PharMolix/UniProtQA huggingface dataset:
Protein: Y1265_LACH4
Sequence: MQRLWVTGYRSYELNVFGDKDPKIIIIKYALKNYFKGLLENDQLDWIITGANLGVEQWTAEVGLELGQKYPLRTSIMIPYEKFADRWNENNQTKFLNLKERVDFFASTSNLPYQNPVQLRNYQNFMLQHTDRALMVYDTEHPGKSKYDYNLIQKYQKAEEYPLDLIDFYDLQDVAEEYQEAHQRNYFSE
What are the official names of this protein?
UPF0398 protein lhv_1265.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: ARPR_PSEPU
Sequence: MVRRTKEEAQETRAQIIEAAERAFYKRGVARTTLADIAELAGVTRGAIYWHFNNKAELVQALLDSLHETHDHLARASESEDELDPLGCMRKLLLQVFNELVLDARTRRINEILHHKCEFTDDMCEIRQQRQSAVLDCHKGITLALANAVRRGQLPGELDVERAAVAMFAYVDGLIGRWLLLPDSVDLLGDVEKWVDTGLDMLRLSPALRK
What is the function of this protein?
Probable regulatory protein for the antibiotic efflux pump arpABC operon.  May function as a repressor (By similarity).
What are the official names of this protein?
Probable HTH-type transcriptional regulator ArpR, Antibiotic efflux pump ArpABC operon regulator.
Protein: TSAD_MESFL
Sequence: MKILAIESSCDEFSISIIDDGKILTNIISSQIDQHVNFGGVVPELAARLHLENISWVIKSALESSNTKIEEIDHVAYTEKPGLIGSLIIGKLVAETIASYIDKPLMPLHHIEGHIYGASIENEFVYPVLAMVVSGGHTQIEIVNSPNEFEVIGATLDDAIGECYDKVARVMGLGYPGGPKIDKLAQKGNKEAFIFPISKNDDSYDFSYSGLKTAVINIIHNLTQKGEEIPVADIAASFQYAATKIVEKKLEKAIIQFKPKTLTVAGGVSANSEIRNIIMSLGKKYNITNTFVPKMEYCTDNAAMIAKLAYEKLKSSN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN2_STAA8
Sequence: MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEQGPVTQVFENPQHTVTKRFVKDDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ALDOL_ORYSJ
Sequence: MSDCNSGGGERRPNARATDAPPVRAPSGGAFRCRGCGACVILIAKYNPKTDEVTEFNASSCLTLLYSIHFCSIITTEGLGNTKDGFHAIQKRMSGFHASQCGFCTPGMCMSIFSSLVNADKSKKPDPPKGFSKLSVSEAERSFSGNMCRCTGYRPIVDACKSFASDVDLEDLGLNIFWKKGDKHPDPTKLPSYTLGGGICTFPDFLKSEIKSSIDFNDASISSPREGWYCPKNIKQYYKLVNSGLFSESSVKVVVGNTSTGVYKDQDLYDKYIDIAGIPELSAIVRKDKGIEIGAATSISRTIEILNQESESTSSPNGSVVFRKLAEHMSKVASPFVRNTASIGGNIILAHKYPFRSDIATILLGAAATVNLQVSSKTLHVTLEQFLEQPPLGHNTLLLSIFIPHWASDCKKEHTLVFETYRAAPRPLGNAVSYVNSAFLGHVSLDKSSGDNILSNLHLAFGAYGTEHAIRARKVEEYLTGKILSASVVLEAIRLLRETIVPVEGTTHPEYRVSVAVGFLFSFLSPLCKGVIEPGKTLSISEDLVHTDNVHNMPLSSRRETLSGDEYKPVGDPIKKYKVELQASGEAIYVDDIPAPKNCLYGEFIYSTQPLANVKSIKFKPSLASKKILTVVSAKDIPTGGRNIGSTFLFGDEEPLFGDPIAEFAGQALGVVIAETQRYADMAAKQAVVEYTTDGLKAPILTVEQAVQNNSYFQVPPERAPKQVGDFSKGMAEADHKIMSEEVKLASQYYFYMETQTALAIPDEDNTMTVYSSSQFPELAQNVISKCLGIPFNNVRVITRRAGGGFGGKAVRSLHIATAAALCAHTLRRPVRMYLNRNTDMIMVGGRHPMKARYSVGFKSDGKITALHLDLLINAGISADASPVIPGTIISGLKKYNWGALSFDVKLCKTNNTSKSVMRAPGDTQGSFIAEAIIEHVAAILSLDANTVRQKNFHTYDSLVLFYPDSAGESSTYTLHSIFDRLASTSRYLQRVESIKKFNSTNKWRKRGISSVPLIFKVEPRPAPGRVSVLNDGSIVVEVGGVELGQGLWTKVQQMTAFALGQLWPKGCEGLLDRIRVLQSDTLNLIQGGLTAGSTTSESSCAATLQACNMLIERLKPVMERLQLQSDTVSWDTLISQASQENINLSASAYWVPEQDSNFYLNYGAGTSEVEVDLLTGAITIIRSDLIYDCGKSLNPAVDLGQIEGSFIQGIGFFIYEEHQTNSDGLVISNSTWDYKIPSVDTIPKQFNAEVLNTGYHKHRVLSSKASGEPAVVLGASVHCAVREAIRAARIEFAGNNGSGSSLLTFQLDVPAPMTVVKELCGLDIVEKYLEDLSNRGAASGN
What are the official names of this protein?
Putative aldehyde oxidase-like protein.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
Protein: RS3_AGRRK
Sequence: MGQKINPIGFRLGINRTWDSRWFADNAEYGQLLHEDLKMRKFVMDELKQAGISKVVIERPHKKCRVTIHSARPGLIIGKKGADIDKLRKKLSDMTNSETHLNIVEVRKPEIDAVLVAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIKITCGGRLGGAEIARTEWYREGRVPLHTLRADIDYGTAEAETAFGICGIKVWIFKGEILEHDPMASERRALEGDAQGPASRDRDRDRRRDNA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: VPRT_ASFB7
Sequence: MSILEKITSSPSECAEHLTNKDSCLSKKIQKELTSFLEKKETLGCDSESCVITHPAVKAYAQQKGLDLSKELETRFKAPGPRNNTGLLTNFNIDETLQRWAIKYTKFFNCPFSMMDFERVHYKFNQVDMVKVYKGEELQYVEGKVVKRPCNTFGCVLNTDFSTGTGKHWVAIFVDMRGDCWSIEYFNSAGNSPPGPVIRWMERVKQQLLKIHHTVKTLAVTNIRHQRSQTECGPYSLFYIRARLDNVSYAHFISARITDEDMYKFRTHLFRIA
What is the function of this protein?
Cysteine protease that plays several role during infection including processing of the structural polyprotein or inhibition of the host immune response.  Catalyzes the maturation of the pp220 and pp62 polyprotein precursors into core-shell proteins (PubMed:12438573).  Plays a role in the disruption of host pyroptosis via specific cleavage of gasdermin D/GSDMD (PubMed:34890644).  In addition, strongly decreases the host cGAS-STING signaling by targeting IKBKE via its enzymatic activity (PubMed:35437104).  Impairs also host FOXJ1-mediated antiviral effect via degradation of FOXJ1 (PubMed:35513267).
What are the official names of this protein?
Cysteine protease S273R, pS273R.
What is the protein family that this protein belongs to?
Belongs to the peptidase C63 family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Found in the perinuclear cytoplasmic viral factories during assembly.
Protein: LPXK_OLEA2
Sequence: MSSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPVVQWLLQWAAVHGLHAVVLTRGYKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVVDPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLLKKDDLHAEWGRVLPAGSWREGPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQLPAGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCTPKDAVKLTAPCGVPVWTLSLETNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MDH_DEIRA
Sequence: MTMKQPVRVAVTGAAGQIGYSLLFRIAAGDMLGQDQPVILQLLEITPALKALNGVVMELRDGAFPLLADVITSDDPMVAFKDADYALLVGAMPRKAGMERGDLLGANGGIFKPQGEALGAVASRNVKVLVVGNPANTNALIAQQNAPDLDPKCFTAMVRLDHNRALSQLAEKTGAAVSDIKNVTIWGNHSSTQYPDLSQATVNGKPALEQVDRTWYENDYIPTVAKRGAAIIEARGASSAASAASAAIDHMHDWALGTKDGEWVSMGIPSDGSYGIPEGLIYGFPVRVKDGKYEIVQGLDVSDFSRGKMDATAQELEEERDEVRKLGLVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: FMT_PSECP
Sequence: MRVLFAGTPAVAVPSLDALVEAGFDVVAVLTRPDAPIGRKRVLTPSPVAARAAELGLDVIYAAKVDDAAIEQISAAAPDVAAIVAYGGLVPPAALAIPRHGWINLHFSLLPAWRGAAPVQRSVMAGDDVTGAVTFQLEKGLDTGPVFGTLTEAVGPEDTSGQLLERLSHSGAVLLAQTLSAIETGKASAVPQAGDVSLAPKLTLEDGHLNWHHPALAIGRQARGATPEPGAWTLLDGQRVKLDPVRLRPDVEDLAPGALAFHGKSVLVGTGSHAVELTRIQPAGKKMMAAPDWARGIGSLEGVVFE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: ANXC1_CRYNH
Sequence: MYGQQNNYGAPPPQQWGQAPPQGYQPGYQNGPPAVNYGAHPSQQQQWGAPPGPPQHQPYGAPPVNQYGAPPQHQQGYGGHSPQPPFGAPSPAPAGYGAPPTAPQGQYGAPSPYPQQPPQQGFGGPQQGYGSQPQGQSPMMYLGVPIPAPPPAVPVSTLAGYDARFDAERIRKATKGFGTDERTIIDTLSPLDAFQMDVLSRTYEQTVGRSLKSTLEKELSSWLEYTLVLLSLGPLGGDVYLLHRACNGMGTHEDLLNEVLLGRTNQEIFLLKEAYRRTYNQDLVQIVQGELSMKTERMFNMALSGQRDESPYLNHQLVQQDVETLYRAGPGKIGTDEIAICGILISRSKEHLKAIAQAFPARHRVSLSQMIHSEFSGHMRDALFFIARGVEADGDGVVRDCELLHAAMAGMGTKDERMIYRLVRNHWNRPRFNAIKNQYQVLYRNSLRRAVEGETTGKYEKALVGIIEQN
What is the function of this protein?
Does not appear to play a major role in virulence (PubMed:31140968).  May play a role in titan cell formation (PubMed:31140968).
What are the official names of this protein?
Annexin C1.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
Protein: MQO_GLUOX
Sequence: MPSLSSLCPDIVLIGAGIMSSTLAALLRELDPSLSMVMFETLSDCGQESSYAWNNAGTGHAGNCELNYTPQRADGSVDISKALAVNTEFDLSRQLWAHWVREGRIADPAAFVQPCPHISLVWGAENVAFLKARYEAMVAHHCFADMEYTDDPAVIAQWAPLAMAGRDTTQPVAATRIREGTDVNFGALTHALTASLKTDRSVSIHYNHRVTDLTRTEDGRWRVTATDTESGHAITVLTRFVFIGAGGNALPLLQKSGIPEATHYAGFPVSGLWLRCTDPAITRQHHAKVYGKAPVGSPPMSVPHLDTRVIDGKSCLLFGPYAGFSTKFLKSGSWTDYFRSLTPKNIIPALTAGKDNLGLLDYLVKQVIQTNEARFQALLDFYPTARPEDWSKVVAGQRVQIIRPDSGLHGKLRFGTELVKNADRSLVAVLGASPGASIAASVALQVVQGCFPERLVEGDWLPRLRQVFPAYGVDLTQDAAACATLRRDTAQVLGIASEAG
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: WNT5A_ALOVU
Sequence: SGSCSLKTCWLQLADFRKVGNALKEKYDSATAMKLNGRGKLVQVNSRFNTPTTLDLVYVDQSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCALMCCGRGYDQFKTVRTERCHCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Can activate or inhibit canonical Wnt signaling, depending on receptor context.  Required during embryogenesis for extension of the primary anterior-posterior axis.
What are the official names of this protein?
Protein Wnt-5a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: VSP1_OPHHA
Sequence: MALIRVLASLLILQLSYAVTPFDRIIGGFECNEYEHRSLVHLYNSSGFFCSGTLLNHEWVLTAAHCNRDDIQIKLGVHNVSVNYEDEQIRVPKEKLCCHSTNNCTQLGQDIMLIRLNSSVNYSEHIAPLSLPSNRPSMGSVCRVMGWGLLTSPEVTFPKVPHCVDINILHIQVCQAAYPSMSENYLLCAGVLEGGKDSCKGDSGGPLICNREIQGIVSWGGFPCAQLLEPGVYTKVFDYIDWIEGIIAGNTSVTCPSDNF
What is the function of this protein?
Snake venom serine protease that possesses potent fibrinogenolytic (on both alpha- (FGA) and beta-chains (FGB)) and amidolytic activities.  Selectively cleaves Arg-|-Xaa or Lys-|-Xaa bonds.
What are the official names of this protein?
Alpha- and beta-fibrinogenase OhS1, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM3_CALMQ
Sequence: MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFEREVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVSEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHVPLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVARLLKYS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL5_BACMK
Sequence: MNRLKEKFQKEITPALMSKFNYKSVMEVPKIEKIVINTGVGDAVSNSKALDNAVEELTQIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGQQMYEFFDKLVSVSLPRVRDFRGVSKKSFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTAKTDEEARELLTQFGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: HEM4_MOUSE
Sequence: MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYYEDQGIPASITFFSPSGLKYSLEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVLKPNHCC
What is the function of this protein?
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins.  Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity).
What are the official names of this protein?
Uroporphyrinogen-III synthase, UROIIIS, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen-III synthase family.
Protein: DER_STUS1
Sequence: MVPVIALVGRPNVGKSTLFNRLTKSRDAIVAEYAGLTRDRQYGEAKWQGRTYIVIDTGGISGDEEGIDAKMAEQSLQAIEEADAVLFMVDSRAGLTAADQMIGEHLRKRNKRCFLVANKVDSVDPDIARAEFSPLGLGDALPIAAAHGRGISHMLEQALGIFPKDNADENAEGEEGGELAEGEEVVAEGQEPKRIPGPSEKEGIKIAIIGRPNVGKSTLVNRMLGEERVIVYDQAGTTRDSIYIPFERDEEKYTLIDTAGVRRRGKIFEAVEKFSVVKTLQAIQDANVVIFVMDAREGVVEHDLNLLGFVLETGRALVIALNKWDGMEQGEKDYVKTELERRLFFVDYADIHFISAKHGTGVGHLYKSVQAAFKSAITRWPTSRLTQILEDAVREHQPPMVNSRRIKLRYAHLGGANPPLIVIHGNQVDAVPKSYTRYLENTYRRVLKLVGTPIRIEYKGGDNPYEGKKNTLTDRQVNKKRRLMSHHKKAEKKRRDKKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: UREG1_BRUSU
Sequence: MTQKNGPLRVGIGGPVGSGKTTLTEKLCKAMRDKYSVAVITNDIYTQEDALILARRQALSEDRIIGVETGGCPHTAIREDASINLQAVVEMTRRFPDLDVVFIESGGDNLAATFSPDLADLTLYVISVCQGEEIPRKGGPGITRSDFLVINKSDLAPYVHVDLEVMEADAMRMRAKRPFGFTDLHRGKGVQEIIDFIVENGGLEPRSN
What is the function of this protein?
Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
What are the official names of this protein?
Urease accessory protein UreG 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_CHESB
Sequence: MIQKNWQELIKPSKIEFTSKGRTQTNLVAEPLERGFGLTLGNALRRVLLSSLRGAAVTAVQIDGVLHEFSSIAGVREDVTDIVLNIKEIAIRMEGDGPKRMVLRKQGPGAVTAGDIQTVGDVEILNPEHVICTLDQGAEIRMEFTVNTGKGYVPADRNRAEDAPIGLIPVDSLYSPVKKVSYKVENTREGQVLDYDKLTMTIETDGSVTGEDAVAFAARILQDQLGLFVNFEEPQKEVPAEQVTELAFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLASMGLHLGMEVPDWPPDNIEELAKRYEDQY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y3875_STRCO
Sequence: MSADAPEPGPGQSPGERASGGPEPSGVDLARVALRAAREAARARGDAAQQKKQARRGGLRSGARADGRDPMALGSAINRLITERGWETPAAVGGVMGRWPEIVGADVAKHCVPERYDEDERVLVVRCDSTAWATNLRLLAPTLVARLNEDLGHGSVRMIKVLGPGGPGGPGRRYGPLRAPGSQGPGDTYG
What are the official names of this protein?
UPF0232 protein SCO3875.
What is the protein family that this protein belongs to?
Belongs to the UPF0232 family.
Protein: GRB10_HUMAN
Sequence: MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
What is the function of this protein?
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways.  Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.  The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation.  Delays and reduces AKT1 phosphorylation in response to insulin stimulation.  Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.  Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways.  May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.  Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6.  Positive regulator of the KDR/VEGFR-2 signaling pathway.  May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
What are the official names of this protein?
Growth factor receptor-bound protein 10, GRB10 adapter protein, Insulin receptor-binding protein Grb-IR.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity).
Protein: MSRB1_ARATH
Sequence: MASSTRLTIIQSSFVSARTRLNYVSKTNHSGFACRSLSKPRNLSLSVYSMGSSSSSPKPDNVQEAEKNEFASLSENEWKKRLTPEQYYITRQKGTERAFTGEYWNSKTPGVYNCVCCDTPLFDSSTKFDSGTGWPSYYQPIGNNVKTKLDLSIIFMPRQEVVCAVCNAHLGHVFDDGPRPTGKRYCLNSAALKLNALEKTRD
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Specifically reduces the MetSO R-enantiomer.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  May play an essential function in association with MSRB2 in maintaining vegetative growth during environmental constraints, through the preservation of photosynthetic antennae.  MSRB1 and MSRB2 account for most of the leaf peptide MSR capacity.
What are the official names of this protein?
Peptide methionine sulfoxide reductase B1, chloroplastic, AtMSRB1, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ILVC_BARQU
Sequence: MHVYYDHDANVNLIKGKKVAIVGYGSQGHAHALNLKDSGVQDVRIALHSRSATAKKAIADGFEVVRVAEAAKWADLIMMATPDELQADIYKEHMHDDLRDGAVIAFAHGLSIHFGLIEPKKTVDVVMIAPKGPGHKVRNEYQRGCGVPCLIAVAQDVSGHAHDIALSYACGIGGGRAGVMETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLLYEGGIANMNYSISNTAEWGEYISGPRVITDKTKAEMRRILKDIQTGKFTSNWIQECKAGAIHFKSMRRLNDSHPIEEVGKKLRSMMPWIKSNALVDKKRN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PG044_MONPV
Sequence: METKSDYEDAVFYFVDDDEICSRDSIIDLIDEYITWRNHVIVFNKDITSCGRLYKELIKFDDVAIRYYGIDKINEIVEAMSEGDHYINLTEVHDQESLFATIGICAKITEHWGYKKISESKFQSLGNITDLMTDDNINILILFLEKKMN
What is the function of this protein?
Virulence factor that affects the acute immune response to infection.  Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation.  Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.
What are the official names of this protein?
Protein K7.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG044 family.
Protein: RS8_THEKO
Sequence: MTLLDPLANALSHITNSERVGKKEVYIKPASKLIGEVLRVMLENGYIGEFELIDDGRAGIYRVQLIGKINKAGAIKPRFPVKARDYEKWEKRFLPAFEFGILIVSTSQGVMTHKEALEKGIGGRLIAYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: DAPEL_BACC4
Sequence: MTVSKFVQIRRDLHRIPEIGFKEWKTQQYILDYIGTLSHEFVEVKTWKTGVIVKVNGKNPEKIIGYRADIDGLPITEETGYEFASIHEGMMHACGHDVHTTIGLGLLTKAVSERIDDDLVFLFQPAEEGPGGALPMLESEELKEWKPNIILGLHIAPEYAVGTIATKEGLLFANTSELYIDLKGKGGHAAYPHTANDMIVAASHLVTQLQSVISRNVNPLDSAVITIGKITGGTVQNIIAEKSRLEGTIRTLSVESMKRVKSRIESIVAGIEASFQCEAIIDYGAMYHQVYNHEELTREFMEFVHKQTDMNVITCTEAMTGEDFGYMLREIPGFMFWLGVNSEYGLHHAKLKPDEEVIEKAITFLSQYVKWKGNRK
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: PPIB_STRAT
Sequence: MSTVELNTSAGRIVLELNDAEAPKTVENFLAYVRSGHYDGTIFHRVISDFMIQGGGFTPDMQQKSTLAPIQNEADNGLRNDNYTVAMARTNDPHSATAQFFINVKDNAFLNHTSKTPNGWGYAVFGRVTEGQDVVDAIKGVKTGSSRGHQDVPVQPVVIESAKILG
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase cyp18, PPIase cyp18, SanCyp18, Rotamase cyp18.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.