PharMolix/UniProtQA huggingface dataset:
Protein: GLPG_ECODH
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LITAF_CHICK
Sequence: MSAPSGFPAPSAPPSYEETVGINVNYPHPYPVPQPGLRPDGKGMNPPQYSGQPMPTSTPVTVQTVYVQQPVVLFYDRPVQMSCPSCNQMIVTRLCYESGALTWLSCGGLFLLGCIAGCCLIPFCVDALKDVEHFCPNCNAHVGSYKRL
What is the function of this protein?
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation.  May also contribute to the regulation of gene expression in the nucleus.  Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
What are the official names of this protein?
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, LPS-induced TNF-alpha factor homolog, Small integral membrane protein of lysosome/late endosome.
What is the protein family that this protein belongs to?
Belongs to the CDIP1/LITAF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane. Late endosome membrane. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane. Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).
Protein: RL17_CHLTB
Sequence: MQHARKKFRVGRTSSHNRCMLANMLKSLIHNERIETTLPKAKELRRHADKMITLAKKNTLAARRLAVGRLMVRYNTLTSKEARQVKAGDLSAYNVDRRVIGKLFDVLATRFSSRNGGYTRILKLQNRVGDNAQKCIIEFLA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: LST2_DROVI
Sequence: MDTFRKWLNKPKADDKSLLARFYHADRSLTAVASELDSFDGRAEPDRCTRLVSRLRQNQDKVLAITNLIMEELLGEERDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSILNRESESKEMRPLAQAVTKSLSNVRVLLRDQCLRNNVPNSKTLHLDFNDSTTEQLYESLKIFDHLFAEFELSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRALKIGLLDQDMVDAFDPGLMFSIPRLAIVAGLVIYAKGPLNMDMPGDELSEMFRPFRTILIKIRDLLRNLSKQELYQLEKLLCTNEEINTKVPLGYSSIEAPSPEPNSSNNHNNNNSNSSDSGSAKTSTTSPHKAVERLVDHRNNNNSSSCSASAATQAVARSPSMLSLSAGSTPTASPAPSPTPSHSIASTSSAATTSTNPPANWSEDDDDDDEEREDDEEECGMLDSDEQDLNDDSDSDVDEYIEAQLKAIVAAADCASGYLIPNTNLGNLLQPQTAPLTDNFVASEDDEFGAEQEQEQQQRQREEQLQPSSEQQEEPSTSAAMLAARRTLQRLRLPSSSSENEQTTGSNQQSTIKTPNGGGQPMRSGSQRQRHHSHHHHHRHHHHHHHHRQHHHQQQHQPAQAEQHSHHHHHQTHPHRTSRSARKRCSQEHWESTTAEQQQTIDHGHGLASADTSNASSFSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLINMSSSQEDIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFNMGNGNGGGTNAARHSAGAAMQRNNTIDLSGGGYNNNNNNNNNSGSSSSSNSSTVARSHVARSRSLGDQEAATSGTLQEEQRQQQQQQQAQLQLQMQRQRNNSVGSNSPSSSSSSSSSSEHNSPISTRSGSRRRLHSNSASMPSIGSTATTAAATAAATATTTTSATTTTTTTTMSPPAWIPDGKAPRCMSCQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRECYVREVRSSRTQAHSQASRPQAASAS
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: YIIE_ECOLI
Sequence: MAMNTVFLHLSEEAIKRLNKLRGWRKVSRSAILREAVEQYLERQQFPVRKAKGGRQKGEVVGVDDQCKEHKE
What are the official names of this protein?
Uncharacterized protein YiiE.
What is the protein family that this protein belongs to?
Belongs to the YiiE family.
Protein: PUR7_PEDPA
Sequence: MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQLVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEFFYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEFGKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEVHG
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: AHL14_ARATH
Sequence: MDPNESHHHHQQQQLHHLHQQQQQQQQQQRLTSPYFHHQLQHHHHLPTTVATTASTGNAVPSSNNGLFPPQPQPQHQPNDGSSSLAVYPHSVPSSAVTAPMEPVKRKRGRPRKYVTPEQALAAKKLASSASSSSAKQRRELAAVTGGTVSTNSGSSKKSQLGSVGKTGQCFTPHIVNIAPGEDVVQKIMMFANQSKHELCVLSASGTISNASLRQPAPSGGNLPYEGQYEILSLSGSYIRTEQGGKSGGLSVSLSASDGQIIGGAIGSHLTAAGPVQVILGTFQLDRKKDAAGSGGKGDASNSGSRLTSPVSSGQLLGMGFPPGMESTGRNPMRGNDEQHDHHHHQAGLGGPHHFMMQAPQGIHMTHSRPSEWRGGGNSGHDGRGGGGYDLSGRIGHESSENGDYEQQIPD
What is the function of this protein?
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
What are the official names of this protein?
AT-hook motif nuclear-localized protein 14.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_GLOC7
Sequence: MNRVVVGLSGGVDSSTAAASLHHQGYDVVGLTLWLMKGKGQCCSEGMVDAAFICEQLGIPHHIVDSRDVFEKNIIDYLVSGYEVGITPLPCSQCNRAVKFGPMLNYARQELGIDRIATGHYARIGYDEVSGRYQLLRAVDRNKDQSYFLYDLTQDLLAATLFPLGNQTKEETRRIAHEFGLKTADKPESQDLCLIEAHGSMQEFLDKYIKQKEGDIVDLKGKVLGKHKGIHHYTIGQRKGLGVAAPEPLYVVKLDPIMNRVIVGNRADAGQSECNVSRMNWVSIPDPSTPIQTEAQVRYRSFPVRVNVIPLGDNRITLVFDEPQFGITPGQAAVLYQGDILLGGGIIEK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_PSYCK
Sequence: MLASQVVSSVVKPSWFARPTCVVAADLIGKVLCRELTDSDGQQKILRMRISETEAYIGEGDAACHAHAGTRTPRTEIMYHIGGVFYVYLTYGIHHMLNLVSGPTESPEAVLIRAGFLIEGSARLMNEQLLDVNRQLNHIKQLAGPGKLTKGLQIDRTLYGKPITPASKVWVEDDGCQPLVSLRPRIGIDYAGDAKEWLLRYIWTDHPSLSKK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: CLT3_ARATH
Sequence: MATTSRRFTTGLFASITSVKSHSANRPQSISLIRRNHIDHRLPLIVPSSRRWIIQAARSWDGFDDGAEAEIKKPGAYGYAIGDNEIEGSSSSTVHVIDGEHVKTAEIVIWAAVTAAFGVGNRVMYKLALVPLKEYPFFLAQLSTFGYVAVYYTILYFRYRAGTVTDAMLSVPKSPFLIVGILEALAAAAGMAAAANLSGPSTTVLSQTFLVWQIFFSIIFLGRRYSVNQILGCTLVALGVIVSVASGSGAAHSLNEAGVLWILLMVLSFLLQGAGTVLKEVIFIDSQRRLKGASLDLFIVNSYGSAFQAICIALLLPFLSKLWGIPFNQLGTYLKDGAVCFLNNGTITKGCDGAPFLPLLFVIMNIGYNIALLRLLKISSAVVSCLASTVSVPIAVFLFTMPLPYLGVASSLPKGFMGGTIILVLGMILYSWTPHGANSSHTDSVIPSPPPT
What is the function of this protein?
Involved in thiol transport from the plastid to the cytosol.  Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC).  Exhibits some functional redundancy with CLT1 in maintaining the root GSH pool.
What are the official names of this protein?
Protein CLT3, chloroplastic, CRT-like transporter 3, Chloroquine-resistance transporter-like transporter 3.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: YFH7_KLULA
Sequence: MLDYDALVDQALQLLEQNINKNYRVCIGIIGPPGSGKSTVAEKLKEKINSRYHDYLAHEHHAEVAVRPLSSAIDLTGDLSVANKELQAEIKAGFYSHVEDNNFKPVQVKESDGSTLIVGRGGLDNAVRIKPLRKEANLSPTKPDIAQIVPMDGFHLSRKHLDHFKDPTVAHLRRGSPFTFDSNNFLQLCKVLSKTCSLDPNYHSTGPETVNEDNTNSLFDNVTNSFIDLPEISFPGFDHAIKDPVADQHTVHKFTRILILEGLYLLLNQENWSLIYDAIASTGAFIFWNIVIDEDVIEQRVAKRHVKSGICLSLEEGIQRFRANDQINGRLIQSQSVRNANKNVKNVYDIRND
What is the function of this protein?
ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.
What are the official names of this protein?
ATP-dependent kinase YFH7.
What is the protein family that this protein belongs to?
Belongs to the YFH7 family.
Protein: HASP_ARATH
Sequence: MGQRVDLWSEVIKSEEEDGDIPKIEAVFQRRKKPDKSSEAVNFGWLVKGARTSSVNGPKRDSWARSLSTRGRESIAVRAYVNNQPQKKAAGRKKPPIPKGKVVKAPDFQKEKEYFRDIDAFELLEESPSPNKSSTWTMGEQVVPEMPHLSTRLEKWLISKKLNHTCGPSSTLSKILENSAIHQESVCDNDAFDSLSLKTPDKSSAGNTSVFRLIPSCDENLAAEDVPVRKIKMESIDLEDELKRLSLTSDLIPTHQDFDQPILDLLSACGQMRPSNFIEAFSKFCEPESIVKIGEGTYGEAFRAGSSVCKIVPIDGDFRVNGEVQKRADELLEEVILSWTLNQLRECETTAQNLCPTYIKTQDIKLCQGPYDPILIKAWEEWDAKHGSENDHPDFPEKQCYVMFVLEHGGKDLESFVLLNFDEARSLLVQATAGLAVAEAAFEFEHRDLHWGNILLSRNNSDTLPFILEGKQVCIKTFGVQISIIDFTLSRINTGEKILFLDLTSDPYLFKGPKGDKQSETYRKMKAVTEDYWEGSFARTNVLWLIYLVDILLTKKSFERSSKHERELRSLKKRMEKYESAKEAVSDPFFSDMLMDQIS
What is the function of this protein?
Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph) and 'Thr-11' (H3T11ph), but not at 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph).  Plays a role in mitotic cell division during plant growth (PubMed:21527018).  Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph), but not at 'Thr-11' (H3T11ph), 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph).  Involved in histone H3 phosphorylation in mitotic cells.  Contributes to organ and plant development, as well as embryonic patterning (PubMed:21749502).
What are the official names of this protein?
Serine/threonine-protein kinase haspin homolog, AtHaspin.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Chromosome. Cytoplasm, cytoskeleton, phragmoplast. Note=During interphase, localized in the cytoplasm and at the nuclear periphery. During prometaphase and metaphase, localized on chromosomes, and around the cell plate during cytokinesis.
Protein: RS9_BURA4
Sequence: MIGNWNYGTGRRKSAVARVFIKAGKGDIIVNGKPIADYFSRETSLMIVRQPLELTNHGQTFDIKVNVTGGGETGQAGAVRHGITRALIDYDATLKPSLSTAGFVTRDAREVERKKVGLRKARRAKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: U512H_DICDI
Sequence: MAIFKSISSISNSTGSMGSSIGASNLNGFASNDNSISCFDGGCGGSGGSGGSGGLAGWSGLSGWGGIGGFNGSCGGSNANIINIDIDIGRRRRCC
What are the official names of this protein?
UPF0512 protein H.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: PP238_ARATH
Sequence: MRRSIATGFASIVKGFHLHSHRHRLQISNPRTAASLSLCGFCFWIRAFSSYRKILRNGLHNLQFNDALDLFTRMVHSRPLPSIIDFTRLLSVIAKMNRYDVVISLFEQMQILGIPPLLCTCNIVMHCVCLSSQPCRASCFLGKMMKLGFEPDLVTFTSLLNGYCHWNRIEDAIALFDQILGMGFKPNVVTYTTLIRCLCKNRHLNHAVELFNQMGTNGSRPNVVTYNALVTGLCEIGRWGDAAWLLRDMMKRRIEPNVITFTALIDAFVKVGKLMEAKELYNVMIQMSVYPDVFTYGSLINGLCMYGLLDEARQMFYLMERNGCYPNEVIYTTLIHGFCKSKRVEDGMKIFYEMSQKGVVANTITYTVLIQGYCLVGRPDVAQEVFNQMSSRRAPPDIRTYNVLLDGLCCNGKVEKALMIFEYMRKREMDINIVTYTIIIQGMCKLGKVEDAFDLFCSLFSKGMKPNVITYTTMISGFCRRGLIHEADSLFKKMKEDGFLPNESVYK
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At3g16710, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CYB_APOFL
Sequence: MTNIRKTHPLLKIINHSFIDLPAPSNISSWWNFGSLLGICLMIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVIVHLLFLHETGSNNPTGLNSEADKIPFHPYYTIKDILGVLMMVSFLMTLVLFFPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALLPFLHTSKQRSLMFRPITQTLYWILVANLLVLTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKWNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RCSC_ECOLX
Sequence: MKYLASFRTTLKASRYMFRALALVLWLLIAFSSVFYIVNALHQRESEIRQEFNLSSDQAQRFIQRTSDVMKELKYIAENRLSAENGVLSPRGRETQADVPAFEPLFADSDCSAMSNTWRGSLESLAWFIGYWRDNFSAAYDLNRVFLIGSDNLCMANFGLRDMPVERDTALKALHERINKYRNAPQDDSGSNLYWISEGPRPGVGYFYALTPVYLANRLQALLGVEQTIRMENFFLPGTLPMGVTILDENGHTLISLTGPESKIKGDPRWMQERSWFGYTEGFRELVLKKNLPPSSLSIVYSVPVDKVLERIRMVILNAILLNVLAGAALFTLARMYERRIFIPAESDALRLEEHEQFNRKIVASAPVGICILRTADGVNILSNELAHTYLNMLTHEDRQRLTQIICGQQVNFVDVLTSNNTNLQISFVHSRYRNENVAICVLVDVSSRVKMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVMNHITANYLPLVVRKQLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRADGDYLSIRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLISMMDGDISVDSEPGMGSQFTVRIPLYGAQYPQKKGVEGLSGKRCWLAVRNASLCQFLETSLQRSGIVVTTYEGQEPTPEDVLITDEVVSKKWQGRAVVTFCRRHIGIPLEEAPGEWVHSVAAPHELPALLARIYLIEMESDDPANALPSTDKAVSDNDDMMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLSDVNMPNMDGYRLTQRTRQLGLTLPVIGVTANALAEEKQRCLESGMDSCLSKPVTLDVIKQTLTVYAERVRKSRES
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals.  The phosphoryl group is then transferred to the response regulator RcsB (By similarity).  Involved in regulation of K30 capsular polysaccharide synthesis.
What are the official names of this protein?
Sensor histidine kinase RcsC.
What is the protein family that this protein belongs to?
Belongs to the RcsC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TYSY_STRPF
Sequence: MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_STRCO
Sequence: MSLLVVGLSHRSAPVSVLERASLNADAQLKLLQDTVAAEPAAEAAVLATCNRIELYADVDKFHAGVAELSTLLAQHSGVGLEELTPYLYVHYEDRAVHHLFSVACGLDSMVVGEGQILGQIKDSLARAQDLHTAGRLLNDLFQQALRVGKRAHSETGIDRAGQSLVTFGLEQLSAGADVEQWARGKKALVIGAGSMSSLAAATLARAGVAEIVVANRTFERAERLALLLEEQYGQRLSEGDDTDVLARAVPMDAVPGELTRADVAVSCTGATGLVLTADSVAATVEGRTGAPAVEDTAVQETAVREAGETPLPGAGSAADENCPLDLSSVSSVPSGFSVMGEAAVAGMDAATLEQHGAWAAGGTAVDRTREAGRSGPEADAELIGALAATATRVGRIPERRRPEPVAEAPRPQPVLFLLDLAMPRDVDAAVHRLAGVRLVDIESLADASADAPMAADVDMVRRIVADEVAAFGAAQRAAHITPTVVALRSMAADVVAGEIARLEGRLPGLDDKHRAEITQTVKRVVDKLLHAPTVRVKQLAAEPGGAGYADALRTLFDLDQETVASVSRAENSTEKNRGPA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PLSX_BRAHW
Sequence: MNLAIDVASGEKPLEELVSGAISALQENKDINLILVGNEKNISKAISKTKYDHNRIDIRHTDEIIDMNESPANGIKHKKNASVLLAARLVREKEADGFFSPGNTGATLAAALTEIGRLKGVMRPPLISTLPKLNGEFCMLDMGANVDCTTDYIVQFAVMGRVFAKRYLKIDNPRVGLLNIGEEDSKGNANTKKSFERLQKMKKINFIGNIEPNDMLKSDSVDVVVADGFDGNIVLKTIEGTASFVVNLLKEEVKKNPVSVMGGLMMKPVFNNLKSKMSSDSYGSAILLGLNGGAFVGHGKTSGVGMKNAVLNMYKFLDAKINEKIAKELYDSGAKRRIF
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TRMB_VIBC3
Sequence: MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIIGSGVFHMATDWENYAEHMVEVMNQAPGFANLATDGDYIPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: HSLU_BART1
Sequence: MCIVFSPRETVSELDRFIIGQNDAKRSVAIALRNRWRRQQLDEPMREEVMPKNILMIGPTGVGKTGIARRLAKLSGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAVSLVREKKRDEIKEKAHMNAEERVLDALVGKTASPATRDSFRKKLREGELDEKEIEIEVADNNSNSASTFDIPGMPGAQMGIMNLSDILGKMGNRTKVRKTTVRDAFKPLIDDESEKLLDQEQIIQEALRVAENDGIVFIDEIDKIATKDGGASAAVSREGVQRDLLPLVEGTTIATKYGQIKTDHILFIASGAFHVSKPSDLLPELQGRLPIRVELNPLTREDLRRILTEPEASLIKQYIALMATEEVHLEITDDAIDALADIAVDLNARIENIGARRLQTVMERVLDEISFTAPDKAGTSFKIDAAYVRKSIGELAADIDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFTPA_MACMU
Sequence: MWLCPLALTLTLMAASGAACEVKDICVGSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPMGPPGDMPCFPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQESILAIGGKVFSTNGQSATFDAIQEACARAGGHIAVPRSPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYPGEPAGRGTEQCVEMYTDGRWNDRNCLYNRLTICEF
What is the function of this protein?
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.  Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
What are the official names of this protein?
Pulmonary surfactant-associated protein A, PSAP, PSP-A, SP-A.
What is the protein family that this protein belongs to?
Belongs to the SFTPA family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Protein: PRIO_CERDI
Sequence: MANLGCWMLVVFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWHKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: DXS_ACIAD
Sequence: MPHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGANLGVIELTVALHYCFNTPHDRLIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGDGAMTAGMAFEAMNDAVAHDADLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSATDAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADPITYHAITKITPVSIAPVKKSPPKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAKQYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPRGAGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIGITVVNMRFVKPLDEQIIRDLAERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLGLPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: NLE1_MOUSE
Sequence: MAAAVVEEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR
What is the function of this protein?
Plays a role in regulating Notch activity (Probable).  Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity.  Required during embryogenesis for inner mass cell survival.
What are the official names of this protein?
Notchless protein homolog 1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.