PharMolix/UniProtQA huggingface dataset:
Protein: CYB_CONCR
Sequence: MTNIRKTHPLMKIINDSFIDLPAPSNISSWWNFGSLLGVCLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYMFMETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPSGLSSDSDKIPFHPYYTIKDILGVLILIMILTSLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAFLPLLHTAKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFTIILVLMPLASIVENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GPDA_BURP0
Sequence: MLSMKVAVLGAGAWGTALAAHLAVRHDTLLWARDAALVAELAARRENARYLGGVALPPGLRYEADLATALSHAQADDALCVIAAPVAGLRALCRAMRDARRVPAHFVWVCKGFEADTRRLPHQMVAEELPDHASYGVLSGPSFAREVAQGLPVALTVASASAACRERTLAAFHHGAMRIYTGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALVTRGLAEMSRLGVALGGRAETFTGLTGLGDLILTATGDLSRNRSVGLQLAAGRSLDDILAALGHVAEGVRCARAVLSIARERGVDMPITEAVCAVLFDGVAPRDAVSGLLRRDAKAE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_MARN8
Sequence: MTELSRIRNFSIIAHIDHGKSTLADRFIQICGGLTDREMAEQVLDSMDLERERGITIKAQSVTLNYKAKDGETYKLNFIDTPGHVDFSYEVSRSLYACEGALLVVDAGQGVEAQSVANCYTAIEQGLEVVPVLNKMDLPQAEPERVAAEIEDIIGIDASDAVRCSAKSGLGVEDVLEDLIKKIPPPKGDRSAPLQALIIDSWFDNYLGVVSLVRVTEGVLRKGDKIVIKSTKKAWNADKVGVFNPKPTDTDVLEAGDVGFVVAGIKDIHGAPVGDTIVHQKFAEETPMLPGFKKVKPQVYAGLFPVSADDYDDFRDALEKLTLNDASLFFEPENSDALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVIYEVVTKQGETLSVDNPSRLPDIGSIEEMREPIVEANILVPQEHLGNVIALCEEKRGVQKNMHFMSTQVQLTYELPMAEVVMDFFDRIKSASRGFASLDYHFVRFQSANLVRLDVLINGDRVDALALIVHRDLSHRKGRQLIEKMKELIPRQMFDIAIQAAIGTQVVSRVTVKALRKNVTAKCYGGDVSRKKKLLQKQKEGKKRMKQLGNVEVPQEAFLAVLKVDN
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CTHL3_CAPHI
Sequence: RFRLPFRRPPIRIHPPPFYPPFRRFL
What is the function of this protein?
Has potent antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa.  Less active against the Gram-positive bacteria S. aureus and L. monocytogenes.  Has low hemolytic activity towards human red blood cells.
What are the official names of this protein?
Cathelicidin-3.4, Bactenecin-3.4, Bac3.4, ChBac3.4.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDC_SALEP
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTTQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNAGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y892_THET2
Sequence: MILTTTHEIEGRRIERYLGIVFGEAIVGANVLRDLLAQIRDIVGGRSGAYEAELRRARETALAEMAEAARRLGADAVVGVDLDYEVLGSGNSMLMVTASGTAVKLAP
What are the official names of this protein?
UPF0145 protein TT_C0892.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: NTPP_MYCSS
Sequence: MTTRVVLGSASSGRLKVLRQAGIEPLVVVSGVDEDAIVAALGAAAPPDQVVCALAAAKAASVVESLPTEVATDCVVIGCDSMLQLDGRLTGKPGTPAAARAQWQQMAGRSGELYTGHCLVRVRDGVAGRREVEAAATTVRFGTPPPADLAAYVDSGEPLGVAGAFTLDGLGGWFLDGVDGDPSNVIGLSLPLVRRMLDRLDLSVPALWTR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_DEIGD
Sequence: MAFRDVLDIEVAAGNGGDGSMSFHRAKYLEKGGPDGGHGGRGGSVILRAIEGVESLERLVGQRKFKAPNGAYGEGRLRQGADGEDLYIDVPVGTTAFDRDSGKVIADLVRVGQEKVIARGGLGGRGNSTFVTSTRQAPRFAELGTPGEKRRVRLELRLIADVGLVGYPNAGKSSLLAALSRANPAIADYPFTTLSPILGVVESADGEKRFTMADIPGIIEGASEGKGLGLEFLRHISRTRLLVYVLDVTRDPAEELRQLQTELRTYDPSLLENVALIALNKIELVDADLAAMVEDELAEFGLPVLPVSAKTGQGLPELRQALFDLLPDRELWARTHALEEEPEEVREEPLTLTFREDAPEKPGEAPERVWEVHGGGFEARIVRFARHLEDAAEYLSNLFKRQGLYNALKRAGAREGDTVEIGSFRFEYYADED
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXLYS_BPT7
Sequence: MDKYDKNVPSDYDGLFQKAADANGVSYDLLRKVAWTESRFVPTAKSKTGPLGMMQFTKATAKALGLRVTDGPDDDRLNPELAINAAAKQLAGLVGKFDGDELKAALAYNQGEGRLGNPQLEAYSKGDFASISEEGRNYMRNLLDVAKSPMAGQLETFGGITPKGKGIPAEVGLAGIGHKQKVTQELPESTSFDVKGIEQEATAKPFAKDFWETHGETLDEYNSRSTFFGFKNAAEAELSNSVAGMAFRAGRLDNGFDVFKDTITPTRWNSHIWTPEELEKIRTEVKNPAYINVVTGGSPENLDDLIKLANENFENDSRAAEAGLGAKLSAGIIGAGVDPLSYVPMVGVTGKGFKLINKALVVGAESAALNVASEGLRTSVAGGDADYAGAALGGFVFGAGMSAISDAVAAGLKRSKPEAEFDNEFIGPMMRLEARETARNANSADLSRMNTENMKFEGEHNGVPYEDLPTERGAVVLHDGSVLSASNPINPKTLKEFSEVDPEKAARGIKLAGFTEIGLKTLGSDDADIRRVAIDLVRSPTGMQSGASGKFGATASDIHERLHGTDQRTYNDLYKAMSDAMKDPEFSTGGAKMSREETRYTIYRRAALAIERPELQKALTPSERIVMDIIKRHFDTKRELMENPAIFGNTKAVSIFPESRHKGTYVPHVYDRHAKALMIQRYGAEGLQEGIARSWMNSYVSRPEVKARVDEMLKELHGVKEVTPEMVEKYAMDKAYGISHSDQFTNSSIIEENIEGLVGIENNSFLEARNLFDSDLSITMPDGQQFSVNDLRDFDMFRIMPAYDRRVNGDIAIMGSTGKTTKELKDEILALKAKAEGDGKKTGEVHALMDTVKILTGRARRNQDTVWETSLRAINDLGFFAKNAYMGAQNITEIAGMIVTGNVRALGHGIPILRDTLYKSKPVSAKELKELHASLFGKEVDQLIRPKRADIVQRLREATDTGPAVANIVGTLKYSTQELAARSPWTKLLNGTTNYLLDAARQGMLGDVISATLTGKTTRWEKEGFLRGASVTPEQMAGIKSLIKEHMVRGEDGKFTVKDKQAFSMDPRAMDLWRLADKVADEAMLRPHKVSLQDSHAFGALGKMVMQFKSFTIKSLNSKFLRTFYDGYKNNRAIDAALSIITSMGLAGGFYAMAAHVKAYALPKEKRKEYLERALDPTMIAHAALSRSSQLGAPLAMVDLVGGVLGFESSKMARSTILPKDTVKERDPNKPYTSREVMGAMGSNLLEQMPSAGFVANVGATLMNAAGVVNSPNKATEQDFMTGLMNSTKELVPNDPLTQQLVLKIYEANGVNLRERRK
What is the function of this protein?
Component of the cylindrical core that assembles on the inner surface of the capsid during capsid formation and plays a role in viral DNA ejection into the host cell.  The inner core is composed of stacked rings of gp14, gp15 and gp16 proteins.  Following binding to the host cell surface, the internal core is diassembled and gp16 is ejected along with gp14 and gp15 into the infected cell.  Gp16 probably inserts in the host inner membrane and remains associated with gp15.  The gp15-gp16 complex binds to both the viral DNA and the host inner membrane, probably escorting the leading end of the genome through the periplasm and controlling the extend of DNA translocated into the host cell.  Functions as an exolysin that catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycans allowing the local digestion of the bacterial peptidoglycan wall.
What are the official names of this protein?
Peptidoglycan transglycosylase gp16, Internal core protein gp16.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Virion. Host cell inner membrane; Single- pass membrane protein. Note=The gp15- gp16 complex spans the periplasm and the cytoplasmic membrane.
Protein: PURL_SULIA
Sequence: MGLNLLPIEMDDIRKRLDREPNEIEWRVIDAVWSEHCSYKSSKIFLKSFSIDSPNVIMGIKDWQDAGAVDIGDGWAIVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVGNLKIRKNVWLLKNIIAGIAAYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIKPSIVDKAGLKLVLAGLTGIDGLGGASFASRKLSGEDEIGAVQIADPFAGKIILDITLEIADKVEAIKDLGGGGLAVAVTEMANGLGAIVDIEKIPLRVKNMNPADVIISETQERMLYAVEEKNVEEVCKAFEEYEYPCSVIGEITSEPIIKFRYFGKDLVSLPTNALLEPPKFLWPIKNVRKNVEEKNVDLPLESTIYTVLSHPDLVSKEWVYSQFDYEVNTSTVVKPGDANGAVVSLPNGKLLAIKVDGNPDLCSEDAYECGKGIVAEAYRNLATVGARGMVAVDHLQFGDPKKPEVYYTFVEAIRGIGEATRFFNIPIVGGKVSFYNENSQGKPIKPTPLIVMAGLVQGKLLKNRVEDSSYVVLLGYTRKELGGSLLSKIFKVPSQAPKVRLQEDLLSSEVVIDAINEEKITFAKDISRGGLAASLFNIIVHGYGVEISTKSILSDTDNVVENLFSESSGRFVILTNEPEWIVEKSRSKGIVASIIGKVNKKTSILTIDNTDYDLKTIVNNYFNFLEEVIGNG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF3_ARATH
Sequence: MPRSRINGNFIDKTFTIVADILLRVIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIQQGDSEMAEAWFAQAAEYWKQAITLTPGNYIEAQNWLTITRRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: NTPP_SYNSC
Sequence: MLASASPARRRLLEQAGIPHQVRVSGVDEDQIQHAEPVELVKLLAQAKAQAVAQRLDPSGDAEITAVLGCDSVLSFEGQVFGKPSGPVEAIERWQRMAGSCGSLLTGHCLIRRRQPEVLACVETLVRFAPLSQAEIEAYVASGEPLQCAGGFALEGRGGLCIDGLDGCYSNVIGLSLPWLRTVL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PESC_YEAST
Sequence: MRIKKKNTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKFREHKTFARKLTRALGRGEVSSAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQVSSKIINDAQKICNQWLAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWLVPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDSGLIYPPKLDLKKDKIISGLSSYILESRQEDSLLKLDPTEIEEDVKVESLDASTLKSALNADEANTDETEKEEEQEKKQEKEQEKEQNEETELDTFEDNNKNKGDILIQPSKYDSPVASLFSAFVFYVSREVPIDILEFLILSCGGNVISEAAMDQIENKKDIDMSKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINKGELVPANKYLPGEALPPHLSPWGDAIGYDPTAPVEEGEEEESESESESEDQVEEEDQEVVAGEEDDDDDEELQAQKELELEAQGIKYSETSEADKDVNKSKNKKRKVDEEEEEKKLKMIMMSNKQKKLYKKMKYSNAKKEEQAENLKKKKKQIAKQKAKLNKLDSKK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7, Ribosomal RNA-processing protein 13.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Accumulates in the nucleolus in response to rapamycin treatment.
Protein: UREF_PROS9
Sequence: MKKNHLVKYLLISPSLPVGGFCYSEGLESYLKIKNLEEPDHIRNLITNELKIGQIRIEAKCLIEFFDIFVELKIANNINKNRRRLLSLDKWLLSFRDTVEIRDQQTQMAKSLFELTKEFGFEYLYEKNKNISWSLAWSWACFSFQINKLEMIENFIYAWTANQLSAAIRLIPMGSIKAQTIQLELLDLISEVSQEIVDSNINDLYVGNISLSMAQQNHNDLYTKLFRN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREM1_RAT
Sequence: MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
What is the function of this protein?
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop.  Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity).  Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity).  Acts as inhibitor of monocyte chemotaxis (PubMed:15528323).  Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
What are the official names of this protein?
Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMN_PELPD
Sequence: MTEKTDLKNLTLPALEQFLRGQGKERFRATQVFKWIYQHDARSFQEMTNISKDLRAELEAKAYISNLEPEAVEVGGDGTRKYLFGLEDGNSVESVLIPDEGRNTLCISSQVGCAMGCAFCLTGTFRLTRNLTTAEIVNQIMAVRRDVEIRNIVMMGMGEPLHNLDNVIPAIHIMIDGNGLQLSNRRVTVSTCGLAPEMERLGRELPNVNLAVSLNATTDELRDRIMPINRRYPLKELLSACREFPLPGRRKVTFEYVMLGGLNDTLEDAKRLLRLTSDIPNKVNLIPFNEFQGCEFRSPTRAAIDAFHKYLIDRHVTVITRDSRGSDISAACGQLKGKLDAARQPTE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG079_VACCC
Sequence: MSKVIKKRVETSPRPTASSDSLQTCAGVIEYAKSISKSNAKCIEYVTLNASQYANCSSISIKLTDSLSSQMTSTFIMLEGETKLYKNKSKQDRSDGYFLKIKVTAASPMLYQLLEAVYGNIKHKERIPNSLHSLSVETITEKTFKDESIFINKLNGAMVEYVSAGESSILRSIEGELESLSKRERQLAKAIITPIVFYRSGTETKITFALKKLIIDREVVANVIGLSGDSERVSMTENVEEDLARNLGLVDIDDEYDEDSDKEKPIFNV
What is the function of this protein?
Plays an essential role in viral DNA replication.  Binds to ssDNA with high affinity and localizes to cytoplasmic factories where nascent viral genomes accumulate.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.
What are the official names of this protein?
Protein OPG079, Protein I3.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG079 family.
Protein: THIM_HELPS
Sequence: MLKELRQKRPLVHNITNYVVAQFVANGLLALGASPLMSDAIAEMQDLAKISDALAINIGTLNERTILCAKEAIKHYKALNKPIVLDPVGCSASALRHGTSLELLESEGISVLRGNAAELGSLVGISCGSKGLDSHYATTPIEIVKLVAQKYSVIAVMTGKTDYVSDGKKVFSITGGSEYLALITGAGCLHAAACASFLSLRKDPLDSMAQLCALYKQAAFNAQKKVSENNGSNGSFLFYFLDALSLPIKLENSLIKEEL
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RL24_PELUB
Sequence: MIKKGLKVRVLTGRDKKKEGEVIEIDRPNNRAKVQGINIVKKHVKTTKEKKGGIVSKESFIHISNLKLIDEKAKTKKTEAKK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MURD_PECAS
Sequence: MVDYQGKKVVIIGLGLTGLSCVDFFLARGVVPRVVDTRISPPGLDKLPEQVERHLGSLNEDWLMSADLIVASPGVALATPILCDAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMARAAGWQVGVGGNIGLPALQLLEHPAQLYVLELSSFQLETTTSLHAAAATILNVTEDHTNRYPFGLQQYRAAKLHIYEHADLCVVNADDALTMPVRGADARCRSFGVDVGDYHLNRQQGETWLRVDGERVLNTREIKLVGQHNYTNALAALALADAVKIPRASALTALTSFTGLPHRFQMAFERNGVRWINDSKATNVGSTEAALSGLAVDGTLHLLLGGDGKSADFSPLVPYLQGERIRLYCFGRDGQQLAALRPEIAEQTETMEQAMRVIAERIRPGDMVLLSPACASLDQFRSFEQRGDEFARLAEELG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_BIFAA
Sequence: MAGQKIRIRLKSYDHEVIDQSAKKIVETVTNAGATVVGPVPLPTEKNVLVVIRSPHKYKDSREHFEMRTHKRLIDIVDPTPKAVDSLMHIDLPADVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PUB1_SCHPO
Sequence: MSNSAQSRRIRVTIVAADGLYKRDVFRFPDPFAVLTVDGEQTHTTTAIKKTLNPYWNETFEVNVTDNSTIAIQVFDQKKFKKKGQGFLGVINLRVGDVLDLAIGGDEMLTRDLKKSNENTVVHGKIIINLSTTAQSTLQVPSSAASGARTQRTSITNDPQSSQSSSVSRNPASSRAGSPTRDNAPAASPASSEPRTFSSFEDQYGRLPPGWERRTDNLGRTYYVDHNTRSTTWIRPNLSSVAGAAAAELHSSASSANVTEGVQPSSSNAARRTEASVLTSNATTAGSGELPPGWEQRYTPEGRPYFVDHNTRTTTWVDPRRQQYIRSYGGPNNATIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFLSQPALHPLPGQCHIKVRRNHIFEDSYAEIMRQSATDLKKRLMIKFDGEDGLDYGGLSREYFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGINPEHLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEYYRSLVWILDNDITGVLDLTFSVEDNCFGEVVTIDLKPNGRNIEVTEENKREYVDLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTDYRSYSENDQIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRKFTIEKAGEPNKLPKAHTCFNRLDLPPYTSKKDLDHKLSIAVEETIGFGQE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Regulates ubiquitination of cdc25.
What are the official names of this protein?
E3 ubiquitin-protein ligase pub1, HECT-type E3 ubiquitin transferase pub1.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm.
Protein: RIMK_ECO7I
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGVASVARITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: DB130_PANTR
Sequence: MKLHSLISVLLLFVTLIPKGKTGVIPGQKQCIALKGVCRDKLCSTLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP
What is the function of this protein?
Antimicrobial host-defense peptide.
What are the official names of this protein?
Beta-defensin 130, Defensin, beta 130.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3SA5_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMFMVSNKMVPVKRGCIDVCPKNSALVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 5, Cardiotoxin 5, CTX5.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.