PharMolix/UniProtQA huggingface dataset:
Protein: FTSK_CALS4
Sequence: MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALLLVFALMFLFTNKNFIKLHRSMALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNTGGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDISLVSLIKSSYDKLKDRKKVSAKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGEYTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPSAGVKVSRIVSLTDDLALSLAAPSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFRSFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKSVCINSLIVSLLYKASPKQVKMILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESYNEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVITGVIKANIPSRISFAVSSQIDSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISEEEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELLEDAVSVILETGQASISLLQRKLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: AMOL1_BOVIN
Sequence: MLMLHVKRNTCEHTFKCPPPACYSPSSPVQILEDPSYFFPDFQLYPGRHEASLTVEANSSIREKVVEDPLCNFHPPNFPRIPEVEMRGSEDAAAGTVLQRLIQEQLRYGTPTENMNLLAIQHQATGSAGPAHPTNFSSTENLAQEDPQMVYQSARQEPQGQEHQVDNTVMEKQVRSAQPQQNNEELPTYEEAKAQSQFFRGQQPPPPPPQQQPGAVGHSYYMAGGASQKARTEGRPTVSRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAKQHLPGPGNGKAFKAGGGPSPAQPAAKMLDPRGPPPEYPFKTKQMVSPVSKTQEHGLFYSDQHPGLLHEMVKPYPAPQPARTEVAVLRYQPPPEYGVTSRPCQLPFPSTAQQHSPVSSQNSSVSGPLHSVPLPLAPPMALGAAPPPPAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRLHDFNRDLRDRLETANRQLSSREYDGHEDRAAEGLYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNSQPASLPEYNAPALMELVREKEERILALEADMTKWEQKYVEESAIRHFAMSAAATAAAERDTTIVNHSRNGSYGESSLEAHIWQEEEEVVQATRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEERKEEKTWKGSIATGLLLGKEHNDHASTPLLPTPSAATLSPPTPGTSASSAHAKTGSKDSSTQTDKSAELFWPGVASLPTRSRLSGTPSNSPVLKHPAAKGTAEKLENSPGHGKSPDHKGRVSNLLHKPEFPDGEMMEVLI
What is the function of this protein?
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
What are the official names of this protein?
Angiomotin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the angiomotin family.
What are the subcellular locations of this protein?
Cell junction, tight junction.
Protein: A411_LOXHI
Sequence: WIMGHMVNEIYQIDEFVDLGANSIETDITFDDNAMEEYSFHGVPCDCRRYCHKWEYTNTFLDGLRRATTPGDSKFRKELALVVFDLKTGDLSSSTANKGGKLFGQKLLQHYWKGGNNGGRAYIILSIPDLDHYAFISGFKEALKTAGHEELLAKVGYDFSGNDDLGSTRTALNKAGVKDREHVWQSDGITNCVSTLFRGLDRVKKAVSNRDSSNGYINKVYHWTVDKYGSVRDALDAGVDGVMTNDPDVIVNVLNESKYKGKLRLATYDDNPWETFKP
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LhSicTox-alphaIV1i, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYR_VIBCH
Sequence: MNIQALINDRVSQAIEAAGAPAGTPALVRQSAKAQFGDYQANGIMGAAKQLGTNPREFAQKVLDVLNLEGIASKTEIAGPGFINIFLSEEFLAAQAEAALADARLGVAQEAPKTIVADYSAPNVAKEMHVGHLRSTIIGDAVVRTLEFLGHKVIRANHIGDWGTQFGMLIANLERVQKASGEVSMELSDLEAFYRESKKLYDEDEQFAETARNYVVKLQGGDPFCLEMWKKLVDVTMIQNQRNYDRLNVSLTRENVMGESMYNDMLPQIVSDLKAKGLAVEDDGAQVVFLEEFKNKDGEPMGVIIQKRDGGFLYTTTDIACAKYRYETLGADRVLYFIDSRQHQHLMQAWTIVRKAGYIPENVSLEHHAFGMMLGKDGRPFKTRAGGTVRLADLLDEAQERAKALIESKNPELSAEEKANIANTVAMAAVKYADLSKHRTTDYVFDWDNMLAFEGNTAPYMQYAYTRVASVFAKAGVDMNELTGHIQITEEKEKALIAKLLQFEEAVQSVAREGQPHIMCSYLFELAGIFSSFYEACPILVAEQESIKQSRLKLAALTAKTIKQGLALLGIDTLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAOP1_ARATH
Sequence: MEKVTNSDLKSSVDGGVVDVYGEDSATIEHNITPWSLSVSSGYSLLRDPRYNKGLAFTEKERDTHYLRGLLPPVVLDQKLQEKRLLNNIRQYQFPLQKYMALTELQERNERLFYKLLIDNVEELLPIVYTPTVGEACQKFGSIFRRPQGLFISLKDKGKILDVLKNWPERNIQVIVVTDGERILGLGDLGCQGMGIPVGKLALYSALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQKRATGQEYSELLNEFMSAVKQNYGEKVLIQFEDFANHNAFELLAKYSDTHLVFNDDIQGTASVVLAGLVSAQKLTNSPLAEHTFLFLGAGEAGTGIAELIALYMSKQMNASVEESRKKIWLVDSKGLIVNSRKDSLQDFKKPWAHEHEPVKDLLGAIKAIKPTVLIGSSGVGRSFTKEVIEAMSSINERPLIMALSNPTTQSECTAEEAYTWSKGRAIFASGSPFDPVEYEGKVFVSTQANNAYIFPGFGLGLVISGAIRVHDDMLLAAAEALAGQVSKENYEKGMIYPSFSSIRKISAQIAANVATKAYELGLAGRLPRPKDIVKCAESSMYSPTYRLYR
What are the official names of this protein?
NADP-dependent malic enzyme 1, AtNADP-ME1, NADP-malic enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIF2C_XENLA
Sequence: MERLVATRLVTGLAVKIMRSNGVIHNANITSVNMDRSSVNVEWKEGEANKGKEISFADVISVNPELLDAVLAPTNVKENMPPQRNVSSQNHKRKTISKIPAPKEVAAKNSLLSESGAQSVLRERSTRMTAIHETLPYENEMEAESTPLPIQQNSVQARSRSTKVSIAEEPRLQTRISEIVEESLPSGRNNQGRRKSNIVKEMEKMKNKREEQRAQNYERRMKRAQDYDTSVPNWEFGKMIKEFRATMDCHRISMADPAEEHRICVCVRKRPLNKQELSKKEIDIISVPSKNIVLVHEPKLKVDLTKYLENQAFRFDFSFDETATNEVVYRFTARPLVQSIFEGGKATCFAYGQTGSGKTHTMGGDFSGKSQNVSKGVYAFASRDVFLLLDQPRYKHLDLDVFVTFFEIYNGKVFDLLNKKTKLRVLEDAKQEVQVVGLLEKQVISADDVFKMIEIGSACRTSGQTFANTSSSRSHACLQIILRRGSKLHGKFSLVDLAGNERGVDTASADRITRMEGAEINRSLLALKECIRALGQNKSHTPFRESKLTQILRDSFIGENSRTCMIAMLSPGFNSCEYTLNTLRYADRVKELSPQNAETNDDNLQMEDSGGSHASIEGLQLQDDFLLKDEELSTHNSFQDALNRVGELEDKAVDELRELVQKEPEWTNLLQMTEQPDYDLENFVMQAEYLIQERSKVLIALGDSINSLRLALQVEEQASKQISKKKRSNK
What is the function of this protein?
Promotes ATP-dependent removal of tubulin dimers from microtubules.  Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:8548824).  May play a role in chromosome congression and may be required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity).
What are the official names of this protein?
Kinesin-like protein KIF2C, Kinesin central motor 1, xKCM1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Protein: RDXA_HELPH
Sequence: MKFLDQEKRRRLLNERHSCKMFDSHYEFSSTELEEIAEIARLSPSSYNTQPWHFVMVTNKDLKKQIAAHSYFNEEMIKSASALMVVCSLRPSELLPHGHYMQNLYPESYKVRVIPSFAQMLGVRFNHSMQRLESYILEQCYIAVGQICMGVSLMGLDSCIIGGFDPLKVGEVLEERINKPKIACLIALGKRVAEASQKSRKSKVDAITWL
What is the function of this protein?
Reduction of a variety of nitroaromatic compounds using NADPH as source of reducing equivalents; two electrons are transferred.
What are the official names of this protein?
Oxygen-insensitive NADPH nitroreductase.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
Protein: E41LB_HUMAN
Sequence: MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFPAGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVSYPLPSPVLSSSDRLPFGIEENGGTPFLTAASGRHHHQHQHQHQHQHHSNYSLSLTLENKEGPLRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLELETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNIQGGKEESPFVNINKKSSLQDASVRSPIPIRVETAQPAVEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVSSPHKSEGKGLLSPGAKSPSDRGGAFTLEPGDLLMDFTEATPLAEPASNPHCAHSRCSPPLSLPMKEETTGVCMYPPIKTRLIKTFPVDTMNPFPDTFTTGPQFTADFRDSKLQCCPGPTSPLIPAATLRPLTETVSTVQTIYTTRKPVSLAASAETLRQELEREKMMKRLLMTEL
What is the function of this protein?
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity).  Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).  Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528).  May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).
What are the official names of this protein?
Band 4.1-like protein 4B, Erythrocyte membrane protein band 4.1-like 4B, FERM-containing protein CG1, Protein EHM2.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, tight junction. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner.
Protein: DPOL_HHBV
Sequence: MPQPLKQSLDQSRWLKEAEIKLRELENLVDSNLEDERLKPQLSMGEDVLSPEAGDPLHPNVRAPLSHVIGETRHDPPHLGNRDPARHKLGKLTGLYQMKGCEFNPHWKIPDISATNFSQEIINECPSRNWKYLTPAKFWPKSISYLPVHSGVKPKYPEFQQNHESLVNDYLNKLFEAGILYKRVSKHLVTFKGPYFTWEQKHLVPQQHGAYSSKINDRQESRRRRIITATSSRKNDSSRIFGAHNNGRKISYHSTRDGSHRLSGRTSDPTSRGALAGGDSTPIGPGSTAAHPSTHHVDRRRRQKGQGVLQAISREPSETRRNGTTSHHRVARCRTSSVEDFTRRPFTQSKGAYPRQGTRGTDPQGPKAHQQEENGSYLRGNTSWPNRVTGRIFLVDKNSRNTEEARLVVDFSQFSKGKNAMRFPKYWCPNLTTLRRILPVGMPRISLDLSQAFYHLPLAPASSSRLAVSDGKQVYYFRKAPMGVGLSPFLLHLFTTAIGAEIASRFNVWTFSYMDDFLLCHPSARHLNTISHAVCTFLQEFGIRINFDKMTPSPVTTIRFLGYEISKQHMKIEESRWNELRTVIKKIKVGQWYDWKCIQRFIGHLNFVLPFTKGNIEMLKPMYDACTHRVNFAFSSRYKILLYKLTMGVCKLTLDPKVSLPLPRVATDATLTHGAISHITGGSAVFTFSKVRDIHIQELLMVCLAKLMIKPRCILTDSTYVCHRKFSKLPWHFAMYAKQLLTRLTLYYVPSKYNPADGPTRHKPPDWTAVTYTPLSKHIYIPHRLCGL
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery (By similarity).
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: NKAP_DROME
Sequence: MRSRSRSRSRQRERRRSDSRARSRSERRTYQKPQHRRSVSRERKRERDRELHRERTSNRSSRRSREKDAVPRRRRTRSSPSRSSSSSSSDRSSSSRSPSRSRKSRPKSVERWPNDRYHENNDRRQNPFRGRAPEGSFINDPAEPSFRSQHRGRGSSNHQFKGDSKAVNARRNQRVLIGEEGVPEVWGKSPSRPETDDVELVKGSYIGPKKKKKKGKRKHKKSEKKSKKKSKKSKKKKSKQESSSSSSSSSSEDSSDESSSSSSSSSSDSEDESEEEDVWLEKTADGIKKPKKKKSSTSKKDKKSKKKKKKRKSEAEKSKKSSSSSASKSKNKESASHNDEDVGPSLRPGGSLNQKDFGKALLPGEGAAMAAYIAEGKRIPRRGEIGLTSDEIANFESVGYVMSGSRHRRMEAVRIRKENQLYSADEKRALAMFSKEERQKRENKILSQFKDMIHSKLQAKDKK
What are the official names of this protein?
NKAP family protein CG6066.
What is the protein family that this protein belongs to?
Belongs to the NKAP family.
Protein: PYRG_BURCM
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVISVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHASLHTSTRVNIEYIDSEEIEANGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYARESKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDSETPERVVALITEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFVPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAAFANKQARGVKA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: UPPP2_BURO1
Sequence: MSLWFLVFLSVLQGVTELFPVSSLGHTLLVPALFGMHIDKHAPQLLPFLVALHLGTALALLWYFRARWIALIGGFFAQLGGRKNDDGHLMWALIIGTIPTGIVGLLLEKRIERVFHDLRIVAIALIVNGVLLWLGDRIQRSRAHQAPEKMTFKQAFFVGLAQIGALIPGFSRSGLTMIAGNVAGLTAEKAAEFSFLLGTPIIFAAGVLELPKLFHARDQLADALLGGVLTAIAAYLSVRFLMRYFEGRGRLASFGVYCVIAGVFCLGWFMLHPQPV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
Protein: IF6_METBU
Sequence: MIKTVNIYDNPVLGVFATCTEDVAIVPIGTAGKAIDLLAEQLDVKVISTLINGSIVVGSLSKGNSNGFLISRDANVSDLKDVEVPVEVLPDMLTAVGNVILANDTAALVHPEMTDSSIEVISRVLGVDVHRGTIAGLGTVGMAGVVTNRGLLVHPMVTPDELSVLEDVFALPIELGTTNYGSQAVGSGLLANSKGYVAGSNTTGHELGRVEDALFFA
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: BGAL_ALIAD
Sequence: MAKHAPIFPNVQGFLHGGDYNPDQWLAYPDVLEQDVQLMREAKWNVVSLGIFSWVSLEPEEGLFTFEWLDEAIERLTHAGVRILLATPSGARPAWLSAKYPEVLRVGPDGRRNRHGGRHNHCYTSPIYREKVRIINRKLAERYAHHPGVIGWHVSNEYGGECHCPLCQEAFREWLKRKYKTLDALNHAWWTPFWSHTYTDWSQIESPMPHGETSIHGLNLDWKRFVTDQTVDFCRHEIEPLKQVNPNLPVTTNFMGTYPGLNYWRFRDVLDVISWDSYPRWHAHETLVPEAVHTAMVHDLNRSILKKPFLLMESTPSVTNWQAVSKQKRPGVHVLVSLQAVAHGADSVQYFQWRKSRGSYEKFHGAVVDHVGHANTRVFRDVQAVGEMLERLAPMAGAEVKADAAVIFDWENRWALEDAKGPRNIGMHYEETVVNHYAALWRMGVPMDVIDEEQPLDGYKLVVAPMLYMVRPGVAERMKAFVERGGSLVLTYWSGIVDENDLVFLGGFPGPLRELAGVWAEEIDALYDGERVPVRVADGNPLGLAGHYEARELCEVVHLEGAEPIAVYGADYYEGMPAATVHRVGKGKVYYVAARLEDAFLRDFFARVAAEAGVARAIERELPDGVSAMVRSGDGVEYVMLMNFTPEAREVALDEAEYKPLYGEAPTDGAVRLPAYGVSVLERPARNG
What is the function of this protein?
Hydrolyzes o-nitrophenyl-beta-D-galactopyranoside (ONPG) and p-nitrophenyl-beta-D-fucopyranoside (PNPF), but not p-nitrophenyl-beta-D-glucopyranoside (PNPG), p-nitrophenyl-beta-D-xylopyranoside (PNPX) or p-nitrophenyl-beta-D-arabinopyranoside (PNPA).  Also hydrolyzes lactose, including lactose in milk.
What are the official names of this protein?
Beta-galactosidase BglY, Beta-gal.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 42 family.
Protein: YCVC_SCHPO
Sequence: MKINLFFVFLFELLHFVAAYSCEGDESAAIEAMNVLQVPYEKYNTDPVCAFDNSTVVELSDKTWDHVIESGKWFVQLTAEGCANCTLGELLFNDLSHAFHEKYPDVHFARVYLSSSLELSVRLLISRIPSYYFIDNQNFYRVSPQVLPKNKAIALYEKDGFKSMKKEQGFFSVNGPLKSFYWVFGKALALYGHLSQKYTPLGMNVAIFGISAYIMYRSSKKAKQKQAAAAAAAAAKKK
What are the official names of this protein?
Uncharacterized protein C777.12c.
Protein: RUTA_ENTCC
Sequence: MKIGVFVPIGNNGWLISTTAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMASTIDSISGGRFGVNLVTGWQKPEYDQMGLWPGDEYFSRRYEYLTEYVQVLRDLWGTGKSDFKGDYFTMNDCRVSPQPSAPMKVICAGQSDAGMAFSAKYADFNFCFGKGVNTPAAFAPTAARMKEAADKTGRDVGSYVLFMVIADETDEAARAKWERYKDGADDEALSWLTEQSQKDTRSGADTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAAVPGAEGVLLTFDDFLTGVETFGERIQPLMQCRAHIPAITKEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: QUEC_STAAB
Sequence: MESVLNNEKAIVVFSGGQDSTTCLFYAKKHFKEVELVTFNYGQRHDTEIEVAKQIAQDQGMKHHVLDMSLLSQLTPNALTQHDMEITNNEDGIPNTFVPARNLLFLSFAGALAYQIGAKHIITGVCETDFSGYPDCRDSFIKSMNVTLSLAMDKDCVIHTPLMWLNKAETWKLSDELEVLDYIRTKTLTCYNGIIGDGCGECPACHLRQRGLNQYLESKGAL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: ATP6_TOLAT
Sequence: MASTGETLTSQEYIAHHLHHLQVGSGFWTVNIDSMVFSVVLGTLFIWLFRRVAVKATSGVPGKLQCFVEIVFGFVDDTVKGIFHGKNKLIAPLALTIFVWIFLMNAMDLLPIDYLPHLAQISNIPYLRVVPSADVNITLSMALGVFFLILFYSIKIKGIGGFVKELTMTPFNHWAFVPINLLLETVTLISKPISLGLRLFGNMYAGEMIFILIAAMLPWWSQWFLNVPWAIFHILIITLQAFIFMVLTIVYLSMACEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 013L_IIV3
Sequence: MYYRDQYGNVKYAPEGMGPHHAASSSHHSAQHHHMTKENFSMDDVHSWFEKYKMWFLYALILALIFGVFMWWSKYNHDKKRSLNTASIFY
What are the official names of this protein?
Uncharacterized protein IIV3-013L.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RLMH_ECODH
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAMPT_MOUSE
Sequence: MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIEQDVAPH
What is the function of this protein?
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity).  Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD.  It is the rate limiting component in the mammalian NAD biosynthesis pathway.  Plays a role in the modulation of circadian clock function.  NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
What are the official names of this protein?
Nicotinamide phosphoribosyltransferase, NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1 homolog, PBEF, Visfatin.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100- fold higher concentrations compared to maternal serum.
Protein: QUEF_SALCH
Sequence: MSSYENHQALDGLTLGKSTDYRDNYDASLLQGVPRSLNRDPLGLTADNLPFHGADIWTLYELSWLNSQGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFDTWETVRQTLERDLRACAQGNVSVRLHRLDELEGQPVAHFHGTCIDDQDISIDNYQFTTDYLQHAVSGEKQVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRKIDREKLLRYLVSFRHHNEFHEQCVERIFNDILRFCQPETLSVYARYTRRGGLDINPWRSNTDFVPATGRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_MYCSS
Sequence: MIDLKFLRENPDAVRASQRSRGEDPALVDALLDADAARRAAVSAADNLRAEQKAASKKVGKASPEERPALLTQAKELAEQVKAAEAAQADADRTFTAAHMAISNVVIEGVPAGGEDCFAVLDVVGEPRAIDDPKDHLELGEALGLIDMERGAKVAGSRFYFLTGRGALLQLGLMQLAVRLATDNGFTLVIPPVLVRPEVMAGTGFLGAHADEVYRLESDDMYLVGTSEVPLAGYHADEIIDLSAGPRRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEGFIYCKPEDAAAEHDRLLGWQREMLALIEVPYRVIDVAAGDLGSSAARKYDCEAWVPTQQTYRELTSTSNCTTFQARRLSTRYRDENGKPQIAATLNGTLATTRWLVAILENHQQPDGSVRVPAALVPFVGTEVLEP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.