PharMolix/UniProtQA huggingface dataset:
Protein: HSP1_MYOME
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHRNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: COBS_SALTI
Sequence: MSKLFWAMLAFISRLPVPSRWSQGLDFEQYSRGIVMFPFIGLILGGISGLIFILLQPWCGIPLAALFCILALALLTGGFHLDGLADTCDGIFSARRRERMLEIMRDSRLGTHGGLALIFVLLAKILVVSELALRGTPMLAALAAACAAGRGSAVLLMYRHRYAREEGLGNVFIGKVSGRQTCITLGLAVIVATVLLLGMQGLATMVVTLAAIFILGQLLKRTLGGQTGDTLGAAIELGELIFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HEM1_PSECP
Sequence: MVLFSLVATHADIDLETVAQLSNGSSGIAASVLSGSPAVSGAVVLATCNRYEIYGEAPNTDDVEAARAALVAQISAQSGLAEPLVSRSFSTRTGPEVTRHLFAVSAGLDSAVVGEREIAGQVRRALITAQHEGTASSGLVRLFQAASKTAKDVGAQTALGSRGLSIVSVALDLATDLSENPDWSAKKVVVFGTGAYAGATMALLRERGCTDVSVFSSSGRAEGFVATRGGTALDADSLRPAVAAADVMIGCSGSDTRVEADELAQVRAGSAQPLIAIDLALTHDFDPAVGELNGVELLTLESVRLAAPQEQAESLAQASGIVKGAAKAFEQEREARSVDSAIVALRRHTMDVLDAEMEKVRARHGCTAAAEEVEFALRRMVKQLLHVPTVRARELAANGQQDDYVAALEALYGITVEQPGTAAPAAGQAECPVDHKGLESA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: SYC_METM7
Sequence: MLKVYNTLTRKEEEFKPLNENEVKMYVCGPTVYDHTHLGHGRTYVSFDIIRRYLEHIGYTVNLVINFTDIDDKIIKRSQEKGKNPKELSETFVNVFLNDMATLKVKPADIYPKVTEHIPEIIAFIEKLIEKGFAYKTENGVYFEVKKFENYGKLSNINLEDLISGARIEPSDEKKNPEDFALWKTAKPGEPKWESPFGEGRPGWHIECSAMSSKYLGEQFDIHGGGRDLSFPHHENEIAQSVAYSGKDWVNYWLHTGFVMVNGEKMSKSLGNFITIEDISKEYDPEILRFFFIQRHYRSPIDYTAESMSHVKNNLEKIYNVIENIRISLEKSEKSGIWNENEFLLYDILKNSKHNFYEAMNSDFNTVEALKSVFEVSNGVNKYLSLVKTPSEGLLLKAFDFFKIVGEIFGLFENYFKESSESNDEGFVKFLIELRSDLRLQKNYEMSDKIRDGLKELGYQIEDNPKEGTVFKKINI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABAH2_ORYSI
Sequence: MAFLLFFVFVTAAVLCFVVPAFLLLCTSVQRRRDVGQGGGRDWQKKKKLRLPPGSMGWPYVGETLQLYSQDPNVFFASKQKRYGEIFKTNLLGCPCVMLASPEAARFVLVSQARLFKPTYPPSKERMIGPSALFFHQGEYHLRLRRLVQAALAPDSLRALVPDVDAAVAATLAAWSGGHVASTFHAMKKLSFDVGVVTIFGGRLGRRHREELRTNYSVVERGYNCFPNRFPGTLYHKAIQARKRLRAILSEIVAERRARGGGGDDLLGGLMRSRDDGTAGAVALLTDDQIADNVVGVLFAAQDTTASVLTWILKYLHDSPKLLEAVKAEQMAIYVANEGGKRPLTWTQTRSMTLTHQVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHNPDYFQDPQKFDPSRFKVAPRPSTFLPFGSGVHACPGNELAKLEMLVLVHRLVTAYRWEIVGASDEVEYSPFPVPRGGLNAKLWKQEAEEDMYMAMGTITAAGA
What is the function of this protein?
Involved in the oxidative degradation of abscisic acid.
What are the official names of this protein?
Abscisic acid 8'-hydroxylase 2, ABA 8'-hydroxylase 2, Cytochrome P450 707A6, OsABA8ox2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLSA_RHOPB
Sequence: MTELDVVVQEIAEEIAARSDRGSVAHYIPELAKVDPAGFGLVVIDADGHVAAGGDADTAFSIQSISKVFTLTLALGKIGDRLWQRVGREPSGSPFNSIVQLEFERGIPRNPFINAGAIAVTDVILSGHQPREALGEILRFMRFLTGDPTIAIDQAVAASEQRTGFRNAALANYMKSFGVLDNPVDYTLGVYFHHCAIAMSCRQLALAGRYLAHSGRNPSTGHSVVSPGRARRINAVMLTCGHYDGSGEFAYRVGLPGKSGVGGGVLAIAPGKASIAAWSPGLDASGNSHLGRVALEALSKRMGWSIFGV
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: LFTR_POLSJ
Sequence: MGKLPRPVPWLAAGENFPPLEFAWGRHDPAPGLLAAGAALDVPTLIQAYSRGIFPWFSLGQPVLWWSPDPRMVLHTEKFKLHRSLRKSLIHFLDDPECEIKFDSAFEHVIKACASQPRAGQPGTWIVPDMVQAYSSLHRAGYAHSVETWVRGKLVGGLYCVKLGRMVFGESMFAHQTDASKIALAALVGFCRAHQIAMIDCQQNTRHLASLGAAEIDRADFVRHLAQNVEKTTPPWQFEPVYWKQILTAEKPTLP
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRH4_NEOFI
Sequence: MNRLGRLPLPLPPSVCLFCQSRATTPLPPSLQATRSMATARLRRRVARMTLSPDVAKPSVVKKTRGDKERFGPFAGMNQTEARIRDKPRTRSRAAQKRSGEPEEDSQKESPLYKALKMQTALAPIPYGRRAAIKAKIADITSFDQFQLLPVVRNSISSQALPGLVDVTPTPIQRLAIPRLLEEPKTEKKPTKADDDEPQYDQYLLAAETGSGKTLAYLLPVVDAVKREEARDKELEKKEQEEKAREREEKLKNRAFDIEPEIPPLSNAGRPRAIILVPTSELVAQVGVKVKALSHTVKYRSGMISSNLTPRRIKNTLFHPDGIDILVATPHLLASIAKTEPYVLSRVSHLVLDEADSLLDRSFAPTTTEIISKAAPSLRKLILCSATIPRSLDNLLRKRYPDIKRLTTPNLHAIPRRVQLGVVDIEKDPYRGNRSLACADVIWSIGKAGDAESEGPYASYVAPKTKKILVFVNEREEADEVAQFLRSKGIDAQSLSRDSDARKQEEILAEFTEAPPPPTPDEILLAQKQRRHEDAIPFEMPQKTNQDSSRRLANTKVLVTTDLASRGIDTLAVKTVILYHVPHTTIDFIHRLGRLGRMGKRGRGVVLVGKKDRKDVVKEVREGMFRGQALI
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase mrh4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YD169_YEAST
Sequence: MMRMSLKQMQSQRFSATSRVRMLLIGASGLRSSSSKLECPRFSNKHGRN
What are the official names of this protein?
Uncharacterized protein YDR169C-A.
Protein: CB121_HORVU
Sequence: MASSSGLRSCSAVGVPSLLAPSSRSGRSGLPFCAYATTSGRVTMSAEWFPGQPRPAHLDGSSPGDFGFDPLGLATVPENFERFKESEIYHCRWAMLCVPGVLVPEALGLGNWVKAQEWAALPDGQATYLGNPVPWGNLPTILAIEFLAIAFAEQQRTMEKDPEKKKYPGGAFDPLGFSKDPAKFEELKLKEIKNGRLAMLAFVGFCVQQSAYPGTGPLENLATHLADPWHNNIGDIVIPRNIYGP
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein 1B-21, chloroplastic, LHCI type I CAB-1B-21, LHCI-730 chlorophyll a/b binding protein, Light-harvesting complex I 21 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ODPB1_ARATH
Sequence: MLGILRQRAIDGASTLRRTRFALVSARSYAAGAKEMTVRDALNSAIDEEMSADPKVFVMGEEVGQYQGAYKITKGLLEKYGPERVYDTPITEAGFTGIGVGAAYAGLKPVVEFMTFNFSMQAIDHIINSAAKSNYMSAGQINVPIVFRGPNGAAAGVGAQHSQCYAAWYASVPGLKVLAPYSAEDARGLLKAAIRDPDPVVFLENELLYGESFPISEEALDSSFCLPIGKAKIEREGKDVTIVTFSKMVGFALKAAEKLAEEGISAEVINLRSIRPLDRATINASVRKTSRLVTVEEGFPQHGVCAEICASVVEESFSYLDAPVERIAGADVPMPYAANLERLALPQIEDIVRASKRACYRSK
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial, PDHE1-B, Protein MACCI-BOU.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ATPG_STRMK
Sequence: MASGREIKTKIKSVQNTRKVTRALEMVSASKIRKAQDRMKTSRPYAQAMKQVIGHLAQASTDYQHPFLVEREQVKRVGFIVISSDRGLAGGLNNNLFRKMLGEAKAWQDKGAEVDLVTIGQKASTFFRRVKVNMVGSVTHIGDVPKLESLIGVIKVMLDAFTEGKIDRVYLVYNRFVNTMVQKASFDQLLPLPPAEKQVAHHDWDYLYEPDAATVLEHVMTRYIESLVYQALLENVASEHAARMVAMKAASDNANKLIGTLQLVYNKARQAAITQEISEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CDII_ECOLX
Sequence: MKKKLFALLKYIIFFPMLCTVLGLLGIPIGLIVNFLRTGSFDFNLKDEIDVVLFTLKIGIPIGFILGLGLWGLSILDRK
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Protects cells against CdiA from the same strain, its cognate toxin protein (PubMed:16109881, PubMed:23882017).  Growth inhibition is reversible upon induction of this protein, occurring about 2. 5 hours after induction, and requires an energy source (PubMed:19124575).  Does not protect against non-cognate CdiA from E. coli strain 563 / UPEC, D. dadantii strain 3937 or Y. pestis strain CO92 (PubMed:21085179).
What are the official names of this protein?
Immunity protein CdiI.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KDRDH_SPHSS
Sequence: MSVFAGRYAGRCAIVTGGASGLGKQVAARIIAEGGAVALWDLNGDALAATQAEIDATHVVALDVSDHAAVAAAAKDSAAALGKVDILICSAGITGATVPVWEFPVDSFQRVIDINLNGLFYCNREVVPFMLENGYGRIVNLASVAGKEGNPNASAYSASKAGVIGFTKSLGKELAGKGVIANALTPATFESPILDQLPQSQVDYMRSKIPMGRLGLVEESAAMVCFMASEECSFTTASTFDTSGGRTTF
What is the function of this protein?
Catalyzes the NAD(+)-dependent dehydrogenation of 2-dehydro-3-deoxy-L-rhamnonate to form 2,4-didehydro-3-deoxy-L-rhamnonate.  Does not show any detectable activity in the presence of NADP(+).
What are the official names of this protein?
2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+)), 2-keto-3-deoxy-L-rhamnonate dehydrogenase, KDRDH, L-KDR dehydrogenase, L-KDR 4-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: CTHL1_CHICK
Sequence: MLSCWVLLLALLGGACALPAPLGYSQALAQAVDSYNQRPEVQNAFRLLSADPEPGPNVQLSSLHNLNFTIMETRCQARSGAQLDSCEFKEDGLVKDCAAPVVLQGGRAVLDVTCVDSMADPVRVKRVWPLVIRTVIAGYNLYRAIKKK
What is the function of this protein?
Binds bacterial lipopolysaccharide (LPS).  Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro).  Has hemolytic activity (in vitro).  May play a role in the innate immune response.
What are the official names of this protein?
Cathelicidin-1, CATH-1, Fowlicidin-1.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRHK_PENBI
Sequence: MTISTTALGGGATTATRKQVEAKYEEERQIQLQSRGMVEDIEITRNASFEQFAKDPWAAPKQVDVEIQRERLLQQAHHKIIIIGAGFGGLLFAVRLIQTGKFKADDIILVDSAAGFGGTWYWNRYPGLMCDTESYIYMPLLEETGYMPRNKYASGNEIREHAERIAEKYALSERAIFRTVVQSLDWEEEGKVWKIAGVKLGKNDECQQPFQLIADFPIMASGAFASPRVPNYPNIFDYKGKLFHTARWDYKYTGGSIENPKMSGLADKRVAIIGTGATAIQIVPQLAKNSRELFVFQRTPAAVDVRNNYPTDPARFKSEIQGDGPGWQRRRQINFNAFTCNEKTLPTDNKIGDGWTRMPSFSVLIGGPQSLEPDYIDQIRPIDMARQSEIRSRVHKLVESTAIADSLTPWYPGWCKRPCFHDEYLQSFNSSNVQLVDIRHDGISRFTPNGLVANGVEYELDAIILSTGYTVPVTRASPSGRANITVTGRRGVTMEEKWANGLATLHGVMTRDLPNLFFAGTSQAGACVNLTYALDQNAIHVAHILSEAVKRQPSDCTKLVIQPTHEGEEAWTMEILQRAAGFRGIAGCTPGYLNGYGMDASSLKPEEQMNMARLAAWGEGIASYVDALEGWRSEGQLEGVEMTFFA
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
FAD-binding monooxygenase prhK, Paraherquonin biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: T2R30_PANPA
Sequence: MITFLPIIFSILIVVIFVVGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITVYNVWAVTNHFSSWLATSLSMFYLLKIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETIWTKEYEGNMTWKIKLKSAMYHSNMTLTILANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMIISVCNLGRLQKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVLWHVRYWVKDRSLRLHRFTRAALCKG
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 30, Taste receptor type 2 member 47, T2R47.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SRD63_CAEEL
Sequence: MDFFQYFFRYYWQLVYMICLMLYITMYILIYNFTGKTLQTVKYFLYPSCTAMLIAMTMAFATQTRNIDNTHSMALLCDGFCKYIGPTFCFYCYNLYTAFGIVVNLINLHTMYYRTLCLKYLDAKKVRLWTLVFMWHYLCPLIYLIVIITSPQRHLEVSMETLSLHPNFDYTPYLTFGGFSQAQKELLDKAAMSLSLISMYYPLIGTYWKHKAMKMLKSHMSPNTSDATRAMLQTLIKGLNFQILLPMLRYIPLTAIYFMIKYTGEQFLISQYTITVLGTIPCILDPLVQIYFIRDAIRKFLACNSSPVRRIYDSWASRMII
What are the official names of this protein?
Serpentine receptor class delta-63, Protein srd-63.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srd family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL23_LEGPC
Sequence: MNAERLMMVLREPHTSEKATVMADKFKQFTFKVLKNATKTEIKLAVEHIFNVKVKSVSVVNVKGKSKRFKQTSGKRSDWKKAFVSLHADQDIDFTVTE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MELB_KLEPN
Sequence: MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDIVGLSVGVVGTLFLVARILDAIADPIMGWIVNCTRSRWGKFKPWILIGTITNSVVLYMLFSAHHFSGGALLAWVWLTYLLWGFTYTIMDVPFWSLVPTITLDKREREQLVPYPRFFASLAGFVTAGVTLPFVNAVGGADRGFGFQMFTLVLIAFFVVSTLVTLRNVHEVYSSDSGVSEDSSHLSLRQMVALIYKNDQLACLLGMALAYNTAANIIAGFAIYYFTYVIGSAEMFPYYMSYAGAANLLTLILFPRLVKGLSRRILWAGASIMPVLGCGVLLLMALGGVYNIALISLAGVLLNIGTALFWVLQVIMVADTVDYGEYTMNIRCESIAYSVQTLVVKAGSAFAAWFIAIVLGIIGYVPNVVQSSHTLLGMQAIMIALPTLFFALTLFLYFRYYKLNGDMLRRIQIHLLDKYRRVPENDVEPERPIVVPNQV
What is the function of this protein?
Mediates the transport of melibiose and other galactosides by a symport mechanism.  Can use protons and lithium as coupling cations for cotransport, depending on the sugar substrate.  It catalyzes proton-melibiose, lithium-lactose, and proton/lithium-methyl-1-thio-beta-D-galactopyranoside (TMG) cotransport.  This protein seems to be lacking the ability to recognize sodium cations.
What are the official names of this protein?
Melibiose permease, Melibiose carrier, Melibiose transporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WTF5_SCHPO
Sequence: MKNNYTSLKSPLDEEDELKTDHEIDLEKGPLPEYDSEEESTLPPYSDHALVNNPPNTHRENHSYGTTDNSSPLLIILLISFTSIILFNAPEVCYLKYKDAFFKNYGAAEWTLFGFWCLVCTLALIFLTYFYETWTKAVKVTVISLAKCVKVTAIFLAQCVKACGKGIKHFLKKWENMPMAFSEVFLFNILVGSPRMNLRYIFGDRWGLKCSLADHIIFVVLSILVFIAETVKPGSIRVNLIRKMGYEAKQQVNEYTAVPLREMNSESEA
What is the function of this protein?
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (By similarity).  Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity).  Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
What are the official names of this protein?
Meiotic drive suppressor wtf5.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: RR3_HELSJ
Sequence: MDFISKTIGLRLGYNKTHKLIWSLSKNNPIFIQTNHFLEYIIKNDPFFCGLILIDFQLMQYIVVHKNQLGNFSPLKNNLPNSINLFLKLKIATEIQSNFNSVFILEERLHFLFFKYLNKMKNLKMLNNLKIKVKIKFLNNPILEPQWIFYKLHQDLYKGINIRRALAKISSNVIKKGAEGVKIQIKGRINGVDKATVIVEEKGKMPLQNLSSEINYYSRALKTVYGLLGVKIWVFKGFLLK
What are the official names of this protein?
Plastid 30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid.
Protein: PTH_THEPX
Sequence: MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLKPQTFMNSSGEALYDAVNFYKIPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYLLNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAVIKAADAVIDIIENGIEHAMSKFNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP4_ROTME
Sequence: MASLIYRQLLTNSFTVDLSDEIETIGSEKNQNVTINPGPFAQIGYAPVDWGPGETNDSTTVEPVLDGPYKPTSFNPPTDYWMLLSPSSPGAVVEGTNNTDRWLATILIEPNVASTTRTYTIFGSKEAITVENTSQNKWKFIDLAKTSLTGSYSQYGILLSKPKLYAIMKRSGYLYTYSGETPDAITDYYTTTNYDSVNMTAYCDFYIIPWAQEALCTQYINNGLPPIQNTRNVVARPLSSRSIVVRRAQANEDVVISKASLWKEMQYNRDITIRFKFANAIIKSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGVNNFDFFGGALPTDFVISRYEVIKENSFVYVDYWDDSQAFRNMMYVRSLAADLNSVMCTGGVYEFSLPVGQWPAMTGGAVSLRAAGVTLSTQFTDFVSLNSLRFRFRLSVEEPSFSITRTRVSGLYGLPAANPNNGREYYEVAGRFSLISLVPSNDDHQTPIMNSVTVRQDLERQLSELRDEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKATFDAVKSMATSVMKKFKKSGLASSVSTLTDSLSDAASSMSRSGSIRSISSNSSVWTDVSSTLYDLPSYMSTVSTQTATISKRLRLKEITAQTEGMNFDDISAAVLKTKIDRSAQITPNTLPDIVTEASEKFIPNRSYRILNNNEAFETSTDGRFFAYRVDTFEEIPFDVQKFADLVTDLPVISAIIDFKTLKNLNDNYGITREQAFNLIRSDPRVLREFINQDNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.