PharMolix/UniProtQA huggingface dataset:
Protein: PMK1_CAEEL
Sequence: MFPQTTMDHILHPTPREGYYVVELNRSVWVVPNYYINLTPIGTGAYGTVCAAECTRSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCMCHENIIDLLDVFTPNENVNDIEDVYFVSMLMGADLSNILKIQRLNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEEARNYIRNLPKMTRRDFKRLFAQATPQAIDLLEKMLHLDPDRRPTAKEAMEHEYLAAYHDETDEPIAEEMDLNDDVRADTIDEWKKIIWEEISDFQKNVAFADEEEDEEKMES
What is the function of this protein?
Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898, PubMed:22308034, PubMed:20369020).  As part of a MAP kinase signaling pathway, plays a role in modulation of lifespan and immunity (PubMed:29748542, PubMed:12142542, PubMed:20369020, PubMed:22216003).  Phosphorylates skn-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress (PubMed:16166371).  Probably by activating skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection (PubMed:22216003).  Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment (PubMed:16166371, PubMed:25204677).  Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase which regulates pathogen resistance and responses to oxidative stress (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898).  Required for expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury (PubMed:18394898).  Involved in resistance to the nematotoxic C. cinerea galectin (Cgl2) (PubMed:20062796).  May play a redundant role with other MAP kinases in susceptibility to anoxia, downstream of tir-1/nsy-1 (PubMed:21212236).  Phosphorylates transcription factor rnt-1 during oxidative stress which results in rnt-1 stabilization in the intestine (PubMed:22308034).  Phosphorylates transcription factor atf-7 during pathogen infection resulting in modulation of target genes (PubMed:20369020).  Probably downstream of nsy-1 and sek-1, involved in germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:19497412).
What are the official names of this protein?
Mitogen-activated protein kinase pmk-1, Stress-activated protein kinase pmk-1, p38 MAP kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in nucleus in response to heavy metals, such as cadmium.
Protein: RDGC_XYLFM
Sequence: MFFRNLTLFRFPTSLDFSQIDSILPNARLRPVGPLEMTSRGFISPFGREEQEVLNQRQGDFLWLTVGSEDKILPASVVNDLLTRKCSEIEEKKGHPPGGRERKRIKDDLIHELLPRAFVKNSRIDAMLDLRYGYVAVDTASRKAAETVISEIRDLLGSFPALPLNAEISIRSMLTSWIAGEPLPEHLNLGDECEMKDATEGGAIIKCQHQALRCEEIDKHLEVGKQVSKLALILDDHVSFVLGDDLVIRKLKFLDGMLDQLEHSDTDGIRAELDACFALMSAEIRRLFLLLEVPLKLSKANN
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: LPXK_PSEPW
Sequence: MALADRLLAAWYAGHPALALLRPLEALYRRVVTRKRARFLSGESASYRAPVPVIVVGNITIGGTGKTPMILWLIEHCRRQGLKVGVVSRGYGAEPPRLPWRVEAIQSAEQAGDEPLLIVQRTGVPLMIDPDRSRAVQALLASEPLDLILCDDGMQHYRLARDLELVLIDAARGLGNGRCLPAGPLREPAERLQEVDAVLFNGASADRPEGFAFHLQPSALVNLRTGERRALDFFPAGQRLHAVAGIGNPQRFFNTLLGLNWQPVPHPFADHAQFSAQSLAFSPSLPLVMTEKDAVKCRAFAADDWWYLAVEALPTPAFCGWFDSQLQRLLPGHRTP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MTNC_PSEA8
Sequence: MTIKAILTDIEGTTSAVSFVFDVLFPYAARHLPDFVREHAGETEVAAQLAAVRAESGEADADVERVIAILLQWIAEDRKVTPLKALQGMVWAQGYRDGQLKGHVYPDAVQALREWKARGLDLYVYSSGSIQAQKLIFGCSEAGDLGSLFSGYFDTTSGPKRESASYARIAGAIGLPAAEILFLSDVVQELDAARDAGMRTLGLAREGGSLDGHPTVASFADILVE
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: MLRA_SALTS
Sequence: MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKVLLSSDSSEQPNGWREQQEILLHYLQSSNLHSLRLWVKERGQDYPAQTLTTNLFVPLRRRLQCQQPALQALLGILDGILINYIALCLASARKKQGKDALVIGWNIHDTTRLWLEGWVASQQGWRIDVLAHSLSQFRPELFDGKTLLVWCGENQTLAQQQQLLAWRAQGRDIHPLGV
What is the function of this protein?
Transcriptional activator of csgD, which is required for production of the curli (AgF).
What are the official names of this protein?
HTH-type transcriptional regulator MlrA, MerR-like regulator A.
Protein: RNFD_ERWT9
Sequence: MAFRIASSPYTHNRRSTSRIMLLVLIATLPGIAAQWYYFGWGNIIQVLIASVAALVAEAAILHLRKQPLAETLKDNSALLTALLLGVSIPSLAPWWMVTIGTVFAIIISKQLYGGLGQNPFNPAMVGYVVLVISFPVQMTSWLPPVGLQGITPSFADTLSMIFHLHTLDGHTMQQLQVGIDGISQATPLDHFKTGLRAGHSAEQLLAQPTYSGVIAGIGWQWVNVGFLLGGVFLLFTRCIRWHIPVSFIASLAFFATLGWLLSPQSLVTPMIHLFSGATMLGAFFIATDPVTASTTNKGRLLYGVLIGLLTWLIRSYGGYPDGLAFAVLLANICVPLIDYYTQPRVYGHRKGK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHAA2_MYCSJ
Sequence: MTPTPGEADLTNTPAPRARRSVLSRGSWSETARIAGILRKETVGGAVLLVASAVALVWANSPWAESYFALRDLKIGAEPFGLHLNLTLGTWAADGLLAVFFLVVGLELKREFVAGDLRDPARAALPMAAAVGGMVVPALIFVAVTAPVGDGATRGWAIPTATDIAFAVAVLAVISTHLPAALRTFLLTLAVVDDLLAVTVIAVFYTDEINLTALGLSIVPLALFALCVQRRIRSWWLLLPLGVATWVLVHESGVHATVAGVLLGFTVPVLRSVAAGGPEAGPGLAEHFEHRLRPLSAGVAVPVFAFFAAGVAIGGVSGLTRALSDPITLGIILGLVVGKPVGIFLTTRVLTAVTRANLDDALRWIDVFGVALLAGIGFTVSLLIGDLAYGLGSDRDDFVKVGVLTGSLVAALIAAVLLRVRNRHYRAVWLQETADTDRDGVPDVYQSQRD
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NCAP_BDVV
Sequence: MPPKRRLVDDADAMEDQDLYEPPASLPKLPGKFLQYTVGGSDPHPGIGHEKDIRQNAVALLDQSRRDMFHTVTPSLVFLCLLIPGLHAAFVHGGVPRESYLSTPVTRGEQTVVKTAKFYGEKTTQRDLTELEISSIFSHCCSLLIGVVIGSSSKIKAGAEQIKKRFKTMMAALNRPSHGETATLLQMFNPHEAIDWINGQPWVGSFVLSLLTTDFESPGKEFMDQIKLVASYAQMTTYTTIKEYLAECMDATLTIPVVAYEIRDFLEVSAKLKEDHADLFPFLGAIRHPDAIKLAPRSFPNLASAAFYWSKKENPTMAGYRASTIQPGASVKETQLARYRRREISRGEDGAELSGEISAIMKMIGVTGLN
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  Plays a critical role in the nucleocytoplasmic transport of viral RNP by interaction with other viral proteins.  The nuclear export signal is masked by the interaction with the phosphoprotein P.  Delays the host cell cycle progression by interacting with the host CDK1-cyclin B1 phase in late G2.  Inhibits host NF-kappaB activation.
What are the official names of this protein?
Nucleoprotein, N protein, Nucleocapsid protein, p38, p40.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host cytoplasm. Note=Shuttles between the host nucleus and cytoplasm.
Protein: MNMG_BACCN
Sequence: MGYNAGSYDVIVIGAGHAGCEAGLAAARMGSKTLMLTINLDMVAFMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADKFLYQHELKKTIEETPNLTLRQGMVERLIVEDGVCKGVITQSGAEYTAKTVVITTGTFLRGEIIMGDLKYSSGPNNQQPSITLSEHLEELGFELVRFKTGTPPRVNSNTIDYSKTEIQPGDDQPRAFSFETTKFILDQIPCWLTYTSEETHRLIDKNLHRSAMYSGMIKGTGPRYCPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQREMLKTIPGLENVEMMRTGYAIEYDAIVPTQLWPTLETKKIKNLYTAGQINGTSGYEEAAGQGIMAGINAACRSLGKKEVILGRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTEIGHEIGLIPEERYERYSQKKEQIEQEKARLEGIIIKPRPEVQELIRSVGGSELKDGIRASDLLRRPEMTYEHIRLLAPSELEINDEVAEQVEIQIKYEGYIEKSLQQVERMKKMESKKIPVDIDYDAISGIASEARQKLKEVRPLSVGQASRISGVNPADISILLVYIEQGKIARVSNQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_METFK
Sequence: MNLPKRIFIKTFGCQMNEYDSSRMLDMLQAAEGMQTTDNPEEADVILLNTCSVREKAQEKVFSHLGRFAPLKEKNPDLVIGVGGCVASQEGESIVARAPYVDVVFGPQTLHRLPDMIESKRRTGISQVDISFPEVEKFDHLPPPRVEGAAAFLSIMEGCSKYCTFCVVPYTRGDEVSRPFDDILTEAIQLAEQGVKEITLLGQNVNGYRSETADGEMADLALLIEYLAEIPEIERIRYTTSHPNEMTPALIDCYARIPKLVSHLHLPVQAGSDRVLMNMKRNYTVLQYKSIIRKLRAARPDICISSDFIVGFPGETEQDFEATMKLMRDVGFDFSFSFIYSPRPGTPASYLPDDCSPEEKQSRLSRLQALNEAQGKAISASMVGSIQRVLIESVSAKRADELAGRTDNNRIVNFPGDTALINQFVNVRITEALSHTLRGELV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_STRS2
Sequence: MATIKEVTALLAQVDSLDSPVWDQLAQDERAGVQAAIKKRRKELEKEAVEDARLEAMLFYEKSLYENGVEFIAGIDEVGRGPLAGPVVAAAVILPKGCKIRYLNDSKKIPKSKHEAIYQEVMERAVAVGVGIKDAALIDEVNIYEATKLAMLEALGKLSQKPDHLLIDAMKLDTPIPQTSIIKGDANSLSIAAASIVAKVTRDKMMADYDKEFSGYGFAKNAGYGTTEHLEGLNKLGITPIHRKTFEPIKSMVAGGN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCM1_CAEEL
Sequence: MKSRFLLKIFIFLAVFGVDSVRAADCTEKTFKTGTVCVCSLDSCDEIPPLDITMGQAALYTTSHTGARLHRDVIYATDTEPFGTLHMTIDSSKKYQTIQGFGSTFSDASGANLKSLPDKLSDLIMKQYFSDTGLNLQFGRVPIASTDFSGRVYSYNDVANDYSMQNFNLTKEDFQWKIPYIKNAQKYNPNLKLFAAPWAAPGWLKTTKEMTGPGALNGKAGDNYHQAYAKYFVRFLEEYGKSGISFWGLSTQNQPTLGSDKKNKIQSTLFTAETQRDFIKTDLGPALAASSSGKDVKLLILDDNRGNLPKWADTVLNDMDAAKYVGGIGVHAYQDGETDNHLDETHKKHPNFFILGTEASEGYGSKDTHVDYGNWDRAADTASDILDNMNNWMTGWTERNLILDALGGPSWVSDYTDAPVIAFPAMAQFYKQPMFYAIAHFSHFIKPGAVRIDHSLNVIELEVETTAFLNPDGSKVIVMLNKGSLVSTEHTVVVQDAADSRNHYHFTLPHRAITTLYIQTSQF
What are the official names of this protein?
Putative glucosylceramidase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
Protein: NU2M_ALBCA
Sequence: MTLQSVLLGAMIILGPILSMTSSNWIIIWIGLEISLLGFVSYYMLMKKIMSGEGIMMYFLIQSVSSTVMLLNGLYIFVNHASSYIYLFIFITMLMLKIGMFPLHFWIIPVYSKLSYLNIGIVGLLLKIVPMWILMHMGCITSEMLNLITMLSVTSMLFGALIGMNLSKMRMVLGASTITHNGWLGMSCISGSLFKYFITYGFSLVILLVFLYLGDKMSISLSLLSLSGLPPFMLFIGKINVLLMMMETNLWFIVLVFAILSAVISLVYYLKFSVMFFMNMKNNYLKHYKMAMFLLVNVTFGMLLFLT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VP4_FDVS
Sequence: MLNVNANSLIYPFSGQITDIRKNQFIPTSKFINTVINEPIFLTKQKVRTKPGTSHAPRKILEVNPSWNNTFFNWNTALRNPSTVLPSFIYERTESSTSKKSHDQETNQVLINAEILNRKLPQFIKQKFGYIDKRKGGYVNQFGFWALLYSEFCLKLNVPIEYYISMLNLKTQDNNIFLREYNEVEYALRYLVRFDELIYTNGKGRKFIKLPSSGKLDFSVDVEEIENVIGCDLHYWTLWPLSNTYTVQGSGILNHGNIVRGICEFTNELVAAHYYPTYFYEHYLYFEDVSNLIKHQIYNVIRTYKAQLKLQDNLGTNRLERRGYYLTMFCPFFEKYKYSVVDQFGELYLYLNMFGALPFDSADSKSIPKTYNDFDIYYQDRFKNFKDFGYVTYNTTIPNEYKRRNLGPYQLFFTYQQMFDLIQTISTNVNLMYNFKILGFNMMDISNINEIDTNVTSVCRNIEYPLGPSLHLNNLEAIPPNLLELANNVTMQFNSNFLSPYSMYTLPLMRSSAERLIQEDGLRLAVFRLSTAHRKQLKTLQKQVLDPKVLFDRFIRPNLIRCQIPKFEFLFWITYCVDEFPMYTISSTGDLDVTPLTSSDEKRKSSVTNNSSFKLLCMAFQFLSEFGIREIVKPNSVLFLGAKNEPVGDMLRRLSHGLWSVQRVGADAEYPSKKANINNVNLKNTYDLVISDMDQSTGTTVEAISALCVSQLKKCIECFNRRLVFKIQYGLFHTLCAIRDCLIECGQDYAGQNLYFNMKIVRSCWSKVGSMELFLILDKTKTEHELYTVDQLRAVVNSFGFSETNTVFYTYMGTPSRYQLNDLNCKIFSVDVTVNEFSDVLSTFMNLSNCVSYGALKNEAYVDTLTIFGATNIQRIGLFMRNKQIYKSLALDGKDHRPEGIFDPRKCFVIPGAREVLILSDAQRMKAWKILKKMHFDRAVLDTSLTIYDIGCRDFECAYLAVMDEDTILPYVGIDKSTILDVKRNLTIERREVNRTELYRLATLGHVFVYNSYFMDFPTRAKLEEELNYLYDNLVLKGVMLMSFYCLHDELLPVLKDHGFVDISSKDVKENKFSFGRYHGFGTVDYNFMLEWLTKMSQKFEVHTVILSASDISFSCVMHGNAINLDSIYFAPIFNMVQPCFLIKNK
What are the official names of this protein?
Uncharacterized protein VP4.
Protein: ATPF_NITSB
Sequence: MKQKLLMLLLLGSVSLFANEAAASGGTDIIPRTVNFLIFAAILYYLAAEPIKRFFQERKEGIAKRLEEVEAKLKEAKEEKAQAEAELKKAKELAQEIVETAKQEIEILTKEIKEQAKQEIEMLEKSFEESMELEKRKRVRAITKEVLEELFEEKALELEKEKFVNLIVKKVA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: 3NOJ_DENAN
Sequence: LECHRRGSFISDGKITCSAKKTFCCKMYEKIFGIYWYGCAKTYTEKNTWNVYSKCCTTNLCNT
What is the function of this protein?
Activates bacterial pH-gated potassium channel KcsA by binding to its extracellular domain, probably at a site different from channel inhibitors.  Increases both mean open time and open probability of KscA.
What are the official names of this protein?
Toxin Tx7335.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group XIX sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FABZ_HERAR
Sequence: MKTLDINQIKQYLPHRYPMLLVDRVLTWESGKSITAIKNVTANEEFFNGHFPHKPVMPGVLMIEALAQTAALLSFLTMGQKPDDNSVVYFIGIDGARFKRPVEPGDQLKMEVEILRNARGIWKYKATGSVDGQLALEAELMCTMRTINDAGSTAGQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACEK_YERPP
Sequence: MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCLTSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAS4_HORVU
Sequence: MDGQSEEVDALVQKITGLHAAIAKLPSLSPSPDVDALFTDLVTACVPPSPVDVTKLAPEAQAMREGLIRLCSEAEGKLEAHYSDMLAAFDNPLDHLGVFPYYSNYINLSKLEYELLARYVPGRHRPARVAFIGSGPLPFSSYVLAARHLPDTVFDNYDLCGAANDRATRLFRADKDVGARMSFHTADVADLTDELATYDVVFLAALVGMAAEDKAKVIAHLGAHMADGAALVARHGARGFLYPIVDPQDIGRGGFEVLAVCHPDDDVVNSVIIAQKSNDVHEYGLGSGRGGRYARGTVVPVVSPPCRFGEMVADVTQKREEFANAEVAF
What is the function of this protein?
Synthesizes nicotianamine, a polyamine that is the first intermediate in the synthesis of the phytosiderophores of the mugineic acid type found in gramineae which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.
What are the official names of this protein?
Probable nicotianamine synthase 4, HvNAS4, S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the nicotianamine synthase (NAS)-like family.
Protein: LEUC_THET8
Sequence: MGKTLYEKVWEAHEVRKLKNGQSQLFIDLHLLHEVTSPQAFGMLKDLGLRVRYPHRTFATVDHIVPTHDRTEPFQDPLAQSMLEALRANTREHGITFFDLGSGNQGIVHVIGPQLGLTQPGMTIACGDSHTSTHGAFGAVAFGIGTSQVRDVLATQTLAAQKLKVRRINVEGRLAPGVYAKDVILHIIRHLGVKGGLGYAYEYGGSAVEAMDMESRMTLCNMSIEGGARIGYVNPDETTFQYLEGRPYVPKGSEWEEAKRRWLAWRSDPDASYDDVVTFRAEEIAPTVTWGITPGQAIPIDGRIPLLEELPEEERPVAEEALAYMGFRPGQPIKGVPIQVAFIGSCTNARLSDLREVARYLKGHKVKKGVRALVVPGSEWVARKAEEEGIAEVFREAGFEWRMPGCSMCLAMNPDRLEGDELCASSSNRNYKGRMGSPRGRTVLMSPLMVAAAAVAGEIADAREVFGLAGVR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PSD_CLOK1
Sequence: MIKYFNRKTKQYEIEQVAGEKYLKWTYCSPIGMKLLELIIKKKIFSKLYGYFCNSRYSKKNIYPFIKNFNINMDDYIEQTDNFKCFNDFFSRALKNNSRSIDRDEKVLISPGDGRLQVYENIDLNKIVQIKGFTYSLYNLINDIEIAKRFYKGTCLILRLCPTDYHRFHFIDYGICDFTHKIKGNYYSVNPIALRNISNIFCRNKREWSIFHSKNFGDILYVEVGATCVGSIVQTYFPGKHVSKGDEKGYFKFGGSTIILFFEQNKIRIHKDLLEQSNMGYETKVLMGESIGIKYQ
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PSB2_HALMA
Sequence: MHDPENRLTDAYEPEVGNLPNEDSGRDEENVVKTGTTTVGLSTEDGVIIATDRRASLGGRFVSNKQVQKVEQIHPTAAMTLVGSVGGAQSFIRSLRAEADLYEVRRDEPLSIHALATLAGNFARGGPYFAINPIVGGVDEEGSHVYSVDPAGGVLEDDYTVTGSGTMVATGTIEGQYDHGMSLSEARDLAIRAVNAAAERDTGSGNGVVLAEITDEGVEIDAFDDYESAE
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 2, 20S proteasome beta subunit 2, Proteasome core protein PsmB 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SYNPW
Sequence: MAKGGGKKSAAAARAAANRLLADNRLARHQYDILETLETGIELVGTEVKSIRAGQANLRDGFCLIRNGELQLHNVHISPHTHASGYFNHDPLRVRRLLAHRREIDKLRGQLDQKGLTLIPLNLHLQGSWIKLTLGLGKGRKLHDKRAAEKDKQIKKETRAALSRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: VATE1_HUMAN
Sequence: MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:32001091).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).
What are the official names of this protein?
V-type proton ATPase subunit E 1, V-ATPase subunit E 1, V-ATPase 31 kDa subunit, p31, Vacuolar proton pump subunit E 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Protein: RL9_LEGPL
Sequence: MEVILLEKVRNLGNLGDKVHVKSGYGRNYLIPQNKAVFATEQNIELFEKRRAELEKKAQQNLANAEQRAAKLNDTTIVISAMASDEGKLYGSVGVNEIKDALIEKQIEISKREIVMPEGPLHSIGNYVVEVHVHSDVVANLQVEIIPAK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.