PharMolix/UniProtQA huggingface dataset:
Protein: SPT6_USTMA
Sequence: MADEERVPAPYFQDDEEGGASDEGEGVDLIKSHGNLVGSGGEDSSDEEEDDDPEEARRVAEGFIAEDDEEEEEDSEARRDRRRRRKKKRKQNEQDFEVDEDDLELLAENTGQPRRKEAGRLKRFRRGSASPPADDEAAARQRTLDQIFEDDDEDEDDIRSGRRGVNYDDDDEDLPSVGQALRAGVARKQREVVGAYEDDGLDDFIEEDEDDEEMQGLDEEEREARRQQRREEKRKARLSGSAADPAKAGIDHEAWDEIHEIFGNGEDYFWALEDEEEDAFDEEKKNKMEYKDIFEPAQIAERMLTEDDERIKRIDIPERLQLACPGEEGLKLLERKLTDTELFEAAKWASTRISQRTAAEFLDEAGLFHRQRSEFINAVQLMLSYMLNDLLEVPFLFQHRFDELEHLTFDEVERQYRSIDLLTRRELYTLSGLGLKFKTLLVRKDQLRATFNKIHVDVKTEPIQDDELDGGLDAMPADESRAARVESSQRQRAIFEDMLAQAASLEEISDITEYLTLRYGQQMRDAQALTSNGTDQAASDLQGLTLTSDPLVSATPAFKKPSLVGQYERNKKTVLAELAKKFGITSDELASNVTSHTRQYSPRDPEESPFKFAEQFTGSAWGAHSPEIALAKAKMMLSQEIGKDPILKREMRQLFKDAAEINIEPTERGMTVIDDQHPYANFKFIANKPARLVPQNPSQYLQMLQAEDELLIKLDIDLKDVVLTRFEARLYNNYASEGVGELSNAWNEQRRDVIREALKTHLVPNGRIWLKEFLREESRETLLRHVDVLMTKRVQEGPFMSKSMMARNRDPKIEEEDRIPRVLAVSHGGGDPRKDVVQAVYLDERGRFREHATFDDLRPLSARQMQERELELERTRGKAEFVDHRADFVKLLKQRRPDIVVVSGWSVRTAELKRHVQELADTAHQEICDADRLHSDLERDQAVIDVVTCHDDVARIYQHSSRAAEEFPELSELGRYCLALARYAQSPVNEFAALGSDLTAVILDPNQRLLPQDRLRLHFERCIGAVVNENGVEINQAMTSTYLQTMLPFVAGLGPRKAHALVNAISTKLEGTLINRTLLISRNILTFQVFQNCASFLRIEQDMLLEADEDDVPDVLDSTRIHPEDYDFPRKMAADALNKHEEDLEGEHPSLPCKELMEDADPADKLNTLDLDNYATMLFERKGERKRATLHSCRTELIKPYDDLREKQSEPSLEEMLTMFTGETSKTLAEGFVVSVEVTRVQEGNRMQEGHIKCRLDSGIEGTIEAEHAVEHYTPGSVRLRDLVRPQQTLDALVRKIDYKMCTVQLSISPWELQHRATHQGKTPIDIKFYDRRKADQWNEHAAAKAKLRIQARRQNRVIDHPNYHNFNYKAAVTFLRSQPRGTVVVRPSSKGDDHLAVTWKVDDDVYQNIDVTELDKESEYSLGRVLRIEGMGSYSDLDELIVNHVKPMVHMVEMMMNHEKYKGADEEDLHRFLTNWSLANPSRSVYAFGLNKDRPGYFNLSFKANRDAAIQTWPVKVLPNAFKLGPADQLADVAALCNAFKTQYTTQASMARGAKTPYGGGRTPAPGMGGATPLGGRTPYGGVRNGMAGSATPGQGVAGGYTTPMINVASATPNPYGGAYGRNGAAGGYGAPAAGGPPGRPPSMPGAPPMMPPGMASGGGAPSYAPPFAGAGEPGPPPARPPVPHGMHPDRFAQAEYGGASQQSYGENSGGAGGYGGGYRGY
What is the function of this protein?
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters.  Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT6, Chromatin elongation factor SPT6.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATSE4_PSEAE
Sequence: MSNVQNASRSSAFAAVEGDHWVESLDDGRHVLIRPLREEDRERERQFINRLSPATRHFRFLGEIKEASPALLDQLMDIDYQQSMAFVALVHEDGELREVGISRYAACCEEGQCECAVTIADDYQGLGLDAVLMRHLIDVARRNGFRQMYSVDSAANRAMRDLCCALGFVGQRDPDDSTQVIHRLAL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product.  It prefers the antibiotic chloramphenicol.
What are the official names of this protein?
Acetyltransferase PA5475, GCN5-related N-acetyltransferase, GNAT.
Protein: NADE_BUCA5
Sequence: MTLQKKIIELLGVKPAIIPEIEIKNCVDFLKKYLVNHVHIKSLIVGVSGGQDSTLTAKLCQMTAETLRKEKNDITYQFIALRLPYGIQYDEKDCQDAIRFIQPDQIFNVNIKKAVLSSEKSLKKSGVIISDYVRGNEKARERMKVQYSIAAMKQGLVVGTGHAAENITGFFTKYGDSGTDINPIAKLNKRQIRLLLKNLNCPKHLYLKKPMADLEDEHPQQDDESVLGVTYDAIDSYLEQKKIDIRSQKIIEALYLNTLHKRNLPITQ
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: EFG_BACC7
Sequence: MAREFSLENTRNIGIMAHIDAGKTTATERILYYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTIHDRLQANAHPIQLPIGAEDEFNGIIDLVEECAYMYGNDLGTDIQRVEIPEEHKELAEEYRGKLIEAVAELDEEMMMKYLEGEEITVEELKAGIRKATTSVEFFPVICGSAFKNKGVQILLDAVIDYLPSPLDVPAIKGTLPDTDEEVERKSSDEEPFSALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKSLVILESMEFPEPVISVAIEPKSKADQDKMGTALSKLSEEDPTFRAHTDQETGQTIIAGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRSAAKVEGKFARQSGGRGQFGHVWIEFEPNEEGKGFEFENKIVGGVVPREYIPAVGAGLEDALKNGVLAGYPVVDIKAALVDGSYHDVDSSEMAFKIAASMALKAAVSKCNPVILEPMMKVEVVIPEEYMGDIMGDVTSRRGRVEGMEARGNAQVVRAMVPLSEMFGYATSLRSNTQGRGTFSMVFDHYEEVPKSVSEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTRA_SYNY3
Sequence: MSAQAVFPIAPHRADFFPRFVLSNSSANKCHQAMKDVSLHSPKQTPSKISLAYLGLVLVGMGIGAGGTFVLTNPQWADHLTNNSVISPLVTNQSIAPANESLATNLQSRLSPREPSNFVVDVVESTGPAVVRINAQKTVKSQVPQAFNDPFLQRFFGSQMPPMPNERVQRGTGSGFIVSNDGKIFTNAHVVDGADEVTVTLKDGRSFPGRVMGSDPSTDVAVVKIEAGDLPTVALGDSDHLQVGEWAIAIGNPLGLDNTVTTGILSATGRRSADIGVPDKRVEFIQTDAAINPGNSGGPLLNADGQVIGMNTAIIQNAQGIGFAIPINKAQEIAQQLIATGKVEHAYLGIQMVTMTPELQSQIRQETGMNIPVDKGVVIMQVMPNSPAAIAKLEQGDVLQSLQGQPVENAEQVQSLVGKLAVGDEVELGILRNGQQQNLTVTIGALPSAPPQ
What is the function of this protein?
A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB.
What are the official names of this protein?
Putative serine protease HtrA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell outer membrane; Single-pass membrane protein.
Protein: Y2498_STAAW
Sequence: MRKDAKENRQRIEEIAHKLFDEEGVENISMNRIAKELGIGMGTLYRHFKDKSDLCYYVIQRDLDIFITHFKQIKDDYHSNYEVMQVSLDYLLQFKIDNKALLQCIEAGNNKLRFYQSAFYQELFDFYYDLFKSDDDTYTKFKTDMLLQSLSTSVFAFQIEHRHISIEAYRNYLLNIYLDEVERND
What are the official names of this protein?
HTH-type transcriptional regulator MW2498.
Protein: PURQ_METBF
Sequence: MKIAILQFGGTNCDQDVLHVLKDVVGVDAETVWYKQEDLTGFDGVVVPGGFSYGDYLRAGAIAARTPIMNSVKKLAAEGKPVLGICNGFQILTEARVLEGALTTNEYPKFRCHWTNLRVETVDTPFTSKFRKGEVIRMPIAHMEGQFYAEEKTLAELDENEQVVFRYVDENGKVTDEANPNGSLENIAGIVNTSRNIFGLMPHPERASESILGSDDGLRVFESMVDYITENF
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4C_SOLTU
Sequence: MNYFPWLTIIVVFPIFAGSLIFFLPHKGNRVIRWYTICICILELLLTTYAFCYHFQSDDPLIQLVEDYKWIDFFDFHWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDSRLFHFLMLAMYSGQIGSFSSRDLLLFFIMWELELIPVYLLLAMWGGKKRLYSATKFILYTAGGSVFLLMGVLGVALYGSNEPTLNFETSVNQSYPVVLEIIFYIGFFIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHSIFSPWLMIIGTIQIIYAASTSLGQRNLKKRIAYPSVSHMGFIIIGISSLTDTGLNGALLQIISHGFIGAALFFLAGTTYDRIRLVYLDEMGGIAIPMPKMFTMFSSFSMASLALPGMSGFVAELIVFFGIITGQKYLLIPKLLITFVMAIGIILTPIYSLSMPRQMFYGYKLFNAPKDSFFDSGPRELFLSISIFLPVIGIGIYPDFVLSLAVDKVEVILSNFFYR
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y2023_SODGM
Sequence: MNLQHHFLIAMPSLQDPLFKRSVVYICEHNSDGAMGIVINKPVEQFTVENVLHKLKIMPADRDPAIRLDKPVFAGGPLADDRGFILHTPRDGFGSSIGISPQTMITTSKDVLETLGTADQPDDVLVALGYSGWEQGKLERELMENAWLTTPADSEILFHTPIASRWREAAKTLGIDIHNIANQAGHA
What are the official names of this protein?
UPF0301 protein SG2023.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: LEPA_CELJU
Sequence: MTDLSHIRNFSIIAHIDHGKSTIADRFIQICGGLSDREMEAQVLDSMDLERERGITIKAHSVTLNYKARDGKTYQLNFIDTPGHVDFTYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVIPVLNKMDLPQAEPDRVAQEIEDIIGLDATEAVRCSAKSGLGMEDVLEELVRLVPPPTGDVGAPLQALIIDSWFDNYLGVVSLVRVVQGTLRLKDKIIAKTIGKSQLVDGLGVFTPKPLQLKELKAGEVGFVVAGIKDIHGAPVGDTITHAQTPDVEALAGFQKIKPQVYAGMFPVSSDDFESFREALAKLTLNDASLFYEPESSDALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVYEIETAKGETIFVDNPSKLPDPGSINEMREPIVEANILVPQEHLGNVITLCVEKRGVQKDLQFTGSQVAVRYELPMNEVVTDFFDRLKSVSRGFASLDYNFLRFQPAKLVRLDVLINGDKVDALALIVHRDKSQHMGRQLVEKMKDLIPRQMFDVAIQAAIGGQVVARSTVKALRKDVLAKCYGGDATRKKKLLEKQKAGKKRMKQVGNVEIPQAAFFAVLKIDS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MMS22_SCHPO
Sequence: MNSFLLLDHVSDSQDSGSEWSNTHGSLISQRGNEYDGITPATKEKNQNKLEILNNETTIGSTKSSVSSLPELNRNVSFEKSDQNLAETKREEENKRTEVFKKDAEHEAVVVKRDFRPRRPEQTRPYTYDFLRHQIEFKRIGLVPITVPHGFSSDRSITSKSSHKPVNVIVRNRASSRKPPLTSTHRFRRYGAVISDSDDDESNTEQDHSKESNLNTADNDLALSSTIEGKKTSTSKEALESESLLSDSDQSMTNISSNSTVSDLNLKTLKKRLRGVLPPSFLTLQEKKKLENRGVKKKTSLHKSVIEGEKIKGVARRKLHPRSTAKLSSELGNEISDSDNSISTPTPTDDSRFDTSEFLDSISRDNGWLKEDVVDQLWLPKRSLSALKKSSSLTSENPFQLNVAANAVSTIPVYRTTKTKMKKNRFKYVEVEKLPDLILESYGKKAPKFLRVFARSSSHIPKMIRRKRQMDSKKYFSFDKESDRQVIDQVLSDWYSGKHELVQQSHSYKKPSDSKSVGGNIFSVNSKKHSVNINAKTAANNGLSHLQNFSEELLKKRKLFSSLFSNNVSYKKSKKLKRTHTVHDKCQKVAKLDHYIRDNIELNSKEREHDCYEGTLAVPQVNTEIRKSSRKQKAQRFIRDDFDTVFFQSSSNPNYFTDVNPFWNIGIWSTTFNVITFRPGLSLPNNSFIKTQGLNSILQLDIVTHPFKSVYAFSCLFNIQDDVFKTFEKLKDTFETVLENLPYFTNSETVDLYNLLSFCSAFILHSQVSMGLVNLASSFLETYALVNDRVSSISGLNRSQLVEKIAVLFQTFQVVFYCEFELGNQQNINKVSWLASDLISKLLSAGQSGLLECYRNLRIQASDTTVIDTLFLESWSILNHILFHVYKKKYALWEQVNSFFDLQKKELSILEMEKIWYVIMTLNPVFQIGLNGTTHSPGNNSFWPLIIRVSESAFKMHKDGHNVKVVERYLRTVFLRIHFLISEWRWEDVAQILFLIFDFFSHRKFNDLSSEISEDTPTDFPDFVKSLDRPPNLHVTALDTCFVIYLKVILISISRLRQVDENTNSIKRIVSRLQPLHSRQYTRESPFSIKDFMSLEHTHTLLICLYWAAPENCRPSLNRIRDIVIVDNSHLKARLISLKAWLHLMKYVIKEGTDYELAQGMEWFNSILKVTFDEYLALFSNGTSVGEMQLAEYSKHQLENALIVAFHSLQDLIPNSSVYISRINVLVTEQSCRRILKDSHFFPPRVTLECILFLKKFLQYQSNTEPPKVTVVGSTSHDSQDAYFDSDVLDDNTLILEQEKFERKYEVAQILRTFVSPFLYQTISYLVGNDEDKENYIRILLLPLMECMAICASFAVEAKINDWSYYIDFGSESWERIRNTPLKRSLSTTFYSFLISYNDSFIKKHEEKVLTVWFESLGALDEDHAAQFTILLLQKNLKNPILLNLPISVKIEEISINYFKSVHLNLLTAVFCNMAKLYADAKTNGFASSQYLQSLFIHYLSSLLSSMQHSYETNGHSSDTHSLFVINSQRVVGDILQYCSQFANDRNLPALRYFMDSTKFPQPPERLEYTALRLRSYARKTLTNSASQNALFSFLKANFDVALLEQKQTETSNLLRLAMGFHNQNSSSKWDVEISSLRKFCVKELLLSYLGEGSLAAMFYSLLLLEGLSRTYNSFRRIYLQPYIQQLLCEEISVFVADLEKYALLYENKRPLLSGRIYYLISSFVAISMTNKTSGLPSSLICNLQNFLARIARDFLLELCWNIEGSEFPPPYNTVDCRSKFVKTIQQHCSADWYDNVTNIVHKSRKKKLVLPSQVEQEEEYWSGLMEVTIQIWKHDKGFLEPELDRFLNVICSYAPDMSGLPTKIKCFLDKIGYSWMTEENDFDIVLF
What is the function of this protein?
Involved in protection against replication-dependent DNA damage.  May act by restoring active replication forks, repairing unusual DNA structures, and/or preventing aberrant DNA rearrangement at arrested replication forks.
What are the official names of this protein?
Protein mms22, Protein mus7.
What is the protein family that this protein belongs to?
Belongs to the MMS22 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ES8L2_PONAB
Sequence: MSQSGTMSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELENFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPQAKNRVGPQVPLSEPGFRRRESQEEEPRALLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCGGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPWEPQVPLYVPKFHSGWEPPMDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTVQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS
What is the function of this protein?
Stimulates guanine exchange activity of SOS1.  May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity).  In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
What are the official names of this protein?
Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the EPS8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, stereocilium. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells.
Protein: SYD_KLEP3
Sequence: MRTEYCGQLRQSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRAREEKNINADMATGAIEVLASDLTIINRSESLPLDSNHVNTEEARLKYRYLDLRRPEMAQRLKIRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREIMEAMVRQLWLEIKGVDLGDFPIMTFAEAERRYGSDKPDLRNPIELVDVADLLKSVEFAVFAGPANDPKGRVAALRVPGGASLTRKLIDEYGNFVKIYGAKGLAYIKVTERAKGMDGINSPVAKFLTAEIVEAILERTGAQDGDMIFFGADNKKVVADALGALRLKLGKDLSLTDESKWAPLWVIDFPMFEDDGEGGLTAMHHPFTSPKDMTADELKAAPEEAVANAYDMVINGYEVGGGSVRIHRGDMQQTVFGILGINEHEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANPAALGELGIQVVEKEAKASLENK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_STAA8
Sequence: MFDQLDIVEERYEQLNELLSDPDVVNDSDKLRKYSKEQADLQKTVDVYRNYKAKKEELADIEEMLSETDDKEEVEMLKEESNGIKAELPNLEEELKILLIPKDPNDDKDVIVEIRAAAGGDEAAIFAGDLMRMYSKYAESQGFKTEIVEASESDHGGYKEISFSVSGNGAYSKLKFENGAHRVQRVPETESGGRIHTSTATVAVLPEVEDVEIEIRNEDLKIDTYRSSGAGGQHVNTTDSAVRITHLPTGVIATSSEKSQIQNREKAMKVLKARLYDMKVQEEQQKYASQRKSAVGTGDRSERIRTYNYPQSRVTDHRIGLTLQKLGQIMEGHLEEIIDALTLSEQTDKLKELNNGEL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECY_BORBU
Sequence: MKELFLSLFTVKDLRNKFLFTLFVLFLFRVGSYLPIPGIDSVALKSYFKSQSDFSIANYFDFFSGGAFSNFSIFMLSIGPYISASIIVQLLVYSFPSLKKMQEGDGGRQKTKKYTKYLTIVAAVVQGYATSLYAKGIPGAVTIPFYRYIFVAILTVTTGTFILLWFGEQINQRGVGNGTSLIIFSGIVVRLQAALFNLFQSMQDPSQNVNPVFVILIISIFILVVILIIYEYKAQMRIAIHYARANSNNTVSSYLPIKLNPSGVLPVIFASVLITLPLQILSGFAETSSIARQILSYLRPNGFYYTFLNVILIIGFTYFYSKIQLSPKDISNNIRKNGGTIPGIKSDEMEKYLDEIMNKTLFSGSIFLSIIAIIPFLVQNIFRFPHDVSRIMGGSSLLIMVGVALDTLIHIDAYLKTQGFSHGNKKNYAFLQKI
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRC_MYCBO
Sequence: MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGKVTARDGKIRA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: PNP_XANOP
Sequence: MAKITKTFQYGKHTVTLETGEIARQAGGAVIVKFDDTVLLVTAVAAKSAREGQDFFPLTVDYQEKFYAGGRIPGGFFKREGRATEKETLISRLIDRPIRPLFPEDYKNEVQIIATVMSMNPDIDGDIAALIGASAALSLAGTPFNGPIAAAKVGYKNGEYILNPTVTDLKDSQLELVVAGTANAVLMVESEAELLSEEVMLGAVTFGHREMQKVINIINELAVEAGTKPSDWVAPAKNDGMIAALKEAVGDQLASAFQVRDKLQRRDAISAIKKDVLGALAPRATIEGWAAGDLAKEFGELEYQTMRGSVLSTKVRIDGRALDTVRPISAKAGVLPRTHGSALFTRGETQAIVITTLGTARDGQVIDAVSGEYKENFLFHYNFPPYSVGECGRFGAPKRREIGHGRLAKRGVLAVMPSLEEFPYTIRVVSEITESNGSSSMASVCGSSLALMDAGVPIKAPVAGIAMGLVKEGNDFVVLSDILGDEDHLGDMDFKVAGTAEGVSALQMDIKIEGITEEIMKQALQQAKAGRLHILGEMAHALTTPRQELSDYAPRLLTIKIHPDKIREVIGKGGSTIQAITKETGTQIDIQDDGTIIIASVNAIAAQAAKSRIEQITSDVEPGRIYEGKVAKIMDFGAFVTILPGKDGLVHVSQISSERVEKVGDKLKEGDLVRVKVLEVDKQGRIRLSIKAVEEGEGVPASAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIS1_ASPOR
Sequence: MPPLLTNRQAEELHKSMIAYLVASDLPDTAAALRREVNLSEDVFDPTTAKRYEGMLEKKWTSIARLQKKIMDLESRNATLQSELDNSTPASRLKRNQDPASWLPSTVRYSLESHRDKVNCVAFHPTFSSIASGSDDCTIKIWDWELGELERTLKGHTRAVRDVDYGGPRDNVLLASCSSDLSIKLWKPTDNYKNIRTLQGHDHIVSAVRFIPSRNLLVSASRDNDMRIWDVTTGYCVKTINGHTDWVRDVSISFDGRFLFSTGQDMTARLWDISTVSNIEHKRTMLGHENFIECCAFAPPTSYQFLAPLAGLGKRPSSTNGADFMATGSRDNTIKIWDSRGTCLMTLVGHDSWVQALVFHPGGKYLLSVSDDKTLRCWDLNQQGKCVKTLDAHESFVTSLRWAPGVAKNVPGGDGAAEGEGNDKNGAGSENPANIQMRCVVATGGWDQKLKIFAG
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein nudF, Lissencephaly-1 homolog, LIS-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: IMM1_ECOLX
Sequence: MSLRYYIKNILFGLYCTLIYIYLITKNSEGYYFLVSDKMLYAIVISTILCPYSKYAIEYIAFNFIKKDFFERRKNLNNAPVAKLNLFMLYNLLCLVLAIPFGLLGLFISIKNN
What is the function of this protein?
This protein is able to protect a cell, which harbors the plasmid ColE1 encoding colicin E1, against colicin E1.
What are the official names of this protein?
Colicin-E1 immunity protein, ImmE1, Microcin-E1 immunity protein.
Protein: KLH25_RAT
Sequence: MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKVHLPLLLRNVRLALLPSDCLKKAVSGEALLMADECTKLIIDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSDNRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITSVPYSLIPTAFVSTWKHLPA
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis.  The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low.  The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.  The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis.  BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells.
What are the official names of this protein?
Kelch-like protein 25.
Protein: PSD8B_ARATH
Sequence: MDPQLMEVSQQFERFKAAFIIKDFDTCSSLLSQLKLFDHYLISLSLNALLLLTCALFFLCTRNRIPPSPQENLIMGLNLLRLLVQNRIAEFHTELGLLSSATLENPCIKHAVELEQSFMEGAYNRVLSARQTAPDETYVYFMDLLAKTIRDEIAGCSEKAYDHLSISEGCKMLLFSSDQQLLTYVNEEHPEWEVKDGLVVFQKTRETAPCKEIPSLQLINQTLSYTRELERIL
What is the function of this protein?
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
What are the official names of this protein?
Putative 26S proteasome non-ATPase regulatory subunit 8 homolog B, 26S proteasome regulatory subunit RPN12b, AtRPN12b, 26S proteasome regulatory subunit S14 homolog B.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S14 family.