PharMolix/UniProtQA huggingface dataset:
Protein: GREA_PSYA2
Sequence: MQRYPMTPQGHAALEAELKQLKSIDRPRITASIAEAREHGDLKENAEYHAAREQQGFCEARIRDIEAKLGGAQIIDPATLPKDGRVIFGVSVVIENMDTEEEKQYKIVGDDEADFKAGKISVNSPIARGLIGKSEGDEARIETPKGVVEYEIMKVIYD
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: FADA_ALIF1
Sequence: MKNVVIVDCIRTPMGRSKNGVFRHTRAEDLSAHLMKGLLKRNPSVDPNDIEDIYWGCVQQTLEQGFNIARNSALLAGLPQSIAATTVNRLCGSSMQALHDASRAIMVGDAEICIIGGVEHMGHVPMNHGVDFHSGLSKSVAKASGMMGLTAEMLGKMHGISREQQDAFALASHQKAHKATIEGYFDSEILPMEGHDENGALTLVTHDEVIRPETTLEGLAALRPAFDPANGTVTAGSSSALSDGASAMLVMSEEKANELGLPIRAKVRSMAVSGCDPSIMGYGPVPATKKALKRAGLSLDDIELFELNEAFAAQSLPCIKDLGLLDVMDEKVNLNGGAIALGHPLGCSGSRIATTLINNMERTGAKLGVATMCIGLGQGIATVFERP
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_ECOHS
Sequence: MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAIELDHDKVMNMQAKAEFYSEVLTIVVDGKEIKVKAQDVQRHPYKPKLQHIDFVRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: VM33_CROAD
Sequence: MIQVLLVTILAVFPYQGSSIILGSGNVNDYEVVYPRKVTALPKGAVQPKYEDAMQYELKVNGEPMVLHLEKNKQLFSKDYSETHYSPDGREITTYPLVEDHCYYHGRIENDADSTASISACNGLKGHFKLQGEIYLIEPLKLRDSEAHAVFKYENVEKEDEAPKMCGVTQNWESYEPIKKASQLVVTAEQQRYLNPYRYVELVIVADHGMFTKYNRNLTEVKTWVYEIVNTLNEIYRYLYIRVALVGLEIWSDGDLSNVTLSSGNTLDSFGEWRKRDLLRRKRHDNAQLLTAIDFSGNTIGRASIANMCDPKYSTGIVQDHSPINLLVAVTMAHEMGHNLGLHHDGKSCTCGDYICIMNATLSHQHSKYFSNCSYNQYWDYINTYTPKCILNEPLRTDIISPPVCGNELLEAGEECDCGSPRNCQYQCCDAATCKLHSWVECESGVCCEQCKFRTAGTECRARRSECDIAESCTGQSADCPTDDFHKNGQPCLNNFGYCYNGNCPIMYHQCYALFGSNVYEAEDSCFESNQKGDDYGYCRKENGEKIPCAPEDVKCGRLYCNDNSPGQNDPCKIFPSNEDEHKEMVLPGTKCADGKFCTNGHCVDVATAY
What is the function of this protein?
Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like 3a, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_IDILO
Sequence: MNVILLDKIANLGSLGDQVSVKSGYARNFLFPQGKAVPATKSNVDLFEQRRAEYEAKLADQLAAAQARAEKVNALDAVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVKKSEVLMPHGTLREVGEFDIELHLHADVFANITLKVVPAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ULAG_SHIB3
Sequence: MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQAAPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNLEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDP_ECO8A
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: YXJF_BACSU
Sequence: MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAASKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTDTFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVIGLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVPQKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ
What are the official names of this protein?
Uncharacterized oxidoreductase YxjF.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RSMA_GEOSW
Sequence: MNKDIATPGRTREILEKYGFSFKKSLGQNFLIDTNILRKIVDFAELSDETGAIEIGPGIGALTEQLARRAKKVVAFEIDQRLLPILEDTLSPYGNIRIIHQDVLKADIHRVISEEFTGMTDIMVVANLPYYVTTPIIMKLLTDRLPIRGMVVMLQKEVADRLAAKPGTKDYGSLSIAIQYYTEAETVMTVPRTVFIPQPNVDSAVIRLIKRKQPPVKVEDEAFFFQVVRASFAQRRKTILNNLVNNLPNGKAMKEQIERVLTETDIDPRRRGETLTMEEFAALSNALQHVL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GD_HHV1F
Sequence: MGGAAARLGAVILFVVIVGLHGVRGKYALADASLKMADPNRFRGKDLPVLDQLTDPPGVRRVYHIQAGLPDPFQPPSLPITVYYAVLERACRSVLLNAPSEAPQIVRGASEDVRKQPYNLTIAWFRMGGNCAIPITVMEYTECSYNKSLGACPIRTQPRWNYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRAKGSCKYALPLRIPPSACLSPQAYQQGVTVDSIGMLPRFIPENQRTVAVYSLKIAGWHGPKAPYTSTLLPPELSETPNATQPELAPEDPEDSALLEDPVGTVAPQIPPNWHIPSIQDAATPYHPPATPNNMGLIAGAVGGSLLAALVICGIVYWMRRRTQKAPKRIRLPHIREDDQPSSHQPLFY
What is the function of this protein?
Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate.  May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
What are the official names of this protein?
Envelope glycoprotein D, gD.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein D family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where final envelopment occurs.
Protein: VATA_CHLTB
Sequence: MVATSKQTTQGYVVEAYGNLLRVHVDGHVRQGEVAYVSVDNTWLKAEIIEVVGDEVKIQVFEETQGISRGALVTFSGHLLEAELGPGLLQGIFDGLQNRLEILADTSLFLRRGEYVNAICRETVWAYTQKASVGSVLSRGDVLGTVKEGRFDHKIMVPFSCFEEVTITWVISSGNYTVDTVVAKGRTSTGEELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCTPGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLKDPHTGQSLMHRTCIICNTSSMPVAARESSIYLGITIAEYYRQMGLHILLLADSTSRWAQALREISGRLEEIPGEEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSPAGGNFEEPVTQATLSVVGAFCGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGESVKQASRFLEEGAEIGKRIEVVGEEGISMEDMEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMNHIFNSRFCFDCPDNARSFFLELQSKIKTLNGQKFLSEEYQKGLEVIYKLLESKMVQTA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: YIDD_BRUME
Sequence: MGSCGGKHTGKGAPKPYSRNFTDPWRKTPGRLFGTALIRFYQITLSSLIGNSCRHLPTCSEYAYEAIARHGLWRGGWMGFFRVVRCGPFGTHGFDPVPRELSPDLKWYMPWRYWRCSASRIGK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYH_STRZJ
Sequence: MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIFEHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQKPSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETISMAAYFLKEIGIQGVKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVAVENAPSILDFLDEESQTHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIEGNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIAVLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFAAKTLITLGESEVESGQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPD_AZOVI
Sequence: MKYVDEFRDGATARQLAARIAAEADPKRQYRLMEFCGGHTHAIFRYGIPDLLPANVRLIHGPGCPVCVMPIGRLDMAIELARRPGVILCTYGDMLRVPASGRVSLLKARAEGAAVRMLYSPIEALKLAQDNPDRDVVFFAIGFETTTPPTALVIEQAQRLGLKNFSVFCNHVLTPAAMHAILATPEARAGTLQLDGFIGPAHVSTVIGSDAYAPFPRQYGTPLVIAGFEPLDLLQALLMLVRQLNEGRAEVENQFTRAVTAGGNLKAKALTGRIFELRESFEWRGLGALPNSALRIREAFAEFDAERRFALEARSGLENKACECPAILRGAKSPRDCKLFGNPCSPDNPLGSCMVSSEGACAAWYAYGRQRQAVVAVAR
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
What are the official names of this protein?
Hydrogenase maturation factor HypD.
What is the protein family that this protein belongs to?
Belongs to the HypD family.
Protein: RL27_HELPS
Sequence: MAHKKGQGSTQNNRDSAGRRLGVKKFGSEFVRAGNIIVRQRGTKMHPGNNVGMGKDHTLYALIDGVVKFEHKDRNRKKVSVVSQNFGE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: TX101_HUMAN
Sequence: MGTPRIQHLLILLVLGASLLTSGLELYCQKGLSMTVEADPANMFNWTTEEVETCDKGALCQETILIIKAGTETAILATKGCIPEGEEAITIVQHSSPPGLIVTSYSNYCEDSFCNDKDSLSQFWEFSETTASTVSTTLHCPTCVALGTCFSAPSLPCPNGTTRCYQGKLEITGGGIESSVEVKGCTAMIGCRLMSGILAVGPMFVREACPHQLLTQPRKTENGATCLPIPVWGLQLLLPLLLPSFIHFS
What is the function of this protein?
Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity).  May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).
What are the official names of this protein?
Testis-expressed protein 101, Cell surface receptor NYD-SP8, Scleroderma-associated autoantigen, Spermatogenesis-related gene protein.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Cytoplasmic vesicle. Note=Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa.
Protein: FRMA_ECOK1
Sequence: MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFELARRFGATDCINPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY
What is the function of this protein?
Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent.
What are the official names of this protein?
S-(hydroxymethyl)glutathione dehydrogenase, Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RASF4_RAT
Sequence: MKEDCSPSSHVPISDSKFILKSELLSLLKTYNCYHEGRSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQDDRERVHLPSATWVPERLSYLQKDASPQDSKVPAEEPSTQPANKGEVSRDGSGPLQEEEEEVPQLMRTKSDASCIIQRRCKSRAPGEAQKIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTQQVLTLLLNKFRVEDGPSEFALYTVHESGEQTKLKDCEYPLISRILHGPCEKIVKIFLMEADLSEEVPHDVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMQQRLEQLVEAK
What is the function of this protein?
Potential tumor suppressor.  May act as a KRAS effector protein.  May promote apoptosis and cell cycle arrest (By similarity).
What are the official names of this protein?
Ras association domain-containing protein 4.
Protein: TI11A_ORYSI
Sequence: MASTDPMTRRFAVACGVLSQYVKANSSQPSTAAPVAQGVSGLMAAAAAAAAAPVVQEPGCEVDGGGQQFTIFYAGKVVVIDRCTPAMAAELMRFASAAQGGGGAPEAPPALVDMPIARKASLKRFLAKRKATPASARSSYVVRAAAAEEEQPPAKKAKADVERREDWLALGSLGHMHSR
What is the function of this protein?
Repressor of jasmonate responses (By similarity).  Involved in tolerance to salt and dehydration stresses (By similarity).
What are the official names of this protein?
Protein TIFY 11a.
What is the protein family that this protein belongs to?
Belongs to the TIFY/JAZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HNRPL_RAT
Sequence: MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
What is the function of this protein?
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion.  Exhibits a binding preference for CA-rich elements.  Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts.  Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.  As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein L, hnRNP L.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules.
Protein: WNT51_EPTST
Sequence: SGSCSLKTCWMQLSPFREVGNRLKQKYDQAAAVRLARRRRLEPVNQRFSPPTKMDLVYLETSPDYCMRNDTTGAAGTAGRQCERGSAGTGGCELMCCGRGYDSFRATSTERCHCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-5(I).
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TYSY_SHISS
Sequence: MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_PSEU2
Sequence: MQISVNEFLTPRHIDVQVVSPTRAKITLEPLERGFGHTLGNALRRILLSSMPGCAVVEAEIDGVLHEYSAIEGVQEDVIEILLNLKGLAIKLHGRDEVTLTLSKKGSGVVTAADIQLDHDVEIVNPDHVIANLASNGVLNMKLTVARGRGYEPADSRQSDEDESRSIGRLQLDSSFSPVRRIAYVVENARVEQRTNLDKLVIDLETNGTLDPEEAIRRAATILQQQLAAFVDLKGDSEPVVIEQEDEIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLDNWPPASLKKDDKATA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: INS_AOTTR
Sequence: MALWMHLLPLLALLALWGPEPAPAFVNQHLCGPHLVEALYLVCGERGFFYAPKTRREAEDLQVGQVELGGGSITGSLPPLEGPMQKRGVVDQCCTSICSLYQLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR9_CLOB6
Sequence: MIKRALISVFDKTGILDLAKFLESRDVEIISTGGTYKHLKENGVKVIDIEEVTGFPEMLDGRVKTLNPLIHGGILAIRDNEEHMKVIEEKGIKPIDMVVVNLYPFFNKVEEDLSFDEKVEFIDIGGPTMIRAAAKNFKDVVVLTDTKDYENVINEIKENNQVNIKTKKKLAGKVFNLMSAYDAAISNFLLEEEYPEYLTLSYKKNMDLRYGENPHQTAAYYTSTVGKYPMKNFKKLNGKELSYNNIKDMDIAWKTVCEFKEVACCALKHNTPCGVAIGDTIQEVYTKAYECDPISIFGGIVAFNRKVDKETAENLIKIFLEIVVAPDFDEDALEVLKTKKNLRVIKCEEKSTQDKDMTKVDGGILVQQSDNKLLEDTKVVTEKSPTEKEMNDLIFGMKVVKYVKSNAIVVIKDGMAKGIGGGQVNRIWAAKEALDRAGDGVVLASDAFFPFGDVAEEAAKWGIKAIIQPGGSIRDEESIKVCNEKGISMVFTGVRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: REPA1_BUCCC
Sequence: MFKRKKYVDNPYPKFVQPKNHKKRPAFIRYAMRCAAQTDVARNELYYTNPLKNPITGCVLHRKRRLNEHRARALRAVVQAMLYYFNIASMLVMASVEKLSDVCGLSTYSSAGNKSITRASRLITQFMEPMGLISCEKIWDKILGMYIPKIIYLKPLFFMLFDISKIRLKRVRIKQLEWINSQLKKKGEYPITLLEIEKQAKEKHIHSALLFRKSKYIIKKQKNKAKKFLELDEKYAKSYILNNLVKKYSTKELCKLGLTKLKRKVNCEYFRLKKLAQLPVV
What is the function of this protein?
This protein is essential for plasmid replication; it is involved in copy control functions.
What are the official names of this protein?
Probable replication-associated protein repA1.
What is the protein family that this protein belongs to?
Belongs to the IncFII RepA family.
Protein: CYSD_GEOSM
Sequence: MTTQLTHLQQLEAESIHIIREVVAEFDNPVMLYSIGKDSAVMLHLARKAFYPAPPPFPLLHVDTTWKFRDMIEFRGRMAKESGMELLVHVNEEGVKRGVSPFTHGSALYTDVMKTEGLKQALDRYKFDAAFGGARRDEEKSRAKERIFSFRSANHRWDPKNQRPELWSLYNTRIKPGESIRVFPLSNWTELDIWQYIHLEEIPIVPLYYAAVRPVVERDGMLIMVDDDRLELKPGEKVEHKSVRFRTLGCYPLTGAVESEADTLPEIIQEMLLTRTSERQGRLIDHDQAGSMEKKKQEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: Y542_CHLPN
Sequence: MTIRILAEGLAFRYGSKGPNIIHDVSFSVYDGDFIGIIGPNGGGKSTLTMLILGLLTPTFGSLKTFPSHSAGKQTHSMIGWVPQHFSYDPCFPISVKDVVLSGRLSQLSWHGKYKKKDFEAVDHALDLVGLSDHHHHCFAHLSGGQIQRVLLARALASYPEILILDEPTTNIDPDNQQRILSILKKLNRTCTILMVTHDLHHTTNYFNKVFYMNKTLTSLADTSTLTDQFCCHPYKNQEFSCSPH
What is the function of this protein?
Part of an ATP-driven transport system CPn0541/CPn0542/CPn0543 for a metal.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Probable metal transport system ATP-binding protein CPn_0542/CP_0210/CPj0542/CpB0563.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HIS2_BIFLS
Sequence: MKTFESLFAELSEKAQTRPEGSLTVDELDKGTHFIGKKIIEEAGETWMAAEYEGADRTAEEMSQLLYHVQVMMIKHGLTLEDVYKHL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR4K1_HUMAN
Sequence: MAHTNESMVSEFVLLGLSNSWGLQLFFFAIFSIVYVTSVLGNVLIIVIISFDSHLNSPMYFLLSNLSFIDICQSNFATPKMLVDFFIERKTISFEGCMAQIFVLHSFVGSEMMLLVAMAYDRFIAICKPLHYSTIMNRRLCVIFVSISWAVGVLHSVSHLAFTVDLPFCGPNEVDSFFCDLPLVIELACMDTYEMEIMTLTNSGLISLSCFLALIISYTIILIGVRCRSSSGSSKALSTLTAHITVVILFFGPCIYFYIWPFSRLPVDKFLSVFYTVCTPLLNPIIYSLRNEDVKAAMWKLRNRHVNSWKN
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4K1, Olfactory receptor OR14-19.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.