PharMolix/UniProtQA huggingface dataset:
Protein: PYRG_COREF
Sequence: MSTSRTTTNNKRHTKHVFVTGGVVSSLGKGLTAASLGQLLIARGLNVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDLGHYERFLNRNLTANANVTTGKVYSTVIARERRGGYLGRTVQVIPHITDEIKARILAMGDPDEHGVVPDVVISEVGGTVGDIESQPFLEAARQVRQEIGRENCFFIHCSLVPYLATSGELKTKPTQHSVAELRSIGILPDALVLRCDREVPEALKTKIALMCDVDTDGVVSCPDSESIYTIPETLYHEHLDTFLIRRLDLPFRDVDWTGWRDLLDRVHHPEREITVGIVGKYVDLPDAYLSVVEAIRAAGYAHRTRTRITWITSDDCTTPAGAATALGGVDALVIPGGFGARGIEGKIAAVTYAREHRIPLLGLCLGLQCVVIEAARQAGLEQATSTEFDPGAAQPVISTMAEQQAAVSGQADLGGTMRLGSYPATLEQGSLVAQLYGITEVSERHRHRYEVNNAYRTQIGQRSPLIFSGTSPDGHLVEFVEYDRAVHPFLVATQAHPEYKSRPTQAHPLFSGLVAAALAAAVTDA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NUOH2_CYTH3
Sequence: MFVVLFVLTLILLYAVFVVWAERKVAAFIQDRLGPMEVGPYGMLQTIADLIKLLQKEDIIATGANRFLFRLAPVLIFTAIFAGFATLPFAPDLIGSKADVGVFFMITIVSLDVVGIFLAGWASNNKFSILGAFRAIAQVISYEIPLTLSILAVVLICQTLDLQEISFQQGIYFVNKQELNTSLFGITSLGIDVNKIGGFVSWNAFKYPFLLLAYVVFFIASLAECNRAPFDIPEGESELVSGFHTEYTGFRFAILFLAEYAMMLLVAFLGVVLFFGSWNTALPNIGSLHFADWTSGTPGTIAGYAWGLFWLISKGITVVFLQLVMRWTYPRLRVDQLMNLCWKILLPLSLFLVIVSGVWVVWMKI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H 2, NADH dehydrogenase I subunit H 2, NDH-1 subunit H 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPT1_DANRE
Sequence: MDCETRGRGRRGRGNRNEESRDVRLSKSLSYVLRHGASKMGLQMNSDGFVFVEELLAHQQFRSFSVDDVERVVASNDKQRFKLCKHPEDDRLQIRANQGHSVQVTDLELREISQDDQDYPREAVHGSYMKHWPSIRSQGLSRMNRTHIHLAPGLPGEGRVISGMRQSCDLAVYIDVTKAMSDGIKFFWSENGVLLTPGDAAGILAPCYFSRAQRLKPLPCDIELH
What is the function of this protein?
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
What are the official names of this protein?
tRNA 2'-phosphotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: SYL_ACTSZ
Sequence: MQEQYRPDLIEAEVQKYWQENKTFKAIKDTNKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVVSRYQRMIGKNVLQPMGWDAFGLPAEGAAVKNNTAPAKWTYENIEYMKNQLKVLGFSYDWEREVTTCRPEYYKWEQWFFTELYKKGLVYKKTSVVNWCPNDETVLANEQVHEGCCWRCDTPVEQREIPQWFIKITDYAEQLLGGLDTLPEWPEMVKTMQRNWIGRSEGVEITFKIENSDETVAVYTTRPDTFYGVSYMAVAAGHPLAERAAQNNPDLAKFIQECKNTKVAEAELATMEKKGMATGLNAVHPITGKPVPIWVANFVLMHYGTGAVMAVPAHDQRDFEFATKYDLPINQVIAPVNGEDIDLSKAAFTEHGKLVNSAEFDGLDFDAAFNGIADKLERMGAGKRQVNYRLRDWGVSRQRYWGAPIPMLTLENGDVVPAPLQDLPIVLPEDVVMDGVKSPIKADPDWAKTTYNGRPALKETDTFDTFMESSWYYARYTCPQYHEGMLDSEEANYWLPVDQYIGGIEHATMHLLYFRFFHKLLRDAGLVSTDEPTKKLLCQGMVLADAFYYTSPTNERIWVSPTKVTLERDEKGRIVKALDDEGRELVHAGMTKMSKSKNNGIDPQEMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGAKRFLGRLWNLVFEYNKNPAKTALNPTALSGVQKALRRGVHKTIAKVSDDIGRRQTFNTAIAAIMELMNKLTRASLAGEQDRAIMGEALSAVVRMLYPITPHVCFQLWKELGNEDVIDFAPWVQADEAAMVEEEKLVVVQVNGKVRGKITVPADMAEDDIKQAALADENVQKFLSGLNIVKTIYVPGKLFSFVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQC_RHOPT
Sequence: MNAMTAFSLNGAAPLANADELEAALRQIGTARYHNLHPFHRLLHGGKLNKGQVQAWALNRYYYQSSIPIKDAVVISRFRDRATRVEWRHRIEDHDGDLGSEGGIERWLKLTEGLGLDSGYVESTQGILPATRFAVDAYVHFVRDRTPLEAIASSLTELFAPNLHEERIAGMLAHYDFVNPEIMSYFKRRLEQAPRDTDFALRYVKQHATTPAEREAVCNALIFKTNVLWAQLDALHHAYVDGHIPPGAFVPQGF
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: SYR_FRAT1
Sequence: MNIENYLSETLAKVFQKLGYAESFAKVVTSTREDVRHFQCNGAMPLAKFAKKPPLAIAEEIVEHIDAEDIFAKLEVAKPGFINITLAPKFLADTTNRFLNSNKFGVQNNLPNRKVVLDFGGPNVAKPMHVGHIRSALLGDALQRIHRFCGDTVVSDVHLGDWGTQMGMLIEEIKLQSPQLVYFDENYTGEYPTESPVTVQELAEIYPRASKRCKSDINEMEKARLATFELQQGRRGYVALWQHFVRISIDAVKKDFDSLDVHFDLWLGESDANKFIDEMISYFQANNFIYEDEGAWVIDTNKDGVPPLIVIKKDGGVMYGTTDLATLWQRSKDLDPDEIIYVVDKRQSLHFKQVFSVAERTKVVSEKCKLKHVAFGTVNGKDGRPFKTREGGVMHLADLISQAKEYAKNRMPDENDDSIINQIAMATIKFGDLINNYANDYFFDLEKFAQHEGKTGPYLLYTVVRAKSILRKIFGDNYDIKSLAKDYKVVNAHNEYEEKLQLQLIQFPIAVQRAYENSQPHHICEYAYSLANSFNKFYVNCPINNLDDESLKKARIALCMATVKAMTIASDLIGISIPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6901_PSEAB
Sequence: MSTQNSAYSAFSSLLAEAAMPVSPAELHGHLLGRVCAGAGFDEAAWQHAAAELLGGAPGERLKAALSGLLGMVRQDFSAGEVAVVMLLPDDETPLAQRTEALGQWCQGFLAGFGLTAREGSLTGEAEEVLQDMAAIAQVQGQLEDSEDGETDYMEVMEYLRVAPLLLFAECGKPLEPAPKPSLH
What are the official names of this protein?
UPF0149 protein PA14_69010.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: DEF_HAEIE
Sequence: MTALNVLIYPDDHLKVVCEPVTEVNDAIRKIVDDMFDTMYQEKGIGLAAPQVDILQRIITIDVEGDKQNQFVLINPEILASEGETGIEEGCLSIPGFRALVPRKEKVTVRALDRDGKEFTLDADGLLAICIQHEIDHLNGILFVDYLSPLKRQRIKEKLIKYKKQIAKS
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RLMC_SALPB
Sequence: MQCALYDAGRCRSCQWITQSVNEQLSAKTADLHRLLAGLPVEQWCAPIGGPEQHFRNKAKMVVSGSVEKPLFGMLHRDGTPVDLCGCPLYPASFAPVFSALKPFIARAGLTPYNVARKRGELKYLLLTESQFDGGMMLRFVLRSETKLTQLRAALPWLRAQLPQLRVITANIQPVHMAIMEGETEIYLTDQQALVERFNDVPLWIRPQSFFQTNPTVASRLYATARDWVGQLPVRHMWDLFCGVGGFGLHCATPQMQLTGIEIAPEAIACAKQSAAELGLTRLHFQALDSTQFAIAQGETPDLVLVNPPRRGIGKPLCDYLAQMAPRFIIYSSCNAQTMAQDIRHLPNYRIQRVQLFDMFPHTAHYEVLALLRRSI
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: VATE_CAEEL
Sequence: MGISDNDVQKQLRHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQQQRQKIMEFFEKKEKQVELQRKIQASNSLNAGRLRCLKAREDHIGAVLDEARSNLSRISGDAARYPAILKGLVMQGLLQLLEKEVVLRCREKDLRLVEQLLPECLDGLQKEWGSTTKVVLDKQNFLPSESAGGVELSARAGKIKVSSTLESRLELIANQIVPQVRTALFGPNPNRSFFD
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Regulates pH homeostasis in the intestine (PubMed:16684534).  Probably by regulating cytoplasmic pH, required for cell survival in the intestine and hypodermis (PubMed:16684534).  Involved in receptor-mediated endocytosis (PubMed:12853134, PubMed:16785323).  Involved in embryogenesis and larval development (PubMed:12853134, PubMed:16785323).
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Apical cell membrane; Peripheral membrane protein. Note=Localizes in clusters in the cytoplasm of the excretory canal (PubMed:12853134). Colocalizes with vha-5 to stacked sheets of the apical cell membrane of syncytial hypodermal cells (PubMed:12853134, PubMed:16785323).
Protein: RL31_ICTPU
Sequence: MAPLKKGGEKKKGRSAINEVVTREYTINVHKRIHGISFKKRAPRAIKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGVRNVPYRMRVRLSRKRNEDEDSPNKLYTLVTYVPVTTYKGLQTVNVDEN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_FINM2
Sequence: MNKLAIIGAQWGDEGKGKVVNYFSQFNDIIVRSSGGANAGHTIYFKDKKYVHHLLPSITFDTDSKGFLAKGMVIELEQMIEELKVLEADFPGISKRFMVDVETFIVLPYHKEEDGLLESMRKNPIGTTKRGIGPAYQDKAARQNVRIIDLFDDELLRERVEEIVYLKNNIYEGKMHIDVDETVNYLLDKFDQLLKLGVTFTSASEIEDEIKNKRVLFEGAQGIMLDLDSGTYPYVTSSTTTAYSASCADVTLTDDDTIMGVVKAYTSRVGEGEFPTELFDEEADKLRKLGNEFGATTGRNRRVGWIDLAQLRYAIKKSKINSIVMTKADVLNGYDKVKVCVGYEIDGVEQKMPFISNDFKKAKPIYKEFDGWNDVFEVNFLKYMTFIEKELDTEISYVSYGPKTEEIMEKRDFIMNIK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_PELTS
Sequence: MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAALVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQKKS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_STAHJ
Sequence: MRILVNISYQGSQFLGFQIQQQGRTVQQQFEKILKRMHRRHVRIHPSSRTDRGVHAYEQFFHFDTDLNIEPKQWKYAMNSALPDDIYVKEVQQVDDHFHCRYDCLGKRYRYKVYQATHRNPFESGLKTFIKEDLNYSKMNEAAKHFIGTHDFTGFCSQKTEVESKVRTLYQSEIIQTDEGFDYVVTGSGFLYNMVRVLVAFLIEVGKGKRHASEVSTLLNEKNRDSVPFTAPAEGLYLEKIYLTEKDLTTDFGDNIKIHRKKSLQND
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: YFEX_ECO57
Sequence: MSQVQSGILPEHCRAAIWIEANVKGEVDALRAASKTFADKLATFEAKFPDAHLGAVVAFGNNIWRALSGGVGAEELKDFPGYGKGLAPTTQFDVLIHILSLRHDVNFSVAQAAMEAFGDCIEVKEEIHGFRWVEERDLSGFVDGTENPAGEETRREVAVIKDGVDAGGSYVFVQRWEHNLKQLNRMSVHDQEMMIGRTKEANEEIDGDERPETSHLTRVDLKEDGKGLKIVRQSLPYGTASGTHGLYFCAYCARLHNIEQQLLSMFGDTDGKRDAMLRFTKPVTGGYYFAPSLDKLMAL
What is the function of this protein?
Has both general peroxidase activity and dye-decolorizing activity.  Can catalyze the oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and the phenolic compounds guaiacol and catechol.  Also decolorizes the anthraquinone dye reactive blue 19 (RB19).
What are the official names of this protein?
Dye-decolorizing peroxidase YfeX.
What is the protein family that this protein belongs to?
Belongs to the DyP-type peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_TRIEI
Sequence: MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEFKGKANSSVSTRVGIKTSIRKIIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISLPMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEKVELIGLAASDEAIAHARKICSGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGSDLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGTIKAIAQLKPDVEVHFISAVTENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADALVFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLAAEITAAAEKAGEKMWRMPLEEKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQGATGYGVRTLVNWILS
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XTH1_SOYBN
Sequence: MGSSSSMWTVCVILASLASAALCANPRRPVDVQFGRNYVPTWAFDHIKYFNGGSDIQPHLDKYTGTGFQPKGSYLFGHFSMYIKMVPGDSAGTVTAFYLSSQNAEHDEIDFEFLGNRTGQPYILQTNVFTGGKGDREQRIYLWFDPTKEYHRYSILWNLYQIVFFVDEVPIRVFKNSKDLGVKFPFDQPMKIYNSLWNADDWATRGGLEKTDWSKAPFIAAYKGFHIDGCEASVNAKFCDTQGKRWWDQPEFRDLDAAQWRRLRWVRQKYTIYNYCTDTKRYPHISPPECKRDRDI
What is the function of this protein?
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: ILVC_BURM9
Sequence: MKVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRRGGASWSKAENAGLAVKEVAEAVKGADVVMMLLPDEQIAAVYAQEVHANIKEGAALAFAHGFNVHYGQVIPRADLDVIMVAPKAPGHTVRGTYAQGGGVPHLIAVAQDKSGAARDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGSKLRAMMPWIAKNKLVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RPD1_ARATH
Sequence: MKLFLRNAFKTLNPKRKLATTILPSINLILVKPFSQSTTIPKKQDRVRDHGYDNYMEVEKKIRKVVKFHSLILSQPNHTIAISLLDTLARRLGLGFKQHEPGAFLLKFPHVFEIYEHPVQRILYCRLTRKALDQIRHEHEAVLDQIPDAVTRLRKLVMMSNTGRIRLEHVRIARTEFGLPEDFEYSVILKHPQFFRLIDGEETRDKYIEIVEKDPNLSICAIERVREIEYRTKGIDAEDVRFSFVVNFPPGFKIGKYFRIAVWKWQRLPYWSPYEDISGYDLRSMEAQNRLEKRSVACIHELLSLTVEKKITLERIAHFRNVMNLPKKLKEFLLQHQGIFYISTRGNYGKLHTVFLREGYKRGELVEPNDVYLARRRLAELVLMSPRKAKVDAELVRYRDGLDDEDDVE
What is the function of this protein?
Involved in pre-arranging the maintenance of the active cell proliferation during root primordium development.  Does not seem to be involved in cell cycle progression.
What are the official names of this protein?
Protein ROOT PRIMORDIUM DEFECTIVE 1.
Protein: DIK1C_MOUSE
Sequence: MARAAGERGRAARCGRWRRGALLAFAAWTAGWVLAAALLLRAHPSVLSERCTDEKSRRILAALCQDYRRGWLTGALCEDLCVGGELLYQRCLYYERGKKVLQAQWRGRTVVLKSKREAFSSFPPLTLLEEEAGAGAPGIPEAELLLMVAGEVKNTLGLELPNNSIAPLWPARQGPGWRQQLASAWSLLQQEEYVYFSLLPDLSRHILPVLGSCGHFYAVEYLAAGSPHHKALFPLDDAGQAQAISHIALSFLDMVSHFDSDFSHRLHLCDVKPENFAIKRDFTVVAIDVDMAFFEPKMREILEQNCTGDEDCNFFDCFSKCDLRVHKCGAQRVNSNLQVICDKIFRHWFSSTHRSPAVSLQLRLQLQQAVQECAQHGGSSGNSWTASSSVFWKLRWLLQATLKELQEAEK
What are the official names of this protein?
Divergent protein kinase domain 1C, Protein FAM69C.
What is the protein family that this protein belongs to?
Belongs to the DIPK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: GEMI6_MOUSE
Sequence: MSEWMKKSPLEWEDYVYKEVRVIACEKEYKGWLLTTDPVSANIVLVNFLEDGRLSVTGIMGHSVQTVETISEGDHRVREKLMHVFASGDCKGYSPEDLEEKRTSLKKWLEKNHIPVTEQGDAQRTLCVAGVLTIDPPYAPENCSSSNEIILSRIQDLIQGHLSASQ
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).
What are the official names of this protein?
Gem-associated protein 6, Gemin-6.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity).
Protein: SNUT1_MOUSE
Sequence: MGSSKKHRGEKEAAGTTAAAGTGGTTEQPPRHREHKKHKHRSSGGGSSGGERRKRSRERGSERGSGRRGAEAEARSGAHGRERSQAEPSERRVKREKRDDGYEAAASSKASSGDASSLSIEETNKLRAKLGLKPLEVNAVKKEAGTKEEPVAADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFEQRRQDLYSARDLQGLTVEHAIDSFREGETVVLTLKDKGVLQDGEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILAKYDEELEGERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLSPEEMVTFKKTKRRVKKIRKKEKEVIMRADDLLPLGDQTQDGDFGSRLRGRGRRRVPEVEEEALEDEEKDPVAQPPPSDDTRVENMDISDEEDGGALPPGSPEGLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVLEIVKKLESRQRGWEEEEDPERKGTIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK
What is the function of this protein?
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome.  May also bind to DNA.  Appears to play a role in hypoxia-induced regulation of EPO gene expression.
What are the official names of this protein?
U4/U6.U5 tri-snRNP-associated protein 1, Hypoxia-associated factor, Squamous cell carcinoma antigen recognized by T-cells 1, SART-1, mSART-1.
What is the protein family that this protein belongs to?
Belongs to the SNU66/SART1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATB_BURO0
Sequence: MATQWEVVIGLETHAQLSTVSKIFSGASTQFGAEPNTQACPVDLALPGVLPVLNRGAVERAIRFGLAIGSTIAPRSIFARKNYFYPDLPKGYQISQYEIPVVQGGQITIQVPANEKAGKPAYEKTVNLTRAHLEEDAGKSLHEDFAGMTGIDLNRAGTPLLEIVTEPEMRSAAEAVAYAKALHALVVWLGICDGNMQEGSFRCDANVSVRPVGQEKFGTRAEIKNLNSFRFLEEAINYEVRRQIELIEDGGEVVQETRLYDPDKRETRSMRSKEDAHDYRYFPDPDLMPLVIGRDWVERVQSGMPELPAAMQQRFVDEYGVSAYDAGVLTSSKAMAAYFESVVAKAGAANAKIVANWLMGDVSSQLNRDGIEIDAIPVSAAQLALLLQRIADGTISNKIAKEIFATIWDEKATDEGAADRIIDAKGLKQISDTGALEAIIDEVLAANAKSVEEFRAGKEKAFNALIGQAMKATKGKANPQQVNELLKKKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: ENO_PROMH
Sequence: MSKIVKVLGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKAVEAVNGPIAKALLGQDAKDQANIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLYEHISDLNGTHGQYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAPTLKEAVRMGSEIFHHLAKVLKAKGMNTAVGDEGGYAPNLESNAAALAAIKEAVEAAGYVLGKDVTLAMDCAASEFYNNETGNYELKGEGKTFTSQEFTHYLEELTKQYLIVSIEDGLNESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIDKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAIISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGSKAPFNGLKEVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SYVNA_XENLA
Sequence: MTGASLALTAAVVAHAYYLKNQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKFMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHFRILALMLLLGVLDAFFVSHAYHSLVIRGASVQLVFGFEYAILMTVILTVFIKYILHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYVAFMTIMVKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATAEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPTQPQTPTEQQNQHQNQAQQQPTPVIPPQPNFPPGILPPFPPGMFPLWPPMGPFPPVPGAPGGNPPDEANPGSSSGSSPRPGETSNVGSESQPGAALPGFPFPPPFLGMPILPPFGLPPMPMPPAGFTGLTDEELRAMEGHERQNLEARLQCLQNIHTLLDAAMLQINQYLTVLASIGPPQPPISSTSTSTSSAASASTAPTTSNISEPVIPVDTTSTVTNTESSQQSAPPAPVSVETLSGAEGGETTTEEPDNVELRRRRLQKLETGTTDSQ
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation.  Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.  Also promotes the degradation of normal but naturally short-lived proteins.  Protects cells from ER stress-induced apoptosis.  Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase synoviolin A, RING-type E3 ubiquitin transferase synoviolin A, Synovial apoptosis inhibitor-1-A.
What is the protein family that this protein belongs to?
Belongs to the HRD1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.