PharMolix/UniProtQA huggingface dataset:
Protein: A4_MACFA
Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLRKTTREPLTRDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
What is the function of this protein?
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
What are the official names of this protein?
Amyloid-beta precursor protein, ABPP, APP, Alzheimer disease amyloid A4 protein homolog, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta (A4) precursor protein, Amyloid-beta A4 protein.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles. During maturation, the immature APP (N- glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions. SUBCELLULAR LOCATION: [C83]: Endoplasmic reticulum. Golgi apparatus. Early endosome. SUBCELLULAR LOCATION: [C99]: Early endosome. SUBCELLULAR LOCATION: [Soluble APP-beta]: Secreted. SUBCELLULAR LOCATION: [Amyloid-beta protein 42]: Cell surface. Note=Associates with FPR2 at the cell surface and the complex is then rapidly internalized. SUBCELLULAR LOCATION: [Gamma-secretase C-terminal fragment 59]: Nucleus. Cytoplasm. Note=Located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). In dopaminergic neurons, the phosphorylated Thr-743 form is localized to the nucleus (By similarity).
Protein: ATPB_LACJO
Sequence: MSKGEIVQVIGPVVDVEFPLDKDLPDINNALRVTNNNGDTLVLEVTLELGDGVLRTISMESTDGLRRGMEVEDTGAPISVPVGKDTLGRVFNVLGDPIDGGPALGKDVKREGIHKEAPKYDELSTSEEILETGIKVIDLLEPYVRGGKVGLFGGAGVGKTTIIQELIHNIAQEHGGISVFTGVGERTREGNDLYFEMKASGVLSKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGLDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSITSIQAVYVPADDYTDPAPATTFAHLDATTNLERRLVEQGIYPAVDPLESTSSALDPEIVGEEHYEVAVKVQHILQRYQELQDIISVLGMDELSDDEKLIVERARKIQFFLSQNFFVAEQFTGIPGSYVPIKETIKGFKMIIDGKLDDLPEDAFRNVGPIEDVIKQAEKMGVTPKNPEAKAILEAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YJDJ_ECOLI
Sequence: MEIREGHNKFYINDKQGKQIAEIVFVPTGENLAIIEHTDVDESLKGQGIGKQLVAKVVEKMRREKRKIIPLCPFAKHEFDKTREYDDIRS
What are the official names of this protein?
Uncharacterized protein YjdJ.
Protein: MSCL_LISMF
Sequence: MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVDNIIMPLVGVLLGGLDFTDLSFKVGKSVIQYGAFIQSIVDFVIIAFAIFIFVKVLTSFIKKKEQTVEETPVPPTEEYLKEIRDLLKEQQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RF1_FRATM
Sequence: MKDSIKAKLQSLIERHEEVSALLSEAGIISDQNKFRDLSKEYSHLEPIVKAFKEYTQALEDKQAAYEMLNEKDAELVEMAKEELKLANEAIEKLESELQIFLLPRDPNDDANVFLEIRAGTGGDEASIFSGDLFKMYSKYAEQRGWKIEVISASEGEHGGYKEIISRIYGDGVYSQLKFESGAHRVQRVPATESQGRIHTSACTVAVMPEADEVEGIDINPADIKVDTFRASGAGGQHVNKTDSAIRITHIPTGVVVECQDQRSQHKNRAAAMSMLKSKLLQAEIDKQQKEQSDTRKSLVGSGDRSERIRTYNYPQGRVTDHRINLTLYKLDEVMEGSLDSIIQPLILEHQADLLATMSDE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_BORBU
Sequence: MLKSNKVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNINVLFGTYKDCANADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVASNPVDIMTYVTMKYSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEHGDSSFATWDETKIAMKPLSEYLAEGKITELELDEIHKKVVNAAYEVIKLKGATYYAIGLGIKNIVNAIIGDQNVILPISSYINGQYGGLIKDIYIGAPAIVCKEGVKEVLNFKISPKELDKFNSSANQLKSYIDKMEF
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX812_LYCSI
Sequence: MKLIIFTGLVLFAIVSLIEAQAENEKACLPQYQVCTDAPGNCSSNLVCDCYGRYKSGARIGRNCFCLQKGVIYKREN
What are the official names of this protein?
U8-lycotoxin-Ls1c, Toxin-like structure LSTX-H12.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 08 (U8-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VP30_MABVM
Sequence: MQQPRGRSRTRNHQVTPTIYHETQLPSKPHYTNYHPRARSMSSTRSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCADPTCNRDHDLDNLTNRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHMNHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQSQGKGQ
What is the function of this protein?
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation.  This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).
What are the official names of this protein?
Transcriptional activator VP30, Minor nucleoprotein VP30.
What is the protein family that this protein belongs to?
Belongs to the filoviridae transcriptional activator VP30 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Tightly bound in the nucleocapsid.
Protein: ARSA1_AQUAE
Sequence: MRIILFSGKGGVGKTTISAATGYKLSQLGKKVIVVSLDPAHSLADSFDVPEEERRKAKGLPIKINENLEIQEIDIQEEIERYWGEVYRFIELLFHTTGLHEILADELAILPGMEEITSLLYVNKYYREGNHDVLILDLPPTGESIRFVSMPTVMKWYMKKIFKTERLIMKVARPTVGRMTDVPLPDEEYFKALETFYERLKGVDEILINPDITSIRIVSNPEKMVLKESQRAFLYFLLFGVNVDAVIVNKVIPEEVIQQENCSFLEKWLNIQKKYVKEIESYFSPVPVFKVPLLEEEVVGLERLEKLAQLIYGDEPPDKIFHKEIPYKIEQLDGKYVIRIKAPGVKKESISLVKGEDEIVVRVGNFKAHVMLPRKLRNLEPERAKVEKDEILIFMS
What is the function of this protein?
Anion-transporting ATPase.  Catalyzes the extrusion of arsenite (By similarity).
What are the official names of this protein?
Putative arsenical pump-driving ATPase 1, Arsenical resistance ATPase 1, Arsenite-translocating ATPase 1, Arsenite-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
Protein: BSHC_BACAC
Sequence: MEIKEISVPQQGVVADYMNGKKEIQSCFDYMLTEDAFKQRVQDLREREFFRQDLVTHLLEYNTKLQAGEATIQNVKALGDENTYVVIAGQQAGLLTGPLYTIHKIISVLQLAKEKEESLGVKVVPVFWIAGEDHDMDEINHTFVTKNKKIKKTIFHDRNPKKASASESELSLEDCRKWIEEIFKTYPETNFTKDVLQFIDDSLRKSNTYVDFFGHLIMKMFVNSGLILVDSHHPELRKLEVPFFKQIVSKYKEVQEGLHNQQRVIKELGYKPIIETKSNAVHIFMEIDNERVLLEDNQGKFVGKDGTYSFSYKELIEEMERSPERFSNNVVTRPLMQEYVFPTLAFIGGPGELAYWSELQQVFHTIGFRMPPVVPRITITYIERDIATDLHDLQLQESDPFFNNVDKLRENWLSNQIEEPIDERFVEAKKEIIDIHKSLQQFVKKIDPGLSAFAGKNEFKINEQIELLERMLKRNVEKKHEVELNKFRRIQFALRPLGAPQERVWNVCYYLNQFGLDFVDRVMEKPFSWNGKHHVIKL
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: PPE16_MYCTO
Sequence: MSFLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAELGQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAVAQAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASAVAAQLAPWAQAVRALPNPTAPALASGPAALAIPALGIGNTGIGNIFSIGNIGDYNLGNGNTGNANLGSGNTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLGNIGDGNRGSGNVGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIANLGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNNIGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGDLNSGDFNTGWANSGDINTGGFHSGDLNTGFGSPVDQPVMNSGFGNIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG
What are the official names of this protein?
Uncharacterized PPE family protein PPE16.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: VKT_AUSLA
Sequence: MTREKSLALLITLAAALAAAESPPGRCHSPKTVGPCRASFHRWRYNATSQMCQEFIFGGCKGNANNFVSKQDCFQTCIRGGAAEATVVPSGPATEVATPRAGHLPEAYENRPGFREFCAAPRVVGPCRASFLRWYFDLESRMCKMFIYGGCRGNKNNYLFEEHCWSQCTGDGEITEEPGDAGAQPPLPSEPFSFSTRAVVLAVLPAILVTILLGSMGVFFVKICRKNPELSVGTVWSTLDDKEYLMSNAYTL
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Putative Kunitz-type serine protease inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: EZRI_HUMAN
Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
What is the function of this protein?
Probably involved in connections of major cytoskeletal structures to the plasma membrane.  In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.  Along with PLEKHG6, required for normal macropinocytosis.
What are the official names of this protein?
Ezrin, Cytovillin, Villin-2, p81.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
Protein: THI4_DESOH
Sequence: MELNEVTISRAIIDRFYEKLIANLEVDVAVVGGGPSGLVAAWRLARAGRKVALFERKLSIGGGMWGGAMLFNEIVVQKSALHVLDAMEIGYRLYAEDYYTADAVEAISTLTSQAAKAGVAIFNCVTVEDVMIRPDRIVGLVLNWSPVEMAGLHVDPLAMRASFVIDATGHATEVVHVVAKKVPGTLRTDSGKIEGEKSMWSDRAESLTLENTREVYPGLYVAGMAGNATFGGPRMGAIFGGMLLSGEKVAAEILERLE
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: MCRG_METBF
Sequence: MAYERQYYPGATSVAANRRKHMSGKLEKLREISDEDLTAVLGHRAPGSDYPSTHPPLAEMGEPACSTRENVAATPGAAAGDRVRYIQFADSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQIVEARERDMEQCAKVQMETEITDHALAGVRGATVHGHSVRLQEDGVMFDMLDRRRLENGTIIMDKDQVAIPLDRKVDLGKPMSSEEAAKRTTIYRVDNVAFRDDAEVVEWVHRIFDQRTKFGFQPK
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase subunit gamma, Coenzyme-B sulfoethylthiotransferase gamma.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_HAEIG
Sequence: MLISNTYNQHFPQLTQEQIASNATKKVICGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDDDTDYCTAAADLADAQAVCDKLGIKLHKINFAAEYWDNVFEHFLTEYKAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRAGDNENAKLLRGLDANKDQSYFLYTLSHKQVGQSLFPVGEIEKPIVRAIAEDLGLITAKKKDSTGICFIGERKFKDFLARYLPAQPGNIRTVDDEIIGRHDGLMYHTLGQRKGLGIGGLKNAGDEAWYVVDKDVENNELIVAQGHDHPRLFSKGLIASQLHWVDREPIRESLRCTVKTRYRQQDIPCVIEPIDDETIRVIFDEPQSAVTPGQSAVFYLGEVCLGGGIIAERI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ACIC1
Sequence: MRAQPDLKPRSRDVTDGLERAAARGMLRAVGMTDADWEKPQIGVASSWNEITPCNLSLDRLAQAAKEGVHAAGGYPLEFATISVSDGISMGHEGMHFSLISREVIADSVETVFMAERFDGAVLLAGCDKSEPGMLMAAARLDLAAVFLYAGSTLPGKLGDRDINIVDAFEAVGGCLRGLVSREEVDAIERNFCPVEGACAGMFTANTMASAAEALGMSLPGSASPPAPDRRRDGFARASGEAVVNLLRRGITARDIMTREAFENAIAVVMALGGSTNAVLHLLAIAREANVDLAIDDFNRIGDRVPHLADVKPFGRYVMSDVDRVGGVPVVMKALLDAGLLHGDCLTVTGKTVAENLADITPPDPDGKVIHALTQPIHRTGGLAILRGSLAPDGAVVKTAGLESTFFEGTARVFDGEEAAMRAVPELRPGDVVVIRYEGPKGGPGMREMLAVTGAIKGAGLGKDVLLVTDGRFSGGTTGFCVAHVAPEAVDGGPIAFVRDGDRIRLDAQARTLDLLVDADELAKRRADWQPPPPRYTTGVAAKYVKLVGSASEGAICR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PA21B_HORSE
Sequence: ENGISPRAVWQFRSMIQCTIPNSKPYLEFNDYGCYCGLGGSGTPVDELDACCQVHDNCYTQAKELSSCRFLVDNPYTESYKFSCSGTEVTCSDKNNACEAFICNCDRNAAICFSKAPYNPENKNLDSKRKCA
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract.  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines.  May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract.  Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).  May act in an autocrine and paracrine manner (By similarity).  Has anti-helminth activity in a process regulated by gut microbiota.  Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
What are the official names of this protein?
Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
Protein: VE6_HPV26
Sequence: MFEDPRERPRTLHELCESLNTTLQNLQVQCVYCKETLQWADVYNFAICDLRVVYRDRSPYAACKRCVIFYSKITEYRRYTCSVYGATLEALTKKSLCNLLIRCHRCQMPLGPEEKQRIVDEKRRFHEIAGQWKGLCTNCWRPRRQTETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: DN7C_ACIHW
Sequence: MATKVKFKYKGEEKEVDISKIKKVWRVGKMISFTYDDNGKTGRGAVSEKDAPKELLEKLK
What is the function of this protein?
Can constrain negative DNA supercoils.  May be involved in maintaining the integrity of the genome at high temperature.
What are the official names of this protein?
DNA-binding protein 7c, 7 kDa DNA-binding protein c, Aho7c.
What is the protein family that this protein belongs to?
Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDLC_MACFA
Sequence: MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQLPKTKLPSAPCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK
What is the function of this protein?
May play a dynamic role in flagellar motility.
What are the official names of this protein?
Axonemal dynein light intermediate polypeptide 1, Inner dynein arm light chain, axonemal.
What is the protein family that this protein belongs to?
Belongs to the inner dynein arm light chain family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cell projection, cilium, flagellum. Dynein axonemal particle. Cytoplasm.
Protein: PURT_FRAT1
Sequence: MNISNIKIMLLGSGELGKEFIIAAQRLGIHTIVVDRYKNAPAMQVAHESYVIDMLNSDALEQLILAKNPTYIVPEIEAINTDSLVKLEAHNFNIIPCAKAAKLTMDRQGIRALAAQQLNLQTSKFAFANSEQEYLDVIQSIGLPFVIKPVMSSSGKGQSIVKEHNEIKKAWDYAQNGSRGHAKGVIVEQFIDFDYEITLLTVRHKDGTSFCDPIGHIQKDGDYRFSWQPHTMPDTALAKSQEIAKEITDALGGYGVFGVELFIKGDEVFFNEVSPRPHDTGMVTLISQNINEFELHLRAIVGLPIPDIQTLQPSASAAILLEGDTANASICGIDKALADANVDIRIFGKKEIHGKRRMGVVLAKAQNTHIALETSKQALAHIHLTK
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: RL14_XANAC
Sequence: MIQMQSYLDVADNSGAKEVMCIKVLGGSKRRYAHIGDIIKVTVKDAIPRGKVKKGEVYDAVVVRTRKGVRRPDGSLIRFDGNAAVLLNNKQEPIGTRIFGPVTRELRSEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: EXG1_WICAO
Sequence: MLFNILILSALSLQLCTCFHIKRNLNGSNDVIWDYYDDSKKVQGVSLGGWFVLEPYITPSLFEQFGEDEKKIPVDEYTFTEQLGKDEAQKQLDKHWATYFTESDFKDIKDYGLNLVRIPIGYWAFYLLEDDPYVQGQEPYLDKALEWAKQNDLKVWIDLHGVPGSQNGFDNSGKRGNVTWQDDEENIELSYKTLNYIFGKYGGENLTDTVIGIEIVNEPFHSKLNETDMLDFYYNSYYDFRIKHNSRNFFLIQEAFEPIGFWNTHLNNDYTNVSKPFLNDELLEEGVPKNYFHDIVLDHHHYEVFSVDQLDKSENARIQDIKNYGESVAKEQEYHPSLVGEWSGAITDCAKWLNGVGTGARYDGTFDESQLVRTNAINGTAESQFKFKDKKRSCENVTFVEDFSKQHKENIRKFIEIQLLTYENSNSGWIFWNYKTENAIEWDFKKLVEHKLFPHPFNEYKYFYENGTQIVESAASGNPQNLLFITLSALLVSLSTLL
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  It could also function biosynthetically as a transglycosylase (By similarity).
What are the official names of this protein?
Glucan 1,3-beta-glucosidase 1, Exo-1,3-beta-glucanase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.