PharMolix/UniProtQA huggingface dataset:
Protein: CH60_HALHL
Sequence: MAAKEIRFSDDARQRMMSGVNQLANAVKVTLGPRGRNAVLEKSFGAPTVTKDGVSVAKEIELEDHFENMGAQMLKEVSSQTSDVAGDGTTTATVLAQAILREGMKSLAAGMSPMELKKGIEKATEAASNYLSDELSKPCEDDNSIAQVGTISANSDEAVGRIIADAMGKVGKEGVITVEEGSGLDNELDVVEGMQFDRGYLSPYFVTDQQTMKAELEDAAILLHDKKISNIRDLLPLLEGVAKQNRPLLIIAEEVEGEALATLVVNNLRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVISDEVGMTLENATVDDLGTAKKVQISKEETTIVGGAGRHDDIMARVEQIRAQMEESTSDYDKEKLQERVAKLVGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGTALIRALAALEGLSGANEEQTQGIALVRRAMEEPLRQLVLNAGEDASVVVNKVREGTGNHGYNVATGEYGDLVQAGVLDPTKVTRSALQNAASVAALMLTTEAMVADLPKKDDEGGGGDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_SHIBS
Sequence: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRSVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSREGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPRGDISEFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEITAEIEVGRVYTGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRIRLSIKEATEQSQPAAAPEAPAAEQGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSMB_PIG
Sequence: MKFLLGTLVVLATFVTLCNSQCYFIPNQSLKPNECQDLKGVSHPLNSVWKTKDCEECTCGQNAISCCNTAAIPTGYDTNKCQKILNKKTCTYTVVEKKDPGKTCDVTGWVL
What are the official names of this protein?
Beta-microseminoprotein, Prostate secreted seminal plasma protein, Prostate secretory protein of 94 amino acids, PSP-94, PSP94, TS507.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted. Note=Sperm surface.
Protein: UBIG_XANCP
Sequence: MNPNPQSTSSNFHQTELDKFAALANRWWDADGPQKPLHALNPVRLDYVAARVALPGARVLDVGCGGGLLSEAMARLGAQVTAIDLAPELVKVARLHSLESSVQVDYRVQSVEDLAAEQPGSFDAVTCMEMLEHVPDPLAIIRACASLLKPGGTLFLSTLNRTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPSELAAWLRTAELQLQDVSGMLYEPWRNRARLSSRTEVNYLACAVKP
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: Y352_THEMA
Sequence: MKKVMELVDVWKIYDLGEVKVEALRGVSFEVFEGEYVIIIGPSGSGKSTLLHILGCLDRPTKGKVLIEGEEVSRMGDRRLAQVRNRKIGFVFQSYNLLPRLTALENVELPMIYAGVPAKERKRRAKELLELVGLGDRLHHRPNQLSGGQQQRVAIARALANDPVFILADEPTGNLDTKTGEEILELFRKLHEMGKTLVVVTHNLEMVDEGTCIVRIRDGRIEGIERRGVVYGDT
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein TM_0352.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: SMC_METVO
Sequence: MISISEIHLKNFKSFKNTKLKIPDGFTAILGPNGSGKSNTIDGICFVLGKTSAKSLRAGKFNQLITYHNGKRADYAEVTLFFDNINREIPIDSDKVGICRKVKLNGDNNYYVVWYEVEKQNTKINTESSQKKTSKASKVEKRRRMKKNEVLDLLSKISLIADGPNIILQGDLLRIIDTSPNERRKILDEVSGVAEFDEKSEKAKKELSQAREYIEKIDIRINEVRANLEKLKKEKEDAEKYTVYNKKLKVTKYILTSKKVEFLKMVLDETKDEIEALKETKNCYIQDISNIDSEIIGLKVKINELVNELNEKGSEEVMELHKSIKELEVNLNNDKNALENAIDDLKHTLKMEESKNNDLNETKEKINNIRIDTLKKEAEAKVLIKEIEKLNEERQNLEKKVEQSESQVKALKNQESKLSERINDTQKELYGLKNELNQLENTLNNRTFDYQKNNETIENLTNQIAEFSDLEDTKKLYKELEDIAVELEFSKKKLQEKITERNDSQSKLDNLHSEYVKENARIKTLKDMENFSLDRAVKGVLDAKLPGVVDIAGNLAKTKGEYKTAIEVAGGARLNHIVVKKMDDGSRAINYLKQKRLGRATFLPMDRIKGMDAKDISDTGIIGKAIDLVEFDIKYTNVFKFIFGNTHIVDNLENAKKLSLKYKARFVTLEGEVIEPSGAMVGGNIRRNSAIKVDIDMKKLTNLSEDIKELEQILSNVKDEIERLNNKINTCSTRKLELDNRLKIARDQEFKKEEITKSNNLKIKELNMLNSKIDDEISELTDEKEILSQKVQNLDNKLSEVMGQRERIVNEIKSYENSELSKRIKEIDHKIRENESSKNTLENEIKKGAILVKEVLIPKISELNSNIKSLADKKNMFKNSVEIYKSNIESNSSILSDKRGKYEELTKGLKDLTDKKECYELEIENLQNNKEELREKATDIDNQVNVINVDRAKYETRLEEEERKLYLCDTLENIEDISDEMIEETYSLEIDDLERNQALLESSIKKLEPVNMRAIEDYDFINERYEELFGKRKEYEQEEGKYLQLISEVQKRKKETFMKTYDRVAENYEQIYGEIGGNGKLSLENEEDPFSGGLLIDASPMNKQLQNLDVMSGGEKSLTALAFLFAIQRLNPSPFYVLDEVDAALDTKNASLIGDMISNASKESQFIVISHREQMISKSNVMYGVCMENGLSKIVSVKL
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLC_NEIMA
Sequence: MFSLEAWIGLRYLRAKKRNGFMSFITMVSIAGIALGVTALIVVLSVMNGFQKEIRGQLLNVAPHAEIGYIDNTDTDWRNLLRFTENRKGILAAAPYVSNQALLANAGEIRGVQIRGILPSEERKVVEYGDKMPAGKFEDLIPGEFDIILGVGLAEALGAEVGNKVTVITPEGNVTPAGVVPRLKQFTVVGLVKTGVYEVDNSLAMTHIQDARVLYRLDKEVAGLRLKLADPQNAPALTAKLIPEAQRDTVWVRDWTFSNRSYFEAVELEKRMMFIILTLIIAVAAFNLVSSLVMAVTEKQADIAILRTLGLSPGGVMKIFMVQGAFSGFFGTLAGVVCGVLLGWNVGRVVAFFENLLGVHLINSQVYFIDYLPSDVDMGDVALIACISLGLSFVATLYPSRRASKTQPAEALRYE
What is the function of this protein?
Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane.  Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity).
What are the official names of this protein?
Lipoprotein-releasing system transmembrane protein LolC.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NRDR_EHRCJ
Sequence: MKCPFCNNINTQVKDSRAIEDDILIRRRRICLVCNSRFTTIEKLLLRSFMVIKKNGETEPFNKQKLLSSILIATKKRPVSHEGINVMVNNIFYELEGKKENAVPTDVIGKMVMDNLFKLDKVAYVRFASVYMNFKNINDFSNIIAKIINEQIL
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RECO_DESVV
Sequence: MDFTDQALVLRVGRFREADLWVRFLCRQRGIISAFAFGGCRSRRRFCGCLDIFNVVLMRVQGTRGGLYQSLQEATLLKGPDRLRRDWRRYGVAVNCLRFIEALGAGPDGADSAFTLTLEMLELLETVDVVPPLLPLLFRARFAFEQGYAPRFESCASCGEPFDGTAKDGGARFHVRDGVLYCGRCSAPTGATVAISRETLDALRFVQDNSPLRWSELCFSPTGRRECSRAVDGFIQYHIGLTWENGTFRRL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MK12_RAT
Sequence: MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVTGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKMLVLDAEQRVTAAEALAHPYFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2.  Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.  Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets.  Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.  Phosphorylates DLG1.  Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes.  This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment.  Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure.  MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle.  C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation.  MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability.  MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
What are the official names of this protein?
Mitogen-activated protein kinase 12, MAP kinase 12, MAPK 12, Extracellular signal-regulated kinase 6, ERK-6, Mitogen-activated protein kinase p38 gamma, MAP kinase p38 gamma, Stress-activated protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma.
Protein: IFR_SOYBN
Sequence: MAGKDRILILGPTGAIGRHIVWASVKAGNPTFVLVRNTPGSNNRVNLVKAANPETKEELIESFKNSGVNLIQGDMNDHESLVNAIKQVDVVICAFGRLLIEDQLKIIAAIKEAGNVKRFFPSEFGLDVDRHDSVDPVREVFEEKARIRRIIEAEGIPYTYLCCHAFTGYFLRNLAQIDITVPPRDKVFILGDGNVKGAFVTEADVGTLTIEAANDPNALNKTVHIRLPKNYLTINEIISLWENKIGKTLEKTYVSEEKVLKDIKEASFPNNYLLALYHSQQIKGDAVYEIDTAKDLEASEAYPNVEYTTVDEYLNQFV
What is the function of this protein?
Reduces achiral isoflavones to chiral isoflavanones during the biosynthesis of chiral pterocarpan phytoalexins (PubMed:28394400).  The reduction product is a third isomer, which represents the penultimate intermediate in the synthesis of the phytoalexin (-)-medicarpin, the major phytoalexin in soybean (PubMed:28394400).
What are the official names of this protein?
Isoflavone reductase, GmIFR, 2'-hydroxyisoflavone reductase, NADPH:isoflavone oxidoreductase.
Protein: RLMN_XANP2
Sequence: MMSTPETATEATAPEAAPAPSLGADAPAPLPSLIGLDRDKLGAALDAIGVRGSDRRMRVNQLWHWIYLRGATDFAEMTNVSKHLRADLAAAYSLARPEIVMEQVSQDGTRKWLLRFPADHPGERPHDIETVYIPESDRGTLCVSSQVGCTLNCSFCHTGTQRLVRNLTAAEIVAQVMVARDRLGDYPGRDRATGPGLPTEGDRLVTNIVFMGMGEPLYAYDSVKEAIETLSDGDGLGLGKRRITVSTSGVVPEIERLGAEVGPMLAISLHAVRDKLRDELVPINKKYPIAELMEACRTYPAASNAKRITFEYVMLKGVNDSPADARALVKLLEGVPAKINLIPFNPWPGTQYECSDWETIERFSDIVFRAGYASPVRTPRGRDILAACGQLKSESEKLSARERLALRAMMAQDE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLIK2_MOUSE
Sequence: MLSGVWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASGDSSQRSSHSDTHVQRLTPTTNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVALTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPENPNLSDGTILSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPNVPRNATNLDVSSFQLQYGSYNTETNDKADGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQDFSYGNLEEKKEEPATLAYTISATELLEKQATPREPELLYQNIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKPDHPLLQAKPQSEPDYLEVLEKQTAISQL
What is the function of this protein?
It is involved in synaptogenesis (PubMed:25989451).  Promotes excitatory synapse differentiation (By similarity).  Suppresses neurite outgrowth (PubMed:14550773).
What are the official names of this protein?
SLIT and NTRK-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SLITRK family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein: MTNN_ACTP2
Sequence: MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVGTALLLELTKPDVIINTGSAGGLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAAFLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKIAQIRQDFPNVAAVEMEAAAIAQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RAVA_SALTY
Sequence: MAHPHLLAERISRLSSALEKGLYERSHAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFQRARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTTGYLPEAEIVFLDEIWKAGPAILNTLLTAINERHFRNGAFEEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKANFRSMLVSQQDESDNPVPASLQVSDEEYQQWQKDIGAISLPDPVFELIFTLRQQLDNLPNAPYVSDRRWKKAIRLLQASAFFSGRDAVAPIDLILLKDCLWYDAQSLNLMQQQLEILMTGHAWQQQAMLTRLGGIVQRRLQLQQQQSDKTAFTVIKEGGMFSRRPHYTLPPEASASTLTLLLQKPLKLHDMEVIHITFDRSALELWLTKGGEIRGKLNGIGFAQTLNMEVDNAQHLVVRDISLQGTRLALPGTAEDSMPAEIKQQLETLENDWRQQHTRFSEQQHCLFIHSDWLGRIEASLQDVGEQIRQAKQC
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATY_KLEOX
Sequence: MFIISSKNMLLKAQRLGYAVPAFNIHNLETMQVVVETAAELRSPLILAGTPGTYSYAGTGNVVAIARDLAKIWDLPLAVHLDHHEDLADITRKVQAGIRSVMIDGSHSPFEENVALVKSVVELSHRYDASVEAELGRLGGVEDDLGVDAKDALYTNPEQGREFVARTGIDSLAVVIGTAHGLYAAEPKLGFAALPPISERVDVPLVLHGASKLPDSDIRRAISLGVCKVNVATELKIAFSDALKHYFEENPDANEPRHYMKPAKAAMKDVVRKVIHVCGCEGQL
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol and D-tagatose.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: FLGI_BUCBP
Sequence: MFNQSFLKYMLFGFFLFSFHAHADRIRDLITIQGIRYNQLIGYGLVVGLDGTGDRTNQISYTTHALKNMLFQLGITFPNEQNAKFKNIAAVMVTTKFPNFTHIGQQVDVIVSSVGDATSLQGGTLLMTPLRGTDNKIYAVAQGNIIINDKNSVERFKNILVNNHLNNGMIINGATIEREMHTDFGKNETLNLQLNNEDFTVAQEISKKINMQYPKSAVALNSKIIQVCIPNNNIEQVEMLATIQNINIPIPIQDAKILINAKTGNIITNQTININTCAITHKNISMTIAFNKLKINRLVPNPIIKSDKNNNKTLNDEQIYKNNYNTNNFQYLEKTSNLNTIICALNLFDITTTELISILQSMHDAGCFHAKLEIT
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: PURL_BARQU
Sequence: MNSCNNIAITPELIAQHGLKSDEYQHILTLIGREPTFTELGIFSAMWNEHCSYKSSKKWLKTLPIKGKCVIQGPGENAGVIDIGKGQCVVFKMESHNHPSYIEPYQGAATGMGGILRDVFTMGARPVAAMNALRFGSPNHPRTRHLVAGVVSGIGGYSNAFGVPTVGGEVNFDERYNGNILVNAFVAGIAKTDSIFYSKAQGVGLPVVYLGAKTGRDGVGGAMMASAEFNDSIDEKRPTVQVGDPFIEKCLLEACLELMELKAIVAIQDMGAAGLTSSAVEMGAKGNLGIQLNLDKVPTREENMTAYEIMLSESQERMLMVLKPELKKRAAAIFQKWGLHFSIIGKTTDDLRFRVTHQGEEVVNLPIKELGDEAPVYDRPWIEPTLKPTLKAEEVKKIENFADVLLKLLNSANQSSRRWVYEQYDTLIQGNTLVRPGGDAGVIRVSNNDKRALAFSCDVTPRYCEADPYEGGKQAVVECWRNISTTGATPLAATDNLNFGNPENPKIMGQLVFAIKGISEACRVLDFPIVSGNVSLYNETNGEAILPTPTIAGVGLLDNWSKTVTIGGMQNKDSIVLIGPCGSHLGQSIYARNILNIDAGAPPHIDLQLEKKHGQFVRDVIHRGFVNAAHDISDGGLALALAEMVIKASKGIRIKLSNKSPQHAELFGEDQARYILAVKPHALNSLKELAQVNEISLTELGTVEGNSLNIDSILNLSIDKLTQNYESWFPQFMNEE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CE120_XENTR
Sequence: MGYKSDQLLIVVSILEGRHFPKRSRHMLVIDAKFDGEQLSTDPVPHLEQPQFATELAWELDRKTLHQHRLQRTPIKLQCFALDTLTSAKESVGYVVLDLRAAQEKKQAPKWYSLLSSKYTKFKPEIQLNISLETDNKPAVDTFKAKEAPPRRSKVPGDLAGLEPKSLVPILNEAEGYHQIGPAEYCKDYFVLSVTIAFATQLEQLIPSTLRLPEPQPEFFFYYSLLGNDVTNEPFTDLINPEFEPERASVRIRSSKEVLCMYLSVQPKLQIHLCCGDQSLGSTDIALTGLLNKASVEIEHHPVVVEGAFILTPPNRAKQNLSAVPLEMSPTIGVSIALQKEIGLQSVHHPKEQPQSVAAEEVPTTPLKKSANLKEGARSPPPPKPLMFSDSPPTKDEATESEAESIKSDFQAEPPLSKPLTRSKSPPLSEPPLSGSHCPTPIQGVSAIAKNTSESSSAQKITVPPAAHHFCFTIDLRSIRNVDVGFPVNCILRYSYPFFGSAAPIMTNPPVEVQKNMEVFLPQSYCAFDFATLPHQIQDTFLRLPLLVELWHKDKMTKDLLIGVTKIQLSNVLSSEKTRFLGPHGDQCWRQTFSERITVTAVEGSKNKVAELSYIITLEDYGLVKVREVVVSESSQSTGQEKGSLPAQTLQSTAPLPEPRETLEYKAALELEMWKEMQEDLFVNQLKKKELVHMQALAEEWKRRDKEREALVKKKVAEYTVLEEQLQKALADLEKRERQLANDEMELKKLKAQMQLDCERSIQERQDSIRRVREDCMHQIELERSKAKQLEEDKLRLQQQVELERKLESTTKSKLHYKQQWGRALKELARLKQREQENAMARLKKQQQELEHMRLRYLAAEEKDVVKTERQELEEIRNELNR
What is the function of this protein?
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
What are the official names of this protein?
Centrosomal protein of 120 kDa, Cep120, Coiled-coil domain-containing protein 100.
What is the protein family that this protein belongs to?
Belongs to the CEP120 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: SCIN_STAAS
Sequence: MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
What is the function of this protein?
Involved in countering the first line of host defense mechanisms.  Efficiently inhibits opsonization, phagocytosis and killing of S. aureus by human neutrophils.  Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation.  The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium.  Also prevents C5a-induced neutrophil responses (By similarity).
What are the official names of this protein?
Staphylococcal complement inhibitor, SCIN.
What is the protein family that this protein belongs to?
Belongs to the SCIN family.
What are the subcellular locations of this protein?
Secreted.
Protein: GADA_ALIF1
Sequence: MPLHSKNAVRDDLLDDIYSSADLSLSMPKYKMPEQEHDPRHAYQVIHDELMMDGNSRQNLATFCQTWVEDEVHKLMDECIDKNMIDKDEYPQTAELESRCVHMLADLWNSPDAENTLGCSTTGSSEAAMLGGMALKWAWREKMKKLGKPTDKPNMICGPVQVCWHKFARYWDIELREIPMEGDRLIMTPEEVIKRCDENTIGVVPTLGVTFTCQYEPVKAVHEALDKLQEETGLDIPMHIDAASGGFLAPFCDPDLEWDFRLPRVKSINASGHKFGLSPLGVGWVIWRDASALHEDLIFNVNYLGGNMPTFALNFSRPGGQIVAQYYNFLRLGKEGYRKIHQACYDTAVYLSSEIEKLGMFEIIYDGKGGIPAMSWSLKEGVDPGFNLFDLSDRIRSRGWQIAAYAMPPKREDLVIMRILVRHGFSRDQADLLVADLKHCVEFFAKHPISHGSDELESSGFNHG
What is the function of this protein?
Catalyzes the pyridoxal-dependent decarboxylation of glutamate to produce 4-aminobutanoate.  Has weak activity with aspartate, but cannot complement an E. coli panD deletion mutant.
What are the official names of this protein?
Glutamate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: QUEA_SHEDO
Sequence: MRVADFSFDLPDELIARYPTAQRNASRLLTLDGPTGALADKQFTDLFEMINPGDLMVFNNTRVIPARLFGQKATGGKLEILVERMLDDKRILAHVRSSKSPKVDTLINLDGEHQMKMIARHDALFELELLSELTILEVLEQVGHMPLPPYIDRPDEDADKERYQTVYNKTPGAVAAPTAGLHFDDAMLSALKHKGVNIAFVTLHVGAGTFQPVRVDNVLEHKMHSEWADVPQDVVDLIAQTKAAGNRVIAVGTTSVRSLESAAKACGDKPLATFSGDTDIFIYPGYEFKVVDAMVTNFHLPESTLIMLISAFTGVDEVRYAYQHAIAQKYRFFSYGDAMFLTKKAQ
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.