PharMolix/UniProtQA huggingface dataset:
Protein: METK_BACC4
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKDDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELMDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_SYNWW
Sequence: MNKVLVLMGGTSEEREVSLKSGKAVYEGLKDAGYEVEALDFTPETIHRIREYSPDVVFITLHGKNGEDGTVQGYLELLGIPYTGSGVLASAVCMNKVITKKLLSYEGLPTADFQVIKKRGFNRDLFNPDLLMEDFGLPLVVKPATQGSSVGTSIVRKRKNIVPALELALSLDEEILVEKFIAGTELTVTVLGKDNLKTLPVIEIVPKNEYYDYESKYMPGMSDHLIPARISEEERERVEEISCKAYDAVGCRGYGRIDLILDRGGNPYILEINTLPGMTGTSLVPDAARAAGIKFPELLDLFVKMALEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNX1_HUMAN
Sequence: MEKSKNFRIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGASGGTSGSCSPASSEPPAAPADRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDHFPYSNGASVHAASSDCSSEDDSPPPRPSHQPAPQ
What is the function of this protein?
Transcription factor (By similarity).  Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity).  Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity).  Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity).  Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity).
What are the official names of this protein?
Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9.
What are the subcellular locations of this protein?
Nucleus.
Protein: FIBB_PAPAN
Sequence: NQEGLFRGR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: CC062_MOUSE
Sequence: MSEKLRRCRKELTAAIDRAFEGVRHSQECTAQQRLDAPSLTSQPVHRLLCRNPLAACPSAAPYSGASCAPESENPAFGTHHIPVNSKLQQPLYPKRKPLTSKENVLMQSSILARDRQFWRAAGDGEDWRKDSLRKDMERDLKADPNVLLSSSSQEVTKDLLDMIDHTSIRTIEELAGKLEFENELNRVCGHCQDSPFKEEAWALLVDESPQKALDADPGSLKQALDDQNIVETVLDLEEDYNLMTSFKYQIE
What is the function of this protein?
Essential for normal spermatogenesis and male fertility.
What are the official names of this protein?
Uncharacterized protein C3orf62 homolog.
Protein: RBSA_VIBVY
Sequence: MNQAILQLSEIEKAFPGVKALDKASLNVYPGRVMALMGENGAGKSTLMKVLTGIYSRDAGEIVYQGQPAQFKGPRDSQQAGISIIHQELNLIRELTIAENIFLGREITSAFGRIDWPQMYAEADKLLARLKVKHSSKTLLGQLSLGEQQMVEIAKALSFESKVIIMDEPTDALTDTETEALFSVIRELREQGCGIVYISHRLKEIFEICDDITVLRDGKFIGQCEVVQTDEDGLIEMMVGRKLEEQYPRIDVVHGQTCLEVIGLTGSGVHDVSFTLKRGEILGISGLMGAGRTELMKVIYGALPSERGVINLDNRTINPVSPQDGLANGIAYISEDRKGDGLVLGLSVKENMSLCALDKLSKGVQIQHQDEVVAVDDFIQLFNIKTPSREQIIGNLSGGNQQKVAIAKGLMTKPKVLILDEPTRGVDVGAKKEIYQLINKFKAEGMSIILVSSEMPEVLGMSDRILVMHEGRITGEFEAKHADQEKLMACAVGKKVSEEAA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: APT_METEP
Sequence: MEARRHSALKDSVRSIPDYPKPGIIFRDITTLLSDPRSFRRAVDSLVHPYAGGRIDQVAGIEARGFILGGAVAHQLSSGFVPIRKKGKLPHKTVSTAYALEYGTDEIEIHVDAIKPGDRVILVDDLIATGGTATAAVNLLRQLGAEVVAACFVIDLPEIGGAQRLRDLGVTVRTLMEFEGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_SHESW
Sequence: MSTGTVVQVIGAVVDVEFPQDAVPQVYDALKITGEGACNGLVLEVQQQLGGGVVRTIAMGSSDGLRRGLEVVNSGSPISVPVGTATLGRIMNVLGEPIDEAGPIGEEERYVIHRAAPSYEDQSNTTELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYYEMKDSGVLDKVAMVYGQMNEPPGNRLRVALSGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDVANGVQTVLQRYKELKDIIAILGMDELSDDDKTTVFRARKIERFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGILNGEFDHLPEQAFYMVGSIDEVIEKANKKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CAMP1_RAT
Sequence: MVDAGGRSAAEGWRRMEAPPEGADLVPLDRYDAARAKIAANLQWICAKAYGLDNIPEDLRDPFYIDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQAATLQGHQSVIQALSRKGIYVMESDDTPVTDADLSQAPIKMSGHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKELPYDLEDAMVFWINKVNLKMREITEKEVKLKQQPLESPAHQKPGLEHAVMHCMLEPVDFARVVRYRREHLSARQSPYFPLLEDLMRDGSDGAALLAVVHYYCPEQMKLDDICLKEVPSMADSLYNIRLLREFSNEHLNKCFYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDIQELKDAKTVLQQKSSRPPVPISNATKRSFLGSPAAMSPADLPPSTQPLTEGSHRYHLHSEEPECLGKGASTFSPSHPLLPLRQKQQKVSQAEEIPDQRHRSNSLTRADGQPRGAAIAWPDKKNRPVSQPTSFALHHAASCDVDPSSGDSISLARSISKDSLASNIIHLTPQNQPHPSAGKTNGKSLLSNVNIEDDEEEELVAIIRTDVSPHSPEIPRTSPQAPGLVASIRSPQRQADTLESKPDSFYLEPLMPAVLRPAKEKQIITKEDERGEGRPRTIMAKRPSEGSQPLVRKKVTGSHGSRDLNRTFTPIPCSEFAASIDPTEVGPQSTEATGEGQPLALGRFDPVPQGQVADGFFLHVGRAEEDEGRWYVGSQSPSSHDSEPWTILRQDSDSDVVDVEDAEQDFIGEDHPVVIPRYAGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTTSQLSSMSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSRHSKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKADGAPQPLRPEHFTKEFTQHNGEDLDDGTCKTEGFLVKEEQRDLSDSQDVAFVQLHKPRDPATLHDGEKHRVISAALLEDSVGEVDVNECDLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPTSGTKNNCQDQKVKAPVHFVEPLSPTGVPGHRKPPRLGQGRNSRSGRPAELKVPKDRQQGCSRSKTPTPSVETLPHSRSLPPSTHPRSPLDPGGELPEKCLFDSYRLHDESNHRTFGLSSCKDANIVSEQMNFKEGLDTSVQEAELSSSAITGKEHTPMEEPLRSKASLIEVDLSDLKAPDEDGEVVGHESSLELGGESDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARARKQQLEAEVELKRDEARRKAEEDRLRKEEEKARRELIKQEYLRRKQQQALEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSQTHSGSSLSLASAATTEPESVHSGGTPSHRVESLEALPILSRNPSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILFRDAGCQFRALYCYQPDTEEIYKLTGTGPKSITKKMIDKLYKYSSDRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPTVPKKTQTRK
What is the function of this protein?
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:24117850).  Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (By similarity).  Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity).  In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (By similarity).  Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850).
What are the official names of this protein?
Calmodulin-regulated spectrin-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the CAMSAP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associates with the minus-end of microtubules. In contrast to CAMSAP2 and CAMSAP3, does not form stretches of decorated microtubule minus-ends.
Protein: GCST_SALEP
Sequence: MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIIYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFTDEQRHAVEGMKPFFGVQVGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPTLGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: G6PI_SYNJB
Sequence: MDSLQLWQRYCDWLYYHPGLEIFVDISRIRFTPPQVEALRPRFAQAFADMQALEAGAIANPDEGRQVGHYWLRAPELAPTPEIRQAIQDSIERVETFAEKIHRGTIPASGGGRFTELLCIGIGGSALGPQFVAEALAPLHPPLNIHFIDNTDPDGFDRVLGRLADQLGQTLVITTSKSGGTPEPRNGLVEVKLAYQKAGIPFSAHAVAITGPGSQLEQQARQEGWLEVFPIFDWVGGRTSETSPVGLLPAALQGIDIRALLAGAATMDEATRLPHLERNPAALLAMAWYIVGQGQGRKDMVVLPYKDRLLLFSRYLQQLVMESLGKSHDLNGNRVEQGIAVYGNKGTTDQHAYVQQLRDGLNNFFVTFIEVLQDREPGIPSPFVEPQVTSGDYLNGLLQGTRQALYENGRDSITVTLPRVDARSVGALIALYERAVGLYASLIQINAYHQPGVEAGKKAASAVLELQRRLLETVQEQQGSLTLPQLAEKLGCPERIETLYWIVRHLHANGRGVLLTGDPARPLELSIQPQPA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_STAA1
Sequence: MNKNKPFIVVIVGPTASGKTELSIELAKRINGEIISGDSMQVYKHMNIGTAKVTPEEMDGIPHHLIDILNPDDTFSAYEFKRLAEDLITDITNRGKVPIIAGGTGLYIQSLIYNYELEDETVTPAQLSIVKQKLSALEHLDNQQLHDYLAQFDAVSAENIHPNNRQRVLRAIEYYLKTKKLLSNRKKVQQFTENYDTLLLGIEMSRKTLYSRINKRVDIMLDHGLFREVQQLVEQGYESCQSMQAIGYKELIPVINGQMIYEDAVNDLKQHSRQYAKRQMTWFKNKMSVHWLDKENMSLQMMLDEITTQIK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TRMB_STRSY
Sequence: MRVRNRKGASELLANNPQYVISNPEECKGKWAEIFGNNNPIHIEVGSGKGRFVTGMAAQNPDINYIGIDIQMTVLSYALDRVLEAGLPNIKLLQVDGSSLTNYFAPAEIDQLYLNFSDPWPKKRHEKRRLTYKSFLDTYKEILPEKGEIHFKTDNRGLFEYSLASFSQYGMVLKQVWLDLHADGLEGNVMTEYEEKFSNKGQVIYRVEAQFQ
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: NAGZ_PASMU
Sequence: MSTLLIDLQGQELSQEEVELLSHPLVAGLILFTRNFHDRAQMQALIQSIRQRVKKPLLITVDQEGGRVQRFREGFTQLPAMQAFACLIDDPVQQTNMAQQAGWQMAAEMTALGIDLSFAPVLDLGHQCQAIGDRSFHSQAEMTLNLASAFIDGMHQVGMAATGKHFPGHGHVIADSHLETPYDERPKQQIFAQDIQPFQQLIQQNMLNAIMPAHVIYSQCDPQPASGSAYWLKQVLRQQLGFNGAIFSDDLGMKGAGFMGNFVQRCEQSLQAGCDLLLLCNEREGVIQVLDNLKLSETEPHFALRQQRLQQLFKRKTIRWSELEATSRWLENRKILTALQQRWLDNKANKH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_THEP1
Sequence: MRAVVQRVSEAKVIVEEKTVGAIKRGLLVFVGVGKDDTEEDCEWLADKVSGLRIFEDEDGKMNLSVKDINGEVLVVSQFTLYGDCRRGKRPSFTEAAPPDKGKALYERFVELLREKGLKVETGKFRAHMHVHLVNDGPVTILLDSSKLF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_SOUV3
Sequence: MMMASKDAPQSADGASGAGQLVPEVNTADPLPMEPVAGPTTAVATAGQVNMIDPWIVNNFVQSPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLSQMYNGWVGNMRVRILLAGNAFSAGKIIVCCVPPGFTSSSLTIAQATLFPHVIADVRTLEPIEMPLEDVRNVLYHTNDNQPTMRLVCMLYTPLRTGGGSGNSDSFVVAGRVLTAPSSDFSFLFLVPPTIEQKTRAFTVPNIPLQTLSNSRFPSLIQGMILSPDASQVVQFQNGRCLIDGQLLGTTPATSGQLFRVRGKINQGARTLNLTEVDGKPFMAFDSPAPVGFPDFGKCDWHMRISKTPNNTGSGDPMRSVSVQTNVQGFVPHLGSIQFDEVFNHPTGDYIGTIEWISQPSTPPGTDINLWEIPDYGSSLSQAANLAPPVFPPGFGEALVYFVSAFPGPNNRSAPNDVPCLLPQEYITHFVSEQAPTMGDAALLHYVDPDTNRNLGEFKLYPGGYLTCVPNGVGAGPQQLPLNGVFLFVSWVSRFYQLKPVGTASTARGRLGVRRI
What is the function of this protein?
Soluble capsid protein may play a role in viral immunoevasion.
What are the official names of this protein?
Capsid protein VP1, CP.
What is the protein family that this protein belongs to?
Belongs to the caliciviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: CBL_MOUSE
Sequence: MAGNVKKSSGAGGGGSGGSGAGGLIGLMKDAFQPHHHHHHLSPHPPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTASKAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSMTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEATQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGATANPVATAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
What is the function of this protein?
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors.  Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome.  Ubiquitinates SPRY2 (By similarity).  Ubiquitinates EGFR (By similarity).  Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.  Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation.  Participates in signal transduction in hematopoietic cells.  Plays an important role in the regulation of osteoblast differentiation and apoptosis.  Essential for osteoclastic bone resorption.  The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.  May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3 (PubMed:10393178, PubMed:12649282, PubMed:19265199, PubMed:20100865, PubMed:9653117).  In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719).
What are the official names of this protein?
E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING-type E3 ubiquitin transferase CBL, Signal transduction protein CBL.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cell projection, cilium. Golgi apparatus. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Protein: WHIA_MYCTU
Sequence: MAMTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDMRGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: NUON_DESPS
Sequence: MMLFLPELALLITALVFFILTLKAPDSPKLHGVALISSVVVIITSLLCLGQTGELFYGAYGISSYSQIFKVFLGIGSLLILLTGKQFCGIKARFRAEYYIFFFLAILGLMMMVSSLDILSILVALELSSFSTYIMVALREDNPRGIHNEAAIKYLLYGVTATAFMLFGMSYLFGLTGSIQLAPLAEKLPQLMNQPIAVTSFILLLAGVFYKLALFPFHFWAPDVYEGAANETTAFAATLPKFGAIAVLIRFATLPGENSQLIINVLLGCALISMFYGNLAALVQKDVKRLLAFSGIAHGGFILLGVLVFENMGYRNAIFYTLAYVLMNIACFFVVSLISEGNKNLQVTDLTGLYKRSPLLAITFITGLFALAGIPPFIGFTGKFMLLAGALKAGHLITVILATFNTALALYYYLNLVRVTFCTDEEKEQAPIQLGVCDRATCILLIASMTLLGIFPTTILTIIESALTTL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: INHBA_HORSE
Sequence: MPLLWLRGFLLASCWIIVKSSPTPGSEGHSAAPNCPSCALATLPKDVPNAQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRSKVTIRLLQQQKHPQGSSDTREEAEEADLMEERSEQLISEKVVDARKSTWHIFPVSSSIQRLLDQGKSSLDIRIACDQCHETGASLVLLGKKKKKEEEGEGKKKDGGEAGAGVDEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINQYRLRGHNPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta A chain, Activin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CDD_PSET1
Sequence: MASATFLVQANTALSNTHISLSVAQTQALRSQLKTQRGILNANNINQLCAQLNVTNDALLQGLVPLASEFAVAPVSNFHVGAIVKALDESGEVNFYFGANAEFNRQALSLVVHAEQSAINNAWLNGAKKILKIAISDAPCGYCRQFMNELADAREFDILLPEQQFKLADLLPHSFGPTDLGNQYSLFNPAPQARSFNNTEVEQQLAAYALAAYVPYSQNYSAVKITTFNNGDFYGSYAENAAYSPSLSPLQSALSQLFLAGLSFDQHTVKGITLLETAGHENQAGVAQAVLASFVNLPPLELISAPLSE
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RL35_VIBVY
Sequence: MPKMKNNKGAAKRFKKTAGGIKYKHATKRHILTKRTTKNKRQLRPNSLLPRCEVAAVARMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.