PharMolix/UniProtQA huggingface dataset:
Protein: NEP_I61A0
Sequence: NTVSSFQDILMRMSKMQLGTSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLYSLPSRNGKWREQLSQKFEEIRWLIEEVRHRAKMTENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs to which the M1 protein is bound.  Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced (By similarity).
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RB33B_HUMAN
Sequence: MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC
What is the function of this protein?
Protein transport.  Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking.  It is involved in autophagy, acting as a modulator of autophagosome formation.
What are the official names of this protein?
Ras-related protein Rab-33B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm.
Protein: GRAS_STAAC
Sequence: MNNLKWVAYFLKSRMNWIFWILFLNFLMLGISLIDYDFPIDSLFYIVSLNLSLTMIFLLLTYFKEVKLYKHFDKDKEIEEIKHKDLAETPFQRHTVDYLYRQISAHKEKVVEQQLQLNMHEQTITEFVHDIKTPVTAMKLLIDQEKNQERKQALLYEWSRINSMLDTQLYITRLESQRKDMYFDYVSLKRMVIDEIQLTRHISQVKGIGFDVDFKVDDYVYTDIKWCRMIIRQILSNALKYSENFNIEIGTELNDQHVSLYIKDYGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVNSVKDQLGIHLQVTSTVGKGTTVRLIFPLQNEIVERMSEVTNLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX.  In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Sensor histidine kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SFSA_ECO7I
Sequence: MEFSPPLQRATLIQRYKRFLADVITPDGRELTLHCPNTGAMTGCATPGDTVWYSTSDNTKRKYPHTWELTQSQSGAFICVNTLWANRLTKEAILNESISELSGYSSLKSEVKYGAEHSRIDFMLQADSRPDCYIEVKSVTLAENEQGYFPDAVTERGQKHLRELMSVAAEGQRAVIFFAVLHSAITRFSPARHIDEKYAQLLSEAQQRGVEILAYKAELSAEGMALKKSLPVTL
What is the function of this protein?
Binds to DNA non-specifically.  Could be a regulatory factor involved in maltose metabolism.
What are the official names of this protein?
Sugar fermentation stimulation protein A.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: DIAA_CROS8
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSGANAQHFAASMINRYETERPGLPAIALNTDNVVLTAITNDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIHEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: STX1A_CAEEL
Sequence: MTKDRLSALKAAQSEDEQDDDMHMDTGNAQYMEEFFEQVEEIRGSVDIIANNVEEVKKKHSAILSNPVNDQKTKEELDELMAVIKRAANKVRGKLKLIENAIDHDEQGAGNADLRIRKTQHSTLSRRFVEVMTDYNKTQTDYRERCKGRIQRQLDIAGKQVGDEDLEEMIESGNPGVFTQGIITDTQQAKQTLADIEARHNDIMKLESSIRELHDMFMDMAMLVESQGEMVDRIEYNVEHAKEFVDRAVADTKKAVQYQSKARRKKICILVTGVILITGLIIFILFYAKVL
What is the function of this protein?
Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:1945043, PubMed:9442061).  Plays a role in synaptic vesicle docking and tethering through its association with unc-18 (PubMed:21423527).  Through binding to unc-18 mediates the release of the neurotransmitter acetylcholine from cholinergic motor neurons, and thereby promotes locomotory behaviors (PubMed:18596236).  Essential for embryonic viability and development.  Has a role in dauer formation and adult life span (PubMed:10377425).  Required for locomotion (PubMed:10377425).  Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142).
What are the official names of this protein?
Syntaxin-1A homolog, Uncoordinated protein 64.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: FMT_MYCUA
Sequence: MRLVFAGTPETALPALHQLIDSPRHDVIAVLTRPDAASGRRGKPEPSPVARAALERGIPVLRPSRPNSAEFVAELSELAPQCCAVVAYGALLGDALLGVPPQGWVNLHFSLLPAWRGAAPVQAAIAAGDAVTGATTFQIEPSLDSGPVYGVVTETIRPTDTAGDLLGRLAVSGAELLSATLDGIAEGALTARPQPADGVTLAPKISVEQARVRWELPVPIIERRIRAVTPNPGAWTLIGDLRVKLGPVYLDAAVEPPGPLPPGAIQVDRKHVWVGTGSEPLRLGQVQPPGKKLMNAADWARGARLDPSVRAS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MIP_CHLPN
Sequence: MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFGHLLARQLRKSEDMFFDIAEVAKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENLSLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGKPSALLHYKGSFINGQVFSSSEGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLIQASADEVAAVPQEGNQGE
What is the function of this protein?
PPIases accelerate the folding of proteins.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase Mip, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: MGN_SALSA
Sequence: MSTSDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
What is the function of this protein?
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
What are the official names of this protein?
Protein mago nashi homolog.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: AT1B1_PONAB
Sequence: MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKIGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
What is the function of this protein?
Involved in cell adhesion and establishing epithelial cell polarity.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-dependent ATPase subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell membrane, sarcolemma. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Protein: MSP4_ANAMA
Sequence: MNYRELFTGGLSAATVCACSLLVSGAVVASPMSHEVASEGGVMGGSFYVGAAYSPAFPSVTSFDMRESSKETSYVRGYDKSIATIDVSVPANFSKSGYTFAFSKNLITSFDGAVGYSLGGARVELEASYRRFATLADGQYAKSGAESLAAITRDANITETNYFVVKIDEITNTSVMLNGCYDVLHTDLPVSPYVCAGIGASFVDISKQVTTKLAYRGKVGISYQFTPEISLVAGGFYHGLFDESYKDIPAHNSVKFSGEAKASVKAHIADYGFNLGARFLFS
What are the official names of this protein?
Major surface antigen 4.
What is the protein family that this protein belongs to?
Belongs to the surface antigen msp4 family.
Protein: YEGP4_CAEEL
Sequence: MCRFPTFLLIAIAITMLPTILSITCFVGKNSVVAEEKDFDYCATMKNISTKEITYSGRTGATRVFEKDANDLTINNCYIDFNDQTALTCYCRRSKCNKVVSSLQFDLMTIATK
What are the official names of this protein?
Uncharacterized protein EGAP4.1.
What are the subcellular locations of this protein?
Secreted.
Protein: PLP3A_ARATH
Sequence: MDPDAVKSTLSNLAFGNVMAAAARNYQKEVLANEKAQGSNPVNEEVDLDELMDDPELERLHADRIAALKREVEKRESFKRQGHGEYREVSEGDFLGEVTRSEKVICHFYHKEFYRCKIMDKHLKTLAPRHVDTKFIKVDAENAPFFVTKLAIKTLPCVVLFSKGVAMDRLVGFQDLGTKDDFTTNKLENVLLKKGMLSKKKKEEDDEDAEYQESIRRSVRSSENLDSDSD
What is the function of this protein?
Tubulin-binding protein involved in microtubule formation.
What are the official names of this protein?
Thioredoxin domain-containing protein PLP3A, Phosducin-like protein 3A.
What is the protein family that this protein belongs to?
Belongs to the phosducin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL14_THERP
Sequence: MIQPLSKLVVADNTGAKEIMCIRVLGGSKHRYGTVGDLIVASVKKAEPNAAVKKGDVVYAVIVRTKKEYRRKDGSYIKFDDNAAVLVTPQGQPRGTRIFGPVARELREKHYMRIISLAPEVW
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: EF2_PYRCJ
Sequence: MSSAVRIVEKQLDEILAIARNPAQIRNAGTLAHVDHGKTTTTDSLLMGAGLLSPKVAGKALAMDYVPIEQLRQMTVKAANISLYFEYGGKPYLINFVDTPGHVDFTGHVTRSLRVMDGGLVVVDAVEGVMTQTETVVRQALEEYVRPVLFINKIDRLIKELRLSPQEIQQRILSIVKDFNALIDMFAPPEFKDKWKIDPGKGQMAMGSALHKWGITIPMAQKAGIKFSNIVDAYEKGYVDKLAEEFPLYKTLLTMIIEHVPPPNVAQKYRIPRLWRGDLNSEVGKALLEADPNGPTVIAVSKVNKDPHAGLIATGRVFSGTIREGDEIYIIGRKMKKKVLQTYIYMGPTRIIVPYMPAGNIVALMGVDEARAGDTLVTPSLADIPPFERMRYISEPVVTVAIEPKNPAELARLVEALKDLVIEDPTLDLKIDQETGQILLSGVGTLHLEIATWLLKERTKVEFSVSPPLIRFRETVRERSQVWEGKSPNKHNRLYFYVEPLDETTVELIATREITEEQDPRERAKILREKAGWDTDEARGVWAIDDRYFNVIVDKTTGIQYLREIRDYIIQGFRWAMEAGPLAQEPIRGVKVVLVDAVVHEDPAHRGPAQIMPATKNAIFAAFLSARPTILEPLVRLDIKVAPDYIGAVTSVINKHRGKILDMTQQEYMAFLRAELPVLESFTISDELRAAAAGKIFWSMQFSRWAPYPESMLADFVKQLRKKKGLKEEIPKPTDFVEAF
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_CLOK5
Sequence: MDKDLRILAIESSCDETSAAVVVNGRIVLSNIISSQIDIHKKFGGVVPEVASRKHIEVISVVVEQALEEAQITFKDIDAIGVTYGPGLVGALLVGLQYAKALSYALNKPLIGVNHIEGHISANFIQYKDLKPPFVCLVVSGGHTYLVYMKDYGKFEVLGQTRDDAAGEAYDKIARAIGLGYPGGPKVDKIAREGNPDAIKFPRANFHDNKTLDFSFSGLKSSVLNYLNQKSMKKEDINKADVAASFQKAVVSFLVDNSLRACKLKNVNKIAVAGGVASNTCLRETFKSQGSKNKVDVLFPEPILCTDNAAMIGSAAYFEYMRGNTSSLNLNAIPNLKLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEP_MELAF
Sequence: GFLSILKKVLPKVMAHMK
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive bacteria (B. subtilis (MIC=0. 8 uM) and S. aureus (MIC=6. 8 uM)), and against Gram-negative bacteria (E. coli (MIC=2. 0 uM) and P. aeruginosa (MIC=18. 5 uM)) (PubMed:18942691).  Stimulates degranulation from rat peritoneal mast cells (EC(50)=19. 4 uM) (PubMed:18942691).  Has very weak hemolytic activity towards rat erythrocytes (PubMed:18942691).  In the context of inflammation and cancer tests, is weakly cytotoxic to normal cells, induces calcium signaling but does not impact cAMP production (PubMed:36548715).  In addition, prevents LPS-induced nitric oxid (NO) synthesis but does not affect the IP3 signaling and pro-inflammatory activation of endothelial cells (PubMed:36548715).  Does not show significant antiproliferative activity on the breast cancer cell line MDA-MB-231 (PubMed:36548715).
What are the official names of this protein?
Melectin, MEP.
What is the protein family that this protein belongs to?
Belongs to the xylopin-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: METAA_DESDA
Sequence: MPIKIPADLPACAALESENIFVMTEDRAVAQDIRPLEIVIVNLMPTKIATETQLLRLLGNSPLQVNITLLRTEAHESKNTPAQHLERFYKTFNEIRHGSFDGMIVTGAPVEHLPFEDVDYWHELLDIMNYAASHVYSTLYICWAAQAALYHFYGIPKFSLPQKISGIFNHDILLPDCRLFRGFDDTFTAPHSRNTEVRAGHILETPQLRLLAQSEQAGVTLVERVDHSQVFMTGHLEYDRGTLDAEYRRDVDRGLKPRVPEHYYPHDDPAAMPRMNWRAHAHLFYCNWLNYYVYQETPFSLTAIAQNREARAGA
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HST4_EMENI
Sequence: MAPRKTKPATKPAAKPTPASTATTSSCPSPKSFPIPMEVDDFSFSDSELSDAQSLIEPEGFSLLSPDESSGGRSQDELPPARKKRRVAGPKERRTQHLDLTPRLGFSDYGDQEPQLNLLVNTIRNHKKIVVIAGAGISTSAGIPDFRSDDGLFKTLQKKHNLKASGKLMFDAAVYQDEALTASFQEMVRSLSEEAEKSSPTAFHHMLARLGSDNRLTRLYTQNIDGIETSMPPLATQIPLNVKAPWPRTIQLHGSLEKMVCQKCRHMSTFDRVMFDRPDAPECPECVLTNQFRMETGQRSHGIGKMRPRIVLYNEHNPDEEAITSVMNADIRSRPDALIVVGTSLKIPGVRRLVKSLCSVIRSRRNGVTMWINNEPPSGKEFEDCFDLLVKGDCEEVARLAQLKRWDDDSKPIFDECQSADVERVKNEQGPLSVVITTPKKEKVQAQTGMLTPSSSYDGDVENASTTTLSNPASKGRKLTEILKASKKDAPKTESAGVKKPAPRKRTKKEPVKNAKITTFSKVTKAQKVTPEEKSVKLEEHKAMHPLPPGAARTNAPMLPGLAKDDSKSTPSGKRGQLETISPDRIPKGMGKLLD
What is the function of this protein?
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
What are the official names of this protein?
NAD-dependent protein deacetylase hst4, Homologous to SIR2 protein 4, Regulatory protein SIR2 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP6_MYCPN
Sequence: MSPRAIVLKEPNGVNLVPHEGIFDISPVAGWKPLLPTDQVFGIFVVFIVLLTLFLVYWIKLRKADPLRNHSSFVLLMQMLFVWAQDTTADLIGEENKKFTPYFLMLLLYLVSSNLIGLLGGISPPTSSLTFTFSLGLATFLGIVIMGIRYQRWSFFKSFTFNITIKGKKYSTLIPNPLSFLGEFAPLFSISLRLWGNILGGTLILALFYNFWFFAFSTLSNKPLALSLGAIFAGILTPALHVYFDVVVGTLQGYVFVMLTYNYWAKMRNIGLEESQEAAQRLQNLEVAKEIIN
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA_CLAMS
Sequence: MASVLEKVLRVGEGRTLRKLQNYAKAVNQLEEDFTHLTDEELKNETVELRERHANGESLDDLLPEAFAAVREASRRTLGLRHFDVQIMGGAALHLGNIAEMKTGEGKTLVATLPAYLNAIASRGVHVITVNDYLASYQSELMGRVFRALGMTTGVILAGQTPQQRREQYAADITYGTNNEFGFDYLRDNMAWQASDMVQRGHFFAVVDEVDSILIDEARTPLIISGPSAGDANRWFTEFANVAKRLVPEVDYEVDEKKRTVGVLETGIEKVEDHLGIDNLYESANTPLISFLNNSIKAKALFKKDKDYVVMNGEVLIVDEHTGRILMGRRYNEGIHQAIEAKEGVAVKAENQTLATVTLQNYFRLYKKLSGMTGTAETEAAEFMSTYKLGVVPIPTNRPMQRKDQSDLIYKNEKAKFEQVVEDIAERHAAGQPVLVGTTSVEKSEYLSKLLAKKGVRHEVLNAKNHAREAAIVAQAGHLGSVTVATNMAGRGTDIMLGGNAEFLAVAAMNARGLSPVETPEQYETEWDDVFAQVKAEVDEEAAKVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRLFNNGAAASLMGRDSVPDDVAIESKVVSRAIRSAQGQVEARNAEIRKNVLKYDDVLNRQREAIYGDRRHILEGDDLQERSQRFLEAVIDDVLDSHIGEGNGDDWDFDALWTELKTLYPISITIDEVITEAGSKGRVNRDFVRREILSDAKLAYSKREEQLGEAAMRELERRVVLSVIDRRWREHLYEMDYLKDGIGLRAMAQRDPLVEYQREGFALFQQMMGAIREETVGFLFNLEVEVQAPADAESVGPRIQAKGLAANQATADKLRYTAPTDDGGVEVRNQRGQIEKAATAKAQKDQQAEDAVLVGEDEPETPQGPPARGAFGQPTGASSAPQNREERRKADRRK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: HLDE_CAMJ8
Sequence: MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDKSGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISAILLENELIALFDEKIKDFKAVVLSDYAKGVLTPKVCKAVIKKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFALRYSIITLSEAGIALFDEGLKIAPAKALEVYDVTGAGDSVIAVLAFCLASGIEIFKACELANEAAAVVVSKIGSMSVSFDEIKSFNRVDFEKKIKSKEELLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILIKGADYKDKLVVGADIVSKVELIDFEEGFSTSKIIEKIKDKK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: UBE12_ARATH
Sequence: MEPFVVKENIIASASSPMKKRRIDHTESADGSAINASNSSSIGLNNSIGGNDTVMSMAEFGNDNSNNQEIDEDLHSRQLAVYGRETMRKLFASNVLISGMQGLGVEIAKNIILAGVKSVTLHDENVVELWDLSSNFVFTEEDIGKNRALASVHKLQELNNAVAVSTLTGKLTKEQLSDFQVVVFVDISFEKATEIDDYCHSHQPPIAFIKADVRGLFGSLFCDFGPHFTVLDVDGEEPHSGIIASVSNENPGFVSCVDDERLEFEDGNLVVFSEVEGMTELNDGKPRKIKNVKPFSFTLEEDTSSYGQYMKGGIVTQVKQPKVLNFKPLREALKDPGDFLLSDFSKFDRPPLLHLAFQALDRFSSQAGRFPFAGSEEDAQKLVEIAVDINEGLGDARLEDVNSKLLRHLAFGSRAVLNPMAAMFGGIVGQEVVKACSGKFHPIFQFFYFDSVESLPKEPLDASEFRPQNSRYDAQISVFGSTLQKKLEDARVFVVGAGALGCEFLKNLALMGVSCGTQGKLTVTDDDVIEKSNLSRQFLFRDWNIGQAKSTVAATAAAGINSRLNIDALQNRVGPETENVFDDSFWENLTVVVNALDNVTARLYVDSRCVYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSDPVEYMKAMRTAGDAQARDTLGRVVECLEKEKCNSFQDCITWARLRFEDYFANRVKQLCYTFPEDAATSTGAPFWSAPKRFPRPLQFSSTDLSHINFVMAASILRAETFGIPTPEWAKTRAGLAEAVERVIVPDFEPKKDATIVTDEKATTLSTASVDDAAVIDELNAKLVRCRMSLQPEFRMKAIQFEKDDDTNYHMDMIAGLANMRARNYSVPEVDKLKAKFIAGRIIPAIATSTAMATGFVCLEMYKVLDGSHKVEDYRNTFANLALPLFSMAEPVPPKVVKHQDQSWTVWDRWVMRGNPTLRELLDWLKEKGLNAYSISCGSSLLYNSMFSRHKERMNRRVVDLARDVAGVELPAYRRHVDVVVACEDDNDADVDIPLVSVYFA
What is the function of this protein?
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
What are the official names of this protein?
Ubiquitin-activating enzyme E1 2, AtUBA2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
Protein: RK22_HORVU
Sequence: MTSFKLVKYIPRIKKKKSGLRKLARKVPTDRLLKFERVFKAQKRIPMSVFKAQRVLDEIRWRYYEETVMILNLMPYRASYPILKLVYSAAANATHYRDFDKANLFITKAEVSRSTIMKKFRPRARGRSFPIKKSMCHITIVLNIVKKSK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RECF_SHEB5
Sequence: MSLTRLNIEAFRNIQSAQLIPAPGINLIYGQNGSGKTSILEAIYFLGMGRSFRSHLSQRVINNDDDKLTLFATLNLARGDSKIGLRRFRSGETEVRIDGEKVKRLSTLAETLPIQVITPESFSLLFEGPKSRRQFIDWGAFHADPQFYGAWTNVRRVLKQRNQLLRNGSAYSNIQFWDQEFVRYAEQVTEIRNHYVDSLNELLKGIIGEFLPSVDVKVSFTRGWDSKTDFAELLENQYSRDLATGHTVSGPHKADLRLRVGTLPAQDALSRGQLKLLVCALRIAQGKLLKQQIDKHSIYLVDDLPSELDAQHRQLLLKQLTDTGAQVFVTAIDPAAIVDSLHTPPSRMFHVEQGRVTVIE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.