PharMolix/UniProtQA huggingface dataset:
Protein: PLCG2_RAT
Sequence: MTTMVNVDTLPEYEKSQIKRALELGTVMTVFSARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHKADCCFTIFYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEDPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFLVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLRLYQEKCNRRLREKRVSNSRFYS
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  It is a crucial enzyme in transmembrane signaling.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2.
Protein: RR3_CRUWA
Sequence: MGQKINPLGFRLGTTQSHHSLWFAQPKKYSEGLEEDKKIRDCIKNYVQKNIRISSGMEGIARIEIQKRIDLIQIIIYMGFPKLLIEDKPRRVEELQMNVQKELNCVNKKLNIAITRISNPYGDPNILAEFIAGQLKNRVSFRKAMKKAIELTEQANTKGIQVQIAGRIDGKEIARVEWIREGRVPLQTIEAKIDYCSSTVRTIYGVLGIKIWIFVDED
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OPGH_NITEU
Sequence: MNKTTEYIDALPLTVAEKATLPATDIRTLHETLNPEHHDYAREDDSPLGSVKARLEQSWPDSLVNRQLTEDDEGRTQLETMPKATRSSISPDPWRTNPIGRFWDHLRGHNATPHHVSRLTKEEQAHEQKWCTVGTIRRYILLLLTFSQTALATWYMKTILPYQGWALIDPIDMIGQDIWISFMQLLPYILQSGILILFAILFCWISAGFWTALMGFLQLLIGKDKYSISASLAGDVPINPEHRTALIMPICNEDVDRVFAGLRATWESVKATNQQQHFDIYILSDSYDPDICVAEQKAWIELLAEVQDKGQIFYRRRGRRVKRKSGNIDDFCRRWGSQYSYMVVLDADSVMSGECLTSLVRLMEANPNAGIIQSWPRASGMDTFYARCQQFATRVYGPLFTAGLHFWQLGESHYWGHNAIIRVQPFIEHCTLALLPGEGTFAGSILSHDFVEAALMRRAGWGVWIAYDLPGSYEELPPNLLDELKRDRRWCHGNLMNFRLFLVKGLHPVHRAVFLTGVMSYLSAPLWFMFLALSTALQVVHAFTEPHYFLQPHQLFPVWPQWQPELAIALLASTMVLLFLPKLLSILLIWCKGTKEYGGFIRVTISLLLEVILSVLLAPVRMLFHTVFVVSAFLGWKVAWKSPQRDDDSTTWREAFMRHGSQLLLGLVWATGMAWLDLRFLFWLAPIVFSLILSPFVSVFSSRASVGLRAKRWKLLLIPEEYSPPKVLVDTDNYLMMNRNRTLNDGFMHAVFHPSFNALTTATATARHRKSKVLEIARDHHIEQALNEPPDKLNRDCRLTLLSDPVIMSRLHYCVWAMPEKYASWVNHYQQLTLNPSALKQCEPNIEEEADYAEPTAQIDMALPGTP
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMM_SHEB2
Sequence: MSSNQQPVVLGKLGSCHGIKGWLKITAYTDSVEGIFDYSPWLIKENGEWREIKVTQWRYQGKAVVALLDGVETREQAQMLTNCEIAILPEQMNDLPADEFYWRDLIGCEVVNTTGYNMGIVDQIVETGSNDVLLVKANAKDSFGKVERMIPFVPEQFIKTVDLQGKQILVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROLC_CATRO
Sequence: MAEDDLCSLFFKLKVEDVTSSDELARHMKNASNERKPLIEPGENQSMDIDEEGGSVGHGLLYLYVDCPTMMLCFYGGSLPYNWMQGALLTNLPPYQHDVTLDEVNRGLRQASGFFGYADPMRSAYFAAFSFPGRVIKLNEQMELTSTKGKCLTFDLYASTQLRFEPGELVRHGECKFAIG
What is the function of this protein?
Hydrolyzes cytokinin glucosides thus liberating free cytokinins.
What are the official names of this protein?
Cytokinin-beta-glucosidase, Protein ROL C.
Protein: NRDR_STRU0
Sequence: MRCPKCNYNKSSVVDSRQAEDGNTIRRRRECEKCHTRFTTFERLEELPLLVVKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENLISRIEQKVRANYENEVSSTAIGNLVMEELAELDEITYVRFASVYKSFKDVDEIEALLQQITNRVRGKKKSSIDDETH
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RS23_FRAAN
Sequence: MGKTRGMGAARKLKNHRRRQRWADKSYKKSHLGNEWKKPFAGSSHAKGIVLEKIGIEAKQPNSAIRKCARVQLIKNGKKIAAFVPNDGCLNYIEENDEVLIAGFGRKGHAVGDIPGVRFKVVKVSGVSLLALFKEKKEKPRS
What are the official names of this protein?
40S ribosomal protein S23, S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FABA_ECO55
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGSEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4TH_SINFN
Sequence: MSDSIIVFDKVKKAYGNFTVINELDFEVRRGEKVSIIGPSGSGKSTVLRILMTLEGINDGAVYVGGEPLWHELKNGSMMPATEKHLRKMRTQLGMVFQQFNLFPHMTVLRNLTEAPRVVLGLSKEEARRRAEELLELVGLVDHAHKFPAQLSGGQQQRVGIARALAMRPKIMLFDEPTSALDPELVGEVLNVIRRLAAEHDLTMLMVTHEMRFAREISDRVCFFDKGRIREEGTPEQLFSQPKEERTREFLKAVLDG
What is the function of this protein?
Probably part of a binding-protein-dependent transport system y4tEFGH for an amino acid.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Probable amino-acid ABC transporter ATP-binding protein y4tH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SMOX4_SCHMA
Sequence: NHHLNNNIEYSDDKENCLNESLEYNHQIKLNKQNQNSFRNRTAFTDYQLICLEREFSHIQYLSRIDRIHLAQNLNLTEKQVKIWFQNRRVRWRKRNLF
What are the official names of this protein?
Homeobox protein SMOX-4.
What are the subcellular locations of this protein?
Nucleus.
Protein: DABA_LEGPL
Sequence: MSSHITLIKTNTNNENKMTQFNYKVDNDVMIIRAMVNNVAKQMTPVWPLEKFIACNALHGFESMSFEEAVIQNQTAKKGTPFNEKLERVNWHMIKWCGSFLDIGQGTLEMPHRDKGLYFGFLKLAPFDSALHQNSKSIKSWLSNLPEMPEQAIRLCLDNLGVLNQKQEDFLQSTLSHLPGWAGYIKWISEWKNRNGKEENPVSLVDFIAVRLVITCILWPEASQEEKKKKKDSADTKQLIQNIKNKEDNYRQLLLKKLLPELSKAHIKENRANAQMVFCIDVRSEPFRRCIEKLGHYETLGFAGFFGLPVSIKDYDGETIKDSCPVLLKPRFNIHEKAIAANEHCIEHHEKGKEFKNILNRVYQQLKYNFSTPFALVESLGIWCGITMFLKSCSPIFARRLTKDLNEMICPSIQTQPVFELDLLEKEVGISLQEQIAYAEMALRLMGLTDNFAKLVIFCGHGSSTQNNPYASALDCGACGGNQGGKNAQLLASILNKIIVRRALAENGINIPQDTLFYGAQHDTTTDEVEIYHSNVSQFIHQDILAQLRTDLNMAKYNNNLERINYLNSIDCAEKDIARRSTDWSETRPEWGLARNAAFIVAPRQLTKNINLEGRCFLHSYDWSQDKDGTLLETILTAPMVVAQWINTQYLFSTIDNVAYGSGSKITHNVAGKIGVMQGNASDLMHGLPLQSVMSHDEQSFHEPQRLLTVVYAPREIISELVEKHDVLKTLFFNEWVHLVAIDPRNHLFYKLEKTNTWSVIQ
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ENO_DESPS
Sequence: MSDIISAVDAMEVLDSRGNPTVRVFVTLDNGTTCAASVPSGASTGENEAIELRDGDASRYLGKGVLKAVDNVKNIIAPAVIGKKITHQAAIDNLMIELDGTETKSSLGANAILGVSMAVARAGARSSRLPLYQYLGGPGARRIPVPAMNIINGGEHADNSVDIQEFMAVPVGAPSFGEGLRYIAETFHNLKKILKSRGLATSVGDEGGFAPNLESNEAAMDIIIEAIEASGYTPGKDIAFALDSAASSFSPDLCGSYDLKWSGGGKKDSADMIAMAQKWIEKYPIVSWEDPLAENDWAGFQKLTAAVGDKIDVVGDDLFVTNTKYIARGIEEKSANSVLIKLNQIGTVTESIDAVRMCREAGWRYFISHRSGETEDTFLADFAVAMDGGQLKTGSASRSERIAKYNRLLEIERELGANALYYW
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ECM29_HUMAN
Sequence: MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNELKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERNADTLPDQEELIQSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLPIPSEGSGFTKLHLVESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVEAKQIELQFTIGEAITSAAIGTSSVAARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKHIISPNPHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQDQQELVSTLVETLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPDLVYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTDKSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPCLLDKGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLLQKLNGWYMEKEEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEKEECNLWTEVWQENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASIAKQTSSLVPPYLGMILTALLQGLAGRTWAGKEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSLESSGVRTTKNEEENEKEKELQLEYLLGAFESLGKAWPRNAETQRCYRQELCKLMCERLKLSTWKVQLGVLQSMNAFFQGLMLLEEEHADPEALAEILLETCKSITYSLENKTYSSVRTEALSVIELLLKKLEESKQWECLTSECRVLLIESLATMEPDSRPELQEKAALLKKTLENLE
What is the function of this protein?
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins.  May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome.  May play a role in ERAD and other enhanced proteolysis (PubMed:15496406).  Promotes proteasome dissociation under oxidative stress (By similarity).
What are the official names of this protein?
Proteasome adapter and scaffold protein ECM29, Ecm29 proteasome adapter and scaffold, Proteasome-associated protein ECM29 homolog.
What is the protein family that this protein belongs to?
Belongs to the ECM29 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle.
Protein: NFUA_XANCP
Sequence: MIQISDKAQTYFRKLIEREGVPGMGVRLSAVDAGTPRADAKLEFAEPADLSGDEWAIDCDGFTLYVVAASVPWMDGAEIDYVTQSTGNQQLTIKAPKIKGEAPAESASMVERVRWVVENEINPQLASHGGRVAVQEVSAEGVVLLRFGGGCHGCGMADVTLKQGIEKTLMGRLPGVIAVRDATDHATGDAPYIPRDSAA
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: CAPSD_CDDV1
Sequence: MARKYAKRSKSRPRTARRSPKSRSRPRSRAPRRKAPSRPRIQRVNPVRRPMNSTAAQSLAIYRNPFSHSPGQPKIPDGKAIMSIGSKVQVSAQLLNKASGDDILHVFLYPGLTQGMVVFGDSKEQGTRGFTAYGYNDHMTYDASSVYNAGTGADGNIESNDNINEWRLVSQGLKLSLLNTDEENDGWFECVRYKDALRANEFAFYSGDNLEQTTATVFGPDITFGSTLLTKNLVNSPTYVSGALEDIDKYEFKLQAQSEQHDFKRIPDRWYTEHGVDTVTVSGVNDYVTLQADTAQAHSIHNSLVDDSFDAVYIRIHCRTNSGAGATTGSKLLAHLVSNQELVYDEDQNEHKFMTQAAMAKAEFMKANEMARKSQVGADMIGNVRSGVRSQRRPR
What is the function of this protein?
Self-assembles to form the virion icosahedral capsid.
What are the official names of this protein?
Capsid protein.
What are the subcellular locations of this protein?
Host nucleus. Virion.
Protein: RS9_BRUMB
Sequence: MVESINSLEELGTVAKTEAAAPVDVQKLDAQGRAYATGKRKDAVARVWVKPGTGKITVNDKEFEKYFARPVLQMILQQPIVASNRAGQFDIVATVAGGGLSGQAGAVRHGISKALTYYEPGLRTVLKKGGFLTRDSRVVERKKYGKAKARRSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: ATPD_AMOA5
Sequence: MYTSNIQVASRYAKSLLKQAIDMGVLDHVYKDALFFKKVGKSHKTLFRVLHNPIIKNETKLAILTSIFQSRIHPLTFHLLKLLSHRKREGILPTIIDTFLEQYYIYRGIKAASVTTTFRLSDDLIRYFKNLAKSLVPCKEVILKEYVNPSIQGGFVLRIEDQQLDNSLATRLHKLKKQYSIAEY
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YHGP_ECOLI
Sequence: MFHDLPGVK
What are the official names of this protein?
Protein YhgP.
Protein: KHSE_NOSS1
Sequence: MSVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLEESGLIIQATGAEAERVPTDESNLIYQAFAKLYQYIDQPAPGVKIEIELGVPLARGLGSSATAIVAANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIVPVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQPYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVEAAMSTAWQEAGITAVVRSLALDTHGAT
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX5_DICDI
Sequence: MSKIVKFLKELATPSHSMEFFHKPASNSLLDASELNFVRRNIKREDFGHEVLTGAFGTLKSPVIVESIFHSRIVACEGGDGEEHDILFHTVAEKKPTICLDCGQVFKLKHISSEGEVMYY
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5, Cytochrome c oxidase polypeptide V.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PH4H_MOUSE
Sequence: MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAVSLIFSLKEEVGALAKVLRLFEENEINLTHIESRPSRLNKDEYEFFTYLDKRSKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEERKTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYTVTEFQPLYYVAESFNDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCHALQKIKS
What is the function of this protein?
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.
What are the official names of this protein?
Phenylalanine-4-hydroxylase, PAH, Phe-4-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: SYDP_ECOBW
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: VP3_ROTBN
Sequence: MKVLALRHSVAQVYADTQIYTHDETKDDYENAFLISNLTTHNILYLNYSVKTLQILNKSGIAAVEIQKMDELFTLIRCNFTYDYIDDIVYLHDYSYYTNNEIRTDQHWVTKTNIEDYLLPGWKLMYVGYNGNDTRGHYNFSFKCQNAATDDDAIIEYIYSNELDFQNFILKKIKERMTTSLPIARLSNRVFRDKLFKTLVSDHSRVVNVGPRNESMFTFLDHPSIKQFSNGPYLVKDTIKLKQERWLGKRLSQFDIGQYKNMLNVLTTLYQYYDMYHEKPIIYMVGSAPSYWIHDVKQYSDLKFETWDPLDTPYSDLHHKELFYASDVTKLKDNSILYVDIRTDRENADWKTWRKIVEEQTANNLNIAYKYLSTGKAKVCCVKMTAMDLELPISAKLLHHPTTEIRSEFYLIMDIWDSKNTKRFIPKGVLYSYINNTITENVFIQQPFKLRTLRNEYVVALYALSNDFNNREDVVKLVNNQKNALITVRINNTFKDEPKVGFKDIYDWTFLPTDFETNESIITSYDGCLGMFGLSISLASKPTGNNHLFILSGTNKYFKLDQFANHMSISRRSHQIRFSESATSYSGYIFRDLSNNNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSTNKASIEGGRYYEHAPIELIYACRSAREFAKLQDDLTVLRYSNEIENYINKVYSITYADDPNYFIGIKFKNIPYEYDVKVPHLTFGVLNISDSMVPDVVAILKKFKNELFRMDVTTSYTYMLSDEIYVANVSGVLSTYFKLYNAFYKEQITFGQSRMFIPHITLSFSNKRVVRIGSTRLNIDFIYLRKIKGDTVFDMTE
What is the function of this protein?
Counteracts the host innate immune response thanks to its phosphodiesterase that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell IFN-inducible 2',5'-oligoadenylate synthetase (OAS).  The host RNaseL is therefore not activated.
What are the official names of this protein?
Protein VP3.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP3 family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Protein: CBY1_HUMAN
Sequence: MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK
What is the function of this protein?
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors.  Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins.  Promotes adipocyte and cardiomyocyte differentiation.
What are the official names of this protein?
Protein chibby homolog 1, ARPP-binding protein, Cytosolic leucine-rich protein, PIGEA-14, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1.
What is the protein family that this protein belongs to?
Belongs to the chibby family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans- Golgi network.
Protein: ST1S3_DANRE
Sequence: MEISDFSSMKLNSRPELIDFEGISMIHYFTDNWEKVKNFQARPDDILIATYPKAGTTWVSYILDLLYFGNESPERQTSQPIYMRVPFLEACFEGIPFGTELADNLPTSPRLIKTHLPVQLVPKSFWEQNSKVVYVARNAKDNAVSYFHFDRMNMGQPEPGDWNTFLQKFMEGRNVFGPWYDHVNGYWKKKQTYSNILYMFYEDMVENTGREVERLCSFLGLSTSAAERERITKGVQFDAMKQNKMTNYSTIPVMDFKISPFMRKGKVGDWRNHFTVAQNEQFDEVYKQKMKNTTVKFRTEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including dopamine, T3 (triiodo-L-thyronine), T4 (thyroxine), estrone, DHEA (dehydroepiandrosterone), flavonoids, isoflavonoids and other phenolic compounds.
What are the official names of this protein?
Cytosolic sulfotransferase 3, SULT1 ST3.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_ECO7I
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSSLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWEGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPELDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.