PharMolix/UniProtQA huggingface dataset:
Protein: DNAK_KLEP3
Sequence: MGKIIGIDLGTTNSCVAIMDGTTARVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPYKIVAADNGDAWLDVKGTKTAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEVGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDTRLINYLVDEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDINDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTALINKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEEEIQKMVREAEANAESDRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETSLKGEDKADIEAKMQALAQASQKLMEIAQQQHAQQQAGSADAQASNAKDDDVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CLPX_RHOJR
Sequence: MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAESSEVKLDELPKPAEIRDFLENYVIGQDAAKRTLAVAVYNHYKRIQAGDKGRDARGETVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLERIVSDRVGKRGIGFGAEVRSKAEIDTQDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVQILSEPKNALVKQYNRLFDMDGVELEFTTDALEAIADQAILRGTGARGLRAIMEEVLLPVMYDIPSRDDVEKVVVSAETVNDNVLPTIVPRKPERGERRDKSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NSCB_TRIT1
Sequence: MDQSSSGGSMGGRLPFNQSFWEEFLMGREGHLPALPEISHVSKSVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPVWISRISSFLYTQKIELSYVLLTHWHGDHTGGVPDLISQNSSLSNRIYKNRPDSGQNPITHGQIFSVAGATVRAILTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIEKLPGKLEEYIQHREGRERMMLSALTRQRVQGEGVREGGVKCGLTLNEIVMVIYGRLPQEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQKKRNKVRGCPS
What is the function of this protein?
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997).  The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity).  The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity).  The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity).  The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity).  Neosartoricin B can be converted into two additional compounds neosartoricins C and D (PubMed:23758576).  Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (PubMed:23758576).  On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (PubMed:23758576).  Both of these compounds are novel and possibly represent related metabolites of the gene cluster (PubMed:23758576).
What are the official names of this protein?
Lactamase-like protein nscB, Neosartoricin B biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: MIOA_XENLA
Sequence: MSGSKPDILWAPHHVDRFVVCDSELSLYHIESAASPSSELKAGSLRLSEETTATLLAINSDTPYMKCVAWYPKYDPECLLAVGQANGRVVLTSLGQDHNSKCKDLIGKEFVPKHARQCNTLAWNPQDSNWLAAGLDKHRADFSVLIWDISSKYTPEVAVPAEKVRLAPGDSETCSVVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTNQKMFVNTKAVQGVTVDPHFHDRVASFFEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMVVVTPNRSMSDFTVFERISLAWSPTTSLMWACSRQLYECTEEGKGSSSLDRDIATKMRLRALSRYGLDTEQVWRNHLLAGNDDPQLKSLWYTLHFMKQYAEDIDQKSSGNKGLLVYAGIKAITKSSMGTTESFRHSWTGSDRQADIVHYSSEERCLALQLCGWRTKGADSDMGPFLNSLEQEGEWERAAAIALFNRDIRRAIQILNKGASTGKGNLNLNVVAMALSGYTDEKKSLWREMCSTLRLQLNNPYLCVMFAFLTSEPGVYDGVLYENSMAVRDRVAFSCLFLNDAQLSRYFDKLTNEMKEAGNLEGILLTGLTKDGVDLIESYVDRTGDVQTASYCMLQGSPSDVLKDERVQYWIESYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSSVPHQGRGFSQYGVSGSPTKSKFTSCPGCRKPLPRCALCLINMGNPVSSSPGASKSDEKVDLSKEKKVAKFNNWFTWCHNCRHGGHAGHMLSWFKDHSECPVSACSCKCMQLDTTGNLVPAENVQP
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
GATOR complex protein MIOS-A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat mio family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: MSMB5_PROFL
Sequence: MKVFFSLIVFSFVLATCQGACFQGSFEAKRMDGKSVMPNTCVDIFDSKKHLLVSTWNTDHCYRCECLKSGFSCCHRYGGIGYVEGYKTVDPVTCQHESYRLDDPSQRS
What is the function of this protein?
May serve as a self-defense protein against the toxic effects of the snake venom during accidental envenomation.  Does not show inhibitory activity towards brevilysin H6.
What are the official names of this protein?
Small serum protein 5, SSP-5.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXB_SALA4
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_STRTD
Sequence: MSFYNHKEIEPKWQKYWADHHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPADFTAENIANFKRQINALGFSYDWDREINTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWPESIKDMQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHDLVDAITSPEQAEAVANYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGREIPIWIADYVLASYGTGAVMAVPAHDERDWEFAKQFGLPIVEVLEGGNVEEAAYTEDGPHVNSDFLNGLNKEEAIAKIVAWLEEKGFGQEKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEIVAENNGGLDKVYNETVKSVTEQIELMKFNTAIAQLMVFVNAANKEDKLYVDYAKGFVQLIAPFAPHLAEELWQTLTATGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREELQEVALADEKVKAEIDGKEIVKVIAVPNKLVNIVVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INTU_BOVIN
Sequence: MASLPLCGSVRSPEGLPGDPSSQEDRQDYDPEDPVSGSGSYSPTSTDSNDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEEDDYREGKKYEPKLKRFTKILKSKKLLPKRYNKKNSNASGPVSILKHQSNQKMGVIVQQRHKDVNIYVNPKKLTVTKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGGGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVEVTSENIERVLSCIPGPMQVKLTFENAYAMKKETTQPRQKKAQLNTSDLVKLLWGEEVEGIQQNILNTPHIVMYLTLQLDSETSKEEQEILYHYPVSEASQKLQSVRGIFLTLCDMLENVTGTQVTSSSLLLNRKQIHIAYWKETDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENVPRLDHFFSLFFQRALQPTKLHSSASPSTQQYDASSAVLLDNLPGVRWLTLPQEIKLELDTALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLVIWREVFPRHHLQPSADSNTEVFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASRAIGNPGPDCIYVDQVKTTLHQLEGVDSRINERLASSPTPCLSCADWFLAGSHEKLDNLTTSPILSRLHGASRVATSPTCRRTLFSDYSLKTRKPSPSRSGGPDSGLEGEGVGLSPHTTESQGSHGSEETGALLKVTKKKSALPNPFHLGNLKKDLSEKELDIYNTVKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTVAKEKKKALNGKDHSGSTNSVSSLNPVKEHGVLFECSPENWTDQRKAPPVMAYWVVGRLFLHPKLQELYVCFHDSVTEIAIEMAFKLFFGLTL
What is the function of this protein?
Plays a key role in ciliogenesis and embryonic development.  Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules.  Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension.  Has an indirect effect on hedgehog signaling (By similarity).  Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
What are the official names of this protein?
Protein inturned, Inturned planar cell polarity effector homolog, PDZ domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the inturned family.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Cytoplasm, cytoskeleton, cilium basal body. Note=Enriched at the apical surface in ciliated cells.
Protein: RB18A_LYMST
Sequence: MEEQEIITTLKILIIGESGVGKSSLLLRFTEDTFDPEQAATIGVDFKVKTLTVEGNKTKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVSSKQSFNKLDAWLNELETFSTKHDMVKMLVGNKIDRANHEVTKDEGLKFARKHHMLFIEASAKTNDGVQCAFEELVEKIIQTPGLWETSSKNLTLSNHGPEGQGQSCYCVL
What are the official names of this protein?
Ras-related protein Rab-18A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: THIM1_STRR6
Sequence: MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPADLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVADDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVTGEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVYNIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 1, 4-methyl-5-beta-hydroxyethylthiazole kinase 1, TH kinase 1, Thz kinase 1.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: ATPA_HALOH
Sequence: MNLRPEEISSVIKKQIENYKSELETVSVGTVLDVGDGIAHVYGLDEVMASELLEFPNGVYGMALNLEEDSVGCVLLGDETRVKEGDTVKRTGRVVEVPVGEELLGRIVNSLGQPLDGKGQISVDKYRPVESPAPSVVDRKPVDTPLQTGLKAIDSMIPIGRGQRELIIGDRQTGKTAIAVDTIINQKDQDVICIYVAIGQKASTVAQIAERLKEHGAMDYTVIVSASASEPAPLQYIAPYAGCAIGEYFMYEKNRDVLVVYDDLSKHAVAYRSMSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEDMGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESELFFAGVRPAINVGISVSRVGGAAQTKAMKKVAGTLRLDLSQYRELEAFAQFGSDLDKATQRRLERGERIVEVLKQPQYTPMDMEDQVMIIYTVVNGHLDDIPVDNIERFEDEFLSYIHSNYPEIPETIKKTGDLDDETEEKLTGVIKEFKENFNVKENTLLNVEEGDTGEEENNEGHNKAEQDTEEKDTEEVV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CXA8_HUMAN
Sequence: MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV
What is the function of this protein?
Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells.  They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179).
What are the official names of this protein?
Gap junction alpha-8 protein, Connexin-50, Cx50, Lens fiber protein MP70.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: HEM3_CLOK1
Sequence: MSFRIATRKSKLALVQTDYVIDLLALKFKMQCEKVLIRTEGDRKLDVSLDKIGGKGVFVKDIEKALIEKRAQAAVHSMKDMPNELLDLFEIIAMPVREDVRDVFISPEGIKFLDLPKGAVIGTSSIRRAVQIKNLRHDIEIVPIRGNIETRVRKMKEEKLDGIVLAAAGVKRLGMSEIITEYFNPFEFIPAVGQGAIGVEILKNSEYASTLGKIDNEDIRMGVEAERSFLKKLQGDCHTPVGAYSVIEGEILNITGIFQVGNKLIKKDVCGDKWDYIALGESLGEKIISG
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL36_SALSV
Sequence: MQVLNSLRNAKQRHPDCQIVKRKGRLYVICKTNPRFKAVQGRKKRR
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: ECFA2_STAAM
Sequence: MTIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKAIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKKKLADWHIGLPEIVQLQYDFEQKYQTKLKDIALTEEAFVSLYKEWQHEK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PELI2_MOUSE
Sequence: MFSPGQEEPSAPNKEPVKYRELVVLGYNGALPNGDRGRRKSRFALYKRTYASGVKPSTIHMVSTPQASKAISSRGHHSISYTLSRSQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTVSGGQNEDAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPQGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHSWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6.  Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination.  May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation.  Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
What are the official names of this protein?
E3 ubiquitin-protein ligase pellino homolog 2, Pellino-2, RING-type E3 ubiquitin transferase pellino homolog 2.
What is the protein family that this protein belongs to?
Belongs to the pellino family.
Protein: CDGAP_DROME
Sequence: MSDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGGGSECTLHTGLSQGNGQEHLGQQRVRRISDEKNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTSKTPANKFERSQPMPRDRLQRNSLAESNAGTNNREKISPQFSIRDVTAMFESRSQNQ
What is the function of this protein?
Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42.  Required for optic stalk formation.
What are the official names of this protein?
GTPase-activating protein CdGAPr, d-CdGAPr.
Protein: RL22_BIFAA
Sequence: MEAKAIARHVRVTPRKARRMVDLIRGKKATEAITILKFAPQDASLPVRKVLESAIANARVKADKAGEPFRENDLVVKETYVDEGVTLKRFRARAQGRAARINKRTSHITVVVANKEGNR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RS12_BDEBA
Sequence: MPTINQLIKSERTVQKNQTKSPALDSCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLSNGFEVISYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVLDLQGVNGRLRARSKYGTKRPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: LEUC_ECO81
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RL18_METB6
Sequence: MATGPRYLVAFRRRREGRTDYYQRTKLVVADAPRMVVRRTNRHIIVQLVTAEMEGDKTLVSANSAELEKYGYTGATANTPAAYLTGLLFAAKAKKAGQDSAILDIGLNRATPGARVFAALKGAVDGGLEIPYGESILPSEDRLKGEHIAAYNEKAGDIVKNVEQVAAAIKKELV
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: Y3622_BURM7
Sequence: MMKGQLAGLMKQAQQMQENMKKMQEQLALIEVEGQSGAGLVKVTMTCRNEVRRVAIDPSLLADDKDMLEDLVAAAFNDAVRKAEATSQEKMSGMTSGLPLPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BMA10247_1122.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y090_SYNY3
Sequence: MEFDYLHLYVDDYQSAHRCYQRQWGFTCVNKIITDQGITGIYQQGQILLLISASESSLSRYADYLQKHPPGVGEVAWQVANWQKIQHQLSELQIETTPVIHPLTKAEGLTFLLWGDVHHSIYPVRSELNQNKTLHGVGLTTIDHVVLNIAADQFTQASQWYQQVFGWSVQQSFTVNTPHSGLYSEALASANGKVQFNLNCPTNNSSQIQTFLANNHGAGIQHVAFSTTSITRTVAHLRERGVNFLKIPTGYYQQQRNSSYFNYASLDWDTLQCLEILLDDQDNTGERLLLQIFSQPCYGVGTLFWEIIERRHRAKGFGQGNFQALYEAVETLEKQLEVP
What are the official names of this protein?
Uncharacterized protein slr0090.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: HIS7_THIDA
Sequence: MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLHIDAHHTVEDTGITLGQAFAKALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVDYTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAHHQAETIFKAFGRALRMAVETDARLGDVTPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTLG_BORPE
Sequence: MLNRPSSPDGGEAHAWPPDPEIPVFANAEHAHRRPLRWMFALVAVALSCLLATGIWRSRAAPPHAATQTVAPAGQALPPGRIFTVHPREPEPAPLPDMPAAPDPILPQPRPAPPVPPPPIRAPYDYDEPAPRRDSAALKSGPAMMVATAARLGQTERAGMADDGVSADAATLIGRNVSRATRSGGRDYRLLPGTFIDCILQTRIVTNVPGLTTCIVSRDVYSASGKRVLVPRGTTVVGEYRADLAQGSQRIYVAWSRLFMPSGLTIELASPAVDGTGAAGLPGVVDDKFAQRFGGALLLSVLGDATSYMLARATDARHGVNVNLTAAGTMNSLAASALNNTINIPPTLYKNHGDQIGILVARPLDFSILRGTNE
What is the function of this protein?
Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
What are the official names of this protein?
Type IV secretion system protein PtlG, Pertussis toxin liberation protein G.
What is the protein family that this protein belongs to?
Belongs to the TrbI/VirB10 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.