PharMolix/UniProtQA huggingface dataset:
Protein: Y1068_METJA
Sequence: MSYKEKAVKGVSWHLLSYFLAAPIAYLVRVLYANEIPKLDVGLFYAVLDFFSMLVVFRAFGLDQALIRYIPKYLAENRLDMLKSSIVFVGILQTILAFIVAFLVVIFAPYIAEFYINNQGQFTGRLDLVINILIIMAMGYYFLDSIVAFFSNILTGFQLQNYASSTRVVRILSVFIFSLIFIYLFNVHNAYVPSVSYLLMAVVMIIIYGYIVVKKIFPKFAKEKVIFSRKLIRNLFSYGMYVMIGYAGSLILGYLDGICLTYFTGLNAVADYRNVAMPTVNILSYFAFSVGAVLFPMSSELWEKGYKKALSYGVEKVFLYSLIIVTPLAILMAYFPTVIINILFNPKYLSAAPAIQILSFGAMFLTFNSIGFNILNGIGRPNISTKILYIGASFNLIFNILLIPKFGIIGAAITTVFGYFIMWIFQIWFLNKLLEHQFLNKKWILVILVGIFSLIPVMFIKDLIDNVILQLFVCGVVYFGIYILGIFGLKIINIYEVKDIISKIIKR
What are the official names of this protein?
Uncharacterized membrane protein MJ1068.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPI16_SCHPO
Sequence: MKKNGCLLLFAYSLLSFSLTAATIDETYDESLFIKSFSSRYSYVSFAFEIGASTDSTHSSVFSESSFSLFPLSIARVMDECQVSELHIRATRGRWDYENWKESPDNGFYSGGLGFEVWAFMANDPSMKYWLKLTNQLSGLLCASLNYIDSSNTYQPQLSYPGSFSFSNNTQYFASLPQEDVCTENLSPLFKLLPCKRKAGIASLLDSHLFFDTDWHSFSIDVYPSENQSLASVKMGIIIQAVVDVERNGRRKGKTTFQPPSEYCHDEDMDSLHCLMSGYSTEHHTVDDLFHKVPKERCLLSSTFSDVFVSNGDKIDTFSLDEAANIQIPIQSTSDNHTVTVDRSLSNDGNHWGSLSSTIYNPSSSPRTIVYFEKFPWFVRVYLHTLTITLNGTRINTKDFIEKLYYQPLRDRKAGTMMEIQFSIPPHTNLIVHFNVEKTPLRLDEYPPDANRGYNLPPAIISVFDENNTKLCSLRTAALLMFIPTPDFSMPYNVIIFTSTVIALTFGGIFNLLTRRFVPQQSKFQNRQPSMLQRLKEKIFHKKRG
What is the function of this protein?
Component of the GPI transamidase complex.  Involved in transfer of GPI to proteins (By similarity).
What are the official names of this protein?
GPI transamidase component PIG-T homolog.
What is the protein family that this protein belongs to?
Belongs to the PIGT family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RS4_MYCBT
Sequence: MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKESEYLLQLQEKQKARFTYGVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGLARTRRMARQLVSHGHFNVNGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGERPIPSWLQVVGERQRVLIHQLPERAQIDVPLTEQLIVEYYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: YNP0_YEAST
Sequence: MMQVATSVMVRLFYQKTIEKLKTKQCHNDKEEPIHTQRAYSSSSSSISASLSGSNPWFLLLASSKAFSNNSCCLLTLLLVFLPQPKEVVSAVAASSGLSIRSFDLFSSLSRLSFSTWAANCFFANSLDAIFLKSK
What are the official names of this protein?
Putative uncharacterized protein YNL150W.
Protein: ATP8_RABIT
Sequence: MPQLDTSTWFTTIVAMILSLFILMQLKFHKYTYPMNPVLKALESTSFPCPWETKWTKIYSPLSLPQH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, Chargerin II, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RS2_SHELP
Sequence: MTTVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGARNGVHIINLEHTVPMFNEALAFISNVASKKGKVLFVGTKRAASEAIKEAAISCDQYYVDNRWLGGMLTNWKTVRQSIKRLKDLESQSVDGTFDKLTKKEALMRTRELEKLEKSLGGIKNMGGLPDVIFVIGADHEHIAIKEANNLGIPVVAVVDTNSSPDGINYIVPGNDDAMRAIRLYAESVAAAAKAGRGQDLAVQAEQDGFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YADH_SHIFL
Sequence: MMHLYWVALKSIWAKEIHRFMRIWVQTLVPPVITMTLYFIIFGNLIGSRIGDMHGFSYMQFIVPGLIMMSVITNAYANVASSFFGAKFQRNIEELLVAPVPTHVIIAGYVGGGVARGLFVGILVTAISLFFVPFQVHSWVFVALTLVLTAVLFSLAGLLNGVFAKTFDDISLVPTFVLTPLTYLGGVFYSLTLLPPFWQGLSHLNPIVYMISGFRYGFLGINDVPLVTTFGVLVVFIVAFYLICWSLIQRGRGLRS
What are the official names of this protein?
Inner membrane transport permease YadH.
What is the protein family that this protein belongs to?
Belongs to the ABC-2 integral membrane protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPB_STRA3
Sequence: MSSGKIAQVVGPVVDVVFASGDKLPEINNALIVYKNGDKSQKVVLEVTLELGDGLVRTIAMESTDGLTRGLEVLDTGRAISVPVGKDTLGRVFNVLGDAIDLEEPFAEDAERQPIHKKAPSFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQMGIYPAVDPLASSSRALTPEIVGDEHYEVATEVQRVLQRYRELQDIIAILGMDELSDEEKTLVGRARRIQFFLSQNFNVAETFTGQPGSYVPVEETVRGFKEILDGKHDQIPEDAFRMVGGIEDVIAKAEKMNY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBFA_RHOPS
Sequence: MSRHQKPTGQSESPRKLRVGELVRHAVAEILAQGGVHDPVLETHLITVPEVRMSPDLKLATVYVMPLGGRDEKLVIAALEQHKRFLRGEVARRVNLKYAPEIRFRIDERFAEAERIEKLLRTPAVQKDLEPDSDQD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPHN_EUPCP
Sequence: FLNALKNFAKTAGKRLKSLLN
What is the function of this protein?
Has antibacterial activity against E. coli HP101BA (MIC=6. 4 uM), K. pneumoniae PTCC1388 (MIC=7. 3 uM), M. luteus PTCC1625 (MIC=4. 7 uM) and S. aureus PTCC1431 (MIC=5. 3 uM).  Has no or very limited (<3%) hemolytic activity at concentrations of 15 ug/ml and 60 ug/ml, respectively.
What are the official names of this protein?
Cyanophlyctin.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL35A_RAT
Sequence: MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Required for the proliferation and viability of hematopoietic cells.
What are the official names of this protein?
60S ribosomal protein L35a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_NITHX
Sequence: MSDASRISPLDQARILSEALPHMQQYDEETIVIKYGGHAMGAEDVARQFARDIVLLEQTAINPVVVHGGGPQIATMLQRLGIKSEFAAGLRITDAATIEIVEMVLAGSINKQLVGYINEAGGKAVGLCGKDGNMVTASKATRTIADPDSNIEKVVDLGFVGEPEKVDLTLLNQLIGHELIPVLAPLATSKGGQTFNVNADTFAGAVAGALKAKRLLLLTDVPGVLDKSKKLIPDLSIGDARKLIADGTISGGMIPKVETCIYALEQGVGGVVIIDGKTPHAVLLELFTDQGTGTLIHK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEA_PROMS
Sequence: MTNFEPKKFKNIWTIEDSISSYNIDKWGDKYFSINSKGNISVTKDIKSENKIDLFKLVKELKSREINPPLIIRFNDILKDRINALHDSFLKAIKTYKYKNIYQGVFPVKCNQQKNVLEKIIEFGSQWNFGLEVGSKSELLIGLALLENQNSLLICNGYKDKKYIEIATLARKLGKNPIIVIEQRDEVKRIIQAVQELKATPLIGIRAKLSSKSSGRWGKSIGDNSKFGLSIPEIMLTIKELKEANLINEMKLLHFHIGSQISDIAVIKDALQEASQIYVELCKLGAPMQYIDVGGGLGIDFDGTKTSSNTSTNYSLQNYANDVIATIKDSCELNNIKHPTIISESGRAIISHCSVLIFNVLGTSHVSSKLQIFDKKNQQLIISNLLDTFYELKKLKNKKINLSQIIELWNDAKKFKEDCLVAFRLGFLSLAERAYAEELTWACAKEISNNLNNDEINHPDLSEITETLASTYYANLSIFKSIPDSWAINQIFPIVPIHRHLEEPFCKGNFADLTCDSDGKLNNFIDNGKIKSLLNLHKPEEDKDYLIGIFMTGAYQEALGNLHNLFGSTNVVHIDINQDNSYKVRNIIKEDSKSEILQLLDYSSASLVESIRINTESAIDQKKLTIEEARKLMDQIEISLRKSSYLSE
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: RISB_DESRM
Sequence: MPKVFEGHLLGQELKFGIVVGRFNEFITNKLLSGALDALKRHGVEDENVEIAYVPGAYEIPLVAKKMADSKRYDGVICLGAVIRGATPHFEYVSAEVSKGVAKISLDSNLPVIFGVLTVDTIEQAIERAGTKAGNKGWEAANAAIEMANLLKTI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: FADB_ECOLU
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLVEGAMAILRQAINGDLDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDIVVEAVVENPKVKKAVLAETEQKVRPDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGDLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: RL7_LACLS
Sequence: MALNIENIVAELENATILELSELVKAIEEKFDVTAAAPVAAAAGAGEAAAAKDSFDVELTAAGDKKVAVIKEVRGITGLGLKEAKELVDGAPTVVKEGLSESEANEIKEKLEAAGASITLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PP2BB_HUMAN
Sequence: MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ
What is the function of this protein?
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:32753672, PubMed:26794871).  Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672).  Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).  Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138).  Dephosphorylates DARPP32 (PubMed:19154138).  Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity).  May play a role in skeletal muscle fiber type specification (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, CNA beta.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2B subfamily.
Protein: RPPH_FRAT1
Sequence: MIDKSGYRANVAIVLLNKQNRVFWGQRRNRTSWQFPQGGVATGETPLQAMYRELHEEIGLRPQDVEVIASTRDWYKYDIPDSLVRTKEPICIGQKQKWFLLKLKSPESYIDLDANDSPEFDNWRWVSYWYPINHVVYFKQEVYRKALTYFKEYIA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: Y1977_YERPY
Sequence: MMKINNLPRLIRAFLPATLLMLPLVWQTPALAQSASCTQGSTCVSVGGNNDPMSKEQARQSQQQWDETNRLRNKMNNRVEKDFDKNDRAVDAKDNCERSDNLNAYWEPNTQRCLDRLSGRKINP
What are the official names of this protein?
UPF0482 protein YPK_1977.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: HISX_PELUB
Sequence: MIKILDSKNKNFDKTLDALLSKRKNKVQLNSVSVIKIIKDVKKNGDKAILKYEKRFNKNSIIAPSIKQINRAIQSLDQKVKKAIDLAYDRIYKFHSLQKFKNISYTDKLKNKLEYKYVPIESVAIYVPGSTASYPSSVLMNAVPAIVAGVKRLVMVNPGQKGKQNPAVLYAAKKCKIKEIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGNSYVAAAKKEVFGDVGIEGMIAGPSEVTIVCDKFSNPEWIASDLIGQAEHDNLAQCILISKDKSIIKKVNYEIINQLKELPRAVIAKNSLLNNGILIYMPSDQKIINTVNKIAPEHLELNTKNYKKVVSKIKNAGSICLGKYAVMAMTDYNVGSNHVLPTNSSARYSSGVSVNEFYKRISYINLSKKGIETLGPSVITLANYEGLVGHAKSVEKRIRRK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: EFTU_GONPE
Sequence: KNMITGAAQMDGAILVVSGADGPMPQTKEHILLAKQVGVPNIVVFLNKEDQVDDKELLELVELEVRETLDKYEFPGDEIPVIPGSALLALEALIENPKTQRGENPWVDKIYQLMDKVDSYIPTPQRETDKPFLLAVEDVLSITGRGTVATGRVERGTLKISDTVEFVGLKPTQSAVVTGLEMFKKTLDETLAGDNVGVLLRGVQKKDIERGMVIAKPGTITPHTKFEAQVYVLTK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, chloroplastic, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TAL_CHLTR
Sequence: MSSQFDQLKLWSVLVGDTGDPALIKTLGVQDATTNPSLILKVAQEPKYQSMLTEAISWGIRQNGDDVQTLTFVLDKIQVNLGLEILKHVPGRVSLEIDARLSFNTEAMVQRAIFLSQLFEKMGGDKKRLLVKIPGTWEGICAAEVLESQGIACNVTLIFNLVQAIAAAKAKVTLVSPFVGRIYDWWIAAYGAEGYSIEADPGVASVANIYSYYKKFDIPTQIMAASFRTKEQVLALAGCDFLTISPKLLEELKKDQQPVERKLSVEEAKKLDIQPVELSESVFRFLMNEDAMATEKLAEGIRIFSGDTQILESAVTEFIRQIAAQEA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_BORPE
Sequence: MDDRARALLKALIERYIADGQPVGSRTLSKVFDLSPATIRNVMADLEELGLIHSPHTSAGRVPTPRGYRMFVDSLLAVRAYQFEPAHIGELLPVSEPSRAVNAAAALLSNLTQFAGVVLTPKRTQIFRQIEFIRLSDKRVLLIIVTPEGDVQNRILSAQRDYTEAELLEAGNFFNVHFSGKSFDAVRRTLSTELAQLRDDISRLMQAAVEAGAEAADDGEAVVISGERKLLDVTDIASDMDRLRKMFSLFEKKTDLLQLLDVSSRAQGVQIYIGGDSQLVPMEEVSVITAPYGVDGKVIGTLGVIGPTRMAYERVIPIVDITARLLSNALSHNQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: METK_SPHAL
Sequence: MRNSFLFTSESVSEGHPDKVADQISDSIVDLFLAKDPEARVACETLTTTQLVVLAGEIRCKGVFEDGEWAPGALDEIEATVRRTVREIGYEQAGFHWNRFRFENNLHGQSPQIAQGVDEGAGKDEGAGDQGIMFGYASDETPDFMPATLDYSHKILERMASDRKAGIAPFLEPDAKSQVTLRYANERPVEATAIVVSTQHAPGYYFHNGEGDEAKYTELRKYVLGVIADVLPAELLTANTVYHINPTGRFEIGGPDGDAGLTGRKIIVDTYGGASPHGGGAFSGKDPTKVDRSAAYITRYLAKNIVAAGLARRCTIQLSYAIGVAEPLSIYVDLHGTGTVDEGRIEAVLPQLVRLTPKGIRTHLGLNKPIYRQTAAYGHFGRQADGDAFPWERTDLVDKLKAALAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MARC_SALPA
Sequence: MMDLFKAIGLGLVVLLPLANPLTTVALFLGLAGNMNSAERNRQSYMASVYVFAIMMVAYYAGQLVMNTFGISIPGLRIAGGVIVAFIGFRMLFPQQKAHESPEAKSKSEELADEPTANIAFVPLAMPSTAGPGTIAMIISSASTVRHGGEFPDWVIMVAPPIIFLAVAVILWGCLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIIKTYH
What are the official names of this protein?
UPF0056 inner membrane protein MarC.
What is the protein family that this protein belongs to?
Belongs to the UPF0056 (MarC) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BAIN_CLOS5
Sequence: MNRIGIIGGGASGIVAAIAAARSDGDAQVFILEQKENIGKKILATGNGRCNLTNEAMDASCYHGEDPEFARNVLKQFGYGETLEFFASLGLFTKSRGGYIYPRSDQAASVLELLEMELRRQKVKIYTGVRVEALKLSAKGFVIRADGQRFPADRVILACGGKASKSLGSDGSGYALARSMGHTLSPVVPALVQLKVKKHPFAKAAGVRTDAKVAALLGRQVLAEDTGEMQITAYGISGIPVFQISRHIAKGLYEGKEMKVRVDFLPEMEASQVRKAFNTHLDKCPYATCQEFLTGIFPKKLIPRLLELSHIRQNFPASELKPAQWEDLIRACKQTLLTIEDTNGFDNAQVCAGGVRTGEVYPDTLESRYADGLYLTGELLDVEGICGGYNLQWAWATGYLAGRAAAERP
What is the function of this protein?
Involved in the secondary bile acid metabolism.  Catalyzes two subsequent reductions of the double bonds within the bile acid A/B rings of 3-oxochol-4,6-dien-24-oyl-CoA and 12alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA to yield 3-oxocholan-24-oyl-CoA and 12alpha-hydroxy-3-oxocholan-24-oyl-CoA, respectively.
What are the official names of this protein?
3-dehydro-bile acid delta(4,6)-reductase.
Protein: DNAK_PARXL
Sequence: MGKIIGIDLGTTNSCVAIMEGNSVKVIENSEGARTTPSIIAYMEDGEILVGAPAKRQSVTNPKNTLYAVKRLIGRRFEEKEVQKDIGLMPYKIIKADNGDAWVEVRDQKLAPPQISAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKNEKGDRKIAVYDLGGGTFDVSIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKESAEKAKIELSSSQQTEINLPYITADASGPKHLNLKITRAKLEALVEELIERTIEPCRVAIKDAGVKVGEIDDVILVGGMTRMPKVQEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMINKNTTIPTKHSQVYSTADDNQGAVTIKVFQGEREMAAGNKLLGEFNLEGIPPAPRGTPQIEVSFDIDANGILHVGAKDKATGKENRITIKANSGLSEAEIEKMVKDAEANAEEDHKLRELADARNQGDALVHSTKKALTEYGDKLEAGEKEKIESALKDLEETLKSGSSDKAAIEAKIEVVATASQKMGEKMYADMQAAQGAEAAAAGAAGAGGAGASAGGASQQQDDVVDAEFKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HIS2_METS5
Sequence: MTDVLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSETADLIYHLLVLLAMEGISLDEVRDELRRRMK
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRCA_ECOBW
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: MBL2_PANTR
Sequence: MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAVRNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense.  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPH_CROS8
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSNPEGGMYLVESPEDVWKITVKDENNLSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHELTGREENIVFEVPKELRIDAREVQ
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: MGSA_ECOSM
Sequence: MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.