PharMolix/UniProtQA huggingface dataset:
Protein: PRDX1_HUMAN
Sequence: MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.  Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357).  Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
What are the official names of this protein?
Peroxiredoxin-1, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Thioredoxin-dependent peroxiredoxin 1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: FOLD_CAMC5
Sequence: MKILDGKATSAKVKAEVKERASALKNAGIEPALAVILVGSDKASQTYVAAKQKACEASGIRSVMHKLPQTTSQNELLALINVLNLDDSIDGILVQLPLPAHIDTTSVLETIWPQKDVDGFHAENVGKLVSGLDGFVPCTPLGIMRILKEYGIDVAGLNAVVIGRSNIVGKPMASLLLNASATVTITHSKTRNLKQICSAADLIVAAIGKPNFVTADMVKEGAIVIDVGINRLDDGRLVGDVDFEAVAPKSSFITPVPGGVGPMTIAMLLSNTIRSAQNRAKNLGIVKE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PVK1_POPSU
Sequence: QGLIPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FB253_ARATH
Sequence: MSSCSRTRTKAPRSARSRRNGGFSSSSATIVADIDDVLIQILSFLPIKTLLRFKRVSKRWLSLITNPVFSNRVIKSNHPLPISGFFLHSPREIKYSFVSLDDDATNQRISSSLPLWFTDHQTDMIIMQSTNGLLLCKCSCASSNHFNTNYYVYNPTTKQYTLLHQIAGHIALSLAFDPSRSPHYKVFCLRGRSNNSFSSASDSELYHIEVYSSNEGLWRRVVPVPTSPSTFIEFSYSVFWNGAVNWYGFSSRDCLSFDINTQEIKILPLPDHEHEDEPLPDPRILMFLDESQGNLYYIEVNNQSSSNLRVYEMESNSSSWSVKYNVDLEPLAAAFPEMIRTEYYTDRRIYAFSVIGFVKEETDAASYILLHIPNQAVKYNFIDKTFKKLCDFKSLVNDAPEDHFYRFQRTFQFIKSLANV
What are the official names of this protein?
F-box protein At5g07610.
Protein: CBIT_METM7
Sequence: MIQDSEFFRMEGVPITKEEIRAVSIGKLNLNPEDIVLDIGCGSGGMSVEISKRSKFVYAIDNSEDAKNTTVTNLKKFKIENCEVFLGDAKDLISEFDFNKVFIGGTQNIEQILEILKEKKIEKVVANTIVLENSVKIISKFEELRYNVDFVNVSVSYGKKINSGHIMLSKNPITIITATLK
What is the function of this protein?
Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
What are the official names of this protein?
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating).
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
Protein: YFGM_AGGAC
Sequence: MAYTIEEEQELTAIKAWWNENYKFIIVCFVIAFGGVFGWNYWQSHQIQKMHKASAEYEQALFNYQKDPKAQAEQFNQFIKNNEKTSYAVLALLDKAKIAVENKDFPLAEDALKQAMAQSNDDILSSVSALRLASVQFQLGQLDPALESLKSVKEQAWNSAKNLLAGDIQLAKGDKETAKKSYQQAQENAGALEQQLIQVRLNNL
What is the function of this protein?
May mediate protein transfer from the SecYEG translocon to the periplasmic chaperone network via its periplasmic C-terminal region.
What are the official names of this protein?
Ancillary SecYEG translocon subunit, Periplasmic chaperone YfgM.
What is the protein family that this protein belongs to?
Belongs to the YfgM family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SYI_ECO8A
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFAVSNVNGPISLVIWTTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAELELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPDGTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKDTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGSTHSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTARFLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPGEREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAVTLYAEPELSAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEKCPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_ROSDO
Sequence: MSHEVPNAIDVRNAVKRYGDFTALKTISLSIRDNEFFTLLGPSGCGKTTLLRMIAGFEDVTEGEIFLYGEEIEDLPPNRRPVNTVFQNYALFPHMDVMENVGFGLEMLGKPKAQARARAGEILELVQLSQFANRKPSQLSGGQQQRVALARALAPQPKVLLLDEPLSALDLKLRKAMQLELKHLQRETGITFIFVTHDQDEALTMSDRIAVMSAGELQQLGDARDIYEKPANRFVADFIGETNLFEVTIKSRDGTRVLCAFLNGLTLTCDAVAGMDVGDRVHMSIRPERIKLRSSKVETENFQAQVVENIYAGTDVQTIVHLQGGMPLAVRTQNSEIGRSMTFEPGAEVFVDVEFGSARLLAN
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: 5054R_ASFB7
Sequence: MFSLQDICRKYLFQLPDSFDEYTLQVLGLYWEKHGSLQRIRKDAVFVQRNLIISINEALRIAASEGNGRVVKLLLSWEGNFHYVIIGALEGDHYDLIHKYGSQIEDYHMILSSIHNANTFEKCHELSNCDMWCLIQNAIKYNMLPILQKHRNILTHEGENQELFEMACEEQKYDIVLWIGQTLMLNEPEFIFDIAFERIDFSLLTMGYSLLFNNKMSSIDIHDEEDLISLLTEHLEKAATKGCFFFMLETLKHGGNVNMAVLSKAVEYNHRKILDYFIRQKCLSRKDIEKLLLVAISNSASKKTLNLLLSYLNHSVKNIIGKIVQSVLKNGDFTIIIFLKKKKINLVEPALIGFINYYYSYCFLEQFIHEFDIRPEKMIKMAARKGKLNMIIEFLNEKYVHKDDLGAIFKFLKNLVCTMKHKKGKETLIVLIHKIYQVIQLETKEKFKLLRFYVMHDATIQFISMYKDCFNLAGFKPFLLECLDIAIKKNYPDMIRNIETLLKCE
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 505-4R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
Protein: PANC_MYCTO
Sequence: MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALHEGHLALVRAAKRVPGSVVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEIAFTPTTAAMYPDGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQLVADFNLDVAVVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALTAAAHAATAGAQAALDAARAVLDAAPGVAVDYLELRDIGLGPMPLNGSGRLLVAARLGTTRLLDNIAIEIGTFAGTDRPDGYRAILESHWRN
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MK06_RAT
Sequence: MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSPSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKDKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDAFIAGTVQLSAQRESADVVDKLNDLNSSVSQLEMKSLISKSVSREKQEKGRANLAQLGALYQPSWESQFVSGGEECFLISQFCCEVRKDEHVEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSSGGEFLLSRQLESIGTPQFHSPGGSPLKSIQATLTPSAMKSSPQIPHKTYSNILKHLN
What is the function of this protein?
Atypical MAPK protein.  Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5.  The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6.  May promote entry in the cell cycle (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6, Extracellular signal-regulated kinase 3, ERK-3, p55-MAPK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Protein: ERG12_YEAST
Sequence: MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS
What is the function of this protein?
Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:1645230).  ERG12 converts mevalonate into 5-phosphomevalonate (PubMed:1645230).  The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.  Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate.  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8.  The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate.  The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
What are the official names of this protein?
Mevalonate kinase, MK, MvK, Ergosterol biosynthesis protein 12, Regulation of autonomous replication protein 1.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GLNA3_RHIME
Sequence: MTLDLSTFAREKGVKYFMISYTDLFGGQRAKLVPAEAIADMQKGGAGFAGFATWFDLTPAHPDLFALPDASAVIQLPWKKDVAWVAADCIMDDAPVEQAPRVVLKKLVAEAAQEGLRVKTGVEPEFFLISPDGSKISDTFDTAEKPCYDQQAIMRRYDVIAEICDYMLELGWKPYQNDHEDANGQFEMNWEYDDALRTADKHSFFKFMVKSIAEKHGLRATFMPKPFKGLTGNGCHCHISVWDLAGEVNAFADNKAEFGLSAEGRHFLGGIMKHASALAAVTNPTVNSYKRINAPRTISGATWAPNSVTWTGNNRTHMVRVPGPGRFELRLPDGAVNPYLLQAIIIAAGLSGVRSKADPGRHYDIDMYKDGHKVTDAPKLPLNLLDALREYNRDEELQEALGREFSAAYLKLKQGEWNTYCSQFTEWEHQTTLDV
What is the function of this protein?
Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase III, GSIII.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
Protein: MINC_SHEON
Sequence: MSKPSLELKGATFTLSVLHINSSDLNAVMAELDSKLAQAPQFFLGAPLVVNLSAIQDSNFNLRGLKELLLSRQLVIVGITGATTVLSNQAKTLGLAIVKAGKQTASPPPAPRQTKVLKQNIRSGQQVYAKNGDLIIFGAVGNGAEVIADGSIHIYGALRGKAMAGAAGDTTAVIIAHSLEAELVSIAGQYWLAENLQQHSSDKSGCIRLNGESLIVESLPL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: GSTT1_DROYA
Sequence: MADFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQDYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNKWYENAKKVTPGWEENWAGCLEFKKYFE
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 1-1, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: FRSA_SALPA
Sequence: MTQANLSETLFKPRFKHTETSTLVRRFNRGSQPPMQSALDGKNVPHWYRMINRLMWIWRGVDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAKQAMDWQQKACQEQDAMRSGRYWLHASTLYNIAAYPHLKGDELAEQAQALANRAYEEAAQRLPGSLREMEFAVPGGSPVTAFLHMPKGDGPFPTVLMCGGLDAMQTDYYTLYERYFAPRGIAMLTLDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLEAPRLKAVACLGPVVHALLSDPQRQSTVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGFWKNDPFSPEEESRLITTSSSDGKLIEIPFNPVYRNFDHALQEITDWINHRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: PYRB_KLEP7
Sequence: MANPLYQKHIISINDLSREDLELVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGGVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMVGDLKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSELAL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MIAA_PSEU2
Sequence: MNALPPAIFLMGPTAAGKTDLAIELTKVLPCELISVDSALVYRGMDIGTAKPSKTQLAEHPHRLIDILDPAQSYSAADFRSDALAAMAEITARGNIPLLVGGTMLYFKALLDGLADMPAADAQVRAQLEADAQAFGWQALHDQLAVVDPVSAARIHPNDPQRLIRALEVYRVSGMSMTAHREQQTAQSTEAAASGRQQLPYTVANLAIAPADRKVLHQRIALRFEQMLDQGFLDEVLALRSRGDLHSGLPSIRAVGYRQVWDHLDGKLTRDEMQERGIIATRQLAKRQFTWLRSWDDLHWLDSLASDNLSRALKYLGSVSILS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TAM_RHOPA
Sequence: MADWNAEQYLKFEDERTRPARDLLAQVPTTAPRKVADIGCGPGNSTALLVERWPEASVIGVDTSADMLRQARERLPQHKFIEANVAHWAPPAGTDVLFANAVFQWVPDHLKQLRRLLSGLDSGGVLAVQMPDNLDEPSHIMMREVALQEPWRHQLSKAAELRDTLPKPSVYYDALKPLCSRLEIWHTVYNHALDGPEAIVEWVKGTGLRPFIDPLELPERKTYLAAYTARIAAAYPAQADGQVLLRFPRIFIVAVK
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_RUEPO
Sequence: MPKINGNEIRPGNVLEHNGGLWAAVKVDHVKPGKGGAFAQVELRNLRNGSKLNERFRSADKVERVRLEQKDQQFLYESDGMLVFMDAETYEQIELPADLLGERRPFLQDGMTILVEFYESEALNATLPQKVTCKIVETEPVVKGQTAANSFKPAVLDNGVKVMVPPFVGQDEMIVVNTETMEYSERA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I01A3
Sequence: MSLLTEVETPTRNEWECRCSGSSDPLVVASSIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: VSP1_BOTPA
Sequence: VIGGDECDINEHPFL
What is the function of this protein?
Thrombin-like enzyme that has high clotting activity upon bovine and human plasma.  Has also fibrinogenoltic activity by rapidly hydrolyzing Aalpha chain of fibrinogen (FGA), and partially consumes Bbeta chain (FGB).  Has high catalytic activity upon substrates such as TAME, and specific substrates for thrombin S-2238 and S-2288.  Also hydrolyzes specific substrates for kallikrein (S-2266 and S-2302), however, no release of kinin upon plasma has been determined.  When administered intraperitoneally in mice, causes defibrinogenation, making the plasma incoagulable.
What are the official names of this protein?
Thrombin-like enzyme BpSP-1, SVTLE BpSP-1, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP, Thrombin-like enzyme BpSP-I, SVTLE BpSP-I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUBB_PEA
Sequence: MASTFSATTSSCNLSSSAAISSFPLAAGKRNANKVVLPRKNRNVKVSAMAKELHFNKDGSAIKKLQNGVNKLADLVGVTLGPKGRNVVLESKYGSPKIVNDGVTVAKEVELEDPVENIGAKLVRQAAAKTNDLAGDGTTTSVVLAQGLIAEGVKVVAAGANPVLITRGIEKTSKALVAELKKMSKEVEDSELADVAAVSAGNNHEVGNMIAEALSKVGRKGVVTLEEGKSAENSLYVVEGMQFDRGYISPYFVTDSEKMTVEFENCKLLLVDKKITNARDLINILEDAIRSGFPIVIIAEDIEQEALATLVVNKLRGSLKIAALKAPGFGERKSQYLDDIAILTGGTVIREEVGLTLDKADKEVLGNAAKVVLTKDTTTIVGDGSTQEAVNKRVSQIKNQIEAAEQEYEKEKLSERIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKDTLANDEEKVGADIVKRALSYPLKLIAKNAGVNGSVVSEKVLSSDNPKYGYNAATGKYEDLMAAGIIDPTKVVRCCLEHASSVAKTFLMSDCVVVEIKEPESAPVGNPMDNSGYGNI
What is the function of this protein?
This protein binds RuBisCO small and large subunits and is implicated in the assembly of the enzyme oligomer.
What are the official names of this protein?
RuBisCO large subunit-binding protein subunit beta, chloroplastic, 60 kDa chaperonin subunit beta, CPN-60 beta.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DRE21_PICSI
Sequence: MEATVLLVTDSITLSSKVVTWAIQEFKEKADRGNNLCVLTQANSLEWKSYFSSSSLDVVVFFSEKCEFHKQNLVVELARILKPGGAVFIQTLVSMEDGTTKIHASLEHSLLLAGFVRPEVVASVEGLASSDGLELFALRAQKPTWETGSSFSLKKKSVQKQESLPKPGALSVKPEMNVDLEDLIDEESLLSEEDLKRPPLPSASDCEVSTKRKACKNCTCGRAELEEKQTKLGLTVEQLNNPQSACGNCGLGDAFRCSSCPYKGLSPFKLGEKVSLPGTLLTADM
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog 1, Fe-S cluster assembly protein DRE2 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.