PharMolix/UniProtQA huggingface dataset:
Protein: EFNB2_DANRE
Sequence: MGDSLWRYYFGVLVIACKVNLSRALILDSIYWNTTNTKFVPGQGLVLYPQIGDKMDIVCPRVEGGSMEGVEYYKLYMVPLEQLKSCQVTKADTPLLNCVKPDQDVKFTLKFQEFSPNLWGLEFFRGKDYYIISTSNGTMEGLDNQEGGVCKTKSMKIIMKVGQNPSDPISPKDYPTSYPPKHPDLGGKDSKSNEVLKPDASPHGEDKGDGNKSSSVIGSEVALFACIASASVIVIIIIIMLVFLLLKYRRRHRKHSPQHATTLSLSTLATPKRGGSGGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
What is the function of this protein?
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity).
What are the official names of this protein?
Ephrin-B2a.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: QUEA_BORAP
Sequence: MKTKEFHFNLPYSLIAQYPSEKRGSSRLMVLDPKLQKIYHENSVNNILKYINSDTFIVFNNSKVRKSRMYAESEMGSNVEFLILDRIGTDLFTALISKSKKQIVGNVYKFPEGLMGKILSKNSSEIVLKFNDDVREDYFEKHGFVPIPPYIKRDYDKIDEDRYQTIYSKYVGSAASATAGLHFSRDLFSAFEKNNIEYDFITLHVGLGTFLPVRSKKVEEHNMHFETFLIKDCVANRLENAKFLGKKVLSIGTTTLRALESSYDNKLKKFKTGQQSTNLFIYPGKNYCFKFVDMLFTNFHTPQSTLLMLVSAFAGKDFVFSSYEEGINKGYKFFSYGDAMLVLNHI
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_CHESB
Sequence: MAERHPERSTEAFFGRRRGKRLRSQQTAAVEKLLPRLKLDLSSPAPAALDSLFGKPLREIRLEIGFGGGEHLLNEIRRHPDVGFIGVEPFVNGMAKLVAALEGEAPPNLRLYDDDATKLLDWLPDSAISRIDLFYPDPWPKKRHWKRRFVNKANLDRFARVLCVDGQFRFASDIEGYVNWTLLACRAHPDFRWVAKSAEDWRHPYEGWPGTRYEAKAMREGRHPAYLTFVRV
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PEX12_ARATH
Sequence: MLFQVGGEGTRPTFFEMAAAQQLPASLRAALTYSLGVFALRRSFLHKILDYEDEFFAALMLILEGHSLRTTDGSFAESLYGLRRKSARLRLRKDSARKDSSEEVQHSGLEKRQRILSVVFLVVLPYFKSKLHAIYNKEREARLRESLWGAEDQGFDEADFFTGDDSIVSREPSGNEELSVRVQLATKIKKFIAVCYPWIHASSEGLSFTYQLLYLLDATGFYSLGLQALGIQVCRATGQELMDTSSRISKIRNHERERLRGPPWLKTVQGALLSCSYAVLDYAQTGLIAAVFIFKMMEWWYQSAEERLSAPTVYPPPPPPPAPKMAKEGIPLPPDRSLCALCLQKRANPSVVTVSGFVFCYSCVFKYVSKYKRCPVTLIPASVDQIRRLFQDT
What is the function of this protein?
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:16113209, PubMed:16813573, PubMed:17478547, PubMed:19594707, PubMed:20679226, PubMed:23336935).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity).  PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity).  When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Peroxisome biogenesis protein 12, Peroxin-12, AtPEX12, Pex12p, Protein ABERRANT PEROXISOME MORPHOLOGY 4.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: HSLU_THEPX
Sequence: MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTGVGKTEIARRIAKLVEAPFVKVEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVTEKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSEETEEESMQYKREEIRQKLRNGELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRILESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPIIEGCTVMTKYGPVKTDHILFIAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRILKEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLINQQSEDIGARRLHTVMEKLFEELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH25H_HUMAN
Sequence: MSCHNCSDPQVLCSSGQLFLQPLWDHLRSWEALLQSPFFPVIFSITTYVGFCLPFVVLDILCSWVPALRRYKIHPDFSPSAQQLLPCLGQTLYQHVMFVFPVTLLHWARSPALLPHEAPELLLLLHHILFCLLLFDMEFFVWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGYNFPWSTHRLVPFGWYGGVVHHDLHHSHFNCNFAPYFTHWDKILGTLRTASVPAR
What is the function of this protein?
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097).  Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity).  May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097).  As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2).  Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication (PubMed:33239446, PubMed:32944968).  In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity).  Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity).
What are the official names of this protein?
Cholesterol 25-hydroxylase, Cholesterol 25-monooxygenase, h25OH.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS19_PSEPF
Sequence: MPRSLKKGPFIDLHLLKKIEVAAEKNDRKPIKTWSRRSMILPQMVGLTIAVHNGRQHVPVLVNEDMVGHKLGEFAGTRNYRGHVADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: POXH_PENOX
Sequence: MSTTTTMRAWTYMQSGLPSQTIVLDDEAPSPSAAELGPDELLIAVNYVAMNSGFTTLMRSLPPQPYSLPHIYNRQKRLGVPEFEFSGRILAVGSAIPSTRPDLQPSTLVLGCCAAKRVFIEGKGALAERVIAPAAQLIPLRPLSTVTTQDDESPGPDPAAPPISLLEASGLSACGCTAVQVLDLTKLVAGDKLFVNGGSTSVGMLTIQVARQVLGQTGTIIASGTDTTLIRSVGADDVIDYTAQRPLHEFLRTHHADRPFDAIIDCVGVAELYTHCEPYLAPGKLFINLGAMTAKPTFWGLLSFVWNQHMAPLWPVVLGGVPRSYQFYSARPNRETLGRVMRLVERGELRMVVDSVWEMRDAKMAYKRMESKRAKGKIIVRVQEE
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
Trans-enoyl reductase poxH, Oxaleimides biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: HOS1_ARATH
Sequence: MDTREINGFASAARSISLPTQPNYSSKPVQEALKHLASINLRELCNEAKVERCRATRDLASCGRFVNYVLNPCGHASLCTECCQRCDVCPICRSTLPKFGDRLRLRLYYECVEAGLISRTHEEASQDSDEDEHQLAADVHRLYSLFDVAMNNNLISVVCHYITNVCMDETAVSSDPVIAFLLDEVVVKDWVKRTFRSTLAELQEIYNLETKEMQAWLDKLLRCSKQVAGICSVLEVMESAFKGSVSPQLQDVQTLRENIGKTKQHLDIMVWCIRHGFLDDVRSRYSNFTSWNALVGERKSNAVKRAWPDAVDQSSDCSVQSASLFIEDALENLEREPEYSQEIGADLEVGRLQKDKRSFLRSKIEGTSGSYPFENLRTAADMLFLHGGSDLVVAKQAIFLYYLFDRHWTTPEKYWKHTIDDFAATFGITRHSLLESFVFYLLDDHSEEALQEACRILPEICGPETYPKVAQVLLERDNPETALMVLRWSGRDGVSELVSIGEAVTALRVRVECGLLSEAFTYQRTLCLKVKENNLKNGAVKHASDDLDIWSWTEWMEILVNEFCCLSIRRNLVDRIIELPWNPDEEKYLHRCLLDSATDDPSSAVGSLLVVFYLQRYRYIQAYQVDLRLQKIEEAFVSDNQIGEEVMFRMRSQSHWRKELVDRAIDILPVIQQQQVRSGQFSEMEDASEGAKKSDLPDAPDMITSSVPFATTNSVFLQSANNARAREPVANNGSPFQPGHMIGNASHDLSHGRLFTNANRGQKSEVRSVTKNLKFGEMSTPFKDLNRARGNSQLQGKRTEESSPEVNVDRYIENNMSSPYLRRITANNPVTVKSSSNHLNGSSQKPESTFFGTRMQPDKDNFVDLDDPMDMSSSLKDNNNNVLATESRNNSGGLRWRSDETSDDEDELTSFGSMPVKGRRRRRFAAR
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1.  Acts as a negative regulator of cold signaling pathways (PubMed:16702557).  Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable).  Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels (PubMed:22960247).
What are the official names of this protein?
E3 ubiquitin-protein ligase HOS1, Protein HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1, RING finger protein HOS1, RING-type E3 ubiquitin transferase HOS1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear after cold treatment. Cytoplasmic when plant are grown or returned to normal growth temperatures.
Protein: HIS8_MYCSK
Sequence: MTVGERITLADLPLRDDLRGKSPYGAPQLQVPVRLNTNENPHPPSQALVDDVTRSVGEAAAELHRYPDRDAVALRSDLADYLNLRTGVELSVENLWAANGSNEVLQQLLQAFGGPGRSAIGFVPSYSMHPIIADATRTEWLQALRADDFGLDVDTAVREIAARRPDLVFVTSPNNPSGQSVPLEDLRRLLDAMETGILILDEAYGEFSSQPSGVALIDQYPTKLVVSRTMSKAFAFAGGRLGYLVAAPAVIEAMLLVRLPYHLSSLTQAAARAALRHADDTLASVATLIAERDRVANGLSQLGFRVVPSDANFILFGEFADAPATWRRYLDQGVLIRDVGIPGYLRTTIGLAEENDALLTASARLVETELAATLGAL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: FETP_VIBCH
Sequence: MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: BCHJ_RHOCB
Sequence: MSGAAPAPQDDEPRIGPNAILQTIGVLDRHLGRAERDRVMRLAGVPVPPPDSGMLPESQCRAVHQALRVDQGEAAEGLLWLSGLATGDYILANRIPGFAKAIIRVLPGFLGARLLAAAITKHAWTFVGSGRFRVESFRPLTFRIDDNPLRADAAERPSCFWHAAVFERLFGTLVWPEVTVEEISCASVSGGPCLFVLHPKGKKTAMPSSVHSG
What are the official names of this protein?
Bacteriochlorophyll synthase 23 kDa chain, 4-vinyl reductase.
Protein: MTRB_GEOSE
Sequence: MYTNSDFVVIKALEDGVNVIGLTRGADTRFHHSEKLDKGEVLIAQFTEHTSAIKVRGKAYIQTRHGVIESEGKK
What is the function of this protein?
Required for transcription attenuation control in the Trp operon.  This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination.  Binds the leader RNA only in presence of L-tryptophan.
What are the official names of this protein?
Transcription attenuation protein MtrB, Trp RNA-binding attenuation protein, TRAP, Tryptophan RNA-binding attenuator protein.
What is the protein family that this protein belongs to?
Belongs to the MtrB family.
Protein: LGT_RHOBA
Sequence: MEVARTVRIPHAFDGLTLSRQATMRRTLFLIPHEFAGWPIFGIGWALLFLLIAVLAYVGWESRRGGLGASTAIRQIAGFAVMAAVILVVVVPRTELVNTLGDPVGVAVRGYGMFLMLAAIASVGLAAWRAERAGLGADSILQLAPWTFIGGLLGARVFYVTQYYEDFLRPTWGETLMAMAALNQGGLVVYGGFIGGFIASLIALKRHQTPIWRIGDVIIPCVFVGLLFGRLGCLMNGCCYGGACEAGPLAVQFPAGSQVHAEQLLSGELLGIEGHPVVSDEEPPAGQSQMVVDSVRPDSLANQAGVKKGETLTIALDPSYRDQVPLDRPAEEALPGVVVLRDDEVVARFSPRDLPSIADPVWGTQIISSVFAAIMFVVLLIVERILHRPSKQTDDAVTERAITGGRRPGVLMLVGFIAYGVLRIVLEWIRVDEKGQFGTSLSISQWVSLVVIAASLVTLFIRWRGVDSTSEQTPGGGNTNVVGGSDAAAAGL
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURC_RUBXD
Sequence: MKVHMIGVGGAGMSGIAEVLARRGHEVTGSDLKESPYTRRLAAAGVKVYIGHEARQVGDAEVVVISTAIPKTNPELLEARRRSIPVIPRAEALARILAEGRGIAVAGTHGKTTTTSMIAHSLRALGENPTALVGGELNDIGSNVIFGREDLIVAEADESDRSILRLHPQAAVITNIEYDHPDFYASLEEVVETFARFVAGLPPEGHLVLCADDPRCRRLAELAPCPVTTYGLSGGELRARVLSPGSYLLFEGARKRGEVSLGVYGRHNVLNSLAAAGIARWLGHDPLEAARTLGSFGGVRRRFQLKGERSGVRVVDDYAHHPTEIMAILDVARATAAPEGRIIAVFQPHRYSRTRKLYREFGRAFGRADAVVVTEVYGAGEMPQPGVSGKLVVDAICETSDRPEVYYVPDQEALPEVLRMISGPRDTVITLGAGDISRAGEELLARL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_ANAD2
Sequence: MAKFDVYDLSKKKVGELDLADAVFAGEVNEHLFYEVVKAKLASDRSGTHAVKNRSLVSGGGKKPWKQKHTGRARQGSTRASQWVGGGKAMGPKPRDYSYDVPKKVRKAALRSALALRSKDQKLVIVQEWKPGAPKTAAAAKVLSALGAKKALVVDDAANLALAKSVRNLHGSDFLAVEGLNVYDILRHDALVLTADTAKKLEASLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RMT2_CRYNB
Sequence: MDMDSAHLDSSLLTLAFRLIKAAQTAAPSVLADLLAEGAPAWFQDDDLGWSCLHYAAERKEPECLEVLLQGGAVWNAVDKWGRTAGEICLSLGDEEGWSIIRNEGIRSEDKTSAGDNLVFLKSKLTWDVGKDGKERVLDADGNGVMMGWEEPLSYCIVVEHVKRLTEEHPKAELGAEGMSILNVGFGLGIVDRLFQECDPKPSHHTIIEAHPQVLEYIHKKGVHLLPNVRILQGRWQDWLLDGEKVGDVLSGTPDGMGFDAIFVDTFAEGYEDLKAFFEVIPDILNADNGRFSFWNGLGATNPTIYAVSSSLAELHLEDVGLQVEWHDVLIPESMREEVWKGVRRRYWDLPGYRLPIAKMSLI
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VE2_HPV35
Sequence: MMETLSQRLSVCQDKILEHYETDSTCLSDHIQYWKLIRLECAVFYKAREMGIKTLNHQVVPTQAISKAKAMQAIELQLMLETLNTTEYSTETWTLQETSIELYTTVPQGCFKKHGVTVEVQFDGDKQNTMHYTNWTHIYILEDSICTVVKGLVNYKGIYYVHQGVETYYVTFREEAKKYGKKNIWEVHVGGQVIVCPESVFSSTELSTAEIATQLHAYNTTETHTKACSVGTTETQKTNHKRLRGGTELPYNPTKRVRLSAVDSVDRGVYSTSDCTNKDRCGSCSTTTPIVHLKGDANTLKCLRYRLGKYKALYQDASSTWRWTCTNDKKQIAIVTLTYTTEYQRDKFLTTVKIPNTVTVSKGYMSI
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: DSBD_VIBVU
Sequence: MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDWQVKEGYYLYQQRLSFSAENVVLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPGAKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMPTQTANPLDTSTPQPLTQQDQLASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQGMALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLNNLSNKQQGGSSAGVFAMGAISGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGMGIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFLLERILPEMWSTALWSALGIAAFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIRNVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTRNQAQDIELLQAQQVLGLPTIDFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1725_STRP2
Sequence: MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESNSALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSNVNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDDVEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKLYSVLEDDEDVQKIYTNVDGF
What are the official names of this protein?
Probable transcriptional regulatory protein SPD_1725.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_DESRM
Sequence: MITEAIQKVVAGINLSEAEAMETMQEVMEGKATQAQIASLLTALHLKGETVPEITGFARTMRTKVIRVQTKRRNLVDTCGTGGDGANTFNISTACAFVLAGAGLPVAKHGNRSVSSKCGSADVLEQLGVFVQLTPEEAGLCLDQVGIAFLFAPLLHGAMKYAAAPRKEIGIRTVFNILGPLTNPAFAENQVLGVYSSDLAPVLAQVLANLGTKRSFVIHGCGGLDEISLAGEALVYEVKDNQVKEMIIDPMDYGLDRAPISALAGGDAKRNARMIKNILSGAPGPQRDTIIINAALGLIAGGLVRDLAMGIRLAEQIIDEGYALKKLNLLVEFSQTLVGRRSAAL
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: ACKA_CALS8
Sequence: MKVLVLNSGSSSLKYQFIDTETEVALCKGVVDRIGLPGAFIRHQKNGQEIIKEQEVKDHNVAIKLVLEMLTHPQMGIIKSMDEIDAIGHRVVHGGEYFSDAVIVNEEVKKAIRECIEFAPLHNPANLMGIEACEKEIPGKPNVAVFDTAFHQTMPKYAYMYSLPYEVYEKYKIRKYGFHGTSHKYVAIKAAEYLKRPLKELKLITCHLGNGSSVCAIKYGKSVDTSMGFTPLAGLAMGTRSGTIDPAVILYLMEKENMDVKQMNDLLNKKSGVLGISGVSSDFRDLEKAANEGNERAQLAIDMFCYRVKKYIGEYAAVLGGVDAIIFTAGIGENNPIVREKCVTDLEYMGVLYDKQKNFNAEKGKVFEINKPESKVKVLIVPTNEELMIARETKRLLEK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.