PharMolix/UniProtQA huggingface dataset:
Protein: LUXF_PHOLE
Sequence: MTKWNYGVFFLNFYHVGQQEPSLTMSNALETLRIIDEDTSIYDVVAFSEHHIDKSYNDETKLAPFVSLGKQIHILATSPETVVKAAKYGMPLLFKWDDSQQKRIELLNHYQAAAAKFNVDIAGVRHRLMLFVNVNDNPTQAKAELSIYLEDYLSYTQAETSIDEIINSNAAGNFDTCLHHVAEMAQGLNNKVDFLFCFESMKDQENKKSLMINFDKRVINYRKEHNLN
What are the official names of this protein?
Non-fluorescent flavoprotein, NFP, FP390.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: SSRP_RHILO
Sequence: MNQVRKADPNNKTVAENRKARFSYEVLDTIEAGLVLTGTEVKSLRQGQANIQDSYASVEGGEIWLINSYLPEYLQANRFNHEPRRRRKLLLNKREMAKLSQSVDREGMTLVPLKIYFNDQGRAKLLLAVGRGKKLHDKRETEKQRDWSREKGRLLKERG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TIAS_HYPBU
Sequence: MSIQEDGLEPMLLAIGIDSFDTPLAGCTTHFTSILAYTLSIHGYRLADYPWLVRLNPAVPWKTRGNGATALLVSVDREDEARRVAEEVTSRLAKAYGSTGKESFVAILLYHADNLQDYITARPHCLVELYRRAVHELVPLKTAMNCLESIREDGKTKLIALHGSTHRGLVGALAALGADLITDHTFELIVYRKPRMWSEPRRIDEDSIIEFDLKTRPLTFLNYDYEQSKPLIAPHGFDPVLYGVRGEEPHILLKALKIIDVEEEPSHWTIFRTNQATNAHLQRKEIERVRPYDNAIVCGVIEDTKPIPGGHVIVRLCNNTCIDTAFYRETGRLRNHVLKLPRGTLVEVGGQVKPHTDKLTLNAEYLRILEPASLRAGGCTATIPSGRNVILYPPRAAFHHLMKPPERPLHPSKSLEPPSTPIHSDTISL
What is the function of this protein?
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
What are the official names of this protein?
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS, tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the TiaS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHPC_BUCBP
Sequence: MVLVTYPAPDFTASAISCNGDIINNFNFKEFTNNQTSILFFWPMDFTFVCPSEIIAFNQELSKFKKRNVKLIGVSIDSVYVHHAWRNTLSHNGQIDKINFTMVSDLKREIQRSYGIEHPQLGVALRATFLIDKNRIIRHQTINDLPFGRNISETLRMIDALHFYEKYGEVCPANWKKGDTGIKTTQEGIHKYLEKISKK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Alkyl hydroperoxide reductase C, Peroxiredoxin, Thioredoxin peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF12_YEAST
Sequence: MSSNPENSGVNANNNTGTGNADAITGAQQNMVLQPRQLQEMAAKFRTLLTEARNVGETTPRGKELMFQAAKIKQVYDALTLNRRRQQAAQAYNNTSNSNSSNPASIPTENVPNSSQQQQQQQQQTRNNSNKFSNMIKQVLTPEENQEYEKLWQNFQVRHTSIKEKETYLKQNIDRLEQEINKQTDEGPKQQLQEKKIELLNDWKVLKIEYTKLFNNYQNSKKTFYVECARHNPALHKFLQESTQQQRVQQQRVQQQQQQQQQQQQQQQQQQQQQQQRQGQNQRKISSSNSTEIPSVTGPDALKSQQQQQNTITATNNPRGNVNTSQTEQSKAKVTNVNATASMLNNISSSKSAIFKQTEPAIPISENISTKTPAPVAYRSNRPTITGGSAMNASALNTPATTKLPPYEMDTQRVMSKRKLRELVKTVGIDEGDGETVIDGDVEELLLDLADDFVTNVTAFSCRLAKHRKSDNLEARDIQLHLERNWNIRIPGYSADEIRSTRKWNPSQNYNQKLQSITSDKVAAAKNNGNNVASLNTKK
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8).  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).  SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation.  SLIK is proposed to have partly overlapping functions with SAGA.  It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 12, TAFII-61, TAFII61, TAFII-68, TAFII68, TBP-associated factor 12, TBP-associated factor 61 kDa.
What is the protein family that this protein belongs to?
Belongs to the TAF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPH_BACTN
Sequence: MIKVEIDEGSGFCFGVVTAIHKAEEELAKGETLYCLGDIVHNSREVERLKAMGLITINRDEFRQLRNAKVLLRAHGEPPETYQIAHKNNIEIIDATCPVVLRLQKRIKQEFRKEDFEEKQIVIYGKNGHAEVLGLVGQTGGQAIVIESAEEAKKLDFTKSIRLFSQTTKSLDEFQEIVEYIKLHISPDATFEYYDTICRQVANRMPNLREFAATHDLIFFVSGKKSSNGKMLFEECLKVNANSHLIDNEKEIDPTLLRNVKSIGVCGATSTPKWLMEKIHDHIQLLIKD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: HPCH_SALEP
Sequence: MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: GATA_FRATN
Sequence: MSYIKKLRARLDSGEISAVELTKEYLAKIKEQDKRINSVITLCEAEALKEAEDADAIISAGKQGLLTGIPILHKDLFCTKGIRTTAASKMLDNFVAPYDSTVTKNCKDQGMVTLGKLNMDEFAMGSTNEHSYYGAVSNPWDLERVPGGSSGGSAAAVAAGFAPISTGSDTGGSVRQPASFCGLTAMKPSYGSTSRFGMVAFASSFDQAGIFAHYAEDVAIMLDAIAGECEFDSTCVGVKENHFTQDLEKDISGKVIGVDESLIKDLPEQIQEAVLKTLDNFKKLGAEIKSVKVPDLKEALSTYYIITPAEAAANLARYDGIRYGYRNPEARDLDELYRKSRTDGFGAEVKRRIMIGNYVLASSQYDSYYNKAQQLRKVMTDQINQIFTQVDVIFMPASPSEAFKKGDKLDPVSAYLSDIYTIPANISGLPAIAFPIGFANNLPVGGQLMAKAFNDNILTQMVVQYQKHYGIEEFILEQARI
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: Y364_MYCGE
Sequence: MDGGQQGSFFGLLVIVIPIILLIVFFSKKKGAQKNDFSGEGGNRSSRKDEVWKTIKQFLQEKNERGKEIIKTFVAKKPNPLHSKKDRKLFNQEIQAYITSNNLGKSEAKRYKNEQTRLMQRELYCIYFVTKDAKSTEVDDARIIEAEVYQKPTKTKSTPERLIRILGLKNFETEMQWIQPLMVREEKRKEKEEQKKLKLAARELKKKKKKKIKKPKEIRNQKNV
What are the official names of this protein?
Uncharacterized protein MG364.
Protein: LGT_NITHX
Sequence: MFLLITYPVFDPVAISLGPIAIRWYALAYIGGIMLGWLYARALLKSEKLWGGPAPISGLQLDDFILWVTIGIILGGRTGYVLFYNLDFFIRHPAEIFEIWKGGMSFHGGFMGCVVAVILFCRKHGLPILSLGDVATAVGPIGLFLGRIANFINSELWGRPADPSLPWAMVFPNGGPLPRHPSQLYEATLEGLVLFTILALMIRAGALKRPGLVLGSFITLYAMARIAGEFFREPDPQLGFLWGGLTMGMLLSAPMIIAGLAIICVAWSRGPRAPVAQTISTPDVSTKADRD
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYDND_ACIBS
Sequence: MMRTHYCGSLTEAQIDQTVTLCGWVHRRRDHGGVIFLDMRDRDGLVQVVIDPDTPEAFATADKARSEYVLKITGRVRRRYEGTENPNMVSGQIEVLGKEIEVLAASETPPFPLNDDTINVSEEHRLKYRFLDIRRPEMLDRLRFRSKVTNLIRNYLDDHGFLDVETPILTRATPEGARDYLVPSRVQNGSFYALPQSPQLFKQLLMVGGIDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFLNDDDIMDLMEGMTVKLFNDLLGVKFEKFRRMPYSEAMRDYASDKPDLRIPLKLVDVADLMQEVEFKVFAGPAKDPKGRIAALRVPGAGSLTRSQIDEYTKFVGIYGAKGLAYIKVNEIEKGIEGLQSPIVKFIEPIVMQLLERVGAENGDIVFFGADKAKIVNDAMGALRVKIGHDLNLATCEWAPLWVVDFPMFEEADDGKWTSVHHPFTLPKSSVEDVKSNPGEALSVAYDMVLNGTEVGGGSLRIYTLEMQKAIFEALGISDEEAEEKFSFLLNALRYGAPPHGGLAFGLDRLVMLMTGATSIRDVIAFPKTKTAECPLTQAPAPVEANQLRDLGIRLREQQKKEA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OGT_MYCPA
Sequence: MIEYRTVDSPIGLLTLAGRDPVLTNLRMVDQTYEPSRTGWTENPRAFAGAVEQLGAYFAGELTEFDIELDLRGSEFQRRVWRALQTIPYGETRSYGEIAEQIGAPGAARAVGLANGHNPIAIVVPCHRVIGASGKLTGYGGGLDRKQTLLALERRHSPASLTLFD
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_META3
Sequence: MDAFDVIKMPIISEKTMKLIEEENKLVFYIDKKATKTDVKNAVKELFDVEVKDLNTLITPKGKKKAYIKLKDEYDAGEVAANLGIY
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DSG3_MOUSE
Sequence: MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFGDDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL
What is the function of this protein?
Component of intercellular desmosome junctions.  Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
What are the official names of this protein?
Desmoglein-3, 130 kDa pemphigus vulgaris antigen homolog.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Protein: RS10_NITMU
Sequence: MQSQKIRIRLKAFDYRLIDKSALEIVETAKRTGAVVKGPVPLPTRIERFDVLRSPHVNKTSRDQFEIRTHLRLMDIMDPTDKTVDALMKLDLPAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RSXD_ECO5E
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQVIFSGHTASGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEQIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHIPLSFLVTLALCATLGWLFSPETLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMPA_ACTP7
Sequence: MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTLLLHNVPNVPADRVLLVGCGKERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGRTSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFNVANRKDLADAERALEHGKAISTGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSRGSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVYGTMKALAEMKLPLNVIGVLAGCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNVLANDLLNAAEQADDKAWRLPLGEEYQEQLKSNFADLANIGGRLGGAITAGQLLSNFTKKYVWAHLDIAGTAWKSGVAKGATGRPVSLLSQFLINKANNQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTP1_YEAST
Sequence: MTAANKNIVFGFSRSISAILLICFFFEKVCGDMEHDMGMDDTSGYTRPEIVQAGSKSFHWLCTLGFLLLLPSVVTCLSFAGRIYSATLLQCTCAVYAFLEAAVLRFQDNDGVENRTSRGTAWFLVGLTWITLFFGGLAGGTGFLVKSKRLQTFISNAGEKRLSYIHRGLSFLTVLTGWVKVCLAPVALFGFCREAHTGQCIAHGIMGSAFVLYGFIYVLVLVIPWIRSAQTSYSQDYVDSWVMCIWGVVNTFTEHRWGREGWSVHDYQHTFMGIIWWTGGILGIFLSRNGRRTFVPSLIIIFTGWAMSEHAQHLIISTKVHNMFGLVLMCGGALRIIEISFLLRDKRTLDKIHSFQYLAPFCLVCSGLLFMGANEEQLILVLRLGGDHSAYVLIIVSGAFLVYFWMIACLEFYLYLLEKGKQGFLPKSYELEEENNNVSFELDNISNEDVDEDTTPFNV
What are the official names of this protein?
Protein YTP1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HEM3_STAHJ
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFVKEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDIVTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSCQVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVGKNPVDLGEAVSRVLKEQGAYEIIKKLNEEQAH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: VU84_HHV7J
Sequence: MRGKKRKTVCKAKGKLTSKSCMCTKANARYTCNCFSKTLPFNEKAIKCTIPEKINSEINISKSEMLLKADKYTNAIYKHSKLRKIFKAVKENLSTTNFATKSKGIVHSNFNDSKPIHSPEIKNYTDFNCDFMHPCGLCSPKNFLSEVYKLLRFYNSTVVQIQVYSRNGLLVNSLHEKLMEIANLIVNKGEQTVSETFFHEQKTAIAINRFLRGTVPHTELTRKEAMMPVNVNSKHRKNSGVYSLYINAPTEKDLFCAAHLCVQFSIRYPADILLNVSKLTQPLLLKEHLIIYNTFNRYIYWDDYGKLLKT
What are the official names of this protein?
Protein U84.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U84 family.
Protein: VP7_ROTA1
Sequence: MYSTECTILLIEIIFYFLAAIILYDMLHKMANSPLLCIAVLTVTLAVTSKCYAQNYGINVPITGSMDVAVPNKTDDQIGLSSTLCIYYPKEAATQMNDAEWKSTVTQLLLAKGWPTTSVYLNEYADLQSFSNDPQLNCDYNIILAKYDQNETLDMSELAELLLYEWLCNPMDVTLYYYQQTSESNKWIAMGSDCTIKVCPLNTQTLGIGCKTTDVSTFEELTTTEKLAIIDVVDGVNHKANYTISTCTIKNCIRLDPRENVAIIQVGGPEIIDISEDPMVVPHVQRATRINWKKWWQIFYTVVDYINTIIQAMSKRSRSLNTSAYYFRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: THIK_ECOLU
Sequence: MPFRSNNPITRDELLSRFFPQFHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPRFAFLRQYRALSQLPACIAPKPHLYLRDWMVVDYLPGEVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRRLKRLRKAREPRPLRLSPLHMDVHAGNLVHSASGLKLIDWEYAGDGDIALELAAVWVENTDQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQTGDQQFIRLADDTWRQLLIKQ
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: RL29_RHOP2
Sequence: MAEMKSGDIRAMSEDQMDDAILNLKKERFNLRFQRATGQLEDTSRLREARRDIARIKTIAAQKRAGKTK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: NUOH_XYLF2
Sequence: MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVRHGPMYVGMGLFQAFADVFKLLFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGVMIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIVAGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNGGWPWLLLKVLFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQKGV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AZOR_CLOP1
Sequence: MSKVLYIKANIKNEGESRTFKVSDSFVEEYKKNNPEDEIITLDLYKENIDFLRADDLGKLFGPKDEESKNNSILKYAYQFADADKYIIAAPMWNLSFPAILKAYIDYVSVSGITFKYTAEGPVGLLNNKKAVHIVSRGGGYDNSPYEMGDRYLRTILGFFGIKDIETIAIDNLDVMGVNVEEKVEEGIEKAISLAKKF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: SSL7_STAA8
Sequence: MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHLYDIKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQENQNHQLFLLGKDKEKYKEGIEGKDVFVVKELIDPNGRLSTVGGVTKKNNKSSETNTHLFVNKVYGGNLDASIDSFSINKEEVSLKELDFKIRQHLVKNYGLYKGTTKYGKITINLKDGEKQEIDLGDKLQFERMGDVLNSKDINKIEVTLKQI
What is the function of this protein?
Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5 (PubMed:15728504).  Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases.  In turn, prevents C5a-mediated neutrophil migration (PubMed:20545943).
What are the official names of this protein?
Staphylococcal superantigen-like 7.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.