PharMolix/UniProtQA huggingface dataset:
Protein: MBLC2_BOVIN
Sequence: MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSSGLLRDRAARDNAACRPLLAVATHVHFDHSGGLYQFDRVAVHHAEAEALARGDNFETVTWLSDSEVVRAPSPGWRARQFRVQAVQPTLVLQDGDVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNSRTSP
What is the function of this protein?
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.  Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA).  Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18.
What are the official names of this protein?
Acyl-coenzyme A thioesterase MBLAC2, Acyl-CoA thioesterase MBLAC2, Beta-lactamase MBLAC2, Metallo-beta-lactamase domain-containing protein 2, Palmitoyl-coenzyme A thioesterase MBLAC2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor.
Protein: ISPH_LISMC
Sequence: MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVDGANREEILDKITTGTVIFTAHGVSPSVKAKAAAKGLTTIDATCPDVLHTYNLILEKQAAGYEIIYIGKKGHPEPEGAYGTAPDVVHLVETKADIDALSLLSDNIFVTNQTTMSKWDVADLMDYIKEKFPKAIQHQEICMATQVRQEAVAVQAKGADLTIVVGDPRSNNTARLAQVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKTTWKRAHNKDFERILPKMKNKYMAEKRRQRLAHLKNGGS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: HEM1_SYNC1
Sequence: MNFLVIGLSHKTAPVELRERISFSSDDPGGVLRAITALPGISEGMILSTCNRVEVYAASGDPAGGCACLQRFMAEHHGLDEAQLKPHLYIHSGRDAIRHLFRVASSLDSMILGEPQILGQLKEAYNLAESSCTAGPVLNRLLPRAFAAAKRVRNETAIAQHAVSVSYAAVELARKIFGDLAGKSVMIVGAGKMCELAARHLTGQNIGEVLVTNRTLARAQSLAEQFGGRAIPFAEFPLYLNQADIVLTSTAAGGLLLTRAQLEQIIRQRKNRPMFLIDIAVPRNIDPEVNHIDNVYLYDIDDLNGVIETNLRERRKAAKKAEDIIEQEIVRFYSWLRSLEATPMIVALRRQVEDIRRTETEKTLGSLQHLDAGDRRAVEALTRAIVNKVLHSPLSVLKRAGDDITGEIYLEAVRRLFDLNPDSQQTGGDSVEKDADSKQDLTS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MUTL_RICAH
Sequence: MTIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKLDESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRSDKTELVATVDVVKKIALAHPKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYTSIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNLLIEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVSKAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKIEQEVERRIEREQQAHKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELPNERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGENIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKLKDIERLFGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: UBIA_PARXL
Sequence: MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGRPSLPLLVIFTVGTVLMRSAGCAINDYADRDFDRYVRRTENRPITSGKIRAWEAVALAAALSLLAFLLILPLNALTKELSVAALFVAGSYPFTKRFFAIPQAYLGIAFGFGIPMAFAAIQNHVPMLAWVMLLANVFWSVAYDTEYAMVDRDDDIKIGIRTSALTFGRFDVAAIMLCYAVTLGIYVGIGVLLGFGALYWLGWAAAAGCAIYHYTLIRNRERMACFAAFRHNNWLGGALFAGIAAHYAATWF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFP_SYNPW
Sequence: MISSNDFRTGTTIELDGAVWRVVEFLHVKPGKGSAFVRTKLKAVQSGNVVEKTFRAGEMLPQAILEKATLQHTYMEGEDYVFMDMGTYEETRLSAKQIGESRKYLKEGMEVNVVSWNDKPLEVELPNSVVLEIKETDPGVKGDTATGGTKPAILETGAQVMVPLFLSIGEKIKVDTRNDTYLGRENS
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCP3_MOUSE
Sequence: MVGLQPSEVPPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQGENPGAQSVQYRGVLGTILTMVRTEGPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQFYTPKGADHSSVAIRILAGCTTGAMAVTCAQPTDVVKVRFQAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDIIKEKLLESHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPLGRYRSPLHCMLKMVAQEGPTAFYKGFVPSFLRLGAWNVMMFVTYEQLKRALMKVQVLRESPF
What is the function of this protein?
Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:10748195, PubMed:10748196).  Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:29212043).  However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458, PubMed:20363757).
What are the official names of this protein?
Putative mitochondrial transporter UCP3, Solute carrier family 25 member 9, Uncoupling protein 3, UCP 3.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LIPA_TOXGO
Sequence: MAYFFDFPTDTWVEDASPGGPPKRAFGHGLAAGSSHFASPVSRRRLPTITALLLFSLLSASQSGALSVSQCSRRVSLGPLLSRVSSVSCTPSAAASALASSLYPTDSLSSVEGSVAPRPPPSSLAFVLRRVPPAAYSSSLSPSVLRFKHSLPRPLQGSLVCAPGILGGAAGSARFAGCCGSQGRSCGSGKNPELPLKGSKDEVIPRVGTSTAGPRPDWFHVPAPQAASRGAEESRYQQLQKQIRGLDLHTVCEEAKCPNIGECWNGGTATLILLGDTCTRGCRFCAIKTSSKPPPPDPLEPEKVADAVAKWDIDYVVMTSVDRDDMPDGGAGHFARTVQLVKKAKPSMLIECLVSDFQGMEESVRTLAQSGLDVYAHNIETVRRLTPYVRDKRAKYDQSLRVLHLAKQFNPSLFTKSSIMLGLGETSEEVVRTLRDLRDHDVDVVTLGQYLRPTKQQLGVVEYVTPETFKKYQDIAEEMGFKYVASGPLVRSSYKAGEYYMKHLIDDARKHGRRETVKQVKLEADVGTLKGTTTTFQVNEKEA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, apicoplast, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Plastid, apicoplast.
Protein: MAO1_ECOK1
Sequence: MEPKTKKQRSLYIPYAGPVLLEFPLLNKGSAFSMEERRNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNIQDTNETLFYRLVNNHLDEMMPVIYTPTVGAACERFSEIYRRSRGVFISYQNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRNPRITDDEYYEFVDEFIQAVKQRWPDVLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRAAGGQLSEKKIVFLGAGSAGCGIAEMIIAQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDWDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGLVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWHAEYRDYRRTSI
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: 36014_ASFP4
Sequence: MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQIFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCTELGGLTPVTEPRLLEILKEVAKLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLQKKNYAAIYYCYRLGASLDYGMNLSIYNNNTLNMFFCIDLGATDFDRAQHIAHKAYMYNLSNIFLVKQLFSRDVTLALDVTEPQEIYDRLKSYTSKNLKRAEEYLTAHPEIIVID
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.  Inhibits also the host cGAS/STING-mediated type I interferon production by inducing host IRF3 degradation through the proteasome pathway.
What are the official names of this protein?
Protein MGF 360-14L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SCAR4_ARATH
Sequence: MALTRYQIRNEYGLADKELYQSADKEDPEALLEAASMAGLVGVLRQLGDLSEFAAEVFHCLHEQLMTTAARGHGLAMRLQHLEADFPSVEIPILSQTDHSTFFYEPGLEWHSDLQTKEDLISPRNLPRCIMDSYEECHGPPQLFLLDKFDVAGSGSCLKRYSDPSLLKTHTTSAVVATSKLGKDKRLRQSKKKGSHTTIKETPEDSRTSHAKLHQLFFLEHVENGHRNPEFHVKLKRRQLNGPPINSSSGASYMEKFLKNSSPYCERVHGTMDQSSPAMETEVTVCSEQEDLPIPSLVYSNSGGTRKYNEMEIESIAGHEILEIPFVPHEITVNEKSPVVCLESSSSVNLCCKTNNDADSPASTESEVKEAGSDDKAGCDHGFPGFGQPQICTNAEVNQTEVLTQFSNVLRHSPEEGESSLLCTDIQRASPESKPHKAEEAAVDLDESFSQMTPDIDSAGMGTLEILQTPFSLSCYESPANLPEDSGSHLELQSNKANAEACEVFEVRRDPMLNISPETHLLKVTQVPQDAYEGGTNDVHSQHVFSVETASEISVSALVEDQFSSITNQEIEALESEDISSEAGHFIPDTKKSLNETSVALESDFLLPNHYISTFDNFEDLSLSADAQDYAAPKEDETNSQDGSSMNPAQSKHISTSEISSENGTLMSDTPRDLHTGYGSLSASSCLEDGLANPDLAEISSYSGQEDPQTMSIVSDDSSDPEVPIPDGTCFAGDVDHDNQTGLNNKAIETVPQKELETISDPQESLLGTEECLSSEYCLQIQNQRQESPSETGSANSRTSSDESPPTQNGSVGVQSSPLDVFPSSITEIEALHAPYQEIFTSLNDHISESVLSKGLTDEEDFLNVSPESILPLSTSLHETPQANPEITPPLPPLPPTQWWMGKLVESTEMPSLAGSGNNSFNIQRDENTQNGSVQANEAQYPSEVSVTDGENHNFHIYTEESKATEEQSPSGVNGTSDTYMESKHKCLNRTPEDSFSLAESAQGLEADWRTEAMALEWFSQNLREHNNPHPAKLEEEEPQVDHPLEKPGQTKFRQTLRDNNSYNQNQKAGKLKRDEDTLVIGIDRSMLRKVSEGNRTHVGARVDENDSLLEIIRSKSFNLRPADASGRPNFQVAVPKTNLKVAAILEKANTLRQAMAGSDDEHDSDSWSE
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex.  Regulates trichome branch positioning and expansion.
What are the official names of this protein?
Protein SCAR4, AtSCAR4, Protein WAVE3.
What is the protein family that this protein belongs to?
Belongs to the SCAR/WAVE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TRMD_SHEDO
Sequence: MWLGVITLFPEMFRAVTDFGVTGRAVKNGLLELHTWNPRDFTHDRHSTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGDGAKVIYLSPQGRKLDQHGVTELAKSDSLILVCGRYEGVDERIIQTEVDEEWSIGDYVLSGGELPAMTLIDSVARLVPGVLGKQASAEQDSFSEGLLDCPHYTRPEQLDGMDVPAVLLSGDHEKIRLWRLQQSIGRTFLRRPELFENLALTDEQTTLLAQFVNDTDKSA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_CLOPS
Sequence: MKMKAYAKINIALDAIGKREDNYHLLRMIMQTVDLYDVIDIEKSNDSNISISCNKHYVPTDERNLGYKAAVLFRDEFNIKNGVKISIKKNIPVAAGMAGGSTNAAAVLVIMNKLFNVNASLEVLKEIGLKIGADVPYCIEGGTALCEGIGEIITPLKPFENKILVVLKPNFGVSTKEVYTNLDINKIRKHVNIEGLIQAMENDDLDYVSKNMKNVLENVTLKKHTILKNIKEDMRKSGALGAMMSGSGPTVFAFFDDMLTAQRAFEFLKGKYKYSDVYITRTINSNNL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: DPOL_GPCMV
Sequence: MSAPVFFNPYLCGGAARRRNGCSTVDSRRGNGPTKKGKKSFLQVVPRGVIYDGEKGLIKKVTQHPPRMFYNNVQYLLEPQMSWPTLPCRETCRVGCGREQPLRFHTFDQIDSTVYADSVEQIFLGYRRHVVPCGNVIRMFGRTCDGSSVCVNVFGQPSYFYCEYDGSEGYLDNYLSTVLKETEDVTKIVFTLDAQRVHKYSLFGYNTKYIENLYRVTLNNWPVCKRLAQNLQSRGLRVYEAGVDPVARFCVDRKIPSFGWCVIKRFYARSSGLASFCDIEIDCEIGDVEADDSDMSWPEYRCASFDIECMSGGDRFPDSSMVDDIVIQISVICYAVGRSGAESDGVSGAEAAVREHQHLFTLGPCAPIPGTHVYEFPSEYELLLGFFIFFKAYSPDILTGYNINLFDIKYLLQRMEKIYHANVSEFTKLRFGGRFSIYVPVGNKPRNASSASIKVHCTGTVVLDMYPVCVAKTSAPNYKLETMAEMYLNEHKDDLSYKEIPPTFLANDNGRAVVGRYCIKDALLVKRLFEKLNYHYEAASVARLARIPLRSVIFEGQQIRIYSCILEEAGERNMILPSFLTAKRPGELATESSPVASFEEDSEQTSDSSLGEVSSQGSSDGGVGYQGATVLEPDVGFYDTPVAVFDFASLYPSIIMRHNLCYSTYLPLGRDDGLSDDDVFLLEFDDGTRYGFVREHVRKSILGELLARWLAKRKSVRKVLAECQDEVEKLILDKYQLALKVTCNAFYGFTGVSSGMMPCLPIAAAITRIGRDMLMSVVDYVNTYMGHAEFWLRYLGEEDLTGDALNVKVIYGDTDSVFVICGGVKCGSVLEHGEAIAGHITRALFREPIKLEFEKVFVNLMMICKKRYVGRIYGQTKLSMKGIELVRKTACEYVKSTVRNVLNMIFFEDDVSAGAVELSRMTMDDVKRHGVPSGFYRIVEALSNARDELYLNRVDVKKLVLSASLSQEVSAYKQQNLPHLRVIQRLAARREELPSVGDRVPYVLIAPPPGSSKNVPNYEISEDPGYVIEHKLPVNGEKYFEHVVKTVTNVLGPIIPKDCARKEKFLSYVLPQRVYVSRPFMPYACAANELVVACDDGGVMMGVYGIKPVMCGVSVTN
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RL4_BIFA0
Sequence: MANVTLNVTDNNGKEAGTLEAPEALFGFTAEEVQAHVPLIHQVVVAQRAAARQGTHAVKNRGAVSGGGRKPWKQKGTGRARQGSIRAPQWYHGGVAHGPVPRDYSQRTPKKMKAAALRYALSDRANNGRVAVVDFQLDAPSTKKAIAALAPVVADNFTTVVLSRDNVNEWLSVRNIPTVYPIFADQLNTYDVITAQYVVFSKDGLEAFVAAKTAAKEA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: INSI1_XENLA
Sequence: MQTLEEHCWSCSCTRGRDKKGTKVSAWLARRVGKAMSSLNSLLSLAYSTLASSEGRSLIQRSLVLFTVGVFLALVLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSRIGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGSSEKTHGD
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr.  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs).  Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum.  In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi.  Sterol deprivation reduces oxysterol-binding, disrupting the interaction between insig1 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs.  Also regulates cholesterol synthesis by regulating degradation of hmgcr.
What are the official names of this protein?
Insulin-induced gene 1 protein, INSIG-1.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NCBP3_DANRE
Sequence: MAAVRSLRVSVKSDSASDRSESDSESDSDRDAREAEPMEVEEGEVELESIPVRRSLKELLPDTSRRYENKAGTFITGIDVTSKEAIEKKEKRARRFHFRAEENLTQKDVVLERDLLKKMIPKVRLEALHMSGVDDMSTQDVFGYFKEYPPAHIEWIDDASCNVVWLDDITSTRALINLSRMPDKEEVTNTDSSKPSELPVQTQKARRSRGSDDDDDDDEEEEGEVDDDDDDDEEDEKARDIEDETEKKPQETRETSLSQAERDSLLQNEPRPTVKPFKGNKLFLRFATHDDKKELGAARRSRYYMKYGNPNYGGMKGILSNSWKRRYHTRRIQRDILKTKKPLIGDSMGHTPPYTHRHSADLVNLPEEPIEEEEEEEEDGEEDMDADDRVVEYKDRGEKERGPRLVEGGLRSRLGGPSPTSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVETNLRSLRNSIRTESSGSVKSRIGGGGGGGSGGAVEGRGEGGSSKSTSEKVTDVRQLLEEKRQGLSQQRSRPPVATSGKTDVRQRLGKRPHSPERRRSVSPVISRKTASRREPLSDVRSRLGVAKHDNRSLFSEPPKDKKTGGLWSRLGPSHKDSGSGDEDKPSSRASSSRGIRRRKDEDSDGVEDEDEEDDSHLQKMWGAMIKQKEQQSNKMKKSRLDNLPSLQIEISRDGSNGSDSDS
What is the function of this protein?
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export.  NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80.  Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
What are the official names of this protein?
Nuclear cap-binding protein subunit 3.
What is the protein family that this protein belongs to?
Belongs to the NCBP3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: IL10_MARMO
Sequence: MPNPVLLYCLVLLAGMGTSQGENTQSEETCTHFPGGLPHMLRELRAAFGRVKIFFQTKDQLDDMLLSESLLEDFKGYLGCQALSEMIQFYLVEVMPQAENHSPDVKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVQQVKDAFSKLQEKGIYKAMSEFDIFINYIEAYMTAKINS
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUS7_BRAOL
Sequence: MAMITRNTATRLPLVLQSHRAAAVSHLHTSLPALSPATTPTSYTRPGPPSTSAPPPGLSKTAEFVISKVDDLMNWARRGSIWPMTFGLACCAVEMMHTGAARYDLDRFGIIFRPSPRQSDCMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGLLQLQKKINRRKDFLHWWNK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRPB_KLEP3
Sequence: MSTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPAFQAEFTDLLKNYAGRPTALTKCRNLTEGTRTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYEKAHYMLGTAAGPHPFPTIVREFQRMIGEETKAQILEKEGRLPDAVIACVGGGSNAIGMFADFIDETNVGLIGVEPAGHGIESGEHGAPLKHGRVGIYFGMKSPMMQTADGQIEESYSISAGLDFPSVGPQHAFLNSTGRADYVSITDDEALDAFKALSRHEGIIPALESSHALAHALKMMRENPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CUTI3_ASPFU
Sequence: MSLRSLFVAGLATLALAVPAPQIQARQGMSSNELESGPCRDVTFIFARGSTEQGNMGLIVGPGVCSSLKKDLGSDKVACQGVGGAYTAQLAPNFLSQNTNQASINAATDMFDLANTKCPNTKIVAGGYSQGSAVIDNTIQALGSDLKAKVKGVVLFGFTRNVADKGQIPGYPKDQTKIYCAVGDMVCVNTLIITPAHLTYGADAGDAAKFLASKVQE
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity).
What are the official names of this protein?
Probable cutinase 3, Cutin hydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUAC_CAEEL
Sequence: MSLKAWLGIDKIQKFGQMVKEIGGVKAVLKKRYLMDATRVGTLVGSDNFGNRYYENNAYFVPRNRWVEFPDKVWLDYDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKENTSIYADKKYVPYSTTRTKIQGWQPGEKPQFD
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12, NADH-ubiquinone oxidoreductase 17.0 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA12 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.