PharMolix/UniProtQA huggingface dataset:
Protein: ACDH_KLEP3
Sequence: MRKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQSDGLARARRMGVATTHEGVGGLMQMAEFADIDFVFDATSAGAHIKNDAALREAKPGIRVIDLTPAAIGPYCVPVVNLAANLHQGNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASIASQSAGPGTRANIDEFTETTSQAIEKVGGAGKGKAIIVLNPAEPPLMMRDTVYVLSELASQEAIAASIAEMAAAVQAYVPGYRLKQQVQFEVIPEDKPVNLPGIGCFSGLKTAVYLEVEGAAHYLPAYAGNLDIMTSAALATAEQMAGAMHSAAGATA
What is the function of this protein?
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A.  Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: SKAP1_XENTR
Sequence: MQGYDIPRDVISLLKDAETYLAECLQNEKLSGRAREQRDEILHSFGQIRNRYGVEFALKGGEAAFTHTGQDDYDDIHNASYAPSQASDEVSVASDYVENDSEVEEELDKIFKQGYLERRKKDHGFFGSEWQKRWCVLTTRAFLYYSSEKGKQPKNGFLIKDSLAQMMPYIRKDSRRDSCFEVVTPNQQVFQFTAASPSDARDWVEQIQFLVKDTQSTIIPYEDDEETYDDIESTESSPVVGLTNDSENSLQEDDVYESIPGDEETEESEDENYEMKPGEPVIFYGDYYQGLWNCFSDNSDELSFERGDLIHILSKEYHAYGWWVGELDGIVGIVPKDYLTLAFDL
What is the function of this protein?
Positively regulates T-cell receptor signaling.  Required for optimal conjugation between T-cells and antigen-presenting cells (By similarity).
What are the official names of this protein?
Src kinase-associated phosphoprotein 1.
What is the protein family that this protein belongs to?
Belongs to the SKAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Protein: SYH_DESVH
Sequence: MSKITKIKGFADLFPPESDVFTRMESVARQVFGRYGFVELRTPILERTDLFCRSIGTETDVVQKEMYTFPDRKDRSLTMRPEATAGVMRAYIESGRHTQEPVSKLFTSGPMFRYERPQKGRMRQFHQINCEVLGPVEPHADAELVLMLMRFLTELGLTGLSLQINSLGCKECRPLYRKALSDFLASIDNAALCEDCRRRMETNPLRVLDCKVPGCRELTANAPTILEHNCPECRTHFDAVLRILDSRNVPYVLNDRLVRGLDYYNRTTFEVVSDSIGSQGSVAGGGRYDGLISQLGGPDVPGVGFACGMERLALMMPGADAPRPHFHVAVLDPAAQDAALLLAEDLRAQGLTGSVGFGAGSIKSRMRLAGKSGARACLILGGDELAAGTVVVKDMDSGEQETIGRDAVAARLLAAGA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_FRASN
Sequence: MTATTAESGNLLPLVSGRSRPPRHLADLSRDERRAVATSLGLPAFRADQLARHYFTHHLRADDADLMTDLPASIRPALVEAMLPRLLTPATALDCDGGQTRKTVWRTVDGAKIESVLMRYPQRATVCVSSQAGCGMGCPFCATGQGGLTRNLSTAEIVEQVVDAARTMAARTTAEGGLPGGPGRLSNVVFMGMGEPLANYAALLAALHRLIDPAPDGLGLSARGLTVSTVGLVPAIRRLAGEGLPVTLAVSLHAPDDELRDELVPINTRWPVAEVLAAAWEYARVTGRRVSIEYALIDGVNDSPERADALAALLVGQLAHVNLIPLNPTGGSSWQASAPRGQRVFVERLRARGVAATVRDTRGREIAAACGQLAAEPPVRSRAGR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_FRATH
Sequence: MVVIRMARGGAKKRSFYRIVVADKRSPRDGRFIEKLGFFNPLAKGGEERLKLDVAKAEAWLAKGAQPSDRVASLIKEAKKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: LCF1_YEAST
Sequence: MVAQYTVPVGKAANEHETAPRRNYQCREKPLVRPPNTKCSTVYEFVLECFQKNKNSNAMGWRDVKEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSFDQLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHSLVQTGSKAIFTDNSLLPSLIKPVQAAQDVKYIIHFDSISSEDRRQSGKIYQSAHDAINRIKEVRPDIKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNVLKFVGNTDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSSVRNCQGDLQEFKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGGGALGNLVFKKIRTATGGQLRYLLNGGSPISRDAQEFITNLICPMLIGYGLTETCASTTILDPANFELGVAGDLTGCVTVKLVDVEELGYFAKNNQGEVWITGANVTPEYYKNEEETSQALTSDGWFKTGDIGEWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAPLTKLAKKLGIMEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGEWTPQNGFVTSAQKLKRKDILNAVKDKVDAVYSSS
What is the function of this protein?
Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids.  Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:8206942, PubMed:11477098, PubMed:12601005, PubMed:27136724).  It may supplement intracellular myristoyl-CoA pools from exogenous myristate.  Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (PubMed:8206942).  Also involved in long-chain base (LCB) uptake of sphingolipids.  In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in active LCB uptake (PubMed:27136724).  Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the shingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490).
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 1, Fatty acid activator 1, Fatty acyl-CoA synthetase, ACS, FACS, Long-chain acyl-CoA synthetase 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Lipid droplet. Cell membrane.
Protein: HXD4_PANPA
Sequence: MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARACSQSDPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: IF1_PEDPA
Sequence: MAKDNVIEIEGTVKETMPNAMFKVELENGHEILAHVSGKIRMHYIKILPGDKVTVEMSPYDLSKGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_DEIRA
Sequence: MSSDPTGRPIETRKLRHLEACLRPESQYQKVKTGLDSVPWPYRALPESNLEEMRLDTVFLGRRLKAPVLIGAMTGGAEKAGVINRNLATAARNLGLGMMLGSQRVMLEHPDAWESFNVREVAPEILLIGNLGAAQFMLGYGAEQARRAVDEVMADALAIHLNPLQEALQRGGDTRWQGVTYRLKQVARELDFPVIIKEVGHGLDAATLRALADGPFAAYDVAGAGGTSWARVEQLVAHGQVHSPDLCELGVPTAQALRQARKTLPGAQLIASGGIRSGLDAARALSLGAEVVAVARPLLEPALDSSEAAEAWLRNFIQELRVALFVGGYRDVREVRGG
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_STAS1
Sequence: MSAIIDAKKQEVDIIAEQLKNSVSTVIVDYRGLSVAEVTELRSQLREAGVEYKVLKNTMVRRAAQQAGIDGLDEFLVGPTAVATSTEDVVAPAKVIAGFAKEHQALEIKTGVMEGNVISAEEVNTVGTLPSHDGLVSMLLSVLQAPVRNFAYAVKAVGEDKESKEESAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DF110_ARATH
Sequence: MAITKKNLIAFVFTILFVISYVHCRSTSDIVSGSGIKEDEHVCFKTSPCLPEVGGEKGCIAFCSRMKFTTGLCLGSVVCCCYT
What are the official names of this protein?
Putative defensin-like protein 110.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1500_SYNY3
Sequence: MLTVYTQSDQALSWIERHGHCPPVFVCVLGFTETGLIPGISAAGKTPADRKLTAIADAEFLIKGTTAGATYPLPPLISGVSPVFITKALVDALHTPVYLFNSGLPIPPAVPVINLDGQPARCLSTGQALPLALVEHLFQQGLQWGAQLAQEHAESYLVLSECVVGGTTTALGVLLGLGIDAGGKVNSSHPHCNHQQKLALVRQSLEHHSPHLNAMEVVAAVGDPMQMVVAGMAIAASHSTGVMLAGGTQMLAVYALIQALTRQQNLAVDFSRLVVGTTKWVCEDASGDTVGLANLLAPVSLLAPQLSFSSSVYPQLQVYEQGFVKEGVGAGAMAIAAHLYKNWGQEQLLELIENLITRELGQVKEKKQQ
What are the official names of this protein?
UPF0284 protein sll1500.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: RECA_CERS4
Sequence: MDKAKALESALAQIERQFGKGSIMKLGANSPVMEIEATSTGSLGLDIALGIGGLPKGRIIEIYGPESSGKTTLTLHVVAEEQKKGGVCAFVDAEHALDPQYAKKLGVNLDELLISQPDTGEQALEIVDTLVRSGAVNLIVVDSVAALTPKSEIEGDMGDMQMGSQARLMSQAMRKLTASIGRSNCMVIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRTGAIKDRDNVIGNTTKVKVVKNKVAPPFREVEFDIMYGEGISKTGELVDLGVKAGVVEKSGSWYSYGDERIGQGRENAKAFLRANPTVAGDIEDRIRASHGLDFSTGEDGKGDDLVDM
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRD_SHEB2
Sequence: MSDAKELKQVLTGPIVNNNPIALQVLGVCSALAVTSKLETALVMALALTAVTAFSNLFISMIRNHIPSSVRIIVQMTIIASLVIVVDQLLQAYAYQISKQLSVFVGLIITNCIVMGRAEAYAMKTPPMMSFMDGIGNGLGYGAILLAVGFVRELFGNGSLFGVEILHKISDGGWYQPNGLLLLPPSAFFLIGVLIWIIRTYKPEQVEAKG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METI_ECOLI
Sequence: MSEPMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTVSAIVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTRK
What is the function of this protein?
(Microbial infection) Probably transports the toxic C-terminal region of CdiA from E. coli strain MHI813 across the inner membrane to the cytoplasm, where CdiA has a toxic effect.  Toxin transport is strain-specific, mutations in this gene do not confer resistance to several other tested CdiA toxins.
What are the official names of this protein?
D-methionine transport system permease protein MetI.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MALF_ECOL6
Sequence: MRKNPMDVIKKKHWWQSDALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKIYNFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKESATQPEGERANLRVITQNRQALSDITAILPDGNKVMMSSLRQFSGTQPLYTLDGDGTLTNNQSGVKYRPNNQIGFYQSITADGNWGDEKLSPGYTVTTGWKNFTRVFTDEGIQKPFLAIFVWTVVFSLITVFLTVAVGMVLACLVQWEALRGKAVYRVLLILPYAVPSFISILIFKGLFNQSFGEINMMLSALFGVKPAWFSDPTTARTMLIIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDRLGTTTPAGYTDLLVNYTYRIAFEGGGGQDFGLAAAIATLIFLLVGALAIVNLKATRMKFD
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Maltose/maltodextrin transport system permease protein MalF.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KYNU_BURM9
Sequence: MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRLAPLIGAADDEVAITDTISINLFKLLAAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQLDRDYELRLIDDPADLPDALDDETAVAMITHVNYRTGYMHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVWVPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFVALVESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILDTEAWRAPEFATRAAVT
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: ATPE_GLOVI
Sequence: MALQIKIVAPNKVVFDDQVDEVVLPSVSGQLGILTNHAPLITGLSNGVMRVRKQGTFIPIAVLTGVAEVDNNEVSVVAMAAELGSGIDVDRARAALARAEQTLATSQNKTELLQAQTALERANARLRAAGAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BIOF_THEYD
Sequence: MSEKFFEIFEKKLEKLKEQNLYRSVKDMESRHGMEITIQGKKYINFASNDYLGLSQHPLVKEAGIDAIKTFGAGGGASRLLSGGTILHRKLEELLSEFKNTESCLILNSGYTANTSLIPALAGENDIIFSDELNHASIIDGCRLSRAEKIIYKHADIEDLKKLIRNISCKGKKVIITDTVFSMDGDIAPIRELYELCKAEGALLYIDDAHGTGVLGNGYGILKHLGLQTEAFVIQMGTLSKAIGVFGAFVCGDSSIIDWFINSARGFIFSTSLPPSTVASAYASLKIIMEDKELIKRLWQNIEKVMEIIKNLELKTTKTQTPIIPILFENIEQAIKASRILYDSGIYAPVIRPPTVKTPRIRITITAGHSDNDIEKLSGALTLLNSIF
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: NUDK_SALPA
Sequence: MSQTITLIKDKILSDNYFTLRNITYDLTRRNGEVIRHKREVYDRGNGATILLYNSTKKTVLLVRQFRVATWVNGNQDGMLIETCAGLLDNDEPEVCIRKEAIEETGYDVGEVRKIFELYMSPGGVTELIHFFIAEYHDSERASIGGGVEDEEIEVLELPFSRALEMVRSGEIRDGKTVLLLNYLQTSHLMD
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: DNAJ_STAA9
Sequence: MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRB3_BRUSU
Sequence: MTTAPQESNARSAGYRGDPIFKGCTRPAMLFGVPVIPLVIVGGSIVLLSVWISMFILPLIVPIVLVMRQITQTDDQMFRLLGLKAQFRLIHFNRTGRFWRASAYSPIAFTKRKRES
What is the function of this protein?
The VirB system could be required for the establishment of the replication niche in the host.
What are the official names of this protein?
Type IV secretion system protein virB3.
What is the protein family that this protein belongs to?
Belongs to the virB3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RR2_MARPO
Sequence: MKQKSWNIHLEEMMEAGVHFGHQARKWNPKMAPYIFTERKGIHIINLTQTARFLSEACDLVANASSKGKQFLIVGTKYQAADLIESSALKARCHYVNQKWLGGMLTNWSTIETRLQKFKDLENKKKTGTINRLPKKEAANLKRQLDHLQKYLGGIKYMTSLPDIVIIIDQQKEFTAIQECITLGIPTICLVDTDCDPDMTDIPIPANDDARASIRWILNKLTLAICEGRYNSIKN
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TMCO1_CANLF
Sequence: MSTMFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS
What is the function of this protein?
Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (By similarity).  In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity).  Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528).  Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261528).
What are the official names of this protein?
Calcium load-activated calcium channel, CLAC channel, GEL complex subunit TMCO1, Transmembrane and coiled-coil domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TMCO1 family.
Protein: PDXB_SHESP
Sequence: KLKDKTVGIVGAGNTGSAVAKCLQAYGVTVLLHDPVIQDSDPRDFISLDELIACCDVISLHVPITKTGEHKTWYLFDEARLNSLKQGTWLLNCCRGEVIDNQALIKVKLERPDIKLVLDVWEGEPNPMHELIPLVELATPHIAGYSLEGKARGTFMLYQKLMQVLGKDADKSMTALLPSLWSVQLDVESIPDQKSLLQLARFIYDLRDDDELFRKTILDDSSKNPQVNSLNNNGFDLMRKNHLHRREFSALRLVNTGHSDVNWLTNLGFSGIGQ
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_BORA1
Sequence: MQTIPLPIRPTAGRWRTADVVALYELPFPELLHRAQSVHREHFDATEIQLSSLLSIKTGGCPEDCGYCSQSARHDSGLAAEKLMPLDEVLAEARAAKNAGAQRFCMGAAWRSPKPHHLEAVAEMVREVKALGLETCVTLGMLQDGQAEQLKEAGLDYYNHNLDTSPEFYGNVVTTRGYQDRLDTLARVRNAGIHVCCGGIIGMGESRRDRASLIAQLANMEPYPESVPINHLVPIPGTPLAEAAPVDVFEFIRTIAVARITMPRAKVRLSAGRQSMSEAEQALCLLAGANSIFYGASLLTTGNPQVQADRALMSKLGMRPETV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: KDPA_STAHJ
Sequence: MSIVLFLIVFILLSLIVSRYLYSVALNVPSKIDVVFNPIEKLIYRLIGTNLEHMSGKTYIKHFLLFNGLMGGLSFVLLLIQQWLFLNPNHNLNQSVSLAFNTMASFLTNTNLQHYAGETGLSYLTQMCVITFLMFTSAASGYAVCIAMLRRLTGMTDVIGNFYQDITRFIVRVLIPFALIISLFLISQGTPQTLKGNLVIETLSGVKQTIAYGPMASLESIKHLGTNGGGFLGANSSTPFENPTYWSNYAEALSMMLIPGSLVFLFGRMLKTKQQIHPHAIMIFVAMFVMFIGFLVTCLYFEFAGNPELHHLGIAGGNMEGKETRFGIGLSALFTTITTAFTTGTVNNMHDSLTPLGGMVPMVLMMLNAVFGGEGVGLMNMLIYVMLTVFICSLMIGKTPSYLGMKIEGKEMKLIALSFLVHPLLILVFSALAFIVPGASDALTNPQFHGVSQVLYEFTSSSANNGSGFEGLGDNTVFWNISTGIVMLLARYIPIVLQILIVSSLVNKKTYQQHTQDVPINNLFFSSVLIIFIILLSGLTFLPDLMLGPIGEQLLLHV
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.