PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_ECO55
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ZURA_LISMO
Sequence: MKKIIEVNNVSYHYDKEHALENIHFQVAKGSFTGLIGPNGSGKSTMLKLILGVLKKQQGSISLFGEKQADFKDWVKIGFVSQKSNAFNSAFPATVKEVVASGLTKKKGLFKTLNNKDKEDIDYALKRVEMTDYLHRNIGELSGGQQQRVFIARALVSRPELLILDEPTVGVDVENVKAFYELLAELNRTEEMTLLLVTHDLMAVNTYVNHVISINKRIIFDGSAHEYQHYLADRELEILAEQRRREDACLDCDASPV
What is the function of this protein?
Involved in a zinc uptake transport system.
What are the official names of this protein?
Zinc uptake system ATP-binding protein ZurA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: RL18_RICB8
Sequence: MRSAKLKFEKRRSRIRHKIAKTANRARLSIFKSGRHIYAQIIDDTKSVTIASASTLDEKIKKLKKSHCNVENATKIGELIAEKAVSCGVEEVVFDRSGYKYHGVVKALADAARKKIRF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DUT_PHOLL
Sequence: MMKKIDVKILDPRIGEEFPLPTYATPGSAGLDLRACLDNAVELAPGQTELLPTGLAIHIGDEQLAAVILPRSGLGHKHGVVLGNLVGLIDSDYQGQLMVSVWNRGDKAFTIQPGERIAQIVFVPVVQAEFNLVEDFETSERGSGGFGHSGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RL18_SHESA
Sequence: MDKKTSRLRRAIRARKKIQELGVNRLVVHRTPRHIYAQVINPEAQVVAAASTVEKAVKEQLKSTGNVDAAKAVGKFIAERAIEKGVTTVAFDRSGFKYHGRVAALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TRPB_ECOL5
Sequence: MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETDVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CML7_ORYSJ
Sequence: MGGKELSEEQVASMREAFSLFDTDGDGRIAPSELGVLMRSLGGNPTQAQLRDIAAQEKLTAPFDFPRFLDLMRAHLRPEPFDRPLRDAFRVLDKDASGTVSVADLRHVLTSIGEKLEPHEFDEWIREVDVAPDGTIRYDDFIRRIVAK
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML7, Calmodulin-like protein 7.
Protein: GGLO_RAT
Sequence: MVHGYKGVQFQNWAKTYGCSPEVYYQPTSVEEVREVLALAREQKKKVKVVGGGHSPSDIACTDGFMIHMGKMNRVLQVDKEKKQITVEAGILLADLHPQLDEHGLAMSNLGAVSDVTVAGVIGSGTHNTGIKHGILATQVVALTLMTADGEVLECSESRNADVFQAARVHLGCLGIILTVTLQCVPQFHLQETSFPSTLKEVLDNLDSHLKRSEYFRFLWFPHTENVSIIYQDHTNKAPSSASNWFWDYAIGFYLLEFLLWTSTYLPCLVGWINRFFFWMLFNCKKESSNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEAHPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKFGGRPHWAKAHNCTQKDFEEMYPTFHKFCDIREKLDPTGMFLNSYLEKVFY
What is the function of this protein?
Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.
What are the official names of this protein?
L-gulonolactone oxidase, LGO, L-gulono-gamma-lactone oxidase, GLO.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: UGPA1_YEAST
Sequence: MSTKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSSKLDDAARAKFENELDSFFTLFRRYLVEKSSRTTLEWDKIKSPNPDEVVKYEIISQQPENVSNLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNTFLDLSVRQIEYLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSLLPVPTEYDSPLDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLIESSNLEMEIIPNQKTITRDGHEINVLQLETACGAAIRHFDGAHGVVVPRSRFLPVKTCSDLLLVKSDLFRLEHGSLKLDPSRFGPNPLIKLGSHFKKVSGFNARIPHIPKIVELDHLTITGNVFLGKDVTLRGTVIIVCSDGHKIDIPNGSILENVVVTGNLQILEH
What is the function of this protein?
Plays a central role as a glucosyl donor in cellular metabolic pathways.
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, UGPase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
Protein: CPNE9_HUMAN
Sequence: MSLGGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISDGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPANPSPIPAPEQP
What is the function of this protein?
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity).  Plays a role in dendrite formation by melanocytes (PubMed:23999003).
What are the official names of this protein?
Copine-9, Copine IX.
What is the protein family that this protein belongs to?
Belongs to the copine family.
Protein: SYE_ACIAD
Sequence: MKVRTRIAPSPTGFPHVGTAYIALFNLCFAKQHGGEFILRIEDTDQLRSTPESEQMILDSLRWLGLNWSEGPDVGGPHAPYRQSERMGIYKQYALDLIEKGHAFYCFATAEELDQMRAEQQARGETPKYDGRGLKLSQEEVERRLAAGEPHVIRMKVPEEGICKFNDLLRGEVEIPWAQVDMQVLLKTDGLPTYHLANVVDDHLMEITHVLRGEEWLPSAPKHQLLYQYFGWDMPTLCHMPLLRNPDKSKLSKRKNPTSINYYRDIGVLPEALLNYLGRMGWSMPDEREVFTLTDMIEHFDIQRVSLGGPIFDVDKLNWLNGQWIKSLTPGQLLDRLLSWKSDRQTLEDIATAIQPRINLLSEAVNWAGFYFNHMPNITAEMFESKKLSPEQVRQSLQFAIWRLESQFTWNNETVSQILMDLANQMDIKLRDFMPAFFIAIAGSTSSTPVMQSMVTIGPDLTFARLRRALEIVGAPSKKELKVWEKLNESLKLPKNETVDNT
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_STRPD
Sequence: MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSNEDVNDFAKNLLAAKRELTYCSICGNLTDDDPCHICTDTSRDQTTILVVEDAKDVSAMEKIQEYHGYYHVLHGLISPMNGVGPDDINLKSLITRLMDGKVSEVIVATNATADGEATSMYISRVLKPAGIKVTRLARGLAVGSDIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: TOP6B_ORYSJ
Sequence: MDDDAGDGAASGGTKRKVTAASSSAAAKGKAAGKGKAASKASALATAKESSLLKQKSPAEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPDIEIIIEEITKSKFNTMIGLVDRQRIDEELYDDFESAKAREKRLAKEARFQETQAKNAALGKKVKEAPAARGKGRGEAAFFRVTCKDNGRGMPHDDIPNMLGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLPIEIKSSMKGQNFISFCLLDIDIHKNVPHVHLHEKRENKDRWHGAELQVIIEGNWTTHRSKILHYMRQMAVITPYAQFLFRFLSDSPDKNLTIQFARRTDVMPPIPLQTKHHPSAVDLLLIKRLISETTKQNLLQFLQHEFVNISKSHAERLIGEMGPDFSAKTTVKSLTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGISIGGKDVKHGLNIFRYANRIPLLFEQGADVITRTALKRINWSSYKINQQQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIASAVQSALKQCCLQLKSKIVKKLQARERQDRKRNLNRYIPDVARAIMETLGEIADESPPKRPRYDKEDEELLEKVNSEEVTEMTFRDCLTQHVEQVDYEMALEYAMQSGVSEEPREALYLNSLEGSYKFIDFQSPVFVFRFIP
What is the function of this protein?
Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles.  Relaxes both positive and negative superturns and exhibits a strong decatenase activity.  The B subunit binds ATP (By similarity).
What are the official names of this protein?
DNA topoisomerase 6 subunit B, OsTOP6B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR9_RHIL3
Sequence: MAVISKKIPAPDKVEIKTALISVFDKTGIVDLARALSARGVRLLSTGGTFKAITAAGLAVTDVSEITGFPEIMDGRVKTLHPTVHGGLLAIRDDSEHQDAMKQHGIEGIDLAVINLYPFEEVRAAGGDYPTTVENIDIGGPAMIRASAKNHAYVTTLTDPADYAELLEQLSADDGKTAYTFRQRMAAKAYARTAAYDAMISNWFAETLSIDTPRHRVIGGALKEEMRYGENPHQKAAFYVTGEKRPGVSTAALLQGKQLSYNNINDTDAAYELVAEFLPEKAPACAIIKHANPCGVATGSSLVEAYRRALACDSVSAFGGIIALNQTLDAETAEEIVKLFTEVIIAPDVTEEAKAIVARKPNLRLLSAGGLPDPRAVGLTAKTVSGGLLVQSRDNGMVEDLELKVVTRRAPTAQELDDMKFAFKVGKHVKSNAVVYAKDGQTAGIGAGQMSRVDSARIAALKAEEAAKALGLAVPMTHGSAVASEAFLPFADGLLSMIAAGATAVIQPGGSMRDQEVIDAANEHGVAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: USTYB_ASPFN
Sequence: MPSDGNHLTRSTGGNGFIAVNQTERYTLPPPIKQLALEGQDPRTDNPGTDGTGAVHICKDFDGILAWADSRRLVDAKHN
What is the function of this protein?
Oxidase; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide (PubMed:24841822, PubMed:27166860, PubMed:26703898).  First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-terminal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) (PubMed:24841822).  Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI (PubMed:24841822).  To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline (PubMed:24841822).  One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH (PubMed:24841822).  Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F (PubMed:27166860, PubMed:26703898).  For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization (PubMed:27166860).  UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations (PubMed:27166860).  N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H (PubMed:27166860).  The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H (PubMed:27166860).  Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B (PubMed:27166860).
What are the official names of this protein?
Oxidase ustYb, Ustiloxin B biosynthesis protein Yb.
Protein: AROE_STRTD
Sequence: MRIDGHTRLAAVVASPIKHSISPFIHNLAFEKTHVNGVYVAWEIPESDLAETVENIRRYNMFGINLSMPYKEKVIPFLDGLSPEAQLIGAVNTVVNRDGRLIGHNTDGFGFFASLKNFNPKDTHIMILGAGGAAKSIVTQAVLDGAKKVSIYVRPQSLVKAKENFRTLLDQTDCYLEFHDLTDADHFQKELRQTDLLVNATSVGMDGESLPISIDTRFPKELLVADIIYQPFETPFLALARKQEIEAVNGLGMLLYQAAGAFKLWTGENMPTGAIWQELENIYNS
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MURC_STRZJ
Sequence: MSKTYHFIGIKGSGMSALALMLYQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFSGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_CLOPE
Sequence: MIADKLFEKVEKNGVVCVGLDTSLDYIPEEFKSKFSNESDMLFAFNKEIIDATLDVSACFKVQIAYYEALGLKGLEAYKNTLSYLREKNALIIADIKRGDIAATAKMYAKAHFEGDFESDFITLNPYMGMDSIDPYLPYIEKNEKGVFVLVRTSNKGAEDIEYLEAGHGKKVYDVVGEKLNTLGKNYLGKHGYSSIGGVVGCTHQEEAKEMRDKLDTMPFLIPGYGAQGGTAKDVAAYLKNGNGGIVNSSRKILLAYKAMEDNKNFAECARKEAISMRDSIREAILK
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: KCY_XANOR
Sequence: MTDLSPVLTIDGPSGAGKGTVSRIVAARLGWHYLDSGALYRAVGVAASWADLDVSDPAALVRCTFDTKVEFDDAGEAGLRVLVNGADVTSELRLETTGALASAIAAIPEVRSALKERQRAFRRAPGLVADGRDMGTVIFPDAAFKVFLTASAEERAGRRHKQLMEKGVSVTFADLLREIMARDARDAQRVVAPLRSAKDAVLIDTSGIGVEDVVQRVVGLLADRTPS
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y058_RHOPB
Sequence: MTEAWRYSAQGISVALRVTPRGGRDDIDGLETLANGRTVVKVRVRAIAEGGEANRAVTELLAKALGVPKRAVRVLSGTTSRLKQVAVDGDPNELGEALRKLTAPKPD
What are the official names of this protein?
UPF0235 protein RPC_0058.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: TF3C4_HUMAN
Sequence: MNTADQARVGPADDGPAPSGEEEGEGGGEAGGKEPAADAAPGPSAAFRLMVTRREPAVKLQYAVSGLEPLAWSEDHRVSVSTARSIAVLELICDVHNPGQDLVIHRTSVPAPLNSCLLKVGSKTEVAECKEKFAASKDPTVSQTFMLDRVFNPEGKALPPMRGFKYTSWSPMGCDANGRCLLAALTMDNRLTIQANLNRLQWVQLVDLTEIYGERLYETSYRLSKNEAPEGNLGDFAEFQRRHSMQTPVRMEWSGICTTQQVKHNNECRDVGSVLLAVLFENGNIAVWQFQLPFVGKESISSCNTIESGITSPSVLFWWEYEHNNRKMSGLIVGSAFGPIKILPVNLKAVKGYFTLRQPVILWKEMDQLPVHSIKCVPLYHPYQKCSCSLVVAARGSYVFWCLLLISKAGLNVHNSHVTGLHSLPIVSMTADKQNGTVYTCSSDGKVRQLIPIFTDVALKFEHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMINGLHPVNKNYQVQFVTLKTFEEAAAQLLESSVQNLFKQVDLIDLVRWKILKDKHIPQFLQEALEKKIESSGVTYFWRFKLFLLRILYQSMQKTPSEALWKPTHEDSKILLVDSPGMGNADDEQQEEGTSSKQVVKQGLQERSKEGDVEEPTDDSLPTTGDAGGREPMEEKLLEIQGKIEAVEMHLTREHMKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEEYDDRTARVLIGHISKKMNKQTFPEHCSLCKEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSLIYRRCLLHDSIARHPAPEDPDWIKRLLQSPCPFCDSPVF
What is the function of this protein?
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.  Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3.  May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F.  May be localized close to the A box.
What are the official names of this protein?
General transcription factor 3C polypeptide 4, TF3C-delta, Transcription factor IIIC 90 kDa subunit, TFIIIC 90 kDa subunit, TFIIIC90, Transcription factor IIIC subunit delta.
What is the protein family that this protein belongs to?
Belongs to the TFIIIC subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_PROM3
Sequence: MARAFPLERVRNIGIAAHIDAGKTTCTERILFYSGVVHKMGEVHDGAAVTDWMAQERERGITITAAAISTTWNDHRINIIDTPGHVDFTIEVERSMRVLDGVIAVFCAVGGVQPQSETVWRQADRYSVPRMVFVNKMDRTGADFLKVHGQIKNRLKANAIPIQLPIGAEGDLSGIIDLVKNKAFIYKDDLGKDIEETEIPDHMKELAAEWRAKLMECVAETDEELIEVFLETEELSEAQLASGIREGVLNHGLVPLLCGSAFKNKGVQLLLDAVVDYLPAPVDVPPIQGLLPNGKEAVRPSDDNAPFSALAFKVMADPYGKLTFVRMYSGVLEKGSYVLNSTKNEKERISRLIILKADDREEVDALRAGDLGAVLGLKNTTTGDTLCTTDDPIVLETLYIPEPVISVAVEPKTKGDMEKLSKALLSLAEEDPTFRVSTDPETSQTVIAGMGELHLEILVDRMLREFKVEANIGAPQVSYRETIRASSKGEGKFARQTGGKGQYGHVVIEMEPGEPGSGFEFVNKIVGGIVPKEYIKPAESGMRETCESGVIAGYPLIDVKVTMVDGSYHDVDSSEMAFKIAGSMAFKDGVKKCNPVLLEPMMKVEVEIPEDFLGSIIGDLSSRRGQVEGQSIDDGLSKVQSKVPLAEMFGYATQLRSMTQGRGIFSMEFSHYEEVPRNVAEAIISKNQGNS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_PROMT
Sequence: MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKELEEKRNSLQAQGNSIGKEVGQKIKQGLPHDSEEISNLRVKGNQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGKNEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSVIAKSRFVTLFKHAAKLERSLINFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITSLHRGEIIPRDLLPLRYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPERSEDALEQITSDAESVLQELELPYRVIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGDFQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILENGQQSDGSINLPKALIPYFGSNKLKPE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP2C2_RABIT
Sequence: MDLVVVLGLCLSCLLLPSLWKQSHGGGKLPPGPTPFPILGNVLQLDFKDLSKSLTNLSKVYGPVFTVYLGMKPTVVVHGYEAVKEALVDLGHELSGRSRFLVTAKLNKGFGVIFSNGKRWTETRRFSLMTLRNFGMGKRSIEERVQEEAHCLVEELRKTNASPCDPTFILGAAPCNVICSVIFQNRFDYTDQDFLSLMGKFNENFKILNSPWVQFCNCFPILFDYFPGSHRKAVKNIFYVKNYITEQIKEHQKSLDINNPRDFIDCFLIKMEQEKCNQQSEFTIENLLTTVSDVFMAGTETTSTTLRYGLLLLMKHPEVIAKVQEEIERVIGRHRSPCMQDRSRMPYTDATVHEIQRYINLIPNNVPHTTICNLKFRNYLIPKGTDVLTSLSSVLHDDKEFPNPDRFDPGHFLDASGNFRKSDYFMPFSTGKRVCVGEALARMELFLFLTAILQNFTPKPLVNPNNVDENPFSSGIVRVPPLYRVSFIPV
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.  In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.
What are the official names of this protein?
Cytochrome P450 2C2, CYPIIC2, Cytochrome P450 PBc2, Cytochrome P450 PHP2, Laurate omega-1 hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: HRCA_STAA3
Sequence: MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFNNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLLNTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RS20_XANC5
Sequence: MANIKSAKKRAKQTIVRNERNTGQRSMLRTAVKKVIKALDANDAAGAEAAFAVAQPILDRFSARGLIHKNKAARHKSRLTARIKAIKAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.