PharMolix/UniProtQA huggingface dataset:
Protein: MTRA2_METTM
Sequence: MVDKKVDKKPVPEDWPHIVGDYVVGDAESPVAVVTLGSHMEDEPVRAGAAISGPLHTENLGIEKVVGNVIANPNLRFLLVCGAEVMGHITGQTMKALHSNGVDGETGRIIGATGAIPYIENMPDEAIERFRRQVELVDMVDVEDPAAIRERIGECVVHDSGAIDEEPLILRPSEDLNKNKPDENT
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit A 2, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 2.
What is the protein family that this protein belongs to?
Belongs to the MtrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MRNC_SYMTH
Sequence: MRLANPLTLPPLTLAYLGDALYEAFVRERLLERGYVRVNDLHRHALRYVQATAQAAILHHLMPALTEQEQDVVRRGRNAKGHGAPKSADPAEYAASTGFEALVGYLYLAGQAERLSEVLQAAADFIERGQ
What is the function of this protein?
Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor.  Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.
What are the official names of this protein?
Mini-ribonuclease 3, Mini-3, Mini-RNase 3, Mini-RNase III, Mini-III.
What is the protein family that this protein belongs to?
Belongs to the MrnC RNase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STS1_YEASL
Sequence: MGFEWGFKPSSKITQSTVSSQGTGNVMIPTAGVKQKRRYANEEQEEEELPRNKNVMKYGGVSKRRPQPGSLIRGQPLPLQRGMELMNKNQLQQLLVDLMTKHPEIQQSVHTRVIGLDFSIQKCLDMLKQKSEAVYQSIPYNRSYESNKLDDYAFVRMKPQILEFLNCLVDFILDNIPPRLENLHASLKFLDICTELVIKLPRFELASNNYYYDKCIEQLSHVWCTLIEHXARDRIILLADNSSVWKSHMTRLQVYNEHSNGLLERPLQLFKSLDMGSPSAASSSTLSLQESIIYHHDTMTANENNNNSGSAATDSPFN
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1, Dumbbell former protein 8, SEC23 suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RECR_STRA5
Sequence: MLYPTPIAKLIDSFSKLPGIGTKTATRLAFYTIGMSDEDVNEFAKNLLAAKRELTYCSVCGNLTDDDPCLICTDKTRDQSVILVVEDSKDVSAMEKIQEYNGLYHVLHGLISPMNGISPDDINLKSLITRLMDGQVTEVIVATNATADGEATSMYISRVLKPAGIKVTRLARGLAVGSDIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RPOA_PHATC
Sequence: MNNISIKCLKSEKIQSGACHGQFLINSLNPGQGITIGNQLRRVLLGDLGGVAISAVRIAGITHEFSTIPGVREDILEILLNLKGIICTSQIQDTQFGHLKVQGPSVVTADLIQLPPGVEIINPNHYIATISTSNILEIEFKFEYGSGYHLASQNFVEEDENYLQLDTIFMPVQKVDFKIENIYDATNNISERLFLDIWTNGSISPNDALESAAQVIIDLFTLLINNKNINNNNRLELKPETISIEPYTNIAIEELQLSVRAYNCLKKAQINTVGDLLQYSPEKLQELKNFGRKSADEVFSTLKNKLGIILK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y2088_CLOBA
Sequence: MLVVISPAKTLDFNKINETLPMTNPKFLKEARVLVEELKNYDSYSLGKLMKTSDKLSLLNKNRFDIWNESFDNSRQCLIAFKGEVFKGIDVGSFNVEDLFYTNDHLRILSGLYGALNPFDGVNPYRLEMGTKLSFNNYKNLYDYWGDKLKYKIIEDIKSTGDNMLVNLASYEYFKSIEGIDLIDTSVNIVTPIFKEYRNGEYKIVTMKAKKARGLMVSFIMKNKINNIEDLKKFDLEGYLYNEDLSNNNELVFTLEN
What are the official names of this protein?
UPF0246 protein CLH_2088.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: SYA_CHLPM
Sequence: MKSSDIRQSFLDFFVGKSHAIVRSAPVIPADDPTLLFTNAGMNQFKDVFLAKGTRSYSRAADTQKCIRASGKHNDLEDVGRDTYHHTFFEMLGNWSFGDYYKEEAITWAWELLTVVWKLPEERLYATVYHDDDESFRIWEEKTSIRPDHILRFGDKDNFWEMGETGPCGPCSEIHIDLTPDGSGRALVNADDPQAIELWNLVFIQYDRQVDGRLEPLPQRHVDTGMGFERVCAVMQGKSSNYDTDVFRPLFDTITELTGVEYGASMHDPQDIAMRVIADHARTLSFALSDGAMPSNEGRGYVLRRILRRALRYAKDLGYNKPILHRLVATVADSMGDVFPELRDRQDAVARIVKAEEESFLVTLDRGIEIFNGLVGKVRGEGSSTLEGEDAFKLYDTYGFPFDLTRLMASSAGLQVDGEGFERCMQEQKTRARQDRREKQRGGAEEGSWEWFSDLHATEFTGYDGLEADASIIGISRSKKNLLLVLDRTPFYAESGGQTGDRGWIETGEYRLEVTDTQKDGDSFVHVVTRAFDNVRDSEADPADIAVGPGRVHASVDRKLRQATERNHTATHLLHAVLRHTLGAHVQQKGSLVNPERLRFDFSHFSKLTPEEIDAVESAVNDCIRQAEATLKHADVPYDDAITKGALAFFGDKYADLVRVVEIPGISVELCGGTHVDNVGQIGLFKIVGESSVAAGVRRIEALTGRAAEELMWNEYRELHDVRQLLKMKAEEPPAEKVAAILEERRALEKQLAELKAEVLLVKLQGDASALEDVCGCRIVARVVDGADAEGLRYAAQMLRQQFPLSAGLLCSSAEGKVSLAAFASDRAVKELGIDAGKLIRQAAAAVKGGGGGKAEFATAGGKNPEGMEDACRVFREAVRCIVKA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K0319_HUMAN
Sequence: MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
What is the function of this protein?
Involved in neuronal migration during development of the cerebral neocortex.  May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers.  May also regulate growth and differentiation of dendrites.
What are the official names of this protein?
Dyslexia-associated protein KIAA0319.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.
Protein: CP2C1_RABIT
Sequence: MDPVVVLGLCLSCLLLLSLWKQSYGGGKLPPGPTPFPILGNILQIGIQDISKSFTKLSEVYGPVFTVYLGMKPTVVIHGYDAVKEALVDLGEEFSGRIVFPLTAKINKGYGIVFSNGKRWKETRRFSLMTLRDFGMGKRSIEDRVQEEARCLVEELRKTNGSPCNPTFILGAAPCNVICSVIFQNRFDYTDQDFLSLMGKLNENFKILNSPWVQMCNNFPILIDYLPGSHNKILRNNIYIRNYVLEKIKEHQETLDINNPRDFIDCFLIKMEQEKDNQQSEFTIENLMTTLSDVFGAGTETTSTTLRYGLLLLMKHPEVIAKVQEEIERVIGRHRSPCMQDRSRMPYTDATVHEIQRYINLIPNNVPRATTCNVKFRSYLIPKGTAVITSLTSMLYNDKEFPNPDRFDPGHFLDASGKFRKSDYFMPFSTGKRVCVGEVLARMELFLFLTAILQNFTPKPLVDPKDIDTTPLVSGLGRVPPLYQLSFIPA
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2C1, CYPIIC1, Cytochrome P-450 IIC1, Cytochrome P450 PBc1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: SLAP1_THET8
Sequence: MKKRLVTLLAGLLTVLSMGFGLAQFSDVPAGHWAKEAVEALAAKGIILGFPDGTFRGNENLTRYQAALLIYRLLQQIEEELKTQGTSPTMEALAPEDLEALKNAVQELAAELASLGVRVSALEDSAATKEDIARLEAMIAELKAQPMPEPGMDQAALKDLMDRVEAASIAADTALAQAQQLAERLDALAQDVEGVKGDLAGLRSQVEANADAIQALNELAVLLNQDVLSLQDRVTALEKMVSGGQELPDLEQFATKEDVAAVQEFAAALRSDLVGLSDKVSKLEEQVAELNKVRYSISGSLSATYGTVVTDTGTNFDIDRLFPGNAFSTGTYGSFSSSVQAGDSNQGNISGGSASLTFGVKVAQPGTSGVNVSEASATLQVPAAFGTAYTSAPTIRLNAASVKGNVDGQAFSVVYSRAVSSFKFNDYLFANDNDSEPANPRQGMVATFSATKFPLAPEVTVVAGVAGPDATKDTAPALNGNYFGIRTAVKPFSALNLALNYATNLGNRSAIGVDGGLELGPAKLSGLWVSSQTPGSPFADFFDNTLSDWAYYAQAEAKLGPLSLSANYHAVDPQYADGQAGMSENEDTTYYGGEKAGAPYGADTRGLGVSASVGFGPVTLKGYAESEGDYNLAPGSVNDAWGVAATLGSFRGFSLTGFYNAAYTGGNGYFSLTTAVDAIAPGVTYYYTIENQKYSSSWGVRVAHDGKAEDALIPTLNLTAQYATYYVSGHTDIQVYADLAKPFKLAILSLSPGFRYHSFAGAGSAPTYTTLKGGVQVSTDPLLFGLSLDGAVSYRRTQYTNNPSNVTTYELYYRAGVKLQDFLAPKLNFSVAYAHYEGDQLAGTGLPVVGSGNQAFNFARDRVYRSPDPIAAPWLATPGTQAGKLDGFYIEAKYYDLTVAYGEFVLDDLNGTNPNFGRGFKISYTVKF
What is the function of this protein?
The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.
What are the official names of this protein?
S-layer protein, P100 protein, Surface layer protein.
What are the subcellular locations of this protein?
Secreted, cell wall, S-layer. Note=This bacterium is covered by a S-layer with hexagonal symmetry.
Protein: RPOB_MYCGE
Sequence: MSQKSNFFQKRYSPTATRRYYGKIETNFIQPNLADIQIKSYQKFLDHDLEKLIASYFPIKSPNDRYTINFRGLHRTEPERDEAQSRAQSKTYEVGIYADLELVDNDKGTVKKARKSKKNIASNTNGVFLASMPLITHDGVFIINGIEKFVISQITRSPGIYMLTKSQLKLSNSRKRVQEGYVCEVLPANGSVMLIYISNKKKIEDAFVQILLRDAVREGAKIFPITTLLKAFGLNNREILKIFKNNEFIKRSLEAEIYNAKDFLSNVDPEIKNLLKEFRDGKTDLRRKGIASDQKLRSLVNEYVTLEKQYNALKQTSPNDSSLTALELEMENKMDSVITERAAKHIVNELSISLRDIENTEECHEVSFHALLCARFFRNKRYNLSNAGRYKVSRKLRLTERIYQKTLACDLFLKDGKLLLKKGTLLLKEEIDKIKQAAKNNEISFVNKMQLTTDGKAVDLAKESLFYETIDVYITNDNLSVSVPVIGIHNENDLNKAMTLSDFIASISYVINLPYGIGKYDDIDHLGNKRVKLINELITAKLESGFTRMERFLKEKLTIADGVNRGQQINEEGQVIEQGEKKELTIKSLINSKPIQIVIKDFFNTHQLTQFLDHQNPLSELSNKRRISAMGPGGISREDPNLDIRDVHYSQYGRICPIETPEGMNIGLIMSLASFAKIDENGFLMAPYRKIKAGVITDEVEYLTALREDEHIIAEISSLVNISNDNKILDKEIIGRYRSMQGLYDPLKIDYIDVAPHQVVSIGSSLIPFLENDDSARALMGTNMQRQAYPLIKPYAPAVGTGQEHKIASDSGLTMSSPCSGVVSYVDNSKIIITSDSSKKETVNLVKFERSNQNTCYNHKPIVEIGQRVNKDEIIVDGPAVNKSELALGQNVLVAFTTWNGYNYEDAIVISERLVKEDILTSLTINEYVAQCLSTKNGDEQITRDIPNVSDANKRYLDENGIIMVGAEVKEGDVLVGKVSPKGQVEVSPEEKLFKAIFPESVQNVRDSSLKVSHGGDGIVSAVKRFSIANGDELNDGVIEMIKVYVVQKRKIQIGDKLAGRHGNKGVISKVVPIEDMPHLEDGTPVDILLNPLGVPSRMNIGQIFETHLGYAAHKLAVRSLISSCFDQNKAKEFAIEINQPQARVERLIKGLKNQINDRNIKSEKEALEKLDNSDISLVLKEIGMSFDDLIYKIATPIFQGVNFLDLQDVMQEAGLDPQKNQGKFKLIDGRSGMPFERPISLGIMYMMKLNHMVDDKIHARAVGPYSKITQQPLGGKSQNGGQRFGEMEVWALEAYGAAYNLQELLTIKSDDVQGRNRAYAAIVKGAAFPEPGIPESFKLLTKELQGLALSVSFIYDDNTQQDSNNVSILQSDGEQDEFFNDFEFDTEGY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RL21_SULNB
Sequence: MYAIIKASGQQFKVQEGDIICFDNMGLEPKSAVEFKEVLAVDNGELTVGTPFVEGAVVKGEVINEGRDKKVIIYKKRRRKDSKLKRGFRRDFTRVRITKIA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ARGB_BURM9
Sequence: MSEPIDLSQISPALKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDQALKKIGKQGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVTLINHFGGHAVGLTGKDGGLIHARKLMMPDRDNPGEYVDIGQVGEVEAINPAVVKALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLVMMTNIPGVMDKEGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAP3_YEAST
Sequence: MTPSNMDDNTSGFMKFINPQCQEEDCCIRNSLFQEDSKCIKQQPDLLSEQTAPFPILEDQCPALNLDRSNNDLLLQNNISFPKGSDLQAIQLTPISGDYSTYVMADNNNNDNDSYSNTNYFSKNNGISPSSRSPSVAHNENVPDDSKAKKKAQNRAAQKAFRERKEARMKELQDKLLESERNRQSLLKEIEELRKANTEINAENRLLLRSGNENFSKDIEDDTNYKYSFPTKDEFFTSMVLESKLNHKGKYSLKDNEIMKRNTQYTDEAGRHVLTVPATWEYLYKLSEERDFDVTYVMSKLQGQECCHTHGPAYPRSLIDFLVEEATLNE
What is the function of this protein?
Transcription activator involved in the regulation of genes expressed in response to environmental changes.  When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide.  When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity).  Preferentially binds 5'-TTACTAA-3'.
What are the official names of this protein?
AP-1-like transcription factor YAP3.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. YAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HPR_BACCZ
Sequence: MKSGEKDYSVKEAMIFSQRIAQLSKALWKCVEKDWQMWIKPYDLNINEHHILTIAYHLKGASISEIAKFGVMHVSTAFNFSKKLEERGYLVFSKKEDDKRNTYIEITDKGEELLLRLMEEYDPENNSVFNGALALRNFYGKFPENIELIAILRNIYGQDFIDIFEKSLEDIEENFTESDQKLVKK
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: ACEK_ECOL5
Sequence: MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHLYDHHVGLVVEQLRCITNGQSTDAAFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDLPLRLRWQNKSRDIHYIVRHLTETLGTDNLAESHLQVANELFYRNKAAWLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPLPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDVYAYRRRQRFSVRFV
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFTN2_HUMAN
Sequence: MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFTLQASSNPEVIKINSILDIVTKVENYYLKGYIVGAIHPVIQPVGQRKHLPASYLYRVVLLRLKLSPKNSAAPSGQRRPRLVIEECPLTSEAQTNDAAKELIEKINVAAKRGMKFVGFISQHYSPSKFCNGTNHDGDIESMLHVRHGSDENCRSWNEGTLSGQSSESGIEEELHHESGQYQMEQNGSPTSSKSRKGEASDNKLYTVFNAFDDDSTSWAYQEGILSMKVTRKGSVISTLDADWLELTTFYYKQGLSLIDSFVFWETSKGEHLPKSLEGFFIYEEEGSGVPGSSRKGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPVLRHDSEGNLATKQIVFLQRPVMWNSAAQTPDKKASRHIKGEDKNKATSRSIGLDTTSSQPAESRHLPEECRLSPSRECWTKEGRLAQHNSFSGFSSSDNVLRELDDGQFDQEDGVTQVTCM
What is the function of this protein?
Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production.  May regulate B-cell antigen receptor-mediated signaling.
What are the official names of this protein?
Raftlin-2, Raft-linking protein 2.
What is the protein family that this protein belongs to?
Belongs to the raftlin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GDA0_WHEAT
Sequence: MKTFLILVLLAIVATTATTAVRFPVPQLQPQNPSQQQPQEQVPLVQQQQFLGQQQPFPPQQPYPQPQPFPSQLPYLQLQPFPQPQLPYSQPQPFRPQQPYPQPQPQYSQPQQPISQQQQQQQQQQQQQQQQQQILQQILQQQLIPCMDVVLQQHNIAHGRSQVLQQSTYQLLQELCCQHLWQIPEQSQCQAIHNVVHAIILHQQQKQQQQPSSQVSFQQPLQQYPLGQGSFRPSQQNPQAQGSVQPQQLPQFEEIRNLALQTLPAMCNVYIPPYCTIAPFGIFGTN
What is the function of this protein?
Gliadin is the major seed storage protein in wheat.
What are the official names of this protein?
Alpha/beta-gliadin, Prolamin.
What is the protein family that this protein belongs to?
Belongs to the gliadin/glutenin family.
Protein: Y045_METTH
Sequence: MIRRPAVAGAFYERDPAALRRRIEWCFEHELGPGTLPAVGSMRRIKGVIAPHAGYMYSGPVAAHAYHELVSDGIPGTLVIICPNHTGMGSGVSLMQQGAWETPLGTVEIDSELAEAIVRESGIIDLDETAHLAEHSCEVHVPFIQYFTDNFRIVPVTMWMQGHETAADVGHAVASAIRETGRDAAVIASTDFTHYSPQDIAEATDRRIIDRITAMDDTGMYGVISELNATMCGYGPVAATIIASRILGATECDLLRYATSGDVTGDRSSVVGYAHLS
What are the official names of this protein?
MEMO1 family protein MTH_45.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: SSUD_AGRFC
Sequence: MSKHDKPLDFLWFIPTSGDGSYLGSDDLSRPADPGYFREIAQAADRLGYSGVLIPTGVACEESFILAANLAAYTEKLKFLVAIRPGVASPAYYARLASTLDRVSHGRLLLNIVVGGSAQELAGDGIFLPHDERYDHADEFFQVFNSLIETGKGDLDGKYIKAQGARLGLPPVQEPRPPLYFGGSSDAGIEFSAGITDKYLTWGEPPAQVAEKIVKVRAAAAKNGREVTFGIRLHFIVRETDEEAWADADRLISKLSDETIASAQEVFSKASDSVGQARMQALHNGRRDKLEVSPNLWAGIGLVRSGAGTALVGSPKTVAARLREYQALGIDTVIASGYPHLEEAYRLSELLFPEIGIDGPRNQIRSSFGAKQVFGGGGHGGNVKLVSGS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: SYGB_STRZT
Sequence: MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAIQTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVEDIEFREIKGEEYVYVTKEEVGQSVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVHTLTVLLDEQEFDLDFLDIKGSRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCEREQMIVDQIKEIEAKHGVHIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTSMKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQKLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIYKFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAVLAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYALKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEVSKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQLKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_CLOK5
Sequence: MKCPYCGYGESKVVDSRATDDKMAIRRRRECLKCNKRYTTYEKIENVPLLVIKKNMSREYFDRTKILNGLMKACQKRPVSRKQIEEIADEVEKKISNSVLTEINSSDIGEMIMESLKKVDEVSYVRFASVYRQFKDINTFMEEIKNLISNR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: IF27B_MOUSE
Sequence: MKRKFVGAAIGGALAVAGAPVALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGVLGLSTITNIILVAVGTATGARAEGSMGASREQESGPQDPPQELQEPQEPPSCKKQDLNLGKFVGAAIGGALAVAGAPIALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGILGLSTSTNIILGAVGAATGATAAGAMGACREQEPGLQDLQQEPKEPQEPQELQKQQEPQEPQELQKQQETQETQETQELQKTQEPPSYEK
What is the function of this protein?
Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity.
What are the official names of this protein?
Interferon alpha-inducible protein 27-like protein 2B, Interferon-stimulated gene 12 protein B2, ISG12(b2).
What is the protein family that this protein belongs to?
Belongs to the IFI6/IFI27 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UNG_ECO5E
Sequence: MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQHGETPIDWMPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA1_HALMA
Sequence: MQGQNQQQAYDRGITIFSPDGRLYQVEYAREAVKRGTASIGVRTSDGVVLAVDKRIRSPLMERSSVEKIHKADDHIGIASAGHVADARQLIDFARRQAQVNQLRYGEPVGVETLTKEITDYIQQYTQVGGARPFGVALIIGGIVNGEPRLFETDPSGTPYEWKALAVGADRGDIRDYLEEHYDEGMDLDEGVDLALAALASVNDDELSPEGIGVATVDVETETFGQLTDEEKEAHLAEADLLDTGEDADDEAEDEDATEE
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha 1, 20S proteasome alpha subunit 1, Proteasome core protein PsmA 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAC_ECO55
Sequence: MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNNL
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.