PharMolix/UniProtQA huggingface dataset:
Protein: VTC1_TRYB2
Sequence: MASVIEKGLASICCVTTSSKPWAEGEADGDVKYEDLRGPGGRNTSGSVSDKRICVPQKIDPKTFFANERTFLKWMSISVMIGMMSLTLLNFGDTSSNASELAGLVLLPVSILFMIHSLFVFKDRANKIYMREPMRYDDTKGPTILVLVLGVSLGIAAIFSVQKQYYRTASSSFNDGPRFS
What is the function of this protein?
Accessory subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation.  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen.  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase.  VTC1 contributes only 3 transmembrane domains to the complex.  The VTC complex also plays a role in vacuolar membrane fusion.
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 1, SPX-dependent polyphosphate polymerase VTC subunit 1, Vacuolar membrane polyphosphate polymerase accessory subunit 1, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC1 family.
Protein: CDC23_MOUSE
Sequence: MAANSSVVSVAAAATAVPGVSTVADFSDLQEIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLSELQPPPPLTEEDAQDVDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSRKHQARGLDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKKALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGETVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTSDTPGTFFLPASLSANNTPTRRVSPLNLSSVTP
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8.
What is the protein family that this protein belongs to?
Belongs to the APC8/CDC23 family.
Protein: RUVB_ENT38
Sequence: MIEADRLISAASNQPEDVVDRAIRPKLLEEYIGQPQVRSQMEIFIQAAKLRGEALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVGRSARFMGLELSDEGAFEVAKRSRGTPRIANRLLRRVRDFAEVKHDGTISLDVAAQALDMLNVDAEGFDYMDRKLLLAILDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATVRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: KDPA_SALCH
Sequence: MAAQGFLLIASFLLILLVLAKPLGSGLARLIAAVPLPGVAGVERILWRTLGITDHEMNWRQYLLALLTLNLLGLGILFCLLFWQEWLPLNPQRLPGLSWDLALNTAVSFVTNTNWQAYSGESTLSHFSQMAGLTVQNFLSAATGIAVVFALIRAFTRQNVHTLGNAWQDLVRITLWILFPVALIIALFFIQQGVPQNLSAYQPITTLEGAKQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPTALTNLAQMLAIFLIPAALCFAFGEAAGDRRQGRALLWAMSFIFVVCVAVVMWAEVQGNPHLLAAGADSSVNMEGKETRFGVLASSLFAVVTTAASCGAVNAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMLLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKMTALAILVTPMLVLLGSALAMMTDAGRSAMLNPGPHGFSEVLYAVSSAANNNGSAFAGLSANSPFWNCLLAFCMFVGRFGVIIPVMAIAGSLVSKKVQPASQGTLATHGALFIGLLIGTVLLVGALTFIPALALGPVAEHFSLP
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEF_XYLFM
Sequence: MNTSHYSVLGHTVPYPKVYDPSLLFPISRAVGRTQIGIGVVLPFVGEDRWHAYELSWLDARGKPCVATATFHVPCDSPYLIESKSLKLYLNSFSAEVFNRAEALRLRIAADLSACAGAAVAVEFGLPPVGGGDKEISLDRLNVDIEDYGPPNPDYLSNVAQNFVEEMVEETLTSTLFKSNCPVTGQPDWASVTVRYFGVPIDHEGLLRYFISFRHHAEFHEQCVERIFQDVLQRCAPQCLAVEARYTRRGGLDINPLRTTSEMAWPLSVFRDPRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_LIGS1
Sequence: MGRLMGLDVGSRTVGVAVSDMLGWTAQGVEIVQINEDEQEFGLDRIAELVKENEVVGFVLGLPKNMNNTSGPRVEAAKAYGELLEEKFNLPIDFIDERLTTVEAERMLVEQADASRKKRKKVIDKLAASLILQNYLDAKGKLLKELN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPP5_ASPFU
Sequence: MGAFRWLSIAAAASTALALTPEQLITAPRRSEAIPDPSGKVAVFSTSQYSFETHKRTSWWSLLDLKTGQTKVLTNDSSVSEIVWLSDDSILYVNSTNADIPGGVELWVTQASSFAKGYKAASLPASFSGLKTAKTKSGDIRFVAYGQSYPNGTAYNEELATAPLSSARIYDSIYVRHWDYWLSTTFNAVFSGTLKKGHGKNGYSLDGELKNLVSPVKNAESPYPPFGGASDYDLSPDGKWVAFKSKAPELPKANFTTSYIYLVPHDASETARPINGPDSPGTPKGIKGDSSSPVFSPNGDKLAYFQMRDETYESDRRVLYVYSLGSKKTIPSVAGDWDRSPDSVKWTPDGKTLIVGSEDLGRTRLFSLPANAKDDYKPKNFTDGGSASAYYFLPDSSLLVTGSALWTNWNVYTAKPEKGVIKKIASANEIDPELKGLGPSDISEFYFQGNFTDIHAWVIYPENFDKSKKYPLIFFIHGGPQGNWADGWSTRWNPKAWADQGYVVVAPNPTGSTGFGQALTDAIQNNWGGAPYDDLVKCWEYVHENLDYVDTDHGVAAGASYGGFMINWIQGSPLGRKFKALVSHDGTFVADAKVSTEELWFMQREFNGTFWDARDNYRRWDPSAPERILQFATPMLVIHSDKDYRLPVAEGLSLFNVLQERGVPSRFLNFPDENHWVVNPENSLVWHQQALGWINKYSGVEKSNPNAVSLEDTVVPVVNYN
What is the function of this protein?
May be involved in metabolism of dipeptides or may affect host defense mechanisms.  Has a substrate specificity limited to the hydrolysis of X-Ala, His-Ser, and Ser-Tyr dipeptides at a neutral pH optimum (By similarity).
What are the official names of this protein?
Dipeptidyl-peptidase 5, Dipeptidyl-peptidase V, DPP V, DppV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP6_DICDI
Sequence: MKSLFEQFEIDLYCIIITRFFDISITTITVYLGLLMVIVIGMYKVSLYKATIIGGNNWQHIGEMIYEFVVDLIIEQVGKPGILFFPFIMSLFLFVLTLNVMGLIPLSFTVTGQLLVTFTLAITIMIGITIWGFRIHGIKFLNIFVPSGIEPWLLPLLVFIEIMSYVLRPISLAVRLFANMLAGHLLIHIIGVAAIYLMQFYFIGILPWICVIAFMFLELGIAFLQAYVFVLLTLIYIANIINLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y106_DICNV
Sequence: MNTSLQDLEQEILAAVRHEVVPALGCTEPICVALAAAIGRTHLSSAPEKIAVRVSGNLMKNAMGVTVPGTGMVGLSIAAAVGAIGGDAEAGLQTLKSISAEDVAAAKKMLADDAVSVSMADTDHIFYAEVTLTAGAEIARVCIADTHTNVVLIEKNGKTIYQKPVAAADEKNPVAVFTKITAKDVFDFATTVDLEKIRFIKEAATLNSALSQEGLRTDYGLHIGRSLQKNIGNGLLSDDLLNRIIIETGAASDARMGGASLPAMSNSGSGNQGIAATMPVVVVARHLKSSEEKTIRALFLSHALAIYIHAKLPTLSSLCAANTAAMGSAGACAWLFSERFEAVSDTICSMIGDVSGMICDGAANSCAMKVISSITSGYKSMLMALDNTRVTGFEGIVEHDLERSINNLCALARESMQHVDQQIIDIMVQKPMH
What are the official names of this protein?
UPF0597 protein DNO_0106.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: YWLA_BACSU
Sequence: MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLIFALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVLTALIYWIWDSVLLQKKEA
What are the official names of this protein?
UPF0715 membrane protein YwlA.
What is the protein family that this protein belongs to?
Belongs to the UPF0715 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS2_CUTAK
Sequence: MAVVTTRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLHQSLTYIDKAYAFVKETVAKGGQILFVGTKKQAQESIVEQATRVGMPYVNQRWLGGMLTNFQTISKRIARLKELEAMDFDKVSGSGLTKKELLMLSREKDKLEKDLGGIRDMPKVPQAVWVVDTKKEHLAIDEARKLKIPVVAILDTNCDPDEVDYAIPGNDDAIRSVSLLTRIIADAAAEGLMARSAGKSGEQPAEAEPMPDWERELLEGDGAKTEAKAEEPKAEAKKADEAPEAEKSN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LAMB_ECOLU
Sequence: MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQTTGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAGGSSSFASNNIYDYTNETANDVFDVRLAQMEINPGGTLELGVDYGRANLRDNYRLVDGASKDGWLFTAEHTQSVLKGFNKFVVQYATDSMTSQGKGLSQGSGVAFDNEKFAYNINNNGHMLRILDHGAISMGDNWDMMYVGMYQDINWDNDNGTKWWTVGIRPMYKWTPIMSTVMEIGYDNVESQRTGDKNNQYKITLAQQWQAGDSIWSRPAIRVFATYAKWDEKWGYDYNGDSKVNPNYGKAVPADFNGGSFGRGDSDEWTFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: MZM1_PHANO
Sequence: MSREMALVAYRNLLRSARVAFQGDMNTLFAARAEVRRNFESNRSLTAGSDELSKQLTHAEEVAKFLRENVVQGQAADDEGSYKLRIHEHTERGNNEDIRKGKGKSTLGRVKCCSS
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL4_BDEBA
Sequence: MATVNVLNWKKEKVGSVELAADVFETPVKKEVLHTVVQWQLAARRQGTHMTKTKGLVSGGGKKPFKQKGTGGARQGSSRSILMPGGGTAFGPQPRSYAFVLPKKVRRLGLSMALSHLQKEGKLFIVDSMASEGKTAELNKRLQAFGLKKAVLVDSVVDDKFNRASKNLPTFKYFPVEGLNVFDLLKYDAAVITKDSVAKIVDRCSLEKA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MIAB_THET2
Sequence: MPPCYPFLLSWEGWARDPPGRPGGAMRAHIITYGCQMNEYDSHLVASELVSLGWELVDSVEEADFVLVNTCAVRGKPVEKVRSLLGQLRKEKERRGLLIGMMGCLAQLDEGQQMAKKFGVDVLLGPGALTSLPEALKANERFFDLTFREDVLDYIPPPPKGALSAHVTIIRGCNHHCTYCIVPTTRGPEVSRHPDLILKEIELLKQAGVVEVTLLGQNVNSYGKDQPGFPSFAELLRMVGGMGIPRVRFLTSHPVNFTDDIIEAIAETPAICRYIHLPVQSGSDRVLRRMAREYRRAHYLERIRKIREALPDAVLSTDIIVGFPGETEEDFQETLSLYDEVGYDQAYMFIYSPRPGTPAYKHFQDLPREVKVERLMRLIEKQKEWSYRRNLEWVGKTVEVLVRGEAKEEGFVQGHDRGNHPVLVPASQAPVPGLYQVEIKQATPHLLFGEVVGAEAPAPIPLPVA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB1_LISIN
Sequence: MKKNIGTIISISGFVLKIEFNESELPEISHALEYKTHQGTYLAEVVQHTGINTVSAIAIGEVSGLARGAEVINLGHPIEVPVGETVQGRMLNVYGKAIDGLPEPEAEVKWPIFREQPLLRELDTNKEILYTGIKVIDLICPILKGGKTGLFGGAGVGKSVLMQELINNISMMGGNSVFTGVGERVREGIGLYNELESSGVLPQTTVVLGQMNESPGVRMRVALTGLTIAEYLRDEEKKDVLLFIDNVFRFIQAGSEVSSLQGKIPITGGYQSTLSKEVGDFQDRIASTKNGSITSIQCVFLPADDIDDPSAVATFSHLDSTIVLERSIAALGIFPAVNPLQSFSRALNPTFVGERHYQLAVQVKFILQRYMELQEIINVLGMAELSDEDKKLVHRARKIRNFLSQPFYVSEKFTGTEGIFVEIEDLLSSVERILNGEYDERSEREFLFIGSYKDLK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AZOR1_XANAC
Sequence: MKLLHLDSSALGANSISRELSAAVVEQQRRLHPEVDVSYRDLDRDPIPHLTAQTLAQTDPAEAAAAEAVMQQFLQADVIVIGAPMYNFAIPSTLKAWIDRIAVAGRTFQYTANGPEGLAGGKRVIIASARGGLYADPTNDFQEPYLRQVLGFLGVDDISFVRAEGVAYSPQHRADALASALAGLSEEEAAAGA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: ISPF_ALKMQ
Sequence: MRVGIGYDVHRLVEGRKLIVGGVEIPHEKGLLGHSDADVLLHAIKDALLGAVALGDIGKHFPDTDEKYKGESSLYLLNEVGRMLAEKAYVANNIDATIIAQEPKMAPYIELMRRNIAEVLGIKVEQVNIKATTTEGIGFVGRGEGIAAQAIVSVGQSLG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: GSTT1_HUMAN
Sequence: MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide.  Displays glutathione peroxidase activity with cumene hydroperoxide.
What are the official names of this protein?
Glutathione S-transferase theta-1, GST class-theta-1, Glutathione transferase T1-1.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEPI_ECOUT
Sequence: MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: T2R60_PONPY
Sequence: MNGDHMVLGSSMTDEKAIILVIILLLLCLVAIAGNCFITAALGMEWVLQRMLLPCDKLLVSLGASRFCPQWVVMGKTTYVFLYPTAFPYNPVLRFLAFQWDLLNAATLWFSTWLSVFYCVKIATFTHPVFLWLKHKLSEWVPWMLFSSVGLSSFTTILFFIGNHRVYQSYLRNHLQPWNVTGNSIWSYCEKFYLFPLKMITWTMPTAVFFICMILLITSLGRHMKKALLTNSGFRDPSVQAHIKAMLALLSFAMLFISYFLSLVFSAAGIFPPLDFKFWVWESVIYLCAAVHPIILLFSNRRLRAVLKRCRSSRCGTP
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 60, T2R60, T2R56.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GLNB_RHORT
Sequence: MKKIEAIIKPFKLDEVKEALHEIGLQGITVTEAKGFGRQKGHTELYRGAEYVVDFLPKVKIELVIEDALVERAIEAIQQAAQTGRIGDGKIFVYAIEEAIRIRTGERGGDAI
What is the function of this protein?
P-II indirectly controls the transcription of the glutamine synthetase gene (glnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA.  When P-II is uridylylated to P-II-UMP, these events are reversed.  When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase, so activating the enzyme.
What are the official names of this protein?
Nitrogen regulatory protein P-II.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: RSGA_RUMCH
Sequence: MQLGIILKGIGGFYYVKQEKTEDIFECKPRGVFRKNSVTPLPGDRVGFSIIDGDKKLGNIDEILPRSSELVRPAVANVDQIAIIVAAKAPNPDYMLLDKLLITAETRNIRVLICVNKIDLDDDTAKIVRNAYSPAGYDVIEISSVRNIGYKRLKEELKGHITVFAGQSGVGKSTILNHIMESWVMETGSVSNKIERGKHTTRHAELLELKYGGYVADTPGFSSFEIIDIPYNQLERYYPEFLPYINTCRFNSCSHITEPGCRVIEALERSEIDNNRYQRYIQLYKALKDIPQYKGKKTESRRVIK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_LISIN
Sequence: MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVNNIIMPFVGVLLGGLDFSDLSFKVGKSVIQYGAFIQSIVDFVIIAFAIFIFVKVLTSFIKKKEQPTEETPVPPTEEYLKEIRDLLKEQQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAD_LEUMM
Sequence: MAKNLILLGLPGAGKGTQADFIVKDYSIVHISTGDIFRANLAENTELGQKARQFMDAGDLVPDEITNAMVADRLNQQDVETGFMLDGYPRNEAQAVFLDKYLSDNGKSVSATLYFEVADTLLRERLLGRGRADDTPEVIDNRLAVNKAANLPLVDYYQKAGVLHTIDGGRELADVYHDVKEVLDNLN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2BS3_PARAN
Sequence: MPRSPAKTSPRKGSPRKGSPRKGSPSRKASPKRGGKGAKRAGKGGRRRRVVKRRRRRRESYGIYIYKVLKQVHPDTGISSRAMSVMNSFVNDVFERIASEASRLTSANRRSTVSSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTTSR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.3, sperm.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.