PharMolix/UniProtQA huggingface dataset:
Protein: PAG70_BUBBU
Sequence: RGSXLTILPLRNIID
What are the official names of this protein?
Pregnancy-associated glycoprotein 70, PAG 70.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBA1_LIPTU
Sequence: MSLSTKDKETVKDLWGHISASADAIGADALGRLLVVYPQTKIYFLHWPDLSPNSPSVKNHGKNIMSGIALAVTKIDDLKSGLNALSEQHAFQLRVDPANFKLLSHCILVVLAIRFPHEFTPEAHVAMDKFFCGVSLALAEKYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PIPNB_MOUSE
Sequence: MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA
What is the function of this protein?
Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (By similarity).  Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).
What are the official names of this protein?
Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta.
What is the protein family that this protein belongs to?
Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein: DAPH_BACHK
Sequence: MKMMDANEIISFIQKSEKKTPVKVYIKGDLKEVTFPETVQAFVNKKSGVLFGEWSEIKTILDENSKYIVDYVVENDRRNSAIPMLDLKGIKARIEPGAIIRDHVEIGDNAVIMMNATINIGAVIGEGSMIDMNAVLGGRATVGKNCHVGAGAVLAGVIEPPSAKPVIVEDDVVIGANVVVLEGVTVGKGAVVAAGAVVTEDVPPYTVVAGTPARVIKEIDEKTKAKTEIKQELRQLNPEK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: DUT_BARBK
Sequence: MSLQDAHNSSSPSQKLPLWVQCLEHGQGLGLPHYATEGSAGLDLRAALPENESITLSPGQRALIPTGLIFHLSPGFEAQIRPRSGLALKNGITCLNTPGTIDSDYRGEVKVLLINLGQEDFIIERGMRIAQTVIAPVTQVEVRLLDPNSDLTSSQTDLSNQPNTGRGTGGFGSTGQK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: LCL3_CANDC
Sequence: MPPIPPDPTESISIFHPKVILLSAGVTTSLFFGYKFYKRYIRRIKTYLDLTPTIIENNTKLYGYVTRVGDGDNFRFYHTPGGWIFGWGWLRKIPTTRKDLKDETLMIRLCGVDAPEGAHFGKPAQPFSKEALHWLREYVDGKYVTITPYSIDQYKRVVARAQIWKWTGKKDISAEMLKVGYAIVYEGKAEAEFGDNEDWYRKLESRAKLLRKGVWSLGKNLTTPGEFKRIHYRGE
What are the official names of this protein?
Probable endonuclease LCL3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: ACHA_NAJNA
Sequence: NPPAIFKSYCEIIVTYFPFDEQNCSMKLGTWTYDGTVVAIYPEGPRPDLSNYMQSGEWTLKDYRGFWHSVNYSCCLDTPYLDITYHFILLRLPLYFIVNVIIPC
What is the function of this protein?
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: DCTA_CUPPJ
Sequence: MRKPFYKILYVQVLFAIFVGILLGHFWPDTGVAMKPLGDGFIKLIKMIIGPIIFCTVVTGIAGMSDMKKVGRVGGKALLYFEIVSTFALLIGLGAAHLLKPGVGFNIDPATLDTKAIEQYVSKAHGQSTVEFLMHIIPDTIFSAFSNGDILQILLVSLFFGAALAAIGERARIVVQLIEQVSKVFFHIVHVITKVAPIGAFGAMAFTIGKYGLGSLVPLLKLIGTFYFTAIVFVVFVLGAIARATGFNILRFISYIKEELLIVLGTSSSEAALPHLMEKLEKLGCSKSVVGLVVPTGYSFNLDGTNIYMTMAVIFIAQATGIELTLLQQLTILGVAMLTSKGASGVTGAGFITLAATLAVVPTIPVAGMVLILGIDRFMSECRALTNIIGNGVATVVVSAWEHELDRAQLKRTLQQGGEDEAELADAGQNV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HESXA_XENLA
Sequence: MSTGLQKGSRLMENRSPPSSFSIEHILGLDKKMDVASSPIIKHHRPWIECSSKVDGTFRQIPLIYDLPVQVDAMRRSAEEETKIRLDRGEEERLTYKREQSWYRGRRPRTAFTRGQIEILENVFRVNSYPGIDVREELASKLALDEDRIQIWFQNRRAKLKRSHRESQFLIVKDSLSSKIEE
What is the function of this protein?
Appears to be involved in the regional specification of the anterior head of Xenopus embryos.
What are the official names of this protein?
Homeobox expressed in ES cells 1-A, Homeobox protein ANF-2, xANF-2.
What is the protein family that this protein belongs to?
Belongs to the ANF homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCP2_CAEBR
Sequence: MPYVGVGAQKASTNLTGGPMMKAYAFVLAFFLLGLGVLALGKHHSGRRFNQYSKVSIDDIHETDAKTIQDNIKSENIKKYLRIFTQEPHIAGTDANKKVAYAIASAWTEAGLEDVHTLPYEVLLSYPDFENPNSVVIQNSAGKEIFRSKGVSPVIIPDEQSGKYAGHQWLAYGGNGTVSADVVYINRGNANDFKNLKLMGVDVKGKIALMRYGHGFRGDKVYKAQQAGAIGAILFSDTSDVAQDGVDSEHVYPKTIWMPNEGVQRGSLMHGDGDPLSPFYPSKKELFKGRTIEEAKDDGTLPSIPVLPVSYTTALQLLKRMSGRAVPSDWQGFVGGNLTYKLGPGFVNGEKLTINVHSELKTKRIRNVIGYIRGAEEPDRYIMLGNHFDAWVYGSIDPNSGTAVLAEVARAMMQTINETSWRPARTIVFNAWDAEEFGLIGSTEFVEEFVDVLQKRAVVYINMDCIQGNASLHVDTVPTLEHIAIEAAKHVPNPSKRERSRGRNTVYDTWMKVFPEKKAGRPKIRVPGGGSDHAPFLNFAGVPVINFNYKNYTTFDTYPLYHSMYETPFTNIHLMDTEDLAVHRAIGQYWAELAKTFADEVVLPMNTTNLASVMIKSYLPQLKASISGINVSRIDFESIRTQYALLSKSSQDLLVMSKKFQETMQFTFHSFSQNPYDAKHVNAVNERLISTERCFINPRGVSKHNPSARHVLFSVSDSDSYSNSLMAGIQNAIHSYETSPSKKNLREIINQISTVQYSVICVVNTLRDVI
What are the official names of this protein?
Glutamate carboxypeptidase 2 homolog, Glutamate carboxypeptidase II homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SYN_RHOBA
Sequence: MWWRRSRTNSLRYTVHPFASLQRSMIAPMDWTTIDACRTSTELPRPVEIRGWIRTRRDSKGGFSFLEVNDGTSLGNLQVVAPAELENYAEEIQKLTAGCSVVVQGELVESPAKGQSTELHASSVRVIGWCDGETYPLQKKRHSFEKLREWSHLRARTNTLGAVMRVRNRISQSIHRFFDDEGFNYLHTPIITASDCEGAGEMFRVTTLNLEKLAGSNRPFDTKQDFFQKPTHLTVSGQLEAETYATALSRVYTFGPTFRAENSNTSRHLAEFWMVEPEAAFYDLNDNMQLAERFLKRVFSDCLSHCGEDMDFFNERIEKGKIDQLKSVIEKPFEHMTYTDAVERLLACDEKFEYPVNWGTDLQAEHERYLTSVVGGPVILTDYPSSIKPFYMRVSDDGKTVAAMDVLVPGVGEIIGGSQREERLDVLQRRMAEGGLDESEYWWYVDLRRYGTVPHAGFGLGLERAVQYVTGMANIRDVIPFPRTPGNAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1055_METJA
Sequence: MKYKNILVTGSAGFIGFHLSKYLMDNYEDLKVIGIDNLNNYYNPVLKEKRNEILKNYENYTFIKLDFSDWDDLVENLKDKEIDLIVHLGAQAGVRYSLQNPWAYIKSNEMGTLNIFEFARRFDIEKVVYASSSSVYGGNRKIPFSEDDRVDKPISLYASTKRSNELMAHVYHHLYGIKMIGLRFFTVYGEYGRPDMAYFKFAKNILLGKEIEVYNYGNMERDFTYISDVVDGILRAIKKDFDYEIFNLGNSKPVKLMYFIELIEKYLNKKAKKKFLPMQDGDVLRTYADLSKSEKLLGYKPKVTIEEGLKRFCNWFLENKDWLLRL
What are the official names of this protein?
Uncharacterized protein MJ1055.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
Protein: RNPA_STAAN
Sequence: MEKAYRIKKNADFQRIYKKGHSVANRQFVVYTCNNKEIDHFRLGISVSKKLGNAVLRNKIKRAIRENFKVHKSHILAKDIIVIARQPAKDMTTLQIQNSLEHVLKIAKVFNKKIK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PMA1_SCHPO
Sequence: MADNAGEYHDAEKHAPEQQAPPPQQPAHAAAPAQDDEPDDDIDALIEELFSEDVQEEQEDNDDAPAAGEAKAVPEELLQTDMNTGLTMSEVEERRKKYGLNQMKEELENPFLKFIMFFVGPIQFVMEMAAALAAGLRDWVDFGVICALLMLNAVVGFVQEYQAGSIVDELKKSLALKAVVIREGQVHELEANEVVPGDILKLDEGTIICADGRVVTPDVHLQVDQSAITGESLAVDKHYGDPTFASSGVKRGEGLMVVTATGDSTFVGRAASLVNAAAGGTGHFTEVLNGIGTILLVLVLLTLFCIYTAAFYRSVRLARLLEYTLAITIIGVPVGLPAVVTTTMAVGAAYLAEKQAIVQKLSAIESLAGVEVLCSDKTGTLTKNKLSLGEPFTVSGVSGDDLVLTACLAASRKRKGLDAIDKAFLKALKNYPGPRSMLTKYKVIEFQPFDPVSKKVTAYVQAPDGTRITCVKGAPLWVLKTVEEDHPIPEDVLSAYKDKVGDLASRGYRSLGVARKIEGQHWEIMGIMPCSDPPRHDTARTISEAKRLGLRVKMLTGDAVDIAKETARQLGMGTNIYNAERLGLTGGGNMPGSEVYDFVEAADGFGEVFPQHKYAVVDILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWLIIRNQLLNLELVVFIAIFADVATLAIAYDNAPYSMKPVKWNLPRLWGLSTVIGIVLAIGTWITNTTMIAQGQNRGIVQNFGVQDEVLFLEISLTENWLIFVTRCNGPFWSSIPSWQLSGAVLAVDILATMFCIFGWFKGGHQTSIVAVLRIWMYSFGIFCIMAGTYYILSESAGFDRMMNGKPKESRNQRSIEDLVVALQRTSTRHEKGDA
What is the function of this protein?
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump.  The proton gradient it generates drives the active transport of nutrients by H(+)-symport.  The resulting external acidification and/or internal alkinization may mediate growth responses.
What are the official names of this protein?
Plasma membrane ATPase 1, Proton pump 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TATA_BRADU
Sequence: MGSLSIWHWILVIAVVLLLFGRGKISDLMGDVAQGIKAFKKGMQDDDKPADKPEPAKSIEHNAAPTAARSDVGSKAV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: UBXN8_HUMAN
Sequence: MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN
What is the function of this protein?
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane.  May play a role in reproduction.
What are the official names of this protein?
UBX domain-containing protein 8, Reproduction 8 protein, Rep-8 protein, UBX domain-containing protein 6.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RLMH_BURTA
Sequence: MKLHIVAVGHKMPGWIATGFDEYAKRMPPELRIELREVKPELRSGSRTADSVMAAERQRIEAALPKNARVVALDERGRDWTTMQLAQALPAWQQDGRDVAFVIGGADGLDPQLKSRAELLLRVSSLTLPHGMVRVLLAEQLYRAWSITQNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGAL_ALTMD
Sequence: MKTVAQIVAQNDWQNPVVFQRNRVGGHSPHHGYKTLEDALHNANAQKYLLNGEWDFCLFDAPEQVPESLLAATLSAEERAKWQSIVVPSNWQLKGYDKPIYCNVKYPFPVNPPIVPSENPTGCYRTTFSVTSAQLSQRNHIVFEGVNSAFHLWCNGEYVGYSQDSRLPAEFDISNLLVEGENRLAAMVIRWSDGSYLEDQDMWWLSGIFRDVSLITKPRQHIQDVFVTPTLDACYRDATVSVRTSIKAQLRCKVGIQLFDGDTTVTEQIVTGTNNKRVDEKGGWDDVVFQTLEVKEPKHWTAETPYLYRIVVSLIDDSGNVIDREAYNVGFRNVEMKNGQLLVNGKAVLIRGVNRHEHHQVKGHAINEDDMLEDIKLLKQNNFNAVRTAHYPNHPRWYELCDEYGLYVVDEANIETHGMFPMGRLSRDPLWAGAYMARFTQMVERDKNHPSIIIWSLGNECGHGPTHDAMYGWAKSFDPSRPVQYEGGGADTTATDIIAPMYARVDTDVEDDAVPKWAIKKWLSLPGENRPVILCEYAHAMGNSLGSFDEYWKAFKDYPRLQGGFIWDWVDQGLTKHTDSGDAFWAYGGDFGDTDNDRQFCINGLLFPDRTPHPHLFEAKYCQQHLSFSLTEETDKWQLSVKSDYLFRHTDNELLRWQVLENGKPIIEGECPIYVAPQQAQTVSIAPEINFKAGALYHLNIDVVLANDCAWAKAGHVIDTAQLALANKSGLIPFVSTANVANENAESGVTVKAENTTLLVSVKNNVFSFNSESGLLTSWLHEDSEMLSAPLEDNFFRAPLDNDIGVSEVDNPDPNAWESRWRRAGIGKWDRICTSVDVEQSTFDVRITSLFEYHYNDKLIAATKWVYTINHQAALTVEVEVLLDDSLPPMPRIGLQAAVPAPRSNEQERMRVTWQGLGPFENYPDRKAAARFGEHSLSIADLQTHYIFPTDNGLRSDCKQLNISGLRVNGQFCFSVSEYGQVQLDTAKHTSDLMPQDCVFVYIDHAHMGVGGDDSWSPSTHKAFLIEEKCYRYSVTFCAKV
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: DAPEL_LACP3
Sequence: MKEADLITLRRQLHQIPELALQEKETHALLLKTIQGLPQTYFTIRTLPDLPTALLVKVQGRDPQRTIGYRTDIDALPVTEKTGLPFASKHSGIAHACGHDIHMTVALGILSYFAEHQPKDNLIFFFQPAEESKNGGKLAYDMGAFTGDWHIDEFYGLHDRPDLPAGTISTRLGTLFAGTTEINVDLIGKSGHAALPQNANDMIVAAASFISQIQTVVARNVGPTDSAVITFGLMRAGTIRNVIAGRAHLEGTLRGFTQQQIDFLQQRIRDIGQGIAASFNCQVKVALNQGGYYPVENNDKLTKNFIQVMKDDPDVTFVDTKPVMTGEDFGYLLNKIPGTMFWLGVNDPDSQLHAADFSPDEAALVPGVTAVVHFLEHRMLEKV
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: EFTS_RHOOB
Sequence: MANYTAADVKRLRELTGSGMMACKNALAEAEGDFDKAVEQLRIKGAKDVGKRAERTTAEGLVVSKDGVLLELDCETDFVAKNEDFLKLAESIVTVAAAAKPADVDALKALELDGKTVDTVIQEQSAKIGEKLVLSKIASFDGPVAVYLHKRSADLPPAVGVLVEYTGEGDAAAEAARGAAMQVAALKAKYVTRDEVPEDIVANERHIAEETARAEGKPEQALPKIIEGRVNGYFKDVVLTEQSSVQDSKKSVKAILDEAGVTIKRFVRFEVGASS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMBRL_PONAB
Sequence: MEAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHIFLTRFKKPAEFTTVDDEDATVNKIALELCTFTLAIALGAVLLLPFSIISNEVLLSLPRNYYIQWLNGSLIHGLWNLVFLFSNLSLIFLMPFAYFFTESEGFAGSRRGVLGRVYETVVMLMLLTLLVLGMVWVASAILDNNKASRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLARMFSVTGKLLVKPRLLEDLEEQLYCSAFEEAAPTRRICNPTSCWLPLDMELLHRQVLALQTQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAIHILELLIDEAAMPRGMQDASLGQVSFSRLGSFGAVIQVALIFYLMVSSVVGFYSSPLFRSLRPRWHDTAMTQIIGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLCLVKTFTAAVRAELIRAFGLDRLPLPVSGFPPRASRKTQHQ
What is the function of this protein?
Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity).  In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity).  LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity).  Acts as a LCN1 receptor and can mediate its endocytosis (By similarity).
What are the official names of this protein?
Protein LMBR1L, Lipocalin-1-interacting membrane receptor, LIMR.
What is the protein family that this protein belongs to?
Belongs to the LIMR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CPSF5_DICDI
Sequence: MSIKTLTLYNFNTSYSFGKEEKKEKEQSLTSKLARLKDSYEKEGLRKAVEGIIIIHDHGHPHILLLQDNNYFKLPGGKLKPGENEIDGLIRKLTKKLSPTGTPVSDAPWEIGDHVSTWWRPNFEPSLFPYIPSHITKPKECKKLFVVTLPEKCKFAVSNNLSLIAVSLYEIYNNSQRYGAVISSIPALISRYTFVYLNVD
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing.  The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA.  Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function.  Binds to chromatin.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 5.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. CPSF5 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ANM7_RAT
Sequence: MKVFCGRANPTTGSLEWLEEDEHYDYHQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDKGQKALVLDIGTGTGLLSMMAVTAGADFCYAVEVFKPMAEAAVKIVEKNGFSDKIKVINKHSTEVTVGPDGDLPCRANILVTELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESKRMWSWNKLFPVRVQTGLGEQLIIPPSELERCPGAPSVYDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSKQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPIMQGSPRCLAAHHDDYCVWYSLQRTSPDENNSAYQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYARALRTMLMPGSICLCVSDGSLLSVLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKITVINKRPELLTSADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPQPLWEYPCRSLSEPRQILTFDFQQPIPQQPMQSRGVMELRRPGKSHGAVLWMEYQLTPDSTVSTGLMNPAEDKGDCCWNPHCKQAVYFLSATLDPSAPLDGPQSVSYAVEFHPLTGDITMEFRLADDTLN
What is the function of this protein?
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA.  Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles.  Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s.  Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites.  May also play a role in embryonic stem cell (ESC) pluripotency.  Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
What are the official names of this protein?
Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: CSLG1_ARATH
Sequence: METHRKNSVVGNILHTCHPCRRTIPYRIYAIFHTCGIIALMYHHVHSLVTANNTLITCLLLLSDIVLAFMWATTTSLRLNPVHRTECPEKYAAKPEDFPKLDVFICTADPYKEPPMMVVNTALSVMAYEYPSDKISVYVSDDGGSSLTFFALIEAAKFSKQWLPFCKKNNVQDRSPEVYFSSESHSRSDEAENLKMMYEDMKSRVEHVVESGKVETAFITCDQFRGVFDLWTDKFSRHDHPTIIQVLQNSETDMDNTRKYIMPNLIYVSREKSKVSPHHFKAGALNTLLRVSGVMTNSPIILTLDCDMYSNDPATLVRALCYLTDPEIKSGLGYVQFPQKFLGISKNDIYACENKRLFIINMVGFDGLMGPTHVGTGCFFNRRAFYGPPYMLILPEINELKPYRIADKSIKAQDVLSLAHNVAGCIYEYNTNWGSKIGFRYGSLVEDYYTGFMLHCEGWRSVFCNPKKAAFYGDSPKCLVDLVGQQIRWAVGLFEMSFSKYSPITYGIKSLDLLMGLGYCNSPFKPFWSIPLTVYGLLPQLALISGVSVFPKASDPWFWLYIILFFGAYAQDLSDFLLEGGTYRKWWNDQRMLMIKGLSSFFFGFIEFILKTLNLSTPKFNVTSKANDDDEQRKRYEQEIFDFGTSSSMFLPLTTVAIVNLLAFVWGLYGILFCGGELYLELMLVSFAVVNCLPIYGAMVLRKDDGKLSKRTCFLAGNLHVGSYCVKLLRPQVTSPLRLIHNNNTSGWFKRKKHNMNESV
What is the function of this protein?
Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
What are the official names of this protein?
Cellulose synthase-like protein G1, AtCslG1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like G subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RAGP1_MOUSE
Sequence: MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAEDAKDVIKEIEEFDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADKAELEKLDLNGNALGEEGCEQLQEVMDSFNMAKVLASLSDDEGEDEDEEEEGEEDDEEEEDEEDEEDDDEEEEEQEEEEEPPQRGSGEEPATPSRKILDPNSGEPAPVLSSPTPTDLSTFLSFPSPEKLLRLGPKVSVLIVQQTDTSDPEKVVSAFLKVASVFRDDASVKTAVLDAIDALMKKAFSCSSFNSNTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVRQDYFPKALAPLLLAFVTKPNGALETCSFARHNLLQTLYNI
What is the function of this protein?
GTPase activator for RAN.  Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:18305100).  Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity).  Required for postimplantation embryonic development (PubMed:8314081).
What are the official names of this protein?
Ran GTPase-activating protein 1, RanGAP1.
What is the protein family that this protein belongs to?
Belongs to the RNA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase (PubMed:26506250). Detected at the nuclear envelope during interphase (PubMed:9442102, PubMed:9456312, PubMed:26506250). Shuttles between nucleus and cytoplasm (PubMed:26506250). Targeted to the nuclear pores after sumoylation. During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity).