PharMolix/UniProtQA huggingface dataset:
Protein: AT222_ASPFU
Sequence: MAFNSTPPVSPGGEAQQRPPRFPGEDTTPTSQKEIWGWYAYGIAAEVFAVCGVGSFLPLTLEQLAREHGTLLSSHLPCVRFSSPSTAPGNGTTTATFRRDGTDNDQCVVSVLGLQVNTASFAMYTFSLAVLVQALTLISFSALADYENNRKTLLLAFGFIGSMTSMLFIFIAPPVYILASLLVVVGVTCLGSSFVVLNSFLPVLVANDPSIQTAHKEQGEELSPVNSNGEFVRFEDLDEEISRDSDDHFTTGHRPKTKAAGSASPELQLSTRISSKGVGLGYCAAVLVQILSILMLFALSKTSLPKISGTLPLRFVLLLVGIWWFSFTMVSRRWLRDRPGPPLASSKGAARNSRWRIWLRLIGFAWKSLWKTAKVAVKLREVIIFLIAWFLLSDAMATVSGTAILFARTELKMSTTAVGLLSITATLSGMAGAFLWPVVSRRLRLKSNHTIMLCIALFEVIPLYGMLAYIPLFKKWGVVGLQQPWEIFPLGIVHGLVSGGLSSYCRSFFGLLIPPGSEAAFYALYAATDKGSSFIGPAIVGMLIDATGQVRSGFFFIAVLILLPIPLIWMVNAEKGRQDGLAMADILEKSHREHASEYGGPSEEAEGLLARDI
What is the function of this protein?
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation.  The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
What are the official names of this protein?
Autophagy-related protein 22-2.
What is the protein family that this protein belongs to?
Belongs to the ATG22 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Protein: YIDD_CHESB
Sequence: MALPAGYSRNWSGPWPKTPGRVLGTAFVRLYQLTLSGFIGNSCRHFPTCSEYAYEAIARHGLWAGGWMGLFRVMHCGPGGTHGIDPVPEILQPRHAWWAPWRLWKLKP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL13_YERPP
Sequence: MKTFTAKPETVKRDWYVVDASGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNAEKVAVTGNKRTDKIYYHHTGFVGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGTEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: MIAB_PARXL
Sequence: MTKKVYVKTFGCQMNEYDSDKMVDVLGAAEGLVKTDTPEDADVILFNTCSVREKAQEKVFSDLGRVRELKEANPNLIIGVGGCVASQEGASIVARAPYVDLVFGPQTLHRLPQMIDKRRESGRAQVDISFPEIEKFDHLPPARVDGPSAFVSIMEGCSKYCSYCVVPYTRGEEVSRPLDDVLTEIAGLADQGVREVTLLGQNVNAYRAGLTLGSTEIADFAQLIEYVADIPGIERIRYTTSHPKEFTQRLIDTYAKVPKLVSHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPDLSLSTDLIVGFPGETEEDFDKMMTLVHEMKYDTSFSFIYSPRPGTPAANLHDDTPREVKLRRLQHLQATIEENVQRISDSMVGKIERILVERPARKDPNELAGRTENNRVVNFPAPVASHARLIGQMVDVKIVKAYPHSLRGELVLVHDEAPATTH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_PELPB
Sequence: MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFLDESTTQSSNLTMGRVYKSVIDKERRGEYLGATVQVVPHVIDEIKDRMAEQAKNGDLDVLITEIGGTIGDIESLPFLEAMRQMKLEMGDSNLLNIHLTFVPYIKAASELKTKPTQHSVKMLLGVGIQPDILVCRSEKPLSREIKNKVGHFCNVNELDVIGLNDCDTIYEVPLMLLKEKLDLRVLKKLGLKKYKEPTLDYWRDFCNKVKFPQDGEVTIGICGKYTEYPDAYKSIIESFIHAGASNNVKVNVKLLRAEDAELNAFDFAKELEGINGILVAPGFGDRGIEGKIKYIQYAREHNVPFLGICLGMQCASIEFARNVCGLQDANSTEFNKRTRFPVIDLMAHQKKVKEKGGTMRLGSYPCIISEGSKAYAVYHKFLINERHRHRYEFNNAYRKNFEESGMVFSGTSPNGELVEIIELKNHRWFVAVQFHPELKSRVQKVHPVFHGFVAAAKEYAHGVHQMDLVVEMPSLVPVLTEPTQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RL15_MESFL
Sequence: MKLHELKYTEGSKKDVTRVGRGMASGKGKTSTRGHKGQNSRSGGGVRVGFEGGQTPLYRRLPKIGFTSPNQKEYVILNLSDLERLNLALIDHKVLVEQKIIKNEKQLVKVLGKGSITSAINVKLNKVSKSAQAEIEKLGGKVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ACT2_XENTR
Sequence: MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility.
What are the official names of this protein?
Actin, alpha cardiac muscle 2, Actin alpha 2, alpha2T.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL18_STRZP
Sequence: MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQVIDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHGRVKALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CCME_ECOLC
Sequence: MNIRRKNRLWIACAVLAGLALTIGLVLYALRSNIDLFYTPGEILYGKRETQQMPEVGQRLRVGGMVMPGSVQRDPNSLKVTFTIYDAEGSVDVSYEGILPDLFREGQGVVVQGELEKGNHILAKEVLAKHDENYTPPEVEKAMEANHRRPASVYKDPAS
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NUOD_FRATM
Sequence: MAEYKNYTLNFGPVHPAAHGVLRLILELDGENVVRADPHVGLLHRGTEKLAEFKPYNQSIGYMDRLDYVSMMCNEHAYVMAIEKLLQLEVPERAKYIRVMFAEMTRILNHLLWVAACGIDLGAMTVFLYAFRVREDLFDCYEAVSGARMHAAYFRPGGVARDLPTQMPQYQKTRFTSKRKAKKLNEPRQGSMLDFLDHFVVDFEKSLDEIDTLLTDNRLWKQRTVDIGTVTAERAKELGFTGPMLRGSGVAWDLRKTQPYEVYHKLEFDIPIGANGDCYDRYLVRMAEMRESNKLIKQCVDWLRANPGPVLSDNHKVAPPKRNAMKNNMEELIHHFKLFSEGYCTTEGEVYVGTEHPKGEFGVYIKSDGANKPYRLKMRAPGFAHISAMDELLSGHMLADTPAIISTIDVVFGDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YJAV_BACSU
Sequence: MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYLEERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKREKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTEKTSKEEAKTKIIEWKRQFSSIFDKY
What are the official names of this protein?
Uncharacterized protein YjaV.
Protein: SECA_PEA
Sequence: MATSSLCSSFTSQTCNPHSRPHRKTLTLPGSVFLCRQFHLNSPSVSKTRRIRTRQSGPVASLGGLLGGIFKGTDTGEATRKQYAAIVNTINGLEPKISALSDSELRDMTFASRERAQKGESLDSLLPEAFAVVREASKRVLGLRPFDVQLIGGMVLHKGEIAEMRTGEGKTLVAILPAYLNALVGKGVHVVTVNDYLARRDCEWVGQVPRFLGMKVGLIQQNMTSEQKKENYLCDITYVTNSELGFDFLRDNLATSVEELVIRGFNYCVIDEVDSILIDEARTPLIISGPAEKSSDQYFKAAKIADAFERDIHYTVDEKQKSVLLSEQGYEDAEEILAVKDLYDPREQWASFVINAIKAKELFLRDVNYIIRGKEVLIVDEFTGRVMQGRRWSDGLHQAVEAKEGLPIQNETVTLASISYQNFFLQFPKLCGMTGTAATEITEFESIYKLKVTIVPTNKPMIRKDESDVVFRATTGKWRAVVVEISRMNKTGRPVLVGTTSVEQSDSLSQQLKEAGILHEVLNAKPENVEREAEIVAQSGRLGAVTIATNMAGRGTDIILGGNAEFMARLKLREIMMPRVVKLVAEGEFVSVKKPPPSKTWKVNEKLFPCQLSNQNTELAEKAVQLAVKTWGKRSLTELEAEERLSYSCEKGPAQDEVIAELRNAFLEISKEYKVFTEEERKKVVAAGGLHVVGTERHESRRIDNQLRGRSGRQGDLGSSRFFLSLEDNIFRIFGGDRIQGLMRAFRVEDLPIESQMLTKALDEAQKKVENYFFDIRKQLFEYDEVLNSQRDRVYTERRRALQSVNLQSLLIEYAELTIDDILEANIGSDAPKESWDLDKLIAKIQQYCYLLTDLTPDLLLNECSDYEGLRSYLRLRGKEAYLQKRDIVEQQAPGLMKEAERFLILSNIDRLWKEHLQALKFVQQAVGLRGYAQRDPLIEYKLEGYNLFLEMMAQIRRNVIYSIYQFKPVLLKQDQDKMENQKSGKRNARPPTDTNPDPVGTVEPSTSASS
What is the function of this protein?
Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane (PubMed:7758587, PubMed:7989297, PubMed:9342223).  Facilitates the transport of precursor proteins from the chloroplast stroma to thylakoid lumen (PubMed:7758587, PubMed:7989297, PubMed:9342223).
What are the official names of this protein?
Protein translocase subunit SecA, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. Note=A minor fraction is associated with the chloroplast thylakoid membrane.
Protein: KYNU2_NEUCR
Sequence: MSTAAVQDARKQAEALDNEDSIAFVRDEFNIPTKAQIASSRLADSHPAALPASEDDAKCIYLCGNSLGVQPKRTVTRLNQYLTTWATQGVQGHFKPLEESPLPTWLDADAKAAELIAPVVGANVSEVAVMQTLTANIHLLMSAFYRPDINGRHKIILENKAFPSDHFAVETQIRHHSLSTEKSMVLIESSSKDNIISTEEVLSVISAHADTTALLLLPGIQYYTGQLLDIPAITAFAHKHGIFVIWDLAHAVGNVPLYLHDWGVDAAAWCSYKYLNGGPGCIGGLFVHTNNSVVTKEITDEKPEEGYNNRLAGWWGNDKKTRFVMANKFHPVAGAAGFQLSNPSILDITSLSASLEIFQEAGGMEALRSKSLKLTSFLEATLGHMKEEDRAHFRIITPSKSEERGAQLSLMLSDGLLDTVMKELEARGVIVDERKPNVIRVAPAPLYNTFKDCVLFVEAFSAALEVAKQHAL
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase 2, Biosynthesis of nicotinic acid protein 5-2, L-kynurenine hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_LEGPL
Sequence: MAVYSTNEFKNGLKVMVDDAPCSILDCEFVKPGKGQAFTRIKIRNLKTGRVVERTFKSGDTLPSADVADVEMQYLYNDGEHWHFMVPDTFEQYAVTENILADAAQWLKEQDVCVVTLWNNEPIQVTPPNFVILAITETDPGLKGDTSGGGGKPATLETGAVVRVPLFVQTGELIKVDTRKGEYVSRAKE
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_SYMTH
Sequence: MPIVFEAVSHIYQPGTPFAWKALDDVSLTIPDGEFWGIIGPTGSGKSTLIQHMNGLLRPTTGRVLVDGLDLSDRKTDLRKVRQRVGLVFQYPEHQLFGETIFEDVAFGPRNMQLGAAEVERRVMTALERVGLDPAMKDRSPFGLSGGQARRVALAGVLAMEPRVLILDEPTAGLDPQGRREILDLVGGFARTGMTVVLVSHSMDDVAEYADRVLVMHRGRVHMLGTPWELFARRAELEAIGLGVPAAVALADKLRERGWSIPPDVVTMDEAVAAIRGVLAGRKGADRP
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ACDH2_MYCMM
Sequence: MPSKASVAIVGSGNISTDLLYKLLRSDWLEPRWMVGIDPQSEGLARARKLGLETTHEGVDWLLAQSDKPDLVFEATSAYVHKAAAPKYAAAGIRAIDLTPAAVGPAVVPPANLREHLDAPNVNMITCGGQATIPIVYAVSRAVADLGGVPYAEIVASVASVSAGPGTRANIDEFTKTTSKGVETIGGARRGKAIIILNPADPPMIMRDTIFCAIPEDADRDAIAASIHEVVAQVQTYVPGYRLLNEPQFDEPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAMQTLAVSGGKR
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: F16PA_NOSP7
Sequence: MAKTPESLESSINEITDRALDRDCTTLSRHVLQQLQSFSPDAQDLSALMNRIALAGKLVARRMSRAGLMEGVLGFTGEVNVQGESVKKMDVYANDVFISVFKQSGLVCRLASEEMENPYYIPENCPIGRYTLLYDPIDGSSNTDNNLSLGSIFAIRQQEGTDSDGKATDLLANGRKQLAAGYILYGPCTMLVYTIGKGVHSFVLDPSLGEFILTEENIRIPNHGSVYSVNEGNFWQWEESIREYIRYVHRTEGYSARYSGAMVSDIHRILVQGGVFLYPGTIQNPEGKLRLLYETAPLAFLIEQAGGRATTGLVNILDVVPKKLHQRTPLIIGSKEDVAKVESFIQNGH
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BASS6_ARATH
Sequence: MSVITTPIETLHLKSTLRLLPRAVYRSQRIQVFPPNIFSNTSLSSPLRIDPISQVGGSRNLWRRYASDNFSEMGLDPGADPFKVIEKPSIVDRMKKANSILPHVVLASTILALIYPPSFTWFTSRYFVPALGFLMFAVGINSNEKDFLEAFKRPKAILLGYVGQYLVKPVLGFIFGLAAVSLFQLPTPIGAGIMLVSCVSGAQLSNYATFLTDPALAPLSIVMTSLSTATAVLVTPMLSLLLIGKKLPVDVKGMISSILQVVIAPIAAGLLLNKLFPKVSNAIRPFLPILSVLDTACCVGAPLALNINSVMSPFGATILLLVTMFHLSAFLAGYFLTGSVFRNAPDAKAMQRTLSYETGMQSSLLALALATKFFQDPLVGIPPAISTVVMSLMGFTLVLIWSKEKSNTF
What is the function of this protein?
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
What are the official names of this protein?
Probable sodium/metabolite cotransporter BASS6, chloroplastic, Bile acid transporter 4, Bile acid-sodium symporter family protein 6.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Plastid, chloroplast envelope.
Protein: NPRL2_MOUSE
Sequence: MGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSNEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFSSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVSREERSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK
What is the function of this protein?
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling.  Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues.  May act as a tumor suppressor.  Suppresses cell growth and enhances sensitivity to various anticancer drugs.
What are the official names of this protein?
GATOR complex protein NPRL2, Gene 21 protein, G21 protein, Nitrogen permease regulator 2-like protein, NPR2-like protein.
What is the protein family that this protein belongs to?
Belongs to the NPR2 family.
What are the subcellular locations of this protein?
Lysosome membrane. Note=Localization to lysosomes is amino acid-independent.
Protein: PDXJ_DESVM
Sequence: MPVLVVNVDHVATLRQQRKGKEPDPLTAAHLVELAGARGIIVHLREDRRHIQDHDVELMARTLKTRLHLEMAATEEMQAIALARQPYMVCLVPEKREELTTEGGLAVAGREAFLKDYLAPIHARGILSSLFIEADEAQVRAAAAIGCPYIELHTGHFADAPTRAAQRAERDKIVRAIGLARSLGLGVNLGHGLNYDNIYEFADVPGISEFSIGHSIVARAVFTGFERAVADMAAIIARFPA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBEAG_HBVC1
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWLRGMDIDTYKEFGASVELLSFLPSDFFPSIRDLLDTAFALHREALESPEHCSPHHTALRQAIVCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSVGVWIRTPQAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSKSPRRRRSQSRESQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: IRX9H_ARATH
Sequence: MASIRRTLSPMYHDRSHENGGSHKGFTIGGSSSKHNSSQFLSYLTKLLGVTSDPKSSRRGPWRRPFYQFLVFFLLGFVLGLTPFGKMEDVNGSDRFSFEIKQPYVEERLENRKREEAAVDAVSFVAETENGKKEVNFVPKKLLIVVTPTYNRAMQAYYLNRVAQTLRLVESPVLWIVVEGNVASFETSEILRKTGVMYRHLVCKRNMTSIKDRGVHQRNTALEHIELHKLDGIVYFADDDNIYSLELFQSLRQISRFGTWPVAMLAQSKNKAILEGPVCNGSQVIGWHTNEKSKRLRRFHVDMSGFAFNSTILWDPKRWRRPFSHPTRQLDTVKEGFQETSFIEQVVADESEMEGVPPACSSILNWHLHLDALDVPYPQGWAIQKNLQALITMK
What is the function of this protein?
Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls.  Probably involved in the elongation of glucuronoxylan xylosyl backbone.
What are the official names of this protein?
Probable beta-1,4-xylosyltransferase IRX9H, Protein IRREGULAR XYLEM 9 homolog, Xylan xylosyltransferase IRX9H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 43 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: TSAD_STAS1
Sequence: MSETTLILAIESSCDETSVSIIENGKNILSNIVLSQIESHKRFGGVVPEVASRHHVEGITTTIDEALNSANTTMNDIDAVAVTQGPGLIGALLVGINAAKALAFAYDKPLIPVHHIAGHVYANHLEKPLQFPLIALIVSGGHTELVYMKNHLSFEVIGETRDDAVGEAYDKVARTIGLSYPGGPQVDNLAAHGEDSYDFPRVWLDKNSYDFSFSGLKSAVINKLHNLRQKGEAINEANVATSFQNSVVEVLVGKTIAACKNYNVNQLIVAGGVASNKGLRAHLSSACESNDINLSIPSPKLCTDNAAMIGAAGYYLFKAGVTADMALNGYNHMDIEQCSIES
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_METBU
Sequence: MNEKHLTYADSGVDIEKEESTIKALTNGMTYKREGIGAPLTSIGHYAGLIDFGEYALAMATDGVGSKVLIANEMKRWNTVGIDCIAMNVNDLLAIGAEPISFVDYLALEKHSDDFASQIGEGLVKGAEISRMSIVGGETATLPEIVNGFDLAGTCLGMVKKEEVITGEKVRLGDVLVGIPSNGVHSNGYTLVRDIIKESGHSYHEDFSYNTETTIGDELLIPTRIYMEVLDVIKECDVHGLAHITGSGLLKLKRVTGLGFDFTDPIEPGNIFKFLQEEGNVDDLEMYRTFNMGMGFLIILPEADAEKAAEMTGGKIVGKIVESGIRVRDLEIV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATZ_ECOSM
Sequence: MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTGMTPADFREFVFAIANKVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKAYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCLAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITQVEDAANTLRTHQKAFIARGLAEALTRVIAIVVQPGVEFDHSNIIHYQAQEAQALAQWIEKTKMVYEAHSTDYQTQAAYRELVRDHFAILKVGPALTFALREAVFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRTGFHDSLLDIRYSLSDRIRYYWPHSRIKNSVETMMVNLEGVDIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGCAE
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of GatY.  When expressed alone, GatZ does not show any aldolase activity.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. GatZ subfamily.
Protein: NNRE_RAT
Sequence: MSGLRTLLGLGLLVAGSRLPRIASRQSVCRAGPIWWGTQHRSSETMASAAVKYLSQEEAQAVDEELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSKSPPTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFLGEMPPEPMMVDELYELVVDAIFGFSFKGDVREPFHSILSVLSGLTVPIASIDIPSGWDVEKGNPSGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPAYPDTECVYRLQ
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.  Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
What are the official names of this protein?
NAD(P)H-hydrate epimerase, Apolipoprotein A-I-binding protein, AI-BP, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
What are the subcellular locations of this protein?
Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation.
Protein: IBP2_CHICK
Sequence: MALGGVGRGGAARAAWPRLLLAALAPALALAGPALPEVLFRCPPCTAERLAACSPAARPPCPELVREPGCGCCPVCARLEDEACGVYTPRCAAGLRCYPDPGAELPPQALVQGQGTCARPPDTDEYGASTEPPADNGDDRSESILAENHVDSTGGMMSGASSRKPLKTGMKEMPVMREKVNEQQRQMGKVGKAHHNHEDSKKSRMPTGRTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSVNGQRGECWCVDPIHGKVIQGAPTIRGDPECHLFYTAHEQEDRGAHALRSQ
What is the function of this protein?
Inhibits IGF-mediated growth and developmental rates (By similarity).  IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2.
What are the subcellular locations of this protein?
Secreted.