PharMolix/UniProtQA huggingface dataset:
Protein: SYT11_MOUSE
Sequence: MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPRRESGRGNLLINAESGLLSHDKDPRGPSPASCMDQLPIKRDYGEELRSPMTSLTPGESKATSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPVFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPIAKWHSLSEY
What is the function of this protein?
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable).  Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685).  Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685).  Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661).  In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:28686317, PubMed:23303671).  In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452).  Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822).
What are the official names of this protein?
Synaptotagmin-11, Synaptotagmin XI, SytXI.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass membrane protein. Perikaryon. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Postsynaptic density. Recycling endosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass membrane protein. Perikaryon. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions (PubMed:30808661). In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (PubMed:28686317, PubMed:23303671).
Protein: RSMC_ALCBS
Sequence: MENTTQLLLRQSDALAGRNVLVVDANDPALKTLSVDATVHVHADDYTIGAQQWAPAPTVPAGTDLLVLPLSKSLDRLRFLLNWLAGEIAEPTELWLIGPTKGGIRGALKYLEAHVDGTMLEDSARHCKLYSGLLQPGEKQSLNAWGTVLEVADQEAVSYPGVFSHGRLDEGSALLLQAMEGHNLGKPGKVIDMGCGAGVISVWLARHGWQVQGVDVSASAVTASTESLARNGLQGRIMGGDLFSPIQGRVDMVVTNPPFHDRRQRTTDITRRLIAEAPTYLKPGGVLWLVANRELPYVQWLDDAFSHVQVASETTRFRVYRAVLS
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_BRUSU
Sequence: MYNYLDFEKPVADLEGQILELKKLAQEQGSVEMGDEISRLEKRSADALKDIYRKLTPWQKAQIARHPDRPHCLEYIDRLFTEFTPLAGDRKFANDEALQAGFGRFNGTPVAIIGQEKGSDTKTRLKHNFGSARPEGYRKAVRIMEMADRFQLPLITFVDTAGAYPGVSAEERGQAEAIARSTAECLKLRVPVISIIIGEGGSGGAIAIAVANRVYMLEHSIYSVISPEGAASILWHDSTRAKDAASNMRITAQDLFDLKIIDGIIPEPLGGAHRGKESVIDATGDIIAASLRSMKDIDGETLKQERRQKFLEIGRNI
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_BURCM
Sequence: MTAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEHGGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRAALKPILDAFERASQNGN
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSPA_CERCE
Sequence: VIGGAECNINEHRSLVLLYYSSRLFGGGTLINKEWVLSAAHCDGENMKIIYXXXXXXXXXXKDRQIRVAKKYFCRDRKKSVIDKDIMLIKKPVNGSTH
What is the function of this protein?
Thrombin-like snake venom serine protease that preferentially cleaves the alpha-chain of fibrinogen (FGA).  Induce platelet aggregation in the presence of exogenous fibrinogen.  Possesses esterase and amidolytic activities.
What are the official names of this protein?
Thrombin-like enzyme cerastotin, SVTLE, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HEPD_ASPOR
Sequence: MNSISALFSAGGFQWILLSLSLAFIVVYSLFYLAVGLYNLYFHPLARYPGPLLGRASSLWYARSLARGTVAQDTLKLHEKYGDVVRIAPDELSFIQPENWSAIYGHQLGKDYRELIKDPRYHDTVKPTPTILTGDWDEHTFYRKILSNSFSEKSLKDQEHILHHFVDLFVQRLKETSAEGTRELNMTDQWNYLTFDVIGFLTYGEEFHCLTSSKLHDWIEAMLCVAILMSLGQAARHLPFPFDKIYKQWAIPSNVKRQVALHRDLTEVAIPHIPIQYASAYRLNSRKGDIPYSVLKEHANILTIGGSETTATLLAGATFHLGKNPPVLQKLATEIRTTFVNDGEITVARLSECKYLLATVEECLRIYPPSPANHTRMVPKEGIVLNDQHIPGGIGVGMPMYAAFRASSNFTYPDRFAPERWLGDPMYSKDKKGALQPFSFGPRNCLGRHLAYQEIKLALAKLVYHFDLELNPKCGDWDEQKNFTFWVKPPLWVNLHPVKS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of heptelidic acid (HA), a sesquiterpene lactone that acts as an inhibitor of glyceraldehyde-3-phosphatedehydrogenase (GAPDH) and a growth inhibitor of the salt-tolerant lactic acid bacteria in soy sauce brewing.
What are the official names of this protein?
Cytochrome P450 monooxygenase hepD, Heptelidic acid biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PG155_VACCA
Sequence: MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGGTPALDRRVQDVNDTISDVKQKWRCVVYPGNGFVSASIFGFQAEVGPNNTRSIRKFNTMQQCIDFTFSDVININIYNPCVVPNINNAECQFLKSVL
What is the function of this protein?
Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).
What are the official names of this protein?
Envelope protein OPG155.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG155 protein family.
Protein: UPP_CORDI
Sequence: MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVADTQGTRLQDPPIIVPIIRAGLGMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDLSGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVSAQEGVDALAESGLPCRLVTATIDPELNDDAYIVPGLGDAGDRLYGPRNIDL
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MUTS_DESOH
Sequence: MASTGATPMMQQYLSIKEQHRDAILFYRMGDFYEMFFEDAQTAAPVLEIALTSRNKNDTDPIPMCGVPVKAADGYIGRLIENGFKVAVCEQTEDPAAAKGLVRRDVVRIVTPGMIIDNALLEKGTNNYVVCLAHADGVVGFASVDISTGTFRVCESSDLRAVRHELLRIAPREVVIPESGADDAALSPFVSLFPPAIRTTLANREFDYRTACQRLTDQFQTRSLEGFGCRGLKPGIVAAGALLSYVNDTQRQKASHLTGLEVYSIDQYLLMDEVTCRNLELVANLRNNGRQGTLIDVLDACVTAMGSRLLRRWMLYPLLSAEAINRRLDAVAEAKEGLGTRKAVRELLKQVYDIERLTSRAVMGRVTPRDLLALKQTLFALPGLATELKSFDSPFFSFAGEPGPEGLDKLAGLADLLKAAVREDAPVSIADGGVINPDYHPRLAELVTISRDGKSSLARLEATEKEKTGISTLKVRYNKVFGYYIEVPRSQVGAVPAHYVRKQTLVNGERYITDELKVFEEKALGAEEQRVRLEQELFADIVGRVTACSPMLFAVARVAAGIDVLCALAQVADDHDYVRPEMLSGGEIIIEEGRHPVVERMLSGERYVPNSITLNDTDRQLLIITGPNMAGKSTVLRKVALFSVMAQMGSFVPARRAAMGVVDRLFTRVGALDNLASGQSTFMVEMEETANIINNATPKSLVVIDEIGRGTSTYDGLSIAWAVAEALHDLHGRGVKTLFATHYHELTELENTRPRVKNFHIAVKEWNDTIIFLRKLVEGSTNRSYGIQVARLAGIPGPVIARAKKILLDIEQGTYSFEAKSGTAPGTGQSGPVQLSLFTPPEQMLVDRLQKVDISTMTPLEALNCLHELQQKAHAISETDG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RGS10_MOUSE
Sequence: MFTRAVSRLSRKRPPSDIHDGDGSSSSGHQSLKSTAKWASSLENLLEDPEGVQRFREFLKKEFSEENVLFWLACEDFKKTEDRKQMQEKAKEIYMTFLSNKASSQVNVEGQSRLTEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKPKRTEEEEEEPPDAQTAAKRASRIYNT
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2.  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.  Modulates the activity of potassium channels that are activated in response to CHRM2 signaling.  Activity on GNAZ is inhibited by palmitoylation of the G-protein.
What are the official names of this protein?
Regulator of G-protein signaling 10, RGS10.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus.
Protein: Y310_STRP4
Sequence: MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHAARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKFNELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMGKNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPVWNLPLHHPVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYASPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMNDLGITPADRKVAVVARQKAEETGGPALALELPNGDIVTGKNSELFGPTAAALINAIKKSADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEELGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK
What are the official names of this protein?
UPF0371 protein SPG_0310.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: PS_PIPNI
Sequence: MAPSSQLEFNVVRKQPELLPPAEPTPFEWKELSDIDDQDGLRLHISGFFIYPPSTMSNVGRDNVARDIRLGLSKAMVFYYPLAGRIREGPNRKLSVECTGEGIMYCEADADVRLEQFGDIGALSMPFPFMDKVMFETVDDGILGTPLMYFQSTRFICGGIVIAGCYNHAIADGLGFYMFMAAAAQLARGAASPTPLPVWQRERLLSRVPPRVTFIHHEYIHDTPKTETANPLDNEPWPLHSIFFTRVDVAALRAQLPGHLRKSATSFEIISACLWRCRTAALRFAPDELSRLIIAVNARTKFGPPLPQGYYGNSIMLPMVVSEAGKLVLSGLGYAVELVIEAKGKVTEEYVKSVADYLVLNGRPHYVVTNTYLVSDLRQLVEMSKFDWGWGKPAYVGPADVGENAISFLATLKNGEEEGVVVPIRLPESAVGRFKSEVSKMVSFGCLEDVKPNRDGYLSRM
What is the function of this protein?
Involved in the biosynthesis of aromatic piperamides natural products such as piperine (1-piperoyl-piperidine), the pungent principle contributing, together with several terpenoids, to the aromatic properties of black pepper fruits, and displaying numerous pharmacological activities such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, antiobesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects (PubMed:33833371).  Mediates mainly the conversion of piperidine and piperoyl-CoA to piperine (PubMed:33833371).  Can also use pyrrolidine and isobutylamine as acceptors and 3,4-methylenedioxycinnamoyl-CoA as an alternative CoA-donor with a lower efficiency (PubMed:33833371).
What are the official names of this protein?
Piperine synthase, Piperidine N-piperoyltransferase, Piperoyl-CoA:piperidine piperoyl transferase, BAHD-type acyl transferase 2, PipBAHD2.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: COBS_ECO81
Sequence: MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGAPLAALFSVLVLVLMTGGFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGESILASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIELGELVFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSHR_SAGOE
Sequence: MPMQGAQRKLLGSLNSTPTATSNLGLAANHTGAPCLEVSIPDGLFLSLGLVSLVENVLVVAAVAKNRNLHSSMYCFICCLALSDLLVSGSNMLETAVILLLETGALATRTSVVQQLHNTINVLTCSSMLCSLCFLGAIAVDRYISIFYALRYHSIMTLPRAQRAIAAIWVASVLSSTLFITYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAHGIIRLHKRQTPAHQGFGLRGAATLTILLGIFFLCWGPFFLHLTLVVFCPQHLTCSCIFKNFKVFLTLIICNTIIDPLIYAFRSQELRRTLKEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR5_BACC7
Sequence: MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGENIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYEVYGMAHITGGGFIENIPRMLPEEIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDVVRLLEEQGETARIIGRTVQGAGVTFNGGTAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_PHOLL
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYAKKLGVDIDNLLCSQPDTGEQALEICDALTRSGAVDVIIVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKSSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGSVKNGEEVVGSETRVKVVKNKVAAPFKQAEFQIMYGEGINTYGELIDLGVKHKLVEKAGAWYSYNGDKIGQGKANATIYLKEHPEVATELDKKLREMLLHNAGEFNSAASDYEDNENEEMNNEEF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1C_CABCA
Sequence: MKEQKLIHEGLITESLPNGMFWVRLDNEDLVLGYVSGRIRRSFIRILPGDRVKIEVSRYDSTRGRIIYRLRNKDSND
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYL_RHIME
Sequence: MATERYNPRDAEPRWQHQWEAGKVFETKNDDPRDKYYVLEMFPYPSGRIHMGHVRNYTMGDVVARYKRARGFNVLHPMGWDAFGMPAENAAMERGVHPASWTYQNIASMKAQLKVMGLSLDWSREFATCDPEYYQRQQHLFLDFLEKGLVYRKQSKVNWDPVDNTVLANEQVIEGRGWRSGALVEQRELTQWFFRITDFSQDLLDALDTLDEWPEKVRLMQKNWIGRSEGLSVRWELDPATVPGEEKEVTVYTTRPDTLFGASFLAISADHPLARDAAAKNAEIEAFCEECRRAGTSLAALETAEKKGIDTGIRARHPFDPNWELPVYVANFVLMDYGTGAIFGCPSGDQRDLDFARKYDLPVVPVVMPKDADPQTFTIGDEAYDGDGVMINSRFLDGLSAEEAFETVASRLENDLLNGTPRAERKVNFRLRDWGISRQRYWGCPIPVIHCDDCGVVPVPKADLPVTLPPDVTFDKPGNPLDRHPTWRHVACPQCGKDARRETDTMDTFVDSSWYFTRFTAPWEDNPTDPKAANHWLPVDQYIGGIEHAILHLLYSRFFTRAMKATGHVALDEPFKGLFTQGMVVHETYSRGEGAQREWITPAEIRVEEVDGQRRAVHIETGEEVAIGSIEKMSKSKKNVVDPDDIIGSYGADTARFFVLSDSPPDRDVIWSEAGVEGAHRFVQRVWRLLTEAAERLRAVDAAPASGGEGLAVSQAAHRTLKAVEADYDKLAFNKAVARIYELVNAMAAPLTQVASGKADNALTAAVKDAAAILINLIAPMMPHLAEECWREIGGKGLIAERPWPKFDPALIVENEITLPVQINGKKRADLTIARDADQSAIESAVLALDAVKAALNGGRPKKIIVVPQRIVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY2_VIBCH
Sequence: MASIEAALAEIKRGVEELIPEEELIAKLKENRPLRIKLGADPTAPDIHLGHTVILNKLRTFQDLGHDVTFLIGDFTGMVGDPTGKNTTRPPLTREDVLRNAETYKQQVFKILDPAKTKIQFNSEWLSKLGAEGMIRLASNQTVARMLERDDFKKRYNNGQPIAIHEFMYPLLQGYDSVAMETDVELGGTDQKFNLLMGRELQKANGQKPQVVLMMPLLVGLDGEKKMSKSAHNYIGVSEAPSEMFGKIMSISDDLMWSYYELLSFRPLEEVAQFKAEVANGANPRDIKILLAKEIIARFHSQADADAAEQEFINRFQKGAMPEEMPEFEFESGIAISNLLKEAGLVASTSDALRMIKQGAVKLDGEKLEDAKLIPACGTSVYQVGKRKFARVTIK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 2, Tyrosyl-tRNA synthetase 2, TyrRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA_INCJH
Sequence: MSKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDEYLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQFVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKLRIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVPLPFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRLPKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPKDKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKIPEISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVPMAEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRLFPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDGMYTIITFEFSIREPNLEKHQKYTVFEAGHTTVRMKKGESVIGREVPLYLYCRTTALSKIKNDWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGELIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKSSFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFKTD
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: PYRD_AGRFC
Sequence: MSGLFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTVAGLVFPNPLGMAAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGHAAALERLTQARLRGIVGVNIGANKDSEDRIADYVQGIEAFYAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLDGLIVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSSAETALEKVRAGADLVQLYSCMVYEGPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRKLG
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: EFPL_SHIBS
Sequence: MPRANEIKKGMVLNYNGKLLLAKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLTRRYVDFSYVDGNEYVFMDKEDYTPYTFTKDQIEEELLFMPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSPGEKIRIHIEERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: COMQ_BACNB
Sequence: MSHLVKWNGRGEVVIEQICLDSVRIKEKMKEIVDENILNEDLKVKLISFIKEKKQFSFAELAYYHYIAFDGKNDKAIELLASGIELLILSADIFDDIEDKDNLQASWMKLDPSIATNAATALYTLSLQVIGSVSNHPKLLSLTLQYSLQSLQGQHVDLNLTASSESEYIEMIKLKSGSLVTLPSILGVYLATGEYNETVEEYSRYLGIVEQIANDHYGLYYPNYNDFKTRHTLAFNYLKNKFNQSSIDLLNFYAQENHMINNLEDLKGKLRESGVIQYLNVIKNLAVENFKESFKKLRLDEQRKNKLLIQLLRGI
What is the function of this protein?
Part of a major quorum-sensing system that regulates the development of genetic competence (PubMed:25855042, PubMed:29665236).  Involved in the maturation of the competence pheromone ComX (PubMed:25855042, PubMed:29665236).  Acts by catalyzing the transfer of a farnesyl group on the ComX pheromone (PubMed:25855042, PubMed:29665236).  In vitro, can also catalyze the farnesylation of single tryptophan and tryptophan derivatives (PubMed:29665236).
What are the official names of this protein?
Tryptophan prenyltransferase ComQ, ComX-tryptophan prenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: DAPF_AQUAE
Sequence: MEFWKLQGSGNDFVVIDDRDEKLESFLKERGVSKEDFVRKVCAFHTGVGADGLILIKNPDNPENDFKWEFFNSDGSVAEMCGNGSRCAVRFAYERGIVGNKVRFETLAGVIKAEVYENGRKVKVQLTPPSKPEEKTLTVDGEEVIGVFINTGVPHFVVPVEDVEKVNVIKLGRAIRFHEEFQPKGTNVNFVQPVSEDTIKVRTYERGVESETLACGTGATACAIVSYLKGLVKKKPVNVLTRSGEVLTIDFSEDLKEVFLTGSVYKVFEGRLSEEVLEY
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.