PharMolix/UniProtQA huggingface dataset:
Protein: MATK_CEDDE
Sequence: MDEFHRYGKEDSSWQQCFLYPLFFQEDLYAISHDHYLDGSSSSEPMEHFSFNDQLSFLTVKRLIGRIREQNHSIGLFVNCDPNPLVDRNKSSYFESVLEGLTLVLEVPFSTRSKYSVQGIKEWKSFRSIHSIFPFLEEKFPHSNYILDTRIPYSIHPEFLVRTFRRWIQDAPSLHPLRSVLYEYRNSPENLQRSIIVAPRVNTRFFLFLWNHYVYECESILVPLLKRSFQSRSSSHGSFPERTLFDRKIKHIIRISHRNSLKSIWSLKDPKIHYVRYGERFIIAIKGTHLLVKKCRYYLPIFRQCYFHLWSEPYRVCSHQLSKNCSSFPGYSLRVRMKPLLVRTKMLGELFITDLITDEFYPIVPIVSIIGLLAREKFCDISGRPISKLAWTSLTDDDILDRFDRIWRNFFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKEREFDSPAFSSKAVARSQRERIWHSDIPQINPLANSWQKIQDLKIKNLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PER2_VOLCA
Sequence: AVTPGSIPNFPFRDCNTTNGAYRLAPVWRPSGSNTYCFKIQVSQDALSCTGACCSADLHKIEFNVCSSCLVAGASVDATVNGVRTRVGATLDKAPAGPVGSAVLRLTQLGLDTTTAQDAEVCLTLKTNRGGQGCTTLDQLCSSPGFPAGTCTAAMFDVACDCCPVSQAGQALPPPPPVIPPVLRPCDVCIAATIVPPANDVRPYRYDSATCAAIQQNIANAMNSLLGGANINVFSPFAPNASQCFDTQIITCGRFNGSDTDALANLTEAVQQQLSAFIGVASGGNVCNPKLEKYTVTVSTINNVADQCLDLSQSASCFLPGVPFPNCTCNTTQGVMPFTVSPTWYAQPANVRWGRNVTEYCFTVNTLQPSQVVPSTCYNANDALAKIEWYASDAFRSAVKGFTVYPAGGSNKTIADSWGATGTDTLKVNLNWNLLQANGGKVCVAIQNPFTMGDICKGALGQCYASIFNRDNSDYCCPIYRTGP
What is the function of this protein?
May be involved in conversion of asexual males and females to the sexual pathway.
What are the official names of this protein?
Perphorin-2, Perphorin II.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: EFTU_CLOK5
Sequence: MSKEKFERTKPHVNIGTIGHVDHGKTTLTAAITMVLAKEGKASATKYDEIDKAPEEKERGITINTAHVEYETEVRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLASRVGVQYIVVFLNKSDQVDDPELIELVEMEVRELLSEYGFPGDDVPIIVGSALKVIENPEDAEATKCIYELMEAVDTYIPTPERPVDKPFLMPIEDVFTITGRGTVATGRVESGVLKIGDEVEIVGLKEEKKKTVCTGVEMFRKLLDQAMAGDNIGALLRGIQREEIERGQVLSKPGSVKPHKKFVGQVYVLKKEEGGRHTPFFNGYRPQFYFRTTDVTGSISLPEGVEMVMPGDHIDMNVELITPVAMHEGLRFAIREGGRTVGSGVVTTVSE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R3HD2_BOVIN
Sequence: MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQIRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ
What are the official names of this protein?
R3H domain-containing protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y315_TREPA
Sequence: MVRGCRVGQRTGTVGVRVFPVGLCALSLQARDCRGMCGKRLGKVMVLGCMLPGVAARVSLSPKLGVYGDARGGSDLWGICIQAPTMPDTENQAPPRYAPETPLVGLDVAFRAENGFLLQLTVDAALTRLMFCGRCLAGYSFRPGEGSTHLSVAAGFECTALIYDSQHFLSVLGQGLLQPSSSSYSAGNWHRPRSLLGVLTCTAKEVGAIHEESAY
What are the official names of this protein?
Uncharacterized protein TP_0315.
What is the protein family that this protein belongs to?
To T.pallidum TP_0127, TP_0618 and TP_0619.
Protein: THIC2_METTH
Sequence: MTQMEEARKGNITPEMEEVARKENLDIQMLIRGIANGRIVIPSNINRESSPCGIGENLSTKINANIGSSSKMEDIELEVDKALAAVEYGADAVMDLSTGPMLRDVRKAVLEAVDVPVGTVPIYEAGVEAFMSDGAVVDMDEDDMFRAIENQARDGVDFMTVHSGITLETVERAQRSGRIMGIVSRGGAFLAAWIMQNQEENPLYSNYEYLLEVAYEYDVTLSLGDGLRPGCLADASDIPQISELLTLAELVERARDADVQCMVEGPGHMPLDQIAANMKIQKEVCDGAPFYVLGPIVTDMAPGYDHISAAIGGAVAAMNGADFLCYVTPAEHLAIPGVQDVIEGVIASRIAAQAADAARKLPGAWDSELEMADARRSFDWDKQFKLAFDSKKPYEYRMQCPIEDSEMCSMCGEYCALRILREDR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase 2, Hydroxymethylpyrimidine phosphate synthase 2, HMP-P synthase 2, HMP-phosphate synthase 2, HMPP synthase 2, Thiamine biosynthesis protein ThiC 2.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: CRCB1_DEIGD
Sequence: MKAGLWLWLMLGGAVGAVCRQGVVLALAPLVARLGFPVAVLGINVLGSFLLGLTLALAGRGVWPPEVRVAFGTGVLGAFTTFSTFSTELDELLGRGAVGLAALYAGLSVGLGLLAAVAGRLLGTRL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TTC29_RAT
Sequence: MATFPPLSMTRTKLAVLARQKLPCSSKSIPRAQLIKEKDDIDYYLEQNIKGLSKEEVAAHRNSYKKSICVDMLRDGFHKSFTELFSLMEQWDKLREAAQARSLFWLQRPLEDQPDKLDNFYHYLTKAEAAERKGYYEEVYNNLYALACYFDNSEDKWVRNHFYERCFKIAQLIKVDGGKKEAEAEAHMGLLYEEEGELLKAAEHYEAFHELTQGRLWKDATGQFLNLIACESLVRTYRLLSDRMLQNRDYKQAIKILIKASEIAREGNDRSMEGEASYYLGLAHLASGEYETALSVLDRYSEISTSLDDELSLGRAYEAMAKVLQSQGEMTEAIKYLEKFVVIARNNFKSLDVIQACTMLGDIYNEKGQYNKASDYFQQAFSTAMEVTKTTLMDETKVHYGIARAHQMMLTMNGYIESADMNSLNCLLSWKETRTQVEYDPILGEARKATEDNIYQFPDAQEETRRSPENQ
What is the function of this protein?
Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.
What are the official names of this protein?
Tetratricopeptide repeat protein 29, TPR repeat protein 29.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: OPGD_ENT38
Sequence: MNRRRFLQGSLAMAALSGTTGLSTLFSRAAFAADSDIADGQSRRFDFSVLQSMAHDLAQTPWGGAPRPLPNTLATMTPQAYNAIQYDAKQSLWNNIEDRQLDVQFFHMGMGFRRRVRMFSLDSASSQAREIHFRPELFNYNDAGVDTKQLEGQSDLGFAGFRAFKAPELARRDIVSFLGASYFRAVDDTYQYGLSARGLAIDTFTDTPEEFPDFTSFWFETVKPGDTTFTVYTLLDSPSITGAYKFVIHCEKSQVIMEVDNHLYARKDIKQLGISPMTSMFACGNNERRMCDTIHPQIHDSDRLAMWRGNGEWICRPLNNPQKLQFNAYQDKNPKGFGLLQLDRDFSHYQDIMGWYNKRPSLWVEPRNQWGKGSVGLMEIPTTGETLDNVVCFWQPEKPVKAGDELDFKYRLYWSAQPPVRSPLANVYATRTGMGGFPEGWAPGENYPKTWARRFAIDFVGGDLKAAAPKGIEPVITLSNGEARQVEILYVEPFDGYRILFDWYPTNDSTDPIDMRMFLRCQGDAISETWLYQYFPPAPDKRVYVDDRVMR
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ACTP_ESCF3
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LTOR2_HUMAN
Sequence: MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
What are the official names of this protein?
Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, MAPBP-interacting protein, Roadblock domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the GAMAD family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y2746_BURM9
Sequence: MADPQLITTAFDIPGYRIERSLGVARGIVVRSRSIVGTFGASIQTLFGGNISLYTSLCERARQDAYERMIDEARRMGGNAIVGMRYDATEIASGVTEVLCYGTAVQAVRAG
What are the official names of this protein?
UPF0145 protein BMA10229_A0446.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RDXA_HELPY
Sequence: MKFLDQEKRRQLLNERHSCKMFDSHYEFSSTELEEIAEIARLSPSSYNTQPWHFVMVTDKDLKKQIAAHSYFNEEMIKSASALMVVCSLRPSELLPHGHYMQNLYPESYKVRVIPSFAQMLGVRFNHSMQRLESYILEQCYIAVGQICMGVSLMGLDSCIIGGFDPLKVGEVLEERINKPKIACLIALGKRVAEASQKSRKSKVDAITWL
What is the function of this protein?
Reduction of a variety of nitroaromatic compounds using NADPH as source of reducing equivalents; two electrons are transferred (By similarity).  Capable of reducing metronidazole; inactive RdxA renders the bacterium resistant to this compound.  The reduction of metronidazole generates hydroxylamine, a potent mutagen and bactericide.
What are the official names of this protein?
Oxygen-insensitive NADPH nitroreductase.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
Protein: EX7S_LACLA
Sequence: MATKKEDVKFEDNLAELENIVRKLESGDVALEDAIAEFQKGMKISETLKKTLNEAEETLVKIVGKNDQESDFSPEQKDY
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CKS1_CAEBR
Sequence: MTTGSNDFYYSNKYEDDEYEYRHVHVTKDVAKLIPKNRLMSETEWRSLGIQQSPGWIHYMIHGPERHVLLFRRPLPNAQKTVRGGGGTSAVGVR
What is the function of this protein?
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.  Has a role in the exit from M phase during early mitotic cell division.  More specifically, thought to act by the degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis (By similarity).
What are the official names of this protein?
Cyclin-dependent kinases regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the CKS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPH_SALG2
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRQRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPEDVWTLNVKNEGKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADIQEAWVKEAACVGVTAGASAPDILVQNVIARLREFGGGEAVTLEGREENIVFEVPKELRVDVREVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: ZN589_HUMAN
Sequence: MWAPREQLLGWTAEALPAKDSAWPWEEKPRYLGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREKSELIKHQRIHTGDKPYVCRD
What is the function of this protein?
May play a role in hematopoietic stem/progenitor cell differentiation.  May play a role as a DNA binding-dependent transcriptional repressor.
What are the official names of this protein?
Zinc finger protein 589, Stem cell zinc finger protein 1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UQCC3_MOUSE
Sequence: MEVARKALVAVAVLGGGAGVGSILFALVTPGELQKQSMLQEMPERDSRRRDEAVRTTELVMATLKDAAATKENVAWRRNWTVSGDGRSA
What is the function of this protein?
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex.  Thereby, plays an important role in ATP production by mitochondria.  Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 3.
What is the protein family that this protein belongs to?
Belongs to the UQCC3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RLMG_SALHS
Sequence: MSHVDDGFRSLTLKRFPQTDDVNPLLAWEAADEYLLQQLDETEIRGPVLILNDTFGALSCALAEHSPYSIGDSYLSELGTRENLRHNGIAESSVTFLDSTADYPQAPGVVLIKVPKTLALLEQQLRALRKVVTAQTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFSHPQLADAPQTLNWKLEDTGWTIHNHANVFSRTGLDIGARFFMQHLPENLDGEIVDLGCGNGVIGLSLLAKNPQANVVFVDESPMAVDSSRLNVETNLPEAFERCEFMINNALSGVEPFRFNAVFCNPPFHQKHALTDNIAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCATIATNNKFVILKAVKQGRRR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHO1_CANAL
Sequence: MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAASSKQENFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNLIYNSNSAGNLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGSGSHNHNANNANNNIPIGAGNAIIGKGEMSPYDDRFAASGVNQPTSESLRLASGPQMGNGPFTTTGAIINPNLQQPLSGSIGGSAHHTPTNINNNNNNNNNTGYMTSSHLTGLENFSSPHVPGSGAGAGLGVGAGRDLTHNSNGGGGGSGGGPASANNSNNTNKRNTIYTDSETGTGITFRYKAKALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.  Mediates resistance to oxidative stress.  Controls the activation of the CEK1 MAP kinase.  Influences the molecular weight and polymer distribution of cell wall mannan.  Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C. albicans and which is known to play a major role in pathogenesis.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSAC_CAPBU
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLWHETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: NFKB1_CHICK
Sequence: MAGEDPYIMGVSDPQMFAMDQLMGMSTIFNNTGYITSDLPLRTADGPYLQIIEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKYVHLHAHSLVGKFCEDGVCTVNAGPKDMVVGFANLGILHVTKKKVFETLETRMIDACKKGYNPGLLVHPELGYLQAEGCGDRQLTEREREIIRQAAVQQTKEMDLSVVRLMFTAFLPDSNGGFTRRLDPVISDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEDENGGMWEGFGDFSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDGYGGGSGAGGGGMFGGGGGGAGSGFSYPSYGYSAFGGMHFHPGTTKSNAGMKHELSNSTVKKDEESSDKQSDKWDTKHDVKVETVEKNECRTSGHNEEKEDASLCCKDEGNKPKCGCQDGLFLEKAMQLAKRHCNALFDYAVTGDVRMLLAVQRHLTAVQDDNGDNVLHLSIIHLHRELVKNLLEVMPDMNYNNIINMRNDLYQTPLHLAVITKQAEVVEDLLKAGANVNLLDRHGNSVLHLAAAEGDDKILSLLLKHQKASSMIDLSNGEGLSAIHMVVTANSLSCLKLLIAAGVDVNAQEQKSGRTALHLAVEQENVPLAGCLLLEGDADVDSTTYDGTTPLHIAAGRGFTKLAAVLKAAGADPHVENFEPLFDVEEDVKDDDDDEGIVPGTTPLDMAANWEVYDILNGKPYIAAAAVSEDLLSQGPLRELNESSKQQLYKLLETPDPSKNWSTLAEKLGLGILNNAFRLSPSPSKTLLDNYKISGGTVQELIAALTQMDHTEAIEVIQKALSSSQRQSHQEDNTIEAFPSLSPTSFAKEETGELYNHKFQDPESTCDSGVETSFRKLSFTYSDSLNSKSSITLSKMTLGYRKAQCKAVIYLTR
What is the function of this protein?
P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.  The precursor protein itself does not bind to DNA.
What are the official names of this protein?
Nuclear factor NF-kappa-B p105 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I- kappa-B).
Protein: CEAM4_HUMAN
Sequence: MGPPSAAPRGGHRPWQGLLITASLLTFWHPPTTVQFTIEALPSSAAEGKDVLLLACNISETIQAYYWHKGKTAEGSPLIAGYITDIQANIPGAAYSGRETVYPNGSLLFQNITLEDAGSYTLRTINASYDSDQATGQLHVHQNNVPGLPVGAVAGIVTGVLVGVALVAALVCFLLLSRTGRASIQRDLREQPPPASTPGHGPSHRSTFSAPLPSPRTATPIYEELLYSDANIYCQIDHKADVVS
What is the function of this protein?
Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.
What are the official names of this protein?
Carcinoembryonic antigen-related cell adhesion molecule 4, CEA cell adhesion molecule 4, Carcinoembryonic antigen CGM7, Non-specific cross-reacting antigen W236.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DNAJ_NEIMB
Sequence: MSNQDFYATLGVARTATDDEIKKAYRKLAMKYHPDRNPDNKEAEEKFKEVQKAYETLSDKEKRAMYDQYGHAAFEGGGQGGFGGFGGFGGAQGFDFGDIFSQMFGGGSGRAQPDYQGEDVQVGIEITLEEAAKGVKKRINIPTYEACDVCNGSGAKPGTSPETCPTCKGSGTVHIQQAIFRMQQTCPTCHGAGKHIKEPCVKCRGAGRNKAVKTVEVNIPAGIDDGQRIRLSGEGGPGMHGAPAGDLYVTVRIRAHKIFQRDGLDLHCELPISFATAALGGELEVPTLDGKVKLTVPKETQTGRRMRVKGKGVKSLRSSATGDLYCHIVVETPVNLTDRQKELLEEFERISTGLENQTPRKKSFLDKLRDLFD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23A_YEAST
Sequence: MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L23-A, L17a, Large ribosomal subunit protein uL14-A, YL32.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H3_LYTPI
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3, embryonic.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.