PharMolix/UniProtQA huggingface dataset:
Protein: P53_MARMO
Sequence: MEEAQSDLSIEPPLSQETFSDLWNLLPENNVLSPVLSPPMDDLLLSSEDVENWFDKGPDEALQMSAAPAPKAPTPAASTLAAPSPATSWPLSSSVPSQNTYPGVYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSECTTIHYNYMCNSSCMGGMNRRPILTIITLEGSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKRGEPCPEPPPRSTKRALPNGTSSSPQPKKKPLDGEYFTLKIRGRARFEMFQELNEALELKDAQAEKEPGESRPHPSYLKSKKGQSTSRHKKIIFKREGPDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: LEPA_ANAD2
Sequence: MAEKNSHIRNFSIIAHIDHGKSTLADRLLEHTGTVTKREAQAQFLDNMELERERGITIKAQTVRMKYRAQDGRDYELNLIDTPGHVDFAYEVSRSMAACEGAILVVDATQGVEAQTLANVYQALDHDLEIVPVINKIDLPSADVEGVRQEIEEVIGLDAKDAVPASAKEGIGIGEILEQIVHRVPAPEGDPDAPLKAIVFDSWYDSYRGVVMLVRVFEGTVRPKQKIRLWSNRKEFEVQELGVFAPFAKAVVELQAGEVGVVVANVKDVHDAKVGDTITDATRPTEEPFPGFKVVKPMVFSGVFPIEAADYEQLRDALEKLSLNDSAFTYEPETSQALGFGFRCGYLGLLHMEIVQERLEREYQLALITTAPSVVYRVTDTSGAVEEIDNPAKLPPVQKIAKLEEPHLTCHIHARTEDVGAILKLCQERRGLQRDLKYLGTKRVQITYDIPLAEVVFDFFDKLKSVSRGYASLDYELKGYEEADLVKLDILINGEPVDALSVIVHRERAYQRGRDLCQRLREVIPKQMYEVAIQAAIGAKVIARETVKAFRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGSVEIPQEAFLAVLKVEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GPMA_SALNS
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGFSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNDTILPRMKSGERVIIAAHGNSLRALVKYLDNMSEDEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RNC_RICCK
Sequence: MSSFNELEKLLGYSFKNKELLIEALSHPSLRQHHEYKDNKDYERLEFLGDAVLNLVITKILFSNFASYNEGNLAKIRSYLVCKETICMVGAKLALKDYIIMTYGEEVAGGRDNPNNIENATEALIAAIYLDSNIETTHNIIGQLWAEFIKVQNLTDYDPKTALQEWAQASDHHLPIYCLIKREGAAHSSTFTVLVKVKDYEQIGIGYSIKEAEKNAARSLLHRLKND
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRY1_HUMAN
Sequence: MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
What is the function of this protein?
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec.  The single-chain form is more active than the two-chain form against all of these substrates.
What are the official names of this protein?
Serine protease 1, Anionic trypsin I, Anionic trypsin-I, Beta-trypsin, Cationic trypsinogen, Pretrypsinogen I, Trypsin I, Trypsin-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: COBD_THEVO
Sequence: MIVVLIGALSIDIIFGEPKEYIHPVVFSGRVASAIEGYFRKFDNRFRAGILFSIAVIVLTAIPYFLAVYLSSFILVVYVVVSMVILKTTFSITSMGEHIKLITDSLKKGNIMEARMHLSMIVRRDTSRLNENEISSAAIESIAEGLVDGYITPLFFFVFFGLPGAFIARIINTLDSMYGYKDRKNFEFGRFSAFMDTVINYIPARISWFFITFSSDILNYRSKAIPVRRYIRRFDSVNAGWPIASMASALNLRLEKKGHYIVNDDGYQPGVADIEKSMKIYYLAAYSYIVIFVLPLLVIMAVFL
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Probable cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUC15_MOUSE
Sequence: MLTLAKIALISSLFISLPFARPQKQNPRRNVTQHTIEDVKIMRNNSIHLERSINVTSENGSDISNLMVTTPSPLNLSTTFRTTNSTRTWLMTSSSESSRPSSTYSVPPLVQGFVSKLPLNSSTADANPLQVSEHSNSTNSPSPENFTWSLDNDTMNSPEDISTTVRPFPPPPKTTPVTPFTAEPTEWLPTNNDNFAGFTPYQEKTTLQPTLKFTNNSKLFPNTSDTPKENKNTGIVFGAILGAILGASLLSLVGYLLCGQRKTDSFSHRRLYDDRNEPVLRLDNAPEPYDVNFGNSSYYNPAVSDSSMPEGGESLQDGIPMDAIPPLRPSI
What are the official names of this protein?
Mucin-15, MUC-15.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NIFW_NOSS1
Sequence: MTKSLEEFKKLVDAEEYFKFFELDYDAKIVNVNRLHILKKFSQLISEIDTNYPDISAEEKLNQYSLALQSAYQVFLGSSPQEQKLFKVFKDKPKNVITLTELSSD
What is the function of this protein?
May protect the nitrogenase Fe-Mo protein from oxidative damage.
What are the official names of this protein?
Nitrogenase-stabilizing/protective protein NifW.
What is the protein family that this protein belongs to?
Belongs to the NifW family.
Protein: IRL34_CAEEL
Sequence: MQWPLIAALFTQLYHFVIGDDCYCPLCELDKLPDNCTTIHGHIQMGLESTMPPFEIVEYKLENVTKIVGCITIANSGFTSLSLLSNLEIVQYSQTGNSSTCSSYGNIITIAKNSLLRRLYLTSLKKVILSKKAEYGIYLLDNPSLCITEGELEQFMQTEKFHAPHIQICDPTKNYCRLDNFEFFNDKNIPVGCQVLTDSLVLNGTKEINGLEFQSRLNDIEQILGSITVFESEIASLKFPNLWRVYNFQPDLPVIFLQENGNLSEVEFSNLTSIPYFGNYPDVLYAFSNPLLTNLSLDTCENLNSLGPITFEEVSNSICENRTSSVVPNQDKNRTGNSGGLIVDVEVSGTNSTALSSVGKDGPPENNTKDNSVYRVFDFNLNLSFLFYLLIFQKLFI
What are the official names of this protein?
Protein irld-34.
Protein: RL1_BACP2
Sequence: MAKKGKKYVEAAKLIERTKAYDVAEAVSLTKKANTAKFDATVEVAFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADYVGDSDYITKIQQGWFEFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAINEIKAGKVEYRVDKAGNIHAPIGKVSFEDEKLVENFATIYDTILKAKPAAAKGVYVKNVSVTSTMGPGVKVDPSSFSAK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: METK_PSELT
Sequence: MKRLFTSESVTEGHPDKVADQISDAILDALIEQDPDARVAVETLVTTGLAVVAGEVTTEAYVDIQDIVRRTILDIGYTRAKYGFDGETCGVVTSIHSQSPDIALGVNKALEAKEKNDDGDEFDKIGAGDQGMMFGYATNETPEFMPLPIVLAHQLAMRLSKVRKEKIVPFLRPDGKTQVTVEYSDDGKPMRIDTILISAQHDPNVTINELKEVLLEHVIKPTIPEQYWSDNIKILVNPTGRFVLGGPSADTGLTGRKIIVDTYGGWVPHGGGAFSGKDPTKVDRSAHYMARYVAKNVVAAGLADRFMIQVAYAIGKARPVSLMIDTFSTSKVDEEKLKDVIIQLFDFRPLAIINKLNLQRPIYKKTAAYGHFGRNDPDFTWESLDAVEELKRAFNI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METJ_HAEDU
Sequence: MINWSGKYISPYAEHGKKSKQVKKITVSIPIKVLEILTNERTRRQINNLRHATNSELLCEAFLHAFTGQPLPADEDLMKERYDEIPEKAKSRMRDLGIDPDEWQY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4660_CUPPJ
Sequence: MMLQIPDVLSKAQVAQCRQMMDVADWTDGNATSGHQSALAKRNMQLPEGSPVARQIGDLIQDALGANATFFSAALPLKVFPPLFNRYEGGQAFDNHVDNAIRYLRGTGFRVRSDLSATLFLTEPQDYDGGELVIEDTYGQHRVKLPAGYMVLYPATSLHHVTPVTRGARVSSFFWIQSMVRDEGQRALLFELDTRIQQVAEEMGQKDSGVVGLTGVYHNLLRRWADA
What are the official names of this protein?
PKHD-type hydroxylase Reut_B4660.
Protein: KLH20_CHICK
Sequence: MDGKPMRRCTSTRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTSLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSTKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGYLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport.  The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.  It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity).
What are the official names of this protein?
Kelch-like protein 20.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus.
Protein: PA2A_BOTJA
Sequence: DLWQFGQMMNDVMREYVVFNYLYYGCYCGWGGIGKPRDATDRCCFVHDCCYGKVTGCNPKTDSYTYTYSEENGDVVCGGDDLCKKQICECDRVAATCFRDNKDTYDTKYWLYGAKNCQEESEPC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits collagen- and ADP-induced platelet aggregation.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2, svPLA2, BJ-PLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: H2B6_ORYSI
Sequence: MAPKAEKKPAAKKPAEEEPAAEKAEKAPAGKKPKAEKRLPAGKGEKGSGEGKKAGRKKGKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGESAKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.6.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PP271_ARATH
Sequence: MKRINVDLHLLHFPKFRKFQSRKVSSSLPKLELDQKSPQETVFLLGQVLDTYPDIRTLRTVHSRIILEDLRCNSSLGVKLMRAYASLKDVASARKVFDEIPERNVIIINVMIRSYVNNGFYGEGVKVFGTMCGCNVRPDHYTFPCVLKACSCSGTIVIGRKIHGSATKVGLSSTLFVGNGLVSMYGKCGFLSEARLVLDEMSRRDVVSWNSLVVGYAQNQRFDDALEVCREMESVKISHDAGTMASLLPAVSNTTTENVMYVKDMFFKMGKKSLVSWNVMIGVYMKNAMPVEAVELYSRMEADGFEPDAVSITSVLPACGDTSALSLGKKIHGYIERKKLIPNLLLENALIDMYAKCGCLEKARDVFENMKSRDVVSWTAMISAYGFSGRGCDAVALFSKLQDSGLVPDSIAFVTTLAACSHAGLLEEGRSCFKLMTDHYKITPRLEHLACMVDLLGRAGKVKEAYRFIQDMSMEPNERVWGALLGACRVHSDTDIGLLAADKLFQLAPEQSGYYVLLSNIYAKAGRWEEVTNIRNIMKSKGLKKNPGASNVEVNRIIHTFLVGDRSHPQSDEIYRELDVLVKKMKELGYVPDSESALHDVEEEDKETHLAVHSEKLAIVFALMNTKEEEEDSNNTIRITKNLRICGDCHVAAKLISQITSREIIIRDTNRFHVFRFGVCSCGDYW
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At3g49142.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: HGD_PSEPG
Sequence: MNRDTSPDLHYLSGFGNEFASEALPGALPVGQNSPQKAPYGLYAELLSGTAFTMARSELRRTWLYRIRPSALHPRFERLARQPLSGPLGGINPNRLRWSPQPIPAEPTDFIEGWLPMVANAAAEKPAGVSIYIYRANRSMERVFFNADGELLLVPEQGRLRIATELGVMEVEPLEIAVIPRGMKFRVELLDGQARGYIAENHGAPLRIPDLGPIGSNGLANPRDFLTPVAHYEEAEAPVQLVQKFLGEHWACELQHSPLDVVAWHGSNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANMDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLINGAYDAKAEGFLPGGASLHGVMSAHGPDAETCEKAIAADLAPHKIDNTMAFMFETSQVLRPSLQALECPQLQADYDSCWATLPSTFNPNRR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: TYSY_BRUSI
Sequence: MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXD_SHIBS
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSTLLAEALVLKLRKQSVAATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQVIFSGHTASGADMNTLHLGIDGISQATPLDTFKTSVRAGHSVEQIMQYPIYSGILAGAGWQWVNLAWLAGGLWLLWQKAIRWHIPLSFLVTLALCATLGWLFSPETLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YHBE_ECO57
Sequence: MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAMARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAGE
What are the official names of this protein?
Uncharacterized inner membrane transporter YhbE.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCPP_BPT4
Sequence: MNEPQLLIETWGQPGEIIDGVPMLESHDGKDLGLKPGLYIEGIFMQAEVVNRNKRLYPKRILEKAVKDYINEQVLTKQALGELNHPPRANVDPMQAAIIIEDMWWKGNDVYGRARVIEGDHGPGDKLAANIRAGWIPGVSSRGLGSLTDTNEGYRIVNEGFKLTVGVDAVWGPSAPDAWVTPKEITESQTAEADTSADDAYMALAEAMKKAL
What is the function of this protein?
The pathway of bacteriophage T4 head assembly begins with the formation of a prohead bound to the bacterial cell membrane which is later converted to the mature, DNA-containing head.  During maturation, all but one of the prohead proteins are proteolytically processed by a phage-coded protease which is formed by autocatalytic cleavage of the product of gene 21 (gp21).  Protease gp21 has been tentatively located in the center of the prohead core.
What are the official names of this protein?
Prohead core protein protease, Protein Gp21.
What is the protein family that this protein belongs to?
Belongs to the peptidase U9 family.
What are the subcellular locations of this protein?
Virion.
Protein: FOLD_ECOLI
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.  This enzyme is specific for NADP.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ATPB_HYDCU
Sequence: MNGKIVQIIGPVIDVEFKGADLPKIYDALKVDELDLTLEVQQQVGDNVVRAIAMGSSDGLKRGMAVSNTGEAISVPVGKPTLGRIFDVLGNPIDNAGPVESEEKMTIHRPAPAFDELAASQELLETGVKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYYEMEESGVLDKVALVYGQMNEPPGNRLRVALTGLTMAEYFRDEGRDILFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLSQEMGQIQERITSTKTGSITSIQAVYVPADDLTDPAPATTFAHLDATVVLNRSIAETGIYPAIDPLDSTSRQLDPLVVGSEHYDTARGVQETLQRYKELKDIIAILGMDELSEEDRSLVARARKMQRFFSQPYFVAKVFTGEDGRYVPLKETLRGFKMIISGELDDIPEQAFMYAGDIDEVLEKAKKYKD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYP_LEPBP
Sequence: MKASSYLIPTAKEDPQDAVVASHKLMMRAGLIRKSAAGLYSYLPLGLRVLRKIEGIVRKEMDKAGGLEFQLPILTPSEIWKESGRWDKMGKEMFRLKDRHDNESCLGPTHEESFCVLVKPMVRSYKDLPINVYQIHTKFRDEIRPRFGVIRSREFTMKDAYSFHLDDESLDKTYQTMRKTYRRIFAGMGLTTIPVQADSGNMGGSASEEFMVVSPIGEETLTICPSCHYSGNIEKTPVIVNRNATKQVFDGKGKLHTPAKKSITEVAEFLNTKEENLLKAVAVVADGQYILVFLEGDRELNENKLKNHLGCNELRPMGPAEMEKLGLVPGFIGPGFPKSESLKIYIDALLDWNFSYIAGGNEIDHHIAGVQLTSIFKEEEVTKIDISQAKVGDPCPSCGTGLTAEKGIEVGHIFKLGQKYSKAFDITVLNDKGKATTTTMGCYGIGVNRCMATVIEQCNDEKGIFWPVSIAPFTVCLVSIAKNPDDIAKIETIYKSLVESGIEVLWDDRDLGPGFKFKDSELIGFPIRITLGKGFLEKNEITILDRKSMAEDTLVYTTNEELVTHLKLKISQLEETIEKEVSLAGT
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_TROWT
Sequence: MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKSAQDSGFEVLLPQEAAKKAQLISLLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKDASGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLIIDLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQDSGANEFTQLREIAARHPIEEVGARLRALFSWSK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL29_THEPX
Sequence: MKAREIRELTNEELLQKLSDLKAELFNLRFQLATGQLDNPMRIRDVRKTIARIKTILRERELGIRQNKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.