PharMolix/UniProtQA huggingface dataset:
Protein: TSN2A_DROME
Sequence: MGIGYGASDEQLEKQIGCVKYTLFCFNIVAWMISTALFALTVWLRAEPGFNDWLRILEAQSFYIGVYVLIGISIVMMAVSFLGCLSALMENTLALFVFVGTQVFGFIAIVAGSAVLLQFSTINSSLQPLLNVSLRGFVATSEYTYSNYVLTMIQENIGCCGATGPWDYLDLRQPLPSSCRDTVSGNAFFNGCVDELTWFFEGKTGWIVALAMTLGLLNVICAVMSFVLVQAVKKEEEQASNYRR
What is the function of this protein?
Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh.  Important for barrier function of the midgut epithelium.
What are the official names of this protein?
Tetraspanin-2A.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Apicolateral cell membrane; Multi-pass membrane protein. Cell junction, septate junction.
Protein: KAB16_OLDAF
Sequence: GIPCAESCVYIPCTITALLGCKCQDKVCYD
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Kalata-B16.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: NYLC_KOCS2
Sequence: MNTTPVHALTDIDGGIAVDPAPRLAGPPVFGGPGNAAFDLVPVRSTGRETLRFDFPGVSVGSAHYEEGPTGATVIHIPAGARTAVDARGGAVGLSGGYDFNHAICLAGGASYGLEAGAGVSGALLERLEYRTGFAEAQLVSSAVIYDFSARSTAVYPDKALGRAALEFAVPGEFPQGRAGAGMSASAGKVDWDRTEITGQGAAFRRLGDVRILAVVVPNPVGVIMDRAGGIVRGNYDAQTGVRRHPVFDYQEAFAEQLPPVTQAGNTTISAIVTNVRMSPVELNQFAKQVHSSMHRGIQPFHTDMDGDTLFAVTTDEIDLPTTPGSSRGRLSVNATALGAIASEVMWDAVLEAAK
What is the function of this protein?
Involved in the degradation of nylon-6 oligomers.  Degrades cyclic and linear oligomers of 6-aminohexanoate (Ahx) with a degree of polymerization greater than three by an endo-type mode.  Cannot use Ahx cyclic dimer or the Ahx linear dimer.
What are the official names of this protein?
6-aminohexanoate-oligomer endohydrolase, 6-aminohexanoate oligomer hydrolase, Ahx endo-type-oligomer hydrolase, Nylon hydrolase, Nylonase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S58 family.
Protein: AROE_HERAR
Sequence: MSTMTDRYAVIGNPIAHSKSPDIHARFAAQTQQDMRYEPLLAPLDGFLATVQDFVRNGGKGVNVTVPFKLEAYALATTLTERARAAGAVNTLKFDGADMLGDNTDGFGLVSDIVRNAKVEIANKSVLLLGAGGAARGVLLPLLHEQPARLVLANRTHSKALDLAHRFAAQPRLKVSTFADLDDSFDIVINATAASLASEVPPISPRVFTAHTLAYDMMYGAQPTAFMRFAAQHGATVRDGLGMLVEQAAESFYLWRGVRPETAAVFAELRAQL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: AROQ_HALHL
Sequence: MPKLLLLHGPNLNRLGTREPERYGRLTLQDIETRLRSICDAAGVQLCSAQSNHEGELIDRIHAAADEGVEFIVINPAALTHTSVGLRDALLAVALPFIEVHLSNVHAREAFRQHSYLSDIAEGVITGLGADGYDFAARAAIRRMGGQA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: PCCB_ROSDO
Sequence: MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCTDFNMQDQKPAGDGVVTGWGTINGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGAPVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQISMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRRLVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQEEFAKNIITGFIRLEGRTVGVVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLIDVPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRKAYGGAYVVMSSKHLRADFNYAWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPRSTRKRVARAFASLRNKSVQMPWKKHDNIPL
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:20725044).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (Probable).
What are the official names of this protein?
Propionyl-CoA carboxylase beta chain.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: GLO2_BRUA2
Sequence: MEQRLEIEQFICRSDNYGVLIHDPESALTATIDAPDAYAIEAALERRGWTLDFIFTTHHHLDHVEGNEPLKEKFGVSIIGPEAEKAKIPGIDRTVKGGDEFTFGLFKVKVISTPGHTAGGISYYLPDAKVVFTGDTLFALGCGRLFEGTPATMFHSLEKLVALPGDTALYCGHEYTQNNARFALTIDPDNSALKERAKEIARLRAHERMTLPSTIALEMATNPFLRWHDRTIRARLGLQDAPDEAVFAEIRKRKDMF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: KHSE_SULIY
Sequence: MECKRARAYSSSANLGSGFDILSMAHTAFFDTVEICVETKNSENIVIESNSKIPLEPNRNSATYPLVRIMEERGIKASLRVKVIKGIPEGLGLGSSGASATAAVMAFSSLFNLNLSKEDLVRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVNPVKVVEIPLNYSFNILLFVPLNIHIEEKTKKAREMVPKTVKLSDYINNSRYISSLLIGFVKGERDLIRLGLNDEIVEKARLPLFPYYPKIKEIAIKYDAVGSCVSGAGPSILVLTDKMTDENKIAEEGTKTCNEFNVECEVIKAKIAGGVEVERRN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_DAUCA
Sequence: MKSNPGITVIKQNASNVMEKTLKEEGQSRSNSEDSDDDKPLSHKLSSGALNGNSHHIRMGSNLSCPSPYTSPKPRIIKGPEDEMLLSSELQLNAGASNAESSDSDESKPLASELEDPSSSLNKRPLIQPKNSDPSPSKKAKLSEPSAPTNRKLKTAEQEEAAADDDPSISNRNKKSTTPASKVSDKKKRPDVSASVNKVDFSKSLKVPLVLVKGRNGQPLVHNGVIFPPLYKPHGVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSDWRKILGEKHIIQNLEDCDFTPIYEWHQREKEKKKQMSTDEKKAIKEGKDETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRASKDPQVKKNVYSQIDITINIGKDAPIPEPPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGKVTREKYEKSRKLKDYIEGIRAAAYTKDFASKDSKKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVETKRPNILKFDFLGKDSIRYQNEVEVEPRVFSAIEQFRSGKEGGDDLFDQLDTSKLNAHLKELMPGLTAKVFRTYNASITLDEMVRCKLLSRETKGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMVRLNEKIEELKGLLKELQEDLTRVNKGKPPLKNSDGKPKRNLNLKRYKGKLLKLIQKLRKWSETRRLSVTKKIAQTNTKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHDVPIEKIFNKSLLAKFAWAMDVVLIFRF
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCAP_MMVR
Sequence: MANINIPDDLVSKYSEDVKDLTQKAGSIPSSKSLIPQTAFTPDELRRSLKFWQVTTKVAATVASDWTNLATALTNGTFSATHLRTLCELAFNLKAPTGTGTIFIHEIADPWKGCIDANAPDTVAIPATDSDVNMSTVSSGSTASGTEDAEVKMKAISFLCCTLLRLSVKEPSHIMQAINSIRQRFGSLYGVSSPTLNSVTFNRSQLSRIKQGIETYPSARGTVFYYTRYADATHGYTTKEYGICRFLLFQHLELEGMHIYKMLLALLGEWSTVPIGLLLTWIRNPRSKLAINEIVKIVKELDKPEVDKGWKYARMVNNTFFLDLSSRRNTYLCAVLASLNKKNVPQGSGEYADPTNIAVIKNMDQSVKSQVATDVTLIERIYEKYLVSAGGDEAGTAYALSRGVKRSSPPSQEGGQSGQSGGTPMEVDGASGRGAAGPAPKKTRSGL
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the nucleorhabdovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: RECR_ACTP2
Sequence: MQISPLLENLMEALRALPGVGPKSAQRMAYHLLQRNRSGGINLSKALNEAMTHIGHCRSCRTFTEEDECNICKNPRRQMSGQLCVVEMPEDIQAIEQTGQFSGRYFVLMGHLSPLDGIGPREIGLDLLQSRLENESFHEVILATNPTIEGDATANYIAEMCRIHNVKVTRIAHGIPVGGSLEMVDGTTLSHSFAGRRDVSL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NUP_CANAX
Sequence: MKLSTLFTLATTISTLTTFTIASPVVVVEKRAINETALAEDIPTTKNNHAQASYGKPFAIYQPKAFIISMFSLERDPWLKAMDFVHNITIPGLSPVYPDIHCTTNYTICQITTGEGEINAASSISALTLNPLFDLTKTYFLVGGIAGGEPNYTTIGGVTFAKYAVQVGLEYQLAYEDYHKTNPDWISGYIPYGTDDQNTYPGNVYGTEVFEVNEKLRDRAVELASKVHLNNGTEGNAKFRKLYNETAAQGLPKVVKCDSLTSDNYFTGNVLNDYFANFTLLMTNGSATYCSTAQEDNATLEVMTRLAKHGLVDYDRIMIMRTISDFSRPPPSMSAYEYFFNRSDGGISASLENLVIAGTPIIHDIVQNWDKIYKSGEKYSSKNYVGDIFATLGGKPDFGKESFDTA
What is the function of this protein?
Nucleoside permease that transports adenosine and guanosine.  Does not show any transport activities towards cytidine, adenine, guanine, uridine, and uracil.
What are the official names of this protein?
Purine nucleoside permease.
What is the protein family that this protein belongs to?
Belongs to the NUP family.
Protein: DNAJ_MANSM
Sequence: MAKQDYYETLGVQKGADEKEIKRAYKRLAMKYHPDRTNGDKAAEEKFKEVNEAYEILMDKEKRAAYDQYGHAAFEQGGFGGGAGGFGGGFGGFGGFEDIFSEMFGGGASRQRVVRGEDLRYDIEITLEEAVRGTTKDIKINTLAACDHCDGSGAEKGSKVETCPTCHGHGRVRRQQGFFMTETTCPTCQGSGKKIEKPCKHCHGDGRVHKKKNLSVKIPAGVDTGNQLRLSGEGAAGENGAPAGDLYVVIHVKDHHIFERDGSNLYCEVPISFTMAALGGEIEVPTLDGRVKLKIPAETQTGKLFRMRGKGVTSTRAGYAGDLICKIIVETPVKLNEEQKELLRKFEESLEGQSKQRPKSSSFLDGVKKFFDNLGK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_RICCK
Sequence: MTYIKGNTGKWEYVIGLEIHAQISSKSKLFSGSSTTFAAMPNSQVSYVDAAMPGMLPVLNKHCVHQAIKTGLALKAQINKYSVFDRKNYFYADLPQGYQISQFYYPIVQNGTMKILTSTGDLKTIRINRLHLEQDAGKSIHDQSPHYSFIDLNRAGIGLMEIVTEPDISSPEEAAEFVKKLRSLLRYIGSCDGDMEKGSMRCDANISVRRSGEPLGIRCEIKNINSIRNIIKAIEFEAKRQVDLIESGGIVIQETRLFNADSGETRTIRLKEEAIDYRYFPDPDLLPLIISDELINKLKANLPELPDQKIEKYMKEFGLSKYDAEVIVADESVAEYFEQAANECNPKMLTNWLTSELFGQLNKASIGISKCKITPSNFAKLIKLIENDTISGKIAKTVFEIMFETGKAPDKIVEEKGLVQVSDNNVLNTVIDEVITENPKSVEDYRSGKEKLFSFFVGQIMKKTGGKANPILVNQLLKEKLGS
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DNAK_ACTP2
Sequence: MGKIIGIDLGTTNSCVAVMDGDKARVIENAEGARTTPSIIAYTDNETLVGQPAKRQAITNPKNTLFAIKRLIGRRFESEEVQRDIKIMPFEITRADNGDAWVNVKGDKLAPPQISAEVLKKMKKTAEDFLGEAVTEAVITVPAYFNDAQRQATIDAGRIAGLDVKRIINEPTAAALAFGLGSTKENQVIAVYDLGGGTFDISIIEIDNFDGEQTFEVLATGGNTHLGGEDFDNRVIDYIIDEFKKEQGVDLRNDPMALQRVKEAAEKAKIELSSAQSTEVNLPYITADATGPKHLAINVTRAKLEALVEDLVASSIESLKTVLKDAGKSVNEINDIILVGGQTRMPLVQQKVAEFFGKEARKDVNPDEAVAIGAAVQGGVLKGDVKDVLLLDVTPLSLGIETMGGVMTVLIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKQASANKSLGQFNLEGINPAPRGMPQIEVTFDIDANGVINVSAKDKNTGKEQQIRIQASSGLSDEEIEQMVRDAEANAEADKKFEELVQARNQADGIAHATRKQIEEAGDALNADDKAKIEAAIADLEKAAKGDDKAEIDAKTEALIKASEPLMQAAQAKAQAGEQPQQSAKDDGVVDAEFEEVKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ICLN_HUMAN
Sequence: MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
What is the function of this protein?
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161, PubMed:10330151, PubMed:11713266).  Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:10330151).  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161).  Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161).
What are the official names of this protein?
Methylosome subunit pICln, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, I(Cln), Chloride ion current inducer protein, ClCI, Reticulocyte pICln.
What is the protein family that this protein belongs to?
Belongs to the pICln (TC 1.A.47) family.
Protein: Y3349_BACAC
Sequence: MKLGIVIFPSKMIQDKANGLRKRYDPHYALVPPHITLKTPFETQDEQLESIVNKLHTIASKTNPFTLHVGKVGSFAPVNNVIYFKVEKTPELTFLNEEMHSGFFTQEREYAFVPHLTIGQGLSDAEHADVLGRLRMKDFYYEQPIDRFHLLYQLENGTWTVHETFRLGKGNN
What are the official names of this protein?
Putative phosphoesterase BAMEG_3349.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: PSAA_PROHO
Sequence: FDSHTSDLEDVSRKIFSAHFGHLAVIFIWLSGAYFHGARFSNYTAWLSDPISIKPSAQVVWPFRSIFGQEILNGDVGGGFHGIQITSGLFHLWRACGITHSSELYATAIGALVMAGLMLFAGWFHYHKAAPKLEWFQNVESMLNHHLSVLLGCGSLGWAGHLIHISLPVNALLDAGVSPADIPLAKDYVLDAGYMAKFSQLCRGLNPFFTLNWGVYSDFLTFKGGLNPQTGSLWLTDIAHHQLAIAVLFIIAGHMYRTNWGIGHDMKALLDGHKGPVGEVGTGHAGLYEILTTSWHAQLAINLALLGSLSIIVAHHMYAMPPYPYLAIDYPTQLSLFTHHVWIGGFLIVGAGAHAAIFMIRDYDPAKNVDNLLDRVIRHRDAIISHLNWVCIWLGFHSFGLYIHNDTMRALGRPQDMFSDSAIQLQPIFAQGIQSIQAAVAGSAQAPWVGAATSPVWGGDTIAVGGKVAMSAIPLGTADFMVHHIHAFTIHVTVLILLKGVLYARNSRLVPDKAELGFAFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSLSIVIFHFSWKMQSDVWGTVYPDGSVLNITVGNFAESALTINGRLRDFLWAQAASVINSYGSALSAYGLMFLAAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSITQGRAVGVAHYLLGGIATTWAFFLARIISVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity).
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: LLDD_XANAC
Sequence: MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWIREFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIADISADALSRVTRERADAISP
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SEP15_PIG
Sequence: MAAEPGGWLGPALGLRLLLATALQMVSAFGAEFSSESCRELGFSSNLLCGSCDLLGQFDLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLQRV
What is the function of this protein?
May be involved in redox reactions associated with the formation of disulfide bonds (By similarity).  May contribute to the quality control of protein folding in the endoplasmic reticulum.  May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).
What are the official names of this protein?
Selenoprotein F, 15 kDa selenoprotein.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein M/F family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
Protein: E1A_ADECR
Sequence: MKLTLEPAPRCLHEYVSQLLEDWQPECLSCEYSHGGSSPPSLHDLFDLELENSRSPSPLLCDWCAEADSESTISTETDVGFTLNTPPVSPLPSYSTSPASIPEDMLLCLEEMPTFDDGDEVRSATTSFEHWENNFDPNVGSFFGCLRCAYYQEQGENSICGLCYLKALAEGKIF
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E1A protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome.  Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore.  This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K.  Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection.  Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation.  The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.
What are the official names of this protein?
Early E1A protein, Early E1A 20 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1A protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RECR_MYCTO
Sequence: MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPSDIDRLTGVLAKVRDGVRFCAVCGNVSDNERCRICSDIRRDASVVCIVEEPKDIQAVERTREFRGRYHVLGGALDPLSGIGPDQLRIRELLSRIGERVDDVDVTEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRVLA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ANMK_ACTP2
Sequence: MTKNLYLGVMSGTSLDGVDLCVMDFAKNPPKLTACGFTPMPEDLRTDLSHLLKSGETSLQKLGEIDHRLGLLYAESIKRFLAEHQLSASDIQAIGCHGQTVWHSPNGNFPFTMQIGDMNLVAAHTGITTIADFRRKDMAVGGQGAPLVPAFHEGIFASPERLTVVLNIGGISNISVLAPQQPTIGYDVSVGNALMDSWIELHQAKRYDKNAEWAKTGTLIPALLDSLLDEPFFKLPAPKSTGRELFNLEWLAKKSANLTAYRPEDVQRTLAEFTVQSVVNELKTLESEKQCLLLACGGGARNPLLMQRFSELLPKWQVATTDEYGLDIDYVEAAAFAWLAYQRVHNLTNNLPSVTGAKEPVSLGVIYPK
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.