PharMolix/UniProtQA huggingface dataset:
Protein: YBEY_THET2
Sequence: MVEVVRNKRPPRGLVPRLRRALAALMEELGVGDKGVTVILTGDRRLRALKREWWGEDEATDVLSFPHYEPGDPFVPPHLGDIWISLDTARRQAEARGASLEEEVLVLAAHGLWHLLGHDHQKEEDWEGFRRVQERILAL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_YERPY
Sequence: MATINQLVRKPRSMKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQSRSKYGVKKPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SY61_DIPOM
Sequence: MKLTEAYHDALAALPATPPLPTAVANATEAAAGSEEGKQDGFSKVKVKEKFMNELNKIPLPPWALVAIAIVAIILGLTCCFCICKKCLLKKKNKKKGKEKGGKNAMTMKDVKEMGKSGKEQALKDEDEDAETGLTTDGKEEEKEDEKLGKLQFSLDYDFQNNQLIVGIIQAAELPALDVGGTSDPYVKVFVLPDKKKKYETKVHRKTLNPVFNESFIFKIPYSELGGKTLVMAVYDFDRFSKHDVIGEAKVPMNTVDFGHVTEEWRDLQGAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTAAELRHWSDMLANPRRPIAQWHTLQPEEEVDATLGMKK
What is the function of this protein?
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse.  It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
What are the official names of this protein?
Synaptotagmin-A, Synaptic vesicle protein O-p65-A.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Synapse. Note=Synaptic vesicles in neurons.
Protein: ETF2_MONPV
Sequence: MRYIVSPQLVLQVGKGQEVERALYLTPYDYIDEKSPIYYFLRSHLNIQRPEIVKRHILLTLRMTQLKGYLGNLLDIKDDIIIYSHKNNLEYSYVDNTIFNPFVYTQKKTLLKNDSFLYNVYSGACDFLVIWVARACDTSIPEFGSYEDVDNNIIKFETMLMEVFPQLDLDITVESKFNNIFRTNLKLTGLKKIIQRVQDLDINYKSLLSRYDEHFINMTGNHFILNDEQLNLSIWDLDSTLALSSDGDTVMINNVKLFTDLVSDIDTQMERIKGDITYKVHLATPINSRIKLDIETSFIFIETATNNILLSSDKKISIILAKNHISIKVKNHIPNIEKYFTFLVIAINAMFNSVQKSSDFTKVETVYWSRICQNTKNKNRKPIIINYLDPGMKKISNNFYRSDEKEVFINDNGIMFTCIDPLGKYNKVGFLNIFHDMRKYCIPCCFLHDQSHRSTFSSCVHQIDVEKKIVSPYILNFGKVVTESKMSFLPIIFDAFLNDGMTANMEQDNKRLKETSGYHIVRCCAGDDIVRLRTISDIIQFVNEDKNILIVNDMIYFPMNATDIGKKIHILIQEIVHEVMIVKKKESSDKIDFFPPNYKLLKDLFPKQTIQTPIHSDAGMVLTTDGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from early gene promoters.  Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase.  ETF heterodimer binds to early gene promoters.
What are the official names of this protein?
Early transcription factor 82 kDa subunit, ETF large subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae VETF large subunit family.
Protein: RL14_RHOBA
Sequence: MIQQESRLDVADNTGAREVMCIKVLGGSRRRFATVGDVIVCSVKSVIPGSEVKKKAVVRAVIVRVKQPTRRPDGSYIRFDSNAVVLVDKDRNPRGTRIFGAVARELRENNFMKIVSLANEVV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYA_LEUMM
Sequence: MKDLSSAEIRQMFLDFFASKGHEVVPSKNLIPQDDPTLLWINSGVATLKKYFDGTVVPNNPRITNSQKAIRTNDIENVGKTARHHTLFEMMGNFSIGDYFKEQAIPWAWELLTSPEWYGLDAEKLYVTVYPKDQEARKIWEEKTSLPDGHIYEVEDNFWDIGEGPSGPDSEIFFDRGSSFQDLPDDDPEMYPGGENERYLEIWNLVFSQFNHLPGLTDNSQYPELPHKNIDTGMGLERVVSVFQNGRTNFDTDLFLPIIRATEKLSNQFTYDDSQDSEVNTSFKVIADHIRAITFAIGDGALPSNEGRGYVIRRLLRRAVLHGQKLGIKGQFLTNLVPIVGDIMESYYPEVKANTAKIQKTVAAEEKRFNATLTGGLSLLNDVIKEAKKTGQTQISGADAFKLSDTYGFPLELTQEQAEDAGLTVDVDRYNDELQAQRVRARAARSNTKSMGVQNAVLTDLRVDSKYVGWSQTEVNHAEIVAIIGEDEQGVDALLDNADVDATVQVAFDVTPFYAEMGGQVPDFGDVLNTNGDVIAHVTDVQTAPNGQHIHTVDVISSFTLGDKVDLKVDMARHIAVSKNHTATHMLDQSLRNVLGGDVHQAGSLVEPEYLRFDFNNEGPVSSEDLDKIESMMNQEIAKNLPVTWLETDIESAKKLGAVAVFGEKYGDQVRVVSIGDFNKEFDGGTHANSTAELGLFKIVSESGIGAGVRRIEAVTGLQALSQYKAQEKALKEIATALKAQKLTDAPEKVYDLQADLRTVQRHAESLEAKLANATAGEIFNDVKTVNGHTYITAQLQVSGMDGLRQVADNWKENYPSDVLVLATVADEKVSLIVAAAPDANQSGIKAGELIKSIAPHIGGGGGGRPDMAQAGGKKPAGIPDAFAAVSAFLADK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZT23_CHIGU
Sequence: MNTSDPPAVLRIAAITLLCTASESVEQNPLIPFENAVLGSYAKMASEKRCDGWMAKCPDRDDCCETFHCTRFNARGN
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U14-theraphotoxin-Cg1c, U14-TRTX-Cg1c, Jingzhaotoxin-23, JZTX-23.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 65 (Jztx-21) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPA_MYCA9
Sequence: MTQPGRLTEVFDKCRAEERAALIGYLPNGYPDLDTSIELMTTLVRGGCDIIEVGIAYSDPMMDGPMIAAAAETALANGVRVADVFTTVRAITDAGGHAVVMSYWNPVLRYGVDAFARELAAAGGLGIITPDLIPDEADDWIAASDAHDLDRIFLVAPSSTPERLERTIGACRGFVYAASTMGVTGARDAVSNAAPALVSRVREVSDIAVGVGLGVRSGAQAAEIAAYADGVIVGSALVAAAPQGPAAVRSLAEELATGVRRA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TSAC_XYLFT
Sequence: MATTLTLSEAVTALQQGDVIAYPTEAVWGLGCDPRQETAVHTLLNIKQRASGKGLILVTAELNTLQDWLDLDTLSPERLHEVQASWPGPHTWVLPASTRAPHWITGHHNGLAVRISAHPLVSALCRAWNMALISTSANVAGQPPARRREDLDPSLLPHLAGIVDGPTGGLAQPTSIRDARSGHILRL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T17B1_CAEEL
Sequence: MEEYTREPCPYRIGDDIGSAFAMGLVGGSIFQAFGGYKNAAKGKKLVGMMREVRMRSTLTGVQFAAWGGMFSTIDCCLVAIRKKEDPINSIVSGGLTGALLAIRSGPKVMAGSAILGSVILAMIEGVGLVTTRWMGAMMDPTQPPPEALDDPRSLGQKSQAEPGLDQTRPFGIPTGLPNLS
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
What are the official names of this protein?
Probable mitochondrial import inner membrane translocase subunit tim-17B.1.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEF_SINMW
Sequence: MTKTDVSGLSQLGTKVDLPQNPEEAVLERVPSGHGGTDFVVRFTAPEFTSLCPMTGQPDFAHLVIDYVPDGWLVESKSLKLFLHSFRNHGAFHEDCTIDIAKRLVSLLSPKWLRIGAYWYPRGGIPIDVFWQTGSPPEGVWLPDQGVPTYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_ANOFW
Sequence: MDFETLLSYEWGVMMPEFIILGVAVALSLIDLFMPENRNRQLLGLFAFVGIAVSFVSLLSLWTSDVTSILGDTFRLDSFAKSFKALLLIGSALVLLLSIHYEPKERIAYRGEFYYLFLTALLGAMMMASSGDLITLFVGLELLSISSYILVAIRKKHTLANEAALKYVITGSIATAITLFGMSYIFGFTGSTNIKEIAVQLASTSDENHQYVLSLAFLLTFVGLSFKLASAPFHMWAPDVYQGATTPVVSFLSVVSKTAGFVIVLRVIVSVFAQTPAGSSASMLMTFAPYIAFLSGATMIIGNTIALRQRNVKRMLAYSSVAHAGYVLVAFASLSMFMFEAIWFYLLAYVFMTIGAFAILQVVSQHPDDEDISIFAGLYRRSPLMAIAMTIFLLSLAGIPGTAGFIGKMNIFLGAFVVEPAHYVLASIMVITTIISYVYYFGIFVQMFFRPVEHTHRLEWPPGVIAVVVICVIGTVLLGVFPNIAYDFLAPFQHFSDFLQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSFA_MYCTU
Sequence: MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT
What is the function of this protein?
Positive, redox-sensitive regulator of sigma-F (SigF) activity.  When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
What are the official names of this protein?
Anti-sigma-F factor antagonist RsfA, Anti-anti-sigma F factor RsfA.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor antagonist family.
Protein: SYT_STRPI
Sequence: MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKLIDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGFYYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIEEHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIYGTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRELERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPMNCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTPEQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAALDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADGEDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVAKKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQTVSVDNFVQAILADIANKSRVEK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_SPIMX
Sequence: MGVTKKPDLTDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVIFGTIACNVGLAVLEPSMIGEPANPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMAAVPAGLLTVPFLENVNKFQNPFRRPVATTVFLFGTVVALWLGIGAALPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AROB_SHEB5
Sequence: MKQIQVDLGVRSYPIYIGQNLMSDGETLSRYLLKKRILIVTNETVAPLYLKQIQETMASFGEVESVILPDGEQFKDLAHLDTIFTALLQQNYGRDSVLVALGGGVIGDMTGFAAACYQRGIDFIQIPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPQIVLIDTLCLHTLPAREFAAGMAEVIKYGIMWDADFFQWLEDNVTALKTLDAQALVYAISRCCEIKADVVSQDETEQGVRALLNLGHTFGHAIEAEMGYGNWLHGEAVSAGTVLAAQTAKALGLIDESIVCRIIQLLQAFDLPVRAPESMDFDSFIQHMRRDKKVLGGQIRLVLPTAIGRADVFSQVTESTLEQVIRCA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_BARHE
Sequence: MSKTYFTQDHEWLSVEGQVVTVGITDYAQEQLGDLVFIDLPQNGTKLSKGDAAAVVESVKAASDVYAPLDGEVVEINAALAESPELVNQKAETEGWLWKMTVQDETQLERLLDEAAYKELIG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SYP_VIBVY
Sequence: MRTSKYLLSTLKETPNDAEVVSHQLMLRAGMIRKLASGLYTWLPTGLRVLRKVENIVRQEIDNAGAIETLMPVVQPFELWEETGRSEKMGPELLRFTDRHVRPFVLSPTAEEVITALVRNEVSSYKQLPINLYQIQTKFRDERRPRFGVMRAREFCMMDAYSFDIDKAGLEKSYQAMHDAYCKAFDRMGLEYRPVLADSGAIGGNGSQEFHVLAESGEDLIAFSTESDYAANIEKAEAVAPAVERAAPTQEMTLVDTPNAKTIAELVEQHGISIEKTVKTLFVKASDAIEAPIVALIIRGDHELNEIKAENLAEVATPLEMATEEEMRELIGAGAGSLGPVGLKLPFIVDRSVAVMSDFGAGANIDGKHYFGINWGRDVELGQVADLRNVVEGDPSPCGKGTLMLKRGIEVGHIFQLGNVYSEAMNCGVLDSNGKNVILEMGCYGIGVSRVVAAAIEQNNDKYGIIWPDALAPFQVAIVPMNMHKSERVQEAAEKLYAELTAMGIEVLFDDRKERPGVMFSDMELIGIPHTIVIGDRSMDEGHFEYKNRRSGEKTPVAMADIVEYIKAQLE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_DESVV
Sequence: MTDAKRAQKLDLSLDHKVADMSLADYGRKDLQLSEREMPGLMELIRKYGGTKPLKGLKVTGSLHMTIQTAMLIRTLYELGADIRWASCNIFSTQDHAAAAIAASGMAKVFAWKGETLEDYWWCTEMALTWPDGSGPDLLVDDGGDATLFIHKGVEVENDPSLLKKAYDNKEFQIIMDRLALAYEQDPGRWQRVAAKVRGVSEETTTGVHRLYQLEQEGKLLFPAINVNDAVTKSKFDNLYGCRESLADGIKRATDVMVAGKVVVVAGYGDVGKGCAQSMRGFGARVLVTEIDPICALQAAMEGYEVTTMEEAVRTGDIFVTATGNCNVITGAHMEAMKDEAIVCNIGHFDNEIDMHYLENTEGCVCLNIKPQVDKWTLRSGRSIIVLAEGRLVNLGCATGHPSFVMSASFTNQTLAQIELATNPDLERKVYTLPKKLDEEVARLHLDRLGVKLTRLSKDQADYIGVSPEGPFKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POL_MCFF3
Sequence: RNTPGPHGLTPYEILYGAPPPLVNFHDPDMSELTNSPSLQAHLQALQTVQREIWRPLAEAYRDRLDQPVIPHPFRTGDSVWVRRHQTKNSEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAATTPPAGTASGPTWKVQRSQNPLKIRLTRGAP
What is the function of this protein?
Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.  This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA.  The first step in the integration process is 3' processing.  This step requires a complex comprising the viral genome, matrix protein and integrase.  This complex is called the pre-integration complex (PIC).  The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends.  In the second step that requires cell division, the PIC enters cell nucleus.  In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration.  The last step is viral DNA integration into host chromosome (By similarity).
What are the official names of this protein?
Gag-Pol polyprotein, Pr180gag-pol.
Protein: PPO_VITVI
Sequence: MASLPWSLTTSTAIANTTNISAFPPSPLFQRASHVPVARNRSRRFAPSKVSCNSANGDPNSDSTSDVRETSSGKLDRRNVLLGIGGLYGAAGGLGATKPLAFGAPIQAPDISKCGTATVPDGVTPTNCCPPVTTKIIDFQLPSSGSPMRTRPAAHLVSKEYLAKYKKAIELQKALPDDDPRSFKQQANVHCTYCQGAYDQVGYTDLELQVHASWLFLPFHRYYLYFNERILAKLIDDPTFALPYWAWDNPDGMYMPTIYASSPSSLYDEKRNAKHLPPTVIDLDYDGTEPTIPDDELKTDNLAIMYKQIVSGATTPKLFLGYPYRAGDAIDPGAGTLEHAPHNIVHKWTGLADKPSEDMGNFYTAGRDPIFFGHHANVDRMWNIWKTIGGKNRKDFTDTDWLDATFVFYDENKQLVKVKVSDCVDTSKLRYQYQDIPIPWLPKNTKAKAKTTTKSSKSGVAKAAELPKTTISSIGDFPKALNSVIRVEVPRPKKSRSKKEKEDEEEVLLIKGIELDRENFVKFDVYINDEDYSVSRPKNSEFAGSFVNVPHKHMKEMKTKTNLRFAINELLEDLGAEDDESVIVTIVPRAGGDDVTIGGIEIEFVSD
What is the function of this protein?
Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
What are the official names of this protein?
Polyphenol oxidase, chloroplastic, PPO, Catechol oxidase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: RS4_HALSA
Sequence: MALPGENTKFYETPNHPYQGERIAEESDLLSRYGLKNKEELWRAQSELRDYRREARRLLGQTGTVSGEEFVARLQRIGILSEEERLDDVLSLEVTDVLERRLQTVVYREGLANTMGQARQFVSHGHVTVDGSRVTEPSYTVPVSEENTLAFDETSDLTDELHPARAGAQE
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PFKA_LISW6
Sequence: MKRIAILTSGGDAPGMNAATRAVVRKAIYEGLEVYGINYGFLGLVNGDIRKLELGSVGDLLHRGGTFLYSARYPEFATEEGQLKGIEQLKKHQIDGLVVIGGDGSYHGAEALTKRGFPTIGIPGTIDNDISGTDFTIGFDTALNTVLDALDKIRDTATSHERTFIIEVMGRDAGDIALWSGLAGGAEAIIVPEESFNMDDVVDRLNKGRERGKKHSIIVVAEGVMSGNEFAKQLAEYGDYHARVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLENRGGLAVGIRENRIVENNIGEILKEKHTLDQKLFDLASILSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC23_ASPFU
Sequence: MDYEALKDQWSDVEDRDGIRLSWNTFPSTRMEASRLVVPIAAVYTPLKEKPDSPLLQYEPVTCKAPCRAVLNPYANVDVRARIWICPFCLMRNPLPPHYKDITENAIPPELHPQSTTIEYQLARPAPAPPIFVYVVDTCQEEDSLKALKDTLILSLSLLPPNALVGLITYGTMAQVHELGYTECAKSYVFRGSKEYAAKQVQEMLGLLAAGPRPNMPQQPTRPPVGPAARFLLPVQQAEFQITNVLEQLQRDPWPVANDKRPLRCTGVALSVAVGLLETSFQNAGGRIMVFTSGPATEGPGHVVGPELKEPMRSHHDIDRDNIKYYKKAVKFYDALAKRAANNGHVVDIFAGCLDQVGLLEMKNLANFTGGHMLLTDSFTSSQFKQSFVRVFDKDANDNLLMGFNASLEVLTTKELKVTGLIGHAVSLNKKSSSVGETECGIGNTCAWKMCGIDPSSSYGVYFEIANQGGPAAVQPGPQRGMMQFLTYYQHASGHYHLRVTTVARPLSGPAGDPTLAQSFDQEAAAVLMARIAVYKADVDDGPDVIRWVDRMLIRLCSRFADYRKDDPTSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVGDALVMIQPTLDSYSLEHEGSQPVLLDSASIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENLKALLEQPKEDARELIADRFPLPRFIVCDAGGSQARFLLSKLNPSTTHTTGGYGGGVTSQTIFTDDVSLQTFMDHLMKYVIRKCFTNVMNEANPPI
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VE7_HPV63
Sequence: MVGEQPNIGDLVSQEEPSVLDLNCYEDIPAEEEESEYPYAIVLPCGLCDQLLRLTCVSDLSTLTRLEELLLGSLRIVCPLCAIRHQRH
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.