PharMolix/UniProtQA huggingface dataset:
Protein: LST2_XENTR
Sequence: MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKDPQRCTLLVNQFRSCQDNVLNIINQIMEECIAHERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDLTRSLEEVRNLIRDQALRDLNIYTEKMKESLRHFDVLFAEFELSYVSAMVPVKSPKEYYVQQEVIVLFCETVERALKLGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYAEGPLNLERKPEDMSELFRPFHTLLRKIRDLLQTLTEDELHTLERNLCISQDVEFPANADPEVPSAISPVLVTALPTEEPPMAKAENTEVELACSMQYDEQELEQLNMMVHRVGDEMSSLLSPPSVYQSPAHRANTSNEASPCRRALDNLTDEEDRVFFMEDLDGSGEVLARSRPSETTISWVNNSCYNAKQPALYQDSVLQNGDLADVVSVKDGQRDISNNNNIDGSKMLAASASLQNSCSCLEAPESQLYLNGWDTNGEDAETAEIIAHRTGGMKISATVIFNPKSLTNSPETSPNLASNRIPSSSDPLTSNEEDESHKLSIAATNCLINSCVCCGSCEDTREDSLEGLRNVPSSGKVINASYSLIKSKELGHLDRSDCTVSAKELLKMDSPTVLLAEKETTRQEQPYPNSSKCLPLNSGSQVEMDSESDEPLTASRDQLRSESNRQETGNKERPSEEVEEPPSDRASADNITSSSSSQDGLRDSALSSISSSDYESVSVTTCSLSSIDSLSSCSSDDIDQEEIQLALQAAKIASRQKIRSRFHSSNDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKQETDDKGKQKKANQGLRSAALEDCALCQETITSSELAAKARDGEFEDPPDWVPDEVCSLCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQMKPVRVCTHCYMFHVTPFYSDRAGM
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.  Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
What are the official names of this protein?
Lateral signaling target protein 2 homolog, Zinc finger FYVE domain-containing protein 28.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated (By similarity).
Protein: ACCA_ECOLI
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_HALHL
Sequence: MSKIPLTIRGAEKLREELHRLKHEDRPRVIQAIAEAREHGDLKENAEYHAAREQQSFIEGRIQEIEGKLSNAQIIDPAAVQAAPKIVFGATVALEDTDTEETVTYQIVGEDEADIKQHLISVNSPIARALIGKEEGDEAVVQAPGGERTYEIVEVRYE
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: XPO6_HUMAN
Sequence: MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL
What is the function of this protein?
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
What are the official names of this protein?
Exportin-6, Exp6, Ran-binding protein 20.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: FTNB_ECO57
Sequence: MATAGMLLKLNSQMNREFYASNLYLHLSNWCSEQSLNGTATFLRAQAQSNVTQMMRMFNFMKSVGATPIVKAIDVPGEKLNSLEELFQKTMEEYEQRSSTLAQLADEAKELNDDSTVNFLRDLEKEQQHDGLLLQTILDEVRSAKLAGMCPVQTDQHVLNVVSHQLH
What are the official names of this protein?
Bacterial non-heme ferritin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ferritin family. Prokaryotic subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD5_MOUSE
Sequence: MAAQAVSLLREVARLEAPLEELRALQSVVQAVPLHELREQAAELRLRPLFSLLNQNNREQTALCVSILERLLQAVEPIHLARNLRLDLQRGLTHPDDSVKTLTLSQIGRIVENSEAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKNVMKTNDVVRYRVYELIIDISSVSSESLNYCTTSGLVTQLLKELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFEMADSQDPTMIGVAVDTVGILGSSVEGKQVLQKTGTRFERVLMRVGYQAKNASTELKIRCLDAVSSLLYLSPEQQTDDFLGMTESWFSSMSRDSLELFRGISNQPFPELHCAALKVFTAIADQPWAQRLMFNSPGFVEFVMDRSVEHDKASKDAKYELVKALANSKTVAEIFGNSNYLRLRAYLSEGPYYVKPVATTAVEGAD
What is the function of this protein?
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC).  In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 5, 26S protease subunit S5 basic, 26S proteasome subunit S5B.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S5B/HSM3 family.
Protein: NDK_NITSB
Sequence: MERTLSIIKPDAVAKNVIGKIIDRFETNGLRIAAMKKIQLSKNDAAKFYEVHKERPFFNDLVDYMTSGPVVVMVLEGENAVAKNRELMGATDPKEAKPGTIRADFAESIEANAVHGSDSLENAQKEIAFFFAQREIL
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_CLOB8
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVKKAEEAYNFVKQVAEEGKDILFVGTKKQAQEAIQEEAIRSNMHFVNNRWLGGMLTNFSTIRGRIRKLEQIEKMQEDGTFDVLPKKEVIKLKGEMEKLEKNLGGIRNLDASNVGAMFIVDPRKEKNAILEAKILGIPVVAIVDTNCDPEEVDYVIPGNDDAIRAVKLITAKMADAIMEGRQGEQLAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: GLMM_SHEDO
Sequence: MKQRQFFGTDGIRGKVGAGKMTPELALKLGWAAGRVLSRTGTKKVIIGKDTRISGYLFESALEAGLSAAGLNVLLVGPMPTPAVAYLTRTFRAEAGIVISASHNPYYDNGIKFFSTDGSKLDDAIELEIEAELEKPLTCVESHLLGKAKRIDDAAGRYIEYCKGNFPADQTLEGLKIVVDCAHGATYHIAPSVFSELGAEVIAIGDKPNGTNINHEVGATSMGKICETVLAEGADLGIALDGDGDRIMMVNRKGEVIDGDQILYILAADAQKRGQLKGGVVGTLMSNLGLDLALQALDIPFLRSNVGDRYVMEMLKKNDWRIGGENSGHILDLDHGTTGDGIVAGILVLAAMRRQNATLEQLVEPMKMLPQVLINVRFEGSNNPLDSDLVKSAQREVEQSLGARGRVLLRKSGTEPLIRVMVEGDDHDLVLAHANRIAAAVKLGC
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ARGJ_CHLCH
Sequence: MLTTLNKALDTIHRLAAETVWSEGVTPMKIGDSGEFGFWPKGFSVGATAGNIRYSGRDDMMLIVSDSPASAAALFTTNLCCAAPVVLSRNHLQQSAASMRAIVCNSGNANAATGKQGMADAQAMADAVAEQLSIKPEEVLVASTGVIGQLLPMERVHAGIVALPATLQSNSVLGAVSAIMTTDTFPKFYAVDVALSSGTVRLCGIAKGSGMICPNMATMLGFLATDAAIAPELLQTLLSEANRKSFNAITVDGDTSTNDMVAMLASGAGAEVVAGSKDEALFSAALQSLMILLAKLIVIDGEGATKLVEITVKGAVSNEEAELAARTIANSSLVKTAIHGEDANWGRIIAAAGRSGARFNEDELELWFNEMPILKKGLIADFSEDEAAIILAQPSYSITLSLGNGSGSATLWSCDLSKEYVEINGSYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1658_METJA
Sequence: MKDKILKDREEIEKFFIKLLGREIFISEMDIFASRCGCVGIMITVRGLFVDDVEIFKEKILNKLEELAKSYDINADWIFVRVLPGSDDIINIGVREFCNICREEYRFKKPRPDLISLKF
What are the official names of this protein?
Uncharacterized protein MJ1658.
Protein: BCHI_CHLP8
Sequence: MAFPFTSIVGQEEMKLSLILNIIDPRIGGVLVMGHRGTGKSTTVRALAEVLPLIDRVKGDIYNRTVEQYIEMESGVKGAPVLKASDVKTEKIPVPVVDLPLGATEDRVCGTIDIEKALTSGVKAFEPGLLAQANRGFLYIDEVNLLDDHLVDVLLDVAASGKNVVEREGISIRHPARFVLVGSGNPEEGELRPQLLDRFGLHARIITINDVAKRVEIVKLRREYDENPEAFLKKVVRQQQKLQKEIVAAQKLLPKVSMDDSVLTDIARLCMALGIDGHRGELTITRTAHAFAALQGDTNVTMEHVRKIAGLCLRHRLRKDPLETVDAGEKIDRELAKVLGEAEVAA
What is the function of this protein?
Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
What are the official names of this protein?
Magnesium-chelatase 38 kDa subunit, Mg-protoporphyrin IX chelatase.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
Protein: PTH_STRPI
Sequence: MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSVDKVDDSVNYYLQEKNFEKTMQRYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_YERPY
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERRQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKNMDLEAECEILREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERIYRAGLASLHARVKVRITEEIRNTEGESITRTSIIDTTVGRAILWMIVPQGLPYSIVNQPLGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEAKAGIIEEAETEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMDNLSVEDVVNRDGVVEQQVSFNSIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHNGIVMTPVIEGGDVKEPLRDRVLGRVTAEEVIKPGSADILVPRNTLLDEKWCDLLEENSVDSVKVRSVVSCETDFGVCANCYGRDLARGHIINKGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSLKLSNVKFVTNAAGKLVITSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGAEVQGGETVANWDPHIMPVVTEVSGFIRFADMVDGQTITRQTDELTGLSSLVVLDSAERTGSGKDLRPALKIVDAKGNDVLIPGTDMPAQYFLPGKAIVQLEDGIQIGAGDTLARIPQESSGTKDITGGLPRVADLFEARRPKEPAILAEISGIISFGKETKGKRRLVISPLDGSDAYEEMIPKWRQLNVFEGEVVERGDVVSDGPESPHDILRLRGVHAVTRYITNEVQEVYRLQGVKINDKHIEVIVRQMLRKGTIVDAGSTDFLEGEQAEMSRVKIANRKLAAEGKIEATFTRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRKAQGEAPVVPQVSADEATANLAELLNAGFGNNKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DCLK1_RAT
Sequence: MLELIEVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTSLSSTKVCSSMDENDGPGEEESDEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRGRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
What is the function of this protein?
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain.  May also participate in functions of the mature nervous system (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase DCLK1, Calcium/calmodulin-dependent protein kinase type I-like CPG16, Doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: FADA_VIBVY
Sequence: MKNVVIVDCLRTPMGRSKGGAFRHTRAEDLSAHLMKGILARNPQVNPSEIEDIYWGCVQQTLEQGFNVARNAALLAGLPIEIGAVTVNRLCGSSMQALHDGARAIMTGDAEICLIGGVEHMGHVPMNHGVDFHPGMSKHVAKAAGMMGLTAEMLGKLHGISREQQDEFAARSHARAHAATLEGRFKNEILPTEGHAADGTLFTLDHDEVIRPETTVEGLSQLRPVFDPANGTVTAGTSSALSDGASAMLIMSEEKANELGVTIRARIKGMAIAGCDPSIMGYGPVPATQKALKRAGLSIEDMDVIELNEAFAAQSLPCAKDLGLLDVMDEKVNLNGGAIALGHPLGCSGARISTTLINLMEAKDAKYGLATMCIGLGQGIATVFERP
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPOT_ASPOR
Sequence: MEEQVANAIEIAWNPSSDQALKAQAFDYLNQLRTDPSGWQVCLALFTKTPQHSEIIRHVALEVVNSAAQAGLIDPQALGYVRDGLMNYLRQVYGQENANPDPPNIQNKIAQTITFLFSALYGSGWESFFDDLLSLTYKGASSTSPDNMLGIVFYLRVVNSIHDEIGDVLVSRSRTEQDRANSLKDLIRMRDMQKIASSWQQILSEWRDGNDLIVEMCLKAVGSWVGWIDISLVVNQTMLDLLFQQLARAQKAELRAGEEKVRDAAVDVFTEIIGKKMKPEDKIDMIIFLNLDTIVSQLSNSPPLCENRFTFKYDTDLAETVAKLVNSTVVDIVRALEQENISAECREKANGLLQAFLPHILRYFSDEYDEVCSTVIPCGSDLLQYLRKVSKTDPSLTAQHSPILLPILKAIIAKMRYDETSSWGDEDDQTDEAEFQELRKRLAIMQQTVASVNEQLYIDAVSEVVATTFENLRQSGAQLDWRDLDLALHEMFLFGDIAVKAGSLYTKNQPNNQAAERLIEMMSRMVESDIRSFTHPATQLQYMEICVRYSSFFLYHTNLIPGVLESFLQLVHHPTKKVKTRSWYLFQRLVKQLRSHIGNVAQTVVQALGDLLVIQAEIPTEGADGDEMSSEDHEGSADAVFNSQLYLFEAVGIICSTPTVAADKQVLYVQSVLNPVFMDMEKNLAPAKSNDERALLQIHHDIMALGTLAKGFSDWMPGTSSPTSLPAPEVSEAFLQVSEATLVALESLKTSFNIRTAARFAFSRLIGVLGSRILPQLPRWIDGLLTQTSTRDEMALFLRLLDQVIFGFKGEIYAILDTLLTPFLQRVFAGIADPTTGTDDEIQLAELKREYLNFLLAVLNNDLGAVIISERNQPMFDTVITTIEHFAKDIEDFTTAKMAFSVLSKMGSSWGGPDIAPEATNGASQQVALPGFAQFMISRMSPLCWALPATPSFNPKDAQAKQVLAEAGGLQRTIYCKTGMEYIQYLRDQELPGMGMGGELIEEFLNALGQLDLKGFRQFFPVCTAR
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: CXD4_MOUSE
Sequence: MEKLNLLGFLIITLNCNVTIMGMIWLIVEVLLRMLVVVLAGSPIYEDEQERFICNTLQPGCANVCYDLFSPVSPLRFWLVQSLALLLPSVVFGTYTLHRGAKLAAVGGACRPQVPDLSTAYLVHLLLRMLLEAGLAFLHYFLFGFSVPARVSCSHVPCSGAVDCYVSRPTEKSLLILFFWAVSALSFLLSLADLLWILPRRKTLRTTQWVNGEARPVCEVPAPPPCLLQNPQGYLSQGQVDQEDRQEEQVVPEFPCMWTAGQSDNSNVGQACVSGLLEHSDQDASEATSSAGDRLTVAHTAHELRFHRETSLDLGGKNTQADELSLATQSHLARHSSASKPQAPCRLTTSGSAPHLRTKKSEWV
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction delta-4 protein, Connexin-39, Cx39.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Delta-type subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: CLIP3_HUMAN
Sequence: MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS
What is the function of this protein?
Functions as a cytoplasmic linker protein.  Involved in TGN-endosome dynamics.  May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
What are the official names of this protein?
CAP-Gly domain-containing linker protein 3, Cytoplasmic linker protein 170-related 59 kDa protein, CLIP-170-related 59 kDa protein, CLIPR-59.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Protein: HIMF_ASPJA
Sequence: MQIITIFGATGNQGSSVARSLLRNRSFEVRCITRNAESKKAQLLKAQGAVIVEADGYDTSQIQQAFSGSWGAFVNTNGDDPSLASENRTDRDLGLSIIRGAAAAGVKHLVYSSGPWAAKLSGGACSVPSNDAKAEVQHVAQGLGFETVTPIMPGWFFETFLEPQMAAIFGGFPVTPDEEGWLTCRAPLWGGREHVPFLSVDNDFGDIVHGVFLNPVRWNLRPIQAISDFLSFADFVNTYVSLTGKKARFVALSSPMEMETMGHPLLESIRGFFIFSQLRDGEYFGTGPTEKETATALKQAAHRAQANDRKGEQAALTSARDFLQARFGNSK
What is the function of this protein?
NmrA-like family domain-containing oxidoreductase; part of the him gene cluster that mediates the biosynthesis of himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor (PubMed:29314577).  First, himA, together with the trans-enoyl reductase himH, catalyzes the formation of apolyketide chain, which is then condensed with leucine by the NRPS activity of himA.  Dieckmann cyclization and release from himA gives a tetramic acid intermediate as the product of himA PKS-NRPS (PubMed:29314577).  HimG then catalyzes alpha-oxidation of the tetramic acid ring, with a subsequent rearrangement to yield apyrone intermediate (Probable).  Two terminal methyl groups of polyketide and amide side chains are oxidized to carboxylic acids by himC cytochrome P450 monooxygenase to form himeic acid A (Probable).  Himeic acid A is further converted to himeic acid B and C during culture growth.  No gene responsible for pyrone to pyridone conversion was found in the him gene cluster and himeic acid A is non-enzymatically converted to himeic acid C by the incorporation of an ammonium nitrogen atom in a pH5 buffer, and to himeic acid B at a conversion ratio of 50% during incubation in MeOH for 5 days (PubMed:29486950).
What are the official names of this protein?
NmrA-like family domain-containing oxidoreductase himF, Himeic acid A biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: DOF5_ORYSJ
Sequence: MLSHVEMAPAAGGFKLFGKVIMQCGVSEGTQDKAQGFVVAREKVEPEEEEEEEQRVPAAATSGQRASIKREAADRDEEQRQGGGDAAGQPTQRRLQDSAEARAAAAAPLPCPRCRSRDTKFCYFNNYNVNQPRHFCKACHRYWTAGGALRNVPVGAGRRKNRPLGPLAVAHHNHHHRAAAGFVLGFPNPSSPTSPSPVYTDRWPVTPDRPF
What is the function of this protein?
Transcription factor that may transactivate seed storage protein genes in developing seeds.
What are the official names of this protein?
Dof zinc finger protein 5, OsDof5.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSRA_HALOH
Sequence: MLILTRKKDEAIIIDDKIKVKVVEIDGNKIKLGIEAPDDVTIHREEVLKEILKENKQALKQKRVLNRDYTSRIKEFIAKKG
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2366_BACAA
Sequence: MKKTFYHYMMKHRAALFSNEISNLAEAMYDDLSFPKQSEDYDEISSYLELSGMLESMSIFDEAWDLYIQDR
What are the official names of this protein?
UPF0346 protein BAA_2366.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: VE2_BPV4
Sequence: MYLCLESLQKSEFANQRWSLVDTSIETFKAPPENTLKKRGQHVTVIYDQNAMNSMVYTLWKEVYYVDETETWHKTSSDLDYDGIFYIDNQGNKIYYVNFQDDAALYSNSGMGQVHFESKVLSPSVTSSLRVGSTGGQRGTQTGDHARGRSRPSPRSSRDARGRQQRAQSSSRSRSRSRSRSPTKGPHSSGRDTRLPSPGRPPGGRRRGTPERERCPGTPTPPTPDQVGGRSSTPKRQASSRLAQLIDAAYDPPVLLLQGAANTLKCFRRRATQAHPHKFLCMSTSWTWVSKTSPLKSGHRMLIAFSNSEQRNCFLASVRLPKGVSAVKGALDGL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.