PharMolix/UniProtQA huggingface dataset:
Protein: NRM1_CANGA
Sequence: MVMSLERLPLQEYTKSAMNNLATSGPVIMTSLTEGSSLSKNSVGMGLGMKLPSIHSLINQKNSYNPFQTTLHSKSFSVGDPIKANNSKPLGVTLTSTDSNKRLNTSISALLTDNKSPGKANKPETEKETMNHLVQEDTVDKAHYTELSKKLQIRLQLAYYKYRTKQEHVKFNELKALHSSKPKKASKKNTKRRKLVVSHGNFKTPAKRKEHKLYTTNTHNLQDVSTDISMSSSTSSLMSKRDSSLQFHDSNDTTNDFTTPIRNANKRHLGQKQDTPMSVKAAKSLIFLYSSKV
What is the function of this protein?
Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription.
What are the official names of this protein?
Transcription factor NRM1.
What is the protein family that this protein belongs to?
Belongs to the WHI5/NRM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMN_SYNR3
Sequence: MALKALLGLSQAQLETWAKDQGLPPFRGRQLHDWLYAKGARHWHDITVLPAALRQQEPLPLGRSNELERHLAQDGTLKLLLATDDGLSLETVGIPTRDRLTVCVSSQVGCPMACRFCATGKEGLQRSLEPHEIVDQVLTVREVMQRRPSHVVFMGMGEPLLNSDHVLTAIDCLSRDLGMAMRQITVSTVGVPNTLPRLAELALERLGRAQFTLAVSLHAPDQALREELIPTARAYPYEQLLEDCRHYVAISGRRVSFEYILLGNLNDSPRQAQALAEQVRGFQSHVNLIPYNPIAEEEFQRPEPARVDAFAAALKQRGVAVSVRASRGLDQNAACGQLRRQRQGGR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNMS_ASPPH
Sequence: ESCEYTCGSTCYWSSDVSAAKAKGYSLYESGDTIDDYPHGYHDYEGFDFPVSGTYYEYPIMSDYDVYTGGSPGADRVIFNGDDELAGVITHTGASGDDFVACSSS
What are the official names of this protein?
Guanyl-specific ribonuclease Ms, RNase Ms.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease N1/T1 family.
Protein: RK20_CERDE
Sequence: MTRVKRGYIARRRRTKIRLFASTFRGAHSRLTRTSTQQKMRALVSTHRDRGRQKRDFRRLWITRINAVTHENRVSYSYSRLIHDLYKKQLLLNRKILAQIAISNRNCLYTICNESIK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDTM_SALTI
Sequence: MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICFIATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSGAALMHFVHWKVLFGIIAVMGLLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLATLLLGNLLLPHVWLWSVLGTSLYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVMAVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQRVRQHEAAELAAEK
What are the official names of this protein?
Multidrug resistance protein MdtM.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AGO1_ARATH
Sequence: MVRKRRTDAPSEGGEGSGSREAGPVSGGGRGSQRGGFQQGGGQHQGGRGYTPQPQQGGRGGRGYGQPPQQQQQYGGPQEYQGRGRGGPPHQGGRGGYGGGRGGGPSSGPPQRQSVPELHQATSPTYQAVSSQPTLSEVSPTQVPEPTVLAQQFEQLSVEQGAPSQAIQPIPSSSKAFKFPMRPGKGQSGKRCIVKANHFFAELPDKDLHHYDVTITPEVTSRGVNRAVMKQLVDNYRDSHLGSRLPAYDGRKSLYTAGPLPFNSKEFRINLLDEEVGAGGQRREREFKVVIKLVARADLHHLGMFLEGKQSDAPQEALQVLDIVLRELPTSRYIPVGRSFYSPDIGKKQSLGDGLESWRGFYQSIRPTQMGLSLNIDMSSTAFIEANPVIQFVCDLLNRDISSRPLSDADRVKIKKALRGVKVEVTHRGNMRRKYRISGLTAVATRELTFPVDERNTQKSVVEYFHETYGFRIQHTQLPCLQVGNSNRPNYLPMEVCKIVEGQRYSKRLNERQITALLKVTCQRPIDREKDILQTVQLNDYAKDNYAQEFGIKISTSLASVEARILPPPWLKYHESGREGTCLPQVGQWNMMNKKMINGGTVNNWICINFSRQVQDNLARTFCQELAQMCYVSGMAFNPEPVLPPVSARPEQVEKVLKTRYHDATSKLSQGKEIDLLIVILPDNNGSLYGDLKRICETELGIVSQCCLTKHVFKMSKQYMANVALKINVKVGGRNTVLVDALSRRIPLVSDRPTIIFGADVTHPHPGEDSSPSIAAVVASQDWPEITKYAGLVCAQAHRQELIQDLFKEWKDPQKGVVTGGMIKELLIAFRRSTGHKPLRIIFYRDGVSEGQFYQVLLYELDAIRKACASLEAGYQPPVTFVVVQKRHHTRLFAQNHNDRHSVDRSGNILPGTVVDSKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGLQSLTNNLCYTYARCTRSVSIVPPAYYAHLAAFRARFYMEPETSDSGSMASGSMARGGGMAGRSTRGPNVNAAVRPLPALKENVKRVMFYC
What is the function of this protein?
Involved in RNA-mediated post-transcriptional gene silencing (PTGS).  Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA).  RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression.  Requires DRB1 for directional loading of the small RNA duplex (guide stand and passenger strand) onto RISC for passenger strand degradation.  Unlike animal RISC that associates in high molecular weight complex, Arabidopsis RISC is probably composed only of the AGO1 protein and associated RNA without any other proteins.  Associates mainly with miRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal uridine.  Associates with 22 nucleotide miRNAs to trigger RDR6-dependent secondary siRNAs biogenesis.  This pathway amplifies silencing by using the target RNA as substrate to generate secondary siRNAs.  Binds to miR168 which targets its own mRNA for repression, establishing a homeostatic regulatory loop.  Involved in antiviral RNA silencing by contributing to viral RNA clearance.  Is capable of targeting viral RNAs with more compact structures than AGO7 which favors less structured RNA targets.  May not associate with 24 nucleotide siRNAs involved in chromatin silencing.  Essential for multiple processes in development.  Essential for proper development of leaves and floral organs, and formation of axillary meristems.  Like AGO10, required for stem cell function and organ polarity.
What are the official names of this protein?
Protein argonaute 1.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNL1_ARATH
Sequence: MKRIRDDVYASGSQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVSQKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRTDTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEEDDALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDLLEQFTRFLPASLPSHSAAQHSRSQAQQYSDRGSDPPLLHQMQVEKERRRERAVALRGDYSVERYDLNDDKTMVKIQREQRKRLDKENRARRGRDLDDREAGQDNLHHFPEKRKSSRRAEALEAYSGSASHSEKDNLKSMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESITDGFQRLAGVMSKKLFSSEEQLSRPMKVEEKESEHKPELEAVKETEQCKKEYMGKSIQELDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSGSEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIERLYGDHGLDVIDILNKNPATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEKSQNDDDVLLSISAGYRQPINPNLEYEYLNRAIHEDMFKVVQFSCEELCSTKEQLSKVLRLWENFLEAVLGVPPRAKGTDLVEDVVINPKTLDVNHSTSPNGEAAVSSGGDTARLASRKLKSAANGDENSSSGTFKHGIGLLNKDSTGKENLEDVEIANRDGVACSAVKPQKEQETGNEAEKRFGKPIPMDISERAAISSISIPSGAENNHCVVGKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANGLRSDSSKGTRNSDDPEGPSRNEKEEGELSPNGDFEDNFGVYKDHGVKSTSKPENSAEAEVEADAEVENEDDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSERVLLSVRPLSKHVAAVLCDERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRNCSGGELKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYENVRVLVHEENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQTELLSVSSGKKEEGHDIVLQRNLTGLYDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYFHRKKKKKKTEQLWQRNKVRVERFHRFLSA
What is the function of this protein?
Acts as a transcriptional repressor.  An histone deacetylase (HDAC) activity is required for transcription repression.  May play a role in telomere stability.
What are the official names of this protein?
Paired amphipathic helix protein Sin3-like 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADOK_MYCTA
Sequence: MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA
What is the function of this protein?
Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP).  Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to methyl-AMP, the first step in the metabolism of this compound to an active form that displays antitubercular activity.  Is not active on guanosine, inosine, deoxyadenosine, cytidine, uridine, or thymidine.  Prefers dGTP and GTP to ATP as phosphate donors in vitro.
What are the official names of this protein?
Adenosine kinase, ADK, AK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: HCAF_ECOBW
Sequence: MSAQVSLELHHRISQFLFHEASLLDDWKFRDWLAQLDEEIRYTMRTTVNAQTRDRRKGVQPPTTWIFNDTKDQLERRIARLETGMAWAEEPPSRTRHLISNCQISETDIPNVFAVRVNYLLYRAQKERDETFYVGTRFDKVRRLEDDNWRLLERDIVLDQAVITSHNLSVLF
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase.  Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: VE8E2_HPV18
Sequence: MAVLKWKQHRFSTSDDTVSATQLVKQLQHTPSPYSSTVSVGTAKTYGQTSAATRPGHCGLAEKQHCGPVNPLLGAATPTGNNKRRKLCSGNTTPIIHLKGDRNSLKCLRYRLRKHSDHYRDISSTWHWTGAGNEKTGILTVTYHSETQRTKFLNTVAIPDSVQILVGYMTM
What is the function of this protein?
Plays a role in limiting the replication of viral DNA in keratinocytes.  Recruits the host NCoR/SMRT complex to viral replication foci to mediate repression of both viral replication and transcription.
What are the official names of this protein?
Protein E8^E2C.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E8^E2C protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MED16_MOUSE
Sequence: MDLAYVCEWEKWAKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTHMIHILDTEHPWEVHSVSSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSQVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVAAADGSSASPVKFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSAPRSLDEPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLAEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLVSLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGAASEPDEGLVDECCLLPSQLLVPNLDWLPASDGLVSRLQPKQPLRLRFGRAPTLPSSTSTLQLDGLTRAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKTTAVTQWEQRWIKNCLCGGLWRRVPLSCS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 16, Mediator complex subunit 16, Thyroid hormone receptor-associated protein 5, Thyroid hormone receptor-associated protein complex 95 kDa component, Trap95, Vitamin D3 receptor-interacting protein complex 92 kDa component, DRIP92.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBL_VACFA
Sequence: SVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALFKAQAETGEIKGHYLNATAGTCEEMMKRAMCARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDYVEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKE
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACADM_PANTR
Sequence: MAAGFGRCCRVLRSISRFQWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPRENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
What is the function of this protein?
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats.  The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA.  Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).  Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains.
What are the official names of this protein?
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, MCAD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DAPA_CHRSD
Sequence: MITGSIVALATPMKASGEIDWEALRRLVGFHLDNGTDAIVAAGTTGEPTTMSFAEHFDVIRCVVEEVAGRIPVIAGTGANATSEAVELARYAREVGADLCLSVAPYYNKPTQEGLYQHFKAVAEGGGLPVILYNVPGRTCSDIYNETVFRLAELENIVGLKDATGNLERAEELVDRLKGSDFALYSGDDPTACDFMLMGGHGDISVCANVAPRAMHELCEAAVAGDDERAHQINTRLMPLHTALGVEANPIPVKWALHRMGLAEQGIRLPMTWLSDKYHSTVSEALQLAGVTEG
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TA2R5_GORGO
Sequence: MLSAGLGLLMLVAVVEFLIGLIGNGVLVVWSFREWMRKFNWSSYNLIILGLAGCRFLLQWLIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVFYCKKITTFDRPAYLWLKQRAYNLSLWCLLGYFIINLLLTVQIGLMFYHPPQGNSSIRYPFESWQYLYAFRLNSGSYLPLMVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHITALKSLGCFLFLHLVYIMASPFSITSKTYPPDLTSVFIWETLMAAYPSLHSLILIMGIPRVKQTCQKILWKTVCARRCWGP
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 5, T2R5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL19_CORK4
Sequence: MNILDKVDAASLRDDIPEFRSGDTVDVHVKVIEGQKSRIQVFRGVVIRRQGSGVRETFTVRKVSFGIGVERTFPVHTPNIDHIEVLTRGDVRRAKLYYLRNLRGKAAKIKERR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RECX_STAA1
Sequence: MPKITKIEVQKKNKERFNLFLDEQFEMGIDIDTLVKFNLKKGQQLEAADMAEIQKYDHYRIGLNKAIQYLSYKKRTEKEVIQYLQKEEISEQAISEVIEYCYREKLIDHQDYAESLKNTMIRTTDKGPKIYQQKLYQLGIEPNIIEMFTELYREQQELDDIIQIAEKISKTKKGPQNKVKEKVMQSLIQKGFEMETIHAVLNEMDFTQDEAVLDDLLQRDLEKIYNKNRKKYTQQKLISKTIEGLMRKGYKYDKIKAKLEESGIADGTEEIE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_PSEPU
Sequence: MAYSYTEKKRIRKDFSKLPDVMDVPYLLAIQLDSYREFLQAGSIQGSLPRRRLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTFAVPLRVKVRLIIFDKESSNKAIKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQMHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPASVLLRALGYSTEEVLNTFYTTNVFHISGEKLSLELVPQRLAGEVAVMDIHDETGKVIVEQGRRITARHINQLEKAGVKQLDVPMEYVLGRTTAKAIVHPATGEILAECNTEMTTELLIKVAKAQVVRIETLYTNDIDCGPFISDTLKIDTTSNQLEALVEIYRMMRPGEPPTKDAAETLFNNLFFSAERYDLSPLGRMKFNRRIGRTEIEGSGVLSKEDIVEVLKTLVDIRNGKGIVDDIDHLGNRRVRCVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAVKEFFGSSQLSQFMDQNNPLSEITHKRRCSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLAAYARTNQYGFLESPYRVVKEGVVSDDIVFLSAIEEADHVIAQASAAMNDKKQLIDELVAVRHLNEFTVKAPEDVTLMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMERNVARDSGVCVVRRRGGVIDSVDASRIVVRVADDEVETGERRVDIYNLTKYTRSNQNTCINQRPLVSKGDKVQRGDIMADRASTDMGELALGQNMRIAFMAWNGFNFEDSICLSERVVQEDRFTTIHIQELTCVARDNKLGPREITSGIPNVGEAALNKLDEAGIVYVGAEVGAGDILVGKVTPKGHTQLTPEEKLLRAIFGEKASDVKDTSLRVPTGTQGTVIDVQVFTRDGVERDSRALAIEKMQLDEIPQDLNEEFRIVEGATFERLRSALNGQVVDGGAGLKKGTVITDEVLDGLDDGQWFKLRMAEDALNEQLEKAQQYIVDRRRLLDDKFEDKKRNVQQGDDLAPGVLKIVKVYLAIRRRIQPGDKMAGRHGNKGVVSVIMPVEDMPHDANGTPVDVVLNPLGVPSRMNVGQILETHLGLAAKGLGEKIDRMLEEQRKAAELRVFLTEVYNEIGGRQENLDEFTDEEILALANNLKKGVPMATPVFDGAKEREIKAMLKLADLPESGQMVLFDGRTRNKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMAESFNVLIKEIRSLGIDIDLETE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CYSH_GEOKA
Sequence: MLTYDQWEKAEKPSFPSDNETKGALDVLAWAYREYGDEIVYACSFGIEGIVLIDLISQVKPDAEIVFLDTGLHFPETYDTIAKVKEKYPSLRIVMKQPRLTLEEQKAQFGDELWKRDPNKCCELRKVIPLREVLTGVTAWISGLRREQSPTRRHVEYINKDDKFRSIKVCPLIHWTWKDVWNYVYKRHLPYNVLHDRGYPSIGCAPCTAPATDPNDLRSGRWAGQGKTECGLHLA
What is the function of this protein?
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
What are the official names of this protein?
Adenosine 5'-phosphosulfate reductase, APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSCB_ARTOC
Sequence: MGGRMPFNQSFWEEFLMGREGRLPTLPEISHVSKRVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQVKQASFLRLQRAPSQLIHSKKGLPVWISRISSFLRTHNLELSYVLLTHWHGDHTGGVPDLLAHSPSLADKIYKNCPDAGQNPITDGQIFSVNGATVRAVFTPGHSVDHMCFQLEEENALFTGDNVLGHGFSVAQDLGRYMHSLGDMASLGCGIGYPAHGAVIGNLPEKLEEYMKHREGRERMMLSTLTREQAQGEGGRVGETKGGLTLNEIVIAMYGRVPQEVVEKALAPSLLQVLWKLAEDRRVGFKPGDPLKRRWFALDQRKRNRVRGYPS
What is the function of this protein?
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997).  The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity).  The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity).  The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity).  The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity).  Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity).  Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity).  On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity).  Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
What are the official names of this protein?
Lactamase-like protein nscB, Neosartoricin B biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: RWDD3_RAT
Sequence: MAEEMRQELSALAAIFCGPHEWEMLSCSETDGAVFRIHTTAEGLAGEDVPLELAFHLPAGYPSCLPGISVNSERLTRAQCVTVKEKLLGEARRLLSEPMVHELVLWTQQNLRHILSQTETESSNGTCTLPESSTVDGGLWMTLLRLDHMRARTKYVKVVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVLSETKVQTEHKRFLAFEVKEYSTLEELQKEFETAGLQELFSECVLGLVK
What is the function of this protein?
Enhancer of SUMO conjugation.  Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1.  Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity.  Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia.  Has no effect on ubiquitination.
What are the official names of this protein?
RWD domain-containing protein 3, RWD domain-containing sumoylation enhancer, RSUME.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots.