PharMolix/UniProtQA huggingface dataset:
Protein: HIS1_SHEB5
Sequence: MTESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDMGIIGENVLEEEQIERQTLNKPADCLKLRQLDFGSCRLSLAVPTEFSYADASSLEGLRIATSYPNLLRRFMQQKGITYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQTQTPTKQALIDKILSRVNGVIRARESKYILLHAPTETLDQIVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKL_MYCBO
Sequence: MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEGTHKYAVHEIGQ
What is the function of this protein?
Not known, could be involved in the transport of ribonucleotides.
What are the official names of this protein?
Probable ribonucleotide transport ATP-binding protein mkl.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: COFH_METMJ
Sequence: MKCMPPPLREILDDVLAGHRLTEEEAVRLLATRDRGVWEIAAAANELRERKVGNVVTYVRNQNINVTNLCVNACGFCGFSRKPGDADAFFYGETAVRGKAREARERGVTEVCTVSGLHPEFDVQSYAEIYSWIRDEVPGVHIHASNPMEVAYAARRSGISTREVMELMRGAGLSTLCGTAAEILVDDVRRVICPDKIDTGSWARIIREAHGLGIRSTATIMYGHCESEADRARHLNILREIQDETHGFTEFVPLSFIHKNTPLYRAGLARAGATGREDLLMFAVARLFLDNFDHIQASWVKVGTKMAEMALLSGADDLGGTLFEESISREAGARDTDYLDPAEMRRMAEDLGRVLRQRTTTYALLPG
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
What are the official names of this protein?
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase, FO synthase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofH family.
Protein: KCY_CHLCV
Sequence: MIITIDGPSGTGKSTIAKALATELNFNYCNTGAMYRTLAYTHLQEPWQALPIKELIDNPPFSFSFISGQPLEAFLEGQLLSAELGTQEVANAASKLSQLPEVRSFMHKLQRKYAELGNCVFEGRDMGSKVFPDADVKIFLTASAEVRASRRLKDLPENSLSKEALHAELVKRDEADSQRLHDPLIIPEGAIILDSSDLTISQVLEKILALVSPNLP
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPFA_MYCTO
Sequence: MSGRHRKPTTSNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAVGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAPLAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAPPVELAVNDLPAPLGEPLPAAPADPAPPADLAPPAPADLAPPAPADLAPPAPADLAPPVELAVNDLPAPLGEPLPAAPAELAPPADLAPASADLAPPAPADLAPPAPAELAPPAPADLAPPAAVNEQTAPGDQPATAPGGPVGLATDLELPEPDPQPADAPPPGDVTEAPAETPQVSNIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG
What is the function of this protein?
Factor that stimulates resuscitation of dormant cells.  Has peptidoglycan (PG) hydrolytic activity (By similarity).
What are the official names of this protein?
Resuscitation-promoting factor RpfA.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. Rpf subfamily.
Protein: KA14_MESMA
Sequence: MKIFFAILLILAVCSMAIWTVNGTPFEVRCATDADCARKCPGNPPCRNGFCACT
What is the function of this protein?
Potassium channels inhibitor.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 14.x, BmKK14.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 14 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PRMA_BACHK
Sequence: MKWSEISIHTTEEAVEAVSHILHEAGASGVAIEDPAELTKEREQQYGEIYALNPDEYPAEGVLIKAYFPQTDSLHETIAGVKSSIDVLPSYDIEIGTGNITVNEVNEEDWATAWKKYYHPVQISDTFTIVPTWEEYTPSSPEEKIIELDPGMAFGTGTHPTTTMCIRALEKTVQPGDTIIDVGTGSGVLSIAAAKLGASSVQAYDLDPVAVESAEMNVRLNKTDDVVSVGQNSLLEGIEGPVDLIVANLLAEIILLFPEDAARVVKSGGLFITSGIIAAKEKVISEALEKAGFTIEEVLRMEDWVAIIARNA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_ECOLC
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_XENLA
Sequence: MSEDHVQNDSQIEAVFRVNDSHKHKKDKEHRHKEHKKDKDREKSKHNNSEHRDPSEKKHKDKHKNNDKHREKDGEKHRERDGEKHRDKNGEKHRDGEKHKEKDIEKHKEVEKHRVKDGEKHKEKDVEKHKEKDVEKHRDGEKHKHRDKDREKKKEEKMKSSSGGVKVKKENGFSSPVRVKDEPEDQGFYVSPKENKAMKRPREDDEDYKPKKIKSEDDKKGKKRKQEEEDIKPKKKSKAKGNEEGVKKKKVKKEEEEKWKWWEEERHRDGIKWKFLEHKGPVFAPPYEPVPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTTDERNLITNLSKCDFNAMSLYFKEQSEARKNMTKEEKLKIKAENERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDSKIPVAPAGHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKMCVEKIRNTYKEDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLFQELDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPDDDLFDRLNTSILNKHLQDLMEGLTAKVFRTYNASITLQQQLDELTNSDDNVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQGKIDAKKDQLADARREFKSAKADAKVRRDEKTKKLVESKKKAVQRIEEQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKYGVPIEKIYNKTQRKNLLGPSIWQTTTSNFNAEQRCFS
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  TThe free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.  May play a role in the circadian transcription of the core circadian clock component BMAL1.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MYRF1_CAEEL
Sequence: MSSSDLLKGEFDGLNSEHFNMMQYLTQDTDEDDGSMVSPTSSADSMHQNLGVQQQQQQMLQAQQRQNQNGIFQPRRFPESPAMTDPCGNVSSSSSSSHHSDPMFSPNEFNGYAGANDNGNQTMNNIQSQQLSQQQHQQTRGGNLMMPQQSSIHAQMQNMNAPQFWSQPGTAAVNQPTNTLAQLNLFNIIRGGADSGMPSPVLEMPRKRSRLDTPCETPRIAPSFAGIDGFPDENYSQQQAIRFSKFQEEQWSPLYDINAQPLQQLQVHVVADKGFNYNSNDNCFVNQKKNHFQISVNVEASDTMPPKYVNFNNRLVPIRDFKLSFCGVKAEMPSSEITIRQSRADRKPHTHTPVLFEIQERRMTKVCVPRLHFSETTLNNQRKQKNRPNPEQKFFLLVVRLFASIDESEHGVLIQSYASEKVIVRATNPGSFEPQDTDIGWQRNGGALYTQGAVSVGTEHQVESAKLTVAGDIYMSGRIINPSDIRLKEAITERETAEAIENLLKLRVVDYRYKPEVADIWGLDEQQRHRTGLIAQELQAVLPDAVRDIGDYLTIDEGRVFYETVMATQQLCRMTGDLDSKIDEKVAEISRRLNEYAVRKKLASSMASNLNGDNKSLSYSRCSLTSTATNATSQPKRSRKHRAIKQAQSCGSRLSQGTVVTLVSIMAACLLAMSALYVLDWHNRNYGYHQHFETNTPSTKGELANLVISPANFMPSFQPDAPILLEKCFNPSCKTYCCTDTPPVVEDSRAIATHGLDNGDEVYPESPSNRTNGIARAPNLEHMAFETGVEIRIPALNVTLDQRYCVERSCNKRKGIFNVFVPVSRYMPDVALEIEIKAPISKVVSNCGAFPSTEFNHKVCPLSRTQQSESPVPTSTRLFDNIFELSMGSFIQSAYRFRVGYSTETCFSEDSNGSYEEYNLIFYRMCTLSSS
What is the function of this protein?
Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531).  Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531, PubMed:33950834).  Acts in complex with myrf-2 paralog (PubMed:28441531).
What are the official names of this protein?
Myelin regulatory factor homolog 1, Polyglutamine-repeat protein 47.
What is the protein family that this protein belongs to?
Belongs to the MRF family.
What are the subcellular locations of this protein?
[Myelin regulatory factor homolog 1]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Apical cell membrane; Single-pass membrane protein. Note=In early L1 larvae, localizes to the cell membrane of the pharynx, epidermis, and neurons, but is not enriched in the nucleus or cytoplasm of these cell types (PubMed:33950834). Later in the L1 larval stage, accumulates in the nucleus of the pharynx, epidermis, and neurons (PubMed:33950834). SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 1, N-terminal]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Cytoplasm. Apical cell membrane. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage (PubMed:28441531). In early L1 larvae, localizes to the cell membrane of the pharynx, epidermis, and neurons, but is not enriched in the nucleus or cytoplasm of these cell types (PubMed:33950834). Cell membrane localization is promoted by pan- 1 (PubMed:33950834). Later in the L1 larval stage, accumulates in the nucleus of the pharynx, epidermis, and neurons (PubMed:33950834). SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 1, C-terminal]: Endoplasmic reticulum membrane; Single- pass membrane protein.
Protein: RISB_BORPD
Sequence: MNPYILTPDLNGEGLHIGIVRARFNEEIGQAELDACLQKLGELGVDERDIMVVTVPGALELGVALSHMAETFEFDALIALGAVIRGETYHFEVVSNEMARAISRISLETGIPVANGVLTVDTDEQAQARAAGKGGDCALVAVEMANLVAALEPEEDDEDEDEEDEDFDDEETDRR
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: IF1_PSEF5
Sequence: MSKEDSFEMEGTVVDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVRVELTPYDLSKGRITYRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT5_USTMA
Sequence: MDDNIEIKREDQTSHALVPDKDRKSRIQHGGKRPIDPFAAEDDDEEEERGDAVDEQDQDDDEDDDEDDDDDDDDEDDDEDDEEDDTARGQRRRAKKQRRNRFLDVEAEVDDDEEDLDEEEEELAREDGFIEEDIPDDTEDVQRRAAADNQRLDRFRRQEEDTNAEALAEELRQRYGRSARYAAQSDYAEVPQRLLMPSVEDPSLWGVPCKPGRERDIVMTLVRKAMAENFTSSPMRIISAFCRDSIPGRVYVEARRADDVVKACNGLAGAYARQTTSLHLIPISEMADLLKLQKVQNEIQVGGWVRIKRGKYAGDLAQVLDVSENGEEVGLKMIPRIDLNPKDSGLYTDSLGRKRKKGAGSSATTVAFRPPQRFFNPEEVQKAYPRDTPTKRGSQWVFQNDSYRDGYLEKDVRVTGIITENVNPTLDEITKFAGESSIEDGINKLGAVDLSLIADASKKATEALIQPKDQVEIFEGEQAGVYGTVKAINNEVITIQLEHEDLMDQIVEVPARSVRKRFKPGDHIKVMSGKHADETGLVVKVEDNVTTFLSDLSMQEVSVFSKDIRQAAEVGSGVNVISGYELHNLVQLDAQTVGIIFNIERESFKVLDQTGQVVTVKPHQISTKKDTSRAFALDHDGNEIRAGDMVKEVAGPFSRLRQGQVLHIYQSMVVFLHNREYTENGGVFIARARSLEPLAPKSVSTKTKKDGGDLSKMNPALSNLSGGGANDVRVEGVRRFGGRDMHKGKNVAIIKGPYKTYRGRITETTGNMARIELTSVSKPITVSLDWLVEKDPITGRSTKLNAGGFGGPSRGGHSGTGSRMGGASSNPYSSGSTSMGAGGRYNPYGGSQPAAAVGSYGGSSGTGAGGYGGYSQPVATSAAGASGYGGTGGIGARTPAYNPYAGDGGKTPAYNPYGDGGKTPAYNPLGDGGKTPAYNAAADGGRTPGYNPYAGDGW
What is the function of this protein?
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT5, Chromatin elongation factor SPT5.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS6_MYCA1
Sequence: MSPNSSGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRATMLDVVRRTAEQVFIPLTVGGGVRTVADVDVLLRAGADKVSVNTAAIARPELLEEMARQFGSQCIVLSVDARTVPPGAVPTPSGWEVTTHGGRRGTGIDAVEWASRGADLGVGEILLNSMDADGTKAGFDLEMLQAVRSAVTVPVIASGGAGAAEHFAPAIEAGADAVLAASVFHFRELTIGQVKAAMAEAGIPVRMVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LARG2_DANRE
Sequence: MLCPCRGKLKLLVVSLSFVILFTWLYLLVGNSENGRSLLLSACLVESTEARLLERDVLASRVREVEEENRQIRLQLSQSQGLAGQPAEGNYGNQQWVASADTGPEDVENTAEERANHSECSRSPTAEKCELLHVACVCAGHNASRDVVTLVKSILFHRRNPLHFHFITDTVANQILSTLFQSWMVPSVQVSFYDADELKSEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAIFRKFTEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLYLERLRRMGWEQMWRLTAERELMSMLSTSLADQDIFNAFIKQNPVLVHQLPCFWNVQLSDHTRSEQCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSQASSESTVLQQALEELDEDDQCYDFRRERIMLHRVHLYFLQYEYSPTDDGTDITLVAQLSMDRLQMLEAICKHWEGPISLALYMSDAEAQQFLRYAQASEVLKNRKNVGYHIVYKEGQFYPVNLVRNVALRNVNTPYVFLTDVDFLPMYGLYDYLRKSIVQLDMANTKKALVVPAFETLRYRLSFPKSKAELLSMLDMGTLYTFRYHVWTKGHAPTNYAKWRTATTPYKVEWEADFEPYVVVRRDCPEYDQRFVGFGWNKVSHIMELDAQEYDLIVLPNAFMIHMPHAPSFDISKFRSSPSYRYCLTTLKDEFHQDLSRKYGSAALKYLTAQRNI
What is the function of this protein?
Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner.  Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity).  Supports the maturation of DAG1 more effectively than LARGE1 (By similarity).  In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity).
What are the official names of this protein?
Xylosyl- and glucuronyltransferase LARGE2s, Glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: PHS_VIBVY
Sequence: MLDELKCEACSIDAIALTTQQQQELLLELEGWHLMEREGIPQLEKVYKFKNFMQAWQFSNQVAELAEQEFHHPSILLEWGKVTVTWWSHSIKGLHKNDFICAAKCDQIIR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ASAH2_CAEEL
Sequence: MKPVAISLSLLLLVTLLPGSEQRKVDNPDFQPNCLVGGPDIYDPAQSEKVLWFDVNLDLPPRQRFQQIAKAYKKEIHAVFDVLNYFLTIIPGVNAWELIGNMTASALDKGMIMNPYRDEVLGIAEVLDVPLGNLVFLNLFYEMSRFCTSIVAQTEDNKDLYHARNLDFGQLFVWDIAAQSWGLTEALKKVSVNINFFKNGKLLFKGSTLAGHVGVLTAMKPHKFSLSMNAKVQPDIINVAKWYMGAYENTDLQFVMYFDRWLFENCDDFQCAREKIAGVKLLTGAYFILGGANPGEGSVLVRNTTSVQFERKLFDGANDWFLLQTNYDPDKDPLFIDNRRDPGNACMNKLTRANVGMKGIFTVLSSKPNLNKTTVHTVIMSVTKGYFETFIQKCPNPCWAF
What is the function of this protein?
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
What are the official names of this protein?
Probable acid ceramidase, AC, ACDase, Acid CDase, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
Protein: RS8_STRSY
Sequence: MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIATILKNEGFVKNVEFIEDDKQGIIRVFLKYGPNGEKVITNLKRVSKPGLRVYSKREDIPKVLNGLGIAIISTSEGLLTDKQARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HIS7_PSESM
Sequence: MAERKAYVERNTLETQIKASINLDGTGKARFDIGVPFLEHMLDQIARHGLIDLDIECKGDLAIDDHHTVEDVGITVGQAFSQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHANVTLHIDNLRGTNTHHQIETVFKAFGRALRMAVELDERMAGQMPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_HELPJ
Sequence: MKEKTPTPMKNIRNFSIIAHIDHGKSTLADCLIAECNAISNREMKSQVMDTMDIEKERGITIKAQSVRLNYTFKGEDYVLNLIDTPGHVDFSYEVSRSLCSCEGALLVVDATQGVEAQTIANTYIALDNNLEILPVINKIDLPNANVLEVKQDIEDTIGIDWFNANEVSAKAKLGIKDLLEKIITTIPAPSGDPNNPLKALIYDSWFDNYLGALALVRIMDGSINTEQEILVMGTGKKHGVLGLYYPNPLKKIPTKSLECGEIGIVSLGLKSVTDIAVGDTLTDAENPTSKPIEGFMPAKPFVFAGLYPIETDRFEDLREALLKLQLNDCALNFEPESSVALGFGFRVGFLGLLHMEVIKERLEREFSLNLIATAPTVVYEVHLTDNSIKYVQNPSELPPENHIACIKEPFVRATIITPSEFLGNLMQLLNNKRGIQEKMEYLNQSRVMLTYSLPSNEIVMDFYDKLKSCTKGYASFDYEPIENREANLVKLDVRVAGDVVDALSIIIDKNKAYEKGRALVETMKELIPRQLFEVAIQASVGNKIIARETIKSVGKNVTAKCYGGDITRKRKLLEKQKEGKKRMKAIGKVELPQEAFLAILKID
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RHBC_RHIME
Sequence: MHAHNAATLTLRSLLNCVAREFPDHVRWLETQGHLRFMLTFPEGGGSLGLPAHYRSATGHHLFGEPVMLTDENGAKTVDAVEAISAVIERLEPSIAAKDGRVDLLNRTHSSRLLIEAALHARNGDLAALAGDEVSFVAAEQGLIAGHGIHPCPKSREGMTEAESRRYSPEFAAGFPLRWFAVESELFHTGHSQGSPSAEEWLKEAMGSDIDALKAPLPAGDFSLLPVHPWQADQMLKDPTVAALVAAGRMIDCGEAGKPWFPTSSVRTLYRPDASFMLKMSLGVGITNSVRVNLARELLRGDDMYRFRRHELWQDFSRSYPGLTLIPDPAFMGVKIDGALIDGLSVSMRENPFTGANADRNVSLLAAVCEHLPDRGSRLGALIRNRAHLERRPLDIVARDWFERFLTIFVRPIFGLYLRHGIAMEAHQQNIVVEIEHGYPIGLFYRDNQGFFHHERAHGALVEALPGFGEPSESVFGEEPVDERLLYYAFINSVLGMVGALGREGLVSETALLAMLRRELLRLEALEGANSGIVRKMLAPTLQCKANLKTRLARMDELVGPLETQSVYLQITNPLFETEKVLAHA
What are the official names of this protein?
Rhizobactin siderophore biosynthesis protein RhbC.
What is the protein family that this protein belongs to?
Belongs to the IucA/IucC family.
Protein: ID2_MOUSE
Sequence: MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKVLCG
What is the function of this protein?
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.  Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.  Inhibits skeletal muscle and cardiac myocyte differentiation.  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Restricts the CLOCK and BMAL1 localization to the cytoplasm.  Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
What are the official names of this protein?
DNA-binding protein inhibitor ID-2, Inhibitor of DNA binding 2, Inhibitor of differentiation 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KMO_AEDAE
Sequence: MTAQYKQTNTNGLTARNLNVAVVGGGLVGSLFALHLGKKGHTVDLYEYREDIRTAELVIGRSINLALSARGRKALAEVGLEDALLQHGIPMKGRMLHDLKGNRKIVPYDANTNQCIYSVGRKHLNEVLLDAAEKYPNIHLYFNKKLQSANLDEGEMSFIDPTTKESTHTKADLIVGCDGAYSAVRKEIVKRPGYDYSQTYIEHGYLELCIPPTKDGDFAMPHNYLHIWPRGKFMMIALPNQDRTWTVTLFMPFTNFNSIKCDGDLLKFFRTYFPDAIDLIGRERLVKDFFKTRPQSLVMIKCKPYNVGGKAVIIGDAAHAMVPFYGQGMNAGFEDCTVLTELFNQHGSDVDRILAEFSDTRWEDAHSICDLAMYNYVEMRDLVTKRSYLFRKKLDELLYWMLPNTWVPLYNSVSFSHMRYSKCIANRKWQDKILTRVLYCCSITAVAAAGYFGYKYGNMDLVQHYSSSVLQLLKLK
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Multi-pass membrane protein.