PharMolix/UniProtQA huggingface dataset:
Protein: PCR11_ARATH
Sequence: MNLSSNDQPSQGRIKAKDWSTDLCECWMDINSCCLTCWCPCVAFGRIAEVVDRGSTSCGVSGAMYMIIFMLTGYGGSSLYSCFYRTKLRAQYNLKERPCCDCCVHFCCEPCALCQEYRQLQHNRDLDLVIGWHGNMERHARLAASTPSAPPLQAPMSRLV
What is the function of this protein?
May be involved in heavy metals transport.
What are the official names of this protein?
Protein PLANT CADMIUM RESISTANCE 11, AtPCR11.
What is the protein family that this protein belongs to?
Belongs to the cornifelin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AQPZ1_RHIME
Sequence: MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGGHFNPAVSVGLAVAGRMPPASLVGYILAQVTGAIAAAAVLYVIASGKADFQLGGFAANGYGEHSPGGYSLTAALVTEVVMTAFFLLIILGSTHSRVPVGFAPIAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIVWKIVGDDS
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z 1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IRC6_VANPO
Sequence: MNEDGSVCNKILIAFQDNDQIANLKESVLGEVFRLDKANTNHDENIIKGLTWSTKYYEVRYDLYVDTFDDFEEWCKDLISSEYDDLREVLSGIIVIDSYTMEKDKIDQNKLLGQLGSVLQDKFFVFMNTNKDISQDVIDELNDDNSMQLTSDSGNSVEIINYHNVSNLKLNQYNEKIGFERVREIIDTCEWSGGHRVQTVEAKADSTDVDLESVFNRLKEARLKYLEIEDEDEREQFALEISNEFAEFLQ
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: YNIU_AZOVI
Sequence: MITLTESAKSAVTRFISSTGKPIAGLRIRVEGGGCSGLKYSLKLEEAGAEDDQLVDCDGITLLIDSASAPLLDGVTMDFVESMEGSGFTFVNPNATNSCGCGKSFAC
What are the official names of this protein?
Uncharacterized protein in nifU 5'region, ORF6.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: ATPA_XANC8
Sequence: MATTLNPSEISDLIKTRIEAVKLSAESRNEGSVTSVSDGIVRIFGLADVMQGEMIELPNNTFALALNLERDSVGAVVLGDYENLREGDVAKTTGRILEVPVGPELLGRVVNALGEPIDGKGPLGATQTAPVERVAPGVIWRKSVDQPVQTGYKSVDAMIPIGRGQRELVIGDRQTGKTALAIDAVINQKGTGIKCVYVAIGQKASTVANIVRKLEENGALAHTVVVAATASESAAMQYISPYAGCTMGEYFMDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERAARVSEEYVEKFTNGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAVNAGISVSRVGGAAQTKIIKKLSGGIRISLAQYRELAAFAQFASDLDEATRKQLERGQRVTELMKQKQYAPMSIANQALSIYAVNEGYLDEVPVNKLLAFEEGLHAHFANTQGELVSKINTTGGWDNDIEAAFKKGIEEFKTTGSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MDCB_PSEPF
Sequence: MHALNLQPKTITLAERLADLAVDALIDEADLSPKPALVDRRGNGAHTDLHLGLMHASALALWPAFKEMAEAALEFGEIGLPLREAIGRIGREGEQAMLATTHGVNTHRGAIWALGLLVTAAALDTKSTSAGAVTLRAARLALLDDRYAPRPLSHGAQVAQRYGARGAREEAQLGFPSVVQRGLPQLKRSRAAGHGEQNARLDALLAIMTDLADTCVLYRAGEQGLHAMQHGARAVLDAGGSASLTGRRRLHELDQQLIALNASPGGAADLLAASLLLDRIERDGILQGAF
What is the function of this protein?
Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: TSAD_PSET1
Sequence: MRILGIESSCDETGIAIYDDEKGLLAHQLYSQVKVHADYGGVVPELASRDHVRKTLPLIDAAFAQAGCGPEDLDGVAYTAGPGLVGALLVGTSIGRSLAYGWDIPAVAVHHMEGHLLAPMLEENVPEFPFIALLVSGGHTMMVKVAGIGQYEVLGESVDDAAGEAFDKTAKLLGLDYPGGPRLAKMAEQGVAKRFIFPRPMTDKPGLDFSFSGLKTAASITIRENNDDEQTKADIAHAFQTAVIDTLVIKCKRALKQTGIKRLVIAGGVSANTQLRLQLERVMQGMKGQVYYPRTEFCTDNGAMIAYAGMQRLKAGQFATLDMKTKPRWPIDSLEAI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T106C_MOUSE
Sequence: MGSQHSSALTFCQRKKDDNPEDLLADRDQEEAIAQFPYVEFTGRNSITCHTCQGAGYIPAEQVNELVALIPHSDQRLRPQRTKQYVLLSVLLCLLASGLVFFFLFPHSVLVDDNGIKVTKVTFNEQDSLVVLDVTATLKIRNSNFYPVAVTNLFSQVQYMKAVVGSYTTTNVSLIAPRSEHLVNFTVKAEVGGPSSYVYFYCTLPAIRVHNIVIFMRTSVKISYIGHISQSTLETQHYVDCGVNSTAAQSLFLVPRGPHL
What are the official names of this protein?
Transmembrane protein 106C.
What is the protein family that this protein belongs to?
Belongs to the TMEM106 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.
Protein: HIS7_FRASN
Sequence: MARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDLHIDAHHTVEDTAIAFGTALREALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVEPELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNAHHVVEAQFKSVARAMRDAVALDARVAGVPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_ANAMM
Sequence: MVRDSGACVSVALDAMGADLGPEVAIKGADLVLSGAVPCKHKVHLSIYGKESAVLPVLGKYKLVEKNSVFIDTPDAVLCDDRPSFALRHRRKSSMWCAIEDVKKGVVASAVSAGNTGALMAISRYLLGTLQGIDRPAIATVLPSRKGSFVALDLGANAECAPGLLFQFAIMGRAFARAVLGVEHPKVGLLNIGAEDTKGTYNIQEAFALMRDAKQDINFYGYVEAKEAFDGVADVVVADGFSGNIMLKTCEAVAGLTLHILKKEICSSLMGRAAMRILRSCYFKRTSGSALDVRSYNGAVLLGLNGIVVKSHGSADATAFAHAIKEAVCVISQGDMAKEMISEVSNG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: Y5614_BURCM
Sequence: MLRYAIIFFVIAIIAAVFGFGGIAAGAAEIAKILFYIFVVIFLVTLLLGVVRR
What are the official names of this protein?
UPF0391 membrane protein Bamb_5614.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSTT_GLAP5
Sequence: MSNQSLSSKILGGNLVLRIAVGLVLGICLALVSPDAAKSVGVLGQFFVKSLRAIAPILVFVLVMASIANKEVGSDSRLKPILVMYVLGTFVAAVTAVILSYLFPTTLELVTSPEGLAPPQGVGEVLKTVVFNLVDNPLGAITNGNFIGILAWSIGLGIALRHAAPSTKVMLNDISDAVSFVVKVVIAFAPIGVFGLVAETMATNGADAFIGYARLLAVLLGAMAIVAFILNPLLVYWKIRRNPYPLTITCLRESGVTAFFTRSSAANIPVNMGLAKRLGIKEEIYSIAIPLGANINMAGAAITITVLTLAAAYTQGIVPDFSTAVLLSIVASICACGASGVAGGSLLLIPLACSLFNIPNDVAAQVIGVGFIIGVIQDSAETALNSSTDVLFTAAVSMSDEKNN
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_BORBZ
Sequence: MAITYSIGDMLTKLRNASRVGHGSVDLKMSNMNKSILNILKEEGYIKDFNFLEKKGIAFIRVLLKYDNKRNPVINKIDAISTPGRKIYSSYRNMPRIKNGYGILIISSSQGVITGKEAKDKKIGGELICSVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: INSN_SHIDY
Sequence: MICSPQNNTGAPMKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATALLMSDSLNSSR
What is the function of this protein?
Involved in the transposition of the insertion sequence IS911.
What are the official names of this protein?
Transposase InsN for insertion sequence element IS911.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: EF1A_PODAS
Sequence: MGKEDKTHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEARFNEIIKETSNFIKKVGYNPKTVAFVPISGFNGDNMLEASTNCPWYKGWEKEVKGGKATGKTLLEAIDSIEPPKRPTDKPLRLPLQDVYKIGGIGTVPVGRIETGILKPGMVVTFAPSNVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPMGAASFDAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSELLQKIDRRTGKAVEESPKFIKSGDAAIVKMVPSKPMCVEAFTEYPPLGRFAVRDMRQTVAVGVIKKVEKAAAGSGKVTKSAAKAGKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_STRM5
Sequence: MSLTTALTYALPHRLLSSMARSLAYSDDPRVSRWLIDTVTRKFNVNLDEAANPDPRSYATFNQFFTRALKPGARVADADPRSLVMPADGRISQLGRIEAGRIFQAKGQSFTAAELLGSDEDAKPYNDGLYATVYLSPRDYHRVHMPWTGTLRETVHVPGRLFSVGPAAVNGVPRLFARNERLVCHFDTSFGPMVSVMVGALLVSGVETVWSGEEIPAYGDRITRKDYRGQGIQLERFAEMARFNYGSTVIVLLPPGVAEFAPQLGAESPVQLGQALAKLR
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PESC_CANGA
Sequence: MRVKKRNVRGNAKNFITRSQAVRKLQISLADFRRLCIFKGIYPREPKNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKFREHKTFARKLTRALGRGEVSSAKKLEENRSTYKLDHIIKERYPSFPDAVRDIDDALNMLFLFANLPATNQISSRVIRDAQVICNQWLAYVAKERLIRKVFVSIKGIYYQANVKGEEVRWVIPFKFPENIPSDIDFRIMMTFLEFYSTLLHFVLFKLYTDSGLVYPPKIDVEQDKILSGINAYILESQEETSVLNAEVPSDAPDKEAQSIDTKTLAQAMKADSKDKDDNSNDEAPENVEDVELDEFEDHNKNKGDILAQPSKFSSPTATLFEDFVFYVGREVPIEAIEFLILSCGGKVISEAAMDQIEGNTEFDLSKVTHQIVDRPVLKHKVAGRTYIQPQWVFDCINKGELLSANLYLPGVSLPPHLSPWGDALGYDPTKEVESEDESSDSSEESDSEIENEEEDTKPAAITNEDDDEDVEELAAQKELELEASGIAYSKAKDEGLHDDVASKKKRKVTDEDEEEKKLKMIMMSNKQRKLYKKMKYSNQQKEDKIEELKKKKKQLAKKEKTLKKVEKK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: FENR_STRPF
Sequence: MKDKAYDITIIGGGPIGLFAAFYAGLRGVTVKIIESLSELGGQPAILYPEKMIYDIPAYPSLTGVELTENLIKQLSRFEDRTTICLKEEVLTFDKVKGGFSIRTNKAEHFSKAIIIACGNGAFAPRTLGLESEENFADHNLFYNVHQLDQFAGQKVVICGGGDSAVDWALALEDIAESVTVVHRRDAFRAHEHSVELLKASTVNLLTPYVPKALKGIGNLAEKLVIQKVKEDEVLELELDSLIVSFGFSTSNKNLKNWNLDYKRSSITVSPLFQTSQEGVFAIGDAAAYNGKVDLIATGFGEAPTAVNQAINYIYPDRDNRVVHSTSLID
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: LEU3_BUCUE
Sequence: MKKKYRIAVLPGDGIGPEVMQEAYKILNILKDHFLLPLEMKEFNIGGIAIDQEGIALPKNTLLGCENSDAILFGSVGGKKWDYLSIDKRPERAALLPLRKHFNLFSNLRPAKLYADLKYLSPLRSNIIKDGFDILCVRELTGGIYFGKPNGHSKKNDIEYAFDTEVYYDYEISRIAHLAFQLARNRKKKVCSLDKSNVLKSSILWKEIVEKISKNYPDVHLSHLYIDNAIMQIIKDPSQFDVILCSNLFGDIVSDECAAITGSIGMLPSASLNEKNFGLYEPAGGSAPDIAGKNIANPIAQILSVSMLVRHGMNLKKIADKIDESVVSVLKQGYRTADISNNSHNYLKTSEMGDIIANFLINGK
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_SALG2
Sequence: MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVSNDFGYDYIFSRYVEAVGREGDVLLGISTSGNSGNVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_SALEP
Sequence: MKKGIHPNYVEITATCSCGNVIKTHSTVGHDLNLDVCGKCHPFFTGKQRVVDTGGRVERFNKRFSIPGSK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: END4_CITK8
Sequence: MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTAQIIDDFKAACEKYHYSPAQILPHDSYLINLGHPVSEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLQQIPEEECLARIAESINIALEKTQGVTAVIENTAGQGSNLGFRFEHLAAIIDGVDDKSRVGVCIDTCHAFAAGYDLRTTDECEKTFADFERVVGFTYLRGMHLNDAKSAFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTAKVVA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: DYN2_HUMAN
Sequence: MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
What is the function of this protein?
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP.  Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity).  Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:33713620).  Involved in cytokinesis (PubMed:12498685).  Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
What are the official names of this protein?
Dynamin-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction. Membrane, clathrin-coated pit. Postsynaptic density. Synapse. Midbody. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity).
Protein: ANMK_BURM9
Sequence: MTSNRMQTGHPADGVYFGLMSGTSMDGVDGVAVRFEAGKPPAVLSEAFVGFADTLRDALFALQQPGGDEIEREALAANALAARYAVCCHELLRTAGLLPDDVRALGVHGQTVRHRPERGYTRQLNNAALLAELTRIDVIADFRSRDVAAGGQGAPLVPAFHATVFGSPDETRVVCNLGGISNITILPAGGGPQGEGHARNDTVRGHDCGPANALIDAWVERHLKQPFDDGGRFAARGKVDETLLAALLDEPYFRQNAPKSTGRDLFNADWLDAKLAGFQHLAPENVQATLTALTAATVADEIARHAGDCRAVYVCGGGARNPVLLDALATALAARGLDAAVATTAALGVPPQQVESLAFAWLAYRFNARAPGNVSTVTGAAGERVLGALYPR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RL31_PELUB
Sequence: MKKDIHPDYHTIKVEMTDGTQFETRSTWGKEGEVLKLEIDPKSHAAWTGGKQKLMDKGRVSKFNKKFQNFRSEKKD
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RS3_CLOPE
Sequence: MGQKVHPHGLRVGVIKDWDAKWYADKKNFADNLIEDQQIRKFIKKELFSAGIAKIEIERSAKRVKLNIHTAKPGVIIGKGGSGIERLKASLKNIIAEKNVLINIVEVKNAETNAQLMAENIAAQLEKRISFRRAMKQTIQRAMKAGTLGVKTACSGRLGGAEIARTEQYNEGTIPLQTIRADIDYGFAEADTTYGKIGVKVWVYNGEVLPTKKVEKKEEANA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GCST_THET2
Sequence: MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGEEALAFLQWATANDAGKLKVGRAQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDLAHLQALAKGFRVELEDASERTALLALQGPKAQALLQGLVDVDLSTKRKNDVFPARVAGRPARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELTEETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGCPVGRVTSGGYSPLLQRGIALAYVEEGAEGPFQVEVRGRAVPAALSPLPFVPLK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: GPDA_IDILO
Sequence: MQTPQVTVLGAGSYGTALAICFARKGIPTTLWGRDADKVAVMQTAHENEEYLPACPFPESLKVTADLGEALKDVKNVVVVVPSHSFSSMLKQAKPLLAEHARVAWATKGLEPDSGRLLYEVAEETLGDEHPLAVLSGPTFAIEMAKGLPTAISMSSTDQAFVEELSGLLHCDRSFRVYTNNDFIGVQLGGVVKNVIAIGAGMADGIGFGANARTALITRGLAELTRLGLKLGAKSETFTGMAGLGDLILTCTDNQSRNRRFGMALGQGKGVEEALKSIGQSVEGYRNTREVVALAARNEVEMPICEQIYAVLYEGKEPQQAAIDLLSRERKTE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRE2_HUMAN
Sequence: MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
What is the function of this protein?
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534).  Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534).  Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
What are the official names of this protein?
Sprouty-related, EVH1 domain-containing protein 2, Spred-2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules.
Protein: TGT_STRPC
Sequence: MTDYPIKYRLIKTEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKAIGSGIILSNTYHLWLRPGDELIARSGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAADLVAMDFPGYSIGGLAVGESHEEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSEGRLVIKNAKFAEDFTPLDHDCDCYTCQNYSRAYIRHLLKADETFGIRLTSYHNLYFLVNLMKKVRQAIMDDNLLEFRQDFLERYGYNKSNRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.