PharMolix/UniProtQA huggingface dataset:
Protein: JAK_DROME
Sequence: MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQSPPNQPTDAE
What is the function of this protein?
Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein.  Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner.  Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.
What are the official names of this protein?
Tyrosine-protein kinase hopscotch.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Protein: SYC_NITMU
Sequence: MLKIHNSLAREKQEFIPLTPGKVKVYVCGMTVYDYCHLGHARVMVVFDMVQRWFRANRFDVTYVRNITDIDDKIIRRAQENKESIEALTARFIQAMEEDAAALGVEPPSWEPRATRHVEDMIAMIQVLVDKKLAYPASNGDVYYAVHRFPGYGKLSGKSLDELRAGERVIVDPHKNDPLDFVLWKAAKPGEPQWDSPWGPGRPGWHIECSAMGEHYLGEHFDIHGGGQDLQFPHHENEIAQSEGAHGHPFVNYWMHNGFVRVNDEKMSKSLGNFFTVREILAHFQPEVVRFFILRAHYRSPLNYADMQLEDAGRALDRLYTALKGIEVHDEVEIDWDDPYASRFREAMNDDFNTPEALAVLFDLATEVNKTRLPRDIALMKALGGVLGLLQQDPWKYFQQADSEDPAFAPEKVEQLIQQRLVARANKDYREADRIRKELMEANIILEDGPHGTTWRRATGLSTL
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGEF_MOUSE
Sequence: METKNSEDWGKPQRKSESSSRKSNHGPAEMRPALPPENREAPETGEETQNEEPRRLIPIQRHSLFNRAVRHRHKARSTSERRASDQADLPKMGKSVNERSAFNLPQGRLSPWRTPAQRDTGAQEASESSSTPGNGTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQVGEDAGEEEEEEEEGEEEELASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ
What is the function of this protein?
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42.  Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis.  Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation.  Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
What are the official names of this protein?
Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Cell projection, growth cone. Note=Associated with membranes. Localizes to axonal growth cones (By similarity).
Protein: ASTB_BURO1
Sequence: MNAQEANFDGLVGPTHNYAGLSFGNVASLNNEKSAANPKAAAKQGLRKMKQLADLGFAQGVLPPQERPSLRLLRELGFSGKDADVIAKAAKQAPELLAAASSASAMWTANAATVSPSADTSDGRVHFTPANLCSKLHRAIEHEATRRTLSTLFADPTHFAVHEALTGTPALGDEGAANHTRFCAEYGKPGIEFFVYGRAEYRRGPEPKRFPARQTFEASRAVAHRHGLAEEATVYAQQDPDVIDAGVFHNDVISVGNRDTLFTHERAFVNKQAIYDTLTAALDARGARLNVIEVPDAAVSVNDAVTSYLFNSQLLSRADGSQVLVVPQECRENARVAAYLDQLAAGNGPIHDVLVFDLRESMKNGGGPACLRLRVVLNDAERAAVTSNVWINDTLFASLDAWIDKHYRDRLAPEDLADPALLDESRTALDELTQILRVGSLYDFQR
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: ATPG_BARQU
Sequence: MASLKDLRDRIASVKATQKITKAMQMVAAARLHRVQEAAQSARPYAQRMAAILANVATDVDTIDVPPLMRGTGRNDVHLLVVCTAERGLCGAFNMQIARRARQQIKALLSAGKIVKILTVGKKGADILSRDYKALMIDHIDLRSVKRVGFAEAAIISQKIIDLFDKDTFDVCTLFYSEFVSVINQRPVAFGLIPMGSPKGAVEAEDVTQKVDENKNLQSIVYDYEPDVASLLEELVPRNLSVQIFQALLENVAGEMGAKVTAMDNASRNAGEMINKLTVAYNRQRQAQITTELIEIIAGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VATE_CLOBH
Sequence: MSNLENLTSKIIEDANKEAEELLSEAKKEENKIVDEKVKKGNKAKEQIIEKSKREAKTKAERIISNTHLKIRNNKLEAKQEMINKVFDEAVIKLQNLSKDEYLDFVKSSILSLDIEGDEEIIISPNDKDKMDVNFMLTLNNKLKAKGKKGLLKISNENRNIKGGFILYKNGIEINNSFEALVDSLRDELEQEIIEALFS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: IR3IP_XENLA
Sequence: MAFTLYTLLQAALLCVNAVAVLHEERFLSKIGWGVDHGIGGFGEEPGMKSQLMNLIRSVRTVMRVPLIIVNSVTIVLLLLFG
What is the function of this protein?
Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size.  Required for secretion of extracellular matrix proteins.  Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity).  Acts as a regulator of the unfolded protein response (UPR) (By similarity).
What are the official names of this protein?
Immediate early response 3-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the YOS1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL5_ECODH
Sequence: MAKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: PYRB3_SHEHH
Sequence: MSNPIYNKHIISISDLSRSELELIVSTANDLKQNPRPDLLKNKVVASCFFEASTRTRLSFETAVQRLGGSVIGFPDSGNTSLGKKGETLADSVQVISSYCDAFFMRHNQEGAARLASEFSSAPVINGGDGSNQHPTQTLLDLFSIYETQGTLEKLQVAFVGDLKYGRTVHSLTQALSLFDCEFHFIAPAALSMPDYIIDELKAKGCKYTLHDHLDGVLPNLDILYMTRVQKERFDETEYQHLKSSFILNANMLEGVKENLKVLHPLPRIDEITTDVDSTPYAYYFQQAKNGVYARQALLALVLTNEFGDK
What are the official names of this protein?
Aspartate carbamoyltransferase 3, Aspartate transcarbamylase 3, ATCase 3.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: ITAD_RAT
Sequence: MAGGVVILLCGWVLASCHGSNLDVEEPIVFREDAASFGQTVVQFGGSRLVVGAPLEAVAVNQTGRLYDCAPATGMCQPIVLRSPLEAVNMSLGLSLVTATNNAQLLACGPTAQRACVKNMYAKGSCLLLGSSLQFIQAVPASMPECPRQEMDIAFLIDGSGSINQRDFAQMKDFVKALMGEFASTSTLFSLMQYSNILKTHFTFTEFKNILDPQSLVDPIVQLQGLTYTATGIRTVMEELFHSKNGSRKSAKKILLVITDGQKYRDPLEYSDVIPAADKAGIIRYAIGVGDAFQEPTALKELNTIGSAPPQDHVFKVGNFAALRSIQRQLQEKIFAIEGTQSRSSSSFQHEMSQEGFSSALTSDGPVLGAVGSFSWSGGAFLYPPNTRPTFINMSQENVDMRDSYLGYSTAVAFWKGVHSLILGAPRHQHTGKVVIFTQEARHWRPKSEVRGTQIGSYFGASLCSVDVDRDGSTDLVLIGAPHYYEQTRGGQVSVFPVPGVRGRWQCEATLHGEQGHPWGRFGVALTVLGDVNGDNLADVAIGAPGEEESRGAVYIFHGASRLEIMPSPSQRVTGSQLSLRLQYFGQSLSGGQDLTQDGLVDLAVGAQGHVLLLRSLPLLKVELSIRFAPMEVAKAVYQCWERTPTVLEAGEATVCLTVHKGSPDLLGNVQGSVRYDLALDPGRLISRAIFDETKNCTLTGRKTLGLGDHCETVKLLLPDCVEDAVSPIILRLNFSLVRDSASPRNLHPVLAVGSQDHITASLPFEKNCKQELLCEGDLGISFNFSGLQVLVVGGSPELTVTVTVWNEGEDSYGTLVKFYYPAGLSYRRVTGTQQPHQYPLRLACEAEPAAQEDLRSSSCSINHPIFREGAKTTFMITFDVSYKAFLGDRLLLRAKASSENNKPDTNKTAFQLELPVKYTVYTLISRQEDSTNHVNFSSSHGGRRQEAAHRYRVNNLSPLKLAVRVNFWVPVLLNGVAVWDVTLSSPAQGVSCVSQMKPPQNPDFLTQIQRRSVLDCSIADCLHFRCDIPSLDIQDELDFILRGNLSFGWVSQTLQEKVLLVSEAEITFDTSVYSQLPGQEAFLRAQVETTLEEYVVYEPIFLVAGSSVGGLLLLALITVVLYKLGFFKRQYKEMLDGKAADPVTAGQADFGCETPPYLVS
What is the function of this protein?
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.  May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
What are the official names of this protein?
Integrin alpha-D.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CYB_SYNCA
Sequence: MTHIRKSHPLMKILNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVAHICXDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMIHLLFLHETGSNNPTGISSDTDKIPFHPYYTIKDILGALLLILALMLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILIIMPLLHTSKQRSMMFRPLSQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPTASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YFIR_ECOLI
Sequence: MRFSHRLFLLLILLLTGAPILAQEPSDVAKNVRMMVSGIVSYTRWPALSGPPKLCIFSSSRFSTALQENAATSLPYLPVIIHTQQEAMISGCNGFYFGNESPTFQMELTEQYPSKALLLIAEQNTECIIGSAFCLIIHNNDVRFAVNLDALSRSGVKVNPDVLMLARKKNDG
What is the function of this protein?
Repressor of the cell division arrest function of DgcN.  Prevents DgcN relocation to the midcell.
What are the official names of this protein?
Protein YfiR.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS14_JANSC
Sequence: MAKEAMIERQKKRERLVAKYADKRAALKEIARDEDLPMEDRFKARLKLAKLPRNSSATRLNNRCQLTGRPRAYYRKLKMSRIKLRDLASNGQIPGMVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: LPXA_RALPJ
Sequence: MTQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNSIGHFASVGGRPQDMKYRDEPTQLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYVHIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQFVRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIAAQIAQTDDAPTREVLTAFADFIAATKRGIVR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_LUMTE
Sequence: MNIPFFTSVLMSLVLALLAMAFYTLMERKFLGYFHLRKGPNKVGLMGLPQPFADAIKLFVKEQAKPNPSNQTPFLFAPTMGLVLALLMWVIYPHSHQSFFIQFSVLYFLCVSSMNVYTTFLAGWSSNSKYALLGALRGVAQTISYEVSMSLILLSSLIILSTMDFTKMFSYSWILFMFIPLAVVWFITNLAETNRTPFDFAEGESELVSGFNVEYSAGLFALIFMAEYANILIMSLFTSVIFMSTCASGMASDLVLILQTITLAMLFVWVRATYPRMRYDHLMNLTWKSFLPLSLALLMMSIPIAMML
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VILI_MOUSE
Sequence: MTKLNAQVKGSLNITTPGIQIWRIEAMQMVPVPSSTFGSFFDGDCYVVLAIHKTSSTLSYDIHYWIGQDSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGNESETFRSYFKQGLVIRKGGVASGMKHVETNSCDVQRLLHVKGKRNVLAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLRGMALAKEIRDQERGGRTYVGVVDGEKEGDSPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAALKLYHVSDSEGKLVVREVATRPLTQDLLKHEDCYILDQGGLKIFVWKGKNANAQERSGAMSQALNFIKAKQYPPSTQVEVQNDGAESPIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDALTMHVQPQVAAQQKMVDDGSGEVQVWRIEDLELVPVESKWLGHFYGGDCYLLLYTYLIGEKQHYLLYIWQGSQASQDEIAASAYQAVLLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRKNNLEPVPSTRLFQVRGTNADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENQVITPRLFECSNQTGRFLATEIFDFNQDDLEEEDVFLLDVWDQVFFWIGKHANEEEKKAAATTVQEYLKTHPGNRDLETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYDDLKAELGNSGDWSQIADEVMSPKVDVFTANTSLSSGPLPTFPLEQLVNKSVEDLPEGVDPSRKEEHLSTEDFTRALGMTPAAFSALPRWKQQNIKKEKGLF
What is the function of this protein?
Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments.  Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing.  Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2.  Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities.  Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity.  Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis.  Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium.  Appears to regulate cell death by maintaining mitochondrial integrity.  Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair.  Upon S. flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.
What are the official names of this protein?
Villin-1.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, microvillus. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, filopodium tip. Cell projection, filopodium. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment (By similarity). Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia.
Protein: FETP_SHELP
Sequence: MARTVNCQYLKKEADGLAFQLYPGELGKRIFDNISQEAWSLWQAKQTMLINEKKLNMMNVDDRKFLEEQMVNFLFEGKEVEIEGYVPQKDDE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: MAFA2_NEIMF
Sequence: MKTLLLLIPLVLTACGTLTGIPAHGGGKRFAVEQELVAASSRAAVKEMDLSALKGRKAALYVSVMGDQGSGNISGGRYSIDALIRGGYHNNPESATQYSYPAYDTTATTKADALSSVTTSTSLLNAPAAALTRNSGRKGERSAGLSVNGTGDYRNETLLANPRDVSFLTNLIQTVFYLRGIEVVPPEYADTDVFVTVDVFGTVRSRTELHLYNAETLKAQTKLEYFAVDRDSRKLLIAPETAAYESQYQEQYALWMGPYSVGKTVKASDRLMVDFSDITPYGDTTAQNRPDFKQNNGKKPDVGNEVIRRRKGG
What are the official names of this protein?
Adhesin MafA 2.
What is the protein family that this protein belongs to?
Belongs to the MafA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: DXR_BACC1
Sequence: MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKIVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKESIIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQERFRCLRFAYEAGKTGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDATTRRFVMEQI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: TRMD_FRATM
Sequence: MKFGIISIFPEMFKAINDFGVTARAIKDSKVSISCFNPRDYTTDRHATVDDTSFGGGAGMVMKYQPLSAAIEDAKNTLGCGTKVVYLSPQGSIFNHRKAQELLQNDSLILLCGRYEGVDERLIQDYVDEEISVGDFVLSGGELPAMLVMDSLIRLLPEVLGNKESVVEDSFYDGLLDYPHYTKPAVLPNGNAVPDVLLSGNHKEIAKWRRKQKLIRTYERRKDLIECLCLSAKDKQILDDYKIDKVSTKGEE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAM_AGRFC
Sequence: MPELEKHAFRMKLFAGKEVEYKKRHDEIWPELVALLHEAGVSDYSIHLDPETSILFGVLTRPKVHGMAALPEHPVMKKWWAHMADIMESNPDNSPVAKDLVTVFHLP
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SHIFL
Sequence: MAIERTFSIIKPNAVAKNVIGNIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSVESAAREIAYFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT18A_ARATH
Sequence: MATVSSSSWPNPNPNPDSTSASDSDSTFPSHRDRVDEPDSLDSFSSMSLNSDEPNQTSNQSPLSPPTPNLPVMPPPSVLHLSFNQDHACFAVGTDRGFRILNCDPFREIFRRDFDRGGGVAVVEMLFRCNILALVGGGPDPQYPPNKVMIWDDHQGRCIGELSFRSDVRSVRLRRDRIIVVLEQKIFVYNFSDLKLMHQIETIANPKGLCAVSQGVGSMVLVCPGLQKGQVRIEHYASKRTKFVMAHDSRIACFALTQDGHLLATASSKGTLVRIFNTVDGTLRQEVRRGADRAEIYSLAFSSNAQWLAVSSDKGTVHVFGLKVNSGSQVKDSSRIAPDATPSSPSSSLSLFKGVLPRYFSSEWSVAQFRLVEGTQYIAAFGHQKNTVVILGMDGSFYRCQFDPVNGGEMSQLEYHNCLKPPSVF
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions.  Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens.
What are the official names of this protein?
Autophagy-related protein 18a, AtATG18a, Protein PEROXISOME UNUSUAL POSITIONING 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole.