PharMolix/UniProtQA huggingface dataset:
Protein: RL13A_MOUSE
Sequence: MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKMHYRKKKQILRLRKQAEKNVEKKICKFTEVLKTNGLLV
What is the function of this protein?
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:36517592).  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094).  Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).  In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).  Involved in methylation of rRNA (By similarity).
What are the official names of this protein?
60S ribosomal protein L13a, Transplantation antigen P198, Tum-P198 antigen.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_CHLAA
Sequence: MALSEAEVRHVARLARIALSDEEIALMQAQLSAILDYIAMLQEVDVSNVPPTAQVTGLTTVWRPDVVGEMLTQEQALANAPDQQDGMFRVRAVFDE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: CRVPA_NAJHA
Sequence: NVDFNSESTRRKKKQKEIVDLHNXLRRXVD
What is the function of this protein?
Inhibits calcium-activated potassium channels (KCa), voltage-gated potassium channel (Kv), and the calcium release channel/ryanodine receptor (RyR).
What are the official names of this protein?
Cysteine-rich venom protein annuliferin-a, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: SMY2A_DANRE
Sequence: MKKEGIEGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLTVNERGGRCECCFTRKEGLSKCGKCKQAYYCNVECQRGDWPMHKLECSAMCAYGENWCPSETVRLVARIILKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRHLDFPDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLYPTEDRIERLKDSYFFNCDCKECTSKSKDEAKMEIRQKLSIPPEEEEIKQMVIYARNVIEEFRRAKHYKTPSELLEICELSMEKMGAIFAETNVYMLHMMYQAMGVCLYMQDWDGAMKYGEKIIHPYSVHYPPYSLNVASMYLKLGRLYLGLEKRTQGVKALKKALAIMDIAHGKDHPYIDEIKKEMEEQT
What is the function of this protein?
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1.  Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo.  The activity requires interaction with HSP90alpha.  Shows even higher methyltransferase activity on p53/TP53.  Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.  Monomethylates RB1 at 'Lys-860'.
What are the official names of this protein?
N-lysine methyltransferase SMYD2-A, Histone methyltransferase SMYD2-A, SET and MYND domain-containing protein 2A.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RNH2_MYCBT
Sequence: MTKTWPPRTVIRKSGGLRGMRTLESALHRGGLGPVAGVDEVGRGACAGPLVVAACVLGPGRIASLAALDDSKKLSEQAREKLFPLICRYAVAYHVVFIPSAEVDRRGVHVANIEGMRRAVAGLAVRPGYVLSDGFRVPGLPMPSLPVIGGDAAAACIAAASVLAKVSRDRVMVALDADHPGYGFAEHKGYSTPAHSRALARLGPCPQHRYSFINVRRVASGSNTAEVADGQPDPRDGTAQTGEGRWSKSSHPATMRATGRAQGT
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAC_OSTTA
Sequence: MSHAVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKAGQIASAPRTEDCVGCKRCEAACPTDFLSVRVYLGSETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: C1QA_HUMAN
Sequence: MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA
What is the function of this protein?
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.  The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
What are the official names of this protein?
Complement C1q subcomponent subunit A.
What are the subcellular locations of this protein?
Secreted.
Protein: PFKA_DROME
Sequence: MNSEINQRFLARGSQKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEECDTDAVA
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_SCHMA
Sequence: MVHGNDVLHHNHFRKKWQFMVKTWFNQPARKERRRQARKAKAQRIAPRPASGPLRPIVNCPTFRYNMKVRSGRGFSLQEVRAAGLNPKFARTIGIAVDHRRRNVSVEGLQRNVARLKAYKAKLILFPLNPAKPQAMDAKADEVKKATQLRRPVLPITQRAKRLKAHKPTSSELRYSAFHAIRQQ
What are the official names of this protein?
60S ribosomal protein L13, BBC1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL13 family.
Protein: ACCD_XANC5
Sequence: MSWLSKLMPSGIRTENTPAKKRSVPEGLWEKCSNCGSALYGPELEENLEVCPKCDHHMAIRARARLNSLFDPDTATTEIAAQLGPVDALKFKDQKRYGERIKASQKASGEYDALIAMRGTLKGNPLVAAAFDFAFMGGSMGSVVGERFARAAEVALEVGCPFVCFSASGGARMQEGLFSLMQMAKTSAALGRLREAGLPYISVLTHPTTGGVSASFAMLGDINIAEPHALIGFAGPRVIEQTVRETLPEGFQRSEFLLDHGAIDQICDRHQLRDRIAELTAMMMRQPHPQDADAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCS2_ARATH
Sequence: MSMASLYRRSLSPPAIDFASFEGKQIFNEALQKGTMEGFFGLISYFQTQSEPAFCGLASLSMVLNSLSIDPGRKWKGPWRWFDESMLECCEPLEIVKDKGISFGKVVCLAHSSGAKVEAFRTNQSTIDDFRKYVVKCSTSDNCHMISTYHRQVLKQTGTGHFSPIGGYNAERDMALILDVARFKYPPHWVPLKLLWDAMDSIDQSTGRRRGFMLISRPHREPGLLYTLSCKDESWISIAKYLKEDVPRLVSSQHVDTIERILYVVFKSLPANFNQFIKWMAEIRRTEDVNQNLSSEEKSRLKLKQELLKQVQETKLFKHVDKFLSSVYEDNLPYVAAKVYCDGDEILSGYESDESCCKETCVKCIKGLGEEKVTVVAYPSGNDVFTALLLALPPQTWSGIKDQSLLQEMKQLISMVSHPTLLQQEVLHLRRQLEMLKRCQENKEDEELSAPA
What is the function of this protein?
Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants.
What are the official names of this protein?
Glutathione gamma-glutamylcysteinyltransferase 2, Phytochelatin synthase 2, AtPCS2.
What is the protein family that this protein belongs to?
Belongs to the phytochelatin synthase family.
Protein: COX1_CERSI
Sequence: MFVNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLALPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNQTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTISSMGSFISLTAVMLMVFMIWEAFASKREVSTVELTTSNLEWLHGCPPPYHTFEEPVYVNLK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UXT1_ARATH
Sequence: MGEMKSMQMGVIGALFLSVASSVSIVICNKALMTNLGFPFATTLTSWHLMVTYCTLHVAYKLNFFENKPIDMRTVVLFGLLNGISIGLLNLSLGFNSIGFYQMTKLAIIPFTVLLETLFLNKKFSQKIKFSLFLLLVGVGIASITDLQLNFVGSVLSLLAIATTCVGQILTNTIQKRLNVTSTQLLYQSAPFQAAILFVSGPFVDKYLTSLNVFSFHYSPIVVGFITLSCLIAVSVNFSTFLVIGKTSPVTYQVLGHLKTCLVLAFGYTLLHDPFTPRNIAGILIAVLGMLLYSYFCSVASKSKQASSDSTFLGKDRDTTPLLGQENENHHEAKKLDKHSPV
What is the function of this protein?
Nucleotide-sugar transporter that transports UDP-xylose and UMP in a strict counter-exchange mode.
What are the official names of this protein?
UDP-xylose transporter 1.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TILS_THET8
Sequence: MDVPAFRERLLRLAPKDPLVLAVSGGGDSVALALLVKEAGRQAVVAHLDHGLRPESPLDQAFVRALAERLGFPFFTERVEVARIAQARGENLEAVAREVRYAFLHRVAREVGARAILTAHTLDDQAETVLLQLLQGTARATGIREREGIVVRPLLAHTREELRAYLRARGEAWREDPTNQDPALDRNFLRLFVFPLLEERFPAAKRALARFAEARAEEEGVLERQAEARLLPDPRFFVPAFRAAPLLEAPLAVRRRALRRLLEKLGLRPEARLVLLLEEALRGRPQTLPGGVLARRKGGTLFLLPPRPRLPLPPGFRRPAPGDYLERPSGRKRLVDFLAEKGVPRELKPLWPVRAEGNRVVEVLGLYPPPPEEAHMAEALAEAASAFREGEVPVGAVLVLPGRVLRAHNRVEGLRDPTAHAEMLLLREAGPEARGGRLYVTLEPCLMCHHALAQAGVEVVYGAENLKEGALTRFGLPTRARGGVRERECAKLLRDFFARLREGCRSG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBH_LACLA
Sequence: MANKQDLIAEVAAKTGLTKKDSEKAVNAFGEVVTEFLAKGEKVQLIGFGTFETRERAAREGRNPQTGEAIKIAATVVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PB2_I96A3
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKKITEMIPERNEQGQTLWSKVNDAGSDRVMISPLAVTWWNRNGPVASTIHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQNCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKLNVHEGYEEFTMVGKRATAILRKATRRLIQLIVSGRDEQSIVEAIVVAMVFSQEDCMVKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFLNWGIEPIDNVMGMIGILPDMTPSTEMSMRGVRVSKMGVDEYSNAERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLINTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPIFNYNKTTKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: RS4_STRPC
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMVLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVDPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PORTL_EHV1V
Sequence: MSADSIEPKQKRLRYADANKGRKVERKNTPRFEATTGLQSPGEEEQISADGGWVLIHPTPKTMLFKEILMGELGYTEGQGVYNAIRSTEAAIRQIQTTILTNTLNATRYEDLAKDWQTHLDSRGVSAEEIAATYGMYSEGEAVRVAEQIFATWHRTLQMSLLDFVRSITACFSASEPDGTASFAKYIDWIACLGLIPLQRLKRAPGATVHPKLWRKLPTDVPSLESCVDERDLAGKLYVANSLLREGLEAVVELARCTASVAIMDYDRVNIFYHYTRREVVAIDSTTGKRGECLVLWQPIWKDGSVLFDSPLQRICGEVCNCHALREHAKLCQLLNTVPVKILVGRKKDEAQGPGWASKAVDKLMGEGEELHSSSAASRLVKLIVNMKSMRHIGDITETVRSYLNETSTNLLSGAQVDTSLPGFGQSGKTKQGGNMPVQEAFRTSVINGINGMLEGYVNNLFKTIEDLRTGNSGLLDQLRDRESEITHLREQLLRVSQAAADGSTQPGASSAALPGSGAKSGAGGLGHEVIDIRNLMGDDGYVANSFQSRYIPAYTADMERLSRLWDQELLRCFKMNRITNNQGQEMSVSYSNSSISLLLAPYFFSILRARHLGFLITHQEAYRSEEELCVAVFKKTRLEAYLTELSTLFVARVRNSIAALNSTKRDLPVNDNEAQSDEEQLGKPSDERYYEGRDRSASPQRDRGRNGRGYHKRRRFSNNYRRRSGLARDSSIRDRSQRGSRPTPLLHDHVGH
What is the function of this protein?
Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging.  Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid.  Binds to the molecular motor that translocates the viral DNA, termed terminase.
What are the official names of this protein?
Portal protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae portal protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: UBCP1_DROME
Sequence: MEVKEVVVIVKWSGKEYPVDLTDQDTVEVLRHEIFRKTQVRPERQKLLNLKYKGKTAADNVKISALELKPNFKLMMVGSTEADIEDACSLPDNIGEVVDDFDDADEREESVEHSAVYLAKVQRRVRDYKIKELAPPREGKKLLVLDIDYTLFDHRSPAETGTELMRPYLHEFLTSAYEDYDIVIWSATSMRWIEEKMRLLGVASNDNYKVMFYLDSTAMISVHVPERGVVDVKPLGVIWALYKQYNSSNTIMFDDIRRNFLMNPKSGLKIRPFRQAHLNRGTDTELLKLSDYLRKIAHHCPDFNSLNHRKWEHYHPKKNS
What is the function of this protein?
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (By similarity).  Recruited to the 19S regulatory particle of the 26S proteasome where it dephosphorylates 19S component Rpt1 which impairs Rpt1 ATPase activity and disrupts 26S proteasome assembly (By similarity).
What are the official names of this protein?
Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor Ublcp1.
Protein: GSA_GEOUR
Sequence: MNYSRSELLFQEAQKAIPGGVNSPVRAFKSVGTDPLFIEKASGSRIYDVDGNEFIDYVGSWGPMILGHCHPQVVAAVKSAVDNGCSFGAPTELEITLAEMVIEAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDKILKFSGCYHGHSDSLLVKAGSGAATFGVPDSPGVPQDFAKHTLTATYNDLESVNKLVAENKNQISCIIVEPVAGNMGTVPPREGFLEGLRSLCTEEGIVLIFDEVMSGFRVAYGGAQELYNVTPDMTTLGKIIGGGLPVGAFGGKKEIMSLLSPSGGVYQAGTLSGNPLAMTAGIETLKLLQTEGFYQDLDRKSDYVASGIAKAAKDAGFPIYSTRVGSMFCAFFSKKPVYDWTSAAACDTKAFAKYFRLMLDEGIYLAPSQFETAFVSIAHSTDDLDKTIAAAAKAFKSL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC6_YEAS8
Sequence: MVLQYPQNKILVLSDHPHNFSKTQFLQDLFHCSSTGISIVKDQTWENRYYKVHFDLYIDSCKDIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLHQFMIAAHRNTFVVLVNVNEEVEQDEIDELNEIWSNAFTNVIEFVNWKRSKPTVNHNDYGEKLGLDRIQEIIDTHDWLNCEVLPATKIREEIPNEMPLEQIIRNLQSARLKYKSIENSSEADAFANEMADELSRYL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: CAPSD_RMV
Sequence: MSYNITSSNQYQYFAAMWAEPTAMLNQCVSALSQSYQTQAARDTVRQQFSNLLSAIVTPNQRFPETGYRMYINSAVLKPLYESLMKSFDTRNRIIETEEESRPSASEVANATQRVDDATVAIRSQIQLLLNELSNGHGLMNRAEFEVLLPWATAPAT
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: ILVD_STAAB
Sequence: MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTLSSMFEAVGAFKKGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVENIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEAGGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSIKTFTGKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAVGHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPENLI
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ALDR_HUMAN
Sequence: MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols.  Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates.  Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586).  Reduces steroids and their derivatives and prostaglandins.  Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525).  Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426).  Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).
What are the official names of this protein?
Aldo-keto reductase family 1 member B1, Aldehyde reductase, Aldose reductase, AR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.