKAWGCAAIRLGMAFASEAIIGILSKIKYPYNVNQLTQQQAIAMLHKYYEIERWIKTLKEERDYLEEEFAKLSCTVRMYPSDSNFFLAKVTDAVKIYNYLVGEGIIVRNRHSISLCCNCLRVTVGTRVENNTLLAALKKYQG
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.