PharMolix/UniProtQA huggingface dataset:
Protein: COX2_DROBF
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITILVGYLMFMLFFNSYINRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNDIEFDSYMIPTNELSNDGFRLLDVDNRIVLPMNSQIRILVTAADVIHSWTIPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNFFIKWIASKVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CPCE_MICDP
Sequence: MYRHLSEGIEDHREQEQKVENAANIQDDNQLTVEQAIANLQGEDLGLRVYAAWWLGRFRVDAPEAIDVLIQALEDEDDRTNVGGYPLRRNAARALGKLGEKRAVPALIKALECSDFYVREAAAQSLEMLGDSSSIPRLIELLNDQVPGTLPAPEPPQLTQPFDAIIEALGTLGASDAIPIIQEFLEHTVPRIQYAAARAMYQLTSESTAGYNQYGDRLVQALAQDDLQLRRAVLSDLGAIGYLPAAEAIADTLAENSLKLISLKGLLEKQFQPTKPEDLSPGAIKVMQLMDALL
What is the function of this protein?
Required for the chromophorylation of the CpcA gene product.
What are the official names of this protein?
Phycocyanobilin lyase subunit alpha, Phycocyanin operon protein CpcE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: DCHS_ACIBY
Sequence: MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYALNSFDFEKDVMAYFAEIFQIPFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTHYSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKESHPIIFANIGTTMTGAIDDIEMIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIPCGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCLKMAQYAVDRFQAVGIPAWRNPNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTRQIDSLIDDVIFDLQGASKRTVGF
What are the official names of this protein?
Histidine decarboxylase, HDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: IXTPA_PECAS
Sequence: MQKVVLATGNPGKVRELASLLADFGLDIVAQTELGVDSAEETGLTFIENAILKARHAAQITGLPAIADDSGLAVDALGGAPGIYSARYAGAEASDQQNLDKLLLTVKDVPDEQRRASFHCVLVYLRHAEDPTPIVCHGSWQGVLTHQSSGSGGFGYDPIFFVPELGKTAAELTREEKNAQSHRGQALRLLLDALRNA
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: CECC_DROER
Sequence: MNFNKIFVFVALILAISLGQSEAGWLKKLGKRIERIGQHTRDATIQGLGIAQQAANVAATARG
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin-C.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RVE4_ARATH
Sequence: MTSTNPVVAEVIPAETSTDATETTIATTEAGEAPEKKVRKAYTITKSRESWTEGEHDKFLEALQLFDRDWKKIEDFVGSKTVIQIRSHAQKYFLKVQKNGTLAHVPPPRPKRKAAHPYPQKASKNAQMSLHVSMSFPTQINNLPGYTPWDDDTSALLNIAVSGVIPPEDELDTLCGAEVDVGSNDMISETSPSASGIGSSSRTLSDSKGLRLAKQAPSMHGLPDFAEVYNFIGSVFDPDSKGRMKKLKEMDPINFETVLLLMRNLTVNLSNPDFEPTSEYVDAAEEGHEHLSS
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Protein REVEILLE 4, Myb transcription factor LHY/CCA1-like 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Actively translocating nucleo-cytoplasmic shuttle protein.
Protein: TGT_SHIBS
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: YKZS_BACSU
Sequence: MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHFRGIAQQGGDVIFQYLEQPRS
What are the official names of this protein?
Uncharacterized protein YkzS.
Protein: KAT8_HUMAN
Sequence: MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
What is the function of this protein?
Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126).  May influence the function of ATM (PubMed:15923642).  As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126).  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026).  That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026).  Can also acetylate TP53/p53 at 'Lys-120'.
What are the official names of this protein?
Histone acetyltransferase KAT8, Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST-1, hMOF.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RNH_CHLPM
Sequence: MEKKVTIYTDGACSGNPGPGGWGAMLMYGKTVREISGGAPATTNNRMELSAAIEALQALKEPCTVDLYSDSSYLVNAINEGWLKRWTANRWKTAAKKTVENIDLWQKILELTDRHRVRFHKVKGHSDNPYNNRCDELARLAVRKKP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y101_HAEIN
Sequence: MKLTPEMLTGKSREHLVNLPTTHSSNHFLQTQAVQAFQALQQSAAKNGFNLQPASSFRDFERQQLIWNSKFKGERKVHDDAGKALDLNQLDDWQKCQAILRWSALLRLVVIIGERKWIFLILIFCHEVNLYNWSLGNMKKAATSLN
What are the official names of this protein?
Uncharacterized protein HI_0101.
Protein: IHH_TRIHE
Sequence: VMNLWPGVRLRVTEGWDEDGHHSEESLHYEGRAVDITASDRDRNKYAMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Indian hedgehog protein, IHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Indian hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Indian hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: HISZ_AZOVD
Sequence: MATVDRWLLPDGIEEVLPPEAARIEVVRRQMLDLFQRWGYAFVVTPHIEFLESLLTGAGQDLDLRTLKVTDPLSGRLIGFRADITPQVARIDAHTLRREGPCRLCYAGSVLHAKPRALSTSRSPIQLGAELYGDASPASDVEVISLMLEVLEQVAVPDVHMDLGHVGIYRGLARAAGLSGEVEQRLFDALQRKAVDEVEVLTAVLPTAQAAMLRALAELCGGREVLDLAQACLVDAPAEVHAALDELIAIADSLGVRYPELPLYFDLSELRGYNYHTGVVFAAFVPGVGQSIAQGGRYDDIGADFGRARPATGFSTDLKTLVTLGQVAPAEPVVGIWAPDSHDVYLWQMVQRLRRQGERVVQALPGQRIDAARAGGCDRQLLLSDGQWQVVPLAL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SET2_YEAST
Sequence: MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALSSASTRMSSPPPSTSS
What is the function of this protein?
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3.  Involved in transcription elongation as well as in transcription repression.  The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-36 specific, Lysine N-methyltransferase 3, SET domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: GPR17_MOUSE
Sequence: MNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
What is the function of this protein?
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs).  Signals through G(i) and inhibition of adenylyl cyclase.  May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity).
What are the official names of this protein?
Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAX_I96A3
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVEPEDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPKEAKKQLKKDLKSQEQCAGSLTKAFRRTSPALRILEPMWMDLNRTATLRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: DTD_MYCTA
Sequence: MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLADEKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_DECAR
Sequence: MNWLLPEYLADALPAEAARIERLRRTVLDHFRSRGFELVMPPMLEYLESLLTGAGQDLKLRTFKLVDQLSGRTMGVRADITPQAARIDAHLLNHQGVTRLCYCGNVLHTLPATISAGREPLQIGAELYGYAGIAADLDVIRLMAGAFDQIKLPIRRIDLGHVGIFRALAEAAGLPQEAEDSVLSLLQTKDVPGLIEACANVPSPYREALQRLPQLYGGADVLERAAAELPPLPAITAALEGLRHLLVGAPELPFSIDLSDLRGYHYHNGVVFAAYCDGYPAAIALGGRYDGAGKAFGRARPATGFSMDLREVARLVTVGKSNGAILAPHAGQNKHLAAHIAALREQGEIVVELLHGETACEGPLCDRKLALVGEHWIIEAIQED
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_GLAP5
Sequence: MVSQNYLGVMSGTSLDGVDLALVDFSQTPKLIAADFTPMPDTLRVALSQLVKKGETSLQALGELDHQLALLYADSIQRFLAKHQLNADDIVAVGCHGQTVWHSPKGQYPFTMQIGDMNLLAARTGITTVGDFRRRDMAFGGQGAPLVPAFHQAVFSSPERLTVVLNIGGISNISVLNPNQQTIGYDVGAGNTLLDIWIEKHLGKRYDANGEWARTGKIHSALLALLLDEPFFQLPPPKSTGRELFNLEWLEHKLTQIKPLPAEDVQATLVEFTVQSIVQALRQIENPQAYPCVLLVCGGGAKNPLIMERLQTHLTDWQVSTTTEYGLDVDYVEAAAFAWLAYQRIHNLPANLPSVTGATQAVSLGAIFPNI
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: DLGP2_MOUSE
Sequence: MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEGGDLAQPGLSFPGPAEEDIDQQYSWSPTQHFNEERYSPAPRNMKGLTGSRNQPQLCAGHTCGLSPPDDCEHPHDHMHHGSDVRQPYLLSPAESCPMDHHRCSPRSSVHSECMMMPVMLGDHVSSSTFPRMHYSSHYDTRDDCAMSHTSTKVNRIPANLLDQFEKQLPLHRDGFHTLQYQRASAATEQRNESPGRIRHLVHSVQKLFTKSHSLEGSSKSNINGTKSDSRVDDHHQSHLSKHSKRSKSKERKPESKHKSGMSSWWSSDDNLDSDSTYRTPSVAHRHHMDHIPHCYPEALQSPFGDLSLKTSKSNNDVKCSACEGLALTPDTRYMKRSSWSTLTVSQAKEAYRKSSLNLDKPLVHPEIKPSLRPCHYLQVPQDDWGAYPTGGKEEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPTVAIRPEPLLKPIIQRPLGDHQTQSYLQAATEVPVGHSLNPSINYNSPKFRSRNQSYMRAVSTLSQASCVSQMSEAEVNGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPVMTSSNMTSTIRSTAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGGLYNSMDSLDSNKAMNLALETAAAQRHAADTQSSSTRSIDKAVLASKAEELLKSRCSSIGVQDSEFPDHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHVSMEDKGLQFGSSFQRHSEPSTPTQYGALRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPSLDTVETGRMSPCRRDGSWFLKLLHTETKRMEGWCKEMEREAEENDLLEDILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSVEDVSMKFDELHQLKLNDWKIIESPERKEERKIPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAAKRAASFRQNSATERADSIEIYIPEAQTRL
What is the function of this protein?
May play a role in the molecular organization of synapses and neuronal cell signaling.  Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton.  May induce enrichment of PSD-95/SAP90 at the plasma membrane.
What are the official names of this protein?
Disks large-associated protein 2, DAP-2, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, SAPAP2.
What is the protein family that this protein belongs to?
Belongs to the SAPAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Postsynaptic density. Synapse. Note=Postsynaptic density of neuronal cells.
Protein: GRA5_GIBZE
Sequence: MHLDHKLPWKTIASHFTLARDGSSPNYNLIALGLSTQDAALGHFSRIFIATIEEFSNTETSKINLNQVDGKLFSDDVLNFPEHHFGLGPHDTNSALNNPLDAKHQELKYWKGRASTASEYGTSPEYSASYSTADGDLADAAKMLVITAAVSDNQAIRREALSALCQLSAHVPMSDLRGLSWGHGFGLSLVASEALKLYMLLNLIEAVQSRGAQQVSLLRVKILLCALGNYSLQNYDFPAQNIPHRAFWHSLGITESWADRQADGVRESDEPVVDPLGLGDDEIHQEARINLKKYLKDCFAILYVYDVFLKQIASEEERKEFWSYEINRVILYL
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
Gramillins biosynthetic cluster protein FGSG_00039.
Protein: RIMP_CLOBB
Sequence: MRKDMLLEKVEVLVKPIVEELSYELYYLEYVKENGEYYLRIYIDKEEDSISLNDCEKVSRRVSEILDVEDPIEDSYYLEVSSPGLNRGLYKEEHFKKFIGREVLVRFNGSLEGMKKIQGILKEADNEFITVQGEKKLKIPTEKIKGANLEGEI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_ECO81
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PSIE_ECO55
Sequence: MTSLSRPRVEFISTILQTVLNLGLLCLGLILVVFLGKETVHLADVLFAPEQTSKYELVEGLVVYFLYFEFIALIVKYFQSGFHFPLRYFVYIGITAIVRLIIVDHKSPLDVLIYSAAILLLVITLWLCNSKRLKRE
What are the official names of this protein?
Protein PsiE.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUSK4_DROME
Sequence: MEQSQSQRQAWPSSSAGGGKAQDSGVLTREDFDGGPVSIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRMGCKIDPNCQRYKIHRLRLAGEQMRKAKILPQSFHSVVRPDPDITRENPEPIVFRCRRCRRVLASKSHVLEHKPRDRPPQEVVPKEKEEVAAAKLPAQSHDQAENHHGARMLEQLSERIRQSSLGSPGHESTPNYCRSILFVEPIAWMHRIMLNTQGRLYCPKCEQKLGNFSWINACKCPCGETMTPAFYLIPSKVELSKAVQNVQTTV
What is the function of this protein?
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues.  May suppress bsk/JNK activation during the immune response.
What are the official names of this protein?
Dual specificity protein phosphatase MPK-4.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly found in the nucleus.