PharMolix/UniProtQA huggingface dataset:
Protein: COX1_DIDVI
Sequence: MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTIEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGISSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYMLNDMWAKIHFFIMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYTMWNVVSSIGSFISLTAVILMVFIIWEAFASKREVLDVELTTTNIEWLYGCPPPYHTFEQPVFIKA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATG3_MOUSE
Sequence: MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTDKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLESKDSIKLQDCSALCDEEDEEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKADAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A).  The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of ATG8-like proteins.  The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  Preferred substrate is MAP1LC3A.  Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy.  ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.  ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation.  Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
What are the official names of this protein?
Ubiquitin-like-conjugating enzyme ATG3, Autophagy-related protein 3, APG3-like.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC22_ASHGO
Sequence: MIKSTLIFRDDGLPLCSSVDDDTDPSLADQKKKVKVLISRFTPQSANEATLESGAYEMHYVRQQSVVYIVIVERGYPRNLAFAYLADVRHEFEHSYGNEYVKPSVRPYAFVSFDNFLQKTKKIYNDKRVQGNLDQLNSDLLGVKQIMTKNIEDLLYRGDSLDRMSDLSASLRQDSKKYRRSAQKINFDLLLSQYAPVALIGLFFLFLVWWLVFR
What is the function of this protein?
Required for transport from the ER to the Golgi complex.
What are the official names of this protein?
Protein transport protein SEC22.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Protein: YL893_MIMIV
Sequence: MKVVAVNAGFNVTLQMAYPPNDLLVELHNGLNTYGINWWHYFVPSLVNDDTPAGKLFASTLSKLSYYPRSGAHLDSHQSCSCSIGGTVDTELKVIGVENVRVTDLSAAPHPPGGNTWCTAAMIGARATDLILGKPLVANLPPEDVPVFTTS
What are the official names of this protein?
Putative truncated GMC-type inactive oxidoreductase L893.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Virion.
Protein: NANE2_STRPN
Sequence: MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAAEQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIEVIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTLSGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAITRPKEITERFVASLK
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase 2, ManNAc-6-P epimerase 2.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: YDFH_ECOL6
Sequence: MTVETQLNPTPPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISMAQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSDWFSEE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YdfH.
Protein: ISPE_UREPA
Sequence: MKVKSFAKIDLGYSVYKKQKNFTKHDFESIFILVENIYDDIEITKIEKNIDDVHYYNETNEIYVYSRLVHKTLEWIRHTYHIKNHYRINIKKRIPIGAGLGGGSSNAAAIMKYILEFEGIKEINYKDVVNKLGADIPFFLSGYKTAYISDYGSVLEDLTGQFKLNYEVYLMNVNVNTKIVFEKFDDNSWHVIKNNFKTIIKNLKENIVVNIHNDLQEYCFELYPNIKYKYNELLSDGFYTILSGAGSSFIRIKLKNKEDLIINEN
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: EUTC_ECO57
Sequence: MDQKQIEEIVRSVMASMGQTAPAPSEAKCATTTCAAPVTSESCALDLGSAEAKVWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTLALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: NDUV2_DICDI
Sequence: MFRSLLKRTTFLNQLNKSNGFNRNYFKQSTLTRSDALSRHVETEDNNEHTPFDFTQENLVKVEKILAKYPKQYRQSALIPLLDLAQRQNGGWISLRAMDKVAHICGIAPMTAYEVASFYTMFNRTKIGENFVQVCTTTPCMLRGSGEIIKTCKSHLGIQVGETTPDNKFTLVEVECLGACVNAPMMCINDDFYEDLTSASTINLLDQIKNNKPTKIGPQTHRKAAEGPQGKTTLLEPPVGPTCRDDL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I 24 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: SYL_STAS1
Sequence: MNYSHNEIEKKWQDYWEANKTFKTSDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMLGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTKENIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVYRRPMKQWVLKITEYADRLLEDLDELDWPESLKDMQRNWIGRSEGASVAFDVKDYNEQIEVFTTRPDTIYGASFLVLSPEHELVDLITTEDNKDDVEAYQKEAAKKSDLERTGLSKEKSGVFTGAYAVNPLSGQQVPIWIADYVLSTYGTGAVMAVPSGDQRDYEFAKTFDLPIIEVIEGGDMSKEAYTGDGPHINSGELNGLYNEAAIEKAIELLENKNAGTRKVNYKLRDWLFSRQRYWGEPIPVIHWEDGSMTTVPEDELPLLLPETDEIKPSGTGESPLANIDEFVNVVDEATGMKGRRETNTMPQWAGSCWYYLRYIDPDNEQMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLFDLGVVPTKEPFQKLFNQGMILGEGNEKMSKSKGNVINPDDIVKSHGADTLRLYEMFMGPLDAAIAWSENGLDGSRRFLDRIWRLLITEDGSISNKVVNNHSKALDKSYHQTVKKVTEDYNSLNFNTAISQLMVFINDCYKAEEIYKPYIEGFIKMLAPIAPHISEELWSRLGHDETITYQPWPSYDEALLVDDEIEIVVQVNGKVRAKINVSKDIAKEEMEQIALDNEHVKSEIEGKDIKKVIAVPKKLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBX2_HUMAN
Sequence: MADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
What is the function of this protein?
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089).  CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity).  Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate.  Promotes the neddylation of CUL5 via its interaction with UBE2F.  May play a role in protecting cells from apoptosis induced by redox agents.
What are the official names of this protein?
RING-box protein 2, Rbx2, CKII beta-binding protein 1, CKBBP1, RING finger protein 7, Regulator of cullins 2, Sensitive to apoptosis gene protein.
What is the protein family that this protein belongs to?
Belongs to the RING-box family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL18_BORDL
Sequence: MKKVKEAEKRNIKRKKRIRDRIGFGVAERPRVTIFKSNKYFYAQVIDDIVGHTLASVSTIEKELSLNKNISDVKKLGEVLAKRLKDKNISKLIFDRNGYKYHGLIAGFATALREAGIDV
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: 143GB_XENLA
Sequence: MVDREQLVQKARLAEQAERYDDMAAAMKAVTELNEALSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLNLLDNFLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner (By similarity).
What are the official names of this protein?
14-3-3 protein gamma-B.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_THEAB
Sequence: MKLFDKNERVIKKYWKKVNKINKINLESKNLTELINSLKTIKENITPENIDEYIPEVFAIVREVSKRVIGLRPFDVQLIGAMVLHEGKVAEMKTGEGKTLVATMPVVLNALLGKGVHLVTVNDYLAKRDAMWMGPIYLALGLRVGVINTQNKSYEVIWKNEELAKKALNENLSVWPQGFNGEFLEDEAKNKEALEAYQVELKEISRKEAYECDITYGTNTEFGFDYLRDNLVIDLEDRVQRGHFYAIVDEVDSILIDEARTPLIISGPSKTKASDYIRFNQIAKKLVKDKHFTIDEQKKSVILTDEGIEYIEKLLNIENLYDPEHVNKMYFLLNALKAHYLFKKDVDYIIHNGEIVIVDEFTGRLLPGRRYSGGLHQAIEAKEGVKIKEESVTYATITYQNYFRMYEKLSGMTGTAKTEEEEFKQIYGMEVVVIPTHKPMIRIDRDDLIYRTEDEKFEAVVKEIKKRYEKGQPVLVGTTSIEKSERLSKMLSKEKIPHNVLNAKHHEKEAQIVALAGQKGSVTIATNMAGRGTDIKLGPGVKELGGLLIIGTERHESRRIDNQLRGRAGRQGDPGESIFFLSLEDDIIRIFGGEKLEKIMNLVKIEKGEPIYHPMLTKLIERVQKKVESINFGIRKNLLQMDTVLDTQRRAIYSYREYLLSGNIDEHFNDAIDDFIERRLEEFCEKGVCNVEEIKESLKILNISLDKLPDTRNELKEYLKNLLMEKFENKKKELGEDFPKIGKFIALRVIDENWRQYLEEVEHVKEAVSLRAYGQKDPILEFKKETFRMFDEMMAKIFEQTIIYTLNIRKITDEAEKESENELKKINTQHDEFTLVNRKERRVAEKKGKKKLKVKR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: FIBB_LAMGL
Sequence: ATDYDEEEDDRVKVRLDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: RAB3A_MOUSE
Sequence: MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC
What is the function of this protein?
Small GTP-binding protein that plays a central role in regulated exocytosis and secretion.  Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:11598194).  Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity).  Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity).  Stimulates insulin secretion through interaction with RIMS2 isoform RIMS2 and RPH3AL effectors in pancreatic beta cells (PubMed:15159548, PubMed:20674857).  Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity).  Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity).  Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).
What are the official names of this protein?
Ras-related protein Rab-3A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Lysosome. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell membrane; Lipid- anchor; Cytoplasmic side. Presynapse. Postsynapse. Note=Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form.
Protein: DADA_YERE8
Sequence: MRVVILGSGVVGVASAWYLAKDGHDVTVIDRQDGPAQETSAGNAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAIHLDGSASQLRWMWQMLRNCDTSHYMINKSRMVRLAEYSRDCLKDLREDTGIQYEGRQGGTLQLFRTEQQFDNAAKDIAVLDDAGVPYSLLTADQLATVEPALAKVAHKLTGGLRLPNDETGDCKLFTERLAKMAEQAGVKFIFNRSVEKLLVDGDQIAGVLWGDDIIKADAYVVAFGAYSTALLAGLVSIPVYPLKGYSLTIPITNPAGAPYSTVLDETYKIAITRFDDRIRVGGMAEIVGFNTQLEQARRETLEMVVGDLYPDGGNISQATFWTGLRPMTPDGTPIVGRTSLKNLYLNTGHGTLGWTMACGSGQLLADIMSGRRPAILADDLSVSRYSADFRPLNVAPLHDAHPIR
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: RS21_SHEDO
Sequence: MPIIKVRENEPFDVALRRFKRSCEKAGILADVRAREFYEKPTTARKRAKAAAVKRLAKKLSRENARRVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: GSA_CARHZ
Sequence: MPLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYVGSWGPLILGHRHPKVEEALANCLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGTEATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSGALTLGVPTSPGVPANIANNTITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIMDEVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAGTLSGNPLAMTAGIATLTVLKEEGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLCTFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQFEAMFVSLAHSKDDLDKTIEASYKAFKAAAEN
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_CHLPM
Sequence: MQFSSYEDLRPRLLAGEVSCEEVVRVYLERIERHGDDNIYLTVFRDEAIERAAALDRKLREGGEPGRLFGLPMAIKDNISMDGAPLTCASKMLEGYRSVYDATVIRRLFDEDAIFLGKTNMDEFAMGSSNENSAFGPVQNPFDPSRVPGGSSGGSAAAVAAGLCMVALGSDTGGSVRQPAGFCDVVGLKPTYGRISRYGLVAFASSFDQIGVLSHSSMDAALVLGVMAGSDPHDATSSSHAVSDYCSEVSGVSVKGLKIGVPKEFFNEGLNPDVSRVVLARLEELRLQGAELVDITLPKSDHAIAAYYVLVTAEASSNLARYDGARYGYRSAGATDLSSMYVESRTEGFGPEVKRRIMLGTYVLSSGYYDTYYKKAQQVRRVFQDRYREALSRVDVIAGPTSPFPPFGIGAKTADPLEMYLADVFTVPASIVGMPALSVPVGYDGENLPVGMHLICNFFEEGKLLGIARHMQRPVSRLNPAL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: ENO_ECOLC
Sequence: MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: GATAC_DROME
Sequence: MDMTSTAEAAARSWYDSPRLGGGGSSGGGNGGGVSPQTNGLGSAGSSLAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTSDMSAFYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHFHTPLSPWLTSEHKSFAPASAWSMGQFACPQEPQVEHKLGQMGQSHQTTAAGQHSFPFPPTPPKDSTPDSVQTGPSEYQAVMNAFMHQQATGSTSLTDASCALDIKPSIQNGSASGSSGSGTTHTSTPKQREEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGLGGGCLPIGGHLGMGDFKPLDPSKGFGGGFSASMAQHGHLSSGLHPAHAHMHGSWYTGGMGALGASSGLQGGFSTAGSLSGAVVPHSQPYHLGLSSMGTWRTDYT
What is the function of this protein?
Transcription factor that is vital to the development of multiple organ systems.  Binds to the core consensus sequence 5'-WGATAR-3'.
What are the official names of this protein?
GATA-binding factor C, Protein grain, Transcription factor GATA-C, dGATA-C.
What are the subcellular locations of this protein?
Nucleus.
Protein: CZF1_CANAL
Sequence: MSSIPNINWNDPNNGKSNTSRQSQPQPQLPSNVSPPNSRAVPTSGSIGGPQYGSSQFSNEYSRNPNTIGGPPFPLQSNQRGYMPNTGYPVQQTAQQRSGDKLQQVHSQQQQQQQQPLYQQYPPQSVGYLAGDVYNPQHQEYVQMNQLPNQHYNLQQRQQAQGQQLKSQLNEQNAMMSASTQQYPVQDFTNPYPNAQNPAEQQQQQQPLRTQSQQWDGYQSQPLYSAAGNTIPSSIQQQIPPQNLSPSEQQQVKQQQPSPPEQGTKKKPGRKPKLRKLSESSSETPQVPKTASSSSSSPTAVNSGKPITKRSRMGCLTCRQRKKRCCETRPRCTECTRLRLNCTWPKPGTEHKNKPKDQKDDENTIEHAEFGRIKVLRGIVEYRSK
What is the function of this protein?
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states.  These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence.  Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency.  Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state.  Plays a role in cell adhesion and pseudohyphal growth.  Involved in acquisition of drug resistance and acts as a repressor of beta-glucan synthesis, thus negatively regulating cell wall integrity.  Plays a role in adherence, invasion and damage to oral epithelial cells.
What are the official names of this protein?
Zinc cluster transcription factor CZF1.
What are the subcellular locations of this protein?
Nucleus.
Protein: FMT_STRP8
Sequence: MIKLLFMGTPQFSATVLKGLLDNPAYEILGVVTQPDRAVGRKKDIKVTPVKQLALEHGISIYQPEKLSGSQELIEIMGLGADGIITAAFGQFLPTLLLDSVSFAINVHASLLPKYRGGAPIHYAIMNGDKEAGVTIMEMIKEMDAGDMVAKASTPILETDNVGTLFEKLAIIGRDLLLDSLPAYLSGELKPIPQDHSQATFSPNISPEQEKLDWTMSNQEVFSHIRGMNPWPVAHTFLEGQRLKIYEAQLAEGEGLPGQVIVKTKKSLVIATGQGALSLIVVQPAGKPKMSIIDFLNGIGRKLEVGDIIGR
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.