PharMolix/UniProtQA huggingface dataset:
Protein: YOR6_CALSR
Sequence: MRTIEYDVVQDMIRNFTEQLQEISNEINSESIKKLAGSIKEKIEKNAFYLVVLGQFKRGKSTLINYMLGANLLPTGVLPLTSVITKIYYSPEVKVDVIFESGVKKEIPVDELDLYCTERGNPKNQKCVDTIEIGYPFDFLNKDVVIVDTPGIGSVYQHNTDVTYEFIDKSDAVVFVLSVDPPITEVEKQFLLKIAENVDKIFFVINKSDLTSKNEIEEIVSFTTNVIKDITKKGNINIFPLSAKMALEGKISKNEEMIEKSCVEIFEKELKQFLKEEKGKIQILSNLKSLDGFLGVCEAFLENDMKLKIMPVKQLEENIEKFNEFLERVNQNKIEIYKLFKIEMNDILQSFDDEMEKIKKELVVKITKKINDYYPSVARLKRIEQKEHLNKYLEKAIVEEFD
What are the official names of this protein?
Uncharacterized protein in xynA 3'region, ORF6.
What is the protein family that this protein belongs to?
To M.genitalium MG148.
Protein: MPC4_ARATH
Sequence: MATSKLQAIWNHPAGPKTIHFWAPTFKWGISIANIADFAKPPEKLSYPQQIAVTCTGVIWSRYSMVINPKNWNLFSVNVAMAGTGIYQLARKIKHDYATEAEPAVASE
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 4.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GCST_PROMA
Sequence: MKSKNTPLYETCLNEGARMVEFAGWNMPIQFSGLINEHNAVRKNSGIFDISHMGVFSIQGKNPKDALQTLVPSDLHRIGPGEACYTVLLNNDGGIIDDLIVYDLGTNDPNNEECILIVINAGCTQADIDWIKEHLSDKNLKVCNAKGDGVLLALQGPDSTNQLRNVLGESLTNIPKFGHREIQVQLKTHPVSFSIFIARTGYTGEDGYEILLNTNAGKSLWRELIENGVTPCGLGARDTLRLEAGMPLYGNDINNTTTPFEAGLGWLVHLETPDEFIGKAALVKQTNEGINKKLVALKIEGRAIARKGYQIMFKNKFVGEITSGSWSPTLNEGIALAYLPIDLTKIGTAVSVQIRDKLHTAIVAKKPFYRRVS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MATK_ERYGU
Sequence: MEESQRYLQLERSQQHDFLYPLIFQEYIYAFAYDRGFSRSSLSENPSYNNKSSLLIVKRLITRMYQQNHFIIYYPNDSNQNTFWARRNNLYSPIISEGFAFIVEIPFSLGLIYCLEGKNKKIVKSQNLRSIHSIFPFLEDNFSHLNFVLDILIPQPVHVEILVQTLRCRVKDASSLHLLRFFLNEYCNSKSLITPQKASSSFSKKNKRLFLFLYNSHLCEYESIFVFLRTKSSHLRSTSLGVLLERIYFYGKIERVVNIFVKVKDFQANLRLVKEPCMHYIRYQRKSILASKGTSLFMNKWKSYLVAFWQWHFSQWFHPRRIYINHISNHSLEFLGYLSNVRMNPSVVRSQIIENSFLINNAIKKVDTLIPIIPLIAAXXKAKFXNVLGHPIXKSVRADLSDFNIIDRFGRICRNLSHYYSGSSKKKSLYRIKYILRLSCARTLARKHKSTVRTFLKRLGSEFLEEFLMSEEDVLFFTFPKASSTLWGVYRSRIWYLDIISINDLANHKSKL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPAT4_HUMAN
Sequence: MAAAGQEKGYLTQTAAALDKSPSLSPQLAAPIRGRPKKCLVYPHAPKSSRLSRSVLRWLQGLDLSFFPRNINRDFSNGFLIAEIFCIYYPWELELSSFENGTSLKVKLDNWAQLEKFLARKKFKLPKELIHGTIHCKAGVPEILIEEVYTLLTHREIKSIQDDFVNFTDYSYQMRLPLVSRSTVSKSIKDNIRLSELLSNPNMLTNELKAEFLILLHMLQRKLGRKLNPEWFDVKPTVGEVTLNHLPAQASGRRYNLKVKRGRVVPVLPNIGSGGSSHREIHVKQAGQHSYYSAMKPIRNMDKKP
What is the function of this protein?
May play a role in apoptosis regulation.
What are the official names of this protein?
Spermatogenesis-associated protein 4, Testis and spermatogenesis cell-related protein 2, Testis spermatocyte apoptosis-related gene 2 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPGG_PSEA8
Sequence: MIFRSVSNTDFRARVRTLLLAGSTALAFVAAPVWAFSIDDVASKAKDLAGDKYSAPTSNLPSEFSEMKFADYQQIRFINERAYWGKLKTPFKLSFYHQGMHFDTPVKINEVTATTVKPIKYDRTKFDFGSLKFDENATKDLGYAGFRVLYPINKADKQDEIATFLGASYFRVVGKGQVYGLSARGLAIDTALPSGEEFPRFREFWIERPKAQDKQLVIYALLDSPRATGAYRFVLRPGKDAVMDVQARVFLRDKVSKLGLAPLTSMYLFGSNQPSEQHNFRPELHDSSGLQIHAGNGEWLWRPLNNPKHLSVSTFSVENPKGFGLLQRGREFSRYEDLDDRYDLRPSAWIEPKGDWGKGTVELVEIPTPDETNDNIVAFWNPETQPEVGKPLDFAYRLHWTMDEDELHDPKSSWVKQTMRSVGDVKQKNLIRQQDGSTALVVDFEGPALKDLAPDAPVTTQVSTDSNAEVVENSLRYNPVLKGWRLTLRIKVKDPKKPVEMRAALVDEAQKPLSETWSYQLPADE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CH10_BORPE
Sequence: MALRPLHDRVIVKRLDNERKTASGIVIPDSAAEKPDQGEVVAVGPGKKTEDGKILPVDLKAGDKVLFGKYAGQTVKVDGEELLVIREDEILAVIQ
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBA5_DROME
Sequence: MKLPALHLLFLGFICLARSQDNDENVRRIMKEMEVIPEILDEPPRELLRIKYDNTIDIEEGKTYTPTELKFQPRLDWNADPESFYTVLMICPDAPNRENPMYRSWLHWLVVNVPGLDIMKGQPISEYFGPLPPKDSGIQRYLILVYQQSDKLDFDEKKMELSNADGHSNFDVMKFTQKYEMGSPVAGNIFQSRWDEYVPELMKTLYGVSE
What are the official names of this protein?
Putative odorant-binding protein A5, Antennal protein 5.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the lumen of the sensilla.
Protein: RR14_LEMMI
Sequence: MARKSLIQREKKRQKLEQKFHLIRRSLKKEISQIPSLSEKWEIHGKLQSLPRNSAPTRLHRRCFLTGRPRGNYRDFGLSGHILREMVNTCLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DUT_YARLI
Sequence: MSLKVAFLNENARAPTRGSVHAAGYDLYAAEEKTIPANGRGLVDLGLSMSIPEGTYARIAPRSGLAVKNGLSTGAGVIDYDYRGPVKVMLFNHSTEDFNVTIGDRVAQMILERIVTPEVQVVQTNDLESTERGAGGFGSTGINDEKKRKLDEAEAKE
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: FTSL_LISMO
Sequence: MSNVAYKSNLEPNRVHREAEQPKKQILKRGQMTLGEKVIITIALAIVLVVAFRIISVQAQIYTVNQEIQTKETKILEQQKSNEDLKVEVKDLGRYERILKIAKEKGLKLDGDNVKVVDGQ
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsL.
What is the protein family that this protein belongs to?
Belongs to the FtsL family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum where it forms a ring structure.
Protein: BIRC2_MOUSE
Sequence: MDKTVSQRLGQGTLHQKLKRIMEKSTILSNWTKESEEKMKFDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLSASLQSPSKNMSPVKSRFAHSSPLERGGIHSNLCSSPLNSRAVEDFSSRMDPCSYAMSTEEARFLTYSMWPLSFLSPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFLENTSETQRFSISNLSMQTHSARLRTFLYWPPSVPVQPEQLASAGFYYVDRNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTPGEENADPTETVVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQRQILATGENYRTVNDIVSVLLNAEDERREEEKERQTEEMASGDLSLIRKNRMALFQQLTHVLPILDNLLEASVITKQEHDIIRQKTQIPLQARELIDTVLVKGNAAANIFKNSLKEIDSTLYENLFVEKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDREVSIVFIPCGHLVVCQECAPSLRKCPICRGTIKGTVRTFLS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis.  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.  The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1.  Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation.  Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.  Can stimulate the transcriptional activity of E2F1.  Plays a role in the modulation of the cell cycle.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 2, Cellular inhibitor of apoptosis 1, C-IAP1, Inhibitor of apoptosis protein 2, mIAP2, RING-type E3 ubiquitin transferase BIRC2.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity).
Protein: RL28_NITMU
Sequence: MARVCEVTGKKPMTGHHVSHANNKTKRRFLPNLQRRRFWVESERRWISLRLSNEALRTIDKNGIDAVLAEMRARRDSI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SYM_STUS1
Sequence: MSEARQILVTSALPYANGSIHLGHMLEYIQTDMWVRFQKLRGNQCIYVCADDAHGSAIMLRAEKEGITPEQLIANVQAEHSADFADFLVNFDNFHSTHSPENRELAELIYTRLRDAGHIATRSVTQYFDPEKGMFLADRFIKGTCPRCAAEDQYGDNCEKCGATYEPTELKDPRSAISGATPVLKDSKHFFFKLPDFEAMLKEWTRGGALQESVANKIAEWLDGGLQEWDISRDAPYFGFEIPGEPGKYFYVWLDAPIGYMASFQNLCKRRPELSFDAFWSKESSAELYHFIGKDIINFHTLFWPAMLEGAGFRKPTAVNVHGYLTVNGQKMSKSRGTFIKARTYLDHLNPEYLRYYYASKLGRGVDDLDLNLDDFVQKVNSDLVGKVVNIASRCAGFIHKGNDGVMVEANPEPELWAAFQAAAPSIADAYEARDFARAMREIMALADRANAWIADKAPWALNKVEGKQAEVQEICALGVNLFRQLVIFLKPVLPNLAAAAEQFLNVAPLSWDDHATLLANHKLNAFTPLMTRIEPAKIDAMIEASKEDLAASEAAVPAGNGELAKAPLAAEINFDTFAAVDLRIALIEKAEFVEGADKLLRLTLNIGDATRNVFSGIKSAYPDPSKLEGRLTLYVANLAPRKMKFGMSEGMVLAAGPGGSEIYLLSPDNGAKPGQRVM
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
Protein: ATPG_UREP2
Sequence: MSLDAMKRKINSVQTTAKITNAMKLVATAKLKRQRDRLAAIKEYCHDYYDVIGLLLSVVDDVEFLKIPNAKDRTLYITINSTMGLAGSYNYNVNKLISKIVNETDITFTIGKKGHDFMRLSGRVDQVNTYLNLNDNDLTFDMSLQIAREALELYSQGEVNKICIIYTKFINAITFEVSVIDVLPFDKTALIKDHLAETIELAKDNIIFKPNKFELVKKILPTYIATVLYGSLIESKISENASRRNAMDAATKNAKALAENYKLIYNTLRQGKITREITEIVAGSDD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UREF_XANP2
Sequence: MQGRAGAGEAAGAGSEADAPVSLLPLFAWLTPSFPVGAYAYSHTLEWAVEAGDIRDEESLGTFLGDLLALGFGRSDAILAAHAHRAAAVGDKTALAEVNALAVALAPSAELRLETCQQGRSFLDAVRAAWPAPGLDAAAAALVGEVAYPVAVGLAAGVHGLPLAPTLEAFLLATVQNLVSAAVRLAPIGQTAGTRVVARLAPGVRALALEIPTLTLDDLGSATFRADLGSFRHETQYTRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBPA_ECO5E
Sequence: MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_ZYMMO
Sequence: MVLADGQMIWGRGFGATGAKVGEVCFHTAMTGYEEIMTDPSFASQIINFTFPHIGNVGANREDVEAKTLHALGCIVREDVTAPSNFRSLWRFDSWLKDHDRIGLAGVDTRALTGLLRKKGAQNAVIAHDPKGQFDIPALIETARSWAGLQGMDLARSVSTHQSYNWQEGIWSLQNGYSVVDNQKGPHVVAIDYGLKHNILRNLVEAGARVTVVKATASFDEVMAHKPDGVFLSNGPGDPAATAEYAVPVIRQLLDIKMPIFGICLGHQLLALAVGATTYKMHQGHRGANHPVKRLDDSKVEITSMNHGFAVATDSLPEQARPTHLSLFDGSLAGLELTDRPAFSVQYHPEASPGPQDSYYLFTKFIDLIAKERP
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: TRHO_STRA3
Sequence: MSEKIRVLLYYKYVSIENAEEYAAKHLEFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLEDNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCANPFCNKQIFASEENEAKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPQVANV
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: SMA10_CAEEL
Sequence: MIVYSLLLLILYDFLPKVVTFDTVCIGLCHCVGNVVDCSSLDLSEIPTTIPNNTRILLLSDNEIESIDKSRLKGFYFLQTLDISNNIIRHIDFEFFYNLPNLKILNIRKNRLARIPRGSHELGHLEKLDLRSNLISTVTSEELSYLAAVRSVDLSRNLISYLPKPTTSAKVNIEKLDLASNSITDIGTDHFSSFNTLVTLKLARNHITTLNQFSFSRLRKLESLDLTRNMIREVRFLAFNQLPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLDLSYNQIQSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDSLHKFALVGMSSLHKLDLSSNTLAVCVEDGAVLYNTSMPFLRSLRFTNNQLRVIPKRAFERFPALEELDLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIAKCSYPPPLADLYVVAIDTANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAELLLDNVAMTDNSEYQCVARNRFGSDFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGTPRPEIKWAFEQIPFPAAEARRLYVTPNDDHIYIMNVTKEDQGAYTCHATNVAGQTQASANLIVFENFFHYPESPDLSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVILFLKKAKFSDNDQILTLTQTTFSDSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKSTGNGIYLMASCSAFGLMILGVITSICICIAKCSCNQNHVFNVLPVQV
What is the function of this protein?
Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro.  Has a role in regulation of body size.
What are the official names of this protein?
Leucine-rich repeats and immunoglobulin-like domains protein sma-10.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane; Lipid-anchor, GPI-anchor.
Protein: VGRG1_AERHY
Sequence: MADSTGLQFTVKVGALPENTFVVAEFALDEALNRPFNLRLELASAQPDIDFGAVLDQPCELLVWYNGELQRRVCGVVSDFAQGDSGFRRTRYQLRVLPALWRLSLRQNSRIFQAQKPDEILSILLQEHGITDYAFALKNEHAKREYCVQYRESDLDFVNRLAAEEGMFYFHEFEAGKHRIVFADDAAALTQGPELFFNLGNRSLEQGPYVRQFHYREAVRPSDVELKDYSFKTPAYGLSHKKVGAELTHQRDTYQHFDFPGRYKEDPSGKAFAQHRLDALRNDAVAGQAKSNCAALLPGQSFSLTEHPNGSLNTDWQIVRIQHTGLQPQALEEEGGSGPTVYHNEFGVVKASTTWRARIGSPEAPHKPMVDGPQIAIVVGPDGEEIYCDEHGRVKLQFPWDRYGSSNDQSSCWVRVSQGWAGGQYGMMAIPRIGHEVIVSFLEGDPDQPIVTGRTYHATNRPPYELPANKTRTVLRTETHQGEGFNELRFEDQVGQEEIYIHGQKDLNVLIENDAAWHIKHDEHTDVDNERVTRIKANDHLTVEGEKRDQIKADYSLTVDTSMHQKLGDSWLTQAGQEVHVKAGAKVVLEAGSEITVKVGGCFIKVDGGGVTLVGPTIKMNSGGSPSSGSGWGGKSPVDPLGVSVPPKPKVPLTPAQLATMKSAAPFCEECEKCKEGGCEI
What is the function of this protein?
Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection.  Acts directly as an secreted effector with an actin ADP-ribosyltransferase activity that disrupts the host actin cytoskeleton, leading to a decrease in host cell viability and an increase in apoptosis.
What are the official names of this protein?
Type VI secretion system spike protein VgrG1, Actin ADP-ribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: METXA_MYCUA
Sequence: MTISDVPTQTLPAEGEVRLVDIGSLRLESGAVIDNVCIALQRWGELSPTRDNVVMVLHALTGDSHVTGPAGPGHSTPGWWDGMVGPGAPIDTNRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISVRDQVEADMAALAALGITQVAAVVGGSMGGARALEWIVGHPDRVRSALLLAVGARATADQIGTQTTQIAAIKADPNWRNGDYHETGCRPEAGLKVARRFAHLTYRGEIELDSRFANDGQGGEDPADGGRYAIQSYLEHQGDKLLARFDAGSYVILTEALSRHDVGRGRDGIHAALRGCPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLEVVDSIRGHDGFLVESEAVGELIHKTLRLAEDRSSRPW
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_PSEAE
Sequence: MARVKRGVIARRRHKKILKLAKGYYGARSRVFRVAKQAVIKAGQYAYRDRRQRKRQFRALWIARINAGARQNGLSYSRLIAGLKKAAIEIDRKVLADLAVNEKAAFTAIVEKAKASLA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: YTHD1_HUMAN
Sequence: MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYYPPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVESHPVLEKLKAAHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVRKERQSRNKQ
What is the function of this protein?
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:32492408, PubMed:26318451).  M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408).  Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408).  The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408).  Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity).  Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity).  Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity).  In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity).  Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507).  The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544).
What are the official names of this protein?
YTH domain-containing family protein 1, DF1, Dermatomyositis associated with cancer putative autoantigen 1, DACA-1.
What is the protein family that this protein belongs to?
Belongs to the YTHDF family. YTHDF1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule.
Protein: RS13_BUCCC
Sequence: MTRIAGINISDKKHILVALTSIYGIGISLSKKICFSIGIRCDVKINSLTKEKIESLRSIISKFLVEGDLRREKTINIKRLMDIGCYRGLRHRKHLPVRGQRTKTNARTRKGPRKLIKSR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ATP6_BRUSI
Sequence: MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSKGMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMYINDAVHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MU110_SCHPO
Sequence: MVESSDENDQASSFASTEDLKELRFVFWFSVLIPIFFIALIIIKRYHSCTYQKNRLLRSIFCCMSIDDEEELETDMYDLPIVEPSITLPKYSASLQENERLVGIEGEREGIDVVLNFSKAGEGGVNPYPSFDTPNARILQLRQLAKLKKHGPRISYHGIGIGRCNGNRVLPPYPEPALLPEAPNTREASNNTYLYGFSNNFINISRTLNLRYPSASASISDSLPPPYQVLSVPSVTSTHAFSNNANQT
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 110 protein.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein. Note=Localizes to the barrier septum and cell tip.