PharMolix/UniProtQA huggingface dataset:
Protein: PLS1_PITAZ
Sequence: LKKSLFLVVFLGLATLSICEEEKRETEEEEYNQGEDDKSEEKRFLSLIPHAINAVSTLVHHFG
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Phylloseptin-Az1, PLS-Az1, Phylloseptin-2, PS-2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OXLA_BOTMT
Sequence: IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:22438972).  Is moderately active on L-Leu, L-His, and L-Phe, and very weakly active on L-Thr, and L-Cys (PubMed:22438972).  Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation.  Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation.  These different effects are probably due to different experimental conditions (By similarity).  Inhibits growth of B. subtilis strain ATCC 6633 (MIC=32 uM), E. faecalis strain ATCC 12953 (MIC=32 uM), S. aureus strain ATCC 29213 (MIC=32 uM), S. pyogenes strain ATCC 19615 (MIC=8 uM), E. coli strain ATCC 8739 (MIC=4 uM), K. pneumoniae strain ATCC 13885 (MIC=2 uM), P. mirabilis strain ATCC 25933 (MIC=2 uM), P. aeruginosa strain ATCC 15442 (MIC=8 uM) and S. typhimurium strain ATCC 14028 (MIC=8 uM) (PubMed:22438972).
What are the official names of this protein?
L-amino-acid oxidase, Bm-LAO, LAAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNLJ_ECO55
Sequence: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKNNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLEQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDEAEMLRLLGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ACPS_RICTY
Sequence: MLIGVGTDIVQIPRIEKILNLYQELFAKKILTSQELKQFTLLDKPNHATFLAKRFAAKEAVSKAFGVGIGQGINFKNITIINDNLGKPVVEVSSHYTNKLIPFHIHLSLSDDYPICIAFAIVESNCSV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y329_AGARV
Sequence: MARRGGFPGGMPGNMNNLMKQAQKMQRQMEEAQKQLEDAEVTAKAGGGAVEVTVSGKKEITKVKLSEEVVDPDDIEMLEDLIMAATNEALRQIDEQSQASMSKITGGLGGGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein EUBREC_0329.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YNI3_FRAAL
Sequence: MSEAKDFLRDLLDQVRAGDSYGQLDRFSDSQLLAPFVVTKEQRRTIATNCDLDIATAARLRSFYQAVAAATEKATGAFTTTILDLNSEGFGRVIIFAGRLVVLDNALRDVQRFGFNSSEELAARGEALVLGASKLIERWSEVARDDS
What are the official names of this protein?
UPF0460 protein in nifX-nifW intergenic region, ORF3.
What is the protein family that this protein belongs to?
Belongs to the UPF0460 family.
Protein: ATOH7_DANRE
Sequence: MKPRRPSCADSGSDSDSRDPEKFESAMRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALNRILSDAGRHVDPQKDWLNLQFDGLQTEGYFMHYDSPVESDCMLSSFSYHYESL
What is the function of this protein?
Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity).  Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development (PubMed:10985346, PubMed:11430806).  Required for retinal circadian rhythm photoentrainment (By similarity).
What are the official names of this protein?
Transcription factor atoh7, Atonal bHLH transcription factor 7, Helix-loop-helix protein zATH-5, zATH5, Protein atonal homolog 5, Protein atonal homolog 7, Protein lakritz.
What are the subcellular locations of this protein?
Nucleus. Perikaryon. Cell projection, axon.
Protein: RL29_THEP3
Sequence: MKAREIRELTNEELLQKLSDLKAELFNLRFQLATGQLDNPMRIRDVRKTIARIKTILRERELGIRQNKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: TCEA3_MOUSE
Sequence: MGLEEELLRIAKKLEKMVSRKKTEGALDLLKKLNSCQMSIQLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPRTTKGEREEREKAKKEKGLGCSDWKPEAGLSPPRKKGGGEPKTRRDSVDSRSSTTSSPKRPSLERSNSSKSKVETPTTPSSPSTPTFAPAVCLLAPCYLTGDSVRDKCVEMLSAALKAEDNFKDYGVNCDKLASEIEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISPELIAKMTAEEMASDELRELRNAMTQEAIREHQMAKTGGTTTDLLRCSKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC
What is the function of this protein?
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
What are the official names of this protein?
Transcription elongation factor A protein 3, Transcription elongation factor S-II protein 3, Transcription elongation factor TFIIS.h.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DINI1_BPVT1
Sequence: MRVEICIAKEKITKMPNGAVDALKEELTRRISKRYDDVEVIVKATSNDGLSVTRTADKDSAKTFVQETLKDTWESADEWFVR
What are the official names of this protein?
DinI-like protein.
What is the protein family that this protein belongs to?
Belongs to the DinI family.
Protein: MGRB_ENT38
Sequence: MKKIRWVILIIVLIACVILWTQTINVMCDQDVQFFSGICAINQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CLPP_BRUA1
Sequence: MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLEAENPKKEINMYINSPGGVVTSGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHRYALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNEIYVKHTGRDYDTIERTLDRDHFMTAQEALEFGLIDKVVEARDVSADESK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5HT1D_RABIT
Sequence: MSPSNQSAEGLPQEAANRSLNATGTPEAWDPGTLQALKISLAVVLSIITVATVLSNTFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQVLCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAVVWAISICISIPPLFWRQAKAHEEVSDCLVNTSQISYTIYSTCGAFYIPSVLLIVLYGRIYMAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLSPSLGEGHSHSAGSPLFFNPVRIKLADSVLERKRISAARERKATKTLGIILGAFIGCWLPFFVASLVLPICRDSCWMPPGLFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQRVIHFRKAF
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity.  May also play a role in regulating the release of other neurotransmitters.  May play a role in vasoconstriction (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1D, 5-HT-1D, 5-HT1D, 5-HT-1D-alpha, Serotonin receptor 1D.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBLL_CHLTE
Sequence: MNAEDVKGFFASRESLDMEQYLVLDYYLESVGDIETALAHFCSEQSTAQWKRVGVDEDFRLVHAAKVIDYEVIEELEQLSYPVKHSETGKIHACRVTIAHPHCNFGPKIPNLLTAVCGEGTYFTPGVPVVKLMDIHFPDTYLADFEGPKFGIEGLRDILNAHGRPIFFGVVKPNIGLSPGEFAEIAYQSWLGGLDIAKDDEMLADVTWSSIEERAAHLGKARRKAEAETGEPKIYLANITDEVDSLMEKHDVAVRNGANALLINALPVGLSAVRMLSNYTQVPLIGHFPFIASFSRMEKYGIHSKVMTKLQRLAGLDAVIMPGFGDRMMTPEEEVLENVIECTKPMGRIKPCLPVPGGSDSALTLQTVYEKVGNVDFGFVPGRGVFGHPMGPKAGAKSIRQAWEAIEQGISIETWAETHPELQAMVDQSLLKKQD
What is the function of this protein?
May be involved in sulfur metabolism and oxidative stress response.  Does not show RuBisCO activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase-like protein, RuBisCO-like protein.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type IV subfamily.
Protein: EFP_XANC5
Sequence: MATVGMNDVKNGMKILVNNEPAVITETEYVKPGKGQAFTRMKYRFIKSGRVVEMTMKATDDVEVADVVDTDMRYLYSDGEYWHFMDPETFEQVQTDKAGMGGADKWLKGEEDCIVTLWNGTPIWVQPPNFVELKITETDPGVRGDTSGGGGKPATLETGAVVRVPLFVNQDEIIKVDTRSGEYSARVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MARE2_MOUSE
Sequence: MPGPTQTLSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKRASSSGSASRSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMEVLYASDEQEGQTEEPEAEEQAHDQQPQQQEEY
What is the function of this protein?
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.  May play a role in cell migration (By similarity).
What are the official names of this protein?
Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2.
What is the protein family that this protein belongs to?
Belongs to the MAPRE family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules (By similarity).
Protein: HSLU_CAMJJ
Sequence: MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGVGKTEIARRLAKMMGFPFIKIEASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKDKIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTKLRNGNLDESTIEIEISQNMFDTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALKRAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILFIAAGAFHLSKPSDLIPELQGRFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENLELEFDDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLEDLSFEADEYAGKKFVVDKKMVEEKLGDIIENKDLARYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF5A2_MEDSA
Sequence: MSDEEHHFEPAADAGASKTYPQQAGTIRKNGYIVIKSRPCKVVEVSTSKTGKHGHAKCHFVAIDIFNGKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGFVSLLTDNGSTKDDLKLPTDDSLLTQIKDGFADGKDLVVSVMSAMGEEQICALKDIGPK
What is the function of this protein?
The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-2, eIF-5A-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
Protein: ITIH4_MOUSE
Sequence: MKSPAPAHMWNLVLFLPSLLAVLPTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRADAVQEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQKQYSAAVGRGESAGIVKTTGRQTEKFEVSVNVAPGSKITFELIYQELLQRRLGMYELLLKVRPQQLVKHLQMDIYIFEPQGISILETESTFMTPELANALTTSQNKTKAHIRFKPTLSQQQKSQSEQDTVLNGDFIVRYDVNRSDSGGSIQIEEGYFVHHFAPENLPTMSKNVIFVIDKSGSMSGKKIQQTREALVKILKDLSPQDQFNLIEFSGEANQWKQSLVQATEENLNKAVNYASRIRAHGGTNINNAVLLAVELLDRSNQAELLPSKSVSLIILLTDGDPTVGETNPTIIQNNVREAINGQYSLFCLGFGFDVNYPFLEKMALDNGGLARRIYEDSDSALQLQDFYHEVANPLLSSVAFEYPSDAVEEVTRYKFQHHFKGSEMVVAGKLQDQGPDVLLAKVSGQMHMQNITFQTEASVAQQEKEFKSPKYIFHNFMERLWALLTIQQQLEQRISASGAELEALEAQVLNLSLKYNFVTPLTHMVVTKPEGQEQFQVAEKPVEVGDGMQRLPLAAQAHPFRPPVRGSKLMTVLKGSRSQIPRLGDAVRASRQYIPPGFPGPPGPPGFPAPPGPPGFPAPPGPPLASGSDFSLQPSYERMLSLPSVAAQYPADPHLVVTEKSKESTIPEESPNPDHPQVPTITLPLPGSSVDQLCVDILHSEKPMKLFVDPSQGLEVTGKYENTGFSWLEVTIQKPHLQVHATPERLVVTRGRKNTEYKWKKTLFSVLPGLKMTMNMMGLLQLSGPDKVTIGLLSLDDPQRGLMLLLNDTQHFSNNVKGELGQFYRDIVWEPPVEPDNTKRTVKVQGVDYLATRELKLSYQEGFPGAEISCWTVEI
What is the function of this protein?
Type II acute-phase protein (APP) involved in inflammatory responses to trauma.  May also play a role in liver development or regeneration.
What are the official names of this protein?
Inter alpha-trypsin inhibitor, heavy chain 4, ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4.
What is the protein family that this protein belongs to?
Belongs to the ITIH family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAS2A_PYRAE
Sequence: MIWLAVYDIEDDGERAKASAILQAWGFVRVQRSFYVGRMPRGKAADLLKILQRHVKSGHIALIPITDELLAKALELGRPPYAPLKPPKYAQIYVV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: IDI2_BACMK
Sequence: MVRAKRKLDHIEYALSTGQSRTHGFHDIDFVHQSLPNSSYDTITCETKIGELSLSSPIFINAMTGGGGEQTLHINEQLAYVAKHHNLAMAVGSQMAALKDESESASYKVVRKVNPNGIFFANLGSEATVEQAERAVDMIEANALQIHLNVIQELTMPEGDRDFTGVLQRIEKIVLKSKVPVIVKEVGFGMSKETVQQLANIGITAIDIGGQGGTNFAAVENERRQRMLSYFNNWGIQTATSIIEATSTNNNLSFIASGGIQTALDVAKAIALGANTTAFAGYFLRILMQDGVENLVDEIDLLHTDLKFIMTALGVKTIEELQSVPLVVKGETYHWLAQRGIDTAHYSRR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX3_MOUSE
Sequence: MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRHVPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
What is the function of this protein?
Phosphoinositide-binding protein required for multivesicular body formation.  Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)).  Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (PubMed:19576982).  Plays a role in protein transport between cellular compartments.  Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC).  May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (By similarity).  Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (PubMed:18632802).  Not involved in EGFR degradation.  Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (By similarity).  Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (PubMed:23416069).  Involved in regulation of neurite outgrowth in primary neurons (PubMed:19576982).
What are the official names of this protein?
Sorting nexin-3, SDP3 protein.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome. Cytoplasmic vesicle, phagosome. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures. Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (By similarity).
Protein: TRPF_RHIE6
Sequence: MKPDIKICGLKTPEAIDRALKRGATHIGFIFFEKSPRYIEPDLAAKLAEPARGKAKIVAVVVDPTNDELDEIVSLLKPDILQLHGNESPEHVLTIKALYGLPVMKVFSVRTAADLKRVEAYIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSIDYMLSGGLNKDNVANALANTTARGIDVSSGVESAPGVKSVAMIDEFFDAVEGADAPVMASGS
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MIC19_EMENI
Sequence: MGAGSSKPEASAGSKHIFESNSPIQFSSNLVDGLQSNTETDSARAKSLELEIQNRVAKELERLRAREQQTLAEIEKRLSEAKDTGSFASAPSAPAVTHYPAGSLDLDAPRIPFAGREYAPPPPAAVEVAAVNKELNRESVNSEIEELRVKLEGRKKLAELDEGVAKAQKDVVSCLRLNDRRPLDCWKEVAEFKKEVARLEEGFVDRIVG
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity).  Involved in osmoadaptation.
What are the official names of this protein?
MICOS complex subunit mic19.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic19 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: ATPD_ARTS2
Sequence: MAGVSSESLTAALVALEAKLPFASLQLAKELFGILGTVDSSAGLRRALTDPSRSGDEKSALVKQLFGGKVSTDAAEIASGLAGSRWASARDIGDALETLAASVVIAVAENKSAVSASGITGLEALENDLFAFNHAVDSSHEVQRALSEPQASPAAKIALAEKLVPNASEEAKVLIGQAVSHPRGLKATNLVRRFAELAAKRQQRWIATVSVTRPLTESQTGRLQAGLNALYGRELKINMNVDPALIGGIRIQVGDEVVDASLLTRLGQLQRQLAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS3_ROSS1
Sequence: MGRKVHPIGFRLGYIKDWQSKWFAERNYTELLHEDVMLRKIIAKELENAGVARIEIERSANKVEVTVYTAKPGIVIGKRGAKVDELRAELEKRTGKKVKLNIQEIHQPELEAQLVAESIAEQINKRVSYKRAMKQAVQRAMRLGAQGVKIKCSGRLAGAEMARVAWERDGRVPLHTLRADIDYAQVHAHTTYGRIGVKVWIYKGEVFPDQKGQTQLPQPAVAAARPGLTVEEEERPQRKGGRGGRGANAGAARGGRGGRSRS
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RS10_PSEPK
Sequence: MQNQQIRIRLKAFDHRLIDQSTQEIVETAKRTGAQVRGPIPLPTRKERFTVLVSPHVNKDARDQYEIRTHKRVLDIVQPTDKTVDALMKLDLAAGVEVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ECFA1_BACAH
Sequence: MKKEKLRTENISFQYPGAATYALKDVSFSLFEGEWVSVIGQNGSGKSTLAKLLNGLFLPEAGTITVNDTMILSEETVWDVRKQIGMVFQNPDNQFVGTTVQDDVVFGLENIGMPREQMVERLNQALRLVRMEDFLNDEPHSLSGGQKQRVAIAGVLALQPSILILDEATSMLDPQGRREVVETVRQLVNEKGITVLSITHDLEEAAQSDRVIILNKGEILEEGTPEQIFKSSHMLQEIGLDVPFSVKIAELLKRNEILLQNTHLTMESLVNELWRLHSKK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS10_BORA1
Sequence: MKNQKIRIRLKAFDYKLIDQSAAEIVDTAKRTGAVVRGPVPLPTRIRRYDVLRSPHVNKTSRDQFEIRTHQRLMDIVDPTDKTVDALMRLDLPAGVDVEIALQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.