PharMolix/UniProtQA huggingface dataset:
Protein: TNIK_MOUSE
Sequence: MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERSRVRANSKSEGSPVLPHEPSKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGNNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGAEYGIGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
What is the function of this protein?
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway.  Recruited to promoters of Wnt target genes and required to activate their expression.  May act by phosphorylating TCF4/TCF7L2.  Appears to act upstream of the JUN N-terminal pathway.  May play a role in the response to environmental stress.  Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.  More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading (By similarity).
What are the official names of this protein?
Traf2 and NCK-interacting protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Protein: MURG_AGRVS
Sequence: MTKGLILLAAGGTGGHLFPAEALAHELRARGYSVHLVTDSRAERYAGKFPADAIHVVPSATIGSKNPVAIAKALLTLWRGYRAARSLIAGLKPLVVIGFGGYPTIPPLLAARALGVATVIHEQNAVMGRANRFLAPRVKAIAGGFLPAGGAYADKTVVTGNPVRPAVLAASETDYQPSGDGDPFELVVFGGSQGAQHFSNAVPSAICILDDVLRARLRITQQARPEDADRVKALYEKLKVPASVSPFFGDMAERIATSQMVISRSGASTVSELGVIGRPAVLVPYPYALDHDQAANAAAISGQGGAVVVPQSDLTPEKLSALLKDWMTSPAKLAQMAASARSAGQPEAAGLLADLVQTIAEGKNLKTLKDVKA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FOLD_CAMJ8
Sequence: MTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RUVC_MYCUA
Sequence: MRVMGVDPGLTRCGLSLIESGQGRQLTALDVDVVRTPSDAPLSSRLLAINEAVEHWLETHRPDVVAIERVFSQQNVKTVMGTAQAGGVVALAAAKRGVEVHFHTPSEVKAAVTGNGTADKAQVTAMVTRILALQTKPTPADAADALALAICHCWRAPMIAQMAKAHALAEQQRRSYTAKLKAAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RS8_FINM2
Sequence: MMTDPIADMLTRIRNAVNAKHKVVEVPASNIKKSIAQILLDEGFIDGFNVTEDGKQGIITIDLKYGPNEEKVISGIKRISKPGLRVYARANEVPKVLGGLGIAIVSTSKGLVTDKVARKEGIGGEVICYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PYRB_BACCR
Sequence: MLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDVRHSRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVEREKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TXA2_LATTR
Sequence: MLKLICIAFLVTVLTLVAGQDSLDPAEFGCADDVNQAELLKNNDICLQCEDLHKEGVVFSLCKTNCFTTEYFQHCVKDLEEAKKEPPE
What is the function of this protein?
May increase the toxicity of alpha-latrotoxin and/or other venom components.  Is non-toxic to mice and to the cockroach Periplaneta americana.
What are the official names of this protein?
Alpha-latrotoxin-associated low molecular weight protein-2, Alpha-latrotoxin-associated LMWP2, Latrodectin-2.
What is the protein family that this protein belongs to?
Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRM5_DICDI
Sequence: MNVLNKEVFNQTKKVLGLIVSNKLVNGFSKQFKSYMFQSPKFKPIVSTDNDDKKMIYLCDTLKKETDIPDQLKTFIKENDIKVIEKDISLNYNNFSYEQVLKTLLPKDVGIPFSFERIGHIIHVNLKDEQLPFKYIIGQAILDKNIQVKTVLNKVGEIDTVFRTFKIEILAGEPDLVAEIKENECIFRFNFEEVYWNSRLQYEHMELVNTFKKEDIICDMFAGVGPFALPAAKIKKCKVYANDLNPSSVKYMKENAKTNRLESKVEISNLDARDFVKSLVEKSIPFTHVVMNLPSTSIEFLDVFRDIFLNSTIPPPIPPPIINCYTFTKLDESSDLIKDTIKNVENVIGAKVPSDYVCYEVRDVAPKKSMMRITFRMPTILPYVGSLTTASTTTTPTTSNTNTSTTTSTTSTSTTTTESTNTNNSANNVEDKNNKKRNSTEDSNETNETDSIDTNKKLKN
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: RS7_DICNV
Sequence: MSRRVRAPIRHILPDPKFGNVMVAKFVNMLMVDGKKSVAEKVVYQALETAGKKKNMEAISLLEEALDKVRPAVEVKSRRVGGATYQVPVEVRPVRQNALAMRWLIEAARNRNEKSMAERLANEFLEAVEERGAAVKKRDETHRMAEANKAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Z585A_HUMAN
Sequence: MPANWTSPQKSSALAPEDHGSSYEGSVSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVGYQVPEAEVVMLEQGKEPWALQGERPRQSCPGEKLWDHNQCRKILSYKQVSSQPQKMYPGEKAYECAKFEKIFTQKSQLKVHLKVLAGEKLYVCIECGKAFVQKPEFIIHQKTHMREKPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQCGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYECSNCGKSFISKSQLQVHQRVHTRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPHKCGHCGKLFTSKSQLHVHKRIHTGEKPYMCNKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELITHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCGICGKGFVQKSVFSVHQSSHA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 585A.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEC_PHALU
Sequence: MASSVLLVLSLFLVLLLTQASAELFFNFQTFNAANLILQGNAVSSKGHLLLTNVTHNGEPSVASSGRALYSAPIQIRDSTGNASSTPTSHSYTLQQIFQNVTDDPAWLFALVPVDSQPKKKGRLLGLFNKSENDINALTVAVEFDTCHNLDWDKNSIAVNLGIGSVPWNFRDYDGQNADVLITYDSSTKFLAVSLFYPITGKRNNVSANVELEKVLDDWVSVGFSATSGAYETHDVLSSSFASKLSSLDECPTGENLLNKIL
What is the function of this protein?
This metalloglycoprotein, containing Ca(2+), Mn(2+), binds glycoconjugates containing terminal non-reducing alpha-D-GalNAc residues.
What are the official names of this protein?
Lectin, LBL.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: TYSY_STRA3
Sequence: MTKADLLFKDNITKIMSEGVFSEQARPRYKNGEMANSKYITGAFAEYDLSKGEFPITTLRPIPIKSAIKEIFWIYQDQTNDLVVLNDKYGVTYWNDWEVGHTGTIGQRYGAVVKKHNIISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSECNPKLVLNVPDGTDFFDIKPDDFALVDYDPIKPQLRFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_PROMM
Sequence: MPSSRTCVGVVFGGASEEHAVSIRSAITVVGALRSEVNNNRFEVIAIYIDQRGRWWPAGVAEAVLKQGHPAKPEQLSTPLAPQGFTKLPEGSERVQVWYPVLHGPNGEDGTVQGLFTLMGQPFVGSGVLGSALSMDKLAMKAAFAAAGLPQVPYAAVDAADLLETESRQGVAKHLEAKLKYPCFVKPANLGSSVGISKAQNRNELLIGLDKAASLDRRIVVEQGVSARELECAVLGKRELQTSVVGEICFDADWYDYDTKYSENCSHTLIPAPLPEGVEAQIRTLALQACRCVAAHGMARVDFFYNAARNEIWLNEINTLPGFTSQSMYPMLWEASGVTLEELVSQLVITARE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_BACFR
Sequence: MRKAKPKKRVILPDPVFNDQKVSKFVNHLMYDGKKNTSYEIFYAALETVKAKLPNEEKTALEIWKKALDNVTPQVEVKSRRVGGATFQVPTEIRPDRKESISMKNLILFARKRGGKSMADKLAAEIMDAFNEQGGAFKRKEDMHRMAEANRAFAHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL29_WIGBR
Sequence: MNLKNLRKKNKKELNNELLNLLREQFNLRMQAGNGQLQHTHLLKEVRKNLAYVKMLINEEKKGRNNNG
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: UPP_PSEA8
Sequence: MPVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTKQKEA
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PSAB_PROM1
Sequence: MATKFPSFSQGLAQDPTTRRIWYGIATAHDFESHDGMTEEQLYQKLFSTHFGHLAIIGLWVAGNLFHIAWQGNFEQWVLDPLHTRPIAHAIWDPHFGQGLTDALTQAGATSPVNIAYSGLYHWWYTIGMRTNEQLFQGAIFINILVCWLLFAGWLHLQPKYRPSLAWFKNAESQLNHHLAVLFGFSSIAWTGHLIHVAIPESRGIHVGWENWLTVMPHPEGLTPFFSGNWGAYAQNPDSIDAVFGTSQGAGTAIFTFLGGLHPQSESLWLTDIAHHHLAIGVVFIIAGHMYRTNFGIGHSLKEIIEAHNTSHPKDPHRGYFGIKHNGLFETVNNSLHFQLGLALASLGVACSLVAQHMGALPSYAFIARDYTTQSALYTHHQYIAMFLMVGAFSHGAIFFVRDYDPELNKDNVLARILSTKEALISHLSWVTMLLGFHTLGIYVHNDVVVAFGTPEKQILIEPVFAQFAQAASGKMMYGFNALLANASSSASIAANSMPGNHYWMDMINRPDALTNFLPIGPADFLVHHAIALGLHTTALILIKGALDARGTKLIPDKKDLGFAFPCDGPGRGGTCDSSSWDATYLAMFWALNTIAWITFYWHWKHLAIWMGNTAQFNESGTYLMGWFRDYLWLNSSQLINGYNPFGVNALSPWAWMFLFGHLIWATGFMFLISWRGYWQELIETLVWAHQRTPIANLVGWRDKPVALSIVQARLVGLTHFTVGNFVTFGAFVIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: DER_SHIB3
Sequence: MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEIEGREFICIDTGGIDGTEDGVETRMAEQSLLAIEEADVVLFMVDARAGLMPADEAIAKHLRSREKPTFLVANKIDGLDPDQAVVDFYSLGLGEIYPIAASHGRGVLSLLEHVLLPWMEDLAPQEEVDEDAEYWAQFEAEENGEEEEEDDFDPQSLPIKLAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGREYVLIDTAGVRKRGKITDAVEKFSVIKTLQAIEDANVVMLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVKEQVKETLDFRLGFIDFARVHFISALHGSGVGNLFESVREAYDSSTRRVGTSMLTRIMTMAVEDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRKSLDVMGSPIRIQFKEGENPYANKRNTLTPTQMRKRKRLMKHIKKNK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PA2G4_HUMAN
Sequence: MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENEAGD
What is the function of this protein?
May play a role in a ERBB3-regulated signal transduction pathway.  Seems be involved in growth regulation.  Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG).  Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity.  Binds RNA.  Associates with 28S, 18S and 5. 8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA.  May be involved in regulation of intermediate and late steps of rRNA processing.  May be involved in ribosome assembly.  Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).  Regulates cell proliferation, differentiation, and survival.  Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
What are the official names of this protein?
Proliferation-associated protein 2G4, Cell cycle protein p38-2G4 homolog, hG4-1, ErbB3-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24 family.
Protein: MYCN_HUMAN
Sequence: MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
What is the function of this protein?
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
What are the official names of this protein?
N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37.
What are the subcellular locations of this protein?
Nucleus.
Protein: EB1_DICDI
Sequence: MEGFGRNEILNWINDLLQLDYKKIEQLGSGAALCQLVDIIHPGKINLKMVNFNAKYDYEYIKNFSYLQESFAKLGVEKYVEVSELVKSRPQANLEFAQWMKKYFDQYYTGEPYNAIERRIALKIPTDKDRSSLKGKTAATGAPPTSKPSPSSTLKPATTAASKPAPVSKPTTTTAKPTPSSVSKPVSKPTPSSISKPVSKPTPSISKPVTKPTPTTTSTSTTTTVSTPPSTPKPTNTPIPSTTGKPTLTQPTFKPTPKSVSPTPPVVAGSTVTTKTVIVSEPPTELLEELEQQKRELEQQRKELEEQKSVIQEMTEKIANFEITIQDIEKDRDFYFERLREAEIFCQDHSDVPLLGEVLKILYNSNGEEEGEEGEGEEQGGEEEEEEEEQGENNIEQEEEEQIEQQQQQQEEEEEHERETLSEPEPDQDNSAIPLEQLEINDEEEEFNQHQEQEEEDEHFEDEEKVNGLNEEEIMNSVLQNASDEDDILESTFDGNEDDSLLQDEY
What is the function of this protein?
Involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.
What are the official names of this protein?
Microtubule-associated protein RP/EB family member 1, DdEB1.
What is the protein family that this protein belongs to?
Belongs to the MAPRE family.
What are the subcellular locations of this protein?
Cell projection. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Chromosome, centromere, kinetochore. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Protein: PSBZ_CHAVU
Sequence: MIIAFQFALFALVAISFILVVGVPVILASPEGWSNTKNAVFSGASLWIFLVFVVGILNSFIA
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: YIDC2_LISIN
Sequence: MKKKKRFKQKLLIASLVIGLVAVLSGCGYSTDPITKDSTGFWSHYIVFPLSWVITWFSDLFGGNYAVGIIVVTILIRLLIMPLMIKQLKSQKAMTSLQPKIKELQEKYSSKDNETKQKLQQETMRLYQENSVNPMMGCLPLLIQMPILLGFYQAISRTAEIKTDTFLWMQLGNPDPYYILPIVAALTTFLSSKISMMGQTQQNKSMAMIVYIMPVMILFMGITLPSALALYWIIGNIFTVFQTLLINNPFKNKREQEALAAAQLEEERLKKKAANMKASKKGGKKRK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC 2, Foldase YidC 2, Membrane integrase YidC 2, Membrane protein YidC 2.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUDT8_HUMAN
Sequence: MLPDCLSAEGELRCRRLLAGATARLRARPASAAVLVPLCSVRGVPALLYTLRSSRLTGRHKGDVSFPGGKCDPADQDVVHTALRETREELGLAVPEEHVWGLLRPVYDPQKATVVPVLAGVGPLDPQSLRPNSEEVDEVFALPLAHLLQTQNQGYTHFCRGGHFRYTLPVFLHGPHRVWGLTAVITEFALQLLAPGTYQPRLAGLTCSGAEGLARPKQPLASPCQASSTPGLNKGL
What is the function of this protein?
Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity).  Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
What are the official names of this protein?
Mitochondrial coenzyme A diphosphatase NUDT8, Nucleoside diphosphate-linked moiety X motif 8, Nudix motif 8.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DMAW2_CLAP2
Sequence: MSTAKDPGNGVYEILSLIFDFPSNEQRLWWHSTAPMFAAMLDNAGYSVHDQYRHLSIFKTHIIPFLGVYPTKGQERWLSILTRCGLPLELSLNCTDSVVRYAYEPINEMTGTEKDPSNTLPIIGSVQKLAQIQAGIDLEWFSYFKDELTLDESESAILQDTELVKEQIKTQNKLALDLKESQFALKVYFYPHLKSIATGNSTHFLIFDSVFKLSQKHDSIQPAFQALCDYVSRRNDSSEVDQHRALHARLLSCDLIDPAKSRVKIYLQEQTVSLPAMEDLWTLGGRRVDASTMDGLDMLRELWSLLKVPTGHLEYPKGYMELGEIPNEQLPSLVNYTLHRNDPMPEPQVYFTVFGMNDAEISNALTIFLQRHGFADMAKKYRVFLQDSYPYHDFESLNYLHSLVSFSYRRNKPYLSVYLHTFETGRWPVVADSPISFDAYRRCDLSTK
What is the function of this protein?
Catalyzes the first step of ergot alkaloid biosynthesis.  Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants (By similarity).
What are the official names of this protein?
Tryptophan dimethylallyltransferase 2, 4-dimethylallyltryptophan synthase 2, All-trans-hexaprenyl-diphosphate synthase 2, L-tryptophan dimethylallyl transferase 2, DMATS 2.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: TSG13_BOVIN
Sequence: MGQRRQTKSQHAKPRTFRTSPVMFEKEIFFDSDEIIDAVGQSKFVLKNLHHYTVHPNLAQYYEPLKPTALQKFLARNRKIQSFTLKVIEYDQDKTLLILTNNPLPCPIDHQGKDVTPKYFSNELLLKESHQHKPTENFFLPLMPQKKNLRSGLKPVFPLMLLEDTKSKREQWFRFSTDNDFKSEGKYSKVYTLRQQKKMYPQLTFASVCKKYMKNDVSKKSGSDSPTSQMIWEPLTLSSLLEKKPTRTAPGESEFRNGRAQQWFIKSATVIK
What are the official names of this protein?
Testis-specific gene 13 protein.