PharMolix/UniProtQA huggingface dataset:
Protein: ATPA_RHIEC
Sequence: MDIRAAEISAILKDQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINATRRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAILLDAFLNQKAIHDNGPEGEKLYCVYVAVGQKRSTVAQFVKVLEERGALKYSIIIAATASDPAPMQFLAPFAGCAMGEYFRDNGMHALIGYDDLSKQAVSYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDKGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVAQVGKFEQGLLSYLRSEGSAILDAIRTEKAISDDTKGKLTAALDSFAKSFQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TTHY_SHEEP
Sequence: MASFRLLLLCLAGLVFVSEASPAGAGESKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSDSGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
What is the function of this protein?
Thyroid hormone-binding protein.  Probably transports thyroxine from the bloodstream to the brain (By similarity).
What are the official names of this protein?
Transthyretin, Prealbumin.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIG_BRADU
Sequence: MQQNTSATAQPGSTVDAAEIAKFSKLSAEWWDPKGKMAPLHRINPLRLGYIRDAACRKFERNVRSLNCLGGLRVLDIGCGAGLLCEPLSRLGAQVIGVDPSQSNIAAAKLHADKSHLAIDYRCTTVEEIDPRERFDIVLAMEVVEHVVDVGVFLKRCAAMLKPNGLMVVSTLNRNWKSFALAIVGAEYVLRWLPRGTHEWNKFVTPDELTKYLLDNRLVITEQTGVVYSPFADKWTLSSDMDVNYMVVAEGMV
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: ARP21_HUMAN
Sequence: MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSEREKEKDKNKDKTSEKPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSVIINKTSSTRIPEQRFCEHLKDEKGEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDSVCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSSSENELKWSDHQRAWSSTDSDSSNRNLKPAMTKTASFGGITVLTRGDSTSSTRSTGKLSKAGSESSSSAGSSGSLSRTHPPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPLVTQRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQQLPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTSTTQQYRPMAPVQYNAQRSQQMPQAAQQAGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPATGMPVYCNVTPPTPQNNLRLIGPHCPSSTVPVMSASCRTNCASMSNAGWQVKF
What is the function of this protein?
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
What are the official names of this protein?
cAMP-regulated phosphoprotein 21, ARPP-21, Thymocyte cAMP-regulated phosphoprotein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRP2_SCHPO
Sequence: MILARDDKWTLGSIALIFVLLIGFALLFLLERFRVKEKSRTFKDCVNVYQCPSKGERVYLALRHWFIFLATHKAQMTLILSPLVMLVTIPFTGKETKNSIASYDWNLTGVAARLGYLSCGLFFVSYFFSLKNNPFCLMLFSSHEKMNYLHRWLSVYAVLISVLHGILFMIFSAQSYKPLLYDKISIYGYFITVVLFLMTVASLPSVRRKFFEWFFVLHHTCSVLIIFLIWLHHPRTIVYMKACIIIYAFDRGCRLFRSIWNRSNFRIYLLNEDMIYMVGRKPKRSFFALPWAAGSHVYINIPSLSYWQVHPFTLASAPFDDFIELFVAVHSGFTERLANRLYSMPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHTYEPEDLYLETTVFMDGPYGTTSNVFKEYSYVLLIAGGVGFSYTLPILRDLILKECNVTSITFIWSCRSLSLLKVASKSLNSLLHQSNVRLKIINHFTGSISCKESSEFSNQTTENSEMEFFDDRPDLDMYIQKFFDYVGYQTAALAACGSQSFLKRIKNSVNKSISSTTDIYQHYEEL
What is the function of this protein?
Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity).  Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity).  Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity).  Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).
What are the official names of this protein?
Ferric/cupric reductase transmembrane component 2, Ferric-chelate reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferric reductase (FRE) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PROA_MARMM
Sequence: MSDRMQAYIEQLGRQARAASRVLATASTERKNAALIAAAAALRLRANDLLEANRIDVDGVRKAGKPDAFIDRLMLDGARIEGVASAVEAIATLPDPVGRVLAEIDRPNGLRIERVAVPLGVIGMIYESRPNVGADAGALCLKSGNAVILRGGSESLNSTRIIVECMKEGLREADLPEDAIQMIDTANRDAVKHLLQCTQFVDLVIPRGGKGLVTLVRDQARVPTLLHLDGNCHTYVHAGADLDKAVAIIENAKLRRTGICGATESLVIDESVAADLLPRLIDRMTVCEFRGDPAAVTIDPRVKPADDSDWDTEYLDACLSVKIVDGLEAGINHVAAHSSGHTDAIVTEDADAATCFLAMIDSAVVMHNASTQFSDGGEFGMGAEIGIATGKMHARGPVGLEQLTSFKYLVHGEGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_ACIBT
Sequence: MADIRITGRMVNFSRITFDTNDHDVIRQQLSNILNEGSYQGTVVIIDSTVEQELIALIQLLVSMGLQPMAVIDGILGDEARAIQFPVLPADQPLQRIKPTAEQVAIVEKPTSAQASVETKKPLNNNAVAHITSYHDEILRTGQSLVQDQGDIILKAGMNSGSEVIASGNIHIYGTVRGRVIAGAGGHAAARIFCQSLEAELVSIAGTYCVADDIPKHVVKKPVHIYLNEKQELEFEALEL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: MURR_SHIDS
Sequence: MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVTCEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: DSBE_SALTY
Sequence: MKRNVLLLPLLIFLLIAAALLWQLARNAQGDDPTNLESALTGKPVPAFRLESLETPGQYYQAEVLTQGKPVLLNVWATWCPTCRAEHQYLNQLSAQGIRVVGLNYKDDRAKAVAWLKELGNPYALSLSDSDGMLGLDLGVYGAPETFLIDGRGIIRYRHAGDLNARVWESELKPLWDRYSREAAQ
What is the function of this protein?
Involved in disulfide bond formation.  Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme.  Possible subunit of a heme lyase (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbE, Cytochrome c biogenesis protein CcmG.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: NTAQ1_DROVI
Sequence: MTTDFLFPKIADCSYVSCYCEENVWKLCEQVKRTRPEELSKCYAVFVSNEGRTVPLWRQKAGRGDDQVVIWDYHVFFMHNPLPNRCLVFDLDTTLPFPTYFHKYVTETFRSDLALRPEHHRFFRVIPADTYLIEFSSDRRHMRRPDGSWIKPPPSYPPILSNTNLHCLGDFICMSAGKGPGAVYSLSEFVQNFYKSPHVGVQQNK
What is the function of this protein?
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation.  Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.  Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
What are the official names of this protein?
Protein N-terminal glutamine amidohydrolase, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, Protein tungus.
What is the protein family that this protein belongs to?
Belongs to the NTAQ1 family.
Protein: PP2C4_YEAST
Sequence: MGQLLSHPLTEKTIEYNEYKNNQASTGIVPRFYNCVGSMQGYRLTQEDAHLIRNENSVVYVRFFNPFIDKYETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYTSTTNNDSSKFKRSFNTLEGLVSQIFKDAFILQDEELYRHFANSSCGSTAVVACIINEESLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVSLGRVGGVLALSRAFSDFQFKRGVTYPHRRTKLTNITQNLTYGTPPQEAQVTVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNTGVGFDNMTAIIVVLNRKGETLQDWFNKMKTRLERERGLV
What are the official names of this protein?
Protein phosphatase 2C homolog 4, PP2C-4.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: Y1352_STAAW
Sequence: MSETLNQIKESFIEYLLFQYRFKSRIAVWVLNYIKVNEAKLANIHFVDTKINHHETLEIAEVGSHASAIQFTKRNIKLMNTNEIFDYIANHNCAFDIQIHFANVSKREQRLDDLIVAQLTESPSYQTYLHDLNSMAIDRHKHALLIDYLLHNIDLSLQMNEKQRFYQLTQILNTLKLVNKHNQFEDLADDD
What are the official names of this protein?
UPF0302 protein MW1352.
What is the protein family that this protein belongs to?
Belongs to the UPF0302 family.
Protein: HIS6_DESVH
Sequence: MLSKRIIPCLDVRAGRLTKGVKFEGNVDIGDPVATARRYYEEGADEIVFYDITASHEDRGIFLDVVERVASEIFIPFSVGGGINTVDDMRAVLMAGAEKVSVNSGAVKTPDIISQGAAAFGSQAIVVGMDVKQVEKSATIPSGYEIVIHGGRKYMGMDAIEWAKTCESLGAGELCVNSIDADGTKDGYELTLTRMISDAVTIPVIASGGAGSPEHMYDALTRGGASAALIASIVHYGTYTIPDLKRRISGMGAKMRMVW
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDX_SHIFL
Sequence: MKLNFKGFFKAAGLFPLALMLSGCISYALVSHTAKGSSGKYQSQSDTITGLSQAKDSNGTKGYVFVGESLDYLITDGADDIVKMLNDPALNRHNIQVADDARFVLNAGKKKFTGTISLYYYWNNEEEKALATHYGFACGVQHCTRSLENLKGTIHEKNKNMDYSKVMAFYHPFKVRFYEYYSPRGIPDGVSAALLPVTVTLDIITAPLQFLVVYAVNQ
What are the official names of this protein?
Uncharacterized protein YidX.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: VATF_HUMAN
Sequence: MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit F, V-ATPase subunit F, V-ATPase 14 kDa subunit, Vacuolar proton pump subunit F.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Protein: PURR_ECOLI
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB).  Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes.  The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: MDH_FRANO
Sequence: MARKKIALVGAGNIGGTLAHLALLKQLGDVVLFDIAQGMPNGKALDLLQTCPIEGVDFKVRGTNDYKDLENSDVVIVTAGVPRKPGMSRDDLLGINIKVMQTVGEGIKHNCPNAFVICITNPLDIMVNMLQKFSGVPDNKIVGMAGVLDSARFRTFLADELNVSVQQVQAYVMGGHGDTMVPLTKMSNVAGVSLEQLVKEGKLKQERLDAIVSRTRSGGGEIVALLKTGSAYYAPAAAGIQMAESFLKDKKMILPCAAKVKAGMYGLDEDLFVGVPTEISANGVRPIEVEISDKEREQLQVSINAVKDLNKAAAEILAK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: ATZ1_CAEEL
Sequence: MASIELRNVQTELAAKNLQFKVLTEKFLEQRKELFDAKKTDSNVEYVECLSEKLRVATERISDLEKETKEGKQVANEEIGRLEKLLREAQQKRDAKIDESYQTFLRIELLVANLGESTDPENEKRIKNLMPAAKTGIPPEGVLRLTINALDSAARESKKKTMAIESLTKQVDDANKLTEVYMKRLEELEDKHRFEEALTLKIQAMMIETTGQLEAQKKIIADLQKKNDDLMKEEEGEEDYEEEENYEVEEDFEDEEEYDEEGEEEDYE
What is the function of this protein?
Plays a role in meiosis, germline development and oocyte morphogenesis (PubMed:28696027).  May play a role in DNA replication (PubMed:28696027).  In the germline, involved in the maintenance of transition zone nuclei and in chromosome structure and organization, but not required for mitotic proliferation (PubMed:28696027).
What are the official names of this protein?
Protein atz-1, Abnormal transition zone 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: UNG_COXBN
Sequence: MTTMAETQTWQTVLGEEKQEPYFQEILDFVKKERKAGKIIYPPQKDIFNALKLTPYEAVKVVILGQDPYHGPNQAHGLAFSVRPGVPAPPSLQNIFKELHADLGVSIPSHGFLEKWAKQGVLLLNAALTVEAGKPQSHANIGWHRFTDKVIESLNDHPEVIVFLLWGSYAQKKSQLITNLRHRILKAPHPSPLSAARGFLGCRHFSKANQLLHEMGRGEIDWALD
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EUTC_LISMF
Sequence: MNEQELKQMIEGILTEMSGGKTTDTVAAAPTKSVVETVITEGSIPDITEVDIKKQLLVPEPADREGYLKMKQMTPARLGLWRAGPRYKTETILRFRADHAVAQDSVFSYVSEDLVKEMNFIPVNTKCQDKDEYLTRPDLGREFDNEMVEVIRANTTKNAKLQIVVGDGLSSAAIEANIKDILPSIKQGLKMYNLDFDNIIFVKHCRVPSMDQIGEITGADVVCLLVGERPGLVTAESMSAYIAYKPTIGMPEARRTVISNIHSGGTPPVEAGAYIAELIHNMLEKKCSGIDLK
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: TXC1B_CUPSA
Sequence: GFGSLFKFLAKKVAKTVAKQAAKQGAKYIANKQME
What is the function of this protein?
Has antimicrobial activity against E. coli, E. faecalis, P. aeruginosa, and S. aureus.  Has insecticidal and hemolytic activities.  Probably acts by disturbing membrane function with its amphipathic structure.
What are the official names of this protein?
Cupiennin-1b, Cu-1b, M-ctenitoxin-Cs1b, M-CNTX-Cs1b.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: E2AK3_MOUSE
Sequence: MERATRPGPRALLLLLFLLLGCAAGISAVAPARSLLAPASETVFGLGAAAAPTSAARVPAVATAEVTVEDAEALPAAAGEPESRATEPDDDVELRPRGRSLVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLITYGLSAYSGKLRYICSALGCRRWDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKPGGNKEDSKIISDVEEQEATMLDTVIKVSVADWKVMAFSRKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTASEEALGDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTSPKALESVNGENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESETQCQTESKYDSVSADVSDNSWNDMKYSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEQIEVIAPSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTVDGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENLEFPGKTVLRQRSRSMSSSGTKHSRQPSCSYSPLPGN
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:9930704, PubMed:11106749, PubMed:23921556).  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (PubMed:9930704, PubMed:11106749, PubMed:23921556).  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:11106749, PubMed:23921556).  Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797).  Involved in control of mitochondrial morphology and function (PubMed:23921556).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RS4A_CLOBL
Sequence: MARYTGATCRLCRREGLKLFLKGDRCYTDKCAFARRGYAPGQHGQSRKKVSNYGLQLREKQKAKRIYGILERQFRGYYEEADRRRGITGENLLRLLEMRLDNVVYRLGYGNSRTEARQLVTHGHFLVNGKKVDIPSYQVSANDVITVCDKSKATEKFKTFAENPKTLPAWLSGNVEGFEGKVERQPAREDIDVPVNETLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RRF_ENT38
Sequence: MISDIRKDAEVRMEKCVEAFKNQISKVRTGRASPSLLDGIIVEYYGTPTPLRQLASVTVEDTRTLKINVFDRSLGPAVEKAIMASDLGLNPSSAGTDIRVPLPALTEERRKELIKVVRGEAEGARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKLDAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_SYNS3
Sequence: MPPRPRFDRRAPVRELPNINDRINYPQLRVVDADGEQLGVIDREQALEVARERELDLVLVSEKADPPVCRIMDYGKFKFEQEKKAKEAKKKSHQTEVKEVKMRYKIDQHDYDVRIGQAQRFLKAGDKVKCTVIFRGREIQHTALAEVLLRRMAKDLEEPAEVQQPPKREGRNMIMFLTPRKAPLVKKDKDEEVVNKAVRTIPSPARRINTQD
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_STRA1
Sequence: MSILINSTTIGDIIIVSGSVLLLFILIKTFAWKQITGIFEAREQKIANDIDTAEQARQQAEAFATKREEELSNAKTEANQIIDNAKETGLAKGDQIISEAKTEADRLKEKAHQDIAQNKAEALADVKGEVADLTVLLAEKIMVSNLDKEAQSNLIDSYIKKLGDA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GPDA_STAAC
Sequence: MTKITVFGMGSFGTALANVLAENGHDVLMWGKNQDAVDELNTCHTNKKYLKYAKLDVNIIATSDMTKAIQFADIYLMALPTKAMREVASQINDKLTSKKTFIHVAKGIENGTFKRVSEMIEDSISPEYNAGIGVLSGPSHAEEVVVKQPTTVAASSKDKSVSKLTQDLFMNDYLRVYTNDDLIGVELGGALKNIIAVASGIVAGIGYGDNAKAALMTRGLAEISRLGEKLGADPMTFLGLGGIGDLIVTCTSTHSRNFTLGYKLGQGESMDQALSEMNMVVEGIYTTKSVYHLAKEKNVDMPITNALYRVLFENISVKECVKDLMERDKKSE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.