PharMolix/UniProtQA huggingface dataset:
Protein: TILS_CUTAK
Sequence: MARRELGPAALAVAQAVERMVRGVDRFVVGCSGGPDSLALALASKWASRRCESGVRVVIVDHQLQQGSDEVAERTRDLLVRRGMDACVRRVDVDADDPDGPEAAARTARRAALLDVAGDEPVLLGHTRDDQAEQVLLSLARGSGATSLAGIRPRSGQFWHPLLEVRRAQTVQACREWEVEPWQDPHNGDPRFLRSRVRTELMPVMEEVLGPEVAASLARSATLLAGEDEVVARVARMWADEHGVKANELPGLRGVEVGLARRVVKEWLPQARMVHVDAVLGLLDGPGGAGVDVPGGRVEMRQGTLYLARRL
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y492_ACIC5
Sequence: MNPFKMQQMLSQAKEMQEQMQEKLAATVVEASSGGGAVSVKMNGKKELLKLTIDPAAVLSLSGANPDVEMLEDLITAAINEAGRRAEEILKSSMQGLLGGLNLPPGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein ACP_0492.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DNAK_STRCO
Sequence: MARAVGIDLGTTNSVVSVLEGGEPTVITNAEGARTTPSVVAFAKNGEVLVGEVAKRQAVTNVDRTIRSVKRHMGTDWKVNLDGKDFNPQQISAFVLQKLKRDAESYLGEKVTDAVITVPAYFNDAERQATKEAGEIAGLNVLRIVNEPTAAALAYGLDKDEQVILVFDLGGGTFDVSLLEIGDGVVEVKATNGDNNLGGDDWDQRVVDYLVKQFQSGHGVDLAKDKMALQRLREAAEKAKIELSSSTETTINLPYITASAEGPLHLDEKLTRAQFQQLTSDLLERCKTPFHNVIKDAGIQLSEIDHVVLVGGSTRMPAVAELVKELTGGKDANKGVNPDEVVAIGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGIMTKLIERNTTIPTKRSEIFTTAEDNQPSVQIQVYQGEREIAAYNKKLGMFELTGLPPAPRGVPQIEVAFDIDANGIMHVTAKDLGTGKEQKMTVTGGSSLPKDEVDRMRQEAEKYAEEDHARREAAESRNQGEQLVYQTEKFLKDNEDKVPGEVKTEVESAVAELKEKLKGEDTAEIRTATEKVAAVSQKLGQAMYADAQAAQAAGGEAPGADAGAEGKGADDDVVDAEIVDDERKDGAA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FTSHA_ARATH
Sequence: MIFSKLGSSLARSSRSKGFVYGGGVRSAVFNQGRLRAPQNLEAAVNQVDGGLGFLRRHFASFAARKGLEAGDLSRAFANPRLRRFFSSQTPKKKNYENYYPKDSKKAPKNEQKSESRDGSKKNENENAGDAFSNEYQNMLIPLMAIALILSTFSLGSREQQQISFQEFKNKLLEAGLVDHIDVSNKEVAKVYVRSSPKSQTTEEVVQGPGNGVPAKGRGGQYKYYFNIGSVESFEEKLEEAQEAIGVNSHDFVPVTYVSETIWYQELLRFAPTLLLVATLIFGARRMQGGLGGLGGPGGKAGRGIFNIGKAQITRADKNSKNKIYFKDVAGCEEAKQEIMEFVHFLQNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESAVPFLSISGSDFMEMFVGVGPSRVRNLFQEARQCAPSIIFIDEIDAIGRARGRGGFSGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFQIYLKKIKLDHEPSYYSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFDSAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGRISTGAQNDLEKVTKMTYAQVAVYGFSDKIGLLSFPQREDEFSKPYSNRTGAMIDEEVREWVGKAYKRTVELIEEHKEQVAQIAELLLEKEVLHQDDLTKVLGERPFKSGETTNYDRFKSGFEESEKESQKESVPVKPVEDDGIPPLEPQVVPT
What is the function of this protein?
Probable ATP-dependent zinc metallopeptidase.  Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FTSH 10, mitochondrial, AtFTSH10.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: IHFA_BORPE
Sequence: MGTTMLAEPRTLTKAELAELLFERVGLNKREAKDIVDTFFEEIRDALARGDSVKLSGFGNFQVRDKPPRPGRNPKTGETIPIAARRVVTFHASQKLKSVVEQPNSPPDPASAE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL30_SULIM
Sequence: MVELLGIIRIRGWAKAPWYINETLEMLRLRYNFNTMMYPKTSQILGMLNKVSPYVTWGEIDPDTLKLLIIKRLETAKGDKVSDSYVKEVLKIENIDTMVKQLYEGKIYLHKLDQYFKLPIRLHPPKGGFKGSVKRPYKNKGEFGYRGDKINELMRRMM
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: UPPP_OCEIH
Sequence: MNVFENFWTIVHYFVLGLVQGITEPIPISSSGHIIIFRELFGIEARGLSFEIFVNLASLLAVLIIYRKDIVRLAVNSWNFIFKQEKESKSDFMFVVYLVLATIPVGIVGVLFGDEIGAFIGEDGTTVVGITLLITAAAIWMIRNLRGRKIEGDLSTKDAVIVGLAQAVAVTPGISRSGATLVASMLMGMKQDTALRFSFLLYIPVSLGSSILEIPNIVRDPNVQELWIPYLVAFITAFIASYFALKWFMNIMRHGNLKYFAYYCVIVGVLVLIFL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUG96_SCHPO
Sequence: MVIFSSYFSKQMNRFSTPFVFFFKKLNNTLKKSLQFIMRFHSYHPMFICLLRDSSRNENRKKKVSIGLRTIMRAFSFLMQVATCLIRYSLILTCLVAILLSVLWRIQFAALRMHDLIEEELKMFVLQHNCTLADLWSGKCPSSEDE
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 96 protein.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein.
Protein: NFU1_MOUSE
Sequence: MAAAERAWGAAVGVVRLCRRFCHVATPHTFKKQPLHQYVRRPLFPLRAPLCNTVRFMFIQTQDTPNPNSLKFIPGKPVLETRTMDFPTPAAAFRSPLARQLFRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPPPPGEAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQVMDDDESDEKEANSS
What is the function of this protein?
Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.
What are the official names of this protein?
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial, HIRA-interacting protein 5, mHIRIP5.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol.
Protein: BAMD_NEIGO
Sequence: MKKILLTVSLGLALSACATQGTADKDAQITQDWSVEKLYAEAQDELNSSNYTRAVKLYEILESRFPTSRHARQSQLDTAYAYYKDDEKDKALAAIERFRRLHPQHPNMDYALYLRGLVLFNEDQSFLNKLASQDWSDRDPKANREAYQAFAELVQRFPNSKYAADATARMVKLVDALGGNEMSVARYYMKRGAYIAAANRAKKIIGSYQNTRYVEESLAILELAYKKLDKPQLAADTRRVLETNFPKSPFLTHAWQPDDMPWWRYWH
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity).  Required for efficient transformation of Neisseria gonorrhoeae by species-related DNA.
What are the official names of this protein?
Outer membrane protein assembly factor BamD, Competence lipoprotein ComL.
What is the protein family that this protein belongs to?
Belongs to the BamD family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TSAD_BRUC2
Sequence: MRVLGIETSCDETAAAIVQRDDMGEGRILSNVVLSQIAEHEPYGGVVPEIAARAHVEALDRLVDRALNDAGLKLYEVDAVAATAGPGLIGGLIVGLMTAKALAMAAQKPFYAVNHLEGHALTARLTDGLPFPYLLLLVSGGHTQMVLVRGIGDYERLGTTIDDALGEAFDKTAKLLGLPYPGGPAVERMALQGDQKRFALPRPLKGEARLDFSFSGLKTAVRQTATELVPLTDQDVTDICASFQAAVADTLSDRVGRSLERFKTEFPDCATPSLVVAGGVAANKTLRAALENLCTRHGFAFIAPPLNLCTDNAAMIAWAGAERAATQAPDSLDIAPRSRWPLDEKSAPVFGTGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_AKKM8
Sequence: MPPSPPRPPKFPGSGRPESPNWGVWVMVLLIVGVLAFGFFTPESFGLGPRKENLESFEAQYKAGRVVLNDPKAPVEVVLSENGSEGVIHALVYRKEIQPKVEMTPFALTYSMSLPDRDKPLLNELSGYRVVESPYRTEEGKNVSLIPEGAQKLSVPEFNRLALEGRIAGGKDGIILAEDGNQNVLVGQIVTRIWPAATGDASVDKQRFERVEVPFTLEFQGDRVKQLLGPDTKFKRESGSWGGILLNLLPIVLILVILFFMFRAQSGGARGAMSFGKSRARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRDLGATIPRGVLMVGAPGTGKTLLARAIAGESNASFYSISGSDFVEMFVGVGASRVRDMFEQAKRTAPSLIFIDEIDAVGRQRGYGMGGGNDEREQTLNALLVEMDGFENNSNVIVIAATNRADILDPALLRPGRFDRQVVVNLPDVRGREQILQVHARKVKMAPGVSFERIARGTSGFSGAQLANLVNEAALLAARKGLKEITEAELEEARDKVSWGRERRSLAINERGRRITAVHEAGHAICLLKTPHSEPLHRVTIVPRGGALGMTMWLPSDDKMHQLRSEMLDQLVVAMGGRCAEQIVFGDVTSGATGDIKSATNLARRMVCEFGMSEKLGLIEYGEHQGEVYIARDLGTRSRNYSESTAELIDSEVRFLVDSAYERAMAILTENRDKLDILTEALMEFETLEGSQVMDILEYGEMKNPPARVTPPPMPSEVEEQPGKDDSGHNEKKEAEETRADGAEERKMEEELEQAERAPFSYNPVDEFGKDGGEKK
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: ERA_RICPR
Sequence: MTNQIQKTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIVTLKDTQIILYDTPGIFEPKGMLEKAMVRCAWSSVYSADLVLSIIDSLKPLDNIAHNILNQFCLLNIVPIFLLNKIDIESKYLNDIKAFLKITHPKSLLFPISALLGKNVDVLLEYIKSKAKVSPWLYADDDITNLPMRFIAAEITREQLFLNLQQELPYKLTVQTEKFEELKDKSIKINQVIVISRENYKAIILGKNGAKIKDIGVKSRVQLEQFFCVPVHLFLFVKVHAFWENNQEFYQYMKI
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: PAP1_ASFK5
Sequence: MSSLPKTDFNVPKYQLIAQKREANAAEIEAALEVVREFIIKKKLILYGGIAIDYALHLKGSSIYPEGERPDFDMFSPNHVEDAYELADLLYEKGFKQVGTVRAIHVQTMRVRTDFVWVADLSYMPSNIFDTIPTLTYKNLKIIHPDYQRAGLHLAFCFPFDNPPREDVFSRFKKDLQRYNLIEKYYPIPVVPVKSTYENKTFSIPFKRVAIHGFAAYALLYQTLNELRMTCKVPEWKTEFPQPSYSYHKNDKNITLTVDMPKAYPSLVLATYNPEEIIKEMGLHLTEICEPYMDYSPPIFKTKDIHFFSTMFKELAISMIQDNIIVVSPQYLLLYFLYGAFATPADKALFLFYYNATLWILEKADSLLNIIQKQTSPEEFMKFANTSPFVLTTRVLRCSQDRCTFSPAYRISLANDVQQSQLPLPKTHFLSNFLPDISTLPYNYYPGKGKDRPTNFSYEKNLLFNIGGKCTQLAM
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.
What are the official names of this protein?
Putative poly(A) polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae poly(A) polymerase catalytic subunit family. Highly divergent.
What are the subcellular locations of this protein?
Virion.
Protein: CMOB_ECO55
Sequence: MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSTGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIVDVCVTTTEEQRRTEWMVTESLSDFLDPHDPSKTVEGYPAPKRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: RU1C_DANRE
Sequence: MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFPGAPPPGGSLLPHPSIGGPPRPGMLPAPPMGGPPMMPMMGPPPHAMMPGGPGPGMRPPMGGPMQMMPGPHMMRPPARPMMPAVRPGMVRPDR
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUTI_XANC8
Sequence: MHCDVLWHNARLMTLDAGDGGLGSVDDGVVACQDGTIVYAGPAADAPPLQASHVHDCQRRWISPGLIDCHTHLVYAGNRANEFEQRLRGASYAQIAAAGGGIVATVRATRAADDAALLAASLPRLDALLAEGVTTLEIKSGYGLTLEDEIKQLRVARQLATLRQVEVVPTFLGAHAVPPGAQGQTYIDAVCQEMIPAVAAQGLAEAVDVFCEHLAFSPAQAEQVFVAARAHGLQIKIHAEQLSNQHGAALAARYGALSADHIEYLDQAGIDAMANAGTVAVLLPGAFYFTRDTQLPPIPALRAAGVPLALATDCNPGTSPLTSPLLAMNMAATLFRMTVDGCITGFTREAARALGRGNRLGRLRAGMQCDLAIWDIDAPADLVYRMGFNPLHTRVWRGHPC
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_STRZP
Sequence: MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAVLAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLRAERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL15_MYCTA
Sequence: MTLKLHDLRPARGSKIARTRVGRGDGSKGKTAGRGTKGTRARKQVPVTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGAVRKNALVKVLGDGKLTAKVDVSAHKFSGSARAKITAAGGSATEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MAZF2_MYCTU
Sequence: MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Upon expression in E. coli partially inhibits cell growth after one cell generation (PubMed:16611633).  Its cognate antitoxin is MazE2.  Probably an endoribonuclease (By similarity).
What are the official names of this protein?
Probable endoribonuclease MazF2, Probable toxin MazF-mt4.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: YHIT_BUCAP
Sequence: MNNKDLIFQKIIKRETSTHIIYQDKIVTAFEDIAPKAPIHIIVIPNIFIKTLNDINQKNKNIFAHMLYIAVKIAKNKKISEDGYKIVMNCNKNGGQEINYLHMHLLGGEKLKALY
What are the official names of this protein?
Uncharacterized HIT-like protein BUsg_345.
Protein: TAT_HV1YF
Sequence: MEPVDPRLEPWNHPGSQPKTACNNCYCKRCCYHCLYCFTKKGLGISYGRKKRSQRRRTPQSSKSHQDLIPEQPLSQQQGDQTGQKKQKEALESKTEADPCD
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: GLGA_HAEI8
Sequence: MKILHVCSELYPLLKTGGLADVLGALPQAQNQIGLDARVLLPAYPAIIAGIQNTQVVAEFDNFAGHVVLRYGEYNGVGIYLIDAPHLYGREGNPYHDAYYNDYGDNYKRFALLGWVGAELATGLDSWWRAEVVHAHDWHAGLCAAYLFNKGRPAKSVFTIHNLAYQGQFSYHHLYEIGLPTGMFHVEGLELFGQISYLKSGLFYSDASTAVSPTYAEEITTPEFAYGLQGLLSGLKAQGRLVGILNGVDENIWHPNVDQYIPHHYKLKYMAGKKKNKAELQAYFNLPQDESALAFVMVTRLTEQKGVDLLIESADEIVKQGGQLMILGSGAPHFEQGIRELAERYPQNIAVKIGYDEALSHLMVAGGDVILVPSRFEPCGLTQLYGLQYGTLPLVRKTGGLADTVVDSTSESIKARTATGFVFESATPEALRHCLQRAFALWQKPRAWAMVRTDAMEQDFSWRKAAEQYRTLYERL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RIMM_SULDN
Sequence: MSKQSNKLLHIATIGKSVGLGGDMKLHIKSDFPEQFKKGVSFFINENETLTLSDINHERALIKFVGYNSPEDAKKLTNKNLYTTIERTRKECRLEKDEYFWFDIEGCSVVEDGKVLGIVDELDRMGITNYLCVITDETLVKSGFAKSFLIPFREPFTINTDIKEKIITVIGAMDILEAS
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANT_ESCF3
Sequence: MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSVGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPLWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSTGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTELAYNPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALGSLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_CHLAA
Sequence: MANVLVAMSGGVDSSLAAALLLEAGHQVTGVTMHLWDDDEQGLRESLCCAAEAAASARRVCALLGIPFYVFNYQREFRRHVIDYFIRAYTHGLTPNPCVECNRMIKFRALLDRARTLGFDAVATGHYARIIQGEDGRYQLWRAVDLEKDQSYMLHMLGQAELSRLIFPIGAYTKREVREMAAARGLPSADREESQDICFVPDGDYRNLLRIESPESLVPGPIVDLEGREIGRHRGLPLYTVGQRRGLGLGGGEPRYVVAIDPARNALIVGPAAALNRARFTVIDACWVDDAPPAESFTCLVQVRAHAEPLPARVSQQPDGRWLVELERPQRAVSPGQAAVFYRGQQVLGGGWIARPEVA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_PSEPG
Sequence: MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDQASEGAISAVLKRGDLAGKPGQTLLLQNLAGLKAERVLLVGSGKEEALGDRAWRKLVASVAGVLKGLNGADAVLALDDIAVSNRDAHYGKYRLLAETLLDGEYVFDRFKSQKAEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKDLGKAHKGLKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPINLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTSGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWVSGGKDKGATGRPVPLLTQYLLDRAGA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHD_MYCMM
Sequence: MTAVQWRSHLTDDQQRQVRDLVTAATQVDGVAPVGEQVLRELAQQRTEHLLVEDQSPGKSAIGYLNLSPAHGADAAMAELVVHPQARRRGIATAMVRAALAKTGGRNQFWAHGTLAPAQATASALGLTPVRELVQMRRSLRQLPEPVIPNGLQIRTYAGTEDDAELLRVNNAAFAYHPEQGGWTEADLAERRGEPWFDPAGLFLALEGSEGAEDSPRGQPRLLGFHWTKIHLDDPGLGEVYVLGVDPAAQGRGLGRTLTMIGLRSLAQRLGDRDLGRESTVMLYVESDNIAAVRTYQGLGFSTHSVDTAYALAAPDAALA
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.