PharMolix/UniProtQA huggingface dataset:
Protein: RH5_PLAF7
Sequence: MIRIKKKLILTIIYIHLFILNRLSFENAIKKTKNQENNLTLLPIKSTEEEKDDIKNGKDIKKEIDNDKENIKTNNAKDHSTYIKSYLNTNVNDGLKYLFIPSHNSFIKKYSVFNQINDGMLLNEKNDVKNNEDYKNVDYKNVNFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINETYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISEEIDDKSEETDDETEEVEDSIQDTDSNHTPSNKKKNDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKMEYFQTYKKNKPLTQ
What is the function of this protein?
Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:18827878, PubMed:19000690, PubMed:31204103, PubMed:28186186, PubMed:28409866).  By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:28186186).  In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:27374406, PubMed:28409866).  This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866).
What are the official names of this protein?
Reticulocyte-binding protein homolog 5, PfRH5.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, rhoptry lumen. Host cell membrane. Note=In late schizonts, localizes in the rhoptry lumen (PubMed:19000690, PubMed:21909261, PubMed:28409866). During merozoite invasion of host erythrocytes, secreted at the merozoite apical surface where it colocalizes with CyPRA and RIPR at the interface between the merozoite and the erythrocyte (PubMed:19000690, PubMed:21909261, PubMed:25583518, PubMed:27374406).
Protein: TRPD_AERHH
Sequence: MHHHLNTLYQGQSLSRESTRDAFGQVVRGEVDPIVLASLLTALKIKGETPEEIAGAAEALLAEARDFPRPDYEFCDIVGTGGDGLNTINVSTTSALVAAACGLKVAKHGNRSVSSKSGSSDLLDKMGIKLDMSPAQARRCLDELGICFLFAPQYHAGVRHAMPVRQALKTRTLFNVLGPLINPARPTYQLMGVYAPELVRPIAETLLALGLKTGMVVHGAGLDEIAIHGPTQVAQIRDGEIREFLLTPADFGLETYPVSAIQGGEPEENRAITAAILEGRGTPAHNAAIAANVAPLLLMAGKAKDLKSAAAEVLAVLASGKTAELAARLATLSHQEASHQEA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: ELCD_PHANO
Sequence: MSLLQLTASITKAAADLDDATNNAAKASEIESKAKTALLDAAERLVLAYRSPRQWLIDLSFQHCATASLQMIMKYRLHHAVPKQGSRSFAEIAEIITTPDQPGKLPESLVGRLLQHAMSFGLFTPAASGRVAHNDASLLLVTDPDLEAWVYLCSNVAYPAGAQLPKAIEQYGASSEPSETAYSVSIGRRISQFERFREPDGHAEHEMFARAMKGISAGGAYDVGHVVDGGYPWHELPEGTLVVDVGGGPGHVAIALARKYPQLLFEVQDLVETVEFGAKNCPKDLQHRVSFRAQDFFKPQPQRETDSRTIVYFARFILHDWSDKYAGQIVEPLAQAMRPQDRLILNEVVVPEPSVEQRIERKSHDRDLLMLMNLNGRERTLVAFEGLFEVVSPRLRVEKVHKPTTGGELSLITASVDKLTGRKSAGGDIFGANVDEA
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin structurally similar to cercosporin (PubMed:28251756, PubMed:30809363).  The first step of elsinochrome C biosynthesis is performed by the polyketide synthase elcA which catalyzes the formation of nor-toralactone (PubMed:28251756, PubMed:30809363).  The starter unit acyltransferase (SAT) domain of elcA initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain (By similarity).  The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity).  The bifunctional enzyme elcB then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening (PubMed:28251756, PubMed:30809363).  The next step in perylenequinone biosynthesis is an O-methylation at the nascent OH-6 of the elcB product performed by the O-methyltransferase elcD (PubMed:30809363).  The oxidative coupling of the two monomeric naphthol units in perylenequinone biosynthesis is catalyzed by the FAD-dependent monooxygenase elcE and the multicopper oxidase elcG (PubMed:30809363).  ElcG might catalyze the first intermolecular coupling in a regio- and stereo-selective manner via a phenol radical coupling mechanism and the elcE could forge the second C-C bond intramolecularly via a hydride transfer mechanism (PubMed:30809363).  The fasciclin domain-containing protein elcF might also play a role duting this step (Probable).  The last piece of the puzzle in the biosynthesis of elsinochrome C is the additional annulation by enolate coupling to afford the dihydrobenzo(ghi)perylenequinone system, catalyzed by the FAD-dependent monooxygenase elcH (PubMed:30809363).
What are the official names of this protein?
O-methyltransferase elcB, Elsinochrome C biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: Y4BK_SINFN
Sequence: MAMTEKKGGSRKRNERRKNLITGYAGKWEPLFEKKAAARATAARVLSGVSEGVKRAKNTGGTVRVTYVIRSADEEPEIEIEEIAPQKDALDTALAAAKQRGAERVAEILKGPEMLSADEFAEEIGATRETVNRKRKRHEILGLEGAKRGVRFPKWQIGDDGQLLGGLAQLFEALNGHPWAVYRFLLQESDSLGGRTGLEMLRKGMIEHAVGAARSIGRGDFS
What are the official names of this protein?
Uncharacterized protein y4bK.
Protein: CWP26_SOLLC
Sequence: EYIPFIHEWV
What are the official names of this protein?
20 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: XYLA_PHOV8
Sequence: MATKEYFPGIGKIKFEGKESKNPMAFRYYDAEKVINGKKMKDWLKFAMAWWHTLCAEGGDQFGGGTKKFPWNGDADKVQAAKNKMDAGFEFMQKMGIEYYCFHDVDLCEEADTIEEYEANLKEIVAYAKQKQAETGIKLLWGTANVFGHARYMNGAATNPEFDVVARAAVQIKNAIDATIELGGSNYVFWGGREGYMSLLNTDQKREKEHLAQMLTIARDYARSKGFTGTFLIEPKPMEPTKHQYDVDTETVVGFLKTHGLDKDFKVNIEVNHATLAGHTFEHELAVAVDNGMLGSIDANRGDYQNGWDTDQFPIDNYELTQAMMQIIRNGGLGNGGTNFDAKTRRNSTDLEDIFIAHIAGMDAMARALESAAALLNESPYCKMLSDRYASFDSGKGKEFEEGKLTLEDVVAYAKQNGEPKQVSGKQELYEAIVNMYC
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_STRSV
Sequence: MIKQEFLKKMQEKKYFQDHRKVLIAVSGGLDSMTLLQLLIVSQKELAIELAIAHVNHKQRPESDQEEKALVKIAEQLGVKIFTSSFSGNFSENAARQFRYDFFGKVMQEGHYTALVTAHHADDQAETVFMRLLRGARLRHLSGMKAVQPFACGELIRPLLTFHKSDFPDIQHFEDSSNFQNDYLRNRIRNLYLPDLEKENPQFKDSLRYLGKEIEDWQTALSHLTRDLDIENVQVFHQQIPQVQRFLLQNYLENFSGLNLSKQQFEEVLNILQTKANYQHTLKKDYELVKDYQRFEIRKISRKPDLKMDSILLEFENLIEFGYYRFSFGIPLSGENIQKIFVSRETSLTLRFRKEGDSILLNGHHKKLRRLFIDKKVSFEERNSSVVVEQNHQILAILNIAISDLSKALKSDIMSTVLYIQKIDG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_LACLM
Sequence: MPKQKTHRASAKRFKRTGNGGLKRFRAYTSHRFHGKSVKQRRQLRKASMVSKGDFKRIRRMVATMK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ASTB_BURO0
Sequence: MNAQEANFDGLVGPTHNYAGLSFGNVASLNNEKSAANPKAAAKQGLRKMKQLADLGFAQGVLPPQERPSLRLLRELGFSGKDADVIAKAAKQAPELLAAASSASAMWTANAATVSPSADTSDGRVHFTPANLCSKLHRAIEHEATRRTLSTLFADPTHFAVHEALTGTPALGDEGAANHTRFCAEYGKPGIEFFVYGRAEYRRGPEPKRFPARQTFEASRAVAHRHGLAEEATVYAQQDPDVIDAGVFHNDVISVGNRDTLFTHERAFVNKQAIYDTLTAALDARGARLNVIEVPDAAVSVNDAVTSYLFNSQLLSRADGSQVLVVPQECRENANVAAYLDRLAAGNGPIHDVLVFDLRESMKNGGGPACLRLRVVLNDAERAAVTSNVWINDTLFASLDAWIDRHYRDRLAPEDLADPALLDESRTALDELTQILRVGSLYDFQR
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: YHBS_ECO57
Sequence: MLIRVEIPIDAPGIDALLRRSFESDAEAKLVHDLREDGFLTLGLVATDDEGQVIGYVAFSPVDVQGEDLQWVGMAPLAVDEKYRGQGLARQLVYEGLDSLNEFGYAAVVTLGDPALYSRFGFELAAHHDLRCRWPGTESAFQVHRLADDALNGVTGLVEYHEHFNRF
What are the official names of this protein?
Uncharacterized N-acetyltransferase YhbS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: CLPP_RHOP5
Sequence: MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLCAGAKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVKHTGQTYKAIEDALERDKFLTADMARDFGLVDKVIDKRPEEASPAKPV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INUE_ASPNC
Sequence: MARLLKAVTVCALAGIAHAFNYDQPYRGQYHFSPQKNWMNDPNGLLYHNGTYHLFFQYNPGGIEWGNISWGHATSEDLTHWEEQPVALLARGYGSDVTEMYFSGSAVADVNNTSGFGKDGKTPLVAMYTSYYPVAQTLPSGQTVQEDQQSQSIAYSLDDGLTWTTYDAANPVIPNPPQPYQAQYQNFRDPFVFWHDESQKWVVVTSIAELHKLAIYTSDNLKDWKLVSEFGPYNAQGGVWECPGLFKLPLDGGSSTKWVITSGLNPGGPPGTVGSGTQYFVGEFDGTTFTPDADTVYPGNSTANWMDWGPDFYAAAGYNGLSIKDHVHIGWMNNWQYGANIPTYPWRSAMAIPRHLALKTINNKTTLVQQPQEAWSSISSKHPLYSRTYSTFSEGSTNASTTGETFRVDLSFSATSKASTFAIALRASANFTEQTLAGYDFAKQQIFLDRTKSGDVSFDNTFASVYHGPLVPDSTSMVRLSIFVDRSSVEVFGGQGETSLTAQIFPSNDAVHARLVSTGGATEDVRVDVHNITSTWN
What is the function of this protein?
Exo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60.  Splits off terminal fructose units successively from the non-reducing end of the inulin molecule, and also hydrolyze sucrose and raffinose (By similarity).
What are the official names of this protein?
Extracellular exo-inulinase inuE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PQQC_CROS8
Sequence: MTEQRLLTPDEFEAALRAKGAFYHIHHPYHIAMHNGEATREQIQGWVANRFYYQTSIPIKDAAIMANCPHPEVRRQWVQRILDHDGYDGSEGGIEAWLRLGEAVGLSRESLLSEERVLPGVRFAVDAYVNFARRACWEEAACSSLTELFAPQIHQARLDSWPQHYTWIEAEGYDYFRSRLNQARRDVEHGLSLALEYCNTMERQQRMLEILQFKLDILWSMLDAMTMAYTLDRAPYHTVTREAVWHKRRLV
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: AIMP2_BOVIN
Sequence: MPMYQVKPYHEGSGSLRVELPTCMYRLPNVHGRTGSPAPSADHVQEASDPSLQALESHQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPAALSTSTVDLNAMLGQDHGALKDIVINANPASPPLSLLVLHRLLCDHYKVLSSVHTHSAVRSVPANLLQCFGEQTRQQPRHEYQLGFTLIWKDVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKQDAVNLTLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKTPWLVGDELTVADVVLWSVLRQTGGCGGMAPANVQKWMQACENLAPFHTALKLLQ
What is the function of this protein?
Required for assembly and stability of the aminoacyl-tRNA synthase complex.  Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation.  Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.  Functions as a proapoptotic factor.
What are the official names of this protein?
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Protein: PHS_XANC5
Sequence: MTDLIPLEQAHCLPRKGSDHKLGEARLTELLPQVPGWELAEAGMALTRTFRFADYYRTLAFVNALAWIAHREDHHPDLGVHYDRVVVRYSTHDVGGLSENDFICAAKTAQLYDQGITA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ARP6_CANAL
Sequence: MPEQLQKLVIDNGSYTIKAGFNTGDDDGNDTSTPIKVTNAISKTKDGIIHVGNQYLSHTNNFSGIQFRRPFEQNNLTSWETEKPIWDYTLDNLLLQTNDQSQSTSSSSSSSLQKHKRGKVIDPDDIHLILTEQPYQLPQLSTNTDQIIFEEYGFNKYYRCIAPSLVPFSVDTNQINDDFVLVIDSGFNSTWIVPMIYQQIHWPAVKKLPIGGNLLNGLLREMISFRHYDISEDPILINTIKESTCFISSSNYQQDLQHKHDLMCEFVLPDFKLTITGFVKNENSMSSQKLPNDTQVLKLYDERFTVPETYFHPEIIFDNNRTTASSSLLNNAPFKNLTDLIVESIMACPSITQPLLSANICLSGGSTNIPNFKTRLIGELRKELPSNWKVNIFDKQYDINRDELSWYGGINLSNESELLQEISISKKDYFEHGANWCQQQFGFKNV
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Actin-like protein ARP6.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Protein: RS5_NOCSJ
Sequence: MSGAQRGQRGGERRGGRDDRRGQGADKTAYIERVVAINRVAKVVKGGRRFSFTALVVVGDGEGLVGVGYGKAKEVPAAIAKGVEEAKKHFFRVPRIQGTIPHPVQGEKAAGVVLLRPAAPGTGVIAGGPVRAVLECAGIHDVLSKSLGSSNQINIVHATVEALRMLEQPEAVAARRGLPVEEVAPAALLKARVEVPAGVSEEVSS
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RL9_RHOPT
Sequence: MEVILLERVAKLGQMGELVRVKDGFARNFLLPRGKALRATAANREKYEHMKADLEARNIAAKAEATKVAEKIDGQNVVVIRQASEGGQLFGSVSVRDIIASFDGQGVKIDRSQVLLDAPIKTIGKHSIQVAVHPEVEVAVSVTVARSAEEAERINRGEDISTRREDEDAAAEALAAAGEFFDPDAQFGEEQPTEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: KCTD5_BOVIN
Sequence: MAENHCELLPPAPGGLGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPLKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGSEDQAEFLCVVSKELHNSPHGPASEPSEKAKILQERGSRM
What is the function of this protein?
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity).  Does not affect the function of Kv channel Kv2. 1/KCNB1, Kv1. 2/KCNA2, Kv4. 2/KCND2 and Kv3. 4/KCNC4 (By similarity).
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD5.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.
Protein: TTC30_ANOGA
Sequence: MFSQNMIIRDGEYTKTIYTMIKEERFQDAINTLNTIPESSTTRAGLSLLGHCYYQTQDFIEAANCYEHLLNLVPDVQEYRLYYAQSLFQAGLFEEAQKIIATGLDSPELKEKVLQLQSAIAYGNEDYTAAQSLLLQRQDGNGQEASTKNDEGCLLYQANMYEDALQRYVSALQAGGFNPHVAYNAALCHYRRKENSQALNYIAEIVERGIRNHPELGVGAQAETEGGARSVGNPPALAASGLAQAFNLKAAIEYQEGNADGAREALTDLPPRSEPELDPVTLHNMALTDPTGGGAGLRRLAFLLELGPPACPPETFANLLLLCCKHEMYDTAADILAEHTHLTYKYLSPYLYDLLDALITAQSTPEEAEQKLGTLASSIGGRLRALAAKVQECRSATDQNALRMALREYEGALESYLPVAMARAWIPWRMDDFQGAEREFRASAEFCSETPSWRLHAAHVLFMRGDRYKEAAAFYEPIVRQNYDDILSIPASVLANLCVAYIMTSQNEEAEELMRKVERAEERKGNATGQCLHLCIVNLVIGTLYCAKNNYEFGLSRIAHALDGGSGARLCADTWIHVKRCVLGLLTGMAKQTIVLPSIALQETLNFLRACEAYGLTIPSVLTGPLEDSGEQPPTIGLEARKLRALLLRLMEYK
What is the function of this protein?
Required for polyglutamylation of axonemal tubulin in sensory cilia.  Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
What are the official names of this protein?
Tetratricopeptide repeat protein 30 homolog, TPR repeat protein 30 homolog.
What is the protein family that this protein belongs to?
Belongs to the TTC30/dfy-1/fleer family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: AP3M1_PONAB
Sequence: MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.  In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
What are the official names of this protein?
AP-3 complex subunit mu-1, AP-3 adaptor complex mu3A subunit, Adaptor-related protein complex 3 subunit mu-1, Mu-adaptin 3A, Mu3A-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: ATPF_CORGL
Sequence: MANSIYNLAQADALPLESGNSILFPPLYDIVWSLIPFLIILIVFWKLVLPKFQEVLTEREDRIKGGIQRAEAAQAEAKAALEKYNAQLAEARTEAAEIREQARERGKQIEAELKDKANEESNRIIESGSKQLLAQREQVVNELRREMGQNSINLAEHLLGDQLSDNVKRSGTIDRFLADLDTVAPNGK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SMC6_HUMAN
Sequence: MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR
What is the function of this protein?
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.  The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).  Required for recruitment of telomeres to PML nuclear bodies.  SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
What are the official names of this protein?
Structural maintenance of chromosomes protein 6, SMC protein 6, SMC-6, hSMC6.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC6 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Chromosome. Nucleus, PML body. Chromosome, telomere. Note=Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570).
Protein: RFBJ_SALTY
Sequence: MTFLKEYVIVSGASGFIGKHLLEALKKSGISVVAITRDVIKNNSNALANVRWCSWDNIELLVEELSIDSALIGIIHLATEYGHKTSSLINIEDANVIKPLKLLDLAIKYRADIFLNTDSFFAKKDFNYQHMRPYIITKRHFDEIGHYYANMHDISFVNMRLEHVYGPGDGENKFIPYIIDCLNKKQSCVKCTTGEQIRDFIFVDDVVNAYLTILENRKEVPSYTEYQVGTGAGVSLKDFLVYLQNTMMPGSSSIFEFGAIEQRDNEIMFSVANNKNLKAMGWKPNFDYKKGIEELLKRL
What are the official names of this protein?
CDP-abequose synthase, O4 antigen.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: DAND5_MOUSE
Sequence: MFRSQFTTLLGLFSGAWLPTGSGRPGAPATPVQSGTAINQSWTLDPLVPISALGSWEAFLGLQNKQQGTGELQGGGQRVAAGVPLPLAPQEVLQETCKALSFVQVISRPGCTSARVLNHLCFGRCSSFYIPSSDPTPVVFCNSCVPARKRWTSVTLWCGAGQLASPRRVRISTVLVQKCQCRPKL
What is the function of this protein?
Seems to play a role in the correct specification of the left-right axis.  May antagonize NODAL and BMP4 signaling.  Cystine knot-containing proteins play important roles during development, organogenesis, and tissue growth and differentiation.
What are the official names of this protein?
DAN domain family member 5, Cerberus-like protein 2, Cerl-2.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.