PharMolix/UniProtQA huggingface dataset:
Protein: GSA_NEIMA
Sequence: MNRNEILFDRAKAVIPGGVNSPVRAFGSVGGVPRFIKKAEGAYVWDENGTRYTDYVGSWGPAIVGHAHPEVIEAVREAALGGLSFGAPTEGEIAIAEEIAKIMPSVERLRLVSSGTEATMTAIRLARGFTGRDKIIKFEGCYHGHSDSLLVKAGSGLLTFGNPSSAGVPADFTKHTLVLEYNNIAQLEEAFAQSGNDIACVILEPFVGNMNLVRPSEAFVKALRELTEKHGAVLIYDEVMTGFRVALGGAQSLHGITPDLTTMGKVIGGGMPLAAFGGRKDIMECISPLGGVYQAGTLSGNPIAVAAGLKTLEIIRREGFYENLTARTEQLVQGFRTAADAAGIEFTADSVGGMFGLYFAAHAPRNYADMARSNIEGFKQFFHGMLDRGIAFGPSAYEAGFVSAAHTPELIDETVAVAVEVFKAMAA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_RENSM
Sequence: MSVEVNNESGVELPEAELVRLSRFVFEKLYLHPQTELSIILADREAMEKLHVEWMYEPGATDVLSFPMDELRPGTVSRPAPAGLLGDIVICPQVAQEQAQAGGHSVEDELLLLTTHGLLHLLGYDHEDPEEKAEMFGLQRELLTSFLGRDAPAETTA
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1214_BRUA1
Sequence: MAKKKDTPGDGEFPGFSDTLQRTPKLEKPHYAGHRDRLKQRFRDAPDALADYELLELLLFRAIRRADTKPIAKALLNRFGSIAEVLAAPENLIAEIPGAGPTVALELKLVEAIAKRSARSTVMEREVLGSWDKVINYCTAAMAFETREQFRILFLDKKNKLIADEVQQTGTVDHTPVYPREVVKRALELSATAIILVHNHPSGDPTPSRADIDMTKQLVNAAKALNITVHDHVIIGKHGHASLRSLRLI
What are the official names of this protein?
UPF0758 protein BAbS19_I12140.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: KIT_MOUSE
Sequence: MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAGDTLSLTCIDPDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSIYVFVRDPAKLFLVGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPNPKAGITIKNVKRAYHRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFGSANVTTTLKVVEKGFINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGMLQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGIIVMVLTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSVRVNSVGSSASSTQPLLVHEDA
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  In response to KITLG/SCF binding, KIT can activate several signaling pathways.  Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL.  Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.  Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.  Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.  Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
What are the official names of this protein?
Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Protein: TSAD_BRUMB
Sequence: MRVLGIETSCDETAAAIVERDDMGEGRILSNVVLSQIAEHEPYGGVVPEIAARAHVEALDRLVDRALNDAGLKLYEVDAVAATAGPGLIGGLIVGLMTAKALAMAAQKPFYAVNHLEGHALTARLTDGLPFPYLLLLVSGGHTQMVLVRGIGDYERLGTTIDDALGEAFDKTAKLLGLPYPGGPAVERMALQGDQKRFALPRPLKGEARLDFSFSGLKTAVRQTATELVPLTDQDVTDICASFQAAVADTLSDRVGRSLERFKTEFPDCATPSLVVAGGVAANKTLRAALENLCTRHGFAFIAPPLNLCTDNAAMIAWAGAERAATQAPDSLDIAPRSRWPLDEKSAPVFGTGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1711_LISMF
Sequence: MYLPKEKEIIQIKSYKHNGKLHRTWKKTVVLKSTENIIIGGNDHTLVVEADGRKWVTREPSICYFHSDYWFNVISMIREDGIYHYCNLGTPFAVDEQALKYIDYDLDIKVFPDGRFHLLDEGEYEQHRRQMKYPDSIDRILRHNVDVLSHWILDKKGPFSPDYIDIWYEKYKEYR
What are the official names of this protein?
UPF0374 protein LMOf2365_1711.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: DXR_BACFR
Sequence: MNEIKKKQIAILGSTGSIGTQALQVIEEHPELYEVYALTANNKVDLLIAQARKFMPEAVVIANEEKYAQLKEALSDLPVKVYAGAAALCQIVESGPIDVVLTAMVGYAGLKPTMNAIRAGKAIALANKETLVVAGELINQLARQYRTPILPVDSEHSAVFQCLAGEVGNPIEKVILTASGGPFRTCTMEQLKTVTKVQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPGQIEVVVHPQSVIHSMVQFEDGAIKAQLGMPDMRLPIQYAFSYPDRINSSFDRLDFSKCTNLTFEQPDTKRFRNLALAYESMYRGGNMPCIVNAANEVVVAAFLRDEISFLGMSDVIEHTMGQVSFVQTPTYDDYVATDAEARRIARELICK
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PRB1_TOBAC
Sequence: MGFLTTIVACFITFAILIHSSKAQNSPQDYLNPHNAARRQVGVGPMTWDNRLAAYAQNYANQRIGDCGMIHSHGPYGENLAAAFPQLNAAGAVKMWVDEKRFYDYNSNSCVGGVCGHYTQVVWRNSVRLGCARVRSNNGWFFITCNYDPPGNFIGQRPFGDLEEQPFDSKLELPTDV
What is the function of this protein?
Probably involved in the defense reaction of plants against pathogens.
What are the official names of this protein?
Basic form of pathogenesis-related protein 1, PRP 1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
Protein: ARMD5_ARMGA
Sequence: MPALTYLLLAAIGASTVHSLPSQQSCNAPVTPSSFSSTSLDVVIVGGGTAGLVLASRLSESKKLQVGVIEGGYDRTNDPLIDVPNAANALGYQGAVFGNSTYDWEYTSVPQRGLGGRVLSYPSGKVLGGSSAINGLTIQRGSREDYDAWGNAFGNGPEWTFDALLPYFKRYERWHAPTLSATGDLNSDGLSAVHGTDGRISISYNNFFTGVDIPLTQAGIALGLGPTQNPDGGDDSLFPNFGASHSLDPATGNRSYAANGYYGQTERCRSNLHLLTGAVVTRIIWDKKKATKAVGVEYAVGNDKFTVKASKEVVLSAGSLRSPQILELSGVGNKTLLESLNIPVVVDIPQLGENLQEQFIAGTDFLVRDGVVTLDALGNNATFLAEQQNLYRTNKTGAFTYLSNVNAPTPIRSLVTEDQYKTMRAALDTYLASQTLTPLQIVQYNLVKQFLDGGKVATSSLLVVASGGLVSTPAAGQGYISVVSSPAHPLSRGNVHINTTDPLAYPLIDSAFLTNPWDAQATINVMKFVRRWVAKSDIIESPGTPPQAADEWSDDQWIAYLQSVLGTAHHPVGTAAMASQKLGGVVDPRFKVYGLKNVRIVDASVFPMHIGVAPSSTTYMLAEKAADAIKKDLNAY
What is the function of this protein?
Dehydrogenase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols (Probable).  The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene (PubMed:21148562).  The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (By similarity).  ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (By similarity).  The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (By similarity).  The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (By similarity).  The role of the NAD(+)-dependent enzymes remains unknown (By similarity).  Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (By similarity).  The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (By similarity).  Finally, several halogenase localized outside of the cluster, are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (By similarity).
What are the official names of this protein?
Dehydrogenase ARMGADRAFT_1018426, Melleolide biosynthesis cluster protein ARMGADRAFT_1018426.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: 1003L_ASFM2
Sequence: MGNHLDGSYQPNMVMSIEDKQNKYNEAKERSKVCNKVYINQSGKIDKKELKRIKKLDFFYSQKNDDEIERMFFNMPNGTFLLTDDVTHENIYIAQKDLENGSLNIAKLEFKGEALYINGKNYFFLENYLKTFEDIYKYPLTNFNENK
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 100-3L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 100 family.
Protein: RUVA_MYCPU
Sequence: MLLYRLGKIIHVNKKYIIFESDSAGYTINITRAENFEKDRTLKLYIYELSNEYQKTLYGFTHFKERVLFEDLISINGIGPRIALILLNDGWEKIASLIANGNWETLSRYPYINVKNCHQIIFELQNKWAKFLEKDEKVPSANIQNISDATETLKMLGFKREQIKYALESANLQDDVETLVENAIKKISTVNGKEARN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: YBEY_PSEU2
Sequence: MLELDLQVASETSAPDEARLRLWCEMGLRQRSADSELTIRLVDETEGRELNNTWRHKNYATNVLSFPADVPDDMLDIPLLGDLVICVPVVNREAVEQGKSVDAHWAHMVIHGCLHLLGYDHIDDEEAEEMEALERTLLEELGYPDPYADDESADPPHSDTPSKDHE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1557_XANCB
Sequence: MRGRDEDTGEFRGASRSQQRREALEIFDLGEKLVALTPAQLAKLPVPESLIPHIEESKRITSHIAHKRQLAFLAKHMRREDDETLDAIRDALDANSDTARREVAAIHRVERWRERLLAEGDVALAELLEAYPAADRQQLRQLVRNAIHERAKNKPPRAYRELFQVLRDLSQKPGLESGDAGLEDEESASENDE
What are the official names of this protein?
UPF0307 protein xcc-b100_1557.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: IRO2_ORYSJ
Sequence: MEQLFVDDPAFASSMSSLEADIFSGAGQLPSSPWLDLDLDDDVQDLSMAPTTANAVSSGYGSGGSGSHRKLSHNAYERDRRKQLNELYSSLRALLPDADHTKLSIPTTVSRVLKYIPELQKQVENLERKKKELTTTSTTNCKPGVLGSQLMSEGMAPIVSATCINDMEIMVQVSLLSNVAGSVLPLSKCIKVLENEGLHFISSSTSSGFGNRTFYSIHLQRSEGTINEECPAFCERLEKVVRNKAKL
What is the function of this protein?
Transcription activator that binds to the DNA motif 5'-CACGTGG-3' in the promoter of iron (Fe) deficiency-inducible genes as well as of genes involved in iron homeostasis, thus contributing to basal tolerance to iron deficiency, iron uptake from soil and iron transport, particularly during seed maturation and germination (PubMed:16887895, PubMed:17559517, PubMed:21331630, PubMed:26224556).  Promotes the accumulation of mugineic acid family phytosiderophores (MAs) (PubMed:17559517).  Required for ethylene-mediated signaling during iron deficiency responses (PubMed:21112958).  Improves growth and yield, especially in calcareous soil with low iron availability.  Promotes iron concentration in shoots and grain (PubMed:21331630).
What are the official names of this protein?
Protein IRON-RELATED TRANSCRIPTION FACTOR 2, OsIRO2, Basic helix-loop-helix protein 56, OsbHLH056.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized partially to the nucleus under iron deficiency conditions.
Protein: RL7_LEGPA
Sequence: MAVSKNEILETISNMTVMEVVELIEAMEEKFNVSAAAAAVAVAAPAAGAGAAAAEEQTEFTVVMTSFGSNKVNVIKAIRGITGLGLKEAKDLVEGAPSTVKEGVSKDEAASIKKELEEAGATVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RT109_CANAL
Sequence: MLPPDILQNGEFETIYFQTNPTYIKSPIHIPKSTIGKPDTVKIRHFFALLHQDLVVLGLEVFVYLQIYSDFVEKYVYVSKCDTVGLEKSTIKIGKVIGPVLQYIINYNGYKIKMKNLDEKSKDLSDPSTLVRLQRLRDKLPDIYPNLPYYNDIPPKEECIEYRTLPKTQNLRLCVFTKPAKEYLFPNSAKNPYKNLLNGQSLLRWWISIIDSITKGWNNHKLMIPGADKYATRKFIEKYSDWSEGHIFKKDGLAVQAIPLFPDDPKGRFLELVIVECRYGKMTVSRFYQELAYRQEFLLGDCVSLIGCCKENLEVTYHDDSVSTVTISEYKEFMNSLKSVDFSDRVEVSNFVSNYRKSK
What is the function of this protein?
Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:20601951, PubMed:20080646).  Plays an important role in the regulation of white-opaque genotoxin induced-switching (PubMed:21749487).
What are the official names of this protein?
Histone acetyltransferase RTT109.
What is the protein family that this protein belongs to?
Belongs to the RTT109 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PROA_RUEPO
Sequence: MKDIADISATMTELGKRARAAAAQLAFASAEAKRAALIGAADAVWARRGEIIAANARDLEFGRDKGLSPAMMDRLMLDEARIQGIVDGLRTVADQDDPVGEVLAEWDMPSGIHIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGNAVILRGGSESFHSSGAIHACLVAGLRAAGLPEDAIQLVPTRDRAAVSELLTMTDYVDVIVPRGGKGLVGLVQREARVPVFAHLEGIVHIYIDKAADPEKALRVVMNAKTRRTGICGAAECLLIHKDIADNLGADLVRALIEAGVEVRAEGLPGSLAATEADWGKEYLDMIIAAKVVDDVDAAIAHIRQYGSNHTDCVITEDDAVAARFFERLDSAILMHNASTQFADGGEFGMGAEIGIATGKMHARGPVGAAQLTSFKYLVRGNGTTRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_LACLM
Sequence: MSKRLLILEDGTIFEGEALGANLDVTGELVFNTGMTGYQESITDQSYNGQILTFTYPIVGNYGVNRDDYESIHPTCKAVVVHEAARRPSNWRMQMSFDEFLKSKNIPGITGVDTRAITKIVREHGTMKASLVQARDEVDHQMSQLQATVLPTNQVETSSTATAYPSPNTGRKVVVVDFGLKHSILRELSKRECNLTVVPYNTSAKEILEMEPDGVMLTNGPGDPTDVPEAIEMIKEVQGKIPIFGICLGHQLFSLANGATTYKMKFGHRGFNHAVREVATGRIDFTSQNHGYAVSSENLPEDLMITHVEINDNSVEGVRHKYFPAFSVQFHPDAAPGPHDASYLFDDFMDLMDNFKK
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: DAPA_STAAR
Sequence: MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKELILKTVIDLVDKRVPVIAGTGTNDTEKSIQASIQAKALGADAIMLITPYYNKTNQRGLVKHFEAIADAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTLLSALSVDINPIPIKALTSYLGFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_ECOHS
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TAZ_MOUSE
Sequence: MPLHVKWPFPAVPRLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSTLPVLERLRAENKSAVEMRKALTDFIQEEFQRLKMQAEQLHNHFQPGR
What is the function of this protein?
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (PubMed:19114128, PubMed:21091282, PubMed:21068380, PubMed:23130124, PubMed:26114544, PubMed:30055293, PubMed:30389594).  Its role in cellular physiology is to improve mitochondrial performance (By similarity).  CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity).  Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL.  Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations.  Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate.  Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution.  Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor.  CoA-independent, it can reshuffle molecular species within a single phospholipid class.  Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL.  Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane.  Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes.  Essential for the final stage of spermatogenesis, spermatid individualization (By similarity).  Required for the initiation of mitophagy (PubMed:25919711).  Required to ensure progression of spermatocytes through meiosis (PubMed:26114544).
What are the official names of this protein?
Tafazzin, Taz.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RPOZ_RHOOB
Sequence: MSSTPAVASATPSHGALPAYDTPLGITNPPIDELLARTSSKYALVIYAAKRARQINDYYNQLGDGILEYVGPLVEPGLQEKPLSIALREIHSDLLEHTEGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RPAB2_SCHPO
Sequence: MSDYEEDEAFGMDGAVMEEEVDELEMIDENGQSQQGVSHPGEPSTTVITEDVASSKTAQSGKAVAKEDRTTTPYMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAMKELAQKKIPLLVRRYLPDGSYEDWSVAELI
What is the function of this protein?
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC2, RNA polymerases I, II, and III subunit ABC2, DNA-directed RNA polymerases I, II, and III 15 kDa polypeptide, RPC16.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.