PharMolix/UniProtQA huggingface dataset:
Protein: ARNA_ECODH
Sequence: MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDNVNHPLWVERIAQLSPDVIFSFYYRHLIYDEILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: MDTH_KLEP3
Sequence: MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAIADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCSAGAALFIACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEATISLTLLYPIARWSEKRYRLEHRLMAGLLVMTLAMLPIGMTSSLQQLFTLICLFYIGSIIAEPARETLGASLADARARGSYMGFSRLGLAFGGALGYAGGGWLFDAGKAVGQPELPWLMLGAIGFITFLALWWQFSPKRSASGMLEPRT
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YOAH_ECO24
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: NEPI_SALTI
Sequence: MNENIAEKFRADGVARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFSSLFITQIIQATDRRYIVILFAVLLTASCLMVSFANSFTLLLLGRACLGLALGGFWAMSASLTMRLVPARTVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNAAAVMGVLCVIWVVKSLPSLPGEPSHQKQNMFSLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFDVDGLTLVLLSFGIASFVGTSFSSYVLKRSVKLALAGAPLLLALSALTLIVWGSDKTVAAAIAIIWGLAFALVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAVGGYALDNFGLLSPLALSGGLMLLTALVVAAKVRITPMS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine (By similarity).  Required for triggering apoptosis and bacterial survival inside macrophages (PubMed:12228264).
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSCB_PHOLL
Sequence: MDYFTLFGLPARYTVDREQLASCYQELQRQFHPDRFASQPEREKTLALQQAVTINDGYQTLKHPLKRAEYMLSLHGFDLANEQHTMNDNAFLMEQLMLREELECIADKANPEVALADFAARLNGMIKTRSQLMVQQLDEQQWEQAADTVRKLRFLDKLQQQVEQLEERLLDDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: DNAK_MYCSM
Sequence: ARAVGIDLGTTNXVXAV
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y3973_TRIEI
Sequence: MSNIWLYFVPPIAGGIIGYFTNDIAIKMLFRPYRPYYIFRRKLPFTPGLIPANQERLAKRVADTIMGSLLTPSELQNLARRLLQTERMEAAILWLLQMSLDQLKLNTDTKSTKILANILRDLLGQSLPRLLKVWAKREYFLEAQINQIFDQILLEFQLTEIQAAQLSDWLLKVVVPPDVLRKTLIDFLTDQNISIIDEGFREKASGTYWVVANLFGLRNTLTRLRTFCLDERDLTNQRLMELITALAVKERITEWLHSLSMQNLPVSTVRELRNTMQNSVRLYLQENGTDLIQALSLSVAWEHIADLIINRLQASSIMNSSLELVSRELALILERYLERDLENIVALAIPILNIDQVIIDRIKGTSAEELEVAVNVIVKNELQAIVNLGGVLGVVVGSFQTILLVLQR
What are the official names of this protein?
UPF0754 membrane protein Tery_3973.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYA_ACIBY
Sequence: MTSAEIREAFLRYFETQGHTRVASSSLVPANDPTLLFTNAGMNQFKDCFLGLEKRDYVRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKRDALKFAWEFLTSEQWLALPKDKLYVTVYHTDDEAYDIWNKEIGLAPERIIRIGDNKGEKYASDNFWAMGDTGPCGPCSEIFFDHGEHIWGGLPGSPEEDGDRFIEIWNNVFMQFNRTADGVLHPLPAPSVDTGMGLERISAVLQHVNSNYDIDLFQHLLKAAANIIGIEDEGQPSLRVVADHARSCCFLIADGVNPSNEGRGYVLRRIIRRAVRHGNKLGATGTFFYKMLQPLIEVMGQAYPELEARREVIEATLIREEEQFAKTLEQGLKLLEGELAQLKDKTIPGATVFKLYDTYGFPTDLTADIARERGFIIDEAGFEVEMAAQRQRARDAGKFAVDYNNIVKVEGETQFDGYTNTTGQGQIVAIYKDGVQVDEVSEGDEALIVLNQTPFYAESGGQIGDTGIFKNETGIFEVQDTKKSGGAFVHQGIVTVGNLKTSQNVEAIVKADIREATARNHSATHLLHAALRQILGSHVQQKGSLVASDILRFDFANDQPVSFEQLQQVERLVNAEIIANTAVTTELLDIETAKAKGAMMLFGEKYGDEVRVLSMGSVIDEKNFSIELCGGIHVKRTGDIGLFKITSEGGVAAGVRRIEAVTGTKALEVVQKADHDIQHINSLLKAQKDQTVERVQANVELVSALQKQIEQLNQKLANFQAADLIDQVQTIAGRQTLITTVQGVDAKALRNLHDSVKSKLENAVIVLAGVEGDKVSLLASVASQYTANLKAGDIIKHLATELGGKGGGKPDLAQGGAPLNEKFGQVMAALPAWLEQK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_ECOHS
Sequence: MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: BACS1_HALS3
Sequence: MDAVATAYLGGAVALIVGVAFVWLLYRSLDGSPHQSALAPLAIIPVFAGLSYVGMAYDIGTVIVNGNQIVGLRYIDWLVTTPILVGYVGYAAGASRRSIIGVMVADALMIAVGAGAVVTDGTLKWALFGVSSIFHLSLFAYLYVIFPRVVPDVPEQIGLFNLLKNHIGLLWLAYPLVWLFGPAGIGEATAAGVALTYVFLDVLAKVPYVYFFYARRRVFMHSESPPAPEQATVEATAAD
What is the function of this protein?
Involved in the control of phototaxis.  Mediates both photoattractant (in the orange light) and photophobic (in the near UV light) responses.  The signal is then transmitted to the sensory rhodopsin I transducer (HTR-I).
What are the official names of this protein?
Sensory rhodopsin-1, Sensory rhodopsin I, SR-I.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHED_LACP7
Sequence: MGEMIKVGMADMNVCKPPDSITTLGLGSCVGIVLYDPGKKVSGMVHVMLPDSTKIKNNENIAKFADTGIDELVRRLLVLGATRSSLVAKIAGGAQMFAFSSNNDMLRVGERNVEATKEKLNSLRIPILAQDTGLNYGRTIEFNPESSELLIKSVGKPQKKI
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: RRP3_SYNJB
Sequence: MPKFALKALWLENDLAIAVDQVVAKNRSPLTHYFFWPRDDAWEQLKAELESKTWISEVDRIELLNRATELINYWQNGGRNRPISEAQAQFPDILIGGNS
What is the function of this protein?
Probably a ribosomal protein or a ribosome-associated protein.
What are the official names of this protein?
Probable 30S ribosomal protein PSRP-3, Ycf65-like protein.
What is the protein family that this protein belongs to?
Belongs to the chloroplast-specific ribosomal protein cS23 family.
Protein: NADA_CLOPS
Sequence: MDIRDKILKLKKEKGAIILAHYYQIPEIQEIADYVGDSYYLSKIAKDCEENIIVFCGVKFMAESAKILSPEKTVILPVMEAGCVMADMATEEGLAKLKEEHPNAKVVCYINSSTEVKALSDVCCTSSNAENIINNLEEKEIIFLPDRNLGSYIQEKTPDKKFILWNGFCIVHEAIQKEEILRLKREHEGILTVAHPECSKEIRDISDFIGSTSEIINFVNNSSNKKFIIITEEGVLHQLRKNGEEKEFYIPYGKMVCRNMKMTTLKDLYESLLKMENKIEIDEDLRLKAYNSLKNMHKLGG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y838_CHLFF
Sequence: MAGHSKWANTKYRKERADHKRGKIFSRTIKELISAVKMGGPDPKTNARLRVIIQKAKDQNIPSENIERNLKKASSADQKNFEDVTYELYGYGGVGIIVEAMTDNKNRTASDMRIAVNKRGGSLVEPGSVLYNFSRKGACYVPKNSIDEAALLSHVIEVGAEDLDNDDEEHFVVLCDPVDLSSVKEQLVALGVTCTEEKLIYVPLRVVDCDEKDGEANLALIEWLEKIDDVDEVYHNMA
What are the official names of this protein?
Probable transcriptional regulatory protein CF0838.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMI_ECOLI
Sequence: MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECSIYDRSDVAVRKKEGMELTQGPVTGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.  Methylation occurs before assembly of 23S rRNA into 50S subunits.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_BDEBA
Sequence: MSEFSYVHTRGWVEVVVGSMFSGKTEELIRRLRRAEFARLQIQVFKPIIDKRYNEMAVTSHDLTTIDSTPIHDAEEIWNLLKPNTKVVGIDEGQFFGQNLVQIAQDLADRGLRVIIAGLDTDWQGKPFEPMPTLMAVAESVTKQHAVCVVCGAPASRTQRTAGGDGQVLVGTHDAYEARCRQHFKPEVDAPTLDWKLKREMEIS
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_BARBK
Sequence: MTRIVDIVGREVLDSRGNPTVEVDVYLENGVFGRSAVPSGASTGAHEAVELRDGGKRYQGKGVEKAVAAINGEIFKELGGRDARNQLAIDQAMIALDGTSNKERLGANAILGVSLSVAKAAAKSFGLPLYRYIGGTQAHLLPTPMMNIINGGAHADNPIDFQEFMIIPVGAPTFKEAVRYGAEIFHTLKRYLQDAGYNTNVGDEGGFAPNLKSAEQAINLIMESITSCGYKPGEQIAIGLDCASTEFYKNSLYAYEGEGKCRDVKEQVEYLAHLVDSYPIITIEDGMAEDDWAGWKQLTQAIGNKCQLVGDDLFVTNSARLRDGIKMGAANSILIKVNQIGTLSETLDAIETAHKAGYRAIISHRSGETEDSFIADLTVATNCGQIKTGSLARSDRLAKYNQLIRIEEMLGTQARYEGNWHRR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL31_RHIEC
Sequence: MKAGIHPDYHMIKVVMTDGTEYETRSTWGSEGAVMNLEIDSKSHPAWTGGNQQLMDRGGRVSKFNKRFGGLGL
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PKNX2_HUMAN
Sequence: MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQAMMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE
What are the official names of this protein?
Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2.
What is the protein family that this protein belongs to?
Belongs to the TALE/MEIS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GELS_BOVIN
Sequence: MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNDIYQWCGSSSNRFERLKATQVSKGIRDNERSGRARVHVSEEGAEPEAMLEVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALRSEDCFILDHGKDGKIFVWKGRQANTEERKAALKTASDFISKMDYPRQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGPGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGRGQKQIWRIEGSDKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVRSRVVQGKEPAHLMSLFGGKPMIIYRGGTSREGGQTAPASTRLFQVRASSSGATRAVEVMPKAGALNSNDAFVLKTPSAAYLWVGAGASEAEKTGALELLRVLRAQPVQVAEGSEPDSFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDNYWSVDPLDRALAELAA
What is the function of this protein?
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping).  It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity).  Plays a role in ciliogenesis (By similarity).
What are the official names of this protein?
Gelsolin, Actin-depolymerizing factor, ADF, Brevin.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PSAL_PROM4
Sequence: MTEFQDPFLKSGEPVKFDKKYIDSTIRPGDIGIADQWAVKPVSDPFVGNLETPVNSGYFTKAFINNLPFYRSGISPNFRGLEVGAAFGYLLYGPFAMTGPLRNTDFALTAGLLSTIGAVHILTALFVLYTAPGKDPNVQPSDCTVENPPTDLFTRTGWTDFTSGFWLGGCGGAVFAWLLCGTLHLDTIMPIVKGVWAAG
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: GP_SEOUS
Sequence: MWSLLLLAALVGQGFALKNVFDMRIQLPHSVNFGETSVSGYTEFPPLSLQEAEQLVPESSCNMDNHQSLSTINKLTKVIWRKKANQESANQNSFEVVESEVSFKGLCMLKHRMVEESYRNRRSVICYDLACNSTFCKPTVYMIVPIHACNMMKSCLIGLGPYRIQVVYERTYCTTGILTEGKCFVPDKAVVSALKRGMYAIASIETICFFIHQKGNTYKIVTAITSAMGSKCNNTDTKVQGYYICIIGGNSAPVYAPAGEDFRAMEVFSGIITSPHGEDHDLPGEEIATYQISGQIEAKIPHTVSSKNLKLTAFAGIPSYSSTSILAASEDGRFIFSPGLFPNLNQSVCDNNALPLIWRGLIDLTGYYEAVHPCNVFCVLSGPGASCEAFSEGGIFNITSPMCLVSKQNRFRAAEQQISFVCQRVDMDIIVYCNGQKKTILTKTLVIGQCIYTITSLFSLLPGVAHSIAIELCVPGFHGWATAALLITFCFGWVLIPACTLAILLVLKFFANILHTSNQENRFKAILRKIKEEFEKTKGSMVCEICKYECETLKELKAHNLSCVQGECPYCFTHCEPTETAIQAHYKVCQATHRFREDLKKTVTPQNIGPGCYRTLNLFRYKSRCYILTMWTLLLIIESILWAASAAEIPLVPLWTDNAHGVGSVPMHTDLELDFSLPSSSKYTYKRHLTNPVNDQQSVSLHIEIESQGIGAAVHHLGHWYDARLNLKTSFHCYGACTKYQYPWHTAKCHFEKDYEYENSWACNPPDCPGVGTGCTACGLYLDQLKPVGTAFKIISVRYSRKVCVQFGEEHLCKTIDMNDCFVTRHAKICIIGTVSKFSQGDTLLFLGPMEGGGIIFKHWCTSTCHFGDPGDVMGPKDKPFICPEFPGQFRKKCNFATTPVCEYDGNIISGYKKVLATIDSFQSFNTSNIHFTDERIEWRDPDGMLRDHINIVISKDIDFENLAENPCKVGLQAANIEGAWGSGVGFTLTCKVSLTECPTFLTSIKACDMAICYGAESVTLSRGQNTVKITGKGGHSGSSFKCCHGKECSSTGLQASAPHLDKVNGISELENEKVYDDGAPECGITCWFKKSGEWVMGIINGNWVVLIVLCVLLLFSLILLSILCPVRKHKKS
What is the function of this protein?
Forms homotetramers with glycoprotein N at the surface of the virion.  Attaches the virion to host cell receptors including integrin ITGAV/ITGB3.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.  Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion.
What are the official names of this protein?
Envelopment polyprotein, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the hantavirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Multi-pass membrane protein. Host cell surface. Host Golgi apparatus membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host mitochondrion. Note=Interaction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host cell surface. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Budding probably takes place at the host Golgi (Probable). Glycoprotein C cytoplasmic tail is important for efficient Golgi localization (By similarity).
Protein: FOLD_THEM4
Sequence: MIIDVKPLYEDIKVNLLKRIEKLKRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLDYEIFEGNSPKGVLKILAELSRDNNVNGIFVTHPLSQVNEMEIFENLVPSKDIEGRHPYNLGMLAYGEEFFAPCTAEAVVRIMENEIGIPGKNVVIVGRSNTVGKPLAIMLLRRDRSATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDEGIIGDVSKDVANFAKVTPVPGGVGKITTILLMEHLVKSAEKMNF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HIS1_STAAS
Sequence: MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGMADIGIVGSDILDERQYNVNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKANGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAT1_AMABI
Sequence: MSDINATRLPAWLVDCPCVGDDVNRLLTRGESLC
What is the function of this protein?
Major toxin that belongs to the bicyclic heptapeptides called phallotoxins (PubMed:18025465).  Although structurally related to amatoxins, phallotoxins have a different mode of action, which is the stabilization of F-actin (PubMed:18025465).  Phallotoxins are poisonous when administered parenterally, but not orally because of poor absorption (PubMed:18025465).
What are the official names of this protein?
Phallacidin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: ASC9_DIDFA
Sequence: MPYTTIDDLVNSALDYVIIGGGTAGLVLAARLSEKDSVNVGVIEAGLSRLGDPKVDMPTGAALMLGNEDYDWNFKSVPQAASKDRVYHIPRGKMLGGSSAINFMAYGRPCAADIDDWSSKLGLPGWSWNELLPYLKKSQKLESDLPNIKQRDANLFPFLADSQGTDGAIHTSASPWHVPFEDDLLPALDKTSGYARPKDPYSGSHVGFYRSLWAIDRSKKPVRSYSASGFLAPIIDRPNLKVVTNTVACRVLTDSNEDGSMRATGVEVQHDGAIHVLSAQREVILSAGAFQSPQILEQSGIGDPAILHQLKIPCIIGNRNVGNNLQEKLLSAVVYELAPGTMSLDSVLRDPELRKEHQKLYTEAHSGALSGCINLTGFLPYSSLVTSDDIDDTIGDILSLKILSGSPQSPNQNGPFQRWQREAIAARMKSLNSADLQFVCTPANFDTANGYGNLARLSPGSPAGYNACYSLVVSQMYPLSRGSVHSTSSNPLDAPEIDPGFLSHPADVDVIAAGIQFADRVLSSEALRGKVGRRVVPPPSLDLQDRDQVRDFVREHIVTYHHSLGTCAMGQVVDERLRVKGVRSLRVVDASVMPMQVSTAILATVYAVAEKAADMILADHP
What is the function of this protein?
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of the selective antifungal agent ascochitine, an o-quinone methide that plays a possible protective role against other microbial competitors in nature and is considered to be important for pathogenicity of legume-associated Didymella species (PubMed:31554725).  The pathway probably begins with the synthesis of a keto-aldehyde intermediate by the ascochitine non-reducing polyketide synthase pksAC from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (Probable).  Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (Probable).  The HR-PKS (orf7) probably makes a diketide starter unit which is passed to the non-reducing polyketide synthase pksAC for further extension, producing ascochital and ascochitine (Probable).  The aldehyde dehydrogenase (orf1), the 2-oxoglutarate-dependent dioxygenase (orf3) and the dehydrogenase (orf9) are probably involved in subsequent oxidations of methyl groups to the carboxylic acid of the heterocyclic ring (Probable).  The ascochitine gene cluster also includes a gene encoding a short peptide with a cupin domain (orf2) that is often found in secondary metabolite gene clusters and which function has still to be determined (Probable).
What are the official names of this protein?
Dehydrogenase, Ascochitine biosynthesis cluster protein 9.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: PAGP_PECAS
Sequence: MYLKRILITLSLITLPIVPCLSYAAESISNVGINNTGSTANLAPAAADANVSASDKHEESWWQRSKNNLSTTWNAPQSHDIYIPTITWHNRWTYDKEKTDRYNEKPWGAGYGVSRLDKDGDWHGLYIMAFKDSYNKWEPIGGYGYEKRWRPTSDQDFQLGLGFTAGFTMRDNWNYIPIPVLLPLASISYSKLSFQATYIPGTYNNGNVFFAWFRWQI
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.