PharMolix/UniProtQA huggingface dataset:
Protein: DUS28_MOUSE
Sequence: MGTSEAAPPPFARVAPALFIGNARAAGATELLVRAGITLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLTHLEPTCAAMEAAVRDGGSCLVYCKNGRSRSAAVCTAYLMRHRGHSLDRAFQMVKSARPVAEPNLGFWAQLQKYEQTLQAQAILPREPIDPE
What is the function of this protein?
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).  Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine.  The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site.
What are the official names of this protein?
Dual specificity phosphatase 28.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: PSMD9_CAEEL
Sequence: MDHHSKAKELLQQRDELDGKIKELMLVLETNNSTMDSPLLDAEGYPLNTIDVYAVRHARHDLICLRNDRAALTEKIVVEMENENKEVSGQTATSEEKPVHRTSNEPFVKISSVVELSPADIGGFRKDDLIIQYGNLHHGNFNDMQEVAQITKQSEDKIIRVTVIRENRPVRLEICPKKWSGPGLLGCNIVPISGANV
What is the function of this protein?
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
What are the official names of this protein?
Probable 26S proteasome non-ATPase regulatory subunit 9.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit p27 family.
Protein: NBL1_MOUSE
Sequence: MLWVLVGAVLPVMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKIVHCSCQACGKEPSHEGLNVYVQGEDSPGSQPGPHSHAHPHPGGQTPEPEEPPGAPQVEEEGAED
What is the function of this protein?
Possible candidate as a tumor suppressor gene of neuroblastoma.  May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
What are the official names of this protein?
Neuroblastoma suppressor of tumorigenicity 1, N03, Zinc finger protein DAN.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
Protein: PHK_RHOPB
Sequence: MPDPLTSDLLEKMHAYWRAANYLSVGQIYLQDNPLLEVPLRLDHIKPRLLGHWGTTPGLNLLYVHLNRLIKQHDLNMIYIIGPGHGGPGLVAQSYLEGSYTERYPAIERSRNGMQRLFRQFSWPHGIPSHVSPETPGSIHEGGELGYSLAHAYGAAFDNPDLIVACIVGDGEAETGALASSWHSNKFLNPARDGAVLPILHLNGFKIANPTVLARIGRVELTELLRGYGYEPDFVEGDDPAIVHQLLAGTLDRILAQIRHIQDEARNHGVTARPRWPMIVLRTPKGWTGPKFVDNLPVEGTWRAHQVPIADFKAPEHLKLLEDWMRSYRPQDLFDDNGKLRDELVALAPTGHRRMSANPHANGGELLQPLSLPDFHDYAVTLPAPGAVRAESTRVLGKYLRDVMKANLESQNFRLFGPDETASNRLEAVFEVSGKEWMAEVEHVDINLSVDGRVMEVLSEHLCQGWLEGYLLTGRHGLFSCYEAFIHIIDSMFNQHAKWLKVCATIPWRKPIGSLNYLLTSHVWRQDHNGFSHQDPGFIDHVANKKADIARIYLPPDANCLLSVTDHCLRSRNYVNVIVAGKQPEWQWLDIDAAVRHCTAGAGIWRFASNDAGDPDVVMACAGDVPTVEALAAVKLLREYVPDIRVRVVNVVDLMVLQPRSEHPHGLDDRGFDELFTTDKPVIFAFHGYPSMIHKLTYRRHNHHNIHVRGYKEEGTTTTPFDMVVLNDLDRYRLTLDAILRIPRLSGQREAATARYWDSIQRHKLYIGEHGDDLPEIVDWRWTA
What are the official names of this protein?
Probable phosphoketolase.
What is the protein family that this protein belongs to?
Belongs to the XFP family.
Protein: MOBA_BACCZ
Sequence: MSKYAGIVLAGGMSSRFGEPKALASWQGSTFIEHILKVMTSTLQEVVVISHSDIKEPVEKLVQVPVIEDIPHYKGNGPLAGIVSGMEYIEADWYAIMPCDAPNVSHEWFTILLGQTSNEYDAVVPIINGRKQPLLAAYHNRVKEKIYALLQEEKRSMVQLLSQCNVKYIAGEDVQANADWFINVNTKEEYVQAQKDLSNE
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_VILVK
Sequence: MASKESKPSRTTRRGMEPPLRETWNQVLQELVKRQQQEEEEQQGLVSGKKKSWVSIDLLGTEGKDIKKVNIWEPCEKWFAQVVWGVLWVLQIVLWGCLMWEVRKGNQCQAEEVIALVSDPGGFQRVQHVETVPVTCVTKNFTQWGCQPEGAYPDPELEYRNISREILEEVYKQDWPWNTYHWPLWQMENMRQWMKENEKEYKERTNKTKEDIDDLVAGRIRGRFCVPYPYALLRCEEWCWYPESINQETGHAEKIKINCTKAKAVSCTEKMSLAAVQRVYWEKEDEESMKFLNIKACNISLRCQDEGKSPGGCVQGYPIPKGAEIIPEAMKYLRGKKSRYGGIKDKNGELKLPLSVRVWVRMANLSGWVNGTPPYWSARINGSTGINGTRWYGIGTLHHLGCNISSNPERGICNFTGELWIGGDKFPYYYTPSWNCSQNWTGHPVWHVFRYLDMTEHMTSRCIQRPKRHNITVGNGTITGNCSVTNWDGCNCTRSGNHLYNSTSGGLLVIICRQNSTITGIMGTNTNWTTMWNIYQNCSRCNNSSLDRTGSGTLGTVNNLKCSLPHRNESNKWTCKSQRDSYIAGRDFWGKVKAKYSCESNLGGLDSMMHQQMLLQRYQVIRVRAYTYGVVEMPQSYMEAQGENKRSRRNLQRKKRGIGLVIVLAIMAIIAAAGAGLGVANAVQQSYTRTAVQSLANATAAQQEVLEASYAMVQHIAKGIRILEARVARVEALVDRMMVYQELDCWHYQHYCVTSTRSEVANYVNWTRFKDNCTWQQWEEEIEQHEGNLSLLLREAALQVHIAQRDARRIPDAWKAIQEAFNWSSWFSWLKYIPWIIMGIVGLMCFRILMCVISMCLQAYKQVKQIRYTQVTVVIEAPVELEEKQKRNGDGTNGCASLERERRTSHRSFIQIWRATWWAWKTSPWRHNWRTMPYITLLPILVIWQWMEENGWNGENQHKKKKERVDCQDREQMPTLENDYVEL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: AMBN_HUMAN
Sequence: MSASKIPLFKMKDLILILCLLEMSFAVPFFPQQSGTPGMASLSLETMRQLGSLQRLNTLSQYSRYGFGKSFNSLWMHGLLPPHSSLPWMRPREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATTNQATALKEALQPPIHLGHLPLQEGELPLVQQQVAPSDKPPKPELPGVDFADPQGPSLPGMDFPDPQGPSLPGLDFADPQGSTIFQIARLISHGPMPQNKQSPLYPGMLYVPFGANQLNAPARLGIMSSEEVAGGREDPMAYGAMFPGFGGMRPGFEGMPHNPAMGGDFTLEFDSPVAATKGPENEEGGAQGSPMPEANPDNLENPAFLTELEPAPHAGLLALPKDDIPGLPRSPSGKMKGLPSVTPAAADPLMTPELADVYRTYDADMTTSVDFQEEATMDTTMAPNSLQTSMPGNKAQEPEMMHDAWHFQEP
What is the function of this protein?
Involved in the mineralization and structural organization of enamel.
What are the official names of this protein?
Ameloblastin.
What is the protein family that this protein belongs to?
Belongs to the ameloblastin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PRT1A_ONCMY
Sequence: MPRRRRASRRVRRRRRPRVSRRRRRGGRRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-1A, Protamine PRTP43/PPC 2E.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RS7_LIMRD
Sequence: MPRKGHVQKREILPDPMYNSKLVTSLIDHLMIDGKRGTATKILYAAFDEIKNETGNDPVEVFQQAMENVMPVLEVKARRVGGSNYQVPIEVRPDRRTTLGLRWIVQYARLRGEHTMVERLAREIIDASNNTGASVKKREDTHRMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y103_SYNY3
Sequence: MRIDLSLLLSDQNLDAGAPTSQRQLRIAVAAKADDHDRRLPLNLCLVLDHSGSMDGQPLETVKSAALGLIDRLEEDDRLSVIAFDHRAKIVIENQQVRNGAAIAKAIERLKAEGGTAIDEGLKLGIQEAAKGKEDRVSHIFLLTDGENEHGDNDRCLKLGTVASDYKLTVHTLGFGDHWNQDVLEAIAASAQGSLSYIENPSEALHTFRQLFQRMSNVGLTNAHLLLELAPQAHLAIVKPVAQVSPETMDLTVQNQGAIEEVRLGDLMTDQERVLLLNLYLDQLLPGQHVIGQVQIRYDDPASGQTNLLSDPLPLTIQVQTQYQPSTDVQVQESILTLAKYRQTQIAETKLKAGDRQGAATMLQTAAKTALQMGDKNGATILQTNATRLQSGEDLSEGDRKKTRMVSKTTLQPPSAPSEH
What are the official names of this protein?
Uncharacterized protein sll0103.
Protein: RS20_MESFL
Sequence: MPNIKSQKKRVLTNEKSRASNKAIKSEIRTAIKKALAAKKDEATDATDLINHAVSLVDKGVKKGILKPNKAAREKSRLMQA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DNAI2_HUMAN
Sequence: MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEALFCLRVQDNGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEARHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFAELKKKEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA
What is the function of this protein?
Part of the dynein complex of respiratory cilia.
What are the official names of this protein?
Dynein axonemal intermediate chain 2, Axonemal dynein intermediate chain 2.
What is the protein family that this protein belongs to?
Belongs to the dynein intermediate chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle. Note=Located in the proximal region of respiratory cilia.
Protein: RR4_HORMA
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFNSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQNYIASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL11_LACDB
Sequence: MAKKVINVVKLQIPAGAATPAPPVGPALGQAGINIVGFTKDFNARTADQKGMIIPVVITVYEDRSFDFVTKTPPAPVLLKQAAGIQKASGEPNKNKVGSVTTAQVKEIAETKMKDLNAASIEAAMRMVEGTARSMGIEVKD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ITPK1_ORYSI
Sequence: MRVHEEASEDKEREVEEAPDLMPLSPPPTAAATAAVVAVAGQRLVVGYALTKKKVKSFLQPKLLSLARKKSIHFVSIDETRPLSEQGPFDIILHKLTDKEWQQVLEDYREEHPEVTVLDPPNAIQHLHNRQSMLQEVADLNLSNAYGEVCTPRQLVIMKDPLSIPSAVAKAGLTLPLVAKPLVVDGTSKSHELSLAYVETSLSMLDPPLVLQEFVNHGGILFKVYVVGETIRVVRRFSLPDVNIYDLENNDGIFRFPRVSCATNTAEDAEVDPSIAELPPKPLLEKLGRELRRRLGLRLFNFDMIREHGRKDRYYVIDINYFPGYGKMPGYEHIFIDFLLSLVQNKYKRRLSGS
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds.  Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase 1, Inositol 1,3,4-trisphosphate 5/6-kinase 1, Inositol-triphosphate 5/6-kinase 1, Ins(1,3,4)P(3) 5/6-kinase 1, OsITP5/6K-1, OsITPK1.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: RL6_PSEAE
Sequence: MSRVAKNPVKLPAGVEIKLAGQQLSIKGAKGALELKVHPSVEVIQDSGELRFAARNGDQQTRAMAGTTRALVNNMVVGVSQGFERKLQLVGVGYKAQAKGQVLSLSLGFSHPVDYELPAGIVAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RN224_MOUSE
Sequence: MLQPEGLYALEEGTALTASRNDCIICYSAYDLSVHLPRRLYCGHTFCQACMQRLDMPAHEQHWIPCPQCRQSTPVPRGGVTMLDLDLAAFLAVKAEREPSKIEPRSSVPLKISTTITQQPAGLYPTLGPQPHFPQPGCCCWGWGRLCWYPPGNPEV
What are the official names of this protein?
RING finger protein 224.
Protein: GBB1_MOUSE
Sequence: MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transducin beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
Protein: SPXH_HALH5
Sequence: MAHHENQTNCNDERGICSLDSDADDQKQKKRKPLEIYTFIDPLCPECWAFEPILKKLQVEYGQYFRIRFIVAGKLEAWNLCRGKYKGAQSREDLAHVWRKITETFGMPCDGDVWLEDPITSSYTPSLAIKAAELQGPQAGVRFLRKLREHLFLNKQNVTKEDILISCAQRAGLDVKEFKQDLHSKGAAKALRCDMQTTKEMDVDLVPTFVFFNDNVDEEGIKVTGHYPYHIYVQILEDMLGFKPERQPPMSLEHFLKKYEFVASIEVAVVFDLEIDEAEKQLKKLVLKQKLELVPMKYGNFWRYLE
What is the function of this protein?
Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions.  Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.
What are the official names of this protein?
ClpXP adapter protein SpxH.
What is the protein family that this protein belongs to?
Belongs to the SpxH family.
Protein: EFTS_BRUC2
Sequence: MSISASLVKELRDLTGAGMMDCKAALAATEGKIEAAVDWLRAKGIAKADKKAGRTAAEGLVGVAASGNKAVVVEVNSETDFVARNDAFQELVRKIAQAALSTDGSSEAVANANVDGKTVTEAAKDAVATIGENISFRRSAALSVPQGVVATYIHNGVADGLGKLGVLVAIETAGDAEAAQAFGRQVAMHVAAVNPLALTSADVNPEAAEREKAIFIDQARQSGKPDNIIEKMVEGRMRKFYEEVVLLSQAFVINPDLTVEAALKDAEKAIGAPAKITGFARIALGEGIEKEESDFAAEVAAAAKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD39_HUMAN
Sequence: MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK
What is the function of this protein?
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972).  Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity).  Not required for outer dynein arm complexes assembly (PubMed:21131972).
What are the official names of this protein?
Coiled-coil domain-containing protein 39.
What is the protein family that this protein belongs to?
Belongs to the CCDC39 family.
Protein: SINL2_ARATH
Sequence: MSGEASTSRRKRQRVPSSVESVENGGGDAVARSGTLFELDLLDCPICCHALTSPIFQCDNGHIACSSCCTKLRNKCPSCALPIGNFRSRIMERVVEAVMVTCPNVKHGCTEKFSYGKELIHEKDCRFALCYCPAPNCNYSGVYKDLYSHFYVNHYDTWNQIGCGNFAGAWLRISEKILVLQYGQGPLIAVQCFKETQGMYVTVNCIAPCAPGVGELSFELSYKMPMGGNSTMMFKSEEMNRIQKVSFQTPEKDFMLVPYYFLGDFSTLKMEICIRKLKKDEEEADEDEESEEEEDDDDDDDDDDEEEDADEEE
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  It probably triggers the ubiquitin-mediated degradation of different substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase SINA-like 2, RING-type E3 ubiquitin transferase SINA-like 2, Seven in absentia-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
Protein: DUT_XANAC
Sequence: MSPPTQSLQVKLLDPRFGDLWPLPAYATESSAGMDLRAALEAPMTLQPGDAALIPSGIAIHLADPQLCAVILPRSGLGHRHGIVLGNGTGLIDADYQGPLLISTWNRGREAFTIEPGDRIAQLVILPIVRMGLQVVDTFVDSARGAGGFGHTGVR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: UREG_STAXY
Sequence: MTDTIKIGVGGPVGAGKHELIEKIVKRLAKDMSIGVITNDIYTKEDEKILVNSGVLPEDRIIGVETGGCPHTAIREDASMNFAAIDELKERNDDIELIFIESGGDNLAATFSPELVDFSIYIIDVAQGEKIPRKGGQGMIKSDFFVINKTDLAPYVGASLERMAEDTKVFRGNRPFTFTNLKTDEGLDEVIEWIEQYVFLKGLA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_CHRVO
Sequence: MTDQYVLALDQGTTSSRAILFNRSGDIVSLAQKEFRQIYPQPGWVEHDPQEIWGGQVGVAAEAVAKAGIDGRSIAAIGITNQRETTIVWDRETGQPVYNAIVWQDRRTAEFCDELKARGLGELIRSKTGLLVDAYFSGSKIKWILDNVPGARDRAREGKLAFGTVDSWLIWNFTHGKVHVTDVSNASRTMLYNIHTLQWDAELLDIMGIPASMLPEVKSSSEVYGHTHAAHLGVEIPIAGVAGDQQAALFGQQCTTPGMVKNTYGTGCFMMLNTGDKPIESSNNLLTTIAWKVDGKVQYALEGSIFIGGAVVKWLRDGLGIIRHSADVGPLAQEVKNSDGVYLVPAFAGLGAPHWNASARGTIVGATLGTKAAHIARAALDSIAYQTRDVLKAMEADAGMSIAELRVDGGATVNELLMQFQSDILAVDVVRPKITETTALGAAYLAGLAVGYWKSVDDIQGQWQLDRRFQPAMAADEVLANVKGWQRAVNAAKVWADDQA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PURA_BLOPB
Sequence: MARSIVVLGAQWGDEGKGKIVDWLTSRAQYVVRYQGGHNAGHTIVVDQQKITLHLIPSGILHNHVTAVIANGVVLSPFSLIKEMKMLLKLGVSTCKRIFISASCPLLLPYHVAMDLARENHHISKAIGTTGCGIGPSYEDKVARRALRVSDLYNLKYFKNKLKDVVDYYNFQLVYYYKTKPINYQIVLEEVMSISDILIDMVVDVPELLDDAAKRGDSVIFEGAQGSLLDIDHGTYPYVTSSHTIAGSVSVGAGVGLNYIDYVLGIVKAYSTRVGFGPFPTELSNDTGNWLCMNGNEFGSTTGRRRRTGWFDAVSVRYSVKINSFFSCCLTKIDVLDGLKELKICIAYRKKNGKVIHNFPCSLEELENCVPIYEILPGWMISTVGITEFHQLPKESQLYVKRIEELIGVPIHIVSTGSDRSAIIILRNPFDS
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YICJ_ECOLI
Sequence: MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN
What are the official names of this protein?
Inner membrane symporter YicJ.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TGT_SALAR
Sequence: MKFELDTTDGRARRGRLVFERGVVETPAFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKCSMEMSLRWAKRSRDRFDGLGNKNALFGIIQGSVYEDLRDISVKGLVEIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKSDTSPLDAECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTEFYQRQGRPVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.