PharMolix/UniProtQA huggingface dataset:
Protein: F16A1_NITHX
Sequence: MSRELTLQERLDGEAGPDPLRQAVKKAVAALAQAAIDISDLTCRGALAGITGEAQGRNTDGDVQKDLDVRADQIIRDALGALPIAVLASEEMAELDILNPGAPISVAFDPLDGSSNINTNISVGTIFSIMPTPPDASAAFTQPGSAQLAAGFVVYGPQTSLILTLGQGVDIFTLDRVERVFKLTGSMMQIPADATEFAINTSNRRHWDLPVRAYIDECLMGADGPSGKNFNMRWIGSLVAEAFRILVRGGIFLYPGDARDGYEDGRLRLVYEAHPMAFIIEQAGGGASTGRKRILDIVPGSLHQRVPLIMGSIKNVRRLEDMHTGPNVALEANAPLFGHRGLFRV
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_STRGC
Sequence: MSKILLGFMGAGKTTVGRLLDPNFHDMDELIVNQIGMSINDFFAQEGEEAFRKIETATLESLLANQAKIISPGGGIVVNPHNRDLLEKNPYNIYLRVDFDTLYKRIENDLAMQRPLYLNNTREEFKKIFEARLPIYEKIATHIIDVAGKTPEEIAEIIRCL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPTA_METAC
Sequence: MEHCTFNLPDVQASKPSIAINLTRVGVTNMKKLVEIKRKDKRPIVLISTFDVFVDLPSDRKGANLSRNFEAVDEVLEKVLSTPVYEIEQLCSDIAHNLLGRHEYANQAEVRMKSEYMIRRASPSTGIKCQEVVNIFAEASAVRGVGDKDYFDVKKLIGAEVVGMTACPCAQEIMRDKAANELAELGVDRDTIIRFLEKVPMATHNQRGRGIISIKVAHDFDVSLESIIRIIERSMSSSVYEVLKRSDEKVVVETAHMNPKFVEDCVRAMADNIVKEFPNLPDNAVITIKQINEESIHRHNAFAERVALMGELRSEINQ
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: GPI7_CANAL
Sequence: MSGSLNSRWVVQVSLTIINIIGFLVFLRGFFPSKVVLPGFNSFQDSTKSPFSDQYGNPQFNKFILMVVDAMRSDFCFSDRSNFSFLHQLINQGRALPFTAFSNPPTVTLPRLKGITTGGTPNFLDAILNVADDQDDSQGLHNQDSWVHQFRHSNNKTINFFGDDTWLKLFQDQFTEFEGTNSFFVSDFTEVDNNVTRHLDDQLSSNKWDGLILHYLGLDHIGHKGGPESPYMKPKQIEMDKILQRLYTYVTKNDDTLIVLMGDHGMNEIGNHGGSSPGETSAALSFISPKFNHKGESPLPYNSDYSYHHKISQIDLVPTLAALLNFPIPKNSLGVIAKEILEIWPENQRIKILLENCAQIMNLYEAKYGPSGKVWSQWENLQAKQHPIADYYEFLQDIQSEMASSATNYGYKDIYAGALILVITALAVIVVFNRYFLTASNMNISSVMFYELFVVLYSLHFHGSSLIEEEHQIWYFFTTATLLFLAITFFDTFKSLQNFISFGVLFACIRFMRSWNNSGQKYSSQYNIAYYLSHSNPNLMWGLIILTYFVLTLCIYIQGSLVPTFAFSFGKRLPDVKDPGGLISFIVVFVATSVSFSFKLLQYYIDGNTIPKWLNRFLLWIIESHHIDLSSATLEDNELKFQLQSVSIQLSKFTTIILLLLVISRVIIGKIRKIRYGTITDITNIMTIYLIHQTRHENIPIFLALMFAKFALSKLIYRKTNRIDQYILTVTMTVLCLQNLTFFCMGNTNSLATVDLSNAYNGVKAYNVFLVGLLTFVSNFAGPIFWSLSGLQLLYEPSLLNFNGPATTDLLHYTGLKKSILLVKSLISLFFYTVSAVNLVGSCINLRFHLFIWTVFSPKLLFFGSWILFVNVLIDLILAVIVLLF
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the GPI second mannose (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 2, Glycosylphosphatidylinositol-anchor biosynthesis protein 7.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FOLD_STAA3
Sequence: MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SEPF_AGARV
Sequence: MSFIDKILDKMSLNSEDDEEFDNEDYYLDDEEEEELPRNPFRRKKEAVEEETAIKSTRRDTTPKEKPVKTTSKITPISKSSRKQVASDMEVCVIKPSSIEDEIEITDTLLNGRTVVINMEGLNVDVAQRIIDFTSGSAYALHGNLQKISNFIFIATPHGVDISGDIQSLMDSFDLPGSSY
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: OBG_FRASN
Sequence: MPTFVDRVVLHAAAGDGGHGCCSIHREKFKPLGGPDGGNGGRGGNVLLRVDSGVTTLLDFHFHPHQRAGGGRPGQGSNRHGADGDDLVLSVPDGTVVLSPDGEQIVDLVGAGSTYVLAHGGRGGRGNASLASARRKAPGFAELGEPGEQLDAVLELKSVADVALVGFPSAGKSSLVSVLSAARPKIADYPFTTLVPNLGVVQAGDHRPFTVADVPGLIPGASQGRGLGLEFLRHIERCSLIVHVLDCATLEPGRDPLTDLDVIEAELAAYTTDLSDRPRLVVLNKVDVPDAAELAELVTPDLQARGLAVHQISTASRHGVRGLALALAELVASLRAAVPSPAATRIVLRPRAVDEPDFTVRAEGDGFVVGGTKPLRWVRQTDFSNEEAIGYLADRLARLGVEKELAKRGAFPGVAVTIGAVTFDWEPTLSGREALLAAGGGDGDGYGEAGYGAVDTAVTIATVGGSGGTRAGARGGAVVSDLPLGPRGTDLRLRTSKRLTRAQRTALSDSADDFDDGAGFSDSAAFGDSGGSGGDADGGRG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL37_CENSY
Sequence: MVKGTTSMGGFTRKHVHIRCRRCGKNSYHKRHHRCSSCGFPDAKIRKYSWVKWYT
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L37e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: CYA1_MYCTU
Sequence: MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV
What are the official names of this protein?
Adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRDI_SALPB
Sequence: MSALVYFSSSSENTHRFMQRLGLPATRIPLNERERIQVDEPYILVVPSYGGGGMAGAVPRQVIRFLNDEHNRARIRGVIASGNRNFGDAWGCAGDVIAQKCGVPWLYRFELMGTQRDIDNVRKGVNEFWQQLSRSA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: RL36_VIBPA
Sequence: MKVRASVKKICRNCKVIKRNGVVRVICSEPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RNH_ECO81
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLEA1_NIDPL
Sequence: MFTLKKTLLLLFFLGTISISLCKQERDADEDDGRKMTEEEVKRSIITMTKEAKLPQLWKQIACRLYNTC
What is the function of this protein?
Antimicrobial peptide.  Has activity against the Gram-positive bacterium S. aureus ATCC2592 (MIC=15 ug/ml), the Gram-negative bacteria E. coli ATCC25922 (MIC=60 ug/ml), B. dysenteriae (MIC=120 ug/ml), H. pylori NTCT11637 (MIC=30 ug/ml), and the fungus C. albicans ATCC2002 (MIC=30 ug/ml).  Has little hemolytic activity on rabbit red blood cells.
What are the official names of this protein?
Pleurain-A1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_VEREI
Sequence: MQHQRNPQLNGQGELIHLLSIEGLPRDIVTHILDTAANFVSVNDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVFNLDITRSSASKGESLLDTIANLSAMAADLFVVRHSESGAPYLIARHVAPHVHVINAGDGRHAHPTQGLLDLYTIRHYKKDFSQLTVAIVGDMLHSRVARSDIHGLITLGCAEVRAVGPRTLVPADMAQMGVRVCHQLQEGIEGADVIIMLRLQNERMSGALLSSSQEYFKSFGLTPEKLQLAKPDAIVMHPGPINRGVEIDSAVVDGRQSVILPQVGFGIAVRMAVMSIVAGNEACGH
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: GATA_ACIB5
Sequence: MTDLHRLSIRELAEGLSQAKFSSRELTEHYLKRIAKIDPQVKSYVTVTPEQALREADAADAALKAGNATALTGIPLAHKDIFCTKGIKTTAGSKMLDNFISPYDATVVEKTKAAGLVTLGKVNMDEFAMGSTSESSYVGATSNPWALDHVPGGSSGGSAAAVAADLAPFATGTDTGGSIRQPASFCGLTGLKPTYGRVSRFGIIAYASSLDQAGPMARSAEDCAYLMNVIAGHDAKDSTSVKKELDDYVANLNNTSVKGLRIGIPKQYFNVAGLDADVKARVEESLKKLEEMGAALVEIDLNMTEAYVPTYYLIAPAEASSNLSRYDGVRYGYRCENPADLMDLYKRSRSEGFGPEVQRRILIGTYALSAGYYDAYYVKAQKVRRLIQQDFLKAFENVDVIAAPAAPTTAYKIGASLDPVEMYLGDIYTIAVNLAGLPAINAPVGFDKDNLPVGLQLIGNYWSESQLLSIVHQYQQNTDWHTKRAAIAEENA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: AIN1_SCHPO
Sequence: MQANQWQSVQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNPRMRVHRLENVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFTIADINEEGLTAKEGLLLWCQRKTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDLLDYNKLDKKNHRANMQLAFDIAQKSIGIPRLIEVEDVCDVDRPDERSIMTYVAEYFHAFSTLDKVETAARRVERFTEVLMSTHDMKIDYESRMKRLLGSIARMQEYWHTVQFENNYTDVKSHSNNFAKFKATEKREWVKEKIDLESLLGTIQTNLKTYQLRKYEPPAGLKIVDLERQWKDFLSEEANQSKLINTHMREIKESMRIAFADRANSFSKMLSTISNEITNLQGDWRDQLDHVEFLQEHLGPLEVELASVKVLYDNCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKYLENELLEREKRTLSKQELDGITKVFRHFEKKKSNMLNEVEFYAALASLGLVYDTEEGTALFHRAANSEEGVTYERFTEIVMEELEDRDSARQVLYAFCDVADGKSYVTSDDLLRSQVRPNIVKFLECNMNKHSEGLDYLTWIKQLLAEDKEIV
What is the function of this protein?
Binds to actin and is involved in actin-ring formation and organization.  Plays a role in cytokinesis and is involved in septation.
What are the official names of this protein?
Alpha-actinin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Localizes to the medial ring in an F-actin-dependent manner.
Protein: HEM3_HELAH
Sequence: MGKLVIGSRGSELALWQANYIKERLKKECFIESEIQIVKTTGDKILDAPLNKIGGKGLFTKELEELLLKGTIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSTKFPDLMSLPKGAKVGTTSLRRSMQLKCKRKDLDTESLRGNVQTRLKKLESGEFDAIILAEAGLCRLNIQGAKYRKAFSVEEMIPSMGQGALGVEMLKSHKHFTALQKLNDEESAFCCHLEREFIKGLNGGCQIPVGVHASLMGEKVKIQAILGLPNGEEVIAKEKQGDKNKAFDSVQELLEAFLQSGAREILEKVQLF
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: SH3L3_HUMAN
Sequence: MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA
What is the function of this protein?
Could act as a modulator of glutaredoxin biological activity (Probable).  May play a role in cytoskeleton organization (PubMed:34380438).
What are the official names of this protein?
SH3 domain-binding glutamic acid-rich-like protein 3, SH3 domain-binding protein 1, SH3BP-1, TNF inhibitory protein B1, TIP-B1.
What is the protein family that this protein belongs to?
Belongs to the SH3BGR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LSM1_SCHPO
Sequence: MNQATQIIPFTTSGSLVDYVDRKVIVVLRDGKKLIGILRSFDQFANLMLQYTIERIYVDDMYGDIDRGVYIVRGENVVLLGELDLDKEYDAVKQLRRMPAEELYPLAKLHEEEKKKNIREKGKYLHSVGFSVDGGHDDLY
What is the function of this protein?
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step.  The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm1.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body.
Protein: EF2_CANAW
Sequence: MVAFTIEQIRGLMDKVTNVRNMSVIAHVDHGKSTLSDSLVQKAGIISAAKAGDARFMDTRKDEQERGITIKSTAISLYASMTDEDVKDIKQKTDGNSFLVNLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQTTKEDLYQTFARTVESVNVIISTYCDPVLGDVQVYPQKGTVAFASGLHGWAFTVRQFANKYSKKFGVDKEKMMERLWGDSYFNPKTKKWTNKDKDADGKPLERAFNMFILDPIFRLFAAIMNFKKDEIPVLLEKLEIQLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQTYRAETLYEGPSDDPFCTAIRNCDPNADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYQVGKKEDLFLKSIQRTVLMMGRSVEQIDDCPAGNIIGLVGIDQFLLKSGTITTNEAAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLENDHAGVPLRISPPVVSYRETVEGESSMVALSKSPNKHNRIYVKAQPIDEEVSLDIENGVINPRDDFKARARILADKHGWDVVDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIKDSVVAAFQWATKEGPIFGENCRSVRVNILDVTLHADAIHRGGGQIIPTMRRVTYASMLLAEPAIQEPVFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQLIFDHWQVMSGDVTDENSKPGAIVKEKRVRAGLKPEVPEYTEYYDKL
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIHI_PECAS
Sequence: MNRPVKGVADKAEKSKVKRKTREELEREARERKRDKKHRGHSAGSRTQEKASTDQNSGQRKVADPRIGSKKPVQLGVLDSAIVKPKPKSKPSEPVEKVVAAKPTMSPEEELAMLENDTRLDALLDRLDSGETLSAKDQSWVDETLDRIDILMEELGIELGDDDEEEQQEDMLQLLKRNNPKDAL
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: ASSY_XYLFT
Sequence: MSNKNIVLAFSGGLDTSFCIPYLKEQGYAVHTVFADTGGVDEDERDFIEKRAAELGVASHLTVDGGPAIWDGFVKQLVWAGEAYQGQYPLLVSDRYLIVDAVLQRADALGTCAVAHGCTGMGNDQVRFDLAIKAQGDYTIIAPIREIQKEHTQTRLYEQKYLEERGFGVRAKQKNYTINENLLGITLSGGEIDKWEAPGEGARGWCAPRSAWPTDPLTVAIKFVEGEAVAVDGKPLSGPQILMKLNKLFASYGVGRGIYTGDTVIGLKGRIVYEAPGLTALLTAHRALEDAVLTKQQNRFKPHIARKWVELVYEGFFHDPLKTDLETFLKSSQANVNGEIVLETRGGRVDAVAVRSPHILTSKGVTYAQTADWGIEEAEGFIKLFGMSSTLYAHVNRSLRS
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I73A5
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: NCAP_MEASM
Sequence: MATLLRSLALFKRNKDKPPITSGSGGAIRGIKHIIIVPIPGDSSITTRSRLLDRLVRLIGNPDVSGPKLTGALIGILSLFVESPGQLIQRITDDPDVSIRLLEVVQSDQSQSGLTFASRGTNMEDEADQYFSHDDPISSDQSRFGWFGNKEISDIEVQDPEGFNMILGTILAQIWVLLAKAVTAPDTAADSELRRWIKYTQQRRVVGEFRLERKWLDVVRNRIAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPALGLHEFAGELSTLESLMNLYQQMGETAPYMVILENSIQNKFSAGSYPLLWSYAMGVGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSTLASELGITAEDARLVSEIAMHTTEDKISRAVGPRQAQVSFLHGDQSENELPRLGGKEDRRVKQSRGEARESYRETGPSRASDARAAHLPTGTPLDIDTATESSQDPQDSRRSADALLRLQAMAGISEEQGSDTDTPIVYNDRNLLD
What is the function of this protein?
Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases.  The nucleocapsid (NC) has a helical structure with either 12. 35 or 11. 64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases.  N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response.  Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NP, Protein N.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: FXL12_HUMAN
Sequence: MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.  Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
What are the official names of this protein?
F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12.
Protein: FTHS_ARATH
Sequence: MSSSTRKLEVVSPVPADIDIANSVEPLHISEIAKDLNINPLHYDLYGKYKAKVLLSAFDELQGQEDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAYLDKKVVTCLRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITASNNLLAAAIDTRIFHETSQSDKALFNRLCPPNKEGKRSFSDIMFRRLTKLGISKTSPEELTPEEIKKFARLDIDPASITWRRVMDVNDRFLRKITIGQGPEEKGMTRETGFDISVASEIMAVLALTTSLGDMRERLGKMVIGNSKAGDPITADDLGVGGALTVLMKDAINPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGSDIGTEKFMNIKCRYSGLTPQCAIVVATVRALKMHGGGPDVVAGRPLDRAYVSENVSLVEAGCVNLAKHISNTKAYGVNVIVAVNMFATDTEAELNAVRKFSMDAGAFDAVVCSHHAHSGKGAVDLGIAVEKACQNITQPLRFLYPLDIGIKDKIEAIAKSYGASGVEYSDQAEKQIEMYTQQGFSNLPICMSKTQYSFSHDASKKGAPSGFVLPIRDVRGSIGAGFIYPLVGTMSTMPGLPTRPCFYEIDIDTETGKVRGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, 10-formyletrahydrofolate synthetase, FHS, FTHFS, Formyltetrahydrofolate synthetase.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: YEAL_ECOUT
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ
What are the official names of this protein?
UPF0756 membrane protein YeaL.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURG_SALTI
Sequence: MSGQPKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTSDRMEADLVPKHGIDIDFIRISGLRGKGVKALLAAPLRIFNAWRQARAIMKRFKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNQWLAKIATTVMQAFPGAFPNAEVVGNPVRTDVLALPLPQVRLAGRDGPIRVLVVGGSQGARVLNQTMPQVAARLGDTVTIWHQSGKGAQLTVEQAYAGAGQPQHKVTEFIDGMAAAYAWADVVVCRSGALTVSEIAAAGLPAIFVPFQHKDRQQYWNALPLENAGAAKIFEQPQFTVEAVADTLAGWSREALLTMAERARAVSIPDATERVASEVSRVART
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.