PharMolix/UniProtQA huggingface dataset:
Protein: EFG_PSE14
Sequence: MARTTPIGRYRNIGIVAHVDAGKTTTTERVLFYTGKSHKMGEVHDGAATTDWMVQEQERGITITSAAITAFWQGSEKQHKDQYRFNVIDTPGHVDFTIEVERSLRVLDGAVVVFCGTSGVEPQSETVWRQANKYGVPRIVYVNKMDRAGANFLRVIAQIKQRLGHTPVPIQLAIGAEDNFQGQIDLMSMEAVYWNDADKGMVPRREPIPAELQELADEWRSNMVEAAAEASEELMNKYLEGEELTNEEIKAALRQRTIAGEIVLAVCGSSFKNKGVPLVLDAVIDYLPAPTDIPAIKGSDPDNEEVLMERHADDNEPFSALAFKIATDPFVGTLTFVRVYSGVLASGDGVINSVKGKKERVGRMVQMHANAREEIKEVRAGDIAALIGMKDVTTGETLCNADKPIILVRMDFPEPVISVAVEPKTKDDQEKMGIALGKLAQEDPSFRVKTDEETGQTIISGMGELHLDILVDRMRREFNVEANIGKPQVSYRERITKNCEIEGKFVRQSGGRGQFGHCWIRFAPADEGQEGLQFVNEVVGGVVPKEYIPAIQKGIEEQMKNGVVAGYPLIGLKATVFDGSYHDVDSNEMAFKVAASMATKQLAQKGGGELLEPIMAVEVVTPEDYMGDVMGDLNRRRGMILGMEDTVSGKVIRAEVPLGEMFGYATDVRSMSQGRASYSMEFKKYNTAPSHIVETVTKKQG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPIF_BACSU
Sequence: MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFTQLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWRAEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL
What are the official names of this protein?
Uncharacterized protein YpiF.
Protein: RL31_PROM1
Sequence: MPKSDIHPTWYPEAKVICNGEVVMTTGATQPEIQVDVWSGNHPFFTGTQKILDTEGRVDRFMRKYRMASSDSSEQKDKSSEEKKES
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: S47A1_PONAB
Sequence: MEAPEEPAPVRGGPEATLEIHGSRFLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGAIGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATKLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGETQSDQQMRQEEPLPEHPQDSAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
What is the function of this protein?
Multidrug efflux pump that functions as a H(+)/organic cation antiporter.  Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively.  Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate.  May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier.
What are the official names of this protein?
Multidrug and toxin extrusion protein 1, MATE-1, Solute carrier family 47 member 1.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
Protein: FATD_BACAN
Sequence: MISRVENISQPQFYNHNKIWTKPFIIAIIVVIILGIISLFTGVYDIRGQEDGMEMFFITRVPRTVALMLTGAAMAMAGLVMQLITQNRFVEPTTTGTIEWSSLGLLFVYLLFPAPTLVQRMTGAIIFSFIGTMIFFLFLRRVKLRSSLIVPIIGLMLGAVISAVSTFLGLLFQMTQSIETWFVGSFANIQVGRYEYLWLIVIVTLLIFMYANRLTLAGLGEDVATSLGVNYNRIVLFGTALISVAVGIVAAVIGNLPFLGLIVPNIVSMFRGDDLRSNLPWVCVIGMGTITACDIISRTIIKPFELPVSLILASVGAVVFITILLRKRKPRRLR
What is the function of this protein?
Part of an ABC transporter complex involved in ferric-petrobactin uptake.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Petrobactin import system permease protein FatD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUB5_ARATH
Sequence: MRIDYTERMPQSYKMHSSMCLELKRLVDRIMRIFPDIEDARPGCSSGIQTLCLLHNALDKTKQLLQYCSESSKLYMAVTGDAILARGSRAKKSLEQCLNDIRSIVPTILEIKISQIVQDLRSTQLTLEFSEEEAGKAIRELMQKSTSSSASPDEIKDFHYAALKLQLSTPEAIVTERRSLKIICEDHKQNSFTHHQSIDDSLHANAAEAEASEEHNGTLPEKFKCTLSRTVMYDPVIISSGNTFERMQIQKWFDEGNDSCPISKRKLDDFTLKPNVELKSQISEWCAKNGLDVQDPARKHVKASNSIDFSVSIASFGSSLYNIPDHSGISITDFNSSYSIDSSSYSKMSKGGYFTPMQRIDSASGAGDTDSSHSEIEIDPLCGLTNLPWDAQIKVVEDVRSRFEHSTRAFRSMSPSKFLEPLITYLKNALERNGTAGEIIKGGLDLLLAFLSGNRRAIESLEEEVFKMFSVFLESEVVAEEALNILEVLSNHPHGPSKITSSGSLSSLLKIVESQAEHLQEQAMITLKNLSSSMEICLEMVSLDFIQKLTSFLQQKVFCKHSIIILKNLCSTEKGRGCITETPDCLASIAELLESNVPEEQENAISILLQLCVQKIEYCCLVVREATDIYSSLILISNNGTEEVKVSASELLRALVEVDSDKEEEEEVSSRPEGRTTASPTSQVVTPVTHPEPVKITPSPKKSGLFGFNFSSLKKKKK
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 5, Plant U-box protein 5, RING-type E3 ubiquitin transferase PUB5.
Protein: SYL_RICTY
Sequence: MHKIEQKWQKIWKEEKAFQVSNDSSKPKYYVLEMLPYPSGKIHIGHIRNYSIGDVIARFMTMQGFNVLHPMGWDAFGLPAENAAIQNNSRPQDWTYSNIEYMKKQLQSMGFSYDWTREINSCDPQYYKHEQKFFLELYDRDLVYQKESLVNWDPVDNTVLANEQVVNGRGWRSGAIIEKRYLNQWFLKITNYAEELLNEIQNLKDWPEAVRVMQEEWIGKSTGVNFHFKIKYHENSTIEVFSTKPETIFGASFIGIAFNHPIIEQLIFKTDEIANFITKCSYITKSSELEKSEKEGVFTGLYVIHPFDANIILPVIITNFVLMDYGTGAIFGCPAHDKRDHELAMKMNLPIKKVIGTDNTQEEVLINSDWLNGLTSSEAKQKVISKFETLGIGKRSVNYRLKDWGISRQRFWGCPIPIIYCETCGIVPVPYKDLPVTLPDDVSFDNNYNPLEHHPSWKHVNCPKCDNHAIRETDTFDTFFESSWYFTRYCNNNAVEMTDSKACNYWLPVDKYIGGIEHAVMHLLYARFFTKLMNEHHYVSIREPFKGLFTQGMVLHATYKDENNNWLYPAEVVKNGNEFFHKETNTRVVQGRIEKMSKSKKNIIDLETIQEQYSADAIRLFVLSDSPPEKDLQWSASGIEGCSRFIHKLDNMFEVISSLKDDMNNEINTELNRLIHFTIKHVADDIKTFSLNRAIARMRTLTNAIYCEISKDKIDVRTIKYGFNVLIQLLNPFIPHITEEIWQKLGNKERLYKSVFAEFDDSMLEFSTYIMAVQVNGKLRDTYEFNTDISEDEVKQITVNLPKIQKFLAGKEPNKIILVPRKIVNIII
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_VIBCM
Sequence: MALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFFEPLKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSDSPASAAREIEFFFPESEICPRP
What is the function of this protein?
(Microbial infection) Catalyzes the phosphorylation of dZDP to dZTP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENTS_SALPA
Sequence: MNRQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFIGLMVGGVLADRYERKKVILLARGTCGIGFIGLCVNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMLGGILLASGGVAWNYGLAAAGTFITLLPLLTLPRLPVPPQPRENPFLALLAAFRFLLACPLIGGIALLGGLVTMASAVRVLYPALAMSWQMSAAQIGLLYAAIPLGAAIGALTSGQLAHSVRPGLIMLVSTVGSFLAVGLFAIMPVWIAGVICLALFGWLSAISSLLQYTLLQTQTPENMLGRMNGLWTAQNVTGDAIGAALLGGLGAMMTPVASASVSGFGLVIIGLLLLLVLGELRRFRQTSPVSDAG
What is the function of this protein?
Component of an export pathway for enterobactin.
What are the official names of this protein?
Enterobactin exporter EntS.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDK_RICB8
Sequence: MTIQYTFSMIKPDAIKRNKIGQVNTYLENEGLKIVAQKMTTLTKYEAECFYDEHRARPFFDSLVEYITSGPVVLQVLKGMDAITLNRKVMGATNPAEAEAGTIRKDIGESIEANSIHGSDSENSAKREIKFFFKKSEIIE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_PSEA6
Sequence: MAKAPTKSTRKRAKRQVADGMAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAGTAAQDYGLKNLEVFVKGPGPGRESAIRALNAAGYKITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ALLA_ECOUT
Sequence: MKLQVLPLSQEAFSAYGDVIETQKRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the anaerobic utilization of allantoin as sole nitrogen source.  Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: RL18A_YEAST
Sequence: MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L18-A, Large ribosomal subunit protein eL18-A, RP28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR48_BRUMA
Sequence: MTAIPVKKKVQVSFVIRDEKEPMHRSGVNCLQYDAQTGRLFSGGSDTIIRIWKSPDRKDDSGSSYSVGGKTRVRRDLHLQSMEHHTDWVNDIVLCCGVISASSDTTVKVWNAQKGFCMSTLRTHRDYVRALAYARDVEMVASGGFDQLIYLWDIATLTKLTALNNTVTTSSLTGNKDSIYSLATNPSGTVVISGSTEKVLRVFDPRACQKLMKLRGHTDNVKAVVVNRDGTQCISASSDGTIKLWSIGQQCCISSLKCHSESVWALQVDSNFSCVYSGGRDKRIFRTAINDFKTAQLMFIEDAPVQRLQLIDSESRFIWTATWNSSIKRWPLPSDAQISVEIKSDQYGETIPSIHEPDLTIPGAASIRQHVVLNDKRHIVTKDTDDNVAMWDVLKGRKVCDHGKRPMEEVIKDHFKKVFVPSWFTVDLKSGMLQITLDESDFFSAWVSAKDAGFPNIQNDTKINYGGMLLRALFEHWSRSFSDVDEESPTHRFNSVPGHTPLILCESTGRPIFRLMIRDAAHETESQMLSDFVPPWVLDVVERNQLPKFNKMPFFLLPHLSLGIKTPKKDRLSATEMLQVRKVMEHVYEKILNVNDASYSENGIPSAAQMLSPSLQANIEERVELYCQDQKLDPEMDLRTVKHFIWKQGGDLMLYYKPIR
What is the function of this protein?
Regulator of deubiquitinating complexes.  Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity).
What are the official names of this protein?
WD repeat-containing protein 48 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR48 family.
Protein: MUKB_SALPC
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLSLAELKDKLDEMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRLTLEAIRVTQSDRDLFKHLISEATDYVAADYMRHANERRVHLDQALAFRRELYTSRKQLAAEQYKHVDMARELGEHNGAEGSLEADYQAASDHLNLVQTALRQQEKIERYEADLEELQIRLEEQNEVVAEAAEMQDENEARAEAAELEVDELKSQLADDQQALDVQQTRAIQYNQAISALARAKELCHLPDLTPESAAEWLDTFQAKEQEATEKLLSLEQKMSVAQTAHSQFEQAYQLVAAINGPLARSEAWDVARELLRDGVNQRHLAEQVQPLRMRLSELEQRLREQQEAERLLAEFCKRQGKNFDIDELEALHQELEARIASLSESVSSASEQRMALRQEQEQLQSRIQHLMRRAPVWLAAQNSLNQLSEQCGEEFTSSQEVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGAEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQIAEQLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPSLPIFGRAARENRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLSVAFEDDPEAEIRRLNGRRVELERALATHENDNQQQRLQFEQAKEGVSALNRLLPRLNLLADETLADRVDEIQERLDEAQEAARFVQQYGNQLAKLEPVVSVLQSDPEQFEQLKEDYAWSQQMQRDARQQAFALAEVVERRAHFSYSDSAEMLSGNSDLNEKLRQRLEQAEAERTRAREALRSHAAQLSQYSQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARQRRDELHAQLSNNRSRRNQLEKALTFCEAEMENLTRKLRKLERDYHEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADELRSMSDKALGALRLAIADNEHLRDVLRLSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQSVSFGQVNSVRLNVNVRETHATLLDVLSEQQEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDEARRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTQTEDTPSEAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: RS15_ECO45
Sequence: MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: Y315_NEIG1
Sequence: MKIVLISGLSGSGKSVALRQMEDLGYFCVDNLPLEMLPSLVSYHIERADETELAVSVDVRSGIDIAQAREQIAYLRGLGHRVEVLFVEAEEAVLVRRFSETRRGHPLSNQDMTLLESLKKEREWLFPLKEIAYCIDTSKMNAQQLRHAVRQWLKVERTGLLVVLESFGFKYGVPNNADFMFDMRSLPNPYYDPELRPYTGMDKPVWDYLDGQPLAQEMVDGIERFVTRWLPRLEDESRSYVTVAIGCTGGQHRSVYIVEKLARRLKGRYELLIRHRQAQNLSGR
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein NGO0315.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ILVD2_AROAE
Sequence: MPQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHAGMLYSLPSRELIADSVEYMVNAHTADALVCISNCDKITPGMLMAALRLNIPAIFVSGGPMEAGKVKWEAKVISLDLVDAMVKAADSSCSDAEVDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVLATHADREQLFLRAGRTIVDMARRYYEKDDASVLPRSIVTFQAFENAITLDVAMGGSTNTVLHLLAAAREAGVDFTMADIDRISRKVPCLCKVAPAVADVHIEDVHRAGGIMAILGELNRAGLLHAELPTVHSKTMAEALSRWDVMQAHDNAVFEFYKAAPGGVPTQVAFSQNRRWKELDMDRSHGVIRDRANAFTQEGGLAVLYGNIAEKGCIVKTAGVDESIWTFTGRVRVFESQEAAVEGILGDRIVAGDIVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHVSPEAACGGAIGLVEEGDSIEIDIPNRRIHLAVPDEVLTARRAAMNAKGHKAWKPEGRQRVVSAALQAYAALTTSADTGGVRDVTQVQR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 2, DAD 2.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CCND3_HUMAN
Sequence: MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
What is the function of this protein?
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739).  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739).  Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739).  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739).  Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892).  Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120).
What are the official names of this protein?
G1/S-specific cyclin-D3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TSR2_DANRE
Sequence: MAPLSSSTREVFSEAVRAVLETWPVLQIAVDNGFGGAFSQQKAEWMVDALQQYFTDNGDLQPDEVEDFISELMNNEFDTVVDDGSLPQVAQQVCGMFQQCEQGRLAEVREQILKLNQKKTSSGRAKATPAQTPQDDDDDDEEEAMDCEGGSAGASVSSTAVNDLHHEEEEDDGWTVVRRKK
What is the function of this protein?
May be involved in 20S pre-rRNA processing.
What are the official names of this protein?
Pre-rRNA-processing protein TSR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the TSR2 family.
Protein: ARLY_ACTP2
Sequence: MALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVVALKELRAEIESNIAIILRDDAEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMWCKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRAQPITFAHWCMAYYEMLERDFSRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLSTASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALSGLLTTLKGLPLAYNKDMQEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAAQQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKREPLEALSVAEFKQFHPVIDEDVYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAGE1_MACFA
Sequence: MSLVSQNSRRRRRRVAKATAHNSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTVSEGPGTSLLATPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPATPGEGTSTSVPPTASEGPSTSVVPTPDEGPSTSVQSTAGEGPSTPVPLTATEGLSTSVPDTPDEGLSTSVPPTATEGLSTPVPPTPDEGPSTSMPATPGEGRSTTMLPAASDGQSISLVPTPGKGSSTSGPPTATEGLSTSVQPTAGEGPSTSVPPTPCGGLSTSVPPTPGEGLSTSVPPTATEGLSTSVPPTPGEGPSTSVLPTPGEGRSTSVPPTASDGSDTSVPPTPGEGPSTLVQPTASDRPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSIVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSITIMGLSTPRVAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEARTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEICEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEQYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVASPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKEGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQSGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQFFVHNFR
What is the function of this protein?
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.  Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).
What are the official names of this protein?
Melanoma-associated antigen E1, Alpha-dystrobrevin-associated MAGE Protein, DAMAGE, MAGE-E1 antigen.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Cell membrane. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity).
Protein: BIG1B_ARATH
Sequence: MDPWDTYNIPLDHQHRLRNRRDHRHPSFSSTLLDQIYRSIDDSSTNSSSMRKTKHQNREDTRVSANRRDDFNRSKNLKTIEPVFFKHSSSSSSDSSGFSSSESDYFYRRSKSSPAISHPKPIRTTVERFERSPQNHRPNSSNKQEHGSFLKTKSKALKIYSDLKKVKQPISPGGRLATFLNSIFTGAGNTKKLNKINTTVTSTTAAAAAASSTTTCSSASSFSRSCLSKTPSSSEKSKRSVRFCPVNVIFDEDSSKYNNKNNKVYGNNEREYESIRHTLENRVMEENRRVIEAAKELLRSYQKKNKEVIEVSVEDDEEDDDDDALSCTSSDLFELDNLSAIGIDRYREELPVYETTRLNTNRIISR
What is the function of this protein?
Involved in auxin transport.  Regulator of the auxin signaling pathway.
What are the official names of this protein?
Protein BIG GRAIN 1-like B.
What is the protein family that this protein belongs to?
Belongs to the BIG GRAIN 1 (BG1) plant protein family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: AAXA_CHLCV
Sequence: MASFHSSLLTALCTLCTYGILTMPAYGLDPNHPKHHYHKYSERLKRSNAEDSAFYLSSASESSEDLRQEPRRHILTPVRNVLKDDPCDEGLSISKLLHSIEKETNSQISVDFTILPQWFYPKKSALATSEEKQPTWQFYVSPNISWQLYNSPTAGVGSIDFSYTLIRYWNNSAQNANNAIGIAGEINDYSSRTNTLSLLTFSQTFPGEMLTVSFGQYSLYSIDGTLYDNDQQCGFLSYALSQNASATYSSGSVGAYVQFTPIPSINIQAGFQDAYSIVGSSFDVYNLTKNRYNFYGYFSWAPQSCLGAGQYSALIYSTRNVPQQPVQTTGWSLNFGQYLGEKLYVFGRWNGSTGTAVNLNRSHVLGLASANPINRNPKDLLGAACSMSKVNPKVVTDKKIRKYETVIETFATVGFGPHLSLSPDLQVYIHPARRPDRRSATVYSIRANFFV
What is the function of this protein?
Facilitates L-arginine uptake, as part of the AaxABC system.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Porin AaxA, Outer membrane protein AaxA.
What is the protein family that this protein belongs to?
Belongs to the OprB family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.