PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_YERPE
Sequence: MANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQPLMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLEFSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSGMMADWANDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL29_MYCSK
Sequence: MAVGVSPGELRELSDDELIERLRESKEELFNLRFQMATGQLSNNRRLRVVRQEIARVYTVLRERELGLASGPAGEES
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: TATA_SHESW
Sequence: MGGISIWQLLIIALIVVLLFGTKKLRSLGGDLGGAVKGFKNAMSSEEDKKALEDTEAAKTAQTTQQATEKKPESNKEQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AXIN2_HUMAN
Sequence: MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
What is the function of this protein?
Inhibitor of the Wnt signaling pathway.  Down-regulates beta-catenin.  Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
What are the official names of this protein?
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTHFS_HUMAN
Sequence: MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA
What is the function of this protein?
Contributes to tetrahydrofolate metabolism.  Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.  Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
What are the official names of this protein?
5-formyltetrahydrofolate cyclo-ligase, 5,10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase.
What is the protein family that this protein belongs to?
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FXYD7_MOUSE
Sequence: MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIILSKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV
What are the official names of this protein?
FXYD domain-containing ion transport regulator 7.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLYA_METTH
Sequence: MVSNQDYTEKIRQLMKDHNSWMESSINLIASENITSSRVKEALLSDLSHRYAEGLPGERLYEGCRYIDEIEELTIELSKRLFRAEHANVQPTSGVVANLACFFATAEVGDPIMAMEVPYGGHISHARVSAAGVRGFQIYTHPFDFENMNIDADAMKKKILEVKPRIILFGGSLFLFPHPVEEALEAAEEVGARIMYDGAHVLGLIAGGYFQDPLREGADMLVGSTHKTFPGPQGGIILCREELAADIDEAVFPGLVSNHHLHHVAGLGIATAEMLEFGAEYAAQTINNARKLAENLHELGFNVLCEHLDFTESHQVVMDVSDIGRAAEISKRLEANNIILNKNLLPWDDVNRSDDPSGIRIGTQEITRRGMKESEMSEVAEYIKRVVMDGKDVRDEVAEFMSSYTRVHYAFEDSEAYKYMEIQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier.  Cannot use tetrahydrofolate (THF or H4PteGlu) instead of H4MPT as the pteridine substrate.  Also probably exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_SALCH
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGQVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHIAMVGDLKYGRTVHSLTQALAKFSGNRFYFIAPDALAMPQYILDMLDEKGMAWSLHGSIEEVMADVDILYMTRVQKERLDPSEYANVKAQFVLRASDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSELSL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DAPD_ECO8A
Sequence: MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPPB_SHIFL
Sequence: MLKFILRRCLEAIPTLFILITISFFMMRLAPGSPFTGERTLPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPSFKYKDYSVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGLAMTGVVIPSFVVAPLLVMIFAIILHWLPGGGWNGGALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMGPAFVGIITGSMVIETIYGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKIRY
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Oligopeptide transport system permease protein OppB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PXPA_BACAC
Sequence: MTTIDLNCNLGESFGAYKMGNDDEILPFVSSINVACGFHAGDPSVMRQTVEKAMQHNVAIGAHPGFPDLIGFGRRNMNVSANEVYDYVLYQIDALDAFVKAAGGKMQHVKPHGALYNMAATNPEIADAIAKAIYHMNSSLSLYGLANSEAFIQAAEKYNITLVQEAFADRTYKEDGTLTSRTEENALIKNEDEAIKQVLQMVKEGYVNSVNGEKVAVQAQTICLHGDGEKAVQFARKIYRTFEHNKISICAPK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: SSRP_CLOBJ
Sequence: MSKKKGSNTLAENRKARHDYFIEETYEAGIELVGTEVKSIRQGKANLKDSYAEIRNGEVFVRNMHISPYEQGNIYNKDPLRDRKLLLHKSEIYKLVGFTTQQGYTLIPLSLYLKHGRVKVSLAVAKGKKNYDKRDAMLEKAAKREMDRQIKERSRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LDH1_LACLA
Sequence: MADKQRKKVILVGDGAVGSSYAFALVNQGIAQELGIVDLFKEKTQGDAEDLSHALAFTSPKKIYSADYSDASDADLVVLTSGAPQKPGETRLDLVEKNLRITKDVVTKIVASGFKGIFLVAANPVDILTYATWKFSGFPKNRVVGSGTSLDTARFRQALAEKVDVDARSIHAYIMGEHGDSEFAVWSHANVAGVKLEQWFQENDYLNEAEIVELFESVRDAAYSIIAKKGATFYGVAVALARITKAILDDEHAVLPVSVFQDGQYGVSDCYLGQPAVVGAEGVVNPIHIPLNDAEMQKMEASGAQLKAIIDEAFAKEEFASAVKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_BUCBP
Sequence: MQIILLEKLDNLGNKGDILFVKSGYARNFLIPYGKAIFATKDNIKFEINKKEELERELIKKISIAKTKCEKIKNIKSIVIPAQVGIEGKLFGSVGSRDIAKKLSELSNIKIKKHEIYFLNGALKHVGQHKVIFKPHHSVSITVEINIVSQDKDK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TRDN_CANLF
Sequence: MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAVVMFDLVDYKNFSASSLSKIGSDPLKLVHDAVEETTDWVYGFFSLLSDIISSDGDEDDDDGDEDTDKGEIEEPPLKQKEIHKEKAEKEEKPERKILAKVAHREKEKVKEKEKSEKKATHKEKIEKKEKPETKTMAKEERKAKTEEKIKKEVKGGKQEKVKPTAAKVKEVQKTPPKAKEKEGKETAAVAKHEQKDQYAFCRYMIDMFVHGDLRPGQSPALPPPLPTVQASRPTPASPTLEGKEEEEKKKAEKKVTSETKKKEKEDVKKKSDKDTAIDVEKKEPGKAPETKQGTIKVVAQAAAKKDEKKEDSKKTKTPVEEHPKGKKQEKKEKYVEPAKSSKKEHSAPSEKQVKAKTERAKEETSAASTKKAVPGKKEEKTTKTVEQEIRKEKSGKTSTASKDKEPEIKKDEKMPKADKEVKPKPPQSQVKKEEKSESQVKKEAKPEQDIAKPEKTVSHGKPEEKVVKQVKATEKAAIEKTVKPKPAKKAEHQEKESPTIKTDKPKPTSKETPEVTESGKKKIEKSEKESKEKAEMKHLKEEKVSTRKESLQSHNVTKAEKPARVSREDLEDVSASKKAKEEAEDVSSTKRQKSPISFFQCVYLDGYNGYGFQFPVTPAYRPGESSGQPSSPGQKQQGQ
What is the function of this protein?
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction.  Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact.  Required for normal skeletal muscle strength.  Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
What are the official names of this protein?
Triadin.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: HSE1_CRYNB
Sequence: MFSTATSPYDDLVIKATDENLASEDWALNMDVCDKVSSDGQNGARQAVTALQKRLSHRNPNVQIYALELANSLAQNCGKDLLGELSSRNWTSALDRLINDRATSTPVKKKALSFVKSWAKQIEETGDPNLGLMGELYDQLRAKNHVFDEPEPTPESAEEARRRQEEEELQRVLELSKQDKGGRSLFTYQPSGSAGASSSSAANNNTSPSIPQSQAQPLAQDQAQSQAAPQVTGYAPQPQKIYSPQPLEPEPPRVDLNTATCVRAIYPFTGQEVGELDFERGDVIKVLDRGFKEWWRGACNGKIGIFPVTYVEALPEPTPKELQEKAQEEARVFASLGLVDQLLQTLKGIDPARGDKLDDHPEIEEMYQASVALQGQINTLIKKYSDQKAELEHMNANFIRAMGQYEELRNGPPLVQAQPFGYVPPQPQPLLQQQNSYSYQQYPQQPQQQPQPYAQAPYAQQAQPQLQPEQYAQQTPSPAAQSQASYTAQQQPYPAQVQQDPAAASPPPNQPFYHHGGSTTSVNRIPSAQTAVQPQPHGAPSFPPSSPPTRQVTEPGVAGLGAGDQQAWDQYYQQHGQQAPHSSQHPSQPQSQPQSQPQSQPQSQQGSYYPAHAQAQGYQAAYATVPDGRAYASPPLPGTQQGQGVEGVTAGMDRMSVHAP
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
What are the official names of this protein?
Class E vacuolar protein-sorting machinery protein HSE1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: S15A5_MOUSE
Sequence: MPITDFIINDEKTPLVLHGGPEQWKTVGPYGCFRVGICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIYRPENRCSLLTIARAFVRALKTRCLPYCHFGRDGSSWLDHAMEKQGGHHSELQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKLAREQSPSGKLFSVSSMACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIPGASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLMLLNILGLWRASWRYCNLNHFNAQRIRGNRCEETLLLTEKSLKFYGSTQGASSSIDLWETAL
What is the function of this protein?
Proton oligopeptide cotransporter.
What are the official names of this protein?
Solute carrier family 15 member 5.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MURA_CAMJR
Sequence: MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENLGAKVNFQNNSALLNTNTLNQTIAKYDIVRKMRASILTLGPLLARFGHCEVSLPGGCAIGQRPIDLHLLALEKMGANIQIKQGYVVASGNLKGNEILFDKITVTGSENIIMAAALAKGKTKLLNVAKEPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLEFKEFSVIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVLAKLHQMGFETLIAEDSITLLPAKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTSIIDERLFENRFMHVSELLRMGADIKLNGHIATIVGGKELNAADVMATDLRASSALILAALAAKGTSKVHRIYHLDRGYENLEEKFKGLGVKITRLEE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_HELP2
Sequence: MQHLVLIGFMGSGKSSLAQELGLALKLEVLDTDMIISERVGLSVREIFEELGEDNFRMFEKNLIDELKTLKTPHVISTGGGIVMHDNLKGLGTTFYLKMDFETLIKRLNQKEREKRPLLNDLTQAKELFEKRQALYEKNASFIIDARGGLNNSLKQVLQFIA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTK1_ENCCU
Sequence: MEPAEEGEILAHRRFTATKMEYEKIRIIGEGTFGQVILARKGRARYALKKVSKEKEGLSVTTIREVQVLRAMGHPSIVRLIEVVVEPGGDIYMVFPYFPYDLNRFIRSNKMTCSEIKHIFYQIAQGVCYIHSKGIMHRDLKSANILLDQKLNASIADFGMARYTTKTGAYTPGMVTLWYRAPEILLGSSSYTYAVDIWSLGCILTEMYLGHMIFQGSTEMLQLEMVIHACGSINENSYPGVQDLPGFRNFRLPQSPRRIEGIIRKHDASAVELVSKMLCLDPSKRITVEQVVGSKYFEHEARRDASSAGLQGCSYREDRLSLSKRKNVD
What is the function of this protein?
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit.  Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity).
What are the official names of this protein?
Probable CTD kinase subunit alpha homolog, CTDK-I subunit alpha, CTD kinase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RN128_MOUSE
Sequence: MGPPPGIGVYCRGGCGAARLLAWCFLLALSPHAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVSGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEANSVAVDVVPHVDNPTFEEDETPDQEAAVREIKS
What is the function of this protein?
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation.  Functions as an inhibitor of cytokine gene transcription.  Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production.  Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse.  Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF128, Gene related to anergy in lymphocytes protein, Goliath-related E3 ubiquitin-protein ligase 1, RING finger protein 128, RING-type E3 ubiquitin transferase RNF128.
What are the subcellular locations of this protein?
Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A.
Protein: CYB_RHIWE
Sequence: MTIMRKKHPLLKMINHSFIDLPTPSNISSWWNFGSLLGMCLMIQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYMLLETWNIGIVLLLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYXGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPSGLDSNSDKIPFHPYYTIKDLLGALILLMVLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILATLPLLNSSKQHGLIYRPITQALYWIFVANLLTXTWIGGQPVEXPFTLIGXIASXLXFXIIIIFMPIASTIXNNIPXLH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PHZI_PSECL
Sequence: MHMEEHTLNQMSDELKLMLGRFRHEQFVEKLGWRLPAHPSQAGCEWDQYDTEHARYLLAFNEDRAIVGCARLIPTTFPNLLEGVFGHTCAGAPPKHPAIWEMTRFTTREPQLAMPLFWRSLKTASLAGADAIVGIVNSTMERYYKINGVHYERLGPVTVHQNEKILAIKLSAHREHHRSAVAPSAFMSDTLLRETA
What is the function of this protein?
Required for the synthesis of a yet unknown N-aceyl-homoserine lactone (N-aceyl-HSL), an autoinducer molecule which binds to PhzR and thus regulates phenazine production.
What are the official names of this protein?
Acyl-homoserine-lactone synthase, Autoinducer synthesis protein PhzI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: THIG_MYCUA
Sequence: MVESKLMIADRSFASRLIMGTGGASNLAVLQEALVASGTELTTVAIRRVDAEGGTGLLDLLNRLGITPLPNTAGCRSAAEAVLTAQLAREALATNWVKLEVIADERTLLPDAIELVRAAEQLVDDGFVVLPYTNDDPVLARRLEDTGCAAVMPLGSPIGTGLGITNPHNIEMIVASAGVPVVLDAGIGTASDAALAMELGCDALLLATAVTRAADPAAMAAAMSAAVTAGYLARCAGRIPKRFWAQASSPTLVTTQSPGAESGN
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_PHOPR
Sequence: MSLTSRSLLATMISLALYGPAMANENNKLSEDVNDELALTSDNADEIELVRGVCIAPQDRSTDPNNDPIKVTADHAEALDKTKVTYTGDVVVQQGNRTIAADQAYLRQPENIVVAEGNVYFHDGTIEVDSERLQSDLDTEDSEMDHAVYNLTCEPGRGEARRITKTHAQGTQFYRMKDGTYTTCPAEDNSWRFSATTLEREGDSPFANLYNARFEVLDVPVFYLPYLRVPVGKERLTGFLYPSVSYGSRDGFEFETPFYWNIAPNYDLTLTPKYMSNRGLQLNTDFRYLTEFGQGSLKGEYLASDKAADNNDSRWAFNYSHNGTYKSNWLFDVDYSKTSDFNYFTDIDSSIGNREDNNLLQTAEVSYREQYWDSTLRVRDFQPLTETGQGSQYRLMPQLEFNYYRPNLPYELDFSMASSISSFANDASNKPDATRVHLEPTLTLPFATPWWSLTSEAKLLYTYYNQDLKSYSRDGIEETVSRTIPTARIHSGLYLERDTSIWGQDYTQSLEPQIQYLYVQDKDQSGIYNPVNDDGGGYDSTRLQQDYYGLFSDKTYSSVDYVAPANQFTVGASTRYFDGNFKERFTLSLGQIFYIDKPTVDDEVESYSATALETEFNYADWLFFKSSMQYDASDKEVQIANGAIEYRENGVYIQPNYRYVSSSYLDKYVTNPNSVNDDGDQDGISQLGLSTGFPLNGGLSVRADYFHDLNVNKMVEGQVGLTYRSACWLIGLTYNKYASSSLGSSNTEYDNNVSLTFSLLGLQGAKPFGASSDTSNAMSYGNSFSLNN
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.