PharMolix/UniProtQA huggingface dataset:
Protein: PFF1_ARTBC
Sequence: MVSSRRGFNPIAFTPWPVTILSSLVYLALIIPIIVVHHLVPPAPKESPAGVDLEEAWHDLQHLTRQYHPYNSHSNDEVHQWLLKRIHAISATSARSESQSGPEVFVFDDNQTNLTFSSAGVAATAITGVYFESRNIVVYIRGTEDEPGEWWKSPDGEPSGKGGVLVNAHYDSVSTGYGATDNGVGVITTLQLLKYFTTPGHYPRKGLVLLFNNGEEDFLNGAYAYSQHPMSKFTHTFLNLEGAGAGGRAVLFRSTDTEVTRFYGKSEHPFGTVLARDAFKLKFIRSETDYHVFDGVFGMRGLDVAFMEPRSRYHTDQDDARHTSIDSVWHMLSAAITTTEGLVSYTGDAFDGDSGDGGKLNNGIGTLGVWFDFFGSSFAVFQLNTLFGHSVALLVVAPLLLIITSVALFAVDKMYMFSMYTYISESGGQVSLYGLRGMFRFPLILGISTALTIALAFLIMKVNPFIIYSSPYAVWSMMLSTCMFFAWFISCVADFARPSALHRAYSFSWMFGIMWVFLVIATVYQKQHGIASSYFIVFYFAGVAVATWISYLELFGLPKTQDYARRQGRLSDRTPSSDSHFLAPSADELPSSSSAAGRDFNPEDVEDEEPTESTSLLRGQQRTTFANYASARGSQESNISNQGNNSLHPKDHRLEQKWSIYLMSSAWILQFLLVAPIVIILLGQLGLFLTSATYQIGADGGSQLVIYIGIAVLSVLILLPLFPFIHRFTYHIPTFLLFILIGTLVYNLTAFPFSHSNRLKLAFVQEMDLATGNNQASLVGVEPYIHDAVHAIPSVQDGKISCTSHGYGGRTKCSWPGLKPKVAEGPYKDWVSYNISKTKDDKITRFEVSGKNTRACKLLFDSPIADFHVQGSVVDKRLPHTGPKGVSEIRLWSRNWENTWTVDVEWTKKNSERTGKVMCLWSDDNDLHVIPELDLARKFAPWWVAITKLRDGLVEGSYSFKL
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: KDSB_BRUA1
Sequence: MLQTMKTLTLIPARLGSTRLPNKPLADICGKPMIVHVADRAAAAKLGRTVIATDSEEIFKVVAAHGHEAIMTRGDHESGSDRIYEALAKLDPSGEIDAVVNVQGDLPTIDPDTIRRALLPLEDGPADIATLGVEITVEEEKTNPNVVKIVGSPLAGNRRLRALYFTRATAPYGEGPLYHHIGLYAYRRSALERFVKLGPSPLEKREKLEQLRALEAGMRIDVEIVKTVPLGVDTQADLDRARTFCSQAGTI
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP1_METAF
Sequence: MTQSSTPAVETDSKTGSSKAISFQDYLDLSKQAFHNQQPLHLLTQRISFQDWARLRAILAPALYVDYTKIGKEKWDAMSADDFMAMVSNDDFLGDPCVKTQHLIGATYWERVSESKVIGHHQLRAAHQVYTSPDLKTVKLRGHSHATNEHYYVKSGGVWKFAGLKPEVRWNEYKFEEVFKGSYTQSEKHS
What is the function of this protein?
Scytalone dehydratase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (PubMed:29958281).  The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (PubMed:29958281).
What are the official names of this protein?
Scytalone dehydratase-like protein Arp1.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
Protein: MCR1_ASPCL
Sequence: MFARQPLRFAQPLKQGFRKYSTEAPAKGKSSLAPIYISVGLAGLGVGLYRYSTASAETPVVDRPKVFTGGEQGWVDLKLSEIENLSHNTKRLRFEFADKEAVSGLQVASALLTKFKPAEGKPVIRPYTPVSDEDQPGYLDLVVKVYPNGPMSEHLHSMNVDQRLEFKGPIPKYPWETNKHKHICLIAGGTGITPMYQLARQIFKNPEDQTKVTLVFGNVSEEDILLKKELQELENTHPRRFKAFYVLDNPPKEWTGGKGYVTKELLKTVLPEPKEEDIKIFVCGPPGMYKAISGPKVSPKDQGELTGLLAELGYNKDQVYKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: FTSB_YERPY
Sequence: MGKLTLLLLVLLGWLQYSLWLGKNGIHDFVRVKEDVAAQEANNSTLKARNDQLFAEIDDLNGGQEAIEERARNELGMIKPGESFYRLVPDQSRRNAGTPSTQNNAQ
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RS3_MYCTO
Sequence: MGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSSGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAAPAGADRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: QUEC_CLOBJ
Sequence: MNKEKAIVVFSGGQDSTTCLFWAKKKYKEVIAVSFDYNQKHKLELDCAKDICKKYNIEHHILDLNLLNQLAPNSLTRQDITVDKSAPKEGVPNSFVDGRNLLFLSFVAVFAKQKGINTIITGVSQSDFSGYPDCRDVFIKSLNVTLNLAMDYEFEIITPLMWINKAETWKMAYDLGVLDIVKEETLTCYNGIKADGCGECPACKLRKKGYWEFEKYLMN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: SYY_STRMU
Sequence: MTIFEELKARGLVFQTTDEEALKKSLDDGQVSFYTGYDPTADSLHLGHLVPILVMRHLQLAGHKPYALVGGATGLIGDPSFKDDERSLQTKETVKNWVQSIRSQLERFIDFKHGDNKAQMVNNYDWMGKITFIDFLRDVGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFYVLNQEHAVTLQVGGSDQWGNMTAGTELIRRKANKTAHVITVPLITDATGKKFGKSEGNAVWLDADKTSPYEMYQFWLNVMDADAIRFLKIFTFLSLDEIEDIRVKFEAAPHERLAQKILAKEVVTFVHGQTAYQEAVKITEQLFAGHIKSLSAKELKQGLSNVPNYAVKSNDNHNIVELLVTAGIVNSKRQAREDLQNGAIYINGERIQDLTYNLSQQDKIDNELTVIRRGKKKYFVLTY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNZ_STAAB
Sequence: MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPIVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQTLIQNEDTPNFNFVKDFDSFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: GPA2_DICDI
Sequence: MGICASSMEGEKTNTDINLSIEKERKKKHNEVKLLLLGAGESGKSTISKQMKIIHQSGYSNEERKEFKPIITRNILDNMRVLLDGMGRLGMTIDPSNSDAAVMIKELTSLQASIVTDCWGELNEDQGKKIKALWTDPGVKQAMRRANEFSTLPDSAPYFFDSIDRMTSPVYIPTDQDILHTRVMTRGVHETNFEIGKIKFRLVDVGGQRSERKKWLSCFDDVTAVVFCVALSEYDLLLYEDNSTNRMLESLRVFSDVCNSWFVNTPIILFLNKSDLFREKIKHVDLSETFPEYKGGRDYERASNYIKERFWQINKTEQKAIYSHITCATDTNNIRVVFEAVKDIIFTQCVMKAGLYS
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses (PubMed:2539262).  Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells (PubMed:27237792).
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-2 subunit, G alpha-2.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: SOPA_SALCH
Sequence: MKISSGAINFSTIPNQVKKLITSIREHTKNGFASKITSVKNTHASLNEKIKTGKSSSIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKINISAEDVSKMNAAFMRKHIANQSRDYNYRVTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSFPSSPADWAKKLTDAVLRQKAGETLTAADRDFSNADFRNITFSKILPPSFMERDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNEVFLQYSITTQQQPSFIDTTLKNTLIRHKANLSGVILHEPDNSSPPSVSRGGNFIRLGDIWLQMPLLWTENAVDGFLNHEHNNGKSILMTIDSLPDKYSQEKVRAMEDLVKSLRGGRLTEAGIRPVESSLVSVLAHPPYTQSALISEWIRPVQERFFAHQCQTYNDVPLPAPDTYYQQRILPVLLDSFDRNSAAMTTHSGLFNQVILHCMTGVDCTDGTRQKAAALYEQYLAHPAVSPHIHNGLFGNYDGSPDWTTRAADNFLLLSSQDSDTAMMLSTNTLLTMLNPTPDTAWDNFYLLRAGENVSTAQISPVELFRHDFPVFLAAFNQQATQRRFGELIDIILSTEEHGELNQQFIAATNQKHSTVKLIDDASVSRLNTIFDPLLPEGKLSPAHYQHILSAYHLTDATPQKQAETLFCLSTAFARYSSSAIFGTEHDSPPALRGYAEALMQKAWELSPAIFPSSEQFTDWSDRFHGLHGAFTCTSVVADSMQRHARKYFPSVLSSILPLAWA
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase SopA, HECT-type E3 ubiquitin transferase SopA, Salmonella outer protein A, Secreted effector protein SopA.
What is the protein family that this protein belongs to?
Belongs to the SopA E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cell.
Protein: EBP2_MOUSE
Sequence: MDTPPLSESDSESDACLASDQELQDAFSRGLLKPGLNVVLEKPKKAVNDVSGLKQCLAEFRRDLEWVERLDVTLGPVPEVSETQPTPQNQDQKKGVNPEDDFQREMSFYRQAQAAVLAVLPRLHQLQVPTKRPTDYFAEMAKSDQQMQKIRQKLQTKQAAMEKSEKAKQLRALRKYGKKVQTEVLQKRQREKAHMMNAIKKYQKGFSDKLDFLEGDQKPVERSAKAGGKGQQMSKGPNAKRRYKNQKFGFGGKKKGSKWNTKESYDDVSSFRAKVAHGKGSRRPGKKGANKRPGKRARQKLKSKAR
What is the function of this protein?
Required for the processing of the 27S pre-rRNA.
What are the official names of this protein?
Probable rRNA-processing protein EBP2.
What is the protein family that this protein belongs to?
Belongs to the EBP2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FLIW_CAMC5
Sequence: MTFSVKSPILGFEHIKTMELIELDKFFVKLQSKDDETSFTMINPFALRSYEFDIPSYYEELMDIRDTSQLRIYNIIVVSLPLEKSTVNFVAPIVCNMDNMTLSQVVLDVGAYPQYGQAEPIENFIQK
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCK_SAISC
Sequence: MGCGCSSHLEDDWMENIDVCENCHYPIVPLDGKATLLFRNGSEVRDPLVRYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEHLRILEQNGEWWKAQSLTTGQEGFVPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFSGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHKRLVRLYAVVTEEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILMTEIVTHGRIPYPGMTNPEVIQNLERGYRMPRPDNCPEELYKLMMQCWRERPDDRPTFDYLRSVLEDFFTATEGQYQPQP
What is the function of this protein?
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells.  Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways.  Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors.  Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex.  LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway.  Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK.  Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production.  LCK also contributes to signaling by other receptor molecules.  Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK.  Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response.  Binding of IL2 to its receptor results in increased activity of LCK.  Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR.  Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity).
What are the official names of this protein?
Proto-oncogene tyrosine-protein kinase LCK, Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Note=Present in lipid rafts in an inactive form.
Protein: EFTS_PSEPW
Sequence: MAAITAALVKELRERTGEGMMDCKKALEKAGGDIEKAIDDMRASGAIKAAKKAGNVAAEGAIAVKTDGKSAVLLEVNSQTDFLALQDDFKNFVAESLEEAFAQKLTDAAPLIASREAAREALVAKCGENVNIRRLVRVEGDVVGAYLHGNKIGAVVVLKGGDVELAKNIAMHVAASNPEFLDASEISAEAIEREKNVFLQLNADKIAGKPGNIVENMINGRITKFKAEASLKEQAFVMNPEVKVGELAKKAGAEIVSFTYFKVGEGIEKPVDDFAAEVAAQVAAAKQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_CHLP8
Sequence: MKRDFRALLNPALERIEAYKVEGGQDAEVKLNQNESPFDLPMWLKDKILDEFRREPWNRYPDILPYRGMATYASFLGVPAESVIMSNGSNEMLYTIFMACVGAGRKVLIPEPSFSLYDKLAVLLQGEIVSVPLNPDLSFDVDAIIAAAEREKVDFIVLSTPNNPAGKSMSHDEVERIVSTCDAIVLADEAYIEFSQQESVVDLIDRYPNLIVLRTMSKALALAGMRIGFAITNPELMAEITKPKIPFASGRLAEITLANVLENYSLVTDAVHYILAERQRMEQELAGIAGVEVFESDTNFLIIRVGNAKEVFTKLREGGVLVRNVSGYPLMQNCLRCNIGLIEENDRLLELLKSC
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: SYR_SALPA
Sequence: MNIQALLSEKVSQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLSGIASKVEIAGPGFINIFLEPAFLAEQVQQALTSDRLGVSQPTRQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHHVIRANHVGDWGTQFGMLIAWLEKQQQENAGDMALADLEGFYRDAKKHYDEDEAFAERARNYVVKLQSGDTYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGDPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSVPLEHHMFGMMLGKDGKPFKTRTGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKADIDEQALASAPVIISEDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDVAGLFSGFYEHCPILSAENDAVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_LYSSC
Sequence: MTLRIVSGRSGTGKSVFIHQEIVEQLKSDPLGHPIFIIVPDQMSYSTEYELTNRHGLQGLIRAQVMTFKRLAWLVLQETGGIARKEVNGYGYRMLIRKLLEEQKSEFSLFRQAAGKRGFTEEIETLLKEFSRYSVNSSVLAEVKESLKAIDAPNTLQAKTNDLYVVLQALEERLGTTYVDSEGYYPILTEQLKYAETMKQATIYIDGFTAFTVRELELVRELLKVTKHVTVVLPFDHIDEAFDEQALFHEAALTNQRLHDIANEEGIDVEPPLHFYYTQRFQSEDLQHVEANFANMVPHTKKTSGDVMVFEASNRRAEVHAIAREITKLTREYGYRYQDIVLLYRQAELYDPLITSIFQQYEIPIFTNTKKTMLHHPLIELSRSALEIMTSNWKYEPVFRSVKTDLFFPLQAELTIWRERADRLENYCLAQGIYGERWFEEPRWFYKKYRGLEFHSRVQTDEERAMQAEIEAIRDEIRQPLKSLQDKLSIASTGKDIATALFELVESLQVYEKLQAMKDRELERGDALAASEHEQAWNEWINVLDQFVYMFGEQEMSVEEAAKILDEGFDTLEFSRIPPTLDEVMVATVDLARLSNIKVAFVLGMNDGVYPTRMEYEGLLSDTEREWFSQIGYELAPTSSNRLLQENFLFYRAASTPSNKLYLTYPTADEEGKALLSSLYIKKFIGNDKIAGLLSGVQAERVVMDPIELLDESALPYLRHPRTALAHLMVQLRQAEHSRELAPEWLALQKFYQQDPYWALIFDRVHYPITHKNEAEPLETYITQELYGQKLTSSVSRIEKYFRCPFSHFTTYGLRLEERAEYRLETFAMGDLFHEALKWITEETHRLQLSWIRLTKQQIKQLARQAVEQIVPVFSHQILLSSARYRYIQRKLIRIVERTMMALTQHANVSHFKPIAIEASFGPGQHEQLPPLEIDLTSGKKMFMRGRIDRIDSATIDDRSYLRIVDYKSSARDLDLNEVYYGLSLQVLTYLDVAMENSTYWLPGETEPAGVLYVHVHNPMLKLDKDMTDSEIEEDRLKQYKMKGLLSENAESILSMDEQLEESSGHSKIIPVYMKKDGTPSESQSRIVPVNDMKRLQHFVRRKHQEAGNGILSGDTAISPYKLKSKTACDYCQFAAVCQFDPSDGKQNYRQLMQAKPNEIVDKIRKEIE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: CXA1_RABIT
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.  May play a role in cell growth inhibition through the regulation of NOV expression and localization.  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65.
Protein: MRGRE_HUMAN
Sequence: MMEPREAGQHVGAANGAQEDVAFNLIILSLTEGLGLGGLLGNGAVLWLLSSNVYRNPFAIYLLDVACADLIFLGCHMVAIVPDLLQGRLDFPGFVQTSLATLRFFCYIVGLSLLAAVSVEQCLAALFPAWYSCRRPRHLTTCVCALTWALCLLLHLLLSGACTQFFGEPSRHLCRTLWLVAAVLLALLCCTMCGASLMLLLRVERGPQRPPPRGFPGLILLTVLLFLFCGLPFGIYWLSRNLLWYIPHYFYHFSFLMAAVHCAAKPVVYFCLGSAQGRRLPLRLVLQRALGDEAELGAVRETSRRGLVDIAA
What is the function of this protein?
Orphan receptor.  May regulate nociceptor function and/or development, including the sensation or modulation of pain.
What are the official names of this protein?
Mas-related G-protein coupled receptor member E, G-protein coupled receptor 167.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_SHEB8
Sequence: MNIRPLHDRVIVKRLEVESTSAGGIVLTGSAAEKSTRGEILAVGNGRILENGTVKPLDVKVGDVVIFNEGYGVKKEKIDGQEVLILSEADLMAVVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_CAMJE
Sequence: MKLSEIAEFLSLEYKGEDIEISALNSLLKANFTELTYCDGEKNTKDIPHTGAAAILVSKEYENLVPKDTKALITQSPHLSFAFLSKLFAKPLISTAKEKVQNIAKSARIMPNVYIGDNVNIGENVIIMAGAYIGDNVSIGDESIIHPNVVIYNDTKIGKKCHLLANCVIGSDGFGYAHNKNGEHYKIYHNGNVVLEDFVEVGACTTIDRAVFDSTIIKAGTKVDNLVQIGHNCNIGQNCIIVAQTGISGSSELGRNVIMGGQSATSGHLKIGDFSTIAARGGVSKNLEGGRVYGGFPIMLQKDWLKLQAKIAINFKEKSQD
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: PCKG_ACIBT
Sequence: MTTVNAPEFVRHPKLIAWVEEIANLTKPAKIEWCDGSEEEYQRLIDLMIANGTMQKLNQEKHPGSYLANSDPSDVARVEDRTYICSQNKEDAGATNNWEDPAVMREKLNGLFEGSMKGRTMYVVPFSMGPLGSHIAHIGIELTDSPYVAVSMRKMARMGKAVYDVLGTDGEFVPCVHTVGTPLAEGQKDVAWPCNPEKYIVHYPETREIWSFGSGYGGNALLGKKCLALRIASVMGREQGWLAEHMLILGVTNPQGEKHYIAAAFPSACGKTNFAMLIPPAGYEGWKIETVGDDIAWIKPGEDGRLYAINPEAGFFGVAPGTNTKTNPNCMATLHKDVIYTNVAVTDDGQVWWEGLSKEVPANLTNWKGQPHVNGEKAAHPNARFTVAAGQCPSIDADWENPAGVPISAFIFGGRRADTVPLVSEAFDWVDGVYKAATMGSETTAAAVGQQGIVRRDPFAMLPFAGYNMADYFDHWLNLGAKVSEKAEASGNKLPKIFNVNWFRRDAEGNFVWPGFGQNMRVLEWIIDRCEGRANAVETPIGFVPTYEDLNWEGTEFTKEQFDLITNQDKDQWVTEIESHTELFNKLGERLPKALKERQAALLEAVKLASN
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.