PharMolix/UniProtQA huggingface dataset:
Protein: UPP_BRUA4
Sequence: MGVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRDLELTTMPIETPLMPMDAPVLEGKKLVFASILRAGNGLLEGMLDLVPAARVAHIGLYRDHDTLQPVEYYFKAPEDIVNRLIIVVDPMLATGHSAIAAIDKLKERGATNIRFLCLLAAPEGIKRFTEAHPDVDVFTASIDERLDEKGYIVPGLGDAGDRMYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: 5HT2C_PANTR
Sequence: MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDERKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores.  Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.  Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress.  Plays a role in insulin sensitivity and glucose homeostasis (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, Serotonin receptor 2C.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM3_CROS8
Sequence: MLDNVLRIATRQSPLALWQAQYVKQRLEACHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELELAMLDGRADIAVHSMKDVPVEFPEGLGLVTICEREDPRDAFVSNQYKSLDEMPAGSIVGTSSLRRQCQIAARRPDLIIRSLRGNVGTRLSKLDNGDYDAIILAVAGLKRLQLDARITSPLAPEISLPAVGQGAVGIECRLDDTRTRELLAPLNHEETAVRVRAERAMNTRLEGGCQVPIGSYAELRDGELWLRALVGAPDGSRIVRGERRGAPEDARQLGISLAEELLNHGAREILADVYQGDGPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ADD_CLOPS
Sequence: MNLLNLPKIELHCHLDGSLRVETAIELAKKEGIKLHSYEYDKVKELLVISKECNSLEDYLNRFALPAKLLQRPENLERVAFELMEDASKENVKYIEIRFAPLLHLEKGMTQKEVIESVIKGIRKAEEFYDIKGNLILSCLRHHSIDSVYEVIEEGKNFIGKGVVAIDLAGGELEGFVKPYKEVMKLARESGFRVTIHAGETGYGKNVRDAIELLGAERIGHGLFIFNDEEAYNLVKEKGVTLEMCPKSNIDTKGVNKYEEHPIYKYHKDNIRVNLSTDNRTVSNINLTEEFENVHKTFNIDFEDYKKIYLNSVEASFCSEELKEKLKLSIII
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: Y349_METJA
Sequence: MAVAYAKLYELILKKVKDEKEAEELYNAIIEIVKEEKLAVKTELKDELRGELATKEDIKYLDGKIEMVKKELEYKLIIHTLIILFAIIITNPNAIELIKLLFGFK
What are the official names of this protein?
Uncharacterized protein MJ0349.
What is the protein family that this protein belongs to?
Belongs to the M.jannaschii MJ0023/MJ0349/MJ1072/MJ1074/MJ1107/MJECL16 family.
Protein: 6PGD_HUMAN
Sequence: MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1A_SCHCO
Sequence: MGKEKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYMVTVIDAPGHRDFIKNMITGTSQADCAILTIAGGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDTTKWSEDRFNEIVKETSTFIKKVGYNPKTVAFVPISGWHGDNMLEESTNMPWYKGWTKETKAGVVKGKTLLDAIDAIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPSNVTTEVKSVEMHHEQLAEGKPGDNVGFNVKNVSVKDIRRGNVASDSKNDPAKEAASFNAQVIVLNHPGQIGAGYAPVLDCHTAHIACKFAELLEKIDRRTGKSLEASPKFVKSGDACIVKLVPSKPMCVESYNEYPPLGRFAVRDMRQTVAVGIIKSVDKTDKSGGKVTKSAEKAAKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTC_BIOTE
Sequence: MCDEDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTASTSSSLEKSYELPDGQVITIGNERFRCPEAMFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMFPGIADRMQKEITALAPPTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ARGP_ECO57
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVSSKPFAEKYFPNGVTRSALLKAPVVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLDYGHKVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RL11_BURL3
Sequence: MAKKIIGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAFADKSFTFVMKTPPATVLIKKAAKVDKGSSKPHTDKVGSITRAQAEEIAKTKMPDLTAADLDAAVRTIAGSARSMGITVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: UGPC1_RHIL3
Sequence: MAPISIRGVKKNYGKTPVVHGVDLDIQSGEFIVILGPSGCGKSTLLRMIAGLEEITGGEIAIDGRVVNQLEPRERGCAMVFQNYALYPHMSVAENIGYALKVAGVSKAERQRRIGEVAKALSLEPFLERRPAALSGGQRQRVAMGRAMIREPKVFLFDEPLSNLDAKLRIAMRAEIRRLHRRLGATSIFVTHDQTEAMTLADRLVVMNGGRVEQVGTPEEVYHHPVSRFVAGFVGTPAMNLLEGTINDEGVFVYDQSRKVALPRERAAPLKGKRVVLGMRAEAARLVAPDAPGALTATADFIEELGASRIVHADFDGLPFAVALTEAVKVKSGDPIGIAIDYDQIHLYAADTGRIIENPVMNNAGAVHA
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
sn-glycerol-3-phosphate import ATP-binding protein UgpC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HBL_PSEMZ
Sequence: VFEIAPSAK
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: HTPG_CUPPJ
Sequence: MSAPHETMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDATDKLRFEAIANPSLLENDADLAIRIEADTAARTLKITDNGIGMSRDEAIRNLGTIARSGTKEFFQQLSGDQQKDAALIGQFGVGFYSAFIVADKVTVETRRAGVAADEAVRWESTGDGEFTVDAITRAERGTTITLHMREGEDDFLSAWRLKSIIQKYSDHISLPIRMPKEVWDADTSAYKRTDEWESVNQASALWTRPKSDITDEQYIAFYQHIAHDNEAPLSWTHNRVEGRSEYTQLLYIPARAPFDLWDRNHKHGLKLYVKRVFIMDDAEQLLPSYLRWVKGVIDSADLPLNVSRELLQESRDVKAIREGSTKRVLSMLESLADSEEEAERAKYTTFWQQFGQALKEGLGEDNANQERIAKLLRFASTQNDNAEQSVSLAAYVGRMKEGQDKIYYVTADTWAAAKNSPHLEVFRKKGIEVLLLTDRVDEWMLSFLREFDGKELVSVARGDLDLGSLADEAEKAEQEKAETEWKDVVARAKTVLEGKAKDVRVTLRLTASASCLVSDEGDMSGYLQRLLKQAGQKAPDAQPILELNPEHALVKKLRDLPEGDGFNDRLLVLFDQALLAEGGMLDDPAAYVQRVNKLLA
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMN6_SHEDO
Sequence: MAFTFKQFHIDDGQCAMAVSTDGVLLGAYAPLTQAKSVLDIGAGSGLLSLMAAQRTQADCQIVAIELDQNAANACQNNVNNSPWSKRIKVVNSSIQAYCDDLASLSSQVDNQTAAITPTSKFDYIISNPPFFENGPSSQSPERAAARHTHNLPFSALFNAIKSLLSPLGLSTIILPVQSLESATLAYQEAGLKLSCQRFIASVQGKSPYRVILCLQHLSAGDILLALGAGKSLNPLSETSLFIRDNQGQFGPEMASLCKDFYLKL
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPI1_ARATH
Sequence: MEIATVVKANGGCEADRRRLRRLRCSVKDYDWGKIGSDSLVYRVYAANSDYEIDPTRPYAELWMGTHESGPSYLEDADGSNGVTLRSWITENPKSLGNRVLEKWGCDLPFLFKVLSVARPLSIQAHPDKKLAKKMHKAHPNLYKDDNHKPEMALAYTQFEALCGFIPLQELKSVIRAIPEIEELVGSEEANQVFCITEHDEEKVKSVVRTIFTLLMSADADTTKKIVSKLKRRLHMESQERQLTDKERLVLKLEKQYPNDIGVISAFFFNYVKLNPGEALYLGANEPHAYLFGECLEVMATSDNVVRAGLTSKPLDIQTLCSMLSYKLGYPEILKGTRIRPYITRYLPPFEEFEVDLCDLPSGASTVFPSVPGPSLLLVLQGEGRMSTEASADGISMGDVLFVPADTEIHLRSSSDLKLYRAGINSRFLFPL
What is the function of this protein?
Phosphomannose isomerase involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.  Involved in the ascorbic acid (AsA) biosynthesis.  Required during the endosperm development.
What are the official names of this protein?
Mannose-6-phosphate isomerase 1, Phosphohexomutase 1, Phosphomannose isomerase 1, PMI1, Protein MATERNAL EFFECT EMBRYO ARREST 31.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
Protein: PR5K_ARATH
Sequence: MVEGFSLSLMFLLVSHFFVSGVMSRNFTIENKCDYTVWPGFLTMTTAVSLPTNGFSLKKGESRVINVPPSWSGRLWGRSFCSTSSTGNFSCATGDCGSGKIECSDSGARPPTTLIDFTLDATDGQDFYDVSVVDGYNLPLVVVPQRLGSGRTCSNVGCVVNLNKTCPSELKVMGSSNKEHPIACMNACQKFGLPEFCCYGEYGKPAKCQPTLYSTNFKNECPLAYSYAYDNENNTFRCSNSPNYVITFCPNDISSMSQPSKETNGGTKQKSSWKLKLIVGVSAALTLMILIVVVIIVRTKNMRNSEWNDQNVEAVAMLKRYSYTRVKKMTNSFAHVLGKGGFGTVYKGKLADSGRDVAVKILKVSEGNGEEFINEVASMSRTSHVNIVSLLGFCYEKNKRAIIYEFMPNGSLDKYISANMSTKMEWERLYDVAVGISRGLEYLHNRCVTRIVHFDIKPQNILMDENLCPKISDFGLAKLCKNKESIISMLHMRGTFGYIAPEMFSKNFGAVSHKSDVYSYGMVVLEMIGAKNIEKVEYSGSNNGSMYFPEWVYKDFEKGEITRIFGDSITDEEEKIAKKLVLVALWCIQMNPSDRPPMIKVIEMLEGNLEALQVPPNPLLFSPEETVPDTLEDSDDTSTFFNPSHFERGTLLDSEDVLQHGSRSS
What is the function of this protein?
Possesses kinase activity in vitro.
What are the official names of this protein?
PR5-like receptor kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ACSF_PARMW
Sequence: MVPPTAVAEANAVATKDPVKDTILTPRFYTTDFDDMAAMDLRPNEAELEAICEEFRKDYNRHHFVRNDDFDGAADKLDPETRRVFVEFLEQSCTSEFSGFLLYKELSRRIKQQNPLLAECFAHMARDEARHAGFLNKAMSDFGMQLDLGFLTANKDYTFFQPKFIFYATYLSEKIGYWRYIAIYRHLEKNPESKIFPIFNFFENWCQDENRHGDFFDALMKSQPDTVRGPIAKLWCRFFLLAVFATMYVRDVARKEFYEALGLDARTYDKMVIEKTNETTARVFPVVLDVNNPKFWTRLERLVENNAALEAADRSSSPAPLKLFKKLPRWISNGAEMAKLFLMSPIDSAKFQPAVR
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, Mg-protoporphyrin IX monomethyl ester oxidative cyclase.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
Protein: CHEG_CHAGB
Sequence: MFPALQKIVVSTNASPLVGRELASNSTWIWHVERLPMLLGIPTVILSLTPAVLRLLIKPLLFVPIRYSSFVLTRLITPVLKEDMLEFESTADKKSPAGPKAKGKLALTSWLLSRYPASLKDRMSQLIRDYLAITFESTPSTSGVLFYILIELAAAPELAEAVRRELREVAPNGELPSTHLNELKVMDSVMRESARVNPFSHLVLYRKLLRPLKLEGCPELPAGCFICVDAHHIDFSPQLWENPERFDGLRHYRARQKPENGNRFKFANLGSDAPGWGDGPQACPGRMFADNTIKIILAHILTHYDLELPPGQGKPEKGSMPNGSMSPDTKAKVLFRSRKL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536).  Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C. globosum (PubMed:33622536).  The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317).  Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317).  Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317).  Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317).  The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317).  Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317).  The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase cheG, Chaetoglobosin A biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: 5057R_ASFK5
Sequence: MFSLQDLCRKNTFFLPNDFKKHTLQLLGLYWKEHGSVHRAEKDNIMIQNELILTVNDALQLAGEEGDTDVVQLLLLWEGNLHYAIIGALKAENYNLICEYHSQIEDWHALLPLIQDPETFEKCHELSLGCDLLCLLQHAIKCNMLSILVKYKEDLLNARIRHRIQSLFVLACETRRIEIILWIGQNLPIPEPETIFSIAVITKDLELFSLGYKIIFDYMQRQGIFQLSEVVRKILLNRHIDMAVNKGLLPFVLETFKYGGSVKRALSCAVMDNKRKVIDYLVRHENISHQTIERLLYLAVKKHSSRKTLNLLLSYINYKVKNIKKLLDHVLGGNSTLVLKILLEKKQNLVDAALTRLVKHSTYFRVKEFIEDFSISPEKFIKIAVREQKNVIIKVICEDIWENPAERIRYLKQIVSSIKYESGRQFLINIIHTIYQSHSLKPEEIFKLATFYVKHNAVTHFKDLCKFLWLNRGTESKKHFLKCLEIADEKDFPAIKSIVSEYINYMFTAGTMTKDEIMQAYASEYTMC
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.  Interferes with host NF-kappa-B promoter activity mediated by TLR8.  Mechanistically, inhibits the phosphorylation and subsequent nuclear translocation of host NF-kappa-B RELA subunit downstream of TLR8.  Promotes the expression of the autophagy-related protein host ULK1 to degrade host STING and inhibit the interferon response.  Inhibits also JAK1- and JAK2-mediated signaling and thus negatively regulates the IFN-gamma signaling.
What are the official names of this protein?
Protein MGF 505-7R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RS21_ECO8A
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RL2_ALKEH
Sequence: MALVKAKPTSPGRRFVVTVRNKELHAGAPYEPLVEKKTRKGGRNNTGRITTRHRGGGHKQRYRVIDFRRDKDGVPGQVERLEYDPNRSANIALVLYRDGERRYIIAPRGVSAGTEIVSGVDAPIKPGNALPLRNIPVGTQVHCVELRPGKGAQLARSAGANAQLVAREGRYATVRLRSGEMRQVLAECKATVGEVGNSEHALRSLGKAGAKRHKGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGVPTKGHKTRSNKRTDKFIVRRRKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: KAD_DESPS
Sequence: MGKNILFFGPNGSGKGTQGAIVQKKYDIPHIESGAIFREHIGGGTELGLKAKEYIERGDLVPDEITIPMMVSRLQKDDCKKGWILDGFPRSKVQAITLAETLAKEGMALDYVIEIVLDRDIAKERIMGRRLCVNDNNHPNHIAFEAIKPVEKDGKLVCRVCGGDLKTRPDDQDVNAINKRHGIYYDEETGTMAAVNYFKNANGPKVISIDGSASIGEVTELIMKEL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_ECOSE
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAF1A_BOVIN
Sequence: MLEEPECGAPGARGEAAAMDCKDRPAFPVKKLIQARLPFKRLNLVPKEKIDDGLDDTGGSRAGPVQTQLHNLETSLDHLENCHMGSDIDFRPKLVNGKGPLDNFLRSQVETSIGQAVVIIDLTEDSSNPPDNMVGHNKLNSAASSAQKNINGVPDKAGDDRGLPKARQKDELASPEEALSEVPCKTEAGGADSGGADRRGLTQRGSPQNCPKLTGDLSMWSEKDRDGWSEAGGILFKGKMPVVVLQDILALRPPARSPPATPPSQAVPSESETPESSPEEDLALSHSSLSSSSPTSSPEGQSVPTKLHTGPSPFPASTPVCRITKKLVRGSAEKNKMKLQRDKERLRRQLKLRAEKEEKEKLREEAKRAKEEARKKREEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRTAFDQDLCDQLDQLLQQQSSEFSFLQDLKSRRPLRSGPTVVSNRNTDLSNSDVVIVESSKVDGVPERRKFGRMKLLQFSENHRPAYWGTWNKKTTVIRPRDPWAQDRDLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRILQPVKIGCIWAADKDGGADLKVLQQFTACLLETVPPEEEQTPKASKREKRDQQILAQLLPLLHGNVNGSKVIIREFQECCRRGLLSRDAGSPEDSAASPPSPGPARPQTPTASEDVAVPSKARLKRIISENSVYEKRPDFRMCWYVHPQVLKSFAQEHLPVPCQWSYVTAVPSATREDSGSVPAPGPGQGMPVSLKRKSAGSMCITQFMKKRRHDGQVGTGDLDDFQADTEEEDDDEGDCVIMDISDVGDIQAPCGTTSGAGGSVGMDTSESFVSPSSLRLS
What is the function of this protein?
Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair.  Assembles histone octamers onto replicating DNA in vitro.  CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.  It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.
What are the official names of this protein?
Chromatin assembly factor 1 subunit A, CAF-1 subunit A, Chromatin assembly factor I p150 subunit, CAF-I 150 kDa subunit, CAF-I p150.
What is the protein family that this protein belongs to?
Belongs to the CHAF1A family.
What are the subcellular locations of this protein?
Nucleus. Note=DNA replication foci.
Protein: PFDB_METAC
Sequence: MTSELPPQIQNQIAQLQQVQQQVQALAMQKSQIEAMQKESKMALEELEKLADDAVVYRNVGELVIKTSKEESVSKLKDREETLSLRLQSISRQEERLTTRFKQLQEQIQQALGPKAQ
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_THEP1
Sequence: MVRIRLTRMGKRHQPFYRIVVVDSRKRRDGAYIESLGYYNPLKEGEIKIDVERAVEWILKGAQPSDTVRDIFRKFGVMKRVHEIKYGKKEEATAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HBBA_BOSJA
Sequence: MLTAEEKAAVTAFWGKVHVDEVGGEALGRLLVVYPWTQRFFESFGDLSTADAVMNNPKVKAHGKKVLDSFSDGMKHLDDLKGTFAALSELHCDKLHVDPENFKLLGNVLVVVLARNFGKEFTPVLQADFQKVVAGVANALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-A, Beta-A-globin, Hemoglobin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.