PharMolix/UniProtQA huggingface dataset:
Protein: VP6_ROTBB
Sequence: MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDATSEIIENWNLQNRRQRTGFIFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVITSADGATTWYFNPVILRPANVEVEFLLNGQVVNTYQAKFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEFHATVGLTLRIESAVCESVLADANETMLANVTAVRQEYAIPIGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: KMO_ASPCL
Sequence: MADTVRKPQKVVIVGAGPVGSLAALYAAARGDEVEVYELRGDLRDPSTIPLNFTKSINLALSERGINAMKHSNREELTKNVLRDTIPMYGRMIHGKDRGQLWEAAQAYDVHGRAINAVDRSTLNNALLDELEHTPNVKLFFNHKLTGADFRANKAWFERRVPGEAPLPNSANRVPEIEVDFDFMLGADGAHSAVRYHMMKFARVDYQQEYIDTLWCEFRIAPTENGEFRISPNHLHIWPGREFMFIALPSADKSFTCTLFAPAVHYTYLASSPQKLLDFFDVHFPGVSPELIPPADLQEQFATNPHLPLISLKCKPHHFGSSVAIVGDAAHAVLPFYGQGLNAGLEDIRVLFEVLDKHSVYDLDASHEARREAREKAFQAYTDQRCADTHAINDLSKENYVEMRWGVKTPLYKLRKSIEEILDRYVPSLGWQTQYSRVSFSNQRYSDVIKLARRQGTVLGLGLGSTFITAVGVAGYMMWKNPKQYSPLCFMRYCLRHVSHIWVKFFRNTAYA
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Biosynthesis of nicotinic acid protein 4, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: AAPAT_CHLTE
Sequence: MSVESFERFLSRRVLSMQESQTMKITGLAKKMQAEGKDVVSLSAGEPDFPTPENVCEAGIEAIRKGFTRYTANSGIPELKKAIIRKLQRDNGLEYAEDEIIVSNGGKQALANTFLALCDEGDEVIVPAPYWVSFPEMARLAEATPVIVETSIETGYKMTPEQLAAAITPKTRILVLNSPSNPSGAVYNEAEVRALMQVIEGKEIFVLSDEMYDMICYGGVRPFSPARIPEMKPWVIVSNGTSKSYSMTGWRIGYLAAPKWIINACDKIQSQTTSNANSIAQKAAVAALDGDQSIVEQRRAEFEKRRDFMFRELNTISGIECTLPEGAFYIFPSIKGLLGKTFGGKVMKDSTDVAEYLLTEHYVATVPGDAFGAPENLRLSYAASIEELAEAVNRIRKAFS
What is the function of this protein?
Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate (PubMed:25070637).  Can also transaminate prephenate in the presence of aspartate (PubMed:25070637).
What are the official names of this protein?
Aspartate/prephenate aminotransferase, AspAT / PAT.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLPP3_BOVIN
Sequence: MQNYKYDKAIVAESKNGGSPALNNNPRKGGSKRVLLICLDLFCLFMAGLPFIIIETSTIKPYHRGFYCNDESIKYPQKTGETINDAVLTAVGIVIAILAIITGEFYRIYYLKEKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLNVCNPDFSQINCSVGYIQNYRCRGEDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPPSAIRKDMLSPVDIDRSNHHNMV
What is the function of this protein?
Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth.  Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis.
What are the official names of this protein?
Phospholipid phosphatase 3, Lipid phosphate phosphohydrolase 3, PAP2-beta, Phosphatidate phosphohydrolase type 2b, Phosphatidic acid phosphatase 2b, PAP-2b, PAP2b.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.
Protein: TGT_SHEDO
Sequence: MKFELDTTQGRARRGRLIFDRGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQDSLGSDVVMIFDECTPYPATEDEARKSMQMSLRWAQRSRDEFDRLENPNALFGIIQGGVYEDLRDESLTGLVNIGFDGYAIGGLAVGEPKPDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTAPLDEKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVSDFYTGLGREVPEVPELVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PNP_VIBPA
Sequence: MFEKPVVKTFQYGNHTVTLETGVIARQATAAVMVTMDDTAVFVSVVGKKEAVAGQDFFPLTVNYQERTYAAGKIPGGFFKREGRPSEGETLTARLIDRPIRPLFPDAFKNEVQVIATVVSVNPDVQPDIPTMIGTSAALAISGIPFNGPIGAARVGHIDGQLVLNPSQTELNASRLDLVVAGTESAVLMVESEADNLTEEEMLAAVVFGHDQQQVVINAINEFKAEVATPAWDWVAPEENTALKTKIAELAEAKLVEAYQITEKMARYDRIHEIAAEVNEALLAQDPEADTKEIHTIFHDLEKTVVRRSIIAGNPRIDGREKDMVRALDVRTGVLPRTHGSALFTRGETQALVTATLGTQRDAQIIDELTGERKDHFLLHYNFPPYCVGETGFVGSPKRREIGHGKLAKRGIAAVMPSVDEFPYTVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKASVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTSTGVTALQMDIKIEGITKEIMQIALNQAQGARKHILSVMDEALAGARDDISEFAPRIHTMKISAEKIKDVIGKGGAVIRALTEETGTTIEIEDDGTIKIAATEGAAAKEAIRRIEEITAEVEVGRIYTGKVARLADFGAFVTVLPGKDGLVHISQIAEKRVEKVSDYLTEGQEVQVKVLEIDRQGRVRLSMKEAVEKPAEEAAAEAPAAKEE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETAA1_HUMAN
Sequence: MSRRRKHDDSPSPKKTPHKTVAAEECGSVVEPGRRRLRSARGSWPCGAREGPPGPVRQREQPPTAALCSKSNPEERYETPKRALKMDSLSSSFSSPNDPDGQNDIFWDQNSPLTKQLGKGRKKQIYTTDSDEISHIVNRIAPQDEKPTTNSMLDMWIGETAIPCTPSVAKGKSRAKISCTKLKTQSQEEELMKLAKQFDKNMEELDVIQEQNKRNYDFTQMISETEILSNYKDNIQMWSLHNIVPEIDNATKKPIKGNTKISVANNQNSSQKPFDQIAEAAFNAIFDGSTQKCSGQLSQELPEAFWSTSNTTFVKTNALKEEKIITNETLVIEKLSNKTPRSLSSQVDTPIMTKSCVTSCTKEPETSNKYIDAFTTSDFEDDWENLLGSEPFAMQNIDMPELFPSKTAHVTDQKEICTFNSKTVKNTSRANTSPDARLGDSKVLQDLSSKTYDRELIDAEYRFSPNSNKSNKLSTGNKMKFENSSNKIVIQDEIQNCIVTSNLTKIKEDILTNSTEASERKSALNTRYSNEQKNKCILNQSIKAPVNTDLFGSANLGSKTSVSNPNQTSASKVGSFFDDWNDPSFANEIIKACHQLDNTWEADDVDDDLLYQACDDIERLTQQQDIRKDSKTSESICEINNNSEHGAKLTQQQDIRKDSKTSESICEINNNSEHGAKNMFAISKQGSNLVQSKHLNPGSISVQTSLTNSSQIDKPMKMEKGEMYGNSPRFLGATNLTMYSKISNCQINNLHVSYTNTDVPIQVNSSKLVLPGSSSLNVTSDHMNTEITTYKKKLSTNQPCHKTVTDEAQSNLNTTVGFSKFTFTRMKNSQILSQFNQNCITGSMSDTKITQGVEKKKGVNPLLEEAVGQQSLVKLSESLKQSSKEEEEKNRKCSPEEIQRKRQEALVRRMAKARASSVNAAPTSFL
What is the function of this protein?
Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717).  Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717).  Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717).
What are the official names of this protein?
Ewing's tumor-associated antigen 1, Ewing's tumor-associated antigen 16.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes at sites of DNA damage following replication stress (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (PubMed:27601467, PubMed:27723720).
Protein: HMGA_ASPFU
Sequence: MPVTQFSHPDPYSYQTGFDSYHETEAVKGALPVGQNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHENFKAEDADSYHTSMTTETHKLHHIPNQLRWDPFDLDETVDWVHGLHLVAGAGDPTLKHGLGIILYAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRLMVRPNEICVIPRGVRYRVTLPAGPVRGYICELYQGHYQLPELGPIGSNCLANARDFQAPVASFEDEEEPTEWRLYSKFNNTLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTIGSISFDHPDPSIFTVLTGPSDHAGTAIADFVIFPPRWLVAENTFRPPWYHRNTMSEFMGLICGNYDAKTGGGFQPAGASLHNVMSAHGPDADAFEGASNAELKPQKVGDGSMAFMFESCLMVGVSEWGLKTCQKVQEQYNEHSWRPLKRHFKNPNKA
What is the function of this protein?
Homogentisate 1,2-dioxygenase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin (PubMed:19028908, PubMed:19715768, PubMed:22046314).  The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA) (PubMed:19028908, PubMed:22046314).  The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD (PubMed:22046314).  The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate (PubMed:19028908, PubMed:19715768).  When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization (PubMed:19715768).  On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate (PubMed:19715768).  4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).
What are the official names of this protein?
Homogentisate 1,2-dioxygenase hmgA, Homogentisate oxygenase hmgA, Homogentisic acid oxidase hmgA, Homogentisicase hmgA, L-tyrosine degradation gene cluster protein hmgA, Pyomelanin biosynthesis cluster protein hmgA.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: CAV1_MOUSE
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVTEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSTIFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKIFSNIRISTQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes (By similarity).  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: MUTL_CHLTE
Sequence: MASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDNGCGMESDDVLLSVERFATSKISEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSLGTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKFLKSNATEFKHIHETVKAFVLSYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPGMMVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHPAKLEVRFEDEKSIRSMVYPVVKRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSYSSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETSLSAGSRPTPMVQESLLTPSVDQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEAAPNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEATILQDMIAEYQENAAKLKLEKRDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPYVCPHGRPVIIRLSLGELDRMFGRT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: NCAP_CVBEN
Sequence: MSFTPGKQSSSRASSGNRSGNGILKWADQSDQSRNVQTRGRRAQPKQTATSQQPSGGNVVPYYSWFSGITQFQKGKEFEFAEGQGVPIAPGVPATEAKGYWYRHNRRSFKTADGNQRQLLPRWYFYYLGTGPHAKDQYGTDIDGVYWVASNQADVNTPADILDRDPSSDEAIPTRFPPGTVLPQGYYIEGSGRSAPNSRSTSRASSRASSAGSRSRANSGNRTPTSGVTPDMADQIASLVLAKLGKDAAKPQQVTKQTAKEIRQKILNKPRQKRSPNKQCTVQQCFGKRGPNQNFGGGEMLKLGTSDPQFPILAELAPTAGAFFFGSRLELAKVQNLSGNLDEPQKDVYELRYNGAIRFDSTLSGFETIMKVLNENLNAYQQQDGTMNMSPKPQRQRGQKNGQGENDNISVAAPKSRVQQNKIRELTAEDISLLKKMDEPFTEDTSEI
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the betacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: DISA_ACIC1
Sequence: MAANDRPDRSDRGADERLRATLAAIAPGTQMRDALERILRGNTGALIVLGYDKTVESICSGGFNLDVELSAPLMRELAKMDGAIILDEKATRIIKANVHLQPDPSIPTNESGTRHRSAERTARQTGFPVISVSQSMRIIALYVDGRRHVLDEPSAILSRANQALATLERYKLRLDEVSGTLSALEIEDLVTVRDAAVVAQRLEMVRRIADEIQGYVVELGTDGRLLSLQLDELLAGVEPERDLIVRDYLPAAAGKRGRSVDDVLRDLDALTPEELLDLGTVARVIGCGGTENLDNPVSPRGYRLLAKIPRLPCAVIERLVEHFGTLQKLLAASVDDLQAVEGVGESRARSVREGLSRLAESSILERYV
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: LRK17_ARATH
Sequence: MIRGLLLGIIWMIFCVCSSFQQETPFVYNNFGHVDHLHLDGSARIIPSGGILQLTNATNSQIGHVFYEKPIEFKSSESVSFSTYFVCALLPAGDPSGHGMTFFVSHSTDFKGAEATRYFGIFNRNGSTSTRVLAVELDTSLASDVKDISDNHVGIDVNSAESITSANASYFSDKEGKKIDIKLLSGDPIQVWVDYEGTTLNVSLAPLRNKKPSRPLLSSTSINLTDILQGRRMFVGFSGSTGSSMSYQYILGWSFSKSMASLPNIDISKLPKVPHSSTKKKSTSPVLSVLLGLIAFIVLGILVVAYLYRRNLYSEVREEWEKEYGPIRYSYKSLYKATKGFNRSEFLGRGGFGEVYKGTLPRSRELREVAVKRVSHDGEHGMKQFVAEIVSMRSLKHRSLVPLLGYCRRKHELLLVSEYMPNGSLDHYLFNHDRLSLPWWRRLAILRDIASALSYLHTEADQVVIHRDIKAANVMLDAEFNGRLGDFGMSRLYDRGADPSTTAAVGTVGYMAPELTTMGASTGTDVYAFGVFLLEVTCGRRPVEPGLPEAKRFLIKWVSECWKRSSLIDARDPRLTEFSSQEVEKVLKLGLLCANLAPDSRPAMEQVVQYLNGNLALPEFWPNSPGIGVLSPMALSPAPLVIPSLSFSSSSSNNSMFITHSVLYGSGR
What is the function of this protein?
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.
What are the official names of this protein?
L-type lectin-domain containing receptor kinase I.7, LecRK-I.7.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: T150B_HUMAN
Sequence: MWGYLSLMPVFLAVWAISGVWIVFAIAVTNRTVDLSKGFPYISICGSFPPQSCIFSQVLNMGAALAAWICIVRYHQLRDWGVRRWPNQLILWTGLLCALGTSVVGNFQEKNQRPTHLAGAFLAFILGNVYFWLQLLLWRLKRLPQPGAAWIGPLRLGLCSVCTILIVAMIVLHACSLRSVSAACEWVVAMLLFALFGLLAVDFSALESCTLCVQPWPSLSPPPASPISLPVQL
What is the function of this protein?
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859).  Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859).  May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).
What are the official names of this protein?
Modulator of macroautophagy TMEM150B, Protein DRAM-3, Transmembrane protein 150B, Transmembrane protein 224.
What is the protein family that this protein belongs to?
Belongs to the DRAM/TMEM150 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859).
Protein: DPO4_STAAR
Sequence: MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMZA_NATPD
Sequence: MHVDIVPVGDLPAVVKREASSGLRSVYDCEVTIHDSQPVPDGAYDSGRDQYRAEEFIELASRVGNGEKNIAITDTDLYYRRRNYVFGLAYLSGKGSVISTHRLQTSSDGGFSEKSAGDIFADRVRKEVVHEVGHTLGLEHCDNSRCVMNFSPTVREVDVKEENLCGSCQRQIL
What is the function of this protein?
Probable zinc metalloprotease whose natural substrate is unknown.
What are the official names of this protein?
Archaemetzincin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M54 family.
Protein: YD124_YEAST
Sequence: MRIGMEELRRALALLNGQGYEFMVFIKEKDHLISESIPKNLFSESFISSSIEKNPPLTFDPLVNRKRITVYEENIQPAIMLPLDQPLLIQNYLYTAFKLLRQVPCKAIAKLWIKIIEPRKKTRFPYIKGNAGRPEWWPKDVEHKEPDHLQKADRLKLMCTIIMNVLPQSPFSLEILDELTGVTAAMTIFKKETVKKVIMKNVFEIAKCLCNKDFKQKTISLDDLNDLAQKQKKSYHSRRFDVNKMVKVEKDLLQQSSGSDSSPSMILPSKESDTEYFPREYPKDPVSEDYSNSISRLENLVEFDPLFLTKLDELTSSDDCKDFI
What are the official names of this protein?
Uncharacterized protein YDR124W.
Protein: HBA_PANHO
Sequence: MVLSAADKSNVKAAWGKVGGNAGAYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGEKVAAALTKAVGHLDDLPGTLSDLSDLHAHKLRVDPVNFKLLSHTLLVTLACHLPNDFTPAVHASLDKFLASVGTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RS2_CLOBH
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVKKVEEAYNFLRSVAEEGKDVLFVGTKKQAQEAIEEEAKRSEMHFVNNRWLGGMLTNFTTITARINKLEELDKMEEDGTFEVLPKKEVIKLKNEREKLEKNLGGIRKLDANNVGAMFIVDPRKEKNAILEAKRLGIPVVAIVDTNCDPDEVDFVIPGNDDAIRAVRLIAAKMADAVLEGRQGEQLAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ALO_DEBHA
Sequence: MRSDIPETLQNFVSTKTVHQTWAKTFFCKPQAIFQPRTVDEIRELVDQARINGKTIMTVGSGHSPSDMTMTKEWLCNLDRFNQVLKKEEFSGPTRNGEGEEVKFVDLTVQAGCRIYELNRYLKENELAIQNLGSISDQSMAGVISTGTHGSTQYHGLVSQQVVSIEIMNSAGKLITCSSMENTQLFKAAMLSLGKIGIITHVTLRTIPKYTIKSKQEIIKFDTLLKNWDTVWLDSEFIRVWWFPYSGNCVCWRASKSSEPLSKPRDSWYGTWFGRKFYESLLWISVHICPHLTPLIEKFVFKNQYGDVETLGHGDVAVQNSVEGLNMDCLFSQFVNEWSTPLSSGQDVLIKLNDVIQTAREQNRFYVHAPIEVRCSNLTYSEKPFVDENDEPSLYPNKKWLAKRDRLSPGPIPGNNLRPYLDNSSNLRYDGDGANVTNDQLTLFINATMYRPFHTNVNSQEWYQLFEDIMTNASGRPHWAKNFIGVNGAHRTDQDLRKQLEFGGKTSYSMKGFNPILKKWFGENLVEYNKVRESMDPDNVFLSGKDWAVRNGILIDV
What are the official names of this protein?
D-arabinono-1,4-lactone oxidase, ALO, L-galactono-gamma-lactone oxidase.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion membrane. Note=Membrane-embedded.