PharMolix/UniProtQA huggingface dataset:
Protein: RS27A_BOVIN
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK
What is the function of this protein?
Component of the 40S subunit of the ribosome.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a, Ubiquitin carboxyl extension protein 80.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
Protein: Y1088_ARCFU
Sequence: MNEITPLFDEEVIKVLVQTRNLLEEILETLDIMADKELMEAIFKSENEIRQGKTRNFKEILKELP
What are the official names of this protein?
Uncharacterized protein AF_1088.
Protein: Y7217_BURP6
Sequence: MLRYALIFFIIAIIAAVLGFGGIAAGAAEIAKILFYIFVVIFLVTLVLGVARR
What are the official names of this protein?
UPF0391 membrane protein BURPS668_A3117.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DRE2_ASHGO
Sequence: MTHSRTALVLIHPATTTRPELLTAAKQHSSLSGANIEQHLVNKLNDGSLQLQDNSYDVIFYVTPEAADEILFPRRLIGVLAAALRAGGSLHGLYDKYQVDALLSGFDIVREPTYHWQKRAVTASAPVKLAPRQPVSAAGLPRFKRASAPSPAAVTPTLDEVPPAAVDPVKAALLDSAAGDAPIAENDLVVGHDSTPITLLTCGRTQTRRRKACKDCTCGLREENEKEISDTHARQEKLLLGDAVKFSEPELAEIDFTIEGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLSAISDDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: IPPK_CRYNB
Sequence: MNDGNHYRPAISPNPSADTQPSDWAYIAEGGAHIVFSYQGRSKTYATRALRVRKPSATTEPLAQAEENDLFGQWRRNILPKLLPRQLLTTSREVILEDRWYKELLAMVDVVRPDQRKSGIDFAAKGDRRGVLLEDLTSSEDDGAIAVAIEIKPKWGFLPCTEHLHPPESVSIKSHVSRFRLHQHFRGCSDDPPYDPLDLFSGDKMRMRTALDGLWTMWEISRGKVNNWKVFVGGKEISPDDLQNGLLPIGGDDFVTKITQLTLDTLQTSFALPLLKNLQQNLDPIDISSLAALFQAEYPNSPPFDPDLIPDVSAVELNGFVDIYISDPQAGQRMDSWSLRERIIAYALSAIFKDCSLFIRGFLKHAEDGVWRLVSGSDSVKVIDLDLKPIKNIQKWAETDEKVWKYWLETKGAR
What is the function of this protein?
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
What are the official names of this protein?
Inositol-pentakisphosphate 2-kinase, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase.
What is the protein family that this protein belongs to?
Belongs to the IPK1 type 2 family.
Protein: HMN1_HUMAN
Sequence: MAPRGFSCLLLSTSEIDLPVKRRT
What is the function of this protein?
Plays a role as a neuroprotective and antiapoptotic factor.
What are the official names of this protein?
Humanin-like 1, HN1, MT-RNR2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the humanin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm.
Protein: BUDR_KLEAE
Sequence: MELRYLRYFVAVARERHFTRAAKALGISQPPLSQQIKRLEEEVGTPLFRRLTRGVELTEAGEAFYEDACKILALSDAALEKARGIARGLNGNLSIGITSSDAFHPKIFALIRQFQVQNMAVQVHQVEANMSSLTAMLAEGELD
What is the function of this protein?
Regulator of the budABC operon for 2,3-butanediol synthesis.
What are the official names of this protein?
HTH-type transcriptional regulator BudR, Bud operon transcriptional regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: AIM21_YEAS7
Sequence: MPSEVTPKVPERPSRRKTSELFPLSGSESGDIKANSEPPTPAGTPNVPTRRPILKAKTMTSFESGMDQESLPKVPLQRPVRRSTTEELNNVMNNTSKELEEIESLISKHNIHSVSRKKSPTSVQEGKAAAIHQNGQRSASDNKTSTNPSPLEKNEHKGDEGNESAISPSNSVNKSNNEVTEHSDSEDLTEKQKVHAALDNEAGDGSHFEEKLIPGDMKVPVDVSKDVEEGSLNALPPSGITESDDKAEKFTKHPESSLEELQKHQEQQEEKIFQNPTDEESTTSLNEKQEGKDNMEVNSQPQGPSDTETVIAATSSNVPSQIASEEENDVPVIPRSRPKKDFEAHVQKEELPNTQEKLVSEECDSTLISTEEESKIPKIPSERPKRRAPPPVPKKPSSRIAAFQEMLQKQQQQDLHNNGNSSATTASADIAKKHTDSSITSDTTKADFTSKLNGLFALPGMVNPGQLPPSLEKKLSSPDTESKLGTQDQSQAKTGPLGGTRRGRGPRGRKLPSKVASVEKIEEDDNTNKIEIFNNWNVSSSFSKEKILMDTTPGEQAERALDEKSKSIPEEQREQSPNKMEAALCPFELDEQEKLPANAESDPLSQLPQTNAVGNRKAISEESLSPSEAIANRDQNDTTEIQEQQMEDQMEVDMERELSGGYEDVDSALHSEEASFHSL
What is the function of this protein?
Involved in mitochondrial migration along actin filaments.
What are the official names of this protein?
Altered inheritance of mitochondria protein 21.
What is the protein family that this protein belongs to?
Belongs to the AIM21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches. Localizes at the shmoo tip.
Protein: TIG_LIMF3
Sequence: MSVKWERDSDAPKGTLTFDIDTETIQKGIDHAFTRTQKRISVPGFRKGHVPRTIFNQMYGEESLYQDALNDVLPDAYEAAIKEAGIEPVDQPQVNVESMEKGQPWTLTATVAVKPEVTLGDYKGMEVPEQDTSVSDADVDSELENKRQQQAELVLKEDEAAADGDTVVIDYEGSVDGEKFDGGSADNYSLVLGSGSFIPGFEDQLVGHKAGEDVDVNVTFPEDYHAKDLAGKDALFKVKIHEVKEKQLPELDDEFAKDVDEDVETLAELKDKVKKQLQDQKEAAAKAAIEDAAIEAAVANAETEEIPQAMLDDDTNRQLQQYLAGMQQQGINPQMYFQITNTTEDDLRKQFADDAAKRVKTNLVLEAVVKDANLNATDEDVQNEIADLAKQYGMDEEAVSKALTRDMLEHDIEIKKAVDLIADSAKQTAKAADKD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LPXK_ACISJ
Sequence: MAAPGRPSPLAERLRGAWQHRGALALALWPLSLLYGVLTALRRALYRTGLLRSERLPVPVIVVGNVIAGGAGKTPVTLAVVRHLQARGWRPGVISRGYGRATADCREVLPASSAAEVGDEPLLIARASGAPVFVARRRAQAGRALLAAHPATNILVCDDGLQHLALARDLEVCVFNDEGAGNGWLLPAGPLREPWPRAVDLVLHAGSPPGGGAPQFALSRELAAHAVNASGQHLPLEQLQGEPLHALAAIARPHDFFAMLHARGLQPESEEALPDHYDFSSWKRPPDKRLRLICTEKDAVKLWPAHPDALAVPLALRIPPAFFDTLDARLASLSSSGH
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: HPM9_HYPSB
Sequence: MFCIIRAQLLLLLHLLVLALLLVGTVCNAHPQHGHPSELEPLALKRGGSPRDDGNTLAPRCRCIPGEACWPSTQIWDSFNRTIGGSLIKTAPLAESCYPGPKKNTRKCAVVSRKWTDQDFQTDSPVGRTYPYNITCAPVNYFAGQRPTTCSLGQLPVYAIDARTRQSVAQGLRFAKDNNLRVTVVSTGHDLLGRADGYGSLEIWLRHHRNEIRFERQYMATDGCRESGWTGSAIDIDGAYQWRDVHIKARANNVIVVGGGSVSPGAIGGWPSGGGHGPASRNYGLGADQILEAEVMLADGSVVLANHCQHTDLFRALRGGGPGFGVVLKTKIKAYPNVASVSVHHLTITPIRQTPNNSDLLDAVAVLMQAYPKLSDDGYAGYAFWLRNCKSFFIGSAKSGYRHGIWMIGKTTEEAEHSFAPVREALDKFKSKLTISESYMTYNDYWSFYTSESGLYESVGTTSVLTSRLIDRPAVEDYNRVREAVEVIGGKPEDYATNVMMLVSNGQVFADAADKSSGLNPAWRVSPYVVISSRGIPMVVDQASRKEVADDITYVKGAALQKLAPNTGGYMNEGDRNDPNYIKNFFGTIYPTHLATKKKYDPWGLFYCPTCVGAELFEETSRGELCRR
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690).  The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707).  The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707).  Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707).  The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690).  The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690).  The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690).  The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690).  The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690).  The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690).  The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A.  The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
What are the official names of this protein?
FAD-linked oxidoreductase hmp9, Hypothemycin biosynthesis cluster protein hpm9.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: ABFB_ASPNG
Sequence: MFSRRNLVALGLAATVSAGPCDIYEAGDTPCVAAHSTTRALYSSFSGALYQLQRGSDDTTTTISPLTAGGVADASAQDTFCANTTCLITIIYDQSGNGNHLTQAPPGGFDGPDVDGYDNLASAIGAPVTLNGQKAYGVFMSPGTGYRNNEATGTATGDEPEGMYAVLDGTHYNDACCFDYGNAETSSTDTGAGHMEAIYLGNSTTWGYGAGDGPWIMVDMENNLFSGADEGYNSGDPSISYSFVTAAVKGGADKWAIRGGNAASGSLSTYYSGARPDYSGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDDVENSVQENIVAAKYVSGSLVSGPSFTSGEVVSLRVTTPGYTTRYIAHTDTTVNTQVVDDDSSTTLKEEASWTVVTGLANSQCFSFESVDTPGSYIRHYNFELLLNANDGTKQFHEDATFCPQAPLNGEGTSLRSWSYPTRYFRHYENVLYAASNGGVQTFDSKTSFNNDVSFEIETAFAS
What is the function of this protein?
Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysac-charides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan.
What are the official names of this protein?
Alpha-L-arabinofuranosidase B, ABF B, Arabinosidase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 54 family.
Protein: NUOD_XANOR
Sequence: MSEFRQATDAFASNPAESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRDLPDRMPRYKESRWHKGGALKKLNAAREGSMLDFLEDFTNTFPLRVDEYETLLTDNRIWKQRTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NU3M_YARLI
Sequence: MNTFIIFIILIPIVGFALLAVNILLAVYKPYNEKLGAFECGLTSFNQTRLAFNAAFILVAILFLPFDLEISTLLPYVMSIYLVSNYGFTIVLLFLLILIIGFVYEINTNALKINKHNKPNTDSLIYKL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: SH3R2_MOUSE
Sequence: MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGQSSWKGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLVPSVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLRRQLDENWYQGEINGVSGIFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVEPNVSARHLLENKGHQLSRTRHLSLMSSPSRGKATNTSSLRKSPGSRRKGSGQFSMTTALNTLNRTVHSPEGHQMVEISTPMLISSNSPSVLTQHGDKADFPTSSTGQVSSSQPAPASPGHSTAMVSVPSSQQHLSNNMFVALHTYSAHRPEELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDYVIPVFSSTARKTSSFPDSRSPTVCTTWALSTSSVSSQGSFAEGDPRQSGPFKSVFVPTAVVNPSRSTPGPGSSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPTMVIRPQRFQFYPPQGMTPSPTPIMVEMGSKSIYTGEPALTCINRGSKTRIHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKNGTEKQVKTVRFQNYSPPPTKHSASSPTSGKHDHPATLKGSQHEAVSSGGEMTILFAHRSGCHSGQQTDLRRKSAFGKTMPLLSTASATQTLFPSK
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.  Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation.  Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation.  Inhibits PPP1CA phosphatase activity (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase SH3RF2, Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, RING-type E3 ubiquitin transferase SH3RF2, SH3 domain-containing RING finger protein 2.
What is the protein family that this protein belongs to?
Belongs to the SH3RF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DVL8_ARATH
Sequence: MSRLRNSAQLQLSKKESLGDNGGALNTTRSSRQKQGKYGFTRKCGRLVKEQRARFYIMRRCVVMLICWTDHNNNNSDHS
What is the function of this protein?
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
What are the official names of this protein?
Small polypeptide DEVIL 8, Small polypeptide ROTUNDIFOLIA LIKE 7, Small polypeptide ROT-FOUR-LIKE 7.
What is the protein family that this protein belongs to?
Belongs to the DVL/RTFL small polypeptides family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS5_STAAE
Sequence: MARREEETKEFEERVVTINRVAKVVKGGRRFRFTALVVVGDKNGRVGFGTGKAQEVPEAIKKAVEAAKKDLVVVPRVEGTTPHTITGRYGSGSVFMKPAAPGTGVIAGGPVRAVLELAGITDILSKSLGSNTPINMVRATIDGLQNLKNAEDVAKLRGKTVEE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TRMN6_SHESA
Sequence: MAFTFKQFHIDDLNCGMPVSTDGVILGAWAPLSRAKHILDIGAGSGLLSLMAAQRSQGQITAVELEEKAAAACQYNMTQSPWADRCKLIHGDIQHVCQQAEYQEYFDHIICNPPYFEHGPKANEQHRAMARHTDTLGFTPLLEAISQCLSHEGHASLILPIQSLTRFKACLHQTQLYLVKEVRVKSMENKDANRVLLLLAKILLTQSQDEPCQHTELTLRGEDGRYTEQMIALTKDFYLKL
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KR222_HUMAN
Sequence: MCYYHNYYGSLDYGCSYGSEYGNSGYACNFPCSYGRFLLAPRKKF
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
What are the official names of this protein?
Keratin-associated protein 22-2.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 20 family.
Protein: VM2EA_ECHCS
Sequence: IGIAYNRGMCDPKKSVGTVMDHSTEHLSVAVAMAHEMGHNLGMDHDGNQCNCGGAGCVMSEELIESRSYKFSDCSKNQYQNYLTIYKPQCILNQPLRTDTVSTPVSGNELLQNSANPCYDPLTCHPREGEQCESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPATAKGSVLM
What is the function of this protein?
Potent inhibitor of ligand binding to the integrins alpha-V/beta-3 (ITGAV/ITGB3) (IC(50)=20. 7 nM), alpha-IIb/beta-3 (ITGA2B/ITGB3) (IC(50)=51. 5 nM), alpha-5/beta-1 (ITGA5/ITGB1) (IC(50)=132. 6 nM), and moderate inhibitor of ligand binding to the integrin alpha-V/beta-5 (ITGAV/ITGB5) (IC(50)=286. 4 nM) (PubMed:9269775, PubMed:33182321).  Competition with fibrinogen for the RGD recognition sites on the alpha-IIb/beta-3 integrin (glyco-protein IIb/IIIa complex) results in the inhibition of platelet aggregation and other antithrombotic properties such as an ability to prevent coronary thrombosis in animal models (PubMed:3198653, PubMed:2320569) (Probable).  Is also a potent inhibitor of bone resorption.  This results from the blocking of the interaction of alpha-V/beta-3 integrin on the surface of osteoclasts with bone extracellular matrix (Probable).  In addition, interaction with alpha-V/beta-3 also inhibits human umbilical vein endothelial cells (HUVEC) proliferation (IC(50)=103. 2 nM) and inhibits the migration of some tumor cells (IC(50)=1. 5-154. 5 nM), suggesting that this disintegrin could be a good scaffold to design potent antiangiogenic agents by modifying its unique C-terminal tail structure (Probable) (PubMed:33182321).
What are the official names of this protein?
Disintegrin metalloproteinase/disintegrin echistatin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MYZAP_RAT
Sequence: MLRSTSTVTLLSGGSAKSPGTPSRRANVCRLRLTVPPENPVPQQKEKKIERKDQPPELSNGESTKKLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNSALALDSVGLQKTLVDVTLENSNIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADFDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSTTGRTREIAVPSRSYTPYTRVLELTSKKTLT
What is the function of this protein?
Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF.  Targets TJP1 to cell junctions (By similarity).  In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1.
What are the official names of this protein?
Myocardial zonula adherens protein.
What is the protein family that this protein belongs to?
Belongs to the MYZAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disKs. Colocalizes with F-actin. Colocalizes with cortical actin (PubMed:20093627). In neurons, colocalizes with GRIN1 in postsynaptic neurites (PubMed:18849881). In heart, localizes at area composita, the mixed-type junctional structure composed of both desmosomal and adherens junctional proteins (PubMed:31384490).
Protein: Y2036_BORPE
Sequence: MKKNPSSPAGCPCGKPRAYPDCCGRWHAGALFLQAPDAESLMRSRYSAFVLDQLDYLLQTWHPDTRPSELEPNAADVKWLGLQIKASQQQDDTHATVEFVARLRQAGRATRLHELSRFVKEEQRWYYVDGDIR
What are the official names of this protein?
UPF0225 protein BP2036.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: TPIS_METBR
Sequence: MNEIKETPIVILNFKTYLESTGENALKLAKGSEMVAEETGVNIMVHPQYADIYRIAHEVNIPVLAQHIDTIDAGGHTGSILPECVKEAGAVGTLINHSERRVELFEIDAAIKKADSLGLSTVVCTNNIETSSAAATLNPDFVAIEPPELIGSGIPVSKPEPEIVEKTVESIHNINPEVRVLCGAGISTGDDLKAAIDLGSEGVLLASGIILADDPKKALLDLVSKI
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1087_RICFE
Sequence: MKRIIKKDQSSVINYINDQKLLHLAIRAGYKNIVEYLLKKGANPNIQNNNGETTLHFAAMNGCVRTIECLIKSGAIIDSFDKFERTPLELAINSGNTDAVKLFLQYEATIGNTLNQYLNILVKN
What are the official names of this protein?
Putative ankyrin repeat protein RF_1087.
Protein: TTCA_BURPS
Sequence: MNAPHTPHLNEAEAAAAVEANAAELGRRALTRREQKEAYENNKLFKRLVRQVGQAIGDYNMIEHGDKVMVCLSGGKDSYALLDILLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLTKIGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYAKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIRDWDKRFPGRVDNMFNALANVVPSHLMDARLFPFAGLRATGEADPNGDIAFDEDPCGTDASAPGGAKSVSIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.