PharMolix/UniProtQA huggingface dataset:
Protein: SSRP1_DROME
Sequence: MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTWGLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAEEDPVDKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMGKDKSGYKDVDFGDSDNENEPDAYLARLKAEAREKEEDDDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDSDASGGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKPSKKKKDSGKPKRATTAFMLWLNDTRESIKRENPGIKVTEIAKKGGEMWKELKDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGGKSSKKRKTEPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPEESEEDSNASDEDEEDEASD
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.  Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U.  The FACT complex is required for expression of Hox genes.
What are the official names of this protein?
FACT complex subunit Ssrp1, Chorion-factor 5, Facilitates chromatin transcription complex subunit Ssrp1, Recombination signal sequence recognition protein, Single-strand recognition protein, dSSRP1.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Nucleus, nucleolus. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Protein: FGF14_HUMAN
Sequence: MAAAIASGLIRQKRQAREQHWDRPSASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
What is the function of this protein?
Probably involved in nervous system development and function.
What are the official names of this protein?
Fibroblast growth factor 14, FGF-14, Fibroblast growth factor homologous factor 4, FHF-4.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUTS2_LACPL
Sequence: MNSKVLNTLEYQQVKQQLAPYLVSATGQQALNELHPMTSVADIQRALDETNDGAEVYRLKGGIPVARLADIKPHMKRLAIGATLNGSELGQVGRVLRTTRAITRFFAELLEDAPENDIRHLFDEVAELVTLPDVTKRLATAIEGDGHITDEASPELSRIRSNIRRTETEIRNQMGHYTRGHDAKYLSDPIITIRNDRYVIPVKAENRSRFGGIVHDQSASGQTLFIEPQAVMAMNDRLRQNQVAEKQEEQRILEELSNLIAPYQDEIINNAAILGHFDFINAKARYAHDMKATEPAVSPQNEVYLRQARHPLIDPRKVVANDISLGTDYQAMVITGPNTGGKTITLKTLGLLQLMAQSGLFIPVEAGSRVGVYNEIFADIGDEQSIEQNLSTFSSHMENIESFLAQIDAHSLVLVDELGAGTDPQEGAALAIAILDAIGAKGTQVVATTHYPELKAYGFNRPDTINASMEFDEETLKPTYRLLVGIPGRSNALDIAQRLGIPQAIVDQARSLTDTDSQDLNAMIADLVTKRKQVEDEQLHLKTQVADSEKLHRQLKSEFNAYQQRKDQLIEDAKVQANTIVEQSKTKADAIISDLRKKQLASGTATVKENELIDAKGALNALEQQPKLKKNRVLRRAKAQHDFHEGDDVLVKSYGQRGVLMRQMGKHEWEVQLGILKMKISDGDLERVKPEEPKRARATVQSAHASHVSPNLDLRGVRYEDAMTQVDRYIDAALLAGYPSVTIVHGKGTGALREGITNYLKSNRQVKSFHFAAPNHGGNGATEVQFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: TIRR_MOUSE
Sequence: MSTTTVPELKQISREEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGGLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKYQLLFALKVLNMMPSEKLAEALASATEKQKKALEKLLPPSS
What is the function of this protein?
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin.  In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus.  Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs).  Binds U8 snoRNA.
What are the official names of this protein?
Tudor-interacting repair regulator protein, NUDT16-like protein 1, Protein syndesmos.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. TIRR subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ERA_LEIXX
Sequence: MTDYRAGFVSFVGRPNVGKSTLTNALVGEKIAITSSKPQTTRRAIRGIMHRREGQLILVDTPGVHRPRTLLGERLNTLVESTLGDVDVIGFCVPADERIGPGDRFINERLDDYPRAKKVAIVTKIDSARKTQVAEQLLAVSALREWEAIVPVSAVNSIQLDTLTTELMRLLPVSPGPLYPDESVTDEGVEDRIAEYIREAVLDGVEDELPHSLAVTIDDLVERDDKDLLEIYANLFVERDSQKAIVIGKGGSRIREVGATAREPIEALLGRHVFLSIRVKVAKDWQRDPKQLGRLGF
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: GUAA_GEOKA
Sequence: MNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTIRAEEIRALNAKGIIFSGGPNSVYDEQAFTCDPAIFELGLPILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLLFHGLPDEQVVWMSHGDLVTAPPAGFAVDATSPSCPIAAMSDERRKWYGVQFHPEVRHSVYGNDLLKKFVFEVCGCRGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHRAIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKDRFLAKLKGVTDPEQKRKIIGNEFIYVFDDEAAKLEGIEFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFELIEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDVLERISTRIVNEVPHVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RPOC_HAEIE
Sequence: MKDLVKFLKAQSKTSEDFDVIKIGLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMPLRDIERVLYFEMYIVTEPGMTDLERGQLLTEEQYLDAEDRWQDEFEAKMGAEAIQDLLKGMDLEAECEKLREELQETNSETKRKKITKRLKLLEAFVQSGNKPEWMVMTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLIAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNRRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLHLHQCGLPKKMALELFRPFIYAKLESRGYATTIKAAKKMVEREEAIVWDILAEVIREHPILLNRAPTLHRLGIQAFEPILIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLTLEAQLEARALMMSTNNVLSPANGDPIIVPSQDVVLGLYYMTREKVNGKGEGMLLQDPREAEKAYRTGEAELHSRVKVRITEYVKNEAGEFDAKTTLTDTTIGRAILWMIAPKGMPYSLFNQTLGKKAISKLINEAYRRLGLKEAVMFADQIMYTGFAYAARSGSSVGIDDMEIPAKKYEIISAAEEEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSQEEVINREGNPEKQASFNSIFMMADSGARGSAAQIRQLAGMRGLMARPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVIVEDDCGTHEGLVMTPLIEGGDEKVPLRELVLGRVAAEDILKPGTEEVLIPRNTLLDEKLCDVLDANSVDSVKVRSVVTCDTDFGVCAKCYGRDLARGHLINQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASAAAKESSVQVKNTGTVHLMNAKFVTNDESKLVLTSRNTELTITDAFGRTKEHYKVPYGAVLSKGDGQEVTAGETIANWDPHTMPVVSEVSGFVKFVDIIDGLTVTRQTDELTGLSSIVVQDVGERATAGKDLRPTIKLVDANGNDIFLPETDVLAQYFLPGKAIVSLDDGAAVKVGEPLARIPQESVGTKDITGGLPRVADLFEARKPKEPAILAEISGIVSFGKETKGKRRLLITPTEGETYEEMIPKWRQLNVFEGEMVQRGDVISDGAETPHDILRLRGVRAVTEYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKAVITKAYDSEFLEGEQVEVARVKIVNRQREAEGKPPVEFERELLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGFAYHQNRHKHRLVDDVVAKLSEEDEATIADEFVMTADDASASLAEMLNMADDAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PPR1C_PONAB
Sequence: MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRVPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH
What is the function of this protein?
May increase cell susceptibility to TNF-induced apoptosis.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 1C.
What is the protein family that this protein belongs to?
Belongs to the protein phosphatase inhibitor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCP1_ARATH
Sequence: MQKLGFPAMKSLDKPRSLSGSANMYSFSNRKPPDSVSSGSFSNLKLTAEKLVKDQAAMRTDLELANCKLKKSMEHVYALEEKLQNAFNENAKLRVRKKEDEKLWRGLESKFSSTKTLCDQLTETLQHLASQVQDAEKDKGFFETKFSTSSEAIDSLNQQMRDMSLRLDAAKEEITSRDKELEELKLEKQQKEMFYQTERCGTASLIEKKDAVITKLEASAAERKLNIENLNSQLEKVHLELTTKEDEVKDLVSIQEKLEKEKTSVQLSADNCFEKLVSSEQEVKKLDELVQYLVAELTELDKKNLTFKEKFDKLSGLYDTHIMLLQKDRDLALDRAQRSFDNLQGELFRVAATKEALESAGNELNEKIVELQNDKESLISQLSGLRCSTSQTIDKLESEAKGLVSKHADAESAISQLKEEMETLLESVKTSEDKKQELSLKLSSLEMESKEKCEKLQADAQRQVEELETLQKESESHQLQADLLAKEVNQLQTVIEEKGHVILQCNENEKQLNQQIIKDKELLATAETKLAEAKKQYDLMLESKQLELSRHLKELSQRNDQAINEIRRKYDVEKHEIINSEKDKVEKIIKDLSNKFDKELSDCKEESKRQLLTIQEEHSSLILSLREEHESKELNLKAKYDQELRQSQIQAENELKERITALKSEHDAQLKAFKCQYEDDCKKLQEELDLQRKKEERQRALVQLQWKVMSDNPPEEQEVNSNKNYSISKDSRLGGSKRSEHIRVRSDNDNVQDSPFVKAKETPVSKILKKAQNVNAGSVLSIPNPKHHSKVTHREYEVETNNGRVTKRRKTRNTTMFEEPQRRRTRATPKLTPQSIAKGTGMTSHARSANIGDLFSEGSLNPYADDPYAFD
What is the function of this protein?
Required for chromosome synapsis and normal fidelity of crossing over.
What are the official names of this protein?
Synaptonemal complex protein 1, Synaptonemal complex central region protein ZYP1a.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSA2_BOVIN
Sequence: MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
Protein: ITA8_CHICK
Sequence: MPRRQPPRPLLLLSALLCAPASAFNLDEEKLTVYSGPPGSYFGYSVDFYIPDPSTVSVLVGAPRANTTQPDIVEGGAVYHCGWPAARCRQIPFDNTNNRKIKVNGTREPIEFKTNQWFGATVKAHKEKVVACAPLYHWRTLKDSPEKDPVGTCYVAIQNFSAYAEYSPCRNSNADPEGQGFCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASIADIITNYSFKDILRKLAHEKQTGVAPPTYDDNYMGYSVAAGEFTGDSEEELVAGVPRGAQNFGYVSIINSSDLTFIQNFTGEQMASYFGYTVAVSDVNNDGLDDILVGAPLFMEREFESKPKEVGQVYLYLQESAFLFRDPQILTGTEVFGRFGSAITHLGDLNQDGYNDIAVGAPFAGEDRRGKVLIYNGYSNGLKTDPSQVLNGAWASQSMPSGFGFTLRGDSDVDKNDYPDLIVGAFGAGKAVVYRARPVVTVNALLILNPMIVNPDNKTCQPPGSPLFVACFTVRVCAAFEGQSISDEIVLKGELQLDSLKQKGAVKRTLFFDYHQSHHYFSIVMERQKKLYCQDFLVYLRDETEFRDKLSPININLNYSLDESHFKDSLLVKPILNYYQRPSVTEQAYILVDCGEDNLCIPDLHLSAVPDKDQLIIGEENCVMLIINPRNDGEGAYEAELHIKIPPEADYTGVERNNKALRVLSCDYKMENETRMVVCDLGNPMVAGANFSTGIRFSVQHFENSDFSINFELQIKSSNKINSTSNLVNLHINITAAAQVQVRGVSHPPQIILPLHNWEPKDEPTKEEEIGPLVEHIYELHNIGPSAINNTVLHVGWPVSSGEEFLLYILHIQTHGPLHCQTSSPINIMQINFAIPQDTPELAAFLYNSTISHYIRRREVAVAEPYRRNSAKILNCTNVKCILISCNVGQLERGKSAALKIRSRLWAETFLQRKNDPYTLSSNVSFKVKNMPYKVQPAKLPEGSIAIRTSVIWSTPNVSFVIPLWVIILAIMLGLLVLAVLTLALWKCGFFDRARPPQDDMADREQLTNNKTTDA
What is the function of this protein?
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures.  It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN.  NPNT is probably its functional ligand in kidney genesis (By similarity).  Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
What are the official names of this protein?
Integrin alpha-8.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein: MIAB_POLSJ
Sequence: MSKKVFIKTFGCQMNEYDSDKMSDVLHAAEGYEPTQNVDEADLILFNTCSVREKAQEKVFSDLGRVKHLKEKGVLIGVGGCVASQEGAAIIQRAPYVDVVFGPQTLHRLPDLLAKRARLNKPQVDISFPEIEKFDHLPPARVEGASAFVSIMEGCSKYCSYCVVPYTRGEEVSRPFDDVLVEVAGLADQGVKEVTLLGQNVNAYRGPMGDTAEIADFATLLEYVSDIPGIERIRYVTSHPNEFTQSLIDAYARLPKLVNHLHLPVQHGSDRILMAMKRGYTAMEYKSTIRKLRAIRPDLAMSSDFIVGFPGETEDDFNKMMKLIDDVGYDTSFSFIYSPRPGTPAAALHDDTPHEVKLRRLQHLQATIDDSVRAISASRLGTVQRILVEGASRKDPTELMGRTECNRVVNFKGQPRLIGQMVDITITQATQRSLRGEVLTRDVAVQA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_MYCGI
Sequence: MGRFSNADGPGDDADEREVTPALTVGEGDIDASLRPRSLGEFIGQPRVREQLQLVLEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLIEGDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGAEAGAEIARRSRGTPRIANRLLRRVRDYAEVRADGVITRDIAKYALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEATTVEEVCEPFLVRAGMIARTPRGRVATAQAWKHLGMTPPAGAGGLGQVGLFE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LTAA_STAAS
Sequence: MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLAFSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLGIAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVVLIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTYATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTLSMIVNIHIVWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPLFGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIANREKAK
What is the function of this protein?
Proton-coupled antiporter flippase that catalyzes the translocation, from the inner to the outer leaflet of the cell membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors lipoteichoic acids (LTA) to the cell membrane.
What are the official names of this protein?
Proton-coupled antiporter flippase LtaA, Lipoteichoic acid protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LtaA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STP1_LISMF
Sequence: MHAEFRTDRGRIRHHNEDNGGVFENKDNQPIVIVADGMGGHRAGDVASEMAVRLLSDAWKETTALLTAEEIETWLQKTIQEVNKEIVLYSESEMDLNGMGTTLVAAIMAQSQVVIANVGDSRGYLLQNHVLRQLTEDHSLVHELLRTGEISKEDAMNHPRKNILLRALGVEGKVEVDTFVVPFQTSDTLLLCSDGLTNMVPETEMEEILKSKRTLSEKADVFITKANSYGGEDNITVLLVERDLTQKGRDAS
What is the function of this protein?
Protein phosphatase that dephosphorylates EF-Tu.
What are the official names of this protein?
Serine/threonine phosphatase stp.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: AOX1_TOBAC
Sequence: MMTRGATRMTRTVLGHMGPRYFSTAIFRNDAGTGVMSGAAVFMHGVPANPSEKAVVTWVRHFPVMGSRSAMSMALNDKQHDKKAENGSAAATGGGDGGDEKSVVSYWGVQPSKVTKEDGTEWKWNCFRPWETYKADLSIDLTKHHAPTTFLDKFAYWTVKSLRYPTDIFFQRRYGCRAMMLETVAAVPGMVGGMLLHCKSLRRFEQSGGWIKTLLDEAENERMHLMTFMEVAKPNWYERALVFAVQGVFFNAYFVTYLLSPKLAHRIVGYLEEEAIHSYTEFLKELDKGNIENVPAPAIAIDYCRLPKDSTLLDVVLVVRADEAHHRDVNHFASDIHYQGQQLKDSPAPIGYH
What is the function of this protein?
Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation.  May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
What are the official names of this protein?
Ubiquinol oxidase 1, mitochondrial, Alternative oxidase 1.
What is the protein family that this protein belongs to?
Belongs to the alternative oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.
Protein: BGL03_ARATH
Sequence: MELTLSLLTIFLLFFALSGRCSDKNDFPEGFIFGSATSAYQWEGAFDEDGRKPSVWDTFLHTRNLSNGDITSDGYHKYKEDVKLMVETGLDAFRFSISWSRLIPNGRGPVNPKGLQFYKNFIQELVSHGIEPHVTLFHYDHPQYLEDEYGGWINRRIIQDFTAYANVCFREFGHHVKFWTTINEANIFTIGGYNDGITPPGRCSSPGRNCSSGNSSTEPYIVGHNLLLAHASASRLYKQKYKDMQGGSVGFSLFSLGFTPSTSSKDDDIAVQRAKDFYFGWMLEPFIFGDYPDEMKRTVGSRLPVFSKEESEQVKGSSDFIGIIHYLAASVTSIKIKPSISGNPDFYSDMGVSMTWTVLGNFSAFEYAVAPWAMESVLEYIKQSYGNPPIYILENGTPMKQDLQLQQKDTPRIEYLHAYIAAVLKSIRNGSDTRGYFIWSFMDLYELVKGYEFSFGLYSVNFSDPHRTRSPKLSAHWYSAFLKGNTTFLGSQGIMQMQSNFSSSASS
What are the official names of this protein?
Beta-glucosidase 3, AtBGLU3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: SPX_LISMF
Sequence: MVTLYTSPSCTSCRKARAWLEEHDIPYKERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKTFQKLNVDLDSLPLQQLFELIQKNPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRRVRTYQLREAQKMVN
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLPA_PYRIL
Sequence: MSIEVVDVRKHEHHFGVYVVKFEDGTERLATKNLTPGKRVYGERLIKWRDEEYREWNPYRSKLAAAIVNGIKFIPIQEGTHMLYLGAASGTTPSHISDIVGERGLIYSVEFSPRVFREFIEKLVDQGRRNVVPILGDARFPYQYAHYVKGVDVVYIDVAQPAQAKILADNADYFLKPGGYVMLVIKAMSIDVTAPATETFKQEINTLKERGFEILETVHLEPYDTAHAMVIAKKK
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: CRCB2_LATSS
Sequence: MTILLVGLGAALGAILRYQLTRIGNHIASEFPLMTFLINLTGSFCLGWLTGSQLSQPVTLFLGVGVLGGYTTFSTLNSELSQLWFRRRYHIFFGYWLLTYGLGLLVAAAGFYAGL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLME_YERE8
Sequence: MSNKKRSASSSRWLQEHFSDKYVIQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRVIACDLLPMDPIVGVDFLQGDFRDELVLKALLERVGDKKVQVVMCDMAPNMSGTPAVDIPKSMYLVELALDMCRDVLAPGGSFLVKVFQGDGFDEYLREIRSLFTKVKIRKPDASRARSREVYIVATGRKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD53_RAT
Sequence: MGMSSLKLLKYVLFFFNFLFWVCGCCILGFGIHLLVQNTYGILFRNLPFLTLGNVLVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLLILLAEVTLAILLFVYEKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCPSGADVQGCYKKGQAWFHSNFLYIGIVTICVCVIQVLGMSFALTLNCQIDKTSQALGL
What is the function of this protein?
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion.  May be involved in growth regulation in hematopoietic cells (By similarity).
What are the official names of this protein?
Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Leukocyte antigen MRC OX-44.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.