PharMolix/UniProtQA huggingface dataset:
Protein: PILR4_THUPL
Sequence: MEESSRILVVGGTGYIGRRIVKASIALGHPTFILFRKEVVSDVEKVEMLLSFKKNGAKLLEASFDDHESLVDAVKQVDVVISAVAGNHMRHHILQQLKLVEAIKEAGNIKRFVPSEFGMDPGLMDHAMAPGNIVFIDKIKVREAIEAAAIPHTYISANIFAGYLVGGLAQLGRVMPPSDKVFLYGDGNVKAVWIDEEDVGIYTIKAIDDPRTLNKTVYIRPPLNVLSQKEVVEKWEKLSRKSLDKIYMSVEDFLAGMEGQSYGEKIGISHFYQMFYKGDLYNFEIGPNGVEASQLYPGVKYTTVDSYMERYL
What is the function of this protein?
Reductase involved in lignan biosynthesis.  Catalyzes the enantioselective sequential conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol.  Abstracts the 4R-hydride from the NADPH cofactor during catalysis (By similarity).
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase, PLR-TP4, (+)-lariciresinol reductase, (+)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SYFA_LACDA
Sequence: MDLFDRLKELREQGLAEIKEAESEKSLNDVRVKLVGKKGELTQILHQMKDVAPEKRREVGQKVNELRDLFNENLASAKDNLIEKAIEARLEAEKIDVTLPGRRKHVGSKHPIRIIQDDLERFFIGMGYQVVQGPEIESEHYNFEMLNLPKDHPARDMQATFYVDADHLLRSQTSPVQARTMEKHDFDKGDLKMISPGKVYRRDDDDATHSHQFMQMEGLVVGKNISLSDLKGTLELVAKHEFGQDRETRLRPSYFPFTEPSVEMDVSCFECGGKGCAICKNTGWIEVLGAGIVHPNVLSAAGIDPSVYSGFAFGLGLDRFAILKYGIDDIRDFYSDDVRFLQQFRQEED
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_RHOCS
Sequence: MSVRKRIGVYPGTFDPITNGHFDIIQRATLVVDHLIVGVARNAGKGPLFSTDERVEMVRDELPHISTHGATVEVRAFDSLLMHFAVEMGAQVIIRGLRAVSDFEYEFQMAGMNHRLNPQVETLFLMASDRHQFISSRFVKEIGRLGGDIRPFVSPRVAKRLLSRFAQEMPLPADTTLPLQAAP
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_THERP
Sequence: MSRLLPSTTNQHPTSPSFDSVVILDYGSQYAQLIARRVRDAHVYCELVPYDTDWSALKHLSPKGIILSGGPASVYEPDAPQLPSWVLESGLPVLGICYGMQLLAHTLGGRVAPAQRREYGPAVVERVADHPIFAGLPARFDVWMSHGDRIDALPPGFEVLARSANAPYAAMARDHLIGLQFHPEVAHTPLGSVILRNFLFDVCGCAPTWTAESFVEQAIREIRERVGKDRVLLALSGGVDSSVAAALIHRAIGDQLTPVFVDTGLLREGEAETIREVFGRHFRMPLVAIDARQRFLVRLRGVSDPEQKRRLIGEEFVRVFEEIARSQGPFRFLAQGTLYPDVIESAAPGASRTAAKIKTHHNVGGLPQDLEFELLEPLRYLFKDEVRAIGRLLGLPEEIVQRQPFPGPGLAVRILGEVTEEALAIVRRADTIVREEVEAAGLSDGLWQFFAVLLPVHSTGVMGDQRTYARVIAIRAVTSTDAMTADWARLPHDLLARLANRIVNEVPGVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PSUG_ROSS1
Sequence: MTLEHDRKGISIAVSAEVQAALDAGQPVVALESTVISHGLPYPHNLELALAMEQEVRDQGAVPATVGIVAGVPTVGMDAAAIRRFAHPDPHHPPLKVSRRDIGYVVAAGGDGATTVAATMALAHLAGVQVFATGGIGGVHRGARETWDVSADLTELERTPVLVVCAGAKAILDLPATLEYLETGGVPVLGWRTAEFPAFYSVSSGLPVAYAQDASFVARAWKAHRALGGAGMVLAVPPPVEDAIDRAVVEAAIERALNRAVKEGVHGPAVTPFLLAALARETEGESVRANVALLRQNARIAAQVATAIAGI
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: YCSE_STRTR
Sequence: MRKSFYTWLMAQRNPKSNEPVAILADLAFEDSTFPKHTDDFEEVSRYLEDHASFSFNLGQFDQIWEDYLAH
What are the official names of this protein?
UPF0346 protein in cse 5'region.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: METN_XANAC
Sequence: MIQFQRLHKSYSVDGRQIVALHPLDLRIGPGEVFGIIGHSGAGKSTLIRLINRLEEPSGGRLLIGEEDVTALDRQGLRALRRRIGMIFQHFNLLSSRTVAGNVAFPLELAGTPRAEIDARVAELLARVGLQEHANKYPAQLSGGQKQRVGIARALATRPQILLCDEATSALDPQTTASVLQLLAQINRELGLTIVLITHEMDVIRRVCDRVAVLDAGKLVETGPVTEVFLHPKHATTRRFVSEAEHVDEAELHRDFAAVGGRIVRLTFLGNGTYEPVLGRIARETGVDYNILSGRVDRIKDTPYGQLIVALTGGDHNAARAGFVAAGVQVEELRV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PRIO_SYMSY
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSSQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: RS18_SYNC1
Sequence: MAERTTSGTPAKRSVRRRFSRRKGCRFCADNTLKIDYKEIRNLRYFITERGKIVPRRISGNCAEHQRKIREAIKRARNIALLPFTAGHSLD
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NU6C_DRIGR
Sequence: MDLPGPIHDILLVFLGSGLILGGLGVVLFTNPIFSAFSLGLVLVCISLFHILSNSYFVAAAQLLIYVGAVNVLIIFAVMFMNGSEYYNDFYLWTVGDGVTSLVCTSILFSLITTISDTSWYGIIWTTGSNQIIEQDLISNVQQIGIHLSTDFYLPFELISIILLVALIGAIAMARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: EIN4_ARATH
Sequence: MLRSLGLGLLLFALLALVSGDNDYVSCNCDDEGFLSVHTILECQRVSDLLIAIAYFSIPLELLYFISFSNVPFKWVLVQFIAFIVLCGMTHLLNAWTYYGPHSFQLMLWLTIFKFLTALVSCATAITLLTLIPLLLKWKVRELYLKQNVLELNEEVGLMKRQKEMSVQVRMLTREIRKSLDKHMILRTTLVELSKILDLQNSAVWMPNENRTEMHLTHELRANPMRSFRVIPINDPDVVQVRETKVVTILRKNSVLAVESSGCGGSEEFGPVAAIRMPMLHGLNFKGGTPEFVDTPYAIMVLVLPSANSRVWTDKEIEIAEVVADQVAVAISHASVLEESQLMREKLGIQNRALLRAKQNAMMASQARNTCQKVMSHGMRRPMHTILGLLSMFQSESMSLDQKIIVDALMKTSTVLSALINDVIDISPKDNGKSALEVKRFQLHSLIREAACVAKCLSVYKGYGFEMDVQTRLPNLVVGDEKRTFQLVMYMLGYILDMTDGGKTVTFRVICEGTGTSQDKSKRETGMWKSHMSDDSLGVKFEVEINEIQNPPLDGSAMAMRHIPNRRYHSNGIKEGLSLGMCRKLAQMMQGNIWISPKSHGQTQSMQLVLRFQTRPSIRRSILAGNAPELQHPNSNSILRGLRITLADDDDVNRTVTKRLLEKLGCEVTAVSSGFECLNALSNVEMSYRVVILDLQMPEMDGFEVAMKIRKFCGHHWPLIIALTASTEDHVRERCLQMGMNGMIQKPVLLHVMASELRRALQTASE
What is the function of this protein?
Ethylene receptor related to bacterial two-component regulators.  Acts as a redundant negative regulator of ethylene signaling.
What are the official names of this protein?
Protein EIN4, AtEIN4, Protein ETHYLENE INSENSITIVE 4.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DNAJ_TROWT
Sequence: MEDLYGILGVDHNASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQRYDRHVSGGFSSDFNLSDLFQSFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLVVCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLITQNTCSKCRGNGERIDHPCRRCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDGQDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDLCIVLNVLLMQKLDPEHRALLKKIMPNPPKPKLAKRTSGFFSWLKNKFT
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_METTH
Sequence: MSEPSSKELFEFKRTLQELSDKRGRGTELVSVYIPPDRQISDVAKHMREELSQSANIKSKQTKKNVQSAIEVIMQRLKLFPKPPEKGLVMFVGMVPRGGPGTEKMETYVFEPPEPIKTYIYHCNSEFYLEPLREMLEEKETYGLAVLDRKEATIATLKGKRIDILKTLTSGVPGKHKAGGQSQRRFDRLIDLAAHEFLKRIGEHMNEAFLQIDDLKGIILGGPGHTKEEFLNGDYLHHELKKKVITTVDTSYTGEFGIREVIDKSMDVLSEIDVMREKKLVQRFLRELINEDGLASYGEREVRQHLQMGAVEVLLLSEDLKYQRGTYECASCGHRMEKTGRDLPDTETCPSCNDQMRLSDRRDMIDDLVEMAEEVGTEVEIISTETEEGMQLLRAFGGIGAILRYRP
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1, Translation termination factor aRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_STRP3
Sequence: MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGMIIPVVISVYEDKSFDFITKTPPAAVLLKKAAGVEKGSGTPNTTKVATVTRAQVQEIAETKMPDLNAANIEAAMRMIEGTARSMGFTVTD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GATC_STRPG
Sequence: MKISEEEVRHVAKLSKLSFSESETTTFATTLSKIVDMVELLNEVDTEGVAITTTMADKKNVMRQDVAEEGTDRALLFKNVPEKENHFIKVPAILDDGGDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: METE_BORPE
Sequence: MTIIHNLGFPRIGAQRELKRAVEAYWAGRQTAEALHETGRALRAAHWQRQADAGVAFVPVGDFAWYDHILEWTTLLGAVPARFGHPEGKPVDLDTLFRMGRGRAPSGKPAAACEMTKWFDTNYHYIVPELTPGQTFRVAREDLFEQVKEAQALGHRVKPVIPGPLTWLWLGKGDAFAQGAGDIGKLQLLDALLPVYGEVLERLAGLGVEWVQIDEPALVLDLPQAWRDAYQAVYAKLAASPVKLLLATYFDGLKDNLATALALPVAGLHVDLVRAPDQLSDVASGLRPGQVLSAGVINGRNIWRTDLDAALAMLVPVREQLQERLWLAPSCSLLHVPVDLAGETELDAELLGWLSFAVQKLDELCLLGKALGGDADPAVQQGLAAQRAALQARRQSPRIHNPAVAQRMAGQAGVSRERAPFGQRIARQQSELRLPAFPTTTIGSFPQTAEIRALRRDWKSGALTDSAYENAIRKEIEEVIRFQEKVGLDVLVHGEPERNDMVEYFGELLAGFAFTKNGWVQSYGSRCVKPPIIFGDVARPAPMTVGWSAYAQSLTDKPVKGMLTGPVTILQWSFVRDDQPREATCRQLALALRDEVVDLEAAGIRVIQIDEPAIREGLPLRRADWRAYLDWAVDCFRLSTAGVGEATQIHTHMCYSEFNDIIESIAAMDADVITIETSRSNMELLKAFEDFHYPNDIGPGVYDIHSPNVPEVDWMVELMRKAAARLPKERLWVNPDCGLKTRAWPETEAALIGMVQAARTLRAA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MEND_SALAR
Sequence: MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKASKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGIFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRRESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTPQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELELALASAWRTPATTLIELVVNETDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: DNLJ_SHIDS
Sequence: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTILAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGSELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLVFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDSREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDEAEMLRLLGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RF1_CHLAA
Sequence: MFDKLAAVAARYDELTELMAQPEVATNVTLLQQYAREQREIEDIVNAYREYQATQRAIEEAEAMLEDSDPELRALAQEELETQRKRLASLEEQLKLLLLPRDPNDSKDVIMEIRQGEGGDEAALFAADLFRMYTRFAESRGWKVEVDSLTENGIGGIKEVIFQIHGEGAYSQLKYEGGVHRVQRVPATEARGRIHTSTATVAVLPEVEETEIEIKPEDLRIDVFRSAGHGGQGVNTTDSAVRIVYKPGTPEEIVVTCQDGRSQIQNRERAMTVLRARLYAREQEKRQREIGASRLAQVGSGERAEKIRTYNFPQDRITDHRIGQNFSNLPAVLDGELDKIIEALIIYDNAERLRASGVST
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_DESVH
Sequence: MSRDTTTPDDAAAFEAAATTSGTATSAGENIPGDLLPLCREHICPVCPEKAQADEQRLRALADLENTKKRLQREKDEQVRYAAETVLADLLPTLDNLDLALQYGQGSAECRNMLVGVEMTRKLLLEALGRHGLEAVGEAGEPFTPELHEAMSHEDRGDMPADHVATVMMKGYRLKERLLRPAKVTVSRTPG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRD_NEIM0
Sequence: MADMKRLKHLMFSPFIDNNPIALQVLGICSALAVTTKLQTAIVMGISVALVTGFSSFFISLVRNYIPNSIRIIVQMAIIASLVTLVDQLLQAFAYELSKQLSVFVGLIITNCIVMGRAEAFAMKEPPLESLIDGIGNGAGYGIMLLVVATVRELIGSGKLLGYTVFQTVQDGGWYQTNGLFLLAPSAFFIIGFLIWGLRTWKPEQAEE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TCAA_STAA2
Sequence: MKSCPKCGQQAQDDVQICTQCGHKFDSRQALYRKSTDEDIQTNNIKMRKMVPWAIVFFILILIIILFFLLRNFNSPEAQTKILVNAIENNDKQKVATLLSTKDNKVDSEEAKVYINYIKDEVGLKQFVSDLKNTVHKLNKSKTSVASYIQTRSGQNILRVSKNGTRYIFFDNMSFTAPTKQPIVKPKEKTKYEFKSGGKKKMVIAEANKVTPIGNFIPGTYRIPAMKSTENGDFAGYLKFDFRQSNSETVDVTEDFEEANITVTLKGDTKLNDSSKKVTINDREMAFSSSKTYGPYPQNKDITISASGKAKGKTFTTQTKTIKASDLKYNTEITLNFDSEDIEDYVEKKEKEENSLKNKLIEFFAGYSLANNAAFNQSDFDFVSSYIKKGSSFYDDVKKRVSKGSLMMISSPQIIDAEKHGDKITATVRLINENGKQVDKEYELEQGSQDRLQLIKTSEK
What is the function of this protein?
Plays a major role in decreasing resistance to glycopeptide antibiotics.
What are the official names of this protein?
Membrane-associated protein TcaA.
What is the protein family that this protein belongs to?
Belongs to the TcaA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ILVD_TRIEI
Sequence: MPENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMRAVSGVKEAGGMPQIFGTITISDGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAIGGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLTVVSAFEAVGEYSAGKIDETELTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLVEAIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRARVPVLCDLKPSGKYVTTNLHQAGGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEPPSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKNPEITGLARVFDSEEACLEAILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMVVGHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVLAKYAKLVSSSSVGAVTDAGLG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ZNHI3_PANTR
Sequence: LEKPKYRCPACRVPYCSVACFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES
What are the official names of this protein?
Zinc finger HIT domain-containing protein 3, Thyroid hormone receptor interactor 3, Thyroid receptor-interacting protein 3, TR-interacting protein 3, TRIP-3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VMP1_DICDI
Sequence: MGKSNTIVLSNEKDIQLRIQQLEERKEKRKNVKLLFSPIKTTKYFLYILKDTLVSGIRYFQTRPFLLFFIALFASLTFIAVYVPGEHQKYMGKYSDLISDCIWWVGLGVLSSIGLGTGLHTFVLYLGPHIAKVTLAATEWNSVNFNVYGANSFIQPATAMIGGVSFWMILQKVQWAALFWGAGTAIGELPPYFVARTARLKGLKLEQEKKLKEQQEKPIDEKDQPKKGLLERLSEKVPALIGNLGFFGILAFASIPNPLFDLAGITCGHFLVPFWKFFGATFIGKAVVKAHIQACFVILAFNMETLTMVISFIEDKIPFLKNKIQPILEKERQKLNSTVSANSPKSLVGLAWDCVLFLMISYFLMSIVDSSVQEYLIEKDNKKIELLKSKLEKQQPKETKKTK
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity).  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted (By similarity).  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:18550798).
What are the official names of this protein?
Vacuole membrane protein 1 homolog, Transmembrane protein 49 homolog.
What is the protein family that this protein belongs to?
Belongs to the VMP1 family.
Protein: IRAM_ECO27
Sequence: MKWIVIDTVIQPSCGISFSVIWSKIKLIIWYQSDAFLPPESIFTLTHTGIMLNNKVLPVTIYNVVPFNKTFWNLIKNSQECPTNTDNVLNECFNNRCTLQICPYGLKQQSP
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.