PharMolix/UniProtQA huggingface dataset:
Protein: KBAZ_ENT38
Sequence: MKHLIEMVESHKQGAENGIYAVCSAHPLVLEAAIRFARTHNAALLIEATSNQVDQFGGYTGMTPADFCGFVHQLADSLNFPRSMLILGGDHLGPNRWQHLTADDAMENAQTLIKSYVAAGFKKIHLDCSMSCEDDPIPLTDEIVATRAARLAKIAEETSDACFGESDLVYIIGTEVPVPGGAHETLSELVVTTPDAARATLEAHRHAFEQQGLSAIWPRIIGLVVQPGVEFDHTNVIDYQPEKAAALRAMVEGYDTLVFEAHSTDYQTPQALRQLVKDHFAILKVGPALTFALREALFSLAAVEEELLPMKAGSGLRHVLENVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFERLVRNLADDPIPLPLVSQYLPLQYSKVREGALKATPRELIIDHIQDILRQYHDACQRVTPHNA
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: RL19_VESOH
Sequence: MNLIDQIENEQLRSDLPLFVSGDTIIVQVKVREGERERLQAFEGVVIAKKNRGIGSAFTVRKISHGEGVERVFQTHSKMIDSIKVKRRGKVHQAKLYYLRGLTGKKARIKEKLQIRK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: Y1134_SHELP
Sequence: MGVVTKEQDDLVIRLYIQPKASRDQIVGPHGDELKVAITAPPIDGKANAHLCKFLAKQFKTAKGNILIEKGELGRHKQIRVVMPKEIPEAISVLIP
What are the official names of this protein?
UPF0235 protein Shew_1134.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: CHA3_LYMDI
Sequence: MNTFALLSVFIQACLVQSVFSQCTSRAAVAADRGIIGGYGFGAPCGLAGGYGLEAPYGWAGYADYGYPAGAYGIDAYGGIGEGNVAVAGELPVAGTTAVAGQVPIMGAVKFGGDVCAAGSVSIAGKCACGCGDYGYGYGLGAPYLY
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class A protein Ld3/Ld29.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: GSP1_YEAST
Sequence: MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDEDDADL
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.  Essential for cell viability.  By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1.
What are the official names of this protein?
GTP-binding nuclear protein GSP1/CNR1, Chromosome stability protein 17, GTPase Ran homolog, Genetic suppressor of PRP20-1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SSRP_CORJK
Sequence: MAAKKSTPTDSGKSKGKKNKAQKGAGQKGAGQIVVATNRKARHDYHIIDTYECGVVLVGTEVKSLREGKASLVDAYATIDEGEVWLRGLHIPEYSMGHWTNHSPRRTRKLLLHRREIDSLMGKVRDGNNTLVPLQLYFVAGKLKVELALARGKQEYDKRQDIKRRTEEREITREMGRRIKGIQG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RS21_ORYSJ
Sequence: MQNEEGQMVDLYVPRKCSATNRIITAKDHASVQINIGHVDENGLYDGRFTTFALSGFIRAQGDADSALDRLWQKRKAEVKQQ
What are the official names of this protein?
40S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS21 family.
Protein: UPP_ACIET
Sequence: MSNVHVIDHPLVQHKLTLMRKKDASTNSFRRLLGELSTLMAYEVTRDMPLQDIQIETPLETMTGKVIDGKKLVLVSILRAGNGFLDGMLNVVPGARIGHIGLYRDPDTLQPVEYYFKMPSEMAERDIIVVDPMLATGNSAAAAVARLKQLQPRSIKFVCLLAAPEGVATLQKAHPDVPIYTAAIDRELNDHGYILPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ORF57_VZVD
Sequence: MDVRERNVFGNASVATPGEHQKFVRELILSGHNNVVLQTYTGKWSDCRKHGKSVMYNTGEARHPTCKAHQR
What are the official names of this protein?
Uncharacterized protein 57, Uncharacterized ORF57 protein.
What is the protein family that this protein belongs to?
Belongs to the varicellovirus ORF57 protein family.
Protein: ASSY_CLOAB
Sequence: MKEKVVLAYSGGLDTSVTIPWLKDNYDVEVIAVCVNVGQEDDMDKVKEKAVNSGAAKIYVEDVKEEFVTEYLYNAIKWNATYEGKYLLGTSFARPLIAKKLVEVAHKEGAKYICHGCTGKGNDQVRFETAIAAMDPYIKIIAPWRLWNIDSREAEIDYALSKGVEVPVTKEKIYSEDWNLWHISHEGGDLEDPKNEHKEEMYKCVTPPEEAKDEPAYISIYFEKGVPCKINGEELEPVKLIEKVNKVAGENGIGVVDLVENRLVGMKSRGVYETPGGTLLYEAHAQLERLTVDKDAYHYKQVLALKYSELVYDGLWFTTTREALDAFVDTVEENVTGTVKLKLYKGNMKVSSVESENALYDEGISSFGASDLYDHKDAQGFINLFSLPSKIKAMKKLEKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG22_COCIM
Sequence: MTSSPPSTWRNLDENEALLRHPILNKYPGEDTRPTSKKELAGWYSYGWAAEVFAVCAMGSFLPITLEQMTRDQGVLLSDKKTPCSASWPTAPTAYAAADATASPRVGPPQCVIYVLGIEINTASFAMYTFSISVLIQSVLIISMSAAADHGVYRKKFLLAFALMGALSMILFLFLLPRFYLLAAVLAIIANTGFGASFVLLNSFLPVLVRNDPSIQATRYAAASDEQTYYTQNPSGSNTISPVDEPERLDVSSNDSALVSAELRLSTKLSSNGIGIGYIAAVLVQIGCILLVVATHSTTFSLRLVLFIIGLWWLVFTIPAALWLRPRPGPPVPDSAYGKGRWAWVSYIVFAWVSLGRTIVRARQLKDVLLFLAAWFLLSDGIATVSGTAVLFAKTQLGMNIAALGLINVIAMISGVLGAFSWSYISHHFNLRPSRTIVACICLFEVIPLYGLLGFLPFIKRLGVIGLQQPWEMYVLGAIYGLVLGGLSSYCRSFFGELIPPGFEASFYALYAITDKGSSMFGPAIVGAITDRYGEIRPAFGFLALLILLPLPLMLLVDVDRGKRDAKELAEALEGVKDMGTNGTGYATVATHEVEVGYEGDRE
What is the function of this protein?
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation.  The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
What are the official names of this protein?
Autophagy-related protein 22.
What is the protein family that this protein belongs to?
Belongs to the ATG22 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Protein: W4937_FUSPC
Sequence: MPRPADTYTHDQGHLQNCPEYVAWRVAGNGQELAPTNPYNATGRRAFADSYGFDNSNLDLRPDQEVPTMQRIRSTLDMSKYFDEFFDDSLDHKCARVRCRSCGFVRAKNATRQADHLTQCKDFLATDEGEELMASGSLVHNVQQHQPPAIWNGARPHPDLMVRHLSNHPPSGTVPVGPCSRPEPSRASQRPEPPSLAQHLLDQSDDLLTNAVQHSFLAHAGSGSLSENDFNQWLAQIGYISRSLVPFTGALIGKIRIPETGNLEHDSTFRCLDLLCSAVTNMKKELEFLEATKREYGLEVGLDEPRPATKSFIDLFNSASCASATLLEGMVLLWAVEILFYNSFSYAGSFVAQPMPTQERSSFSLPSYSLPSSASPGAYSGQTIRKDRHTTALREAFIKNWKSENFSQFVDVCKSIVDELAMDQMTGNGRADTSACERVFNQAVWLWAQVFPQTTGIRTGHEDSSRDGGRENKAMNRNRSTGNSVEIEDEYNVQTSTQLE
What is the function of this protein?
The two putative transcription factors FPSE_09188 and FPSE_09189 could be responsible for orchestrating expression of the W493 A and B biosynthesis cluster genes (Probable).  W493 A and B consist of six amino acid residues D-allo-thr, L-Ala, D-Ala, L-Gln, D-Tyr, and L-Val/L-Ile linked to a 3-hydroxy-4-methyltetradecanoic acid polyketide chain (PubMed:25412204).
What are the official names of this protein?
Probable transcription factor FPSE_09189, W493 A and B biosynthesis cluster protein FPSE_09189.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL4_TROW8
Sequence: MSPSATVFDIGGNAVGTLQLVGHLFDSDPNLHLIHQVVVAQQAAFRQGTHKTKSRAEVSGSGRKPFRQKGTGNARCGSTRAPQMRGGGVVHGPVPRSYVHRTPKKMIKAALAGCLTNRARAGRVHIVDSFGDTPSVADALTLFQITGLSSKLLVVAQASDSVAYRSVRNIPGVRLVHVGQLNSYDVLRSDDVLFTRGAYNVFVGPSGDLAFSEDRDNPGTSLPKSPTPEDSSDATKARSSRHDDRTGA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MURI_STAHA
Sequence: MNKPIGVIDSGVGGLTVAKEIMRQLPNETIYYLGDIARCPYGPRPGDEVKQFTTQLANKLMQFDIKMLVIACNTATAVALEHLQQMLPIPVIGVIEPGSRTAIMTTKNQNVLILGTEGTIKSEAYRHHIKHINPNVHVLWCGLPGFVPLVEQMRYDDPTITSIVIHQTLKQWRNTDADTIILGCTHYPLLYKPINDYFGGEKKVISSGLETAREVSALLTFSNEHASYTQHPEHRFFATGDTVHIKNIILQWLKLDVEVERISVDE
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CHDC_GEOKA
Sequence: MSEAAQTLDGWYCLHDFRTIDWSAWKTLPNEEREAAISEFLALVDQWETTESEKQGSHAVYTIVGQKADILFMILRPTLDELHEIETALNKTKLADYLLPAYSYVSVVELSNYLASGSEDPYQIPEVRRRLYPILPKTNYICFYPMDKRRQGNDNWYMLSMEQRRELMRAHGMTGRKYAGKVTQIITGSVGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARFGEFGSFFVGTRLSVEKVPSFFHV
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: SURE_CLOB6
Sequence: MNILLTNDDGIEAEGINTLAELLSKYHNVTMVAPENQRSASSHSITIYEPIIVKQVKKPYNVEAYSISGTPADCVRVALDKLVPDNIDMVISGINKGLNIGNDILYSGTVSAAIEGSMYKVPSMAVSAQFIKNKKENYKIAAKYALDMLNRLKKEDLKNDVVLNLNIPFCSEEEIKGIKVCKVGNKIFNTRFSEEIDEEGNKILKLEGDINEDIYDGTDVYYIRNKYVTLTPLHYDLTNFNILEETEQLFLS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ART1_SCHPO
Sequence: MTSPCTLIRQFSPLEIRPLPHLDFQAGFNGIPTSAPRLVGIVQVRSKEIHQPLALVQITLELWKIESVVIPSLGISNHLSDNKCLARQVLFPLHSEHPENNIPPNDNNYSISDLSIKSPPPSLTSDWIVDSYASDQDNPSVHTHNRTTPPIPPPHLPNASGSSVYQPPYTPFRSVSTTSSSNDTSITPFGDQTPILSSSSDPYATHRVWSMDLPFEIPFPENSEIPSTFELNRSGTICSTKYELRAHMSLLGVPDITTTVPVSLSRYDNLSSWGMYNSPTNIRQVSSDGRVVVEVSIPKLCIGPSDLVSVFVSIMPNNGSKIRVQQLSLSLVEYITFIHPSSSSPIVRKKKVLRYEEDLDDMKLTSEGLSKSLSKPFPDIDFEDANITGFTTTSDLYSVQYMLVIKVQLYRARNIEITNPIIVSPVERSRSQALLNEIQTRVLDVRQSHGGVVLEENVRIVRASDFSKNNMFAYLNDDIVLLS
What is the function of this protein?
Involved in cytokinesis.
What are the official names of this protein?
Arrestin family protein 1.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: MSCL_SYNE7
Sequence: MTSRRGRAVGFIRDFQAFILKGNVVELAVAVIIGGAFNKIVSSFVGDLVMPLVNPLIPGGDWRTAVIGPGLKIGSFAGSVIDFLIIAFVLYLAIRAIERFKRKEEAVVAAAEPDVQQQMLATLERIADNLEAR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCF4_CITSI
Sequence: MSWRSEYIWVEFIAGSRKPGNFFWAFILFLGSLGFLVVGISSYLDRNLLSLFPSQQINFFPQGIVMSFYGIAGLFISSYLWCTIIWNVGSGYDRFDTKEGIVCIFRWGFPGKNRRIFLRFLMKDIQSIRIEVKEGIYARRVLYIESRGLGAIPLNRTDENLTPREIEQKAAELAYFLRVPIEGF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PMP22_PONAB
Sequence: MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKRE
What is the function of this protein?
Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
What are the official names of this protein?
Peripheral myelin protein 22, PMP-22.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_BACAN
Sequence: MAVPFRRTSKTVKRKRRTHFKLSVPGMVECPSCGEAKLAHRVCKACGTYKGKEVISK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: TX5A_DINQU
Sequence: MNIRLMFTLIALLVLTVSFSGANSCFKRNRQCKGSFLKSACCEGLKCVNGRCT
What is the function of this protein?
May have neurotoxic activity.
What are the official names of this protein?
U1-poneritoxin-Dq5a, U1-PONTX-Dq5a, Dinoponera ICK-like toxin, Poneratoxin.
What are the subcellular locations of this protein?
Secreted.
Protein: DEF_SHIDS
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: GP63_CRIFA
Sequence: MHAPPTATRRSGPRRTHGIMARLVRLAAGVLVVTLVIGALTALSADDAKTHPHKVCIHDELQQSLLDSVAQQGLAPQRVSRVGLPYVASATAAPAAQVGGVDFALAGDSAPDVTRSAEWGELRITVSAEELTDPAYHCATVGQVISNHIDDYVTCTADDIMTAEKLDILMNYLIPEALQMHKDRLQVQQVQGTWKVARMTSYCGRFKVPEEHFTTGLSNTDFVLYVASVPTSPGVLAWANTCQVFSNDQPAVGVINIPAATITERYDHLMVHAVTHEIAHSLGFSNAFFTNTGIGQFVTGVRGNPDTVPVINSPTVVAKAREHYGCDDVTYVELEDAGGSGTMGSHWKIRNAQDELMAGISGVAYYTSLTLSAFEDLGYYKANYSNAETMKWGKDVGCAFLTGKCVVDNVTQFPSMYCDKDENVYRCHTARLNLGSCEVTDYTFDLPDYLQYFTVPSVGGSADYYDYCPYIVRSPIGSCTQAASSASPFVSAFNTFSMASRCIDGTFTPKSTGGATVTAHLGMCTNVACNTADKTYSIQVYGNGAYIPCTPGATISLDTVSDAFEAGGNITCPPYLEVCQSNVKGAMDYESMTNSGSGSSRPAPVEPSGSGSGSSAATTAPSPTRDGSAAADRIAPRTAAVALLALAVAAACV
What is the function of this protein?
Plays an integral role during the infection of macrophages in the mammalian host.
What are the official names of this protein?
Leishmanolysin homolog, Cell surface protease, Major surface glycoprotein, Protein gp63.
What is the protein family that this protein belongs to?
Belongs to the peptidase M8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CBP4A_DICDI
Sequence: MVTKKEFLEDLTNATNEMIKAGDKNGDNQLSKKELYELFKKCKYPNPTLVTNSLLELFDLDKDGKLSVNEVKTALLVDYIIEAETCLKKFVDSIFKADSNKDNKITWDEARQFFVTSGSNEAQAKVFANSMFEDVDSDDDKCITREELREYAIEYYEIYPTE
What are the official names of this protein?
Calcium-binding protein 4a.
Protein: PSAF_GLOVI
Sequence: MSNKQSRVPFGAALLGILTLLLLFETGAFAQTQVKDPLKLCKDVPAYQELKTQRLEAAQKAQADGKPVTFNEAGTKQKFERYDTAYCGQDGYPHLITSGQLDRAGDFLIPSVLFLWIAGALGWAGRLYLAESKGPEDEIIIDLPKAIKCLLLGLIWPVQAIPELISGKIRVPEDRVTISPR
What is the function of this protein?
Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria).  This plastocyanin-docking protein contributes to the specific association of plastocyanin with PSI.
What are the official names of this protein?
Photosystem I reaction center subunit III, PSI-F.
What is the protein family that this protein belongs to?
Belongs to the PsaF family.
What are the subcellular locations of this protein?
Cell inner membrane. Note=The soluble domain is associated with the lumenal side of the cytoplasmic membrane.
Protein: HOA_MYCTO
Sequence: MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
What is the function of this protein?
Involved in cholesterol degradation.  Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and propanal.  Can also catalyze the cleavage of 4-hydroxy-2-oxopentanoate (HOPA) to pyruvate and acetaldehyde.  The aldehydes produced by this reaction are directly channeled to the dehydrogenase HsaG.
What are the official names of this protein?
4-hydroxy-2-oxohexanoate aldolase, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase, 4-hydroxy-2-oxovalerate aldolase, HOA.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: SYP_STRSV
Sequence: MKQSKMLIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLPLANRVIEKAKRIMREEFDKIGAVEMLAPALLSADLWRESGRYETYGEDLYKLKNREKSDFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDAYSFHANYDSLDVAYDEYKSAYEKIFTRSELDFKAIIGDGGAMGGKDSQEFMAITPDRTDLNRWVVLDKSVASFDEIPEDVQEAIRTELTSWMVSGEDTIAYSSESSYAANLEMATDEYKPAGRVVTEEEVARVSTPDCKTIDEVAAFLGLDESQTIKTLVYMADESPVVALLVGNDQLNEVKLKNHLAADFFDVASEDQVRQLLGAGFGSLGPVNLPEGVRIIADRKVQDLANAVVGANEDGYHLTGVNPGRDFTAEFVDIREVREGEISPDGQGVLKFARGIEIGHIFKLGTRYSDSMNANVLDENGRAVPMIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEFRYAWGINFPKELAPFDVHLIPVNVKDEEALALTDQIEANLLSAGYEVLVDDRNERAGVKFSDSDLIGLPIRVTVGKKAAEGIVEVKIKATGDTIEVHADNLLETLSILTK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN684_HUMAN
Sequence: MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKVEQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYNMSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKNHTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQCIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRCGKAFSQKSNLIVHQKIHT
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 684.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTHP_NEIMB
Sequence: MLKQSIEIINKLGLHARASNKFTQTASQFKSEVWVTKNDSRVNGKSIMGLMMLAAAKGTVIELETDGADEAEAMRALTDLINGYFGEGE
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain.
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK1_CYACA
Sequence: MVKIRSRRFKILQSQISVEKMCEPIEAINLLKSGPKAKFSETFEVHCCLDLNTKYSDQQLRASVVLPKGTGKRTKIAVITNEAEVNKIKNFGVDIVGSKDLVESIANGFLEFDQLLTTPDMMPVIAKVGKILGPRGLMPSPKSGSVTSDIYNAIQEFKKGKLEYRTDKSGIVHSIIGKIDFTAEDLLNNLIAIKKSIDQNRPNGAKGKYWKNMYLCTTMSPAIKIDFNKLQELEKNYGQN
What is the function of this protein?
Binds directly to 23S rRNA.  Might be involved in E site tRNA release (Potential).
What are the official names of this protein?
50S ribosomal protein L1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y582_MYCPN
Sequence: MWVALKRFGFLSGLLALTVLSACSAFRKPDKFEGYYINNIPGSAEIDHANYDLTFFLGFFNRIEKTEKDKSQIDFGSIHGTGWLIDWKEVDKKDKKANKFTVYLATNLHVIQALKNREDHPPYNQFDINFVRTVDFRIGKYTDVKQFVAPSKLGLPNSTQAFVAAQPTVLPKTAFIAHDFVNYTLSKDQKNKKQREQQWKVQIKPNKDEVHPYADSAVLELPLFLNNSSDRQIFDHFIQPAIRAYKQLGDSLNIFAYPTLDQFKHSHYYVLGYPYIAKKLPTLFVNQTGKEKTVPGETAQIPNDQPFVSTINEEGPHLGRIKSDKFNGGTWAWNHDNTKNFPFNRQFRGKEYQMYGKGIGITNGSLSRGASGSLVLNNKRQIVAIYFASRITETQEWGLAQLLRWKPRSVLNEEKDSVAYDLIFGNSNTKKYYAQFAKK
What are the official names of this protein?
Uncharacterized lipoprotein MPN_582.
What is the protein family that this protein belongs to?
Belongs to the MG067/MG068/MG395 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ISPH_ESCF3
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.