PharMolix/UniProtQA huggingface dataset:
Protein: SST_XYLF2
Sequence: MTEFIPPGSLFHALSSPFAMKRGGQLHHARIAYETWGRLNAGATNAILIMPGLSPNAHAAHHDSNAEPGWWESMLGPGKPIDTDRWFVICVNSLGSCKGSTGPASYNPITQAMYRLDFPALSIEDGANAAIEVVHALGIKQLASLIGNSMGGMTALAILLLHPDIARSHINISGSAQALPFSIAIRSLQREAIRLDPHWKQGHYDDTHYPESGLRIARKLGVITYRSALEWDGRFGRVRLDSDQTNDTPFGLEFQIENYLESHAHRFVHTFDPNCYLYLSRSMDWFDVAEYANGDIIAGLARIRIQRALAIGSHTDILFPIQQQQQIAEGLRRGGTHATFLGLDSPQGHDAFLVDIAGFGPPVKEFLDEL
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.
What are the official names of this protein?
Serine O-succinyltransferase, SST.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFL9_HUMAN
Sequence: MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE
What is the function of this protein?
Cytokine that binds to TNFRSF9.  Induces the proliferation of activated peripheral blood T-cells.  May have a role in activation-induced cell death (AICD).  May play a role in cognate interactions between T-cells and B-cells/macrophages.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: GGT1_PIG
Sequence: MKKRYLLLALAAVALVLLILGLCLWLPSNSKPHNHVYPRAAVAADALRCSEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEIINAREVAPRLASASMFNSSEQSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIELASQGFPVGKGLAAALERSQDAIKRHPALCEVFCRNGNVLREGDLVTMPRLAKTYETLAVEGAQAFYNGSLTAQIVKDIQEAGGIVTAEDLNNYRAELIEQPLRISLGDAQLYAPNAPLSGPVLALILNILKGYNFSRASVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVNVTEVVRNMSSEFFADQLRARISDTTTHPDSYYEPEFYTPDDAGTAHLSVVSDDGSAVSATSTINLYFGSKVRSRISGILFNDEMDDFSSPNITNQFGVRPSPANFITPGKQPLSSMCPVIIVGEDGQVRMVVGASGGTQITTSTALAIIHSLWFGYDVKRAVEEPRLHNQLLPNTTTLEKGIDQAVAAALKTRHHYIQDASTFIGVVQAIVRTPSGWAAASDSRKGGEPAGY
What is the function of this protein?
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4).  The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases.  In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound.  Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4.
What are the official names of this protein?
Glutathione hydrolase 1 proenzyme, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT 1, Leukotriene-C4 hydrolase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: EFTU_ALIB4
Sequence: MAKEKFSRNKPHVNIGTIGHVDHGKTTLTAAISAVLAVKYGGEMKDYDQIDNAPEERERGITIATSHIEYETAKRHYAHVDCPGHADYVKNMITGAAQMDGAILVIASTDGPMAQTREHILLSKQVGVPYIVVFMNKEDQLDPQDKEEMLELVEMEIRELLSTYDFPGDDTPIIAGSAFQALEEAKAGAVGPWGEKIVALMDAVDEYIPTPERDIDQAFLMPVEDVFSISGRGTVVTGRIEKGTIKVGEEIEIVGFGDTRKTTVTGVEMFRKEMDQGQAGDNCGILLRGIKKEDVERGQVLVKPGTITPHTKFRCEVYILSKEEGGRHTPFFSGYRPQFYVRTTDVTGSCTLPEGTEMVMPGDNVEMTVELVAPIALDKGTKFAIREGGRTVGAGVVAEIIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNAT_BOVIN
Sequence: MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRHVLGERRQRAPN
What is the function of this protein?
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.  May function as a regulatory subunit of ion channels (By similarity).
What are the official names of this protein?
Neuronatin.
What is the protein family that this protein belongs to?
Belongs to the neuronatin family.
Protein: DNAA_RICRS
Sequence: MSTNQIILTDQGDNYVNVWSHVAQDLYNHYGETLYNSWFSKVNFIESSLNTVILCAPTNFVRDWIKSKYSMVILQLFQHYNNTIKSIEIITKELPGTTQTVTELPTKTFADIGSSELNSENIFSTLDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSESNPLFLYGGVGLGKTHLMHAIGWYIKQHNPSRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLIDNNRQMVISCDRSPSDLDNIEDRIKSRLGWGLVADVHSTTYELRLGILESKIEQMNVKIPKDVIDFLASKIVSNVRELEGALNKVIAHSNFTLKEITLENTQNILRDLLRSNERIITVEDIQKKVASRYNIKLSDMSSSRRLREVARPRQIAMYLSKALTPKSLADIGKKFGKKDHTTVMHAIKKVEELLENDIELREEINLLMKILQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_GLUOX
Sequence: MGKSNVIQIRLVSSAETGYFYVTKKNARSATGKMEVRKYDPVARKHVVFREAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: HBB_BOVIN
Sequence: MLTAEEKAAVTAFWGKVKVDEVGGEALGRLLVVYPWTQRFFESFGDLSTADAVMNNPKVKAHGKKVLDSFSNGMKHLDDLKGTFAALSELHCDKLHVDPENFKLLGNVLVVVLARNFGKEFTPVLQADFQKVVAGVANALAHRYH
What is the function of this protein?
Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and may thereby play a role as a regulator of pain and inflammation.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CLPS_SHEB2
Sequence: MAKIGNIEHVEERVESELMPPSMYKVVLNNDDYTPMDFVIEVLQVFFRKNEQEATDIMLTIHHQGKGICGIFPFGIAETKVIQVNQFARQNQHPLLCSLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: THIC_PARPJ
Sequence: MNANPKFLSADAHVDEAAVAPLPNSRKVYVTGSRADIRVPMREISQADTPDSFGGEKNPPVYVYDTSGPYSDPEAKIDIRAGLPALRQAWIEERGDTEALTGLSSDFSRERAADTATADLRFKGLHRTPRRAIAGKNVSQMHYARKGIITPEMEYIAIRENQRRAEYLESLKTSGPNGEKLAAMMGRQHPGQAFGASAFGPNGLTAITPEFVREEVARGRAIIPNNINHPESEPMIIGRNFLVKVNANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTAKRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEDICEIMKAYDVAFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQTMIEGPGHVPMQLIKENMDLQLEWCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKTGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWEDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVTDDEALKKGMEVKSIEFMKKGAEIYQRQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: Y1102_STAES
Sequence: MYKRNERLNLIRKRVDQYGQVAVKDLAIFLQVTPETVRKDLETLENDKLITRTHGGAIQYNHINKEKSYANKWQKQSQVKERIAKKAALQIKSGEIIVIDGGTTTGRIPQYLNDITQTTIVTNSLKIADELNRAIEEQRIQAEVIMLAGKTNTEQDVVRGHMTNELLQRFKFDKAFISCGSFDTSDCYEFDLEEAHASHIMIQKSQLSYLLADSSKRDAHASYRIDGFSEIDYMISDYAKPQNIEYFNQKHWLQI
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator SE_1102.
Protein: YNN4_YEAST
Sequence: MSASIPETMKAVVIENGKAVVKQDIPIPELEEGFVLIKTVAVAGNPTDWKHIDFKIGPQGALLGCDAAGQIVKLGPNVDAARFAIGDYIYGVIHGASVRFPSNGAFAEYSAISSETAYKPAREFRLCGKDKLPEGPVKSLEGAVSLPVSLTTAGMILTHSFGLDMTWKPSKAQRDQPILFWGGATAVGQMLIQLAKKLNGFSKIIVVASRKHEKLLKEYGADELFDYHDADVIEQIKKKYNNIPYLVDCVSNTETIQQVYKCAADDLDATVVQLTVLTEKDIKEEDRRQNVSIEGTLLYLIGGNDVPFGTFTLPADPEYKEAAIKFIKFINPKINDGEIHHIPVKVYKNGLDDIPQLLDDIKHGRNSGEKLVAVLK
What are the official names of this protein?
Uncharacterized protein YNL134C.
What is the protein family that this protein belongs to?
Belongs to the YCR102c/YLR460c/YNL134c family.
Protein: GLUQ_CROS8
Sequence: MSVKPYIGRFAPSPSGELHFGSLIAALGSYLQARALKGQWLVRIEDIDPPREVPGAADAILRQLDHYGLHWDGEVLYQSQRHEAYREALAYLREHGLSYYCTCPRSRIQQLGGIYDGHCRALRHGPENAAVRLVQTHPVMAFTDKLRGDITADPALAREDFIIHRRDGLFAYNLAVVVDDHFQGVTEIVRGADLIEPTVRQISLYQQFGWQAPDYVHLPLVVNPDGNKLSKQNHAPPLPEGDPRPVLVEALAFLNQPVDDDWRALSTETLLRQAVEKWDLSAVPAAAAANPAFSNALR
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: CTNS_HUMAN
Sequence: MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGYDQLN
What is the function of this protein?
Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:15128704).  Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030).  In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (By similarity).  Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity).
What are the official names of this protein?
Cystinosin.
What is the protein family that this protein belongs to?
Belongs to the cystinosin family.
What are the subcellular locations of this protein?
[Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein. Note=AP-3 complex is required for localization to the lysosome. SUBCELLULAR LOCATION: [Isoform 2]: Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: PTR45_ARATH
Sequence: MEHNKVDTEPQDSYDDQQKWVLDSSTDSRGEIPLRAQTGAWRAALFIIGIEFSERLSYFGISTNLVVYLTTILHQDLKMAVKNTNYWSGVTTLMPLLGGFVADAYLGRYGTVLLATTIYLMGLILLTLSWFIPGLKACHEDMCVEPRKAHEIAFFIAIYLISIGTGGHKPSLESFGADQFEDGHPEERKMKMSYFNWWNAGLCAGILTAVTVIVYIEDRIGWGVASIILTIVMATSFFIFRIGKPFYRYRAPSGSPLTPMLQVFVAAIAKRNLPCPSDSSLLHELTNEEYTKGRLLSSSKNLKFLDKAAVIEDRNENTKAEKQSPWRLATVTKVEEVKLLINMIPIWFFTLAFGVCATQSSTLFIKQAIIMDRHITGTSFIVPPASLFSLIALSIIITVTIYEKLLVPLLRRATGNERGISILQRIGVGMVFSLFAMIIAALIEKKRLDYAKEHHMNKTMTLSAIWLAPQFLVLGVADAFTLVGLQEYFYDQVPDSMRSLGIAFYLSVLGAASFVNNLLITVSDHLAEEISGKGWFGKDLNSSRLDRFYWMLAALTAANICCFVIVAMRYTYKTVQPSLAVVADGGDDVETATGTNNTSKFT
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 5.7, AtNPF5.7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HOA2_COMTE
Sequence: MSLKGKKITVHDMTLRDGMHPKRHQMTLEQMKSVATGLDAAGVPLIEVTHGDGLGGSSVNYGFPAHTDEEYLSTVIPLMKQAKVSALLLPGIGTVDHLKMAHELGVSTIRVATHCTEADVSEQHIAMARKMGMDTVGFLMMAHMYSAEGLVKQAKLMEGYGANCIYITDSAGYMLPDDVKERLSAVRQALKPETELGFHGHHNLAMGIANSLAAVEVGANRIDAAAAGLGAGAGNTPMEVLVAVCARMGIETGVDVFKIQDVAEDLVVPLMDFPIRIDRDALTLGYAGVYGSFLLFAKRAEAKYGIPARELLLELGRRGMVGGQEDMIEDTALTMVRERQKLGHKVAVAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: MOV10_HUMAN
Sequence: MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL
What is the function of this protein?
(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV).  Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
What are the official names of this protein?
Helicase MOV-10, Armitage homolog, Moloney leukemia virus 10 protein.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Nucleus. Cytoplasm. Note=Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).
Protein: HEM3_BOVIN
Sequence: MSGNGNAAAIAEEDTPKMRVIRVGTRKSQLARIQTDSVVATLKALYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALERNEVDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILATAGLQRMGWQNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERSFLRHLEGGCSVPVAVHTAIKDGQLYLTGGVWSLNGAETMQDTMQTTIHVPVQHEDGPEDDPQLVGITARNIPRQPQLAAENLGISLATLLLNKGAKNILDVARQLNEAH
What is the function of this protein?
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen.  Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen.  The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled.  In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.
What are the official names of this protein?
Porphobilinogen deaminase, Hydroxymethylbilane synthase, HMBS.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ACSL3_PONAB
Sequence: MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCNSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQIVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
What is the function of this protein?
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity).  ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity).  Has mainly an anabolic role in energy metabolism.  Mediates hepatic lipogenesis.  Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates.  Both isoforms exhibit the same level of activity (By similarity).
What are the official names of this protein?
Fatty acid CoA ligase Acsl3, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 3, LACS 3, Long-chain-fatty-acid--CoA ligase 3, Medium-chain acyl-CoA ligase Acsl3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: F107A_HUMAN
Sequence: MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL
What is the function of this protein?
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics.  Mediates polymerization of globular actin to F-actin.  Also binds to, stabilizes and bundles F-actin.  Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity).  Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869).  Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741).  May play a role in tumor development (PubMed:10564580).
What are the official names of this protein?
Actin-associated protein FAM107A, Down-regulated in renal cell carcinoma 1, Protein TU3A.
What is the protein family that this protein belongs to?
Belongs to the FAM107 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Synapse. Note=Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869).
Protein: SLYX_RHOP2
Sequence: MADDQSLSARIEALEMRLTYQDETIETLNQAVTAQWQQIDALTRQIAALSDRLAQAETSVAAPANERPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: ALFC5_ARATH
Sequence: MSAFVGKYADELIKTAKYIATPGKGILAADESTGTIGKRFASINVENIESNRQALRELLFTSPGTFPCLSGVILFEETLYQKTTDGKPFVELLMENGVIPGIKVDKGVVDLAGTNGETTTQGLDSLGARCQEYYKAGARFAKWRAVLKIGATEPSELSIQENAKGLARYAIICQENGLVPIVEPEVLTDGSHDIKKCAAVTETVLAAVYKALNDHHVLLEGTLLKPNMVTPGSDSPKVAPEVIAEYTVTALRRTVPPAVPGIVFLSGGQSEEEATLNLNAMNKLDVLKPWTLTFSFGRALQQSTLKAWAGKTENVAKAQATFLTRCKGNSDATLGKYTGGASGDSAASESLYEEGYKY
What is the function of this protein?
Fructose-bisphosphate aldolase that plays a key role in glycolysis and gluconeogenesis.
What are the official names of this protein?
Fructose-bisphosphate aldolase 5, cytosolic, AtFBA5.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: T184C_MOUSE
Sequence: MPCACNRSNWRRWIRPLLVLFYATTILVAVPICIWKFQKMKVGMHTKSWFIAGIFLLLTIPVSLWGILQHLVHYTQPELQKPIIRILWMVPIYSVDSWVALVYPKIAIYVDTWRECYEAYVIYNFMIFLTNYLTIRFPNLILHLEAKDQQNHILPLCCCPPWAMGEMLLFRCKLGVLQYTVVRPITTVTALVCEILDVYDEGNFGFSNAWTYLVILNNLSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVLIALLVKLGVISEKRTWEWQSAEAVATGLQDFIICIEMFFAAIAHHYTFSYKPYVHEAEEGSCFDSFLAMWDVSDIRDDISEQVRRVGRTMRGYPKKKCFPGDPDHNEHSSLLSSSSQDLTSGSSKVPSPGGLYQGFGHTISSQSPISIASIYEEIMNDIPEEQQKLLNPGQDVTINIPEEQQKLIDKRKDVMIDIPEQNAIPDNSQYQDQEQIVTLQALFPSTETSENSMIDTSESQQESSDLCTESSDSSTESSDLSTDP
What is the function of this protein?
Possible tumor suppressor which may play a role in cell growth.
What are the official names of this protein?
Transmembrane protein 184C, Transmembrane protein 34.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYH_VIBVU
Sequence: MAKTIQAIRGMNDCLPTQSPLWQKLEGAVKNVISAYGYNEMRMPIVEMTHLFSRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIENGLLYNQEQRVWYMGPMFRHERPQKGRYRQFHQCGVEVFGLNGPDVDAELIMMTARLWRELGIDKHVRLELNSIGSLEARANYRTALIAFLEQHIDVLDEDCKRRMHTNPLRVLDTKNPDVQAILGDAPRLSDYLDPESTQHFAGLCELLDAAGIEYTVNERLVRGLDYYNRTVFEWITESLGSQGTVCGGGRYDGLVEQLGGKATPAVGFAMGLERLVLMLETLELTDVRRSVDVYVVTAGEGTMMAGMKLAEQVREAIPGVRVMNHFGGGNFKKQFKRADKVGAVVALVLGENEVADNTVVLKDLAGGEQVTYSQQEIASKIAELI
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1843_LACAC
Sequence: MKIIIAPAKIMKLDRDSFPVQSTPEFLKKTRILEKFLKSRTRDQLETLWHASDKVVEQSLFQLKNMDLDTNLTPAILAFSGIQYQYMAPDLFTQPALDYIQKNLRILSGFYGMLRPFDGICPYRLELNTKMVGFRDYSLYHFWDEDIANSLFKEDQVVINLASKQYMRLVKPYLNSARRMITVDFQELKNDKWKTVGVHAKMARGEMVRFMAEKQIKNPADLRDFHDFDFQFVPEVSSDDHYIFRTDFDFTRH
What are the official names of this protein?
UPF0246 protein LBA1843.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.