PharMolix/UniProtQA huggingface dataset:
Protein: DAZP1_MOUSE
Sequence: MNSAGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNIDPKPCTPRGMQPERTRPKEGWQKGPRSDSSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKNQAPGQPGASQWGSRVAPSAANGWAGQPPPTWQQGYGPQGMWVPAGQAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPPPQGFPQGYGAPPQFSFGYGPPPPPPDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDMSKPPTAQPDFPYGQYGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRGQNHNVQGFHPYRR
What is the function of this protein?
RNA-binding protein, which may be required during spermatogenesis.
What are the official names of this protein?
DAZ-associated protein 1, Deleted in azoospermia-associated protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm.
Protein: AMPA_CUTAK
Sequence: MRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPTVQGLAPRAVKEAEETFGAPLVEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGESLRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAEGALLGCYKVPTITATSNEPEISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDVTVDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLNIKTAANMYTMKCDMGGAAAVLAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTMYDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTLTGACMVALGNHTAGVMTSGAQAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTPGIDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6870_RHOOB
Sequence: MSGHSKWATTKHKKAVIDAKRGKAFAKLIKNIEVAARTGGGDPAGNPTLYDAIQKAKKTSVPNDNIERARKRGAGEEAGGADWQTIMYEGYGPNGVAVLIECLTDNRNRAAGEVRTAMTRNGGNMADPGSVSYLFTRKGVVTLEKGDQTEDDVLMAVLDAGAEEVTDLGETFEIVSEPTDLVAVRSALQEAGIDYDSAEADFRASVEVPVDADGARKVFKLVDALEESDDVQNVYTNVDLSDEVLAELDD
What are the official names of this protein?
Probable transcriptional regulatory protein ROP_68700.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM182_HUMAN
Sequence: MRLNIAIFFGALFGALGVLLFLVAFGSDYWLLATEVGRCSGEKNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHNSTSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQAVADMESYRNMKMKDCLDFTPSVLYGWSFFLAPAGIFFSLLAGLLFLVVGWHIQIHH
What is the function of this protein?
Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (By similarity).  Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (By similarity).
What are the official names of this protein?
Transmembrane protein 182.
What is the protein family that this protein belongs to?
Belongs to the TMEM182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS13_PSEA7
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQNICAATGVNPAAKIKDLSDEQIDQLRNEVAKHTTEGDLRREINMNIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: TAF2_SCHPO
Sequence: MSQLVDVPARGHQKVAIDIDFASQTIIGRTDITVNPIDSNLQKIVLDCYQAEIHSVYVNGDLTKFSYSDALKKLRIDEPNSTVNQHHQLNLQYEALMNDLGGINIFLSKPPGDELRPLIVSIDFSVHQPIFGITFVGIDPVDHRYPHVFTNNSIIPYSTCSWLPCVDGIWERSTWEFEITLPKTLSSLMHREKTQPSDLNNGANGVDGHDDNYENNRFDHQFNLSNEPDLLEDHDIEVICCGDLLDQVTHPKDMRKKTVYFSVTTPVAPNYIAFAAGPFKHINLTDFREPEDDDAMGSSAIDITGYYLPKYAEEVENTCVFLYKAMDFFVREYGSYPFNSFKLCFVDETNFPIISTPSLVISSNSILYPKDSLDQIYDSTKTLTWALASQWIGVYLIPKAWSDLWLIYGLSYYICGLFLKKLMGNNDYRFRLKKQVYRLLELDIGKPPISQRNINIPIDPNTLDFIALKSPLVIHILERRLTKTGGSLGMSRVIPKLLLQVMSGDMLNGCLSTSHFLKTCEKASHMRLDVFAQQWIYGYGYPIFRVVQRFNRKKMIIEMGIDQVQTKEAPRAPMSDKNFLSDAIRHLNNESIPTGLPVFSGPMTIRIHEADGTPYEHVVELKDSFTKLDIQYNTKYKRISRNRSTKNVKRDGDHNGDDSDYVIRSLGDVLQSDEDIERWHLYDYTKEEEDTMATEAFEWIRVDADFEWICDLRVRQPEHMYVSQLQQDRDVVAQLETIRHFTSESFTVSQQVSTVLLRTLLDNRYYYGIRQEAARALARCAIPELDWVGYYHLRMAYLEKFCFKDSTIPKSNDFSNITEYYVKCAMLESFPNIRDRKGVTPSSVKKLLLDLLCYNDNANNEFSDAYFICLLIDSLVEGLIPRGETVQYAFSDPEHMEFVNQVINEIDRYMRIDACMPSFKNIITCKSLKAKLRLAQTFHLEFGPKELLPYTQEGNYVLVRCIAFNLMLQAGALKYTPLIKYIFYILTNDLSPVVRRSLLYSVQDGLGALARGGTKSDVASEDLIVEEDITKAVEKRIDITSRASISGAIEALRNDLGQNHDFATEIWNAINNPKSDLLTKRNLLMICRVLYKAKSSLLVTLKIPSLIPRLRAIHLGKGKIVIKKAPLKQITSKTKEKSTSPTPPSITINPIKPKGPTLKIKLTNLRSTPPSH
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of transcription (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 2, TBP-associated factor 2.
What is the protein family that this protein belongs to?
Belongs to the TAF2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at the barrier septum.
Protein: XPOT_CANAL
Sequence: MEQQIHQAVEIALSGTADPTLKNQAFEFINHIKSTEEGYKACVDILIKSSNESINDGLKFFVYQVIDENIDKLSQEQVFTLNQELFKCLSSYINNNLQDPTHLRNKFAQILAKQFCQVYINIYPNFIKDLLELINVSEATSTNPNNLLAIDYYTRVLIGIHSEIGDKYITRSQEIHNRNNLLKDAIRTQDMQQMVTSWIQILTNPSFAHSEEILNNTLKIVGQYVSWMEISLFISPEFINTVFSFLQNSKLRNTTCETLIDIISKKMAPQNKLELLSLLNLTEFIGTLNLIEKNKNDDDDEDEDVEFMEFVAKLLNQIGQELLIVLENQSGLLEQVNAQLFKLWPAILGCLNHNYDDVSQNVFPFLQQFLTLSKKNPQLYTVDLMSTLLNKLILKMRFDDDDDGVSDEDTQAQFLDFRAKLKSFQDTIALLEPQLYLEAIPVIINESIFETNVDDVNWRKVELGLYQLNGFSDSIRNNVFQISRNEINQSKPYLIFQEFLIKLINSDLIMKINHPMIQSNFFELIVKHYNFLVSRESNFELIIKILQIFTSPLGLFNENEKVRIRSWYLFFRFIKLTKPKLDNEALIESIVVKMQPLLVIKAELPTKDEDDDIVENGNFNNQQYLFETMGLLISLIPNELSQLKSKLIDLIFQPIFNDLEKCISIPESQREPIVILQAHHSLQAIGTLVRGYDYESGLKFLPDVVAKIDNAAQVVLITLENFSSHEMIRDATRFAFARFIPIFKSDNDNNNKNNLIISQHLSKLITIIWSSSNLKISEYSDFLSFLGQIVHNFRTDDNIYQLLNNFITPLFQKIFQVLQNPVTEDENLRPDIIRDKNSLKRATLNFISSIVMNHLSSLLITESNKQELPEIIGKVFEYSYDLSDTTTSKLAIVQLTNFVNVFGGSGGKLDDKEDKYSENLPPIEGIDEFLINKVINLSFELPFQKQEFNLNDAQYRLIAQEIAILLKSFELKKHDEFIVVLSNYLLNMGLSQDLCNDFCLNLHNLDLKDFKKYFISFINKMKSGK
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: ACPS_HELAH
Sequence: MIGIDIVSIARVERCVKRFKMKFLERFLSPSEILLCRDKSSTIAGFFALKEACSKALQVGIGKELSFLDMCISKSPKNAPLITLSKEKMNYFNIQSLSASISHDAGFAIAVVVVS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_CLOBH
Sequence: MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIGKQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDKVSRRIVNEVKEVNRIVYDVTSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: TIS11_DROME
Sequence: MSADILQKSREQDDSHYFERGDISKYVTMNDHLGDFDCNEVRKEIRMLLAHGANLDQQHQQQPHRHHGGLTRTISQPAQLIQQQQQQHQQQQQQQPAVASLVTITENLGNMNLHRKLERTQSEPLPPQQPMNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQAAKSSTQSQSQSQQSSSQNFSPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKSNSSASSTSSASGMGLGMSMGIGQGMIIGQGLGMGHHGPATPPESPNVPISPVHTPPPYDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDTPRLPVFNRLSSGVEAYQQQSNLGL
What are the official names of this protein?
Protein TIS11, dTIS11.
What are the subcellular locations of this protein?
Nucleus.
Protein: SDHD_ECOK1
Sequence: MENAKMNSLIAQYPLVEDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAAAGGIIESELVAIPAMQKRLEKEYHQPIAGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLEDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVNADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLSWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNATHLVWATGGGMVPEEEMNQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: CUE2_CONIM
Sequence: MARFLSILLCFAMATGLAAGIRYPDRVLGRCSTHDLSKMEIDTNLDGVYSPHRSFCTCGSGEVYFTAKDRRNHSNYRVYVCGMPTEFCTAENPVRDPKKGNRWLQCRCRQYKMVIYRDWLVLCE
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Im14.2, Conopeptide im025.
Protein: TDA11_YEASA
Sequence: MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNNEEI
What are the official names of this protein?
Topoisomerase I damage affected protein 11.
What is the protein family that this protein belongs to?
Belongs to the TDA11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_STRR6
Sequence: MTRYKATISYDGYAFAGFQRQSHARSVQEEIEKTLTRLNKGQTITVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHCRYAKHSKTYEFIVDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTASGTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQIDLILEKKDRQLAGPTAAPNGLYLKEIRYEE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: L_GOGV
Sequence: MSSICPEDSELERLKGLVLEVLSYERDLYRPGWISNTAGEMAMNAIKLRSTIHELNCCRDTGLKHNNDLKEMNELFDEAIGSHETVKTIVPDGYLIDKNNNVLTVLEVSTRTEPSDQTKKVQLDRLKYDGFENLLRPLGWTLNVITISEKKPRIGRIPEILMFKLLSTSLSILSYTTDICNWISEEDYLELKKSLTSYDFRTLTEEFKGQRLLFDIESAEDPYKDLFDWMLKNSEKLPFSLNWEGPKITEMIQDFKREDKQLRLLEIMRSAVTGLNFRTNHLSLLNKLKSLNLLNTRRKQNKVYDYIALMLFVRDSEIHDFPKGWFPSVNDRLVRVDSVDSPLSVYKKLVERMIKSLQSLQNEVGSKQKLGELKILIKFLEESSNNFIEPPVLKTMYFGLPARVLVPQPSLCLKIINDVPYEPQTTIVTSDETDTIEKVALNLILSQKTRSTPRASMSEEFFFQSVNGCLLLYKCTGEGQKAFSILCKSYKQGELRYSFYSFNINPSRLFPLIFSAKPIANLVDQLIMLINPICEDAERLQETIKRQESVNEFLISSEYSDKQIDDLKVKVTYLIYGILTTPTKRLQIELQSQRYYIMDTLSIIHHKDLKAKVIGNCITYDEYYLRDLAHGLINEILSCKNIGLFLKVTWALNISYLCHLITKETPDRLSDLRDCYEKFFKPKFQFMSNMIYDCKSVDELVERMEQEVNDFIQCEEPSFETKPFLYEPILADFLKWISTEKFNGIDGEQLLNPKDYLTSNIDVLDLTSNKSTFKRSKNHHMNDVLDQQYDTEKLLKRVISERLHKRITKSTKAGDDPSTAKSFKSGGESVKERNWKAGGEKRKKTRLAYEEFLGIVQGLIVETDSEEDLNDFLLQINKCLHEIDDELKKMNPKEINDLQKTKYCLVLDVIRELLGPEVCDLVRSTCYSTKLSDLPTDLLRKEAYERIVGETMSRAPLEFPRNVDTIDVTNISAGMVVTKYELKEFFSSFKFLLLWAGFNNFQGTYDHRSGPQSSFLSISNKYRGESMLSTRVTNSEALQDRLIAIKYGAPTLRNILFSTLNLEMKNSEIGPNNKPLQFGLAIKEQVGGPRELYVGDSDTKLITRVLEETSRNIGNRLNNSCLNSDKKFSNFMKRIARSFFENEIVLSMDHSKWGPFNSPLQYHLMFEAMESINDTDGRRLDFSFAKTILKWHLFKAVETPQILAEDVILSSLDVSLGRRDRQIGKERTFETFMVDAVLSNKPVPSQIHSWFDMGQGILHHTSDLYGSLASEYITKKIKEIFGVRSSTMNTSDDMVLLFHIKYKNEDSNQKDELLLITNFLCLVSNCLNKHISPKFCCSPLVGEFKSHFEVEATMVPLFTKFFAASINNFRCKTPMELFNTCDAIVEQGICNGMSLKVADSLKGRMVEMLGWLGYVADPLMKPVESRQQDWLEGCLSYRKLRSLESWLMDLGIGKLKLDVLKLELLKVIKELRESSIAPSVAYNKMVDISKSELGEITLWFPTLNGEFKLIVRSKLNLGTTINETCENLLIKKLINHYSRYSKQGLGLLIAEGLERSAFQSSVVTGFIGLSISLSGACIRKGDGTFLTLKESKNVVKPVAEVFPSLVMQSVCAVGDWVCGVESEMDKQMNKSIYMRTSLVNTAEFRFGLDELTAAIEMTMPDLFDKYLKDIVPPDKRLLMRHSWKVRPEMELLIECANKGLSIFDGRIDRQEEAVVLVDYYEPGRLLRRTMKLEKRGPERTARKGLQAIVNRMILDSILEPKIIDKTMVMDATKLAPYEGSMEDLKSHGESGVRRYIQQVLLGRESHYRQKEDEPNEITSSNVVVYGRGTPEFPLEDGTWLRGAKLGTSNPIKLQCCLQQISNDLKIQATLITHTGRAHYQDFMFLKRVIISDSDFDEPEILDTLEFRDVVVVENSKPNGKPCFLFMGCVIPLESDLVGSIMTHMSEAEWEELWKLVRTYFITRMKGEISCLPKARFDALWGMVSRIFGYSTVEKVVTMGFHQLDSFAEFLTFTDRVFTTKGPTLVFHRLKGLLVSYPAGPLLYKGHRLMLYKDWASGTPEPETLED
What is the function of this protein?
RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome.  During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral transcription.  The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated.  The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped.  As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated.
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the Arenaviridae RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: SUMO2_HUMAN
Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494).  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629).  Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
What are the official names of this protein?
Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, Smt3B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.
Protein: PYRB_BUCA5
Sequence: MRNSLYKKNIISINDLQRNELELVLNKSAMLKRTPQPNLLKNKVIASCFFEASTRTRLSFETAIYRLGASIVGFSDGNNISLEKKGETLTDTISVISSYVDAIIIRHPQEGSARLAAEFSNKKPIFNAGDGANQHPTQTLLDLFTIQETQNRLTQLNIAIVGDLKYGRTVHSLTQALAKFKHNKFYFISPDALKMPNYINNMLDKKEIYWKRHNNIEEIISEIDILYMTRIQKERLDSTEYANAKSKFVLRAAILKNARNNMKILHPLPRIDEIDRDVDYTPYAWYFKQAANGIYARQAILSLVLIEKHL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL19_AKKM8
Sequence: MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGIVIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIGKDAMIVKSANR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MLTC_SALCH
Sequence: MKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVLIAGPKDYVKYTDQFQTRSHINFDDGAITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDLYSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYLLKTRLKSRSNGLSIIYSVTINLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SYP_MICAN
Sequence: MRLSQQLFVTLREDPAEAEIPSHKCLVRAGYIRRIGSGIYAYLPLMWRVLQKVSQIVREEMNKAGAQECLLPQLQPAELWQESGRWDTYTKAEGIMFALTDRQNRELGLGPTHEEVITAVARDLIRSYRQLPVNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFNLDEECLKKTYQAMDIAYRNIFRRCGLAFRAVEADSGAIGGSASQEFMVLADAGEDEVLFTADEKYAANVEKAVSLPADKVASPFKKFAKKETPNTNTIESLAKFLDCAATAIVKNVLYEVVYDSGITVLVLVSIRGDQEVNEVKLQNELVRQASRYNAKTILALKIPDAAAQQKWATKPLPLGYIGPDLEDNLLKKASDIAPQFLRIADNTVTDLENLITGANETGFHLVGANWGKDFILPELIVDLRKAQVGDRAIHDPNQTLQSARGIEVGHIFQLGYKYSQAMNAFYTNEAGESTPICMGCYGIGVSRLAQAAVEQSYDKDGIIWPVAIAPYQAIVVIPNLADAEQVKTAESLYNELNQAGIETLLDDRDERAGVKFKDADLIGIPYRIVTGKSLKSGKVELVERASKKASEVAINEVVSYLKTAISKVNASD
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_LEIXX
Sequence: MSDDPTTPELESESESELAFEGALRPRTLAEFVGQAKVRGQLQLLLTAARMQERTADHILLAGPPGLGKTTLAMIVAHESDRPLRLSSGPAIQHAGDLAALLSSLTPGEVLFIDEIHRMARTAEEMLYLAMEDFRIDIMVGKGAGATSIPLDLAPFTLVGATTRSGLLPNPLRDRFGFTAHLEFYDEGELAQVLARAAVMLEFEIDGEALAEIAGRCRGTPRIANRLLRRVRDYALVHGGRADIAAVHAALELYDVNELGLDRLDRAVLHAILERFEGGPVGLNTLAVSVGEEPETIESVVEPFLVRIGLLSRTPRGRVATVAAWRHFGLAAPRQGHSQPPSLMDDL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HEM3_KORVE
Sequence: MATLRIGSRGSQLALWQANHISALLRERGHEVELEIIKTTGDKILDVALAKVGTKGMFTKEIEEALAAGKVDVAVHSLKDLPTELPQGFELAAVTKRENPRDVFLSVKYDSISGLPQGAKVGTSSLRRQAQIKAIRPDLEIFPLRGNVDTRVRKLEQGEYDAIILAFAGLNRLGKTQLVKEIISEDVMCPAAGQGALGIEIRLGDTRMREILSFLNDYDARATTTAERALLNQLGGGCQVPIGAFAEVKDGQVHLTAICARPDGSEILRESKSGADPAHLGEEVGKTLLARGATKILEDVYSQNIAAPAQP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL39_THEAC
Sequence: MSRNKELGRKIRLMKKIKQNRRVPGWVMMRTARKVTQNPLRRNWRRGSLKI
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: RL20_CHRVO
Sequence: MPRVKRGVTARARHKKILALAKGYRGRRKNVYRIAKQAVMKAGQYAYRDRRQKKRQFRQLWIARINAAARENGLPYSKFMNGLKKAAIEIDRKVLADLAVFDKPAFAQIVEKAKASLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.