PharMolix/UniProtQA huggingface dataset:
Protein: SLX1_CRYNB
Sequence: MSDDAEVTNNKKTTKSTLLDGNHIFPPFYACYLLRSKATANSNRTYVGSTPDPPRRIRQHNGELKQGAWSTSRHRPWEMQMIVYGFPSKLAALQFEWAWQKPELSRHLRIRGEDQEYYHIFTKDARRNWVERKVCVAYALISLTPFNRLPLHVRFFNHETHGIWQSIHEQAGVNTIQRGKSRAKPVNPLHLLSQSVAPAVTIILDLGGVSGTSGKRRECTKGVMSHEGPIDVKDVEFRQGFGVRGKWLEIRKRILSGQDLCCHLCQERIAFNDHLTFSICPLAESQDCFCITHLICLAKHFQDEAPVEDRRAPSQPKILPYQGLCPNCKRTVQWGQHIRACYARKEQVEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAGRKVRQREMKTKKGDQSNGTVAQPESIYSATPVHTTFGLSNASATLIDPSMPARSMKSKDVGGEGIRHSTHTDDSDGIISVYSETEDESESEPEWEIFEAEMMALS
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RK22_OLIPU
Sequence: MIKKRKKKSYTSVYALGQYISMSAHKARRVIDQIRGRSYEEALMILELMPYRGCYPIFKLVYSAAANASHNKGFKETNLVISKAEVNQGNTVKKLKPRARGRSYPIKRSTCHITIVLEDISFYQQYEEYLMYLKKPGCRNENRNLTCYDTYSSGGLWDKK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PG108_VAR67
Sequence: MATVNKTPVIVVPVIDRPPSETFPNLHEHINDQKFDDVKDNEVMPEKRNVVIVKDDPDHYKDYAFIHWTGGNIRNDDKYTHFFSGFCNTMCTEETKRNIARHLALWDSKFFTELENKKVEYVVIVENDNVIEDITFLRPVLKAMHDKKIDILQMREIITGNKVKTELVMDKNHVIFTYTGGYDVSLSAYIIRVTTALNIVDEIIKSGGLSSGFYFEIARIENEIKINRQIMDNSAKYVEHDPRLVAEHRFENMKPNFWSRIGTAAVKRYPGVMYAFTTPLISFFGLFDINVIGLIVILFIMFMLIFNVKSKLLWFLTGTFVTAFI
What is the function of this protein?
Envelope protein that binds to heparan sulfate on the cell surface and might provide virion attachment to target cell.
What are the official names of this protein?
Envelope protein H3, Ag35, Virion envelope protein p35.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG108 family.
Protein: RL2_PSEAE
Sequence: MAIVKCKPTSAGRRFVVKVVNQELHKGAPYAPLLEKKSKSGGRNNNGRITTRHIGGGHKQHYRLVDFRRNKDGIPAIVERVEYDPNRTAHIALLKYADGERRYIIAPKGVAAGDQLISGIGAPIKAGNSMPLRNIPVGSTVHGIELKPGKGAQIARSAGASAQLVAREGAYVTLRLRSGEMRKVLAECRATLGEVSNSEHSLRSLGKAGATRWRGVRPTVRGVAMNPVDHPHGGGEGRTSAGRHPVSPWGLQTKGKKTRSNKRTDNMIVRRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: BAMC_PASMU
Sequence: MKKWLFPFAFVATLAGCSVSNESKQQANDTYQKSDAALPLFAPLNTAGVSLPKQDTTYQLPQVKVKKADQVDIRPPETPLAIIQNSIAQFDGERALIAYPIDKREVYNLQQVARLLKEQGIGYQLTNEKIVTDWAPTGRADEIGDTQVRYEIEQVSSGNYSALFVSILQMKRNEVVFSPHLADKQRYSSDRLNQLVGELDASYRKQVRDLNNSGLMPIQSVLGTDSNGRTALVLGAPFNHAWTKLGQVLPQLEFDIKDEIIGRGVRELKYRPAGAKSWWWPFGRAEGSSGLKTGTYFMQLSALGKQSAVVMTDDDGNALSGEQAQALYQALQNLLAK
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamC.
What is the protein family that this protein belongs to?
Belongs to the BamC family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: MEU14_SCHPO
Sequence: MPKSSNLKMQRKGSLRENGLVKGLNKNKFSISKLKELSHADDSRKSHRIIRSGKSSGEAYKQAGKGLMNLGNHLSDWGAKSSNLSLNDISDKIGVLVSELGETEIEFVKAFNENRIKFKAIRAMEDSIAPSRAHRQRLISSIEREEERDPLSPKLTDLQNQLVRTEAENLVGEMQLDNTSREVFKSSFQGLMDAFQLRAQKQMTLSYYASQLAELINDEVAYPGDNPAAYSQKYATQIMHQCVESMARLLAPVTSETTEHVGSDCEFTRKSSSSVEFSDHSQDSGDPSQQNILQVKNVQAVLSIPEAESYKAQLLSSIAEEQKKKELQAKSTVFL
What is the function of this protein?
Has a role in nuclear division during meiosis II where it stabilizes the proper segregation of the spindle pole bodies.  Also has a role in the formation and extension of the forespore membrane.
What are the official names of this protein?
Meiotic expression up-regulated protein 14.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Prospore membrane.
Protein: KITH_SHV1
Sequence: MSGTAGTSRILRVYLDGPHGVGKSTTAEALVARCEPRRPIRSMLQEPMAYWRSTFASDAITEIYDTQHRLDSNEITAAEAGAFMTSLQLHMGTPYALLEEAMRPHVGRELAEPDDNGPLPQRRDFVLVVDRHAVASMVCYPLARFMMGCVSLRSVASLISHLPPPLPGTNLVVASLDFREHAARLRARARPGERLDLTMMAAIRNAYAMLANTSRYLLSGGDWRRDWGSLPVFKPSAFVARAAKTAYTLPLRDEPGLADTLFAALKVPEFLDARGYPRAAHAWTLDILANRIRALRVYTLDLTGPPEACAAAFRRLCAGLVLTEGSHPGALCELKRAAAAYAREMSVVGSREPTTAEVESA
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: RS16_SHEFN
Sequence: MVTIRLARGGAKKRPFYNIVVADSRNARDGRFIERVGFFNPLARGQEETLRLDLDRVEHWVATGAATSERVAKLIKDARKAVA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: TM86B_BOVIN
Sequence: MDARKEGLLRKPRFSAQPRVGMGLLPFFLACAVYLLVRNADQPPWVNVLLKILPVLYLAGFLGTAHPGGGYRALLQGALLCSAVGDACLVWPEALRYGMAAFGLAHLLYLRAFGLTPLKPGLLLPLLLVSALYFRVLHPHMPPQVVWPLLAYSIVLVAMLWRGLARGGSAHWGALLFVLSDSVLAWNIFTYLVPHGHLLVMTTYYSAQMLITLSAFQNPRLKSH
What is the function of this protein?
Enzyme catalyzing the degradation of lysoplasmalogen.  Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens.  May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
What are the official names of this protein?
Lysoplasmalogenase, Transmembrane protein 86B.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasm.
Protein: RS5_MANSM
Sequence: MANIEKQAGELQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALHEGTLQHPVKGIHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVRNVLSKAYGSTNPINVVRATIDALANMKSPEMVAAKRGKTVDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: CDC6D_HALMA
Sequence: MTDKSNNPAPASDPSTTETSNDADGSDGQLDAETDPGTSTGPSDLDDVILDNLDAGSDDPSDEASRGLFDDLLEGEPIFENKEVLRPSYTPHKLPHREEQINNMATILVTALRGDTPSNILIYGKTGTGKTASAKFVSEELETTSQKYEVPCEVEYINCEVTDTQYRVLAQLANKFIDKNAQLIDDRIAELEELQSQARENTAALEETAFGSLDDVEAEIESLEADKSEFEEVPMTGWPTDRVYSSFFDAVDYHERVVVIMLDEIDKLVEKSGDDTLYNLSRMNSELENSRVSIMGISNDLKFTDFLDPRVKSSLGEEEIVFPPYDANQLRDILQARSDVAFKGDALTEDVIPLCAAFAAQEHGDARRALDLLRTAGELAERDQTDNVLEDHVRQAQEKIELDRVVEVVRTLPTQSKIVLFAIILLEKNGVHNINTGEVFNIYKNLCEEIDADILTQRRVTDLISELDMLGIVNAVVVSKGRYGRTKEISLSVPTEETEAVLLSDSRLGDIDDVQPFVQARFDN
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 4.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: MDTL_SHIF8
Sequence: MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKMADRSGRKPVAIPGSALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPASPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTFSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPR1_ARATH
Sequence: MGRGNSCGGGQSSLDYLFGGDAPAPKPVPAPRPAPTESNNGPAPPVTAVTATALTTATTSVEPAELNKQIPAGIKTPVNNYARAEGQNTGNFLTDRPSTKVHAAPGGGSSLDYLFTGGK
What is the function of this protein?
Required for directional control of cell elongation.  Stabilizes growing ends of cortical microtubules and influences their dynamic properties.  Acts redundantly with SP1Ls in maintaining the cortical microtubules organization essential for anisotropic cell growth.  Plays a key role in salt stress-induced microtubules disassembly.
What are the official names of this protein?
Protein SPIRAL1, Protein NAP16kDa.
What is the protein family that this protein belongs to?
Belongs to the SPIRAL1 family.
Protein: GATC_STRSV
Sequence: MKITQEEVSHVAKLSKLAFSPEETAEFATTLTKIVDMVELLNEVDTEGVPFTSNVAANINYMREDVAQPGWNREELFQNVPEKERGYIKVPAILDDGGDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RS8_BACCZ
Sequence: MVMTDPIADMLTRIRNANMVRHEKLEVPASKIKKEIAELLKREGFIRDVEYIEDNKQGILRIFLKYGANNERVITGLKRISKPGLRVYAKADEVPRVLNGLGIALVSTSKGVMTDKDARQLQTGGEVVAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NAGZ_NEIG1
Sequence: MTVPHIPRGPVMADIAAFRLTEEEKQRLLDPAIGGIILFRRNFQNIEQLKTLTAEIKALRTPELIIAVDHEGGRVQRFIEGFTRLPAMNVLGQIWDKDGASAAETAAGQVGRVLATELSACGIDLSFTPVLDLDWGNCAVIGNRSFHRNPEAVARLALALQKGLAKGGMKSCGKHFPGHGFVEGDSHLVLPEDGRSLDELEAADLAPFRIMSREGMAAVMPAHVVYPQVDTKPAGFSEIWLKQILRRDIGFKGVIFSDDLTMEGACGAGGIKERARISFEAGCDIVLVCNRPDLVDELRDGFTIPDNQDLAGRWQYMENSLGHEAVQAVMQTMGFQAAQAFVAGLASPQDTAGGVKVGEAF
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_ALBFT
Sequence: MNKRHSGQRVVVGLSGGVDSAVTAWLLKQQGYEVIGIFMKNWEDDDDSEYCSSNVDFIDAAAVADVIGIEIEHVNFAAEYKDRVFAEFLREYQAGRTPNPDILCNAEIKFKAFLDHALRLGAQKIATGHYARVRCVAADGRVLDAAQAQMSDGRFELLKGLDPSKDQSYFLHRLNQAQLSKTLFPVGELLKTEVRRLALEIGLPNAKKKDSTGICFIGERPFRDFLNRYIAREPGPIKDDKGRTIGQHVGLSFYTLGQRQGLGIGGLKAKGAQRGGGEHAPWFVARKDLATNTLWVVQGHEHPWLQSHGLSAQDASWVAGTAPQAGRFSAKTRYRQLDAPCTLAAGAGAAFHLSFPEPQWAVTPGQSAVLYDDEVCLGGGVIAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_PSET1
Sequence: MFELTKRIDSNTQDAVFDTLTLPYELRIRGRLKAVTDNGHDVGLFLDRGPVLRNGDLLRASSGEVFSISAADEPVTTAYIENGLPLARLCYHLGNRHVSLAIGVDADGRHWIRFPPDHVLEELAILLGAQLTHHQAPFDPESGAYAHAGREQSHAHSHEHSHADGHTHAH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3B_NOSS1
Sequence: MIVVQKQLINSQIKSPQVFLIDHENNNRGLIDTYEALQLAQSVELDLVVVSQSKDTPVAKILNYGKLQYQKKKRQGQSARPTVKEVRFRPNVGAADYNLRIEQALQWLSKGDSVKFAIRLRGRENQYREQAGQMLERIVTDLSQVGKVQSLDKRSLIVQIMPA
What are the official names of this protein?
Translation initiation factor IF-3-like.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
Protein: NU1M_MAMPR
Sequence: MFLINVLTVTLPILLAVAFLTLVERKALGYMQLRKGPNVVGPYGLLQPIADAIKLFTKEPVYPQTSSKFLFTIAPILALTLALTVWAPLPMPYPLINLNLSLLFILAMSSLMVYSILWSGWASNSKYALMGALRAVAQTISYEVSMTTIILSMVLMNGSFTLTAFATTQEHLWLIFPMWPLMMMWFTSTLAETNRAPFDLTEGESELVSGFNVEYSAGPFALFFMAEYANIIMMNALTVILFMGTSCNPQMPEISTINFVVKTMILTICFLWVRASYPRFRYDQLMYLLWKNFLPLTLALCMWHISILISLACIPPQA
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEUD_CLAM3
Sequence: MEPITRVTGTGVPLKRSNVDTDQIVPSQFLKRVTKTGFEDALFFQWRKDPAFFVNQPAYEGATVLVAGPDFGTGSSREHAVWALRDYGFRAVLSPRFGDIFRGNSGKQGLLTGIVTEDDVERLWAAMDAEPGLDLTVDLVERIATAPGLTVPFEIDEYTRWRLLEGLDDIALTLRDEDAITTFEHRRASWRPRTLPARPAALEN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RNFE_GLAP5
Sequence: MQETQIPITQIDETPKAVEPSVWKNLFTQGVWTNNSTLVQLLGLCPLLAVSNNVTNALGLGLATLLVLTITNTIISLFRKVIPHDIRIPIYVMIIATAVTTIQLLMNAFAFPVYQSLGIFVPLIVTNCIVIGRAEAFASKNSVAHSAFDGFAMGLGMTLSLVVLGAIREIIGNGTLFDGLDLLLGSWAKALRMDLLHLDSGLLLAILPPGAFIGLGLILAVKNIIDRKK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL20_SHIF8
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTTLVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: HEM3_SHEHH
Sequence: MSQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKGLFVKELEVAMLEGKADIAVHSMKDVPVEFPEGLGLEVICEREDPRDAFVSNTYKTIEDLPQGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLDAGNYDAIILAAAGLKRLKLEERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEGGCQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITAASSGNKADAEKLGVALAEELLAKGAKTILDAVYANA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NTAL_HUMAN
Sequence: MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA
What is the function of this protein?
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.  Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
What are the official names of this protein?
Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Protein: RNH_SALEP
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAILRYRGHEKTFSEGYTLTTNNRMELMAAIVALEALKEHCEVTLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWKRLDAALGQHQIKWVWVKGHAGHPENERCDELARAAAMNPTQEDSGYQAEA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_LISMH
Sequence: MKRKIIVGSRRSKLALTQSNWVINKLKENYPAFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDKTIDFAVHSMKDVPSSLKEGLVIGAIPKRESPLDCFVFNQVNALDELPHGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHAENFDAIILAKAGLARMGWLENTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATKANEAVHFKGLVGNADGSIILEAEQTGANPSEIGNKVAEDLLSKGADTIIQELRNI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: VIAA_ECOLU
Sequence: MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSRLKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSTITSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTAAGRLWDMSAGQLKRGDYQLIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMETFRTLVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESWREKVIERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYIMLFSTEIVRYELSGPQGIEQAIRFLSQQFRGGTDLASCFRAIMERLQSREWFDADAVVISDFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: CR3L2_DANRE
Sequence: MEIMDSGEPFLQWDKNLSELSEAGENDILYSTHFTDLLDDLSQEALLGQLLSDPFLSGRGDAMDTEEELTRASPVPPHIQAEHSYSLCGDSRPQSPLSHLPGEPGSDAADSESDEWPMEQEDKGIKMEPLLCVPLPALTLTVTPAGSAPEPVIDSCDSAQSLSLPQVKEDSNSPQIKLEPHEVDQFLNLSPKGLECLQMPPTPPSSVGSDSEGSQSPVHPCAPASPTQTPAVLKVAPRAPSSLSSSPLLTAPHKLQGSGPLLLTEEEKRTLIAEGYPVPTKLPLSKAEEKALKKIRRKIKNKISAQESRRKKKEYVDALEKKVETCSNENHELRRKVENLECTNKSLLQQLHSLQAVVAGKVPRSCRVTGTQTSTCLMVVVLCFSLFLGSFYPGLSPCSSITKADLSREISIHDSYTTTVKSRSLLSIQEPGGLDEPHPIGLGGEYPEWDRQADVMAAWRFEQQHKEEEAELHKAEHRPLLLSTNETHAQKAILIDLHTHRSNETAKVIQLDRTVNETS
What is the function of this protein?
Transcription factor involved in unfolded protein response (UPR).  In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.  In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2.  The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.  Plays a critical role in chondrogenesis.  May protect neuroblastoma cells from ER stress-induced death.  In vitro activates transcription of target genes via direct binding to the CRE site.
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 2, cAMP-responsive element-binding protein 3-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element- binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus.