PharMolix/UniProtQA huggingface dataset:
Protein: NIAP_ACIAD
Sequence: MDLVSRIENLPIGKFHYTLLWVVGLGWMFDALDTGIIAFIMTTLVKDWALTPAESGWIVSIGFIGMALGAVFSGGLADRFGRKTVFATTLLIYSLATAACAFAPNLTWLLAFRFIVGLGLGGQLPVAVTLVSEYIPAHVRGRFIVLLESFWGLGWLVAALVSYFVIPHFGWHIAFLIGGLPAIYVYVIIKKVPESIPYLINRGRIDEAHELVQQIERHAGVPVIDTIVVKPVAQKQQVSFRQLWSGRFARRSLMLWLVWFGIVFSYYGIFTWLPSLLVKQGYSVVQSFEYVLIMILAQLPGYISAAWLVERLGRKATLAGFIGACAISAYFFGQADTVFNIMVWGCLLSFFNLGAWGVLYTYTPEQYPANIRAFGAGWASAVGRMGGIAAPIVVTHMMVAHDGFHQVFMMFTLVLLAVAAVIVILGEETQGKTLESIGL
What is the function of this protein?
Functions as a high-affinity transporter of niacin (nicotinamide or nicotinate) (PubMed:20926389).  Probably substantially contributes to niacin transport when its concentration in the medium is very low (PubMed:20926389).
What are the official names of this protein?
Niacin transporter NiaP.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Protein: BTUB_SALPA
Sequence: MIKKATLLTAFSVTAFSAWAQDTSPDTLVVTANRFQQPRSAVLAPVTIVTRQDIERWQSTSVNDVLRRLPGVDIAQSGGAGQNSSIFIRGTNSSHVLVLIDGVRLNLAGVSGSADLSQFPVSLVQRIEYIRGPRSAIYGSDAIGGVVNIITTRDNPGTELTAGWGSNSYQNYDISTQQQLGENTRATLIGDYEYTKGFDVVAKGGTGMQAQPDRDGFLSKTLYGALEHTFSDRWSGFVRGYGYDNRTDYDAYYSPGSPLIDTRKLYSQSWDAGLRFNGERIQSQLVSSYSHSKDYNYDPHYGRYDTSATLDEMKQYNVQWTNSVVVGHGNVGAGVDWQKQTTTPGTGYVPEGYDQRNTGVYLTGLQQLGDFTLEAAARSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQLYGYYGNPNLNPEKSKQWEGAFEGLTAGVSWRISGYRNDINDMIDYDDHLQKYYNEGKARIKGIEATANFDTGPLTHTVSYDYVDARNAITDTPLPRRSKQMAKYQLDWDVYDFDWGVTYQYLGSRYDSDYSAYPYRTVKMGGVSLWDLTVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: FIBER_BPT3
Sequence: MANVIKTVLTYQLDGSNRDFNIPFEYLARKFVVVTLIGVDRKVLSINADYRFATRTTISLTKAWGPADGYTTIELRRVTSTTDQLVDFTDGSILRAYDLNVAQIQTMHVAEEARDLTADTIGVNNDGHLDARGRRIVNLANAVDDRDAVPFGQLKTMNQNSWQARNEALQFRNEAETFRNQTEVFKNESGTNATNTKQWRDEANGSRDEAEQFKNTAGQYATSAGNSATTATQSEVNAENSATDADNSRNLAEQHADRLELEADKLGIFNGLAGRIDKGDGTNVYWKGGIHANGRLYLTSDGFDCGQYQQFFGGSAGRYSVMEWGIEKAWLMHVERRERTTAIVDNIQLVVNGHIIAQGGDMTGPLKLQNGHALYLESASDKAQYILSKDGNRNNWHIGRGSDNNNDCTFHSYVYGTNLTLKPDYAVVNKRFHVGQAVVATDGNIQGTKWGRKWLDAYLNDTYVKKTMAWTQVWAAASDSYMGGGSQTDTLHRTCDSATYGLRPETTIGTSSELVLTVSTSFQPRRWLKFQIHSNGRVFKNIADRAATPTAIAVEDV
What is the function of this protein?
Structural component of the short non-contractile tail.  The tail comprises six fibers made of gp17 trimers, 2 nm in diameter and 32 nm in length.  May attach to host lipopolysaccharides (LPS) to mediate primary attachment to the host cell.
What are the official names of this protein?
Tail fiber protein, Gene product 17, Gp17, Tail fiber protein gp17.
What is the protein family that this protein belongs to?
Belongs to the T7likevirus tail fiber protein family.
What are the subcellular locations of this protein?
Virion.
Protein: MNMA_THEFY
Sequence: MTLRVLAAMSGGVDSAVAAARAVEAGYDVTGVHLALSSNPQSYRTGARGCCTIEDSRDARRAADVIGIPFYIWDMAEEFDRDVVQDFVAEYAAGRTPNPCLRCNEKIKFQAVLERALALGFDAVCTGHHVRLENGRLRRSVDAVKDQSYVLAVLTREQLAHAIFPLGDCTKEEVRAEAARRGLTVADKPDSHDICFIADGDTSGFLERRLGSNPGPIVDETGQVVGEHRGAHAFTVGQRRGLNLSGAPHRRYVLSIEPVSNTVRVGPREALQVDRIVGERPVWSGCEPPEEWTPFLVQLRAHGEVYSCRARQYEGRVEILLDEPALGVAKGQAAVLYDGDVVMGSSTIAETSRVEQAAANHAE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHYS_PYRAE
Sequence: MREIIELYRKVGGFQALHVAEAYDVLKEAVEAADVRFLSFTGNLVATGLREFIADAIRRRLFNVVVTTAGALDHDIAKSMGAVYAPGSFDLDDVDLAAKGYHRLGNVVIKKEEYGPLVEKFILAHCEKLWGKTLATYELAYLLGAELPEDSILGAAARAGAKVFVPGIVDGAVGTALMTCNDLARTKRGGSRAFIDVLKDEEELREIVHNSKKLAALIVGGGISKHHVIWWAQFKGGLDYVVYISTAVEYDGSLSGARPREAISWGKVKPSAKSVFIFADATLVLPVLLKAL
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
What are the official names of this protein?
Probable deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: AMPP2_NEUCR
Sequence: MTTTAARMDFETTLKGKYPAKRHAQRVADYIRNKMPGASGVLYLEGRATKLLEDNDEAEPFRQRRYFYYLTGCPLADCHYMYDLDADKSTLFIPPIDPDSVIWSGLPVSVDEAKQRWDVDDVKYTSDVNATLAHVGSSKPKGSSVFALANQVSDKVTFLEFDNKNFSILKEAIEVTRVVKDEYELAIMAKANEISSDGHKMVMQKVKHVQNERELEAVFLGHCIAKGARNQAYHSIVASGRAAATLHYVPNNADMAGKLNLLLDAGGEWDCYASDITRTFPINGKFTKESREIYDIVLKMQNECIAALKEGVLWDDVHLLAHKIAIDGLLQIGILQGDKDEILESRTSVAFFPHGLGHYLGMDTHDTGGNPNYADKDTMFRYLRVRGRLPAGSVITVEPGIYFCNFIIEPFLKDPKHSKYINADVLEKYWDVGGVRIEDNLVITKDGTYNLTTAPKDPEEMEKIIQQS
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase NCU11288, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: YQGF_BRASO
Sequence: MPAPILPLIEAAGRWPERGALVGLDLGTKTIGVAVSDPDRRLATGVETIQRKAFKADAARLLAICAERKVVGFVLGLPINMDGSEGPRAQSTRAFARNLAGLTDLPIGLWDERLSTAAVERELIGMDVSRAKRAEVIDTHAAIFILQGALDRLTTLRRSGQ
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_XENLA
Sequence: MKLNISFPATGCQKLIEVEDERKLRTFYEKRMATEVAADPLGDEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVRKGEKDIPGLTDNTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLAKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTQKNKEEASEYAKLLAKRSKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
What is the function of this protein?
Component of the 40S small ribosomal subunit.  Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: SURE_GEOUR
Sequence: MKILLTNDDGVRAPGLAALAEAMGAIGEVYVVAPDREQSAVGHALTLHHPLRATRIENNIFAVDGTPTDCVNLGIHSLLSFKPDIVVSGINRGGNLGDDITYSGTVSAAMEATLMGIPAIAVSLVTQNDGGNYSAAAAFVVKLAGIVSREGLPDDTFLNVNVPDLPAEQLRHPVITTQGKRSYEGTIVDKVDPRGRSYYWIGTVDLNFSDIEGSDYNAVSRGHISITPLHLDLTNYNSLAALKRWDLT
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAMP_HIPHI
Sequence: EPIDLLGKVFVFSKESNVDDVKLLTPQTE
What are the official names of this protein?
Serum amyloid P-component, Agarose-binding protein, Hh-ABP.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRP28_NEOFI
Sequence: MDGIISNGSPGASVTRPLPEPLEKPPTPPPPPPEDSAAPPPPPDTSVPPPPPEDAPPAPPPEKKKKVGWGAKRPAATPLSVEELVRKKREADAAAAKPKFLSKAERERIALEKRAKEVEAGRRFKSEPSTNGTDRSGTQSPSVYSETPNGDERSIPTGPRAMRNSEVPTGPAAMRNKNYDMSPPPPPKPMSFSLTDGKGDSKRQAEEDEAAAQAALIKQKYMGTEKTSSFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQQRHEANFYGRGRLAGFGDDVADTLAQKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDQVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYISELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEARKFTQPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKQMGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMANSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPNRGFAKKSDDSSGFGNKSGWQ
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase prp28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RK20_PLETE
Sequence: MTRVKRGNVARKRRKKILKITKGFRGSSSTLFRTANQQQMKALRYSYRDRLTRKRNFRALWIVRINAMARHLGLNYNQFINNITKAQIIINRKTLSQLAIYDSTIFSSLISIKNN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CE170_MOUSE
Sequence: MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASMDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFGYDTNLFTVVRGEMRVPEEALKHEKFTIQLQLSQKSSESELPKSASAKGTDSKVEAAAEVQPRATEALKSEEKPMDVSAMPRGTPLYGQPSWWGDAEEDEQRAFKANGKPEGKSQEAGASGCSTEAKHVEGQSAAASEEALFPFCREPSYFEIPTKEFQQPSQIAESTIHEIPTKDTPSSHTAGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKASPGTQDLPGIQTGMMAPENKVADWLAQNNPPQMVWERTEEDSKSIKSDVPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEQKKKAQSTEKHQEQAATSSTHHRGGHGVPHGKLLKQKSEEPSVSLPFLQTALLRSSGSLGHRPSQEMDVMLKNQATSASSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVFGVDDNQDYNRPIINEKHKGLIKDWALNSAAVVMEERKPLSTPGFHNSEEAISSSGSKRWVSQWASLAANHTRHDPEERLMELSATVENETDTGDAGVSLRSTSCTTSLASQGERKRRTLPQLPNEEKLLESSRAKVVPQRSEIGEKQDTELQEKEAQVYQSEKHDADRGLSKMSRAVNGESPKTGGDGKALLHSGSSSSKEKSETEKETSLVKQTLAKMQQQEQKEQAQWTPTKFPSKNALGHIDKCREESSKQESQLLEKVSGHSTSKGDRVIQNESKRRKAEEIPKCQASKGDKKESSKSLVRQGSFTIDKPSSNIPIELIPHINKQNSSVPTALALTSASRLRERSDSLDTDSSMDTTLILKDTEAVMAFLEAKLREDNNKTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTSSPSKDVTKSGSREKIEKKAKSRSADIGARADGRKFVQSSGRIRQPSIDLTDDDQTSSVPHSAISDIMSSDQETYSCKSHGRTPLTSADEHNIHSKLEGGKATKSKTSPVASGSTSKSTTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRTISRIDLLAQPRRTRLGSLSARSDSEATISRSSASARTAEAVIRSGARLVPSDKLSPRTRANSISRLSDSKVKSMSSTHGSPSVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRMQSTGSAMPASSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREEVGDLHGEMHKLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSVDSRPQPAEHPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSRKIRQSIDKTAGKIRILFKDKDRNWDDIENKLRAESEVPIVKTSSMEISSILQELKRVEKQLQVINAMIDPDGTLEALNNMGFPNAILPSPPKQKSSPVNNHSSPSQTPALCPPETRALHPAAAGVAAAASTEFENAESEADFSIHFNRFNPDGEEEDVTVHE
What is the function of this protein?
Plays a role in microtubule organization.  Required for centriole subdistal appendage assembly.
What are the official names of this protein?
Centrosomal protein of 170 kDa, Cep170.
What is the protein family that this protein belongs to?
Belongs to the CEP170 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis (By similarity). Localizes to the distal appendage region of the centriole (By similarity). Localizes at the centriole proximal ends (By similarity).
Protein: FABZ_PELTS
Sequence: MLDINQIKEIIPHRYPFLLVDRILSVEDGRKAVGLKNVSANEPYFQGHFPGYPVMPGVLIIEAMAQVGAVAVLRLPEFAGKMAFFAGIDRARFRRQVVPGDQLRIEVELQKLRGTVGKARGAAYVGQELAAEAELMFAVR
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTC_CHICK
Sequence: METLFRLPFAVLECPNIKLKRPGWVHMPSAMTVYALVVVSYFLITGGIIYDVIVEPPSVGSMTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVSVLLSFFMARVFMRMKLPGYLMG
What is the function of this protein?
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Oligosaccharyltransferase complex subunit OSTC.
What is the protein family that this protein belongs to?
Belongs to the OSTC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEXA_LACAC
Sequence: MSRKNSDTKQLEILRYIYDTVENRGFPPTVREICAAVGLSSTSTVHGHLSRLERKGFLIKDATKPRALEITAEGKTELGIKPKEIPVVGVVTAGQPILAVEDISEYFPLPPDLESDAGELFMLKVHGNSMIKAGILNGDNVIVRKQSTANNGEIVVAMTDENEATVKRFFKEDDHYRLQPENDTMAPIILQQVSILGKVVGLYRNNIQ
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ODPB_HUMAN
Sequence: MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, PDHE1-B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: IF1_MYCPN
Sequence: MQPKFNNQAKQDKLVLTGKILEIIHGDKFRVLLENNVEVDAHLAGKMRMRRLRILPGDLVEVEFSPYDLKLGRIIGRK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPM1B_RAT
Sequence: MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENVKTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPTHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPMEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCEFVNSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFANAPKVSDEAVKRDLELDKHLESRVEEIMQKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPNKDNDGGAGDLEDSLVAL
What is the function of this protein?
Enzyme with a broad specificity.  Dephosphorylates PRKAA1 and PRKAA2.  Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'.  Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity).
What are the official names of this protein?
Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
Protein: RTCB_HUMAN
Sequence: MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low.
Protein: UVRC_CLOBJ
Sequence: MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEGAKAIRPCLNYQIGLCKAPCAQYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIGEKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPNIEDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDLILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPE_EDWI9
Sequence: MEQFETIAVAQAQQMLAQGQALLLDIRDAQSYAAGHVPGALHLTDATLPALMRQHDGVQPVMVMCYHGNSSRGAAQYLLHQGFDEVYSIDGGFDAWQRAYPEEVARGGD
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_NOCFA
Sequence: MIDPTLRGAYRPGQLTVHHDPAVLGSVAKALRGVGRTVALVPTMGALHQGHLQIVRQAKRTNQVVIVSIFVNPLQFGAGEDLDKYPRTLDADVELLRAEGVELVFAPNAEQMYPDGPRTTVHPGPLGAELEGASRPTHFAGMLTVVAKLLQIARPHQAFFGEKDYQQLTLIRQMVRDLNFDVRIVAVPTVRESDGLALSSRNRYLDAAQRETALALSAALSAGAHAGGLGAEGVLAAARAVLDATPGLDLDYLELRSSTLGPAPASGNARLLVAAKVGTTRLIDNIAVTLGAPIDGHPNLDSQPEPAGTDPALLPPAR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_AERHH
Sequence: MSKTLLVMAGGTGGHVFPGLAVADRLKAQGWTIHWLGTADRMEAELVPAHGYPISFIDIQGVRGNGIKRLLVAPYRIVKSVLQARRVLKTIRPDVVLGMGGFASGPGGVAAWLSGIPLLLHEQNAAAGLTNKLLARLAKRVLMAFPGAFAPSRRTAVVGNPVRPEVVALPDPQLRSGAEPLRLLIVGGSLGARVLNEQVPPAVAAAGVPIEVRHQCGKGNRDAVAEAYAKQGVAAEVSEFIKDMAGAYAWADLVVCRAGALTVSEVAAAGVAAIFVPLPHAVDDHQTRNALTLVDGGAAEFLPQSELTTASLAARLSWLAGRRETLLNMAQAARRVAITDAAERVADECKRLATGQIEREL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.