PharMolix/UniProtQA huggingface dataset:
Protein: PLSX_SPHAL
Sequence: MALTPRIAIDAMGGDVGVRVMLAGAAMARHKHDGLRFILVGDEERIKAALDNHPNLRAASDIIHTDGVVSGEDKPSQALRKAKSTSMGLAIDAVKRGDAGGAVSAGNTGALMAMAKLALRTMPGIDRPALAALLPTLGDNDVVMLDLGANTECDATNLTQFAVMGAAYARTAMGLERPRVALLNIGTEELKGTDEIRDAAALLRGAEGLPMQFAGFIEGDKLSRGDVDVIVHDGFSGNIALKTIEGTARFVTDLLRRAFTSSTRSKIGFLISRPATELLRHHLDPNNHNGAVFLGLNGVVLKSHGSADAKGVANCVHLCAELIEKDITRQVTEDLANFRRGDAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: YM02_PARTE
Sequence: MLWELLNLLDLRYRFLQQLDLYFLNLNYTLSKLCSKQTEATAPYSKLYYKNLGLAFFYFFFFLLAFLALFIFFFRGFQGTLFFNSVLLSNKGLYFVLFYVAALALLFVFRHHVLKQFFFNNSLDFLIALVFLTLFSTLIFFSNNLFAFFFTLELVAVTNFYFISSAREFFFFEKSQGGASSLKAQKKKTFFNVRFF
What are the official names of this protein?
Uncharacterized mitochondrial protein ORF2.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RUVB_XANOR
Sequence: MDQRIIASSSTREDDAADASIRPKRLADYLGQQPVREQMEIYIQAAKARGEAMDHVLIFGPPGLGKTTLSHVIANELGVSLRVTSGPVIEKAGDLAALLTNLQPHDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGDGPAARSIKIDLPPFTLIGATTRAGLLTAPLRDRFGIVQRLEFYSPQELTRIVIRSAAILGIDCTPEGAAEIARRARGTPRIANRLLRRVRDYAQVKAAGHIDLPVAQAAMQMLKVDPEGFDELDRRMLRTIVEHFDGGPVGVESLAASLSEERGTLEDVIEPYLIQQGFLIRTARGRMVTTKAYLHLGLKPPRDRAPGIGEPGDLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: UVRC_SHEFN
Sequence: MPSGFNAKSFLKNVTSAPGVYRMYDKHQQVIYVGKAKDLKKRLSSYFRVNIANVKTQALVSHIDHIDVTVTHSETDALLLENDYIKQYMPKYNVLLRDDKSYPYILLSGHKHPRLAYHRGPKREKGHYFGPYPNGGAVRESLHLIQKLFPIRQCDDLYYKSRSRPCLQYQLDRCSAPCVGIVSDDEYSEQVKLAGLFLRGKDKQVISQLVAKMETAAIDMEYERAAQYRDQITALRRVAEQQEVSNHKGDMDVIGVDYASGIACFHLLFIRDGKIFGSRSYYPSVPAETEIEEVLSSFLGQFYLNADIQRTIPKEVILSHHFDGITELQASIEHALDKKFELKTQVRGDRANFLRLAMTNASNAVATKLSHKNTVEQRFQLLEEALELNEPIKRMECFDISHTMGESTVASCVVFNREGPHKADYRRYNITGITGGDDYAAMEQAISRRFDKIDNNGKVPDLVFIDGGIGQLRVAQTIVDEKCVNIDHPPLLICVTKGEGRKAGLETFTVGGSEQTFEVASDSPAFHLMLHIRDESHRFAITGHRNKRQKTRNTSTLESIAGVGPKRRKALLQHLGGIQEVKGASVAELTKVPGISLEMAQTIHDALRGG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_LEPBL
Sequence: MSQVKRTPLYETHRALGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGEPKIVLDFLELVTCNSVASLSDFQVQYNAILNENGGLVDDVTIYKFSAEKYMICSNASNYETVTAHLLKYLPASGVKVSDQSPNWHQIALQGPKANEIFSKFLGRELDSIKYYHFALLDYQGEEIIVSRTGYTGEDGFEIYSSIPFGLKLWSGLSEFGKPQGLLPCGLGARDTLRIEAKYPLYGHELNNQWTPIESGIGWIVKEKKNPYFSSGKILSQKKNGTEFKIVAFALTEAGVPRENFRVLDFQGNEIGKTTSGTFSPSLKKGIGLASIRTEKIKDGEPIQIEIREQPKQAIITTKPFIPGSIRKN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: NCAP_CVTMI
Sequence: MASGKATGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKAKKLNSPPPKFEGSGVPDNENLKPGQQHGYWRRQARFKPSKGGRKPVPDAWYFYYTGTGPAADLNWGDSQDGIVWVAAKGADVKSRSNQGTRDPDKFDQYPLRFSDGGPDGNFRWDFIPLNRGRSGRSTAASSAASTRAPSREGSRGRRSGSEDDLIARAAKIIQDQQRKGSRITKAKADEMAHRRYCKRTIPPGYKVDQVFGPRTKGKEGNFGDDKMNEEGITDGRVTAMLNLVPSSHACLFGSRVTPKLQPDGLHLKFEFTTVVPRDDPQFDNYVKICDQCIDGVGTRPKDDEPKPKSRSSSRPATRTSSPAPRQQRSKKEKKPKKQDDEVDKALTSAEERTNAQLEFDDEPKVINWGDSALGENEL
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the gammacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: PSBC_OENGL
Sequence: MKTLYSLRRFYPVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGLGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSILFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRALVWSGEAYLSYSLAALSVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDFEPALSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MLXPL_RAT
Sequence: MARALADLSVNLQVPRVVPSPDSDSDTDLEDPSPRRSAGGLHRSQVIHSGHFMVSSPHSDSLTRRRDQEGPVGLADFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSSREGDFLAPKQVEGGWPPPERWCEQLFSSVVPVLLGGSEEEPGGRQLLDLDCFLSDISDTLFTMTQPSPSSLQLPSEDAYVGNADMIQPDLTPLQPSLDDFMEISDFFTNYRPPQTPTSSNFPEPPSFGPMADSLFSGGILGPEMPSPASASSSSGMTPLSGNTRLQARNSCSGPLDPSTFPSSEFLLPEDPKTKMPPAPVPTPLLPYPGPVKVHGLEPCTPSPFPTMAPPPALLSEEPLFSARFPFTTVPPAPGVSTLPAPTTFVPTPQPGPGPGPVPFPVDHLPHGYLEPVFGPHFTVPQGVQPRCKPCSPPPGGRKASPPTLTSATASPTATATARDNNPCLTQLLRAAKPEQVLEPSTVPSTLLRPPESPDAVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRPSGDLNSIQPPGALSVHLSPPQTVLSRGRVDNNKMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASLHSLRQTSLAWLDQYCSLPALRPTVLNSLRQLSTSTSILTDPSLVPEQATRAVTEGPLGRPL
What is the function of this protein?
Transcriptional repressor.  Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
What are the official names of this protein?
Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPMA_ECOBW
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPLKRYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: NU1C_JASNU
Sequence: MIIYNTTELQAIHSFSRLEFLKEVYGSIWVLIPILTLVLGITLGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKENLFPSRGDTRLFTIGPSIAVISILLSYSVIPFGYRLILGDLSIGVFLWIAVSSLAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSFSTVDIVEAQSKYGFWGWNLWRQPIGFIVFLISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWNLSIPYLFVPELFERGKVFETIICIFITLAKTYLFLFISIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSFQLLSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KA156_TITDI
Sequence: MKAFYGMLVIFILCSTCYISVDSQIDTNVKCSGSSKCVKICIDRYNTRGAKCINGRCTCYP
What is the function of this protein?
Irreversibly blocks the A-type voltage-gated potassium channels in rat cerebellum granular cells (190 nM induce 50% inhibitory effect) (IC(50)=190 nM) (PubMed:15369825, PubMed:18280256).  Also weakly inhibits Kv1. 2/KCNA2 and Kv1. 3/KCNA3 (PubMed:29483648).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 15.6, Discrepin.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_SODGM
Sequence: MTIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFFDSLVDFMISGPILVQVLEGEDAVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSDSAESAAREIAYFFADGEVCTRIR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APX3_ARATH
Sequence: MAAPIVDAEYLKEITKARRELRSLIANKNCAPIMLRLAWHDAGTYDAQSKTGGPNGSIRNEEEHTHGANSGLKIALDLCEGVKAKHPKITYADLYQLAGVVAVEVTGGPDIVFVPGRKDSNVCPKEGRLPDAKQGFQHLRDVFYRMGLSDKDIVALSGGHTLGRAHPERSGFDGPWTQEPLKFDNSYFVELLKGESEGLLKLPTDKTLLEDPEFRRLVELYAKDEDAFFRDYAESHKKLSELGFNPNSSAGKAVADSTILAQSAFGVAVAAAVVAFGYFYEIRKRMK
What is the function of this protein?
Plays a key role in hydrogen peroxide removal.
What are the official names of this protein?
L-ascorbate peroxidase 3, AtAPx03.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein. Glyoxysome membrane; Single-pass membrane protein.
Protein: HDAC7_MOUSE
Sequence: MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLHQQQRSAEPMRLSMDPPMPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGGTLPSRLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASPLLAPLQPRQDRLKPHVQLIKPAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMANDGLEHRESGRGPPEGRGSISLQQHQQVPPWEQQHLAGRLSQGSPGDSVLIPLAQVGHRPLSRTQSSPAAPVSLLSPEPTCQTQVLNSSETPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEESWKQKPNLSAIRSLEAVVRVHRKYWGCMQRLASCPDSWLPRVPGADAEVEAVTALASLSVGILAEDRPSERLVEEEEPMNL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C.  During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.  Positively regulates the transcriptional repressor activity of FOXP3 (By similarity).  Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity).  In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
What are the official names of this protein?
Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Protein: PUR5_PSESM
Sequence: MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAAQVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVAAGDALLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKETGAVKAMAHITGGGLLDNIPRVLPEGAQAVVDVASWQRPAVFDWLQQQGNVEENEMHRVLNCGVGMVICVAQEHVDAALNVLREAGEQPWVIGQIATAAEGAAQVELKNLKAH
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG1_HALMA
Sequence: MLKTVLMPSPSKCSLMAKRDQDWSPNQLRLDILDQNARDADPRGTGFDYAEEFQELDLDAVKADLEELMTSSQDWWPADYGHYGPLFIRMAWHSAGTYRTTDGRGGASGGRQRFAPLNSWPDNANLDKARRLLWPIKKKYGRKLSWADLIVLAGNHAIESMGLKTFGWAGGREDAFEPDEAVDWGPEDEMEAHQSERRTDDGELKEPLGAAVMGLIYVDPEGPNGNPDPLASAENIRESFGRMAMNDEETAALIAGGHTFGKVHGADDPEENLGDVPEDAPIEQMGLGWENDYGSGKAGDTITSGIEGPWTQAPIEWDNGYIDNLLDYEWEPEKGPGGAWQWTPTDEALANTVPDAHDPSEKQTPMMLTTDIALKRDPDYREVMERFQENPMEFGINFARAWYKLIHRDMGPPERFLGPDAPDEEMIWQDPVPDVDHDLIGDEEVAELKTDILETDLTVSQLVKTAWASASTYRDSDKRGGANGARIRLEPQKNWEVNEPAQLETVLATLEEIQAEFNSARTDDTRVSLADLIVLGGNAAVEQAAADAGYDVTVPFEPGRTDATPEQTDVDSFEALKPRADGFRNYARDDVDVPAEELLVDRADLLDLTPEEMTVLVGGLRSLGATYQDSDLGVFTDEPGTLTNDFFEVVLGMDTEWEPVSESKDVFEGYDRETGEQTWAASRVDLIFGSHSRLRAIAEVYGADGAEAELVDDFVDAWHKVMRLDRFDLE
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase 1, CP 1, Peroxidase/catalase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: NFU1_DROGR
Sequence: MSKLISYAAKSPLRNIRLGATQIICQHASTDCMHMAASASASSSARKTYSTLAVDLTKQQMLLRKPLETLALQITKRSMFIQTQDTPNPDSLKFLPGVEVLGKGNTYDFPSATAAHCSPLAKLLFRVEGVRAVFFGSDFITISKEENGEWGLIKPEVFAVIMDFFASGLPILHEARPNADTEILEDDDETVMMIKELLDTRIRPTVQEDGGDIVFISYEKGVVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVESVEQVFDEVDKVANSEFERFEKSLKQKDSANPPVSIGGTQN
What is the function of this protein?
Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
What are the official names of this protein?
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AIRE_MOUSE
Sequence: MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALLSWLLTRDSGAILDFWRILFKDYNLERYSRLHSILDGFPKDVDLNQSRKGRKPLAGPKAAVLPPRPPTKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKKPDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGILIQQVFESGRSKKCIQVGGEFYTPNKFEDPSGNLKNKARSGSSLKPVVRAKGAQVTIPGRDEQKVGQQCGVPPLPSLPSEPQVNQKNEDECAVCHDGGELICCDGCPRAFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRSASEKTRGPSRELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSAGNEGRPGPAPSARCSVCGDGTEVLRCAHCAAAFHWRCHFPTAAARPGTNLRCKSCSADSTPTPGTPGEAVPTSGPRPAPGLAKVGDDSASHDPVLHRDDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS
What is the function of this protein?
Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable).  Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-.  ATTGGTTA-3' combined with a 5'-TTATTA-3' box.  Binds to nucleosomes (By similarity).  Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'.  Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression.  Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity).  Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306).  Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913).  Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453).  In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482).  In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells.  Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652).
What are the official names of this protein?
Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog, APECED protein homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern.
Protein: MVD1_DANRE
Sequence: MSENILQDLEMVTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNGKEQDISHPRLQSCLLEIRRLAQRRKNTGDPASDVSNKVHICSVNNFPTAAGLASSAAGYACLVYTLSQLFNVEGELSGVARQGSGSACRSLYGGFVQWKLGEQSDGKDSIAEQVASELYWPELRVLILVVSAEQKSVGSTSGMHTSVETSHLLKYRADAVVPGRMEEMIRAIRLRDFPKFGELTMKDSNQFHAICLDTYPPIFYLNNISHQIISLVHRYNQYYGETRVAYTFDAGPNAVIYSLQDYLPEFVEVVRHFFPPEVNEEEFFKGLPVCPADLSEEMIRDINMKPTPNGIRYMISTKAGPGPRVVEDPNLHLLGADGLPKKSAV
What is the function of this protein?
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
What are the official names of this protein?
Diphosphomevalonate decarboxylase, Mevalonate (diphospho)decarboxylase, MDDase, Mevalonate pyrophosphate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the diphosphomevalonate decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_RHIL3
Sequence: MAETAASRTGSVSRKTNETSISVSVNLDGTGKSTISTGVGFFDHMLDQLSRHSLIDMEIDAKGDLHIDDHHTVEDTGIAIGQAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPFLVWNVAFSAPKIGTFDTELVREFFHALAQNAGITLHILNHYGANNHHIAETCFKAVARALRTATEIDPRQAGRVPSTKGTLV
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BURP2_ORYSJ
Sequence: MARSLAALLLLLVAAAGASHAASPAEMYWKIALPTSPMPGAIRDLISPASSAASASKDKEDTVGSVFFLEKDLFPGSKMTLHFTRATAGAALLPRGRADSVPFASEKLPEILSQLSIPAGSPTADAMRSTLAVCEAARIASETAPKHKHYCATSLESMVELVASSLGTRDVHAVSTEVVNRAGPTPRQAYRVEAVRPVPVPGGDMVACHRMPYAYAVFGVHGIKGAAYTVTLAGADGTMAEAVAACHGDVDGHGVAVAEAYKRLGVAPGKVAVCHFLPQDDMLWVRN
What are the official names of this protein?
BURP domain-containing protein 2, OsBURP02.