PharMolix/UniProtQA huggingface dataset:
Protein: ABD18_HUMAN
Sequence: MGVSKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKIEEQSDCKILDGHFVSPMAHYVPDIMPIESVIARFQFIVPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPADCHNSSKTSVSATSEGLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFR
What are the official names of this protein?
Protein ABHD18, Alpha/beta hydrolase domain-containing protein 18, Abhydrolase domain-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1615_STRP8
Sequence: MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLMVNKASKNRVKPACSVYETCGGCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPIDNCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLARFIGELTKAFPQVKTVALNSNCSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRTFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGFAFAGKVKSVRGMDIISEAIEDAQKNAKAMGFDNAYYEAGKAEDIIPKWYKQGYRADAIIVDPPRTGLDDKLLKTILHYQPKQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV
What are the official names of this protein?
Uncharacterized RNA methyltransferase spyM18_1615.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: RS6_RHIL3
Sequence: MALYEHVFLARQDISAQQVDALVEQYKGVIEANGGKVGRIENWGLKSLTYRIKKNRKAHYALMDIDAPAAAVQEMERQMRISEDVLRYMTIAVEKHEEGPSAMMQKRDRDDRPREGGRGPREGGFGDRDRGPRPPREGGFGDRDDRPRRPREDRV
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SECG_STAAS
Sequence: MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
What is the function of this protein?
Involved in protein export.  Participates in an early event of protein translocation (By similarity).
What are the official names of this protein?
Probable protein-export membrane protein SecG.
What is the protein family that this protein belongs to?
Belongs to the SecG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FRLB_SHIFL
Sequence: MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY
What is the function of this protein?
Catalyzes the reversible conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine.  May function in a fructoselysine degradation pathway that allows S. flexneri to grow on fructoselysine or psicoselysine.
What are the official names of this protein?
Fructoselysine 6-phosphate deglycase.
Protein: TRPD_ALKCK
Sequence: MMKHVLNKCLMGESLSVQEAEQVMEQIMSGRATASQVASLITMMRVRGETAEEILGFAKGMRAYARKFPAVIEGTIDTCGTGGDGLGTFNISTASALVLASLGVPVAKHGNRSVSSKSGSADVLEELGINIQASVEEACQMLETTNLCFLFAPLYHQSMRHVAGPRKEIGFRTIFNLLGPLTNPAGARYQLLGVYDEAAALKMGEALRQLGSEHSLLVTGADGLDECAIHGDTHVVEVKDGRCETYRFSPDDVGLPLGNLADIQVDTPAESAALIRAIFSGDGPQAAKNIVALNAGAALYACGNASHIAEGVHYASKAIESKRVFRYLQSLQQQGRGIKHA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: API2_MYCTU
Sequence: MEAALAIATLVLVLVLCLAGVTAVSMQVRCIDAAREAARLAARGDVRSATDVARSIAPRAALVQVHRDGEFVVATVTAHSNLLPTLDIAARAISVAEPGSTAARPPCLPSRWSRCCCASPVRVHI
What is the function of this protein?
Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway.  Interferes with caspase-8 activation and binds to the host E3 ubiquitin-protein ligase RNF213, whose fusion partners have anti-apoptotic function.
What are the official names of this protein?
Apoptosis inhibitor Rv3655c.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Is secreted into the macrophage cytoplasm. Might be secreted via a type IV pili apparatus that seems to be encoded in the same operon.
Protein: RR15_NYMAL
Sequence: MVKNSPISVIPQEEKRGSVEFQVFNFTNKIERLTSHLELHRRDYLSQRGLRKILGKRQRLLVYLSKKNRVRYRELIGQLGIREPKTG
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PGPH_LISM4
Sequence: MKLAKKWRDWYIESGKKYLFPLLLVCFAVIAYFLVCQMTKPESYNVKLFQVAEKTIRSPQTVEDTEKTKEERTKASDAVEDVYVYNRETGQNRVALIQSLFAYVNEVNAEAQEKDTKNKEKAKKENKPAPAPTSTEDKLKNLKDKLSSNVSEKITSNISDEVFTTLIEAKSKDFNVMEDVVTTEVEKSMENKIRDENLNSVKIRARDDIELSAIPAYYKNVSKALVSYAIVPNEVYDEEQTDARRKEAAQSVVPVKILQGQVIVQEGQIVDRETYRQLKMLHLLDQKMPVKQYAGFAIFIIALAAILFLYTKKQTQPKAKKMQTMLIFSSVYLVSLFMLFIILFLETQNIANIAFLFPAAFAPMILKILLNEKYAFLSVIFIAVTSLLTFQNDATSGITIFILLSGATSVVMLRDYSRRSAIMLSGFMVGLINMIYVLLLLLINNSTLLQVSTLMALGYAFLGGFGAFILGVGVIPLFETIFGLLTTSRLVELANPNHPLLKKILMKAPGTYHHSMMVANLAEACADKIGANSLLVRVGCFYHDIGKTLRPPYFVENQLQGINPHDRLTPEQSRDIILSHTKDGAEILKENHMPQPIIDIALQHHGTTLLKYFYFKAKETNPDVKEADYRYSGPKPQTKEIAIINISDSVEAAVRSSTEPTMAKITEIIDGIIKDRFLDGQFTECDITIQEIKIIRDTLIATLNGIYHQRIQYPDDKD
What is the function of this protein?
A phosphodiesterase (PDE) that hydrolyzes cyclic di-3',5'-adenylate (c-di-AMP); there are at least 2 PDEs for c-di-AMP in this bacteria (this and pdeA), this may be the major PDE for growth in liquid culture (PubMed:25583510).  During host infection c-di-AMP is secreted into the host cytoplasm which leads to interferon-beta production and secretion by the host (Probable).  The cytoplasmic HD domain binds and hydrolyzes c-di-AMP to 5'-pApA; has very low activity against c-di-GMP, does not hydrolyze ppGpp (PubMed:25583510).
What are the official names of this protein?
Cyclic-di-AMP phosphodiesterase PgpH, c-di-AMP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the PgpH phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YCF68_ORYSA
Sequence: MAYSSCLNRSLKPNKLLLRRIDGAIQVRSHVDLTFYSLVGSGRSGGGTTAPLFSRIHTSLISVWRAISRAQVEVRPQWENGAPNNASSQTKNYEITLSFWGDGGIVPFEPFFHAFPGGLEKAAINRTSLILPS
What are the official names of this protein?
Uncharacterized protein ycf68.
What is the protein family that this protein belongs to?
Belongs to the ycf68 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PCCR_CERS4
Sequence: MAQKLYAGAKLRELRVKLGLTQKVFAERLGASLPYLNQMENNHRPVSATVVLALAQEFGVDVTKLTTSEAERIVTDMREALADPVFTDSPPLADLRLVASNAPAFARAFLDLHRAYRQTHERLASLDEALGRDEADLRPSPWEEVRDFFHYCDNYLDAVDRAAEHYAAPGGVRRDVFSAAMETLTRAGLDLQISDMPAIRSREGNALRLSARAAAPTQRFQLLHQVALLTQNDLLEATLDLARFQTAEAREIAKIGLANYFAGAALLPYRPFLQAAAETRHDLERLADLFGASIEQVAHRLSTLQRPGAKGVPFFFVRVDQAGTITKRHSATRFQFARFGGACPLWNVHRAFETPGRFLRQLAQTPDGVRYLLLARDVSKPGGSFTAPVRRYAIGLGCEVQHADALVYADGLDLKGSFEPIGISCRICDRQECHQRSVPPLEKRLRVDPDRRGLLPYEIVD
What is the function of this protein?
Transcriptional regulator that controls propionyl-CoA assimilation through the methylmalonyl-CoA pathway via regulation of pccB expression.
What are the official names of this protein?
Propionyl-CoA carboxylase regulator.
What is the protein family that this protein belongs to?
Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.
Protein: SDC4_RAT
Sequence: MAPVCLFAPLLLLLLGGFPVAPGESIRETEVIDPQDLLEGRYFSGALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
What is the function of this protein?
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
What are the official names of this protein?
Syndecan-4, SYND4, Ryudocan core protein.
What is the protein family that this protein belongs to?
Belongs to the syndecan proteoglycan family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Protein: FABZ_MAGSA
Sequence: MSMDTANNDQGTDLGKVIDISRIIQMIPHRYPFLMVDRVVQVVANESAVGIKNVTINEPFFQGHFPSRPVFPGVLIIESMAQTAAVLVVETLGESAEGKLVYFMSVENCRFRKPVGPGDQLMIHVFKERSRGNVWKFRGEAKVDGVLVAEATYAAMILDEK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMD_METMP
Sequence: MNASEAVYKAILDSGVDFVTSVPCANLKTVLNYLNDDKDIQHIPVTREEEGIGVCTGAYLGGRKTALLMQNSGLGNSINAIGSLVKVYKIPILIIISHRGDLKEKISAQIPMGQWTKKLLETVEIPYFSPKTPDEAYKLIKDASELSINMEYPVAILLDALYWEHDK
What is the function of this protein?
Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid).  Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.
What are the official names of this protein?
Sulfopyruvate decarboxylase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ComD family.
Protein: MNHF2_STAEQ
Sequence: MIEMFTQIFIISALVIFGMALLVCLVRLIKGPTTADRVVSFDASSAVVMSIVGVMSVIFNSVSYLDSIMLIAIISFVSSVSISRFIGEGRVFNGNHKRHR
What are the official names of this protein?
Putative antiporter subunit mnhF2, Mrp complex subunit F2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRFN4_RAT
Sequence: MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARSFGDLESLRSLHLDGNRLVELGSSSLRGPVNLQHLILSGNQLGRIAPGAFDDFLDSLEDLDVSYNNLRQVPWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQLSRLDLTSNRLATLAPDPLFSRGRDAEASPSPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPTLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPVPTMHWVGPDDRLVGNSSRAWAFPNGTLEIGVTGAGDAGAYTCIATNPAGEATARVELRVLALPHGGNTSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSQHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPATPLCHALQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGTSPMPKSHPPRSPPPRPQRSCSLDLGDTGGCYGYARRLGGAWARRSHSVHGGLLGAGCRGMGGSAERLEESVV
What is the function of this protein?
Promotes neurite outgrowth in hippocampal neurons.  May play a role in redistributing DLG4 to the cell periphery (By similarity).
What are the official names of this protein?
Leucine-rich repeat and fibronectin type-III domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the LRFN family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: METL2_ARATH
Sequence: MAKTDKLAQFLDSGIYESDEFNWFFLDTVRITNRSYTRFKVSPSAYYSRFFNSKQLNQHSSESNPKKRKRKQKNSSFHLPSVGEQASNLRHQEARLFLSKAHESFLKEIELLSLTKGLSDDNDDDDSSLLNKCCDDEVSFIELGGVWQAPFYEITLSFNLHCDNEGESCNEQRVFQVFNNLVVNEIGEEVEAEFSNRRYIMPRNSCFYMSDLHHIRNLVPAKSEEGYNLIVIDPPWENASAHQKSKYPTLPNQYFLSLPIKQLAHAEGALVALWVTNREKLLSFVEKELFPAWGIKYVATMYWLKVKPDGTLICDLDLVHHKPYEYLLLGYHFTELAGSEKRSDFKLLDKNQIIMSIPGDFSRKPPIGDILLKHTPGSQPARCLELFAREMAAGWTSWGNEPLHFQDSRYFLKV
What is the function of this protein?
Probable methyltransferase.
What are the official names of this protein?
Methyltransferase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
Protein: ANMK_SYNS9
Sequence: MRCLGLMSGTSADGVDAVLADFRGSPNHPQWDLIRHVHHPYPEALRHRVVSAGQGEPSRADQWLDLAEAITEAQAMAARSCDPHAEAVLVGCHGQTIWHRPPTSQQRGASWQLLQAPLLAQLLERPVVHDFRAADLALGGQGAPLVPKADAALLGGTKGWRALLNLGGIANLTLIPPCCGPDRDASVQGWDCGPANSLIDLAVQQFSNGTLLFDRGGAMAKAGHSDETSIRRWLQEPYFQSPPPKSTGRELFGRANLQQRLNDLGRDCSSQDAVATLTSFSAAVVAQDLEQLMQRDRIRPLELIVAGGGRHNPVLMDQLQQRCRGLQLSSSQEMGLPVEAREALVFALLAWWHQRKHPGNSPSITGATRESVLGVLVHPG
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: ARGC_SALTI
Sequence: MLNTLIVGASGYAGAELVSYVNRHPHMTITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDVRDFSADVDVVFLATAHEVSHDLAPQFLQAGCVVFDLSGAFRVNDRAFYEKYYGFTHQYPELLEQAVYGLAEWNADKLNTANLIAVPGCYPTAAQLSLKPLIDGGLLDLTQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIAAHLGAEVIFTPHLGNFPRGILETITCRLKAGVTHAQVADVLQKAYGDKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIVVATEDNLLKGAAAQAVQCANIRFGFAETQSLI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_BURPS
Sequence: MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEIDAFSREKMDGTLAELLEERDGVAHLLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: HEM3_BACVZ
Sequence: MRTIKVGSRRSKLAMTQTKWVINKLKELNPSYNFEIREIVTKGDRILDVTLSKVGGKGLFVKEIEQALLHQEIDMAVHSMKDMPAVLPEGLVIGCIPKREDPRDALISKGHQKLDGIKEGGIIGTSSLRRSAQILAERPDLTIKWIRGNIDTRLQKLETEDYDAIILAAAGLSRMGWKDDVVSEFLEPDRCLPAVGQGALAIECRESDEELLKLFAQFTDEYTQRTVAAERAFLHAMEGGCQVPIAGYASVNDRDEVELVGLVASPDGKTIYKETAAGHDPEEIGKRCAAMMSEKGAKALIDSVKQELDQDGK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RPIA_LACH4
Sequence: MAKTEQDRLKKEAAEKAASMVKSGMILGVGTGSTVAFFIDALGKRKDNDGLKLKAIVTTSNRSKNQLEGLGFKVSELADVDQVDLTVDGSDRVADNLDGIKGGGGALTLEKNVAINSKKIIWIVDESKLVHRLGGFPLPVEVLPISCEQNFKRFKQEGLKPQWRMDSDKRYITHYGNYIIDLAADPVPAPHGLADYLDHTVGVVEHGLFLDMCDEVIIAHSDGTIEDKIK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: VE7_HPV30
Sequence: MHGKVTTIPEYILDLVPQTEIDLHCYEQLNSSEEEDEDEVDNLQKQPQQARQEEQHPCYLINTQCCRCASAVQLAVQSPTKELRALQQMLMGALELVCPLCATRR
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: MURC_BLOFL
Sequence: MQSSYFKNGILPIINRFYTKQIHFVGIGGIGMCGLAMLLLAQGYCITGSDIAQNDMIRSLLKLGIKIFFGHRDSNINQEINIVVISSAIDINNPEVQQAKRLKIPVIHRVKILSELMRYKYGIAIAGTHGKTTTVSMLTNIYVEAGLDPTFVNGGIIRSQGVSARLGYGNDFIAESDESDKSFLRLCPVVAVITNIDTDHMNTYHQNFEYLQEVFIKFLDKLPMYGYAVVCIDDPVVRKILPRINRKIITYGFSKDATLCIVKYYQYREKSNFTILIKNNKELQVVLNTPGYHNALNAAASIAVAIEEGIRDTVILKSMSNFTGTNRRFEFLGNYPLNIINGRVGKVMVIDDYGHHPAELRSTIIAIRTGWSDHRLVMVFQPHRFTRTHELYDNFVRVLSTVDVLLMLDIYSAGEQPIMGINAQSLCDSILKYAKVQPIFVQNECFLLKFLMNLLRDKDLLLIQGAGTISEIVKALFIKR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PABP_ASPFU
Sequence: MSAEVSTTPAADNTVNGTPEATNAAATSAPEVTAVESASPSTTPSASQPHSASLYVGELDPSVTEAMLYELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNNTADGERALEDLNYTLIKGKPCRIMWSQRDPALRKTGQGNVFIKNLDAAIDNKALHDTFAAFGNILSCKVAQDEFGNSKGYGFVHYETAEAANNAIKHVNGMLLNDKKVFVGHHISKKDRQSKFEEMKANFTNVYIKNIDQEVTDEEFRKMFEKFGEITSATLSRDQEGKSRGFGFVNFSTHDSAQAAVDEMNDKEIKGQKLYVGRAQKKHEREEELRKQYEAARLEKASKYQGVNLYVKNLTDDVDDEKLRELFSPFGTITSAKVMRDTVTTGETSESEKEKEKESNKENEKEGEEKTEEKPKESEEEPKKTEKKILGKSKGFGFVCFSSPDEASKAVTEMNQRMVNGKPLYVALAQRKDVRRSQLEASIQARNTIRQQQAAAAAGMPQPYMQPAVFYGPGQQGFIPAGQRGGMPFAPQPGMVMGIPGGRPGQYPGPFPGQQGGRGMGPNQQIPPNFQGIPMGAMQGPGGIPNGMGYPQMAQVQFGRGAGGRGQVPGMPMGQGIRGPGYGQGRGGAPVQGGPRPQGGRGQPAAAPPAAGREEVPATGGLTAQTLSAVPPPQQKQMLGEALYPKIQAQQPELAGKITGMLLEMDNNELLGLLEDEEALRAKVDEALSVYDEYMKNKGEGEAPAESAKPKEDAAETATEENKS
What is the function of this protein?
Binds the poly(A) tail of mRNA.  Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.  In the nucleus, involved in both mRNA cleavage and polyadenylation.  Is also required for efficient mRNA export to the cytoplasm.  Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation.  In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein, cytoplasmic and nuclear, PABP, Poly(A)-binding protein, Polyadenylate tail-binding protein.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y277_HALH5
Sequence: MDNRYPIGQFNCPSEVQEKDIQMWIKEITTLPSRLHALTVSLDELELTKTYRENSWNVRQLIHHISDSHLNGYMRMKLALTEDNPVVKTYEESEWAKLIDYELPIRVSLQLLESLHERWTYLLKNLTATQLQRTYQYPDGSIMRIEQSIALYAWHGNHHLAHIQQALIRTK
What is the function of this protein?
Possible metal-dependent hydrolase.
What are the official names of this protein?
Putative metal-dependent hydrolase BH0277.
What is the protein family that this protein belongs to?
Belongs to the metal hydrolase YfiT family.
Protein: LYSC2_CAPHI
Sequence: KVFERCELARTLKELGLDGYKGVSLANWLCLTKWESSYNTKATNYNPGSESTDYGIFQINSKFWCNDGKTPNAVDGCHVSCSELMENNIAKAVACAKQIVSEQGITAWVAWKSHCRDHDVSSYVEGCTL
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
What are the official names of this protein?
Lysozyme C-2, 1,4-beta-N-acetylmuramidase C-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
Protein: ASNA_THEPA
Sequence: MEESSMESDNGLNLRNDVKNLVEQETYKWIFVGGKGGVGKTTISCSLSSILSERRESVLLLSTDPAHSLSDAFNQKFTDTPTLVNGYENLYAMELDVTRVADTGFGLNETKMFLQTIPELFQMLPGIDEALSFSELLQSVQSMKYSVIVFDTAPTGHTLKFLNLPDTLDKLLESFLKVESLCGVAMKLFSALNNSLPKEEIFQKLKRFKSNLTLIMNQMKDPNRTTFVCVCIPEFLSVYETERLIQSLAKTDIDCSYIIVNQVLSYINLEEHVKNTQNSLENLSPENKKVLDCFFELVLEQQNNLNGRLSIQRKYIEDIKQLYEGFFNIVAIKQYKYEVRGSEAIKEFSKALLKHSPIPDS
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: RLMN_ACIB3
Sequence: MSSAVVVSSENLDGQQQSSSTPASPAAEKVNLLGMSRAELEKFFEDIGEKKFRAGQVMKWIHQYFVTDFAEMTNISGKLRAKLEQICEIKAPEVVHRHYSKDGTRKWVFRVGEGSGSLVETVLIPAEDKTGSRKTLCISSQVGCALDCSFCSTGKQGFQRDLTPDEIIGQLWMANYSYMEEVPVAERERSVTNVVMMGMGEPLLNYDAVLSSMHIMLDDFAYGMSKRRVTLSTSGVVPKIDQLAKDIDVALAISLHAPNDELRNELVPINKKYPLAQLIAACQRYIAKDGNESARKHVTIEYVMLEGVNDQPEHAQQLLKLLKNLPSKINLIPFNPFPHAPYGRSSRNRIISFQKTLSDAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRAEQWQKKVAQRQEILRTQG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.