PharMolix/UniProtQA huggingface dataset:
Protein: P5CR_METSM
Sequence: MNLGIIGYGNIGELLSQNIISHDFCNLNKLYIANRTLSKINHLKDIDPRISITDDNIEVAKTCEKIIISVKTPDLAIVLDPLKPHITKNQQIIHTCAGTDLEFKDCGLSCVIPTISSTYDEDNPKKGVSIIMHDENVSGENREFVEKLFSKFSQIKVVDSPMDLEIATIAASCMPAFIALGVDLFAGELEEKCNLSKEETFKILAETLNSTAYILKEDIYSPDELINKVATKNGITQKGLDVLDKRPARYL
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDI_ERWT9
Sequence: MATLVYFSSLSENTHRFIVRLNLPARRIPLDSSQQLQVSEPYILVVPSYGGGTRHGAVPKQVIQFLNDINNRQLIRGVIAAGNRNFGEAFCLAGDIIARKCHVPYLYRFELMGTSDDIANIYKGVTEFWQRQTAHS
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: RAF1_PONAB
Sequence: MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
What is the function of this protein?
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation.  RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).  The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'.  Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation.  Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity.  Phosphorylates TNNT2/cardiac muscle troponin T.  Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1).  Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death.  Regulates Rho signaling and migration, and is required for normal wound healing.  Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN.  Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity).
What are the official names of this protein?
RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Protein: GRPE_YERPB
Sequence: MSSKEQKTPNEQVSEEMENTAEQQVEATQETGECVDPRVAELEVQLSDALQRERESLLRAKAEVENIRRRTELDVEKAHKFALERFSSELLPVIDNLERALDTADKTNTELTSMIEGVELTLKSLLDAVGKFGIEVVGETHVPFNPEVHQAMTMLESADHEPNHVMMVMQKGYTLNGRLLRPAMVAVSKAKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RING1_GOSHI
Sequence: MSSDGNVTGGGGANTVGVTNKPFFCYQCNRTVNVTISPPSSDPTCPICNEGFLEEYDNPNPNQGSGFLNPNPNSIPFHDLFLTLSDPFASLLPLLFPSSSSTTTSSSASIDPNNPSLSGPTRSGRGDPFAFDPFTFIQNHLNDLRSSGAQIEFVIQNNPSDQGFRLPANIGDYFIGPGLEQLIQQLAENDPNRYGTPPASKSAIEALPLVNITKSNLNSEFNQCAVCMDDFEEGTEAKQMPCKHLYHKDCLLPWLELHNSCPVCRHELPTDDPDYERRVRGAQGTSGGNDGDNSGQRSDGDNRTVERSFRISLPWPFQARGPGPAPGDNAETRQEDLD
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Promotes polyubiquitination of target proteins.
What are the official names of this protein?
E3 ubiquitin-protein ligase RING1, RING finger protein 1, RING-type E3 ubiquitin transferase RING1.
Protein: NUSAP_DANRE
Sequence: MDLDSLKYAELQRLAKEVGLKANMKAERLLKALKEHFSQQQLSENGNDAAASDAHDSVPPVDAHAATYVTERRGKGRTAKRKLSEPTPIISPTEEKTPQDEGRRGSKRRKVSSAKDTQTPVPAEAFAKENTMEKESGDLNPDSESGPTETGVKGRRTVGKIPRHKGLMKRKPAMRPTTPNFKKLHEAHFKKMESIDSYVQRKNKQMEVLRNSVKELKTLSEKTLKKPEAKAQTKVPSSRASLFSPAVQKTAVPERRRLTQQPVSKSALKDTATFRPTVLTTNKINVRFSQATQDNEYKRSLVKTPARMSPHMPLTSTPGRKSDVRSKAELNRSASTITKTPGATPFVFNGNNSISTTPGTTKKNTFDLKASLSRPLTYKPHKGKLKPFGDAQENTALNKSQTVPSHQKNYKQHQVQTREERRVKHTEDRKQKKEKMLGARRGLVMA
What is the function of this protein?
Microtubule-associated protein with the capacity to bundle and stabilize microtubules.  May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity).
What are the official names of this protein?
Nucleolar and spindle-associated protein 1, NuSAP.
What is the protein family that this protein belongs to?
Belongs to the NUSAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Associates with mitotic spindle microtubules, particularly in the vicinity of chromosomes.
Protein: CH25H_MOUSE
Sequence: MGCYNGSELQDLGCSSQLLLQPLWDTIRTREAFTRSPIFPVTFSIITYVGFCLPFVVLDVLYPWVPILRRYKIHPDFSPSVKQLLPCLGLTLYQHLVFVFPVTLLHWVRSPALLPQEAPELVQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSFWELLSLTFFDVLNVAVLRCHPLTIFTFHVINIWLSVEDHSGYDFPWSTHRLVPFGWYGGVAHHDMHHSQFNCNFAPYFTHWDKMLGTLRSAPLPESLCACGERCVNSRERCAVHLIQKKKQT
What is the function of this protein?
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097, PubMed:29033131).  Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953).  May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097).  In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (PubMed:9852097).  Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131).  Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity).
What are the official names of this protein?
Cholesterol 25-hydroxylase, Cholesterol 25-monooxygenase, m25OH.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CMT1_MAIZE
Sequence: MAPSSPSPAAPTRVSGRKRAAKAEEIHQNKEEEEEVAAASSAKRSRKAASSGKKPKSPPKQAKPGRKKKGDAEMKEPVEDDVCAEEPDEEELAMGEEEAEEQAMQEEVVAVAAGSPGKKRVGRRNAAAAAGDHEPEFIGSPVAADEARSNWPKRYGRSTAAKKPDEEEELKARCHYRSAKVDNVVYCLGDDVYVKAGENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHKHDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYDMSYSVAYSTFANISSENGQSGSDTASGISSDDVDLETSSSMPTRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAVDFNSFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVQDVDSNLASSEDQADEDSPLDKDEFVVEKLVGICYGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGHKRKILPLPGDVDVICGGPPCQGISGFNRYRNRDEPLKDEKNKQMVTFMDIVAYLKPKYVLMENVVDILKFADGYLGKYALSCLVAMKYQARLGMMVAGCYGLPQFRMRVFLWGALSSMVLPKYPLPTYDVVVRGGAPNAFSQCMVAYDETQKPSLKKALLLGDAISDLPKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKDMLDWSFGEGAGPDEGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIERVKLSSGKPLVPDYAMSFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVIIHPTQARVLTIRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARALGYCLGQAYLGESEGSDPLYQLPPSFTSVGGRTAGQARASPVGTPAGEVVEQ
What is the function of this protein?
Involved in the CpXpG methylation and in gene silencing.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 1, Chromomethylase 1, DNA cytosine methyltransferase MET2a, Zea methyltransferase2, Zmet2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARSL_MACFA
Sequence: MLHLHHSWLCFRSWLAGMLSVLLGLVPSASSNISTSRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCAHWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWTPVIWSALWAVLLLTGSYFVGALIVHAGCLLMRNHTITEQPMRFQKTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGQILDTLDMEGLTNSTLIYFTSDHGGSLENQLGRTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGQVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCEGFLHAARWHQRDRTTWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVLHHDPPLLFDLSRDPSETHVLTPASEPVFYQVMERVQRAVREHQRTLSPVPLQLDRLGNIWRPWLQPSCGPFPLCWCLREDGPQ
What is the function of this protein?
Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate (By similarity).  May be essential for the correct composition of cartilage and bone matrix during development (By similarity).  Has no activity toward steroid sulfates (By similarity).
What are the official names of this protein?
Arylsulfatase L, Arylsulfatase E, ASE.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack.
Protein: PDXB_VESOH
Sequence: MKLVIDDACYAHKEIFSHFGNISTIAGRDINSTSVKNADILIVRSRTKVNHVLLDGSQVKFVGSTVTGLDHIDQDYLKSKGIKFFSAQGCNSMAVAEFVISAIVNLADELDFDYQKKTLGIIGIGNVGARLAKKAKLMGIKTLLNDPPRQMYENLPNFVDLKTTLSADIVTFHTPLTVNGKYPSYQLLNENNFHYILDKTILFNVARGGIIKETIWQEYKTLANIIDCWEDEPNINLKLQNTAYLATPHIAGHSIDAKFIGSFMVYEALCDFLGKKQDSNIKNLINLDKLSINKDTLKNTLNKIYDFRQDAKAIQDINNFEDYRRNYPVRYEWHHFKSKTTLPIA
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_ALBFT
Sequence: MDVVIMAAGKGTRMKSKLPKVLHLLAGRALLQHVVDTAAQLSARQVVVITGHGAMEVEAAVSGNTGASAGFDINFVRQEPQLGTGHAVQQAVPLLRDDGMVVVLSGDVPLIQAATLRHLIAAAGTDKLALLTIDFADPTGYGRIVRRGDVVQAIVEQKDATPVQREITEVYSGIMALPARQLKAWLARLDKQNAQGEYYLTDIVKFAVADGVPVVAHKIADATQVAGVNSPVQLAALERAFQSKVALQLMEQGVRLADPARLDVRGQLHCAQDVSIDVNCVFEGVVTLGEGVKIGANCVIRNATIAAGAVIHPFTHIEGGQPGSKDAVEVGAGALIGPFARLRPGAKLGQAVHIGNFVEVKNSTLARGAKANHLAYLGDATVGERVNYGAGSITANYDGAFKHRTVLEADVHIGSNCVLIAPLTIGAGGTVGGGSTVTKDTPPGALTVARAKQVSIANWKRPSK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAL1_BACLI
Sequence: MPEAPELDIFQKEVQEMKADQKSLEQRVSTLERTSDRHDQQIISINEKLNKIEENTTWIKRSITGAIITAVSTGIIGGAIAVFYNLLQK
What are the official names of this protein?
Uncharacterized 10.1 kDa protein in ORF3 5'region.
What is the protein family that this protein belongs to?
To B.licheniformis xpaF1 and to B.subtilis XhlA.
Protein: LAGR1_CAEEL
Sequence: MLGPEYNITHPSIYRTSTANPIVLAGLVFESIPHWFRRYARLRPDYSFPSSMISDFKKVSLSNSELYTVLILASIFTFLRYYLQIRLESWTQQHNIYPRFAHKVPESFWKLTYYGTVWIFAFYFHMCVDSHDIFNDPLSMWIEWESGGRPKMHWQVQVIYAVQSAFYIHSIYATLFMDLWRKDSWLMFVHHFIALGLLFLSYVDNFTLPGALVLFLHDNSDATLEITKLSFYLKKRTNRQYYKYYFLMGNAAFILFAIIWVIFRLYWYTCKLLYATIYGAVYLGPQDAPFFPLLGAMLLIIFAMNVYWFNFIARMIWRVALTGEDPEDNREWDTTAVSGLNQQKLDELATEKCHLKPKNV
What is the function of this protein?
Catalyzes the acylation of sphingosine to form ceramides.
What are the official names of this protein?
Probable ceramide synthase lagr-1.
What is the protein family that this protein belongs to?
Belongs to the sphingosine N-acyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS10_BRAHO
Sequence: MKEQKIRVKLKAFDIELIDQSAQSIVASVKKTGARVSGPIPLPTSIRKVTVIRSPHVNIKSREQFEMRIYKRLIDIFDVTPQTTESLKKLALPAGVDVQLK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: YMB8_YEAST
Sequence: MVSKDQTSFNKRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYRKPFFITYTNTAAFIFYLFPTAKAVVVNYKDTGRANVHRELIMEEEGTGSDSNRSVDMTSPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLAFTSVASQTILSTTSSFFTLFIGAICHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIADVSGDDNDAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLIVLDFFGWEPFSLPKDPKVVVIIFVNCLITFVSDFCWAKAMLLTSPLTVTVGLSITIPLAMFGDVIFKHKTMSALYLFGATLILGSFFIINKSSEEEHFENSITASNYESVEVPAANN
What are the official names of this protein?
Uncharacterized vacuolar membrane protein YML018C.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: FGD2_RHOJR
Sequence: MTQQLKLGYKASAEQFGPRELVELAVLAEKHGMDSATVSDHFQPWRHNGGHAPFSLSWMTAVGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIMLGAGTGEALNEIATGYTGQWPEFRERYARLRESVQLMRDLWTGERTDFKGEYYSTTGASIYDVPECGIPVYIAAGGPVVARYAGRAGDGFICTSGKGMELYTDKLMPAVSEGATKAERDVTSIDKMIEIKISYDTDPEAALENTRFWAPLSLTQEQKHSIEDPIEMEAAADALPIEQVAKRWIVSSDPDDAVAQVKQYIDAGLNHLVFHAPGHDQKRFLELFDRDLAPRLRALG
What is the function of this protein?
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase 2, FGD 2, G6PD 2.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: SYY_DECAR
Sequence: MYQSPLIQDLHDRGLIAQITDAAALDKLLTEESVTLYCGFDPTADSLHLGHLVPVLILKRFQEAGHKPIALVGGATGMIGDPSFKATERKLNTPDVIASWVGKIRGQVEPFLKFDGANAAIMANNYDWFGGMNCLEFMRDIGKHFSVNAMIKKESVQQRLTREDQGISYTEFSYSLLQGYDFAELNKRYGCVLQIGGSDQWGNIVAGTDLTRRLHQKHVFGLTLPLITKADGTKFGKTESGAIWLDPKKTSPYAFYQFWLNTSDADVYKFMNFFTFLPVARIAEIEAADKASGTKPEAQRILAEEATRLVHGEVALMAARRITECLFSGQLADLTENDLEQLAQDGMPGVQLEKSNTGLIDALVASGLAKSKSEARTFIQSGSVAINGNKAEALDHAIGGDELLYGRFTILRRGKKNYGLISWQ
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_BURTA
Sequence: MTAQRRQAPIASRETLQALLSEGAEALGVALSDAQRGALLDYVALLAKWNAVYNLTAIRDPRQMLIQHILDSLSIVPHLGARGAAATALDVGSGGGLPGIVLAIALPGWQVTLNDIVQKKSAFQNQAKAELKLGNLSVVTGRVETLRPGADVQGKFDVIVSRAFADLADFVTLARHLVAPGGSIWAMKGVRPDEEIGRLPDGARVKQMIRLTVPSLDAERHLIEVELDEAI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_BACC0
Sequence: MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERLKEAAIVCTRKYGTGATASRLVVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTVFSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTFSKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: LEXA_BORBR
Sequence: MATKLTERQQEILDLIRQTVARTGFPPTRAEIAQALGFRSPNAAEDHLKALARKGAIELTAGASRGIRLKVPDSATPSAQLTHPLLAQLVLPLVGRVAAGSPILASEHVEREVGVDPGLFAQTPDYLLKVRGMSMRDAGILEGDLLAVKRAAEARNGQIVVARLGDEVTVKRLQRQNGRIELLPENPDFAPIVVANTDEFALEGIAVGLIRTQPLH
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: Y1335_BACC7
Sequence: MLYLHDVWVNWFEGEENGYNVCHFYEWRKDDTIELLDQVPLLKVDSTLYHYIENELLELPQKMLEDVHHKAYIRKNHERLQQEYCFVVTDGKGIIAIDTIGYNVPIRKSRLIPRQEQMVYEMVENVQAEKYEFQVEEMEKEHHILSPSPFIMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWFTEWDPSAYGMVQHMEFEDIWAKLYEEAKTGWSEKHEQLCERLVKGQPFFEKLWEMENEQKVN
What are the official names of this protein?
UPF0736 protein BCAH187_A1335.
What is the protein family that this protein belongs to?
Belongs to the UPF0736 family.
Protein: CF206_BOVIN
Sequence: MPPTQAESVIKNIIREIGQECAAHGEIVPETLVAFMVKAVVLDPSNGFNTDRTLTKSDVQKLVKLCVNRLLDSKNPSLDTIKMQVYFDMNYTSREEFLEEHHQVIESRLSSVSREITDSRACVREELESLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQTELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILQEAIPATTQHVDSQLEVVQEQAYRYTAILEKVAKNPLMSQELQPYMLREALYNVRQCEIFLQVILSDIITCAQEVEMMIKQLEAQLEQLKLTVKSKTAVPTSQVFPIFIALSNLWTSFQDETVLISILSNLTTHLEPFLGAHDLFFPEKVMQVLLDGVTVKTDVCRIKEHIEDKVNVADFKKLEWLFPETTANFDKLLIQYRGFCAYTFATTDGLLLPGNPSIGILKYKDKYYTFNTRDAAYSFAENPENYIDIIREKAKRNAELIQLLELHQQFESLIQYSQMKEVDKRYIKPITKCETGTQTDTHLLPPTIVRSYEWNEWELRRKAIKLANLRRKVTHSVQTDHSHMRRENCSQVYPSKDVGTQSMREGSSRVPRPQIYIAGLRGGQTKTTYGVKVNLTRAVDET
What is the function of this protein?
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity).  Required for the establishment of radial spokes in sperm flagella (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 206.
What is the protein family that this protein belongs to?
Belongs to the CFAP206 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Protein: YORB_BACSU
Sequence: MSEQKLRIGEIRYEVFDDYDPLTEEYLGKNLANAYFIAQIKKENVVQVGNRKINYSSDVKIGFDAFGEETKEKIKEYLLAAYSLIAEGAKDDGLVEYL
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YorB.
Protein: CSF3_BOVIN
Sequence: MKLMVLQLLLWHSALWTVHEATPLGPARSLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQSLQLTSCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLAEP
What is the function of this protein?
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.  This CSF induces granulocytes.
What are the official names of this protein?
Granulocyte colony-stimulating factor, G-CSF.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CCL5_MOUSE
Sequence: MKISAAALTIILTAAALCTPAPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS
What is the function of this protein?
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils.  Causes the release of histamine from basophils and activates eosinophils.  May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5.  May also be an agonist of the G protein-coupled receptor GPR75.  Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases.  By activating GPR75 may also play a role in insulin secretion by islet cells.
What are the official names of this protein?
C-C motif chemokine 5, MuRantes, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.