PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_STRGG
Sequence: MAARNKARKRAFQILFEADQRGESVQSVLADWVRLSRTDDRQPPVGEFTMELVEGYAQYADRIDDLIVTYAVDWEIDRMPVVDRSILRLGAYELIWMDGTPDAVVIDEAVQLAKEFSTDDSPSFVNGLLARFKDLKPNLRREQ
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RSMA_BACCZ
Sequence: MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILDETLAPYGNVTVINKDVLKADVHEVFSEQFEEGQDVMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDRLAAKPGTKEYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMNNLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_KLEP7
Sequence: MANKPTPEELKNGLSEMQFYVTQHHGTEPPFTGRLLHNKKNGVYHCLVCDAPLFNSQTKYDSGCGWPSFYEPVSAEAIRYLTDNSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLSFTDEQNGEQIKG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: TPX_STAAC
Sequence: MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSDASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: FPG1_MYCTU
Sequence: MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLTARLRGARINGTDRRGKYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRISALLDDGTVLSFADQRTFGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLRRKHSELKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMREALAKGGTSFDSLYVNVNGESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCPRCQPRPRK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) when paired with C, G or T, as well as methyl-faPy (formanidopyrimidine residues) in poly(dG-dC) and spiroiminodihydantoin:C base pairs.  Unlike its E. coli ortholog has no activity on 8-oxoG:A.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.  Cleaves ssDNA containing an AP site.  Complements the H(2)O(2) sensitivity of an M. smegmatis fpg disruption mutant; upon expression in M. smegmatis excises 8-oxoG from dsDNA.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase 1, Fapy-DNA glycosylase 1, DNA-(apurinic or apyrimidinic site) lyase MutM 1, AP lyase MutM 1.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SEM3E_HUMAN
Sequence: MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTLDS
What is the function of this protein?
Plays an important role in signaling via the cell surface receptor PLXND1.  Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections.  Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix.  Regulates angiogenesis, both during embryogenesis and after birth.  Can down-regulate sprouting angiogenesis.  Required for normal vascular patterning during embryogenesis.  Plays an important role in ensuring the specificity of synapse formation (By similarity).
What are the official names of this protein?
Semaphorin-3E.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_BACMK
Sequence: MSTHVTFDYSKALSFIGENELTYLRDAVKVTHHAIHEKTGAGNDFLGWVELPLQYDKEEFARIQKCAEKIKNDSDILLVVGIGGSYLGARAAIEMLNHSFYNTLSKEQRKTPQVLFVGQNISSTYMKDLMDVLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEEKYGKEEARKRIYATTDKARGALKTLSDNEGYETFVIPDDVGGRFSVLTPVGLLPIAVSGLNIEEMMKGAAAGHNDFAKSELEENPAYQYAVVRNALYNKGKTIEMLVNYEPALHYFSEWWKQLFGESEGKDQKGIFPSSANFSTDLHSLGQYIQEGRRDLFETVLKVGKSTHELKIELDDNDLDGLNYLAGETIDFVNTKAYEGTLLAHSDGGVPNLIVNIPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEERLK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TI214_BARVE
Sequence: MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNHSIRSNVLIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETGGTKQDQEVSTEEAPFPSLFSEEREDLDKIDEMEEIRVNGKDKINKDDEFHVRTYYNYKTVSENLDGNKENSNLEFFKIKKKEDRFLWFEKPFVTLVFDYKRWNRPNRYIKNDKIENTVRNEMSQYFFYTCQSDGKERISFTYPPNLSTFFEMIQKKIPSFTREKRPSDQVSTYWSLINEEKKENLKKEFLNRIDALDKEWSGENILEKTTRFCHNETKKEYLPKIYDPFLHGVSRGRIKKLPQFQIITESNRKKNIGGSWINKIHGILLKINYHKFEQTIEKLNRESLSIEKKLSFFSEPQEEKIYSEEEIQIFKFLFDVVITDSNDQTLIKNFMDFHEITKKVPRWSYKLISELEDLEGENEENVTMEPGIRSRKAKRVVVFTDKEPHNEIYTNLKDNQNSDQNDEMALIRYSQQSDFRREIIKGSMRSQRRKTVIWEFFQAKVHSPLFFDRIDKLFYFSFDIWGLKKKILSNLMCKKKKKKKMDKKDEEQSKIEEKRQIEIAETWDSFLFAQIIRGSLLVTQSILRKYIILPLLIIIKNSVRMLLFQFPEWSEDLKDWKREMHVKCTYNGVQLSETEFPKNWLTDGIQIKILFPFYLKPWHKQSSQKARLKKKRDKGEKKDFCFLTVWGMETELPFGSAQKKPSFFEPISKELKKRINKFKTKSFLVLRIFKERATIFIKVTKEIKNRILKNFLFIKGKIKDLSKRNLIPLFGPREIYELNETKKDSIMSNQMIHELSVQKKSMEWTNSSLSENKIQNVIDRIKTIRNQIKEISKEKQNLTNSCNKLRYDSKIIEPSKKIWQTFKRKNTRLIRKSIFFIKFCIEQLSIAIFLGIINIPRITTQLFFESTKTILDKYIYKAEENGEKKKKKKNTIYFISTIKNLISNKKKISYDLCSLSQAYVFYKLSQIQVSNFSKLKAVLEYNICITSLFVKNQIKDFFQEQGIFHYDLKDKTFFNSEVNQWKNWLRSNYQYNLPQIAWARLVTKKWKKKINQDSLVLNPSLTKEDSYEKKKFDNYKKQSVFEADSLLNPKHNLKKNSIYNLFCYKSIHSTEKTFDTSIGIALDNCLVSCFLEKYNIRGIGEIRHRKYLDWRILNFWFTKKVNIEPWVDTKSKKKYINTKVQNYQRIDKITKTGLANQKSLFFDWMGMNEEILNRRITNFEFFFFPEFFLFSSTYKMKPWVIPIKLLLLNFNENINVNKKITRKKKGFIPSNEKKSLRFYNLNKEEKESASQVELESDKENKKNPESALLKQEKNIEENYAESTIKKRKNKKQYKSNTEAELDLFLTRHSRFQLRWNCFFNQKILNNVKVYCLLVRLKNPNEIAISSIERGEMSLDILMIEKNFTFAKLMKKGILIIEPVRLSVQNDGQLIIYRTIGISLVHKNKHKISQRYKKKSYSDKQKIEKSITKYQNKTVNRKKNNYDFFVPENILSPKRRREFRILICFNLKKKNARDRNSRFDKNIQNLTTVLDKKKDLVKNKNNLIKFKSFLWPNFRLEDLACMNRYWFNTTNGNHFSMIRIHMYTRFPLH
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: Y2909_PSEPG
Sequence: MIISTTSQLEGRPIAEYLGVVSSESVQGINFVRDFFTRFRDFFGGRSQTLESALREAREQATEELMARARQLQADAIVGVDFEISMPSVQGGMVVVFATGTAVRLK
What are the official names of this protein?
UPF0145 protein PputGB1_2909.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RL2_MYCPA
Sequence: MAIRKYKPTSPGRRGASVSDFSEVTRSTPEKSLVRPLHGHGGRNAHGRITTRHKGGGHKRAYRVIDFRRNDKDGVNAKVAHIEYDPNRTANIALLHFLDGEKRYIIAPQGLSQGDVVESGPNADIKPGNNLPLRNIPAGTVIHAVELRPGGGAKLALSAGSSIQLLGKEGSYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRHPNKASNKLIVRRRRTGKKHGR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PURA_SYNP6
Sequence: MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTVVVGEQTLKLHLIPSGILYPDTQCIIGSGTVIDPKVLLGEVEMLEQLGISTDHLLISQTAHVTMPYHRLIDQASEQQRGSHKIGTTGRGIGPTYADKSERTGIRILDLMDPEGLREQLTWTIAQKNVILDKLYGLPPLDAESVIEEYSGYAERLRPHVVDSSLTIDEAWRKRKNILFEGAQGTLLDLDHGTYPYVTSSNPVAGGACIGAGVGPTIIDRVIGVAKAYTTRVGEGPFPTELHGDIGELLCQRGAEFGTTTGRRRRCGWFDAVIGRYAVRINGIDCLAITKLDVLDDLDEIQVCVAYDIDGERCDHFPSSARSFANCQPIYKTVPGWKQSTSHCRNLEDLPKAALDYLKFLAELMEVPIAIVSLGASRDQTIIVEDPIHGPKRALLHTNGDSSAS
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMLN_HUMAN
Sequence: MVTTLGPKMAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCIWH
What is the function of this protein?
Metalloprotease.
What are the official names of this protein?
Leishmanolysin-like peptidase, Invadolysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M8 family.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.
Protein: TDH_BURO1
Sequence: MKALAKLERGPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLHMTEGFDVGLEMSGVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAADDYEQGFAAMLSGESGKVILDWTA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: HEM1_MYCA9
Sequence: MSVLLFGASHRSAPVPVLEKLAIGEADQPKIIEHILQSPLVTEVMVLSTCNRVEVYAVVEAFHGGLTVIGEAIARHAGMGMNELTKYAYVRYSEAAVEHLFAVASGLDSMVVGEQQVLGQVRNAYATAESHQAVGRVLHELSQSALRVGKRVHSETGIDAAGASVVSVALNLADNKLDGLPGRTAAVVGAGSMGSLATAQLIRAGIDNLWVVNRSAERARRLAATAREAGVNAQAITLDNLDQALAQADVVVSCTGAVRPVISLADVHHALEGGRQLVFCDLGMPRDVDPTVAGLPGVVVVDMERIQREPTARAAANDAGAARQIVNDEVARYLTGERMAEVTPTVTALRQRAAEVVEAELLRLDGRLPGLAGAERDEVAKTVRRVVDKLLHAPTVRVKQLASAPGGDSYAEALRELFELDPHTVEAVATAGELPLATKELHE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: HSCB_SALAR
Sequence: MDYFTLFGLPASYHIDTQALSLRFQDLQRQYHPDKFANGTQAQHLAAVQQSATINQAWQTLRHPLTRAEYLLSLHGFDLASEQHTVRDTAFLMEQLTLREELDDIEQTKDDARLESFIKRVQKMFDTRLQQMVTQLDNAAWGEAADTVRKLRFLDKLRSSADQLEEKLLDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: TTCA_XANOM
Sequence: MTAVLPLPHPLADPAPRDPRQRLQREQLRLGKRLQRQVGQAIADFGMISPGDKIMVCLSGGKDSYTMLDMLLQLQRKAPVPFTLVAVNLDQKQPDFPAHVLPAYLDALGVPFDIVEQDTYSVVSRVVPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFHHARLAAMAPKLRSDDGAHVVIRPLAYVREAHIAAYAQARQFPIIPCNLCGSQENLQRQQVGKMLQHWDHEQPGRVEQIARALGDVRPEQLADRTLFDFLALGRSGDAPPDLAPDPGAWLTASDATHDSD
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_SHEFN
Sequence: MAKVPSRSPRKRVRKQVADGMAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAGIAAQDYGVKNLEVFVKGPGPGRESAIRALNAVGYKITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: OPSR_BOVIN
Sequence: MAHAWGPQRLAGGQPQANFEESTQGSIFTYTNSNSTRDPFEGPNYHIAPRWVYHLTSAWMVFVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAIADLAETIIASTISVVNQMYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAITGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCFIPLSVIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCLCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDSSELSSVSKTEASSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Long-wave-sensitive opsin 1, Red cone photoreceptor pigment, Red-sensitive opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYN_LEPIC
Sequence: MSETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEVFQTVKHLRQETSVTVIGNLVKNEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQRHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPILTGSVGESAGTLFSTEYFDLGNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENLKLQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIVWGDDINSEREQILTVEFGGPVFIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEIIGGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPHSGFGLGSERLIAWICGLAHVRECIPFPRMMERLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUN4_TABYA
Sequence: MKVLSLIFVIFSVLVLFASAKDPVCDQPKAVGRCFAAFPKFYFNSSSAQGEAFFYGGCGGNENNFNTLEECNAKCA
What is the function of this protein?
Potent anticoagulant protein that inhibits the hydrolytic activities of all serine proteases tested (trypsin, thrombin, elastase, and chymotrypsin), with the highest efficacy on thrombin.
What are the official names of this protein?
Tabkunin 4, Serine protease inhibitor 4.
What are the subcellular locations of this protein?
Secreted.
Protein: KYNU_CRYNJ
Sequence: MSNDLPTKKDLVKWDQEDALNWTRGEYEIPNSKACGGEADGKAIYFCGNSLGLLNKKARQHIMEELDVWSTSSVTGHFNHPYQRPWKHVDEPLTPHLAKLVGAREEEVAHTSTLTSNMHNLFTSFYQPTEKRWKIVIEKGSFPSDWYAVHSHPRLHDKVLRPEQIDNAIIALVPREGEDTLRTEDILKVLDDNKDSIAIVWLPLVQYYTGQLFDISSISPKVHEIGALLGLDMAHGIGNVECKLNEWNVDFAVWCTYKYLNAGPAAIGGFYIRSGLEDGGRRLAGWWGNDARTRFHMSPNFQPTPGAKGYQHSCTPVFSSIPLLATLQLIEAVGFSNMVEKARRLTGTLEALLKASRYHVHPADPKGKIGFKIITPAAPYRGTQLSLVILPEEEHVMPKVFDRMLRKGLVGDERKPSVIRLSPVVLYNTFEEVGRAVEIVEEALEEEEEERKR
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, Biosynthesis of nicotinic acid protein 5, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_POLSJ
Sequence: MARITVEDCLEKIPNRFQLVLAATYRARMLSQGHAAKIESKNKPGVTALREIAEGKIGLEMLKKVPS
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: VL2_HPV33
Sequence: MRHKRSTRRKRASATQLYQTCKATGTCPPDVIPKVEGSTIADQILKYGSLGVFFGGLGIGTGSGSGGRTGYVPIGTDPPTAAIPLQPIRPPVTVDTVGPLDSSIVSLIEETSFIEAGAPAPSIPTPSGFDVTTSADTTPAIINVSSVGESSIQTISTHLNPTFTEPSVLHPPAPAEASGHFIFSSPTVSTQSYENIPMDTFVVSTDSSNVTSSTPIPGSRPVARLGLYSRNTQQVKVVDPAFLTSPHKLITYDNPAFESFDPEDTLQFQHSDISPAPDPDFLDIIALHRPAITSRRHTVRFSRVGQKATLKTRSGKQIGARIHYYQDLSPIVPLDHTVPNEQYELQPLHDTSTSSYSINDGLYDVYADDVDNVHTPMQHSYSTFATTRTSNVSIPLNTGFDTPVMSGPDIPSPLFPTSSPFVPISPFFPFDTIVVDGADFVLHPSYFILRRRRKRFPYFFTDVRVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: SYW_SALTI
Sequence: MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKATLDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNGLYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEKAGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEAFLQKVMKDGAEKASARAAETLKAVYEAIGFVAKP
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SAT_NAJAT
Sequence: LKCNKLVPLFYKTCPAGKNLCYKMFMVSNKMVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Basic protein that binds to cell membrane and depolarizes cardiomyocytes.  It also possesses lytic activity on many other cells, including red blood cells.  Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes.  It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation.  Inhibits protein kinases C.  It binds to the integrin alpha-V/beta-3 with a moderate affinity (By similarity).  Is cardiotoxic and cytocidal to Yoshida sarcoma cells.
What are the official names of this protein?
Cytotoxin 5, Cardiotoxin A4b, CTX-A4b, Cardiotoxin T, Cardiotoxin analog V, CTX V, Cytotoxin D-1, Membrane toxin D1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.