PharMolix/UniProtQA huggingface dataset:
Protein: KCAB2_XENLA
Sequence: MYPESTTDSPARLSLRQTGSPGMIYSARYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLDYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDGGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKEFQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLLENIGAIQVLPKLSSSIIHEIDGILGNKPYSKKDYRS
What is the function of this protein?
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:10594054).  Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity).  Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity).  Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity).  Promotes KCNA4 channel closure (By similarity).  Modulates the functional properties of KCNA5 (By similarity).  Enhances KCNB2 channel activity (By similarity).  Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity).  Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).
What are the official names of this protein?
Voltage-gated potassium channel subunit beta-2, K(+) channel subunit beta-2, Kv-beta-2.
What is the protein family that this protein belongs to?
Belongs to the shaker potassium channel beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated.
Protein: RS18_ERYLH
Sequence: MARPFFRRRKTCPFSAKNAPKIDYKDTRLLQGFMSERGKIVPSRITAVSAKKQRELAKAIKRARHIGLLPYIVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PDXH_ALTMD
Sequence: MAISDMRRQYSKGSLSESDITSSPFSLFDQWLKDAIDAGIPDPTAMTVATVDSTGQPSQRIVLLKDVSDKGFVFFTNLGSRKAQELSVNPKVSCHFPWFFMERQVRVCGSVEKLSVSENAAYFFSRPKDSQLAAYASKQSKPIGSRALLLTQFKQLKDKFANKALPVPDFWGGFRIVPHQIEFWQGGEDRLHDRLEYNKAEDGRWSTQRLMP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: NADE_BACC3
Sequence: MTLQEQIMKALHVQPVIDPKAEIRKRVDFLKDYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVEEIRNEGGNVTFIAVRLPYKVQKDEDDAQLALQFIQADQSVAFDIASTVDAFSNQYENLLDESLTDFNKGNVKARIRMVTQYAIGGQKGLLVIGTDHAAEAVTGFFTKFGDGGADLLPLTGLTKRQGRALLQELGADERLYLKMPTADLLDEKPGQADETELGITYDQLDDYLEGKTVPADVAEKIEKRYTVSEHKRQVPASMFDDWWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: UPPP_ACIB3
Sequence: MENFEVIKALFLGFVEGLTEFLPISSTGHLILFGHIIDFHSDGGRVFEVVIQLGAILAVCWLYRQKIINLIKGFFSGDVESRHFAISVLIAFSPAVIIGVLAVDFIKSVLFSPIVVAIALIVGALIIFWVESKQFEHKTDDATKITFKQALLVGLAQCVAMIPGTSRSGATIVGGMFAGLSRKAATEFSFFLAMPTMLGAATFDLIKNADVLTSDNMVNIGVGFVAAFIAALLVVKALVLFVERHTLRVFAWYRIVLGVIILIAAMFFNLSA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPF_HUPLU
Sequence: MKNVIDFVIISGYWPPAGGFGLNANLLETNLINSGVVLGLPVYSGKGVLSNLLNNRKQTILSTIRDAEERYEEATDKLKQARTRLQQAKIKADEIRINGLSRMEGEKQDLVDSADGNSKRLEDSKNATIRFEEQRAIEQVRQQVSRLALERALEVLNIRLNSELQSRMIDYHIDLLVRAAENTTD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NANA_STAAB
Sequence: MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNTIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATEIGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_STRP2
Sequence: MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQVIDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHGRVKALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RL13_TERTT
Sequence: MKTISANSQTVKRDWYIIDAEGKTLGRMAAEIAHRLRGKHKPEYTPHVDTGDYIVVINAEKVRVTGNKAKDKMYHHHTGYIGGLKSISFEKLIQKAPERTIETAVKGMLPKGPLGRAMFKKLKVYAGESHPHTAQQPQALNV
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: AROC_BURVG
Sequence: MSGNTLGTLFTVTTFGESHGPAIGCVIDGCPPGMSLTEADIQAELDRRKPGTSRHVTQRQEADEVEILSGVFEGVTTGTPIALLIRNTDQRSKDYGNIVETFRPGHADYTYWQKYGIRDYRGGGRSSARLTAPIVGAGAVAKKWLRERFGVEVRGCMSALGEIDVPFVDWSHVRENPFFAPNAAIVPELEAYMDALRKDGDSIGARIDVVASGVPVGWGEPVFDRLDADIAKAMMSINAVKGVEIGAGFASVAERGSVHGDELTPAGFVGNHAGGVLGGISTGQDVTVSIAIKPTSSIRTPRRSITKAGEEAIVETFGRHDPCVGIRATPIAESMLALVLIDHALRHRAQCGDVETSTPKIAGSAT
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: SERHL_MOUSE
Sequence: MGLHSELKLAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGGCVGGTFACMFPEMVDKLILLDSTPFFLDSNEMENILTYRRRNIEHTLQVEASQKKSLRAVSPEEMLQGFLNNNSHLDKDCGELILQRGTTKVDAGLVLNRDRRISWPENSFDFVSKEMFVHSAKSLQASVLMIKALQGYYDVRRANDADKAPMHFMVDTLRSTLKERFQFVEVPGNHYIHMNKPQVVAGVVGPFLQGLQRMTSARL
What is the function of this protein?
Probable serine hydrolase.  May be related to cell muscle hypertrophy.
What are the official names of this protein?
Serine hydrolase-like protein, SHL.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Peroxisome. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes.
Protein: CCME_THET8
Sequence: MKGKYLLGILVILGALGYMVFGGLGRNLVYFLTPSEYLQDQARYQNRPVRLGGLVKPGTVQYDKDRLELRFVLTDGVAEVPVFHKGTPPGMFKEGQGVVVEGRFQEGVFQGTNLLVKHSETYQPPKEGWTPEEVRKLIEEAQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: 5HT1B_VULVU
Sequence: MEDAGTPCAPPPPAGSQTGAPPANLSSAPHNCSAEGYIYQDSIALPWKVLLAILLALLTLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYAVTGRWTLGQVVCDLWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSDCVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSVNSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAS
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior.  Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, 5-HTR1B, Serotonin receptor 1B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_SALSV
Sequence: MQKRAIYPGTFDPITNGHLDIVTRATQMFDHVILAIAASPGKKPMFTLDERVALAQKATAHLGNVEVVGFSDLMANFARDRQANILIRGLRAVADFEYEMQLAHMNRHLMPQLESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPDNVHQALMDKLK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STP2_BOVIN
Sequence: MDTKTQSLPNTHAQPHSNSRPQSHACHHCSCSQHCQSRSRSRSCRSRSSSRRPRSHRSPTGRQGQSPGPSPPLRRHRHTMHSHQCPSRPVTHSCSHSKNRKNLEGKVIKRKQVKRSKQVYKRKRQSSGRKYN
What is the function of this protein?
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals.  In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
What are the official names of this protein?
Nuclear transition protein 2, TP-2, TP2.
What is the protein family that this protein belongs to?
Belongs to the nuclear transition protein 2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity).
Protein: PHP14_HUMAN
Sequence: MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY
What is the function of this protein?
Exhibits phosphohistidine phosphatase activity.
What are the official names of this protein?
14 kDa phosphohistidine phosphatase, Phosphohistidine phosphatase 1, PHPT1, Protein histidine phosphatase, PHP, Protein janus-A homolog.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: Y1301_VARPS
Sequence: MLFLLSPAKSLDYDTPVPTEVPATQPHFEAPRGPSAELIKLLREKSPQQISELMHLSEKLSALNVARYQAWSGKGTPKNARQAAFAFDGDVYGGLDARSLTPTQLAWAQEHVCILSGLYGLLRPLDLLQPYRLEMGTPLANRHGKDLYAFWGARIAEHLNQRLAADRTPVVVNVASQEYFRSVDRKALKARVVECVFEEWKGDRYKIVSFYAKRARGLLARWAVLHKAATPKALEKFDLEGYGFDATASTAERLVFRRKFG
What are the official names of this protein?
UPF0246 protein Vapar_1301.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: POTEI_HUMAN
Sequence: MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What are the official names of this protein?
POTE ankyrin domain family member I.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the actin family.
Protein: SSRP_WOLPP
Sequence: MEVIAENRKARFEYFILEEFEAGMILLSSEVKSLRERKANISDAYVTEKKGEIWLNNMHIAEYKAANQKNHKPKRERKLLLHKKEINKLIGQIKTSGITVVPLSIYFNDKGLAKTKIAIVKGKKLYDKRATIKQREWEREKSRLSKNNL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PMEI_ACTDE
Sequence: MAFSYCSSSLFVSLLLVILFISPLSQRPSVKAENHLISEICPKTRNPSLCLQALESDPRSASKDLKGLGQFSIDIAQASAKQTSKIIASLTNQATDPKLKGRYETCSENYADAIDSLGQAKQFLTSGDYNSLNIYASAAFDGAGTCEDSFEGPPNIPTQLHQADLKLEDLCDIVLVISNLLPGSK
What is the function of this protein?
Inhibits pectin methylesterase; may be involved in the regulation of fruit ripening.
What are the official names of this protein?
Pectinesterase inhibitor, AdPMEI, PMEI, Pectin methylesterase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the PMEI family.
Protein: VPS16_MOUSE
Sequence: MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELKDCLVAAAPYGGPIALLRNCWRKEKAASVRPVLEIYSASGLPLASLLWKSGPVVALGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAYRFTLSANVGDLKLRRMPEVPGLQSAPSCWTTLCHDRVPHILLAVGPDLYLLDHATCSAVTPAGLAPGVSSFLQMAVSFTYRYLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWCSRPRSKERAVVVAWERRLMVVGNAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPVASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLIQAVQQCIEAAGHEHQPDMQKSLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAIRDYHIGIPLTYTQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKARAWDMRDEDVARAINQKLGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELDTLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRIQRRLEDELGGRFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLAALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKHEAKKYASRVGPEQKVKALLLVGDVAQAAEVAIEHRNETELSLVLSHCTGATDGAIADKIQRARAQAQKK
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations.  Required for recruitment of VPS33A to the HOPS complex.  Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B.  The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 16 homolog, mVPS16.
What is the protein family that this protein belongs to?
Belongs to the VPS16 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome. Note=Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Protein: PA2A7_AUSSU
Sequence: MYPAHLLVLLAVCVSLLGASDIPPQPLNLYQFGNMIQCANHGRRPTQHYTDYGCYCGKGGSGTPVDELDRCCKTHDDCYTEAGKKGCYPKLTLYSWKCGSDGPQCDDSETGCQRFVCDCDATAAKCFAKAPYNKENYNIKTPCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits collagen-induced platelet aggregation.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Acidic phospholipase A2 S15-109, svPLA2, ASPLA7, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y532_SINMW
Sequence: MATNVLNSIRERGFLDGQFLIAMPGMFDANFARTVIFVCAHSEDGAMGFILNRPQRLTFPDVLLHLQLLDPDEVIRLPSTTREFQIQAGGPVETGRGFVLHSDDYLSDSSIPVSDDICLTATLDIVRAISRGEGPVKATMLLGYAGWGPGQLEAEITQNGWLTCPAQEELIFSRNLDEKYDRALALMGVSPAMLSTDSGHA
What are the official names of this protein?
UPF0301 protein Smed_0532.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: CLPB_YEREN
Sequence: MAITRKNLFGKLDATLFKGIESATTICKLRGNPYVELIHWLNQLWHQEDNDLKHIVRYFAVDVDAFERGLAQALARLPVGATSISDFSYHIELAIERAWVYASLECLDTRIRSGHLLLAMLTNMELRRALLAIAPEMEKIPLEHLSSDFNFITQASPETNEAATDGSPMYDGTLPGEASNAINGKSTATLAQYTTDLTALAREGKIDPVLGRNHEISTMVDILLRRRQNNPLLTGEAGVGKTAVVEGLALAIVAGEMPPALSQVSLLTLDVVALSAGASMKGEFEARLKNVLDEAMASPTPVILFIDEVHTLVGAGGNAGTGDAANLLKPALARGQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDEDTAISMLRGLTPALEKHHGVWIMDEALQAAVRLSHRYIPARQLPDKAISLLDTACARVAVAQFSQPAELQQLTFQSETAQTELSSLEKAQHFGKGQDERTALLEATIAQHSAAANKLEQRWQAERELVTAITATRTVLYELVSQPTPDEEKRQQYQQQLAQLEEQLLLIRSAQPLVQAEVNATVIANIVADWTGIQVGQMLKDDIRAVMELPQRLEERVIGQPHALVQLSENIMTARAGMADPRKPLGVFMLVGPSGVGKTETALAIAESMYGGEQNLITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSVVLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLFADPDTAPDQDGILSALQPELLKVFPAAFLGRVTVIPYLPLQQSALQHIVRLHLDRIGQRLQSQHQLTLQYSDVVVDDVVSRCSVAETGARMLIRYIEQNITPEIGKFILRDHDAIPNQIVFVDKVENKFTVSVLNEKINN
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).  Affects level of invasin and motility in Y. enterocolitica.
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_ECO24
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVSSDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.