PharMolix/UniProtQA huggingface dataset:
Protein: DEXT_STRDO
Sequence: MNNRMLSFPSMLFLLAFGIVLSVSAGTTHADELANQTAKVADEASIVVSTSQAAVEQTQSQEKEISPAMEEDTSNLSLKPNAQQESQSPDSSTELQDPAEQTPPETSDASAPATTSADSVEKYAQDATQNQSSTSNGPGVIRATSAQVTATRSVVSSQSGDAIVDLSADKASYRQGEDVNLSVDFKNTTDKEQDVTVYADVYYIDNKLGTYKFSKHLKAGEGYKMQSGDLKIPASQFENNHGYLLKVRVRDADNNTLSEVNKAIAVESDWTKFPRYGIVGGSQDTNNSLLSKDADRYRAEIEKMKNMNINSYFFYDVYKTATNPFPSDEATFKQDWNTWSGSEIDTQAVKDIVNQVHDGGAVAMLYNMILAENTNTGEAPVLPETEYAYNSDDRGYGAQGQPMSYTVKIPKDGQEEDVEIQRYYNPTSKLWQDYIADKMGQAMKNGGFDGWQGDTIGDNEVYSYADKDSNDPSKKFWLTEGYAEFLRAIKEKLPNYYLTVNDVNGEQIYRLKDGNQDVIYNEIWPFGPALPSEMAAVKPNTVTSRPVLTKVRQGDWKISIVGAYMEGSENGGSKADAEAGKSLQTDAVLLTSASIAAAGGYHMSLAALANQQDETDGGQGIGVLQTAYYPTQSLKTSSELTRKNNDYQQFITAYENVLRDGVENDDAQVNTFDSNGQKLSTDAKGITGNQVWTYGKKGDNFRTVQLLNLMGINSDWKNEDGSAANKTPDEQTNLTVKYALGDVSMEDAQRMANQTYVTSPDDWSKSNLQKVSASVKTDENGKPVLVINVPKLTLWDVVYISNANQESAPEADQAQTPAAQSSDDKVAENETSQPAAEDAKEQTSEPAQDQAAPAEQGQAINQAESPATEPEAEVTPATAEPAKVDAPEANQAADQAVSPEPASQEQAASQSQPEANQTPASNETPATQGNSEQPELNEPTAQTQPSSQVSPANTSVTPVAEQPTNQGQAADKADQAPTNSTSTPESTSPVEPAATDQSSDTPIVTAGNLSVQPAETETPTVPDKQGDSKANQSSTETPVADQVPAVAEQPQATEPNQAKPSVDKAAAPEALSLIQLKQQTPAIQAKEADDPEVDETKSEVTPDSGTDKAPEAGQVDSDKAPTVKPSTPENNDNQPNNANDADKNKTNEADSNKANQDSTKGSSADQSGKSTTPEDGPDNSSPEDPETKPSDPNTDTSDQEQVKPSLPVVPNQTVDDPKTDDTDTPANTDSAKSKKVADADKNKVATDSEGRQKSSEFPKEATDLEKVGQPASPQVAGVKSSVATSPEKKSEPVSKTSTTSSSDKLPKTGDHKTVVLIIVLGLVFVGMTGLLARHEKK
What is the function of this protein?
May play a role in sucrose-independent adherence to the pellicle-coated tooth surface.
What are the official names of this protein?
Dextranase, Alpha-1,6-glucan-6-glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 66 family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: NADD_THEP1
Sequence: MNTGNRIGIFGGSFDPIHTGHVLVSVYTLEILDLDRLIVVPVFNPPHKKTVAPFEKRFEWLKKVFEGMEKVEVSDYEKGRGGVSYSIFTIEYFSEIYKTKPFFIVGEDALSYFEKWYRYRDILEKSTLVVYPRYCGKPYHEHARRVLGDLSEIVFLDMPIVQISSTEIRERARIGKTLKGFVPEEIREEVEVFYGA
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: PNCC_ECOL6
Sequence: MTDSELMQLSEQVGQALKARGATVTTAESCTGGWVAKVITDIAGSSAWFERGFVTYSNEAKAQMIGVREETLAQHGAVSEPVVVEMAIGALKAARADYAVSISGIAGPDGGSEEKPVGTVWFAFATARGEGITRRECFSGDRDAVRRQATAYALQTLWQQFLQNT
What is the function of this protein?
Has NMN aminohydrolase activity, not active on other substrates.
What are the official names of this protein?
Nicotinamide-nucleotide amidohydrolase PncC, NMN amidohydrolase PncC, NMN deamidase, Nicotinamide-nucleotide amidase.
What is the protein family that this protein belongs to?
Belongs to the CinA family. PncC subfamily.
Protein: UREF_STAAW
Sequence: MIDHTHLRLFQFCDSQFPTGAFSHSFGLETYIQRNIIHDDHTFIAWLKMFLQEQLTYSDGLAMRLVYDALENDDTQKVLHIDKLMFVQNLPKETRVGAKQMGTRMVKLALELYNSPWIAWYHQQMQDKKAKLNPAICFTMLGHHLGVDIETIIDYYLYQNVSSLTQNAVRAIPLGQTAGQKIVTHMIPYIEGTRKQIFELKEADFGMTAPGLELNQMAHENVNVRIFIS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_STAAT
Sequence: MENQKQYPMTQEGFEKLERELEELKTVKRPEVVEKIKVARSFGDLSENSEYDAAKDEQGFIEQDIQRIEHMLRNALIIEDTGDNNVVKIGKTVTFVELPGDEEESYQIVGSAESDAFNGKISNESPMAKALIGKGLDDEVRVPLPNGGEMNVKIVNIQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: COXX_BACHK
Sequence: MNHATSELHDESAVTSIPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVMDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LOLA_ECOLI
Sequence: MKKIAITCALLSSLVASSVWADAASDLKSRLDKVSSFHASFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPQGVTVDDQRK
What is the function of this protein?
May act as a regulator of the RCS-phosphorelay signal transduction pathway.
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein, P20.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y598_XYLFA
Sequence: MLLHIPTILSRTQATSMQERLAAANWTDGRETVGPQGAQVKHNLQLPETSPLRQELGNEILDALARSPLYFAATLPLRTLPPRFNCYQENHQYGFHVDGAVMSLPIAPGHTPASLRSDISCTLFLNDPDEYEGGELIIADTYGEHEVKLPAGDLIIYPSTSLHRVAPVTRGMRIASFFWVQSLVRQATHRHQLLELDTAIQSLTASNTDHNTILRLTNIYHNLLREWSET
What are the official names of this protein?
PKHD-type hydroxylase XF_0598.
Protein: LIPA_RICCN
Sequence: MANLNKRPDWIKVKAPNSTEYYNTKDLIKNLRLNTVCEEAACPNIGECWSKKHTTVMILGSVCTRACRFCNVKTGRPDLLDPYEPQRLAEAVQKLNLKHVVITSVDRDDLEDGGASHFAECISEIRKSSPNTTIEILTPDFLRKEGAAEIIANAKPDVFNHNVETVPSLYKTIRPGARYYNSLSLLHNIKKLSPEIFTKSGMMVGLGEEINEVVQVIDDLREAKVDFLTIGQYLQPTKNHAEVAKYVTPEEFKYLERVAKTKGFLMVSASPLTRSSYHADEDFQKLKENYQQKLVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL19_HCMVM
Sequence: MTSNALYELFRRRLPRAPVNTVMFLTRRTRDGFCGRLTSIATNSHYTMFVLDHGSVRIERPSQSEVDCASLMETLKRIRLRNSWVASEDELDVSRRDA
What are the official names of this protein?
Uncharacterized protein UL19.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL19 protein family.
Protein: TAL_SORC5
Sequence: MKVFIDSGDIAEIKEAQSMGVVDGVTTNPSLLAKAGKPTKRAIAEICEVVDGPVSAEVVAVEKDAILREGRELAKIHRNVVVKVPLIDEGLKAARIFASEGIKTNVTLCFSAAQALLAAKAGATYVSPFVGRVDDAAGDGMDLVLQVVTIFRNYGFSTQVLTASIRHPVHFVQAAMIGSHAATMPLKVIKQLTRHPLTDVGLAQFLADAKKIPELV
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_PSEAE
Sequence: MLLLLAEYLQQFYKGFGVFQYLTLRGILSVLTALSLSLWLGPWMIRTLQIRQIGQAVRNDGPQSHLSKKGTPTMGGALILTAIAISTLLWADLSNRYVWVVLVVTLLFGAIGWVDDYRKVIEKNSRGLPSRWKYFWQSVFGIGAAVFLYMTAETPIETTLIVPMLKSVEIQLGIFFVVLTYFVIVGSSNAVNLTDGLDGLAIMPTVMVAGALGIFCYLSGNVKFAEYLLIPNVPGAGELIVFCAALVGAGLGFLWFNTYPAQVFMGDVGALALGAALGTIAVIVRQEIVLFIMGGVFVMETLSVMIQVASFKLTGRRVFRMAPIHHHFELKGWPEPRVIVRFWIITVILVLIGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SARM1_DROME
Sequence: MKAAEIKRDLTNIQKSMSEINDLAKERITGGPGSISTTSASAITAPSTMSQTTTSRLAPKLTSAHPSIDDLRGLSRQDKITQLQKKIRASFENLVDHDDSNVIVTLPDDDDCPHNHFGSGLNLTHPTAAQLSASGLSGSSKTIDTIKFQEKSMKTESKTKVVTDGFSSEQATSNSAEMKRLQAGDIDYQESKGASAMRNRLEVDGVKTEENAAVIKEALSLRTGDITQQASNNVAASSITVQSENFSADKKAISQSQQSQTMTSNGIISQEKHVSSASQANYSMSHKGVSSTGSSMITSSSQMSAMNGQMLKLADLKLDDLKSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQFSSAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVANKEIEAEVLKSGCLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKNLENSLPSSSEENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQDACIDKLERFLRGEKNIDRIAAMVPGTPGSVSYQRMHSNDSDYQSGGAGAGSGAGTGGGGGGGVTGSVVDGLMVAANGSGQANHQANRYRQSPSPARQRGSTSQLSGYSRAPSKRSQILTPYRTQQAALLHKTGAGSASMQNMMPLAYLPPRRSSAAGLGHGSGSGMGSGYRSHSVDGLLDQAGSTPEQRIAAAAAKVTAGSTALTNASSTSTLQPEEEVTDAALNDSVTRRDKHTLSPPGNVQQHRKSRSLDHILSKQTLAELLPPSSELADGTQSMQNLAIPMTPQPQRRDTSSSSKSPTPERPPQPAMERVRERQSPEGVSATESEREDQPEECLRHGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGGNNKTIFNRTMKKVRSLIKKP
What is the function of this protein?
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:22678360, PubMed:28334607).  Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:22678360).  Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting axon destruction (PubMed:22678360, PubMed:28334607, PubMed:31439792).  Involved in the down-regulation of the tracheal immune response to Gram-negative bacteria (PubMed:22022271).  This is likely by mediating Tollo signaling in the tracheal epithelium (PubMed:22022271).
What are the official names of this protein?
NAD(+) hydrolase sarm1, NADase sarm1, Sterile alpha and TIR motif-containing protein 1, Tir-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SARM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, axon.
Protein: Y2368_GEOKA
Sequence: MFQFQFPLYNDIVEQARREAVEAGFEELRTPEDVDAAFRRPGTTLVLINSVCGCAGGIARPAAAHAVHYDKRPDHLVTVFAGQDKEATARAREYFVGEPPSSPSFALLKDGKLCAMLHRHDIEGHEPVAVVQKLQALFDEYCEEV
What are the official names of this protein?
UPF0403 protein GK2368.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: CLF1_CRYNH
Sequence: MAGRDPRDRAPRVRNRAPAAVQITAEQLLREAQERQEPTIQAPKQRVQDLEELSEFQARKRTEFESRIRYSRDSILAWTKYAQWEASQNEYERSRSVFERALDVDPRSVDLWIKYTDMELKARNINHARNLFDRAITLLPRVDALWYKYVYLEELLLNVSGARQIFERWMQWEPNDKAWQSYIKLEERYNELDRASAIYERWIACRPIPKNWVAWAKFEEDRGQPDKAREVFQTALEFFGDEEEQVEKAQSVFAAFARMETRLKEFERARVIYKFALARLPRSKSASLYAQYTKFEKQHGDRAGVELTVLGKRRIQYEEELAYDPTNYDAWFSLARLEEDAYRADREDGEDVEPMRVREVYERAVANVPPALEKRYWRRYIYLWLQYAAFEEIDTKDYDRARDVYKAAVKLVPHKTFTFAKLWLAYAYFEIRRLDVSAARKVLGAGIGMCPKPKLFTGYIELEMRLREFDRVRTLYEKFLTYDPSLSSAWIQWTQVESAVEDFERVRAIFELAVQQSLDMPEIVWKAYIDFEAGEGERERARNLYERLLERTSHVKVWISYALMEIATLGGGEDEDGNEIEGEAGDADLARKVFERGYKDLRAKGEKEDRAVLLESWKSFEQEHGDEEMLAKVEDMLPTTRKRWRKAEDGSGELEEYWDLVFPDDEKEANPTSFKFFQAAQAWAQQRAGQGEEGGLSYDLPSDSESENEDEDGDNREEEGMDQD
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle progression.  Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CLF1, crooked-neck-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the crooked-neck family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GDO2_PSEAC
Sequence: MSELNLGTVEDLPKDYYEQLVANNTLPLWPSLRSVLPHGKPARRTRPVIWRYADVRPDLLRAGDLTPIEKAEGRVLVLCNPGLGLENMQVTGSIYIGLQLIQPGETAPNHKHSPSAVRFVIEGKGGYTLVNGEKLPMEKGDLILTPPGMWHQHGHEGDGPVVWLDALDLPLIYGIDASYHIDGEEQTLDKAAGTCTSRYRQSGLLPYSALDRKTSFPLLRFPWQEVRESLKQFAAVTPAGELVQLAYVNPETGAECLPTLGFSAIMLRPGETIRLQRRSASGVLHVVEGAGSVVVDDTRHAFTEADTLAIPTHAAVTLSNASSTEPTYLFMVDDAPLHRKLGIYEVFS
What is the function of this protein?
Involved in the degradation of gentisate.  Catalyzes the conversion of gentisate (2,5-dihydroxybenzoate) to maleylpyruvate.  Can also use other substrates such as 3-bromogentisate, 3-fluorogentisate, 3-isopropylgentisate, 3-methylgentisate and 3-ethylgentisate, but is unable to utilize gentisate that is substituted at the carbon-4 position.
What are the official names of this protein?
Gentisate 1,2 dioxygenase 2, GDOII.
What is the protein family that this protein belongs to?
Belongs to the gentisate 1,2-dioxygenase family.
Protein: SERA_BOVIN
Sequence: MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTSDIINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQAAASMKDGKWERKKFMGTELNGKVLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEQIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVCVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVNHENVISCPHLGASTKEAQSRCGEEIALQFVDMVKGKALAGVVNAQALASIFCPHTKPWVSLAKALGALMQAWAGSPKGAIQVVTQGSSLKNSGSCLAPAVIIGLLKDASQQSNVNLVNAMLLVKEAGLDVTTSHNPATPREQDFGECLLTVALAGAPYQAVGLVQGTKPVLQALNGAVFRPEVPLHPGQPLLMFRAQASNPAMLPTMIGLLAEAGVQLLSYQSSVVSDGETWHVMSISSLLPSLAPWKPHVTEAFQFCF
What is the function of this protein?
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway.  Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
What are the official names of this protein?
D-3-phosphoglycerate dehydrogenase, 3-PGDH, 2-oxoglutarate reductase, Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: DNAA_LISMH
Sequence: MQSIEDIWQETLQIVKKNMSKPSYDTWMKSTTAHSLEGNTFIISAPNNFVRDWLEKSYTQFIANILQEITGRLFDVRFIDGEQEENFEYTVIKPNPALDEDGIEIGKHMLNPRYVFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAVGHYVQQHKDNAKVMYLSSEKFTNEFISSIRDNKTEEFRTKYRNVDVLLIDDIQFLAGKEGTQEEFFHTFNTLYDEQKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKADGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLVNKDITAGLAAEALKDIIPSSKSQVITISGIQEAVGEYFHVRLEDFKAKKRTKSIAFPRQIAMYLSRELTDASLPKIGDEFGGRDHTTVIHAHEKISQLLKTDQVLKNDLAEIEKNLRKAQNMF
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPB_BACC7
Sequence: MMRPVVVKEKRVNESQIHVVEEEVRQAKTMDRDIVTHAMKQSFAKLNPKVMIKNPIMFVVEIGFIITFILSFLPSHSSSVPGWFNITVSFILLFTVLFANFAEALAEGRGKAQADSLKHSKKDVFANVVKENGNIVQVSATDLRKGDVVIVKQGEMIPSDGEVIKGLASVDESAITGESAPVIKEAGGDFCSVTGGTMVVSDEITIIITSNPGESFIDKMISLVEGAARQKTPNEIALNTVLTSLTFIFLIVVVTLPIFTNYLGFQIDTAVLVALLVCLIPTTIGGLLSAIGIAGMDRVTKFNVLAMSGKAVEAAGDINTIILDKTGTITFGNRMAHTLLPVGNETIEQVGKWAAISSVLDETPEGRSVIEYVQAKSISYNRELAEQGEFVPFKAETRMSGVDLQDGTKVRKGAVGSVIEWVQSQGGTIPKDVNQKADFISKEGGTPLVVAVNNRIYGLIYLKDTVKPGMRERFEQLRQMGIKTVMCTGDNPLTAATIAKEAGVDEFVAECKPEDKIAVIKAEQDKGKLVAMTGDGTNDAPALAQADVGLAMNSGTTAAKEAANMIDLDSNPTKIIEVVGIGKQLLMTRGALTTFSIANDIAKYFAIIPAMFTLAIPQMEALNIMKLTSPLSAILSALLFNAVIIPLLIPLAMKGIAYKPMSSNALLGRNLLIYGLGGVIVPFIGIKVIDMIVGLFI
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSB_LACPL
Sequence: MINRTILVGRLTRDPELRYTNGGAAVATFTIAVNRQFTNQNGEREADFISCVIWRKAAENFANFTHKGSLVGIDGRIQTRNYENQQGVRVYVTEVVVENFSLLESRAESERHQAANGGSGNNNYNNGNSNYNNNNNGYSNQGQNAAPQQSSANNNNPFGNGNTGNASSAAPSSSANNNNQADPFANNGDQIDISDDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: TRMA_ECOL6
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPILRHKLFQIDYLTTLRNQAVVSLLYHKKLDDEWRQQAEALRDALRAQNLNVHLIGRATKTKIALDQDYIDERLPIAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: TRHO_ECOHS
Sequence: MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKATRDALYQLFTALNVFGRVYLAHEGINAQISVPASNVETFRAQLYAFDSALDGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPEEQRRRRAGRENGNKIFNKSRGRLNTTLGIPDPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.  May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: DFP1_ANTMY
Sequence: MMFAYIVAVVSALALTSAFPTGAPRSACFDMIPGHFANPKLEPAPYTITTPISAVKGGNSVEVTISGKTPEDTMRGILLEARQGDNIVGTWTVPPGDDFSQPMNCGEPNNAVTHKRHSESADKQTVSYVWTAPSDLEGDVVFMVTIVKDYSNFWVRQTSAPVKILSHH
What is the function of this protein?
As this protein is expressed upon bacterial infection, it may have antimicrobial activity.
What are the official names of this protein?
Putative defense protein 1, DFP-1.
What is the protein family that this protein belongs to?
Belongs to the insect defense protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: FSHB_BUBBU
Sequence: MKSVQFCFLFCCWRAICCRSCELTNITITVEKEECGFCISINTTWCAGYCYTRDLVYRDPARPNIQKTCTYKELVYETVKVPGCAHHADSLYTYPVATECQCGKCDGDSTDCTVRGLGPSYCSFSESRE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways.  Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: CHTOP_MOUSE
Sequence: MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQKSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
What is the function of this protein?
Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity).  May play a role in the silencing of fetal globin genes (PubMed:20688955).  Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859).  Required for the tumorigenicity of glioblastoma cells.  Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH.  The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).
What are the official names of this protein?
Chromatin target of PRMT1 protein, Friend of PRMT1 protein, Small arginine- and glycine-rich protein, SRAG.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Note=Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity).