PharMolix/UniProtQA huggingface dataset:
Protein: TCAM2_MOUSE
Sequence: MGVGKSKLDKCPLSWHKKDSVDADQDGHESDSKNSEEACLRGFVEQSSGSEPPTGEQDQPEAKGAGPEEQDEEEFLKFVILHAEDDTDEALRVQDLLQNDFGIRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVSRQHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVFERQQSIWKETRSVSQKQFIA
What is the function of this protein?
Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction.  In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4.  In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement.  Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response.  Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.
What are the official names of this protein?
TIR domain-containing adapter molecule 2, TICAM-2, TRIF-related adapter molecule, Toll/interleukin-1 receptor domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Cell membrane. Early endosome. Late endosome. Endoplasmic reticulum. Cell projection, phagocytic cup. Note=Localized to the plasma membrane as a result of myristoylation.
Protein: HMDH2_ARATH
Sequence: MEDLRRRFPTKKNGEEISNVAVDPPLRKASDALPLPLYLTNTFFLSLFFATVYFLLSRWREKIRNSTPLHVVDLSEICALIGFVASFIYLLGFCGIDLIFRSSSDDDVWVNDGMIPCNQSLDCREVLPIKPNSVDPPRESELDSVEDEEIVKLVIDGTIPSYSLETKLGDCKRAAAIRREAVQRITGKSLTGLPLEGFDYNSILGQCCEMPVGYVQIPVGIAGPLLLDGVEYSVPMATTEGCLVASTNRGFKAIHLSGGAFSVLVKDAMTRAPVVRFPSARRAALVMFYLQDPSNFERLSLIFNKSSRFARLQSITCTIAGRNLYPRFACSTGDAMGMNMVSKGVQNVLDFVKSEFPDMDVIGISGNYCSDKKASAVNWIEGRGKHVVCEAFIKAEIVEKVLKTSVEALVELNTLKNLVGSAMAGSLGGFNAHSSNIVSAVFIATGQDPAQNVESSHCMTMILPDGDDLHISVSMPCIEVGTVGGGTQLASQAACLNLLGVKGSNNEKPGSNAQQLARIVAGSVLAGELSLMSAIAAGQLVKSHMKYNRSSRDIGPSSQVNR
What is the function of this protein?
Catalyzes the synthesis of mevalonate.  The specific precursor of all isoprenoid compounds present in plants.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2, AtHMGR2, HMG-CoA reductase 2.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GET3_CANGA
Sequence: MDLTVEPNLKSLITSSTHKWIFVGGKGGVGKTTSSCSIAIQMALAQPHKKFLLISTDPAHNLSDAFGEKFDKDARKVTGMDNLSCMEIDPSAALKDMNDMAVSSAGENGNDDLGGLLQGGALADLTGSIPGIDEALSFMEVMKHIKKQEQGDGESFDTVIFDTAPTGHTLRFLQLPTTLSKLLDKFSEITGRLGPMLNSMMGSGNVDIAGKLNELKANVETIKEQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAEFDQEHNCKRCQSRWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLKKFSQFLFKEYDPVADNTVIYELEEKN
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting.  Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.  Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.
Protein: QUEF_MAGSA
Sequence: MGTGTEHLTQLGQSTALPASPDKAVLETVPNPHPGTLYLVRFTAPEFTSLCPITGQPDFAQLVIDYAPEGSLVESKSLKLFLGSFRNHGAFHEDCTIAIAKRLVAACAPKWLRIGGYWYPRGGIPIDVFWQTGPAPEGLWLPDQGVAGYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_POLNA
Sequence: MNINSTLFLQAVVFAILVWFTMKFVWPPITKALDERAQKIADGLAAADKAKSELSSANKRVEAELATSRTETATRLADADRRGQGIIEDAKARAVEEANKIIAAAQAEAAQQSVKAREALREQVALLAVKGAEQILRKEVNAGVHADLLSRLKTEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HISZ_AGRFC
Sequence: MPLIDMPEFAGELLEEFAARRTSRVNTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLCLRPEFTIPVCLRHIETATGTPKRYSYLGEVFRQRREGASEFYQAGIEDLGDTDIAAADARVVIDATAILQRLLPGRSLAVTLGDQQVFEAVVAALGLPLGWQKRLVQAFGDMAQLDALLESLVHPKPMTGLDARVAGLLATGDEAVLVDYLDTVMQETGYSTNASRSPLEIARRLREKLALAATRLPDESFELLKQFLALQAPLPQASQVLGDFAARAKLKLDGALSAFDKRVAALANAGVDLETVTYGAAFGRPLDYYTGLVFEVVEAGSDSVLAGGGRYDRLLTLLGAQEKIPAVGFSLWLDRIKAVRGSDKP
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDT2_ARATH
Sequence: MSASSSSTNPMSREDATTLLPSVQDKYGGVMTEMTHPMDPSLFSTLLRSSLSTWTLQGKKGVWIKLPKQLIGLAETAVKEGFWFHHAEKDYLMLVYWIPKEDDTLPANASHRVGIGAFVINHNKEVLVVQEKTGRFQGQGIWKFPTGVVNEGEDIHDGSVREVKEETGVDTEFDQILAFRQTHKAFFGKSDLFFVCMLKPLSLEINAQESEIEAAQWMPWEEYINQPFVQNYELLRYMTDICSAKTNGDYEGFTPLRVSAPDQQGNLYYNTRDLHSRN
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.  In vitro, it can use both NADH and ADP-ribose as substrates; however the relevance of such substrates in vivo is unclear.  Confers tolerance to oxidative stress (PubMed:18798872).
What are the official names of this protein?
Nudix hydrolase 2, AtNUDT2, ADP-ribose pyrophosphatase, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: MATK_ERYGA
Sequence: MEELQGYFKKARSLQQHFLYPLLLQEFIYTLAYDDGLKGSIFYEPIEFFGYDNKSSLVLIKRLITRMYQQNFLIYSVNDSNQNGLRGHINYFYSHFFYSHIVSEGFSVIVEIPFSLRLVSSPKEKEIPKSQNLRSIHSIFPFLEDKLSHLNNVSDILIPHPIHLEILVPILQYWIQDVPSLHLLRFFLHKYHNLNSFIQNNKTIYVFSKENKRLFWFLYNSYVSECEFLLVFLRKQSCYLRSTSSVAFLERSHFYGKMEHIIIVCCNNFQKTLWPFKDPFMHYVRYQGKAILASRGAHLLMKKWRYYLVNFWQYYFHFWSQPYRMHINPLLNYSFYFLGYLSSVLINPYAVKNKMLENSFLIDTVFKKFDTIIPIIPLIGSLSKAKFCTVSGHPISKPVWGDLSDFDIIDRFGRICRNLSHYHSGSSKKQSLYRIKYILRLSCARTLARKHKSTARALLQRLGSGLLEEFFTEEEQVLSFIFPKTTPFPLHGSHKERIWSLDIIRVNDLVNQII
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDM10_LACTC
Sequence: MIDYMEHVLRSFEQCTGWNRDNSYENVTATSENLLSFRVPSGVKFQVSNKSTPNTFTTFELSNNKVINGSLAYLYTNCQGLENYVSNSRDILLQEASETYRQIRPLYPCHSLRSSSDGAKEFGPSSLWYGRMYYPTSTLEAMVVSRSSAQTQFVAKCISSLANASVLTLYWQKDSGQNCQEWVASTNEGLLGYRILHNFVGSQSKLNTSLYNDSSLSVGGELWFGVLNTTPACSTTLRYCTHSANTGKPLTLTLSWNPLFGHVSSTYSVKTSSGATFSSKYDFNLYSIESNLSFGCDLWRRGHTKQLDQRRTEPLDAPNTNSSVFSKERVQKKQGPKEDSPMFYHLMAGSTSSQKLIEDLNVTFASSLQKLTKEKSTIQRFENSLIDANFASVWKLSTSLRHKNLRVLWEGKYKGFLISAGAEFTGAPLELPSNLAGESKTPALIRPGKFGIQLQYST
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: P4H5_ARATH
Sequence: MASKSKQHLRYQPRKSVSRSTQAFTVLILLLVVILILLGLGILSLPNANRNSSKTNDLTNIVRKSETSSGDEEGNGERWVEVISWEPRAVVYHNFLTNEECEHLISLAKPSMVKSTVVDEKTGGSKDSRVRTSSGTFLRRGHDEVVEVIEKRISDFTFIPVENGEGLQVLHYQVGQKYEPHYDYFLDEFNTKNGGQRIATVLMYLSDVDDGGETVFPAARGNISAVPWWNELSKCGKEGLSVLPKKRDALLFWNMRPDASLDPSSLHGGCPVVKGNKWSSTKWFHVHEFKV
What is the function of this protein?
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins.  Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins.  Possesses high affinity for leucine-rich repeat and proline-rich extensins of root cell walls that are essential for root hair development.  Hydroxyprolines define the subsequent O-glycosylation sites by arabinosyltransferases which elongate the O-arabinosides on extensins.
What are the official names of this protein?
Prolyl 4-hydroxylase 5, AtP4H5.
What is the protein family that this protein belongs to?
Belongs to the P4HA family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Predominantly localized in the endoplasmic reticulum.
Protein: YBEA_LACLA
Sequence: MSFTDETVRFEFGDSDKKEIGETLVDVYNVLEAKGYNPINQIVGYVLSGDPAYIPRHDDARNKIRRFDRDDIVEELIKNYLKDNGVNL
What are the official names of this protein?
UPF0297 protein YbeA.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RS17_THESQ
Sequence: MPRKRLTGIVVSDKMDKTVVVAVEKLVQHTIYKKYVKRTKKYHAHDERNECKIGDVVEIEETRPLSKTKRWRVVRIIQRFEPERVLKEEEDIQEEIEAVEGKGGVES
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RNY_CHLL3
Sequence: MGIVINLFLIIFASVVFFAAGFFLGRFFLERLGTTKVLEAEERAVQIVQEAQKEANEYKELKVTEVNQEWKKKRREFDQEVVIKNNKFNQLQKQVQQREAQLKKQLQDVRDTERKLQDQQKELDQAMETVGIRATELERIITEQNQRLESISNLQADEARQMLVDNMITKAREEATETIHKIHEEAEENAGRLAEKTLLTAIQRISFEQATENALSVVHIQSDELKGRIIGREGRNIKAFENATGVDIIVDDTPEVVILSCFDPLRREHAKLTLKKLLADGVIHPVAIEKAYLDAGKEMADVIMSAGEEALASLQIPDMPAEIVRLIGTMKFHSVYGQNLLQHSREVAMLAGIMATELKLDPRLAKRAGLLHDIGLVLPDTDQPHALAASEFLRKFKESAVVLNAIAAHHGEAEKESPIAELVDAANVISLARPGARGAVTADGNVKRLESLEEIAKGFPGVLKTYALQAGREIRVIVEGDNVSDSQADVLAHDIAHKIESEAQYPGQIKVSIVRERRSVAYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RUVA_PROM4
Sequence: MIGWLKGEKIDHWNNGNRAGFVLSCNGVGYEIQLSRRNLIALNNYNVLSIWIHQVLKEDGSNLFGFIEKSERDLFRKLITVSGVGPQLAMSLLDDNSYEQLIANVQNKEVTKLTRSSGVGKRTAERLILELQNKLSDFDLNNEFSPPTKLRPESAEDLNEELLTEIKSALRNLDYSDFEILEAVNTVTSNYLDDAASANERKLLLKSLNFEKLFKQALITLNK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PAK4_HUMAN
Sequence: MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival.  Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.  Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.  Decreased cofilin activity may lead to stabilization of actin filaments.  Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin.  Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility.  Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers.  Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD.  Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner.  Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
What are the official names of this protein?
Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.
Protein: RK5_OLTVI
Sequence: MAQRFKELYLQTIVPKLKDEFGYKNSHQVPEIKKIVINRGLGDASQNAKILDSSLNELSIIAGQRGVVTRSKKAIAGFKLRDKMAVGISVTLRGDRMYSFLDRLINLALPRIRDFQGISPKSFDGCGNYSLGLEEQLMFPEIDYDKIDQVRGMDISIVTTCSNNEEGVALLKNFGMPFKA
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GCH1_YERE8
Sequence: MSSLSKEAELVHEALLARGLETPLRKQELDAETRKTRIQEHMTQVMQLLNLDLSDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHNG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: URK_STRS7
Sequence: MLKKPIIIGVTGGSGGGKTSVSRAILNSFPNARIAMIQHDSYYKDQSHISFEERVKTNYDHPLAFDTDFMIQQLKELLAGRPVDIPIYDYKEHTRSNRTFRQEPQDVIIVEGILVLEDERLRELMDIKLFVDTDDDIRIIRRIQRDMVERGRSLESIIEQYTSVVKPMYHQFIEPSKRYADIVIPEGVSNVVAIDLINTKIASILGEL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_CALS4
Sequence: MIFDVLTLFPEMFECVLSHSILKRAVEKSKLKVNLINIRDFSKDKHKRVDDYPYGGGPGMVMMPQPLFDAIEFVKSQGNIPVYYLSPKGKIFTQEMARELSKMERIALLCGHYEGIDERVYAVIDGEISIGDFILTGGELAAMVVIDAVTRLIDGVLSHPQSALEESFSDYLLEYPQYTRPEVFRGMRVPEVLLSGNHAEIARWRRQKSLEITLLKRPDLLKKANLTEEDKKFLREKGYEI
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_THEBR
Sequence: MAKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIELEDPFENQGAQLLKEAATKTNDIAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIAKAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGKLIAEAMDKVGKDGVITVEESKTLGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKISNIQDLLPLLEQIVQQGKKLLIIADDVEGEALATLIVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVRLDMLGRARQVKVTKEYTTIVGGAGDPSEIKKRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAATKAAVEEGIVPGGGIALLNVIEDVQKVVDSLEGDFKTGAKIVLRALEEPVRQIATNAGVDGSVIVEKIKAAKDPNFGYDAYKEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAIVVDIPEKNTGMPNPGAGMDMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTDT_SHIBS
Sequence: MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVFGFSNSVIWLIFAAFMFGTGYEKTGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQPNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGMLPLSILLVLLVPWLAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLWIFGGDYIDAAMVGYSVVALMLLLRIISWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLLWMPVVLL
What is the function of this protein?
Catalyzes the uptake of tartrate in exchange for intracellular succinate.  Essential for anaerobic L-tartrate fermentation (By similarity).
What are the official names of this protein?
L-tartrate/succinate antiporter, Tartrate carrier, Tartrate transporter.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL20_BUCAI
Sequence: MARIKRGVIAHARHKKILKQAKGYYGARSRIYRVAHQAVIKAGQYAYRDRRQRKRQFRQLWISRINAAVRQSKMSYSNFIFGLKKASINIDRKILSDIAIFDLLSFNALVKKAKEALL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: LYSET_MOUSE
Sequence: MPKAPDCSELSDSCSLAGGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHILQHPEEPREGTTWTHSLKARLLSLPFWLWTIIFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT
What is the function of this protein?
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes.  LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB.  GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes.  LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity).  Plays an essential function for cells that depend on lysosomal catabolism to generate nutrients (PubMed:36074821).
What are the official names of this protein?
Lysosomal enzyme trafficking factor, Transmembrane protein 251.
What is the protein family that this protein belongs to?
Belongs to the LYSET family.
Protein: RS6_GLOC7
Sequence: MTKSYEMVYILRPDLLEEQVQQEINRYRDFLTENEAQEVQIKYWGKRRLAYPIKKLQDGFYVQMNYQGDGKQIAPLERMMRLSDEVIRYLTIKLDKDQYTPNDSPPPEGIIDTPKPVIEPPKPAVESPKPAETTEETAEAVETVEPPAEPAEPVEAVETVDTTEETVEPVDTTSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.