PharMolix/UniProtQA huggingface dataset:
Protein: NUOK_BURCM
Sequence: MLTLAHYLVLGAILFAIAIVGIFLNRRNIIIILMAIELMLLAVNTNFVAFSHYLGDVHGQIFVFFVLTVAAAEAAIGLAILVTLFRKLDTINVEDLDQLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HOK_ECOLX
Sequence: MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system.  Part of the plasmid-stabilizing activity of plasmid R1; when R1 is lost cells die rapidly.  When overexpressed kills cells within 5 minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:3019679).  Its toxic effect is partially neutralized by antisense RNA Sok.
What are the official names of this protein?
Protein Hok.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: POLS_EEEV
Sequence: MFPYPTLNYPPMAPINPMAYRDPNPPRQVAPFRPPLAAQIEDLRRSIANLTLKQRAPNPPAGPPAKRKKPAPSLSLETKKKRPPPPAKKQKRKPKPGKRQRMCMKLESDKTFPIMLNGQVNGYACVVGGRVFKPLHVEGRIDNEQLAAIKLKKASIYDLEYGDVPQCMKSDTLQYTSDKPPGFYNWHHGAVQYENNRFTVPRGVGGKGDSGRPILDNKGRVVAIVQGGVNEGSRTALSVVTWNQKGVTVKDTPEGSEPWSLATVMCVLANITFPCDQPPCMPCCYEKNPHETLTMLEQNYDSRAYDQLLDAAVKCNARRTRRDLDTHFTQYKLARPYIADCPNCGHSRCDSPIAIEEVRGDAHAGVIRIQTSAMFGLKRHGVDLAYMSFMNGKTQKSIKIDNLHVRTSAPCSLVSHHGYYILAQCPPGDTVTVGFHDGPNRHTCRLAHKVEFRPVGREKYRHPPEHGVELPCNRYTHKRADQGHYVEMHQPGLVGDHSLLSIHSAKVKITVPSGAQVKYYCKCPDVREGITSSDHTTTCTDVKQCRAYLIDNKKWVYNSGRLPRGEGDTFKGKLHVPFVPVKAKCIATLAPEPLVEHKHRTLILHLHPDHPTLLTTRSLGSDANPTRQWIERPTTVNFTVTGEGLEYTWGNHPPKRVWAQESGEGNPHGWPHVVVVYYYNRYPLTTIIGLCTCVAIIMVSCDHPCGSFSGLRNLCITPYKLAPNAQVPILLALLCCIKPTRADDTLQVLNYLWNNNQNFFWMQTLIPLAALIVCMRMLAALFCCGPAFLLVCGAWAAAYEHTAVMPNKVGIPYKALVERPGYAPVHLQIQLVNTRIIPSTNLEYITCKYKTKVPSPVVKCCGATQCTSKPHPDYQCQVFTGVYPFMWGGAYCFCDTENTQMSEAYVERSEECSIDHAKAYKVHTGTVQAMVNITYGSVTWRSADVYVNGETPAKIGDAKLIIGPLSSAWSPFDNKVVVYGHEVYNYDFPEYGTGKAGSFGDLQSRTSTSNDLYANTNLKLQRPQAGIVHTPFTQAPSGFERWKRDKGAPLNDVAPFGCSIALEPLRPENCAVGSIPISIDIPDAAFTRISETPTVSDLECKITECTYASDFGGIATLPTNPVKQETVQFIVHQVLQLLKRMTSPLLRAGSFTFHFSTANIHPAFKLQVCTSGITCKGDCKPPKDHIVDYPAQHTESFTSAISATAWSWLKVLVGGTSAFIVLGLIATAVVALVLFFHRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: CLPB1_SYNY3
Sequence: MQPTDPTKFTEQAWDAIVKSQEVARRYKNTNLEVEHILLALLEQDMGLAARIFQRAAVDGEGLRQQLEIFTNRQPKQAYVEQLYLGRSLDVMLDRADAARSSWEDKFISVEHLLVGFAEDDRVGRKTLRAFNLDPQDLELAIKAIRGSQKVTEPNQEEKYEALDKYGRDLTEQARQGKLDPVIGRDEEIRRVIQVLSRRSKNNPVLIGEPGVGKTAIAEGLAQRIINGDVPESLKNRQLISLDMGSLIAGAKYRGEFEERLRSVMKEVTNSDGQIILFIDEVHTVVGAGGREGSGSMDAGNLLKPMLARGELRCIGATTLDEYRKNIEKDPALERRFQQVYVKQPSVDDTISILRGLKEKYEVHHGVKITDSALVAAATLSHRYIQDRFLPDKAIDLVDEAAARLKMEITSKPVELEDIDRRLMQLQMEKLSLEGEEKRPGLGADKSSKERLEKIQQEITELEGQQQELSGQWLSEKQMLEEINTLKEKEQELRLQVEKAERATDWEKAAKIKYGELEVLQHDIEEKESKLLEIQGSGNTLLREQVTESDIAEIVAGWTGIPMNRLMETERQKLLQLEGHLHQRVIGQKEAVAAVSAAIRRARAGMKDPSRPIGSFLFMGPTGVGKTELARALAGFLFDSEEAMVRIDMSEYMEKHAVSRLIGAPPGYVGYEEGGQLSEAVRRRPYSVVLLDEVEKAHLDVFNILLQVLDDGRITDSQGRVVDFRNTIIVMTSNIGSDHILSLSADDADYDKMQKQVLQSLRKHFRPEFLNRIDDLIIFHTLKRDELRRIVVLQIKRIEKLLDEQKITLSLSDAALDHIVSAGYDPTYGARPLKRAIQRQLENPIATKILENTFVAGDKILIDCVDGQLIFDKEIEPTTLPEEPEENITAVEVEVLSS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB 1.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y321_METJA
Sequence: MTNNDKIVAIVTSIAVICISLTVIFCDTLVLAVGVPTLVLLWLVFLGWINNKKLDKGEMRRAITGSIVIAFFIILIAISKNPDIYSNNKEIFSLFFGMVTTIIGYYFGYRSGKESKNSSGNE
What are the official names of this protein?
Uncharacterized protein MJ0321.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UB2R2_HUMAN
Sequence: MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination.  May be involved in degradation of katenin.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 R2, E2 ubiquitin-conjugating enzyme R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: LGT_PROM1
Sequence: MEHIFLELRSPGPDLFQLGPFSLRWYGLLIAISVLVGLNLSSELASKKGLKKSLINDLLPILVLASVIGARIYYVAFEWRNYTGKNFWSSINFLNLNIPLPSALEIWGGGIAIHGALIMGTLSIIFFCRWRKEPFWDVIDVLVPSVALGQAIGRWGNFFNNEAFGIPTNLPWKLFIPYRFRPEIFSTQDYFHPTFLYESVWNIFVFGILIFLFRKSNKKELKLPPGSLSCLYLITYSLGRFWIEGLRTDPLCLGGVPPFCEGGLRIAQLISLFLISAGLLGIWRIYVSKKALPDPSSINGRNQ
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAHM3_MOUSE
Sequence: MDRFRMLFQHLQSSSESVMNGICLLLAAVTVKIYSSLDFNCPCLERYNALYGLGLLLTPPLALFLCGLLVNRQSVLMVEEWRRPAGHRRKDLGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSNSVDPEKFLDFANMTPRQVQLFLAKVPCKEDELVKNSPARKAVSRYLRCLSQAIGWSITLLVIVVAFLARCLRPCFDQTVFLQRRYWSNYMDLEQKLFDETCCEHARDFAHRCVLHFFANMQSELRALGLRRDPAGGIPESQESSEPPELREDRDSGNGKAHLRAISSREQVDQLLSTWYSSKPPLDLAASPRRWGPGLNHRAPIAAPGTKLCHQLNV
What is the function of this protein?
Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP (PubMed:29681531).  Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531).  CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances (PubMed:29681531).
What are the official names of this protein?
Calcium homeostasis modulator protein 3.
What is the protein family that this protein belongs to?
Belongs to the CALHM family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane of epithelial cells including taste cells.
Protein: PARL_MOUSE
Sequence: MALQGWVQRGWRCGPAWAPPLGGGYRELSATQAPRLLGRRFNLFVQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPIRTLVKPFFFTIGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
What is the function of this protein?
Required for the control of apoptosis during postnatal growth (PubMed:16839884).  Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (PubMed:16839884).  Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity).  Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).  Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide.
What are the official names of this protein?
Presenilins-associated rhomboid-like protein, mitochondrial, Mitochondrial intramembrane-cleaving protease PARL.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [P-beta]: Nucleus. Note=Translocated into the nucleus by an unknown mechanism (By similarity).
Protein: ENO_ASHGO
Sequence: MAISKVYARSVYDSRGNPTVEVEVTTENGTFRSIVPSGASTGVHEALELRDGDKSKWLGKGVTKAVSNVNDIIAPALLSANVDVKDQKAVDALMLTLDGTPNKSKLGANAILGVSMAVAKAAAAEKKVPLYQHLADLAGSSTTPFVLPVPFLNVLNGGSHAGGALALQEFMIAPTGAESFSEALRMGSEVYHNLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGYEGKIDIALDCASSEFFKDGKYDLDFKNPESDSSKWLSGQELADLYKKLVEKYPIVSIEDPFAEDDWEAWSHFYKNAGVQIVADDLTVTNPTRIATAIQKKAADALLLKVNQIGSLTESIQAAKDSFDATWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAKLNQLLRIEEELGSKAIYAGKKFHNANKL
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_PSEMZ
Sequence: MLTLKLFVYAVVIFFISLFIFGFLSNDPGRNPGRKE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: KUP_ENTFA
Sequence: MLHKAEGFDRRKFTMAGILVAMGVVYGDIGTSPLYVMKAIVGDNGGLARVSESFILGSVSLIFWTLTILTTIKYVVIALNADNHGEGGIFSLYTLVRKKSKYLIIPAMIGGAALLADGVLTPAVTVTTAIEGLRGIPAFFERFGNDQTIIVVITLTIILILFSVQRFGTELVGKAFGPIMFLWFTFLGIIGLMNFSQDWTVIRALNPYYALQLLVSPENKLGLFILGNIFLATTGAEALYSDLGHVGKMNIRISWPYIKICLILNYLGQAAWLLTVKENPEMQALAEINPFFQMIPRGILVFGVVFATIAAVIASQALISGSYTLVSEAIKLKLLPRLKIIYPGSNIGQMYIPAVNLILWLACSAIVLAFRTSTHMEAAYGLSITITMLMTTILLLFYLLDKIPAWSAYLISLFFAAIEVVFFFSSAAKFFHGGYVAVGMAVFLLCIMIIWERGNEIKEATAEQVSLKKYVPQLKALKEDTSVPMYQTNVVFLTSDRVDGEINRNIIYSILDKQPKRANVYWFVNVQVTDEPFTQEYSVDMLGTDFIVQVQLYLGFHISQEVNVYLRQIVHDLMKTGRLPKQPQRYSLTPGREVGDFQFVLIQEELSNVSELKKWDRQIMQAKLAIKNLTTSPESWFGLEYSEVKYESVPLIIGPQRKTHLVERKNRS
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HKM5_ASPHA
Sequence: METPTPPLPSKDQLFPPLIQLVRALLWVLVITIGGAIVQRLFFHPLRKIPGPLTAAISGWDEFYHNIWRDGEWCKTYPKLHKEYNSPVIRIGPNHVHLNDIDAYETVFRVGTNFYKDKTFYTCADNDGSIFSLCDRDEHSERRKVLSSLFSKQAAEMTAPKVMSKLNELLDFMITQSKEGKACNITDLFRALAINWVADTLLGDCGDVVTYAETKPDLLEDIDGLSKLIPTLRFFPYLIPTLNSLAPSTSPAGVAKFKKICENYTRPRINDPIKNISQRSRASVVELLIAHRHEVYHKPPTVDYLAEEAFTFIDAGVDTTGGTLVAAIYHILRDPGILRRLREELDESQLFLSKGTPIDFKKLGNLPYLNAVINESHRIWPALPGPLPRVVPPEGLQVGSFFVPSGTILSSTHHCLHYNETVFPEPKKFKPERWLRTDKWEGDRYLNPYSRGSRACIGINLAQMELRLTLGHLFSHYDLQLCEPTLSSLEWKDHFVAHPKAPVMIHIGFRKA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines (PubMed:33242032).  The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable).  Xenocockiamide A is then converted to hancockiamide D via a series of hydroxylations and O-methylations (Probable).  The tyrosinase hkm6 may catalyze an aromatic hydroxylation, then the 2-oxoglutarate-dependent Fe(II) dioxygenase hkm4 and the FAD-dependent phenol hydroxylase hkm7 may catalyze consecutive hydroxylations to install 2 more hydroxy groups, and the methyltransferase hkm8 probably catalyzes two methylations using 2 molecules of S-adenosyl-L-methionine (SAM) (Probable).  The NRPS hkm11 activates and transfers trans-cinnamate supplied by the PAL hkm12 to hancockiamide D and produces hancockiamide A (PubMed:33242032).  NRPS Hkm11 has the flexibility to tolerate the bulky hancockiamide G as a substrate and the absence of the acetyl-transferase hkm3 opens up the opportunity for hkm11 to introduce a second N-cinnamoyl moiety (PubMed:33242032).  The cytochrome P450 monooxygenase hkm5 catalyzes the methylenedioxy bridge formation, converting hancockiamide A into hancockiamide G (PubMed:33242032).  Hkm5 can also convert hancockiamide B into hancockiamide C, and hancockiamide D into hancockiamide H (PubMed:33242032).  The N-acetyltransferase hkm3 finally transfers an acetyl group to 1-N of piperazine, converting hancockiamide A into hancockiamide B and hancockiamide G into hancockiamide C (PubMed:33242032).
What are the official names of this protein?
Cytochrome P450 monooxygenase hkm5, Hancockiamides biosynthesis cluster protein 5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: STP_BPT4
Sequence: MSNFHNEHVMQFYRNNLKTKGVFGRQ
What is the function of this protein?
Plays a role in the inactivation of several host DNA restriction systems including EcoprrI or EcoR124I.  As a consequence, it activates the host anticodon nuclease PrrC.  However, the phage-encoded RNA repair enzymes normally offset the damage.
What are the official names of this protein?
T4 Suppressor of prr, Stp.
Protein: RRT13_YEAST
Sequence: MKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIRNNGECSYATNSASPCAKILGAMYTLRGHRALVGLLGLSDKFLVSASVDGSIRCWDANTYFLKHFFDHTQLNTITALHVSDEVLVSGSEGLLNIYDLNSGLLVRSDTLSGADNVWNVSFKDNTLVAAVERDKRNLLEILDFS
What is the function of this protein?
May be involved in the modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 13.
Protein: GAO_LACSA
Sequence: MELSITTSIALATIVFFLYKLATRPKSTKKQLPEASRLPIIGHMHHLIGTMPHRGVMDLARKHGSLMHLQLGEVSTIVVSSPKWAKEILTTYDITFANRPETLTGEIIAYHNTDIVLAPYGEYWRQLRKLCTLELLSVKKVKSFQSIREEECWNLVKEVKESGSGKPINLSESIFTMIATILSRAAFGKGIKDQREFTEIVKEILRQTGGFDVADIFPSKKFLHHLSGKRARLTSIHKKLDNLINNIVAEHHVSTSSKANETLLDVLLRLKDSAEFPLTADNVKAIILDMFGAGTDTSSATVEWAISELIRCPRAMEKVQAELRQALNGKEKIQEEDIQDLAYLNLVIRETLRLHPPLPLVMPRECREPVNLAGYEIANKTKLIVNVFAINRDPEYWKDAEAFIPERFENNPNNIMGADYEYLPFGAGRRMCPGAALGLANVQLPLANILYHFNWKLPNGASHDQLDMTESFGATVQRKTELLLVPSF
What is the function of this protein?
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:20351109).  Catalyzes three consecutive oxidations of germacrene A to produce germacrene A acid (PubMed:20351109).  Could also catalyze the three-step oxidation of non-natural substrate amorphadiene to artemisinic acid (PubMed:20351109).
What are the official names of this protein?
Germacrene A hydroxylase, Germacrene A oxidase, LsGAO.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: ISPH_BACP2
Sequence: MNVIKISPRGYCYGVVDAMVIAKNAALDKNLPRPIYILGMIVHNKHVTDAFEEDGIYTLDGPNRLDILKQVESGTVIFTAHGVSPEVRQIAEEKGLVAIDATCPDVTKTHELISEKTADGYDIIYIGKKGHPEPEGAVGVAPDKVHLVESEADIEALDLTSDKLLITNQTTMSQWDVHDLMELIKEKYPHVEYHQEICLATQVRQEAVSEQAGQADLTIVVGDPKSNNSNRLAQVSMEIAGTQAYRIGDLSELKLEWLQGVNTVAITAGASTPTPITKEVIRFLENYEPDDESTWKIERSVPLSKILPRVKTKK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NANOG_MOUSE
Sequence: MSVGLPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCTEAASPRPSSEDLPLQGSPDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLIQKGSAPVEYPSIHCSYPQGYLVNASGSLSMWGSQTWTNPTWSSQTWTNPTWNNQTWTNPTWSSQAWTAQSWNGQPWNAAPLHNFGEDFLQPYVQLQQNFSASDLEVNLEATRESHAHFSTPQALELFLNYSVTPPGEI
What is the function of this protein?
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768).  Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages.  Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes.  Acts as a transcriptional activator or repressor.  Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'.  Binds to the POU5F1/OCT4 promoter (By similarity).  Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression.  When overexpressed, promotes cells to enter into S phase and proliferation.
What are the official names of this protein?
Homeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog.
What is the protein family that this protein belongs to?
Belongs to the Nanog homeobox family.
Protein: CLP1_MOUSE
Sequence: MSEESNDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK
What is the function of this protein?
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.  dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.  Plays a key role in both tRNA splicing and mRNA 3'-end formation.  Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:23474986, PubMed:24766809).  Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809).  Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation.  Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC).  However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
What are the official names of this protein?
Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyadenylation factor Clp1, Polynucleotide kinase Clp1, Pre-mRNA cleavage complex II protein Clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YPX2_CAEEL
Sequence: MFLKDLGCGTNTCQNLPFDVTPVYSVFDFKGRIKFETDLNAPEVQANLGKVGYLVNEDIEGLIRYDEYYSEEDDLFAYTNGDYPNQFYACQLREHGNMRYKFVRTLGYAFTAITVPENDPIYTIIVYDDGLPEPSTTTLSPSQHVFQTNPIWTILKNSKNGTQGVGAVNLPWTPPVSASPIEPTNVCLLNGNSSVLSRCGEIDRMLQFFDDTHVYIGFKDSIQDASNTYIYSYIGYAFTSSENTCGIPLEPIRELYKYGVGFTSVAGEKYTELISNGYSLTRKVLGYTIDCASATNGELVVTIPDGLSTATPLSSLSTASTPTKTVGFYTRPVQIVSNPSGGLQGYWIEYFDTSSFPRNPLYSTNVCLFLANSSVITRCGHARNLYQYHDTVDNFVFISLYTFGRTVESLPLGVAFETSEKTYYNVVAGDDYQNLLDQGYNITGNIMGYTIDCKDANDEFVYGYLPNSDEFETTTVAGRYGFKVDTVKIVFPNTGSVEYEDNGYWVNTPKRPLVTFVRDTNVCVFREDLETVEKCGATKPLYLYINKNNGGYFMGIQSFGRNLTSTELVGVAFESTENTCGLKLYPMREFYGRPGYDVHAGEDYEEITAAGYNQTGNIMGYTVDCRDAIGGTVYGHLPNTIPEEPTKPSQSTSPSTPSTPPNRIGFYVERVFLVGPKSGIAGQQGYTLKIVSNLDPDTEVRGETNVCVITGNFLEIDTCADFTQTFNSYFDANDNYYYVARDTGRPVTKAGIIGTTFSSQENLCGLNVVPIRELYKEGVGYNAVAGDDYQSLLDEGYTLNGRIMGYTVDCNDAENDFVYGFLPTTTTITKSTVSTTTAPLNRFRLSPVYIIYPTEYYLQNQQEGSHVATRLGFIQHDGAGVTNACVFLSDPSIVALCGTTAPLYLYFDRVRVAYFVGTHSAGRNVSIERAATVFESAGNTCGFTLLPLREFYKDGTGYNLHAGDDYELLVNGGFVATGNIMGYAPDCRDNGFHEPDLKDYVSPTTTTRTPEPTDTSEPGKCNKNLVTLGTTNKNRTFEMNVQYGAVTTLENKRTMTVYCQGTPTYNIYMTWDGNAVSGRNTVSGLVELNLECSLVDGKDNWVTENSNHRVTFVRCDEAYNYLQQ
What are the official names of this protein?
Uncharacterized protein F40H6.2.