PharMolix/UniProtQA huggingface dataset:
Protein: PURA_THEON
Sequence: MPSYIVVGGQWGDEGKGSLIAYLALKDEPQIIARGGVGTNAGHSVFINGRKYAVRQLPTGFMQTKARLLVGAGVLVDPGVFFHELEHLKEFNVAERVGIDYRCAIIEPRHKERDRASSYLHDKIGTTGSGCGPANADRVMRMAKQAKDIKELEPYLTDVAQEINDALDEGKLVLIEGTQGFGLSLYYGTYPYVTSKDTTASAIASDVGIGPTRVDDVIVVFKSFPTRVGEGPFPTEMSAEEAERLGLVEYGTVTGRRRRVGWFDFEFARYSARLNGATMLAITMLDKYDKGAFGVTDYDKLPRKAKEFIEEIEERVGIPVGIIKTGPELEHVIDRRDTL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_CLOBK
Sequence: MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRAKYGFDCETCSVITSIDEQSVDIAIGVDEALESKKGEMDKLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEVRKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEVYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSISVDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_STAEQ
Sequence: MEFNTYIGRAGTGKSTAMLNQIKNKMKQDPLGDPIVLIAPTQSTFQLEQAFVNDSELHGSLRTEVLHFERLSHRVFQEVGGLTEQRLSKAALEMMIFHIVQQHESDLKLYGSQAQYYGLSEKLAEQIQDFKKYNVTPEHLNQLIENHSIQTRTKHKLEDISLIYKQLESRMNGEFITTEDSLQQFIEILSQSQWIKKAEVFIDGFHNFSTLEYRIIEALVQHAKQVTVLLTTDGSHHPFSLFRKPSEVLSHLEDIANRLNINLNKTYFNTFYRYNNDDLKNLENGFDALQFTPKHHQNHVKIFESSSMREEINEVARRILKDVREADYKFRDIAILYRDESYAYLFESILPSYDIPFNIDTKKSMTHHPIMEMLRSLLEVIRSNWHINAMLRLFKTNVLTSQFKRSSYLIDLLENFVLERGIYGKRWLDEDIFSIDQFSRMGRKSHQLTEGHQALYKEVIKLKKNVINKVLYFEQAMNEAHTVKDYATSFYESLEYFELPSQLMTQRDELELAGLTEKAEEIDQVWNGLIQILDDLVTVFDDQEMTLQQFLDVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKKHIYMVGMNDGILPQTVSSSSLITDEEKKYVEDNAHVELSPTSDILQMDEAFVCYIAMTRSQQSVTFSYSLMGNSGDEKEISPFLTQIKELFYDLEITNLQDLHKAQPLLMMQHSHQTKIQLFEYLRGWLDHEDIDYRWLDAYLAIRDDDQLNQGLDYLTTSLTYDNETVQLNEILSQQLYGKTINASVSRFEGYQQCPFKHYASHGLRLNERTKYELQNFDLGDIFHSVLKYISDRIYGDFKNLDTKNIQSLTKEALELILPKVQFNLLNSSAYYKYLSKKIGSIVETTLKALKYQGEYSKFVPQRFETGFRKSPKNKGELVAQPLITNQGIPINIRGQIDRIDTYTKGDHSYVNIIDYKSSESSATLDLTKVYYGLQMQMMTYMDIVLQNKERLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDQFQKDYIKNFKMSGLLNRDQEVLDALDIRLEPKYNSDIVPIALTAKGAINQRSSKVADENIIYQLIEHNKKNFIETASHIMDGHTEVAPLKYKQVLPCQFCNYKSVCHVDGLIDSKRYRTVDESIKPLDLIQQLRNEGGERHDSN
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: CASP5_SOYBN
Sequence: MDSGKEGEAPAATSSPESRRTRSNGKVKAFADAAPPSATVVSTKATPLPRGGWKKGVAILDFIIRLGAIGSALGAAAIMGNSEQILPFFTQFFQFHAQWDDFPMFQFFVFANGAAGGFLILSLPFSIVCIVRPYTVGPRLLLVILDILMMALVMAAASSAAAVVYLAHNGSQDANWIAICQQFTDFCQVTSEAVVASFVAAFLLICLIVVSSVALKRG
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 5, GmCASP5.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: CLL5_ARATH
Sequence: MKRSISPDPFSSTKSPKLVHHSPDDGGAEGNPYRLPFTLSDENLSCLPISQAREPPPIFNLDPNSVKDTQDRNKLYLAKAWDLLKPAIKIILDDDEYKKPGDVLCFTTIFRAVKRACLGDPRQSELVFNLVKHECEPHIAELIQSLEKNCSGSDDPSVFLPHVYNRWLDFKRKMSLVSDVAMYQTLNGLTLWDVGQKLFHKQLSMAPQLQDQVITGILRLITDERLGKAANNTSDLLKNLMDMFRMQWQCTYVYKDPFLDSTSKFYAEEAEQVLQRSDISHYLKYVERTFLAEEEKCDKHYFFFSSSRSRLMKVLKSQLLEAHSSFLEEGFMLLMDESLIDDLRRMYRLFSMVDSEDYIDRILRAYILAKGEGARQEGSLQELHTSIDKIWHQCFGQDDLLDKTIRDCFEGFGLHVPGEFSDQLQWIDDDDDED
What are the official names of this protein?
Cullin-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: PFLB_STAAW
Sequence: MLETNKNHATAWQGFKNGRWNRHVDVREFIQLNYTLYEGNDSFLAGPTEATSKLWEQVMQLSKEERERGGMWDMDTKVASTITSHDAGYLDKDLETIVGVQTEKPFKRSMQPFGGIRMAKAACEAYGYELDEETEKIFTDYRKTHNQGVFDAYSREMLNCRKAGVITGLPDAYGRGRIIGDYRRVALYGVDFLMEEKMHDFNTMSTEMSEDVIRLREELSEQYRALKELKELGQKYGFDLSRPAENFKEAVQWLYLAYLAAIKEQNGAAMSLGRTSTFLDIYAERDLKAGVITESEVQEIIDHFIMKLRIVKFARTPDYNELFSGDPTWVTESIGGVGIDGRPLVTKNSFRFLHSLDNLGPAPEPNLTVLWSVRLPDNFKTYCAKMSIKTSSIQYENDDIMRESYGDDYGIACCVSAMTIGKQMQFFGARANLAKTLLYAINGGKDEKSGAQVGPNFEGINSEVLEYDEVFKKFDQMMDWLAGVYINSLNVIHYMHDKYSYERIEMALHDTEIVRTMATGIAGLSVAADSLSAIKYAQVKPIRNEEGLVVDFEIEGDFPKYGNNDDRVDDIAVDLVERFMTKLRSHKTYRDSEHTMSVLTITSNVVYGKKTGNTPDGRKAGEPFAPGANPMHGRDQKGALSSLSSVAKIPYDCCKDGISNTFSIVPKSLGKEPEDQNRNLTSMLDGYAMQCGHHLNINVFNRETLIDAMEHPEEYPQLTIRVSGYAVNFIKLTREQQLDVISRTFHESM
What is the function of this protein?
Catalyzes the conversion of pyruvate to formate and acetyl-CoA.
What are the official names of this protein?
Formate acetyltransferase, Pyruvate formate-lyase.
What is the protein family that this protein belongs to?
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNC_PSEF5
Sequence: MKPYPIQFVSIVIPVYNEEQSLPELLRRTEAACRQLKHEFEIVLVDDGSRDESANILQAAAEREDSPVVAVILNRNYGQHAAIMAGFEQCRGDVVITLDADLQNPPEEIPRLVAQAELGYDVVGTVRNNRQDSAFRRWPSKLINLAVQRSTGVAMSDYGCMLRAYRRTIIDAMLACTERSTFIPILANSFARHTTEVLVEHAEREHGDSKYSPMRLINLMFDLITCMTTTPLRLLSIIGFGMAGLGALFALMLIVLRLIFGATWAGDGTFVLFAVLFVFTGGQFIGMGLLGEYLGRMYSDVRARPRFFIEKVLRSQPAAPAPAVTVDGLTSTHTDQVSP
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSH3L_ARATH
Sequence: MVVATTIALYASPASTVCSTAHQINAHISCDLDLNSRSSSASSSTSSPTIGGLSLLFSGASVKSSSSSSSSHPSVGEELASIRHDRSEDRTLSGSFCYSPSKFIGSSYLKRDHQSPVSVLHGPISSGNSPPMRISRDRNLDGGSALRVGSSRLFNGFVRKAIGSCVDYDTDSVLVDEQLPFTMDDGFEGERRQPYARDLLRRAQLKHKIFEDESVIKAFYEAEKAHRGQMRATGDPYLQHCVETAMLLADIGANSTVVVAGILHDTLDDSFMSYDYILRTFGSGVADLVEGVSQLSKLARENNTACKTVEADRLHTMFLAMADARAVLIKLADRLHNMMTLYALPPVKRQRFAKETLEIFAPLANRLGISSWKVKLENLCFKHLHPDQHHEMSDMLEDSFDEAMITSAIEKLEQALKKEGISYHVVSGRHKSLYSIYCKMLKKKLTMDEIHDIHGLRLIVDNEKDCYKALGVVHKLWSEVPGKLKDYISHPKFNGYQSLHTVVMGDGTIPLEVQIRTKEMHLQAEFGFAAHWRYKEGDCKHSSFVLQMVEWARWVVTWHFETMSKDGSSICSSEPLCSFPSHAEDCPFSYKPSGNQEGPVYVIVIENEKMSVQEFPENSTVSDLLRRAGPGSSRWSMYSIPAKEELRPRLNQTPVSDLKCKLKMGDVVELTPAIPDKSLTEYREEIQRMYDRGLAFSRPHRAATGTMVGWGS
What is the function of this protein?
Probable ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase that may be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
What are the official names of this protein?
Probable GTP diphosphokinase RSH3, chloroplastic, RelA/SpoT homolog 3, AtRSH3, ppGpp synthetase RSH3.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KHSE_HELHP
Sequence: MVISVPATSANLGPGFDTLGLALKLHNTFSITPSKLSSIHISGEGEDRPKLRIDNVFIKIFNEILALHNYPMQPFKFSFHNAIPISRGLGSSSAVIVGAIVGAYHIMQKPINKSEILQLALSYENHPDNITPALYGGFNVSMLDSSLKTKEQVINVQALLPTDIKAVVVIPNVAISTKFSRRSLPKKYSTKDAVFNLSHACMLSAAFITHKWELLRVASQDRFHQELRMKNIPALFNVQKIALENGALLSTLSGSGSSFLNICYCDDSGNLAHILQKHFPKFRVIELEFDNIGATLIES
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_PEDPA
Sequence: MSYASEVKKELTSLEVHEKNAKAELMALIRMNGAIGINNRQLTLNTQTENPAIARRIYSLLKEFYHLEAELSVRRKMKLKKNNLYIVRLRTGVKELLNDLSILKDDFQINEKVPEGLLTEESELRSYLRGAFLASGSVNNPETSRYHLEIYSLYESHNQMIADWINKYNLNARTTERRSGYIVYLKEAEHIADFLQLIGATNSMLKFEDVRIMRDMRNSVNRLVNCETANLNKVANASMKQINNIQFIDETVGLGELPPKLREVAEARLIHREVSLKELGELVPGGPISKSGINHRLRKINQYAEKLRA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: GCST_COLP3
Sequence: MTNKTVLHAKHLASGAKMVDFFGWDMPINYGSQIEEHHAVRTDAGMFDVSHMTIVDVQGADAKAFLRRLVINDVAKLATPGKALYTGMLNEEGGVIDDLIIYFFSDTDYRLVVNSATRVKDLAWMTKQSTGFDITITERPEFGMLAVQGPEAKAKVAKLLTAEQIEAVEGMKPFFGVQVGDLFIATTGYTGEDGYEIIVPNNSAEDFWQKLLDEGVVPCGLGARDTLRLEAGMNLYGLDMDETVSPLAANMAWTISWEPTDRDFIGRDVLTAQKAAGDQPKLVGLVLEAKGVLRSHQVVVTEFGNGEITSGTFSPTLGHSVALARVPRSVKVGDTIEVEMRKKLIKVQVTKPSFVRNGKKVF
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: SGO1_XENLA
Sequence: MVKERCPKQAFQDSLEDIKERMKEKRIKKLAKVATVNKTLCTKVQILNSGSTAIKNYKANNTALALALEAEKLKTRQAQDLILGLKREHQRLIFEIFMLRRRLQSQQGRDTAESKLASLKDIIAKVTHNLLETASLLEPAHLLCSSANNNTPNPSKVEEKLSSGASAILRLPSHAPISDTLPKNVIPNRLEPEQRNFKDKVVLEANRNTAGVNRQSRGRRSHSNQPSFTSRLEECNNEDKTESGATMNKNVSLRRRASSLNICLEESLPLEDTNVNSEHTVVETERPFPTEEFSNESRTDREIDNVDNPASPLKVKCFPHANGSKMTGLASEAKQTSNKNKEEPRVGRERVKKGKAERVAVSQMKKPWENSKPRARSKSRDRSASKKSVAKEKMNSSLNSGDAFDFACEESIHVTPFRQNKQEESQNESSLEISSSEGELDDSLYKPYKDKSKNKNLKPDIAPVPLRSRSKRNTARKNSIAENELMSDVQAEANEKKITRNGLKRKSENSFTESAETYREKSFMPTCINTNNAIAENPEVKVFSDECNGGIIYTADEPSGASTPRISLSDVTNLPGNTDAKKHINLLFNEDEMKRSSTPSRKRRCKVSINYAEPKLSGKLRRGDPFTDSEFLQSPIFKNESKRNSLNRQSLSRYNEVFVGCRR
What is the function of this protein?
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.  May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase.  May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
What are the official names of this protein?
Shugoshin 1, Shugoshin-like 1.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to the centromere. At anaphase, it dissociates from centromeres when chromatids separate. Localizes to kinetochores.
Protein: FPG_METSB
Sequence: MPELPEVETVRRGLEPVMVGARILSVDQRRPDLRFPFPDRFPERLAGRRILALGRRAKYLLADLDDGDVLIMHLGMSGSFRVEQAGPAKTLSPRGAPPKNAAHDHVVFTLTSGGRIVYNDPRRFGFMQIAARADLAAHPLFRSLGVEPLGNELSGAALARLFAGKTTSLKAALLDQSLVAGLGNIYVCEALHRAGLSPLRQAGSLTKKSGRPTERANRLADTIREVLEEAVAAGGSSLRDHRQTNGALGYFQHNFRVYDRALHPCPTPGCKGEISRITQGGRSSFFCSMCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RNPH_SACEN
Sequence: MARADGRSDDALREVRITRGYQDWPAGSVLVEFGRTRVLCAASVQEGVPRWRAGSGLGWVTAEYAMLPSSTNTRSARESVKGRIGGRTHEISRLVGRSLRACIDLAALGENTIALDCDVIQADGGTRTAAITGAYVALADAITWLSAAGRLTDPKPLSCSIAAVSVGVVDGRVRLDLPYEEDSRAEVDMNVVATDHGTLVEVQGTGEGATFTRSTMDKMIDFALAGCSELSRIQSEALAAPYPGELPGGAA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RNZ_LIMF3
Sequence: MQIEFLGTGAGSPSKQRNVSSLALRLLEERNAIWLFDCGEATQHQILHTTIRPRKVEKIFITHLHGDHIFGLPGFLSSRSFQGGDEPLTIYGPKGIKDFVQTALKVSESRLSYPLKFVELTGDGEVFKDQTFTVTARRLDHKIASFGYRVEEAAHPGELMVEKVRQAGIPSGPLYGQLKRGEVVTLPDGRTVDGHDFIGAPQPGRIVAILGDTRVTDNAVKLAKGADVLVHEATFAKNEQRLAHNYYHSTSVQAATVAKKAGAQRLLLNHISARYVGRYANELAYQVRDIFEQTRVVNDLDVIEIPFKER
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: U17LF_HUMAN
Sequence: MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIDKNVQYPECLDMKLYMSQTNSGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQWSQWKYRPTRRGAHTHAHTQTHT
What is the function of this protein?
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 17-like protein 15.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP17 subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum.
Protein: PROA_SYNS9
Sequence: MNTVPEPSAELLARAGAVRLAAVELGQTNNGQRSRALHAMADALQERSSLIVAANVQDLERSEAEGLASALMARLKLDATKLQAAIDGVRKVASLPDPLGLRQLHRELDTDLVLERITVPLGVVGVIFEARPDAVVQIASLAIRSGNGALLKGGSEARCTNEAVMDALRAGLAREESDVSPDALALLTTREESLGLLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGVCHLYVDAAADVMKATRVAVDSKTQYPAACNAIETLLVHRSIATAFLAAAVPAFQAAGVTLRGDAESQSLGVNESAQEEDWSTEYLDLTLSVRVVDDLACATEHIRRYGSRHTEVILTEDLATADRFLAAVDSAGVYHNCSSRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGNGHIAADYAAGRRSFTHQDLPL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE2_HYPNA
Sequence: MTHPVVRFAPSPTGRLHVGNVRTALINWMFSRGQQGKFILRIDDTDLERSTAEHEEALKVDLTWLGLTWDDSFSQSHRFANYDAAADKLRALHLLYPCYETAEELDVKRKIAQTRGRPPVYDRAALSLTAQDRADLEAKGRKPHWRFKLSGERVEWNDLVRGPQSIDTASVSDPILIREDGSYLYTLPSVVDDIEAGITHVVRGEDHVTNSGAQIEIFMALGGKAPEMAHTPLLIGADGAALSKRIGSLSMGELRARGYEPMAICSHLAKLGTSDNIEARATLEQLCEEFSFSKIGRAPARFDDNDLNALNAALVHAMPFEAVRERLITLDARAASEPFWLAVRENCTFVADAISWVDMVYGSPAPLVAEEDREFISGAAMYLPEGELTTESWSAWTNALKAATGRKGRGLFMPLRKALTGAEHGPEMSAVLPLIGREKVLQRLS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_DELAS
Sequence: MENILGLVALACGLIVGLGAIGASIGIALMGGKFLESSARQPELINELQTKMFILAGLIDAAFLIGVAIALLFAFANPFVLA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NORW_SHISS
Sequence: MSNGIVIIGSGFAARQLVKNIRKQDASIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAGQFNLHLFPHTWVTDIDAEAHVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDHQRSIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNDDIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC4_PAPAN
Sequence: MSLLRNRLQDLPALCLCVLVLACIGACQSEAYEGTPSPPPKLKMSHWSLVTGRMKELLEPVLKRTRDRWQWFWSPSTFRGFMQTYYDDHLRDLGPRTKAWLLKSKESLLNKTHSLCPRIVCGDKDQG
What is the function of this protein?
May participate in lipoprotein metabolism.
What are the official names of this protein?
Apolipoprotein C-IV, Apo-CIV, ApoC-IV, Apolipoprotein C4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GRPE_CHLT2
Sequence: MTETPNTSSEEIQTSEPSPDNELQVLQQENANLKAELQEQNDRYLMALAEAENSRKRLQKERTEMMQYAVENALMDFLPPIESMEKALGFASQTSEEVKNWAIGFQMILQQFKQIFEEKGVVEYSSKGELFNPYLHEAVEIEETTTIPEGTILEEFTKGYKIGDRPIRVAKVKVAKLPAKGNSDSNEEKE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHD_ECOLU
Sequence: MENAKMNSLIAQYPLVKDLVALQETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLEDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAEQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNATHLVWATGGGMVPEEEMEQYLAKGRS
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: AP4A_RAT
Sequence: MALRACGLIIFRRHLIPKVDNTTIEFLLLQASDGIHHWTPPKGHVDPGENDLETALRETQEETGIEASQLIVLEGFRRELNYVARKKPKTVIYWLAEVKDYDVEIRLSQEHQAYRWLGLDEACQLAQFEEMKATLQEGHQFLCSTPA
What is the function of this protein?
Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity).  Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, Ap4A hydrolase, Ap4Aase, Diadenosine tetraphosphatase, Nucleoside diphosphate-linked moiety X motif 2, Nudix motif 2.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: PSBE_CUSGR
Sequence: MSGNTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTENQQGIPLITGRFEPLEEQNEFSRRSQ
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.