PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_MYCBP
Sequence: MNDSNDTSVAGGAAGADSRVLSADSALTERQRTILDVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVNVRGADDAALPPVTEVAGSDALPEPTFAPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGTLFLLKVIGDSMVEAAICDGDWVVVRQQNVADNGDIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PAN_PYRHO
Sequence: MSVMSGDEVQFQGDYDDYITYLKRRIRQLELQVRMLEADKERLERELSRLRSEMSRLRQPPAFAGTVIEVLDEDRAIVQNYNGPRFVVRIAPWIDRKKLRPGTRVALDQRTMAVVEILPTSKDPTVLGFEVIERPNVTYNDIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKALAHEVNATFIRVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRMDETTGGEREVNRTLMQLLAEMDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDFEGRLEILKVHTRRMKLKGVDLRAIAEMTEGASGADLKAIATEAGMFAIRERRTYVTQEDFLKAVDKVLGNERKLLQQITSHEVIYG
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIS1_DROSI
Sequence: MKMVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: NDHH_LIRTU
Sequence: MTVPDIRKDFMIVNMGPHHPSMHGVLRLIVTLDGEDVIDCEPVLGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFRERELLYDLFEAATGMRMMHNYFRIGGVAADLPHGWIDKCLDFCDYSLTGVVEYQKLITRNPIFLERVEGVGIIGGEEAINWGLSGPMLRASGIQWDLRKIDHYECYDEFDWEVQWQKEGDSLARYLVRISEMAESIKIIQQVLEGIPGGPYENLEVRRFDKARDSEWNDFEYRFISKKPSPTFELSKQELYVRVEAPKGELGIFLIGDNSVFPWRWKIRPPGFINLQILPQLVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: Y804_THEVB
Sequence: MYTIDLILRHVPMPVSIERKESAAAMAVYQQIQQAMASGTPTFLELTCDRQVGKKLTVLTSEIVAVQMADKDAPSSTISRGGFFAQLVQQTSN
What are the official names of this protein?
UPF0367 protein tsr0804.
What is the protein family that this protein belongs to?
Belongs to the UPF0367 family.
Protein: RLMN_ALKEH
Sequence: MNLLDLDRQALKRLFADLGEKPFRATQVLKWVHQRRVTGFEEMTDISKALRARLAERVALRLPEVLAEQVSEDGTRKWLLRVDGGQAIETVFIPDSGRGTLCVSSQVGCALDCSFCSTAQQGFNRNLSTAEIIGQYYVAYDQLTGTGEQITNVVFMGMGEPLLNLEAVIPAVRLMTDDDAYGLSKRKVTISTSGVVTMLERMREQTDVSLAVSLHAPNNALRDELVPINRKHPLERLIPACAAYIADKPHRRITWEYVMLDGVNDQDHHAHELARLLGDIPSKVNLIPFNPFPGARYRCSPRGRILRFVRILQSHGLTATTRVTRGQDIDGACGQLVGKVQDRTRRQQRLVQRELRREGR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR7_TETOB
Sequence: MPRRPIQKKRSVLPDPIYNSISVHMLVNRVMKNGKKSLAYKIVYNTLKNIGETTQQNPVEVFEAALENVMPKVEVQPRRRAGSVQMVPSILRSTERGQATALRWILESCEKKSAKSMVSKLQTEILDAYEKKGNAIKKKEELHKIAANNAMYSNRPQIILNAVSIVS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL32_PROM2
Sequence: MAVPKKKKSKSKRNQRHAVWKGKAAIAAQKAISLGKSILTGKAQGFVYPIEEEEEE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LEXA_MYCS2
Sequence: MSDDTGEFTDGSTESPADADGAGRRRAVDNGLTERQRTILEVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRAADDPAAAAVVTTDVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGDSMVDAAICDGDWVVVRQQNVADNGDIVAAMIDGEATVKTFKRARGQVWLMPHNPAYDPIPGNEAAVLGKVVTVIRKI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RNH3_STAHJ
Sequence: MANIVYKLSESEIQHLLQQITFETSQLSPGMKARTKYKQSVINIYNSGKVMFQGKNAEAVAQQLLPDHTTTSKNSSSSNQSSGETLAYNHYNCIGSDEAGSGDYFGPLTVCAAYVSKENVKILKTLGVDDSKKLNDQKIIELAEQLITFIPHSLLTLDNPKYNDRQAIGWSQVKMKAELHNEAIKNVTQKINCNELNYIVIDQFAVRGVYQRYALSSLPYPEKTKFETKGESKSLAIAAASIISRYAFVKHMDHISHKMKQDIPKGASNKVDLIAAQIIDKHGIETLDLISKKHFKNREKAQNLVTKKYK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRLR_DICDI
Sequence: MVIKKPFIFIFICFLICLLICIDLTNCNTINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNENHKILKDYLKFTKRFKKSEYPTTEQQDFYINKIKKEIKDREKYKNNIENEILKINSQKKRKKFKRKDLNTDIKTNHEQLRKLIENNVNPNPHYYDETQSFYFTNRMTSNNEKNNKKNLNFNNDNNKINNLINIKNNNIPYINNNNNNNNNNNNNNNNNNKNNNNNNNNKNNNNNNNNKNNNNNNNNKNNNKNKKIIINNNNLINNKLVSETSANMTTMVNSGDASLRSLINFLTTQDNNGLRFFPYSPRDLINPFNATKAISVAFAYNDRQLITPGAFSKENEEIRANQSRSQGLFDPNSPNMNFSSFYDIIDQQQTNFVQNIELSIDYLLNQVYFKEIFSKKDFKTQARDFEALFEFLKQQGTRVVYYYIANDGSNHVECGGSIKPCQDLAYLLQSVPMADRIQTDLVVFFYPGRYNITKRIVIDNFSKVQLVGLFGKDETTLTSNQKMFLFNNTHIHMIGLTIADVNFQMKPLLNIFKTDNLGTGTVFDLRQSIMTILLCDFRNISNRNSLGSVFAYNSNLTVSNTLFENTIAAVGGGIFCCSYSTCIVSNCTFRANIADNPIGGGALIASLSTLFITQSAFYNNKASIGGSVIIDGGFSTVDTSTFEYNTGFVGSAIQISPNSIVYIVNCYFYFNLATYSGASIFCGSSTVVFISKCIFKDNYSPGANGLESYSEKLVLIEESVFEGNIPPLLNSTSVVSIASPSAFLFVRQCSFFGHSGVIFNIGNPSVLYCSFSLFYENSNRIVNSFNNGLIVFGSCKLFNNSNNKSDGIFRINNRSNGIFYAVEFYNNTVSSFFESWFNSTCFLLSSNITNNTFRAGSFQVAFSTDIFVDNLLYSNNTAAEGGLISSDQTGGISVTNSLLIGNTAEFGNLVFFRLLSYSEPNCDSFIFENNTYVDNYAFMAGTIVYFDDTIRCNYSCINCVSVNNNAQYGEIVNTGFATFSSTLPNTIPPSIIRPIILQAFDALGLPYLGRSDITFNLLINLLICDQMSLTGVVQSTSTPTSFSVFYNVRISGAPGTHCNLTVIAFLKTFKNITLEYPITVVNCQEGQDPYNIGGVNSYYCLTDVSKTKIAKIIIGISAIIVSIGVLITAILTFIYRKRKIMRYSNPVFLLIILVGCVCGLVSTFVSFSTTSATCSIRMVLIPLFFFIITSAIFIKQYRVYCLIRGVEELHDMSIENSYLLKLQSFILIIPAILIAVSVIATRMHRKYNFDLQKETIQAYCYSKNFYIIFICLALYEFSILLYGCWIVIKCRQYRSFPGSFNEFFYIGVLIYVLTVILVVSIPIGFALLNSALTDFLLYSIPILVLIVAIIGLLFAPKFYFLFRTDKVIANLRQLIEDQEEILKKNKEVLFTYGMYLGDNNNDIIALHESFSDSDILSKTGSNTSDDVSDDFTFDSPTTYSNIPIPLNRRNNNNNNINNNNNNNNNNNNNNNNNNNNNNNNNILNNNKNNNNDDDASSSNSSSTADFEISSSGESGRSSNDYDKRNNKKNRRKNSLRTPILNSLLSPNSRNKTKKRNKSSQNSPLLD
What are the official names of this protein?
Metabotropic glutamate receptor-like protein R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KTHY_ALKEH
Sequence: MTRGRFITLEGLEGAGKSTALTRVREYLQRQGIDAVMTREPGGTPLGERIRALLLGQSEPPMAPATEALLMFAARSEHLDKRIWPALERGQWVVCDRFTDASYAYQGWGRGLGAERIAALEDWTQGALRPDLTLWLDVPVETGLARAAGRGEAPDRFEQERDGFFERVHEGYAALAERFPERIRRVDAGQPLEAVLTALEEALASAVTRWLSGTEAH
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LDH_STREM
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYADCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVALARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFSKEEFASAAKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RATA_SHIFL
Sequence: MILFVGFLLMEIVMPQISRTALVPYSAEQMYQLVNDVQSYPQFLPGCTGSRILESTPGQMTAAVDVSKAGISKTFTTRNQLTSNQSILMNLVDGPFKKLIGGWKFTPLSQEACRIEFHLDFEFTNKLIELAFGRVFKELAANMVQAFTVRAKEVYSAR
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes.  Its antitoxin is unknown (By similarity).
What are the official names of this protein?
Ribosome association toxin RatA.
What is the protein family that this protein belongs to?
Belongs to the ribosome association toxin RatA family.
Protein: METK_STREM
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETCVYTGSVHVFGEISTTAYVDINRVVRDTIAEIGYTEAEYGFSAESVGVHPSLVEQSPDIAQGVNEALEAREGQSDDFNVIGAGDQGLMFGFAIDETPELMPLPISLSHQLVRRLATLRKSGEISYLRPDAKSQVTVEYDEHDKPVRVDTVVISTQHDPEVSNDQIRQDMIEQVIKAVIPAHYLDEKTRFLINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSASYAARYIAKNLVAAGLASKAEVQLAYAIGVAQPVSVRVDTFGTSTVSESILEAAVRQVFDLRPAGIIKMLDLKRPIYKQTAAYGHMGRTDIDLPWEHLDKVSPLTEAVAALSEGA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_MYCS2
Sequence: MTNGVPALDDILERLHVVALPMRVRFRGITVRELALIDGPAGWGEFGAFVEYEPPEAAAWLSSALEAAYRPAPAALRDRVPINATVPAVSAERVPEVLARFPGARTAKVKVAEPGQSLADDVARVNAVRESVPVVRVDANGGWSVDDAVEAAAALTADGELEYLEQPCATVEELAALRARVDVPIAADESIRKAEDPLRVVRAHAADIAVLKVAPLGGVARMLDIAAQIDIPIVVSSALDSSVGIGRGLLAAAALPELRHACGLGTGGLFVDDVAEPRVPVDGCLAVEPAVPDPARLAALAAPEPRRQWWIDRVCACHALI
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: CBID_PROM1
Sequence: MNQFTLPVWVVAAAKSATNILIGNKFRDKERIDLPNKEESISVPISSSALLDNGKRSLAVSHCQSGLPLDITRGVEIWAYIQLSKGSSQSKGKVQNGFPDWLDFHAGCGVGKFQSSGQPCISQFARDLLCINLYPLVPKGNSIKVEIILPEGKDRASKTSNEAFGVVDGLSLIGTQAEVQISASPDQLKNCKEILYHKCSEAKFDGCLTFVIGENGMDLAMKYGLPANQIIKTGNWLGPLLVAAAENGVKKLLLFGYHGKLIKLSGGVFHTHHHLADGRIEILTSLAFREGISFDLIELISKSTSVENALLTLEVSNPDAVSLIWSRMAKEIEIKSRSYVNRYLSSSMEIGSVLFDRKRQMRWAGLEGLKQINSLGLILKR
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: APOM_HUMAN
Sequence: MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSNN
What is the function of this protein?
Probably involved in lipid transport.  Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
What are the official names of this protein?
Apolipoprotein M, Apo-M, ApoM, Protein G3a.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
Protein: AK2_BACSU
Sequence: MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGIRTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVALAAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEFAKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHPSAV
What is the function of this protein?
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
What are the official names of this protein?
Aspartokinase 2, Aspartate kinase 2, Aspartokinase II.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: TRPA_SALPK
Sequence: MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGANALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPEQMLAELRSFVSAMKAASRA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TDA11_YEASZ
Sequence: MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNMRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVQKLS
What are the official names of this protein?
Topoisomerase I damage affected protein 11.
What is the protein family that this protein belongs to?
Belongs to the TDA11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_COCIM
Sequence: MSASPDYKTNLLSHLISNKVLSFGSYTLKSGRNSPYFFTTTLLHTAPLLHATASACASVLSSPPFVTTSTPDGTPRPNFDIIFGPAYKGIPLCTAVLNELGVRDTTGAWNNISYSFNRKEAKAHGEGGNIVGAPLKGKKIVIIDDVITAGTALREAVGIIEKEGGTVVGVLVLLDREERVNDNEKKSAVGCAQRDLGENVPVKAVLSLSDIIEKLGNDIGEENLKRLKEYRAQYGAEE
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RL27_CHLPB
Sequence: MAHKKGGGSTKNGRDSNPKYLGIKASGGSSVSAGSIIVRQRGTVFKPGNNAGIGKDHTIFALVDGNVHFRNTRNDKKLIDILPS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SFSA_SYNY3
Sequence: MDFLYPYPPLISGILVKRYKRFLADVELDNGEIVTAHCPNTGPMTGVCQVGAQVYLSKSDNPQRKLAYTWEMIQIDGTWVGVNTALPNRVIKQALADRIFPNLTNSYDTFKPEVPYGKDKKSRIDFLLTKPEEKSIYVEVKNTTLSQEKLALFPDTETTRGQKHLQELIDILPTARAVMLYFINRGDCTHFSPGDAYDRRYGELFRQAIAAGVEVMPCRFMVNPEGVKFLGMAELVV
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: UMPS_MOUSE
Sequence: MEVASQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTAKNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHAVCTLSQMLEILQQQEKIDADMVGRVKRFIQENVFSAANHNGLPPPEKKACKELSFGARAELPGTHPLASKLLRLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTALAKRHEFLIFEDRKFADIGNTVKKQYESGTFKIASWADIVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGNYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVIGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSRLAVQ
What is the function of this protein?
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
What are the official names of this protein?
Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the OMP decarboxylase family.
Protein: DNAA_ECOLI
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Also required for replication of plasmid DNA; binds 4 dnaA boxes in the minimal plasmid RK2 replication origin (oriV).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFR1_CHICK
Sequence: MEEAACGKLTSLCHTPKDSGTAAPQRTSSGKQPMSATLRERLRKTRRSFTTNFAVAKRLKVDTEEKDCTDVDNRCLPKIGMDCSTLQDGSECLEQNCTVNTYFKSPLQENNLCESAENVVRVDLGQQQSLGEKVRLMKQVKEKEELLRRLKLVKMYRSKNNLSELQALIVKWRSSTQLMLYELQAAFSADGKKVSLSQLIDTFGLEDHLLHYSRAEEDFVDT
What is the function of this protein?
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (By similarity).  May act as a transcriptional modulator for ESR1 (By similarity).
What are the official names of this protein?
Swi5-dependent recombination DNA repair protein 1 homolog, Meiosis protein 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the SFR1/MEI5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: R3GEF_BOVIN
Sequence: MWSGQPHPDEGHPPPLEAVPVPWKSVGPCKSHRESLGGLPETPAGEEAQGEEGPAATQLDVSRLRSSSMEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHLRHKSTSSALCPAVCPVAGHILTPDKEGKEVDTTLFAEFQAWRESPTLDKTSPFLERVYREDVGPCLDFTMQELSALVRAAVEDNTLTIEPVASQTLPAVKVAAVDCGHTNGFRAPIDTTCALSGLACACRHRIRLGDSESHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEITRLRKEMSLAKLGFFPHEA
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.  May also activate RAB8A and RAB8B (By similarity).
What are the official names of this protein?
Guanine nucleotide exchange factor for Rab-3A, Rab-3A-interacting-like protein 1, Rab3A-interacting-like protein 1, Rabin3-like 1.
What is the protein family that this protein belongs to?
Belongs to the SEC2 family.
Protein: RBFA_NATTJ
Sequence: MSGMRKEKLQEELKKIISDILQREVKDPSVGFVTVTSVDLSGDLRHAKVFVSILGEKENQQDSLRGLEKATGFIRSELGKRVRLRHVPEIVFKFDESIEHGDHINKLLKQMNLGEDNEDNEDKENNDPGEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_CAUVC
Sequence: MSQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSDALAAESADLLYHWLALMAASGVSLDAVAEKLEAREGTSGIAEKASRA
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.