PharMolix/UniProtQA huggingface dataset:
Protein: DXR_CHLCV
Sequence: MKHLAILGSTGSIGQQTLKIIRSLPHLFKVVALASYGNNKDVFFEQIREFSPSIVSVYDEQSYFEISKEFPNIEVFLGEEGLLAAATAGEVDTIVAASSGVVALPAIIEAMKLGKTLALANKEVLVSAGEIIKEIAKQYQTRILPIDSEHNALYQCLEGKNTSEVKKLVLTASGGPLLYKSKEDLSRVTIRDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLENAEIDAVVHPQSLIHGMVEFQDGTVLSVMNPPSMLFPIQHALTAPKRYPAPHKGIDFSVKQTLEFFPVDEERFPSIGLARQVLREKGSSGPFLNAANEVLVQRFLTEEIAWCDILDKLTRLMENYRVSSCSSLDDVFAVDKEARALAQEI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: MC5R_SHEEP
Sequence: MNSSFHLHFLDLGLNATEGNLSGLSVRNASSPCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHIPMYFFVGSLAVADMLVSLSNFWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCRLRYQRIMTGRRSGAIIAGIWAFCTSCGTVFIVYYESTYVVVCLIAMFLTMLLLMASLYTHMFLLARTHVRRIAALPGHSSVRQRTGVKGAITLAMLLGVFIICWAPFFLHLILMISCPQNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQGFRTPCRFPSTY
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  This receptor is a possible mediator of the immunomodulation properties of melanocortins.
What are the official names of this protein?
Melanocortin receptor 5, MC5-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLH1_RAT
Sequence: MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
What is the function of this protein?
Also exhibits a dipeptidyl-peptidase IV type activity.  In vitro, cleaves Gly-Pro-AMC.
What are the official names of this protein?
Glutamate carboxypeptidase 2, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen homolog, Pteroylpoly-gamma-glutamate carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: RECA_MYCBO
Sequence: MTQTPDREKALELAVAQIEKSYGKGSVMRLGDEARQPISVIPTGSIALDVALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHALDPDYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDKIGVMFGSPETTTGGKALKFYASVRMDVRRVETLKDGTNAVGNRTRVKVVKNKCLAEGTRIFDPVTGTTHRIEDVVDGRKPIHVVAAAKDGTLHARPVVSWFDQGTRDVIGLRIAGGAIVWATPDHKVLTEYGWRAAGELRKGDRVAQPRRFDGFGDSAPIPADHARLLGYLIGDGRDGWVGGKTPINFINVQRALIDDVTRIAATLGCAAHPQGRISLAIAHRPGERNGVADLCQQAGIYGKLAWEKTIPNWFFEPDIAADIVGNLLFGLFESDGWVSREQTGALRVGYTTTSEQLAHQIHWLLLRFGVGSTVRDYDPTQKRPSIVNGRRIQSKRQVFEVRISGMDNVTAFAESVPMWGPRGAALIQAIPEATQGRRRGSQATYLAAEMTDAVLNYLDERGVTAQEAAAMIGVASGDPRGGMKQVLGASRLRRDRVQALADALDDKFLHDMLAEELRYSVIREVLPTRRARTFDLEVEELHTLVAEGVVVHNCSPPFKQAEFDILYGKGISREGSLIDMGVDQGLIRKSGAWFTYEGEQLGQGKENARNFLVENADVADEIEKKIKEKLGIGAVVTDDPSNDGVLPAPVDF
What is the function of this protein?
PI-MboI is an endonuclease.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WALK_STAHJ
Sequence: MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNSLEKELTNNFMKNIKQYATQLEVNIERIYRDDPSNAQKEVQSLLNEYANRQEIEEIRFIDKDQIIMATAKISSHNMINQKVNDNSVQKALSLGESNSHNVLKDYGSGKERIWIYNLPVKNGNETIGNIYIESNINDVYNQLNNINQIFIIGTAISLFITVILGFFIARTITRPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRVRIVNDMAIKMLGMSKEDLIGYYMLSVLNLEDEFSLDEIQENNDSFLLDINEDEGIIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGVWKDDNLAPSFLSVTREETERMIRLVNDLLQLSKMDNESEQITKEIVDFNMFINKIINRHEMAAKDTTFVREIPSETIFTEIDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKQNALYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIDDGDWDEE
What is the function of this protein?
Member of the two-component regulatory system WalK/WalR.  WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR.
What are the official names of this protein?
Sensor protein kinase WalK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD_PHEZH
Sequence: MTAKIIDGKVLAERLRGQVADEVARLRADYRLQPGLAVVLVGEDPASQVYVRSKGEHSLAVGMHSVTHRLPADTRQDELLRLVAELNADPLIHGILVQLPLPKHLDEKAVIAAISPDKDVDGLHVVNAGRLASGLPALVPCTPLGCLIMLRETLGDLTGKRAVVVGRSLLVGKPVAQLLLQADCTVTIAHSRTVDLPAVCREADILVAAVGRPRMIRGDWIKPGATVIDVGINRVPFDDPEKAAQGKTKLVGDVHYKEALQVAGAVTPVPGGVGLMTVACLLQNTVTAAKRLAGIEG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SOK2_ARATH
Sequence: MEAVRCRRGRENNKSPERIIRSLNHHQHDEELEEEVKTKKPIFRRVQVVYYLTRNGHLEHPHFIEVISPVNQPLRLRDVMNRLTILRGKCMTSQYAWSCKRSYRNGFVWNDLAENDVIYPSDCAEYVLKGSEITDKFQEVHVNRPLSGSIQEAPKSRLLRSKLKPQNRTASFDDAELYVGEEEEEEDGEYELYEEKTSYTSSTTPQSRCSRGVSTETMESTEQKPNLTKTEQDLQVRSDSSDLTRSNPVVKPRRHEVSTRVEDGDPVEPGSGRGSMWLQMISCGHIATKYYAPSVMNPRQKEENLRKGVLCKNIVKKTVVDDEREMIRFMSENPRFGNPQAEEKEYFSGSIVESVSQERVTAEPSLRRSNSFNEERSKIVEMAKETKKKEERSMAKVKCIPRTCLMSSSKQIKK
What is the function of this protein?
Part of a three-gene cluster containing FLC, UFC and DFC, which is coordinately regulated in response to vernalization (PubMed:15186749, PubMed:18156133).  Also regulated by FLX (PubMed:15186749).  SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization (PubMed:30737509, PubMed:32004461).
What are the official names of this protein?
Protein SOSEKI 2, AtSOK2, Protein UPSTREAM OF FLC.
What is the protein family that this protein belongs to?
Belongs to the SOSEKI family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=SOSEKI proteins integrate apical-basal and radial organismal axes to localize to polar cell edges, pointing towards the epidermis, mainly to inner basal edges.
Protein: URE2_STAA1
Sequence: MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDAYAGVFGDNGAENVNKKGGKRS
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_STRU0
Sequence: MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: PP441_ARATH
Sequence: MINYSSCSYLLKLCRTLKHLHQFHAQFITSGRISNDFKQNSVFANVLFAITSISPSASASKEVVSYATSVFRFITNPSTFCFNTIIRICTLHEPSSLSSKRFFVEMRRRSVPPDFHTFPFVFKACAAKKNGDLTLVKTLHCQALRFGLLSDLFTLNTLIRVYSLIAPIDSALQLFDENPQRDVVTYNVLIDGLVKAREIVRARELFDSMPLRDLVSWNSLISGYAQMNHCREAIKLFDEMVALGLKPDNVAIVSTLSACAQSGDWQKGKAIHDYTKRKRLFIDSFLATGLVDFYAKCGFIDTAMEIFELCSDKTLFTWNAMITGLAMHGNGELTVDYFRKMVSSGIKPDGVTFISVLVGCSHSGLVDEARNLFDQMRSLYDVNREMKHYGCMADLLGRAGLIEEAAEMIEQMPKDGGNREKLLAWSGLLGGCRIHGNIEIAEKAANRVKALSPEDGGVYKVMVEMYANAERWEEVVKVREIIDRDKKVKKNVGFSKVLS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At5g61800.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: LPXH_ECO5E
Sequence: MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRTKVHKPWLQTLFLALPLFVRKRIAVRMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PUR7_SHIFL
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: YEB0_YEAST
Sequence: MGKYSSCRISNIFIVISKINEENSIYLVSLYYSFSTKCRAISMQEPGISSDSKFFSLFLIIRKVSVASDCRQLYECKKSNENIWEYFKRRLETRLSSFSIILSAVFPDVLFTFLFS
What are the official names of this protein?
Putative uncharacterized protein YEL010W.
Protein: ATPD_ECO57
Sequence: MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MED7_PIG
Sequence: MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKAEPMDADDSNNCTGQSDQQRENSGHRRDQIIEKDAALCVLIDEMNERP
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7, Cofactor required for Sp1 transcriptional activation subunit 9, CRSP complex subunit 9, Mediator complex subunit 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSHC_SACEN
Sequence: MQPWSSVPVPKVPGTARPLRLFDTAAGEVRPVTAGRTARMYVCGITPYDATHLGHAATYLAFDLVHRIWLDNGHDVHYVQNVTDIDDPLLERANRDNEDWVVLAMRETALFREDMEALRVVPPTDFIGAVESIPEIEEAVGKLLASGAAYRVDDDEYPDVYFRHSATGRFGYESNYDEATMLDLSAERGGDPDRKGKEHPLDALLWRMARDGEPSWESELGPGRPGWHLECSVIALNRLGMGFDVQGGGSDLAFPHHEFSAAHAEALAGDHPFARHYCHAGMIGLDGEKMSKSKGNLVFVSRLRGDRVDPMAIRLALLDGHYRSDRSWTADALTKGSARLARWREAVALEAGPSAEPVVERLRDRLSDDLDTERALLAVDAWVDEALCRRGGDAEAPAAIRDAVDGLLGVQL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: CHI2_PINMG
Sequence: MYLTIWLVPLLAVGTWGQKFNRFCHYNSWALSRNPQHGLVPEDIDPFLCTHMILGFAEIDESGLRLKDPNHYQQQYLYQRIVRLRRINPRLNMILSVGGWDKSQEGYSKLVSSRENIIFFTKWIITYLRRHDFDGLDLDWEYPTFKGSPMVDKKKFVDLVENLAYEFDIEEIPDIKWKLTLTWTADPLESVRTSAYDIKGIASKVHYVNLKMYDFHGHWDDPLRVNHHSPLTSSNSPRNVNELAKTWVKAGVRIEKLILGIPFFGRSFTLKTANMSAPGSPAVGPGSDFGDGIPIHNLCHIIRGGTKELYLPEKKVPYIVSGSEWIGYDNPRSVMEKAQLVFNNALAGVMIYSLDMDDHHGTCGKKWPMMMAVIHGLNAYMEYIDSKHKSLELTYNKKILRARVSLRNYRRRNQQGKVAEMEQRIRNLEQELQQSMGNMAYERQQAQAMLNRGVSLPPIEQQSWSW
What are the official names of this protein?
Putative chitinase 2, Chitinase-like protein 3, Clp3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LNT_CHRVO
Sequence: MLNAAGGAGCDPSSPTATSPMRILILLLAAALAGAFTLFAFAPYRLFWLMPLCLAALVELLQREPRRAFWLGYAWGLGAYVSNFRWIYDSLHDVAGLPAWIAAPLVLLLPAYLALYPGLASWLACRIDPRPGVRWLLAFPAAWELGEWLRGWVMTGFPWGAAGYSQITESPLAGYAPLGGIHLVNYLVALSAAALAMLARAGMRQRIGILIAAALAWGSGVWLRDIEWTTPAGKPITVALAQGNIAQELKWSPENLENSLLTYYRQVAMTRADLMILPETALPLFLDDLPSGYLSMMRGEASRAGMALASGIPRRTDDGRGYLNSVVALSDPKMPYYAKDHLVPFGEFVPLPGLIGWIYQHMDMPLSGFTRGGADQPPLTLAGQKVAFNVCYEDSFGEELIGPASRAGMLANVSNLAWFGKSEAMSQHLQLSQARSLETGRYMLRATNNGMTAIIRPDGEISAVAAPFTAQVLTGFAQSRQGLTPYMRFGNLPVVLGCGALLLLALLLGWRRRGQH
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUCM_RABIT
Sequence: VSLSSPTLYPLVSCEGALTDGNLVAMGCLARDFLPSSVTFSWSFKNNSEISSRTVRTFPVVKRGDKYMATSQVLVPSKDVLQGTEEYLVCKVQHSNSNRDLRVSFPVDSELPPNVSVFIPPRDSFSGSGTRKSRLICQATGFSPKQISVSWLRDGQKVESGVLTKPVEAETKGAGPATFSISSMLTITESDWLSQSLYTCRVDHRGIFFDKNVSMSSECSTTPSPGIQVFPIAPSFADTFLSKSARLICLVTDLTTYGSLNISWASHNGKALDTHMNITESHPNATFSAMGEASVCAEDWESGEQFTCTVTHADLPFPLKHTISKSREVAKHPPAVYVLPPAREQLVLRESATVTCLVKGFSPADVFVQWQQRGQPLSSDKYVTSAPAPEPQAPGLYFTHSTLTVTEEDWNSGETFTCVVGHEALPHMVTERTVDKSTEGEVGAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK
What are the official names of this protein?
Ig mu chain C region membrane-bound form.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MPI1B_XENLA
Sequence: MAESHIMSSEAPPKTNTGLNFRTNCRMVLNLLREKDCSVTFSPEQPLTPVTDLAVGFSNLSTFSGETPKRCLDLSNLGDETAPLPTESPDRISSGKVESPKAQFVQFDGLFTPDLGWKAKKCPRGNMNSVLPRLLCSTPSFKKTSGGQRSVSNKENEGELFKSPNCKPVALLLPQEVVDSQFSPTPENKVDISLDEDCEMNILGSPISADPPCLDGAHDDIKMQNLDGFADFFSVDEEEMENPPGAVGNLSSSMAILLSGPLLNQDIEVSNVNNISLNRSRLYRSPSMPEKLDRPMLKRPVRPLDSETPVRVKRRRSTSSSLQPQEENFQPQRRGTSLKKTLSLCDVDISTVLDEDCGHRQLIGDFTKVYALPTVTGRHQDLRYITGETLAALIHGDFSSLVEKIFIIDCRYPYEYDGGHIKGALNLHRQEEVTDYFLKQPLTPTMAQKRLIIIFHCEFSSERGPKMCRFLREEDRARNEYPSLYYPELYLLKGGYKDFFPEYKELCEPQSYCPMHHQDFREELLKFRTKCKTSVGDRKRREQIARIMKL
What is the function of this protein?
This protein functions as a dosage-dependent inducer in mitotic control.  It is a tyrosine protein phosphatase required for progression of the cell cycle.  It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.
What are the official names of this protein?
M-phase inducer phosphatase 1-B.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
Protein: HTRA4_BOVIN
Sequence: MARPLQRPAGLGPFVLLWLLLPAPSGRGVQAGRAWPVPRCPAACEPTRCPPLPRCSVGTAPVLDRCGCCRVCAAAEGEACGGPLGRPCAPGLQCLAPRAPRLLGGRPLGTCGCPAAGATVCGSDGRTYRSLCALRAENRAARLRGALPAVPVQKGDCGDPGTGSAGWLRNKFNFIASVVEKVAPSVVHLQLFRRDRSPLGSEDVPVSSASGFIVSEDGLIVTNAHVLTNQQRIQVELQSGVQYEATVKDVDHKLDLALIKIEPNADLPVLLLGKSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDMDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLAEFHERQLKGKALSQKKYLGLRMLPLTMNLLQEMKRQDPEFPDVASGVFVHEVIQGTAAESSGLKDHDVIVSINGLPVTTTTDVIEAVKANDSLSLLVRRKSQTLILTVTPEIIN
What is the function of this protein?
Serine protease.
What are the official names of this protein?
Serine protease HTR4, High-temperature requirement factor A4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUS10_HUMAN
Sequence: MFPLTEENKHVAQLLLNTGTCPRCIFRFCGVDFHAPYKLPYKELLNELQKFLETEKDELILEVMNPPPKKIRLQELEDSIDNLSQNGEGRISVSHVGSTASKNSNLNVCNVCLGILQEFCEKDFIKKVCQKVEASGFEFTSLVFSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRDDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLAAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFLKQFPCPPNSPKAVCAVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQKKDIEFLNDIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDVESVDVDWPPALDD
What is the function of this protein?
Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933).  In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933).  tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625).  Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933).  In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270).  Binds pri-miRNAs (PubMed:31819270).  Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588).  Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588).
What are the official names of this protein?
tRNA pseudouridine synthase Pus10, Hup10, Coiled-coil domain-containing protein 139, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase Pus10 family.
Protein: GLMM_ALKOO
Sequence: MGKLFGTDGVRGIANRDLTPELAYQLGRIGAYVLNKDNNKRAKVAIGKDTRISGDLLESAMTAGFLSMGVDVISLGVLPTPAVAYLTRHLKADFGVVISASHNPAEYNGIKFFNREGYKLPDEVEEQIEAYILNNRDVDIRMEGKDVGTVTVDEKSIEEYTDFLKTTLDRDFKGLKIAVDAGNGAAYRSAPKLLKELGAEVILINDTPDGMNINKGCGSTNPEVIGALVKEVGADIGISFDGDADRLIAVDENGEVVDGDHIMAICGICLKKQGKLKNDVIVGTVMSNIGLEIAMKEYGCNVVKTKVGDRYVLEEMVQGGYCLGGEQSGHVIFLDYNTTGDGLLTAIQLIATMKAENKKLSELAKVMTSYPQVLVNAKVKNENKEVYQNDAIIMQSITAIENKLAGEGRVLIRPSGTEPLVRVMLEGKNQEELNVLATDLAKLIEQRLN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: GUX1_HYPJR
Sequence: MYRKLAVISAFLATARAQSACTLQSETHPPLTWQKCSSGGTCTQQTGSVVIDANWRWTHATNSSTNCYDGNTWSSTLCPDNETCAKNCCLDGAAYASTYGVTTSGNSLSIGFVTQSAQKNVGARLYLMASDTTYQEFTLLGNEFSFDVDVSQLPCGLNGALYFVSMDADGGVSKYPTNTAGAKYGTGYCDSQCPRDLKFINGQANVEGWEPSSNNANTGIGGHGSCCSEMDIWEANSISEALTPHPCTTVGQEICEGDGCGGTYSDNRYGGTCDPDGCDWNPYRLGNTSFYGPGSSFTLDTTKKLTVVTQFETSGAINRYYVQNGVTFQQPNAELGSYSGNELNDDYCTAEEAEFGGSSFSDKGGLTQFKKATSGGMVLVMSLWDDYYANMLWLDSTYPTNETSSTPGAVRGSCSTSSGVPAQVESQSPNAKVTFSNIKFGPIGSTGNPSGGNPPGGNPPGTTTTRRPATTTGSSPGPTQSHYGQCGGIGYSGPTVCASGTTCQVLNPYYSQCL
What is the function of this protein?
Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose.  The degradation of cellulose involves an interplay between different cellulolytic enzymes.  Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs).  The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain.  Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase, Cellobiohydrolase 7A, Cel7A, Exocellobiohydrolase I, CBHI, Exoglucanase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TCSR3_PAES9
Sequence: MSNLYESIRKYKCGYIEEILNILDMFDPLLNKFQRNSCYEDMKSELSLFMFNLIDNFPLEKDCFKEDKFIINYIYKSLKNKFIQVNKLHQKVKSYETNIDIIWVNNCDYANLLSTVIFEDIIKDLTQNEKNILRKIYLHGLRESEISRELNISRQAVNKTHLRALEKLKN
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (Probable).  Transcriptional regulator specifically required to activate expression of the toxin gene locus, composed of tcsL and tcdE/utxA (PubMed:23873908).
What are the official names of this protein?
RNA polymerase sigma factor TcsR.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: REV_SIVAM
Sequence: MSTGNVDQELIRRYLVVVKKLYEEPIPQTARQRRRRKQQLRTRRAQLRELEGRILKQILDRGPDQLCQGVANLALAEKSESSN
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.