PharMolix/UniProtQA huggingface dataset:
Protein: TX1A_PELMU
Sequence: MKTFVFIVLVALAFVLTAAKEERANPSELVSALAELVMLDAERGVDKPGCRYLFGGCKSDDDCCPRLGCKGKGHDYCAWDGTFSD
What is the function of this protein?
Multimodal toxin that enhances nociceptor excitability mainly by the simultaneous stimulation of repetitive firing (through Nav1. 8/SCN10A channel current enhancement) and impairment of repolarization (by inhibiting delayed rectifier current of Kv2. 1/KCNB1), with a potential contribution from tetrodotoxin-sensitive voltage-gated sodium channels (Nav) modified excitability.  Enhances Nav1. 8/SCN10A currents (EC(50)=1. 1 uM), modifies the channel gating by a right-shift in steady-state inactivation and delays open-state inactivation.  Also decreases Kv2. 1/KCNB1 currents (IC(50)=0. 43 uM) and causes a depolarizing shift in the voltage dependence of activation without change in steady-state inactivation.  In addition, inhibits peak currents of human sodium channels (Nav1. 1 to Nav1. 7, IC(50)=0. 38-2. 3 uM) and delays fast inactivation of Nav1. 1/SCN1A, Nav1. 3/SCN3A, Nav1. 6/SCN8A, and Nav1. 7/SCN9A.  In small dorsal root ganglion neurons, induces hyperexcitability by enhancing tetrodotoxin-resistant sodium currents, impairing repolarization and lowering the threshold of action potential firing, consistent with the severe pain associated with envenomation.  In vivo, elicits nocifensive behavior in mice after intraplantar injection.
What are the official names of this protein?
Delta/kappa-theraphotoxin-Pm1a, Delta/kappa-TRTX-Pm1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MYG_INDPC
Sequence: MGLSEAEWQLVLHVWAKVEADLSGHGQEILIRLFKGHPETLEKFDKFKHLKSEAEMKASEDLKKHGHTVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISDAIIHVLHSKHPSDFGADAQAAMTKALELFRKDIAAKYKELGFHG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CRCB1_CUTAK
Sequence: MAMRSGFLDRRPVLVGLVFLGGCLGTLIRSVIAHAWPSRADGVPWGTLAINLVGAFVLATLLELLVHAGPDRGVRRAVRLCIGTGLLGGFTTYSALTVEAGQRVMSGQWLWGIAYLLTSVAAGALLAWVVIAAVRCVMGKRSS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OXR1_CANGA
Sequence: MFNVKGALNRLRTTWSNSEESDRDPRHLKSSDDLSNYTGSRMSYEETLPPVTLLGYSPKTKNRLLHPEMCDELRPLMPTRIQLYTEWTLLYSLEQHGASLHSLYDKLREDASTPRRVGYVLVIKDRKDGIFGAYSNEPFHPHEHMRYSGNGECFLWKMESVPNKILRAKIREDKDEDLIDVNDDEDKINNSGTVNESWKLCAYPYTGANDFMIYCTSKFLSLGAGEGHYGLWCDDGLMKGVTNPTQTYGNDVLSREGRKFTIMGLEVWRVG
What is the function of this protein?
May be involved in protection from oxidative damage.
What are the official names of this protein?
Oxidation resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FB322_ARATH
Sequence: MANSSSFSPSTTVTDLISTVHDDIIESHILTRLDGATLASVSCASSHLHHLASNEILWSKICRSTWPSCSGGSRSFFSDAYSMVETAGTVSDLDRPFPELISAVDLHYRGKLIFSRVVKTETTTAWFKSSPLRIDLVDTKDTVATPIKRRQRTEDTCRDLEKDLTLSWIVIDPIGKRAANISSHRPVSVQRNWISGEVEAQFATVVGAVECVITVVTCGEEEMHVREVSLKVEKMEGTHLNGRDSLVILRSVMEGKRVNGSRREVESKKRHEEFMEKKREMKEKKMRVESVFDILTVAFGILGFVLLVVFCLWRTSI
What are the official names of this protein?
Probable F-box protein At2g36090.
Protein: GLGA_PSELT
Sequence: MRVAMVAYEVYPFAKVGGLADVVGSLPKVIEKQGVKVTVFMPFHKIVSKNCEKLGLEIKEVARAISLPNLQTKEKFDLYKSTVPATNVSVYFISNDYYFSADNVYEGPDLAEQSIFFSNAAIEAMKYLSETFDIVHAHDWQTGLVPVYLKTLYRTDPFFNRTATVFTIHNLGYQGVFNPGYMKFAGLPAYLFNIDGLEFYGQINFLKGGILFSDIVTTVSPTYAQEIQTEQFGEKLDGVLRLRAEDLYGILNGIDYSEYNPATDKRIYVNYDIDHIEKKKMNKSELQKELNLQVRDDVPLIGMINRLVDQKGLDLIEKIVDYMMMFDIQFVVLGTGDKKYEEFFKNIEKKYPQKISSNMKFDVDLAQKIYAASDMFLMPSRYEPCGLGQMYSLRYGTVPIVRYTGGLADSVKEYDPKTRDGNGFGFREYDTAHLLETVAKAVYFYKKEKDHWGKVVKNAMKTDVSWDRSAKQYLKIYQEALRKKQF
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: Y036_MYCTU
Sequence: MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQIGHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVTRGRLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRLRSIAHLGVRTRDYAFIVNNLTPPAEPFLVELRGPSGDTWSWGPSDAAQRVTGSAEDFCFLVTQRRALSTLDVNAVGEDAQRWLTIAQAFAGPPGRGR
What are the official names of this protein?
Uncharacterized protein Rv0036c.
Protein: TX18A_MANRB
Sequence: MKNNYNRINTFIVYLMVTFSLISIISITECTPNHDPCPPQYAEALCLNGGTCFSVTIMGSDNYNCICAPGFRGWRCQEKDLDHPVNQ
What are the official names of this protein?
U18-myrmicitoxin-Mri1a, U18-MYRTX-Mri1a.
What is the protein family that this protein belongs to?
Belongs to the EGF domain peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y382_TREPA
Sequence: MGAAGKEGAQCQGGDVCELVRHRLTMQADVLESGGVCGRI
What are the official names of this protein?
Uncharacterized protein TP_0382.
Protein: Y507_HELPJ
Sequence: MGIIYLILFLIVIYLLYRILDVLEQK
What are the official names of this protein?
Uncharacterized protein jhp_0507.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YCIB_VITS1
Sequence: MNAKTLDAIKPFLDWIPLIVFFYIYKTTEGEGSEHIIAATTGLLIATLIVYGLMFVLQKFTLEKRQWLVVVLTVVFGGLTMAFQDDFYIRLKAPIINAVFAFGLAMSPLFLGGTPGIQKMLGPIFEMTPKQWMKLNWVWVGFFTLMAVLQALFAFVWVEYWAMFTAFGDMIVMVVFMVAQFWFLRGFMRKDIK
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS5_SACS2
Sequence: MKALVINYGVGNLYSISSALKRVGFEVTIDNKPRNDYDLIVFPGVGAFSAVAEFILRYRELFNDLRRSGTNFLGVCLGMQIMFEKGTEGKESNGLGWFKGIVDKINANVKLPHIGWDLVFEVKDSCELTYGLDKKYVYYVHSYVAYPTSGDYVYMKSQYGIEYPALVCDKNVVGTQFHPEKSSNTGKIFLENLKGWIKR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CARHZ
Sequence: MVMTDPIADFLTRIRNANMVYHEKVEVPSSKVKRAIAEILKEEGFIKDYEYIEDGKQGILRIFLKYGPNKERVISGLKRISKPGLRVYAKKDELPRVLGGLGIAIISTPKGIMTDKKARKEGLGGEVICYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ATPA_METPB
Sequence: MDIRAAEISAILKEQIKNFGQEAEVTEVGQVLAVGDGIARVYGLDNVQAGEMVEFESGVRGMALNLEQDNVGVVIFGSDREIKEGQTVKRTGAIVDVPVGKGLLGRVVDGLGNPIDGKGPIQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVGRGQRELIIGDRQTGKTAIALDTILNQKPAHSGTDENAKLYCVYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDAAPMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMGDAAGKGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQGVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVNKVREFEDQLLGTLRSKHQDWLDSVRDSKDLSDANANTLKGVVESIAKSFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL27_SALTY
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGEAVLAGSIIVRQRGTKFHAGTNVGCGRDHTLFAKADGKVKFEVKGPKNRKYISIVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: KC1A_CHICK
Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKSKSNMKGF
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  It can phosphorylate a large number of proteins.  Participates in Wnt signaling.  May play a role in segregating chromosomes during mitosis.  May play a role in keratin cytoskeleton disassembly.
What are the official names of this protein?
Casein kinase I isoform alpha, CKI-alpha, CK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle.
Protein: SYTC_AERPE
Sequence: MASGQDKTHIDYAYELDITVKPDSRVPVFNREFATFTGAGVPLFSLGGGPIRYALAEVLAKFHARRGYYVVETPIIASTELFKVSGHIEFYRNNMYLFDIEGHEFAVKPMNCPYHILLFLNEVAKHRSKLPLPFKVFEFGRVHRYEPSGSIYGLLRVRGFTQDDAHIIVPGGRVIDVVYDVFEEMKLVLERLFKLGVSSETFKVRLSMSDKSLIGKEFMGSKEEWEGAEEALREAASRINEKYGIDIVELEGEAAFYGPKLDFIMMVEESGVSKEWQMGTIQFDFNLPRRFRLYDVVREEFGIEEVYIIHRALLGSIERFLGVYLEHRRGRMPFTLAPIQFAVIAVKTGGEVDREIEDLASSIAKGLLDKGFRVAVKGSSKTGLSSDVRHIESTAKPAVNVFIGAKEVREKVLDVRVFDLESMKRRRLAIAYGDAADAVENLAAVAEELESPVRSLSGQAPRIPADFSFML
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (Probable).  This protein is probably not able to deacylate mischarged L-seryl-tRNA(Thr) as it lacks the appropriate domain (PubMed:19761773).
What are the official names of this protein?
Threonine--tRNA ligase catalytic subunit, Threonyl-tRNA synthetase 1, ThrRS 1, Threonyl-tRNA synthetase catalytic subunit, ThrRS-cat.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A28_MYXVU
Sequence: MNPVTVFFVVVVTVAVCMILFQVYSIYLNYDNIKEFNAMHSPLEYSKMVNVTAIDRRVQDANDDIYDAKQKWRCVKFDDSYVSLSMFGYKADGVGIRRFRTLNGCIDYTFSTSTHSSILNPCIPPNDPKSRECTFLKSAL
What is the function of this protein?
Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).
What are the official names of this protein?
Envelope protein A28 homolog, MA28.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A28 protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Note=Component of the intracellular mature virion (IMV) membrane.
Protein: TIG_MALP2
Sequence: MKITSVKNEKELVSFEIDLSEKKWNEFLDKEILKASKNLKMPGYRPGKVPLEIAKKNINMPVCFVNALSSARERIEDWIIDQDEFKKMADEICDFDPVTSKPNNSNNVLNKTVSFTMSFGKYPEFKVKNVKDIKIEKIESKVNKQMVDQAIEKELAKNETMSVKERAAKLNDIVIIDFKGYVDNVAFEGGEAKNYELKLGSKSFIDNFEEQLVGLKAGDKKDVNVTFPKDYHVANLKGKKAKFEVTVHVVNEVETPKLDDEFVKSLNLKNVNTVAEYKKHLEAELQKQLDGTVDNQIQSALYTELNKMVPSDLKIHEGLVNNVAEIFISRLMISLIGKVVNIDEFVKMIDGGRGALTKEKLIEEEKNQAREYLKVKFALKQYSKVEKISVSNEDIEKEIKEIAANSNTKEKEIKEDFAVYSSIKREALDKKVFEYLKNQVAKAAK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: QUEF_ALISL
Sequence: MTKYTNADELKSLTLGQKTEYKHSYEPELLQAVPRSLNRDDLALGDELPFVGCDVWTLYELSWLNQNGLPQVAIGDVVLPATSPNLVESKSFKLYLNSFNQTKFSSWEDVTSTLIKDLSVCAGEEVMVNIHPVQAYSQQPIVDMQGECIDNQDIVIDSYEFDANYLESSTSEKMVNEVLHSHLLKSNCLITNQPDWGSVEINYEGNKIDHEKLLRYLISFRQHNEFHEQCVERIYTDIMKFCSPKSLTVFARYTRRGGLDINPFRSSHLIKPEHNLRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRTN_DANRE
Sequence: MMEDEDFLLALRLQEQFDQETPAAGWPDEDCPSSKRRRVDPSGGLDVIPFTQPRAERPLSIVDESWETLDPNPDVRAMFLQFNDKFFWGKLSGVEVKWSPRMTLCAGVCSYEGRGGLCSIRLSEPLLKLRPRKDLVQTLLHEMIHALLFVTQNNRDRDGHGPEFCKHMNRINQASGTNITIYHSFHDEVDVYRQHWWRCNGPCQNRRPFFGYVKRAMNRPPSARDPWWADHQRSCGGTYTKIKEPENYGKTGKSDKQRDKMPATEMPKKSKPPSSTSSSGSQDIRNIIPFSGRGFVLGGNAQIPTNKQIQSPPKAPPEPLHSPPDSPLLPRLQLNEDNLKRLSSGTSNIPRKRSVGNTNAFINVNGSPVRISNGNGSGGKQRSVRDLFQAIVLKSPDRGASAVGSSKSSTDASTADYRSNSALDAKPSGKTSLITDHLSYTISGPKTLSAESNISKYFGGSAKTDVQDSKLKTFGSPQKSAIGTPGYVSKAFGSNQRPDSTSSGIRNTGSPQRSHASATSGSSFKHFRGPAKPESNFPSPRNIGSPRTSGTTPSGAKKRSWEEHNSERVFDYFQRTVGESATSTDKKREEVRSEAPPPVRDQQANNPPAQITVHCPVCHIRLPESTINDHLDSCLL
What is the function of this protein?
DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (By similarity).  DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde.  Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis.  Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity).  Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs.  SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity).  May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis.  Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity).
What are the official names of this protein?
DNA-dependent metalloprotease SPRTN, Protein with SprT-like domain at the N terminus, Spartan.
What is the protein family that this protein belongs to?
Belongs to the Spartan family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress.
Protein: RL35_SULNB
Sequence: MPKMKSVKGAVKRFKVKKSGKIKRGTAYRSHILTKVDGKHHRQMRSSKHVDTVDAKNIKEMIN
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: NDK_PHEZH
Sequence: MTERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFGELVEFMTSAPVVVQVLEGENAVARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDSLENAKIEIAQFFTEDEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SYMTH
Sequence: MRYLTAGESHGRALVTIVEGLPAGVPVDLAAIDRDLARRQSGYGRGGRMKIEQDRVQVLSGIRHGKTLGSPVALLVENRDWLNWTEVMSPAPLEAYTDPRAAQKVRTRPRPGHADLAGALKYDHADLRNVLERASARETAARVAAGSLAKQYLAPFGIRVAGYVRSIGPVEAQPPAGLDLDGIVARAEASPVRCPDPAASARMVEEIDAAKRDGDSLGGVVEVVAAGLPPGLGSHVHWDRKLDGALGAALLSIQAAKGVEIGDGFLGARRRGSEVHDEIGWSPDRGYFRYTNRAGGLEGGMTNGMDLVVRVAFKPIATLYKPLRSVEIDTHVEAAAGIERSDVCAVPAAAVIAECVTAFELARFVAEKFGGDSLEEALRNFRGYLEQIARR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: GXCH_DICDI
Sequence: MENINIEYGIDSNLNLDKFQDNEMEIKNLSKSFDNNNNNNSNTNNIKNNNRERSRRKSLSMPLLEPLPKPKRPPVPPRAFLMNDGADEKITNYIPTTPPSINITFEKKEDGDNYDDNYDDNYSGEDIKTSTTPPQFNSPEFNKNKPLPPIPIDQEKEDYHTMAPKPLPRVPSKIETFNDQNNNEGLQNSTSPLSSSPPPLGNLLNTSNGWRSANKPIDSSFSNIAPKRSTTLFDVTNPTIFPSSLNSSGSCCSSSGSGGKSPSNFLNFEPSKPNFENFDDYVFGNDSSELSQSQISPVVRTRRQRVFTRKAATMKLLDNGVDTDDENESELSKKSGTTLDSEPNLKSVSSSNRGSFVISKSSYNLRGSCSDEDDQENQTTNKNNSNNNNNNTTTNNNNNNNNNNNNNKDTLKVTETKHGRTVSLPEEPVSTLIPNATVSKKRPSLFNKFDFKSVIFEKIEEQQQKFESIPSRRSQLPYINDSTIFNKVVKEIIETEADYLDHMEITINFYLFAALEMVKYKILEKRDIFSIFSNFEEVYHISLKIYPMLLNCIPLLEKNQYPNIEEVFLFNSKSFQRYGSYLSSHDSCNKFLQEILLTNQTAAQIFQKLIPICKLNNLHSFLIKPCQRLCKYPLLLKELSKALPKEDEQNHKTIKRTTSLMGKIVSDINGKMKNDTKIQEIIKEIGTKDIEYLLHHQTFIGEGKVKKVNKNGSTSEGTLYLFNQRIVFAEKNSLFNKKATVISLSNISRVCDYDYRYPSGFAIYHNSKKVSTSSSSNLGTLSLGALIIISDEKLKWMNKIEDQIVSERVLAGTYTYVTNHFESFKNLENCSFSQSDSQSDFVDHDIQQEQQEQQQQQQEEEQTRVKIPQIVEPLSQQHDQPKLDHQQSSIQPKLSFPHLKQPKQDEKPIKKPKSPKHKNTEPENFSFY
What is the function of this protein?
GTPase-activating protein.
What are the official names of this protein?
RhoGEF domain-containing protein gxcH.
Protein: SYV_CAMJR
Sequence: MYDKNLEKEYYQICEERGYFEIDGNKTIQEKDKNFCIMMPPPNVTGVLHIGHALTFTLQDIMTRYKRMDGYKVLYQPGLDHAGIATQNVVEKQLLAQGIKKEELGREEFIEKVWEWKEQSGGKILDQMRTLGITPAWSRLRFTMDEGLVNAVKKAFVELYDKRLIVRGNYMINWCTHDGALSDIEVEYKENKGKLYHIKYFLKDSDEFLVVATTRPETFFGDTAVMVHPDDERYAKFVDKEVILPISKKAIKIIADEHVEKEFGTGVVKVTPAHDMNDYEVGLRHNLDFISVFDEKGILNEHCLEFQGLERLEAREKIVAKLESLGFIEKIEEYNNQIGYCYRCNNIVEPYISKQWFVKKEIAQESIEKVALGESKFYPNHWINSFNAWMKDLRDWCISRQLWWGHQIPVYYCECSHEWASQHTPKTCPKCQSQNFKQDEDVLDTWFSSGLWAMSTLGWGNENWGKDKIWSEKDLKDFYPNSLLITGFDILFFWVARMMFQSTNVLHQLPFKDIYLHALVKDEQGRKMSKSLGNVIDPNESIKEYSADILRFTLALLAIQGRDIKLSNDKLLQVRNFTNKIYNAKNYLLLNESKFEDLENITLHSELAKYIYAKFQTCVKDVRENLDNYRFNDAANTLYKFFWDDFCDWGIELSKAEKSSVKELGSIFKEALKLLNPFMPFISEYLYHKLSDTELKTSPSIMISKYPKFKEQDKNIEKIFSLLIESIVSIRRAKSLIDLGNSKIEKAYIKFNDKKIKDEIKAYMNFIIMLAKCEQIEFSEEKLPKAICDVSENLEIFITLENVDLSGILTRLENQKNKLEKESFKLNSMLSNEKFIANAPKEVVEQNKEALENLKIQLEKISVELQNLRG
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX20_HUMAN
Sequence: MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN
What is the function of this protein?
Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284).  Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053).
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX20, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX20 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISPF_SYNAS
Sequence: MRVGCGYDSHRWAAKRKLILGGVEIPHEFGLTGHSDADALTHAICDALLGAISEGDIGFQFPDSDPAYSGISSLKLLSKILEMVDKKGFAIDYIDSTVIMERPKLMPYIPDMKSKIAGVLKMPSDRINIKAKTNEGMGFVGRQEGVAVFAVALVKENQD
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: F118B_MACFA
Sequence: MASTGSQASDIDEIFGFFSDGAPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSGMVREGQLNGSSAAHSEIRGCST
What is the function of this protein?
May play a role in Cajal bodies formation.
What are the official names of this protein?
Protein FAM118B.
What is the protein family that this protein belongs to?
Belongs to the FAM118 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body.