PharMolix/UniProtQA huggingface dataset:
Protein: IL2_PIG
Sequence: MYKMQLLCCIALTLALMANGAPTSSSTKNTKKQLEPLLLDLQLLLKEVKNYENADLSRMLTFKFYMPKQATELKHLQCLVEELKALEGVLNLGQSKNSDSANIKESMNNINVTVLELKGSETSFKCEYDDETVTAVEFLNKWITFCQSIYSTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GALR3_HUMAN
Sequence: MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
What is the function of this protein?
Receptor for the hormone galanin (PubMed:25691535).  Receptor for the hormone spexin-1 (PubMed:24517231).
What are the official names of this protein?
Galanin receptor type 3, GAL3-R, GALR-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCYL3_HUMAN
Sequence: MACAVFQIPPWHLDRKYGSCSTILLDNSTASQPDLRHTLERYANRSLAIFEEPVHPLPQEKLPGKSFKHDPKRNCIFRHFCTLFQVIKLTAPCAIVALVYIKRLLTSANIDLCPTNWKKIVLGTMLLASKVWRNHGLWSVDDSQNSKDTAVENMSKMEKCFLELLEFNIHVSASVYAKYYFDLCALANDHDLYFLFSFLHKDKAQKLEGHTSQHSLSLGPCRVGMENYATYSPLSSQPVLGALSLAEVLPQEIKQEIHQVLMDHGVPCHYTCFLLHPEDSTLERFLVLHSIQGLQEDSVLCKVEIHGLSPQPQTYQSHFRSPSLAELLNRISGTCRNHFAGMQK
What are the official names of this protein?
Putative cyclin-Y-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin Y subfamily.
Protein: PYREL_METST
Sequence: MKNKLIEKATELRNKGLTTGEIADELNISKDTTQWLIMQMTTVNKTKQKQKPDDFAINWKTIGSSSSRMQYIASALSDMAVEEGVVDAVVGISISGVPFATIMAEILDAELAVFHPIKHMKNESAQGALSHNFANIKNKTVVIVDDVITSGATITDAIRVCKKNGANPLVVTVLVDKKGLDDSDNVPIKSLIKINKVG
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: ANMK_ECOHS
Sequence: MKSGRFIGVMSGTSLDGVDVVLATIDEHRVAQLASLSWPIPVSLKQAVLDICQGQQLTLSQFGQLDTQLGRLFADAVNALLKEQNLQARDIVAIGCHGQTVWHEPTGVAPHTLQIGDNNQIVARTGITVVGDFRRRDIALGGQGAPLVPAFHHALLAHPTERRMVLNIGGIANLSLLIPGQPVGGYDTGPGNMLMDAWIWRQAGKPYDKDAEWARAGKVILPLLQNMLSDPYFSQPAPKSTGREYFNYGWLERHLRHFPGVDPRDVQATLAELTAVTISEQVLLSGGCERLMVCGGGSRNPLLMARLAALLPGTEVTTTDAVGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGASQETVLGAIFPANP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RL25_BURM1
Sequence: MKVVAFERKEQGTGASRRLRNAGKTTGIVYGGEAAPQMIELDHNALWHALKKEAFHSSILDLEVAGQSQQVLLRDVQYHPFKQLVLHVDFQRVDAKKKLHTKVPLHFLNAEVSPAVKLSSAIVSHVATEIEVECLPAALPEFLEVDLSKIEAGQSIHAKDIALPKGVALTAHVDAENPVIASATIPAGAVSDAAEGETPAA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: FXA4A_XENLA
Sequence: MLNRVKLEIKDPMDWNTMYQENEMYSGIHNMTNVLPSNSFLPNDVSTVTTSMPYMSNGLPGPVTSIQGNIGSLGSMPQGMVGSLAPPPSTAAYPLGYCQGESEFQRDPRTYRRNYSHAKPPYSYISLITMAIQQAPNKMMTLNEIYQWIIDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPEKPGKGSYWTLHPESGNMFENGCYLRRQKRFKCERSKSGEGEKKVNKPGEETGGNLKENPVGYDDCSSSRSPQAAVNDGGRDSTGSSIHQACGSSPVGLSPTSEQAGTASQLMYPLGLSNDGYLGLVGEDVHLKHDPFSGRHPFSITQLMSSEQDQTYANKMEMCPTTDHLVHYSNYSSDYHNMASKNGLDMQTSSSTDNGYYANMYSRPILSSL
What is the function of this protein?
Transcriptional repressor involved in embryonic nervous system development.  Plays a role in the induction and patterning of the anterior-posterior neural axis.  Involved in the establishment of floor plate differentiation from neural plate cells during gastrulation.  Binds the anf1 promoter sequence to restrict expression of anf1 to the anterior of the neural plate, thereby patterning the forebrain.  Can bind to the HNF-3-alpha DNA target sequence.  Cooperates with t/bra in a dose-dependent manner to specify dorsal mesoderm formation, including notochord.  Binds to DNA via the target sequence 5'-[GA]TAAA[TC]A-3', with 5'-GTAAATA-3' being the preferred binding site.
What are the official names of this protein?
Forkhead box protein A4-A, FoxA4-A, FoxA4a, Fork head domain-related protein 1, xFD-1, Protein pintallavis.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROL_ECOLC
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1A_METJA
Sequence: MAKQKPVLNVAFIGHVDAGKSTTVGRLLYDSGAIDPQLLEKLKREAQERGKAGFEFAYVMDNLKEERERGVTIDVAHKKFETQKYEVTIVDCPGHRDFIKNMITGASQADAAVLVVDVNDAKTGIQPQTREHMFLARTLGIKQIAVAINKMDTVNYSQEEYEKMKKMLSEQLLKVLGYNPDQIDFIPTASLKGDNVVKRSENMPWYKGPTLVEALDKFQPPEKPTNLPLRIPIQDVYSITGVGTVPVGRVETGILRPGDKVVFEPAGVSGEVKSIEMHHEQIPQAEPGDNIGFNVRGVSKKDIKRGDVCGHPDNPPTVAEEFTAQIVVLQHPTAITVGYTPVFHAHTAQVACTFIELLKKLDPRTGQVIEENPQFLKTGDAAIVKIKPTKPMVIENVREIPQLGRFAIRDMGMTIAAGMAIDVKAKNK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_HELAH
Sequence: MLKIKLEKSAFENAKAECSLVFIVNKDFNHAWVKNKKLLETFRYEGEDSFLDQENKILYVGVKEDNVHLLRESACSAIRTLKKLAFKSVKVGVYTCHTHSKDNALLENLKALFLGLKLGMYEYDTFKSNKKESVLKEAIIALELHKPCEETCANSLEKSAKEALKYADVMTESLNITKNLVNTPPMIGTPIYMAEVAQKVAKEGNLEIHVYDEKFLEEKKMNAFLAVNKASLGVNPPRLIHLIYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALSNLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNVSASRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2052_ACIAD
Sequence: MAGHSKWANTKHRKAKQDASRAKVFTKYIREIVTAAKLGGADAASNPRLRAVVEKALSVNMTRDAINRAIQRGAGGEDNDDLNEVTYEGYGVGGVAVLVETMTDNLNRTVPDVRHCFSKTNGNLGTNGSVSYLFTKRGEISFEDVSLEDKIMDVALEAGADDIEIEEDGILVITSPESFGDVQDALTAAGLKSDNAEVVMSPSTKAEITDIEQAKQIMKMIDMLEDLDDVQNVYTNVEFSEEVLAQLDA
What are the official names of this protein?
Probable transcriptional regulatory protein ACIAD2052.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXH_SHIF8
Sequence: MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQMLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TAC_TERAN
Sequence: MNLKVLFLLAMVLVTLCLGEDRVTDRRQLCKCCAKLCHEDRDRTIPCSGGNSQFCEFCKRTKQKIRKDCNTQNEAKALCVGYFTGEC
What are the official names of this protein?
Tan_10cys.
What is the protein family that this protein belongs to?
Belongs to the teretoxin C (TC) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NNRE_LEGPH
Sequence: MDYYFTKGKPQLVNMKTPVYLVTQFQQLMDLMQNQYQVSCLELMQRSGKAACDFLVYRWPKVKKISIFCGRGDNGGQGYVLAQQAKKMGMIPTVWQVGHQMSMSKPPQMHEEVWYEMNSCHQQGILLHTYSPDIDLGDPELIVDALFGVGLYGHVRPEIASLLQRLQQFTVPILAIEVPTGINASTGEIAGNALAATATITFLCMKLGLLINDGKIYSGEIAFDDLLAPEAIYQQVKGIEKSSLLDSSTCFSKKIWYRNKTQKGWQLSIN
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: VMS1_CAEEL
Sequence: MGFTLKSLEFLQGVEPFRIDENHENEGASEEEEVLISAETDAGMSLMLEWKMRLSEDSDQCTTCNCPVDFGDRAVLLEHYQSLFHRTNTLRKARNMTVYTEEDFEGIENSENDLTSSQTTIGLESDDEEFDALLLPANRSFFIKNGSVFSVPRNILHVGERDVSSVTFLRPFDCAIFLWNGGHFAAAMFENDKMTVQKSFHRYVARAKQGGVQSQHDSGGKGAAKSAGAQLRRYNEQKMKEEIQSIMSSWKSRLQKTPLLFIRCAAYHRNIFFEADAGIETRDDRIRTIPFETKRPNIDEISDCWQRLQQVSEHGAESDFRAEMLEVREKRKKLARKVAGKKRKDGGMQMICEWSDDDENEDISKEKKTHHIKVRTIKKPEETVVQWPRLDDEWRQKTYNYVRQDSVEALKEHLASLNEDVTSEANDYLRNAKIPPNRSTFLHVSAANDARKCLKYFLEEVNCDSSTKDGAGLPPYSSSANSDVKSIFIDYRVKNETAGNWARTHIPEPKKKVELTEEQEREQAERKKEKKARQKEKEKLKKEIAKRDVEEMEERQKYVNMSEREKRALAVDRRLAGLPPILRCHQCGVQLPPTPFQYSHYNFCSTSCVAEHRKANPQ
What is the function of this protein?
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.  Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD) (By similarity).  Dispensable for viability and growth but is required for protection against oxidative stress and for wild-type life span.
What are the official names of this protein?
Protein vms-1.
What is the protein family that this protein belongs to?
Belongs to the ANKZF1/VMS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=translocates from the cytosol to mitochondria upon exposure to hydrogen peroxide.
Protein: PSAL_SYNEL
Sequence: MAEELVKPYNGDPFVGHLSTPISDSGLVKTFIGNLPAYRQGLSPILPGLEVGMAHGYFLIGPWVKLGPLRDSDVANLGGLISGIALILVATACLAAYGLVSFQKGGSSSDPLKTSEGWSQFTAGFFVGAMGSAFVAFFLLENFLLSMAS
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: Y093_RICFE
Sequence: MNKNIFITLLISSLLLLSGCTGDTCIDPDDFGFIKFNVSSRYNPEEITSRQEGDQVAPWRDSAYKVNGYPLTVMVRPWSYILGDKNTSGQLSAWCPWYGQKNNTTTLAAFCVKLQPCTFWDNARLDMCTPNPANQNDAMISNPPCIMTDGVGLYFLIAAKNTDPNISPDSQRKPQGITQHLGELTSSVGYEFYSISSTGQFLPAGGINYQYKGEDKSKYAQSPLYFKIIDKFYDDNSGQYRLVIKSGVTDTRPDPLQFLTDLIKGVLFGKDGIIKKTYQQIIDTPGYRMSVSAILTLYIMFTGFSFLIGNINLTHVELIVRILKVSIVSILLSTDKAWTFFHDYLFVFFIDGVQQILQIINEAAATGPGSQSLLGLLISPQTLSKLFSLLFVDWLGFIYIILYLIALYFIFFLIFKATIIYLTALITIGMIIIMGPIFICFMLFNITRSLFENWLRQLISYALQPIILFAGIAFISMIIRTEIYSTLGFGVCKHDFPNLGPINEIFGSFLEDIDPSLGNSIFYWWFPVPMKGGINNFHKAKILVPEDHIIVDDSCKNDPDKCKHCAAYECIDERYIELPFLDLVKDAKRISNFINGKFVQLDGILLIFVSIYLLSKFNDTAISTAQFIAGTSGNLTDIQKVNQQSYESAAKQMNRPLSYVAKTVSVPVTTRVSAKLEETSMFFAKGFEDIMMGRLEKQALGSSANKAVQNEVKRKYGIDSKDVKMNAITDYENGISGLLKNLPKGNELKAKELSQMKFTQLRDKIAANKYGVKDYAALSEEQKRELDKSLKDANLRELASDANFTKDYQDAYKYAHQEMSGRGVGLFGKNIKPLRSWQEMEHRVDTKRKLKEERRVGIGEKLYAGYTGIKRGALTAIVGKDLRDAYEGNLTSAEWHDFEYNDPRLRTYSEKLKDDEKAREREELQMHINKETLAAQADILSPEYLARLEKAGRQSDVEYYQELAQRKLIHEVRGRLFEEGEPVMMGDRFMREKATDSQMRDMIDNAHRKHAEFIEGDRYTRRQEHYDIMHEKAEGNLEQTYKELKDHFKRDDINIEEMPALIAQKIKDTEQGPEVDAKITEELNNFNADVKNYEYSTEVLNKIEDRKQAITDEVNAQIDQINKYRENAKMEKYVRPIVNEGRKLRKLEDHLRGMK
What are the official names of this protein?
Uncharacterized lipoprotein RF_0093.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
Protein: COAE_MYCPA
Sequence: MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLADGSLDRPALAAKAFADDAARQTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGMAPLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQASDEQRRAVADIWLDNSGSPAELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRALRVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPDARSTVERYDHTGDPALWHKRIHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDARADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWADSTGWKP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPF0157 (GrpB) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BO8_BOMOR
Sequence: MKCFAQIVVLLLVIAFSHGAVITGACDRDVQCGSGTCCAASAWSRNIRFCVPLGNSGEECHPASHKVPYDGKRLSSLCPCKSGLTCSKSGAKFQCS
What is the function of this protein?
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia.  Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons.  At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the pro-inflammatory cytokines IL-1 and IL-12.  In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
What are the official names of this protein?
Prokineticin Bo8.
What is the protein family that this protein belongs to?
Belongs to the AVIT (prokineticin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRC_HALH5
Sequence: MKTLIKNGSIVTKEGTVKTQDVLLHDGVISAIGLNLEETDAHVIEANGKLVTPGLVDLHVHLREPGGEAKETIETGTKAAAKGGFTTVAAMPNTRPVPDSAEQMSWLTGRIDETGVVRVLPYAAITTRQLGRELTDFAKLKEAGAFAFTDDGVGVQSAAMMLEAMKEAAKLEMAIVAHCEENTLIQNGSVHEGVFSKKHGIAGIPSVCESVHIARDVLLAEAAGVHYHVCHISTKESVRVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDAHYKMNPPLRGKEDREALIEGLLDGTIDFIATDHAPHTEEEKGQGMERAPFGIVGLETAFPLLYTHFVKKGTFTLKQLVDWLTIDPAETFQLPYGRLEEGAPADVTIIDLEAERAIDPAHFASKGRNTPFAGWTCQGWPVATLVGGKLVWEEKEVAR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: ACPA_EMENI
Sequence: MSAEQNHGLEKDVGGPAAPAAAAPNAPAAAPGAPPAGMSAEEHRSRFGYGPLSHVNTKEAILPPFGGEFQPGLYKSVEARKFANPAPLGLSAFALTTFVLSCINMGARDITHPNIVIALAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWIAFAIVLTPGGFNIQTALTAENGDEAMFYNSFGLFLMGWFIFTTIMLFCTLRSTVAFFLLFLFLDLAFLLLGVGYIQRDDAGQPNPPVIKAGGFFGLLAAFAAWYNALAGIADSSNSFFIIPVAHFPWSPTGRARREKTERETV
What is the function of this protein?
High affinity monocarboxylate transporter (MCT) involved in acetate uptake.  Unlike other activities involved in acetate utilization, acpA is dispensable for growth on the acetate precursor ethanol.
What are the official names of this protein?
Acetate permease A, Monocarboxylate transporter acpA.
What is the protein family that this protein belongs to?
Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: ARGD_XANCP
Sequence: MSTAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDQGREYLDLSSGIAVSGLGHNDPDLMAALTEQAGKLWHTSNVFFSAPPLKLAEELVTASRFAQKVFLCNSGTEANEAAIKLVRKWASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEGYEPLPGGFRYVDFNDVPALESAMASGDVAAVMLEPIQGEGGVMPAAPGFLARVRALCDQHDALLVLDEIQCGMGRTGSLFAHWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAETMQFGAHGTTFGGNPLAAAVARVALRKLASPQIAENVARQSAALRAGLEALNAEFGVFAQIRGRGLMLGAVLAPAHAGQAGAILDLAAAHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLAIAAYVAQH
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXAC_ESCF3
Sequence: MTPFMTEDFLLDTEFARRLYHEYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNQCNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: CCA_METM5
Sequence: MKKLNINDYNDILNEVLNDIRPTELEKDKLKVFSDKIIAKIKDISKYPVLDIIQVGSTARDANLKDDHDLDIFLRFEKETDRDTLKESGLRIGKEVIDYFNGKSWVEYAEHPYVSGEIEKFNLDIVPCYGIENCEKIISAVDRTPLHNEFLIMSYKNKNLSDDIRLLKKFLKGLGIYGSDLKTAGFSGYLCELLILKYGGFLSLLSDVKNWRPNKSIVLNEIYEMYDLKKEHEFLNFDDSLVVYDPVDLNRNVAAALNEENLCKFIFYSKMFLENPSKEFFYGFDKKITDFLNIRERGYLLTLEISRPENIVEDVIYPQMEKIQKSINKLIKEHDFEYIRYQNFADENTCYLSWEFLIHELPDVKIRTGPPVYSEPGVVNFITHNEHYFVKGCNVCAYKTRKYKNIQILFEDIVNGKLRKIITYPKYVCPENAEIRLGTFVERT
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: TXND6_XENLA
Sequence: MAGKKRESSLQIALSNQEQWEEALSTKGLQVVDVYQAWCGPCKPTVSLFRKIKNELGDDLLHFAVAESDTIDSLVKYRGKCEPTFLFLAGGELVAVVRGANGPLLQKTIIEQLAAEKKVLNQGSERHVIKDEVLLEEEDEIAPVQAQTEDEELVPSGKSYTVAIIKPDAVAHGKTDEIIMKIQESGFEILANEERTMTESEAREFYQHRAGEEKFQELIQFMSSGPCHILIISKSEEDEDVIPAWREFIGPTDVEIAKKEKPESLRAQYGTEVLYNAVHGSNDREQASRELAFFFPNFKISNESLKELTSVKPERTLALIRPEILKERKDEILQSIKDAGFSIAMQKEVMLTEHQVQEFYKEHINEDYYPALLKQMTSGPVLALALVKDNAVGHWRNMLGPASLSQALSEAPDSLRAQFAPSDSETNQLHGSSTTEEAKKEINFFFPVEHTLATIKPDALEEHRDEILEQIQGAGFTISQIKEANLNREMAEEFYKEHKGKPFFEQLVNYMCRGPCLMMILSKENAVHEWRSLMGPTDPAEAQKVLPDSLRGKFAKSILQNAVHGSSNSDHAMEKIKFIFGDIDLDRIVHESFGETPETSASDISRNAAAQGDDPEQDESKEMEE
What is the function of this protein?
May be a regulator of microtubule physiology.
What are the official names of this protein?
Thioredoxin domain-containing protein 6, Thioredoxin-like protein 2, Txl-2.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity).
Protein: TIG_PSEA8
Sequence: MQVSVESTSALERRMTVGVPAERIETEVNKRLQQTARRAKIPGFRPGKVPMSVIRQRYEASARQEAMGDLIQETFYEAVVEQKLNPAGSPSVEPKSFEKGKDLEYIATFEVFPEFTVSGLEDIKVERLQAEVSDADVDNMLDVLRKQNTRFEVVERAAQNDDQLNIDFVGKIDGEAFAGGSAKGTLLVLGSGRMIAGFEEGLVGAKAGEERVLNLTFPEDYQNLDLANKAAEFTVTVNSVAEPKLPELNEEFFALFGVKETGLDGFRAEVQKNMERELRQAIKSKVKNQVMEGLLQANPIEVPKALIGNEVNRLRVQAVQQFGGNIKPDQLPAELFEEQAKRRVVLGLIVAEVVKQHELKADEGRVREMIEEMASAYQEPEQVVAWYFKNEPQLNEVRSVVLEEQVVDTVLQKATVTDKQVSYEEAVKPAEAPQAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: KHSE_XANP2
Sequence: MAVYTDVAPAELEAFLSGYDIGTLTSFHGIAEGVENSNFLVQTTRGSYILTLYEKRVNRDDLPFFIGLMEHLAARGLSCPQPVAQRSGAVLSEIAGRPAAMVTFLPGVSVRRPTAEHCAELGRGLAQLHLAGADFAMRRANNLSVAGWRPLFVAADGQADDVAPGLADAIAAELATLEANWPQGLPAGVIHADLFPDNAFFLDEKLSGIIDFYFACTDFLAYDVAVCLNAWCFEPDGSYNVTKGRALLSGYEAVRPLSGAEKAALPRLARGAALRFLLTRLVDWLNVPEGALVRPKDPLEYLKKLRFHQAVDSAQDYGLAA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.