PharMolix/UniProtQA huggingface dataset:
Protein: SYD_STAS1
Sequence: MSKRTTYCGLVTESLLDQEVTLKGWVHNRRDLGGLIFVDLRDREGYVQIVFNPDFSEEALKTAETVRSEYVVEVKGLVKKRDPQTVNPKIATGQVEVQVSEINIINKSETPPFAINEENQNVDENIRLKYRYLDLRRQELAQTFKMRHQTTRSIRQYLDKEGFFDIETPVLTKSTPEGARDYLVPSRVHDGEFYALPQSPQIFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDIEMSFVDQEDVMDMGEEMLQNVVKDVKDVEIPRPFPRMTYNEAMERYGSDKPDTRFEMELINVSELGEEMDFKVFKDAVNNDGQVKAIVAKGAADQYTRKDIDALTEFVNIYGAKGLAWVKVVDDGLSGPIARFFETTHIEKLQSLTNAESGDLVLFVADKPNVVAQSLGALRLKLARELDLIDESKLNFLWVTDWPLLEYDEDLKRYTAAHHPFTAPKQEDIEKLDSEPENAQANAYDVVLNGYELGGGSIRIHNGELQAKMFEVLGFTEEQAQEQFGFLLDAFKYGAPPHGGIALGLDRLVMLLTGRTNLRDTIAFPKTASATCLLTDAPSEVSENQLEELSLRIRH
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_CLOK1
Sequence: MIKSGFITIIGRPNVGKSTLLNSIMGEKLSIVSCKPQTTRNSIQTILTRDDFQLIFVDTPGIHKPKHKLGNYMVKVAESSVKDVDLILFLITPDVEVGKGDRYILEQLKKENIPVFLVVNKIDENPQEKVAQTLKNYSEIFDFAEIIPISALKQKNVKELVELMVKYMPEGPKYYPDDMITDKQEKFVVSEIIREKALRLLSKEVPHGIAVDILSMKKNSKGLYNIEATILCEKESHKGIIIGKKGAMLKKISTYAREDIEKFLDSKVYLEVWVKVKKEWRDSDRLLKELGYK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: LMP2_EBVB9
Sequence: MGSLEMVPMGAGPPSPGGDPDGYDGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVTATGLALSLLLLAAVASSYAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSLLFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGIMFLACVLVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKILLARLFLYALALLLLASALIAGGSILQTNFKSLSSTEFIPNLFCMLLLIVAGILFILAILTEWGSGNRTYGPVFMCLGGLLTMVAGAVWLTVMSNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV
What is the function of this protein?
May be a negative regulator of isoform LMP2A.
What are the official names of this protein?
Latent membrane protein 2, Terminal protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae LMP-2 family.
What are the subcellular locations of this protein?
[Isoform LMP2A]: Host cell membrane; Multi-pass membrane protein. Note=Isoform LMP2A is localized in plasma membrane lipid rafts. SUBCELLULAR LOCATION: [Isoform LMP2B]: Host endomembrane system; Multi-pass membrane protein. Host cytoplasm, host perinuclear region. Note=Isoform LMP2B localizes to perinuclear regions.
Protein: ARLY_GLOC7
Sequence: MTEKKTWSDRFEGSLHPAIAYFNASIEFDIELIEYDLTGSIAHAKMLAHTGIISETEAQQLVTGLEQIRAEYREGQFNPGIDQEDVHFAVERRLTEIIGDVGKKLHTARSRNDQVGTDIRLYLRDQIDQIRGQIREFQQVLLDHAQNHVETLIPGYTHLQRAQPVSLAHHLLAYFHMAQRDWERLGEIRKRTNISPLGSGALAGTTFPIDRHYSAQLLQFEGVYPNSLDGVSDRDFAIEFLNAASLIMVHLSRLSEEMILWSSQEFSFITLTDSCATGSSIMPQKKNPDVPELIRGKTGRVFGHLQGLLVLMKGLPLAYNKDLQEDKEALFDGVKTVKGCLEAMTILLSEGIKFKTERLTQAVNEDFSNATDVADYLAARGVPFREAYNLVGKVVKTSLAAGKLLKDLTLDQWKELHPAFEADIYEAIAPSQVVAARNSYGGTGFKQVRQAILTAKTLLESN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_BARHE
Sequence: MARQSKKKGRPVSGWIILDKPKGMRSTEAVSQIKYLFHAQKVGHAGTLDPLASGLLPIALGEATKTVPYVMQGTKTYRFHIAWGEERSTDDLEGEITHTSSKRPTREEILALLPQYTGVILQTPPQFSAIKIAGNRAYDLAREGEVVEIPPRQVEIETFKLIEMITKDHSIFEITCGKGTYVRSLARDMGRDLGCYAHIADLRRIAVAPFCENDLITWDELKAVELDKSAKNEKDAPFERNFIKLDELLIETISALECLSHYTLSQTQAQQVMKGNTVLLYHHDVPLDEDEVCVLYQDQLLAIGALEKNQFKPKRLFTI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: TMIG1_MOUSE
Sequence: MVWKITGPLQACQLLLVVLSLPQGRTSSVLTVNGRTENYILDTQHGVQASLECAVQNHTEDEELLWYREDGIVDLKNGNKINISSVCVSPINESDNGVRFTCKLQRDQTVSVTVVLNVTFPPLLSGNGFQTVEENSDVSLVCNVKSNPQAQMMWYKNNSALVLEKGRHQIHQTRESFQLSITKVKKSDNGTYSCIASSSLKMETMDFHLLVKDKVFVMPAEPIIAACVVVVLTMAFALFSRRKRIMKLCGKKNDPNSETAL
What is the function of this protein?
May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.
What are the official names of this protein?
Transmembrane and immunoglobulin domain-containing protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: DEF1_SHEON
Sequence: MALLKVLRFPDERLRTQATPITEFNAELQTQIDDMFETMYQEKGIGLAATQVDYHKQLIVMDLQDEVERPKVFINPEIIASSGDFCNEEGCLSVPGIYAKVDRAEFVTVKALDRHGNEFTVEADDLFAICIQHEMDHLKGKLFVDYLSPLKRQRIKQKLEKAAKQDAK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 1, PDF 1, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LEUK_RAT
Sequence: WAQVVSQENLPNTMTMLPFTPNSESPSTSEALSTYSSIATVPVTEDPKESISPWGQTTAPASSIPLGTPELSSFFFTSAGASGNTPVPELTTSQEVSTEASLVLFPKSSGVASDPPVTITNPATSSAVASTSLETFKGTSAPPVTVTSSTMTSGPFVATTVSSETSGPPVTMATGSLGPSKETHGLSATIATSSGESSSVAGGTPVFSTKISTTSTPNPITTVPPRPGSSGMLLVSMLIALTVVLVLVALLLLWRQRQKRRTGALTLSRGGKRNGTVDAWAGPARVPDEEATTASGSGGNKSSGAPETDGSGQRPTLTTFFSRRKSRQGSVALEELKPGTGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDGAAPQSL
What is the function of this protein?
Protects cells from apoptotic signals, promoting cell survival.
What are the official names of this protein?
Leukosialin, Leukocyte sialoglycoprotein, Sialophorin, W3/13 antigen.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body. Note=The sumoylated form localizes to the PML body.
Protein: ACYP_STAA3
Sequence: MRHIHLQVFGRVQGVGFRYFTQRIAMNYNIVGTVQNVDDYVEIYAQGDDADIERFIQGVIEGASPASNVTSHQLEELELNQKLSDFRSI
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RPOA_SULNB
Sequence: MRKIKVAPFMPTEVEVNEISANRAEIVAYPFESGYAVTLAHPLRRLILGSSIGYAPISVKIEGAAHEFDNIRGMHEDVAVFIINLKNIRFKIKDGSDRVELKYSFSGYKEVTAQDLNNDQIEVVNGDLPLATLNEDAELNFTMVIAKGIGYVPSEDLRDEVAPDSIALDAFFTPVRKANYKIEPVLVEDNPNFEKITFDIETDAQIGPVEAFTNALEVMNKQLSVFNGVLDVDISTTLPKRTNDDNELKPFLAAVDALGLSARSFNSLDRAGIKFLGELVLMSENEIKNIKNLGKKSLDETNECLVEHGFGPEFELKENTRANLVKKLEQLKA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: FUCM_SALA4
Sequence: MLKTISPLISPTLLKVLAEMGHGDEIIFSDAHFPAHSLGPQVIRADGLSVSDLLRAIIPLFELDSYAPPLVMMAAVEGDTLDPSVEARYRDALSLEAPCPDIVRIDRYAFYERAQKAFAIVITGECAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSC2_RAT
Sequence: MAKPTSKDSGLKEKFKILLGLGTSRPNPRCAEGKQTEFIITAEILRELSGECGLNNRIRMIGQICDVAKTKKLEEHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIAPMVHMICLLCIRTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIITLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMENRSYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRKELQAVTWDILLDIIERLLQQLQNLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYYELVESYADQRPESSLLNLITYRAQSIHPAKDGWIQNLQLLMERFFRNECRSAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPLELEERDLAVYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYETLISHIQLHYKHGYSLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCLCDCAELDRASEKKASGPLSPPTGPPSPVPTGPAVRLGHLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCSVDQLSSALCSMLSAPKTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDKFRARSTSLNERPKSLRIARAPKQGLNNSPPVKEFKESCAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGDLQGGSASSSDPGTHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGVLDTSAPYTPGGPASLGAQAAPAARPEKPCAGAQLPAAEKANLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAGTAKPPTLPRSNTVASFSSLYQPSCQGQLHRSVSWADSAVVLEEGSPGEAHVPVEPPELEDFEAALGTDRHCQRPDAYSRSSSASSQEEKSHLEELAAGGIPIERAISSEGARPTVDLSFQPSQPLSKSSSSPELQTLQDILGDLGDKTDIGRLSPEAKVRSQSGILDGEAATWSAPGEESRITVPPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDNFKSRTAASSAEKVPGINPSFVFLQLYHSPFCGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYNDSGEDFKLGTIKGQFNFVHVIITPLDYKCNLLTLQCRKDMEGLVDTSVAKIVSDRNLSFVARQMALHANMASQVHHRRSNPTDIYPSKWIARLRHIKRLRQRIREEVHYSNPSLPLMHPPAHTKVPAQAPTEATPTYETGQRKRLISSVDDFTEFV
What is the function of this protein?
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity).  Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity).  May also play a role in microtubule-mediated protein transport (PubMed:16707451).  Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618).
What are the official names of this protein?
Tuberin, Tuberous sclerosis 2 protein homolog.
Protein: CYSC_BURCM
Sequence: MKQKKVFVVWLTGVSGAGKSTLANLLKQQLDARGLRTYLLDGDTLRNGLNQDLGFSDADRRENIRRTAEVARLMMDAGFIVIAALISPFRDARSRARARFAPGTFIEVFVDVALEVAEARDPKGLYVLARQGAIPQFTGIGSAYENPLSPEVHVRTAETSPSECIATIMQKLPLDTDVGAP
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: RNH2_SHEON
Sequence: MAVFKTLTDADIAMFSTSLVAGVDEVGRGPLVGDVVTAAVILDPNRPILGLNDSKKLTEKRREALFDEICEKALSFHVGRASPAEIDELNILHATMLAMQRAVSGLKLTPALVLVDGNRSPAFTHQGLSLASHSIIKGDGLIASISAASIIAKVTRDREMDALDAAYPQYGFAKHKGYPTKAHFEAIAEHGVFDQYRKSFKPVKALLER
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIL_XENTR
Sequence: MAFCGPRTAARLSHSTRALHYTHRGHVSQRTLNEVVIASAARTPIGSFQGSLSSLPATKLGSIAIKAAVERAGIPGDEVKEVYMGNVLQAGQGQAPSRQATLGAGLAISTPTTTINKVCASGMKSIMLAAQSLMCGHQQVMVAGGMESMSNVPYCMSRGATPYGGVKLEDIIVKDGLTDVYNKFHMGNCAENTAKKLSISREEQDSFAINSYTRSKAAWDSGLIANEIVSVTISQKGRPDIIVQEDEEYKRVDFSKFSKLKTVFQKDNGTVTAANASTLNDGAAALVLMTAGAASRLNVTPLARIVAFADAAVDPIDFPIAPAYAVPKLLSEAGLKKEDIAMWEINEAFSVVVLANVKMLDIDPARVNVNGGAVSLGHPIGMSGARIVGHMAHVLKKGQFGIAGICNGGGGASAVLIEKL
What is the function of this protein?
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA.  Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms.  The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA.  Thereby, it plays a major role in ketone body metabolism.
What are the official names of this protein?
Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KAD_LACLM
Sequence: MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKASGFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNILVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLYQRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGALB_TALEM
Sequence: MLHRATTTAAAAAAAALLLCPVQALVRPDGVGKLPALGWNSWNAFGCDIDEEKILTAANQIVNLGLKDLGYEYVNIDDCWSVKSGRNATTGRIMPDLTKFPDGISGLAEKIHNLGLKIGIYSSAGWTTCAGYPASLGNETIDAETFAEWGIDYLKYDNCGVPPDWQDQYSYCVPDSGDPATNPNGTCPNLQNPAPAVYDWRTSKTAERYRRMRDALLGVQDKRTILFSLCDWGQADVNEWGAETGNSWRMSGDISPNWPRISTIANLNSFELNSVDFWGHNDPDMLEVGNGNLTLAENRAHFALWAAMKSPLIIGTALDKIDQDHLSILSNKYLLTFHQDPQIGRPAYPYKWGYNPDWTFDPGHPAEYWSGPTSSGDVLVLMLNTESGPANRTAVWSEVPELKGRNNNNNSSSTGFQVTDAWTGSSLGCVQGGYSVELESHDVAVLVVSGEC
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase B, Melibiase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPI_PIPCE
Sequence: MNVLPCSINTLKGLYDISGVEVGQHLYWQIGGFQVHGQVLITSWVVIAILLGSVTIAVRNPQTIPTNSQNFFEYVLEFIRDLSKTQIGEDYGPWVPFIGTMFLFIFVSNWSGALFPWKIIQLPHGELAAPTNDINTTVALALPTSVAYFYAGLTKKGLGYFSKYIQPTPILLPINVLEDFTKPLSLSFRLFGNILADELVVVVLVSLVPSVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ISPE_CHRSD
Sequence: MQRLSLPAPAKLNRMLHIVGRRADGYHELQTLFQFLDRSDTLHFSPRADGAIHLAPAIADVDHDANLIVRAARLLQHASGTHQGVDIHLDKRLPMGGGLGGGSSDAATTLLALDRLWSLDLGLPRLAELGLTLGADVPVFVRGHSAWAEGIGERLTPVTLDTPWFVVIHPGEEIATPAVFGHPELTRDTPPISMARALRGGAEQGRAWRNDCEAVVRRLSPDVAHALDWLSAFGPAMLTGTGSCLFCPLTSERQADRILRRVGSHWHAFKARGCNTSPLHDALGIHDEWSPMSQYGDA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PDXH_BDEBA
Sequence: MFDINKDPFEHFDRLMKEAVAKQIPEANAMSVATVDEKGVPSVRIVYLKEVSQGGFVFYGNYNSHKGKDIETNPIVCLNFHWPAIWQQIRITGKAEKISAAESDAYFATRARLSQIGAWASHQSETIPALDWLSRRVQEYEKQFDGQVVPRPPHWGGWRVIPTEIEFWFGLGGRLHERHIYQRTEDGGWKTFLRSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: TMCAL_CLOK5
Sequence: MKITGIIVEYNPFHNGHKYHIKKTRSLTNCEGIIAVISGNFVQRGAPSIVDKWNKTKMALLNGVDLVLELPALYSLSSAEFFAYGAVSLLENLGVVKNLCFGSECEDIKLLTLMGKILYEEPEELKLTLKERLHQGMSYASARGNALKEFLCHRYSLKNNSITEMLHLPNNILAIEYCKSLARLKSTINPVSIKRIGNSYNSTYINNRFSSATSIRNFLKENNSLQELEKALPYNILCILKDLSHSNYRFTFEDSLLPYLKYKNLFYGKNIKYLPDVSEGLENRIESALKNASSYDQIINYAKTKRYAYSRISRILCQFFLGFENLDTKVLRKNRCPYARVLGFNNKGMEILKKIKQNSSIPVYTKLPKNANDMLKLDLMATKGYSLLNKNIAFNQDYISSPLIIDKI
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSZ_ECO5E
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBA2_STEMC
Sequence: MLTADDKKLILQIWEKVLGHQEDFGAEALERMFITYPQTKTYFPHFDLQHGSDQIRSHGKKVVTALGNAVKSLDNLSQALSELSNLHAYNLRVDPVNFKLLSQCFQVVLAVHLGKDYTPEVHAAFDKFLSAVAAVLSEKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-2, Alpha-2-globin, Hb 2, Hemoglobin alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ISCR_SALPB
Sequence: MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDAGSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRASGRAQDAIDVKLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.
Protein: MD2L2_MOUSE
Sequence: MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSINSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKNS
What is the function of this protein?
Adapter protein able to interact with different proteins and involved in different biological processes.  Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis.  Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions.  Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs).  During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection.  Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.  May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1.  Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle.  Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
What are the official names of this protein?
Mitotic spindle assembly checkpoint protein MAD2B, Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Chromosome. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.
Protein: RF3_PSEA7
Sequence: MTTQAAEVAKRRTFAIISHPDAGKTTITEKLLLMGKAIAVAGTVKSRKSDRHATSDWMEMEKQRGISITTSVMQFPYREHMINLLDTPGHEDFSEDTYRTLTAVDSALMVLDGGKGVEPRTIALMEVCRLRDTPIVSFINKLDRDIRDPIELLDEIEAVLKIKAAPITWPIGCYKDFKGVYHLADDKIIVYVPGHGHERIETKIIDKLDSDEARAHLGDLYDNFVEQLELVQGACHTFDKDAFLKGEMTPVFFGTALGNFGVDQVLDCIVDWAPQPLSRATHERNVEPTEEKFSGFVFKIQANMDPKHRDRIAFMRICSGKYEKGMKMRHVRLGKDVKIADALTFFSSEREQLEEAYAGDIIGLHNHGTIQIGDTFSEGENFGFTGIPHFAPELFRRVRLKDPLKSKQLRQGLQELAEEGATQVFFPERNNDIILGAVGVLQFDVVASRLKEEYKVECAYEAINVWSARWIECDDEKKLKEFQDKAFENLSVDGGGHLTYLAPTRVNLSLMEERWPDIRFRATREHH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.