PharMolix/UniProtQA huggingface dataset:
Protein: NUOH_RICRS
Sequence: MLELFFEYIFPLIIIALKVVAITIPLILCVAYLTYAERRVIGLMQLRRGPNVVGPFGLLQPIADAVKLLFKEPIIPTNADKILFILAPMITFILSLIGWAVIPFAKGVVLADINVGVLYILAISSLSVYGIIIAGWASNSKYAFLGAIRSSAQMISYEVSMGLVIITVLLTTGTLNLSEIIEAQRTIPWWIDLMLLPMGVVFFISVLAETNRLPFDLPEAESELVAGYNVEYSSMGFALFFLGEYANMILVSAMTTTFFLGGYLPPFNISWLDCIPGFFWFVFKVGFLLFCFLWIRATLPRYRYDQLMRLGWKVFLPLTLFWVVLVSSVLVYTDNLPSI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MCH_METMA
Sequence: MISVNEMGSYVIEEMLDWSEDLKTEVIKLENGATIIDCGIKAEGGYEAGMYLARLCLADLADLKYSTFDLNGIKWPAIQVATDNPVIACMASQYAGWRISVGNYFGMGSGPARALGLKPKELYEEIGYEDDFEAAVLVMESDKLPDEKVVEYIAKHCSVDPENVMIAVAPTASIAGSVQISARVVETGIHKFESIGFDINCIKSGYGIAPIAPIVGNDVQCMGSTNDCVIYCGETNYTVSFEGELAKLEDFVRKVPSTTSDDFGKPFYQTFKAANFDFFKVDAGMFAPARVTVNDLKNKKTISSGGLYPEILLESFGIRKV
What is the function of this protein?
Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCM1_LAMGL
Sequence: SLVSLNEPKDEIYMESQP
What are the official names of this protein?
Glycosylation-dependent cell adhesion molecule 1, GlyCAM-1, Lactophorin, Whey protein.
What is the protein family that this protein belongs to?
Belongs to the PP3/GlyCAM-1 family.
Protein: VPB40_MYCTU
Sequence: MRTTIDVAGRLVIPKRIRERLGLRGNDQVEITERDGRIEIEPAPTGVELVREGSVLVARPERPLPPLTDEIVRETLDRTRR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin is VapC40.  Upon expression in E. coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9.
What are the official names of this protein?
Antitoxin VapB40.
What is the protein family that this protein belongs to?
Belongs to the VapB family.
Protein: RSXD_SALPK
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLIAALPGIAAQTWFFGWGTLFQIVLAAITALVAEAIVLRLRKQSVASHLQDYSALLTGLLLAVSIPPLAPWWIVVLGTGFAIIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPYEIAATTPDILDTLRMIFSGHTASGGDMTLLRTGIDGISQATPLDTFKTSLRAGHSVEQIMQYPIYSGALAGVGWQWVNLAWLVGGVFLLWQKAIRWHIPVSFLLTLALCAALGWLFSPATLASPQLHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGVLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MANA_PIRSP
Sequence: MKSLNVILTLLSLIISVLSKKVYYEAEDGKLNGITVFKELSGFSGKGYVGRFENPGNSVTVTVDAPATGMYDLSIIYCANMGQKINSLTVNDQSVGDITFTENTKFETKDVGAVYLNKGKNTIGLVSSWGWMWVDAFVINDAPNAAKDVSSKLNPTLVNPKAIPAAKKLYDFLKTNYGKRILSGQVGAAGQAGDEGQEIQRIQKATGKLPAVWNMDFIFESNDCTWRPQNPDITEMAINWWKKYEGKGIMAAQWHWNIAGKTGDFAFYSKDTTFNLENAVTEGTWEYEKIIKDIDRVSGHIKKLQAVNMPLIWRPLHENNGDWFWWGNNPKACAKLWKILYERMVNYHGLNNLIWLWNGNNDANTPVDYIDIIGVDIYANDHGPQTTAYNTHFDFYGGKKMVVLSENGRIPDIQQCVDQDVWWGYFQTWNSEFILQDSYHTDAQLKEYFNHKTVMNMDELPSFNVDSYNGDSGSSHNGNSESNSNTGNSDECWSINLGYPCCIGDYVVTTDENGDWGVENNEWCGIVHKSCWSEPLGYPCCVGNTVISADESGDWGVENNEWCGIVHKSCWAEFLGYPCCVGNTVISTDEFGDWGVENDDWCGILN
What is the function of this protein?
Hydrolyzes 1,4-beta linked polysaccharide backbones of mannans, one of the major hemicellulose components in hardwoods and softwoods.  Shows very high activity against mannohexaose but not against mannopentaose and smaller mannooligosaccharides.  The major products released from mannooligosaccharide hydrolysis are mannose and mannobiose.  The reiterated 40 AA domain is involved in binding the cellulase-hemicellulase complex.
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase A, 1,4-beta-D-mannan mannanohydrolase A, Beta-mannanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 26 family.
Protein: SOMA_BALBO
Sequence: FPAMPLSSLFANAVLRAQHLHELAADTYKEFERAYIPEGQRYFLQNAQSTGCFSEVIPTPANKDEAQQRSDVELLRFSLLLIQSWLGPVQFLEKAYANELVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUN18_ORYSJ
Sequence: MANCVRCCCWLLVLMLMALAITAAVVFVRYKNGEGVFPFPGVPGAVDHKYADALAVALQFFQVQKSGKLVNNTIHWRGDSALDDGKEAGIDLSKGMYDAGDHMKFGFPMAFTATMLSWSVLEYGDAMRAADQRDSAIDALNWIMDYLVNAHPSDDVLYIQVGDPKADHKCWERPEKMKEKRPLTKITPKSPGSDVAAETAAAMAAASLVYKTINKTYSSSLLDHGERLFAFADKHRGSYTRTFPELSAFYNSTTYQDELLWAASWLYHATGNHSYLAYATGKNKDFADLGNPRYFSWDDKRAGTEVLLSRVSFFASQGSDVAQDDVLGMYKQTADAVMCILLPDSETAAFRTEGGLLYVAEWNSLQHPVASAFLAAVYSDYMQSSGKTELSCSGQGFSPADLRKFAKSQADYLLGSNPMKISYLVGYGDRYPEKVHHRGASIPEDVDTGCDGHKWLETSKPNPNVATGALVGGPYKNDSFVDERDNVMQNEATTYNSALVAGLLSALVSTSSLARSLS
What are the official names of this protein?
Endoglucanase 18, Endo-1,4-beta glucanase 18.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RS3_HAPAX
Sequence: MGQKVNPIGFRVGVIRDWDSKWYADKKIVPALVKEDAVIRKFLNKKYNNAAVSHVEIERLKELKVKKRVKITLHSGKPGVVIGREAATMKETIASLEKLTKKEIVFNVVEVRKPEVVATLVAQSMAEQLENRASFRKSTKNCYAKSIKVRAKGIKTLSQRLGGREMARTEGYSEGQVPLHTLRADVEYATAEAQTTYGILGIKVWIYHGEILPGQSHEELRKERQSSASSNHGGGKRRPSRKGPRRSQEDAATEGGN
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: OPGD_CROS8
Sequence: MNRRRFIKASLALAAACGTPGLATLFSRNAWAQESDIADGQTRAFDFSVLQAMASELAQKPWGGAPRPLPDTLAKLTPQAYNSIQYDAGHSLWNNIEGRQLDVQFFHVGMGFRRRVRMFSLDPATRQAREVHFRPELFNYHDAGVDTRQLEGQTDLGFAGFRAFKAPELARRDIVSFLGASYFRAVDSTFQYGLSARGLAVDTFTDTPEEFPDFTAFWFETPKAQDTTFVAYALLDSPSVTGAYKFIIHCESSQVIMEVENFLFARKDIKQLGIAPMTSMFSCGTNERRMCDTIHPQIHDSDRLAMWRGNGEWVCRPLNNPQRLQFNAFSDENPKGFGLLQTDHKFESYQDVMGWYNKRPSLWVEPRNRWGKGTVALMEIPTTGETLDNIVCFWQPEKPIRAGDKLNFQYRLYWSGDAPVRTPLARVYATRTGMGSFPEGWAPGENFPTQWSRRVAVDFVGGDLKGAAPRGIEPVITLSSGEAKQVEILYVEPFDGYRIQFDWYPTSDSVDPVEMRMFLRCQGEAISETWLWQYFPPAPDKRKYVDDRQMR
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VGRGB_DICD3
Sequence: MANSTGLQFTVKVGALPDTTFAVVDFELSEALNQPFALSLNLASSQPGIDFGAVLDQPCELLVWYEGELQRRVSGIVSRFAQGDTGFRRTRYQAEVRPALWRLGLRTNARIFQTQKPDAIISTLLEEAGITDYAFALRHDHAVREYCVQYRESDLAFINRLAAEEGLFYFHEFEAGKHRVVFADDAGALAKGPELFFNLATQGLSEGAYVRRFRYAEAVSTAEVALKDYSFKTPAYGLLHNKMSSELAHQRESYQHFDYPGRFKQDPSGKAFTGYRLDALRAGAMTGNGESNAAELRPGSSFTLTEHPNPAFNLAWQVVAVAHSGQQPQALEEESGGEPTTLSNSFEVVKATTTWRAALPYKPMVDGPQIATVVGPAGEEIYCDEFGRVKLQFPWDRYGASDDQSSCWVRVSQGWAGGQYGLIAIPRIGHEVVVSFLEGDPDQPIVTGRTFHATNPSPYPLPASKTRTSLRTSTHKGAGFNELRFEDQAGQEEVFIHAQKDMNTVVLNNRSTSVNASHTENVGGDQTVVVQHNQTVSVKENQVTEIQGEQTVAVTKNRHTTVDDNESLQVKKNIAIQSQSGDVLIATAGGFIAIDKDGNISITGKGLVLNGTRIDLN
What is the function of this protein?
A Vgr protein that is probably part of a type VI secretion system (T6SS).  May be required for export of proteins involved in Rhs-mediated cellular contact-dependent growth inhibition (CDI).
What are the official names of this protein?
Putative type VI secretion system protein VgrGB.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
Protein: NFUA_ACIBY
Sequence: MSTENTNTAVAEEIPNLLITPSAQEYLHELLAKQNTPGIGVRIFVEHPGTPRAECCMAYSAPEEVVPTDYKQDYPDFPAYIDAPSIPYLLDAVIDYNKDRFGGQLTFRAPNSKVPRVGPDASIEERITYVLQAEINPGLAGHGGNCSLVEVQDDPEHGLTAVLKFGGGCQGCSAIDVTLKQGVETTLKEHIPELQRVVDQTDHTQAEGAYFK
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: PHNC_BACCR
Sequence: MIEFRNVSKVYPNGTKGLNNINLKIQKGEFVIMVGLSGAGKSTLLKSVNRLHEITEGEIMIECESITAAKGKDLRRMRRDIGMIFQSFNLVKRSTVLKNVLAGRVGYHSTLRTTLGLFPKEDVELAFQALKRVNILEKAYARADELSGGQQQRVSIARALAQEAKIILADEPVASLDPLTTKQVLDDLKKINEDFGITTIVNLHSIALARQYATRIIGLHAGEIVFDGLVEAATDEKFAEIYGDVAQKSELLEVAAK
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SECG_PYRNV
Sequence: MARRRRYEGLNPFVAAGLIKFSEEGELERIKLTPKSAVVISVALIAAILVLNLIHPL
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: LRGA_STAA1
Sequence: MKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKIKIEEAQAHD
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PALA_CRYNB
Sequence: MSNFLPIPTKAATPLPSFAKHLLDYISAHFRDTHSEAFRKDVDVLVGMRKDWVEAKLEAHPEIIRAFMRYHAQLAFLSTKFPSDINLPFAYYLPFPATFSLSPDAPISLSSLTFERACVLFNMTALYASMAAAERRAEAEGIKRALGYLTAAAGVLEYLITSVLPTLRSELSSPQAAGYDMTESFLGTLKEFVLAEAQECYWQQAVLQGTYKNGLIGKLSMKVSEYYKAALASMNGTDYPSSSYFPLNWTAHMNVKQMHFEAAAQFRLSQEDLEKSRYGEEIGRLKVAESLAKKGLDAARKGVADSVVSDLKQLHAAIKSSLERAVRDNDLVYVQPIPPANQLAPIVGVGMVKVNVPAEVAEPVAWLMGGKAGMEPLFSGLVPYGVHLALSIYDDRKDTLVRDLDGKREELDGLAASTLQSLNLPGSIQALDRPVGLPPSLLKKSEEVASSGGIERIRSLLDEVNRLAHANVQSLNEAMDILDQEATENESLIARQPELQQTRQPSHVANQPLIQMAEQYEATIKQAGGSDATVRAKWEEWARLVGILAAGEMEMEDYVPGTTSPSGSLPPSVRPLRASLEELDDRIAHRARLVREARQISAADDIRPEVLKEAAKLAHGGSGDVKTEWFEDLFEKGLEKYMGVKREMDEEVAKHDELLEQIRTQNESFLSERKDDPIIKERERRLQDMDLAYWKWREIVDNAEEGIKFYNSFAEMLHGFKAACGQFLNTRRIDVGQMTTQFQQQMNVSEPQQQPEPRYQSPSPQSFQPSFSPSPSHFQPSAPSSFSSSPVRSPAPSAPARRESPPKTLSFLPHPSSSAWQPASVDFLPPPPPPPILRSGGIQSQPKVAPPVTPSITAIRDQTQGTPRRMTRAAAAAAERDEATERNKYSSGGPRRKGGGVV
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.  May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
What are the official names of this protein?
pH-response regulator protein palA/RIM20.
What is the protein family that this protein belongs to?
Belongs to the palA/RIM20 family.
Protein: DEGP_SALTY
Sequence: MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDSPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPRSDIALIQIQNPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVMPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEGAEMSNKGQDKGVVVSSVKANSPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ
What is the function of this protein?
DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures.  It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions.  DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids.  Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins.  Its proteolytic activity is essential for the survival of cells at elevated temperatures.  It can degrade IciA, ada, casein, globin and PapA.  DegP shares specificity with DegQ.  DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP) (By similarity).
What are the official names of this protein?
Periplasmic serine endoprotease DegP, Heat shock protein DegP, Protease Do.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TALDO_CAPAA
Sequence: GVTSNPAIFQKAISTSNAYNDQFR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_STRPN
Sequence: MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLASLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGPAEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVGTLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEHLDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLTEKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TA2R4_PANTR
Sequence: MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNXERSVYLSAFFVLCFMFLDSSSLWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNINEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).  In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 4, T2R4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Protein: CYB_INIGE
Sequence: MTNIRKTHPLMKILNNALIDLPTPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTPDTLTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLYIHIGRGLYYGSHTSQETWNIGVLLLLMVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWVWGGFSIDKATLTRFFALHFILPFIITALVTVHLLFLHETGSNNPTGIPSNMEKIPFHPYYTIKDILGALLLVSVLLTLTLFAPDLLGDPDNYTPANPLNTPTHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILIFIPMLQTAKQRSMMFRPLSQLLFWILLTDLLTLTWIGGQPVEHPYIIMGQLASILYFLLILVLMPIASLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRPC_POLNS
Sequence: MSNILNKIVATKKIEVANRLKQVSLANQRAQAEANNQDVLLKPRGFIQAIEKKITAGKAAVITEIKKASPSRGILRELFVPTDIAQSYEKHGAACLSVLTDADYFQGCNDYLQQARAACSIPVLRKDFTIDPYQVYEARAIGADAILLIVAYLELNQMKDLEACANELGLDVLVEVHNASELEQALELKTPLLGINNRNLKTFEVTLQNTLSLLSMVPNDKTLVTESGILSHTDVQLMRDHHVNAFLVGEAFMRAADPGAALSELFS
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RUVB_SHIB3
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIIIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MUKB_ECOLC
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.