PharMolix/UniProtQA huggingface dataset:
Protein: SPRC_NEOVI
Sequence: DKYIALGEWAGCFGIKEKDIDKDLVI
What is the function of this protein?
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines.  Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes.  There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
What are the official names of this protein?
SPARC, Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine.
What is the protein family that this protein belongs to?
Belongs to the SPARC family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.
Protein: Y8826_DICDI
Sequence: MSSKRRNKNNKNNNKNNNKNNDNNNNIEQQDDIEDISSGDIDTTNLIIDEIEDVYDDYDNEQIKNSLNHSFSNKNNTSLNNSINLSMSLIEVEETELDISSTIRPWELNIFGSLGSSGGGISSTPISQLSPFKTPSPPSSSSSSSQSPLRKPRPSFLDSFRSQFNITNINNKNNNNNNNTTSNFNTSNILNTSNFRNTNIGINNSANNNRNISRNSLPVTFSQITPIKPKNNKQIDSQSQIKPQSQSQSQSQTQSQIQEVQFSQSESQSQTQTQSQNEEKIGFRLPSPLSPIKNIESEQKKASTTSMSYESIEKSQELQNQTQINKSKQDLTNISQKINITTSQHDKDDLGEYRMSEKGGGDDGDDDDDYDNQDEKDNNYNKTNKKQQQQHHHKGKEESQSEYYEKEKEKEKEDIATTRATTTTKSTDNSNNNINKNKEFNENDLQPWLLDALLTQTAPDYPIIQIIKHYDRKEDINMDGIRRKEYQDGSSFLVSDGVNFMIAILPTSVARDLIVSEGTRKIYHEMVGFIIEVQRYVLFPNSKYSGFELFIGNAKFIDKTNEPINFHNLKGVISSSTKLKEVIKRMSHENYWTASSPTEYSNKFFPQNVSNSHHYQITQHETIISQDQLDSLNNLSDWEKHEQPNKLYQFNIYKTNFRHKNKLKQQQQQQEQQEKENQQQQQQKQQQQQQEEQLKEQQEEQQQNQQEEEKQQPSQRQSQQNQQSQQNQQSQQNQQSQQTQQVSQKHQHSQGSQQNQQSQLLQKHQQSQGSQQRQQSQEKQQSQEKQQSQEKQQSQEKHQSQEKHQSQQSQEKQQSQKKQQSQQSQASQQKYQQSQGSQEKQQSQEKQQQQQQQISSQQKGLPKINDDEEYDDTILESFENYSQSQSDLSQQFLSQSQSQSQSQSQRQSKKRKEREENQDSENLDDTVDMNYNQIPSTLDHSTLQGHKFSMYDNTSYYSNQEQEEREIERRRRELAGEDSDEEFEILDEDQVGIGLTHDNDNDNDDEENSYTPTGAATISFLDQNIISGNSGVDESKIPKVFNKNNFDTIKEEEDDEEEKEQQNNNNNINSNSKNNNVNNKLNSQEYDDTFKDTAWIPKKSGKDKFDQSSSSTNFYSSNKKNVPQPTKSVNKPRSTALKKGASQNRQKQSEQQQQQPQQQPQLPQQQQQQQQQQQLRQQQNENTISSLNASRPITKSAPLKYIKRDLTFEEIVKRNKLIRKSREEKMEMWKQHNNIIDD
What are the official names of this protein?
Uncharacterized protein DDB_G0290301.
Protein: UVRC_PSET1
Sequence: MSEFDHVQFLKTLSSEPGVYCMLDSDNQVIYVGKAKHLKKRVSSYFRSNITDSKTRVLVSNICNVEVTLTNTETEALLLENNLIKKYQPRYNILLRDDKSYPYILLTNHKHPRLAFHRGSRKVKGEYFGPFPSAGAVSESLRLMQKIFPIRQCEDVYYRARSRPCLQYQLKRCSAPCVNKVSDEDYTEQVDYVRKFLTGKSHEVIADLIKKMEAASQQLNFELAAKVRDQIMLLRKMQEQQSISGNFAEMDVVGFAHLNGLNGIHLLMIRDHKVLGSKTYFPKVPKDSSEQEILTSFLGQYYLAPGATGRIAKEIILPFEIQESDVLGQALTQISERKVTLKVVTRGERAQYLQLANKNALNSITVKQSTQDSINKRYAQLKATLRLDDITRMECFDISHTMGENTVASCVVFDSQGPNTKEYRRYNVTGITGGDDYAAMEFALNKRYNKLVDEDKIPDVIFIDGGKGQLGRAEQYFATWPHAKMPLLVGVAKGTSRKPGLETLLIDGGRKTIPMDSDAPALHLIQHIRDESHRFAIAGHRNKRQKQRTQSLLEEINGVGAKRRQTLLKYLGGMQGVKAANIEQLKKVPGISPDMADKIFNHLHDKG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC1_PAUCH
Sequence: MTNNSGNNSGNSNNPRTENHFDYVRITLASPERIMEWGQRTLPNGQIVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYTVLSPGDNSNLFYQQLLTEDEWLEIEDETYAEDSKIISEPIVGIGAEALKYLLKELDLPFIGDGLRQEITGSKGQRRAKLIKRLRVIDNFIATGAKPEWMVLDVVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLGRLKEILAPEIIIRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPRLKIHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQRADDEVMQVLQEVIEGHPILLNRAPTLHRLGIQAFEPKLVDGRAIQLHPLVCPAFNADFDGDQMAVHVPLSIEAQTEARILMLASANILSPATGEPVITPSQDMVLGIYYLTSSKPAQTQPAFGERGLTFANTYDVISAYDNDRIGLHTWIWVRFSGEVEDDDESEMPIKIETAEDGSYTELWRYRRERFDKDKALVSRYLLTTVGRVIMNTSIMNSINAN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta', RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, organellar chromatophore.
Protein: CX6B1_ARATH
Sequence: MADAVNAQTPSLSEQYHLEKEVKQDTSAKPVEVKEVAPEVTTQAEEVKTEQAKEESPVEEAVSVVEEKSESAPESTEVASEAPAAAEDNAEETPAAAEENNDENASEEVAEETPDEIKLETAPADFRFPTTNQTRHCFTRYVEYHRCVAAKGDDAPECDKFAKFYRSLCPSEWVDRWNEQRENGTFPGPLP
What is the function of this protein?
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.  This protein may be one of the heme-binding subunits of the oxidase.
What are the official names of this protein?
Cytochrome c oxidase subunit 6b-1, AtCOX6b-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6B (TC 3.D.4.8) family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RSMA_KLEP7
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHSTMPYPVKEIRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTELGIDPAMRAENISVAQYCLMANWLSDNLPTKES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_NITOC
Sequence: MKQRLIIYAQLMRLDRPVGIFLLLWPTLWALWIAGAGQPDPKVLLVFVAGVALMRSAGCVINDFADRAFDPHVKRTINRPLATGKASSQEALLLFAGLCLVAFGLVLLLNPLTIGLSFAGALLAATYPFMKRYTHWPQAYLGAAFGWAVPMAFAAQTGTVPIAAWLLFIATVLWATVYDTFYGMVDREDDLLIGVKSTAILFGEGDRLVTALLQGALLLLLFWIGYREGLGFYYYLGLAIAAGFAGYQQYLLRSREPAQYFRAFLNNNAFGAVIFGGIALHYLTA
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRS46_HUMAN
Sequence: MACGPGDLQSLTSPLSSARLDYQPSIEGPWLRACGQTNVSCRVVKGKLVEVGKWPWQVSILFLGTYICSGSLIHHQWVLTAAHCLQRFKDLSLYSVMVGVHQRPENSTQLPLTRMVIHKDFSNLMSQDIALLKLRDSISWSPFVQPVCLPNIKFKPSIGSMCWVIGWGTTGKKG
What are the official names of this protein?
Putative serine protease 46, Serine protease 46 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: PSNA_DICDI
Sequence: MKENEDEINKTDEKYKIKNPSNNGNNKNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNSNLENIEGLNKYNIYKKKKGKNESNTSLNNIYISSPNLSERSDNSIGSYCTNKTMKSENSIINIETLFRDSVSEQNSDECGSKVDKDLDEDDDDDDDETEVPELVDYSEMIVSILYPVCITMVIVVLAIRAISSSTSKNSQIVEISNDNSGGNGDSSSGADKMVFDSVVNSLIFLAVIILSTTIMVVLYKFKLMKALYAWLMGTSILLLGVFGGFLFLILLAYLNLGLDYVTFVIVVWNFSVGGIVCIFWYSPKLLNQGYLISISVLMALFFSRLPDWTTWGILSIVSIYDIFAVLCPGGPLRILIETAQKRNENIPAMIYNASIYIGMIYNEDNLENNNNNNNNNNIELNINEVDIENNNNNEDENKNNTEDGNNNNNKNKNNNNNNNNRIENENGAENSSENGSITPPPTIPNFIKDEKEINRSSGSNGFPNFKKCANDNILIGDAETNDEIVSNAESSIDSTISESYVKPKQSIRLGLGDFVFYSVLIGKAASYQITTVFTVFIAIITGLFLTLILLAVFRRALPALPMSIIFGIIVFFLTFKILIQYIYFLGENQIFV
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.  Requires the other members of the gamma-secretase complex to have a protease activity (By similarity).
What are the official names of this protein?
Presenilin-A, PS-A.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: NMO_STAHJ
Sequence: MWYNNQLTQSLNIQYPIIQAGMAGSTTAELVATVSNKGGLGCIGAGYFTTKKLEQEIQKVQGLTSQPFGVNLFVPSHQSYTNEQVEHMNAWLKPYRKALNLEEPVVNISEEQQFKSAIQTVIKYRVPVCCFTFGIPSKEIIEQLKGAKITLIGTATTVDEAIANEHAGMDIVVAQGSEAGGHRGSFLTTNNQREPLIGTMSLIPQIVDHVSIPVVAAGGVMDGRGILASQILGAQGVQMGTAFLTTEESGANQLVKQAVLHSKETDTIVTDVFSGKSARGINNEFVETMKQYEGNIPPYPVQNQLTNSIRKTAASTGHREWTHMWSGQSPRLATSQHVNQLMDRLVEQVKTLLTVVR
What is the function of this protein?
Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates.  Acts on propionate 3-nitronate (P3N), the presumed physiological substrate.  Probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism.
What are the official names of this protein?
Probable nitronate monooxygenase, NMO, Propionate 3-nitronate monooxygenase, P3N monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family. NMO class I subfamily.
Protein: NAC7_ARATH
Sequence: MNSFSHVPPGFRFHPTDEELVDYYLRKKVASKRIEIDFIKDIDLYKIEPWDLQELCKIGHEEQSDWYFFSHKDKKYPTGTRTNRATKAGFWKATGRDKAIYLRHSLIGMRKTLVFYKGRAPNGQKSDWIMHEYRLETDENGTPQEEGWVVCRVFKKRLAAVRRMGDYDSSPSHWYDDQLSFMASELETNGQRRILPNHHQQQQHEHQQHMPYGLNASAYALNNPNLQCKQELELHYNHLVQRNHLLDESHLSFLQLPQLESPKIQQDNSNCNSLPYGTSNIDNNSSHNANLQQSNIAHEEQLNQGNQNFSSLYMNSGNEQVMDQVTDWRVLDKFVASQLSNEEAATASASIQNNAKDTSNAEYQVDEEKDPKRASDMGEEYTASTSSSCQIDLWK
What is the function of this protein?
Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity).  Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE).  Triggers thickening of secondary walls (PubMed:16103214, PubMed:25148240).
What are the official names of this protein?
NAC domain-containing protein 7, ANAC007, Protein EMBRYO DEFECTIVE 2749, Protein VASCULAR RELATED NAC-DOMAIN 4.
What is the protein family that this protein belongs to?
Belongs to the plant vascular related NAC-domain protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM3_ECO7I
Sequence: MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDNLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDTRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: APOE_ARVNI
Sequence: MKALWAVLLATLLTGCLAEGEPEVTDQLSWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQNSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQNTEELRSRLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSERLRGRLEEVGNQARDRLEEMREHMEEVRSKMEEQTQQIRLQAEIFQARLKSWFEPLVEDMHRQLANLVEKIQSSVATNSVLSTSVPQENQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: ISPE_ECO27
Sequence: MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDDGDIRLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLSTGSGANISIDKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLTLGADVPVFVRGHAAFAEGVGEIFTPVDPPEKWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIETLLKCEFSNDCEVIARKRFREVDVVLSWLLEYAPSRLTGTGACVFAEFDTESEARQVLEQAPEWLNGFVARGVNLSPLHRAML
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ISPE_SALPB
Sequence: MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVNGVENEDNLIVRAARLLMKVASESGRLPTGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSVDELAAIGLTLGADVPVFVRGHAAFAEGVGEILTPVNPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKCEFSNDCEVIARKRFREVDAALSWLLEYAPSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: Y903_METMP
Sequence: MGLKYLAFKNRGQISLELGVLVLAVAMVAVFAGYLYIQSTLESAVKINQTANGTVGMYNSAVNRITESVGNLSNN
What are the official names of this protein?
UPF0333 protein MMP0903.
What is the protein family that this protein belongs to?
Belongs to the UPF0333 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL2_MYCBT
Sequence: MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNAHGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSIQLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PRVB2_MERAA
Sequence: AFAGILADADITAALAACKAEGTFTHGEFFTKIGLKGKSAADIKKVFGIIDQDKSDFVEEDELKLFLQNFSAGARALTDAETATFLKAGDSDGDGKIGVDEFAAMVKG
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 2.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: HFLD_PSEPF
Sequence: MSPTQEQLTALGGVFLAAVLVDRIAKTGQTNEAGLSCMLGSLLVRDPKDTLDVYGGDDINLREGYRALIGALERDPSTLQREPLRYALSMLGLERQLAKRDDMLDVIGKRLPQIQSQVEHFGPAHENVIAACGALYQDTLSTLRQRIQVHGDMRNLQQPSNASKIRALLLAGIRSARLWRQLGGHRWQLVVSRRKLLKELYPLMRSE
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ISPDF_CAMJJ
Sequence: MSEISLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNISYMKKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKADCITPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIAAMGGKIWFVEGEENARKLTFKEDLKKLDLPTPSFEIFTGNGFDVHEFGENRPLLLAGVQIHPTMGLKAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVREVGFELINIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEGMAVLSSVNLKYFDWTRL
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: GSHB_SALTI
Sequence: MIKLGIVMDPIAHINIKKDTSFAMLLEAQRRGYELHYMEMADLYLINGEARACTRTLSVEQNYDKWYEFGSEQEIKLADLDVILMRKDPPFDTEFIYATYILERAEEEGTLIVNKPQSLRDCNEKLYTAWFADLTPETLVTRNKAQLKAFWEKHGDIIMKPLDGMGGASIFRVKEGDPNIGVIAETLTELGNRYCMAQNYLPAIKDGDKRVLVVDGEPVPYCLARIPQGGETRGNLAAGGRGEPRPLSESDWEIARRVGPTLKAKGLIFVGLDIIGDRLTEINVTSPTCVREIEAEYPISITGMLMDAIEARLAK
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: YOQR_BACSU
Sequence: MKKRNQYSITVDVNGGEYNQEFVILADSLSKVGRDKIIADGVTIQFNDQILELNSNKEDSNDYYKGQTLTVKEDCLNNFWKGGTVTVEDVDIHRGILIDGVVYLEKQVVDKYFSKEEE
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YoqR.
Protein: RIR2_VACCC
Sequence: MEPILAPNPNRFVIFPIQYYDIWNMYKKAEASFWTVEEVDISKDINDWNKLTPDEKYFIKHVLAFFAASDGIVNENLAERFCTEVQITEARCFYGFQMAIENIHSEMYSLLIDTYVKDSNEKNYLFNAIETMPCVKKKADWAQKWIHDSAGYGERLIAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLLYPPSEETVRSIITDAVSIEQEFLTAALPVKLIGMNCEMMKTYIEFVADRLISELGFKKIYNVTNPFDFMENISLEGKTNFFEKRVGEYQKMGVMSQEDNHFSLDVDF
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase small chain, Ribonucleotide reductase small subunit, Ribonucleotide reductase subunit 2, RNR2.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: UPP_OENOB
Sequence: MSKFTVINHPLIQHKLRILRDKNTSTKDFRDLVNEIAMLMAYEVSRDMQLEDVEIDTPVAHATVKQLTGKKVAVVPILRAGLGMVDGVVKLIPAARIGHIGMYRDEKTLEPHEYFIKLPEDIEKREVIVVDPMLATGGSAKDAIAALKKRGAKYIKLMVLVAAPEGVKAVQAADPDVDIYAAALDDHLNQNGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MNHB2_STAAM
Sequence: MKENDVVLRTVTKLVVFILLTFGFYVFFAGHNNPGGGFIGGLIFSSAFILMFLAFNVEEVLESLPIDFRILMIIGALVSSITAIIPMFFGKPFLSQYETTWILPILGQIHVSTITLFELGILFSVVGVIVTVMLSLSGGRS
What are the official names of this protein?
Putative antiporter subunit mnhB2, Mrp complex subunit B2, Putative NADH-ubiquinone oxidoreductase subunit mnhB2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYS_ALTMD
Sequence: MLDPKCLRSDIEQTAKRLAARGFNLDVAAFSSLEEKRKTLQSRTQDLQNERNVRSKSIGKAKAQGEDIAPLLAEVGKLGDELDAAKAELSELLEEINTLTQGIPNLPHESVPEGKDEDDNVEISRWGEPRTFDFEVKDHVDVAEGLNNGLDFATASKLTGSRFVVMRGDIARLNRALAQFMLDTHTQEHGYQEMYVPYLVNADSLYGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNIARDEILDAKTLPVKMTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPEDSFDALEALTGHAEVILQKLELPYRKVLLCTGDMGFGACKTYDLEVWLPAQNTYREISSCSNMLDFQARRMQARFRNPETNKPELLHTLNGSGLAVGRTLVAILENNQQADGSVTVPKALVPYMAGQEVIKA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.