PharMolix/UniProtQA huggingface dataset:
Protein: NTRK2_MOUSE
Sequence: MSPWLKWHGPAMARLWGLCLLVLGFWRASLACPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQNLAKASPVYLDILG
What is the function of this protein?
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.  Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4.  Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2.  Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation.  Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades.  Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth.  Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival.  Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity.  Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation.  PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.  Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions.  Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
What are the official names of this protein?
BDNF/NT-3 growth factors receptor, GP145-TrkB/GP95-TrkB, Trk-B, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Postsynaptic density. Note=Internalized to endosomes upon ligand-binding.
Protein: PPN1_ASHGO
Sequence: MAAEEGRRLQMKNGEGVGRSGRPRWALWIAALMAGALWWTVHSDAVALMSKACGKDAATTPRAARALRGRFLHITDIHPDPLYVEGSSIAGACHGDPARDASDRAGRFGDAMGGCDAPMDLMNYTLAWVATHLRDEIDFVVWTGDNARHDNDRRQPRTAEQILHMNAQVADQFYELFQQQRDGDTMQGVPVVPSLGNNDVFPHNMFSLGPTLMTRQLQRIWAKFIPEEQRQAFEHDTSFFVEVIPDRLAVISFNTLYFFKSNPLVDNCNDKAQPGHALLLWLGSVLEEMRARNMKVWLSGHVPPIPKNFEGSCYNKLAWWTYEYRDVIIGGLYGHMNVDHFYPADGKAAKKSIKRRGKARTKERNTQEQPLDILDDSVDNLFSGRGAMPLRKEKYMRRLFKDVYCPIAKRLEDKGKQEQSYERYSMVHVAASVIPTFNPGFRVWEYNLTGIDNAVAPAPWTRLVRRAQQILSPLRKKKHGPDRTLPPKKPKHLAAGPGHIPQALTPIRFTQYYADLAEINKDYARELEAGRSHDEAAAAAFRYKIEYTSEDEPYPMESLLVRDYVKLASKLTEDRTAWKTYVRRAFVSSGYRDN
What is the function of this protein?
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
What are the official names of this protein?
Endopolyphosphatase.
What is the protein family that this protein belongs to?
Belongs to the endopolyphosphatase PPN1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein.
Protein: MUTL_NITWN
Sequence: MPVRQLPETVVNRIAAGEVVERPASVVKELVENAIDAGATRIDVFTDGGGRRRIGVTDDGAGMAKGDLALAVDRHATSKLDDEDLLGIRTLGFRGEALPSIGAVARLCITTREAREPHAWSLTVEGGRKSEIIPAALTNGTRVEVGDLFYATPARLKFLKTDRTEAEAIREVVRRLAMARPDIGFTLAGEERAPVTWTAALPGAAGRLTRLGDILGGDFRAAAIPVRAEREGVIVEGFAAAPSLTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVAALFVTADPREVDANVHPAKTEVRFRNAGLVRALIVHALKEGLAREGRRTAANRDGAVLTAFRPAPSPRPANWDWRESPAAPADARPWIGGPPAAAFAEAGQAALDVGAPSADVRFDAHPPLDLVDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKTALARDGVQRQILLIPDIVELDEATVEKLIDRATELEKFGLAIESFGPGAVAVRETPSLLGKINAAALLRDLAEHMTEWEETLPLERRLMHVAATMACHGSVRAGRILKPEEMNALLREMEATPNSGQCNHGRPTYVELKLDDIEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: FOLD_PROMP
Sequence: MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRVGIKSYIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVDGLNEQNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMMLNLNATVTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTSSDKSKTRLCGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL5_AERPE
Sequence: MSAKAQSLPIPPERVSEILDEWKRSPMRRPRIVKVTVNISIGQSGERLQRAAEVLEELTGQKPVFRKAKRTIRAFGVRKGENIAVMVTLRGEKALNFLKRALDAVGHRIKTSSIDEHGNVSFGIEEHILIPGVKYDPRVGILGMDVAITIQRPGHRIVERRRQRRGHIPRRHRVTREETMVLLNQLFGVTFV
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL15_LISMO
Sequence: MKLHELKPSEGSRKERNRVGRGTGSGNGKTSGRGHKGQKARSGGGVRLGFEGGQLPLFRRIPKRGFTNINRKEFAIVNLDVLNRFEDGTEVTPELLVETGIIRNEKSGIKILSNGNIEKKLTVKANKFSAAAKEAIEAAGGKTEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RNM5_MYCCT
Sequence: MSKIKQIIIVEGKTDSDKLKRIYGNDLKTIQTKGLSINKKTLEMIKEFNNKTGVIIFTDPDGAGKKIRQTIIDYLDNKVLNAFIKKDDISKTSKKVGIAEASDDAIKKALDNLIIYDKNNVSLSWTDYINNNFYLKSNRIVICKYFNFDNNISSKTLFKWLNWMNVSIDDIKKIIGEYES
What is the function of this protein?
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor.  Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
What are the official names of this protein?
Ribonuclease M5, ORF L3, RNase M5, Ribosomal RNA terminal maturase M5.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease M5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECE_STRLI
Sequence: MTDAVGSIDMPDAQDEAPDSKKSRKGGKRGKKGPLKRLALFYRQIVADVRKVVWPSRNQLTTYTTVVIIFVVIMIGLVTLIDYGFSHAAKYVFG
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CMR5_SACS2
Sequence: MTEVQEEKDYKLAIEAFNLVYNALDKKAREKFRSRARDMVEEIYTSGFIPTLFYIISKAGLENNNDKLTALLNSPSSKSIDLGSSDEASYMAYLFVILYYLSERNIINKEFLINKLKNNRLELIDKLYELSPIISARIKRYLMAIKRLAEALIEVR
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).  The CMR complex degrades RNA complementary to the crRNA (target RNA) within UA dinucleotides, generating 3'-OH and 5'-phosphate ends.  Activity is dependent on the 8 nt long 5' tag in the crRNA, an unpaired 3' flag on the target RNA, and is stimulated by ATP.  Some cleavage of the guide crRNA can also be observed.
What are the official names of this protein?
CRISPR system CMR subunit Cmr5, CRISPR type III-B/RAMP module-associated protein Cmr5.
What is the protein family that this protein belongs to?
Belongs to the CRISPR system Cmr5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_BUCSC
Sequence: MNRYQTLQKKLVPFKKGCFIPFIILGDPSIEMSLKIIDVLIENGADGLELGFPFSDPLSDGKTIQKAHLRAFSSKMNIYLCFEMLQKIRKKYNTIPIGLLLYANLIFKFGINNFYLKCFNVGIDSVLIADLPVEESNDFRKCAIANNISSVFVCPHDAKKNVIKKISLYSTGYIYLLSRSGVTGTDKKIIVPSLNLIKNLKKITEKLLIQGFGISNSKQIQKIILSGISGVICGSVIIKLIENHFQNEKKMLKNIKRLSRSLKQSTIIF
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PA2H2_BOTMA
Sequence: NLWQLGKMILLETGKIPAKSYGAYGCNCGVLGRCCYVHKXXXXKLTGCDPKXXXYSYSWKXXTIVCGENNSCLKELCECDKAVAICLRENLDTYNKXXXYNYLKPF
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity (PubMed:28390830).  Shows high myotoxin activities (By similarity).  Also shows neurotoxicity, since it induces muscle paralysis when tested on mouse phrenic-diaphragm preparations (By similarity).  Displays edema-inducing activities (By similarity).  Also displays antimicrobial activity against E. coli and C. albicans, as well as antitumoral activity against some human and mice cell lines (By similarity).  In addition, it is effective as parasiticidal agent against Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes (PubMed:28390830).  It also disrupts negatively charged liposomes in a dose- and temperature-dependent manner and shows toxicity by intraperitoneal route (By similarity).  In contrast to other phospholipase A2-like toxins, this myotoxin does not require fatty acid binding to be active (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is usually (but not here) activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog BmajPLA2-II, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y782_NITEC
Sequence: MAISDWPEAERPREKLIQKGATVLSDAELLAIFLRTGITGKSAVELARNLLTHFGSLTKLCAANLHEFSKLPGMGPAKFAQLQAVMEMARRALAEELKSGDIMDSPQSVRSYLRLSLGGKPHEVFVGIFLDARHRTIMIEELFRGTLTQASVYPREVVKRALYHNAAAMIFAHNHPSGVAEPSRADEMLTQSLKQALALVDVKVLDHFVIGNNETVSFAERGLI
What are the official names of this protein?
UPF0758 protein Neut_0782.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: PSAA_PROMA
Sequence: MTISPPERGEKAKGAAPTPYDQPVDRDHAPIDYEKLNKPGFWSSKLSKGPKTTTWIWNLHADAHDFDTHLGDLEETSRKIFSAHFGHLAVVFIWMSAAFFHGARFSNYTGWLADPTNVKPGAQVVWPVVGQEILNADLGGNYQGLQITSGIFQMWRAWGITSEVQLMALAIGGVIMAALMLHGGIYHYHKAAPKLEWFRKIEPMLQHHQIALIGLGSIAWAGHLIHIGAPVAALLDAIDAGNPLVVDGVSIASAADVTNLAPRLCDPAVASQIFPSLAGRTVENFFTLNWWAFTDILTNKGGLNPVTGSLWMTDISHHHLAFGVFAIFGGHMWRNNVHGVGHSMKEIMDVHKGDPILFPAPKGHQGIFEFLSNSWHGQLSINLAMVGSASIVVAHHMYALPPYPYIAIDYPTVLGLFTHHMWIGGLFICGAAAHAGIAMIRDYDPAVHIDNVLDRILKARDAIISHLNWVCMWLGFHSFGLYIHNDVMRALGRPKDMFSDTGIQLQPFLAQWVQNLQQSAVGTGDLVGAGNLPGSVLSEVFNGNVVEVGGKVAIAPIPLGTADLMIHHVHAFTIHVTLLILLKGVLYARSSRLIPDKAQLGFRFPCDGPGRGGTCQVSSWDHVFLGLFWMYNSLSVVIFHFSWKMQSDVWGLTGGNFAQSSITINGWLRDFLWAQSSQVLTSYGQPISMYGLMFLGAHFVWAFSLMFLFSGRGYWQELFESIIWAHNKLKVAPTIQPRALSITQGRAVGVAHFLLGGIATTWAFFHARLIGLG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: GVPE2_HALSA
Sequence: MDDLLAELKSEMDAAGVDADVEFSLPTLELTAALDATIDDTSQLYTDDPPHHYTDTPLTGDDLPLLEAWLDDAQLHGVGDDIIAEYIDEVLLVLITVRGGACGKELLQDVRRLFGADVSPGTMYPHLKQLADAGLLEMSELTKRKVYRVADAQAAIEHVDSVVLQLLTFAVGLQTIMADCIVNQSADPQPQDE
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpE 2.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: MNME_VIBC1
Sequence: MTTDTIVAQATAPGRGGVGIIRVSGPKANQVALEVTGKTLKPRYAEYLPFQAEDGTVLDQGIALYFPNPHSFTGEDVLELQGHGGPVVMDMLIKRILGIDGVRAARPGEFSERAFLNDKMDLTQAEAIADLIDASSEEAAKSALQSLQGQFSQRIQTLVESLIHLRIYVEAAIDFPEEEIDFLADGKVSGDLQAIIDNLDAVRKEANQGAIMREGMKVVIAGRPNAGKSSLLNALSGKESAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVEKIGIERAWDEIAQADRVLFMVDGTTTDATDPKDIWPDFVDRLPNSIGMTVIRNKADQTGEEMGICHVNDPTLIRLSAKTGAGVDALRTHLKECMGFSGNTEGGFMARRRHLDALERAAQHLQIGQEQLEGYMAGEILAEELRITQQHLNEITGEFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFM_CHICK
Sequence: MSYTMEPLGNPSYRRVMTETRATYSRASASPSSGFRSQSWSRGSGSTVSSSYKRTNLGAPRTAYGSTVLSSAESLDVSQSSLLNGAAELKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAELAALRQKHAGRAQLGDAYEQELRELRGALEQVSHEKAQIQLDSEHIEEDIQRLRERFEDEARLRDETEATIAALRKEMEEASLMRAELDKKVQSLQDEVAFLRGNHEEEVAELLAQLQASHATVERKDYLKTDLTTALKEIRAQLECQSDHNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNNDLTTYQDTIHQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSAFSGSITGPIFTHRQPSVTIASTKIQKTKIEPPKLKVQHKFVEEIIEETKVEDEKSEMEDALSAIAEEMAAKAQEEEQEEEKAEEEAVEEEAVSEKAAEQAAEEEEKEEEEAEEEEAAKSDAAEEGGSKKEEIEEKEEGEEAEEEEAEAKGKAEEAGAKVEKVKSPPAKSPPKSPPKSPVTEQAKAVQKAAAEVGKDQKAEKAAEKAAKEEKAASPEKPATPKVTSPEKPATPEKPPTPEKAITPEKVRSPEKPTTPEKVVSPEKPASPEKPRTPEKPASPEKPATPEKPRTPEKPATPEKPRSPEKPSSPLKDEKAVVEESITVTKVTKVTAEVEVSKEARKEDIAVNGEVEEKKDEAKEKEAEEEEKGVVTNGLDVSPVDEKGEKVVVTKKAEKITSEGGDSTTTYITKSVTVTQKVEEHEESFEEKLVSTKKVEKVTSHAVVKEIKE
What is the function of this protein?
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.  May additionally cooperate with other neuronal intermediate filament proteins to form neuronal filamentous networks (By similarity).
What are the official names of this protein?
Neurofilament medium polypeptide, NF-M, 160 kDa neurofilament protein, Neurofilament triplet M protein.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon.
Protein: CCMC_ECOL6
Sequence: MWKTLHQLAIPPRLYQICGWFIPWLAIASVVVLTVGWIWGFGFAPADYQQGNSYRIIYLHVPAAIWSMGIYASMAVAAFIGLVWQMKMANLAVAAMAPIGAVFTFIALVTGSAWGKPMWGTWWVWDARLTSELVLLFLYVGVIALWHAFDDRRLAGRAAGILVLIGVVNLPIIHYSVEWWNTLHQGSTRMQQSIDPAMRSPLRWSIFGFLLLSATLTLMRMRNLILLMEKRRPWVSELILKRGRK
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein C, Cytochrome c-type biogenesis protein CcmC.
What is the protein family that this protein belongs to?
Belongs to the CcmC/CycZ/HelC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LLDD_ECO5E
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPTALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PLGF_BOVIN
Sequence: MPTVRLFTCFLQLLTGLVLPAVPTTQWALSPGNISSEVEVVPFQQVWSRSYCRPVERLVDIVSEYPSEMEHLFSPSCVSLMRCTGCCSDESMHCVPLETANVTMQLMKYRSLDQPFFVEMSFSQHVRCECKPLWEKMKQTRCGDTISQR
What is the function of this protein?
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration.  It binds to the receptor FLT1/VEGFR-1.  Also promotes cell tumor growth (By similarity).
What are the official names of this protein?
Placenta growth factor, PlGF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGC_MYCBP
Sequence: MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERG3_MYCTU
Sequence: MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
What are the official names of this protein?
C-5 sterol desaturase, Sterol-C5-desaturase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK6_GRATL
Sequence: MSRIGKKPINLPQNINITIIENNVQIQGPKGELSYKIPKLIQIKQDTKNNKLFLYKTEDNKEAQKLHGLCRTLINNMIIGVSQGFEKKLQIQGVGYRSQLDGDNLLLNVGYSHTVIVKPPKNIILEVENNTSITIKGIQKEQVGEIAAQIRRIRPPEPYKGKGIRYLNETINLKVGKSGK
What is the function of this protein?
Binds 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L6, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CSHA_GEOKA
Sequence: MTTFQELGLSQEVMKAIERMGFEETTPIQAKTIPLSLQNKDVIGQAQTGTGKTAAFGIPIVEKVNVKNSAVQALVVAPTRELAIQVSEELYKIGAVKRVRVLPIYGGQDIERQIRALKKHPHVIVGTPGRIIDHINRGTLRLEHVHTVVLDEADEMLNMGFIEDIEAILSHVPAERQTLLFSATMPDPIRRIAERFMNEPELVKVKAKEMTVPNIQQYYLEVHEKKKFDILTRLLDIQAPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLSQAKRLSVLRKFKEGAIEILVATDVAARGLDISGVTHVYNFDIPQDPESYVHRIGRTGRAGKTGVAMTFVTPREIGQLHHIERTTKRKMERMKPPTLDEALEGQQRIAIEKLLNVVETENLSFYKRAAEELLEEHDSVTIVAACLKMLTREPDTTPVQLTEEPPLAVKREKKRGGRPDGSARSRTKKRRITAH
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSP38_CAEEL
Sequence: MAQSVPPGDIQTQPGTKIVFNAPYDDKHTDHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVFDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNP
What is the function of this protein?
Central component in molecular interactions underlying sperm crawling.  Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
What are the official names of this protein?
Major sperm protein 38, MSP.
What are the subcellular locations of this protein?
Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Protein: RS14_HISS2
Sequence: MAKQSMIARDVKRAKLADKFYEKREELKKVISDVNTSDEERWAAVLKLQTLPRDSSPVRQRNRCRQTGRPHGVLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.