PharMolix/UniProtQA huggingface dataset:
Protein: XYL1_ASPNC
Sequence: MASPTVKLNSGYDMPLVGFGLWKVNNDTCADQIYHAIKEGYRLFDGACDYGNEVEAGQGIARAIKDGLVKREELFIVSKLWNSFHDGDRVEPICRKQLADWGIDYFDLYIVHFPISLKYVDPAVRYPPGWKSEKDELEFGNATIQETWTAMESLVDKKLARSIGISNFSAQLVMDLLRYARIRPATLQIEHHPYLTQTRLVEYAQKEGLTVTAYSSFGPLSFLELSVQNAVDSPPLFEHQLVKSIAEKHGRTPAQVLLRWATQRGIAVIPKSNNPQRLKQNLDVTGWNLEEEEIKAISGLDRGLRFNDPLGYGLYAPIF
What is the function of this protein?
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol.  Xylose is a major component of hemicelluloses such as xylan.  Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
What are the official names of this protein?
Probable NAD(P)H-dependent D-xylose reductase xyl1, XR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: C96T3_NARAP
Sequence: MATSSSAWLIFSDHYPEILIAIACFLIFSLLLSARSSSEDSLPYNWPIFGMLPAIISNSQFNDFTTARLRKMGWTFIFKGPWLLDMDYIFTCDPSNINHMFNDNFENYPKGELGKVFDIFGNNIFNADGDLWHDHRKMAQTILWDGNYRTMQATFIRNKMDNALIPILDSAASKRKPVDLQDVFFRFTFDTSCFSVLAADPESLTMEFPAVPFSKAADQALDAALTRHITPRLIWKLKRFFNVGSERTLAVAWKVIDSYIYDKIAELKAKRKLVGKINSYDAVSFYMDNFNIHDDKFLRDNAFTYLLAQRNTQSLTMAWLFYALFENPKVELKILSELKSIVDESSERRFNDGFALFDSNMIQSAIYLHATLCEALRIYPPVPFEIKDAHKADVLPSGHKVRAGEKILFSPYAMARMKGIWGDDCLEFKPERWITGNGTLKHEPAYKFFAFSAGPRICLGKELSFTQMKMVVATIIYNFHLQMVKGHVVEQSNSILMDMKHGLMVQVRKRSVM
What is the function of this protein?
Cytochrome P450 that catalyzes an intramolecular para-para' C-C phenol coupling of 4'-O-methylnorbelladine in alkaloids biosynthesis, including haemanthamine- and crinamine-type alkaloids, promising anticancer agents.  Catalyzes the formation of (10bR,4aS)-noroxomaritidine and (10bS,4aR)-noroxomaritidine from 4'-O-methylnorbelladine.
What are the official names of this protein?
Noroxomaritidine synthase 3, CYP96T3, Cytochrome P450 96T3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: K2C4_BOVIN
Sequence: RLRSEIDHVKKQCASLQSAIADAEQRGELALKDARSKLADLEDALQKAKQDMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLSGEGVGQVNISVVQSTVSGGYGGAGGYGGASGLGSGLGVSGGSGYSYSSGHSLGGGFSSGSGRAIGCGFGSSGGSSSTIKYTTTTSSSSRKGYKH
What are the official names of this protein?
Keratin, type II cytoskeletal 59 kDa, component IV, Keratin K6-gamma.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: BETA_SHIF8
Sequence: MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALSRSTAGYFVANGMPVRAKK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: SCAM2_ORYSJ
Sequence: MAGRYDRNPFDEDDVNPFAGGSVPPASNSRMPPLPHEPGFYNDRGATVDIPLDSTKDMKKKEKELQAKEAELNKRESELRRREEAASRAGIVIEEKNWPPFFPIIHHDISNEIPIHLQRMQYLAFSSLLGLAACLFWNIIATTAAWIKGAGVMIWLLAIIYFISGVPGAYVLWYRPLYNAMRTESALKFGWFFLFYLIHILFCIWSAVAPPFPFKGKSLAGILPAIDVIGNNAIVGIFYFIGFGLFCLESLLSVVVIQQVYMYFRGSGKAAEMKREAARGAMRSAF
What is the function of this protein?
Probably involved in membrane trafficking.
What are the official names of this protein?
Secretory carrier-associated membrane protein 2, RiSC, Secretory carrier membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Protein: RHG31_HUMAN
Sequence: MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPPNQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTSPGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE
What is the function of this protein?
Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42.  Required for cell spreading, polarized lamellipodia formation and cell migration.
What are the official names of this protein?
Rho GTPase-activating protein 31, Cdc42 GTPase-activating protein.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Cell junction, focal adhesion.
Protein: TPIS_PSEA8
Sequence: MRRPLVAGNWKMHGTHSSVAELIKGLRQLALPSGVDVAVMPPCLFISQVIQGLAGKAIDVGAQNSAVEPMQGALTGETAPSQLADVGCSMVLVGHSERRLILGESDEVVSRKFAAAQSCGLVPVLCVGETRAEREAGKTLEVVARQLGSVIDELGVGAFARAVVAYEPVWAIGTGLTASPAQAQEVHAAIRAQLAAENAEVAKGVRLLYGGSVKAASAAELFGMPDIDGGLVGGASLNADEFGAICRAAGS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_STRM5
Sequence: MPEYRSRTSTAGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKVGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSEHKLDLVDAMVIAADESASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLIVELCHRWYGGEDPTALPRGIATQAAFANAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLTHIDALSRRVPQLCKVAPNTPKYHMEDVHRAGGVYGILGELARGGLLDTGVPTVHSRSLADAIARWDVAVSSDSSVQDFFRAGPAGISTQVAFSQATRWPTLDVDRAEGCIRSVKHAYSAEGGLAVLRGNLAVDGCVVKTAGVDESIHVFEGNARVYESQDAAVAGILADEVKAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHVSPEAASGGTIGLVEDGDRIRIDIPARRIDLLLDEATLAQRRADADARGWKPRAPRPRKVTSALKAYALLATSADKGAVRNTALLGD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ASSY_KORVE
Sequence: MREKIVLAYSGGLDTSIIIPWLKENYSCDVIAMVGDVGQGDDIDAVVAKAHKTGASKVIVKDLREEFLTQYVYPAISTGAVYEHKYLLGTSLARPPIAKAQVEVALAEGATAVSHGCTGKGNDQVRFEHAFQALAPELKIIAPWREWTLKSREDCLDYAEAHGISVAQSREKIHSRDRNLLHVSHEGGELEDPNNAPLDTTWTWTKSPQEAPDRVEEVTIGFEGGVPVSINGMKLEPLALIELLNEIGARNAIGRIDLVENRFVGIKSRGCYETPGGSLLLAAHRELEALCLDRDTLHYKQEVALKWAELVYFGLWFTPLRESLDAFVASTQKNIAGAVKLALYKGNIAVAGRTSPKSLYRPDIASFTMGAGYDQKDAEGFIRILGLPARSRALIENAGKEKVSK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_PSESM
Sequence: MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVFTNEGVLERRRRSGKVSELEQALAGEPLIGRLGIAHTRWATHGAPCERNAHPHFSADELAVVHNGIIENHEALREQLKSLGYVFVSDTDTEVIVHLLHHKLKDTPDLAVALKSAVKELHGAYGLAVINAAQPDRLLAARSGSPLVIGVGMGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWTVDGLPVVREVVQYHEGAEAADKGEYRHFMLKEIHEQPKVVQRTLEGRLGQHQVLVHAFGPQAAELFAKVRNVQIVACGTSYHAGMVARYWLEGLAGIPCQVEVASEFRYRKVVVQPDTLFVSISQSGETADTLAALRNAKELGFLASLAICNVGISSLVRESDLTLLTQAGPEIGVASTKAFTTQLVALLLLTLSLGQVKGSLEEGVEAQLVEELRRLPTRLGEALAMDGTIEKVAELFAEKHHTLFLGRGAQFPVAMEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVTVAPNNELLEKLKSNLQEVRARGGELIVFADEQAGMKNGEGTHVIAMPHIIDALAPILYTIPLQLLSYYVAVLKGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLHL6_HUMAN
Sequence: MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV
What is the function of this protein?
Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
What are the official names of this protein?
Kelch-like protein 6.
Protein: PYRD_YERE8
Sequence: MYYPLVKKALFQLDPERAHEFTFRQLKRLTGTPLQFLVSQSVPTKPVSCMGLSFKNPLGLAAGLDKDGECIDALGAMGFGFIEVGTVTPKPQSGNDKPRLFRIVEAEGLINRMGFNNHGVDNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMDKVYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKNKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNIDGVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIRRLSQELQGRLPIIGVGGIDSVTAAREKMAAGASLIQIYSGFIFRGPGLIKNIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: EDSP_CYNPY
Sequence: MNTITVYEHSNFQGLHKTFTSDVPNLVNESFNDCISSVKIVGQPWILHQDINYSGQCLPLEEGEYSGISMNDGASSLRLITDDLSNPQITVYEHVNGGGKALVLTEETNLAFGNMHDNISSHRVQRGAWALYEHINRGGRCIVARAGEYLANYCTIGFNDQVSHVYPLRAGKTSVTATILWDRKKVESERNVQIDQYFYTNNTSIEQQFTATSTKEFEKYVSHSFEFSNETSIKVGTSFTLKGVVDINTEVSNTFTVKKGETESFTTRKKAELSMPVKAPPRSKLTVNFMCKEITISVPVELKIVRGSKTDIETGTYRCESGTETYIDVQSLPIS
What are the official names of this protein?
Epidermal differentiation-specific protein.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: PA2B1_DABSI
Sequence: MRTLWIVAMCLIGVEGNLFQFARLIDAKQEAFSFFKYISYGCYCGWGGQGTPKDATDRCCFVHDCCYARVKGCNPKLVEYSYGYRTGKIVCENYNRCKRAVCECDRVAAICLGQNVNTYNKGYMFLSSYYCRQKSEQC
What is the function of this protein?
Exhibits high hydrolytic activities and shows strong preference for the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 DsM-b1/DsM-b1', svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PG094_VACCT
Sequence: MGGGVSVELPKRDPPPGVPTDEMLLNVDKMHDVIAPAKLLEYVHIGPLAKDKEDKVKKRYPEFRLVNTGPGGLSALLRQSYNGTAPNCCRTFNRTHYWKKDGKISDKYEEGAVLESCWPDVHDTGKCDVDLFDWCQGDTFDRNICHQWIGSAFNRSNRTVEGQQSLINLYNKMQTLCSKDASVPICESFLHHLRAHNTEDSKEMIDYILRQQSADFKQKYMRCSYPTRDKLEESLKYAEPRECWDPECSNANVNFLLTRNYNNLGLCNIVRCNTSVNNLQMDKTSSLRLSCGLSNSDKFSTVPVNRAKVVQHNIKHSFDLKLHLISLLSLLVIWILIVAI
What is the function of this protein?
Component of the entry fusion complex (EFC), which consists of 11 proteins.  During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.
What are the official names of this protein?
Entry-fusion complex protein OPG094, EFC protein OPG094, Myristoylated protein G9.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG086 family.
Protein: THIG_ZYMMO
Sequence: MSDDSWSVAGHTFKSRLIVGTGKYKDYAQNAAAVKAAGAEIVTVAVRRVNLTDTSAPMLTDYIDPKEYCFLPNTAGCFNAEEAVRTLRLAREAGGWTLVKLEVLGEARTLYPDMVETLKATEILVKEGFQPMVYCSDDPIMAKRLEDAGAVAIMPLGAPIGSGLGLQNPVMLRLIVEAANVPVLVDAGVGTASDAAVALELGCDAVLMNTAIAEAKNPVLMAQAMKSAVEAGRMAYLAGRMGKRMYADPSSPLAGLI
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUFP_POPTR
Sequence: MASILLSLNTHTLLPLHTRTRTTKTTLKILRFSHKLPPSSPFYCNHETRLHLRCQTTTGTPSAADFAAAAGQDRLRKVPIKNIRNFCIIAHIDHGKSTLADKLLQMTGTVQKREMKEQFLDNMDLERERGITIKLQAARMRYVYENEGYCLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKIDLPGAEPDRVCKEIEEVIGLDCSNAIHCSAKEGIGITEILNAIVERVPPPRDTAAMPLRALIFDSYYDPYRGVIVYFRVIDGNIKKGDRIYFMASEKDYYADEIGVLSPNQMQVEELYAGEVGYLSASIRSVADARVGDTITHYSRKAEQSLPGYEEATPMVFCGLFPVDADQFSELRDALEKLQLNDAALKFEPETSNAMGFGFRCGFLGLLHMEIVQERLEREYNLSLITTAPSVVYRVHCVDDDIVECSNPSLLPEPGKRRSVEEPFVKIELLTPKDYIGTLMELAQERRGEFKEMKYITENRASITYELPLAEMVGDFFDQLKSRSKGYASMEYTVVGYKESDLIRLDIQINGDPVEPLATIVHKDKAYSVGRALTQKLKELIPRQMFKVPIQACIGAKVIASESLSAIRKDVLAKCYGGDISRKKKLLKKQAAGKKRMKAIGKVDVPQEAFMAVLKLEKEVL
What is the function of this protein?
Promotes chloroplast protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
What are the official names of this protein?
Translation factor GUF1 homolog, chloroplastic, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DEF1_CANGA
Sequence: MSSVQNKVETLVELFPDWKREDLLELVQEEKDTELEIIVEKITTGKVTKWDEVKKPKRERHAPEASSVRTYSSSTHSHSAASGGAAAPRYKKSGRFAGNSGVSNTATGSSTSTSSGTSTSASSHGAAQSASSGKNATAAAQAAVKKTGVPAGTKEEKIAQRLNSTHTQEERKKMSWAAIATPKPKPKPVQKKKEEEPAQESQEDTKASESSKESALENVEDLKNEVDNIEKEQEKKEEPAQETEKETVEKEQEPQPQPQEQEQPQEQAQEQAANEQQQQEQQQPQQPQQEQQEQQLAQEAAAPAEAAPASKQGSVSEAAQQQQQQQQQQTAPQQTAQQQQPAQQLTDAQLQAQAQAQAQAQAQAQQYYMYQNQFPGYSYPGMYDMQGYAYGQQYQQPTPMGGHPAMVNAQFSMQQGYMNAGTPVSAGVDLNTATAAPNTAQSPVAPHTQQQSQQQPYGAGSFMPYYAHFYQQYPYGQPQYGVAANQYPYQTTKSSGQNLYGGEYGQQAQQDAQAKGVQRNDSHSEQQTSDSAQQQLTPQQIQLQQYYQYQQQQQQQQQQQQQQAPQQQQQPNAQQYGYSGYDYNTKSTNGFY
What is the function of this protein?
Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II.  Also involved in telomere length regulation.  Binds DNA.
What are the official names of this protein?
RNA polymerase II degradation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RL7_STRP1
Sequence: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAGGAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEAEEIKAKLEEAGATITLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CACB2_HUMAN
Sequence: MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
What is the function of this protein?
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity).  Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity).  May modulate G protein inhibition (By similarity).  May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916).  Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: ACHA9_HUMAN
Sequence: MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
What is the function of this protein?
Ionotropic receptor with a probable role in the modulation of auditory stimuli.  Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151).  The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151).  In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.  This may protect against acoustic trauma.  May also regulate keratinocyte adhesion (PubMed:11021840).
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: YE72_SCHPO
Sequence: MDVIQRIITLDRRSKGFYIITNDLVKKLPELKSFSSGTVNFFIQHTSAALTINENWDADTRADMNDILDKIVPESAGYRHTAEGLDDMPAHVKSSLIGPSLTVPITNGKLSLGTWQDIQLAEFRRQPHSRTIVCTIIGLRSN
What are the official names of this protein?
UPF0047 protein C4A8.02c.
What is the protein family that this protein belongs to?
Belongs to the UPF0047 family.
Protein: LVSF_DICDI
Sequence: MFSKNINKVRFNLTLMDEGEYYFDDYSAIFYPPSNTEEESWQKRIAGRILVCSSSMFFEPDDSKLPIMKFPYKDMSSIGAWLNSLSSAPPAHLPTPQPIPQSILSPSKPTPTPTPPIVVEQPSPTRSAFSRLLSFSSLTSKVTTPTPPTPTPTPPTPQPTSIAPTPTIATNPYTSFSVSPNPPSPLLSQLFEQAKPSFLASKGDIFYVKSSQVIEMKENSRNHPYIFKQYNNIDFKFSFNYVKQNIVLDVMKVFHNYSGKEKIQRDELIKQMVEDRENKIFFDITQLVDMNERNILELKCSKISPLVENPGRLLITNARLYFQPMNNIEENRLKNYSLQSIIRVLQRRHSLREIGLELFFDDGSSLFLKFNNTITRNQVYDLLVKHLCTNIMHINEQANYLLKWQNGIISNYDYLLYLNNLAGRTFNDLTQYPVFPWIIADYQSTTLDLNRNETFRDLSKPIGALNPTRLATFQDRYHQIPDDQPKFLYGTHYSTPAYVLYFLVRQVPEYMLRLQNGRFDSPNRMFYSIEETWNSVLNSTTDVKELIPEFYKPSFESSSSSRNGGGGDDDDNFENGIFLTNSENLPLGIRQDNNVINDIILPPWASSPKDFISKLHQALESEYVSQNLHHWIDLIFGYKQKGEEAVRANNLFYHLTYEGSIDIESITNPFEREGMEAQINEFGQTPRQIFKTPHPQRLPQQLRNQNLKIELSDLEQNINFIFDELNNCNINELNNDNDNNLNNNNNNNNNNNSNSNSNLNNNYIDSNINNNINNIENINSLNNENNENSNDKKNNSNSNSSDNIKNSNGFENNDNNFNNENENLNDENENLTFLGEERNNSNNWGSLNFLKFNQNIKLHKDKISALYLSNNSETIYSVSLDSCLKIYSLKEKRQIRSLNLCNLALSSFQLSKDEKYIIIGSWDNNIYVYSVGNGSISYSIPGHSDAVSCLKLHNNNILVSGSWDSSVKVWRTHRQSNGAISIEKTPIADFVDSDTEIRSIDISSNGTIFCAGSSDGYLYFYDLLTLQLIRRISCFFDELVCIKFTPDGSRIITACIDGSVKLIGIEGSEIFSFKVKGEIHCLDSDGSSLIIGTDRGLCLWSLTTGTEIKDSISPFLSQSSNESIHSLNVSINQSSNKPILLTGTEAGSISIWQQ
What are the official names of this protein?
BEACH domain-containing protein lvsF.
Protein: KRUP_LITFO
Sequence: MRLHTGEKPYHCTHCERQFVQVANLRRHLRVHTGERPYACELCTSK
What is the function of this protein?
Krueppel is a gap class segmentation protein.
What are the official names of this protein?
Protein krueppel.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.