PharMolix/UniProtQA huggingface dataset:
Protein: ACTB_SHEEP
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells.  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction.  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.  Part of the ACTR1A/ACTB filament around which the dynactin complex is built.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: SYGB_PSEA8
Sequence: MSAKDFLVELGTEELPPKALNSLGEAFLSGIEKGLKAAGLSYAAARFYAAPRRLAVLVEQLAVQQPDRTVNLDGPPLQAAFDASGNPTQAALGFAKKCGVDLQQIDKSGPKLRFSQTIAGQPAAGLLPGIVEASLNELPIPKRMRWAARREEFVRPTQWLVMLFGDDVVECEILAQKAGRESRGHRFHNPDNVRISSPAAYLEDLRGAHVLADFAERRELIAKRVAELAAEQQGSAIVPPSLLDEVTALVEWPVPLVCSFEERFLEVPQEALITTMQDNQKYFCLLDANGKLLPRFITVANVESKAPENIVSGNEKVVRPRLTDAEFFFKQDKKQPLESFNERLRNVVFQAQLGTVFEKAQRVSGLAAYIAERIGGNAQNASRAGILSKCDLATEMVGEFPEMQGIAGYYYATHGGEAEDVALALNEQYMPRGAGAELPSTLTGAAVAVADKLDTLVGIFGIGMLPTGSKDPYALRRAALGVLRILIEKQLDLDLVAAVNAAVEQYGDKVKAAGLAEQVLDFVFDRLRARYEDEGVDVAVYQSVRALKPSSPLDFDQRVQAVQAFRQLPEAEALAAANKRVSNILAKSEDEVPPNVDASLLVEAAEKALGSAVANAESEVAPLAAARDYRAALARLAALREPVDTFFADVMVNVDDAAVRANRYALLAKLRGSFLGVADISLLG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCFC1_MOUSE
Sequence: MTSLGSQLHRATFLTALLLLLLLQVKGVKTLIVSASLDGDKSQKDKVSSEDQGEEEYEEHFEASSEGEQWQEIDMVQQEDTISQAITLQDHLLDLAFCFNLASIMFFL
What is the function of this protein?
Sperm protein required for fusion of sperm with the egg membrane during fertilization.
What are the official names of this protein?
Sperm-egg fusion protein LLCFC1, LLLL and CFNLAS motif-containing protein 1, MSSP-binding protein CTM-1, Sperm-oocyte fusion required protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCA_SALNS
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEY1_THEAN
Sequence: MESSNHLPNKDSDTVSVTPVEFSNYQCEINPGFNDFLKKSGFEDFGFKFNVVTILGSQSSGKSHLLNSLFNASFQTMDASKGHSQTTKGIWGSLVLSKDTSMNATVVFDSEGTDSRERGEGRLTFEHRSSLFCLALSDVVIVNIWYNSMGNLTGSNYGLLKTVVEANLELVDTNNEENYKTVLFFCVRDWSPSLSPLNVVKDYVLNNYMSSIWNEISKPARFENLGVESLFEIRVFGLSNAVTQSESFEMDVKEVKKTWNSLKPREYSRRVPSDGFFVYSKNVWKTIIEQNHLDIPTQKEMLSSYRCSEIKTMILESLTNALPELKEKDFSEYLMGLLKKVENQYFSQASRYDPVVSKKVGKELLEQVCRKFQPFFESALGDYVKKLAVESSSLLDKEFSVNSSGKELKVSNARPYTVWPNFSKKCEELQKKQTEKLSHHLSSFKVTFKSTVSFEFEFEYQPLKDHLNLLVSSEFEVLRSRHLELLKQQLDSMCNSCFALVKNNMMDRSLNEDQFWDYFDELFDETHKNCVDQLTTSYVGLVKGATRTEFEQLSLVLLLKATQSNFEELQNNLEQLLLERFDKFFNYQEFKGELIPTEWHKQSAQELNNRYKESKEDALTLLQVLKTTKTKKLPSFDANYVKKNQYFYSTLEGPVSDKYSSPLTEQFTIELTNSCSKKFMEMYKNAQVVQNAGTSVSSWRNIPPVFWLVLLVLGWNELRAAFRVLLKFYILIPLLIVSYFTFSYSANKLLGPKANEYVKPVRDKALSLLTALFAWFVRTLHMIASKSSSFKQQTKNLKMAKKGNKNRDSDDEYVGKTVTKSSHSIYKHREPMDINLIVDHDEVEAEKNNLPCWRAAYASGPARPQRHLCVICGFFANYKCRNCATRRIEAINSYYCSLRCLEVHNETNCGKAVHLAQW
What is the function of this protein?
Probable GTP-binding protein that may be involved in cell development.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RIMP_MYCBP
Sequence: MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIADGDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRARGRKVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPPAPAELELAQSSEMGLARGTEAGA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_SERP5
Sequence: MKLQLVAVGTKMPDWVQTGFMDYLHRFPKDMPFELTEIPAGKRGKNADIKRILEKEGEQMLAAVGKGNRIVTLDIPGTPWETPQLAQQLERWKQDGRNVSLLIGGPEGLAPACKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PROM4
Sequence: MARIAGIDIPREKRVEVALTYIYGVGLTRAKSILAKAGVNPDIRVKDLDDGDVQKLRTAVESFTLEGDLRRQEGMALKRLQDIGCLRGRRHRMSLPVRGQRTRTNARTRRGSRKTVAGRKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MEDII_MICMH
Sequence: MTTYVWSYLLEYERERADILDAVQKVFASGSLILGQSVENFETEYARYHGIAHCVGVDNGTNAVKLALESVGVGRDDEVVTVSNTAAPTVLAIDEIGARPVFVDVRDEDYLMDTDLVEAAVTPRTKAIVPVHLYGQCVDMTALRELADRRGLKLVEDCAQAHGARRDGRLAGTMSDAAAFSFYPTKVLGAYGDGGAVVTNDDETARALRRLRYYGMEEVYYVTRTPGHNSRLDEVQAEILRRKLTRLDAYVAGRRAVAQRYVDGLADLQDSHGLELPVVTDGNEHVFYVYVVRHPRRDEIIKRLRDGYDISLNISYPWPVHTMTGFAHLGVASGSLPVTERLAGEIFSLPMYPSLPHDLQDRVIEAVREVITGL
What is the function of this protein?
Involved in the biosynthesis of the amino sugar dTDP-L-megosamine which is found in the macrolide antibiotic and antiparasitic megalomicin A.  Catalyzes the reversible transfer of the amino group from L-glutamate to the C-3 position of dTDP-3-keto-4,6-deoxyglucose to yield dTDP-3-amino-3,4,6-trideoxyglucose.
What are the official names of this protein?
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase.
What is the protein family that this protein belongs to?
Belongs to the degT/dnrJ/eryC1 family.
Protein: SECE_STRGR
Sequence: MTDAVGSIDMPDAEDEAPESKKKSRKGGKRGKKGPLGRLALFYRQIVAELRKVVWPTRSQLTTYTSVVIVFVVVMIGLVTVLDIGFARVVKYVFG
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GCSP_CHRVO
Sequence: MSLTELFNRHEFLARHIGPSDAERAEMLAAVGAPSIDALVDQTLPADIRLNRRLDLPSPQPEAEALAALKAVASKNVVNKSFIGLGYYPVLTPTVILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQMVIDLTGLEMANASLLDEATAAAEAMAMAGRVSKSKSTRFFVDSRVLPQTLDVMKTRAKYFGFELVQGHPEEAGNGDYFGALFQYPGEAGDLLDLTPHIAAVKAKGGVVAVAADVMALVALKSPAEMGADIALGNTQRFGVPMGFGGPHAAYFAFKDEMKRSAPGRIIGVSIDAKGKTALRMALQTREQHIRREKANSNICTSQVLLANIAGLYAVYHGAEGVRRIAARIHRLAAIFAHAVKEAGGKLVFDRFFDTVQVDAPKADAIYAAALAAGYNLRRVGKTVLGVAFHEAATESDLAKLIELFTGKPADIAALDAAALDAIPAALKRESAILTHPVFNTHHSEHEMLRYMKKLENRDLAMNHSMISLGSCTMKLNATSEMIPITWPEFANMHPFAPREQTVGYLELIEGLQKQLKAITGFDAISMQPNSGAQGEYAGLLAISRYHESRGEAHRNICLIPQSAHGTNPATAQMMNMQVVVVKCDEAGNVDVADLKAKAEQHAANLAALMITYPSTHGVFEQGIKEICEIVHAHGGQVYMDGANLNAQVGLTRPADIGADVSHMNLHKTFCIPHGGGGPGMGPIGLKAHLAPFIANHVVAPVPGAVEGQTAVSAAPFGSASILPISYMYIAMMGAEGMKQATENALLSANYLATRLSEHFPVLYTGANGRVAHECIIDLRPLKAASGVTEVDVAKRLMDYGFHAPTMSFPVPGTLMIEPTESEPKAELDRFIAAMAAIRAEIDRVQSGAWPADNNPLVNAPHSKADIAGDWDRPYSREQGLFPLPYVLENKFWPSVNRIDDVYGDRNVVCSCPSTESYM
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: SEC11_UNCRE
Sequence: MLSSLSPHLSNVRQTLTQVLNFALVLSTAFMMWKALSIYTNSSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAEVGEIVVYNVRGKDIPIVHRVVRAFGDDARDPKEGGGKKGKSASGTGKKESVAAGAVHSDSSFVSHKLLTKGDNNIADDTELYARGQDYLDRKVDLVGSVRGYIPAVGYVTIMLSEHPWLKSVLLGLMGVMVILQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: TRAY4_ECOLX
Sequence: MRRRNARGGISRTVSVYLDEDTNNRLIKAKDRSGRSKTIEVQIRLRDHLKRFPDFYNEEIFREVTEESESTFKEL
What is the function of this protein?
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell.  It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations.  Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site.  Relaxosome formation requires binding of IHF and TraY to the oriT region, which then facilitates binding of TraI.  Also positively regulates tra gene expression (By similarity).
What are the official names of this protein?
Relaxosome protein TraY.
What is the protein family that this protein belongs to?
Belongs to the TraY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_SALEP
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YRD1_CAEEL
Sequence: MTSDRNGKLKPRLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARYRFDGIRAVISFHGTLTPIEGIPLELLDDNSIQVHHGDADKHVSKVTVDAFHEEMRARNSDFVFISHGKAMHSFTDPESAGIAPSGVGYDANAEKRSWKATLEFLKEAFA
What are the official names of this protein?
Uncharacterized protein K02A2.1.
Protein: NANK_SHIB3
Sequence: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPQALRDALAALVAPLQAHAQQVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLSNLPTIAINDAQAAAWAEYQALEGDITDMVFITVSTGVGGGVVSGGKLLTGPSGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELMGADARTIFTRAGQGDEQAQQLIHRSAHVLARLIADIKATTDCQCVVVGGSVGLAEGYLALVKTYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: OPGD_SHISS
Sequence: MDRRRFIKGSMAMAAVCGTSGIASLFSQAAFAADSDIADGQTQRFDFSILQSMAHDLAQTAWRGAPRPLPDTLATMTPQAYNSIQYDAEKSLWHNVENRQLDAQFFHMGMGFRRRVRMFSVDPATHLAREIHFRPELFKYNDAGVDTKQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDSKEEFPDFTAFWFDTVKPGATTFTVYALLDSASITGAYKFTIHCEKSQVIMDVENHLYARKDIKQLGIAPMTSMFSCGTNERRMCDTIHPQIHDSDRLSMWRGNGEWICRPLNNPQKLQFNAYTDNNPKGFGLLQLDRDFSHYQDIMGWYNKRPSLWVEPRNKWGKGTIGLMEIPTTGETLDNIVCFWQPEKAVKAGDEFAFQYRLYWSAQPPVHCPLARVMATRTGMGGFPEGWAPGEHYPEKWARRFAVDFVGGDLKAAAPKGIEPVITLSSGEAKQIEILYIEPIDGYRIQFDWYPTSDSTDPVDMRMYLRCQGDAISETWLYQYFPPAPDKRQYVDDRVMS
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLMS_SALTI
Sequence: MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEANAHPHVSEHIVVVHNGIIENHEPLREALKARGYTFVSETDTEVIAHLVNWELKQGGTLRDAILRAIPQLRGAYGTVIMDTRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDNTGAEVKRQDIESNLQYDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADDLLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIELLAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFSDQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_TRICV
Sequence: MSIRLYKSYTPGTRNRALSSFTEITKTKPEKSLIQKNHRSKGRNNRGVITIRHRGGGHKRRYRIIDFGRKKHNVEGVVAAIEYDPNRNARIALLHYTDGEKRYILHPNNLNVGDRVVSGMEAELVIGNALPLEKIPLGASVHNIELIPNRGGQIVRAAGTSAKILAKEGDYVTLRLPSKEIRLIRKECFATIGEVSNNDAFLVQSGKAGRTRWLGKRPTVRGSVMNPCDHPHGGGEGRAPIGRTRPLTPWGKPALGIKTRKNKKASDAYILRRRS
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VAMP2_XENLA
Sequence: MSAPAAGPPAAAPGDGAPQGPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDTKLSELDDRADALQAGASQFETSAAKLKRKYWWKNMKMMIIMGVICAIILIIIIVYFST
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity).  Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters.  Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 2, VAMP-2, SYBII, Synaptobrevin-2.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane.
Protein: CPT2_HUMAN
Sequence: MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLGGFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS
What is the function of this protein?
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397).  Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.  Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056).
What are the official names of this protein?
Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: BLAB_BACCE
Sequence: MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTELGYFSGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFKKRVTDVIITHAHADRIGGMKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQSVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYQILAGGCLVKSASSKDLGNVADAYVNEWSTSIENVLKRYGNINLVVPGHGEVGDRGLLLHTLDLLK
What is the function of this protein?
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.  Benzylpenicillin is a better substrate than cephalosporin C and ampicillin (PubMed:3131315, PubMed:2501295).
What are the official names of this protein?
Metallo-beta-lactamase type 2, B2 metallo-beta-lactamase, Beta-lactamase II, Cephalosporinase, Metallo-beta-lactamase type II, Metallothioprotein beta-lactamase II, Penicillinase, Zinc-requiring beta-lactamase II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MYO1A_HUMAN
Sequence: MPLLEGSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWNGGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNYRKYFRSEAALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVKVVQGPAGGDNSKLRYKKKGSHCLEVTVQ
What is the function of this protein?
Involved in directing the movement of organelles along actin filaments.
What are the official names of this protein?
Unconventional myosin-Ia, Brush border myosin I, BBM-I, BBMI, Myosin I heavy chain, MIHC.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Protein: CAS2A_RHORT
Sequence: MGTRRSNAEHAYVVAYDIADPKRWRQVFKTMKGYGQWVQLSVFQCRLDGGRRIAMASILESLIDRETDHVLMLDLGPAEDVDLAVESLGKAFETLERQAMII
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: ERG6_ASHGO
Sequence: MSEQDQELRNRQAQFAKELHGESVERSGLTALLGKNREAQQEAVAKYLRHWDGATDAEAEERRLADYNESTHSYYNVVTDFYEYGWGASFHFSRFYTGESFAMSMARHEHYLAHRAGITSGDLVLDVGCGVGGPAREIARFTGCRVVGLNNNDYQIMKGKHYSRKLGLGDQVSYVKGDFMNMDFPDATFDKVYAIEATCHAPSFEGVYGEIYRVLKPGGVFAVYEWVMTENYDETNPEHRRIAYDIELGDGIPKMYSVKVARDALAKVGFEILVDEDRADNDDPVPWYYPLTGEWAYIQTIADLGTFVRTSALGRRVTSAFVSLMETLRLAPRGSSEVVNALESAAAGLVAGGKSKLFTPMMLFVARKPETAE
What is the function of this protein?
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
What are the official names of this protein?
Sterol 24-C-methyltransferase, Delta(24)-sterol C-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: Y488_BUCAI
Sequence: MKTKLREMLRFPCFFTYKIIGLAQPELIDQIIKVIQIQIPGDYTPQVKSSNRGNYLSVSITICAKNFEQIECLYHEISKINIVRMVL
What are the official names of this protein?
UPF0250 protein BU488.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.