PharMolix/UniProtQA huggingface dataset:
Protein: SCXJ_TITBA
Sequence: KEGYAMDHEGCKFSCFIRPSGFCDGYCKTHLKASSGYCAWPACYCYGVPSNIKVWDYATNKC
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).  This toxin is active against both mammals and insects.
What are the official names of this protein?
Toxin Tb2-II, P-Mice-Ins-beta* NaTx5.4.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_ACTP7
Sequence: MATGKIVQIIGAVIDVEFPQDAVPKVYDALKVESGLTLEVQQQLGGGLVRCIALGTSDGLKRGLKVENTGNPIQVPVGTKTLGRIMNVLGEPIDEKGPIGEEARWDIHRAAPSYEEQSNSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDSTVVLSRNIASLGIYPAVDPLDSTSRQLDPLVVGEEHYNVARGVQGTLQRYKELKDIIAILGMDELSEDDKLVVARARKIERFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGILEGEFDHIPEQAFYMAGSIDEVVERASKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACT2_ARTSX
Sequence: MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSIYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLIDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
What is the function of this protein?
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin, clone 211.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VAPC2_MYCBO
Sequence: MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.
What are the official names of this protein?
VapC ribonuclease Mb0640, RNase Mb0640, Toxin Mb0640.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: NFUA_BUCCC
Sequence: MIKISKKAKKYIIKLLSKQELGTNIRIFVDSPGTMYAECGMAYCDMNDIDKKNDHKFSFDFFDVYIHKLMLPFLKDSIIDLVKNDLGTKITLKAPYAKILNKSKNFSQLQNSIKNFLTTQINPKLLLHGGSVALYDITDSGVVFLKFSGGCNGCSMIDITLKKGIEKKLIKNFPEISSVEDVTHHISGKHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: GYRB_MYXXA
Sequence: MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAVDESLAGHCTDIEVVIHVDGSLSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQGVPDTPPREVGTTDKRGTHIAFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEYLNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAALTRTLNSYAEKGSLWKDLKETPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGLVEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKARETVRRKGVLDGGGLPGKLADCQIRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKLLREMLTSAEIVTLITALGNGIGAEDYDPEKARYHRIFLMTDADVDGSHIRTLLLTSSSGRCRSSCRRAISTSRSRRSYKVTRNKKDQYVKDEHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITYEERLEKQAKRRDARVVDALVQGARLSAETLTGRGCPGGGGEGRLMTPSSAACRTCWAACATSWCRTPSTTPRSWCSTPTRMEPCGRRCSTTPSCRRRSTWSCRLCAEHLRGAGQGAVQGPRGRGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVEDAVESDEIFSLLMGEAVEPRREFIERNALDVQNLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_SALA4
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPVDNDGFSAVEAIAPGVIDRQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELAKIGSFEAALLAYVDRDHAPLMQEINQSGGYNDEIEGKLKGILDSFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WDR70_BOVIN
Sequence: MERPGPSDGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITIKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI
What are the official names of this protein?
WD repeat-containing protein 70.
What is the protein family that this protein belongs to?
Belongs to the WD repeat GAD-1 family.
Protein: CLPP_NYMAL
Sequence: MPIGVPKVPFRSPGEEDAVWVDIYNRLHRERLLFLGQGVDSEISNQLVGLMVYLSMEDNTRDLYLFINSPGGWVIPGIAIYDAMQIVPPDVHTICMGLAASMGSFILVGGEFTKRLAFPHARVMIHQPASSFYEAQAGEFILEAEELLKLREILTRVYVQRTGKPLWVVSEDMERDVFMSATEAQAHGIVDLVAVENSADFV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: HISX_STAES
Sequence: MLSAQQFLKEFNNVESLNESLYEIVSHICEEVKLQGDKALKNYNLQFDQVETEKLELEQSQLKNAYDMLDNETRDALEQSYQRIKVYQENIKVKQESSQQTECYERYHPIERVGIYVPGGKASYPSTVLMTATLAQVAGVNEITVVTPPQNNGICQEVLAACYITGVHHVYQVGGAQSIAALTYGTETIKKVDKIVGPGNQYVAYAKKFVFGQVGIDQIAGPTEIALIIDESADLDAIAYDVFAQAEHDEMACTYVISENEKVLNQLNTIIQEKLQYVERQDIISQSIANHHYLILAQDTEEACLIMNTIAPEHASIQTRAPEMYIDKVKYVGALFLGHFSPEVIGDYMAGPSHVLPTNQTARFTNGLSVNDFMTRHSVIHLSQKTFNEVAESAEHIAHIESLFNHEKSIHVRR
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: COHA1_CHICK
Sequence: MDSVTKKTRQDGSEVTERQGGSSSGLKTSSHTGGSGVEKRSYTHSSGYVTSSGSGRLNSSSSGYRQTQSPSSTLTKSPGSTFERKTYVNRHATYEGSSSANSSPEFPRKEFASASTRGRSQSRESEIRVRLQSASPSGRWTELDDVKRLLKGSRSASCSPTRSSSSTLPIPKKAVVETKMVTESSQSVSGTYDTTILNTTLPPYTWSSTLPAGSSLGGYHNSMGQSSSLINAMSHSTGSVFGVPNNLAPSSHALNTGLSTSSTVFGVQNNLSPSSSALNASAASAAYGMKNTSQTNTMNSTGVSASAGGTILSSQGDDFLHKDCKFLLLEKENAPAKKEMELLVMTKDSGKVFSASSTGLNGGSFAEDTLKKEKQGLSSYAADTGLKSDANGGLKSAPTRDKATYAEIQNGGAGGAIGSAPSWCPCGSCCSWWKWLLGLLLAWLLLLGLLFGLIALAEEVRKLKSRVDNLEKINHSFLTVNQGNPYLEKDVSKVDFLHGVAPSSTFPFENEESVWLMVKSRLNKEIERGYFRGERGEPGMKGDMGLQGPKGDRGLPGVPGIPGPVGHQGPEGPKGQKGSMGDPGMEGPMGQRGREGLPGPRGEPGPPGFGEKGDRGAAGPPGPPGPPGSAGLKGPMGSPGPQGPPGPPGLQGFRGEAGLPGAKGEKGATGPPGPKGDQGEKGARGMTGEQGSRGIPGPPGEPGAKGPAGQAGRDGQPGERGEPGLMGMPGARGPPGPSGDTGEPGLTGPQGPPGLPGNPGRPGAKGEPGAPGKVISAEGSSTIALPGPPGPPGPIGPTGPPGVPGPVGPAGLPGQQGPRGEKGSAGEVVIETIKTEVSSLASQMLSDLQGRAGPPGPPGPPGESVQGLPGPRGPPGLPGPSGPPGRPGSSVSTSETFVSGPPGPPGPPGPKGDQGEPGPRGFTGEPGEPGLPGFSSHGGTVTMQGPPGPPGPPGPKGDAGVPGAPGIPGTSRGGSRQIQGPPGPPGPPGPPGPGGSSSQEIQQYVADYLKSDNVRHYLTGVQGPPGPPGPPGILTTADGKNFDFAELATRVMSYVTSSSDHYQSFASSVSTTSVLYQELLNMLQREEIRQYLVGPRGPPGPPGPGVDGMSLSLDYDELTRRFISYLTSSGMSIGLPGPPGPPGTPGISYSELTAYLRNSEFSGLVGPPGPAGPPGPPGIPGSSGISLEDISAYLQSVGYSSISGIQGPPGPPGPPGPPGFSGTGLLSYADITHSDEFRSELIQYLKSDEVRSYISGPPGPPGPRGPPGPKGDSGLVAGSMSSLYHDSLASERLHGGSIGAEGSHGGSLGASSSYGSSMSSSMSSYSASMGSDGSYGASVGSDGSFDGLLTAEESHRRSAGPGRSYSSSFTGSLDYNELARHVSENLQSRGILQDLMSYTGQGPPGPPGPPGPPGISRVFAAYGNVTEDLMDFFRTHGTVRGPPGEKGERGYPGPKGDPGPMGPPGRHGQRGPKGEKGEKGEQMYSGRRRRRSVGV
What is the function of this protein?
The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.
What are the official names of this protein?
Collagen alpha-1(XVII) chain, 180 kDa bullous pemphigoid antigen 2, Bullous pemphigoid antigen 2.
What are the subcellular locations of this protein?
Cell junction, hemidesmosome. Membrane; Single- pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome. SUBCELLULAR LOCATION: [120 kDa linear IgA disease antigen homolog]: Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: ILVC_RUEPO
Sequence: MRVYYDRDCDINLIKDKKVAILGYGSQGHAHALNLRDSGAKNLVVALREGSASAKKAEGEGLTVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNIRPGAAIAFAHGLNVHFGLIEPKEGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHTDATGKALEIGLSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMDYSISNTAEYGQYVTGPRILPYEQTKASMKAVLTDIQQGKFVRDFMLENAVGQPTIKASRRANDEHQIEQVGQKLRDMMPWISAGKMVDKSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: BGBP_TENMO
Sequence: MKVLVVFIFCLVRSTFGQFEVPDALVEVFRPRGLRVSIPDQEGIKLFAFHGKINEEMNGREGGTFSRDILKAKNGRWTFYDANARLKEGDILYYWTYVDYFDGKNKLGYPNDDQKFVVKQLLDKDGAAPSVTPPTVTKAPPQEHTTLESGCKASVTTKVNERVCAGEQIFHEDFTTFETNIWRPEVKFADKPDYEFVFYRAGPPNLQVKHHRLTIRPVPSDAVFGEGFVSRREKVNLAPACTGVHGSIECVQTPGAFLILPPVTSAQISTKGKWSFKYGKVEIRAKLPKGDWIYPELYLNPVNEEYGPGYASGQIRIAFSGGNEDLCRDLRGGCILGSRPAARNYAVKNIVKNSGSWSDDFHKFIVIWKPDQITMMVDDQVYGNIYPPEGGFVSEAYNLDLVNVERWRGGTSFAPFDKEMYLVLGVGVGGHCFEDRSDATKPWTNNDPKSQKKFYQAAAQWGATWSNASRLEVDYVKVSAL
What is the function of this protein?
Involved in the recognition of invading microorganisms.  Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade.
What are the official names of this protein?
Beta-1,3-glucan-binding protein, BGBP, Beta-1,3-glucan recognition protein, BetaGRP.
What is the protein family that this protein belongs to?
Belongs to the insect beta-1,3-glucan binding protein family.
Protein: Y4632_PSEU2
Sequence: MSYVIDRRLNGKNKSTVNRQRFLRRYRDHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPVLHHGRGGKQTVVHPGNKEFTTGEHIARPQGGGGGKGPGKAGNSGEGMDEFSFQITQEEFLEFMFEDLELPNLVKRNLTGTDTFKTVRAGISNEGNPSRINIIRTLRSAHARRIALSGSSRAKLREATAELERMKREEPDNFGDIQELEVEIDRLKARIRRVPYLDTFDLKYNLLVKQPNPSSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYDKIDVVFIRHHTSAREVDEEEFFYSRETGGTIVSSALKLMQEIMAARYPSSDWNIYAAQASDGDNWNDDSPICREILTKQIMPFVQYYTYVEITPREHQALWYEYERIGEDFADTFAQQQLVSAGDIYPVFRELFQRRLVS
What are the official names of this protein?
UPF0229 protein Psyr_4632.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: DUS3_SCHPO
Sequence: MAELETGAVPIREEFLVKQDGNKKRKRKERGQNKRREKIHVKENNALCPAISIGNECPYKENCKFPHDVEAYLATKAPDIGDKCPIFERYGVCPAGFKCRWLAGHVVINADGKYELIKKPDGQFTLFTVNTVGKEVQRKLRTKQLDLSKAESIISAVLGEEKPDPSSKVSNIPEENRDATSAISEGKETESVSLEETGVLKNQTVSVNVDLKEISSQARSNIALPTLRPQEKNLIDWRDRKILAPLTTVGNPPFRRLCGSLGADTFYSEMAMCYPLMQGHQPEWALVRGLNYEREMMRGGRRGILGVQLATGKLWQATKTAQVIAEQCDGVDFLDLNCGCPIDLVFRQGAGSSLLENPGRLLRNLQGMDAVSGQIPVTVKLRMGNKDDHPVVKNLIGRIFNETNTSAATLHGRSRQQRYSKNANWDYIGEIASKVKSMNERIDELPEDSLRTQPLSLIGNGDCYSWQDWYDGVNKGVDTVMIARGALVKPWIFEEIEARQFIDKSSTQRLEMLEQYCNNGLEYWGSDSQGVNTTRRFFLEFMSFFHRYTPIALYEVQRPRLNDRPPLYTARDEMETLLASNKVTDWVKLSEFFLGPTPERFTFTPKHKSNSVEEAEG
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs and mRNAs (PubMed:34798057).  Modifies the uridine in position 47 (U47) in the D-loop of tRNAs (PubMed:34798057).  Also able to mediate formation of dihydrouridine outside of the D-loop of tRNAs (PubMed:34798057).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (PubMed:34798057).  Dus3-mediated dihydrouridylation of the mRNA encoding alpha-tubulin nda2 is required for meiotic chromosome segregation (PubMed:34798057).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase dus3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SLYX_PECCP
Sequence: MSPSALEERLEQLESRQAFQEVTIEELNQTVIQHEREISRLREHVRLLTDRVRNQQTSLVAPQSEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: SIAS_HUMAN
Sequence: MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS
What is the function of this protein?
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:10749855, PubMed:27213289).  Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:10749855).
What are the official names of this protein?
Sialic acid synthase, N-acetylneuraminate synthase, N-acetylneuraminate-9-phosphate synthase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid synthase.
Protein: RF1_SHIF8
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2C2_LACSA
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITSLLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATIGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTENIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: EFTU_RAT
Sequence: MAAATLLRATPRFSGLCASPTPFLQGRLRPLKAPASPFLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLAKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEQRDPELGVKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRVILPPGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTDVPAMTEEDKNIKWS
What is the function of this protein?
Plays a role in the regulation of autophagy and innate immunity.  Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway.  In turn, inhibits RLR-mediated type I interferon while promoting autophagy.  Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MIAB_CUPMC
Sequence: MKKVFVKTYGCQMNEYDSDKMVDVLNATQGMEPTDNVEDADVILFNTCSIREKAQEKVFSELGRMKALKAAKPDLVIGVGGCVASQEGASIVSRAPYVDVVFGPQTLHRLPDLINRRQQTGLSQVDISFPEIEKFDHLPPARVDGPSAFVSIMEGCSKYCSYCVVPYTRGEEVSRPFEDVLAEVAGLAEQGVREVTLLGQNVNAYRGAMGGTSEIADFALLIEYVADIPGIERIRYTTSHPKEFTSRLIELYGRCDKLVNHLHLPVQHASDRVLAGMKRGYSVLEYKSIIRRLRALRPDMSMSSDFIVGFPGETDADFDKLMAMVHEIGYDTSFSFIFSPRPGTPAANLHDDTPHEVKLRRLQLLQATIEENVQRISQSMVGTVQRILVEGPARKDPTELHGRTENNRVVNFALPGVPQAQRDRMIGQMVDVNVTQAFPHSLRGEFVVRQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1813_PROMT
Sequence: MPSSYSFDVVSEFDQQELVNAIDQLRREVDQRYDLKDSKTKIDIKEDELSIVSLSDMTIESVKDILLQKATKRNLSLKIFDFQKIETIGGNMVMQIVKLKKGLSQEISKKLSKLVRDNMKKVTASIQGDSLRITGKNKDDLQAAINLIKKQEEEFDIALQFQNYR
What are the official names of this protein?
UPF0234 protein PMN2A_1813.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: NU3M_PARLI
Sequence: MMTTTIFLFSITSAVAIIFALAAHILPTRNNDGEKNSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFPLPAASFLTHPTTLILISLAFMAILDAGLVFEWINPPLEWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: DER_LACPL
Sequence: MAKPVVAIVGRPNVGKSTIFNRIAGDRISIVEDTPGVTRDRIYANSEWLGQEFSLIDTGGIDIEDAPFIKQITQQAEIAIDEADVIIYLVSIKEGVTDADEHVAQILYRSNKPVVLGVNKVDNPELRSEVYDFYSLGFGDPYPISGAHGLGLGDLLDAVIKNFPEKSGEDEPGTIRFSLIGRPNVGKSSIVNALLGEDRVIVSDVAGTTRDAIDTKFTDQDGDRFVMVDTAGIRKKGKVYENTERYSVMRALKAIDNSDVALFVINGEEGIREQDKRVAGYAHEAGKGIIIVVNKWDLVKKDNHTMQEFEAYIRDQFVYLSYAPIIFVSAKTNQRLEQLPALIKKVNTNHMRRIQSSVLNDVIMDAIAMNPTPSDNGKRLRVYYATQVAIQPPTFVVFVNDPDMMHFSYERFLENQIRNAFDFSGTPIHMIERRRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: YM58C_YEAST
Sequence: MKMNYHLSTSSYTTSMLSCTVLDDDIRYEKLSWKLDEAEMQGLIM
What are the official names of this protein?
Uncharacterized protein YMR158C-A.
Protein: NPB15_HUMAN
Sequence: MRLRFWLLIWLLLGFISHQPTPVINSLAVYRHRETDFGVGVRDHPGQHGKTPSPQKLDNLIIIIIGFLRRDTFTILFCTSYLCVSFLKTIFWSRNGHDGSTDVQQRAWRSNRSRQKGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINRHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAAEHRHSSGLPCWPYLTAEALKNRMGRQPPPPTQQHSITDNSLSLKTPPECLLHPLPPSVDDNIKECPLAPLPPSVDDNLKEYLLVPLPPSPLPPSVDDNLKDCLFVPLPPSPLPPSVDDNLKTPPLATQEAEAEKPPKPKRWRVDEVEQSPKPKRRRADEVEQSPKPKRQREAEAQQLPKPKRRRLSKLRTRHCTQAWAIRINPWVEKKKKIKKQNKTHAPKTN
What are the official names of this protein?
Nuclear pore complex-interacting protein family member B15, Nuclear pore complex-interacting protein-like 2.
What is the protein family that this protein belongs to?
Belongs to the NPIP family.
What are the subcellular locations of this protein?
Secreted.