PharMolix/UniProtQA huggingface dataset:
Protein: UVRC_ACTP7
Sequence: MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHNYIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRSRPCLQYQIGRCLAPCVEGYYSQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQFVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLTELADTFVGQFYLQMNQHRTIPNQIIIDQPLSEATALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDISHTMGNQTVASCVVFDENGPLKSDYRRFNIEGITGGDDYAAMEQALLKRYGRHLEEEKIPDIIFIDGGKGQLNRALETFASLNVSWDKRKPLLIGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESIAGVGAKRRQALLKYLGGMQGVKSATLEEIQSVPGISKQLAEVIFDTLQHS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGK3_ARATH
Sequence: MDSPVSKTDASKEKFVASRPSTADSKTMRGCGLANLAWVGVDKVELRQRLMMPEYLRLAMRDCIKRKDSSAIPDHLLLPGGAVADMAPHAPMVVFINPNSGGRHGPVLKERLQQLMSEEQVFDLTEVKPHEFVRYGLGCLEKVAAEGDECAKECRARLRIMVAGGDGTVGWVLGCLGELNKDGKSQIPPVGVIPLGTGNDLSRSFGWGGSFPFAWRSAVKRTLHRASMGPVARLDSWKILVSMPSGEVVDPPYSLKPAEENELDQGLDAGIDAPPLAKAYEGVFYNYLSIGMDAQVAYGFHHLRNTKPYLAQGPISNKIIYSSFGCSQGWFCTPCVNDPGLRGLRNIMKIHIKKVNCSQWEEIAVPKNVRSIVALNLHSYGSGSHPWGNLKPDYLEKRGFVEAHCDDGLIEIFGFKQGWHASFVMAELISAKHIAQAAAVRFELRGGDWRDAFLQMDGEPWKQPMSTEYSTFVEIKKVPYQSLMINNE
What is the function of this protein?
Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule.  PA is required for plant development and responses to abiotic stress and pathogen attack.  May be involved in the accumulation of PA during cold stress (By similarity).
What are the official names of this protein?
Diacylglycerol kinase 3, AtDGK3, DAG kinase 3, Diglyceride kinase 3, DGK 3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
Protein: PRP6_BOVIN
Sequence: MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKSQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDKAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSVKLEWVLGNLVAAQELCEEALKHYEDFPKLWMMKGQIEEQEELVEKAREAYNQGLKKCPHSTPLWLLLSRLEEKVGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIASTLMAKALQECPNSGVLWSEAIFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQREEVRRRCENAEPRHGELWCATSKDIANWQRKIGEILVLVAARIKNTF
What is the function of this protein?
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome.  Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
What are the official names of this protein?
Pre-mRNA-processing factor 6, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles.
Protein: FM521_ASPTN
Sequence: MASVALIGCTGMVGSHILTSLLAHPSVARVDTISRRTPNAASAAQAKLTTFVSDDTSKWASQLSALTPIPSIFFSSFGTTRAAAGGFENQYKIEHGLNVEMARAARDAGTKVYVLVSSSGASKDSSIPYSRMKGEIEEEAKAMGFEHTVILRPGLISGTREESRPLEAAARYIAGFAGKVHSGLKDSWAQDADVIAKAAVNAGLKALEGDVPAGSEKVWVLGGSDIIKLGKE
What are the official names of this protein?
Protein fmp52-1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FMP52 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein.
Protein: SVBP_HUMAN
Sequence: MDPPARKEKTKVKESVSRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE
What is the function of this protein?
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31270470, PubMed:31235911, PubMed:31324789, PubMed:31171830, PubMed:31235910).  This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830).  Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017, PubMed:30607023).  Plays a role in axon and excitatory synapse formation (PubMed:31235911).
What are the official names of this protein?
Small vasohibin-binding protein, Coiled coil domain-containing protein 23.
What is the protein family that this protein belongs to?
Belongs to the SVBP family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Detected both intracellularly and extracellularly (By similarity). Within cells, localizes mainly to the apical part of the cell (By similarity).
Protein: IF3_STAAR
Sequence: MSTIAKDQTQINDKIRAKELRLISQDGEQIGVKSKREALEMAERVDLDLVVVAPNAKPPVARIMDYGKFKFEQQKKEKEMKKKQKIINVKEIRLSPTIEEHDFQTKLKNGRKFLTKGDKCKVSIRFRGRAITHKEIGQRVLEKYADECKDIATVEQKPKMDGRQMFIMLAPTAEK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPH18_ARATH
Sequence: MCPSSFRLILSVILIAFLFVGLCEAHRHINVDIINDIGPNVQLGLHCKSKGKDLGPQSLAPHQHWGFTASLNVWETTLFFCHFVWENQSRWFDILKEKRDTIVCKYHPCVWSIRPSGPCRLTDHEKCYPCNADI
What are the official names of this protein?
S-protein homolog 18.
What is the protein family that this protein belongs to?
Belongs to the plant self-incompatibility (S1) protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: DXR_RIPO1
Sequence: MKKITILGSTGSIGTQTLDIVQQYPDQFQVVGLATRNNGELLAQQIKQFRPEIVAICQESQLNTIKDAIASLDYSPILLTGEAGVVEVARYGDSESVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLRRIILTASGGAFRDWPVEQLKFVTVEDAIKHPNWSMGRKITVDSATLMNKGLEVIEAHYLFGLEYDKIDIVIHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWEPLDLVKAGSFTFREPDHHKYPCMQLAYAAGRSGGAIPAVLNAANEQAVALFLEEKIAFLEIPKLIEMACDRFTNQNTSTPTLEDILEADRWARQEVIKGSQEIAKGNKIMSLT
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PHS_RHIEC
Sequence: MKSERLERTAVEAELAGLAGWALNDAASSISKTFKFSNFIEAFGFMTEAAITAEKLNHHPEWFNVYSRVDVTLNTHDAGGLTELDFKLARAMEKAAARRLR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: Y2790_YERE8
Sequence: MRNVTSLGWQYLRAFVIIYLCLWAGKAVTLLLPISIPGSILGMLILFALLSSQILPSTWVKPGCHLLIRYMALLFVPIGVGVMQYYDQLTKQFGPIVVSCFVSTLVVMLVVGYSSHYVHRERKVMGSPTHTEEDK
What are the official names of this protein?
UPF0299 membrane protein YE2790.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EPMA_ECOLC
Sequence: MSETASWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWLMTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCPAAESLSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSNVADTEEDRDTLLQLLFTFGVEPNIGKEKPTFVYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQNLIDALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAFSVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'.  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: Q0010_YEAST
Sequence: MYYIMFLYNMLLIIILIFYSIVGVPIIIFNNNYYWDPDIFLFIIYYFIKFIIIFNLYLYYMINYIVYTPSGSPPGRGTYILLYNMLYSYNMFIDYVMKFITCVTYMYLMFWLLSPTPSPYYVSEVPVS
What are the official names of this protein?
Putative uncharacterized protein Q0010, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: OTU1_DROPS
Sequence: MTGSFSVKLKSKKGQFIVKDLNQNTTLGELKTRIAQATAIQELQLHVLVGYPPKPLDLSENRENQNLKTVGINSGETLIVEEKAGAAGPTSTPLASGSGSSTMEDDEALARRLQAEEDAEHLRQVSSGGSIETGALNIVQSLEPVISPEESGPNGNFNGILLKKVVPADNSCLFTSIRFVLNGKVDNEGSEMMRHIIAQEVSADTQQYNDAVLGKSNSDYCAWIQKADSWGGAIEVSILSNYYGIEIDVVDIQNAIINRFGEDKNFGLRVFLLFDGIHYDPLYMETQQNSVPATIFPVEEMGVYQQAEQIANEAKSSRQFTNVDKFTLRCMDCDVMLVGQGQAQEHAKKTGHENFEEI
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
What are the official names of this protein?
Ubiquitin thioesterase OTU1.
Protein: TIAS_ARCFU
Sequence: MRVWVGIDDTDSSRGMCTTYLAVLAMERVERELGKVIGFPRLIRLNPTIPYKTRGNGAVSFLVEVDDVGELVDVVNEVIIEHAMLDDEKTNPGAVFVDEELAVKLKPFADKAIKDVLQIDEALFVIGKYFIPHLRHKKGRGLIGALAAVGAELEDFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTFDNVDWCNDVVVCIPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATDMHLIGEEEVHRLENYRSYRLRGRVTLEPYDIEGGHVFFEIDTKFGSVKCAAFEPTKQFRNVIRLLRKGDVVEVYGSMKKDTINLEKIQIVELAEIWVEKNPICPSCGRRMESAGRGQGFRCKKCRTKADEKLREKVERELQPGFYEVPPSARRHLSKPLIRMNVEGRHIFR
What is the function of this protein?
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
What are the official names of this protein?
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS, tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the TiaS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_HYPCP
Sequence: MSRYRGPRVRIIRRLGTLPGLTNKTPQLKSSSINQSISNKKISQYRIRLEEKQKLRFHYGITERQLLNYVRIARKAKGSTGEVLLQLLEMRLDNVTFRLGMAPTIPGARQLVNHRHILVNDCIVDIPSYRCKPQDFITIKNQRKSETIISKNIEFYQKSKIPNHLTYSSLEKKGLVNQILDRESIGLKINELLVVEYYSRQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RECR_LEIXX
Sequence: MYAGIVQELIDELGRLPGIGPKSAQRIAFHILQTEAFDVTRLAEVLLEVRDKVRFCEICGNVSEQATCSICRDPRRDPALICVVEEAKDVVAIERTREFRGLYHVLGGAISPIDGVGPDDLRIRQLVQRLADGTVQEVIIATDPNLEGEATATYLSRLLTTLEVRVTRLASGLPVGGDLEYADEVTLGRAFEGRRQVS
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: MNMA_ALKEH
Sequence: MGKTDKVVVGLSGGVDSAVAAMRLLEAGHHVEGLFMKNWEDDDTLTHCAAEEDLAEAQAVADHLGIRLHRANFAARYREQVFEVCLREYRAGRTPNPDILCNQRIKFRAFLDHALSLGASKVATGHYAGVGEQGGRFTLLRGEDPHKDQSYFLYTLGQAQLRHSLFPLSELPKPEVRRQAAAAGLPNHARRDSTGICFIGERDFRAFLSRYIQRSPGPMETPEGQVVGEHQGLAFYTLGQRRGLGLGGLPDHDEGAWYVADKDMARNALIVVQGHAHPRLLSTALVADELSWVAGAPPTLPLRCTVKSRYRQQDQPCALEAGPSPTSVVVRFDTPQRAVTPGQSVVFYQGRVCLGGGIIQTRTPVE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1614_METJA
Sequence: MKLGVSTSLFLDTDKNLSDALEILEERVKYVELGCDGNLNVMSDGNIELAQSYDLKYTLHCPITDLNLSSYRERIRKVSLDFVRDVLEVAIKVDAKLIVLHPGYCVFKYDYEKALNSLIKSLNDLNNIQEEFGVQITIENMPSYDMFMFRNPDKEIIENLGELKITLDIGHSFLNKNIENFLKISDKIAHIHIHDNNGEFDEHLCIGKGKINFNNFKKDLKKINAIKMIELQNKSIDDLDLCIDNLKEILR
What are the official names of this protein?
Uncharacterized protein MJ1614.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1311.
Protein: PFP_NAEFO
Sequence: MLSSSHLPTTIVTPKNVPTLGVLVGGGPAPGINGVIGAVTIEAINNGYRVLGFLEGFQNLILQDDSKIVELTIDSVSRIHFEGGSILKTSRANPTKKQEDLQKVVKQLQKFNVSLLVTIGGDDTAFSSMSVAKAANNEIHVVTLPKTIDNDLPLPYGIPTFGYETAREFGANVVRNLMTDASTASRYFIVVAMGRQAGHLALGIGKSAGSHLTLIPEEFLPTTDSTEPEVTFSRICDMIEASIIKRLYTSKKDHGVIVLAEGLLEYMSTDELKQAFGSSLKYDAHDHIMLAELDFGRLVRDEMRERMNRRGLKIAFTEKNLGYELRCAPPNAFDREYTRDLGNGAVRYLLNGGNGALITVQGVKMVPLSFDDLKDPRTGKTRTRQVDVSSEGFQVAKRYMIRLEKKDFEKEETLKGLAATAKCSVEDFIKQFKYLVQ
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, 6-phosphofructokinase, pyrophosphate dependent, PPi-dependent phosphofructokinase, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_CORU7
Sequence: MIRVGVLGAKGRVGTTIVAEVEQNPNLELSAALDHGDDLQELVDAKTDVVVDFTQPDSVMSNVEFCIRNGIHAVIGTTGWTEERYETVRSLLQDSPKVGVLVAPNFAISAVLTMKFAEIAAPFFESAEVIEFHHPNKLDAPSGTAVHTAEGIARARREAGLEEQPDATAQSLDGARGSDVQGVPVHAVRMTGMVAHEEVIFGTRGQSLTIRQDSYDRESFVPGVVIGVEKIADNPGLTIGLEKFLGLD
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIG10_HUMAN
Sequence: MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLSLSVHYSPKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPLPPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEARMPKGTQADYAEVKFQ
What is the function of this protein?
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.  Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity).  The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.  In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025).  Involved in negative regulation of B-cell antigen receptor signaling.  The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity).  In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity).  In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598).  Plays a role in the control of autoimmunity (By similarity).  During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes.  The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
What are the official names of this protein?
Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
Protein: RF1_CHLFF
Sequence: MEKKILEYLKRLEEVEVKISDPEIFNNPKEYSSLSREHARLTELKNVYDKVLRHEKILNDDKHALAQEKDPEMIAMLEEGIQSGKSEIEKLYKILENLLVPPDPDDDLNVIMELRAGTGGDEAALFVGDCVRMYHLYASAKGWKYEELSASESDIGGYKEYVMGISGTGVKRLLQYEAGTHRVQRVPETETQGRVHTSAITVAVLPEPAEDDEEVFVDEKDLKIDTFRASGAGGQHVNVTDSAVRITHLPTGVVVTCQDERSQHKNKAKAMRILKARIRDAEMQRRHKEASAMRSAQVGSGDRSERIRTYNFSQNRVTDHRIGLTLYNLDKVMEGDLDTITSALVSHAYHQLFQNGNEENS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MV3K_THEAC
Sequence: MTYRSIGSTAYPTIGVVLLGGIANPVTRTPLHTSAGIAYSDSCGSIRSETRIYADEATHIYFNGTESTDDNRSVRRVLDRYSSVFEEAFGTKTVSYSSQNFGILSGSSDAGAASIGAAILGLKPDLDPHDVENDLRAVSESAGRSLFGGLTITWSDGFHAYTEKILDPEAFSGYSIVAFAFDYQRNPSDVIHQNIVRSDLYPARKKHADEHAHMIKEYAKTNDIKGIFDLAQEDTEEYHSILRGVGVNVIRENMQKLISYLKLIRKDYWNAYIVTGGSNVYVAVESENADRLFSIENTFGSKKKMLRIVGGAWHRRPE
What is the function of this protein?
Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate.  Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.
What are the official names of this protein?
Mevalonate 3-kinase, M3K, ATP:(R)-mevalonate 3-phosphotransferase, ATP:(R)-MVA 3 phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: SYS_TOLAT
Sequence: MLDPKFLRSDIETAAERLALRGYKLDVATINALEEQRKVLQTRTQELQAERNARSKAIGEAKRLGQDVAPLMAQVGSLGSELEQCKKQQDEILEQLRQIALLVPNLPADTVPVGKDESENVEVRRWGTPRQFDFEIKDHVAVGEDNGGLDFATATKISGSRFVVLKGQIARMHRALAQFMLDLHTQQHGYTECYVPYLVNADSLLGTGQLPKFAEDLFHTAINGEGDEEGKVRKFSLIPTAEVPLTNIARDEIYDEKALPVKMTAHSPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQLVHPEKSWDALEEMVGHAEKVLQLLGLPYRVVSLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNCTDFQARRMQARVRGADSKPQLLHTLNGSGLAVGRTLVAVLENYQQADGRIEVPEVLRPYMSGLTHIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_BACCZ
Sequence: MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQMASKNANLKEYASFLGAGVYDHYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVSSNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDALLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: RSMH_MYCPA
Sequence: MKHSATSSEAHARATWPLPEPTLAYFPNARFVPSDRDLDAGAARPIRGGVAVVDDSPDFGHVPVLLERCVELLTPALTRRHPDGSGAVLLDATLGAGGHAERFLADLPGLRLIALDRDPSALEIARERLARFADRITLVHMRYDGIAAALTESGYAATESVDGILFDLGVSSMQLDRPERGFAYAQDAPLDMRMDPGSPLTAADILNTYDEAELADILHRYGEERFARRIAAQIVRRRAKEPFTSTADLVSLLYQAIPAPARRTGGHPAKRTFQALRIAVNDELDTLRRALPAALDALAVDGRIVVLAYQSLEDRIVKRLFAQAVASRTPVDLPVELPGHEPRFRALTHGAGRADAAEIERNPRSAAVRLRALQRTQAPQATGKGD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.