PharMolix/UniProtQA huggingface dataset:
Protein: RUVC_CHLSY
Sequence: MRALGIDPGTATMGWGIVEFNNGHLRLIDVGALTTPAGMPHPERLLQLYNGLRAIIERLRPDTAAVEELFFGKNVNTALTVGQARGVALLALAQAGIPVHEYKPLAVKQAVAGYGGADKRQMQEMVRLTLGLATIPRPDDAADALAIAICHAYTAPTLQRFGLS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RPOC_LEIXX
Sequence: MLDATTFDELRIGLATADDIRRWSYGEVKKPETINYRTLKPEKDGLFGEQIFGPSRDWECSCGKYKRVRFKGIVCERCGVEVTKSSVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDMAPKDLEKVIYFAAYMVIDVDEEGRHADMPGLENELRLESKTLSDQRDARVAERLQRLETDLAALEEEGAKADQKRRVKDTAEKEMGQLRKSFDEDIARLERVWESFRTLKVGDLKPEDADFNELLDRFGLYFEAFMGAEAIKRRLQAFDLNQEAELLREQIATGKGQKKIRAIKRLRVVSSFLATGNSPAAMVLDVVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLRRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGTGNRALKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIIVGPQLKLHQCGLPKQMALELFKPFVIKRLIDLSHAQNIKAAKRMVERSRPQVWDVLEEIIRERPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCAAFNADFDGDQMAVHLPLSVEAQAEARILMLASNNILKPSDGRPVTLPSQDMIIGLHHLTTVREGAEGEGRAFASVSEAIMAKDQGSLHLNATIKIRLDNYVPSDAADTGTEPVTAVVETTLGRALFNEALPVDYPYVEAVADKGQISAIVNALAERYPKVEVAAALDRIKDAGFYWGTRSGVTVSLSDILTPPNKPQIVAGYEKKAAKINSEFEKGLTTDLERRQELVKIWTEATNEVAEAMSANFPADNTINRMVTSGARGNWLQVRNIAGMRGLVNNPKGEIIPRPIISSYREGLSVAEYFIATHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREDDCGTTKGLDLPIATVDAEGVLTRDPNVENSVFARTLAADAVGTDGTVVAKAGEDVGDVLIDKLVAAGVVDIKVRSVLTCESAVGVCAACYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGSASADDITQGLPRVQELFEARTPKGASPIAEAAGRIVIEETDKSRKVILTPDNGDEPHVYPVLKRSTLLVEDRQQVELGQQLIVGTVDPKEVLRVKGVREVQKHLVGGVQGVYRSQGVPIHDKHIEVIVRQMLRKVTVVDHGDTDLLPGELVDRSRYNEINRGALQEGKKTASARQEVMGITKASLATESWLSAASFQETTRVLTQAAMEGKSDPLIGLKENVIIGKLIPAGTGLSRYRNVSVEATEEAKAERYPNRIFADDSAFSENDLSFVDFDSFSSDDYTPGTYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ECFA1_LACDA
Sequence: MSDNIISFDHVTFTYPDSPRPALSDLSFAIERGSWTALIGHNGSGKSTVSKLINGLLAPDDLDKSSITVDGVKLGADTVWEVREKVGIVFQNPDNQFVGATVSDDVAFGLENRAVPRPEMLKIVAQAVADVGMADYADSEPSNLSGGQKQRVAIAGILAVKPQVIILDESTSMLDPEGKEQILDLVRKIKEDNNLTVISITHDLEEAAGADQVLVLDDGQLLDQGKPEEIFPKVEMLKRIGLDIPFVYRLKQLLKERGIVLPDEIDDDEKLVQSLWQLNSKM
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NU4LM_NYCCO
Sequence: MPLISTNILLAFITALLGVLIYRSHLMSSLLCLEGMMLSMFILVSLTTMNLHFTLANIAPLILLVFAACEAAVGLALLVMVSNTYGMDYIQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YQHA_ECOSE
Sequence: MERFLENAMYASRWLLAPVYFGLSLALVALALKFFQEIIHVLPNIFSMAESDLILVLLSLVDMTLVGGLLVMVMFSGYENFVSQLDISENKEKLNWLGKMDATSLKNKVAASIVAISSIHLLRVFMDAKNVPDNKLMWYVIIHLTFVLSAFVMGYLDRLTRHNH
What are the official names of this protein?
UPF0114 protein YqhA.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXK_ECOUT
Sequence: MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAIAGIGHPPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLAQLTSLASGH
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: METE_SERP5
Sequence: MAILNHTLGFPRVGLRRELKKAQESYWAGNSTQEELLAVGRELRARHWQQQQQAGVDLVPVGDFAWYDHVLTTSLLLGNVPARHQNADGTIDLDTLFRLGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFHKGQQFKLGWSQLLDEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDRLSLLNDILPVYQQVLAELAKRGVEWVQIDEPALVLELPQAWLNAFKPAYDALQGQVKLLLTTYFDSVGHNLDTLRELPVQGLHVDLVGGHDDIAVLNKALPKEWLLSLGVINGRNVWRADLSNWFERLQPLVGSRPLWIGTSCSLLHSPIDLSVETRLDEEVKSWFAFALQKCGELALLSAALNAPGAAKQAELDAYSAPIRARRQSSRVHNAQVGQRLAAITAQDSERQRPYAERAQAQRERFNLPAWPTTTIGSFPQTTEIRGLRLDFKQGRLDGNNYRTSISEHIKQAIVEQERLGLDVLVHGEAERNDMVEYFGENLDGFVFTQNGWVQSYGSRCVKPPVIIGDISRPEAITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTREVIAKQIALALRDEVEDLEKAGIGIIQIDEPALREGLPLRQSDWAAYLNWAVDAFKLNAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMDLLEAFKEFEYPNEIGPGVYDIHSPNVPSVEWIEALLRKAAQNIPAERLWVNPDCGLKTRGWPETRQSLANMVLAAQRLREQQA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: HIS4_BUCCC
Sequence: MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGSKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASKCWLKE
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXM3_ARATH
Sequence: MAISSSSSSICFNPTRFHTARHISSPSRLFPVTSFSPRSLRFSDRRSLLSSSASRLRLSPLCVRDSRAAEVTQRSWEDSVLKSETPVLVEFYTSWCGPCRMVHRIIDEIAGDYAGKLNCYLLNADNDLPVAEEYEIKAVPVVLLFKNGEKRESIMGTMPKEFYISAIERVLNS
What is the function of this protein?
Thiol-disulfide oxidoreductase required for maintaining symplastic permeability in the meristem.  Involved in redox regulation of callose deposition, plasmodesmata cell-to-cell communication and meristem maintenance.
What are the official names of this protein?
Thioredoxin M3, chloroplastic, AtTrxm3, Protein GFP ARRESTED TRAFFICKING 1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant M-type subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: CEL61_MYCTT
Sequence: MSKASALLAGLTGAALVAAHGHVSHIVVNGVYYRNYDPTTDWYQPNPPTVIGWTAADQDNGFVEPNSFGTPDIICHKSATPGGGHATVAAGDKINIVWTPEWPESHIGPVIDYLAACNGDCETVDKSSLRWFKIDGAGYDKAAGRWAADALRANGNSWLVQIPSDLKAGNYVLRHEIIALHGAQSPNGAQAYPQCINLRVTGGGSNLPSGVAGTSLYKATDPGILFNPYVSSPDYTVPGPALIAGAASSIAQSTSVATATGTATVPGGGGANPTATTTAATSAAPSTTLRTTTTSAAQTTAPPSGDVQTKYGQCGGNGWTGPTVCAPGSSCSVLNEWYSQCL
What is the function of this protein?
Enzyme involved in the degradation of lignocellulosic biomass.  Hydrolyzes weakly barley beta-glucan, carboxymethyl cellulose, lichenan, wheat arabinoxylan and birchwood xylan.  Stimulates the hydrolysis of lignocellulosic substrates (such as hydrothermal pretreated wheat straw or steam-pretreated spruce), when combined with other cellulolytic enzymes.  Lignin is a significant source of reductant residues that probably stimulate GH-61 activity by acting as electron donors.
What are the official names of this protein?
Polysaccharide monooxygenase Cel61a, Cellulase-61a, Cel61a, Endoglucanase-61a, Glycoside hydrolase-61, GH-61.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 61 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMG_CAMC1
Sequence: MKNELCLPAVFDEKVKAYAQIFTKFNKVHSLSNYKDISEQVLDSIKPLEIFDLSAKTAIDVGSGAGFPAIFLALAMPQTKWHLFEPIAKKSSFLSYAKIELGLQNLEVHSQKIELADKFTADLITSRALSKTKELIKICEGFYDENTKFLIYKGSSVMEEISGIDAQIYNEKNRNYIYFNLKNQGEIR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_UREPA
Sequence: MAKIKLLSIDGNFAKELEVTSDLFVEVPHKQAMFDSVLAENAAERQGTHSTLTKGEVRGGGKKPWRQKHTGKARTGSTRNPHWTGGGVVFGPKPNRNYNLKVNAKVRLLAFKSALTIKLNEGKMLGLVANSDLETPSTKKMVNFINNANLENQKVLLVIVDNFSNIKKSTNNLQKVTTKLWYQVSVRDLMHANVVVVAEEAFTNYARKVSK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HAP40_RAT
Sequence: MAAGSASSLGGGSWPGSEAGDFLARYRQVSNKLKKRFLRKPNVAEAGEQFAQLARELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQECDARQRLGCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRAVGQPAAAAGHFQRAAQLHLPLMPLAALQALGDAASCQLLARDYTGALAVFTRMQRLAREHGGHPVQQPELPQQLPSVPQPSLPGPQPRPVLGSTLPLPLPPDHAPGSVAQSPGTLGAFADVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDGHGQDSSGQLPEELFLLLQSLVMAAHEKDTEGIKKLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV
What is the function of this protein?
RAB5A effector molecule that is involved in vesicular trafficking of early endosomes.  Mediates the recruitment of HTT by RAB5A onto early endosomes.  The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility.
What are the official names of this protein?
40-kDa huntingtin-associated protein, Factor VIII intron 22 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (By similarity). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (By similarity). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity).
Protein: ESR22_CARAU
Sequence: MSSSTGPAPASASPVQANRGNSPNILPLLYTSQLGMDSQTICIPSPYVEACQDYSPPHGGEISHGALTLYSPVSSPVLGYTHPPVSESLVPLNSAIFWPPHPTHSTPSLHCPSPLAYRETHAHTTWEDAKTHINQSSSVLTHAKLLGQQLDGDDGLNPSPGILGKGDTHFCAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGGRHRRNPPIRDSSGGAIGVRGHSQPHLEFPLSPTHPLFPLGDRAEGCGQNLSPEQLVNCILEAEPPQIYLREPIKKPYTEASMMMSLTNLADKELVLMISWAKKIPGFVELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFSPDLKLNRDEGTCVEGIMEIFDMLLATTSRFRELKLQREEYVCLKAMILLNSSNCSRLPQTPEDVESRGKVLRLLDSVTDALVWTISRTGLSSHQQSIRLAHLLMLLSHIRHLSNKGIEHLSTMKRKNVVLLYDLLLEMLDANTSQSSRMLAAHTKASLRMDTQQTTEILHTSKQQPALKESNQDTRHSPQAEGTVDKTLHRVDKTLHRVDVDTD
What is the function of this protein?
Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
What are the official names of this protein?
Estrogen receptor beta-2, ER-beta-2, Nuclear receptor subfamily 3 group A member 2-B.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH_MYCUA
Sequence: MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDDCAFPLLSGVEIGSDANKIFDGANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGVAVTDIKKMTIWGNHSATQYPDLFHAEVKGKNAAEVVNDQAWIEEYFIPTVAKRGATIIDARGASSAASAASASVDAARSWLLGTPADDWVSMAVLSDGSYGVPEGLISSFPVTTKDGNWSIVKGLEIDEFSRGRIDKTAAELADERKAVTELGLI
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: NHAB_PSEPF
Sequence: MSGSMAQAFAHNFLGHSPRWYKACIVGFLMLNALVLWSVGPVAAGWLLVIEFIFTLAMALKCYPLMPGGLLLIEALLLKMTTPQALYEELQHNFPVILLLMFMVAGIYFMKDLLLFLFSRLLLGVRSKALLALMFCFLSAFLSAFLDALTVTAVIISAAVGFYSVYHRVASGNDPRQDSEFSDDQHLPQLHHEDLEQFRAFLRSLLMHGAVGTALGGVCTLVGEPQNLLIGHEMGWHFAEFFLKVAPVSLPVLVAGLVTCLLLEKLRWFGYGTLLPDNVRAVLANYAAEDNAERTPRQRAALLVQGCAALILIAGLAFHIAEVGLIGLMVIVLITAFTGITDEHRLGSAFKDAMPFTALLVVFFAVVAVIHDQQLFAPLIQWVLALPADQQPGMLFIANGLLSAISDNVFVATIYITEVKQAFLSGHMSREHFETLAIAINTGTNLPSVATPNGQAAFLFLLTSAIAPLVRLSYGRMVWMALPYTVVMGLLGWYAVSYWL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YR844_MIMIV
Sequence: MSDMYHQLPPEIWVKIMDHLKEVSLLLTNKDFFGLFNLIDVEKNMIEHIVENGYLDVLKYIDSLKNQNKFIVDKEKFSVKSLDKYLIMSCEFGHLEMTKYFVSQGANVKTDNNMPLRLASQNGHIDTIKYLIENSVDVRANNDCALRMASLFGHINVVKYLVDMGADVTSDNNFAIIHTARSGRLELAKYLAEKGADIRASNDSAVIRASERDI
What are the official names of this protein?
Putative ankyrin repeat protein R844.
Protein: PNP_CLOBA
Sequence: MNNVLSTNIAGKEMKVEFGKIGMLSNAATFMSYGDTVILTNVNASSEPRVGIDFFPLSVEYEERLYAVGKIPGGFIKREGRPSEKAILNGRAVDRTLRPLFPKGYRNDVQVVCTVVSVEKDNLPEILAINAASMALCLSSIPFAMPVAAVQVGLIDNNFIVNPNATEREESTLHLTVCATKERVMMIEAGGNEIPEDIMIAAIKFGFDECQNIINFQEEAVKKFGKEKDIPTLFTVDEEVEKDIKEFASDMIKEAMYITDKDERNAAIDAVNQKVKEEFGEKYEDKFGDIKEVLYNMQKKVVRHMLLKDKRRPDGRAFDQVRPLGCEVGLLPRTHGTGLFTRGLTQVMTVATLGAVGDIQILDGIDEAQSKRYMHHYNFPGYSVGEVKPLRGPGRREIGHGALAERALEPLIPSEEEFPYTIRLVSEVLSSNGSTSQASVCGSTLALLDAGVPLKRPAAGIAMGLITSEDLSEEQVLTDIQGIEDFFGDMDFKVAGTTEGITSIQVDTKLKGFSFNVVENAIRDARKARMTILEKINECISSPREDVSLYAPKTETIQIDPDKIRSVIGAGGKVINKIIQDTGVKIDIKEDGSVFVSSSDHEGVKEAIKIIEGLTKDVKAGEIYLGKVTKITTFGAFVEILPNKEGLVHISKLDKERVNKVEDVVSVGDEILVKVTEIDSQGRINLSRKDVLLDQENKENKEEK
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEP1_PODAN
Sequence: MRFSLALAAAGLAQTAFAAPQPSRGFGCGAPEPSEELLQVSQQFAVEEAQALAESYRSGNLTARDVTAQAISVKVYIHVVAASTALSGGYLTDTMINNQFSVLQSAFAPYGISFTLAGTDKTVNANWADDSKGYEMTMKRALRKGTYKDLNLYFLQKMGGNLGYCYFPTTASPGSTAYIRDGCTILYSTTPGGSSTNYNLGHTATHEVGHWFGLYHTFQGGCTGAGDSVSDTPAQASASSGCPVGRDSCPSQAGVDPIHNYMDYSIDSCYEEFTPGQQTRINSFWTSYRQNAS
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Extracellular metalloprotease PODANS_2_14170.
What is the protein family that this protein belongs to?
Belongs to the peptidase M43B family.
What are the subcellular locations of this protein?
Secreted.
Protein: NODA_BRADU
Sequence: MNIAVSPTAEGSSGRAQVQWSLRWESELQLADHAELAEFFRKSYGPTGAFNAQPFERSRSWAGARPELRVIGYDARGVAAHIGLLRRFIKVGEVDLPVAELGLYAVRPDLEGHGIGHAMRVMYPALQELGVPFGFGAVRSALEKHLTRLVERQGLATLMRGIRVRSTLPDVYPNLSPTRIEDVIVVVFPVGRSISEWPAGTVIDRNGPEL
What is the function of this protein?
N-acyltransferase required for nodulation.  Acts in the production of a small, heat-stable compound (Nod) that stimulates mitosis in various plant protoplasts.
What are the official names of this protein?
Nodulation protein A.
What is the protein family that this protein belongs to?
Belongs to the NodA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_BARBK
Sequence: MSDLVKTALSLVPMVVEQTNRGERAYDIFSRLLKERIIFINGPVEDSMAMLVCAQLLFLEAENPKKEISLYINSPGGVVTSGMAIYDTMQFIRPPISTLCMGQAASMGSLLLTAGAKGHRFSLPNARIMVHQPSGGFQGQASDIERHAQDIIRMKRHLNEIYVQHTGQDYEIIENTLDRDHFMTAEEAKMFGLIDDVIQYRAETKKEEKD
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLB_BORPE
Sequence: MSACPAPRSPVRWLHAFTLFLLLAVLAGCVSVPKPMAGAGEDVFSRVGRFAITVTESDGKQQAVQGGFAWRDDGGSYLLDLTNPLGSTEARVEGRPGMAVLTRANGERLAAEHPDALAEDALGSPVPVTGLRDWLRGRLMAGAAPDGLERDAQGRPTAFEQDGWNARLSRYDAQGPQLLVLQRQEPGRRILVRLVITQP
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RU2A_MACFA
Sequence: MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.
What are the official names of this protein?
U2 small nuclear ribonucleoprotein A', U2 snRNP A'.
What is the protein family that this protein belongs to?
Belongs to the U2 small nuclear ribonucleoprotein A family.
Protein: PANX2_MOUSE
Sequence: MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTVRVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLNKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDTTPTVRDSGIQTVDPSINPAEPDGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAIMRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDSGPSSAPPAASEKKHTRHFSLDVHPYILGTKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAPLPEKEIPYPTEPALPGLPSGGSFHVCSPPAAPAAASLSPGSLGKADPLTILSRNATHPLLHISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF
What is the function of this protein?
Structural component of the gap junctions and the hemichannels.
What are the official names of this protein?
Pannexin-2.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: VF345_ASFP4
Sequence: METFVCLFKDSPQQRSDAWHAVRHTQVGGSDLASILGLNPYKSYYITLAEKANLFKKNLNRAACSWGTLFERVSKDLLELFCQTTVIGDNIHIDGTYLGYPGHSNSPDGFCYLTLGYTQQSWEIKTIFNNVCYEATKRIPVLVEIKSPYNRKIKNSVPSYYMPQIQSGLALSPPISMGIYVEAMFRVCGIHQLGWNSETNIDIHPPESMLPLAWGIITICSTQEHTEAPQDFGTLDAETFRQLLETLYQKDQYTIHYSMPYETACPEMPNVVGYFGWKVFIFQIIPVMKHPQFLKDKYPIIQQFLRDLHTIKASPSPMETYEKICCSEESPLSTEDIDNFTDMLT
What is the function of this protein?
Plays a role in the negative regulation of host NF-kappa-B signaling pathway.  Mechanistically, recruits IKKA/CHUK and IKBKB to suppress their kinase activity towards NFKBIA.
What are the official names of this protein?
Protein D345L, pD345L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus D345L family.
Protein: APOE_RAT
Sequence: MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RL14_ALBFT
Sequence: MIQVESRLEVADNTGAKSVLCIKVLGGSKRRYASVGDVIKVSIKEAAPRGRVKKGEIYSAVVVRTAKGIRRSDGSLVKFDGNAAVLLNAKLEPIGTRIFGPVTRELRTEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.