Protein: SETVS_PLAF7
Sequence: MEYKLFKNKKILNEKVNELTKKNRQRNTLDHINCIEIDDDDDDDNDNNEEPKEMNINKTNNNNNDILMKSCNDIRRNTTFYRHNVINEEQKNFEYLLSRKKKNVDSIDNVNFYDFMKNDFFNIFNNNIISEHKKTNQIVNQINNNVDTSKNVVYNINYDEHKGEVVNLSFDKKGKETYPQVDIELYNKKMNPRYQNINEQNTCQTSDDNTTYRNVYSDNCALNSSYTNFLRNKSLKYKKCYKQNRQDESTGAEFDYNLDESVYYDDCNNKLYKRSFLKNNKNIIEKGREEHKQDIYNNISDICKSYIKNFDYLNKRIFHNKSKIWKLSNKKVTIHGDPKKRIERNKQEIEDHRREQDGENDQEEDNYDDYDDEDDDDDNCHIYDNYDDYLENDDYDNHNYFYHKNHDVNKIRKIQNKNCSTDFINYTSINNRNMECPNKNADNLKNMDSFLLYMKERKIKKKKNINDHMENQLSDTLNNSNNYNKDVYDSYYDDMNFCYDKDYNMILKKGVNSNRTKSLDRYPNNISHNYVNNISSEIIKYCKDNNITLKSDIKNIINHFNKKYANSSLTNSKISMYENGYPQRSVDRIYDSSTNDPKSDMNGSNNNNSSSNNNNNITHITNDCDNTQTNKNKHYVNSIVNSIVNIFQKRKNVNEKKENINEQNCISFNTNLRNNKLNNNDDLCSNSYVNNINRNKQITNNENKKDNMLMLKGTYHGDSLNESINIEHNLKNNNSMSDVNFVLNNNDNDKKQNSYDISEVSINCYYDDVIKCYMDYTMHGMEDETNFYLCEFCEQNIFDMNNMIKKDKAKECMYRCNISCGRTFHKACVCYIKNNDNYICFFCLYDINFCTLCKEVLTNDSLLPCYYPLCSVSMHTKCVEKLLLFNSHCLKQYESIILPRDINIEQQKNTQKSASDGIIEQPLNIKKKIKRRHIYRKRRRRGPRKSQITTSNKKINKSELAGGSIINGVDMEQENDQGGNNNNNDDNNDDNNDNNDDNNDNNDDNNDNNDNNDDNNNDNNNNNNNDNNDNNNNNNNNNNNNDNDNNNNNNCDENFKNHLLKKDLLRDEPHHNNYDKILECNTEIKMENNVNMSEEPIYNKLFNGKEETLNNENDEKIIVLKKFICPLHICYVCKEFDINNTESSKKELKNNLFRCIKCYKSVHRKCMNQLKNNDNNDNDNNNNNINIYIISHKHRIICCANHMDDYKKEHMEYLKYIKEVKDICKLDEPIHNNNNNNNILSEKGFYGDENNLSISKFHNNSSYEPIKNKETCIKGKDSNYLSHDNKGITDMNNTNKMNVLNLKSCMVNDMNTSERKKKKSCESRGSNITNKKVVFDLTDELNEKEKSPPLDNVQNKIIYGDNEIEKNVNICQKEDGGLNLGSMNILSIGKNHMRTNNNNNNDSSCSSNNNIISVENEYILKNKNLNKSNNSLLDHNNKIKKNSTLNIKECTDSCINVDEFINKNQNEKDISLENIDALCIKRKRNVSHPYNDTLDDTNILKDISNNKSYYVNISKKKRNVSFNYKEEFMKGDEQFLLKGNNLESNEKNTKNKLCNNDNNNNNNNKGKNTKYNTLDRKNNKNKQINDTINKEPENINHNMQNQQLTDNFVEDNMKYKQEIYHIKLSHILSIEKGLLSLQEINIDQMNDECKKHISILCTFRQDFINYVIFLFSKRLHKENQIEPVNGVDHKKEGNIYHAERKQEKINHNAKHNEQGSINNAKHNEQGSINNAKHNEQDSINNAKQNEQDSINNAKHNEQDSINNAKHNEQDSINNAKHNEDDSLNNAKHNEDDSLNNAKQNEEDSLNNAKQNEEDILNNDDHRNQEELHERWKENMVYNFLANYDKKEKKYISKKEEDAIIKILSNDIVGIMKKELKISLYDFIMLKKKTISTNENHKDNDESVVYVEDGKHHCNDINKMKDNVNNDIIPNIKYNNNNYDDVINTKEKESIPDASYMKVTRNQSIMNNDIYNNNIQIIEKERIMNNNKKNYYDEEKKREEYNGLFSKGKKKSFKNNKMDLKTFFSLTNNGYKVDISILKKYSSFLKFEYISKNIYLNDKNKNLLACKSDDYKCLCQGECNLYTCYNSLSNIQCSKSRCNLPEKIQDRKCFNRPFRKSFVKDLEIKKTEKTGYGVFCKRDIKNGELICEYVGEVLGKREFEKRLEVYQEESKKTDMYNWYIIQINKDVYIDSGKKGSISRFINHSCSPNSVSQKWIVRGFYRIGIFALRDIPSGEEITYNYSYNFLFNNFECLCKSPNCMNYHLLKKGESSGASNIIKETELLNNTIFNPVENFHNLHGKMQDWNIFIEEAHTRLLYEYNKMNAFNLRLMECYSTWIFYDMNFQKNQFFSLKSKPYNVSAEFWKVLVSAFSDGEKNIINTFNLFLPSLIKIGQLRRIQQYSYILHNIIGLEHDMWNLIDKGFADDEVCRKCKSCGNLTMCDKCFQSYHQLCGNMHSKMYKNNELVLCRFCQKYDYKIQWIKENHGSKMKTCIEIRSKAFYKLNRDIMTLLEESVKYTQNQSLDSIHAHNTKAFKSKKLKLRKFQYKYVKI
What is the function of this protein?
Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes.  SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein.  During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced.  The parasite then switches to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response.  Represses expression of both var mRNA and antisense long non-coding RNA.
What are the official names of this protein?
Variant-silencing SET domain-containing protein, PfSETvs, SET domain-containing protein 2, PfSET2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes along the entire gene body of silent var genes, including the transcription start site of var genes and the respective intronic antisense promoter.