PharMolix/UniProtQA huggingface dataset:
Protein: B4GT4_RAT
Sequence: MGCNPPYLLSYRLRLLLLFTLCLTVLGWATSNYFVGAIQVIPRAKNFMATLHKVMYLGNEETLGHGAAMKKAELANCPSVSPNLRGQNKLVFKPDLTLEEVQAKNPKVSRGRYRPEECKALQRVAVLIPHRNREKHLIYLLEHLHPFLQRQQLDYGIYVIHQTGSKKFNRAKLLNVGYLEALKEENWDCFIFHDVDLVPENDFNLYTCGDQPKHLVVGRNSTGYRLRYSKYFGGVTALSREQFFKVNGFSNNYWGWGGEDDDLRLRVELHKMKISRPKPDVGKYTMIFHTRDKGNEVNGSRMKLLQQMSRVWKTDGLSSCSYRLLSVEHNPLYANITVDFWTAA
What is the function of this protein?
Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids.  Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans.  Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer.  Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex).  May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration.  In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide.
What are the official names of this protein?
Beta-1,4-galactosyltransferase 4, Beta-1,4-GalTase 4, Beta4Gal-T4, b4Gal-T4, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Lactotriaosylceramide beta-1,4-galactosyltransferase, N-acetyllactosamine synthase, Nal synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
Protein: BMNL1_BOMVA
Sequence: MNFKYIVAVSILIASAYARSEENDIQSLSQRDVLEEESLREIRGIGGALLSAAKVGLKGLAKGLAEHFANGKRTAEEREVMKRLEAAMRDLDSFEHPEEASEKETRGFNQEEKEKRIIGPVLGLVGSALGGLLKKIG
What is the function of this protein?
Bombinin H has antibacterial and hemolytic activity.
What are the official names of this protein?
Bombinin-like peptides 1.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: REG1_PYRHO
Sequence: MAGIDEIDEVIVRELRKNSRITLTELGRKVGLTASAVKNRIEKLEKLGVIKGYSAVVDPSFFGEFLTAVIEIELIDPDSPDLPRILTPILKMRNISDVYKKTGEFHLVIRGTFRDVESLNTFLKDLKRNYLRNLARRTRISIVLENFKEAGVTLK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator PH0045.
Protein: WDR44_RAT
Sequence: MMPLKMCTWGGSYPVGSPGKVGLLSFKETKNTGNKAGNESPVQELRQDVSKKIIECIIEESQKVLQLEDDSLDSKGKGLSDQATASHSVAGTEFSNIPGLLAIQHELQQGSRKADSQNAAEETELETQKCFPSDNNCEKSEKTEDETNNLTEVSSADQLDASKLETEILNKEAVEVKEGDVVNPASSDALSTKDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRPPPPSRPAPPPRKKKSDLEFEALKTPDLDVPKDNIASDSLLTTNMASESTVRDSLPSLDLASATSGDKIVTAQENGKAPDVQTVAGEVMGPQRPRSNSGRELTDEEILASVMIKNLDTGEEIPLSLAEEKLPTGINPLTPLTLHIMRRTKEYVSNDATQSDDEEKLQSQQTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLASAGQDNIVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKSDTDMGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAIFAPNPSLMLSLDVQSEKLEGIDKYEDAEVLDNTSTGIVKTDNTEVLLSADFTGAQCFYVKNSFLYP
What is the function of this protein?
Downstream effector for RAB11.  May be involved in vesicle recycling.
What are the official names of this protein?
WD repeat-containing protein 44, Rabphilin-11.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia.
Protein: YD83A_YEAST
Sequence: MKNHPRKVKFRVSSAKFICIYWFFCLYYKDGPILYTIYTTFLSHRYSYSTFIILRNTVAFLSFMYKHYYTHISYLTFYKSPKTFY
What are the official names of this protein?
Putative uncharacterized protein YDR183C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RLMF_ECO24
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_BRUO2
Sequence: MPEKEGGRFHASVLTLYPEMFPGPLGISLAGKALAEGKWQLDTVQIRDFAEGRHRMVDDTPSGGGAGMVMKADVVARALDSVDDGRPMLLMTPRGKPLTQERVRALADGAGAIILCGRFEGVDERVIEGRNLEEISIGDYILSGGETAAIVLLDAVVRLLPGVMGNRESGETESFETGLLEHPHYTRPQEWEGRAIPDILTSGNHGAIDKWRLEQAERITRERRPDLWEAYCKNRRKIGGQ
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH2_KLUMA
Sequence: MSIPTTQKGVIFYENGGQLYYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVAMGDNVKGWKIGDLAGIKWLNGSCMNCEECELSNESNCPDADLSGYTHDGSFQQYATADAVQAAHIPAGTDLAQVAPILCAGVTVYKALKTAEMKAGDWVAISGAAGGLGSLAVQYAKAMGFRVLGIDGGEGKEELFKSLGGEVFIDFTKSKDIVGEVIKATNGGAHGVINVSVSEKAIESSIEYCRSNGTVVLVGLPKDAKCKSDVFNQVVKSIHIVGSYVGNRADTREALDFFCRGLVNAPIKVVGLSTLPEIYEKMEQGKVLGRYVVDTSK
What are the official names of this protein?
Alcohol dehydrogenase 2, Alcohol dehydrogenase II.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WAGC_DROME
Sequence: MQNLKIQEEVNSLMRLGQHFDDQLKLASVELGDFSDDDLALLDKCAQYYSLLHIHDINLNYLRDFYCAKKRECIENRQTTVQQRVELQRILSSIEEATRDVVMLERFNAAAEERLIPDIVVMQRNAQQLATKQALLDRQKTLKIPKDFSIESVIEKVDSLEQR
What is the function of this protein?
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:19289792).  The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:19289792).  wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation (PubMed:19289792).  It is required for microtubule assembly near spindle poles in oocytes (PubMed:23785300).  It is also required for acentrosomal microtubule nucleation and meiotic spindle formation during male meiosis (PubMed:24829288).  wac binds to microtubules in vitro (PubMed:19289792).
What are the official names of this protein?
Augmin complex subunit wac, wee Augmin component.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Enriched at spindle poles during meiosis in oocytes.
Protein: CLPS_PSE14
Sequence: MHAFSKIRLTFNQDSPQSHEDDAAGIAVQDAKPTLQAPPMYKVVLFNDDYTPMDFVVEVLEVFFNLNRELATKVMLAVHTEGRAVCGLFTRDIAETKAMQVNQYARESQHPLLCEIEKDG
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RS6_PARUW
Sequence: MSQKVQNLYEGMYVISATLSDDARHKALDRIQTGITGHGGEIKKLHEQGRRRLAYEIDGHREGYYYLVYFTAPSSAISDLWQEYHLNEDLIRFITLRTDEVMEKIEFKTLDEQQ
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: TOLB_CHLTB
Sequence: MKGSVVFLRSLLCLLCLLPSTLHCEDLEIHVRSESSLLPIAVSLLSSPKDSRQASYLASLRDLFARDLALGDLLAPTKELAPQTIFIEASYPELIFSLKKEGKGSQKIFSLELSGDPSKDHQAIHEAADRIHFLLTRVPGISSGKIIFSLCATNSSTELKQGELWSVDYDGQHLYPLTNEHSLSVTPTWMHISHIPAYMYVSYKLGVPKIFLNTLNQPAGKKILAMQGNQFMPTFSPKTKLLAFISDRDGNPDLFVQSFSLATGAIGTPKKLLNEAFGTQGNPSFSPDGTRLVFVSNKDGTPRIYQMQISPEQHSPRLLTKKYRNSSCPTWSPDGKKIAFCSVIKGVRQICVYDLASGRDEQLTTSTEHKESPSWAADSNHLVYSAGSSNTSELFLLSLITKKSRKIVIGSGEKRFPCWGAFPSQHIKKTS
What are the official names of this protein?
Protein TolB homolog.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TVP23_ASPFU
Sequence: MDQPLQAQQGELNWRLSAHPITLLFFLGFRTSALLMYLFGVLFIKNFVLVFILTLLLLSADFYYLKNIAGRRLVGLRWWNEVNTATGDSHWVFESSDPATRTISATDKRFFWLSLYVTPALWIGLAVLAIVRLSSVIWLSLVAIALVLTITNTVAFSRCDRFSQASTYANRAFGGNIVNNLAGGLLGRLFK
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein tvp23.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: TVB77_HUMAN
Sequence: MGTSLLCWVVLGFLGTDHTGAGVSQSPRYKVTKRGQDVTLRCDPISSHATLYWYQQALGQGPEFLTYFNYEAQPDKSGLPSDRFSAERPEGSISTLTIQRTEQRDSAMYRCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 7-7.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RS20_BURP6
Sequence: MANSAQARKRARQAAKANSHNSALRSKFRTAIKAVRKAIDAGDQAKAAELFKAATKTIDTIADKKIVHKNKAARHKSRLSAAVKGLQAQAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SECB_SHEAM
Sequence: MAEVANNEQQAPQFNIQRIYTKDVSFETPNSPAVFQKEWNPEVKLDLDTRSTKLADDIFEVVLSVTVTAKNGDETAFLCEVQQAGIFHIGGLTEPQLAHSLGAYCPNILFPYARESVASMVSRGTFPQLNLAPVNFDALFAQYVQQRAAAAQPTEEANA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_XANC5
Sequence: MNTTVSNQTPRIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: OSW5_YEAST
Sequence: MVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
What is the function of this protein?
Involved in spore wall assembly.
What are the official names of this protein?
Outer spore wall protein 5.
What is the protein family that this protein belongs to?
Belongs to the OSW5 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RECU_STRA5
Sequence: MVNYPHQLIRKTTVTKSKKKKIDFANRGMSFEAAINATNDYYLSHELAVIHKKPTPVQIVKVDYPKRSRAKIVEAYFRQASTTDYSGVYKGYYIDFEAKETRQKTAMPMKNFHAHQIEHMANVLQQKGICFVLLHFSTLKETYLLPANELISFYQIDKGNKSMPIDYIRKNGFFVKESAFPQVPYLDIIEEKLLGGDYN
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2C1_MANES
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSFIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATTKYLLMGGASSSILVHAFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSLAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMIVGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNGGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIVEIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YIF4_YEAST
Sequence: MAPKAFFVCLPWVLPRHALIVRQAGNPYHFLAYTNPRAPGKLQDSHCPVFFMGIIIITIITVTLAIIIINIIFLTLFDDGMCFYCSLLTFSFVSFNFDHFDHFDL
What are the official names of this protein?
Uncharacterized membrane protein YIL054W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PURA_PROM0
Sequence: MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDDKVLKLHLIPSGILYKNTSCLIGSGTVVDPKILLKEIDMLIDNGIDISGLKISSTSHVTMPYHRILDEAMEADRGSNKIGTTGRGIGPTYADKSQRNGIRIRDLLNKERLSDVIEIPLREKNGLLEKIYGIKPLKLEDIVEEYLDYGERLSKHVVDCTRTIHAASKNKKNILFEGAQGTLLDLDHGTYPFVTSSNPISGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELQGSINDQLCDRGSEFGTTTGRRRRCGWFDGVIGKYAVSVNGLDCLAVTKLDVLDELDEIQVCIAYDLDGEKIDYFPTNSDELKKCKPIFKKLKGWQCSTADCRKLSDLPENAMNYLRFLAELMEVPIAIVSLGANRDQTIVIEDPIHGPKRALLR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_FRATW
Sequence: MSYIKKLRARLDSGEISAVELTKEYLAKIKEQDKRINSVITLCEAEALKEAEDADAIISAGKQGLLTGIPILHKDLFCTKGIRTTAASKMLDNFVAPYDSTVTKNCKDQGMVTLGKLNMDEFAMGSTNEYSYYGAVSNPWDLERVPGGSSGGSAAAVAAGFAPISTGSDTGGSVRQPASFCGLTAMKPSYGSTSRFGMVAFASSFDQAGIFGHYAEDVAIMLDAIAGECEFDSTCVGVKQNHFTQDLEKDISGKVIGVDESLIKDLPAQIQEAVSKTLDNFKKLGAEIKSVKVPDLKEALSTYYIITPAEAAANLARYDGIRYGYRNPEARDLDELYRKSRTDGFGAEVKRRIMIGNYVLASSQYDSYYNKAQQLRKVMTDQINQIFTQVDAIFMPASPSEAFKKGDKLDPVSAYLSDIYTIPANISGLPAIAFPIGFANNLPVGGQLMAKAFNDNILTQMVVQYQKHYGIEEFILQQARI
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RF1_ENTFA
Sequence: MYDQLQSIEDRYEELGELLSDPAVISDTKRFMELSKEEANTRETVEVYRRYKQVVEGISDAEELLSENLDAEMAEMAKEELSDLKKEKEVLEDRIKILLLPKDPNDDKNIIMEIRGAAGGDEAALFAGDLFNMYQKYAEAQGWKAEVLEANVTGIGGYKEVIMMISGDNVFSKLKYESGAHRVQRVPSTESQGRIHTSTATVVVMPEAEEVEIELADKDIRVDIYHASGAGGQHVNKTASAVRLTHLPTGIVVAMQDERSQLKNREKAMKVLRARVYDQIQQEAQSEYDANRKSAVGTGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILAGKLDEIIDALVLYDQTSKLEEMQNG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_MYCBT
Sequence: MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHFRELTIGQVKAALAAEGITVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_HV1SC
Sequence: MRVKGSGRNYQHLWRWGTMLLGILMICSAAEQLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNIWATHACVPTDPNPQEVVLGNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNLRNDTSTNATNTTSSNRGKMEGGEMTNCSFNITTSIRSKVQKEYALFYKLDVVPIDNTSYTLINCNTSVITQACPKVSFEPIPIHYCARWFAILNCNNKKFNGTGPCTNVSTVQCTHGIRPVVSTHLLLNGSLAEEEVVLRSENFTDNAKTIIVQLKEAVEINCTRPNNNTTRSIHIGPGRAFYATGDIIGDIRQAHCNISRAKWNNTLKQIVIKLRDQFENKTIIFNRSSGGDPEIVMHSFNCGGEFFYCNSTQLFSSTWNGTEGSNNTGGNDTITLPCRIKEIINMWQEVGKAMYAPPIKGQVKCSSNITGLLLTRDGGNSKNGSKNENTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGTIGAMFLGFLGAAGSTMGATSMTLTVQARLLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNTSWSNKSLDKIWGNMTWMEWEREIDNYTSLIYTLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFTVLSIVNRVRQGYSPLSFQTRLPSQRGPDRPEGIEEEGGERDRDRSGRLVDGFLAIIWVDXRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELRNSAVSFVNATAIAVAEGTDRVIELLQRAFRAILHIPTRIRQGLERALQ
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.