PharMolix/UniProtQA huggingface dataset:
Protein: PIPS_CUTAK
Sequence: MLEHFRAGWAKVMNPIADALLRAHVTPDVVTWIGTIGAVLMALICFPQGWLWQGPWLVTLFIFSDSLDGNMARKLGRHSQWGSFLDSTLDRFGDAAIFTGVALYFAGPGNSVLWTAMACAALVFGMATSYVRAKAESLALEAKVGIATRADRLLVSLVAIEITGLARVGAFPHWCVVALPIALCYLTLAGAITVVQRMVAVRRACES
What is the function of this protein?
Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP.  PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
What are the official names of this protein?
Phosphatidylinositol phosphate synthase, PIP synthase, CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DSBB_XANOR
Sequence: MNPFRWSFRAQFLLGFLACAGLLAYAIYVQLHLGLEPCPLCIFQRIAFAALAVFFLIGALHGPRAAGARKVYGVLSFIAAGVGMGIGARHVWVQIRPKDMMSSCGPPLSFLSETMGPFEVFRTVLTGTGDCGNIDWRFLGLSMPMWSMVWFVGLALWALSAGFKARRSSLHH
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZSCA4_HUMAN
Sequence: MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKASVKEKWKSSGKNLERFIEDLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQVNAQTTREANMGTPSQTSQDTSLETGQGYEDEQDGWNSSSKTTRVNENITNQGNQIVSLIIIQEENGPRPEEGGVSSDNPYNSKRAELVTARSQEGSINGITFQGVPMVMGAGCISQPEQSSPESALTHQSNEGNSTCEVHQKGSHGVQKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSMCKKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEKITLPSVPSTPEAS
What is the function of this protein?
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency.  Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation.  Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
What are the official names of this protein?
Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: PSBT_LEOCS
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MKLN1_RAT
Sequence: MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKENLSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL
What is the function of this protein?
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity).  Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (PubMed:25579817).  Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity).
What are the official names of this protein?
Muskelin.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Synapse. Postsynapse. Note=Colocalizes with GABRA1 at synapses and in postsynaptic regions. Colocalizes with actin fibers in the cell cortex.
Protein: Y764_XYLFA
Sequence: MTIQSLIVTIGSGGLVGFALGLLGGGGSILATPLLLYVVGVTNPHIAIGTSAVAVSANAYANLIAHAWKGHVWWRSAVIFALVGTLGAFLGSSIGMLIDGQRLLLLFGLLMAMVGLLMLRGRATAPHAEQHQTVLRMCMKTSAVAILTGAASGFFGIGGGFLIVPALIFATRMPTINAIGSSLLAVGTFGLITTLNYARHDLVDWTIAMEFIVGGITGGGLGTLLATRFSASKHLLNRVFGLIVIAVAIYVIWRSWASLVA
What are the official names of this protein?
Probable membrane transporter protein XF_0764.
What is the protein family that this protein belongs to?
Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HISZ_THEMA
Sequence: MDFLDFEKVFSFYSKATKKGFSPFFVPALEKAEEPAGNFFLDRKGNLFSIREDFTKTVLNHRKRYSPDSQIKVWYADFVYRYSGSDLVAEYQLGLEKVPRNSLDDSLEVLEIIVESASEFFEGPVIVEIGHTGVYEDLLKEIPKDLHEKVLNLIDTKNLAEIEFLSHMKKIDLSRVEKIIEDSIYRRSPEHLKTMDLPLSVREDLLSASSFLQEKFPTVSVEIDLTLARTIEEYCGLIFTIYDTSSSRLVAAGGEYTVNGEKGVGGSIFLEGKTC
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAKAI_ARATH
Sequence: MLQIRLRRDSPTETGNGARPSPTETVTVACPDHLVLADLPVAKGIGSVTPTTVIKPVGRRSRRQLGERVHFCVRCDFPIAIYGRLIPCDHAFCLECARSDSICYLCDERIQKIQTIKMMEGIFICAAPHCLRSFLKKLDFEAHVHDLHGSLLQADAEKEDGNQSDVQSTMQQSSASESTLRAPLRSQLQQSRELNRSASFAKSQSGFSQVQNYPPDSDNSRPPGFETASPKPGIRFPDYPQPMNLMQPPSLPVPMNQNPGLPQQFGFPSYPTTESGSSQQFFNGAQYEMTRTESGGSEQSSLLGYPPPSPMTNLNFQGSYPPPSWNPGMAPPHTTQQVNRGRDGQSFGWPQENRDGFGQE
What is the function of this protein?
Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:28503769).  Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769).  N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:28503769).
What are the official names of this protein?
E3 ubiquitin-protein ligase HAKAI homolog, RING-type E3 ubiquitin transferase HAKAI.
What is the protein family that this protein belongs to?
Belongs to the Hakai family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm.
Protein: PDXB_PSEFS
Sequence: MLIVADENIPLLDAFFQGFGEIRRVPGRSLDRATVEQADVLLVRSVTNVNRALLEGSKVRFVGTCTIGTDHLDLDYFKQAGIQWSSAPGCNARGVVDYVLGSLQTLAEIEGADLNQRTYGVVGAGEVGGRLVKVLKGLGWNVLVCDPPRQIAEDGDYVSLAQIIEQCDVISLHTPLTKSGNGSTWHLFDRQRLEQLKPGTWLINASRGPVVDNAALREVLLAREDLQAVLDVWEGEPEVDVDLADLCVLATPHIAGYSLEGRQRGTAQIYQAFCAHLGQAPSILLSDLLPPPWLAEVHLNASTDPAWALATLCRSVYDPRRDDADFRRSLVGTVEEQRKAFDLLRKHYPARREIEGLKVRINGESTALASIVSALGAQAI
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_ZYMMO
Sequence: MPKRVLTGTVVSDKTDKTVVVLVERKVKHPLYGKIIRLSKKYHAHDEQNAYHEGETVRIEECAPISKLKSWRVLEKADKASAA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL20_BUCA5
Sequence: MARIKRGVVAHARHKKILKQAKGYYGARSRIYRVAHQAVIKAGQYAYRDRRQRKRQFRQLWISRINAAVRQSKMSYSNFIFGLKKASINIDRKILSDIAIFDLLSFNALVKKAKEALL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: COAX_MYCSK
Sequence: MLLAIDVRNTHTTVGLISGSGDHAKVVQQWRIRTESEATADELALTIDGLIGEDSERLTGAVGLSTVPSVLHEVRLMLEQYWPSVPHVMIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYHRFGTAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELTRPRSVIGKNTVECMQSGALFGFAGLVDGLVNRIREDVAGFSGTDVAVVATGHTAPLVLPDVHTVAHYDRHLTLDGLRLVFERNRDGQRGRR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S4A11_MOUSE
Sequence: MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP
What is the function of this protein?
Multifunctional transporter with an impact in cell morphology and differentiation (PubMed:20185830).  In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (By similarity).  At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (PubMed:33247189).  In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance.  Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species.  In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor.  In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity).
What are the official names of this protein?
Solute carrier family 4 member 11, Sodium borate cotransporter 1, NaBC1.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: SLYX_VIBC1
Sequence: MTDKIIQQLEARINDLECQLAFQEQTIEDLNGALSQQQLQITKMLDQMKYVVGKVKNMDSSNLADPSEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: SAT_NOSP7
Sequence: MSHNPDAIAPHGGQLVNRIATPEQREEFLSKADFLPRVQLDDRAVSDVEMIAIGAFSPLTGFMSQEDYDRTVTEMRLANGLVWSIPITLSVTEEVASPLQEGGLIRLDNSRGEFIAVLQLTQKYNYDKTREAINVYRTDDVKHPGVQVLYSQGTVHLAGDIWLLQREPHPQFPTYQIDPSASRQLFKDKGWKTIVGFQTRNPIHRAHEYIQKCALEIVDGLFLHPLVGATKEDDIAADVRMRCYEILLEHYYPLDRVTLAINPAAMRYAGPREAIFHALVRKNYGCTHFIVGRDHAGVGDYYGTYDAQYIFDEFAPGELGIVPMKFEHAFYCTRTKQMATSKTSPSRPEERIHLSGTKVREMLRRGELPPPEFSRPEVAAELARAMRIEVPV
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: NODI_BURO1
Sequence: MSVAPIDFRNVEKRYGDKLVVNGLSFSVKVGECYGLLGPNGAGKTTTLKMLLGLAHPDAGTISLCGEPVPSRARHARQRVGVVPQFDNLDPDFTVRENLLVFSRYFGMSAQAARALVAPLLEFAKLENKADAKVGELSGGMKRRLTLARALVNDPDVLVLDEPTTGLDPQARHLMWERLRSLLARGKTILITTHFMEEAERLCDRLCVIEEGRKIAEGAPHALIESEIGCDVIEIYGPDPAALRDELSAFAKHTEISGETLFCYVIDPEPLTARLKGRPGLRYLHRPANLEDVFLRLTGREMQD
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit is responsible for energy coupling to the transport system.
What are the official names of this protein?
Nod factor export ATP-binding protein I, Nodulation ATP-binding protein I.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.
Protein: VEMP_CVRSD
Sequence: MFNLFLIDTVWYVGQIIFIVAVCLMVTIIVVAFLASIKLCIQLCGLCNTLLLSPSIYVYNRSKQLYKYYNEEVRPPPLEVDDIIIQTL
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: NIKR_SACS2
Sequence: MSAEKISISLPKELYRELEDFIIRKGIPDRSKIFQIALRNYLDENRDGNEIIYGIINLVYDHEEASEALTEIQHEYNDSIISTLHLHVSEKICIEAIAVKGEKRKLVELNNKLGQIRGILKARLLISFPYEKT
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: PGSA_ECOL5
Sequence: MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARADLLDQ
What is the function of this protein?
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUS3_ASPFU
Sequence: MEPTTQTDPMTVTPKHELENGAAVAANDEEHPSKKQRLESISITEQEVSDGAPKRIKGVAPIKAEFLVQKSARSQPVEESALSLSADDAAEAAHYQEREGDQKGKKKASGQNKGRDFGRSEDAKGLCPSRAFSPEFSPKECKFGEKCRFEHDVRTYLKEHKREDLTTFGGICPIWDAKGRCPYGFKCRLVGSHMTERDTSDGRKELILLEDEERKKKARPVVPYASEDGLVNIVSNEDKIAVARRKTTTPRSDVYLAWLDKMSKALEKNLHGRHLEEGGADEGARAQTNDQVEENRAAYVEPPFLPSEKRRIYFGPETPTLAPLTTQGNLPFRRLCIDYGCQFTYSEMAMGMSLIQGQKSEWALMKAHESEALPPTISSTADVVQGYDNSKDFKFGAQIAGNKPWHAIKATELLSRLTPNLRVIDLNCGCPIDQVFREGAGSALLDHPSKLEKMLRGMNAVSEMIPITVKIRTGTRDNSPNATKLIERLVLGGHESGILNIGPPGVAAVTLHGRSRQQRYTKMADWSYIAECAALIKRLNEKKDDVTDTVREPDERMLPNGGKVFFLGNGDCYSHYDYDDHINNAGVDAVMVGRGAIIKPWVFEEIQAGQYLDKSATERLAMIEKYAKYGLDTWGSDEHGVGTTRRFMLEWLSFTYRYVPIGLLEYLPPHIQDRPPAWRGRNELETLLGSPNYKDWIKITEMFLGPAHKDFKFEPKHKSNAYEPQG
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase dus3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PP2C1_YEAST
Sequence: MSNHSEILERPETPYDITYRVGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVFL
What is the function of this protein?
It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1.  It is essential for growth or germination at 37 degrees Celsius.  May have a role in the heat shock response.  Involved in tRNA splicing and cell separation.
What are the official names of this protein?
Protein phosphatase 2C homolog 1, PP2C-1.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: MUTL_SHIDS
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHCDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNTQPGYQKQQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPAAERWLRQAQLTPGEAPVCAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: Y476_HAEIN
Sequence: MVIKCIDKQQNLGNIILFLLLKQQYSKEDSKKFTIYKFYLQTVNYTIQLS
What are the official names of this protein?
Uncharacterized protein HI_0476.
Protein: OMP5_HAEIN
Sequence: MKKTAIALVVAGLAAASVAQAAPQENTFYAGVKAGQASFHDGLRALAREYKVGYHRNSFTYGVFGGYQILNQNNLGLAVELGYDDFGRAKGREKGKTVVKHTNHGTHLSLKGSYEVLEGLDVYGKAGVALVRSDYKLYNENSSTLKKLGEHHRARASGLFAVGAEYAVLPELAVRLEYQWLTRVGKYRPQDKPNTALNYNPWIGSINAGISYRFGQGAAPVVAAPEVVSKTFSLNSDVTFAFGKANLKPQAQATLDSIYGEMSQVKSAKVAVAGYTDRIGSDAFNVKLSQERADSVANYFVAKGVAADAISATGYGKANPVTGATCDQVKGRKALIACFAPDRRVEIAVNGTK
What is the function of this protein?
Reconstitution in planar bilayers with lithium dodecyl sulfate-solublized P5 yields narrow pores (58 pS conductance) with a low probability of opening, whereas n-octyl-bD-glucopyranoside-solubilized P5 forms large pores (1. 1 nS conductance) with high open probability.  The large pore easily converts to the smaller pore at room temperature; at 42 degrees Celsius the smaller pore converts to the larger one.
What are the official names of this protein?
Outer membrane protein P5, OMP P5, Outer membrane porin A, Outer membrane protein OmpA, Outer membrane protein d.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: CLPP_SOLM1
Sequence: MATIPIVIETTGRTERAYDIYSRLLRDRIILLGSAVDDYVANLICAQLLFLESEDPEKEIFMYINSPGGVVSAGLAIYDTMQYVMPPVSTLCLGQAASMGALLLCAGATGMRYALPHSRIMIHQPSGGYQGQATDIEIHAKETRRTRETLNEIMAKHTGQSMERIQVDTERDNFMSAEEAVAYGLIDKVLTSRERLEKKDAE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_RHOPA
Sequence: MMNIHSVKGQKIAAGERTQEVDHPHSLVAQFGADQPLPLDCGIELSPFQIAYQTYGTLNADKSNAILVCHALTMDQHIANVHPITGKPGGWLTLVGPGKPIDTDRYFVICSNVIGGCMGSTGPASINPATGKAWGLDFPVITIPDMVRAQAMLIDRFGIDKLFCVVGGSMGGMQVLQWSVAFPERVFSALAIACATRHSAQNIAFHELGRQAVMADPDWQHGRYFEHGCFPHRGLAVARMAAHITYLSDAALHRKFGRKMQDRELPTFSFDADFQVESYLRYQGSSFVERFDANSYLYLTRAMDYFDIAADHDGVLAAAFRGTQTRFCVVSFTSDWLFPTSESRAIVHALNAGGARVSFAEIVTDKGHDAFLLDEPEFIDIARAFLQSAGTARGLGKAEH
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_METAC
Sequence: MEGNEKAEQKNATSEESTDIFENPGEGLEKATFAAGCFWGIEEAFRQVKGVVATAVGYSGGHFEKPTYEQVCTLDTGHAEAVRVIFDPKVVSYKNLLDVFWKIHDPTTKNRQGPDVGKQYRSVIFYHNEEQKAAALASKEELEKAGVFKNPIVTEIVPVSEFYMAEDYHQQYFEKKGFLQNILRSFKK
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: FRMD1_HUMAN
Sequence: MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTLGMDAMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV
What are the official names of this protein?
FERM domain-containing protein 1.