PharMolix/UniProtQA huggingface dataset:
Protein: VITF3_VAR67
Sequence: MDNLFTFLHEIEDRYTRTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHPAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFEREKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVNIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCIHMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLTATALDEKLFLIKKMAKHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCINYVTKSENMIEMMKERSTILNSIDIETESVDRLKDLLLK
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
What are the official names of this protein?
Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG150 family.
Protein: SYA_STRA3
Sequence: MKELSSAQIRQMWLDFWKSKGHSVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPEWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPDNIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYDPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVPTVGQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALSDSLRDLQKENVELKEKAAAAAAGDVFKDIQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKGLAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAENL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_LEVBA
Sequence: MVDVNKFESMQIGLASPDKIRSWSYGEVKKPETINYRTLKPEKDGLFDERIFGPTKDWECACGKYKRIRYKGVVCDRCGVEVTRSKVRRERMGHIELAAPVTHIWYFKGIPSRMGLVLDMSPRALEEIIYFASYVVLDPGNTPLEKKQLLSERDYRDKLLEYGSDAFKAEMGAEAIKKLLMSVDLDKEVTELKEELKEATGQKRTRAVRRLDILEAFVMSGNRPEWMVMDAIPVIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNSRLKRLLDLNAPGIIVQNEKRMLQEAVDALIDNGRRGRPVAGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVGPSLKFNQMGLPVPMALELFRPFIMKELVARGLASNIKNAKRQIDREDDDVFNVLEDVIKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLACEAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAHHILAPASGKPVVAPSQDMVIGNYYLTMEEANREGEGMIFTDLDEATLAYRNGIVHWHTRVGVQVTSMPDKPFTDEQRSKIMVTTVGKLIFNNILPKSFPYLNEPTSTNLNGYVPDKYFLEPGEDIHDYLQNAEIIPPFKKGFLSDIIAAVYQQYKVTATSELLDRIKDLGYNESTKSGLTVGMVDVTDLKEKPEIIAAAHKQVSTVTKQFRRGLITDHERYERVIGIWNDAKDEIQNALIHSFDQQNPIFMMSDSGARGNISNFTQLAGMRGLMAAPSGDIMELPITSNFREGLTVMEMFISTHGARKGMTDTALKTANSGYLTRRLVDVAQDVIIREKDCGTDRGLKIRAITDGNEMIEPLYDRILGRYTQKTVYDPQTGDVIVPKNQMIVEDTAQQIVDAGVEEVTIRSAFTCNTEHGVCEHCYGRNMATGDEVEVGEAVGTVAAQSIGEPGTQLTMRNFHTGGVAGNEDITQGLPRVQELFESRNPKGKAEITEVTGTVESIEENPAERTKEITIKGEADTRSYTLPITARMRVSEGDFIHRGGALNYGSVDPKELLRVRDVLSTETYILGEVQRVYRMQGVAISDKHVEIMVRQMLRKVRIMDPGDTDVLPGTLMDIQDFRRANYQTLIDGGIAATARPVILGITKAALETNSFLSAASFQETTRVLTDAAIRGKNDPLVGLKENVIIGKIIPAGTGMPDYRQIKPKEVGGTSTEGVYSISDLEKQMQEDSQA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: SYH_TREPA
Sequence: MRVGSAVSPKVLKGFRDLLPDEEIERALLVEKLTVALRQMGFVPIDTPALEYTEVLLRKSEGDTEKQMFRFVDKGGRDVALRFDLTVPLARFVATHYARLYFPFKRYHFAKVWRGEKPQMGRYREFTQCDFDIVGSDSVCADFEILKSIRHMLYMAGAEHIRIHVAHRGLFDRFLRALSLSDQAEHILRIIDKRAKMAPHVLTAQLESLCDPVRVQKIMTYVSAGEVDGVAPSFEHTLSAIETLTGGVSEESTRLRKIYELLCAVNIQSSYVFDPSITRGFDYYTGMVCETFLTQLPHIGSVCSGGRYDHLTALYMKDAVSGVGASIGLDRLYAAFQQLGMSREHVCFVQALIFCQDSALMDVYQKLCSYFAVQVATEVFPDPRKLSQQYAFAEKKGIRWGIFVEQRNAVVEDCLLVLRDLSTRKDTRLPAHEVRRRMAAEG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF7_PONAB
Sequence: MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.  TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2.  Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 7.
What is the protein family that this protein belongs to?
Belongs to the TAF7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CFT1_NEUCR
Sequence: MQCYTELTPPTAVTHSVTLQLVPGQGTNLAVAKASLLQIFKTKVVSAEIDTYATLNGTNTSSKAAAAGRYDSRLVNDDDGFEASFLGGDNIAARADRANSAKLVLVAEVTLPGTMTGLARIKKPSGSSSGGADCLLLSFRDARLSLVEWNVERNTLETVSIHYYEKEELVGSPWVAPLHQYPTLLVADPASRCAALKFSERNLAILPFKQPDEDMDMDNWDEELDGPRPKKDLSGAVANGASTIEDTPYSPSFVLRLSKLEASLLHPVHLAFLHEYRDPTIGVLSSTKTASNSLGHKDHFTYMVFTLDLQQRASTTILAVNGLPQDLFRVVALPAPVGGALLVGANELIHIDQSGKSNGIAVNPLTKQTTSFSLVDQADLDLRLEGCAIDVLAAELGEFLLILNDGRLGLITFRIDGRTVSGLSIKMIAPEAGGSVIQSRVTSLSRMGRSTMFVGSEEGDSVLLGWTRRQGQTQKRKSRLQDADLDLDLDDEDLEDDDDDDLYGEESASPEQAMSAAKAIKSGDLNFRIHDRLLSIAPIQKMTYGQPVTLPDSEEERNSEGVRSDLQLVCAVGRGKASALAIMNLAIQPKIIGRFEFPEARGFWTVCAKKPIPKTLVGDKGPMNNDYDTSGQYHKFMIVAKVDLDGYETSDVYALTAAGFESLTGTEFEPAAGFTVEAGTMGKDSRILQVLKSEVRCYDGDLGLSQIVPMLDEETGAEPRVRTASIADPFLLLIRDDFSVFIAEMSPKLLELEEVEKEDQILTSTKWLAGCLYTDTSGVFADETVGKGTKDNILMFLLSTSGVLYIYRLPDLTKPVYVAEGLSYIPPGLSADYAARKGTAKESVAEILVADLGDTTHKSPYLILRHANDDLTLYQPYRLKATAGQPFSKSLFFQKVPNSTFAKAPEEKPADDDEPHNAQRFLPMRRCSNISGYSTVFLPGSSPSFILKTAKSSPRVLSLQGSGVQAMSSFHTEGCEHGFIYADTNGIARVTQIPTDSSYAELGLSVKKIPIGVDTQSVAYHPPTQAYVVGCNDVEPFELPKDDDYHKEWARENITFKPMVDRGVLKLLSGITWTVIDTVEMEPCETVLCVETLNLEVSESTNERKQLIAVGTALIKGEDLPTRGRVYVFDIADVIPEPGKPETSKKLKLVAKEDIPRGAVTALSEVGTQGLMLVAQGQKCMVRGLKEDGTLLPVAFMDMNCYVTSVKELPGTGLCLMADAFKGVWFTGYTEEPYKMMLFGKSSTRMEVLNADFLPDGKELYIVASDADGHIHILQFDPEHPKSLQGHLLLHRTTFNTGAHHPTSSLLLPAVYPNPSSLSSNSEENSPHILLLASPTGVLATLRPLQENAYRRLSSLAVQLTNGLPHPAGLNPKGYRLPSPSASASMQLPGVDAGIGRNIVDGKILERFLELGTGKRQEMAGRAGYVVGTGAHGVNPAGSGKMMGGGGGLSLGGLRLNGLHGQEGGMEWEEVRGELGVVLGWSGLGYF
What is the function of this protein?
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and hrp1/CFIB.  Involved in poly(A) site recognition.  May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
What are the official names of this protein?
Protein cft1, Cleavage factor two protein 1, Polyadenylation factor 3.
What is the protein family that this protein belongs to?
Belongs to the CFT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLSB_ECOLI
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DEF72_ARATH
Sequence: MKLSILVKAMKRNNGFRYDYCIAECSEHFLDDVCKPVCIDKGYSDGGCIGLAPNFKCCCKK
What are the official names of this protein?
Putative defensin-like protein 72.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
Protein: EGCR1_CRYNH
Sequence: MSGIQFDVSRLCAATISIQGRHFVDSHGRVLHLRGANVSAASKVPATPAPKIHDHAQASYVGRPFRLEEADEHWARLKSWGLTFVRITVTWEALEHKERGVYDEDYLAYLRALLQSMEPYGLVAYIALHQDVWSRYCGGSGAPGWTLEAAGFDLSNEGENLSLSGAAFLDGIKSGRLAGERGLWPTGYQKLAAATMNTLFWGGETFAPLLKVPGQIDGKWVSRNIQVYLQEAFLAATAKLVKAVGDLETVMGFELMNEPHPGFIGIQSIHEWDYTTDLHLGQFPSPLQSFSMGAGHPTPNVPVYTRSFPFPTRVTSHVTANPEGACAWASKECPWEKHGVWRWSEAKQEAAALQQDYFVKNRDGGKVDFYEDFYFPFVRKWEQVIGENISSTKGLKARMVEAIPNELCPEWKEESRPKNMVYAPHWYDLNTLFKKKFGFMSVNVQGLARGMFILRALYFGTAAAKANYALQIKTIVLAARLKLGPVPVIFGECGVPMDINNEEAFRTGDWKWQERSMDALISAMEGALMGFNLWTYNPANRDDIGDDWNAENFSWYSESNRTKLLKNAEKSSDGLDVGARLLNVIVRPYPIATAGNPTSLAYDANACAFTYRFRSPLRVSAAAPTPEEYTEIFLPRRVFRKESTEWTVTAGGKVHVDWERERVFVWFEDSSLTAASIKDDTRPRRIDIWVIGRKVEENWSIAQILVAVVILLLGVLVAYYAQLYEWEKDKMIFQHLREANGM
What is the function of this protein?
Specifically hydrolyzes the glucosidic linkage in glucosylceramide (PubMed:22072709).  May prevent accumulation of aberrent glucosylceramide containing immature ceramide (PubMed:22072709).
What are the official names of this protein?
Glucosylceramidase, Endoglycoceramidase-related protein 1, EGCrP1, Glucocerebrosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: GATA_THEYD
Sequence: MELNKLKLTELVPLISKGEVRPHEIIIDVFKRVQEVEGKVKAYITLTVEKAYDMAREAENAIFSGKKSLLTGIPIAVKDNICTKGILTTCASKILYNFYPPYESTVTSKLLNNKYILIGKTNMDEFAMGSSTENSGFHVTKNPWDLERVPGGSSGGSAAAVAADECIAALGSDTGGSIRQPASFCGVVGLKPTYGRVSRFGLVAFASSLDQIGPITKCVADAALLMNVISGHDPMDSTSAPIESSDFTEYLGKEVKGIKIGIPKEYFIEGMDKEVEERIKDAIKELESLGCIPVEISLPHTEYAVATYYIIATSEASSNLARYDGVKYGLRVQGKDLLEMYMKTRSRGFGTEVKRRIMLGTYSLSAGYYEAYYKKAQQVRTLIKNDFEKAFEKVDFIVTPTAPSPAFKIGEKIDDPLQMYLSDIFTISVNLAGVPAISLPCGFSEKGLPVGLQIIGKPFDEAGILQLAYAYEQSTPWHKMKPLL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: MRAY_SULDN
Sequence: MLYWLSEILHINILGYITIRAGIAFFLALFFTLFLMPRFIRWAQSTSSHQPINEWAPQRHQGKAKTPTMGGIVFIFATILASLISIKFSNLYAVGAVLTLIFFSIIGFKDDIAKIKKNENLAGLKAKTKLILQTTFALIISIFLYTLSDFNTSLYVPFLKNPLFDMGIFAIFFWVIVIIATSNAVNLTDGLDGLATVPSITALASFSIIIYITGNVTMSSYLLMPNINIGEVAIVSSALIGALSGFLWYNCHPAEVFMGDSGSLTIGAFLGYLAIISKSEILLLLIGSIFVIETLSVILQVGSYKLRKKRVFLMAPIHHHFEMKNWAENKIIVRFWIIATLSNVIALITLKIR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GALM_MOUSE
Sequence: MVSVTRTVFGELPSGGGTVEKFQLRSDQLSVDIISWGCTITALQVKDRQGKASDVVLGFAELEGYLQKQPYFGAVVGRVANRIAKGRFTIGGKEYHLPVNREPNSLHGGFTGFDKVLWTPQVLTNGVQFFRVSPDGEEGYPGELKVWVTYTLDGGELVINYRAQASQTTPVNLTNHSYFNLAGQGSPNIYDHEVTIAADAYLPVDETLIPTGVIAPVEGTAFDLRKPVELGTHLQDYHIHGFDHNFCLKESKEKKFCARVRHAASGRILEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGLCLETQNWPDSVNQPQFPPALLRPGEEYNHTTWFKFSVA
What is the function of this protein?
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.  Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase).  Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1.  Also active on D-glucose although shows a preference for galactose over glucose.
What are the official names of this protein?
Galactose mutarotase, Aldose 1-epimerase.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_MYCTU
Sequence: MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIAPLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_STAA1
Sequence: MNIHEYQGKEIFRSMGVAVPEGRVAFTAEEAVEKAKELNSDVYVVKAQIHAGGRGKAGGVKIAKSLSEVETYAKELLGKTLVTHQTGPEGKEIKRLYIEEGCAIQKEYYVGFVIDRATDQVTLMASEEGGTEIEEVAAKTPEKIFKETIDPVIGLSPFQARRIAFNINIPKESVNKAAKFLLALYNVFIEKDCSIVEINPLVTTADGDVLALDAKINFDDNALFRHKDVVELRDLEEEDPKEIEASKHDLSYIALDGDIGCMVNGAGLAMATMDTINHFGGNPANFLDAGGSATREKVTEAFKIILGDENVKGIFVNIFGGIMKCDVIAEGIVEAVKEVDLTLPLVVRLEGTNVELGKKILKDSGLAIEPAATMAEGAQKIVKLVKEA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PROB_SHESH
Sequence: MNLSEIGYRRVVVKLGTSVLTSGSRQLDKAHMVELARQMAALMKAGVEVVLCTSGAIAAGREHLGYPELPDTVANKQLLAAVGQSQLILAWAQLFSIYGLHVGQLLLTRADLHDRERYLNARDSLNALLAQGIIPIINENDAVATNEIKVGDNDNLSARAALLCDADLLILLTDQRGLFDADPRSNPDAKLIKQVVNIDDSLRLLAGGAVSGLGTGGMATKLEAADIARRAGVEVIIASGHHPRVIQDAVCKESVGTHFTALENPLESRKQWILAGQATRGKLILDQGALNAVTQKGRSLLSKGIVRVEGKFERGATLHLVDSDGREFARGMSRYSAKDLHLIAGKHSDDIESLLGYDYGDAVVHRNDMVVL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARSR_HALSA
Sequence: MSSTERLQRYLTDERGGCGDEEVAQRLDELEELDAAAGGPALEADVGVLSALANETRYKIIRILHIAGEELCVCEFSPLLDVSDSAISHSLSQLTEAGLVTRRKDGKWRKYQTTMRGDALLVALNGSRR
What is the function of this protein?
Transcriptional repressor for the arsADRC operon.
What are the official names of this protein?
Putative arsenical resistance operon repressor ArsR.
Protein: FIS_PROVU
Sequence: MFEQRVNSDVLTVATVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAAQMMGINRGTLRKKLK
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: CHM1A_DANRE
Sequence: MDDTLFQLKFTSKQLERLAKKAEKDSKSEQAKVKKALQQKNVECARVYAENAIRKKNEGLNWLRMASRVDAVASKVQTALTMKGVAKNMTQVTKALDKALSSMDLQKVSAVMDKFETQVQNLDVHTSVMEDSMSSATTLSTPQQQVDDLILQIAEESGLEVEDQLSQLPAGASALGETSARAQEKEDQLSRRLAALRN
What is the function of this protein?
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, CHMP1a.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Protein: RIBBA_BACC1
Sequence: MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVAHNTDSHHTAFTVSIDHVSTTTGISAHERATTIREMLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVICEIINEDGTMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFHAIGYSNSLDTKEHIALVKGDISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANEKLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLEVIERVPLQMPAKEENKTYLQTKVNKLGHLLNL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: COAD_CALS4
Sequence: MRVAIYPGSFDPVTYGHIDIIKRGANLFDKLIVAVLLNPAKRPLFSIQERIELLKEVTKDIPNVEVDYFDGLLVEYAKKVNASAIIKGLRMVSDFEYEFQMALVNKKLNPSVETIFLMTSPKYGYLSSSLVKEIAQFGGCLSEFVPDIVAERLMEKFKKS
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM2_MOUSE
Sequence: MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542).  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).  Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219).  Permits the nuclear export of p53/TP53 (By similarity).  Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity).  Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity).  Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity).  Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity).  Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity).  Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity).  Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421).  Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (PubMed:14642282).  Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903).  Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903).
What are the official names of this protein?
E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2.
What is the protein family that this protein belongs to?
Belongs to the MDM2/MDM4 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Colocalizes with RASSF1 isoform A in the nucleus (By similarity). Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins.